# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- VCBS PF13517.6 KOO20783.1 - 8e-118 385.1 142.9 6.2e-13 49.1 4.9 12.4 1 1 11 12 12 12 12 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO20783.1 - 4.5e-58 192.9 128.4 4.3e-05 23.5 1.7 13.6 13 0 0 13 13 13 13 FG-GAP repeat Ephrin_rec_like PF07699.13 KOO20783.1 - 3.4e-19 68.3 77.2 6.8e-08 32.2 1.4 9.7 3 1 5 9 9 9 7 Putative ephrin-receptor like Dockerin_1 PF00404.18 KOO20783.1 - 3.6e-09 36.7 35.7 17 5.7 0.0 12.8 13 0 0 13 13 13 2 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO20783.1 - 0.0015 17.9 62.7 3.2 7.1 0.3 13.0 2 2 9 13 13 13 6 Insecticide toxin TcdB middle/N-terminal region RIC3 PF15361.6 KOO20783.1 - 0.081 13.3 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Glyco_transf_56 PF07429.11 KOO20783.1 - 1.4 8.0 5.8 38 3.2 0.0 5.4 11 0 0 11 11 11 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 PDZ_6 PF17820.1 KOO20785.1 - 4.1e-24 84.2 1.5 5.2e-11 42.2 0.1 3.4 3 0 0 3 3 3 2 PDZ domain Ank_2 PF12796.7 KOO20785.1 - 8.1e-24 84.0 0.1 4.9e-12 46.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PDZ PF00595.24 KOO20785.1 - 5.5e-15 55.5 0.0 1.3e-06 28.7 0.0 2.6 2 0 0 2 2 2 2 PDZ domain Ank_5 PF13857.6 KOO20785.1 - 6.9e-14 51.7 0.5 3.9e-08 33.4 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO20785.1 - 5.3e-13 49.2 0.1 3.4e-08 33.9 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) PDZ_2 PF13180.6 KOO20785.1 - 6.6e-13 48.8 0.2 2.5e-05 24.5 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Ank PF00023.30 KOO20785.1 - 3.5e-10 39.8 0.1 0.0032 17.8 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO20785.1 - 1.1e-09 37.7 0.1 0.0057 17.1 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Tricorn_PDZ PF14685.6 KOO20785.1 - 2.1e-08 34.0 0.1 0.0092 15.9 0.0 2.8 2 0 0 2 2 2 2 Tricorn protease PDZ domain EF-hand_1 PF00036.32 KOO20786.1 - 6.6e-19 66.0 0.4 2e-05 23.8 0.0 4.7 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO20786.1 - 1.4e-17 63.9 0.1 1.1e-09 38.6 0.0 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO20786.1 - 1.6e-17 63.1 1.0 9.7e-06 25.3 0.0 5.0 2 1 3 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO20786.1 - 2.8e-16 58.0 0.7 0.00028 20.6 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KOO20786.1 - 7.1e-10 37.9 1.0 0.0079 15.6 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 KOO20786.1 - 1.1e-05 25.7 0.0 0.015 15.6 0.0 3.4 2 1 1 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO20786.1 - 0.0053 17.1 0.5 1.8 8.9 0.0 3.1 2 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Sigma54_CBD PF04963.13 KOO20786.1 - 0.0082 16.0 2.3 0.097 12.5 0.0 2.9 2 1 0 3 3 3 1 Sigma-54 factor, core binding domain EF-hand_10 PF14788.6 KOO20786.1 - 0.017 15.0 0.3 9.8 6.1 0.0 3.5 2 1 1 3 3 3 0 EF hand Fib_alpha PF08702.10 KOO20786.1 - 2.5 8.3 5.5 0.44 10.7 0.3 2.4 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Syntaxin_2 PF14523.6 KOO20786.1 - 4.4 7.7 7.8 1.6 9.1 0.1 3.7 3 1 1 4 4 4 0 Syntaxin-like protein SCP1201-deam PF14428.6 KOO20787.1 - 0.0017 18.2 54.1 2.1 8.2 0.4 11.6 1 1 10 11 11 11 10 SCP1.201-like deaminase PhyH PF05721.13 KOO20790.1 - 5.3e-08 33.4 0.2 4e-05 24.0 0.2 2.3 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) SepRS_C PF18006.1 KOO20790.1 - 2.6e-07 30.6 0.0 6.2 7.0 0.0 6.1 7 0 0 7 7 7 3 O-phosphoseryl-tRNA synthetase C-terminal domain Filamin PF00630.19 KOO20791.1 - 2.9e-30 105.1 0.1 1.9e-06 28.6 0.0 5.3 4 1 1 5 5 5 5 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO20791.1 - 2.1e-09 37.5 10.5 0.00035 20.8 0.0 4.9 5 0 0 5 5 5 3 Invasin, domain 3 Big_1 PF02369.16 KOO20791.1 - 0.0087 16.1 0.4 9.1 6.4 0.0 5.3 6 1 0 6 6 6 1 Bacterial Ig-like domain (group 1) Josephin PF02099.17 KOO20793.1 - 1.2e-07 31.9 0.6 1.5e-05 25.2 1.1 2.8 2 1 0 2 2 2 2 Josephin TPR_19 PF14559.6 KOO20794.1 - 1.6e-07 31.7 7.4 0.0046 17.5 0.3 4.4 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO20794.1 - 4.2e-07 30.2 5.3 0.075 13.9 0.7 5.3 3 1 3 6 6 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO20794.1 - 5.7e-07 29.2 9.5 0.062 13.4 0.5 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO20794.1 - 7.3e-07 29.7 3.0 0.0011 19.6 0.1 4.1 2 1 2 4 4 4 2 Tetratricopeptide repeat YfiO PF13525.6 KOO20794.1 - 0.0022 17.7 2.8 0.024 14.4 0.6 2.1 1 1 1 2 2 2 1 Outer membrane lipoprotein TPR_8 PF13181.6 KOO20794.1 - 0.0038 17.3 6.2 3.7 8.0 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO20794.1 - 0.013 15.7 3.7 0.048 13.9 2.1 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 ST7 PF04184.12 KOO20794.1 - 0.017 13.6 0.3 0.022 13.2 0.3 1.1 1 0 0 1 1 1 0 ST7 protein Fis1_TPR_C PF14853.6 KOO20794.1 - 0.042 13.9 6.4 0.086 12.9 0.2 3.5 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 KOO20794.1 - 0.052 13.7 4.1 11 6.3 0.8 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO20794.1 - 0.07 13.0 7.5 6.9 6.7 0.5 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat BRE1 PF08647.11 KOO20794.1 - 0.7 10.0 3.8 7.6 6.7 4.0 2.2 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase TPR_6 PF13174.6 KOO20794.1 - 1.3 9.8 3.6 61 4.6 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat HEAT_EZ PF13513.6 KOO20795.1 - 7.3 7.2 18.1 18 6.0 1.0 5.6 5 1 1 6 6 6 0 HEAT-like repeat Seipin PF06775.14 KOO20796.1 - 1.4e-29 103.6 0.0 2.2e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) CAP_N PF01213.19 KOO20796.1 - 5.9 6.3 4.9 0.85 9.0 0.5 1.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal FA_desaturase PF00487.24 KOO20797.1 - 5.2e-15 56.0 22.7 5.2e-15 56.0 22.7 2.2 1 1 1 2 2 2 2 Fatty acid desaturase Ank_5 PF13857.6 KOO20798.1 - 7.9e-18 64.3 1.5 2e-08 34.4 0.1 2.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO20798.1 - 1.5e-16 60.8 0.0 8.5e-07 29.5 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO20798.1 - 1.7e-12 47.6 2.5 6e-05 23.5 0.0 4.7 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO20798.1 - 9.6e-12 44.0 0.2 0.016 15.7 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO20798.1 - 1.4e-09 37.9 1.4 0.0008 19.8 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat tRNA-synt_1 PF00133.22 KOO20799.1 - 3.7e-63 213.7 0.3 1.9e-38 132.1 0.0 4.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 KOO20799.1 - 1.2e-57 194.4 0.0 1.9e-57 193.8 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 KOO20799.1 - 1.2e-23 83.5 0.1 1.3e-15 57.1 0.0 3.3 4 1 0 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KOO20799.1 - 5.1e-17 62.2 0.1 1.5e-16 60.8 0.1 1.7 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 KOO20799.1 - 2.9e-05 23.6 0.0 0.0032 16.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 KOO20799.1 - 0.14 11.1 0.0 0.3 10.0 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (K) tRNA-synt_1d PF00750.19 KOO20799.1 - 0.17 10.8 0.0 0.45 9.4 0.1 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (R) DUF1242 PF06842.12 KOO20800.1 - 1.4e-12 47.2 0.1 2.2e-12 46.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Glucosamine_iso PF01182.20 KOO20802.1 - 2.7e-20 73.2 0.0 4.1e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase IFT57 PF10498.9 KOO20803.1 - 7.2e-99 331.2 0.0 1e-98 330.7 0.0 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DUF948 PF06103.11 KOO20803.1 - 0.00047 20.3 1.1 0.0022 18.2 1.1 2.1 2 0 0 2 2 1 1 Bacterial protein of unknown function (DUF948) Transcrip_act PF04949.13 KOO20803.1 - 0.00085 19.2 2.2 0.00085 19.2 2.2 2.6 3 1 1 4 4 4 1 Transcriptional activator NPV_P10 PF05531.12 KOO20803.1 - 0.012 16.1 3.6 0.022 15.2 2.5 2.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 KOO20803.1 - 0.021 15.3 2.2 0.021 15.3 2.2 1.9 2 0 0 2 2 1 0 Protein of unknown function DUF16 THP2 PF09432.10 KOO20803.1 - 0.023 14.7 0.8 0.098 12.7 0.8 2.1 1 0 0 1 1 1 0 Tho complex subunit THP2 CENP-H PF05837.12 KOO20803.1 - 0.023 15.1 5.4 0.023 15.1 5.4 3.0 2 1 2 4 4 4 0 Centromere protein H (CENP-H) Snapin_Pallidin PF14712.6 KOO20803.1 - 0.03 14.7 5.9 0.033 14.6 2.7 2.6 1 1 0 2 2 2 0 Snapin/Pallidin DUF3037 PF11236.8 KOO20803.1 - 0.044 14.2 0.2 0.21 12.1 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3037) DUF1043 PF06295.12 KOO20803.1 - 0.06 13.3 2.8 0.86 9.6 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) SpecificRecomb PF10136.9 KOO20803.1 - 0.11 10.8 2.3 0.15 10.3 2.3 1.2 1 0 0 1 1 1 0 Site-specific recombinase Phage_GPO PF05929.11 KOO20803.1 - 0.12 11.9 7.6 0.087 12.4 5.6 1.7 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Spc7 PF08317.11 KOO20803.1 - 0.14 11.0 8.7 0.24 10.3 8.7 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Sec34 PF04136.15 KOO20803.1 - 0.14 12.1 3.6 0.51 10.2 3.8 1.8 1 1 0 1 1 1 0 Sec34-like family Exonuc_VII_L PF02601.15 KOO20803.1 - 0.3 10.6 5.3 0.47 10.0 5.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DASH_Dam1 PF08653.10 KOO20803.1 - 0.31 10.9 2.0 1.4 8.8 0.3 3.0 3 1 0 3 3 3 0 DASH complex subunit Dam1 Fez1 PF06818.15 KOO20803.1 - 0.35 11.3 8.0 0.47 10.9 6.8 1.7 1 1 0 1 1 1 0 Fez1 Syntaxin_2 PF14523.6 KOO20803.1 - 0.49 10.8 11.1 0.13 12.6 3.2 3.2 2 1 0 3 3 3 0 Syntaxin-like protein UPF0242 PF06785.11 KOO20803.1 - 0.73 9.9 7.4 0.75 9.9 5.9 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YlqD PF11068.8 KOO20803.1 - 0.95 9.8 7.3 0.13 12.7 2.6 2.0 2 0 0 2 2 1 0 YlqD protein FliD_N PF02465.18 KOO20803.1 - 1.4 9.7 6.1 6.4 7.5 6.1 2.2 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus KxDL PF10241.9 KOO20803.1 - 1.5 9.1 7.8 0.45 10.8 2.8 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein DUF1664 PF07889.12 KOO20803.1 - 4 7.5 8.0 1.1 9.3 3.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HIP1_clath_bdg PF16515.5 KOO20803.1 - 8.6 7.0 15.7 7.4 7.3 7.3 3.1 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Activator-TraM PF11657.8 KOO20804.1 - 0.014 15.2 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Transcriptional activator TraM LSDAT_euk PF18139.1 KOO20805.1 - 3.8e-23 82.2 0.0 5.5e-17 62.0 0.0 2.3 2 0 0 2 2 2 2 SLOG in TRPM Ion_trans PF00520.31 KOO20805.1 - 2.2e-08 33.6 15.7 0.0014 17.9 13.3 2.2 2 0 0 2 2 2 2 Ion transport protein LSDAT_prok PF18171.1 KOO20805.1 - 1.2e-06 27.9 0.0 0.0073 15.6 0.1 2.5 2 0 0 2 2 2 2 SLOG in TRPM, prokaryote WW PF00397.26 KOO20805.1 - 0.00013 21.9 2.0 0.00046 20.2 2.0 2.0 1 0 0 1 1 1 1 WW domain Epimerase PF01370.21 KOO20806.1 - 1e-22 80.8 0.0 1.4e-22 80.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO20806.1 - 8.1e-14 51.3 0.0 1.2e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KOO20806.1 - 2.9e-13 50.1 0.6 4e-13 49.6 0.6 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 KOO20806.1 - 1.2e-10 41.4 0.0 1.7e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 KOO20806.1 - 3.5e-07 30.0 1.2 5.5e-06 26.1 0.6 2.1 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 KOO20806.1 - 1.5e-06 27.6 0.8 0.00018 20.8 0.0 2.4 2 1 0 2 2 2 2 Male sterility protein KR PF08659.10 KOO20806.1 - 0.031 14.2 4.0 0.041 13.8 0.1 2.5 3 0 0 3 3 3 0 KR domain Polysacc_synt_2 PF02719.15 KOO20806.1 - 0.041 13.0 2.6 0.49 9.5 2.6 2.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Ank_4 PF13637.6 KOO20807.1 - 8.4e-28 96.4 0.7 1.6e-10 41.3 0.0 4.2 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO20807.1 - 7.1e-27 93.8 0.3 4.1e-13 49.7 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO20807.1 - 3.3e-24 82.3 1.9 4.6e-05 23.5 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 KOO20807.1 - 7.1e-21 74.0 1.8 1e-08 35.3 0.1 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KOO20807.1 - 2.1e-19 69.0 0.6 0.00071 19.9 0.1 4.6 3 1 1 4 4 4 4 Ankyrin repeat ADAM_CR PF08516.12 KOO20807.1 - 0.0098 16.3 0.8 0.02 15.3 0.8 1.5 1 0 0 1 1 1 1 ADAM cysteine-rich Phospholip_A2_2 PF05826.12 KOO20807.1 - 0.095 12.9 0.8 0.18 12.0 0.2 1.8 1 1 0 1 1 1 0 Phospholipase A2 DUF695 PF05117.12 KOO20807.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF695) PDZ PF00595.24 KOO20808.1 - 1.5e-07 31.6 0.0 2.4e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO20808.1 - 3.7e-06 27.2 0.1 6.7e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO20808.1 - 6e-05 22.8 0.1 9.3e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 PDZ domain DUF4245 PF14030.6 KOO20808.1 - 0.011 15.7 0.1 0.031 14.3 0.0 1.5 1 1 0 2 2 2 0 Protein of unknown function (DUF4245) AI-2E_transport PF01594.16 KOO20809.1 - 2.7e-36 125.4 34.1 1e-24 87.3 18.9 3.2 3 0 0 3 3 3 3 AI-2E family transporter Sugar_tr PF00083.24 KOO20810.1 - 1.6e-70 238.3 4.7 2.4e-53 181.6 0.6 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOO20810.1 - 1.8e-24 86.4 26.0 3e-23 82.3 25.8 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 KOO20810.1 - 2e-09 36.5 3.7 5.2e-08 31.8 1.5 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 KOO20810.1 - 0.0016 17.4 0.5 0.089 11.6 2.8 2.2 1 1 2 3 3 3 1 MFS_1 like family MFS_2 PF13347.6 KOO20810.1 - 0.35 9.4 15.6 0.5 8.9 3.8 2.5 2 1 1 3 3 3 0 MFS/sugar transport protein EamA PF00892.20 KOO20812.1 - 7.5e-13 48.8 18.5 9.9e-07 29.0 9.7 2.1 2 0 0 2 2 2 2 EamA-like transporter family ABC2_membrane_5 PF13346.6 KOO20812.1 - 0.22 11.1 5.0 0.14 11.7 1.4 2.2 1 1 1 2 2 2 0 ABC-2 family transporter protein Baculo_p74 PF04583.12 KOO20812.1 - 0.23 10.9 1.1 0.36 10.3 1.1 1.2 1 0 0 1 1 1 0 Baculoviridae p74 conserved region Form-deh_trans PF09163.11 KOO20812.1 - 0.27 11.0 2.6 0.25 11.2 0.4 2.1 2 0 0 2 2 2 0 Formate dehydrogenase N, transmembrane Ank_4 PF13637.6 KOO20813.1 - 8.6e-28 96.4 2.0 1.4e-10 41.5 0.0 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO20813.1 - 1.4e-26 92.9 0.7 3.6e-13 49.9 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO20813.1 - 2.2e-24 82.8 1.9 4.2e-05 23.6 0.0 5.3 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 KOO20813.1 - 5e-21 74.5 1.6 1.9e-08 34.4 0.1 5.4 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 KOO20813.1 - 1.6e-19 69.4 0.8 0.00069 20.0 0.2 4.6 3 1 1 4 4 4 4 Ankyrin repeat ADAM_CR PF08516.12 KOO20813.1 - 0.019 15.3 1.9 0.039 14.4 1.9 1.6 1 1 0 1 1 1 0 ADAM cysteine-rich Phospholip_A2_2 PF05826.12 KOO20813.1 - 0.056 13.7 1.0 0.1 12.9 0.2 1.8 1 1 0 1 1 1 0 Phospholipase A2 DUF4140 PF13600.6 KOO20813.1 - 0.35 11.3 6.2 6.6 7.2 4.9 2.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF3391 PF11871.8 KOO20813.1 - 6.5 7.3 9.6 17 6.0 9.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DHDPS PF00701.22 KOO20814.1 - 2.6e-86 289.0 0.0 3.5e-86 288.5 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Saccharop_dh_N PF04455.12 KOO20814.1 - 2.4e-11 43.9 0.2 6.3e-11 42.6 0.2 1.7 1 1 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region Filamin PF00630.19 KOO20815.1 - 4.9e-18 65.9 0.0 1.6e-11 44.9 0.0 3.9 3 1 0 3 3 3 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO20815.1 - 1.3e-06 28.6 0.1 1.3e-06 28.6 0.1 3.9 5 1 0 5 5 5 1 Invasin, domain 3 Neurexophilin PF06312.12 KOO20815.1 - 0.001 18.6 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 Neurexophilin Big_1 PF02369.16 KOO20815.1 - 0.0012 18.9 4.0 0.32 11.0 0.0 3.8 4 0 0 4 4 4 2 Bacterial Ig-like domain (group 1) DUF5060 PF16586.5 KOO20815.1 - 0.11 12.8 0.0 3.9 7.9 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) BclA_C PF18573.1 KOO20815.1 - 0.12 12.2 0.0 1.8 8.5 0.0 2.6 3 0 0 3 3 3 0 BclA C-terminal domain YtkA PF13115.6 KOO20815.1 - 0.42 11.2 2.7 4.8 7.9 0.0 3.8 2 2 2 4 4 4 0 YtkA-like TAF4 PF05236.14 KOO20815.1 - 1.4 8.6 12.9 0.091 12.5 7.1 1.8 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family K-cyclin_vir_C PF09080.10 KOO20817.1 - 1.1 9.7 5.9 0.17 12.3 1.6 2.0 2 0 0 2 2 2 0 K cyclin, C terminal Methyltransf_PK PF05891.12 KOO20818.1 - 2.3e-37 128.6 0.0 3.6e-37 128.0 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Pepdidase_M14_N PF18027.1 KOO20818.1 - 5.5e-18 65.3 0.7 1.1e-17 64.4 0.7 1.5 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 KOO20818.1 - 3.6e-13 50.0 0.0 6.3e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase Methyltransf_11 PF08241.12 KOO20818.1 - 2e-08 34.8 0.0 1.1e-07 32.4 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO20818.1 - 4e-08 33.8 0.1 8.9e-07 29.5 0.1 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO20818.1 - 4.5e-06 26.6 0.0 8.1e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO20818.1 - 1.5e-05 25.6 0.0 6e-05 23.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 KOO20818.1 - 0.043 13.1 0.0 0.098 11.9 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_24 PF13578.6 KOO20818.1 - 0.083 13.9 0.0 0.23 12.5 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Cytotoxic PF09000.10 KOO20818.1 - 0.89 9.9 3.1 2.5 8.5 3.1 1.7 1 0 0 1 1 1 0 Cytotoxic DivIC PF04977.15 KOO20819.1 - 0.006 16.3 0.0 0.0096 15.7 0.0 1.3 1 0 0 1 1 1 1 Septum formation initiator ADIP PF11559.8 KOO20819.1 - 0.0078 16.3 0.3 0.0093 16.1 0.3 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding OTCace_N PF02729.21 KOO20819.1 - 0.014 15.4 0.1 0.017 15.1 0.1 1.2 1 1 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain FlaC_arch PF05377.11 KOO20819.1 - 0.017 15.5 0.0 0.027 14.9 0.0 1.2 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) FmiP_Thoc5 PF09766.9 KOO20819.1 - 0.078 12.2 0.8 0.094 12.0 0.8 1.0 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 UDPGP PF01704.18 KOO20820.1 - 3.8e-41 141.1 0.0 5.4e-41 140.6 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase WD40 PF00400.32 KOO20820.1 - 5.2e-28 96.7 4.7 7.2e-09 36.1 0.2 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO20820.1 - 2e-07 30.3 0.5 0.12 11.3 0.1 3.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO20820.1 - 5.2e-06 26.3 0.1 3.8 7.6 0.0 3.6 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 KOO20820.1 - 8e-06 26.1 0.2 0.64 10.4 0.0 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain NTP_transf_3 PF12804.7 KOO20820.1 - 0.00024 21.5 0.0 0.00094 19.6 0.0 2.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain Frtz PF11768.8 KOO20820.1 - 0.013 13.9 0.0 1.7 6.9 0.0 2.3 2 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO20820.1 - 0.044 13.1 0.4 3.8 6.7 0.1 2.4 1 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DEAD PF00270.29 KOO20821.1 - 3e-13 49.9 0.0 5.8e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO20821.1 - 7e-10 39.2 0.0 1.6e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 KOO20821.1 - 4.5e-09 36.9 4.5 4.5e-09 36.9 4.5 2.0 2 0 0 2 2 2 1 RecQ zinc-binding Spc7 PF08317.11 KOO20823.1 - 0.0017 17.3 13.9 0.0037 16.2 13.9 1.6 1 0 0 1 1 1 1 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 KOO20823.1 - 0.023 14.8 8.2 0.023 14.8 8.2 3.9 3 1 2 5 5 5 0 TPR/MLP1/MLP2-like protein WEMBL PF05701.11 KOO20823.1 - 0.047 12.4 25.6 0.46 9.1 25.6 2.2 1 1 0 1 1 1 0 Weak chloroplast movement under blue light LCD1 PF09798.9 KOO20823.1 - 0.12 10.9 0.7 0.15 10.5 0.7 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Phage_HK97_TLTM PF06120.11 KOO20823.1 - 0.14 11.3 3.6 4.5 6.4 2.3 2.2 2 0 0 2 2 2 0 Tail length tape measure protein SNARE PF05739.19 KOO20823.1 - 0.17 11.9 13.7 1.9 8.6 0.8 3.5 2 1 2 4 4 4 0 SNARE domain CENP-F_leu_zip PF10473.9 KOO20823.1 - 0.23 11.5 20.1 0.032 14.2 11.3 2.6 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4201 PF13870.6 KOO20823.1 - 0.64 9.7 14.4 0.024 14.4 2.9 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) EzrA PF06160.12 KOO20823.1 - 0.96 7.5 9.3 1.5 6.9 9.3 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA BAR_2 PF10455.9 KOO20823.1 - 1.3 8.1 10.8 28 3.7 10.8 2.8 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Fez1 PF06818.15 KOO20823.1 - 1.5 9.2 21.1 0.77 10.2 12.3 2.3 1 1 1 2 2 2 0 Fez1 Golgin_A5 PF09787.9 KOO20823.1 - 3.2 7.1 18.5 1.8 8.0 13.5 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 YscO-like PF16789.5 KOO20823.1 - 3.5 7.6 20.2 4.2 7.4 13.8 3.5 2 1 1 3 3 3 0 YscO-like protein CENP-H PF05837.12 KOO20823.1 - 4 7.9 26.6 6.4 7.2 9.3 3.2 2 1 1 3 3 3 0 Centromere protein H (CENP-H) DUF2564 PF10819.8 KOO20823.1 - 4.2 7.8 21.8 0.88 10.0 3.6 3.9 3 1 0 3 3 2 0 Protein of unknown function (DUF2564) COG2 PF06148.11 KOO20823.1 - 4.2 7.4 9.4 14 5.8 2.4 3.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 HIP1_clath_bdg PF16515.5 KOO20823.1 - 4.5 7.9 24.0 0.18 12.5 7.9 3.9 2 2 2 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DLP_helical PF18709.1 KOO20823.1 - 7 5.7 12.1 0.96 8.6 3.2 2.3 1 1 2 3 3 3 0 Dynamin-like helical domain DUF1640 PF07798.11 KOO20823.1 - 7.4 6.6 14.4 27 4.7 14.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) BRE1 PF08647.11 KOO20823.1 - 9.3 6.4 12.3 0.79 9.8 1.6 3.0 4 0 0 4 4 3 0 BRE1 E3 ubiquitin ligase DnaJ PF00226.31 KOO20824.1 - 2.9e-23 81.8 0.2 5.4e-23 80.9 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.6 KOO20824.1 - 1.3e-20 73.7 1.5 7e-20 71.4 0.4 2.2 2 0 0 2 2 2 1 X-domain of DnaJ-containing SAP PF02037.27 KOO20824.1 - 0.00061 19.5 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 SAP domain ATG_C PF09333.11 KOO20824.1 - 0.0018 18.6 0.9 0.0018 18.6 0.9 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain LRR19-TM PF15176.6 KOO20824.1 - 0.065 13.2 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Armet PF10208.9 KOO20824.1 - 0.066 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding Arfaptin PF06456.13 KOO20824.1 - 0.1 12.2 1.8 0.35 10.4 0.4 2.0 2 0 0 2 2 2 0 Arfaptin-like domain DUF5347 PF17282.2 KOO20824.1 - 0.1 12.9 0.4 1.2 9.5 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5347) zf-C3HC4_3 PF13920.6 KOO20825.1 - 1.6e-15 56.6 9.0 3.1e-15 55.8 9.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO20825.1 - 9.8e-08 31.7 7.8 2.3e-07 30.6 7.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Tmemb_185A PF10269.9 KOO20825.1 - 2.2e-06 27.5 15.1 0.0057 16.4 5.5 2.4 2 0 0 2 2 2 2 Transmembrane Fragile-X-F protein zf-RING_2 PF13639.6 KOO20825.1 - 7e-06 26.3 9.9 1.3e-05 25.4 9.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KOO20825.1 - 2.6e-05 24.1 9.8 5.4e-05 23.1 9.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOO20825.1 - 5.1e-05 23.0 8.7 0.00011 22.0 8.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO20825.1 - 0.00043 20.1 8.3 0.0009 19.1 8.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF2457 PF10446.9 KOO20825.1 - 0.034 13.3 0.2 0.053 12.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF1644 PF07800.12 KOO20825.1 - 5.1 7.1 7.6 2 8.5 2.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) zf-RING_4 PF14570.6 KOO20825.1 - 9.2 6.2 9.4 22 4.9 9.4 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain EF-hand_1 PF00036.32 KOO20826.1 - 3.4e-19 66.9 8.4 1.5e-07 30.4 0.2 3.5 3 1 1 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO20826.1 - 1.1e-16 60.4 4.4 4e-11 42.6 0.2 3.2 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 KOO20826.1 - 5e-16 58.9 2.9 8.2e-12 45.4 0.1 2.8 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO20826.1 - 1.2e-15 56.0 2.5 1.1e-06 28.1 0.2 3.5 2 1 1 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KOO20826.1 - 2.5e-08 33.1 12.1 0.00024 20.5 0.5 3.6 4 2 1 5 5 5 2 EF hand EF-hand_9 PF14658.6 KOO20826.1 - 3.1e-07 30.6 0.1 1.1e-06 28.9 0.0 1.9 1 1 1 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 KOO20826.1 - 3.9e-05 23.5 0.3 0.00012 21.9 0.1 1.9 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 KOO20826.1 - 0.054 13.5 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) Aminotran_3 PF00202.21 KOO20827.1 - 3.7e-112 375.0 0.0 8.6e-112 373.7 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-III Orn_Arg_deC_N PF02784.16 KOO20827.1 - 6.6e-62 209.1 0.0 1e-61 208.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain PDZ_2 PF13180.6 KOO20827.1 - 1.3e-16 60.7 0.5 0.00041 20.6 0.0 4.6 4 1 0 4 4 4 3 PDZ domain PDZ_6 PF17820.1 KOO20827.1 - 4.6e-16 58.4 7.6 2.6e-08 33.6 0.2 4.6 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.24 KOO20827.1 - 1.7e-15 57.1 1.6 5.4e-07 29.9 0.0 4.4 4 0 0 4 4 4 3 PDZ domain DUF563 PF04577.14 KOO20827.1 - 1.1e-13 51.9 0.0 1.8e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Orn_DAP_Arg_deC PF00278.22 KOO20827.1 - 1.4e-11 44.5 0.0 4.9e-11 42.7 0.0 1.9 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Tricorn_PDZ PF14685.6 KOO20827.1 - 0.0073 16.3 0.3 23 5.0 0.0 3.8 4 0 0 4 4 4 0 Tricorn protease PDZ domain ABC_tran PF00005.27 KOO20828.1 - 1.6e-34 119.4 0.0 2.7e-34 118.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOO20828.1 - 3e-32 112.4 8.6 3.8e-32 112.0 8.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 KOO20828.1 - 4.5e-05 23.0 5.5 0.00022 20.7 0.1 2.9 2 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO20828.1 - 5e-05 23.8 1.9 0.00043 20.7 0.7 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOO20828.1 - 0.00044 20.5 0.4 0.0067 16.7 0.1 2.8 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KOO20828.1 - 0.00052 19.4 0.0 0.0011 18.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin ABC_ATPase PF09818.9 KOO20828.1 - 0.0018 17.2 0.0 0.0084 15.0 0.1 1.9 2 0 0 2 2 2 1 Predicted ATPase of the ABC class APS_kinase PF01583.20 KOO20828.1 - 0.0038 17.1 0.0 0.0086 16.0 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_29 PF13555.6 KOO20828.1 - 0.033 13.9 0.0 0.083 12.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 KOO20828.1 - 0.035 13.8 0.8 0.18 11.5 0.0 2.5 2 1 1 3 3 3 0 AAA domain CPT PF07931.12 KOO20828.1 - 0.06 13.2 0.0 0.21 11.4 0.0 2.0 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_5 PF07728.14 KOO20828.1 - 0.12 12.3 0.1 1.1 9.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 KOO20828.1 - 0.13 12.0 0.0 0.49 10.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 KOO20828.1 - 0.16 12.5 0.0 0.33 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 KOO20828.1 - 0.21 11.8 0.7 1.4 9.2 0.7 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 KOO20828.1 - 0.24 10.5 0.0 0.37 9.9 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_15 PF13175.6 KOO20828.1 - 0.33 10.6 0.0 0.46 10.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain HOIP-UBA PF16678.5 KOO20829.1 - 0.13 12.3 0.1 0.26 11.3 0.1 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair TPR_12 PF13424.6 KOO20830.1 - 4.6e-37 126.2 66.9 8.4e-10 38.8 1.4 8.4 3 3 6 9 9 9 8 Tetratricopeptide repeat TPR_10 PF13374.6 KOO20830.1 - 1.3e-31 107.5 46.1 4.4e-06 26.4 1.9 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat DUF218 PF02698.17 KOO20830.1 - 3.6e-14 52.9 0.0 1.6e-13 50.8 0.0 2.1 1 0 0 1 1 1 1 DUF218 domain TPR_16 PF13432.6 KOO20830.1 - 4.5e-08 33.6 39.1 0.062 14.0 7.7 7.4 4 3 2 6 6 6 4 Tetratricopeptide repeat RINGv PF12906.7 KOO20830.1 - 7e-05 22.9 7.5 0.00022 21.3 7.5 1.9 1 0 0 1 1 1 1 RING-variant domain TPR_7 PF13176.6 KOO20830.1 - 0.0001 22.1 15.6 0.99 9.6 0.1 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO20830.1 - 0.0027 18.0 3.7 9.1 6.9 0.1 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO20830.1 - 0.01 15.7 11.7 11 6.1 0.6 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO20830.1 - 0.18 12.0 20.3 4.9 7.5 0.5 6.1 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO20830.1 - 0.92 10.3 11.7 8 7.3 0.4 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO20830.1 - 0.93 10.5 31.4 2.2 9.3 1.4 6.4 5 1 1 6 6 6 0 Tetratricopeptide repeat zf-RING_2 PF13639.6 KOO20830.1 - 1.9 8.9 5.2 5 7.5 5.2 1.8 1 0 0 1 1 1 0 Ring finger domain YTH PF04146.15 KOO20831.1 - 3.9e-40 137.5 1.1 1.9e-39 135.3 1.1 1.9 1 1 0 1 1 1 1 YT521-B-like domain Aminotran_5 PF00266.19 KOO20832.1 - 7.7e-25 87.6 0.0 2.2e-24 86.1 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V ATP_bind_3 PF01171.20 KOO20832.1 - 2.5e-14 53.4 0.0 5.7e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 PP-loop family Aminotran_1_2 PF00155.21 KOO20832.1 - 0.21 10.7 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II DUF4741 PF15897.5 KOO20833.1 - 0.46 10.3 3.6 0.55 10.0 2.7 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4741) EF-hand_1 PF00036.32 KOO20834.1 - 4.9e-47 154.0 9.8 0.00021 20.6 0.1 9.6 7 2 2 9 9 9 9 EF hand EF-hand_7 PF13499.6 KOO20834.1 - 2.2e-45 153.0 4.1 1.2e-10 41.7 0.0 5.4 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.6 KOO20834.1 - 1e-43 143.5 14.9 0.00013 21.6 0.0 9.7 6 3 3 9 9 9 9 EF-hand domain EF-hand_5 PF13202.6 KOO20834.1 - 2e-37 125.0 12.3 0.00016 21.0 0.0 9.7 9 0 0 9 9 9 9 EF hand EF-hand_8 PF13833.6 KOO20834.1 - 4.6e-33 112.8 3.5 3.8e-07 29.8 0.0 6.4 5 1 1 6 6 6 5 EF-hand domain pair EF-hand_9 PF14658.6 KOO20834.1 - 2.7e-09 37.2 0.4 1 9.8 0.0 5.2 4 1 1 5 5 5 3 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO20834.1 - 3.9e-05 23.9 0.1 3.8 7.9 0.0 4.8 4 1 1 5 5 5 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO20834.1 - 0.00014 22.1 1.5 7.1 7.1 0.0 5.5 4 2 2 6 6 6 1 EF-hand domain EF-hand_2 PF09068.11 KOO20834.1 - 0.00026 21.1 0.1 2.2 8.4 0.1 4.5 4 2 0 4 4 4 1 EF hand Caleosin PF05042.13 KOO20834.1 - 0.0046 16.9 0.5 30 4.5 0.0 5.5 3 3 2 6 6 6 0 Caleosin related protein DUF3037 PF11236.8 KOO20834.1 - 0.018 15.5 0.3 0.23 11.9 0.2 2.8 3 2 0 3 3 3 0 Protein of unknown function (DUF3037) DUF5640 PF18692.1 KOO20834.1 - 0.079 13.0 0.0 1.3 9.1 0.0 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5640) DUF1798 PF08807.10 KOO20834.1 - 0.084 13.0 0.2 0.17 12.0 0.2 1.5 1 0 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) CC2-LZ PF16516.5 KOO20834.1 - 0.084 13.2 3.0 0.19 12.1 3.0 1.6 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator GrpE PF01025.19 KOO20834.1 - 0.088 12.5 1.5 0.15 11.7 1.5 1.4 1 0 0 1 1 1 0 GrpE EF-hand_10 PF14788.6 KOO20834.1 - 0.1 12.5 0.3 16 5.5 0.0 4.4 5 0 0 5 5 5 0 EF hand BLI1 PF17324.2 KOO20834.1 - 0.12 13.1 1.3 0.29 11.8 1.3 1.7 1 0 0 1 1 1 0 BLOC-1 interactor 1 DUF1664 PF07889.12 KOO20834.1 - 0.21 11.6 1.5 0.77 9.8 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Dockerin_1 PF00404.18 KOO20834.1 - 3.5 7.9 5.4 17 5.7 0.1 3.9 4 1 1 5 5 4 0 Dockerin type I domain DnaJ PF00226.31 KOO20835.1 - 1.1e-09 38.2 0.2 1.1e-07 31.9 0.0 3.4 3 0 0 3 3 3 1 DnaJ domain TPR_7 PF13176.6 KOO20835.1 - 0.00047 20.0 4.5 3.2 8.0 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO20835.1 - 0.0053 16.5 10.8 9.4 6.2 0.0 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO20835.1 - 0.0059 17.1 0.4 0.0059 17.1 0.4 6.6 6 2 1 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO20835.1 - 0.1 12.8 0.2 0.1 12.8 0.2 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat Hist_deacetyl PF00850.19 KOO20836.1 - 3.4e-80 269.8 0.2 4.6e-80 269.4 0.2 1.2 1 0 0 1 1 1 1 Histone deacetylase domain EF-hand_7 PF13499.6 KOO20837.1 - 5.7e-16 58.7 0.2 1.4e-15 57.5 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO20837.1 - 5.3e-15 53.8 3.7 5.4e-07 28.7 0.4 2.6 2 0 0 2 2 2 2 EF hand Ank_4 PF13637.6 KOO20837.1 - 1.5e-13 50.9 0.7 1.9e-08 34.7 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO20837.1 - 1.5e-11 44.7 1.1 1.2e-10 41.8 1.5 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) EF-hand_6 PF13405.6 KOO20837.1 - 5.3e-11 41.5 0.3 2.6e-06 26.9 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO20837.1 - 8e-11 40.9 3.2 1.1e-06 27.9 0.9 2.5 2 0 0 2 2 2 2 EF hand Ank_5 PF13857.6 KOO20837.1 - 1.1e-10 41.6 1.5 1.5e-07 31.6 0.3 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO20837.1 - 1.5e-09 37.3 0.3 3.3e-05 23.9 0.1 3.3 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KOO20837.1 - 3e-09 36.9 1.9 6.1e-08 32.8 1.3 2.8 2 0 0 2 2 2 1 Ankyrin repeat EF-hand_8 PF13833.6 KOO20837.1 - 8.8e-08 31.9 3.6 5.6e-07 29.3 1.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair ART PF01129.18 KOO20837.1 - 0.00013 21.4 0.0 0.00027 20.3 0.0 1.5 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase EF-hand_9 PF14658.6 KOO20837.1 - 0.00023 21.4 0.0 0.0005 20.3 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain ADPrib_exo_Tox PF03496.14 KOO20837.1 - 0.00031 20.2 0.0 0.00096 18.5 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme DnaJ_C PF01556.18 KOO20838.1 - 3.7e-36 124.4 0.1 1.2e-29 103.3 0.1 2.2 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.31 KOO20838.1 - 7.2e-22 77.3 0.4 1.3e-21 76.4 0.4 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOO20838.1 - 9.6e-08 32.3 7.2 9.6e-08 32.3 7.2 2.2 2 0 0 2 2 2 1 DnaJ central domain Lar_restr_allev PF14354.6 KOO20838.1 - 5.6 7.4 6.3 0.92 9.9 1.0 2.5 2 1 0 2 2 2 0 Restriction alleviation protein Lar Cullin PF00888.22 KOO20839.1 - 2.6e-194 647.4 0.9 3.2e-194 647.0 0.9 1.1 1 0 0 1 1 1 1 Cullin family Sod_Fe_C PF02777.18 KOO20839.1 - 1.2e-38 131.3 0.0 3.3e-38 129.9 0.0 1.8 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Gar1 PF04410.14 KOO20839.1 - 2.1e-34 118.5 0.1 7e-34 116.8 0.0 1.8 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region Sod_Fe_N PF00081.22 KOO20839.1 - 5.6e-24 84.4 1.1 1.3e-23 83.2 1.1 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Cullin_Nedd8 PF10557.9 KOO20839.1 - 6.4e-24 83.8 0.2 1.6e-23 82.5 0.2 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain KCNQ_channel PF03520.14 KOO20839.1 - 0.041 13.7 0.6 0.1 12.5 0.6 1.6 1 0 0 1 1 1 0 KCNQ voltage-gated potassium channel WD40 PF00400.32 KOO20840.1 - 1.4e-13 51.0 3.6 0.00023 21.9 0.0 3.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO20840.1 - 0.14 12.5 0.0 0.81 10.0 0.0 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_1 PF00036.32 KOO20841.1 - 2.1e-08 33.1 6.4 0.029 13.9 0.0 4.5 3 1 1 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO20841.1 - 4.4e-08 32.4 2.9 0.42 10.7 0.0 4.4 3 1 1 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 KOO20841.1 - 3.2e-07 30.7 3.6 0.00053 20.4 0.8 3.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO20841.1 - 9.7e-05 22.1 3.1 0.026 14.4 1.0 3.5 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO20841.1 - 0.00012 21.4 3.9 1.5 8.4 0.0 4.6 4 0 0 4 4 4 2 EF hand PRORP PF16953.5 KOO20841.1 - 0.012 15.1 0.9 0.027 14.0 0.4 1.8 1 1 1 2 2 2 0 Protein-only RNase P DUF573 PF04504.14 KOO20841.1 - 0.11 13.2 0.5 0.57 10.9 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function, DUF573 UPF0061 PF02696.14 KOO20842.1 - 6.4e-65 219.7 0.0 3.7e-62 210.6 0.0 2.9 2 1 0 2 2 2 2 Uncharacterized ACR, YdiU/UPF0061 family ShK PF01549.24 KOO20842.1 - 6.9e-05 23.3 2.4 0.00014 22.3 2.4 1.5 1 0 0 1 1 1 1 ShK domain-like Choline_transpo PF04515.12 KOO20844.1 - 1.4e-66 224.9 23.3 1.4e-66 224.9 23.3 1.9 2 0 0 2 2 2 1 Plasma-membrane choline transporter Myosin_head PF00063.21 KOO20845.1 - 4.5e-146 487.9 0.0 1.5e-145 486.1 0.0 1.6 1 1 0 1 1 1 1 Myosin head (motor domain) CBS PF00571.28 KOO20845.1 - 5e-05 23.7 1.9 0.0058 17.1 0.0 4.2 4 0 0 4 4 4 1 CBS domain AAA_16 PF13191.6 KOO20845.1 - 0.014 15.8 0.4 0.08 13.3 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain PB1 PF00564.24 KOO20845.1 - 0.023 14.6 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 PB1 domain IMS PF00817.20 KOO20846.1 - 1.6e-38 132.0 0.0 2.8e-38 131.3 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 KOO20846.1 - 1.5e-15 57.9 0.0 2.9e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain Cdd1 PF11731.8 KOO20846.1 - 0.0012 19.1 0.0 0.0062 16.7 0.0 2.1 2 0 0 2 2 2 1 Pathogenicity locus DUF1805 PF08827.11 KOO20846.1 - 0.0029 17.9 0.1 0.013 15.8 0.1 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1805) IMS_HHH PF11798.8 KOO20846.1 - 0.021 15.1 0.0 0.095 13.1 0.0 2.1 2 0 0 2 2 2 0 IMS family HHH motif FlgO PF17680.1 KOO20846.1 - 0.061 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 FlgO protein PMSR PF01625.21 KOO20849.1 - 4.4e-26 91.9 1.0 1.1e-25 90.6 1.0 1.5 1 1 0 1 1 1 1 Peptide methionine sulfoxide reductase Pkinase PF00069.25 KOO20850.1 - 6.4e-46 156.9 0.0 9.1e-46 156.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO20850.1 - 4.3e-26 91.7 0.0 8.1e-26 90.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase IPK PF03770.16 KOO20850.1 - 6.8e-15 55.4 0.0 1.2e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Kinase-like PF14531.6 KOO20850.1 - 0.009 15.4 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO20850.1 - 0.024 14.6 0.3 3.2 7.6 0.0 2.5 2 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO20850.1 - 0.041 12.7 0.0 0.062 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 KOO20850.1 - 0.062 12.9 0.0 5.3 6.6 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 FA_desaturase PF00487.24 KOO20851.1 - 3.5e-06 27.1 5.5 4.8e-06 26.6 5.5 1.1 1 0 0 1 1 1 1 Fatty acid desaturase OTU PF02338.19 KOO20852.1 - 4.8e-06 27.1 0.0 9e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease PH_12 PF16457.5 KOO20852.1 - 0.041 14.4 0.1 0.38 11.3 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain Aminotran_1_2 PF00155.21 KOO20853.1 - 3.3e-84 283.1 0.0 3.8e-84 282.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF1974 PF09317.11 KOO20854.1 - 2.8e-39 135.4 5.8 2.3e-38 132.4 5.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1974) Acyl-CoA_dh_N PF02771.16 KOO20854.1 - 6.7e-15 55.7 0.0 2.2e-14 54.1 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 KOO20854.1 - 1.3e-13 51.5 0.6 1.3e-13 51.5 0.6 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 KOO20854.1 - 0.0011 19.2 0.0 0.002 18.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain FAD_binding_3 PF01494.19 KOO20855.1 - 3.8e-21 75.7 0.3 7.4e-21 74.8 0.3 1.5 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KOO20855.1 - 3.8e-06 27.0 1.1 9.4e-06 25.8 0.3 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO20855.1 - 0.0044 16.6 1.3 0.0062 16.2 0.4 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOO20855.1 - 0.0045 15.7 0.0 0.0071 15.1 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 KOO20855.1 - 0.028 13.5 0.6 0.4 9.7 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 KOO20855.1 - 0.032 14.8 0.0 0.064 13.8 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOO20855.1 - 0.04 13.9 0.0 0.084 12.9 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 KOO20855.1 - 0.059 12.4 1.1 0.1 11.6 0.0 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 KOO20855.1 - 0.1 13.1 0.0 0.24 11.9 0.0 1.8 1 1 0 1 1 1 0 Putative NAD(P)-binding ApbA PF02558.16 KOO20855.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FMN_red PF03358.15 KOO20857.1 - 0.00032 20.5 0.1 0.00072 19.3 0.1 1.6 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 KOO20857.1 - 0.00061 19.6 0.0 0.00089 19.0 0.0 1.3 1 1 0 1 1 1 1 Flavodoxin-like fold DXP_synthase_N PF13292.6 KOO20858.1 - 1.3e-109 365.7 0.0 3e-108 361.1 0.0 2.1 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 KOO20858.1 - 2.6e-41 141.2 0.0 5.8e-41 140.1 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KOO20858.1 - 6.2e-24 84.2 0.4 1.6e-23 82.9 0.1 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 KOO20858.1 - 4.3e-06 26.6 0.2 1.6e-05 24.7 0.2 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 KOO20858.1 - 1e-05 24.6 0.1 1.8e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_N PF00456.21 KOO20858.1 - 3.6e-05 22.9 0.0 0.25 10.2 0.0 3.2 3 0 0 3 3 3 2 Transketolase, thiamine diphosphate binding domain AAA_12 PF13087.6 KOO20859.1 - 5.4e-61 205.7 0.0 1.6e-60 204.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain UPF1_Zn_bind PF09416.10 KOO20859.1 - 1.5e-53 180.8 0.5 4.6e-53 179.3 0.2 1.9 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_11 PF13086.6 KOO20859.1 - 3.1e-49 168.1 3.8 5.3e-30 105.1 0.5 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 KOO20859.1 - 3.6e-29 100.8 0.0 7.2e-29 99.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 KOO20859.1 - 1.4e-13 51.0 0.4 4.6e-12 46.1 0.4 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO20859.1 - 2.6e-10 40.8 0.1 8.7e-10 39.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 KOO20859.1 - 1.2e-05 24.8 1.5 8.9e-05 21.9 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 KOO20859.1 - 2.5e-05 24.3 0.0 4.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 KOO20859.1 - 0.0006 19.7 0.1 0.0014 18.5 0.0 1.7 2 0 0 2 2 1 1 Helicase PhoH PF02562.16 KOO20859.1 - 0.0031 17.0 0.1 0.0065 15.9 0.1 1.5 1 0 0 1 1 1 1 PhoH-like protein DEAD PF00270.29 KOO20859.1 - 0.0048 16.7 0.0 0.0083 15.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SRP54 PF00448.22 KOO20859.1 - 0.0062 16.2 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.14 KOO20859.1 - 0.018 15.0 0.1 0.033 14.2 0.1 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain NACHT PF05729.12 KOO20859.1 - 0.019 14.9 0.0 0.047 13.6 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 KOO20859.1 - 0.029 14.0 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 KOO20859.1 - 0.064 12.8 0.5 0.34 10.4 0.0 2.3 3 1 1 4 4 4 0 UvrD/REP helicase N-terminal domain AAA_5 PF07728.14 KOO20859.1 - 0.079 13.0 0.0 0.42 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PIF1 PF05970.14 KOO20859.1 - 0.082 12.1 0.1 7.8 5.5 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_22 PF13401.6 KOO20859.1 - 0.12 12.7 0.1 0.36 11.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO20859.1 - 0.17 12.3 0.5 0.49 10.8 0.1 2.1 2 1 0 2 2 1 0 AAA ATPase domain ATPase PF06745.13 KOO20859.1 - 0.18 11.1 0.0 0.73 9.1 0.0 1.8 2 0 0 2 2 2 0 KaiC Sec66 PF09802.9 KOO20860.1 - 2.4e-17 63.1 0.4 3.5e-17 62.5 0.4 1.2 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 GLTSCR1 PF15249.6 KOO20860.1 - 0.012 16.1 0.2 0.028 14.9 0.2 1.8 1 1 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein CX9C PF16860.5 KOO20861.1 - 2.6e-19 68.9 11.9 9.5e-12 44.7 2.1 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 KOO20861.1 - 2.1e-05 24.4 12.7 0.0033 17.4 1.7 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 KOO20861.1 - 0.0012 18.9 5.4 0.012 15.7 0.1 3.0 1 1 2 3 3 3 1 CHCH domain UPF0203 PF05254.12 KOO20861.1 - 0.019 15.2 9.4 0.78 10.0 3.4 3.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) Prot_inhib_II PF02428.15 KOO20861.1 - 0.099 13.1 0.4 0.099 13.1 0.4 2.4 2 1 1 3 3 3 0 Potato type II proteinase inhibitor family COX6B PF02297.17 KOO20861.1 - 0.12 12.6 14.3 0.12 12.6 0.9 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb NDUF_B7 PF05676.13 KOO20861.1 - 1.5 8.6 16.3 0.25 11.1 2.2 3.1 1 1 2 3 3 3 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX17 PF05051.13 KOO20861.1 - 7.1 7.1 19.5 0.12 12.7 2.7 3.4 1 1 3 4 4 4 0 Cytochrome C oxidase copper chaperone (COX17) GCK PF07802.11 KOO20861.1 - 8.5 6.9 10.7 12 6.4 1.3 2.6 1 1 2 3 3 3 0 GCK domain BTB_2 PF02214.22 KOO20863.1 - 8.8e-10 38.8 0.0 1.4e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Laminin_G_2 PF02210.24 KOO20864.1 - 3.4e-05 24.4 0.0 0.00013 22.6 0.0 2.0 2 0 0 2 2 2 1 Laminin G domain Laminin_G_1 PF00054.23 KOO20864.1 - 0.012 15.8 0.0 0.031 14.5 0.0 1.7 1 0 0 1 1 1 0 Laminin G domain HECT PF00632.25 KOO20867.1 - 5.8e-43 147.5 0.0 9e-43 146.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Nramp PF01566.18 KOO20869.1 - 2e-34 119.2 29.3 2.2e-33 115.7 17.1 3.3 3 1 0 3 3 3 2 Natural resistance-associated macrophage protein SKG6 PF08693.10 KOO20869.1 - 0.12 11.9 0.1 0.12 11.9 0.1 2.4 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Ion_trans_2 PF07885.16 KOO20869.1 - 0.64 10.0 0.1 0.64 10.0 0.1 3.5 4 0 0 4 4 4 0 Ion channel DUF3493 PF11998.8 KOO20869.1 - 2.8 8.2 8.3 15 5.8 0.8 3.9 3 0 0 3 3 3 0 Low psii accumulation1 / Rep27 Calreticulin PF00262.18 KOO20870.1 - 0.0014 17.6 3.2 0.0085 15.0 0.8 2.2 2 0 0 2 2 2 1 Calreticulin family Spc7 PF08317.11 KOO20870.1 - 0.014 14.3 5.4 0.021 13.7 5.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DAP10 PF07213.11 KOO20870.1 - 0.069 13.1 0.2 0.21 11.5 0.2 1.8 1 0 0 1 1 1 0 DAP10 membrane protein Lebercilin PF15619.6 KOO20870.1 - 0.072 12.7 4.6 0.15 11.7 4.6 1.5 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Spidroin_MaSp PF11260.8 KOO20870.1 - 0.23 11.7 3.7 1.4 9.2 0.4 2.9 3 0 0 3 3 3 0 Major ampullate spidroin 1 and 2 HAUS-augmin3 PF14932.6 KOO20870.1 - 2 8.0 7.1 3.1 7.3 7.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 SDA1 PF05285.12 KOO20871.1 - 4.3 6.7 12.8 5.2 6.4 12.8 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 KOO20871.1 - 8.1 4.6 8.6 11 4.1 8.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Vps51 PF08700.11 KOO20872.1 - 1.7e-24 85.7 5.3 5e-24 84.2 1.9 3.1 3 0 0 3 3 3 1 Vps51/Vps67 Sec5 PF15469.6 KOO20872.1 - 1.4e-12 47.8 3.9 8.4e-12 45.3 0.4 2.4 2 0 0 2 2 2 1 Exocyst complex component Sec5 Dor1 PF04124.12 KOO20872.1 - 2.2e-12 46.3 3.5 2.2e-12 46.3 3.5 2.1 2 0 0 2 2 2 1 Dor1-like family DUF4795 PF16043.5 KOO20872.1 - 3.4e-05 23.6 6.1 0.00018 21.2 1.3 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4795) COG2 PF06148.11 KOO20872.1 - 3.9e-05 23.8 2.4 3.9e-05 23.8 2.4 2.5 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps53_N PF04100.12 KOO20872.1 - 9.6e-05 21.5 2.0 9.6e-05 21.5 2.0 2.2 2 0 0 2 2 2 1 Vps53-like, N-terminal Vps54_N PF10475.9 KOO20872.1 - 0.0042 16.4 2.8 0.0042 16.4 2.8 1.7 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex COG5 PF10392.9 KOO20872.1 - 0.0082 16.3 0.8 0.0082 16.3 0.8 2.8 2 1 0 2 2 2 1 Golgi transport complex subunit 5 CENP-F_leu_zip PF10473.9 KOO20872.1 - 0.014 15.4 3.8 0.014 15.4 3.8 2.4 3 0 0 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Nsp1_C PF05064.13 KOO20872.1 - 0.023 14.5 3.5 0.32 10.8 0.5 2.5 2 0 0 2 2 2 0 Nsp1-like C-terminal region Enkurin PF13864.6 KOO20872.1 - 0.03 14.7 4.0 0.093 13.2 0.4 2.9 2 0 0 2 2 2 0 Calmodulin-binding RNase_3_N PF18497.1 KOO20872.1 - 0.035 14.3 0.3 0.65 10.2 0.2 2.8 3 0 0 3 3 3 0 Ribonuclease III N-terminal domain Phage_GP20 PF06810.11 KOO20872.1 - 0.086 12.6 3.9 0.71 9.7 0.1 3.1 3 0 0 3 3 3 0 Phage minor structural protein GP20 SKA1 PF07160.12 KOO20872.1 - 1.2 9.0 5.4 1.5 8.6 0.5 2.5 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Lebercilin PF15619.6 KOO20872.1 - 1.9 8.1 9.9 2 8.0 2.0 2.5 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF948 PF06103.11 KOO20872.1 - 4.7 7.5 8.4 38 4.6 0.2 4.1 4 1 1 5 5 3 0 Bacterial protein of unknown function (DUF948) ZapB PF06005.12 KOO20872.1 - 5.1 7.6 7.9 1.9 9.0 0.3 3.9 3 1 1 4 4 4 0 Cell division protein ZapB GAS PF13851.6 KOO20872.1 - 5.9 6.2 13.2 0.034 13.5 0.9 2.8 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding COG5 PF10392.9 KOO20873.1 - 0.35 11.1 7.1 0.5 10.6 1.7 3.3 2 1 0 2 2 2 0 Golgi transport complex subunit 5 Bromodomain PF00439.25 KOO20874.1 - 7.2e-22 77.3 0.0 8.7e-22 77.0 0.0 1.1 1 0 0 1 1 1 1 Bromodomain Nucleotid_trans PF03407.16 KOO20875.1 - 4.5e-31 108.5 0.0 8.9e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Bax1-I PF01027.20 KOO20875.1 - 5.9e-30 104.7 5.8 1e-29 103.9 5.8 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Peptidase_S41 PF03572.18 KOO20875.1 - 0.0023 17.5 0.0 0.0041 16.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 O-FucT PF10250.9 KOO20875.1 - 0.08 12.6 0.3 0.12 12.0 0.3 1.2 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase Glyco_transf_34 PF05637.12 KOO20875.1 - 0.16 11.7 0.1 0.78 9.4 0.0 1.9 2 0 0 2 2 2 0 galactosyl transferase GMA12/MNN10 family PDZ_6 PF17820.1 KOO20875.1 - 0.18 11.7 0.1 0.7 9.8 0.0 2.0 2 0 0 2 2 2 0 PDZ domain LRR_6 PF13516.6 KOO20876.1 - 2.1e-24 83.4 25.6 5.8e-05 22.8 0.2 9.4 9 1 1 10 10 10 7 Leucine Rich repeat Ank_2 PF12796.7 KOO20876.1 - 2.4e-15 56.9 3.4 1.2e-06 29.1 0.0 3.9 4 1 1 5 5 5 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO20876.1 - 9.1e-15 54.5 3.0 2e-09 37.5 0.1 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO20876.1 - 3.2e-14 53.1 1.1 2.4e-05 24.8 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO20876.1 - 1.5e-11 44.2 1.3 2.6e-05 24.5 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KOO20876.1 - 4.6e-11 41.9 0.1 0.014 15.9 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat LRR_1 PF00560.33 KOO20876.1 - 2.7e-07 30.2 3.0 17 6.4 0.1 7.1 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_4 PF12799.7 KOO20876.1 - 1.4e-05 25.3 19.8 0.81 10.2 1.3 6.2 4 2 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO20876.1 - 0.097 12.4 21.4 9.1 6.1 1.6 6.8 4 3 1 5 5 5 0 Leucine rich repeat Myosin_head PF00063.21 KOO20878.1 - 3.4e-216 719.6 0.0 5e-216 719.0 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) EF-hand_1 PF00036.32 KOO20878.1 - 9.5e-20 68.6 2.7 7e-07 28.3 0.0 4.8 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO20878.1 - 1.4e-16 60.1 6.0 4.3e-06 26.5 0.1 4.4 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_7 PF13499.6 KOO20878.1 - 1.5e-16 60.6 0.7 5.5e-11 42.8 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO20878.1 - 1.2e-13 49.8 4.6 3.6e-05 23.3 0.0 5.2 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KOO20878.1 - 6e-11 41.3 0.5 0.00023 20.5 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.7 KOO20878.1 - 7.2e-07 29.1 1.0 0.16 12.0 0.1 3.7 2 1 1 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO20878.1 - 0.0033 17.7 2.7 0.0057 17.0 0.1 2.6 2 1 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region AAA_22 PF13401.6 KOO20878.1 - 0.043 14.1 0.1 0.24 11.7 0.1 2.3 1 0 0 1 1 1 0 AAA domain Armet PF10208.9 KOO20878.1 - 0.073 13.0 1.4 0.44 10.5 0.7 2.6 3 0 0 3 3 3 0 Degradation arginine-rich protein for mis-folding EF-hand_9 PF14658.6 KOO20878.1 - 0.1 12.9 0.0 0.81 10.1 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain AAA_16 PF13191.6 KOO20878.1 - 0.33 11.3 0.1 0.33 11.3 0.1 4.1 5 0 0 5 5 5 0 AAA ATPase domain DUF3349 PF11829.8 KOO20878.1 - 6.9 7.5 6.4 84 4.0 0.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3349) PPR_1 PF12854.7 KOO20880.1 - 1.3e-18 66.4 0.0 3.5e-09 36.2 0.0 4.2 4 0 0 4 4 4 2 PPR repeat PPR_2 PF13041.6 KOO20880.1 - 3.8e-18 65.4 0.0 4.7e-12 45.9 0.0 3.4 2 1 1 3 3 3 3 PPR repeat family PPR PF01535.20 KOO20880.1 - 7e-16 57.3 0.2 0.00012 22.0 0.0 5.3 6 0 0 6 6 6 4 PPR repeat Methyltransf_4 PF02390.17 KOO20880.1 - 1.4e-14 53.9 0.0 2.8e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PPR_long PF17177.4 KOO20880.1 - 3e-10 39.8 0.0 1.2e-09 37.9 0.0 1.8 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 KOO20880.1 - 4.7e-10 39.4 0.0 5.4e-07 29.6 0.0 2.8 2 1 1 3 3 3 3 Pentatricopeptide repeat domain Methyltransf_25 PF13649.6 KOO20880.1 - 0.0073 17.0 0.0 0.025 15.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KOO20880.1 - 0.15 12.2 0.0 0.3 11.2 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Aldo_ket_red PF00248.21 KOO20881.1 - 1.9e-45 155.3 0.0 3.7e-33 115.0 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Sulfatase PF00884.23 KOO20882.1 - 3.2e-45 154.9 0.0 4.4e-45 154.4 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Nramp PF01566.18 KOO20882.1 - 3.7e-37 128.1 13.9 3.7e-37 128.1 13.9 2.0 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein Sulfatase_C PF14707.6 KOO20882.1 - 0.0075 17.0 0.0 0.015 16.1 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 KOO20882.1 - 0.019 14.6 0.0 0.92 9.0 0.0 2.2 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase HAD_2 PF13419.6 KOO20883.1 - 2.3e-23 83.2 0.0 5.7e-23 81.9 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO20883.1 - 9.7e-20 71.8 1.2 4.4e-19 69.6 1.2 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOO20883.1 - 1.4e-09 38.7 0.4 3.8e-09 37.2 0.4 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO20883.1 - 3.2e-06 27.1 0.1 8.5e-06 25.7 0.1 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 KOO20883.1 - 0.0024 18.0 0.0 0.094 12.8 0.0 2.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase EF-hand_1 PF00036.32 KOO20884.1 - 2.1e-09 36.3 0.0 0.00053 19.3 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO20884.1 - 2.7e-09 36.2 0.1 0.0015 18.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO20884.1 - 7.4e-09 35.9 0.0 1.2e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO20884.1 - 6.1e-07 28.7 0.2 0.017 14.6 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO20884.1 - 0.00067 19.5 0.0 0.0048 16.7 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain pair HTH_24 PF13412.6 KOO20884.1 - 0.041 13.5 0.1 0.12 11.9 0.1 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding PIG-L PF02585.17 KOO20884.1 - 0.076 13.7 0.2 0.51 11.0 0.1 2.4 1 1 0 1 1 1 0 GlcNAc-PI de-N-acetylase LRR_6 PF13516.6 KOO20885.1 - 7e-21 72.5 10.9 0.0012 18.7 0.1 8.1 8 0 0 8 8 8 6 Leucine Rich repeat LRR_4 PF12799.7 KOO20885.1 - 0.00021 21.6 7.7 0.0067 16.8 0.1 5.2 5 1 0 5 5 5 1 Leucine Rich repeats (2 copies) NACHT PF05729.12 KOO20885.1 - 0.00078 19.4 0.1 0.0067 16.4 0.1 2.4 1 1 0 1 1 1 1 NACHT domain LRR_8 PF13855.6 KOO20885.1 - 0.0011 18.7 3.5 1.4 8.7 0.0 5.4 5 1 0 5 5 5 1 Leucine rich repeat AAA_16 PF13191.6 KOO20885.1 - 0.038 14.4 0.5 0.34 11.3 0.0 3.0 2 0 0 2 2 2 0 AAA ATPase domain LRR_1 PF00560.33 KOO20885.1 - 0.081 13.5 0.2 17 6.4 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat AAA_22 PF13401.6 KOO20885.1 - 0.1 12.9 0.0 0.44 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain Aminotran_3 PF00202.21 KOO20886.1 - 4.5e-69 233.1 0.0 6.3e-69 232.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III APH PF01636.23 KOO20886.1 - 2.9e-14 53.6 1.8 2.9e-14 53.6 1.8 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family KH_1 PF00013.29 KOO20887.1 - 1.1e-10 41.2 0.5 2.8e-10 39.9 0.3 1.8 1 1 1 2 2 2 1 KH domain Secretin_N PF03958.17 KOO20887.1 - 0.1 13.0 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial type II/III secretion system short domain Ribosomal_L5e PF17144.4 KOO20888.1 - 1.1e-82 275.9 0.2 1.7e-82 275.2 0.2 1.3 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 KOO20888.1 - 4.3e-31 107.7 5.3 9.3e-31 106.6 5.3 1.6 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 KOO20888.1 - 0.046 14.1 0.0 0.099 13.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast C2-C2_1 PF11618.8 KOO20889.1 - 0.071 13.2 1.1 0.22 11.6 0.0 2.3 2 0 0 2 2 2 0 First C2 domain of RPGR-interacting protein 1 TSC22 PF01166.18 KOO20889.1 - 0.097 13.0 0.7 0.097 13.0 0.7 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family PLU-1 PF08429.11 KOO20889.1 - 0.32 10.1 17.0 0.14 11.3 14.5 1.6 1 1 1 2 2 2 0 PLU-1-like protein ANAPC4_WD40 PF12894.7 KOO20890.1 - 1.4e-12 47.7 0.2 0.085 13.2 0.0 5.3 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOO20890.1 - 4.9e-12 46.2 13.8 0.00044 21.0 0.2 6.9 6 1 0 6 6 6 3 WD domain, G-beta repeat eIF2A PF08662.11 KOO20890.1 - 5.4e-05 23.2 1.4 0.14 12.1 1.2 4.4 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOO20890.1 - 0.0026 16.8 0.9 6.5 5.6 0.0 4.1 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DPPIV_N PF00930.21 KOO20890.1 - 0.011 14.5 3.1 0.24 10.1 0.7 2.8 2 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region IKI3 PF04762.12 KOO20890.1 - 0.084 10.9 0.6 0.29 9.1 0.1 2.0 2 1 0 2 2 2 0 IKI3 family Sigma70_r2 PF04542.14 KOO20891.1 - 0.42 10.4 4.5 13 5.7 0.4 2.8 2 0 0 2 2 2 0 Sigma-70 region 2 IQ PF00612.27 KOO20892.1 - 0.031 14.1 5.8 0.91 9.5 0.4 3.1 2 0 0 2 2 2 0 IQ calmodulin-binding motif TLD PF07534.16 KOO20893.1 - 6.6e-18 65.3 0.2 1.5e-17 64.1 0.2 1.6 1 0 0 1 1 1 1 TLD AAA_16 PF13191.6 KOO20893.1 - 0.00018 21.9 0.0 0.00045 20.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 KOO20893.1 - 0.00026 21.1 0.0 0.00062 19.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.13 KOO20893.1 - 0.0036 16.4 0.0 0.0061 15.7 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 KOO20893.1 - 0.0091 15.9 0.0 0.28 11.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 KOO20893.1 - 0.013 14.9 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Roc PF08477.13 KOO20893.1 - 0.016 15.4 0.0 0.09 13.0 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 KOO20893.1 - 0.02 14.6 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 KOO20893.1 - 0.024 13.8 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATP_bind_1 PF03029.17 KOO20893.1 - 0.04 13.7 0.1 2.2 8.0 0.0 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 KOO20893.1 - 0.061 12.9 0.1 8.9 5.8 0.1 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain PPV_E1_C PF00519.17 KOO20893.1 - 0.061 12.1 0.0 0.09 11.6 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase AAA_7 PF12775.7 KOO20893.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 KOO20893.1 - 0.12 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 NTPase RNA_helicase PF00910.22 KOO20893.1 - 0.13 12.7 0.0 0.35 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF5600 PF18150.1 KOO20895.1 - 5.9e-35 120.1 0.2 1.1e-34 119.3 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 KOO20895.1 - 4.1e-15 55.6 0.0 1.2e-14 54.1 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dynamin_N PF00350.23 KOO20895.1 - 1.1e-12 48.3 0.0 1.5e-10 41.4 0.0 2.3 1 1 0 1 1 1 1 Dynamin family EHD_N PF16880.5 KOO20895.1 - 7.3e-09 35.4 0.0 1.5e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.23 KOO20895.1 - 1.1e-08 35.2 0.0 2.1e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 KOO20895.1 - 0.027 14.7 0.0 1.8 8.8 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 KOO20895.1 - 0.031 14.5 0.0 0.061 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 KOO20895.1 - 0.033 13.7 0.0 0.46 10.0 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain TniB PF05621.11 KOO20895.1 - 0.035 13.5 0.1 8.9 5.7 0.1 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Gtr1_RagA PF04670.12 KOO20895.1 - 0.07 12.5 0.0 0.42 9.9 0.0 1.9 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region EF-hand_1 PF00036.32 KOO20895.1 - 0.13 11.9 0.5 0.48 10.1 0.0 2.3 2 0 0 2 2 2 0 EF hand RsgA_GTPase PF03193.16 KOO20895.1 - 0.18 11.7 0.0 29 4.5 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase AIG1 PF04548.16 KOO20895.1 - 0.2 11.0 0.0 0.36 10.1 0.0 1.4 1 0 0 1 1 1 0 AIG1 family zf-C3HC4_3 PF13920.6 KOO20896.1 - 1.9e-15 56.5 6.0 2.8e-15 55.9 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO20896.1 - 8.2e-05 22.4 7.4 0.00014 21.7 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO20896.1 - 0.00014 22.1 8.5 0.00025 21.3 8.5 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KOO20896.1 - 0.0012 18.7 8.2 0.0022 17.8 8.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOO20896.1 - 0.0012 18.8 8.7 0.0019 18.1 8.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOO20896.1 - 0.053 13.4 9.1 0.086 12.7 9.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 KOO20896.1 - 0.3 10.8 3.1 0.64 9.7 3.1 1.5 1 0 0 1 1 1 0 P-11 zinc finger Bact_lectin PF18483.1 KOO20897.1 - 4e-13 49.8 0.0 6.8e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 KOO20897.1 - 2.4e-11 43.6 0.0 4.4e-10 39.5 0.0 2.5 1 1 0 1 1 1 1 Legume lectin domain HTH_Crp_2 PF13545.6 KOO20898.1 - 0.056 13.4 0.0 3 7.9 0.0 2.6 2 1 1 3 3 3 0 Crp-like helix-turn-helix domain Rrp40_N PF18311.1 KOO20898.1 - 0.18 11.7 0.0 0.45 10.5 0.0 1.6 1 0 0 1 1 1 0 Exosome complex exonuclease Rrp40 N-terminal domain CCDC-167 PF15188.6 KOO20900.1 - 2.3 8.6 9.9 1.3 9.4 3.8 2.9 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Phage_lysis PF03245.13 KOO20901.1 - 0.05 13.7 0.1 0.1 12.7 0.1 1.5 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein WD40 PF00400.32 KOO20903.1 - 6.5e-19 67.9 15.4 0.0018 19.1 0.3 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO20903.1 - 3e-07 30.6 3.6 0.036 14.4 0.3 4.2 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Aa_trans PF01490.18 KOO20904.1 - 5.4e-18 64.9 19.0 9.5e-18 64.1 19.0 1.3 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Peptidase_M41 PF01434.18 KOO20905.1 - 3.4e-63 213.0 1.4 5.6e-63 212.3 1.4 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KOO20905.1 - 7.4e-43 146.1 0.0 2e-42 144.7 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO20905.1 - 8.4e-14 51.1 0.4 2.6e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 AAA+ lid domain TIP49 PF06068.13 KOO20905.1 - 7e-06 25.5 0.0 1.4e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 KOO20905.1 - 1.9e-05 24.7 0.0 5.3e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO20905.1 - 2.6e-05 24.6 0.9 0.003 17.9 0.2 3.0 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 KOO20905.1 - 5.7e-05 22.9 0.0 0.00016 21.5 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOO20905.1 - 0.00019 21.7 0.1 0.029 14.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 KOO20905.1 - 0.0063 16.0 0.4 0.56 9.6 0.2 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_7 PF12775.7 KOO20905.1 - 0.0081 15.7 0.0 0.038 13.5 0.0 1.9 1 1 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 KOO20905.1 - 0.0091 15.7 0.2 0.023 14.5 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 KOO20905.1 - 0.022 15.3 0.0 0.057 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 KOO20905.1 - 0.023 14.8 0.0 0.07 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 KOO20905.1 - 0.025 14.0 0.3 0.1 12.0 0.2 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 KOO20905.1 - 0.046 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO20905.1 - 0.047 13.8 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO20905.1 - 0.049 13.5 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.6 KOO20905.1 - 0.054 13.9 0.4 0.13 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 KOO20905.1 - 0.069 12.8 0.1 0.69 9.6 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain SpoU_sub_bind PF08032.12 KOO20905.1 - 0.073 13.4 0.1 12 6.2 0.0 2.7 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding AAA_14 PF13173.6 KOO20905.1 - 0.098 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsA PF14450.6 KOO20905.1 - 0.14 12.6 0.2 0.48 10.9 0.2 1.9 1 1 0 1 1 1 0 Cell division protein FtsA AAA_25 PF13481.6 KOO20905.1 - 0.16 11.5 1.9 0.61 9.6 0.4 2.4 2 1 1 3 3 3 0 AAA domain ATPase PF06745.13 KOO20905.1 - 0.16 11.3 0.1 0.86 8.9 0.0 2.0 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.9 KOO20905.1 - 0.19 10.9 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) V-ATPase_G_2 PF16999.5 KOO20905.1 - 2.1 8.8 6.4 1.4 9.4 4.3 1.8 2 0 0 2 2 1 0 Vacuolar (H+)-ATPase G subunit LRR_6 PF13516.6 KOO20906.1 - 6.4e-26 88.2 37.9 0.00013 21.7 0.2 14.4 15 0 0 15 15 15 9 Leucine Rich repeat LRR_1 PF00560.33 KOO20906.1 - 1.6e-12 46.1 7.4 23 6.1 0.3 11.1 12 0 0 12 12 12 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO20906.1 - 9.2e-08 32.3 16.8 17 6.0 0.0 10.1 9 1 0 9 9 9 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO20906.1 - 4.8e-06 26.2 18.5 12 5.8 0.0 10.0 10 2 1 11 11 11 3 Leucine rich repeat UPF0181 PF03701.14 KOO20906.1 - 0.065 12.9 2.4 27 4.5 0.0 4.0 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0181) MORN PF02493.20 KOO20906.1 - 0.14 12.1 4.0 2.6 8.1 0.2 3.2 3 0 0 3 3 3 0 MORN repeat SpoU_sub_bind PF08032.12 KOO20906.1 - 0.14 12.4 0.1 93 3.4 0.0 4.4 5 0 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding TA_inhibitor PF17574.2 KOO20906.1 - 2.7 8.1 7.8 14 5.8 0.1 4.3 5 0 0 5 5 5 0 Inhibitor of toxin/antitoxin system (Gp4.5) Cellulase PF00150.18 KOO20907.1 - 5.6e-30 104.7 0.0 1.5e-24 86.9 0.0 2.1 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) ketoacyl-synt PF00109.26 KOO20908.1 - 1.6e-53 181.9 5.8 2.4e-53 181.3 5.8 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOO20908.1 - 3.9e-31 107.5 0.3 7.3e-31 106.6 0.3 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 KOO20908.1 - 0.0015 17.9 1.6 0.0025 17.2 1.6 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain FKBP_C PF00254.28 KOO20909.1 - 1.2e-18 67.2 0.0 1.8e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 KOO20909.1 - 5.6e-09 36.9 0.0 1.6e-08 35.4 0.0 1.6 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase 2OG-FeII_Oxy_3 PF13640.6 KOO20910.1 - 1.9e-13 51.1 0.0 3.4e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO20910.1 - 2e-09 37.8 15.1 3.5e-06 27.4 2.3 3.2 3 0 0 3 3 3 2 ShK domain-like WW PF00397.26 KOO20910.1 - 2.8e-09 36.9 2.1 6.7e-09 35.7 2.1 1.7 1 0 0 1 1 1 1 WW domain DUF4164 PF13747.6 KOO20911.1 - 0.37 11.1 5.2 0.87 9.9 5.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) DHC_N1 PF08385.12 KOO20912.1 - 4.3e-177 590.2 1.3 4.3e-177 590.2 1.3 2.4 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 KOO20912.1 - 5.7e-132 439.6 0.0 5.3e-131 436.4 0.0 2.6 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO20912.1 - 1.2e-104 350.6 3.8 1.2e-104 350.6 3.8 4.0 3 1 1 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO20912.1 - 2e-101 338.7 0.2 6.2e-101 337.1 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KOO20912.1 - 8.2e-89 297.8 0.0 5e-88 295.3 0.0 2.3 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain MT PF12777.7 KOO20912.1 - 4.5e-79 266.0 13.0 9.4e-79 264.9 13.0 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.7 KOO20912.1 - 1.2e-69 233.9 0.0 3.3e-69 232.4 0.0 1.9 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_7 PF12775.7 KOO20912.1 - 5e-64 215.1 3.9 1.8e-60 203.5 0.1 4.6 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KOO20912.1 - 1.5e-43 148.4 0.0 3.4e-43 147.3 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO20912.1 - 7.1e-35 119.7 0.0 2.7e-34 117.8 0.0 2.1 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 KOO20912.1 - 3.6e-27 94.5 0.1 1.3e-26 92.7 0.1 2.1 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 KOO20912.1 - 6e-20 71.6 0.2 2.3e-19 69.7 0.2 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO20912.1 - 5.6e-12 45.8 0.0 0.0045 17.0 0.0 5.3 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO20912.1 - 0.00032 21.0 0.0 22 5.3 0.0 4.4 4 0 0 4 4 4 0 AAA domain AAA PF00004.29 KOO20912.1 - 0.0089 16.5 0.6 7.8 6.9 0.0 3.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KOO20912.1 - 0.05 14.2 0.2 21 5.7 0.0 4.2 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.6 KOO20912.1 - 0.16 12.3 5.2 0.73 10.2 0.0 3.6 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 KOO20912.1 - 1.6 8.4 11.3 11 5.7 0.1 4.4 4 0 0 4 4 4 0 AAA domain Nup54 PF13874.6 KOO20912.1 - 5.5 7.1 6.3 46 4.1 2.5 3.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 HATPase_c_3 PF13589.6 KOO20913.1 - 0.022 14.6 0.1 0.043 13.7 0.1 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FmiP_Thoc5 PF09766.9 KOO20914.1 - 9.4e-14 51.5 0.0 3.8e-13 49.5 0.0 1.8 1 1 0 1 1 1 1 Fms-interacting protein/Thoc5 DHR10 PF18595.1 KOO20914.1 - 0.21 11.6 7.0 1.3 9.1 0.8 2.4 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain YtxH PF12732.7 KOO20914.1 - 1.1 9.9 8.1 20 5.8 8.1 2.4 1 1 0 1 1 1 0 YtxH-like protein DUF3584 PF12128.8 KOO20914.1 - 1.4 6.4 8.0 0.94 6.9 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF4813 PF16072.5 KOO20914.1 - 3.7 7.1 6.8 7.8 6.1 6.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Spc7 PF08317.11 KOO20914.1 - 5.2 5.8 6.0 12 4.6 0.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 KOO20914.1 - 6.8 6.8 12.2 4 7.5 0.5 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Polyketide_cyc2 PF10604.9 KOO20915.1 - 3.4e-12 46.8 0.0 4.2e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 KOO20915.1 - 9.2e-09 35.6 0.0 1.3e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.13 KOO20915.1 - 4.7e-05 23.1 0.0 6.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Carbon monoxide dehydrogenase subunit G (CoxG) DUF2917 PF11142.8 KOO20916.1 - 0.029 13.7 0.1 0.3 10.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2917) SNARE_assoc PF09335.11 KOO20916.1 - 0.11 13.0 1.6 0.18 12.3 1.6 1.3 1 0 0 1 1 1 0 SNARE associated Golgi protein Keratin_2_head PF16208.5 KOO20916.1 - 6.9 6.8 37.0 8.5 6.5 18.8 2.2 2 0 0 2 2 2 0 Keratin type II head Methyltransf_21 PF05050.12 KOO20918.1 - 4e-10 40.0 0.0 5.3e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_23 PF13489.6 KOO20918.1 - 0.11 12.3 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain BCDHK_Adom3 PF10436.9 KOO20919.1 - 5e-21 75.2 0.1 7.2e-21 74.7 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KOO20919.1 - 1.6e-09 38.2 0.0 3.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOO20919.1 - 0.0027 17.5 0.0 0.005 16.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TPR_19 PF14559.6 KOO20920.1 - 3.3e-36 123.6 114.5 1.1e-05 25.8 3.8 20.0 15 5 7 22 22 22 11 Tetratricopeptide repeat TPR_14 PF13428.6 KOO20920.1 - 5.4e-24 82.8 116.3 0.00059 20.4 1.2 25.2 17 7 13 30 30 28 8 Tetratricopeptide repeat TPR_1 PF00515.28 KOO20920.1 - 3.2e-22 77.4 55.4 0.00065 19.4 0.1 16.2 18 0 0 18 18 17 9 Tetratricopeptide repeat TPR_2 PF07719.17 KOO20920.1 - 3.1e-21 73.7 85.9 0.00076 19.4 0.0 21.3 23 0 0 23 23 20 8 Tetratricopeptide repeat TPR_16 PF13432.6 KOO20920.1 - 4.4e-21 75.3 89.9 0.00058 20.5 2.1 16.3 12 2 5 18 18 17 8 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO20920.1 - 8.4e-15 54.8 58.4 8.4e-06 25.9 1.8 12.6 10 2 3 13 13 13 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KOO20920.1 - 5.2e-10 38.7 43.7 0.21 11.9 0.3 15.3 16 0 0 16 16 15 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO20920.1 - 3.8e-06 26.9 28.1 0.066 13.6 0.1 10.2 11 1 1 12 12 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO20920.1 - 2.3e-05 24.7 70.2 0.062 14.0 0.1 18.1 22 0 0 22 22 17 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO20920.1 - 2.4e-05 24.1 52.6 0.55 10.4 0.0 15.7 16 1 1 17 17 15 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO20920.1 - 2.8e-05 24.2 46.0 0.036 14.2 0.7 9.6 7 3 2 9 9 9 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOO20920.1 - 0.00041 20.0 30.2 1.3 8.8 0.1 10.9 11 1 2 13 13 13 3 TPR repeat TPR_15 PF13429.6 KOO20920.1 - 0.00067 19.0 2.0 0.00067 19.0 2.0 8.1 6 3 2 8 8 8 2 Tetratricopeptide repeat TPR_21 PF09976.9 KOO20920.1 - 0.0013 18.5 6.3 0.0013 18.5 6.3 9.0 7 3 2 9 9 9 2 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 KOO20920.1 - 0.0045 17.3 96.6 0.19 12.1 2.0 16.7 12 5 7 19 19 17 4 Tetratricopeptide repeat FAT PF02259.23 KOO20920.1 - 0.022 14.0 11.2 0.71 9.0 1.6 4.2 4 1 0 5 5 5 0 FAT domain TPR_20 PF14561.6 KOO20920.1 - 0.028 14.8 0.8 0.028 14.8 0.8 12.2 11 4 5 17 17 14 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO20920.1 - 0.051 13.7 0.4 0.051 13.7 0.4 5.4 6 0 0 6 6 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 KOO20920.1 - 0.14 12.9 0.0 0.14 12.9 0.0 12.7 15 1 0 15 15 10 0 Tetratricopeptide repeat ChAPs PF09295.10 KOO20920.1 - 0.19 10.7 12.6 0.19 10.7 0.1 4.4 4 1 1 5 5 5 0 ChAPs (Chs5p-Arf1p-binding proteins) Alkyl_sulf_dimr PF14863.6 KOO20920.1 - 0.67 10.4 17.3 1.5 9.2 0.2 5.8 5 1 0 5 5 5 0 Alkyl sulfatase dimerisation YfiO PF13525.6 KOO20920.1 - 0.93 9.2 12.1 0.62 9.7 0.1 5.0 6 0 0 6 6 5 0 Outer membrane lipoprotein DUF3379 PF11859.8 KOO20920.1 - 2.4 7.4 8.6 1.4 8.2 6.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3379) PPR_2 PF13041.6 KOO20921.1 - 7.2e-05 22.9 0.0 0.1 12.8 0.0 2.7 1 1 1 2 2 2 2 PPR repeat family TF_Zn_Ribbon PF08271.12 KOO20923.1 - 1.7e-05 24.2 4.3 3.2e-05 23.3 4.3 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding ASL_C PF08328.11 KOO20923.1 - 0.024 14.7 0.0 0.068 13.3 0.0 1.8 1 1 0 1 1 1 0 Adenylosuccinate lyase C-terminal YPEB PF14620.6 KOO20923.1 - 0.029 13.7 0.1 0.042 13.2 0.1 1.2 1 0 0 1 1 1 0 YpeB sporulation SVWC PF15430.6 KOO20923.1 - 0.043 14.1 1.2 0.099 12.9 1.2 1.5 1 0 0 1 1 1 0 Single domain von Willebrand factor type C HTH_24 PF13412.6 KOO20923.1 - 0.078 12.6 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_40 PF14493.6 KOO20923.1 - 0.087 13.3 0.2 0.43 11.1 0.0 2.2 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_AraC PF00165.23 KOO20923.1 - 0.13 12.4 0.0 0.38 10.9 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family TetR_N PF00440.23 KOO20923.1 - 0.14 12.0 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_IclR PF09339.10 KOO20923.1 - 0.2 11.5 1.7 0.69 9.8 0.2 2.6 2 1 1 3 3 3 0 IclR helix-turn-helix domain LRR_6 PF13516.6 KOO20924.1 - 7.9e-13 47.4 13.8 7.4e-07 28.7 0.3 5.8 6 0 0 6 6 6 4 Leucine Rich repeat Skp1 PF01466.19 KOO20924.1 - 0.00096 19.2 0.0 0.0052 16.9 0.0 2.2 2 0 0 2 2 2 1 Skp1 family, dimerisation domain LRR_4 PF12799.7 KOO20924.1 - 0.0015 18.9 0.9 0.97 9.9 0.1 3.1 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO20924.1 - 0.026 15.0 0.1 59 4.8 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO20924.1 - 0.098 12.4 1.5 7.1 6.5 0.0 3.0 2 1 0 2 2 2 0 Leucine rich repeat VDE PF07137.11 KOO20926.1 - 1.9e-66 224.0 0.1 2.3e-66 223.8 0.1 1.1 1 0 0 1 1 1 1 VDE lipocalin domain Septin PF00735.18 KOO20927.1 - 5.5e-61 206.3 0.0 3.7e-52 177.4 0.0 2.1 2 0 0 2 2 2 2 Septin AAA_16 PF13191.6 KOO20927.1 - 3.1e-05 24.4 5.4 3.1e-05 24.4 5.4 2.0 2 1 0 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.27 KOO20927.1 - 3.1e-05 23.6 0.1 1.2 8.7 0.0 3.3 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 KOO20927.1 - 0.00055 20.2 0.3 0.0017 18.6 0.1 1.9 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 KOO20927.1 - 0.0018 17.5 0.0 0.0044 16.2 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain Dynamin_N PF00350.23 KOO20927.1 - 0.0027 17.8 2.9 0.019 15.0 0.8 2.8 2 1 0 2 2 2 1 Dynamin family ABC_tran PF00005.27 KOO20927.1 - 0.0038 17.7 0.1 0.0092 16.5 0.1 1.6 1 0 0 1 1 1 1 ABC transporter NACHT PF05729.12 KOO20927.1 - 0.0062 16.5 0.0 0.015 15.2 0.0 1.7 1 0 0 1 1 1 1 NACHT domain MMR_HSR1 PF01926.23 KOO20927.1 - 0.0068 16.5 0.0 1.8 8.6 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase T2SSE PF00437.20 KOO20927.1 - 0.0077 15.3 0.0 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein MobB PF03205.14 KOO20927.1 - 0.0089 15.9 0.0 0.02 14.8 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B RsgA_GTPase PF03193.16 KOO20927.1 - 0.013 15.5 1.4 5.6 6.8 0.0 3.4 3 1 0 4 4 4 0 RsgA GTPase Roc PF08477.13 KOO20927.1 - 0.017 15.4 0.0 0.039 14.2 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 KOO20927.1 - 0.026 14.5 0.1 0.045 13.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KOO20927.1 - 0.036 13.6 0.0 0.069 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Ras PF00071.22 KOO20927.1 - 0.042 13.5 0.4 0.22 11.1 0.0 2.4 2 1 1 3 3 3 0 Ras family TniB PF05621.11 KOO20927.1 - 0.065 12.6 0.4 0.13 11.6 0.0 1.8 2 1 0 2 2 2 0 Bacterial TniB protein Pox_A32 PF04665.12 KOO20927.1 - 0.066 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein ATPase_2 PF01637.18 KOO20927.1 - 0.09 12.7 0.3 0.22 11.4 0.1 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 KOO20927.1 - 0.098 12.4 0.0 3.4 7.4 0.0 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 KOO20927.1 - 0.33 10.7 1.9 12 5.6 0.1 3.2 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF16 PF01519.16 KOO20927.1 - 0.43 11.1 3.1 0.66 10.5 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 IHABP4_N PF16174.5 KOO20927.1 - 1.9 9.1 11.3 4.4 7.9 11.3 1.6 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Seryl_tRNA_N PF02403.22 KOO20927.1 - 3 8.1 9.0 2.2 8.5 6.7 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ERM PF00769.19 KOO20927.1 - 3.9 7.2 18.6 0.79 9.5 13.8 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Atg14 PF10186.9 KOO20927.1 - 5.2 6.1 9.9 9.4 5.2 9.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SlyX PF04102.12 KOO20927.1 - 5.5 7.7 6.4 17 6.1 1.5 3.1 2 1 1 3 3 3 0 SlyX RGS PF00615.19 KOO20928.1 - 9.5e-23 80.7 0.3 9.6e-09 35.5 0.0 3.1 3 0 0 3 3 3 3 Regulator of G protein signaling domain RecR PF02132.15 KOO20928.1 - 9.2 5.9 9.0 12 5.5 0.1 3.4 3 0 0 3 3 3 0 RecR protein CLTH PF10607.9 KOO20929.1 - 2.1e-10 40.7 0.0 1.7e-09 37.7 0.0 2.2 1 1 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain DASH_Spc19 PF08287.11 KOO20930.1 - 1.5 8.7 32.3 0.095 12.6 11.5 2.4 2 0 0 2 2 2 0 Spc19 LRR_9 PF14580.6 KOO20931.1 - 1.1e-13 51.0 0.2 4.2e-09 36.2 0.0 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 KOO20931.1 - 4.9e-13 49.0 7.6 2e-05 24.8 0.2 3.8 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO20931.1 - 1.6e-10 40.6 12.1 3.3e-05 23.6 0.4 2.8 2 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 KOO20931.1 - 4.2e-05 23.3 6.4 1 9.6 0.0 4.7 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 KOO20931.1 - 0.061 13.9 8.3 33 5.6 0.1 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_2 PF07723.13 KOO20931.1 - 0.072 13.8 0.3 22 5.9 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich Repeat Anoctamin PF04547.12 KOO20932.1 - 0.00081 18.3 1.0 0.00081 18.3 1.0 3.0 3 0 0 3 3 3 2 Calcium-activated chloride channel DUF2291 PF10054.9 KOO20932.1 - 0.71 9.6 5.0 8.7 6.0 1.0 2.7 2 0 0 2 2 2 0 Predicted periplasmic lipoprotein (DUF2291) Ion_trans PF00520.31 KOO20933.1 - 1.3e-29 103.2 7.0 2.1e-29 102.5 7.0 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO20933.1 - 0.00033 19.5 7.5 0.0091 14.7 0.9 2.8 3 0 0 3 3 3 2 Polycystin cation channel DUF5090 PF17009.5 KOO20933.1 - 1.3 9.0 4.9 3 7.7 4.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) zf-RING_2 PF13639.6 KOO20934.1 - 4.2e-10 39.8 8.0 6.6e-08 32.8 3.2 2.3 1 1 1 2 2 2 2 Ring finger domain zf-rbx1 PF12678.7 KOO20934.1 - 3.4e-09 36.8 2.5 6.1e-09 36.0 2.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KOO20934.1 - 7.1e-05 22.7 2.8 0.00026 20.9 2.8 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOO20934.1 - 0.00016 21.4 8.1 0.00021 21.1 2.0 2.4 1 1 2 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO20934.1 - 0.00016 21.4 3.1 0.0023 17.7 3.1 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO20934.1 - 0.0026 17.6 1.5 0.84 9.5 0.5 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 KOO20934.1 - 0.0045 17.1 2.3 0.041 14.0 2.3 2.1 1 1 0 1 1 1 1 RING-variant domain zf-ANAPC11 PF12861.7 KOO20934.1 - 0.011 15.7 0.1 0.011 15.7 0.1 1.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 KOO20934.1 - 0.023 14.4 4.4 1.3 8.8 1.4 2.4 2 0 0 2 2 2 0 RING-like zinc finger zf-P11 PF03854.14 KOO20934.1 - 0.031 13.9 2.3 0.13 11.9 0.1 2.2 2 0 0 2 2 2 0 P-11 zinc finger zf-RING_5 PF14634.6 KOO20934.1 - 0.15 12.0 4.9 1.3 9.0 4.1 2.2 1 1 1 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 KOO20934.1 - 0.15 11.9 6.0 0.75 9.7 0.6 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 KOO20934.1 - 1.2 9.3 4.2 6.7 7.0 4.2 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Rad50_zn_hook PF04423.14 KOO20934.1 - 2.9 7.8 4.5 23 4.9 0.1 3.1 4 0 0 4 4 4 0 Rad50 zinc hook motif GAGA PF09237.11 KOO20934.1 - 4 7.3 4.6 14 5.6 1.0 2.7 2 0 0 2 2 2 0 GAGA factor Ank_2 PF12796.7 KOO20935.1 - 1.6e-20 73.4 0.0 3.9e-13 49.8 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO20935.1 - 5.4e-16 58.4 0.4 5.2e-11 42.6 0.2 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO20935.1 - 3.4e-15 56.2 1.6 1.1e-08 35.5 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO20935.1 - 4.5e-12 45.8 0.2 0.00095 19.5 0.1 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO20935.1 - 2.2e-08 33.7 0.0 0.0068 16.8 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeat Aa_trans PF01490.18 KOO20935.1 - 8.7e-05 21.4 0.1 0.00012 20.9 0.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF4231 PF14015.6 KOO20935.1 - 0.00026 21.4 0.2 0.0045 17.4 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF4231) EF-hand_5 PF13202.6 KOO20935.1 - 0.017 14.6 0.0 0.046 13.2 0.0 1.7 1 0 0 1 1 1 0 EF hand Methyltrans_SAM PF10672.9 KOO20935.1 - 0.024 13.8 0.0 0.047 12.8 0.0 1.4 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase EF-hand_1 PF00036.32 KOO20935.1 - 0.18 11.4 0.0 0.53 10.0 0.0 1.8 1 0 0 1 1 1 0 EF hand Ion_trans PF00520.31 KOO20936.1 - 9.7e-20 70.8 14.6 2.6e-09 36.7 1.5 3.4 3 0 0 3 3 3 3 Ion transport protein Ion_trans_2 PF07885.16 KOO20936.1 - 9.7e-19 67.1 20.0 3.6e-09 36.4 0.9 4.2 4 1 0 4 4 4 3 Ion channel cNMP_binding PF00027.29 KOO20936.1 - 9e-15 54.5 0.4 1.1e-09 38.2 0.4 3.5 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain Med26 PF08711.11 KOO20936.1 - 0.15 12.1 0.0 0.45 10.6 0.0 1.8 1 0 0 1 1 1 0 TFIIS helical bundle-like domain Metallophos PF00149.28 KOO20937.1 - 1.1e-16 62.0 0.1 1.3e-14 55.2 0.0 2.7 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 KOO20937.1 - 3.7e-13 50.1 0.7 3.1e-12 47.2 0.4 2.5 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 KOO20937.1 - 0.00016 21.9 0.0 0.00024 21.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PGA_cap PF09587.10 KOO20937.1 - 0.02 14.4 0.3 0.052 13.0 0.2 1.5 1 1 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap Pkinase PF00069.25 KOO20938.1 - 1.5e-42 145.8 0.4 7.3e-42 143.6 0.0 2.1 3 0 0 3 3 3 1 Protein kinase domain MFS_1 PF07690.16 KOO20938.1 - 9.6e-25 87.2 25.9 9.6e-25 87.2 25.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KOO20938.1 - 7.5e-18 64.1 1.1 2e-15 56.1 0.0 2.2 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Pkinase_Tyr PF07714.17 KOO20938.1 - 6.6e-16 58.4 0.0 1.1e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sugar_tr PF00083.24 KOO20938.1 - 4.7e-11 42.2 4.3 4.7e-11 42.2 4.3 3.0 2 1 0 2 2 2 1 Sugar (and other) transporter Kdo PF06293.14 KOO20938.1 - 0.13 11.6 0.3 0.23 10.8 0.3 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pterin_bind PF00809.22 KOO20939.1 - 6e-71 239.0 0.1 1e-44 153.1 0.0 2.2 2 0 0 2 2 2 2 Pterin binding enzyme HPPK PF01288.20 KOO20939.1 - 8e-35 119.7 0.0 1.5e-34 118.8 0.0 1.5 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.18 KOO20939.1 - 2.2e-20 73.3 0.0 4e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Dihydroneopterin aldolase TetR_C_35 PF18556.1 KOO20940.1 - 0.047 13.8 0.4 0.088 13.0 0.4 1.4 1 0 0 1 1 1 0 Bacterial Tetracyclin repressor, C-terminal domain Sec5 PF15469.6 KOO20941.1 - 5.3 6.8 8.1 2.8 7.7 5.7 1.7 1 1 0 1 1 1 0 Exocyst complex component Sec5 Glyco_hydro_65m PF03632.15 KOO20942.1 - 2.5e-49 168.1 0.0 5.4e-43 147.3 0.1 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain DUF2152 PF10222.9 KOO20942.1 - 8.8e-06 24.3 0.0 0.11 10.8 0.0 2.7 2 1 0 2 2 2 2 Uncharacterized conserved protein (DUF2152) Ank_2 PF12796.7 KOO20943.1 - 7.4e-26 90.6 6.9 2.9e-11 43.8 0.3 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO20943.1 - 2.1e-19 69.3 11.2 3.9e-07 30.2 0.0 4.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO20943.1 - 2.1e-19 69.6 2.6 2e-06 28.2 0.0 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) WD40 PF00400.32 KOO20943.1 - 2.2e-19 69.4 2.7 0.0016 19.2 0.0 6.6 5 1 1 6 6 6 5 WD domain, G-beta repeat Ank PF00023.30 KOO20943.1 - 1.9e-12 47.0 10.7 0.0006 20.2 0.6 6.1 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 KOO20943.1 - 4.4e-10 38.9 7.3 0.035 14.6 0.0 6.0 6 0 0 6 6 5 2 Ankyrin repeat LRR_6 PF13516.6 KOO20943.1 - 3.8e-08 32.8 1.8 4.1e-06 26.4 0.1 4.1 4 0 0 4 4 4 1 Leucine Rich repeat ANAPC4_WD40 PF12894.7 KOO20943.1 - 5e-07 29.9 0.0 0.15 12.4 0.0 4.4 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain LRR_4 PF12799.7 KOO20943.1 - 0.093 13.2 0.3 3.9 8.0 0.0 2.8 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) F-box PF00646.33 KOO20943.1 - 0.18 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 F-box domain LRR_8 PF13855.6 KOO20943.1 - 0.25 11.1 1.2 32 4.4 0.0 2.8 3 0 0 3 3 3 0 Leucine rich repeat Kinesin PF00225.23 KOO20944.1 - 1.2e-75 254.5 0.0 2.3e-75 253.6 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO20944.1 - 7.4e-29 100.6 0.0 6e-28 97.7 0.0 2.5 2 0 0 2 2 2 1 Microtubule binding Calpain_III PF01067.22 KOO20944.1 - 5.9e-09 36.3 0.0 1.8e-06 28.3 0.0 3.4 3 0 0 3 3 3 1 Calpain large subunit, domain III AAA_22 PF13401.6 KOO20944.1 - 0.023 15.0 0.0 0.12 12.7 0.0 2.2 1 0 0 1 1 1 0 AAA domain Arm PF00514.23 KOO20944.1 - 0.026 14.6 0.4 4.8 7.4 0.0 3.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Sec20 PF03908.13 KOO20944.1 - 0.088 12.7 1.9 0.2 11.6 0.4 2.5 2 0 0 2 2 2 0 Sec20 Atx10homo_assoc PF09759.9 KOO20944.1 - 0.24 11.5 1.7 17 5.5 0.0 3.9 3 1 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Fib_alpha PF08702.10 KOO20944.1 - 8.9 6.5 16.0 1.5 9.0 0.0 3.9 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family MFS_1 PF07690.16 KOO20945.1 - 0.011 14.7 3.0 0.016 14.2 3.0 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily EF-hand_1 PF00036.32 KOO20946.1 - 6.6e-13 47.2 0.1 4.2e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO20946.1 - 1.5e-11 43.3 0.1 5e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO20946.1 - 1.8e-10 41.1 0.1 3e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO20946.1 - 5.5e-09 35.1 0.2 0.0011 18.4 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO20946.1 - 0.00044 20.0 0.8 0.0092 15.8 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO20946.1 - 0.1 12.6 0.1 0.28 11.1 0.1 1.7 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand THOC7 PF05615.13 KOO20946.1 - 0.94 9.8 4.4 10 6.4 0.1 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 VKG_Carbox PF05090.14 KOO20947.1 - 0.023 13.5 1.6 0.033 13.0 1.6 1.2 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase Frigida PF07899.11 KOO20948.1 - 1.9e-05 24.1 0.0 0.0074 15.6 0.0 2.3 2 0 0 2 2 2 2 Frigida-like protein Pkinase PF00069.25 KOO20949.1 - 6.7e-24 84.7 0.0 1.3e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain U-box PF04564.15 KOO20949.1 - 1.8e-20 72.9 0.0 5.1e-19 68.2 0.0 2.6 2 0 0 2 2 2 1 U-box domain Pkinase_Tyr PF07714.17 KOO20949.1 - 1.1e-13 51.0 0.0 2.6e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO20949.1 - 0.0002 20.3 0.1 0.00099 18.0 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase zf-NOSIP PF15906.5 KOO20949.1 - 0.00043 20.4 0.0 0.0013 18.9 0.0 1.8 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein DnaJ PF00226.31 KOO20949.1 - 0.0025 17.9 0.0 0.0096 16.0 0.0 2.0 1 0 0 1 1 1 1 DnaJ domain zf-Nse PF11789.8 KOO20949.1 - 0.15 11.9 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit HR1 PF02185.16 KOO20949.1 - 2.3 8.4 4.6 5.1 7.3 0.1 3.4 3 0 0 3 3 3 0 Hr1 repeat Muted PF14942.6 KOO20949.1 - 4 7.8 11.9 2 8.7 0.0 4.0 3 1 1 4 4 4 0 Organelle biogenesis, Muted-like protein Prefoldin_2 PF01920.20 KOO20951.1 - 7.4e-21 74.1 0.2 8.6e-21 73.9 0.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit Tup_N PF08581.10 KOO20951.1 - 0.0012 19.1 1.9 0.019 15.2 0.5 2.1 2 0 0 2 2 2 1 Tup N-terminal RmuC PF02646.16 KOO20951.1 - 0.062 12.4 0.9 0.88 8.6 0.0 2.0 2 0 0 2 2 2 0 RmuC family Prefoldin PF02996.17 KOO20951.1 - 0.075 13.0 3.8 0.12 12.3 1.7 1.9 1 1 1 2 2 2 0 Prefoldin subunit TPR_10 PF13374.6 KOO20953.1 - 1.3e-66 218.9 41.0 8.7e-13 47.7 0.1 8.7 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.6 KOO20953.1 - 3.8e-54 180.9 39.6 1.1e-16 60.8 2.7 5.9 2 2 2 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOO20953.1 - 2.7e-17 61.5 16.6 0.0011 19.0 0.2 7.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO20953.1 - 2.9e-17 63.1 25.5 5.7e-11 42.4 2.1 4.0 2 1 1 3 3 3 2 MalT-like TPR region TPR_7 PF13176.6 KOO20953.1 - 4.9e-17 60.6 33.8 0.0012 18.8 0.1 8.5 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 KOO20953.1 - 1e-15 56.5 28.4 0.0062 16.6 0.2 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 KOO20953.1 - 4.5e-15 54.8 19.7 0.0008 19.1 0.1 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_4 PF07721.14 KOO20953.1 - 6.3e-13 48.0 27.7 0.07 13.8 0.5 9.1 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOO20953.1 - 6.9e-10 38.6 8.6 0.69 10.4 0.0 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat LRR_6 PF13516.6 KOO20953.1 - 2.3e-09 36.5 3.5 0.0021 18.0 0.0 3.6 3 0 0 3 3 3 2 Leucine Rich repeat TPR_16 PF13432.6 KOO20953.1 - 2e-08 34.7 51.5 1.4e-05 25.6 0.8 7.6 5 2 2 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO20953.1 - 1.8e-07 31.4 44.8 0.14 13.1 0.1 9.5 8 1 1 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO20953.1 - 0.00041 20.8 32.4 0.11 13.0 0.5 5.3 4 1 0 4 4 4 3 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO20953.1 - 0.062 13.6 0.2 64 3.9 0.0 4.0 4 0 0 4 4 3 0 Osmosensory transporter coiled coil MIT PF04212.18 KOO20953.1 - 0.21 11.7 4.6 8.6 6.5 0.1 4.9 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 KOO20953.1 - 0.29 10.8 20.3 7 6.4 0.2 7.0 7 1 1 8 8 8 0 TPR repeat TPR_21 PF09976.9 KOO20953.1 - 0.52 10.0 14.9 0.071 12.8 4.2 3.9 2 1 2 4 4 4 0 Tetratricopeptide repeat-like domain TPR_5 PF12688.7 KOO20953.1 - 2.8 8.2 29.3 0.2 11.9 2.3 6.2 3 2 3 6 6 6 0 Tetratrico peptide repeat PPR PF01535.20 KOO20953.1 - 5.8 7.4 5.8 1.4 9.3 0.1 3.1 5 0 0 5 5 3 0 PPR repeat Abhydrolase_6 PF12697.7 KOO20954.1 - 4.7e-12 47.0 4.2 5.6e-12 46.7 4.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO20954.1 - 2.1e-06 27.2 0.0 2.3e-05 23.8 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO20954.1 - 0.059 13.0 0.0 0.36 10.4 0.0 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 KOO20954.1 - 0.074 12.9 0.0 1.4 8.8 0.0 2.2 1 1 1 2 2 2 0 Serine hydrolase Abhydrolase_4 PF08386.10 KOO20954.1 - 0.087 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein DLH PF01738.18 KOO20954.1 - 0.18 11.3 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Synaptobrevin PF00957.21 KOO20955.1 - 1.1e-13 50.8 0.8 1.6e-13 50.2 0.8 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 KOO20955.1 - 3.2e-07 30.3 0.0 6e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain SoDot-IcmSS PF16848.5 KOO20955.1 - 0.023 14.7 1.3 0.042 13.8 1.3 1.3 1 0 0 1 1 1 0 Substrate of the Dot/Icm secretion system, putative Ribosomal_S6 PF01250.17 KOO20956.1 - 1.2e-18 67.1 0.0 1.5e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 IBN_N PF03810.19 KOO20957.1 - 5.3e-10 39.1 0.2 1.8e-09 37.3 0.2 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain CRM1_C PF08767.11 KOO20957.1 - 0.073 12.2 0.1 0.24 10.5 0.1 1.8 1 0 0 1 1 1 0 CRM1 C terminal Ank_2 PF12796.7 KOO20959.1 - 1.2e-14 54.6 4.4 8e-10 39.2 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO20959.1 - 1.2e-12 48.1 0.1 2.9e-08 34.1 0.0 3.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO20959.1 - 7.3e-12 45.3 2.4 4.7e-05 23.6 0.0 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO20959.1 - 2.4e-11 42.8 0.1 0.018 15.6 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 KOO20959.1 - 4.3e-09 36.4 1.6 0.00045 20.5 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat ATC_hydrolase PF14196.6 KOO20959.1 - 6.5 7.5 6.0 2.9 8.6 0.6 2.4 1 1 0 2 2 2 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase AAA_11 PF13086.6 KOO20960.1 - 3e-62 210.8 0.1 2.9e-32 112.5 0.2 2.2 1 1 1 2 2 2 2 AAA domain AAA_12 PF13087.6 KOO20960.1 - 3.6e-60 203.0 0.0 5.4e-60 202.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO20960.1 - 9.9e-11 41.7 0.0 8.3e-09 35.4 0.0 2.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO20960.1 - 3.5e-10 40.4 0.1 4.1e-09 36.9 0.1 2.5 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOO20960.1 - 8.6e-07 28.9 0.2 0.0045 16.8 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 KOO20960.1 - 0.0013 18.3 0.0 1.3 8.5 0.0 2.4 2 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 KOO20960.1 - 0.014 15.7 0.8 0.19 12.1 0.1 2.8 3 0 0 3 3 3 0 AAA ATPase domain DEAD PF00270.29 KOO20960.1 - 0.046 13.5 0.0 0.087 12.6 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 KOO20960.1 - 0.078 13.3 0.0 0.28 11.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KOO20960.1 - 0.12 11.7 0.1 0.24 10.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI 6PF2K PF01591.18 KOO20961.1 - 9.2e-31 106.9 0.1 9.2e-22 77.4 0.0 2.1 1 1 1 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOO20961.1 - 1.1e-19 70.9 1.5 3.3e-18 66.1 0.1 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) ANAPC2 PF08672.11 KOO20962.1 - 2.7e-22 79.0 0.1 7.4e-22 77.6 0.1 1.8 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 Cullin PF00888.22 KOO20962.1 - 2.8e-21 75.8 0.0 6.5e-21 74.6 0.0 1.5 2 0 0 2 2 2 1 Cullin family TilS PF09179.11 KOO20962.1 - 0.0036 17.8 3.5 0.081 13.4 0.0 4.2 4 1 0 5 5 5 1 TilS substrate binding domain MCD_N PF17408.2 KOO20962.1 - 0.011 15.9 0.7 0.54 10.4 0.2 3.5 3 0 0 3 3 3 0 Malonyl-CoA decarboxylase N-terminal domain FeoC PF09012.10 KOO20962.1 - 0.014 15.4 0.0 0.053 13.6 0.0 2.0 1 0 0 1 1 1 0 FeoC like transcriptional regulator AAA_lid_5 PF17865.1 KOO20962.1 - 0.065 13.3 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 Midasin AAA lid domain GRIM-19 PF06212.12 KOO20963.1 - 3.6e-26 91.7 0.5 1.5e-12 47.6 0.1 2.0 1 1 1 2 2 2 2 GRIM-19 protein YfdX PF10938.8 KOO20963.1 - 0.095 12.6 0.1 0.13 12.2 0.1 1.1 1 0 0 1 1 1 0 YfdX protein DUF2555 PF10742.9 KOO20963.1 - 0.13 12.0 0.1 0.24 11.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) Ribosomal_L13 PF00572.18 KOO20964.1 - 5e-48 162.5 0.0 6.3e-48 162.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 DUF2046 PF09755.9 KOO20965.1 - 0.024 13.9 4.4 0.13 11.4 2.5 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) Fez1 PF06818.15 KOO20965.1 - 0.056 13.9 2.6 5.2 7.5 0.7 2.3 2 0 0 2 2 2 0 Fez1 Gly-zipper_YMGG PF13441.6 KOO20965.1 - 0.17 11.7 10.2 0.81 9.5 9.8 2.2 1 1 1 2 2 2 0 YMGG-like Gly-zipper NBP1 PF08537.10 KOO20965.1 - 0.29 10.5 1.0 0.67 9.3 0.5 1.7 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 DUF641 PF04859.12 KOO20965.1 - 1.2 9.5 7.9 0.3 11.4 2.6 2.3 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF2203 PF09969.9 KOO20965.1 - 1.7 9.4 4.7 23 5.7 0.4 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Gly-zipper_Omp PF13488.6 KOO20965.1 - 2.4 8.2 10.0 1.5 8.8 1.2 2.5 2 0 0 2 2 2 0 Glycine zipper ATG16 PF08614.11 KOO20965.1 - 3.4 7.9 22.7 1.1 9.5 7.4 2.9 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 KOO20965.1 - 6.1 6.9 20.3 5.7 7.0 7.2 2.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Pro_isomerase PF00160.21 KOO20968.1 - 7.9e-30 104.2 0.0 1.8e-29 103.0 0.0 1.6 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FKBP_C PF00254.28 KOO20968.1 - 9.6e-11 41.9 0.0 2e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 KOO20968.1 - 6.8e-05 22.5 0.1 0.44 10.5 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO20968.1 - 0.0048 16.9 1.5 2.9 8.2 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat GP11 PF08677.10 KOO20968.1 - 0.032 13.7 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 GP11 baseplate wedge protein Fis1_TPR_C PF14853.6 KOO20968.1 - 0.05 13.7 0.1 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 KOO20968.1 - 0.055 13.8 2.1 0.26 11.6 1.1 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO20968.1 - 0.55 10.4 2.3 0.97 9.6 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO20968.1 - 0.89 9.8 5.0 0.18 12.0 0.9 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO20968.1 - 1.1 10.1 5.2 29 5.6 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TFIIS_C PF01096.18 KOO20969.1 - 5.3e-10 39.0 13.2 6.6e-09 35.5 4.9 3.3 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 KOO20969.1 - 2.5e-06 27.2 1.4 2.5e-06 27.2 1.4 2.9 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit GFA PF04828.14 KOO20969.1 - 0.00027 21.2 9.9 0.11 12.9 0.0 3.5 2 2 1 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 KOO20969.1 - 0.03 14.4 0.7 0.03 14.4 0.7 2.7 2 1 0 2 2 2 0 Double zinc ribbon TF_Zn_Ribbon PF08271.12 KOO20969.1 - 0.36 10.4 6.7 8.2 6.0 0.0 3.8 3 1 0 3 3 3 0 TFIIB zinc-binding Zn_Tnp_IS1595 PF12760.7 KOO20969.1 - 0.7 9.9 12.4 4.8 7.2 2.9 2.8 2 1 1 3 3 3 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 KOO20969.1 - 2.5 8.1 0.0 2.5 8.1 0.0 3.8 4 0 0 4 4 4 0 PhnA Zinc-Ribbon Nudix_N_2 PF14803.6 KOO20969.1 - 5.1 7.1 10.1 4.5 7.3 1.9 3.5 3 1 0 3 3 3 0 Nudix N-terminal Glyco_transf_8 PF01501.20 KOO20970.1 - 5.2e-11 42.6 0.0 6.3e-10 39.0 0.0 2.7 1 1 0 1 1 1 1 Glycosyl transferase family 8 Rubi_NSP_C PF12601.8 KOO20971.1 - 0.0015 18.5 0.1 0.074 13.2 0.0 2.3 2 0 0 2 2 2 1 Rubivirus non-structural protein Methyltransf_23 PF13489.6 KOO20971.1 - 0.0022 17.8 0.0 0.0075 16.1 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Sulfatase PF00884.23 KOO20972.1 - 2.5e-23 82.9 0.0 3.4e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 KOO20973.1 - 0.018 15.3 0.1 0.076 13.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) Sulfatase_C PF14707.6 KOO20973.1 - 0.046 14.4 0.0 0.061 14.1 0.0 1.2 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase Cbl_N PF02262.16 KOO20976.1 - 0.1 12.6 0.2 0.36 10.8 0.2 1.8 1 1 1 2 2 2 0 CBL proto-oncogene N-terminal domain 1 CLPTM1 PF05602.12 KOO20977.1 - 6.4e-48 163.8 0.0 8.4e-48 163.4 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) GTP-bdg_N PF13167.6 KOO20979.1 - 2.7e-28 98.5 0.1 6.1e-28 97.3 0.1 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal GTP-bdg_M PF16360.5 KOO20979.1 - 5.3e-22 78.2 1.4 8.6e-22 77.5 1.4 1.3 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.23 KOO20979.1 - 2.4e-20 72.7 0.1 6.1e-20 71.4 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOO20979.1 - 0.00012 22.2 0.1 0.012 15.7 0.0 2.3 2 0 0 2 2 2 1 Dynamin family cobW PF02492.19 KOO20979.1 - 0.00032 20.3 4.3 0.14 11.7 0.2 2.7 2 1 1 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 KOO20979.1 - 0.00041 19.9 0.1 0.3 10.6 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOO20979.1 - 0.00046 19.8 0.4 0.0017 17.9 0.4 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 KOO20979.1 - 0.00052 20.5 0.0 0.0013 19.2 0.0 1.7 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 KOO20979.1 - 0.00079 19.4 0.0 0.035 14.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KOO20979.1 - 0.0093 16.4 0.6 0.02 15.3 0.6 1.5 1 0 0 1 1 1 1 AAA ATPase domain Arf PF00025.21 KOO20979.1 - 0.013 15.0 0.1 3.6 7.0 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_23 PF13476.6 KOO20979.1 - 0.027 15.0 0.1 0.073 13.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain RRM_1 PF00076.22 KOO20981.1 - 6.1e-20 70.8 1.2 2.1e-08 33.9 0.0 5.1 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO20981.1 - 3.9e-08 33.0 0.0 0.1 12.4 0.0 3.2 3 0 0 3 3 3 3 Occluded RNA-recognition motif SH3_6 PF12913.7 KOO20981.1 - 0.054 13.1 0.0 7.2 6.3 0.0 2.6 2 0 0 2 2 2 0 SH3 domain (SH3b1 type) tRNA_anti-codon PF01336.25 KOO20981.1 - 0.12 12.4 0.1 2.8 8.0 0.1 2.4 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain CH_2 PF06294.11 KOO20982.1 - 0.0038 17.3 5.0 1.2 9.4 0.0 4.4 4 0 0 4 4 4 2 CH-like domain in sperm protein DUF4478 PF14793.6 KOO20982.1 - 0.062 13.2 0.0 21 5.0 0.0 4.0 3 0 0 3 3 3 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases EF-hand_8 PF13833.6 KOO20982.1 - 0.29 11.0 3.9 14 5.6 0.3 4.5 4 0 0 4 4 4 0 EF-hand domain pair 2OG-FeII_Oxy_3 PF13640.6 KOO20983.1 - 1.2e-13 51.8 0.0 5.9e-13 49.5 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO20983.1 - 0.024 15.1 0.0 0.043 14.3 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily HIT PF01230.23 KOO20984.1 - 5.9e-24 84.7 0.0 7.6e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 KOO20984.1 - 4.5e-17 62.6 0.0 5.5e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Glyco_hydro_42 PF02449.15 KOO20987.1 - 0.062 12.6 0.1 0.095 12.0 0.1 1.2 1 0 0 1 1 1 0 Beta-galactosidase DUF3638 PF12340.8 KOO20988.1 - 5.4e-22 78.2 0.0 1.3e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO20988.1 - 2.5e-13 49.1 0.2 5.9e-13 47.9 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) ART PF01129.18 KOO20988.1 - 5.8e-12 45.4 0.0 4.7e-11 42.4 0.0 2.2 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Thioredoxin PF00085.20 KOO20988.1 - 1.5e-09 37.7 0.1 3.3e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin Ank_2 PF12796.7 KOO20988.1 - 3.8e-07 30.6 0.0 0.00066 20.2 0.0 4.7 3 1 1 4 4 4 1 Ankyrin repeats (3 copies) EF-hand_6 PF13405.6 KOO20988.1 - 7.3e-06 25.5 0.2 0.0045 16.8 0.1 3.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 KOO20988.1 - 0.00019 21.8 2.2 0.002 18.6 0.1 3.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO20988.1 - 0.012 15.1 0.8 7.9 6.3 0.0 3.0 2 0 0 2 2 2 0 EF hand Ank_5 PF13857.6 KOO20988.1 - 0.027 14.8 0.0 8.1 6.9 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO20988.1 - 0.057 14.0 0.1 1.8 9.3 0.0 3.7 3 1 1 4 4 4 0 Ankyrin repeats (many copies) TTL PF03133.15 KOO20989.1 - 2e-53 181.5 0.0 3.1e-53 180.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family NAP PF00956.18 KOO20989.1 - 1.2e-15 57.4 0.0 3.5e-15 55.9 0.0 1.7 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) ATPgrasp_YheCD PF14398.6 KOO20989.1 - 0.0091 15.3 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 YheC/D like ATP-grasp Glyco_hydro_42 PF02449.15 KOO20989.1 - 0.02 14.2 0.3 0.035 13.4 0.3 1.3 1 0 0 1 1 1 0 Beta-galactosidase Glyco_transf_8 PF01501.20 KOO20990.1 - 8.8e-12 45.1 0.2 1.1e-10 41.5 0.2 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 KOO20990.1 - 0.0015 18.5 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Mannosyl_trans3 PF11051.8 KOO20990.1 - 0.067 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative Glyco_transf_8 PF01501.20 KOO20991.1 - 2.8e-09 36.9 0.4 8.9e-08 32.0 0.5 2.8 2 1 0 2 2 2 1 Glycosyl transferase family 8 Cellulase PF00150.18 KOO20992.1 - 2.2e-07 30.6 0.6 3.8e-07 29.8 0.6 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AP_endonuc_2 PF01261.24 KOO20992.1 - 9.6e-05 21.9 0.1 0.00052 19.5 0.0 2.2 3 0 0 3 3 3 1 Xylose isomerase-like TIM barrel MORN PF02493.20 KOO20993.1 - 1.3e-63 207.2 74.9 8.6e-08 31.6 1.3 10.8 11 0 0 11 11 11 10 MORN repeat DUF3048_C PF17479.2 KOO20993.1 - 0.003 17.9 28.6 0.7 10.3 0.6 6.2 1 1 6 7 7 7 5 Protein of unknown function (DUF3048) C-terminal domain DUF448 PF04296.13 KOO20993.1 - 0.35 10.7 5.5 25 4.8 0.2 4.3 2 1 2 4 4 4 0 Protein of unknown function (DUF448) EF-hand_7 PF13499.6 KOO20994.1 - 0.0052 17.2 0.0 2.3 8.8 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO20994.1 - 0.048 14.0 0.1 1.3 9.4 0.0 3.2 4 0 0 4 4 4 0 EF-hand domain EF-hand_6 PF13405.6 KOO20994.1 - 0.19 11.8 0.0 6.8 6.9 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain Pkinase PF00069.25 KOO20995.1 - 9.2e-31 107.2 0.0 1.2e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO20995.1 - 2.5e-20 72.9 0.0 3.6e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 KOO20995.1 - 0.011 15.4 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 KOO20995.1 - 0.048 13.6 0.1 0.076 12.9 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family EF-hand_1 PF00036.32 KOO20996.1 - 4.2e-09 35.3 1.4 5e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO20996.1 - 1.1e-08 34.4 2.0 0.00023 20.9 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO20996.1 - 1.2e-08 35.3 0.1 2.6e-08 34.2 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO20996.1 - 1.3e-05 24.5 2.2 0.038 13.5 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO20996.1 - 3.2e-05 23.7 0.0 6.2e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair TTL PF03133.15 KOO20997.1 - 6.1e-73 245.5 0.0 1e-72 244.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO20997.1 - 4.9e-05 22.7 0.0 0.29 10.4 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO20997.1 - 0.018 14.3 0.0 4.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Pkinase PF00069.25 KOO20998.1 - 1.3e-52 178.7 0.0 2.2e-52 178.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO20998.1 - 8e-30 104.0 0.0 1.4e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 KOO20998.1 - 1.4e-08 34.7 0.0 1.3e-07 31.5 0.0 2.2 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Pkinase_fungal PF17667.1 KOO20998.1 - 1.1e-06 27.7 0.0 1.7e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO20998.1 - 9.1e-05 21.9 0.0 0.00019 20.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO20998.1 - 0.0045 16.4 0.0 0.0074 15.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO20998.1 - 0.068 13.1 0.0 0.64 9.9 0.0 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family LMWPc PF01451.21 KOO20999.1 - 3.1e-15 56.8 0.0 4.3e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase MCPVI PF02993.14 KOO21001.1 - 0.25 11.1 4.2 0.34 10.7 4.2 1.1 1 0 0 1 1 1 0 Minor capsid protein VI EF-hand_1 PF00036.32 KOO21002.1 - 2e-18 64.5 2.5 3.9e-05 22.9 0.0 3.9 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO21002.1 - 1.3e-16 59.0 5.5 2.1e-05 24.0 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO21002.1 - 4.1e-16 59.2 3.6 8e-11 42.2 0.9 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO21002.1 - 5.1e-13 48.7 4.1 7.3e-08 32.1 0.5 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO21002.1 - 1.8e-09 36.6 3.8 0.017 14.6 0.2 3.8 3 0 0 3 3 3 3 EF hand EF-hand_10 PF14788.6 KOO21002.1 - 3.4e-06 26.8 1.5 0.00043 20.1 0.3 3.1 2 1 1 3 3 3 1 EF hand EF-hand_4 PF12763.7 KOO21002.1 - 0.0062 16.5 0.3 9.2 6.3 0.0 3.3 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand Atx10homo_assoc PF09759.9 KOO21002.1 - 0.0062 16.5 8.7 0.25 11.4 0.0 6.3 4 3 5 9 9 9 2 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 KOO21002.1 - 0.13 12.3 0.1 0.13 12.3 0.1 10.2 11 0 0 11 11 11 0 Armadillo/beta-catenin-like repeat zf_C2HC_14 PF18574.1 KOO21002.1 - 5.1 7.0 8.8 8.4 6.3 0.8 3.5 3 0 0 3 3 3 0 C2HC Zing finger domain DSBA PF01323.20 KOO21003.1 - 0.035 13.9 0.0 1.9 8.2 0.0 2.5 2 1 0 2 2 2 0 DSBA-like thioredoxin domain Dicistro_VP4 PF11492.8 KOO21003.1 - 0.13 12.2 0.0 4.4 7.3 0.0 2.4 2 0 0 2 2 2 0 Cricket paralysis virus, VP4 Kinesin PF00225.23 KOO21004.1 - 8.3e-119 396.4 0.0 1e-118 396.1 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO21004.1 - 3.2e-27 95.3 0.0 5.1e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding PIF1 PF05970.14 KOO21004.1 - 0.016 14.4 0.1 0.025 13.8 0.1 1.2 1 0 0 1 1 1 0 PIF1-like helicase DoxX PF07681.12 KOO21004.1 - 1.9 9.1 11.7 0.41 11.3 4.6 2.7 2 0 0 2 2 2 0 DoxX PCRF PF03462.18 KOO21005.1 - 7e-39 133.7 0.1 1.3e-38 132.9 0.1 1.4 1 0 0 1 1 1 1 PCRF domain RF-1 PF00472.20 KOO21005.1 - 4.5e-34 116.9 0.2 7.9e-34 116.1 0.2 1.4 1 0 0 1 1 1 1 RF-1 domain FKBP_C PF00254.28 KOO21005.1 - 4.5e-10 39.7 0.0 5.2e-09 36.3 0.0 2.3 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase Filamin PF00630.19 KOO21006.1 - 2.9e-38 130.8 0.3 2.1e-14 54.2 0.0 5.9 5 1 0 5 5 5 5 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO21006.1 - 1.3e-07 31.8 5.4 0.00072 19.8 0.6 4.4 4 1 0 4 4 4 3 Invasin, domain 3 YtkA PF13115.6 KOO21006.1 - 0.00072 20.1 1.2 7.1 7.3 0.0 5.2 5 0 0 5 5 5 2 YtkA-like IBN_N PF03810.19 KOO21008.1 - 1.8e-12 47.0 0.0 7.8e-12 44.9 0.0 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.10 KOO21008.1 - 2.1e-06 26.9 0.0 2.8e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Cse1 Xpo1 PF08389.12 KOO21008.1 - 0.0034 17.4 0.0 0.032 14.3 0.0 2.5 2 0 0 2 2 2 1 Exportin 1-like protein HEAT_EZ PF13513.6 KOO21008.1 - 0.13 12.8 8.9 0.9 10.1 0.1 5.3 5 1 1 6 6 6 0 HEAT-like repeat HEAT PF02985.22 KOO21008.1 - 0.42 11.0 3.2 3.6 8.1 0.0 4.5 4 0 0 4 4 4 0 HEAT repeat FliP PF00813.20 KOO21009.1 - 0.099 12.5 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 FliP family TFIID_30kDa PF03540.13 KOO21010.1 - 3.7e-05 23.6 0.0 5.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit ER_lumen_recept PF00810.18 KOO21013.1 - 3.7e-53 180.3 2.8 5.8e-53 179.7 2.8 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor Enkurin PF13864.6 KOO21014.1 - 4.6e-15 55.9 1.4 5.1e-15 55.7 0.1 1.7 2 0 0 2 2 2 1 Calmodulin-binding SPX PF03105.19 KOO21016.1 - 6.2e-09 36.2 0.6 2e-05 24.7 0.0 4.1 4 1 1 5 5 5 2 SPX domain Zn_clus PF00172.18 KOO21016.1 - 0.0043 17.1 12.4 0.0043 17.1 12.4 1.9 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.32 KOO21018.1 - 0.00033 21.4 6.2 2.9 8.9 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat Nup160 PF11715.8 KOO21018.1 - 0.05 12.3 0.0 0.068 11.8 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 DegT_DnrJ_EryC1 PF01041.17 KOO21019.1 - 2.1e-36 126.0 0.1 2.4e-36 125.8 0.1 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family BRCC36_C PF18110.1 KOO21019.1 - 0.041 14.0 0.1 0.08 13.1 0.1 1.4 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain zf-HC5HC2H_2 PF13832.6 KOO21020.1 - 0.0038 17.4 1.6 0.0038 17.4 1.6 2.1 2 0 0 2 2 2 1 PHD-zinc-finger like domain PHD PF00628.29 KOO21020.1 - 0.0086 15.9 8.1 0.0086 15.9 8.1 3.0 3 0 0 3 3 3 1 PHD-finger zf-HC5HC2H PF13771.6 KOO21020.1 - 0.015 15.6 4.1 0.015 15.6 4.1 2.1 2 0 0 2 2 2 0 PHD-like zinc-binding domain UPF0113_N PF17833.1 KOO21022.1 - 4.5e-27 94.4 0.1 7.8e-27 93.7 0.1 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 KOO21022.1 - 7.8e-23 80.5 0.0 1.2e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain Bestrophin PF01062.21 KOO21025.1 - 6.7e-25 88.1 1.4 1.2e-24 87.2 1.4 1.3 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel EF-hand_1 PF00036.32 KOO21025.1 - 3.6e-12 44.9 1.8 1.2e-06 27.7 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO21025.1 - 5.8e-12 44.5 0.4 2.8e-06 26.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO21025.1 - 4.9e-11 42.9 0.1 9.3e-11 42.0 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO21025.1 - 9e-10 38.3 0.1 2.3e-09 37.0 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO21025.1 - 3e-08 32.8 0.7 0.0049 16.3 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 KOO21025.1 - 0.00099 18.9 1.4 0.0033 17.2 0.2 2.2 1 1 1 2 2 2 2 EF hand LIM PF00412.22 KOO21026.1 - 4.8e-12 45.9 8.7 2.6e-08 33.9 3.7 2.4 2 0 0 2 2 2 2 LIM domain Prok-RING_1 PF14446.6 KOO21026.1 - 0.009 15.9 5.2 0.11 12.4 0.2 2.9 2 0 0 2 2 2 2 Prokaryotic RING finger family 1 zf-dskA_traR PF01258.17 KOO21026.1 - 1.5 8.8 10.8 0.42 10.6 0.3 3.5 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger VATC PF18716.1 KOO21026.1 - 2 8.3 7.1 47 3.9 0.0 3.4 2 1 1 3 3 3 0 Vms1-associating treble clef domain PNP_UDP_1 PF01048.20 KOO21027.1 - 2.2e-21 76.2 3.1 3.3e-21 75.6 3.1 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily ACBP PF00887.19 KOO21028.1 - 6.3e-17 61.6 0.1 1.2e-16 60.7 0.1 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein Choline_kinase PF01633.20 KOO21028.1 - 0.17 11.4 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase UvrD-helicase PF00580.21 KOO21029.1 - 3.5e-09 36.6 0.0 5.2e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 KOO21029.1 - 6.1e-06 26.0 0.0 0.034 14.0 0.0 2.9 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C PF13361.6 KOO21029.1 - 0.0001 21.9 0.0 0.00016 21.2 0.0 1.3 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 KOO21029.1 - 0.0085 15.9 0.0 0.59 9.8 0.0 2.9 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 KOO21029.1 - 0.015 15.6 0.0 0.029 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KOO21029.1 - 0.058 12.8 0.0 0.099 12.1 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein IFT57 PF10498.9 KOO21029.1 - 0.15 11.0 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 VDE PF07137.11 KOO21030.1 - 1.2e-75 254.2 0.3 1.5e-75 253.8 0.3 1.1 1 0 0 1 1 1 1 VDE lipocalin domain Peptidase_S10 PF00450.22 KOO21031.1 - 3.9e-85 286.8 0.0 4.8e-85 286.5 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF1765 PF08578.10 KOO21032.1 - 5e-20 72.2 1.1 8.7e-20 71.4 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) FPN1 PF06963.12 KOO21033.1 - 1.3e-44 152.4 12.4 3.3e-28 98.4 6.1 2.1 1 1 1 2 2 2 2 Ferroportin1 (FPN1) Chloroa_b-bind PF00504.21 KOO21034.1 - 1.1e-29 104.1 0.5 6e-29 101.6 0.5 2.1 1 1 0 1 1 1 1 Chlorophyll A-B binding protein TauD PF02668.16 KOO21036.1 - 6.4e-29 101.6 0.3 1e-28 100.9 0.3 1.4 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family NepR PF18557.1 KOO21036.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Anti-sigma factor NepR EF-hand_1 PF00036.32 KOO21037.1 - 1.9e-19 67.7 0.6 0.00036 19.9 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO21037.1 - 2.6e-17 61.2 0.1 0.0048 16.7 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO21037.1 - 1.3e-16 60.8 0.5 2.3e-06 28.0 0.1 4.5 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO21037.1 - 7.5e-13 47.3 2.0 0.0023 17.3 0.1 5.1 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO21037.1 - 6.3e-05 22.7 0.4 1.7 8.5 0.0 3.8 2 2 2 4 4 4 3 EF-hand domain pair DED PF01335.21 KOO21037.1 - 0.011 16.1 1.4 2.3 8.6 0.2 2.7 2 0 0 2 2 2 0 Death effector domain EF-hand_11 PF08976.11 KOO21037.1 - 0.014 16.2 0.0 0.067 14.1 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain Rotamase_2 PF13145.6 KOO21037.1 - 1.4 9.8 5.2 0.28 12.0 1.2 1.9 2 0 0 2 2 2 0 PPIC-type PPIASE domain Peptidase_M10 PF00413.24 KOO21038.1 - 0.00079 19.3 0.0 0.033 14.0 0.0 2.2 2 0 0 2 2 2 1 Matrixin Astacin PF01400.24 KOO21038.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.6 KOO21038.1 - 0.054 13.1 0.2 0.13 11.9 0.1 1.6 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_C1 PF00112.23 KOO21039.1 - 2.4e-39 135.7 8.3 3.6e-39 135.1 8.3 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Amidase PF01425.21 KOO21040.1 - 7.6e-82 275.7 0.0 1.1e-81 275.2 0.0 1.2 1 0 0 1 1 1 1 Amidase TPR_11 PF13414.6 KOO21041.1 - 8.7e-09 34.9 1.0 0.0018 17.9 0.0 2.8 1 1 2 3 3 3 2 TPR repeat TPR_2 PF07719.17 KOO21041.1 - 4.7e-08 32.5 0.5 0.00042 20.2 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21041.1 - 1.2e-07 31.2 0.1 1.4e-05 24.7 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO21041.1 - 1.6e-07 31.2 0.4 0.011 16.1 0.0 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO21041.1 - 6.4e-05 23.4 3.4 0.0033 18.1 0.5 3.8 2 1 2 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO21041.1 - 0.00011 22.3 2.0 0.00032 20.8 1.7 2.0 1 1 0 1 1 1 1 Tetratricopeptide repeat 2OG-FeII_Oxy_3 PF13640.6 KOO21041.1 - 0.00092 20.1 0.0 0.0015 19.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_8 PF13181.6 KOO21041.1 - 0.002 18.2 0.0 0.13 12.6 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21041.1 - 0.0054 17.0 0.4 0.031 14.6 0.4 2.2 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21041.1 - 0.01 16.4 2.7 0.01 16.4 2.7 3.0 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO21041.1 - 0.018 14.9 0.5 0.11 12.3 0.1 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21041.1 - 0.041 14.4 2.0 0.041 14.4 2.0 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21041.1 - 0.048 13.7 0.0 2.2 8.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF778 PF05608.12 KOO21042.1 - 1.5e-19 71.1 0.1 4.8e-13 49.9 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF778) DUF4796 PF16044.5 KOO21042.1 - 0.00084 19.0 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4796) Tctex-1 PF03645.13 KOO21044.1 - 8.3e-27 93.4 0.0 1e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family PG_binding_1 PF01471.18 KOO21045.1 - 1.1e-22 79.9 0.3 2.5e-07 30.8 0.0 3.7 3 0 0 3 3 3 3 Putative peptidoglycan binding domain Popeye PF04831.13 KOO21045.1 - 7.3e-18 65.1 0.0 1.2e-17 64.4 0.0 1.3 1 0 0 1 1 1 1 Popeye protein conserved region PG_binding_3 PF09374.10 KOO21045.1 - 1.6e-11 44.3 6.9 0.14 12.4 0.1 6.0 4 2 2 6 6 6 4 Predicted Peptidoglycan domain cNMP_binding PF00027.29 KOO21045.1 - 4.7e-06 26.6 1.1 8.6e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain 3Beta_HSD PF01073.19 KOO21046.1 - 1.9e-39 135.4 0.0 2.6e-39 134.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KOO21046.1 - 2.4e-27 96.0 0.0 3.4e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO21046.1 - 8.3e-17 61.6 0.0 1.2e-16 61.1 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KOO21046.1 - 3.5e-15 55.9 2.1 5.1e-13 48.8 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Polyketide_cyc2 PF10604.9 KOO21046.1 - 1e-11 45.3 0.6 2.4e-11 44.1 0.6 1.5 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport RmlD_sub_bind PF04321.17 KOO21046.1 - 4e-09 36.0 0.0 6.6e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polyketide_cyc PF03364.20 KOO21046.1 - 7.3e-08 32.7 0.1 1.4e-07 31.8 0.1 1.4 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport NAD_binding_10 PF13460.6 KOO21046.1 - 1.3e-05 25.2 0.0 2.5e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 KOO21046.1 - 2.1e-05 23.8 0.0 0.00018 20.8 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 KOO21046.1 - 0.0005 20.0 0.0 0.00091 19.2 0.0 1.4 1 0 0 1 1 1 1 KR domain AHSA1 PF08327.11 KOO21046.1 - 0.014 15.6 0.0 0.026 14.7 0.0 1.4 1 0 0 1 1 1 0 Activator of Hsp90 ATPase homolog 1-like protein Methyltransf_21 PF05050.12 KOO21047.1 - 6.5e-07 29.5 0.0 9.1e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain FKBP_C PF00254.28 KOO21048.1 - 5.6e-17 61.9 0.0 1.3e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 KOO21048.1 - 3.2e-08 34.4 0.5 9.2e-08 33.0 0.0 1.9 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase EF-hand_7 PF13499.6 KOO21049.1 - 9.8e-10 38.8 0.2 2.3e-09 37.6 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair Na_Ca_ex PF01699.24 KOO21049.1 - 4.4e-09 36.5 32.3 2.3e-05 24.4 15.8 3.0 2 2 0 2 2 2 2 Sodium/calcium exchanger protein EF-hand_6 PF13405.6 KOO21049.1 - 2.6e-08 33.2 1.3 0.00017 21.2 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO21049.1 - 2.7e-08 32.8 0.9 0.00047 19.5 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21049.1 - 4.3e-05 23.3 0.4 0.00012 21.8 0.2 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO21049.1 - 7.7e-05 22.0 0.0 0.53 9.9 0.0 2.5 2 0 0 2 2 2 2 EF hand CcmE PF03100.15 KOO21049.1 - 0.12 12.3 0.1 0.39 10.7 0.1 1.8 1 0 0 1 1 1 0 CcmE ZZ PF00569.17 KOO21050.1 - 3.4e-07 30.0 0.7 4.8e-07 29.5 0.7 1.2 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 KOO21050.1 - 0.047 14.0 0.5 0.069 13.5 0.5 1.3 1 0 0 1 1 1 0 C1 domain NAPRTase_N PF17767.1 KOO21051.1 - 0.056 13.8 0.4 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Choline_transpo PF04515.12 KOO21053.1 - 6.2e-59 199.8 37.6 6.2e-59 199.8 37.6 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter DUF2590 PF10761.9 KOO21054.1 - 0.086 13.0 0.9 0.24 11.6 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2590) Ribosomal_L12 PF00542.19 KOO21055.1 - 4.7e-11 42.9 8.3 4.7e-11 42.9 8.3 2.0 1 1 1 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 KOO21055.1 - 1.7e-08 34.1 1.8 1.7e-08 34.1 1.8 2.3 3 0 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain DUF2222 PF09984.9 KOO21055.1 - 0.099 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) DUF4777 PF16007.5 KOO21055.1 - 0.1 12.9 0.3 0.18 12.1 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4777) RCC1 PF00415.18 KOO21056.1 - 3.6e-21 75.5 4.7 2.4e-05 24.8 0.1 6.0 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO21056.1 - 3.8e-12 45.7 19.6 0.0011 18.8 2.5 5.9 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 KOO21056.1 - 2.1 8.8 96.8 0.044 14.2 8.9 7.3 7 1 0 7 7 7 0 EGF-like domain TIMELESS PF04821.14 KOO21057.1 - 4.6e-38 131.1 0.0 5.8e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 Timeless protein TIMELESS_C PF05029.13 KOO21058.1 - 4.1e-15 56.0 0.2 4.1e-15 56.0 0.2 3.6 3 1 0 4 4 4 1 Timeless protein C terminal region Myb_DNA-bind_6 PF13921.6 KOO21058.1 - 0.077 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain TIMELESS PF04821.14 KOO21058.1 - 0.18 11.0 0.0 0.39 9.9 0.0 1.6 2 0 0 2 2 2 0 Timeless protein DnaJ PF00226.31 KOO21059.1 - 7.4e-18 64.4 0.1 1.4e-17 63.5 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Ank_2 PF12796.7 KOO21059.1 - 1.1e-13 51.5 0.1 2.8e-13 50.3 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO21059.1 - 8.2e-13 48.3 0.8 1e-06 28.9 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO21059.1 - 5.3e-12 46.0 0.1 3.2e-08 34.0 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO21059.1 - 4.4e-11 42.7 1.7 0.0018 18.6 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO21059.1 - 1.7e-10 40.2 0.1 0.00023 21.4 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat TPR_2 PF07719.17 KOO21059.1 - 2.3e-10 39.8 4.5 0.014 15.5 0.1 4.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21059.1 - 2.5e-07 30.2 2.0 0.038 13.8 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21059.1 - 0.00042 20.5 0.7 0.00042 20.5 0.7 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21059.1 - 0.0017 18.4 0.1 0.77 10.1 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21059.1 - 0.0027 18.3 3.9 0.0027 18.3 3.9 6.6 6 1 0 6 6 4 1 Tetratricopeptide repeat HTH_37 PF13744.6 KOO21059.1 - 0.066 13.2 1.8 0.14 12.2 0.3 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain TPR_17 PF13431.6 KOO21060.1 - 2.3e-15 55.7 1.2 9e-05 22.6 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat 2OG-FeII_Oxy_3 PF13640.6 KOO21060.1 - 2.4e-13 50.8 0.0 4.8e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_1 PF00515.28 KOO21060.1 - 1.3e-12 46.9 6.5 0.00096 18.9 0.1 5.1 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21060.1 - 4.3e-12 45.5 9.3 1e-06 28.3 0.1 4.0 2 2 2 4 4 4 3 TPR repeat TPR_2 PF07719.17 KOO21060.1 - 1.6e-11 43.4 12.7 0.013 15.6 0.1 5.2 5 1 0 5 5 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21060.1 - 2e-08 34.7 14.2 7.5e-05 23.3 0.3 4.3 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21060.1 - 7.6e-07 29.6 9.7 0.0046 17.4 1.5 3.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21060.1 - 5.3e-05 23.4 12.5 0.025 14.9 5.1 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21060.1 - 0.00046 20.2 8.1 2.6 8.5 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO21060.1 - 0.00094 19.8 12.3 0.93 10.5 0.3 5.0 2 1 3 5 5 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO21060.1 - 0.064 13.1 8.9 15 5.6 0.1 4.8 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO21060.1 - 0.086 13.5 4.2 13 6.8 0.0 4.5 3 2 1 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21060.1 - 0.21 11.7 3.3 9.8 6.5 0.1 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 KOO21060.1 - 0.66 9.7 8.6 1.5 8.5 8.6 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain Peptidase_M16 PF00675.20 KOO21062.1 - 1e-53 181.3 0.3 1.6e-53 180.7 0.3 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOO21062.1 - 7.7e-29 101.0 0.0 7.7e-27 94.5 0.0 2.2 2 0 0 2 2 2 2 Peptidase M16 inactive domain M16C_assoc PF08367.11 KOO21062.1 - 0.015 14.4 0.1 0.028 13.6 0.1 1.4 1 0 0 1 1 1 0 Peptidase M16C associated V-SNARE_C PF12352.8 KOO21063.1 - 4.1e-14 52.6 0.6 4.1e-14 52.6 0.6 1.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 KOO21063.1 - 1.6e-11 44.4 3.6 3e-11 43.5 0.2 2.5 2 1 1 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 KOO21063.1 - 9.4e-05 22.3 0.1 0.00023 21.0 0.1 1.6 1 0 0 1 1 1 1 Sec20 DUF4407 PF14362.6 KOO21063.1 - 0.00062 19.2 1.9 0.00085 18.8 1.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Effector_1 PF04518.12 KOO21063.1 - 0.0036 16.5 0.0 0.0053 15.9 0.0 1.2 1 0 0 1 1 1 1 Effector from type III secretion system Pox_A_type_inc PF04508.12 KOO21063.1 - 0.02 14.7 0.1 0.052 13.4 0.1 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat TMF_TATA_bd PF12325.8 KOO21063.1 - 0.046 13.9 2.3 7.6 6.8 0.1 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Uso1_p115_C PF04871.13 KOO21063.1 - 0.049 14.0 2.6 0.56 10.6 0.3 2.3 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region GTP-bdg_M PF16360.5 KOO21063.1 - 0.055 14.1 0.5 0.055 14.1 0.5 2.2 2 1 0 2 2 2 0 GTP-binding GTPase Middle Region DUF5082 PF16888.5 KOO21063.1 - 0.11 12.8 0.3 0.38 11.0 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DivIC PF04977.15 KOO21063.1 - 0.11 12.3 1.3 0.17 11.7 0.1 1.9 2 0 0 2 2 2 0 Septum formation initiator TPR_MLP1_2 PF07926.12 KOO21063.1 - 0.14 12.2 6.6 1.3 9.1 1.5 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Tektin PF03148.14 KOO21063.1 - 0.17 10.6 2.1 0.3 9.8 0.0 2.0 2 0 0 2 2 2 0 Tektin family MscS_porin PF12795.7 KOO21063.1 - 0.34 10.4 6.7 1.3 8.5 1.6 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain SNARE PF05739.19 KOO21063.1 - 1.2 9.1 4.7 37 4.4 0.1 3.3 3 0 0 3 3 3 0 SNARE domain HR1 PF02185.16 KOO21063.1 - 6.2 7.0 8.2 0.39 10.9 1.7 2.3 2 2 0 2 2 2 0 Hr1 repeat PseudoU_synth_2 PF00849.22 KOO21064.1 - 3.9e-13 49.8 0.0 5.7e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 KOO21064.1 - 1e-08 34.7 0.4 3.1e-08 33.2 0.4 1.9 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 KOO21064.1 - 0.077 12.8 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 S4 domain ThiS PF02597.20 KOO21064.1 - 0.13 13.0 0.0 0.34 11.6 0.0 1.7 1 0 0 1 1 1 0 ThiS family Pkinase PF00069.25 KOO21066.1 - 1.7e-56 191.5 0.0 4.9e-38 131.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21066.1 - 1.7e-29 102.9 0.0 3.2e-24 85.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KOO21066.1 - 3e-05 24.1 0.2 0.012 15.5 0.1 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO21066.1 - 0.0011 18.0 0.0 0.0016 17.4 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain ABC1 PF03109.16 KOO21066.1 - 0.0038 17.4 0.0 0.3 11.2 0.0 2.4 2 0 0 2 2 2 1 ABC1 family RIO1 PF01163.22 KOO21066.1 - 0.0046 16.6 0.0 0.0089 15.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 KOO21066.1 - 0.019 14.3 0.3 3.6 6.8 0.0 2.8 3 0 0 3 3 3 0 Kinase-like LRR_6 PF13516.6 KOO21067.1 - 4e-19 67.0 1.1 0.00044 20.1 0.0 5.9 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.7 KOO21067.1 - 0.0011 19.4 0.0 4.2 7.9 0.0 3.6 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) TPR_2 PF07719.17 KOO21068.1 - 6.6e-06 25.9 2.3 0.0073 16.3 0.2 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO21068.1 - 0.00041 20.4 0.2 0.0011 19.1 0.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21068.1 - 0.069 13.0 5.3 1.3 9.0 0.4 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21068.1 - 0.09 13.0 0.8 9 6.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5113 PF17140.4 KOO21068.1 - 0.1 12.4 0.5 0.16 11.8 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) TPR_16 PF13432.6 KOO21068.1 - 1 10.1 8.4 0.12 13.1 2.6 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Aldo_ket_red PF00248.21 KOO21071.1 - 1.3e-13 50.9 0.0 1.5e-13 50.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TPR_1 PF00515.28 KOO21072.1 - 5.6e-18 63.9 0.0 1.4e-06 27.9 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21072.1 - 4.3e-14 51.4 0.6 1.5e-05 24.7 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21072.1 - 7.9e-06 26.1 0.4 0.0022 18.3 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO21072.1 - 4.3e-05 23.6 5.2 0.024 14.8 2.6 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21072.1 - 9.4e-05 22.0 0.5 0.03 14.0 0.0 3.5 2 2 1 3 3 3 1 TPR repeat TPR_14 PF13428.6 KOO21072.1 - 0.00016 22.2 6.0 0.59 11.1 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21072.1 - 0.00057 19.7 1.2 0.005 16.8 0.0 2.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21072.1 - 0.0074 16.9 7.4 1.2 9.9 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO21072.1 - 0.0077 16.5 0.2 2 9.0 0.1 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21072.1 - 0.0081 16.3 0.0 9.6 6.7 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO21072.1 - 0.016 14.5 0.9 0.64 9.2 1.0 2.3 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO21072.1 - 0.025 15.2 0.2 7.2 7.5 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Lant_dehydr_C PF14028.6 KOO21072.1 - 0.039 13.5 0.5 0.049 13.2 0.5 1.1 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term MIT PF04212.18 KOO21072.1 - 0.084 13.0 1.7 0.51 10.5 0.0 2.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain CAP_N PF01213.19 KOO21072.1 - 1.4 8.3 8.0 1.4 8.3 4.5 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal YabA PF06156.13 KOO21073.1 - 0.014 16.0 0.7 1.4 9.6 0.1 2.4 2 0 0 2 2 2 0 Initiation control protein YabA Dus PF01207.17 KOO21073.1 - 0.068 12.2 1.6 0.18 10.9 0.0 2.0 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) FlaC_arch PF05377.11 KOO21073.1 - 0.3 11.5 2.4 1.4 9.3 0.4 2.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) CCDC-167 PF15188.6 KOO21073.1 - 0.89 9.9 4.5 2.3 8.6 0.7 2.7 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 BLOC1_2 PF10046.9 KOO21073.1 - 1.4 9.3 7.2 12 6.2 0.8 3.0 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SlyX PF04102.12 KOO21073.1 - 7.8 7.2 10.5 12 6.6 0.4 2.9 3 0 0 3 3 3 0 SlyX ThrE PF06738.12 KOO21076.1 - 0.086 12.2 0.1 0.19 11.1 0.0 1.6 2 0 0 2 2 2 0 Putative threonine/serine exporter Seryl_tRNA_N PF02403.22 KOO21076.1 - 0.14 12.4 0.9 0.47 10.7 0.5 2.1 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FAST_1 PF06743.15 KOO21077.1 - 1.6e-06 28.0 0.0 0.0015 18.4 0.0 3.0 2 2 1 3 3 3 3 FAST kinase-like protein, subdomain 1 Peptidase_C1 PF00112.23 KOO21077.1 - 0.36 10.9 2.1 21 5.1 0.1 2.9 1 1 2 3 3 3 0 Papain family cysteine protease DUF3357 PF11837.8 KOO21078.1 - 0.049 14.1 0.5 0.08 13.4 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) CDT1_C PF16679.5 KOO21079.1 - 1.1e-06 29.0 0.3 1.9e-06 28.2 0.3 1.4 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain Ank_2 PF12796.7 KOO21080.1 - 3.2e-28 98.1 6.8 3.2e-17 62.9 2.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO21080.1 - 4.1e-23 81.1 12.2 1.6e-11 44.2 0.9 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO21080.1 - 5.2e-20 71.6 6.2 8.8e-12 45.3 0.5 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ACBP PF00887.19 KOO21080.1 - 7.3e-16 58.2 0.0 1.8e-15 56.9 0.0 1.6 2 0 0 2 2 2 1 Acyl CoA binding protein Ank_3 PF13606.6 KOO21080.1 - 2.2e-15 55.2 6.9 5.5e-05 23.2 0.1 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO21080.1 - 2.7e-15 56.0 11.2 9.9e-06 25.8 0.9 3.5 3 0 0 3 3 3 3 Ankyrin repeat UVR PF02151.19 KOO21082.1 - 1.4e-07 31.0 5.2 2.1e-07 30.4 5.2 1.3 1 0 0 1 1 1 1 UvrB/uvrC motif DUF4618 PF15397.6 KOO21082.1 - 0.0021 17.5 0.3 0.0026 17.2 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) HalX PF08663.10 KOO21082.1 - 0.015 15.6 2.5 1.1 9.7 1.0 2.2 1 1 1 2 2 2 0 HalX domain ABC_tran_CTD PF16326.5 KOO21082.1 - 0.027 14.7 7.8 0.046 14.0 7.8 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain HSCB_C PF07743.13 KOO21082.1 - 0.044 14.3 5.3 0.051 14.1 3.1 1.9 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain ADC PF06314.11 KOO21082.1 - 0.063 12.8 0.1 0.067 12.7 0.1 1.1 1 0 0 1 1 1 0 Acetoacetate decarboxylase (ADC) F420_oxidored PF03807.17 KOO21082.1 - 0.16 12.6 1.5 0.22 12.2 1.5 1.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PALP PF00291.25 KOO21083.1 - 3.1e-57 194.2 2.8 4.1e-57 193.9 2.8 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme YjeF_N PF03853.15 KOO21083.1 - 0.022 14.7 0.2 0.086 12.7 0.0 2.1 2 0 0 2 2 2 0 YjeF-related protein N-terminus APH PF01636.23 KOO21084.1 - 8.3e-08 32.4 0.1 1.4e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family LCM PF04072.14 KOO21085.1 - 3.2e-17 63.1 0.1 8.2e-11 42.2 0.1 2.2 1 1 1 2 2 2 2 Leucine carboxyl methyltransferase PP2C PF00481.21 KOO21086.1 - 1.4e-28 100.3 0.0 9.1e-28 97.6 0.0 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C MotY_N PF18393.1 KOO21086.1 - 0.0055 16.8 0.0 0.0091 16.1 0.0 1.3 1 0 0 1 1 1 1 MotY N-terminal domain SpoIIE PF07228.12 KOO21086.1 - 0.0084 16.0 0.1 0.033 14.1 0.0 1.8 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) Oxidored_FMN PF00724.20 KOO21088.1 - 1.5e-08 34.3 0.0 4.8e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family NMO PF03060.15 KOO21088.1 - 0.0073 15.7 3.8 0.0073 15.7 3.8 1.9 2 0 0 2 2 2 1 Nitronate monooxygenase Apolipoprotein PF01442.18 KOO21088.1 - 0.16 11.8 7.6 0.38 10.6 7.6 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain NAD_Gly3P_dh_C PF07479.14 KOO21089.1 - 3.6e-44 150.5 0.2 6.5e-44 149.7 0.2 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 KOO21089.1 - 2.5e-38 131.5 0.0 6.5e-38 130.2 0.0 1.7 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pro_isomerase PF00160.21 KOO21090.1 - 6.5e-45 153.2 0.0 8.4e-45 152.9 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPH PF13868.6 KOO21091.1 - 3e-64 216.8 126.5 3e-64 216.8 126.5 2.1 1 1 0 1 1 1 1 Trichohyalin-plectin-homology domain DnaJ_C PF01556.18 KOO21092.1 - 1.8e-24 86.5 0.0 2.5e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOO21092.1 - 2.6e-14 53.1 0.0 4.6e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain EF-hand_1 PF00036.32 KOO21093.1 - 1.5e-28 96.2 6.2 1.5e-07 30.5 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO21093.1 - 1e-24 86.8 1.8 6.6e-11 42.5 0.0 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO21093.1 - 1.5e-22 78.0 5.2 0.00011 21.5 0.4 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO21093.1 - 5.1e-20 69.6 0.3 0.0031 17.3 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO21093.1 - 4.2e-16 58.5 9.1 4e-07 29.8 0.2 4.3 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO21093.1 - 1.8e-08 34.5 0.7 0.00031 21.0 0.0 2.6 3 0 0 3 3 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO21093.1 - 1.7e-07 31.2 0.3 0.01 15.8 0.0 3.2 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO21093.1 - 2.3e-06 27.9 0.0 0.054 13.8 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO21093.1 - 8.2e-05 22.7 2.5 0.21 11.8 0.4 3.0 2 1 1 3 3 3 2 Dockerin type I domain p25-alpha PF05517.12 KOO21093.1 - 0.02 15.0 0.0 0.31 11.2 0.0 2.3 2 0 0 2 2 2 0 p25-alpha AP_endonuc_2_N PF07582.12 KOO21093.1 - 0.11 12.2 0.3 60 3.5 0.1 3.7 3 0 0 3 3 3 0 AP endonuclease family 2 C terminus EF-hand_10 PF14788.6 KOO21093.1 - 0.41 10.5 1.0 59 3.6 0.0 3.2 4 0 0 4 4 4 0 EF hand DUF4440 PF14534.6 KOO21093.1 - 4.2 7.8 5.5 12 6.3 0.8 3.3 2 2 0 2 2 2 0 Domain of unknown function (DUF4440) NHL PF01436.21 KOO21094.1 - 3.4e-42 140.4 8.1 2.1e-08 33.8 0.0 5.5 5 0 0 5 5 5 5 NHL repeat SGL PF08450.12 KOO21094.1 - 6.1e-20 71.9 13.3 0.00016 21.4 0.1 5.2 1 1 4 5 5 5 5 SMP-30/Gluconolactonase/LRE-like region BTB PF00651.31 KOO21094.1 - 1.1e-19 70.6 0.1 1.9e-19 69.9 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF839 PF05787.13 KOO21094.1 - 1.3e-12 47.7 5.3 0.013 14.7 0.1 4.7 1 1 4 5 5 5 4 Bacterial protein of unknown function (DUF839) Phytase-like PF13449.6 KOO21094.1 - 5.5e-07 29.8 0.1 0.064 13.2 0.0 4.0 1 1 3 4 4 4 2 Esterase-like activity of phytase Tcp10_C PF07202.13 KOO21094.1 - 0.0083 16.1 0.1 1.5 8.8 0.0 2.8 1 1 1 2 2 2 1 T-complex protein 10 C-terminus SBBP PF06739.11 KOO21094.1 - 0.013 15.5 5.0 15 5.7 0.0 4.9 5 0 0 5 5 5 0 Beta-propeller repeat SdiA-regulated PF06977.11 KOO21094.1 - 0.015 14.6 0.1 7.7 5.7 0.0 3.0 2 2 1 3 3 3 0 SdiA-regulated Ldl_recept_b PF00058.17 KOO21094.1 - 0.081 13.4 4.2 36 5.0 0.0 4.9 5 0 0 5 5 5 0 Low-density lipoprotein receptor repeat class B MGDG_synth PF06925.11 KOO21095.1 - 7.1e-15 55.5 0.0 1.4e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.16 KOO21095.1 - 1.5e-07 31.5 0.0 1.5e-07 31.5 0.0 3.0 3 1 0 3 3 3 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.6 KOO21095.1 - 1e-05 26.0 0.2 1e-05 26.0 0.2 3.0 3 0 0 3 3 3 1 Glycosyl transferases group 1 ARL2_Bind_BART PF11527.8 KOO21096.1 - 0.00017 21.7 0.3 0.0009 19.3 0.3 2.0 1 1 0 1 1 1 1 The ARF-like 2 binding protein BART Rossmann-like PF10727.9 KOO21096.1 - 0.02 14.8 0.1 0.23 11.3 0.0 2.6 2 1 0 2 2 2 0 Rossmann-like domain Ank_2 PF12796.7 KOO21097.1 - 9.8e-41 138.2 0.7 4.6e-14 52.8 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 KOO21097.1 - 1.1e-27 95.2 3.8 3.8e-05 23.9 0.1 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 KOO21097.1 - 3.5e-23 81.7 1.4 1.7e-07 31.7 0.0 5.3 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO21097.1 - 1.8e-22 79.1 2.2 3.7e-05 23.9 0.0 5.5 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO21097.1 - 1.6e-20 71.0 2.0 0.029 14.9 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat RRM_1 PF00076.22 KOO21098.1 - 5.1e-24 83.9 0.0 8.6e-08 31.9 0.0 5.4 4 2 2 6 6 6 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YqeY PF09424.10 KOO21098.1 - 0.12 12.5 0.1 0.32 11.1 0.0 1.7 2 0 0 2 2 2 0 Yqey-like protein RRM_7 PF16367.5 KOO21098.1 - 0.19 11.9 0.0 0.8 9.9 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif PilJ PF13675.6 KOO21098.1 - 0.68 10.0 3.9 1.6 8.7 1.2 2.7 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Ion_trans PF00520.31 KOO21099.1 - 1.8e-05 24.1 0.7 2.7e-05 23.5 0.7 1.2 1 0 0 1 1 1 1 Ion transport protein DUF2475 PF10629.9 KOO21102.1 - 0.0009 19.4 1.6 0.3 11.3 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) Mito_carr PF00153.27 KOO21103.1 - 9e-35 118.5 0.8 7.6e-16 57.8 0.0 3.0 1 1 2 3 3 3 3 Mitochondrial carrier protein Lys_export PF03956.13 KOO21103.1 - 0.045 13.3 0.1 0.081 12.5 0.1 1.4 1 0 0 1 1 1 0 Lysine exporter LysO MFS_1 PF07690.16 KOO21104.1 - 1.8e-27 96.2 52.4 5.7e-20 71.5 23.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Methyltransf_4 PF02390.17 KOO21104.1 - 1.2e-16 60.6 0.0 1.9e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Sugar_tr PF00083.24 KOO21104.1 - 0.0045 15.9 7.2 0.0045 15.9 7.2 2.6 1 1 0 2 2 2 2 Sugar (and other) transporter zf-TRM13_CCCH PF11722.8 KOO21104.1 - 0.05 13.4 1.3 0.084 12.7 1.3 1.4 1 0 0 1 1 1 0 CCCH zinc finger in TRM13 protein MFS_1_like PF12832.7 KOO21104.1 - 1.9 7.3 12.4 0.19 10.5 5.6 2.1 2 0 0 2 2 2 0 MFS_1 like family Sulfotransfer_4 PF17784.1 KOO21105.1 - 1.6e-24 87.0 0.2 4.6e-24 85.5 0.2 1.6 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KOO21105.1 - 0.0011 19.4 0.0 0.0015 19.0 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family T2SSM_b PF10741.9 KOO21106.1 - 0.078 12.8 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M subtype b BNR_2 PF13088.6 KOO21107.1 - 5.4e-50 170.2 0.5 6.6e-50 170.0 0.5 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 KOO21107.1 - 0.016 15.1 1.7 3 8.2 1.4 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat DUF3498 PF12004.8 KOO21107.1 - 0.23 10.6 0.1 0.54 9.4 0.0 1.4 1 1 0 2 2 2 0 Domain of unknown function (DUF3498) AAA PF00004.29 KOO21109.1 - 5.5e-54 182.1 0.1 6.9e-38 130.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO21109.1 - 8.2e-11 41.5 0.1 1.8e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 KOO21109.1 - 1.1e-09 38.0 0.1 0.0012 18.2 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 KOO21109.1 - 1.5e-09 38.3 0.9 0.0047 17.2 0.1 4.1 2 2 1 3 3 3 2 AAA domain AAA_5 PF07728.14 KOO21109.1 - 8e-09 35.6 0.2 5.6e-05 23.2 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) CDC48_N PF02359.18 KOO21109.1 - 1e-07 32.0 0.0 3.2e-07 30.4 0.0 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_16 PF13191.6 KOO21109.1 - 2.4e-07 31.3 0.3 0.019 15.4 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 KOO21109.1 - 3.8e-07 30.4 1.2 6.3e-05 23.2 0.4 2.9 2 2 1 3 3 3 1 AAA domain (Cdc48 subfamily) TsaE PF02367.17 KOO21109.1 - 1.8e-06 28.0 0.4 0.015 15.3 0.1 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 KOO21109.1 - 2.5e-06 27.3 0.1 0.021 14.6 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 KOO21109.1 - 7e-06 25.6 0.6 0.0055 16.1 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KOO21109.1 - 8e-06 26.4 0.0 0.092 13.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 KOO21109.1 - 2.1e-05 24.6 0.0 0.23 11.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 KOO21109.1 - 7.6e-05 22.5 0.1 0.52 10.0 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_33 PF13671.6 KOO21109.1 - 0.00015 22.0 0.0 0.71 10.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 KOO21109.1 - 0.00015 21.6 0.1 0.034 13.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KOO21109.1 - 0.00019 21.0 1.2 0.029 13.9 0.1 2.9 3 0 0 3 3 3 1 P-loop containing dynein motor region ATPase_2 PF01637.18 KOO21109.1 - 0.0002 21.4 3.9 7.7 6.3 0.1 4.2 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 KOO21109.1 - 0.00027 20.7 0.0 0.24 11.1 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein ResIII PF04851.15 KOO21109.1 - 0.00041 20.4 0.0 1.4 8.9 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit NACHT PF05729.12 KOO21109.1 - 0.00099 19.1 2.9 0.67 9.8 0.1 3.5 3 0 0 3 3 3 1 NACHT domain NB-ARC PF00931.22 KOO21109.1 - 0.0011 18.3 0.2 1.2 8.3 0.2 3.0 2 0 0 2 2 2 1 NB-ARC domain PhoH PF02562.16 KOO21109.1 - 0.0011 18.5 0.4 1.3 8.4 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein ABC_tran PF00005.27 KOO21109.1 - 0.0011 19.4 0.3 0.061 13.8 0.1 2.6 2 0 0 2 2 2 1 ABC transporter RNA_helicase PF00910.22 KOO21109.1 - 0.0012 19.2 0.0 0.16 12.4 0.0 2.6 2 0 0 2 2 2 1 RNA helicase ATPase PF06745.13 KOO21109.1 - 0.0013 18.1 1.8 0.028 13.8 0.1 3.1 2 1 0 3 3 3 1 KaiC DEAD PF00270.29 KOO21109.1 - 0.0019 18.0 3.3 2.2 8.0 0.0 4.1 2 2 2 4 4 4 1 DEAD/DEAH box helicase AAA_28 PF13521.6 KOO21109.1 - 0.0036 17.6 0.1 4.3 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 KOO21109.1 - 0.0041 17.0 0.0 0.22 11.4 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOO21109.1 - 0.0056 16.4 0.3 1.1 8.9 0.1 2.5 2 0 0 2 2 2 1 AAA domain CDC48_2 PF02933.17 KOO21109.1 - 0.0057 16.4 0.0 0.11 12.3 0.0 2.7 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 Rad17 PF03215.15 KOO21109.1 - 0.0058 16.6 0.7 9.8 6.1 0.1 3.8 3 2 1 4 4 4 0 Rad17 P-loop domain AAA_11 PF13086.6 KOO21109.1 - 0.0075 16.1 0.1 0.33 10.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 KOO21109.1 - 0.012 15.3 2.9 2.7 7.5 0.0 3.3 2 1 1 3 3 3 0 AAA domain T2SSE PF00437.20 KOO21109.1 - 0.02 13.9 0.0 2.5 7.1 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Parvo_NS1 PF01057.17 KOO21109.1 - 0.026 13.6 0.0 0.69 8.9 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 KOO21109.1 - 0.029 14.8 0.3 20 5.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain AFG1_ATPase PF03969.16 KOO21109.1 - 0.032 13.1 0.0 3.7 6.3 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase AAA_19 PF13245.6 KOO21109.1 - 0.046 14.1 1.3 0.81 10.0 0.2 3.1 3 0 0 3 3 3 0 AAA domain IPT PF01745.16 KOO21109.1 - 0.049 13.0 0.2 2 7.7 0.0 2.9 3 0 0 3 3 3 0 Isopentenyl transferase TniB PF05621.11 KOO21109.1 - 0.063 12.7 1.3 7.4 5.9 0.0 3.6 3 1 1 4 4 4 0 Bacterial TniB protein AAA_29 PF13555.6 KOO21109.1 - 0.078 12.7 0.1 14 5.5 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Cytidylate_kin PF02224.18 KOO21109.1 - 0.08 12.7 0.1 4.3 7.0 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase dNK PF01712.19 KOO21109.1 - 0.11 12.3 0.1 0.33 10.8 0.0 1.8 2 0 0 2 2 2 0 Deoxynucleoside kinase DUF2075 PF09848.9 KOO21109.1 - 0.2 10.8 1.6 2.1 7.5 0.1 2.7 2 2 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_21 PF13304.6 KOO21109.1 - 0.36 10.6 1.2 4.3 7.1 0.0 2.7 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system HIG_1_N PF04588.13 KOO21110.1 - 0.0019 18.4 0.9 0.005 17.0 0.0 2.1 2 0 0 2 2 2 1 Hypoxia induced protein conserved region ENOD93 PF03386.14 KOO21110.1 - 0.26 11.2 3.2 0.27 11.1 0.3 2.3 3 0 0 3 3 3 0 Early nodulin 93 ENOD93 protein CwsA PF10814.8 KOO21110.1 - 4.4 7.5 5.9 31 4.7 0.0 2.9 3 0 0 3 3 3 0 Cell wall synthesis protein CwsA Gemin6 PF06372.12 KOO21111.1 - 0.18 11.3 0.0 2.1 7.8 0.0 2.0 1 1 1 2 2 2 0 Gemin6 protein AA_permease_2 PF13520.6 KOO21116.1 - 2.8e-35 122.0 18.9 3.8e-35 121.5 18.9 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOO21116.1 - 8.1e-25 87.3 13.7 1.6e-23 83.1 13.7 2.0 1 1 0 1 1 1 1 Amino acid permease PEMT PF04191.13 KOO21117.1 - 1.4e-09 38.3 0.7 2e-09 37.8 0.7 1.3 1 1 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.14 KOO21117.1 - 9.6e-05 22.7 0.2 0.00016 22.0 0.2 1.3 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF1295 PF06966.12 KOO21117.1 - 0.044 13.3 0.1 0.056 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) PH PF00169.29 KOO21118.1 - 4.4e-10 40.0 0.0 5.7e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KOO21118.1 - 0.0004 20.6 0.8 0.014 15.6 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH_17 PF18012.1 KOO21118.1 - 0.021 14.5 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 PH domain PH_11 PF15413.6 KOO21118.1 - 0.037 14.4 3.3 1.1 9.8 1.6 2.2 1 1 1 2 2 2 0 Pleckstrin homology domain EF-hand_7 PF13499.6 KOO21119.1 - 3.6e-22 78.6 17.6 5e-08 33.3 0.3 3.2 1 1 4 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.6 KOO21119.1 - 3.5e-16 57.7 2.9 0.002 17.9 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO21119.1 - 3.6e-15 54.3 7.1 0.00074 18.9 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO21119.1 - 4.3e-13 48.1 4.2 0.00068 19.0 0.0 4.4 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.9 KOO21119.1 - 9e-11 42.1 0.7 0.004 17.5 0.1 3.3 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KOO21119.1 - 1.6e-09 37.4 3.3 0.0084 15.9 0.1 4.4 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_10 PF14788.6 KOO21119.1 - 0.00042 20.1 0.9 5.7 6.9 0.0 4.0 4 0 0 4 4 4 1 EF hand Caleosin PF05042.13 KOO21119.1 - 0.12 12.3 0.3 14 5.5 0.0 3.1 2 1 1 3 3 3 0 Caleosin related protein Excalibur PF05901.11 KOO21119.1 - 1.2 9.8 5.3 4.1 8.1 0.3 3.3 3 0 0 3 3 3 0 Excalibur calcium-binding domain MSC PF09402.10 KOO21119.1 - 1.8 8.0 3.1 5.6 6.3 3.1 1.7 1 1 0 1 1 1 0 Man1-Src1p-C-terminal domain Arm PF00514.23 KOO21120.1 - 0.0006 19.8 14.4 0.45 10.6 0.2 5.8 4 2 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KOO21120.1 - 0.0028 17.8 3.0 0.08 13.2 0.2 3.9 3 0 0 3 3 3 1 HEAT repeat RTP1_C1 PF10363.9 KOO21120.1 - 0.02 15.1 0.1 5.6 7.2 0.0 3.4 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 KOO21120.1 - 0.16 12.0 0.0 0.81 9.7 0.0 2.2 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KOO21120.1 - 0.23 12.0 3.9 15 6.2 0.0 4.2 4 0 0 4 4 4 0 HEAT-like repeat DUF3017 PF11222.8 KOO21120.1 - 2 8.7 7.3 17 5.8 5.4 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3017) HEAT_2 PF13646.6 KOO21120.1 - 2.8 8.4 8.7 7.7 7.0 0.2 3.8 2 2 3 5 5 5 0 HEAT repeats Trm56 PF01994.16 KOO21121.1 - 0.13 12.2 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 tRNA ribose 2'-O-methyltransferase, aTrm56 EF-hand_1 PF00036.32 KOO21122.1 - 1.3e-12 46.3 0.0 1.9e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO21122.1 - 3.4e-12 46.6 0.0 5.9e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO21122.1 - 3.8e-11 42.7 0.0 7.2e-10 38.6 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21122.1 - 4.8e-09 35.4 0.0 0.0017 18.1 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KOO21122.1 - 1.4e-07 30.6 0.0 0.0017 17.7 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 KOO21122.1 - 1.7e-05 25.0 0.0 2.8e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain DUF5580 PF17743.1 KOO21122.1 - 0.00011 20.9 0.0 0.00015 20.5 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) Frankia_peptide PF14407.6 KOO21122.1 - 0.00077 19.4 0.4 0.0047 16.9 0.0 2.2 2 0 0 2 2 2 1 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. EF-hand_4 PF12763.7 KOO21122.1 - 0.015 15.2 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 KOO21122.1 - 0.042 14.7 0.0 0.062 14.2 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO21122.1 - 0.052 13.9 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1456 PF07308.13 KOO21122.1 - 0.079 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) Arm PF00514.23 KOO21123.1 - 0.0087 16.1 0.5 0.56 10.3 0.3 3.1 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat PRKCSH PF07915.13 KOO21124.1 - 7.2e-06 26.9 7.8 0.007 17.4 0.2 2.8 2 1 0 2 2 2 2 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 KOO21124.1 - 0.0034 17.1 0.1 0.011 15.4 0.1 1.8 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Arm PF00514.23 KOO21125.1 - 8.8e-10 38.3 3.4 5.7e-06 26.2 0.2 3.9 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat EF-hand_7 PF13499.6 KOO21125.1 - 1.1e-08 35.4 0.1 2.7e-08 34.2 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO21125.1 - 1.9e-07 30.1 0.1 0.0066 15.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO21125.1 - 4.7e-06 26.1 0.1 0.0047 16.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO21125.1 - 9.5e-05 22.2 0.6 0.17 11.8 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO21125.1 - 0.00015 21.1 0.1 0.052 13.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO21125.1 - 0.0057 16.9 0.1 0.011 16.1 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO21125.1 - 0.0068 16.7 0.4 0.012 15.9 0.4 1.3 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region HEAT_EZ PF13513.6 KOO21125.1 - 0.065 13.8 3.4 4.1 8.0 1.1 3.7 3 1 0 3 3 3 0 HEAT-like repeat Imm48 PF15574.6 KOO21125.1 - 0.09 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Immunity protein 48 EF-hand_1 PF00036.32 KOO21127.1 - 5.6e-22 75.6 2.7 2.4e-06 26.7 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO21127.1 - 1.4e-19 70.3 2.8 4.1e-09 36.8 0.5 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21127.1 - 7.8e-19 65.9 1.4 0.00032 20.4 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain DUF4062 PF13271.6 KOO21127.1 - 2.5e-12 47.0 0.0 1.7e-11 44.3 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) EF-hand_5 PF13202.6 KOO21127.1 - 7.1e-12 44.3 2.0 0.00018 20.8 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO21127.1 - 7.4e-10 38.5 3.9 8.4e-06 25.5 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO21127.1 - 2.5e-08 34.2 0.2 0.0017 18.6 0.0 2.7 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region TPR_12 PF13424.6 KOO21127.1 - 1e-06 29.0 0.4 6.8e-05 23.1 0.1 3.9 5 0 0 5 5 4 2 Tetratricopeptide repeat EF-hand_10 PF14788.6 KOO21127.1 - 3e-06 27.0 5.4 0.0011 18.8 0.4 3.0 3 0 0 3 3 3 2 EF hand AAA_22 PF13401.6 KOO21127.1 - 1.2e-05 25.6 0.0 4.1e-05 23.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KOO21127.1 - 0.0001 22.2 0.0 0.00023 21.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 KOO21127.1 - 0.00048 20.5 0.0 0.0019 18.6 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 KOO21127.1 - 0.0034 16.9 0.0 0.0065 16.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region TPR_8 PF13181.6 KOO21127.1 - 0.11 12.8 1.0 43 4.7 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat EF-hand_9 PF14658.6 KOO21127.1 - 0.14 12.5 0.2 4.1 7.8 0.0 2.9 2 1 1 3 3 3 0 EF-hand domain LZ_Tnp_IS66 PF13007.7 KOO21127.1 - 0.85 10.4 0.0 0.85 10.4 0.0 3.4 3 1 0 3 3 2 0 Transposase C of IS166 homeodomain CCDC53 PF10152.9 KOO21127.1 - 2.6 8.4 4.2 1.4 9.3 1.3 2.0 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Proteasome PF00227.26 KOO21128.1 - 1.5e-18 67.0 0.8 4.7e-18 65.3 0.8 1.6 1 1 0 1 1 1 1 Proteasome subunit T2SSK PF03934.13 KOO21130.1 - 0.067 12.6 0.0 0.087 12.2 0.0 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K Myb_DNA-binding PF00249.31 KOO21131.1 - 5.8e-14 52.0 0.0 1.3e-11 44.5 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO21131.1 - 0.0004 20.2 0.1 0.49 10.3 0.0 2.5 2 0 0 2 2 2 2 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 KOO21131.1 - 0.00045 20.4 0.1 0.00094 19.4 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain RuvA_C PF07499.13 KOO21131.1 - 0.015 15.7 0.0 0.03 14.8 0.0 1.4 1 0 0 1 1 1 0 RuvA, C-terminal domain ZnuA PF01297.17 KOO21131.1 - 0.035 13.5 0.1 0.051 13.0 0.1 1.1 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Bacteriocin_IIc PF10439.9 KOO21131.1 - 0.13 12.4 0.1 0.13 12.4 0.1 1.6 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Trypsin_2 PF13365.6 KOO21132.1 - 5.5e-32 111.7 0.7 1e-31 110.8 0.7 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 KOO21132.1 - 9.4e-16 58.3 0.0 2e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 KOO21132.1 - 3.1e-12 46.6 0.1 8.1e-12 45.3 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO21132.1 - 0.00062 19.6 0.6 0.015 15.1 0.2 2.8 1 1 1 2 2 2 1 PDZ domain Peptidase_S29 PF02907.15 KOO21132.1 - 0.029 14.1 0.1 0.088 12.6 0.0 1.8 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease Peptidase_S32 PF05579.13 KOO21132.1 - 0.037 13.2 1.4 0.98 8.6 0.1 2.2 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 PDZ PF00595.24 KOO21132.1 - 0.13 12.7 0.2 1.5 9.2 0.2 2.6 1 1 0 1 1 1 0 PDZ domain Peptidase_S46 PF10459.9 KOO21132.1 - 0.14 10.8 1.3 1.3 7.6 0.5 2.2 2 0 0 2 2 2 0 Peptidase S46 Mito_carr PF00153.27 KOO21133.1 - 1.5e-50 169.1 4.7 1.1e-19 70.2 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 KOO21133.1 - 1.1e-20 71.6 2.1 2.6e-06 26.6 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 KOO21133.1 - 3.6e-19 67.3 3.4 5.9e-06 25.5 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO21133.1 - 6.3e-18 65.0 4.2 1.4e-10 41.5 0.3 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO21133.1 - 1.5e-17 63.2 1.9 1.5e-09 37.5 0.3 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO21133.1 - 1.2e-16 59.1 5.7 9.6e-06 25.1 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO21133.1 - 0.0027 18.0 0.0 0.02 15.2 0.0 2.0 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO21133.1 - 0.022 14.7 0.1 0.51 10.3 0.0 2.3 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO21133.1 - 0.05 13.9 0.1 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 EF-hand domain zf-C2H2_jaz PF12171.8 KOO21134.1 - 0.25 11.7 1.5 0.41 11.0 1.5 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOO21134.1 - 0.89 10.0 2.4 1.6 9.3 2.4 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Stm1_N PF09598.10 KOO21134.1 - 1.1 10.1 8.4 2.4 9.1 4.2 2.6 2 0 0 2 2 2 0 Stm1 MIF4G PF02854.19 KOO21135.1 - 2.6e-07 30.5 0.0 4e-07 29.9 0.0 1.4 2 0 0 2 2 2 1 MIF4G domain EF-hand_7 PF13499.6 KOO21136.1 - 0.0003 21.2 0.5 0.02 15.3 0.1 2.7 2 1 2 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21136.1 - 0.0008 19.1 0.1 0.0062 16.4 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO21136.1 - 0.0062 16.0 0.0 0.037 13.6 0.0 2.3 2 0 0 2 2 2 1 EF hand Filamin PF00630.19 KOO21137.1 - 5.4e-10 40.0 0.0 0.00062 20.6 0.0 3.5 4 0 0 4 4 4 2 Filamin/ABP280 repeat Uso1_p115_C PF04871.13 KOO21137.1 - 1.7 9.0 8.9 3 8.2 8.9 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region FAM199X PF15814.5 KOO21137.1 - 2.9 6.9 8.9 4.4 6.3 8.9 1.2 1 0 0 1 1 1 0 Protein family FAM199X DUF563 PF04577.14 KOO21138.1 - 8.3e-16 58.8 0.2 1.3e-15 58.1 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF563) GlutR_N PF05201.15 KOO21138.1 - 0.12 12.2 0.3 0.5 10.1 0.0 2.3 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, N-terminal domain Glycos_transf_1 PF00534.20 KOO21139.1 - 0.015 14.9 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferases group 1 TRAP_alpha PF03896.16 KOO21140.1 - 5.2e-06 25.9 0.0 6.4e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Mg_trans_NIPA PF05653.14 KOO21141.1 - 2.5e-111 371.5 17.1 3e-111 371.2 17.1 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KOO21141.1 - 0.00023 21.3 7.1 0.00023 21.3 7.1 4.2 3 1 1 4 4 4 2 EamA-like transporter family CNOT1_TTP_bind PF16417.5 KOO21141.1 - 0.061 12.5 0.2 0.091 11.9 0.2 1.2 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3671 PF12420.8 KOO21141.1 - 6.5 6.9 8.0 2.1 8.4 2.1 2.4 2 0 0 2 2 2 0 Protein of unknown function Rif1_N PF12231.8 KOO21142.1 - 0.0015 17.6 0.0 0.0064 15.5 0.0 1.8 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal Pkinase PF00069.25 KOO21144.1 - 9e-57 192.4 0.0 1.4e-56 191.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21144.1 - 7.1e-36 123.8 0.0 1.2e-35 123.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO21144.1 - 0.001 18.5 0.0 0.0065 15.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO21144.1 - 0.0049 15.7 0.0 0.074 11.8 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Mito_fiss_reg PF05308.11 KOO21144.1 - 0.12 12.5 3.5 0.1 12.7 1.6 1.8 2 0 0 2 2 2 0 Mitochondrial fission regulator DUF4715 PF15835.5 KOO21144.1 - 1.2 9.2 3.2 0.47 10.5 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4715) CAP_N PF01213.19 KOO21144.1 - 4.1 6.8 8.2 0.18 11.3 2.4 1.5 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal OB_NTP_bind PF07717.16 KOO21145.1 - 5.4e-24 84.4 0.0 1e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 KOO21145.1 - 8.1e-23 80.8 0.0 1.9e-22 79.6 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 KOO21145.1 - 7.1e-06 25.9 0.2 2.1e-05 24.4 0.2 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase S1 PF00575.23 KOO21145.1 - 8.4e-06 26.0 0.0 1.6e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain AAA_22 PF13401.6 KOO21145.1 - 2.4e-05 24.6 0.1 5.4e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO21145.1 - 0.00027 20.7 0.0 0.00052 19.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO21145.1 - 0.00064 20.1 0.2 0.0016 18.8 0.2 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KOO21145.1 - 0.0086 15.2 0.1 0.017 14.2 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.6 KOO21145.1 - 0.037 14.1 0.1 0.33 11.0 0.1 2.3 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO21145.1 - 0.037 13.3 0.0 0.058 12.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.14 KOO21145.1 - 0.04 13.9 0.1 0.077 13.0 0.1 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain PhoH PF02562.16 KOO21145.1 - 0.045 13.2 0.2 0.11 12.0 0.2 1.6 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 KOO21145.1 - 0.049 14.1 0.4 0.87 10.1 0.2 2.6 1 1 0 2 2 2 0 ABC transporter Microtub_bd PF16796.5 KOO21145.1 - 0.054 13.4 0.2 1.2 9.1 0.1 2.4 2 0 0 2 2 2 0 Microtubule binding Sigma54_activ_2 PF14532.6 KOO21145.1 - 0.072 13.2 0.1 0.35 11.0 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain DAP3 PF10236.9 KOO21145.1 - 0.085 12.0 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 SRP54 PF00448.22 KOO21145.1 - 0.091 12.4 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 KOO21145.1 - 0.16 11.5 0.1 0.32 10.5 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region UvrD-helicase PF00580.21 KOO21145.1 - 0.17 11.3 0.1 0.31 10.5 0.1 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain SATase_N PF06426.14 KOO21146.1 - 7.2e-14 52.0 0.2 6.2e-13 49.0 0.2 2.2 1 1 0 1 1 1 1 Serine acetyltransferase, N-terminal Hexapep PF00132.24 KOO21146.1 - 1.6e-09 37.1 10.2 3.2e-05 23.5 1.6 2.8 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KOO21146.1 - 8.6e-08 31.8 9.4 0.0016 18.2 4.0 3.4 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase DBI_PRT PF02277.17 KOO21147.1 - 8.4e-77 258.6 10.1 1e-76 258.3 10.1 1.0 1 0 0 1 1 1 1 Phosphoribosyltransferase DUF5429 PF17494.2 KOO21147.1 - 0.081 13.0 2.5 0.11 12.6 0.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5429) TTL PF03133.15 KOO21148.1 - 5.5e-25 88.1 0.0 7.7e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family EF-hand_1 PF00036.32 KOO21149.1 - 1.6e-33 111.7 11.0 4.3e-09 35.3 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO21149.1 - 9.3e-30 102.9 8.5 1.5e-16 60.6 0.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21149.1 - 9.7e-26 87.5 9.6 2.5e-09 36.3 0.0 4.9 4 2 2 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 KOO21149.1 - 1.1e-25 89.2 11.0 5.3e-12 45.4 0.3 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO21149.1 - 3.5e-20 70.5 8.5 2e-06 27.0 0.2 4.8 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.6 KOO21149.1 - 5.6e-14 52.2 0.2 7.6e-08 32.6 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO21149.1 - 2.5e-06 27.4 4.0 0.19 11.7 0.8 3.6 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand SurA_N_3 PF13624.6 KOO21149.1 - 0.00011 22.0 0.8 0.4 10.4 0.1 2.1 1 1 0 2 2 2 2 SurA N-terminal domain Caleosin PF05042.13 KOO21149.1 - 0.00041 20.3 1.0 3.5 7.5 0.0 3.7 1 1 3 4 4 4 1 Caleosin related protein SurA_N_2 PF13623.6 KOO21149.1 - 0.0008 19.3 0.7 0.73 9.7 0.0 2.3 1 1 1 2 2 2 2 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KOO21149.1 - 0.002 18.4 0.4 1.2 9.4 0.2 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO21149.1 - 0.0037 17.6 0.7 1.5 9.2 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain SUB1_ProdP9 PF18213.1 KOO21149.1 - 0.011 15.5 1.3 0.024 14.5 0.4 1.9 1 1 1 2 2 2 0 SUB1 protease Prodomain ProdP9 DUF3008 PF11450.8 KOO21149.1 - 0.018 15.2 4.8 0.023 14.8 0.2 3.0 4 0 0 4 4 4 0 Protein of unknwon function (DUF3008) LETM1 PF07766.13 KOO21149.1 - 0.042 13.2 0.8 0.13 11.6 0.7 1.9 1 1 1 2 2 2 0 LETM1-like protein YolD PF08863.10 KOO21149.1 - 0.067 13.2 1.7 3.1 7.9 0.1 2.8 3 1 0 3 3 3 0 YolD-like protein Peptidase_M24 PF00557.24 KOO21149.1 - 0.079 12.6 0.2 1.7 8.3 0.0 2.4 2 1 1 3 3 3 0 Metallopeptidase family M24 PMBR PF09373.10 KOO21149.1 - 0.1 12.8 0.2 22 5.4 0.0 4.4 6 0 0 6 6 6 0 Pseudomurein-binding repeat Acetyltransf_11 PF13720.6 KOO21149.1 - 0.13 12.8 0.4 1.1 9.8 0.1 2.4 1 1 1 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF3911 PF13050.6 KOO21149.1 - 0.16 12.1 1.5 0.6 10.3 0.5 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3911) SapB_1 PF05184.15 KOO21149.1 - 1.1 9.3 5.9 3.2 7.9 0.2 2.7 3 0 0 3 3 2 0 Saposin-like type B, region 1 RRM_1 PF00076.22 KOO21150.1 - 4.4e-21 74.5 0.0 3.8e-07 29.8 0.0 4.5 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SBDS PF01172.18 KOO21151.1 - 1.8e-25 88.8 0.8 2.8e-25 88.2 0.4 1.5 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 KOO21151.1 - 5.6e-24 84.4 0.0 8.8e-24 83.8 0.0 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain Sel1 PF08238.12 KOO21151.1 - 4.5e-05 24.0 0.0 8.8e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Sel1 repeat DUF4170 PF13773.6 KOO21151.1 - 0.15 12.3 0.4 9.2 6.5 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4170) DAO PF01266.24 KOO21152.1 - 3.2e-28 99.3 5.4 2.9e-27 96.2 5.4 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOO21152.1 - 2.2e-07 31.0 0.1 9.8e-07 28.9 0.1 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO21152.1 - 6e-07 28.9 6.1 1.6e-05 24.2 6.1 2.3 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 KOO21152.1 - 1.2e-05 24.7 0.1 2.4e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO21152.1 - 2.9e-05 24.5 0.0 0.00014 22.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO21152.1 - 6.8e-05 22.3 0.1 0.00012 21.4 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 KOO21152.1 - 0.0011 18.5 0.3 0.0028 17.1 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 KOO21152.1 - 0.0013 18.0 0.2 0.0071 15.6 0.1 1.9 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 KOO21152.1 - 0.0015 17.8 0.1 0.0015 17.8 0.1 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 KOO21152.1 - 0.0055 17.0 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain XdhC_C PF13478.6 KOO21152.1 - 0.01 16.3 0.0 0.023 15.2 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain HI0933_like PF03486.14 KOO21152.1 - 0.012 14.3 0.1 0.018 13.7 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 KOO21152.1 - 0.016 14.3 0.1 0.038 13.0 0.0 1.7 1 1 0 1 1 1 0 Lycopene cyclase protein GIDA PF01134.22 KOO21152.1 - 0.026 13.6 0.0 0.04 13.0 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A ApbA PF02558.16 KOO21152.1 - 0.027 14.1 0.0 0.058 13.0 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AdoHcyase_NAD PF00670.21 KOO21152.1 - 0.028 14.5 0.1 0.052 13.6 0.1 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Pyr_redox_3 PF13738.6 KOO21152.1 - 0.034 13.4 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 KOO21152.1 - 0.061 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 KOO21152.1 - 0.093 12.3 0.2 0.14 11.7 0.2 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FKBP_C PF00254.28 KOO21154.1 - 1.8e-33 114.7 0.0 2.2e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Sod_Cu PF00080.20 KOO21155.1 - 9e-41 139.4 1.2 1.7e-22 80.1 0.3 2.1 2 0 0 2 2 2 2 Copper/zinc superoxide dismutase (SODC) Amidoligase_2 PF12224.8 KOO21156.1 - 4.4e-08 33.1 0.5 0.00032 20.4 0.0 2.4 3 0 0 3 3 3 2 Putative amidoligase enzyme Ala_racemase_N PF01168.20 KOO21157.1 - 1.7e-16 60.5 0.1 2.1e-16 60.2 0.1 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain D-ser_dehydrat PF14031.6 KOO21157.1 - 5.3e-06 27.0 1.1 2.9e-05 24.7 0.1 2.4 1 1 0 2 2 2 1 Putative serine dehydratase domain TPR_1 PF00515.28 KOO21158.1 - 4.2e-27 92.8 20.1 3.8e-06 26.5 0.3 7.1 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21158.1 - 5.1e-23 79.3 31.7 1.3e-05 24.9 0.3 8.3 9 1 1 10 10 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21158.1 - 9.7e-16 57.2 24.5 2.4e-07 30.3 0.6 6.4 7 0 0 7 7 7 3 TPR repeat TPR_16 PF13432.6 KOO21158.1 - 1.3e-13 51.4 27.0 1e-07 32.4 4.3 6.8 6 2 1 7 7 7 3 Tetratricopeptide repeat DnaJ PF00226.31 KOO21158.1 - 6.7e-13 48.6 2.1 1.1e-12 47.8 0.2 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_17 PF13431.6 KOO21158.1 - 8.8e-13 47.7 16.6 0.008 16.5 0.1 8.0 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21158.1 - 1.2e-12 48.1 24.3 2.6e-05 24.6 2.3 6.4 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21158.1 - 8.3e-11 41.2 12.3 0.17 12.2 0.3 6.9 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOO21158.1 - 2.8e-10 40.1 37.7 0.02 15.7 0.1 9.8 5 2 4 9 9 9 5 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO21158.1 - 8.6e-08 32.3 10.4 0.0015 18.7 2.1 3.7 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 KOO21158.1 - 1.3e-07 31.6 24.9 2e-05 24.6 1.5 6.7 5 1 2 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21158.1 - 2.7e-07 30.8 31.3 0.0013 19.0 1.0 6.0 5 1 1 6 6 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21158.1 - 0.00013 21.7 15.2 0.54 10.4 0.1 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO21158.1 - 0.0013 18.7 11.3 2.9 8.0 0.2 5.1 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat RPT PF13446.6 KOO21158.1 - 0.018 14.9 0.1 0.38 10.7 0.0 2.9 2 0 0 2 2 2 0 A repeated domain in UCH-protein MIT PF04212.18 KOO21158.1 - 0.094 12.8 11.9 0.59 10.2 1.1 4.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Sulfotransfer_2 PF03567.14 KOO21158.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Sulfotransferase family SRP_TPR_like PF17004.5 KOO21158.1 - 0.16 12.0 0.4 18 5.3 0.0 2.7 2 1 0 2 2 2 0 Putative TPR-like repeat TPR_6 PF13174.6 KOO21158.1 - 0.18 12.5 23.0 21 6.0 0.2 7.8 7 0 0 7 7 7 0 Tetratricopeptide repeat BTAD PF03704.17 KOO21158.1 - 1 9.8 39.5 0.99 9.8 3.6 6.2 3 1 1 5 5 5 0 Bacterial transcriptional activator domain EF-hand_1 PF00036.32 KOO21159.1 - 1e-25 87.3 7.5 1.7e-05 24.0 0.1 5.3 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 KOO21159.1 - 2.2e-24 83.3 8.6 6.7e-06 25.6 0.3 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 KOO21159.1 - 7.5e-19 68.0 8.8 1.7e-08 34.8 0.2 4.2 3 1 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO21159.1 - 3.7e-17 61.0 11.1 0.0009 18.6 0.2 5.1 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO21159.1 - 1.1e-11 44.3 13.2 0.00048 19.9 0.3 5.1 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO21159.1 - 0.035 14.4 0.0 11 6.4 0.0 3.8 4 0 0 4 4 4 0 EF-hand domain Caleosin PF05042.13 KOO21159.1 - 0.58 10.1 1.6 3 7.7 0.1 2.6 2 1 1 3 3 3 0 Caleosin related protein EF-hand_4 PF12763.7 KOO21159.1 - 0.62 10.0 3.9 12 6.0 0.0 3.7 4 1 1 5 5 5 0 Cytoskeletal-regulatory complex EF hand WW PF00397.26 KOO21160.1 - 7.2e-12 45.2 12.1 5.9e-08 32.7 0.8 2.3 2 0 0 2 2 2 2 WW domain Phage_Arf PF17585.2 KOO21160.1 - 0.0032 17.4 0.0 2 8.4 0.0 2.6 2 0 0 2 2 2 2 Accessory recombination function protein Glyco_hyd_101C PF17451.2 KOO21160.1 - 0.019 15.3 0.2 5.2 7.4 0.0 2.5 2 1 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain SAP PF02037.27 KOO21160.1 - 0.1 12.3 0.0 0.31 10.9 0.0 1.9 1 0 0 1 1 1 0 SAP domain PH PF00169.29 KOO21161.1 - 0.014 15.8 0.0 0.043 14.3 0.0 1.8 1 1 0 1 1 1 0 PH domain Bestrophin PF01062.21 KOO21162.1 - 1.6e-14 54.0 0.0 4.3e-14 52.6 0.0 1.6 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Ion_trans_2 PF07885.16 KOO21162.1 - 0.018 15.0 4.2 0.018 15.0 4.2 2.4 2 1 0 2 2 2 0 Ion channel Mito_carr PF00153.27 KOO21164.1 - 8.1e-09 35.3 3.3 0.36 10.8 0.1 4.0 1 1 3 4 4 4 4 Mitochondrial carrier protein BPS PF08947.10 KOO21164.1 - 0.054 13.3 0.1 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 BPS (Between PH and SH2) TcpQ PF10671.9 KOO21165.1 - 0.019 15.1 2.0 0.019 15.1 2.0 2.1 2 0 0 2 2 2 0 Toxin co-regulated pilus biosynthesis protein Q bZIP_1 PF00170.21 KOO21166.1 - 0.026 14.6 3.1 0.057 13.5 3.1 1.5 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 KOO21166.1 - 0.097 12.8 3.5 0.18 11.9 3.5 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Ion_trans PF00520.31 KOO21167.1 - 2.3e-36 125.3 13.0 2.8e-36 125.0 13.0 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO21167.1 - 0.31 9.7 13.7 0.068 11.8 3.3 2.4 2 1 1 3 3 3 0 Polycystin cation channel EF-hand_7 PF13499.6 KOO21170.1 - 2.8e-24 85.4 9.8 6.8e-10 39.3 1.3 5.3 5 1 1 6 6 6 4 EF-hand domain pair EF-hand_1 PF00036.32 KOO21170.1 - 3e-20 70.2 13.4 0.00015 21.1 0.0 6.9 7 0 0 7 7 7 4 EF hand EF-hand_6 PF13405.6 KOO21170.1 - 6.6e-19 66.2 12.8 0.0018 18.1 0.9 6.8 7 0 0 7 7 7 4 EF-hand domain EF-hand_8 PF13833.6 KOO21170.1 - 1.1e-18 66.9 12.6 5.9e-10 38.8 0.6 5.7 4 2 1 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO21170.1 - 8.7e-09 34.5 14.6 0.003 17.0 0.0 5.5 6 0 0 6 6 6 3 EF hand SPARC_Ca_bdg PF10591.9 KOO21170.1 - 0.01 16.1 1.3 3.4 8.0 0.2 3.6 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO21170.1 - 0.012 15.6 2.2 0.13 12.2 0.5 3.4 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand NPV_P10 PF05531.12 KOO21170.1 - 0.021 15.3 3.1 2.6 8.6 0.0 3.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Med14 PF08638.11 KOO21170.1 - 0.025 14.0 1.8 0.2 11.0 0.0 2.6 3 0 0 3 3 3 0 Mediator complex subunit MED14 p25-alpha PF05517.12 KOO21170.1 - 0.065 13.4 2.9 6.1 7.0 0.1 3.4 2 1 1 3 3 3 0 p25-alpha DUF4201 PF13870.6 KOO21170.1 - 0.076 12.8 3.8 0.47 10.2 0.9 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) PRT_C PF08372.10 KOO21170.1 - 0.099 12.4 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Caleosin PF05042.13 KOO21170.1 - 0.11 12.5 2.2 4.6 7.1 0.1 3.7 3 1 1 4 4 4 0 Caleosin related protein DUF1664 PF07889.12 KOO21170.1 - 0.76 9.8 4.3 5.7 7.0 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 KOO21170.1 - 1.4 9.0 6.0 11 6.0 2.2 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FoP_duplication PF13865.6 KOO21170.1 - 1.8 9.1 5.7 16 6.2 0.1 2.9 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 Prefoldin_2 PF01920.20 KOO21170.1 - 7.7 6.5 11.1 7.3 6.6 0.4 3.4 3 0 0 3 3 3 0 Prefoldin subunit RabGAP-TBC PF00566.18 KOO21171.1 - 9.5e-15 54.8 0.0 1.4e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain IFT57 PF10498.9 KOO21171.1 - 3.8 6.4 5.3 12 4.7 0.9 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 GAS PF13851.6 KOO21171.1 - 4 6.7 11.6 1.8 7.9 4.9 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding B12D PF06522.11 KOO21172.1 - 2.6e-05 23.9 0.0 4.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit UQ_con PF00179.26 KOO21173.1 - 2.7e-45 153.4 0.0 3e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO21173.1 - 2.3e-05 24.1 0.0 2.8e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KOO21173.1 - 0.005 16.7 0.1 0.0077 16.1 0.1 1.4 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 KOO21173.1 - 0.044 14.1 0.2 0.06 13.6 0.2 1.4 1 1 0 1 1 1 0 RWD domain EDR1 PF14381.6 KOO21174.1 - 1e-29 103.7 0.0 1.7e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 Mito_fiss_reg PF05308.11 KOO21174.1 - 0.68 10.0 1.9 1.9 8.5 1.9 1.8 1 0 0 1 1 1 0 Mitochondrial fission regulator FKBP_C PF00254.28 KOO21175.1 - 2.6e-15 56.5 0.0 3.7e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF2810 PF10928.8 KOO21176.1 - 0.0059 16.6 2.5 18 5.5 0.1 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF2810) HIGH_NTase1 PF05636.11 KOO21176.1 - 0.14 11.3 0.2 0.18 11.0 0.2 1.1 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase DUF3720 PF12517.8 KOO21176.1 - 2.3 9.2 6.0 69 4.5 2.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3720) XRN_M PF17846.1 KOO21177.1 - 8.1e-119 397.5 0.0 7.8e-82 275.6 0.0 2.0 2 0 0 2 2 2 2 Xrn1 helical domain Methyltransf_25 PF13649.6 KOO21178.1 - 0.00013 22.6 0.0 0.00019 22.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO21178.1 - 0.0025 18.4 0.0 0.0034 18.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO21178.1 - 0.054 14.2 0.0 0.077 13.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 KOO21178.1 - 0.073 12.7 0.0 0.095 12.3 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) EF-hand_1 PF00036.32 KOO21179.1 - 8.3e-06 25.0 0.5 0.0012 18.2 0.0 2.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO21179.1 - 2.8e-05 24.5 0.0 5.1e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO21179.1 - 3e-05 23.6 0.0 0.0057 16.5 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO21179.1 - 0.00052 19.4 0.0 0.0042 16.5 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO21179.1 - 0.12 12.2 0.4 3.8 7.4 0.2 2.6 2 1 1 3 3 3 0 EF-hand domain pair RRM_1 PF00076.22 KOO21180.1 - 1e-11 44.4 0.0 3.1e-09 36.5 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UVR PF02151.19 KOO21180.1 - 0.06 13.1 0.2 0.11 12.2 0.2 1.4 1 0 0 1 1 1 0 UvrB/uvrC motif ubiquitin PF00240.23 KOO21181.1 - 0.00029 20.5 0.0 0.00088 19.0 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 KOO21181.1 - 0.0034 17.8 0.0 0.0081 16.6 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain AAA_23 PF13476.6 KOO21181.1 - 3.9 7.9 6.3 6.8 7.1 6.3 1.3 1 0 0 1 1 1 0 AAA domain cNMP_binding PF00027.29 KOO21182.1 - 7e-23 80.5 0.0 6.6e-12 45.3 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain GcpE PF04551.14 KOO21183.1 - 3.4e-147 490.1 0.0 6.3e-147 489.2 0.0 1.4 1 1 0 1 1 1 1 GcpE protein Sgf11 PF08209.11 KOO21183.1 - 0.19 11.3 0.9 1.1 8.9 0.1 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Tic22 PF04278.12 KOO21184.1 - 3.3e-11 43.0 0.0 8.8e-11 41.6 0.0 1.6 1 1 0 1 1 1 1 Tic22-like family RhlB PF12300.8 KOO21184.1 - 0.0078 16.4 0.6 0.016 15.4 0.6 1.5 1 0 0 1 1 1 1 ATP-dependent RNA helicase RhlB Rad51 PF08423.11 KOO21186.1 - 2.4e-30 105.6 0.1 4.8e-29 101.4 0.1 2.0 1 1 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KOO21186.1 - 1.4e-09 37.9 0.1 2.5e-09 37.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 KOO21186.1 - 0.0002 20.9 0.1 0.04 13.4 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein DnaB_C PF03796.15 KOO21186.1 - 0.00058 19.3 0.0 0.0015 17.9 0.0 1.6 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 KOO21186.1 - 0.0026 17.1 0.1 0.0097 15.3 0.0 1.8 2 0 0 2 2 2 1 KaiC AAA_16 PF13191.6 KOO21186.1 - 0.038 14.4 0.2 0.079 13.3 0.2 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 KOO21186.1 - 0.077 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KOO21186.1 - 0.17 11.9 0.1 0.72 9.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Hist_deacetyl PF00850.19 KOO21188.1 - 1.3e-79 267.9 0.0 1.7e-79 267.5 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain DnaJ PF00226.31 KOO21189.1 - 9.4e-24 83.3 0.7 2.3e-22 78.9 0.1 2.5 2 0 0 2 2 2 1 DnaJ domain DUF1977 PF09320.11 KOO21189.1 - 0.006 16.8 1.1 0.0089 16.3 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) THDPS_N_2 PF14805.6 KOO21189.1 - 0.54 10.5 6.8 0.12 12.6 1.3 2.5 1 1 1 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal ABC_tran PF00005.27 KOO21190.1 - 1.4e-26 93.7 0.0 1.9e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 KOO21190.1 - 5.2e-06 27.0 0.0 1.6e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain ABC2_membrane PF01061.24 KOO21190.1 - 2.6e-05 23.8 18.5 3.4e-05 23.4 17.1 2.0 1 1 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.6 KOO21190.1 - 3.7e-05 23.7 0.4 0.17 11.6 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KOO21190.1 - 0.00062 19.7 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 KOO21190.1 - 0.0043 16.8 0.1 0.013 15.2 0.1 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad17 PF03215.15 KOO21190.1 - 0.0065 16.4 0.1 0.011 15.6 0.1 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 KOO21190.1 - 0.0085 16.4 0.2 0.028 14.7 0.1 1.9 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 KOO21190.1 - 0.0086 15.5 0.0 3.7 6.9 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 KOO21190.1 - 0.011 15.3 0.5 0.05 13.2 0.1 2.0 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 KOO21190.1 - 0.027 14.4 0.0 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 KOO21190.1 - 0.055 13.9 0.0 0.49 10.8 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 KOO21190.1 - 0.062 12.8 0.0 11 5.5 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Adeno_IVa2 PF02456.15 KOO21190.1 - 0.15 10.8 0.1 0.23 10.2 0.1 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_30 PF13604.6 KOO21190.1 - 0.17 11.6 0.0 1.3 8.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KOO21190.1 - 0.24 11.6 0.1 0.46 10.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KOO21190.1 - 0.33 11.4 0.0 0.53 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Peptidase_S9 PF00326.21 KOO21191.1 - 6.8e-48 162.9 0.0 2.4e-47 161.1 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 KOO21191.1 - 1.4e-09 37.8 0.0 2.4e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 KOO21191.1 - 1.6e-05 24.3 0.3 0.00053 19.3 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase_phd PF10503.9 KOO21191.1 - 0.00093 18.7 1.2 0.0013 18.2 0.1 1.8 2 1 0 2 2 2 1 Esterase PHB depolymerase Abhydrolase_4 PF08386.10 KOO21191.1 - 0.0028 17.7 0.0 0.015 15.4 0.0 2.0 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.20 KOO21191.1 - 0.0063 16.2 0.0 0.017 14.8 0.0 1.7 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 KOO21191.1 - 0.015 15.1 0.1 0.086 12.7 0.1 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold PAE PF03283.13 KOO21191.1 - 0.083 12.0 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Pectinacetylesterase DUF1387 PF07139.11 KOO21192.1 - 0.00062 19.6 10.1 0.00081 19.2 10.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1387) YscO PF07321.12 KOO21192.1 - 4.3 7.3 28.0 0.85 9.6 21.1 2.2 2 0 0 2 2 2 0 Type III secretion protein YscO DUF16 PF01519.16 KOO21192.1 - 4.4 7.9 6.8 3.1 8.4 0.6 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 FH2 PF02181.23 KOO21192.1 - 6 5.9 12.8 0.59 9.2 1.1 2.1 1 1 0 2 2 2 0 Formin Homology 2 Domain Pkinase PF00069.25 KOO21193.1 - 4.4e-36 124.6 0.0 6.8e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21193.1 - 7.5e-15 54.9 0.0 1.7e-14 53.8 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO21193.1 - 0.00016 21.1 0.9 0.00043 19.7 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Fib_alpha PF08702.10 KOO21193.1 - 0.12 12.6 7.9 0.64 10.2 2.6 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SHE3 PF17078.5 KOO21193.1 - 0.8 9.4 12.2 0.026 14.2 4.3 2.2 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Spc7 PF08317.11 KOO21193.1 - 2.8 6.7 36.6 1.7 7.4 10.0 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein Spectrin PF00435.21 KOO21195.1 - 0.014 15.8 0.7 0.023 15.2 0.3 1.5 2 0 0 2 2 2 0 Spectrin repeat PilJ PF13675.6 KOO21195.1 - 0.027 14.5 0.6 0.12 12.4 0.6 1.8 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF892 PF05974.12 KOO21195.1 - 0.04 13.9 0.5 0.048 13.7 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF892) DUF913 PF06025.12 KOO21195.1 - 0.085 11.8 0.1 0.091 11.7 0.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PhdYeFM_antitox PF02604.19 KOO21195.1 - 0.35 10.7 3.6 3.8 7.4 0.1 2.6 1 1 2 3 3 3 0 Antitoxin Phd_YefM, type II toxin-antitoxin system FAD_binding_3 PF01494.19 KOO21197.1 - 1.5e-17 63.9 0.0 2.1e-07 30.5 0.0 2.7 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 KOO21197.1 - 7.7e-05 22.1 0.1 0.0033 16.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO21197.1 - 0.00051 19.2 0.1 0.00083 18.5 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOO21197.1 - 0.00064 19.4 0.7 0.0065 16.1 0.7 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOO21197.1 - 0.0015 18.8 0.1 0.0035 17.5 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 KOO21197.1 - 0.026 13.8 0.1 0.044 13.1 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KOO21197.1 - 0.033 12.9 0.0 0.094 11.4 0.1 1.6 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 KOO21197.1 - 0.064 12.3 0.1 0.11 11.6 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A DUF3553 PF12073.8 KOO21198.1 - 0.13 12.0 1.4 0.46 10.2 1.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3553) tRNA-synt_1b PF00579.25 KOO21200.1 - 1.4e-62 211.7 0.0 2.8e-62 210.7 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) SET PF00856.28 KOO21201.1 - 1.2e-09 38.7 0.0 4e-09 37.1 0.0 1.8 2 0 0 2 2 2 1 SET domain UQ_con PF00179.26 KOO21202.1 - 1.8e-37 128.1 0.0 2.2e-37 127.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Sulfotransfer_3 PF13469.6 KOO21203.1 - 0.0031 17.9 0.0 3.8 7.8 0.0 2.4 2 0 0 2 2 2 2 Sulfotransferase family NMD3 PF04981.13 KOO21204.1 - 6.1e-67 225.6 3.4 9.2e-67 225.0 3.4 1.3 1 0 0 1 1 1 1 NMD3 family Nif11 PF07862.11 KOO21204.1 - 0.0084 16.4 1.1 0.021 15.1 1.1 1.7 1 0 0 1 1 1 1 Nif11 domain DUF521 PF04412.13 KOO21204.1 - 0.11 11.2 0.0 0.19 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Methyltransf_24 PF13578.6 KOO21205.1 - 5.2e-07 30.6 0.1 1.5e-06 29.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain TylF PF05711.11 KOO21205.1 - 0.19 11.0 0.0 0.55 9.5 0.0 1.6 2 0 0 2 2 2 0 Macrocin-O-methyltransferase (TylF) Peptidase_S51 PF03575.17 KOO21206.1 - 2.8e-08 33.7 0.0 7.6e-08 32.2 0.0 1.8 2 0 0 2 2 2 1 Peptidase family S51 Chlorophyllase2 PF12740.7 KOO21206.1 - 0.012 14.5 0.0 0.022 13.7 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.11 KOO21206.1 - 0.052 12.5 0.0 0.09 11.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Abhydrolase_5 PF12695.7 KOO21206.1 - 0.06 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Tme5_EGF_like PF09064.10 KOO21206.1 - 1.5 8.8 8.1 1.6 8.7 2.1 2.7 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Steroid_dh PF02544.16 KOO21207.1 - 1.2e-27 96.7 0.6 1.3e-27 96.6 0.6 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 KOO21207.1 - 1.3e-05 24.8 0.1 1.4e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 KOO21207.1 - 8.8e-05 22.9 0.3 0.00017 21.9 0.3 1.6 1 1 0 1 1 1 1 Phospholipid methyltransferase Aminotran_5 PF00266.19 KOO21208.1 - 3.2e-11 42.8 0.0 2.5e-10 39.9 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V EF-hand_7 PF13499.6 KOO21208.1 - 0.00011 22.6 0.1 0.00022 21.6 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO21208.1 - 0.0012 18.3 2.7 0.0081 15.6 0.3 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO21208.1 - 0.021 14.7 4.1 0.072 13.1 0.4 2.5 2 0 0 2 2 2 0 EF-hand domain Pol_alpha_B_N PF08418.10 KOO21208.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Agenet PF05641.12 KOO21209.1 - 3.4e-05 24.2 0.9 0.5 10.9 0.3 3.2 2 1 0 2 2 2 2 Agenet domain SH3_1 PF00018.28 KOO21209.1 - 0.0053 16.3 0.1 2.9 7.6 0.0 2.4 2 0 0 2 2 2 2 SH3 domain RR_TM4-6 PF06459.12 KOO21209.1 - 1.9 8.3 10.7 2.6 7.8 10.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 HMA PF00403.26 KOO21211.1 - 1.5e-89 294.4 25.1 1.2e-13 51.3 0.2 7.5 7 0 0 7 7 7 7 Heavy-metal-associated domain Hydrolase PF00702.26 KOO21211.1 - 8e-43 147.2 7.1 1.1e-41 143.4 4.9 2.9 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KOO21211.1 - 1.3e-42 145.4 9.3 1.3e-36 125.8 0.4 3.4 2 1 1 3 3 3 2 E1-E2 ATPase Hydrolase_3 PF08282.12 KOO21211.1 - 3.6e-05 23.6 0.2 0.00025 20.9 0.3 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOO21211.1 - 0.00065 20.2 0.6 0.0036 17.7 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase GFA PF04828.14 KOO21211.1 - 0.24 11.8 0.8 17 5.9 0.0 4.0 5 0 0 5 5 5 0 Glutathione-dependent formaldehyde-activating enzyme Rubis-subs-bind PF09273.11 KOO21212.1 - 0.00055 20.6 0.7 0.0012 19.5 0.7 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 KOO21212.1 - 0.15 12.4 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 SET domain RcbX PF02341.15 KOO21213.1 - 0.076 13.3 0.1 17 5.7 0.0 2.6 1 1 1 2 2 2 0 RbcX protein E2F_TDP PF02319.20 KOO21213.1 - 0.089 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain Peptidase_C2 PF00648.21 KOO21214.1 - 4.9e-35 121.0 0.0 7.4e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KOO21214.1 - 0.031 14.5 0.0 0.12 12.6 0.0 1.9 2 0 0 2 2 2 0 Calpain large subunit, domain III GWT1 PF06423.12 KOO21215.1 - 9.2e-24 84.3 0.7 2.3e-23 83.0 0.0 2.1 2 0 0 2 2 2 1 GWT1 DUF1896 PF08989.10 KOO21216.1 - 0.061 13.4 1.1 4 7.5 1.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1896) Peptidase_M50 PF02163.22 KOO21216.1 - 0.1 11.9 0.1 0.22 10.8 0.0 1.5 2 0 0 2 2 2 0 Peptidase family M50 Peptidase_M41 PF01434.18 KOO21216.1 - 0.15 11.9 0.2 0.68 9.7 0.2 1.9 1 1 0 1 1 1 0 Peptidase family M41 Pkinase PF00069.25 KOO21217.1 - 6.2e-53 179.8 0.0 8.5e-53 179.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21217.1 - 3.3e-24 85.6 0.0 5.2e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS_9 PF13426.7 KOO21217.1 - 2.1e-15 56.9 0.0 0.0001 22.5 0.0 4.0 4 0 0 4 4 4 3 PAS domain PAS PF00989.25 KOO21217.1 - 6.3e-08 32.6 0.0 0.0022 18.0 0.0 3.6 3 1 0 3 3 3 2 PAS fold Kinase-like PF14531.6 KOO21217.1 - 3.2e-05 23.4 0.0 5.8e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PAS_4 PF08448.10 KOO21217.1 - 4.6e-05 23.6 0.0 0.0049 17.1 0.0 3.2 3 0 0 3 3 3 1 PAS fold Pkinase_fungal PF17667.1 KOO21217.1 - 0.00043 19.2 0.0 0.00083 18.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO21217.1 - 0.0026 17.1 0.7 0.0046 16.3 0.7 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO21217.1 - 0.0094 15.9 1.6 0.0094 15.9 1.6 2.3 3 1 0 3 3 3 1 Phosphotransferase enzyme family PAS_2 PF08446.11 KOO21217.1 - 0.0098 16.5 0.0 8.2 7.2 0.0 3.0 3 0 0 3 3 3 1 PAS fold RIO1 PF01163.22 KOO21217.1 - 0.013 15.2 0.1 0.023 14.3 0.1 1.3 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 KOO21217.1 - 0.025 14.2 0.0 1.4 8.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PAS_8 PF13188.7 KOO21217.1 - 0.049 13.7 0.0 0.72 9.9 0.0 2.5 2 0 0 2 2 2 0 PAS domain Seadorna_VP7 PF07387.11 KOO21217.1 - 0.23 10.5 0.0 0.38 9.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 NHL PF01436.21 KOO21218.1 - 4.4e-21 73.8 2.5 3.7e-09 36.2 0.1 4.4 3 0 0 3 3 3 3 NHL repeat Cu2_monoox_C PF03712.15 KOO21218.1 - 1.2e-13 50.9 0.0 2e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain SGL PF08450.12 KOO21218.1 - 1.4e-06 28.1 0.2 0.048 13.2 0.2 2.4 1 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Cu2_monooxygen PF01082.20 KOO21218.1 - 1.3e-05 25.4 0.0 3.1e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain US22 PF02393.16 KOO21218.1 - 0.054 13.8 0.0 0.44 10.8 0.0 2.5 2 1 0 2 2 2 0 US22 like DUF839 PF05787.13 KOO21218.1 - 0.062 12.5 0.1 7.5 5.6 0.1 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF839) DUF5128 PF17170.4 KOO21218.1 - 0.077 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 6-bladed beta-propeller SBBP PF06739.11 KOO21218.1 - 0.079 13.0 0.2 3 7.9 0.0 2.9 2 0 0 2 2 2 0 Beta-propeller repeat DUF1952 PF09189.10 KOO21218.1 - 0.11 12.3 0.1 0.3 11.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1952) Notch PF00066.17 KOO21221.1 - 7.3e-07 29.5 6.6 7.3e-07 29.5 6.6 1.8 2 0 0 2 2 2 1 LNR domain WD40 PF00400.32 KOO21222.1 - 7e-20 71.0 8.5 2.2e-05 25.1 0.1 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO21222.1 - 5.3e-14 52.3 0.1 4.6e-05 23.6 0.0 4.2 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 KOO21222.1 - 7e-05 21.9 2.0 0.002 17.1 0.3 2.4 2 1 0 2 2 2 2 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 KOO21222.1 - 0.0014 18.3 0.3 0.0032 17.1 0.3 1.7 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 KOO21222.1 - 0.069 13.1 0.2 0.42 10.6 0.0 2.4 3 0 0 3 3 3 0 PQQ enzyme repeat WD40 PF00400.32 KOO21223.1 - 9.9e-09 35.7 0.1 2e-06 28.4 0.0 2.9 2 0 0 2 2 2 1 WD domain, G-beta repeat TPR_12 PF13424.6 KOO21223.1 - 7e-07 29.5 0.7 4.2e-06 26.9 0.7 2.3 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21223.1 - 9.7e-05 22.2 2.8 0.0098 15.9 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21223.1 - 0.00011 22.0 0.0 0.0012 18.7 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21223.1 - 0.00017 21.3 1.6 0.014 15.2 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21223.1 - 0.011 15.8 0.1 0.039 14.2 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat FinO_N PF12602.8 KOO21223.1 - 0.077 13.3 0.0 0.28 11.5 0.0 2.0 1 0 0 1 1 1 0 Fertility inhibition protein N terminal TPR_14 PF13428.6 KOO21223.1 - 2.3 9.3 0.0 2.3 9.3 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4471 PF14740.6 KOO21224.1 - 2.7e-77 260.0 0.0 7.7e-77 258.5 0.0 1.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4471) DUF4470 PF14737.6 KOO21224.1 - 7.1e-21 74.2 0.0 1.3e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) YL1_C PF08265.11 KOO21224.1 - 4.3e-13 48.8 0.1 1e-12 47.5 0.1 1.7 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain ANAPC_CDC26 PF10471.9 KOO21224.1 - 0.34 11.8 3.7 5.4 7.9 1.7 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 ART PF01129.18 KOO21225.1 - 2.7e-08 33.4 0.0 2.2e-07 30.4 0.0 2.2 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO21225.1 - 4.6e-08 32.7 0.0 8.8e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme FluMu_N PF17891.1 KOO21225.1 - 0.23 11.2 0.3 7.7 6.4 0.0 2.6 2 0 0 2 2 2 0 Mu-like prophage FluMu N-terminal domain Peptidase_S26 PF10502.9 KOO21226.1 - 8.3e-06 25.6 0.0 2.7e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 Signal peptidase, peptidase S26 DUF3391 PF11871.8 KOO21226.1 - 1.7 9.2 7.4 3.8 8.0 7.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) YdaS_antitoxin PF15943.5 KOO21227.1 - 0.12 12.3 0.2 8.6 6.3 0.1 2.6 1 1 1 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT LRR_6 PF13516.6 KOO21228.1 - 1.6e-10 40.2 1.6 0.00028 20.7 0.0 3.6 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 KOO21228.1 - 0.00068 20.0 0.0 0.0049 17.3 0.0 2.1 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO21228.1 - 0.0072 16.1 0.0 0.044 13.5 0.0 2.2 1 1 0 1 1 1 1 Leucine rich repeat TPT PF03151.16 KOO21229.1 - 1.1e-100 336.7 14.9 1.3e-100 336.5 14.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO21229.1 - 9.6e-09 35.5 30.3 0.00011 22.4 9.5 2.5 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO21229.1 - 7.1e-06 25.4 10.3 7.1e-06 25.4 10.3 1.6 1 1 0 2 2 2 1 UAA transporter family Imp-YgjV PF10688.9 KOO21229.1 - 2.5 7.9 19.6 0.21 11.4 2.1 3.3 1 1 2 3 3 3 0 Bacterial inner membrane protein AMP-binding PF00501.28 KOO21230.1 - 1e-36 126.5 0.1 4.5e-20 71.6 0.0 2.2 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 KOO21230.1 - 2.4e-09 38.0 0.1 3.3e-08 34.4 0.0 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Hexapep PF00132.24 KOO21230.1 - 2.4e-08 33.4 4.1 0.0039 16.9 0.0 5.2 6 1 1 7 7 7 3 Bacterial transferase hexapeptide (six repeats) PP-binding PF00550.25 KOO21230.1 - 4.6e-06 26.9 0.0 9.8e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep_2 PF14602.6 KOO21230.1 - 0.036 13.8 9.9 1.2 8.9 0.1 4.5 4 0 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase GH3 PF03321.13 KOO21230.1 - 0.097 11.5 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 GH3 auxin-responsive promoter FeThRed_A PF02941.15 KOO21231.1 - 4e-09 36.5 0.2 4.9e-09 36.2 0.2 1.1 1 0 0 1 1 1 1 Ferredoxin thioredoxin reductase variable alpha chain Mito_carr PF00153.27 KOO21232.1 - 7.3e-20 70.7 7.4 8.2e-11 41.7 0.5 3.6 2 1 2 4 4 4 3 Mitochondrial carrier protein Asp PF00026.23 KOO21233.1 - 1.3e-76 258.1 0.0 1.7e-76 257.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO21233.1 - 8.7e-09 35.9 0.6 5.6e-07 30.0 0.1 2.7 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal COG2 PF06148.11 KOO21234.1 - 2.6e-05 24.3 0.3 4.7e-05 23.5 0.3 1.3 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 LRR_4 PF12799.7 KOO21235.1 - 5.4e-10 39.4 40.9 0.031 14.7 0.2 9.8 9 2 0 11 11 11 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO21235.1 - 2.1e-09 37.0 15.2 6.6e-07 29.0 5.2 8.7 6 3 4 10 10 10 5 Leucine rich repeat Roc PF08477.13 KOO21235.1 - 1.2e-06 28.8 0.0 3.1e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_6 PF13516.6 KOO21235.1 - 5.9e-05 22.8 51.4 0.039 14.0 0.1 12.5 14 0 0 14 14 14 4 Leucine Rich repeat AAA_19 PF13245.6 KOO21235.1 - 0.035 14.4 0.3 0.16 12.3 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 KOO21235.1 - 0.052 14.0 0.0 2.1 8.8 0.0 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Arf PF00025.21 KOO21235.1 - 0.088 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family Ras PF00071.22 KOO21235.1 - 0.11 12.1 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Ras family LRR_1 PF00560.33 KOO21235.1 - 0.37 11.5 22.4 12 6.9 0.0 9.5 11 0 0 11 11 11 0 Leucine Rich Repeat IQ PF00612.27 KOO21236.1 - 5.5e-07 28.8 11.0 0.033 14.0 0.3 3.5 3 0 0 3 3 3 3 IQ calmodulin-binding motif Abhydrolase_3 PF07859.13 KOO21237.1 - 2.1e-40 138.8 0.1 3.5e-40 138.1 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold KIAA1430 PF13879.6 KOO21237.1 - 1.1e-15 58.2 0.1 1.9e-15 57.5 0.1 1.4 1 0 0 1 1 1 1 KIAA1430 homologue Say1_Mug180 PF10340.9 KOO21237.1 - 0.00038 19.4 0.0 0.0019 17.1 0.0 1.9 2 0 0 2 2 2 1 Steryl acetyl hydrolase IQ PF00612.27 KOO21237.1 - 0.00068 19.2 3.4 0.98 9.4 0.1 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif Hydrolase_4 PF12146.8 KOO21237.1 - 0.013 14.8 0.1 0.25 10.5 0.1 2.3 1 1 0 2 2 2 0 Serine aminopeptidase, S33 CUT PF02376.15 KOO21237.1 - 0.13 12.5 0.0 0.57 10.4 0.0 2.1 2 0 0 2 2 2 0 CUT domain Pkinase PF00069.25 KOO21238.1 - 6.9e-77 258.4 0.0 9.1e-77 258.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21238.1 - 1e-42 146.2 0.0 1.4e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO21238.1 - 3.7e-08 33.0 0.0 6.9e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like KA1 PF02149.19 KOO21238.1 - 1.7e-07 30.9 1.6 1.7e-07 30.9 0.1 1.8 2 0 0 2 2 2 1 Kinase associated domain 1 AdenylateSensor PF16579.5 KOO21238.1 - 2.2e-07 31.4 0.0 7.8e-07 29.6 0.0 2.0 1 1 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 KOO21238.1 - 1.9e-05 24.6 0.4 4.4e-05 23.5 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) APH PF01636.23 KOO21238.1 - 0.0041 17.1 0.1 0.093 12.6 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Totivirus_coat PF05518.11 KOO21238.1 - 0.0042 15.2 3.7 0.0057 14.8 3.7 1.1 1 0 0 1 1 1 1 Totivirus coat protein RIO1 PF01163.22 KOO21238.1 - 0.0098 15.5 0.2 0.018 14.6 0.2 1.4 1 0 0 1 1 1 1 RIO1 family DUF2475 PF10629.9 KOO21239.1 - 0.037 14.2 0.1 0.074 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2475) DUF547 PF04784.14 KOO21240.1 - 2.2e-21 76.1 0.0 4.3e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF547 Arm PF00514.23 KOO21240.1 - 7.3e-06 25.8 2.3 0.0023 17.9 0.1 3.7 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Methyltransf_23 PF13489.6 KOO21241.1 - 4.9e-08 33.0 0.0 8.1e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO21241.1 - 3.4e-07 30.9 0.0 6.5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO21241.1 - 1.1e-05 25.9 0.0 2.2e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO21241.1 - 0.0026 18.4 0.0 0.0053 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 KOO21242.1 - 9e-10 39.5 0.4 8e-09 36.5 0.2 2.8 2 0 0 2 2 2 1 Methyltransferase domain MOR2-PAG1_N PF14222.6 KOO21242.1 - 1.1e-09 37.8 0.1 0.00064 18.8 0.0 2.8 2 1 1 3 3 3 2 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 KOO21242.1 - 0.0013 18.7 0.0 0.0047 16.8 0.0 1.9 1 0 0 1 1 1 1 Cell morphogenesis C-terminal DEAD PF00270.29 KOO21243.1 - 7.7e-15 55.1 0.0 1.4e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO21243.1 - 1.8e-05 25.1 0.0 3.3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TPR_11 PF13414.6 KOO21244.1 - 0.037 13.7 0.0 0.096 12.4 0.0 1.8 1 0 0 1 1 1 0 TPR repeat Rad50_zn_hook PF04423.14 KOO21244.1 - 1.6 8.6 6.5 11 5.9 0.3 3.7 2 1 1 3 3 3 0 Rad50 zinc hook motif Pox_A_type_inc PF04508.12 KOO21244.1 - 2.6 8.1 5.8 0.55 10.2 0.1 3.0 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat EamA PF00892.20 KOO21245.1 - 1.4e-10 41.5 30.6 1.3e-06 28.6 11.5 2.1 2 0 0 2 2 2 2 EamA-like transporter family SHIPPO-rpt PF07004.12 KOO21247.1 - 4.6e-08 33.6 11.3 0.22 12.5 0.2 5.3 5 0 0 5 5 5 4 Sperm-tail PG-rich repeat PAP2 PF01569.21 KOO21248.1 - 4.4e-23 81.6 1.4 6.6e-23 81.0 1.4 1.2 1 0 0 1 1 1 1 PAP2 superfamily BTB PF00651.31 KOO21248.1 - 1.1e-08 35.3 0.0 1.6e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain PAP2_3 PF14378.6 KOO21248.1 - 0.085 12.5 6.2 0.74 9.5 6.2 2.1 1 1 0 1 1 1 0 PAP2 superfamily LRR_6 PF13516.6 KOO21250.1 - 1.4e-27 93.3 36.5 0.0061 16.5 0.4 14.8 15 0 0 15 15 15 9 Leucine Rich repeat LRR_1 PF00560.33 KOO21250.1 - 0.00037 20.6 3.2 51 5.0 0.0 8.1 10 1 0 10 10 10 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO21250.1 - 0.00058 20.2 7.3 0.71 10.4 0.0 6.8 6 1 1 7 7 7 1 Leucine Rich repeats (2 copies) PCP PF02429.15 KOO21250.1 - 0.21 11.9 7.3 48 4.3 0.0 5.4 3 2 2 6 6 6 0 Peridinin-chlorophyll A binding protein TM_helix PF05552.12 KOO21250.1 - 2.7 8.0 5.4 68 3.6 0.2 3.6 3 0 0 3 3 3 0 Conserved TM helix Dus PF01207.17 KOO21251.1 - 9.3e-47 159.6 0.0 1.2e-46 159.2 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) FMN_dh PF01070.18 KOO21251.1 - 0.048 12.7 0.0 0.094 11.7 0.0 1.4 1 1 0 1 1 1 0 FMN-dependent dehydrogenase BAH PF01426.18 KOO21253.1 - 2.6e-11 43.4 0.1 3.5e-11 43.0 0.1 1.1 1 0 0 1 1 1 1 BAH domain Na_H_Exchanger PF00999.21 KOO21254.1 - 1.3e-55 188.7 35.8 1.7e-55 188.4 35.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FG-GAP PF01839.23 KOO21254.1 - 0.11 12.7 0.3 0.28 11.4 0.3 1.7 1 0 0 1 1 1 0 FG-GAP repeat NOT2_3_5 PF04153.18 KOO21255.1 - 1.4e-28 99.6 7.5 2.2e-28 99.0 7.5 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family MFS_1 PF07690.16 KOO21256.1 - 3.2e-19 69.1 21.0 5.5e-19 68.3 21.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 KOO21256.1 - 0.0026 16.4 12.6 0.057 12.0 4.1 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein ATG22 PF11700.8 KOO21256.1 - 0.89 8.1 9.5 1.4 7.5 0.2 2.6 3 0 0 3 3 3 0 Vacuole effluxer Atg22 like Oxidored_molyb PF00174.19 KOO21257.1 - 3.4e-59 199.3 0.0 6.8e-59 198.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 KOO21257.1 - 2.8e-46 157.0 0.0 5.4e-46 156.0 0.0 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain FAD_binding_6 PF00970.24 KOO21257.1 - 6.6e-28 97.0 0.0 2.3e-27 95.2 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KOO21257.1 - 1e-25 90.5 0.0 3.1e-25 88.9 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 KOO21257.1 - 5e-24 84.3 0.0 1e-23 83.2 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 KOO21257.1 - 0.00019 21.6 0.0 0.0038 17.4 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Toxin_10 PF05431.11 KOO21257.1 - 0.017 14.6 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 Insecticidal Crystal Toxin, P42 NIR_SIR PF01077.22 KOO21258.1 - 6.8e-52 175.2 0.2 2.6e-38 131.0 0.0 2.6 3 0 0 3 3 3 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 KOO21258.1 - 4.4e-38 129.0 0.0 5.1e-18 64.7 0.0 2.5 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain FR47 PF08445.10 KOO21258.1 - 0.095 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein EcKinase PF02958.20 KOO21261.1 - 1.5e-13 50.8 0.0 3.2e-13 49.7 0.0 1.5 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 KOO21261.1 - 7.4e-09 35.9 0.0 1.3e-08 35.1 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 KOO21261.1 - 1.1e-05 24.6 0.0 1.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) zf-met PF12874.7 KOO21262.1 - 2e-05 24.8 0.6 4.7e-05 23.6 0.6 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type UVR PF02151.19 KOO21262.1 - 0.0012 18.6 3.1 0.0028 17.3 3.1 1.7 1 0 0 1 1 1 1 UvrB/uvrC motif DNA_pol_A_exo1 PF01612.20 KOO21262.1 - 0.0072 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease zf-C2H2_4 PF13894.6 KOO21262.1 - 0.034 15.0 0.9 4 8.5 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOO21262.1 - 0.045 14.1 1.0 0.09 13.1 0.2 1.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 KOO21262.1 - 0.077 12.8 1.6 1.1 9.1 0.1 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type DUF3449 PF11931.8 KOO21262.1 - 0.13 12.1 0.0 0.39 10.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) LUC7 PF03194.15 KOO21262.1 - 0.15 11.7 0.1 0.99 9.0 0.0 1.9 2 0 0 2 2 2 0 LUC7 N_terminus zf-C2H2 PF00096.26 KOO21262.1 - 0.4 11.2 2.1 14 6.4 0.7 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Form_Nir_trans PF01226.17 KOO21263.1 - 8.3e-71 238.1 26.6 1e-70 237.8 26.6 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Metallophos PF00149.28 KOO21264.1 - 3.2e-05 24.5 0.1 5.2e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Methyltransf_25 PF13649.6 KOO21264.1 - 0.0065 17.2 0.2 0.023 15.4 0.1 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO21264.1 - 0.023 14.5 0.0 0.048 13.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Metallophos_2 PF12850.7 KOO21264.1 - 0.028 14.6 0.3 0.19 11.9 0.1 2.1 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain Bin3 PF06859.12 KOO21264.1 - 0.054 14.1 0.0 4.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Bicoid-interacting protein 3 (Bin3) Methyltransf_31 PF13847.6 KOO21264.1 - 0.13 12.0 0.1 0.67 9.7 0.1 2.0 2 0 0 2 2 2 0 Methyltransferase domain PhoR PF11808.8 KOO21264.1 - 0.15 12.5 0.4 0.37 11.3 0.4 1.7 1 0 0 1 1 1 0 Phosphate regulon sensor protein PhoR Mob_synth_C PF06463.13 KOO21266.1 - 4.6e-36 123.6 0.0 7.3e-36 122.9 0.0 1.3 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 KOO21266.1 - 2.9e-28 99.4 0.0 4.7e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 KOO21266.1 - 4.8e-05 23.6 0.0 7.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 KOO21266.1 - 0.0022 18.1 0.0 0.0037 17.4 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Aminotran_1_2 PF00155.21 KOO21267.1 - 9e-47 160.0 0.0 1e-46 159.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KOO21267.1 - 0.0077 15.5 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Myb_DNA-binding PF00249.31 KOO21268.1 - 2.5e-30 104.4 4.9 4.8e-15 55.5 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO21268.1 - 1.6e-24 85.9 0.8 3.4e-14 52.8 0.1 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO21268.1 - 0.0088 15.9 0.1 0.026 14.4 0.0 1.8 1 1 1 2 2 2 1 Myb DNA-binding like Sec1 PF00995.23 KOO21269.1 - 4.8e-111 372.8 0.6 5.8e-111 372.5 0.6 1.0 1 0 0 1 1 1 1 Sec1 family Crp PF00325.20 KOO21269.1 - 0.071 12.8 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family EF-hand_6 PF13405.6 KOO21270.1 - 1.6e-14 52.5 4.5 3e-05 23.6 0.1 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO21270.1 - 5.6e-14 50.6 8.1 2.5e-06 26.6 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO21270.1 - 6.7e-13 48.3 2.0 2e-05 24.4 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO21270.1 - 9e-12 43.9 9.4 0.0007 19.0 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO21270.1 - 2.3e-10 40.8 0.3 4.5e-06 27.0 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain pair DUF3510 PF12022.8 KOO21270.1 - 0.36 11.2 3.5 1.2 9.6 3.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) DUF4407 PF14362.6 KOO21270.1 - 1.1 8.6 17.7 0.061 12.7 10.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF16 PF01519.16 KOO21270.1 - 1.2 9.6 5.1 3.1 8.3 4.9 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 MAT1 PF06391.13 KOO21270.1 - 3.7 7.3 19.4 9.5 6.0 19.4 1.6 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 ABC1 PF03109.16 KOO21271.1 - 7.4e-24 84.2 0.0 1.9e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO21271.1 - 1.2e-06 28.6 0.6 1.2e-05 25.4 0.3 2.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO21271.1 - 0.003 17.0 0.0 0.0049 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SNF2_N PF00176.23 KOO21272.1 - 4.9e-45 153.8 0.0 1.9e-44 151.8 0.0 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain DUF3578 PF12102.8 KOO21272.1 - 2.4e-33 115.2 0.0 6.1e-33 113.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3578) Helicase_C PF00271.31 KOO21272.1 - 4.4e-19 68.9 0.1 1.3e-18 67.4 0.0 1.9 2 0 0 2 2 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 KOO21272.1 - 4.5e-13 48.9 0.0 1.1e-06 28.5 0.1 3.4 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 KOO21272.1 - 5.4e-12 45.4 3.6 1.3e-11 44.2 3.6 1.7 1 0 0 1 1 1 1 PHD-finger zf-CXXC PF02008.20 KOO21272.1 - 8.3e-12 44.9 20.4 5.1e-08 32.8 1.8 2.9 3 0 0 3 3 2 2 CXXC zinc finger domain Agenet PF05641.12 KOO21272.1 - 1.2e-09 38.5 2.2 2.5e-06 27.8 0.0 3.7 3 0 0 3 3 3 1 Agenet domain HDA2-3 PF11496.8 KOO21272.1 - 6.8e-06 25.5 0.0 1.4e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 KOO21272.1 - 8.6e-06 25.8 0.0 5.4e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO21272.1 - 0.0001 22.1 0.0 0.00023 21.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Zf_RING PF16744.5 KOO21272.1 - 0.0013 18.8 0.4 0.0034 17.4 0.4 1.6 1 0 0 1 1 1 1 KIAA1045 RING finger Myb_DNA-binding PF00249.31 KOO21272.1 - 0.0035 17.5 0.0 0.0096 16.1 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain PHD_2 PF13831.6 KOO21272.1 - 0.046 13.3 0.1 0.096 12.3 0.1 1.6 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.22 KOO21272.1 - 0.054 13.4 0.8 0.14 12.0 0.8 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_9 PF13901.6 KOO21272.1 - 0.11 12.4 1.2 0.23 11.4 1.2 1.5 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon DUF2318 PF10080.9 KOO21272.1 - 0.15 12.2 0.6 0.36 11.0 0.6 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) zf-PHD-like PF15446.6 KOO21272.1 - 0.57 9.8 4.3 0.32 10.6 0.3 2.7 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-RING_2 PF13639.6 KOO21272.1 - 1.4 9.3 16.1 0.033 14.5 6.0 3.1 3 0 0 3 3 3 0 Ring finger domain Pkinase PF00069.25 KOO21273.1 - 2.2e-39 135.4 0.0 2.2e-39 135.4 0.0 2.7 2 2 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21273.1 - 2.1e-19 69.8 0.0 1.4e-18 67.1 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO21273.1 - 0.00083 18.7 0.0 0.0033 16.8 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO21273.1 - 0.0072 15.7 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO21273.1 - 0.067 11.9 0.0 0.067 11.9 0.0 2.6 2 1 0 3 3 3 0 Fungal protein kinase Nucleotid_trans PF03407.16 KOO21274.1 - 0.0083 16.1 0.1 0.016 15.2 0.1 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase EF-hand_1 PF00036.32 KOO21275.1 - 8.5e-29 96.9 21.3 1.6e-08 33.5 0.7 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO21275.1 - 6.4e-22 77.8 13.1 1.3e-11 44.8 3.6 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO21275.1 - 4.1e-21 73.5 20.6 1.5e-06 27.4 0.5 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO21275.1 - 7.2e-21 72.3 14.4 2.6e-07 30.0 0.6 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO21275.1 - 1.1e-19 70.0 13.7 3.7e-10 39.5 2.2 4.5 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO21275.1 - 3.9e-05 23.9 0.1 0.058 13.7 0.1 3.3 3 0 0 3 3 3 1 EF-hand domain DUF4764 PF15961.5 KOO21275.1 - 0.00015 20.6 1.5 0.00025 19.9 1.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) zf-C2H2_aberr PF17017.5 KOO21275.1 - 0.0037 17.4 0.2 0.013 15.6 0.0 1.8 2 0 0 2 2 2 1 Aberrant zinc-finger ERAP1_C PF11838.8 KOO21275.1 - 0.018 14.6 0.1 0.077 12.5 0.0 1.9 2 1 0 2 2 2 0 ERAP1-like C-terminal domain PMBR PF09373.10 KOO21275.1 - 0.13 12.4 0.0 3 8.2 0.0 2.4 2 0 0 2 2 2 0 Pseudomurein-binding repeat Caleosin PF05042.13 KOO21275.1 - 1.2 9.0 3.7 7.3 6.5 0.0 2.9 3 0 0 3 3 3 0 Caleosin related protein EF-hand_4 PF12763.7 KOO21275.1 - 1.6 8.7 4.7 5.4 7.0 0.3 2.6 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand PPR_1 PF12854.7 KOO21275.1 - 3.5 7.4 4.1 8 6.3 0.4 2.4 2 0 0 2 2 2 0 PPR repeat NAD_binding_11 PF14833.6 KOO21276.1 - 3e-29 101.7 0.4 7.4e-29 100.5 0.4 1.7 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Hydrolase_like PF13242.6 KOO21276.1 - 2.8e-06 27.3 0.1 5.6e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KOO21276.1 - 5.9e-06 26.5 0.0 6.4e-05 23.1 0.0 2.0 1 1 1 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO21276.1 - 0.014 15.7 1.4 0.039 14.2 1.3 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF2025 PF09634.10 KOO21276.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2025) LRR_8 PF13855.6 KOO21277.1 - 5.2e-44 147.8 27.9 4.7e-09 35.9 0.4 9.3 5 2 1 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 KOO21277.1 - 2e-39 132.9 31.0 4.2e-05 23.8 0.2 11.6 4 2 11 15 15 15 15 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO21277.1 - 1.6e-14 52.7 12.4 0.74 10.0 0.1 11.9 12 0 0 12 12 12 3 Leucine Rich repeat LRR_9 PF14580.6 KOO21277.1 - 1.9e-13 50.3 15.4 0.0022 17.5 0.8 6.4 3 2 2 6 6 6 6 Leucine-rich repeat LRR_1 PF00560.33 KOO21277.1 - 1.3e-05 25.1 31.1 9.3 7.2 0.0 13.1 14 3 1 15 15 15 1 Leucine Rich Repeat VIT PF08487.10 KOO21278.1 - 0.0023 18.1 0.0 0.0041 17.3 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain TauE PF01925.19 KOO21279.1 - 0.036 13.7 17.9 0.68 9.5 18.0 2.5 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE HemY_N PF07219.13 KOO21279.1 - 0.098 12.9 0.3 0.31 11.3 0.3 1.8 1 0 0 1 1 1 0 HemY protein N-terminus SK_channel PF03530.14 KOO21279.1 - 0.1 12.6 2.4 0.1 12.6 0.9 1.8 2 0 0 2 2 2 0 Calcium-activated SK potassium channel DUF4131 PF13567.6 KOO21279.1 - 5.3 6.7 8.5 9.3 5.9 2.2 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) MFS_1 PF07690.16 KOO21280.1 - 2.1e-28 99.3 27.3 8.1e-17 61.2 4.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pam17 PF08566.10 KOO21280.1 - 2.4 8.0 3.6 9.6 6.0 0.4 2.4 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 SKIP_SNW PF02731.15 KOO21281.1 - 3.4e-72 241.3 1.9 3.4e-72 241.3 1.9 1.6 2 0 0 2 2 2 1 SKIP/SNW domain VSP PF03302.13 KOO21282.1 - 0.13 11.1 44.9 0.44 9.4 31.9 3.0 1 1 1 2 2 2 0 Giardia variant-specific surface protein DivIC PF04977.15 KOO21283.1 - 0.0077 16.0 0.7 0.015 15.1 0.7 1.4 1 0 0 1 1 1 1 Septum formation initiator UPF0242 PF06785.11 KOO21283.1 - 0.056 13.5 1.1 0.085 13.0 1.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ZapB PF06005.12 KOO21283.1 - 0.068 13.6 2.2 0.13 12.7 2.2 1.4 1 0 0 1 1 1 0 Cell division protein ZapB Cnn_1N PF07989.11 KOO21283.1 - 0.14 12.3 0.3 0.24 11.6 0.3 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Acetyltransf_10 PF13673.7 KOO21283.1 - 0.18 11.8 0.0 0.5 10.3 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain GrpE PF01025.19 KOO21283.1 - 0.25 11.0 1.0 0.35 10.5 1.0 1.1 1 0 0 1 1 1 0 GrpE EF-hand_1 PF00036.32 KOO21284.1 - 6.8e-14 50.3 1.1 0.00055 19.3 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO21284.1 - 4.8e-13 49.3 0.5 2.5e-08 34.3 0.1 2.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21284.1 - 8.7e-13 47.1 0.8 0.00035 20.3 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KOO21284.1 - 2.1e-09 36.4 4.0 0.00017 21.0 0.3 3.4 3 0 0 3 3 3 2 EF hand Mpv17_PMP22 PF04117.12 KOO21284.1 - 5.2e-09 36.2 0.0 9e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family EF-hand_8 PF13833.6 KOO21284.1 - 5.6e-08 32.5 0.5 0.00058 19.7 0.1 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 KOO21284.1 - 3.2e-05 24.2 0.0 0.0015 18.8 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO21284.1 - 0.00041 20.6 0.0 0.1 12.9 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Methyltransf_24 PF13578.6 KOO21285.1 - 4.3e-14 53.4 0.0 6.6e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO21285.1 - 0.0014 19.3 0.0 0.0023 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO21285.1 - 0.025 15.3 0.0 0.043 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TylF PF05711.11 KOO21285.1 - 0.11 11.8 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) DUF2076 PF09849.9 KOO21286.1 - 1.4e-05 25.3 17.7 3.7e-05 23.9 17.7 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 KOO21286.1 - 0.00089 19.3 6.8 0.0019 18.3 6.8 1.5 1 0 0 1 1 1 1 CHCH domain TPR_11 PF13414.6 KOO21286.1 - 0.003 17.2 0.0 0.0059 16.3 0.0 1.5 1 0 0 1 1 1 1 TPR repeat DUF681 PF05080.12 KOO21286.1 - 0.017 15.8 1.7 0.039 14.6 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF681) 2OG-FeII_Oxy_3 PF13640.6 KOO21286.1 - 0.022 15.6 0.0 0.052 14.4 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily CX9C PF16860.5 KOO21286.1 - 0.14 12.2 1.6 0.3 11.1 1.6 1.6 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, TPR_14 PF13428.6 KOO21286.1 - 7.3 7.7 14.3 0.071 14.0 2.7 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Arm PF00514.23 KOO21288.1 - 1.2e-25 88.7 9.0 6.8e-10 38.6 0.1 4.5 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat O-FucT PF10250.9 KOO21288.1 - 3.2e-09 36.9 0.0 6.9e-09 35.9 0.0 1.4 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase HEAT_EZ PF13513.6 KOO21288.1 - 0.007 16.9 2.2 0.007 16.9 2.2 4.5 2 2 1 3 3 3 1 HEAT-like repeat Glycos_trans_3N PF02885.17 KOO21288.1 - 0.049 13.5 0.2 0.12 12.2 0.2 1.6 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain HEAT_2 PF13646.6 KOO21288.1 - 0.88 10.0 11.3 0.34 11.3 5.2 3.0 1 1 2 3 3 3 0 HEAT repeats ATG16 PF08614.11 KOO21289.1 - 0.01 16.1 4.3 0.015 15.5 4.3 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Alpha_TIF PF02232.15 KOO21289.1 - 0.021 14.0 0.1 0.034 13.3 0.1 1.3 1 0 0 1 1 1 0 Alpha trans-inducing protein (Alpha-TIF) Atg14 PF10186.9 KOO21289.1 - 0.034 13.2 0.6 0.041 13.0 0.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlxA PF14282.6 KOO21289.1 - 0.054 13.5 0.8 0.09 12.8 0.8 1.3 1 0 0 1 1 1 0 FlxA-like protein K-box PF01486.17 KOO21289.1 - 0.06 13.5 2.0 0.1 12.8 2.0 1.3 1 0 0 1 1 1 0 K-box region DUF5320 PF17253.2 KOO21289.1 - 0.18 12.9 0.4 0.4 11.8 0.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5320) OmpH PF03938.14 KOO21289.1 - 0.41 11.0 3.8 0.6 10.4 3.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Trypan_PARP PF05887.11 KOO21290.1 - 0.27 11.2 7.5 0.44 10.5 7.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Brix PF04427.18 KOO21291.1 - 1.1e-28 100.7 0.3 1.4e-28 100.3 0.3 1.1 1 0 0 1 1 1 1 Brix domain Bromodomain PF00439.25 KOO21291.1 - 0.14 12.3 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Bromodomain XPA_C PF05181.12 KOO21292.1 - 0.68 10.0 4.1 5.5 7.0 0.4 2.7 2 0 0 2 2 2 0 XPA protein C-terminus PP2C PF00481.21 KOO21293.1 - 3.4e-38 131.8 0.0 4.5e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO21293.1 - 2.5e-05 24.0 1.5 8e-05 22.4 1.4 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO21293.1 - 0.00023 21.1 0.1 0.0032 17.4 0.0 2.1 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) TIG PF01833.24 KOO21294.1 - 2.8e-17 62.6 8.1 6.5e-08 32.6 0.7 4.2 4 1 0 4 4 4 3 IPT/TIG domain TIG_plexin PF17960.1 KOO21294.1 - 0.0002 21.3 0.0 2.2 8.3 0.0 3.2 3 0 0 3 3 3 2 TIG domain Gly-zipper_OmpA PF13436.6 KOO21295.1 - 0.03 14.1 2.5 0.03 14.1 2.5 2.0 3 0 0 3 3 3 0 Glycine-zipper domain SMK-1 PF04802.15 KOO21296.1 - 5.6e-61 205.7 0.3 5.6e-61 205.7 0.3 1.7 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 LON_substr_bdg PF02190.16 KOO21297.1 - 4.1e-05 23.5 0.1 0.00012 22.0 0.1 1.8 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AATF-Che1 PF13339.6 KOO21297.1 - 0.074 13.7 0.1 0.15 12.7 0.1 1.6 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF1328 PF07043.13 KOO21297.1 - 0.38 11.0 2.3 0.67 10.2 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1328) Mst1_SARAH PF11629.8 KOO21297.1 - 0.83 9.8 3.3 4.1 7.6 1.4 2.6 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 TPR_1 PF00515.28 KOO21298.1 - 0.032 14.1 1.7 8.1 6.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 KOO21298.1 - 0.08 13.0 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_9 PF13371.6 KOO21298.1 - 0.34 11.1 11.9 2.6 8.3 3.3 3.6 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21298.1 - 0.84 9.9 6.8 51 4.3 0.0 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21298.1 - 1.1 9.5 10.4 0.079 13.3 1.1 3.4 3 1 0 4 4 4 0 Tetratricopeptide repeat AAA PF00004.29 KOO21299.1 - 2.3e-94 312.8 0.0 3.8e-46 156.8 0.0 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO21299.1 - 2.4e-29 100.9 5.2 6.2e-16 57.9 1.3 2.9 2 0 0 2 2 2 2 AAA+ lid domain EF-hand_1 PF00036.32 KOO21299.1 - 2.6e-28 95.4 12.2 1.6e-06 27.2 0.2 5.0 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO21299.1 - 9.4e-28 96.5 2.6 2.2e-13 50.4 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain pair CDC48_N PF02359.18 KOO21299.1 - 4.5e-24 84.4 0.8 5.4e-23 81.0 0.1 2.9 3 0 0 3 3 2 1 Cell division protein 48 (CDC48), N-terminal domain EF-hand_8 PF13833.6 KOO21299.1 - 4.2e-21 74.6 5.5 5.3e-10 39.0 0.2 4.5 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO21299.1 - 1.5e-18 65.1 13.3 7e-06 25.6 0.2 5.2 5 0 0 5 5 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO21299.1 - 2.9e-17 61.3 12.1 8.7e-05 21.8 0.0 5.1 4 0 0 4 4 4 4 EF hand RuvB_N PF05496.12 KOO21299.1 - 1.4e-13 50.9 0.0 2.5e-05 24.1 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KOO21299.1 - 3.1e-13 50.2 0.0 2.8e-06 27.5 0.0 3.3 4 0 0 4 4 2 2 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.17 KOO21299.1 - 2.7e-12 46.3 0.0 5.6e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.6 KOO21299.1 - 5e-11 43.0 0.0 1.5e-05 25.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOO21299.1 - 8.3e-11 42.6 0.2 0.0011 19.4 0.0 3.9 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 KOO21299.1 - 1.6e-10 41.1 0.0 3.3e-05 23.9 0.0 3.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO21299.1 - 2.4e-09 37.6 0.5 0.064 13.5 0.0 4.6 4 2 1 5 5 3 2 AAA domain EF-hand_9 PF14658.6 KOO21299.1 - 2.4e-08 34.2 0.3 5.5e-05 23.4 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain TIP49 PF06068.13 KOO21299.1 - 3.3e-08 33.1 0.0 0.0019 17.5 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_14 PF13173.6 KOO21299.1 - 2.2e-07 31.0 0.0 0.018 15.0 0.0 2.8 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.21 KOO21299.1 - 3.9e-07 29.7 0.3 0.032 13.6 0.1 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KOO21299.1 - 1.5e-06 28.8 0.0 0.096 13.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 KOO21299.1 - 1.8e-06 27.9 0.0 0.0028 17.4 0.0 3.2 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 KOO21299.1 - 2.1e-06 28.1 0.0 0.009 16.4 0.0 3.0 3 0 0 3 3 2 2 RNA helicase Vps4_C PF09336.10 KOO21299.1 - 2.1e-06 27.6 0.8 2.8e-05 24.0 0.1 3.0 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 KOO21299.1 - 3.3e-06 26.9 0.1 0.067 12.9 0.0 2.7 2 1 0 2 2 2 2 IstB-like ATP binding protein ABC_tran PF00005.27 KOO21299.1 - 1.3e-05 25.7 0.1 0.028 15.0 0.0 3.3 2 1 0 2 2 2 1 ABC transporter AAA_17 PF13207.6 KOO21299.1 - 3.2e-05 24.4 0.3 0.37 11.2 0.0 3.3 3 1 1 4 4 2 2 AAA domain ATPase_2 PF01637.18 KOO21299.1 - 4.3e-05 23.5 1.8 0.23 11.4 0.0 4.1 3 2 1 4 4 4 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 KOO21299.1 - 4.9e-05 23.6 0.1 0.35 11.1 0.0 3.1 3 0 0 3 3 3 2 AAA domain Zeta_toxin PF06414.12 KOO21299.1 - 8.1e-05 22.0 0.0 0.43 9.8 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin ATPase PF06745.13 KOO21299.1 - 0.00011 21.7 0.1 2.7 7.3 0.0 3.7 3 0 0 3 3 3 1 KaiC Sigma54_activat PF00158.26 KOO21299.1 - 0.00011 21.9 0.0 0.75 9.5 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 KOO21299.1 - 0.00012 21.7 0.0 0.15 11.6 0.0 2.7 2 1 0 2 2 2 1 P-loop containing dynein motor region Parvo_NS1 PF01057.17 KOO21299.1 - 0.00015 21.0 0.1 0.038 13.1 0.0 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 KOO21299.1 - 0.00015 21.4 2.0 3 7.4 0.0 4.2 3 1 0 4 4 4 0 AAA domain Bac_DnaA PF00308.18 KOO21299.1 - 0.00015 21.7 0.0 0.67 9.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial dnaA protein TsaE PF02367.17 KOO21299.1 - 0.00032 20.7 0.0 0.23 11.4 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 KOO21299.1 - 0.00046 20.3 0.0 1 9.5 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain SPARC_Ca_bdg PF10591.9 KOO21299.1 - 0.00047 20.5 0.0 1.5 9.1 0.0 2.6 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region NACHT PF05729.12 KOO21299.1 - 0.00077 19.4 0.1 0.29 11.0 0.0 3.0 3 0 0 3 3 2 1 NACHT domain NB-ARC PF00931.22 KOO21299.1 - 0.0009 18.5 0.0 0.29 10.3 0.0 2.7 2 0 0 2 2 2 1 NB-ARC domain AAA_24 PF13479.6 KOO21299.1 - 0.00094 19.0 0.2 1.9 8.2 0.0 2.8 2 1 0 2 2 2 2 AAA domain UFD1 PF03152.14 KOO21299.1 - 0.001 18.5 0.0 0.0021 17.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 EF-hand_4 PF12763.7 KOO21299.1 - 0.0016 18.3 0.6 0.12 12.4 0.1 2.5 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand AAA_3 PF07726.11 KOO21299.1 - 0.0017 18.2 0.0 2 8.3 0.0 3.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 KOO21299.1 - 0.002 17.6 0.2 2.4 7.6 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.15 KOO21299.1 - 0.0027 17.7 0.0 0.53 10.3 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 KOO21299.1 - 0.004 16.4 0.1 2.4 7.3 0.0 2.8 3 0 0 3 3 2 1 Uncharacterized conserved protein (DUF2075) Cytidylate_kin2 PF13189.6 KOO21299.1 - 0.0062 16.7 0.1 1 9.5 0.0 2.9 3 0 0 3 3 2 1 Cytidylate kinase-like family Rad17 PF03215.15 KOO21299.1 - 0.0075 16.2 0.0 0.84 9.5 0.0 2.7 2 0 0 2 2 2 1 Rad17 P-loop domain DUF815 PF05673.13 KOO21299.1 - 0.008 15.4 0.0 0.3 10.2 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 KOO21299.1 - 0.0088 16.4 2.5 18 5.6 0.0 4.4 5 1 0 6 6 3 0 AAA domain NTPase_1 PF03266.15 KOO21299.1 - 0.013 15.4 1.6 6.5 6.6 0.0 4.6 6 0 0 6 6 4 0 NTPase UPF0154 PF03672.13 KOO21299.1 - 0.018 15.0 0.0 2.7 8.1 0.0 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) TerB PF05099.13 KOO21299.1 - 0.022 14.7 4.4 1.6 8.7 1.1 3.3 2 1 1 3 3 2 0 Tellurite resistance protein TerB SKI PF01202.22 KOO21299.1 - 0.029 14.5 0.4 11 6.1 0.0 3.2 3 0 0 3 3 2 0 Shikimate kinase AAA_11 PF13086.6 KOO21299.1 - 0.065 13.0 0.3 10 5.8 0.0 2.8 3 0 0 3 3 2 0 AAA domain Cytidylate_kin PF02224.18 KOO21299.1 - 0.071 12.8 0.3 11 5.7 0.0 2.7 3 0 0 3 3 2 0 Cytidylate kinase AAA_30 PF13604.6 KOO21299.1 - 0.073 12.8 0.4 23 4.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain KAP_NTPase PF07693.14 KOO21299.1 - 0.089 12.0 0.0 0.8 8.9 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain PduV-EutP PF10662.9 KOO21299.1 - 0.094 12.5 0.0 4 7.2 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Zot PF05707.12 KOO21299.1 - 0.18 11.4 0.0 2.3 7.8 0.0 2.6 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) WD40_3 PF15911.5 KOO21300.1 - 2.9e-16 59.2 0.0 6.5e-16 58.1 0.0 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO21300.1 - 3.2e-07 30.6 0.7 2.2 8.6 0.0 4.8 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 KOO21300.1 - 0.00017 20.8 1.8 0.011 14.8 0.1 3.0 3 0 0 3 3 3 1 Coatomer WD associated region Clathrin PF00637.20 KOO21300.1 - 0.00073 19.4 0.8 12 5.8 0.0 3.9 3 1 1 4 4 4 1 Region in Clathrin and VPS IKI3 PF04762.12 KOO21300.1 - 0.0017 16.4 0.0 0.0073 14.4 0.0 1.8 2 0 0 2 2 2 1 IKI3 family WD40 PF00400.32 KOO21300.1 - 0.014 16.3 0.1 2.8 9.0 0.0 4.1 4 0 0 4 4 3 0 WD domain, G-beta repeat eIF2A PF08662.11 KOO21300.1 - 0.019 14.8 0.0 0.22 11.4 0.0 2.4 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A TPR_7 PF13176.6 KOO21300.1 - 0.042 13.9 8.8 1.7e+02 2.6 0.0 6.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO21300.1 - 0.051 13.5 3.6 5 7.1 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 KOO21300.1 - 0.53 10.4 8.7 16 5.7 0.1 4.5 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Nic96 PF04097.14 KOO21300.1 - 1.1 7.7 4.3 6.4 5.1 0.1 3.2 3 1 1 4 4 4 0 Nup93/Nic96 TPR_14 PF13428.6 KOO21300.1 - 2.2 9.3 18.9 61 4.8 0.1 7.0 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21300.1 - 4.8 7.0 8.6 28 4.5 0.1 4.8 5 0 0 5 5 5 0 TPR repeat PPR_2 PF13041.6 KOO21302.1 - 6.8e-18 64.6 0.0 3.1e-06 27.3 0.0 6.7 5 2 2 7 7 7 5 PPR repeat family PPR_long PF17177.4 KOO21302.1 - 1.3e-14 54.1 2.0 1.4e-07 31.1 0.6 4.3 5 1 0 5 5 5 2 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 KOO21302.1 - 3e-10 40.0 0.0 0.011 15.8 0.0 6.1 5 1 1 6 6 6 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 KOO21302.1 - 0.00014 21.5 0.0 0.39 10.5 0.0 4.9 5 1 0 5 5 5 1 PPR repeat PPR PF01535.20 KOO21302.1 - 0.00029 20.9 0.7 5.9 7.4 0.0 5.4 4 1 0 4 4 4 1 PPR repeat FtsJ PF01728.19 KOO21302.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.7 1 1 0 1 1 1 0 FtsJ-like methyltransferase TB2_DP1_HVA22 PF03134.19 KOO21303.1 - 4e-08 33.1 15.2 1.6e-05 24.7 0.4 4.1 3 1 0 3 3 3 2 TB2/DP1, HVA22 family IBR PF01485.21 KOO21304.1 - 0.032 14.5 15.9 0.072 13.3 15.9 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain WD40 PF00400.32 KOO21305.1 - 2.1e-44 148.6 12.9 5.2e-12 46.1 0.5 7.8 8 0 0 8 8 8 5 WD domain, G-beta repeat Katanin_con80 PF13925.6 KOO21305.1 - 1.1e-27 97.0 0.0 1.9e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 con80 domain of Katanin ANAPC4_WD40 PF12894.7 KOO21305.1 - 5.1e-14 52.4 0.0 0.00044 20.5 0.0 5.1 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO21305.1 - 4.3e-07 30.0 0.0 0.00053 19.9 0.0 1.9 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOO21305.1 - 0.002 16.9 0.4 6.7 5.2 0.0 3.3 3 1 0 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOO21305.1 - 0.0036 16.3 0.8 0.14 11.1 0.2 2.9 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 KOO21305.1 - 0.18 10.3 0.0 0.44 9.0 0.0 1.6 1 1 0 1 1 1 0 Cytochrome D1 heme domain Frtz PF11768.8 KOO21305.1 - 0.26 9.5 0.0 0.84 7.9 0.0 1.7 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz HEAT PF02985.22 KOO21305.1 - 1.1 9.7 3.1 4.3 7.9 0.1 3.2 3 0 0 3 3 3 0 HEAT repeat SlyX PF04102.12 KOO21306.1 - 0.18 12.5 9.3 0.25 12.0 3.7 2.2 2 0 0 2 2 2 0 SlyX Porin_3 PF01459.22 KOO21307.1 - 0.00034 20.2 0.0 0.0093 15.5 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic porin Isochorismatase PF00857.20 KOO21308.1 - 4.2e-21 75.9 0.1 5.6e-13 49.4 0.0 2.2 2 0 0 2 2 2 2 Isochorismatase family RNase_T PF00929.24 KOO21309.1 - 0.00082 20.0 0.0 0.0017 19.0 0.0 1.6 1 1 0 1 1 1 1 Exonuclease DIMCO_N PF16844.5 KOO21309.1 - 0.078 13.3 0.0 3.1 8.2 0.0 3.0 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal Pkinase PF00069.25 KOO21310.1 - 2.4e-47 161.5 0.0 2.8e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21310.1 - 5e-22 78.4 0.1 7.1e-22 77.9 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 KOO21310.1 - 0.00025 20.7 0.0 0.00047 19.8 0.0 1.4 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 KOO21310.1 - 0.0076 15.9 0.0 1 9.0 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KOO21310.1 - 0.011 15.1 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO21310.1 - 0.057 13.3 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DEAD_2 PF06733.15 KOO21311.1 - 6.2e-46 156.2 0.0 1.9e-45 154.6 0.0 1.9 1 1 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 KOO21311.1 - 7.9e-41 140.1 0.0 1.7e-40 138.9 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.11 KOO21311.1 - 9.8e-29 100.4 2.6 2.5e-23 82.7 1.0 3.4 2 1 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 KOO21311.1 - 8.5e-09 35.6 0.0 6e-06 26.4 0.0 2.6 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit SNF2_N PF00176.23 KOO21311.1 - 0.00082 18.2 0.0 0.2 10.3 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain AAA_11 PF13086.6 KOO21311.1 - 0.023 14.5 0.2 0.066 13.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 KOO21311.1 - 0.11 11.7 0.0 10 5.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PMM PF03332.13 KOO21312.1 - 1.1e-94 316.4 0.0 1.2e-94 316.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 KOO21312.1 - 6.8e-06 26.0 0.0 1.5e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TPR_12 PF13424.6 KOO21313.1 - 3.4e-36 123.4 35.3 3.3e-16 59.3 3.6 4.5 2 2 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO21313.1 - 1.3e-32 110.8 37.9 7.4e-09 35.2 0.2 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21313.1 - 4.2e-21 73.8 7.0 0.001 18.8 0.5 6.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21313.1 - 2.9e-19 67.5 18.2 0.0033 17.4 0.1 6.9 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21313.1 - 4e-17 60.9 0.8 0.018 15.2 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21313.1 - 2.4e-16 58.5 17.9 0.047 13.7 0.3 7.1 6 1 0 6 6 6 6 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21313.1 - 8.6e-11 42.3 51.1 0.0002 21.9 10.0 6.3 1 1 4 5 5 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOO21313.1 - 1.9e-08 34.4 42.9 0.086 13.7 0.7 7.1 5 2 2 7 7 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21313.1 - 8.5e-08 31.8 4.9 0.2 11.3 0.1 6.4 6 1 0 6 6 6 1 TPR repeat TPR_19 PF14559.6 KOO21313.1 - 4.6e-06 27.0 28.2 0.00025 21.5 1.1 5.8 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO21313.1 - 0.00034 20.8 4.5 13 6.5 0.0 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO21313.1 - 0.0021 18.6 9.8 21 6.0 0.1 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF1442 PF07279.11 KOO21313.1 - 0.0097 15.2 0.2 0.21 10.9 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1442) 2-ph_phosp PF04029.14 KOO21313.1 - 0.017 14.3 0.1 0.066 12.4 0.0 1.9 2 0 0 2 2 2 0 2-phosphosulpholactate phosphatase DUF3856 PF12968.7 KOO21313.1 - 0.018 15.1 7.8 0.38 10.8 1.2 3.2 1 1 2 3 3 3 0 Domain of Unknown Function (DUF3856) TPR_MalT PF17874.1 KOO21313.1 - 0.032 13.6 20.7 0.069 12.5 1.0 2.5 3 0 0 3 3 3 0 MalT-like TPR region TPR_4 PF07721.14 KOO21313.1 - 0.21 12.3 0.0 0.21 12.3 0.0 9.6 9 2 1 10 10 7 0 Tetratricopeptide repeat Na_Ca_ex PF01699.24 KOO21314.1 - 2.2e-53 180.2 39.8 1.7e-27 96.2 16.2 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Pep1_7 PF17232.2 KOO21314.1 - 0.00036 20.9 0.2 0.00064 20.1 0.2 1.3 1 0 0 1 1 1 1 Elicitor peptide 1-7 Voldacs PF03517.13 KOO21314.1 - 0.029 14.5 0.1 0.055 13.6 0.1 1.4 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling CPSase_L_D2 PF02786.17 KOO21315.1 - 9.5e-106 352.0 0.0 5.7e-78 261.2 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 KOO21315.1 - 3.4e-50 169.2 0.0 6.8e-50 168.2 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 KOO21315.1 - 3.5e-42 144.3 0.0 1.3e-41 142.5 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 KOO21315.1 - 1.7e-38 131.7 0.1 4e-38 130.5 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 KOO21315.1 - 3.4e-19 69.0 0.0 2e-11 43.8 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KOO21315.1 - 9.6e-18 64.5 0.0 7.2e-10 38.7 0.0 2.3 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus MGS PF02142.22 KOO21315.1 - 3.6e-15 55.9 0.0 1e-14 54.5 0.0 1.9 1 0 0 1 1 1 1 MGS-like domain ATPgrasp_Ter PF15632.6 KOO21315.1 - 2.3e-14 53.3 0.1 4.6e-07 29.6 0.0 3.6 4 1 0 4 4 4 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 KOO21315.1 - 0.00018 21.4 0.1 0.023 14.4 0.1 2.5 1 1 0 2 2 2 1 Peptidase C26 ATP-grasp_3 PF02655.14 KOO21315.1 - 0.017 15.1 0.0 0.29 11.2 0.0 2.5 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.11 KOO21315.1 - 0.02 14.5 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain CoA_binding_2 PF13380.6 KOO21315.1 - 0.18 12.3 0.0 2.4 8.7 0.0 2.8 2 0 0 2 2 2 0 CoA binding domain RNase_T PF00929.24 KOO21316.1 - 5.5e-10 40.0 0.0 8.3e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Exonuclease 2OG-Fe_Oxy_2 PF10014.9 KOO21317.1 - 0.0038 17.0 0.0 0.0069 16.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe dioxygenase TPR_2 PF07719.17 KOO21318.1 - 0.002 18.1 0.2 0.68 10.2 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21318.1 - 0.083 12.6 0.3 7 6.4 0.0 2.4 1 1 1 2 2 2 0 TPR repeat TPR_14 PF13428.6 KOO21318.1 - 0.21 12.5 0.2 0.21 12.5 0.2 5.0 4 2 1 5 5 5 0 Tetratricopeptide repeat Steroid_dh PF02544.16 KOO21319.1 - 8.8e-51 171.8 0.0 1e-50 171.6 0.0 1.0 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 KOO21319.1 - 8.2e-05 22.2 0.1 0.0001 21.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) AAA_23 PF13476.6 KOO21320.1 - 1.5e-31 110.5 0.1 1.5e-31 110.5 0.1 7.4 2 2 1 3 3 3 1 AAA domain AAA_15 PF13175.6 KOO21320.1 - 1.9e-08 34.4 0.4 1.9e-08 34.4 0.4 3.8 3 1 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 KOO21320.1 - 4.4e-06 26.7 9.7 0.0015 18.4 0.1 3.3 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system TMF_TATA_bd PF12325.8 KOO21320.1 - 0.0063 16.7 14.3 0.0063 16.7 14.3 10.4 6 4 3 11 11 11 1 TATA element modulatory factor 1 TATA binding ABC_tran PF00005.27 KOO21320.1 - 0.0078 16.7 0.0 0.0078 16.7 0.0 6.2 2 1 1 3 3 3 1 ABC transporter AAA_29 PF13555.6 KOO21320.1 - 0.0081 15.9 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO21320.1 - 0.072 13.4 0.0 0.072 13.4 0.0 5.2 5 2 1 6 6 6 0 AAA domain AAA_13 PF13166.6 KOO21320.1 - 0.11 11.2 0.0 0.11 11.2 0.0 7.7 3 2 2 7 7 7 0 AAA domain SMC_N PF02463.19 KOO21320.1 - 6.6 6.1 42.8 1.1e+02 2.1 42.8 2.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain UPF0029 PF01205.19 KOO21321.1 - 1.4e-20 73.6 0.0 2.2e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 PPR_2 PF13041.6 KOO21323.1 - 8.2e-05 22.7 0.0 0.00016 21.8 0.0 1.5 1 0 0 1 1 1 1 PPR repeat family Ribosomal_L19e PF01280.20 KOO21324.1 - 0.077 13.1 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L19e Histone PF00125.24 KOO21326.1 - 1.2e-49 168.0 1.1 1.4e-49 167.8 1.1 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KOO21326.1 - 0.00019 21.5 0.0 0.00035 20.6 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KOO21326.1 - 0.00076 19.8 0.0 0.0013 19.1 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 KOO21326.1 - 0.0068 16.7 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF3431 PF11913.8 KOO21328.1 - 0.083 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3431) Aminotran_1_2 PF00155.21 KOO21330.1 - 2.3e-73 247.5 0.0 2.6e-73 247.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II RAP PF08373.10 KOO21331.1 - 1.3e-13 50.8 0.0 2.1e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 KOO21331.1 - 5.6e-05 23.2 0.0 9.3e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 REase_MTES_1575 FAST_1 PF06743.15 KOO21331.1 - 0.014 15.3 0.0 0.099 12.6 0.0 2.4 2 1 1 3 3 3 0 FAST kinase-like protein, subdomain 1 FAST_2 PF08368.12 KOO21331.1 - 0.018 15.8 0.0 0.032 15.0 0.0 1.3 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 2 Sulfatase PF00884.23 KOO21332.1 - 1.2e-19 70.8 1.1 2.1e-19 70.0 1.1 1.4 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 KOO21332.1 - 3.2e-06 27.3 0.1 7e-06 26.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) LRR_6 PF13516.6 KOO21333.1 - 3.2e-52 170.2 22.2 8.2e-05 22.4 0.1 10.4 10 0 0 10 10 10 10 Leucine Rich repeat LRR_4 PF12799.7 KOO21333.1 - 5.2e-10 39.4 14.8 0.11 13.0 0.0 7.5 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO21333.1 - 2e-07 30.6 0.0 14 6.7 0.0 8.1 9 0 0 9 9 9 1 Leucine Rich Repeat SpoU_sub_bind PF08032.12 KOO21333.1 - 0.0034 17.6 4.1 2.2 8.6 0.0 4.4 2 2 2 4 4 4 2 RNA 2'-O ribose methyltransferase substrate binding LRR_8 PF13855.6 KOO21333.1 - 0.092 12.5 16.7 29 4.5 0.5 7.4 5 3 0 5 5 5 0 Leucine rich repeat ART PF01129.18 KOO21334.1 - 2.2e-15 56.6 0.0 3e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO21334.1 - 2.1e-08 33.8 0.0 6.3e-08 32.2 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Ribosomal_S17 PF00366.20 KOO21335.1 - 3.8e-21 75.0 0.1 4.6e-21 74.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 XPG_I_2 PF12813.7 KOO21336.1 - 0.017 14.6 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 XPG domain containing XPG_I PF00867.18 KOO21336.1 - 0.12 12.7 0.0 0.31 11.4 0.0 1.8 1 0 0 1 1 1 0 XPG I-region CoA_trans PF01144.23 KOO21337.1 - 6.6e-97 323.1 0.5 2.1e-60 203.8 0.1 2.2 2 0 0 2 2 2 2 Coenzyme A transferase DUF1295 PF06966.12 KOO21337.1 - 2.3e-13 50.2 0.3 3.4e-13 49.6 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 KOO21337.1 - 4e-05 23.9 0.0 9.6e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family AcetylCoA_hyd_C PF13336.6 KOO21337.1 - 0.00019 21.4 0.0 0.00044 20.2 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain PEMT PF04191.13 KOO21337.1 - 0.0011 19.3 1.6 0.0045 17.4 0.1 2.4 1 1 1 2 2 2 1 Phospholipid methyltransferase Crystall PF00030.19 KOO21337.1 - 0.038 14.2 0.0 0.99 9.7 0.0 2.3 2 0 0 2 2 2 0 Beta/Gamma crystallin ERG4_ERG24 PF01222.17 KOO21337.1 - 0.056 12.2 0.1 0.2 10.4 0.2 1.7 1 1 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family Steroid_dh PF02544.16 KOO21337.1 - 0.18 11.8 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase TIR_2 PF13676.6 KOO21338.1 - 1.3e-06 29.0 0.1 1.5e-05 25.6 0.0 2.6 2 0 0 2 2 2 1 TIR domain THRAP3_BCLAF1 PF15440.6 KOO21338.1 - 0.11 11.5 30.9 0.13 11.2 30.9 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family RNA_pol_Rpb1_5 PF04998.17 KOO21338.1 - 0.96 8.8 0.0 0.96 8.8 0.0 2.5 1 1 1 2 2 2 0 RNA polymerase Rpb1, domain 5 VWA PF00092.28 KOO21338.1 - 1.7 8.8 5.0 6.3 7.0 0.0 3.2 3 0 0 3 3 3 0 von Willebrand factor type A domain TRP PF06011.12 KOO21339.1 - 6e-07 28.5 10.2 2.1e-06 26.8 6.4 2.9 2 1 1 3 3 3 1 Transient receptor potential (TRP) ion channel THOC2_N PF16134.5 KOO21339.1 - 0.19 10.3 0.0 0.3 9.7 0.0 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DUF4199 PF13858.6 KOO21339.1 - 0.6 10.5 0.0 0.6 10.5 0.0 4.1 3 1 0 3 3 3 0 Protein of unknown function (DUF4199) DUF4064 PF13273.6 KOO21339.1 - 3 8.2 0.0 3 8.2 0.0 4.1 4 1 2 6 6 6 0 Protein of unknown function (DUF4064) Asp PF00026.23 KOO21340.1 - 3.9e-57 194.1 0.0 5.1e-43 147.7 0.0 2.0 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO21340.1 - 1.7e-09 38.2 0.1 2.4e-08 34.4 0.1 2.1 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal RasGAP PF00616.19 KOO21341.1 - 2.7e-11 43.6 0.0 0.0002 21.2 0.0 2.5 2 1 0 2 2 2 2 GTPase-activator protein for Ras-like GTPase UBA PF00627.31 KOO21341.1 - 1.1e-06 28.4 0.0 6.5e-06 25.9 0.0 2.5 2 0 0 2 2 2 1 UBA/TS-N domain PDZ PF00595.24 KOO21341.1 - 4.5e-06 26.9 0.0 1.4e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PBP1_TM PF14812.6 KOO21341.1 - 1 9.8 8.4 2.6 8.5 8.4 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 KOO21341.1 - 1.8 7.8 4.5 3 7.1 4.5 1.2 1 0 0 1 1 1 0 NOA36 protein PNK3P PF08645.11 KOO21342.1 - 2e-26 92.6 0.0 2.5e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase zf-CCHH PF10283.9 KOO21342.1 - 1.1e-06 28.5 3.5 2.2e-06 27.5 3.5 1.5 1 0 0 1 1 1 1 PBZ domain Hydrolase_6 PF13344.6 KOO21342.1 - 0.07 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF3239 PF11580.8 KOO21342.1 - 0.091 13.1 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3239) TPR_10 PF13374.6 KOO21343.1 - 6.5e-58 191.2 19.0 3.4e-10 39.5 0.0 6.8 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21343.1 - 1.2e-48 163.2 14.8 2.1e-17 63.2 1.2 4.4 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21343.1 - 1.4e-20 72.1 2.5 0.0019 17.9 0.1 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21343.1 - 3.3e-17 61.1 10.0 0.0081 16.2 0.2 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO21343.1 - 7.8e-17 61.6 5.6 3.2e-11 43.2 0.9 3.3 1 1 1 2 2 2 2 MalT-like TPR region TPR_8 PF13181.6 KOO21343.1 - 8e-17 60.0 6.8 0.0065 16.6 0.0 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21343.1 - 1e-15 56.5 13.5 0.00054 19.8 0.0 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21343.1 - 7e-14 52.2 18.5 0.0017 18.9 0.7 6.1 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_4 PF07721.14 KOO21343.1 - 6.2e-09 35.6 7.8 0.38 11.5 0.2 7.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21343.1 - 1.6e-08 34.0 1.7 0.1 12.3 0.0 5.0 5 0 0 5 5 5 2 TPR repeat TPR_14 PF13428.6 KOO21343.1 - 7.5e-08 32.6 22.8 0.59 11.1 0.1 6.7 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO21343.1 - 3.6e-05 23.9 3.4 13 6.4 0.0 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21343.1 - 0.00012 22.5 15.9 0.43 11.1 1.8 4.5 2 2 2 4 4 4 4 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO21343.1 - 0.00044 20.4 10.9 6 7.2 0.2 6.7 7 0 0 7 7 7 1 Osmosensory transporter coiled coil TPR_3 PF07720.12 KOO21343.1 - 0.0033 17.4 0.0 13 5.9 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO21343.1 - 0.0042 17.3 0.3 7 7.0 0.1 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KOO21343.1 - 0.065 13.9 7.6 49 4.9 0.2 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TetR_C_18 PF17923.1 KOO21343.1 - 0.53 10.8 5.9 47 4.5 0.2 4.7 3 2 1 5 5 4 0 Tetracyclin repressor-like, C-terminal domain Lectin_N PF03954.14 KOO21343.1 - 0.81 9.4 5.6 5.6 6.7 0.2 3.3 3 1 0 3 3 3 0 Hepatic lectin, N-terminal domain TPR_5 PF12688.7 KOO21343.1 - 3.5 7.9 22.0 0.069 13.4 2.6 4.8 3 2 1 4 4 4 0 Tetratrico peptide repeat LRR_6 PF13516.6 KOO21344.1 - 0.014 15.4 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 Leucine Rich repeat ClpB_D2-small PF10431.9 KOO21345.1 - 0.052 13.6 0.1 13 6.0 0.0 2.3 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein TPR_12 PF13424.6 KOO21348.1 - 3.2e-27 94.6 2.4 4.9e-16 58.8 0.1 4.5 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO21348.1 - 1.7e-22 78.6 10.7 1.2e-08 34.6 0.0 4.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21348.1 - 8.4e-10 38.0 1.6 0.019 15.0 0.0 4.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21348.1 - 8.8e-09 34.8 0.2 0.011 15.5 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21348.1 - 2.2e-08 33.6 0.1 0.0019 18.1 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21348.1 - 0.0054 16.4 1.8 0.012 15.2 0.0 2.5 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.6 KOO21348.1 - 0.011 16.5 12.7 0.15 13.0 0.0 6.0 3 2 3 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21348.1 - 0.12 12.6 2.6 5.5 7.5 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3584 PF12128.8 KOO21348.1 - 0.2 9.1 11.5 0.27 8.7 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3138 PF11336.8 KOO21348.1 - 0.25 9.9 8.9 0.52 8.8 8.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Leu_zip PF15294.6 KOO21348.1 - 0.27 10.7 6.9 0.82 9.1 0.3 2.2 2 0 0 2 2 2 0 Leucine zipper CCDC144C PF14915.6 KOO21348.1 - 0.34 10.0 8.8 0.63 9.1 8.8 1.4 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region CSN5_C PF18323.1 KOO21348.1 - 0.83 10.6 9.1 2.6 9.0 0.8 2.7 3 0 0 3 3 2 0 Cop9 signalosome subunit 5 C-terminal domain COG2 PF06148.11 KOO21348.1 - 8.6 6.5 7.3 6.5 6.8 1.5 2.6 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Glyco_transf_34 PF05637.12 KOO21349.1 - 0.028 14.2 0.1 0.058 13.1 0.1 1.5 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family tRNA-synt_1 PF00133.22 KOO21349.1 - 0.049 11.9 0.2 0.071 11.3 0.2 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) PilX PF13681.6 KOO21349.1 - 0.061 13.7 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Type IV pilus assembly protein PilX C-term MHB PF16525.5 KOO21349.1 - 0.082 13.2 0.0 0.22 11.8 0.0 1.8 1 1 0 1 1 1 0 Haemophore, haem-binding Glyco_tranf_2_3 PF13641.6 KOO21350.1 - 4.7e-25 88.8 0.0 6.4e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 KOO21350.1 - 4.6e-19 69.1 16.4 1.1e-18 67.9 13.2 2.8 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 KOO21350.1 - 1.3e-09 37.8 0.0 2.7e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KOO21350.1 - 7.3e-07 29.2 0.0 1.1e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Chitin_synth_2 PF03142.15 KOO21350.1 - 4e-05 22.5 2.6 0.012 14.2 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase FSH1 PF03959.13 KOO21351.1 - 5.5e-13 49.1 0.0 7.8e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) 2OG-FeII_Oxy_3 PF13640.6 KOO21351.1 - 0.043 14.7 0.0 0.094 13.6 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF4148 PF13663.6 KOO21351.1 - 0.069 13.3 0.9 0.23 11.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Ion_trans PF00520.31 KOO21352.1 - 1e-21 77.3 4.7 1.5e-21 76.7 4.7 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO21352.1 - 5.6e-10 39.0 1.0 5.6e-10 39.0 1.0 2.2 2 0 0 2 2 2 1 Ion channel cNMP_binding PF00027.29 KOO21352.1 - 0.0046 17.0 0.0 0.014 15.4 0.0 1.8 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain ARL2_Bind_BART PF11527.8 KOO21353.1 - 4.4e-09 36.5 1.2 6e-09 36.0 1.2 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART DUF5442 PF17514.2 KOO21354.1 - 0.0077 16.4 0.1 0.01 16.0 0.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5442) RXT2_N PF08595.11 KOO21354.1 - 0.03 14.4 2.1 0.035 14.1 2.1 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal AA_permease_2 PF13520.6 KOO21355.1 - 2.9e-18 65.9 12.6 4e-18 65.5 12.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOO21355.1 - 3e-09 36.0 7.7 2.2e-06 26.6 8.2 2.0 2 0 0 2 2 2 2 Amino acid permease MASE2 PF05230.11 KOO21355.1 - 0.81 9.8 6.4 0.53 10.4 2.6 2.5 2 1 0 2 2 2 0 MASE2 domain Fmp27 PF10344.9 KOO21356.1 - 0.052 11.6 2.1 0.052 11.6 2.1 1.1 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 MDM10 PF12519.8 KOO21356.1 - 3.8 6.3 6.0 4.1 6.2 6.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 LRR_4 PF12799.7 KOO21357.1 - 6.3e-08 32.8 0.0 0.019 15.4 0.0 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO21357.1 - 1e-07 31.4 0.8 0.018 15.1 0.0 4.6 5 0 0 5 5 5 2 Leucine Rich repeat WW PF00397.26 KOO21357.1 - 1.2e-07 31.6 0.0 2.2e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 WW domain MMR_HSR1 PF01926.23 KOO21357.1 - 3.9e-06 26.9 0.0 9.1e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO21357.1 - 0.00082 19.3 0.0 0.002 18.1 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase LRR_8 PF13855.6 KOO21357.1 - 0.013 15.2 0.5 6.6 6.6 0.0 3.3 3 1 0 3 3 3 0 Leucine rich repeat IIGP PF05049.13 KOO21357.1 - 0.034 13.2 0.0 0.061 12.4 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Dynamin_N PF00350.23 KOO21357.1 - 0.046 13.8 0.2 0.19 11.8 0.1 1.9 2 1 0 3 3 3 0 Dynamin family AAA_23 PF13476.6 KOO21357.1 - 0.084 13.4 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KOO21357.1 - 0.1 12.3 0.1 0.91 9.2 0.1 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 KOO21357.1 - 0.12 12.9 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AIG1 PF04548.16 KOO21357.1 - 0.18 11.1 0.1 0.35 10.2 0.1 1.4 1 0 0 1 1 1 0 AIG1 family AAA_16 PF13191.6 KOO21357.1 - 0.37 11.2 0.0 0.37 11.2 0.0 2.8 3 1 0 3 3 3 0 AAA ATPase domain AAA_11 PF13086.6 KOO21358.1 - 4.9e-20 72.4 0.7 9.1e-09 35.5 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 KOO21358.1 - 2.5e-17 63.2 0.0 3.8e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain CSD PF00313.22 KOO21358.1 - 2.7e-05 23.9 0.0 4.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain AAA_30 PF13604.6 KOO21358.1 - 0.0001 22.1 1.1 0.0092 15.7 0.2 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOO21358.1 - 0.015 15.6 0.0 2.6 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KOO21358.1 - 0.058 13.7 0.1 8.5 6.7 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 KOO21358.1 - 0.17 11.5 2.5 0.73 9.4 0.2 2.6 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO21358.1 - 6.6 7.1 11.7 5.7 7.3 4.2 3.4 3 1 0 3 3 3 0 AAA ATPase domain CAP_N PF01213.19 KOO21358.1 - 6.9 6.0 6.9 17 4.7 6.9 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal FA_desaturase PF00487.24 KOO21360.1 - 3.1e-32 112.4 25.1 4.3e-32 111.9 25.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 KOO21360.1 - 2.2e-11 43.7 0.1 5.9e-11 42.4 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain TssR PF17643.1 KOO21360.1 - 0.093 10.7 0.0 0.13 10.2 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssR Cupin_8 PF13621.6 KOO21361.1 - 1.1e-41 143.2 0.0 2.3e-41 142.2 0.0 1.5 1 0 0 1 1 1 1 Cupin-like domain TPR_2 PF07719.17 KOO21361.1 - 1.9e-09 36.9 27.2 0.5 10.6 0.6 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21361.1 - 3.4e-08 33.1 5.3 0.014 15.1 0.7 5.3 5 0 0 5 5 5 2 TPR repeat TPR_1 PF00515.28 KOO21361.1 - 7.8e-08 31.8 10.5 0.035 14.0 0.5 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21361.1 - 0.00056 19.9 1.0 6.2 7.3 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO21361.1 - 0.0031 17.8 1.3 0.21 12.0 0.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21361.1 - 0.0096 16.2 4.0 0.0096 16.2 4.0 5.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21361.1 - 0.021 15.5 2.3 0.021 15.5 2.3 6.1 4 2 0 4 4 4 0 Tetratricopeptide repeat JmjC PF02373.22 KOO21361.1 - 0.03 14.8 0.0 0.066 13.6 0.0 1.6 1 0 0 1 1 1 0 JmjC domain, hydroxylase Alginate_exp PF13372.6 KOO21361.1 - 0.055 12.2 0.0 0.091 11.5 0.0 1.3 1 0 0 1 1 1 0 Alginate export Cupin_4 PF08007.12 KOO21361.1 - 0.083 12.3 0.0 0.8 9.1 0.0 2.3 2 0 0 2 2 2 0 Cupin superfamily protein TPR_7 PF13176.6 KOO21361.1 - 3.5 7.9 17.8 0.24 11.5 0.3 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat ABC_tran PF00005.27 KOO21362.1 - 2.2e-46 157.8 0.0 1.8e-28 99.7 0.0 2.7 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KOO21362.1 - 1.6e-21 77.2 4.9 2.9e-21 76.3 4.9 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 KOO21362.1 - 1.5e-05 24.5 3.0 0.03 13.8 0.0 4.1 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO21362.1 - 1.8e-05 25.2 4.4 0.045 14.1 0.2 3.4 4 0 0 4 4 3 2 AAA ATPase domain AAA_29 PF13555.6 KOO21362.1 - 1.9e-05 24.3 4.5 0.04 13.7 0.1 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_24 PF13479.6 KOO21362.1 - 5.5e-05 23.0 0.0 0.14 11.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 KOO21362.1 - 8.5e-05 22.8 1.2 0.17 12.0 0.1 2.7 3 0 0 3 3 2 2 Helicase HerA, central domain Zeta_toxin PF06414.12 KOO21362.1 - 0.0002 20.7 1.6 0.34 10.2 0.0 3.1 3 0 0 3 3 3 2 Zeta toxin AAA_25 PF13481.6 KOO21362.1 - 0.00024 20.8 1.6 0.55 9.8 0.6 2.9 3 1 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 KOO21362.1 - 0.00055 20.0 0.3 0.32 11.1 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KOO21362.1 - 0.00078 19.7 0.9 5.6 7.2 0.4 3.5 3 1 0 3 3 3 0 AAA domain AAA_18 PF13238.6 KOO21362.1 - 0.00094 19.7 0.5 1.7 9.2 0.1 2.5 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 KOO21362.1 - 0.0015 17.6 0.4 0.23 10.4 0.1 2.4 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 KOO21362.1 - 0.0033 17.3 1.3 1.3 8.9 0.2 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 KOO21362.1 - 0.0085 16.3 3.1 2.5 8.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 KOO21362.1 - 0.0086 15.3 1.2 3.4 6.8 0.1 2.8 3 0 0 3 3 3 1 NB-ARC domain APS_kinase PF01583.20 KOO21362.1 - 0.0097 15.8 0.6 5.1 7.0 0.1 2.5 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_17 PF13207.6 KOO21362.1 - 0.015 15.7 2.6 3.6 8.0 1.4 3.5 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KOO21362.1 - 0.019 14.9 0.2 2.2 8.2 0.1 2.5 2 0 0 2 2 2 0 NTPase FtsK_SpoIIIE PF01580.18 KOO21362.1 - 0.021 14.2 0.1 6.7 6.0 0.0 2.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_5 PF07728.14 KOO21362.1 - 0.031 14.3 0.6 20 5.2 0.1 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 KOO21362.1 - 0.032 14.1 0.8 6.1 6.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system PRK PF00485.18 KOO21362.1 - 0.048 13.4 0.2 6.4 6.5 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ATP-synt_ab PF00006.25 KOO21362.1 - 0.049 13.3 0.1 11 5.6 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain IstB_IS21 PF01695.17 KOO21362.1 - 0.051 13.3 0.0 3.1 7.5 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein CbiA PF01656.23 KOO21362.1 - 0.072 13.1 0.3 13 5.8 0.0 2.5 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 KOO21362.1 - 0.076 12.8 0.8 3.5 7.3 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF2809 PF10990.8 KOO21362.1 - 0.081 13.6 0.0 0.36 11.5 0.0 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF2809) Roc PF08477.13 KOO21362.1 - 0.091 13.0 0.3 3.5 7.9 0.1 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 KOO21362.1 - 0.13 12.1 1.6 17 5.3 0.1 2.6 2 0 0 2 2 2 0 NACHT domain SbcCD_C PF13558.6 KOO21362.1 - 0.15 12.3 0.6 0.89 9.8 0.6 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF815 PF05673.13 KOO21362.1 - 0.16 11.1 0.6 19 4.3 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 KOO21362.1 - 0.16 11.4 0.0 16 5.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region MoaE PF02391.17 KOO21362.1 - 0.33 11.2 2.3 6.3 7.1 0.1 2.7 2 0 0 2 2 2 0 MoaE protein AAA_28 PF13521.6 KOO21362.1 - 2.2 8.5 8.0 21 5.3 1.1 3.7 3 2 1 4 4 4 0 AAA domain Wbp11 PF09429.10 KOO21363.1 - 0.014 15.8 0.1 0.026 14.9 0.1 1.4 1 0 0 1 1 1 0 WW domain binding protein 11 MRP-L47 PF06984.13 KOO21364.1 - 5.2e-21 74.6 0.4 8.9e-21 73.8 0.4 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 KOO21364.1 - 5.2e-07 29.5 2.8 1e-06 28.6 2.8 1.5 1 0 0 1 1 1 1 Ribosomal L29 protein TarH PF02203.15 KOO21364.1 - 0.054 13.4 0.4 0.054 13.4 0.4 1.6 2 0 0 2 2 2 0 Tar ligand binding domain homologue CIA30 PF08547.12 KOO21365.1 - 1.1e-19 71.1 0.0 1.5e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Adaptin_N PF01602.20 KOO21367.1 - 3.5e-87 293.1 0.0 4.6e-87 292.7 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KOO21367.1 - 1.9e-18 67.1 0.1 2.7e-15 56.8 0.0 2.9 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOO21367.1 - 1.3e-08 35.1 2.2 0.00025 21.4 0.1 6.0 3 1 5 8 8 8 4 HEAT repeats RTP1_C1 PF10363.9 KOO21367.1 - 1.2e-05 25.5 0.5 0.08 13.1 0.0 3.4 4 0 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 KOO21367.1 - 4.2e-05 24.0 20.3 0.085 13.4 0.1 6.3 7 0 0 7 7 7 2 HEAT-like repeat HEAT PF02985.22 KOO21367.1 - 0.00045 20.2 14.4 0.44 10.9 0.1 6.2 7 0 0 7 7 7 3 HEAT repeat DUF3384 PF11864.8 KOO21367.1 - 0.0011 17.9 1.1 0.0017 17.3 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) DUF5578 PF17741.1 KOO21367.1 - 0.0049 16.3 2.7 0.58 9.5 0.5 3.2 1 1 3 4 4 4 1 Family of unknown function (DUF5578) XPC-binding PF09280.11 KOO21367.1 - 0.099 12.4 0.1 17 5.2 0.0 3.6 3 0 0 3 3 3 0 XPC-binding domain Filamin PF00630.19 KOO21368.1 - 6e-44 149.1 0.0 2.1e-12 47.8 0.0 7.1 7 0 0 7 7 7 5 Filamin/ABP280 repeat C2 PF00168.30 KOO21368.1 - 7.7e-15 55.0 0.0 1.8e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain CAP_GLY PF01302.25 KOO21368.1 - 3.5e-14 52.6 0.4 6.9e-14 51.6 0.4 1.5 1 0 0 1 1 1 1 CAP-Gly domain Invasin_D3 PF09134.10 KOO21368.1 - 1.1e-11 44.9 0.0 0.03 14.6 0.0 4.2 4 0 0 4 4 4 3 Invasin, domain 3 Big_1 PF02369.16 KOO21368.1 - 0.0015 18.5 0.0 0.016 15.2 0.0 2.9 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 1) Y_Y_Y PF07495.13 KOO21368.1 - 0.017 15.1 0.0 1.2 9.1 0.0 2.7 3 0 0 3 3 3 0 Y_Y_Y domain FixH PF05751.11 KOO21368.1 - 0.061 13.3 0.0 3.5 7.6 0.0 3.0 3 0 0 3 3 3 0 FixH EF-hand_8 PF13833.6 KOO21369.1 - 4.3e-12 45.7 1.0 2.6e-06 27.2 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21369.1 - 2.8e-10 39.3 3.0 0.01 15.7 0.3 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO21369.1 - 2e-09 36.3 2.7 0.042 13.4 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO21369.1 - 2.1e-09 37.7 2.5 2.7e-05 24.5 0.2 2.8 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO21369.1 - 0.00081 18.8 3.0 3.8 7.2 0.1 3.6 3 0 0 3 3 3 2 EF hand p25-alpha PF05517.12 KOO21369.1 - 0.045 13.9 0.5 0.39 10.9 0.2 2.3 2 0 0 2 2 2 0 p25-alpha Armet PF10208.9 KOO21369.1 - 0.051 13.5 0.2 1.9 8.4 0.1 2.4 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding DDE_Tnp_1_2 PF13586.6 KOO21369.1 - 0.083 13.3 0.1 0.56 10.6 0.1 2.3 2 0 0 2 2 2 0 Transposase DDE domain Bact_lectin PF18483.1 KOO21369.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial lectin Med9 PF07544.13 KOO21369.1 - 0.19 11.9 2.9 0.57 10.3 0.1 2.8 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 EspA PF03433.13 KOO21369.1 - 0.22 11.3 5.1 4.1 7.2 0.1 3.4 2 1 1 3 3 3 0 EspA-like secreted protein Ion_trans PF00520.31 KOO21370.1 - 4e-18 65.5 4.7 6.8e-18 64.8 4.7 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO21370.1 - 6.6e-06 26.0 7.2 6.6e-06 26.0 7.2 2.1 2 0 0 2 2 2 1 Ion channel EF-hand_6 PF13405.6 KOO21372.1 - 3.7e-11 42.0 0.0 0.00018 21.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO21372.1 - 4e-11 41.6 0.0 0.00041 19.7 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21372.1 - 4.6e-08 32.8 0.0 0.0041 16.9 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO21372.1 - 2.9e-07 29.7 0.0 0.0003 20.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO21372.1 - 3.8e-07 30.5 0.0 1.3e-06 28.7 0.0 1.9 1 1 0 1 1 1 1 EF-hand domain pair Sel1 PF08238.12 KOO21372.1 - 0.00038 21.0 4.5 1.5 9.7 0.1 5.1 5 0 0 5 5 5 1 Sel1 repeat Fis1_TPR_N PF14852.6 KOO21372.1 - 0.024 14.3 0.1 0.05 13.3 0.1 1.5 1 0 0 1 1 1 0 Fis1 N-terminal tetratricopeptide repeat EF-hand_10 PF14788.6 KOO21372.1 - 0.069 13.0 0.1 0.24 11.3 0.1 1.9 2 0 0 2 2 2 0 EF hand ASH PF15780.5 KOO21374.1 - 2.4e-06 27.6 0.0 0.0011 19.1 0.0 2.3 2 0 0 2 2 2 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 KOO21374.1 - 0.00012 22.1 0.0 0.0029 17.7 0.0 2.6 3 0 0 3 3 3 1 Flagellar-associated PapD-like Paf67 PF10255.9 KOO21375.1 - 7e-152 506.1 0.0 9.7e-152 505.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 KOO21375.1 - 0.057 13.6 0.0 0.23 11.6 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat NusB PF01029.18 KOO21375.1 - 0.068 13.4 0.3 0.2 11.9 0.0 1.9 2 0 0 2 2 2 0 NusB family TPR_1 PF00515.28 KOO21375.1 - 0.11 12.4 0.1 0.3 11.0 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat MscS_porin PF12795.7 KOO21375.1 - 0.11 12.0 0.1 0.32 10.5 0.0 1.8 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Pkinase PF00069.25 KOO21376.1 - 3.5e-47 161.0 0.0 1.9e-46 158.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21376.1 - 3.9e-20 72.2 0.0 5.8e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ATP-synt_Eps PF04627.13 KOO21376.1 - 2.2e-18 66.0 0.3 4.1e-18 65.1 0.3 1.5 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Kinase-like PF14531.6 KOO21376.1 - 0.0015 17.9 0.0 0.0025 17.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO21376.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOO21376.1 - 0.11 12.1 0.0 12 5.4 0.0 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 KOO21376.1 - 0.13 11.0 0.0 0.26 10.0 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase EF-hand_6 PF13405.6 KOO21378.1 - 8.9e-09 34.6 0.1 0.0023 17.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO21378.1 - 1.9e-08 34.6 0.4 3.6e-08 33.8 0.4 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO21378.1 - 6e-08 31.7 0.5 0.004 16.6 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21378.1 - 0.0017 18.2 0.6 0.0054 16.6 0.2 1.9 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO21378.1 - 0.013 15.0 0.2 2.9 7.5 0.1 2.3 2 0 0 2 2 2 0 EF hand AAA_25 PF13481.6 KOO21378.1 - 0.019 14.6 0.2 0.022 14.3 0.2 1.1 1 0 0 1 1 1 0 AAA domain EF-hand_11 PF08976.11 KOO21378.1 - 0.025 15.4 0.1 0.033 15.1 0.1 1.1 1 0 0 1 1 1 0 EF-hand domain TylF PF05711.11 KOO21379.1 - 0.00098 18.5 0.0 0.002 17.4 0.0 1.4 1 1 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 KOO21379.1 - 0.056 14.5 0.0 0.12 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain TP2 PF01254.18 KOO21379.1 - 0.075 13.6 8.0 0.12 12.9 8.0 1.3 1 0 0 1 1 1 0 Nuclear transition protein 2 CS PF04969.16 KOO21380.1 - 2.5e-08 34.8 0.0 4.9e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 CS domain Myb_DNA-binding PF00249.31 KOO21381.1 - 1.4e-13 50.8 0.0 2.2e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO21381.1 - 5.7e-07 29.7 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO21381.1 - 0.0021 17.9 1.2 0.0023 17.8 0.0 1.6 2 0 0 2 2 2 1 Myb DNA-binding like Alveol-reg_P311 PF11092.8 KOO21381.1 - 0.04 14.1 0.1 0.13 12.5 0.1 1.9 1 0 0 1 1 1 0 Neuronal protein 3.1 (p311) SLIDE PF09111.10 KOO21381.1 - 0.22 11.5 0.0 0.4 10.7 0.0 1.3 1 0 0 1 1 1 0 SLIDE RR_TM4-6 PF06459.12 KOO21381.1 - 5.6 6.7 5.4 9.3 6.0 5.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TB2_DP1_HVA22 PF03134.19 KOO21382.1 - 2.7e-22 78.5 6.4 4.3e-22 77.8 6.4 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Arb2 PF09757.9 KOO21382.1 - 0.068 12.3 0.3 0.11 11.6 0.1 1.3 1 1 0 1 1 1 0 Arb2 domain EF-hand_6 PF13405.6 KOO21384.1 - 0.00098 18.9 0.0 0.0031 17.3 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO21384.1 - 0.023 14.2 0.0 0.065 12.8 0.0 1.8 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.6 KOO21384.1 - 0.034 13.7 0.0 0.076 12.5 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO21384.1 - 0.083 13.3 0.0 0.28 11.7 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair MotA_ExbB PF01618.16 KOO21384.1 - 0.089 12.5 0.4 0.5 10.1 0.4 2.3 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family Exo_endo_phos PF03372.23 KOO21386.1 - 6.7e-06 25.8 0.0 8e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TPR_1 PF00515.28 KOO21387.1 - 3.9e-08 32.8 2.4 1e-05 25.1 0.5 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21387.1 - 5.9e-08 32.2 5.3 9.9e-06 25.3 0.8 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21387.1 - 0.00018 22.1 3.0 0.00018 22.1 3.0 4.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21387.1 - 0.0034 17.6 9.6 0.0041 17.4 3.3 3.3 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO21387.1 - 0.0038 17.3 2.0 0.0038 17.3 2.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-CXXC PF02008.20 KOO21387.1 - 0.012 15.7 15.7 0.026 14.5 15.7 1.5 1 0 0 1 1 1 0 CXXC zinc finger domain DUF5588 PF17826.1 KOO21387.1 - 0.014 14.3 0.1 0.023 13.6 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5588) TPR_8 PF13181.6 KOO21387.1 - 0.015 15.5 1.7 0.048 13.9 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21387.1 - 0.031 14.8 1.9 0.031 14.8 1.9 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5113 PF17140.4 KOO21387.1 - 0.045 13.6 3.4 0.12 12.2 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) Exo_endo_phos PF03372.23 KOO21389.1 - 1.4e-10 41.1 0.3 2.3e-10 40.4 0.3 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ACT PF01842.25 KOO21390.1 - 1.3e-14 53.7 2.4 1.9e-07 30.7 0.1 2.4 2 0 0 2 2 2 2 ACT domain ACT_4 PF13291.6 KOO21390.1 - 8.6e-08 32.7 0.5 0.0087 16.6 0.0 2.4 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 KOO21390.1 - 0.00058 19.6 0.3 0.46 10.3 0.0 2.6 2 0 0 2 2 2 2 ACT domain ACT_6 PF13740.6 KOO21390.1 - 0.018 15.0 0.7 0.48 10.4 0.0 2.4 2 0 0 2 2 2 0 ACT domain UvrD-helicase PF00580.21 KOO21390.1 - 0.022 14.3 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Pkinase PF00069.25 KOO21391.1 - 5.3e-70 235.8 0.0 5.1e-68 229.3 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21391.1 - 3.3e-35 121.6 0.0 1.6e-33 116.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO21391.1 - 6.2e-06 25.7 0.0 6.8e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO21391.1 - 0.0003 20.2 0.0 0.00053 19.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family UBA_2 PF08587.11 KOO21392.1 - 0.0036 17.4 1.8 0.12 12.6 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin associated domain (UBA) DUF2795 PF11387.8 KOO21392.1 - 0.039 14.1 1.6 1.6 9.0 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2795) Ribosomal_L10 PF00466.20 KOO21392.1 - 1.7 8.8 5.3 9.7 6.4 0.1 2.8 1 1 2 3 3 3 0 Ribosomal protein L10 DUF4413 PF14372.6 KOO21393.1 - 0.01 16.2 0.1 0.017 15.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) G6B PF15096.6 KOO21393.1 - 0.17 11.6 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 G6B family 3HCDH_N PF02737.18 KOO21394.1 - 4.1e-25 88.7 0.0 5.4e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-C3HC4_3 PF13920.6 KOO21394.1 - 2.7e-14 52.8 6.5 5.3e-14 51.8 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO21394.1 - 2.9e-05 23.9 5.0 3.1e-05 23.7 3.0 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO21394.1 - 3.6e-05 24.0 7.9 0.00012 22.3 7.9 2.0 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KOO21394.1 - 6.9e-05 22.6 8.2 0.00015 21.5 8.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOO21394.1 - 0.00035 20.5 4.9 0.00085 19.2 4.9 1.7 1 0 0 1 1 1 1 zinc-RING finger domain AAA_7 PF12775.7 KOO21394.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region zf-C3HC4_2 PF13923.6 KOO21394.1 - 0.04 13.8 7.1 0.17 11.7 7.1 2.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) NAD_binding_2 PF03446.15 KOO21394.1 - 0.049 13.8 0.0 0.095 12.9 0.0 1.4 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase adh_short_C2 PF13561.6 KOO21394.1 - 0.17 11.4 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase zf-C4H2 PF10146.9 KOO21394.1 - 0.78 10.0 3.2 1.9 8.8 3.2 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein GHMP_kinases_N PF00288.26 KOO21395.1 - 3.8e-10 39.9 0.2 1.9e-09 37.6 0.0 2.3 2 0 0 2 2 2 1 GHMP kinases N terminal domain NTP_transferase PF00483.23 KOO21395.1 - 6.9e-07 29.1 0.0 4.3e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyl transferase GalKase_gal_bdg PF10509.9 KOO21395.1 - 0.011 15.3 0.1 0.045 13.3 0.0 2.0 2 0 0 2 2 2 0 Galactokinase galactose-binding signature Spc7 PF08317.11 KOO21397.1 - 0.0058 15.6 12.0 0.0061 15.5 12.0 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein YkyA PF10368.9 KOO21397.1 - 0.019 14.6 4.4 0.023 14.4 4.4 1.2 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Harakiri PF15196.6 KOO21397.1 - 0.088 13.3 2.0 2.4 8.7 0.2 2.2 2 0 0 2 2 2 0 Activator of apoptosis harakiri Phage_GP20 PF06810.11 KOO21397.1 - 0.29 10.9 5.4 0.14 11.9 1.3 2.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF16 PF01519.16 KOO21397.1 - 0.42 11.1 8.4 7.1 7.2 8.3 2.1 1 1 0 1 1 1 0 Protein of unknown function DUF16 Viral_P18 PF04521.13 KOO21397.1 - 1.1 9.1 8.3 2 8.2 1.0 2.2 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein MCU PF04678.13 KOO21397.1 - 2 8.5 5.2 1 9.4 3.4 1.4 1 1 0 1 1 1 0 Mitochondrial calcium uniporter YabA PF06156.13 KOO21397.1 - 4.2 8.1 10.2 1.1 9.9 1.0 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Fzo_mitofusin PF04799.13 KOO21397.1 - 4.4 6.8 9.9 3.1 7.3 2.8 2.0 1 1 1 2 2 2 0 fzo-like conserved region DUF501 PF04417.12 KOO21397.1 - 7.3 6.4 9.0 2.1 8.2 2.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF501) Leu_zip PF15294.6 KOO21398.1 - 2.3e-29 102.8 5.4 2.3e-29 102.8 5.4 1.8 2 0 0 2 2 2 1 Leucine zipper LRR_6 PF13516.6 KOO21398.1 - 5.1e-09 35.5 0.8 0.0013 18.6 0.0 4.0 3 0 0 3 3 3 3 Leucine Rich repeat HALZ PF02183.18 KOO21398.1 - 0.029 14.6 3.0 1.9 8.8 0.1 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper THOC7 PF05615.13 KOO21398.1 - 0.033 14.5 16.1 0.13 12.6 1.8 3.4 3 0 0 3 3 3 0 Tho complex subunit 7 CDC73_N PF16050.5 KOO21398.1 - 0.14 11.5 1.7 0.28 10.5 1.7 1.6 1 0 0 1 1 1 0 Paf1 complex subunit CDC73 N-terminal ALMT PF11744.8 KOO21398.1 - 0.14 10.9 2.0 0.3 9.9 2.0 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter LRR_4 PF12799.7 KOO21398.1 - 0.16 12.4 0.7 62 4.2 0.3 3.3 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) Seryl_tRNA_N PF02403.22 KOO21398.1 - 0.23 11.7 11.3 0.045 14.0 2.8 3.0 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 KOO21398.1 - 0.63 9.3 15.3 0.074 12.4 10.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 KOO21398.1 - 0.68 8.8 10.8 0.34 9.7 4.5 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein HAUS6_N PF14661.6 KOO21398.1 - 0.8 9.2 13.1 0.66 9.5 10.6 2.2 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Bap31_Bap29_C PF18035.1 KOO21398.1 - 0.92 9.6 6.8 0.22 11.6 2.3 2.3 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Syntaxin_2 PF14523.6 KOO21398.1 - 0.96 9.9 6.7 0.15 12.5 1.8 2.1 2 0 0 2 2 2 0 Syntaxin-like protein HAUS-augmin3 PF14932.6 KOO21398.1 - 2 7.9 12.9 0.14 11.7 6.6 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 YabA PF06156.13 KOO21398.1 - 2.3 8.9 6.5 1.4 9.6 2.1 2.6 1 1 1 2 2 2 0 Initiation control protein YabA Ubie_methyltran PF01209.18 KOO21399.1 - 1.6e-06 27.6 0.0 1.6e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 KOO21399.1 - 2.4e-06 28.1 0.0 2.7e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO21399.1 - 3.1e-06 27.1 0.0 3.1e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO21399.1 - 3.8e-05 24.3 0.0 5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO21399.1 - 6.4e-05 23.6 0.0 7.4e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO21399.1 - 0.00024 21.0 0.0 0.00025 20.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 KOO21399.1 - 0.1 12.6 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Brix PF04427.18 KOO21402.1 - 5.6e-35 121.2 0.0 7.4e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Brix domain TTL PF03133.15 KOO21403.1 - 1.5e-75 254.1 0.0 2e-75 253.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO21403.1 - 4.3e-05 22.9 0.0 0.11 11.7 0.0 2.6 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO21403.1 - 0.00012 21.4 0.0 0.056 12.7 0.0 2.5 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 KOO21403.1 - 0.0063 16.6 0.0 0.023 14.8 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain Mg_trans_NIPA PF05653.14 KOO21406.1 - 8.6e-18 64.5 9.4 2e-17 63.3 9.4 1.5 1 1 0 1 1 1 1 Magnesium transporter NIPA Phage_r1t_holin PF16945.5 KOO21406.1 - 0.22 11.7 0.2 0.22 11.7 0.2 2.2 2 1 0 2 2 2 0 Putative lactococcus lactis phage r1t holin DUF2781 PF10914.8 KOO21406.1 - 0.59 10.5 5.6 0.22 11.9 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2781) VRR_NUC PF08774.11 KOO21407.1 - 1.4e-05 25.1 0.0 1.9e-05 24.7 0.0 1.3 1 1 0 1 1 1 1 VRR-NUC domain EF-hand_5 PF13202.6 KOO21408.1 - 3.6e-05 23.0 0.2 6.1e-05 22.3 0.2 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO21408.1 - 5.2e-05 22.5 1.3 7e-05 22.1 0.4 1.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO21408.1 - 0.00048 19.8 1.5 0.00066 19.4 0.6 1.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 KOO21408.1 - 0.0019 18.0 0.2 0.0032 17.3 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 KOO21408.1 - 0.014 15.8 0.0 0.023 15.2 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair TPR_10 PF13374.6 KOO21409.1 - 2.7e-82 268.7 38.7 3.7e-12 45.7 0.6 9.7 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21409.1 - 1.4e-72 240.0 46.4 7.4e-17 61.4 4.2 6.2 2 2 5 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21409.1 - 1.3e-28 97.6 11.5 0.0015 18.3 0.0 8.6 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21409.1 - 4.6e-26 88.8 8.3 0.01 16.0 0.0 9.2 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO21409.1 - 5.7e-24 85.1 20.3 3.6e-12 46.3 7.1 3.5 1 1 2 3 3 3 3 MalT-like TPR region TPR_2 PF07719.17 KOO21409.1 - 5.5e-23 79.2 19.5 0.0037 17.2 0.5 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_4 PF07721.14 KOO21409.1 - 4.2e-16 57.8 38.0 0.099 13.3 0.1 11.7 11 0 0 11 11 10 6 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21409.1 - 2.1e-13 49.3 36.4 0.045 13.8 0.0 9.3 11 0 0 11 11 8 6 Tetratricopeptide repeat TPR_17 PF13431.6 KOO21409.1 - 2.4e-13 49.4 8.1 2 9.0 0.0 8.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21409.1 - 2.8e-10 40.7 46.9 6.7e-07 29.8 3.6 8.5 5 4 2 7 7 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21409.1 - 2.7e-06 27.8 40.7 0.00061 20.2 2.6 6.7 4 2 4 8 8 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21409.1 - 5.9e-06 25.9 11.9 0.1 12.3 0.3 7.2 8 0 0 8 8 8 2 TPR repeat TPR_3 PF07720.12 KOO21409.1 - 6.5e-06 26.0 0.0 39 4.4 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Prok-TraM PF09228.10 KOO21409.1 - 0.012 15.9 0.5 0.082 13.3 0.2 2.4 2 0 0 2 2 2 0 Prokaryotic Transcriptional repressor TraM Osmo_CC PF08946.10 KOO21409.1 - 0.015 15.5 17.3 11 6.3 0.0 7.1 7 0 0 7 7 7 0 Osmosensory transporter coiled coil TPR_14 PF13428.6 KOO21409.1 - 0.046 14.5 50.8 3.3 8.8 0.1 10.0 11 0 0 11 11 8 0 Tetratricopeptide repeat zf-Nse PF11789.8 KOO21410.1 - 0.00014 21.6 2.6 0.00044 20.0 2.6 1.8 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 KOO21410.1 - 0.33 10.7 4.5 0.46 10.3 3.8 1.7 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger NDC10_II PF16787.5 KOO21413.1 - 1.6e-13 50.4 0.0 3.2e-13 49.4 0.0 1.4 2 0 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 KOO21413.1 - 3.6e-05 24.0 0.0 6.6e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Clp_N PF02861.20 KOO21413.1 - 0.12 12.6 0.1 0.64 10.2 0.0 2.3 2 0 0 2 2 2 0 Clp amino terminal domain, pathogenicity island component ABC1 PF03109.16 KOO21415.1 - 6e-26 91.0 0.0 1.1e-25 90.1 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO21415.1 - 5.7e-05 23.1 0.1 0.00015 21.8 0.1 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO21415.1 - 0.0035 16.8 0.0 0.0063 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF2587 PF10759.9 KOO21415.1 - 0.11 12.0 0.1 0.43 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2587) AGTRAP PF06396.11 KOO21416.1 - 0.016 15.0 0.7 0.023 14.5 0.3 1.4 1 1 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) SafA PF17073.5 KOO21416.1 - 0.073 13.0 1.0 0.22 11.5 0.1 2.1 2 0 0 2 2 2 0 Two-component-system connector protein RHH_4 PF13467.6 KOO21416.1 - 0.092 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Ribbon-helix-helix domain CitMHS PF03600.16 KOO21417.1 - 5.2e-29 101.4 22.5 5.2e-29 101.4 22.5 2.1 2 0 0 2 2 2 1 Citrate transporter PDZ PF00595.24 KOO21419.1 - 1.4e-09 38.2 0.0 2.4e-09 37.4 0.0 1.5 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KOO21419.1 - 5.4e-09 35.8 0.0 7.6e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO21419.1 - 3.3e-06 27.3 0.0 4e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 PDZ domain LRR_5 PF13306.6 KOO21420.1 - 2.3e-92 305.6 0.1 5.5e-34 116.9 0.2 3.0 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO21420.1 - 3.6e-20 71.5 0.0 0.00058 19.6 0.0 7.2 1 1 8 9 9 9 7 Leucine rich repeat DUF717 PF05338.12 KOO21420.1 - 0.014 15.5 0.0 7.7 6.7 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF717) Forkhead_N PF08430.12 KOO21420.1 - 0.16 12.6 19.9 1.3 9.6 5.2 3.4 1 1 2 3 3 3 0 Forkhead N-terminal region LRR_4 PF12799.7 KOO21420.1 - 0.36 11.3 3.1 1.1e+02 3.4 0.0 5.2 5 2 2 7 7 7 0 Leucine Rich repeats (2 copies) Sulfatase PF00884.23 KOO21421.1 - 1.7e-34 119.6 0.0 2.4e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 KOO21421.1 - 0.024 14.2 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4994 PF16385.5 KOO21421.1 - 0.047 13.6 0.0 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function AAA PF00004.29 KOO21425.1 - 1.2e-14 54.9 0.0 2.8e-14 53.6 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BAH PF01426.18 KOO21425.1 - 2.4e-14 53.2 0.0 3.8e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 BAH domain AAA_16 PF13191.6 KOO21425.1 - 5.3e-12 46.4 1.7 6.4e-12 46.2 0.2 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOO21425.1 - 7.1e-10 39.3 0.0 1.7e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_lid_10 PF17872.1 KOO21425.1 - 4.5e-07 29.9 0.2 8.7e-07 29.0 0.2 1.4 1 0 0 1 1 1 1 AAA lid domain NACHT PF05729.12 KOO21425.1 - 0.0008 19.4 0.0 0.0017 18.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 KOO21425.1 - 0.0011 19.3 0.1 0.0047 17.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 KOO21425.1 - 0.0054 16.7 0.0 0.01 15.8 0.0 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 KOO21425.1 - 0.01 15.6 0.1 0.028 14.2 0.1 1.7 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO21425.1 - 0.057 12.7 0.0 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 KOO21425.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_32 PF13654.6 KOO21425.1 - 0.12 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOO21425.1 - 0.15 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KOO21425.1 - 0.18 11.7 0.1 0.39 10.6 0.1 1.8 1 1 0 1 1 1 0 NTPase Rad17 PF03215.15 KOO21425.1 - 0.18 11.7 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ABM PF03992.16 KOO21427.1 - 6.4e-16 58.2 0.2 5.2e-07 29.7 0.1 2.2 2 0 0 2 2 2 2 Antibiotic biosynthesis monooxygenase MucBP PF06458.12 KOO21427.1 - 0.11 13.5 0.0 0.26 12.3 0.0 1.6 2 0 0 2 2 2 0 MucBP domain CRAL_TRIO PF00650.20 KOO21428.1 - 4.1e-08 33.1 0.0 6.4e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain DUF737 PF05300.11 KOO21429.1 - 1.9 8.8 9.0 0.41 11.0 5.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF737) Ank_2 PF12796.7 KOO21430.1 - 8.4e-37 125.6 11.0 7.4e-13 48.9 0.1 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO21430.1 - 4.8e-18 65.3 0.6 2.5e-06 27.9 0.0 4.1 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO21430.1 - 2.1e-15 56.6 6.3 2.9e-05 24.2 0.2 4.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO21430.1 - 2e-14 53.3 13.3 0.00062 20.1 0.1 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KOO21430.1 - 6.1e-11 41.5 4.4 0.2 12.3 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat zf-C3HC4_3 PF13920.6 KOO21430.1 - 8.4e-11 41.6 8.3 1.6e-10 40.7 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO21430.1 - 0.0017 18.2 10.3 0.0031 17.3 10.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOO21430.1 - 0.066 13.6 10.8 0.13 12.6 10.8 1.6 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 KOO21430.1 - 0.95 9.5 10.7 2.7 8.0 10.8 1.8 1 1 0 1 1 1 0 zinc-RING finger domain GST_N_5 PF18485.1 KOO21430.1 - 1.6 9.1 6.7 24 5.4 0.3 3.9 3 1 0 3 3 3 0 Glutathione S-transferase, N-terminal domain SURF4 PF02077.15 KOO21431.1 - 1.3e-31 110.2 4.6 1.8e-31 109.8 4.6 1.1 1 0 0 1 1 1 1 SURF4 family Ank_2 PF12796.7 KOO21432.1 - 1e-15 58.0 0.1 7.2e-08 32.9 0.0 2.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO21432.1 - 2.4e-10 40.7 0.2 6.7e-07 29.7 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO21432.1 - 3.4e-08 33.6 0.3 0.00076 19.7 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO21432.1 - 2.4e-06 27.4 0.1 0.018 15.5 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KOO21432.1 - 2.5e-06 27.7 3.9 0.0013 19.1 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Stanniocalcin PF03298.13 KOO21432.1 - 0.032 13.5 0.1 0.084 12.2 0.1 1.7 1 0 0 1 1 1 0 Stanniocalcin family zf-RING_5 PF14634.6 KOO21432.1 - 0.056 13.4 0.5 0.13 12.3 0.5 1.5 1 0 0 1 1 1 0 zinc-RING finger domain ParcG PF10274.9 KOO21433.1 - 1.9e-33 116.1 0.0 6.3e-28 98.1 0.0 2.6 2 0 0 2 2 2 2 Parkin co-regulated protein Ribosomal_L29 PF00831.23 KOO21433.1 - 6.6e-20 70.8 3.4 6.6e-20 70.8 3.4 3.1 3 0 0 3 3 3 1 Ribosomal L29 protein HLH PF00010.26 KOO21433.1 - 0.058 13.4 2.3 1.5 8.8 0.3 2.5 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain DUF4208 PF13907.6 KOO21433.1 - 1.5 9.3 5.9 2 8.9 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) Peptidase_M14 PF00246.24 KOO21434.1 - 8.4e-16 58.6 0.0 1.3e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 KOO21434.1 - 5.9e-13 49.1 0.0 9.5e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain AstE_AspA PF04952.14 KOO21434.1 - 0.015 14.4 0.1 0.022 13.9 0.1 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Pentapeptide PF00805.22 KOO21434.1 - 0.08 12.6 0.4 3.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Pentapeptide repeats (8 copies) Exonuc_VII_L PF02601.15 KOO21435.1 - 0.02 14.4 2.5 0.029 13.9 2.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit BLOC1_2 PF10046.9 KOO21435.1 - 0.024 15.0 3.9 2 8.8 2.0 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 KOO21435.1 - 0.095 12.7 1.4 0.65 10.0 0.4 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 KOO21435.1 - 0.33 10.3 10.1 0.49 9.7 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cep57_CLD PF14073.6 KOO21435.1 - 0.33 11.0 13.6 0.68 9.9 13.7 1.5 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 TMPIT PF07851.13 KOO21435.1 - 3.2 6.9 6.6 0.9 8.7 1.9 1.9 1 1 0 2 2 2 0 TMPIT-like protein MutS_III PF05192.18 KOO21435.1 - 3.4 7.8 6.3 5.5 7.2 6.3 1.3 1 0 0 1 1 1 0 MutS domain III CorA PF01544.18 KOO21435.1 - 3.7 6.8 4.8 5.3 6.3 4.8 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein SlyX PF04102.12 KOO21435.1 - 5.5 7.7 19.4 4.7 7.9 1.7 4.0 1 1 2 3 3 3 0 SlyX Atg14 PF10186.9 KOO21435.1 - 7.2 5.6 13.6 0.74 8.8 7.9 1.8 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 RRP36 PF06102.12 KOO21435.1 - 7.7 6.4 11.1 26 4.7 10.6 1.7 1 1 0 1 1 1 0 rRNA biogenesis protein RRP36 DSPc PF00782.20 KOO21436.1 - 9e-29 100.0 0.0 1.3e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOO21436.1 - 0.00087 18.9 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_8 PF13855.6 KOO21437.1 - 5.6e-06 26.0 2.7 0.004 16.9 0.1 3.0 2 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KOO21437.1 - 0.00084 19.7 5.0 0.4 11.2 0.1 4.2 2 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO21437.1 - 0.016 14.7 0.1 0.039 13.5 0.1 1.6 1 1 0 1 1 1 0 Leucine-rich repeat Peptidase_C65 PF10275.9 KOO21438.1 - 1.1e-13 51.3 0.0 1.6e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain WSC PF01822.19 KOO21438.1 - 3e-11 43.4 3.5 6e-11 42.4 3.5 1.5 1 0 0 1 1 1 1 WSC domain fn3 PF00041.21 KOO21438.1 - 3.3e-07 30.5 0.0 1.4e-05 25.3 0.0 3.2 2 1 0 2 2 2 1 Fibronectin type III domain Ribosomal_L18 PF17135.4 KOO21439.1 - 1.6e-78 262.4 0.3 1.8e-78 262.3 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 KOO21439.1 - 0.014 16.1 0.0 0.025 15.3 0.0 1.5 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A PI3_PI4_kinase PF00454.27 KOO21440.1 - 5.8e-10 39.4 0.0 6.3e-05 22.9 0.1 2.2 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PH PF00169.29 KOO21441.1 - 0.0005 20.5 0.0 0.0008 19.9 0.0 1.4 1 0 0 1 1 1 1 PH domain AAA_12 PF13087.6 KOO21442.1 - 2.7e-46 157.7 0.0 4e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO21442.1 - 2.6e-28 99.5 0.0 8.4e-14 52.0 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 KOO21442.1 - 7e-15 55.3 0.0 1.9e-14 53.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO21442.1 - 5.4e-10 39.8 0.0 2.8e-09 37.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 KOO21442.1 - 5.5e-07 29.7 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 KOO21442.1 - 2.7e-05 23.7 0.0 0.039 13.4 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein UvrD_C PF13361.6 KOO21442.1 - 0.0001 21.8 0.0 0.00046 19.7 0.0 2.0 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 KOO21442.1 - 0.00064 20.0 0.1 0.0023 18.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain DUF3410 PF11890.8 KOO21442.1 - 0.0014 18.4 0.2 0.0044 16.8 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3410) UvrD-helicase PF00580.21 KOO21442.1 - 0.0042 16.7 0.0 0.015 14.9 0.0 1.8 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain T2SSE PF00437.20 KOO21442.1 - 0.036 13.1 0.0 0.061 12.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Helicase_RecD PF05127.14 KOO21442.1 - 0.04 13.8 0.0 0.13 12.1 0.0 1.9 1 1 0 1 1 1 0 Helicase FtsK_SpoIIIE PF01580.18 KOO21442.1 - 0.056 12.8 0.0 4.4 6.6 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA PF00004.29 KOO21442.1 - 0.057 13.8 1.1 0.19 12.1 1.0 1.9 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 KOO21442.1 - 0.063 12.8 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 KOO21442.1 - 0.074 12.8 0.1 17 5.0 0.1 3.2 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase PIF1 PF05970.14 KOO21442.1 - 0.1 11.8 0.0 7.2 5.7 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_28 PF13521.6 KOO21442.1 - 0.1 12.8 0.3 2.3 8.4 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 KOO21442.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 KOO21442.1 - 0.17 11.5 0.0 0.43 10.2 0.0 1.7 2 0 0 2 2 1 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 KOO21442.1 - 0.2 11.2 0.0 0.34 10.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region CBFD_NFYB_HMF PF00808.23 KOO21443.1 - 2.3e-09 37.4 0.0 4.2e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-CXXC PF02008.20 KOO21443.1 - 1.3e-07 31.5 21.1 3.2e-07 30.3 21.1 1.7 1 1 0 1 1 1 1 CXXC zinc finger domain Myosin_head PF00063.21 KOO21444.1 - 5e-195 649.6 0.0 6.5e-195 649.2 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 KOO21444.1 - 0.001 19.5 0.0 0.0097 16.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 KOO21444.1 - 0.023 14.0 0.0 0.063 12.5 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin GAD PF02938.14 KOO21444.1 - 0.23 11.7 4.6 1.3 9.3 0.3 3.1 3 0 0 3 3 3 0 GAD domain EF-hand_1 PF00036.32 KOO21445.1 - 4.5e-11 41.5 1.6 0.00017 20.9 0.8 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO21445.1 - 2.8e-08 33.0 2.1 0.00087 19.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO21445.1 - 2e-07 31.3 0.4 3.2e-07 30.7 0.4 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO21445.1 - 9.5e-06 24.9 0.6 0.1 12.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21445.1 - 2.6e-05 24.0 0.6 6.8e-05 22.6 0.2 1.8 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_4 PF12763.7 KOO21445.1 - 0.00051 20.0 0.4 0.0011 18.9 0.4 1.6 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand FAM183 PF14886.6 KOO21446.1 - 0.0064 17.2 0.0 0.011 16.5 0.0 1.3 1 0 0 1 1 1 1 FAM183A and FAM183B related EF-hand_6 PF13405.6 KOO21446.1 - 0.017 15.0 0.1 11 6.2 0.0 2.7 2 1 0 2 2 2 0 EF-hand domain Peptidase_M16_M PF16187.5 KOO21449.1 - 3.6e-78 262.7 0.0 4.1e-45 154.2 0.0 2.2 2 0 0 2 2 2 2 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 KOO21449.1 - 5e-40 136.9 0.0 1.4e-39 135.4 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOO21449.1 - 1.4e-33 116.5 0.0 3.7e-19 69.5 0.0 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain PDZ_6 PF17820.1 KOO21449.1 - 0.12 12.3 0.1 0.35 10.7 0.1 1.8 1 0 0 1 1 1 0 PDZ domain PRIMA1 PF16101.5 KOO21449.1 - 0.2 11.7 2.2 0.41 10.7 2.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 UPF0029 PF01205.19 KOO21450.1 - 3.4e-18 65.9 0.1 6.2e-18 65.1 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 SVIP PF15811.5 KOO21450.1 - 3 8.4 11.0 6.5 7.3 11.0 1.5 1 0 0 1 1 1 0 Small VCP/p97-interacting protein Thioredoxin PF00085.20 KOO21451.1 - 0.0025 17.8 0.0 0.065 13.2 0.0 2.8 2 1 1 3 3 3 1 Thioredoxin cNMP_binding PF00027.29 KOO21452.1 - 3.3e-17 62.3 0.0 5e-08 32.9 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain SET PF00856.28 KOO21453.1 - 0.0051 17.2 0.0 0.017 15.5 0.0 1.9 1 1 0 1 1 1 1 SET domain RNase_T PF00929.24 KOO21454.1 - 1.5e-24 87.4 0.0 1.8e-24 87.1 0.0 1.1 1 0 0 1 1 1 1 Exonuclease Ras PF00071.22 KOO21455.1 - 1.3e-36 125.7 0.0 1.6e-36 125.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO21455.1 - 1.1e-19 70.9 0.0 1.5e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO21455.1 - 5.2e-12 45.6 0.0 6e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MoeA_N PF03453.17 KOO21455.1 - 0.0048 16.7 0.0 0.0075 16.1 0.0 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) TniB PF05621.11 KOO21455.1 - 0.022 14.2 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 KOO21455.1 - 0.15 12.4 0.0 0.17 12.2 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain CAP59_mtransfer PF11735.8 KOO21455.1 - 0.16 11.6 0.0 0.21 11.2 0.0 1.2 1 1 0 1 1 1 0 Cryptococcal mannosyltransferase 1 PduV-EutP PF10662.9 KOO21455.1 - 0.17 11.6 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Ax_dynein_light PF10211.9 KOO21456.1 - 4.2e-07 30.1 6.1 1.2e-06 28.6 6.1 1.7 1 1 0 1 1 1 1 Axonemal dynein light chain EF-hand_6 PF13405.6 KOO21456.1 - 0.0002 21.0 0.3 0.0071 16.2 0.1 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO21456.1 - 0.0003 20.1 0.3 0.0011 18.4 0.3 2.0 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO21456.1 - 0.0027 17.5 0.1 0.0078 16.0 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 KOO21456.1 - 0.012 16.0 0.1 0.039 14.4 0.1 1.9 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 KOO21456.1 - 0.059 12.9 0.9 0.14 11.7 0.9 1.6 1 0 0 1 1 1 0 EF hand HD_4 PF13328.6 KOO21456.1 - 1.3 8.7 10.7 0.034 13.9 3.4 2.1 2 0 0 2 2 2 0 HD domain Sybindin PF04099.12 KOO21457.1 - 8.7e-27 93.8 0.1 9.3e-27 93.7 0.1 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 KOO21457.1 - 8.3e-10 38.9 0.0 9.7e-10 38.7 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region YTH PF04146.15 KOO21458.1 - 1.9e-47 161.3 0.0 3.1e-47 160.6 0.0 1.4 1 0 0 1 1 1 1 YT521-B-like domain MFS_1 PF07690.16 KOO21459.1 - 9.5e-16 57.6 21.2 9.5e-16 57.6 21.2 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF5379 PF17350.2 KOO21459.1 - 0.02 15.2 1.0 0.096 13.0 1.0 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5379) Abhydrolase_6 PF12697.7 KOO21459.1 - 1.2 9.6 8.4 0.76 10.3 1.8 2.3 1 1 1 2 2 2 0 Alpha/beta hydrolase family LRR_5 PF13306.6 KOO21463.1 - 1.7e-07 31.3 0.0 2e-07 31.0 0.0 1.0 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) zf-RING_2 PF13639.6 KOO21464.1 - 9.4e-14 51.5 9.4 1.2e-13 51.1 9.4 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOO21464.1 - 3.4e-09 36.3 7.0 5.6e-09 35.6 7.0 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KOO21464.1 - 2.6e-08 33.6 10.8 3.6e-08 33.1 10.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO21464.1 - 4.8e-08 32.7 9.4 6.4e-08 32.3 9.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOO21464.1 - 1e-07 32.1 10.2 1.9e-07 31.2 10.2 1.4 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KOO21464.1 - 3.1e-07 30.3 8.2 4e-07 29.9 8.2 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOO21464.1 - 1.6e-06 27.9 6.3 2.4e-06 27.3 6.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO21464.1 - 9.2e-06 25.6 6.9 1.4e-05 25.0 6.9 1.3 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KOO21464.1 - 0.00011 21.9 7.0 0.00017 21.4 7.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KOO21464.1 - 0.011 15.8 7.0 0.021 14.9 7.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 KOO21464.1 - 0.018 15.1 6.3 0.042 14.0 6.3 1.6 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 KOO21464.1 - 0.024 14.8 9.1 0.18 12.0 9.1 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain YdjO PF14169.6 KOO21464.1 - 0.059 13.1 2.0 0.73 9.6 0.1 2.2 2 0 0 2 2 2 0 Cold-inducible protein YdjO Zn_ribbon_17 PF17120.5 KOO21464.1 - 0.13 11.9 6.7 0.2 11.3 6.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_10 PF16685.5 KOO21464.1 - 0.42 10.8 6.4 0.64 10.2 6.4 1.3 1 0 0 1 1 1 0 zinc RING finger of MSL2 Ribosomal_S13 PF00416.22 KOO21465.1 - 6.9e-17 62.0 0.1 8.5e-16 58.5 0.1 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 PPPI_inhib PF14895.6 KOO21467.1 - 1.4e-13 50.8 2.1 5.2e-10 39.0 0.5 2.1 2 0 0 2 2 2 2 Protein phosphatase 1 inhibitor aGPT-Pplase2 PF18724.1 KOO21467.1 - 0.17 11.6 1.1 0.29 10.9 1.1 1.3 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 2 Pkinase PF00069.25 KOO21468.1 - 3.9e-64 216.6 0.0 5e-64 216.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21468.1 - 2e-27 96.1 0.0 2.6e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KOO21468.1 - 8.2e-15 55.2 0.0 1.6e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.24 KOO21468.1 - 7.6e-07 29.7 0.9 1.6e-06 28.7 0.9 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain PH_11 PF15413.6 KOO21468.1 - 4.3e-06 27.1 0.0 1.2e-05 25.6 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain Kinase-like PF14531.6 KOO21468.1 - 1.2e-05 24.8 0.5 0.00042 19.7 0.1 2.4 2 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 KOO21468.1 - 0.00055 19.6 0.0 0.55 9.8 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 PH_9 PF15410.6 KOO21468.1 - 0.0009 19.6 0.0 0.0028 18.0 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_17 PF18012.1 KOO21468.1 - 0.033 13.9 0.1 0.087 12.6 0.0 1.7 2 0 0 2 2 2 0 PH domain F_bP_aldolase PF01116.20 KOO21470.1 - 4.1e-89 298.8 0.0 4.8e-89 298.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II DUF4326 PF14216.6 KOO21471.1 - 3.8e-06 27.5 1.0 2e-05 25.2 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4326) RVT_1 PF00078.27 KOO21471.1 - 0.00018 21.1 0.0 0.00036 20.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 KOO21473.1 - 0.0061 16.1 0.0 0.012 15.2 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family COesterase PF00135.28 KOO21474.1 - 7.4e-53 180.2 0.0 1.2e-52 179.5 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KOO21474.1 - 2.2e-08 34.3 5.8 0.00035 20.5 0.3 3.8 3 1 0 3 3 3 2 alpha/beta hydrolase fold Rod_cone_degen PF15201.6 KOO21474.1 - 0.1 12.7 0.4 0.32 11.1 0.4 1.8 1 0 0 1 1 1 0 Progressive rod-cone degeneration adh_short_C2 PF13561.6 KOO21475.1 - 3.2e-64 216.7 0.7 3.8e-64 216.5 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO21475.1 - 1e-50 171.9 3.0 1.3e-50 171.6 3.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOO21475.1 - 4e-13 49.7 2.4 5.9e-13 49.1 2.4 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOO21475.1 - 1.5e-05 24.6 0.5 3.8e-05 23.3 0.5 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO21475.1 - 8.2e-05 21.7 1.3 9.8e-05 21.5 1.3 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KOO21475.1 - 0.00025 20.2 0.3 0.00038 19.6 0.3 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Methyltransf_25 PF13649.6 KOO21475.1 - 0.0065 17.1 0.2 0.012 16.3 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain Pyr_redox PF00070.27 KOO21475.1 - 0.0091 16.5 0.2 0.022 15.3 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOO21475.1 - 0.01 15.1 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GDP_Man_Dehyd PF16363.5 KOO21475.1 - 0.025 14.0 0.1 0.038 13.4 0.1 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 3HCDH_N PF02737.18 KOO21475.1 - 0.037 13.9 0.2 0.059 13.2 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 KOO21475.1 - 0.04 13.3 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TauD PF02668.16 KOO21476.1 - 1.5e-12 47.9 0.2 2e-09 37.6 0.0 2.8 2 1 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family Rrn6 PF10214.9 KOO21476.1 - 5.3 5.4 5.4 7.6 4.9 5.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor PAS PF00989.25 KOO21477.1 - 0.0073 16.3 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 PAS fold Myosin_head PF00063.21 KOO21478.1 - 6.5e-188 626.1 0.0 8.2e-188 625.8 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 KOO21478.1 - 0.0021 18.3 0.1 0.073 13.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 KOO21478.1 - 0.04 14.3 0.0 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO21478.1 - 0.044 14.2 0.0 0.17 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Myosin_N PF02736.19 KOO21478.1 - 0.06 13.2 0.9 0.17 11.8 0.9 1.7 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain RsgA_GTPase PF03193.16 KOO21478.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 KOO21478.1 - 0.16 12.0 0.0 0.59 10.1 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Vta1 PF04652.16 KOO21479.1 - 3.5e-29 101.6 0.4 5e-29 101.2 0.4 1.2 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 KOO21479.1 - 8.7e-08 31.7 0.4 1.8e-07 30.8 0.4 1.5 1 0 0 1 1 1 1 Vta1 C-terminal domain MIT PF04212.18 KOO21479.1 - 0.057 13.5 0.4 0.81 9.8 0.0 2.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain IHABP4_N PF16174.5 KOO21481.1 - 5.5 7.6 6.4 7.8 7.1 6.4 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal LRR_6 PF13516.6 KOO21482.1 - 3e-23 79.9 28.1 0.0055 16.7 0.0 9.9 11 0 0 11 11 11 7 Leucine Rich repeat LRR_4 PF12799.7 KOO21482.1 - 7.1e-06 26.3 4.3 2.6 8.6 0.0 5.7 3 2 3 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO21482.1 - 0.047 13.4 9.2 18 5.2 0.6 5.7 2 2 3 5 5 5 0 Leucine rich repeat Roc PF08477.13 KOO21482.1 - 0.059 13.6 0.0 8.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 KOO21482.1 - 0.21 11.8 1.3 59 3.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain RelB_leu_zip PF16180.5 KOO21482.1 - 0.31 11.1 1.7 14 5.7 0.1 3.4 1 1 1 2 2 2 0 RelB leucine zipper ATP_bind_1 PF03029.17 KOO21482.1 - 0.36 10.6 0.5 0.65 9.7 0.5 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DHHC PF01529.20 KOO21483.1 - 1.1e-34 119.5 13.5 1.1e-34 119.5 13.5 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase LRR_6 PF13516.6 KOO21484.1 - 8.9e-31 103.3 20.7 0.0002 21.1 0.1 9.7 10 0 0 10 10 10 7 Leucine Rich repeat LRR_4 PF12799.7 KOO21484.1 - 4.6e-06 26.9 0.0 0.66 10.5 0.0 4.1 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO21484.1 - 0.0017 18.1 7.0 1.7 8.4 0.3 4.8 4 2 0 4 4 4 2 Leucine rich repeat Fib_alpha PF08702.10 KOO21484.1 - 0.029 14.5 5.6 0.97 9.6 0.8 3.2 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Snapin_Pallidin PF14712.6 KOO21484.1 - 0.15 12.5 5.2 2 8.9 2.6 3.8 1 1 1 2 2 2 0 Snapin/Pallidin DUF4795 PF16043.5 KOO21484.1 - 0.24 11.0 12.9 1.1 8.9 12.9 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) KxDL PF10241.9 KOO21484.1 - 1 9.7 12.0 0.77 10.1 1.0 4.3 3 2 2 5 5 5 0 Uncharacterized conserved protein DUF4618 PF15397.6 KOO21484.1 - 1.4 8.2 10.8 0.33 10.3 5.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Atg14 PF10186.9 KOO21484.1 - 7 5.6 18.7 11 5.0 11.5 2.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 RIH_assoc PF08454.11 KOO21485.1 - 3.4e-21 75.0 1.4 2.6e-20 72.2 1.4 2.7 1 0 0 1 1 1 1 RyR and IP3R Homology associated Ins145_P3_rec PF08709.11 KOO21485.1 - 1.8e-18 66.6 0.0 1.1e-16 60.7 0.0 2.4 1 1 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor Ion_trans PF00520.31 KOO21485.1 - 3.4e-10 39.6 7.7 7.5e-10 38.4 7.7 1.5 1 0 0 1 1 1 1 Ion transport protein MIR PF02815.19 KOO21485.1 - 0.11 12.3 0.0 9.3 6.1 0.0 2.5 2 0 0 2 2 2 0 MIR domain CN_hydrolase PF00795.22 KOO21486.1 - 2.4e-43 148.3 0.0 3.1e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ATP-grasp_4 PF13535.6 KOO21487.1 - 0.00016 21.3 0.0 0.00027 20.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 KOO21487.1 - 0.0018 18.0 0.0 0.021 14.6 0.0 2.4 2 1 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 KOO21487.1 - 0.0033 17.5 0.0 0.0067 16.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Glyc_hyd_38C_2 PF18230.1 KOO21488.1 - 0.05 13.7 0.1 5.5 7.2 0.0 2.3 2 1 0 2 2 2 0 Glycosyl hydrolases family 38 C-terminal sub-domain ANAPC10 PF03256.16 KOO21489.1 - 1.4e-47 161.7 0.2 1.8e-47 161.4 0.2 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) PITH PF06201.13 KOO21489.1 - 0.0019 18.5 0.1 0.0032 17.7 0.1 1.3 1 1 0 1 1 1 1 PITH domain PALP PF00291.25 KOO21490.1 - 3.8e-65 220.2 4.6 6.4e-65 219.5 4.6 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 KOO21490.1 - 1.5e-28 98.4 0.0 8.2e-17 60.8 0.0 2.5 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Thioredoxin_8 PF13905.6 KOO21492.1 - 1.4e-09 38.1 0.0 1.6e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Mg_trans_NIPA PF05653.14 KOO21493.1 - 9.7e-17 61.0 9.9 4.4e-09 35.9 1.1 2.2 2 0 0 2 2 2 2 Magnesium transporter NIPA Multi_Drug_Res PF00893.19 KOO21493.1 - 0.052 14.2 14.6 0.055 14.1 1.2 3.0 2 1 0 2 2 2 0 Small Multidrug Resistance protein EamA PF00892.20 KOO21493.1 - 0.17 12.0 31.2 0.98 9.6 1.1 3.9 3 2 1 4 4 4 0 EamA-like transporter family Ion_trans PF00520.31 KOO21494.1 - 2e-18 66.5 7.2 3.8e-18 65.6 7.2 1.5 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 KOO21494.1 - 0.16 12.0 0.0 0.33 11.0 0.0 1.6 1 1 0 1 1 1 0 Cyclic nucleotide-binding domain Spc24 PF08286.11 KOO21495.1 - 4e-08 33.4 1.0 4e-08 33.4 1.0 2.0 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 INCA1 PF15142.6 KOO21495.1 - 0.015 15.3 0.1 0.018 15.1 0.1 1.2 1 0 0 1 1 1 0 INCA1 HsbA PF12296.8 KOO21495.1 - 0.055 13.9 3.4 0.043 14.2 1.1 1.9 1 1 1 2 2 2 0 Hydrophobic surface binding protein A Syntaxin-6_N PF09177.11 KOO21495.1 - 0.056 14.0 7.3 0.14 12.7 6.1 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Leu_zip PF15294.6 KOO21495.1 - 0.061 12.8 10.4 0.6 9.6 1.4 2.1 1 1 1 2 2 2 0 Leucine zipper DUF359 PF04019.12 KOO21495.1 - 0.15 11.7 0.8 0.29 10.8 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF359) Mcm10 PF09332.11 KOO21495.1 - 0.31 10.4 5.9 0.39 10.1 5.9 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Gp-FAR-1 PF05823.12 KOO21495.1 - 0.37 11.2 4.3 0.71 10.2 3.4 1.8 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) YabA PF06156.13 KOO21495.1 - 0.97 10.1 7.0 0.45 11.2 3.3 2.0 2 0 0 2 2 2 0 Initiation control protein YabA UPF0242 PF06785.11 KOO21495.1 - 1.4 9.0 11.1 4 7.5 11.1 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ZapB PF06005.12 KOO21495.1 - 1.6 9.2 10.0 2 8.9 7.1 2.4 1 1 1 2 2 2 0 Cell division protein ZapB ADIP PF11559.8 KOO21495.1 - 2.2 8.3 15.0 11 6.0 15.0 2.1 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 KOO21495.1 - 2.8 6.7 12.6 4.9 5.9 12.6 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 KOO21495.1 - 3.6 8.1 10.8 16 6.1 10.9 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 KOO21495.1 - 4 7.7 12.2 8.8 6.5 11.2 1.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 BST2 PF16716.5 KOO21495.1 - 5.4 7.7 10.7 9.5 6.9 0.2 2.2 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Glyco_transf_8 PF01501.20 KOO21496.1 - 1.8e-09 37.5 0.2 3.5e-08 33.3 0.2 2.6 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mito_carr PF00153.27 KOO21497.1 - 1.8e-35 120.7 0.7 8.4e-20 70.5 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF1336 PF07059.12 KOO21499.1 - 6.1e-53 180.2 0.0 7.6e-53 179.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) SKG6 PF08693.10 KOO21499.1 - 0.0059 16.0 5.3 0.011 15.1 5.3 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM51 PF15345.6 KOO21499.1 - 0.2 11.4 0.1 0.55 10.0 0.1 1.7 1 1 0 1 1 1 0 Transmembrane protein 51 PP2C PF00481.21 KOO21500.1 - 3.5e-37 128.5 0.0 4.6e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO21500.1 - 9.4e-05 22.1 0.7 0.00027 20.6 0.0 2.1 2 1 0 2 2 2 1 Protein phosphatase 2C PEMT PF04191.13 KOO21501.1 - 1.5e-05 25.4 0.2 1.5e-05 25.4 0.2 3.5 3 1 0 3 3 3 1 Phospholipid methyltransferase DUF962 PF06127.11 KOO21501.1 - 9.3 6.4 12.3 1.1 9.4 4.6 3.2 2 2 0 2 2 2 0 Protein of unknown function (DUF962) GTP_EFTU PF00009.27 KOO21503.1 - 5.9e-52 176.1 0.0 8.2e-52 175.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KOO21503.1 - 7.6e-19 67.5 0.0 1.7e-18 66.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 KOO21503.1 - 0.0072 16.4 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II Mito_carr PF00153.27 KOO21504.1 - 2.5e-11 43.3 2.0 1e-10 41.4 0.0 2.7 3 0 0 3 3 3 1 Mitochondrial carrier protein Helicase_C PF00271.31 KOO21504.1 - 3.1e-08 33.9 0.0 5.9e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2116 PF09889.9 KOO21504.1 - 0.069 13.1 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF900 PF05990.12 KOO21506.1 - 2.2e-16 60.1 0.0 3e-12 46.6 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF900) CKS PF01111.19 KOO21506.1 - 0.067 13.5 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase regulatory subunit HALZ PF02183.18 KOO21507.1 - 0.0074 16.5 0.8 1.8 8.9 0.0 2.5 2 0 0 2 2 2 2 Homeobox associated leucine zipper DivIC PF04977.15 KOO21507.1 - 0.0088 15.8 2.8 7.5 6.4 0.0 3.4 3 1 0 3 3 3 2 Septum formation initiator DNA_methylase PF00145.17 KOO21508.1 - 3.4e-53 181.1 0.0 4.3e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Met_10 PF02475.16 KOO21508.1 - 0.055 13.2 0.0 0.093 12.5 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein PsbP PF01789.16 KOO21509.1 - 1.4e-08 35.0 0.2 0.00011 22.4 0.0 2.1 1 1 0 2 2 2 2 PsbP tRNA_bind PF01588.20 KOO21510.1 - 1.4e-27 95.7 0.0 2.2e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain Myosin_head PF00063.21 KOO21511.1 - 7.3e-174 579.7 8.7 4.2e-132 441.7 0.0 2.9 2 1 1 3 3 3 2 Myosin head (motor domain) Tub PF01167.18 KOO21511.1 - 8.6e-45 153.4 0.0 8.6e-45 153.4 0.0 1.8 2 0 0 2 2 2 1 Tub family DUF3527 PF12043.8 KOO21511.1 - 0.00025 20.7 0.0 0.00025 20.7 0.0 2.4 2 0 0 2 2 1 1 Domain of unknown function (DUF3527) WW PF00397.26 KOO21511.1 - 0.00085 19.4 0.1 0.0016 18.5 0.1 1.5 1 0 0 1 1 1 1 WW domain AAA_22 PF13401.6 KOO21511.1 - 0.025 14.8 0.0 0.11 12.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain Caldesmon PF02029.15 KOO21511.1 - 0.11 11.3 31.2 0.18 10.6 31.2 1.2 1 0 0 1 1 1 0 Caldesmon IQ PF00612.27 KOO21511.1 - 0.21 11.4 1.0 0.64 10.0 1.0 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Tugs PF17840.1 KOO21511.1 - 0.47 10.7 4.7 0.75 10.0 0.6 3.0 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain AAA_16 PF13191.6 KOO21511.1 - 0.48 10.8 0.0 0.48 10.8 0.0 3.3 2 1 0 2 2 1 0 AAA ATPase domain TFIIA PF03153.13 KOO21511.1 - 1.1 9.2 14.2 1.8 8.4 14.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 KOO21511.1 - 3 6.0 19.7 5 5.3 19.7 1.2 1 0 0 1 1 1 0 CDC45-like protein EF-hand_7 PF13499.6 KOO21512.1 - 7.5e-24 84.0 3.3 3.3e-14 53.1 0.4 3.7 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21512.1 - 2.7e-21 73.6 6.3 1.1e-06 28.1 0.0 5.1 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 KOO21512.1 - 1.1e-20 71.6 7.1 6.9e-06 25.3 0.0 5.4 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 KOO21512.1 - 4.3e-15 54.4 8.4 1.9e-05 23.9 0.1 4.9 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO21512.1 - 9.6e-15 54.2 7.5 2.1e-08 33.9 0.9 4.1 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 KOO21512.1 - 1.5e-06 28.4 0.1 0.00037 20.8 0.1 3.3 3 0 0 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO21512.1 - 0.00018 21.8 2.4 0.079 13.3 1.2 3.2 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO21512.1 - 0.0053 17.6 0.3 0.58 11.1 0.0 2.8 3 0 0 3 3 2 1 EF-hand domain APG6_N PF17675.1 KOO21512.1 - 0.0058 17.1 15.1 0.0058 17.1 15.1 2.4 3 0 0 3 3 2 1 Apg6 coiled-coil region JIP_LZII PF16471.5 KOO21512.1 - 0.022 15.0 1.8 0.022 15.0 1.8 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II RusA PF05866.11 KOO21512.1 - 0.025 15.1 2.7 0.083 13.4 2.6 2.1 1 1 0 1 1 1 0 Endodeoxyribonuclease RusA Fmp27_WPPW PF10359.9 KOO21512.1 - 0.16 10.8 7.7 0.29 9.9 7.7 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain EF-hand_4 PF12763.7 KOO21512.1 - 0.6 10.1 8.4 4.1 7.4 0.9 3.9 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand ALMT PF11744.8 KOO21512.1 - 1.6 7.5 9.5 3.8 6.3 9.5 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Occludin_ELL PF07303.13 KOO21512.1 - 2.1 9.1 9.2 1.8 9.4 2.5 3.1 2 1 1 3 3 3 0 Occludin homology domain XRN_M PF17846.1 KOO21512.1 - 4 6.3 8.4 8.5 5.2 8.4 1.5 1 0 0 1 1 1 0 Xrn1 helical domain U-box PF04564.15 KOO21514.1 - 2.3e-11 43.7 0.0 3.9e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO21514.1 - 5.9e-09 36.3 9.5 3.6e-05 24.3 1.0 3.6 3 0 0 3 3 3 2 Sel1 repeat zf-Nse PF11789.8 KOO21514.1 - 0.00095 18.9 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO21514.1 - 0.019 15.1 0.0 0.042 14.0 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Methyltransf_16 PF10294.9 KOO21515.1 - 0.00011 22.0 0.0 0.00015 21.6 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase ATP-synt_ab PF00006.25 KOO21518.1 - 3.3e-62 209.9 0.0 4.5e-62 209.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KOO21518.1 - 9.1e-12 45.3 0.6 1.9e-11 44.3 0.6 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain PSK_trans_fac PF07704.11 KOO21519.1 - 0.048 14.4 0.3 0.063 14.0 0.3 1.2 1 0 0 1 1 1 0 Rv0623-like transcription factor Ank_2 PF12796.7 KOO21520.1 - 2.1e-15 57.0 0.0 2.6e-09 37.5 0.0 3.7 1 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ion_trans PF00520.31 KOO21520.1 - 1.8e-13 50.3 0.0 2.8e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Ion transport protein Ank_4 PF13637.6 KOO21520.1 - 1.8e-12 47.5 0.1 0.0028 18.2 0.0 5.0 3 1 3 6 6 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO21520.1 - 8.9e-11 41.8 2.9 0.0049 17.2 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO21520.1 - 6.6e-10 38.4 0.0 0.22 12.2 0.0 5.8 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 KOO21520.1 - 3.8e-08 33.4 0.0 0.16 12.5 0.0 5.8 6 0 0 6 6 5 1 Ankyrin repeat Apolipoprotein PF01442.18 KOO21520.1 - 0.013 15.4 9.1 0.03 14.2 9.1 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF885 PF05960.11 KOO21520.1 - 0.036 13.7 0.3 0.056 13.1 0.3 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) DUF3584 PF12128.8 KOO21520.1 - 0.29 8.6 5.5 0.4 8.1 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) BshC PF10079.9 KOO21520.1 - 0.34 9.6 1.8 0.5 9.0 1.8 1.1 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC Baculo_PEP_C PF04513.12 KOO21520.1 - 0.42 10.7 3.3 0.43 10.6 1.9 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Exonuc_VII_L PF02601.15 KOO21520.1 - 0.52 9.8 2.6 0.87 9.1 2.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 KOO21520.1 - 0.56 10.6 10.4 1.4 9.3 10.4 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Tmemb_cc2 PF10267.9 KOO21520.1 - 1 8.4 7.1 1.5 7.8 7.1 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Phage_Mu_Gam PF07352.12 KOO21520.1 - 1.2 9.0 4.2 2.8 7.8 4.2 1.6 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein CAP_GLY PF01302.25 KOO21521.1 - 4.8e-18 64.9 3.2 9.1e-18 64.0 1.8 1.9 2 0 0 2 2 2 1 CAP-Gly domain Arm PF00514.23 KOO21522.1 - 8.9e-08 31.9 0.1 0.0027 17.7 0.1 2.2 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat FeoA PF04023.14 KOO21523.1 - 1.8e-05 24.9 3.7 14 6.1 0.0 5.9 7 0 0 7 7 7 1 FeoA domain Ribosomal_L7Ae PF01248.26 KOO21523.1 - 2.2e-05 24.1 1.0 2.9 7.7 0.1 5.2 3 2 3 6 6 6 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF3747 PF12565.8 KOO21523.1 - 0.0061 15.9 0.0 12 5.2 0.0 4.0 2 2 3 5 5 5 1 Protein of unknown function (DUF3747) CENP-H PF05837.12 KOO21523.1 - 0.011 16.2 1.5 11 6.5 0.2 4.4 2 2 4 6 6 6 0 Centromere protein H (CENP-H) Cytadhesin_P30 PF07271.11 KOO21523.1 - 0.081 12.5 2.0 31 4.0 0.1 3.8 2 2 3 5 5 5 0 Cytadhesin P30/P32 ThiC-associated PF13667.6 KOO21523.1 - 0.17 11.7 0.9 72 3.3 0.1 4.0 3 2 2 5 5 5 0 ThiC-associated domain PrgH PF09480.10 KOO21523.1 - 0.2 10.9 1.0 11 5.2 0.1 2.9 2 1 0 3 3 3 0 Type III secretion system protein PrgH-EprH (PrgH) Poty_PP PF08440.10 KOO21523.1 - 1.1 8.2 3.9 36 3.3 0.0 3.1 2 2 2 4 4 4 0 Potyviridae polyprotein Sel1 PF08238.12 KOO21524.1 - 1.1e-30 105.4 37.6 6e-08 33.1 0.9 6.2 7 0 0 7 7 7 5 Sel1 repeat PPR_long PF17177.4 KOO21524.1 - 0.052 12.9 0.8 9.6 5.5 0.1 3.5 1 1 2 3 3 3 0 Pentacotripeptide-repeat region of PRORP Metallophos_C PF14008.6 KOO21525.1 - 2.5e-07 31.4 0.2 7.1e-07 30.0 0.1 1.9 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 KOO21525.1 - 1.2e-06 29.0 0.2 2.7e-06 27.8 0.2 1.6 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 KOO21525.1 - 2.5e-06 28.2 2.2 0.0003 21.3 2.2 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Zeta_toxin PF06414.12 KOO21526.1 - 1.6e-16 60.2 0.0 7.8e-16 58.0 0.0 1.8 1 1 1 2 2 2 1 Zeta toxin AAA_33 PF13671.6 KOO21526.1 - 2.4e-05 24.5 0.0 6.8e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain MFS_1 PF07690.16 KOO21527.1 - 4.4e-21 75.2 28.8 5.8e-15 55.1 19.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO21527.1 - 0.00086 18.3 8.8 0.065 12.1 4.9 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 KOO21527.1 - 0.0043 16.0 3.9 0.093 11.6 0.3 2.6 2 1 1 3 3 3 2 MFS_1 like family Kinesin PF00225.23 KOO21528.1 - 2.5e-37 128.5 0.0 4.2e-37 127.8 0.0 1.4 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO21528.1 - 1.3e-10 41.4 0.0 2.2e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding Bac_DnaA PF00308.18 KOO21528.1 - 0.049 13.5 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein Chon_Sulph_att PF06566.11 KOO21528.1 - 7.2 6.4 6.1 22 4.8 6.1 1.8 1 1 0 1 1 1 0 Chondroitin sulphate attachment domain Kinesin PF00225.23 KOO21529.1 - 1.3e-84 284.0 0.0 1.9e-84 283.5 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO21529.1 - 1.2e-15 57.8 0.0 2e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Homeodomain PF00046.29 KOO21529.1 - 0.00013 21.8 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 Homeodomain Peptidase_S9 PF00326.21 KOO21530.1 - 8.7e-47 159.3 0.0 1.4e-46 158.6 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 KOO21530.1 - 5.8e-10 38.5 0.0 8.7e-07 28.1 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Hydrolase_4 PF12146.8 KOO21530.1 - 0.0025 17.1 0.0 0.0075 15.6 0.0 1.6 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO21530.1 - 0.098 12.3 0.0 0.29 10.8 0.0 1.7 1 1 1 2 2 2 0 alpha/beta hydrolase fold NDUFA12 PF05071.16 KOO21531.1 - 1e-17 64.7 1.8 2.2e-17 63.7 1.7 1.6 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 LRR_6 PF13516.6 KOO21532.1 - 1.2e-22 77.9 13.9 0.00093 19.1 0.1 7.4 7 0 0 7 7 7 6 Leucine Rich repeat FAM25 PF15825.5 KOO21532.1 - 0.02 15.2 8.1 25 5.3 0.1 4.5 4 1 0 4 4 4 0 FAM25 family CbiG_N PF11760.8 KOO21532.1 - 0.91 9.6 12.2 8.6 6.4 0.4 4.2 4 1 1 5 5 5 0 Cobalamin synthesis G N-terminal HGTP_anticodon PF03129.20 KOO21533.1 - 5.5e-12 45.7 0.0 8.3e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KOO21533.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.5 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) DPM3 PF08285.11 KOO21533.1 - 0.12 12.5 0.2 0.25 11.6 0.2 1.5 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Activator-TraM PF11657.8 KOO21534.1 - 3.5 7.4 10.0 0.26 11.1 0.8 2.4 1 1 1 2 2 2 0 Transcriptional activator TraM TIG PF01833.24 KOO21535.1 - 8.4e-56 186.0 30.4 6.9e-06 26.1 0.1 14.6 13 0 0 13 13 13 12 IPT/TIG domain DUF5599 PF18141.1 KOO21535.1 - 0.0099 16.1 0.0 1.6e+02 2.6 0.0 6.0 6 0 0 6 6 6 0 Domain of unknown function (DUF5599) tRNA-synt_2b PF00587.25 KOO21536.1 - 6.4e-14 52.3 0.0 1e-13 51.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DNA_methylase PF00145.17 KOO21538.1 - 4.1e-09 36.3 0.0 5.6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase PHD_2 PF13831.6 KOO21538.1 - 7.7e-07 28.6 5.7 7.7e-07 28.6 5.7 4.5 5 1 0 5 5 5 1 PHD-finger PHD PF00628.29 KOO21538.1 - 4.6e-06 26.4 8.0 4.6e-06 26.4 8.0 4.2 4 0 0 4 4 4 2 PHD-finger zf-HC5HC2H_2 PF13832.6 KOO21538.1 - 0.0002 21.5 4.9 0.0002 21.5 4.9 3.4 3 1 0 3 3 3 1 PHD-zinc-finger like domain Chorein_N PF12624.7 KOO21540.1 - 9.9e-25 86.9 0.0 2.2e-24 85.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 KOO21540.1 - 7.4e-07 29.2 0.0 1.7e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal DER1 PF04511.15 KOO21541.1 - 4.8e-14 52.7 0.1 6.9e-14 52.2 0.1 1.2 1 0 0 1 1 1 1 Der1-like family YusW PF14039.6 KOO21541.1 - 0.089 13.3 0.1 21 5.7 0.0 2.4 2 0 0 2 2 2 0 YusW-like protein RNA_pol_I_A49 PF06870.12 KOO21542.1 - 5.6e-40 137.4 0.0 8.3e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Rubis-subs-bind PF09273.11 KOO21542.1 - 1.9e-10 41.5 0.5 6.7e-10 39.7 0.5 1.9 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Thioredoxin PF00085.20 KOO21544.1 - 1.4e-11 44.3 0.0 2.6e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin DUF1043 PF06295.12 KOO21544.1 - 0.017 15.1 1.3 0.029 14.4 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Myb_CC_LHEQLE PF14379.6 KOO21544.1 - 0.12 12.1 6.1 0.19 11.5 6.1 1.3 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif IATP PF04568.12 KOO21544.1 - 0.47 10.9 3.6 0.93 10.0 3.6 1.6 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP TMA7 PF09072.10 KOO21544.1 - 2.3 9.1 5.4 6 7.8 2.5 2.2 2 0 0 2 2 2 0 Translation machinery associated TMA7 Peptidase_S24 PF00717.23 KOO21545.1 - 1.8e-07 31.0 0.0 1e-06 28.6 0.0 2.2 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.9 KOO21545.1 - 2.9e-05 23.9 0.0 6.6e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 ABC_tran PF00005.27 KOO21547.1 - 5.4e-48 163.0 0.0 1.5e-25 90.3 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO21547.1 - 1.4e-18 67.8 9.2 3e-05 24.0 0.1 4.2 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 KOO21547.1 - 2e-15 56.6 5.3 2e-15 56.6 5.3 4.0 4 1 0 4 4 3 1 ABC transporter RsgA_GTPase PF03193.16 KOO21547.1 - 3.4e-08 33.6 0.1 4.3e-05 23.5 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 KOO21547.1 - 6.8e-08 32.2 0.9 0.0062 16.0 0.0 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KOO21547.1 - 8.1e-07 29.4 1.5 0.01 16.1 0.1 3.1 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOO21547.1 - 6.7e-06 26.6 6.1 0.037 14.4 0.0 3.0 3 0 0 3 3 2 2 AAA ATPase domain AAA_29 PF13555.6 KOO21547.1 - 7.7e-06 25.6 0.4 0.011 15.5 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KOO21547.1 - 2.1e-05 24.6 0.0 0.017 15.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 KOO21547.1 - 7e-05 23.4 3.5 0.78 10.3 0.0 3.9 4 1 0 4 4 3 2 AAA domain AAA_15 PF13175.6 KOO21547.1 - 0.00012 21.9 6.1 0.1 12.3 0.1 3.2 3 1 1 4 4 4 2 AAA ATPase domain AAA_24 PF13479.6 KOO21547.1 - 0.00035 20.4 0.0 0.95 9.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 KOO21547.1 - 0.00068 19.6 0.1 0.74 9.7 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.6 KOO21547.1 - 0.00089 18.9 0.2 2.3 7.8 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 KOO21547.1 - 0.0012 19.1 8.9 0.036 14.3 0.2 3.4 4 0 0 4 4 3 2 AAA domain Roc PF08477.13 KOO21547.1 - 0.0014 18.8 0.1 2.6 8.3 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 KOO21547.1 - 0.0019 18.6 5.4 0.12 12.8 0.0 3.4 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 KOO21547.1 - 0.0034 17.3 0.2 0.56 10.1 0.1 2.6 2 0 0 2 2 2 1 NTPase RNA_helicase PF00910.22 KOO21547.1 - 0.0049 17.2 0.0 0.9 10.0 0.0 2.4 2 0 0 2 2 2 1 RNA helicase SRP54 PF00448.22 KOO21547.1 - 0.005 16.5 2.1 0.31 10.7 0.5 2.8 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_23 PF13476.6 KOO21547.1 - 0.0074 16.8 14.9 0.15 12.5 0.0 3.8 3 1 1 4 4 3 2 AAA domain AAA_5 PF07728.14 KOO21547.1 - 0.014 15.4 0.8 3.5 7.6 0.1 2.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 KOO21547.1 - 0.015 14.5 0.1 1.4 8.1 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 KOO21547.1 - 0.021 14.3 0.2 1.8 8.0 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 KOO21547.1 - 0.027 14.6 6.8 2.5 8.3 0.0 3.6 4 0 0 4 4 3 0 AAA domain SbcCD_C PF13558.6 KOO21547.1 - 0.03 14.5 0.0 0.43 10.8 0.0 2.9 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.6 KOO21547.1 - 0.037 14.1 0.0 7.6 6.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KOO21547.1 - 0.075 13.0 0.5 8.7 6.4 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE dNK PF01712.19 KOO21547.1 - 0.15 11.9 0.0 18 5.1 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase PduV-EutP PF10662.9 KOO21547.1 - 0.15 11.8 0.1 27 4.5 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.15 KOO21547.1 - 0.18 11.7 0.0 2.5 8.0 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain Ras PF00071.22 KOO21547.1 - 0.18 11.4 0.1 21 4.7 0.0 2.4 2 0 0 2 2 2 0 Ras family FeoB_N PF02421.18 KOO21547.1 - 0.22 11.1 0.1 2.1 7.8 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B STI1 PF17830.1 KOO21548.1 - 5.8e-06 26.1 3.5 1.2e-05 25.1 3.5 1.5 1 0 0 1 1 1 1 STI1 domain DUF3094 PF11293.8 KOO21548.1 - 0.11 12.3 0.3 0.32 10.7 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) DUF2208 PF09973.9 KOO21548.1 - 0.17 11.4 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) PNTB_4TM PF12769.7 KOO21548.1 - 0.32 11.5 2.1 0.6 10.6 2.1 1.5 1 0 0 1 1 1 0 4TM region of pyridine nucleotide transhydrogenase, mitoch 7tm_7 PF08395.12 KOO21548.1 - 0.53 9.4 3.4 0.78 8.9 3.4 1.2 1 0 0 1 1 1 0 7tm Chemosensory receptor SAP PF02037.27 KOO21548.1 - 1.5 8.6 4.4 12 5.8 0.1 3.5 4 0 0 4 4 4 0 SAP domain Tetraspanin PF00335.20 KOO21548.1 - 1.8 8.2 8.8 16 5.1 8.8 2.0 1 1 0 1 1 1 0 Tetraspanin family MatE PF01554.18 KOO21549.1 - 1.5e-18 66.9 30.7 5.8e-18 65.1 10.5 3.9 4 0 0 4 4 4 3 MatE Polysacc_synt_C PF14667.6 KOO21549.1 - 7.5e-06 26.1 7.4 7.5e-06 26.1 7.4 4.2 3 3 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain HBS1_N PF08938.10 KOO21550.1 - 7.3 7.0 10.0 0.31 11.4 0.3 3.6 3 1 0 4 4 4 0 HBS1 N-terminus AAA_2 PF07724.14 KOO21551.1 - 2.5e-48 164.4 0.0 1.4e-46 158.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 KOO21551.1 - 1.8e-32 111.3 1.1 1.8e-32 111.3 1.1 2.3 1 1 1 2 2 2 1 AAA lid domain AAA PF00004.29 KOO21551.1 - 2.8e-23 82.8 0.0 2.5e-12 47.3 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO21551.1 - 1.2e-15 57.7 0.1 4.4e-10 39.7 0.0 3.5 4 0 0 4 4 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO21551.1 - 3.5e-13 50.3 9.1 4.3e-06 27.2 0.1 5.1 4 1 1 5 5 5 2 AAA ATPase domain TniB PF05621.11 KOO21551.1 - 9e-10 38.3 0.0 3e-05 23.5 0.0 3.6 2 1 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 KOO21551.1 - 5.5e-09 36.4 5.3 0.0015 18.8 0.2 4.9 3 3 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 KOO21551.1 - 1.2e-07 31.5 0.1 0.00024 20.9 0.0 2.8 3 0 0 3 3 2 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 KOO21551.1 - 6.5e-07 29.2 0.0 0.042 13.6 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 KOO21551.1 - 1.2e-06 28.0 0.0 0.19 11.1 0.0 3.5 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KOO21551.1 - 1.6e-06 28.5 0.0 0.36 11.3 0.0 3.5 3 0 0 3 3 3 2 RNA helicase ClpB_D2-small PF10431.9 KOO21551.1 - 1.6e-06 28.1 0.0 5.2e-06 26.4 0.0 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_7 PF12775.7 KOO21551.1 - 2.1e-06 27.4 0.0 0.011 15.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 KOO21551.1 - 2.1e-06 27.8 0.0 0.019 15.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 KOO21551.1 - 6.4e-06 26.2 0.1 1.9 8.3 0.0 3.6 3 1 0 3 3 3 2 ATPase domain predominantly from Archaea AAA_23 PF13476.6 KOO21551.1 - 6.8e-06 26.7 0.4 0.098 13.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 KOO21551.1 - 1.3e-05 25.8 0.1 0.05 14.2 0.0 3.1 3 0 0 3 3 2 1 AAA domain Roc PF08477.13 KOO21551.1 - 2.8e-05 24.3 0.0 0.085 13.1 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 KOO21551.1 - 4.7e-05 23.9 0.2 0.0084 16.6 0.0 3.2 3 0 0 3 3 3 1 ABC transporter TsaE PF02367.17 KOO21551.1 - 0.00012 22.1 0.0 0.38 10.8 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 KOO21551.1 - 0.00012 21.8 1.8 0.46 10.2 0.0 3.7 3 1 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain RsgA_GTPase PF03193.16 KOO21551.1 - 0.00014 21.8 0.0 0.21 11.5 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_19 PF13245.6 KOO21551.1 - 0.00015 22.1 0.0 0.43 10.9 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 KOO21551.1 - 0.00015 21.9 3.6 0.092 12.9 0.0 3.7 3 1 0 3 3 2 1 AAA domain AAA_3 PF07726.11 KOO21551.1 - 0.0002 21.2 0.2 0.26 11.1 0.1 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOO21551.1 - 0.00058 19.8 0.0 0.47 10.4 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 KOO21551.1 - 0.00063 19.5 0.0 0.94 9.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 KOO21551.1 - 0.0017 18.0 5.2 0.13 11.8 0.0 3.8 5 0 0 5 5 3 1 AAA domain AAA_28 PF13521.6 KOO21551.1 - 0.0023 18.2 7.6 0.37 11.0 0.0 4.1 3 1 0 3 3 2 2 AAA domain NTPase_1 PF03266.15 KOO21551.1 - 0.0024 17.8 0.0 2.5 8.0 0.0 2.6 2 0 0 2 2 2 1 NTPase SRP54 PF00448.22 KOO21551.1 - 0.0027 17.4 0.0 0.26 10.9 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 KOO21551.1 - 0.0029 16.9 0.8 0.34 10.2 0.0 2.7 3 0 0 3 3 2 1 Zeta toxin DUF815 PF05673.13 KOO21551.1 - 0.0035 16.6 3.6 0.24 10.5 0.0 3.3 3 1 0 3 3 2 1 Protein of unknown function (DUF815) MCM PF00493.23 KOO21551.1 - 0.0049 16.0 0.1 0.46 9.5 0.1 2.7 2 1 0 2 2 2 1 MCM P-loop domain ResIII PF04851.15 KOO21551.1 - 0.0061 16.6 0.0 3.3 7.7 0.0 3.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Torsin PF06309.11 KOO21551.1 - 0.0082 16.2 0.0 0.044 13.9 0.0 2.1 2 0 0 2 2 2 1 Torsin PduV-EutP PF10662.9 KOO21551.1 - 0.0096 15.7 0.0 0.17 11.6 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 KOO21551.1 - 0.0097 15.7 0.0 6.6 6.4 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 KOO21551.1 - 0.013 15.6 0.0 2 8.6 0.0 2.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase Bac_DnaA PF00308.18 KOO21551.1 - 0.013 15.4 0.0 2.9 7.7 0.0 2.5 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_29 PF13555.6 KOO21551.1 - 0.015 15.0 0.0 3.7 7.3 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain T2SSE PF00437.20 KOO21551.1 - 0.016 14.3 0.0 0.086 11.9 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein Ras PF00071.22 KOO21551.1 - 0.037 13.6 0.0 4 7.0 0.0 2.3 2 0 0 2 2 2 0 Ras family Borrelia_P83 PF05262.11 KOO21551.1 - 0.074 11.5 6.4 0.13 10.7 6.4 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Rad17 PF03215.15 KOO21551.1 - 0.093 12.6 0.0 12 5.7 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain DAHP_snth_FXD PF18152.1 KOO21551.1 - 0.11 12.4 0.1 0.44 10.4 0.1 2.1 2 0 0 2 2 1 0 DAHP synthase ferredoxin-like domain AAA_21 PF13304.6 KOO21551.1 - 0.16 11.7 0.0 6.9 6.4 0.0 3.1 3 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system CLP1_P PF16575.5 KOO21551.1 - 0.16 11.7 0.0 0.88 9.3 0.0 2.1 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF4407 PF14362.6 KOO21551.1 - 0.51 9.7 7.4 0.9 8.8 7.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OEP PF02321.18 KOO21551.1 - 0.96 9.2 13.4 2.4 7.9 13.4 1.6 1 0 0 1 1 1 0 Outer membrane efflux protein OmpH PF03938.14 KOO21551.1 - 1.5 9.1 7.5 4.9 7.5 7.5 1.9 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) UPF0242 PF06785.11 KOO21551.1 - 2.2 8.4 6.5 4.6 7.3 6.5 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AAA_17 PF13207.6 KOO21551.1 - 7.3 7.0 6.9 45 4.5 0.5 3.7 3 2 0 3 3 3 0 AAA domain Peptidase_M16_C PF05193.21 KOO21553.1 - 3.3e-31 108.7 0.0 6e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOO21553.1 - 2.7e-27 95.6 0.2 4.6e-27 94.8 0.2 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) HhH-GPD PF00730.25 KOO21554.1 - 1.2e-12 48.2 0.0 1.6e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KOO21554.1 - 2e-07 30.5 0.0 3.6e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 KOO21554.1 - 0.033 14.8 0.1 0.19 12.4 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix domain Orn_Arg_deC_N PF02784.16 KOO21555.1 - 9.9e-64 215.1 0.0 2.1e-63 214.0 0.0 1.5 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 KOO21555.1 - 1.2e-11 44.7 0.0 4.6e-11 42.8 0.0 2.1 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain CMD PF02627.20 KOO21555.1 - 0.055 13.5 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family Init_tRNA_PT PF04179.12 KOO21555.1 - 0.072 13.4 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain AdoHcyase PF05221.17 KOO21555.1 - 0.096 11.8 0.9 0.16 11.1 0.9 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase HTH_30 PF13556.6 KOO21555.1 - 0.13 12.1 0.1 0.28 11.0 0.1 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain EXS PF03124.14 KOO21556.1 - 1.4e-73 248.1 8.9 1.4e-73 248.1 8.9 1.4 2 0 0 2 2 2 1 EXS family PARP PF00644.20 KOO21557.1 - 1.1e-15 57.8 0.0 3.5e-15 56.1 0.0 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain MHB PF16525.5 KOO21557.1 - 0.0042 17.3 0.0 0.84 9.9 0.0 2.6 2 0 0 2 2 2 2 Haemophore, haem-binding AAA_11 PF13086.6 KOO21558.1 - 4.2e-16 59.5 0.1 8.8e-08 32.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 KOO21558.1 - 4.2e-05 23.3 0.0 7.4e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO21558.1 - 0.0084 15.8 0.1 0.026 14.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain Zn_Tnp_IS1595 PF12760.7 KOO21558.1 - 0.052 13.5 2.2 0.81 9.7 1.7 2.7 2 0 0 2 2 2 0 Transposase zinc-ribbon domain AAA_19 PF13245.6 KOO21558.1 - 0.14 12.5 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 KOO21559.1 - 2.8e-56 191.2 0.0 3.4e-43 148.1 0.0 2.1 1 1 1 2 2 2 2 Predicted ATPase of the ABC class Pkinase_Tyr PF07714.17 KOO21559.1 - 3.6e-07 29.7 0.0 6.1e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO21559.1 - 0.0001 21.8 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Birna_VP4 PF01768.16 KOO21559.1 - 0.036 13.9 0.2 0.059 13.2 0.2 1.2 1 0 0 1 1 1 0 Birnavirus VP4 protein PQ-loop PF04193.14 KOO21560.1 - 1.2e-08 34.6 0.2 2.8e-08 33.4 0.0 1.7 2 0 0 2 2 2 1 PQ loop repeat DUF4235 PF14019.6 KOO21561.1 - 0.0099 15.9 2.6 0.025 14.6 2.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4235) EF-hand_6 PF13405.6 KOO21562.1 - 2.1e-25 86.4 2.5 2.6e-05 23.8 0.0 6.5 5 1 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 KOO21562.1 - 2.1e-23 80.1 3.5 1.1e-05 24.6 0.2 6.4 5 1 1 6 6 6 3 EF hand EF-hand_7 PF13499.6 KOO21562.1 - 7.7e-20 71.1 5.3 9.1e-06 26.0 0.2 4.8 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO21562.1 - 1.4e-16 59.1 7.3 0.00032 20.0 0.1 6.1 7 0 0 7 7 7 3 EF hand EF-hand_8 PF13833.6 KOO21562.1 - 6.5e-14 51.5 4.2 0.0097 15.7 0.0 5.3 4 1 1 5 5 5 4 EF-hand domain pair DUF4473 PF14747.6 KOO21562.1 - 0.0002 21.8 0.0 0.012 16.2 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4473) SPARC_Ca_bdg PF10591.9 KOO21562.1 - 0.0041 17.4 0.3 4.6 7.6 0.0 4.1 3 2 1 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO21562.1 - 0.011 16.1 1.3 94 3.5 0.0 5.0 7 0 0 7 7 7 0 EF-hand domain EF-hand_4 PF12763.7 KOO21562.1 - 0.029 14.3 7.9 1.8 8.5 0.1 4.6 3 2 2 5 5 5 0 Cytoskeletal-regulatory complex EF hand Cas9_b_hairpin PF17893.1 KOO21562.1 - 0.036 13.9 0.2 0.44 10.4 0.0 2.8 3 0 0 3 3 3 0 CRISPR-associated endonuclease Cas9 beta-hairpin domain CA_like PF10563.9 KOO21563.1 - 1.7e-58 197.5 2.1 3e-58 196.7 2.1 1.4 1 0 0 1 1 1 1 Putative carbonic anhydrase Acetyltransf_1 PF00583.25 KOO21563.1 - 0.00047 20.4 0.2 0.0016 18.7 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 KOO21563.1 - 0.045 14.4 0.0 0.1 13.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Nucleotid_trans PF03407.16 KOO21563.1 - 0.056 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Sigma_reg_N PF13800.6 KOO21563.1 - 9.7 6.6 5.7 0.92 9.8 0.1 2.2 3 0 0 3 3 3 0 Sigma factor regulator N-terminal PBP PF01161.20 KOO21565.1 - 1.4e-06 28.6 0.0 2.5e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein FA_desaturase PF00487.24 KOO21566.1 - 5.9e-19 68.9 12.5 8.5e-19 68.4 12.5 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 KOO21566.1 - 9.1e-07 28.9 0.0 2.1e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DinB_2 PF12867.7 KOO21566.1 - 0.47 11.0 7.0 3.3 8.2 0.1 3.3 3 0 0 3 3 3 0 DinB superfamily YccV-like PF08755.11 KOO21567.1 - 2.4e-15 56.8 0.0 4.1e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like PRKCSH PF07915.13 KOO21567.1 - 3e-08 34.6 9.0 1e-07 32.9 8.9 1.7 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 KOO21567.1 - 4.2e-06 26.5 1.2 6.5e-06 25.9 1.2 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein UBA PF00627.31 KOO21568.1 - 5.7e-07 29.3 0.2 1.7e-06 27.8 0.2 1.8 1 0 0 1 1 1 1 UBA/TS-N domain TPR_2 PF07719.17 KOO21568.1 - 0.052 13.7 3.4 4.1 7.8 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21568.1 - 0.24 11.9 0.1 0.24 11.9 0.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF952 PF06108.12 KOO21569.1 - 8.9e-07 28.8 0.0 1.3e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF952) Kinesin PF00225.23 KOO21570.1 - 1e-99 333.7 0.1 1.2e-99 333.4 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO21570.1 - 2.9e-21 76.0 0.0 5.3e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Septin PF00735.18 KOO21571.1 - 5.3e-51 173.5 0.0 1e-50 172.6 0.0 1.4 1 1 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KOO21571.1 - 9.5e-05 22.5 0.0 0.00015 21.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase TsaE PF02367.17 KOO21571.1 - 0.0038 17.2 0.0 0.011 15.7 0.0 1.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pox_A32 PF04665.12 KOO21571.1 - 0.0065 16.0 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Poxvirus A32 protein AAA_22 PF13401.6 KOO21571.1 - 0.0068 16.7 0.0 0.023 15.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO21571.1 - 0.0073 16.7 0.0 0.023 15.1 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 KOO21571.1 - 0.01 15.5 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 KOO21571.1 - 0.069 12.9 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 KOO21571.1 - 0.073 13.2 0.1 0.32 11.1 0.1 2.0 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 KOO21571.1 - 0.088 13.3 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 KOO21571.1 - 0.094 12.2 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Roc PF08477.13 KOO21571.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 KOO21571.1 - 0.12 12.3 0.0 0.62 9.9 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_5 PF07728.14 KOO21571.1 - 0.15 12.0 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 KOO21571.1 - 0.23 10.6 0.0 0.41 9.7 0.0 1.3 1 1 0 1 1 1 0 G-protein alpha subunit Form_Nir_trans PF01226.17 KOO21572.1 - 7.8e-65 218.5 23.7 9.1e-65 218.3 23.7 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter PHO4 PF01384.20 KOO21573.1 - 6.7e-76 255.5 19.8 2.2e-75 253.8 19.8 1.7 1 1 0 1 1 1 1 Phosphate transporter family Chloroa_b-bind PF00504.21 KOO21574.1 - 6.4e-26 91.8 0.0 8.7e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Mito_carr PF00153.27 KOO21575.1 - 4.6e-40 135.5 7.4 3.4e-17 62.2 0.3 3.0 1 1 2 3 3 3 3 Mitochondrial carrier protein TSNAXIP1_N PF15739.5 KOO21576.1 - 1.5e-07 31.8 7.2 1.8e-06 28.3 1.5 3.7 1 1 1 2 2 2 1 Translin-associated factor X-interacting N-terminus Filament PF00038.21 KOO21576.1 - 0.00015 21.5 14.0 0.00029 20.5 14.0 1.4 1 0 0 1 1 1 1 Intermediate filament protein NleF_casp_inhib PF16809.5 KOO21576.1 - 0.058 13.3 2.0 0.16 11.9 2.0 1.7 1 0 0 1 1 1 0 NleF caspase inhibitor 3-PAP PF12578.8 KOO21576.1 - 0.15 11.8 5.2 2.8 7.7 0.0 4.0 3 1 1 4 4 4 0 Myotubularin-associated protein SHE3 PF17078.5 KOO21576.1 - 0.49 10.1 11.3 2.5 7.8 11.1 2.2 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 CENP-F_leu_zip PF10473.9 KOO21576.1 - 4.2 7.4 23.7 0.44 10.6 13.9 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 KOO21576.1 - 4.3 6.1 14.1 9.3 5.0 14.1 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein Fez1 PF06818.15 KOO21576.1 - 10 6.5 19.2 2.4 8.5 3.3 2.3 1 1 1 2 2 2 0 Fez1 EF-hand_1 PF00036.32 KOO21577.1 - 6.9e-16 56.5 1.6 0.00012 21.4 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO21577.1 - 3.8e-14 51.3 2.0 0.00044 20.0 0.1 3.9 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 KOO21577.1 - 4.3e-13 49.5 2.4 1.8e-07 31.5 0.4 3.3 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO21577.1 - 8.7e-05 22.3 4.3 0.54 10.2 0.1 3.9 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO21577.1 - 0.00063 19.7 4.1 0.072 13.1 0.1 3.2 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 KOO21577.1 - 0.0092 15.4 2.1 4.3 7.0 0.0 3.4 4 0 0 4 4 4 2 EF hand RecG_N PF17190.4 KOO21577.1 - 0.012 16.3 0.0 0.15 12.8 0.0 2.4 3 1 0 3 3 3 0 RecG N-terminal helical domain Pox_D5 PF03288.16 KOO21577.1 - 0.016 15.7 0.4 1.2 9.6 0.0 2.8 3 0 0 3 3 3 0 Poxvirus D5 protein-like Prot_ATP_ID_OB PF16450.5 KOO21578.1 - 0.028 14.4 0.0 0.041 13.8 0.0 1.6 1 1 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain Thioredoxin PF00085.20 KOO21580.1 - 5.1e-18 65.0 0.0 1.8e-17 63.2 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin Glyoxalase PF00903.25 KOO21580.1 - 2.5e-05 24.5 0.0 0.27 11.5 0.0 3.5 3 1 0 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Thioredoxin_9 PF14595.6 KOO21580.1 - 3.8e-05 23.5 0.0 6.3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KOO21580.1 - 5e-05 23.5 0.0 0.015 15.6 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_3 PF13192.6 KOO21580.1 - 0.0015 18.5 0.0 0.0031 17.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin domain OST3_OST6 PF04756.13 KOO21580.1 - 0.0041 16.5 0.0 0.0057 16.0 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Glyoxalase_6 PF18029.1 KOO21580.1 - 0.0054 17.5 0.0 0.29 12.0 0.0 3.0 2 1 0 2 2 2 1 Glyoxalase-like domain Thioredoxin_2 PF13098.6 KOO21580.1 - 0.0058 17.1 0.1 0.053 14.0 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain DIM1 PF02966.16 KOO21580.1 - 0.19 11.5 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 GNT-I PF03071.15 KOO21581.1 - 1.9e-59 201.5 0.0 2.7e-59 201.1 0.0 1.1 1 0 0 1 1 1 1 GNT-I family Glyco_transf_18 PF15024.6 KOO21581.1 - 0.00036 19.3 2.9 0.00053 18.7 2.9 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 18 Glyco_tranf_2_3 PF13641.6 KOO21581.1 - 0.00053 19.9 0.0 0.0042 17.0 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 MORN PF02493.20 KOO21582.1 - 2e-23 80.8 31.9 9.2e-06 25.3 2.1 5.2 5 0 0 5 5 5 5 MORN repeat EF-hand_6 PF13405.6 KOO21583.1 - 6.7e-15 53.7 0.8 0.00011 21.9 0.2 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO21583.1 - 3.9e-14 51.0 1.8 0.00099 18.5 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO21583.1 - 9.6e-11 41.4 1.3 0.019 14.8 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 KOO21583.1 - 9.1e-10 38.9 2.6 6.6e-05 23.3 1.8 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO21583.1 - 1.4e-07 30.7 3.6 0.036 13.6 0.3 3.6 3 0 0 3 3 3 3 EF hand EF-hand_14 PF17959.1 KOO21583.1 - 0.00039 20.7 0.4 0.82 10.1 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain Homoserine_dh PF00742.19 KOO21584.1 - 0.12 12.3 1.5 0.16 11.8 1.5 1.3 1 1 0 1 1 1 0 Homoserine dehydrogenase Herpes_UL25 PF01499.16 KOO21584.1 - 3.4 6.1 6.6 4 5.8 6.6 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family DUF3645 PF12359.8 KOO21586.1 - 7.1e-15 54.1 0.2 6.7e-14 51.0 0.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) Thioredoxin_8 PF13905.6 KOO21586.1 - 6.6e-11 42.4 0.0 1.5e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like C1_2 PF03107.16 KOO21586.1 - 1.1e-05 25.7 8.1 1.1e-05 25.7 8.1 2.0 2 0 0 2 2 2 1 C1 domain FYVE PF01363.21 KOO21586.1 - 2.1 8.5 6.4 0.26 11.5 1.7 1.9 2 0 0 2 2 2 0 FYVE zinc finger Pkinase PF00069.25 KOO21587.1 - 5.3e-42 144.0 0.0 7.1e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21587.1 - 5.5e-28 98.0 0.0 7.7e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO21587.1 - 0.015 15.2 0.1 0.032 14.2 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 KOO21587.1 - 0.03 13.9 0.3 0.24 10.9 0.0 2.0 1 1 1 2 2 2 0 RIO1 family PIP49_C PF12260.8 KOO21587.1 - 0.18 11.4 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 C2 PF00168.30 KOO21588.1 - 2e-05 24.8 0.0 0.00025 21.3 0.0 2.4 1 1 0 1 1 1 1 C2 domain V-SNARE_C PF12352.8 KOO21588.1 - 0.0002 21.6 1.9 0.00033 20.9 0.7 1.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Fn_bind PF02986.14 KOO21588.1 - 0.072 12.8 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 Fibronectin binding repeat DnaJ PF00226.31 KOO21590.1 - 1e-19 70.4 0.6 2.1e-19 69.4 0.2 1.7 1 1 1 2 2 2 1 DnaJ domain MORN PF02493.20 KOO21590.1 - 1.9e-08 33.7 1.4 0.0095 15.8 0.1 3.5 3 0 0 3 3 3 2 MORN repeat Fer2 PF00111.27 KOO21590.1 - 0.074 13.0 0.4 0.15 12.1 0.4 1.5 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain DUF617 PF04759.13 KOO21590.1 - 0.094 12.8 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF617 MIB_HERC2 PF06701.13 KOO21591.1 - 5.7e-06 26.5 4.3 1.3e-05 25.4 4.3 1.6 1 0 0 1 1 1 1 Mib_herc2 EF-hand_5 PF13202.6 KOO21591.1 - 0.00033 20.0 0.4 0.0011 18.3 0.1 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO21591.1 - 0.00062 19.5 0.2 0.0021 17.8 0.2 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO21591.1 - 0.0079 15.7 0.9 0.021 14.3 0.2 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO21591.1 - 0.051 14.0 0.1 0.23 12.0 0.1 2.1 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 KOO21591.1 - 0.19 11.6 0.2 0.54 10.1 0.1 1.8 2 0 0 2 2 2 0 EF-hand domain pair Bestrophin PF01062.21 KOO21592.1 - 1.5e-15 57.4 0.0 3.7e-15 56.1 0.0 1.5 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel P68HR PF08061.11 KOO21593.1 - 3 8.1 4.4 0.81 9.9 0.9 1.8 2 0 0 2 2 2 0 P68HR (NUC004) repeat DUF4407 PF14362.6 KOO21594.1 - 0.0065 15.9 14.1 0.0065 15.9 14.1 2.8 2 1 0 3 3 3 1 Domain of unknown function (DUF4407) Pkinase PF00069.25 KOO21595.1 - 1.3e-17 64.0 0.0 3.6e-17 62.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21595.1 - 6.4e-16 58.4 0.0 7.8e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO21595.1 - 0.0012 18.8 0.8 0.029 14.3 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family ABC_tran PF00005.27 KOO21596.1 - 3.8e-47 160.3 0.0 3.1e-27 95.8 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 KOO21596.1 - 8.3e-31 107.6 27.8 1.1e-19 71.2 15.4 2.5 3 0 0 3 3 2 2 ABC transporter transmembrane region SMC_N PF02463.19 KOO21596.1 - 8.2e-08 32.0 1.4 0.38 10.1 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KOO21596.1 - 1.1e-05 25.4 0.4 0.001 19.0 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KOO21596.1 - 4.5e-05 23.9 0.1 0.39 11.1 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 KOO21596.1 - 5.5e-05 23.2 2.6 0.19 11.8 0.6 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 KOO21596.1 - 0.00042 20.0 0.6 0.75 9.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO21596.1 - 0.0008 19.7 0.3 4.4 7.6 0.1 3.3 3 0 0 3 3 3 2 AAA domain FtsK_SpoIIIE PF01580.18 KOO21596.1 - 0.0014 18.1 0.3 0.19 11.1 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_7 PF12775.7 KOO21596.1 - 0.0015 18.1 0.7 1 8.8 0.1 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region Dynamin_N PF00350.23 KOO21596.1 - 0.0016 18.5 0.9 0.12 12.4 0.1 2.5 2 0 0 2 2 2 1 Dynamin family T2SSE PF00437.20 KOO21596.1 - 0.0024 17.0 0.3 0.055 12.5 0.0 2.8 2 1 1 3 3 3 1 Type II/IV secretion system protein NB-ARC PF00931.22 KOO21596.1 - 0.0029 16.8 2.6 0.96 8.6 0.2 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_21 PF13304.6 KOO21596.1 - 0.0041 17.0 0.0 1.2 8.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KOO21596.1 - 0.0048 16.7 0.0 0.96 9.1 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain DEAD PF00270.29 KOO21596.1 - 0.0092 15.8 1.9 0.061 13.1 0.8 2.5 2 1 0 2 2 2 1 DEAD/DEAH box helicase TrwB_AAD_bind PF10412.9 KOO21596.1 - 0.0096 14.9 1.1 0.66 8.8 0.1 2.2 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain Roc PF08477.13 KOO21596.1 - 0.014 15.6 0.5 2.4 8.4 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 KOO21596.1 - 0.019 14.7 7.9 0.73 9.5 0.0 3.3 4 0 0 4 4 3 0 AAA domain NACHT PF05729.12 KOO21596.1 - 0.029 14.3 1.2 5.4 6.9 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.6 KOO21596.1 - 0.031 14.8 0.0 1.2 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 KOO21596.1 - 0.043 13.9 4.2 0.3 11.1 0.1 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain cobW PF02492.19 KOO21596.1 - 0.067 12.8 1.7 2.9 7.4 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain KAP_NTPase PF07693.14 KOO21596.1 - 0.091 12.0 0.0 1.4 8.1 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain AAA_24 PF13479.6 KOO21596.1 - 0.12 12.0 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 KOO21596.1 - 0.15 11.0 2.0 1.7 7.6 0.1 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 KOO21596.1 - 0.17 12.4 0.1 15 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 KOO21596.1 - 0.17 11.6 1.6 2 8.1 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.6 KOO21596.1 - 0.18 12.1 1.1 16 5.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 KOO21596.1 - 0.22 11.0 1.6 0.26 10.7 0.2 1.7 2 0 0 2 2 2 0 Poxvirus A32 protein TsaE PF02367.17 KOO21596.1 - 0.24 11.4 0.4 27 4.8 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 KOO21596.1 - 1.3 8.9 6.0 11 5.9 0.2 3.2 3 0 0 3 3 3 0 NTPase DnaI_N PF07319.11 KOO21597.1 - 0.27 11.9 1.5 2.1 9.1 0.4 2.7 3 0 0 3 3 3 0 Primosomal protein DnaI N-terminus OrfB_IS605 PF01385.19 KOO21597.1 - 5.6 7.2 10.3 2.1 8.6 0.5 2.6 1 1 1 2 2 2 0 Probable transposase IQ PF00612.27 KOO21597.1 - 8.6 6.5 16.3 3.5 7.7 1.0 3.4 3 0 0 3 3 3 0 IQ calmodulin-binding motif PUF PF00806.19 KOO21598.1 - 4.1e-47 155.3 0.1 1.3e-05 24.6 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Sacchrp_dh_NADP PF03435.18 KOO21598.1 - 0.0088 16.3 0.1 0.55 10.5 0.0 2.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain MDFI PF15316.6 KOO21598.1 - 0.081 13.0 1.3 6.1 6.9 0.1 2.4 2 0 0 2 2 2 0 MyoD family inhibitor ubiquitin PF00240.23 KOO21599.1 - 1.6e-10 40.6 0.0 0.001 18.7 0.0 3.4 3 0 0 3 3 3 3 Ubiquitin family RCC1 PF00415.18 KOO21600.1 - 1.1e-35 121.9 3.7 1.2e-08 35.4 0.3 4.2 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO21600.1 - 4.6e-13 48.6 18.7 2.2e-07 30.5 1.4 4.9 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat ETF_QO PF05187.13 KOO21601.1 - 1.4e-46 156.9 0.1 2e-46 156.4 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S NAD_binding_8 PF13450.6 KOO21601.1 - 9.4e-08 32.2 0.1 5.2e-07 29.8 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO21601.1 - 1.2e-07 31.7 0.1 2.3e-05 24.2 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 KOO21601.1 - 3.4e-05 23.3 0.1 6.1e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 KOO21601.1 - 3.7e-05 23.1 0.0 0.0012 18.1 0.1 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 KOO21601.1 - 4.5e-05 22.7 0.8 0.0031 16.6 0.4 2.1 1 1 1 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 KOO21601.1 - 0.00025 21.6 0.3 0.16 12.6 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.7 KOO21601.1 - 0.00034 21.1 3.5 0.00069 20.2 3.5 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain NAD_binding_9 PF13454.6 KOO21601.1 - 0.00062 19.8 0.1 0.0014 18.7 0.1 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 KOO21601.1 - 0.001 18.3 0.0 0.0015 17.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO21601.1 - 0.0013 17.5 0.2 0.0021 16.8 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein Fer4_9 PF13187.6 KOO21601.1 - 0.0017 18.5 3.3 0.0036 17.4 3.3 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 KOO21601.1 - 0.0023 18.4 1.1 0.0049 17.4 1.1 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Trp_halogenase PF04820.14 KOO21601.1 - 0.003 16.5 0.9 0.0063 15.4 0.1 1.8 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.7 KOO21601.1 - 0.01 15.2 0.1 0.016 14.5 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Fer4_21 PF14697.6 KOO21601.1 - 0.016 15.4 1.9 0.035 14.2 1.9 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 KOO21601.1 - 0.021 14.9 2.2 0.056 13.6 2.2 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain Pyr_redox_3 PF13738.6 KOO21601.1 - 0.038 13.2 0.2 0.059 12.6 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_10 PF13237.6 KOO21601.1 - 0.056 13.6 5.8 0.064 13.4 4.1 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4 PF00037.27 KOO21601.1 - 0.11 12.4 3.7 0.064 13.1 1.6 1.8 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.7 KOO21601.1 - 0.88 9.8 4.7 0.5 10.5 2.4 1.8 2 0 0 2 2 2 0 4Fe-4S binding domain DUF2040 PF09745.9 KOO21602.1 - 1.7e-27 95.9 21.6 1.7e-27 95.9 21.6 1.9 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) ATP_bind_1 PF03029.17 KOO21603.1 - 7.3e-43 147.1 0.0 1e-42 146.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein SSF PF00474.17 KOO21603.1 - 7.8e-16 57.9 30.6 4.3e-15 55.5 30.6 1.9 1 1 0 1 1 1 1 Sodium:solute symporter family CCB1 PF12046.8 KOO21603.1 - 0.1 11.9 0.0 0.1 11.9 0.0 3.0 3 0 0 3 3 3 0 Cofactor assembly of complex C subunit B EF-hand_6 PF13405.6 KOO21604.1 - 1.2e-21 74.7 5.3 6.3e-05 22.6 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO21604.1 - 2.7e-20 70.3 7.6 0.00035 19.9 0.6 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO21604.1 - 2.4e-14 53.6 5.3 8.2e-05 23.0 0.3 4.0 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO21604.1 - 3.6e-14 52.3 4.9 4.4e-06 26.4 0.2 3.8 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO21604.1 - 1e-13 50.1 10.8 0.0033 16.9 0.2 4.5 4 0 0 4 4 4 4 EF hand p25-alpha PF05517.12 KOO21604.1 - 0.0012 19.0 0.8 1.5 9.0 0.3 2.6 2 0 0 2 2 2 2 p25-alpha DUF2666 PF10869.8 KOO21604.1 - 0.014 15.6 1.4 0.049 13.8 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) EF-hand_4 PF12763.7 KOO21604.1 - 0.032 14.2 1.4 4.4 7.3 0.0 3.2 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 KOO21604.1 - 0.14 12.1 0.2 24 4.8 0.0 3.5 2 2 2 4 4 4 0 Caleosin related protein EF-hand_10 PF14788.6 KOO21604.1 - 0.32 10.9 0.8 6.1 6.8 0.1 2.7 3 0 0 3 3 3 0 EF hand DUF3138 PF11336.8 KOO21604.1 - 2.4 6.7 7.3 0.41 9.2 2.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) GTP_EFTU PF00009.27 KOO21605.1 - 6.2e-50 169.4 0.0 8.6e-50 169.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 KOO21605.1 - 2.5e-33 115.2 11.7 4.2e-33 114.5 11.7 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_C PF00679.24 KOO21605.1 - 5.4e-23 80.8 0.0 1.2e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 KOO21605.1 - 3.3e-21 75.3 0.0 5.8e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 KOO21605.1 - 2.1e-11 44.0 0.0 4.9e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOO21605.1 - 1.4e-07 31.6 0.1 2.4e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 KOO21605.1 - 2.4e-05 24.3 0.0 6.3e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Roc PF08477.13 KOO21605.1 - 0.00043 20.5 0.0 0.25 11.6 0.0 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 KOO21605.1 - 0.00091 19.3 0.0 0.54 10.3 0.0 2.3 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 KOO21605.1 - 0.0041 16.6 0.0 1.2 8.6 0.0 2.4 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit Ras PF00071.22 KOO21605.1 - 0.0087 15.7 0.0 0.086 12.4 0.0 2.1 2 0 0 2 2 2 1 Ras family Septin PF00735.18 KOO21605.1 - 0.021 14.1 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Septin Pes-10 PF07149.11 KOO21605.1 - 0.16 11.0 2.7 0.25 10.4 2.7 1.1 1 0 0 1 1 1 0 Pes-10 TIG PF01833.24 KOO21607.1 - 3.4e-26 91.1 6.8 1.7e-09 37.6 0.9 4.1 4 0 0 4 4 4 3 IPT/TIG domain TIG_plexin PF17960.1 KOO21607.1 - 5.5e-07 29.5 0.0 0.53 10.3 0.0 3.6 4 0 0 4 4 4 3 TIG domain DENN PF02141.21 KOO21608.1 - 7.1e-37 127.2 1.9 1.3e-36 126.3 1.9 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain Lipase_3 PF01764.25 KOO21608.1 - 0.0026 17.6 0.0 0.0094 15.8 0.0 1.9 2 0 0 2 2 2 1 Lipase (class 3) dDENN PF03455.19 KOO21608.1 - 0.15 12.1 0.1 0.55 10.3 0.1 2.1 1 0 0 1 1 1 0 dDENN domain V-ATPase_H_N PF03224.14 KOO21609.1 - 4.3e-57 193.8 0.0 2e-55 188.3 0.0 2.0 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 KOO21609.1 - 6.6e-42 142.3 0.0 2e-39 134.3 0.0 2.5 2 0 0 2 2 2 2 V-ATPase subunit H Arm PF00514.23 KOO21609.1 - 6.5e-13 48.2 6.1 0.014 15.4 0.0 5.7 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat DRIM PF07539.12 KOO21609.1 - 0.00035 19.0 1.6 0.3 9.3 0.0 2.3 2 0 0 2 2 2 2 Down-regulated in metastasis HEAT_2 PF13646.6 KOO21609.1 - 0.00058 20.2 0.5 1.3 9.4 0.0 3.2 3 0 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 KOO21609.1 - 0.05 14.1 0.6 14 6.3 0.0 3.9 4 0 0 4 4 4 0 HEAT-like repeat HEAT PF02985.22 KOO21609.1 - 0.084 13.2 0.0 55 4.4 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat zf-DNL PF05180.12 KOO21610.1 - 7.4e-27 93.1 0.3 1.1e-26 92.5 0.3 1.3 1 0 0 1 1 1 1 DNL zinc finger Elf1 PF05129.13 KOO21610.1 - 0.0047 17.0 0.3 0.0077 16.3 0.3 1.3 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like RuvA_C PF07499.13 KOO21610.1 - 0.067 13.7 0.2 1.7 9.2 0.0 2.4 2 0 0 2 2 2 0 RuvA, C-terminal domain Calpain_III PF01067.22 KOO21611.1 - 3.1e-16 59.9 0.0 9.7e-06 25.9 0.0 4.2 4 0 0 4 4 4 4 Calpain large subunit, domain III Peptidase_C2 PF00648.21 KOO21611.1 - 1.5e-14 53.8 0.0 7.4e-14 51.5 0.0 1.9 1 1 0 1 1 1 1 Calpain family cysteine protease NAD_binding_5 PF07994.12 KOO21612.1 - 7.1e-41 140.6 0.0 1.2e-40 139.8 0.0 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 KOO21612.1 - 1.7e-27 95.8 0.0 2.6e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase PfkB PF00294.24 KOO21612.1 - 9.1e-19 67.9 0.0 1.9e-18 66.8 0.0 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Med4 PF10018.9 KOO21612.1 - 0.0035 17.1 0.1 0.017 14.8 0.1 1.9 1 1 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 Dak2 PF02734.17 KOO21612.1 - 0.23 11.4 7.1 5.3 6.9 0.2 3.0 2 1 0 2 2 2 0 DAK2 domain DUF2563 PF10817.8 KOO21612.1 - 0.4 11.3 5.1 2.8 8.6 4.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2563) DNA_methylase PF00145.17 KOO21614.1 - 1.7e-12 47.4 0.0 5.7e-09 35.8 0.0 2.0 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase Ank_2 PF12796.7 KOO21615.1 - 1.8e-10 41.3 2.6 2.2e-05 25.0 0.7 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO21615.1 - 9.8e-08 32.1 8.0 0.038 14.4 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KOO21615.1 - 1.7e-07 31.6 0.5 0.0015 19.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO21615.1 - 3.7e-06 27.1 0.2 0.036 14.4 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO21615.1 - 0.006 17.0 0.0 12 6.8 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat PNRC PF15365.6 KOO21615.1 - 3.1 7.7 6.7 9.2 6.2 6.7 1.9 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator motif AA_kinase PF00696.28 KOO21617.1 - 6.3e-41 140.6 2.8 7e-41 140.4 2.8 1.0 1 0 0 1 1 1 1 Amino acid kinase family MinC_N PF05209.13 KOO21617.1 - 0.099 12.6 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Septum formation inhibitor MinC, N-terminal domain PSII_BNR PF14870.6 KOO21618.1 - 0.00012 21.4 4.7 0.016 14.5 0.3 3.4 3 1 1 4 4 4 2 Photosynthesis system II assembly factor YCF48 Sortilin-Vps10 PF15902.5 KOO21618.1 - 0.0037 16.1 1.5 0.38 9.5 0.1 2.7 3 1 1 4 4 4 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KOO21618.1 - 0.022 14.7 13.4 8 6.9 2.5 5.5 5 0 0 5 5 5 0 BNR/Asp-box repeat Neur_chan_memb PF02932.16 KOO21619.1 - 7.6e-06 26.2 0.4 1.1e-05 25.6 0.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Annexin PF00191.20 KOO21620.1 - 3.4e-72 238.4 11.3 2.9e-15 56.1 0.2 8.4 8 0 0 8 8 8 8 Annexin EF-hand_6 PF13405.6 KOO21621.1 - 2.8e-09 36.2 1.1 0.0024 17.7 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO21621.1 - 1.2e-08 33.8 0.3 0.0034 16.8 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO21621.1 - 1.3e-08 35.2 3.1 1.9e-06 28.2 0.5 1.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO21621.1 - 1.5e-08 33.8 1.8 0.0037 16.7 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21621.1 - 7.6e-05 22.5 0.2 0.12 12.2 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair C2 PF00168.30 KOO21622.1 - 4e-35 120.2 0.0 2.3e-17 63.2 0.0 2.3 2 0 0 2 2 2 2 C2 domain EF-hand_1 PF00036.32 KOO21622.1 - 1e-18 65.4 8.9 7.5e-06 25.1 0.3 4.1 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO21622.1 - 8.3e-18 62.7 3.3 3.4e-05 23.4 0.1 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KOO21622.1 - 1.7e-15 55.7 9.7 8.1e-05 21.9 0.0 3.9 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO21622.1 - 6.1e-14 51.6 5.6 4e-11 42.6 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO21622.1 - 1.1e-11 45.1 8.0 2.8e-09 37.3 1.7 2.6 2 0 0 2 2 2 2 EF-hand domain pair Acyltransf_C PF16076.5 KOO21622.1 - 0.0048 17.0 0.1 0.012 15.6 0.0 1.7 2 0 0 2 2 2 1 Acyltransferase C-terminus EF-hand_4 PF12763.7 KOO21622.1 - 0.032 14.2 5.1 1.2 9.1 0.4 3.0 2 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO21622.1 - 0.22 11.9 0.7 3.2 8.2 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain Ank_2 PF12796.7 KOO21623.1 - 2e-24 86.0 0.6 6.6e-14 52.3 0.4 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO21623.1 - 2e-23 82.4 4.7 3.4e-08 33.9 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO21623.1 - 2.5e-19 69.0 2.9 5.2e-07 29.8 0.0 4.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO21623.1 - 1.7e-14 53.5 2.7 0.026 15.0 0.2 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KOO21623.1 - 2.6e-10 39.6 0.4 0.67 10.7 0.1 5.7 5 0 0 5 5 5 3 Ankyrin repeat VIT1 PF01988.19 KOO21623.1 - 0.22 11.3 3.5 0.5 10.2 3.5 1.6 1 0 0 1 1 1 0 VIT family SH3_15 PF18346.1 KOO21624.1 - 0.015 15.6 2.1 0.077 13.3 2.1 1.9 1 1 0 1 1 1 0 Mind bomb SH3 repeat domain PT PF04886.12 KOO21624.1 - 0.042 13.4 8.1 0.1 12.2 8.1 1.6 1 0 0 1 1 1 0 PT repeat EF-hand_8 PF13833.6 KOO21625.1 - 0.11 12.4 0.1 0.31 10.9 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_7 PF13499.6 KOO21626.1 - 1.8e-08 34.7 0.0 0.0099 16.3 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO21626.1 - 8.1e-05 22.4 0.0 0.11 12.3 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21626.1 - 0.00051 19.8 0.1 0.27 11.2 0.0 4.1 5 0 0 5 5 5 1 EF-hand domain EF-hand_9 PF14658.6 KOO21626.1 - 0.1 12.9 0.0 7.8 6.9 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 KOO21626.1 - 0.11 12.1 0.3 17 5.3 0.1 3.6 4 0 0 4 4 4 0 EF hand Aa_trans PF01490.18 KOO21627.1 - 1.1e-10 40.8 8.7 1.3e-10 40.6 8.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Ilm1 PF10311.9 KOO21627.1 - 0.022 14.4 0.5 0.027 14.1 0.5 1.2 1 0 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 Peptidase_S8 PF00082.22 KOO21628.1 - 7.9e-21 74.6 13.1 3e-18 66.1 13.1 3.2 1 1 0 1 1 1 1 Subtilase family Amino_oxidase PF01593.24 KOO21629.1 - 2.8e-64 218.1 0.4 5e-64 217.2 0.4 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO21629.1 - 1.5e-07 31.5 1.9 3.9e-07 30.2 0.7 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOO21629.1 - 2.9e-06 27.4 1.6 0.0042 17.1 0.2 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.17 KOO21629.1 - 0.0039 16.5 0.4 0.0087 15.3 0.4 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 KOO21629.1 - 0.012 14.9 1.3 0.14 11.4 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOO21629.1 - 0.013 14.8 0.8 0.57 9.4 0.3 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO21629.1 - 0.018 13.8 0.6 3.9 6.1 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.24 KOO21629.1 - 0.083 12.5 7.4 0.21 11.1 7.4 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOO21629.1 - 0.31 11.6 0.8 3.8 8.2 0.2 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Exostosin PF03016.15 KOO21631.1 - 5.1e-12 45.6 0.0 6e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Exostosin family EF-hand_7 PF13499.6 KOO21633.1 - 3.5e-06 27.4 0.4 5.9e-06 26.6 0.4 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO21633.1 - 0.00011 21.9 0.0 0.014 15.3 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO21633.1 - 0.00095 18.6 5.6 0.023 14.2 0.0 2.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO21633.1 - 0.0034 17.2 0.3 0.0079 16.0 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO21633.1 - 0.056 13.0 1.4 0.08 12.5 0.1 2.0 2 0 0 2 2 2 0 EF hand SurA_N_3 PF13624.6 KOO21633.1 - 0.17 11.6 0.1 0.28 11.0 0.1 1.2 1 0 0 1 1 1 0 SurA N-terminal domain Ank_4 PF13637.6 KOO21636.1 - 1.2e-11 44.9 0.3 3.8e-06 27.4 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO21636.1 - 1.3e-11 45.0 0.0 9.1e-07 29.4 0.0 2.5 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO21636.1 - 2.9e-10 39.5 0.5 0.0018 18.6 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOO21636.1 - 1.4e-09 38.0 1.8 4.1e-07 30.2 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO21636.1 - 3.7e-09 36.6 2.9 6.7e-06 26.3 0.2 3.7 3 0 0 3 3 3 2 Ankyrin repeat Band_7 PF01145.25 KOO21638.1 - 1.4e-16 61.0 1.9 1.8e-16 60.6 1.9 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF2408 PF10303.9 KOO21638.1 - 0.06 13.9 0.5 0.15 12.6 0.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) zf-TAZ PF02135.16 KOO21640.1 - 0.00025 21.4 2.0 0.00045 20.6 2.0 1.4 1 0 0 1 1 1 1 TAZ zinc finger RST PF12174.8 KOO21640.1 - 0.021 14.7 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain Band_7 PF01145.25 KOO21642.1 - 3e-22 79.5 0.4 4.6e-22 78.9 0.4 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Flagellar_put PF12611.8 KOO21642.1 - 0.01 15.6 0.4 0.042 13.6 0.4 2.1 1 0 0 1 1 1 0 Putative flagellar DUF1295 PF06966.12 KOO21643.1 - 3.5e-45 154.4 3.7 4e-45 154.2 3.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 KOO21643.1 - 0.0019 18.6 0.1 0.0086 16.5 0.0 2.0 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 KOO21643.1 - 0.085 13.3 0.0 0.25 11.8 0.0 1.9 1 0 0 1 1 1 0 Phospholipid methyltransferase DUF3958 PF13125.6 KOO21645.1 - 0.0071 16.5 7.9 0.011 15.9 7.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3958) KfrA_N PF11740.8 KOO21645.1 - 0.24 12.1 13.4 0.43 11.3 13.4 1.4 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term NDUFB10 PF10249.9 KOO21646.1 - 0.0072 16.8 0.0 0.0099 16.4 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 DAGAT PF03982.13 KOO21647.1 - 4.7e-30 104.5 0.0 6.4e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase DNA_mis_repair PF01119.19 KOO21648.1 - 4.3e-06 26.4 0.0 4.9e-05 23.0 0.0 2.1 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.26 KOO21648.1 - 1.9e-05 25.1 0.0 4.4e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOO21648.1 - 0.00047 20.0 0.1 0.001 18.9 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Copper-fist PF00649.18 KOO21648.1 - 0.037 13.5 0.1 0.096 12.2 0.1 1.6 1 0 0 1 1 1 0 Copper fist DNA binding domain DNA_photolyase PF00875.18 KOO21648.1 - 0.059 13.4 0.2 0.24 11.4 0.1 2.1 2 1 1 3 3 3 0 DNA photolyase EF-hand_1 PF00036.32 KOO21649.1 - 3.8e-07 29.2 0.1 2.1e-05 23.7 0.1 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO21649.1 - 2.8e-06 27.7 2.6 1.8e-05 25.1 0.3 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21649.1 - 3.7e-06 26.4 0.0 0.00017 21.2 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_10 PF14788.6 KOO21649.1 - 1.1e-05 25.2 0.8 0.19 11.6 0.0 2.7 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KOO21649.1 - 1.6e-05 24.1 2.0 0.0013 18.2 0.0 2.8 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 KOO21649.1 - 0.062 13.6 0.9 11 6.3 0.1 3.4 3 1 1 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region 2OG-FeII_Oxy_3 PF13640.6 KOO21650.1 - 1e-08 36.0 0.1 1.6e-08 35.4 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO21650.1 - 0.006 17.0 0.0 0.01 16.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 KOO21650.1 - 0.018 15.4 0.0 0.028 14.8 0.0 1.4 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase DHHC PF01529.20 KOO21652.1 - 2.3e-14 53.6 3.0 6.9e-14 52.1 0.3 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase CSTF_C PF14304.6 KOO21653.1 - 0.051 13.2 0.3 14 5.4 0.0 2.6 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal FAM176 PF14851.6 KOO21653.1 - 0.17 11.6 1.3 0.28 10.8 1.3 1.3 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 KOO21653.1 - 0.59 10.6 8.1 1.1 9.7 8.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 KOO21653.1 - 2.1 7.6 4.8 3.2 7.0 4.8 1.2 1 0 0 1 1 1 0 NOA36 protein Dicty_REP PF05086.12 KOO21653.1 - 6.9 4.5 6.8 9.1 4.1 6.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Acetyltransf_3 PF13302.7 KOO21654.1 - 4.3e-08 33.9 0.0 1.3e-06 29.1 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Hydrolase_4 PF12146.8 KOO21654.1 - 2.5e-05 23.7 1.2 0.0033 16.7 0.5 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO21654.1 - 0.00016 21.4 0.1 0.00033 20.4 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Acetyltransf_1 PF00583.25 KOO21654.1 - 0.059 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Macoilin PF09726.9 KOO21655.1 - 0.0063 15.1 12.6 0.0068 15.0 12.6 1.0 1 0 0 1 1 1 1 Macoilin family WD-3 PF09765.9 KOO21655.1 - 0.01 15.2 1.6 0.014 14.8 1.6 1.3 1 0 0 1 1 1 0 WD-repeat region BST2 PF16716.5 KOO21655.1 - 0.019 15.6 22.4 0.61 10.7 2.5 3.1 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 DrrA_P4M PF14860.6 KOO21655.1 - 0.034 14.0 6.0 0.12 12.3 0.1 2.6 2 1 0 3 3 2 0 DrrA phosphatidylinositol 4-phosphate binding domain zf-His_Me_endon PF05551.11 KOO21655.1 - 0.073 13.3 0.8 0.11 12.7 0.8 1.3 1 0 0 1 1 1 0 Zinc-binding loop region of homing endonuclease TolA_bind_tri PF16331.5 KOO21655.1 - 0.076 13.1 10.9 1.2 9.2 0.1 2.8 2 1 0 2 2 2 0 TolA binding protein trimerisation Fez1 PF06818.15 KOO21655.1 - 0.08 13.4 16.5 0.12 12.8 16.5 1.3 1 0 0 1 1 1 0 Fez1 DUF948 PF06103.11 KOO21655.1 - 0.11 12.7 6.2 6.4 7.1 0.7 3.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF148 PF02520.17 KOO21655.1 - 0.24 11.5 10.9 0.062 13.4 6.9 2.0 1 1 1 2 2 2 0 Domain of unknown function DUF148 Sec34 PF04136.15 KOO21655.1 - 0.28 11.1 7.3 0.15 12.0 4.2 1.9 1 1 0 2 2 2 0 Sec34-like family DUF4201 PF13870.6 KOO21655.1 - 0.31 10.7 20.3 0.11 12.2 5.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) UPF0242 PF06785.11 KOO21655.1 - 0.65 10.1 20.4 0.63 10.1 9.7 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4618 PF15397.6 KOO21655.1 - 0.83 9.0 13.4 0.23 10.8 2.1 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4618) TPR_MLP1_2 PF07926.12 KOO21655.1 - 1.1 9.4 28.6 3.9 7.5 19.6 2.8 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Endonuc-BglII PF09195.11 KOO21655.1 - 1.1 9.1 6.0 0.56 10.0 1.4 2.0 2 0 0 2 2 2 0 Restriction endonuclease BglII DUF1664 PF07889.12 KOO21655.1 - 1.2 9.1 6.8 3.5 7.7 3.2 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 KOO21655.1 - 1.3 9.1 16.6 3.8 7.5 2.3 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cluap1 PF10234.9 KOO21655.1 - 2.2 7.6 18.2 3.7 6.9 8.7 2.0 1 1 1 2 2 2 0 Clusterin-associated protein-1 MCU PF04678.13 KOO21655.1 - 5.6 7.0 11.1 0.68 10.0 1.6 2.1 1 1 1 2 2 2 0 Mitochondrial calcium uniporter APG6_N PF17675.1 KOO21655.1 - 6.1 7.4 21.8 6.6 7.3 18.5 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region JIP_LZII PF16471.5 KOO21655.1 - 6.7 7.0 13.2 2 8.6 0.4 3.7 2 1 2 4 4 4 0 JNK-interacting protein leucine zipper II DUF724 PF05266.14 KOO21655.1 - 9.1 6.1 15.3 9.7 6.0 5.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4446 PF14584.6 KOO21655.1 - 9.1 6.3 7.5 6.6 6.7 1.0 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) TIG PF01833.24 KOO21657.1 - 1.3e-32 111.7 5.3 2.9e-09 36.9 0.6 7.0 6 1 0 6 6 6 6 IPT/TIG domain TIG_plexin PF17960.1 KOO21657.1 - 6.7e-13 48.4 0.0 0.00021 21.2 0.0 5.0 6 0 0 6 6 6 4 TIG domain YrhK PF14145.6 KOO21660.1 - 0.038 13.9 0.1 0.071 13.0 0.1 1.5 1 0 0 1 1 1 0 YrhK-like protein Myosin_head PF00063.21 KOO21662.1 - 1.1e-195 651.8 0.0 1.4e-195 651.5 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) PH PF00169.29 KOO21662.1 - 9.4e-13 48.6 0.3 1.1e-08 35.5 0.2 2.7 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 KOO21662.1 - 9.8e-05 22.7 0.3 0.00076 19.9 0.1 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain AAA_16 PF13191.6 KOO21662.1 - 0.00042 20.7 0.0 0.035 14.5 0.0 3.0 2 0 0 2 2 2 1 AAA ATPase domain PH_15 PF17339.2 KOO21662.1 - 0.041 13.8 0.2 0.45 10.4 0.0 2.5 2 0 0 2 2 2 0 PH domain FERM_N PF09379.10 KOO21662.1 - 0.042 13.8 0.0 0.15 12.1 0.0 1.9 1 0 0 1 1 1 0 FERM N-terminal domain PH_8 PF15409.6 KOO21662.1 - 0.056 13.7 0.3 0.61 10.4 0.1 2.7 2 1 1 3 3 3 0 Pleckstrin homology domain T2SSE PF00437.20 KOO21662.1 - 0.14 11.2 0.0 0.28 10.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein IQ PF00612.27 KOO21662.1 - 0.56 10.2 13.4 0.45 10.5 1.3 4.0 3 0 0 3 3 3 0 IQ calmodulin-binding motif YEATS PF03366.16 KOO21663.1 - 1.4e-27 95.4 0.0 2.1e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 YEATS family SCNM1_acidic PF15805.5 KOO21663.1 - 0.13 12.0 1.5 0.25 11.1 0.2 2.2 2 0 0 2 2 2 0 Acidic C-terminal region of sodium channel modifier 1 SCNM1 RINGv PF12906.7 KOO21664.1 - 1.7e-11 44.0 4.8 3.8e-11 42.9 4.8 1.6 1 0 0 1 1 1 1 RING-variant domain DUF179 PF02622.15 KOO21664.1 - 1.6e-05 24.9 0.2 0.00011 22.3 0.2 2.1 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 K_channel_TID PF07941.11 KOO21664.1 - 2.5 8.6 9.5 5.7 7.5 9.5 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain TENA_THI-4 PF03070.16 KOO21665.1 - 2.7e-11 43.7 0.0 2.9e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Haem_oxygenas_2 PF14518.6 KOO21665.1 - 0.0086 15.9 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Iron-containing redox enzyme TIR_2 PF13676.6 KOO21666.1 - 2.2e-18 67.0 0.0 1.5e-08 35.2 0.0 3.5 3 0 0 3 3 3 2 TIR domain Neurochondrin PF05536.11 KOO21666.1 - 0.0031 15.9 3.1 5.6 5.2 0.1 3.7 4 0 0 4 4 4 3 Neurochondrin TIR PF01582.20 KOO21666.1 - 0.027 14.3 0.1 7.6 6.3 0.1 3.1 3 0 0 3 3 3 0 TIR domain Proteasom_PSMB PF10508.9 KOO21666.1 - 0.076 11.5 0.0 0.076 11.5 0.0 2.9 4 1 1 5 5 5 0 Proteasome non-ATPase 26S subunit DUF3636 PF12331.8 KOO21666.1 - 0.078 12.8 0.0 0.28 11.0 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) TMF_DNA_bd PF12329.8 KOO21666.1 - 0.11 12.5 1.4 0.28 11.2 1.4 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Arm PF00514.23 KOO21666.1 - 0.35 11.0 16.5 3.6 7.8 0.0 7.6 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat FliJ PF02050.16 KOO21666.1 - 2.1 8.6 10.6 0.33 11.2 5.6 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein Pkinase PF00069.25 KOO21667.1 - 1e-47 162.8 0.0 1.4e-47 162.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21667.1 - 2.7e-42 144.8 0.0 4.8e-42 144.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO21667.1 - 3.1e-06 26.2 0.0 4.7e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO21667.1 - 0.0066 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO21667.1 - 0.031 14.2 0.1 0.098 12.6 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family ADK PF00406.22 KOO21668.1 - 3.8e-05 23.8 0.0 0.0099 16.0 0.0 3.1 3 0 0 3 3 3 1 Adenylate kinase CH_2 PF06294.11 KOO21668.1 - 0.00012 22.1 0.0 0.00042 20.4 0.0 2.0 2 0 0 2 2 2 1 CH-like domain in sperm protein CH PF00307.31 KOO21668.1 - 0.032 14.4 0.0 0.063 13.5 0.0 1.5 1 0 0 1 1 1 0 Calponin homology (CH) domain ADK_lid PF05191.14 KOO21668.1 - 0.11 12.5 0.1 0.37 10.8 0.0 2.0 2 0 0 2 2 2 0 Adenylate kinase, active site lid F420_oxidored PF03807.17 KOO21668.1 - 5.6 7.6 7.8 2.1 9.0 0.0 3.4 3 1 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent Abhydrolase_6 PF12697.7 KOO21670.1 - 6.9e-09 36.6 10.1 8.9e-09 36.3 10.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO21670.1 - 1.8e-07 31.1 0.0 1.5e-06 28.1 0.1 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO21670.1 - 0.00011 21.6 0.1 0.00044 19.6 0.1 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ndr PF03096.14 KOO21670.1 - 0.0039 15.9 0.1 0.0054 15.5 0.1 1.2 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.13 KOO21670.1 - 0.0039 17.1 0.1 0.15 11.9 0.1 2.1 2 0 0 2 2 2 1 Serine hydrolase Esterase PF00756.20 KOO21670.1 - 0.015 15.0 0.1 0.017 14.8 0.1 1.5 1 1 0 1 1 1 0 Putative esterase PGAP1 PF07819.13 KOO21670.1 - 0.032 14.0 0.0 0.041 13.6 0.0 1.1 1 0 0 1 1 1 0 PGAP1-like protein Chlorophyllase2 PF12740.7 KOO21670.1 - 0.054 12.4 0.0 0.073 12.0 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Lipase_3 PF01764.25 KOO21670.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_5 PF12695.7 KOO21670.1 - 0.2 11.4 0.0 0.3 10.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Vps52 PF04129.12 KOO21671.1 - 2.3e-112 376.4 0.0 2.8e-112 376.1 0.0 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 KOO21671.1 - 1.9e-08 33.2 5.9 4.1e-07 28.8 5.2 2.8 3 1 0 3 3 3 1 Exocyst complex component Sec3 COG2 PF06148.11 KOO21671.1 - 0.0036 17.4 0.9 0.0036 17.4 0.9 2.2 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 KOO21671.1 - 0.099 12.7 2.1 5.7 7.0 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) RAG2_PHD PF13341.6 KOO21671.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 RAG2 PHD domain Complex1_LYR PF05347.15 KOO21672.1 - 5.2e-08 32.8 0.1 7e-08 32.4 0.1 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOO21672.1 - 0.0023 18.6 0.0 0.0029 18.3 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like C2 PF00168.30 KOO21673.1 - 1.9e-17 63.4 0.0 3.4e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 C2 domain CH PF00307.31 KOO21673.1 - 3.6e-11 43.2 0.0 6.1e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 KOO21673.1 - 0.0019 18.4 0.0 0.0046 17.2 0.0 1.6 1 0 0 1 1 1 1 CDC24 Calponin Aldo_ket_red PF00248.21 KOO21674.1 - 9.3e-58 195.7 0.0 3.2e-57 194.0 0.0 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family zf-C2H2_4 PF13894.6 KOO21675.1 - 0.0019 18.9 0.3 0.0031 18.2 0.3 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KOO21675.1 - 0.0025 18.1 0.0 0.0034 17.7 0.0 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 KOO21675.1 - 0.056 13.9 0.7 0.095 13.2 0.7 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type Endonuclease_7 PF02945.15 KOO21675.1 - 0.078 12.9 0.1 0.1 12.5 0.1 1.2 1 0 0 1 1 1 0 Recombination endonuclease VII Zf_RING PF16744.5 KOO21675.1 - 0.14 12.3 0.1 0.19 11.8 0.1 1.2 1 0 0 1 1 1 0 KIAA1045 RING finger GTP_EFTU PF00009.27 KOO21676.1 - 1.2e-62 210.9 0.0 1.9e-62 210.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KOO21676.1 - 1.1e-39 134.9 0.3 2e-39 134.1 0.3 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 KOO21676.1 - 2e-32 111.1 0.0 4e-32 110.1 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KOO21676.1 - 3.1e-27 94.4 0.2 9e-27 92.9 0.2 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOO21676.1 - 7.4e-15 55.1 2.2 1.2e-14 54.4 0.9 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 KOO21676.1 - 1.1e-05 25.2 0.0 2e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain LRR_6 PF13516.6 KOO21677.1 - 0.0071 16.3 0.0 0.062 13.4 0.1 2.3 2 0 0 2 2 2 1 Leucine Rich repeat Methyltransf_11 PF08241.12 KOO21678.1 - 1.2e-12 48.3 0.0 2.1e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO21678.1 - 1.5e-12 48.0 0.0 2.8e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO21678.1 - 2.7e-06 28.0 0.0 4.9e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO21678.1 - 2e-05 24.5 0.0 2.9e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO21678.1 - 3e-05 23.9 0.0 3.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO21678.1 - 0.0026 17.1 0.0 0.0031 16.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 KOO21678.1 - 0.024 14.0 0.0 0.076 12.3 0.0 1.7 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 KOO21678.1 - 0.066 13.2 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOO21678.1 - 0.069 12.7 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 KOO21678.1 - 0.083 12.6 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) EF-hand_1 PF00036.32 KOO21679.1 - 1.2e-15 55.8 3.5 2.2e-08 33.1 0.3 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO21679.1 - 3.7e-15 55.5 1.4 1e-12 47.7 0.4 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO21679.1 - 2.9e-14 53.3 0.4 2.5e-13 50.2 0.9 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO21679.1 - 2.9e-14 51.7 0.6 2.5e-06 27.0 0.0 4.1 4 2 1 5 5 5 2 EF-hand domain EF-hand_5 PF13202.6 KOO21679.1 - 1.4e-09 37.0 0.4 0.00051 19.4 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO21679.1 - 7.1e-05 23.1 0.0 0.00015 22.0 0.0 1.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 KOO21679.1 - 0.0056 16.6 0.1 0.011 15.7 0.1 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand UBA_6 PF18039.1 KOO21679.1 - 0.074 13.0 0.0 0.69 9.9 0.0 2.1 2 0 0 2 2 2 0 UBA-like domain SPARC_Ca_bdg PF10591.9 KOO21679.1 - 0.078 13.3 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 KOO21679.1 - 0.09 12.8 0.0 2.7 8.1 0.0 2.7 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0154) TPT PF03151.16 KOO21680.1 - 5.6e-10 39.0 16.4 6.8e-10 38.8 16.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 KOO21680.1 - 0.0011 18.2 16.3 0.0022 17.2 16.3 1.5 1 1 0 1 1 1 1 UAA transporter family Chordopox_L2 PF05803.12 KOO21680.1 - 0.064 13.1 0.0 0.064 13.1 0.0 3.5 4 1 0 4 4 4 0 Chordopoxvirus L2 protein 2OG-FeII_Oxy_3 PF13640.6 KOO21682.1 - 1.2e-06 29.3 0.0 2.3e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Endonuclease_5 PF04493.14 KOO21682.1 - 0.014 15.1 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 Endonuclease V Asp_Arg_Hydrox PF05118.15 KOO21682.1 - 0.18 11.6 1.9 11 5.9 0.0 2.6 3 0 0 3 3 3 0 Aspartyl/Asparaginyl beta-hydroxylase HMG_CoA_synt_N PF01154.17 KOO21683.1 - 1.2e-73 246.7 0.0 1.8e-73 246.1 0.0 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 KOO21683.1 - 6.9e-65 219.4 0.0 1.2e-64 218.6 0.0 1.3 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal GHMP_kinases_C PF08544.13 KOO21684.1 - 0.076 13.4 0.5 0.11 12.8 0.5 1.4 1 1 0 1 1 1 0 GHMP kinases C terminal DUF2203 PF09969.9 KOO21687.1 - 2.2 9.0 6.5 6.6 7.5 0.0 2.8 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Auto_anti-p27 PF06677.12 KOO21689.1 - 1.5e-07 31.4 0.7 2.6e-07 30.7 0.7 1.4 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) PRIMA1 PF16101.5 KOO21689.1 - 2.6 8.1 7.1 2.2 8.3 4.0 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Filamin PF00630.19 KOO21690.1 - 7.1e-58 193.8 2.4 1e-16 61.6 0.1 7.3 6 1 1 7 7 7 7 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO21690.1 - 7.9e-16 58.1 0.8 0.00071 19.8 0.0 5.0 4 1 1 5 5 5 3 Invasin, domain 3 CarboxypepD_reg PF13620.6 KOO21690.1 - 0.0011 19.2 7.9 1.6 9.1 0.5 4.6 5 0 0 5 5 5 2 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 KOO21690.1 - 0.0091 16.0 1.1 6.1 6.9 0.0 4.7 5 0 0 5 5 5 1 Bacterial Ig-like domain (group 1) DUF3244 PF11589.8 KOO21690.1 - 0.047 13.8 0.6 2 8.5 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3244) DUF5060 PF16586.5 KOO21690.1 - 0.084 13.3 0.6 82 3.7 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) SH3_3 PF08239.11 KOO21690.1 - 0.16 12.3 0.4 0.52 10.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial SH3 domain PapC_N PF13954.6 KOO21690.1 - 0.17 11.9 0.0 2.2 8.3 0.0 2.4 2 0 0 2 2 2 0 PapC N-terminal domain YtkA PF13115.6 KOO21690.1 - 0.34 11.5 6.3 19 6.0 0.0 5.3 6 0 0 6 6 6 0 YtkA-like Y_Y_Y PF07495.13 KOO21690.1 - 1.4 9.0 7.2 13 5.8 0.1 4.4 5 0 0 5 5 5 0 Y_Y_Y domain EF-hand_1 PF00036.32 KOO21691.1 - 1.8e-12 45.8 0.6 2.7e-05 23.4 0.1 2.7 2 0 0 2 2 2 2 EF hand ART PF01129.18 KOO21691.1 - 1.6e-10 40.7 2.1 2.3e-08 33.6 0.0 2.4 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase EF-hand_7 PF13499.6 KOO21691.1 - 2.6e-09 37.4 1.2 1e-08 35.5 1.2 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO21691.1 - 1.2e-07 31.1 0.1 0.024 14.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO21691.1 - 2.2e-07 30.6 0.6 0.019 14.8 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO21691.1 - 2.2e-06 26.9 1.4 0.0015 17.9 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 KOO21691.1 - 0.0023 17.8 0.3 0.006 16.4 0.3 1.8 1 0 0 1 1 1 1 EF hand ADPrib_exo_Tox PF03496.14 KOO21691.1 - 0.0053 16.1 0.0 0.012 14.9 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme EF-hand_4 PF12763.7 KOO21691.1 - 0.013 15.4 1.6 1.5 8.8 0.1 2.7 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Ndc1_Nup PF09531.10 KOO21691.1 - 0.036 12.8 2.4 0.14 10.8 2.0 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup SPARC_Ca_bdg PF10591.9 KOO21691.1 - 0.076 13.3 0.3 0.076 13.3 0.3 2.4 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region IQ PF00612.27 KOO21691.1 - 0.22 11.4 1.2 0.52 10.2 1.2 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Pkinase PF00069.25 KOO21692.1 - 4.1e-56 190.3 0.0 5.2e-56 189.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21692.1 - 3.8e-33 114.9 0.0 3.1e-32 111.9 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO21692.1 - 1.1e-07 31.5 0.1 2.6e-07 30.2 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO21692.1 - 1.4e-06 28.4 0.4 1.3e-05 25.2 0.1 1.9 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOO21692.1 - 0.0046 16.6 0.0 0.022 14.4 0.0 1.9 1 1 0 1 1 1 1 Choline/ethanolamine kinase FTA2 PF13095.6 KOO21692.1 - 0.0056 16.3 0.0 0.011 15.4 0.0 1.6 1 1 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 KOO21692.1 - 0.0061 15.9 0.0 0.073 12.4 0.0 2.0 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 KOO21692.1 - 0.0076 15.9 0.0 0.017 14.7 0.0 1.5 1 1 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 KOO21692.1 - 0.0082 15.1 0.0 0.0096 14.9 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KOO21692.1 - 0.0086 14.9 0.0 0.014 14.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 KOO21692.1 - 0.056 12.5 0.0 0.084 11.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 SAP PF02037.27 KOO21693.1 - 2.7e-07 30.2 0.2 8.3e-07 28.6 0.2 1.9 1 0 0 1 1 1 1 SAP domain DUF4891 PF16232.5 KOO21693.1 - 0.11 13.0 0.0 17 6.0 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4891) CBFB_NFYA PF02045.15 KOO21694.1 - 1.5e-15 57.5 1.2 2.1e-15 57.1 1.2 1.1 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Pkinase PF00069.25 KOO21695.1 - 1.6e-42 145.7 0.0 2.2e-42 145.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21695.1 - 2.5e-18 66.3 0.0 4e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO21695.1 - 0.00077 19.5 0.0 0.0019 18.1 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KOO21695.1 - 0.013 14.8 0.7 0.023 14.1 0.7 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOO21695.1 - 0.059 13.0 0.2 0.1 12.2 0.2 1.3 1 0 0 1 1 1 0 RIO1 family ABC_tran PF00005.27 KOO21696.1 - 9.1e-32 110.4 0.0 3.8e-19 69.6 0.0 3.2 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 KOO21696.1 - 1.9e-15 57.5 0.5 0.0016 18.3 0.1 3.3 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO21696.1 - 6.4e-11 42.1 0.0 0.007 15.8 0.0 3.9 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOO21696.1 - 3e-08 33.3 0.2 0.0015 18.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_tran_CTD PF16326.5 KOO21696.1 - 4.1e-08 33.3 23.3 4.1e-07 30.2 5.8 4.2 4 0 0 4 4 3 2 ABC transporter C-terminal domain AAA_23 PF13476.6 KOO21696.1 - 5.2e-08 33.6 9.0 0.012 16.1 0.0 4.2 4 1 0 4 4 3 2 AAA domain AAA_18 PF13238.6 KOO21696.1 - 2.6e-07 31.3 0.1 0.056 14.0 0.0 3.4 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 KOO21696.1 - 8.6e-07 29.0 2.4 0.0014 18.6 0.0 2.7 3 0 0 3 3 2 2 RsgA GTPase AAA_33 PF13671.6 KOO21696.1 - 1.7e-06 28.2 3.6 0.0004 20.6 0.0 3.6 4 0 0 4 4 3 1 AAA domain NACHT PF05729.12 KOO21696.1 - 5.2e-06 26.5 0.2 0.2 11.6 0.1 2.9 3 0 0 3 3 2 2 NACHT domain Rad17 PF03215.15 KOO21696.1 - 2.3e-05 24.4 0.4 0.22 11.4 0.0 2.6 2 1 0 2 2 2 2 Rad17 P-loop domain RNA_helicase PF00910.22 KOO21696.1 - 3.3e-05 24.2 0.0 0.37 11.2 0.0 3.3 3 0 0 3 3 3 2 RNA helicase AAA_22 PF13401.6 KOO21696.1 - 0.00014 22.2 0.4 0.4 10.9 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_27 PF13514.6 KOO21696.1 - 0.00019 21.1 5.9 0.2 11.3 0.0 3.9 3 1 1 4 4 4 2 AAA domain AAA PF00004.29 KOO21696.1 - 0.00032 21.1 0.0 1.1 9.7 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO21696.1 - 0.00082 19.8 11.5 0.18 12.2 0.0 3.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 KOO21696.1 - 0.0012 18.6 0.1 2.3 7.8 0.0 2.6 3 0 0 3 3 2 2 AAA ATPase domain AAA_24 PF13479.6 KOO21696.1 - 0.0012 18.6 0.0 0.82 9.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 KOO21696.1 - 0.0014 18.3 4.2 0.42 10.2 0.1 4.0 4 0 0 4 4 4 1 AAA domain AAA_30 PF13604.6 KOO21696.1 - 0.0022 17.8 2.6 0.32 10.7 0.0 3.5 3 1 0 3 3 2 1 AAA domain T2SSE PF00437.20 KOO21696.1 - 0.0027 16.8 0.2 0.035 13.2 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 KOO21696.1 - 0.0028 17.4 0.3 1.4 8.6 0.0 3.4 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_14 PF13173.6 KOO21696.1 - 0.0036 17.3 0.0 5.3 7.1 0.0 3.0 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 KOO21696.1 - 0.0048 16.1 0.1 2 7.5 0.0 2.5 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 MMR_HSR1 PF01926.23 KOO21696.1 - 0.012 15.7 3.6 0.75 9.9 0.0 3.0 3 0 0 3 3 2 0 50S ribosome-binding GTPase DUF815 PF05673.13 KOO21696.1 - 0.016 14.4 0.2 1.4 8.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 KOO21696.1 - 0.018 14.8 0.1 3.2 7.5 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 KOO21696.1 - 0.022 14.1 3.3 0.19 11.1 0.1 2.8 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 KOO21696.1 - 0.026 14.4 0.8 6.1 6.7 0.1 2.9 3 0 0 3 3 2 0 NTPase TsaE PF02367.17 KOO21696.1 - 0.028 14.4 0.4 0.63 10.1 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 KOO21696.1 - 0.052 13.6 6.9 1.4 8.9 0.2 3.3 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 KOO21696.1 - 0.058 12.5 0.0 4.9 6.2 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit Dynamin_N PF00350.23 KOO21696.1 - 0.071 13.2 1.6 9.5 6.2 0.0 3.3 4 0 0 4 4 2 0 Dynamin family AAA_28 PF13521.6 KOO21696.1 - 0.076 13.3 12.7 0.2 11.9 0.0 3.9 5 1 1 6 6 2 0 AAA domain dNK PF01712.19 KOO21696.1 - 0.079 12.8 0.4 5.1 6.9 0.0 2.6 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_7 PF12775.7 KOO21696.1 - 0.08 12.4 0.1 3.7 7.0 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase_2 PF01637.18 KOO21696.1 - 0.098 12.6 1.3 3.1 7.7 0.0 2.8 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea MutS_V PF00488.21 KOO21696.1 - 0.1 12.6 0.5 6.7 6.7 0.0 2.4 2 0 0 2 2 2 0 MutS domain V Viral_helicase1 PF01443.18 KOO21696.1 - 0.15 11.7 0.1 9.8 5.8 0.1 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Fibrillin_U_N PF18193.1 KOO21696.1 - 0.17 12.0 1.6 0.67 10.1 0.2 2.3 2 0 0 2 2 2 0 Fibrillin 1 unique N-terminal domain cobW PF02492.19 KOO21696.1 - 0.19 11.3 5.4 2.8 7.5 0.0 3.7 3 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Adeno_IVa2 PF02456.15 KOO21696.1 - 0.46 9.2 1.3 19 3.9 0.1 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein FUSC PF04632.12 KOO21696.1 - 9.3 4.7 19.8 11 4.4 15.6 2.4 2 0 0 2 2 2 0 Fusaric acid resistance protein family EF-hand_5 PF13202.6 KOO21697.1 - 0.008 15.6 0.1 0.017 14.6 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO21697.1 - 0.02 14.4 0.1 0.041 13.4 0.1 1.5 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 KOO21697.1 - 0.042 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain LRR_6 PF13516.6 KOO21698.1 - 3.5e-06 26.6 0.0 4.6e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Leucine Rich repeat PAN_1 PF00024.26 KOO21699.1 - 7.5e-14 51.5 0.1 4.4e-07 29.8 0.1 2.3 2 0 0 2 2 2 2 PAN domain PAN_4 PF14295.6 KOO21699.1 - 3.3e-12 46.1 6.4 2e-07 30.8 0.4 2.8 2 1 0 2 2 2 2 PAN domain PAN_2 PF08276.11 KOO21699.1 - 0.0028 17.7 2.5 0.12 12.5 0.2 2.4 2 0 0 2 2 2 2 PAN-like domain ELMO_CED12 PF04727.13 KOO21700.1 - 1e-24 87.6 0.0 1.6e-24 87.0 0.0 1.4 1 1 0 1 1 1 1 ELMO/CED-12 family MAAL_N PF05034.13 KOO21700.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase N-terminus EF-hand_1 PF00036.32 KOO21701.1 - 1.6e-16 58.6 0.0 0.0021 17.5 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO21701.1 - 4.7e-14 51.0 0.0 0.043 13.7 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO21701.1 - 2.1e-11 44.1 1.3 0.00032 21.1 0.0 3.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO21701.1 - 9e-10 37.6 2.7 0.28 10.8 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO21701.1 - 0.022 14.6 0.4 8 6.4 0.1 3.7 3 1 1 4 4 4 0 EF-hand domain pair 2Fe-2S_thioredx PF01257.19 KOO21702.1 - 0.00022 21.1 0.6 0.00022 21.1 0.6 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin XPG_N PF00752.17 KOO21703.1 - 5.3e-30 103.9 0.0 9.8e-30 103.0 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KOO21703.1 - 7.2e-27 93.6 0.4 1.4e-26 92.6 0.0 1.7 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 KOO21703.1 - 7.3e-07 29.7 0.0 3.2e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 KOO21703.1 - 0.00071 20.1 0.0 0.0033 18.0 0.0 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain 5_3_exonuc_N PF02739.16 KOO21703.1 - 0.019 14.9 0.0 0.086 12.7 0.0 1.8 1 1 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain DUF4554 PF15091.6 KOO21703.1 - 0.21 10.4 0.5 0.31 9.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) DnaJ PF00226.31 KOO21704.1 - 2.9e-26 91.4 5.1 4.3e-26 90.8 5.1 1.3 1 0 0 1 1 1 1 DnaJ domain Forkhead_N PF08430.12 KOO21704.1 - 0.086 13.4 13.7 0.2 12.3 13.7 1.7 1 0 0 1 1 1 0 Forkhead N-terminal region NAPRTase PF04095.16 KOO21705.1 - 1.7e-58 198.1 0.0 2.1e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF5598 PF18127.1 KOO21705.1 - 4.4e-39 132.9 0.1 1.3e-38 131.3 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5598) zf-Tim10_DDP PF02953.15 KOO21706.1 - 1.2e-23 82.5 1.7 1.5e-23 82.2 1.7 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Pkinase PF00069.25 KOO21707.1 - 5.8e-53 179.9 0.0 1.1e-52 179.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21707.1 - 3.4e-27 95.4 0.0 5.9e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 KOO21707.1 - 3.9e-26 90.9 0.1 6.7e-14 51.7 0.0 2.9 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RGS PF00615.19 KOO21707.1 - 8.5e-12 45.4 0.0 3.2e-11 43.5 0.0 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain GRAM PF02893.20 KOO21707.1 - 0.00011 22.0 0.0 0.00021 21.1 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Kinase-like PF14531.6 KOO21707.1 - 0.0011 18.4 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO21707.1 - 0.0091 14.8 0.0 0.016 14.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO21707.1 - 0.032 13.6 0.2 0.059 12.7 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PIP49_C PF12260.8 KOO21707.1 - 0.058 13.0 1.2 8.2 6.0 0.0 3.1 2 1 0 3 3 3 0 Protein-kinase domain of FAM69 DUF179 PF02622.15 KOO21708.1 - 6.8e-12 45.6 0.1 2.8e-11 43.7 0.0 2.1 2 1 0 2 2 2 1 Uncharacterized ACR, COG1678 Cyt-b5 PF00173.28 KOO21709.1 - 4.9e-07 29.8 0.0 7.4e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SecA_DEAD PF07517.14 KOO21711.1 - 4.2e-08 32.8 0.0 1.5e-07 31.0 0.0 1.9 1 0 0 1 1 1 1 SecA DEAD-like domain DnaJ PF00226.31 KOO21711.1 - 2e-07 31.0 0.1 5.3e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain MMR_HSR1 PF01926.23 KOO21711.1 - 0.0029 17.7 0.0 0.011 15.9 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO21711.1 - 0.026 14.4 0.0 0.077 12.9 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 KOO21711.1 - 0.041 14.4 0.0 0.34 11.4 0.0 2.7 2 0 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 KOO21711.1 - 0.056 13.0 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 KOO21711.1 - 0.08 12.7 0.3 2.6 7.9 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain EF-hand_1 PF00036.32 KOO21712.1 - 6.5e-13 47.2 2.6 1.4e-05 24.3 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO21712.1 - 1.3e-11 43.4 0.1 9e-06 25.2 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO21712.1 - 1.6e-11 44.5 0.2 2.1e-11 44.1 0.2 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO21712.1 - 1.4e-09 37.0 0.7 0.00015 21.1 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21712.1 - 1.5e-08 34.3 1.4 2.6e-05 24.0 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair DUF3126 PF11324.8 KOO21712.1 - 0.02 14.7 0.0 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3126) SPARC_Ca_bdg PF10591.9 KOO21712.1 - 0.027 14.8 0.1 0.039 14.3 0.1 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region SHOCT PF09851.9 KOO21712.1 - 0.16 11.7 0.3 1 9.2 0.0 2.3 2 0 0 2 2 2 0 Short C-terminal domain FA_hydroxylase PF04116.13 KOO21713.1 - 0.0044 17.4 7.8 0.0071 16.7 0.5 2.8 3 0 0 3 3 3 2 Fatty acid hydroxylase superfamily Brix PF04427.18 KOO21714.1 - 4.6e-14 53.0 0.0 5.5e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Brix domain AMP-binding PF00501.28 KOO21715.1 - 1.3e-96 323.8 0.0 1.7e-96 323.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Myelin_MBP PF01669.17 KOO21715.1 - 0.12 13.0 3.0 1 10.0 1.2 3.0 3 0 0 3 3 3 0 Myelin basic protein PAP_central PF04928.17 KOO21716.1 - 2.6e-74 249.4 0.0 3.4e-74 249.0 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain His_Phos_1 PF00300.22 KOO21716.1 - 1.2e-07 31.6 2.4 1.3e-05 25.0 0.2 3.4 3 1 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) NTP_transf_2 PF01909.23 KOO21716.1 - 4.6e-06 26.8 0.0 1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_RNA-bind PF04926.15 KOO21716.1 - 0.00023 20.8 0.0 0.0013 18.4 0.0 2.0 1 1 0 2 2 2 1 Poly(A) polymerase predicted RNA binding domain Semialdhyde_dh PF01118.24 KOO21717.1 - 4e-10 40.2 0.5 5.9e-08 33.2 0.2 3.1 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KOO21717.1 - 0.011 16.3 1.1 0.018 15.6 0.1 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 KOO21717.1 - 0.044 14.0 0.3 0.11 12.7 0.3 1.7 1 0 0 1 1 1 0 TrkA-N domain PFK PF00365.20 KOO21718.1 - 8.1e-37 127.1 0.2 2e-36 125.8 0.2 1.6 1 1 0 1 1 1 1 Phosphofructokinase FA_hydroxylase PF04116.13 KOO21719.1 - 3.5e-17 63.0 14.3 4.4e-17 62.7 14.3 1.1 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily MFS_1 PF07690.16 KOO21720.1 - 1.3e-39 136.2 11.7 1.7e-25 89.8 1.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOO21720.1 - 3.7e-05 22.8 6.3 0.16 10.8 0.0 3.1 2 1 1 3 3 3 2 MFS_1 like family Multi_Drug_Res PF00893.19 KOO21720.1 - 0.017 15.8 0.8 0.017 15.8 0.8 3.5 3 1 1 4 4 4 0 Small Multidrug Resistance protein MFS_3 PF05977.13 KOO21720.1 - 0.13 10.7 19.1 0.039 12.3 0.4 3.3 2 2 1 4 4 4 0 Transmembrane secretion effector Aldo_ket_red PF00248.21 KOO21721.1 - 4.7e-38 131.0 0.0 5.2e-36 124.4 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family 2OG-FeII_Oxy_3 PF13640.6 KOO21722.1 - 1.1e-11 45.5 0.0 1.7e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_6 PF13405.6 KOO21723.1 - 7e-13 47.4 0.0 2.4e-05 23.9 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO21723.1 - 1.9e-12 45.8 0.2 1.5e-05 24.2 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO21723.1 - 6.4e-10 39.3 0.4 2.4e-07 31.1 0.1 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO21723.1 - 7.9e-08 31.5 0.9 6.7e-05 22.2 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21723.1 - 4e-06 26.6 0.3 5.8e-05 22.9 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair RuBisCO_small PF00101.20 KOO21723.1 - 0.15 12.0 17.3 5.4 7.1 0.0 7.5 9 0 0 9 9 9 0 Ribulose bisphosphate carboxylase, small chain Sec23_BS PF08033.12 KOO21724.1 - 5e-13 49.6 0.0 1.2e-12 48.4 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 KOO21724.1 - 1.4e-05 24.8 0.4 3.1e-05 23.7 0.4 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain DUF3281 PF11685.8 KOO21724.1 - 1.4e-05 24.6 68.8 0.055 12.8 0.9 9.9 1 1 9 10 10 10 7 Protein of unknown function (DUF3281) DUF3935 PF13071.6 KOO21724.1 - 1.8e-05 25.2 0.0 26 5.4 0.0 7.1 10 0 0 10 10 10 0 Protein of unknown function (DUF3935) DUF4160 PF13711.6 KOO21724.1 - 2.2e-05 24.7 0.0 7.7 6.9 0.0 6.4 7 0 0 7 7 7 1 Domain of unknown function (DUF4160) T2SSI PF02501.17 KOO21724.1 - 0.00016 21.8 1.9 1.4e+02 2.7 0.0 6.9 5 1 0 7 7 7 0 Type II secretion system (T2SS), protein I BAMBI PF06211.12 KOO21724.1 - 0.018 15.3 0.0 0.071 13.4 0.0 2.1 1 0 0 1 1 1 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain Sec23_trunk PF04811.15 KOO21724.1 - 0.081 12.5 0.0 0.27 10.7 0.0 1.9 1 1 0 1 1 1 0 Sec23/Sec24 trunk domain DUF4861 PF16153.5 KOO21724.1 - 0.12 11.3 6.3 59 2.5 0.0 4.9 3 2 2 5 5 5 0 Domain of unknown function (DUF4861) TUDOR_5 PF18359.1 KOO21724.1 - 1.1 9.0 4.4 2.2e+02 1.6 0.0 5.1 6 0 0 6 6 6 0 Histone methyltransferase Tudor domain 1 Tubulin PF00091.25 KOO21725.1 - 9e-57 192.5 0.0 1.3e-56 192.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOO21725.1 - 4.1e-44 149.8 0.0 1.2e-43 148.3 0.0 1.8 1 1 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 KOO21725.1 - 0.0028 16.9 0.0 0.0046 16.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Hrs_helical PF12210.8 KOO21725.1 - 0.077 13.5 0.1 0.18 12.4 0.1 1.6 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Ank_2 PF12796.7 KOO21726.1 - 1.5e-13 51.1 0.0 3.7e-07 30.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO21726.1 - 2.2e-11 43.6 0.9 0.00056 20.2 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOO21726.1 - 2.5e-09 37.2 0.1 7.2e-07 29.4 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO21726.1 - 4.4e-08 32.8 0.2 6.4e-06 26.1 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 KOO21726.1 - 1e-06 29.1 0.0 4.6e-05 23.9 0.0 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) EF-hand_5 PF13202.6 KOO21726.1 - 5.6e-05 22.5 0.7 0.00058 19.2 0.4 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO21726.1 - 6.8e-05 23.2 3.6 0.0064 16.9 0.3 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21726.1 - 0.00012 21.7 0.3 0.0076 16.1 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO21726.1 - 0.0012 18.2 0.9 0.0038 16.7 0.1 2.2 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 KOO21726.1 - 0.017 15.0 0.1 0.055 13.3 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair E2F_TDP PF02319.20 KOO21727.1 - 1e-35 121.6 0.0 1.8e-17 63.1 0.0 2.4 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 KOO21727.1 - 0.0055 16.6 0.1 0.022 14.6 0.0 2.0 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB LRR_6 PF13516.6 KOO21729.1 - 5.3e-18 63.5 32.6 0.46 10.7 0.0 16.5 17 0 0 17 17 17 4 Leucine Rich repeat LRR_1 PF00560.33 KOO21729.1 - 3.2e-09 36.1 1.7 18 6.4 0.1 10.0 12 0 0 12 12 12 1 Leucine Rich Repeat LRR_4 PF12799.7 KOO21729.1 - 9.3e-06 25.9 17.8 5.1 7.7 0.0 8.0 7 2 0 7 7 7 3 Leucine Rich repeats (2 copies) Skp1 PF01466.19 KOO21729.1 - 0.00089 19.3 0.0 0.013 15.6 0.0 2.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain LRR_8 PF13855.6 KOO21729.1 - 0.00099 18.8 16.1 4.6 7.1 0.7 8.4 8 3 0 8 8 8 1 Leucine rich repeat HOASN PF14515.6 KOO21729.1 - 0.0021 18.4 4.2 8.1 6.9 0.0 6.2 5 2 2 7 7 7 1 Haem-oxygenase-associated N-terminal helices DUF2202 PF09968.9 KOO21729.1 - 0.015 15.1 0.4 27 4.6 0.0 4.1 4 0 0 4 4 4 0 Uncharacterized protein domain (DUF2202) Metal_CEHH PF14455.6 KOO21729.1 - 0.083 12.5 0.1 20 4.7 0.0 3.2 2 1 1 3 3 3 0 Predicted metal binding domain ERM PF00769.19 KOO21730.1 - 0.00013 21.8 22.7 0.00013 21.8 22.7 2.0 2 0 0 2 2 2 1 Ezrin/radixin/moesin family DUF3584 PF12128.8 KOO21730.1 - 2.4 5.6 23.3 3.7 5.0 23.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Sortilin-Vps10 PF15902.5 KOO21731.1 - 1e-113 380.5 2.4 1.5e-113 380.0 2.4 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KOO21731.1 - 3.9e-41 141.2 1.9 6e-41 140.6 1.9 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KOO21731.1 - 2.9e-07 29.5 2.8 1.2 9.4 0.0 5.5 4 0 0 4 4 4 3 BNR/Asp-box repeat BNR_2 PF13088.6 KOO21731.1 - 9.2e-05 21.9 5.4 0.11 11.8 0.1 4.2 2 2 0 2 2 2 2 BNR repeat-like domain DUF523 PF04463.12 KOO21731.1 - 0.14 12.2 1.2 0.27 11.3 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF523) Galactosyl_T PF01762.21 KOO21732.1 - 3.6e-05 23.7 0.0 9.4e-05 22.3 0.0 1.7 1 1 0 1 1 1 1 Galactosyltransferase Ofd1_CTDD PF10637.9 KOO21733.1 - 4.8e-44 150.6 0.0 6.4e-37 127.3 0.0 3.1 2 1 1 3 3 3 3 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 KOO21733.1 - 1.1e-05 25.9 0.0 0.0011 19.6 0.0 2.3 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily WW PF00397.26 KOO21735.1 - 1.2e-25 89.2 20.4 3.3e-07 30.3 1.0 4.9 5 0 0 5 5 5 4 WW domain Peptidase_S28 PF05577.12 KOO21736.1 - 6.9e-48 163.5 0.4 9e-35 120.3 0.0 2.4 1 1 1 2 2 2 2 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 KOO21736.1 - 0.02 13.6 0.0 0.11 11.2 0.0 2.1 2 1 0 2 2 2 0 PS-10 peptidase S37 Ank_2 PF12796.7 KOO21737.1 - 1.2e-69 230.9 23.2 7.3e-16 58.5 0.8 6.8 2 1 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO21737.1 - 6.7e-47 157.3 19.2 3.9e-10 40.0 0.1 9.3 5 2 4 10 10 10 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO21737.1 - 2.6e-37 126.4 36.2 1.7e-05 25.0 0.8 12.0 1 1 11 12 12 12 11 Ankyrin repeats (many copies) Pkinase PF00069.25 KOO21737.1 - 1.3e-28 100.1 0.0 2.4e-28 99.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_3 PF13606.6 KOO21737.1 - 5.1e-26 87.9 34.8 0.04 14.5 0.0 12.5 12 1 1 13 13 13 10 Ankyrin repeat Pkinase_Tyr PF07714.17 KOO21737.1 - 8.3e-25 87.5 0.0 1.5e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 KOO21737.1 - 4.6e-24 83.8 62.6 0.00043 20.6 0.4 12.4 10 2 2 12 12 12 10 Ankyrin repeat SR1P PF13790.6 KOO21737.1 - 9.2e-05 22.5 7.9 5.9 7.1 0.0 6.8 9 0 0 9 9 9 2 SR1 protein Kinesin PF00225.23 KOO21738.1 - 3e-21 75.7 0.0 7.5e-21 74.4 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain TPR_12 PF13424.6 KOO21738.1 - 2.9e-10 40.3 1.1 4.6e-09 36.5 1.9 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21738.1 - 4.2e-06 26.4 0.2 0.001 18.9 0.1 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO21738.1 - 3.3e-05 23.6 0.8 0.074 12.9 0.3 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO21738.1 - 0.00011 21.6 2.0 0.0038 16.6 0.0 2.4 2 0 0 2 2 2 1 MalT-like TPR region TPR_2 PF07719.17 KOO21738.1 - 0.06 13.5 6.6 0.4 10.9 0.3 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21738.1 - 0.088 13.1 14.4 0.067 13.4 1.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21738.1 - 0.4 10.6 9.4 2.9 7.9 0.3 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat NPV_P10 PF05531.12 KOO21738.1 - 0.51 10.8 3.8 21 5.7 0.4 3.3 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 KOO21738.1 - 1.8 8.6 3.8 18 5.3 3.8 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HSBP1 PF06825.12 KOO21738.1 - 4.2 7.3 7.3 0.71 9.8 2.0 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 UPF0242 PF06785.11 KOO21738.1 - 4.2 7.4 11.5 12 5.9 11.5 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fzo_mitofusin PF04799.13 KOO21738.1 - 5 6.6 7.6 37 3.8 0.0 2.5 1 1 0 2 2 2 0 fzo-like conserved region Golgin_A5 PF09787.9 KOO21738.1 - 6.9 6.0 17.2 0.28 10.6 11.1 1.7 2 0 0 2 2 2 0 Golgin subfamily A member 5 Spc7 PF08317.11 KOO21738.1 - 8.4 5.2 20.5 8.4 5.2 15.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Porphobil_deam PF01379.20 KOO21739.1 - 3.1e-74 248.9 0.0 4.2e-74 248.5 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 KOO21739.1 - 1.6e-16 60.4 0.3 3e-16 59.6 0.3 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain BAT PF15915.5 KOO21739.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 GAF and HTH_10 associated domain Pkinase PF00069.25 KOO21741.1 - 1.1e-61 208.5 0.0 1.5e-61 208.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO21741.1 - 3.8e-34 116.6 0.1 8.1e-17 61.1 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO21741.1 - 4.9e-28 98.1 0.0 7.8e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO21741.1 - 6.9e-05 22.3 0.0 0.0007 19.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOO21741.1 - 0.061 12.3 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain bZIP_1 PF00170.21 KOO21741.1 - 0.46 10.6 3.3 0.85 9.8 3.3 1.5 1 0 0 1 1 1 0 bZIP transcription factor TerD PF02342.18 KOO21742.1 - 1.6e-58 197.3 0.0 7.9e-30 103.7 0.0 2.1 2 0 0 2 2 2 2 TerD domain C2 PF00168.30 KOO21742.1 - 5.3e-16 58.8 0.0 8.4e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 C2 domain RRM_1 PF00076.22 KOO21743.1 - 3.4e-20 71.6 0.0 1.5e-10 40.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 KOO21747.1 - 8.7e-58 195.7 0.0 1.1e-57 195.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21747.1 - 2.5e-26 92.5 0.0 7.1e-26 91.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO21747.1 - 0.0021 18.1 0.7 0.0098 15.8 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO21747.1 - 0.053 12.5 0.0 0.15 10.9 0.0 1.6 2 1 0 2 2 2 0 Haspin like kinase domain Pkinase_fungal PF17667.1 KOO21747.1 - 0.2 10.4 0.0 0.27 9.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 KOO21747.1 - 0.22 11.1 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 US30 PF17624.2 KOO21748.1 - 0.0029 16.7 0.2 0.0029 16.7 0.2 2.2 2 0 0 2 2 2 1 Family of unknown function Nucleotid_trans PF03407.16 KOO21749.1 - 3.6e-13 50.0 0.0 5.4e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Nucleotid_trans PF03407.16 KOO21750.1 - 1.9e-09 37.8 0.6 2.7e-09 37.3 0.6 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Mito_carr PF00153.27 KOO21751.1 - 8.9e-22 76.8 9.6 1.5e-08 34.4 0.1 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein FinO_N PF12602.8 KOO21752.1 - 0.016 15.5 0.0 0.049 13.9 0.0 1.8 1 0 0 1 1 1 0 Fertility inhibition protein N terminal TetR_C_11 PF16859.5 KOO21752.1 - 3.1 8.1 6.4 0.66 10.3 0.3 2.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Glyco_trans_1_4 PF13692.6 KOO21753.1 - 1.7e-08 35.0 0.0 3.5e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 KOO21753.1 - 0.0001 21.9 0.0 0.00036 20.1 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KOO21753.1 - 0.0027 18.1 0.0 0.0064 16.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Flavi_capsid PF01003.19 KOO21754.1 - 0.014 15.1 0.2 0.025 14.3 0.2 1.3 1 0 0 1 1 1 0 Flavivirus capsid protein C DUF5595 PF18077.1 KOO21755.1 - 5.2e-12 45.7 0.4 5.2e-12 45.7 0.4 4.4 4 1 1 5 5 5 1 Domain of unknown function (DUF5595) Ndc80_HEC PF03801.13 KOO21755.1 - 2e-11 43.8 0.0 4.5e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 HEC/Ndc80p family HALZ PF02183.18 KOO21755.1 - 0.001 19.3 1.6 3.1 8.1 0.0 3.9 3 0 0 3 3 3 2 Homeobox associated leucine zipper GAS PF13851.6 KOO21755.1 - 0.0012 18.2 38.0 0.0013 18.1 13.7 3.5 2 2 1 3 3 3 3 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 KOO21755.1 - 0.037 11.6 37.5 0.11 10.0 14.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_31 PF13614.6 KOO21755.1 - 0.59 10.0 2.9 6.8 6.6 0.0 2.6 2 1 1 3 3 3 0 AAA domain Adhesin_P1_N PF18652.1 KOO21755.1 - 0.75 9.9 7.7 0.1 12.6 0.7 3.3 3 0 0 3 3 3 0 Adhesin P1 N-terminal domain ATG16 PF08614.11 KOO21755.1 - 1.1 9.4 50.6 0.015 15.5 24.4 2.8 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) USP8_interact PF08941.10 KOO21755.1 - 2.8 7.7 11.2 0.13 12.1 2.1 2.9 2 2 1 3 3 3 0 USP8 interacting Filament PF00038.21 KOO21755.1 - 3.5 7.1 43.7 0.14 11.7 19.6 3.9 2 2 1 4 4 4 0 Intermediate filament protein Gp58 PF07902.11 KOO21755.1 - 6.3 5.0 12.3 0.51 8.6 0.1 3.0 2 1 1 3 3 3 0 gp58-like protein APG6_N PF17675.1 KOO21755.1 - 6.6 7.3 59.1 0.26 11.8 19.1 5.1 2 2 1 3 3 2 0 Apg6 coiled-coil region WASH-7_C PF14746.6 KOO21755.1 - 9.8 5.8 9.4 0.49 10.1 1.5 2.4 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal EF-hand_1 PF00036.32 KOO21756.1 - 4.4e-09 35.2 5.4 0.0008 18.8 0.3 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO21756.1 - 7.1e-09 36.0 1.4 1.2e-08 35.3 0.3 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO21756.1 - 8.3e-09 35.2 1.8 9.3e-08 31.8 0.1 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21756.1 - 1.4e-07 30.9 2.6 8.5e-05 22.2 0.2 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO21756.1 - 4.7e-06 25.9 3.3 0.053 13.0 0.4 2.9 3 0 0 3 3 3 2 EF hand cNMP_binding PF00027.29 KOO21756.1 - 9.2e-05 22.4 0.0 0.13 12.4 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Com_YlbF PF06133.11 KOO21756.1 - 1.7 9.3 5.3 1.3 9.6 0.1 2.7 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA Nop53 PF07767.11 KOO21757.1 - 1.6e-38 133.1 22.7 2.1e-38 132.7 22.7 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.14 KOO21757.1 - 0.44 8.8 17.3 0.65 8.2 17.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DAGK_cat PF00781.24 KOO21758.1 - 4.6e-28 97.4 0.4 6.9e-28 96.8 0.4 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ank_5 PF13857.6 KOO21759.1 - 7.5e-15 54.8 0.4 4.4e-08 33.3 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO21759.1 - 5e-13 49.4 0.1 1.2e-12 48.2 0.1 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO21759.1 - 2.2e-12 46.8 0.9 1.3e-06 28.5 0.3 3.6 3 1 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KOO21759.1 - 5e-11 42.9 0.0 1.6e-09 38.1 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO21759.1 - 8.8e-08 31.9 0.0 0.002 18.4 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat TPR_14 PF13428.6 KOO21760.1 - 1.3e-18 66.1 60.9 3.3e-06 27.5 0.3 11.3 5 3 6 12 12 11 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21760.1 - 1.5e-18 65.4 39.6 0.0013 18.7 0.6 10.8 11 1 1 12 12 12 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21760.1 - 1.6e-15 55.9 3.0 0.017 15.3 0.0 7.7 6 1 2 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21760.1 - 6.9e-15 55.4 51.0 6.7e-07 29.9 0.7 8.3 6 2 2 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21760.1 - 3.5e-14 52.9 40.3 4.7e-07 30.0 0.6 7.7 5 2 3 8 8 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 KOO21760.1 - 6.4e-12 45.0 9.9 0.035 14.5 0.0 7.3 8 1 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21760.1 - 7.1e-12 44.6 9.4 0.018 14.8 0.0 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21760.1 - 1.3e-09 38.4 34.1 0.0089 16.5 0.2 7.5 6 3 2 8 8 8 4 Tetratricopeptide repeat TPR_15 PF13429.6 KOO21760.1 - 1.4e-06 27.8 10.7 1.4e-06 27.8 10.7 3.4 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21760.1 - 1.7e-06 27.7 19.7 0.051 13.6 0.1 7.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21760.1 - 7.9e-05 22.3 11.1 0.7 9.6 0.0 6.7 6 2 2 8 8 7 2 TPR repeat TPR_9 PF13371.6 KOO21760.1 - 0.0018 18.4 30.8 1.4 9.1 0.1 6.5 2 2 2 6 6 6 3 Tetratricopeptide repeat FAT PF02259.23 KOO21760.1 - 0.004 16.4 3.1 0.11 11.7 0.1 2.9 2 1 0 2 2 2 1 FAT domain Suf PF05843.14 KOO21760.1 - 0.0093 16.0 0.0 0.099 12.6 0.0 2.5 2 1 1 3 3 2 1 Suppressor of forked protein (Suf) ANAPC3 PF12895.7 KOO21760.1 - 0.069 13.4 0.1 0.069 13.4 0.1 4.1 4 1 1 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 KOO21760.1 - 0.078 13.1 1.9 4.1 7.6 0.0 3.9 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.10 KOO21760.1 - 0.12 11.3 0.3 8.7 5.2 0.0 2.2 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.6 KOO21760.1 - 0.15 12.4 4.4 30 5.0 0.0 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO21760.1 - 0.2 12.3 24.7 75 4.3 0.1 9.3 8 2 1 9 9 9 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KOO21760.1 - 0.22 11.2 10.2 0.1 12.2 0.3 4.0 4 1 0 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) Mad3_BUB1_I PF08311.12 KOO21760.1 - 2.5 8.1 6.1 99 2.9 0.3 5.1 5 2 0 5 5 4 0 Mad3/BUB1 homology region 1 Wzy_C_2 PF11846.8 KOO21760.1 - 3.8 7.4 7.8 3.6 7.5 0.1 3.9 3 1 1 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal FYDLN_acid PF09538.10 KOO21761.1 - 0.0013 19.4 0.2 0.0019 18.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) GP68 PF17469.2 KOO21761.1 - 1.5 9.2 4.8 0.41 11.1 1.0 2.2 2 1 0 2 2 2 0 Phage protein Gp68 Bac_surface_Ag PF01103.23 KOO21762.1 - 1.3e-36 126.7 0.0 1.6e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 Surface antigen DUF3638 PF12340.8 KOO21764.1 - 6.7e-35 120.5 0.0 1.6e-34 119.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO21764.1 - 2e-15 55.8 0.1 3.3e-14 52.0 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) Mod_r PF07200.13 KOO21764.1 - 0.024 14.8 4.6 2.3 8.3 0.0 3.1 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TetR_C_13 PF16925.5 KOO21764.1 - 0.042 13.8 0.1 0.2 11.6 0.1 2.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain BACK PF07707.15 KOO21764.1 - 0.043 13.9 0.0 0.75 9.9 0.0 2.9 2 0 0 2 2 2 0 BTB And C-terminal Kelch DHR10 PF18595.1 KOO21764.1 - 0.11 12.6 7.3 0.031 14.3 0.9 3.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Prefoldin_2 PF01920.20 KOO21764.1 - 0.12 12.3 5.5 0.45 10.5 0.1 3.8 3 1 1 4 4 4 0 Prefoldin subunit MT PF12777.7 KOO21764.1 - 0.17 10.8 1.3 4.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Microtubule-binding stalk of dynein motor Bap31_Bap29_C PF18035.1 KOO21764.1 - 0.28 11.2 5.1 0.38 10.8 2.7 2.5 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain SPAM PF02090.15 KOO21764.1 - 4.5 7.1 7.4 0.46 10.3 0.9 2.6 3 0 0 3 3 3 0 Salmonella surface presentation of antigen gene type M protein Laminin_G_3 PF13385.6 KOO21766.1 - 0.00014 22.1 0.0 0.00027 21.1 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DnaJ PF00226.31 KOO21767.1 - 8.1e-25 86.7 1.9 8.1e-25 86.7 1.9 2.0 2 0 0 2 2 2 1 DnaJ domain TPR_2 PF07719.17 KOO21767.1 - 2.2e-12 46.1 7.7 9.6e-05 22.2 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21767.1 - 2.8e-11 42.7 5.1 7e-05 22.5 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21767.1 - 1.7e-09 38.1 0.5 0.0065 17.0 0.0 3.7 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO21767.1 - 3.3e-08 33.7 6.5 0.041 14.7 0.0 5.0 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21767.1 - 1.3e-05 24.8 0.1 0.58 9.9 0.0 3.6 3 0 0 3 3 3 2 TPR repeat TPR_12 PF13424.6 KOO21767.1 - 1.6e-05 25.1 7.8 0.074 13.4 0.5 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21767.1 - 6.3e-05 23.5 1.0 0.51 11.0 0.0 4.2 2 1 2 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO21767.1 - 0.00012 21.4 0.7 0.1 11.8 0.0 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21767.1 - 0.00029 20.8 5.9 0.68 10.3 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO21767.1 - 0.0015 18.7 3.7 0.0027 17.9 0.2 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KOO21767.1 - 0.032 14.3 5.8 31 4.9 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO21767.1 - 0.25 11.5 4.4 0.67 10.1 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO21767.1 - 0.46 11.2 4.5 5.6 7.8 0.0 4.2 5 0 0 5 5 3 0 Tetratricopeptide repeat DUF2116 PF09889.9 KOO21767.1 - 5.2 7.1 6.5 2.7 8.1 3.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) ASH PF15780.5 KOO21768.1 - 1.3e-35 121.5 1.3 1.2e-05 25.4 0.2 10.0 10 0 0 10 10 10 6 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 KOO21768.1 - 7.7e-19 67.6 0.0 0.00044 20.1 0.0 8.5 11 0 0 11 11 11 4 MSP (Major sperm protein) domain PapD-like PF14874.6 KOO21768.1 - 1e-09 38.4 0.4 0.62 10.3 0.0 5.9 6 0 0 6 6 6 3 Flagellar-associated PapD-like DUF1573 PF07610.11 KOO21768.1 - 3e-08 33.6 0.0 1.3 9.0 0.1 6.4 8 0 0 8 8 8 3 Protein of unknown function (DUF1573) TMEM131_like PF12371.8 KOO21768.1 - 1.9e-06 28.0 11.7 0.045 14.0 0.1 6.9 8 0 0 8 8 8 3 Transmembrane protein 131-like DUF5001 PF16392.5 KOO21768.1 - 3e-06 27.0 0.0 8.9 6.3 0.0 6.8 8 0 0 8 8 8 1 Ig-like domain PapD_N PF00345.20 KOO21768.1 - 0.01 15.8 0.0 9.8 6.1 0.0 4.2 5 0 0 5 5 5 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain Fn3-like PF14310.6 KOO21768.1 - 0.083 13.0 0.0 2.1 8.5 0.0 3.0 3 0 0 3 3 3 0 Fibronectin type III-like domain EF-hand_6 PF13405.6 KOO21769.1 - 0.00029 20.5 0.4 0.0012 18.6 0.0 2.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO21769.1 - 0.0028 17.1 0.0 0.047 13.3 0.0 2.5 2 0 0 2 2 2 1 EF hand Laminin_G_3 PF13385.6 KOO21769.1 - 0.0048 17.1 0.0 0.0073 16.5 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily SUKH-3 PF14433.6 KOO21769.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 SUKH-3 immunity protein Pkinase PF00069.25 KOO21770.1 - 1.8e-62 211.1 0.0 4.1e-62 209.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21770.1 - 4.1e-39 134.4 0.0 6e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SnoaL PF07366.12 KOO21770.1 - 7.3e-11 42.0 0.2 2.5e-10 40.2 0.0 2.1 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase PAS_9 PF13426.7 KOO21770.1 - 3.3e-08 33.7 0.0 0.00047 20.4 0.0 4.1 4 0 0 4 4 4 2 PAS domain Kinase-like PF14531.6 KOO21770.1 - 0.001 18.4 0.0 0.062 12.6 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO21770.1 - 0.14 11.0 0.0 0.31 9.8 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase JAB PF01398.21 KOO21772.1 - 2.5e-14 53.3 0.0 4.4e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UCR_hinge PF02320.16 KOO21772.1 - 0.16 12.2 2.2 0.31 11.3 0.2 2.2 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein ZapB PF06005.12 KOO21772.1 - 0.41 11.1 4.4 0.81 10.2 4.4 1.4 1 0 0 1 1 1 0 Cell division protein ZapB TRM PF02005.16 KOO21773.1 - 2.2e-11 43.5 0.1 1e-10 41.4 0.1 1.8 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase Abhydrolase_9_N PF15420.6 KOO21775.1 - 0.0076 16.3 1.5 1 9.3 0.0 2.1 2 0 0 2 2 2 2 Alpha/beta-hydrolase family N-terminus p25-alpha PF05517.12 KOO21777.1 - 2.6e-06 27.7 25.1 3.4 7.8 0.0 11.3 12 0 0 12 12 12 4 p25-alpha DnaI_N PF07319.11 KOO21777.1 - 0.12 13.1 5.6 5.7 7.7 0.1 4.4 4 0 0 4 4 4 0 Primosomal protein DnaI N-terminus DUF4041 PF13250.6 KOO21777.1 - 0.37 10.7 1.7 51 3.8 0.0 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4041) EF-hand_1 PF00036.32 KOO21778.1 - 0.00021 20.6 17.0 0.19 11.4 0.0 10.4 11 0 0 11 11 11 1 EF hand Asp2 PF16929.5 KOO21778.1 - 0.091 11.7 0.1 0.16 10.9 0.1 1.3 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Abhydrolase_6 PF12697.7 KOO21778.1 - 0.14 12.7 0.1 0.51 10.9 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family UPF0227 PF05728.12 KOO21778.1 - 0.17 11.8 0.0 0.41 10.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) U-box PF04564.15 KOO21781.1 - 1.1e-15 57.6 0.0 1.6e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO21781.1 - 0.00015 21.5 0.0 0.00026 20.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO21781.1 - 0.013 15.6 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Med3 PF11593.8 KOO21781.1 - 0.046 12.9 12.5 0.056 12.6 12.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Peptidase_S30 PF01577.16 KOO21781.1 - 0.23 11.0 4.1 0.35 10.4 4.1 1.2 1 0 0 1 1 1 0 Potyvirus P1 protease SAPS PF04499.15 KOO21781.1 - 0.89 8.3 2.8 0.97 8.1 2.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NPR3 PF03666.13 KOO21781.1 - 1.1 8.0 3.4 1.2 7.9 3.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GREB1 PF15782.5 KOO21781.1 - 1.8 5.6 4.0 1.9 5.5 4.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 KOO21781.1 - 3 6.5 7.3 3.6 6.3 7.3 1.2 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 KOO21781.1 - 3.1 7.2 4.6 4.1 6.9 4.6 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Rtf2 PF04641.12 KOO21781.1 - 4.3 6.6 19.9 24 4.2 0.0 2.4 1 1 1 2 2 2 0 Rtf2 RING-finger DUF4050 PF13259.6 KOO21781.1 - 4.7 7.5 9.8 16 5.7 9.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4050) TIG PF01833.24 KOO21782.1 - 4.7e-44 148.4 4.3 9.2e-09 35.3 0.1 5.1 5 0 0 5 5 5 5 IPT/TIG domain HSP90 PF00183.18 KOO21783.1 - 7.2e-157 523.4 0.0 4.6e-156 520.7 0.0 1.8 1 1 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.6 KOO21783.1 - 8.8e-13 48.3 0.1 1.9e-12 47.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOO21783.1 - 3.7e-11 43.5 0.1 6.5e-11 42.7 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1198 PF06711.11 KOO21783.1 - 0.0097 16.0 0.1 0.023 14.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1198) Bac_DNA_binding PF00216.21 KOO21783.1 - 4.4 7.6 5.4 19 5.6 0.1 3.4 4 0 0 4 4 4 0 Bacterial DNA-binding protein Ank_2 PF12796.7 KOO21784.1 - 3.1e-05 24.5 0.1 7.9e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) zf-MYND PF01753.18 KOO21784.1 - 0.00024 21.1 21.1 0.00077 19.5 21.1 1.9 1 1 0 1 1 1 1 MYND finger Ank_4 PF13637.6 KOO21784.1 - 0.00052 20.5 0.0 0.0021 18.6 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO21784.1 - 0.0026 18.0 0.3 0.013 15.8 0.2 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) IU_nuc_hydro PF01156.19 KOO21785.1 - 9.1e-10 38.6 0.7 2.7e-05 23.9 0.1 2.6 2 1 0 2 2 2 2 Inosine-uridine preferring nucleoside hydrolase Collagen PF01391.18 KOO21785.1 - 0.00079 19.1 5.7 0.0017 18.1 5.7 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) YqjK PF13997.6 KOO21785.1 - 0.12 12.6 1.6 26 5.1 0.0 3.5 3 0 0 3 3 3 0 YqjK-like protein Dynein_light PF01221.18 KOO21786.1 - 2.5e-43 146.3 2.1 2.8e-43 146.1 2.1 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Imm48 PF15574.6 KOO21786.1 - 0.052 13.3 0.1 0.073 12.8 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 48 SPA PF08616.10 KOO21787.1 - 7e-06 26.0 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 KOO21787.1 - 2.2e-05 23.4 0.0 4.1e-05 22.5 0.0 1.4 2 0 0 2 2 2 1 Transport protein Avl9 Afi1 PF07792.12 KOO21787.1 - 0.3 11.6 0.0 0.46 11.0 0.0 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking adh_short PF00106.25 KOO21788.1 - 2.1e-20 73.0 0.1 2.7e-19 69.4 0.1 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO21788.1 - 9.1e-12 45.0 0.4 1.3e-10 41.3 0.2 2.6 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO21788.1 - 0.0004 20.3 0.1 0.00085 19.3 0.1 1.6 1 0 0 1 1 1 1 KR domain F-box-like PF12937.7 KOO21788.1 - 0.00095 19.0 0.0 0.0028 17.5 0.0 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 KOO21788.1 - 0.0015 18.9 0.0 0.056 13.9 0.0 2.8 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO21788.1 - 0.065 13.8 0.1 69 4.6 0.1 4.2 3 1 0 3 3 3 0 Leucine Rich Repeat EF-hand_1 PF00036.32 KOO21790.1 - 3.9e-14 51.1 0.0 2.2e-06 26.8 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21790.1 - 2.1e-11 43.5 0.3 4.9e-11 42.3 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 KOO21790.1 - 2.5e-11 43.8 0.0 4.2e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO21790.1 - 1e-09 37.6 0.0 0.00016 21.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO21790.1 - 2.5e-08 33.0 0.1 0.00078 18.8 0.0 2.4 2 0 0 2 2 2 2 EF hand Methyltransf_21 PF05050.12 KOO21790.1 - 2.1e-06 27.9 0.0 3.8e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain EF-hand_9 PF14658.6 KOO21790.1 - 7.9e-06 26.1 0.0 1.8e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO21790.1 - 0.057 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO21790.1 - 0.14 12.5 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TPR_11 PF13414.6 KOO21791.1 - 8.9e-15 54.1 0.5 9e-08 31.7 0.0 4.4 4 1 0 4 4 4 3 TPR repeat TPR_17 PF13431.6 KOO21791.1 - 6.4e-08 32.5 0.8 0.51 10.8 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO21791.1 - 3.4e-07 30.7 1.2 0.00075 20.0 0.2 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO21791.1 - 9e-07 28.5 2.1 0.014 15.2 0.0 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21791.1 - 1.3e-05 24.9 7.0 0.058 13.5 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO21791.1 - 2e-05 25.0 2.5 0.017 15.9 0.0 4.3 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21791.1 - 2.1e-05 25.1 6.1 0.21 12.2 1.8 3.7 2 1 3 5 5 5 4 Tetratricopeptide repeat BTAD PF03704.17 KOO21791.1 - 0.0004 20.8 0.7 0.056 13.9 0.0 2.8 2 1 0 3 3 3 1 Bacterial transcriptional activator domain TPR_8 PF13181.6 KOO21791.1 - 0.0038 17.3 1.9 45 4.6 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21791.1 - 0.11 12.8 0.2 4.5 7.6 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 KOO21792.1 - 2e-13 48.8 0.0 1.5e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO21792.1 - 4.5e-12 44.9 0.0 4.6e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO21792.1 - 2.8e-10 40.5 0.0 3.8e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO21792.1 - 4.1e-10 38.7 0.4 4.2e-05 22.8 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21792.1 - 8.3e-08 32.0 0.0 3.8e-05 23.4 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair Sun2_CC2 PF18580.1 KOO21792.1 - 0.0064 16.7 0.1 0.01 16.0 0.1 1.3 1 0 0 1 1 1 1 SUN2 coiled coil domain 2 EF-hand_10 PF14788.6 KOO21792.1 - 0.01 15.7 0.0 2.2 8.2 0.0 2.1 2 0 0 2 2 2 0 EF hand DUF724 PF05266.14 KOO21793.1 - 2 8.2 8.2 4.1 7.2 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) GpcrRhopsn4 PF10192.9 KOO21794.1 - 9.2e-36 123.6 0.1 2.1e-35 122.4 0.1 1.6 1 1 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain CRAL_TRIO PF00650.20 KOO21797.1 - 1.1e-13 51.2 0.1 1.5e-13 50.8 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain PDZ_6 PF17820.1 KOO21798.1 - 8.4e-05 22.3 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO21798.1 - 0.00044 20.5 0.0 0.00091 19.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO21798.1 - 0.16 12.3 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 PDZ domain TALPID3 PF15324.6 KOO21798.1 - 6.4 4.3 10.9 8.1 4.0 10.9 1.1 1 0 0 1 1 1 0 Hedgehog signalling target ETF PF01012.21 KOO21799.1 - 0.0018 18.2 3.1 0.0049 16.8 3.0 1.7 1 1 0 1 1 1 1 Electron transfer flavoprotein domain HeH PF12949.7 KOO21800.1 - 0.0028 17.3 0.0 0.0046 16.6 0.0 1.4 1 0 0 1 1 1 1 HeH/LEM domain SAP PF02037.27 KOO21800.1 - 0.017 14.9 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 SAP domain HSP20 PF00011.21 KOO21802.1 - 1.9e-13 50.4 0.1 3.6e-13 49.5 0.1 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KOO21802.1 - 0.00083 18.9 0.0 0.0029 17.1 0.0 1.9 1 1 0 1 1 1 1 HSP20-like domain found in ArsA MMR_HSR1 PF01926.23 KOO21802.1 - 0.001 19.1 0.1 0.0039 17.3 0.1 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GBP PF02263.19 KOO21802.1 - 0.0011 18.3 1.8 0.0077 15.5 0.0 2.1 1 1 1 2 2 2 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 KOO21802.1 - 0.0048 17.0 1.2 1.1 9.3 0.1 2.9 3 0 0 3 3 3 2 Dynamin family HSP20 PF00011.21 KOO21803.1 - 1.3e-13 51.0 0.1 2.3e-13 50.2 0.1 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KOO21803.1 - 0.00049 19.6 0.0 0.0019 17.7 0.0 2.0 1 1 0 1 1 1 1 HSP20-like domain found in ArsA GBP PF02263.19 KOO21803.1 - 0.0025 17.1 0.0 0.0043 16.4 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 KOO21803.1 - 0.023 14.8 0.0 0.089 12.9 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOO21803.1 - 0.15 12.1 0.1 0.76 9.8 0.1 2.0 2 0 0 2 2 2 0 Dynamin family SET PF00856.28 KOO21804.1 - 0.011 16.2 0.0 0.026 14.9 0.0 1.6 1 1 0 1 1 1 0 SET domain Methyltransf_21 PF05050.12 KOO21804.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase FkbM domain Gly-zipper_OmpA PF13436.6 KOO21805.1 - 0.15 11.9 9.8 0.56 10.0 9.8 2.0 1 0 0 1 1 1 0 Glycine-zipper domain RelA_SpoT PF04607.17 KOO21806.1 - 4.2e-20 72.2 0.0 5.8e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins Orthopox_C10L PF07020.11 KOO21806.1 - 0.14 12.9 0.1 0.24 12.2 0.1 1.4 1 0 0 1 1 1 0 Orthopoxvirus C10L protein CRAL_TRIO_2 PF13716.6 KOO21809.1 - 1.4e-17 64.1 0.1 1.7e-17 63.9 0.1 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KOO21809.1 - 7.4e-05 22.5 0.0 9.6e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain Nuc_sug_transp PF04142.15 KOO21811.1 - 3.3e-25 88.9 11.3 5e-25 88.3 11.3 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EOS1 PF12326.8 KOO21811.1 - 3.6 7.5 8.2 6.7 6.6 3.5 2.3 2 0 0 2 2 2 0 N-glycosylation protein EamA PF00892.20 KOO21811.1 - 4.6 7.4 20.5 1.9 8.7 0.9 2.7 2 1 0 2 2 2 0 EamA-like transporter family Chloroa_b-bind PF00504.21 KOO21812.1 - 4.5e-37 128.1 0.0 5.6e-37 127.7 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Ustilago_mating PF05722.12 KOO21814.1 - 0.35 10.4 3.5 0.38 10.2 3.5 1.0 1 0 0 1 1 1 0 Ustilago B locus mating-type protein C2 PF00168.30 KOO21815.1 - 2.9e-15 56.4 0.0 5.8e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain MMS1_N PF10433.9 KOO21816.1 - 1.8e-152 508.4 0.0 2.6e-152 507.9 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KOO21816.1 - 1.3e-85 287.6 0.0 8.6e-85 284.9 0.0 2.1 2 0 0 2 2 2 1 CPSF A subunit region EF-hand_1 PF00036.32 KOO21816.1 - 1.4e-10 40.0 1.1 0.0041 16.6 0.2 3.7 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO21816.1 - 2e-09 36.6 1.7 0.0016 18.2 0.1 4.0 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO21816.1 - 1.4e-07 31.8 1.8 1.4e-05 25.5 0.3 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO21816.1 - 5.8e-05 22.4 3.4 0.028 13.9 0.2 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO21816.1 - 0.0025 17.6 6.1 0.0053 16.6 1.9 3.2 2 2 1 3 3 3 2 EF-hand domain pair NIF PF03031.18 KOO21817.1 - 1.3e-52 177.7 0.3 1.7e-52 177.3 0.3 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Ank_4 PF13637.6 KOO21817.1 - 3.6e-19 68.9 0.8 4.9e-07 30.2 0.1 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO21817.1 - 8.4e-19 68.0 0.0 9.2e-09 35.8 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO21817.1 - 1.2e-17 63.5 2.4 5.2e-07 29.8 0.0 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 KOO21817.1 - 4.4e-15 54.3 0.2 0.00017 21.8 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO21817.1 - 8.8e-14 51.4 0.5 4.8e-05 23.6 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) R3H PF01424.22 KOO21818.1 - 1.2e-12 47.6 0.1 2e-12 46.9 0.1 1.4 1 0 0 1 1 1 1 R3H domain MAPEG PF01124.18 KOO21818.1 - 1.4e-06 28.2 0.0 2.9e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 MAPEG family UBA PF00627.31 KOO21818.1 - 0.0039 17.1 0.0 0.13 12.2 0.0 2.5 2 0 0 2 2 2 1 UBA/TS-N domain UBA_4 PF14555.6 KOO21818.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain DUF4490 PF14892.6 KOO21819.1 - 0.0054 16.8 0.0 0.015 15.4 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4490) LRR_6 PF13516.6 KOO21820.1 - 1.6e-13 49.5 13.7 0.0069 16.4 0.0 8.4 8 0 0 8 8 8 5 Leucine Rich repeat LRR_1 PF00560.33 KOO21820.1 - 0.00026 21.1 2.4 51 5.0 0.1 6.0 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO21820.1 - 0.00031 21.1 6.6 5.4 7.6 0.2 4.9 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) Skp1 PF01466.19 KOO21820.1 - 0.031 14.4 0.0 0.12 12.5 0.0 2.0 2 0 0 2 2 2 0 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 KOO21820.1 - 0.18 12.0 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain LRR_8 PF13855.6 KOO21820.1 - 0.45 10.3 6.5 25 4.7 0.3 5.0 5 1 0 5 5 5 0 Leucine rich repeat TIG PF01833.24 KOO21822.1 - 1.3e-23 82.9 4.7 4e-08 33.2 0.1 4.6 5 0 0 5 5 5 3 IPT/TIG domain TIG_plexin PF17960.1 KOO21822.1 - 6e-07 29.4 0.0 0.089 12.8 0.0 3.6 3 0 0 3 3 3 2 TIG domain DUF4350 PF14258.6 KOO21822.1 - 0.07 13.6 0.1 0.61 10.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) EF_TS PF00889.19 KOO21823.1 - 1.8e-33 115.9 5.0 5.4e-33 114.3 5.0 2.2 1 1 0 1 1 1 1 Elongation factor TS Bromo_TP PF07524.13 KOO21823.1 - 0.0012 18.8 0.1 0.12 12.4 0.0 3.1 3 0 0 3 3 3 1 Bromodomain associated TOBE_2 PF08402.10 KOO21823.1 - 0.058 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 TOBE domain Arb1 PF09692.10 KOO21823.1 - 0.059 12.5 0.2 0.072 12.3 0.2 1.1 1 0 0 1 1 1 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Cupin_8 PF13621.6 KOO21824.1 - 1.5e-29 103.5 0.9 6.9e-29 101.3 0.9 1.9 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO21824.1 - 0.0016 18.0 0.0 0.024 14.1 0.0 2.2 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 KOO21824.1 - 0.0023 18.3 0.1 0.0047 17.3 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Inositol_P PF00459.25 KOO21825.1 - 1.4e-46 159.2 0.1 1.7e-46 159.0 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family RRP7 PF12923.7 KOO21826.1 - 4.3e-27 94.6 9.1 5.5e-27 94.3 9.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain TMA7 PF09072.10 KOO21826.1 - 1.6 9.6 9.0 7.8 7.4 5.8 2.3 1 1 0 2 2 2 0 Translation machinery associated TMA7 DUF5339 PF17274.2 KOO21826.1 - 1.8 9.5 7.0 0.35 11.8 2.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5339) Chromo PF00385.24 KOO21827.1 - 1.3e-12 47.4 0.4 1.2e-11 44.3 0.4 2.3 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 KOO21827.1 - 8.1e-08 32.3 0.0 0.014 15.5 0.0 2.5 2 0 0 2 2 2 2 Chromo shadow domain ARID PF01388.21 KOO21827.1 - 0.00065 20.3 0.0 0.0014 19.3 0.0 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain VID27_N PF17748.1 KOO21827.1 - 0.051 13.4 2.7 0.095 12.5 2.7 1.5 1 0 0 1 1 1 0 VID27 N-terminal region FRQ PF09421.10 KOO21827.1 - 0.24 9.4 6.0 0.3 9.0 6.0 1.1 1 0 0 1 1 1 0 Frequency clock protein GUN4 PF05419.12 KOO21828.1 - 1.3e-42 145.2 0.0 1.6e-42 144.9 0.0 1.1 1 0 0 1 1 1 1 GUN4-like UPF0172 PF03665.13 KOO21829.1 - 2.6e-45 154.9 0.0 3.2e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Aminotran_1_2 PF00155.21 KOO21830.1 - 0.0034 16.6 0.0 0.4 9.8 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II Methyltrans_RNA PF04452.14 KOO21831.1 - 3e-41 141.2 0.0 4.4e-37 127.6 0.0 2.1 1 1 1 2 2 2 2 RNA methyltransferase Glyco_hydro_79n PF03662.14 KOO21831.1 - 1e-05 24.7 0.0 0.00022 20.3 0.0 2.5 2 1 0 2 2 2 1 Glycosyl hydrolase family 79, N-terminal domain Xpo1 PF08389.12 KOO21832.1 - 3.7e-05 23.8 0.0 0.031 14.4 0.0 4.1 4 0 0 4 4 4 1 Exportin 1-like protein Importin_rep_3 PF18806.1 KOO21832.1 - 0.0059 16.6 0.2 0.095 12.8 0.1 3.1 3 0 0 3 3 3 1 Importin 13 repeat IBN_N PF03810.19 KOO21832.1 - 0.12 12.3 0.0 0.4 10.6 0.0 2.0 1 0 0 1 1 1 0 Importin-beta N-terminal domain Transmemb_17 PF09799.9 KOO21833.1 - 6e-15 55.8 13.1 6.5e-15 55.6 12.6 1.3 1 1 0 1 1 1 1 Predicted membrane protein SBBP PF06739.11 KOO21835.1 - 6.2e-07 29.3 12.9 0.057 13.4 0.7 4.9 5 0 0 5 5 5 4 Beta-propeller repeat Lactamase_B PF00753.27 KOO21835.1 - 0.14 12.1 8.1 6.3 6.7 0.2 3.2 2 1 1 3 3 3 0 Metallo-beta-lactamase superfamily ACP_syn_III PF08545.10 KOO21835.1 - 0.58 10.1 9.4 20 5.1 0.2 3.4 2 1 1 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF3767 PF12597.8 KOO21835.1 - 5.7 6.8 8.1 14 5.5 0.1 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3767) Pkinase PF00069.25 KOO21837.1 - 5.5e-66 222.6 0.0 8.9e-66 221.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21837.1 - 9.7e-35 120.1 2.0 2.2e-34 118.9 0.9 2.0 2 1 1 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO21837.1 - 0.00018 20.9 1.0 0.003 16.9 1.2 2.2 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOO21837.1 - 0.0017 17.4 2.4 0.0043 16.1 2.4 1.6 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOO21837.1 - 0.068 13.1 0.0 0.14 12.0 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pribosyltran PF00156.27 KOO21838.1 - 5.6e-21 74.7 0.0 7e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 KOO21838.1 - 0.056 12.9 0.0 0.085 12.3 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase UPRTase PF14681.6 KOO21838.1 - 0.079 12.4 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase PAP_fibrillin PF04755.12 KOO21840.1 - 2.4e-09 37.4 0.0 9e-05 22.5 0.0 3.0 2 1 0 2 2 2 2 PAP_fibrillin DUF812 PF05667.11 KOO21842.1 - 0.13 11.1 5.1 0.2 10.5 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) EF-hand_7 PF13499.6 KOO21843.1 - 2.7e-12 47.0 0.1 5.7e-12 45.9 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO21843.1 - 2.8e-12 45.5 0.7 5.3e-05 22.8 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO21843.1 - 4.5e-12 44.6 3.6 4.3e-06 25.9 1.4 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO21843.1 - 3.7e-11 42.7 1.8 1.6e-06 27.8 0.2 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO21843.1 - 5.2e-08 32.0 3.2 0.0017 17.7 0.5 2.5 2 0 0 2 2 2 2 EF hand Kinesin PF00225.23 KOO21844.1 - 2.1e-61 207.7 0.0 2.7e-61 207.3 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO21844.1 - 1.1e-10 41.6 0.0 1.6e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 KOO21844.1 - 0.011 16.1 0.0 0.036 14.4 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Bac_DnaA PF00308.18 KOO21844.1 - 0.077 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein DUF87 PF01935.17 KOO21844.1 - 0.078 13.1 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain SAM_PNT PF02198.16 KOO21844.1 - 0.084 12.8 0.1 6.7 6.8 0.0 2.5 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain AAA_22 PF13401.6 KOO21844.1 - 0.092 13.0 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 KOO21844.1 - 0.24 10.5 0.1 0.4 9.8 0.1 1.2 1 0 0 1 1 1 0 PIF1-like helicase DUF713 PF05218.14 KOO21845.1 - 0.014 15.1 0.1 0.021 14.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF713) DUF4349 PF14257.6 KOO21845.1 - 0.019 14.4 4.2 0.022 14.2 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) FlxA PF14282.6 KOO21845.1 - 0.034 14.2 3.9 0.058 13.4 3.9 1.5 1 0 0 1 1 1 0 FlxA-like protein Phage_Mu_Gam PF07352.12 KOO21845.1 - 0.04 13.8 3.0 0.056 13.3 3.0 1.2 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein YlqD PF11068.8 KOO21845.1 - 0.047 14.1 3.4 0.065 13.6 3.4 1.2 1 0 0 1 1 1 0 YlqD protein Complex1_LYR_2 PF13233.6 KOO21845.1 - 0.056 14.2 1.2 0.081 13.7 1.0 1.5 1 1 0 1 1 1 0 Complex1_LYR-like Fmp27_WPPW PF10359.9 KOO21845.1 - 0.28 10.0 4.0 0.27 10.1 4.0 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain SlyX PF04102.12 KOO21845.1 - 0.3 11.8 7.1 1.1 9.9 1.8 2.4 1 1 1 2 2 2 0 SlyX VSG_B PF13206.6 KOO21845.1 - 1.7 7.8 8.6 3.8 6.7 8.6 1.5 1 1 0 1 1 1 0 Trypanosomal VSG domain DUF883 PF05957.13 KOO21845.1 - 2.4 8.8 10.8 1.8 9.2 4.3 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4407 PF14362.6 KOO21845.1 - 3 7.1 9.7 3.7 6.8 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HalX PF08663.10 KOO21845.1 - 3.8 7.9 10.0 1 9.7 2.6 2.5 2 1 1 3 3 3 0 HalX domain TPT PF03151.16 KOO21846.1 - 3e-08 33.4 18.7 4.7e-08 32.7 18.7 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family RimM PF01782.18 KOO21847.1 - 6e-15 55.2 0.1 1.2e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 RimM N-terminal domain DNA_pol_phi PF04931.13 KOO21847.1 - 0.041 12.0 10.6 0.059 11.5 10.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 KOO21847.1 - 3.1 6.8 13.4 6 5.9 13.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Arc PF03869.14 KOO21848.1 - 0.41 10.5 1.7 0.45 10.4 0.3 1.7 2 0 0 2 2 2 0 Arc-like DNA binding domain Symplekin_C PF12295.8 KOO21849.1 - 1.9e-45 155.3 0.3 1.9e-45 155.3 0.3 2.5 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 KOO21849.1 - 2.5e-14 53.5 0.0 4.9e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) HEAT PF02985.22 KOO21849.1 - 0.77 10.2 3.5 51 4.5 0.8 3.4 2 0 0 2 2 2 0 HEAT repeat Epimerase PF01370.21 KOO21850.1 - 1.9e-54 184.7 0.0 2.6e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO21850.1 - 4.4e-12 46.0 0.0 7.1e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 KOO21850.1 - 1.8e-07 30.6 0.5 1.5e-06 27.6 0.0 2.1 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 KOO21850.1 - 6.2e-06 25.5 0.0 9.5e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 KOO21850.1 - 0.00056 19.0 0.4 0.0058 15.7 0.4 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KOO21850.1 - 0.019 14.1 0.1 0.071 12.3 0.0 1.8 1 1 1 2 2 2 0 Male sterility protein EF-hand_1 PF00036.32 KOO21851.1 - 1.3e-18 65.1 6.1 4.6e-05 22.7 0.4 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO21851.1 - 7.9e-18 64.7 3.7 8.2e-11 42.2 0.6 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO21851.1 - 1.6e-13 49.4 5.0 0.011 15.6 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO21851.1 - 2.7e-11 43.1 4.8 0.00011 22.0 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO21851.1 - 2.2e-10 39.5 12.3 0.00011 21.5 0.1 4.2 5 0 0 5 5 5 3 EF hand Ion_trans PF00520.31 KOO21851.1 - 5e-06 25.9 11.0 8.6e-06 25.2 11.0 1.4 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.7 KOO21851.1 - 8.8e-06 26.2 0.0 0.00057 20.4 0.0 3.5 3 1 1 4 4 3 2 Ankyrin repeats (3 copies) EF-hand_4 PF12763.7 KOO21851.1 - 1.9e-05 24.6 3.4 0.012 15.5 0.4 3.7 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO21851.1 - 4e-05 23.9 0.5 0.00012 22.3 0.2 2.1 2 0 0 2 2 1 1 EF-hand domain Ank_4 PF13637.6 KOO21851.1 - 0.0017 18.9 0.0 7.3 7.3 0.1 4.4 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Dockerin_1 PF00404.18 KOO21851.1 - 0.0023 18.1 2.3 0.077 13.2 1.5 2.7 2 1 0 2 2 2 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KOO21851.1 - 0.03 14.6 0.4 17 5.8 0.3 3.4 3 2 1 4 4 3 0 Secreted protein acidic and rich in cysteine Ca binding region Metallophos PF00149.28 KOO21852.1 - 1.1e-16 62.0 1.0 3.5e-16 60.3 0.2 2.1 3 0 0 3 3 3 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 KOO21852.1 - 5.1e-15 55.8 0.0 1.2e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 KOO21852.1 - 1.9e-09 38.2 0.1 5.7e-09 36.7 0.1 1.8 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 KOO21852.1 - 0.0015 18.8 0.0 0.0062 16.7 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain adh_short PF00106.25 KOO21853.1 - 2.6e-49 167.4 1.2 3.7e-49 166.9 1.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO21853.1 - 7.3e-34 117.3 3.5 9.8e-34 116.9 3.5 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO21853.1 - 1.2e-09 38.4 0.5 1.6e-09 37.9 0.5 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 KOO21853.1 - 0.021 14.1 0.4 0.33 10.2 0.0 2.7 2 1 1 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 KOO21853.1 - 0.065 12.7 0.1 0.12 11.8 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family UAA PF08449.11 KOO21854.1 - 1.7e-56 191.6 23.8 2.4e-56 191.1 23.8 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO21854.1 - 0.0083 16.3 16.8 0.0083 16.3 16.8 3.1 3 1 0 3 3 3 2 EamA-like transporter family Ndr PF03096.14 KOO21854.1 - 0.013 14.2 0.5 0.022 13.5 0.5 1.4 1 0 0 1 1 1 0 Ndr family TPT PF03151.16 KOO21854.1 - 0.037 13.4 16.7 0.09 12.1 16.6 1.7 1 1 0 1 1 1 0 Triose-phosphate Transporter family XPG_N PF00752.17 KOO21855.1 - 7.8e-29 100.1 0.0 1.4e-28 99.3 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KOO21855.1 - 5.7e-28 97.1 0.1 1.2e-27 96.1 0.1 1.6 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 KOO21855.1 - 0.0039 17.8 0.0 0.0089 16.6 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.16 KOO21855.1 - 0.013 15.4 0.0 0.052 13.5 0.0 1.8 1 1 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain HHH_2 PF12826.7 KOO21855.1 - 0.058 13.5 0.1 0.19 11.8 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_5 PF14520.6 KOO21855.1 - 0.07 13.7 1.2 0.56 10.9 0.1 2.8 3 0 0 3 3 3 0 Helix-hairpin-helix domain NAD_binding_10 PF13460.6 KOO21856.1 - 1e-26 94.0 0.0 1.4e-26 93.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOO21856.1 - 5.3e-05 22.8 0.1 0.00014 21.4 0.1 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO21856.1 - 0.00018 20.6 0.0 0.00025 20.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 KOO21856.1 - 0.0002 21.0 0.1 0.00049 19.7 0.1 1.6 2 0 0 2 2 2 1 NmrA-like family DapB_N PF01113.20 KOO21856.1 - 0.00076 19.6 0.1 0.0044 17.1 0.1 2.1 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 KOO21856.1 - 0.0023 18.2 0.1 0.0041 17.4 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 KOO21856.1 - 0.0055 15.9 0.0 0.16 11.2 0.1 2.2 2 0 0 2 2 2 1 Male sterility protein TrkA_C PF02080.21 KOO21856.1 - 0.014 15.2 0.0 0.035 13.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-C domain adh_short PF00106.25 KOO21856.1 - 0.14 11.6 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 short chain dehydrogenase TPR_10 PF13374.6 KOO21858.1 - 7e-68 222.8 33.1 7.8e-11 41.5 0.3 9.0 7 1 1 8 8 8 8 Tetratricopeptide repeat TPR_12 PF13424.6 KOO21858.1 - 8.8e-61 202.2 42.6 9e-16 57.9 3.6 7.4 3 1 5 8 8 7 6 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO21858.1 - 2.1e-21 76.7 19.9 4.6e-10 39.4 5.0 3.9 1 1 2 3 3 3 3 MalT-like TPR region TPR_1 PF00515.28 KOO21858.1 - 1.1e-13 50.3 15.2 0.019 14.8 0.1 7.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO21858.1 - 3.1e-13 48.7 22.8 0.19 11.9 0.2 8.9 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOO21858.1 - 1.1e-12 47.0 12.1 0.87 10.0 0.1 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat 4HBT_2 PF13279.6 KOO21858.1 - 3.6e-10 40.4 0.0 7.6e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Thioesterase-like superfamily TPR_4 PF07721.14 KOO21858.1 - 6.4e-08 32.5 57.1 0.023 15.3 0.3 11.5 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO21858.1 - 2.6e-07 30.2 33.2 0.61 10.3 0.2 8.1 9 0 0 9 9 7 5 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO21858.1 - 4.6e-07 30.0 4.7 5.4 7.4 0.0 6.3 6 0 0 6 6 6 2 Osmosensory transporter coiled coil TPR_19 PF14559.6 KOO21858.1 - 6.2e-06 26.6 31.5 0.07 13.6 0.9 6.5 4 1 3 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 KOO21858.1 - 1.6e-05 25.5 49.4 0.0044 17.6 2.2 9.0 4 2 4 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO21858.1 - 4.1e-05 23.2 17.5 1.1 9.0 0.2 7.6 7 1 1 8 8 8 2 TPR repeat TPR_17 PF13431.6 KOO21858.1 - 5.7e-05 23.2 10.7 8 7.1 0.0 7.2 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_3 PF07720.12 KOO21858.1 - 0.0011 18.9 0.0 93 3.2 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO21858.1 - 0.038 14.8 44.5 0.74 10.8 0.5 10.0 11 0 0 11 11 8 0 Tetratricopeptide repeat 4HBT PF03061.22 KOO21858.1 - 0.071 13.5 0.1 0.22 11.9 0.1 1.9 1 0 0 1 1 1 0 Thioesterase superfamily Acyl-ACP_TE PF01643.17 KOO21858.1 - 0.24 10.7 0.0 0.37 10.0 0.0 1.2 1 0 0 1 1 1 0 Acyl-ACP thioesterase TPR_21 PF09976.9 KOO21858.1 - 1 9.0 16.4 2.4 7.8 1.1 4.6 2 2 2 4 4 4 0 Tetratricopeptide repeat-like domain Asp PF00026.23 KOO21860.1 - 1e-79 268.2 0.0 1.2e-79 268.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO21860.1 - 2.2e-09 37.8 0.2 9.6e-06 25.9 0.0 2.2 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 KOO21860.1 - 3e-05 23.8 0.0 8.8e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal ABC_membrane_2 PF06472.15 KOO21861.1 - 0.00014 21.4 0.0 0.00022 20.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_membrane_2 PF06472.15 KOO21862.1 - 9e-46 156.4 2.1 1.2e-45 156.0 2.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 SbmA_BacA PF05992.12 KOO21862.1 - 4.9e-10 39.4 3.6 2.8e-09 36.9 3.6 1.9 1 1 0 1 1 1 1 SbmA/BacA-like family ABC_tran PF00005.27 KOO21862.1 - 1.1e-07 32.5 0.0 2e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.18 KOO21862.1 - 0.00079 18.9 0.2 0.012 15.0 0.1 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_29 PF13555.6 KOO21862.1 - 0.001 18.7 0.1 0.0023 17.6 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 KOO21862.1 - 0.0026 18.1 0.0 0.009 16.4 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 KOO21862.1 - 0.012 14.8 0.1 0.021 14.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 KOO21862.1 - 0.021 14.2 0.1 0.037 13.4 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 KOO21862.1 - 0.024 14.5 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 KOO21862.1 - 0.027 14.2 0.0 0.057 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain NeA_P2 PF12312.8 KOO21862.1 - 0.06 12.8 0.1 0.11 11.9 0.1 1.5 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein AAA_7 PF12775.7 KOO21862.1 - 0.061 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 KOO21862.1 - 0.099 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KOO21862.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain MCM PF00493.23 KOO21862.1 - 0.17 11.0 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain Rubredoxin PF00301.20 KOO21863.1 - 3.1e-05 23.9 7.3 0.0014 18.7 7.3 2.3 1 1 0 1 1 1 1 Rubredoxin Zn_ribbon_SprT PF17283.2 KOO21863.1 - 0.00033 20.5 1.1 0.001 18.9 1.1 1.8 1 1 0 1 1 1 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 KOO21863.1 - 0.0092 16.1 1.9 0.015 15.4 0.6 2.0 2 0 0 2 2 2 1 Zinc ribbon domain HypA PF01155.19 KOO21863.1 - 0.014 15.4 0.4 0.024 14.6 0.5 1.6 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rubredoxin_2 PF18073.1 KOO21863.1 - 0.077 12.7 7.3 0.96 9.2 0.5 2.8 3 0 0 3 3 3 0 Rubredoxin metal binding domain PhnA_Zn_Ribbon PF08274.12 KOO21863.1 - 0.27 11.2 2.7 20 5.2 0.2 2.9 3 0 0 3 3 3 0 PhnA Zinc-Ribbon Zn_Tnp_IS1595 PF12760.7 KOO21863.1 - 0.36 10.8 4.9 0.93 9.5 4.5 1.9 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_10 PF10058.9 KOO21863.1 - 0.54 10.0 3.3 13 5.7 0.1 3.0 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein TF_Zn_Ribbon PF08271.12 KOO21863.1 - 0.66 9.5 4.2 0.87 9.2 0.0 2.4 3 0 0 3 3 3 0 TFIIB zinc-binding UPF0547 PF10571.9 KOO21863.1 - 1.2 9.3 7.4 2.3 8.4 0.3 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Nudix_N_2 PF14803.6 KOO21863.1 - 2.6 8.0 7.3 10 6.1 0.2 2.8 3 0 0 3 3 3 0 Nudix N-terminal zf-RanBP PF00641.18 KOO21863.1 - 2.7 7.4 8.4 12 5.3 0.3 3.1 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others Hamartin PF04388.12 KOO21865.1 - 0.072 11.8 18.4 0.094 11.4 18.4 1.1 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 KOO21865.1 - 1.1 9.1 18.9 1.5 8.8 18.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GSIII_N PF12437.8 KOO21867.1 - 9.7e-48 161.8 0.0 6.4e-47 159.2 0.0 2.2 2 0 0 2 2 2 1 Glutamine synthetase type III N terminal Gln-synt_C-ter PF18318.1 KOO21867.1 - 4.3e-32 110.4 0.2 7.8e-32 109.6 0.2 1.4 1 0 0 1 1 1 1 Glutamine synthetase C-terminal domain Gln-synt_C PF00120.24 KOO21867.1 - 4e-17 62.2 0.0 1.6e-16 60.2 0.0 1.9 2 0 0 2 2 2 1 Glutamine synthetase, catalytic domain Mg_trans_NIPA PF05653.14 KOO21868.1 - 1.9e-22 79.7 10.7 3.3e-22 79.0 10.7 1.3 1 0 0 1 1 1 1 Magnesium transporter NIPA TMEM234 PF10639.9 KOO21868.1 - 0.0036 17.3 4.2 0.77 9.8 0.5 2.4 2 0 0 2 2 2 2 Putative transmembrane family 234 AgrB PF04647.15 KOO21868.1 - 0.19 11.0 4.1 3.4 6.9 2.0 2.6 2 1 0 2 2 2 0 Accessory gene regulator B Multi_Drug_Res PF00893.19 KOO21868.1 - 4.6 8.0 15.2 0.13 13.0 1.5 2.9 3 1 0 3 3 3 0 Small Multidrug Resistance protein Pkinase PF00069.25 KOO21869.1 - 1.5e-62 211.4 0.0 1.7e-62 211.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21869.1 - 5.5e-26 91.4 0.0 1.1e-25 90.4 0.0 1.5 1 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 KOO21869.1 - 0.0018 17.7 0.4 0.003 16.9 0.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO21869.1 - 0.002 18.1 0.6 0.0052 16.7 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family MWFE PF15879.5 KOO21870.1 - 1.8e-10 40.8 0.0 2e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit DSPc PF00782.20 KOO21871.1 - 1.5e-28 99.2 0.0 2e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOO21871.1 - 0.0012 18.5 0.1 0.0024 17.5 0.1 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase G-alpha PF00503.20 KOO21872.1 - 2.7e-95 319.5 0.5 4.1e-95 319.0 0.5 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KOO21872.1 - 1.3e-14 54.0 3.0 1.1e-11 44.5 0.2 3.1 2 1 1 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOO21872.1 - 9.9e-05 21.8 2.1 0.0051 16.2 0.3 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 KOO21872.1 - 0.014 15.6 0.3 6.3 7.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DAP3 PF10236.9 KOO21872.1 - 0.1 11.7 0.1 0.19 10.8 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_29 PF13555.6 KOO21872.1 - 0.17 11.7 0.0 0.54 10.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Glyco_transf_64 PF09258.10 KOO21873.1 - 9.1e-05 21.9 0.0 0.00012 21.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain RRM_1 PF00076.22 KOO21874.1 - 1.8e-20 72.5 0.1 3.2e-11 42.9 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOO21874.1 - 1.9e-08 34.3 0.0 0.0022 18.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif Arm PF00514.23 KOO21875.1 - 3.8e-07 29.9 3.2 0.22 11.6 0.2 4.4 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KOO21875.1 - 0.021 14.9 0.2 1.5 8.9 0.0 3.0 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Cas_Cas1 PF01867.16 KOO21876.1 - 4.7 6.3 12.4 1.1 8.4 2.6 2.1 2 0 0 2 2 2 0 CRISPR associated protein Cas1 SAP PF02037.27 KOO21877.1 - 0.0034 17.1 1.3 0.0087 15.8 1.3 1.7 1 0 0 1 1 1 1 SAP domain TPT PF03151.16 KOO21878.1 - 8.9e-09 35.1 9.6 1.2e-08 34.7 9.6 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family Arm PF00514.23 KOO21879.1 - 3.1e-117 379.5 155.3 2e-07 30.8 0.4 42.1 41 2 2 43 43 43 31 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO21879.1 - 5.1e-11 42.5 0.0 2.6 8.1 0.0 10.9 13 1 0 13 13 13 2 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO21879.1 - 6.6e-08 32.3 4.2 1.3 8.5 0.0 9.0 10 1 1 11 11 11 2 Armadillo-like DUF5578 PF17741.1 KOO21879.1 - 1.8e-06 27.6 12.8 0.15 11.5 0.0 7.8 8 1 0 8 8 8 2 Family of unknown function (DUF5578) Cnd1 PF12717.7 KOO21879.1 - 3.7e-05 23.8 0.2 23 5.0 0.0 6.3 7 1 0 7 7 7 0 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 KOO21879.1 - 0.00023 20.6 0.0 10 5.3 0.0 5.7 4 2 1 5 5 5 1 V-ATPase subunit H RICTOR_N PF14664.6 KOO21879.1 - 0.0007 18.7 5.8 1.8 7.5 0.0 7.5 9 1 1 10 10 10 1 Rapamycin-insensitive companion of mTOR, N-term V-ATPase_H_C PF11698.8 KOO21879.1 - 0.002 18.2 0.0 5 7.3 0.0 4.8 6 0 0 6 6 6 1 V-ATPase subunit H TPT PF03151.16 KOO21880.1 - 2.7e-08 33.5 0.8 3.1e-08 33.3 0.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO21880.1 - 0.002 18.3 5.3 0.0023 18.1 5.3 1.1 1 0 0 1 1 1 1 EamA-like transporter family PUNUT PF16913.5 KOO21880.1 - 0.003 16.8 2.8 0.0036 16.6 2.8 1.1 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport DUF5516 PF17637.2 KOO21880.1 - 0.093 12.5 5.1 0.11 12.2 0.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5516) GNVR PF13807.6 KOO21880.1 - 0.12 12.4 0.8 0.17 11.8 0.1 1.7 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase DUF1726 PF08351.11 KOO21880.1 - 0.3 11.1 2.3 3.7 7.6 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1726) Arm PF00514.23 KOO21881.1 - 7.1e-50 165.6 55.5 2e-05 24.5 0.1 16.1 15 1 0 15 15 15 11 Armadillo/beta-catenin-like repeat DUF5578 PF17741.1 KOO21881.1 - 4.1e-07 29.7 5.9 1.2 8.6 0.1 4.8 3 2 0 4 4 4 4 Family of unknown function (DUF5578) V-ATPase_H_N PF03224.14 KOO21881.1 - 3e-05 23.5 0.0 0.016 14.5 0.0 3.5 2 1 0 2 2 2 1 V-ATPase subunit H Atx10homo_assoc PF09759.9 KOO21881.1 - 4.9e-05 23.3 0.1 0.51 10.4 0.0 3.8 5 0 0 5 5 5 2 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO21881.1 - 0.006 16.1 0.0 3.1 7.2 0.0 4.2 3 1 1 4 4 4 1 Armadillo-like Cnd1 PF12717.7 KOO21881.1 - 0.014 15.5 0.0 1.1 9.3 0.0 3.5 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOO21881.1 - 0.18 12.2 31.2 0.4 11.1 0.0 8.8 8 0 0 8 8 8 0 HEAT repeat TOBE_3 PF12857.7 KOO21882.1 - 0.00099 19.0 0.0 0.0028 17.5 0.0 1.8 2 0 0 2 2 2 1 TOBE-like domain CDC48_N PF02359.18 KOO21882.1 - 0.023 14.8 0.0 0.57 10.4 0.0 2.1 1 1 1 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain Response_reg PF00072.24 KOO21883.1 - 0.033 14.4 0.0 0.12 12.5 0.0 2.0 1 0 0 1 1 1 0 Response regulator receiver domain CortBP2 PF09727.9 KOO21883.1 - 0.1 12.5 43.3 0.3 11.0 6.5 4.2 2 2 2 4 4 4 0 Cortactin-binding protein-2 Cytochrom_D1 PF02239.16 KOO21883.1 - 0.48 8.9 4.6 4.5 5.7 0.1 3.0 3 0 0 3 3 3 0 Cytochrome D1 heme domain DUF5611 PF18446.1 KOO21883.1 - 2.3 9.1 25.8 18 6.2 1.0 5.2 2 2 2 4 4 4 0 Domain of unknown function (DUF5611) Csd3_N PF18059.1 KOO21883.1 - 7 7.3 7.2 96 3.6 0.1 4.6 3 1 1 4 4 4 0 Csd3 N-terminal LRR_6 PF13516.6 KOO21884.1 - 6.6e-19 66.3 81.9 3.7e-05 23.5 0.7 24.0 25 0 0 25 25 25 5 Leucine Rich repeat LRR_4 PF12799.7 KOO21884.1 - 5.9e-17 61.5 70.2 6.4e-05 23.2 2.4 14.7 9 3 8 17 17 17 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO21884.1 - 1.1e-13 50.7 63.5 0.00015 21.5 2.0 13.2 12 3 3 15 15 15 6 Leucine rich repeat NACHT PF05729.12 KOO21884.1 - 1e-07 32.1 0.4 0.0014 18.6 0.1 3.3 3 0 0 3 3 3 2 NACHT domain AAA_19 PF13245.6 KOO21884.1 - 7e-06 26.4 0.0 0.017 15.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 KOO21884.1 - 7.4e-05 23.2 0.0 0.0048 17.3 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.21 KOO21884.1 - 0.075 12.5 0.0 3.3 7.1 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Pheromone PF08015.11 KOO21884.1 - 0.2 12.7 0.7 4.8 8.3 0.5 3.7 2 0 0 2 2 2 0 Fungal mating-type pheromone LRR_1 PF00560.33 KOO21884.1 - 2.7 8.9 46.4 48 5.1 0.1 17.0 19 1 0 19 19 19 0 Leucine Rich Repeat LRR_9 PF14580.6 KOO21884.1 - 5.5 6.5 8.8 14 5.1 0.2 3.4 2 1 1 3 3 3 0 Leucine-rich repeat HC2 PF07382.11 KOO21885.1 - 0.029 14.5 20.2 0.066 13.3 20.2 1.6 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 uDENN PF03456.18 KOO21886.1 - 4.1e-05 24.3 0.0 6.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 uDENN domain DENN PF02141.21 KOO21886.1 - 0.0001 22.3 0.0 0.00016 21.7 0.0 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain Glyco_transf_4 PF13439.6 KOO21887.1 - 4.4e-32 111.4 3.6 9.2e-32 110.4 3.6 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 PIGA PF08288.12 KOO21887.1 - 1.8e-28 98.9 0.2 4.1e-28 97.8 0.2 1.6 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_trans_4_4 PF13579.6 KOO21887.1 - 2.6e-22 80.0 6.7 2.6e-22 80.0 6.7 2.3 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 KOO21887.1 - 4.4e-22 78.4 0.0 6.6e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOO21887.1 - 1.5e-19 70.7 0.2 4.3e-19 69.3 0.2 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 KOO21887.1 - 0.0012 18.5 0.1 0.065 12.9 0.0 2.2 2 0 0 2 2 2 1 Starch synthase catalytic domain Glyco_trans_4_2 PF13477.6 KOO21887.1 - 0.0047 17.0 0.0 0.0083 16.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like PTS_2-RNA PF01885.16 KOO21888.1 - 3.5e-50 170.6 0.1 6.6e-50 169.7 0.1 1.5 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family APH PF01636.23 KOO21888.1 - 8.2e-05 22.6 0.3 8.2e-05 22.6 0.3 3.5 4 1 0 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.14 KOO21888.1 - 0.00023 20.6 0.0 0.00072 19.0 0.0 1.8 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOO21888.1 - 0.02 14.5 0.0 0.044 13.3 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF5117 PF17148.4 KOO21888.1 - 0.17 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5117) Arm PF00514.23 KOO21889.1 - 0.012 15.7 0.0 2 8.6 0.0 2.4 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat DUF4355 PF14265.6 KOO21889.1 - 0.014 15.7 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) DUF615 PF04751.14 KOO21889.1 - 0.046 13.7 0.2 0.08 12.9 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF615) MFS_1 PF07690.16 KOO21890.1 - 7.4e-43 146.8 44.9 8.7e-36 123.6 20.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOO21890.1 - 4.6e-06 25.7 6.1 0.01 14.7 6.9 2.8 1 1 1 2 2 2 2 MFS_1 like family MFS_3 PF05977.13 KOO21890.1 - 0.00028 19.4 4.5 0.00028 19.4 4.5 1.7 2 0 0 2 2 2 1 Transmembrane secretion effector Uso1_p115_head PF04869.14 KOO21891.1 - 0.00018 20.8 0.0 0.00034 19.9 0.0 1.3 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Shugoshin_N PF07558.11 KOO21891.1 - 0.032 14.1 5.2 3.1 7.8 0.2 3.6 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region CENP-F_leu_zip PF10473.9 KOO21891.1 - 0.3 11.1 29.5 0.029 14.4 5.4 4.1 3 2 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 KOO21891.1 - 0.83 8.2 17.1 0.68 8.5 0.9 3.4 2 1 0 3 3 3 0 AAA domain KASH_CCD PF14662.6 KOO21891.1 - 1.7 8.4 28.9 0.37 10.6 8.4 3.2 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH CCDC92 PF14916.6 KOO21891.1 - 2 8.3 4.3 7.5 6.4 0.1 3.2 4 0 0 4 4 4 0 Coiled-coil domain of unknown function FH2 PF02181.23 KOO21891.1 - 2.9 6.9 8.9 0.34 10.0 0.2 2.8 2 1 1 3 3 3 0 Formin Homology 2 Domain Tup_N PF08581.10 KOO21891.1 - 3 8.2 8.3 3.4 8.0 0.1 3.8 4 1 0 4 4 4 0 Tup N-terminal PI3K_P85_iSH2 PF16454.5 KOO21891.1 - 3 7.4 11.8 0.73 9.4 0.1 3.3 4 0 0 4 4 4 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4407 PF14362.6 KOO21891.1 - 3.2 7.0 48.5 0.89 8.8 16.4 3.3 1 1 1 3 3 3 0 Domain of unknown function (DUF4407) Lectin_N PF03954.14 KOO21891.1 - 3.2 7.5 7.2 7 6.4 0.7 3.6 3 1 0 3 3 3 0 Hepatic lectin, N-terminal domain Fez1 PF06818.15 KOO21891.1 - 3.8 7.9 26.5 15 6.0 4.0 3.2 2 1 0 2 2 2 0 Fez1 Fmp27_WPPW PF10359.9 KOO21891.1 - 7.8 5.2 6.6 1.4 7.7 0.4 2.3 2 1 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain FlxA PF14282.6 KOO21891.1 - 8 6.5 17.1 0.79 9.7 4.2 4.0 3 1 1 4 4 4 0 FlxA-like protein Rho_Binding PF08912.11 KOO21891.1 - 8.6 7.3 14.4 9.9 7.1 0.7 4.6 4 1 2 6 6 6 0 Rho Binding S6PP PF05116.13 KOO21892.1 - 2.3e-06 27.3 0.0 8.2e-06 25.5 0.0 1.9 2 1 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 KOO21892.1 - 4.9e-06 26.5 0.0 0.12 12.1 0.0 3.6 4 0 0 4 4 4 2 haloacid dehalogenase-like hydrolase Glycos_transf_1 PF00534.20 KOO21893.1 - 7.5e-24 84.2 0.0 9.5e-24 83.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOO21893.1 - 7.8e-16 58.7 0.0 1.2e-15 58.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Ubiquitin_3 PF14836.6 KOO21893.1 - 0.15 12.0 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Ank_5 PF13857.6 KOO21894.1 - 2.5e-21 75.4 1.7 4.1e-10 39.7 0.1 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO21894.1 - 1.2e-20 71.4 1.2 1.3e-06 28.3 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO21894.1 - 2.5e-20 72.0 1.8 6.9e-06 26.3 0.0 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_2 PF12796.7 KOO21894.1 - 3.2e-18 66.1 0.0 1.5e-10 41.5 0.0 2.6 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO21894.1 - 2.3e-15 56.7 0.5 6.1e-08 33.1 0.0 3.3 3 1 0 3 3 3 2 Ankyrin repeats (many copies) MORN PF02493.20 KOO21895.1 - 1.4e-77 251.2 65.1 3.3e-10 39.3 3.6 14.4 15 0 0 15 15 15 13 MORN repeat DEC-1_N PF04625.13 KOO21895.1 - 0.22 10.5 6.7 0.29 10.1 6.7 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Glyco_transf_29 PF00777.18 KOO21896.1 - 1e-34 120.2 0.0 1.6e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) GHMP_kinases_N PF00288.26 KOO21897.1 - 8e-09 35.6 10.0 8e-09 35.6 10.0 3.8 3 1 0 3 3 3 1 GHMP kinases N terminal domain GalKase_gal_bdg PF10509.9 KOO21897.1 - 0.09 12.3 0.1 0.19 11.3 0.1 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature WD40 PF00400.32 KOO21898.1 - 1.7e-30 104.6 19.5 2.1e-07 31.5 0.1 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO21898.1 - 4.5e-07 30.1 0.4 3.8 7.9 0.0 4.9 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO21898.1 - 4.8e-05 22.5 0.4 0.15 11.0 0.0 3.7 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KOO21898.1 - 1.1 7.8 4.4 1.6 7.3 0.4 2.9 2 1 2 4 4 4 0 Nucleoporin Nup120/160 Aminotran_1_2 PF00155.21 KOO21900.1 - 4e-52 177.6 0.0 4.6e-52 177.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KOO21900.1 - 0.00093 18.6 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_MocR PF12897.7 KOO21900.1 - 0.015 14.1 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase Elong-fact-P_C PF09285.11 KOO21901.1 - 0.0034 17.1 0.0 0.0082 15.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P, C-terminal NPCBM_assoc PF10633.9 KOO21901.1 - 0.024 14.9 0.6 6.2 7.2 0.2 2.2 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Endotoxin_C PF03944.14 KOO21901.1 - 0.2 12.0 0.0 0.22 11.8 0.0 1.1 1 0 0 1 1 1 0 delta endotoxin DnaJ PF00226.31 KOO21902.1 - 4e-12 46.1 0.0 1.9e-11 43.9 0.0 2.3 1 0 0 1 1 1 1 DnaJ domain DUF5558 PF17713.1 KOO21902.1 - 0.4 11.1 4.0 1.1 9.7 4.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5558) PRIMA1 PF16101.5 KOO21902.1 - 8.4 6.5 11.3 0.28 11.2 4.2 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DNA_topoisoIV PF00521.20 KOO21903.1 - 5.5e-123 411.0 0.1 1.1e-122 410.1 0.0 1.5 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KOO21903.1 - 3.6e-46 156.6 0.1 1e-45 155.2 0.1 1.8 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 KOO21903.1 - 7.1e-22 77.7 0.1 1.8e-21 76.4 0.1 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 KOO21903.1 - 3.3e-11 43.7 0.0 6.9e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 KOO21903.1 - 1.8e-07 31.3 0.0 5e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 Toprim domain Actin PF00022.19 KOO21904.1 - 6e-09 35.0 0.0 6.4e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Actin Pkinase PF00069.25 KOO21905.1 - 1.1e-39 136.5 0.0 1.5e-39 135.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO21905.1 - 1.7e-12 47.2 0.0 2.6e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 KOO21905.1 - 0.00017 21.2 0.0 0.00028 20.5 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 KOO21905.1 - 0.00019 21.5 0.0 0.00066 19.7 0.0 1.9 1 0 0 1 1 1 1 Phosphotransferase enzyme family Actin PF00022.19 KOO21905.1 - 0.00083 18.1 0.2 0.21 10.1 0.1 2.2 2 0 0 2 2 2 2 Actin UN_NPL4 PF11543.8 KOO21905.1 - 0.0015 19.0 0.0 0.0027 18.1 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 NPL4 PF05021.15 KOO21905.1 - 0.0036 16.7 0.0 0.0053 16.2 0.0 1.2 1 0 0 1 1 1 1 NPL4 family Kdo PF06293.14 KOO21905.1 - 0.015 14.7 0.0 0.032 13.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOO21905.1 - 0.19 11.3 0.1 1.3 8.6 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Myosin_head PF00063.21 KOO21906.1 - 1e-205 685.0 0.2 6.9e-205 682.2 0.2 1.9 1 1 0 1 1 1 1 Myosin head (motor domain) PH PF00169.29 KOO21906.1 - 4.4e-73 242.5 13.9 1.7e-16 60.6 0.0 8.4 8 0 0 8 8 8 6 PH domain PH_8 PF15409.6 KOO21906.1 - 7.2e-21 74.3 16.2 0.00016 21.9 0.1 7.4 7 0 0 7 7 6 5 Pleckstrin homology domain PH_3 PF14593.6 KOO21906.1 - 1.4e-19 70.1 0.0 0.0033 17.5 0.0 6.4 5 1 1 6 6 6 4 PH domain PH_11 PF15413.6 KOO21906.1 - 1.3e-13 51.2 19.8 0.0014 19.0 0.7 8.2 7 1 0 7 7 7 4 Pleckstrin homology domain PDZ_6 PF17820.1 KOO21906.1 - 2.6e-07 30.4 0.1 7.1e-07 29.0 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO21906.1 - 1.3e-06 28.7 0.0 2.7e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PH_2 PF08458.10 KOO21906.1 - 9.2e-06 26.0 0.8 0.6 10.5 0.1 6.1 6 0 0 6 6 6 1 Plant pleckstrin homology-like region PH_6 PF15406.6 KOO21906.1 - 4.5e-05 23.7 0.1 0.22 11.8 0.0 4.4 4 0 0 4 4 4 1 Pleckstrin homology domain PDZ_2 PF13180.6 KOO21906.1 - 0.0012 19.2 0.0 0.0027 18.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PH_13 PF16652.5 KOO21906.1 - 0.0042 16.9 5.2 0.95 9.3 0.1 5.2 5 0 0 5 5 5 1 Pleckstrin homology domain AAA_22 PF13401.6 KOO21906.1 - 0.14 12.4 0.0 0.5 10.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain SopD PF11047.8 KOO21908.1 - 0.085 12.0 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Salmonella outer protein D COesterase PF00135.28 KOO21909.1 - 1.7e-67 228.4 0.0 2.5e-67 227.9 0.0 1.2 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KOO21909.1 - 8.3e-06 25.8 1.4 0.00022 21.2 0.0 3.0 3 0 0 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOO21909.1 - 0.027 14.0 0.0 0.066 12.7 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family HC2 PF07382.11 KOO21910.1 - 0.011 15.8 15.8 0.011 15.8 15.8 2.7 2 0 0 2 2 2 0 Histone H1-like nucleoprotein HC2 Glyco_transf_34 PF05637.12 KOO21910.1 - 0.042 13.6 0.1 0.086 12.6 0.1 1.4 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family DUF3139 PF11337.8 KOO21910.1 - 0.07 13.8 0.3 0.23 12.1 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) DUF2196 PF09962.9 KOO21910.1 - 0.14 12.1 0.1 0.47 10.5 0.1 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2196) TPR_MLP1_2 PF07926.12 KOO21911.1 - 0.0029 17.7 14.3 0.0029 17.7 14.3 5.7 1 1 3 4 4 4 1 TPR/MLP1/MLP2-like protein Ycf54 PF10674.9 KOO21911.1 - 0.35 11.2 4.4 0.21 11.9 1.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2488) DUF775 PF05603.12 KOO21911.1 - 0.51 9.9 6.0 0.1 12.1 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) FlaC_arch PF05377.11 KOO21911.1 - 1.6 9.2 7.6 17 5.9 0.3 4.6 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) Filament PF00038.21 KOO21911.1 - 2.1 7.8 54.0 12 5.4 0.7 4.3 2 1 0 2 2 2 0 Intermediate filament protein PP2C_2 PF13672.6 KOO21912.1 - 0.28 10.8 2.4 0.34 10.5 2.4 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C GMC_oxred_C PF05199.13 KOO21913.1 - 4.2e-32 111.6 0.0 5.7e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase WD40 PF00400.32 KOO21915.1 - 1.3e-13 51.2 0.2 0.058 14.3 0.0 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO21915.1 - 5.3e-05 23.4 0.0 0.79 10.1 0.0 4.7 4 1 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 KOO21915.1 - 0.012 14.9 0.1 0.4 9.9 0.0 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus LRR_6 PF13516.6 KOO21916.1 - 2.6e-16 58.2 19.1 0.00036 20.3 0.1 6.4 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 KOO21916.1 - 9.6e-07 29.0 2.1 0.012 16.0 0.3 3.4 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) WD40 PF00400.32 KOO21917.1 - 1.1e-34 117.8 10.9 6e-09 36.4 0.4 5.2 4 0 0 4 4 4 4 WD domain, G-beta repeat DUF3431 PF11913.8 KOO21917.1 - 4.7e-14 52.7 0.0 5.8e-08 32.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3431) Ge1_WD40 PF16529.5 KOO21917.1 - 8.8e-09 34.8 1.0 0.14 11.1 0.0 3.4 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO21917.1 - 1.5e-08 34.8 0.3 0.068 13.5 0.0 4.6 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO21917.1 - 2.3e-07 30.5 0.1 0.93 9.5 0.0 3.9 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 KOO21917.1 - 0.0001 21.8 0.6 0.93 8.8 0.1 3.0 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 KOO21917.1 - 0.0056 15.0 0.0 0.23 9.7 0.0 2.3 1 1 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz DCX PF03607.17 KOO21917.1 - 0.016 15.3 0.0 16 5.7 0.0 4.0 4 0 0 4 4 4 0 Doublecortin Kelch_4 PF13418.6 KOO21918.1 - 0.00013 21.9 23.5 0.016 15.2 0.3 6.4 6 1 1 7 7 7 3 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO21918.1 - 0.0025 18.0 3.2 5.2 7.5 0.0 5.0 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 KOO21918.1 - 0.021 15.1 23.4 0.83 10.0 0.1 5.8 6 1 0 6 6 6 0 Galactose oxidase, central domain V_ATPase_I PF01496.19 KOO21920.1 - 6.3e-245 814.9 0.0 1.8e-244 813.4 0.0 1.7 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family PhyH PF05721.13 KOO21921.1 - 2.4e-12 47.6 0.1 3.5e-11 43.8 0.1 2.1 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 KOO21921.1 - 0.1 11.3 0.0 3.4 6.3 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1479) PP2C PF00481.21 KOO21923.1 - 7.3e-72 242.1 0.1 5.1e-59 200.0 0.1 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 KOO21923.1 - 7.5e-05 22.5 1.0 0.0026 17.4 0.1 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C MMR_HSR1 PF01926.23 KOO21924.1 - 8.3e-17 61.3 0.0 1.5e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOO21924.1 - 0.0033 17.0 0.0 0.0069 15.9 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KOO21924.1 - 0.0049 16.8 0.0 0.016 15.1 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 KOO21924.1 - 0.014 15.5 0.0 0.044 13.8 0.1 1.8 2 0 0 2 2 2 0 Dynamin family AIG1 PF04548.16 KOO21924.1 - 0.016 14.6 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Roc PF08477.13 KOO21924.1 - 0.092 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase MFS_1 PF07690.16 KOO21925.1 - 0.0018 17.3 10.0 0.0039 16.2 10.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 KOO21925.1 - 0.006 15.9 5.3 0.0075 15.6 5.3 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB EcsB PF05975.12 KOO21925.1 - 0.02 13.7 4.3 0.024 13.5 4.3 1.0 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB Phage_holin_3_6 PF07332.11 KOO21925.1 - 1.2 9.2 8.6 0.81 9.8 1.0 2.1 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DnaJ PF00226.31 KOO21926.1 - 2.3e-09 37.2 0.3 1.8e-08 34.3 0.1 2.5 2 0 0 2 2 2 1 DnaJ domain Cupin_2 PF07883.11 KOO21927.1 - 4.2e-05 23.2 0.0 5.4e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 KOO21927.1 - 0.0015 18.1 0.0 0.002 17.8 0.0 1.1 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 KOO21927.1 - 0.0058 16.3 0.0 0.0075 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) ARD PF03079.14 KOO21927.1 - 0.019 15.2 0.0 0.026 14.7 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family Cupin_6 PF12852.7 KOO21927.1 - 0.12 12.0 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Cupin Aminotran_4 PF01063.19 KOO21931.1 - 3.2e-30 105.7 0.0 4.1e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Bestrophin PF01062.21 KOO21932.1 - 2.7e-22 79.5 0.0 4.7e-22 78.7 0.0 1.2 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel CHASE8 PF17152.4 KOO21933.1 - 0.1 12.8 3.5 0.5 10.6 1.0 2.9 1 1 1 2 2 2 0 Periplasmic sensor domain PGK PF00162.19 KOO21935.1 - 6.5e-145 482.8 0.8 7.6e-145 482.6 0.8 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase VKOR PF07884.14 KOO21936.1 - 4.7e-21 75.2 9.5 6.2e-21 74.9 9.5 1.1 1 0 0 1 1 1 1 Vitamin K epoxide reductase family Chorismate_bind PF00425.18 KOO21937.1 - 2.9e-62 210.6 0.0 3.8e-62 210.2 0.0 1.1 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 KOO21937.1 - 1.3e-09 38.1 0.0 2.4e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 KOO21937.1 - 2.7e-08 34.1 0.0 1.1e-06 28.9 0.0 2.3 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 KOO21937.1 - 0.019 14.7 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase C26 XAP5 PF04921.14 KOO21938.1 - 2.5e-07 30.8 6.6 0.0013 18.6 0.1 2.5 2 1 0 2 2 2 2 XAP5, circadian clock regulator DUF4604 PF15377.6 KOO21938.1 - 0.032 14.7 7.3 0.032 14.7 7.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Metallophos PF00149.28 KOO21940.1 - 3e-16 60.6 0.3 4e-16 60.1 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GAT PF03127.14 KOO21942.1 - 0.04 14.2 11.8 5.9 7.3 0.1 4.6 4 0 0 4 4 4 0 GAT domain Orbi_VP2 PF00898.17 KOO21942.1 - 0.23 9.2 13.3 0.23 9.2 12.4 1.3 1 1 0 1 1 1 0 Orbivirus outer capsid protein VP2 U5_2-snRNA_bdg PF10597.9 KOO21942.1 - 0.24 11.5 1.0 3 7.9 0.2 2.4 2 0 0 2 2 2 0 U5-snRNA binding site 2 of PrP8 Metallophos PF00149.28 KOO21943.1 - 2.4e-08 34.7 0.0 3.6e-05 24.4 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO21943.1 - 0.069 13.3 0.0 0.65 10.2 0.0 2.1 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain Methyltransf_4 PF02390.17 KOO21944.1 - 4.5e-08 32.8 0.0 3.9e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_31 PF13847.6 KOO21944.1 - 5.1e-05 23.1 0.0 0.00022 21.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 KOO21944.1 - 0.00011 21.5 0.0 0.00018 20.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 KOO21944.1 - 0.00019 22.0 0.0 0.00034 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 KOO21944.1 - 0.00021 20.9 0.0 0.0005 19.7 0.0 1.7 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_11 PF08241.12 KOO21944.1 - 0.00066 20.3 0.1 0.0013 19.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOO21944.1 - 0.084 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 KOO21944.1 - 0.098 11.9 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase GidB PF02527.15 KOO21944.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G PCMT PF01135.19 KOO21944.1 - 0.18 11.5 0.0 0.41 10.4 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Peptidase_C1 PF00112.23 KOO21945.1 - 2.9e-42 145.2 14.5 4.7e-42 144.5 14.5 1.3 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KOO21945.1 - 0.00099 18.0 0.7 0.0015 17.4 0.7 1.3 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C70 PF12385.8 KOO21945.1 - 0.016 15.1 0.0 0.064 13.2 0.0 2.0 2 0 0 2 2 2 0 Papain-like cysteine protease AvrRpt2 Methyltransf_21 PF05050.12 KOO21947.1 - 5e-11 42.9 0.0 1.1e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase FkbM domain Neur_chan_memb PF02932.16 KOO21947.1 - 0.00038 20.6 0.9 0.00071 19.7 0.9 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KOO21947.1 - 0.027 13.9 0.1 3.2 7.1 0.0 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel ligand binding domain DUF1708 PF08101.11 KOO21947.1 - 0.056 12.6 0.0 0.092 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) Stealth_CR3 PF17102.5 KOO21948.1 - 1.2e-09 37.9 1.9 2.3e-09 37.0 1.9 1.4 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR2 PF11380.8 KOO21948.1 - 3.8e-08 33.5 0.0 7.7e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 Stealth_CR4 PF17103.5 KOO21948.1 - 0.12 12.3 0.0 0.33 10.9 0.0 1.8 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 Hydrolase_like PF13242.6 KOO21949.1 - 6.5e-05 22.9 0.1 0.00011 22.2 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KOO21949.1 - 0.00013 22.1 0.1 0.0083 16.2 0.0 2.1 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase ssDNA-exonuc_C PF10141.9 KOO21950.1 - 0.14 11.8 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain Gly-zipper_YMGG PF13441.6 KOO21951.1 - 9.5 6.1 11.0 4.3 7.1 7.0 2.3 1 1 1 2 2 2 0 YMGG-like Gly-zipper Glyco_transf_34 PF05637.12 KOO21952.1 - 0.072 12.8 1.4 0.073 12.8 0.2 1.5 2 0 0 2 2 2 0 galactosyl transferase GMA12/MNN10 family MHB PF16525.5 KOO21952.1 - 0.13 12.5 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 Haemophore, haem-binding Ig_mannosidase PF17753.1 KOO21953.1 - 2.2e-13 49.7 0.0 4.3e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 KOO21953.1 - 5.4e-10 39.8 0.0 1.4e-09 38.4 0.0 1.8 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_C PF02836.17 KOO21953.1 - 0.002 17.3 0.0 0.0039 16.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 KOO21953.1 - 0.0036 18.0 0.0 0.0075 16.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 CH PF00307.31 KOO21954.1 - 5.2e-25 87.7 0.0 7.9e-11 42.1 0.1 3.1 4 0 0 4 4 4 2 Calponin homology (CH) domain EF-hand_7 PF13499.6 KOO21954.1 - 5.1e-07 30.1 0.0 1.2e-05 25.6 0.0 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO21954.1 - 0.00032 20.0 0.1 0.15 11.7 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO21954.1 - 0.004 17.0 0.0 6.9 6.9 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_10 PF14788.6 KOO21954.1 - 0.034 14.0 0.2 9.1 6.2 0.0 2.6 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 KOO21954.1 - 0.14 12.0 0.0 0.89 9.5 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 KOO21954.1 - 0.23 11.0 0.6 7.4 6.3 0.0 3.0 3 0 0 3 3 3 0 EF hand PhyH PF05721.13 KOO21955.1 - 9.4e-13 48.9 0.8 9.2e-12 45.7 0.8 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Methyltransf_11 PF08241.12 KOO21956.1 - 1.6e-08 35.0 1.2 3.4e-08 34.0 0.2 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO21956.1 - 3.5e-08 34.1 0.2 3.5e-08 34.1 0.2 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO21956.1 - 5.6e-08 33.4 0.0 1.5e-07 32.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO21956.1 - 4.8e-06 26.4 0.0 8.8e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO21956.1 - 0.00021 21.1 0.0 0.00033 20.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO21956.1 - 0.0099 15.4 0.2 0.045 13.3 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase small domain FlxA PF14282.6 KOO21956.1 - 0.027 14.4 0.3 0.051 13.6 0.3 1.4 1 0 0 1 1 1 0 FlxA-like protein Ubie_methyltran PF01209.18 KOO21956.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SHR-BD PF06650.12 KOO21958.1 - 7.3e-18 64.9 0.0 2.7e-15 56.5 0.0 2.7 2 1 0 2 2 2 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 KOO21958.1 - 7.6e-05 22.6 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal DUF3458_C PF17432.2 KOO21959.1 - 1.4e-108 363.1 3.0 2.2e-108 362.4 3.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 KOO21959.1 - 4.7e-50 170.2 0.1 8.6e-50 169.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 KOO21959.1 - 3.4e-32 110.8 0.1 8.7e-32 109.4 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 KOO21959.1 - 7e-14 52.4 0.0 1.2e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 KOO21959.1 - 0.071 13.5 0.1 0.23 11.9 0.1 2.0 1 1 0 1 1 1 0 M61 glycyl aminopeptidase Ion_trans PF00520.31 KOO21960.1 - 1.5e-15 57.1 10.5 9.6e-09 34.8 1.6 2.1 2 0 0 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 KOO21960.1 - 6.1e-11 42.1 0.9 6.1e-11 42.1 0.9 2.3 2 0 0 2 2 2 1 Ion channel cNMP_binding PF00027.29 KOO21960.1 - 0.026 14.6 0.0 1.4 9.0 0.0 2.7 2 0 0 2 2 2 0 Cyclic nucleotide-binding domain ChAPs PF09295.10 KOO21960.1 - 0.24 10.4 0.0 0.39 9.7 0.0 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) LRR_5 PF13306.6 KOO21961.1 - 5.4e-199 650.4 0.0 2.4e-37 127.7 0.0 5.6 1 1 5 6 6 6 6 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO21961.1 - 2.7e-32 110.3 0.0 0.027 14.2 0.0 12.9 2 1 16 18 18 18 15 Leucine rich repeat Forkhead_N PF08430.12 KOO21961.1 - 5.9 7.5 43.5 1.2e+02 3.3 10.0 6.0 1 1 2 3 3 3 0 Forkhead N-terminal region LRR_5 PF13306.6 KOO21962.1 - 1.1e-100 332.5 0.0 7.8e-36 122.9 0.1 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO21962.1 - 2.1e-19 69.0 0.0 0.0083 15.9 0.0 7.7 2 1 9 11 11 11 10 Leucine rich repeat WW PF00397.26 KOO21962.1 - 4.4e-11 42.7 0.1 7.2e-11 42.0 0.1 1.3 1 0 0 1 1 1 1 WW domain LRR_4 PF12799.7 KOO21962.1 - 5.8e-05 23.4 0.3 92 3.7 0.0 6.8 2 1 7 9 9 9 0 Leucine Rich repeats (2 copies) AAA PF00004.29 KOO21963.1 - 3.3e-31 108.5 0.0 4.3e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO21963.1 - 9.4e-07 29.4 0.2 5.1e-05 23.7 0.2 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KOO21963.1 - 4.9e-05 23.5 0.0 0.00011 22.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 KOO21963.1 - 8.1e-05 22.3 0.6 0.011 15.3 0.5 2.1 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KOO21963.1 - 0.00018 21.3 0.0 0.00027 20.7 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 KOO21963.1 - 0.00025 21.0 0.1 0.00079 19.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO21963.1 - 0.00049 20.4 0.0 0.0045 17.3 0.1 2.0 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 KOO21963.1 - 0.0011 18.8 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 KOO21963.1 - 0.0012 18.1 0.0 0.0015 17.8 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 KOO21963.1 - 0.003 17.7 0.0 0.0041 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOO21963.1 - 0.0035 17.7 0.0 0.0048 17.3 0.0 1.4 1 1 0 1 1 1 1 RNA helicase PhoH PF02562.16 KOO21963.1 - 0.006 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein NACHT PF05729.12 KOO21963.1 - 0.0076 16.2 0.1 0.028 14.4 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.6 KOO21963.1 - 0.0081 16.4 0.0 0.01 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 KOO21963.1 - 0.017 14.8 0.0 0.038 13.7 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 KOO21963.1 - 0.018 15.1 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 KOO21963.1 - 0.019 14.4 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 KOO21963.1 - 0.021 15.3 0.0 0.028 15.0 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 KOO21963.1 - 0.061 13.0 0.0 0.085 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOO21963.1 - 0.072 13.1 0.0 0.094 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KOO21963.1 - 0.081 12.8 0.0 0.096 12.6 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 KOO21963.1 - 0.084 12.8 0.0 0.25 11.2 0.0 1.6 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 KOO21963.1 - 0.12 12.9 0.0 0.15 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOO21963.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 KOO21963.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.5 1 1 0 1 1 1 0 Sigma-54 interaction domain SBBP PF06739.11 KOO21965.1 - 2e-25 88.5 83.9 3.6e-05 23.7 1.6 12.4 13 0 0 13 13 13 9 Beta-propeller repeat DUF3712 PF12505.8 KOO21965.1 - 0.0061 16.8 1.5 57 4.0 0.0 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3712) PcrB PF01884.17 KOO21965.1 - 0.19 11.2 5.5 26 4.2 0.0 5.2 7 0 0 7 7 7 0 PcrB family DUF1398 PF07166.11 KOO21965.1 - 2.3 8.3 7.2 1.8e+02 2.2 0.1 5.8 7 0 0 7 7 7 0 Protein of unknown function (DUF1398) Ctr PF04145.15 KOO21966.1 - 1.9e-11 44.8 7.0 4.5e-10 40.3 4.1 2.2 1 1 1 2 2 2 2 Ctr copper transporter family HMA PF00403.26 KOO21966.1 - 2.3e-10 40.7 0.6 3.4e-10 40.2 0.6 1.2 1 0 0 1 1 1 1 Heavy-metal-associated domain TRAM_LAG1_CLN8 PF03798.16 KOO21967.1 - 2.7e-10 40.3 13.9 3.2e-10 40.1 13.9 1.1 1 0 0 1 1 1 1 TLC domain LRR_6 PF13516.6 KOO21970.1 - 5.6e-10 38.5 9.3 0.0063 16.5 0.4 5.2 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 KOO21970.1 - 0.00019 21.7 4.1 0.65 10.5 0.1 3.9 2 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO21970.1 - 0.021 14.6 0.2 32 4.4 0.0 4.0 4 0 0 4 4 4 0 Leucine rich repeat LRR_1 PF00560.33 KOO21970.1 - 0.39 11.4 5.8 21 6.1 0.0 4.4 4 1 1 5 5 5 0 Leucine Rich Repeat Methyltransf_21 PF05050.12 KOO21971.1 - 1e-09 38.7 0.0 1.4e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain RPN5_C PF18098.1 KOO21972.1 - 2.1e-15 56.5 1.7 5.1e-15 55.3 1.7 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain PCI PF01399.27 KOO21972.1 - 8.8e-15 55.1 0.4 2.2e-14 53.8 0.1 1.9 2 0 0 2 2 2 1 PCI domain AcetDehyd-dimer PF09290.11 KOO21972.1 - 0.13 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation WD40 PF00400.32 KOO21973.1 - 1.8e-12 47.5 10.5 0.00069 20.4 0.1 5.5 6 0 0 6 6 6 4 WD domain, G-beta repeat DUF962 PF06127.11 KOO21973.1 - 0.00054 20.0 0.3 0.00097 19.2 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF962) ANAPC4_WD40 PF12894.7 KOO21973.1 - 0.00096 19.4 0.0 6.9 7.1 0.0 4.3 3 2 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO21973.1 - 0.05 12.6 0.0 0.59 9.0 0.0 2.3 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Trypan_PARP PF05887.11 KOO21973.1 - 0.11 12.4 3.5 0.23 11.5 3.5 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MFS_1 PF07690.16 KOO21975.1 - 1.8e-17 63.3 20.3 1.8e-17 63.3 20.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily LRV PF01816.17 KOO21975.1 - 2.6 8.6 6.3 1.8 9.1 2.5 2.9 2 0 0 2 2 2 0 Leucine rich repeat variant Ion_trans PF00520.31 KOO21976.1 - 2.9e-190 629.3 64.3 8.8e-55 185.6 7.1 4.5 4 1 0 4 4 4 4 Ion transport protein Thioredoxin PF00085.20 KOO21976.1 - 1.6e-22 79.4 0.0 3e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TPR_20 PF14561.6 KOO21976.1 - 8.9e-19 67.6 1.7 1.9e-18 66.5 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat PKD_channel PF08016.12 KOO21976.1 - 2.5e-10 39.6 63.5 2.3e-05 23.3 1.2 8.6 5 4 4 9 9 9 5 Polycystin cation channel GPHH PF16905.5 KOO21976.1 - 1.1e-07 31.6 0.0 2.6e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated AhpC-TSA PF00578.21 KOO21976.1 - 1.6e-05 24.8 0.0 3.2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 KOO21976.1 - 1.6e-05 25.3 0.0 5.8e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOO21976.1 - 0.00057 20.2 0.0 0.0034 17.7 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like Redoxin PF08534.10 KOO21976.1 - 0.016 14.9 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 Redoxin DUF3935 PF13071.6 KOO21976.1 - 1.5 9.4 23.4 9.9 6.8 0.1 5.2 4 1 1 5 5 5 0 Protein of unknown function (DUF3935) TPR_19 PF14559.6 KOO21976.1 - 3.4 8.2 7.1 1.5 9.4 0.5 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat tRNA_int_end_N2 PF12928.7 KOO21977.1 - 1e-06 28.8 0.0 2.4e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term DFRP_C PF16543.5 KOO21978.1 - 4.6e-11 43.1 1.7 4.6e-11 43.1 1.7 3.0 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 Ion_trans PF00520.31 KOO21978.1 - 8.2e-07 28.5 0.6 8.2e-07 28.5 0.6 1.8 2 0 0 2 2 2 1 Ion transport protein 2OG-FeII_Oxy PF03171.20 KOO21980.1 - 2.4e-18 66.5 0.0 4e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 KOO21980.1 - 4.2e-16 59.8 0.0 4.8e-15 56.4 0.0 2.1 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal EF-hand_1 PF00036.32 KOO21982.1 - 3.6e-12 44.9 0.6 1.6e-05 24.1 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO21982.1 - 1.7e-10 40.0 0.7 7.5e-05 22.4 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO21982.1 - 7.8e-10 37.8 1.7 9.6e-05 21.7 0.7 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO21982.1 - 4.8e-09 36.5 0.6 1.9e-08 34.6 0.6 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO21982.1 - 1.2e-06 28.2 2.3 0.012 15.5 0.3 2.7 1 1 1 2 2 2 2 EF-hand domain pair LRR_6 PF13516.6 KOO21982.1 - 4.8e-06 26.2 1.8 0.058 13.5 0.2 4.2 5 0 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.7 KOO21982.1 - 0.00015 22.1 0.1 1.5 9.3 0.0 3.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO21982.1 - 0.0057 16.4 0.7 5.6 6.8 0.0 3.5 3 1 0 3 3 3 2 Leucine rich repeat GLTT PF01744.20 KOO21982.1 - 4.2 7.2 6.2 4.8 7.0 3.1 2.5 2 0 0 2 2 2 0 GLTT repeat (6 copies) Tyr-DNA_phospho PF06087.12 KOO21984.1 - 3.6e-09 36.0 0.0 5.8e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase HAD_2 PF13419.6 KOO21984.1 - 4.8e-06 26.8 0.0 8.3e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO21984.1 - 8e-05 22.6 0.1 0.0002 21.4 0.1 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Tyr-DNA_phospho PF06087.12 KOO21985.1 - 9.8e-08 31.3 0.0 0.00016 20.7 0.0 2.6 1 1 1 2 2 2 2 Tyrosyl-DNA phosphodiesterase EMP70 PF02990.16 KOO21987.1 - 1.3e-194 647.7 7.3 2.1e-194 647.0 7.3 1.3 1 0 0 1 1 1 1 Endomembrane protein 70 Band_7 PF01145.25 KOO21989.1 - 0.0033 17.5 0.3 0.0033 17.5 0.3 2.1 1 1 1 2 2 2 1 SPFH domain / Band 7 family Cep57_CLD PF14073.6 KOO21989.1 - 0.053 13.5 10.8 0.079 13.0 10.8 1.2 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 Ank_2 PF12796.7 KOO21990.1 - 4.9e-08 33.5 0.0 1.7e-06 28.6 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO21990.1 - 8.6e-06 25.9 0.0 0.0021 18.3 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO21990.1 - 3.4e-05 24.3 0.0 0.0002 21.8 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ART PF01129.18 KOO21990.1 - 7e-05 22.2 0.0 0.00014 21.2 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO21990.1 - 0.00026 20.4 0.0 0.0021 17.5 0.0 2.5 3 1 0 3 3 3 1 ADP-ribosyltransferase exoenzyme Ank_3 PF13606.6 KOO21990.1 - 0.026 15.1 0.0 14 6.7 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat Ank PF00023.30 KOO21990.1 - 0.058 13.9 0.0 2.6 8.7 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat SlyX PF04102.12 KOO21990.1 - 0.058 14.0 7.8 0.045 14.4 4.7 2.5 2 0 0 2 2 1 0 SlyX Atg14 PF10186.9 KOO21990.1 - 0.073 12.1 1.9 0.16 11.0 1.9 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HAP1_N PF04849.13 KOO21990.1 - 0.089 12.0 6.0 0.83 8.8 2.4 2.7 3 0 0 3 3 3 0 HAP1 N-terminal conserved region zf-C4H2 PF10146.9 KOO21990.1 - 0.093 13.0 0.6 0.22 11.8 0.6 1.7 1 0 0 1 1 1 0 Zinc finger-containing protein ADIP PF11559.8 KOO21990.1 - 0.13 12.4 2.4 0.38 10.8 2.4 1.8 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding PC-Esterase PF13839.6 KOO21991.1 - 1.9e-09 37.7 0.0 2.9e-09 37.1 0.0 1.5 1 1 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p DUF4072 PF13284.6 KOO21992.1 - 0.32 11.5 3.4 0.23 11.9 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4072) BLUF PF04940.12 KOO21994.1 - 0.00011 22.3 0.0 0.00021 21.4 0.0 1.4 1 0 0 1 1 1 1 Sensors of blue-light using FAD DnaJ PF00226.31 KOO21995.1 - 0.007 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain DDE_3 PF13358.6 KOO21996.1 - 1.3e-12 47.6 0.0 2e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KOO21996.1 - 0.0008 19.1 0.2 0.011 15.5 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 KOO21996.1 - 0.013 16.1 0.0 0.06 14.0 0.0 2.1 2 0 0 2 2 2 0 Homeodomain-like domain HTH_28 PF13518.6 KOO21996.1 - 0.015 15.4 0.6 0.34 11.1 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_31 PF13560.6 KOO21996.1 - 0.79 10.1 3.8 1.1 9.7 0.1 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain SLBP_RNA_bind PF15247.6 KOO21998.1 - 2.2e-25 88.5 5.4 3.3e-25 88.0 5.4 1.2 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain MMPL PF03176.15 KOO21999.1 - 2e-49 168.4 14.8 6.3e-26 91.1 0.6 2.7 2 1 0 2 2 2 2 MMPL family E1-E2_ATPase PF00122.20 KOO21999.1 - 0.12 11.8 0.1 0.12 11.8 0.1 3.6 5 0 0 5 5 5 0 E1-E2 ATPase MR_MLE_C PF13378.6 KOO22000.1 - 1.8e-50 171.6 0.0 2.5e-50 171.1 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 KOO22000.1 - 1.6e-12 47.7 0.1 3.4e-12 46.6 0.0 1.6 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Rootletin PF15035.6 KOO22001.1 - 0.002 18.2 27.9 0.0036 17.3 11.8 2.8 1 1 1 2 2 2 2 Ciliary rootlet component, centrosome cohesion TFIIA PF03153.13 KOO22001.1 - 1.8 8.5 6.7 2.5 8.0 6.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YabA PF06156.13 KOO22001.1 - 3.4 8.4 21.7 4.7 7.9 0.5 3.9 2 1 2 4 4 4 0 Initiation control protein YabA DUF4094 PF13334.6 KOO22001.1 - 7 7.1 9.3 24 5.4 2.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) BRE1 PF08647.11 KOO22002.1 - 1.1 9.4 6.8 4.1 7.5 0.2 2.7 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase UDPG_MGDP_dh_N PF03721.14 KOO22003.1 - 3.3e-57 193.1 0.1 7.6e-57 191.9 0.0 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 KOO22003.1 - 2.3e-34 118.0 0.1 1e-33 115.9 0.1 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 KOO22003.1 - 4.1e-31 107.1 0.0 1e-30 105.8 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain DUF3456 PF11938.8 KOO22003.1 - 0.019 15.5 2.6 0.076 13.5 0.4 2.4 1 1 1 2 2 2 0 TLR4 regulator and MIR-interacting MSAP PTCB-BRCT PF12738.7 KOO22003.1 - 0.13 12.2 0.1 0.91 9.5 0.0 2.4 2 0 0 2 2 2 0 twin BRCT domain Pkinase PF00069.25 KOO22004.1 - 8.6e-47 159.7 0.0 1e-46 159.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22004.1 - 2.5e-24 86.0 0.0 3.2e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO22004.1 - 0.041 13.2 0.0 1.5 8.1 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 KOO22004.1 - 0.098 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOO22004.1 - 0.16 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 LIM PF00412.22 KOO22005.1 - 0.013 15.7 0.6 0.083 13.1 0.6 2.2 1 1 0 1 1 1 0 LIM domain EF-hand_1 PF00036.32 KOO22006.1 - 2.9e-08 32.7 3.6 0.0018 17.7 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO22006.1 - 4.1e-08 32.4 3.7 0.00027 20.3 0.7 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO22006.1 - 1.1e-06 28.0 1.3 0.036 14.0 0.3 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO22006.1 - 8.2e-05 23.0 1.1 0.43 11.1 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO22006.1 - 0.078 12.8 1.6 5.9 6.8 0.2 2.4 2 0 0 2 2 2 0 EF-hand domain pair DUF711 PF05167.12 KOO22008.1 - 2.2e-89 300.2 0.0 3e-89 299.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised ACR (DUF711) TFIIF_beta_N PF17683.1 KOO22010.1 - 4.3e-08 33.9 0.0 1.1e-07 32.6 0.0 1.8 1 1 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 KOO22010.1 - 4.6e-05 23.5 0.0 9.2e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain FAM184 PF15665.5 KOO22011.1 - 0.00037 20.4 6.0 0.00054 19.8 6.0 1.3 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B Pkinase PF00069.25 KOO22012.1 - 7.5e-52 176.3 0.0 8.5e-52 176.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22012.1 - 3.3e-34 118.3 0.0 4.2e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO22012.1 - 0.00021 20.2 0.0 0.00036 19.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO22012.1 - 0.00034 20.0 0.0 0.00048 19.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO22012.1 - 0.018 15.0 0.5 0.018 15.0 0.5 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO22012.1 - 0.083 12.2 0.2 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Golgin_A5 PF09787.9 KOO22014.1 - 3.3 7.1 71.3 0.03 13.8 7.3 4.1 2 2 2 4 4 4 0 Golgin subfamily A member 5 Lebercilin PF15619.6 KOO22015.1 - 0.014 15.1 0.8 0.049 13.3 0.8 1.9 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease bZIP_1 PF00170.21 KOO22015.1 - 0.12 12.5 1.4 0.25 11.5 0.2 2.2 2 0 0 2 2 2 0 bZIP transcription factor FKBP_C PF00254.28 KOO22016.1 - 2.8e-27 94.9 0.0 5.7e-27 93.9 0.0 1.5 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase 2OG-FeII_Oxy_3 PF13640.6 KOO22017.1 - 1.3e-14 54.9 0.0 2.2e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO22017.1 - 0.0012 19.3 0.0 0.0029 18.0 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 KOO22018.1 - 5.9e-13 49.5 0.0 1.1e-12 48.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO22018.1 - 0.00043 20.7 0.0 0.0011 19.4 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_3 PF01596.17 KOO22019.1 - 4.6e-14 52.1 0.0 6.4e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 KOO22019.1 - 5.5e-09 37.0 0.0 8.6e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO22019.1 - 0.0016 18.2 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DSHCT PF08148.12 KOO22020.1 - 1.7e-32 112.4 0.1 3.2e-32 111.5 0.1 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain Helicase_C PF00271.31 KOO22020.1 - 1.5e-07 31.7 0.0 3.2e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Homeodomain PF00046.29 KOO22020.1 - 0.028 14.3 0.5 4 7.4 0.0 3.7 4 0 0 4 4 4 0 Homeodomain Pkinase PF00069.25 KOO22021.1 - 5.1e-58 196.5 0.0 8.3e-58 195.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22021.1 - 2.2e-35 122.2 0.0 3.2e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO22021.1 - 1.2e-07 31.1 0.0 1.8e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KOO22021.1 - 0.00014 21.3 0.0 0.00032 20.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOO22021.1 - 0.00049 20.1 0.2 0.024 14.6 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 KOO22021.1 - 0.0032 17.1 0.0 0.0064 16.1 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 KOO22021.1 - 0.011 14.5 0.0 0.02 13.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 KOO22021.1 - 0.028 13.5 0.0 0.051 12.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 DNA_pol_E_B PF04042.16 KOO22022.1 - 3.1e-38 131.2 0.0 4.1e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 KOO22022.1 - 2.9e-31 108.3 0.0 4.6e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain RIIa PF02197.17 KOO22022.1 - 0.058 13.1 0.3 8.9 6.1 0.0 2.7 3 0 0 3 3 3 0 Regulatory subunit of type II PKA R-subunit UDG PF03167.19 KOO22023.1 - 3.2e-22 79.2 0.0 4.8e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DUF4407 PF14362.6 KOO22024.1 - 0.16 11.3 29.1 0.075 12.4 0.8 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) DUF842 PF05811.13 KOO22024.1 - 0.2 11.4 5.9 0.16 11.6 2.5 2.4 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) PLAC9 PF15205.6 KOO22024.1 - 0.95 9.9 3.2 33 4.9 0.0 3.4 3 0 0 3 3 3 0 Placenta-specific protein 9 RRM_1 PF00076.22 KOO22025.1 - 3.1e-19 68.6 0.0 7.1e-19 67.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOO22025.1 - 1.5e-06 28.3 0.0 3.4e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 KOO22025.1 - 0.0061 16.2 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATG16 PF08614.11 KOO22025.1 - 0.0072 16.6 20.0 0.0072 16.6 20.0 3.6 2 2 1 3 3 3 1 Autophagy protein 16 (ATG16) Nup35_RRM_2 PF14605.6 KOO22025.1 - 0.037 14.0 0.0 0.063 13.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif FliD_C PF07195.12 KOO22025.1 - 0.13 11.7 5.5 2.2 7.6 0.4 2.5 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus NPV_P10 PF05531.12 KOO22025.1 - 0.31 11.5 6.3 12 6.4 3.5 3.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SART-1 PF03343.13 KOO22025.1 - 0.51 8.8 35.5 0.015 13.9 14.1 2.8 2 1 0 2 2 2 0 SART-1 family Prominin PF05478.11 KOO22025.1 - 0.9 7.4 2.9 1.3 6.9 2.9 1.2 1 0 0 1 1 1 0 Prominin Baculo_PEP_C PF04513.12 KOO22025.1 - 1.3 9.1 4.3 2.1 8.4 2.5 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DAP_epimerase PF01678.19 KOO22026.1 - 5.2e-53 178.3 0.0 1.4e-32 112.4 0.0 2.0 2 0 0 2 2 2 2 Diaminopimelate epimerase UDPGP PF01704.18 KOO22027.1 - 2.4e-18 66.0 0.0 3.2e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NAM-associated PF14303.6 KOO22028.1 - 0.0023 18.7 7.1 0.0028 18.4 7.1 1.2 1 0 0 1 1 1 1 No apical meristem-associated C-terminal domain FAA_hydrolase PF01557.18 KOO22029.1 - 6.8e-59 199.2 0.0 7.5e-59 199.0 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Proteasome PF00227.26 KOO22031.1 - 2.3e-49 167.4 0.1 3.4e-49 166.9 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOO22031.1 - 2.4e-15 55.9 0.1 3.9e-15 55.2 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TTL PF03133.15 KOO22032.1 - 1.6e-51 175.2 0.0 2.2e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family CPSase_L_D2 PF02786.17 KOO22032.1 - 0.00056 19.5 0.0 0.00086 18.9 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_ST PF14397.6 KOO22032.1 - 0.002 17.4 0.0 0.012 14.8 0.0 2.0 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 KOO22032.1 - 0.0024 17.2 0.0 0.0076 15.5 0.0 1.9 2 0 0 2 2 2 1 YheC/D like ATP-grasp RimK PF08443.11 KOO22032.1 - 0.0095 15.5 0.0 0.017 14.7 0.0 1.5 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 KOO22032.1 - 0.032 14.3 0.0 0.1 12.7 0.0 1.7 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp PF02222.22 KOO22032.1 - 0.052 13.1 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_4 PF13535.6 KOO22032.1 - 0.068 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KOO22032.1 - 0.086 12.4 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus GSH-S_ATP PF02955.16 KOO22032.1 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain Tic22 PF04278.12 KOO22033.1 - 0.055 12.8 0.0 0.3 10.4 0.0 1.9 2 0 0 2 2 2 0 Tic22-like family Ala_racemase_N PF01168.20 KOO22034.1 - 1.8e-24 86.6 0.0 2.2e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Senescence PF06911.12 KOO22035.1 - 5.7e-17 62.6 8.2 9e-17 62.0 8.2 1.3 1 0 0 1 1 1 1 Senescence-associated protein PP-binding PF00550.25 KOO22036.1 - 7.3e-16 58.3 0.2 1.1e-15 57.8 0.2 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 KOO22036.1 - 0.00031 20.9 0.6 0.0005 20.2 0.6 1.5 1 1 0 1 1 1 1 Acyl-carrier Ribosomal_L12_N PF16320.5 KOO22036.1 - 0.64 9.8 0.0 0.64 9.8 0.0 3.4 2 1 1 3 3 3 0 Ribosomal protein L7/L12 dimerisation domain Ank_2 PF12796.7 KOO22037.1 - 5.9e-14 52.4 0.3 1.4e-13 51.2 0.1 1.8 2 0 0 2 2 1 1 Ankyrin repeats (3 copies) EF-hand_7 PF13499.6 KOO22037.1 - 9.1e-12 45.3 0.3 3e-05 24.4 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair Ank_4 PF13637.6 KOO22037.1 - 1.9e-10 41.1 3.2 6.7e-07 29.7 0.4 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_1 PF00036.32 KOO22037.1 - 4.6e-10 38.3 1.8 0.041 13.4 0.0 4.4 4 0 0 4 4 4 2 EF hand Ank PF00023.30 KOO22037.1 - 5.6e-09 36.1 0.7 0.0011 19.3 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat EF-hand_6 PF13405.6 KOO22037.1 - 5.7e-09 35.2 1.0 0.13 12.2 0.0 4.3 4 0 0 4 4 4 2 EF-hand domain Ank_5 PF13857.6 KOO22037.1 - 4.6e-08 33.2 0.9 6.1e-05 23.2 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_5 PF13202.6 KOO22037.1 - 3.4e-07 29.5 3.3 0.23 11.0 0.4 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO22037.1 - 1.2e-05 25.1 1.3 0.17 11.7 0.2 4.6 4 1 1 5 5 5 1 EF-hand domain pair Ank_3 PF13606.6 KOO22037.1 - 2.6e-05 24.3 0.6 0.38 11.5 0.2 3.9 3 0 0 3 3 3 1 Ankyrin repeat EF-hand_10 PF14788.6 KOO22037.1 - 0.0071 16.2 2.6 2.6 8.0 0.4 2.6 2 0 0 2 2 2 2 EF hand MRI PF15325.6 KOO22039.1 - 1.4 10.0 10.2 2.3 9.4 9.1 1.8 1 1 1 2 2 2 0 Modulator of retrovirus infection BAF1_ABF1 PF04684.13 KOO22039.1 - 4.9 6.1 4.9 5.4 5.9 4.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Esterase PF00756.20 KOO22040.1 - 3e-47 161.4 0.0 4.4e-47 160.8 0.0 1.2 1 0 0 1 1 1 1 Putative esterase ADH_zinc_N PF00107.26 KOO22040.1 - 2.3e-24 85.8 0.0 5.5e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOO22040.1 - 2.9e-19 68.9 0.8 7.1e-19 67.7 0.8 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Hydrolase_4 PF12146.8 KOO22040.1 - 0.0011 18.3 0.0 0.0023 17.2 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 AlaDh_PNT_C PF01262.21 KOO22040.1 - 0.0018 17.6 0.1 0.003 16.9 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 KOO22040.1 - 0.031 14.5 0.0 0.076 13.3 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 KOO22040.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Peptidase_S9 PF00326.21 KOO22040.1 - 0.16 11.4 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family PrmA PF06325.13 KOO22040.1 - 0.22 10.9 0.1 0.42 10.0 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Pyr_redox_3 PF13738.6 KOO22041.1 - 4.9e-16 58.8 0.0 8.6e-15 54.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOO22041.1 - 2.7e-13 49.8 0.0 4.8e-13 49.0 0.0 1.4 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 KOO22041.1 - 3e-12 45.7 0.0 2.1e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 KOO22041.1 - 2.7e-10 40.0 0.0 4.1e-09 36.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 KOO22041.1 - 0.077 13.1 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Staph_opine_DH PF10100.9 KOO22041.1 - 0.12 11.0 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Staphylopine dehydrogenase FlgT_N PF16548.5 KOO22042.1 - 0.25 11.9 1.7 0.55 10.8 0.2 2.1 2 0 0 2 2 2 0 Flagellar assembly protein T, N-terminal domain Ac76 PF05814.11 KOO22042.1 - 1.2 9.2 5.7 6.8 6.8 2.3 2.8 2 1 0 2 2 2 0 Orf76 (Ac76) Ferric_reduct PF01794.19 KOO22042.1 - 1.4 9.0 17.3 1.5 8.9 0.3 3.0 2 1 0 2 2 2 0 Ferric reductase like transmembrane component DUF996 PF06195.13 KOO22042.1 - 5.4 7.3 15.6 0.15 12.4 6.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF996) 2OG-FeII_Oxy_3 PF13640.6 KOO22043.1 - 4.4e-19 69.2 0.0 1e-18 68.0 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO22043.1 - 1.5e-09 38.4 0.0 2.3e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ion_trans_2 PF07885.16 KOO22044.1 - 5.5e-08 32.7 2.9 5.5e-08 32.7 2.9 2.2 2 1 0 2 2 2 1 Ion channel Ion_trans PF00520.31 KOO22044.1 - 9.2e-07 28.3 0.2 1.8e-06 27.4 0.2 1.4 1 0 0 1 1 1 1 Ion transport protein Orai-1 PF07856.12 KOO22044.1 - 0.31 10.7 0.0 0.31 10.7 0.0 2.3 3 0 0 3 3 3 0 Mediator of CRAC channel activity Chordopox_L2 PF05803.12 KOO22044.1 - 0.33 10.8 2.3 0.4 10.6 0.3 2.0 2 0 0 2 2 2 0 Chordopoxvirus L2 protein UBM PF14377.6 KOO22044.1 - 0.77 9.3 2.7 1.8 8.1 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin binding region cNMP_binding PF00027.29 KOO22045.1 - 5.1e-17 61.7 1.8 5.9e-09 35.9 1.4 5.0 3 1 0 3 3 3 3 Cyclic nucleotide-binding domain Ion_trans PF00520.31 KOO22045.1 - 8.4e-12 44.8 10.8 2.5e-06 26.9 2.4 2.4 2 0 0 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 KOO22045.1 - 0.00089 19.2 12.8 0.0059 16.6 0.4 2.9 2 0 0 2 2 2 2 Ion channel Filamin PF00630.19 KOO22046.1 - 1.6e-08 35.3 0.1 4.4e-06 27.5 0.1 2.1 2 0 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO22046.1 - 0.0002 21.6 0.6 0.0013 19.0 0.2 2.3 1 1 2 3 3 3 1 Invasin, domain 3 Filamin PF00630.19 KOO22047.1 - 1.1e-11 45.4 0.0 0.00054 20.7 0.0 3.2 2 1 1 3 3 3 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO22047.1 - 1.7e-07 31.4 0.0 2.7e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 Invasin, domain 3 LRR_6 PF13516.6 KOO22048.1 - 0.0073 16.3 0.2 0.036 14.1 0.0 2.2 3 0 0 3 3 3 1 Leucine Rich repeat LRR_9 PF14580.6 KOO22048.1 - 0.2 11.1 0.0 0.27 10.7 0.0 1.1 1 0 0 1 1 1 0 Leucine-rich repeat Lipase_GDSL_2 PF13472.6 KOO22049.1 - 0.0021 18.5 0.1 0.12 12.8 0.0 2.4 1 1 1 2 2 2 2 GDSL-like Lipase/Acylhydrolase family FA_hydroxylase PF04116.13 KOO22051.1 - 2.6e-08 34.3 3.2 3.1e-08 34.0 3.2 1.1 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily GPR_Gpa2_C PF11970.8 KOO22052.1 - 0.017 15.2 3.6 0.076 13.1 0.3 2.4 2 1 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term Zip PF02535.22 KOO22053.1 - 5.4e-08 32.4 25.0 3.4e-06 26.5 8.6 2.6 2 1 0 2 2 2 2 ZIP Zinc transporter cNMP_binding PF00027.29 KOO22053.1 - 1.7e-05 24.8 0.0 0.0086 16.1 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain EF-hand_1 PF00036.32 KOO22056.1 - 1.2e-22 77.7 0.5 0.00047 19.5 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO22056.1 - 1.5e-19 68.2 1.0 0.00088 19.0 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO22056.1 - 4e-18 64.0 2.6 0.005 16.3 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO22056.1 - 1.5e-14 54.2 0.1 2.1e-06 28.1 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO22056.1 - 1.6e-09 37.4 2.9 0.017 14.9 0.2 4.4 4 0 0 4 4 4 3 EF-hand domain pair Pkinase PF00069.25 KOO22057.1 - 3.7e-58 197.0 0.0 5e-58 196.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22057.1 - 2.2e-27 96.0 0.0 3e-27 95.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO22057.1 - 2.6e-05 23.7 0.0 6.6e-05 22.4 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 KOO22057.1 - 0.022 13.8 0.5 0.075 12.1 0.5 1.8 1 1 0 1 1 1 0 Seadornavirus VP7 WD40 PF00400.32 KOO22059.1 - 9.4e-08 32.6 18.5 0.29 12.1 0.2 9.5 10 0 0 10 10 10 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 KOO22059.1 - 0.0021 16.9 0.0 1.3 7.7 0.0 2.3 2 0 0 2 2 2 2 Nup133 N terminal like CusF_Ec PF11604.8 KOO22060.1 - 0.036 14.0 0.0 0.99 9.4 0.0 2.4 2 0 0 2 2 2 0 Copper binding periplasmic protein CusF PB1 PF00564.24 KOO22060.1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 PB1 domain Nuc_sug_transp PF04142.15 KOO22061.1 - 2.8e-42 145.0 9.1 3.8e-42 144.6 9.1 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.16 KOO22061.1 - 2.5e-05 23.8 4.2 0.026 13.9 2.8 2.3 1 1 1 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 KOO22061.1 - 0.00047 20.3 2.8 0.00047 20.3 2.8 2.9 3 0 0 3 3 3 2 EamA-like transporter family PUNUT PF16913.5 KOO22061.1 - 0.00061 19.1 6.6 0.00068 19.0 5.1 1.8 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport Mog1 PF04603.12 KOO22063.1 - 2.6e-19 69.9 0.0 3.7e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Ran-interacting Mog1 protein TPR_2 PF07719.17 KOO22063.1 - 2e-06 27.5 8.3 4e-05 23.4 1.4 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22063.1 - 0.00014 22.4 13.2 0.55 11.2 0.0 5.6 5 2 2 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO22063.1 - 0.0002 21.9 4.3 0.041 14.5 0.2 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO22063.1 - 0.00022 21.0 0.0 0.059 13.4 0.0 3.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO22063.1 - 0.00054 20.4 14.0 0.17 12.4 0.1 5.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO22063.1 - 0.00071 19.6 0.5 0.055 13.7 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO22063.1 - 0.0022 17.7 1.4 0.0022 17.7 1.4 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO22063.1 - 0.0049 16.9 0.6 0.46 10.6 0.1 2.6 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 KOO22063.1 - 0.017 15.4 2.1 0.27 11.6 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO22063.1 - 0.026 15.1 3.4 1.7 9.5 0.4 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO22063.1 - 0.032 14.4 1.3 2.8 8.2 0.2 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 KOO22063.1 - 0.045 14.1 1.4 0.35 11.2 0.1 3.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO22063.1 - 0.097 12.6 1.6 1.1 9.2 0.1 3.3 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_15 PF13429.6 KOO22063.1 - 0.22 10.7 2.5 7.8 5.6 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2012 PF09430.10 KOO22064.1 - 8e-18 64.7 0.0 2.5e-17 63.1 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.6 KOO22064.1 - 8.1e-05 22.8 0.1 0.00012 22.3 0.1 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain SOP4 PF17081.5 KOO22064.1 - 0.015 14.8 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 Suppressor of PMA 1-7 protein CarbopepD_reg_2 PF13715.6 KOO22064.1 - 0.03 14.3 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 CarboxypepD_reg-like domain fn3_3 PF14686.6 KOO22064.1 - 0.14 11.9 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain II EF-hand_1 PF00036.32 KOO22066.1 - 1e-23 81.0 9.3 2.8e-05 23.4 0.5 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO22066.1 - 1.2e-21 74.7 7.0 0.00014 21.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO22066.1 - 1.7e-19 68.4 8.9 0.00073 18.9 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO22066.1 - 1.7e-19 70.0 6.8 1.1e-10 41.8 0.2 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO22066.1 - 1.3e-17 63.3 3.4 1.1e-09 38.0 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO22066.1 - 0.0019 18.5 0.2 5.1 7.5 0.0 3.6 3 1 1 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO22066.1 - 0.095 12.6 0.1 21 5.0 0.0 3.1 1 1 2 3 3 3 0 Caleosin related protein EF-hand_9 PF14658.6 KOO22066.1 - 0.12 12.7 0.0 0.64 10.4 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain A_deaminase PF00962.22 KOO22067.1 - 3.1e-29 102.4 0.1 1.3e-18 67.4 0.0 3.4 2 2 0 2 2 2 2 Adenosine/AMP deaminase Ndufs5 PF10200.9 KOO22068.1 - 0.0018 18.5 0.1 0.0044 17.3 0.1 1.7 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Guanylate_cyc PF00211.20 KOO22069.1 - 1e-08 35.0 0.0 1.7e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ion_trans PF00520.31 KOO22069.1 - 0.001 18.4 6.5 0.0011 18.2 3.7 2.1 2 0 0 2 2 2 1 Ion transport protein Galactosyl_T PF01762.21 KOO22070.1 - 0.00032 20.6 0.0 0.00051 19.9 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Nucleos_tra2_C PF07662.13 KOO22072.1 - 4.5e-64 216.1 0.0 1e-63 214.9 0.0 1.6 2 1 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Na_Ca_ex PF01699.24 KOO22074.1 - 3.1e-36 124.6 33.9 6.4e-20 71.7 7.0 2.7 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Calx-beta PF03160.14 KOO22074.1 - 2e-32 111.4 0.2 4.9e-16 58.7 0.0 2.5 2 0 0 2 2 2 2 Calx-beta domain CBF_beta PF02312.17 KOO22074.1 - 0.23 11.1 0.0 6.5 6.4 0.0 2.2 2 0 0 2 2 2 0 Core binding factor beta subunit Fasciclin PF02469.22 KOO22075.1 - 2.4e-72 241.2 0.1 6.9e-35 120.1 0.0 2.3 2 0 0 2 2 2 2 Fasciclin domain AAA PF00004.29 KOO22075.1 - 7.2e-39 133.2 0.0 1.5e-38 132.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO22075.1 - 1.4e-08 34.4 0.0 1.4e-08 34.4 0.0 2.4 3 0 0 3 3 2 1 AAA+ lid domain Vps4_C PF09336.10 KOO22075.1 - 3.7e-06 26.8 0.0 8.3e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 KOO22075.1 - 1.4e-05 24.9 0.2 3.8e-05 23.5 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KOO22075.1 - 6.8e-05 22.9 0.3 0.00032 20.7 0.3 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO22075.1 - 7.4e-05 23.2 0.6 0.0059 17.0 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 KOO22075.1 - 9.7e-05 21.7 0.0 0.00034 19.9 0.0 1.9 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 KOO22075.1 - 0.00013 22.2 0.2 0.04 14.2 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 KOO22075.1 - 0.00031 20.9 0.0 0.00067 19.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 KOO22075.1 - 0.00079 19.2 0.0 0.0019 17.9 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 KOO22075.1 - 0.01 15.2 0.2 0.024 14.0 0.1 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI Cloacin_immun PF03513.14 KOO22075.1 - 0.019 15.3 0.1 1.4 9.3 0.0 2.3 2 0 0 2 2 2 0 Cloacin immunity protein RNA_helicase PF00910.22 KOO22075.1 - 0.02 15.3 0.0 0.039 14.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 KOO22075.1 - 0.021 14.8 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain PcrB PF01884.17 KOO22075.1 - 0.021 14.3 5.3 1.5 8.2 0.5 3.0 3 0 0 3 3 3 0 PcrB family TniB PF05621.11 KOO22075.1 - 0.041 13.3 0.0 7.2 6.0 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein DUF211 PF02680.14 KOO22075.1 - 0.054 13.6 9.9 1.4 9.1 1.5 2.6 2 0 0 2 2 2 0 Uncharacterized ArCR, COG1888 AAA_7 PF12775.7 KOO22075.1 - 0.059 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_17 PF13207.6 KOO22075.1 - 0.086 13.3 0.0 0.44 11.0 0.0 2.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO22075.1 - 0.09 12.9 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KOO22075.1 - 0.096 12.4 0.1 0.96 9.1 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 KOO22075.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 HpaB_N PF11794.8 KOO22075.1 - 0.11 12.2 6.5 2.9 7.5 1.0 2.4 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal AAA_18 PF13238.6 KOO22075.1 - 0.12 13.0 0.0 0.24 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF5495 PF17599.2 KOO22075.1 - 0.18 12.1 0.1 40 4.6 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5495) PhoH PF02562.16 KOO22075.1 - 0.19 11.2 4.4 0.29 10.6 0.1 2.9 3 0 0 3 3 3 0 PhoH-like protein AAA_19 PF13245.6 KOO22075.1 - 8 6.8 9.5 1.5 9.2 0.1 3.4 3 1 1 4 4 4 0 AAA domain TIG PF01833.24 KOO22076.1 - 7e-15 54.9 3.2 1.4e-06 28.2 1.1 3.6 3 0 0 3 3 3 3 IPT/TIG domain TIG PF01833.24 KOO22077.1 - 1.4e-75 249.4 47.6 1.2e-07 31.7 0.1 17.8 16 2 0 16 16 16 15 IPT/TIG domain TIG_plexin PF17960.1 KOO22077.1 - 9.4e-11 41.6 0.3 0.18 11.8 0.0 9.5 12 0 0 12 12 12 2 TIG domain Big_7 PF17957.1 KOO22077.1 - 4.5 8.1 6.5 55 4.6 0.2 5.0 5 0 0 5 5 5 0 Bacterial Ig domain Exostosin PF03016.15 KOO22078.1 - 1.4e-12 47.4 0.0 5e-07 29.2 0.0 2.1 1 1 1 2 2 2 2 Exostosin family Filamin PF00630.19 KOO22079.1 - 4.7e-23 82.0 0.0 6.9e-06 26.8 0.0 6.5 6 0 0 6 6 6 5 Filamin/ABP280 repeat SH3_3 PF08239.11 KOO22079.1 - 0.0053 17.0 0.0 0.028 14.7 0.0 2.3 2 0 0 2 2 2 1 Bacterial SH3 domain Invasin_D3 PF09134.10 KOO22079.1 - 0.0079 16.5 4.9 0.14 12.5 0.3 4.3 4 1 0 4 4 4 1 Invasin, domain 3 PKD_channel PF08016.12 KOO22081.1 - 1.6e-16 60.0 5.8 2.8e-15 55.9 4.8 2.2 2 0 0 2 2 2 2 Polycystin cation channel Ion_trans PF00520.31 KOO22081.1 - 3.2e-08 33.1 9.1 3.2e-08 33.1 9.1 1.4 2 0 0 2 2 2 1 Ion transport protein DUF917 PF06032.12 KOO22081.1 - 0.028 13.3 0.0 0.037 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF917) NaeI PF09126.10 KOO22082.1 - 0.13 11.4 1.2 0.25 10.5 1.2 1.4 1 1 0 1 1 1 0 Restriction endonuclease NaeI Myosin_head PF00063.21 KOO22083.1 - 1.1e-146 489.8 0.0 7.5e-146 487.1 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 KOO22083.1 - 8.2e-05 22.9 0.1 0.0007 19.9 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 KOO22083.1 - 0.0077 16.0 0.8 0.0077 16.0 0.8 2.5 3 0 0 3 3 3 1 AAA domain TsaE PF02367.17 KOO22083.1 - 0.091 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 KOO22083.1 - 0.14 12.6 5.9 0.14 12.6 0.4 3.2 3 1 0 3 3 3 0 AAA ATPase domain Sigma54_activat PF00158.26 KOO22083.1 - 0.14 11.9 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PRK PF00485.18 KOO22083.1 - 0.2 11.4 0.1 1.2 8.9 0.1 2.0 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family VCBS PF13517.6 KOO22084.1 - 2.1e-11 44.3 3.9 0.0083 16.7 0.0 5.0 5 0 0 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_7 PF13499.6 KOO22084.1 - 2.6e-07 31.0 0.0 1e-06 29.1 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair FG-GAP PF01839.23 KOO22084.1 - 1.4e-06 28.3 14.3 0.00035 20.6 1.9 4.5 4 0 0 4 4 4 2 FG-GAP repeat TcdB_toxin_midN PF12256.8 KOO22084.1 - 0.0071 15.7 0.1 3.7 6.9 0.0 2.4 2 0 0 2 2 2 2 Insecticide toxin TcdB middle/N-terminal region TIG PF01833.24 KOO22084.1 - 0.024 14.7 0.0 2.5 8.2 0.0 2.5 2 0 0 2 2 2 0 IPT/TIG domain EF-hand_6 PF13405.6 KOO22084.1 - 0.14 12.2 5.8 0.74 9.9 0.0 3.5 4 0 0 4 4 4 0 EF-hand domain EF-hand_1 PF00036.32 KOO22084.1 - 0.15 11.6 0.0 0.15 11.6 0.0 4.5 6 0 0 6 6 6 0 EF hand EF-hand_5 PF13202.6 KOO22084.1 - 0.4 10.3 0.0 0.4 10.3 0.0 4.1 4 0 0 4 4 4 0 EF hand DUF1658 PF07871.11 KOO22084.1 - 0.87 9.6 4.0 4.1 7.5 2.8 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) Sacchrp_dh_NADP PF03435.18 KOO22085.1 - 6.8e-06 26.4 0.1 1.5e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain SPOR PF05036.13 KOO22085.1 - 0.11 12.9 0.1 0.22 11.9 0.1 1.5 1 0 0 1 1 1 0 Sporulation related domain Shikimate_DH PF01488.20 KOO22085.1 - 0.17 12.0 0.0 0.35 10.9 0.0 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ank_2 PF12796.7 KOO22086.1 - 5.9e-32 110.1 4.5 1.3e-15 57.7 0.6 3.3 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO22086.1 - 6.8e-21 74.1 6.6 2.7e-05 24.4 0.1 4.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO22086.1 - 2.1e-20 72.8 2.8 2.4e-08 34.3 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO22086.1 - 5.2e-15 55.1 18.9 0.0035 17.7 0.2 5.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 KOO22086.1 - 3e-14 51.7 3.8 0.018 15.5 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat WWE PF02825.20 KOO22087.1 - 6.7e-25 87.5 1.4 3.5e-13 49.9 0.0 2.8 2 0 0 2 2 2 2 WWE domain ART PF01129.18 KOO22087.1 - 4.7e-09 35.9 0.0 1.3e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Peptidase_S9 PF00326.21 KOO22088.1 - 0.0067 15.9 0.0 0.0078 15.7 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Ank_2 PF12796.7 KOO22089.1 - 6.3e-60 199.7 22.7 1.3e-16 60.9 0.2 4.7 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO22089.1 - 4.2e-50 167.5 5.5 2.7e-10 40.6 0.0 6.3 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 KOO22089.1 - 1.3e-42 142.4 25.6 2.5e-05 24.5 0.1 9.2 9 1 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 KOO22089.1 - 5.5e-36 122.2 11.2 1.7e-10 40.9 0.1 7.3 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22089.1 - 3.5e-33 109.9 3.4 0.0083 16.6 0.0 8.6 8 0 0 8 8 8 8 Ankyrin repeat THUMP PF02926.17 KOO22089.1 - 3e-05 24.1 0.0 6.7e-05 23.0 0.0 1.5 2 0 0 2 2 2 1 THUMP domain DUF2148 PF09918.9 KOO22089.1 - 0.12 12.5 0.0 0.55 10.3 0.0 2.1 1 0 0 1 1 1 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) Calreticulin PF00262.18 KOO22090.1 - 2.5e-22 79.2 0.0 3.2e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 Calreticulin family Metallophos PF00149.28 KOO22091.1 - 3.9e-38 132.0 0.1 5.3e-38 131.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOO22091.1 - 2e-21 76.1 0.1 4.3e-21 75.1 0.1 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain LRR_6 PF13516.6 KOO22092.1 - 1.4e-38 127.6 100.6 0.0025 17.7 0.3 29.9 33 0 0 33 33 33 13 Leucine Rich repeat LRR_1 PF00560.33 KOO22092.1 - 2e-14 51.9 12.6 66 4.7 0.0 16.3 19 0 0 19 19 16 0 Leucine Rich Repeat EF-hand_1 PF00036.32 KOO22092.1 - 8.8e-08 31.2 1.0 0.0053 16.2 0.0 3.7 3 0 0 3 3 3 2 EF hand LRR_4 PF12799.7 KOO22092.1 - 2.8e-07 30.7 40.9 2.1 8.9 0.3 15.7 16 2 2 18 18 16 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO22092.1 - 7.7e-06 25.6 20.3 22 4.9 0.0 13.6 15 1 0 15 15 15 0 Leucine rich repeat EF-hand_7 PF13499.6 KOO22092.1 - 1.1e-05 25.8 0.4 5.1e-05 23.6 0.4 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO22092.1 - 3.7e-05 23.3 0.6 0.039 13.9 0.0 4.0 2 1 1 3 3 3 1 EF-hand domain SpoU_sub_bind PF08032.12 KOO22092.1 - 0.0016 18.7 1.4 24 5.3 0.1 6.0 5 1 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding DUF2202 PF09968.9 KOO22092.1 - 0.015 15.1 0.0 21 4.9 0.0 3.6 3 0 0 3 3 3 0 Uncharacterized protein domain (DUF2202) UPF0181 PF03701.14 KOO22092.1 - 0.2 11.3 6.7 88 2.8 0.1 6.3 8 0 0 8 8 8 0 Uncharacterised protein family (UPF0181) Parecho_VpG PF06344.11 KOO22092.1 - 0.24 12.1 4.8 54 4.8 0.1 3.9 3 0 0 3 3 3 0 Parechovirus Genome-linked protein dUTPase PF00692.19 KOO22093.1 - 3.4e-45 152.9 0.0 4e-45 152.6 0.0 1.0 1 0 0 1 1 1 1 dUTPase DLH PF01738.18 KOO22094.1 - 2e-22 79.8 0.0 2.4e-22 79.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 KOO22094.1 - 0.0045 16.3 0.0 0.0087 15.3 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 AXE1 PF05448.12 KOO22094.1 - 0.16 10.7 0.0 0.49 9.0 0.0 1.7 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Kinesin PF00225.23 KOO22096.1 - 9.8e-81 271.2 0.1 1.5e-39 135.9 0.6 3.7 3 0 0 3 3 3 3 Kinesin motor domain Microtub_bd PF16796.5 KOO22096.1 - 2.5e-18 66.4 0.0 1.3e-17 64.1 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding SURF4 PF02077.15 KOO22098.1 - 5.6e-26 91.7 0.1 5.6e-19 68.8 0.1 2.0 2 0 0 2 2 2 2 SURF4 family DoxX PF07681.12 KOO22098.1 - 0.056 14.0 1.5 0.056 14.0 1.5 2.7 3 0 0 3 3 3 0 DoxX Wzy_C PF04932.15 KOO22098.1 - 3.1 7.4 5.9 0.3 10.7 1.0 1.8 2 1 0 2 2 2 0 O-Antigen ligase GST_C_3 PF14497.6 KOO22099.1 - 4.4e-10 39.6 0.0 6.2e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOO22099.1 - 0.001 19.0 0.0 0.0026 17.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOO22099.1 - 0.0037 17.4 0.0 0.0057 16.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Beta-lactamase PF00144.24 KOO22100.1 - 3.3e-21 75.9 5.0 9.6e-21 74.4 5.0 1.6 1 1 0 1 1 1 1 Beta-lactamase IL32 PF15225.6 KOO22101.1 - 0.0049 17.2 0.4 0.01 16.2 0.4 1.5 1 0 0 1 1 1 1 Interleukin 32 PBP_N PF17093.5 KOO22101.1 - 0.0089 16.3 1.6 0.0089 16.3 1.6 1.8 2 0 0 2 2 2 1 Penicillin-binding protein N-terminus MCU PF04678.13 KOO22101.1 - 0.084 13.0 0.5 0.22 11.6 0.1 1.7 2 0 0 2 2 2 0 Mitochondrial calcium uniporter LRR_6 PF13516.6 KOO22103.1 - 1.9e-16 58.6 2.3 1.8e-05 24.4 0.0 3.5 4 0 0 4 4 4 3 Leucine Rich repeat HOASN PF14515.6 KOO22103.1 - 0.081 13.3 4.6 8.2 6.9 0.1 2.9 1 1 2 3 3 3 0 Haem-oxygenase-associated N-terminal helices YycC PF14174.6 KOO22103.1 - 0.18 11.6 0.0 28 4.6 0.0 2.5 3 0 0 3 3 3 0 YycC-like protein SpoVAB PF13782.6 KOO22103.1 - 0.69 10.2 3.6 40 4.5 0.1 3.0 3 0 0 3 3 3 0 Stage V sporulation protein AB zf-RING_2 PF13639.6 KOO22106.1 - 2.3e-08 34.3 14.2 3.7e-08 33.6 14.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KOO22106.1 - 1.9e-07 30.8 8.9 2.9e-07 30.2 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO22106.1 - 3.2e-07 30.2 11.7 5.9e-07 29.4 11.7 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KOO22106.1 - 1e-06 28.9 8.8 1.8e-06 28.1 8.8 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOO22106.1 - 1.5e-06 28.0 14.5 2.4e-06 27.3 14.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOO22106.1 - 5.8e-06 26.4 13.9 1e-05 25.6 13.9 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 KOO22106.1 - 2.1e-05 24.2 13.0 3.8e-05 23.4 13.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO22106.1 - 0.00041 20.2 11.9 0.00078 19.3 11.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOO22106.1 - 0.00082 19.3 12.0 0.0014 18.6 12.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KOO22106.1 - 0.0048 16.9 3.1 0.011 15.8 3.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 KOO22106.1 - 0.65 9.9 5.9 1.1 9.2 5.9 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 KOO22106.1 - 1 9.0 10.1 2 8.1 10.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_6 PF14835.6 KOO22106.1 - 1.8 8.5 6.6 4.5 7.2 6.6 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 KOO22106.1 - 2.8 7.8 7.6 7.7 6.4 7.6 1.8 1 1 0 1 1 1 0 RING-like zinc finger zf-P11 PF03854.14 KOO22106.1 - 2.9 7.6 9.1 3.7 7.3 4.6 2.8 2 1 1 3 3 3 0 P-11 zinc finger IQ PF00612.27 KOO22107.1 - 0.00065 19.3 0.4 0.0016 18.1 0.4 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif SlyX PF04102.12 KOO22107.1 - 0.02 15.5 1.1 0.05 14.2 1.1 1.7 1 0 0 1 1 1 0 SlyX PseudoU_synth_1 PF01416.20 KOO22108.1 - 1.8e-28 99.1 0.0 2.6e-19 69.7 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase SBBP PF06739.11 KOO22109.1 - 6.4e-15 54.9 23.6 0.00014 21.8 0.5 6.5 6 0 0 6 6 6 5 Beta-propeller repeat CcmD PF04995.14 KOO22109.1 - 0.032 14.3 0.4 0.032 14.3 0.4 2.5 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Lactamase_B PF00753.27 KOO22109.1 - 0.072 13.1 4.7 1.2 9.1 0.4 2.9 1 1 0 2 2 2 0 Metallo-beta-lactamase superfamily DUF2681 PF10883.8 KOO22109.1 - 0.26 11.7 0.1 0.48 10.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF2625 PF10946.8 KOO22109.1 - 0.57 9.2 10.5 1.8 7.6 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function DUF2625 DUF3767 PF12597.8 KOO22109.1 - 6.1 6.7 6.0 6.5 6.6 0.2 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3767) DUF21 PF01595.20 KOO22110.1 - 1.6e-36 125.7 5.9 2.8e-36 124.9 5.9 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 KOO22110.1 - 1.4e-15 57.0 0.1 3.3e-15 55.8 0.1 1.6 1 0 0 1 1 1 1 Transporter associated domain CBS PF00571.28 KOO22110.1 - 8.1e-13 48.6 0.8 9.7e-07 29.1 0.1 2.5 2 0 0 2 2 2 2 CBS domain SapC PF07277.11 KOO22111.1 - 0.0062 16.1 0.6 0.013 15.1 0.6 1.6 1 0 0 1 1 1 1 SapC Mucin-like PF16058.5 KOO22111.1 - 0.0096 16.0 2.9 0.021 14.9 2.9 1.5 1 0 0 1 1 1 1 Mucin-like DUF4410 PF14366.6 KOO22111.1 - 3.7 7.5 7.8 0.87 9.5 3.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4410) Glu_synthase PF01645.17 KOO22112.1 - 1.3e-147 491.7 1.3 2.3e-146 487.7 0.0 2.1 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.21 KOO22112.1 - 7e-147 489.5 0.0 1e-146 489.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.14 KOO22112.1 - 3.5e-100 335.1 0.0 9.8e-100 333.6 0.0 1.7 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 KOO22112.1 - 9.1e-62 208.0 3.2 1.7e-61 207.1 3.2 1.4 1 0 0 1 1 1 1 GXGXG motif FMN_dh PF01070.18 KOO22112.1 - 0.48 9.4 3.6 0.95 8.4 3.6 1.4 1 0 0 1 1 1 0 FMN-dependent dehydrogenase LRR_6 PF13516.6 KOO22114.1 - 0.006 16.5 0.0 0.019 15.0 0.0 1.9 1 0 0 1 1 1 1 Leucine Rich repeat BSD PF03909.17 KOO22115.1 - 0.00019 21.3 0.0 0.00042 20.3 0.0 1.5 1 0 0 1 1 1 1 BSD domain Cytidylate_kin PF02224.18 KOO22115.1 - 0.00051 19.8 0.0 0.0059 16.4 0.0 2.2 2 0 0 2 2 2 1 Cytidylate kinase AAA_17 PF13207.6 KOO22115.1 - 0.067 13.6 0.0 0.22 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain Utp12 PF04003.12 KOO22116.1 - 4 7.8 5.5 0.86 9.9 1.3 2.0 2 1 0 2 2 2 0 Dip2/Utp12 Family Tricorn_PDZ PF14685.6 KOO22117.1 - 1.1e-05 25.2 1.1 0.034 14.1 0.0 3.0 2 1 1 3 3 3 2 Tricorn protease PDZ domain PDZ PF00595.24 KOO22117.1 - 0.00021 21.6 0.7 0.00078 19.8 0.1 2.1 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO22117.1 - 0.024 15.0 0.2 0.93 9.9 0.1 2.3 2 1 0 2 2 2 0 PDZ domain Acylphosphatase PF00708.18 KOO22117.1 - 0.091 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Acylphosphatase RRM_1 PF00076.22 KOO22118.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3328 PF11807.8 KOO22118.1 - 0.14 11.9 0.1 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Nup96 PF12110.8 KOO22119.1 - 3.9e-07 29.5 0.0 7.2e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Nuclear protein 96 FHA PF00498.26 KOO22120.1 - 4.8e-14 52.5 0.0 8.3e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 FHA domain Drf_GBD PF06371.13 KOO22120.1 - 1.1e-06 28.3 0.0 1.7e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Yop-YscD_cpl PF16697.5 KOO22120.1 - 0.0059 16.9 0.0 0.86 10.0 0.0 2.9 2 1 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF3361 PF11841.8 KOO22120.1 - 0.016 15.2 0.0 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) EF-hand_7 PF13499.6 KOO22121.1 - 9.1e-14 51.7 0.9 2.4e-11 43.9 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO22121.1 - 1.2e-11 43.3 0.7 0.00014 21.2 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO22121.1 - 1.3e-09 37.2 0.3 0.00011 21.8 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO22121.1 - 4.1e-09 35.5 9.0 0.00042 19.7 0.4 4.4 6 0 0 6 6 6 2 EF hand EF-hand_8 PF13833.6 KOO22121.1 - 6.4e-08 32.3 0.8 2.8e-07 30.3 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO22121.1 - 6.2e-06 26.5 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO22121.1 - 0.075 13.4 0.0 0.3 11.4 0.0 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Peptidase_M17 PF00883.21 KOO22122.1 - 5.6e-53 180.2 0.0 1.1e-52 179.3 0.0 1.5 1 1 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain DUF3318 PF11780.8 KOO22122.1 - 0.13 12.2 0.0 0.36 10.8 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3318) LRR_6 PF13516.6 KOO22123.1 - 4.5e-24 82.4 16.6 0.00061 19.6 0.2 8.2 8 0 0 8 8 8 6 Leucine Rich repeat LRR_1 PF00560.33 KOO22123.1 - 1.6e-05 24.8 1.8 17 6.4 0.0 6.6 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_4 PF12799.7 KOO22123.1 - 0.025 15.0 8.3 0.53 10.8 0.0 4.8 2 1 4 6 6 6 0 Leucine Rich repeats (2 copies) LRR_4 PF12799.7 KOO22124.1 - 1.7e-14 53.7 41.2 0.00043 20.6 1.0 9.9 7 3 3 10 10 10 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO22124.1 - 3.1e-14 52.5 36.1 4.3e-07 29.6 6.5 8.9 5 4 3 8 8 8 5 Leucine rich repeat Roc PF08477.13 KOO22124.1 - 3.7e-11 43.3 0.0 9.2e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_6 PF13516.6 KOO22124.1 - 1.1e-09 37.6 50.4 0.038 14.0 0.5 14.0 13 0 0 13 13 13 4 Leucine Rich repeat Ras PF00071.22 KOO22124.1 - 2e-07 30.8 0.0 4.3e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Ras family LRR_1 PF00560.33 KOO22124.1 - 0.00039 20.6 21.3 30 5.7 0.0 9.7 9 0 0 9 9 9 0 Leucine Rich Repeat Med3 PF11593.8 KOO22124.1 - 0.0057 15.9 4.4 0.01 15.0 4.4 1.3 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Arf PF00025.21 KOO22124.1 - 0.0071 15.8 0.0 0.017 14.6 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA PF00004.29 KOO22124.1 - 0.014 15.8 0.0 0.061 13.7 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) LRR_9 PF14580.6 KOO22124.1 - 0.022 14.3 0.8 0.11 12.0 0.8 2.2 1 0 0 1 1 1 0 Leucine-rich repeat Gtr1_RagA PF04670.12 KOO22124.1 - 0.025 13.9 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_19 PF13245.6 KOO22124.1 - 0.089 13.1 0.0 0.33 11.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain COR PF16095.5 KOO22124.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 C-terminal of Roc, COR, domain TruB_N PF01509.18 KOO22124.1 - 0.18 12.2 0.1 0.52 10.7 0.1 1.7 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) Fer4_12 PF13353.6 KOO22125.1 - 3.4e-10 40.3 0.0 5.2e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 KOO22125.1 - 1.5e-08 35.2 0.0 2.1e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 KOO22125.1 - 5.2e-07 29.8 0.0 7.9e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain ThiF PF00899.21 KOO22127.1 - 2.9e-83 279.0 0.0 9.1e-61 205.3 0.0 3.1 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 KOO22127.1 - 1.4e-65 221.7 0.0 2.3e-65 221.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_4HB PF16191.5 KOO22127.1 - 1.6e-13 50.6 0.0 5.7e-13 48.9 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle LRR_6 PF13516.6 KOO22127.1 - 2e-08 33.6 0.1 0.065 13.3 0.0 4.8 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 KOO22127.1 - 0.03 14.7 0.0 10 6.7 0.0 2.8 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) CYTH PF01928.21 KOO22128.1 - 3.2e-09 37.0 0.0 4.4e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 CYTH domain SelR PF01641.18 KOO22131.1 - 3.1e-18 66.0 0.2 6.6e-18 65.0 0.2 1.5 1 0 0 1 1 1 1 SelR domain GAF_2 PF13185.6 KOO22131.1 - 1.8e-07 31.5 0.1 3.9e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 KOO22131.1 - 1.7e-06 28.7 0.0 5.3e-06 27.1 0.0 1.9 2 0 0 2 2 2 1 GAF domain Endonuclease_7 PF02945.15 KOO22131.1 - 0.074 13.0 1.4 1.7 8.6 1.4 2.4 1 1 0 1 1 1 0 Recombination endonuclease VII Yippee-Mis18 PF03226.14 KOO22131.1 - 0.35 11.1 1.8 0.94 9.7 1.8 1.7 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly TPR_1 PF00515.28 KOO22132.1 - 2.3e-35 118.9 9.1 4e-06 26.4 0.0 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOO22132.1 - 6.7e-31 103.9 15.6 5e-05 23.1 0.1 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 KOO22132.1 - 2e-30 104.2 26.2 2.5e-08 33.5 2.1 6.7 2 2 3 6 6 6 5 TPR repeat TPR_17 PF13431.6 KOO22132.1 - 4.9e-24 82.9 16.8 0.00016 21.8 0.4 8.4 7 1 2 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOO22132.1 - 1.4e-22 79.7 26.3 6.6e-10 39.1 3.7 5.4 1 1 3 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO22132.1 - 2.1e-22 77.4 5.9 0.00021 21.2 0.0 7.0 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 KOO22132.1 - 1.3e-20 71.8 7.9 0.0006 19.7 0.0 6.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22132.1 - 2.4e-19 68.4 28.9 0.0016 19.1 0.2 8.0 3 2 4 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 KOO22132.1 - 1.6e-18 65.9 35.5 0.00029 20.6 0.0 7.8 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 KOO22132.1 - 2.5e-15 56.8 41.1 2.3e-07 31.3 10.4 5.9 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO22132.1 - 5.9e-13 49.1 18.2 8.6e-06 26.2 0.3 5.3 4 1 0 5 5 4 3 Tetratricopeptide repeat Lipase_3 PF01764.25 KOO22132.1 - 5.7e-12 45.7 0.0 1.6e-11 44.3 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) TPR_9 PF13371.6 KOO22132.1 - 2.3e-07 30.8 16.1 0.00037 20.6 0.1 4.9 2 2 4 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 KOO22132.1 - 9e-05 21.8 13.0 0.0087 15.3 3.6 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_4 PF07721.14 KOO22132.1 - 0.0001 22.5 30.0 1.5 9.7 0.0 8.3 8 0 0 8 8 7 3 Tetratricopeptide repeat Abhydrolase_6 PF12697.7 KOO22132.1 - 0.016 15.8 1.2 0.016 15.8 1.2 3.5 1 1 1 3 3 2 0 Alpha/beta hydrolase family TPR_6 PF13174.6 KOO22132.1 - 0.05 14.3 16.3 8.7 7.2 1.5 6.6 6 1 1 7 7 6 0 Tetratricopeptide repeat BTAD PF03704.17 KOO22132.1 - 0.11 13.0 16.6 0.3 11.5 1.4 4.0 1 1 1 3 3 3 0 Bacterial transcriptional activator domain NARP1 PF12569.8 KOO22132.1 - 0.11 11.3 0.3 1.1 8.0 0.0 2.4 1 1 2 3 3 3 0 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 KOO22132.1 - 3.7 7.9 6.4 2.2 8.7 0.5 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat RRM_1 PF00076.22 KOO22133.1 - 0.00011 21.9 0.0 0.00031 20.5 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DEAD PF00270.29 KOO22134.1 - 1.2e-49 168.4 0.0 2.4e-49 167.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO22134.1 - 5.6e-20 71.7 0.0 3.3e-19 69.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOO22134.1 - 0.0029 17.9 0.2 0.68 10.2 0.0 2.6 2 1 0 2 2 2 2 AAA domain IATP PF04568.12 KOO22134.1 - 0.031 14.7 3.2 0.081 13.3 3.2 1.7 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP ResIII PF04851.15 KOO22134.1 - 0.032 14.2 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Pep_deformylase PF01327.21 KOO22135.1 - 1.8e-49 167.4 0.0 2.2e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 Polypeptide deformylase Flu_M1_C PF08289.11 KOO22136.1 - 0.15 12.3 0.2 0.26 11.5 0.2 1.3 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Aminotran_3 PF00202.21 KOO22136.1 - 0.33 9.5 2.5 0.46 9.1 2.5 1.1 1 0 0 1 1 1 0 Aminotransferase class-III Glyco_hydro_76 PF03663.14 KOO22137.1 - 7.4e-11 42.2 19.0 2.1e-08 34.1 19.0 3.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Somatomedin_B PF01033.17 KOO22137.1 - 0.00076 19.8 4.7 0.00076 19.8 4.7 3.0 2 1 0 2 2 2 1 Somatomedin B domain WD40 PF00400.32 KOO22138.1 - 3.6e-50 166.8 14.0 4.5e-06 27.3 0.1 10.2 10 0 0 10 10 10 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO22138.1 - 2.9e-17 62.8 2.1 0.0016 18.7 0.1 8.0 3 2 6 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 KOO22138.1 - 6.1e-15 55.5 0.9 1.6e-14 54.1 0.9 1.7 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.8 KOO22138.1 - 9.5e-06 24.5 1.6 0.28 9.8 0.0 4.7 4 1 0 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 KOO22138.1 - 6e-05 22.5 0.0 1.1 8.5 0.0 3.4 3 0 0 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 KOO22138.1 - 7.3e-05 21.9 0.7 0.44 9.5 0.0 4.8 3 2 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 KOO22138.1 - 0.0011 18.0 10.7 0.022 13.7 0.1 4.5 4 1 1 5 5 5 2 Partner and localizer of BRCA2 WD40 domain ELYS-bb PF16687.5 KOO22138.1 - 0.037 12.6 0.0 0.19 10.3 0.0 2.0 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin Hira PF07569.11 KOO22138.1 - 0.11 12.2 0.2 4.4 7.0 0.0 3.0 3 0 0 3 3 3 0 TUP1-like enhancer of split Tub PF01167.18 KOO22139.1 - 0.0032 17.2 0.0 0.6 9.8 0.0 2.2 2 0 0 2 2 2 2 Tub family KOW PF00467.29 KOO22139.1 - 0.027 14.4 0.1 0.074 13.0 0.1 1.8 1 0 0 1 1 1 0 KOW motif DUF3912 PF13051.6 KOO22139.1 - 0.028 14.7 0.0 0.057 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3912) NYN PF01936.18 KOO22140.1 - 2.3e-16 60.6 0.0 4.8e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 NYN domain Pkinase PF00069.25 KOO22141.1 - 1.5e-11 44.2 0.0 2.6e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22141.1 - 1.8e-07 30.7 0.0 4.5e-07 29.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO22141.1 - 0.0012 17.7 0.0 0.0023 16.8 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase IQ PF00612.27 KOO22143.1 - 8e-10 37.6 11.0 0.03 14.1 0.5 4.6 4 0 0 4 4 4 3 IQ calmodulin-binding motif HEAT_2 PF13646.6 KOO22143.1 - 1.4e-06 28.6 5.9 0.00066 20.0 0.1 2.5 1 1 1 2 2 2 2 HEAT repeats Arm PF00514.23 KOO22143.1 - 6.7e-05 22.8 3.2 0.00078 19.4 0.4 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO22143.1 - 0.0002 21.8 1.1 0.00098 19.6 0.3 2.6 1 1 1 2 2 2 1 HEAT-like repeat HEAT PF02985.22 KOO22143.1 - 0.0043 17.2 0.1 0.02 15.1 0.1 2.3 1 0 0 1 1 1 1 HEAT repeat IFRD PF05004.13 KOO22143.1 - 0.02 14.0 0.8 0.04 13.0 0.8 1.5 1 1 0 1 1 1 0 Interferon-related developmental regulator (IFRD) Peptidase_S10 PF00450.22 KOO22145.1 - 2.6e-81 274.2 0.0 3e-81 274.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Glycos_transf_1 PF00534.20 KOO22146.1 - 0.0094 15.5 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOO22146.1 - 0.13 12.7 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 LCIB_C_CA PF18599.1 KOO22147.1 - 1.4e-56 191.3 0.0 1.6e-56 191.1 0.0 1.0 1 0 0 1 1 1 1 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Cupin_4 PF08007.12 KOO22150.1 - 2.6e-25 89.6 0.0 3e-25 89.4 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 KOO22150.1 - 0.00014 21.6 0.0 0.0012 18.6 0.0 1.9 1 1 0 1 1 1 1 Cupin-like domain Sulfotransfer_3 PF13469.6 KOO22151.1 - 0.00066 20.1 0.1 0.034 14.5 0.0 2.4 1 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO22151.1 - 0.016 14.7 0.0 0.032 13.7 0.0 1.4 1 1 0 1 1 1 0 Sulfotransferase domain HCV_capsid PF01543.17 KOO22151.1 - 0.12 12.6 0.3 0.12 12.6 0.3 1.9 2 0 0 2 2 2 0 Hepatitis C virus capsid protein Abhydrolase_5 PF12695.7 KOO22152.1 - 1.9e-07 31.0 0.0 4.9e-07 29.6 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO22152.1 - 3.2e-05 23.3 0.0 5.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 KOO22152.1 - 0.0053 16.5 0.0 0.0092 15.7 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 KOO22152.1 - 0.022 15.4 0.7 0.022 15.4 0.7 2.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOO22152.1 - 0.032 13.7 0.1 0.064 12.7 0.1 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ion_trans_2 PF07885.16 KOO22153.1 - 3.7e-24 84.5 10.1 5.1e-14 52.0 2.8 3.7 4 0 0 4 4 4 2 Ion channel Sgf11 PF08209.11 KOO22153.1 - 4.1e-10 39.0 0.3 9.8e-10 37.8 0.3 1.7 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) Ion_trans PF00520.31 KOO22153.1 - 8.4e-07 28.5 11.8 0.033 13.4 0.1 3.2 3 0 0 3 3 3 3 Ion transport protein EF-hand_1 PF00036.32 KOO22153.1 - 0.033 13.7 0.3 0.033 13.7 0.3 3.4 3 0 0 3 3 3 0 EF hand EF-hand_6 PF13405.6 KOO22153.1 - 0.64 10.1 7.8 0.16 12.0 0.3 2.9 3 0 0 3 3 3 0 EF-hand domain OSCP PF00213.18 KOO22154.1 - 1.2e-39 136.2 1.9 1.5e-39 135.9 1.9 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit SET PF00856.28 KOO22155.1 - 2.6e-08 34.4 0.1 5e-08 33.5 0.0 1.6 2 0 0 2 2 2 1 SET domain MPC PF03650.13 KOO22156.1 - 1.1e-37 128.5 1.0 7.2e-19 68.0 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial pyruvate carriers Ank_2 PF12796.7 KOO22160.1 - 5.9e-18 65.2 4.8 6.6e-11 42.7 0.3 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO22160.1 - 6.3e-15 55.1 5.6 2.2e-06 27.8 0.3 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO22160.1 - 6e-14 52.2 1.1 5.9e-06 26.7 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22160.1 - 7.2e-11 41.3 3.2 0.047 14.2 0.0 5.7 5 0 0 5 5 5 2 Ankyrin repeat TPR_12 PF13424.6 KOO22160.1 - 8e-11 42.1 2.5 8e-11 42.1 2.5 6.7 4 1 4 8 8 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO22160.1 - 1.9e-09 37.1 1.1 6.2e-08 32.3 0.1 6.4 7 1 0 7 7 7 2 Tetratricopeptide repeat Ank PF00023.30 KOO22160.1 - 1.9e-09 37.5 18.7 0.0016 18.8 1.1 5.7 4 1 1 5 5 5 3 Ankyrin repeat TPR_1 PF00515.28 KOO22160.1 - 2.3e-07 30.4 4.7 0.0054 16.5 1.5 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat PDZ_6 PF17820.1 KOO22160.1 - 1.9e-05 24.4 0.2 7.9e-05 22.4 0.2 2.1 1 0 0 1 1 1 1 PDZ domain TPR_2 PF07719.17 KOO22160.1 - 0.0024 17.9 3.3 0.0024 17.9 3.3 5.3 5 1 1 6 6 4 2 Tetratricopeptide repeat PDZ PF00595.24 KOO22160.1 - 0.0032 17.8 0.1 0.0081 16.5 0.1 1.7 1 0 0 1 1 1 1 PDZ domain TPR_17 PF13431.6 KOO22160.1 - 0.018 15.4 0.0 0.1 13.1 0.0 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat PI3K_P85_iSH2 PF16454.5 KOO22160.1 - 0.036 13.7 1.6 0.44 10.1 1.3 2.5 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TPR_7 PF13176.6 KOO22160.1 - 0.055 13.5 6.0 0.52 10.5 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat PDZ_2 PF13180.6 KOO22160.1 - 0.13 12.6 0.0 0.36 11.2 0.0 1.7 1 0 0 1 1 1 0 PDZ domain DUF4061 PF13270.6 KOO22161.1 - 0.13 12.6 6.1 0.34 11.2 5.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4061) TFIIA PF03153.13 KOO22161.1 - 0.44 10.5 20.7 0.56 10.1 20.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Asp-B-Hydro_N PF05279.11 KOO22161.1 - 1.5 8.8 14.7 2.2 8.3 14.7 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Neur_chan_LBD PF02931.23 KOO22163.1 - 2.4e-08 33.7 0.0 2.9e-07 30.2 0.0 2.5 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KOO22163.1 - 0.0093 16.0 4.4 0.014 15.5 4.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region PARG_cat PF05028.14 KOO22164.1 - 6.6e-76 255.8 0.0 8.7e-76 255.4 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Mito_carr PF00153.27 KOO22165.1 - 3.6e-45 151.8 5.4 6.3e-16 58.1 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Tub PF01167.18 KOO22166.1 - 7.2e-28 98.0 0.0 1e-27 97.5 0.0 1.1 1 0 0 1 1 1 1 Tub family Presenilin PF01080.17 KOO22168.1 - 2.8e-94 316.2 22.1 1e-64 218.8 6.1 2.0 1 1 1 2 2 2 2 Presenilin PH PF00169.29 KOO22170.1 - 4.8e-05 23.8 0.0 7.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 PH domain GSHPx PF00255.19 KOO22170.1 - 0.0061 16.1 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione peroxidase Mito_carr PF00153.27 KOO22172.1 - 3.7e-19 68.5 6.9 2.4e-05 24.2 0.1 3.5 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF812 PF05667.11 KOO22173.1 - 0.0016 17.5 0.3 0.0016 17.4 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Apolipo_F PF15148.6 KOO22173.1 - 0.013 15.0 2.3 0.018 14.6 2.3 1.1 1 0 0 1 1 1 0 Apolipoprotein F Atg14 PF10186.9 KOO22173.1 - 0.039 13.0 3.1 0.05 12.7 3.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HAUS6_N PF14661.6 KOO22173.1 - 0.059 12.9 5.2 0.082 12.5 5.2 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF3450 PF11932.8 KOO22173.1 - 0.18 11.1 7.4 0.25 10.6 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 KOO22173.1 - 0.4 11.2 10.6 0.56 10.7 10.6 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF3138 PF11336.8 KOO22173.1 - 0.42 9.2 2.9 0.54 8.8 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF5320 PF17253.2 KOO22173.1 - 0.46 11.6 5.3 0.21 12.7 1.0 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5320) DUF4140 PF13600.6 KOO22173.1 - 0.53 10.8 6.4 0.68 10.4 1.0 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) TMPIT PF07851.13 KOO22173.1 - 1.6 7.9 3.5 2.1 7.5 3.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF3006 PF11213.8 KOO22173.1 - 2 8.7 7.4 0.074 13.3 1.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3006) FUSC PF04632.12 KOO22173.1 - 5 5.5 5.2 6.4 5.2 5.2 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DivIC PF04977.15 KOO22173.1 - 5.9 6.7 8.2 0.97 9.2 2.8 2.1 2 0 0 2 2 2 0 Septum formation initiator FAD_binding_3 PF01494.19 KOO22174.1 - 4.2e-17 62.4 1.2 1.1e-09 38.1 0.0 3.0 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 KOO22174.1 - 6e-06 26.4 0.1 1.4e-05 25.2 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO22174.1 - 8.7e-05 21.8 0.1 0.00022 20.5 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 KOO22174.1 - 0.00056 19.2 0.1 0.002 17.4 0.0 1.7 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO22174.1 - 0.00057 19.6 0.1 0.00093 18.9 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 KOO22174.1 - 0.029 13.2 0.0 3.4 6.4 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 KOO22174.1 - 0.07 11.8 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein FAD_oxidored PF12831.7 KOO22174.1 - 0.085 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase SE PF08491.10 KOO22174.1 - 0.15 11.1 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase AlaDh_PNT_C PF01262.21 KOO22174.1 - 1.4 8.2 3.1 2 7.6 0.4 2.4 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain KxDL PF10241.9 KOO22175.1 - 0.0073 16.6 1.9 0.0073 16.6 1.9 1.8 1 1 1 2 2 2 1 Uncharacterized conserved protein APG6_N PF17675.1 KOO22175.1 - 0.0079 16.7 8.0 0.0079 16.7 8.0 1.5 1 1 0 1 1 1 1 Apg6 coiled-coil region DUF3086 PF11285.8 KOO22175.1 - 0.0095 15.1 1.5 0.01 15.0 1.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3086) DUF724 PF05266.14 KOO22175.1 - 0.012 15.4 5.3 0.015 15.2 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) GAS PF13851.6 KOO22175.1 - 0.028 13.8 12.2 1.4 8.2 1.3 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 KOO22175.1 - 0.031 13.2 10.0 0.036 12.9 10.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein YbfN PF13982.6 KOO22175.1 - 0.032 14.5 0.5 0.085 13.1 0.1 1.8 2 0 0 2 2 2 0 YbfN-like lipoprotein TPR_MLP1_2 PF07926.12 KOO22175.1 - 0.04 14.0 12.3 0.041 14.0 11.7 1.3 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Syntaxin-6_N PF09177.11 KOO22175.1 - 0.05 14.2 7.2 0.12 12.9 1.6 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF1664 PF07889.12 KOO22175.1 - 0.14 12.2 2.8 0.55 10.3 1.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SlyX PF04102.12 KOO22175.1 - 0.22 12.2 2.8 0.25 12.0 1.3 1.9 1 1 1 2 2 2 0 SlyX DUF2721 PF11026.8 KOO22175.1 - 0.36 10.7 1.2 0.46 10.4 1.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2721) CorA PF01544.18 KOO22175.1 - 0.6 9.4 4.8 0.76 9.0 4.8 1.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein FAM76 PF16046.5 KOO22175.1 - 1.2 8.5 6.5 1.8 7.9 6.5 1.4 1 1 0 1 1 1 0 FAM76 protein HAUS6_N PF14661.6 KOO22175.1 - 1.9 8.0 8.8 0.78 9.3 1.6 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus ZapB PF06005.12 KOO22175.1 - 2.8 8.5 10.4 8.6 6.9 10.4 2.0 1 1 0 1 1 1 0 Cell division protein ZapB UPF0242 PF06785.11 KOO22175.1 - 7 6.7 11.1 39 4.3 11.1 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HSP90 PF00183.18 KOO22176.1 - 1.7e-207 690.4 11.6 2e-207 690.2 11.6 1.0 1 0 0 1 1 1 1 Hsp90 protein ComK PF06338.11 KOO22176.1 - 0.032 13.9 0.0 0.15 11.7 0.0 2.2 2 0 0 2 2 2 0 ComK protein Cofac_haem_bdg PF04187.13 KOO22176.1 - 0.054 13.5 0.9 0.15 12.0 0.9 1.7 1 1 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN LOH1CR12 PF10158.9 KOO22176.1 - 0.12 12.4 0.1 0.36 10.9 0.1 1.8 1 0 0 1 1 1 0 Tumour suppressor protein TAF1_subA PF14929.6 KOO22176.1 - 0.48 9.8 3.6 0.49 9.8 0.3 2.3 2 1 0 2 2 2 0 TAF RNA Polymerase I subunit A Glu_cyclase_2 PF05096.12 KOO22177.1 - 6.1e-61 206.0 0.1 2.7e-34 118.7 0.0 2.1 2 0 0 2 2 2 2 Glutamine cyclotransferase Aminotran_3 PF00202.21 KOO22178.1 - 6.1e-112 374.2 0.0 8.6e-112 373.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DNA_ligase_A_N PF04675.14 KOO22179.1 - 8.9e-33 114.0 0.0 2.4e-32 112.6 0.0 1.7 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_M PF01068.21 KOO22179.1 - 3.9e-29 101.8 0.0 3.2e-26 92.2 0.0 2.5 1 1 1 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 KOO22179.1 - 1.8e-14 54.1 0.0 6.2e-14 52.4 0.0 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_3 PF18428.1 KOO22179.1 - 0.0043 17.1 0.1 0.014 15.5 0.1 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain SopD PF11047.8 KOO22179.1 - 0.013 14.7 0.1 0.019 14.1 0.1 1.2 1 0 0 1 1 1 0 Salmonella outer protein D BRCT PF00533.26 KOO22179.1 - 0.054 13.9 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain mRNA_cap_enzyme PF01331.19 KOO22179.1 - 0.067 13.0 0.1 0.37 10.6 0.0 2.3 3 0 0 3 3 3 0 mRNA capping enzyme, catalytic domain CLPTM1 PF05602.12 KOO22180.1 - 2.3e-89 300.4 0.0 3.2e-89 299.9 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 KOO22180.1 - 0.0094 15.7 0.5 0.17 11.6 0.0 2.5 2 0 0 2 2 2 1 PQ loop repeat Metallophos PF00149.28 KOO22181.1 - 2e-10 41.5 0.1 4.1e-10 40.5 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3157 PF11355.8 KOO22181.1 - 0.05 13.2 4.2 0.11 12.1 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3157) AAA PF00004.29 KOO22182.1 - 9.8e-15 55.2 0.0 1.6e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) EF-hand_6 PF13405.6 KOO22182.1 - 5.6e-06 25.9 0.1 2.4e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO22182.1 - 7.4e-06 25.2 0.4 2.2e-05 23.7 0.4 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO22182.1 - 1.1e-05 25.7 0.1 0.00016 22.0 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO22182.1 - 1.2e-05 24.5 0.3 0.0001 21.6 0.1 2.4 2 0 0 2 2 2 1 EF hand Mg_chelatase PF01078.21 KOO22182.1 - 3.7e-05 23.2 0.2 0.03 13.7 0.1 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 KOO22182.1 - 0.00014 22.1 0.0 0.039 14.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 KOO22182.1 - 0.00026 20.8 0.0 0.001 18.9 0.0 1.9 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO22182.1 - 0.00052 20.4 0.3 0.0017 18.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.26 KOO22182.1 - 0.0024 17.6 0.0 0.033 13.9 0.0 2.4 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_2 PF07724.14 KOO22182.1 - 0.0036 17.4 0.0 0.0067 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Viral_helicase1 PF01443.18 KOO22182.1 - 0.0049 16.7 0.0 0.0077 16.0 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 KOO22182.1 - 0.0066 16.5 0.0 0.017 15.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 KOO22182.1 - 0.014 14.6 0.0 0.17 11.1 0.0 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) APS_kinase PF01583.20 KOO22182.1 - 0.036 14.0 0.0 0.56 10.1 0.0 2.1 2 0 0 2 2 2 0 Adenylylsulphate kinase TsaE PF02367.17 KOO22182.1 - 0.062 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 KOO22182.1 - 0.075 13.6 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain EF-hand_8 PF13833.6 KOO22182.1 - 0.083 12.8 0.0 0.5 10.2 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair Zeta_toxin PF06414.12 KOO22182.1 - 0.091 12.0 0.1 0.44 9.8 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 KOO22182.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 NTPase DUF815 PF05673.13 KOO22182.1 - 0.18 11.0 0.0 4.2 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) EF-hand_1 PF00036.32 KOO22183.1 - 6.9e-21 72.2 15.5 2.8e-07 29.6 1.5 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO22183.1 - 1.7e-20 71.1 9.3 4.9e-07 29.2 0.3 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO22183.1 - 6e-20 69.8 9.1 1.4e-07 30.7 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO22183.1 - 3.3e-17 62.7 11.2 1.8e-08 34.7 0.2 2.8 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO22183.1 - 2.3e-13 49.8 13.5 2e-05 24.3 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain pair p25-alpha PF05517.12 KOO22183.1 - 0.0032 17.6 1.7 0.0032 17.6 1.7 2.3 2 1 0 2 2 2 1 p25-alpha EF-hand_10 PF14788.6 KOO22183.1 - 0.029 14.2 1.5 11 5.9 0.1 3.4 3 0 0 3 3 3 0 EF hand Caleosin PF05042.13 KOO22183.1 - 0.03 14.3 2.2 10 6.0 0.0 3.6 2 2 2 4 4 4 0 Caleosin related protein EF-hand_9 PF14658.6 KOO22183.1 - 0.04 14.3 0.0 0.35 11.2 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_14 PF17959.1 KOO22183.1 - 0.074 13.4 4.5 13 6.2 2.3 3.5 2 1 0 2 2 2 0 EF-hand domain DUF3037 PF11236.8 KOO22183.1 - 3.1 8.3 6.3 52 4.3 6.3 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3037) Hydrolase PF00702.26 KOO22184.1 - 5.7e-12 46.4 10.7 2.2e-05 24.9 0.0 3.8 4 0 0 4 4 4 3 haloacid dehalogenase-like hydrolase GPHR_N PF12537.8 KOO22184.1 - 0.15 12.2 0.1 0.44 10.7 0.1 1.9 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal DUF4229 PF14012.6 KOO22184.1 - 0.19 11.8 2.1 4 7.6 0.4 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) E1-E2_ATPase PF00122.20 KOO22184.1 - 0.77 9.3 8.6 0.032 13.8 0.5 2.8 3 0 0 3 3 3 0 E1-E2 ATPase DUF2909 PF11137.8 KOO22184.1 - 7.3 6.6 7.1 6.2 6.8 1.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2909) CPSase_L_D2 PF02786.17 KOO22185.1 - 6.7e-104 346.0 0.3 1.2e-78 263.5 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 KOO22185.1 - 3.4e-48 162.7 0.0 6.8e-48 161.7 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 KOO22185.1 - 8.9e-41 139.8 0.0 4.4e-40 137.5 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 KOO22185.1 - 1.1e-36 125.9 0.1 2.9e-36 124.5 0.1 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 KOO22185.1 - 4.6e-15 55.6 0.1 3.3e-09 36.5 0.1 2.7 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 KOO22185.1 - 1e-12 48.1 0.0 3.9e-12 46.2 0.0 2.1 2 0 0 2 2 2 1 MGS-like domain ATPgrasp_Ter PF15632.6 KOO22185.1 - 2.5e-12 46.7 0.2 6.8e-05 22.6 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 KOO22185.1 - 6.1e-12 45.5 0.3 5.4e-05 22.8 0.0 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 KOO22185.1 - 1.6e-06 28.2 0.5 0.00083 19.4 0.2 2.5 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 KOO22185.1 - 0.00027 20.8 2.0 0.0073 16.1 0.3 3.0 2 1 0 2 2 2 1 Peptidase C26 Nif11 PF07862.11 KOO22185.1 - 0.0061 16.8 1.0 0.51 10.7 0.0 3.9 4 0 0 4 4 4 1 Nif11 domain GARS_A PF01071.19 KOO22185.1 - 0.028 14.2 0.2 0.26 11.0 0.1 2.4 2 1 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DOCK_N PF16172.5 KOO22185.1 - 0.19 10.6 0.0 0.34 9.8 0.0 1.3 1 0 0 1 1 1 0 DOCK N-terminus GPS PF01825.21 KOO22186.1 - 1.5e-07 31.8 7.7 3.2e-07 30.8 7.7 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif cNMP_binding PF00027.29 KOO22187.1 - 8.2e-10 38.6 0.2 1.6e-08 34.5 0.2 2.5 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain AAA_16 PF13191.6 KOO22187.1 - 4.1e-09 37.0 0.2 1.1e-08 35.7 0.2 1.7 1 0 0 1 1 1 1 AAA ATPase domain Guanylate_cyc PF00211.20 KOO22187.1 - 2.3e-06 27.3 0.0 4.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain IstB_IS21 PF01695.17 KOO22187.1 - 0.0001 22.1 0.1 0.00028 20.7 0.1 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 KOO22187.1 - 0.0018 17.5 0.1 0.003 16.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 KOO22187.1 - 0.002 18.4 0.4 0.0056 16.9 0.4 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO22187.1 - 0.0091 16.0 0.0 0.022 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 KOO22187.1 - 0.021 14.6 0.1 0.052 13.3 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO22187.1 - 0.026 14.8 0.0 0.13 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 KOO22187.1 - 0.039 13.3 0.1 0.082 12.2 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_33 PF13671.6 KOO22187.1 - 0.092 12.9 0.9 0.28 11.3 0.3 2.2 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KOO22187.1 - 0.094 13.2 0.0 0.4 11.2 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Activator-TraM PF11657.8 KOO22187.1 - 0.11 12.4 0.4 0.25 11.2 0.4 1.6 1 0 0 1 1 1 0 Transcriptional activator TraM AAA_8 PF12780.7 KOO22187.1 - 0.14 11.4 0.1 0.25 10.6 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 SMC_N PF02463.19 KOO22187.1 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain PKD_channel PF08016.12 KOO22189.1 - 2.4e-29 102.3 13.8 2.4e-29 102.3 13.8 1.5 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 KOO22189.1 - 5.6e-12 45.4 16.1 7.9e-12 44.9 16.1 1.2 1 0 0 1 1 1 1 Ion transport protein Anoctamin PF04547.12 KOO22190.1 - 2.2e-99 333.4 10.7 2.6e-99 333.1 10.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KOO22190.1 - 4.3e-06 26.6 0.0 0.00037 20.3 0.0 2.3 1 1 1 2 2 2 2 Dimerisation domain of Ca+-activated chloride-channel, anoctamin YhhN PF07947.14 KOO22190.1 - 2.8 7.5 7.0 0.27 10.8 1.2 2.2 2 0 0 2 2 2 0 YhhN family TPT PF03151.16 KOO22191.1 - 4.1e-20 72.3 13.9 6.2e-20 71.7 13.9 1.3 1 0 0 1 1 1 1 Triose-phosphate Transporter family Metallophos PF00149.28 KOO22192.1 - 4.6e-26 92.6 0.1 4.7e-25 89.3 0.1 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase TAD2 PF18521.1 KOO22192.1 - 0.085 12.9 0.3 0.25 11.4 0.3 1.8 1 0 0 1 1 1 0 Transactivation domain 2 PAS_9 PF13426.7 KOO22194.1 - 1.1e-08 35.2 0.0 2.3e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 KOO22194.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.7 1 0 0 1 1 1 0 PAS fold PAS_8 PF13188.7 KOO22194.1 - 0.044 13.8 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 PAS domain Na_Ca_ex PF01699.24 KOO22195.1 - 1.7e-30 106.0 29.3 4.2e-18 65.7 7.2 2.5 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DNA_pol_A PF00476.20 KOO22196.1 - 1.5e-74 251.4 0.0 2.1e-73 247.5 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 KOO22196.1 - 4.2e-09 36.4 0.0 9e-09 35.3 0.0 1.6 1 1 0 1 1 1 1 3'-5' exonuclease Ank_2 PF12796.7 KOO22198.1 - 9.5e-25 87.0 0.0 4.4e-11 43.2 0.0 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO22198.1 - 2.1e-17 62.9 2.1 2.2e-11 43.8 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO22198.1 - 2.7e-16 59.2 0.3 0.00022 21.6 0.1 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KOO22198.1 - 2.6e-15 56.6 0.0 2.7e-10 40.6 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22198.1 - 5.6e-14 50.9 0.2 0.0039 17.6 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat DUF3263 PF11662.8 KOO22198.1 - 0.025 14.4 0.1 0.046 13.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) TauE PF01925.19 KOO22199.1 - 5.1e-17 62.3 38.6 7.4e-17 61.8 31.7 2.7 3 1 0 3 3 3 1 Sulfite exporter TauE/SafE AOX PF01786.17 KOO22199.1 - 0.41 10.2 2.0 5.7 6.5 0.1 2.4 2 0 0 2 2 2 0 Alternative oxidase Glyco_transf_90 PF05686.12 KOO22200.1 - 1.4e-32 113.1 0.0 6.1e-32 111.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 KOO22200.1 - 0.011 16.1 0.0 0.039 14.3 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferases group 1 Ribosomal_S7 PF00177.21 KOO22201.1 - 6.4e-27 94.0 0.0 8.1e-27 93.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF4231 PF14015.6 KOO22202.1 - 0.00029 21.3 0.0 0.0078 16.7 0.0 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF4231) SLATT_1 PF18181.1 KOO22202.1 - 0.0074 16.2 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain 1 Rieske PF00355.26 KOO22203.1 - 3e-14 52.7 0.1 4.6e-14 52.1 0.1 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain CytB6-F_Fe-S PF08802.10 KOO22203.1 - 1.3e-12 47.5 0.6 1.3e-12 47.5 0.6 2.1 3 0 0 3 3 3 1 Cytochrome B6-F complex Fe-S subunit Mcp5_PH PF12814.7 KOO22204.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology 2-Hacid_dh_C PF02826.19 KOO22205.1 - 3.5e-37 127.5 0.0 5e-37 127.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KOO22205.1 - 0.00057 20.4 0.7 0.0028 18.2 0.3 2.5 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh PF00389.30 KOO22205.1 - 0.092 12.4 0.0 0.12 12.1 0.0 1.2 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain SepQ PF06622.11 KOO22205.1 - 0.13 11.4 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 SepQ protein Aminotran_3 PF00202.21 KOO22206.1 - 1.9e-81 273.8 0.0 2.3e-81 273.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 KOO22206.1 - 3e-06 26.7 0.0 4.8e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase SelR PF01641.18 KOO22207.1 - 3.3e-42 143.4 0.2 4.9e-42 142.8 0.2 1.3 1 0 0 1 1 1 1 SelR domain Methyltransf_16 PF10294.9 KOO22207.1 - 2.3e-12 47.0 0.0 3.4e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 KOO22207.1 - 0.0091 15.6 0.1 0.018 14.6 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.16 KOO22207.1 - 0.011 15.5 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein GidB PF02527.15 KOO22207.1 - 0.083 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G ABC_transp_aux PF09822.9 KOO22208.1 - 3e-05 23.6 0.0 4.1e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DDOST_48kD PF03345.14 KOO22208.1 - 0.00049 19.0 0.0 0.00088 18.2 0.0 1.3 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta DUF4159 PF13709.6 KOO22208.1 - 0.011 15.2 0.0 0.027 13.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4159) SHIPPO-rpt PF07004.12 KOO22209.1 - 8.8e-09 35.9 11.2 0.58 11.2 0.1 5.8 5 0 0 5 5 5 5 Sperm-tail PG-rich repeat Guanylate_cyc_2 PF09778.9 KOO22210.1 - 8.6e-49 165.8 0.0 1.1e-48 165.4 0.0 1.1 1 0 0 1 1 1 1 Guanylylate cyclase Peptidase_C39_2 PF13529.6 KOO22210.1 - 5.7e-08 33.4 0.1 4.7e-07 30.4 0.1 2.2 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 KOO22210.1 - 9.2e-05 22.5 0.3 0.047 13.7 0.3 3.1 1 1 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 Peptidase_C39 PF03412.15 KOO22210.1 - 0.00019 21.2 0.0 0.061 13.1 0.0 2.3 2 0 0 2 2 2 2 Peptidase C39 family DAO PF01266.24 KOO22210.1 - 0.00028 20.6 0.0 0.00033 20.3 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF3335 PF11814.8 KOO22210.1 - 0.01 15.3 0.3 8.9 5.7 0.1 3.0 3 0 0 3 3 3 0 Peptidase_C39 like family Amino_oxidase PF01593.24 KOO22211.1 - 2e-64 218.5 2.1 4e-64 217.6 2.1 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 KOO22211.1 - 2.1e-08 34.3 0.8 0.00097 19.1 0.1 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 KOO22211.1 - 6.4e-08 32.7 0.4 1.9e-07 31.2 0.4 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOO22211.1 - 0.0004 19.7 0.1 0.00075 18.8 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 KOO22211.1 - 0.0013 18.0 0.5 0.15 11.3 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO22211.1 - 0.0016 17.8 0.3 0.28 10.4 0.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO22211.1 - 0.0017 17.1 0.1 1.1 7.9 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein DAO PF01266.24 KOO22211.1 - 0.017 14.7 6.6 0.058 13.0 6.6 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase RMI2 PF16100.5 KOO22211.1 - 0.018 14.8 0.2 0.052 13.4 0.1 1.8 2 0 0 2 2 2 0 RecQ-mediated genome instability protein 2 AlaDh_PNT_C PF01262.21 KOO22211.1 - 0.043 13.1 0.2 0.083 12.2 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 KOO22211.1 - 0.12 12.9 0.2 1.1 9.9 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FLgD_tudor PF13861.6 KOO22211.1 - 1.9 8.8 4.9 1.5 9.2 2.0 2.4 2 1 0 2 2 2 0 FlgD Tudor-like domain AAA_34 PF13872.6 KOO22212.1 - 1.6e-108 362.2 0.0 2.8e-108 361.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 KOO22212.1 - 5.8e-99 331.2 0.1 2.1e-98 329.3 0.0 2.0 2 0 0 2 2 2 1 C-terminal domain on Strawberry notch homologue Helicase_C PF00271.31 KOO22212.1 - 0.007 16.7 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Carbpep_Y_N PF05388.11 KOO22212.1 - 0.0093 16.5 0.2 0.033 14.7 0.0 2.0 2 0 0 2 2 2 1 Carboxypeptidase Y pro-peptide Peptidase_S37 PF05576.11 KOO22212.1 - 0.036 12.8 0.1 1.1 7.9 0.0 2.1 2 0 0 2 2 2 0 PS-10 peptidase S37 BAF1_ABF1 PF04684.13 KOO22212.1 - 0.58 9.2 15.2 0.06 12.4 2.1 2.4 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Metallophos PF00149.28 KOO22213.1 - 5.4e-09 36.8 0.0 3.2e-08 34.3 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase WD40 PF00400.32 KOO22214.1 - 7.9e-13 48.7 0.1 0.026 15.4 0.1 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO22214.1 - 1.1e-08 35.3 0.0 0.21 11.9 0.0 5.2 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 KOO22214.1 - 0.0078 14.8 0.0 0.18 10.3 0.0 2.2 2 0 0 2 2 2 1 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 KOO22214.1 - 0.017 14.1 0.2 5.8 5.8 0.1 3.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pox_Ag35 PF03286.14 KOO22214.1 - 0.13 12.0 3.4 0.24 11.2 3.4 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Aldo_ket_red PF00248.21 KOO22215.1 - 1.4e-25 90.2 0.0 3.6e-24 85.5 0.0 2.2 1 1 0 1 1 1 1 Aldo/keto reductase family VIT PF08487.10 KOO22216.1 - 4.1e-06 27.0 0.0 6.8e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 KOO22216.1 - 4.4e-05 23.5 0.0 0.00012 22.0 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Phage_integrase PF00589.22 KOO22218.1 - 0.059 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Phage integrase family RCC1 PF00415.18 KOO22219.1 - 2.5e-69 229.7 11.5 1.9e-10 41.2 0.1 8.2 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO22219.1 - 2.2e-39 132.5 29.2 3.2e-08 33.2 0.2 8.3 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat IBN_N PF03810.19 KOO22220.1 - 1.2e-09 37.9 1.8 4.6e-09 36.1 1.3 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT PF02985.22 KOO22220.1 - 0.00018 21.5 23.7 1.1 9.7 0.0 11.4 14 0 0 14 14 14 2 HEAT repeat CheX PF13690.6 KOO22220.1 - 0.013 15.6 0.0 0.061 13.5 0.0 2.1 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX HEAT_EZ PF13513.6 KOO22220.1 - 0.27 11.8 19.3 1.1 9.8 0.1 7.1 8 0 0 8 8 8 0 HEAT-like repeat DRIM PF07539.12 KOO22220.1 - 1.2 7.3 6.0 1.9 6.7 0.1 3.8 4 2 2 6 6 6 0 Down-regulated in metastasis HEAT_2 PF13646.6 KOO22220.1 - 2.4 8.6 21.2 0.98 9.8 0.5 6.5 5 2 2 8 8 8 0 HEAT repeats CLASP_N PF12348.8 KOO22220.1 - 2.8 7.4 5.5 5.6 6.5 0.0 3.6 5 0 0 5 5 5 0 CLASP N terminal OTU PF02338.19 KOO22221.1 - 0.00012 22.6 0.0 0.00031 21.3 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease DIOX_N PF14226.6 KOO22223.1 - 2.2e-06 28.4 0.0 2.1e-05 25.2 0.0 2.3 2 1 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 KOO22223.1 - 0.015 15.8 0.0 0.023 15.2 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Glyco_transf_90 PF05686.12 KOO22224.1 - 4.9e-27 94.9 0.0 1.9e-16 60.0 0.0 2.7 2 1 0 3 3 3 2 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 KOO22224.1 - 0.077 13.4 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 E1_4HB PF16191.5 KOO22226.1 - 0.021 15.0 0.0 0.033 14.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 four-helix bundle TetR_C_11 PF16859.5 KOO22226.1 - 0.043 14.1 0.1 0.05 13.9 0.1 1.1 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain AP2 PF00847.20 KOO22228.1 - 2e-17 63.1 38.7 0.035 14.3 0.0 12.6 12 0 0 12 12 12 7 AP2 domain zf-RING_2 PF13639.6 KOO22228.1 - 1.1e-05 25.6 5.8 2.5e-05 24.5 5.8 1.6 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 KOO22228.1 - 0.00063 19.9 3.8 0.0028 17.8 2.5 3.0 2 0 0 2 2 2 1 FANCL C-terminal domain zf-rbx1 PF12678.7 KOO22228.1 - 0.0038 17.5 4.5 0.0085 16.4 4.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KOO22228.1 - 0.16 11.9 5.6 0.32 11.0 5.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain RINGv PF12906.7 KOO22228.1 - 2.8 8.1 5.6 5.3 7.2 5.6 1.5 1 0 0 1 1 1 0 RING-variant domain Transposase_20 PF02371.16 KOO22228.1 - 3.5 8.0 11.7 17 5.8 0.1 6.1 7 0 0 7 7 7 0 Transposase IS116/IS110/IS902 family zf-C3HC4_3 PF13920.6 KOO22228.1 - 5.9 6.8 8.6 30 4.6 8.6 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Amnionless PF14828.6 KOO22231.1 - 0.0093 14.8 0.2 0.012 14.5 0.2 1.0 1 0 0 1 1 1 1 Amnionless FlgN PF05130.12 KOO22231.1 - 0.016 15.7 0.0 0.023 15.2 0.0 1.2 1 0 0 1 1 1 0 FlgN protein SQS_PSY PF00494.19 KOO22231.1 - 0.021 14.3 1.0 0.029 13.9 0.1 1.6 2 0 0 2 2 2 0 Squalene/phytoene synthase DUF3369 PF11849.8 KOO22231.1 - 0.063 13.5 1.5 20 5.3 0.1 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF3369) DUF883 PF05957.13 KOO22231.1 - 0.064 13.9 5.8 0.2 12.3 5.8 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.18 KOO22231.1 - 0.086 12.7 4.7 0.13 12.1 4.7 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DegS PF05384.11 KOO22231.1 - 0.088 12.3 2.5 0.12 11.9 2.5 1.1 1 0 0 1 1 1 0 Sensor protein DegS Phasin_2 PF09361.10 KOO22231.1 - 0.088 13.1 0.2 2.6 8.4 0.1 2.1 1 1 1 2 2 2 0 Phasin protein Vps53_N PF04100.12 KOO22231.1 - 0.098 11.6 0.8 0.12 11.4 0.8 1.0 1 0 0 1 1 1 0 Vps53-like, N-terminal Virul_Fac PF10139.9 KOO22231.1 - 0.18 10.0 0.2 0.24 9.5 0.2 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor FAM25 PF15825.5 KOO22231.1 - 9 6.7 11.8 11 6.5 1.2 2.4 1 1 1 2 2 2 0 FAM25 family IQ PF00612.27 KOO22232.1 - 3.5e-05 23.2 8.2 0.047 13.5 0.5 3.4 3 0 0 3 3 3 3 IQ calmodulin-binding motif TPMT PF05724.11 KOO22233.1 - 4.3e-37 127.9 0.0 9.9e-19 67.9 0.0 2.0 2 0 0 2 2 2 2 Thiopurine S-methyltransferase (TPMT) Methyltransf_23 PF13489.6 KOO22233.1 - 0.0016 18.3 0.0 0.04 13.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22233.1 - 0.023 15.4 0.0 10 6.9 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 KOO22233.1 - 0.086 13.5 0.0 5.3 7.8 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain DUF2300 PF10062.9 KOO22233.1 - 0.34 11.0 2.5 0.86 9.7 0.1 2.5 3 0 0 3 3 3 0 Predicted secreted protein (DUF2300) SelR PF01641.18 KOO22234.1 - 2.1e-47 160.2 0.2 2.6e-47 159.9 0.2 1.1 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 KOO22234.1 - 0.011 15.4 0.7 1.4 8.7 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 KOO22234.1 - 0.036 14.1 0.3 0.12 12.4 0.3 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-Mss51 PF13824.6 KOO22234.1 - 0.097 12.8 2.6 0.38 10.9 0.6 2.8 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 DUF2318 PF10080.9 KOO22234.1 - 0.14 12.3 0.7 1.4 9.1 0.0 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) TF_Zn_Ribbon PF08271.12 KOO22234.1 - 0.14 11.7 1.8 3.1 7.4 0.1 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Ribosomal_L37e PF01907.19 KOO22234.1 - 0.17 12.1 2.3 0.67 10.2 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L37e Yippee-Mis18 PF03226.14 KOO22234.1 - 0.18 12.1 0.5 0.72 10.1 0.5 2.0 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-ribbon_3 PF13248.6 KOO22234.1 - 7.9 6.0 7.5 18 4.9 0.6 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zf-RanBP PF00641.18 KOO22235.1 - 2.2e-08 33.2 1.2 2.2e-08 33.2 1.2 1.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others PKcGMP_CC PF16808.5 KOO22235.1 - 0.00039 20.2 14.4 0.038 13.9 2.9 3.3 3 0 0 3 3 3 2 Coiled-coil N-terminus of cGMP-dependent protein kinase ADH_N PF08240.12 KOO22235.1 - 0.074 12.9 0.2 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain GATA PF00320.27 KOO22235.1 - 2.1 8.0 8.0 13 5.5 2.3 2.5 2 0 0 2 2 2 0 GATA zinc finger DUF16 PF01519.16 KOO22235.1 - 4 8.0 16.2 17 6.0 1.2 3.1 2 1 0 2 2 2 0 Protein of unknown function DUF16 Spc29 PF17082.5 KOO22235.1 - 5.8 6.7 13.2 2.5 7.9 3.3 2.6 2 1 0 2 2 2 0 Spindle Pole Component 29 NYD-SP28 PF14772.6 KOO22235.1 - 9.8 6.3 25.7 1.2 9.2 2.0 4.0 2 1 1 3 3 3 0 Sperm tail NHL PF01436.21 KOO22236.1 - 2.2e-21 74.7 0.0 0.00017 21.5 0.0 5.5 5 0 0 5 5 5 4 NHL repeat Arylesterase PF01731.20 KOO22236.1 - 3.4e-08 33.6 0.0 1.6 9.0 0.0 5.1 5 0 0 5 5 5 2 Arylesterase SGL PF08450.12 KOO22236.1 - 5.1e-08 32.8 0.2 0.17 11.4 0.0 4.3 1 1 3 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region EF-hand_6 PF13405.6 KOO22236.1 - 5.3e-06 25.9 0.1 0.0005 19.8 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO22236.1 - 5.2e-05 23.6 0.0 9.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair Lactonase PF10282.9 KOO22236.1 - 9.2e-05 21.8 0.7 0.46 9.7 0.1 2.8 1 1 1 2 2 2 2 Lactonase, 7-bladed beta-propeller EF-hand_1 PF00036.32 KOO22236.1 - 9.9e-05 21.6 0.0 0.00048 19.5 0.0 2.1 2 0 0 2 2 2 1 EF hand Str_synth PF03088.16 KOO22236.1 - 0.00028 20.9 0.0 12 6.1 0.0 4.8 6 0 0 6 6 5 1 Strictosidine synthase EF-hand_8 PF13833.6 KOO22236.1 - 0.003 17.3 0.0 0.007 16.2 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO22236.1 - 0.009 15.5 0.0 0.024 14.1 0.0 1.7 1 0 0 1 1 1 1 EF hand DUF839 PF05787.13 KOO22236.1 - 0.015 14.5 0.6 3.6 6.6 0.0 3.1 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF839) PD40 PF07676.12 KOO22236.1 - 0.14 12.1 0.2 1.2 9.1 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Adeno_E3_CR2 PF02439.15 KOO22237.1 - 0.18 11.6 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Mitoc_L55 PF09776.9 KOO22238.1 - 1.4e-07 31.3 0.1 9.5 6.0 0.0 7.8 1 1 8 9 9 9 1 Mitochondrial ribosomal protein L55 Nrap_D5 PF17406.2 KOO22238.1 - 0.0061 16.3 0.0 4 7.2 0.0 2.7 2 1 0 2 2 2 2 Nrap protein PAP/OAS1-like domain 5 DUF1041 PF06292.17 KOO22238.1 - 0.032 14.6 0.0 1.7 9.1 0.0 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1041) C2 PF00168.30 KOO22239.1 - 3.7e-62 207.0 0.0 1.1e-13 51.3 0.0 7.2 7 0 0 7 7 7 7 C2 domain DOCK-C2 PF14429.6 KOO22239.1 - 0.0011 18.8 0.0 7.1 6.4 0.0 3.3 3 0 0 3 3 3 3 C2 domain in Dock180 and Zizimin proteins 2OG-FeII_Oxy_3 PF13640.6 KOO22240.1 - 4.7e-15 56.2 0.1 6.5e-15 55.8 0.1 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily LRR_5 PF13306.6 KOO22241.1 - 4.3e-98 324.2 7.7 2.2e-37 127.9 4.4 3.4 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) Pkinase PF00069.25 KOO22241.1 - 5.3e-28 98.1 0.0 1.5e-17 63.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Kelch_1 PF01344.25 KOO22241.1 - 1.2e-27 95.2 15.1 0.0015 18.1 0.0 8.7 8 0 0 8 8 8 8 Kelch motif Kelch_5 PF13854.6 KOO22241.1 - 4.8e-25 87.1 14.3 0.00098 19.1 0.0 8.7 8 0 0 8 8 8 6 Kelch motif Kelch_3 PF13415.6 KOO22241.1 - 1.7e-23 82.4 30.8 4e-07 30.2 0.1 8.9 9 0 0 9 9 9 6 Galactose oxidase, central domain Kelch_2 PF07646.15 KOO22241.1 - 8.4e-22 76.3 15.4 0.0035 17.3 0.0 8.2 8 0 0 8 8 8 7 Kelch motif Kelch_6 PF13964.6 KOO22241.1 - 9.1e-20 70.2 13.6 0.0015 18.8 0.0 8.6 7 1 1 8 8 8 6 Kelch motif Methyltr_RsmB-F PF01189.17 KOO22241.1 - 8.8e-18 64.7 0.0 4.3e-17 62.4 0.0 1.9 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Kelch_4 PF13418.6 KOO22241.1 - 2.7e-17 62.5 23.9 0.00011 22.1 0.0 7.9 7 0 0 7 7 7 6 Galactose oxidase, central domain LRR_8 PF13855.6 KOO22241.1 - 8.9e-16 57.4 0.0 0.043 13.6 0.0 7.6 1 1 9 10 10 10 4 Leucine rich repeat SAM_1 PF00536.30 KOO22241.1 - 2e-11 44.1 0.1 4.9e-11 42.9 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO22241.1 - 1.5e-08 34.6 0.1 3.7e-08 33.4 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_Tyr PF07714.17 KOO22241.1 - 4.7e-07 29.4 0.0 0.0085 15.4 0.0 2.4 3 0 0 3 3 3 2 Protein tyrosine kinase LRR_4 PF12799.7 KOO22241.1 - 1.4 9.5 8.4 4.6 7.8 0.0 5.6 8 1 1 9 9 5 0 Leucine Rich repeats (2 copies) Stevor PF17410.2 KOO22242.1 - 0.094 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Atg8 PF02991.16 KOO22243.1 - 3.7e-74 245.5 0.0 2.7e-37 127.1 0.0 2.3 2 1 0 2 2 2 2 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KOO22243.1 - 2.2e-09 37.6 0.0 0.0023 18.3 0.0 2.4 2 1 0 2 2 2 2 Ubiquitin-like autophagy protein Apg12 Il2rg PF15874.5 KOO22243.1 - 0.015 15.6 0.0 4.7 7.5 0.0 2.2 2 0 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain PRiA4_ORF3 PF07929.11 KOO22243.1 - 0.02 14.6 0.0 5.5 6.7 0.0 2.1 2 0 0 2 2 2 0 Plasmid pRiA4b ORF-3-like protein ABC_tran PF00005.27 KOO22245.1 - 1.1e-41 142.5 0.0 1.8e-20 73.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ECH_1 PF00378.20 KOO22245.1 - 2e-38 132.1 2.5 9.2e-32 110.3 0.0 4.2 4 0 0 4 4 4 3 Enoyl-CoA hydratase/isomerase AAA_21 PF13304.6 KOO22245.1 - 1.6e-19 70.8 0.1 7.6e-06 25.9 0.0 4.2 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ECH_2 PF16113.5 KOO22245.1 - 9.2e-17 61.5 0.0 2.1e-16 60.4 0.0 1.6 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Chal_sti_synt_N PF00195.19 KOO22245.1 - 1.8e-13 50.5 1.1 9.6e-13 48.1 0.4 2.2 2 0 0 2 2 2 1 Chalcone and stilbene synthases, N-terminal domain ABC_tran_Xtn PF12848.7 KOO22245.1 - 5.4e-13 48.8 6.2 1.1e-12 47.8 6.2 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOO22245.1 - 8.3e-12 45.0 0.0 0.11 11.9 0.0 4.4 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain Chal_sti_synt_C PF02797.15 KOO22245.1 - 1.1e-11 45.0 0.0 3.2e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain FAE1_CUT1_RppA PF08392.12 KOO22245.1 - 3.9e-11 42.8 0.0 9.4e-11 41.5 0.0 1.5 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 KOO22245.1 - 4.2e-09 36.5 0.2 1.6e-08 34.6 0.0 2.2 2 0 0 2 2 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal AAA_29 PF13555.6 KOO22245.1 - 1.4e-07 31.2 0.2 0.029 14.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.12 KOO22245.1 - 1.4e-06 28.4 0.0 0.0035 17.3 0.0 2.8 2 0 0 2 2 2 2 NACHT domain AAA_23 PF13476.6 KOO22245.1 - 4.3e-06 27.4 5.6 0.02 15.4 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 KOO22245.1 - 0.00014 22.3 1.0 0.47 10.8 0.0 3.3 3 0 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 KOO22245.1 - 0.00017 21.6 0.1 0.1 12.5 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA PF00004.29 KOO22245.1 - 0.0002 21.8 0.1 0.9 10.0 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KOO22245.1 - 0.00026 21.3 0.2 0.14 12.4 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOO22245.1 - 0.00037 21.0 0.1 1.7 9.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 KOO22245.1 - 0.00043 20.1 5.0 0.016 15.0 0.1 3.3 3 1 0 3 3 3 1 AAA domain AAA_15 PF13175.6 KOO22245.1 - 0.00059 19.7 0.1 0.89 9.2 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_27 PF13514.6 KOO22245.1 - 0.0016 18.1 0.1 0.34 10.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 KOO22245.1 - 0.0018 18.2 0.9 0.71 9.8 0.1 3.1 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_33 PF13671.6 KOO22245.1 - 0.0058 16.8 0.0 5.5 7.1 0.0 3.0 2 0 0 2 2 2 0 AAA domain DUF2791 PF10923.8 KOO22245.1 - 0.0073 15.2 0.1 0.013 14.4 0.1 1.3 1 0 0 1 1 1 1 P-loop Domain of unknown function (DUF2791) RNA_helicase PF00910.22 KOO22245.1 - 0.0088 16.4 0.0 6 7.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 KOO22245.1 - 0.0094 16.2 1.3 6.7 7.0 0.0 3.4 4 0 0 4 4 2 0 AAA domain DUF815 PF05673.13 KOO22245.1 - 0.0095 15.1 0.1 4.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) SRP54 PF00448.22 KOO22245.1 - 0.013 15.2 1.0 0.23 11.1 0.2 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain T2SSE PF00437.20 KOO22245.1 - 0.017 14.2 0.3 0.25 10.4 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein MMR_HSR1 PF01926.23 KOO22245.1 - 0.018 15.1 0.1 11 6.2 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase DAP3 PF10236.9 KOO22245.1 - 0.019 14.2 0.1 3 6.9 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_14 PF13173.6 KOO22245.1 - 0.033 14.2 0.0 13 5.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 KOO22245.1 - 0.053 13.8 0.0 2 8.7 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.6 KOO22245.1 - 0.065 13.7 0.9 3.7 8.0 0.1 2.8 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KOO22245.1 - 0.076 13.0 0.0 11 6.0 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 KOO22245.1 - 0.085 12.9 0.1 14 5.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) cobW PF02492.19 KOO22245.1 - 0.097 12.3 0.1 24 4.5 0.0 3.0 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.20 KOO22245.1 - 0.12 11.5 0.0 2.1 7.4 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit Arf PF00025.21 KOO22245.1 - 0.13 11.7 0.0 0.36 10.2 0.0 1.8 1 0 0 1 1 1 0 ADP-ribosylation factor family Viral_helicase1 PF01443.18 KOO22245.1 - 0.15 11.8 0.0 2.2 7.9 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_13 PF13166.6 KOO22245.1 - 0.19 10.3 0.4 13 4.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 KOO22245.1 - 0.22 11.4 0.1 24 4.8 0.0 2.6 2 0 0 2 2 2 0 NTPase ABC_ATPase PF09818.9 KOO22245.1 - 1.8 7.3 3.9 13 4.4 0.0 2.9 3 0 0 3 3 3 0 Predicted ATPase of the ABC class RhlB PF12300.8 KOO22247.1 - 0.009 16.2 0.4 0.009 16.2 0.4 1.9 2 0 0 2 2 2 1 ATP-dependent RNA helicase RhlB Strabismus PF06638.11 KOO22247.1 - 0.29 9.8 0.7 0.33 9.6 0.7 1.1 1 0 0 1 1 1 0 Strabismus protein Actin PF00022.19 KOO22248.1 - 3e-121 404.8 0.0 3.4e-121 404.7 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KOO22248.1 - 1.4e-05 24.1 0.1 0.00069 18.5 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 KOO22248.1 - 0.15 12.5 0.5 4.6 7.7 0.1 2.5 2 0 0 2 2 2 0 Cell division protein FtsA FTCD_C PF04961.12 KOO22248.1 - 8.7 6.1 6.0 4.2 7.1 3.2 1.7 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase RabGAP-TBC PF00566.18 KOO22249.1 - 2.7e-37 128.5 0.0 3.6e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain FAM47 PF14642.6 KOO22249.1 - 0.049 13.2 1.0 0.091 12.3 0.6 1.7 1 1 0 1 1 1 0 FAM47 family Peptidase_C92 PF05708.12 KOO22250.1 - 3e-06 27.4 0.0 0.0018 18.4 0.0 2.5 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family TIM PF00121.18 KOO22251.1 - 5.2e-65 219.2 0.0 6e-65 219.0 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Arm-DNA-bind_3 PF13356.6 KOO22251.1 - 0.014 15.8 0.0 0.024 15.0 0.0 1.3 1 0 0 1 1 1 0 Arm DNA-binding domain Pkinase PF00069.25 KOO22253.1 - 3.5e-32 111.8 0.0 1.3e-28 100.1 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22253.1 - 2.4e-15 56.5 0.0 4.5e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO22253.1 - 0.0042 16.5 2.1 0.037 13.4 2.1 2.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YukC PF10140.9 KOO22253.1 - 0.077 11.8 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Kinase-like PF14531.6 KOO22253.1 - 0.11 11.8 0.1 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Na_Ca_ex PF01699.24 KOO22255.1 - 3e-29 101.9 39.0 2.7e-15 56.6 16.3 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF5527 PF17665.1 KOO22255.1 - 0.61 9.6 0.0 0.61 9.6 0.0 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5527) Amino_oxidase PF01593.24 KOO22256.1 - 1.4e-18 67.4 1.0 3e-08 33.4 0.2 3.4 3 1 0 3 3 3 3 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO22256.1 - 6.7e-11 42.3 1.7 8.4e-11 41.9 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO22256.1 - 1.6e-05 24.2 0.3 0.015 14.4 0.2 2.4 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 KOO22256.1 - 0.0017 18.0 0.3 0.35 10.4 0.1 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase LRR_6 PF13516.6 KOO22257.1 - 2.7e-07 30.1 1.3 0.084 13.0 0.0 5.4 5 0 0 5 5 5 2 Leucine Rich repeat NACHT PF05729.12 KOO22257.1 - 0.00079 19.4 0.1 0.0016 18.4 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 KOO22257.1 - 0.0051 17.1 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO22257.1 - 0.013 15.9 0.1 0.05 14.0 0.1 2.0 1 0 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.25 KOO22258.1 - 1.9e-39 135.7 0.0 2.8e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22258.1 - 2.8e-13 49.7 0.0 5.2e-13 48.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO22258.1 - 0.0058 15.5 0.1 0.036 12.9 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase EF-hand_1 PF00036.32 KOO22258.1 - 0.0081 15.6 1.4 3.4 7.4 1.7 2.7 2 0 0 2 2 2 2 EF hand Fez1 PF06818.15 KOO22258.1 - 0.011 16.2 7.9 0.017 15.6 7.9 1.2 1 0 0 1 1 1 0 Fez1 EF-hand_7 PF13499.6 KOO22258.1 - 0.29 11.6 3.2 6.8 7.2 1.9 3.1 2 1 1 3 3 3 0 EF-hand domain pair FUSC PF04632.12 KOO22258.1 - 4.5 5.7 7.5 7.3 5.0 7.5 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Arm PF00514.23 KOO22260.1 - 2.3e-05 24.3 7.2 0.16 12.1 0.3 4.6 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO22260.1 - 0.00064 20.2 8.1 0.34 11.5 0.2 4.3 3 0 0 3 3 3 2 HEAT-like repeat Arm_2 PF04826.13 KOO22260.1 - 0.00085 18.9 0.4 0.024 14.1 0.0 2.7 3 1 1 4 4 4 1 Armadillo-like HEAT PF02985.22 KOO22260.1 - 0.076 13.3 7.4 3.9 8.0 0.2 4.4 4 0 0 4 4 4 0 HEAT repeat DUF92 PF01940.16 KOO22261.1 - 1.6e-77 260.1 5.2 1.6e-77 260.1 5.2 1.5 2 0 0 2 2 2 1 Integral membrane protein DUF92 CrgA PF06781.12 KOO22261.1 - 2.9 8.0 5.1 3.7 7.7 1.7 2.5 2 1 0 2 2 2 0 Cell division protein CrgA Prefoldin PF02996.17 KOO22262.1 - 1.2e-23 83.3 0.7 1.8e-23 82.7 0.7 1.3 1 0 0 1 1 1 1 Prefoldin subunit LRR_6 PF13516.6 KOO22263.1 - 7.2e-30 100.5 13.1 5.7e-05 22.9 0.0 7.4 6 1 1 7 7 7 7 Leucine Rich repeat LRR_1 PF00560.33 KOO22263.1 - 0.0036 17.6 0.0 21 6.2 0.0 4.7 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO22263.1 - 0.083 12.7 0.2 12 5.8 0.0 3.8 5 0 0 5 5 5 0 Leucine rich repeat HOASN PF14515.6 KOO22263.1 - 0.11 12.9 7.1 37 4.8 0.1 4.8 1 1 4 5 5 5 0 Haem-oxygenase-associated N-terminal helices LRR_4 PF12799.7 KOO22263.1 - 0.2 12.1 2.1 11 6.6 0.0 3.9 4 2 0 4 4 4 0 Leucine Rich repeats (2 copies) CbiG_N PF11760.8 KOO22263.1 - 0.54 10.3 7.0 12 6.0 0.0 4.6 5 0 0 5 5 5 0 Cobalamin synthesis G N-terminal Arm-DNA-bind_1 PF09003.10 KOO22263.1 - 7.2 6.8 10.3 29 4.9 0.2 4.5 3 2 2 5 5 5 0 Bacteriophage lambda integrase, Arm DNA-binding domain zf-C3HC4_3 PF13920.6 KOO22264.1 - 9.9e-10 38.1 12.7 1.3e-09 37.7 12.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO22264.1 - 1.8e-08 34.1 8.9 2.8e-08 33.5 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO22264.1 - 7.6e-08 32.1 9.0 1.2e-07 31.5 9.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KOO22264.1 - 1.5e-07 31.1 8.5 3.6e-07 29.9 8.7 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO22264.1 - 1.7e-06 28.0 6.0 2.2e-05 24.4 2.9 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 KOO22264.1 - 3.5e-06 27.3 12.4 5.4e-06 26.6 12.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KOO22264.1 - 6.2e-06 26.1 11.5 1e-05 25.4 11.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOO22264.1 - 8.3e-05 22.7 10.1 0.00013 22.0 10.1 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 KOO22264.1 - 0.00067 19.7 2.3 0.00097 19.1 2.3 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 KOO22264.1 - 0.0012 18.7 7.0 0.0023 17.8 7.0 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 KOO22264.1 - 0.0015 18.8 6.1 0.0026 18.0 6.1 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KOO22264.1 - 0.052 13.3 7.2 0.28 11.0 5.7 2.4 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_10 PF16685.5 KOO22264.1 - 0.73 10.0 8.2 1.3 9.2 8.2 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-Nse PF11789.8 KOO22264.1 - 0.91 9.4 6.0 1.5 8.7 6.0 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 KOO22264.1 - 1.8 8.4 10.2 3.3 7.6 10.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1644 PF07800.12 KOO22264.1 - 4.8 7.2 9.7 13 5.9 4.9 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1644) Lycopene_cycl PF05834.12 KOO22265.1 - 8.5e-71 239.0 0.0 1.3e-70 238.4 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 KOO22265.1 - 1.4e-07 31.1 0.0 3.3e-06 26.6 0.0 2.6 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOO22265.1 - 7.9e-06 26.0 0.1 5.3e-05 23.4 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO22265.1 - 6.2e-05 22.7 0.2 0.0094 15.6 0.0 2.4 1 1 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 KOO22265.1 - 0.00025 20.0 0.0 0.039 12.8 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Thi4 PF01946.17 KOO22265.1 - 0.00036 19.9 0.1 0.1 11.8 0.0 2.2 2 0 0 2 2 2 2 Thi4 family FAD_oxidored PF12831.7 KOO22265.1 - 0.00038 19.9 0.6 0.0042 16.5 0.6 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOO22265.1 - 0.00041 19.2 0.0 0.00056 18.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 KOO22265.1 - 0.00093 18.4 0.0 0.0061 15.7 0.0 2.2 3 0 0 3 3 3 1 FAD binding domain GIDA PF01134.22 KOO22265.1 - 0.003 16.7 0.0 0.0044 16.2 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 KOO22265.1 - 0.0031 16.8 0.0 0.0057 15.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.18 KOO22265.1 - 0.016 15.1 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 KOO22265.1 - 0.041 14.5 0.0 0.18 12.4 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 KOO22265.1 - 0.14 12.5 0.0 0.39 11.0 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain PsaD PF02531.16 KOO22266.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 PsaD E1_dh PF00676.20 KOO22268.1 - 6.3e-77 258.5 0.0 7.9e-77 258.1 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 KOO22268.1 - 0.00067 19.5 0.0 0.0027 17.5 0.0 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Mto2_bdg PF12808.7 KOO22268.1 - 0.048 13.9 3.9 0.091 13.1 3.9 1.4 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region tRNA-synt_2b PF00587.25 KOO22269.1 - 2.5e-40 138.4 0.0 4.1e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KOO22269.1 - 4.2e-11 42.8 0.0 1e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 KOO22269.1 - 8.1e-10 38.6 0.0 1.6e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Glyco_hydro_42 PF02449.15 KOO22269.1 - 0.0024 17.3 0.0 0.0041 16.5 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase CCER1 PF15482.6 KOO22269.1 - 0.011 15.6 0.8 0.025 14.5 0.8 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 RNA_lig_T4_1 PF09511.10 KOO22271.1 - 4.2e-12 46.4 0.0 4.7e-11 43.0 0.0 2.1 1 1 0 1 1 1 1 RNA ligase Helicase_C PF00271.31 KOO22272.1 - 5.4e-09 36.4 0.0 1e-08 35.5 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DER1 PF04511.15 KOO22273.1 - 2.5e-24 86.3 6.5 2.9e-24 86.1 6.5 1.0 1 0 0 1 1 1 1 Der1-like family IL4_i_Ig PF18258.1 KOO22273.1 - 0.074 13.3 0.1 0.19 12.0 0.0 1.6 2 0 0 2 2 2 0 Interleukin-4 inducing immunoglobulin-binding domain DUF3119 PF11317.8 KOO22275.1 - 5.5e-35 120.4 0.1 7.5e-35 120.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3119) Mito_carr PF00153.27 KOO22276.1 - 1.9e-58 194.4 1.1 1.6e-18 66.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOO22276.1 - 0.029 13.5 0.1 0.58 9.3 0.0 2.6 3 0 0 3 3 3 0 Gammaproteobacterial serine protease GDP_Man_Dehyd PF16363.5 KOO22277.1 - 1.6e-60 205.3 0.0 1.8e-60 205.1 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOO22277.1 - 5.9e-52 176.5 0.0 7.1e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO22277.1 - 5.6e-14 51.8 0.0 9.8e-14 51.0 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KOO22277.1 - 1.2e-11 44.3 0.0 8.3e-11 41.6 0.0 2.2 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 KOO22277.1 - 3.7e-09 36.1 0.0 5.4e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 KOO22277.1 - 1.2e-05 25.3 0.0 1.7e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 KOO22277.1 - 2.5e-05 23.8 0.1 4.4e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 KOO22277.1 - 4e-05 22.9 0.0 0.0051 16.0 0.0 2.4 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 KOO22277.1 - 0.00019 21.4 0.1 0.00056 19.9 0.1 1.7 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 KOO22277.1 - 0.0019 18.1 0.1 0.0044 16.9 0.1 1.5 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NmrA PF05368.13 KOO22277.1 - 0.0094 15.5 0.1 0.042 13.4 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family NAD_binding_2 PF03446.15 KOO22277.1 - 0.14 12.3 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Ion_trans PF00520.31 KOO22278.1 - 1.8e-47 161.7 20.0 6.8e-24 84.4 4.9 2.3 2 0 0 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 KOO22278.1 - 4.9e-22 77.7 10.1 1.5e-13 50.5 1.2 3.3 4 0 0 4 4 4 2 Ion channel cNMP_binding PF00027.29 KOO22278.1 - 5.3e-16 58.5 0.0 1.5e-15 57.1 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Hrs_helical PF12210.8 KOO22278.1 - 0.21 12.2 2.8 0.16 12.5 0.4 2.0 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate OPA3 PF07047.12 KOO22279.1 - 3.3e-26 91.5 1.0 5.3e-26 90.8 0.7 1.6 1 1 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DUF2514 PF10721.9 KOO22279.1 - 0.006 16.6 6.7 0.0097 16.0 6.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2514) RIC3 PF15361.6 KOO22279.1 - 0.014 15.7 0.0 0.026 14.9 0.0 1.4 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF1664 PF07889.12 KOO22279.1 - 0.075 13.1 0.2 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CCDC23 PF15674.5 KOO22279.1 - 4.3 7.4 6.3 12 6.0 5.9 1.9 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 23 PFK PF00365.20 KOO22280.1 - 1.8e-20 73.4 0.0 1.3e-19 70.7 0.0 2.0 1 1 0 1 1 1 1 Phosphofructokinase DUF4259 PF14078.6 KOO22280.1 - 0.024 15.4 5.7 1.1 10.0 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4259) LRR_6 PF13516.6 KOO22281.1 - 0.31 11.2 6.4 1.2 9.4 0.1 3.8 4 0 0 4 4 4 0 Leucine Rich repeat DUF724 PF05266.14 KOO22281.1 - 1.4 8.7 18.2 0.33 10.8 5.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF724) MFS_1 PF07690.16 KOO22284.1 - 0.00054 19.0 9.4 0.00054 19.0 9.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO22284.1 - 0.068 12.0 4.4 0.26 10.1 0.6 2.3 2 1 0 2 2 2 0 Sugar (and other) transporter LRR_5 PF13306.6 KOO22285.1 - 4.2e-152 498.8 0.0 7.9e-41 139.0 0.0 4.0 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO22285.1 - 7.2e-22 76.9 0.0 0.006 16.3 0.0 9.5 2 1 11 13 13 13 10 Leucine rich repeat Hexapep_2 PF14602.6 KOO22285.1 - 0.035 13.8 0.1 36 4.2 0.0 4.6 5 0 0 5 5 5 0 Hexapeptide repeat of succinyl-transferase DUF2240 PF09999.9 KOO22285.1 - 0.17 11.5 0.0 2.9 7.5 0.0 2.7 2 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2240) Forkhead_N PF08430.12 KOO22285.1 - 0.17 12.5 26.0 5.3e+02 1.2 11.3 4.5 1 1 1 2 2 2 0 Forkhead N-terminal region Peptidase_M8 PF01457.16 KOO22285.1 - 6.8 5.2 5.3 93 1.5 0.1 3.8 1 1 6 7 7 7 0 Leishmanolysin Shadoo PF14999.6 KOO22286.1 - 0.12 12.4 5.4 0.27 11.4 5.4 1.5 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective Pkinase PF00069.25 KOO22287.1 - 1.2e-33 116.6 0.0 1.7e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22287.1 - 4.1e-28 98.4 0.0 6e-28 97.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO22287.1 - 0.0017 17.7 0.0 0.0024 17.2 0.0 1.1 1 0 0 1 1 1 1 Kinase-like GATase_5 PF13507.6 KOO22288.1 - 1.1e-99 332.8 0.0 1.6e-99 332.2 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 KOO22288.1 - 1.2e-14 54.7 0.6 2e-14 54.0 0.6 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain DUF3584 PF12128.8 KOO22289.1 - 0.035 11.6 7.5 0.059 10.9 7.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SCAB_CC PF16712.5 KOO22289.1 - 0.067 13.0 4.7 0.2 11.5 4.7 1.8 1 0 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein Filament PF00038.21 KOO22289.1 - 0.22 11.1 9.8 0.63 9.6 9.8 1.8 1 0 0 1 1 1 0 Intermediate filament protein AAA_13 PF13166.6 KOO22289.1 - 2.1 6.9 4.6 4.1 5.9 4.6 1.3 1 0 0 1 1 1 0 AAA domain DUF572 PF04502.13 KOO22289.1 - 3.5 7.1 8.4 0.21 11.2 2.6 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF572) Fmp27_WPPW PF10359.9 KOO22289.1 - 7.7 5.2 7.0 7.9 5.2 3.7 2.0 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Lectin_legB PF00139.19 KOO22290.1 - 1.1e-10 41.4 0.0 3.9e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 Legume lectin domain Bact_lectin PF18483.1 KOO22290.1 - 3.9e-09 36.8 0.0 1.5e-08 34.9 0.0 1.8 2 0 0 2 2 2 1 Bacterial lectin PLAT PF01477.23 KOO22290.1 - 4.7e-05 23.9 0.1 0.27 11.8 0.0 2.6 2 0 0 2 2 2 2 PLAT/LH2 domain FIVAR PF07554.13 KOO22290.1 - 0.043 14.6 1.2 2.7 8.8 0.1 2.5 2 0 0 2 2 2 0 FIVAR domain HGTP_anticodon2 PF12745.7 KOO22291.1 - 0.37 10.3 2.6 0.48 9.9 2.6 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Caskin-Pro-rich PF16907.5 KOO22291.1 - 0.49 10.9 5.7 0.94 10.0 5.4 1.6 1 1 0 1 1 1 0 Proline rich region of Caskin proteins PDGF_N PF04692.13 KOO22291.1 - 5.3 7.9 7.3 7.8 7.4 5.8 2.1 1 1 2 3 3 3 0 Platelet-derived growth factor, N terminal region EF-hand_1 PF00036.32 KOO22294.1 - 1.5e-11 43.0 0.3 4e-05 22.9 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO22294.1 - 4.1e-11 41.9 0.0 0.00011 21.8 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KOO22294.1 - 4.4e-11 41.8 1.4 2.5e-05 23.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO22294.1 - 1.9e-09 37.8 0.0 6.4e-08 32.9 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO22294.1 - 6.6e-08 32.3 0.3 0.006 16.4 0.4 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO22294.1 - 0.00037 20.4 0.0 0.0013 18.7 0.0 2.0 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO22294.1 - 0.17 11.7 1.2 1.9 8.4 0.1 2.7 3 0 0 3 3 3 0 EF hand DUF5577 PF17740.1 KOO22295.1 - 0.074 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5577) DUF4326 PF14216.6 KOO22296.1 - 0.00028 21.5 0.3 0.00084 20.0 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4326) RVT_1 PF00078.27 KOO22296.1 - 0.0057 16.2 0.0 0.0099 15.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YkyA PF10368.9 KOO22297.1 - 0.012 15.3 1.0 0.033 13.9 0.4 2.1 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Prominin PF05478.11 KOO22297.1 - 1 7.2 7.1 1 7.2 0.5 2.7 2 1 0 3 3 3 0 Prominin GLF PF03275.13 KOO22298.1 - 2.6e-72 242.9 0.3 3.5e-72 242.4 0.3 1.2 1 0 0 1 1 1 1 UDP-galactopyranose mutase NAD_binding_8 PF13450.6 KOO22298.1 - 2.8e-16 59.5 0.1 4.9e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 KOO22298.1 - 0.004 16.5 0.0 0.06 12.7 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KOO22298.1 - 0.1 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 KOO22298.1 - 0.33 10.2 0.4 0.68 9.1 0.2 1.6 2 0 0 2 2 2 0 FAD binding domain Rad51 PF08423.11 KOO22299.1 - 8.6e-24 84.2 0.0 1.6e-15 57.0 0.0 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 KOO22299.1 - 2e-08 34.0 0.9 4.9e-08 32.8 0.9 1.6 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 KOO22299.1 - 1.1e-07 31.5 0.0 1.6e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 KaiC RecA PF00154.21 KOO22299.1 - 2.7e-06 27.0 0.1 6.2e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_22 PF13401.6 KOO22299.1 - 0.00039 20.7 0.0 0.002 18.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO22299.1 - 0.0021 17.8 0.1 0.0056 16.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO22299.1 - 0.0089 16.4 0.0 0.018 15.5 0.1 1.5 2 0 0 2 2 1 1 AAA ATPase domain PhoH PF02562.16 KOO22299.1 - 0.0096 15.4 0.1 0.02 14.4 0.1 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_24 PF13479.6 KOO22299.1 - 0.012 15.4 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 KOO22299.1 - 0.026 14.3 0.1 0.04 13.7 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein MFS_1 PF07690.16 KOO22299.1 - 0.06 12.3 20.1 0.086 11.8 20.1 1.3 1 0 0 1 1 1 0 Major Facilitator Superfamily AAA PF00004.29 KOO22299.1 - 0.067 13.6 0.1 0.12 12.8 0.1 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 KOO22299.1 - 0.16 12.3 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO22299.1 - 0.22 11.7 0.2 0.49 10.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KOO22299.1 - 0.23 10.6 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Pkinase PF00069.25 KOO22300.1 - 1.5e-76 257.3 0.0 1.9e-76 256.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22300.1 - 6.1e-35 120.7 0.1 5.9e-34 117.5 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO22300.1 - 6.2e-05 22.4 0.0 0.00055 19.4 0.0 2.2 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 KOO22300.1 - 0.0032 17.1 0.1 0.0054 16.3 0.1 1.2 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 KOO22300.1 - 0.0052 16.4 0.1 1.5 8.4 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 KOO22300.1 - 0.055 12.4 0.1 0.079 11.9 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KOO22300.1 - 0.12 12.2 0.1 0.41 10.5 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family tRNA-synt_2c PF01411.19 KOO22301.1 - 1.6e-203 677.2 0.0 2e-203 676.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 KOO22301.1 - 2.1e-15 56.5 0.0 4.7e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 KOO22301.1 - 4e-12 46.7 3.2 1.1e-11 45.3 3.2 1.7 1 0 0 1 1 1 1 DHHA1 domain Vps35 PF03635.17 KOO22302.1 - 4.8e-69 233.7 2.4 2e-48 165.5 1.8 3.0 1 1 2 3 3 3 3 Vacuolar protein sorting-associated protein 35 NMT_C PF02799.15 KOO22303.1 - 2.3e-54 184.1 0.3 3.3e-54 183.6 0.3 1.1 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 KOO22303.1 - 3.6e-39 134.2 0.5 1.1e-25 90.3 0.1 2.7 2 1 1 3 3 3 2 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain MCM PF00493.23 KOO22304.1 - 1.2e-94 315.7 0.0 1.6e-94 315.2 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 KOO22304.1 - 4.7e-24 84.6 3.5 7.9e-24 83.9 3.5 1.4 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 KOO22304.1 - 8.6e-18 64.4 0.0 1.5e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 KOO22304.1 - 2.3e-08 33.7 0.1 1.2e-06 28.0 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KOO22304.1 - 0.0094 15.8 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO22304.1 - 0.014 15.4 0.0 0.037 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 KOO22304.1 - 0.016 14.9 0.0 0.06 13.1 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Golgin_A5 PF09787.9 KOO22307.1 - 0.44 10.0 30.2 0.15 11.5 26.1 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Baculo_PEP_C PF04513.12 KOO22307.1 - 1.9 8.6 12.2 9 6.3 0.9 3.0 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus FliD_C PF07195.12 KOO22307.1 - 6.5 6.1 16.1 3.7 6.9 2.5 3.0 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus DUF2456 PF10445.9 KOO22308.1 - 0.083 13.0 0.4 0.13 12.3 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2456) IQ PF00612.27 KOO22309.1 - 0.028 14.2 0.6 0.069 13.0 0.6 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ion_trans PF00520.31 KOO22309.1 - 0.047 12.9 17.5 0.067 12.4 12.7 2.7 2 1 0 2 2 2 0 Ion transport protein DUF2650 PF10853.8 KOO22309.1 - 0.33 10.7 1.9 0.44 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2650) HhH-GPD PF00730.25 KOO22310.1 - 7.6e-18 65.0 0.1 1.8e-17 63.7 0.0 1.7 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KOO22310.1 - 5.3e-05 22.9 0.1 0.00015 21.4 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif ADH_zinc_N PF00107.26 KOO22311.1 - 5.6e-16 58.7 0.7 1.1e-14 54.5 0.7 2.3 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOO22311.1 - 9.5e-16 57.6 1.6 3e-15 56.0 1.1 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KOO22311.1 - 0.0001 23.3 0.0 0.00063 20.8 0.0 2.4 2 1 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 KOO22311.1 - 0.00054 19.3 0.2 0.00054 19.3 0.2 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 KOO22311.1 - 0.0006 19.2 0.3 0.001 18.5 0.3 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 KOO22311.1 - 0.057 13.7 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain CoA_binding PF02629.19 KOO22311.1 - 0.063 14.0 1.0 4.8 7.9 0.3 2.5 1 1 1 2 2 2 0 CoA binding domain Arm PF00514.23 KOO22312.1 - 1.8e-52 173.9 5.0 7e-13 48.1 0.0 5.6 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO22312.1 - 2e-18 66.5 2.6 3.2e-11 43.5 0.0 3.6 4 1 1 5 5 4 2 HEAT-like repeat IBB PF01749.20 KOO22312.1 - 4.8e-17 62.2 0.4 1.8e-16 60.3 0.3 2.0 2 0 0 2 2 2 1 Importin beta binding domain HEAT PF02985.22 KOO22312.1 - 2.1e-10 39.9 2.5 9.9e-06 25.4 0.0 4.5 4 1 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 KOO22312.1 - 2.2e-10 40.8 0.1 1e-06 29.0 0.0 3.9 1 1 3 4 4 4 3 HEAT repeats HEAT_PBS PF03130.16 KOO22312.1 - 0.00023 21.5 0.1 0.17 12.6 0.0 3.8 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat V-ATPase_H_C PF11698.8 KOO22312.1 - 0.0028 17.7 0.0 0.22 11.6 0.0 2.3 2 0 0 2 2 2 1 V-ATPase subunit H Atx10homo_assoc PF09759.9 KOO22312.1 - 0.0034 17.4 0.0 0.076 13.0 0.0 2.4 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain RICTOR_V PF14668.6 KOO22312.1 - 0.018 15.2 0.2 0.81 10.0 0.1 3.0 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 KOO22312.1 - 0.1 12.1 0.0 0.35 10.3 0.0 1.7 1 1 1 2 2 2 0 Armadillo-like Adaptin_N PF01602.20 KOO22312.1 - 0.27 9.8 0.0 0.34 9.4 0.0 1.2 1 0 0 1 1 1 0 Adaptin N terminal region Nuc_sug_transp PF04142.15 KOO22313.1 - 1.9e-57 194.8 3.8 2.2e-57 194.6 3.8 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.16 KOO22313.1 - 9.9e-05 21.8 0.4 9.9e-05 21.8 0.4 2.6 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.20 KOO22313.1 - 0.00063 19.9 21.5 0.0011 19.1 3.6 2.5 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO22313.1 - 0.023 13.9 7.8 0.55 9.4 7.8 2.1 1 1 0 1 1 1 0 UAA transporter family Pkinase PF00069.25 KOO22314.1 - 1e-49 169.3 0.0 1.3e-49 169.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22314.1 - 4.2e-28 98.3 0.0 4.9e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO22314.1 - 1.5e-06 28.3 0.0 2.5e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO22314.1 - 0.00019 20.8 0.0 0.00039 19.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO22314.1 - 0.00081 18.8 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO22314.1 - 0.013 14.3 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 KOO22314.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family LSM PF01423.22 KOO22315.1 - 2.4e-18 65.6 0.4 3.1e-18 65.2 0.4 1.1 1 0 0 1 1 1 1 LSM domain Tail_tube PF10618.9 KOO22315.1 - 0.0059 16.5 0.1 0.009 15.9 0.1 1.2 1 0 0 1 1 1 1 Phage tail tube protein SM-ATX PF14438.6 KOO22315.1 - 0.011 15.8 0.3 0.015 15.4 0.3 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain BPL_C PF02237.17 KOO22315.1 - 0.018 14.9 0.5 0.03 14.2 0.2 1.5 2 0 0 2 2 2 0 Biotin protein ligase C terminal domain Gemin7 PF11095.8 KOO22315.1 - 0.16 11.8 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) Glyco_hydro_30 PF02055.16 KOO22316.1 - 4.6e-76 256.0 0.2 7.4e-76 255.4 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Ricin_B_lectin PF00652.22 KOO22316.1 - 1.7e-07 31.6 0.0 3.4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_hydro_30C PF17189.4 KOO22316.1 - 9.7e-06 25.7 0.2 2.5e-05 24.4 0.2 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 KOO22316.1 - 1.1e-05 24.9 0.1 1.7e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 RicinB_lectin_2 PF14200.6 KOO22316.1 - 7.3e-05 23.4 0.1 0.049 14.4 0.1 3.0 2 1 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Herpes_capsid PF06112.11 KOO22316.1 - 0.91 9.6 4.8 1.8 8.6 4.8 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Ribosomal_60s PF00428.19 KOO22316.1 - 5.1 7.8 15.8 13 6.5 15.8 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein UvrD-helicase PF00580.21 KOO22317.1 - 1.4e-53 182.5 0.0 3.7e-53 181.1 0.0 1.7 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 KOO22317.1 - 3.6e-27 95.7 0.0 3.3e-18 66.2 0.0 2.2 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 KOO22317.1 - 1.6e-21 77.2 0.2 4.5e-21 75.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 KOO22317.1 - 2.3e-10 40.1 0.1 1.1e-09 37.9 0.1 2.2 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 KOO22317.1 - 0.00076 19.3 0.1 0.0037 17.0 0.1 2.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOO22317.1 - 0.016 15.5 0.1 4.3 7.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 KOO22317.1 - 0.17 11.7 0.0 0.49 10.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain DDT PF02791.17 KOO22318.1 - 9.8e-09 35.4 0.5 1.7e-08 34.6 0.5 1.4 1 0 0 1 1 1 1 DDT domain HMG_box PF00505.19 KOO22318.1 - 7.1e-06 26.3 3.2 1.5e-05 25.3 1.6 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO22318.1 - 0.0002 21.9 3.4 0.0005 20.6 1.1 2.4 2 0 0 2 2 2 1 HMG-box domain EF-hand_1 PF00036.32 KOO22319.1 - 7.4e-26 87.7 2.3 1.7e-08 33.4 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO22319.1 - 5.4e-22 78.0 1.8 5.9e-12 45.9 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO22319.1 - 8.8e-19 65.8 1.8 1.2e-06 27.9 0.0 5.1 4 2 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KOO22319.1 - 8.1e-16 56.7 0.2 0.00016 21.0 0.0 5.1 4 1 1 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO22319.1 - 8.4e-15 54.4 8.1 1.9e-05 24.4 0.3 4.2 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 KOO22319.1 - 1.8e-07 31.4 0.0 0.026 14.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO22319.1 - 1.3e-05 25.1 1.6 0.19 11.7 0.3 3.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 KOO22319.1 - 0.0067 16.4 0.0 1.5 8.7 0.0 2.8 1 1 2 3 3 3 1 Caleosin related protein EF-hand_11 PF08976.11 KOO22319.1 - 0.0083 17.0 0.0 0.014 16.2 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain Dockerin_1 PF00404.18 KOO22319.1 - 0.061 13.5 0.2 0.49 10.6 0.2 2.2 1 1 1 2 2 2 0 Dockerin type I domain DUF3008 PF11450.8 KOO22319.1 - 0.081 13.1 0.9 0.3 11.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknwon function (DUF3008) EF-hand_14 PF17959.1 KOO22319.1 - 0.088 13.2 0.2 16 6.0 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain Glyco_hyd_65N_2 PF14498.6 KOO22319.1 - 0.088 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain FKBP_C PF00254.28 KOO22320.1 - 2.9e-19 69.2 0.0 5.1e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase SAPS PF04499.15 KOO22320.1 - 0.14 11.0 2.7 0.16 10.7 2.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PdaC PF13739.6 KOO22320.1 - 0.28 12.2 2.3 1.9 9.5 1.7 2.1 2 0 0 2 2 2 0 Deacetylase PdaC PCRF PF03462.18 KOO22320.1 - 1.2 9.0 7.7 1.7 8.5 7.7 1.2 1 0 0 1 1 1 0 PCRF domain Caldesmon PF02029.15 KOO22320.1 - 4.3 6.0 16.9 5.6 5.6 16.9 1.1 1 0 0 1 1 1 0 Caldesmon Atg14 PF10186.9 KOO22320.1 - 9.5 5.2 8.0 13 4.8 8.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TIG PF01833.24 KOO22321.1 - 1.8e-144 470.2 79.4 3.7e-10 39.7 1.5 30.7 30 2 0 30 30 30 24 IPT/TIG domain TIG_plexin PF17960.1 KOO22321.1 - 7.6e-34 115.6 0.0 0.31 11.1 0.0 20.1 24 0 0 24 24 24 10 TIG domain hemP PF10636.9 KOO22321.1 - 0.18 11.6 0.1 39 4.2 0.0 4.1 3 0 0 3 3 3 0 Hemin uptake protein hemP Bact_lectin PF18483.1 KOO22321.1 - 2.5 8.1 6.8 29 4.6 0.2 3.9 4 0 0 4 4 4 0 Bacterial lectin Pkinase_Tyr PF07714.17 KOO22322.1 - 3.5e-37 128.1 0.0 1.7e-36 125.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO22322.1 - 6.7e-37 127.3 0.0 1.5e-36 126.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain DUF4448 PF14610.6 KOO22322.1 - 0.00015 21.6 0.1 0.00033 20.5 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF4381 PF14316.6 KOO22322.1 - 0.064 13.5 2.8 3.4 7.9 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Herpes_gE PF02480.16 KOO22322.1 - 0.079 11.7 0.3 0.13 10.9 0.3 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E CRC_subunit PF08624.10 KOO22322.1 - 0.083 13.3 0.0 0.66 10.4 0.0 2.2 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit FTA2 PF13095.6 KOO22322.1 - 0.17 11.5 0.0 13 5.3 0.0 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 TMEM100 PF16311.5 KOO22322.1 - 8.9 5.9 7.4 0.49 10.0 1.4 2.0 2 0 0 2 2 2 0 Transmembrane protein 100 Methyltransf_5 PF01795.19 KOO22323.1 - 1.1e-86 291.1 0.0 1.1e-46 159.7 0.1 2.0 2 0 0 2 2 2 2 MraW methylase family Methyltransf_31 PF13847.6 KOO22323.1 - 0.00058 19.7 0.0 0.21 11.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 KOO22323.1 - 0.0021 18.7 0.1 4.8 7.9 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22323.1 - 0.026 15.2 0.1 0.8 10.4 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOO22323.1 - 0.13 13.0 0.1 8.5 7.2 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain WD40 PF00400.32 KOO22324.1 - 6.4e-23 80.6 0.2 1.2e-07 32.3 0.2 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO22324.1 - 1.7e-11 44.2 0.0 0.0053 17.0 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO22324.1 - 0.00018 20.6 0.5 0.89 8.5 0.0 2.8 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 KOO22324.1 - 0.00033 21.0 1.0 0.0056 17.1 0.0 2.9 3 0 0 3 3 3 1 PQQ-like domain CPSF_A PF03178.15 KOO22324.1 - 0.015 14.7 0.0 0.8 9.0 0.0 2.1 2 0 0 2 2 2 0 CPSF A subunit region Frtz PF11768.8 KOO22324.1 - 0.031 12.6 0.0 0.033 12.5 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz NHL PF01436.21 KOO22324.1 - 0.035 14.1 0.2 66 3.8 0.0 3.7 3 0 0 3 3 3 0 NHL repeat TruB_C PF09142.11 KOO22324.1 - 0.048 13.4 0.5 9.7 6.1 0.1 2.5 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal Cytochrom_D1 PF02239.16 KOO22324.1 - 0.062 11.8 0.2 0.42 9.1 0.1 1.8 1 1 2 3 3 3 0 Cytochrome D1 heme domain Nup160 PF11715.8 KOO22324.1 - 0.11 11.2 0.0 0.11 11.2 0.0 1.3 1 1 0 1 1 1 0 Nucleoporin Nup120/160 CNH PF00780.22 KOO22324.1 - 0.17 11.5 0.0 0.43 10.1 0.0 1.6 2 0 0 2 2 2 0 CNH domain Methyltransf_22 PF13383.6 KOO22326.1 - 0.0019 17.8 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Pkinase PF00069.25 KOO22328.1 - 7.6e-44 150.0 0.0 1.4e-43 149.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22328.1 - 2.3e-15 56.6 0.0 5.1e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO22328.1 - 1.9e-08 34.0 0.0 0.00019 20.8 0.0 2.6 1 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KOO22328.1 - 0.00019 20.4 0.0 0.00019 20.4 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 KOO22328.1 - 0.0049 16.4 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 KOO22328.1 - 0.013 15.1 0.0 0.031 13.9 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase XhlA PF10779.9 KOO22328.1 - 0.39 11.0 11.5 3.3 8.0 0.2 5.4 4 1 1 5 5 5 0 Haemolysin XhlA LST1 PF05083.13 KOO22328.1 - 1.4 9.2 7.7 36 4.7 0.1 4.6 2 2 2 4 4 4 0 LST-1 protein VCBS PF13517.6 KOO22330.1 - 4e-64 213.1 59.8 4.1e-14 52.9 4.3 6.4 2 2 4 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO22330.1 - 3.8e-36 122.8 70.9 2.7e-05 24.2 3.6 7.4 7 0 0 7 7 7 7 FG-GAP repeat Dockerin_1 PF00404.18 KOO22330.1 - 1.7e-06 28.1 22.9 5.3 7.3 0.0 7.2 6 1 1 7 7 7 3 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO22330.1 - 2.8e-06 26.8 25.5 2.7 7.3 0.1 7.1 4 2 3 7 7 7 6 Insecticide toxin TcdB middle/N-terminal region HET-s_218-289 PF11558.8 KOO22330.1 - 1.2e-05 25.2 0.0 25 5.0 0.0 6.2 7 0 0 7 7 7 0 Het-s 218-289 BBS1 PF14779.6 KOO22330.1 - 0.00063 19.3 0.3 68 2.8 0.0 6.0 7 0 0 7 7 7 0 Ciliary BBSome complex subunit 1 TM_PBP2_N PF16296.5 KOO22330.1 - 0.00082 19.4 0.1 24 5.1 0.0 5.3 7 0 0 7 7 7 0 N-terminal of TM subunit in PBP-dependent ABC transporters EF-hand_1 PF00036.32 KOO22330.1 - 0.0075 15.7 30.0 19 5.1 0.2 7.1 7 0 0 7 7 7 2 EF hand EF-hand_5 PF13202.6 KOO22330.1 - 0.063 12.8 45.2 8 6.2 0.7 7.2 7 0 0 7 7 7 0 EF hand FTCD_C PF04961.12 KOO22332.1 - 0.079 12.7 0.4 0.079 12.7 0.4 1.9 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase baeRF_family10 PF18854.1 KOO22332.1 - 0.22 11.8 0.2 0.22 11.8 0.2 1.9 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 DUF1840 PF08895.11 KOO22332.1 - 0.68 10.3 4.9 0.22 11.9 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) GDA1_CD39 PF01150.17 KOO22333.1 - 8.5e-56 189.4 0.0 9e-45 153.1 0.0 2.8 1 1 1 2 2 2 2 GDA1/CD39 (nucleoside phosphatase) family PMSR PF01625.21 KOO22334.1 - 2.7e-56 190.0 0.1 3.7e-56 189.5 0.1 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Metallophos PF00149.28 KOO22335.1 - 1e-12 49.0 0.0 1.9e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 KOO22335.1 - 2.7e-10 40.7 0.3 2.7e-10 40.7 0.3 2.6 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 KOO22335.1 - 5.6e-09 36.7 0.0 1.8e-08 35.1 0.0 2.0 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C TPR_10 PF13374.6 KOO22336.1 - 1.6e-28 97.7 4.9 7.2e-09 35.2 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO22336.1 - 1.3e-25 89.5 10.9 2.8e-14 53.2 1.5 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO22336.1 - 1.5e-09 37.3 0.5 0.026 14.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO22336.1 - 3e-08 33.1 2.4 0.043 13.6 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO22336.1 - 3.3e-07 29.9 4.8 0.27 11.5 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_4 PF07721.14 KOO22336.1 - 9e-07 28.9 7.4 1.6 9.6 0.0 5.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO22336.1 - 1.7e-06 27.7 3.6 3.9e-06 26.5 3.6 1.6 1 0 0 1 1 1 1 MalT-like TPR region TPR_7 PF13176.6 KOO22336.1 - 1.6e-05 24.6 8.9 0.0012 18.8 0.2 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO22336.1 - 0.00084 19.8 5.1 0.019 15.5 1.2 3.0 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO22336.1 - 0.0024 18.5 1.1 0.0024 18.5 1.1 4.3 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22336.1 - 0.0026 18.4 15.9 0.48 11.4 0.5 4.9 5 0 0 5 5 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO22336.1 - 0.0028 17.9 2.8 8.4 7.0 0.0 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO22336.1 - 0.0032 17.7 0.7 12 6.3 0.0 3.8 4 0 0 4 4 4 1 Osmosensory transporter coiled coil TPR_3 PF07720.12 KOO22336.1 - 0.026 14.5 0.0 5.1 7.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat EF-hand_5 PF13202.6 KOO22337.1 - 4.9e-13 47.9 0.2 8.6e-06 25.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO22337.1 - 5.6e-11 41.4 0.1 2.7e-05 23.8 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO22337.1 - 2e-10 39.4 0.2 0.00021 20.6 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO22337.1 - 7.1e-10 39.2 0.1 6e-09 36.2 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO22337.1 - 3.3e-08 33.2 0.3 0.0052 16.6 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair RIIa PF02197.17 KOO22337.1 - 7.8e-06 25.5 0.2 1.6e-05 24.4 0.2 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit MHB PF16525.5 KOO22337.1 - 0.034 14.4 0.0 0.093 13.0 0.0 1.8 2 0 0 2 2 2 0 Haemophore, haem-binding zf-C3HC4_3 PF13920.6 KOO22338.1 - 4.2e-07 29.7 5.9 7.5e-07 28.9 5.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO22338.1 - 0.1 12.5 7.2 0.19 11.6 7.2 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 CENP-T_C PF15511.6 KOO22339.1 - 1.2e-08 35.1 0.1 1.4e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KOO22339.1 - 0.00011 22.5 0.1 0.00014 22.1 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 KOO22339.1 - 0.00016 21.7 0.2 0.00023 21.3 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 KOO22339.1 - 0.00069 19.9 0.1 0.0011 19.1 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOO22339.1 - 0.00077 19.8 0.3 0.00086 19.7 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 KOO22339.1 - 0.0088 16.1 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KOO22339.1 - 0.0098 15.9 0.1 0.015 15.3 0.1 1.2 1 0 0 1 1 1 1 Bromodomain associated UPF0137 PF03677.13 KOO22339.1 - 0.16 11.7 0.1 0.2 11.4 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Ank_5 PF13857.6 KOO22340.1 - 0.0017 18.6 0.1 0.18 12.2 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO22340.1 - 0.065 13.8 0.0 0.24 12.0 0.0 1.9 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO22340.1 - 0.099 13.3 0.0 7.9 7.4 0.0 3.1 2 0 0 2 2 2 0 Ankyrin repeat Ank PF00023.30 KOO22340.1 - 0.12 12.8 0.0 18 6.0 0.0 3.1 2 0 0 2 2 2 0 Ankyrin repeat DTC PF18102.1 KOO22342.1 - 8.4e-43 145.7 0.0 1e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 Deltex C-terminal domain zf-RING_2 PF13639.6 KOO22342.1 - 0.014 15.7 0.6 0.028 14.7 0.6 1.5 1 0 0 1 1 1 0 Ring finger domain Mito_carr PF00153.27 KOO22343.1 - 1.9e-34 117.5 1.8 3.6e-21 74.9 0.1 2.4 3 0 0 3 3 3 2 Mitochondrial carrier protein TPR_11 PF13414.6 KOO22344.1 - 0.00052 19.6 0.1 0.019 14.7 0.0 3.2 4 0 0 4 4 4 1 TPR repeat TPR_19 PF14559.6 KOO22344.1 - 0.00064 20.2 8.8 0.02 15.4 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO22344.1 - 0.011 15.7 0.0 0.011 15.7 0.0 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO22344.1 - 0.012 15.6 0.0 0.42 10.8 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO22344.1 - 0.013 15.3 0.1 0.28 11.1 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22344.1 - 0.058 14.2 0.1 0.058 14.2 0.1 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO22344.1 - 1.4 8.9 3.8 0.73 9.8 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat BPD_transp_1 PF00528.22 KOO22346.1 - 0.27 10.9 1.5 12 5.6 0.0 3.5 4 0 0 4 4 4 0 Binding-protein-dependent transport system inner membrane component DUF3599 PF12206.8 KOO22346.1 - 0.31 11.4 5.5 21 5.5 0.1 3.6 1 1 3 4 4 4 0 Domain of unknown function (DUF3599) HlyD_3 PF13437.6 KOO22346.1 - 1.1 10.0 7.6 5.6 7.7 0.7 3.2 1 1 2 3 3 3 0 HlyD family secretion protein RPE65 PF03055.15 KOO22347.1 - 2.8e-75 254.3 0.0 5.9e-75 253.2 0.0 1.5 1 1 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF4873 PF16170.5 KOO22347.1 - 0.019 15.2 0.0 0.045 14.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4873) TetR PF13972.6 KOO22348.1 - 0.0066 16.2 1.3 0.035 13.8 0.2 2.1 2 0 0 2 2 2 1 Bacterial transcriptional repressor SNF2_N PF00176.23 KOO22349.1 - 3.7e-57 193.6 0.0 6.2e-57 192.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3578 PF12102.8 KOO22349.1 - 6.4e-33 113.9 0.0 1.7e-32 112.5 0.0 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF3578) Helicase_C PF00271.31 KOO22349.1 - 4.6e-17 62.4 0.0 9e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 KOO22349.1 - 6.2e-12 45.2 0.0 2.3e-07 30.6 0.0 3.4 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 KOO22349.1 - 2.6e-09 36.8 4.9 5.7e-09 35.7 4.9 1.6 1 0 0 1 1 1 1 PHD-finger ResIII PF04851.15 KOO22349.1 - 8.9e-08 32.3 0.0 5.6e-07 29.7 0.0 2.4 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KOO22349.1 - 7.2e-05 22.1 0.1 0.00022 20.5 0.0 1.8 2 0 0 2 2 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 KOO22349.1 - 0.00016 21.5 0.0 0.0019 18.0 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 KOO22349.1 - 0.00065 19.4 0.0 0.0019 17.9 0.0 1.7 2 0 0 2 2 2 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 KOO22349.1 - 0.16 12.2 0.0 1.3 9.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain zf-RING_2 PF13639.6 KOO22349.1 - 2.3 8.6 5.4 6.7 7.1 5.4 1.9 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 KOO22349.1 - 2.9 8.2 4.4 8 6.8 4.4 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain His_Phos_1 PF00300.22 KOO22350.1 - 4.7e-10 39.5 11.9 7.4e-06 25.8 0.5 3.7 3 1 0 3 3 3 2 Histidine phosphatase superfamily (branch 1) GRDA PF04723.14 KOO22350.1 - 0.044 13.6 0.0 0.08 12.7 0.0 1.4 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A DUF2418 PF10332.9 KOO22350.1 - 0.063 13.8 0.1 0.12 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) DUF4336 PF14234.6 KOO22351.1 - 0.00053 19.3 0.0 0.0022 17.2 0.0 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4336) PP2C PF00481.21 KOO22352.1 - 2.2e-33 116.0 0.0 4e-33 115.1 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C Methyltransf_16 PF10294.9 KOO22353.1 - 7.4e-17 61.6 0.0 1.4e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Neur_chan_memb PF02932.16 KOO22353.1 - 5.8e-06 26.5 1.7 5.8e-06 26.5 1.7 2.4 2 1 1 3 3 3 1 Neurotransmitter-gated ion-channel transmembrane region TehB PF03848.14 KOO22353.1 - 0.036 13.5 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_23 PF13489.6 KOO22353.1 - 0.14 12.0 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Cornichon PF03311.14 KOO22354.1 - 0.31 11.4 3.7 0.65 10.3 0.3 2.4 2 0 0 2 2 2 0 Cornichon protein ATP-synt_C PF00137.21 KOO22355.1 - 8.6e-29 99.7 25.3 8.8e-18 64.4 8.9 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Ion_trans PF00520.31 KOO22356.1 - 0.00048 19.4 9.9 0.002 17.4 9.9 1.9 1 1 0 1 1 1 1 Ion transport protein AP1AR PF15745.5 KOO22356.1 - 0.89 9.1 6.4 1.7 8.2 6.4 1.4 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein MFS_1 PF07690.16 KOO22357.1 - 5.2e-15 55.2 32.7 5.2e-15 55.2 32.7 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily LSDAT_euk PF18139.1 KOO22358.1 - 4.8e-48 163.9 0.0 6.1e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 KOO22358.1 - 2.8e-27 95.3 1.0 4.2e-27 94.7 1.0 1.2 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote IQ PF00612.27 KOO22358.1 - 0.038 13.8 0.8 0.095 12.5 0.8 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Lactonase PF10282.9 KOO22359.1 - 1.3e-38 133.2 0.0 1.4e-33 116.6 0.0 3.0 3 0 0 3 3 3 2 Lactonase, 7-bladed beta-propeller Peptidase_S10 PF00450.22 KOO22361.1 - 1.8e-114 383.4 0.0 2.1e-114 383.2 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.7 KOO22361.1 - 5.3e-06 27.2 2.1 0.0017 19.0 2.1 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family WD40 PF00400.32 KOO22363.1 - 1.1e-10 41.9 2.5 3.7e-06 27.6 0.2 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat PQQ_3 PF13570.6 KOO22363.1 - 6.7 7.3 8.9 1.2 9.7 0.2 3.7 3 1 0 3 3 3 0 PQQ-like domain NUDIX PF00293.28 KOO22364.1 - 4.1e-06 26.9 0.3 0.11 12.5 0.0 2.4 2 0 0 2 2 2 2 NUDIX domain Tli4_C PF18426.1 KOO22364.1 - 0.00019 21.8 0.1 0.89 9.8 0.0 2.3 2 0 0 2 2 2 2 Tle cognate immunity protein 4 C-terminal domain GUN4_N PF16416.5 KOO22364.1 - 0.05 13.6 0.1 5.9 6.9 0.0 2.6 2 0 0 2 2 2 0 ARM-like repeat domain, GUN4-N terminal COP23 PF14218.6 KOO22364.1 - 0.058 13.2 0.1 14 5.4 0.0 2.3 2 0 0 2 2 2 0 Circadian oscillating protein COP23 Usg PF06233.12 KOO22364.1 - 0.098 12.8 0.0 27 5.0 0.0 2.5 2 0 0 2 2 2 0 Usg-like family AIG1 PF04548.16 KOO22365.1 - 2.4e-20 72.8 0.0 3.2e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 KOO22365.1 - 6.1e-05 23.1 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GBP PF02263.19 KOO22365.1 - 0.06 12.6 0.0 0.083 12.1 0.0 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain 2OG-FeII_Oxy_3 PF13640.6 KOO22366.1 - 1.5e-15 57.8 0.0 3e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO22366.1 - 0.00016 22.2 2.6 0.00051 20.5 2.6 1.9 1 0 0 1 1 1 1 ShK domain-like BRCC36_C PF18110.1 KOO22366.1 - 0.061 13.5 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain Pkinase PF00069.25 KOO22367.1 - 4.1e-60 203.4 0.0 7e-60 202.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO22367.1 - 9.5e-32 108.9 0.2 7.2e-19 67.7 0.1 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO22367.1 - 3.6e-25 88.7 0.0 5.3e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO22367.1 - 0.0016 17.8 0.0 0.0031 16.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Mto2_bdg PF12808.7 KOO22367.1 - 0.19 12.1 2.8 0.5 10.7 2.8 1.7 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Seadorna_VP7 PF07387.11 KOO22367.1 - 0.2 10.7 0.0 0.31 10.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF2587 PF10759.9 KOO22367.1 - 0.2 11.1 5.1 0.54 9.8 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2587) Haspin_kinase PF12330.8 KOO22367.1 - 0.22 10.5 0.1 0.32 9.9 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain PPR_2 PF13041.6 KOO22369.1 - 5.6e-07 29.7 0.0 0.0011 19.1 0.0 3.1 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 KOO22369.1 - 0.0021 18.1 0.0 0.79 9.8 0.0 2.4 2 0 0 2 2 2 2 Pentatricopeptide repeat domain RPE65 PF03055.15 KOO22370.1 - 3.4e-72 244.1 0.0 3.8e-72 244.0 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Methyltransf_25 PF13649.6 KOO22373.1 - 0.0016 19.1 0.0 0.0026 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 KOO22373.1 - 0.033 13.7 0.1 0.049 13.1 0.1 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltransf_2 PF00891.18 KOO22373.1 - 0.05 12.9 0.0 0.062 12.6 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase domain PABP PF00658.18 KOO22375.1 - 0.0031 17.7 2.9 0.51 10.6 0.2 3.2 3 0 0 3 3 3 2 Poly-adenylate binding protein, unique domain XPC-binding PF09280.11 KOO22375.1 - 0.0075 16.0 9.9 0.7 9.7 0.1 4.2 3 2 0 3 3 3 2 XPC-binding domain QWRF PF04484.12 KOO22375.1 - 0.087 12.6 1.1 0.19 11.5 0.0 1.8 1 1 1 2 2 2 0 QWRF family STI1 PF17830.1 KOO22375.1 - 0.23 11.4 0.2 0.23 11.4 0.2 5.1 3 2 2 5 5 5 0 STI1 domain DUF2999 PF11212.8 KOO22375.1 - 1.2 9.5 11.5 0.058 13.7 4.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2999) Aminotran_4 PF01063.19 KOO22376.1 - 7.1e-25 88.2 0.0 8.7e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV SURF1 PF02104.15 KOO22377.1 - 6.4e-33 114.5 0.0 8.1e-33 114.1 0.0 1.1 1 0 0 1 1 1 1 SURF1 family LRR_6 PF13516.6 KOO22378.1 - 5e-11 41.7 14.8 0.00016 21.5 0.1 6.1 7 0 0 7 7 7 3 Leucine Rich repeat NACHT PF05729.12 KOO22378.1 - 1.7e-06 28.1 0.1 3.1e-06 27.2 0.1 1.4 1 0 0 1 1 1 1 NACHT domain LRR_4 PF12799.7 KOO22378.1 - 0.0032 17.8 8.6 1.2 9.6 0.0 4.5 4 2 1 5 5 5 2 Leucine Rich repeats (2 copies) AAA_19 PF13245.6 KOO22378.1 - 0.0046 17.3 0.1 0.068 13.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO22378.1 - 0.037 14.3 0.0 0.11 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KOO22378.1 - 0.16 11.1 0.0 0.32 10.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF4244 PF14029.6 KOO22379.1 - 0.067 12.6 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) Flavodoxin_2 PF02525.17 KOO22380.1 - 5.5e-28 98.0 0.0 6.1e-28 97.9 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 KOO22380.1 - 2.2e-12 47.0 0.0 2.8e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase WW PF00397.26 KOO22381.1 - 7.9e-11 41.9 0.2 1.1e-10 41.3 0.2 1.3 1 0 0 1 1 1 1 WW domain PDZ_2 PF13180.6 KOO22381.1 - 0.11 12.8 0.2 0.28 11.5 0.0 1.7 2 0 0 2 2 2 0 PDZ domain GSHPx PF00255.19 KOO22382.1 - 2e-28 98.1 0.0 2.3e-28 97.9 0.0 1.0 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 KOO22382.1 - 0.0096 15.8 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Enolase_C PF00113.22 KOO22383.1 - 9.7e-154 510.9 0.3 1.6e-153 510.2 0.3 1.3 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KOO22383.1 - 2.6e-56 189.4 0.1 5.7e-56 188.3 0.1 1.6 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 KOO22383.1 - 4.9e-11 42.6 0.0 8.6e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 KOO22383.1 - 2.6e-07 30.1 0.1 5.3e-07 29.0 0.1 1.4 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus WD40 PF00400.32 KOO22384.1 - 5.7e-35 118.8 18.6 4.1e-05 24.3 0.6 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat PFU PF09070.11 KOO22384.1 - 7e-31 106.8 0.2 1.3e-30 106.0 0.2 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 KOO22384.1 - 1.3e-27 96.8 6.3 1.9e-27 96.2 6.3 1.2 1 0 0 1 1 1 1 PUL domain BBS2_Mid PF14783.6 KOO22384.1 - 6.1e-05 23.0 0.0 0.35 10.9 0.0 3.4 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Dimerisation PF08100.11 KOO22384.1 - 0.9 9.6 5.4 4.1 7.5 0.4 3.5 3 0 0 3 3 3 0 Dimerisation domain DUF632 PF04782.12 KOO22385.1 - 0.0039 16.6 0.6 0.009 15.4 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF632) SSXT PF05030.12 KOO22385.1 - 0.066 12.9 1.3 7.4 6.3 0.2 2.5 2 0 0 2 2 2 0 SSXT protein (N-terminal region) DUF4470 PF14737.6 KOO22385.1 - 0.08 13.1 0.0 0.21 11.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4470) YebO PF13974.6 KOO22385.1 - 3.5 7.8 12.1 0.13 12.4 2.8 3.1 2 2 1 3 3 3 0 YebO-like protein TIG PF01833.24 KOO22386.1 - 5.1e-153 497.6 54.0 2.1e-08 34.1 0.0 34.1 33 3 0 33 33 33 26 IPT/TIG domain TIG_plexin PF17960.1 KOO22386.1 - 1.8e-30 104.7 0.0 0.39 10.7 0.0 21.5 25 0 0 25 25 25 5 TIG domain fn3 PF00041.21 KOO22386.1 - 0.0011 19.2 0.0 0.0044 17.3 0.0 2.0 1 1 0 1 1 1 1 Fibronectin type III domain PAN_1 PF00024.26 KOO22386.1 - 0.018 15.0 4.4 0.044 13.7 4.4 1.6 1 0 0 1 1 1 0 PAN domain WT1 PF02165.15 KOO22386.1 - 0.12 11.6 2.7 2.3 7.4 0.0 3.8 3 0 0 3 3 3 0 Wilm's tumour protein PAN_4 PF14295.6 KOO22386.1 - 1.5 8.8 3.3 4.2 7.4 3.3 1.7 1 0 0 1 1 1 0 PAN domain IF4E PF01652.18 KOO22387.1 - 2.1e-09 37.4 0.0 2.4e-09 37.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E BT1 PF03092.16 KOO22388.1 - 3.1e-92 309.5 7.8 3.7e-90 302.7 7.8 2.4 1 1 0 1 1 1 1 BT1 family MFS_1 PF07690.16 KOO22388.1 - 6.1e-11 41.9 33.4 9.5e-11 41.2 33.4 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily ThrE_2 PF12821.7 KOO22388.1 - 0.027 14.6 0.4 0.027 14.6 0.4 3.6 5 0 0 5 5 5 0 Threonine/Serine exporter, ThrE Transgly PF00912.22 KOO22388.1 - 0.044 13.2 0.0 0.077 12.5 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase EMP70 PF02990.16 KOO22388.1 - 0.19 10.4 0.7 0.31 9.7 0.7 1.2 1 0 0 1 1 1 0 Endomembrane protein 70 Abhydrolase_1 PF00561.20 KOO22389.1 - 1.9e-15 57.2 0.1 3.3e-10 40.1 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO22389.1 - 5.7e-14 52.0 0.1 4.9e-12 45.6 0.1 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO22389.1 - 2.4e-09 38.1 1.0 5.4e-09 37.0 1.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOO22389.1 - 0.00041 19.9 0.2 0.006 16.1 0.2 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_4 PF08386.10 KOO22389.1 - 0.021 15.0 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein Thioesterase PF00975.20 KOO22389.1 - 0.04 14.0 0.2 0.057 13.5 0.2 1.4 1 1 0 1 1 1 0 Thioesterase domain PhoPQ_related PF10142.9 KOO22389.1 - 0.089 11.4 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein Esterase PF00756.20 KOO22389.1 - 0.15 11.6 0.2 0.23 11.1 0.2 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_2 PF02230.16 KOO22389.1 - 0.18 11.6 0.1 0.8 9.5 0.0 1.9 1 1 2 3 3 3 0 Phospholipase/Carboxylesterase GH3 PF03321.13 KOO22391.1 - 2.3e-110 369.9 0.0 8.9e-109 364.7 0.0 2.0 1 1 0 1 1 1 1 GH3 auxin-responsive promoter Pro_isomerase PF00160.21 KOO22392.1 - 1.2e-38 132.8 0.1 1.4e-38 132.7 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Myb_DNA-binding PF00249.31 KOO22393.1 - 3.8e-25 87.8 0.1 3.3e-11 43.2 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO22393.1 - 4.2e-17 62.1 0.1 8e-08 32.4 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO22393.1 - 3.1e-07 30.2 0.0 0.013 15.3 0.0 2.3 1 1 1 2 2 2 2 Myb DNA-binding like SANT_DAMP1_like PF16282.5 KOO22393.1 - 5.3e-05 23.3 0.1 0.21 11.8 0.0 2.2 1 1 0 2 2 2 2 SANT/Myb-like domain of DAMP1 LRR_1 PF00560.33 KOO22394.1 - 2.2e-06 27.4 0.6 25 5.9 0.0 6.4 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO22394.1 - 7.1e-06 25.7 3.8 22 4.9 0.0 6.4 6 1 0 6 6 6 1 Leucine rich repeat LRR_4 PF12799.7 KOO22394.1 - 1.1e-05 25.7 12.8 11 6.6 0.0 6.7 6 1 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO22394.1 - 0.0014 18.5 23.5 9.4 6.6 0.1 8.8 9 0 0 9 9 9 1 Leucine Rich repeat TetR_N PF00440.23 KOO22394.1 - 0.012 15.4 0.5 11 5.9 0.0 3.7 3 0 0 3 3 3 0 Bacterial regulatory proteins, tetR family Skp1 PF01466.19 KOO22394.1 - 0.012 15.7 0.0 0.092 12.9 0.0 2.5 2 0 0 2 2 2 0 Skp1 family, dimerisation domain HOASN PF14515.6 KOO22394.1 - 0.2 12.1 0.5 7.6 7.0 0.1 3.4 1 1 2 3 3 3 0 Haem-oxygenase-associated N-terminal helices A_deaminase PF00962.22 KOO22395.1 - 2.5e-37 129.0 0.0 3.2e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase MutL_C PF08676.11 KOO22395.1 - 0.0047 16.7 0.1 0.6 9.9 0.0 2.3 2 0 0 2 2 2 2 MutL C terminal dimerisation domain Amidohydro_1 PF01979.20 KOO22395.1 - 0.01 15.2 0.0 0.042 13.2 0.0 1.9 1 1 0 1 1 1 0 Amidohydrolase family EF-hand_1 PF00036.32 KOO22396.1 - 9.2e-11 40.5 4.2 7.3e-05 22.0 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO22396.1 - 7.9e-10 39.1 5.1 3.9e-09 36.8 0.6 3.6 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO22396.1 - 5e-09 35.2 6.9 8.9e-06 25.0 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO22396.1 - 4.4e-08 32.4 2.3 0.0027 17.5 0.0 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO22396.1 - 0.00027 20.7 1.4 1.1 9.2 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair HBS1_N PF08938.10 KOO22396.1 - 0.075 13.4 0.0 5.7 7.3 0.0 3.7 3 1 1 4 4 4 0 HBS1 N-terminus PIF3 PF05006.12 KOO22396.1 - 0.16 12.0 0.0 0.34 11.0 0.0 1.4 1 0 0 1 1 1 0 Per os infectivity factor 3 Sel1 PF08238.12 KOO22397.1 - 2.3e-48 161.5 52.8 8.2e-08 32.7 1.4 11.3 11 0 0 11 11 11 10 Sel1 repeat DUF373 PF04123.13 KOO22397.1 - 0.2 11.1 0.0 0.35 10.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Peptidase_M16_M PF16187.5 KOO22398.1 - 9.1e-33 113.7 0.0 1.5e-32 113.0 0.0 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 KOO22398.1 - 1.2e-27 96.7 0.0 3.5e-27 95.2 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOO22398.1 - 1e-21 77.8 0.0 1.5e-12 47.9 0.0 2.7 3 0 0 3 3 3 2 Peptidase M16 inactive domain Pyr_redox_2 PF07992.14 KOO22399.1 - 9.9e-54 182.6 1.5 1.4e-53 182.1 1.5 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Met_10 PF02475.16 KOO22399.1 - 1.4e-44 152.3 0.0 7.5e-44 149.9 0.0 2.0 1 1 0 1 1 1 1 Met-10+ like-protein Pyr_redox_dim PF02852.22 KOO22399.1 - 1e-32 112.6 0.3 2.6e-32 111.4 0.3 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOO22399.1 - 6.5e-18 65.1 2.3 1.7e-14 54.1 0.1 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO22399.1 - 2e-13 50.3 0.0 9.4e-10 38.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO22399.1 - 3.3e-05 23.1 6.2 0.00062 18.9 0.6 3.1 3 0 0 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 KOO22399.1 - 0.00032 20.2 2.5 0.00056 19.4 2.5 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOO22399.1 - 0.0034 16.2 2.8 0.021 13.5 0.8 2.7 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.19 KOO22399.1 - 0.0047 16.2 4.2 0.14 11.4 0.1 2.5 2 0 0 2 2 2 2 FAD binding domain AlaDh_PNT_C PF01262.21 KOO22399.1 - 0.01 15.1 1.9 0.14 11.4 0.3 2.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 KOO22399.1 - 0.029 14.6 0.6 0.029 14.6 0.6 2.4 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 KOO22399.1 - 0.048 12.8 0.0 0.08 12.1 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 KOO22399.1 - 0.064 12.3 4.7 0.025 13.7 0.9 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 KOO22399.1 - 0.24 10.7 1.3 5.5 6.3 0.1 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 KOO22399.1 - 0.46 10.4 2.3 13 5.6 0.4 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Clat_adaptor_s PF01217.20 KOO22400.1 - 3.7e-23 82.0 2.0 4.3e-23 81.8 2.0 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ADP_ribosyl_GH PF03747.14 KOO22400.1 - 0.046 13.5 0.0 0.054 13.2 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase Methyltransf_21 PF05050.12 KOO22401.1 - 1.2e-05 25.4 0.0 1.4e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain Adeno_E3_CR2 PF02439.15 KOO22401.1 - 0.094 12.5 0.5 0.15 11.8 0.5 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Abhydrolase_1 PF00561.20 KOO22402.1 - 3.5e-27 95.7 0.1 8.4e-27 94.4 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO22402.1 - 5.1e-12 45.6 0.0 2.2e-06 27.1 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO22402.1 - 1.1e-10 42.5 8.7 2e-10 41.7 8.7 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 KOO22402.1 - 0.0067 16.5 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Peptidase_S9 PF00326.21 KOO22402.1 - 0.051 13.0 0.0 0.31 10.5 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family EF-hand_6 PF13405.6 KOO22403.1 - 1.4e-14 52.6 0.0 0.0026 17.5 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO22403.1 - 5.1e-13 47.6 0.0 0.00071 18.9 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO22403.1 - 3e-10 40.4 0.0 4e-07 30.4 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO22403.1 - 3.2e-09 35.9 0.4 0.11 12.0 0.0 3.6 3 0 0 3 3 3 3 EF hand Kelch_3 PF13415.6 KOO22403.1 - 5.4e-09 36.1 0.3 4.4e-07 30.0 0.1 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO22403.1 - 9.1e-07 28.7 0.1 0.034 14.2 0.0 3.4 3 0 0 3 3 3 2 Kelch motif EF-hand_8 PF13833.6 KOO22403.1 - 2.7e-05 23.9 0.2 0.043 13.7 0.0 3.4 2 1 1 3 3 3 1 EF-hand domain pair Kelch_4 PF13418.6 KOO22403.1 - 0.00014 21.8 1.9 0.065 13.2 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO22403.1 - 0.0034 17.6 0.0 5.2 7.5 0.0 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KOO22403.1 - 0.038 14.0 0.0 16 5.7 0.0 2.8 2 0 0 2 2 2 0 Kelch motif Frankia_peptide PF14407.6 KOO22403.1 - 0.12 12.4 0.3 0.87 9.6 0.1 2.6 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Sigma54_activat PF00158.26 KOO22403.1 - 0.12 12.1 0.8 0.25 11.0 0.8 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain EF-hand_9 PF14658.6 KOO22403.1 - 0.27 11.6 1.0 83 3.6 0.0 3.5 4 0 0 4 4 4 0 EF-hand domain FKBP_C PF00254.28 KOO22404.1 - 1.4e-19 70.2 0.0 2.7e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PDZ_6 PF17820.1 KOO22404.1 - 0.00035 20.4 0.0 0.00073 19.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PapD-like PF14874.6 KOO22405.1 - 1.6e-09 37.9 0.1 3e-09 36.9 0.1 1.5 1 0 0 1 1 1 1 Flagellar-associated PapD-like GP24_25 PF17388.2 KOO22406.1 - 0.13 12.2 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Tail assembly gene products 24 & 25 Peptidase_S41 PF03572.18 KOO22406.1 - 0.2 11.2 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S41 PT PF04886.12 KOO22407.1 - 0.0072 15.8 17.0 0.019 14.5 17.0 1.7 1 0 0 1 1 1 1 PT repeat DUF572 PF04502.13 KOO22407.1 - 5.2 6.6 8.1 8.4 5.9 8.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) WD40 PF00400.32 KOO22408.1 - 4.6e-31 106.4 9.4 4.3e-06 27.4 0.0 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO22408.1 - 7.9e-26 90.2 2.6 3.8e-05 23.9 0.1 5.6 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO22408.1 - 8.7e-11 42.1 0.0 0.0003 20.7 0.0 2.9 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KOO22408.1 - 4.6e-06 26.2 0.0 0.0052 16.2 0.0 3.1 3 1 0 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 KOO22408.1 - 3.3e-05 22.6 0.0 0.15 10.6 0.1 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 KOO22408.1 - 0.00088 19.2 0.1 0.018 15.0 0.0 3.1 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 KOO22408.1 - 0.003 16.3 2.0 0.079 11.6 0.1 2.6 2 1 1 3 3 3 1 Nucleoporin Nup120/160 IKI3 PF04762.12 KOO22408.1 - 0.012 13.7 0.5 0.36 8.8 0.3 2.9 2 1 0 2 2 2 0 IKI3 family Coatomer_WDAD PF04053.14 KOO22408.1 - 0.017 14.2 0.0 0.13 11.2 0.0 2.3 1 1 2 3 3 3 0 Coatomer WD associated region Myb_DNA-binding PF00249.31 KOO22409.1 - 8.6e-30 102.7 3.6 6.5e-15 55.1 1.5 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO22409.1 - 1.6e-21 76.3 0.3 5.4e-15 55.4 0.2 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 KOO22409.1 - 5.4e-08 32.9 0.0 0.0031 17.5 0.0 2.2 1 1 1 2 2 2 2 SLIDE Myb_DNA-bind_7 PF15963.5 KOO22409.1 - 0.0044 16.9 0.0 0.019 14.8 0.0 1.9 1 1 1 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 KOO22409.1 - 1.5 9.3 4.9 7 7.1 0.2 2.8 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain DUF2970 PF11174.8 KOO22410.1 - 0.026 14.3 0.8 0.043 13.7 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) Shisa PF13908.6 KOO22410.1 - 0.13 12.5 0.8 0.16 12.2 0.8 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF677 PF05055.12 KOO22410.1 - 3.6 6.4 5.1 4.5 6.1 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) FAP PF07174.11 KOO22410.1 - 5 6.5 26.7 5.7 6.3 26.7 1.0 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) LsmAD PF06741.13 KOO22411.1 - 3.3e-17 62.8 1.9 5.7e-17 62.0 1.9 1.3 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 KOO22411.1 - 1.6e-08 34.6 0.0 3.1e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.15 KOO22411.1 - 0.0036 16.9 0.1 0.0072 15.9 0.1 1.5 1 0 0 1 1 1 1 Ataxin-2 C-terminal region zf-C4H2 PF10146.9 KOO22411.1 - 0.024 15.0 0.0 0.032 14.5 0.0 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein PsbP PF01789.16 KOO22412.1 - 1.5e-14 54.4 0.0 2.2e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 PsbP Arf PF00025.21 KOO22413.1 - 2.8e-29 101.8 0.0 3.8e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOO22413.1 - 6.4e-09 36.1 0.0 1.1e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO22413.1 - 1.5e-06 27.9 0.0 1.7e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 Ras family NACHT PF05729.12 KOO22413.1 - 0.0002 21.3 0.2 0.17 11.8 0.0 2.2 1 1 0 2 2 2 2 NACHT domain G-alpha PF00503.20 KOO22413.1 - 0.00058 19.1 0.1 0.75 8.9 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRP54 PF00448.22 KOO22413.1 - 0.0033 17.1 0.1 0.0071 16.0 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 KOO22413.1 - 0.1 12.5 0.3 0.59 10.0 0.1 2.1 2 0 0 2 2 2 0 NTPase NOG1 PF06858.14 KOO22413.1 - 0.12 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Septin PF00735.18 KOO22413.1 - 0.4 9.9 1.4 0.45 9.8 0.1 1.6 2 0 0 2 2 2 0 Septin PV-1 PF06637.11 KOO22413.1 - 0.49 9.2 5.0 0.68 8.7 5.0 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) PH_6 PF15406.6 KOO22413.1 - 1 9.7 0.0 1 9.7 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain DUF3138 PF11336.8 KOO22413.1 - 1.1 7.8 6.3 1.6 7.3 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Macoilin PF09726.9 KOO22413.1 - 9 4.7 6.7 12 4.3 6.7 1.1 1 0 0 1 1 1 0 Macoilin family PG_isomerase_N PF18353.1 KOO22413.1 - 9 6.7 9.2 2.8 8.4 0.1 3.1 2 1 1 3 3 3 0 Phosphoglucose isomerase N-terminal domain ANAPC4_WD40 PF12894.7 KOO22414.1 - 0.00041 20.6 0.3 0.63 10.4 0.0 3.4 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 KOO22414.1 - 0.012 14.5 0.2 0.019 13.9 0.2 1.2 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain IKI3 PF04762.12 KOO22414.1 - 0.12 10.4 0.1 0.21 9.5 0.1 1.3 1 1 0 1 1 1 0 IKI3 family HSP70 PF00012.20 KOO22416.1 - 3.3e-43 147.8 0.0 3.3e-43 147.8 0.0 3.1 2 1 0 2 2 2 1 Hsp70 protein ParG PF09274.10 KOO22416.1 - 0.027 14.6 0.4 15 5.8 0.0 2.8 3 0 0 3 3 3 0 ParG EF-hand_1 PF00036.32 KOO22417.1 - 2.9e-15 54.6 0.5 2.8e-05 23.4 0.0 4.7 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 KOO22417.1 - 4.4e-15 54.2 2.6 4.6e-06 26.1 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 KOO22417.1 - 2.1e-12 47.3 0.9 3.7e-09 36.9 0.2 3.9 3 1 2 5 5 5 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO22417.1 - 5.3e-12 45.4 0.1 1.4e-07 31.2 0.1 4.4 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO22417.1 - 8.7e-11 40.8 1.9 0.00027 20.3 0.0 4.4 4 0 0 4 4 4 2 EF hand Caleosin PF05042.13 KOO22417.1 - 0.00072 19.5 0.0 0.86 9.5 0.0 3.2 2 1 1 3 3 3 1 Caleosin related protein SHOCT PF09851.9 KOO22417.1 - 0.01 15.5 0.5 4.8 7.1 0.0 3.4 2 1 1 3 3 3 0 Short C-terminal domain LRR_6 PF13516.6 KOO22418.1 - 5.4e-06 26.0 6.3 0.18 12.0 0.1 4.9 5 0 0 5 5 5 2 Leucine Rich repeat Remorin_C PF03763.13 KOO22418.1 - 0.22 11.4 0.1 0.43 10.5 0.1 1.4 1 0 0 1 1 1 0 Remorin, C-terminal region TPR_14 PF13428.6 KOO22420.1 - 1.3e-09 38.1 34.4 0.036 14.9 0.9 10.1 4 3 8 12 12 12 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO22420.1 - 9.3e-09 35.7 12.2 0.0011 19.4 0.1 6.6 7 1 2 9 9 9 3 Tetratricopeptide repeat Suf PF05843.14 KOO22420.1 - 2.3e-05 24.6 0.0 0.016 15.2 0.0 3.1 3 0 0 3 3 3 2 Suppressor of forked protein (Suf) TPR_2 PF07719.17 KOO22420.1 - 0.00096 19.1 14.7 2.2 8.6 0.4 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat FAT PF02259.23 KOO22420.1 - 0.0061 15.8 2.1 2 7.6 0.1 2.5 2 0 0 2 2 2 2 FAT domain TPR_17 PF13431.6 KOO22420.1 - 0.011 16.1 0.2 1.5e+02 3.1 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO22420.1 - 0.039 14.6 19.4 4.3 8.1 0.4 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF3703 PF12487.8 KOO22420.1 - 0.82 9.5 5.1 3.3 7.6 0.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3703) TPR_9 PF13371.6 KOO22420.1 - 0.87 9.8 11.0 16 5.7 0.1 4.6 2 2 2 4 4 4 0 Tetratricopeptide repeat DSHCT PF08148.12 KOO22421.1 - 9e-45 152.3 0.1 1.8e-43 148.1 0.0 2.4 2 0 0 2 2 2 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 KOO22421.1 - 5e-30 105.3 0.0 1e-29 104.3 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 KOO22421.1 - 1.8e-16 60.4 0.0 3.7e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO22421.1 - 5.9e-07 29.8 0.0 1.4e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO22421.1 - 3.5e-06 27.1 0.0 5.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOO22421.1 - 0.015 15.6 0.1 0.066 13.5 0.0 2.2 3 0 0 3 3 3 0 AAA domain SSI PF00720.17 KOO22421.1 - 0.13 12.3 1.1 0.97 9.4 0.2 2.6 2 0 0 2 2 2 0 Subtilisin inhibitor-like LRR_4 PF12799.7 KOO22422.1 - 0.21 12.1 13.5 4.2 7.9 0.9 5.2 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO22422.1 - 2.6 8.3 24.4 3.2 8.0 0.1 8.1 9 0 0 9 9 9 0 Leucine Rich repeat LRR_8 PF13855.6 KOO22422.1 - 8.3 6.3 11.9 3.9 7.3 1.8 4.8 5 0 0 5 5 5 0 Leucine rich repeat Band_7 PF01145.25 KOO22423.1 - 5.3e-31 108.0 1.1 5.3e-31 108.0 1.1 1.7 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 KOO22423.1 - 3e-23 81.7 2.1 3e-23 81.7 2.1 1.9 2 0 0 2 2 2 1 C-terminal region of band_7 EF-hand_1 PF00036.32 KOO22423.1 - 1.5e-09 36.7 0.2 0.00049 19.5 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO22423.1 - 5.9e-09 35.2 0.2 0.0043 16.9 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO22423.1 - 1.2e-08 34.7 0.8 1.4e-05 24.9 0.1 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO22423.1 - 1.4e-08 35.1 0.0 2.7e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO22423.1 - 1e-07 31.1 0.4 0.0026 17.2 0.1 2.4 2 0 0 2 2 2 2 EF hand Band_7_1 PF13421.6 KOO22423.1 - 0.019 14.7 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family Beta_helix PF13229.6 KOO22424.1 - 3.2e-30 105.1 2.4 1.4e-14 54.3 0.9 3.7 2 1 1 3 3 3 3 Right handed beta helix region cNMP_binding PF00027.29 KOO22424.1 - 1.4e-29 102.0 0.1 2.2e-14 53.3 0.1 3.7 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Pkinase PF00069.25 KOO22424.1 - 3.7e-23 82.2 0.0 6.1e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain NosD PF05048.13 KOO22424.1 - 1.2e-19 70.6 0.0 1.5e-07 30.9 0.0 3.4 1 1 1 3 3 3 3 Periplasmic copper-binding protein (NosD) Ax_dynein_light PF10211.9 KOO22424.1 - 7.2e-08 32.6 1.8 7.2e-08 32.6 1.8 1.8 2 0 0 2 2 2 1 Axonemal dynein light chain Pkinase_Tyr PF07714.17 KOO22424.1 - 0.00045 19.6 0.0 0.00084 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TetR_C_11 PF16859.5 KOO22424.1 - 0.019 15.2 3.7 11 6.3 0.2 4.3 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain MgtE_N PF03448.17 KOO22424.1 - 2.3 8.9 6.7 29 5.4 0.1 3.8 3 1 1 4 4 4 0 MgtE intracellular N domain Patched PF02460.18 KOO22425.1 - 1.1e-05 23.7 0.1 1.8e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 KOO22425.1 - 2.2 8.1 11.7 0.056 13.3 3.7 2.4 2 0 0 2 2 2 0 Sterol-sensing domain of SREBP cleavage-activation RRM_1 PF00076.22 KOO22428.1 - 3.2e-11 42.9 0.2 9.5e-10 38.2 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 KOO22428.1 - 4e-06 27.0 0.0 7.9e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 PWI domain RRM_occluded PF16842.5 KOO22428.1 - 0.0076 16.1 0.1 0.027 14.3 0.0 2.0 2 0 0 2 2 2 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KOO22428.1 - 0.013 15.5 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Adeno_PV PF03910.13 KOO22428.1 - 0.13 10.9 3.1 0.22 10.2 3.1 1.3 1 0 0 1 1 1 0 Adenovirus minor core protein PV Amidase PF01425.21 KOO22429.1 - 1.1e-77 262.0 1.7 1.2e-77 261.8 1.7 1.0 1 0 0 1 1 1 1 Amidase Ion_trans PF00520.31 KOO22430.1 - 4.5e-195 645.0 42.4 1.8e-56 191.1 0.2 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO22430.1 - 2.4e-07 30.4 0.0 5.5e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO22430.1 - 0.0035 16.1 2.0 0.0035 16.1 2.0 9.8 9 2 2 11 11 11 5 Polycystin cation channel UPF0542 PF15086.6 KOO22430.1 - 2.6 8.0 7.6 0.11 12.4 0.5 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 Pkinase PF00069.25 KOO22431.1 - 7.5e-08 32.0 0.0 1.3e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22431.1 - 1e-07 31.5 0.0 2.4e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO22431.1 - 5e-06 26.0 0.0 1.1e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like HEAT PF02985.22 KOO22431.1 - 4.1e-05 23.5 1.9 1.5 9.3 0.0 4.6 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 KOO22431.1 - 0.0043 17.5 0.9 11 6.6 0.0 4.5 4 0 0 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 KOO22431.1 - 0.011 15.8 0.6 0.14 12.2 0.2 2.7 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KOO22431.1 - 0.078 13.6 0.2 3.9 8.1 0.0 3.0 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region ShK PF01549.24 KOO22432.1 - 2e-19 69.8 38.1 2.1e-08 34.6 8.9 3.8 3 0 0 3 3 3 3 ShK domain-like 2OG-FeII_Oxy_3 PF13640.6 KOO22432.1 - 6.5e-15 55.8 0.0 1.6e-14 54.5 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ORF_12_N PF18042.1 KOO22432.1 - 0.22 12.0 0.0 5.6 7.4 0.0 2.2 2 0 0 2 2 2 0 ORF 12 gene product N-terminal LRR_6 PF13516.6 KOO22433.1 - 2.4e-14 52.1 20.8 0.0018 18.2 0.2 6.9 7 0 0 7 7 7 5 Leucine Rich repeat HOASN PF14515.6 KOO22433.1 - 1.3 9.4 4.9 13 6.2 0.4 3.1 2 2 1 3 3 3 0 Haem-oxygenase-associated N-terminal helices LRR_4 PF12799.7 KOO22433.1 - 4.9 7.7 15.5 14 6.3 1.7 4.5 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) H_PPase PF03030.16 KOO22434.1 - 4.4e-133 445.2 22.7 5.2e-133 445.0 22.7 1.0 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase COMM_domain PF07258.14 KOO22435.1 - 1.7e-08 34.5 0.0 2.3e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 COMM domain PRA1 PF03208.19 KOO22438.1 - 1.7e-20 73.1 0.2 2.1e-20 72.8 0.2 1.1 1 0 0 1 1 1 1 PRA1 family protein UBA PF00627.31 KOO22438.1 - 8.7e-07 28.7 0.2 1.5e-06 28.0 0.2 1.4 1 0 0 1 1 1 1 UBA/TS-N domain HTH_8 PF02954.19 KOO22438.1 - 0.0082 15.9 0.7 0.016 15.0 0.7 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family HOIP-UBA PF16678.5 KOO22438.1 - 0.11 12.5 0.4 0.17 11.9 0.4 1.2 1 0 0 1 1 1 0 HOIP UBA domain pair BACK PF07707.15 KOO22439.1 - 6e-20 71.3 1.8 8.5e-20 70.8 1.8 1.2 1 0 0 1 1 1 1 BTB And C-terminal Kelch 2OG-FeII_Oxy_3 PF13640.6 KOO22440.1 - 1.4e-08 35.5 0.1 4.7e-08 33.8 0.1 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF4586 PF15239.6 KOO22442.1 - 8.3e-48 164.1 17.4 1e-47 163.8 17.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) DUF5033 PF16436.5 KOO22443.1 - 0.09 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5033) DUF730 PF05325.11 KOO22443.1 - 0.14 12.2 3.3 0.44 10.6 1.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF730) His_biosynth PF00977.21 KOO22445.1 - 1.6e-45 155.4 0.8 1.1e-44 152.7 0.8 2.4 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 KOO22445.1 - 2.6e-23 82.8 0.0 3.8e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 KOO22445.1 - 3.9e-08 33.1 0.0 6.5e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 KOO22445.1 - 9.4e-07 28.9 0.0 1.3e-05 25.1 0.0 2.2 1 1 0 1 1 1 1 SNO glutamine amidotransferase family Peptidase_C26 PF07722.13 KOO22445.1 - 0.01 15.6 0.1 0.23 11.2 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 ThiG PF05690.14 KOO22445.1 - 1 8.6 3.6 0.34 10.2 0.2 1.9 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG TPR_2 PF07719.17 KOO22446.1 - 2.6e-06 27.1 6.5 0.0088 16.1 0.2 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO22446.1 - 8.3e-06 25.4 6.7 0.0077 16.0 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22446.1 - 1.6e-05 25.3 3.6 0.0031 18.2 0.1 3.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO22446.1 - 3.6e-05 24.3 9.0 0.0073 16.9 0.2 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO22446.1 - 6e-05 23.2 0.4 0.0016 18.7 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO22446.1 - 0.00058 19.5 0.7 0.061 13.0 0.1 2.5 2 0 0 2 2 2 1 TPR repeat TPR_19 PF14559.6 KOO22446.1 - 0.0036 17.8 3.6 0.19 12.2 0.5 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO22446.1 - 0.0054 16.9 0.6 0.012 15.7 0.6 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO22446.1 - 0.025 14.8 2.2 7 7.1 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO22446.1 - 0.084 12.9 0.3 2.9 8.1 0.1 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO22446.1 - 0.086 13.1 2.2 1.4 9.3 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Gly_radical PF01228.21 KOO22446.1 - 0.15 12.6 0.1 1.1 9.8 0.1 2.1 1 1 1 2 2 2 0 Glycine radical zf-CCHH PF10283.9 KOO22446.1 - 2.3 8.3 10.4 1.2 9.2 1.3 3.1 3 0 0 3 3 3 0 PBZ domain EF-hand_1 PF00036.32 KOO22447.1 - 0.013 15.0 0.3 0.05 13.2 0.1 2.0 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 KOO22447.1 - 0.017 15.0 0.1 0.19 11.7 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain KIAA1430 PF13879.6 KOO22447.1 - 0.018 15.8 0.1 0.018 15.8 0.1 2.6 2 1 0 2 2 2 0 KIAA1430 homologue Vma12 PF11712.8 KOO22447.1 - 0.079 13.0 0.1 0.33 11.0 0.0 2.1 2 2 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase AKAP2_C PF15304.6 KOO22448.1 - 0.00074 18.9 1.1 0.011 15.1 0.1 2.0 1 1 0 2 2 2 2 A-kinase anchor protein 2 C-terminus TetR_C_28 PF17937.1 KOO22448.1 - 0.15 12.5 2.6 1.3 9.5 0.0 2.7 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Trehalase PF01204.18 KOO22449.1 - 0.0034 16.3 0.0 0.005 15.7 0.0 1.1 1 0 0 1 1 1 1 Trehalase Stn1_C PF12659.7 KOO22449.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 Telomere capping C-terminal wHTH TetR_C_28 PF17937.1 KOO22449.1 - 1.3 9.5 5.1 2.5 8.6 0.0 3.3 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain Asp_protease_2 PF13650.6 KOO22450.1 - 0.00011 22.7 0.0 0.00026 21.5 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KOO22450.1 - 0.0017 18.9 0.7 0.0078 16.8 0.1 2.0 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease EF-hand_6 PF13405.6 KOO22451.1 - 1.5e-27 93.1 5.3 0.0018 18.1 0.0 7.8 8 0 0 8 8 8 6 EF-hand domain EF-hand_1 PF00036.32 KOO22451.1 - 2.3e-26 89.3 0.8 0.00041 19.7 0.2 7.6 7 1 0 7 7 7 6 EF hand EF-hand_7 PF13499.6 KOO22451.1 - 2.4e-25 88.8 0.3 1.1e-10 41.8 0.3 5.2 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO22451.1 - 4.5e-19 67.0 3.8 0.0037 16.7 0.0 6.5 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO22451.1 - 5.1e-19 67.9 3.3 3e-09 36.6 0.4 5.6 5 2 1 6 6 6 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO22451.1 - 0.0017 18.6 0.0 0.49 10.7 0.0 3.7 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO22451.1 - 0.0052 16.6 2.9 9.6 6.2 0.0 4.3 4 1 1 5 5 5 1 EF hand EF-hand_9 PF14658.6 KOO22451.1 - 0.0064 16.8 0.1 0.47 10.8 0.0 3.3 4 0 0 4 4 4 1 EF-hand domain FlxA PF14282.6 KOO22452.1 - 0.13 12.2 3.5 3.1 7.8 0.5 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF3761 PF12587.8 KOO22452.1 - 0.18 12.2 0.2 29 5.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) DUF1666 PF07891.12 KOO22452.1 - 2.2 7.9 5.8 3.1 7.4 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1666) Epimerase PF01370.21 KOO22454.1 - 4.5e-16 59.0 0.0 6.3e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO22454.1 - 1.9e-13 50.5 0.0 3.7e-13 49.6 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KOO22454.1 - 8.7e-08 31.6 0.0 4.1e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 KOO22454.1 - 1.4e-06 27.5 0.0 3.7e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KOO22454.1 - 0.00085 18.5 0.0 0.0018 17.4 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 KOO22454.1 - 0.0084 16.0 0.6 0.23 11.3 0.6 2.3 2 0 0 2 2 2 1 KR domain PI3Ka PF00613.20 KOO22456.1 - 1.4e-58 197.4 0.1 2.7e-58 196.4 0.1 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 KOO22456.1 - 1.3e-48 166.1 0.0 2.3e-47 161.9 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase cNMP_binding PF00027.29 KOO22456.1 - 7.4e-14 51.6 0.1 1.5e-06 28.1 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DUF4135 PF13575.6 KOO22456.1 - 0.014 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) VGPC1_C PF16799.5 KOO22456.1 - 0.17 11.9 0.7 0.4 10.7 0.7 1.6 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 TPR_11 PF13414.6 KOO22458.1 - 9.2e-05 22.1 4.6 0.13 12.0 0.5 2.3 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.6 KOO22458.1 - 0.00011 22.5 2.1 0.3 11.4 0.6 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO22458.1 - 0.0014 18.6 9.1 0.016 15.2 2.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO22458.1 - 0.0025 17.6 8.7 0.0033 17.2 1.4 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO22458.1 - 0.027 14.9 0.8 2.9 8.5 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO22458.1 - 0.17 12.1 2.8 0.3 11.3 2.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 KOO22458.1 - 0.7 10.9 4.7 0.88 10.6 1.7 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat RNase_PH_C PF03725.15 KOO22461.1 - 2e-06 27.8 0.0 2.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Ribonuc_red_lgC PF02867.15 KOO22462.1 - 1.3e-178 594.9 0.0 1.5e-178 594.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 KOO22462.1 - 8.9e-22 76.9 0.0 2.3e-21 75.6 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain Engrail_1_C_sig PF10525.9 KOO22462.1 - 0.044 13.0 0.1 0.1 11.9 0.1 1.5 1 0 0 1 1 1 0 Engrailed homeobox C-terminal signature domain HTH_23 PF13384.6 KOO22463.1 - 0.0003 20.5 0.1 0.44 10.4 0.0 3.0 4 0 0 4 4 4 2 Homeodomain-like domain HTH_29 PF13551.6 KOO22463.1 - 0.00098 19.1 0.2 0.043 13.8 0.0 2.8 2 1 0 2 2 2 1 Winged helix-turn helix HTH_32 PF13565.6 KOO22463.1 - 0.0062 17.1 0.0 0.019 15.6 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 KOO22463.1 - 0.041 14.0 0.0 0.26 11.4 0.0 2.3 2 1 0 2 2 2 0 Helix-turn-helix domain DUF16 PF01519.16 KOO22464.1 - 5.5 7.5 7.5 35 4.9 7.5 2.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 Na_Ca_ex PF01699.24 KOO22465.1 - 6e-42 143.2 33.4 3.3e-22 79.1 16.3 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Calx-beta PF03160.14 KOO22465.1 - 1.2e-19 70.4 0.0 4.2e-17 62.2 0.0 2.6 2 0 0 2 2 2 2 Calx-beta domain Na_Ca_ex_C PF16494.5 KOO22465.1 - 0.27 11.7 0.4 0.48 10.9 0.4 1.3 1 0 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain Glyco_hydro_127 PF07944.12 KOO22466.1 - 3.1e-39 134.9 0.0 3.9e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Sulfotransfer_3 PF13469.6 KOO22467.1 - 0.0048 17.3 0.0 0.013 15.9 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family adh_short PF00106.25 KOO22468.1 - 1.6e-20 73.4 0.0 2.7e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO22468.1 - 4.7e-15 55.8 0.0 7.5e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO22468.1 - 2.4e-06 27.6 0.2 6.5e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 KOO22468.1 - 4.7e-05 23.0 0.0 8.1e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOO22468.1 - 0.0012 18.0 0.8 0.0016 17.6 0.0 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain ADH_zinc_N PF00107.26 KOO22468.1 - 0.0039 17.2 0.1 0.0095 15.9 0.1 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Oxidored_nitro PF00148.19 KOO22468.1 - 0.0076 15.0 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase NAD_binding_10 PF13460.6 KOO22468.1 - 0.03 14.2 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding NAD_binding_7 PF13241.6 KOO22468.1 - 0.079 13.4 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF309 PF03745.14 KOO22468.1 - 0.093 12.4 0.4 0.22 11.2 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF309) zf-C2HC_2 PF13913.6 KOO22469.1 - 1.2e-13 50.5 12.8 4.8e-08 32.7 2.4 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type TIP39 PF14980.6 KOO22469.1 - 0.042 13.7 2.1 0.12 12.2 2.1 1.8 1 0 0 1 1 1 0 TIP39 peptide zf-CpG_bind_C PF12269.8 KOO22469.1 - 0.07 12.9 2.4 0.09 12.6 0.1 1.9 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain zf-C2H2_4 PF13894.6 KOO22469.1 - 8.9 7.5 8.4 4.2 8.5 0.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Histone_HNS PF00816.21 KOO22470.1 - 0.0026 18.5 3.0 0.31 11.9 0.4 2.2 1 1 1 2 2 2 2 H-NS histone family MerR-DNA-bind PF09278.11 KOO22470.1 - 0.036 14.6 0.9 0.094 13.3 0.1 1.9 2 0 0 2 2 2 0 MerR, DNA binding Methyltransf_23 PF13489.6 KOO22471.1 - 4.5e-05 23.4 0.0 7.4e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO22471.1 - 0.076 13.7 0.0 0.2 12.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Synuclein PF01387.17 KOO22471.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Synuclein AP3D1 PF06375.11 KOO22472.1 - 0.039 14.2 0.1 0.054 13.7 0.1 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4710 PF15828.5 KOO22472.1 - 0.067 13.3 1.5 0.67 10.1 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) DUF3235 PF11574.8 KOO22472.1 - 0.52 11.2 2.3 39 5.2 2.3 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3235) YL1 PF05764.13 KOO22473.1 - 0.98 9.5 23.4 0.23 11.5 20.0 1.6 2 0 0 2 2 2 0 YL1 nuclear protein TauD PF02668.16 KOO22474.1 - 7.9e-34 117.7 0.0 1.1e-33 117.2 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Aldo_ket_red PF00248.21 KOO22474.1 - 8e-09 35.1 0.0 1.3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family ABC2_membrane_3 PF12698.7 KOO22476.1 - 3.4e-44 151.4 26.0 1.8e-27 96.4 1.9 3.3 3 0 0 3 3 3 2 ABC-2 family transporter protein ABC_tran PF00005.27 KOO22476.1 - 3.6e-44 150.6 0.0 7.9e-21 75.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO22476.1 - 1.9e-20 73.9 0.1 2.3e-08 34.2 0.0 4.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SRCR PF00530.18 KOO22476.1 - 5.8e-15 55.6 0.2 1.5e-14 54.3 0.2 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SMC_N PF02463.19 KOO22476.1 - 0.00011 21.7 0.0 0.41 10.0 0.0 3.4 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOO22476.1 - 0.00036 21.1 0.3 0.21 12.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 KOO22476.1 - 0.0049 17.1 0.0 13 6.0 0.0 4.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF4162 PF13732.6 KOO22476.1 - 0.0084 16.8 0.0 5 7.9 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_30 PF13604.6 KOO22476.1 - 0.023 14.4 0.1 1.5 8.5 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_27 PF13514.6 KOO22476.1 - 0.049 13.2 0.1 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 KOO22476.1 - 0.16 11.6 0.2 20 4.7 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_15 PF13175.6 KOO22476.1 - 0.36 10.5 0.7 1.7 8.3 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain MukB PF04310.12 KOO22476.1 - 0.36 10.6 1.5 4.9 6.9 0.1 2.6 3 0 0 3 3 3 0 MukB N-terminal AAA_29 PF13555.6 KOO22476.1 - 4.3 7.2 5.4 8.6 6.2 0.1 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain DAGK_acc PF00609.19 KOO22477.1 - 0.11 12.9 1.2 0.48 10.8 0.3 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase accessory domain Cas_DxTHG PF09455.10 KOO22477.1 - 5.4 6.5 8.6 6.8 6.2 8.6 1.3 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family ATP-synt_B PF00430.18 KOO22478.1 - 0.29 11.2 12.3 0.26 11.4 11.5 1.4 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) DUF4140 PF13600.6 KOO22479.1 - 0.032 14.7 3.2 0.032 14.7 3.2 6.2 3 1 2 5 5 5 0 N-terminal domain of unknown function (DUF4140) HsbA PF12296.8 KOO22479.1 - 0.036 14.5 0.2 0.17 12.3 0.2 2.3 1 0 0 1 1 1 0 Hydrophobic surface binding protein A DnaJ_C PF01556.18 KOO22481.1 - 3.4e-23 82.4 0.0 4.8e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOO22481.1 - 2.2e-19 69.3 0.0 3.3e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain PI3K_P85_iSH2 PF16454.5 KOO22482.1 - 0.011 15.4 7.1 0.29 10.7 6.9 2.4 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GAS PF13851.6 KOO22482.1 - 0.092 12.1 29.0 0.27 10.6 21.3 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 KOO22482.1 - 0.32 11.2 55.8 0.035 14.3 15.1 2.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) ABC_tran_CTD PF16326.5 KOO22482.1 - 0.35 11.2 0.1 0.35 11.2 0.1 6.1 2 1 4 6 6 6 0 ABC transporter C-terminal domain TruB_N PF01509.18 KOO22482.1 - 2.3 8.6 8.9 5.5 7.3 0.9 2.4 1 1 1 2 2 2 0 TruB family pseudouridylate synthase (N terminal domain) Fez1 PF06818.15 KOO22482.1 - 7.4 7.0 32.8 10 6.5 12.5 3.1 1 1 2 3 3 3 0 Fez1 Importin_rep_4 PF18808.1 KOO22483.1 - 1.6e-22 79.6 1.7 1.6e-22 79.6 1.7 4.7 5 0 0 5 5 5 1 Importin repeat HEAT PF02985.22 KOO22483.1 - 9.2e-19 65.9 11.8 0.00036 20.6 0.0 11.5 14 0 0 14 14 13 4 HEAT repeat HEAT_2 PF13646.6 KOO22483.1 - 4.1e-16 59.1 14.4 2.4e-07 31.1 0.0 8.6 5 3 3 9 9 8 2 HEAT repeats HEAT_EZ PF13513.6 KOO22483.1 - 3.2e-14 53.1 22.2 0.0026 18.2 0.0 11.1 8 3 3 11 11 11 4 HEAT-like repeat Vac14_Fab1_bd PF12755.7 KOO22483.1 - 3e-08 34.1 0.0 0.08 13.5 0.0 6.3 5 2 2 7 7 7 1 Vacuolar 14 Fab1-binding region Importin_rep_6 PF18829.1 KOO22483.1 - 3.4e-06 27.1 1.1 2.1e-05 24.6 0.0 2.8 3 0 0 3 3 3 1 Importin repeat 6 Cnd1 PF12717.7 KOO22483.1 - 1.3e-05 25.4 3.1 0.12 12.4 0.0 4.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 KOO22483.1 - 2.3e-05 23.7 0.2 0.2 10.7 0.0 5.5 3 1 3 6 6 6 1 RNAPII transcription regulator C-terminal Tti2 PF10521.9 KOO22483.1 - 0.00019 21.1 0.0 0.49 9.9 0.0 4.1 4 1 1 5 5 5 1 Tti2 family RTP1_C1 PF10363.9 KOO22483.1 - 0.00029 21.0 0.1 0.39 10.9 0.0 4.2 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RIX1 PF08167.12 KOO22483.1 - 0.0022 17.8 0.1 0.82 9.4 0.0 4.4 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis DUF3385 PF11865.8 KOO22483.1 - 0.003 17.5 0.8 19 5.1 0.0 5.5 5 2 1 6 6 6 0 Domain of unknown function (DUF3385) TFCD_C PF12612.8 KOO22483.1 - 0.012 15.5 2.4 7.5 6.3 0.0 4.6 4 2 0 4 4 4 0 Tubulin folding cofactor D C terminal Cohesin_HEAT PF12765.7 KOO22483.1 - 0.02 15.2 0.0 9.1 6.7 0.0 3.3 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion IBN_N PF03810.19 KOO22483.1 - 0.021 14.8 0.3 0.44 10.5 0.1 3.2 2 0 0 2 2 2 0 Importin-beta N-terminal domain HEAT_PBS PF03130.16 KOO22483.1 - 0.078 13.7 6.1 8.2 7.4 1.0 5.7 4 1 0 4 4 3 0 PBS lyase HEAT-like repeat Arm PF00514.23 KOO22483.1 - 0.37 10.9 9.5 34 4.7 0.1 6.9 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 KOO22483.1 - 0.81 9.2 9.1 2.5 7.6 0.0 4.6 5 1 0 5 5 5 0 CLASP N terminal EF-hand_6 PF13405.6 KOO22485.1 - 6e-17 60.1 0.0 0.022 14.7 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO22485.1 - 8.2e-15 53.2 0.1 0.0075 15.7 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO22485.1 - 1.3e-14 54.4 0.1 8.9e-06 26.1 0.0 3.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO22485.1 - 7.2e-12 45.0 0.1 0.0023 17.8 0.0 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO22485.1 - 1.1e-06 27.8 0.7 3.6 7.2 0.0 4.7 4 0 0 4 4 4 4 EF hand Thymopoietin PF08198.11 KOO22485.1 - 2.3 7.9 4.3 10 5.8 0.1 4.0 3 2 1 4 4 4 0 Thymopoietin protein DUF4205 PF13898.6 KOO22487.1 - 3.9e-46 157.6 0.0 7.3e-45 153.4 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4205) EF-hand_1 PF00036.32 KOO22487.1 - 0.011 15.3 0.0 0.054 13.1 0.0 2.2 3 0 0 3 3 3 0 EF hand EF-hand_9 PF14658.6 KOO22487.1 - 0.016 15.5 0.0 0.046 14.0 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_6 PF13405.6 KOO22487.1 - 0.043 13.7 0.0 0.2 11.6 0.0 2.1 3 0 0 3 3 3 0 EF-hand domain GHMP_kinases_C PF08544.13 KOO22487.1 - 0.084 13.2 1.0 1.3 9.5 0.0 2.8 2 0 0 2 2 2 0 GHMP kinases C terminal COX5B PF01215.19 KOO22488.1 - 1.8e-06 27.7 0.0 3.2e-06 26.8 0.0 1.5 2 0 0 2 2 2 1 Cytochrome c oxidase subunit Vb zf-ZPR1 PF03367.13 KOO22489.1 - 2.6e-14 53.4 0.0 3.8e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 ZPR1 zinc-finger domain YjgF_endoribonc PF14588.6 KOO22491.1 - 4.5e-26 91.8 0.0 5e-26 91.6 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 KOO22491.1 - 3.1e-17 62.7 0.0 4.4e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP Ank_2 PF12796.7 KOO22492.1 - 6.4e-25 87.6 0.2 1e-09 38.9 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) 2OG-FeII_Oxy PF03171.20 KOO22492.1 - 1e-13 51.6 0.0 2.2e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 KOO22492.1 - 1.3e-13 51.8 0.0 2.1e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Ank PF00023.30 KOO22492.1 - 6.6e-11 42.1 1.3 0.00031 21.1 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KOO22492.1 - 1.2e-10 41.7 0.0 2.7e-06 27.8 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO22492.1 - 4.3e-09 36.5 0.2 1.2e-07 31.8 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22492.1 - 7.3e-06 26.0 0.1 0.05 14.2 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Hist_deacetyl PF00850.19 KOO22493.1 - 1.8e-48 165.6 1.3 4.9e-48 164.2 1.3 1.7 1 1 0 1 1 1 1 Histone deacetylase domain Optomotor-blind PF11078.8 KOO22493.1 - 1.6 9.4 6.4 0.39 11.3 3.1 1.7 2 0 0 2 2 2 0 Optomotor-blind protein N-terminal region mRNA_cap_enzyme PF01331.19 KOO22495.1 - 4.2e-13 49.6 0.0 4.9e-13 49.3 0.0 1.0 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DNA_ligase_A_M PF01068.21 KOO22495.1 - 0.052 13.2 0.0 0.067 12.8 0.0 1.2 1 0 0 1 1 1 0 ATP dependent DNA ligase domain Img2 PF05046.14 KOO22496.1 - 2.2e-19 69.5 0.0 2.8e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SUI1 PF01253.22 KOO22496.1 - 0.0076 16.7 0.0 0.011 16.3 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 LRR_6 PF13516.6 KOO22497.1 - 4.8e-21 73.0 9.9 0.088 12.9 0.3 9.1 9 0 0 9 9 9 7 Leucine Rich repeat LRR_4 PF12799.7 KOO22497.1 - 0.0011 19.4 2.9 1.6 9.2 0.1 3.8 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) Hairy_orange PF07527.13 KOO22497.1 - 0.13 12.5 0.1 0.39 11.0 0.1 1.9 1 0 0 1 1 1 0 Hairy Orange PRIMA1 PF16101.5 KOO22497.1 - 0.19 11.7 7.5 0.54 10.3 7.5 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 LRR_1 PF00560.33 KOO22497.1 - 0.28 11.9 1.5 4.5e+02 2.1 0.1 5.0 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO22497.1 - 0.45 10.3 9.4 3.8 7.3 1.6 3.6 3 1 1 4 4 4 0 Leucine rich repeat WD40 PF00400.32 KOO22498.1 - 2.9e-33 113.3 12.4 4.7e-08 33.6 0.1 7.5 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO22498.1 - 2e-12 47.2 0.0 0.018 15.3 0.0 4.3 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO22498.1 - 7.8e-09 34.9 0.2 0.00066 18.7 0.0 3.3 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KOO22498.1 - 0.0004 19.8 0.0 1.1 8.5 0.0 2.9 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 KOO22498.1 - 0.0098 14.6 0.0 8 5.0 0.0 3.1 2 1 0 3 3 3 2 Nucleoporin Nup120/160 PKD PF00801.20 KOO22498.1 - 0.27 11.1 3.4 10 6.1 0.2 3.3 2 1 1 3 3 3 0 PKD domain PKcGMP_CC PF16808.5 KOO22499.1 - 0.095 12.6 15.3 2.9 7.8 1.5 4.2 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Nup54_C PF18437.1 KOO22499.1 - 0.45 10.5 1.6 37 4.3 0.1 2.7 2 1 0 2 2 2 0 Nup54 C-terminal interacting domain Atg14 PF10186.9 KOO22499.1 - 0.5 9.4 6.0 0.67 9.0 6.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Hamartin PF04388.12 KOO22499.1 - 6.9 5.2 20.6 15 4.1 20.6 1.4 1 1 0 1 1 1 0 Hamartin protein RHD3 PF05879.12 KOO22500.1 - 0.0023 16.2 0.0 0.003 15.8 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) RMMBL PF07521.12 KOO22502.1 - 0.16 11.9 0.5 8.8 6.3 0.2 2.6 2 0 0 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain PNPase PF03726.14 KOO22502.1 - 0.89 10.1 8.1 0.38 11.3 1.0 2.8 2 1 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Anoctamin PF04547.12 KOO22503.1 - 9.7e-101 337.8 0.0 1.6e-100 337.1 0.0 1.3 1 1 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KOO22503.1 - 7e-07 29.2 0.0 4.9e-06 26.4 0.0 2.4 2 1 0 2 2 2 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin MerC PF03203.14 KOO22503.1 - 4.5 7.7 5.8 0.57 10.7 0.6 2.3 2 0 0 2 2 2 0 MerC mercury resistance protein DnaJ PF00226.31 KOO22504.1 - 1.3e-14 54.1 0.6 4.1e-14 52.5 0.2 2.1 2 1 0 2 2 2 1 DnaJ domain Hormone_3 PF00159.18 KOO22504.1 - 0.094 12.8 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Pancreatic hormone peptide HSP90 PF00183.18 KOO22505.1 - 6.9e-102 342.0 0.0 2.1e-99 333.8 0.0 2.0 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 KOO22505.1 - 2e-13 50.3 0.3 3.8e-13 49.5 0.3 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOO22505.1 - 2.5e-10 40.8 0.1 4.8e-10 39.9 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ATP-synt_C PF00137.21 KOO22507.1 - 1.4e-32 111.8 39.1 2.3e-19 69.5 17.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C EF-hand_6 PF13405.6 KOO22510.1 - 3.5e-05 23.4 0.2 0.00017 21.3 0.2 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO22510.1 - 0.00026 20.3 0.1 0.00077 18.8 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO22510.1 - 0.0027 17.1 0.3 0.0077 15.7 0.3 1.8 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO22510.1 - 0.0034 17.8 0.1 0.0071 16.8 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair DUF1772 PF08592.11 KOO22510.1 - 0.06 13.7 0.9 1.7 8.9 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) UT PF03253.14 KOO22511.1 - 2.8e-57 194.1 32.1 4.4e-57 193.4 32.1 1.2 1 0 0 1 1 1 1 Urea transporter Methyltransf_25 PF13649.6 KOO22511.1 - 5.2e-07 30.3 0.1 3.1e-06 27.8 0.1 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO22511.1 - 0.027 14.3 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Rsm22 PF09243.10 KOO22511.1 - 0.19 11.0 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 FAA_hydrolase PF01557.18 KOO22513.1 - 1.3e-51 175.4 0.0 1.6e-51 175.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family TPR_2 PF07719.17 KOO22515.1 - 0.00022 21.1 2.1 0.049 13.8 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO22515.1 - 0.0026 17.5 0.0 0.011 15.6 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO22515.1 - 0.0027 18.0 0.3 0.037 14.4 0.2 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO22515.1 - 0.024 15.3 13.5 0.027 15.1 3.9 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22515.1 - 0.024 15.4 16.7 0.029 15.2 2.2 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat Regnase_1_C PF18561.1 KOO22515.1 - 0.069 12.9 0.1 1.5 8.6 0.0 2.6 2 0 0 2 2 2 0 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain TPR_19 PF14559.6 KOO22515.1 - 0.63 10.6 8.4 0.25 11.9 0.9 3.2 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO22515.1 - 3.5 7.8 16.3 0.34 11.1 4.8 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat ORC6 PF05460.13 KOO22516.1 - 0.91 8.7 5.5 1.2 8.3 5.5 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) TPR_1 PF00515.28 KOO22517.1 - 1.4e-09 37.3 3.4 0.011 15.6 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO22517.1 - 1.3e-07 31.7 4.2 1.3e-07 31.7 4.2 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO22517.1 - 2.3e-07 31.4 2.1 2.3e-07 31.4 2.1 5.3 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO22517.1 - 3.1e-07 30.0 14.5 0.0032 17.5 0.2 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat Aha1_N PF09229.11 KOO22517.1 - 4.4e-07 30.2 0.0 1.2e-06 28.8 0.0 1.8 1 1 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal TPR_19 PF14559.6 KOO22517.1 - 0.0019 18.7 2.2 0.0019 18.7 2.2 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO22517.1 - 0.0023 17.5 2.7 2.6 7.8 0.0 3.5 3 0 0 3 3 3 1 TPR repeat TPR_8 PF13181.6 KOO22517.1 - 0.033 14.4 10.9 0.52 10.7 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22517.1 - 0.041 14.7 0.5 0.041 14.7 0.5 7.2 5 2 2 7 7 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO22517.1 - 3.3 7.9 6.4 7.2 6.8 0.1 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Ion_trans PF00520.31 KOO22518.1 - 4.6e-16 58.8 1.1 7e-16 58.2 1.1 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO22518.1 - 3.7e-06 26.8 4.6 3.7e-06 26.8 4.6 2.4 3 0 0 3 3 3 1 Ion channel TTL PF03133.15 KOO22520.1 - 2.7e-07 30.0 0.0 3.1e-07 29.8 0.0 1.0 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family N2227 PF07942.12 KOO22521.1 - 4.5e-53 180.2 0.0 6e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein NNMT_PNMT_TEMT PF01234.17 KOO22521.1 - 0.0066 15.7 0.0 0.0099 15.1 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_11 PF08241.12 KOO22521.1 - 0.024 15.3 0.1 0.23 12.1 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22521.1 - 0.075 13.7 0.8 0.32 11.7 0.1 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22522.1 - 1.1e-05 26.1 0.1 2.7e-05 24.8 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO22522.1 - 0.00012 21.6 0.0 0.00019 20.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 KOO22522.1 - 0.0012 18.8 0.0 0.0019 18.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO22522.1 - 0.0018 19.0 0.0 0.0033 18.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO22522.1 - 0.0023 17.8 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO22522.1 - 0.003 17.1 0.0 0.0053 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 KOO22522.1 - 0.0065 15.8 0.0 0.0098 15.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 KOO22522.1 - 0.0095 16.9 0.5 0.053 14.6 0.0 2.4 3 1 0 3 3 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO22522.1 - 0.019 15.6 0.2 0.056 14.1 0.1 2.0 2 1 0 2 2 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 KOO22522.1 - 0.02 14.7 0.0 0.041 13.6 0.0 1.5 2 0 0 2 2 2 0 Lysine methyltransferase Methyltransf_23 PF13489.6 KOO22522.1 - 0.18 11.6 0.0 0.3 10.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain RabGAP-TBC PF00566.18 KOO22524.1 - 1.5e-13 51.0 0.0 1.7e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain FliG_N PF14842.6 KOO22525.1 - 0.098 13.2 0.3 0.52 10.9 0.1 2.2 2 1 0 2 2 2 0 FliG N-terminal domain RR_TM4-6 PF06459.12 KOO22527.1 - 0.85 9.4 13.3 1.2 8.9 13.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_S30 PF01577.16 KOO22527.1 - 1.7 8.2 15.3 2 7.9 15.3 1.0 1 0 0 1 1 1 0 Potyvirus P1 protease DUF4407 PF14362.6 KOO22527.1 - 3.8 6.8 16.3 5.4 6.3 16.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BAF1_ABF1 PF04684.13 KOO22527.1 - 6.1 5.8 13.6 7.1 5.6 13.6 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor mTERF PF02536.14 KOO22528.1 - 1.3e-12 47.3 0.2 5.3e-06 25.6 0.0 3.7 1 1 2 3 3 3 3 mTERF cNMP_binding PF00027.29 KOO22529.1 - 7.9e-10 38.7 0.0 1.1e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Swi5 PF07061.11 KOO22530.1 - 0.00059 19.9 0.3 0.00059 19.9 0.3 2.3 1 1 1 2 2 2 1 Swi5 TBPIP PF07106.13 KOO22530.1 - 0.01 15.7 0.0 0.029 14.3 0.0 1.8 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain Mod_r PF07200.13 KOO22530.1 - 0.023 14.8 2.3 0.036 14.2 2.3 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein HTH_IclR PF09339.10 KOO22530.1 - 0.24 11.3 3.7 1.7 8.5 0.0 3.2 3 0 0 3 3 3 0 IclR helix-turn-helix domain MarR_2 PF12802.7 KOO22530.1 - 0.42 10.5 2.9 0.52 10.2 0.0 2.5 3 0 0 3 3 3 0 MarR family MORN PF02493.20 KOO22531.1 - 0.00022 20.9 4.5 0.006 16.4 0.7 3.1 3 0 0 3 3 3 2 MORN repeat DUF922 PF06037.11 KOO22531.1 - 0.014 15.2 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Kinesin PF00225.23 KOO22532.1 - 1.1e-100 336.8 0.0 1.6e-100 336.3 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain CRAL_TRIO PF00650.20 KOO22532.1 - 1.2e-29 103.1 0.0 2.3e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain Microtub_bd PF16796.5 KOO22532.1 - 1.4e-24 86.7 0.0 2.6e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding CRAL_TRIO_N PF03765.15 KOO22532.1 - 0.0034 17.5 0.0 0.012 15.8 0.0 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain AKNA PF12443.8 KOO22532.1 - 0.058 14.0 0.6 0.21 12.3 0.6 1.9 1 0 0 1 1 1 0 AT-hook-containing transcription factor PIF1 PF05970.14 KOO22532.1 - 0.17 11.0 0.2 0.35 10.0 0.2 1.4 1 0 0 1 1 1 0 PIF1-like helicase zf-CCHC PF00098.23 KOO22533.1 - 0.00016 21.6 3.2 0.00016 21.6 3.2 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 KOO22533.1 - 0.00022 21.1 0.8 0.00022 21.1 0.8 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.6 KOO22533.1 - 0.0006 19.5 2.6 0.0018 18.0 2.6 1.8 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger RPAP2_Rtr1 PF04181.13 KOO22534.1 - 1.9e-20 72.9 0.0 3.4e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family Ank_2 PF12796.7 KOO22535.1 - 1.1e-121 397.6 60.6 3.2e-16 59.7 1.2 10.9 1 1 10 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO22535.1 - 1.3e-105 344.5 16.3 6.1e-11 42.6 0.1 13.5 5 3 9 15 15 15 15 Ankyrin repeats (many copies) Ank PF00023.30 KOO22535.1 - 4.3e-101 327.3 62.6 1.8e-05 25.0 0.0 21.1 21 0 0 21 21 21 20 Ankyrin repeat Ank_5 PF13857.6 KOO22535.1 - 8.6e-95 309.6 37.6 2.4e-09 37.3 0.1 19.2 2 2 18 20 20 20 20 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22535.1 - 7.6e-90 284.0 18.8 0.0025 18.2 0.0 21.1 21 0 0 21 21 21 19 Ankyrin repeat FAD_binding_5 PF00941.21 KOO22535.1 - 1.9e-13 50.5 39.0 0.95 9.2 0.0 16.9 1 1 13 14 14 14 3 FAD binding domain in molybdopterin dehydrogenase UBA PF00627.31 KOO22535.1 - 0.019 14.9 40.0 43 4.1 0.1 14.4 15 0 0 15 15 15 0 UBA/TS-N domain Ribosomal_S11 PF00411.19 KOO22535.1 - 3.3 8.2 72.4 1.9 8.9 5.2 11.6 1 1 12 13 13 13 0 Ribosomal protein S11 p25-alpha PF05517.12 KOO22536.1 - 0.00057 20.1 0.0 1.7 8.8 0.0 4.1 5 0 0 5 5 5 2 p25-alpha EF-hand_1 PF00036.32 KOO22536.1 - 0.67 9.6 4.0 13 5.6 0.0 4.3 4 0 0 4 4 4 0 EF hand zf-MYST PF17772.1 KOO22537.1 - 0.13 11.9 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 MYST family zinc finger domain EF-hand_6 PF13405.6 KOO22538.1 - 2e-12 46.0 0.0 5.7e-05 22.7 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO22538.1 - 2.6e-12 45.4 0.0 4.6e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO22538.1 - 3.4e-11 42.1 0.1 1.4e-05 24.3 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO22538.1 - 1.3e-09 37.7 0.1 2.5e-05 24.0 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO22538.1 - 5.3e-09 36.4 0.0 9.7e-09 35.6 0.0 1.4 1 1 0 1 1 1 1 EF-hand domain pair Peptidase_M50B PF13398.6 KOO22539.1 - 0.06 13.0 0.6 0.084 12.5 0.6 1.2 1 0 0 1 1 1 0 Peptidase M50B-like ANAPC4_WD40 PF12894.7 KOO22540.1 - 2e-21 76.1 0.0 4.6e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain ANAPC4 PF12896.7 KOO22540.1 - 4.2e-14 52.5 0.2 6e-14 52.0 0.2 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 WD40 PF00400.32 KOO22540.1 - 3.6e-05 24.4 2.8 0.00038 21.2 0.2 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat TPR_MLP1_2 PF07926.12 KOO22540.1 - 0.018 15.1 0.2 0.03 14.4 0.2 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein IKI3 PF04762.12 KOO22540.1 - 0.11 10.5 0.0 0.49 8.3 0.0 1.8 2 0 0 2 2 2 0 IKI3 family TPR_MLP1_2 PF07926.12 KOO22541.1 - 0.01 15.9 0.7 0.019 15.1 0.7 1.4 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein CRAL_TRIO PF00650.20 KOO22543.1 - 1.3e-16 60.7 0.0 1.5e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KOO22543.1 - 5.6e-05 23.3 0.0 6.2e-05 23.2 0.0 1.0 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain UPF0051 PF01458.17 KOO22544.1 - 1.1e-61 208.3 0.1 1.4e-61 208.0 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) LRR_4 PF12799.7 KOO22545.1 - 8.6e-11 41.9 1.8 0.0013 19.1 0.0 3.6 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO22545.1 - 8.8e-11 41.6 0.0 1.7e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 KOO22545.1 - 2.6e-08 33.5 3.8 0.0002 21.0 0.0 2.8 3 0 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 KOO22545.1 - 0.11 12.6 1.4 9.9 6.5 0.0 3.7 4 0 0 4 4 4 0 Leucine Rich repeat Ank_2 PF12796.7 KOO22546.1 - 8.9e-11 42.2 0.1 1.1e-06 29.1 0.3 2.6 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO22546.1 - 3.3e-08 33.6 2.5 0.0022 18.2 0.0 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO22546.1 - 1.6e-06 28.3 8.5 2.5 8.7 0.1 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KOO22546.1 - 2.4e-05 24.8 4.3 0.58 10.8 0.2 4.8 1 1 4 5 5 5 4 Ankyrin repeats (many copies) DHHC PF01529.20 KOO22546.1 - 0.0037 17.4 0.2 0.057 13.5 0.2 2.2 1 1 0 1 1 1 1 DHHC palmitoyltransferase LRR_6 PF13516.6 KOO22547.1 - 2.2e-51 167.6 21.4 3.5e-05 23.5 0.0 10.6 10 0 0 10 10 10 10 Leucine Rich repeat LRR_4 PF12799.7 KOO22547.1 - 7.2e-07 29.4 12.5 0.7 10.4 0.2 6.7 4 3 2 6 6 6 2 Leucine Rich repeats (2 copies) EIF_2_alpha PF07541.12 KOO22547.1 - 0.036 14.2 0.5 2.2 8.4 0.5 3.3 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit SpoU_sub_bind PF08032.12 KOO22547.1 - 0.076 13.3 5.6 14 6.1 0.1 4.7 2 1 1 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding YusW PF14039.6 KOO22547.1 - 0.09 13.3 1.5 19 5.9 0.0 3.5 2 1 0 2 2 2 0 YusW-like protein HOASN PF14515.6 KOO22547.1 - 0.13 12.6 19.0 29 5.2 0.0 7.4 1 1 6 7 7 7 0 Haem-oxygenase-associated N-terminal helices CbiG_N PF11760.8 KOO22547.1 - 0.35 10.9 25.8 13 5.9 0.0 7.9 7 1 2 9 9 9 0 Cobalamin synthesis G N-terminal Arm-DNA-bind_1 PF09003.10 KOO22547.1 - 6.6 7.0 25.3 11 6.3 0.1 7.3 5 2 4 9 9 9 0 Bacteriophage lambda integrase, Arm DNA-binding domain CHB_HEX_C PF03174.13 KOO22547.1 - 8.1 6.5 8.0 34 4.5 0.0 5.0 5 2 1 6 6 6 0 Chitobiase/beta-hexosaminidase C-terminal domain 2-Hacid_dh_C PF02826.19 KOO22549.1 - 6.6e-33 113.6 0.0 1.1e-32 112.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOO22549.1 - 7.3e-18 64.5 0.0 1.3e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOO22549.1 - 0.00035 20.8 0.0 0.001 19.2 0.0 1.9 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.25 KOO22549.1 - 0.00041 20.0 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 ACT domain DUF1350 PF07082.11 KOO22549.1 - 0.045 13.0 0.0 0.11 11.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1350) GFO_IDH_MocA PF01408.22 KOO22549.1 - 0.12 13.2 0.1 0.35 11.7 0.0 1.9 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold K_channel_TID PF07941.11 KOO22549.1 - 0.93 10.0 9.5 2.1 8.9 9.5 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain SNF2_N PF00176.23 KOO22550.1 - 2.2e-40 138.5 0.0 6.8e-40 136.8 0.0 1.7 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO22550.1 - 2.3e-15 56.9 0.0 7.6e-15 55.2 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO22550.1 - 1.8e-06 28.1 0.0 4.1e-06 26.9 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3138 PF11336.8 KOO22550.1 - 0.016 13.9 1.8 0.1 11.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) p25-alpha PF05517.12 KOO22551.1 - 2.2e-05 24.7 0.0 3.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 p25-alpha DUF3016 PF11454.8 KOO22552.1 - 0.19 11.5 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3016) DUF2109 PF09882.9 KOO22552.1 - 3.4 7.7 11.4 1.7 8.7 7.3 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2109) TerC PF03741.16 KOO22555.1 - 1.5e-49 168.1 7.5 2.6e-49 167.4 7.5 1.4 1 0 0 1 1 1 1 Integral membrane protein TerC family Metallophos PF00149.28 KOO22556.1 - 1.4e-18 68.1 0.0 2.3e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO22556.1 - 0.0011 19.2 0.0 0.0027 17.9 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PIG-S PF10510.9 KOO22556.1 - 0.021 13.7 0.1 0.038 12.8 0.1 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein rve_3 PF13683.6 KOO22556.1 - 0.068 13.0 0.2 5.8 6.8 0.0 3.4 3 0 0 3 3 3 0 Integrase core domain EF-hand_1 PF00036.32 KOO22557.1 - 0.049 13.2 0.2 0.14 11.8 0.2 1.8 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 KOO22557.1 - 0.18 11.8 0.1 0.49 10.5 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain Ank_5 PF13857.6 KOO22558.1 - 6.6e-23 80.5 3.0 5.4e-10 39.3 0.5 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO22558.1 - 1.9e-19 70.0 5.1 6.2e-12 45.9 0.7 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO22558.1 - 2.1e-17 63.2 0.5 6e-09 36.3 0.2 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) TPR_2 PF07719.17 KOO22558.1 - 6.8e-15 53.9 4.0 0.00031 20.6 0.6 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat Ank PF00023.30 KOO22558.1 - 2.4e-14 53.0 2.3 2.8e-05 24.3 0.2 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 KOO22558.1 - 1.7e-13 49.4 0.0 0.0077 16.7 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat TPR_1 PF00515.28 KOO22558.1 - 3.9e-12 45.4 2.6 2.4e-05 24.0 0.9 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO22558.1 - 8.1e-10 38.2 4.1 0.00068 19.3 0.1 3.0 1 1 2 3 3 3 2 TPR repeat TPR_8 PF13181.6 KOO22558.1 - 1.4e-08 34.2 2.5 0.1 12.9 0.8 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO22558.1 - 7.9e-07 29.6 3.5 8.6e-05 23.1 0.2 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22558.1 - 1.5e-06 28.6 5.9 0.018 15.8 0.2 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO22558.1 - 4.2e-06 27.2 1.9 0.071 13.6 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO22558.1 - 0.0012 19.0 1.2 2.3 8.8 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO22558.1 - 0.0071 16.4 0.1 0.49 10.5 0.0 3.2 4 0 0 4 4 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 KOO22558.1 - 0.0085 16.4 1.4 0.46 10.8 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat DEC-1_N PF04625.13 KOO22558.1 - 0.012 14.6 7.7 0.018 14.1 7.7 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region TPR_10 PF13374.6 KOO22558.1 - 0.074 13.0 1.5 15 5.6 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat SAP PF02037.27 KOO22558.1 - 0.18 11.6 0.5 0.44 10.3 0.5 1.7 1 0 0 1 1 1 0 SAP domain Pro_isomerase PF00160.21 KOO22559.1 - 5e-23 82.1 0.0 9e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ELO PF01151.18 KOO22560.1 - 1.9e-47 161.9 9.3 2.3e-47 161.6 9.3 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Ank_2 PF12796.7 KOO22561.1 - 1e-49 167.0 25.7 1e-12 48.4 1.0 6.3 3 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO22561.1 - 8.4e-46 153.8 2.9 1.2e-08 35.3 0.0 8.2 4 3 4 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22561.1 - 1.5e-38 126.4 10.2 0.00079 19.7 0.0 11.4 11 0 0 11 11 11 8 Ankyrin repeat Ank PF00023.30 KOO22561.1 - 6e-35 118.2 17.5 4.5e-05 23.7 0.0 10.2 10 0 0 10 10 10 9 Ankyrin repeat Ank_5 PF13857.6 KOO22561.1 - 2.6e-29 100.9 12.3 1.1e-08 35.1 0.0 7.7 5 2 4 9 9 9 8 Ankyrin repeats (many copies) Med13_C PF06333.12 KOO22561.1 - 0.1 11.8 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain BLOC1_2 PF10046.9 KOO22562.1 - 0.074 13.4 1.3 0.98 9.8 0.1 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.11 KOO22562.1 - 0.084 13.1 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Syntaxin-6_N PF09177.11 KOO22562.1 - 0.23 12.0 3.9 1.1 9.9 3.9 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal VPS38 PF17649.1 KOO22563.1 - 0.069 12.0 2.9 0.09 11.6 2.9 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting 38 DUF4407 PF14362.6 KOO22563.1 - 0.083 12.2 20.6 0.011 15.1 7.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Csm1_N PF18504.1 KOO22563.1 - 0.11 12.8 7.4 0.28 11.5 2.9 2.7 2 0 0 2 2 2 0 Csm1 N-terminal domain GHL13 PF14883.6 KOO22563.1 - 0.28 10.2 6.8 0.015 14.4 1.6 1.4 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase family 13 ERM PF00769.19 KOO22563.1 - 0.29 10.9 25.8 0.031 14.1 8.7 2.2 2 1 0 2 2 2 0 Ezrin/radixin/moesin family ADIP PF11559.8 KOO22563.1 - 3.2 7.8 16.1 8.2 6.5 8.7 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding EMP24_GP25L PF01105.24 KOO22564.1 - 8e-23 81.3 0.8 8.9e-23 81.2 0.8 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD CopD PF05425.13 KOO22564.1 - 0.072 13.5 0.3 0.11 12.9 0.3 1.3 1 0 0 1 1 1 0 Copper resistance protein D Ribosomal_L27A PF00828.19 KOO22565.1 - 2.8e-15 57.1 0.0 3e-15 57.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A IQ PF00612.27 KOO22566.1 - 0.23 11.3 21.3 0.14 12.0 0.4 4.2 4 0 0 4 4 4 0 IQ calmodulin-binding motif Pept_tRNA_hydro PF01195.19 KOO22567.1 - 1.7e-25 89.9 0.0 1.9e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Myb_DNA-binding PF00249.31 KOO22568.1 - 4.3e-25 87.6 2.4 5.3e-12 45.7 0.2 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO22568.1 - 5.5e-15 55.4 0.1 3.3e-06 27.2 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO22568.1 - 1.8e-06 27.8 0.0 0.027 14.3 0.0 2.3 2 0 0 2 2 2 2 Myb DNA-binding like SLIDE PF09111.10 KOO22568.1 - 0.033 14.2 0.0 0.25 11.4 0.0 2.2 2 1 0 2 2 2 0 SLIDE BTG PF07742.12 KOO22569.1 - 1.3e-16 60.4 0.0 2.3e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 BTG family WD40 PF00400.32 KOO22570.1 - 2.4e-07 31.3 0.9 0.34 11.9 0.1 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat SsgA PF04686.12 KOO22570.1 - 0.024 14.6 0.1 13 5.9 0.0 3.2 3 0 0 3 3 3 0 Streptomyces sporulation and cell division protein, SsgA FPL PF09758.9 KOO22571.1 - 9.7e-52 174.9 0.1 1.5e-51 174.3 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein CRAL_TRIO PF00650.20 KOO22571.1 - 2.1e-07 30.8 0.0 4.6e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain RAI16-like PF10257.9 KOO22571.1 - 7.6e-06 25.0 1.7 8.9e-06 24.8 0.2 1.9 2 0 0 2 2 2 1 Retinoic acid induced 16-like protein GBP PF02263.19 KOO22572.1 - 1.5e-61 208.0 0.0 2.1e-61 207.5 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 KOO22572.1 - 1.3e-16 60.9 0.0 1.3e-16 60.9 0.0 3.7 2 1 2 4 4 4 1 Guanylate-binding protein, C-terminal domain FAM184 PF15665.5 KOO22572.1 - 6.3 6.5 30.7 14 5.3 30.7 1.6 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B LRR_6 PF13516.6 KOO22573.1 - 4.5e-14 51.2 6.7 0.022 14.8 0.1 5.9 6 0 0 6 6 6 4 Leucine Rich repeat SAP PF02037.27 KOO22573.1 - 7.9e-06 25.5 0.1 2.3e-05 24.0 0.1 1.9 1 0 0 1 1 1 1 SAP domain SpoU_sub_bind PF08032.12 KOO22573.1 - 0.06 13.6 2.1 2.6 8.4 0.1 3.7 2 1 2 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding HOASN PF14515.6 KOO22573.1 - 0.069 13.5 7.8 4.3 7.8 0.2 4.4 2 1 2 4 4 4 0 Haem-oxygenase-associated N-terminal helices LRR_4 PF12799.7 KOO22573.1 - 0.13 12.7 3.1 10 6.7 0.0 4.1 2 1 3 5 5 5 0 Leucine Rich repeats (2 copies) LAGLIDADG_2 PF03161.13 KOO22575.1 - 0.1 12.6 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 LAGLIDADG DNA endonuclease family DUF2834 PF11196.8 KOO22576.1 - 2.9 8.3 5.9 1.4 9.3 0.2 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2834) TPR_MLP1_2 PF07926.12 KOO22577.1 - 0.0081 16.2 10.0 0.0081 16.2 10.0 2.8 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 KOO22577.1 - 0.02 15.4 11.9 0.02 15.4 11.9 2.9 2 1 0 2 2 2 0 Apg6 coiled-coil region Tropomyosin PF00261.20 KOO22577.1 - 0.27 10.6 33.0 0.13 11.6 9.0 3.1 2 1 0 2 2 2 0 Tropomyosin DUF2721 PF11026.8 KOO22577.1 - 1.6 8.7 4.3 0.65 9.9 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) ATG16 PF08614.11 KOO22577.1 - 3.5 7.8 34.5 0.61 10.3 11.0 2.9 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) KELK PF15796.5 KOO22577.1 - 7.3 7.1 28.5 0.29 11.6 4.9 4.0 1 1 3 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Thioredoxin PF00085.20 KOO22578.1 - 3.8e-11 42.9 0.0 4.6e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 KOO22578.1 - 0.018 14.0 0.0 0.021 13.8 0.0 1.1 1 0 0 1 1 1 0 Phosducin DUF2997 PF11211.8 KOO22578.1 - 0.088 12.6 0.2 0.19 11.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) Cwf_Cwc_15 PF04889.12 KOO22579.1 - 4.9 6.8 7.7 6.6 6.4 7.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Fasciclin PF02469.22 KOO22580.1 - 2.5e-35 121.5 0.0 5.6e-35 120.4 0.0 1.6 1 0 0 1 1 1 1 Fasciclin domain Cytadhesin_P30 PF07271.11 KOO22581.1 - 0.0087 15.7 0.3 0.016 14.8 0.3 1.5 1 0 0 1 1 1 1 Cytadhesin P30/P32 DDRGK PF09756.9 KOO22581.1 - 0.043 13.4 10.7 0.07 12.7 10.7 1.3 1 0 0 1 1 1 0 DDRGK domain SAGA-Tad1 PF12767.7 KOO22581.1 - 0.074 12.8 1.2 0.1 12.4 1.1 1.3 1 1 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF4778 PF16008.5 KOO22581.1 - 0.2 11.7 1.5 0.24 11.4 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) F420H2_quin_red PF04075.14 KOO22581.1 - 1.3 9.2 7.8 18 5.5 5.1 3.1 2 1 0 2 2 2 0 F420H(2)-dependent quinone reductase DUF4407 PF14362.6 KOO22581.1 - 3 7.1 11.1 4.2 6.6 11.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hema_stalk PF08720.10 KOO22582.1 - 0.14 11.9 0.0 0.36 10.5 0.0 1.7 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk NPV_P10 PF05531.12 KOO22582.1 - 0.45 11.0 25.0 4.4 7.8 0.7 6.0 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein ART PF01129.18 KOO22583.1 - 1.5e-05 24.4 0.0 2.4e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO22583.1 - 0.0028 17.0 0.0 0.0096 15.3 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme CrgA PF06781.12 KOO22583.1 - 0.12 12.4 0.9 14 5.8 0.4 2.7 2 0 0 2 2 2 0 Cell division protein CrgA NDK PF00334.19 KOO22584.1 - 2.6e-53 179.7 0.0 3.2e-53 179.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Pkinase PF00069.25 KOO22585.1 - 0.059 12.7 0.2 2.1 7.6 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain TFIIS_C PF01096.18 KOO22586.1 - 1.8e-22 78.9 5.0 1.8e-22 78.9 5.0 2.4 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 KOO22586.1 - 7.5e-07 28.9 1.4 7.5e-07 28.9 1.4 3.0 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 KOO22586.1 - 6.8e-06 26.0 7.8 0.00081 19.3 1.9 2.3 2 0 0 2 2 2 2 Transposase zinc-ribbon domain C1_1 PF00130.22 KOO22586.1 - 0.00012 21.9 5.9 0.00083 19.2 0.4 2.5 2 1 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Nudix_N_2 PF14803.6 KOO22586.1 - 0.0015 18.4 7.4 0.014 15.3 0.7 3.2 3 0 0 3 3 3 1 Nudix N-terminal zf-RRPl_C4 PF17026.5 KOO22586.1 - 0.0047 17.0 1.4 0.0065 16.6 1.4 1.3 1 0 0 1 1 1 1 Putative ribonucleoprotein zinc-finger pf C4 type DpnI PF06044.12 KOO22586.1 - 0.018 14.7 5.7 0.055 13.1 0.1 2.1 1 1 0 2 2 2 0 Dam-replacing family DZR PF12773.7 KOO22586.1 - 0.032 14.3 9.5 1.4 9.0 3.8 2.5 2 2 0 2 2 2 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 KOO22586.1 - 0.036 14.2 6.7 1.9 8.7 0.8 3.4 3 0 0 3 3 3 0 Zinc ribbon domain PHD PF00628.29 KOO22586.1 - 0.072 13.0 6.1 0.81 9.6 2.5 2.9 2 1 0 2 2 2 0 PHD-finger Zn_ribbon_recom PF13408.6 KOO22586.1 - 0.074 13.6 4.4 1.1 9.9 0.1 3.0 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain DUF3797 PF12677.7 KOO22586.1 - 0.085 12.8 1.0 0.085 12.8 1.0 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF3797) zf-ZPR1 PF03367.13 KOO22586.1 - 0.16 11.9 2.0 0.18 11.6 0.5 1.7 2 0 0 2 2 2 0 ZPR1 zinc-finger domain zinc_ribbon_4 PF13717.6 KOO22586.1 - 0.18 11.7 8.6 0.86 9.6 0.4 3.2 3 0 0 3 3 3 0 zinc-ribbon domain Desulfoferrod_N PF06397.12 KOO22586.1 - 0.49 10.1 5.6 3.2 7.4 0.1 2.7 2 1 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain zf-H2C2_2 PF13465.6 KOO22586.1 - 2 9.0 7.6 38 4.9 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger double domain CpXC PF14353.6 KOO22586.1 - 3.1 7.9 6.4 5.6 7.0 3.8 2.5 2 1 1 3 3 2 0 CpXC protein DUF4379 PF14311.6 KOO22586.1 - 4.4 7.7 9.0 2 8.8 1.4 2.9 2 1 0 3 3 3 0 Probable Zinc-ribbon domain TF_Zn_Ribbon PF08271.12 KOO22586.1 - 5.2 6.7 10.6 0.13 11.8 1.3 2.7 2 2 0 2 2 2 0 TFIIB zinc-binding zf-Mss51 PF13824.6 KOO22586.1 - 5.3 7.2 9.3 15 5.8 0.3 2.8 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C3HC4_4 PF15227.6 KOO22586.1 - 5.8 7.2 9.4 32 4.8 0.3 3.3 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING C1_2 PF03107.16 KOO22586.1 - 5.9 7.3 14.1 0.7 10.3 1.4 2.9 2 1 0 2 2 2 0 C1 domain zinc_ribbon_13 PF09855.9 KOO22586.1 - 6.3 7.0 7.3 29 4.9 2.7 3.1 2 1 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-HIT PF04438.16 KOO22586.1 - 7.6 6.5 14.7 8.2 6.4 0.3 3.9 4 0 0 4 4 4 0 HIT zinc finger OrfB_Zn_ribbon PF07282.11 KOO22586.1 - 9 6.3 9.4 32 4.6 4.0 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain SH2_2 PF14633.6 KOO22587.1 - 1.6e-43 148.6 0.0 1.6e-43 148.6 0.0 1.8 2 0 0 2 2 2 1 SH2 domain HHH_7 PF14635.6 KOO22587.1 - 4.1e-15 56.0 0.0 8.7e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_9 PF17674.1 KOO22587.1 - 1.5e-07 32.2 0.4 0.0051 17.7 0.1 3.6 1 1 1 2 2 2 2 HHH domain SPT6_acidic PF14632.6 KOO22587.1 - 5.6e-05 23.6 2.5 5.6e-05 23.6 2.5 6.0 5 1 1 6 6 6 2 Acidic N-terminal SPT6 Tex_YqgF PF16921.5 KOO22587.1 - 0.00049 20.6 0.0 0.011 16.2 0.0 2.6 2 0 0 2 2 2 1 Tex protein YqgF-like domain HHH_3 PF12836.7 KOO22587.1 - 0.023 15.0 0.0 0.081 13.2 0.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix motif YqgF PF14639.6 KOO22587.1 - 0.054 13.3 0.1 0.28 10.9 0.0 2.3 1 1 1 2 2 2 0 Holliday-junction resolvase-like of SPT6 Trp_Tyr_perm PF03222.13 KOO22588.1 - 1.3e-13 50.8 15.8 3.5e-13 49.4 15.8 1.6 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family PHY PF00360.20 KOO22588.1 - 0.13 11.5 0.1 0.23 10.8 0.1 1.3 1 0 0 1 1 1 0 Phytochrome region ArgJ PF01960.18 KOO22589.1 - 2.6e-111 372.0 0.0 3.2e-111 371.7 0.0 1.0 1 0 0 1 1 1 1 ArgJ family TIG PF01833.24 KOO22590.1 - 7.6e-08 32.3 0.2 1.3e-07 31.6 0.2 1.4 1 0 0 1 1 1 1 IPT/TIG domain Ank_5 PF13857.6 KOO22590.1 - 0.0006 20.0 0.0 0.0012 19.0 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO22590.1 - 0.0067 17.0 0.0 0.013 16.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO22590.1 - 0.015 15.8 0.0 0.038 14.6 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22590.1 - 0.018 15.5 0.1 0.055 14.0 0.1 1.8 1 0 0 1 1 1 0 Ankyrin repeat Ank PF00023.30 KOO22590.1 - 0.098 13.1 0.2 0.36 11.3 0.2 2.0 1 0 0 1 1 1 0 Ankyrin repeat PBD PF00786.28 KOO22591.1 - 0.1 13.0 0.4 1 9.8 0.0 2.7 3 0 0 3 3 3 0 P21-Rho-binding domain DASH_Dad2 PF08654.10 KOO22591.1 - 0.13 12.7 1.0 8.2 6.9 0.6 2.7 3 0 0 3 3 3 0 DASH complex subunit Dad2 CBFD_NFYB_HMF PF00808.23 KOO22593.1 - 4.8e-12 46.0 0.0 7.2e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOO22593.1 - 0.00035 20.9 0.0 0.00043 20.7 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 MauE PF07291.11 KOO22593.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Methylamine utilisation protein MauE Kinesin PF00225.23 KOO22594.1 - 2.2e-118 395.0 0.0 2.2e-118 395.0 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOO22594.1 - 9e-27 93.8 2.9 2.6e-26 92.4 0.0 2.7 2 1 0 2 2 2 1 Microtubule binding Acyl-CoA_ox_N PF14749.6 KOO22594.1 - 5.2 7.7 14.8 0.27 11.8 6.0 2.7 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Kinesin_assoc PF16183.5 KOO22594.1 - 6.5 6.9 20.0 0.75 9.9 12.0 3.1 1 1 2 3 3 3 0 Kinesin-associated Corona_S2 PF01601.16 KOO22594.1 - 8.3 4.8 6.9 0.47 8.9 0.5 1.9 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein CTP_transf_3 PF02348.19 KOO22596.1 - 3.2e-45 154.7 0.0 4.1e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 KOO22596.1 - 3.7e-11 43.7 2.1 3.7e-11 43.7 2.1 2.5 1 1 1 2 2 2 1 MobA-like NTP transferase domain IspD PF01128.19 KOO22596.1 - 1.6e-05 24.8 0.8 2.8e-05 24.0 0.8 1.4 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Arabinose_Iso_C PF11762.8 KOO22596.1 - 0.031 14.1 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 L-arabinose isomerase C-terminal domain QRPTase_C PF01729.19 KOO22596.1 - 0.049 13.4 0.6 0.17 11.7 0.2 1.8 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Methyltransf_11 PF08241.12 KOO22597.1 - 2.3e-09 37.8 0.0 4.1e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22597.1 - 2.9e-06 27.9 0.0 0.00013 22.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO22597.1 - 0.0011 18.4 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 KOO22597.1 - 0.0068 16.3 0.0 0.74 9.6 0.0 2.1 2 0 0 2 2 2 2 Hypothetical methyltransferase Methyltransf_31 PF13847.6 KOO22597.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22599.1 - 6.6e-06 26.8 0.0 1.6e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.17 KOO22599.1 - 2.6e-05 23.7 0.0 2.9e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_30 PF05430.11 KOO22599.1 - 3.7e-05 23.6 0.0 6.8e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_11 PF08241.12 KOO22599.1 - 5e-05 23.9 0.0 9.8e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO22599.1 - 6.2e-05 22.6 0.0 0.00017 21.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 KOO22599.1 - 0.0041 17.0 0.0 0.024 14.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 KOO22599.1 - 0.02 15.9 0.0 0.038 15.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 KOO22599.1 - 0.24 11.1 0.0 0.37 10.5 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein NHL PF01436.21 KOO22600.1 - 2e-09 37.0 0.1 6.2e-06 26.0 0.0 3.5 3 0 0 3 3 3 2 NHL repeat TolB_like PF15869.5 KOO22600.1 - 0.0094 15.2 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 TolB-like 6-blade propeller-like DUF5128 PF17170.4 KOO22600.1 - 0.026 13.7 0.1 0.04 13.1 0.1 1.2 1 0 0 1 1 1 0 6-bladed beta-propeller PreAtp-grasp PF18604.1 KOO22601.1 - 0.074 12.7 0.0 0.54 9.9 0.0 2.4 2 1 0 2 2 2 0 Pre ATP-grasp domain PWWP PF00855.17 KOO22602.1 - 4.9e-12 46.1 0.0 4.9e-12 46.1 0.0 2.8 2 1 0 2 2 2 1 PWWP domain HMG_box PF00505.19 KOO22602.1 - 5.6e-11 42.7 0.8 5.6e-11 42.7 0.8 2.9 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO22602.1 - 9.2e-05 23.0 1.4 9.2e-05 23.0 1.4 2.9 2 2 1 3 3 3 1 HMG-box domain BAF1_ABF1 PF04684.13 KOO22602.1 - 0.08 12.0 6.4 0.097 11.7 6.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RNA_polI_A34 PF08208.11 KOO22602.1 - 2 8.5 19.8 0.42 10.7 4.7 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 TauD PF02668.16 KOO22603.1 - 7.2e-30 104.7 0.0 1.3e-29 103.8 0.0 1.4 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Pro-kuma_activ PF09286.11 KOO22605.1 - 1.9e-29 102.8 0.0 3.3e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 KOO22605.1 - 8e-06 25.3 0.4 1.3e-05 24.7 0.4 1.2 1 0 0 1 1 1 1 Subtilase family ABC_tran PF00005.27 KOO22606.1 - 2.1e-29 102.8 0.0 5.4e-14 52.9 0.0 2.6 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO22606.1 - 1.1e-21 77.9 6.8 1.2e-07 31.9 0.4 4.2 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO22606.1 - 8.3e-09 35.2 3.1 0.0069 15.8 0.4 3.9 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOO22606.1 - 9.2e-07 28.5 0.1 0.024 14.4 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 KOO22606.1 - 6.6e-06 25.8 2.7 0.018 14.6 0.1 3.3 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 KOO22606.1 - 6.7e-06 26.7 0.5 0.085 13.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 KOO22606.1 - 2.6e-05 24.7 0.2 0.75 10.2 0.0 3.4 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 KOO22606.1 - 3.2e-05 23.7 0.1 0.29 10.9 0.0 2.8 3 0 0 3 3 2 2 Ethanolamine utilisation - propanediol utilisation DUF3584 PF12128.8 KOO22606.1 - 5.2e-05 21.0 2.7 0.022 12.3 0.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3584) AAA_24 PF13479.6 KOO22606.1 - 7.3e-05 22.6 0.1 0.23 11.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 KOO22606.1 - 0.0001 22.1 0.8 0.15 11.7 0.0 3.0 3 1 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 KOO22606.1 - 0.00011 22.1 0.1 0.22 11.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 KOO22606.1 - 0.00013 21.5 0.1 0.09 12.2 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_28 PF13521.6 KOO22606.1 - 0.00031 21.0 2.3 0.38 11.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain Zeta_toxin PF06414.12 KOO22606.1 - 0.00036 19.9 0.2 0.7 9.1 0.1 2.2 2 0 0 2 2 2 2 Zeta toxin IstB_IS21 PF01695.17 KOO22606.1 - 0.00037 20.3 7.4 1.8 8.3 0.3 4.3 3 1 0 4 4 4 1 IstB-like ATP binding protein AAA_33 PF13671.6 KOO22606.1 - 0.00051 20.2 0.3 1.1 9.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 KOO22606.1 - 0.00058 19.7 0.9 0.95 9.1 0.0 3.1 4 0 0 4 4 4 1 AAA ATPase domain SRP54 PF00448.22 KOO22606.1 - 0.00079 19.1 2.0 0.48 10.0 0.1 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_14 PF13173.6 KOO22606.1 - 0.0022 18.0 0.2 5 7.2 0.0 3.3 4 0 0 4 4 4 0 AAA domain MMR_HSR1 PF01926.23 KOO22606.1 - 0.0028 17.7 0.3 3.3 7.8 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase DLIC PF05783.11 KOO22606.1 - 0.0029 16.5 0.3 0.58 8.9 0.0 2.3 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) AAA_16 PF13191.6 KOO22606.1 - 0.0037 17.6 7.0 0.56 10.6 2.1 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_13 PF13166.6 KOO22606.1 - 0.004 15.9 0.1 1.7 7.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain Roc PF08477.13 KOO22606.1 - 0.0049 17.1 0.1 3.9 7.7 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 KOO22606.1 - 0.005 16.8 2.7 9 6.3 0.0 4.0 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 KOO22606.1 - 0.0052 16.8 0.1 1.8 8.6 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 KOO22606.1 - 0.0061 17.1 0.5 1.4 9.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF615 PF04751.14 KOO22606.1 - 0.0061 16.6 0.0 2.1 8.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF615) AAA_22 PF13401.6 KOO22606.1 - 0.012 15.9 10.5 2 8.7 0.0 4.0 3 1 0 3 3 3 0 AAA domain AAA_27 PF13514.6 KOO22606.1 - 0.015 14.9 0.2 2.7 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 KOO22606.1 - 0.017 14.4 0.1 2.4 7.3 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_7 PF12775.7 KOO22606.1 - 0.021 14.4 0.2 6.2 6.3 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 KOO22606.1 - 0.028 14.0 2.6 4.2 6.9 0.5 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain EF-hand_like PF09279.11 KOO22606.1 - 0.031 14.8 0.0 10 6.7 0.0 2.3 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like TniB PF05621.11 KOO22606.1 - 0.044 13.2 3.3 6.5 6.1 0.1 3.7 4 0 0 4 4 4 0 Bacterial TniB protein ATP-synt_ab PF00006.25 KOO22606.1 - 0.12 12.1 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.22 KOO22606.1 - 0.19 12.1 0.2 16 5.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase MukB PF04310.12 KOO22606.1 - 0.2 11.4 0.3 8.4 6.1 0.1 2.2 2 0 0 2 2 2 0 MukB N-terminal RuvB_N PF05496.12 KOO22606.1 - 0.26 11.0 0.6 19 5.0 0.0 2.9 3 0 0 3 3 2 0 Holliday junction DNA helicase RuvB P-loop domain MobB PF03205.14 KOO22606.1 - 0.38 10.6 1.3 31 4.5 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.12 KOO22606.1 - 6.6 6.6 14.2 1.5 8.7 0.4 3.2 4 1 0 4 4 2 0 NACHT domain HMG_box PF00505.19 KOO22608.1 - 2.9e-16 59.6 0.2 2.9e-16 59.6 0.2 2.8 2 1 1 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO22608.1 - 1.4e-10 41.7 0.7 1.4e-10 41.7 0.7 2.5 2 1 1 3 3 3 1 HMG-box domain Myb_DNA-binding PF00249.31 KOO22608.1 - 2.4e-09 37.2 0.0 5.7e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO22608.1 - 5.8e-05 23.3 0.0 0.00015 21.9 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain SpoVR PF04293.13 KOO22608.1 - 1.4 7.5 4.8 2.9 6.5 4.8 1.5 1 0 0 1 1 1 0 SpoVR like protein Ion_trans_2 PF07885.16 KOO22609.1 - 1.3e-28 98.8 15.8 9.8e-16 57.5 7.2 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KOO22609.1 - 3.5e-07 29.7 6.0 0.00056 19.2 0.1 2.3 2 1 0 2 2 2 2 Ion transport protein Lig_chan PF00060.26 KOO22609.1 - 0.015 15.1 0.5 0.18 11.6 0.0 2.0 2 0 0 2 2 2 0 Ligand-gated ion channel DUF1356 PF07092.12 KOO22610.1 - 1.1e-06 28.1 4.0 0.00088 18.6 0.5 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1356) DnaJ_CXXCXGXG PF00684.19 KOO22610.1 - 2.5e-05 24.5 9.0 0.021 15.2 0.3 3.1 2 1 1 3 3 3 2 DnaJ central domain DUF5351 PF17302.2 KOO22610.1 - 0.024 14.8 15.0 1.5 9.0 0.5 4.2 4 0 0 4 4 4 0 Family of unknown function (DUF5351) Anti-TRAP PF15777.5 KOO22610.1 - 0.34 10.9 12.6 5.9 6.9 0.1 3.9 2 2 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein Peptidase_C2 PF00648.21 KOO22612.1 - 3.8e-39 134.5 0.0 2.5e-38 131.8 0.0 2.1 1 1 0 1 1 1 1 Calpain family cysteine protease TPR_1 PF00515.28 KOO22612.1 - 0.077 12.9 0.2 0.2 11.5 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO22612.1 - 0.11 12.5 0.0 0.53 10.4 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO22612.1 - 0.15 12.3 0.0 0.43 10.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.25 KOO22613.1 - 2.7e-38 131.8 0.0 3.7e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22613.1 - 9.9e-38 129.9 0.0 1.4e-37 129.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_8 PF13855.6 KOO22613.1 - 0.0009 19.0 0.1 0.0017 18.1 0.1 1.5 1 0 0 1 1 1 1 Leucine rich repeat APH PF01636.23 KOO22613.1 - 0.025 14.5 0.0 0.094 12.6 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO22613.1 - 0.1 11.5 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Mrr_cat PF04471.12 KOO22614.1 - 2.3e-17 63.1 0.1 3.4e-16 59.3 0.0 2.3 2 0 0 2 2 2 1 Restriction endonuclease Spc7 PF08317.11 KOO22614.1 - 0.29 10.0 16.2 0.045 12.6 8.5 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein IFT57 PF10498.9 KOO22614.1 - 0.36 9.8 2.9 2.7 6.9 2.9 1.9 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 HAUS-augmin3 PF14932.6 KOO22614.1 - 0.58 9.7 10.2 0.55 9.8 8.8 1.6 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 SesA PF17107.5 KOO22614.1 - 1.1 9.5 4.4 2.6 8.2 4.4 1.7 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases MCC-bdg_PDZ PF10506.9 KOO22614.1 - 1.6 8.8 6.2 1.1 9.3 2.5 2.6 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome HemX PF04375.14 KOO22614.1 - 2 7.6 10.3 0.65 9.2 1.6 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase CREPT PF16566.5 KOO22614.1 - 2.2 8.4 7.1 4.6 7.4 7.1 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Apolipo_F PF15148.6 KOO22614.1 - 3 7.3 6.6 0.69 9.4 3.0 1.7 2 0 0 2 2 2 0 Apolipoprotein F DUF3584 PF12128.8 KOO22614.1 - 7.1 4.0 16.5 11 3.4 16.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Zn_ribbon_SprT PF17283.2 KOO22615.1 - 2.8e-07 30.3 4.0 5.9e-07 29.3 4.0 1.5 1 0 0 1 1 1 1 SprT-like zinc ribbon domain SprT-like PF10263.9 KOO22615.1 - 3.5e-07 30.1 0.2 6.5e-07 29.2 0.1 1.5 2 0 0 2 2 2 1 SprT-like family HMG_box PF00505.19 KOO22615.1 - 8.3e-05 22.9 0.0 0.00015 22.1 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box Zn-ribbon_8 PF09723.10 KOO22615.1 - 8.5e-05 22.6 3.5 0.00021 21.3 3.5 1.6 1 0 0 1 1 1 1 Zinc ribbon domain HMG_box_2 PF09011.10 KOO22615.1 - 0.011 16.4 0.0 0.017 15.7 0.0 1.3 1 0 0 1 1 1 0 HMG-box domain DUF2072 PF09845.9 KOO22615.1 - 0.073 13.3 0.2 0.091 13.0 0.2 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein NAD_binding_1 PF00175.21 KOO22616.1 - 5.6e-32 110.6 0.0 8.6e-32 110.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOO22616.1 - 5.5e-26 90.8 0.0 1.5e-23 83.0 0.0 2.4 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_9 PF08021.11 KOO22616.1 - 0.00014 22.0 0.0 0.00023 21.4 0.0 1.3 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain NAD_binding_6 PF08030.12 KOO22616.1 - 0.00027 21.1 0.0 0.017 15.3 0.0 2.3 2 0 0 2 2 2 1 Ferric reductase NAD binding domain PX PF00787.24 KOO22617.1 - 3.1e-14 52.9 0.0 5.1e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 PX domain CUE PF02845.16 KOO22617.1 - 0.0085 15.8 0.7 0.016 14.9 0.1 1.9 2 0 0 2 2 2 1 CUE domain Helicase_C PF00271.31 KOO22618.1 - 2.3e-08 34.4 0.0 5.5e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain INCENP_ARK-bind PF03941.15 KOO22618.1 - 0.034 14.1 0.3 0.034 14.1 0.3 3.0 2 1 1 3 3 3 0 Inner centromere protein, ARK binding region DEAD PF00270.29 KOO22619.1 - 2.5e-22 79.5 0.1 3.6e-22 79.0 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO22619.1 - 1.1e-05 25.6 0.0 0.00017 21.7 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOO22619.1 - 0.052 13.8 0.7 0.65 10.3 0.7 2.3 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KOO22619.1 - 0.12 12.7 0.3 0.22 11.8 0.3 1.7 1 1 0 1 1 1 0 AAA domain EF-hand_1 PF00036.32 KOO22620.1 - 2e-09 36.3 0.2 7.5e-05 22.0 0.1 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO22620.1 - 8.2e-08 32.6 0.4 3.3e-07 30.7 0.3 2.1 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO22620.1 - 5.4e-06 25.7 2.6 0.00081 18.8 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO22620.1 - 1.2e-05 25.1 0.4 0.0001 22.1 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO22620.1 - 1.7e-05 24.4 0.1 0.23 11.5 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain Spc7 PF08317.11 KOO22620.1 - 0.0013 17.7 0.2 0.0019 17.2 0.2 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Peptidase_C1 PF00112.23 KOO22621.1 - 8.7e-50 169.8 8.0 1.8e-49 168.8 8.0 1.5 1 1 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KOO22621.1 - 3.7e-07 30.5 1.0 5.8e-07 29.9 1.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KOO22621.1 - 0.0064 15.3 1.2 0.52 9.0 0.1 2.5 3 0 0 3 3 3 2 Peptidase C1-like family Acyl-CoA_dh_1 PF00441.24 KOO22622.1 - 1.7e-51 174.4 1.8 3.2e-51 173.5 1.8 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOO22622.1 - 3.7e-26 92.0 0.3 2.6e-25 89.3 0.1 2.5 3 0 0 3 3 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KOO22622.1 - 4.2e-26 91.0 0.5 1.5e-25 89.3 0.3 2.1 2 0 0 2 2 1 1 Acyl-CoA dehydrogenase, middle domain Amino_oxidase PF01593.24 KOO22622.1 - 2.1e-24 86.7 0.1 2.9e-24 86.2 0.1 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Acyl-CoA_dh_2 PF08028.11 KOO22622.1 - 1.9e-20 73.5 2.0 5.6e-20 72.0 2.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain NAD_binding_8 PF13450.6 KOO22622.1 - 2.9e-14 53.0 0.3 1.8e-13 50.5 0.6 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOO22622.1 - 3.1e-11 43.0 0.0 8.9e-05 21.9 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO22622.1 - 5e-07 29.6 7.2 2.9e-06 27.1 6.5 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOO22622.1 - 8e-07 28.1 1.3 0.017 13.9 0.6 2.7 3 0 0 3 3 3 2 HI0933-like protein NAD_binding_9 PF13454.6 KOO22622.1 - 2.8e-05 24.2 1.2 0.28 11.2 0.0 2.8 3 0 0 3 3 3 2 FAD-NAD(P)-binding Thi4 PF01946.17 KOO22622.1 - 4.1e-05 22.9 0.4 9e-05 21.8 0.4 1.5 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 KOO22622.1 - 0.00033 20.1 0.2 0.00052 19.5 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HpaB_N PF11794.8 KOO22622.1 - 0.0019 17.9 0.1 0.0041 16.8 0.1 1.5 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal GIDA PF01134.22 KOO22622.1 - 0.0029 16.7 1.2 0.042 12.9 1.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 KOO22622.1 - 0.0032 16.6 2.2 0.0032 16.6 2.2 1.7 2 0 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 KOO22622.1 - 0.0038 16.5 1.5 0.011 15.1 0.8 1.9 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 KOO22622.1 - 0.0056 15.8 0.7 0.0056 15.8 0.7 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 KOO22622.1 - 0.02 15.4 0.0 0.22 12.1 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 KOO22622.1 - 0.13 11.9 0.3 0.5 10.0 0.3 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 KOO22622.1 - 0.14 12.0 0.2 0.27 11.1 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Dev_Cell_Death PF10539.9 KOO22623.1 - 1.2e-28 99.5 0.0 3.9e-28 97.9 0.0 1.9 1 1 0 1 1 1 1 Development and cell death domain HMG_box PF00505.19 KOO22623.1 - 2.5e-05 24.6 1.2 4.8e-05 23.7 1.2 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO22623.1 - 0.019 15.6 0.9 0.048 14.3 0.9 1.7 1 0 0 1 1 1 0 HMG-box domain G6PD_C PF02781.16 KOO22624.1 - 1.4e-84 283.8 0.0 1.9e-84 283.3 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 KOO22624.1 - 1.8e-47 162.3 0.0 3.1e-47 161.5 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain EF-hand_7 PF13499.6 KOO22624.1 - 7e-07 29.6 0.3 2.2e-06 28.0 0.3 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO22624.1 - 7.6e-07 28.2 0.5 6.5e-06 25.3 0.1 2.7 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 KOO22624.1 - 5e-06 26.0 0.2 4.6e-05 23.0 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO22624.1 - 0.00016 21.0 0.1 0.00045 19.6 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO22624.1 - 0.031 14.1 0.1 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair MutS_V PF00488.21 KOO22625.1 - 2.2e-43 148.5 0.1 2.5e-42 145.0 0.1 2.4 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KOO22625.1 - 9.1e-21 75.0 0.0 4.4e-20 72.7 0.0 2.2 2 0 0 2 2 2 1 MutS domain III AAA_21 PF13304.6 KOO22625.1 - 0.015 15.1 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MutS_IV PF05190.18 KOO22625.1 - 0.029 14.7 0.0 0.074 13.4 0.0 1.7 1 0 0 1 1 1 0 MutS family domain IV ATPase_2 PF01637.18 KOO22625.1 - 0.032 14.1 0.0 8.5 6.2 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 KOO22625.1 - 0.073 13.6 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOO22625.1 - 0.15 11.1 0.0 0.27 10.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF4838 PF16126.5 KOO22625.1 - 0.18 11.2 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4838) Glyco_transf_34 PF05637.12 KOO22626.1 - 9.7e-14 51.7 0.1 1.9e-08 34.3 0.2 2.1 1 1 0 2 2 2 2 galactosyl transferase GMA12/MNN10 family Pkinase PF00069.25 KOO22627.1 - 1.1e-56 192.2 0.0 1.5e-56 191.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22627.1 - 7.3e-40 136.9 0.0 1.1e-39 136.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase VHP PF02209.19 KOO22627.1 - 6.8e-07 29.2 0.0 1.4e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Villin headpiece domain Kinase-like PF14531.6 KOO22627.1 - 0.00017 21.0 0.1 0.00092 18.6 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO22627.1 - 0.0042 15.9 0.0 0.0069 15.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase LRR_6 PF13516.6 KOO22627.1 - 0.022 14.8 3.5 22 5.4 0.0 5.1 5 0 0 5 5 5 0 Leucine Rich repeat Ribosomal_L11_N PF03946.14 KOO22627.1 - 0.21 11.4 1.2 0.68 9.8 0.2 2.4 2 0 0 2 2 2 0 Ribosomal protein L11, N-terminal domain ADPrib_exo_Tox PF03496.14 KOO22628.1 - 1.1e-05 24.9 0.0 0.00038 19.8 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO22628.1 - 5.7e-05 22.5 0.0 0.00052 19.4 0.0 2.2 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Atg14 PF10186.9 KOO22629.1 - 0.068 12.2 3.0 0.087 11.9 3.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Pox_A_type_inc PF04508.12 KOO22629.1 - 0.068 13.0 2.1 0.073 13.0 0.2 2.0 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat YscO PF07321.12 KOO22629.1 - 0.24 11.3 19.0 0.33 10.9 15.7 2.0 2 0 0 2 2 2 0 Type III secretion protein YscO MPS2 PF17060.5 KOO22629.1 - 0.3 10.3 2.1 0.44 9.7 2.1 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 TMF_TATA_bd PF12325.8 KOO22629.1 - 5.1 7.4 11.7 3 8.1 9.4 1.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding UIM PF02809.20 KOO22630.1 - 0.034 14.0 6.5 0.072 13.0 6.5 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif RAP80_UIM PF18282.1 KOO22630.1 - 0.035 13.9 2.4 0.061 13.1 2.4 1.3 1 0 0 1 1 1 0 RAP80 N-terminal ubiquitin interaction motif HSP70 PF00012.20 KOO22631.1 - 1.2e-255 849.4 8.1 1.2e-255 849.4 8.1 2.5 3 0 0 3 3 2 1 Hsp70 protein AAA PF00004.29 KOO22631.1 - 8.7e-93 307.7 0.0 4.7e-46 156.5 0.0 3.3 4 0 0 4 4 2 2 ATPase family associated with various cellular activities (AAA) PGM_PMM_I PF02878.16 KOO22631.1 - 3.1e-18 65.8 0.1 1.1e-07 31.6 0.0 2.9 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I AAA_lid_3 PF17862.1 KOO22631.1 - 2.2e-17 62.6 3.6 2.1e-10 40.2 1.6 4.4 5 0 0 5 5 3 2 AAA+ lid domain MreB_Mbl PF06723.13 KOO22631.1 - 2e-12 46.6 0.1 9.1e-12 44.4 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein RuvB_N PF05496.12 KOO22631.1 - 2.2e-12 47.0 0.0 3.3e-05 23.7 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain PGM_PMM_IV PF00408.20 KOO22631.1 - 7.8e-12 45.2 1.1 7.1e-11 42.1 0.3 3.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain AAA_33 PF13671.6 KOO22631.1 - 1.3e-10 41.6 6.2 2.4e-06 27.8 0.0 4.0 4 0 0 4 4 2 2 AAA domain CDC48_N PF02359.18 KOO22631.1 - 1.9e-10 40.8 0.0 8.2e-10 38.7 0.0 2.2 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 KOO22631.1 - 2.4e-10 40.8 0.0 0.001 19.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KOO22631.1 - 3.3e-09 36.9 0.0 0.00082 19.4 0.0 3.4 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KOO22631.1 - 4.7e-08 33.1 0.0 0.0078 16.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 KOO22631.1 - 2.1e-07 31.3 0.1 0.016 15.5 0.0 4.0 3 0 0 3 3 3 2 AAA domain TIP49 PF06068.13 KOO22631.1 - 2.3e-07 30.3 0.0 0.0064 15.7 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 KOO22631.1 - 4e-07 30.4 0.0 0.017 15.5 0.0 3.1 3 0 0 3 3 2 2 RNA helicase Viral_helicase1 PF01443.18 KOO22631.1 - 1.3e-06 28.3 0.0 0.012 15.4 0.0 2.6 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase PGM_PMM_III PF02880.16 KOO22631.1 - 1.4e-06 28.5 1.6 1.8e-06 28.1 0.2 2.1 2 0 0 2 2 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III AAA_16 PF13191.6 KOO22631.1 - 2.2e-06 28.2 0.1 0.00041 20.8 0.1 6.2 5 3 1 6 6 4 2 AAA ATPase domain Mg_chelatase PF01078.21 KOO22631.1 - 3.1e-06 26.7 0.5 0.089 12.2 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 KOO22631.1 - 4.1e-06 27.3 1.2 0.14 12.6 0.0 4.1 3 0 0 3 3 3 2 ABC transporter AAA_18 PF13238.6 KOO22631.1 - 5.9e-06 26.9 0.0 0.31 11.6 0.0 3.3 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KOO22631.1 - 7.8e-06 25.7 0.0 0.073 12.8 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 KOO22631.1 - 1.2e-05 25.7 7.7 0.022 15.0 0.1 4.5 4 2 0 4 4 2 2 AAA domain Molydop_binding PF01568.21 KOO22631.1 - 1.3e-05 25.2 0.1 0.00031 20.8 0.0 2.6 2 0 0 2 2 2 1 Molydopterin dinucleotide binding domain Vps4_C PF09336.10 KOO22631.1 - 4.1e-05 23.5 0.1 0.00074 19.5 0.0 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain NACHT PF05729.12 KOO22631.1 - 4.2e-05 23.5 1.6 0.47 10.4 0.1 3.8 4 0 0 4 4 4 2 NACHT domain AAA_17 PF13207.6 KOO22631.1 - 5.6e-05 23.6 0.0 0.7 10.3 0.0 3.4 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 KOO22631.1 - 0.00011 22.2 0.0 0.24 11.3 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain Bac_DnaA PF00308.18 KOO22631.1 - 0.00033 20.6 0.0 0.94 9.3 0.0 2.6 2 0 0 2 2 2 2 Bacterial dnaA protein NB-ARC PF00931.22 KOO22631.1 - 0.00035 19.8 0.9 0.72 9.0 0.0 3.3 3 0 0 3 3 2 2 NB-ARC domain Cytidylate_kin2 PF13189.6 KOO22631.1 - 0.00036 20.7 1.3 0.34 11.0 0.0 3.3 3 0 0 3 3 2 1 Cytidylate kinase-like family Parvo_NS1 PF01057.17 KOO22631.1 - 0.00043 19.4 0.3 0.13 11.3 0.1 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 KOO22631.1 - 0.00047 19.7 0.0 0.37 10.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region TsaE PF02367.17 KOO22631.1 - 0.0013 18.7 0.0 0.45 10.5 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KOO22631.1 - 0.0018 18.0 0.0 2.7 7.7 0.0 2.7 2 1 0 2 2 2 1 Sigma-54 interaction domain ATPase PF06745.13 KOO22631.1 - 0.0027 17.1 0.1 4.3 6.6 0.0 3.4 3 0 0 3 3 3 0 KaiC Zeta_toxin PF06414.12 KOO22631.1 - 0.0029 16.9 1.5 2.2 7.5 0.0 3.2 3 0 0 3 3 2 1 Zeta toxin AAA_24 PF13479.6 KOO22631.1 - 0.0031 17.3 0.0 2 8.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 KOO22631.1 - 0.0035 17.3 2.8 1 9.2 0.0 3.5 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea AAA_3 PF07726.11 KOO22631.1 - 0.0036 17.2 0.0 3.5 7.5 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 KOO22631.1 - 0.0046 16.2 0.0 0.17 11.0 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) PhoH PF02562.16 KOO22631.1 - 0.0046 16.4 0.3 4.2 6.8 0.0 3.0 3 0 0 3 3 2 0 PhoH-like protein Sigma54_activ_2 PF14532.6 KOO22631.1 - 0.0081 16.3 0.0 2.4 8.3 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF2075 PF09848.9 KOO22631.1 - 0.012 14.9 1.0 2.7 7.1 0.0 3.1 3 0 0 3 3 2 0 Uncharacterized conserved protein (DUF2075) SKI PF01202.22 KOO22631.1 - 0.069 13.3 1.2 20 5.3 0.0 3.2 3 0 0 3 3 2 0 Shikimate kinase TniB PF05621.11 KOO22631.1 - 0.088 12.2 0.1 5.9 6.3 0.0 3.2 2 1 1 3 3 3 0 Bacterial TniB protein NTPase_1 PF03266.15 KOO22631.1 - 0.11 12.4 0.1 11 5.9 0.0 2.8 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 KOO22631.1 - 0.19 12.0 3.2 12 6.2 0.0 3.9 4 0 0 4 4 2 0 AAA domain AAA_25 PF13481.6 KOO22631.1 - 0.22 11.1 11.8 7.8 6.0 0.1 5.2 4 1 1 5 5 4 0 AAA domain DUF1664 PF07889.12 KOO22631.1 - 1.2 9.2 10.9 3.3 7.8 0.7 4.2 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) SesA PF17107.5 KOO22631.1 - 2 8.6 6.4 0.62 10.3 1.7 2.6 2 0 0 2 2 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases HTH_ParB PF17762.1 KOO22631.1 - 2.1 8.3 8.7 0.14 12.0 0.2 3.4 3 0 0 3 3 2 0 HTH domain found in ParB protein Baculo_PEP_C PF04513.12 KOO22631.1 - 9.3 6.3 15.1 0.99 9.4 3.2 4.0 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Neuroparsin PF07327.11 KOO22632.1 - 0.041 14.3 0.1 0.13 12.7 0.1 1.8 1 0 0 1 1 1 0 Neuroparsin UCH PF00443.29 KOO22633.1 - 9.9e-29 100.6 0.0 1.3e-28 100.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO22633.1 - 4.5e-13 49.5 0.0 5.4e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Zn-ribbon_8 PF09723.10 KOO22633.1 - 0.11 12.6 1.1 1.9 8.7 0.6 2.5 2 0 0 2 2 2 0 Zinc ribbon domain SlyX PF04102.12 KOO22634.1 - 4.2 8.1 10.4 5 7.8 1.1 3.2 2 1 1 3 3 3 0 SlyX ubiquitin PF00240.23 KOO22636.1 - 2.8e-07 30.2 0.0 4.4e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 KOO22636.1 - 0.091 12.6 0.0 3.4 7.6 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like zf-AN1 PF01428.16 KOO22636.1 - 0.79 9.9 11.3 1.6 8.9 11.3 1.6 1 0 0 1 1 1 0 AN1-like Zinc finger Ribosomal_L18A PF01775.17 KOO22638.1 - 4.7e-43 146.1 3.2 4.7e-43 146.1 3.2 1.5 2 0 0 2 2 2 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Ferrochelatase PF00762.19 KOO22639.1 - 3.3e-88 295.8 0.0 4.7e-88 295.3 0.0 1.2 1 0 0 1 1 1 1 Ferrochelatase Rieske PF00355.26 KOO22639.1 - 7.3e-10 38.7 0.0 1.5e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 KOO22639.1 - 2.9e-06 27.2 0.0 5.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Chloroa_b-bind PF00504.21 KOO22639.1 - 0.0014 19.1 0.0 0.0029 18.2 0.0 1.5 1 0 0 1 1 1 1 Chlorophyll A-B binding protein CbiX PF01903.17 KOO22639.1 - 0.061 13.7 0.0 5 7.5 0.0 2.6 2 0 0 2 2 2 0 CbiX EccE PF11203.8 KOO22639.1 - 0.076 13.4 1.8 0.22 11.9 0.6 2.4 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE DUF4787 PF16029.5 KOO22640.1 - 0.099 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4787) UPF0181 PF03701.14 KOO22640.1 - 0.16 11.6 1.5 4 7.1 0.3 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0181) NUDIX PF00293.28 KOO22643.1 - 1.6e-15 57.3 0.4 2.8e-15 56.5 0.4 1.3 1 0 0 1 1 1 1 NUDIX domain zf-NADH-PPase PF09297.11 KOO22643.1 - 1.6e-05 24.5 4.8 1.6e-05 24.5 4.8 2.3 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain OrfB_Zn_ribbon PF07282.11 KOO22643.1 - 0.031 14.2 2.0 0.065 13.2 2.0 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn_Tnp_IS91 PF14319.6 KOO22643.1 - 0.12 12.4 0.6 0.26 11.4 0.6 1.5 1 0 0 1 1 1 0 Transposase zinc-binding domain GRIP PF01465.20 KOO22645.1 - 3.7e-12 45.9 0.2 7.3e-12 45.0 0.2 1.6 1 0 0 1 1 1 1 GRIP domain ACCA PF03255.14 KOO22645.1 - 0.11 12.4 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit COPI_assoc PF08507.10 KOO22646.1 - 1.9 8.6 6.4 0.29 11.2 1.1 2.2 2 0 0 2 2 2 0 COPI associated protein tRNA_edit PF04073.15 KOO22648.1 - 5.9e-25 87.7 0.1 1.2e-24 86.7 0.1 1.5 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain HGTP_anticodon PF03129.20 KOO22648.1 - 1.3e-20 73.3 0.0 3.1e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain ProRS-C_1 PF09180.11 KOO22648.1 - 1.4e-20 73.2 1.6 3.1e-20 72.1 0.2 2.4 3 0 0 3 3 3 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 KOO22648.1 - 3.5e-17 62.9 0.0 6.4e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Sel1 PF08238.12 KOO22649.1 - 3.1e-41 138.9 55.0 2.8e-07 31.0 0.7 8.4 9 0 0 9 9 9 7 Sel1 repeat TPR_1 PF00515.28 KOO22651.1 - 3.2e-08 33.0 2.7 0.0086 15.9 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO22651.1 - 1.3e-05 25.0 3.7 0.058 13.5 3.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO22651.1 - 0.00079 19.7 4.8 0.0038 17.5 4.8 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO22651.1 - 0.018 15.1 1.8 0.64 10.2 1.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2239 PF09998.9 KOO22651.1 - 0.041 13.7 0.2 0.082 12.7 0.2 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2239) TPR_16 PF13432.6 KOO22651.1 - 0.68 10.6 5.2 1.3 9.7 3.4 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22651.1 - 3.7 8.6 5.7 7.8 7.6 1.2 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat Methyltransf_23 PF13489.6 KOO22652.1 - 2e-13 50.5 0.0 2.9e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22652.1 - 1.3e-11 45.1 0.0 2.3e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO22652.1 - 2.9e-09 36.6 0.0 3.8e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 KOO22652.1 - 3.1e-09 37.4 0.0 5.4e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO22652.1 - 1.7e-08 34.4 0.0 2.6e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO22652.1 - 1.9e-08 34.9 0.0 3.1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PTS_IIA PF02255.16 KOO22652.1 - 0.029 14.4 0.6 0.046 13.8 0.6 1.3 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit SBBP PF06739.11 KOO22654.1 - 4.8e-16 58.5 89.1 0.0038 17.2 0.6 12.5 13 0 0 13 13 13 9 Beta-propeller repeat DUF3712 PF12505.8 KOO22654.1 - 7.6e-06 26.2 0.6 18 5.6 0.0 7.6 10 0 0 10 10 10 1 Protein of unknown function (DUF3712) Rab5-bind PF09311.11 KOO22654.1 - 0.005 16.3 9.5 0.0071 15.8 9.5 1.1 1 0 0 1 1 1 1 Rabaptin-like protein DUF3086 PF11285.8 KOO22654.1 - 0.096 11.8 2.8 0.13 11.3 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) Phage_GP20 PF06810.11 KOO22654.1 - 0.13 12.1 6.2 0.23 11.3 6.2 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF5082 PF16888.5 KOO22654.1 - 8.5 6.7 7.7 27 5.1 6.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) LRR_6 PF13516.6 KOO22656.1 - 2.7e-46 151.7 25.0 0.00017 21.4 0.0 12.8 12 1 1 13 13 13 11 Leucine Rich repeat PhzC-PhzF PF02567.16 KOO22656.1 - 8e-27 94.4 0.0 1.5e-26 93.5 0.0 1.4 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein LRR_1 PF00560.33 KOO22656.1 - 0.0004 20.5 0.0 14 6.7 0.0 5.7 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_4 PF12799.7 KOO22656.1 - 0.00083 19.7 2.1 15 6.2 0.0 5.4 6 1 0 6 6 6 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO22656.1 - 0.22 11.3 8.5 28 4.6 0.0 5.8 5 2 0 5 5 5 0 Leucine rich repeat EIF_2_alpha PF07541.12 KOO22656.1 - 0.34 11.0 2.9 16 5.6 0.7 3.7 2 1 0 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit HOASN PF14515.6 KOO22656.1 - 1.8 9.0 19.3 8.7 6.8 0.7 6.2 2 1 5 8 8 8 0 Haem-oxygenase-associated N-terminal helices CbiG_N PF11760.8 KOO22656.1 - 7.1 6.7 32.6 13 5.8 0.1 8.2 6 2 2 9 9 9 0 Cobalamin synthesis G N-terminal DivIVA PF05103.13 KOO22657.1 - 0.0065 16.5 0.6 0.008 16.3 0.6 1.1 1 0 0 1 1 1 1 DivIVA protein PH PF00169.29 KOO22658.1 - 1e-20 74.2 0.0 4.1e-09 36.9 0.0 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 KOO22658.1 - 0.0031 17.9 0.9 1.2 9.5 0.1 3.1 3 1 0 3 3 3 2 Pleckstrin homology domain ATG16 PF08614.11 KOO22658.1 - 0.024 14.8 0.3 0.047 13.9 0.3 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Mito_carr PF00153.27 KOO22659.1 - 1.5e-11 44.1 8.3 0.00023 21.0 0.7 4.7 3 2 0 3 3 3 3 Mitochondrial carrier protein Barstar PF01337.18 KOO22659.1 - 0.043 13.8 0.1 0.1 12.6 0.1 1.6 1 0 0 1 1 1 0 Barstar (barnase inhibitor) DGF-1_C PF11040.8 KOO22659.1 - 0.34 10.9 5.0 4.6 7.3 0.3 3.1 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus AAA_16 PF13191.6 KOO22660.1 - 0.034 14.5 1.5 0.074 13.4 0.6 2.0 2 0 0 2 2 2 0 AAA ATPase domain DpaA_N PF16924.5 KOO22660.1 - 0.12 12.5 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain Annexin PF00191.20 KOO22661.1 - 2.4e-54 181.3 0.1 2.8e-10 40.1 0.1 7.8 7 1 0 7 7 7 7 Annexin DUF3500 PF12006.8 KOO22661.1 - 0.091 12.2 0.0 15 4.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3500) DUF4359 PF14271.6 KOO22661.1 - 0.14 12.9 1.0 0.57 11.0 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4359) Ion_trans PF00520.31 KOO22662.1 - 2.3e-21 76.2 7.7 3.3e-21 75.6 6.3 1.9 2 0 0 2 2 2 1 Ion transport protein DUF4131 PF13567.6 KOO22662.1 - 0.66 9.6 5.8 2 8.0 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF2207 PF09972.9 KOO22662.1 - 5 5.8 7.4 12 4.5 0.0 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Alginate_lyase PF05426.12 KOO22664.1 - 0.064 12.8 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Alginate lyase Homeodomain PF00046.29 KOO22665.1 - 4.5e-18 64.8 1.4 6.7e-18 64.3 1.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOO22665.1 - 7.8e-05 22.5 0.2 0.00013 21.7 0.2 1.3 1 0 0 1 1 1 1 Homeobox KN domain DUF4611 PF15387.6 KOO22665.1 - 0.0047 17.1 0.1 0.0073 16.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) Pilus_CpaD PF09476.10 KOO22665.1 - 0.052 13.3 0.1 0.1 12.3 0.1 1.4 1 1 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) PALP PF00291.25 KOO22666.1 - 3.6e-12 46.3 0.0 7.4e-12 45.3 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme eIF3_subunit PF08597.10 KOO22667.1 - 0.025 14.5 7.3 0.032 14.2 7.3 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit EMP24_GP25L PF01105.24 KOO22667.1 - 0.098 12.6 3.5 3.3 7.6 0.9 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD CHDCT2 PF08074.11 KOO22667.1 - 1.6 8.8 5.5 5.4 7.2 5.5 1.8 1 1 0 1 1 1 0 CHDCT2 (NUC038) domain DUF4337 PF14235.6 KOO22667.1 - 4.3 7.4 8.1 4 7.5 6.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) APG6_N PF17675.1 KOO22667.1 - 4.7 7.7 16.3 8.4 6.9 9.7 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Gelsolin PF00626.22 KOO22668.1 - 1.2e-28 98.8 0.0 8.6e-12 44.8 0.0 3.3 3 0 0 3 3 3 3 Gelsolin repeat ZT_dimer PF16916.5 KOO22668.1 - 8e-11 41.9 0.0 1.5e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter IQ PF00612.27 KOO22668.1 - 0.083 12.7 0.0 0.26 11.2 0.0 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Aminotran_4 PF01063.19 KOO22669.1 - 3e-27 95.9 0.0 4e-27 95.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Filamin PF00630.19 KOO22670.1 - 3.7e-30 104.8 0.3 3.8e-06 27.6 0.1 5.3 4 1 0 4 4 4 4 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO22670.1 - 2.7e-05 24.4 3.3 0.045 14.1 0.3 3.4 3 0 0 3 3 3 2 Invasin, domain 3 DnaJ PF00226.31 KOO22671.1 - 3.9e-18 65.3 0.1 8e-18 64.3 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Kinesin PF00225.23 KOO22672.1 - 4.4e-44 150.8 0.0 3.8e-24 85.2 0.0 2.3 2 1 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KOO22672.1 - 2.7e-08 33.9 0.0 4.7e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding SAM_2 PF07647.17 KOO22672.1 - 0.00066 19.7 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF87 PF01935.17 KOO22672.1 - 0.0039 17.3 0.0 0.0096 16.0 0.0 1.6 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_16 PF13191.6 KOO22672.1 - 0.018 15.4 0.7 0.018 15.4 0.7 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KOO22672.1 - 0.027 14.8 0.0 0.075 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain SAM_PNT PF02198.16 KOO22672.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain AAA_7 PF12775.7 KOO22672.1 - 0.25 10.8 0.0 0.47 9.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF1471 PF07338.13 KOO22672.1 - 0.31 11.0 3.9 0.82 9.7 3.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1471) Spc7 PF08317.11 KOO22673.1 - 0.0004 19.4 7.3 0.0004 19.4 7.3 8.9 3 1 5 9 9 9 3 Spc7 kinetochore protein PKcGMP_CC PF16808.5 KOO22673.1 - 0.16 11.8 0.0 0.16 11.8 0.0 10.1 9 0 0 9 9 9 0 Coiled-coil N-terminus of cGMP-dependent protein kinase BPL_N PF09825.9 KOO22674.1 - 0.013 14.6 1.2 0.014 14.5 1.2 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF885 PF05960.11 KOO22674.1 - 0.028 14.1 2.7 0.034 13.8 2.7 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) DUF2853 PF11015.8 KOO22674.1 - 0.099 13.3 1.4 0.24 12.1 0.4 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2853) RPN1_C PF18051.1 KOO22674.1 - 0.12 12.5 0.2 0.34 11.0 0.2 1.8 1 0 0 1 1 1 0 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal eIF-4B PF06273.11 KOO22674.1 - 0.15 11.1 1.4 0.16 11.0 1.4 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B YgaB PF14182.6 KOO22674.1 - 0.33 11.4 9.0 0.17 12.3 0.7 2.6 1 1 1 2 2 2 0 YgaB-like protein Tropomyosin PF00261.20 KOO22674.1 - 0.38 10.1 15.2 0.46 9.8 13.0 1.9 1 1 1 2 2 2 0 Tropomyosin HAUS6_N PF14661.6 KOO22674.1 - 7.1 6.1 11.2 0.46 10.0 1.4 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus UAA PF08449.11 KOO22675.1 - 1.1e-49 169.4 11.4 1.4e-49 169.0 11.4 1.1 1 0 0 1 1 1 1 UAA transporter family DUF2619 PF10942.8 KOO22675.1 - 0.024 14.7 5.7 0.27 11.3 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2619) Phage_holin_1 PF04531.13 KOO22675.1 - 0.37 11.3 1.8 5.4 7.6 0.0 3.3 3 2 0 3 3 3 0 Bacteriophage holin EF-hand_6 PF13405.6 KOO22676.1 - 7.9e-31 103.3 15.6 3.5e-06 26.5 0.6 5.4 5 0 0 5 5 5 5 EF-hand domain EF-hand_1 PF00036.32 KOO22676.1 - 8.4e-28 93.8 16.6 3.9e-06 26.0 0.2 5.3 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 KOO22676.1 - 7.3e-24 84.0 12.2 4.5e-10 39.8 0.1 3.7 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO22676.1 - 1.5e-21 76.0 4.2 1.1e-06 28.3 0.2 3.8 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO22676.1 - 4e-17 60.9 21.0 3.9e-05 22.9 0.3 5.3 5 0 0 5 5 5 5 EF hand Caleosin PF05042.13 KOO22676.1 - 0.0042 17.0 1.8 32 4.4 0.1 4.6 3 2 2 5 5 5 0 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO22676.1 - 0.019 15.3 4.9 4.6 7.6 1.4 3.7 2 2 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO22676.1 - 0.032 14.6 0.5 15 6.0 0.0 3.8 4 1 0 4 4 4 0 EF-hand domain DUF2666 PF10869.8 KOO22676.1 - 0.033 14.4 0.7 20 5.4 0.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2666) DUF1456 PF07308.13 KOO22676.1 - 0.094 13.1 0.3 3 8.2 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1456) Sigma70_r1_1 PF03979.14 KOO22676.1 - 1.3 9.1 7.3 26 4.9 0.0 4.3 5 0 0 5 5 5 0 Sigma-70 factor, region 1.1 RbsD_FucU PF05025.13 KOO22677.1 - 6.9e-11 42.7 0.0 7.5e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 RbsD / FucU transport protein family Methyltransf_25 PF13649.6 KOO22679.1 - 0.00098 19.8 0.0 0.002 18.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO22679.1 - 0.082 13.6 0.0 0.17 12.6 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain CTP_transf_like PF01467.26 KOO22680.1 - 2.9e-12 47.0 0.0 4.1e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like GGACT PF06094.12 KOO22681.1 - 1e-05 26.1 0.0 1.3e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Pkinase PF00069.25 KOO22683.1 - 1.5e-40 139.2 0.0 2.3e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22683.1 - 8.3e-28 97.4 0.0 1.3e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO22683.1 - 1.4e-07 30.6 0.0 2e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase ADH_zinc_N PF00107.26 KOO22684.1 - 8.8e-12 45.1 0.0 1.5e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOO22684.1 - 1.7e-11 45.3 0.0 4e-11 44.1 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 KOO22684.1 - 1.3e-05 25.0 0.0 2.6e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_N PF08240.12 KOO22684.1 - 0.0069 16.3 0.0 0.015 15.1 0.0 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_16 PF10294.9 KOO22684.1 - 0.087 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase TIG PF01833.24 KOO22685.1 - 0.0003 20.8 0.0 0.013 15.5 0.0 2.9 2 1 0 2 2 2 1 IPT/TIG domain Sugar_tr PF00083.24 KOO22686.1 - 3.9e-85 286.4 17.0 4.8e-85 286.1 17.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO22686.1 - 3.7e-16 59.0 59.8 6.5e-14 51.6 34.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOO22686.1 - 0.00074 18.5 0.2 0.00074 18.5 0.2 2.4 3 0 0 3 3 3 1 MFS_1 like family Peptidase_C1 PF00112.23 KOO22687.1 - 1.4e-35 123.4 7.9 2e-35 122.8 7.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KOO22687.1 - 0.0059 15.4 0.1 0.0096 14.7 0.1 1.2 1 0 0 1 1 1 1 Peptidase C1-like family ShK PF01549.24 KOO22688.1 - 2.2e-43 146.5 78.3 2.6e-08 34.3 4.5 6.1 6 0 0 6 6 6 6 ShK domain-like EF-hand_6 PF13405.6 KOO22689.1 - 1.7e-72 233.2 50.8 9.5e-06 25.2 0.0 19.4 19 0 0 19 19 19 16 EF-hand domain EF-hand_7 PF13499.6 KOO22689.1 - 6.5e-64 212.3 42.1 2.3e-09 37.6 0.7 12.7 9 2 6 15 15 15 15 EF-hand domain pair EF-hand_1 PF00036.32 KOO22689.1 - 1.2e-63 206.0 71.8 3.3e-05 23.1 0.0 19.1 19 0 0 19 19 19 14 EF hand EF-hand_8 PF13833.6 KOO22689.1 - 4.1e-33 113.0 59.7 1.5e-05 24.8 0.7 16.6 11 7 7 18 18 18 10 EF-hand domain pair EF-hand_5 PF13202.6 KOO22689.1 - 1.5e-32 109.6 70.0 0.015 14.8 0.8 16.7 17 0 0 17 17 17 15 EF hand Abhydrolase_2 PF02230.16 KOO22689.1 - 6.1e-10 39.3 0.0 1.2e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase p25-alpha PF05517.12 KOO22689.1 - 7.7e-09 35.9 10.4 0.22 11.7 0.5 6.5 7 0 0 7 7 7 3 p25-alpha EF-hand_10 PF14788.6 KOO22689.1 - 0.00071 19.4 16.4 6.5 6.7 0.0 9.6 9 2 1 10 10 10 1 EF hand Peptidase_S9 PF00326.21 KOO22689.1 - 0.0015 18.0 0.0 0.0057 16.2 0.0 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family Caleosin PF05042.13 KOO22689.1 - 0.011 15.7 13.8 10 6.0 0.0 7.2 8 1 1 9 9 9 0 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO22689.1 - 0.019 15.3 12.1 0.84 10.0 0.0 6.6 6 3 2 8 8 8 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO22689.1 - 0.026 14.4 13.7 3.9 7.5 0.0 7.0 6 2 0 6 6 6 0 Cytoskeletal-regulatory complex EF hand DLH PF01738.18 KOO22689.1 - 0.043 13.4 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family APOBEC3 PF18771.1 KOO22689.1 - 0.071 13.2 0.0 0.57 10.3 0.0 2.2 2 0 0 2 2 2 0 APOBEC3 LIP PF03583.14 KOO22689.1 - 0.14 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Secretory lipase FRG1 PF06229.12 KOO22689.1 - 0.15 11.8 10.4 0.56 9.9 1.7 2.6 2 0 0 2 2 2 0 FRG1-like domain DRY_EERY PF09750.9 KOO22689.1 - 0.21 11.8 2.7 11 6.3 0.1 3.3 3 0 0 3 3 3 0 Alternative splicing regulator BPL_LplA_LipB_2 PF16917.5 KOO22689.1 - 0.23 11.0 1.1 0.61 9.6 0.0 2.3 3 0 0 3 3 3 0 Biotin/lipoate A/B protein ligase family EF-hand_7 PF13499.6 KOO22691.1 - 6.5e-24 84.2 21.0 1.1e-06 29.0 0.5 7.4 5 3 1 6 6 6 6 EF-hand domain pair EF-hand_6 PF13405.6 KOO22691.1 - 3.2e-23 79.6 18.0 0.0077 16.1 0.1 8.3 8 0 0 8 8 8 6 EF-hand domain EF-hand_1 PF00036.32 KOO22691.1 - 1.3e-21 74.4 16.3 0.0014 18.0 0.0 8.4 8 0 0 8 8 8 6 EF hand EF-hand_5 PF13202.6 KOO22691.1 - 3e-12 45.4 11.4 0.28 10.8 0.0 7.1 7 0 0 7 7 7 5 EF hand EF-hand_8 PF13833.6 KOO22691.1 - 2.8e-09 36.7 21.9 0.0087 15.9 1.4 7.3 6 3 2 8 8 8 4 EF-hand domain pair GPHH PF16905.5 KOO22691.1 - 0.041 13.6 0.0 4.8 7.0 0.0 3.1 3 0 0 3 3 3 0 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_10 PF14788.6 KOO22691.1 - 0.042 13.7 0.2 44 4.0 0.0 4.3 4 1 0 4 4 4 0 EF hand HrcA PF01628.21 KOO22691.1 - 0.16 11.8 2.9 0.8 9.6 0.3 2.8 2 1 1 3 3 3 0 HrcA protein C terminal domain Metallophos PF00149.28 KOO22692.1 - 7.8e-05 23.3 0.0 0.00013 22.6 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Lumazine_bd_2 PF12893.7 KOO22693.1 - 4.2e-23 82.2 0.0 4.8e-12 46.6 0.0 3.4 2 2 0 2 2 2 2 Putative lumazine-binding DUF4440 PF14534.6 KOO22693.1 - 0.0036 17.7 0.0 0.078 13.4 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4440) Pkinase PF00069.25 KOO22694.1 - 1.8e-20 73.4 0.0 6.6e-12 45.4 0.1 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22694.1 - 1.4e-08 34.3 0.2 3e-08 33.3 0.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase CS PF04969.16 KOO22694.1 - 0.0007 20.6 0.0 0.0013 19.7 0.0 1.5 1 0 0 1 1 1 1 CS domain Trypan_PARP PF05887.11 KOO22694.1 - 0.0023 17.9 23.4 0.0023 17.9 23.4 4.3 4 0 0 4 4 4 2 Procyclic acidic repetitive protein (PARP) Thioredoxin_7 PF13899.6 KOO22695.1 - 0.024 14.8 0.0 0.043 14.0 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin PF00085.20 KOO22695.1 - 0.078 13.0 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin GPS PF01825.21 KOO22698.1 - 7.4e-09 36.0 5.6 1.4e-08 35.1 5.6 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HTH_47 PF16221.5 KOO22698.1 - 0.22 11.1 0.6 0.56 9.8 0.6 1.6 1 0 0 1 1 1 0 winged helix-turn-helix Gp_dh_C PF02800.20 KOO22698.1 - 7.1 6.2 10.1 8.6 5.9 2.4 2.5 1 1 2 3 3 3 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain zf-C3HC4_3 PF13920.6 KOO22699.1 - 2.6e-07 30.4 11.3 2.6e-07 30.4 11.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO22699.1 - 1.9e-05 24.9 16.5 4.3e-05 23.8 14.4 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 KOO22699.1 - 0.00017 21.5 11.9 0.00017 21.5 11.9 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOO22699.1 - 0.00023 20.9 11.8 0.00023 20.9 11.8 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO22699.1 - 0.00091 19.0 13.4 0.00091 19.0 13.4 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO22699.1 - 0.001 19.0 12.0 0.001 19.0 12.0 2.1 2 0 0 2 2 2 1 RING-type zinc-finger PA PF02225.22 KOO22699.1 - 0.0034 17.4 2.0 0.0079 16.2 2.0 1.6 1 0 0 1 1 1 1 PA domain Helicase_C PF00271.31 KOO22699.1 - 0.0093 16.3 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Prok-RING_4 PF14447.6 KOO22699.1 - 0.016 15.1 12.6 0.074 12.9 12.8 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF1192 PF06698.11 KOO22699.1 - 0.11 12.5 2.6 0.26 11.3 2.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) zf-C3HC4_5 PF17121.5 KOO22699.1 - 1.2 9.0 11.9 3.4 7.6 11.9 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1644 PF07800.12 KOO22699.1 - 5.3 7.1 12.1 0.97 9.5 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) THUMP PF02926.17 KOO22701.1 - 2.3e-10 40.7 0.0 3.1e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 THUMP domain Chloroa_b-bind PF00504.21 KOO22702.1 - 1.4e-08 35.5 0.5 2.3e-08 34.7 0.4 1.4 1 1 0 1 1 1 1 Chlorophyll A-B binding protein LigA PF07746.11 KOO22702.1 - 0.12 12.6 0.2 0.25 11.5 0.0 1.6 2 0 0 2 2 2 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit EF-hand_6 PF13405.6 KOO22703.1 - 9.6e-15 53.2 1.6 0.0021 17.8 0.2 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO22703.1 - 1.1e-14 52.7 2.6 8.6e-05 21.8 0.7 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO22703.1 - 5.7e-14 52.3 0.4 3.7e-06 27.3 0.0 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO22703.1 - 4.1e-10 38.7 2.3 0.0011 18.3 0.6 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO22703.1 - 1.3e-07 31.3 3.0 0.043 13.7 0.5 4.3 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 KOO22703.1 - 5.2e-06 26.4 0.1 0.0016 18.3 0.0 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO22703.1 - 6.5e-05 23.2 0.1 0.023 15.0 0.0 2.8 2 1 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO22703.1 - 0.094 13.0 0.2 9.3 6.6 0.0 2.6 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Pkinase PF00069.25 KOO22704.1 - 1.7e-58 198.1 0.0 2.1e-58 197.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22704.1 - 5.7e-30 104.5 0.0 6.8e-30 104.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO22704.1 - 5.4e-11 41.9 0.0 7.3e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO22704.1 - 2.9e-08 33.4 0.0 2.9e-07 30.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOO22704.1 - 1.3e-06 28.6 0.0 0.0046 16.9 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KOO22704.1 - 0.015 14.6 0.1 0.02 14.3 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PqqD PF05402.12 KOO22704.1 - 0.029 14.7 0.0 0.047 14.0 0.0 1.3 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) Aminotran_3 PF00202.21 KOO22705.1 - 7.3e-31 107.2 0.0 1e-30 106.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 KOO22705.1 - 0.066 12.4 0.1 0.16 11.1 0.0 1.6 2 0 0 2 2 2 0 Aminotransferase class I and II ATG16 PF08614.11 KOO22705.1 - 0.18 12.0 2.1 0.32 11.2 2.1 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ketoacyl-synt PF00109.26 KOO22706.1 - 3.3e-08 33.4 0.2 7.7e-08 32.2 0.2 1.6 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Pkinase PF00069.25 KOO22707.1 - 2.9e-11 43.2 0.0 1.5e-10 40.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 KOO22707.1 - 2.3e-05 23.4 0.0 3.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO22707.1 - 0.0001 21.7 0.0 0.00015 21.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO22707.1 - 0.0016 18.4 0.0 0.0036 17.3 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 KOO22707.1 - 0.034 13.4 0.0 0.093 12.0 0.0 1.6 1 1 0 1 1 1 0 Protein tyrosine kinase Rieske PF00355.26 KOO22708.1 - 5.6e-18 64.7 0.0 1.1e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PaO PF08417.12 KOO22708.1 - 3.2e-17 62.4 0.0 1e-16 60.8 0.0 1.9 2 0 0 2 2 2 1 Pheophorbide a oxygenase FA_desaturase PF00487.24 KOO22710.1 - 2.1e-13 50.7 1.7 2.6e-13 50.4 1.7 1.1 1 0 0 1 1 1 1 Fatty acid desaturase ShK PF01549.24 KOO22711.1 - 3.4e-35 120.3 61.6 2.1e-10 40.9 7.0 5.1 5 0 0 5 5 5 5 ShK domain-like NYD-SP28 PF14772.6 KOO22712.1 - 2e-18 66.3 17.9 2e-18 66.3 17.9 5.2 3 2 1 5 5 5 1 Sperm tail NYD-SP28_assoc PF14775.6 KOO22712.1 - 1.8e-09 37.5 0.0 1.8e-09 37.5 0.0 3.6 4 0 0 4 4 4 1 Sperm tail C-terminal domain Lectin_N PF03954.14 KOO22712.1 - 1.2 8.9 5.8 0.65 9.7 1.4 2.7 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain Pox_LP_H2 PF03356.15 KOO22712.1 - 1.9 8.3 4.9 0.72 9.7 0.7 2.3 2 0 0 2 2 2 0 Viral late protein H2 zf-C2H2_3rep PF18868.1 KOO22712.1 - 6.1 7.5 6.3 3.4 8.3 1.0 2.9 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats Choline_transpo PF04515.12 KOO22713.1 - 2.3e-50 171.7 15.0 5e-50 170.5 11.9 2.1 2 0 0 2 2 2 2 Plasma-membrane choline transporter tRNA-synt_1c PF00749.21 KOO22715.1 - 2.2e-101 338.9 0.0 2.8e-101 338.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KOO22715.1 - 6.7e-57 192.1 0.0 1.1e-56 191.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain CLASP_N PF12348.8 KOO22717.1 - 5e-17 62.2 0.3 6.6e-17 61.8 0.3 1.1 1 0 0 1 1 1 1 CLASP N terminal HEAT_2 PF13646.6 KOO22717.1 - 0.006 16.9 13.2 0.035 14.5 2.0 3.5 1 1 3 4 4 4 4 HEAT repeats Apolipoprotein PF01442.18 KOO22717.1 - 0.048 13.5 3.7 0.48 10.3 0.7 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF4148 PF13663.6 KOO22717.1 - 1.8 8.8 6.9 0.12 12.6 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) HEAT PF02985.22 KOO22717.1 - 2.1 8.8 14.7 1.3 9.4 0.3 5.5 5 2 1 6 6 6 0 HEAT repeat WD40 PF00400.32 KOO22718.1 - 1.3e-10 41.7 5.5 0.00027 21.7 0.7 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO22718.1 - 0.0065 16.7 0.4 8 6.8 0.0 3.7 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Lipase_3 PF01764.25 KOO22720.1 - 9.9e-25 87.1 0.0 1.4e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Defensin_2 PF01097.18 KOO22720.1 - 2.7 8.0 10.1 0.68 9.9 5.9 2.1 2 0 0 2 2 2 0 Arthropod defensin TrkA_N PF02254.18 KOO22721.1 - 0.11 12.8 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain EF-hand_7 PF13499.6 KOO22722.1 - 4.1e-11 43.2 3.5 2.6e-06 27.8 0.2 2.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO22722.1 - 1.3e-07 30.9 0.3 0.0089 15.9 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO22722.1 - 2.4e-07 29.8 2.5 0.0021 17.5 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO22722.1 - 1.8e-05 24.0 5.4 0.026 14.0 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO22722.1 - 0.013 15.3 0.9 3.5 7.5 0.3 2.3 2 0 0 2 2 2 0 EF-hand domain pair PCIF1_WW PF12237.8 KOO22723.1 - 3.1e-51 173.4 0.0 4.3e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain Pkinase PF00069.25 KOO22724.1 - 2.8e-32 112.1 0.0 3.7e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22724.1 - 1.7e-14 53.7 0.0 2.2e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO22724.1 - 0.046 13.0 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like EF-hand_1 PF00036.32 KOO22725.1 - 0.006 16.1 0.2 0.085 12.4 0.0 2.4 2 0 0 2 2 2 1 EF hand TPR_9 PF13371.6 KOO22726.1 - 8.3e-11 41.9 4.3 9e-06 25.8 0.2 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO22726.1 - 1.2e-06 28.1 6.2 0.0017 18.1 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO22726.1 - 3.6e-05 23.5 15.4 0.0045 17.0 0.1 3.9 4 0 0 4 4 3 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO22726.1 - 0.00057 19.9 0.0 1.2 9.3 0.0 2.6 2 1 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 KOO22726.1 - 0.0015 18.2 1.9 0.16 11.6 0.1 2.5 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 KOO22726.1 - 0.0064 16.8 2.8 2 9.0 0.3 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO22726.1 - 0.025 14.9 1.7 0.061 13.6 1.7 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat BTAD PF03704.17 KOO22726.1 - 0.11 12.9 5.1 1.6 9.2 0.1 2.8 3 0 0 3 3 3 0 Bacterial transcriptional activator domain ENOD40 PF08247.11 KOO22726.1 - 0.18 11.8 1.0 0.37 10.9 1.0 1.5 1 0 0 1 1 1 0 ENOD40 protein TPR_8 PF13181.6 KOO22726.1 - 0.48 10.8 8.2 2.4 8.6 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO22726.1 - 3.2 8.8 9.6 6.9 7.8 0.0 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat CBFB_NFYA PF02045.15 KOO22727.1 - 2.8e-16 59.8 5.5 5.1e-16 59.0 5.5 1.4 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DUF4201 PF13870.6 KOO22728.1 - 0.33 10.6 20.2 2.2 8.0 3.4 5.0 2 2 1 4 4 4 0 Domain of unknown function (DUF4201) Nsp1_C PF05064.13 KOO22728.1 - 2.9 7.7 21.2 2.2 8.1 2.8 4.7 3 1 2 5 5 5 0 Nsp1-like C-terminal region DUF4640 PF15480.6 KOO22729.1 - 0.86 9.3 8.1 1.2 8.9 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4640) DUF2927 PF11150.8 KOO22729.1 - 3.5 7.6 24.7 0.22 11.6 10.4 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2927) PLDc_2 PF13091.6 KOO22730.1 - 2.2e-13 50.2 0.0 7.9e-07 29.0 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 KOO22730.1 - 0.042 14.0 0.2 1.1 9.5 0.0 2.5 2 0 0 2 2 2 0 Phospholipase D Active site motif DUF3782 PF12644.7 KOO22730.1 - 0.044 13.9 0.1 0.098 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) AA_permease_2 PF13520.6 KOO22731.1 - 6.4e-36 124.1 18.9 6.4e-36 124.1 18.9 2.2 3 0 0 3 3 3 1 Amino acid permease MFS_1 PF07690.16 KOO22731.1 - 7.7e-20 71.1 48.7 2.6e-19 69.4 22.9 4.5 2 2 1 3 3 3 2 Major Facilitator Superfamily AA_permease PF00324.21 KOO22731.1 - 1.4e-17 63.5 16.0 1.4e-17 63.5 16.0 2.7 3 0 0 3 3 3 1 Amino acid permease EcKinase PF02958.20 KOO22732.1 - 2.4e-11 43.5 0.0 3.7e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 KOO22732.1 - 7.3e-07 29.3 0.1 1.2e-06 28.6 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 KOO22732.1 - 0.00017 20.6 0.0 0.00022 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) 2OG-FeII_Oxy_2 PF13532.6 KOO22733.1 - 5e-35 121.5 0.0 8.9e-35 120.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ASCH PF04266.14 KOO22733.1 - 2.4e-15 57.0 0.0 4.5e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 ASCH domain zf-C2HC5 PF06221.13 KOO22733.1 - 1.8e-11 43.8 8.2 3.7e-11 42.8 8.2 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type tRNA-synt_2 PF00152.20 KOO22734.1 - 6.2e-74 248.9 0.0 8.4e-74 248.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOO22734.1 - 2.4e-06 27.4 0.1 4.1e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOO22734.1 - 0.00034 20.2 0.1 0.078 12.4 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.6 KOO22734.1 - 0.014 15.6 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DUF1682 PF07946.14 KOO22734.1 - 0.42 9.8 3.9 0.64 9.2 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) HMG_box PF00505.19 KOO22735.1 - 2.9e-15 56.4 0.1 2.9e-15 56.4 0.1 2.5 2 1 1 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO22735.1 - 2.8e-10 40.6 0.3 2.8e-10 40.6 0.3 2.2 2 1 0 2 2 2 1 HMG-box domain TMPIT PF07851.13 KOO22735.1 - 5.9 6.0 5.1 9.8 5.3 5.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein LRR_9 PF14580.6 KOO22736.1 - 3.9e-09 36.2 0.0 1.1e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 KOO22736.1 - 8e-09 35.1 1.4 3.3e-08 33.2 1.4 2.2 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KOO22736.1 - 3e-05 24.3 3.1 9.2e-05 22.7 0.1 2.9 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) IQ PF00612.27 KOO22736.1 - 0.045 13.5 28.1 0.052 13.4 0.1 5.7 6 0 0 6 6 6 0 IQ calmodulin-binding motif Glyco_hydro_43 PF04616.14 KOO22737.1 - 2.1e-06 27.2 0.1 3e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Ricin_B_lectin PF00652.22 KOO22737.1 - 0.065 13.5 0.0 0.17 12.1 0.0 1.6 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain Bromodomain PF00439.25 KOO22738.1 - 6.4e-43 144.7 0.0 6.8e-21 74.1 0.0 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 KOO22738.1 - 9.9e-09 35.3 0.0 1.9e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Herpes_PAP PF03325.13 KOO22738.1 - 0.092 12.3 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus polymerase accessory protein Rx_N PF18052.1 KOO22739.1 - 0.093 13.0 0.0 0.093 13.0 0.0 3.9 3 1 1 4 4 4 0 Rx N-terminal domain Vac_Fusion PF02346.16 KOO22739.1 - 0.15 11.7 0.2 0.45 10.2 0.2 1.8 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 PCRF PF03462.18 KOO22740.1 - 0.0016 18.4 0.1 0.0034 17.3 0.1 1.5 1 1 0 1 1 1 1 PCRF domain IATP PF04568.12 KOO22740.1 - 0.037 14.4 1.0 0.07 13.6 1.0 1.4 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Taq-exonuc PF09281.10 KOO22740.1 - 0.045 13.7 0.4 0.1 12.6 0.4 1.6 1 0 0 1 1 1 0 Taq polymerase, exonuclease Cwf_Cwc_15 PF04889.12 KOO22740.1 - 0.11 12.3 1.2 0.16 11.7 1.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Exo_endo_phos PF03372.23 KOO22741.1 - 6.7e-05 22.5 1.0 0.00013 21.6 1.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family tRNA-synt_1 PF00133.22 KOO22742.1 - 3e-190 633.5 0.0 3.2e-189 630.1 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KOO22742.1 - 4.9e-38 130.5 0.0 9.8e-38 129.5 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KOO22742.1 - 2e-13 49.9 0.0 1.1e-05 24.3 0.1 4.0 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 KOO22742.1 - 9.5e-10 38.3 0.0 1.5e-05 24.6 0.0 2.4 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 KOO22742.1 - 6e-08 32.9 1.7 8.1e-08 32.4 0.2 2.0 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.19 KOO22742.1 - 0.00035 20.0 0.0 0.44 9.8 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1c PF00749.21 KOO22742.1 - 0.041 12.8 0.1 0.093 11.6 0.0 1.5 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain Pribosyltran PF00156.27 KOO22743.1 - 7.4e-11 41.8 0.0 1.7e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Trypsin_2 PF13365.6 KOO22744.1 - 1.3e-25 91.0 0.6 2.6e-25 90.1 0.6 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_3 PF17815.1 KOO22744.1 - 1.1e-17 64.3 0.0 1.6e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 PDZ domain Trypsin PF00089.26 KOO22744.1 - 1.2e-12 48.1 0.0 1.9e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.9 KOO22744.1 - 0.0028 16.4 0.8 0.013 14.2 0.8 1.8 2 0 0 2 2 2 1 Peptidase S46 CBS PF00571.28 KOO22745.1 - 1.9e-24 85.8 0.4 3.2e-11 43.5 0.1 2.7 2 0 0 2 2 2 2 CBS domain DHH PF01368.20 KOO22745.1 - 5.7e-10 39.3 0.0 1.1e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 DHH family Lactonase PF10282.9 KOO22745.1 - 0.013 14.7 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Adaptin_N PF01602.20 KOO22746.1 - 0.17 10.4 3.8 0.75 8.3 3.8 2.0 1 1 0 1 1 1 0 Adaptin N terminal region EF-hand_5 PF13202.6 KOO22747.1 - 1.5e-25 87.5 16.7 9.8e-07 28.0 0.9 4.9 5 0 0 5 5 5 4 EF hand Thioredoxin PF00085.20 KOO22747.1 - 6.9e-25 87.0 0.1 1.2e-24 86.3 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin EF-hand_6 PF13405.6 KOO22747.1 - 1.4e-24 83.9 7.5 1.3e-05 24.7 0.4 5.3 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 KOO22747.1 - 1.1e-23 81.0 11.5 3e-05 23.2 0.3 5.2 5 1 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO22747.1 - 4.3e-20 71.9 3.7 5.5e-09 36.4 0.1 3.8 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO22747.1 - 1.9e-17 62.8 5.6 1.1e-06 28.4 0.5 4.3 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO22747.1 - 8e-06 26.1 0.1 0.083 13.2 0.0 3.2 2 2 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Thioredoxin_2 PF13098.6 KOO22747.1 - 0.0014 19.1 0.2 0.012 16.1 0.2 2.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOO22747.1 - 0.0023 18.2 0.0 0.0047 17.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 KOO22747.1 - 0.0038 16.6 0.1 0.0054 16.1 0.1 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 KOO22747.1 - 0.0059 16.8 0.1 0.82 9.9 0.1 3.2 3 0 0 3 3 3 1 Glutaredoxin Thioredoxin_9 PF14595.6 KOO22747.1 - 0.0098 15.7 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 KOO22747.1 - 0.018 15.2 0.1 0.043 14.0 0.1 1.6 1 0 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.21 KOO22747.1 - 0.06 13.3 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family Dockerin_1 PF00404.18 KOO22747.1 - 0.19 12.0 0.3 0.19 12.0 0.3 4.1 4 1 1 5 5 5 0 Dockerin type I domain EF-hand_1 PF00036.32 KOO22748.1 - 2.9e-09 35.8 0.9 0.0014 18.0 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO22748.1 - 3.3e-09 37.1 0.1 8.2e-09 35.8 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO22748.1 - 1.8e-06 27.4 0.1 0.016 15.1 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO22748.1 - 1.5e-05 24.2 0.8 0.31 10.6 0.5 3.0 2 0 0 2 2 2 2 EF hand Pentapeptide_4 PF13599.6 KOO22748.1 - 3.1e-05 24.1 0.0 5.2 7.3 0.0 5.1 5 0 0 5 5 5 2 Pentapeptide repeats (9 copies) EF-hand_8 PF13833.6 KOO22748.1 - 6.6e-05 22.7 2.2 0.004 17.0 0.1 3.6 2 1 1 3 3 3 2 EF-hand domain pair SinI PF08671.10 KOO22748.1 - 0.0043 16.8 0.0 0.016 15.0 0.0 2.1 1 0 0 1 1 1 1 Anti-repressor SinI MerR-DNA-bind PF09278.11 KOO22748.1 - 0.018 15.6 5.0 49 4.6 0.4 5.4 4 0 0 4 4 4 0 MerR, DNA binding SH3_3 PF08239.11 KOO22748.1 - 0.072 13.4 0.0 0.21 11.9 0.0 1.8 1 0 0 1 1 1 0 Bacterial SH3 domain EF-hand_6 PF13405.6 KOO22749.1 - 1.5e-20 71.3 0.8 6.8e-05 22.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO22749.1 - 1.9e-17 61.4 5.5 9.4e-06 24.8 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO22749.1 - 1.4e-12 47.8 3.4 3e-05 24.4 0.3 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO22749.1 - 1.3e-09 37.1 16.2 2.6e-05 23.5 1.6 4.8 5 0 0 5 5 4 3 EF hand EF-hand_8 PF13833.6 KOO22749.1 - 1.2e-07 31.5 7.4 0.062 13.2 0.1 5.2 4 1 1 5 5 5 2 EF-hand domain pair Transcrip_act PF04949.13 KOO22749.1 - 0.0031 17.4 0.8 0.0031 17.4 0.8 2.6 3 0 0 3 3 3 1 Transcriptional activator Dockerin_1 PF00404.18 KOO22749.1 - 0.043 14.0 0.2 10 6.4 0.0 3.1 2 1 1 3 3 3 0 Dockerin type I domain Med9 PF07544.13 KOO22749.1 - 0.047 13.8 0.2 0.23 11.6 0.2 2.3 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF4618 PF15397.6 KOO22749.1 - 0.088 12.2 5.3 0.37 10.2 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) DUF3740 PF12548.8 KOO22749.1 - 0.12 12.8 0.7 0.28 11.6 0.6 1.7 1 1 0 1 1 1 0 Sulfatase protein BLOC1_2 PF10046.9 KOO22749.1 - 0.28 11.5 2.0 3.6 7.9 0.0 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Syntaxin-6_N PF09177.11 KOO22749.1 - 0.85 10.2 4.8 25 5.5 0.2 3.2 3 0 0 3 3 3 0 Syntaxin 6, N-terminal TPR_MLP1_2 PF07926.12 KOO22749.1 - 2.2 8.3 8.8 1.9 8.6 0.4 3.3 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Pyridoxal_deC PF00282.19 KOO22750.1 - 2.4e-17 62.7 0.0 3.9e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 KOO22750.1 - 9.9e-08 31.3 0.0 2.9e-07 29.8 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V Na_Ca_ex PF01699.24 KOO22751.1 - 1.2e-23 83.8 15.2 1.6e-23 83.3 15.2 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein EF-hand_7 PF13499.6 KOO22751.1 - 7e-12 45.6 0.2 2.8e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO22751.1 - 2.8e-11 42.4 0.1 0.013 15.4 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO22751.1 - 7.2e-11 40.8 0.3 0.05 13.2 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 KOO22751.1 - 6.4e-08 31.7 1.1 0.079 12.5 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO22751.1 - 0.0002 21.1 1.6 0.15 12.0 0.4 2.9 2 1 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO22751.1 - 0.0025 18.1 0.0 0.42 10.9 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF3995 PF13160.6 KOO22751.1 - 0.17 12.3 7.9 4.1 7.8 5.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) Dockerin_1 PF00404.18 KOO22751.1 - 0.27 11.5 4.8 1.8 8.8 0.3 3.3 2 1 1 3 3 3 0 Dockerin type I domain Na_Ca_ex PF01699.24 KOO22752.1 - 3.9e-22 78.8 16.4 5.8e-22 78.3 16.4 1.2 1 0 0 1 1 1 1 Sodium/calcium exchanger protein HEAT PF02985.22 KOO22753.1 - 0.00015 21.7 19.5 2.3 8.7 0.2 7.6 7 0 0 7 7 7 3 HEAT repeat Vac14_Fab1_bd PF12755.7 KOO22753.1 - 0.0063 17.1 0.0 0.78 10.4 0.0 2.8 2 1 0 2 2 2 1 Vacuolar 14 Fab1-binding region HECT PF00632.25 KOO22754.1 - 1.1e-08 34.9 0.0 5e-08 32.8 0.0 1.8 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Kelch_3 PF13415.6 KOO22755.1 - 6e-17 61.5 13.8 9.2e-06 25.8 0.1 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO22755.1 - 9.2e-17 60.8 5.3 6.9e-06 26.0 0.0 5.1 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO22755.1 - 2.5e-15 56.1 9.0 0.00023 21.1 0.0 5.1 4 1 1 5 5 5 4 Kelch motif CUB PF00431.20 KOO22755.1 - 9.1e-15 55.0 0.0 1.6e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 CUB domain Kelch_6 PF13964.6 KOO22755.1 - 2.7e-13 49.7 8.9 0.00013 22.2 0.0 5.8 4 1 2 6 6 6 4 Kelch motif Kelch_1 PF01344.25 KOO22755.1 - 1.7e-11 43.5 3.9 0.00029 20.4 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KOO22755.1 - 9.8e-09 34.9 8.5 0.043 13.8 0.0 5.4 3 1 2 5 5 5 4 Kelch motif DPM3 PF08285.11 KOO22756.1 - 2e-20 72.7 0.0 2.1e-20 72.7 0.0 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) RRM_DME PF15628.6 KOO22758.1 - 1.5e-06 28.3 0.0 3.6e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 RRM in Demeter PHD PF00628.29 KOO22758.1 - 7.8e-05 22.5 10.8 7.8e-05 22.5 10.8 2.6 2 0 0 2 2 2 1 PHD-finger HMG_box PF00505.19 KOO22758.1 - 0.00065 20.1 0.0 0.0017 18.8 0.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box Acetyltransf_1 PF00583.25 KOO22758.1 - 0.017 15.3 0.0 0.041 14.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family HMG_box_2 PF09011.10 KOO22758.1 - 0.029 15.0 0.0 0.066 13.8 0.0 1.6 1 0 0 1 1 1 0 HMG-box domain HhH-GPD PF00730.25 KOO22758.1 - 0.08 13.4 0.0 6.5 7.3 0.0 2.6 2 0 0 2 2 2 0 HhH-GPD superfamily base excision DNA repair protein Acetyltransf_7 PF13508.7 KOO22758.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO22758.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO22758.1 - 0.14 12.2 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Glyco_hydro_3 PF00933.21 KOO22760.1 - 1.4e-24 87.0 0.0 2.7e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain WW PF00397.26 KOO22761.1 - 0.0053 16.8 0.2 0.011 15.8 0.2 1.5 1 0 0 1 1 1 1 WW domain AMP-binding PF00501.28 KOO22763.1 - 1.9e-85 287.0 0.0 2.3e-85 286.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 KOO22763.1 - 1.8e-24 85.4 1.5 4.1e-24 84.3 1.5 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 KOO22763.1 - 1.5e-23 83.5 0.7 3.5e-23 82.4 0.7 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RhoGAP-FF1 PF16512.5 KOO22763.1 - 0.052 14.2 0.1 0.094 13.4 0.1 1.4 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain Nitroreductase PF00881.24 KOO22765.1 - 9.8e-17 61.5 0.0 1.3e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family Armet PF10208.9 KOO22765.1 - 0.24 11.3 0.0 0.35 10.8 0.0 1.2 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding EF-hand_7 PF13499.6 KOO22766.1 - 3.5e-16 59.4 6.6 1.2e-07 32.1 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO22766.1 - 5.6e-14 51.7 6.8 8e-12 44.8 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO22766.1 - 9.6e-12 43.8 4.8 0.00029 20.5 0.4 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO22766.1 - 6e-10 38.0 11.0 0.0061 16.0 0.2 4.3 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 KOO22766.1 - 0.0016 17.8 3.8 0.24 11.0 0.1 4.0 4 0 0 4 4 4 1 EF hand SANT_DAMP1_like PF16282.5 KOO22767.1 - 2.4e-30 104.6 0.9 4.7e-30 103.6 0.9 1.5 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 KOO22767.1 - 9.8e-07 28.8 2.0 1.1e-06 28.6 0.2 1.8 2 0 0 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-binding PF00249.31 KOO22767.1 - 0.0007 19.7 0.2 0.0032 17.6 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO22767.1 - 0.0045 17.2 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain PK_C PF02887.16 KOO22767.1 - 0.05 13.8 0.0 0.093 13.0 0.0 1.4 1 0 0 1 1 1 0 Pyruvate kinase, alpha/beta domain Myb_DNA-bind_7 PF15963.5 KOO22767.1 - 0.068 13.1 0.1 0.19 11.7 0.1 1.7 1 0 0 1 1 1 0 Myb DNA-binding like PRC2_HTH_1 PF18118.1 KOO22767.1 - 0.073 13.9 0.1 0.21 12.4 0.0 1.8 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain EF-hand_7 PF13499.6 KOO22769.1 - 4.3e-19 68.7 0.4 2.2e-11 44.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO22769.1 - 5e-18 63.2 0.7 9.6e-06 24.8 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO22769.1 - 7.6e-13 48.1 6.8 3.1e-07 30.1 0.4 4.0 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO22769.1 - 2e-11 42.8 5.8 0.015 15.2 0.0 4.7 3 2 1 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KOO22769.1 - 5.4e-11 41.5 2.6 0.0081 15.6 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KOO22769.1 - 0.0013 19.0 0.1 0.43 10.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 KOO22769.1 - 0.0039 17.2 0.1 0.012 15.6 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.7 KOO22769.1 - 0.0046 16.9 1.1 1.4 8.9 0.1 2.9 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand Ribosomal_L7Ae PF01248.26 KOO22770.1 - 2.6e-26 91.2 1.3 3.2e-26 90.9 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PFK PF00365.20 KOO22771.1 - 6.8e-56 189.7 0.2 8.2e-56 189.4 0.2 1.1 1 0 0 1 1 1 1 Phosphofructokinase DUF2475 PF10629.9 KOO22772.1 - 9.8e-12 44.9 9.5 0.038 14.2 0.0 4.4 4 0 0 4 4 4 4 Protein of unknown function (DUF2475) Pax2_C PF12403.8 KOO22772.1 - 0.15 12.1 9.3 8.6 6.5 0.2 4.0 2 2 2 4 4 4 0 Paired-box protein 2 C terminal NAGLU PF05089.12 KOO22772.1 - 0.32 9.9 1.2 15 4.4 0.0 2.8 4 0 0 4 4 4 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain Helicase_C PF00271.31 KOO22775.1 - 1.1e-15 57.9 0.0 1.6e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SHOCT PF09851.9 KOO22776.1 - 0.0024 17.5 0.9 1.1 9.1 0.1 2.7 2 0 0 2 2 2 2 Short C-terminal domain eIF_4G1 PF12152.8 KOO22776.1 - 0.0035 17.5 1.1 1 9.6 0.1 3.0 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 4G1 Glyco_hydro_39 PF01229.17 KOO22776.1 - 0.24 9.9 0.1 0.55 8.8 0.1 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 DUF3638 PF12340.8 KOO22777.1 - 1.1e-24 87.0 0.0 1.4e-23 83.4 0.0 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO22777.1 - 2.5e-15 55.6 0.3 7.2e-15 54.1 0.3 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) EF-hand_7 PF13499.6 KOO22777.1 - 3.2e-05 24.3 0.0 0.49 10.9 0.0 3.8 3 0 0 3 3 3 2 EF-hand domain pair Vps62 PF06101.11 KOO22777.1 - 0.00012 20.5 0.0 0.00022 19.7 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 Alpha_adaptin_C PF02296.16 KOO22777.1 - 0.0002 21.5 0.0 0.00045 20.4 0.0 1.6 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain EF-hand_6 PF13405.6 KOO22777.1 - 0.00034 20.3 0.1 5.9 7.1 0.0 4.8 4 0 0 4 4 4 1 EF-hand domain EF-hand_5 PF13202.6 KOO22777.1 - 0.0054 16.2 0.9 9.6 5.9 0.2 3.4 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 KOO22777.1 - 0.0071 15.8 0.1 3.2 7.5 0.0 4.1 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 KOO22777.1 - 0.11 12.4 1.6 0.75 9.7 0.0 3.1 2 1 1 3 3 3 0 EF-hand domain pair 2-Hacid_dh_C PF02826.19 KOO22778.1 - 1.2e-52 177.8 0.1 1.8e-52 177.3 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOO22778.1 - 1.7e-24 86.0 0.2 2.4e-24 85.5 0.2 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOO22778.1 - 2.3e-06 27.8 0.2 6e-06 26.5 0.2 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 KOO22778.1 - 0.00024 20.7 0.0 0.00066 19.3 0.0 1.7 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 KOO22778.1 - 0.0071 16.8 0.2 0.031 14.7 0.1 2.1 2 0 0 2 2 2 1 Putative NAD(P)-binding F420_oxidored PF03807.17 KOO22778.1 - 0.014 15.9 2.2 0.034 14.7 0.1 2.5 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 KOO22778.1 - 0.015 15.4 0.1 0.034 14.2 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.9 KOO22778.1 - 0.025 14.4 1.0 0.23 11.3 0.1 2.4 2 0 0 2 2 2 0 Rossmann-like domain Aminotran_1_2 PF00155.21 KOO22778.1 - 0.081 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Pyr_redox PF00070.27 KOO22778.1 - 0.096 13.3 1.6 0.42 11.2 1.6 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 KOO22778.1 - 0.11 12.4 0.9 0.39 10.6 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Med25_SD1 PF11235.8 KOO22778.1 - 0.29 11.4 1.7 0.54 10.6 1.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 25 synapsin 1 CH PF00307.31 KOO22779.1 - 3e-16 59.6 0.0 5.7e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 KOO22779.1 - 0.012 15.9 0.0 0.021 15.0 0.0 1.3 1 0 0 1 1 1 0 CDC24 Calponin Aa_trans PF01490.18 KOO22781.1 - 8.1e-62 209.2 21.6 9.8e-62 209.0 21.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOO22781.1 - 2.1e-09 36.9 16.9 2.5e-07 30.1 12.1 2.2 2 0 0 2 2 2 2 Tryptophan/tyrosine permease family Cnn_1N PF07989.11 KOO22782.1 - 0.002 18.3 25.1 3.6 7.8 0.3 5.2 2 2 3 5 5 5 4 Centrosomin N-terminal motif 1 SnoaL_2 PF12680.7 KOO22782.1 - 0.043 14.5 0.0 0.17 12.5 0.0 2.1 1 0 0 1 1 1 0 SnoaL-like domain KASH_CCD PF14662.6 KOO22782.1 - 0.58 9.9 34.7 2 8.2 9.5 2.7 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 KOO22782.1 - 0.69 8.7 40.9 0.044 12.7 10.9 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein TMPIT PF07851.13 KOO22782.1 - 1.2 8.3 14.6 0.64 9.2 1.3 2.7 2 1 1 3 3 3 0 TMPIT-like protein DUF4878 PF12870.7 KOO22782.1 - 2.1 8.7 5.6 0.49 10.7 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4878) DUF1664 PF07889.12 KOO22782.1 - 2.6 8.1 15.7 4.3 7.4 1.9 4.2 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Sec8_exocyst PF04048.14 KOO22782.1 - 4.6 7.1 15.1 6.3 6.7 0.6 4.0 3 1 1 4 4 4 0 Sec8 exocyst complex component specific domain FapA PF03961.13 KOO22782.1 - 5 5.6 17.5 0.67 8.5 6.7 2.3 1 1 0 2 2 2 0 Flagellar Assembly Protein A SLATT_1 PF18181.1 KOO22784.1 - 5e-07 29.7 2.0 2.5e-06 27.4 0.2 3.0 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain 1 DUF4231 PF14015.6 KOO22784.1 - 2.7e-05 24.6 0.4 2.7e-05 24.6 0.4 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF4231) ATG_C PF09333.11 KOO22784.1 - 0.16 12.4 0.1 2.5 8.5 0.0 3.1 5 0 0 5 5 5 0 Autophagy-related protein C terminal domain Cupin_4 PF08007.12 KOO22785.1 - 6.5e-33 114.5 0.0 1.1e-32 113.9 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein DEAD PF00270.29 KOO22787.1 - 2.4e-33 115.3 0.0 2.9e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.6 KOO22787.1 - 0.00023 20.6 0.2 0.0018 17.7 0.0 2.0 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 KOO22787.1 - 0.00071 19.6 0.0 0.001 19.1 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOO22787.1 - 0.0056 17.0 0.1 0.05 13.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain SWI2_SNF2 PF18766.1 KOO22787.1 - 0.038 13.7 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 SWI2/SNF2 ATPase DUF2457 PF10446.9 KOO22788.1 - 7 5.7 14.2 13 4.8 14.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) cNMP_binding PF00027.29 KOO22789.1 - 1.2e-05 25.2 0.1 0.0025 17.8 0.1 2.6 2 1 1 3 3 3 2 Cyclic nucleotide-binding domain DUF365 PF04033.12 KOO22789.1 - 0.1 12.9 0.2 0.32 11.3 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF365) DUF4609 PF15382.6 KOO22789.1 - 0.13 12.2 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) Peptidase_C69 PF03577.15 KOO22791.1 - 2.1e-52 178.4 0.1 3.1e-51 174.5 0.1 2.5 1 1 0 1 1 1 1 Peptidase family C69 BING4CT PF08149.11 KOO22791.1 - 1e-35 121.4 0.0 1.6e-33 114.3 0.0 2.5 2 0 0 2 2 2 2 BING4CT (NUC141) domain WD40 PF00400.32 KOO22791.1 - 6.6e-05 23.6 2.4 0.0013 19.6 0.0 3.8 4 1 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO22791.1 - 0.0016 18.7 0.0 1.7 9.0 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain APG6_N PF17675.1 KOO22792.1 - 0.0045 17.5 28.8 0.0086 16.6 14.9 2.6 1 1 1 2 2 2 2 Apg6 coiled-coil region RasGAP_C PF03836.15 KOO22792.1 - 0.083 13.0 2.2 0.25 11.5 1.9 1.9 1 1 1 2 2 2 0 RasGAP C-terminus Suppressor_APC PF11414.8 KOO22792.1 - 0.13 12.3 0.4 0.13 12.3 0.4 2.5 2 2 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein ERM PF00769.19 KOO22792.1 - 0.24 11.2 25.9 1.3 8.8 9.9 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family HIP1_clath_bdg PF16515.5 KOO22792.1 - 2.1 9.0 19.6 0.19 12.4 6.5 2.7 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3679 PF12438.8 KOO22793.1 - 4 7.2 8.2 9.9 5.9 8.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3679) HC2 PF07382.11 KOO22793.1 - 8 6.5 62.0 0.028 14.5 52.3 1.9 2 0 0 2 2 2 0 Histone H1-like nucleoprotein HC2 SHIPPO-rpt PF07004.12 KOO22795.1 - 0.0002 22.1 34.7 0.096 13.6 0.1 6.9 7 1 0 7 7 7 4 Sperm-tail PG-rich repeat DUF229 PF02995.17 KOO22796.1 - 5.8e-10 38.4 0.0 8e-10 37.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Exotox-A_target PF09102.10 KOO22797.1 - 0.054 13.5 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Exotoxin A, targeting Pyr_redox_2 PF07992.14 KOO22798.1 - 2.9e-38 131.8 0.0 3.6e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO22798.1 - 4.1e-10 40.1 0.0 1.3e-09 38.5 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase WD40 PF00400.32 KOO22799.1 - 1.7e-18 66.6 17.8 7.8e-07 29.7 0.1 9.2 10 0 0 10 10 10 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO22799.1 - 3.3e-11 43.3 0.2 0.062 13.6 0.1 6.3 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 KOO22799.1 - 0.00024 21.0 0.4 0.018 14.9 0.2 2.5 1 1 1 2 2 2 1 Region in Clathrin and VPS Coatomer_WDAD PF04053.14 KOO22799.1 - 0.011 14.8 0.7 4.3 6.3 0.0 4.0 4 2 1 5 5 5 0 Coatomer WD associated region TPR_19 PF14559.6 KOO22799.1 - 0.046 14.2 7.3 1.8 9.2 0.2 4.3 2 2 2 4 4 4 0 Tetratricopeptide repeat Ge1_WD40 PF16529.5 KOO22799.1 - 0.065 12.2 0.1 17 4.2 0.0 3.5 3 1 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KOO22799.1 - 0.11 11.8 0.0 2.9 7.1 0.0 2.9 4 0 0 4 4 4 0 WD40-like domain Me-amine-dh_H PF06433.11 KOO22799.1 - 0.11 11.3 0.0 0.22 10.4 0.0 1.4 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) Mito_carr PF00153.27 KOO22801.1 - 2.5e-39 133.1 2.4 5.5e-19 67.9 0.2 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF1072 PF06380.11 KOO22801.1 - 3.3 7.6 5.5 0.61 10.0 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) SNF2_N PF00176.23 KOO22805.1 - 4.5e-62 209.8 0.0 7.4e-62 209.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO22805.1 - 2.4e-18 66.5 0.7 9.6e-18 64.6 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO22805.1 - 1.1e-07 32.1 0.0 2.7e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO22805.1 - 0.0035 17.1 0.0 0.0063 16.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSM_b PF10741.9 KOO22805.1 - 0.0072 16.1 0.1 0.044 13.6 0.1 2.2 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein M subtype b HDA2-3 PF11496.8 KOO22805.1 - 0.14 11.3 0.0 0.74 8.9 0.0 2.1 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 Pkinase_Tyr PF07714.17 KOO22806.1 - 2.7e-24 85.9 0.0 4.9e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO22806.1 - 2e-22 79.8 0.0 4.3e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain PDZ_6 PF17820.1 KOO22806.1 - 0.023 14.5 0.0 0.071 13.0 0.0 1.8 1 0 0 1 1 1 0 PDZ domain HTH_28 PF13518.6 KOO22807.1 - 0.062 13.4 2.6 4.1 7.6 0.1 3.8 2 1 0 2 2 2 0 Helix-turn-helix domain DUF4576 PF15144.6 KOO22808.1 - 0.33 10.8 4.1 0.6 10.0 4.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) Methyltransf_11 PF08241.12 KOO22809.1 - 1.3e-14 54.6 0.2 3.3e-14 53.3 0.2 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22809.1 - 4.9e-13 49.6 0.2 1.3e-12 48.2 0.2 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO22809.1 - 4.7e-12 46.5 0.8 1.5e-11 44.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO22809.1 - 9.7e-12 45.0 0.0 1.5e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO22809.1 - 7.3e-11 42.1 0.0 1.4e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 KOO22809.1 - 0.0001 22.0 0.0 0.00025 20.7 0.0 1.5 1 0 0 1 1 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 KOO22809.1 - 0.0088 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family HMG_CoA_synt_N PF01154.17 KOO22813.1 - 1.9e-45 154.9 0.0 3.1e-45 154.1 0.0 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 KOO22813.1 - 1.8e-31 109.8 0.0 3.3e-29 102.4 0.0 2.2 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal WD40 PF00400.32 KOO22814.1 - 7e-13 48.8 6.6 8.5e-05 23.3 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO22814.1 - 9.8e-06 25.8 0.2 0.0007 19.8 0.1 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO22814.1 - 7.7e-05 21.8 0.6 0.00032 19.8 0.6 1.9 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein HEAT PF02985.22 KOO22815.1 - 1.6e-37 124.3 33.6 0.00029 20.9 0.1 13.0 14 0 0 14 14 13 9 HEAT repeat HEAT_2 PF13646.6 KOO22815.1 - 3.6e-24 84.9 20.9 4e-06 27.1 0.0 7.1 2 1 6 8 8 8 7 HEAT repeats TB2_DP1_HVA22 PF03134.19 KOO22815.1 - 1.8e-15 56.6 3.1 3.8e-15 55.6 3.1 1.6 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Vac14_Fab1_bd PF12755.7 KOO22815.1 - 3.3e-09 37.2 0.3 0.079 13.6 0.0 6.8 4 3 3 7 7 7 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 KOO22815.1 - 1.4e-07 31.8 20.5 0.16 12.5 0.7 8.0 7 2 2 9 9 7 4 HEAT-like repeat Cnd1 PF12717.7 KOO22815.1 - 8.9e-05 22.6 6.9 0.26 11.3 0.0 5.4 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 KOO22815.1 - 0.0036 17.5 5.6 16 5.7 0.0 5.0 6 1 0 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 KOO22815.1 - 0.0073 14.9 8.0 2.1 6.8 0.1 3.8 3 1 0 3 3 3 3 Adaptin N terminal region Arm PF00514.23 KOO22815.1 - 0.018 15.0 4.8 2.1 8.5 0.0 4.7 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat MMS19_N PF14500.6 KOO22815.1 - 0.061 12.9 0.3 21 4.6 0.0 3.4 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II DRIM PF07539.12 KOO22815.1 - 0.12 10.7 5.7 1.1 7.5 3.7 2.8 1 1 1 2 2 2 0 Down-regulated in metastasis Dus PF01207.17 KOO22816.1 - 1.5e-22 80.1 0.1 3e-22 79.1 0.1 1.5 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF1619 PF07773.11 KOO22817.1 - 1.5e-07 31.7 0.0 2.3e-06 27.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1619) TetR_C_7 PF14246.6 KOO22818.1 - 0.013 15.5 0.7 1.5 8.8 0.0 2.4 1 1 1 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain SHIPPO-rpt PF07004.12 KOO22819.1 - 8e-06 26.5 23.2 1.2 10.1 0.1 6.9 6 1 0 6 6 6 5 Sperm-tail PG-rich repeat Bestrophin PF01062.21 KOO22821.1 - 1.6e-14 54.0 0.8 2.4e-14 53.5 0.8 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Beta-lactamase PF00144.24 KOO22822.1 - 7.5e-14 51.7 0.2 8e-13 48.3 0.0 2.7 2 1 0 2 2 2 1 Beta-lactamase Helicase_C_2 PF13307.6 KOO22823.1 - 2e-50 171.3 0.0 3e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 KOO22823.1 - 1.5e-33 115.9 0.2 2.2e-33 115.3 0.2 1.3 1 0 0 1 1 1 1 DEAD_2 DUF2735 PF10931.8 KOO22823.1 - 0.011 16.3 0.1 0.034 14.8 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2735) HBB PF06777.11 KOO22823.1 - 0.045 13.4 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Helical and beta-bridge domain tRNA_edit PF04073.15 KOO22824.1 - 0.0053 16.8 1.0 40 4.3 0.0 5.9 5 2 2 7 7 7 1 Aminoacyl-tRNA editing domain SH3_7 PF12914.7 KOO22824.1 - 0.023 14.9 0.0 4.4 7.6 0.0 2.7 2 0 0 2 2 2 0 SH3 domain of SH3b2 type FKBP_C PF00254.28 KOO22825.1 - 2.4e-28 98.3 0.0 1.4e-11 44.5 0.0 3.4 3 0 0 3 3 3 3 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 KOO22825.1 - 0.0041 17.1 6.0 0.32 11.2 0.7 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO22825.1 - 0.0082 15.9 6.9 2.2 8.2 0.5 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO22825.1 - 0.11 12.7 2.1 15 6.1 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4502 PF14950.6 KOO22825.1 - 8.6 5.7 8.6 34 3.7 6.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4502) LRR_6 PF13516.6 KOO22826.1 - 4.7e-66 213.3 17.4 0.00022 21.0 0.0 12.4 12 0 0 12 12 12 12 Leucine Rich repeat EIF_2_alpha PF07541.12 KOO22826.1 - 2.5e-08 34.0 6.5 0.4 10.8 0.1 5.9 1 1 2 4 4 4 3 Eukaryotic translation initiation factor 2 alpha subunit LRR_4 PF12799.7 KOO22826.1 - 0.0014 19.0 2.8 91 3.7 0.0 6.4 4 2 3 7 7 7 0 Leucine Rich repeats (2 copies) CbiG_N PF11760.8 KOO22826.1 - 0.0026 17.7 34.4 4 7.5 0.1 10.0 9 2 1 10 10 10 2 Cobalamin synthesis G N-terminal SpoU_sub_bind PF08032.12 KOO22826.1 - 0.004 17.4 4.6 9.1 6.6 0.1 5.0 3 1 3 6 6 6 1 RNA 2'-O ribose methyltransferase substrate binding HOASN PF14515.6 KOO22826.1 - 0.25 11.8 26.1 46 4.5 0.7 8.5 1 1 7 9 9 9 0 Haem-oxygenase-associated N-terminal helices Peptidase_M16_M PF16187.5 KOO22827.1 - 9.8e-45 153.0 0.0 6e-28 97.9 0.0 2.2 2 0 0 2 2 2 2 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 KOO22827.1 - 1.4e-14 54.5 0.0 7e-07 29.4 0.0 3.6 2 1 1 3 3 3 3 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOO22827.1 - 4.5e-14 52.7 0.0 1.4e-13 51.1 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) AMP-binding PF00501.28 KOO22828.1 - 6.4e-43 146.9 0.0 7.4e-42 143.4 0.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme GH3 PF03321.13 KOO22828.1 - 0.21 10.4 0.0 0.89 8.3 0.0 1.8 2 0 0 2 2 2 0 GH3 auxin-responsive promoter PAE PF03283.13 KOO22829.1 - 0.098 11.8 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Pectinacetylesterase Abhydrolase_6 PF12697.7 KOO22829.1 - 0.16 12.5 6.8 0.22 12.1 6.8 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Ion_trans PF00520.31 KOO22830.1 - 6.9e-21 74.6 9.8 8.6e-21 74.3 9.8 1.1 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 KOO22830.1 - 4.8e-09 36.2 0.0 4.2e-08 33.2 0.0 2.3 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KOO22830.1 - 2.6e-07 30.5 2.8 2.6e-07 30.5 2.8 2.2 2 0 0 2 2 2 1 Ion channel FA_hydroxylase PF04116.13 KOO22831.1 - 2.1e-13 50.8 12.4 3.7e-13 50.0 12.4 1.4 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily ATPase_gene1 PF09527.10 KOO22831.1 - 0.0067 16.6 0.8 0.022 14.9 0.8 1.9 1 0 0 1 1 1 1 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Esterase_phd PF10503.9 KOO22832.1 - 2e-09 37.3 0.3 3.3e-09 36.6 0.3 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase Esterase PF00756.20 KOO22832.1 - 2.2e-06 27.5 0.0 3.5e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 KOO22832.1 - 6.9e-06 26.8 1.3 1e-05 26.3 1.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 KOO22832.1 - 4.2e-05 23.3 0.1 0.00025 20.7 0.1 2.1 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 KOO22832.1 - 9.9e-05 22.2 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 KOO22832.1 - 0.00023 20.9 0.1 0.00032 20.4 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOO22832.1 - 0.00045 19.8 0.0 0.00096 18.7 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2048 PF09752.9 KOO22832.1 - 0.045 12.9 0.0 0.078 12.1 0.0 1.3 1 0 0 1 1 1 0 Abhydrolase domain containing 18 AXE1 PF05448.12 KOO22832.1 - 0.048 12.3 0.0 0.09 11.4 0.0 1.4 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Lipase_3 PF01764.25 KOO22832.1 - 0.16 11.8 0.0 0.61 10.0 0.0 1.8 2 0 0 2 2 2 0 Lipase (class 3) CBM_48 PF02922.18 KOO22832.1 - 0.18 12.2 0.1 3.5 8.0 0.0 2.4 2 0 0 2 2 2 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) DUF2974 PF11187.8 KOO22832.1 - 0.18 11.3 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) 2OG-FeII_Oxy_3 PF13640.6 KOO22833.1 - 4.7e-06 27.4 0.0 7.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Kinesin PF00225.23 KOO22834.1 - 5.5e-80 268.8 0.0 8.9e-80 268.1 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO22834.1 - 4.4e-24 85.1 0.0 1.1e-23 83.9 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding IQ PF00612.27 KOO22834.1 - 0.00028 20.4 0.0 0.00092 18.8 0.0 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF737 PF05300.11 KOO22834.1 - 0.00094 19.6 8.3 0.00094 19.6 8.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF737) DUF677 PF05055.12 KOO22834.1 - 0.029 13.3 4.2 0.049 12.5 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF677) TSC22 PF01166.18 KOO22834.1 - 0.039 14.3 6.0 0.066 13.5 1.9 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family Atg14 PF10186.9 KOO22834.1 - 0.066 12.3 11.2 0.12 11.5 11.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ResIII PF04851.15 KOO22834.1 - 0.094 12.7 0.9 4 7.4 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Macoilin PF09726.9 KOO22834.1 - 0.2 10.1 11.3 0.31 9.5 11.3 1.3 1 0 0 1 1 1 0 Macoilin family TPR_MLP1_2 PF07926.12 KOO22834.1 - 3.1 7.9 24.7 8 6.5 24.4 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Hamartin PF04388.12 KOO22835.1 - 0.16 10.6 11.4 0.25 10.0 11.4 1.3 1 0 0 1 1 1 0 Hamartin protein UbiA PF01040.18 KOO22836.1 - 2.2e-17 63.2 1.8 2.2e-10 40.3 0.1 3.0 1 1 2 3 3 3 3 UbiA prenyltransferase family Bac_rhodopsin PF01036.18 KOO22837.1 - 4.7e-25 88.5 8.1 5.9e-25 88.2 8.1 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Cpn60_TCP1 PF00118.24 KOO22839.1 - 4.2e-154 513.8 4.5 4.7e-154 513.6 4.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DnaJ PF00226.31 KOO22840.1 - 7.9e-20 70.8 0.0 1.3e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Ank_2 PF12796.7 KOO22840.1 - 2.8e-17 63.1 14.2 3.3e-09 37.2 2.3 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO22840.1 - 2e-11 44.2 5.5 3.9e-08 33.7 0.5 4.4 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO22840.1 - 7e-08 32.6 10.7 0.012 16.0 1.5 5.5 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22840.1 - 1.2e-06 28.4 3.6 12 6.8 0.1 5.7 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 KOO22840.1 - 2.1e-06 27.9 13.0 0.18 12.3 0.2 5.6 5 0 0 5 5 5 3 Ankyrin repeat Helicase_C PF00271.31 KOO22841.1 - 9.2e-13 48.5 0.0 1.8e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO22841.1 - 0.00029 20.6 0.0 0.00048 19.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase CKS PF01111.19 KOO22843.1 - 1.4e-36 124.6 0.1 1.6e-36 124.4 0.1 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit UPF0564 PF10595.9 KOO22844.1 - 3.2e-20 72.5 55.0 3.2e-20 72.5 55.0 2.2 2 1 0 2 2 2 1 Uncharacterised protein family UPF0564 HYLS1_C PF15311.6 KOO22845.1 - 3e-09 37.5 7.3 0.00015 22.4 0.9 3.3 3 1 0 3 3 3 2 Hydrolethalus syndrome protein 1 C-terminus Hydrolase_4 PF12146.8 KOO22846.1 - 9.9e-08 31.5 0.2 0.00014 21.2 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO22846.1 - 3.1e-05 23.8 0.2 0.0091 15.7 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOO22846.1 - 0.00077 20.1 0.6 0.001 19.7 0.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF818 PF05677.12 KOO22846.1 - 0.0084 15.1 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.21 KOO22846.1 - 0.011 15.2 0.1 0.22 11.0 0.1 2.1 1 1 0 1 1 1 0 Prolyl oligopeptidase family UPF0227 PF05728.12 KOO22846.1 - 0.044 13.7 0.0 3.3 7.6 0.0 2.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) Citrate_bind PF16114.5 KOO22846.1 - 0.056 12.9 0.0 0.079 12.5 0.0 1.2 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding EF-hand_1 PF00036.32 KOO22847.1 - 4.2e-11 41.6 0.0 6e-06 25.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO22847.1 - 2.7e-10 39.3 0.0 2.6e-05 23.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO22847.1 - 1.1e-08 34.2 0.0 3.8e-05 23.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO22847.1 - 2e-07 31.3 0.0 0.027 14.9 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair DUF16 PF01519.16 KOO22847.1 - 0.00015 22.2 0.1 0.00027 21.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF16 Snapin_Pallidin PF14712.6 KOO22847.1 - 0.0004 20.7 0.7 0.0011 19.4 0.5 1.7 2 0 0 2 2 2 1 Snapin/Pallidin Syntaxin PF00804.25 KOO22847.1 - 0.00069 19.3 1.4 0.0011 18.6 1.4 1.3 1 0 0 1 1 1 1 Syntaxin EF-hand_8 PF13833.6 KOO22847.1 - 0.00083 19.2 0.0 0.0024 17.7 0.0 1.8 2 0 0 2 2 1 1 EF-hand domain pair Dockerin_1 PF00404.18 KOO22847.1 - 0.0034 17.5 0.2 0.018 15.2 0.3 2.0 1 1 1 2 2 2 1 Dockerin type I domain TMF_DNA_bd PF12329.8 KOO22847.1 - 0.0085 16.1 6.6 0.02 14.9 1.2 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 DNA binding EzrA PF06160.12 KOO22847.1 - 0.01 14.1 1.0 0.014 13.6 1.0 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Atg14 PF10186.9 KOO22847.1 - 0.014 14.5 0.3 0.019 14.1 0.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 KOO22847.1 - 0.014 14.3 1.1 0.021 13.7 1.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF812 PF05667.11 KOO22847.1 - 0.014 14.3 1.0 0.017 14.0 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) SlyX PF04102.12 KOO22847.1 - 0.019 15.5 1.0 0.062 13.9 1.0 1.9 1 1 0 1 1 1 0 SlyX Mod_r PF07200.13 KOO22847.1 - 0.022 14.9 0.2 0.044 13.9 0.2 1.4 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein BLOC1_2 PF10046.9 KOO22847.1 - 0.031 14.6 0.7 0.066 13.5 0.7 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Seryl_tRNA_N PF02403.22 KOO22847.1 - 0.039 14.2 3.1 0.075 13.3 3.1 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain KxDL PF10241.9 KOO22847.1 - 0.042 14.1 0.6 0.17 12.2 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF1664 PF07889.12 KOO22847.1 - 0.058 13.4 0.3 0.098 12.7 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Phage_Nu1 PF07471.12 KOO22847.1 - 0.06 13.1 0.2 0.14 11.9 0.2 1.6 1 1 0 1 1 1 0 Phage DNA packaging protein Nu1 SPARC_Ca_bdg PF10591.9 KOO22847.1 - 0.066 13.5 0.1 0.18 12.1 0.0 1.8 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region AAA_23 PF13476.6 KOO22847.1 - 0.07 13.6 0.8 0.091 13.3 0.8 1.2 1 0 0 1 1 1 0 AAA domain Matrilin_ccoil PF10393.9 KOO22847.1 - 0.077 12.9 2.8 0.21 11.5 0.1 2.6 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF533 PF04391.12 KOO22847.1 - 0.12 12.0 2.0 1.6 8.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF533) ZapB PF06005.12 KOO22847.1 - 0.12 12.8 1.9 0.25 11.8 1.9 1.5 1 0 0 1 1 1 0 Cell division protein ZapB Med21 PF11221.8 KOO22847.1 - 0.26 11.5 2.6 0.28 11.4 1.2 1.8 2 1 0 2 2 1 0 Subunit 21 of Mediator complex Methyltr_RsmB-F PF01189.17 KOO22848.1 - 3.6e-39 134.5 0.0 4.6e-39 134.1 0.0 1.1 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KOO22848.1 - 2.1e-07 31.3 0.0 3.6e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase NusB PF01029.18 KOO22848.1 - 1.3e-05 25.4 0.0 2.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 NusB family Methyltransf_31 PF13847.6 KOO22848.1 - 0.0063 16.3 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22848.1 - 0.016 15.9 0.1 0.055 14.2 0.1 1.9 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 KOO22848.1 - 0.016 15.0 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmF_N PF17125.5 KOO22848.1 - 0.032 14.7 0.0 0.12 12.9 0.0 1.9 2 0 0 2 2 2 0 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltransf_15 PF09445.10 KOO22848.1 - 0.087 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DUF616 PF04765.13 KOO22850.1 - 2.3e-36 125.7 0.0 8.1e-36 123.9 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF616) EF-hand_7 PF13499.6 KOO22851.1 - 1.1e-09 38.7 0.0 3.4e-09 37.0 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO22851.1 - 3.4e-09 35.9 0.0 6.3e-05 22.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO22851.1 - 1.7e-07 30.3 0.0 0.00036 19.9 0.0 2.7 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 KOO22851.1 - 2.8e-05 24.4 0.0 5.7e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KOO22851.1 - 3.4e-05 23.6 0.0 0.0034 17.2 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO22851.1 - 0.0088 15.5 0.0 2.4 7.8 0.0 3.0 3 0 0 3 3 3 1 EF hand HTH_21 PF13276.6 KOO22851.1 - 0.017 15.3 0.1 0.16 12.1 0.0 2.6 2 0 0 2 2 2 0 HTH-like domain EF-hand_10 PF14788.6 KOO22851.1 - 0.067 13.1 0.0 0.17 11.7 0.0 1.7 1 1 0 1 1 1 0 EF hand Glyco_transf_88 PF16849.5 KOO22851.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 88 GSHPx PF00255.19 KOO22852.1 - 4.1e-23 81.0 0.0 5.5e-23 80.6 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin PF00085.20 KOO22853.1 - 3.6e-17 62.2 0.0 4.4e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KOO22853.1 - 0.00084 18.8 0.0 0.00094 18.6 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KOO22853.1 - 0.0032 17.9 0.0 0.008 16.6 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOO22853.1 - 0.02 15.2 0.0 0.064 13.6 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_4 PF13462.6 KOO22853.1 - 0.042 14.0 0.0 0.064 13.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin AhpC-TSA PF00578.21 KOO22853.1 - 0.051 13.5 0.0 0.06 13.3 0.0 1.1 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_7 PF13899.6 KOO22853.1 - 0.06 13.5 0.1 0.2 11.8 0.1 1.9 1 1 1 2 2 2 0 Thioredoxin-like Hydrolase_4 PF12146.8 KOO22856.1 - 3.1e-15 56.1 0.0 6.9e-07 28.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOO22856.1 - 1.8e-12 47.2 0.0 2.6e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 KOO22856.1 - 4.9e-07 30.6 2.8 0.0001 23.0 2.8 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO22856.1 - 4.2e-06 26.6 0.1 0.0019 17.9 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 KOO22856.1 - 0.0025 17.6 0.0 0.48 10.2 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase BAAT_C PF08840.11 KOO22856.1 - 0.004 17.1 0.0 1.3 8.9 0.0 2.2 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal LIP PF03583.14 KOO22856.1 - 0.016 14.6 0.4 0.1 11.9 0.4 1.9 2 0 0 2 2 2 0 Secretory lipase Abhydrolase_3 PF07859.13 KOO22856.1 - 0.047 13.5 0.1 0.086 12.7 0.1 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Asp2 PF16929.5 KOO22856.1 - 0.087 11.8 0.1 0.13 11.2 0.1 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter FSH1 PF03959.13 KOO22856.1 - 0.088 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF818 PF05677.12 KOO22856.1 - 0.1 11.6 0.1 0.15 11.0 0.1 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Peptidase_S15 PF02129.18 KOO22856.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 KOO22856.1 - 0.11 12.0 0.0 0.37 10.3 0.0 1.8 1 1 0 1 1 1 0 Dienelactone hydrolase family DUF3089 PF11288.8 KOO22856.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) EF-hand_7 PF13499.6 KOO22857.1 - 1.5e-09 38.1 2.0 2.9e-09 37.3 2.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO22857.1 - 8e-08 31.6 0.5 0.00016 21.3 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO22857.1 - 2.3e-07 29.9 2.0 0.0035 16.8 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO22857.1 - 4e-05 23.4 0.2 0.0001 22.1 0.1 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO22857.1 - 4.3e-05 22.8 0.3 0.0039 16.6 0.0 2.6 2 0 0 2 2 2 1 EF hand Sigma54_CBD PF04963.13 KOO22857.1 - 0.012 15.4 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain DDRGK PF09756.9 KOO22857.1 - 0.015 14.9 3.3 0.022 14.3 3.3 1.2 1 0 0 1 1 1 0 DDRGK domain EF-hand_11 PF08976.11 KOO22857.1 - 0.016 16.0 0.0 0.026 15.4 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain EF-hand_6 PF13405.6 KOO22859.1 - 0.00059 19.6 0.1 0.091 12.7 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO22859.1 - 0.022 14.3 0.0 9.2 6.1 0.0 2.7 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 KOO22859.1 - 0.29 11.6 2.6 5.4 7.5 0.1 3.3 1 1 1 2 2 2 0 EF-hand domain pair DEAD PF00270.29 KOO22860.1 - 4.9e-39 133.9 0.0 9.8e-39 132.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO22860.1 - 6.5e-24 84.4 0.0 1.2e-23 83.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KOO22860.1 - 0.077 12.2 0.8 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase DUF4838 PF16126.5 KOO22862.1 - 1.1e-81 274.1 0.6 2e-81 273.3 0.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4838) PKD_channel PF08016.12 KOO22863.1 - 2.8e-27 95.5 15.4 1.6e-24 86.4 18.6 2.3 2 0 0 2 2 2 2 Polycystin cation channel Roc PF08477.13 KOO22864.1 - 0.0006 20.0 0.0 0.0052 17.0 0.0 2.3 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase DLIC PF05783.11 KOO22864.1 - 0.0025 16.7 0.4 0.12 11.2 0.0 2.2 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) IIGP PF05049.13 KOO22864.1 - 0.016 14.3 0.1 0.09 11.8 0.0 1.9 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) MCM PF00493.23 KOO22864.1 - 0.15 11.1 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain Mcm10 PF09332.11 KOO22865.1 - 5.1e-26 91.9 4.5 8.2e-26 91.3 4.5 1.3 1 0 0 1 1 1 1 Mcm10 replication factor zf-primase PF09329.11 KOO22865.1 - 4.1e-16 58.5 0.8 9.3e-16 57.4 0.8 1.6 1 0 0 1 1 1 1 Primase zinc finger MafB19-deam PF14437.6 KOO22865.1 - 0.094 12.5 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 MafB19-like deaminase Zn-ribbon_8 PF09723.10 KOO22865.1 - 6.2 7.0 9.3 3 8.0 1.2 2.8 2 0 0 2 2 2 0 Zinc ribbon domain GRASP55_65 PF04495.14 KOO22866.1 - 1.2e-44 152.0 0.0 2.9e-27 95.7 0.0 2.0 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 KOO22866.1 - 1.6e-07 31.0 0.0 0.0017 18.2 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KOO22866.1 - 2e-07 31.2 0.1 0.0017 18.7 0.0 2.2 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 KOO22866.1 - 0.00095 19.5 0.1 1.9 8.9 0.0 2.2 2 0 0 2 2 2 2 PDZ domain CofC PF01983.16 KOO22866.1 - 0.059 12.5 0.0 6.5 5.9 0.0 2.4 2 1 1 3 3 3 0 Guanylyl transferase CofC like tRNA-synt_2 PF00152.20 KOO22867.1 - 2.8e-76 256.6 0.0 3.6e-76 256.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOO22867.1 - 1.6e-07 31.2 0.0 2.6e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOO22867.1 - 0.0052 16.3 0.2 0.38 10.2 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) UCH PF00443.29 KOO22868.1 - 1.9e-41 142.3 0.0 2.5e-41 141.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO22868.1 - 2.8e-23 83.0 0.0 8.6e-23 81.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Galactosyl_T PF01762.21 KOO22869.1 - 2.9e-06 27.2 0.0 8.7e-06 25.7 0.0 1.8 2 0 0 2 2 2 1 Galactosyltransferase Ldl_recept_b PF00058.17 KOO22870.1 - 8.8e-07 29.3 0.1 0.0024 18.3 0.0 3.7 3 1 0 3 3 3 2 Low-density lipoprotein receptor repeat class B Acylphosphatase PF00708.18 KOO22871.1 - 9.3e-09 35.6 0.0 0.00045 20.6 0.0 3.0 2 1 1 3 3 3 2 Acylphosphatase Tn7_Tnp_TnsA_C PF08721.11 KOO22872.1 - 0.065 13.9 0.2 0.19 12.4 0.2 1.8 1 1 0 1 1 1 0 TnsA endonuclease C terminal IQ PF00612.27 KOO22874.1 - 0.24 11.3 1.7 0.8 9.7 1.7 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif PspB PF06667.12 KOO22874.1 - 7.9 6.6 7.1 3.2 7.9 0.5 2.9 2 0 0 2 2 2 0 Phage shock protein B NIF PF03031.18 KOO22876.1 - 0.059 13.1 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase PI3_PI4_kinase PF00454.27 KOO22877.1 - 1.6e-29 103.5 0.0 8.7e-22 78.1 0.0 2.2 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 KOO22877.1 - 0.054 12.8 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) PI3Ka PF00613.20 KOO22877.1 - 0.08 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) tRNA-synt_1b PF00579.25 KOO22878.1 - 3.8e-48 164.3 0.0 1.1e-42 146.4 0.0 3.1 3 0 0 3 3 3 3 tRNA synthetases class I (W and Y) 2OG-FeII_Oxy_3 PF13640.6 KOO22879.1 - 4.7e-15 56.3 0.2 8.2e-15 55.5 0.2 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO22879.1 - 3.4e-07 30.7 10.6 3.4e-07 30.7 10.6 3.0 2 1 0 2 2 2 1 ShK domain-like CCDC53 PF10152.9 KOO22880.1 - 0.0074 16.7 0.0 0.35 11.3 0.0 2.5 2 1 0 2 2 2 2 Subunit CCDC53 of WASH complex Sec23_trunk PF04811.15 KOO22881.1 - 2.6e-41 141.8 0.0 4.5e-41 141.0 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KOO22881.1 - 3.5e-24 84.6 0.6 6.3e-24 83.8 0.6 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KOO22881.1 - 2.4e-17 63.4 0.0 5.3e-17 62.4 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KOO22881.1 - 5.7e-16 58.3 3.0 1.3e-15 57.1 3.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KOO22881.1 - 2.1e-07 30.8 0.0 4.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat ACT_6 PF13740.6 KOO22882.1 - 2.4e-07 30.6 0.0 2.4e-06 27.4 0.0 2.2 2 0 0 2 2 2 1 ACT domain ACT_4 PF13291.6 KOO22882.1 - 0.00026 21.5 0.0 0.83 10.3 0.0 2.2 2 0 0 2 2 2 2 ACT domain Exo_endo_phos PF03372.23 KOO22884.1 - 4.1e-14 52.6 1.5 7.4e-14 51.8 1.5 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SAP PF02037.27 KOO22884.1 - 1.9e-08 33.9 0.1 9e-08 31.7 0.1 2.1 2 0 0 2 2 2 1 SAP domain GTP_EFTU PF00009.27 KOO22886.1 - 5.6e-34 117.4 0.1 4e-33 114.6 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KOO22886.1 - 1.3e-17 63.9 2.0 1.6e-17 63.5 0.2 2.2 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 KOO22886.1 - 1.7e-10 41.2 5.2 4.4e-08 33.4 0.1 3.2 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOO22886.1 - 1.4e-07 31.6 0.4 1.5e-06 28.3 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 KOO22886.1 - 0.00012 21.9 2.4 0.00045 20.1 2.4 2.0 1 1 0 1 1 1 1 Elongation factor Tu domain 4 Roc PF08477.13 KOO22886.1 - 0.00055 20.1 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 KOO22886.1 - 0.0081 16.0 0.0 0.048 13.4 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 KOO22886.1 - 0.012 15.5 0.6 8.8 6.2 0.1 3.3 1 1 1 2 2 2 0 RsgA GTPase Ras PF00071.22 KOO22886.1 - 0.018 14.6 0.0 0.15 11.6 0.0 2.4 2 1 0 2 2 2 0 Ras family AAA_22 PF13401.6 KOO22886.1 - 0.071 13.4 0.8 0.76 10.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain DHHA2 PF02833.14 KOO22886.1 - 0.092 12.9 0.2 0.25 11.5 0.2 1.7 1 0 0 1 1 1 0 DHHA2 domain DUF3969 PF13108.6 KOO22886.1 - 0.12 12.4 0.1 0.27 11.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3969) SURF4 PF02077.15 KOO22887.1 - 2.3e-19 70.0 10.4 1.5e-09 37.8 0.5 3.3 3 1 0 3 3 3 3 SURF4 family DoxX PF07681.12 KOO22887.1 - 0.0085 16.7 20.9 0.014 16.0 5.0 3.5 2 1 1 3 3 3 2 DoxX CDP-OH_P_transf PF01066.21 KOO22887.1 - 0.22 12.3 4.6 2.1 9.1 1.3 3.0 2 1 0 2 2 2 0 CDP-alcohol phosphatidyltransferase Exo_endo_phos PF03372.23 KOO22888.1 - 8e-25 87.7 0.1 1.1e-24 87.3 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C6H2 PF15801.5 KOO22888.1 - 0.0032 17.7 0.1 0.0051 17.1 0.1 1.4 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding Fasciclin PF02469.22 KOO22889.1 - 8e-72 239.5 0.1 1.5e-34 119.0 0.0 2.1 2 0 0 2 2 2 2 Fasciclin domain DUF211 PF02680.14 KOO22889.1 - 0.1 12.8 9.4 1.8 8.7 0.7 2.5 2 0 0 2 2 2 0 Uncharacterized ArCR, COG1888 DUF5495 PF17599.2 KOO22889.1 - 0.11 12.8 0.0 16 5.9 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5495) Cloacin_immun PF03513.14 KOO22889.1 - 0.19 12.1 0.1 10 6.5 0.0 2.3 2 0 0 2 2 2 0 Cloacin immunity protein BRCT_3 PF18428.1 KOO22889.1 - 0.45 10.6 1.9 11 6.2 0.1 2.4 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Nucleotid_trans PF03407.16 KOO22890.1 - 3.6e-32 112.1 0.0 5.4e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase TagF_N PF09867.9 KOO22890.1 - 0.023 14.7 0.6 0.05 13.6 0.6 1.5 1 0 0 1 1 1 0 TagF N-terminal domain, Type VI secretion system-associated CtnDOT_TraJ PF07863.11 KOO22890.1 - 0.15 12.7 1.1 1.1 9.9 2.0 2.1 2 0 0 2 2 2 0 Homologues of TraJ from Bacteroides conjugative transposon FAM199X PF15814.5 KOO22890.1 - 3.7 6.5 7.2 6.5 5.7 7.2 1.3 1 0 0 1 1 1 0 Protein family FAM199X tRNA_bind PF01588.20 KOO22891.1 - 6.2e-11 42.3 0.0 1.2e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain SAM_2 PF07647.17 KOO22891.1 - 0.0056 16.8 0.0 2.6 8.2 0.0 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Mannosyl_trans3 PF11051.8 KOO22892.1 - 0.00042 19.8 0.0 0.00066 19.1 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.20 KOO22892.1 - 0.015 14.9 0.1 0.032 13.8 0.1 1.6 1 1 0 1 1 1 0 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 KOO22892.1 - 0.08 12.9 0.1 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Ribosomal_L11 PF00298.19 KOO22893.1 - 8e-26 90.3 0.0 1.2e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 KOO22893.1 - 1.8e-24 85.3 0.1 2.9e-24 84.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain RabGAP-TBC PF00566.18 KOO22894.1 - 2e-44 151.8 0.0 2.7e-44 151.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain UBA_4 PF14555.6 KOO22894.1 - 4.8e-08 32.7 0.6 1e-07 31.7 0.6 1.5 1 0 0 1 1 1 1 UBA-like domain WWE PF02825.20 KOO22894.1 - 2e-06 28.3 0.0 4.7e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 WWE domain TPR_1 PF00515.28 KOO22895.1 - 0.0063 16.3 1.4 1.1 9.2 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO22895.1 - 0.018 15.3 1.4 0.018 15.3 1.4 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO22895.1 - 0.27 11.7 12.2 0.38 11.3 1.5 3.8 2 1 1 3 3 3 0 Tetratricopeptide repeat Nop14 PF04147.12 KOO22895.1 - 0.77 7.9 13.9 0.96 7.6 13.9 1.1 1 0 0 1 1 1 0 Nop14-like family TPR_6 PF13174.6 KOO22895.1 - 0.87 10.4 3.9 37 5.3 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO22895.1 - 1.8 8.9 13.6 5.3 7.4 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat SDA1 PF05285.12 KOO22895.1 - 2.2 7.6 14.3 2.9 7.2 14.3 1.1 1 0 0 1 1 1 0 SDA1 Herpes_LMP1 PF05297.11 KOO22897.1 - 2.4 7.3 4.2 2.6 7.2 4.2 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) zf-UBR PF02207.20 KOO22898.1 - 1.9e-17 63.2 13.4 3.4e-17 62.4 13.4 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Glyco_transf_8 PF01501.20 KOO22899.1 - 1.3e-07 31.4 0.4 1.8e-06 27.7 0.4 2.6 1 1 0 1 1 1 1 Glycosyl transferase family 8 DUF647 PF04884.14 KOO22900.1 - 4.2e-52 177.2 0.6 5.7e-52 176.8 0.6 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis Mito_carr PF00153.27 KOO22901.1 - 1.2e-41 140.5 0.3 5.4e-16 58.3 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein ArgoL1 PF08699.10 KOO22901.1 - 0.066 12.9 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Argonaute linker 1 domain UQ_con PF00179.26 KOO22903.1 - 1.3e-23 83.2 0.0 2.1e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Anthrax_toxA PF03497.16 KOO22904.1 - 0.00042 20.5 0.0 0.00056 20.1 0.0 1.2 1 0 0 1 1 1 1 Anthrax toxin LF subunit cNMP_binding PF00027.29 KOO22905.1 - 7.2e-19 67.7 0.1 1.1e-18 67.1 0.1 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_1 PF00036.32 KOO22905.1 - 0.0002 20.7 1.3 0.00037 19.8 0.4 2.0 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO22905.1 - 0.00069 19.0 0.1 0.0023 17.4 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO22905.1 - 0.0033 17.8 0.3 0.015 15.8 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO22905.1 - 0.0038 17.0 0.7 0.012 15.4 0.7 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 KOO22905.1 - 0.0094 15.8 1.7 0.012 15.4 0.8 1.7 2 0 0 2 2 2 1 EF-hand domain pair Radical_SAM_C PF16199.5 KOO22907.1 - 3.4e-19 68.6 0.1 7.9e-19 67.5 0.1 1.7 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KOO22907.1 - 2.1e-15 57.5 0.0 5.7e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_10 PF13673.7 KOO22907.1 - 3.2e-06 27.1 0.1 6.9e-05 22.8 0.1 2.6 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO22907.1 - 3.6e-06 27.2 3.6 2.7e-05 24.4 2.2 2.8 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO22907.1 - 0.033 14.6 0.1 0.086 13.3 0.1 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Anoctamin PF04547.12 KOO22908.1 - 1.5e-88 297.7 6.5 1.3e-57 195.7 0.5 2.1 1 1 1 2 2 2 2 Calcium-activated chloride channel Anoct_dimer PF16178.5 KOO22908.1 - 0.00013 21.8 0.0 0.0074 16.0 0.0 2.2 1 1 1 2 2 2 2 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Ank_2 PF12796.7 KOO22909.1 - 2.9e-31 107.9 12.7 2.8e-09 37.4 0.2 4.1 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO22909.1 - 1.7e-27 95.1 10.8 6.5e-07 29.5 0.0 7.4 1 1 7 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22909.1 - 2.2e-13 49.1 10.0 0.84 10.4 0.1 7.6 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 KOO22909.1 - 4.3e-13 49.1 19.3 0.089 13.3 0.0 7.9 8 0 0 8 8 8 4 Ankyrin repeat Ank_4 PF13637.6 KOO22909.1 - 2.9e-11 43.6 6.8 0.0013 19.3 0.1 4.7 3 2 2 5 5 5 3 Ankyrin repeats (many copies) DUF3349 PF11829.8 KOO22909.1 - 4.4e-08 33.8 0.3 7.2 7.5 0.0 6.8 6 2 0 7 7 7 1 Protein of unknown function (DUF3349) DUF5047 PF16466.5 KOO22909.1 - 0.00012 22.4 20.7 0.66 10.3 0.1 6.7 1 1 6 7 7 7 3 Domain of unknown function (DUF5047) DUF2877 PF11392.8 KOO22909.1 - 0.00083 20.0 1.2 3.1 8.5 0.1 3.3 2 2 1 3 3 3 2 Protein of unknown function (DUF2877) DUF5492 PF17596.2 KOO22909.1 - 0.017 15.5 0.1 77 3.7 0.0 4.6 5 1 1 6 6 6 0 Family of unknown function (DUF5492) AMNp_N PF10423.9 KOO22909.1 - 0.085 12.5 0.0 6.2 6.4 0.0 3.3 2 1 3 5 5 5 0 Bacterial AMP nucleoside phosphorylase N-terminus DUF2976 PF11190.8 KOO22909.1 - 0.18 11.6 1.1 78 3.2 0.0 4.4 5 1 1 6 6 6 0 Protein of unknown function (DUF2976) Sulfotransfer_4 PF17784.1 KOO22909.1 - 0.97 9.2 12.2 4.4 7.1 2.4 4.6 2 1 1 4 4 4 0 Sulfotransferase domain HMG-CoA_red PF00368.18 KOO22910.1 - 3.6e-119 398.0 12.3 4e-117 391.3 12.3 2.0 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase SSI PF00720.17 KOO22910.1 - 0.043 13.8 2.1 0.44 10.5 0.2 3.0 2 1 1 3 3 3 0 Subtilisin inhibitor-like Ion_trans PF00520.31 KOO22911.1 - 2.5e-128 426.5 49.3 2.2e-39 135.2 3.7 5.0 4 1 0 4 4 4 4 Ion transport protein EF-hand_1 PF00036.32 KOO22911.1 - 6.4e-26 87.9 7.5 0.00012 21.3 0.1 6.6 7 0 0 7 7 7 5 EF hand EF-hand_7 PF13499.6 KOO22911.1 - 2.9e-23 82.1 11.7 9.1e-10 38.8 0.8 4.1 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO22911.1 - 2.5e-22 76.9 16.3 0.00012 21.7 0.2 7.4 8 0 0 8 8 6 5 EF-hand domain EF-hand_5 PF13202.6 KOO22911.1 - 2.5e-18 64.7 12.6 7e-05 22.1 0.1 5.1 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO22911.1 - 2.1e-10 40.3 11.1 1.6e-05 24.6 0.4 5.1 4 1 1 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO22911.1 - 7.5e-08 32.7 2.1 0.00041 20.6 0.1 3.3 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region PKD_channel PF08016.12 KOO22911.1 - 0.00061 18.6 7.2 0.00061 18.6 7.2 8.7 8 2 1 9 9 9 3 Polycystin cation channel GPHH PF16905.5 KOO22911.1 - 0.037 13.8 0.0 0.12 12.1 0.0 1.9 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_9 PF14658.6 KOO22911.1 - 0.058 13.7 0.4 0.93 9.9 0.1 2.9 3 0 0 3 3 3 0 EF-hand domain TM_helix PF05552.12 KOO22911.1 - 0.22 11.6 6.5 0.13 12.2 1.4 2.8 2 0 0 2 2 2 0 Conserved TM helix DUF3810 PF12725.7 KOO22911.1 - 0.46 9.8 3.2 4.4 6.5 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3810) Folliculin PF11704.8 KOO22911.1 - 4.9 7.0 5.4 0.46 10.3 0.3 1.9 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Pyr_redox_2 PF07992.14 KOO22912.1 - 2.5e-25 89.3 1.1 3.4e-25 88.9 1.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO22912.1 - 4.7e-08 33.5 1.2 0.00015 22.2 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO22912.1 - 2.4e-06 27.0 2.0 5.9e-05 22.5 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOO22912.1 - 0.00034 19.9 1.8 0.0016 17.7 0.1 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 KOO22912.1 - 0.00039 19.4 4.5 0.018 13.9 0.9 2.2 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 KOO22912.1 - 0.0024 18.1 1.0 0.68 10.2 0.3 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 KOO22912.1 - 0.0031 16.6 2.8 0.8 8.7 0.4 2.8 3 0 0 3 3 3 2 Lycopene cyclase protein NAD_binding_9 PF13454.6 KOO22912.1 - 0.0049 16.9 3.4 1.4 8.9 0.0 2.9 3 0 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 KOO22912.1 - 0.0087 15.7 7.0 0.92 9.0 3.2 2.7 2 1 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 KOO22912.1 - 4 6.6 6.2 4.3 6.5 1.6 2.3 2 0 0 2 2 2 0 FAD binding domain Methyltransf_25 PF13649.6 KOO22913.1 - 3e-11 43.9 0.1 1.2e-10 42.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO22913.1 - 7e-08 33.0 0.1 2.4e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO22913.1 - 2.5e-07 31.4 0.0 2.3e-06 28.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO22913.1 - 1.2e-06 28.4 0.0 1.2e-05 25.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain TPMT PF05724.11 KOO22913.1 - 0.025 14.2 0.0 0.054 13.1 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.20 KOO22913.1 - 0.027 13.7 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Hamartin PF04388.12 KOO22913.1 - 0.038 12.7 0.7 0.068 11.8 0.7 1.3 1 0 0 1 1 1 0 Hamartin protein CheR PF01739.18 KOO22913.1 - 0.065 12.7 0.0 0.43 10.0 0.0 1.9 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Pkinase PF00069.25 KOO22915.1 - 1.7e-45 155.4 0.0 4.2e-44 150.9 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22915.1 - 1.8e-22 79.9 0.0 3.8e-22 78.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KOO22915.1 - 0.043 13.7 5.0 0.1 12.5 0.3 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family fn3 PF00041.21 KOO22917.1 - 6.2e-09 36.1 0.0 1.2e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain TPR_2 PF07719.17 KOO22917.1 - 8.1e-05 22.4 0.0 0.064 13.4 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Pur_ac_phosph_N PF16656.5 KOO22917.1 - 0.0034 17.9 0.1 0.0068 17.0 0.1 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain TPR_1 PF00515.28 KOO22917.1 - 0.0053 16.5 0.0 4.1 7.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO22917.1 - 0.046 14.1 0.0 5.4 7.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 KOO22917.1 - 0.051 13.9 0.3 0.3 11.4 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO22917.1 - 0.051 14.2 0.0 0.16 12.7 0.0 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO22917.1 - 0.054 13.2 0.1 4.2 7.2 0.0 2.9 3 0 0 3 3 3 0 TPR repeat p25-alpha PF05517.12 KOO22917.1 - 0.088 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 p25-alpha Interfer-bind PF09294.10 KOO22917.1 - 0.1 12.9 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III PK_C PF02887.16 KOO22919.1 - 8.1e-25 87.3 0.1 1.1e-24 87.0 0.1 1.1 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain DNase-RNase PF02577.14 KOO22919.1 - 0.02 14.5 0.1 4.3 7.0 0.1 2.2 2 0 0 2 2 2 0 Bifunctional nuclease APH PF01636.23 KOO22920.1 - 1.3e-17 64.6 4.1 1.3e-17 64.6 4.1 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO22921.1 - 5e-32 111.3 0.0 7.6e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22921.1 - 2.3e-16 59.9 0.0 4.3e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO22921.1 - 0.0016 17.8 0.1 0.0028 17.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DnaJ PF00226.31 KOO22921.1 - 0.0059 16.7 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Kinase-like PF14531.6 KOO22921.1 - 0.024 14.0 0.0 0.035 13.4 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Nucleoporin_FG PF13634.6 KOO22921.1 - 1.8 9.5 6.8 1.5e+02 3.3 6.8 2.3 1 1 0 1 1 1 0 Nucleoporin FG repeat region Nop16 PF09420.10 KOO22922.1 - 1.1e-19 71.3 0.8 1.4e-14 54.7 0.0 2.1 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 UPF0029 PF01205.19 KOO22923.1 - 1.4e-26 92.8 0.0 4.2e-26 91.3 0.0 1.8 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 KOO22923.1 - 0.00016 21.9 0.0 0.00099 19.4 0.0 2.0 1 1 0 1 1 1 1 RWD domain DUF1663 PF07909.11 KOO22923.1 - 0.026 13.3 0.6 0.037 12.8 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1663) DUF3775 PF12616.8 KOO22923.1 - 0.19 11.8 0.9 0.52 10.4 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) K_channel_TID PF07941.11 KOO22923.1 - 2.1 8.9 8.0 16 6.0 1.5 2.8 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain BHD_3 PF10405.9 KOO22924.1 - 0.00052 20.4 0.0 0.00073 19.9 0.0 1.2 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 DUF501 PF04417.12 KOO22924.1 - 0.0081 16.0 1.1 0.0093 15.8 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF501) TPR_10 PF13374.6 KOO22924.1 - 0.027 14.4 2.7 0.027 14.4 2.7 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Phage_GPL PF05926.11 KOO22924.1 - 0.027 14.4 0.4 0.031 14.3 0.4 1.1 1 0 0 1 1 1 0 Phage head completion protein (GPL) Ldh_1_C PF02866.18 KOO22925.1 - 1.3e-33 116.3 0.0 1.8e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KOO22925.1 - 2.1e-30 105.7 0.1 3.5e-30 104.9 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_3_C PF01915.22 KOO22925.1 - 0.02 14.8 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain Pkinase PF00069.25 KOO22926.1 - 1.4e-44 152.4 0.0 2.1e-44 151.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO22926.1 - 5.3e-27 94.7 0.0 6.7e-27 94.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO22926.1 - 0.01 15.7 1.2 1.5 8.7 0.0 2.9 2 2 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO22926.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Nucleoporin_FG2 PF15967.5 KOO22926.1 - 0.081 11.4 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region Pkinase_fungal PF17667.1 KOO22926.1 - 0.16 10.7 0.0 0.28 9.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase peroxidase PF00141.23 KOO22927.1 - 2.8e-46 158.0 0.0 5.6e-46 157.1 0.0 1.4 1 1 0 1 1 1 1 Peroxidase SLATT_1 PF18181.1 KOO22928.1 - 0.00011 22.2 7.9 0.00012 21.9 0.2 3.2 3 0 0 3 3 3 1 SMODS and SLOG-associating 2TM effector domain 1 DUF4231 PF14015.6 KOO22928.1 - 0.037 14.5 7.2 23 5.5 0.0 3.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Kei1 PF08552.11 KOO22928.1 - 0.085 12.7 1.2 0.18 11.6 0.5 1.8 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 NPV_P10 PF05531.12 KOO22928.1 - 0.29 11.6 0.9 1 9.9 0.6 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein MT0933_antitox PF14013.6 KOO22928.1 - 4 7.8 11.7 7.4 7.0 11.7 1.4 1 0 0 1 1 1 0 MT0933-like antitoxin protein Ank_2 PF12796.7 KOO22929.1 - 4.8e-19 68.7 0.8 9.2e-11 42.2 0.3 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO22929.1 - 2.4e-16 59.6 4.7 7e-06 26.2 0.1 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO22929.1 - 2.5e-15 56.6 1.6 2e-07 31.4 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22929.1 - 6.6e-13 47.6 3.5 0.0034 17.7 0.1 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 KOO22929.1 - 3.4e-06 27.3 10.3 0.15 12.5 0.2 4.3 5 0 0 5 5 5 3 Ankyrin repeat OCRE PF17780.1 KOO22931.1 - 6e-07 29.4 0.0 1.3e-06 28.3 0.0 1.5 1 1 0 1 1 1 1 OCRE domain PRP1_N PF06424.12 KOO22931.1 - 0.091 13.2 14.5 1.3 9.5 14.5 2.4 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal fn3 PF00041.21 KOO22932.1 - 6.8e-09 36.0 0.0 1.3e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain EF-hand_1 PF00036.32 KOO22932.1 - 5.3e-08 31.9 0.1 7.7e-07 28.2 0.1 2.6 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 KOO22932.1 - 3.1e-05 23.5 0.1 0.0017 18.2 0.1 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO22932.1 - 0.00016 22.0 0.0 0.00086 19.7 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO22932.1 - 0.00017 20.9 0.1 0.00017 20.9 0.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO22932.1 - 0.0017 18.2 0.1 0.01 15.7 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair SOAR PF16533.5 KOO22932.1 - 0.011 15.7 0.8 0.038 14.0 0.6 2.0 1 1 0 1 1 1 0 STIM1 Orai1-activating region EF-hand_4 PF12763.7 KOO22932.1 - 0.093 12.7 0.0 0.24 11.3 0.0 1.6 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand ATP_bind_3 PF01171.20 KOO22933.1 - 5.6e-34 117.5 0.0 9.6e-34 116.7 0.0 1.3 1 0 0 1 1 1 1 PP-loop family QueC PF06508.13 KOO22933.1 - 0.00046 19.7 0.0 0.0015 18.1 0.0 1.7 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 KOO22933.1 - 0.04 13.6 0.0 0.087 12.5 0.0 1.5 1 0 0 1 1 1 0 Asparagine synthase Methyltransf_28 PF02636.17 KOO22935.1 - 8.3e-21 74.8 0.0 9.9e-20 71.2 0.0 2.6 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase LCE6A PF15858.5 KOO22935.1 - 0.18 12.6 1.6 0.3 11.9 0.1 2.1 2 0 0 2 2 2 0 Late cornified envelope protein 6A family Rsm22 PF09243.10 KOO22936.1 - 2.1e-17 63.3 0.0 4.3e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Hydrolase_like PF13242.6 KOO22936.1 - 7.8e-17 61.1 0.0 2e-16 59.8 0.0 1.8 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 KOO22936.1 - 2.5e-08 33.9 0.0 5.5e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO22936.1 - 0.0011 19.2 0.2 0.0041 17.4 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOO22936.1 - 0.28 11.3 0.0 0.49 10.5 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase RCC1 PF00415.18 KOO22938.1 - 1.7e-53 179.0 15.5 3.4e-12 46.8 0.4 7.1 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO22938.1 - 1.9e-15 56.2 38.7 1.2e-05 25.0 0.8 7.3 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat TauE PF01925.19 KOO22939.1 - 1.9e-12 47.3 18.8 3.1e-12 46.6 18.8 1.3 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE Phenol_monoox PF04663.12 KOO22939.1 - 0.11 12.6 0.3 17 5.6 0.0 2.6 2 0 0 2 2 2 0 Phenol hydroxylase conserved region URO-D PF01208.17 KOO22940.1 - 1.4e-104 349.9 0.1 1.7e-104 349.7 0.1 1.1 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) C2 PF00168.30 KOO22941.1 - 0.087 13.1 0.0 4.3 7.7 0.0 2.3 2 0 0 2 2 2 0 C2 domain BNR_2 PF13088.6 KOO22942.1 - 1.5e-19 70.4 0.0 2.1e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.6 KOO22942.1 - 4.4e-07 29.5 0.0 9.7e-06 25.1 0.0 2.1 2 0 0 2 2 2 1 BNR repeat-like domain BNR PF02012.20 KOO22942.1 - 0.0016 18.2 26.0 0.27 11.4 0.4 5.5 5 0 0 5 5 5 4 BNR/Asp-box repeat BNR_6 PF15899.5 KOO22942.1 - 0.002 18.0 1.6 0.75 10.0 0.6 2.7 2 0 0 2 2 2 2 BNR-Asp box repeat Sortilin-Vps10 PF15902.5 KOO22942.1 - 0.046 12.5 0.4 8.1 5.1 0.0 3.1 3 1 0 4 4 4 0 Sortilin, neurotensin receptor 3, DUF4185 PF13810.6 KOO22942.1 - 0.052 12.8 0.0 0.19 10.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4185) Beta_helix PF13229.6 KOO22943.1 - 3.6e-13 49.7 0.2 5.2e-13 49.1 0.2 1.1 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 KOO22943.1 - 2.1e-06 27.2 0.0 2.8e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.11 KOO22943.1 - 0.033 13.5 0.0 1.7 7.9 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1565) CS PF04969.16 KOO22944.1 - 1.1e-06 29.5 0.0 1.6e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 CS domain DNA_pol_B_thumb PF14791.6 KOO22945.1 - 0.00035 20.7 0.0 0.0011 19.1 0.0 1.9 1 0 0 1 1 1 1 DNA polymerase beta thumb Kinesin PF00225.23 KOO22946.1 - 9.8e-78 261.4 0.0 1.4e-77 260.9 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain VCBS PF13517.6 KOO22946.1 - 7.2e-13 48.9 8.6 7.6e-05 23.2 0.8 5.8 4 1 2 6 6 6 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Microtub_bd PF16796.5 KOO22946.1 - 9.9e-11 41.8 0.0 1.7e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding PQQ_2 PF13360.6 KOO22946.1 - 1.9e-08 34.2 9.9 2.6e-06 27.2 4.2 3.1 3 1 1 4 4 4 2 PQQ-like domain FG-GAP PF01839.23 KOO22946.1 - 2.5e-08 33.9 19.0 0.0025 17.9 0.6 5.7 5 0 0 5 5 5 2 FG-GAP repeat PQQ PF01011.21 KOO22946.1 - 6.8e-05 22.6 0.1 1.6 8.8 0.1 5.3 7 0 0 7 7 7 2 PQQ enzyme repeat PQQ_3 PF13570.6 KOO22946.1 - 0.0024 18.3 20.7 11 6.7 0.5 6.9 6 0 0 6 6 6 3 PQQ-like domain TcdB_toxin_midN PF12256.8 KOO22946.1 - 0.063 12.6 5.6 6.7 6.0 0.0 4.0 3 1 1 4 4 4 0 Insecticide toxin TcdB middle/N-terminal region AAA_30 PF13604.6 KOO22946.1 - 0.65 9.7 4.4 0.16 11.7 0.8 1.8 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 KOO22947.1 - 1.3e-67 228.5 0.0 1.9e-67 228.0 0.0 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 KOO22947.1 - 1.7e-41 142.7 0.0 1.8e-27 96.6 0.0 3.1 3 0 0 3 3 3 3 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 KOO22947.1 - 1.8e-34 119.1 0.1 5.5e-34 117.6 0.1 1.9 1 0 0 1 1 1 1 AAA domain SRF-TF PF00319.18 KOO22947.1 - 1.2e-16 59.9 0.1 2.2e-16 59.0 0.1 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) UvrD_C_2 PF13538.6 KOO22947.1 - 3.9e-11 42.6 0.2 2e-10 40.3 0.2 2.2 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 KOO22947.1 - 5.5e-05 23.0 4.9 0.00015 21.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.6 KOO22947.1 - 0.0002 21.0 0.0 0.00075 19.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 KOO22947.1 - 0.00056 19.7 0.3 0.028 14.1 0.0 2.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 KOO22947.1 - 0.0012 18.7 0.1 0.0024 17.7 0.1 1.5 1 1 0 1 1 1 1 AAA domain p450 PF00067.22 KOO22948.1 - 2.4e-11 43.1 0.2 1.2e-09 37.5 0.4 2.0 2 0 0 2 2 2 2 Cytochrome P450 TilS PF09179.11 KOO22948.1 - 2.7 8.5 6.0 16 6.1 0.6 3.0 2 1 1 3 3 3 0 TilS substrate binding domain DUF4071 PF13281.6 KOO22949.1 - 0.0051 15.9 0.1 0.45 9.5 0.0 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4071) Ras PF00071.22 KOO22949.1 - 0.099 12.2 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Ras family DUF99 PF01949.16 KOO22949.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF99 MaoC_dehydrat_N PF13452.6 KOO22950.1 - 0.071 13.2 0.0 0.09 12.9 0.0 1.1 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase Steroid_dh PF02544.16 KOO22951.1 - 1.4e-35 122.5 0.1 1.6e-35 122.3 0.1 1.0 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 KOO22951.1 - 0.008 15.7 0.0 0.0092 15.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) EF-hand_1 PF00036.32 KOO22954.1 - 3.2e-26 88.9 5.4 3.6e-05 23.0 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO22954.1 - 5.8e-24 81.9 4.7 2.1e-05 24.1 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO22954.1 - 8.6e-23 78.8 3.3 4.1e-05 22.9 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO22954.1 - 1.8e-19 70.0 3.5 4.2e-09 36.7 0.1 3.1 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO22954.1 - 5.8e-16 58.1 8.8 0.00012 21.8 0.9 4.3 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO22954.1 - 0.00075 19.8 2.1 0.6 10.5 0.0 3.3 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO22954.1 - 0.044 13.7 0.2 2.3 8.1 0.1 2.6 1 1 2 3 3 3 0 Caleosin related protein EF-hand_9 PF14658.6 KOO22954.1 - 0.072 13.4 0.4 5.7 7.3 0.0 2.9 3 1 0 3 3 3 0 EF-hand domain RAP PF08373.10 KOO22955.1 - 3.5e-11 43.0 0.0 1.3e-10 41.2 0.0 2.0 2 0 0 2 2 2 1 RAP domain MTES_1575 PF18741.1 KOO22955.1 - 0.0022 18.1 0.0 0.0071 16.5 0.0 1.8 2 0 0 2 2 2 1 REase_MTES_1575 PufQ PF05398.11 KOO22955.1 - 3.5 7.8 5.1 6.8 6.9 0.3 3.1 3 0 0 3 3 3 0 PufQ cytochrome subunit SGL PF08450.12 KOO22956.1 - 4.2e-09 36.3 0.0 0.13 11.8 0.0 4.1 2 2 2 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 KOO22956.1 - 1.2e-07 31.4 2.3 0.1 12.7 0.1 4.4 5 0 0 5 5 5 3 NHL repeat Phytase-like PF13449.6 KOO22956.1 - 0.0029 17.6 0.0 3.3 7.6 0.0 3.2 2 2 1 3 3 3 2 Esterase-like activity of phytase PQQ_2 PF13360.6 KOO22956.1 - 0.0069 16.0 0.0 0.033 13.8 0.0 1.9 2 1 1 3 3 3 1 PQQ-like domain SdiA-regulated PF06977.11 KOO22956.1 - 0.029 13.6 0.0 1.6 7.9 0.0 2.2 2 0 0 2 2 2 0 SdiA-regulated Reg_prop PF07494.11 KOO22956.1 - 0.15 12.4 0.0 10 6.7 0.0 2.9 2 0 0 2 2 2 0 Two component regulator propeller VPS9 PF02204.18 KOO22957.1 - 0.027 14.7 0.0 0.053 13.7 0.0 1.4 1 0 0 1 1 1 0 Vacuolar sorting protein 9 (VPS9) domain Asp PF00026.23 KOO22959.1 - 1.5e-27 96.8 0.0 8.5e-27 94.4 0.0 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO22959.1 - 5.9e-08 33.2 0.1 1.1e-05 25.8 0.1 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Methyltransf_24 PF13578.6 KOO22962.1 - 2.1e-09 38.3 1.6 2.8e-09 37.9 0.3 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_3 PF01596.17 KOO22962.1 - 2e-06 27.1 0.0 2.7e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase PRAI PF00697.22 KOO22962.1 - 0.093 12.5 0.0 1.3 8.7 0.0 2.0 2 0 0 2 2 2 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Imm49 PF15575.6 KOO22962.1 - 0.13 12.0 1.5 0.34 10.6 0.1 2.0 2 0 0 2 2 2 0 Immunity protein 49 Nuc_sug_transp PF04142.15 KOO22963.1 - 8.6e-28 97.4 7.5 1e-27 97.2 7.5 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter DUF4126 PF13548.6 KOO22963.1 - 0.0082 15.8 7.4 0.01 15.5 7.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4126) UAA PF08449.11 KOO22963.1 - 0.048 12.9 2.1 0.049 12.8 2.1 1.2 1 0 0 1 1 1 0 UAA transporter family Kinesin PF00225.23 KOO22964.1 - 7.5e-83 278.2 0.0 9.1e-83 277.9 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO22964.1 - 8.3e-16 58.3 0.0 3.9e-15 56.1 0.0 2.0 1 1 0 1 1 1 1 Microtubule binding HALZ PF02183.18 KOO22964.1 - 0.00087 19.5 7.0 0.15 12.3 0.2 3.8 4 1 0 4 4 4 2 Homeobox associated leucine zipper bZIP_1 PF00170.21 KOO22964.1 - 0.09 12.9 4.0 5 7.3 0.1 3.5 3 0 0 3 3 3 0 bZIP transcription factor PRKG1_interact PF15898.5 KOO22964.1 - 0.22 12.4 5.0 4.4 8.3 0.0 2.9 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4763 PF15960.5 KOO22964.1 - 0.39 10.0 3.6 0.75 9.0 0.7 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4763) YabA PF06156.13 KOO22964.1 - 0.51 11.0 6.5 8.1 7.2 0.1 3.4 2 1 1 3 3 3 0 Initiation control protein YabA K-box PF01486.17 KOO22964.1 - 0.73 10.1 5.3 14 5.9 0.1 2.4 2 0 0 2 2 2 0 K-box region TMF_TATA_bd PF12325.8 KOO22964.1 - 0.75 10.0 9.0 19 5.5 0.1 3.4 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4140 PF13600.6 KOO22964.1 - 0.91 10.0 13.2 1.5 9.3 0.1 3.8 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) CENP-F_leu_zip PF10473.9 KOO22964.1 - 0.91 9.5 4.8 25 4.9 0.0 3.4 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 KOO22964.1 - 1 9.2 14.6 0.83 9.5 0.3 3.5 3 0 0 3 3 3 0 Septum formation initiator JIP_LZII PF16471.5 KOO22964.1 - 2.6 8.3 4.7 7.6 6.8 0.2 2.9 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II Cep57_CLD_2 PF14197.6 KOO22964.1 - 4.5 7.4 11.2 4.5 7.4 0.9 3.4 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 ZapB PF06005.12 KOO22964.1 - 5.5 7.5 14.5 20 5.7 0.2 3.6 3 1 0 3 3 3 0 Cell division protein ZapB GIT_CC PF16559.5 KOO22964.1 - 7 6.6 9.2 24 4.9 0.7 3.5 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor JAKMIP_CC3 PF16034.5 KOO22964.1 - 9.7 6.1 8.3 4.2 7.3 3.7 2.4 1 1 1 2 2 2 0 JAKMIP CC3 domain Methyltransf_11 PF08241.12 KOO22965.1 - 3.6e-12 46.8 0.0 8.5e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO22965.1 - 2.8e-09 37.6 0.0 6.5e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO22965.1 - 1.2e-06 28.5 0.0 1.9e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO22965.1 - 6.4e-05 22.8 0.0 0.0001 22.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO22965.1 - 0.00022 20.6 0.0 0.00053 19.4 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 KOO22965.1 - 0.0011 19.7 0.0 0.0022 18.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KOO22965.1 - 0.019 14.8 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase CMAS PF02353.20 KOO22965.1 - 0.023 14.0 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF4538 PF15061.6 KOO22965.1 - 0.09 12.5 0.0 0.22 11.3 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Herpes_DNAp_acc PF04929.12 KOO22965.1 - 0.098 11.6 1.7 0.17 10.8 1.7 1.4 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Methyltransf_29 PF03141.16 KOO22965.1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase S1 PF00575.23 KOO22966.1 - 2.3e-07 31.1 0.2 3.2e-07 30.6 0.2 1.2 1 0 0 1 1 1 1 S1 RNA binding domain Ret2_MD PF18528.1 KOO22966.1 - 0.067 13.6 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 RNA editing 3' terminal uridylyl transferase 2 middle domain UQ_con PF00179.26 KOO22967.1 - 5e-34 116.9 0.0 5.7e-34 116.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Bestrophin PF01062.21 KOO22968.1 - 6.8e-22 78.2 0.0 1.3e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel APH PF01636.23 KOO22968.1 - 0.018 15.0 1.6 0.068 13.1 0.1 2.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family ADH_zinc_N_2 PF13602.6 KOO22969.1 - 2.4e-10 41.6 0.0 4.6e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOO22969.1 - 7.6e-10 38.9 0.0 1.5e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Eno-Rase_NADH_b PF12242.8 KOO22969.1 - 0.1 12.4 3.0 0.84 9.4 0.2 2.6 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ELFV_dehydrog PF00208.21 KOO22969.1 - 0.19 11.4 0.4 0.56 9.9 0.2 1.8 1 1 1 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Arm PF00514.23 KOO22970.1 - 0.00011 22.2 9.1 0.089 12.9 0.1 4.0 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat Kinesin PF00225.23 KOO22971.1 - 2.7e-43 148.2 0.0 4.3e-43 147.5 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain IQ PF00612.27 KOO22971.1 - 1.8e-07 30.3 29.3 0.11 12.3 1.1 6.6 6 0 0 6 6 6 4 IQ calmodulin-binding motif EF-hand_6 PF13405.6 KOO22971.1 - 0.0017 18.1 1.0 0.067 13.2 0.2 2.7 2 0 0 2 2 2 1 EF-hand domain Microtub_bd PF16796.5 KOO22971.1 - 0.0048 16.8 0.0 0.0098 15.8 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding EF-hand_5 PF13202.6 KOO22971.1 - 0.09 12.3 0.9 8.4 6.1 0.1 2.6 2 0 0 2 2 2 0 EF hand AAA_19 PF13245.6 KOO22971.1 - 0.14 12.5 0.2 0.87 9.9 0.1 2.4 2 0 0 2 2 2 0 AAA domain EF-hand_1 PF00036.32 KOO22971.1 - 0.17 11.5 2.0 0.34 10.6 0.5 2.2 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 KOO22971.1 - 0.34 11.4 0.8 1.1 9.8 0.2 1.9 1 1 1 2 2 2 0 EF-hand domain pair Nuc_sug_transp PF04142.15 KOO22972.1 - 3.8e-73 246.4 2.8 4.8e-73 246.1 2.8 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 KOO22972.1 - 5.1e-10 39.0 4.3 1.2e-09 37.9 4.1 1.7 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.20 KOO22972.1 - 2.5e-06 27.7 27.3 9.5e-06 25.8 3.3 2.5 2 0 0 2 2 2 2 EamA-like transporter family Sugar_transport PF06800.12 KOO22972.1 - 0.0076 15.6 4.4 0.059 12.7 0.1 2.5 2 0 0 2 2 2 1 Sugar transport protein TPT PF03151.16 KOO22972.1 - 0.0091 15.4 2.7 0.011 15.1 0.1 2.2 2 1 0 2 2 2 1 Triose-phosphate Transporter family PUNUT PF16913.5 KOO22972.1 - 0.39 9.9 14.2 0.11 11.6 4.9 2.9 1 1 2 3 3 3 0 Purine nucleobase transmembrane transport Ribosomal_L1 PF00687.21 KOO22974.1 - 1.6e-40 139.0 1.5 2e-40 138.7 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family CIAPIN1 PF05093.13 KOO22974.1 - 0.054 14.0 0.3 0.18 12.3 0.1 1.9 1 1 1 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Tubulin PF00091.25 KOO22975.1 - 2.4e-41 142.1 1.1 3.5e-41 141.6 1.1 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.8 KOO22975.1 - 1.9e-30 105.0 0.6 1.9e-30 105.0 0.6 2.1 2 0 0 2 2 2 1 FtsZ family, C-terminal domain Tubulin_2 PF13809.6 KOO22975.1 - 0.00033 19.9 6.0 0.015 14.5 2.0 2.3 1 1 1 2 2 2 2 Tubulin like LDcluster4 PF18306.1 KOO22975.1 - 0.014 14.9 1.1 0.12 11.9 0.8 2.3 2 0 0 2 2 2 0 SLOG cluster4 family Ribosomal_S9 PF00380.19 KOO22978.1 - 1.9e-40 138.1 0.5 2.2e-40 137.9 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 HEAT PF02985.22 KOO22979.1 - 9.9e-33 109.4 51.1 9.9e-05 22.3 0.1 21.1 23 0 0 23 23 22 8 HEAT repeat HEAT_2 PF13646.6 KOO22979.1 - 1.4e-23 83.0 87.7 1.8e-06 28.2 0.6 19.0 12 5 8 21 21 19 8 HEAT repeats HEAT_EZ PF13513.6 KOO22979.1 - 3e-23 81.9 111.1 8.2e-08 32.6 0.0 23.3 20 5 7 27 27 23 10 HEAT-like repeat Cnd1 PF12717.7 KOO22979.1 - 9.6e-17 61.5 0.0 0.026 14.6 0.0 7.0 7 0 0 7 7 7 4 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 KOO22979.1 - 6.4e-12 45.5 0.0 0.17 11.4 0.0 6.1 6 1 1 7 7 7 4 CLASP N terminal Adaptin_N PF01602.20 KOO22979.1 - 8.6e-12 44.4 0.0 0.028 13.0 0.0 6.5 7 0 0 7 7 7 3 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 KOO22979.1 - 1.6e-11 44.7 0.0 0.47 11.1 0.0 7.3 6 2 1 7 7 6 3 Vacuolar 14 Fab1-binding region UME PF08064.13 KOO22979.1 - 9e-08 32.0 0.4 0.9 9.5 0.0 7.4 7 2 1 8 8 7 1 UME (NUC010) domain MMS19_C PF12460.8 KOO22979.1 - 4.7e-07 29.3 8.4 2.3 7.2 0.2 7.2 6 2 2 8 8 8 5 RNAPII transcription regulator C-terminal ParcG PF10274.9 KOO22979.1 - 2.1e-06 28.0 0.1 1 9.5 0.0 5.4 2 2 4 6 6 6 2 Parkin co-regulated protein RTP1_C1 PF10363.9 KOO22979.1 - 0.00019 21.6 7.1 17 5.7 0.1 7.8 8 0 0 8 8 8 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3535 PF12054.8 KOO22979.1 - 0.00036 19.9 4.7 1.4 8.1 0.0 5.1 6 1 0 6 6 6 2 Domain of unknown function (DUF3535) Cohesin_HEAT PF12765.7 KOO22979.1 - 0.0041 17.4 0.2 5.8 7.3 0.1 4.0 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Dopey_N PF04118.14 KOO22979.1 - 0.0044 16.2 0.1 5.2 6.1 0.0 4.0 3 1 1 4 4 4 1 Dopey, N-terminal DUF3437 PF11919.8 KOO22979.1 - 0.31 11.0 4.4 9.8 6.2 0.1 5.1 4 0 0 4 4 3 0 Domain of unknown function (DUF3437) API5 PF05918.11 KOO22979.1 - 0.91 8.3 9.0 3.2 6.5 0.0 4.3 6 0 0 6 6 5 0 Apoptosis inhibitory protein 5 (API5) YukD PF08817.10 KOO22979.1 - 8.4 7.2 11.9 6.8 7.5 0.3 5.3 5 0 0 5 5 5 0 WXG100 protein secretion system (Wss), protein YukD ASH PF15780.5 KOO22980.1 - 2.1e-17 63.1 0.5 0.045 14.0 0.0 10.6 11 1 0 11 11 11 5 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 KOO22980.1 - 7e-08 32.6 0.2 0.00045 20.3 0.0 5.4 6 0 0 6 6 6 1 Flagellar-associated PapD-like Motile_Sperm PF00635.26 KOO22980.1 - 0.00015 21.6 0.1 6.9 6.6 0.1 6.3 8 0 0 8 8 8 1 MSP (Major sperm protein) domain TMEM131_like PF12371.8 KOO22980.1 - 0.00099 19.3 0.1 8.6 6.7 0.0 5.5 6 0 0 6 6 6 1 Transmembrane protein 131-like DUF2742 PF10888.8 KOO22980.1 - 0.12 12.6 0.2 0.46 10.8 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2742) Agenet PF05641.12 KOO22981.1 - 1.3e-15 57.6 4.5 1.7e-11 44.4 1.0 2.8 2 0 0 2 2 2 2 Agenet domain Chromo PF00385.24 KOO22981.1 - 1.8e-05 24.5 1.0 6.4e-05 22.8 0.1 2.5 2 1 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Lzipper-MIP1 PF14389.6 KOO22981.1 - 0.026 14.8 1.1 0.13 12.6 0.1 2.5 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Herpes_UL25 PF01499.16 KOO22981.1 - 0.073 11.6 0.9 0.13 10.8 0.9 1.3 1 0 0 1 1 1 0 Herpesvirus UL25 family Dynamin_N PF00350.23 KOO22982.1 - 1.3e-21 77.4 0.0 2.4e-21 76.5 0.0 1.5 1 0 0 1 1 1 1 Dynamin family U-box PF04564.15 KOO22982.1 - 5.3e-13 48.9 0.0 1.5e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 U-box domain Dynamin_M PF01031.20 KOO22982.1 - 6.5e-06 25.6 0.0 8.3e-05 21.9 0.0 2.3 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 KOO22982.1 - 1.5e-05 25.0 0.1 0.00012 22.1 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase zf-Nse PF11789.8 KOO22982.1 - 0.0001 22.0 0.0 0.00023 20.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 KOO22982.1 - 0.021 14.9 0.0 0.048 13.7 0.0 1.6 1 0 0 1 1 1 0 RING-type zinc-finger FdsD PF11390.8 KOO22982.1 - 0.038 14.3 0.1 0.16 12.3 0.1 2.1 1 0 0 1 1 1 0 NADH-dependant formate dehydrogenase delta subunit FdsD CO_deh_flav_C PF03450.17 KOO22982.1 - 0.042 14.0 0.3 0.13 12.4 0.3 1.8 1 0 0 1 1 1 0 CO dehydrogenase flavoprotein C-terminal domain Roc PF08477.13 KOO22982.1 - 0.066 13.4 0.1 0.18 12.0 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 KOO22982.1 - 0.079 13.2 0.3 0.3 11.3 0.3 2.2 1 1 0 1 1 1 0 AAA domain Phage_lysozyme PF00959.19 KOO22983.1 - 0.078 13.4 0.0 0.16 12.5 0.0 1.5 1 1 1 2 2 2 0 Phage lysozyme UvrD_C_2 PF13538.6 KOO22984.1 - 9.5e-10 38.2 0.1 0.002 17.9 0.1 2.7 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C PF13361.6 KOO22984.1 - 8.3e-09 35.3 0.0 7.1e-08 32.2 0.0 2.0 1 1 1 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 KOO22984.1 - 0.00029 21.2 0.1 0.00073 19.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 KOO22984.1 - 0.00037 20.1 0.0 0.00065 19.3 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Dermcidin PF15291.6 KOO22984.1 - 0.018 15.5 1.0 0.05 14.2 1.0 1.7 1 0 0 1 1 1 0 Dermcidin, antibiotic peptide Viral_helicase1 PF01443.18 KOO22984.1 - 0.15 11.7 0.2 16 5.1 0.1 2.8 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase ANAPC4_WD40 PF12894.7 KOO22986.1 - 2.1e-12 47.2 2.1 0.003 17.8 0.1 7.5 5 2 4 9 9 9 3 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 KOO22986.1 - 0.042 13.6 2.1 2.9 7.6 2.0 3.5 2 1 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain SdiA-regulated PF06977.11 KOO22986.1 - 0.082 12.1 0.0 1 8.5 0.0 2.6 2 1 0 2 2 2 0 SdiA-regulated SRP14 PF02290.15 KOO22987.1 - 8.6e-18 64.5 0.1 1.6e-17 63.6 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle 14kD protein Ank_2 PF12796.7 KOO22988.1 - 7.8e-18 64.8 0.0 1.9e-11 44.4 0.0 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO22988.1 - 4.9e-12 46.1 0.0 2.7e-06 27.8 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO22988.1 - 9.7e-11 40.9 0.0 0.0038 17.6 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KOO22988.1 - 2.2e-10 40.6 0.2 1.1e-06 28.8 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO22988.1 - 2.2e-08 34.2 0.1 0.0012 19.2 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat PKS_DE PF18369.1 KOO22988.1 - 0.0016 18.9 3.1 0.0026 18.3 0.0 2.8 3 0 0 3 3 3 1 Polyketide synthase dimerisation element domain ADH_N PF08240.12 KOO22989.1 - 2.3e-21 75.7 1.8 3.3e-21 75.2 1.8 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOO22989.1 - 1.3e-16 60.8 0.0 2.6e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOO22989.1 - 5.6e-08 33.9 0.0 9.9e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 KOO22989.1 - 0.0088 15.4 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain BKACE PF05853.12 KOO22989.1 - 0.17 11.2 0.0 0.28 10.4 0.0 1.4 2 0 0 2 2 2 0 beta-keto acid cleavage enzyme PEP-utilisers_N PF05524.13 KOO22990.1 - 0.059 13.6 6.3 0.15 12.2 0.1 3.2 3 0 0 3 3 3 0 PEP-utilising enzyme, N-terminal Serine_rich PF08824.10 KOO22990.1 - 0.11 12.5 0.3 2.8 7.9 0.0 2.7 3 0 0 3 3 3 0 Serine rich protein interaction domain YrhK PF14145.6 KOO22991.1 - 2.1e-08 33.9 28.0 0.0048 16.7 4.7 3.9 2 1 1 3 3 3 3 YrhK-like protein EF-hand_1 PF00036.32 KOO22992.1 - 3.4e-15 54.4 2.4 6.2e-07 28.5 1.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO22992.1 - 8.8e-15 54.9 9.8 3.4e-08 33.8 1.6 2.2 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO22992.1 - 9.5e-15 53.3 4.8 1.2e-06 27.8 1.4 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO22992.1 - 1.2e-13 49.8 1.6 5.3e-07 29.0 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO22992.1 - 5.2e-10 39.0 1.2 0.00072 19.4 0.5 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO22992.1 - 4.2e-06 26.7 0.1 9.1e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO22992.1 - 0.003 17.8 0.2 0.14 12.5 0.1 2.2 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO22992.1 - 0.078 13.2 1.8 1.3 9.2 0.2 2.1 1 1 1 2 2 2 0 Dockerin type I domain VCBS PF13517.6 KOO22992.1 - 0.11 13.1 1.7 2.1 9.0 0.1 2.2 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Excalibur PF05901.11 KOO22992.1 - 4.2 8.1 6.5 11 6.7 0.1 2.9 2 1 0 2 2 2 0 Excalibur calcium-binding domain Drf_FH3 PF06367.16 KOO22993.1 - 0.037 13.6 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 Diaphanous FH3 Domain Tic22 PF04278.12 KOO22994.1 - 3e-11 43.2 0.0 4e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Tic22-like family Phe_tRNA-synt_N PF02912.18 KOO22995.1 - 0.1 12.5 0.2 0.1 12.5 0.2 2.1 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain Glyco_transf_29 PF00777.18 KOO22996.1 - 0.021 14.2 0.3 0.026 13.9 0.0 1.3 2 0 0 2 2 2 0 Glycosyltransferase family 29 (sialyltransferase) PALP PF00291.25 KOO22997.1 - 3.1e-73 246.8 3.5 4.1e-73 246.4 3.5 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.25 KOO22997.1 - 0.0019 17.9 1.8 0.0079 15.9 0.0 2.7 3 0 0 3 3 3 1 ACT domain ACT_4 PF13291.6 KOO22997.1 - 0.018 15.7 0.0 0.042 14.4 0.0 1.6 1 0 0 1 1 1 0 ACT domain TPMT PF05724.11 KOO22997.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) E2F_TDP PF02319.20 KOO22998.1 - 2.4e-19 69.2 0.0 4.8e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain DP PF08781.10 KOO22998.1 - 1.1e-06 28.6 0.0 1.9e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Transcription factor DP Peripla_BP_2 PF01497.18 KOO22998.1 - 0.092 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein MAGE_N PF12440.8 KOO22998.1 - 1.8 9.3 6.8 0.14 12.9 1.0 2.1 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal PHD PF00628.29 KOO22999.1 - 4.9e-05 23.1 4.0 4.9e-05 23.1 4.0 3.0 2 1 1 3 3 3 1 PHD-finger Terminase_GpA PF05876.12 KOO22999.1 - 3.3 6.1 9.8 2.9 6.3 6.5 1.9 1 1 1 2 2 2 0 Phage terminase large subunit (GpA) zf-C2H2_jaz PF12171.8 KOO22999.1 - 5 7.5 6.2 20 5.6 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Fez1 PF06818.15 KOO23000.1 - 0.0047 17.4 0.9 0.0066 16.9 0.9 1.2 1 0 0 1 1 1 1 Fez1 DUF2489 PF10675.9 KOO23000.1 - 0.045 13.7 6.2 0.082 12.8 6.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2489) Atg14 PF10186.9 KOO23000.1 - 0.17 10.9 1.8 0.25 10.4 1.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PepSY_2 PF13670.6 KOO23000.1 - 1.8 8.6 9.4 5 7.2 1.8 2.8 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain LRR_6 PF13516.6 KOO23001.1 - 2.5e-18 64.5 13.6 0.00011 22.0 0.1 8.7 10 0 0 10 10 10 5 Leucine Rich repeat LRR_1 PF00560.33 KOO23001.1 - 3.5e-06 26.8 0.1 9.1 7.3 0.0 6.1 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_4 PF12799.7 KOO23001.1 - 5.4e-05 23.5 4.7 0.58 10.7 0.0 6.0 4 2 3 7 7 7 3 Leucine Rich repeats (2 copies) Exostosin PF03016.15 KOO23002.1 - 7.5e-20 71.3 0.0 1e-19 70.9 0.0 1.2 1 0 0 1 1 1 1 Exostosin family LRR_8 PF13855.6 KOO23003.1 - 5.5e-09 35.7 3.1 0.055 13.2 0.0 4.8 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 KOO23003.1 - 0.024 15.1 0.6 6.8 7.3 0.0 4.0 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) PhrC_PhrF PF11131.8 KOO23003.1 - 0.15 11.7 1.1 0.45 10.1 1.1 1.9 1 0 0 1 1 1 0 Rap-phr extracellular signalling LRR_1 PF00560.33 KOO23003.1 - 0.78 10.5 9.5 27 5.8 0.1 6.3 8 0 0 8 8 8 0 Leucine Rich Repeat Aldo_ket_red PF00248.21 KOO23004.1 - 2.8e-29 102.3 0.0 1.7e-26 93.1 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family BCLP PF12304.8 KOO23004.1 - 0.0053 16.3 0.2 0.0082 15.7 0.2 1.3 1 0 0 1 1 1 1 Beta-casein like protein AAA_6 PF12774.7 KOO23005.1 - 9.4e-153 507.9 0.0 5.9e-152 505.3 0.0 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO23005.1 - 4.2e-143 477.2 1.6 4.2e-143 477.2 1.6 2.9 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 KOO23005.1 - 1.1e-103 346.7 0.0 3e-103 345.2 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KOO23005.1 - 8.2e-86 286.7 0.5 2.2e-85 285.3 0.5 1.8 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_8 PF12780.7 KOO23005.1 - 6.8e-80 268.1 0.5 2e-72 243.7 0.0 3.0 2 1 1 3 3 3 2 P-loop containing dynein motor region D4 AAA_7 PF12775.7 KOO23005.1 - 7e-72 240.7 0.0 1e-69 233.7 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region MT PF12777.7 KOO23005.1 - 3.7e-53 180.7 9.2 1e-52 179.3 9.2 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 KOO23005.1 - 6.9e-53 178.8 0.0 1.7e-52 177.6 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 KOO23005.1 - 2.1e-30 105.4 0.1 9.4e-30 103.4 0.1 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KOO23005.1 - 7.4e-23 80.6 0.1 4.4e-22 78.2 0.2 2.3 2 0 0 2 2 1 1 AAA+ lid domain Dynein_heavy PF03028.15 KOO23005.1 - 1e-12 48.2 0.0 2.3e-11 43.8 0.0 3.2 2 1 1 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 KOO23005.1 - 3.1e-10 40.2 0.0 0.032 14.2 0.0 5.8 4 2 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA PF00004.29 KOO23005.1 - 0.00014 22.3 0.0 1.3 9.4 0.0 3.9 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO23005.1 - 0.00018 21.9 0.0 1.3 9.4 0.0 3.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 KOO23005.1 - 0.0021 18.3 0.4 9.6 6.5 0.0 4.9 5 0 0 5 5 4 0 AAA domain RNA_helicase PF00910.22 KOO23005.1 - 0.0099 16.3 0.1 4.4 7.8 0.0 3.6 3 0 0 3 3 3 1 RNA helicase DUF1202 PF06717.11 KOO23005.1 - 0.013 14.9 3.6 0.032 13.7 3.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1202) NmrA PF05368.13 KOO23005.1 - 0.034 13.7 0.0 0.14 11.7 0.0 2.0 1 0 0 1 1 1 0 NmrA-like family AAA_18 PF13238.6 KOO23005.1 - 0.045 14.3 0.0 0.67 10.5 0.0 2.8 3 0 0 3 3 2 0 AAA domain Sigma54_activat PF00158.26 KOO23005.1 - 0.046 13.4 0.1 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_33 PF13671.6 KOO23005.1 - 0.056 13.6 0.0 16 5.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain Pkinase PF00069.25 KOO23006.1 - 6.6e-33 114.2 0.0 4.9e-32 111.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23006.1 - 1.5e-10 40.8 0.0 1.3e-06 28.0 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 KOO23006.1 - 0.051 12.9 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_6 PF13405.6 KOO23007.1 - 2.2e-08 33.4 0.2 0.0083 16.0 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO23007.1 - 1.8e-07 31.5 0.0 4.2e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO23007.1 - 3.2e-07 30.1 0.2 0.00074 19.3 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO23007.1 - 4.2e-05 22.8 0.7 0.05 13.2 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO23008.1 - 8.3e-24 83.8 0.5 5e-11 42.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO23008.1 - 2.6e-18 64.1 4.7 0.0021 17.5 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO23008.1 - 3.5e-17 62.0 0.3 1.8e-07 30.9 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO23008.1 - 1.6e-16 59.0 5.3 0.0038 16.6 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO23008.1 - 2.5e-15 55.0 2.8 0.0056 16.5 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain Ion_trans PF00520.31 KOO23008.1 - 9.4e-11 41.4 2.8 1.6e-10 40.6 2.8 1.4 1 0 0 1 1 1 1 Ion transport protein EF-hand_9 PF14658.6 KOO23008.1 - 1.3e-09 38.3 0.0 0.003 17.9 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain cNMP_binding PF00027.29 KOO23008.1 - 0.00057 19.9 0.0 0.0016 18.5 0.0 1.8 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain SPARC_Ca_bdg PF10591.9 KOO23008.1 - 0.0071 16.6 0.0 4.8 7.5 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO23008.1 - 0.0097 15.8 0.5 1.4 8.9 0.1 2.6 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO23008.1 - 0.047 13.9 0.6 13 6.1 0.1 2.4 2 0 0 2 2 2 0 Dockerin type I domain EF-hand_14 PF17959.1 KOO23008.1 - 0.08 13.3 0.1 20 5.6 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain Gar1 PF04410.14 KOO23009.1 - 4.8e-26 91.4 0.0 3.6e-22 78.8 0.0 2.8 2 1 1 3 3 3 2 Gar1/Naf1 RNA binding region DMP1 PF07263.11 KOO23009.1 - 1.6 7.5 11.0 0.038 12.9 3.9 1.7 2 0 0 2 2 2 0 Dentin matrix protein 1 (DMP1) Thioredoxin PF00085.20 KOO23010.1 - 9e-34 115.6 0.0 8.8e-16 57.8 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_7 PF13899.6 KOO23010.1 - 0.00011 22.4 0.0 0.42 10.8 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 KOO23010.1 - 0.00037 20.4 0.0 0.054 13.4 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_2 PF13098.6 KOO23010.1 - 0.0029 18.0 0.0 0.49 10.9 0.0 2.9 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOO23010.1 - 0.003 17.9 0.0 5 7.5 0.0 3.0 2 1 1 3 3 3 2 Thioredoxin-like Glyco_transf_29 PF00777.18 KOO23011.1 - 0.00018 21.0 0.3 0.00031 20.2 0.2 1.3 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) zf-SNAP50_C PF12251.8 KOO23012.1 - 1e-24 87.3 0.6 1.2e-24 87.1 0.6 1.1 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal EutB PF06751.11 KOO23012.1 - 0.14 10.9 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Ethanolamine ammonia lyase large subunit (EutB) MtN3_slv PF03083.16 KOO23013.1 - 3e-32 110.5 0.7 5.4e-18 64.8 0.2 2.2 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange Orai-1 PF07856.12 KOO23015.1 - 1.1e-05 25.2 3.3 0.00027 20.7 0.2 2.1 2 0 0 2 2 2 2 Mediator of CRAC channel activity DEAD PF00270.29 KOO23018.1 - 5.6e-39 133.7 0.0 5.4e-38 130.5 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO23018.1 - 7.6e-31 106.7 0.0 2.6e-30 105.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO23018.1 - 0.01 15.9 0.0 0.025 14.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 KOO23018.1 - 0.026 13.8 0.0 0.052 12.8 0.0 1.5 1 0 0 1 1 1 0 SecA DEAD-like domain zf-CCHC PF00098.23 KOO23018.1 - 1.2 9.3 6.2 0.14 12.3 1.2 2.1 2 0 0 2 2 2 0 Zinc knuckle HEAT_2 PF13646.6 KOO23019.1 - 5.3e-05 23.5 8.0 0.00013 22.2 4.0 3.6 3 0 0 3 3 3 1 HEAT repeats HEAT_PBS PF03130.16 KOO23019.1 - 5.5 8.0 19.6 1.3 9.9 0.0 5.0 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat GTP_EFTU PF00009.27 KOO23020.1 - 5.2e-07 29.4 0.0 7.1e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KOO23020.1 - 6.2e-05 23.1 0.0 0.00012 22.1 0.0 1.4 1 0 0 1 1 1 1 Translation-initiation factor 2 DSPc PF00782.20 KOO23022.1 - 7.2e-15 55.0 0.0 9.1e-15 54.6 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOO23022.1 - 0.0057 16.3 0.0 0.0076 15.8 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KOO23022.1 - 0.016 15.1 0.1 0.024 14.6 0.1 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family HAD_2 PF13419.6 KOO23024.1 - 2.9e-16 60.1 0.0 4.9e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO23024.1 - 1.2e-12 48.6 0.3 8.9e-11 42.5 0.3 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO23024.1 - 5.7e-09 35.9 0.0 1.2e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 KOO23024.1 - 1.3e-06 29.0 0.0 1.6e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DHHA1 PF02272.19 KOO23024.1 - 0.059 13.8 0.2 0.18 12.2 0.1 1.7 2 0 0 2 2 2 0 DHHA1 domain Pkinase PF00069.25 KOO23026.1 - 1.5e-33 116.3 0.0 7.9e-32 110.7 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23026.1 - 7.6e-20 71.3 0.0 4.3e-19 68.8 0.0 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase ATG11 PF10377.9 KOO23026.1 - 0.032 14.3 0.0 0.052 13.6 0.0 1.5 1 1 0 1 1 1 0 Autophagy-related protein 11 Pkinase_fungal PF17667.1 KOO23026.1 - 0.22 10.2 0.0 0.32 9.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Abhydrolase_6 PF12697.7 KOO23027.1 - 0.00022 21.9 1.8 0.00031 21.4 1.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 KOO23027.1 - 0.11 12.1 0.2 0.37 10.3 0.0 1.8 2 0 0 2 2 2 0 Dienelactone hydrolase family Aminotran_3 PF00202.21 KOO23030.1 - 7.8e-72 242.2 0.1 1e-71 241.8 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 KOO23030.1 - 0.0013 18.0 0.0 0.0019 17.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II SNF2_N PF00176.23 KOO23031.1 - 1.1e-13 50.6 0.0 1.6e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO23031.1 - 5.9e-07 29.8 0.0 1.1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TTL PF03133.15 KOO23032.1 - 5e-95 318.0 0.0 7.1e-95 317.5 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO23032.1 - 9.9e-08 31.5 0.1 0.0002 20.7 0.0 2.7 2 1 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO23032.1 - 7.2e-06 25.5 0.0 0.0031 16.8 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp Peptidase_M61_N PF17899.1 KOO23032.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase M61 N-terminal domain EnY2 PF10163.9 KOO23033.1 - 2.2e-29 101.7 0.8 2.7e-29 101.4 0.8 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 AAA_lid_4 PF17864.1 KOO23033.1 - 0.046 13.5 0.0 0.063 13.0 0.0 1.3 1 0 0 1 1 1 0 RuvB AAA lid domain Chromo PF00385.24 KOO23034.1 - 3.2e-05 23.7 0.1 5.8e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Methyltransf_25 PF13649.6 KOO23035.1 - 5.9e-06 26.9 0.1 1.2e-05 25.9 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KOO23035.1 - 0.00042 20.3 0.1 0.00065 19.6 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO23035.1 - 0.0065 17.1 0.1 0.012 16.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO23035.1 - 0.0071 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23035.1 - 0.0091 16.7 0.0 0.021 15.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO23035.1 - 0.01 15.7 1.0 0.016 15.0 1.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 KOO23035.1 - 0.1 12.2 0.3 0.18 11.4 0.3 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Retinal PF15449.6 KOO23035.1 - 0.59 7.8 8.1 1.3 6.8 0.1 2.0 2 0 0 2 2 2 0 Retinal protein WD40 PF00400.32 KOO23036.1 - 1e-68 225.5 23.5 1.9e-09 38.0 0.2 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat Chloroa_b-bind PF00504.21 KOO23036.1 - 1.4e-27 97.2 0.0 2.8e-27 96.2 0.0 1.5 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Ge1_WD40 PF16529.5 KOO23036.1 - 9.1e-21 74.2 6.3 0.099 11.6 0.0 7.1 1 1 5 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO23036.1 - 6.1e-17 61.7 5.4 0.016 15.5 0.1 6.7 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO23036.1 - 1.9e-13 50.0 7.0 0.78 9.8 0.0 7.5 7 0 0 7 7 7 6 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO23036.1 - 7.3e-10 37.8 0.1 0.64 8.3 0.0 5.4 1 1 5 6 6 6 6 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 KOO23036.1 - 2e-06 27.4 0.2 1.7 7.9 0.1 4.1 1 1 2 4 4 4 3 WD40-like domain DCX PF03607.17 KOO23036.1 - 4e-06 26.8 0.0 3.6 7.8 0.0 5.7 6 0 0 6 6 6 1 Doublecortin Dfp1_Him1_M PF08630.10 KOO23036.1 - 7e-05 23.0 4.4 13 6.0 0.0 5.4 5 0 0 5 5 5 1 Dfp1/Him1, central region Nbas_N PF15492.6 KOO23036.1 - 0.00073 19.0 6.6 7.6 5.8 0.0 5.4 1 1 4 6 6 6 2 Neuroblastoma-amplified sequence, N terminal DpaA_N PF16924.5 KOO23036.1 - 0.2 11.7 0.0 87 3.3 0.0 3.7 2 1 2 4 4 4 0 Dipicolinate synthase subunit A N-terminal domain rOmpB PF12334.8 KOO23036.1 - 0.23 10.9 6.4 23 4.4 0.0 5.3 1 1 6 7 7 7 0 Rickettsia outer membrane protein B PAN_1 PF00024.26 KOO23037.1 - 5.1e-05 23.2 0.3 0.00011 22.1 0.3 1.5 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 KOO23037.1 - 5.6e-05 23.0 0.4 0.00014 21.7 0.4 1.6 1 0 0 1 1 1 1 PAN domain fn3 PF00041.21 KOO23037.1 - 0.0032 17.8 0.1 4.2 7.8 0.0 2.6 2 0 0 2 2 2 2 Fibronectin type III domain DUF726 PF05277.12 KOO23039.1 - 2.1e-74 250.5 24.8 2.8e-63 213.9 0.0 3.8 3 1 0 3 3 3 2 Protein of unknown function (DUF726) UBA PF00627.31 KOO23039.1 - 0.0011 18.8 0.2 0.032 14.1 0.1 2.8 2 0 0 2 2 2 1 UBA/TS-N domain Ion_trans PF00520.31 KOO23040.1 - 2.5e-05 23.6 1.2 4.8e-05 22.7 1.2 1.5 1 0 0 1 1 1 1 Ion transport protein BofC_C PF08955.10 KOO23041.1 - 0.041 13.9 0.0 4.9 7.3 0.0 2.3 2 0 0 2 2 2 0 BofC C-terminal domain Ank_2 PF12796.7 KOO23042.1 - 3.3e-47 159.0 7.5 1.5e-16 60.7 0.1 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 KOO23042.1 - 4.7e-28 96.4 3.1 2.6e-05 24.4 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 KOO23042.1 - 2.1e-27 95.1 2.5 1.1e-08 35.4 0.0 6.0 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO23042.1 - 5.3e-21 72.5 2.4 8.3e-05 22.7 0.0 6.3 6 1 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 KOO23042.1 - 2.1e-20 72.5 11.0 7.7e-06 26.1 0.1 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) DUF4486 PF14858.6 KOO23043.1 - 4.1e-32 111.4 0.1 1.6e-29 102.8 0.1 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4486) Cellulase PF00150.18 KOO23044.1 - 4e-11 42.9 2.3 1e-10 41.5 2.3 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AP_endonuc_2 PF01261.24 KOO23044.1 - 0.17 11.3 0.0 0.33 10.4 0.0 1.5 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel DUF4231 PF14015.6 KOO23045.1 - 1e-05 25.9 0.2 0.00019 21.8 0.2 2.6 1 1 0 1 1 1 1 Protein of unknown function (DUF4231) Mre11_DNA_bind PF04152.14 KOO23046.1 - 3.7e-39 134.8 0.1 8.3e-39 133.6 0.1 1.6 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 KOO23046.1 - 1.8e-08 35.1 0.0 4.7e-08 33.8 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO23046.1 - 1.3e-05 25.5 0.0 2.8e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Macro PF01661.21 KOO23047.1 - 2.1e-20 72.9 0.0 3.7e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 Macro domain LRR_6 PF13516.6 KOO23048.1 - 1.3e-09 37.3 0.8 0.00019 21.2 0.0 3.6 3 0 0 3 3 3 3 Leucine Rich repeat LRR_8 PF13855.6 KOO23048.1 - 0.13 12.1 1.3 12 5.8 0.0 2.6 1 1 1 2 2 2 0 Leucine rich repeat Nbl1_Borealin_N PF10444.9 KOO23050.1 - 5.2e-09 35.6 3.8 5.7e-09 35.5 2.6 1.6 2 0 0 2 2 2 1 Nbl1 / Borealin N terminal Borealin PF10512.9 KOO23050.1 - 0.0038 17.2 1.6 0.0069 16.3 0.0 2.1 2 0 0 2 2 2 1 Cell division cycle-associated protein 8 PKD_channel PF08016.12 KOO23051.1 - 3.4e-20 72.1 10.2 4.9e-19 68.3 11.3 2.0 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 KOO23051.1 - 9.7e-11 41.4 13.4 9.7e-11 41.4 13.4 1.8 2 0 0 2 2 2 1 Ion transport protein EF-hand_6 PF13405.6 KOO23051.1 - 5.2e-08 32.2 0.3 0.0033 17.2 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO23051.1 - 8.5e-08 31.2 1.0 0.00035 19.9 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO23051.1 - 2e-06 28.2 1.3 5.3e-06 26.8 1.3 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO23051.1 - 9.5e-06 25.4 0.6 3e-05 23.8 0.2 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO23051.1 - 4.8e-05 22.7 1.9 0.00025 20.4 0.1 2.8 2 0 0 2 2 2 1 EF hand PqiA PF04403.13 KOO23052.1 - 3.6e-12 46.4 21.8 1.3e-08 34.8 6.6 3.3 4 0 0 4 4 4 2 Paraquat-inducible protein A JHBP PF06585.11 KOO23053.1 - 0.023 13.9 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Haemolymph juvenile hormone binding protein (JHBP) WW PF00397.26 KOO23055.1 - 0.0014 18.7 0.1 0.0033 17.5 0.1 1.7 1 0 0 1 1 1 1 WW domain Arm PF00514.23 KOO23056.1 - 7.1e-92 299.0 95.7 2.8e-09 36.7 0.2 31.7 32 2 0 32 32 32 21 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO23056.1 - 7.1e-19 67.7 3.2 0.0032 17.5 0.0 10.6 10 2 1 12 12 12 4 Spinocerebellar ataxia type 10 protein domain DUF5578 PF17741.1 KOO23056.1 - 5.7e-10 39.1 12.0 0.0011 18.4 0.1 7.9 7 2 1 8 8 8 2 Family of unknown function (DUF5578) V-ATPase_H_N PF03224.14 KOO23056.1 - 2.6e-07 30.2 2.2 0.99 8.6 0.7 6.1 4 1 1 5 5 5 3 V-ATPase subunit H RICTOR_N PF14664.6 KOO23056.1 - 0.0007 18.7 12.0 1.1 8.1 0.0 6.8 8 0 0 8 8 8 2 Rapamycin-insensitive companion of mTOR, N-term Cnd1 PF12717.7 KOO23056.1 - 0.0012 18.9 2.3 21 5.1 0.0 6.1 5 1 2 7 7 7 0 non-SMC mitotic condensation complex subunit 1 EF-hand_5 PF13202.6 KOO23056.1 - 0.0014 18.0 0.0 0.004 16.6 0.0 1.7 1 0 0 1 1 1 1 EF hand HEAT_EZ PF13513.6 KOO23056.1 - 0.0085 16.6 0.2 0.0085 16.6 0.2 14.0 13 4 3 16 16 16 2 HEAT-like repeat HEAT_2 PF13646.6 KOO23056.1 - 0.017 15.5 1.7 0.017 15.5 1.7 12.1 8 3 3 12 12 12 0 HEAT repeats Arm_2 PF04826.13 KOO23056.1 - 0.018 14.5 11.6 15 4.9 0.2 7.3 8 1 0 9 9 9 0 Armadillo-like DUF913 PF06025.12 KOO23056.1 - 0.032 13.2 0.0 0.19 10.6 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) MtrA PF04208.14 KOO23056.1 - 0.073 12.7 0.2 6 6.5 0.1 3.7 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit A EF-hand_1 PF00036.32 KOO23056.1 - 0.096 12.3 0.0 0.28 10.8 0.0 1.7 1 0 0 1 1 1 0 EF hand MMS19_N PF14500.6 KOO23056.1 - 0.12 11.9 2.4 1 8.9 0.1 3.5 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II TauD PF02668.16 KOO23057.1 - 2.8e-15 56.8 0.0 4.3e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 KOO23057.1 - 4e-07 30.6 0.0 1.1e-06 29.2 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF971) Arm PF00514.23 KOO23059.1 - 4.2e-49 163.2 31.0 2.3e-07 30.6 0.5 10.2 10 0 0 10 10 10 10 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO23059.1 - 1.1e-11 44.6 0.0 6.2e-06 26.2 0.0 5.0 4 2 1 6 6 6 2 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.8 KOO23059.1 - 4.4e-06 26.7 0.3 1.2 9.0 0.0 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF3361) Adaptin_N PF01602.20 KOO23059.1 - 0.00019 20.2 0.2 0.3 9.6 0.2 3.4 1 1 0 2 2 2 2 Adaptin N terminal region HEAT_2 PF13646.6 KOO23059.1 - 0.00086 19.6 36.6 0.64 10.4 3.1 6.3 2 2 4 6 6 6 3 HEAT repeats Cnd1 PF12717.7 KOO23059.1 - 0.0021 18.1 0.1 0.71 9.9 0.0 3.1 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Tubulin_2 PF13809.6 KOO23059.1 - 0.034 13.3 1.1 1.9 7.6 0.0 2.8 3 0 0 3 3 3 0 Tubulin like RYDR_ITPR PF01365.21 KOO23059.1 - 0.039 13.4 0.2 0.68 9.3 0.1 2.8 2 1 0 2 2 2 0 RIH domain DUF1840 PF08895.11 KOO23059.1 - 0.32 11.4 6.6 0.45 10.9 0.2 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF1840) BAF250_C PF12031.8 KOO23059.1 - 0.55 9.5 7.1 1.7 7.9 0.1 3.3 3 1 0 3 3 3 0 SWI/SNF-like complex subunit BAF250/Osa HEAT_EZ PF13513.6 KOO23059.1 - 3.1 8.4 47.6 2.1 9.0 2.4 7.9 3 3 5 8 8 8 0 HEAT-like repeat Questin_oxidase PF14027.6 KOO23059.1 - 9.7 5.6 16.1 0.31 10.5 0.6 3.0 2 1 1 3 3 3 0 Questin oxidase-like Arm PF00514.23 KOO23060.1 - 0.0086 16.1 0.4 7.8 6.7 0.1 2.9 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Chromo PF00385.24 KOO23061.1 - 3.2e-13 49.4 0.9 1.1e-12 47.7 0.9 2.0 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 KOO23061.1 - 0.033 14.3 0.1 0.07 13.3 0.1 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Spectrin PF00435.21 KOO23061.1 - 0.038 14.5 5.9 0.095 13.2 5.6 1.8 1 1 0 1 1 1 0 Spectrin repeat Fe-S_assembly PF04384.13 KOO23061.1 - 0.084 13.5 0.3 0.23 12.1 0.3 1.7 1 0 0 1 1 1 0 Iron-sulphur cluster assembly DUF16 PF01519.16 KOO23061.1 - 0.14 12.7 1.7 0.39 11.2 1.7 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF16 CutC PF03932.14 KOO23061.1 - 0.15 11.6 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 CutC family FERM_M PF00373.18 KOO23062.1 - 1.4e-07 32.0 0.6 3.3e-07 30.7 0.0 1.9 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.10 KOO23062.1 - 0.0035 17.2 0.0 0.011 15.7 0.0 1.8 1 0 0 1 1 1 1 FERM N-terminal domain Rx_N PF18052.1 KOO23062.1 - 0.0039 17.4 0.9 0.011 16.0 0.9 1.7 1 0 0 1 1 1 1 Rx N-terminal domain PRKG1_interact PF15898.5 KOO23062.1 - 0.042 14.7 2.0 0.042 14.7 2.0 2.5 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain MIF4G_like_2 PF09090.11 KOO23062.1 - 0.52 9.7 6.1 0.22 11.0 2.0 2.0 2 0 0 2 2 2 0 MIF4G like DUF4192 PF13830.6 KOO23062.1 - 1.1 9.2 9.3 0.89 9.5 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) YabA PF06156.13 KOO23062.1 - 2 9.1 9.6 0.07 13.8 1.3 2.3 2 0 0 2 2 2 0 Initiation control protein YabA Arm PF00514.23 KOO23065.1 - 1.2e-14 53.7 9.3 0.0061 16.6 0.0 6.8 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO23065.1 - 0.0037 17.6 15.8 0.043 14.2 1.4 3.5 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.22 KOO23065.1 - 0.028 14.6 1.7 1.5 9.3 0.1 3.7 3 0 0 3 3 3 0 HEAT repeat Cnd1 PF12717.7 KOO23065.1 - 0.054 13.5 0.0 9.2 6.3 0.0 2.4 1 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 zf_ZIC PF18366.1 KOO23066.1 - 0.16 12.1 0.1 0.43 10.7 0.1 1.7 1 0 0 1 1 1 0 Zic proteins zinc finger domain Patatin PF01734.22 KOO23067.1 - 5.9e-17 62.5 0.5 1.2e-16 61.5 0.2 1.7 2 0 0 2 2 2 1 Patatin-like phospholipase DUF3336 PF11815.8 KOO23067.1 - 5.9e-12 45.5 0.0 8.7e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Nucleotid_trans PF03407.16 KOO23068.1 - 1.5e-06 28.4 0.2 2.1e-06 27.8 0.2 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase PCuAC PF04314.13 KOO23068.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Copper chaperone PCu(A)C TetR_C_13 PF16925.5 KOO23069.1 - 6.9 6.6 8.5 4.2 7.3 2.0 2.3 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain LptE PF04390.12 KOO23069.1 - 9.1 7.0 8.2 0.24 12.1 0.8 2.3 3 1 0 3 3 3 0 Lipopolysaccharide-assembly LRR_6 PF13516.6 KOO23070.1 - 2.3e-23 80.2 26.8 0.0033 17.4 0.0 10.5 10 0 0 10 10 10 7 Leucine Rich repeat LRR_4 PF12799.7 KOO23070.1 - 4.2e-07 30.2 7.3 2.4 8.7 0.2 6.1 6 1 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO23070.1 - 1.3e-05 25.0 7.4 4.6 8.2 0.0 6.8 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_8 PF13855.6 KOO23070.1 - 0.3 10.9 20.4 3.6 7.4 3.0 6.1 7 2 0 7 7 7 0 Leucine rich repeat DNA_pol_B_thumb PF14791.6 KOO23071.1 - 2.8e-21 75.5 0.0 6.9e-21 74.2 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 KOO23071.1 - 2.3e-18 66.5 0.1 1e-17 64.4 0.1 2.1 2 1 0 2 2 2 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 KOO23071.1 - 3.1e-13 49.3 0.4 1.1e-12 47.5 0.0 2.1 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 KOO23071.1 - 6.5e-11 42.4 0.2 2.2e-08 34.3 0.0 2.7 1 1 1 2 2 2 2 Helix-hairpin-helix domain HHH_5 PF14520.6 KOO23071.1 - 0.0081 16.7 0.1 0.24 12.0 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain DnaB_2 PF07261.11 KOO23071.1 - 0.011 15.5 0.0 0.17 11.7 0.0 2.5 3 0 0 3 3 3 0 Replication initiation and membrane attachment RNA_pol_A_CTD PF03118.15 KOO23071.1 - 0.05 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain HHH_3 PF12836.7 KOO23071.1 - 0.1 12.9 0.1 1.2 9.5 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif Ribosomal_L4 PF00573.22 KOO23072.1 - 7.7e-46 156.2 1.4 9.2e-46 156.0 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family MTS PF05175.14 KOO23073.1 - 1.9e-12 47.1 0.0 7.4e-12 45.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 KOO23073.1 - 5.1e-10 39.2 0.0 8.3e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 KOO23073.1 - 6.1e-08 32.5 0.0 9.7e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 KOO23073.1 - 2.7e-06 28.0 0.1 6.9e-06 26.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 KOO23073.1 - 1.3e-05 25.1 0.0 2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.6 KOO23073.1 - 0.00019 21.3 0.0 0.0015 18.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO23073.1 - 0.00021 21.9 0.4 0.00045 20.8 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain TRM PF02005.16 KOO23073.1 - 0.0003 20.1 0.0 0.00042 19.6 0.0 1.2 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_16 PF10294.9 KOO23073.1 - 0.015 15.0 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_31 PF13847.6 KOO23073.1 - 0.019 14.8 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 KOO23073.1 - 0.029 13.9 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Ion_trans PF00520.31 KOO23074.1 - 1.5e-17 63.7 13.7 6.5e-17 61.6 5.2 2.2 1 1 1 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 KOO23074.1 - 1.3e-07 31.5 5.4 3.5e-07 30.1 5.4 1.7 1 0 0 1 1 1 1 Ion channel Reticulon PF02453.17 KOO23075.1 - 3.5e-09 36.8 4.0 5.3e-09 36.2 0.6 2.1 2 0 0 2 2 2 1 Reticulon AAA_lid_6 PF17866.1 KOO23076.1 - 1.6 8.9 9.0 8.8 6.6 0.6 3.2 3 0 0 3 3 3 0 AAA lid domain Prefoldin_2 PF01920.20 KOO23076.1 - 6 6.9 6.4 10 6.2 2.0 2.8 2 2 0 2 2 2 0 Prefoldin subunit Bmt2 PF11968.8 KOO23077.1 - 1.1e-28 100.7 0.0 1.4e-28 100.3 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 KOO23077.1 - 0.04 13.8 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23077.1 - 0.045 14.5 0.0 0.12 13.1 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain HGTP_anticodon PF03129.20 KOO23078.1 - 2.1e-12 47.0 0.0 4.1e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain Siva PF05458.12 KOO23078.1 - 0.095 12.4 0.2 0.24 11.1 0.1 1.8 2 0 0 2 2 2 0 Cd27 binding protein (Siva) Atx10homo_assoc PF09759.9 KOO23079.1 - 0.01 15.8 0.0 2.7 8.0 0.0 2.5 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain MFMR_assoc PF16596.5 KOO23079.1 - 0.041 14.3 4.1 0.071 13.6 4.1 1.4 1 0 0 1 1 1 0 Disordered region downstream of MFMR Arm PF00514.23 KOO23079.1 - 0.066 13.3 0.1 10 6.3 0.0 3.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Rtf2 PF04641.12 KOO23079.1 - 1 8.7 9.1 1.5 8.1 9.1 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Presenilin PF01080.17 KOO23079.1 - 5.2 5.7 5.4 6.4 5.4 5.4 1.1 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 KOO23080.1 - 5.7e-33 114.4 0.0 9.8e-33 113.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23080.1 - 2.3e-30 105.7 0.0 3.8e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pro_isomerase PF00160.21 KOO23080.1 - 2.6e-18 66.8 0.0 4.9e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD APH PF01636.23 KOO23080.1 - 0.00067 19.7 0.2 0.0032 17.4 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Dpy-30 PF05186.13 KOO23081.1 - 0.00015 21.4 0.0 0.00031 20.4 0.0 1.6 1 0 0 1 1 1 1 Dpy-30 motif APG6_N PF17675.1 KOO23082.1 - 0.83 10.2 6.8 1 9.9 6.8 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4203 PF13886.6 KOO23083.1 - 5.4e-09 36.0 26.3 8.4e-09 35.4 26.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Ebp2 PF05890.12 KOO23084.1 - 6.5e-56 189.8 3.3 7.7e-56 189.6 3.3 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 Endonuc-BsobI PF09194.10 KOO23084.1 - 0.055 12.7 0.1 0.12 11.5 0.0 1.5 2 0 0 2 2 2 0 Restriction endonuclease BsobI LRR_6 PF13516.6 KOO23085.1 - 3.4e-15 54.7 9.9 0.0047 16.9 0.0 6.8 6 0 0 6 6 6 4 Leucine Rich repeat CAF1C_H4-bd PF12265.8 KOO23085.1 - 1.3e-13 50.9 0.1 3.9e-13 49.5 0.0 1.9 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 KOO23085.1 - 2.2e-13 50.4 13.4 0.00035 21.3 0.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat LRR_8 PF13855.6 KOO23085.1 - 0.00021 21.0 3.9 0.36 10.6 0.8 4.6 3 2 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 KOO23085.1 - 0.00051 20.4 1.7 0.38 11.2 0.3 3.8 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO23085.1 - 0.0037 17.6 1.1 24 6.0 0.0 4.9 5 0 0 5 5 5 0 Leucine Rich Repeat ANAPC4_WD40 PF12894.7 KOO23085.1 - 0.0041 17.4 0.7 0.062 13.6 0.5 2.7 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Cwf_Cwc_15 PF04889.12 KOO23085.1 - 0.19 11.4 0.7 0.29 10.8 0.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_E_B PF04042.16 KOO23086.1 - 2.4e-31 108.7 0.4 3.4e-31 108.3 0.4 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.10 KOO23086.1 - 1.8e-05 24.9 0.0 0.00068 19.7 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DUF5538 PF17692.1 KOO23086.1 - 0.26 11.3 5.9 0.19 11.8 0.9 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5538) Cofac_haem_bdg PF04187.13 KOO23087.1 - 4.5e-51 173.9 0.0 5.9e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 Haem-binding uptake, Tiki superfamily, ChaN LRV PF01816.17 KOO23087.1 - 0.36 11.3 0.1 0.36 11.3 0.1 2.6 2 0 0 2 2 2 0 Leucine rich repeat variant YrhC PF14143.6 KOO23088.1 - 0.021 14.9 0.2 0.04 14.0 0.2 1.4 1 0 0 1 1 1 0 YrhC-like protein Voltage_CLC PF00654.20 KOO23091.1 - 4.4e-27 95.2 15.6 6.5e-27 94.7 15.6 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel DUF393 PF04134.12 KOO23093.1 - 4e-16 60.4 0.1 7.6e-16 59.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF393 Virul_fac_BrkB PF03631.15 KOO23094.1 - 0.064 12.9 12.6 0.076 12.6 4.5 2.1 2 0 0 2 2 2 0 Virulence factor BrkB Orthoreo_P10 PF07204.11 KOO23094.1 - 0.089 12.8 0.6 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 Gram_pos_anchor PF00746.21 KOO23094.1 - 0.77 9.8 5.9 1.1 9.2 0.2 2.5 2 0 0 2 2 2 0 LPXTG cell wall anchor motif TCR PF03638.15 KOO23095.1 - 4.1e-23 81.4 50.6 5.7e-12 45.7 20.9 2.5 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 KOO23095.1 - 1.7 8.9 42.7 2 8.6 16.3 2.9 2 0 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 DUF5401 PF17380.2 KOO23096.1 - 0.23 9.5 16.9 0.34 8.9 16.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Peptidase_M29 PF02073.15 KOO23096.1 - 0.41 9.4 3.0 0.53 9.0 3.0 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) Methyltransf_11 PF08241.12 KOO23097.1 - 2e-07 31.5 0.0 4.4e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO23097.1 - 5.7e-06 26.3 0.3 2.1e-05 24.4 0.3 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23097.1 - 7.1e-05 23.5 0.1 0.00024 21.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO23097.1 - 0.0026 18.4 0.1 0.021 15.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO23097.1 - 0.0031 17.3 0.0 0.0053 16.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO23097.1 - 0.036 13.4 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Glyco_trans_2_3 PF13632.6 KOO23098.1 - 3.5e-19 69.5 1.4 5.7e-19 68.8 1.4 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KOO23098.1 - 8.2e-19 68.4 0.0 1.1e-18 68.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 KOO23098.1 - 1.6e-09 37.5 0.0 2.8e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KOO23098.1 - 3.6e-06 26.9 0.0 5.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 AIG1 PF04548.16 KOO23099.1 - 2.9e-08 33.3 0.0 5.6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 KOO23099.1 - 9.8e-08 32.1 0.0 3e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOO23099.1 - 0.00049 20.2 1.5 1 9.4 0.0 2.8 2 1 1 3 3 3 2 Dynamin family IIGP PF05049.13 KOO23099.1 - 0.00084 18.5 0.1 0.002 17.2 0.0 1.5 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 KOO23099.1 - 0.037 13.9 0.0 0.093 12.6 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase Septin PF00735.18 KOO23099.1 - 0.042 13.1 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_29 PF13555.6 KOO23099.1 - 0.064 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Herpes_Helicase PF02689.14 KOO23099.1 - 0.067 11.1 0.0 0.21 9.5 0.0 1.7 2 0 0 2 2 2 0 Helicase DUF4386 PF14329.6 KOO23099.1 - 0.11 12.4 3.0 0.18 11.7 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) AAA_23 PF13476.6 KOO23099.1 - 0.24 11.9 0.1 4.2 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain OmpH PF03938.14 KOO23099.1 - 1.1 9.5 4.9 2.5 8.4 4.9 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HIP1_clath_bdg PF16515.5 KOO23099.1 - 6.2 7.5 10.4 0.65 10.6 5.3 2.0 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AAA PF00004.29 KOO23100.1 - 5.5e-27 94.8 0.0 8.3e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO23100.1 - 0.016 15.6 0.2 0.052 13.9 0.1 1.8 2 0 0 2 2 2 0 AAA ATPase domain DUF2285 PF10074.9 KOO23100.1 - 0.023 15.3 2.0 6.3 7.5 0.1 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2285) AAA_lid_3 PF17862.1 KOO23100.1 - 0.071 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA+ lid domain Synthase_beta PF11421.8 KOO23100.1 - 0.48 11.2 4.0 0.41 11.4 1.0 2.3 2 0 0 2 2 2 0 ATP synthase F1 beta subunit MGDG_synth PF06925.11 KOO23102.1 - 3.2e-23 82.7 0.0 3e-22 79.5 0.0 2.0 1 1 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.16 KOO23102.1 - 1.4e-11 44.6 0.0 2.8e-11 43.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_4 PF13579.6 KOO23102.1 - 0.15 12.5 6.6 2.2 8.7 3.7 3.1 2 1 0 2 2 2 0 Glycosyl transferase 4-like domain Fis1_TPR_C PF14853.6 KOO23103.1 - 9.3e-07 28.8 0.5 9.3e-07 28.8 0.5 1.8 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 KOO23103.1 - 1.7e-05 24.4 0.1 1.7e-05 24.4 0.1 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23103.1 - 3.4e-05 23.6 3.5 6.3e-05 22.8 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23103.1 - 0.0011 19.0 0.0 0.0011 19.0 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23103.1 - 0.0042 17.8 0.1 0.0042 17.8 0.1 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23103.1 - 3.4 7.4 6.0 58 3.5 3.3 3.5 2 1 1 3 3 3 0 TPR repeat Pkinase PF00069.25 KOO23104.1 - 1.4e-25 90.2 0.0 1.5e-18 67.1 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23104.1 - 2e-06 27.3 0.0 3.8e-05 23.1 0.0 2.4 1 1 1 2 2 2 1 Protein tyrosine kinase Tup_N PF08581.10 KOO23104.1 - 0.17 12.2 7.9 3.8 7.9 0.7 2.8 2 0 0 2 2 2 0 Tup N-terminal FA_hydroxylase PF04116.13 KOO23105.1 - 7.9e-22 78.0 18.8 8.9e-22 77.9 15.9 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Beta_helix PF13229.6 KOO23106.1 - 3.5e-97 322.6 35.7 1.4e-19 70.5 1.5 7.0 3 3 4 7 7 7 7 Right handed beta helix region NosD PF05048.13 KOO23106.1 - 6.2e-72 241.8 8.5 1e-15 57.7 2.2 8.1 3 3 5 8 8 8 8 Periplasmic copper-binding protein (NosD) RskA PF10099.9 KOO23107.1 - 0.22 11.8 3.2 0.35 11.1 3.2 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Glycolytic PF00274.19 KOO23108.1 - 3.1e-150 499.8 0.0 3.5e-150 499.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I EMP24_GP25L PF01105.24 KOO23109.1 - 1.2 9.0 7.5 11 6.0 0.6 3.7 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD F_bP_aldolase PF01116.20 KOO23111.1 - 6e-86 288.4 0.0 6.9e-86 288.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Cytidylate_kin2 PF13189.6 KOO23114.1 - 0.99 9.5 8.3 0.27 11.3 2.0 2.3 1 1 0 2 2 2 0 Cytidylate kinase-like family ASFV_J13L PF05568.11 KOO23115.1 - 0.069 12.9 0.3 0.074 12.8 0.3 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein Glyco_transf_8 PF01501.20 KOO23116.1 - 4.6e-14 52.6 0.0 8.6e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 FKBP_C PF00254.28 KOO23117.1 - 2e-25 88.9 0.0 3.8e-25 88.0 0.0 1.4 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase AF-4 PF05110.13 KOO23117.1 - 0.00028 19.2 9.7 0.00033 18.9 9.7 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein SR-25 PF10500.9 KOO23117.1 - 0.0024 17.5 19.9 0.0035 17.0 19.9 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Coilin_N PF15862.5 KOO23117.1 - 0.12 12.2 6.9 0.16 11.8 6.9 1.2 1 0 0 1 1 1 0 Coilin N-terminus Pes-10 PF07149.11 KOO23117.1 - 0.17 10.9 2.3 0.23 10.5 2.3 1.1 1 0 0 1 1 1 0 Pes-10 CCDC106 PF15794.5 KOO23117.1 - 1.1 9.0 15.1 1.4 8.6 15.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Med19 PF10278.9 KOO23117.1 - 1.7 8.5 9.8 2.5 8.0 9.8 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF3381 PF11861.8 KOO23117.1 - 3.9 7.3 11.9 5.1 6.9 11.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Presenilin PF01080.17 KOO23117.1 - 6.3 5.5 8.3 7.2 5.3 8.3 1.1 1 0 0 1 1 1 0 Presenilin Beta_helix PF13229.6 KOO23118.1 - 1.3e-35 122.6 0.0 2.8e-14 53.2 0.0 4.0 3 1 0 4 4 4 3 Right handed beta helix region NosD PF05048.13 KOO23118.1 - 2.5e-16 59.7 0.0 2e-07 30.5 0.0 3.5 3 0 0 3 3 3 3 Periplasmic copper-binding protein (NosD) Cellulase PF00150.18 KOO23119.1 - 0.00014 21.4 0.0 0.00029 20.4 0.0 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Thioredoxin PF00085.20 KOO23120.1 - 3.8e-11 42.9 0.0 1e-09 38.3 0.0 2.3 2 1 0 2 2 2 1 Thioredoxin Arfaptin PF06456.13 KOO23120.1 - 0.00065 19.3 4.1 0.0009 18.9 4.1 1.2 1 0 0 1 1 1 1 Arfaptin-like domain OST3_OST6 PF04756.13 KOO23120.1 - 0.0089 15.4 0.0 0.18 11.1 0.0 2.0 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family DUF1043 PF06295.12 KOO23120.1 - 0.012 15.7 3.5 0.017 15.2 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF4618 PF15397.6 KOO23120.1 - 0.02 14.3 3.6 0.029 13.8 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Thioredoxin_2 PF13098.6 KOO23120.1 - 0.025 15.0 0.0 0.44 11.0 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain MAT1 PF06391.13 KOO23120.1 - 0.11 12.3 4.5 0.14 12.0 4.5 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Tho2 PF11262.8 KOO23120.1 - 0.15 11.3 3.3 0.19 10.9 3.3 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 FapA PF03961.13 KOO23120.1 - 0.19 10.3 1.6 0.23 10.0 1.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A OmpH PF03938.14 KOO23120.1 - 0.23 11.8 7.1 0.35 11.2 7.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HalX PF08663.10 KOO23120.1 - 0.73 10.2 6.3 1.7 9.0 6.3 1.7 1 1 0 1 1 1 0 HalX domain Filamin PF00630.19 KOO23122.1 - 1.1e-21 77.6 0.0 7.6e-07 29.9 0.0 4.9 5 1 0 5 5 5 4 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO23122.1 - 7.3e-05 23.0 0.1 0.00069 19.9 0.0 2.5 2 0 0 2 2 2 1 Invasin, domain 3 EF-hand_6 PF13405.6 KOO23123.1 - 3e-07 29.8 0.1 0.036 14.0 0.1 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO23123.1 - 7.1e-05 23.2 0.1 0.00018 21.9 0.1 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO23123.1 - 0.0002 20.6 0.8 0.059 12.9 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO23123.1 - 0.00042 20.1 0.2 0.0031 17.3 0.1 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO23123.1 - 0.025 14.1 0.6 0.39 10.3 0.3 2.4 2 0 0 2 2 2 0 EF hand GEN1_C PF18380.1 KOO23123.1 - 4.4 8.2 9.1 1.5 9.7 0.8 2.4 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain SNF2_N PF00176.23 KOO23124.1 - 4.8e-61 206.4 0.0 7.9e-61 205.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO23124.1 - 3.9e-18 65.8 0.0 3.3e-17 62.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 KOO23124.1 - 1.5e-07 30.9 0.1 3.1e-07 29.9 0.1 1.5 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 KOO23124.1 - 2.1e-07 31.1 0.0 1.4e-06 28.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOO23124.1 - 0.082 12.1 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase His_Phos_1 PF00300.22 KOO23125.1 - 2.6e-30 105.6 0.0 9.1e-19 67.9 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) 6PF2K PF01591.18 KOO23125.1 - 1.9e-19 69.9 0.0 1.1e-17 64.2 0.0 2.1 2 0 0 2 2 2 2 6-phosphofructo-2-kinase GP46 PF07409.12 KOO23125.1 - 0.1 12.4 0.0 6.9 6.5 0.0 2.3 2 0 0 2 2 2 0 Phage protein GP46 Glyco_trans_1_4 PF13692.6 KOO23126.1 - 7.4e-08 32.9 0.0 2e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 FKBP_C PF00254.28 KOO23127.1 - 1.8e-12 47.4 0.0 3e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF3326 PF11805.8 KOO23128.1 - 1.8e-63 214.5 0.1 2.1e-63 214.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3326) MutS_V PF00488.21 KOO23129.1 - 2.5e-39 135.3 0.0 3.9e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 KOO23129.1 - 3.5e-10 40.1 0.0 7.4e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 MutS domain I GIY-YIG PF01541.24 KOO23129.1 - 0.018 15.3 0.0 0.06 13.6 0.0 1.8 1 1 0 1 1 1 0 GIY-YIG catalytic domain CSD PF00313.22 KOO23130.1 - 3.3e-08 33.2 0.1 7.1e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KOO23130.1 - 0.05 13.3 0.5 0.11 12.2 0.5 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain TFIIA PF03153.13 KOO23131.1 - 1.7e-07 31.6 17.8 3.8e-07 30.5 17.8 1.5 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit TFIIA_gamma_C PF02751.14 KOO23131.1 - 2.2e-05 24.5 0.0 6e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit BUD22 PF09073.10 KOO23131.1 - 0.074 12.4 8.7 0.091 12.1 8.7 1.1 1 0 0 1 1 1 0 BUD22 Pkinase PF00069.25 KOO23132.1 - 4.1e-51 173.9 0.0 5.4e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RCC1 PF00415.18 KOO23132.1 - 1.4e-43 147.3 19.9 1.2e-08 35.5 0.2 9.3 8 1 1 9 9 9 8 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.17 KOO23132.1 - 4.2e-31 108.2 0.1 4.1e-29 101.7 0.1 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase RCC1_2 PF13540.6 KOO23132.1 - 2.7e-23 81.2 39.4 1e-06 28.4 1.4 6.9 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Kinase-like PF14531.6 KOO23132.1 - 0.00013 21.4 0.0 0.00083 18.8 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO23132.1 - 0.006 15.4 0.0 0.0093 14.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO23132.1 - 0.042 13.8 0.3 0.23 11.4 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF2795 PF11387.8 KOO23132.1 - 0.065 13.4 0.1 0.47 10.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) EF-hand_1 PF00036.32 KOO23133.1 - 3.9e-33 110.5 11.6 2.9e-05 23.3 0.0 7.8 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.6 KOO23133.1 - 7.6e-30 103.2 7.3 6.9e-09 36.0 0.1 4.7 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO23133.1 - 7e-28 96.2 8.8 1.9e-10 40.4 0.7 5.9 4 3 3 7 7 7 5 EF-hand domain pair EF-hand_6 PF13405.6 KOO23133.1 - 2.3e-27 92.5 7.1 7.8e-06 25.4 0.0 7.7 7 0 0 7 7 7 6 EF-hand domain EF-hand_5 PF13202.6 KOO23133.1 - 3.2e-21 73.8 6.2 8.7e-06 25.0 0.0 6.9 6 0 0 6 6 6 4 EF hand AKAP28 PF14469.6 KOO23133.1 - 2.7e-09 36.8 0.0 4.6e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 28 kDa A-kinase anchor EF-hand_4 PF12763.7 KOO23133.1 - 3.6e-09 36.5 4.8 0.031 14.2 0.2 5.0 4 1 1 5 5 5 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO23133.1 - 3.9e-08 33.6 1.4 0.017 15.4 0.1 3.6 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO23133.1 - 0.001 18.9 3.8 0.63 9.9 0.1 4.0 4 0 0 4 4 4 1 EF hand TerB PF05099.13 KOO23133.1 - 0.0038 17.2 8.2 0.71 9.8 0.2 3.5 3 1 1 4 4 4 2 Tellurite resistance protein TerB DUF3050 PF11251.8 KOO23133.1 - 0.035 13.7 0.0 0.084 12.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3050) rhaM PF05336.13 KOO23134.1 - 0.0025 17.8 0.0 0.0048 16.9 0.0 1.4 1 0 0 1 1 1 1 L-rhamnose mutarotase Shufflon_N PF04917.12 KOO23137.1 - 0.12 11.8 0.2 0.16 11.4 0.2 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region TGFb_propeptide PF00688.18 KOO23138.1 - 0.00033 20.5 0.9 0.024 14.4 0.2 2.2 2 0 0 2 2 2 2 TGF-beta propeptide NPV_P10 PF05531.12 KOO23139.1 - 0.15 12.6 8.1 5.1 7.6 0.3 3.9 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein zf-C4H2 PF10146.9 KOO23139.1 - 0.6 10.4 18.8 0.27 11.5 13.0 2.4 1 1 2 3 3 3 0 Zinc finger-containing protein Fez1 PF06818.15 KOO23139.1 - 0.72 10.3 34.4 0.52 10.7 7.2 2.6 1 1 1 2 2 2 0 Fez1 FUSC PF04632.12 KOO23139.1 - 1.1 7.7 39.4 1.5 7.3 39.4 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.12 KOO23139.1 - 4.1 7.5 15.5 2 8.5 5.5 3.1 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) MCLC PF05934.11 KOO23139.1 - 9.1 4.9 10.7 19 3.8 10.7 1.5 1 1 0 1 1 1 0 Mid-1-related chloride channel (MCLC) LSDAT_euk PF18139.1 KOO23140.1 - 5.8e-43 147.2 0.0 1.5e-42 145.9 0.0 1.6 2 0 0 2 2 2 1 SLOG in TRPM LSDAT_prok PF18171.1 KOO23140.1 - 1.2e-23 83.4 0.0 2.7e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote NUDIX PF00293.28 KOO23140.1 - 4.3e-14 52.7 0.3 2.5e-09 37.3 0.0 2.9 2 0 0 2 2 2 2 NUDIX domain Ion_trans PF00520.31 KOO23140.1 - 5.1e-05 22.6 0.2 5.1e-05 22.6 0.2 2.1 2 0 0 2 2 2 1 Ion transport protein Dynamitin PF04912.14 KOO23140.1 - 0.011 15.1 2.2 0.03 13.7 0.1 2.4 2 0 0 2 2 2 0 Dynamitin LDcluster4 PF18306.1 KOO23140.1 - 0.16 11.5 0.1 8.5 5.9 0.0 2.9 3 0 0 3 3 3 0 SLOG cluster4 family ABC_tran_CTD PF16326.5 KOO23140.1 - 1.3 9.3 5.7 5 7.4 0.0 3.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain AAA PF00004.29 KOO23141.1 - 4.2e-25 88.7 0.0 3e-12 47.1 0.0 4.7 4 1 0 4 4 4 4 ATPase family associated with various cellular activities (AAA) AAA_lid_6 PF17866.1 KOO23141.1 - 2.4e-14 53.3 6.5 1e-06 28.8 0.5 4.1 3 0 0 3 3 3 3 AAA lid domain AAA_22 PF13401.6 KOO23141.1 - 2.3e-12 47.3 0.0 0.0031 17.8 0.0 5.9 4 2 0 4 4 4 2 AAA domain AAA_5 PF07728.14 KOO23141.1 - 2.6e-05 24.2 0.3 0.3 11.1 0.1 3.4 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOO23141.1 - 7.1e-05 22.3 0.2 0.24 10.8 0.0 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Torsin PF06309.11 KOO23141.1 - 0.00021 21.4 0.0 0.44 10.6 0.0 2.5 2 0 0 2 2 2 2 Torsin Sigma54_activat PF00158.26 KOO23141.1 - 0.00025 20.8 0.2 0.32 10.7 0.1 3.1 3 1 0 3 3 2 2 Sigma-54 interaction domain AAA_30 PF13604.6 KOO23141.1 - 0.00038 20.2 7.0 0.052 13.3 0.2 4.7 5 0 0 5 5 5 2 AAA domain AAA_28 PF13521.6 KOO23141.1 - 0.0006 20.1 4.8 2.8 8.1 0.1 4.5 4 0 0 4 4 4 1 AAA domain AAA_33 PF13671.6 KOO23141.1 - 0.0016 18.6 0.1 0.3 11.2 0.0 3.0 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KOO23141.1 - 0.0019 17.5 0.2 0.12 11.7 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin AAA_19 PF13245.6 KOO23141.1 - 0.0035 17.7 0.1 2.4 8.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain Zot PF05707.12 KOO23141.1 - 0.0037 16.9 0.0 2.2 7.9 0.0 3.8 3 1 1 4 4 4 1 Zonular occludens toxin (Zot) RNA_helicase PF00910.22 KOO23141.1 - 0.015 15.7 0.0 9.3 6.7 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 KOO23141.1 - 0.029 14.1 0.1 4.8 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 KOO23141.1 - 0.035 13.3 1.1 16 4.6 0.0 3.7 3 1 0 4 4 4 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 KOO23141.1 - 0.038 14.5 0.0 2.9 8.4 0.0 3.1 2 0 0 2 2 2 0 AAA domain P5CR_dimer PF14748.6 KOO23141.1 - 0.044 14.0 1.2 0.18 12.1 1.2 2.1 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation NACHT PF05729.12 KOO23141.1 - 0.14 12.1 0.4 11 5.9 0.0 3.3 3 0 0 3 3 3 0 NACHT domain IstB_IS21 PF01695.17 KOO23141.1 - 0.14 11.8 2.0 21 4.8 0.0 3.5 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_16 PF13191.6 KOO23141.1 - 0.14 12.5 12.4 0.29 11.5 0.3 4.8 5 1 0 5 5 3 0 AAA ATPase domain PsiA PF06952.11 KOO23141.1 - 0.15 11.3 0.1 0.29 10.3 0.1 1.4 1 0 0 1 1 1 0 PsiA protein AAA_7 PF12775.7 KOO23141.1 - 0.24 10.9 0.1 24 4.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Ion_trans PF00520.31 KOO23142.1 - 1.2e-164 545.4 30.3 4e-53 180.1 1.2 4.1 3 1 1 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO23142.1 - 0.0063 16.2 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO23142.1 - 0.046 12.4 58.0 0.031 13.0 3.7 8.4 6 2 2 8 8 8 0 Polycystin cation channel Adeno_E3_14_5 PF04834.12 KOO23142.1 - 0.24 11.9 1.2 38 4.9 0.0 3.6 3 0 0 3 3 3 0 Early E3 14.5 kDa protein PAN_2 PF08276.11 KOO23144.1 - 0.0092 16.1 4.7 0.018 15.1 3.9 2.0 2 1 0 2 2 2 1 PAN-like domain PAN_1 PF00024.26 KOO23144.1 - 0.011 15.7 0.1 0.028 14.4 0.2 1.7 2 0 0 2 2 2 0 PAN domain PAN_4 PF14295.6 KOO23144.1 - 0.25 11.3 3.2 0.61 10.0 3.2 1.6 1 0 0 1 1 1 0 PAN domain Chromate_transp PF02417.15 KOO23145.1 - 1e-35 123.2 11.7 1e-35 123.2 11.7 2.5 3 0 0 3 3 3 2 Chromate transporter ClpS PF02617.17 KOO23146.1 - 7.6e-12 44.9 0.0 1.1e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS PAN_1 PF00024.26 KOO23147.1 - 0.048 13.6 0.7 0.1 12.6 0.6 1.7 2 0 0 2 2 2 0 PAN domain PAN_2 PF08276.11 KOO23147.1 - 0.063 13.4 2.6 0.11 12.7 1.6 2.0 2 0 0 2 2 2 0 PAN-like domain CoaE PF01121.20 KOO23148.1 - 3.8e-38 130.9 0.7 1.6e-30 106.1 0.0 2.6 2 0 0 2 2 2 2 Dephospho-CoA kinase CTP_transf_like PF01467.26 KOO23148.1 - 4.8e-06 26.8 0.0 1.6e-05 25.1 0.0 1.9 1 1 0 2 2 2 1 Cytidylyltransferase-like HD PF01966.22 KOO23148.1 - 0.0054 17.0 0.3 0.013 15.8 0.3 1.6 1 0 0 1 1 1 1 HD domain LRR_6 PF13516.6 KOO23149.1 - 3e-09 36.2 19.0 0.29 11.3 0.2 7.1 7 1 0 7 7 7 5 Leucine Rich repeat LRR_1 PF00560.33 KOO23149.1 - 7.3e-06 25.8 1.4 28 5.8 0.0 5.8 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO23149.1 - 4.9e-05 23.0 4.3 8.9 6.2 0.1 5.3 4 1 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 KOO23149.1 - 0.00011 22.5 8.9 0.21 12.1 0.1 4.4 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) AMP-binding PF00501.28 KOO23150.1 - 4.9e-11 41.9 0.0 6.1e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme SH3_2 PF07653.17 KOO23151.1 - 1.5e-12 47.0 0.0 3.2e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOO23151.1 - 2.2e-10 40.2 0.0 4.6e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KOO23151.1 - 1.5e-08 34.1 0.1 3.2e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 SH3 domain MORN PF02493.20 KOO23151.1 - 0.62 10.1 7.9 0.74 9.8 0.4 4.1 3 0 0 3 3 3 0 MORN repeat CBM_20 PF00686.19 KOO23154.1 - 1.7e-11 43.9 0.0 2.1e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Starch binding domain WW PF00397.26 KOO23155.1 - 3.1e-06 27.2 2.6 6.1e-06 26.2 2.6 1.5 1 0 0 1 1 1 1 WW domain ubiquitin PF00240.23 KOO23156.1 - 6.6e-16 57.8 0.0 3.4e-12 45.9 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 KOO23156.1 - 5.1e-07 29.4 0.0 9.6e-05 22.1 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 KOO23156.1 - 0.0063 17.2 0.1 6.6 7.5 0.0 2.7 2 0 0 2 2 2 2 WXG100 protein secretion system (Wss), protein YukD Ank_2 PF12796.7 KOO23158.1 - 1.9e-10 41.2 8.2 2.7e-05 24.7 0.7 4.1 4 1 0 4 4 4 2 Ankyrin repeats (3 copies) LRR_6 PF13516.6 KOO23158.1 - 1.9e-08 33.7 20.4 0.41 10.8 0.1 8.4 9 0 0 9 9 9 3 Leucine Rich repeat Ank_3 PF13606.6 KOO23158.1 - 2.1e-07 30.7 3.8 0.24 12.0 0.0 5.3 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 KOO23158.1 - 9.6e-07 29.2 2.5 0.16 12.6 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) SPRY PF00622.28 KOO23158.1 - 0.0016 18.5 0.0 0.0052 16.9 0.0 1.8 1 1 0 1 1 1 1 SPRY domain Ank PF00023.30 KOO23158.1 - 0.022 15.2 6.4 0.028 14.9 0.0 4.0 5 0 0 5 5 5 0 Ankyrin repeat Ank_5 PF13857.6 KOO23158.1 - 0.12 12.7 8.3 0.24 11.8 0.1 4.4 5 0 0 5 5 5 0 Ankyrin repeats (many copies) LRR_1 PF00560.33 KOO23158.1 - 0.16 12.7 1.4 78 4.4 0.6 4.2 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO23158.1 - 0.17 12.4 0.1 26 5.4 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) STI1 PF17830.1 KOO23159.1 - 4.9e-19 68.0 6.3 9.8e-10 38.2 0.3 3.4 3 2 0 3 3 3 2 STI1 domain DUF3431 PF11913.8 KOO23159.1 - 0.091 12.5 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3431) Ran_BP1 PF00638.18 KOO23160.1 - 8.9e-45 151.9 4.9 1.4e-44 151.3 4.9 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 KOO23160.1 - 0.046 13.7 1.1 0.23 11.4 1.1 1.9 1 1 0 1 1 1 0 WH1 domain Mito_carr PF00153.27 KOO23161.1 - 1.4e-52 175.6 3.1 7.1e-17 61.1 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Ammonium_transp PF00909.21 KOO23161.1 - 0.033 12.9 0.6 0.16 10.6 0.1 2.3 3 0 0 3 3 3 0 Ammonium Transporter Family VirionAssem_T7 PF11653.8 KOO23161.1 - 0.072 13.6 0.0 0.2 12.2 0.0 1.7 1 0 0 1 1 1 0 Bacteriophage T7 virion assembly protein Carboxyl_trans PF01039.22 KOO23162.1 - 4.4e-144 480.8 0.0 3e-143 478.1 0.0 2.0 1 1 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.12 KOO23162.1 - 1.7e-77 261.3 0.0 1.2e-76 258.6 0.0 2.1 1 1 0 1 1 1 1 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.17 KOO23162.1 - 8.5e-47 159.4 0.0 1.8e-46 158.3 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KOO23162.1 - 4.3e-24 85.2 0.0 1.2e-23 83.7 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOO23162.1 - 9.1e-23 80.4 0.0 3e-22 78.7 0.0 2.0 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KOO23162.1 - 9.1e-11 41.4 0.2 2.8e-10 39.9 0.2 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 KOO23162.1 - 0.00034 20.7 0.0 0.00076 19.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 KOO23162.1 - 0.011 15.6 0.0 0.16 11.8 0.0 2.6 2 0 0 2 2 2 0 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 KOO23162.1 - 0.016 14.8 0.0 0.033 13.7 0.0 1.5 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KOO23162.1 - 0.09 12.3 0.0 0.53 9.8 0.0 2.2 1 1 0 1 1 1 0 ATP-grasp domain GCV_H PF01597.19 KOO23162.1 - 0.21 11.5 0.4 4.8 7.1 0.1 2.5 2 0 0 2 2 2 0 Glycine cleavage H-protein MMPL PF03176.15 KOO23163.1 - 2.3e-23 82.7 11.3 4.4e-23 81.7 11.3 1.5 1 0 0 1 1 1 1 MMPL family UQ_con PF00179.26 KOO23164.1 - 1.2e-36 125.4 0.0 1.6e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO23164.1 - 0.09 12.5 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B Hist_deacetyl PF00850.19 KOO23165.1 - 2e-80 270.5 0.2 3.1e-80 269.9 0.2 1.3 1 0 0 1 1 1 1 Histone deacetylase domain MMPL PF03176.15 KOO23166.1 - 5.4e-08 32.1 2.1 6.1e-08 32.0 1.5 1.4 1 1 0 1 1 1 1 MMPL family DUF4705 PF15788.5 KOO23166.1 - 0.044 14.0 1.9 0.077 13.2 1.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4705) PDZ PF00595.24 KOO23167.1 - 1.1e-13 51.3 0.1 8.8e-06 26.0 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KOO23167.1 - 1e-08 35.4 1.7 0.0089 16.3 0.0 3.3 2 1 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KOO23167.1 - 1.2e-07 31.5 4.6 0.04 13.8 0.0 4.1 3 1 1 4 4 4 2 PDZ domain Beta_elim_lyase PF01212.21 KOO23167.1 - 0.0045 16.3 0.1 0.017 14.4 0.1 1.9 1 1 0 1 1 1 1 Beta-eliminating lyase Propeptide_C1 PF08127.13 KOO23167.1 - 0.063 13.2 0.1 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Peptidase family C1 propeptide DUF2538 PF10804.8 KOO23171.1 - 0.042 13.6 0.0 0.045 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2538) TSC21 PF15217.6 KOO23173.1 - 0.021 14.8 0.0 0.023 14.6 0.0 1.0 1 0 0 1 1 1 0 TSC21 family Ank_4 PF13637.6 KOO23176.1 - 1.2e-26 92.7 1.8 1.2e-09 38.5 0.0 5.5 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO23176.1 - 2.5e-22 78.6 4.4 1.4e-07 31.7 0.1 5.0 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO23176.1 - 4e-22 77.6 8.6 0.00021 21.6 0.6 4.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.7 KOO23176.1 - 8e-22 77.6 0.0 5.8e-13 49.2 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO23176.1 - 2.3e-16 58.2 1.6 0.0035 17.7 0.0 5.6 6 0 0 6 6 6 4 Ankyrin repeat MFS_5 PF05631.14 KOO23177.1 - 4.1e-73 246.3 2.9 5.6e-73 245.9 2.9 1.1 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 KOO23177.1 - 3.6e-09 36.0 34.1 1.5e-08 34.0 24.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CDC50 PF03381.15 KOO23178.1 - 6.5e-62 209.6 0.0 1.3e-61 208.6 0.0 1.5 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF3899 PF13038.6 KOO23178.1 - 0.078 13.5 1.1 1.5 9.4 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DUF2157 PF09925.9 KOO23178.1 - 0.23 11.2 1.0 15 5.3 0.0 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) SelR PF01641.18 KOO23179.1 - 1.4e-32 112.3 0.0 1.9e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 SelR domain MOZ_SAS PF01853.18 KOO23180.1 - 7.9e-73 243.9 0.0 9.9e-73 243.6 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KOO23180.1 - 1.6e-20 72.4 0.6 3.9e-20 71.2 0.6 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 KOO23180.1 - 3e-05 24.3 0.0 5.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO23180.1 - 0.00082 19.6 0.0 0.0015 18.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 KOO23180.1 - 0.028 14.4 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_10 PF13673.7 KOO23180.1 - 0.04 13.9 0.0 0.065 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain IF2_N PF04760.15 KOO23180.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region DnaJ-X PF14308.6 KOO23181.1 - 1.2e-28 100.0 0.1 3.3e-28 98.6 0.0 1.7 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 KOO23181.1 - 2.3e-24 85.3 1.8 4.2e-24 84.4 1.8 1.5 1 0 0 1 1 1 1 DnaJ domain ATG_C PF09333.11 KOO23181.1 - 0.00019 21.7 0.6 0.00089 19.6 0.0 2.4 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain PRK PF00485.18 KOO23182.1 - 3.7e-08 33.3 0.0 3.6e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family DUF2594 PF10769.9 KOO23182.1 - 0.21 11.7 0.0 0.48 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2594) LRR_6 PF13516.6 KOO23183.1 - 7.8e-37 122.2 81.7 0.0022 17.9 0.1 28.4 32 0 0 32 32 32 10 Leucine Rich repeat LRR_1 PF00560.33 KOO23183.1 - 8.8e-14 49.9 4.3 53 5.0 0.2 15.9 21 0 0 21 21 17 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO23183.1 - 1.9e-11 44.0 33.5 0.87 10.1 0.0 14.9 12 4 4 16 16 16 3 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.12 KOO23183.1 - 1.1e-05 25.6 3.5 76 3.7 0.0 8.4 8 1 1 9 9 9 0 RNA 2'-O ribose methyltransferase substrate binding Metal_CEHH PF14455.6 KOO23183.1 - 2e-05 24.3 1.3 0.013 15.1 0.0 3.9 3 1 1 4 4 4 1 Predicted metal binding domain LRR_8 PF13855.6 KOO23183.1 - 0.00013 21.7 28.2 1 9.2 0.1 13.2 15 7 1 16 16 16 2 Leucine rich repeat FIBP PF05427.11 KOO23183.1 - 0.078 12.3 0.0 11 5.1 0.0 2.3 2 0 0 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) DUF2202 PF09968.9 KOO23183.1 - 0.086 12.7 0.7 1.3e+02 2.4 0.0 4.0 4 0 0 4 4 4 0 Uncharacterized protein domain (DUF2202) TbpB_B_D PF01298.18 KOO23183.1 - 0.37 11.2 2.6 7.4 7.0 0.2 2.9 2 0 0 2 2 2 0 C-lobe and N-lobe beta barrels of Tf-binding protein B Arm-DNA-bind_1 PF09003.10 KOO23183.1 - 0.5 10.5 4.0 1.7e+02 2.4 0.0 4.9 4 0 0 4 4 4 0 Bacteriophage lambda integrase, Arm DNA-binding domain PAD_M PF08527.10 KOO23183.1 - 0.99 9.0 3.0 1.6e+02 1.9 0.1 4.0 4 0 0 4 4 4 0 Protein-arginine deiminase (PAD) middle domain EF-hand_1 PF00036.32 KOO23184.1 - 7.2e-11 40.8 0.2 0.00025 20.4 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO23184.1 - 1.5e-07 30.8 0.4 0.0077 16.1 0.1 3.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 KOO23184.1 - 2.4e-07 31.1 1.1 9.8e-07 29.1 0.7 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO23184.1 - 0.0047 16.4 0.3 0.18 11.4 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO23184.1 - 0.0067 16.2 4.0 0.073 12.9 0.3 3.5 3 2 1 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO23184.1 - 0.022 15.1 0.4 0.052 13.9 0.3 1.7 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region NIPSNAP PF07978.13 KOO23185.1 - 5.1e-14 52.3 0.1 3.3e-07 30.4 0.0 2.2 2 0 0 2 2 2 2 NIPSNAP DIOX_N PF14226.6 KOO23186.1 - 0.11 13.2 0.0 0.15 12.8 0.0 1.2 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal Molybdopterin PF00384.22 KOO23187.1 - 0.11 11.4 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin oxidoreductase SASA PF03629.18 KOO23188.1 - 2.8e-13 50.1 0.0 8.1e-08 32.2 0.0 2.5 2 1 0 2 2 2 2 Carbohydrate esterase, sialic acid-specific acetylesterase PQ-loop PF04193.14 KOO23188.1 - 5.5e-12 45.3 6.4 5.3e-06 26.1 0.2 3.0 3 0 0 3 3 3 2 PQ loop repeat ADH_zinc_N_2 PF13602.6 KOO23189.1 - 9.6e-16 59.0 0.0 1.9e-15 58.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOO23189.1 - 4.9e-13 49.2 0.3 1.6e-12 47.5 0.1 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOO23189.1 - 0.0001 21.9 0.3 0.00019 21.0 0.1 1.4 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus ADH_N PF08240.12 KOO23189.1 - 0.0076 16.1 1.9 0.017 15.0 1.8 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain zf-RING_7 PF02591.15 KOO23189.1 - 0.059 13.6 0.4 0.12 12.6 0.4 1.5 1 0 0 1 1 1 0 C4-type zinc ribbon domain TPR_1 PF00515.28 KOO23190.1 - 3.6e-12 45.5 7.4 6.9e-06 25.7 0.2 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23190.1 - 1.4e-11 43.6 5.9 0.00038 20.4 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23190.1 - 3.2e-10 39.3 0.2 0.00062 19.6 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23190.1 - 9.3e-09 35.5 0.4 2.2e-08 34.3 0.3 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23190.1 - 4.6e-08 32.7 0.3 0.017 15.3 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO23190.1 - 3.2e-05 23.6 1.2 0.013 15.3 0.9 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO23190.1 - 0.0055 17.3 0.8 0.86 10.4 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23190.1 - 0.05 13.3 1.6 1.7 8.4 0.2 2.9 2 1 0 2 2 2 0 TPR repeat TPR_3 PF07720.12 KOO23190.1 - 0.067 13.2 0.4 0.87 9.6 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 KOO23190.1 - 0.085 12.9 0.6 9 6.4 0.1 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 KOO23190.1 - 0.17 12.8 4.3 8.8 7.4 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23190.1 - 0.25 11.9 3.2 12 6.5 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23190.1 - 0.36 11.5 11.1 0.34 11.6 0.9 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat LRR_4 PF12799.7 KOO23191.1 - 1.2e-12 47.8 19.7 0.0011 19.3 0.0 5.6 2 2 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO23191.1 - 1.8e-11 43.6 23.2 8.3e-05 22.3 2.2 4.8 2 2 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 KOO23191.1 - 0.0053 17.1 11.5 2.9 8.8 0.1 6.2 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_6 PF13516.6 KOO23191.1 - 2.2 8.5 13.9 10 6.5 0.0 6.5 8 0 0 8 8 8 0 Leucine Rich repeat AAA_2 PF07724.14 KOO23192.1 - 8.2e-43 146.5 1.5 1.9e-34 119.2 0.2 2.7 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 KOO23192.1 - 1.5e-15 57.8 1.0 1.3e-06 28.8 0.1 2.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO23192.1 - 1.2e-06 28.6 0.2 3.8e-05 23.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 KOO23192.1 - 1.4e-05 25.1 0.4 1.4e-05 25.1 0.4 2.1 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_22 PF13401.6 KOO23192.1 - 2.8e-05 24.4 1.1 0.00025 21.3 0.0 2.8 2 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KOO23192.1 - 6.4e-05 23.4 1.1 0.0014 19.0 1.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 KOO23192.1 - 6.8e-05 23.1 0.1 0.00019 21.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 KOO23192.1 - 0.00087 19.8 0.1 0.0031 18.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 KOO23192.1 - 0.0017 17.8 0.0 0.0071 15.8 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KOO23192.1 - 0.0034 17.1 0.3 0.056 13.2 0.0 2.6 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_3 PF07726.11 KOO23192.1 - 0.0038 17.1 0.3 3.3 7.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 KOO23192.1 - 0.0094 15.7 0.0 0.032 14.0 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein RuvB_N PF05496.12 KOO23192.1 - 0.016 14.9 3.0 0.63 9.8 0.0 3.4 3 1 1 4 4 4 0 Holliday junction DNA helicase RuvB P-loop domain RsgA_GTPase PF03193.16 KOO23192.1 - 0.019 14.8 0.9 6.6 6.6 0.0 2.9 2 1 1 3 3 3 0 RsgA GTPase NACHT PF05729.12 KOO23192.1 - 0.027 14.4 0.2 2.3 8.1 0.0 2.6 3 0 0 3 3 2 0 NACHT domain AAA_28 PF13521.6 KOO23192.1 - 0.028 14.7 0.0 0.068 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 KOO23192.1 - 0.032 13.9 0.1 0.098 12.3 0.1 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain IPT PF01745.16 KOO23192.1 - 0.034 13.5 0.3 0.24 10.7 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase AAA_24 PF13479.6 KOO23192.1 - 0.043 13.5 0.1 0.08 12.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 KOO23192.1 - 0.056 12.8 0.4 0.17 11.2 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 KOO23192.1 - 0.059 12.9 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Roc PF08477.13 KOO23192.1 - 0.11 12.8 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DEAD PF00270.29 KOO23192.1 - 0.18 11.6 3.0 1.7 8.4 3.0 2.8 1 1 0 1 1 1 0 DEAD/DEAH box helicase FAD_binding_3 PF01494.19 KOO23193.1 - 9.9e-20 71.1 0.0 7.5e-19 68.2 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KOO23193.1 - 2.5e-05 24.4 0.1 5.4e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO23193.1 - 0.00056 19.1 0.1 0.0012 18.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 KOO23193.1 - 0.0025 17.1 0.3 0.013 14.8 0.1 2.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 KOO23193.1 - 0.0043 16.2 0.0 0.0063 15.6 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase DAO PF01266.24 KOO23193.1 - 0.0049 16.5 0.5 0.33 10.5 0.0 2.5 2 1 0 3 3 3 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 KOO23193.1 - 0.057 12.7 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 KOO23193.1 - 0.13 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase EF-hand_1 PF00036.32 KOO23194.1 - 5.1e-33 110.1 15.8 8.4e-09 34.4 0.8 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO23194.1 - 2.6e-31 107.9 10.1 8.3e-16 58.2 1.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23194.1 - 6e-27 91.2 10.1 1.1e-09 37.4 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO23194.1 - 1.3e-24 85.8 15.4 1e-11 44.5 0.9 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO23194.1 - 3.5e-18 64.2 15.7 2e-05 23.8 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KOO23194.1 - 4.9e-15 55.6 0.6 1.4e-07 31.7 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO23194.1 - 2.3e-07 30.7 7.9 0.058 13.4 0.8 3.5 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 KOO23194.1 - 0.00012 22.4 1.5 0.033 14.5 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain SurA_N_3 PF13624.6 KOO23194.1 - 0.0017 18.2 0.5 1.3 8.8 0.0 2.1 1 1 1 2 2 2 2 SurA N-terminal domain Dockerin_1 PF00404.18 KOO23194.1 - 0.011 15.9 2.9 0.062 13.5 0.2 2.4 2 1 0 2 2 2 0 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KOO23194.1 - 0.014 15.7 0.2 2.9 8.3 0.1 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 KOO23194.1 - 0.015 15.2 1.5 4.3 7.3 0.3 3.1 1 1 2 3 3 3 0 Tellurite resistance protein TerB Caleosin PF05042.13 KOO23194.1 - 0.023 14.6 0.4 3.1 7.7 0.0 3.0 1 1 2 3 3 3 0 Caleosin related protein SUB1_ProdP9 PF18213.1 KOO23194.1 - 0.038 13.8 0.2 0.083 12.7 0.2 1.5 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 DUF3008 PF11450.8 KOO23194.1 - 0.043 14.0 2.3 0.25 11.6 0.1 2.4 2 0 0 2 2 2 0 Protein of unknwon function (DUF3008) Skp1 PF01466.19 KOO23194.1 - 0.12 12.5 2.0 2.2 8.4 0.1 2.9 3 0 0 3 3 3 0 Skp1 family, dimerisation domain SPK PF04435.18 KOO23194.1 - 0.12 12.8 0.0 10 6.6 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF545) SurA_N_2 PF13623.6 KOO23194.1 - 0.22 11.4 1.0 1.7 8.5 0.3 2.3 1 1 1 2 2 2 0 SurA N-terminal domain DegQ PF08181.11 KOO23195.1 - 0.14 12.3 0.3 0.34 11.0 0.3 1.6 1 0 0 1 1 1 0 DegQ (SacQ) family E2F_CC-MB PF16421.5 KOO23195.1 - 1 9.8 3.5 3.2 8.2 0.0 3.2 3 1 0 3 3 3 0 E2F transcription factor CC-MB domain PAP_fibrillin PF04755.12 KOO23196.1 - 0.00072 19.5 0.2 0.16 11.9 0.0 2.9 3 0 0 3 3 3 2 PAP_fibrillin Nucleotid_trans PF03407.16 KOO23197.1 - 1.3e-58 198.5 0.0 5.7e-38 131.0 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-diphospho-sugar transferase Tower PF09121.10 KOO23197.1 - 0.29 11.4 0.8 3.6 7.9 0.1 2.3 2 0 0 2 2 2 0 Tower O-FucT PF10250.9 KOO23199.1 - 1.3e-07 31.7 0.0 1e-06 28.7 0.0 2.0 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase PKcGMP_CC PF16808.5 KOO23199.1 - 0.025 14.4 1.4 0.048 13.5 1.4 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase She9_MDM33 PF05546.11 KOO23199.1 - 0.12 12.2 0.5 0.22 11.3 0.5 1.3 1 0 0 1 1 1 0 She9 / Mdm33 family RRM_1 PF00076.22 KOO23201.1 - 0.026 14.3 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOO23201.1 - 0.089 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PhyH PF05721.13 KOO23202.1 - 4.4e-23 82.7 0.0 6.6e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Tnp_DNA_bind PF14706.6 KOO23202.1 - 0.039 13.8 0.7 0.11 12.4 0.1 2.1 2 0 0 2 2 2 0 Transposase DNA-binding EMC3_TMCO1 PF01956.16 KOO23203.1 - 1.1e-27 96.8 13.3 1.1e-27 96.8 13.3 1.5 1 1 1 2 2 2 1 Integral membrane protein EMC3/TMCO1-like Laminin_G_3 PF13385.6 KOO23205.1 - 1.6e-16 60.8 0.1 2.2e-16 60.4 0.1 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tymo_coat PF00983.18 KOO23205.1 - 0.014 15.2 0.1 0.026 14.3 0.1 1.3 1 0 0 1 1 1 0 Tymovirus coat protein zf-piccolo PF05715.13 KOO23206.1 - 0.16 12.1 3.5 0.23 11.6 0.4 2.7 2 1 0 2 2 2 0 Piccolo Zn-finger EF-hand_8 PF13833.6 KOO23207.1 - 2.3e-09 37.0 0.4 4.3e-05 23.3 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO23207.1 - 5.4e-09 36.4 0.7 1.5e-08 34.9 0.7 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO23207.1 - 2.1e-08 33.1 1.0 0.0058 16.1 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO23207.1 - 1.1e-06 27.9 1.0 0.0092 15.4 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO23207.1 - 2.1e-06 27.2 0.5 0.0031 17.3 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain DUF1007 PF06226.13 KOO23207.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1007) AA_permease_2 PF13520.6 KOO23208.1 - 6.9e-31 107.5 21.7 8.5e-31 107.2 21.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOO23208.1 - 1e-16 60.6 18.4 1.5e-16 60.0 18.4 1.2 1 0 0 1 1 1 1 Amino acid permease Phosphodiest PF01663.22 KOO23209.1 - 4.6e-11 42.9 0.0 5.6e-06 26.2 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KOO23209.1 - 0.0023 17.4 0.0 0.0046 16.4 0.0 1.6 1 1 0 1 1 1 1 Sulfatase EF-hand_1 PF00036.32 KOO23210.1 - 1.9e-22 77.1 1.0 2.3e-05 23.6 0.0 6.2 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.6 KOO23210.1 - 5e-22 78.1 4.3 2e-07 31.3 0.0 4.2 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO23210.1 - 5.1e-22 75.9 9.5 2e-05 24.2 0.1 6.7 6 1 1 7 7 7 4 EF-hand domain EF-hand_5 PF13202.6 KOO23210.1 - 6.2e-16 57.1 6.7 0.0013 18.1 0.0 6.3 5 1 1 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO23210.1 - 9.4e-08 31.8 0.0 0.38 10.6 0.0 4.9 4 0 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO23210.1 - 0.00039 20.7 0.0 0.96 9.8 0.0 3.4 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO23210.1 - 0.031 14.1 1.0 20 5.1 0.1 3.5 3 0 0 3 3 3 0 EF hand Caleosin PF05042.13 KOO23210.1 - 0.11 12.4 0.1 62 3.5 0.0 4.2 5 1 1 6 6 6 0 Caleosin related protein CysA_C_terminal PF17850.1 KOO23210.1 - 0.12 13.0 0.2 11 6.7 0.0 3.1 2 0 0 2 2 2 0 CysA C-terminal regulatory domain DUF1018 PF06252.12 KOO23210.1 - 0.49 11.4 5.7 2.6 9.1 0.4 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1018) EF-hand_6 PF13405.6 KOO23211.1 - 1.7e-08 33.7 0.6 1.8e-07 30.6 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO23211.1 - 1.9e-08 33.3 0.8 2.1e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO23211.1 - 3.9e-07 29.3 1.4 0.00023 20.5 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO23211.1 - 6.5e-07 29.7 0.0 1e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO23211.1 - 0.00061 19.6 0.7 0.0092 15.8 0.1 2.3 1 1 1 2 2 2 1 EF-hand domain pair DEC-1_N PF04625.13 KOO23211.1 - 0.3 10.0 4.2 0.46 9.5 4.2 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Peptidase_C2 PF00648.21 KOO23213.1 - 6e-20 71.4 0.0 9.1e-20 70.9 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Med3 PF11593.8 KOO23214.1 - 0.026 13.7 8.0 0.035 13.3 8.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF844 PF05815.11 KOO23214.1 - 0.53 9.4 3.9 0.29 10.3 1.0 1.8 1 1 1 2 2 2 0 Baculovirus protein of unknown function (DUF844) HhH-GPD PF00730.25 KOO23215.1 - 3.3e-14 53.2 0.0 7e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KOO23215.1 - 1.8e-05 24.4 0.2 0.00023 20.8 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 KOO23215.1 - 0.068 13.8 0.0 0.83 10.3 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain MAGE_N PF12440.8 KOO23215.1 - 8 7.2 16.5 0.43 11.3 10.0 2.1 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal 7tm_1 PF00001.21 KOO23216.1 - 0.00097 18.5 1.9 0.0011 18.4 1.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) EI24 PF07264.11 KOO23216.1 - 0.0011 19.3 6.0 0.0013 19.0 6.0 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) MIG-14_Wnt-bd PF06664.12 KOO23216.1 - 0.0051 16.1 2.4 0.0073 15.6 2.4 1.3 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion FtsL PF04999.13 KOO23216.1 - 0.42 10.6 0.2 0.42 10.6 0.2 2.3 3 0 0 3 3 3 0 Cell division protein FtsL ERO1 PF04137.15 KOO23217.1 - 3.4e-46 158.1 0.0 5.4e-45 154.1 0.0 2.0 1 1 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) B PF02216.16 KOO23217.1 - 0.2 11.7 0.0 0.37 10.8 0.0 1.4 1 0 0 1 1 1 0 B domain YbaB_DNA_bd PF02575.16 KOO23218.1 - 2e-11 44.0 5.1 2.7e-11 43.5 5.1 1.1 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family DUF2007 PF09413.10 KOO23218.1 - 0.052 13.7 0.2 0.089 13.0 0.2 1.3 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein TGBp3 PF02495.17 KOO23218.1 - 0.17 11.5 1.6 0.22 11.2 0.1 1.8 2 0 0 2 2 2 0 Triple gene block 3 EF-hand_7 PF13499.6 KOO23219.1 - 2.1e-19 69.7 12.9 5.5e-11 42.8 1.7 4.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO23219.1 - 3.5e-19 67.0 17.9 2.6e-05 23.8 0.5 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 KOO23219.1 - 6.8e-17 60.1 10.3 1.4e-05 24.3 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_1 PF00036.32 KOO23219.1 - 1.5e-16 58.6 21.3 6.1e-05 22.3 0.0 5.4 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO23219.1 - 1e-12 47.7 12.6 0.0015 18.3 0.0 4.7 4 1 1 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO23219.1 - 1.4e-05 25.3 0.7 0.037 14.3 0.0 2.9 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO23219.1 - 0.0042 16.9 1.9 0.56 10.1 0.2 3.1 2 1 1 3 3 3 1 EF hand PARP PF00644.20 KOO23219.1 - 0.0073 15.9 0.1 0.012 15.2 0.1 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Sec16_N PF12935.7 KOO23219.1 - 0.024 14.8 7.1 0.74 9.9 0.8 2.2 1 1 0 2 2 2 0 Vesicle coat trafficking protein Sec16 N-terminus LRR_5 PF13306.6 KOO23220.1 - 1.8e-70 234.8 0.0 2.5e-36 124.4 0.0 2.1 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO23220.1 - 2.3e-14 52.9 0.0 0.00048 19.8 0.0 5.7 2 1 4 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 KOO23220.1 - 0.25 11.8 3.3 2.2e+02 2.5 0.1 5.6 4 3 2 6 6 6 0 Leucine Rich repeats (2 copies) EF-hand_7 PF13499.6 KOO23221.1 - 4.2e-11 43.1 0.5 5.8e-08 33.1 0.0 2.8 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO23221.1 - 3.1e-07 29.5 1.6 0.0064 16.0 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KOO23221.1 - 1.4e-05 24.3 2.6 0.0033 16.8 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO23221.1 - 3.7e-05 23.5 0.2 0.34 10.8 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23221.1 - 0.00025 20.7 0.8 0.09 12.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain Aldo_ket_red PF00248.21 KOO23222.1 - 6.4e-14 51.8 0.0 5.2e-12 45.6 0.0 2.3 1 1 0 1 1 1 1 Aldo/keto reductase family TSC22 PF01166.18 KOO23222.1 - 0.48 10.8 4.5 3.5 8.0 0.6 2.4 2 0 0 2 2 2 0 TSC-22/dip/bun family JIP_LZII PF16471.5 KOO23222.1 - 1.2 9.3 6.9 2.8 8.2 6.9 1.6 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II Guanylate_cyc PF00211.20 KOO23223.1 - 2.2e-22 79.6 0.3 1e-09 38.3 0.2 2.8 2 1 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.6 KOO23223.1 - 2.6e-08 34.4 0.2 2.6e-08 34.4 0.2 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOO23223.1 - 0.00015 22.0 0.4 0.0042 17.3 0.4 2.7 1 1 0 1 1 1 1 AAA domain TPR_2 PF07719.17 KOO23223.1 - 0.001 19.0 12.7 0.29 11.4 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat ABC_tran PF00005.27 KOO23223.1 - 0.015 15.8 0.0 0.039 14.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter ANAPC3 PF12895.7 KOO23223.1 - 0.085 13.1 1.2 0.76 10.1 0.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TsaE PF02367.17 KOO23223.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 KOO23223.1 - 0.11 12.5 0.0 0.33 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 KOO23223.1 - 0.13 11.5 0.0 0.78 8.9 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_19 PF13245.6 KOO23223.1 - 0.18 12.1 5.6 4.2 7.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain TPR_19 PF14559.6 KOO23223.1 - 0.27 11.8 8.1 4.9 7.7 0.9 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO23223.1 - 0.59 10.9 12.4 2.1 9.2 0.1 5.9 5 0 0 5 5 3 0 Tetratricopeptide repeat Myb_DNA-binding PF00249.31 KOO23224.1 - 7.2e-27 93.3 6.5 7.1e-15 54.9 0.9 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO23224.1 - 3.4e-22 78.5 9.0 6e-17 61.7 1.4 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO23224.1 - 0.00066 19.5 1.3 0.0048 16.8 0.6 2.1 1 1 1 2 2 2 1 Myb DNA-binding like SLIDE PF09111.10 KOO23224.1 - 0.0019 18.2 0.2 0.032 14.3 0.0 2.2 1 1 0 2 2 2 1 SLIDE SANT_DAMP1_like PF16282.5 KOO23224.1 - 0.005 17.0 3.2 0.11 12.7 1.0 2.2 1 1 1 2 2 2 1 SANT/Myb-like domain of DAMP1 MADF_DNA_bdg PF10545.9 KOO23224.1 - 0.06 13.7 6.2 1 9.8 1.0 2.4 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 KOO23224.1 - 1.8 9.0 6.4 5.3 7.5 0.6 2.4 1 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF1825 PF08855.10 KOO23225.1 - 2.4e-13 49.9 0.1 1.5e-12 47.3 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1825) SAM_Exu PF18609.1 KOO23225.1 - 0.12 12.5 0.7 4.9 7.3 0.1 2.8 3 0 0 3 3 3 0 Exuperantia SAM-like domain TPR_12 PF13424.6 KOO23226.1 - 5.7e-11 42.6 16.5 4.9e-07 29.9 2.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23226.1 - 1.5e-06 28.7 19.0 0.062 14.0 8.0 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23226.1 - 0.00067 19.5 5.8 0.12 12.5 0.1 3.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23226.1 - 0.0014 19.3 16.0 0.78 10.7 0.2 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23226.1 - 0.004 17.2 16.5 0.11 12.7 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23226.1 - 0.01 16.0 10.6 0.24 11.7 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO23226.1 - 0.022 14.6 0.0 0.022 14.6 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF1598 PF07643.11 KOO23226.1 - 0.17 12.1 1.0 0.53 10.6 0.1 2.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1598) TPR_19 PF14559.6 KOO23226.1 - 0.36 11.4 18.7 3.5 8.2 0.8 4.2 1 1 2 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO23226.1 - 2.4 9.0 15.4 0.53 11.0 0.4 4.6 4 2 0 4 4 4 0 Tetratricopeptide repeat CcdA PF07362.12 KOO23226.1 - 2.6 8.5 6.1 18 5.8 0.2 2.7 2 0 0 2 2 2 0 Post-segregation antitoxin CcdA Ion_trans_2 PF07885.16 KOO23227.1 - 1.4e-15 57.0 8.5 4.5e-13 49.0 2.3 2.4 2 0 0 2 2 2 2 Ion channel NYN PF01936.18 KOO23227.1 - 2.8e-05 24.6 0.0 6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 NYN domain EF-hand_1 PF00036.32 KOO23227.1 - 0.0013 18.1 9.4 0.0025 17.2 0.1 3.6 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 KOO23227.1 - 0.0019 18.6 1.6 0.073 13.5 0.5 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23227.1 - 0.016 15.1 0.0 0.016 15.1 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain EF-hand_5 PF13202.6 KOO23227.1 - 0.096 12.2 6.6 0.47 10.0 0.0 3.5 3 0 0 3 3 3 0 EF hand Ion_trans PF00520.31 KOO23227.1 - 0.18 11.0 7.6 1.8 7.7 7.5 2.1 1 1 1 2 2 2 0 Ion transport protein Angiomotin_C PF12240.8 KOO23227.1 - 0.24 11.0 0.1 0.24 11.0 0.1 1.5 2 0 0 2 2 2 0 Angiomotin C terminal ELO PF01151.18 KOO23228.1 - 1e-46 159.5 4.2 1.3e-46 159.2 4.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family PAN_1 PF00024.26 KOO23229.1 - 0.0026 17.7 1.8 0.0047 16.9 1.8 1.4 1 0 0 1 1 1 1 PAN domain CBM_2 PF00553.19 KOO23231.1 - 0.021 15.1 0.0 0.025 14.9 0.0 1.1 1 0 0 1 1 1 0 Cellulose binding domain YchF-GTPase_C PF06071.13 KOO23232.1 - 3.9e-39 132.7 0.2 1.2e-38 131.2 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 KOO23232.1 - 4.4e-24 84.8 0.1 1.1e-23 83.4 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOO23232.1 - 4.7e-08 32.7 0.3 2.1e-07 30.6 0.0 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOO23232.1 - 0.017 15.2 0.3 7.9 6.5 0.1 3.0 1 1 1 3 3 3 0 Dynamin family RsgA_GTPase PF03193.16 KOO23232.1 - 0.039 13.9 0.1 3.2 7.6 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase DUF1471 PF07338.13 KOO23232.1 - 0.57 10.2 2.4 0.82 9.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) DHR10 PF18595.1 KOO23232.1 - 2.9 8.0 7.8 0.55 10.3 2.2 2.3 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain EF-hand_7 PF13499.6 KOO23233.1 - 1.5e-05 25.3 0.1 2.6e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO23233.1 - 9.6e-05 21.7 0.1 0.055 13.0 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO23233.1 - 0.00016 21.0 0.1 0.025 14.1 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO23233.1 - 0.002 17.9 0.0 1.4 9.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO23233.1 - 0.0087 15.9 0.1 0.023 14.5 0.1 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO23233.1 - 0.16 12.3 0.1 0.29 11.5 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain Kinesin PF00225.23 KOO23234.1 - 1.5e-98 329.8 0.0 2.6e-98 329.0 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO23234.1 - 6.1e-17 61.9 0.0 1.3e-16 60.8 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding PARP PF00644.20 KOO23234.1 - 9.9e-13 48.1 0.0 3.1e-12 46.5 0.0 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain RPW8 PF05659.11 KOO23234.1 - 0.24 11.1 4.5 2.1 8.0 1.7 2.8 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 AAA_22 PF13401.6 KOO23234.1 - 2.7 8.3 5.0 9.3 6.5 0.0 3.3 4 0 0 4 4 4 0 AAA domain YlqD PF11068.8 KOO23234.1 - 8 6.8 21.8 0.63 10.4 0.2 3.8 3 1 1 4 4 4 0 YlqD protein MAT1 PF06391.13 KOO23234.1 - 9.2 6.0 20.8 14 5.4 2.6 2.8 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 AstE_AspA PF04952.14 KOO23235.1 - 1.5e-44 152.3 0.0 1.8e-44 152.0 0.0 1.0 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Peptidase_M99 PF17033.5 KOO23235.1 - 0.025 14.0 0.0 0.063 12.7 0.0 1.6 1 1 1 2 2 2 0 Carboxypeptidase controlling helical cell shape catalytic DUF4267 PF14087.6 KOO23237.1 - 0.043 13.9 0.0 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4267) EF-hand_7 PF13499.6 KOO23238.1 - 1.1e-10 41.8 0.2 0.0094 16.4 0.0 5.0 4 2 1 5 5 5 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO23238.1 - 4.2e-07 29.0 0.1 0.12 11.9 0.0 5.2 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.6 KOO23238.1 - 7.6e-07 28.6 2.6 0.034 14.1 0.0 5.5 5 0 0 5 5 5 2 EF-hand domain EF-hand_5 PF13202.6 KOO23238.1 - 0.00089 18.7 4.3 0.74 9.4 0.1 4.0 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO23238.1 - 0.0032 17.3 0.4 27 4.7 0.1 4.9 5 0 0 5 5 5 0 EF-hand domain pair SCA7 PF08313.12 KOO23238.1 - 0.02 14.8 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 SCA7, zinc-binding domain SPARC_Ca_bdg PF10591.9 KOO23238.1 - 0.024 14.9 0.1 3.2 8.1 0.0 2.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3350 PF11830.8 KOO23238.1 - 0.24 11.7 2.0 0.88 9.9 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3350) NHL PF01436.21 KOO23239.1 - 1.6e-05 24.7 0.1 0.01 15.8 0.0 3.4 3 0 0 3 3 3 1 NHL repeat DUF5128 PF17170.4 KOO23239.1 - 0.0026 17.0 0.0 0.0034 16.6 0.0 1.2 1 0 0 1 1 1 1 6-bladed beta-propeller DUF4934 PF16288.5 KOO23239.1 - 0.21 11.5 0.0 0.3 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4934) Aa_trans PF01490.18 KOO23241.1 - 1e-49 169.4 12.2 1.2e-49 169.2 12.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOO23241.1 - 4.9e-06 25.9 13.4 2e-05 23.8 13.4 1.9 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family Yippee-Mis18 PF03226.14 KOO23241.1 - 0.16 12.2 0.0 0.28 11.4 0.0 1.3 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PI-PLC-X PF00388.19 KOO23242.1 - 3e-48 163.1 0.0 1.5e-47 160.8 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain NADH-u_ox-rdase PF10785.9 KOO23242.1 - 0.066 13.9 0.3 0.3 11.8 0.1 2.2 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit PI-PLC-Y PF00387.19 KOO23243.1 - 1.5e-13 51.1 0.0 2.7e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 KOO23243.1 - 0.036 14.4 0.0 0.065 13.5 0.0 1.4 1 0 0 1 1 1 0 C2 domain Fumble PF03630.14 KOO23244.1 - 2.1e-87 293.4 0.0 2.5e-87 293.2 0.0 1.0 1 0 0 1 1 1 1 Fumble RETICULATA-like PF11891.8 KOO23245.1 - 2.5e-35 121.9 0.2 2.9e-35 121.7 0.2 1.0 1 0 0 1 1 1 1 Protein RETICULATA-related Orai-1 PF07856.12 KOO23247.1 - 5.2e-06 26.2 8.6 4.4e-05 23.3 8.6 2.0 1 1 0 1 1 1 1 Mediator of CRAC channel activity DUF3487 PF11990.8 KOO23247.1 - 4.5 7.2 5.3 10 6.0 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) AAA_16 PF13191.6 KOO23248.1 - 0.00098 19.5 0.6 0.0017 18.8 0.6 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 KOO23248.1 - 0.05 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 KOO23248.1 - 0.056 13.1 0.0 0.094 12.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF4440 PF14534.6 KOO23249.1 - 6.9e-06 26.4 0.4 0.11 13.0 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 KOO23249.1 - 0.0033 17.7 0.0 1 9.6 0.0 2.4 2 0 0 2 2 2 2 SnoaL-like domain CaMKII_AD PF08332.10 KOO23249.1 - 0.009 16.2 0.0 3.5 7.8 0.0 2.5 2 0 0 2 2 2 2 Calcium/calmodulin dependent protein kinase II association domain OB_NTP_bind PF07717.16 KOO23249.1 - 0.02 15.2 0.0 0.83 10.1 0.0 2.2 2 0 0 2 2 2 0 Oligonucleotide/oligosaccharide-binding (OB)-fold SnoaL_2 PF12680.7 KOO23249.1 - 0.041 14.5 2.9 2.2 9.0 0.6 2.8 2 1 1 3 3 3 0 SnoaL-like domain Proteasom_Rpn13 PF04683.13 KOO23252.1 - 2.2e-17 63.4 0.0 3.3e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 KOO23252.1 - 2.4e-10 40.6 0.1 3.7e-10 40.0 0.1 1.3 1 0 0 1 1 1 1 UCH-binding domain ATP-grasp_4 PF13535.6 KOO23253.1 - 1.3e-07 31.3 0.0 3.1e-07 30.1 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 KOO23253.1 - 4.9e-06 26.7 0.0 7.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 KOO23253.1 - 0.0027 17.4 0.0 0.014 15.1 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.19 KOO23253.1 - 0.017 14.9 0.0 0.054 13.3 0.0 1.8 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain 2_5_RNA_ligase2 PF13563.6 KOO23254.1 - 5.5e-06 26.4 0.3 0.046 13.6 0.1 2.9 1 1 2 3 3 3 2 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 KOO23254.1 - 0.0003 20.9 0.0 0.66 10.2 0.0 2.5 2 0 0 2 2 2 2 LigT like Phosphoesterase EF-hand_7 PF13499.6 KOO23257.1 - 5.3e-12 46.0 2.4 1.5e-06 28.6 0.2 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO23257.1 - 1.4e-09 37.6 0.4 8.9e-05 22.3 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO23257.1 - 9.1e-08 31.1 4.4 0.11 12.1 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KOO23257.1 - 1.5e-07 31.6 0.1 3.4e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 KOO23257.1 - 3.5e-07 29.6 5.4 0.098 12.6 1.8 4.7 3 1 1 4 4 4 3 EF-hand domain DUF3967 PF13152.6 KOO23257.1 - 0.039 13.7 0.2 0.41 10.5 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3967) PK PF00224.21 KOO23258.1 - 1.3e-101 340.0 0.0 1.6e-101 339.7 0.0 1.0 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain HpcH_HpaI PF03328.14 KOO23258.1 - 0.018 14.2 0.1 0.047 12.8 0.1 1.7 1 1 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 KOO23258.1 - 0.071 12.1 0.5 0.68 8.9 0.0 2.4 3 0 0 3 3 3 0 IMP dehydrogenase / GMP reductase domain Ank_2 PF12796.7 KOO23259.1 - 5.5e-17 62.1 1.0 2.6e-10 40.7 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO23259.1 - 8.2e-15 55.0 1.0 4.9e-06 27.0 0.2 3.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO23259.1 - 1.1e-14 53.0 0.0 0.0045 17.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO23259.1 - 6.6e-13 48.5 1.2 0.00013 22.2 0.0 3.8 3 1 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KOO23259.1 - 2.3e-11 43.7 0.0 0.00014 22.0 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Mur_ligase PF01225.25 KOO23259.1 - 0.021 15.1 0.0 15 6.0 0.0 2.7 2 1 0 3 3 3 0 Mur ligase family, catalytic domain Pkinase PF00069.25 KOO23260.1 - 4.1e-24 85.4 0.0 1.3e-23 83.7 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain PARP PF00644.20 KOO23260.1 - 1e-15 57.9 0.0 2.2e-15 56.8 0.0 1.5 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase_Tyr PF07714.17 KOO23260.1 - 1.5e-10 40.8 0.0 4e-10 39.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Motile_Sperm PF00635.26 KOO23260.1 - 1.2e-06 28.3 0.0 0.032 14.1 0.0 2.3 2 0 0 2 2 2 2 MSP (Major sperm protein) domain Kdo PF06293.14 KOO23260.1 - 2.3e-06 27.1 0.0 5.8e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Dynamin_N PF00350.23 KOO23261.1 - 1.8e-18 67.2 0.0 2.8e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Dynamin family Arm PF00514.23 KOO23261.1 - 1.6e-10 40.6 1.0 2.5e-05 24.2 0.2 3.0 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat U-box PF04564.15 KOO23261.1 - 0.00035 20.7 0.0 0.00098 19.3 0.0 1.8 1 0 0 1 1 1 1 U-box domain MMR_HSR1 PF01926.23 KOO23261.1 - 0.0012 18.9 0.0 0.009 16.1 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase HEAT_EZ PF13513.6 KOO23261.1 - 0.0025 18.3 10.4 0.0086 16.6 1.3 3.9 3 1 1 4 4 4 2 HEAT-like repeat zf-NOSIP PF15906.5 KOO23261.1 - 0.017 15.3 0.2 0.13 12.5 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein HEAT PF02985.22 KOO23261.1 - 0.087 13.1 0.0 0.087 13.1 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat Maf_N PF08383.11 KOO23261.1 - 5.2 6.9 5.6 62 3.5 0.0 4.7 5 1 0 5 5 5 0 Maf N-terminal region TauD PF02668.16 KOO23262.1 - 0.00027 20.9 0.0 0.00027 20.9 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family ABC_tran_CTD PF16326.5 KOO23263.1 - 0.016 15.5 0.8 10 6.5 0.0 3.5 3 1 0 3 3 3 0 ABC transporter C-terminal domain zf-MIZ PF02891.20 KOO23263.1 - 0.028 14.2 0.7 4.4 7.1 0.1 2.6 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger DUF4763 PF15960.5 KOO23263.1 - 0.031 13.6 0.6 3.2 7.0 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Lzipper-MIP1 PF14389.6 KOO23263.1 - 2.2 8.6 7.1 9.2 6.6 0.1 3.8 3 2 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 SMC_N PF02463.19 KOO23264.1 - 1.3e-16 60.7 0.0 3.4e-11 43.0 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOO23264.1 - 8.9e-05 22.4 0.0 0.0001 22.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO23265.1 - 2.5e-18 66.3 0.0 3.4e-18 65.9 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOO23265.1 - 1.9e-08 35.1 0.0 2.2e-08 34.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 KOO23265.1 - 0.00014 21.5 0.0 0.00024 20.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.12 KOO23265.1 - 0.0046 16.9 0.0 0.016 15.2 0.0 1.9 1 0 0 1 1 1 1 NACHT domain ABC_tran PF00005.27 KOO23265.1 - 0.021 15.3 0.0 0.061 13.8 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 KOO23265.1 - 0.023 15.0 2.7 0.27 11.5 0.4 2.9 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 KOO23265.1 - 0.038 13.7 0.0 0.053 13.2 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain DUF4427 PF14468.6 KOO23265.1 - 0.052 13.6 0.3 0.099 12.7 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4427) AAA_21 PF13304.6 KOO23265.1 - 0.07 12.9 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 KOO23265.1 - 0.11 12.6 3.0 0.19 11.9 0.1 2.5 2 2 0 2 2 2 0 AAA domain Hint PF01079.20 KOO23266.1 - 8e-19 68.0 0.1 1.1e-18 67.6 0.1 1.1 1 0 0 1 1 1 1 Hint module Pestivirus_E2 PF16329.5 KOO23266.1 - 0.049 12.5 0.0 0.072 11.9 0.0 1.2 1 0 0 1 1 1 0 Pestivirus envelope glycoprotein E2 Peptidase_M8 PF01457.16 KOO23267.1 - 1.4e-48 165.9 0.2 5.3e-44 150.8 0.2 3.1 2 1 0 2 2 2 2 Leishmanolysin PKD_channel PF08016.12 KOO23268.1 - 5.2e-28 97.9 14.7 1.2e-26 93.4 15.8 2.1 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 KOO23268.1 - 9.9e-11 41.3 17.5 9.9e-11 41.3 17.5 2.4 2 1 0 2 2 2 1 Ion transport protein SMI1_KNR4 PF09346.10 KOO23269.1 - 1.8e-12 47.8 0.0 2.2e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) SUKH_6 PF14568.6 KOO23269.1 - 0.026 15.0 0.0 0.078 13.4 0.0 1.8 1 1 0 1 1 1 0 SMI1-KNR4 cell-wall ART PF01129.18 KOO23271.1 - 1.2e-07 31.2 0.0 2.3e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO23271.1 - 0.00051 19.4 0.0 0.001 18.5 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Tachylectin PF14517.6 KOO23271.1 - 0.087 12.4 0.3 0.14 11.6 0.3 1.2 1 0 0 1 1 1 0 Tachylectin TPR_1 PF00515.28 KOO23273.1 - 4.4e-18 64.3 8.5 5.8e-09 35.4 0.1 3.9 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23273.1 - 4.4e-16 57.6 6.2 3.4e-08 33.0 0.1 3.7 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23273.1 - 2e-09 36.9 2.5 0.0021 17.7 0.1 3.6 2 1 1 3 3 3 3 TPR repeat TPR_6 PF13174.6 KOO23273.1 - 2.6e-09 37.1 2.5 1.5e-05 25.3 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23273.1 - 3.5e-09 37.0 2.0 1.9e-06 28.2 0.6 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23273.1 - 1.7e-08 34.0 7.2 4.8e-06 26.4 0.0 3.8 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO23273.1 - 2.5e-08 33.7 1.0 4.8e-06 26.6 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23273.1 - 2.5e-08 34.4 1.8 0.00032 21.3 0.1 2.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23273.1 - 5.8e-08 32.9 1.0 1.3e-05 25.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO23273.1 - 1.9e-07 31.1 0.6 8.5e-07 29.0 0.2 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23273.1 - 3.4e-05 24.3 2.0 0.0028 18.3 0.2 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO23273.1 - 0.0014 18.7 0.4 1.1 9.4 0.0 2.5 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 KOO23273.1 - 0.0023 17.9 2.5 0.97 9.6 0.1 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TolA_bind_tri PF16331.5 KOO23273.1 - 0.02 15.0 0.1 0.041 14.0 0.1 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation TPR_15 PF13429.6 KOO23273.1 - 0.044 13.0 0.0 0.071 12.3 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF982 PF06169.12 KOO23273.1 - 0.055 13.5 0.0 0.15 12.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF982) TPR_10 PF13374.6 KOO23273.1 - 0.15 12.0 1.4 0.85 9.6 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat FKBP_C PF00254.28 KOO23274.1 - 1.4e-20 73.4 0.0 3.6e-20 72.1 0.0 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 KOO23274.1 - 1.9e-06 28.7 0.0 4.3e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase SAP PF02037.27 KOO23274.1 - 0.00044 19.9 0.1 0.00082 19.1 0.1 1.5 1 0 0 1 1 1 1 SAP domain LRR_8 PF13855.6 KOO23275.1 - 1.7e-33 114.1 20.4 1.7e-08 34.1 0.8 6.1 5 1 1 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 KOO23275.1 - 2.6e-25 88.0 18.4 9e-06 26.0 1.6 7.3 7 0 0 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO23275.1 - 5.2e-10 38.5 20.2 1.1 10.1 0.1 11.0 10 2 0 10 10 10 3 Leucine Rich Repeat PSII_BNR PF14870.6 KOO23275.1 - 6.1e-05 22.4 0.7 0.85 8.8 0.0 3.7 3 1 1 4 4 4 2 Photosynthesis system II assembly factor YCF48 LRR_9 PF14580.6 KOO23275.1 - 0.077 12.5 4.0 16 5.0 0.0 3.1 1 1 1 3 3 3 0 Leucine-rich repeat Sortilin-Vps10 PF15902.5 KOO23275.1 - 0.14 10.9 0.0 0.24 10.1 0.0 1.3 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, FMN_dh PF01070.18 KOO23277.1 - 6.4e-120 400.3 0.0 8e-120 400.0 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 KOO23277.1 - 0.00022 20.5 0.6 0.00037 19.8 0.6 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 KOO23277.1 - 0.00024 20.2 0.4 0.0004 19.5 0.4 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 KOO23277.1 - 0.011 15.1 2.1 0.011 15.1 2.1 1.5 2 0 0 2 2 2 0 Nitronate monooxygenase DHO_dh PF01180.21 KOO23277.1 - 0.081 12.1 0.1 0.22 10.7 0.1 1.6 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase ThiG PF05690.14 KOO23277.1 - 0.12 11.7 0.1 3.1 7.0 0.1 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 KOO23277.1 - 0.15 11.5 0.0 0.38 10.2 0.0 1.6 1 1 1 2 2 2 0 Histidine biosynthesis protein ZF-HD_dimer PF04770.12 KOO23277.1 - 0.26 11.6 4.5 6.8 7.1 0.9 2.4 2 0 0 2 2 2 0 ZF-HD protein dimerisation region ATG16 PF08614.11 KOO23278.1 - 0.31 11.2 17.3 0.02 15.1 9.5 2.3 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) OmpH PF03938.14 KOO23278.1 - 3 8.2 14.1 24 5.3 13.2 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) APG6_N PF17675.1 KOO23278.1 - 3.5 8.1 20.4 0.4 11.2 13.0 2.5 2 1 0 2 2 2 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 KOO23278.1 - 4 7.7 13.6 2.8 8.2 8.9 2.9 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Glycos_transf_1 PF00534.20 KOO23279.1 - 9.1e-33 113.2 0.0 2e-32 112.1 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOO23279.1 - 9.5e-29 100.5 0.1 2.4e-28 99.2 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOO23279.1 - 2.4e-21 76.5 0.0 1.3e-20 74.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 KOO23279.1 - 6.5e-14 52.7 0.0 2.4e-13 50.9 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 KOO23279.1 - 1.6e-11 44.5 0.0 4.1e-11 43.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 KOO23279.1 - 0.002 18.2 0.0 0.0033 17.4 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase 4-like ATP_synt_H PF05493.13 KOO23280.1 - 1.6e-19 70.1 10.4 1.9e-19 69.9 10.4 1.0 1 0 0 1 1 1 1 ATP synthase subunit H OST3_OST6 PF04756.13 KOO23280.1 - 0.1 12.0 1.1 0.11 11.8 1.1 1.0 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family DUF1664 PF07889.12 KOO23282.1 - 4.4 7.4 30.6 1.4 8.9 1.8 4.8 3 1 3 6 6 6 0 Protein of unknown function (DUF1664) UPF0047 PF01894.17 KOO23283.1 - 9.6e-12 45.1 0.0 0.00012 22.2 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised protein family UPF0047 EF-hand_6 PF13405.6 KOO23284.1 - 3.7e-35 116.8 15.8 1.1e-05 24.9 0.1 8.3 8 0 0 8 8 8 6 EF-hand domain EF-hand_1 PF00036.32 KOO23284.1 - 3.9e-35 116.8 13.4 8.9e-07 28.0 1.0 8.3 8 0 0 8 8 8 6 EF hand EF-hand_7 PF13499.6 KOO23284.1 - 6.9e-33 112.9 10.7 9.7e-11 42.0 0.3 4.3 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO23284.1 - 4.1e-22 77.8 7.3 5.1e-07 29.4 0.2 5.5 4 1 1 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO23284.1 - 3.4e-21 73.7 27.4 4.6e-05 22.7 0.1 7.7 8 0 0 8 8 8 6 EF hand SPARC_Ca_bdg PF10591.9 KOO23284.1 - 5.4e-08 33.2 0.1 0.0053 17.1 0.0 4.2 4 1 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO23284.1 - 0.00075 20.3 0.0 1.6 9.7 0.0 4.1 3 2 1 4 4 4 1 EF-hand domain DUF440 PF04269.12 KOO23284.1 - 0.011 16.0 0.4 0.051 13.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF440 Caleosin PF05042.13 KOO23284.1 - 0.038 13.9 1.0 64 3.4 0.0 4.7 4 3 3 7 7 7 0 Caleosin related protein DUF1707 PF08044.11 KOO23284.1 - 0.19 11.8 4.0 17 5.6 0.6 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1707) cNMP_binding PF00027.29 KOO23285.1 - 8.5e-16 57.8 0.1 5e-08 32.9 0.1 4.1 4 1 0 4 4 4 3 Cyclic nucleotide-binding domain Helicase_C PF00271.31 KOO23287.1 - 9.5e-26 90.3 0.0 1.6e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO23287.1 - 6.5e-10 39.1 0.0 1.1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase EF-hand_1 PF00036.32 KOO23288.1 - 1.7e-06 27.1 0.1 0.013 15.0 0.0 3.1 2 1 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO23288.1 - 0.00017 21.0 0.1 0.15 11.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO23288.1 - 0.00034 20.3 0.2 0.62 10.2 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO23288.1 - 0.006 17.0 0.0 0.024 15.1 0.0 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO23288.1 - 0.0087 15.9 0.1 0.087 12.7 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair LEH PF07858.12 KOO23288.1 - 0.04 14.0 0.6 0.1 12.7 0.4 1.8 1 1 1 2 2 2 0 Limonene-1,2-epoxide hydrolase catalytic domain PrmA PF06325.13 KOO23289.1 - 7.8e-11 41.9 0.0 1.2e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KOO23289.1 - 2e-09 38.0 0.0 6.4e-09 36.4 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO23289.1 - 1.2e-07 32.3 0.0 2.8e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO23289.1 - 8.6e-07 28.7 0.0 1.6e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 KOO23289.1 - 2.4e-06 27.0 0.3 6.8e-06 25.6 0.0 1.7 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.6 KOO23289.1 - 3.6e-06 26.8 0.0 5.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO23289.1 - 0.00012 21.9 0.0 0.00018 21.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 KOO23289.1 - 0.00019 21.4 0.0 0.00029 20.7 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Met_10 PF02475.16 KOO23289.1 - 0.00026 20.8 0.1 0.00039 20.2 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 KOO23289.1 - 0.00028 20.6 0.1 0.00047 19.8 0.1 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.7 KOO23289.1 - 0.00043 20.2 0.0 0.00085 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23289.1 - 0.00046 20.9 0.0 0.00098 19.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 KOO23289.1 - 0.00093 18.7 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_24 PF13578.6 KOO23289.1 - 0.0056 17.7 0.0 0.011 16.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO23289.1 - 0.0082 15.9 0.2 0.013 15.3 0.2 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 KOO23289.1 - 0.014 14.8 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PRMT5_C PF17286.2 KOO23289.1 - 0.028 14.3 0.0 0.069 13.0 0.0 1.4 1 1 0 1 1 1 0 PRMT5 oligomerisation domain Methyltransf_9 PF08003.11 KOO23289.1 - 0.042 12.8 0.0 0.081 11.8 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) NNMT_PNMT_TEMT PF01234.17 KOO23289.1 - 0.063 12.5 0.0 8.1 5.6 0.0 2.1 1 1 1 2 2 2 0 NNMT/PNMT/TEMT family GCD14 PF08704.10 KOO23289.1 - 0.11 12.2 0.1 0.35 10.5 0.0 1.7 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit PDZ PF00595.24 KOO23290.1 - 1.3e-25 89.6 3.2 3.4e-06 27.3 0.2 4.3 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 KOO23290.1 - 1e-19 70.1 6.2 4.6e-05 23.2 0.0 4.5 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 KOO23290.1 - 1.2e-07 32.0 1.8 0.21 11.9 0.0 4.4 4 0 0 4 4 4 2 PDZ domain UIM PF02809.20 KOO23290.1 - 0.00043 20.0 11.5 0.063 13.2 2.3 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif EccE PF11203.8 KOO23290.1 - 6.1 7.2 7.2 3.7 7.9 2.4 2.6 1 1 1 2 2 2 0 Putative type VII ESX secretion system translocon, EccE zf-NADH-PPase PF09297.11 KOO23291.1 - 2.9 7.6 13.9 0.23 11.1 5.5 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Alpha_kinase PF02816.18 KOO23292.1 - 1.7e-45 155.4 0.0 2.1e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Alpha-kinase family KN17_SH3 PF18131.1 KOO23292.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 KN17 SH3-like C-terminal domain DEAD PF00270.29 KOO23293.1 - 2e-18 66.8 0.0 7.3e-17 61.7 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO23293.1 - 1.9e-15 57.2 0.0 5.6e-15 55.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO23293.1 - 1.9e-11 44.3 0.0 3.5e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit dsrm PF00035.26 KOO23293.1 - 0.0016 19.1 0.1 0.0071 17.0 0.1 2.1 2 0 0 2 2 2 1 Double-stranded RNA binding motif FliT PF05400.13 KOO23293.1 - 0.19 12.6 0.9 0.68 10.8 0.9 2.0 1 0 0 1 1 1 0 Flagellar protein FliT PAS_9 PF13426.7 KOO23294.1 - 1.2e-08 35.2 0.0 2e-08 34.4 0.0 1.4 1 1 0 1 1 1 1 PAS domain PAS PF00989.25 KOO23294.1 - 4.8e-06 26.5 0.0 9.8e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 PAS fold PAS_4 PF08448.10 KOO23294.1 - 0.00078 19.7 0.1 0.0038 17.5 0.1 1.9 1 1 0 1 1 1 1 PAS fold PAS_8 PF13188.7 KOO23294.1 - 0.0019 18.2 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 PAS domain Laminin_G_3 PF13385.6 KOO23295.1 - 1.5e-09 38.2 0.0 7.1e-08 32.7 0.0 2.9 1 1 2 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Peptidase_M16 PF00675.20 KOO23295.1 - 0.001 19.1 0.1 0.002 18.1 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) YabA PF06156.13 KOO23296.1 - 0.077 13.6 0.6 0.26 11.9 0.1 1.9 1 1 1 2 2 2 0 Initiation control protein YabA Spectrin PF00435.21 KOO23297.1 - 0.0023 18.4 0.6 0.0028 18.1 0.6 1.2 1 0 0 1 1 1 1 Spectrin repeat CHIP_TPR_N PF18391.1 KOO23297.1 - 0.0088 16.8 1.0 0.089 13.6 1.0 2.1 1 1 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain ABC_tran_CTD PF16326.5 KOO23297.1 - 0.0092 16.2 4.1 0.016 15.5 0.8 2.2 2 0 0 2 2 2 1 ABC transporter C-terminal domain Baculo_PEP_C PF04513.12 KOO23297.1 - 0.1 12.7 0.2 0.12 12.4 0.2 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIC PF04977.15 KOO23297.1 - 0.12 12.1 0.4 0.98 9.2 0.1 2.1 1 1 1 2 2 2 0 Septum formation initiator DUF3684 PF12449.8 KOO23298.1 - 7.1e-17 60.5 0.0 5.2e-08 31.2 0.0 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF3684) HATPase_c PF02518.26 KOO23298.1 - 0.00012 22.5 0.0 0.00029 21.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOO23298.1 - 0.00021 21.1 0.0 0.00037 20.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ank_4 PF13637.6 KOO23299.1 - 0.0063 17.1 0.1 0.19 12.4 0.1 2.9 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO23299.1 - 0.15 12.7 0.3 2.7 8.8 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 KOO23299.1 - 0.16 12.5 0.1 0.85 10.3 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) EMP24_GP25L PF01105.24 KOO23300.1 - 4.2e-33 114.8 0.0 4.9e-33 114.6 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 KOO23300.1 - 0.0067 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 SdrD B-like domain Pro_isomerase PF00160.21 KOO23301.1 - 3.8e-21 76.0 0.0 6e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TetR_C_21 PF17926.1 KOO23301.1 - 0.013 15.6 0.2 0.025 14.7 0.2 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain IMS PF00817.20 KOO23302.1 - 1.5e-35 122.4 0.2 2e-35 122.0 0.2 1.2 1 0 0 1 1 1 1 impB/mucB/samB family IMS_HHH PF11798.8 KOO23302.1 - 0.0069 16.7 0.0 0.016 15.5 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif Cdd1 PF11731.8 KOO23302.1 - 0.1 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Pathogenicity locus Methyltransf_21 PF05050.12 KOO23303.1 - 6.4e-09 36.1 0.0 1.4e-08 35.0 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase FkbM domain Nup54 PF13874.6 KOO23303.1 - 0.13 12.4 0.2 0.26 11.4 0.0 1.6 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 SlyX PF04102.12 KOO23304.1 - 0.0083 16.7 0.3 0.024 15.3 0.3 1.8 1 0 0 1 1 1 1 SlyX RRN3 PF05327.11 KOO23304.1 - 2.3 6.6 3.3 3 6.3 3.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 KOO23304.1 - 5.8 5.0 9.0 7.3 4.7 9.0 1.1 1 0 0 1 1 1 0 Nop14-like family Methyltransf_32 PF13679.6 KOO23305.1 - 5.1e-28 98.1 0.2 1.1e-27 97.0 0.2 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO23305.1 - 1.6e-06 28.0 0.1 3.4e-06 26.9 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain TRM13 PF05206.14 KOO23305.1 - 0.00032 20.3 1.3 0.38 10.2 0.2 3.7 4 0 0 4 4 4 2 Methyltransferase TRM13 Methyltransf_25 PF13649.6 KOO23305.1 - 0.0041 17.8 0.2 0.017 15.8 0.1 2.1 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 KOO23305.1 - 0.15 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TMEM131_like PF12371.8 KOO23306.1 - 2.5e-16 59.7 3.0 5.2e-16 58.7 0.1 3.2 4 0 0 4 4 4 1 Transmembrane protein 131-like ASH PF15780.5 KOO23306.1 - 0.00034 20.7 0.0 0.039 14.2 0.0 3.7 4 0 0 4 4 4 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Selenoprotein_S PF06936.11 KOO23306.1 - 7.2 6.4 12.4 14 5.4 12.4 1.5 1 0 0 1 1 1 0 Selenoprotein S (SelS) FH2 PF02181.23 KOO23308.1 - 3.1e-48 164.8 0.0 1.3e-31 110.0 0.0 3.5 2 2 0 2 2 2 2 Formin Homology 2 Domain Proteasome PF00227.26 KOO23309.1 - 9e-60 201.4 0.0 1.1e-59 201.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit KGG PF10685.9 KOO23309.1 - 1.9 8.9 4.2 4.4 7.7 4.2 1.6 1 0 0 1 1 1 0 Stress-induced bacterial acidophilic repeat motif DHHC PF01529.20 KOO23310.1 - 3.8e-13 49.7 6.1 3.8e-13 49.7 6.1 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase DSPc PF00782.20 KOO23312.1 - 1.1e-09 38.2 0.0 1.5e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KOO23312.1 - 6e-07 29.7 0.0 7.5e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 KOO23312.1 - 0.0035 17.0 0.0 0.0043 16.7 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KOO23312.1 - 0.031 14.2 0.0 0.038 14.0 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Man-6-P_recep PF02157.15 KOO23315.1 - 3.3e-10 39.5 0.2 5e-10 38.9 0.2 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 KOO23315.1 - 6e-06 26.3 0.0 7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 27 APG6_N PF17675.1 KOO23316.1 - 0.0005 20.6 19.1 0.0005 20.6 19.1 7.8 3 2 4 7 7 7 4 Apg6 coiled-coil region DnaJ PF00226.31 KOO23317.1 - 5.7e-28 96.8 1.1 1e-27 96.0 1.1 1.4 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 KOO23317.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 A repeated domain in UCH-protein LRR_6 PF13516.6 KOO23318.1 - 4.4e-10 38.8 7.8 0.16 12.1 0.6 8.1 9 0 0 9 9 9 2 Leucine Rich repeat PAS PF00989.25 KOO23318.1 - 0.0058 16.6 0.0 0.019 14.9 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 KOO23318.1 - 0.049 13.9 0.1 0.35 11.1 0.0 2.6 2 1 0 2 2 2 0 PAS fold PDZ_6 PF17820.1 KOO23319.1 - 2.4e-28 97.7 0.6 2.8e-10 39.9 0.0 3.6 3 0 0 3 3 3 3 PDZ domain PDZ PF00595.24 KOO23319.1 - 1.7e-18 66.8 0.0 1e-05 25.8 0.0 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KOO23319.1 - 5.9e-18 65.0 0.3 7.6e-05 23.0 0.0 3.4 3 0 0 3 3 3 3 PDZ domain EF-hand_1 PF00036.32 KOO23319.1 - 6.1e-12 44.2 0.8 2.5e-05 23.5 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO23319.1 - 1.7e-09 36.8 0.4 0.00016 21.3 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO23319.1 - 1.9e-08 34.6 0.2 3.6e-08 33.7 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO23319.1 - 3e-07 30.2 0.3 2.6e-05 24.0 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO23319.1 - 7.6e-07 28.4 2.2 0.0024 17.3 0.5 2.4 2 0 0 2 2 2 2 EF hand Tricorn_PDZ PF14685.6 KOO23319.1 - 7.3e-06 25.9 0.1 1.3 9.1 0.0 3.5 3 0 0 3 3 3 3 Tricorn protease PDZ domain EF-hand_11 PF08976.11 KOO23319.1 - 0.00035 21.4 0.1 0.0013 19.6 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain DUF1918 PF08940.11 KOO23319.1 - 0.1 12.2 0.0 0.29 10.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) TPR_10 PF13374.6 KOO23320.1 - 3.8e-62 204.6 17.7 2.7e-11 43.0 0.5 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23320.1 - 1e-54 182.7 14.7 2.5e-18 66.1 3.6 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23320.1 - 3.2e-27 93.2 13.8 8e-06 25.5 0.4 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23320.1 - 2e-23 80.5 17.0 0.00011 22.0 0.7 7.0 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO23320.1 - 4.7e-23 82.1 5.8 3e-13 49.9 1.8 2.4 1 1 1 2 2 2 2 MalT-like TPR region TPR_8 PF13181.6 KOO23320.1 - 1.3e-21 74.9 7.5 0.00015 21.7 0.2 6.8 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23320.1 - 6.7e-21 72.7 14.4 0.00017 21.4 0.1 6.0 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23320.1 - 2.7e-19 69.5 23.7 8.2e-07 29.6 1.0 6.4 2 1 5 7 7 6 6 Tetratricopeptide repeat TPR_4 PF07721.14 KOO23320.1 - 1.8e-12 46.6 16.2 0.18 12.5 0.0 7.5 7 0 0 7 7 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23320.1 - 5.4e-11 42.3 31.2 0.041 14.7 0.4 7.8 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOO23320.1 - 1.3e-10 40.9 9.0 0.28 11.7 0.0 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23320.1 - 1.7e-08 34.9 19.8 0.012 16.1 0.5 4.9 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_21 PF09976.9 KOO23320.1 - 4.1e-05 23.4 9.6 0.52 10.0 2.3 4.4 1 1 3 4 4 4 3 Tetratricopeptide repeat-like domain TPR_5 PF12688.7 KOO23320.1 - 0.00015 22.0 11.7 0.43 10.8 0.7 4.5 1 1 2 3 3 3 2 Tetratrico peptide repeat Osmo_CC PF08946.10 KOO23320.1 - 0.00027 21.1 0.5 4.4 7.6 0.1 4.5 4 0 0 4 4 4 1 Osmosensory transporter coiled coil HisKA_3 PF07730.13 KOO23320.1 - 0.0034 17.9 16.2 2.2 8.8 0.1 5.5 3 2 1 5 5 5 1 Histidine kinase TPR_3 PF07720.12 KOO23320.1 - 0.012 15.6 0.0 8.9 6.4 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TetR_C_18 PF17923.1 KOO23320.1 - 0.03 14.8 4.1 20 5.7 0.0 4.5 2 1 2 4 4 4 0 Tetracyclin repressor-like, C-terminal domain DUF4404 PF14357.6 KOO23320.1 - 0.05 14.3 1.3 1.9 9.2 0.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) RPN6_N PF18055.1 KOO23320.1 - 0.091 13.1 0.9 20 5.6 0.1 3.1 2 1 1 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain MIT PF04212.18 KOO23320.1 - 0.092 12.8 0.3 46 4.2 0.0 3.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 KOO23320.1 - 0.13 12.0 12.1 12 5.7 0.2 5.3 5 0 0 5 5 5 0 TPR repeat Glucosamine_iso PF01182.20 KOO23322.1 - 7.4e-28 98.0 0.0 9.9e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Complex1_51K PF01512.17 KOO23322.1 - 0.14 12.0 0.0 0.35 10.7 0.0 1.6 2 0 0 2 2 2 0 Respiratory-chain NADH dehydrogenase 51 Kd subunit TPR_10 PF13374.6 KOO23324.1 - 2.3e-74 243.5 27.5 1.7e-12 46.8 0.0 8.7 7 1 1 8 8 8 8 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23324.1 - 4e-69 228.9 29.0 3.5e-16 59.2 1.1 5.8 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23324.1 - 3.6e-25 86.7 6.0 0.0055 16.5 0.0 8.5 7 1 1 8 8 8 6 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO23324.1 - 1.5e-22 80.5 9.2 1e-08 34.9 2.2 3.5 1 1 2 3 3 3 3 MalT-like TPR region TPR_7 PF13176.6 KOO23324.1 - 4.8e-20 70.1 14.3 0.0073 16.3 0.0 8.5 7 1 1 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23324.1 - 2.7e-19 67.7 8.1 0.007 16.5 0.0 8.6 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23324.1 - 4.3e-18 63.9 13.3 0.18 12.0 0.0 8.9 7 1 1 8 8 8 7 Tetratricopeptide repeat TPR_4 PF07721.14 KOO23324.1 - 3.1e-12 45.9 27.5 0.028 15.0 0.2 10.1 9 1 1 10 10 8 4 Tetratricopeptide repeat TPR_3 PF07720.12 KOO23324.1 - 1.4e-09 37.7 0.0 1.5 8.9 0.0 6.7 8 0 0 8 8 7 2 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO23324.1 - 4.2e-09 36.5 6.8 5.3 7.4 0.0 6.9 7 0 0 7 7 7 2 Osmosensory transporter coiled coil TPR_17 PF13431.6 KOO23324.1 - 5e-09 35.9 8.5 8.4 7.0 0.0 7.9 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23324.1 - 2.2e-06 28.2 38.0 0.021 15.5 0.2 8.7 3 1 6 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23324.1 - 2.6e-05 24.6 21.0 0.15 12.6 1.1 5.4 2 1 2 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23324.1 - 5.2e-05 23.7 36.0 0.44 11.5 0.3 9.3 8 2 2 10 10 8 4 Tetratricopeptide repeat TPR_5 PF12688.7 KOO23324.1 - 0.0012 19.1 13.5 0.46 10.7 1.3 5.0 1 1 2 4 4 4 2 Tetratrico peptide repeat RPN6_N PF18055.1 KOO23324.1 - 0.053 13.9 0.3 13 6.2 0.0 3.4 2 2 2 4 4 4 0 26S proteasome regulatory subunit RPN6 N-terminal domain BRCC36_C PF18110.1 KOO23324.1 - 0.12 12.6 0.0 8 6.7 0.0 3.4 4 0 0 4 4 4 0 BRCC36 C-terminal helical domain TPR_11 PF13414.6 KOO23324.1 - 0.35 10.6 7.1 66 3.3 0.0 6.0 7 0 0 7 7 7 0 TPR repeat Ion_trans PF00520.31 KOO23325.1 - 1.5e-07 30.9 4.6 3.4e-07 29.7 4.6 1.7 1 0 0 1 1 1 1 Ion transport protein Ank_3 PF13606.6 KOO23325.1 - 0.033 14.7 0.0 24 5.9 0.0 3.8 3 0 0 3 3 3 0 Ankyrin repeat Sulfotransfer_3 PF13469.6 KOO23327.1 - 4.5e-09 37.0 0.1 0.25 11.7 0.0 3.5 2 1 1 3 3 3 3 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO23327.1 - 3.4e-05 23.5 0.0 0.057 12.9 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KOO23328.1 - 5.9e-09 36.6 0.1 0.27 11.6 0.0 3.5 2 1 1 3 3 3 3 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO23328.1 - 3.8e-05 23.3 0.0 0.056 12.9 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase domain zf-RanBP PF00641.18 KOO23329.1 - 1.5e-05 24.2 2.3 2.6e-05 23.4 2.3 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DZR PF12773.7 KOO23329.1 - 0.00027 20.9 0.6 0.00048 20.1 0.6 1.4 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 KOO23329.1 - 0.024 14.3 2.5 0.048 13.4 2.5 1.5 1 0 0 1 1 1 0 zinc-ribbon domain TruD PF01142.18 KOO23332.1 - 4.6e-67 226.6 0.0 2.1e-64 217.9 0.0 2.1 1 1 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) DEAD PF00270.29 KOO23333.1 - 7.8e-40 136.5 0.0 4.2e-39 134.1 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO23333.1 - 6.2e-25 87.7 0.0 1.2e-24 86.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 KOO23333.1 - 7.4e-09 35.7 7.8 2.3e-08 34.2 7.8 1.8 1 1 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.15 KOO23333.1 - 8.5e-05 22.6 0.0 0.00016 21.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Aha1_N PF09229.11 KOO23334.1 - 9.5e-15 55.0 0.9 4e-14 53.0 0.0 2.6 3 0 0 3 3 3 1 Activator of Hsp90 ATPase, N-terminal TPR_2 PF07719.17 KOO23334.1 - 2.8e-07 30.1 7.3 0.049 13.8 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23334.1 - 1.2e-06 28.1 5.9 0.21 11.5 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23334.1 - 7.1e-05 22.4 4.9 0.0044 16.7 0.5 3.4 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 KOO23334.1 - 8.1e-05 22.5 5.9 0.033 14.4 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO23334.1 - 0.00013 22.0 12.0 0.00071 19.7 2.6 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO23334.1 - 0.29 11.8 6.9 18 6.2 0.2 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO23334.1 - 0.46 11.0 3.5 1.1 9.8 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Galactosyl_T PF01762.21 KOO23335.1 - 1.8e-05 24.6 0.0 4.5e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 KOO23335.1 - 0.097 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Fringe-like Methyltransf_21 PF05050.12 KOO23336.1 - 6.9e-09 36.0 0.0 1.9e-08 34.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase FkbM domain Peroxin-3 PF04882.12 KOO23337.1 - 1.7e-17 63.6 9.5 1.4e-07 30.9 0.0 4.1 1 1 2 3 3 3 3 Peroxin-3 Trehalase PF01204.18 KOO23338.1 - 3.2e-06 26.3 0.0 0.00038 19.4 0.0 2.8 2 1 0 2 2 2 2 Trehalase Glyco_hydro_63 PF03200.16 KOO23338.1 - 0.028 13.2 0.0 0.045 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 C-terminal domain MOR2-PAG1_N PF14222.6 KOO23339.1 - 1.3e-09 37.5 1.2 1.5e-08 34.1 0.8 2.1 2 0 0 2 2 2 2 Cell morphogenesis N-terminal DHHC PF01529.20 KOO23340.1 - 1.3e-36 125.7 13.4 1.3e-36 125.7 13.4 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF1129 PF06570.11 KOO23340.1 - 0.31 10.5 1.2 3.3 7.1 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Yip1 PF04893.17 KOO23340.1 - 1.5 8.5 8.4 0.19 11.4 0.2 2.7 3 0 0 3 3 3 0 Yip1 domain SKG6 PF08693.10 KOO23340.1 - 3.5 7.1 7.9 1.3 8.4 4.4 2.1 3 0 0 3 3 3 0 Transmembrane alpha-helix domain LapA_dom PF06305.11 KOO23340.1 - 4.7 7.1 6.1 21 5.0 0.0 2.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain RRM_1 PF00076.22 KOO23341.1 - 2.2e-22 78.7 0.0 9.7e-12 44.5 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OST-HTH PF12872.7 KOO23341.1 - 0.0084 15.9 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 OST-HTH/LOTUS domain IPU_b_solenoid PF18783.1 KOO23341.1 - 0.24 11.5 0.3 0.46 10.6 0.3 1.4 1 0 0 1 1 1 0 Isopullulanase beta-solenoid repeat Kinesin PF00225.23 KOO23342.1 - 1.5e-78 264.1 0.0 2.7e-78 263.2 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO23342.1 - 6.1e-16 58.7 0.0 1.7e-14 54.0 0.0 2.5 2 0 0 2 2 2 1 Microtubule binding 2OG-FeII_Oxy_3 PF13640.6 KOO23343.1 - 0.0032 18.3 0.0 0.0051 17.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Tudor-knot PF11717.8 KOO23344.1 - 0.0024 17.7 0.0 0.0054 16.6 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Borrelia_P83 PF05262.11 KOO23344.1 - 5.7 5.3 8.0 7.8 4.9 8.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Filamin PF00630.19 KOO23345.1 - 6.4e-46 155.4 0.0 1e-16 61.6 0.0 7.2 6 2 0 6 6 6 5 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO23345.1 - 2e-07 31.3 0.0 0.26 11.6 0.0 4.4 4 0 0 4 4 4 2 Invasin, domain 3 Neurexophilin PF06312.12 KOO23345.1 - 0.00078 19.0 0.3 0.0093 15.5 0.1 2.2 2 0 0 2 2 2 1 Neurexophilin Cadherin_5 PF17892.1 KOO23345.1 - 0.12 12.3 0.9 5.1 7.1 0.0 3.4 4 0 0 4 4 4 0 Cadherin-like domain LRRNT PF01462.18 KOO23345.1 - 3.3 7.5 5.7 4.9 6.9 3.4 2.5 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Metallophos_2 PF12850.7 KOO23346.1 - 3.6e-08 33.8 0.0 5.9e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MOSC PF03473.17 KOO23346.1 - 0.0013 18.7 0.0 0.0025 17.8 0.0 1.5 1 0 0 1 1 1 1 MOSC domain AAA PF00004.29 KOO23349.1 - 6.7e-16 58.9 0.2 2.4e-07 31.2 0.0 3.7 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO23349.1 - 5.2e-06 26.5 0.0 1.5e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO23349.1 - 3.4e-05 24.3 0.1 0.0008 19.8 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 KOO23349.1 - 0.0011 18.8 0.0 0.0048 16.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOO23349.1 - 0.0053 17.1 0.0 0.049 14.0 0.0 2.6 3 0 0 3 3 3 1 RNA helicase AAA_30 PF13604.6 KOO23349.1 - 0.0064 16.2 0.7 0.049 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 KOO23349.1 - 0.0091 16.3 0.2 0.034 14.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO23349.1 - 0.0092 16.3 0.1 0.11 12.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOO23349.1 - 0.0099 16.2 1.1 0.24 11.7 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO23349.1 - 0.016 15.3 0.0 0.055 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 KOO23349.1 - 0.025 13.6 0.0 0.048 12.6 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_18 PF13238.6 KOO23349.1 - 0.029 14.9 0.0 0.09 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 KOO23349.1 - 0.036 13.8 0.0 0.072 12.8 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 KOO23349.1 - 0.04 13.1 0.0 0.089 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Rad17 PF03215.15 KOO23349.1 - 0.053 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_7 PF12775.7 KOO23349.1 - 0.068 12.7 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 KOO23349.1 - 0.069 13.1 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IPT PF01745.16 KOO23349.1 - 0.14 11.5 0.0 0.43 9.9 0.0 1.8 1 0 0 1 1 1 0 Isopentenyl transferase IBR PF01485.21 KOO23350.1 - 0.0012 19.1 9.7 0.0023 18.1 9.7 1.5 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain Slu7 PF11708.8 KOO23351.1 - 1.9e-73 247.6 14.0 1.9e-73 247.6 14.0 1.5 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 KOO23351.1 - 0.084 12.6 1.9 0.13 12.0 0.5 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 KOO23351.1 - 1.2 8.9 6.8 1.1 9.0 1.9 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.23 KOO23351.1 - 1.6 9.0 3.8 0.9 9.7 1.6 1.8 2 0 0 2 2 2 0 Zinc knuckle Fer2 PF00111.27 KOO23352.1 - 6.1e-07 29.3 1.5 8.5e-07 28.8 1.5 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain MCR PF18509.1 KOO23352.1 - 0.044 13.4 0.9 0.15 11.6 0.2 2.3 2 0 0 2 2 2 0 Magnetochrome domain Pkinase PF00069.25 KOO23354.1 - 3.3e-47 161.1 0.0 4e-47 160.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23354.1 - 2.6e-34 118.7 0.0 3.3e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO23354.1 - 6.9e-06 25.1 0.0 9.9e-06 24.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO23354.1 - 0.00016 21.1 0.0 0.00027 20.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KOO23354.1 - 0.013 14.5 0.0 0.016 14.2 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 KOO23354.1 - 0.052 12.6 0.0 0.076 12.1 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Herpes_capsid PF06112.11 KOO23354.1 - 1.6 8.8 10.4 2.7 8.0 10.4 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein DEAD PF00270.29 KOO23355.1 - 3.1e-45 154.1 0.0 5.7e-45 153.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO23355.1 - 1.6e-06 28.2 0.0 2.4e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOO23355.1 - 0.051 13.9 0.6 0.85 9.9 0.6 2.7 1 1 0 1 1 1 0 AAA domain CMS1 PF14617.6 KOO23355.1 - 0.11 11.8 0.0 1.1 8.6 0.0 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit ABC_membrane PF00664.23 KOO23356.1 - 1.5e-64 218.3 29.2 6.8e-33 114.5 10.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOO23356.1 - 1.2e-33 116.5 0.0 2.6e-33 115.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOO23356.1 - 9.8e-07 28.4 1.9 3.9e-05 23.2 1.9 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KOO23356.1 - 0.0016 18.7 0.2 0.016 15.5 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 KOO23356.1 - 0.0028 17.3 0.1 0.0073 16.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 KOO23356.1 - 0.0057 16.0 0.2 0.033 13.5 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.6 KOO23356.1 - 0.0093 16.4 2.0 0.011 16.1 0.4 2.0 2 1 0 2 2 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 KOO23356.1 - 0.018 15.0 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 KOO23356.1 - 0.019 14.7 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 KOO23356.1 - 0.026 14.7 0.2 0.48 10.7 0.2 2.9 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit APS_kinase PF01583.20 KOO23356.1 - 0.031 14.2 0.1 0.074 13.0 0.1 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.6 KOO23356.1 - 0.038 14.5 0.0 0.1 13.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain G-alpha PF00503.20 KOO23356.1 - 0.045 12.9 0.0 0.075 12.2 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_21 PF13304.6 KOO23356.1 - 0.052 13.3 0.0 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 KOO23356.1 - 0.078 13.4 1.3 0.91 10.0 1.3 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 KOO23356.1 - 0.079 12.5 0.1 1.5 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain HALZ PF02183.18 KOO23357.1 - 0.016 15.4 0.4 0.063 13.5 0.4 2.1 1 0 0 1 1 1 0 Homeobox associated leucine zipper PDZ_6 PF17820.1 KOO23357.1 - 0.029 14.2 0.0 0.086 12.7 0.0 1.8 1 0 0 1 1 1 0 PDZ domain Mononeg_mRNAcap PF14318.6 KOO23357.1 - 0.055 12.7 2.4 0.95 8.7 1.3 2.2 1 1 1 2 2 2 0 Mononegavirales mRNA-capping region V DUF378 PF04070.12 KOO23357.1 - 0.082 12.8 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF378) PDZ_2 PF13180.6 KOO23357.1 - 0.16 12.3 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 PDZ domain Methyltransf_23 PF13489.6 KOO23358.1 - 4.6e-07 29.8 0.0 5.1e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO23358.1 - 9e-07 29.5 0.0 1.2e-06 29.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23358.1 - 1.1e-06 29.2 0.0 1.5e-06 28.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO23358.1 - 1.1e-05 26.0 0.0 1.5e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO23358.1 - 0.002 17.9 0.0 0.0022 17.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 KOO23358.1 - 0.031 12.8 0.0 0.04 12.5 0.0 1.0 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 KOO23358.1 - 0.062 12.6 0.0 0.071 12.4 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family TIR_2 PF13676.6 KOO23359.1 - 3.2e-18 66.4 0.0 1.2e-08 35.6 0.0 3.4 3 0 0 3 3 3 2 TIR domain Proteasom_PSMB PF10508.9 KOO23359.1 - 1.7e-05 23.6 5.0 0.065 11.7 0.0 3.7 4 0 0 4 4 4 2 Proteasome non-ATPase 26S subunit Anti-adapt_IraP PF10796.9 KOO23359.1 - 0.01 16.4 7.4 7.3 7.2 0.0 4.7 4 0 0 4 4 4 0 Sigma-S stabilisation anti-adaptor protein DUF3636 PF12331.8 KOO23359.1 - 0.029 14.2 0.4 0.54 10.1 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) TIR PF01582.20 KOO23359.1 - 0.03 14.1 0.0 9.5 6.0 0.0 2.8 3 0 0 3 3 3 0 TIR domain DUF2016 PF09436.10 KOO23359.1 - 0.082 12.7 0.1 28 4.6 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2016) DUF2922 PF11148.8 KOO23359.1 - 0.12 12.1 0.0 0.55 10.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2922) Arm PF00514.23 KOO23359.1 - 0.16 12.0 30.0 0.71 10.0 0.0 11.6 14 0 0 14 14 14 0 Armadillo/beta-catenin-like repeat DUF969 PF06149.12 KOO23359.1 - 0.19 11.1 4.7 6.4 6.1 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF969) Pro_isomerase PF00160.21 KOO23360.1 - 4.1e-43 147.4 0.0 6.4e-43 146.8 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CS PF04969.16 KOO23360.1 - 0.00051 21.0 0.0 0.00084 20.3 0.0 1.4 1 0 0 1 1 1 1 CS domain Mannosyl_trans3 PF11051.8 KOO23361.1 - 0.016 14.6 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Mannosyltransferase putative PP_kinase PF02503.17 KOO23362.1 - 0.013 15.1 0.1 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 Polyphosphate kinase middle domain Pox_E2-like PF04497.12 KOO23363.1 - 0.027 13.0 0.0 0.028 12.9 0.0 1.0 1 0 0 1 1 1 0 Poxviridae protein YccV-like PF08755.11 KOO23364.1 - 1.8e-16 60.4 0.0 2.8e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like DUF4099 PF13351.6 KOO23365.1 - 0.014 15.6 0.1 0.044 14.0 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4099) FUSC PF04632.12 KOO23365.1 - 0.28 9.7 19.0 0.35 9.4 19.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family AAA_27 PF13514.6 KOO23365.1 - 1.5 8.3 9.7 0.16 11.5 4.3 2.0 1 1 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 KOO23365.1 - 1.7 8.2 15.2 2.4 7.7 15.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6_N PF17675.1 KOO23365.1 - 2.8 8.5 28.0 9 6.8 13.9 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region Spc7 PF08317.11 KOO23365.1 - 3.7 6.3 25.2 4.7 6.0 21.7 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein dCache_3 PF14827.6 KOO23365.1 - 4.1 7.0 9.5 8.5 5.9 9.5 1.5 1 1 0 1 1 1 0 Double sensory domain of two-component sensor kinase DUF1664 PF07889.12 KOO23365.1 - 4.9 7.2 13.6 2.7 8.0 3.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cauli_AT PF03233.13 KOO23365.1 - 6 6.8 7.0 13 5.7 1.5 2.1 1 1 1 2 2 2 0 Aphid transmission protein V_ATPase_I PF01496.19 KOO23365.1 - 6.6 4.5 10.2 7.4 4.4 10.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PIN_8 PF18476.1 KOO23365.1 - 8.5 6.2 10.3 8.5 6.2 9.1 1.4 1 1 0 1 1 1 0 PIN like domain MscS_porin PF12795.7 KOO23365.1 - 9.7 5.7 37.7 2.8 7.4 31.2 2.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Aldo_ket_red PF00248.21 KOO23366.1 - 1.7e-22 80.0 0.0 1.2e-17 64.1 0.0 2.1 1 1 1 2 2 2 2 Aldo/keto reductase family PAP_fibrillin PF04755.12 KOO23367.1 - 7.9e-05 22.7 0.0 0.11 12.4 0.0 2.8 2 1 0 2 2 2 2 PAP_fibrillin XPA_C PF05181.12 KOO23369.1 - 5.9e-11 42.2 0.0 1.1e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 XPA protein C-terminus EF-hand_6 PF13405.6 KOO23369.1 - 2.6e-06 26.9 0.0 4.2e-05 23.1 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO23369.1 - 4.5e-06 25.8 0.0 8.8e-05 21.8 0.2 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO23369.1 - 7e-05 23.2 0.1 0.00027 21.3 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO23369.1 - 0.0016 17.9 0.1 0.0031 16.9 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO23369.1 - 0.052 13.4 0.1 0.14 12.0 0.1 1.7 1 1 1 2 2 2 0 EF-hand domain pair zf-dskA_traR PF01258.17 KOO23369.1 - 0.12 12.4 3.0 0.45 10.5 3.0 2.1 1 1 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger APG6_N PF17675.1 KOO23369.1 - 0.38 11.3 5.2 0.9 10.1 5.2 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Selenoprotein_S PF06936.11 KOO23371.1 - 0.017 14.9 3.6 0.017 14.9 3.6 3.0 2 1 1 3 3 3 0 Selenoprotein S (SelS) SOBP PF15279.6 KOO23371.1 - 7.9 7.0 8.7 61 4.1 0.1 2.1 1 1 0 2 2 2 0 Sine oculis-binding protein Ank_2 PF12796.7 KOO23372.1 - 1.3e-22 80.1 5.5 1.8e-12 47.7 1.7 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO23372.1 - 5.5e-18 64.5 6.5 1.4e-06 28.5 1.4 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO23372.1 - 1.5e-15 57.0 7.1 1.3e-08 34.9 0.8 4.2 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO23372.1 - 1.6e-15 57.3 5.1 3.9e-10 40.1 0.5 4.0 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO23372.1 - 5.1e-14 51.0 6.3 8.8e-06 25.7 0.2 4.5 4 1 0 4 4 4 3 Ankyrin repeat U-box PF04564.15 KOO23372.1 - 9.8e-13 48.1 0.0 1.7e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO23372.1 - 1.4e-05 24.8 0.0 2.5e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SHIPPO-rpt PF07004.12 KOO23373.1 - 2.5e-15 56.5 38.3 0.011 16.7 2.4 10.3 10 0 0 10 10 10 5 Sperm-tail PG-rich repeat CHAD PF05235.14 KOO23373.1 - 0.036 14.0 0.0 0.065 13.2 0.0 1.3 1 0 0 1 1 1 0 CHAD domain DUF4295 PF14128.6 KOO23373.1 - 0.081 12.8 0.1 0.33 10.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4295) AAA_7 PF12775.7 KOO23374.1 - 2.2e-09 37.1 0.2 0.0027 17.2 0.0 3.5 3 0 0 3 3 3 3 P-loop containing dynein motor region AAA PF00004.29 KOO23374.1 - 1.3e-08 35.4 0.1 1.2e-05 25.8 0.0 4.7 5 0 0 5 5 5 1 ATPase family associated with various cellular activities (AAA) VWA PF00092.28 KOO23374.1 - 1.6e-07 31.8 0.0 1.1e-06 29.0 0.0 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 KOO23374.1 - 2.9e-07 31.1 0.0 2.4e-06 28.1 0.0 2.8 2 0 0 2 2 2 1 von Willebrand factor type A domain AAA_22 PF13401.6 KOO23374.1 - 0.00014 22.2 0.4 0.54 10.5 0.0 4.1 4 0 0 4 4 4 2 AAA domain NACHT PF05729.12 KOO23374.1 - 0.003 17.5 0.1 0.17 11.8 0.0 3.6 2 0 0 2 2 2 1 NACHT domain AAA_19 PF13245.6 KOO23374.1 - 0.0036 17.6 0.0 0.65 10.3 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 KOO23374.1 - 0.13 12.1 0.0 12 5.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 KOO23374.1 - 0.14 12.0 0.0 0.53 10.2 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea GBP PF02263.19 KOO23376.1 - 9.6e-64 215.1 0.0 1.2e-63 214.8 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 KOO23376.1 - 6.9e-12 45.4 0.0 9.8e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain RHD3 PF05879.12 KOO23376.1 - 0.051 11.7 0.0 0.078 11.1 0.0 1.2 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) Pkinase PF00069.25 KOO23377.1 - 8.2e-05 22.1 0.0 0.00013 21.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF1811 PF08838.10 KOO23378.1 - 0.47 10.7 6.3 0.98 9.7 0.6 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1811) TMCO5 PF14992.6 KOO23378.1 - 5.2 6.6 10.3 0.077 12.6 3.1 1.5 2 0 0 2 2 2 0 TMCO5 family GAS PF13851.6 KOO23378.1 - 9.1 5.6 13.8 0.18 11.1 5.7 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding ThiF PF00899.21 KOO23379.1 - 3.3e-94 314.8 0.0 9.8e-69 231.4 0.0 3.0 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 KOO23379.1 - 9.3e-64 215.8 0.0 1.2e-63 215.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 KOO23379.1 - 1.3e-15 57.4 0.0 2.1e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 KOO23379.1 - 8.9e-15 55.2 0.0 1.9e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain Shikimate_DH PF01488.20 KOO23379.1 - 0.027 14.5 0.2 0.82 9.7 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 KOO23379.1 - 0.077 12.4 0.0 9.9 5.5 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Filamin PF00630.19 KOO23380.1 - 4.1e-50 168.9 0.0 3.8e-18 66.2 0.0 7.5 7 1 0 7 7 7 7 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO23380.1 - 7.4e-19 67.9 0.8 1.8e-05 25.0 0.0 5.4 6 0 0 6 6 6 3 Invasin, domain 3 Big_1 PF02369.16 KOO23380.1 - 2.9e-06 27.2 2.1 0.039 13.9 0.3 3.9 4 0 0 4 4 4 2 Bacterial Ig-like domain (group 1) CHRD PF07452.12 KOO23380.1 - 0.0034 18.3 0.3 0.39 11.7 0.0 3.4 3 1 0 3 3 3 1 CHRD domain Cadherin_5 PF17892.1 KOO23380.1 - 0.036 14.0 0.8 2.4 8.2 0.0 3.1 3 0 0 3 3 3 0 Cadherin-like domain GBV-C_env PF12786.7 KOO23380.1 - 0.042 12.5 0.3 0.072 11.8 0.3 1.2 1 0 0 1 1 1 0 GB virus C genotype envelope BclA_C PF18573.1 KOO23380.1 - 0.063 13.2 0.0 0.58 10.1 0.0 2.6 3 0 0 3 3 3 0 BclA C-terminal domain Big_3_5 PF16640.5 KOO23380.1 - 1.1 9.4 4.4 7.3 6.8 0.1 3.2 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) Thioredoxin PF00085.20 KOO23381.1 - 3.2e-08 33.5 0.0 9e-08 32.0 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 KOO23381.1 - 0.019 14.9 0.0 0.14 12.1 0.0 2.2 2 1 1 3 3 3 0 Thioredoxin-like domain DUF2968 PF11180.8 KOO23381.1 - 0.13 11.9 3.1 0.16 11.6 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) YebO PF13974.6 KOO23381.1 - 0.46 10.6 2.1 0.88 9.7 2.1 1.4 1 0 0 1 1 1 0 YebO-like protein DHHC PF01529.20 KOO23382.1 - 9.5e-31 106.7 13.5 9.5e-31 106.7 13.5 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2208 PF09973.9 KOO23382.1 - 0.45 10.1 9.1 3.8 7.1 4.4 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2208) Coatomer_g_Cpla PF16381.5 KOO23383.1 - 0.017 15.3 0.9 0.026 14.7 0.9 1.3 1 0 0 1 1 1 0 Coatomer subunit gamma-1 C-terminal appendage platform MFS_3 PF05977.13 KOO23383.1 - 0.062 11.7 1.3 0.067 11.6 1.3 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector SseB PF07179.12 KOO23383.1 - 0.17 12.1 6.0 0.21 11.8 6.0 1.1 1 0 0 1 1 1 0 SseB protein N-terminal domain Spore_III_AF PF09581.10 KOO23383.1 - 0.71 9.9 10.5 0.85 9.6 10.5 1.0 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF2960 PF11173.8 KOO23385.1 - 0.0067 16.9 1.4 23 5.5 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2960) AP2 PF00847.20 KOO23385.1 - 0.04 14.2 8.6 0.8 10.0 0.0 3.7 3 0 0 3 3 3 0 AP2 domain DUF1906 PF08924.11 KOO23385.1 - 0.045 13.9 0.4 0.74 9.9 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1906) Anophelin PF10731.9 KOO23385.1 - 0.049 13.5 0.0 13 5.7 0.0 2.3 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito HNF-1A_C PF04813.12 KOO23385.1 - 0.12 13.1 0.0 55 4.6 0.0 3.0 3 0 0 3 3 3 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus PET117 PF15786.5 KOO23385.1 - 0.13 12.5 0.0 31 4.9 0.0 3.1 1 1 1 2 2 2 0 PET assembly of cytochrome c oxidase, mitochondrial VARLMGL PF14383.6 KOO23385.1 - 0.19 11.3 0.5 22 4.7 0.1 2.4 2 0 0 2 2 2 0 DUF761-associated sequence motif Tom5 PF10642.9 KOO23385.1 - 9.7 6.3 7.3 15 5.7 0.2 3.1 2 1 1 3 3 3 0 Mitochondrial import receptor subunit or translocase Glyco_hydro_3_C PF01915.22 KOO23386.1 - 2.4e-47 161.5 0.0 4.6e-47 160.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOO23386.1 - 7e-21 74.9 0.0 1.6e-20 73.7 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOO23386.1 - 1.4e-14 54.0 0.0 2.8e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Filamin PF00630.19 KOO23387.1 - 1.1e-64 215.7 0.0 5.9e-16 59.2 0.0 7.4 7 0 0 7 7 7 6 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO23387.1 - 5.8e-07 29.7 8.7 0.57 10.5 0.1 6.3 5 1 0 5 5 5 3 Invasin, domain 3 YtkA PF13115.6 KOO23387.1 - 1.4e-05 25.6 2.7 0.18 12.4 0.1 4.3 4 1 1 5 5 5 2 YtkA-like Neurexophilin PF06312.12 KOO23387.1 - 0.23 10.9 0.0 0.76 9.2 0.0 1.8 1 0 0 1 1 1 0 Neurexophilin peroxidase PF00141.23 KOO23388.1 - 9.2e-25 87.7 0.1 1.6e-24 86.9 0.1 1.4 1 1 0 1 1 1 1 Peroxidase PAP_fibrillin PF04755.12 KOO23389.1 - 3.3e-05 23.9 0.0 0.034 14.1 0.0 2.2 2 0 0 2 2 2 2 PAP_fibrillin DUF4452 PF14618.6 KOO23389.1 - 0.053 13.4 0.1 0.088 12.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4452) MFS_1 PF07690.16 KOO23391.1 - 4.7e-31 108.0 19.6 6e-31 107.6 19.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Abhydrolase_6 PF12697.7 KOO23393.1 - 7.6e-07 29.9 4.8 1.6e-06 28.9 4.8 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO23393.1 - 1.7e-06 27.9 0.1 2.8e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO23393.1 - 8.5e-05 21.9 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF818 PF05677.12 KOO23393.1 - 0.00022 20.3 0.0 0.00041 19.4 0.0 1.4 1 1 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_2 PF02230.16 KOO23393.1 - 0.03 14.1 0.0 0.046 13.5 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KOO23393.1 - 0.059 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family DnaJ_C PF01556.18 KOO23394.1 - 0.026 14.6 0.0 2.1 8.4 0.0 2.8 1 1 0 1 1 1 0 DnaJ C terminal domain NPCBM_assoc PF10633.9 KOO23394.1 - 0.062 13.6 0.4 15 5.9 0.0 3.0 1 1 2 3 3 3 0 NPCBM-associated, NEW3 domain of alpha-galactosidase NUMOD1 PF07453.13 KOO23395.1 - 0.18 12.1 0.0 24 5.3 0.0 3.3 3 0 0 3 3 3 0 NUMOD1 domain DUF4407 PF14362.6 KOO23396.1 - 0.37 10.1 12.2 0.59 9.4 12.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CREPT PF16566.5 KOO23396.1 - 2.3 8.4 6.9 5.4 7.2 6.9 1.7 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour AT_hook PF02178.19 KOO23396.1 - 3.2 8.0 9.7 9 6.6 1.5 3.9 3 0 0 3 3 3 0 AT hook motif DUF1917 PF08939.10 KOO23397.1 - 7.7e-20 71.9 0.0 7.7e-20 71.9 0.0 4.3 3 2 2 5 5 5 2 Domain of unknown function (DUF1917) DUF179 PF02622.15 KOO23398.1 - 8.9e-05 22.5 0.0 0.00038 20.4 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 Transglut_core2 PF13369.6 KOO23398.1 - 0.00014 21.5 0.1 0.00025 20.6 0.1 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily FAD_binding_3 PF01494.19 KOO23400.1 - 8.3e-08 31.9 0.1 0.00039 19.8 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain SE PF08491.10 KOO23400.1 - 0.25 10.3 0.0 0.38 9.8 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase MMR_HSR1_Xtn PF16897.5 KOO23401.1 - 1.2e-37 128.2 0.4 2.4e-37 127.2 0.4 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 KOO23401.1 - 1.9e-20 73.0 0.0 7.1e-20 71.2 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 KOO23401.1 - 7e-16 58.0 0.2 1.4e-15 57.1 0.2 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 KOO23401.1 - 5.3e-10 39.0 0.0 1e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOO23401.1 - 7.1e-05 22.9 0.0 0.0021 18.1 0.0 2.5 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 KOO23401.1 - 0.017 14.7 0.0 0.38 10.3 0.0 2.6 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain MeaB PF03308.16 KOO23401.1 - 0.06 12.3 0.1 0.5 9.3 0.0 2.3 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ThiS PF02597.20 KOO23402.1 - 9.2 7.0 7.3 6.3 7.5 0.1 3.5 3 1 0 3 3 3 0 ThiS family ThiF PF00899.21 KOO23403.1 - 2.8e-27 95.7 0.0 4.3e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 KOO23403.1 - 0.28 11.2 0.6 0.75 9.9 0.2 1.9 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase CS PF04969.16 KOO23404.1 - 2.3e-10 41.3 0.0 3.9e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 CS domain SnoaL_2 PF12680.7 KOO23405.1 - 0.068 13.8 0.1 0.13 12.9 0.1 1.7 1 1 0 1 1 1 0 SnoaL-like domain RRM_1 PF00076.22 KOO23406.1 - 5.9e-38 128.5 0.0 1.3e-19 69.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOO23406.1 - 0.00051 20.1 0.0 0.0039 17.3 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 KOO23406.1 - 0.0038 16.8 0.0 0.18 11.4 0.0 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 KOO23406.1 - 0.011 15.4 1.5 0.4 10.4 0.3 2.5 2 1 0 2 2 2 0 Ribonuclease B OB domain Epimerase PF01370.21 KOO23408.1 - 9.1e-15 54.8 0.0 1.2e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KOO23408.1 - 4.9e-08 33.1 0.1 1.4e-07 31.6 0.1 1.8 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 KOO23408.1 - 3e-06 26.6 0.0 4.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain DUF957 PF06117.11 KOO23408.1 - 0.2 11.2 0.0 0.67 9.6 0.0 1.8 2 0 0 2 2 2 0 Enterobacterial protein of unknown function (DUF957) Sec23_trunk PF04811.15 KOO23410.1 - 6.8e-06 25.8 0.0 4.7e-05 23.1 0.0 2.2 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain NAD_Gly3P_dh_C PF07479.14 KOO23412.1 - 3e-48 163.7 0.2 5e-48 163.0 0.2 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 KOO23412.1 - 4.7e-35 120.9 0.0 1.4e-34 119.4 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus SARG PF15385.6 KOO23413.1 - 0.031 13.5 0.4 0.031 13.5 0.4 2.0 2 0 0 2 2 2 0 Specifically androgen-regulated gene protein FAM176 PF14851.6 KOO23413.1 - 0.034 13.8 4.1 0.028 14.1 2.4 1.6 1 1 1 2 2 2 0 FAM176 family Nucleo_P87 PF07267.11 KOO23413.1 - 0.063 12.1 1.0 0.088 11.6 1.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Scramblase PF03803.15 KOO23415.1 - 1.1e-13 51.0 0.0 1.7e-07 30.8 0.0 2.3 2 0 0 2 2 2 2 Scramblase Peptidase_C74 PF12387.8 KOO23415.1 - 0.16 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Pestivirus NS2 peptidase Pkinase PF00069.25 KOO23417.1 - 3.6e-52 177.3 0.0 7.4e-52 176.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23417.1 - 1.1e-22 80.6 0.0 1.5e-18 67.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 KOO23417.1 - 0.0048 16.3 0.0 0.0097 15.3 0.0 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO23417.1 - 0.032 13.5 0.0 0.18 11.1 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 KOO23417.1 - 0.22 10.4 0.0 0.33 9.9 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain EF-hand_6 PF13405.6 KOO23419.1 - 1.3e-10 40.3 0.1 0.00048 19.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO23419.1 - 1.1e-09 37.2 0.1 0.00041 19.7 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO23419.1 - 7.5e-09 35.9 0.0 1.5e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO23419.1 - 2.4e-06 26.8 0.5 0.094 12.3 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO23419.1 - 5.5e-05 22.9 0.7 0.0076 16.1 0.0 2.6 2 1 1 3 3 3 2 EF-hand domain pair Sigma54_activat PF00158.26 KOO23419.1 - 0.075 12.7 0.8 0.14 11.8 0.8 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain 14-3-3 PF00244.20 KOO23420.1 - 1.1e-94 316.1 4.3 1.3e-94 315.9 4.3 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_8 PF13181.6 KOO23420.1 - 0.96 9.8 5.8 1.6 9.1 0.5 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Nuc_sug_transp PF04142.15 KOO23421.1 - 5.7e-85 285.2 18.9 7e-85 285.0 18.9 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO23421.1 - 3.8e-05 23.9 6.0 3.8e-05 23.9 6.0 2.3 2 0 0 2 2 2 2 EamA-like transporter family RTX PF02382.15 KOO23421.1 - 6.4 6.4 10.7 3 7.4 7.5 1.9 2 0 0 2 2 2 0 N-terminal domain in RTX protein DIM1 PF02966.16 KOO23422.1 - 5.9e-67 223.5 0.0 6.6e-67 223.3 0.0 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 KOO23422.1 - 0.0054 16.7 0.0 0.0072 16.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredox_DsbH PF03190.15 KOO23422.1 - 0.15 12.0 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF255 PhyH PF05721.13 KOO23423.1 - 2.5e-13 50.8 0.0 4.3e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) PUNUT PF16913.5 KOO23424.1 - 3.3e-08 33.1 2.9 9.4e-08 31.6 2.9 1.7 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport EamA PF00892.20 KOO23424.1 - 4e-06 27.0 2.4 4e-06 27.0 2.4 3.5 2 1 0 2 2 2 1 EamA-like transporter family UAA PF08449.11 KOO23424.1 - 2e-05 24.0 4.7 5.1e-05 22.6 1.3 2.6 2 1 0 2 2 2 1 UAA transporter family SLC35F PF06027.12 KOO23424.1 - 0.0063 16.1 0.9 0.0063 16.1 0.9 2.4 2 1 0 2 2 2 1 Solute carrier family 35 Nuc_sug_transp PF04142.15 KOO23424.1 - 0.03 13.5 0.2 0.057 12.6 0.2 1.4 1 0 0 1 1 1 0 Nucleotide-sugar transporter TMEM234 PF10639.9 KOO23424.1 - 0.033 14.2 0.3 0.26 11.4 0.1 2.3 2 0 0 2 2 2 0 Putative transmembrane family 234 CRT-like PF08627.10 KOO23424.1 - 0.067 12.1 8.5 0.93 8.4 4.9 2.6 2 1 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like DnaJ PF00226.31 KOO23425.1 - 0.00015 21.8 0.0 0.00042 20.4 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain NHL PF01436.21 KOO23425.1 - 0.0013 18.7 1.2 8.5 6.6 0.0 5.0 5 0 0 5 5 5 1 NHL repeat Gly_reductase PF09338.11 KOO23425.1 - 4.3 5.6 7.1 8.7 4.6 0.4 2.2 2 0 0 2 2 2 0 Glycine/sarcosine/betaine reductase component B subunits GFO_IDH_MocA PF01408.22 KOO23426.1 - 1.3e-27 97.0 0.2 2.6e-27 96.0 0.2 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Shikimate_DH PF01488.20 KOO23426.1 - 0.025 14.6 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 KOO23426.1 - 0.034 14.6 0.0 0.063 13.7 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Trypsin_2 PF13365.6 KOO23427.1 - 7.8e-31 108.0 5.9 8.3e-31 107.9 4.9 1.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.26 KOO23427.1 - 5.6e-14 52.5 0.2 9.2e-14 51.8 0.2 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 KOO23427.1 - 2.6e-12 46.9 0.0 9.2e-12 45.1 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KOO23427.1 - 4.1e-11 42.6 2.5 1.1e-10 41.1 0.2 2.8 3 0 0 3 3 3 1 PDZ domain PDZ PF00595.24 KOO23427.1 - 1.3e-06 28.6 0.0 3.6e-06 27.2 0.0 1.9 1 1 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KOO23427.1 - 0.0011 18.9 0.0 0.0025 17.7 0.0 1.6 1 0 0 1 1 1 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 KOO23427.1 - 0.002 16.8 1.5 0.16 10.6 0.1 2.3 2 0 0 2 2 2 2 Peptidase S46 GRASP55_65 PF04495.14 KOO23427.1 - 0.019 15.2 0.0 0.041 14.2 0.0 1.4 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain Nucleotid_trans PF03407.16 KOO23428.1 - 1.2e-24 87.5 0.0 1.6e-24 87.1 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Pinin_SDK_memA PF04696.13 KOO23430.1 - 1.3e-12 47.9 5.9 1.3e-12 47.9 5.9 2.1 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region TRPM_tetra PF16519.5 KOO23430.1 - 0.36 11.0 3.5 7.5 6.7 0.4 3.2 3 0 0 3 3 3 0 Tetramerisation domain of TRPM DUF963 PF06131.11 KOO23430.1 - 0.99 8.9 14.7 2.1 7.8 14.7 1.5 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) Snf7 PF03357.21 KOO23430.1 - 2.2 7.9 9.8 0.35 10.4 3.6 2.3 2 0 0 2 2 2 0 Snf7 Seryl_tRNA_N PF02403.22 KOO23430.1 - 4.5 7.6 11.8 16 5.7 0.6 3.2 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain RCDG1 PF15725.5 KOO23431.1 - 0.00087 19.7 1.3 0.39 11.2 0.1 2.2 1 1 1 2 2 2 2 Renal cancer differentiation gene 1 protein Coat_F PF07875.12 KOO23432.1 - 0.16 12.2 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Coat F domain Mito_carr PF00153.27 KOO23433.1 - 2.7e-15 56.1 0.6 1.6e-08 34.4 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CcmB PF03379.13 KOO23433.1 - 0.066 12.7 0.1 0.093 12.2 0.1 1.1 1 0 0 1 1 1 0 CcmB protein Atx10homo_assoc PF09759.9 KOO23435.1 - 0.0017 18.3 0.0 3.6 7.7 0.0 4.8 2 2 4 6 6 6 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 KOO23435.1 - 0.0075 16.3 0.5 0.47 10.6 0.0 3.3 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Atg14 PF10186.9 KOO23435.1 - 0.054 12.6 6.8 0.084 11.9 6.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CRR7 PF12095.8 KOO23435.1 - 0.067 13.7 2.8 0.27 11.7 2.8 2.1 1 0 0 1 1 1 0 Protein CHLORORESPIRATORY REDUCTION 7 HBS1_N PF08938.10 KOO23435.1 - 0.13 12.6 3.6 0.34 11.3 3.6 1.7 1 0 0 1 1 1 0 HBS1 N-terminus ADIP PF11559.8 KOO23435.1 - 0.13 12.3 15.9 0.037 14.1 11.1 2.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 KOO23435.1 - 0.2 10.5 14.4 0.33 9.8 14.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Fib_alpha PF08702.10 KOO23435.1 - 0.46 10.7 10.5 0.14 12.4 7.5 1.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Jnk-SapK_ap_N PF09744.9 KOO23435.1 - 0.5 10.6 16.3 1.6 8.9 15.3 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 HMMR_N PF15905.5 KOO23435.1 - 0.79 9.1 17.2 1.2 8.5 17.2 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Exonuc_VII_L PF02601.15 KOO23435.1 - 1.1 8.8 10.4 1.7 8.2 10.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit MCU PF04678.13 KOO23435.1 - 1.3 9.1 6.5 1.5 8.9 5.7 1.5 1 1 0 1 1 1 0 Mitochondrial calcium uniporter TMF_TATA_bd PF12325.8 KOO23435.1 - 1.3 9.2 13.9 1.9 8.8 11.8 2.3 2 1 0 2 2 1 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.11 KOO23435.1 - 1.6 8.9 20.3 3.5 7.8 20.3 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Macoilin PF09726.9 KOO23435.1 - 3.3 6.1 9.5 4.6 5.7 9.5 1.2 1 0 0 1 1 1 0 Macoilin family TPR_MLP1_2 PF07926.12 KOO23435.1 - 5.7 7.0 26.4 25 4.9 1.0 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Cnn_1N PF07989.11 KOO23435.1 - 9 6.5 17.8 0.41 10.9 0.6 3.4 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 SlyX PF04102.12 KOO23435.1 - 9.6 6.9 13.2 10 6.8 2.3 3.5 2 1 1 3 3 3 0 SlyX CENP-H PF05837.12 KOO23435.1 - 10 6.6 14.5 1.3e+02 3.0 13.8 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) WD40 PF00400.32 KOO23436.1 - 1.3e-09 38.5 13.7 0.00085 20.1 0.3 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO23436.1 - 2.9e-07 30.7 0.0 2 8.8 0.0 5.4 2 2 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain DUF2201_N PF13203.6 KOO23438.1 - 1.1 8.8 16.0 1.2 8.7 16.0 1.0 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF2058 PF09831.9 KOO23438.1 - 2.9 8.0 19.1 3.2 7.9 19.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) Rtf2 PF04641.12 KOO23438.1 - 6.9 5.9 20.3 7.3 5.9 20.3 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger MAPKK1_Int PF08923.10 KOO23439.1 - 4.7e-18 65.1 0.0 5.2e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting MCM PF00493.23 KOO23440.1 - 8.2e-103 342.3 0.0 1.5e-102 341.5 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOO23440.1 - 6.3e-31 106.8 0.4 1.1e-30 106.1 0.4 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOO23440.1 - 4.2e-17 62.3 0.6 1.5e-16 60.6 0.6 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KOO23440.1 - 4.4e-15 56.1 0.4 1.2e-14 54.7 0.4 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KOO23440.1 - 3.2e-08 33.2 0.2 2.5e-05 23.8 0.0 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOO23440.1 - 1.3e-07 31.7 0.0 4.1e-07 30.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KOO23440.1 - 0.00031 20.6 0.1 0.00086 19.2 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 KOO23440.1 - 0.0065 16.9 0.7 0.51 10.8 0.1 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 KOO23440.1 - 0.017 14.9 0.2 0.017 14.9 0.2 2.3 3 0 0 3 3 3 0 AAA lid domain MMR_HSR1 PF01926.23 KOO23440.1 - 0.061 13.4 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase Sigma54_activat PF00158.26 KOO23440.1 - 0.12 12.0 0.3 0.93 9.2 0.0 2.3 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_16 PF13191.6 KOO23440.1 - 0.23 11.8 0.1 0.23 11.8 0.1 2.9 3 2 0 3 3 3 0 AAA ATPase domain Mg_chelatase_C PF13335.6 KOO23440.1 - 0.29 11.8 5.1 0.84 10.3 0.3 3.4 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI C-terminal DEAD PF00270.29 KOO23441.1 - 7e-44 149.7 0.0 9.7e-44 149.2 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO23441.1 - 1.1e-27 96.6 0.2 3.9e-27 94.8 0.2 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CFAP91 PF14738.6 KOO23442.1 - 9.7e-52 175.1 5.4 9.7e-52 175.1 5.4 3.3 2 1 0 3 3 3 1 Cilia- and flagella-associated protein 91 EPL1 PF10513.9 KOO23443.1 - 0.00027 21.4 0.0 0.00071 20.0 0.0 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-A20 PF01754.16 KOO23444.1 - 2.3e-11 43.4 7.5 6.6e-11 41.9 7.5 1.9 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.16 KOO23444.1 - 8.4e-08 32.3 9.3 8.4e-08 32.3 9.3 1.9 2 0 0 2 2 2 1 AN1-like Zinc finger FAP PF07174.11 KOO23444.1 - 0.93 8.9 18.7 1.2 8.5 18.7 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DEC-1_N PF04625.13 KOO23444.1 - 1.2 8.1 15.2 2.1 7.3 15.2 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region PRKCSH-like PF12999.7 KOO23445.1 - 6.3e-36 123.8 0.3 1.4e-35 122.6 0.3 1.6 1 0 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 KOO23445.1 - 1.5e-26 92.9 0.0 2.3e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 KOO23445.1 - 0.0005 21.0 1.4 0.0005 21.0 1.4 2.5 2 2 0 2 2 2 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 KOO23445.1 - 0.022 14.6 0.3 0.039 13.8 0.3 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 Ldl_recept_a PF00057.18 KOO23445.1 - 0.036 14.3 7.5 0.32 11.2 1.6 2.8 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A PDDEXK_9 PF08011.11 KOO23445.1 - 0.14 12.0 0.2 0.27 11.2 0.2 1.4 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Adaptin_N PF01602.20 KOO23446.1 - 1.5e-94 317.4 6.5 2.1e-94 317.0 6.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 KOO23446.1 - 9.2e-57 190.5 0.0 2.2e-56 189.3 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 KOO23446.1 - 7.8e-51 171.7 0.2 1.7e-50 170.5 0.2 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Cnd1 PF12717.7 KOO23446.1 - 3.9e-08 33.5 4.5 9e-07 29.1 0.7 2.5 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOO23446.1 - 3.2e-05 24.3 0.2 0.036 14.4 0.0 4.3 1 1 2 4 4 4 1 HEAT repeats HEAT PF02985.22 KOO23446.1 - 0.00099 19.2 3.1 0.1 12.9 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat Coatomer_g_Cpla PF16381.5 KOO23446.1 - 0.0049 17.0 0.0 0.019 15.1 0.0 2.1 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform ParcG PF10274.9 KOO23446.1 - 0.0098 16.0 2.8 4.4 7.4 0.4 3.4 3 1 1 4 4 4 2 Parkin co-regulated protein DUF5578 PF17741.1 KOO23446.1 - 0.047 13.1 4.2 0.68 9.3 0.9 2.9 1 1 2 3 3 3 0 Family of unknown function (DUF5578) Herpes_U44 PF04533.13 KOO23446.1 - 0.21 11.1 3.0 0.39 10.3 0.5 2.2 1 1 1 2 2 2 0 Herpes virus U44 protein WD40 PF00400.32 KOO23447.1 - 1.4e-65 215.6 27.0 5.9e-09 36.4 0.5 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO23447.1 - 1.9e-22 79.7 6.8 0.0083 15.1 0.0 7.1 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO23447.1 - 1.8e-18 66.6 6.8 0.062 13.6 0.0 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO23447.1 - 5.5e-14 51.7 1.7 1.2 9.1 0.0 7.8 8 0 0 8 8 8 5 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO23447.1 - 4.8e-12 45.0 0.0 0.0028 16.1 0.0 4.5 1 1 3 4 4 4 4 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KOO23447.1 - 5e-12 46.1 1.2 0.0087 16.0 0.0 3.9 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 KOO23447.1 - 9.2e-08 32.1 0.5 0.06 13.4 0.0 5.2 1 1 4 6 6 6 3 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 KOO23447.1 - 2.5e-06 27.0 7.4 3 7.1 0.1 5.7 1 1 5 6 6 6 2 Neuroblastoma-amplified sequence, N terminal DUF1513 PF07433.11 KOO23447.1 - 6.8e-06 25.4 0.6 0.55 9.3 0.1 4.1 1 1 4 5 5 5 3 Protein of unknown function (DUF1513) DCX PF03607.17 KOO23447.1 - 0.0002 21.4 0.0 12 6.1 0.0 5.9 7 0 0 7 7 7 1 Doublecortin Plk4_PB1 PF18190.1 KOO23447.1 - 0.00022 21.4 0.2 4 7.6 0.0 4.7 2 2 4 6 6 6 1 Polo-like Kinase 4 Polo Box 1 Dfp1_Him1_M PF08630.10 KOO23447.1 - 0.00054 20.2 9.3 17 5.6 0.0 6.6 7 0 0 7 7 7 0 Dfp1/Him1, central region Utp8 PF10395.9 KOO23447.1 - 0.0017 17.0 2.1 0.59 8.6 0.1 3.6 1 1 3 4 4 4 2 Utp8 family rOmpB PF12334.8 KOO23447.1 - 0.0057 16.1 6.4 9.2 5.7 0.1 5.6 1 1 6 7 7 7 1 Rickettsia outer membrane protein B WD40_3 PF15911.5 KOO23447.1 - 0.12 12.4 4.3 57 3.8 0.0 5.2 6 0 0 6 6 6 0 WD domain, G-beta repeat Methyltransf_16 PF10294.9 KOO23448.1 - 0.00033 20.4 0.0 0.00084 19.1 0.0 1.6 1 1 0 1 1 1 1 Lysine methyltransferase PH PF00169.29 KOO23449.1 - 2.7e-10 40.7 0.0 7.1e-10 39.3 0.0 1.7 1 1 0 1 1 1 1 PH domain CobS PF02654.15 KOO23449.1 - 0.0083 16.3 0.7 0.0083 16.3 0.7 1.5 2 0 0 2 2 2 1 Cobalamin-5-phosphate synthase DUF2244 PF10003.9 KOO23449.1 - 0.057 13.1 2.1 0.13 11.9 2.1 1.6 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Orai-1 PF07856.12 KOO23449.1 - 0.06 13.0 9.1 0.22 11.2 9.1 1.7 1 1 0 1 1 1 0 Mediator of CRAC channel activity PH_11 PF15413.6 KOO23449.1 - 0.066 13.6 0.0 0.2 12.1 0.0 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain Bestrophin PF01062.21 KOO23452.1 - 5.5e-19 68.7 0.0 2.8e-15 56.5 0.0 2.4 2 1 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel Mesd PF10185.9 KOO23452.1 - 1e-08 35.3 9.0 9.7e-07 28.8 9.0 2.3 1 1 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor Ribosomal_L38e PF01781.18 KOO23453.1 - 3.8e-35 119.8 6.0 4.1e-35 119.7 6.0 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Glyco_trans_1_4 PF13692.6 KOO23454.1 - 6.2e-10 39.6 0.0 1.4e-09 38.5 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KOO23454.1 - 5.4e-05 23.5 0.0 0.0001 22.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 NIF PF03031.18 KOO23455.1 - 7.9e-17 61.5 0.0 9.4e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase NHS PF15273.6 KOO23457.1 - 0.023 13.8 0.1 0.031 13.4 0.1 1.1 1 0 0 1 1 1 0 NHS-like CRAL_TRIO PF00650.20 KOO23458.1 - 1.5e-15 57.3 0.0 2.3e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain EF-hand_1 PF00036.32 KOO23458.1 - 1.6e-12 46.0 0.1 4e-06 26.0 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO23458.1 - 9.5e-09 35.6 0.1 8.3e-07 29.4 0.0 2.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO23458.1 - 2.2e-08 33.2 0.1 0.0086 15.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO23458.1 - 1.7e-07 30.9 0.1 6.6e-07 29.1 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO23458.1 - 4.7e-07 29.2 0.0 0.037 13.9 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_9 PF14658.6 KOO23458.1 - 0.00045 20.5 0.0 0.00092 19.5 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain Dockerin_1 PF00404.18 KOO23458.1 - 0.068 13.4 0.2 0.14 12.4 0.2 1.4 1 0 0 1 1 1 0 Dockerin type I domain DUF3248 PF11609.8 KOO23459.1 - 0.064 13.2 0.1 0.19 11.6 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3248) bZIP_2 PF07716.15 KOO23459.1 - 0.13 12.4 9.9 0.22 11.6 9.9 1.4 1 0 0 1 1 1 0 Basic region leucine zipper DUF1501 PF07394.12 KOO23459.1 - 0.19 10.8 0.9 0.26 10.3 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Tex_N PF09371.10 KOO23460.1 - 0.079 12.6 0.0 0.083 12.6 0.0 1.1 1 0 0 1 1 1 0 Tex-like protein N-terminal domain SNF2_N PF00176.23 KOO23461.1 - 7.6e-71 238.6 0.0 1.2e-70 238.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 KOO23461.1 - 1.7e-39 134.4 0.4 6.1e-39 132.6 0.4 2.0 1 0 0 1 1 1 1 SLIDE Helicase_C PF00271.31 KOO23461.1 - 4.3e-21 75.3 0.0 3.4e-19 69.2 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO23461.1 - 2e-09 37.7 0.4 1.6e-08 34.7 0.0 2.9 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 KOO23461.1 - 2e-09 37.5 0.7 0.00016 21.8 0.2 3.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain HDA2-3 PF11496.8 KOO23461.1 - 9.1e-07 28.3 0.0 1.9e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 KOO23461.1 - 7.8e-06 25.8 0.0 1.7e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HMG_box PF00505.19 KOO23461.1 - 0.0017 18.8 4.3 0.0081 16.6 4.3 2.4 1 0 0 1 1 1 1 HMG (high mobility group) box SWI2_SNF2 PF18766.1 KOO23461.1 - 0.0034 17.1 0.0 0.0078 15.9 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF2605 PF10792.9 KOO23461.1 - 0.14 12.1 1.7 0.42 10.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2605) RRM_1 PF00076.22 KOO23462.1 - 4.4e-16 58.4 0.0 6.8e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KOO23462.1 - 0.0053 16.8 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif Phage_TAC_13 PF16459.5 KOO23462.1 - 0.1 13.1 0.1 24 5.4 0.0 2.3 2 0 0 2 2 2 0 Phage tail assembly chaperone, TAC Dimer_Tnp_hAT PF05699.14 KOO23463.1 - 0.00056 19.6 0.0 0.00089 19.0 0.0 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Spc7_N PF15402.6 KOO23464.1 - 2.9 6.0 12.2 4.4 5.4 12.2 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 PDT PF00800.18 KOO23465.1 - 1.1e-09 38.4 0.0 3.6e-09 36.7 0.0 1.8 2 0 0 2 2 2 1 Prephenate dehydratase ACT PF01842.25 KOO23465.1 - 8.6e-06 25.4 0.1 3e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 ACT domain ACT_4 PF13291.6 KOO23465.1 - 0.12 12.9 0.0 0.44 11.2 0.0 1.9 2 0 0 2 2 2 0 ACT domain ACT_5 PF13710.6 KOO23465.1 - 0.16 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 ACT domain ACT_6 PF13740.6 KOO23465.1 - 0.26 11.3 1.2 1.4 8.9 0.0 2.8 4 0 0 4 4 4 0 ACT domain Gemin7 PF11095.8 KOO23465.1 - 0.26 11.2 1.2 4.1 7.4 0.3 2.9 3 0 0 3 3 3 0 Gem-associated protein 7 (Gemin7) Pkinase PF00069.25 KOO23466.1 - 8.2e-72 241.7 0.0 1.5e-71 240.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23466.1 - 9.3e-51 172.6 0.0 2.5e-50 171.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO23466.1 - 1.5e-06 27.3 0.0 2.4e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DRIM PF07539.12 KOO23466.1 - 0.0003 19.2 2.2 0.0004 18.8 0.1 2.1 2 0 0 2 2 2 1 Down-regulated in metastasis Kinase-like PF14531.6 KOO23466.1 - 0.0027 17.1 0.0 0.0063 15.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KOO23466.1 - 0.034 13.7 0.0 0.092 12.3 0.0 1.7 1 0 0 1 1 1 0 RIO1 family Arm PF00514.23 KOO23466.1 - 0.048 13.7 3.6 39 4.5 0.1 5.1 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Proteasome PF00227.26 KOO23467.1 - 3.3e-57 193.1 0.2 5.2e-57 192.4 0.2 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOO23467.1 - 6.8e-14 51.2 0.1 1.3e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Lipase_GDSL_2 PF13472.6 KOO23468.1 - 4.6e-09 36.9 0.0 5.9e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KOO23468.1 - 3.4e-08 33.7 0.0 4.3e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Adeno_PX PF05829.12 KOO23468.1 - 0.0025 17.6 0.1 0.0041 17.0 0.1 1.3 1 0 0 1 1 1 1 Adenovirus late L2 mu core protein (Protein X) Ion_trans PF00520.31 KOO23469.1 - 7.5e-25 87.6 7.5 1e-24 87.1 7.5 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO23469.1 - 2.5e-09 37.0 1.7 2.5e-09 37.0 1.7 2.7 3 0 0 3 3 3 1 Ion channel FliMN_C PF01052.20 KOO23469.1 - 0.14 12.2 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 Type III flagellar switch regulator (C-ring) FliN C-term Mem_trans PF03547.18 KOO23471.1 - 3.4e-14 52.1 9.7 4.2e-14 51.7 9.7 1.1 1 0 0 1 1 1 1 Membrane transport protein EF-hand_6 PF13405.6 KOO23472.1 - 5.7e-18 63.3 8.5 1e-05 25.1 0.0 5.5 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 KOO23472.1 - 6.1e-18 63.0 12.0 1e-06 27.9 0.2 5.5 5 1 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 KOO23472.1 - 5.9e-15 55.5 6.6 5.6e-06 26.7 0.5 4.2 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO23472.1 - 1.1e-11 43.7 9.9 0.00022 20.6 0.2 4.5 5 1 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO23472.1 - 1.4e-08 34.5 8.6 0.00081 19.2 0.5 4.8 4 1 1 5 5 5 3 EF-hand domain pair TCR PF03638.15 KOO23473.1 - 7.6e-22 77.3 51.4 8.5e-11 42.0 26.4 2.4 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 KOO23473.1 - 2.2 8.5 47.4 7.7 6.7 18.6 3.0 2 1 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 TolA_bind_tri PF16331.5 KOO23474.1 - 0.014 15.5 2.3 0.028 14.5 2.3 1.4 1 0 0 1 1 1 0 TolA binding protein trimerisation Methyltransf_24 PF13578.6 KOO23475.1 - 0.0012 19.8 0.0 0.0041 18.1 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Pyr_redox_2 PF07992.14 KOO23476.1 - 4.9e-06 26.0 0.0 8.8e-05 21.9 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO23476.1 - 0.0013 19.2 0.0 0.0046 17.5 0.0 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO23476.1 - 0.0017 17.1 0.1 0.0032 16.3 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 KOO23476.1 - 0.0029 17.8 0.0 0.0067 16.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOO23476.1 - 0.0098 15.2 0.6 0.016 14.5 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOO23476.1 - 0.011 15.0 0.9 0.081 12.2 0.5 2.5 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 KOO23476.1 - 0.022 14.0 1.5 0.27 10.4 0.2 2.8 2 1 0 2 2 2 0 FAD binding domain DAO PF01266.24 KOO23476.1 - 0.029 14.0 1.5 0.54 9.8 0.1 2.8 1 1 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOO23476.1 - 0.056 12.5 2.2 0.096 11.7 0.1 2.4 3 0 0 3 3 3 0 FAD binding domain FAD_oxidored PF12831.7 KOO23476.1 - 2.3 7.5 6.9 3.4 6.9 0.0 3.0 3 1 0 3 3 3 0 FAD dependent oxidoreductase LSM PF01423.22 KOO23477.1 - 2.5e-15 55.9 0.0 3.8e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOO23477.1 - 0.026 14.7 0.0 0.053 13.7 0.0 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain Erythro-docking PF09277.11 KOO23477.1 - 0.075 13.0 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 Erythronolide synthase, docking PTCB-BRCT PF12738.7 KOO23478.1 - 0.00059 19.7 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain Trypsin_2 PF13365.6 KOO23479.1 - 1.6e-32 113.5 0.8 3.1e-32 112.5 0.8 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 KOO23479.1 - 6.8e-18 65.3 0.1 1.1e-17 64.6 0.1 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 KOO23479.1 - 3.7e-13 49.6 0.1 4.2e-12 46.2 0.0 2.5 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KOO23479.1 - 1.9e-07 30.8 0.8 1.8e-05 24.5 0.1 2.6 2 0 0 2 2 2 1 PDZ domain Peptidase_S46 PF10459.9 KOO23479.1 - 7.6e-06 24.9 0.8 0.011 14.5 0.2 2.1 2 0 0 2 2 2 2 Peptidase S46 LSM PF01423.22 KOO23479.1 - 0.0011 18.6 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 LSM domain PDZ PF00595.24 KOO23479.1 - 0.0028 18.0 0.1 0.22 11.9 0.0 2.7 2 0 0 2 2 2 1 PDZ domain Peptidase_S32 PF05579.13 KOO23479.1 - 0.015 14.5 1.3 0.69 9.1 0.0 2.2 1 1 1 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Hfq PF17209.3 KOO23479.1 - 0.025 14.2 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Hfq protein Peptidase_S29 PF02907.15 KOO23479.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Exostosin PF03016.15 KOO23480.1 - 4.8e-12 45.7 0.0 6.2e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 Exostosin family EF-hand_1 PF00036.32 KOO23481.1 - 0.00014 21.2 0.0 0.00041 19.7 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO23481.1 - 0.00089 19.0 0.0 0.0036 17.1 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO23481.1 - 0.0093 15.4 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO23481.1 - 0.017 15.6 0.0 0.038 14.4 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair NIF3 PF01784.18 KOO23482.1 - 1.1e-35 123.5 0.0 1.3e-35 123.2 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Phageshock_PspD PF09584.10 KOO23482.1 - 0.051 13.6 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Phage shock protein PspD (Phageshock_PspD) Bax1-I PF01027.20 KOO23483.1 - 4.5e-35 121.4 37.5 4.5e-35 121.4 37.5 2.0 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 NAD_binding_2 PF03446.15 KOO23484.1 - 1.2e-32 113.3 0.9 1.9e-32 112.6 0.9 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KOO23484.1 - 1.9e-21 76.6 0.5 6.2e-21 74.9 0.0 2.1 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 KOO23484.1 - 9.7e-05 21.8 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KOO23484.1 - 0.00019 22.0 0.3 0.00042 20.8 0.3 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 KOO23484.1 - 0.00028 20.8 0.5 0.00047 20.1 0.5 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 KOO23484.1 - 0.0019 17.8 0.1 0.0032 17.0 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_C PF03720.15 KOO23484.1 - 0.0071 16.7 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 KOO23484.1 - 0.086 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Thymidylat_synt PF00303.19 KOO23485.1 - 0.00011 21.4 0.0 0.00022 20.4 0.0 1.4 1 1 0 1 1 1 1 Thymidylate synthase Exostosin PF03016.15 KOO23486.1 - 5.7e-07 29.0 0.0 6.8e-07 28.8 0.0 1.0 1 0 0 1 1 1 1 Exostosin family Redoxin PF08534.10 KOO23488.1 - 2.7e-20 72.6 0.0 3.6e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KOO23488.1 - 0.0094 15.9 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family P22_CoatProtein PF11651.8 KOO23488.1 - 0.047 12.3 0.2 0.066 11.8 0.2 1.2 1 0 0 1 1 1 0 P22 coat protein - gene protein 5 PARG_cat PF05028.14 KOO23489.1 - 2.8e-40 138.7 0.0 4.2e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Fcf2 PF08698.11 KOO23490.1 - 2.8e-29 101.3 0.1 4.3e-29 100.8 0.1 1.3 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing DUF1523 PF07509.11 KOO23490.1 - 0.11 11.9 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) Peptidase_M24 PF00557.24 KOO23491.1 - 4e-46 157.4 0.0 7.8e-46 156.4 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 KOO23491.1 - 4.3e-23 81.4 0.0 9.6e-23 80.2 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain FAD_binding_3 PF01494.19 KOO23491.1 - 7.5e-09 35.3 0.0 1.1e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 KOO23491.1 - 0.004 16.2 0.0 0.0095 15.0 0.0 1.5 2 0 0 2 2 2 1 Squalene epoxidase SCHIP-1 PF10148.9 KOO23492.1 - 0.012 15.3 2.1 0.013 15.1 2.1 1.1 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 Herpes_BLRF2 PF05812.12 KOO23492.1 - 0.056 13.6 0.8 0.056 13.6 0.8 2.1 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein Peptidase_S49_N PF08496.10 KOO23492.1 - 0.072 13.2 3.7 0.087 12.9 3.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SlyX PF04102.12 KOO23492.1 - 0.12 13.0 6.7 1.8 9.2 3.6 2.1 1 1 1 2 2 2 0 SlyX DivIC PF04977.15 KOO23492.1 - 0.14 12.0 11.0 0.61 9.9 0.1 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF2730 PF10805.8 KOO23492.1 - 0.39 10.8 4.1 0.77 9.9 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Atg14 PF10186.9 KOO23492.1 - 2 7.5 8.5 2.4 7.2 8.5 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_6 PF12774.7 KOO23494.1 - 1.1e-104 350.0 0.0 2.2e-93 312.8 0.0 4.0 3 1 0 3 3 3 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO23494.1 - 2e-98 330.1 2.5 2e-98 330.1 2.5 2.2 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO23494.1 - 7.6e-93 310.6 0.0 2.7e-92 308.8 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KOO23494.1 - 2.3e-81 272.1 0.2 5.5e-81 270.9 0.2 1.7 1 0 0 1 1 1 1 ATP-binding dynein motor region Dynein_C PF18199.1 KOO23494.1 - 1e-62 212.2 0.0 1.8e-62 211.4 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 KOO23494.1 - 3.8e-58 196.0 0.8 6.1e-56 188.8 0.0 3.4 4 0 0 4 4 4 1 P-loop containing dynein motor region MT PF12777.7 KOO23494.1 - 4.4e-58 197.0 13.2 8.7e-58 196.0 13.2 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 KOO23494.1 - 2.2e-40 138.2 0.0 1.2e-39 135.7 0.0 2.1 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO23494.1 - 2.8e-33 114.6 0.0 1.4e-30 105.8 0.0 3.0 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain Kelch_3 PF13415.6 KOO23494.1 - 2.4e-26 91.5 12.2 0.00011 22.4 0.0 8.1 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO23494.1 - 1.3e-25 89.1 14.6 1e-07 31.9 0.0 7.3 5 1 1 6 6 6 6 Galactose oxidase, central domain AAA_lid_1 PF17857.1 KOO23494.1 - 2.2e-24 85.5 0.0 1.9e-23 82.6 0.0 2.5 2 0 0 2 2 2 1 AAA+ lid domain Kelch_5 PF13854.6 KOO23494.1 - 8.8e-21 73.5 2.0 0.0018 18.2 0.0 7.8 7 0 0 7 7 7 4 Kelch motif Dynein_AAA_lid PF17852.1 KOO23494.1 - 1.1e-18 67.6 0.4 2.6e-18 66.3 0.4 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO23494.1 - 2.8e-17 63.0 0.2 1.1e-07 31.9 0.0 5.1 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Filamin PF00630.19 KOO23494.1 - 2.7e-12 47.4 0.0 6.3e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat Kelch_6 PF13964.6 KOO23494.1 - 9.3e-12 44.8 5.9 0.018 15.3 0.1 6.5 6 0 0 6 6 5 3 Kelch motif Kelch_1 PF01344.25 KOO23494.1 - 3.3e-11 42.6 7.0 0.018 14.6 0.8 5.8 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KOO23494.1 - 3.5e-10 39.4 13.3 0.27 11.3 0.1 7.6 7 0 0 7 7 7 3 Kelch motif TIG PF01833.24 KOO23494.1 - 6.8e-07 29.3 0.1 2e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 IPT/TIG domain AAA_22 PF13401.6 KOO23494.1 - 0.0078 16.5 0.1 5.7 7.2 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KOO23494.1 - 0.019 15.4 0.8 10 6.5 0.0 4.3 4 0 0 4 4 3 0 AAA ATPase domain AAA PF00004.29 KOO23494.1 - 0.03 14.8 0.0 6.5 7.2 0.0 3.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Glyco_tran_28_C PF04101.16 KOO23495.1 - 2.3e-11 44.0 0.0 8.9e-09 35.5 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 28 C-terminal domain O-FucT PF10250.9 KOO23496.1 - 4.8e-21 75.8 0.0 2.3e-15 57.1 0.0 2.2 2 0 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase TPR_2 PF07719.17 KOO23496.1 - 1.3e-09 37.4 15.6 0.001 19.0 0.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23496.1 - 3.4e-07 29.8 4.3 0.16 12.1 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23496.1 - 9.5e-06 26.0 7.5 0.00015 22.2 0.7 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23496.1 - 1.6e-05 24.5 2.1 2.3 8.2 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23496.1 - 0.00021 21.9 4.1 0.00021 21.9 4.1 6.0 4 1 4 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23496.1 - 0.00044 20.8 30.6 0.086 13.7 2.9 5.5 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23496.1 - 0.0024 18.1 22.5 0.034 14.4 6.1 4.3 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23496.1 - 0.0039 16.8 0.4 1.5 8.6 0.0 3.2 1 1 1 2 2 2 2 TPR repeat TPR_10 PF13374.6 KOO23496.1 - 0.089 12.7 13.6 2.1 8.4 0.4 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO23496.1 - 0.12 12.8 0.1 19 5.9 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO23496.1 - 1.5 9.6 4.6 91 4.0 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 KOO23497.1 - 1.2e-29 103.2 2.0 2.6e-28 98.8 2.0 2.2 1 1 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 KOO23497.1 - 0.059 12.8 0.5 0.19 11.1 0.5 1.9 1 1 0 1 1 1 0 SAC3/GANP family FtsJ PF01728.19 KOO23497.1 - 0.16 12.1 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase AAA_27 PF13514.6 KOO23498.1 - 0.017 14.7 0.1 0.019 14.6 0.1 1.1 1 0 0 1 1 1 0 AAA domain RuBisCO_large_N PF02788.16 KOO23498.1 - 0.15 12.3 0.1 0.19 11.9 0.1 1.2 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain PPR_2 PF13041.6 KOO23499.1 - 8.6e-54 179.5 0.0 3.8e-08 33.4 0.0 13.9 8 5 7 15 15 15 11 PPR repeat family PPR PF01535.20 KOO23499.1 - 6.4e-43 142.0 17.2 2.9e-05 24.0 0.0 17.1 19 0 0 19 19 18 6 PPR repeat PPR_3 PF13812.6 KOO23499.1 - 7.1e-40 134.9 0.0 3.6e-08 33.4 0.0 10.5 10 3 1 12 12 12 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 KOO23499.1 - 3.1e-31 106.8 0.0 2.5e-06 27.1 0.0 11.8 14 0 0 14 14 14 7 PPR repeat PPR_long PF17177.4 KOO23499.1 - 1.4e-29 103.0 17.4 4.3e-08 32.8 0.0 6.0 2 1 3 6 6 6 5 Pentacotripeptide-repeat region of PRORP TPR_7 PF13176.6 KOO23499.1 - 6.5e-05 22.7 23.2 1.4 9.1 0.1 10.9 14 0 0 14 14 12 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO23499.1 - 0.00014 22.0 3.5 2 8.7 0.0 5.0 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KOO23499.1 - 0.00088 19.7 30.2 0.065 13.7 0.3 8.3 7 2 1 8 8 8 2 Tetratricopeptide repeat Clathrin PF00637.20 KOO23499.1 - 0.01 15.7 0.0 44 3.9 0.0 5.3 7 0 0 7 7 7 0 Region in Clathrin and VPS Methyltransf_25 PF13649.6 KOO23499.1 - 0.042 14.6 0.3 0.31 11.8 0.1 2.5 1 1 1 2 2 2 0 Methyltransferase domain MOZART1 PF12554.8 KOO23499.1 - 0.12 12.1 0.1 39 4.1 0.0 3.3 4 0 0 4 4 4 0 Mitotic-spindle organizing gamma-tubulin ring associated TENA_THI-4 PF03070.16 KOO23499.1 - 0.79 9.5 5.8 1.6 8.5 0.2 4.0 4 1 1 5 5 5 0 TENA/THI-4/PQQC family TPR_2 PF07719.17 KOO23499.1 - 4.6 7.6 13.0 79 3.7 0.1 7.3 9 0 0 9 9 8 0 Tetratricopeptide repeat SET PF00856.28 KOO23500.1 - 9e-07 29.4 0.0 1.4e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 SET domain Rad51 PF08423.11 KOO23502.1 - 3.4e-120 400.0 0.1 4.3e-120 399.7 0.1 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 KOO23502.1 - 5.8e-11 42.4 0.1 8.1e-11 41.9 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 KOO23502.1 - 2.3e-07 30.4 0.1 5.6e-07 29.1 0.1 1.6 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 KOO23502.1 - 4.5e-07 29.7 0.0 6.6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 KOO23502.1 - 4.3e-05 24.0 1.4 7.2e-05 23.3 0.4 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain RNA_pol_A_CTD PF03118.15 KOO23502.1 - 0.017 14.9 0.5 0.035 13.9 0.1 1.6 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain AAA_24 PF13479.6 KOO23502.1 - 0.04 13.6 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_membrane PF00664.23 KOO23503.1 - 4.2e-60 203.7 19.8 1.1e-35 123.7 4.1 2.8 4 0 0 4 4 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOO23503.1 - 3.5e-46 157.1 0.0 3.4e-26 92.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOO23503.1 - 1.1e-09 38.0 0.2 0.069 12.6 0.0 4.1 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOO23503.1 - 1.3e-07 31.7 0.8 0.67 9.7 0.0 4.3 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KOO23503.1 - 1.5e-06 28.7 1.5 0.01 16.2 0.1 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 KOO23503.1 - 2.9e-06 28.0 0.2 0.066 13.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 KOO23503.1 - 0.00014 21.9 0.2 0.6 10.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 KOO23503.1 - 0.00027 20.6 1.5 0.2 11.4 0.5 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO23503.1 - 0.00059 20.1 0.9 0.85 9.9 0.0 3.5 2 2 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KOO23503.1 - 0.0029 17.5 0.2 0.85 9.5 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase NB-ARC PF00931.22 KOO23503.1 - 0.0054 15.9 1.1 3.9 6.6 0.1 3.5 3 1 0 3 3 3 1 NB-ARC domain cobW PF02492.19 KOO23503.1 - 0.0084 15.7 1.3 0.31 10.6 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KOO23503.1 - 0.02 14.6 1.7 12 5.6 0.0 3.6 4 0 0 4 4 4 0 AAA domain TrwB_AAD_bind PF10412.9 KOO23503.1 - 0.041 12.8 0.4 2.9 6.7 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 KOO23503.1 - 0.07 12.2 0.5 1 8.4 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Dynamin_N PF00350.23 KOO23503.1 - 0.081 13.0 0.3 7.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Dynamin family AAA_18 PF13238.6 KOO23503.1 - 0.082 13.4 0.3 3.4 8.2 0.1 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KOO23503.1 - 0.12 11.7 0.2 12 5.1 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin ATP-synt_ab PF00006.25 KOO23503.1 - 0.17 11.6 0.0 8.3 6.0 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.6 KOO23503.1 - 0.35 10.4 3.9 1.4 8.5 0.1 3.1 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 KOO23503.1 - 0.62 10.1 1.7 1.6 8.8 0.2 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain SbcCD_C PF13558.6 KOO23503.1 - 0.93 9.8 8.2 17 5.7 0.1 4.8 4 1 0 4 4 3 0 Putative exonuclease SbcCD, C subunit UMPH-1 PF05822.12 KOO23504.1 - 2.7e-34 118.8 0.0 3.8e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.7 KOO23504.1 - 2.1e-12 47.9 0.1 4.6e-12 46.7 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOO23504.1 - 0.0026 17.9 0.0 0.4 10.8 0.0 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 KOO23504.1 - 0.0094 15.4 0.0 1.1 8.6 0.0 2.7 2 1 0 2 2 2 1 Putative Phosphatase Hydrolase PF00702.26 KOO23504.1 - 0.016 15.5 0.1 0.08 13.2 0.1 2.3 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Ion_trans PF00520.31 KOO23505.1 - 8e-202 667.1 72.1 2.8e-58 197.1 10.4 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO23505.1 - 6.6e-22 77.8 61.6 3.2e-12 45.9 0.3 9.9 7 3 1 10 10 10 8 Polycystin cation channel GPHH PF16905.5 KOO23505.1 - 1.2e-06 28.1 0.0 3e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Phage_30_8 PF06019.11 KOO23505.1 - 0.14 12.0 0.2 0.37 10.7 0.2 1.6 1 0 0 1 1 1 0 Phage GP30.8 protein Ninjurin PF04923.12 KOO23505.1 - 8.9 6.3 12.5 1.5 8.8 0.1 4.6 4 0 0 4 4 4 0 Ninjurin ATP-synt_A PF00119.20 KOO23506.1 - 0.0089 16.0 0.1 0.0092 16.0 0.1 1.0 1 0 0 1 1 1 1 ATP synthase A chain ADK PF00406.22 KOO23507.1 - 3.4e-43 147.3 0.0 4.7e-43 146.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO23507.1 - 2.2e-34 118.8 0.0 4e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO23507.1 - 1.6e-08 35.1 0.0 2.6e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO23507.1 - 2.4e-06 27.7 0.0 4.1e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 KOO23507.1 - 0.0027 17.4 0.0 0.32 10.6 0.0 2.3 2 0 0 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.12 KOO23507.1 - 0.069 12.4 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin GNT-I PF03071.15 KOO23508.1 - 9.7e-105 350.8 0.0 1.3e-104 350.3 0.0 1.1 1 0 0 1 1 1 1 GNT-I family Glycos_transf_2 PF00535.26 KOO23508.1 - 0.015 15.1 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KOO23508.1 - 0.017 15.0 0.1 0.13 12.1 0.1 2.3 1 1 0 1 1 1 0 Glycosyltransferase like family 2 SBP_bac_5 PF00496.22 KOO23508.1 - 0.094 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle MGAT2 PF05060.14 KOO23508.1 - 0.23 10.5 0.0 11 5.0 0.0 2.1 2 0 0 2 2 2 0 N-acetylglucosaminyltransferase II (MGAT2) 2OG-FeII_Oxy_3 PF13640.6 KOO23509.1 - 7.7e-17 62.0 0.0 1.2e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO23509.1 - 1.6e-05 25.3 0.1 4.2e-05 24.0 0.1 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily NAD_binding_10 PF13460.6 KOO23510.1 - 1.1e-33 116.7 0.0 1.3e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO23510.1 - 0.00012 21.7 0.2 0.002 17.7 0.2 2.5 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 KOO23510.1 - 0.003 16.6 0.0 0.0061 15.6 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 KOO23510.1 - 0.011 16.2 0.1 0.017 15.6 0.1 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 KOO23510.1 - 0.016 14.7 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 KOO23510.1 - 0.069 13.3 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.22 KOO23510.1 - 0.11 13.3 0.1 0.18 12.6 0.1 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold GDP_Man_Dehyd PF16363.5 KOO23510.1 - 0.26 10.7 0.0 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase UBA PF00627.31 KOO23511.1 - 5.4e-08 32.6 0.4 1.1e-07 31.6 0.4 1.5 1 0 0 1 1 1 1 UBA/TS-N domain CUE PF02845.16 KOO23511.1 - 0.016 14.9 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 CUE domain zf-RING_5 PF14634.6 KOO23511.1 - 0.016 15.1 1.6 0.037 14.0 1.6 1.6 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 KOO23511.1 - 0.018 14.7 0.8 0.036 13.8 0.8 1.5 1 0 0 1 1 1 0 RING-like zinc finger UIM PF02809.20 KOO23511.1 - 0.056 13.4 3.7 0.23 11.5 3.7 2.2 1 0 0 1 1 1 0 Ubiquitin interaction motif zf-C3H2C3 PF17122.5 KOO23511.1 - 0.066 13.3 0.3 0.14 12.2 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger UBA_5 PF16577.5 KOO23511.1 - 0.094 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 UBA domain zf-RING_2 PF13639.6 KOO23511.1 - 0.19 12.1 5.1 1 9.7 5.3 2.0 1 1 1 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 KOO23511.1 - 0.27 11.1 1.7 0.75 9.7 1.7 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO23511.1 - 0.7 9.8 3.1 0.41 10.6 0.8 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 KOO23511.1 - 5.5 7.0 7.0 37 4.3 3.8 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Asp PF00026.23 KOO23512.1 - 1.8e-24 86.8 0.0 5.8e-24 85.1 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO23512.1 - 4.4e-05 23.8 0.1 0.082 13.1 0.0 2.5 1 1 0 2 2 2 2 Xylanase inhibitor N-terminal EF-hand_1 PF00036.32 KOO23513.1 - 8.1e-34 112.7 0.7 0.0002 20.7 0.0 6.2 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.6 KOO23513.1 - 8.8e-34 113.5 3.8 3.2e-05 23.2 0.0 6.2 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO23513.1 - 1.6e-31 105.5 0.3 0.0014 18.4 0.0 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.6 KOO23513.1 - 1.8e-24 86.0 0.1 7.9e-07 29.4 0.0 3.9 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO23513.1 - 1.3e-17 63.4 4.5 0.0034 17.2 0.1 6.3 3 3 3 6 6 6 6 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO23513.1 - 4.1e-11 43.2 0.0 0.0053 17.1 0.0 3.6 3 1 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Toprim PF01751.22 KOO23513.1 - 0.0011 19.1 0.3 8.8 6.6 0.0 3.2 1 1 2 3 3 3 1 Toprim domain Dockerin_1 PF00404.18 KOO23513.1 - 0.0018 18.4 6.0 1.8 8.8 0.7 4.6 4 1 1 5 5 5 1 Dockerin type I domain TPR_20 PF14561.6 KOO23513.1 - 0.0057 17.0 1.7 0.63 10.4 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat EF-hand_14 PF17959.1 KOO23513.1 - 0.011 16.1 0.1 13 6.2 0.0 3.9 4 1 1 5 5 5 0 EF-hand domain EF-hand_9 PF14658.6 KOO23513.1 - 0.031 14.6 0.8 6.7 7.1 0.0 3.7 4 1 0 4 4 4 0 EF-hand domain EF-hand_13 PF17958.1 KOO23513.1 - 0.035 13.9 0.0 19 5.2 0.0 4.0 5 1 0 5 5 5 0 EF-hand domain OAM_dimer PF16554.5 KOO23513.1 - 0.1 13.1 0.0 4.5 7.8 0.0 2.6 2 0 0 2 2 2 0 Dimerisation domain of d-ornithine 4,5-aminomutase Arm-DNA-bind_1 PF09003.10 KOO23513.1 - 0.14 12.4 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage lambda integrase, Arm DNA-binding domain Ribosomal_L1 PF00687.21 KOO23514.1 - 1.7e-41 142.2 0.0 2.1e-41 141.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Tom22 PF04281.13 KOO23515.1 - 7e-05 22.6 0.0 8e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DUF4882 PF16223.5 KOO23517.1 - 0.19 10.9 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4882) Apt1 PF10351.9 KOO23519.1 - 0.1 11.4 0.2 0.14 10.9 0.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain TPR_19 PF14559.6 KOO23520.1 - 0.7 10.4 7.5 0.5 10.9 2.4 2.5 1 1 0 2 2 2 0 Tetratricopeptide repeat Polysacc_synt_C PF14667.6 KOO23521.1 - 2.5e-07 30.9 6.6 2.5e-07 30.9 6.6 3.6 3 1 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain MatE PF01554.18 KOO23521.1 - 0.00021 21.0 15.1 0.00021 21.0 15.1 3.3 3 1 0 3 3 3 2 MatE Pkinase PF00069.25 KOO23522.1 - 1.1e-49 169.2 0.0 1.2e-49 169.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23522.1 - 2.6e-20 72.8 0.0 3.2e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO23522.1 - 9.5e-08 32.3 0.6 0.0066 16.4 0.0 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO23522.1 - 2e-05 24.1 0.0 8.5e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO23522.1 - 2.3e-05 23.3 0.0 4.6e-05 22.4 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KOO23522.1 - 0.004 16.5 0.0 0.008 15.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOO23522.1 - 0.037 13.6 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase FTA2 PF13095.6 KOO23522.1 - 0.047 13.3 0.0 0.33 10.5 0.1 2.1 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RNA_pol_Rpb6 PF01192.22 KOO23524.1 - 1.7e-15 56.7 0.2 3.9e-15 55.5 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb6 HSP20 PF00011.21 KOO23524.1 - 9.8e-09 35.3 0.0 2.6e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 Hsp20/alpha crystallin family MMR_HSR1 PF01926.23 KOO23524.1 - 0.00016 21.7 0.1 0.00077 19.5 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GBP PF02263.19 KOO23524.1 - 0.00036 19.9 3.9 0.0029 16.9 0.1 2.2 1 1 1 2 2 2 2 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 KOO23524.1 - 0.0036 17.4 2.0 0.085 12.9 0.1 3.0 2 1 0 3 3 3 1 Dynamin family FeoB_N PF02421.18 KOO23524.1 - 0.09 12.3 0.1 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B DMA PF03474.14 KOO23524.1 - 0.21 11.2 0.6 0.39 10.3 0.1 1.7 2 0 0 2 2 2 0 DMRTA motif Ras PF00071.22 KOO23525.1 - 2.5e-50 170.2 0.0 3e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO23525.1 - 2.4e-31 108.4 0.1 6.6e-31 107.0 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO23525.1 - 5.5e-11 42.2 0.0 7.4e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO23525.1 - 3.5e-05 23.9 0.0 5.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOO23525.1 - 5.6e-05 22.6 0.0 7e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RNA_helicase PF00910.22 KOO23525.1 - 0.00017 22.0 0.2 0.0013 19.1 0.2 2.1 1 1 0 1 1 1 1 RNA helicase G-alpha PF00503.20 KOO23525.1 - 0.0026 17.0 1.9 1.2 8.2 0.1 2.8 2 1 1 3 3 3 2 G-protein alpha subunit RsgA_GTPase PF03193.16 KOO23525.1 - 0.0032 17.4 0.2 1.1 9.2 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOO23525.1 - 0.0036 16.9 0.3 0.015 14.8 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ArgoMid PF16487.5 KOO23525.1 - 0.016 15.4 0.1 0.03 14.6 0.1 1.5 1 0 0 1 1 1 0 Mid domain of argonaute Pox_A32 PF04665.12 KOO23525.1 - 0.038 13.4 0.1 0.065 12.7 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_16 PF13191.6 KOO23525.1 - 0.057 13.8 0.0 0.084 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 KOO23525.1 - 0.07 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 KOO23525.1 - 0.086 12.6 0.4 12 5.6 0.1 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 KOO23525.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 KOO23525.1 - 0.16 12.0 0.1 0.38 10.8 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KOO23525.1 - 0.2 11.8 0.1 0.38 10.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain Gelsolin PF00626.22 KOO23526.1 - 1.3e-14 53.9 0.0 0.0041 17.0 0.0 6.4 6 0 0 6 6 6 3 Gelsolin repeat cNMP_binding PF00027.29 KOO23526.1 - 5.7e-07 29.5 0.1 3e-06 27.2 0.1 2.3 3 0 0 3 3 3 1 Cyclic nucleotide-binding domain PH PF00169.29 KOO23526.1 - 0.00022 21.7 0.0 1.2 9.6 0.0 3.3 3 0 0 3 3 3 2 PH domain DUF3584 PF12128.8 KOO23526.1 - 3.1 5.2 17.5 4.3 4.7 17.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MAT1 PF06391.13 KOO23526.1 - 6.6 6.5 11.9 11 5.8 11.9 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 ILVD_EDD PF00920.21 KOO23527.1 - 1.6e-205 683.6 1.5 1.9e-205 683.4 1.5 1.0 1 0 0 1 1 1 1 Dehydratase family TrkA_N PF02254.18 KOO23527.1 - 0.11 12.7 0.1 0.32 11.3 0.1 1.7 2 0 0 2 2 2 0 TrkA-N domain Peptidase_C2 PF00648.21 KOO23528.1 - 1.5e-64 217.9 0.0 2.1e-64 217.4 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease RCC1 PF00415.18 KOO23528.1 - 2e-34 117.9 4.8 2.6e-10 40.7 0.2 6.7 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO23528.1 - 2.3e-15 55.9 15.3 0.0017 18.1 0.1 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Calpain_III PF01067.22 KOO23528.1 - 0.031 14.6 0.0 0.057 13.7 0.0 1.3 1 0 0 1 1 1 0 Calpain large subunit, domain III IQ PF00612.27 KOO23529.1 - 0.016 14.9 5.2 0.39 10.6 0.1 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif DUF3886 PF13025.6 KOO23529.1 - 0.49 10.6 8.0 0.26 11.5 5.9 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3886) Exo_endo_phos PF03372.23 KOO23530.1 - 6.2e-11 42.3 0.5 1.7e-10 40.9 0.5 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family STT3 PF02516.14 KOO23531.1 - 2.2e-61 208.3 17.7 6.2e-57 193.6 15.4 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT PF02366.18 KOO23531.1 - 0.004 16.8 6.7 0.0085 15.7 6.7 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase HCV_env PF01539.17 KOO23531.1 - 0.054 13.2 1.8 0.12 12.0 1.8 1.5 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 DUF2301 PF10063.9 KOO23531.1 - 0.55 10.7 2.7 33 4.9 0.1 3.4 4 0 0 4 4 4 0 Uncharacterized integral membrane protein (DUF2301) zf-CCCH PF00642.24 KOO23532.1 - 1e-18 66.7 23.1 3.2e-06 26.9 1.1 4.4 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOO23532.1 - 3.2e-18 65.1 38.6 8.5e-06 25.7 3.7 4.4 4 0 0 4 4 4 4 Zinc finger domain zf-CCCH_4 PF18044.1 KOO23532.1 - 8.8e-18 63.7 26.3 7.7e-07 28.8 1.2 4.4 4 0 0 4 4 4 4 CCCH-type zinc finger Torus PF16131.5 KOO23532.1 - 1.3e-09 38.7 21.3 0.056 14.1 0.3 4.5 2 2 2 4 4 4 4 Torus domain zf-CCCH_2 PF14608.6 KOO23532.1 - 1.9e-07 31.3 34.4 0.0052 17.2 3.2 4.3 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 KOO23532.1 - 6.6e-06 26.3 8.3 0.00073 19.7 0.8 2.9 2 1 0 2 2 2 2 Zinc-finger containing family EF-hand_5 PF13202.6 KOO23533.1 - 1.4e-141 454.4 134.2 5.3e-06 25.7 0.4 28.1 14 14 14 28 28 28 28 EF hand EF-hand_1 PF00036.32 KOO23533.1 - 1.3e-122 390.5 135.4 4.6e-06 25.8 0.3 28.1 10 10 18 28 28 28 28 EF hand EF-hand_6 PF13405.6 KOO23533.1 - 2.3e-115 366.9 132.6 3.3e-05 23.5 0.6 28.1 11 11 17 28 28 28 28 EF-hand domain EF-hand_7 PF13499.6 KOO23533.1 - 2.9e-89 293.6 98.6 4.4e-10 39.9 1.6 21.9 5 5 8 14 14 14 14 EF-hand domain pair EF-hand_8 PF13833.6 KOO23533.1 - 4.8e-58 192.8 125.9 0.0036 17.1 0.2 27.8 16 10 12 28 28 28 24 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO23533.1 - 2.2e-10 40.8 37.0 3.6 7.9 0.1 18.4 1 1 14 15 15 15 1 Secreted protein acidic and rich in cysteine Ca binding region SHOCT PF09851.9 KOO23533.1 - 2.7e-07 30.1 24.5 5 7.0 0.2 13.9 17 0 0 17 17 17 2 Short C-terminal domain EF-hand_4 PF12763.7 KOO23533.1 - 0.00025 21.0 39.0 0.17 11.8 0.3 12.2 3 3 13 17 17 17 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO23533.1 - 0.00059 20.0 52.9 0.36 11.1 0.0 17.8 16 5 4 20 20 20 1 Dockerin type I domain PMBR PF09373.10 KOO23533.1 - 0.0016 18.5 2.8 1.8e+02 2.5 0.0 9.0 13 0 0 13 13 13 0 Pseudomurein-binding repeat DUF2782 PF11191.8 KOO23533.1 - 0.0022 18.2 0.0 20 5.5 0.0 5.8 5 2 1 7 7 7 0 Protein of unknown function (DUF2782) CCD48 PF15799.5 KOO23533.1 - 0.048 12.0 2.5 19 3.4 0.1 4.9 5 0 0 5 5 5 0 Coiled-coil domain-containing protein 48 Fve PF09259.11 KOO23533.1 - 0.058 13.5 4.6 54 4.0 0.0 5.3 7 0 0 7 7 6 0 Fungal immunomodulatory protein Fve Caleosin PF05042.13 KOO23533.1 - 0.23 11.4 41.2 0.27 11.2 0.1 10.1 5 4 4 10 10 10 0 Caleosin related protein 2OG-FeII_Oxy_3 PF13640.6 KOO23534.1 - 5.1e-17 62.5 0.0 6.1e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO23534.1 - 6.8e-07 29.9 0.0 1.2e-06 29.1 0.0 1.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO23534.1 - 0.066 13.7 0.0 0.074 13.6 0.0 1.3 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Abhydrolase_2 PF02230.16 KOO23535.1 - 1.6e-16 60.8 0.0 2.5e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 KOO23535.1 - 0.0035 17.0 0.0 0.016 14.9 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 KOO23535.1 - 0.0075 15.8 0.1 3.2 7.2 0.1 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase family Esterase_phd PF10503.9 KOO23535.1 - 0.061 12.8 4.4 4.9 6.6 0.0 3.1 3 0 0 3 3 3 0 Esterase PHB depolymerase Chlorophyllase2 PF12740.7 KOO23535.1 - 0.11 11.4 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Exo_endo_phos PF03372.23 KOO23536.1 - 2.4e-08 33.8 0.0 3.9e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FumaraseC_C PF10415.9 KOO23536.1 - 0.061 13.7 0.1 0.54 10.7 0.3 2.2 2 0 0 2 2 2 0 Fumarase C C-terminus FAD-oxidase_C PF02913.19 KOO23537.1 - 3.7e-62 210.2 0.0 5.4e-62 209.7 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KOO23537.1 - 2.5e-35 121.3 0.6 5.1e-35 120.2 0.6 1.5 1 0 0 1 1 1 1 FAD binding domain PUA PF01472.20 KOO23538.1 - 0.032 14.2 0.2 0.035 14.1 0.2 1.2 1 0 0 1 1 1 0 PUA domain Ribosomal_60s PF00428.19 KOO23538.1 - 3.5 8.3 11.0 4.7 7.9 11.0 1.3 1 1 0 1 1 1 0 60s Acidic ribosomal protein MOSC PF03473.17 KOO23539.1 - 9.3e-05 22.5 0.0 0.00014 21.9 0.0 1.3 1 1 0 1 1 1 1 MOSC domain Ion_trans_2 PF07885.16 KOO23540.1 - 2.9e-26 91.2 11.1 7.2e-14 51.5 0.8 2.2 2 0 0 2 2 2 2 Ion channel EF-hand_6 PF13405.6 KOO23540.1 - 3.7e-06 26.4 1.2 0.0014 18.4 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO23540.1 - 0.00014 21.2 3.4 0.0097 15.4 0.0 3.3 3 1 0 3 3 3 1 EF hand Ion_trans PF00520.31 KOO23540.1 - 0.00014 21.2 11.5 0.002 17.4 0.6 2.4 2 1 0 2 2 2 2 Ion transport protein IRK PF01007.20 KOO23540.1 - 0.0011 18.7 0.7 0.66 9.8 0.1 2.4 2 0 0 2 2 2 2 Inward rectifier potassium channel transmembrane domain EF-hand_5 PF13202.6 KOO23540.1 - 0.0013 18.1 3.0 0.13 11.8 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO23540.1 - 0.0063 16.9 0.3 0.079 13.4 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain pair Phage_TAC_12 PF12363.8 KOO23540.1 - 0.014 15.8 0.6 0.023 15.1 0.6 1.3 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC DUF2207 PF09972.9 KOO23540.1 - 0.28 9.9 1.4 0.4 9.4 1.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EF-hand_1 PF00036.32 KOO23541.1 - 2.4e-14 51.7 1.2 8.3e-07 28.1 0.2 2.1 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO23541.1 - 3.3e-13 49.3 0.9 1.5e-08 34.4 0.2 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23541.1 - 1e-12 46.9 0.3 1.4e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO23541.1 - 1.4e-11 44.7 0.0 1.7e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO23541.1 - 1.6e-10 39.9 3.4 7e-06 25.3 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 KOO23541.1 - 0.0019 18.0 0.8 1.3 9.0 0.0 2.1 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO23541.1 - 0.11 12.8 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain DctA-YdbH PF11739.8 KOO23542.1 - 0.012 15.3 1.2 0.02 14.7 1.2 1.3 1 0 0 1 1 1 0 Dicarboxylate transport RecO_C PF02565.15 KOO23542.1 - 0.035 13.9 1.2 0.062 13.1 0.5 1.8 1 1 1 2 2 2 0 Recombination protein O C terminal IPK PF03770.16 KOO23542.1 - 0.18 11.6 4.1 0.24 11.2 4.1 1.3 1 0 0 1 1 1 0 Inositol polyphosphate kinase YkyA PF10368.9 KOO23542.1 - 0.44 10.2 24.4 0.075 12.7 6.4 2.1 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein Fez1 PF06818.15 KOO23542.1 - 1.2 9.5 22.0 3.5 8.0 21.7 1.7 1 1 0 1 1 1 0 Fez1 HIP1_clath_bdg PF16515.5 KOO23542.1 - 2.3 8.9 25.6 0.056 14.0 11.0 2.9 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cnn_1N PF07989.11 KOO23542.1 - 5.7 7.2 13.0 0.17 12.1 2.4 3.2 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 ART PF01129.18 KOO23544.1 - 1.2e-11 44.3 0.0 1.5e-11 44.0 0.0 1.0 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO23544.1 - 2.8e-06 26.8 0.0 3.6e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ABC2_membrane PF01061.24 KOO23546.1 - 1.2e-26 93.4 11.6 1.2e-26 93.4 11.6 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KOO23546.1 - 1.1e-23 84.2 0.0 1.8e-23 83.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOO23546.1 - 1.5e-07 31.5 0.1 0.0064 16.3 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KOO23546.1 - 0.001 19.0 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 KOO23546.1 - 0.0045 16.7 0.2 0.012 15.4 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 KOO23546.1 - 0.009 16.5 0.1 0.014 15.9 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO23546.1 - 0.019 15.3 0.2 0.046 14.1 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.19 KOO23546.1 - 0.021 14.3 0.0 1.5 8.2 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 KOO23546.1 - 0.032 14.0 0.3 0.067 12.9 0.3 1.6 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOO23546.1 - 0.09 12.3 0.1 0.19 11.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOO23546.1 - 0.1 12.9 0.1 0.28 11.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain ABC2_membrane_3 PF12698.7 KOO23546.1 - 0.34 10.0 15.2 0.96 8.5 14.9 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein EF-hand_1 PF00036.32 KOO23547.1 - 6.1e-13 47.3 2.2 3.4e-06 26.2 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO23547.1 - 1.1e-11 44.9 0.2 1.8e-11 44.3 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO23547.1 - 1.5e-10 40.1 0.4 6.9e-06 25.6 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO23547.1 - 1.1e-06 28.4 2.8 8.3e-05 22.4 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO23547.1 - 3.3e-05 23.2 1.0 0.014 14.9 0.1 2.5 2 0 0 2 2 2 2 EF hand Peptidase_S10 PF00450.22 KOO23548.1 - 5e-72 243.6 0.0 8.3e-70 236.3 0.0 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase MscS_porin PF12795.7 KOO23549.1 - 0.33 10.5 1.4 0.59 9.6 1.4 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain TPR_9 PF13371.6 KOO23550.1 - 9.4e-06 25.7 2.6 2.9e-05 24.1 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23550.1 - 0.00017 21.3 3.1 1.3 9.0 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23550.1 - 0.0016 18.4 3.3 0.74 10.1 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO23550.1 - 0.018 15.1 0.2 15 5.7 0.0 3.6 1 1 3 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 KOO23550.1 - 0.13 12.4 9.7 0.25 11.4 0.0 3.9 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 KOO23550.1 - 0.22 11.8 8.3 2.2 8.7 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23550.1 - 0.24 11.9 3.4 0.49 10.9 0.1 2.9 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23550.1 - 0.98 10.4 4.0 6.6 7.8 0.3 3.5 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO23550.1 - 1 10.1 5.1 1.8 9.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23550.1 - 1.4 9.6 4.7 2.4 8.9 0.2 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat UCH PF00443.29 KOO23552.1 - 4.5e-34 118.1 0.0 5.1e-34 117.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO23552.1 - 2.5e-15 56.9 0.0 3.2e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-4CXXC_R1 PF10497.9 KOO23552.1 - 0.032 14.4 2.8 0.32 11.3 2.5 2.3 2 1 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 ADD_ATRX PF17981.1 KOO23552.1 - 0.046 13.6 0.2 0.097 12.5 0.2 1.5 1 0 0 1 1 1 0 Cysteine Rich ADD domain Rubredoxin_2 PF18073.1 KOO23552.1 - 0.25 11.1 0.3 0.25 11.1 0.3 3.0 3 0 0 3 3 3 0 Rubredoxin metal binding domain EF-hand_1 PF00036.32 KOO23553.1 - 1.3e-12 46.3 1.0 6.8e-06 25.3 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO23553.1 - 4.9e-11 42.9 1.4 2.5e-10 40.7 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO23553.1 - 7.5e-11 41.7 0.9 6.8e-08 32.2 0.5 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23553.1 - 1e-10 40.7 4.4 0.00025 20.7 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KOO23553.1 - 8.3e-09 34.6 3.4 4.2e-05 22.9 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 KOO23553.1 - 0.1 12.4 0.4 25 4.8 0.0 3.0 3 0 0 3 3 3 0 EF hand zf-RING_2 PF13639.6 KOO23554.1 - 7.6e-08 32.6 11.4 1.3e-07 31.8 11.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOO23554.1 - 6.7e-06 25.9 10.9 1.2e-05 25.0 10.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO23554.1 - 4.1e-05 23.5 9.6 7.4e-05 22.7 9.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOO23554.1 - 5.6e-05 23.0 9.5 9.2e-05 22.3 9.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 KOO23554.1 - 0.00026 20.7 7.3 0.0017 18.0 7.3 2.2 1 1 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KOO23554.1 - 0.011 15.6 14.3 0.053 13.4 14.3 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.16 KOO23554.1 - 0.032 14.5 1.8 0.042 14.1 1.8 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger zf-rbx1 PF12678.7 KOO23554.1 - 0.035 14.4 12.6 0.087 13.1 12.6 1.6 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 KOO23554.1 - 0.039 13.8 5.7 0.12 12.3 5.7 1.8 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 KOO23554.1 - 0.13 12.3 7.4 0.31 11.1 7.3 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KOO23554.1 - 0.14 12.1 12.0 0.47 10.4 12.0 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KOO23554.1 - 0.34 10.7 8.4 0.7 9.7 8.4 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 KOO23554.1 - 1 9.2 5.0 1.8 8.5 5.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 KOO23554.1 - 1.5 8.8 10.2 3.5 7.6 10.2 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3H2C3 PF17122.5 KOO23554.1 - 1.6 8.9 12.9 6.6 6.9 13.0 2.1 1 1 0 1 1 1 0 Zinc-finger zf-HIT PF04438.16 KOO23554.1 - 4.8 7.2 8.3 5.1 7.1 1.3 3.0 3 0 0 3 3 3 0 HIT zinc finger PHD PF00628.29 KOO23554.1 - 8.4 6.4 15.3 1.6 8.7 11.0 2.1 2 1 0 2 2 2 0 PHD-finger DUF4605 PF15378.6 KOO23555.1 - 0.08 12.8 1.6 0.15 12.0 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) O-FucT PF10250.9 KOO23556.1 - 9.5e-12 45.3 0.0 1.2e-10 41.7 0.0 2.2 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase zf_CCCH_4 PF18345.1 KOO23556.1 - 3.9e-06 26.7 2.3 3.9e-06 26.7 2.3 2.7 2 1 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 KOO23556.1 - 5.4e-05 22.9 3.1 0.00015 21.5 0.7 2.7 2 0 0 2 2 2 1 CCCH-type zinc finger zf-CCCH PF00642.24 KOO23556.1 - 6.1e-05 22.8 8.5 0.00048 20.0 0.6 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KOO23556.1 - 0.00017 22.3 0.6 0.00017 22.3 0.6 1.9 1 1 1 2 2 2 1 Torus domain zf-CCCH_3 PF15663.5 KOO23556.1 - 0.042 14.1 3.3 0.096 12.9 3.3 1.5 1 0 0 1 1 1 0 Zinc-finger containing family Pkinase PF00069.25 KOO23557.1 - 1e-47 162.8 0.0 2.8e-46 158.0 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23557.1 - 2.8e-22 79.3 0.0 1.2e-11 44.4 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO23557.1 - 0.0001 21.2 0.0 0.0002 20.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO23557.1 - 0.044 13.7 0.1 0.044 13.7 0.1 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 KOO23557.1 - 0.12 12.0 0.0 0.39 10.3 0.0 1.8 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Pentapeptide_4 PF13599.6 KOO23558.1 - 1.5e-43 146.8 0.0 5e-06 26.6 0.0 11.1 4 2 7 13 13 13 10 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.18 KOO23558.1 - 4.8e-07 29.8 35.9 0.38 10.6 0.0 16.8 10 6 8 19 19 19 1 Ribosomal protein L13e Acetyltransf_11 PF13720.6 KOO23558.1 - 0.015 15.8 1.9 61 4.2 0.0 7.0 6 1 0 7 7 7 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Rv2175c_C PF18367.1 KOO23558.1 - 0.028 14.5 2.4 17 5.6 0.0 6.6 8 0 0 8 8 8 0 Rv2175c C-terminal domain of unknown function SinI PF08671.10 KOO23558.1 - 0.1 12.4 0.5 0.5 10.2 0.1 2.6 2 0 0 2 2 2 0 Anti-repressor SinI XK-related PF09815.9 KOO23558.1 - 1.9 7.4 9.6 10 5.0 9.6 2.0 1 1 0 1 1 1 0 XK-related protein Ank_2 PF12796.7 KOO23559.1 - 1.1e-23 83.6 0.4 8.9e-12 45.4 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO23559.1 - 2.3e-15 56.7 2.6 3.5e-09 37.0 0.1 2.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO23559.1 - 1.7e-09 37.7 0.6 0.00098 19.5 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KOO23559.1 - 4.7e-09 35.8 0.3 0.0062 16.9 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KOO23559.1 - 2.9e-06 27.4 0.7 0.00027 21.2 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) GATase PF00117.28 KOO23560.1 - 8.3e-38 130.1 0.0 1.4e-37 129.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 KOO23560.1 - 1.4e-16 60.9 0.0 3e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 GMP_synt_C PF00958.22 KOO23560.1 - 1.9e-10 40.6 0.0 2.1e-09 37.3 0.0 2.3 2 0 0 2 2 2 1 GMP synthase C terminal domain NAD_synthase PF02540.17 KOO23560.1 - 1.8e-06 27.3 0.0 3.2e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 KOO23560.1 - 0.00013 21.5 0.0 0.00047 19.7 0.0 1.8 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 KOO23560.1 - 0.00038 20.1 0.1 0.005 16.4 0.0 2.4 3 0 0 3 3 3 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 KOO23560.1 - 0.00049 19.0 0.1 0.00086 18.2 0.1 1.4 1 0 0 1 1 1 1 tRNA methyl transferase ATP_bind_3 PF01171.20 KOO23560.1 - 0.0031 17.3 0.1 0.014 15.2 0.1 1.9 2 0 0 2 2 2 1 PP-loop family PAPS_reduct PF01507.19 KOO23560.1 - 0.01 15.9 0.0 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family Asn_synthase PF00733.21 KOO23560.1 - 0.012 15.3 0.1 0.023 14.4 0.1 1.3 1 0 0 1 1 1 0 Asparagine synthase Arginosuc_synth PF00764.19 KOO23560.1 - 0.021 14.1 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase Myosin_head PF00063.21 KOO23561.1 - 5.5e-193 642.9 0.0 7.5e-193 642.4 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Tub PF01167.18 KOO23561.1 - 4.6e-14 52.7 0.0 2.3e-08 34.1 0.0 2.6 1 1 1 2 2 2 2 Tub family WD40 PF00400.32 KOO23561.1 - 1.5e-12 47.8 13.0 9.9e-05 23.0 0.1 7.3 7 0 0 7 7 7 3 WD domain, G-beta repeat WW PF00397.26 KOO23561.1 - 4.9e-05 23.3 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 WW domain DUF3527 PF12043.8 KOO23561.1 - 0.0019 17.8 0.0 0.0037 16.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3527) AAA_22 PF13401.6 KOO23561.1 - 0.0064 16.8 0.0 0.024 14.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO23561.1 - 0.023 15.1 0.1 0.023 15.1 0.1 3.2 2 1 0 2 2 2 0 AAA ATPase domain Hpr_kinase_C PF07475.12 KOO23561.1 - 0.18 11.4 0.1 0.74 9.3 0.1 2.0 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain PQQ_3 PF13570.6 KOO23561.1 - 0.18 12.3 1.8 22 5.7 0.0 4.4 4 0 0 4 4 4 0 PQQ-like domain Nup160 PF11715.8 KOO23561.1 - 0.2 10.2 1.7 1.4 7.4 0.0 2.4 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DUF4164 PF13747.6 KOO23562.1 - 0.0062 16.8 0.5 0.024 14.9 0.3 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4164) DUF2096 PF09869.9 KOO23562.1 - 0.03 14.4 0.1 0.03 14.4 0.1 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) ketoacyl-synt PF00109.26 KOO23563.1 - 0.0029 17.2 0.0 0.014 15.0 0.0 2.1 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain HXXSHH PF07586.11 KOO23563.1 - 0.2 11.2 1.2 0.3 10.6 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Ras PF00071.22 KOO23565.1 - 1.1e-13 51.1 0.0 2.2e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 KOO23565.1 - 3.8e-05 23.9 0.0 0.00025 21.3 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO23565.1 - 0.009 15.5 0.0 0.18 11.3 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 KOO23565.1 - 0.025 14.0 0.0 1.2 8.5 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KOO23565.1 - 0.027 14.6 0.0 0.047 13.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 KOO23565.1 - 0.029 14.6 0.0 3 8.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain GTP_EFTU PF00009.27 KOO23565.1 - 0.044 13.3 0.0 9.7 5.7 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_5 PF07728.14 KOO23565.1 - 0.09 12.8 0.0 0.27 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KOO23565.1 - 0.12 12.9 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KOO23565.1 - 0.16 11.8 0.0 1.6 8.6 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase DUF4201 PF13870.6 KOO23567.1 - 1.2e-44 152.2 26.9 1.2e-44 152.2 26.9 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4201) DUF2935 PF11155.8 KOO23567.1 - 0.24 11.7 10.2 0.28 11.5 1.2 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) DUF4498 PF14926.6 KOO23568.1 - 1.1e-69 234.5 0.0 1.3e-69 234.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4498) Bestrophin PF01062.21 KOO23569.1 - 2.9e-23 82.7 0.6 5.4e-12 45.7 0.1 2.1 2 0 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel DctQ PF04290.12 KOO23569.1 - 7.2 6.5 8.9 1.1 9.1 0.7 2.8 2 1 1 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component SBBP PF06739.11 KOO23570.1 - 1.2e-06 28.4 24.4 0.035 14.1 1.6 3.7 3 0 0 3 3 3 3 Beta-propeller repeat AAA_6 PF12774.7 KOO23572.1 - 1.3e-154 514.0 0.6 1.8e-153 510.3 0.0 2.7 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO23572.1 - 4e-125 418.0 1.5 4e-125 418.0 1.5 3.0 2 1 1 3 3 3 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 KOO23572.1 - 3.7e-112 374.5 0.2 5.9e-111 370.6 0.0 2.9 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 KOO23572.1 - 1.5e-96 322.7 0.0 3.3e-96 321.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KOO23572.1 - 1.5e-77 259.7 3.7 2.3e-77 259.0 0.5 2.5 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 KOO23572.1 - 1.9e-60 203.5 3.0 2.6e-55 186.8 0.0 4.6 3 1 1 4 4 4 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KOO23572.1 - 4.7e-46 156.6 0.0 1.3e-45 155.2 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO23572.1 - 8.8e-40 135.5 0.0 8.4e-39 132.3 0.0 2.7 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 KOO23572.1 - 3.9e-39 134.6 14.8 9.8e-39 133.3 14.8 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 KOO23572.1 - 6.1e-27 94.3 0.0 2.5e-26 92.3 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KOO23572.1 - 2.1e-15 56.7 0.0 7.4e-15 55.0 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KOO23572.1 - 4.9e-13 49.3 0.0 0.0031 17.5 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO23572.1 - 5.1e-06 27.0 0.2 1.9 8.8 0.0 5.1 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 KOO23572.1 - 0.0013 19.0 0.8 15 5.9 0.0 4.1 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 KOO23572.1 - 0.0022 18.4 1.7 0.45 10.9 0.0 4.7 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOO23572.1 - 0.0033 17.2 1.8 3.2 7.4 0.1 3.6 3 0 0 3 3 3 1 AAA domain DUF853 PF05872.12 KOO23572.1 - 0.0037 15.9 3.3 6.4 5.2 0.0 3.3 3 0 0 3 3 3 2 Bacterial protein of unknown function (DUF853) AAA_18 PF13238.6 KOO23572.1 - 0.0044 17.6 0.1 0.73 10.4 0.0 3.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KOO23572.1 - 0.0072 16.7 0.6 1.5 9.3 0.0 3.7 4 0 0 4 4 2 1 RNA helicase HrpB2 PF09487.10 KOO23572.1 - 0.62 10.5 5.5 32 5.0 0.3 3.9 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB2) AAA_24 PF13479.6 KOO23572.1 - 1.7 8.3 3.8 7.3 6.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain DUF3856 PF12968.7 KOO23572.1 - 5.4 7.1 6.9 8.3 6.5 0.8 3.0 3 0 0 3 3 3 0 Domain of Unknown Function (DUF3856) FtsK_SpoIIIE PF01580.18 KOO23572.1 - 7.2 5.9 7.9 20 4.4 0.0 4.3 4 1 2 6 6 5 0 FtsK/SpoIIIE family Resistin PF06954.11 KOO23573.1 - 0.011 16.3 6.0 0.74 10.4 0.3 2.1 1 1 1 2 2 2 0 Resistin He_PIG PF05345.12 KOO23573.1 - 6.4 7.0 8.0 32 4.8 0.3 4.0 3 2 0 3 3 3 0 Putative Ig domain Arm PF00514.23 KOO23574.1 - 9.9e-33 111.2 35.2 1.2e-05 25.2 1.5 7.5 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat U-box PF04564.15 KOO23574.1 - 2.3e-10 40.5 0.0 5.2e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 U-box domain Atx10homo_assoc PF09759.9 KOO23574.1 - 3.8e-08 33.2 0.4 0.17 11.9 0.1 4.7 4 1 1 5 5 5 2 Spinocerebellar ataxia type 10 protein domain zf-Nse PF11789.8 KOO23574.1 - 2e-05 24.3 0.0 4.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO23574.1 - 0.0021 18.2 0.0 0.014 15.6 0.0 2.2 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_UBOX PF13445.6 KOO23574.1 - 0.054 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 RING-type zinc-finger Succ_CoA_lig PF13607.6 KOO23574.1 - 0.43 10.4 35.3 1.3 8.9 0.7 6.0 2 2 3 6 6 6 0 Succinyl-CoA ligase like flavodoxin domain DUF2935 PF11155.8 KOO23575.1 - 0.12 12.7 1.6 0.18 12.1 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) YjbH PF06082.11 KOO23575.1 - 0.13 11.1 1.5 0.16 10.8 1.5 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH DUF737 PF05300.11 KOO23575.1 - 0.2 12.0 9.5 0.25 11.7 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF3584 PF12128.8 KOO23575.1 - 0.44 8.0 15.8 0.56 7.6 15.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) eIF3_subunit PF08597.10 KOO23575.1 - 0.64 9.9 10.8 0.78 9.6 10.8 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DDRGK PF09756.9 KOO23575.1 - 1.8 8.1 10.5 2.4 7.7 10.5 1.2 1 0 0 1 1 1 0 DDRGK domain PRIMA1 PF16101.5 KOO23575.1 - 5.4 7.1 12.0 12 6.0 12.0 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 5_nucleotid PF05761.14 KOO23575.1 - 5.4 5.8 4.8 6.8 5.5 4.8 1.1 1 0 0 1 1 1 0 5' nucleotidase family BRCT_2 PF16589.5 KOO23576.1 - 1.4e-07 31.8 0.0 0.013 15.9 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KOO23576.1 - 7.1e-05 23.1 0.0 0.17 12.3 0.0 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain FHA PF00498.26 KOO23576.1 - 0.0036 17.6 0.0 0.006 16.9 0.0 1.4 1 0 0 1 1 1 1 FHA domain ART PF01129.18 KOO23577.1 - 8.3e-05 22.0 0.0 0.00034 20.0 0.0 1.9 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Cep57_CLD_2 PF14197.6 KOO23577.1 - 0.00015 21.7 7.2 0.00015 21.7 7.2 2.2 2 0 0 2 2 2 1 Centrosome localisation domain of PPC89 CENP-F_leu_zip PF10473.9 KOO23577.1 - 0.009 16.0 4.1 0.018 15.1 4.1 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tup_N PF08581.10 KOO23577.1 - 0.019 15.3 0.7 0.019 15.3 0.7 2.0 2 0 0 2 2 1 0 Tup N-terminal UPF0242 PF06785.11 KOO23577.1 - 0.025 14.7 3.2 0.043 13.9 3.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4201 PF13870.6 KOO23577.1 - 0.11 12.2 5.0 0.24 11.1 5.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) ADPrib_exo_Tox PF03496.14 KOO23577.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme SHE3 PF17078.5 KOO23577.1 - 0.16 11.7 3.1 0.37 10.5 0.4 2.2 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Bap31_Bap29_C PF18035.1 KOO23577.1 - 0.2 11.7 3.3 0.78 9.8 0.1 2.5 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain TraE PF05309.11 KOO23577.1 - 0.21 11.0 0.0 0.41 10.0 0.0 1.4 1 0 0 1 1 1 0 TraE protein HAP1_N PF04849.13 KOO23577.1 - 0.23 10.6 6.1 0.38 9.9 6.1 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region ADIP PF11559.8 KOO23577.1 - 0.25 11.4 4.7 0.51 10.4 4.7 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 KOO23577.1 - 0.35 11.4 6.2 0.95 10.0 6.2 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region Fez1 PF06818.15 KOO23577.1 - 0.35 11.3 4.0 0.11 12.9 0.9 1.7 2 0 0 2 2 2 0 Fez1 ATG16 PF08614.11 KOO23577.1 - 3.4 7.8 13.0 0.86 9.8 9.4 1.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CEP63 PF17045.5 KOO23577.1 - 7.6 6.4 9.3 1.1 9.1 4.9 1.7 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa 2OG-FeII_Oxy_3 PF13640.6 KOO23578.1 - 0.00012 22.9 0.0 0.00016 22.5 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GFO_IDH_MocA PF01408.22 KOO23579.1 - 3.7e-16 60.0 0.1 1.3e-15 58.3 0.1 1.9 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 KOO23579.1 - 0.12 12.8 0.1 0.28 11.6 0.1 1.6 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain IDO PF01231.18 KOO23580.1 - 2.7e-46 158.3 0.0 3.8e-46 157.8 0.0 1.2 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase MNR PF15718.5 KOO23580.1 - 0.086 11.0 0.1 0.13 10.4 0.1 1.1 1 0 0 1 1 1 0 Protein moonraker POTRA PF07244.15 KOO23580.1 - 0.19 12.3 0.1 0.37 11.4 0.1 1.4 1 0 0 1 1 1 0 Surface antigen variable number repeat Nucleotid_trans PF03407.16 KOO23581.1 - 1.4e-06 28.5 0.0 7.5e-06 26.1 0.0 1.9 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Rootletin PF15035.6 KOO23582.1 - 0.039 14.0 0.1 0.039 14.0 0.1 3.8 2 1 1 3 3 3 0 Ciliary rootlet component, centrosome cohesion FlgO PF17680.1 KOO23582.1 - 2.2 8.0 6.5 0.77 9.5 2.5 2.3 2 1 0 2 2 2 0 FlgO protein Amidase PF01425.21 KOO23583.1 - 1.1e-67 229.0 0.0 2.2e-67 228.0 0.0 1.5 1 1 0 1 1 1 1 Amidase Metallophos PF00149.28 KOO23584.1 - 2.7e-14 54.1 0.1 3.6e-14 53.7 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO23584.1 - 0.003 17.8 0.0 0.016 15.4 0.0 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain HECT PF00632.25 KOO23585.1 - 7.4e-76 255.6 0.0 1e-75 255.1 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DnaJ PF00226.31 KOO23586.1 - 1.6e-27 95.4 4.4 2.7e-27 94.6 4.4 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 KOO23586.1 - 3.5e-10 40.1 0.0 5.9e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain RPT PF13446.6 KOO23586.1 - 0.054 13.4 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 A repeated domain in UCH-protein VPS13 PF16908.5 KOO23588.1 - 7.1e-26 91.4 0.0 2.3e-24 86.5 0.0 2.7 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal Ank_2 PF12796.7 KOO23588.1 - 2.4e-16 60.1 0.4 1.2e-08 35.4 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO23588.1 - 2.5e-13 49.9 1.7 0.00089 19.5 0.0 5.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO23588.1 - 9.9e-12 44.8 11.4 0.00084 19.7 0.0 5.8 6 0 0 6 6 6 3 Ankyrin repeat Chorein_N PF12624.7 KOO23588.1 - 6.5e-10 39.2 0.0 1.6e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 Ank_4 PF13637.6 KOO23588.1 - 1e-09 38.7 0.5 2.9e-06 27.7 0.1 4.1 2 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO23588.1 - 2.7e-09 36.5 4.1 0.012 16.1 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeat V_ATPase_I PF01496.19 KOO23588.1 - 0.79 7.6 1.3 3.9 5.3 1.6 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family TolA_bind_tri PF16331.5 KOO23588.1 - 6.9 6.8 9.8 38 4.5 0.1 2.8 2 0 0 2 2 2 0 TolA binding protein trimerisation TetR_C_11 PF16859.5 KOO23589.1 - 0.024 14.9 2.6 0.037 14.3 2.6 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain STI1 PF17830.1 KOO23589.1 - 0.025 14.5 18.3 66 3.5 18.3 2.8 1 1 0 1 1 1 0 STI1 domain GerD PF17898.1 KOO23589.1 - 0.043 13.8 14.6 0.043 13.8 11.5 2.2 2 1 0 2 2 2 0 Spore germination GerD central core domain Cytochrome_P460 PF16694.5 KOO23589.1 - 0.11 12.9 0.6 0.18 12.1 0.6 1.3 1 0 0 1 1 1 0 Cytochrome P460 Peptidase_C97 PF05903.14 KOO23591.1 - 1.4e-10 41.2 0.0 1.8e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF4105 PF13387.6 KOO23591.1 - 0.01 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) NPL PF17800.1 KOO23592.1 - 1.1e-09 38.7 0.0 1.5e-09 38.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoplasmin-like domain Myb_DNA-binding PF00249.31 KOO23592.1 - 7.9e-08 32.4 0.1 1.5e-07 31.5 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO23592.1 - 0.08 13.2 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Myb-like DNA-binding domain DnaJ PF00226.31 KOO23593.1 - 3.5e-12 46.3 0.1 3.5e-12 46.3 0.1 2.1 2 0 0 2 2 2 1 DnaJ domain DUF5082 PF16888.5 KOO23593.1 - 0.45 10.8 4.3 0.82 10.0 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Peptidase_M49 PF03571.15 KOO23594.1 - 9.9e-203 674.5 0.0 1.2e-201 670.9 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M49 Methyltransf_11 PF08241.12 KOO23595.1 - 5.9e-11 42.9 0.0 1.2e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO23595.1 - 1.9e-06 28.4 0.0 5.3e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO23595.1 - 8.1e-06 25.7 0.0 1.1e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO23595.1 - 4.6e-05 22.9 0.0 6.4e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 KOO23595.1 - 0.0028 18.4 0.0 0.005 17.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO23595.1 - 0.025 14.4 0.0 0.036 13.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 KOO23595.1 - 0.028 14.3 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase SHR-BD PF06650.12 KOO23596.1 - 5.5e-07 29.2 0.0 4.4e-06 26.3 0.0 2.0 1 1 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 PikAIV_N PF18605.1 KOO23596.1 - 0.041 13.5 0.0 0.073 12.7 0.0 1.4 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Ank_2 PF12796.7 KOO23597.1 - 2e-26 92.3 1.5 1.1e-09 38.7 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO23597.1 - 4.1e-23 81.2 0.8 7.8e-07 29.2 0.0 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO23597.1 - 3.6e-19 68.9 2.5 0.00011 22.7 0.2 5.0 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO23597.1 - 1.7e-18 64.8 2.4 0.0019 18.5 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 KOO23597.1 - 1.7e-16 59.8 10.5 0.00043 20.6 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat VPS13_C PF16909.5 KOO23597.1 - 0.00038 20.3 0.0 0.00082 19.2 0.0 1.6 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal DUF413 PF04219.12 KOO23597.1 - 0.19 11.8 0.0 0.68 10.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF ABC1 PF03109.16 KOO23598.1 - 1.4e-26 93.0 0.0 2.3e-26 92.3 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase_Tyr PF07714.17 KOO23598.1 - 0.069 12.4 0.0 1.6 8.0 0.0 2.1 1 1 0 1 1 1 0 Protein tyrosine kinase UQ_con PF00179.26 KOO23599.1 - 8.5e-38 129.2 0.0 1e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KOO23599.1 - 0.019 14.8 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 KOO23599.1 - 0.079 13.2 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 RWD domain DUF3287 PF11690.8 KOO23601.1 - 0.003 17.3 0.9 0.65 9.7 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3287) Paralemmin PF03285.15 KOO23601.1 - 0.009 15.6 0.4 0.009 15.6 0.4 1.5 2 0 0 2 2 2 1 Paralemmin DivIC PF04977.15 KOO23601.1 - 0.011 15.4 5.2 0.02 14.6 0.9 2.4 2 0 0 2 2 2 0 Septum formation initiator APG6_N PF17675.1 KOO23601.1 - 0.017 15.7 10.1 0.048 14.2 10.1 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region ZapB PF06005.12 KOO23601.1 - 0.019 15.4 2.0 0.019 15.4 2.0 1.9 2 1 0 2 2 2 0 Cell division protein ZapB Lzipper-MIP1 PF14389.6 KOO23601.1 - 0.019 15.2 0.6 0.54 10.6 0.4 2.2 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 CREPT PF16566.5 KOO23601.1 - 0.046 13.9 2.6 0.051 13.8 1.8 1.4 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour TMF_TATA_bd PF12325.8 KOO23601.1 - 0.05 13.8 1.7 0.05 13.8 1.7 2.0 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding CLZ PF16526.5 KOO23601.1 - 0.051 13.9 5.2 0.99 9.8 1.2 2.3 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF5082 PF16888.5 KOO23601.1 - 0.057 13.7 1.9 0.057 13.7 1.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) V_ATPase_I PF01496.19 KOO23601.1 - 0.078 10.9 1.2 0.1 10.5 1.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ABC_tran_CTD PF16326.5 KOO23601.1 - 0.17 12.1 5.7 0.18 12.1 1.7 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain NBP1 PF08537.10 KOO23601.1 - 0.19 11.1 0.8 0.2 11.0 0.8 1.1 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 GAS PF13851.6 KOO23601.1 - 0.37 10.1 7.8 0.098 12.0 3.3 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding HAUS5 PF14817.6 KOO23601.1 - 0.44 9.2 7.5 0.48 9.1 7.5 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 DUF2968 PF11180.8 KOO23601.1 - 0.5 10.0 11.9 0.44 10.2 10.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) Prefoldin_2 PF01920.20 KOO23601.1 - 0.57 10.2 6.6 1.2 9.1 2.4 2.2 2 0 0 2 2 2 0 Prefoldin subunit Ax_dynein_light PF10211.9 KOO23601.1 - 0.84 9.5 6.3 0.71 9.8 4.3 1.7 1 1 1 2 2 2 0 Axonemal dynein light chain FlxA PF14282.6 KOO23601.1 - 1.4 9.0 12.2 0.57 10.2 4.7 2.3 1 1 1 2 2 2 0 FlxA-like protein U-box PF04564.15 KOO23602.1 - 8.4e-17 61.1 0.0 1.2e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO23602.1 - 0.0022 17.8 0.0 0.0036 17.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO23602.1 - 0.01 15.9 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Ank_2 PF12796.7 KOO23603.1 - 2.2e-94 310.1 46.6 2.4e-16 60.1 0.7 7.3 1 1 8 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO23603.1 - 7.3e-51 169.9 19.5 3.8e-08 33.7 0.2 9.9 8 2 2 10 10 10 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO23603.1 - 2.4e-44 148.8 29.5 8.8e-07 29.1 0.4 11.5 2 2 9 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO23603.1 - 1.7e-39 129.3 23.5 0.023 15.2 0.0 12.7 12 0 0 12 12 12 12 Ankyrin repeat Ank PF00023.30 KOO23603.1 - 2.3e-38 129.0 51.3 0.0027 18.1 0.3 12.6 12 0 0 12 12 12 12 Ankyrin repeat Pkinase PF00069.25 KOO23603.1 - 1.7e-28 99.8 0.0 3.4e-28 98.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23603.1 - 4.9e-23 81.7 0.0 8.8e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SR1P PF13790.6 KOO23603.1 - 5.2e-05 23.3 6.0 0.58 10.3 0.0 6.4 7 0 0 7 7 7 1 SR1 protein PTN_MK_N PF05196.13 KOO23603.1 - 1.1 9.5 9.1 55 4.1 0.0 5.4 6 0 0 6 6 5 0 PTN/MK heparin-binding protein family, N-terminal domain Draxin PF15550.6 KOO23603.1 - 2.9 7.7 5.6 4.6 7.0 5.6 1.2 1 0 0 1 1 1 0 Draxin Prok-RING_1 PF14446.6 KOO23603.1 - 4.9 7.2 9.9 10 6.1 0.0 5.5 7 0 0 7 7 7 0 Prokaryotic RING finger family 1 TP_methylase PF00590.20 KOO23604.1 - 6.7e-22 78.5 0.2 1e-21 77.8 0.2 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Na_sulph_symp PF00939.19 KOO23605.1 - 9e-25 87.6 22.6 1.5e-24 86.9 22.6 1.7 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KOO23605.1 - 2.7e-22 79.4 23.2 2.7e-22 79.4 23.2 1.7 1 1 0 1 1 1 1 Citrate transporter SPX PF03105.19 KOO23605.1 - 5e-08 33.3 0.0 0.0041 17.1 0.0 2.1 2 0 0 2 2 2 2 SPX domain UvrC_HhH_N PF08459.11 KOO23606.1 - 4.9e-26 91.5 0.0 4.8e-24 85.0 0.0 2.4 2 0 0 2 2 2 1 UvrC Helix-hairpin-helix N-terminal HHH_5 PF14520.6 KOO23606.1 - 4.1e-09 36.9 0.0 1.2e-08 35.4 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain ResIII PF04851.15 KOO23606.1 - 2.6e-08 34.1 0.0 5.7e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HHH_2 PF12826.7 KOO23606.1 - 6.9e-06 26.1 0.1 3.1e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif AAA_30 PF13604.6 KOO23606.1 - 0.00012 21.8 0.2 0.00066 19.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 KOO23606.1 - 0.0011 18.8 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase FIST PF08495.10 KOO23606.1 - 0.013 15.5 0.4 0.06 13.4 0.4 2.2 1 0 0 1 1 1 0 FIST N domain HHH_3 PF12836.7 KOO23606.1 - 0.071 13.4 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif DAP3 PF10236.9 KOO23606.1 - 0.11 11.7 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RPN6_N PF18055.1 KOO23607.1 - 2.1e-31 108.7 4.7 2.5e-31 108.4 2.0 2.3 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 KOO23607.1 - 2.9e-16 59.9 0.9 5.4e-15 55.8 0.1 3.0 3 0 0 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 KOO23607.1 - 8.1e-11 41.5 1.2 8.1e-11 41.5 1.2 2.2 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 KOO23607.1 - 1.1e-06 28.8 2.9 0.046 14.0 1.5 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat RPN7 PF10602.9 KOO23607.1 - 0.004 16.9 0.7 0.018 14.8 0.1 2.3 2 1 0 2 2 2 1 26S proteasome subunit RPN7 MIT PF04212.18 KOO23607.1 - 0.013 15.6 2.9 0.48 10.5 0.0 3.7 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.28 KOO23607.1 - 0.33 10.9 3.4 3.2 7.7 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23607.1 - 0.85 9.9 3.9 38 4.7 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23607.1 - 1.5 9.4 7.9 0.95 10.0 0.8 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 KOO23607.1 - 1.7 9.0 9.5 9.4 6.6 2.3 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 KOO23607.1 - 5.2 6.7 8.3 0.59 9.8 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain DUF3493 PF11998.8 KOO23609.1 - 9.5e-12 44.9 0.9 1.7e-11 44.1 0.9 1.5 1 0 0 1 1 1 1 Low psii accumulation1 / Rep27 PseudoU_synth_2 PF00849.22 KOO23610.1 - 2.5e-08 34.2 0.0 3.3e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Prenylcys_lyase PF07156.14 KOO23611.1 - 1.6e-37 129.5 0.0 2.5e-36 125.6 0.0 2.3 1 1 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 KOO23611.1 - 2.4e-09 37.0 0.4 0.00034 20.0 0.3 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO23611.1 - 1.2e-07 31.8 0.3 3.2e-07 30.5 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOO23611.1 - 0.009 16.0 0.8 1.2 9.1 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 KOO23611.1 - 0.3 10.3 1.1 1.3 8.2 0.9 1.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SHOCT PF09851.9 KOO23612.1 - 0.00039 20.1 0.1 0.00078 19.1 0.1 1.6 1 0 0 1 1 1 1 Short C-terminal domain DMAP_binding PF06464.11 KOO23612.1 - 0.02 15.7 0.0 0.04 14.7 0.0 1.4 1 0 0 1 1 1 0 DMAP1-binding Domain Lsm_interact PF05391.11 KOO23612.1 - 0.23 11.0 1.0 0.63 9.6 1.0 1.7 1 0 0 1 1 1 0 Lsm interaction motif TPR_12 PF13424.6 KOO23613.1 - 0.00046 20.4 1.7 0.00046 20.4 1.7 3.9 2 2 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23613.1 - 0.023 14.9 3.8 0.72 10.2 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Aminotran_5 PF00266.19 KOO23614.1 - 6.5e-92 308.3 0.0 7.6e-92 308.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KOO23614.1 - 2.9e-06 26.8 0.0 4.2e-06 26.2 0.0 1.3 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KOO23614.1 - 0.00051 19.5 0.1 0.00081 18.8 0.1 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 KOO23614.1 - 0.056 12.0 0.0 0.086 11.3 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.19 KOO23614.1 - 0.073 11.8 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Mrr_cat PF04471.12 KOO23614.1 - 0.17 11.9 0.0 0.62 10.1 0.0 1.9 2 0 0 2 2 2 0 Restriction endonuclease PTCB-BRCT PF12738.7 KOO23615.1 - 8e-09 35.3 0.0 3.6e-08 33.2 0.0 2.0 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.26 KOO23615.1 - 1e-08 35.4 0.0 1.6e-06 28.4 0.0 2.9 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KOO23615.1 - 7e-05 23.2 0.0 0.011 16.1 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 KOO23615.1 - 0.018 14.9 0.0 5.7 6.9 0.0 2.5 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain Ank_2 PF12796.7 KOO23616.1 - 2.1e-18 66.7 0.1 4e-11 43.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO23616.1 - 8e-16 57.9 1.0 1.3e-05 25.4 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO23616.1 - 4e-14 51.3 0.3 0.00027 21.2 0.3 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO23616.1 - 3.1e-13 49.5 0.4 4.2e-05 23.8 1.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KOO23616.1 - 1.2e-12 48.1 2.0 8.1e-06 26.3 1.4 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) DUF4554 PF15091.6 KOO23616.1 - 1 8.2 6.2 2.2 7.1 6.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) EF-hand_6 PF13405.6 KOO23617.1 - 5.1e-21 72.8 1.1 0.00013 21.6 0.1 6.7 7 0 0 7 7 7 4 EF-hand domain EF-hand_1 PF00036.32 KOO23617.1 - 1.2e-19 68.3 6.3 0.00027 20.3 0.1 5.9 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.6 KOO23617.1 - 1.8e-17 63.6 1.4 2.7e-05 24.5 0.0 4.9 2 1 1 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO23617.1 - 2.7e-16 59.1 0.2 0.00015 21.5 0.1 5.5 6 0 0 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO23617.1 - 9.6e-11 40.7 7.7 4.5e-05 22.7 0.1 5.0 5 0 0 5 5 5 3 EF hand CheX PF13690.6 KOO23617.1 - 0.0074 16.4 0.0 0.034 14.3 0.0 2.0 2 0 0 2 2 2 1 Chemotaxis phosphatase CheX Cellulase PF00150.18 KOO23619.1 - 3e-10 40.0 0.0 9.4e-10 38.4 0.0 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CDC37_N PF03234.14 KOO23619.1 - 0.031 15.2 1.0 0.09 13.7 0.2 2.1 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding DUF4998 PF16389.5 KOO23619.1 - 0.16 11.5 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function SMC_hinge PF06470.13 KOO23619.1 - 0.18 12.1 0.0 14 6.0 0.0 2.8 2 1 0 2 2 2 0 SMC proteins Flexible Hinge Domain DUF1190 PF06693.11 KOO23621.1 - 1.9 8.9 7.3 0.83 10.0 0.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1190) DUF4988 PF16378.5 KOO23622.1 - 0.24 11.1 4.8 0.38 10.4 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF2075 PF09848.9 KOO23622.1 - 0.86 8.8 11.8 1.2 8.3 11.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) GAS PF13851.6 KOO23622.1 - 3 7.1 41.3 0.031 13.6 10.3 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Ion_trans_2 PF07885.16 KOO23623.1 - 1.5e-16 60.1 1.0 2.3e-16 59.5 1.0 1.2 1 0 0 1 1 1 1 Ion channel EF-hand_1 PF00036.32 KOO23623.1 - 0.00023 20.5 0.2 0.06 12.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO23623.1 - 0.00082 19.1 0.1 0.027 14.4 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO23623.1 - 0.0014 19.1 0.0 0.18 12.2 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO23623.1 - 0.0027 17.1 2.9 0.043 13.3 0.3 2.6 3 0 0 3 3 3 1 EF hand Ion_trans PF00520.31 KOO23623.1 - 0.073 12.3 0.0 0.095 11.9 0.0 1.1 1 0 0 1 1 1 0 Ion transport protein VCBS PF13517.6 KOO23624.1 - 1.4e-111 365.1 127.9 1.4e-13 51.2 4.1 13.2 4 3 9 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO23624.1 - 1.5e-53 178.5 136.6 3.9e-05 23.7 2.0 13.8 13 1 0 13 13 13 13 FG-GAP repeat TM_PBP2_N PF16296.5 KOO23624.1 - 1.4e-08 34.7 0.0 14 5.9 0.0 8.5 10 0 0 10 10 10 1 N-terminal of TM subunit in PBP-dependent ABC transporters Dockerin_1 PF00404.18 KOO23624.1 - 6.3e-07 29.5 38.5 14 6.0 0.1 12.7 13 0 0 13 13 13 1 Dockerin type I domain HET-s_218-289 PF11558.8 KOO23624.1 - 1.2e-05 25.2 0.0 27 4.9 0.0 8.9 13 0 0 13 13 13 0 Het-s 218-289 TcdB_toxin_midN PF12256.8 KOO23624.1 - 4.9e-05 22.8 55.5 3.6 6.9 0.2 12.0 6 4 6 12 12 12 7 Insecticide toxin TcdB middle/N-terminal region T4BSS_DotH_IcmK PF12293.8 KOO23624.1 - 7.5e-05 22.1 0.0 6.5 5.9 0.0 5.6 4 2 0 5 5 5 1 Putative outer membrane core complex of type IVb secretion BBS1 PF14779.6 KOO23624.1 - 0.0096 15.4 13.5 38 3.6 0.0 9.0 11 2 2 13 13 13 0 Ciliary BBSome complex subunit 1 Arrestin_N PF00339.29 KOO23624.1 - 0.016 15.3 1.0 23 5.1 0.0 5.9 9 0 0 9 9 9 0 Arrestin (or S-antigen), N-terminal domain YchF-GTPase_C PF06071.13 KOO23625.1 - 3.1e-38 129.8 0.3 6.9e-38 128.7 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 KOO23625.1 - 1.6e-18 66.9 0.0 5.9e-18 65.0 0.0 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOO23625.1 - 7.3e-06 25.6 0.0 1.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B LexA_DNA_bind PF01726.16 KOO23626.1 - 0.13 12.0 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 LexA DNA binding domain Aldedh PF00171.22 KOO23627.1 - 4.6e-136 454.0 0.2 1.4e-135 452.4 0.7 1.5 2 0 0 2 2 2 1 Aldehyde dehydrogenase family Amidohydro_2 PF04909.14 KOO23627.1 - 3.3e-38 132.1 5.8 3.3e-38 132.1 5.8 2.3 3 0 0 3 3 3 1 Amidohydrolase Ribonuc_L-PSP PF01042.21 KOO23627.1 - 1.4e-22 80.0 0.0 6e-22 77.9 0.0 2.2 2 0 0 2 2 2 1 Endoribonuclease L-PSP ABC_membrane PF00664.23 KOO23629.1 - 2.1e-20 73.5 2.3 2.8e-20 73.1 2.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOO23629.1 - 7e-19 68.7 0.0 1.6e-18 67.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 KOO23629.1 - 0.0042 17.5 0.0 0.012 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 KOO23629.1 - 0.0048 17.4 0.0 0.0099 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KOO23629.1 - 0.016 15.1 0.0 0.045 13.6 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 KOO23629.1 - 0.025 14.3 0.0 0.07 12.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 KOO23629.1 - 0.049 13.6 0.1 0.14 12.1 0.1 1.6 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_25 PF13481.6 KOO23629.1 - 0.05 13.2 0.2 0.15 11.6 0.2 1.8 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 KOO23629.1 - 0.053 13.0 0.1 0.42 10.0 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Adeno_IVa2 PF02456.15 KOO23629.1 - 0.054 12.3 0.0 0.083 11.7 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_22 PF13401.6 KOO23629.1 - 0.1 12.9 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Tsi6 PF18660.1 KOO23629.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Tsi6 ABC_membrane PF00664.23 KOO23630.1 - 6.1e-30 104.8 1.4 8.5e-30 104.3 1.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOO23630.1 - 6.6e-27 94.7 0.0 1.2e-26 93.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOO23630.1 - 1e-07 31.7 0.0 1e-05 25.1 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 KOO23630.1 - 0.015 15.3 0.1 0.036 14.2 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 KOO23630.1 - 0.018 15.4 0.1 0.043 14.2 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 KOO23630.1 - 0.023 14.8 0.2 0.063 13.4 0.2 1.7 2 0 0 2 2 2 0 Helicase HerA, central domain Chlorosome_CsmC PF11098.8 KOO23630.1 - 0.08 12.9 0.8 0.2 11.6 0.1 2.1 2 0 0 2 2 2 0 Chlorosome envelope protein C IstB_IS21 PF01695.17 KOO23630.1 - 0.1 12.3 0.0 0.74 9.5 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF815 PF05673.13 KOO23630.1 - 0.11 11.7 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATP_synt_H PF05493.13 KOO23630.1 - 2.3 8.8 6.1 0.32 11.5 1.4 2.0 2 0 0 2 2 2 0 ATP synthase subunit H Peptidase_A24 PF01478.18 KOO23630.1 - 6.2 7.3 7.1 3.1 8.3 0.1 2.7 2 1 0 2 2 2 0 Type IV leader peptidase family SLATT_1 PF18181.1 KOO23630.1 - 7 6.6 5.8 4 7.4 0.5 3.0 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 Ion_trans PF00520.31 KOO23631.1 - 4.9e-155 513.9 50.9 1.4e-51 175.1 4.0 4.0 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO23631.1 - 9.1e-06 24.6 58.3 0.037 12.7 0.8 9.0 8 1 1 9 9 9 7 Polycystin cation channel DUF4834 PF16118.5 KOO23631.1 - 0.015 16.2 2.8 5.7 8.0 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) LRR_6 PF13516.6 KOO23632.1 - 3.1e-05 23.7 1.6 0.056 13.5 0.0 3.0 3 0 0 3 3 3 2 Leucine Rich repeat Dehydratase_SU PF02287.15 KOO23632.1 - 0.11 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Dehydratase small subunit cNMP_binding PF00027.29 KOO23633.1 - 5.1e-14 52.1 0.0 8.8e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Serine_protease PF18405.1 KOO23633.1 - 0.024 13.8 0.0 0.077 12.1 0.0 1.8 2 0 0 2 2 2 0 Gammaproteobacterial serine protease FKBP_C PF00254.28 KOO23634.1 - 5.3e-19 68.3 0.0 9.1e-19 67.6 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Rotamase PF00639.21 KOO23634.1 - 1.6e-15 57.8 0.0 2.8e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOO23634.1 - 8.6e-14 52.1 0.0 1.5e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain FKBP_N PF01346.18 KOO23634.1 - 0.0001 23.2 0.0 0.00024 22.0 0.0 1.6 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase FKBP_C PF00254.28 KOO23635.1 - 7.9e-17 61.4 0.0 1.4e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Rotamase_3 PF13616.6 KOO23635.1 - 2.9e-15 56.8 0.0 4.1e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 KOO23635.1 - 2.5e-14 54.0 0.0 4.7e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain FKBP_N PF01346.18 KOO23635.1 - 0.00027 21.8 0.0 0.00092 20.1 0.0 1.9 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Aldo_ket_red PF00248.21 KOO23636.1 - 7.5e-40 137.0 0.0 1.3e-34 119.7 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family Reo_P9 PF06043.11 KOO23636.1 - 0.13 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Reovirus P9-like family EF-hand_5 PF13202.6 KOO23637.1 - 3.3e-10 39.0 0.0 2.1e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO23637.1 - 5.5e-10 38.1 0.0 2.3e-06 26.8 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO23637.1 - 2e-09 37.8 0.0 3.2e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO23637.1 - 6.5e-09 35.5 0.0 7.9e-07 28.8 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23637.1 - 1.6e-08 33.8 0.0 1.6e-06 27.6 0.0 2.6 1 1 1 2 2 2 1 EF-hand domain EF-hand_9 PF14658.6 KOO23637.1 - 0.00074 19.8 0.0 0.00098 19.4 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain TPR_1 PF00515.28 KOO23638.1 - 9.9e-07 28.3 4.4 0.0032 17.2 0.0 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23638.1 - 3.9e-06 26.6 7.8 0.0095 16.0 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23638.1 - 5.8e-06 26.9 9.5 0.052 14.2 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat PDZ_6 PF17820.1 KOO23638.1 - 0.00055 19.7 0.1 0.0014 18.4 0.1 1.8 1 0 0 1 1 1 1 PDZ domain TPR_14 PF13428.6 KOO23638.1 - 0.0015 19.2 3.5 0.0055 17.4 0.0 3.8 3 1 1 4 4 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23638.1 - 0.0016 18.5 0.1 0.0075 16.4 0.0 2.3 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23638.1 - 0.0052 17.3 0.8 0.2 12.2 0.1 5.5 5 1 1 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO23638.1 - 0.0071 16.5 3.0 0.016 15.4 0.1 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 PDZ_2 PF13180.6 KOO23638.1 - 0.0082 16.4 0.0 0.039 14.3 0.0 2.0 1 1 1 2 2 2 1 PDZ domain TPR_11 PF13414.6 KOO23638.1 - 0.021 14.5 6.7 0.089 12.5 0.5 3.6 3 1 1 4 4 4 0 TPR repeat TPR_12 PF13424.6 KOO23638.1 - 0.08 13.2 0.1 0.08 13.2 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO23638.1 - 0.48 11.2 2.8 25 5.8 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Glyco_transf_25 PF01755.17 KOO23639.1 - 1.4e-05 25.1 0.0 2.1e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) EF-hand_6 PF13405.6 KOO23640.1 - 2.2e-37 123.8 0.1 5.3e-05 22.8 0.0 6.5 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.32 KOO23640.1 - 2.6e-36 120.5 0.5 3.1e-06 26.3 0.4 6.4 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.6 KOO23640.1 - 4.6e-33 111.3 5.9 1.8e-05 24.0 0.0 6.5 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO23640.1 - 3.3e-30 104.3 0.4 1.1e-09 38.5 0.1 4.7 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO23640.1 - 3e-21 75.0 3.7 3.9e-08 33.0 0.2 6.0 5 1 1 6 6 6 4 EF-hand domain pair WW PF00397.26 KOO23640.1 - 0.00062 19.8 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 WW domain EF-hand_11 PF08976.11 KOO23640.1 - 0.011 16.5 0.0 0.12 13.3 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain EF-hand_4 PF12763.7 KOO23640.1 - 0.067 13.1 1.8 6.3 6.8 0.2 3.4 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand IQ PF00612.27 KOO23640.1 - 0.069 13.0 0.2 0.22 11.4 0.2 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif HrpJ PF07201.11 KOO23640.1 - 1.2 9.5 3.8 31 4.8 0.0 3.0 3 0 0 3 3 3 0 HrpJ-like domain 3HCDH_N PF02737.18 KOO23641.1 - 7.9e-07 29.1 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SQHop_cyclase_N PF13249.6 KOO23643.1 - 0.064 12.3 0.4 0.12 11.5 0.4 1.3 1 0 0 1 1 1 0 Squalene-hopene cyclase N-terminal domain FlgN PF05130.12 KOO23643.1 - 0.092 13.3 1.8 9 6.8 0.1 3.1 2 1 1 3 3 3 0 FlgN protein EF-hand_7 PF13499.6 KOO23645.1 - 1.5e-11 44.6 1.1 2.5e-10 40.7 0.4 3.1 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO23645.1 - 4e-11 41.6 1.3 7.1e-06 25.2 0.8 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO23645.1 - 8.3e-08 31.4 0.6 0.011 15.3 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO23645.1 - 1.7e-07 30.9 1.0 1.1e-06 28.4 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23645.1 - 2.6e-07 30.0 0.1 0.017 15.0 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO23645.1 - 0.024 14.6 0.1 0.063 13.2 0.1 1.7 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO23645.1 - 0.034 14.5 0.1 0.13 12.6 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain TFIIA PF03153.13 KOO23645.1 - 0.042 13.8 9.2 0.064 13.2 9.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SPARC_Ca_bdg PF10591.9 KOO23645.1 - 0.12 12.7 0.0 0.12 12.7 0.0 2.5 2 1 0 2 2 1 0 Secreted protein acidic and rich in cysteine Ca binding region Borrelia_P83 PF05262.11 KOO23645.1 - 0.18 10.3 24.0 0.34 9.3 24.0 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein Presenilin PF01080.17 KOO23645.1 - 0.76 8.5 7.7 1.2 7.9 7.7 1.2 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 KOO23645.1 - 3 5.6 9.1 4.3 5.1 9.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S64 PF08192.11 KOO23645.1 - 3.6 6.0 7.0 5.6 5.3 7.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF72 PF01904.18 KOO23646.1 - 3.1e-31 109.2 0.1 3.6e-31 109.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF72 U-box PF04564.15 KOO23647.1 - 5.8e-11 42.4 0.0 1.2e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO23647.1 - 0.00025 20.8 0.0 0.00046 20.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Ank PF00023.30 KOO23647.1 - 0.0014 18.9 0.2 0.0042 17.5 0.2 1.8 1 0 0 1 1 1 1 Ankyrin repeat zf-NOSIP PF15906.5 KOO23647.1 - 0.0034 17.5 0.0 0.0062 16.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Ank_2 PF12796.7 KOO23647.1 - 0.0051 17.4 0.3 0.011 16.4 0.3 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) DUF4037 PF13228.6 KOO23647.1 - 0.022 15.5 0.2 0.045 14.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4037) Ank_5 PF13857.6 KOO23647.1 - 0.05 13.9 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Porin_5 PF16930.5 KOO23647.1 - 1.4 7.4 4.6 2 6.8 4.6 1.2 1 0 0 1 1 1 0 Putative porin Hint PF01079.20 KOO23648.1 - 2.6e-15 56.5 0.1 4.2e-15 55.8 0.1 1.3 1 1 0 1 1 1 1 Hint module Thioesterase PF00975.20 KOO23648.1 - 0.0058 16.8 0.0 0.0071 16.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Intein_splicing PF14890.6 KOO23648.1 - 0.069 13.1 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 Intein splicing domain LRR_6 PF13516.6 KOO23649.1 - 0.00015 21.6 0.0 0.53 10.5 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich repeat FTZ PF03867.14 KOO23649.1 - 0.029 13.9 1.4 0.043 13.4 1.4 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region LRR_4 PF12799.7 KOO23649.1 - 0.2 12.1 0.0 1.2 9.7 0.0 2.3 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) E1-E2_ATPase PF00122.20 KOO23650.1 - 2.6e-45 154.2 0.9 2.6e-45 154.2 0.9 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KOO23650.1 - 4.3e-30 105.6 6.5 3.5e-29 102.6 5.4 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 KOO23650.1 - 2.7e-15 56.5 0.0 5.9e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 Heavy-metal-associated domain HAD PF12710.7 KOO23650.1 - 1.6e-06 28.7 0.0 2.8e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOO23650.1 - 0.0004 20.2 0.2 0.0012 18.7 0.3 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase EccE PF11203.8 KOO23650.1 - 0.66 10.3 3.5 2 8.8 0.4 2.8 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE DUF2749 PF10907.8 KOO23651.1 - 0.098 12.8 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) EF-hand_6 PF13405.6 KOO23652.1 - 1.3e-10 40.3 0.7 3.2e-05 23.5 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO23652.1 - 3.9e-10 38.5 0.5 2.3e-05 23.6 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO23652.1 - 6.3e-09 36.2 1.5 6.5e-07 29.7 0.3 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO23652.1 - 4.5e-06 26.4 0.5 6.9e-05 22.6 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO23652.1 - 2.3e-05 23.7 1.8 0.00021 20.6 0.4 2.6 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 KOO23652.1 - 0.049 14.0 0.9 0.56 10.6 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain Occludin_ELL PF07303.13 KOO23652.1 - 0.8 10.5 6.6 2 9.2 2.4 3.0 2 0 0 2 2 2 0 Occludin homology domain Podoplanin PF05808.11 KOO23652.1 - 2.5 8.2 10.2 0.12 12.5 0.8 2.8 1 1 2 3 3 3 0 Podoplanin YbjQ_1 PF01906.17 KOO23653.1 - 8.8e-13 48.8 0.2 1.4e-12 48.2 0.2 1.3 1 0 0 1 1 1 1 Putative heavy-metal-binding LRR_6 PF13516.6 KOO23655.1 - 1.4e-11 43.5 0.0 0.00019 21.2 0.0 3.5 3 0 0 3 3 3 3 Leucine Rich repeat LRR_4 PF12799.7 KOO23655.1 - 0.0034 17.7 0.0 1.2 9.7 0.0 2.8 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO23655.1 - 0.008 15.9 0.0 18 5.2 0.0 3.9 4 0 0 4 4 4 1 Leucine rich repeat HTH_31 PF13560.6 KOO23655.1 - 0.041 14.2 3.2 18 5.8 0.2 4.9 4 1 1 5 5 5 0 Helix-turn-helix domain NMT PF01233.19 KOO23656.1 - 9.3e-25 87.3 0.0 1.4e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 KOO23656.1 - 1.2e-05 25.3 0.0 0.00014 22.0 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO23656.1 - 0.00033 20.6 0.0 0.00065 19.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NMT_C PF02799.15 KOO23656.1 - 0.0047 16.5 0.0 0.0075 15.8 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_1 PF00583.25 KOO23656.1 - 0.0087 16.3 0.0 0.038 14.2 0.0 2.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO23656.1 - 0.021 15.3 0.0 0.061 13.7 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain SHIPPO-rpt PF07004.12 KOO23657.1 - 2.3e-06 28.2 33.8 0.00019 22.2 0.5 7.0 8 1 0 8 8 8 4 Sperm-tail PG-rich repeat TPR_1 PF00515.28 KOO23659.1 - 4.3e-57 187.7 34.0 9e-06 25.3 0.0 12.5 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23659.1 - 1.4e-49 162.2 35.0 7.6e-05 22.5 0.1 12.6 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23659.1 - 1.3e-27 93.7 31.6 0.00082 19.4 0.0 12.3 12 1 0 12 12 11 8 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23659.1 - 5.3e-26 90.0 19.7 4.2e-06 26.3 0.3 10.4 4 3 6 10 10 10 6 TPR repeat TPR_14 PF13428.6 KOO23659.1 - 9.9e-20 69.6 35.5 0.0012 19.5 0.0 12.8 5 4 8 13 13 13 6 Tetratricopeptide repeat TPR_17 PF13431.6 KOO23659.1 - 4.3e-18 64.3 15.6 0.00043 20.5 0.4 10.1 11 0 0 11 11 9 4 Tetratricopeptide repeat TPR_9 PF13371.6 KOO23659.1 - 8.2e-17 61.1 22.4 0.00024 21.2 1.7 7.1 4 2 2 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23659.1 - 8.1e-12 45.5 27.7 0.0044 17.5 0.9 7.5 7 1 1 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23659.1 - 4.5e-10 39.7 30.9 0.0017 18.6 0.1 8.8 8 3 2 10 10 9 4 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO23659.1 - 5.2e-10 39.2 18.7 3.1 7.9 0.0 10.5 10 2 2 12 12 11 2 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 KOO23659.1 - 8.8e-10 39.1 29.5 0.0065 17.1 0.4 7.8 4 4 4 8 8 8 5 Tetratricopeptide repeat NARP1 PF12569.8 KOO23659.1 - 1.8e-07 30.4 10.7 0.0078 15.2 0.0 4.6 1 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 KOO23659.1 - 4.8e-07 30.0 11.9 0.2 12.0 0.2 5.5 4 2 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23659.1 - 4.5e-06 26.3 14.2 1 9.5 0.0 7.8 9 0 0 9 9 8 2 Tetratricopeptide repeat NDK PF00334.19 KOO23659.1 - 0.00028 20.9 0.0 0.045 13.8 0.0 2.4 2 0 0 2 2 2 1 Nucleoside diphosphate kinase SHNi-TPR PF10516.9 KOO23659.1 - 0.00033 20.1 8.7 5.3 6.6 0.0 6.4 7 0 0 7 7 7 1 SHNi-TPR Toxin_13 PF07822.11 KOO23659.1 - 0.0034 17.5 3.8 16 5.7 0.0 4.4 4 0 0 4 4 4 0 Neurotoxin B-IV-like protein NYD-SP12_N PF15015.6 KOO23659.1 - 0.023 13.1 0.5 0.13 10.6 0.1 2.2 2 1 1 3 3 3 0 Spermatogenesis-associated, N-terminal Mad3_BUB1_I_2 PF17014.5 KOO23659.1 - 0.077 13.1 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein zf-C2H2_9 PF16293.5 KOO23659.1 - 0.12 12.2 0.0 17 5.3 0.0 3.1 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) YL1_C PF08265.11 KOO23659.1 - 0.14 12.0 3.0 42 4.0 0.1 4.1 4 0 0 4 4 4 0 YL1 nuclear protein C-terminal domain BTAD PF03704.17 KOO23659.1 - 0.23 11.9 23.6 0.55 10.7 1.4 5.0 2 2 2 5 5 5 0 Bacterial transcriptional activator domain ChAPs PF09295.10 KOO23659.1 - 0.66 8.9 8.1 6.6 5.6 0.2 3.3 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Vta1_C PF18097.1 KOO23659.1 - 0.73 9.6 4.4 35 4.2 0.3 4.4 4 0 0 4 4 4 0 Vta1 C-terminal domain TPR_10 PF13374.6 KOO23659.1 - 1.5 8.8 30.5 0.76 9.7 0.9 8.2 10 1 1 11 11 9 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO23659.1 - 3.2 8.0 14.8 4.7 7.5 0.4 5.0 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Got1 PF04178.12 KOO23661.1 - 1.3e-30 106.1 12.6 2.1e-30 105.4 12.6 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family LEA_1 PF03760.15 KOO23661.1 - 4.5 8.0 19.9 0.25 12.0 3.9 3.4 3 2 0 3 3 3 0 Late embryogenesis abundant (LEA) group 1 DUF883 PF05957.13 KOO23661.1 - 7.5 7.2 8.9 12 6.6 4.0 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Nipped-B_C PF12830.7 KOO23662.1 - 1.2e-09 38.4 0.0 0.00083 19.3 0.0 3.3 2 1 0 3 3 3 2 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 KOO23662.1 - 3.5e-08 33.6 12.0 2e-05 24.8 1.1 3.9 3 0 0 3 3 3 2 HEAT repeat associated with sister chromatid cohesion PHD PF00628.29 KOO23662.1 - 7e-08 32.2 9.8 1.9e-07 30.9 9.8 1.8 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KOO23662.1 - 9.6e-05 21.9 4.9 0.00024 20.6 4.9 1.8 1 0 0 1 1 1 1 PHD-finger TUDOR_5 PF18359.1 KOO23662.1 - 0.00018 21.2 0.1 0.00035 20.2 0.1 1.4 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 Tudor_3 PF18115.1 KOO23662.1 - 0.00049 19.9 0.4 0.0012 18.6 0.1 1.8 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain HEAT PF02985.22 KOO23662.1 - 0.027 14.7 4.1 28 5.3 0.0 5.2 4 0 0 4 4 4 0 HEAT repeat Cnd1 PF12717.7 KOO23662.1 - 0.093 12.8 0.0 0.43 10.6 0.0 2.0 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 KOO23662.1 - 0.2 11.8 1.6 0.7 10.1 0.0 2.8 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 p25-alpha PF05517.12 KOO23663.1 - 4.2e-05 23.8 0.0 6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 p25-alpha RVT_3 PF13456.6 KOO23663.1 - 0.0041 16.9 0.0 0.0057 16.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase-like EF-hand_7 PF13499.6 KOO23663.1 - 0.017 15.6 1.5 0.06 13.8 1.4 1.9 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 KOO23663.1 - 0.031 13.8 4.1 1.2 8.9 0.0 3.7 3 1 1 4 4 4 0 EF hand EF-hand_6 PF13405.6 KOO23663.1 - 2 8.6 5.3 8 6.7 0.0 3.5 3 1 0 3 3 3 0 EF-hand domain IQ PF00612.27 KOO23664.1 - 1.9e-06 27.1 1.5 0.015 15.0 0.0 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif PH PF00169.29 KOO23664.1 - 3.1e-05 24.4 0.0 8e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 PH domain AA_permease_2 PF13520.6 KOO23665.1 - 9.8e-29 100.4 26.3 1.3e-28 100.0 26.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOO23665.1 - 4.1e-08 32.3 28.2 1.6e-07 30.3 28.2 2.0 1 1 0 1 1 1 1 Amino acid permease LapA_dom PF06305.11 KOO23665.1 - 0.22 11.3 0.0 0.22 11.3 0.0 2.8 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Ufm1 PF03671.14 KOO23666.1 - 4.6e-07 29.8 0.0 9.1e-07 28.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin fold modifier 1 protein AlaDh_PNT_C PF01262.21 KOO23667.1 - 0.00019 20.8 0.1 0.00036 19.9 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 KOO23667.1 - 0.00045 19.6 0.0 0.004 16.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO23667.1 - 0.003 16.8 0.0 0.0057 15.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO23667.1 - 0.0039 16.5 6.6 0.018 14.3 0.3 3.0 2 1 1 3 3 3 1 FAD binding domain HI0933_like PF03486.14 KOO23667.1 - 0.015 14.1 0.2 0.024 13.3 0.2 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 KOO23667.1 - 0.024 15.2 0.4 0.055 14.0 0.4 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOO23667.1 - 0.031 14.5 0.0 0.087 13.1 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO23667.1 - 0.046 12.8 0.3 0.046 12.8 0.3 2.2 2 0 0 2 2 2 0 FAD binding domain XdhC_C PF13478.6 KOO23667.1 - 0.32 11.5 4.1 0.32 11.5 0.0 2.8 3 0 0 3 3 3 0 XdhC Rossmann domain PDZ PF00595.24 KOO23668.1 - 0.0061 16.9 0.0 0.01 16.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO23668.1 - 0.0069 16.7 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KOO23668.1 - 0.031 14.2 0.0 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Tricorn protease PDZ domain PDZ_6 PF17820.1 KOO23668.1 - 0.079 12.8 0.1 0.24 11.3 0.1 1.9 1 1 1 2 2 2 0 PDZ domain Roughex PF06020.11 KOO23669.1 - 5.5 6.0 6.6 7.3 5.6 6.6 1.1 1 0 0 1 1 1 0 Drosophila roughex protein TPR_12 PF13424.6 KOO23670.1 - 4e-05 23.8 1.2 0.00021 21.5 0.4 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23670.1 - 0.083 13.0 2.5 0.13 12.4 0.3 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-GRF PF06839.12 KOO23672.1 - 5.4 7.2 9.3 1.6 8.9 5.6 2.1 1 1 0 1 1 1 0 GRF zinc finger Cation_ATPase_C PF00689.21 KOO23673.1 - 5e-50 169.7 1.5 1.1e-49 168.7 1.5 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KOO23673.1 - 1.4e-48 164.8 0.5 1.4e-48 164.8 0.5 3.6 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 KOO23673.1 - 1.6e-18 66.2 3.8 2.5e-18 65.5 0.2 2.8 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 KOO23673.1 - 1.4e-17 63.5 0.0 3e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOO23673.1 - 4.1e-17 63.2 8.2 3.3e-16 60.2 5.3 3.0 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOO23673.1 - 0.00014 21.7 1.9 0.0003 20.6 1.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOO23673.1 - 0.0005 20.5 0.1 0.0023 18.4 0.0 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Methyltransf_21 PF05050.12 KOO23674.1 - 2e-06 27.9 0.0 3.7e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase FkbM domain PanZ PF12568.8 KOO23674.1 - 0.16 11.7 0.5 0.68 9.7 0.0 2.2 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain, PanZ LRR_9 PF14580.6 KOO23675.1 - 2.5e-56 189.9 0.5 4.4e-56 189.1 0.5 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KOO23675.1 - 4.7e-12 45.9 8.6 7.9e-06 26.1 5.7 3.6 2 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO23675.1 - 4.9e-09 35.8 15.6 4.4e-07 29.6 6.6 2.9 2 1 2 4 4 4 3 Leucine rich repeat PhoPQ_related PF10142.9 KOO23675.1 - 0.002 16.9 0.2 0.0033 16.2 0.2 1.2 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein LRR_6 PF13516.6 KOO23675.1 - 0.17 12.0 7.0 67 3.9 0.0 5.0 5 0 0 5 5 5 0 Leucine Rich repeat PALP PF00291.25 KOO23676.1 - 7.2e-54 183.2 2.5 7.2e-54 183.2 2.5 2.5 3 0 0 3 3 3 1 Pyridoxal-phosphate dependent enzyme Cys_Met_Meta_PP PF01053.20 KOO23676.1 - 7.1e-11 41.2 0.1 4.7e-07 28.7 0.0 2.2 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme CAP_N PF01213.19 KOO23678.1 - 2.5e-61 207.9 0.4 2.5e-61 207.9 0.4 2.5 1 1 2 3 3 3 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 KOO23678.1 - 3.8e-52 176.1 9.5 5.6e-52 175.5 9.5 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 KOO23678.1 - 7.7e-05 22.4 12.5 0.0087 15.8 3.0 2.3 1 1 1 2 2 2 2 Tubulin binding cofactor C DUF3060 PF11259.8 KOO23678.1 - 0.26 11.0 4.4 2.1 8.1 4.4 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3060) YjgF_endoribonc PF14588.6 KOO23679.1 - 2.7e-26 92.5 0.0 3.1e-26 92.3 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 KOO23679.1 - 1.1e-13 51.3 0.0 1.8e-13 50.6 0.0 1.3 1 1 0 1 1 1 1 Endoribonuclease L-PSP Ldh_2 PF02615.14 KOO23680.1 - 9.2e-79 265.0 6.0 1.1e-78 264.8 6.0 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase PucR PF07905.11 KOO23680.1 - 0.031 14.5 0.0 0.068 13.5 0.0 1.5 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family ABC_tran PF00005.27 KOO23682.1 - 5.2e-42 143.6 0.0 3.5e-20 72.9 0.0 3.1 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOO23682.1 - 9.6e-11 41.5 0.0 0.0055 16.2 0.0 3.3 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOO23682.1 - 1.4e-10 41.5 14.8 0.0024 17.8 0.2 4.3 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system Nucleotid_trans PF03407.16 KOO23682.1 - 3.1e-08 33.9 0.0 7.7e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase TPR_1 PF00515.28 KOO23682.1 - 2.2e-07 30.4 4.0 0.00088 19.0 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat ABC_tran_Xtn PF12848.7 KOO23682.1 - 6.2e-06 26.1 3.9 6.2e-06 26.1 3.9 4.0 4 0 0 4 4 2 1 ABC transporter NACHT PF05729.12 KOO23682.1 - 9e-06 25.7 0.1 0.17 11.8 0.1 2.7 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.6 KOO23682.1 - 3e-05 23.7 0.2 0.45 10.0 0.1 3.6 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 KOO23682.1 - 6.5e-05 22.6 0.3 0.014 15.1 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO23682.1 - 0.0001 22.3 0.0 0.0017 18.3 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 KOO23682.1 - 0.00055 20.5 16.9 0.089 13.3 0.0 4.4 4 1 0 4 4 3 2 AAA domain AAA PF00004.29 KOO23682.1 - 0.00069 20.0 0.1 1.7 9.1 0.1 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 KOO23682.1 - 0.0016 18.2 0.3 0.015 15.0 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain TPR_8 PF13181.6 KOO23682.1 - 0.0021 18.1 0.4 0.16 12.3 0.0 3.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23682.1 - 0.0026 17.7 10.6 0.022 14.8 0.0 4.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23682.1 - 0.0042 17.6 1.7 0.0042 17.6 1.7 3.5 3 1 0 3 3 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23682.1 - 0.0045 17.7 0.1 0.0045 17.7 0.1 5.5 5 1 1 6 6 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23682.1 - 0.0051 17.1 0.2 0.0051 17.1 0.2 3.6 3 1 0 3 3 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23682.1 - 0.0061 16.2 3.0 0.1 12.3 0.5 2.8 1 1 1 2 2 2 1 TPR repeat RNA_helicase PF00910.22 KOO23682.1 - 0.0063 16.9 0.0 0.18 12.2 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 KOO23682.1 - 0.007 16.6 0.3 2.2 8.6 0.0 3.2 2 2 0 2 2 2 1 AAA domain TPR_17 PF13431.6 KOO23682.1 - 0.011 16.0 0.2 2.9 8.5 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_24 PF13479.6 KOO23682.1 - 0.014 15.2 0.0 2.4 7.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KOO23682.1 - 0.019 15.0 1.0 0.052 13.6 0.1 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_7 PF12775.7 KOO23682.1 - 0.11 12.1 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 KOO23682.1 - 0.49 10.8 0.0 0.49 10.8 0.0 4.2 5 0 0 5 5 4 0 AAA ATPase domain AAA_33 PF13671.6 KOO23682.1 - 0.67 10.1 0.0 0.67 10.1 0.0 3.2 4 0 0 4 4 2 0 AAA domain Dynamin_N PF00350.23 KOO23682.1 - 1.5 8.8 5.0 0.3 11.1 0.1 2.4 3 0 0 3 3 1 0 Dynamin family PIN_3 PF13470.6 KOO23682.1 - 10 6.9 7.9 3.1 8.6 0.0 3.5 3 0 0 3 3 3 0 PIN domain EF-hand_1 PF00036.32 KOO23684.1 - 6.3e-35 116.1 13.5 1.1e-05 24.7 0.5 6.3 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO23684.1 - 1.8e-29 99.1 8.4 0.00026 20.7 0.0 6.7 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.6 KOO23684.1 - 7.3e-29 100.0 7.1 1.2e-09 38.5 0.2 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO23684.1 - 7.3e-23 79.0 1.8 0.00021 20.6 0.0 6.4 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO23684.1 - 3.5e-22 78.0 4.4 1.1e-07 31.5 0.1 4.5 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO23684.1 - 1.3e-12 48.1 0.8 0.015 15.6 0.0 3.2 3 0 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO23684.1 - 4.7e-11 43.5 0.6 0.015 16.2 0.1 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_10 PF14788.6 KOO23684.1 - 2.1e-06 27.5 1.9 0.47 10.3 0.0 3.4 3 0 0 3 3 3 2 EF hand PMBR PF09373.10 KOO23684.1 - 0.0012 18.9 0.0 19 5.6 0.0 4.4 4 0 0 4 4 4 0 Pseudomurein-binding repeat PP1_inhibitor PF05361.12 KOO23684.1 - 0.0057 16.7 1.3 2.4 8.1 0.2 3.4 3 1 0 3 3 3 1 PKC-activated protein phosphatase-1 inhibitor Sigma70_r1_1 PF03979.14 KOO23684.1 - 0.0078 16.2 0.3 3.7 7.7 0.1 3.6 3 1 0 3 3 3 1 Sigma-70 factor, region 1.1 EF-hand_4 PF12763.7 KOO23684.1 - 0.0094 15.9 7.2 0.75 9.8 0.2 4.3 3 3 2 5 5 5 1 Cytoskeletal-regulatory complex EF hand DUF4110 PF13422.6 KOO23684.1 - 0.018 15.1 0.1 7.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4110) DUF4760 PF15956.5 KOO23684.1 - 0.028 14.5 0.1 0.83 9.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4760) DUF1398 PF07166.11 KOO23684.1 - 0.05 13.7 0.0 22 5.1 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1398) SseB PF07179.12 KOO23684.1 - 0.07 13.4 4.2 12 6.1 0.1 3.3 3 0 0 3 3 3 0 SseB protein N-terminal domain DUF5580 PF17743.1 KOO23684.1 - 0.076 11.6 0.0 3.7 6.0 0.0 2.4 1 1 0 2 2 2 0 Family of unknown function (DUF5580) Tox-REase-3 PF15647.6 KOO23684.1 - 1.7 9.0 6.0 23 5.3 0.2 3.1 2 2 0 3 3 3 0 Restriction endonuclease fold toxin 3 GDP_Man_Dehyd PF16363.5 KOO23685.1 - 2.4e-65 221.1 0.0 2.8e-65 220.9 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOO23685.1 - 1.1e-57 195.3 0.1 1.4e-57 195.0 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KOO23685.1 - 6.8e-22 77.9 0.0 5.3e-21 75.0 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 KOO23685.1 - 1.1e-21 77.1 0.2 1.5e-21 76.7 0.2 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KOO23685.1 - 5.7e-17 61.7 0.2 3.5e-15 55.9 0.2 2.3 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 KOO23685.1 - 1.1e-16 60.8 0.0 1.6e-16 60.2 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 KOO23685.1 - 7.7e-09 35.7 0.0 1.3e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO23685.1 - 0.0029 17.2 0.0 0.0045 16.6 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Peripla_BP_6 PF13458.6 KOO23685.1 - 0.049 13.3 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein Tim17 PF02466.19 KOO23686.1 - 5.2e-11 42.9 10.4 7.5e-11 42.4 10.4 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Romo1 PF10247.9 KOO23686.1 - 4 7.9 13.6 1.3 9.4 4.1 2.7 2 1 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Rick_17kDa_Anti PF05433.15 KOO23686.1 - 8.1 6.4 17.6 0.15 12.0 2.3 3.0 3 0 0 3 3 3 0 Glycine zipper 2TM domain Cyt-b5 PF00173.28 KOO23687.1 - 8.8e-10 38.6 0.0 2e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DZR PF12773.7 KOO23687.1 - 0.11 12.6 0.1 0.23 11.5 0.1 1.5 1 0 0 1 1 1 0 Double zinc ribbon NOB1_Zn_bind PF08772.11 KOO23687.1 - 0.33 11.2 1.8 0.7 10.1 1.8 1.5 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like CS PF04969.16 KOO23688.1 - 7.5e-11 42.9 0.0 1.1e-10 42.4 0.0 1.3 1 0 0 1 1 1 1 CS domain PIH1_CS PF18201.1 KOO23688.1 - 0.034 14.5 0.0 0.51 10.8 0.0 2.2 1 1 1 2 2 2 0 PIH1 CS-like domain CTP_transf_like PF01467.26 KOO23691.1 - 0.01 16.1 0.0 0.018 15.2 0.0 1.4 1 1 0 1 1 1 0 Cytidylyltransferase-like ATP-synt_ab_N PF02874.23 KOO23691.1 - 0.08 13.5 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, beta-barrel domain S4 PF01479.25 KOO23693.1 - 1.1e-08 34.6 0.0 2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 S4 domain Nudix_N_2 PF14803.6 KOO23693.1 - 0.0007 19.5 0.3 0.0023 17.8 0.3 1.9 1 0 0 1 1 1 1 Nudix N-terminal zinc_ribbon_4 PF13717.6 KOO23693.1 - 0.01 15.7 0.0 0.029 14.3 0.0 1.8 1 0 0 1 1 1 0 zinc-ribbon domain S4_2 PF13275.6 KOO23693.1 - 0.019 14.8 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 S4 domain APG17 PF04108.12 KOO23694.1 - 1.7e-08 34.0 7.0 8.9e-07 28.4 4.7 2.4 1 1 0 2 2 2 2 Autophagy protein Apg17 Fmp27_WPPW PF10359.9 KOO23694.1 - 0.39 9.5 1.2 0.8 8.5 1.2 1.4 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Methyltr_RsmB-F PF01189.17 KOO23695.1 - 5.7e-22 78.3 0.1 1.8e-21 76.7 0.1 1.7 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F EF-hand_1 PF00036.32 KOO23695.1 - 0.00032 20.0 0.0 0.00063 19.1 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO23695.1 - 0.0016 17.9 0.1 0.0031 16.9 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO23695.1 - 0.0072 16.7 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO23695.1 - 0.0078 16.1 0.0 0.02 14.8 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain Methyltransf_25 PF13649.6 KOO23695.1 - 0.071 13.8 0.1 0.22 12.3 0.1 1.9 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_S13 PF00416.22 KOO23696.1 - 0.0047 17.3 0.4 0.35 11.3 0.1 2.4 1 1 1 2 2 2 1 Ribosomal protein S13/S18 Wbp11 PF09429.10 KOO23696.1 - 0.0056 17.1 9.9 0.92 10.0 0.9 3.1 2 1 1 3 3 3 3 WW domain binding protein 11 CsbD PF05532.12 KOO23696.1 - 0.0056 16.5 1.5 4 7.4 0.1 3.2 3 0 0 3 3 3 1 CsbD-like Caudo_TAP PF02413.17 KOO23696.1 - 0.031 14.4 12.7 1.5 9.0 0.5 3.1 2 1 1 3 3 3 0 Caudovirales tail fibre assembly protein, lambda gpK DUF896 PF05979.12 KOO23696.1 - 0.045 13.6 9.8 0.97 9.3 0.2 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF896) PgaD PF13994.6 KOO23696.1 - 0.34 10.9 1.5 2.5 8.1 0.1 2.3 2 1 1 3 3 3 0 PgaD-like protein HTH_32 PF13565.6 KOO23696.1 - 2.1 9.0 4.5 56 4.4 0.6 3.0 1 1 2 3 3 3 0 Homeodomain-like domain PspB PF06667.12 KOO23696.1 - 2.4 8.3 8.2 1.6 8.8 0.3 3.3 2 2 2 4 4 4 0 Phage shock protein B Gluconate_2-dh3 PF13618.6 KOO23696.1 - 5.5 7.2 6.4 21 5.3 6.4 1.9 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 AF-4 PF05110.13 KOO23697.1 - 0.5 8.4 13.4 0.77 7.8 13.4 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein BSP_II PF05432.11 KOO23697.1 - 1.3 8.7 20.2 2.2 7.9 20.2 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CiPC PF15800.5 KOO23697.1 - 5.4 6.6 6.3 1.1e+02 2.3 5.3 2.5 3 0 0 3 3 3 0 Clock interacting protein circadian Exo_endo_phos PF03372.23 KOO23698.1 - 6.5e-08 32.4 0.0 1.8e-07 30.9 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TilS PF09179.11 KOO23698.1 - 0.14 12.6 0.2 0.14 12.6 0.2 3.4 4 0 0 4 4 4 0 TilS substrate binding domain SNF2_N PF00176.23 KOO23699.1 - 5.6e-27 94.4 0.0 8.6e-21 74.0 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO23699.1 - 1.9e-12 47.5 0.0 3.1e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO23699.1 - 0.0002 21.4 0.0 0.0003 20.8 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO23699.1 - 0.011 15.6 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase 2OG-FeII_Oxy_3 PF13640.6 KOO23701.1 - 1.1e-05 26.3 0.0 2e-05 25.4 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO23702.1 - 0.00013 22.4 4.7 0.00013 22.4 4.7 2.6 2 1 0 2 2 2 1 ShK domain-like HC2 PF07382.11 KOO23702.1 - 0.0077 16.3 27.5 0.0077 16.3 27.5 3.3 2 1 0 3 3 3 2 Histone H1-like nucleoprotein HC2 Aha1_N PF09229.11 KOO23703.1 - 6.6e-08 32.9 0.0 9.7e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal SUKH-4 PF14435.6 KOO23703.1 - 4.7 7.2 10.8 34 4.4 0.1 2.2 1 1 1 2 2 2 0 SUKH-4 immunity protein DNase_II PF03265.15 KOO23704.1 - 2e-61 208.1 0.0 2.9e-61 207.6 0.0 1.2 1 0 0 1 1 1 1 Deoxyribonuclease II KinB_sensor PF16767.5 KOO23704.1 - 0.074 13.5 0.2 0.17 12.4 0.2 1.5 1 0 0 1 1 1 0 Sensor domain of alginate biosynthesis sensor protein KinB Sec63 PF02889.16 KOO23705.1 - 1e-14 54.4 0.0 1.1e-14 54.2 0.0 1.0 1 0 0 1 1 1 1 Sec63 Brl domain AAA_6 PF12774.7 KOO23706.1 - 1.5e-158 527.0 0.0 1.9e-157 523.3 0.0 2.6 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO23706.1 - 1.7e-123 412.7 0.1 1.7e-123 412.7 0.1 3.3 3 0 0 3 3 2 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO23706.1 - 4.5e-102 340.8 0.0 1e-100 336.4 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KOO23706.1 - 9.3e-90 300.9 0.0 2.7e-89 299.4 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KOO23706.1 - 1.1e-87 292.8 1.1 1.1e-87 292.8 1.1 2.6 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 KOO23706.1 - 3.5e-66 222.2 5.0 1.6e-63 213.5 0.0 4.3 5 0 0 5 5 4 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KOO23706.1 - 4.1e-47 160.0 0.0 1.1e-46 158.7 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 KOO23706.1 - 2.6e-44 151.7 19.2 7.4e-44 150.2 18.1 2.2 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KOO23706.1 - 5.1e-41 139.5 0.0 4.6e-39 133.2 0.0 3.4 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 KOO23706.1 - 1.1e-19 70.8 0.1 0.00026 21.0 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 KOO23706.1 - 4e-16 59.1 0.0 1.4e-15 57.3 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KOO23706.1 - 1.5e-08 35.2 2.6 0.073 13.4 0.0 5.5 5 0 0 5 5 4 3 AAA ATPase domain AAA_22 PF13401.6 KOO23706.1 - 3.8e-07 30.5 0.1 0.05 13.9 0.0 5.2 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 KOO23706.1 - 4.7e-07 30.3 0.6 0.77 10.2 0.0 4.7 5 0 0 5 5 3 2 ATPase family associated with various cellular activities (AAA) Dynein_AAA_lid PF17852.1 KOO23706.1 - 2e-06 27.9 0.0 6.5e-06 26.2 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_30 PF13604.6 KOO23706.1 - 5.4e-06 26.2 0.1 1 9.0 0.0 3.9 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 KOO23706.1 - 6.3e-06 26.5 0.3 0.11 12.9 0.0 4.4 4 0 0 4 4 3 1 RNA helicase HrpB7 PF09486.10 KOO23706.1 - 0.0025 18.2 2.6 0.0025 18.2 2.6 3.4 3 0 0 3 3 3 1 Bacterial type III secretion protein (HrpB7) TsaE PF02367.17 KOO23706.1 - 0.0044 17.0 5.5 0.062 13.3 0.1 3.9 4 0 0 4 4 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 KOO23706.1 - 0.007 16.3 4.0 0.058 13.3 0.0 3.6 4 0 0 4 4 4 1 NACHT domain DUF815 PF05673.13 KOO23706.1 - 0.011 14.9 0.0 0.25 10.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 KOO23706.1 - 0.017 14.9 0.2 0.14 11.8 0.0 2.6 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_18 PF13238.6 KOO23706.1 - 0.026 15.0 0.0 1.3 9.6 0.0 3.6 3 0 0 3 3 2 0 AAA domain T2SSE PF00437.20 KOO23706.1 - 0.031 13.3 1.5 1.4 7.9 0.0 3.4 4 0 0 4 4 4 0 Type II/IV secretion system protein ABC_tran PF00005.27 KOO23706.1 - 0.051 14.1 1.9 1.9 9.0 0.0 4.1 4 0 0 4 4 3 0 ABC transporter AAA_19 PF13245.6 KOO23706.1 - 0.055 13.8 0.1 25 5.2 0.0 3.5 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOO23706.1 - 0.069 12.9 0.2 4.9 7.0 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain TniB PF05621.11 KOO23706.1 - 0.085 12.3 0.0 0.57 9.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein Self-incomp_S1 PF05938.11 KOO23706.1 - 0.13 12.8 0.8 0.28 11.7 0.2 1.8 2 0 0 2 2 1 0 Plant self-incompatibility protein S1 AAA_33 PF13671.6 KOO23706.1 - 0.22 11.7 3.2 7.6 6.7 0.1 3.7 4 0 0 4 4 3 0 AAA domain Mg_chelatase PF01078.21 KOO23706.1 - 0.48 9.8 6.3 0.74 9.2 0.0 3.5 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI DHR10 PF18595.1 KOO23706.1 - 1.1 9.3 31.4 0.024 14.7 11.0 4.3 4 0 0 4 4 4 0 Designed helical repeat protein 10 domain ATG16 PF08614.11 KOO23706.1 - 4.6 7.4 18.7 0.25 11.5 5.1 3.6 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Helicase_PWI PF18149.1 KOO23707.1 - 1.5e-31 108.8 0.0 3.1e-30 104.6 0.0 2.6 2 0 0 2 2 2 1 N-terminal helicase PWI domain DEAD PF00270.29 KOO23707.1 - 1.2e-27 96.8 0.9 2.5e-27 95.8 0.9 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO23707.1 - 3.5e-13 49.9 0.0 8.1e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOO23707.1 - 0.0028 17.9 2.8 0.0029 17.9 0.1 2.4 3 1 0 3 3 3 1 AAA domain DUF148 PF02520.17 KOO23707.1 - 0.02 15.0 1.9 3.6 7.7 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function DUF148 AAA_19 PF13245.6 KOO23707.1 - 0.044 14.1 0.4 0.044 14.1 0.4 1.7 2 0 0 2 2 2 0 AAA domain RsbRD_N PF14361.6 KOO23707.1 - 0.051 14.3 3.5 0.12 13.0 2.0 2.3 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain AAA_11 PF13086.6 KOO23707.1 - 2.5 7.8 4.9 1.4 8.6 0.0 2.6 3 1 1 4 4 4 0 AAA domain Sec63 PF02889.16 KOO23708.1 - 2.4e-142 472.6 0.0 1.2e-86 290.1 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 KOO23708.1 - 2.9e-18 66.3 0.0 6.5e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO23708.1 - 4.5e-12 46.3 0.0 3e-08 34.0 0.0 3.4 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 KOO23708.1 - 3e-07 30.6 0.0 1.1e-06 28.8 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KOO23708.1 - 0.00068 19.4 0.0 0.24 11.1 0.0 2.5 1 1 1 2 2 2 2 AAA domain HHH_5 PF14520.6 KOO23708.1 - 0.015 15.9 0.0 0.062 13.9 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix domain AAA_19 PF13245.6 KOO23708.1 - 0.065 13.6 0.0 0.19 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC1 PF03109.16 KOO23710.1 - 2.8e-30 104.9 0.1 5.1e-30 104.1 0.1 1.5 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 KOO23710.1 - 0.0054 16.1 0.0 0.068 12.5 0.0 2.1 1 1 0 2 2 2 1 Protein kinase domain APH PF01636.23 KOO23710.1 - 0.0097 15.9 9.7 0.016 15.2 0.1 3.5 3 1 1 4 4 4 2 Phosphotransferase enzyme family Nop PF01798.18 KOO23711.1 - 2.6e-84 282.3 0.2 3.6e-84 281.8 0.2 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 KOO23711.1 - 1.2e-18 67.2 0.6 2.3e-18 66.3 0.6 1.5 1 0 0 1 1 1 1 NOP5NT (NUC127) domain MCM PF00493.23 KOO23712.1 - 8.2e-89 296.5 1.1 6.9e-87 290.2 0.1 2.9 2 1 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 KOO23712.1 - 4.3e-36 123.5 7.5 9.4e-36 122.4 1.5 2.6 3 0 0 3 3 3 1 MCM OB domain MCM_lid PF17855.1 KOO23712.1 - 4.1e-26 91.2 9.3 1.4e-14 54.2 1.5 3.3 2 1 1 3 3 3 2 MCM AAA-lid domain MCM_N PF14551.6 KOO23712.1 - 1.2e-13 51.6 0.1 3.3e-13 50.1 0.1 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KOO23712.1 - 2.4e-05 23.8 0.0 7.3e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KOO23712.1 - 0.00087 19.2 0.0 0.0027 17.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO23712.1 - 0.017 15.1 0.1 0.057 13.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TAL_FSA PF00923.19 KOO23713.1 - 5.3e-31 108.0 0.0 2.5e-29 102.5 0.0 2.0 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Zeta_toxin PF06414.12 KOO23714.1 - 5e-13 48.8 0.3 2.5e-08 33.4 0.0 3.2 3 0 0 3 3 3 2 Zeta toxin LRR_8 PF13855.6 KOO23714.1 - 8e-13 48.0 6.9 1.6e-05 24.5 0.2 3.5 2 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KOO23714.1 - 2.2e-11 43.8 11.8 0.00035 20.9 1.4 4.8 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO23714.1 - 4e-07 29.7 5.9 5.5 8.0 0.3 6.3 6 0 0 6 6 6 1 Leucine Rich Repeat AAA_33 PF13671.6 KOO23714.1 - 1.1e-05 25.6 0.0 0.00015 21.9 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO23714.1 - 0.0027 18.1 1.9 0.024 15.0 0.0 3.4 4 0 0 4 4 4 1 AAA ATPase domain IQ PF00612.27 KOO23714.1 - 0.0064 16.2 0.2 11 6.2 0.0 3.5 3 0 0 3 3 3 0 IQ calmodulin-binding motif LRR_9 PF14580.6 KOO23714.1 - 0.0073 15.8 0.2 2.6 7.5 0.0 2.5 2 0 0 2 2 2 1 Leucine-rich repeat AAA_22 PF13401.6 KOO23714.1 - 0.018 15.3 0.0 0.2 11.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 KOO23714.1 - 0.02 14.8 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA PF00004.29 KOO23714.1 - 0.03 14.8 0.0 0.28 11.6 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KOO23714.1 - 0.031 14.8 0.3 0.53 10.8 0.0 3.2 3 0 0 3 3 2 0 AAA domain Viral_helicase1 PF01443.18 KOO23714.1 - 0.076 12.7 0.0 0.3 10.8 0.0 2.0 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 KOO23714.1 - 0.076 13.4 0.0 0.45 10.9 0.0 2.3 2 0 0 2 2 2 0 RNA helicase Leucyl-specific PF14795.6 KOO23714.1 - 0.55 10.3 2.3 0.96 9.6 0.1 2.8 2 0 0 2 2 1 0 Leucine-tRNA synthetase-specific domain ABC_tran PF00005.27 KOO23714.1 - 0.56 10.7 0.0 0.56 10.7 0.0 3.4 5 0 0 5 5 3 0 ABC transporter ATPase_2 PF01637.18 KOO23714.1 - 1.1 9.1 0.0 1.1 9.1 0.0 2.7 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea Prp19 PF08606.11 KOO23714.1 - 3.1 7.8 7.2 24 5.0 0.8 3.5 2 0 0 2 2 2 0 Prp19/Pso4-like YdfA_immunity PF12127.8 KOO23714.1 - 6.2 5.8 32.1 4 6.4 7.1 3.3 2 1 1 3 3 3 0 SigmaW regulon antibacterial Glyco_transf_29 PF00777.18 KOO23715.1 - 6.9e-08 32.2 0.0 8.8e-07 28.6 0.0 2.3 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) XRN_N PF03159.18 KOO23716.1 - 1.3e-28 100.0 0.0 2.8e-28 99.0 0.0 1.6 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus IBR PF01485.21 KOO23716.1 - 1.3e-13 50.9 26.5 3.9e-09 36.6 4.3 3.4 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain XRN_M PF17846.1 KOO23716.1 - 0.00075 18.6 0.0 0.0067 15.4 0.0 2.1 2 0 0 2 2 2 1 Xrn1 helical domain EF-hand_5 PF13202.6 KOO23717.1 - 0.00068 19.0 0.0 0.0014 18.0 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO23717.1 - 0.0013 19.2 0.0 0.0026 18.1 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO23717.1 - 0.0015 17.9 0.0 0.0039 16.6 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO23717.1 - 0.032 14.2 0.0 0.095 12.7 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.6 KOO23717.1 - 0.035 14.0 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair DUF4326 PF14216.6 KOO23718.1 - 2.7e-08 34.4 0.2 6.3e-07 30.0 0.1 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4326) zf-BED PF02892.15 KOO23719.1 - 0.0049 16.9 0.3 0.0096 15.9 0.3 1.4 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_4 PF13894.6 KOO23719.1 - 0.0074 17.0 1.1 0.022 15.6 1.1 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 KOO23719.1 - 0.21 12.1 5.5 0.064 13.7 1.9 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3431 PF11913.8 KOO23720.1 - 0.00042 20.2 0.0 0.53 10.0 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3431) Dendrin PF15498.6 KOO23721.1 - 0.85 8.3 5.1 1.2 7.8 5.1 1.2 1 0 0 1 1 1 0 Nephrin and CD2AP-binding protein, Dendrin IQ PF00612.27 KOO23722.1 - 0.014 15.2 0.8 0.049 13.4 0.8 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif Arm PF00514.23 KOO23723.1 - 1.4e-202 650.5 190.8 4.6e-11 42.4 0.0 58.2 62 0 0 62 62 60 41 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 KOO23723.1 - 1.5e-29 103.3 8.5 0.015 14.6 0.0 14.3 6 3 6 14 14 14 9 V-ATPase subunit H Atx10homo_assoc PF09759.9 KOO23723.1 - 1.6e-27 95.4 25.5 0.00022 21.2 0.3 17.4 18 2 2 20 20 20 7 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.7 KOO23723.1 - 1.6e-22 80.3 12.1 0.096 12.7 0.0 14.6 12 4 4 16 16 16 5 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOO23723.1 - 1.4e-14 54.2 176.2 5.9e-06 26.6 1.9 25.4 13 6 15 30 30 30 14 HEAT repeats Adaptin_N PF01602.20 KOO23723.1 - 2.5e-11 42.9 21.1 1.8 7.1 0.1 11.7 8 5 2 10 10 10 4 Adaptin N terminal region Arm_2 PF04826.13 KOO23723.1 - 1.6e-10 40.9 32.1 0.069 12.6 0.2 15.2 8 5 11 20 20 20 2 Armadillo-like V-ATPase_H_C PF11698.8 KOO23723.1 - 1.4e-06 28.4 18.0 0.097 12.8 0.0 9.5 12 0 0 12 12 11 2 V-ATPase subunit H DUF5578 PF17741.1 KOO23723.1 - 2.4e-06 27.2 52.1 0.65 9.4 0.1 15.3 8 3 11 19 19 19 4 Family of unknown function (DUF5578) HEAT_EZ PF13513.6 KOO23723.1 - 2.4e-06 27.9 156.3 2.2 8.9 0.3 31.9 25 8 7 34 34 32 9 HEAT-like repeat KAP PF05804.12 KOO23723.1 - 0.0035 15.6 0.0 1.1 7.3 0.0 4.9 7 1 0 7 7 7 1 Kinesin-associated protein (KAP) DUF3361 PF11841.8 KOO23723.1 - 0.1 12.5 28.7 8.1 6.4 0.0 10.5 12 0 0 12 12 12 0 Domain of unknown function (DUF3361) DUF913 PF06025.12 KOO23723.1 - 0.57 9.1 4.2 17 4.2 0.0 5.2 6 1 1 7 7 7 0 Domain of Unknown Function (DUF913) SASA PF03629.18 KOO23724.1 - 3.9e-17 62.7 0.0 1.9e-16 60.4 0.0 2.0 1 1 0 1 1 1 1 Carbohydrate esterase, sialic acid-specific acetylesterase DUF3456 PF11938.8 KOO23725.1 - 0.51 10.8 5.8 5.1 7.6 5.8 2.3 1 1 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP RNA_lig_T4_1 PF09511.10 KOO23726.1 - 3e-12 46.9 0.0 4.6e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 RNA ligase FA_desaturase PF00487.24 KOO23727.1 - 6.1e-32 111.5 24.2 8.6e-32 111.0 24.2 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Amino_oxidase PF01593.24 KOO23728.1 - 3e-18 66.4 1.6 1.3e-14 54.4 0.0 2.8 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO23728.1 - 1.8e-14 53.7 0.1 4.9e-14 52.3 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO23728.1 - 2.8e-06 26.7 3.0 6.8e-06 25.4 0.3 2.6 3 0 0 3 3 3 1 FAD binding domain FAD_oxidored PF12831.7 KOO23728.1 - 0.0001 21.8 0.1 0.00017 21.1 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 KOO23728.1 - 0.00017 21.3 0.4 0.00017 21.3 0.4 2.3 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOO23728.1 - 0.00033 20.0 0.1 0.00088 18.6 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOO23728.1 - 0.0005 19.4 0.1 0.0013 18.1 0.1 1.6 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 KOO23728.1 - 0.00052 20.0 0.0 0.0036 17.3 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 KOO23728.1 - 0.00067 19.0 0.1 0.13 11.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO23728.1 - 0.004 17.7 0.2 0.011 16.3 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO23728.1 - 0.0076 15.0 0.2 0.012 14.3 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 KOO23728.1 - 0.012 14.9 0.1 0.019 14.2 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 KOO23728.1 - 0.038 13.3 0.0 0.082 12.2 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 KOO23728.1 - 0.043 12.9 0.5 0.08 12.0 0.5 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A MCRA PF06100.11 KOO23728.1 - 0.094 11.5 0.0 0.21 10.3 0.0 1.5 2 0 0 2 2 2 0 MCRA family CMAS PF02353.20 KOO23729.1 - 2.4e-75 253.4 0.2 3e-75 253.0 0.2 1.0 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 KOO23729.1 - 1.5e-09 38.4 0.1 4.7e-09 36.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO23729.1 - 1.1e-07 31.8 0.0 2e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23729.1 - 6.7e-05 23.6 0.0 0.00015 22.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO23729.1 - 0.0054 16.5 0.1 0.016 15.0 0.1 1.6 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOO23729.1 - 0.007 16.2 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO23729.1 - 0.03 13.9 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain RrnaAD PF00398.20 KOO23729.1 - 0.11 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PARP PF00644.20 KOO23732.1 - 3.3e-18 66.0 0.0 3.6e-15 56.1 0.0 2.3 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Macro PF01661.21 KOO23732.1 - 1.6e-16 60.4 0.2 4e-16 59.1 0.2 1.6 1 0 0 1 1 1 1 Macro domain NYN PF01936.18 KOO23732.1 - 0.055 13.9 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 NYN domain DUF3540 PF12059.8 KOO23732.1 - 0.29 10.9 1.9 0.32 10.8 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3540) CAP_N PF01213.19 KOO23732.1 - 1.8 7.9 8.4 5 6.5 8.4 1.7 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 KOO23732.1 - 3.9 7.5 11.3 13 5.9 8.2 2.8 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 cNMP_binding PF00027.29 KOO23734.1 - 0.00083 19.4 0.0 0.0037 17.3 0.0 2.0 2 1 0 2 2 2 1 Cyclic nucleotide-binding domain APOBEC_N PF08210.11 KOO23735.1 - 1.8e-11 44.3 0.0 2.7e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain RRM_1 PF00076.22 KOO23735.1 - 2.9e-05 23.8 0.0 0.051 13.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) APOBEC4 PF18775.1 KOO23735.1 - 0.0036 17.4 0.0 0.22 11.7 0.0 2.9 2 1 0 2 2 2 1 APOBEC4 Sec63 PF02889.16 KOO23736.1 - 7.3e-112 372.7 0.0 5e-64 215.9 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 KOO23736.1 - 2.8e-32 111.9 0.0 2.9e-20 72.8 0.0 2.8 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 KOO23736.1 - 3.5e-13 49.9 0.0 7.7e-09 35.8 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOO23736.1 - 5.8e-11 42.7 0.0 3.7e-05 24.0 0.0 3.7 3 1 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOO23736.1 - 9.1e-06 26.0 0.0 0.0016 18.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KOO23736.1 - 0.0031 16.6 0.0 0.0068 15.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein Nucleoporin_N PF08801.11 KOO23737.1 - 2.7e-50 171.4 0.0 4e-50 170.8 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like SurA_N_3 PF13624.6 KOO23737.1 - 0.11 12.2 0.9 0.21 11.4 0.9 1.4 1 0 0 1 1 1 0 SurA N-terminal domain DKCLD PF08068.12 KOO23738.1 - 2.3e-34 117.3 0.3 1.1e-32 111.8 0.2 2.4 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 KOO23738.1 - 3.6e-24 85.8 0.8 2.3e-21 76.7 0.8 3.2 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 KOO23738.1 - 6.7e-21 74.2 0.8 1.4e-20 73.1 0.8 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 KOO23738.1 - 4e-20 71.6 2.2 7.9e-20 70.6 2.2 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 KOO23738.1 - 0.054 13.8 0.0 0.17 12.2 0.0 1.9 2 0 0 2 2 2 0 UPF0113 PUA domain YL1 PF05764.13 KOO23738.1 - 2.4 8.2 18.4 4 7.5 18.4 1.3 1 0 0 1 1 1 0 YL1 nuclear protein SNF2_N PF00176.23 KOO23739.1 - 3.9e-48 164.0 0.0 6e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO23739.1 - 3.4e-14 53.1 0.0 1e-13 51.6 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO23739.1 - 0.00048 20.2 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO23739.1 - 0.00072 19.4 0.2 0.0024 17.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 KOO23739.1 - 0.067 12.3 0.0 0.31 10.2 0.0 1.9 1 1 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 LRR_6 PF13516.6 KOO23741.1 - 1.7e-14 52.5 12.5 0.00038 20.3 0.2 4.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 KOO23741.1 - 0.0012 19.2 5.0 0.15 12.5 0.5 3.1 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) Ank_2 PF12796.7 KOO23742.1 - 4.1e-31 107.4 0.5 1.7e-11 44.6 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO23742.1 - 1.4e-25 89.3 0.6 5e-10 39.7 0.0 5.7 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO23742.1 - 2.9e-23 81.2 6.7 0.00041 20.7 0.1 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.6 KOO23742.1 - 1.3e-18 65.1 2.8 0.001 19.4 0.0 6.6 6 1 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 KOO23742.1 - 7.4e-17 61.2 1.1 6.8e-05 23.1 0.0 5.3 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Pkinase PF00069.25 KOO23743.1 - 3.8e-53 180.5 0.0 5.7e-53 180.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23743.1 - 1.7e-18 66.9 0.0 2.7e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO23743.1 - 0.0012 18.9 2.9 0.0074 16.2 0.1 2.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Herpes_LP PF03363.13 KOO23743.1 - 0.011 15.5 0.2 0.022 14.6 0.2 1.4 1 0 0 1 1 1 0 Herpesvirus leader protein Choline_kinase PF01633.20 KOO23743.1 - 0.021 14.4 0.1 0.041 13.5 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase UPF0564 PF10595.9 KOO23744.1 - 0.017 14.2 0.3 0.021 13.9 0.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 CMAS PF02353.20 KOO23745.1 - 5.4e-13 48.9 0.0 8.4e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 KOO23745.1 - 2.3e-08 34.0 0.0 3.5e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO23745.1 - 2.8e-07 30.5 0.0 4.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23745.1 - 1.4e-06 28.9 0.0 2.6e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO23745.1 - 1.9e-06 28.5 0.0 3.9e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO23745.1 - 3.4e-05 24.4 0.0 7.6e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOO23745.1 - 0.00027 20.5 0.0 0.00044 19.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 KOO23745.1 - 0.00058 19.4 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain DUF938 PF06080.12 KOO23745.1 - 0.003 17.4 0.0 0.0044 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Ank_2 PF12796.7 KOO23746.1 - 8.4e-35 119.2 10.6 3.2e-13 50.1 1.4 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO23746.1 - 1e-20 73.8 2.9 1.9e-09 37.8 0.3 3.2 3 0 0 3 3 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO23746.1 - 3.7e-20 71.7 4.2 5.8e-08 32.9 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO23746.1 - 8.6e-19 67.1 12.5 1e-06 28.9 0.0 5.4 4 1 1 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KOO23746.1 - 9e-13 47.2 5.4 0.011 16.2 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeat TPR_2 PF07719.17 KOO23746.1 - 2e-07 30.6 9.1 0.0046 17.0 0.7 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23746.1 - 3e-07 30.0 5.9 0.001 18.8 0.7 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23746.1 - 3.7e-05 23.9 4.8 5.1e-05 23.5 0.8 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23746.1 - 9e-05 22.1 0.1 0.0002 21.0 0.1 1.6 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.6 KOO23746.1 - 0.0012 19.5 0.6 0.0012 19.5 0.6 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23746.1 - 0.0012 18.7 0.9 0.47 10.6 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23746.1 - 0.0044 17.5 0.8 0.018 15.5 0.8 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23746.1 - 0.0071 17.1 3.2 0.99 10.4 0.5 3.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO23746.1 - 0.022 14.7 1.1 0.12 12.3 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Aha1_N PF09229.11 KOO23746.1 - 0.077 13.2 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Activator of Hsp90 ATPase, N-terminal TPR_8 PF13181.6 KOO23746.1 - 0.095 13.0 0.3 0.35 11.2 0.3 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat DivIVA PF05103.13 KOO23747.1 - 0.86 9.7 5.7 2.6 8.1 5.7 1.8 1 0 0 1 1 1 0 DivIVA protein MgtE PF01769.16 KOO23748.1 - 2.4e-19 69.9 6.7 3.9e-19 69.2 6.7 1.3 1 0 0 1 1 1 1 Divalent cation transporter Baculo_gp64 PF03273.13 KOO23748.1 - 0.072 11.9 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family bZIP_2 PF07716.15 KOO23748.1 - 0.075 13.1 0.6 0.14 12.3 0.6 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Surfac_D-trimer PF09006.11 KOO23748.1 - 0.14 12.1 0.7 0.46 10.4 0.5 1.9 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation FSIP1 PF15554.6 KOO23749.1 - 0.013 14.7 3.1 0.37 9.9 0.0 2.2 2 0 0 2 2 2 0 FSIP1 family Borrelia_P83 PF05262.11 KOO23750.1 - 1.6 7.1 11.1 2.4 6.5 11.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein PSD2 PF07624.11 KOO23751.1 - 0.025 14.3 0.3 0.057 13.2 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1585) DUF4407 PF14362.6 KOO23752.1 - 0.014 14.8 2.6 0.016 14.6 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FEZ PF07763.13 KOO23752.1 - 0.033 13.9 1.3 0.041 13.6 1.3 1.0 1 0 0 1 1 1 0 FEZ-like protein zf-CCHC PF00098.23 KOO23753.1 - 3.5e-07 30.0 15.2 0.00047 20.1 3.3 2.5 2 0 0 2 2 2 2 Zinc knuckle DUF4101 PF13355.6 KOO23753.1 - 0.033 14.6 0.6 0.11 13.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4101) zf-CCHC_2 PF13696.6 KOO23753.1 - 0.07 13.0 12.5 0.08 12.8 0.5 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KOO23753.1 - 0.13 12.0 7.0 0.16 11.7 0.6 2.4 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 KOO23753.1 - 0.39 10.5 16.6 1.8 8.3 0.0 3.4 2 1 1 3 3 3 0 GAG-polyprotein viral zinc-finger YyzF PF14116.6 KOO23753.1 - 0.53 10.4 4.4 6.8 6.8 0.5 2.6 1 1 1 2 2 2 0 YyzF-like protein DUF702 PF05142.12 KOO23753.1 - 0.56 10.7 12.6 0.13 12.8 9.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Proteasome PF00227.26 KOO23754.1 - 5.4e-45 153.2 0.0 7.3e-45 152.8 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOO23754.1 - 7e-15 54.4 0.4 1.2e-14 53.6 0.4 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Pkinase PF00069.25 KOO23755.1 - 8.7e-74 248.2 0.0 1.1e-73 247.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23755.1 - 4.4e-43 147.4 0.0 6.7e-43 146.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Arm PF00514.23 KOO23755.1 - 2.7e-06 27.2 2.0 3.4e-05 23.7 0.1 3.4 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Kinase-like PF14531.6 KOO23755.1 - 2.1e-05 24.0 0.0 3.3e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO23755.1 - 3.9e-05 22.6 0.0 6.8e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase HEAT PF02985.22 KOO23755.1 - 0.0053 16.9 0.2 0.26 11.6 0.0 4.0 4 0 0 4 4 4 1 HEAT repeat Haspin_kinase PF12330.8 KOO23755.1 - 0.037 13.0 0.0 0.072 12.0 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 KOO23755.1 - 0.044 13.4 0.1 0.071 12.7 0.1 1.2 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 KOO23755.1 - 0.078 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HEAT_EZ PF13513.6 KOO23755.1 - 0.26 11.8 9.0 0.66 10.6 0.1 4.9 3 1 1 4 4 4 0 HEAT-like repeat Rho_GDI PF02115.17 KOO23756.1 - 0.00046 20.0 0.0 0.00065 19.5 0.0 1.2 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor CCDC53 PF10152.9 KOO23756.1 - 0.074 13.5 0.2 0.11 12.9 0.2 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex BATS PF06968.13 KOO23757.1 - 1.3e-18 66.9 0.1 5.2e-18 65.0 0.0 2.1 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 KOO23757.1 - 2.8e-13 50.6 0.3 5.1e-13 49.7 0.3 1.5 1 0 0 1 1 1 1 Radical SAM superfamily DUF4157 PF13699.6 KOO23757.1 - 0.9 9.8 5.7 0.72 10.1 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4157) Phasin_2 PF09361.10 KOO23758.1 - 0.29 11.4 3.1 0.98 9.7 3.1 1.9 1 0 0 1 1 1 0 Phasin protein PhyH PF05721.13 KOO23759.1 - 2e-23 83.8 0.0 3.9e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 KOO23759.1 - 0.00011 23.1 0.0 0.00027 21.8 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HD PF01966.22 KOO23759.1 - 0.0002 21.6 1.5 0.0054 17.0 1.3 2.3 2 0 0 2 2 2 1 HD domain 2OG-FeII_Oxy_5 PF13759.6 KOO23759.1 - 0.0019 18.6 0.0 0.028 14.8 0.0 2.4 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase MIOX PF05153.15 KOO23759.1 - 0.013 15.1 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Myo-inositol oxygenase HDOD PF08668.12 KOO23759.1 - 0.11 11.9 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 HDOD domain fn3 PF00041.21 KOO23760.1 - 2.9e-60 200.6 26.0 4.1e-07 30.3 0.2 13.5 13 2 0 13 13 13 10 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KOO23760.1 - 1.1e-10 41.9 20.5 5.1e-06 27.0 0.2 9.5 9 2 0 9 9 9 3 Purple acid Phosphatase, N-terminal domain Arf PF00025.21 KOO23761.1 - 2.1e-31 108.7 0.0 2.9e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOO23761.1 - 5e-07 29.5 0.0 4.1e-06 26.5 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KOO23761.1 - 7.4e-07 28.8 0.0 1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOO23761.1 - 1e-06 28.3 0.0 1.3e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 KOO23761.1 - 7.1e-06 26.2 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KOO23761.1 - 1.3e-05 25.2 0.0 1.9e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 KOO23761.1 - 0.00013 21.6 0.0 0.00022 20.9 0.0 1.4 1 1 0 1 1 1 1 Ras family G-alpha PF00503.20 KOO23761.1 - 0.0057 15.9 0.0 0.053 12.7 0.0 2.1 2 1 0 2 2 2 1 G-protein alpha subunit AAA_25 PF13481.6 KOO23761.1 - 0.0067 16.0 0.3 0.01 15.4 0.3 1.3 1 0 0 1 1 1 1 AAA domain adh_short PF00106.25 KOO23762.1 - 1.9e-24 86.2 1.6 2.6e-18 66.2 0.6 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO23762.1 - 6.5e-16 58.6 2.6 1.2e-10 41.3 2.4 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO23762.1 - 4.6e-07 29.9 1.4 1e-06 28.8 1.3 1.6 1 1 1 2 2 2 1 KR domain EF-hand_6 PF13405.6 KOO23763.1 - 1.1e-12 46.7 0.8 0.00024 20.8 0.1 4.1 3 1 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KOO23763.1 - 2.9e-12 45.5 4.8 1.4e-06 27.5 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO23763.1 - 4.6e-12 46.2 0.3 1.8e-09 37.9 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO23763.1 - 5.9e-12 44.2 0.7 0.00019 20.8 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO23763.1 - 1.4e-08 34.4 2.2 8.5e-07 28.7 0.1 3.3 2 2 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO23763.1 - 0.0011 19.2 0.1 0.0026 18.1 0.1 1.7 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO23763.1 - 0.0043 17.9 0.0 0.019 15.8 0.0 1.9 1 1 1 2 2 2 1 EF-hand domain EF-hand_10 PF14788.6 KOO23763.1 - 0.024 14.5 0.0 0.051 13.4 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_4 PF12763.7 KOO23763.1 - 0.088 12.8 0.1 0.6 10.1 0.1 2.2 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand LuxE PF04443.12 KOO23764.1 - 0.22 10.5 0.5 0.86 8.6 0.2 1.8 1 1 1 2 2 2 0 Acyl-protein synthetase, LuxE HALZ PF02183.18 KOO23765.1 - 0.32 11.3 0.0 0.32 11.3 0.0 6.6 7 1 0 7 7 7 0 Homeobox associated leucine zipper DRY_EERY PF09750.9 KOO23765.1 - 5.3 7.3 7.7 0.86 9.9 1.3 2.9 2 0 0 2 2 2 0 Alternative splicing regulator MDM10 PF12519.8 KOO23766.1 - 0.008 15.1 2.8 0.01 14.7 2.8 1.2 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 RR_TM4-6 PF06459.12 KOO23766.1 - 3.6 7.3 10.8 5.1 6.8 10.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Atg14 PF10186.9 KOO23766.1 - 3.9 6.5 12.4 5.2 6.1 12.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Asp-B-Hydro_N PF05279.11 KOO23766.1 - 4.5 7.3 12.4 6.2 6.8 12.4 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Peptidase_M16_M PF16187.5 KOO23767.1 - 2.3e-59 201.0 0.0 3.1e-59 200.6 0.0 1.2 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 KOO23767.1 - 6.1e-39 133.4 0.0 4.9e-35 120.7 0.0 3.5 3 1 1 4 4 4 2 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOO23767.1 - 7.2e-29 101.1 0.0 4.9e-14 52.8 0.0 3.9 4 1 0 4 4 4 3 Peptidase M16 inactive domain Apolipoprotein PF01442.18 KOO23767.1 - 0.54 10.1 4.9 0.12 12.2 0.9 2.0 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain Creatininase PF02633.14 KOO23769.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Creatinine amidohydrolase CBM_26 PF16824.5 KOO23769.1 - 0.16 12.1 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 C-terminal carbohydrate-binding module DUF1564 PF07600.11 KOO23770.1 - 0.19 11.4 0.3 0.25 11.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1564) OAD_gamma PF04277.13 KOO23770.1 - 6.9 7.3 6.5 5 7.8 4.7 1.7 1 1 1 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Ribosomal_L2_C PF03947.18 KOO23771.1 - 8.5e-51 171.4 1.1 1.2e-50 170.9 1.1 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KOO23771.1 - 3.9e-21 74.8 0.1 6.9e-21 74.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain DUF4384 PF14326.6 KOO23771.1 - 0.17 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4384) EF-hand_6 PF13405.6 KOO23772.1 - 5.5e-20 69.5 1.1 5.7e-06 25.8 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO23772.1 - 2.9e-19 67.1 3.8 9.6e-06 24.8 0.0 4.8 5 0 0 5 5 5 3 EF hand EF-hand_5 PF13202.6 KOO23772.1 - 1.6e-17 62.1 4.1 2.2e-05 23.8 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO23772.1 - 5.4e-15 55.6 0.2 0.00049 20.5 0.0 3.8 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO23772.1 - 3.1e-13 49.4 1.0 5.3e-08 32.6 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair Barstar PF01337.18 KOO23772.1 - 0.16 12.0 0.1 1.7 8.7 0.0 2.8 2 1 1 3 3 3 0 Barstar (barnase inhibitor) KCNQ2_u3 PF16642.5 KOO23773.1 - 0.3 12.1 3.2 0.65 11.0 0.2 2.6 2 1 0 3 3 3 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Kinesin PF00225.23 KOO23774.1 - 8.4e-54 182.7 0.0 7.1e-34 117.2 0.0 2.1 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KOO23774.1 - 3.6e-21 75.7 0.0 5.9e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding bZIP_2 PF07716.15 KOO23774.1 - 0.065 13.3 1.3 0.13 12.4 0.3 2.0 2 0 0 2 2 2 0 Basic region leucine zipper TSC22 PF01166.18 KOO23774.1 - 0.2 12.0 1.3 0.76 10.1 0.6 2.4 2 1 0 2 2 2 0 TSC-22/dip/bun family CLP_protease PF00574.23 KOO23775.1 - 3.8e-75 251.8 1.3 4.5e-75 251.5 1.3 1.0 1 0 0 1 1 1 1 Clp protease VMA21 PF09446.10 KOO23776.1 - 7.5e-06 26.0 7.4 8.5e-06 25.8 7.4 1.0 1 0 0 1 1 1 1 VMA21-like domain PMP22_Claudin PF00822.20 KOO23776.1 - 0.00081 19.3 0.2 0.00081 19.3 0.2 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Oxidored_q3 PF00499.20 KOO23776.1 - 0.019 14.7 1.1 0.021 14.6 1.1 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Duffy_binding PF05424.11 KOO23777.1 - 0.2 11.7 0.4 0.33 11.0 0.4 1.2 1 0 0 1 1 1 0 Duffy binding domain Acyltransferase PF01553.21 KOO23778.1 - 7.4e-09 35.3 0.0 1.8e-07 30.9 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase COX8 PF02285.15 KOO23778.1 - 0.034 14.0 0.2 0.076 12.9 0.2 1.6 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIII Ion_trans PF00520.31 KOO23779.1 - 4.8e-12 45.6 0.0 8e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Ion transport protein C2 PF00168.30 KOO23779.1 - 1.7e-07 31.4 0.1 5.7e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 C2 domain cNMP_binding PF00027.29 KOO23779.1 - 0.00015 21.8 0.0 0.00028 20.9 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Mito_fiss_reg PF05308.11 KOO23781.1 - 5 7.1 6.6 7.5 6.6 6.6 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Ion_trans PF00520.31 KOO23783.1 - 1.2e-174 578.1 42.8 2.6e-51 174.2 1.0 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO23783.1 - 1.5e-10 40.4 48.1 7.7e-05 21.5 6.3 7.4 6 2 1 7 7 7 5 Polycystin cation channel HemY_N PF07219.13 KOO23783.1 - 0.65 10.2 2.2 3 8.1 0.0 3.4 3 0 0 3 3 3 0 HemY protein N-terminus ketoacyl-synt PF00109.26 KOO23785.1 - 6.6e-56 189.7 2.8 1.1e-55 189.0 0.0 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOO23785.1 - 1.3e-35 121.9 5.1 5.1e-35 120.1 4.4 2.5 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 KOO23785.1 - 3.1e-31 109.1 0.0 6.5e-31 108.0 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain AMP-binding PF00501.28 KOO23785.1 - 1.9e-28 99.2 0.0 4.8e-28 97.9 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme KR PF08659.10 KOO23785.1 - 2.4e-26 92.8 0.0 9.3e-26 90.8 0.0 2.1 2 0 0 2 2 2 1 KR domain PP-binding PF00550.25 KOO23785.1 - 1.9e-21 76.2 0.5 5.3e-12 45.9 0.1 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site Thioesterase PF00975.20 KOO23785.1 - 1.2e-12 48.5 2.0 5.3e-09 36.5 0.2 2.9 3 0 0 3 3 3 2 Thioesterase domain KAsynt_C_assoc PF16197.5 KOO23785.1 - 2.8e-08 34.2 0.0 7.7e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 KOO23785.1 - 0.00039 19.9 2.0 0.00039 19.9 0.4 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Epimerase PF01370.21 KOO23785.1 - 0.006 16.1 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 KOO23785.1 - 0.014 14.8 0.0 0.037 13.5 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase AMP-binding_C PF13193.6 KOO23785.1 - 0.038 15.0 0.1 0.26 12.3 0.1 2.6 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Hydrolase_4 PF12146.8 KOO23785.1 - 0.054 12.7 1.0 0.88 8.8 0.1 2.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO23785.1 - 0.083 12.5 0.2 0.66 9.6 0.0 2.4 3 0 0 3 3 3 0 alpha/beta hydrolase fold GDP_Man_Dehyd PF16363.5 KOO23785.1 - 0.096 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Abhydrolase_3 PF07859.13 KOO23785.1 - 5.8 6.7 11.1 0.046 13.6 0.7 2.7 3 0 0 3 3 3 0 alpha/beta hydrolase fold Glyco_hydro_1 PF00232.18 KOO23786.1 - 3e-151 503.9 0.0 4.1e-151 503.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 TPR_19 PF14559.6 KOO23787.1 - 0.0014 19.1 0.1 0.0033 17.9 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23787.1 - 0.14 12.8 0.3 0.14 12.8 0.3 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat PSD5 PF07637.11 KOO23787.1 - 0.59 10.5 4.3 0.33 11.3 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1595) FGGY_C PF02782.16 KOO23789.1 - 7.2e-29 100.9 2.7 9.9e-29 100.5 2.7 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 KOO23789.1 - 0.0033 17.0 0.0 0.0095 15.5 0.0 1.7 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain RHH_1 PF01402.21 KOO23789.1 - 0.19 11.7 0.1 32 4.7 0.1 2.6 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family DEAD PF00270.29 KOO23790.1 - 3.1e-47 160.6 0.0 8e-47 159.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO23790.1 - 2.2e-28 98.8 0.0 5.2e-28 97.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RRM_1 PF00076.22 KOO23790.1 - 0.00042 20.1 0.1 0.0013 18.5 0.1 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ResIII PF04851.15 KOO23790.1 - 0.0052 16.8 0.0 0.012 15.6 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HBS1_N PF08938.10 KOO23790.1 - 0.29 11.5 2.8 2.2 8.6 0.1 2.6 2 0 0 2 2 2 0 HBS1 N-terminus EELM2 PF15863.5 KOO23791.1 - 0.04 14.0 0.0 0.088 12.9 0.0 1.5 1 1 1 2 2 2 0 Extended EGL-27 and MTA1 homology domain 4PPT_N PF17837.1 KOO23791.1 - 0.048 13.8 0.3 0.37 10.9 0.0 2.3 1 1 2 3 3 3 0 4'-phosphopantetheinyl transferase N-terminal domain Ras PF00071.22 KOO23793.1 - 6.4e-61 204.7 0.0 7.8e-61 204.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO23793.1 - 1.1e-35 122.5 0.0 1.7e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO23793.1 - 1.1e-12 47.8 0.0 1.3e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO23793.1 - 3.2e-05 24.0 0.0 5.2e-05 23.3 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOO23793.1 - 0.00029 20.3 0.0 0.00036 20.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KOO23793.1 - 0.0015 18.5 0.3 0.44 10.4 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOO23793.1 - 0.0085 15.7 0.0 0.02 14.4 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KOO23793.1 - 0.018 15.4 0.1 0.026 14.9 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain Plus-3 PF03126.18 KOO23794.1 - 8.9e-09 35.9 0.0 2.6e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 Plus-3 domain BAH PF01426.18 KOO23794.1 - 1.1e-06 28.5 0.0 3.5e-06 26.9 0.0 1.9 1 1 0 1 1 1 1 BAH domain DEK_C PF08766.11 KOO23794.1 - 0.033 14.1 0.0 0.097 12.6 0.0 1.9 1 1 0 1 1 1 0 DEK C terminal domain RNA_pol_Rpc4 PF05132.14 KOO23794.1 - 4.3 7.7 8.6 1.8 9.0 0.8 2.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 TPR_1 PF00515.28 KOO23795.1 - 4.2e-46 153.0 6.1 3.2e-08 33.1 0.2 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23795.1 - 4.4e-36 120.1 13.5 7e-06 25.8 0.2 7.9 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23795.1 - 6.5e-33 110.2 4.9 2.4e-06 27.3 0.0 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23795.1 - 5.8e-28 96.3 8.6 3.4e-08 33.0 0.2 7.2 3 2 4 7 7 7 6 TPR repeat TPR_12 PF13424.6 KOO23795.1 - 4.8e-24 84.5 9.2 1.6e-06 28.3 0.1 6.3 3 3 2 5 5 5 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOO23795.1 - 3.1e-22 77.3 7.7 0.00075 19.7 0.1 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23795.1 - 8e-21 74.3 7.6 3.1e-09 37.2 0.1 5.5 3 2 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23795.1 - 2.5e-20 72.8 0.2 3.9e-06 27.4 0.0 5.4 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23795.1 - 1e-19 69.5 8.1 0.0048 17.6 0.0 7.3 3 1 5 8 8 7 6 Tetratricopeptide repeat TPR_9 PF13371.6 KOO23795.1 - 9e-19 67.4 1.0 1.2e-05 25.3 0.0 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23795.1 - 2.6e-14 52.1 8.3 0.0013 18.6 0.0 7.4 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO23795.1 - 9e-13 48.0 10.3 0.042 14.5 0.0 7.8 8 0 0 8 8 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO23795.1 - 1.3e-10 41.3 12.1 0.00026 21.1 0.1 4.6 3 3 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KOO23795.1 - 9.9e-10 38.0 5.9 7.5 6.6 0.0 7.2 7 0 0 7 7 7 0 Tetratricopeptide repeat ChAPs PF09295.10 KOO23795.1 - 1.8e-08 33.8 1.1 1.8e-05 24.0 0.2 2.5 1 1 1 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_15 PF13429.6 KOO23795.1 - 2.7e-07 30.1 1.4 0.022 14.0 0.1 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO23795.1 - 8.5e-06 25.7 2.6 2.2 8.4 0.1 5.4 6 0 0 6 6 5 2 Fis1 C-terminal tetratricopeptide repeat NARP1 PF12569.8 KOO23795.1 - 2.2e-05 23.6 2.1 0.076 11.9 0.0 3.4 3 1 1 4 4 4 1 NMDA receptor-regulated protein 1 TPR_21 PF09976.9 KOO23795.1 - 0.00025 20.8 2.5 0.0098 15.6 0.6 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 KOO23795.1 - 0.00054 20.2 2.8 0.0027 18.0 0.4 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat Coatomer_E PF04733.14 KOO23795.1 - 0.00085 18.8 1.4 0.11 11.9 0.0 3.3 2 1 1 3 3 3 1 Coatomer epsilon subunit TPR_MalT PF17874.1 KOO23795.1 - 0.0024 17.3 3.9 0.13 11.6 1.7 3.1 1 1 0 1 1 1 1 MalT-like TPR region FAT PF02259.23 KOO23795.1 - 0.0031 16.8 3.7 0.14 11.4 0.2 2.6 1 1 1 2 2 2 1 FAT domain DUF5113 PF17140.4 KOO23795.1 - 0.0043 16.9 3.0 0.84 9.4 0.7 4.1 3 1 1 4 4 4 1 Domain of unknown function (DUF5113) PPTA PF01239.22 KOO23795.1 - 0.0078 15.9 0.2 19 5.2 0.0 3.7 3 0 0 3 3 3 0 Protein prenyltransferase alpha subunit repeat BTAD PF03704.17 KOO23795.1 - 0.0087 16.5 2.1 0.69 10.3 0.0 3.5 2 2 1 4 4 4 1 Bacterial transcriptional activator domain DUF2225 PF09986.9 KOO23795.1 - 0.014 15.2 3.8 0.52 10.0 0.1 3.4 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Sel1 PF08238.12 KOO23795.1 - 0.063 14.0 0.4 7.7 7.4 0.0 3.8 3 0 0 3 3 3 0 Sel1 repeat Baculo_PEP_C PF04513.12 KOO23796.1 - 0.033 14.2 5.1 0.081 13.0 0.0 3.1 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Bcr-Abl_Oligo PF09036.10 KOO23796.1 - 0.1 12.6 1.7 0.57 10.2 0.0 3.0 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Rnk_N PF14760.6 KOO23796.1 - 5 7.7 8.6 1 9.9 2.2 3.5 3 0 0 3 3 3 0 Rnk N-terminus Glyco_hydro_31 PF01055.26 KOO23797.1 - 3e-29 102.5 10.8 2.1e-28 99.7 10.8 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 PAP_assoc PF03828.19 KOO23798.1 - 1.4e-18 66.8 0.1 2.8e-18 65.9 0.1 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 KOO23798.1 - 0.0077 16.5 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 KOO23798.1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase tRNA_Me_trans PF03054.16 KOO23799.1 - 3.2e-109 365.0 0.0 3.8e-109 364.8 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.21 KOO23799.1 - 0.0067 16.1 0.0 0.01 15.5 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 KOO23799.1 - 0.0084 15.7 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.20 KOO23799.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 PP-loop family BBL5 PF07289.11 KOO23800.1 - 7.8e-139 462.3 0.2 9.4e-139 462.1 0.2 1.0 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein Voldacs PF03517.13 KOO23800.1 - 0.00029 21.0 0.0 0.74 9.9 0.0 2.4 2 0 0 2 2 2 2 Regulator of volume decrease after cellular swelling PH_TFIIH PF08567.11 KOO23800.1 - 0.0037 17.6 0.0 1.7 9.0 0.0 2.6 2 1 0 2 2 2 2 TFIIH p62 subunit, N-terminal domain Vps36_ESCRT-II PF11605.8 KOO23800.1 - 0.0061 16.7 0.0 0.23 11.7 0.0 2.3 2 0 0 2 2 2 1 Vacuolar protein sorting protein 36 Vps36 His_Phos_1 PF00300.22 KOO23801.1 - 1.1e-21 77.4 0.1 1.4e-21 77.1 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Lipase_GDSL_3 PF14606.6 KOO23801.1 - 0.078 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family HEAT PF02985.22 KOO23801.1 - 0.16 12.3 0.2 4.9 7.7 0.1 2.8 3 0 0 3 3 3 0 HEAT repeat Peptidase_S10 PF00450.22 KOO23802.1 - 5.8e-81 273.0 0.0 8.5e-81 272.5 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase EF-hand_7 PF13499.6 KOO23802.1 - 6.1e-10 39.4 0.0 8.1e-09 35.8 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO23802.1 - 2.1e-09 36.3 0.0 0.0011 18.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO23802.1 - 2.6e-08 33.6 0.0 6.7e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO23802.1 - 8e-08 31.6 0.0 0.0019 18.0 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO23802.1 - 1e-06 27.9 0.1 0.017 14.6 0.0 2.6 2 0 0 2 2 2 2 EF hand VHL PF01847.16 KOO23803.1 - 0.00071 19.4 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 VHL beta domain RPS31 PF17067.5 KOO23804.1 - 1e-06 28.8 1.5 1.4e-06 28.4 1.5 1.3 1 1 0 1 1 1 1 Ribosomal protein S31e GPHR_N PF12537.8 KOO23804.1 - 0.079 13.1 0.1 0.093 12.8 0.1 1.3 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal Thx PF17070.5 KOO23804.1 - 0.088 12.9 6.4 0.14 12.3 6.4 1.3 1 0 0 1 1 1 0 30S ribosomal protein Thx GST_C PF00043.25 KOO23805.1 - 3.9e-11 43.0 0.0 6.7e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOO23805.1 - 2.2e-06 27.9 0.0 5.1e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOO23805.1 - 2.5e-06 27.6 0.0 4.2e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOO23805.1 - 8.3e-06 25.7 0.0 2.1e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOO23805.1 - 3.2e-05 24.2 0.0 6.7e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 KOO23805.1 - 0.0076 16.0 0.0 0.029 14.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KOO23805.1 - 0.0079 16.5 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 KOO23805.1 - 0.06 13.7 0.0 0.24 11.7 0.0 1.8 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein E1_dh PF00676.20 KOO23806.1 - 1.3e-83 280.5 0.0 1.7e-83 280.0 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 KOO23806.1 - 0.0006 19.6 0.1 0.0039 17.0 0.1 2.1 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Laminin_G_3 PF13385.6 KOO23807.1 - 5.8e-25 88.2 0.0 1.3e-24 87.0 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Kelch_6 PF13964.6 KOO23807.1 - 1.8e-20 72.5 0.7 3e-05 24.1 0.0 6.2 4 2 2 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KOO23807.1 - 2.6e-19 69.0 1.0 0.0022 17.9 0.0 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KOO23807.1 - 2.1e-17 63.0 0.1 5.5e-06 26.5 0.0 4.9 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KOO23807.1 - 6e-17 61.0 0.0 5.4e-05 22.7 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Filamin PF00630.19 KOO23807.1 - 9e-17 61.8 0.0 1.7e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat Kelch_5 PF13854.6 KOO23807.1 - 3.6e-16 58.8 2.5 0.003 17.5 0.0 5.0 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 KOO23807.1 - 5.8e-15 54.6 2.4 0.08 13.0 0.0 6.4 6 1 0 6 6 6 5 Kelch motif Invasin_D3 PF09134.10 KOO23807.1 - 0.029 14.7 0.0 0.43 10.9 0.0 2.3 2 0 0 2 2 2 0 Invasin, domain 3 PUB PF09409.10 KOO23808.1 - 1.4e-13 50.5 0.0 2.5e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 PUB domain UBX PF00789.20 KOO23808.1 - 2.2e-09 37.4 0.0 3.8e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 UBX domain ThiS PF02597.20 KOO23808.1 - 0.051 14.2 0.6 0.58 10.8 0.0 2.7 3 0 0 3 3 3 0 ThiS family Cytochrom_C1 PF02167.15 KOO23809.1 - 1.8e-71 240.3 0.0 2e-71 240.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family DUF1295 PF06966.12 KOO23810.1 - 3.3e-22 79.2 0.2 4.6e-22 78.7 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 KOO23810.1 - 0.0086 16.5 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.16 KOO23810.1 - 0.01 15.8 0.0 0.024 14.6 0.0 1.6 1 1 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 KOO23810.1 - 0.038 14.4 0.8 0.096 13.1 0.1 2.0 2 0 0 2 2 2 0 Phospholipid methyltransferase Ank_4 PF13637.6 KOO23811.1 - 6.3e-25 87.2 6.8 3.8e-07 30.5 0.1 5.8 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO23811.1 - 6.8e-24 83.6 5.7 4.8e-06 26.7 0.3 6.2 5 1 0 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO23811.1 - 7.4e-24 84.1 8.8 3.6e-11 43.5 0.3 4.8 4 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank PF00023.30 KOO23811.1 - 1e-18 66.8 11.4 0.0093 16.4 0.2 6.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 KOO23811.1 - 2.4e-18 64.3 5.6 0.012 16.0 0.1 6.9 6 0 0 6 6 6 5 Ankyrin repeat GRIP PF01465.20 KOO23811.1 - 1.2e-05 25.1 0.0 2.5e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 GRIP domain TPR_19 PF14559.6 KOO23815.1 - 8.8e-08 32.6 3.2 0.003 18.0 0.2 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23815.1 - 5.6e-06 26.1 5.6 1.1 9.5 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23815.1 - 9.5e-06 25.4 1.1 1.1 9.7 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO23815.1 - 0.00039 20.6 0.1 0.4 11.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23815.1 - 0.0008 19.0 0.0 0.54 10.0 0.0 3.9 4 0 0 4 4 4 1 TPR repeat TPR_1 PF00515.28 KOO23815.1 - 0.0019 17.9 2.2 17 5.4 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23815.1 - 0.0048 17.6 23.4 0.06 14.2 1.9 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23815.1 - 0.0068 16.4 1.9 0.65 10.2 0.1 4.2 4 1 1 5 5 5 1 Tetratricopeptide repeat DUF4919 PF16266.5 KOO23815.1 - 0.011 15.7 0.0 4.3 7.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) TPR_12 PF13424.6 KOO23815.1 - 0.7 10.2 5.0 7.7 6.9 2.4 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat Transgly_assoc PF04226.13 KOO23816.1 - 0.12 12.7 3.6 0.5 10.7 0.1 2.7 2 1 1 3 3 3 0 Transglycosylase associated protein MerR PF00376.23 KOO23817.1 - 0.18 11.6 0.1 0.55 10.0 0.0 1.8 2 0 0 2 2 2 0 MerR family regulatory protein U-box PF04564.15 KOO23819.1 - 6.7e-21 74.2 0.0 1.2e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 KOO23819.1 - 0.19 11.8 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein 40S_S4_C PF16121.5 KOO23820.1 - 0.00029 20.4 6.1 3.5 7.3 0.2 4.8 5 0 0 5 5 5 3 40S ribosomal protein S4 C-terminus DUF5026 PF16429.5 KOO23820.1 - 0.00048 20.2 0.0 3 8.0 0.0 4.1 1 1 4 5 5 5 2 Domain of unknown function (DUF5026) Dehydratase_MU PF02288.15 KOO23820.1 - 0.077 12.9 0.7 35 4.3 0.0 3.7 4 1 0 4 4 4 0 Dehydratase medium subunit TPR_10 PF13374.6 KOO23821.1 - 2.2e-84 275.3 42.9 2.3e-12 46.3 0.1 10.7 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23821.1 - 4.9e-84 276.7 56.8 1.8e-16 60.1 1.9 8.7 2 2 7 9 9 9 8 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO23821.1 - 6.4e-33 114.5 22.0 5.2e-16 59.0 6.4 3.6 1 1 2 3 3 3 3 MalT-like TPR region TPR_8 PF13181.6 KOO23821.1 - 4.3e-25 85.8 10.3 0.001 19.1 0.0 9.1 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23821.1 - 1.4e-24 84.9 14.2 0.00083 19.1 0.0 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23821.1 - 1.2e-21 75.1 24.2 0.028 14.5 0.1 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_4 PF07721.14 KOO23821.1 - 1.3e-20 71.8 48.6 0.065 13.9 1.4 11.4 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23821.1 - 1.8e-14 52.6 35.8 0.035 14.1 0.1 8.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_17 PF13431.6 KOO23821.1 - 9.6e-14 50.7 2.0 2 9.0 0.0 8.7 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23821.1 - 8e-13 47.8 17.5 0.019 14.6 0.0 8.8 9 0 0 9 9 9 4 TPR repeat TPR_16 PF13432.6 KOO23821.1 - 1.3e-12 48.1 34.1 0.071 13.8 0.5 9.2 3 2 5 8 8 8 7 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23821.1 - 2.1e-11 44.2 33.7 0.0059 17.1 0.5 7.2 6 2 1 7 7 7 4 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO23821.1 - 7.9e-10 38.8 8.4 4.6 7.6 0.0 8.6 9 0 0 9 9 9 1 Osmosensory transporter coiled coil TPR_3 PF07720.12 KOO23821.1 - 4e-09 36.3 0.0 6.5 6.9 0.0 7.7 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23821.1 - 4.6e-08 33.2 42.5 1.3 10.1 1.4 10.2 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_21 PF09976.9 KOO23821.1 - 0.00053 19.8 15.7 0.4 10.4 1.3 6.6 3 3 2 5 5 5 2 Tetratricopeptide repeat-like domain GP44 PF17510.2 KOO23821.1 - 0.003 17.8 0.0 5.2 7.4 0.0 4.4 1 1 2 5 5 5 1 Gene product 44 Sec16_C PF12931.7 KOO23821.1 - 0.016 14.9 0.1 50 3.4 0.0 4.0 1 1 3 4 4 4 0 Sec23-binding domain of Sec16 HisKA_3 PF07730.13 KOO23821.1 - 0.93 10.1 27.2 1.3 9.5 1.5 7.6 8 1 1 9 9 9 0 Histidine kinase TPR_6 PF13174.6 KOO23821.1 - 9.5 7.1 23.1 63 4.5 0.4 8.6 10 0 0 10 10 8 0 Tetratricopeptide repeat IFT43 PF15305.6 KOO23822.1 - 2e-23 83.1 8.2 2e-23 83.1 8.2 2.0 1 1 0 2 2 2 1 Intraflagellar transport protein 43 PP2C PF00481.21 KOO23823.1 - 4.2e-40 138.0 0.0 5.6e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO23823.1 - 0.00094 19.1 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Ras PF00071.22 KOO23824.1 - 1.2e-59 200.6 1.1 1.3e-59 200.4 1.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO23824.1 - 6.2e-35 120.0 0.2 1.1e-34 119.2 0.1 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO23824.1 - 7.6e-21 74.3 0.2 9.7e-21 74.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOO23824.1 - 3.1e-08 33.3 0.2 4.5e-08 32.7 0.2 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO23824.1 - 2e-06 27.8 0.0 6.1e-06 26.3 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOO23824.1 - 3.8e-06 26.6 0.3 9.7e-06 25.2 0.2 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOO23824.1 - 0.00032 20.7 1.1 0.76 9.7 0.0 2.7 1 1 1 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 KOO23824.1 - 0.00091 19.6 0.0 0.002 18.5 0.0 1.6 1 1 1 2 2 2 1 AAA ATPase domain SRPRB PF09439.10 KOO23824.1 - 0.00099 18.6 0.4 0.0038 16.7 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 KOO23824.1 - 0.014 14.9 0.1 0.062 12.8 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 KOO23824.1 - 0.015 15.6 0.1 0.078 13.3 0.1 2.0 1 1 1 2 2 2 0 AAA domain Gp-FAR-1 PF05823.12 KOO23824.1 - 0.027 14.8 0.2 0.039 14.3 0.2 1.2 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) FeoB_N PF02421.18 KOO23824.1 - 0.034 13.7 0.2 0.45 10.0 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B ABM PF03992.16 KOO23824.1 - 0.11 12.6 0.3 16 5.7 0.1 2.4 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase AAA_29 PF13555.6 KOO23824.1 - 0.14 12.0 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain EF-hand_5 PF13202.6 KOO23827.1 - 0.012 15.1 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.32 KOO23827.1 - 0.02 14.4 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 KOO23827.1 - 0.039 13.9 0.0 0.087 12.8 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Sulfotransfer_3 PF13469.6 KOO23828.1 - 0.00059 20.3 0.0 1.1 9.6 0.0 2.5 3 0 0 3 3 3 2 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO23828.1 - 0.0017 17.9 0.0 0.046 13.2 0.0 2.4 2 1 0 2 2 2 1 Sulfotransferase domain DUF2935 PF11155.8 KOO23829.1 - 0.0046 17.3 1.9 2.2 8.6 0.7 4.1 1 1 1 2 2 2 2 Domain of unknown function (DUF2935) GIT_CC PF16559.5 KOO23829.1 - 5.2 7.0 13.1 0.61 10.0 4.2 2.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor NHL PF01436.21 KOO23831.1 - 2.1e-27 93.7 0.1 7.4e-07 28.9 0.0 5.6 5 0 0 5 5 5 5 NHL repeat Arylesterase PF01731.20 KOO23831.1 - 1e-09 38.5 0.0 0.63 10.3 0.0 5.6 5 0 0 5 5 5 3 Arylesterase SGL PF08450.12 KOO23831.1 - 4.3e-05 23.2 0.0 2.4 7.7 0.0 4.0 2 1 2 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 KOO23831.1 - 0.045 13.0 0.0 4.2 6.5 0.0 2.8 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller Ldl_recept_b PF00058.17 KOO23831.1 - 0.11 13.0 0.1 44 4.7 0.0 3.9 4 0 0 4 4 4 0 Low-density lipoprotein receptor repeat class B UQ_con PF00179.26 KOO23833.1 - 5.7e-25 87.6 0.0 8.1e-25 87.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KOO23833.1 - 0.0047 16.8 0.0 0.071 13.0 0.0 2.5 2 1 0 2 2 2 1 UEV domain RWD PF05773.22 KOO23833.1 - 0.031 14.6 0.0 0.055 13.8 0.0 1.4 1 0 0 1 1 1 0 RWD domain Methyltransf_11 PF08241.12 KOO23835.1 - 9.1e-25 87.2 0.0 1.9e-24 86.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO23835.1 - 7e-21 74.7 0.0 1.3e-20 73.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO23835.1 - 3.7e-15 56.0 0.0 5.4e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO23835.1 - 5.5e-15 55.4 0.0 7.4e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 KOO23835.1 - 3.3e-13 49.8 0.0 4.6e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23835.1 - 1.1e-10 42.1 0.0 1.8e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO23835.1 - 9.7e-10 38.2 0.0 1.8e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 KOO23835.1 - 0.015 14.6 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain MetW PF07021.12 KOO23835.1 - 0.021 14.4 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.19 KOO23835.1 - 0.028 14.1 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 KOO23835.1 - 0.031 13.8 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain DREV PF05219.12 KOO23835.1 - 0.073 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase NAS PF03059.16 KOO23835.1 - 0.09 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Nicotianamine synthase protein Methyltransf_29 PF03141.16 KOO23835.1 - 0.17 10.4 0.0 0.27 9.7 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_9 PF08003.11 KOO23835.1 - 0.23 10.3 0.0 0.3 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Spore_YtfJ PF09579.10 KOO23835.1 - 0.26 11.5 0.7 0.49 10.6 0.7 1.4 1 0 0 1 1 1 0 Sporulation protein YtfJ (Spore_YtfJ) Ribosomal_L10 PF00466.20 KOO23836.1 - 2.3e-21 75.8 0.0 4.2e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 KOO23836.1 - 4.2e-18 65.1 0.3 7.2e-18 64.4 0.3 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 KOO23836.1 - 4.4e-10 40.0 6.2 4.4e-10 40.0 6.2 2.2 3 0 0 3 3 3 1 60s Acidic ribosomal protein DEC-1_N PF04625.13 KOO23836.1 - 0.74 8.8 7.9 1.2 8.1 7.9 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region WD40 PF00400.32 KOO23837.1 - 5.4e-29 99.8 10.2 5.4e-07 30.2 0.1 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO23837.1 - 1.1e-18 67.3 9.2 2.2e-08 34.3 0.4 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO23837.1 - 1e-06 28.8 0.5 0.45 10.4 0.0 3.8 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOO23837.1 - 8.2e-05 21.4 1.3 0.11 11.2 0.0 2.6 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOO23837.1 - 0.0013 17.7 5.2 0.094 11.7 1.8 3.8 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ELYS-bb PF16687.5 KOO23837.1 - 0.098 11.2 0.1 0.6 8.6 0.0 2.0 1 1 1 2 2 2 0 beta-propeller of ELYS nucleoporin IKI3 PF04762.12 KOO23837.1 - 0.15 10.0 1.0 0.42 8.5 0.5 1.9 1 1 0 1 1 1 0 IKI3 family LIFR_N PF18207.1 KOO23837.1 - 0.55 10.6 2.4 0.89 10.0 1.2 1.9 2 0 0 2 2 2 0 Leukemia inhibitory factor receptor N-terminal domain DUF3150 PF11348.8 KOO23838.1 - 0.01 15.1 2.4 0.017 14.4 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) GrpE PF01025.19 KOO23838.1 - 1 9.0 5.6 0.26 10.9 1.1 2.0 1 1 1 2 2 2 0 GrpE RNA_ligase PF09414.10 KOO23839.1 - 7.6e-14 52.3 0.0 1.2e-13 51.7 0.0 1.3 1 0 0 1 1 1 1 RNA ligase T4_Rnl2_C PF18043.1 KOO23839.1 - 6.5e-05 23.0 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 T4 RNA ligase 2 C-terminal DUF2470 PF10615.9 KOO23841.1 - 0.00011 22.7 0.0 0.87 10.3 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF2470) MotA_ExbB PF01618.16 KOO23842.1 - 0.099 12.4 0.6 0.19 11.5 0.5 1.5 1 1 1 2 2 2 0 MotA/TolQ/ExbB proton channel family FHA PF00498.26 KOO23845.1 - 5.8e-13 49.0 0.0 8.5e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO23845.1 - 1.1e-08 35.3 0.0 1.7e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-CRD PF17979.1 KOO23845.1 - 0.0072 16.4 0.0 0.012 15.7 0.0 1.4 1 1 0 1 1 1 1 Cysteine rich domain with multizinc binding regions PDZ_6 PF17820.1 KOO23846.1 - 0.0024 17.7 0.0 0.013 15.3 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KOO23846.1 - 0.004 17.5 0.0 0.0097 16.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Mito_fiss_reg PF05308.11 KOO23846.1 - 0.095 12.8 3.8 2.2 8.3 2.0 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator CAP_N PF01213.19 KOO23846.1 - 1.4 8.3 7.2 0.98 8.8 3.8 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal DUF2358 PF10184.9 KOO23847.1 - 1.5e-17 63.9 0.0 2.1e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) SnoaL_2 PF12680.7 KOO23847.1 - 5.4e-06 27.0 0.0 1e-05 26.1 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain DUF2499 PF10693.9 KOO23848.1 - 5.2e-35 119.6 4.7 9.5e-35 118.7 4.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2499) DUF3593 PF12159.8 KOO23848.1 - 6.5e-31 106.2 1.7 2.4e-30 104.4 1.7 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3593) GpcrRhopsn4 PF10192.9 KOO23848.1 - 1.8 7.9 6.2 0.13 11.6 1.1 1.7 2 0 0 2 2 2 0 Rhodopsin-like GPCR transmembrane domain EF-hand_7 PF13499.6 KOO23849.1 - 9.8e-21 74.0 2.3 1.2e-11 44.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23849.1 - 2.2e-19 67.7 3.6 6.3e-06 25.7 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO23849.1 - 2.6e-19 67.2 3.3 4.1e-05 22.8 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO23849.1 - 3.5e-17 61.0 3.1 2.5e-05 23.5 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO23849.1 - 1.5e-10 40.8 4.0 0.049 13.5 0.3 4.3 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 KOO23849.1 - 0.033 14.1 0.4 23 5.0 0.0 3.2 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO23849.1 - 0.038 14.3 0.3 8.3 6.8 0.0 3.2 2 2 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO23849.1 - 0.14 12.1 0.4 2.6 7.9 0.0 2.6 2 2 1 3 3 3 0 Caleosin related protein RhoGEF PF00621.20 KOO23850.1 - 1.2e-31 110.4 0.0 3.4e-31 108.9 0.0 1.7 2 0 0 2 2 2 1 RhoGEF domain AAA_17 PF13207.6 KOO23852.1 - 1.9e-05 25.1 0.1 0.00069 20.0 0.0 2.8 2 1 0 2 2 2 1 AAA domain ADK PF00406.22 KOO23852.1 - 0.0019 18.4 0.0 0.038 14.1 0.0 2.6 3 0 0 3 3 3 1 Adenylate kinase AAA_33 PF13671.6 KOO23852.1 - 0.068 13.3 5.4 0.077 13.2 0.2 3.4 3 1 0 3 3 3 0 AAA domain AAA_18 PF13238.6 KOO23852.1 - 0.14 12.7 0.0 0.31 11.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain O-FucT PF10250.9 KOO23853.1 - 6.4e-15 55.7 0.0 2.5e-14 53.7 0.0 1.8 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase MFS_5 PF05631.14 KOO23854.1 - 1.9e-70 237.6 9.4 9.5e-55 185.9 1.6 2.1 2 0 0 2 2 2 2 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 KOO23854.1 - 4.6e-18 65.3 21.1 5.4e-18 65.0 20.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Pyr_redox_2 PF07992.14 KOO23855.1 - 5.9e-53 180.0 3.2 8.4e-53 179.5 3.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOO23855.1 - 1.3e-23 83.4 0.1 2.5e-23 82.4 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOO23855.1 - 4.8e-16 59.1 4.2 2.9e-12 47.0 0.2 3.0 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOO23855.1 - 6.1e-09 35.4 15.3 0.0001 21.5 5.3 3.4 3 1 0 3 3 3 3 Glucose inhibited division protein A FAD_oxidored PF12831.7 KOO23855.1 - 3.8e-08 33.1 0.8 3.8e-08 33.1 0.8 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 KOO23855.1 - 1.9e-07 31.0 14.8 0.002 17.8 2.4 4.0 3 1 1 4 4 4 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOO23855.1 - 3.1e-07 30.5 5.5 0.00033 20.8 1.6 2.9 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOO23855.1 - 8.4e-07 28.5 0.2 0.01 15.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO23855.1 - 5e-06 25.9 18.8 1.6e-05 24.2 3.5 4.2 3 1 0 3 3 3 2 FAD binding domain Lycopene_cycl PF05834.12 KOO23855.1 - 4.6e-05 22.6 8.3 0.023 13.8 0.2 3.1 3 0 0 3 3 3 2 Lycopene cyclase protein HI0933_like PF03486.14 KOO23855.1 - 0.00096 18.0 11.4 0.001 17.9 1.0 3.1 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.19 KOO23855.1 - 0.0011 18.4 5.8 0.068 12.4 0.6 2.4 2 0 0 2 2 2 2 FAD binding domain AlaDh_PNT_C PF01262.21 KOO23855.1 - 0.0024 17.2 7.2 0.098 11.9 0.5 2.6 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 KOO23855.1 - 0.0039 17.6 1.9 0.023 15.2 0.2 2.3 2 0 0 2 2 2 1 Putative NAD(P)-binding Thi4 PF01946.17 KOO23855.1 - 0.0041 16.4 4.4 0.0084 15.4 0.7 2.3 2 0 0 2 2 2 1 Thi4 family TrkA_N PF02254.18 KOO23855.1 - 0.016 15.4 1.0 0.22 11.8 0.1 2.7 2 1 0 2 2 2 0 TrkA-N domain K_oxygenase PF13434.6 KOO23855.1 - 0.017 14.3 0.6 0.1 11.7 0.0 2.2 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) XdhC_C PF13478.6 KOO23855.1 - 0.054 14.0 0.3 1 9.9 0.1 2.5 2 0 0 2 2 2 0 XdhC Rossmann domain F420_oxidored PF03807.17 KOO23855.1 - 3.9 8.1 13.0 2.4 8.8 0.1 3.8 4 0 0 4 4 3 0 NADP oxidoreductase coenzyme F420-dependent DFP PF04127.15 KOO23855.1 - 5.2 6.9 6.1 25 4.6 0.0 3.1 2 1 1 3 3 3 0 DNA / pantothenate metabolism flavoprotein 3HCDH_N PF02737.18 KOO23855.1 - 6.2 6.7 11.7 1.7 8.5 0.1 3.2 3 1 1 4 4 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PP2C PF00481.21 KOO23856.1 - 2.4e-40 138.8 0.0 3.5e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO23856.1 - 2.4e-07 30.6 0.2 4.8e-07 29.6 0.2 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C DUF3464 PF11947.8 KOO23857.1 - 1.3e-32 112.7 0.0 2.1e-32 111.9 0.0 1.4 1 0 0 1 1 1 1 Photosynthesis affected mutant 68 PDZ PF00595.24 KOO23857.1 - 1.1e-06 28.9 0.1 2.5e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO23857.1 - 1.3e-05 24.9 0.1 0.00034 20.4 0.0 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO23857.1 - 8.9e-05 22.7 0.6 0.00032 20.9 0.1 2.1 3 0 0 3 3 3 1 PDZ domain Oxidored_q6 PF01058.22 KOO23858.1 - 3.3e-23 81.9 0.0 3.9e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Secapin PF17521.2 KOO23858.1 - 0.1 12.4 0.3 0.1 12.4 0.3 2.2 1 1 1 2 2 2 0 Honey bee peptides Ion_trans_2 PF07885.16 KOO23859.1 - 5.1e-14 52.0 2.1 5.1e-14 52.0 2.1 2.1 2 0 0 2 2 2 1 Ion channel WD40 PF00400.32 KOO23860.1 - 1.1e-13 51.3 20.3 0.00023 21.9 0.2 7.7 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO23860.1 - 1.1e-10 41.6 6.6 0.00066 19.9 0.1 6.2 3 2 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 KOO23860.1 - 0.0031 15.6 0.6 2 6.3 0.1 3.0 3 0 0 3 3 3 2 IKI3 family eIF2A PF08662.11 KOO23860.1 - 0.006 16.5 0.1 0.12 12.3 0.0 3.0 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOO23860.1 - 0.0067 15.4 1.8 0.78 8.6 0.0 3.0 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 KOO23860.1 - 0.012 14.7 1.9 0.52 9.3 0.2 3.5 3 1 0 3 3 3 0 Coatomer WD associated region Atg14 PF10186.9 KOO23861.1 - 0.04 13.0 21.0 0.5 9.4 3.0 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 NPV_P10 PF05531.12 KOO23861.1 - 0.24 11.9 2.1 2.9 8.4 0.3 2.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 KOO23861.1 - 0.58 10.2 5.4 1.3 9.1 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 KOO23861.1 - 0.79 10.1 9.5 4 7.8 0.1 3.4 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4407 PF14362.6 KOO23861.1 - 1.9 7.8 27.5 0.74 9.1 21.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) GAS PF13851.6 KOO23861.1 - 1.9 7.8 23.7 0.83 9.0 3.8 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Fzo_mitofusin PF04799.13 KOO23861.1 - 3.2 7.3 8.9 1.7 8.2 0.1 2.7 3 0 0 3 3 3 0 fzo-like conserved region Lectin_N PF03954.14 KOO23861.1 - 5.7 6.7 9.6 5.9 6.7 1.9 3.2 2 2 0 2 2 2 0 Hepatic lectin, N-terminal domain PRKG1_interact PF15898.5 KOO23861.1 - 9.9 7.1 23.1 8.4 7.4 0.5 3.2 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain EMP70 PF02990.16 KOO23863.1 - 9.4e-192 638.3 9.6 5.1e-187 622.7 7.0 2.4 2 1 1 3 3 3 2 Endomembrane protein 70 Phage_holin_3_6 PF07332.11 KOO23863.1 - 7.9 6.6 0.0 3.7 7.6 6.0 5.2 4 1 1 5 5 5 0 Putative Actinobacterial Holin-X, holin superfamily III Thaumatin PF00314.17 KOO23864.1 - 1.5e-21 77.0 1.3 3.4e-21 75.9 1.3 1.6 1 1 0 1 1 1 1 Thaumatin family TPR_10 PF13374.6 KOO23866.1 - 1.9e-17 62.5 0.4 6.8e-09 35.3 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23866.1 - 7.2e-17 61.5 4.6 4e-10 39.9 1.1 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23866.1 - 2.6e-07 30.2 1.2 0.002 18.1 0.5 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23866.1 - 2.6e-06 27.0 0.4 0.082 12.8 0.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23866.1 - 1e-05 26.1 1.4 2e-05 25.1 1.4 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO23866.1 - 0.00016 21.2 0.4 0.0088 15.5 0.2 1.9 1 1 1 2 2 2 1 MalT-like TPR region TPR_7 PF13176.6 KOO23866.1 - 0.00019 21.2 0.1 0.51 10.5 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23866.1 - 0.00028 20.9 1.9 0.25 11.6 0.1 2.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23866.1 - 0.00033 21.2 0.6 0.22 12.4 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23866.1 - 0.0006 20.3 0.4 0.0012 19.3 0.4 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_3 PF07720.12 KOO23866.1 - 0.0037 17.2 0.1 0.46 10.5 0.0 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO23866.1 - 0.0039 17.5 0.7 0.53 10.8 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO23866.1 - 0.09 13.5 1.7 6.4 7.7 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23866.1 - 0.11 12.2 0.1 2.3 8.0 0.0 2.2 2 0 0 2 2 2 0 TPR repeat AOX PF01786.17 KOO23867.1 - 1.4e-67 227.4 0.1 1.7e-67 227.1 0.1 1.1 1 0 0 1 1 1 1 Alternative oxidase Methyltransf_21 PF05050.12 KOO23868.1 - 1.8e-09 37.9 0.0 2e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain UPF0223 PF05256.12 KOO23869.1 - 0.082 13.3 1.0 0.13 12.6 0.1 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0223) Pkinase PF00069.25 KOO23870.1 - 1.2e-58 198.5 0.0 1.5e-58 198.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO23870.1 - 5.4e-32 111.1 0.0 6.7e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO23870.1 - 4.1e-11 42.7 0.0 2.3e-08 33.7 0.0 2.1 2 0 0 2 2 2 2 Kinase-like AAA_8 PF12780.7 KOO23870.1 - 0.15 11.4 0.7 0.22 10.8 0.7 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 Thioredoxin PF00085.20 KOO23871.1 - 0.0012 18.8 0.0 0.0012 18.8 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Amino_oxidase PF01593.24 KOO23872.1 - 5.9e-32 111.5 0.0 7.6e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase GILT PF03227.16 KOO23873.1 - 2.2e-13 50.4 1.1 3.9e-13 49.6 1.1 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) RST PF12174.8 KOO23875.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain RR_TM4-6 PF06459.12 KOO23876.1 - 0.024 14.5 7.8 0.027 14.3 7.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 UPF0242 PF06785.11 KOO23876.1 - 0.61 10.2 15.1 0.75 9.9 15.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF724 PF05266.14 KOO23876.1 - 1 9.2 16.6 1.4 8.7 16.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) AAA_11 PF13086.6 KOO23876.1 - 4.3 7.0 12.4 5.4 6.7 12.4 1.1 1 0 0 1 1 1 0 AAA domain Vfa1 PF08432.10 KOO23876.1 - 5.8 7.2 14.4 7.4 6.9 14.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Methyltransf_21 PF05050.12 KOO23877.1 - 5.8e-11 42.7 0.0 1.4e-10 41.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase FkbM domain LRR_6 PF13516.6 KOO23879.1 - 1.2e-28 96.7 8.5 8.5e-06 25.4 0.1 7.6 8 0 0 8 8 8 6 Leucine Rich repeat LRR_1 PF00560.33 KOO23879.1 - 3.8e-06 26.7 0.1 29 5.8 0.0 6.0 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO23879.1 - 7.8e-05 22.4 2.6 0.62 9.9 0.0 5.0 4 1 1 5 5 5 1 Leucine rich repeat LRR_4 PF12799.7 KOO23879.1 - 0.00045 20.5 0.1 3.5 8.2 0.0 4.3 5 0 0 5 5 5 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO23880.1 - 1.1e-16 60.3 25.7 6.4e-09 35.4 4.4 9.0 7 2 3 10 10 10 4 Leucine rich repeat LRR_4 PF12799.7 KOO23880.1 - 1.5e-15 57.1 32.7 0.0016 18.8 0.5 10.9 10 2 3 13 13 13 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO23880.1 - 5e-13 48.0 48.5 0.0052 16.7 0.0 15.9 18 0 0 18 18 18 7 Leucine Rich repeat SH3_3 PF08239.11 KOO23880.1 - 0.0014 18.9 0.1 0.0042 17.3 0.1 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain LRR_1 PF00560.33 KOO23880.1 - 0.059 13.9 19.1 9.8 7.2 0.0 10.2 12 1 0 12 12 12 0 Leucine Rich Repeat DUF4033 PF13225.6 KOO23881.1 - 0.23 11.5 2.8 1 9.4 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4033) Fer4_3 PF12798.7 KOO23881.1 - 3.3 8.9 11.0 5.9 8.1 2.8 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain PTS_2-RNA PF01885.16 KOO23883.1 - 3.4e-31 108.7 0.0 8.1e-31 107.5 0.0 1.7 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family NACHT PF05729.12 KOO23883.1 - 1.8e-05 24.7 0.1 7.7e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 NACHT domain TPR_MLP1_2 PF07926.12 KOO23883.1 - 0.0035 17.4 3.4 0.0035 17.4 3.4 4.3 3 1 1 4 4 4 1 TPR/MLP1/MLP2-like protein LRR_6 PF13516.6 KOO23883.1 - 0.038 14.0 0.0 1 9.6 0.0 2.9 3 0 0 3 3 3 0 Leucine Rich repeat Ricin_B_lectin PF00652.22 KOO23884.1 - 2.4e-22 79.5 6.3 4.3e-22 78.7 6.3 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 KOO23884.1 - 6.1e-11 42.9 7.7 3.4e-05 24.5 1.3 2.8 2 1 2 4 4 4 3 Ricin-type beta-trefoil lectin domain-like CDtoxinA PF03498.14 KOO23884.1 - 0.0018 17.9 0.2 0.26 10.9 0.0 2.3 1 1 1 2 2 2 2 Cytolethal distending toxin A/C domain LRR_8 PF13855.6 KOO23885.1 - 3.6e-07 29.8 0.1 9.2e-07 28.5 0.1 1.7 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KOO23885.1 - 3.5e-05 24.1 1.0 9.7e-05 22.7 0.0 2.3 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LtrA PF06772.11 KOO23886.1 - 2.2e-12 46.9 2.3 5.1e-12 45.7 2.3 1.6 1 1 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) Tricorn_PDZ PF14685.6 KOO23887.1 - 0.057 13.4 0.4 1.4 8.9 0.1 3.1 3 0 0 3 3 3 0 Tricorn protease PDZ domain MFS_1 PF07690.16 KOO23888.1 - 1e-12 47.7 31.0 1e-12 47.7 31.0 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily PKD_channel PF08016.12 KOO23889.1 - 2.8e-61 207.5 0.0 4e-61 207.0 0.0 1.2 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 KOO23889.1 - 4.2e-06 26.2 10.9 4.2e-06 26.2 10.9 1.7 2 0 0 2 2 2 1 Ion transport protein eIF2_C PF09173.11 KOO23890.1 - 3e-36 123.5 0.3 9.3e-36 122.0 0.3 1.9 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 KOO23890.1 - 4.7e-23 81.7 1.9 3.2e-22 79.0 1.9 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KOO23890.1 - 2.4e-11 43.8 0.4 5.8e-11 42.6 0.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 KOO23890.1 - 0.0019 18.1 0.2 0.02 14.8 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 KOO23890.1 - 0.0047 17.0 0.0 0.012 15.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOO23890.1 - 0.07 13.2 0.1 0.62 10.1 0.1 2.2 1 1 1 2 2 2 0 Dynamin family MMR_HSR1_Xtn PF16897.5 KOO23890.1 - 0.1 12.6 0.1 0.27 11.2 0.1 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Ribosomal_S3Ae PF01015.18 KOO23891.1 - 3.6e-87 291.2 1.5 4.4e-87 290.9 1.5 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Phage_TAC_5 PF08890.11 KOO23891.1 - 0.026 14.5 0.4 0.28 11.2 0.0 2.5 1 1 2 3 3 3 0 Phage XkdN-like tail assembly chaperone protein, TAC MRP-L27 PF09809.9 KOO23891.1 - 0.043 13.7 0.1 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 Clat_adaptor_s PF01217.20 KOO23891.1 - 0.15 12.0 0.5 1.5 8.7 0.1 2.1 2 0 0 2 2 2 0 Clathrin adaptor complex small chain SRP19 PF01922.17 KOO23892.1 - 1.1e-21 77.5 0.0 1.9e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein Asp_protease_2 PF13650.6 KOO23892.1 - 8.6e-05 23.1 0.0 0.13 12.9 0.0 2.5 2 0 0 2 2 2 2 Aspartyl protease Asp PF00026.23 KOO23892.1 - 0.042 13.3 0.0 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 Eukaryotic aspartyl protease FLgD_tudor PF13861.6 KOO23892.1 - 0.045 14.0 0.0 0.23 11.7 0.0 2.3 3 0 0 3 3 3 0 FlgD Tudor-like domain gag-asp_proteas PF13975.6 KOO23892.1 - 0.079 13.5 0.0 4.7 7.8 0.0 2.4 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease tRNA_Me_trans PF03054.16 KOO23894.1 - 1.3e-99 333.4 0.0 1.4e-99 333.2 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase GARS_A PF01071.19 KOO23895.1 - 9.5e-73 244.1 0.0 1.3e-72 243.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 KOO23895.1 - 1e-28 99.9 0.3 3.1e-28 98.4 0.3 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 KOO23895.1 - 4.5e-25 87.8 4.8 5.7e-25 87.4 3.3 2.0 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain CPSase_L_D2 PF02786.17 KOO23895.1 - 1.2e-06 28.2 0.0 2.3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 KOO23895.1 - 1.3e-05 24.8 0.0 2.6e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 KOO23895.1 - 3.2e-05 24.1 0.0 6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 KOO23895.1 - 0.004 16.8 0.0 0.0081 15.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 KOO23895.1 - 0.02 14.4 0.0 0.047 13.1 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_2 PF08442.10 KOO23895.1 - 0.021 14.4 0.2 0.16 11.5 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain Dpy-30 PF05186.13 KOO23895.1 - 0.05 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Dpy-30 motif ATPgrasp_ST PF14397.6 KOO23895.1 - 0.075 12.3 0.0 1.1 8.4 0.0 2.3 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Dala_Dala_lig_C PF07478.13 KOO23895.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 KOO23896.1 - 2.3e-08 34.2 0.0 6.1e-08 32.9 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain PGM1_C PF18105.1 KOO23896.1 - 0.0053 16.3 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 PGM1 C-terminal domain ShK PF01549.24 KOO23898.1 - 3.7e-07 30.6 6.6 3.7e-07 30.6 6.6 3.9 3 0 0 3 3 3 2 ShK domain-like Phytochelatin PF05023.14 KOO23898.1 - 0.072 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Phytochelatin synthase FA_desaturase PF00487.24 KOO23899.1 - 2e-31 109.8 23.8 2e-31 109.8 23.8 2.0 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 KOO23899.1 - 1.6e-06 28.2 0.0 3.1e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DEAD PF00270.29 KOO23900.1 - 7.6e-47 159.3 0.0 1e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO23900.1 - 0.037 14.0 0.0 0.058 13.4 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TetR_C_15 PF17918.1 KOO23900.1 - 0.6 10.9 6.3 3.9 8.3 1.4 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Kelch_4 PF13418.6 KOO23901.1 - 7.6e-31 105.9 3.1 1.2e-05 25.2 0.1 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain BTB PF00651.31 KOO23901.1 - 3.8e-29 101.2 0.2 1.7e-28 99.0 0.1 2.0 1 1 1 2 2 2 1 BTB/POZ domain Kelch_5 PF13854.6 KOO23901.1 - 7e-26 89.7 0.0 0.002 18.1 0.0 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.15 KOO23901.1 - 7.5e-23 79.6 0.1 0.00061 19.7 0.0 5.8 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KOO23901.1 - 7.6e-21 73.6 0.7 1.2e-05 25.5 0.0 5.6 3 2 2 5 5 5 4 Kelch motif Kelch_1 PF01344.25 KOO23901.1 - 1.3e-20 72.7 0.1 0.00034 20.1 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KOO23901.1 - 7.9e-19 67.5 18.4 4.1e-05 23.7 0.0 6.5 8 1 0 8 8 8 4 Galactose oxidase, central domain BACK PF07707.15 KOO23901.1 - 0.00011 22.3 0.1 0.00051 20.1 0.0 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Flagellin_C PF00700.21 KOO23902.1 - 0.0012 19.1 7.8 0.0024 18.2 7.8 1.4 1 0 0 1 1 1 1 Bacterial flagellin C-terminal helical region IQ PF00612.27 KOO23902.1 - 0.035 13.9 0.3 0.079 12.8 0.3 1.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif Atg14 PF10186.9 KOO23902.1 - 0.19 10.8 1.4 0.28 10.3 1.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sugar_tr PF00083.24 KOO23903.1 - 3.1e-33 115.3 6.5 4e-33 115.0 6.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO23903.1 - 1.6e-15 56.9 16.5 1.8e-15 56.7 16.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 KOO23903.1 - 0.00053 18.9 4.1 0.00077 18.4 4.1 1.1 1 0 0 1 1 1 1 MFS_1 like family TPT PF03151.16 KOO23904.1 - 1.6e-09 37.6 7.2 3.5e-09 36.4 7.2 1.5 1 1 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 KOO23904.1 - 8.3e-07 28.5 7.7 1.2e-06 27.9 7.7 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO23904.1 - 2.2e-05 24.7 22.5 0.0011 19.2 4.7 2.9 2 1 0 2 2 2 2 EamA-like transporter family Helicase_C PF00271.31 KOO23905.1 - 4.3e-28 97.9 0.0 5.2e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.6 KOO23905.1 - 0.0066 16.6 0.0 0.0091 16.2 0.0 1.1 1 0 0 1 1 1 1 Helicase C-terminal domain ERCC3_RAD25_C PF16203.5 KOO23905.1 - 0.044 13.0 0.0 0.055 12.7 0.0 1.1 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CitMHS PF03600.16 KOO23906.1 - 0.0022 17.3 1.0 0.0022 17.3 1.0 1.6 2 0 0 2 2 2 1 Citrate transporter Astacin PF01400.24 KOO23907.1 - 4.9e-29 101.3 0.2 7e-29 100.8 0.2 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Metallopep PF12044.8 KOO23907.1 - 0.0011 17.7 0.1 0.0016 17.2 0.1 1.2 1 0 0 1 1 1 1 Putative peptidase family Peptidase_M66 PF10462.9 KOO23907.1 - 0.0084 15.1 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_3 PF13582.6 KOO23907.1 - 0.011 16.3 0.1 0.02 15.4 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like PRIMA1 PF16101.5 KOO23907.1 - 0.016 15.2 3.6 0.016 15.2 3.6 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Peptidase_M10 PF00413.24 KOO23907.1 - 0.017 15.0 0.3 0.029 14.2 0.3 1.5 1 1 0 1 1 1 0 Matrixin Reprolysin_5 PF13688.6 KOO23907.1 - 0.068 13.3 0.4 0.11 12.6 0.4 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 KOO23907.1 - 0.072 12.7 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like ArAE_2_N PF10337.9 KOO23908.1 - 0.56 9.2 5.0 0.065 12.3 0.2 1.8 2 0 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal DnaJ PF00226.31 KOO23909.1 - 6.3e-17 61.5 0.5 1.2e-16 60.6 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain Ank_2 PF12796.7 KOO23909.1 - 1.3e-06 28.9 0.0 3.6e-06 27.5 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO23909.1 - 1.4e-05 25.1 0.0 0.019 15.4 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 KOO23909.1 - 2.2e-05 24.9 0.0 8.2e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO23909.1 - 8.2e-05 22.8 0.0 0.0053 17.1 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO23909.1 - 0.02 15.3 0.0 0.65 10.5 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeat LRR_6 PF13516.6 KOO23910.1 - 1.3e-09 37.3 2.8 0.072 13.2 0.1 3.9 3 0 0 3 3 3 3 Leucine Rich repeat LRR_8 PF13855.6 KOO23910.1 - 0.0027 17.4 0.6 0.89 9.4 0.1 3.2 2 1 0 2 2 2 2 Leucine rich repeat DUF677 PF05055.12 KOO23910.1 - 0.029 13.3 1.1 0.056 12.3 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF677) LRR_4 PF12799.7 KOO23910.1 - 0.036 14.5 0.0 4 8.0 0.0 2.7 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) DUF179 PF02622.15 KOO23911.1 - 5.9e-19 68.6 0.0 1.3e-18 67.5 0.0 1.5 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 Chromo PF00385.24 KOO23911.1 - 0.0013 18.6 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RabGAP-TBC PF00566.18 KOO23912.1 - 6.5e-22 78.3 0.0 7.7e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Peptidase_C1 PF00112.23 KOO23913.1 - 2.5e-56 191.2 0.8 3.5e-56 190.7 0.8 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KOO23913.1 - 9.1e-09 35.6 0.1 1.9e-08 34.6 0.1 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KOO23913.1 - 1.1e-05 24.4 0.1 0.00038 19.4 0.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Proton_antipo_M PF00361.20 KOO23913.1 - 0.084 12.1 2.1 0.14 11.3 2.1 1.2 1 0 0 1 1 1 0 Proton-conducting membrane transporter SAP PF02037.27 KOO23914.1 - 4.5e-05 23.1 0.1 0.0001 21.9 0.1 1.6 1 0 0 1 1 1 1 SAP domain Ion_trans PF00520.31 KOO23915.1 - 6.2e-194 641.3 61.7 3.9e-60 203.1 5.5 4.5 4 1 0 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO23915.1 - 0.00026 20.7 0.0 0.00074 19.2 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated DUF4598 PF15370.6 KOO23915.1 - 0.45 11.0 1.6 1 9.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) TTL PF03133.15 KOO23916.1 - 5.2e-30 104.6 0.0 3.8e-24 85.3 0.0 2.1 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 KOO23916.1 - 0.00021 20.7 0.0 0.28 10.4 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 KOO23916.1 - 0.0024 17.9 0.0 2.8 8.0 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_YheCD PF14398.6 KOO23916.1 - 0.0037 16.6 0.0 1.2 8.3 0.0 2.8 2 1 0 2 2 2 2 YheC/D like ATP-grasp YrhK PF14145.6 KOO23921.1 - 0.00012 21.8 34.0 0.06 13.2 4.0 6.3 4 2 2 6 6 6 5 YrhK-like protein Ion_trans PF00520.31 KOO23922.1 - 5.1e-193 638.3 65.5 4.8e-56 189.7 6.7 4.0 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO23922.1 - 1e-05 25.2 0.0 2.4e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO23922.1 - 1.9e-05 23.5 4.6 1.9e-05 23.5 4.6 9.5 8 3 3 11 11 11 6 Polycystin cation channel Methyltransf_PK PF05891.12 KOO23923.1 - 2.8e-60 203.6 0.0 4.5e-60 202.9 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Ank_2 PF12796.7 KOO23923.1 - 2.8e-16 59.9 0.1 1e-08 35.7 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO23923.1 - 4.3e-16 58.8 0.1 6.2e-07 29.6 0.0 3.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO23923.1 - 2.3e-13 50.3 0.5 5e-07 30.1 0.0 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Methyltransf_25 PF13649.6 KOO23923.1 - 7.2e-13 49.1 0.0 8.6e-06 26.4 0.0 3.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 KOO23923.1 - 1.2e-11 45.1 0.0 6.6e-06 26.7 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain Ank_3 PF13606.6 KOO23923.1 - 1.9e-09 37.0 0.1 0.42 11.3 0.0 5.0 5 0 0 5 5 4 3 Ankyrin repeat Ank PF00023.30 KOO23923.1 - 2e-08 34.3 0.5 0.68 10.5 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Methyltransf_2 PF00891.18 KOO23923.1 - 0.00011 21.6 0.0 0.002 17.5 0.0 2.8 3 0 0 3 3 3 1 O-methyltransferase domain Methyltransf_23 PF13489.6 KOO23923.1 - 0.001 18.9 0.0 0.047 13.5 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23923.1 - 0.0034 18.1 0.0 0.089 13.5 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOO23923.1 - 0.013 15.1 0.1 0.45 10.1 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_24 PF13578.6 KOO23923.1 - 0.02 15.9 0.4 0.61 11.1 0.0 3.5 2 1 1 3 3 3 0 Methyltransferase domain Bin3 PF06859.12 KOO23923.1 - 0.042 14.5 0.6 0.34 11.6 0.0 2.6 3 0 0 3 3 3 0 Bicoid-interacting protein 3 (Bin3) FapA PF03961.13 KOO23923.1 - 1.7 7.2 3.8 2.5 6.6 3.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PLAC8 PF04749.17 KOO23924.1 - 1.7e-12 48.2 6.6 5e-11 43.5 6.6 2.1 1 1 0 1 1 1 1 PLAC8 family CcmH PF03918.14 KOO23924.1 - 0.24 10.7 3.0 2.4 7.4 0.0 2.5 3 0 0 3 3 3 0 Cytochrome C biogenesis protein RseC_MucC PF04246.12 KOO23924.1 - 1.5 8.8 5.6 0.45 10.5 1.6 2.0 2 1 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Antimicrobial_5 PF08026.11 KOO23925.1 - 0.77 9.9 5.8 4.6 7.4 1.8 2.5 2 0 0 2 2 2 0 Bee antimicrobial peptide Sel1 PF08238.12 KOO23926.1 - 6.8e-68 223.6 73.2 4.8e-08 33.4 1.6 11.0 11 0 0 11 11 11 10 Sel1 repeat MOFRL PF05161.13 KOO23926.1 - 0.00089 19.4 29.2 0.0088 16.2 0.3 5.7 1 1 9 10 10 10 7 MOFRL family Blt1_C PF17183.4 KOO23926.1 - 0.02 14.5 6.1 3.6e+02 0.8 0.0 8.1 11 0 0 11 11 11 0 Get5 carboxyl domain TPR_10 PF13374.6 KOO23926.1 - 0.21 11.5 22.6 3.4 7.6 0.0 8.8 8 0 0 8 8 8 0 Tetratricopeptide repeat Peptidase_M18 PF02127.15 KOO23927.1 - 1.8e-144 481.7 0.0 7.3e-81 272.1 0.0 2.0 2 0 0 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 KOO23927.1 - 2.2e-06 26.9 0.0 0.00094 18.3 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase WD40 PF00400.32 KOO23928.1 - 3.5e-37 125.7 37.2 3.2e-06 27.8 0.0 11.3 13 0 0 13 13 13 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO23928.1 - 1.4e-15 57.3 2.5 6.5e-05 23.2 0.2 6.4 4 3 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOO23928.1 - 1.7e-07 30.3 0.4 0.0036 16.0 0.0 3.7 3 1 1 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOO23928.1 - 1e-06 28.0 0.2 0.032 13.2 0.0 4.2 4 1 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 KOO23928.1 - 5.2e-06 26.2 2.6 0.0015 18.1 0.2 3.5 2 2 0 3 3 3 1 PQQ-like domain WD40_like PF17005.5 KOO23928.1 - 6.1e-05 22.5 0.1 0.1 11.9 0.0 3.7 3 2 1 4 4 4 2 WD40-like domain PQQ_3 PF13570.6 KOO23928.1 - 0.0061 17.0 13.9 20 5.8 0.2 8.6 9 1 0 9 9 9 0 PQQ-like domain Cytochrom_D1 PF02239.16 KOO23928.1 - 0.021 13.3 0.6 2.7 6.4 0.2 3.5 3 0 0 3 3 3 0 Cytochrome D1 heme domain Hira PF07569.11 KOO23928.1 - 0.094 12.4 0.1 97 2.6 0.0 4.0 4 1 1 5 5 5 0 TUP1-like enhancer of split Nucleotid_trans PF03407.16 KOO23929.1 - 3.1e-31 109.0 0.0 5.5e-31 108.2 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase PDZ PF00595.24 KOO23930.1 - 0.023 15.0 0.0 0.035 14.4 0.0 1.3 1 0 0 1 1 1 0 PDZ domain Methyltransf_24 PF13578.6 KOO23931.1 - 3.3e-08 34.5 0.4 7.2e-08 33.4 0.2 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ion_trans PF00520.31 KOO23932.1 - 1.6e-23 83.3 1.7 3.6e-23 82.1 1.7 1.6 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO23932.1 - 0.018 15.0 1.9 0.046 13.7 1.9 1.7 1 0 0 1 1 1 0 Ion channel DUF1664 PF07889.12 KOO23932.1 - 0.34 10.9 1.6 0.82 9.7 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) His_Phos_1 PF00300.22 KOO23933.1 - 1.2e-24 87.1 0.0 1.4e-23 83.6 0.0 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Zeta_toxin PF06414.12 KOO23933.1 - 2e-12 46.8 0.0 1.5e-11 44.0 0.0 2.0 1 1 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 KOO23933.1 - 5.8e-07 29.8 0.0 1.2e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOO23933.1 - 0.0021 18.5 0.0 0.0063 16.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO23933.1 - 0.14 12.4 0.0 0.42 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 KOO23933.1 - 0.14 11.9 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF3421 PF11901.8 KOO23935.1 - 1.3e-10 41.2 0.1 0.036 14.1 0.0 4.6 4 0 0 4 4 4 3 Protein of unknown function (DUF3421) Cupin_3 PF05899.12 KOO23935.1 - 0.0034 17.0 0.1 0.07 12.8 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Synaptobrevin PF00957.21 KOO23935.1 - 0.023 14.5 0.4 0.039 13.8 0.4 1.2 1 0 0 1 1 1 0 Synaptobrevin LPD23 PF18838.1 KOO23935.1 - 0.024 14.4 0.2 14 5.6 0.0 3.1 2 0 0 2 2 2 0 Large polyvalent protein associated domain 23 PhoR PF11808.8 KOO23935.1 - 0.036 14.5 0.8 13 6.3 0.1 2.5 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR EF-hand_1 PF00036.32 KOO23936.1 - 1.6e-33 111.7 11.0 4.3e-09 35.3 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO23936.1 - 9.3e-30 102.9 8.5 1.5e-16 60.6 0.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23936.1 - 9.7e-26 87.5 9.6 2.5e-09 36.3 0.0 4.9 4 2 2 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 KOO23936.1 - 1.1e-25 89.2 11.0 5.3e-12 45.4 0.3 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO23936.1 - 3.5e-20 70.5 8.5 2e-06 27.0 0.2 4.8 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.6 KOO23936.1 - 5.6e-14 52.2 0.2 7.6e-08 32.6 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO23936.1 - 2.5e-06 27.4 4.0 0.19 11.7 0.8 3.6 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand SurA_N_3 PF13624.6 KOO23936.1 - 0.00011 22.0 0.8 0.4 10.4 0.1 2.1 1 1 0 2 2 2 2 SurA N-terminal domain Caleosin PF05042.13 KOO23936.1 - 0.00041 20.3 1.0 3.5 7.5 0.0 3.7 1 1 3 4 4 4 1 Caleosin related protein SurA_N_2 PF13623.6 KOO23936.1 - 0.0008 19.3 0.7 0.73 9.7 0.0 2.3 1 1 1 2 2 2 2 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KOO23936.1 - 0.0021 18.4 0.4 1.3 9.4 0.2 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO23936.1 - 0.0037 17.6 0.7 1.5 9.2 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain SUB1_ProdP9 PF18213.1 KOO23936.1 - 0.011 15.5 1.3 0.024 14.5 0.4 1.9 1 1 1 2 2 2 0 SUB1 protease Prodomain ProdP9 DUF3008 PF11450.8 KOO23936.1 - 0.023 14.8 0.2 0.023 14.8 0.2 3.0 4 0 0 4 4 3 0 Protein of unknwon function (DUF3008) LETM1 PF07766.13 KOO23936.1 - 0.042 13.2 0.8 0.13 11.6 0.7 1.9 1 1 1 2 2 2 0 LETM1-like protein YolD PF08863.10 KOO23936.1 - 0.07 13.2 1.7 3.2 7.9 0.1 2.8 3 1 0 3 3 3 0 YolD-like protein Peptidase_M24 PF00557.24 KOO23936.1 - 0.079 12.6 0.2 1.7 8.3 0.0 2.4 2 1 1 3 3 3 0 Metallopeptidase family M24 PMBR PF09373.10 KOO23936.1 - 0.1 12.8 0.2 22 5.4 0.0 4.4 6 0 0 6 6 6 0 Pseudomurein-binding repeat Acetyltransf_11 PF13720.6 KOO23936.1 - 0.13 12.7 0.4 1.1 9.8 0.1 2.4 1 1 1 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF3911 PF13050.6 KOO23936.1 - 0.16 12.1 1.5 0.6 10.3 0.5 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3911) DUF3486 PF11985.8 KOO23936.1 - 0.24 11.8 1.7 5.1 7.5 0.1 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3486) SapB_1 PF05184.15 KOO23936.1 - 1.1 9.3 5.9 3.2 7.9 0.2 2.7 3 0 0 3 3 2 0 Saposin-like type B, region 1 EF-hand_7 PF13499.6 KOO23937.1 - 0.12 12.9 1.4 0.55 10.7 0.1 2.8 3 1 0 3 3 3 0 EF-hand domain pair MCD_N PF17408.2 KOO23937.1 - 2.8 8.1 6.3 0.65 10.2 0.5 3.0 3 1 0 3 3 3 0 Malonyl-CoA decarboxylase N-terminal domain EF-hand_7 PF13499.6 KOO23938.1 - 4.1e-06 27.2 0.1 9.8e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO23938.1 - 1.6e-05 24.4 0.7 0.0026 17.5 0.1 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO23938.1 - 0.00023 20.5 0.1 0.0058 16.1 0.0 2.4 2 0 0 2 2 2 1 EF hand Methyltransf_25 PF13649.6 KOO23939.1 - 1.5e-23 83.3 0.0 2.7e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO23939.1 - 5.7e-22 78.2 0.0 9.7e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO23939.1 - 2.1e-18 66.6 0.0 2.7e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO23939.1 - 6.1e-18 65.0 0.0 1.8e-16 60.2 0.0 2.0 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KOO23939.1 - 6.4e-13 48.9 0.0 1.4e-12 47.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO23939.1 - 2.2e-11 44.3 0.0 3.4e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO23939.1 - 2.6e-07 30.3 0.0 4e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.20 KOO23939.1 - 4.6e-05 22.6 0.0 6.1e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase ADH_zinc_N PF00107.26 KOO23939.1 - 0.0026 17.7 0.0 0.033 14.2 0.0 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase CMAS PF02353.20 KOO23939.1 - 0.0059 15.9 0.0 0.0083 15.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase GidB PF02527.15 KOO23939.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G MetW PF07021.12 KOO23939.1 - 0.015 14.9 0.0 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Cons_hypoth95 PF03602.15 KOO23939.1 - 0.033 13.8 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PrmA PF06325.13 KOO23939.1 - 0.076 12.4 0.0 0.09 12.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 KOO23939.1 - 0.15 11.8 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 KOO23939.1 - 0.16 11.4 0.0 0.21 11.0 0.0 1.1 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_18 PF12847.7 KOO23939.1 - 0.17 11.8 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 KOO23939.1 - 0.18 11.5 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase PTEN_C2 PF10409.9 KOO23940.1 - 1.1e-12 47.9 0.0 2.2e-12 46.9 0.0 1.5 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein PH PF00169.29 KOO23940.1 - 0.1 13.1 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 PH domain Gln-synt_C PF00120.24 KOO23941.1 - 6.7e-98 327.9 0.0 7.8e-98 327.6 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N_2 PF16952.5 KOO23941.1 - 6.2e-06 26.0 0.0 5e-05 23.1 0.0 2.4 1 1 0 1 1 1 1 Glutamine synthetase N-terminal domain Gln-synt_N PF03951.19 KOO23941.1 - 0.00036 20.2 0.0 0.00076 19.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain ABC2_membrane PF01061.24 KOO23942.1 - 2e-32 112.4 22.8 2e-32 112.4 22.8 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KOO23942.1 - 1.2e-23 84.1 0.0 1.7e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOO23942.1 - 7.6e-08 32.5 0.0 0.0069 16.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO23942.1 - 8.1e-05 22.2 0.0 0.00021 20.8 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOO23942.1 - 0.00011 21.9 1.5 0.00016 21.3 0.5 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 KOO23942.1 - 0.0015 18.9 0.1 0.0025 18.2 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 KOO23942.1 - 0.0026 16.9 0.3 0.015 14.4 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.6 KOO23942.1 - 0.0072 16.8 0.1 0.012 16.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO23942.1 - 0.017 14.9 0.1 0.027 14.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain PDR_CDR PF06422.12 KOO23942.1 - 0.019 14.9 0.1 0.019 14.9 0.1 2.9 2 1 1 3 3 3 0 CDR ABC transporter AAA_22 PF13401.6 KOO23942.1 - 0.02 15.2 0.1 0.043 14.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 KOO23942.1 - 0.02 15.3 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KOO23942.1 - 0.021 14.8 0.1 0.038 13.9 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 KOO23942.1 - 0.022 14.7 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 KOO23942.1 - 0.026 15.1 0.0 0.044 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KOO23942.1 - 0.058 13.3 0.0 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 KOO23942.1 - 0.12 12.0 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO23942.1 - 0.17 12.1 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KOO23942.1 - 0.18 11.4 0.1 0.29 10.7 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 KOO23942.1 - 0.21 10.7 0.1 0.32 10.1 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain Epimerase PF01370.21 KOO23943.1 - 7.7e-09 35.4 0.1 4e-08 33.0 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Abhydrolase_1 PF00561.20 KOO23943.1 - 8.6e-09 35.4 0.0 3.6e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Polysacc_synt_2 PF02719.15 KOO23943.1 - 0.00045 19.5 0.0 0.1 11.7 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 KOO23943.1 - 0.0005 19.3 0.0 0.0022 17.2 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein PhyH PF05721.13 KOO23944.1 - 9e-23 81.6 0.0 1.3e-22 81.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) TipAS PF07739.13 KOO23945.1 - 0.12 12.9 0.0 0.34 11.5 0.0 1.8 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain CorC_HlyC PF03471.17 KOO23946.1 - 0.18 11.8 0.0 0.18 11.8 0.0 1.1 1 0 0 1 1 1 0 Transporter associated domain Stevor PF17410.2 KOO23948.1 - 0.00054 19.6 0.3 0.00075 19.1 0.3 1.1 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame PI3_PI4_kinase PF00454.27 KOO23949.1 - 2.5e-45 155.3 0.0 3.7e-45 154.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 KOO23949.1 - 3.6e-13 49.1 0.0 7.1e-13 48.1 0.0 1.5 1 0 0 1 1 1 1 FATC domain UBM PF14377.6 KOO23950.1 - 4.5 6.9 10.6 8.1 6.1 2.0 2.8 2 0 0 2 2 2 0 Ubiquitin binding region MnmE_helical PF12631.7 KOO23950.1 - 5.6 7.1 14.0 13 5.9 14.0 1.5 1 0 0 1 1 1 0 MnmE helical domain EF-hand_1 PF00036.32 KOO23951.1 - 8.3e-36 118.9 20.2 1.2e-09 37.0 1.6 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO23951.1 - 5.2e-31 106.9 11.8 5.8e-17 61.9 0.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23951.1 - 3.8e-28 95.0 12.0 1.3e-09 37.2 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO23951.1 - 5.6e-26 90.2 13.0 1.1e-12 47.6 1.3 3.7 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO23951.1 - 1.5e-18 65.3 19.1 4.6e-06 25.9 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KOO23951.1 - 1e-16 61.0 0.6 9.4e-08 32.3 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO23951.1 - 6.4e-07 29.3 9.3 0.072 13.1 0.8 3.3 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SurA_N_3 PF13624.6 KOO23951.1 - 7.1e-05 22.7 2.3 0.04 13.7 0.2 2.1 1 1 1 2 2 2 2 SurA N-terminal domain Dockerin_1 PF00404.18 KOO23951.1 - 0.00017 21.7 0.7 0.61 10.3 0.1 2.4 2 0 0 2 2 2 2 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KOO23951.1 - 0.00032 21.0 1.5 0.4 11.0 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO23951.1 - 0.00051 20.3 2.1 0.17 12.2 0.3 2.5 1 1 0 2 2 2 2 EF-hand domain SUB1_ProdP9 PF18213.1 KOO23951.1 - 0.009 15.8 0.4 0.009 15.8 0.4 2.0 1 1 1 2 2 2 1 SUB1 protease Prodomain ProdP9 PMBR PF09373.10 KOO23951.1 - 0.011 15.9 0.9 47 4.4 0.0 4.6 5 0 0 5 5 5 0 Pseudomurein-binding repeat DUF853 PF05872.12 KOO23951.1 - 0.011 14.4 0.4 0.89 8.1 0.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) Sigma54_CBD PF04963.13 KOO23951.1 - 0.013 15.4 0.5 0.018 14.9 0.5 1.2 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain SurA_N_2 PF13623.6 KOO23951.1 - 0.016 15.1 3.5 1 9.2 0.8 2.7 1 1 1 2 2 2 0 SurA N-terminal domain TerB PF05099.13 KOO23951.1 - 0.031 14.2 4.8 0.08 12.9 0.1 2.7 1 1 2 3 3 3 0 Tellurite resistance protein TerB Caleosin PF05042.13 KOO23951.1 - 0.035 14.0 2.3 7.7 6.4 0.0 3.5 1 1 3 4 4 4 0 Caleosin related protein DUF3008 PF11450.8 KOO23951.1 - 0.081 13.1 0.2 0.081 13.1 0.2 2.9 4 0 0 4 4 4 0 Protein of unknwon function (DUF3008) EF-hand_11 PF08976.11 KOO23951.1 - 0.084 13.7 0.3 15 6.5 0.1 2.1 1 1 1 2 2 2 0 EF-hand domain FlgD PF03963.14 KOO23951.1 - 0.11 12.8 0.8 0.33 11.3 0.3 2.0 2 1 0 2 2 2 0 Flagellar hook capping protein - N-terminal region DUF3349 PF11829.8 KOO23951.1 - 0.12 13.1 2.1 5.2 7.9 0.1 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) LETM1 PF07766.13 KOO23951.1 - 0.16 11.3 2.9 0.23 10.8 1.0 2.1 1 1 0 1 1 1 0 LETM1-like protein Glyco_transf_92 PF01697.27 KOO23951.1 - 0.17 11.5 0.3 0.25 10.9 0.3 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 92 DUF21 PF01595.20 KOO23951.1 - 0.26 11.0 0.6 0.6 9.8 0.2 1.8 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain SHOCT PF09851.9 KOO23951.1 - 0.31 10.8 0.4 0.31 10.8 0.4 3.6 5 0 0 5 5 4 0 Short C-terminal domain MgtE_N PF03448.17 KOO23951.1 - 1 10.0 6.1 0.23 12.1 1.2 2.3 3 0 0 3 3 2 0 MgtE intracellular N domain Gp-FAR-1 PF05823.12 KOO23951.1 - 1.1 9.6 6.3 1.7 9.0 0.3 3.0 2 1 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) EF-hand_10 PF14788.6 KOO23951.1 - 1.3 8.9 6.0 2.1 8.3 1.6 3.0 3 1 0 3 3 3 0 EF hand SRI PF08236.11 KOO23951.1 - 1.5 9.1 4.7 1.4 9.1 0.1 2.9 2 1 1 3 3 3 0 SRI (Set2 Rpb1 interacting) domain Ribosomal_L31e PF01198.19 KOO23953.1 - 8.4e-41 138.1 0.3 1.1e-40 137.7 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e Vsr PF03852.15 KOO23953.1 - 0.088 12.7 0.2 8.5 6.3 0.0 2.2 1 1 1 2 2 2 0 DNA mismatch endonuclease Vsr Mqo PF06039.15 KOO23955.1 - 1.2e-128 429.7 0.0 1.6e-128 429.4 0.0 1.1 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) EF-hand_7 PF13499.6 KOO23955.1 - 1.8e-10 41.1 0.0 1.4e-09 38.2 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO23955.1 - 1.1e-09 37.3 0.1 0.00072 18.9 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO23955.1 - 2.5e-09 36.8 0.2 4e-05 23.4 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO23955.1 - 2.8e-09 36.2 0.2 0.0024 17.6 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO23955.1 - 2.5e-08 32.9 0.6 0.0024 17.3 0.0 2.9 3 0 0 3 3 3 2 EF hand DAO PF01266.24 KOO23955.1 - 7.3e-05 22.5 0.0 0.00036 20.2 0.0 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase SPARC_Ca_bdg PF10591.9 KOO23955.1 - 0.096 13.0 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region GSH_synth_ATP PF03917.17 KOO23956.1 - 3.8e-115 384.7 0.0 4.4e-115 384.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 KOO23956.1 - 1.9e-29 102.1 0.0 4.5e-29 100.9 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic glutathione synthase PP2C PF00481.21 KOO23957.1 - 1.9e-19 70.3 0.0 8.3e-19 68.2 0.0 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO23957.1 - 4.5e-09 36.3 0.3 4.5e-09 36.3 0.3 2.5 2 1 0 2 2 2 1 Protein phosphatase 2C DUF4575 PF15143.6 KOO23957.1 - 0.0015 18.7 2.0 0.0035 17.6 2.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4575) Spc7 PF08317.11 KOO23957.1 - 0.03 13.2 5.6 0.049 12.5 5.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Mitofilin PF09731.9 KOO23957.1 - 0.034 13.0 12.6 0.055 12.3 12.6 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein TIG PF01833.24 KOO23959.1 - 3.7e-45 151.9 33.4 3.3e-11 43.1 0.2 6.6 6 0 0 6 6 6 5 IPT/TIG domain G8 PF10162.9 KOO23959.1 - 1.2e-39 135.2 0.0 6.7e-25 87.5 0.0 2.9 2 0 0 2 2 2 2 G8 domain ILEI PF15711.5 KOO23959.1 - 2.4e-07 31.2 0.0 5.3e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Interleukin-like EMT inducer Beta_helix PF13229.6 KOO23959.1 - 9.9e-06 25.5 21.4 0.0021 17.9 4.5 5.9 4 3 1 5 5 5 3 Right handed beta helix region F5_F8_type_C PF00754.25 KOO23959.1 - 0.017 15.2 0.0 0.049 13.7 0.0 1.8 1 0 0 1 1 1 0 F5/8 type C domain TPR_11 PF13414.6 KOO23961.1 - 0.00039 20.0 0.4 0.00082 19.0 0.4 1.5 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.17 KOO23961.1 - 0.00086 19.2 0.3 0.00086 19.2 0.3 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23961.1 - 0.0016 18.2 0.3 0.003 17.3 0.3 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat MIT PF04212.18 KOO23961.1 - 0.0048 16.9 8.8 0.16 12.1 4.3 2.3 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 KOO23961.1 - 0.13 12.9 0.3 0.13 12.9 0.3 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23962.1 - 2e-06 27.6 0.6 0.048 13.9 0.0 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23962.1 - 3.1e-06 26.8 2.9 0.0034 17.1 0.2 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23962.1 - 6.2e-06 25.9 8.1 0.017 15.2 0.2 3.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23962.1 - 0.0016 18.9 3.7 0.25 11.9 0.2 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat SEN1_N PF12726.7 KOO23962.1 - 0.0043 15.4 0.0 0.037 12.3 0.0 2.1 1 1 1 2 2 2 2 SEN1 N terminal TPR_9 PF13371.6 KOO23962.1 - 0.0044 17.1 0.8 0.0044 17.1 0.8 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23962.1 - 0.0076 16.5 4.7 0.033 14.5 1.8 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23962.1 - 0.014 16.2 0.1 0.014 16.2 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 KOO23962.1 - 0.023 13.9 0.1 0.086 12.0 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat CdvA PF18822.1 KOO23962.1 - 0.16 11.8 0.0 0.5 10.2 0.0 1.8 1 0 0 1 1 1 0 CdvA-like coiled-coil domain TPR_17 PF13431.6 KOO23962.1 - 0.19 12.1 0.4 34 5.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23962.1 - 0.2 11.7 1.7 20 5.5 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23962.1 - 1.2 9.9 4.5 5 7.8 0.1 3.3 4 0 0 4 4 3 0 Tetratricopeptide repeat UBA PF00627.31 KOO23963.1 - 5.4e-08 32.6 0.4 1.1e-07 31.6 0.4 1.5 1 0 0 1 1 1 1 UBA/TS-N domain CUE PF02845.16 KOO23963.1 - 0.016 14.9 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 CUE domain zf-RING_5 PF14634.6 KOO23963.1 - 0.016 15.1 1.6 0.037 14.0 1.6 1.6 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 KOO23963.1 - 0.018 14.7 0.8 0.036 13.8 0.8 1.5 1 0 0 1 1 1 0 RING-like zinc finger UIM PF02809.20 KOO23963.1 - 0.056 13.4 3.7 0.23 11.5 3.7 2.2 1 0 0 1 1 1 0 Ubiquitin interaction motif zf-C3H2C3 PF17122.5 KOO23963.1 - 0.066 13.3 0.3 0.14 12.2 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger UBA_5 PF16577.5 KOO23963.1 - 0.094 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 UBA domain zf-RING_2 PF13639.6 KOO23963.1 - 0.19 12.1 5.1 1 9.7 5.3 2.0 1 1 1 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 KOO23963.1 - 0.27 11.1 1.7 0.75 9.7 1.7 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO23963.1 - 0.7 9.8 3.1 0.41 10.6 0.8 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 KOO23963.1 - 5.5 7.0 7.0 37 4.3 3.8 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Asp PF00026.23 KOO23964.1 - 4.2e-23 82.3 0.0 5.5e-22 78.6 0.0 2.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO23964.1 - 5.2e-05 23.5 0.1 0.084 13.1 0.1 2.5 1 1 0 2 2 2 2 Xylanase inhibitor N-terminal Mannosyl_trans2 PF04188.13 KOO23965.1 - 6.3e-31 108.1 3.1 7.8e-31 107.8 3.1 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) DUF2079 PF09852.9 KOO23965.1 - 0.016 14.1 10.2 0.022 13.6 10.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) EF-hand_5 PF13202.6 KOO23966.1 - 8.8e-34 113.5 3.8 3.2e-05 23.2 0.0 6.2 6 0 0 6 6 6 6 EF hand EF-hand_1 PF00036.32 KOO23966.1 - 8.9e-34 112.5 0.8 0.0002 20.7 0.0 6.2 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO23966.1 - 1.6e-31 105.5 0.3 0.0014 18.4 0.0 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.6 KOO23966.1 - 1.8e-24 85.9 0.1 8.2e-07 29.4 0.0 3.9 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO23966.1 - 9.6e-18 63.8 4.7 0.0022 17.8 0.1 6.3 3 3 3 6 6 6 6 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO23966.1 - 4.4e-11 43.1 0.0 0.0057 17.0 0.0 3.6 3 1 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Toprim PF01751.22 KOO23966.1 - 0.00067 19.9 0.3 4.4 7.6 0.0 3.2 1 1 2 3 3 3 1 Toprim domain Dockerin_1 PF00404.18 KOO23966.1 - 0.0018 18.4 6.0 1.8 8.8 0.7 4.6 4 1 1 5 5 5 1 Dockerin type I domain TPR_20 PF14561.6 KOO23966.1 - 0.0029 17.9 1.4 0.39 11.1 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat EF-hand_14 PF17959.1 KOO23966.1 - 0.012 15.9 0.1 13 6.2 0.0 3.9 4 1 1 5 5 5 0 EF-hand domain EF-hand_9 PF14658.6 KOO23966.1 - 0.032 14.5 0.8 6.1 7.3 0.0 3.7 4 1 0 4 4 4 0 EF-hand domain EF-hand_13 PF17958.1 KOO23966.1 - 0.038 13.8 0.0 19 5.2 0.0 4.0 6 0 0 6 6 6 0 EF-hand domain OAM_dimer PF16554.5 KOO23966.1 - 0.066 13.7 0.0 4.5 7.8 0.0 2.6 2 0 0 2 2 2 0 Dimerisation domain of d-ornithine 4,5-aminomutase Arm-DNA-bind_1 PF09003.10 KOO23966.1 - 0.14 12.3 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage lambda integrase, Arm DNA-binding domain MtN3_slv PF03083.16 KOO23967.1 - 1.3e-35 121.3 10.5 1.4e-21 76.3 3.6 2.3 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange SNF2_N PF00176.23 KOO23969.1 - 1.1e-71 241.4 0.3 2.2e-71 240.4 0.3 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 KOO23969.1 - 1.5e-26 92.6 0.0 4.3e-26 91.2 0.0 1.8 1 0 0 1 1 1 1 SLIDE Helicase_C PF00271.31 KOO23969.1 - 5.9e-19 68.5 0.0 1.7e-18 67.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO23969.1 - 4.1e-10 39.9 0.0 1.1e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HAND PF09110.11 KOO23969.1 - 2.9e-07 31.2 0.9 2.9e-07 31.2 0.9 2.6 2 1 0 2 2 1 1 HAND DEAD PF00270.29 KOO23969.1 - 8.9e-05 22.3 0.0 0.00024 20.9 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 KOO23969.1 - 0.00024 20.4 0.0 0.00094 18.4 0.0 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 KOO23969.1 - 0.00079 19.2 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DBINO PF13892.6 KOO23969.1 - 0.0022 18.4 3.5 0.01 16.2 3.5 2.1 1 0 0 1 1 1 1 DNA-binding domain AAA_22 PF13401.6 KOO23969.1 - 0.11 12.7 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOO23969.1 - 0.17 11.9 0.0 0.56 10.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATP11 PF06644.11 KOO23970.1 - 0.00034 20.5 0.0 0.00039 20.3 0.0 1.2 1 0 0 1 1 1 1 ATP11 protein Methyltransf_24 PF13578.6 KOO23971.1 - 0.13 13.3 0.0 0.31 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain XRN_N PF03159.18 KOO23972.1 - 1.4e-75 253.9 0.0 1.7e-75 253.6 0.0 1.1 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 KOO23972.1 - 5.1e-18 65.3 0.0 6.8e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Xrn1 helical domain COMM_domain PF07258.14 KOO23973.1 - 2.2e-06 27.7 0.0 3.1e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 COMM domain WD40 PF00400.32 KOO23975.1 - 3.3e-22 78.4 3.6 6.1e-06 26.9 0.1 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO23975.1 - 1.6e-15 57.2 0.0 0.021 15.1 0.0 5.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO23975.1 - 5e-06 25.7 0.7 0.13 11.2 0.0 3.3 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOO23975.1 - 4e-05 23.6 0.0 8.6e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOO23975.1 - 0.0008 18.2 0.1 2 7.0 0.0 3.2 1 1 2 3 3 3 2 Nucleoporin Nup120/160 TPR_2 PF07719.17 KOO23976.1 - 1.6e-14 52.7 12.2 4.5e-05 23.2 1.4 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO23976.1 - 1.8e-12 46.5 2.7 0.00024 20.8 0.5 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23976.1 - 1.7e-11 43.4 1.6 0.022 14.9 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat DnaJ PF00226.31 KOO23976.1 - 3.8e-11 42.9 0.0 8.3e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_11 PF13414.6 KOO23976.1 - 9.6e-09 34.8 2.5 4.9e-05 22.9 0.5 2.9 1 1 1 2 2 2 2 TPR repeat TPR_17 PF13431.6 KOO23976.1 - 7.6e-07 29.1 2.4 0.0034 17.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23976.1 - 2.5e-05 24.8 7.7 2.5e-05 24.8 7.7 5.8 4 2 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO23976.1 - 0.0078 16.3 6.2 0.0078 16.3 6.2 4.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO23976.1 - 0.011 15.7 5.2 0.3 11.2 0.1 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23976.1 - 0.11 13.3 0.2 0.1 13.5 3.3 6.6 3 3 3 6 6 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO23976.1 - 0.58 10.3 4.6 4.4 7.5 0.1 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 KOO23976.1 - 3.3 8.1 16.9 2.2 8.6 0.7 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat RHD3 PF05879.12 KOO23977.1 - 2.2e-10 39.4 0.0 7.3e-09 34.4 0.0 2.6 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) FAD_binding_6 PF00970.24 KOO23978.1 - 4.5e-09 36.6 0.0 7.6e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KOO23978.1 - 1.9e-07 31.7 0.1 7.7e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOO23978.1 - 0.0038 17.3 0.1 0.059 13.5 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAM76 PF16046.5 KOO23979.1 - 0.00076 18.9 4.5 0.0018 17.7 1.2 2.0 1 1 1 2 2 2 2 FAM76 protein APG6_N PF17675.1 KOO23979.1 - 0.0015 19.1 6.1 0.0015 19.1 6.1 2.0 3 0 0 3 3 3 1 Apg6 coiled-coil region EF-hand_14 PF17959.1 KOO23979.1 - 0.024 15.0 0.3 0.078 13.3 0.0 1.9 2 1 0 2 2 2 0 EF-hand domain NPV_P10 PF05531.12 KOO23979.1 - 0.063 13.8 3.7 0.16 12.4 1.9 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.9 KOO23979.1 - 0.12 11.4 1.2 0.15 11.1 1.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2730 PF10805.8 KOO23979.1 - 0.36 11.0 3.2 0.68 10.1 1.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF724 PF05266.14 KOO23979.1 - 0.41 10.5 7.6 0.81 9.5 7.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PhoU PF01895.19 KOO23979.1 - 0.82 10.2 4.4 0.59 10.6 1.4 2.0 1 1 1 2 2 2 0 PhoU domain PAXX PF15384.6 KOO23979.1 - 0.85 9.3 5.8 12 5.6 0.0 2.3 2 0 0 2 2 2 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Spc7 PF08317.11 KOO23979.1 - 1.1 8.1 10.1 1.7 7.5 10.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Spc24 PF08286.11 KOO23979.1 - 4.5 7.6 8.8 3.2 8.0 6.6 1.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 2Fe-2S_thioredx PF01257.19 KOO23980.1 - 3.2e-51 173.0 0.6 8.7e-48 161.9 0.1 2.1 2 0 0 2 2 2 2 Thioredoxin-like [2Fe-2S] ferredoxin FAST_1 PF06743.15 KOO23981.1 - 0.0017 18.3 0.0 0.56 10.2 0.0 3.2 2 1 1 3 3 3 3 FAST kinase-like protein, subdomain 1 HEAT_EZ PF13513.6 KOO23981.1 - 0.1 13.1 0.2 0.1 13.1 0.2 5.1 5 0 0 5 5 5 0 HEAT-like repeat DUF3886 PF13025.6 KOO23981.1 - 0.12 12.6 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Glyco_hydro_10 PF00331.20 KOO23982.1 - 8.8e-11 41.5 0.0 1.7e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_4_9 PF02018.17 KOO23982.1 - 1.7e-09 38.1 0.3 0.0023 18.2 0.0 3.4 3 0 0 3 3 3 2 Carbohydrate binding domain LRR_6 PF13516.6 KOO23984.1 - 6.4e-12 44.5 1.0 0.0056 16.6 0.0 3.6 3 0 0 3 3 3 3 Leucine Rich repeat LRR_8 PF13855.6 KOO23984.1 - 0.17 11.6 0.1 1.7e+02 2.1 0.0 3.4 3 1 0 3 3 3 0 Leucine rich repeat CTP_transf_1 PF01148.20 KOO23985.1 - 8.9e-54 183.0 18.8 6.9e-53 180.1 18.8 2.0 1 1 0 1 1 1 1 Cytidylyltransferase family Abhydrolase_9 PF10081.9 KOO23986.1 - 0.045 12.8 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family Methyltransf_16 PF10294.9 KOO23987.1 - 4.7e-16 59.0 0.0 5.9e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 KOO23987.1 - 1e-06 28.4 0.1 1.8e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.16 KOO23987.1 - 8.3e-05 22.4 0.0 0.00012 21.9 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.13 KOO23987.1 - 0.00063 19.2 0.1 0.00078 18.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 KOO23987.1 - 0.0027 17.5 0.0 0.0052 16.6 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO23987.1 - 0.011 16.5 0.2 0.023 15.4 0.2 1.7 1 1 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 KOO23987.1 - 0.042 13.5 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Arm PF00514.23 KOO23989.1 - 4.3e-31 106.0 92.8 0.0007 19.5 0.0 26.0 28 0 0 28 28 28 14 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 KOO23989.1 - 0.0013 18.3 0.0 43 3.5 0.0 6.4 7 0 0 7 7 7 0 Armadillo-like Adaptin_N PF01602.20 KOO23989.1 - 0.0042 15.7 8.6 1.3 7.5 0.0 5.6 5 1 0 5 5 5 3 Adaptin N terminal region CLASP_N PF12348.8 KOO23989.1 - 0.06 12.9 0.9 1.5 8.3 0.0 3.6 4 1 0 4 4 4 0 CLASP N terminal Proteasom_PSMB PF10508.9 KOO23989.1 - 3.5 6.0 14.7 0.74 8.2 0.0 5.5 6 1 0 6 6 6 0 Proteasome non-ATPase 26S subunit RPE65 PF03055.15 KOO23990.1 - 3.3e-35 122.2 0.0 1.1e-17 64.4 0.0 2.0 1 1 1 2 2 2 2 Retinal pigment epithelial membrane protein TPR_1 PF00515.28 KOO23991.1 - 2.9e-11 42.7 1.5 6.8e-05 22.5 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO23991.1 - 4.5e-10 38.9 3.7 2.6e-05 24.0 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO23991.1 - 3.9e-05 23.3 0.8 0.83 9.4 0.1 3.3 2 1 1 3 3 3 3 TPR repeat TPR_9 PF13371.6 KOO23991.1 - 0.00012 22.1 2.7 0.00046 20.3 2.7 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO23991.1 - 0.00019 21.9 9.3 0.0027 18.4 0.4 4.1 3 2 1 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO23991.1 - 0.00032 20.7 0.4 0.035 14.3 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO23991.1 - 0.00068 20.2 8.7 0.0014 19.2 1.9 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO23991.1 - 0.0021 18.6 2.4 0.0021 18.6 2.4 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO23991.1 - 0.0039 17.4 6.7 0.041 14.2 1.9 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat DUF3846 PF12957.7 KOO23991.1 - 0.04 14.2 0.0 0.091 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3846) ANAPC3 PF12895.7 KOO23991.1 - 0.1 12.8 3.7 0.15 12.3 1.1 2.5 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 KOO23991.1 - 0.14 12.6 5.4 0.65 10.4 4.7 2.5 2 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 KOO23991.1 - 0.31 11.8 2.5 17 6.3 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat PUB PF09409.10 KOO23993.1 - 0.00036 20.4 0.0 0.00064 19.6 0.0 1.3 1 0 0 1 1 1 1 PUB domain ELMO_CED12 PF04727.13 KOO23994.1 - 8.1e-42 143.3 0.3 1.3e-41 142.6 0.1 1.5 2 0 0 2 2 2 1 ELMO/CED-12 family Sod_Fe_C PF02777.18 KOO23994.1 - 0.1 12.8 0.0 0.35 11.1 0.0 1.8 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, C-terminal domain Cyclin_N PF00134.23 KOO23996.1 - 1.8e-28 98.8 0.1 6.2e-23 80.9 0.0 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOO23996.1 - 1.7e-06 28.1 0.4 3.4e-06 27.2 0.4 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Tam41_Mmp37 PF09139.11 KOO23998.1 - 6.8e-70 236.1 0.0 7.8e-70 235.9 0.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial FH2 PF02181.23 KOO23999.1 - 1.2e-37 130.0 0.1 3.6e-18 65.9 0.1 3.0 1 1 1 2 2 2 2 Formin Homology 2 Domain Cytochrom_B562 PF07361.11 KOO23999.1 - 1.1 10.0 4.2 0.81 10.4 0.2 2.5 3 1 0 3 3 3 0 Cytochrome b562 PEP-utilisers_N PF05524.13 KOO23999.1 - 1.3 9.2 7.5 0.67 10.1 4.7 1.9 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal Peptidase_M18 PF02127.15 KOO24000.1 - 1.6e-92 310.6 0.0 2.1e-91 306.9 0.0 1.9 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) HALZ PF02183.18 KOO24001.1 - 0.02 15.1 0.4 0.043 14.0 0.4 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper NRBF2 PF08961.10 KOO24001.1 - 0.77 9.3 4.5 0.37 10.4 0.6 2.1 2 1 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator DUF3924 PF13062.6 KOO24004.1 - 0.00014 21.8 0.0 8.9 6.3 0.0 4.4 5 0 0 5 5 5 3 Protein of unknown function (DUF3924) DUF2656 PF10847.8 KOO24004.1 - 0.026 14.6 7.1 0.23 11.6 0.1 4.5 2 1 2 5 5 5 0 Protein of unknown function (DUF2656) Rho_RNA_bind PF07497.12 KOO24004.1 - 4.4 7.2 6.1 36 4.3 0.0 4.2 6 0 0 6 6 6 0 Rho termination factor, RNA-binding domain Arm PF00514.23 KOO24005.1 - 1.9e-89 291.3 63.4 2.5e-09 36.9 0.2 18.9 19 0 0 19 19 19 14 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO24005.1 - 2.9e-20 72.4 51.3 0.0002 21.8 2.1 11.5 10 1 2 12 12 12 7 HEAT-like repeat Atx10homo_assoc PF09759.9 KOO24005.1 - 7.6e-15 54.7 30.5 0.019 14.9 0.2 9.4 4 4 5 9 9 9 7 Spinocerebellar ataxia type 10 protein domain CRS1_YhbY PF01985.21 KOO24005.1 - 0.00062 19.9 1.6 12 6.1 0.0 5.9 7 0 0 7 7 7 2 CRS1 / YhbY (CRM) domain Adaptin_N PF01602.20 KOO24005.1 - 0.0092 14.6 0.1 1.3 7.4 0.0 3.5 2 2 1 3 3 3 1 Adaptin N terminal region PreAtp-grasp PF18604.1 KOO24005.1 - 0.01 15.5 0.2 2.5 7.8 0.0 2.6 2 0 0 2 2 2 0 Pre ATP-grasp domain Sigma70_r1_1 PF03979.14 KOO24005.1 - 0.02 15.0 0.5 4 7.6 0.1 2.5 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 HEAT PF02985.22 KOO24005.1 - 0.2 12.0 22.2 33 5.1 0.4 10.0 13 0 0 13 13 13 0 HEAT repeat Arm_2 PF04826.13 KOO24005.1 - 0.21 11.0 15.6 3.7 6.9 1.7 6.3 3 2 2 5 5 5 0 Armadillo-like SET PF00856.28 KOO24006.1 - 2.1e-10 41.3 0.0 3e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 SET domain Abhydrolase_3 PF07859.13 KOO24007.1 - 2.6e-07 30.7 0.0 5.3e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold TPT PF03151.16 KOO24007.1 - 5.7e-07 29.2 12.4 9.8e-07 28.4 12.4 1.4 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 KOO24007.1 - 4.6e-05 22.8 12.4 9e-05 21.8 12.4 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO24007.1 - 0.0023 18.1 28.2 0.0035 17.5 10.0 2.4 2 0 0 2 2 2 2 EamA-like transporter family Ion_trans PF00520.31 KOO24009.1 - 2.9e-23 82.4 5.3 4.3e-23 81.8 5.3 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO24009.1 - 2.7e-08 33.7 1.8 6.8e-08 32.4 1.8 1.7 1 0 0 1 1 1 1 Ion channel DUF5529 PF17669.1 KOO24009.1 - 0.17 11.9 0.2 0.3 11.1 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5529) EF-hand_7 PF13499.6 KOO24010.1 - 1.5e-10 41.4 2.6 1.6e-06 28.5 0.3 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO24010.1 - 3.6e-09 35.8 7.9 0.008 16.0 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO24010.1 - 2.3e-08 33.0 8.2 0.012 15.1 0.6 3.7 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 KOO24010.1 - 6.7e-07 28.5 9.1 0.008 15.6 0.3 3.7 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO24010.1 - 0.068 13.0 5.9 0.99 9.3 0.6 3.0 3 0 0 3 3 3 0 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO24010.1 - 0.15 12.4 0.2 12 6.3 0.0 2.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region RRT14 PF17075.5 KOO24010.1 - 0.15 12.1 0.6 0.27 11.3 0.6 1.2 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 Pectate_lyase_2 PF06917.12 KOO24010.1 - 0.17 10.4 0.0 0.26 9.8 0.0 1.1 1 0 0 1 1 1 0 Periplasmic pectate lyase Sel1 PF08238.12 KOO24011.1 - 4.2e-10 40.0 10.7 8.9e-05 23.0 0.3 3.7 3 0 0 3 3 3 3 Sel1 repeat 2OG-FeII_Oxy_3 PF13640.6 KOO24011.1 - 0.074 13.9 0.0 0.14 13.1 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily ADPrib_exo_Tox PF03496.14 KOO24012.1 - 2.5e-09 36.8 0.0 8.8e-09 35.0 0.0 1.9 2 1 0 2 2 2 1 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO24012.1 - 6.9e-08 32.0 0.0 6.9e-08 32.0 0.0 2.1 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase FapA PF03961.13 KOO24012.1 - 8.3 4.9 12.5 3.8 6.0 9.2 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A Abhydrolase_1 PF00561.20 KOO24014.1 - 2.7e-19 69.8 0.0 6.4e-19 68.6 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO24014.1 - 4.9e-10 39.1 0.0 1.6e-09 37.4 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO24014.1 - 4.4e-08 34.0 2.5 8.7e-08 33.0 2.5 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOO24014.1 - 3.5e-05 23.4 0.0 0.0032 17.0 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 KOO24014.1 - 0.083 12.7 0.0 0.7 9.6 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase ADSL_C PF10397.9 KOO24016.1 - 0.088 13.4 0.1 0.23 12.0 0.0 1.8 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminus OTU PF02338.19 KOO24017.1 - 2.2e-17 63.8 0.0 4e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 KOO24017.1 - 3.8e-05 23.3 0.9 0.22 11.0 0.1 2.2 2 0 0 2 2 2 2 Peptidase C65 Otubain Axin_b-cat_bind PF08833.10 KOO24017.1 - 0.006 16.7 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 Axin beta-catenin binding domain ERM PF00769.19 KOO24018.1 - 0.019 14.8 16.4 0.024 14.5 16.4 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family KLRAQ PF10205.9 KOO24018.1 - 0.025 14.8 8.2 0.63 10.3 3.7 2.4 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Fez1 PF06818.15 KOO24018.1 - 0.027 14.9 14.4 0.02 15.3 11.9 1.8 1 1 1 2 2 2 0 Fez1 DUF641 PF04859.12 KOO24018.1 - 0.065 13.6 9.8 0.45 10.9 9.8 2.1 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) GAS PF13851.6 KOO24018.1 - 0.069 12.5 8.6 0.12 11.7 8.6 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding MCC-bdg_PDZ PF10506.9 KOO24018.1 - 0.087 12.8 6.2 36 4.5 6.2 2.7 1 1 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome UPF0242 PF06785.11 KOO24018.1 - 0.11 12.6 4.3 0.15 12.1 4.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Herpes_UL25 PF01499.16 KOO24018.1 - 0.12 10.8 6.9 0.16 10.5 6.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family TMF_DNA_bd PF12329.8 KOO24018.1 - 0.15 12.1 5.8 0.3 11.1 4.3 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding TMF_TATA_bd PF12325.8 KOO24018.1 - 0.24 11.6 11.8 0.3 11.3 2.8 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.10 KOO24018.1 - 0.44 10.7 3.6 6.2 7.0 1.8 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Csm1_N PF18504.1 KOO24018.1 - 0.8 10.1 7.5 1.2 9.5 1.5 2.8 1 1 2 3 3 3 0 Csm1 N-terminal domain AAA_13 PF13166.6 KOO24018.1 - 1 7.9 4.8 1.3 7.6 4.8 1.1 1 0 0 1 1 1 0 AAA domain CDPS PF16715.5 KOO24018.1 - 1.3 8.6 10.3 1.9 8.1 10.3 1.1 1 0 0 1 1 1 0 Cyclodipeptide synthase DUF4404 PF14357.6 KOO24018.1 - 3.2 8.5 5.9 0.54 10.9 0.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) Atrophin-1 PF03154.15 KOO24018.1 - 7.8 4.6 8.8 9.3 4.4 8.8 1.2 1 0 0 1 1 1 0 Atrophin-1 family Pkinase PF00069.25 KOO24019.1 - 1.3e-53 182.1 0.0 2.2e-51 174.7 0.0 2.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24019.1 - 1.1e-29 103.5 0.0 1.8e-25 89.7 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.14 KOO24019.1 - 8.1e-05 22.1 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO24019.1 - 0.0089 16.0 0.9 1.2 9.0 0.0 3.1 2 1 0 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO24019.1 - 0.19 10.6 0.0 0.55 9.1 0.0 1.7 1 1 0 1 1 1 0 Haspin like kinase domain CRAL_TRIO PF00650.20 KOO24020.1 - 1.3e-26 93.2 0.0 1.7e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain SOUL PF04832.12 KOO24021.1 - 3.1e-43 147.9 0.6 1.1e-41 142.8 0.6 2.0 1 1 0 1 1 1 1 SOUL heme-binding protein DUF3382 PF11862.8 KOO24022.1 - 0.006 16.8 1.5 0.0063 16.8 0.5 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3382) Sugar_transport PF06800.12 KOO24022.1 - 0.075 12.4 0.0 0.095 12.0 0.0 1.1 1 0 0 1 1 1 0 Sugar transport protein OAD_gamma PF04277.13 KOO24022.1 - 0.18 12.4 2.2 0.87 10.2 1.3 2.2 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain NADH-u_ox-rdase PF10785.9 KOO24023.1 - 4.1e-10 40.2 0.3 1.7e-09 38.2 0.0 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Cupin_8 PF13621.6 KOO24024.1 - 2.5e-32 112.6 0.0 2.8e-32 112.4 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO24024.1 - 9.9e-09 35.1 0.2 6.1e-08 32.5 0.2 1.9 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 KOO24024.1 - 0.00022 20.9 0.1 0.00088 18.9 0.0 2.0 2 0 0 2 2 2 1 Cupin domain JmjC PF02373.22 KOO24024.1 - 0.00029 21.3 0.1 0.0055 17.1 0.0 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase Pkinase PF00069.25 KOO24025.1 - 1.2e-57 195.3 0.0 1.4e-57 195.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24025.1 - 4.7e-36 124.4 0.0 5.7e-36 124.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO24025.1 - 9.1e-08 31.8 0.0 4.5e-06 26.2 0.0 2.2 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 KOO24025.1 - 0.00064 19.7 0.9 0.032 14.1 0.5 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO24025.1 - 0.0009 18.1 0.0 0.0014 17.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KOO24025.1 - 0.0048 15.9 0.0 0.009 15.0 0.0 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOO24025.1 - 0.07 12.5 0.1 0.1 12.0 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_S51 PF03575.17 KOO24027.1 - 0.00016 21.4 0.0 0.0015 18.2 0.0 2.3 1 1 0 1 1 1 1 Peptidase family S51 Mito_carr PF00153.27 KOO24028.1 - 1.1e-38 131.0 2.9 4.8e-18 64.9 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Use1 PF09753.9 KOO24029.1 - 2.3e-34 119.2 5.7 2.7e-34 119.0 5.7 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 DUF4795 PF16043.5 KOO24029.1 - 0.024 14.2 0.8 0.074 12.7 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) ATG16 PF08614.11 KOO24029.1 - 0.14 12.4 17.8 0.049 13.9 11.3 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CC2-LZ PF16516.5 KOO24029.1 - 0.24 11.8 8.8 0.68 10.3 0.1 3.0 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator TMCO5 PF14992.6 KOO24029.1 - 3 7.3 8.5 9.2 5.7 1.0 3.0 1 1 1 3 3 3 0 TMCO5 family QLQ PF08880.11 KOO24029.1 - 3.2 7.6 5.5 27 4.6 1.3 2.7 2 0 0 2 2 2 0 QLQ Pro_isomerase PF00160.21 KOO24030.1 - 2.9e-12 47.1 0.0 4.7e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4071 PF13281.6 KOO24031.1 - 4.3 6.3 10.9 0.18 10.8 0.8 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4071) SNF2_N PF00176.23 KOO24033.1 - 6.4e-19 67.9 0.0 2.7e-16 59.3 0.0 2.4 2 0 0 2 2 2 2 SNF2 family N-terminal domain ResIII PF04851.15 KOO24033.1 - 0.042 13.8 0.0 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DNA_methylase PF00145.17 KOO24033.1 - 0.046 13.1 0.0 1.4 8.1 0.0 2.5 2 0 0 2 2 2 0 C-5 cytosine-specific DNA methylase Telomere_Sde2_2 PF13297.6 KOO24033.1 - 0.048 13.3 0.5 0.18 11.5 0.5 2.0 1 0 0 1 1 1 0 Telomere stability C-terminal DUF3638 PF12340.8 KOO24034.1 - 2.2e-60 203.8 0.3 4.2e-60 202.9 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO24034.1 - 3.8e-13 48.6 0.1 8.7e-13 47.4 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) ubiquitin PF00240.23 KOO24034.1 - 0.002 17.8 0.0 0.0049 16.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Glyco_hydro_32N PF00251.20 KOO24034.1 - 0.83 9.2 4.6 2.8 7.4 0.3 2.4 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain COG4 PF08318.12 KOO24035.1 - 0.07 12.2 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 COG4 transport protein zf-C2H2_jaz PF12171.8 KOO24036.1 - 4.6e-07 30.0 6.8 1.1e-06 28.8 6.8 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOO24036.1 - 0.00014 22.1 4.9 0.0003 21.1 4.9 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type KIAA1430 PF13879.6 KOO24036.1 - 0.014 16.2 2.1 0.029 15.1 0.1 2.2 2 0 0 2 2 2 0 KIAA1430 homologue zf-C2H2_4 PF13894.6 KOO24036.1 - 0.032 15.1 0.6 0.062 14.2 0.6 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger eIF2A PF08662.11 KOO24037.1 - 1.1e-49 169.0 6.9 2.5e-48 164.5 1.2 3.2 3 1 1 4 4 4 3 Eukaryotic translation initiation factor eIF2A WASH-7_C PF14746.6 KOO24037.1 - 0.084 12.6 1.2 0.16 11.7 1.2 1.4 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal DUF4349 PF14257.6 KOO24038.1 - 0.00085 18.8 2.8 0.001 18.6 2.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) ERM PF00769.19 KOO24038.1 - 0.026 14.4 9.8 0.032 14.1 9.8 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF641 PF04859.12 KOO24038.1 - 0.036 14.4 2.0 0.05 13.9 2.0 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF4407 PF14362.6 KOO24038.1 - 0.19 11.1 3.2 0.22 10.8 3.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DnaJ PF00226.31 KOO24039.1 - 0.00033 20.7 0.1 0.00058 19.9 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain TadZ_N PF16968.5 KOO24040.1 - 0.053 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Pilus assembly protein TadZ N-terminal ATG22 PF11700.8 KOO24041.1 - 2e-81 274.0 16.8 2.5e-81 273.7 16.8 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 KOO24041.1 - 1.4e-09 37.4 48.4 1.4e-06 27.5 28.3 2.9 2 1 1 3 3 3 3 Major Facilitator Superfamily GMP_PDE_delta PF05351.11 KOO24042.1 - 3.8e-51 173.3 0.0 4.3e-51 173.1 0.0 1.0 1 0 0 1 1 1 1 GMP-PDE, delta subunit IF-2B PF01008.17 KOO24043.1 - 1.3e-65 221.4 0.0 2.5e-65 220.5 0.0 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family Ank_2 PF12796.7 KOO24044.1 - 6.3e-33 113.2 5.0 5.2e-12 46.2 1.4 3.4 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO24044.1 - 8.6e-19 67.7 5.1 9.4e-07 29.3 0.5 4.4 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24044.1 - 1.1e-18 65.4 1.2 0.0026 18.1 0.0 5.8 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 KOO24044.1 - 3.7e-17 62.2 5.5 1.3e-08 34.9 0.0 4.6 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO24044.1 - 2.4e-13 49.9 12.6 0.00046 20.5 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat CAP_N PF01213.19 KOO24044.1 - 0.15 11.5 25.3 0.023 14.2 6.4 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 KOO24044.1 - 0.26 11.3 9.4 3.8 7.5 3.1 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator PRIMA1 PF16101.5 KOO24044.1 - 5.9 7.0 18.3 0.96 9.5 6.4 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 EF-hand_1 PF00036.32 KOO24046.1 - 2.4e-09 36.0 0.1 0.0014 18.0 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO24046.1 - 7.9e-09 35.9 0.3 1.2e-06 28.9 0.1 3.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO24046.1 - 8.2e-09 34.7 0.0 0.0016 18.2 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO24046.1 - 2.9e-05 23.8 0.0 9.3e-05 22.2 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO24046.1 - 0.0013 18.2 0.0 0.0062 16.0 0.0 2.3 1 0 0 1 1 1 1 EF hand Spc24 PF08286.11 KOO24046.1 - 0.01 16.0 0.6 0.01 16.0 0.6 9.7 8 2 1 10 10 10 0 Spc24 subunit of Ndc80 TOBE_3 PF12857.7 KOO24046.1 - 1.6 8.7 5.5 33 4.5 0.4 3.5 2 0 0 2 2 2 0 TOBE-like domain ANAPC3 PF12895.7 KOO24047.1 - 4.1e-14 52.6 23.0 3.7e-06 27.1 0.3 5.4 5 1 1 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KOO24047.1 - 7e-13 48.9 22.3 0.00011 22.6 2.3 7.2 5 2 3 8 8 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO24047.1 - 1.8e-08 34.9 20.4 0.032 14.9 0.1 6.7 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOO24047.1 - 4.4e-08 33.3 18.4 0.25 12.3 0.1 8.5 6 2 4 10 10 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO24047.1 - 6.3e-07 29.0 29.2 0.011 15.7 0.8 8.7 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO24047.1 - 5e-06 26.6 8.7 0.0011 19.0 0.9 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO24047.1 - 0.00087 18.6 0.2 0.00087 18.6 0.2 4.2 3 2 2 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.14 KOO24047.1 - 0.0016 17.9 1.7 0.013 14.9 0.4 2.9 2 2 1 3 3 3 1 Coatomer epsilon subunit TPR_7 PF13176.6 KOO24047.1 - 0.0017 18.3 5.9 0.16 12.1 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO24047.1 - 0.0018 18.5 5.1 0.49 10.9 0.1 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO24047.1 - 0.002 18.6 1.9 1.1 10.0 0.5 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat PPR PF01535.20 KOO24047.1 - 0.0026 17.9 0.9 2.3 8.7 0.2 4.5 4 0 0 4 4 4 1 PPR repeat HrpB1_HrpK PF09613.10 KOO24047.1 - 0.0051 16.4 3.9 2.9 7.5 0.0 4.2 4 2 0 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_12 PF13424.6 KOO24047.1 - 0.0074 16.6 21.4 3 8.2 2.6 7.2 6 2 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO24047.1 - 0.04 13.8 11.2 9.1 6.3 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat PPR_2 PF13041.6 KOO24047.1 - 0.041 14.1 0.4 10 6.4 0.0 3.1 2 0 0 2 2 2 0 PPR repeat family TPR_1 PF00515.28 KOO24047.1 - 0.057 13.3 17.1 0.074 12.9 0.6 6.1 7 0 0 7 7 6 0 Tetratricopeptide repeat DUF3768 PF12599.8 KOO24047.1 - 0.062 13.3 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3768) TPR_6 PF13174.6 KOO24047.1 - 0.063 13.9 0.2 0.063 13.9 0.2 6.6 6 1 0 7 7 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO24047.1 - 0.078 13.1 20.2 0.064 13.3 1.4 5.2 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 KOO24047.1 - 0.39 11.1 9.0 5 7.6 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat ARL2_Bind_BART PF11527.8 KOO24048.1 - 3.8e-24 85.0 0.8 5.4e-24 84.5 0.8 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART Erythro_esteras PF05139.14 KOO24049.1 - 5.8e-84 282.8 1.3 5.8e-82 276.3 1.3 2.1 1 1 0 1 1 1 1 Erythromycin esterase COMM_domain PF07258.14 KOO24050.1 - 2.1e-12 47.0 0.0 2.8e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 COMM domain ACP_syn_III_C PF08541.10 KOO24051.1 - 4e-39 132.7 0.3 8.8e-39 131.6 0.1 1.8 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 KOO24051.1 - 1.2e-30 105.2 0.4 1.2e-30 105.2 0.4 3.1 4 0 0 4 4 4 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 KOO24051.1 - 2.4e-07 30.4 0.6 3.1e-05 23.5 0.0 2.5 2 1 1 3 3 3 2 Thiolase, N-terminal domain ketoacyl-synt PF00109.26 KOO24051.1 - 0.00056 19.6 5.3 0.52 9.8 0.3 4.1 2 1 1 4 4 4 2 Beta-ketoacyl synthase, N-terminal domain FAE1_CUT1_RppA PF08392.12 KOO24051.1 - 0.0034 16.7 0.0 0.033 13.5 0.0 2.0 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein Thiolase_C PF02803.18 KOO24051.1 - 0.0045 16.6 0.6 0.016 14.9 0.2 2.2 2 1 0 2 2 2 1 Thiolase, C-terminal domain Chal_sti_synt_C PF02797.15 KOO24051.1 - 0.0053 16.8 0.0 0.0093 16.0 0.0 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Ketoacyl-synt_C PF02801.22 KOO24051.1 - 0.06 13.4 0.0 15 5.6 0.0 2.6 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain RAMA PF18755.1 KOO24052.1 - 4.4e-05 23.9 0.0 5e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Restriction Enzyme Adenine Methylase Associated Ribonuc_L-PSP PF01042.21 KOO24053.1 - 2.2e-19 69.6 0.0 2.9e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP AMP-binding PF00501.28 KOO24054.1 - 2.4e-39 135.1 0.2 4.5e-39 134.2 0.2 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Glyco_transf_90 PF05686.12 KOO24054.1 - 3.4e-22 78.9 0.0 9.9e-15 54.3 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 90 PAN_1 PF00024.26 KOO24054.1 - 0.012 15.6 0.4 0.029 14.3 0.4 1.6 1 0 0 1 1 1 0 PAN domain His_Phos_1 PF00300.22 KOO24055.1 - 5.8e-66 221.9 0.8 1.9e-25 89.7 0.0 4.4 3 1 1 4 4 4 4 Histidine phosphatase superfamily (branch 1) Kelch_5 PF13854.6 KOO24059.1 - 1e-28 98.8 4.3 1.4e-05 25.0 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KOO24059.1 - 1.1e-27 94.8 8.7 2.1e-06 27.5 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KOO24059.1 - 1.9e-27 94.5 5.9 2.6e-07 30.1 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KOO24059.1 - 3.6e-26 90.9 14.8 1.3e-05 25.3 0.0 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO24059.1 - 8.8e-24 83.0 6.8 1.7e-05 24.9 0.0 6.1 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KOO24059.1 - 1.5e-21 76.1 13.6 4.9e-05 23.3 0.1 6.5 6 1 0 6 6 6 6 Galactose oxidase, central domain CENP-F_leu_zip PF10473.9 KOO24060.1 - 0.0017 18.3 34.1 0.019 15.0 1.8 5.1 3 1 0 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YvrJ PF12841.7 KOO24060.1 - 0.0024 17.3 0.9 1.5 8.4 0.1 2.7 2 0 0 2 2 2 2 YvrJ protein family TPR_MLP1_2 PF07926.12 KOO24060.1 - 0.0056 16.7 13.3 0.0056 16.7 13.3 5.8 2 1 3 5 5 5 1 TPR/MLP1/MLP2-like protein CEP209_CC5 PF16574.5 KOO24060.1 - 0.0061 16.7 6.1 0.0061 16.7 6.1 3.9 4 1 1 5 5 5 1 Coiled-coil region of centrosome protein CE290 Fez1 PF06818.15 KOO24060.1 - 0.037 14.5 34.2 0.22 12.0 15.5 3.7 1 1 1 3 3 3 0 Fez1 DUF5446 PF17522.2 KOO24060.1 - 0.041 14.0 9.8 1 9.6 1.0 4.3 4 0 0 4 4 4 0 Family of unknown function (DUF5446) APG6_N PF17675.1 KOO24060.1 - 0.18 12.3 51.0 0.27 11.8 3.2 4.6 1 1 3 4 4 4 0 Apg6 coiled-coil region DUF1664 PF07889.12 KOO24060.1 - 0.19 11.8 15.4 0.48 10.5 0.9 4.2 5 0 0 5 5 4 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 KOO24060.1 - 0.23 11.8 13.8 0.17 12.2 0.9 4.6 5 1 0 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 WD40_alt PF14077.6 KOO24060.1 - 0.27 11.1 4.5 1.2 9.0 0.1 3.6 4 0 0 4 4 4 0 Alternative WD40 repeat motif GAS PF13851.6 KOO24060.1 - 0.72 9.2 38.9 0.029 13.7 8.6 5.0 2 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding DUF948 PF06103.11 KOO24060.1 - 0.78 10.0 5.6 13 6.1 1.5 4.1 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Kinesin_assoc PF16183.5 KOO24060.1 - 0.81 9.8 8.5 0.14 12.3 1.9 2.5 2 1 0 2 2 2 0 Kinesin-associated Fib_alpha PF08702.10 KOO24060.1 - 2 8.6 9.5 3.8 7.7 0.2 3.8 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family CALCOCO1 PF07888.11 KOO24060.1 - 4.5 6.0 45.3 0.67 8.7 13.9 3.2 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Atg14 PF10186.9 KOO24060.1 - 9.5 5.2 30.8 2 7.5 7.9 3.1 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ufd2P_core PF10408.9 KOO24061.1 - 2.7e-53 181.6 0.0 7.8e-30 104.1 0.0 2.2 1 1 0 2 2 2 2 Ubiquitin elongating factor core UQ_con PF00179.26 KOO24061.1 - 1.8e-18 66.6 0.0 3.3e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KOO24061.1 - 6.6e-05 22.8 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 UEV domain WW PF00397.26 KOO24062.1 - 1.7e-06 28.0 1.7 3.3e-06 27.1 1.7 1.5 1 0 0 1 1 1 1 WW domain Pox_Ag35 PF03286.14 KOO24062.1 - 3.2 7.5 9.5 0.33 10.7 5.1 1.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein FAM176 PF14851.6 KOO24062.1 - 7.9 6.1 5.7 11 5.6 5.7 1.2 1 0 0 1 1 1 0 FAM176 family TPH PF13868.6 KOO24063.1 - 0.00074 18.1 104.3 0.00096 17.8 80.4 2.1 1 1 1 2 2 2 2 Trichohyalin-plectin-homology domain Peptidase_M10 PF00413.24 KOO24064.1 - 1.7e-07 31.2 0.0 0.0018 18.1 0.0 3.2 3 0 0 3 3 3 3 Matrixin Reprolysin_5 PF13688.6 KOO24064.1 - 0.009 16.2 0.3 0.1 12.8 0.1 2.3 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 KOO24064.1 - 0.066 12.8 0.7 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 KOO24064.1 - 0.14 10.8 0.2 0.23 10.0 0.2 1.2 1 0 0 1 1 1 0 Putative peptidase family DUF5435 PF17503.2 KOO24064.1 - 0.16 11.7 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5435) Mito_carr PF00153.27 KOO24066.1 - 5.7e-37 125.5 0.1 6.3e-16 58.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein dCMP_cyt_deam_2 PF08211.12 KOO24067.1 - 0.0053 17.0 0.6 0.0085 16.3 0.6 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region TMEM132D_C PF15706.5 KOO24067.1 - 0.03 14.1 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term NTP_transferase PF00483.23 KOO24068.1 - 1.6e-26 93.4 0.0 2.2e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 KOO24068.1 - 3.4e-10 39.2 0.5 3.1e-08 33.0 0.3 2.8 1 1 1 2 2 2 1 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 KOO24068.1 - 7e-05 23.2 0.0 0.00011 22.6 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 KOO24068.1 - 0.00042 19.4 0.0 0.35 9.7 0.0 3.0 2 1 0 2 2 2 2 L-fucokinase Hexapep_2 PF14602.6 KOO24068.1 - 0.0012 18.6 4.2 0.0082 15.9 0.7 3.2 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Ion_trans PF00520.31 KOO24069.1 - 2.9e-187 619.5 62.5 7.4e-53 179.3 6.9 4.1 4 0 0 4 4 4 4 Ion transport protein Ank_2 PF12796.7 KOO24069.1 - 9.6e-24 83.8 1.4 4.1e-07 30.5 0.1 4.0 3 1 1 4 4 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO24069.1 - 3.8e-15 55.8 6.7 0.0056 17.0 0.0 5.6 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO24069.1 - 5.8e-15 55.4 1.0 6.4e-07 29.8 0.1 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO24069.1 - 7.9e-15 54.6 8.0 0.0022 18.3 0.0 6.7 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 KOO24069.1 - 6.6e-14 50.7 8.9 0.16 12.6 0.0 6.6 6 0 0 6 6 6 4 Ankyrin repeat U-box PF04564.15 KOO24069.1 - 6.8e-14 51.8 0.0 1.5e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain GPHH PF16905.5 KOO24069.1 - 4.4e-09 36.0 0.0 1.1e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated K_oxygenase PF13434.6 KOO24069.1 - 0.00021 20.5 0.0 0.0077 15.4 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 KOO24069.1 - 0.0045 17.5 0.0 0.01 16.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase zf-Nse PF11789.8 KOO24069.1 - 0.16 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO24069.1 - 0.16 12.1 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Pyr_redox_3 PF13738.6 KOO24069.1 - 0.24 10.6 0.0 0.41 9.9 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pentapeptide_4 PF13599.6 KOO24070.1 - 5e-39 132.3 0.0 4.6e-05 23.5 0.0 10.9 4 3 9 13 13 13 12 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.18 KOO24070.1 - 5.5e-10 39.4 55.9 0.084 12.7 0.0 18.6 6 3 17 25 25 25 4 Ribosomal protein L13e Ntox33 PF15533.6 KOO24070.1 - 1.8e-06 28.3 18.4 9.2 6.8 0.0 14.2 12 8 5 18 18 18 1 Bacterial toxin 33 Sigma54_CBD PF04963.13 KOO24070.1 - 0.0023 17.8 1.2 15 5.4 0.0 6.2 5 3 3 8 8 8 1 Sigma-54 factor, core binding domain DUF2639 PF11121.8 KOO24070.1 - 0.036 14.1 7.3 38 4.4 0.0 8.8 9 0 0 9 9 9 0 Protein of unknown function (DUF2639) SAP PF02037.27 KOO24070.1 - 0.044 13.5 0.6 26 4.7 0.0 6.6 6 0 0 6 6 6 0 SAP domain MerR_1 PF13411.6 KOO24070.1 - 0.085 13.0 0.1 1.6e+02 2.4 0.0 6.0 5 0 0 5 5 5 0 MerR HTH family regulatory protein Bradykinin PF06753.12 KOO24070.1 - 1.6 8.5 5.3 13 5.6 0.2 4.4 3 0 0 3 3 3 0 Bradykinin DUF5568 PF17724.1 KOO24070.1 - 2.4 7.9 9.9 0.47 10.3 0.7 3.8 4 1 1 5 5 5 0 Family of unknown function (DUF5568) DUF1538 PF07556.11 KOO24073.1 - 1.4e-96 321.8 29.7 3.3e-52 176.9 15.7 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1538) DUF1279 PF06916.13 KOO24074.1 - 1.4e-08 35.1 0.0 2.3e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) MAPEG PF01124.18 KOO24075.1 - 6.3e-14 52.0 0.3 7.9e-14 51.7 0.3 1.2 1 0 0 1 1 1 1 MAPEG family Lipase_GDSL_2 PF13472.6 KOO24076.1 - 6.5e-16 59.2 0.1 9.7e-16 58.7 0.1 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KOO24076.1 - 1e-08 35.4 0.0 3.4e-08 33.7 0.0 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase HATPase_c PF02518.26 KOO24077.1 - 1.7e-06 28.5 0.0 3.8e-06 27.4 0.0 1.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOO24077.1 - 0.017 14.9 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 KOO24077.1 - 0.13 12.3 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Ank_5 PF13857.6 KOO24078.1 - 7.1e-10 39.0 0.0 2.7e-06 27.5 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO24078.1 - 2.6e-09 37.4 0.0 3.6e-06 27.4 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24078.1 - 8.2e-08 31.9 0.0 0.00077 19.7 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 KOO24078.1 - 8.5e-08 32.7 0.0 1e-07 32.4 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO24078.1 - 0.005 17.2 0.3 2.5 8.7 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat WD40 PF00400.32 KOO24079.1 - 2.3e-48 161.2 25.0 1.6e-06 28.7 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Kelch_6 PF13964.6 KOO24079.1 - 7.9e-14 51.4 7.7 1.3 9.4 0.1 7.1 7 0 0 7 7 7 6 Kelch motif Kelch_2 PF07646.15 KOO24079.1 - 3e-10 39.6 5.3 4.5 7.4 0.1 7.1 7 0 0 7 7 7 3 Kelch motif Nup160 PF11715.8 KOO24079.1 - 7.4e-09 34.8 19.4 0.47 9.0 0.3 6.9 2 1 5 7 7 7 6 Nucleoporin Nup120/160 CryBP1 PF07029.11 KOO24079.1 - 0.022 14.9 10.0 11 6.1 0.7 5.2 1 1 6 7 7 7 0 CryBP1 protein Ribosomal_L21e PF01157.18 KOO24079.1 - 0.029 14.2 0.2 14 5.6 0.0 3.7 2 1 2 4 4 4 0 Ribosomal protein L21e BON PF04972.17 KOO24079.1 - 0.038 14.3 8.8 16 5.9 0.1 4.6 4 0 0 4 4 4 0 BON domain DUF5070 PF16802.5 KOO24079.1 - 0.24 11.4 1.8 49 3.9 0.1 3.8 2 1 4 6 6 6 0 Domain of unknown function (DUF5070) DUF2180 PF09947.9 KOO24079.1 - 0.36 10.8 9.7 31 4.6 0.0 5.5 2 1 4 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2180) Syntaxin-6_N PF09177.11 KOO24080.1 - 0.053 14.1 3.8 0.13 12.8 3.8 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal PRKG1_interact PF15898.5 KOO24080.1 - 0.12 13.2 4.3 0.21 12.5 4.3 1.3 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain SOGA PF11365.8 KOO24081.1 - 0.002 19.2 4.3 0.002 19.2 4.3 3.1 1 1 2 3 3 3 1 Protein SOGA DUF1281 PF06924.11 KOO24081.1 - 0.11 12.0 0.1 0.18 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) Allexi_40kDa PF05549.11 KOO24081.1 - 4.5 6.7 9.5 0.41 10.1 2.7 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein Turandot PF07240.11 KOO24083.1 - 0.1 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Stress-inducible humoral factor Turandot Aminotran_4 PF01063.19 KOO24083.1 - 0.18 11.6 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Amino-transferase class IV DSPc PF00782.20 KOO24084.1 - 0.00039 20.2 0.0 0.00053 19.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KOO24084.1 - 0.036 14.0 0.0 0.04 13.9 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 KOO24084.1 - 0.06 12.9 0.0 0.078 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase WD40 PF00400.32 KOO24085.1 - 5.2e-15 55.6 0.8 0.0032 18.3 0.0 5.2 4 1 0 4 4 4 4 WD domain, G-beta repeat PUB PF09409.10 KOO24085.1 - 5.3e-09 35.9 0.0 1.1e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 PUB domain UBA PF00627.31 KOO24085.1 - 2.6e-05 24.0 0.4 6.1e-05 22.8 0.1 1.8 2 0 0 2 2 2 1 UBA/TS-N domain PFU PF09070.11 KOO24085.1 - 8.2e-05 22.8 0.0 0.00014 22.1 0.0 1.2 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) Myb_CC_LHEQLE PF14379.6 KOO24086.1 - 0.00023 20.8 14.4 0.00023 20.8 14.4 2.7 2 1 1 3 3 3 1 MYB-CC type transfactor, LHEQLE motif Myb_DNA-binding PF00249.31 KOO24086.1 - 0.0009 19.4 0.0 0.0018 18.4 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF1269 PF06897.12 KOO24086.1 - 0.19 12.0 1.4 0.31 11.4 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1269) IATP PF04568.12 KOO24086.1 - 1.4 9.4 12.7 2.7 8.5 0.2 3.2 2 1 1 3 3 3 0 Mitochondrial ATPase inhibitor, IATP Asp_Arg_Hydrox PF05118.15 KOO24087.1 - 9.2e-48 162.0 0.0 1.4e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Coatomer_E PF04733.14 KOO24087.1 - 0.091 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Coatomer epsilon subunit TPR_1 PF00515.28 KOO24087.1 - 0.13 12.1 2.5 0.82 9.6 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO24087.1 - 0.24 11.5 1.7 1.7 8.8 0.5 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO24087.1 - 0.33 11.6 20.2 0.12 13.0 6.0 3.2 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO24087.1 - 0.58 9.9 5.8 1 9.1 0.1 3.3 3 0 0 3 3 3 0 TPR repeat TPR_9 PF13371.6 KOO24087.1 - 1.2 9.3 9.9 0.059 13.5 1.9 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO24087.1 - 1.9 9.5 18.6 2.4 9.2 1.6 4.4 1 1 3 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO24087.1 - 3.4 8.3 16.0 6.5 7.4 0.5 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat Adaptin_N PF01602.20 KOO24088.1 - 1.7e-122 409.6 11.7 5e-121 404.8 11.1 1.9 1 1 1 2 2 2 2 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 KOO24088.1 - 9.9e-26 90.2 0.6 2.1e-25 89.2 0.6 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 KOO24088.1 - 1.6e-06 28.2 11.0 0.00033 20.7 5.5 3.0 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KOO24088.1 - 0.0029 18.2 1.6 0.16 12.6 0.2 3.0 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KOO24088.1 - 0.021 15.0 0.3 1.6 9.2 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat HEAT_2 PF13646.6 KOO24088.1 - 0.025 15.0 2.9 0.73 10.3 0.2 3.7 3 0 0 3 3 3 0 HEAT repeats V-ATPase_H_C PF11698.8 KOO24088.1 - 0.034 14.2 0.1 1.2 9.2 0.1 2.9 1 1 0 1 1 1 0 V-ATPase subunit H Head-tail_con PF12236.8 KOO24088.1 - 0.11 11.0 0.0 0.18 10.2 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage head to tail connecting protein DUF3361 PF11841.8 KOO24088.1 - 0.11 12.4 1.8 0.74 9.7 0.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) RICTOR_M PF14666.6 KOO24088.1 - 0.13 12.0 3.5 9.3 6.1 0.1 3.8 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, middle domain DUF5578 PF17741.1 KOO24088.1 - 3.2 7.1 7.8 17 4.8 0.5 3.4 3 1 0 4 4 4 0 Family of unknown function (DUF5578) Syntaxin-6_N PF09177.11 KOO24089.1 - 4.8e-24 84.8 0.9 6.7e-24 84.3 0.9 1.2 1 0 0 1 1 1 1 Syntaxin 6, N-terminal Peptidase_S8 PF00082.22 KOO24090.1 - 0.051 12.8 0.6 0.087 12.1 0.6 1.4 1 0 0 1 1 1 0 Subtilase family TAF8_C PF10406.9 KOO24091.1 - 4.5e-13 49.5 0.7 4.5e-13 49.5 0.7 2.1 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 KOO24091.1 - 3.7e-08 33.3 0.0 6.9e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 KOO24091.1 - 0.18 11.9 0.0 0.32 11.1 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit HemY_N PF07219.13 KOO24091.1 - 0.98 9.7 4.0 0.47 10.7 0.8 2.0 2 0 0 2 2 2 0 HemY protein N-terminus TPT PF03151.16 KOO24092.1 - 1.2e-81 274.2 16.8 1.4e-81 274.0 16.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO24092.1 - 9.4e-12 45.3 28.0 2.8e-07 30.8 7.4 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO24092.1 - 0.00083 18.6 13.4 0.0091 15.2 13.4 2.2 1 1 0 1 1 1 1 UAA transporter family Pkinase PF00069.25 KOO24093.1 - 3.4e-49 167.6 0.0 4e-49 167.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24093.1 - 5.5e-28 97.9 0.0 7.1e-28 97.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO24093.1 - 2.2e-07 30.5 0.0 6.2e-07 29.0 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO24093.1 - 0.00022 20.1 0.0 0.00032 19.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO24093.1 - 0.0052 16.7 0.0 0.01 15.7 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KOO24093.1 - 0.0072 15.7 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOO24093.1 - 0.02 14.5 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 KOO24093.1 - 0.046 12.7 0.0 0.065 12.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain PPR_2 PF13041.6 KOO24094.1 - 2.1e-64 213.5 14.1 7.7e-11 42.0 0.0 9.4 2 1 8 10 10 10 9 PPR repeat family PPR_3 PF13812.6 KOO24094.1 - 2.5e-50 168.4 0.0 5.2e-12 45.7 0.0 6.7 4 2 3 7 7 7 7 Pentatricopeptide repeat domain PPR PF01535.20 KOO24094.1 - 7e-48 157.6 7.4 3.2e-06 27.0 0.0 9.4 9 1 0 9 9 9 9 PPR repeat PPR_1 PF12854.7 KOO24094.1 - 1.4e-29 101.5 9.0 1.1e-05 25.0 0.0 10.2 10 2 0 10 10 10 6 PPR repeat PPR_long PF17177.4 KOO24094.1 - 1.6e-24 86.5 5.0 1e-11 44.6 0.3 4.2 1 1 3 4 4 4 4 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 KOO24094.1 - 0.0053 17.5 7.8 14 6.8 0.0 6.2 5 1 0 6 6 6 0 Tetratricopeptide repeat Urocanase_N PF17391.2 KOO24094.1 - 0.03 14.0 0.7 2.8 7.7 0.1 3.5 2 2 1 4 4 4 0 Urocanase N-terminal domain ThiI PF02568.14 KOO24094.1 - 0.066 12.8 0.2 0.53 9.8 0.1 2.1 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) DUF3322 PF11795.8 KOO24094.1 - 0.08 12.9 4.2 14 5.7 0.1 3.3 2 1 2 4 4 4 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Haem_oxygenas_2 PF14518.6 KOO24094.1 - 0.093 12.5 1.7 11 5.8 0.3 2.6 2 1 0 2 2 2 0 Iron-containing redox enzyme ATP-grasp_4 PF13535.6 KOO24094.1 - 0.13 11.9 0.0 14 5.2 0.0 2.7 1 1 2 3 3 3 0 ATP-grasp domain COX5A PF02284.16 KOO24094.1 - 0.14 12.1 0.1 6.1 6.9 0.0 3.2 1 1 3 5 5 5 0 Cytochrome c oxidase subunit Va Flu_B_NS1 PF02942.14 KOO24094.1 - 0.15 11.1 0.2 34 3.4 0.0 2.9 1 1 1 3 3 3 0 Influenza B non-structural protein (NS1) S1 PF00575.23 KOO24095.1 - 5.6e-35 119.5 0.1 2.9e-10 40.3 0.1 6.9 7 0 0 7 7 7 5 S1 RNA binding domain Suf PF05843.14 KOO24095.1 - 3.1e-10 40.5 0.2 1.4e-06 28.6 0.0 3.2 1 1 2 3 3 3 2 Suppressor of forked protein (Suf) TPR_19 PF14559.6 KOO24095.1 - 0.00082 19.8 0.1 1.8 9.2 0.0 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat NRDE-2 PF08424.10 KOO24095.1 - 0.043 12.9 0.1 0.85 8.7 0.0 2.2 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference TPR_6 PF13174.6 KOO24095.1 - 0.11 13.2 2.9 1.7e+02 3.2 0.0 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ATP-grasp_4 PF13535.6 KOO24099.1 - 1.4e-10 41.0 0.0 2.6e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 KOO24099.1 - 2.9e-10 40.3 0.0 2.5e-07 30.6 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.14 KOO24099.1 - 2.3e-06 27.8 0.0 4.4e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 KOO24099.1 - 0.017 14.7 0.1 0.027 14.0 0.1 1.5 1 1 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.6 KOO24099.1 - 0.025 14.3 0.1 0.2 11.4 0.0 2.4 2 1 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon LAL_C2 PF18603.1 KOO24099.1 - 0.056 13.6 0.1 0.32 11.2 0.1 2.2 2 0 0 2 2 2 0 L-amino acid ligase C-terminal domain 2 Dala_Dala_lig_C PF07478.13 KOO24099.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Nucleotid_trans PF03407.16 KOO24100.1 - 9.8e-08 32.2 0.0 1.5e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF2070 PF09843.9 KOO24101.1 - 0.051 11.9 4.0 0.066 11.5 4.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) EcsB PF05975.12 KOO24101.1 - 0.097 11.5 1.1 0.1 11.5 0.1 1.6 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB DEAD PF00270.29 KOO24102.1 - 9.5e-45 152.5 0.0 6.9e-44 149.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO24102.1 - 2.7e-31 108.2 0.0 5.7e-30 103.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO24102.1 - 6.4e-05 23.0 0.0 0.00021 21.4 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KOO24102.1 - 0.0014 19.0 0.1 1.5 9.1 0.1 2.3 2 0 0 2 2 2 2 AAA domain UTP25 PF06862.12 KOO24102.1 - 0.032 13.0 0.0 3.5 6.3 0.0 2.4 3 0 0 3 3 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 KOO24102.1 - 0.13 11.6 0.1 0.75 9.1 0.0 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Thymidylate_kin PF02223.17 KOO24103.1 - 2.8e-15 56.5 0.0 6.8e-15 55.2 0.0 1.7 1 1 0 1 1 1 1 Thymidylate kinase adh_short_C2 PF13561.6 KOO24104.1 - 7.8e-58 195.8 5.4 8.3e-58 195.7 4.1 1.6 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO24104.1 - 7.5e-56 188.7 6.0 9.2e-56 188.4 6.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOO24104.1 - 6e-17 62.1 1.7 6e-17 62.1 1.7 1.9 2 0 0 2 2 2 1 KR domain Radical_SAM PF04055.21 KOO24104.1 - 0.18 12.2 0.0 0.36 11.2 0.0 1.6 1 0 0 1 1 1 0 Radical SAM superfamily RRM_1 PF00076.22 KOO24105.1 - 0.026 14.3 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bZIP_1 PF00170.21 KOO24106.1 - 0.78 9.9 3.7 0.32 11.1 0.4 1.9 2 0 0 2 2 2 0 bZIP transcription factor DivIC PF04977.15 KOO24106.1 - 0.92 9.3 2.3 1.3 8.9 0.3 2.0 2 0 0 2 2 2 0 Septum formation initiator DUF2076 PF09849.9 KOO24106.1 - 1.7 8.6 13.2 0.9 9.5 10.9 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) LRR_6 PF13516.6 KOO24107.1 - 1.2e-08 34.3 9.1 2.2 8.5 0.1 6.2 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 KOO24107.1 - 0.0026 18.1 2.0 25 5.5 0.1 3.6 3 1 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO24107.1 - 0.011 15.5 0.2 33 4.3 0.0 4.0 4 1 0 4 4 4 0 Leucine rich repeat LRR_1 PF00560.33 KOO24107.1 - 0.058 14.0 0.0 77 4.4 0.0 3.9 4 0 0 4 4 4 0 Leucine Rich Repeat SpoU_sub_bind PF08032.12 KOO24107.1 - 0.069 13.4 0.0 23 5.4 0.0 2.5 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding FAM25 PF15825.5 KOO24107.1 - 0.079 13.3 1.2 2.3 8.6 0.1 2.7 2 0 0 2 2 2 0 FAM25 family Peripla_BP_3 PF13377.6 KOO24107.1 - 0.18 12.1 0.0 81 3.5 0.0 3.0 3 0 0 3 3 3 0 Periplasmic binding protein-like domain HORMA PF02301.18 KOO24108.1 - 1.2e-41 142.6 0.0 1.7e-41 142.2 0.0 1.2 1 0 0 1 1 1 1 HORMA domain HTH_20 PF12840.7 KOO24108.1 - 0.022 14.8 1.3 0.14 12.3 1.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 KOO24108.1 - 0.024 14.6 0.3 0.053 13.5 0.3 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_IclR PF09339.10 KOO24108.1 - 0.056 13.2 0.3 0.13 12.1 0.3 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain MarR_2 PF12802.7 KOO24108.1 - 0.064 13.1 1.8 0.093 12.6 0.3 2.1 2 0 0 2 2 2 0 MarR family RNA_pol_Rpo13 PF12136.8 KOO24108.1 - 0.39 10.7 5.0 1.7 8.6 0.8 2.5 2 0 0 2 2 2 0 RNA polymerase Rpo13 subunit HTH domain EF-hand_1 PF00036.32 KOO24109.1 - 3.3e-07 29.4 2.4 0.004 16.6 0.5 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO24109.1 - 8.1e-06 26.2 0.3 0.046 14.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO24109.1 - 1e-05 25.1 3.0 0.06 13.3 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO24109.1 - 0.00013 21.3 1.9 0.014 14.9 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO24109.1 - 0.00037 20.3 1.0 0.94 9.4 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO24109.1 - 0.028 14.7 0.0 0.51 10.7 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 KOO24109.1 - 0.037 14.0 0.5 3.4 7.7 0.2 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Myb_DNA-bind_7 PF15963.5 KOO24109.1 - 0.21 11.5 0.5 0.61 10.0 0.1 1.9 1 1 1 2 2 2 0 Myb DNA-binding like Glyco_hydro_2_C PF02836.17 KOO24110.1 - 1.8e-93 313.0 0.0 2.3e-93 312.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 KOO24110.1 - 4.7e-05 24.0 0.0 0.00011 22.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 DUF4981 PF16353.5 KOO24110.1 - 0.014 15.9 0.0 0.043 14.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function(DUF4981) DEAD PF00270.29 KOO24111.1 - 3.2e-42 144.3 0.0 7.5e-42 143.1 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO24111.1 - 2e-26 92.5 0.0 1.1e-25 90.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO24111.1 - 0.0017 18.4 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOO24111.1 - 0.012 14.8 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 KOO24111.1 - 0.12 11.7 0.0 0.55 9.5 0.0 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Sel1 PF08238.12 KOO24112.1 - 7.9e-07 29.6 8.0 0.041 14.6 1.2 4.3 3 1 1 4 4 4 2 Sel1 repeat HSP70 PF00012.20 KOO24112.1 - 2.8 6.0 11.9 3.7 5.6 11.9 1.1 1 0 0 1 1 1 0 Hsp70 protein Peptidase_S46 PF10459.9 KOO24112.1 - 3.2 6.3 11.3 4.6 5.8 11.3 1.2 1 0 0 1 1 1 0 Peptidase S46 Myb_DNA-binding PF00249.31 KOO24113.1 - 3.9e-28 97.4 6.0 3.2e-13 49.7 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO24113.1 - 2.3e-22 79.0 4.5 8.8e-17 61.1 0.7 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 KOO24113.1 - 0.0073 16.6 3.0 0.08 13.3 1.0 2.3 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like SLIDE PF09111.10 KOO24113.1 - 0.035 14.1 0.1 4.1 7.5 0.0 2.7 2 1 1 3 3 3 0 SLIDE Myb_DNA-bind_7 PF15963.5 KOO24113.1 - 0.037 13.9 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Myb DNA-binding like SlyX PF04102.12 KOO24113.1 - 0.15 12.7 1.2 0.25 12.0 0.1 2.0 2 0 0 2 2 2 0 SlyX Myb_DNA-bind_2 PF08914.11 KOO24113.1 - 0.19 11.9 0.7 16 5.8 0.3 2.5 1 1 1 2 2 2 0 Rap1 Myb domain Myb_DNA-bind_4 PF13837.6 KOO24113.1 - 1 9.8 3.8 0.8 10.1 0.7 2.2 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain SNF2_N PF00176.23 KOO24114.1 - 1.3e-10 40.6 0.0 1.5e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Alanine_zipper PF11839.8 KOO24114.1 - 0.014 15.7 15.7 0.014 15.7 15.7 4.3 4 1 1 5 5 5 0 Alanine-zipper, major outer membrane lipoprotein Polyketide_cyc2 PF10604.9 KOO24116.1 - 0.00037 20.8 0.0 0.0005 20.4 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Recombinase PF07508.13 KOO24117.1 - 0.0015 18.9 0.0 0.0023 18.3 0.0 1.3 1 0 0 1 1 1 1 Recombinase HTH_32 PF13565.6 KOO24117.1 - 0.16 12.6 0.1 0.52 11.0 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain UbiA PF01040.18 KOO24118.1 - 2.8e-35 121.9 25.7 3.7e-35 121.4 25.7 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family TMEM238 PF15125.6 KOO24118.1 - 0.067 13.4 0.3 0.24 11.6 0.3 1.9 1 0 0 1 1 1 0 TMEM238 protein family DUF2631 PF10939.8 KOO24118.1 - 0.07 13.0 0.4 0.19 11.6 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2631) MIP PF00230.20 KOO24120.1 - 4.3e-29 101.8 13.4 3.5e-27 95.6 13.4 2.1 1 1 0 1 1 1 1 Major intrinsic protein Spermine_synth PF01564.17 KOO24122.1 - 2e-34 118.6 0.0 3.6e-34 117.8 0.0 1.4 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KOO24122.1 - 1.6e-08 34.3 0.2 3.1e-08 33.4 0.2 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 KOO24122.1 - 0.0006 20.5 0.0 0.0011 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO24122.1 - 0.028 14.3 0.0 0.056 13.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOO24122.1 - 0.031 15.0 0.0 0.059 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 KOO24122.1 - 0.064 12.3 0.0 0.095 11.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_24 PF13578.6 KOO24122.1 - 0.16 13.0 0.0 0.3 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain STAS_2 PF13466.6 KOO24123.1 - 0.31 11.4 6.4 0.51 10.7 4.0 2.8 2 0 0 2 2 2 0 STAS domain PITH PF06201.13 KOO24124.1 - 3.8e-35 121.4 0.0 4.8e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 PITH domain Pkinase PF00069.25 KOO24126.1 - 1.2e-71 241.2 0.0 1.5e-71 240.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24126.1 - 1.5e-50 171.9 0.0 1.9e-50 171.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO24126.1 - 8.3e-06 25.3 0.1 0.00091 18.6 0.0 2.3 2 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KOO24126.1 - 3.4e-05 22.8 0.0 5.3e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO24126.1 - 0.00046 20.2 0.0 0.16 11.9 0.0 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO24126.1 - 0.0019 17.2 0.0 0.02 13.9 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain ABC1 PF03109.16 KOO24126.1 - 0.037 14.2 0.0 0.079 13.1 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Kdo PF06293.14 KOO24126.1 - 0.098 12.0 0.0 0.64 9.3 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mob1_phocein PF03637.17 KOO24127.1 - 2.6e-75 252.1 0.1 3.5e-75 251.7 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family DUF1077 PF06417.12 KOO24127.1 - 6.8e-35 119.6 5.5 1.2e-34 118.9 5.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) WD40 PF00400.32 KOO24128.1 - 6.4e-06 26.8 12.2 0.026 15.4 0.3 5.2 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO24128.1 - 0.00044 20.5 0.1 0.37 11.1 0.0 3.6 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 KOO24128.1 - 0.0062 16.4 0.2 0.026 14.4 0.2 2.1 1 0 0 1 1 1 1 PQQ enzyme repeat PQQ_2 PF13360.6 KOO24128.1 - 0.012 15.2 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 PQQ-like domain WD40 PF00400.32 KOO24130.1 - 4.9e-28 96.8 13.2 2.9e-06 27.9 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat PALB2_WD40 PF16756.5 KOO24130.1 - 0.0074 15.2 3.4 0.014 14.4 0.5 2.7 2 1 1 3 3 3 1 Partner and localizer of BRCA2 WD40 domain ANAPC4_WD40 PF12894.7 KOO24130.1 - 0.049 13.9 1.4 45 4.4 0.0 4.4 3 1 2 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_6 PF13405.6 KOO24131.1 - 1.3e-23 80.9 0.4 1.9e-06 27.4 0.1 4.9 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO24131.1 - 6.4e-22 75.4 1.4 6.8e-06 25.3 0.0 4.8 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO24131.1 - 1.9e-18 66.7 1.5 2.7e-08 34.1 0.0 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO24131.1 - 1.3e-17 62.4 5.9 0.00046 19.6 0.1 4.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO24131.1 - 1.6e-12 47.1 4.9 5.9e-05 22.8 0.9 4.7 3 1 1 4 4 4 3 EF-hand domain pair Dockerin_1 PF00404.18 KOO24131.1 - 0.002 18.2 0.3 1.9 8.7 0.0 3.3 4 0 0 4 4 3 1 Dockerin type I domain Rgp1 PF08737.10 KOO24131.1 - 0.025 13.7 2.2 2.6 7.1 0.1 2.1 1 1 0 2 2 2 0 Rgp1 DUF3859 PF12975.7 KOO24131.1 - 0.034 14.1 0.0 0.1 12.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3859) p25-alpha PF05517.12 KOO24131.1 - 0.042 14.0 6.7 0.12 12.5 0.2 2.7 2 1 0 2 2 2 0 p25-alpha DUF5525 PF17663.1 KOO24131.1 - 0.12 10.4 4.6 0.18 9.9 4.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5525) LEM PF03020.15 KOO24131.1 - 0.15 11.6 0.0 2.3 7.9 0.0 2.4 2 0 0 2 2 2 0 LEM domain EF-hand_10 PF14788.6 KOO24131.1 - 0.23 11.4 1.7 39 4.2 0.0 3.4 3 0 0 3 3 3 0 EF hand DUF1840 PF08895.11 KOO24131.1 - 0.42 11.0 7.5 0.11 12.9 1.8 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1840) PG_binding_2 PF08823.11 KOO24131.1 - 1.2 9.5 4.7 1.5 9.2 0.1 3.4 4 1 0 4 4 4 0 Putative peptidoglycan binding domain PQ-loop PF04193.14 KOO24132.1 - 7.6e-07 28.8 0.9 7.6e-07 28.8 0.9 2.0 2 0 0 2 2 2 1 PQ loop repeat MASE3 PF17159.4 KOO24132.1 - 0.067 12.8 5.4 0.075 12.7 5.4 1.1 1 0 0 1 1 1 0 Membrane-associated sensor domain EF-hand_6 PF13405.6 KOO24133.1 - 9.3e-12 43.9 0.2 0.0016 18.2 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO24133.1 - 7.4e-10 37.7 0.0 0.035 13.6 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO24133.1 - 1.2e-09 38.5 0.0 1.3e-07 32.0 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO24133.1 - 1.1e-08 34.2 1.4 0.014 14.8 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO24133.1 - 0.00012 21.8 0.1 1.4 8.8 0.0 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_10 PF14788.6 KOO24133.1 - 0.051 13.4 0.0 3.8 7.5 0.0 2.5 2 1 1 3 3 3 0 EF hand WD40 PF00400.32 KOO24134.1 - 6.3e-31 105.9 14.4 2.5e-05 24.9 0.4 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO24134.1 - 1.6e-05 25.1 0.0 0.58 10.5 0.0 4.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOO24134.1 - 0.011 14.4 0.3 0.9 8.1 0.0 2.9 2 1 1 3 3 3 0 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 KOO24134.1 - 0.1 12.7 0.0 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 KOO24134.1 - 0.22 10.8 0.0 4.9 6.4 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain BRO1 PF03097.18 KOO24135.1 - 1.9e-32 112.6 0.0 2.2e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 BRO1-like domain DEAD PF00270.29 KOO24136.1 - 3.7e-45 153.8 0.0 6.3e-45 153.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO24136.1 - 5.6e-29 100.7 0.1 8.5e-28 96.9 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SRP_SPB PF02978.19 KOO24136.1 - 3e-08 34.2 0.0 6.9e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Signal peptide binding domain ResIII PF04851.15 KOO24136.1 - 5e-06 26.6 0.0 9.5e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 KOO24136.1 - 0.0001 21.7 0.0 0.00028 20.3 0.0 1.7 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit GUCT PF08152.12 KOO24136.1 - 0.00049 20.3 0.0 0.0016 18.7 0.0 1.9 1 0 0 1 1 1 1 GUCT (NUC152) domain Ehrlichia_rpt PF09528.10 KOO24136.1 - 0.024 14.1 0.0 0.054 13.0 0.0 1.5 1 0 0 1 1 1 0 Ehrlichia tandem repeat (Ehrlichia_rpt) Formin_GBD_N PF18382.1 KOO24136.1 - 0.12 12.9 0.7 7.8 7.0 0.0 2.5 2 0 0 2 2 2 0 Formin N-terminal GTPase-binding domain DUF563 PF04577.14 KOO24137.1 - 0.024 14.8 0.0 0.93 9.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF563) FAM184 PF15665.5 KOO24138.1 - 0.059 13.1 2.1 0.11 12.3 2.1 1.4 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Apolipoprotein PF01442.18 KOO24138.1 - 0.2 11.5 10.8 0.12 12.3 8.4 1.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF2130 PF09903.9 KOO24138.1 - 0.23 10.7 0.0 0.32 10.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) Ubiq_cyt_C_chap PF03981.12 KOO24138.1 - 0.41 10.7 3.9 0.34 11.0 1.7 2.0 2 1 0 2 2 2 0 Ubiquinol-cytochrome C chaperone Amino_oxidase PF01593.24 KOO24141.1 - 3.4e-11 43.1 0.0 4.5e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO24141.1 - 8.3e-08 32.4 0.0 2.7e-07 30.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOO24141.1 - 0.00016 21.0 0.1 0.00068 19.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOO24141.1 - 0.0029 16.9 0.1 0.0055 16.0 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 KOO24141.1 - 0.0086 16.6 0.0 0.027 15.0 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO24141.1 - 0.0096 15.5 0.1 0.022 14.3 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 KOO24141.1 - 0.02 14.0 0.1 0.033 13.3 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 KOO24141.1 - 0.066 12.1 0.3 0.1 11.4 0.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 KOO24141.1 - 0.075 12.4 0.2 0.12 11.7 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOO24141.1 - 0.077 12.1 0.5 0.24 10.4 0.0 2.0 3 0 0 3 3 3 0 FAD binding domain FAD_binding_3 PF01494.19 KOO24141.1 - 0.079 12.2 0.1 0.19 10.9 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 KOO24141.1 - 0.079 11.6 0.1 0.11 11.2 0.1 1.1 1 0 0 1 1 1 0 HI0933-like protein 3HCDH_N PF02737.18 KOO24141.1 - 0.16 11.8 0.1 0.25 11.2 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Fer2 PF00111.27 KOO24143.1 - 0.001 19.0 0.8 0.0049 16.8 0.8 2.2 2 1 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain HEPN_SAV2148 PF18725.1 KOO24143.1 - 0.043 13.2 3.0 0.077 12.4 3.0 1.3 1 0 0 1 1 1 0 SAV2148-like HEPN PH_17 PF18012.1 KOO24143.1 - 0.1 12.3 1.2 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 PH domain PH_12 PF16457.5 KOO24143.1 - 0.12 12.9 0.0 1.1 9.8 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain Neisseria_TspB PF05616.13 KOO24143.1 - 9.2 4.6 6.5 13 4.1 6.5 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein ELO PF01151.18 KOO24145.1 - 3.4e-64 216.8 20.1 4.5e-64 216.4 20.1 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Arm PF00514.23 KOO24146.1 - 1.7e-216 694.7 154.6 2.3e-08 33.8 0.0 61.5 64 0 0 64 64 64 45 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO24146.1 - 7.2e-38 128.6 0.1 1.3e-06 28.3 0.0 17.1 19 1 1 20 20 20 5 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO24146.1 - 6.5e-19 68.4 11.5 0.012 15.1 0.0 14.8 12 5 3 16 16 16 4 Armadillo-like V-ATPase_H_N PF03224.14 KOO24146.1 - 1.1e-16 61.1 0.0 0.051 12.8 0.0 11.0 6 5 3 11 11 11 4 V-ATPase subunit H HEAT_2 PF13646.6 KOO24146.1 - 2.4e-15 56.7 169.3 0.16 12.4 0.3 27.4 12 5 19 33 33 33 18 HEAT repeats DUF5578 PF17741.1 KOO24146.1 - 3.8e-11 42.9 32.1 0.013 15.0 0.0 13.4 8 5 3 13 13 13 3 Family of unknown function (DUF5578) Cnd1 PF12717.7 KOO24146.1 - 4.2e-11 43.2 7.8 11 6.0 0.1 12.1 11 3 3 14 14 14 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KOO24146.1 - 3.2e-10 39.2 18.8 0.34 9.4 0.0 11.2 10 3 1 11 11 11 5 Adaptin N terminal region V-ATPase_H_C PF11698.8 KOO24146.1 - 2.6e-08 34.0 0.8 22 5.2 0.1 10.4 11 0 0 11 11 11 0 V-ATPase subunit H HEAT_EZ PF13513.6 KOO24146.1 - 8.1e-06 26.2 127.2 0.038 14.5 0.7 27.5 30 2 3 33 33 33 8 HEAT-like repeat EXOSC1 PF10447.9 KOO24147.1 - 3e-08 34.2 0.1 0.002 18.7 0.0 2.5 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 KOO24147.1 - 0.0015 18.3 0.2 0.0069 16.2 0.0 2.2 2 1 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region TauD PF02668.16 KOO24148.1 - 3.6e-37 128.6 0.1 4.7e-37 128.2 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Roc PF08477.13 KOO24150.1 - 1.7e-11 44.4 0.0 2.4e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO24150.1 - 2.4e-08 33.7 0.0 3.2e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Arf PF00025.21 KOO24150.1 - 0.00047 19.7 0.0 0.00074 19.0 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOO24150.1 - 0.011 15.1 0.0 0.024 14.0 0.0 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA PF00004.29 KOO24150.1 - 0.093 13.1 0.0 0.11 12.9 0.0 1.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Tropomyosin_1 PF12718.7 KOO24151.1 - 0.028 14.6 1.0 0.043 14.0 1.0 1.2 1 0 0 1 1 1 0 Tropomyosin like COG6 PF06419.11 KOO24151.1 - 0.068 11.4 0.6 0.11 10.6 0.6 1.2 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 CCDC53 PF10152.9 KOO24151.1 - 0.24 11.8 2.4 11 6.5 0.1 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex TMF_TATA_bd PF12325.8 KOO24151.1 - 0.4 10.9 2.4 0.73 10.1 2.4 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding MbeD_MobD PF04899.12 KOO24151.1 - 0.66 10.1 7.2 0.28 11.3 4.4 1.8 2 0 0 2 2 2 0 MbeD/MobD like IQ PF00612.27 KOO24152.1 - 1e-05 24.9 9.4 0.045 13.6 0.6 3.7 3 0 0 3 3 3 2 IQ calmodulin-binding motif cNMP_binding PF00027.29 KOO24153.1 - 1.1e-54 182.4 1.3 6.5e-19 67.8 0.0 5.4 5 0 0 5 5 5 5 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 KOO24153.1 - 0.025 14.3 3.2 0.13 11.9 0.2 3.1 3 0 0 3 3 3 0 Cupin domain DUF4846 PF16138.5 KOO24153.1 - 0.098 12.1 0.0 10 5.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (4846) R2K_3 PF14243.6 KOO24153.1 - 0.12 12.4 0.1 0.31 11.0 0.0 1.7 2 0 0 2 2 2 0 ATP-grasp domain, R2K clade family 3 U-box PF04564.15 KOO24154.1 - 4e-11 42.9 0.0 8.6e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO24154.1 - 1.2e-10 41.6 7.0 0.00035 21.1 0.2 3.6 3 0 0 3 3 3 3 Sel1 repeat zf-Nse PF11789.8 KOO24154.1 - 0.00024 20.8 0.0 0.00059 19.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO24154.1 - 0.011 15.9 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein MKLP1_Arf_bdg PF16540.5 KOO24154.1 - 0.067 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Arf6-interacting domain of mitotic kinesin-like protein 1 Chloroa_b-bind PF00504.21 KOO24155.1 - 5.9e-30 104.9 0.5 7.8e-30 104.5 0.5 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Robl_LC7 PF03259.17 KOO24156.1 - 9.6e-09 34.9 1.4 1.1e-08 34.7 0.0 1.8 2 0 0 2 2 2 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 KOO24156.1 - 0.0019 18.1 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 Arm PF00514.23 KOO24158.1 - 2.3e-15 56.0 25.7 0.015 15.4 0.0 10.5 11 0 0 11 11 11 7 Armadillo/beta-catenin-like repeat AAA_13 PF13166.6 KOO24158.1 - 3 6.4 5.6 5.5 5.5 5.6 1.3 1 0 0 1 1 1 0 AAA domain Kinesin PF00225.23 KOO24160.1 - 4.8e-102 341.3 0.0 5.8e-102 341.0 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO24160.1 - 7e-21 74.7 0.0 1.9e-20 73.3 0.0 1.8 1 1 0 1 1 1 1 Microtubule binding UQ_con PF00179.26 KOO24162.1 - 9.6e-27 93.3 0.0 1.3e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO24162.1 - 0.00014 21.6 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 KOO24162.1 - 0.027 14.1 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 KOO24162.1 - 0.051 13.9 0.0 0.069 13.4 0.0 1.4 1 0 0 1 1 1 0 RWD domain WD40 PF00400.32 KOO24163.1 - 9.7e-13 48.4 2.6 0.0052 17.6 0.0 4.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO24163.1 - 3.5e-05 24.0 0.0 0.58 10.5 0.0 3.5 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 KOO24163.1 - 0.45 9.4 2.8 0.89 8.4 0.2 2.0 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Raptor_N PF14538.6 KOO24165.1 - 4e-55 185.8 0.0 5.4e-55 185.4 0.0 1.1 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain DnaI_N PF07319.11 KOO24167.1 - 0.018 15.7 1.1 0.036 14.7 1.1 1.6 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus RB_A PF01858.17 KOO24167.1 - 0.042 13.7 1.1 0.044 13.6 1.1 1.1 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain HMG_box_5 PF14887.6 KOO24167.1 - 0.055 13.4 4.9 0.13 12.2 4.9 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box 5 Peptidase_M74 PF03411.13 KOO24167.1 - 0.14 11.7 3.4 0.33 10.5 0.0 2.2 1 1 0 2 2 2 0 Penicillin-insensitive murein endopeptidase DDE_Tnp_4 PF13359.6 KOO24167.1 - 0.34 10.6 2.5 0.51 10.0 0.3 2.0 1 1 1 2 2 2 0 DDE superfamily endonuclease BRD4_CDT PF17105.5 KOO24168.1 - 7.6 6.2 8.6 0.65 9.7 3.1 2.1 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 UPF0020 PF01170.18 KOO24169.1 - 2.9e-10 40.2 0.0 9.5e-10 38.5 0.0 1.8 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 KOO24169.1 - 0.00099 18.9 0.0 0.039 13.6 0.0 2.2 2 0 0 2 2 2 1 DNA methylase N6_Mtase PF02384.16 KOO24169.1 - 0.0087 15.4 0.0 0.13 11.5 0.0 2.0 2 0 0 2 2 2 1 N-6 DNA Methylase SNN_transmemb PF09049.10 KOO24169.1 - 0.19 11.7 1.2 0.52 10.3 1.2 1.8 1 0 0 1 1 1 0 Stannin transmembrane FMN_bind_2 PF04299.12 KOO24171.1 - 0.036 13.8 0.0 0.048 13.4 0.0 1.2 1 0 0 1 1 1 0 Putative FMN-binding domain EF-hand_1 PF00036.32 KOO24172.1 - 1.3e-31 105.7 12.1 0.00072 18.9 0.2 7.4 7 0 0 7 7 7 6 EF hand EF-hand_6 PF13405.6 KOO24172.1 - 8.8e-29 97.0 8.4 0.00028 20.6 0.1 7.5 7 0 0 7 7 7 6 EF-hand domain EF-hand_7 PF13499.6 KOO24172.1 - 6.7e-26 90.5 5.7 2.3e-08 34.4 0.4 5.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO24172.1 - 6.6e-18 63.3 13.5 0.00018 20.8 0.1 7.5 7 0 0 7 7 7 5 EF hand EF-hand_8 PF13833.6 KOO24172.1 - 1.3e-11 44.1 10.1 0.00018 21.3 0.2 5.7 4 2 2 6 6 6 3 EF-hand domain pair EF-hand_4 PF12763.7 KOO24172.1 - 0.0032 17.4 5.8 3.2 7.8 0.0 4.9 4 1 1 5 5 5 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO24172.1 - 0.0073 16.6 0.2 0.43 10.9 0.1 3.5 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Mg_trans_NIPA PF05653.14 KOO24174.1 - 1.3e-14 54.0 16.4 7.3e-14 51.6 16.4 2.0 1 1 0 1 1 1 1 Magnesium transporter NIPA DnaJ PF00226.31 KOO24175.1 - 5.4e-20 71.3 0.7 1.1e-19 70.3 0.7 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 KOO24175.1 - 2.9e-12 45.7 32.1 0.0051 16.8 0.3 7.6 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOO24175.1 - 1.5e-10 40.4 24.3 0.0093 15.8 0.4 7.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO24175.1 - 1e-09 38.8 32.6 0.013 15.9 0.0 6.3 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO24175.1 - 2.4e-07 31.3 59.3 0.00025 21.6 13.4 8.2 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_9 PF13371.6 KOO24175.1 - 0.00022 21.3 7.6 0.00022 21.3 7.6 5.0 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO24175.1 - 0.00042 20.5 39.5 0.0082 16.4 0.1 7.1 6 2 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO24175.1 - 0.024 14.9 11.7 0.059 13.6 0.0 4.5 4 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KOO24175.1 - 1.4 9.1 17.2 10 6.4 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO24175.1 - 9.6 6.0 9.9 3.8 7.3 1.0 4.0 5 0 0 5 5 5 0 TPR repeat Sulfate_transp PF00916.20 KOO24176.1 - 1.1e-65 221.9 20.8 1.5e-37 129.2 11.5 2.2 2 0 0 2 2 2 2 Sulfate permease family FA_desaturase PF00487.24 KOO24176.1 - 7.1e-26 91.6 14.2 7.1e-26 91.6 14.2 2.7 3 0 0 3 3 3 1 Fatty acid desaturase STAS PF01740.21 KOO24176.1 - 7.9e-11 41.6 0.0 1.5e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 STAS domain Cyt-b5 PF00173.28 KOO24176.1 - 1.3e-05 25.3 0.0 3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MFS_MOT1 PF16983.5 KOO24176.1 - 0.23 11.8 10.2 0.028 14.8 4.1 2.6 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily PI3_PI4_kinase PF00454.27 KOO24177.1 - 7.9e-41 140.5 0.0 1.4e-40 139.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase NUC194 PF08163.12 KOO24177.1 - 4.6e-13 48.9 0.0 1.1e-06 27.8 0.0 2.7 2 1 0 2 2 2 2 NUC194 domain R3H PF01424.22 KOO24177.1 - 1.1e-10 41.3 0.3 2.7e-10 40.1 0.3 1.7 1 0 0 1 1 1 1 R3H domain FAT PF02259.23 KOO24177.1 - 8.1e-09 35.1 0.0 2.7e-08 33.4 0.0 1.8 2 0 0 2 2 2 1 FAT domain Aldo_ket_red PF00248.21 KOO24178.1 - 8.8e-17 61.2 0.0 1.4e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Abhydrolase_2 PF02230.16 KOO24178.1 - 4.2e-08 33.3 0.0 8e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 KOO24178.1 - 0.0012 18.1 0.0 1.6 7.9 0.0 2.6 2 0 0 2 2 2 2 Serine aminopeptidase, S33 PALP PF00291.25 KOO24179.1 - 6.2e-34 117.8 1.6 6.9e-34 117.6 1.6 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Ank_4 PF13637.6 KOO24180.1 - 4.8e-11 43.0 0.0 1.3e-10 41.6 0.0 1.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO24180.1 - 3.6e-10 39.9 0.1 6.9e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) PX PF00787.24 KOO24180.1 - 1.1e-09 38.2 0.0 1.7e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 PX domain Ank_2 PF12796.7 KOO24180.1 - 9.5e-09 35.7 0.0 1.6e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO24180.1 - 4.4e-08 33.2 0.2 3.5e-07 30.4 0.2 2.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 KOO24180.1 - 1.7e-06 27.9 0.1 3.6e-05 23.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat EF-hand_1 PF00036.32 KOO24181.1 - 8.7e-17 59.3 7.8 2.2e-05 23.7 0.3 4.8 4 1 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO24181.1 - 2.1e-15 56.9 2.7 1.2e-07 32.1 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO24181.1 - 2e-14 52.2 9.0 0.00079 19.2 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO24181.1 - 1.7e-08 33.6 7.8 0.0009 18.6 0.3 4.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO24181.1 - 2.5e-08 33.6 5.7 7.4e-07 28.9 0.1 3.6 2 2 1 3 3 3 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO24181.1 - 0.0002 21.6 0.0 0.84 10.0 0.0 2.5 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO24181.1 - 0.0042 17.0 0.5 0.018 15.0 0.1 2.2 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand S_100 PF01023.19 KOO24181.1 - 0.0049 16.5 0.2 0.063 13.0 0.0 2.9 3 0 0 3 3 3 1 S-100/ICaBP type calcium binding domain EF-hand_9 PF14658.6 KOO24181.1 - 0.046 14.1 0.4 4.8 7.6 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain MBD PF01429.19 KOO24182.1 - 5.7e-07 29.1 0.0 2.4e-06 27.1 0.0 2.1 1 0 0 1 1 1 1 Methyl-CpG binding domain AP2 PF00847.20 KOO24182.1 - 7.3e-05 22.9 11.6 0.6 10.4 0.0 4.9 4 0 0 4 4 4 3 AP2 domain T2SS-T3SS_pil_N PF13629.6 KOO24182.1 - 0.035 13.9 0.0 0.087 12.6 0.0 1.6 1 0 0 1 1 1 0 Pilus formation protein N terminal region E1-E2_ATPase PF00122.20 KOO24184.1 - 1.7e-17 63.5 2.3 7.8e-14 51.6 0.0 2.7 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase PF00702.26 KOO24184.1 - 1.8e-11 44.7 13.5 1.9e-10 41.4 7.7 3.7 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOO24184.1 - 0.021 14.5 0.0 0.06 13.0 0.0 1.8 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOO24184.1 - 0.21 11.3 0.0 0.37 10.5 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Sec23_helical PF04815.15 KOO24185.1 - 3.7e-16 58.8 0.0 7.9e-16 57.8 0.0 1.6 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KOO24185.1 - 1e-06 29.4 0.0 1.6e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 KOO24185.1 - 0.11 12.4 0.0 0.56 10.1 0.0 2.0 1 1 0 1 1 1 0 Gelsolin repeat BTV_NS2 PF04514.12 KOO24186.1 - 0.038 12.8 0.0 0.06 12.2 0.0 1.3 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Exostosin PF03016.15 KOO24188.1 - 5.3e-09 35.7 0.0 7.5e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Exostosin family 2OG-FeII_Oxy_3 PF13640.6 KOO24189.1 - 0.024 15.5 0.0 0.045 14.6 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Phage_GP20 PF06810.11 KOO24190.1 - 1 9.1 35.3 1 9.2 0.6 5.3 2 2 4 6 6 6 0 Phage minor structural protein GP20 MBT PF02820.18 KOO24191.1 - 0.0014 18.9 0.1 0.0028 18.0 0.1 1.4 1 0 0 1 1 1 1 mbt repeat Agenet PF05641.12 KOO24191.1 - 0.011 16.2 0.2 0.022 15.2 0.2 1.5 1 0 0 1 1 1 0 Agenet domain Tudor-knot PF11717.8 KOO24191.1 - 0.03 14.2 0.1 0.062 13.2 0.1 1.5 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain AAA PF00004.29 KOO24192.1 - 3.2e-16 60.0 0.0 5.3e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 KOO24192.1 - 2.2e-15 56.8 0.0 7.8e-15 55.1 0.0 1.9 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 KOO24192.1 - 7.1e-12 45.4 0.0 4.5e-10 39.5 0.1 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 KOO24192.1 - 1e-07 32.1 0.0 4.8e-07 29.9 0.0 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 KOO24192.1 - 3.6e-05 24.0 0.5 0.37 11.0 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.6 KOO24192.1 - 7e-05 23.3 0.0 0.0002 21.8 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 KOO24192.1 - 0.00029 20.7 0.1 0.0007 19.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KOO24192.1 - 0.00037 20.3 0.0 0.0013 18.5 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 KOO24192.1 - 0.00047 19.4 0.0 0.00075 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 KOO24192.1 - 0.00063 19.8 0.0 0.001 19.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO24192.1 - 0.00082 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO24192.1 - 0.002 18.5 0.2 0.05 13.9 0.1 2.4 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 KOO24192.1 - 0.0022 18.0 0.0 0.006 16.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 KOO24192.1 - 0.0064 16.4 0.0 0.009 16.0 0.0 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 KOO24192.1 - 0.0066 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 KOO24192.1 - 0.0084 15.9 0.0 0.019 14.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KOO24192.1 - 0.024 14.2 0.1 0.12 11.9 0.1 2.1 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 KOO24192.1 - 0.029 14.1 0.2 0.57 9.9 0.0 2.6 2 1 1 3 3 3 0 DEAD/DEAH box helicase TniB PF05621.11 KOO24192.1 - 0.055 12.9 0.0 0.75 9.2 0.0 2.2 1 1 1 2 2 2 0 Bacterial TniB protein IstB_IS21 PF01695.17 KOO24192.1 - 0.062 13.0 0.0 0.17 11.6 0.0 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein SNF2_N PF00176.23 KOO24192.1 - 0.066 11.9 0.0 5.7 5.5 0.0 2.2 2 0 0 2 2 2 0 SNF2 family N-terminal domain AAA_3 PF07726.11 KOO24192.1 - 0.093 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KOO24192.1 - 0.13 11.6 0.1 0.27 10.6 0.1 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 KOO24192.1 - 0.15 11.5 0.2 2.6 7.5 0.0 2.2 1 1 0 2 2 2 0 PhoH-like protein DUF1348 PF07080.11 KOO24193.1 - 0.12 12.2 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1348) EGF_CA PF07645.15 KOO24194.1 - 2.5e-13 50.0 22.3 5.4e-09 36.1 5.4 3.3 3 0 0 3 3 3 2 Calcium-binding EGF domain Arm PF00514.23 KOO24194.1 - 1.9e-08 34.0 2.1 0.005 16.8 0.7 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat EGF_3 PF12947.7 KOO24194.1 - 0.00022 21.4 23.6 0.0088 16.2 3.6 3.4 3 0 0 3 3 3 2 EGF domain DUF4215 PF13948.6 KOO24194.1 - 0.003 17.9 1.9 0.003 17.9 1.9 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4215) Alkyl_sulf_dimr PF14863.6 KOO24194.1 - 0.12 12.8 2.4 0.34 11.4 2.4 1.8 1 1 0 1 1 1 0 Alkyl sulfatase dimerisation Atx10homo_assoc PF09759.9 KOO24194.1 - 0.12 12.4 0.0 2.1 8.4 0.1 2.3 1 1 1 2 2 2 0 Spinocerebellar ataxia type 10 protein domain EGF PF00008.27 KOO24194.1 - 0.23 11.8 18.7 0.73 10.2 6.9 2.9 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 KOO24194.1 - 0.41 11.4 19.7 0.36 11.5 6.9 3.4 2 1 1 3 3 3 0 Human growth factor-like EGF cEGF PF12662.7 KOO24194.1 - 6.2 6.9 12.8 8 6.5 0.0 4.5 4 0 0 4 4 4 0 Complement Clr-like EGF-like TIG PF01833.24 KOO24195.1 - 9.4e-45 150.6 28.7 9.8e-11 41.6 0.1 6.0 5 0 0 5 5 5 5 IPT/TIG domain G8 PF10162.9 KOO24195.1 - 9e-26 90.4 0.0 2.7e-25 88.8 0.0 1.9 1 0 0 1 1 1 1 G8 domain Beta_helix PF13229.6 KOO24195.1 - 4.1e-08 33.2 6.7 0.00069 19.5 3.5 3.1 2 1 0 2 2 2 2 Right handed beta helix region F5_F8_type_C PF00754.25 KOO24195.1 - 0.00021 21.4 0.0 0.00054 20.1 0.0 1.6 1 0 0 1 1 1 1 F5/8 type C domain MarR_2 PF12802.7 KOO24196.1 - 0.52 10.2 3.1 0.21 11.5 0.5 1.7 2 0 0 2 2 2 0 MarR family CS PF04969.16 KOO24197.1 - 0.00058 20.8 0.2 0.001 20.1 0.2 1.3 1 0 0 1 1 1 1 CS domain DUF995 PF06191.12 KOO24197.1 - 0.13 11.9 0.0 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF995) zf-MYND PF01753.18 KOO24198.1 - 3.7e-07 30.1 8.7 3.7e-07 30.1 8.7 1.7 2 0 0 2 2 2 1 MYND finger TPR_14 PF13428.6 KOO24198.1 - 0.21 12.5 4.1 2.2 9.4 0.2 3.6 2 0 0 2 2 2 0 Tetratricopeptide repeat peroxidase PF00141.23 KOO24199.1 - 1.1e-35 123.4 0.0 2.2e-35 122.4 0.0 1.5 1 1 0 1 1 1 1 Peroxidase NAD_binding_1 PF00175.21 KOO24199.1 - 1.3e-19 70.8 0.0 2.4e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOO24199.1 - 4.1e-11 43.1 0.0 6.9e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain EF-hand_1 PF00036.32 KOO24200.1 - 3e-39 129.6 12.6 3.2e-05 23.2 0.1 7.8 7 0 0 7 7 7 7 EF hand EF-hand_7 PF13499.6 KOO24200.1 - 2.1e-31 108.1 11.9 6.2e-10 39.4 0.3 4.9 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO24200.1 - 7.6e-31 103.4 24.2 0.0011 18.7 0.1 8.8 9 0 0 9 9 9 7 EF-hand domain EF-hand_8 PF13833.6 KOO24200.1 - 1.2e-24 85.9 16.4 9.7e-08 31.7 0.3 6.4 4 3 3 7 7 7 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO24200.1 - 3.4e-24 83.2 10.2 0.0057 16.1 0.1 7.4 7 0 0 7 7 7 6 EF hand EF-hand_4 PF12763.7 KOO24200.1 - 1.6e-08 34.4 4.1 0.33 10.9 0.1 5.6 4 2 2 6 6 6 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO24200.1 - 6.1e-08 32.9 0.9 0.0069 16.7 0.1 4.3 4 0 0 4 4 4 1 EF-hand domain EF-hand_10 PF14788.6 KOO24200.1 - 2.7e-05 23.9 5.5 0.016 15.1 0.1 4.9 3 2 2 5 5 5 1 EF hand p25-alpha PF05517.12 KOO24200.1 - 0.0012 19.1 3.6 0.17 12.0 0.2 3.7 4 1 0 4 4 4 1 p25-alpha CopG_antitoxin PF12441.8 KOO24200.1 - 0.018 15.6 0.6 0.53 10.9 0.1 2.6 2 0 0 2 2 2 0 CopG antitoxin of type II toxin-antitoxin system EF-hand_11 PF08976.11 KOO24200.1 - 0.031 15.1 0.8 7.4 7.5 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO24200.1 - 0.041 14.2 0.9 5.9 7.2 0.0 3.4 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 KOO24200.1 - 0.075 11.6 0.0 1 7.9 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5580) SRP68 PF16969.5 KOO24201.1 - 2.4e-121 406.5 0.0 2.8e-121 406.3 0.0 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 VCBS PF13517.6 KOO24201.1 - 1.3e-115 378.0 147.2 2e-13 50.7 6.2 13.4 2 2 11 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO24201.1 - 9.7e-58 191.9 151.7 6.1e-05 23.1 3.3 14.6 14 0 0 14 14 14 14 FG-GAP repeat Dockerin_1 PF00404.18 KOO24201.1 - 6e-11 42.4 48.1 1.8 8.8 0.3 13.9 13 1 1 14 14 14 5 Dockerin type I domain TM_PBP2_N PF16296.5 KOO24201.1 - 0.0038 17.3 0.0 32 4.7 0.0 5.9 7 0 0 7 7 7 0 N-terminal of TM subunit in PBP-dependent ABC transporters HycA_repressor PF11046.8 KOO24201.1 - 5.1 7.3 6.3 19 5.4 0.0 5.2 7 0 0 7 7 7 0 Transcriptional repressor of hyc and hyp operons Ion_trans PF00520.31 KOO24202.1 - 4.1e-35 121.2 17.9 5e-35 120.9 17.9 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO24202.1 - 0.0022 16.7 4.6 0.0022 16.7 4.6 2.5 2 1 1 3 3 3 2 Polycystin cation channel ABC1 PF03109.16 KOO24203.1 - 0.0034 17.5 0.0 0.0063 16.7 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO24203.1 - 0.03 14.3 1.7 0.031 14.2 0.4 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 KOO24203.1 - 0.055 13.1 0.0 0.17 11.5 0.0 1.7 2 0 0 2 2 2 0 RIO1 family WD40 PF00400.32 KOO24204.1 - 3.1e-19 69.0 26.3 0.0043 17.8 0.0 11.1 12 0 0 12 12 12 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO24204.1 - 7.4e-08 32.6 0.2 3.9 7.8 0.0 6.0 5 2 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 KOO24204.1 - 0.00034 20.4 0.2 0.071 13.1 0.0 3.3 3 0 0 3 3 3 1 PQQ enzyme repeat PQQ_3 PF13570.6 KOO24204.1 - 0.00093 19.6 6.9 0.14 12.7 0.2 4.6 5 0 0 5 5 5 2 PQQ-like domain PQQ_2 PF13360.6 KOO24204.1 - 0.0017 17.9 0.4 0.93 9.0 0.0 3.5 4 0 0 4 4 4 1 PQQ-like domain Nup160 PF11715.8 KOO24204.1 - 0.0049 15.6 0.1 0.055 12.1 0.0 2.1 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 KOO24204.1 - 0.0059 15.2 0.0 0.15 10.6 0.0 2.8 3 1 0 3 3 3 1 Cytochrome D1 heme domain Hira PF07569.11 KOO24204.1 - 0.007 16.1 0.4 0.27 10.9 0.0 2.7 2 0 0 2 2 2 1 TUP1-like enhancer of split zf-C2H2 PF00096.26 KOO24205.1 - 6.9e-30 101.8 52.0 2.2e-05 24.6 1.4 6.6 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO24205.1 - 2.4e-23 81.4 47.3 4.7e-06 26.8 0.5 7.1 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO24205.1 - 1.5e-17 62.7 43.0 0.0097 16.7 0.8 7.0 6 0 0 6 6 6 6 C2H2-type zinc finger IQ PF00612.27 KOO24205.1 - 0.025 14.4 3.9 0.77 9.7 0.1 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif zf-C2H2_8 PF15909.5 KOO24205.1 - 0.052 13.9 18.1 1.6 9.1 6.8 3.0 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-met PF12874.7 KOO24205.1 - 0.11 13.0 11.7 4.1 7.9 0.2 4.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type CHORD PF04968.12 KOO24205.1 - 4.7 8.0 33.4 12 6.7 0.6 6.6 1 1 5 6 6 6 0 CHORD DUF1398 PF07166.11 KOO24205.1 - 5.4 7.1 5.8 63 3.7 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1398) SBBP PF06739.11 KOO24205.1 - 9.3 6.3 33.8 0.98 9.5 4.1 4.9 5 0 0 5 5 5 0 Beta-propeller repeat TRI9 PF08195.11 KOO24206.1 - 0.0045 16.9 3.3 0.8 9.6 0.2 3.2 3 1 1 4 4 4 2 TRI9 protein Luteo_PO PF04662.13 KOO24206.1 - 0.12 12.0 1.2 28 4.3 0.0 3.2 1 1 3 4 4 4 0 Luteovirus P0 protein SET PF00856.28 KOO24207.1 - 2.8e-10 40.8 0.0 1.4e-09 38.6 0.0 1.9 1 1 0 1 1 1 1 SET domain DUF3665 PF12427.8 KOO24207.1 - 0.057 13.1 0.0 0.44 10.3 0.0 2.3 2 0 0 2 2 2 0 Branched-chain amino acid aminotransferase NmrA PF05368.13 KOO24208.1 - 7.4e-24 84.6 0.7 9.3e-24 84.3 0.7 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 KOO24208.1 - 1.7e-12 47.6 0.1 2.8e-12 46.9 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOO24208.1 - 0.0085 15.6 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Voltage_CLC PF00654.20 KOO24209.1 - 4.5e-48 164.3 37.9 7e-33 114.3 21.3 2.6 3 0 0 3 3 3 2 Voltage gated chloride channel Cyclin_N PF00134.23 KOO24210.1 - 1e-47 161.1 1.6 6.7e-47 158.4 0.2 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOO24210.1 - 5.4e-32 110.4 0.3 9.5e-32 109.6 0.3 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain AbiJ_NTD5 PF18865.1 KOO24210.1 - 0.033 14.0 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 AbiJ N-terminal domain 5 Ndc80_HEC PF03801.13 KOO24210.1 - 0.037 13.6 0.0 0.087 12.4 0.0 1.6 1 0 0 1 1 1 0 HEC/Ndc80p family Cupin_8 PF13621.6 KOO24212.1 - 2.6e-15 56.9 0.1 4e-15 56.2 0.1 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO24212.1 - 1e-05 25.2 0.0 1.3e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein ATG27 PF09451.10 KOO24213.1 - 2.5e-08 34.1 0.2 2.3e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 KOO24213.1 - 1e-07 31.4 0.0 1.5e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor KCNQC3-Ank-G_bd PF11956.8 KOO24213.1 - 0.094 13.0 0.1 0.19 12.1 0.1 1.6 1 0 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 Ion_trans PF00520.31 KOO24214.1 - 6.2e-11 42.0 6.5 7.8e-11 41.7 6.5 1.1 1 0 0 1 1 1 1 Ion transport protein EF-hand_5 PF13202.6 KOO24214.1 - 5.4e-06 25.6 0.6 1.1e-05 24.7 0.6 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO24214.1 - 1.7e-05 24.0 0.3 3.2e-05 23.1 0.3 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO24214.1 - 2.5e-05 23.8 0.1 5.3e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO24214.1 - 0.00011 22.6 0.0 0.00014 22.2 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO24214.1 - 0.0093 15.8 0.1 0.017 14.9 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair DUF2663 PF10864.8 KOO24214.1 - 0.016 15.6 1.0 0.028 14.8 0.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2663) PEMT PF04191.13 KOO24214.1 - 0.16 12.3 3.5 0.42 11.0 3.5 1.7 1 1 0 1 1 1 0 Phospholipid methyltransferase COX4_pro_2 PF07835.12 KOO24214.1 - 1.2 9.2 6.1 3 8.0 1.5 2.4 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV Ion_trans PF00520.31 KOO24215.1 - 1.8e-26 92.9 22.3 2.2e-26 92.6 22.3 1.1 1 0 0 1 1 1 1 Ion transport protein ThrE PF06738.12 KOO24216.1 - 1e-19 70.9 1.4 1.9e-19 70.0 1.4 1.5 1 0 0 1 1 1 1 Putative threonine/serine exporter Rieske PF00355.26 KOO24216.1 - 2.9e-09 36.8 0.0 5.5e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 KOO24216.1 - 1.7e-06 27.9 0.0 3.3e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain 2OG-FeII_Oxy_2 PF13532.6 KOO24217.1 - 4.6e-18 66.1 0.0 1.4e-17 64.6 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Mg_trans_NIPA PF05653.14 KOO24217.1 - 7.4e-10 38.4 5.4 7.4e-10 38.4 5.4 1.6 2 0 0 2 2 2 1 Magnesium transporter NIPA EamA PF00892.20 KOO24217.1 - 0.96 9.6 18.1 0.067 13.4 5.3 3.2 3 0 0 3 3 3 0 EamA-like transporter family zf-LSD1 PF06943.12 KOO24217.1 - 1.5 8.8 4.2 4.7 7.1 0.6 2.6 2 0 0 2 2 2 0 LSD1 zinc finger Fructosamin_kin PF03881.14 KOO24218.1 - 7.6e-72 241.9 0.0 9.1e-72 241.7 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 KOO24218.1 - 3.8e-12 46.7 0.1 5.1e-12 46.2 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RSN1_7TM PF02714.15 KOO24219.1 - 2.8e-17 62.9 6.1 5.1e-17 62.1 6.1 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate Anoctamin PF04547.12 KOO24219.1 - 1.7e-07 30.5 0.2 3.2e-07 29.6 0.2 1.4 1 0 0 1 1 1 1 Calcium-activated chloride channel PHM7_cyt PF14703.6 KOO24219.1 - 1.2e-05 25.6 3.4 0.086 13.1 0.1 2.3 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter Herpes_UL20 PF04544.12 KOO24219.1 - 0.0052 17.2 0.1 0.017 15.5 0.1 1.8 1 0 0 1 1 1 1 Herpesvirus egress protein UL20 DUF998 PF06197.13 KOO24219.1 - 0.36 10.4 6.6 3.4 7.2 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF998) Got1 PF04178.12 KOO24220.1 - 6.3e-27 94.2 13.1 1.1e-26 93.4 11.8 1.9 1 1 1 2 2 2 2 Got1/Sft2-like family SLAC1 PF03595.17 KOO24220.1 - 0.023 14.0 9.4 0.31 10.3 5.9 2.0 1 1 1 2 2 2 0 Voltage-dependent anion channel EamA PF00892.20 KOO24220.1 - 0.04 14.1 7.6 0.053 13.7 7.6 1.1 1 0 0 1 1 1 0 EamA-like transporter family Cation_efflux PF01545.21 KOO24220.1 - 0.12 12.1 4.1 0.17 11.6 4.1 1.2 1 0 0 1 1 1 0 Cation efflux family PrgI PF12666.7 KOO24220.1 - 5.1 7.9 9.7 26 5.6 0.1 2.3 2 0 0 2 2 2 0 PrgI family protein Vma12 PF11712.8 KOO24220.1 - 6.8 6.8 5.2 22 5.1 3.8 2.1 1 1 1 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase CBP_BcsG PF11658.8 KOO24221.1 - 5.1 5.4 8.4 2.1 6.7 6.0 1.5 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsG HECT PF00632.25 KOO24222.1 - 6.2e-94 314.9 0.0 9.3e-94 314.4 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ABC1 PF03109.16 KOO24224.1 - 5.3e-19 68.5 0.0 2.4e-18 66.4 0.0 2.0 1 1 0 1 1 1 1 ABC1 family FAA_hydrolase PF01557.18 KOO24225.1 - 2.4e-12 47.0 0.0 3.2e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FHA PF00498.26 KOO24226.1 - 2.3e-08 34.3 0.0 3.6e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO24226.1 - 0.0077 16.5 0.0 0.02 15.2 0.0 1.6 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Kinesin PF00225.23 KOO24227.1 - 1.4e-98 329.9 1.1 2.3e-97 325.9 1.1 2.3 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO24227.1 - 3.1e-18 66.2 0.3 1.2e-17 64.2 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 KOO24227.1 - 1.9e-08 34.7 22.7 5.2e-07 30.0 0.1 5.0 5 1 0 5 5 5 2 Kinesin-associated X PF00739.19 KOO24228.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.1 1 0 0 1 1 1 0 Trans-activation protein X FG-GAP PF01839.23 KOO24229.1 - 3.2e-17 62.3 31.1 0.00021 21.3 4.5 6.2 6 1 0 6 6 6 4 FG-GAP repeat Zn_dep_PLPC PF00882.18 KOO24229.1 - 6.8e-10 39.2 0.2 1.1e-09 38.6 0.2 1.3 1 0 0 1 1 1 1 Zinc dependent phospholipase C VCBS PF13517.6 KOO24229.1 - 2e-08 34.7 18.4 0.0011 19.5 5.2 5.1 5 1 1 6 6 6 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 KOO24229.1 - 0.26 10.6 1.0 28 4.0 0.1 3.2 3 0 0 3 3 3 0 Insecticide toxin TcdB middle/N-terminal region Pkinase PF00069.25 KOO24230.1 - 3.4e-47 161.0 0.0 4.9e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24230.1 - 1.9e-42 145.3 0.0 3.2e-42 144.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO24230.1 - 4.7e-06 25.6 0.0 7.8e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO24230.1 - 0.0025 17.2 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO24230.1 - 0.13 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family PHM7_cyt PF14703.6 KOO24231.1 - 4.9e-05 23.6 0.0 9.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter zf-RING_2 PF13639.6 KOO24233.1 - 4.5e-10 39.7 13.8 9.7e-10 38.6 13.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KOO24233.1 - 4.6e-09 36.4 9.7 1e-08 35.3 9.7 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOO24233.1 - 1.1e-08 34.7 9.1 2.2e-08 33.8 9.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO24233.1 - 7.2e-08 32.1 13.8 1.4e-07 31.2 13.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO24233.1 - 4.1e-07 29.9 4.7 4.6e-07 29.8 3.5 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOO24233.1 - 5e-07 29.5 9.2 5e-07 29.5 9.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOO24233.1 - 1.6e-05 24.5 5.3 4.6e-05 23.1 5.3 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 KOO24233.1 - 1.8e-05 24.7 5.9 3.9e-05 23.6 5.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 KOO24233.1 - 0.0001 22.2 11.5 0.00022 21.1 11.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KOO24233.1 - 0.00013 21.7 7.8 0.0003 20.6 7.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 KOO24233.1 - 0.071 12.7 9.4 0.17 11.5 9.4 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Rad50_zn_hook PF04423.14 KOO24233.1 - 0.12 12.3 2.9 0.19 11.6 0.1 2.1 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_4 PF15227.6 KOO24233.1 - 0.17 12.0 9.2 0.38 11.0 9.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 KOO24233.1 - 0.45 10.4 4.9 0.77 9.6 4.9 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.7 KOO24233.1 - 0.47 10.6 8.5 1.4 9.1 8.5 1.9 1 0 0 1 1 1 0 RING-variant domain zf-P11 PF03854.14 KOO24233.1 - 8.6 6.1 11.8 1.6 8.5 4.4 2.6 1 1 1 2 2 2 0 P-11 zinc finger RAP PF08373.10 KOO24235.1 - 3.7e-14 52.6 0.0 6.5e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 RAP domain dsrm PF00035.26 KOO24235.1 - 1.3e-12 48.3 0.0 3.6e-12 46.8 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif MTES_1575 PF18741.1 KOO24235.1 - 6.5e-07 29.4 0.0 1.9e-06 28.0 0.0 1.7 2 0 0 2 2 2 1 REase_MTES_1575 DND1_DSRM PF14709.7 KOO24235.1 - 1.4e-06 28.4 0.0 2.9e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 DUF559 PF04480.12 KOO24235.1 - 0.098 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF559) Peptidase_S10 PF00450.22 KOO24236.1 - 1.2e-79 268.7 0.0 4.2e-61 207.6 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase RNB PF00773.19 KOO24237.1 - 5.8e-45 154.0 5.7 5.1e-32 111.5 0.3 2.2 1 1 1 2 2 2 2 RNB domain Pro_isomerase PF00160.21 KOO24237.1 - 1.3e-24 87.3 0.0 2.6e-24 86.3 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PIN_4 PF13638.6 KOO24237.1 - 4.7e-15 56.0 0.1 1e-14 55.0 0.1 1.6 1 0 0 1 1 1 1 PIN domain Rrp44_S1 PF17215.3 KOO24237.1 - 1.1e-14 54.1 0.0 2.6e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 KOO24237.1 - 2.7e-09 36.9 0.0 6.5e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain OB_RNB PF08206.11 KOO24237.1 - 0.00048 19.7 0.0 1.3 8.8 0.0 2.9 3 0 0 3 3 3 2 Ribonuclease B OB domain Dis3l2_C_term PF17877.1 KOO24237.1 - 0.16 12.3 0.0 0.4 11.0 0.0 1.6 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal ATPgrasp_TupA PF14305.6 KOO24238.1 - 0.067 13.0 0.0 0.083 12.7 0.0 1.1 1 0 0 1 1 1 0 TupA-like ATPgrasp PDZ_6 PF17820.1 KOO24239.1 - 7.2e-09 35.4 0.1 3.7e-08 33.1 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO24239.1 - 2.3e-07 31.0 0.0 7.1e-07 29.5 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO24239.1 - 5.1e-05 23.5 0.0 0.00011 22.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Peptidase_M10 PF00413.24 KOO24239.1 - 0.00057 19.8 0.1 0.3 10.9 0.1 2.6 3 0 0 3 3 3 2 Matrixin Peptidase_M57 PF12388.8 KOO24239.1 - 0.048 13.3 0.2 0.091 12.4 0.2 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase DUF4953 PF16313.5 KOO24239.1 - 0.16 11.2 0.3 0.32 10.1 0.3 1.5 1 0 0 1 1 1 0 Met-zincin Astacin PF01400.24 KOO24239.1 - 0.49 10.0 1.6 1.4 8.5 1.6 1.7 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Nucleotid_trans PF03407.16 KOO24240.1 - 6.4e-10 39.4 0.2 8e-10 39.0 0.2 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase UPF0370 PF13980.6 KOO24241.1 - 0.18 11.9 0.2 0.37 10.8 0.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) DUF3431 PF11913.8 KOO24242.1 - 7.9e-06 25.8 0.0 0.051 13.3 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3431) HEAT_2 PF13646.6 KOO24243.1 - 5.4e-64 212.6 84.8 4.1e-13 49.5 4.1 8.0 1 1 6 9 9 9 8 HEAT repeats HEAT PF02985.22 KOO24243.1 - 5.7e-59 191.0 34.0 0.0012 18.9 0.0 14.9 15 1 0 15 15 15 14 HEAT repeat HEAT_EZ PF13513.6 KOO24243.1 - 5.3e-42 141.8 57.5 6.1e-06 26.6 0.8 13.2 11 1 3 14 14 14 12 HEAT-like repeat Cohesin_HEAT PF12765.7 KOO24243.1 - 1.3e-21 76.5 67.0 0.0063 16.8 0.2 14.9 15 0 0 15 15 15 9 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 KOO24243.1 - 9.7e-21 74.5 12.6 0.0034 17.4 0.0 8.3 3 2 7 10 10 10 10 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KOO24243.1 - 2.5e-19 69.2 21.1 0.00091 17.9 0.3 5.1 1 1 4 5 5 5 5 Adaptin N terminal region Arm PF00514.23 KOO24243.1 - 6.8e-19 67.2 23.0 1.2 9.3 0.0 12.0 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 KOO24243.1 - 3.1e-09 37.0 0.7 0.17 12.1 0.0 6.5 2 2 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 KOO24243.1 - 1.4e-08 34.6 8.8 1.7 8.1 0.1 8.0 1 1 6 8 8 8 2 CLASP N terminal IFRD PF05004.13 KOO24243.1 - 3.3e-05 23.2 27.3 0.079 12.1 0.5 8.7 1 1 7 9 9 9 2 Interferon-related developmental regulator (IFRD) V-ATPase_H_C PF11698.8 KOO24243.1 - 0.0015 18.7 0.3 1.2e+02 2.8 0.0 6.9 5 2 3 9 9 9 0 V-ATPase subunit H DUF3263 PF11662.8 KOO24243.1 - 0.0025 17.6 21.0 29 4.6 0.0 9.7 11 0 0 11 11 11 0 Protein of unknown function (DUF3263) DUF5071 PF16804.5 KOO24243.1 - 0.014 15.6 0.0 24 5.2 0.0 4.4 1 1 3 5 5 5 0 Domain of unknown function (DUF5071) Tti2 PF10521.9 KOO24243.1 - 0.019 14.5 0.0 94 2.4 0.0 5.5 3 2 4 8 8 8 0 Tti2 family DNA_alkylation PF08713.11 KOO24243.1 - 0.069 12.9 7.0 15 5.2 0.0 4.7 1 1 1 5 5 5 0 DNA alkylation repair enzyme RasGEF_N_2 PF14663.6 KOO24243.1 - 1.2 9.5 3.1 2.5e+02 2.1 0.0 5.5 7 2 1 9 9 7 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain EF-hand_1 PF00036.32 KOO24244.1 - 3.4e-14 51.2 0.1 2.5e-06 26.6 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO24244.1 - 2.3e-13 48.9 0.1 2.4e-06 27.0 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO24244.1 - 3.1e-11 42.3 0.4 1.1e-05 24.7 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO24244.1 - 1.3e-10 41.6 0.2 3.7e-10 40.1 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO24244.1 - 7.1e-08 32.2 0.5 1.1e-05 25.2 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO24244.1 - 0.013 15.5 0.1 7.1 6.6 0.0 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand SdrD_B PF17210.3 KOO24244.1 - 0.085 13.1 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 SdrD B-like domain Caleosin PF05042.13 KOO24244.1 - 0.16 11.9 0.0 8 6.4 0.0 2.4 1 1 1 2 2 2 0 Caleosin related protein Ank PF00023.30 KOO24245.1 - 2.4e-15 56.2 0.2 1.3e-06 28.6 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 KOO24245.1 - 8.6e-15 55.1 0.0 2.9e-12 47.0 0.0 2.7 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO24245.1 - 1.5e-12 47.8 0.1 4.6e-06 27.1 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24245.1 - 1e-09 37.8 0.0 0.0013 19.1 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOO24245.1 - 2.4e-08 34.1 0.1 0.0001 22.5 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) OTU PF02338.19 KOO24245.1 - 2.3e-05 24.9 0.0 4.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease AraC_binding_2 PF14525.6 KOO24245.1 - 0.021 14.5 2.5 1.7 8.3 0.0 2.8 3 0 0 3 3 3 0 AraC-binding-like domain PDZ_6 PF17820.1 KOO24246.1 - 3.4e-12 46.0 2.7 1e-05 25.3 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 KOO24246.1 - 1.2e-08 35.1 0.1 6.8e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 KOO24246.1 - 0.014 15.4 0.2 0.46 10.5 0.0 2.5 2 0 0 2 2 2 0 Tricorn protease PDZ domain Gal-3-0_sulfotr PF06990.11 KOO24247.1 - 0.00021 20.3 0.0 0.00054 19.0 0.0 1.6 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase ShK PF01549.24 KOO24247.1 - 0.0028 18.1 4.0 0.0028 18.1 4.0 2.2 2 0 0 2 2 2 1 ShK domain-like CRAL_TRIO PF00650.20 KOO24248.1 - 7e-12 45.3 0.0 8.7e-12 45.0 0.0 1.3 1 1 0 1 1 1 1 CRAL/TRIO domain UPF0669 PF17065.5 KOO24248.1 - 0.056 13.2 0.1 0.078 12.7 0.1 1.2 1 0 0 1 1 1 0 Putative cytokine, C6ORF120 Choline_kinase PF01633.20 KOO24249.1 - 7e-12 45.4 0.0 1.5e-11 44.3 0.0 1.4 1 1 0 1 1 1 1 Choline/ethanolamine kinase CDKN3 PF05706.12 KOO24249.1 - 0.00011 21.9 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.20 KOO24249.1 - 0.0047 16.7 0.0 0.0076 16.1 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KOO24249.1 - 0.0071 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KOO24249.1 - 0.045 13.3 0.0 0.071 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF3342 PF11822.8 KOO24250.1 - 1.5e-19 69.9 0.0 2.7e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB PF00651.31 KOO24250.1 - 0.00029 21.0 0.0 0.00051 20.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain RT_RNaseH_2 PF17919.1 KOO24250.1 - 0.092 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase SET PF00856.28 KOO24251.1 - 7.7e-14 52.4 0.1 2.6e-12 47.5 0.1 2.2 1 1 0 1 1 1 1 SET domain SAF PF08666.12 KOO24251.1 - 0.043 14.5 0.0 1.4 9.6 0.0 2.4 2 0 0 2 2 2 0 SAF domain TRAM_LAG1_CLN8 PF03798.16 KOO24252.1 - 1.9e-27 96.3 8.9 3.2e-27 95.6 8.9 1.4 1 1 0 1 1 1 1 TLC domain Aldo_ket_red PF00248.21 KOO24253.1 - 1.8e-45 155.4 0.0 2.1e-45 155.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Myb_DNA-binding PF00249.31 KOO24254.1 - 9.9e-10 38.5 0.0 2.1e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO24254.1 - 1.6e-07 31.5 0.0 2.3e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain LRR_4 PF12799.7 KOO24255.1 - 6.7e-13 48.6 9.4 1.1e-06 28.9 3.0 3.8 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO24255.1 - 1.9e-11 43.6 8.3 6.5e-06 25.8 0.8 3.8 3 1 0 3 3 3 3 Leucine rich repeat RhoGAP PF00620.27 KOO24255.1 - 2.1e-11 43.8 0.0 4e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain LRR_9 PF14580.6 KOO24255.1 - 2.3e-08 33.7 0.1 0.0013 18.3 0.3 2.2 2 0 0 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 KOO24255.1 - 0.0011 18.9 7.8 1.1 9.5 0.1 5.1 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 KOO24255.1 - 0.019 15.5 4.5 12 6.9 0.0 5.0 4 1 0 4 4 4 0 Leucine Rich Repeat SelK_SelG PF10961.8 KOO24255.1 - 0.12 13.0 0.1 0.33 11.6 0.1 1.7 1 0 0 1 1 1 0 Selenoprotein SelK_SelG APH PF01636.23 KOO24256.1 - 5.8e-10 39.5 0.4 3.6e-09 36.9 0.4 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 KOO24256.1 - 8.4e-07 28.6 0.0 4.5e-06 26.2 0.0 2.1 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 KOO24256.1 - 0.044 13.4 0.0 0.071 12.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase IFRD PF05004.13 KOO24257.1 - 0.0086 15.2 0.6 0.016 14.3 0.6 1.4 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) F_actin_bind PF08919.10 KOO24257.1 - 0.17 12.0 0.8 9.3 6.4 0.0 3.3 2 1 0 3 3 3 0 F-actin binding Pox_A_type_inc PF04508.12 KOO24257.1 - 0.38 10.7 0.0 0.38 10.7 0.0 3.0 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat HIP1_clath_bdg PF16515.5 KOO24257.1 - 0.98 10.1 7.5 1 10.0 5.2 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Thioredoxin PF00085.20 KOO24258.1 - 3.4e-22 78.4 0.0 4.4e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KOO24258.1 - 3.3e-05 24.1 0.0 0.0022 18.3 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 KOO24258.1 - 9.3e-05 22.8 0.0 0.00086 19.7 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain HyaE PF07449.11 KOO24258.1 - 0.00053 19.9 0.0 0.00092 19.2 0.0 1.4 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 KOO24258.1 - 0.0011 18.8 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 KOO24258.1 - 0.0038 17.4 0.0 0.0072 16.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 KOO24258.1 - 0.0058 16.5 0.0 0.0074 16.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family TraF PF13728.6 KOO24258.1 - 0.058 13.2 0.0 0.077 12.8 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 KOO24258.1 - 0.087 12.9 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Redoxin PF08534.10 KOO24258.1 - 0.12 12.1 0.0 0.29 10.9 0.0 1.4 1 1 0 1 1 1 0 Redoxin HAUS-augmin3 PF14932.6 KOO24260.1 - 0.37 10.3 17.5 0.51 9.9 17.5 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 V_ATPase_I PF01496.19 KOO24260.1 - 4.7 5.0 7.2 6.6 4.5 7.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFIIA PF03153.13 KOO24260.1 - 9.5 6.1 12.5 11 5.9 12.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CC2D2AN-C2 PF15625.6 KOO24261.1 - 9e-22 77.6 0.0 1.9e-21 76.6 0.0 1.6 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain C2 PF00168.30 KOO24261.1 - 7.4e-05 23.0 0.0 0.00085 19.6 0.0 2.4 2 0 0 2 2 2 1 C2 domain Octopine_DH PF02317.17 KOO24262.1 - 1.4e-22 80.4 0.0 1.9e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain NAD_Gly3P_dh_N PF01210.23 KOO24262.1 - 0.00029 20.9 0.0 0.00067 19.7 0.0 1.6 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 KOO24262.1 - 0.034 13.8 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sld3_N PF18523.1 KOO24262.1 - 0.084 13.0 0.1 0.17 12.0 0.1 1.4 1 0 0 1 1 1 0 Sld3 N-terminal domain F420_oxidored PF03807.17 KOO24262.1 - 0.097 13.3 0.0 0.29 11.7 0.0 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent EF-hand_1 PF00036.32 KOO24264.1 - 2e-25 86.4 1.3 1.3e-05 24.4 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO24264.1 - 3e-24 82.8 1.1 3e-05 23.6 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO24264.1 - 1.9e-22 77.7 1.4 1.2e-05 24.6 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO24264.1 - 8.6e-22 77.4 0.3 1.6e-10 41.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO24264.1 - 4.4e-16 58.5 5.0 6.3e-05 22.7 0.1 4.1 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO24264.1 - 4.2e-06 27.1 0.1 0.14 12.5 0.0 2.5 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO24264.1 - 0.00017 21.5 0.9 0.012 15.6 0.2 2.8 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Sigma70_r1_1 PF03979.14 KOO24264.1 - 0.0035 17.4 0.1 0.34 11.0 0.0 2.4 2 0 0 2 2 2 1 Sigma-70 factor, region 1.1 EF-hand_9 PF14658.6 KOO24264.1 - 0.0051 17.1 0.1 4.2 7.8 0.0 3.4 2 2 2 4 4 4 1 EF-hand domain Dockerin_1 PF00404.18 KOO24264.1 - 0.74 10.1 6.0 4.7 7.5 0.1 2.9 2 1 1 3 3 3 0 Dockerin type I domain GCN5L1 PF06320.13 KOO24265.1 - 0.56 10.4 6.0 0.81 9.9 0.3 2.3 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Acetyltransf_1 PF00583.25 KOO24266.1 - 1.1e-05 25.7 0.0 3.3e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Macro PF01661.21 KOO24267.1 - 1.8e-12 47.3 0.0 2.4e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Macro domain Ammonium_transp PF00909.21 KOO24269.1 - 6.4e-105 351.1 30.9 7.5e-105 350.9 30.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family PARP PF00644.20 KOO24270.1 - 1.4e-13 50.8 0.5 3.1e-09 36.7 0.0 2.4 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Ank_4 PF13637.6 KOO24271.1 - 1.1e-21 76.9 5.5 3e-08 34.1 0.1 3.4 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO24271.1 - 4.4e-21 75.3 0.0 2e-10 41.1 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO24271.1 - 7.6e-17 61.2 3.2 3.6e-09 36.7 0.3 2.7 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24271.1 - 3.2e-14 51.6 0.0 0.00042 20.6 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO24271.1 - 4.8e-13 48.9 0.8 1.1e-05 25.6 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Acetyltransf_6 PF13480.7 KOO24271.1 - 0.041 14.0 0.5 0.081 13.1 0.2 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain WD40 PF00400.32 KOO24272.1 - 2e-19 69.6 9.8 0.089 13.7 0.1 9.8 10 0 0 10 10 10 6 WD domain, G-beta repeat HELP PF03451.14 KOO24272.1 - 2e-10 40.4 0.3 1.1e-09 38.0 0.3 2.1 1 1 0 1 1 1 1 HELP motif ANAPC4_WD40 PF12894.7 KOO24272.1 - 2.8e-09 37.2 0.0 0.0018 18.5 0.0 4.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_7 PF13499.6 KOO24272.1 - 1.4e-07 31.8 0.0 0.014 15.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO24272.1 - 0.08 12.5 0.0 13 5.6 0.0 2.6 2 0 0 2 2 2 0 EF hand IATP PF04568.12 KOO24272.1 - 1.8 9.1 4.9 5.3 7.5 4.9 1.8 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP SlyX PF04102.12 KOO24272.1 - 2.6 8.7 7.3 0.3 11.7 2.2 2.1 2 0 0 2 2 2 0 SlyX TBCC_N PF16752.5 KOO24273.1 - 0.13 12.7 3.0 26 5.3 0.1 3.1 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain DUF563 PF04577.14 KOO24274.1 - 2.6e-05 24.5 0.1 3.6e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Acyl-CoA_dh_N PF02771.16 KOO24275.1 - 0.28 11.9 2.4 1.6 9.4 0.1 2.5 1 1 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain DUF2388 PF09498.10 KOO24275.1 - 5.4 7.1 13.8 4 7.5 2.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2388) Chloroa_b-bind PF00504.21 KOO24276.1 - 2.2e-31 109.6 0.0 2.9e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein GST_C_3 PF14497.6 KOO24277.1 - 3.9e-13 49.4 0.0 5.8e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOO24277.1 - 3.7e-11 42.9 0.0 7e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOO24277.1 - 3.6e-09 36.9 0.0 9.3e-09 35.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOO24277.1 - 4.1e-09 36.5 0.0 6.2e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOO24277.1 - 3.6e-05 24.1 0.0 6.8e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO24277.1 - 0.00011 22.4 0.0 0.00041 20.6 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 KOO24277.1 - 0.0074 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KOO24277.1 - 0.056 14.2 0.0 0.1 13.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Cyclase PF04199.13 KOO24279.1 - 1.3e-20 74.0 0.0 1.8e-20 73.6 0.0 1.4 1 1 0 1 1 1 1 Putative cyclase HAD_2 PF13419.6 KOO24279.1 - 1.4e-08 35.0 0.0 4e-08 33.5 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO24279.1 - 1.5e-08 35.2 0.3 3.7e-07 30.6 0.3 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOO24279.1 - 7.7e-05 23.2 0.1 0.00026 21.4 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_hydro_63 PF03200.16 KOO24280.1 - 2.7e-94 316.7 0.0 1.6e-61 208.6 0.0 2.0 2 0 0 2 2 2 2 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 KOO24280.1 - 1.5e-31 110.2 0.0 2.3e-30 106.4 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain GDE_C PF06202.14 KOO24280.1 - 0.0047 15.9 0.1 0.0078 15.2 0.1 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Trehalase PF01204.18 KOO24280.1 - 0.0058 15.5 0.4 0.34 9.7 0.0 2.1 2 0 0 2 2 2 2 Trehalase Ank_2 PF12796.7 KOO24281.1 - 6.2e-13 49.1 0.4 3.6e-07 30.7 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO24281.1 - 3.9e-10 39.8 0.2 0.00079 19.7 0.0 4.0 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO24281.1 - 8e-09 35.9 0.2 8.4e-06 26.2 0.0 3.4 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24281.1 - 2e-08 33.8 0.7 0.0052 17.2 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOO24281.1 - 6.8e-06 26.3 7.0 0.0025 18.2 0.0 4.4 5 0 0 5 5 5 1 Ankyrin repeat DUF1793 PF08760.11 KOO24284.1 - 6.4e-40 137.3 0.4 4.3e-39 134.6 0.4 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 KOO24284.1 - 1.1e-08 34.9 0.0 2.4e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) SPDY PF03771.16 KOO24284.1 - 0.12 12.3 3.1 1.7 8.6 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF317) DUF1953 PF09196.10 KOO24285.1 - 0.016 15.0 1.5 0.022 14.6 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1953) COPIIcoated_ERV PF07970.12 KOO24286.1 - 2e-34 119.4 0.3 2e-34 119.4 0.3 1.5 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOO24286.1 - 4.2e-25 87.9 0.3 4.2e-25 87.9 0.3 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.20 KOO24286.1 - 3e-16 59.3 0.0 6.5e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 KOO24286.1 - 0.011 15.8 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like Helicase_C PF00271.31 KOO24287.1 - 1.3e-20 73.8 0.0 2e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 KOO24287.1 - 3e-06 27.1 0.5 8.4e-06 25.6 0.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SNF2_N PF00176.23 KOO24287.1 - 5.9e-06 25.2 0.0 9.7e-06 24.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HDA2-3 PF11496.8 KOO24287.1 - 3.2e-05 23.2 0.0 9.8e-05 21.7 0.0 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 HATPase_c_3 PF13589.6 KOO24291.1 - 2.3e-10 40.4 0.0 5.9e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cupin_8 PF13621.6 KOO24292.1 - 1.1e-37 130.1 0.0 1.9e-37 129.3 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO24292.1 - 7.1e-07 29.0 0.0 1.4e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Cupin superfamily protein ATP_bind_3 PF01171.20 KOO24294.1 - 4.7e-40 137.3 0.1 3.8e-39 134.3 0.1 2.0 1 1 0 1 1 1 1 PP-loop family TilS_C PF11734.8 KOO24294.1 - 0.0027 17.1 0.8 0.0066 15.8 0.2 2.0 2 0 0 2 2 2 1 TilS substrate C-terminal domain Ion_trans PF00520.31 KOO24295.1 - 1.4e-06 27.7 1.7 1.4e-06 27.7 1.7 2.0 2 0 0 2 2 2 1 Ion transport protein ERF PF04404.12 KOO24295.1 - 0.089 12.7 0.0 0.29 11.0 0.0 1.8 2 0 0 2 2 2 0 ERF superfamily UQ_con PF00179.26 KOO24297.1 - 2.7e-41 140.5 0.0 3.8e-41 140.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO24297.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 KOO24297.1 - 0.088 13.1 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain Acid_PPase PF12689.7 KOO24298.1 - 1.2e-31 109.8 0.0 1.3e-31 109.7 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase DUF2608 PF11019.8 KOO24298.1 - 0.2 11.1 0.0 0.26 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) MMR_HSR1 PF01926.23 KOO24299.1 - 3.1e-13 49.8 0.0 8.4e-13 48.4 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO24299.1 - 1.5e-06 28.3 0.0 0.079 12.9 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 KOO24299.1 - 0.00017 21.2 0.0 0.00047 19.7 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B Kinesin PF00225.23 KOO24301.1 - 2.3e-79 266.7 0.0 4.1e-68 229.7 0.0 2.4 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KOO24301.1 - 2e-18 66.8 0.0 5e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding DEAD PF00270.29 KOO24301.1 - 0.072 12.9 1.3 7.8 6.2 0.1 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase Pepsin-I3 PF06394.13 KOO24301.1 - 1 9.6 3.9 1.8 8.8 2.6 2.1 1 1 1 2 2 2 0 Pepsin inhibitor-3-like repeated domain AAA_lid_9 PF17871.1 KOO24302.1 - 0.006 16.5 0.0 0.006 16.5 0.0 2.3 1 1 1 2 2 2 1 AAA lid domain BAF1_ABF1 PF04684.13 KOO24302.1 - 0.05 12.7 3.8 0.046 12.8 3.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DREPP PF05558.12 KOO24304.1 - 0.019 14.9 4.6 0.034 14.0 4.6 1.4 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Amino_oxidase PF01593.24 KOO24306.1 - 2e-73 248.2 0.0 2.3e-73 248.0 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO24306.1 - 2.3e-16 59.8 0.1 5.6e-16 58.5 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO24306.1 - 3.6e-09 36.7 0.0 0.00045 19.9 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOO24306.1 - 5.7e-07 29.0 0.0 8.5e-06 25.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO24306.1 - 2.4e-06 28.0 0.0 0.0025 18.4 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 KOO24306.1 - 8.7e-06 24.8 0.0 0.1 11.4 0.0 2.1 2 0 0 2 2 2 2 MCRA family FAD_binding_2 PF00890.24 KOO24306.1 - 0.00059 19.0 0.3 0.011 14.9 0.2 2.2 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 KOO24306.1 - 0.0017 17.1 0.2 0.005 15.6 0.2 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 KOO24306.1 - 0.0029 16.9 0.1 0.0054 16.0 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 KOO24306.1 - 0.0061 15.5 0.0 0.79 8.5 0.0 2.4 2 0 0 2 2 2 1 Tryptophan halogenase Thi4 PF01946.17 KOO24306.1 - 0.0077 15.5 0.2 0.015 14.5 0.2 1.5 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 KOO24306.1 - 0.0091 15.4 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FMO-like PF00743.19 KOO24306.1 - 0.012 14.0 0.1 0.022 13.2 0.1 1.3 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KOO24306.1 - 0.16 11.2 0.9 0.26 10.5 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Galactosyl_T PF01762.21 KOO24308.1 - 0.00085 19.2 0.0 0.0041 17.0 0.0 2.1 1 1 0 1 1 1 1 Galactosyltransferase WW PF00397.26 KOO24310.1 - 1.4e-09 37.9 8.1 2.7e-09 37.0 8.1 1.5 1 0 0 1 1 1 1 WW domain PDZ PF00595.24 KOO24310.1 - 6.8e-07 29.6 0.3 1.3e-06 28.6 0.3 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO24310.1 - 0.0084 15.9 0.2 0.021 14.7 0.2 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO24310.1 - 0.013 15.8 0.3 0.03 14.6 0.3 1.6 1 0 0 1 1 1 0 PDZ domain Glyco_hyd_101C PF17451.2 KOO24310.1 - 0.018 15.3 0.1 0.036 14.3 0.1 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase 101 beta sandwich domain DUF2390 PF09523.10 KOO24311.1 - 5 7.5 7.6 2.5 8.5 3.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2390) Pex19 PF04614.12 KOO24312.1 - 0.19 11.5 3.4 0.22 11.3 3.4 1.1 1 0 0 1 1 1 0 Pex19 protein family Topo-VIb_trans PF09239.11 KOO24313.1 - 6.5e-50 169.1 0.0 1.2e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 Topoisomerase VI B subunit, transducer HATPase_c_3 PF13589.6 KOO24313.1 - 1.5e-07 31.4 0.5 5.7e-06 26.2 0.0 2.6 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOO24313.1 - 3.4e-07 30.8 0.0 2e-06 28.3 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FbpA PF05833.11 KOO24313.1 - 0.00065 18.6 0.0 0.0013 17.6 0.0 1.4 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Rieske PF00355.26 KOO24315.1 - 1.7e-11 43.9 0.3 2.8e-11 43.2 0.3 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 KOO24315.1 - 6.2e-09 36.2 0.3 1.1e-08 35.4 0.3 1.4 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region CHS5_N PF16892.5 KOO24316.1 - 0.005 16.8 0.1 0.0068 16.3 0.1 1.2 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus DUF3006 PF11213.8 KOO24316.1 - 0.0072 16.5 0.0 0.0088 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) P66_CC PF16563.5 KOO24316.1 - 0.035 13.7 0.9 0.066 12.8 0.2 1.8 2 0 0 2 2 2 0 Coiled-coil and interaction region of P66A and P66B with MBD2 ILVD_EDD PF00920.21 KOO24317.1 - 2.4e-180 600.6 2.5 2.7e-180 600.4 2.5 1.0 1 0 0 1 1 1 1 Dehydratase family Patched PF02460.18 KOO24318.1 - 7.8e-06 24.3 24.1 0.00078 17.7 19.1 2.4 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 KOO24318.1 - 8.6e-06 25.7 3.1 8.6e-06 25.7 3.1 3.2 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Holin_SPP1 PF04688.13 KOO24318.1 - 1.6 9.0 3.3 6.1 7.1 0.0 3.4 3 0 0 3 3 3 0 SPP1 phage holin DAO PF01266.24 KOO24319.1 - 2.3e-09 37.3 1.0 6.7e-09 35.8 1.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase EF-hand_1 PF00036.32 KOO24320.1 - 2.7e-12 45.3 0.6 2.3e-07 29.9 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO24320.1 - 9.3e-10 38.8 0.4 1.4e-09 38.3 0.4 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO24320.1 - 7.8e-09 34.8 0.1 6.9e-06 25.6 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO24320.1 - 6.8e-08 31.7 0.8 5.2e-06 25.7 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO24320.1 - 1.2e-07 31.4 1.4 1.4e-05 24.9 0.4 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO24320.1 - 0.0072 16.3 0.1 0.63 10.0 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO24320.1 - 0.014 15.7 0.0 0.055 13.8 0.0 1.7 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2226 PF09987.9 KOO24320.1 - 0.019 14.3 0.1 0.025 13.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2226) CAP_N PF01213.19 KOO24320.1 - 3.1 7.2 8.5 5.7 6.3 6.6 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal DAO PF01266.24 KOO24321.1 - 1.7e-24 87.1 2.6 2.1e-24 86.8 2.6 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAE1_CUT1_RppA PF08392.12 KOO24322.1 - 8.4e-107 356.8 0.3 2.1e-106 355.4 0.3 1.6 1 1 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Chal_sti_synt_C PF02797.15 KOO24322.1 - 3.6e-11 43.3 0.0 6.5e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain ACP_syn_III_C PF08541.10 KOO24322.1 - 1.5e-08 34.7 0.0 0.0003 20.9 0.0 2.5 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 KOO24322.1 - 0.00017 21.4 0.1 0.00045 20.0 0.1 1.6 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Histone_H2A_C PF16211.5 KOO24324.1 - 3.3e-19 68.3 0.3 6.8e-19 67.3 0.3 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KOO24324.1 - 9.5e-16 58.4 0.0 1.2e-15 58.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOO24324.1 - 5.1e-06 26.7 0.0 7.1e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CAP_GLY PF01302.25 KOO24325.1 - 7.7e-24 83.5 0.1 1.3e-23 82.8 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain EF-hand_1 PF00036.32 KOO24325.1 - 8.5e-12 43.7 2.8 2.4e-05 23.5 1.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO24325.1 - 1.1e-08 35.3 0.3 2.4e-08 34.3 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO24325.1 - 2.2e-06 26.9 1.1 0.0074 15.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO24325.1 - 6.7e-06 25.6 0.3 0.0064 16.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO24325.1 - 1.6e-05 24.6 1.9 1.6e-05 24.6 1.9 2.4 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_4 PF12763.7 KOO24325.1 - 0.00075 19.4 0.1 0.0021 18.0 0.1 1.8 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO24325.1 - 0.0015 18.8 0.0 0.0045 17.3 0.0 1.8 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO24325.1 - 0.022 15.1 0.1 0.052 13.9 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain Dockerin_1 PF00404.18 KOO24325.1 - 0.19 12.0 1.4 0.42 10.8 1.4 1.6 1 0 0 1 1 1 0 Dockerin type I domain DAGAT PF03982.13 KOO24326.1 - 1.3e-40 139.1 0.0 1.6e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.21 KOO24326.1 - 0.0078 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase DUF2475 PF10629.9 KOO24327.1 - 0.11 12.7 11.6 0.62 10.3 0.1 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2475) Histone PF00125.24 KOO24329.1 - 3.4e-20 72.7 0.3 4.8e-20 72.3 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOO24329.1 - 0.00061 20.0 0.0 0.0014 18.9 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KOO24329.1 - 0.0083 16.6 0.0 0.014 15.9 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KOO24329.1 - 0.0089 16.1 0.9 0.011 15.8 0.9 1.2 1 0 0 1 1 1 1 YscO-like protein zf-RING_2 PF13639.6 KOO24330.1 - 8.9e-09 35.6 10.0 1.4e-08 35.0 10.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOO24330.1 - 4.1e-06 26.4 2.9 4.1e-06 26.4 2.9 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 KOO24330.1 - 1.1e-05 25.6 11.1 4.3e-05 23.7 11.1 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KOO24330.1 - 2e-05 24.3 9.9 4e-05 23.4 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KOO24330.1 - 7.7e-05 22.7 0.9 0.00015 21.7 0.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 KOO24330.1 - 0.00026 20.9 3.4 0.00026 20.9 3.4 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOO24330.1 - 0.00036 20.3 8.2 0.00066 19.5 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO24330.1 - 0.0037 17.2 6.9 0.006 16.5 6.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain FANCL_C PF11793.8 KOO24330.1 - 0.008 16.3 7.8 0.084 13.1 7.8 2.2 1 1 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 KOO24330.1 - 0.076 12.9 8.8 0.15 11.9 8.8 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO24330.1 - 0.22 11.4 7.1 0.59 10.0 7.2 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 KOO24330.1 - 0.58 9.8 5.2 1 9.0 5.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 KOO24330.1 - 2.2 8.5 6.6 4.4 7.5 6.6 1.5 1 1 0 1 1 1 0 RING-variant domain ASH PF15780.5 KOO24331.1 - 1.6e-18 66.7 0.5 0.003 17.7 0.0 8.2 9 0 0 9 9 9 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 KOO24331.1 - 0.0029 17.7 0.2 0.73 10.0 0.0 4.2 4 1 0 4 4 4 1 Flagellar-associated PapD-like DUF1573 PF07610.11 KOO24331.1 - 0.02 14.9 0.0 13 5.9 0.0 4.9 7 0 0 7 7 7 0 Protein of unknown function (DUF1573) WD40 PF00400.32 KOO24332.1 - 2.8e-16 59.6 18.3 0.00049 20.8 0.1 6.6 6 1 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 KOO24332.1 - 0.066 11.9 0.1 3 6.4 0.0 2.3 2 0 0 2 2 2 0 Nucleoporin Nup120/160 SSB PF00436.25 KOO24332.1 - 0.073 13.1 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Single-strand binding protein family PALP PF00291.25 KOO24333.1 - 8.8e-55 186.2 4.0 9.8e-55 186.0 4.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SCO1-SenC PF02630.14 KOO24334.1 - 1.5e-45 154.4 0.0 2.3e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 KOO24334.1 - 1.3e-08 34.7 0.0 6.2e-08 32.6 0.0 1.9 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 KOO24334.1 - 0.00012 22.3 0.0 0.00019 21.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 KOO24334.1 - 0.017 14.9 0.0 0.14 11.8 0.0 2.1 1 1 0 1 1 1 0 Redoxin IMPDH PF00478.25 KOO24335.1 - 2.7e-83 279.8 0.9 3.9e-83 279.3 0.9 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KOO24335.1 - 0.00077 18.6 5.7 0.00096 18.3 4.7 1.4 1 1 0 1 1 1 1 FMN-dependent dehydrogenase PAP2_C PF14360.6 KOO24335.1 - 0.016 15.8 0.3 0.034 14.7 0.3 1.5 1 0 0 1 1 1 0 PAP2 superfamily C-terminal PGM_PMM_III PF02880.16 KOO24335.1 - 0.033 14.4 0.3 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III NHL PF01436.21 KOO24336.1 - 5.9e-21 73.4 7.3 4.3e-05 23.3 0.5 5.3 5 0 0 5 5 5 4 NHL repeat DUF5128 PF17170.4 KOO24336.1 - 5e-08 32.5 0.0 0.0025 17.0 0.0 2.6 2 1 0 2 2 2 2 6-bladed beta-propeller SGL PF08450.12 KOO24336.1 - 0.012 15.3 0.0 0.12 11.9 0.0 2.3 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region TolB_like PF15869.5 KOO24336.1 - 0.055 12.7 0.0 3 7.0 0.0 2.4 2 0 0 2 2 2 0 TolB-like 6-blade propeller-like AAA_12 PF13087.6 KOO24337.1 - 1.9e-10 40.7 0.0 2.3e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 AAA domain RVT_2 PF07727.14 KOO24338.1 - 1.2e-25 90.6 0.0 1.8e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Neocarzinostat PF00960.18 KOO24338.1 - 0.12 12.4 1.9 1.3 9.0 1.7 2.5 2 0 0 2 2 2 0 Neocarzinostatin family PARP PF00644.20 KOO24339.1 - 0.00046 19.8 0.1 0.0011 18.6 0.0 1.7 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain AAA_22 PF13401.6 KOO24340.1 - 0.011 16.1 1.4 0.027 14.7 1.4 1.6 1 1 0 1 1 1 0 AAA domain zf-MYND PF01753.18 KOO24343.1 - 4.9e-09 36.1 12.3 2e-08 34.2 12.3 2.1 1 1 0 1 1 1 1 MYND finger DUF4191 PF13829.6 KOO24343.1 - 0.027 13.8 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Peptidase_C97 PF05903.14 KOO24344.1 - 3.9e-33 114.4 0.0 5.5e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUL PF08324.11 KOO24344.1 - 4.5e-13 49.1 3.6 6.5e-13 48.5 3.6 1.2 1 0 0 1 1 1 1 PUL domain LigA PF07746.11 KOO24344.1 - 0.2 11.8 0.0 0.39 10.9 0.0 1.4 1 0 0 1 1 1 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit CPBP PF02517.16 KOO24345.1 - 2.5e-15 56.6 7.5 2.5e-15 56.6 7.5 2.0 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease p450 PF00067.22 KOO24347.1 - 1.5e-12 47.0 0.0 2e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 LRR_6 PF13516.6 KOO24348.1 - 5.6e-07 29.1 0.1 0.0045 16.9 0.0 3.1 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.7 KOO24348.1 - 0.0022 18.3 0.0 1.3 9.6 0.0 2.3 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Ank_2 PF12796.7 KOO24348.1 - 0.012 16.2 0.0 0.015 15.8 0.0 1.2 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) LRR_8 PF13855.6 KOO24348.1 - 0.013 15.3 0.2 4.2 7.2 0.1 2.5 2 1 0 2 2 2 0 Leucine rich repeat RRM_1 PF00076.22 KOO24349.1 - 2.1e-05 24.3 0.0 3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Abhydrolase_2 PF02230.16 KOO24351.1 - 9.1e-13 48.5 0.1 2.2e-12 47.2 0.1 1.6 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 KOO24351.1 - 0.0037 17.9 0.0 0.0088 16.7 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF5302 PF17227.2 KOO24351.1 - 0.038 15.0 0.9 0.083 13.9 0.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5302) Abhydrolase_3 PF07859.13 KOO24351.1 - 0.041 13.7 0.0 0.067 13.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DLH PF01738.18 KOO24351.1 - 0.092 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family DHHC PF01529.20 KOO24353.1 - 4.4e-19 68.9 4.0 4.4e-19 68.9 4.0 3.3 2 2 1 3 3 3 1 DHHC palmitoyltransferase Helitron_like_N PF14214.6 KOO24354.1 - 1.6e-08 35.0 0.0 3.6e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus STI1 PF17830.1 KOO24354.1 - 0.028 14.4 0.0 0.087 12.8 0.0 1.8 1 0 0 1 1 1 0 STI1 domain CLP_protease PF00574.23 KOO24355.1 - 1.4e-53 181.5 0.0 1.8e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 Clp protease Tom7 PF08038.12 KOO24356.1 - 8.9e-06 25.3 0.5 1.7e-05 24.3 0.5 1.6 1 1 1 2 2 2 1 TOM7 family Bax1-I PF01027.20 KOO24357.1 - 6.3e-33 114.4 38.8 6.3e-33 114.4 38.8 1.7 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 Metallophos PF00149.28 KOO24358.1 - 9.1e-38 130.8 0.1 1.2e-37 130.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOO24358.1 - 0.001 19.4 0.0 0.0018 18.7 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain FA_desaturase PF00487.24 KOO24360.1 - 1.4e-23 84.0 12.2 1.4e-23 84.0 12.2 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Nucleotid_trans PF03407.16 KOO24361.1 - 4.3e-35 121.6 0.0 8.1e-35 120.7 0.0 1.4 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_hydro_47 PF01532.20 KOO24362.1 - 1.1e-26 93.8 0.0 1.8e-24 86.5 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Beta-Casp PF10996.8 KOO24364.1 - 4.4e-24 84.9 0.0 9.2e-24 83.9 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 KOO24364.1 - 4.1e-14 52.4 0.0 8.3e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 KOO24364.1 - 9.8e-14 51.0 0.0 3.5e-13 49.3 0.0 2.0 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain EF-hand_7 PF13499.6 KOO24364.1 - 3.4e-12 46.6 1.4 7.5e-12 45.5 1.4 1.6 1 0 0 1 1 1 1 EF-hand domain pair Lactamase_B PF00753.27 KOO24364.1 - 5.8e-11 42.8 2.6 5.8e-10 39.5 2.6 2.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily EF-hand_1 PF00036.32 KOO24364.1 - 2e-10 39.4 6.3 0.00011 21.4 0.9 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO24364.1 - 2.1e-09 37.1 4.5 1.4e-07 31.3 0.6 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO24364.1 - 7.8e-09 34.8 4.6 7.5e-05 22.4 0.3 3.2 2 1 1 3 3 3 2 EF-hand domain Lactamase_B_2 PF12706.7 KOO24364.1 - 4.2e-08 33.0 2.1 7.1e-08 32.2 0.4 2.1 2 0 0 2 2 2 1 Beta-lactamase superfamily domain EF-hand_5 PF13202.6 KOO24364.1 - 5.8e-06 25.6 8.5 0.0032 16.9 0.4 3.3 3 0 0 3 3 3 2 EF hand Lactamase_B_3 PF13483.6 KOO24364.1 - 0.007 16.3 0.0 0.027 14.4 0.0 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain EF-hand_4 PF12763.7 KOO24364.1 - 0.023 14.6 1.6 4.7 7.2 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand GPCR_chapero_1 PF11904.8 KOO24364.1 - 0.084 12.3 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 GPCR-chaperone Pkinase PF00069.25 KOO24366.1 - 8.7e-30 104.0 0.0 1.4e-29 103.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24366.1 - 1.7e-28 99.6 0.0 4.4e-17 62.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOO24366.1 - 2.6e-05 23.7 0.1 3.4e-05 23.3 0.1 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO24366.1 - 0.0072 16.3 0.1 0.037 13.9 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KOO24366.1 - 0.024 14.0 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO24366.1 - 0.14 10.9 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase DnaJ PF00226.31 KOO24367.1 - 2.4e-16 59.6 0.4 4.1e-16 58.9 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain FHA PF00498.26 KOO24367.1 - 4.8e-08 33.2 0.0 8.5e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 FHA domain ShK PF01549.24 KOO24367.1 - 6.8e-08 32.9 6.9 1.3e-07 32.0 6.9 1.4 1 0 0 1 1 1 1 ShK domain-like PCNP PF15473.6 KOO24367.1 - 0.69 10.6 4.1 1.4 9.6 4.1 1.4 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family TFIID_20kDa PF03847.13 KOO24368.1 - 1.5e-19 70.2 2.2 2.1e-19 69.8 0.3 2.3 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 KOO24368.1 - 3.3e-05 24.1 0.2 8.5e-05 22.8 0.2 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOO24368.1 - 0.0022 18.4 0.2 0.0022 18.4 0.2 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 SQHop_cyclase_N PF13249.6 KOO24370.1 - 2.7e-46 158.0 0.1 4.4e-46 157.3 0.1 1.3 1 0 0 1 1 1 1 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 KOO24370.1 - 5.6e-11 42.0 9.4 8.5e-10 38.2 0.1 3.5 4 0 0 4 4 4 2 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 KOO24370.1 - 0.00039 19.6 1.4 0.0025 17.0 0.4 2.5 2 1 1 3 3 3 2 Squalene-hopene cyclase C-terminal domain EF-hand_1 PF00036.32 KOO24371.1 - 8.8e-22 75.0 7.2 4.8e-05 22.6 0.1 5.1 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO24371.1 - 2e-20 73.0 2.8 3.3e-10 40.3 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO24371.1 - 4.2e-18 63.9 6.2 0.00021 20.6 0.1 5.0 4 1 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO24371.1 - 4.6e-18 63.5 4.2 0.0032 17.3 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 KOO24371.1 - 3.9e-17 61.8 5.6 0.0017 18.1 0.1 4.7 5 0 0 5 5 5 4 EF-hand domain pair SHOCT PF09851.9 KOO24371.1 - 9.3e-05 22.0 4.7 0.00017 21.2 0.3 3.3 3 0 0 3 3 3 1 Short C-terminal domain SPARC_Ca_bdg PF10591.9 KOO24371.1 - 0.0031 17.8 0.3 0.6 10.4 0.1 2.6 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO24371.1 - 0.085 13.2 0.2 0.44 10.9 0.0 2.2 3 0 0 3 3 3 0 EF-hand domain Cdc6_C PF09079.11 KOO24371.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain EF-hand_4 PF12763.7 KOO24371.1 - 0.53 10.3 1.4 18 5.4 0.0 3.2 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand Helicase_C PF00271.31 KOO24372.1 - 2e-19 70.0 0.0 5.2e-19 68.6 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KOO24372.1 - 9e-06 24.6 0.1 1.7e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HDA2-3 PF11496.8 KOO24372.1 - 0.0013 18.0 0.0 1.4 8.0 0.0 2.3 2 1 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 CRAL_TRIO PF00650.20 KOO24373.1 - 4e-12 46.1 0.0 5.9e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain COesterase PF00135.28 KOO24374.1 - 2.5e-78 264.2 0.0 3.4e-78 263.8 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KOO24374.1 - 6.5e-06 26.1 0.0 5.6e-05 23.1 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOO24374.1 - 4.2 7.9 8.4 5.2 7.6 6.8 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family MCD PF05292.11 KOO24375.1 - 1.9e-72 243.9 0.0 3.8e-72 243.0 0.0 1.5 1 1 0 1 1 1 1 Malonyl-CoA decarboxylase C-terminal domain MCD_N PF17408.2 KOO24375.1 - 5.5e-11 42.4 1.2 3.9e-10 39.7 1.2 2.5 1 1 0 1 1 1 1 Malonyl-CoA decarboxylase N-terminal domain DXP_synthase_N PF13292.6 KOO24376.1 - 0.024 13.9 0.0 0.05 12.8 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase XPC-binding PF09280.11 KOO24376.1 - 0.043 13.6 0.1 0.12 12.2 0.1 1.7 1 0 0 1 1 1 0 XPC-binding domain P_gingi_FimA PF06321.11 KOO24376.1 - 5.5 7.1 7.1 9.7 6.3 3.9 2.3 2 0 0 2 2 2 0 Major fimbrial subunit protein (FimA) Melibiase_2 PF16499.5 KOO24377.1 - 2.6e-50 171.2 4.7 7.1e-50 169.8 4.7 1.6 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 KOO24377.1 - 7.1e-12 45.2 0.0 1.4e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 KOO24377.1 - 1.7e-06 27.3 0.2 3.7e-06 26.1 0.0 1.5 2 0 0 2 2 2 1 Melibiase Glyco_hydro_97 PF10566.9 KOO24377.1 - 0.007 15.7 0.0 0.0098 15.2 0.0 1.1 1 0 0 1 1 1 1 Glycoside hydrolase 97 Maf PF02545.14 KOO24378.1 - 4.3e-32 111.3 0.0 6.4e-32 110.7 0.0 1.3 1 0 0 1 1 1 1 Maf-like protein Acetyltransf_7 PF13508.7 KOO24378.1 - 7.9e-08 32.6 0.0 1.4e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO24378.1 - 1.5e-07 31.7 0.0 2.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOO24378.1 - 5.8e-07 29.5 0.0 1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain zf-RING_14 PF17978.1 KOO24378.1 - 0.0092 16.4 0.2 0.018 15.5 0.2 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain CN_hydrolase PF00795.22 KOO24379.1 - 1e-10 41.4 0.0 1.6e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zf-RING_2 PF13639.6 KOO24379.1 - 2.1e-07 31.1 4.8 6.4e-07 29.6 4.8 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOO24379.1 - 0.00043 20.1 2.7 0.00098 19.0 2.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO24379.1 - 0.0022 17.8 5.5 0.016 15.1 5.7 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO24379.1 - 0.0022 18.0 2.6 0.0036 17.3 0.8 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOO24379.1 - 0.006 16.5 3.1 0.014 15.4 3.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain NrfD_2 PF14589.6 KOO24379.1 - 0.038 14.0 0.5 0.067 13.2 0.5 1.3 1 0 0 1 1 1 0 Polysulfide reductase WD40 PF00400.32 KOO24380.1 - 7.5e-26 89.9 13.4 0.00096 19.9 0.3 9.3 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO24380.1 - 0.0064 16.8 0.0 3.5 8.0 0.0 4.2 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_8 PF13833.6 KOO24380.1 - 0.0078 16.0 0.0 0.14 12.0 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair eIF2A PF08662.11 KOO24380.1 - 0.0087 16.0 0.0 0.71 9.7 0.0 2.7 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A HELP PF03451.14 KOO24380.1 - 0.0098 15.7 0.0 0.025 14.4 0.0 1.7 1 0 0 1 1 1 1 HELP motif EF-hand_6 PF13405.6 KOO24380.1 - 0.023 14.6 0.0 1.4 9.0 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain Ge1_WD40 PF16529.5 KOO24380.1 - 0.25 10.3 0.2 1.3 7.9 0.0 2.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein UQ_con PF00179.26 KOO24381.1 - 3.6e-08 33.2 0.0 1.3e-07 31.3 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO24381.1 - 0.0034 17.1 0.0 0.0071 16.0 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B Cnd1 PF12717.7 KOO24381.1 - 0.0065 16.5 0.0 0.021 14.9 0.0 1.8 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOO24381.1 - 0.031 14.5 2.3 2.1 8.8 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat RWD PF05773.22 KOO24381.1 - 0.053 13.8 0.0 0.096 13.0 0.0 1.4 1 0 0 1 1 1 0 RWD domain HEAT_2 PF13646.6 KOO24381.1 - 0.073 13.5 0.4 0.073 13.5 0.4 4.5 5 0 0 5 5 5 0 HEAT repeats TCR PF03638.15 KOO24382.1 - 5.5e-24 84.2 55.9 7e-13 48.7 23.8 2.2 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 KOO24382.1 - 0.5 10.5 47.5 1.1 9.4 22.3 2.8 2 1 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 Myb_DNA-binding PF00249.31 KOO24383.1 - 2e-12 47.1 0.1 2e-12 47.1 0.1 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO24383.1 - 2.1e-06 27.9 0.3 2.1e-06 27.9 0.3 1.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO24383.1 - 0.025 14.4 0.0 0.039 13.8 0.0 1.2 1 0 0 1 1 1 0 Myb DNA-binding like Acyltransferase PF01553.21 KOO24384.1 - 5.7e-22 77.8 0.0 1.5e-21 76.4 0.0 1.7 2 0 0 2 2 2 1 Acyltransferase Acyltransf_C PF16076.5 KOO24384.1 - 0.0013 18.8 0.0 0.0028 17.7 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus PAH PF02671.21 KOO24386.1 - 9.6e-38 128.1 17.8 8.4e-20 70.7 4.4 3.7 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3a_C PF16879.5 KOO24386.1 - 4.9e-36 124.9 9.0 3.9e-34 118.7 0.5 3.5 4 0 0 4 4 4 2 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 KOO24386.1 - 3.5e-29 100.8 0.0 7.5e-29 99.7 0.0 1.6 1 0 0 1 1 1 1 Sin3 family co-repressor RAC_head PF16717.5 KOO24386.1 - 0.091 13.7 0.7 0.49 11.4 0.1 2.5 2 0 0 2 2 2 0 Ribosome-associated complex head domain PhyH PF05721.13 KOO24388.1 - 0.00066 20.0 0.0 1.6 8.9 0.0 2.2 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Cupin_2 PF07883.11 KOO24388.1 - 0.08 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Cupin domain EF-hand_6 PF13405.6 KOO24389.1 - 7.1e-06 25.5 0.1 0.00021 21.0 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO24389.1 - 0.00026 20.3 0.1 0.00082 18.8 0.0 1.9 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO24389.1 - 0.00064 19.1 0.3 0.0023 17.3 0.2 1.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO24389.1 - 0.0013 19.1 0.0 0.0034 17.8 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO24389.1 - 0.0063 16.3 0.0 0.064 13.1 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair LRR_6 PF13516.6 KOO24389.1 - 0.015 15.3 0.2 0.1 12.7 0.1 2.5 2 0 0 2 2 2 0 Leucine Rich repeat EF-hand_1 PF00036.32 KOO24391.1 - 0.032 13.8 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 KOO24391.1 - 0.033 14.1 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 KOO24391.1 - 0.074 12.6 0.1 0.18 11.4 0.1 1.6 1 0 0 1 1 1 0 EF hand SNARE_assoc PF09335.11 KOO24394.1 - 4.9e-17 62.5 4.3 4.9e-17 62.5 4.3 2.3 1 1 0 2 2 2 1 SNARE associated Golgi protein NPR1_interact PF15699.5 KOO24394.1 - 0.064 13.9 0.8 0.15 12.7 0.8 1.5 1 0 0 1 1 1 0 NPR1 interacting Esterase_phd PF10503.9 KOO24395.1 - 0.0011 18.5 0.0 0.2 11.1 0.0 2.6 2 1 0 2 2 2 2 Esterase PHB depolymerase Laminin_G_3 PF13385.6 KOO24396.1 - 6.7e-20 71.8 0.0 4.4e-14 52.9 0.0 2.3 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 KOO24396.1 - 6.6e-06 26.7 0.0 1.1e-05 26.0 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 KOO24396.1 - 0.036 14.3 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain Ank_5 PF13857.6 KOO24398.1 - 6.4e-07 29.5 0.8 2e-06 28.0 0.5 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO24398.1 - 7.9e-06 26.4 0.1 1.6e-05 25.4 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO24398.1 - 1.9e-05 24.9 0.2 0.00021 21.6 0.2 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 KOO24398.1 - 8.5e-05 23.0 0.0 0.00021 21.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24398.1 - 0.00015 21.9 0.0 0.00064 20.0 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat Nop53 PF07767.11 KOO24398.1 - 0.44 9.9 15.2 0.76 9.1 15.2 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Guanylate_cyc PF00211.20 KOO24400.1 - 2.9e-19 69.4 0.0 3.1e-19 69.3 0.0 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Arginosuc_synth PF00764.19 KOO24400.1 - 0.003 16.9 0.0 0.0034 16.8 0.0 1.1 1 0 0 1 1 1 1 Arginosuccinate synthase Tudor_3 PF18115.1 KOO24401.1 - 0.14 12.0 0.1 0.27 11.1 0.1 1.4 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain DUF374 PF04028.13 KOO24401.1 - 1.2 8.7 6.1 0.9 9.1 1.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF374) Abhydrolase_4 PF08386.10 KOO24403.1 - 1.8e-11 44.0 0.0 4.5e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 KOO24403.1 - 0.00022 21.0 0.1 0.0044 16.7 0.0 2.5 3 0 0 3 3 3 1 alpha/beta hydrolase fold Ion_trans PF00520.31 KOO24404.1 - 2.1e-24 86.1 8.6 2.8e-24 85.7 8.6 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO24404.1 - 1.6e-09 37.6 7.2 1.6e-09 37.6 7.2 2.8 3 1 0 3 3 3 1 Ion channel cNMP_binding PF00027.29 KOO24404.1 - 0.0002 21.3 0.0 0.00039 20.4 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_6 PF13405.6 KOO24405.1 - 8.7e-66 212.3 29.5 8.6e-06 25.3 0.0 12.5 12 0 0 12 12 12 12 EF-hand domain EF-hand_1 PF00036.32 KOO24405.1 - 1.6e-65 211.8 39.7 2e-06 27.0 0.0 12.6 12 0 0 12 12 12 12 EF hand EF-hand_7 PF13499.6 KOO24405.1 - 5e-53 177.4 37.2 1.2e-09 38.4 0.5 7.7 5 2 2 7 7 7 7 EF-hand domain pair EF-hand_5 PF13202.6 KOO24405.1 - 7e-40 132.8 39.7 0.00059 19.2 0.3 12.3 12 0 0 12 12 12 10 EF hand EF-hand_8 PF13833.6 KOO24405.1 - 7e-36 121.9 40.4 4.4e-10 39.3 0.0 9.7 6 5 4 10 10 10 10 EF-hand domain pair Isochorismatase PF00857.20 KOO24405.1 - 4.8e-19 69.2 0.2 3.9e-17 63.0 0.2 3.5 2 0 0 2 2 2 1 Isochorismatase family EF-hand_11 PF08976.11 KOO24405.1 - 3.6e-05 24.6 0.0 9.9 7.1 0.0 4.0 3 1 0 3 3 3 2 EF-hand domain p25-alpha PF05517.12 KOO24405.1 - 0.00017 21.8 11.6 3.4 7.8 0.1 5.7 5 0 0 5 5 5 3 p25-alpha SPARC_Ca_bdg PF10591.9 KOO24405.1 - 0.0014 18.9 12.9 13 6.1 0.1 6.7 6 1 1 7 7 7 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO24405.1 - 0.0021 18.0 18.0 0.37 10.8 0.3 6.5 6 2 1 8 8 8 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 KOO24405.1 - 0.49 10.8 1.7 2e+02 2.4 0.0 5.1 6 0 0 6 6 4 0 EF-hand domain EF-hand_6 PF13405.6 KOO24406.1 - 3.6e-49 160.5 34.7 4e-07 29.4 0.5 8.3 8 0 0 8 8 8 8 EF-hand domain EF-hand_7 PF13499.6 KOO24406.1 - 3.5e-48 161.9 23.3 1.5e-12 47.8 1.2 4.2 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 KOO24406.1 - 2.5e-44 145.5 42.0 1.1e-05 24.6 0.7 8.4 8 0 0 8 8 8 8 EF hand EF-hand_5 PF13202.6 KOO24406.1 - 2.5e-40 134.2 44.3 1.5e-06 27.4 0.6 8.6 8 0 0 8 8 8 8 EF hand EF-hand_8 PF13833.6 KOO24406.1 - 9.6e-24 83.0 39.9 2.4e-08 33.7 0.8 8.3 5 3 3 8 8 8 6 EF-hand domain pair EF-hand_9 PF14658.6 KOO24406.1 - 2.9e-06 27.5 0.3 10 6.5 0.0 6.3 6 2 1 7 7 7 0 EF-hand domain EF-hand_14 PF17959.1 KOO24406.1 - 6.7e-06 26.4 5.1 31 5.0 0.0 7.0 5 3 1 6 6 6 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO24406.1 - 3.2e-05 24.2 8.2 14 6.0 0.0 6.7 1 1 4 7 7 7 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO24406.1 - 4.6e-05 23.4 15.1 0.32 10.9 2.5 6.9 4 2 2 6 6 6 2 Caleosin related protein Ad_Cy_reg PF16701.5 KOO24406.1 - 0.00015 21.6 0.8 7.2 6.3 0.0 4.3 4 0 0 4 4 4 1 Adenylate cyclase regulatory domain DUF2744 PF10910.8 KOO24406.1 - 0.00026 20.9 0.1 12 5.9 0.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2744) VCBS PF13517.6 KOO24406.1 - 0.00045 20.7 22.9 1.1 9.9 0.1 6.7 7 1 0 7 7 7 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Dockerin_1 PF00404.18 KOO24406.1 - 0.00066 19.8 7.3 5.4 7.3 0.1 5.8 4 3 2 6 6 6 1 Dockerin type I domain PCP PF02429.15 KOO24406.1 - 0.011 16.1 3.7 3.8 7.8 0.2 3.2 3 0 0 3 3 3 0 Peridinin-chlorophyll A binding protein PI-PLC-Y PF00387.19 KOO24406.1 - 0.014 15.7 0.7 14 6.1 0.0 3.7 4 0 0 4 4 4 0 Phosphatidylinositol-specific phospholipase C, Y domain MukF_M PF17192.4 KOO24406.1 - 0.079 12.7 1.5 25 4.5 0.0 3.3 3 0 0 3 3 3 0 MukF middle domain Lipoprotein_10 PF03202.13 KOO24406.1 - 0.081 13.4 1.1 21 5.6 0.1 3.3 3 0 0 3 3 3 0 Putative mycoplasma lipoprotein, C-terminal region Barwin PF00967.17 KOO24406.1 - 0.17 11.7 10.4 16 5.4 0.0 5.1 5 3 2 7 7 7 0 Barwin family Phage_lysozyme PF00959.19 KOO24406.1 - 0.2 12.1 2.0 14 6.1 0.2 3.2 3 0 0 3 3 3 0 Phage lysozyme Toprim_2 PF13155.6 KOO24406.1 - 0.38 11.2 9.4 20 5.7 0.1 5.2 2 1 4 6 6 6 0 Toprim-like Cleaved_Adhesin PF07675.11 KOO24406.1 - 0.48 10.3 1.9 49 3.8 0.0 4.3 6 0 0 6 6 6 0 Cleaved Adhesin Domain DUF5640 PF18692.1 KOO24406.1 - 1.7 8.7 13.9 47 4.1 0.0 6.2 7 0 0 7 7 7 0 Family of unknown function (DUF5640) EF-hand_4 PF12763.7 KOO24406.1 - 1.8 8.6 14.9 14 5.7 0.0 5.3 8 0 0 8 8 5 0 Cytoskeletal-regulatory complex EF hand Fringe PF02434.16 KOO24408.1 - 0.068 12.6 0.0 0.27 10.6 0.0 1.8 2 0 0 2 2 2 0 Fringe-like BT1 PF03092.16 KOO24410.1 - 3.3e-10 38.8 12.7 2.9e-07 29.1 1.0 3.1 3 0 0 3 3 3 3 BT1 family Nodulin-like PF06813.13 KOO24413.1 - 3.4e-08 33.3 3.3 0.0025 17.4 0.3 2.6 1 1 1 2 2 2 2 Nodulin-like C2 PF00168.30 KOO24414.1 - 8.2e-09 35.7 0.0 1.6e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain PSII_BNR PF14870.6 KOO24415.1 - 2.3e-114 381.7 0.2 2.8e-114 381.4 0.2 1.1 1 0 0 1 1 1 1 Photosynthesis system II assembly factor YCF48 BNR PF02012.20 KOO24415.1 - 4.8e-08 31.8 6.7 1.9 8.8 0.1 4.9 4 0 0 4 4 4 4 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KOO24415.1 - 0.00022 20.1 0.0 0.55 8.9 0.0 3.1 2 1 1 3 3 3 2 Sortilin, neurotensin receptor 3, DUF4185 PF13810.6 KOO24415.1 - 0.0027 17.0 0.1 1.9 7.6 0.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4185) Got1 PF04178.12 KOO24416.1 - 0.0013 19.1 5.3 0.0023 18.4 5.3 1.4 1 0 0 1 1 1 1 Got1/Sft2-like family DHQ_synthase PF01761.20 KOO24417.1 - 3.2e-61 206.8 0.0 4.7e-61 206.2 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 KOO24417.1 - 3.8e-07 30.1 0.0 6.4e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase TPR_2 PF07719.17 KOO24419.1 - 4.8e-16 57.5 0.7 0.00045 20.1 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO24419.1 - 6.5e-15 54.2 0.0 0.001 18.8 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO24419.1 - 1.3e-09 38.2 5.6 1.5e-06 28.4 0.1 4.5 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO24419.1 - 8.3e-09 36.0 3.7 5.1e-05 23.8 0.1 4.4 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO24419.1 - 1.8e-08 33.9 1.0 0.057 13.6 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO24419.1 - 6.4e-08 32.1 1.1 0.023 14.7 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO24419.1 - 7.5e-08 32.6 12.1 1.5 9.9 0.0 5.4 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO24419.1 - 2.2e-07 31.3 1.4 0.0037 17.7 0.2 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO24419.1 - 2.3e-05 24.0 0.1 1.4 8.7 0.0 4.1 4 0 0 4 4 4 2 TPR repeat TPR_10 PF13374.6 KOO24419.1 - 2.7e-05 23.9 9.9 0.027 14.3 0.1 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO24419.1 - 0.00017 22.0 6.4 1.2 10.0 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat DnaJ_C PF01556.18 KOO24421.1 - 9.3e-40 136.1 0.0 1.3e-39 135.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOO24421.1 - 3.2e-24 84.8 0.2 4.8e-24 84.3 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOO24421.1 - 7.3e-12 45.5 17.8 1.3e-11 44.7 17.8 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KOO24421.1 - 0.0091 15.9 2.5 0.0091 15.9 2.5 2.7 1 1 1 2 2 2 1 Tryptophan RNA-binding attenuator protein inhibitory protein DZR PF12773.7 KOO24421.1 - 0.05 13.6 6.9 0.17 11.9 7.0 1.8 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 KOO24421.1 - 0.44 10.6 5.4 0.77 9.8 5.4 1.4 1 0 0 1 1 1 0 zinc-ribbons HypA PF01155.19 KOO24421.1 - 0.97 9.5 8.9 0.41 10.7 1.5 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ISL3 PF14690.6 KOO24421.1 - 4.8 7.9 6.2 57 4.5 2.0 3.5 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 NHL PF01436.21 KOO24422.1 - 5.5e-31 105.0 12.2 2.3e-06 27.4 0.0 6.3 7 0 0 7 7 7 5 NHL repeat DUF5128 PF17170.4 KOO24422.1 - 2e-05 24.0 0.0 6.5e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 6-bladed beta-propeller SGL PF08450.12 KOO24422.1 - 2.6e-05 23.9 0.0 0.021 14.4 0.0 2.9 3 0 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 KOO24422.1 - 0.00065 19.1 0.0 0.0019 17.6 0.0 1.7 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller TolB_like PF15869.5 KOO24422.1 - 0.00079 18.7 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 TolB-like 6-blade propeller-like PQQ_3 PF13570.6 KOO24422.1 - 0.0083 16.6 8.0 11 6.7 0.0 5.6 6 0 0 6 6 6 1 PQQ-like domain F-box-like PF12937.7 KOO24422.1 - 0.021 14.7 0.1 0.049 13.5 0.1 1.7 1 0 0 1 1 1 0 F-box-like LVIVD PF08309.11 KOO24422.1 - 0.12 11.8 0.0 44 3.5 0.0 3.6 4 0 0 4 4 4 0 LVIVD repeat DUF1413 PF07205.11 KOO24423.1 - 0.18 11.9 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1413) EF-hand_1 PF00036.32 KOO24424.1 - 1.1e-12 46.5 0.2 7.5e-05 22.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO24424.1 - 8.9e-12 44.7 0.4 7.1e-11 41.8 0.1 2.5 3 0 0 3 3 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO24424.1 - 3.7e-10 38.9 0.1 4.2e-06 26.3 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain Ank_2 PF12796.7 KOO24424.1 - 7.4e-10 39.3 0.4 5.5e-09 36.5 0.2 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) EF-hand_7 PF13499.6 KOO24424.1 - 2.4e-09 37.5 0.0 1e-08 35.5 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO24424.1 - 1.7e-08 33.6 0.8 0.00025 20.4 0.2 2.7 2 0 0 2 2 2 2 EF hand Ank_4 PF13637.6 KOO24424.1 - 2.3e-08 34.4 0.3 0.00095 19.7 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO24424.1 - 3.8e-08 33.5 0.3 0.0019 18.5 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24424.1 - 5.9e-07 29.3 0.2 0.099 13.3 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KOO24424.1 - 8.8e-06 25.9 3.4 0.00087 19.6 0.1 4.1 4 0 0 4 4 4 1 Ankyrin repeat ART PF01129.18 KOO24424.1 - 0.00013 21.3 0.0 0.00024 20.5 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO24424.1 - 0.00016 21.1 0.0 0.00063 19.1 0.0 2.0 2 1 0 2 2 2 1 ADP-ribosyltransferase exoenzyme EF-hand_4 PF12763.7 KOO24424.1 - 0.023 14.7 0.0 1.4 8.9 0.0 2.6 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF2431 PF10354.9 KOO24425.1 - 1.3e-47 162.2 0.0 1.7e-47 161.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Methyltr_RsmB-F PF01189.17 KOO24425.1 - 0.012 15.3 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F TPR_10 PF13374.6 KOO24426.1 - 5.9e-40 134.1 10.7 2.3e-13 49.5 0.1 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOO24426.1 - 2.6e-33 114.1 6.0 7.9e-16 58.1 0.2 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO24426.1 - 1e-10 40.9 6.1 0.064 13.3 0.1 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO24426.1 - 1.9e-10 40.0 5.8 0.0031 17.5 0.1 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO24426.1 - 5.8e-10 38.6 0.9 0.01 16.0 0.0 4.0 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO24426.1 - 8.4e-10 38.1 1.1 0.025 14.4 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO24426.1 - 8.3e-08 32.0 1.5 0.0013 18.2 0.2 2.3 1 1 1 2 2 2 2 MalT-like TPR region TPR_4 PF07721.14 KOO24426.1 - 8e-05 22.9 7.9 0.082 13.6 0.1 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO24426.1 - 0.00012 22.2 0.2 3.2 8.3 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO24426.1 - 0.00041 20.9 15.8 0.00079 20.0 1.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO24426.1 - 0.0017 18.8 10.3 0.02 15.4 1.3 3.8 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO24426.1 - 0.032 15.0 20.9 0.75 10.8 0.1 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat Pentapeptide_4 PF13599.6 KOO24426.1 - 0.058 13.6 0.0 0.18 12.0 0.0 1.8 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) AbiEi_4 PF13338.6 KOO24426.1 - 0.11 12.6 0.8 1.4 9.1 0.0 3.4 3 0 0 3 3 3 0 Transcriptional regulator, AbiEi antitoxin TPR_11 PF13414.6 KOO24426.1 - 0.68 9.7 2.9 5.3 6.8 0.0 3.0 3 0 0 3 3 3 0 TPR repeat TPR_6 PF13174.6 KOO24426.1 - 3.2 8.6 6.7 22 6.0 0.1 3.7 4 0 0 4 4 2 0 Tetratricopeptide repeat Fasciclin PF02469.22 KOO24428.1 - 4.2e-33 114.3 0.0 7.9e-33 113.4 0.0 1.5 1 0 0 1 1 1 1 Fasciclin domain S1 PF00575.23 KOO24428.1 - 8.7e-30 102.9 7.2 4.8e-17 62.1 3.1 2.6 1 1 1 2 2 2 2 S1 RNA binding domain S1_2 PF13509.6 KOO24428.1 - 3.9e-05 23.6 0.1 0.064 13.3 0.1 2.9 1 1 1 2 2 2 2 S1 domain RNase_II_C_S1 PF18614.1 KOO24428.1 - 0.00086 19.2 0.1 0.0048 16.8 0.1 2.4 1 0 0 1 1 1 1 RNase II-type exonuclease C-terminal S1 domain CSD PF00313.22 KOO24428.1 - 0.0043 16.9 2.7 0.039 13.8 1.1 2.4 1 1 1 2 2 2 1 'Cold-shock' DNA-binding domain CRAL_TRIO PF00650.20 KOO24429.1 - 1.2e-26 93.3 0.0 1.7e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOO24429.1 - 0.0021 18.2 0.3 0.0044 17.2 0.3 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain HIP1_clath_bdg PF16515.5 KOO24429.1 - 0.02 15.5 0.9 0.037 14.6 0.9 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cyt-b5 PF00173.28 KOO24430.1 - 2.8e-13 49.8 0.0 6e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PsaD PF02531.16 KOO24431.1 - 8.4e-06 25.3 0.0 1e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 PsaD Apelin PF15360.6 KOO24431.1 - 1.1 9.8 4.4 2.4 8.8 3.2 2.1 2 0 0 2 2 2 0 APJ endogenous ligand OTU PF02338.19 KOO24432.1 - 2e-23 83.3 0.7 4.6e-23 82.1 0.1 1.8 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 KOO24432.1 - 6e-06 25.9 0.0 0.0028 17.2 0.0 2.4 2 0 0 2 2 2 2 Peptidase C65 Otubain Pkinase PF00069.25 KOO24433.1 - 3.3e-09 36.5 0.0 4.4e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24433.1 - 0.00024 20.5 0.0 0.0029 16.9 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase UAA PF08449.11 KOO24434.1 - 7.5e-42 143.6 17.8 7.5e-42 143.6 17.8 2.3 2 0 0 2 2 2 2 UAA transporter family TPT PF03151.16 KOO24434.1 - 0.27 10.5 27.8 0.035 13.4 3.9 2.6 2 0 0 2 2 2 0 Triose-phosphate Transporter family C2 PF00168.30 KOO24435.1 - 7.8e-62 206.0 0.0 5.8e-14 52.2 0.1 9.8 9 1 0 9 9 9 7 C2 domain FerI PF08151.12 KOO24435.1 - 0.0007 19.6 0.0 0.0019 18.2 0.0 1.7 1 0 0 1 1 1 1 FerI (NUC094) domain Ferlin_C PF16165.5 KOO24435.1 - 0.0071 16.3 0.0 0.02 14.8 0.0 1.7 1 0 0 1 1 1 1 Ferlin C-terminus DUF2475 PF10629.9 KOO24436.1 - 6.6e-06 26.3 1.5 0.012 15.8 0.2 3.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) Cadherin_tail PF15974.5 KOO24437.1 - 0.078 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region Med23 PF11573.8 KOO24437.1 - 0.35 8.5 0.1 0.45 8.1 0.1 1.0 1 0 0 1 1 1 0 Mediator complex subunit 23 LRR_6 PF13516.6 KOO24438.1 - 6.2e-14 50.8 2.1 0.0014 18.5 0.1 5.3 5 0 0 5 5 5 3 Leucine Rich repeat LRR_8 PF13855.6 KOO24438.1 - 0.0036 17.0 2.6 2.3 8.0 0.4 4.3 3 1 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 KOO24438.1 - 0.0071 16.7 1.5 53 4.9 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO24438.1 - 0.077 13.5 6.3 1.1 9.8 1.1 4.2 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Hydrolase_4 PF12146.8 KOO24440.1 - 7.9e-13 48.2 0.3 4.1e-10 39.3 0.3 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO24440.1 - 7.3e-05 22.5 0.1 0.00011 22.0 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 KOO24440.1 - 0.0085 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 KOO24440.1 - 0.016 14.8 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) RAP80_UIM PF18282.1 KOO24440.1 - 0.03 14.1 0.2 4.2 7.2 0.1 2.4 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif Glyco_transf_8 PF01501.20 KOO24442.1 - 0.0016 18.0 0.0 0.0048 16.5 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 8 Ank_2 PF12796.7 KOO24443.1 - 3.8e-26 91.5 3.7 8.8e-13 48.7 0.2 3.9 2 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO24443.1 - 2.5e-19 69.4 9.1 6.9e-06 26.5 0.0 5.3 1 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24443.1 - 5.9e-18 63.1 3.5 0.0023 18.3 0.1 5.9 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 KOO24443.1 - 4.1e-14 52.5 6.5 0.00089 19.5 0.1 5.2 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO24443.1 - 2.7e-13 49.7 11.4 0.0011 19.4 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Cgr1 PF03879.14 KOO24444.1 - 1.1e-09 38.6 23.6 1.4e-09 38.2 23.6 1.0 1 0 0 1 1 1 1 Cgr1 family TPR_17 PF13431.6 KOO24445.1 - 7.7e-08 32.2 0.7 0.016 15.6 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO24445.1 - 0.13 13.2 18.6 1 10.4 0.3 5.2 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO24445.1 - 2.1 8.9 13.5 6.2 7.4 0.3 3.9 2 1 1 4 4 4 0 Tetratricopeptide repeat Amidoligase_2 PF12224.8 KOO24449.1 - 9.8e-07 28.7 0.3 0.00078 19.2 0.0 2.3 2 0 0 2 2 2 2 Putative amidoligase enzyme TIG PF01833.24 KOO24450.1 - 3.8e-15 55.7 0.1 0.00045 20.2 0.1 3.9 3 1 1 4 4 4 3 IPT/TIG domain EP400_N PF15790.5 KOO24451.1 - 0.23 10.3 5.3 0.37 9.6 5.3 1.2 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal VCBS PF13517.6 KOO24452.1 - 1.9e-95 313.4 119.4 2.5e-13 50.4 2.6 10.5 1 1 9 10 10 10 10 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO24452.1 - 1.4e-46 156.2 113.1 3.2e-05 24.0 1.9 11.6 11 0 0 11 11 11 11 FG-GAP repeat Ephrin_rec_like PF07699.13 KOO24452.1 - 1.5e-12 47.0 63.2 3.9e-07 29.7 4.3 8.5 3 2 4 7 7 7 4 Putative ephrin-receptor like Dockerin_1 PF00404.18 KOO24452.1 - 9.1e-06 25.8 30.1 43 4.4 0.0 11.0 11 0 0 11 11 11 1 Dockerin type I domain Mito_carr PF00153.27 KOO24453.1 - 9.4e-37 124.8 1.7 1e-16 60.6 0.0 4.1 3 1 1 4 4 4 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOO24453.1 - 0.0095 15.1 0.0 0.08 12.1 0.0 2.0 2 0 0 2 2 2 1 Gammaproteobacterial serine protease DUF4682 PF15733.5 KOO24454.1 - 0.3 11.7 0.3 95 3.6 0.0 3.3 1 1 1 3 3 3 0 Domain of unknown function (DUF4682) SET PF00856.28 KOO24456.1 - 2.9e-05 24.5 0.0 7.6e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 SET domain Gly-zipper_OmpA PF13436.6 KOO24456.1 - 7.6 6.4 9.0 0.15 11.9 0.7 2.5 2 0 0 2 2 2 0 Glycine-zipper domain TIG PF01833.24 KOO24457.1 - 5.9e-06 26.3 1.1 0.19 11.8 0.1 3.5 3 0 0 3 3 3 2 IPT/TIG domain Galactosyl_T PF01762.21 KOO24458.1 - 2.4e-06 27.5 0.0 0.07 12.9 0.0 2.1 2 0 0 2 2 2 2 Galactosyltransferase cNMPbd_u2 PF16643.5 KOO24459.1 - 0.14 12.6 0.1 0.14 12.6 0.1 3.0 2 1 0 3 3 3 0 Unstructured region on cNMP-binding protein Arm PF00514.23 KOO24460.1 - 2.1e-63 208.6 30.8 7.1e-09 35.4 0.4 8.8 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO24460.1 - 2e-08 34.1 7.8 0.0037 17.3 0.0 5.1 2 2 4 6 6 6 3 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO24460.1 - 0.00072 19.1 1.3 0.024 14.1 0.3 2.9 1 1 2 3 3 3 2 Armadillo-like HEAT_EZ PF13513.6 KOO24460.1 - 0.0021 18.5 26.6 0.019 15.5 1.5 5.7 2 1 4 6 6 6 6 HEAT-like repeat DUF4726 PF15855.5 KOO24460.1 - 0.0049 17.1 0.7 0.012 15.8 0.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4726) SNAD2 PF18745.1 KOO24460.1 - 0.0088 15.8 0.2 62 3.2 0.0 4.8 3 3 2 5 5 5 0 Secreted Novel AID/APOBEC-like Deaminase 2 Ubie_methyltran PF01209.18 KOO24461.1 - 2e-83 279.3 0.0 2.3e-83 279.1 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 KOO24461.1 - 2e-18 66.9 0.0 1.9e-17 63.7 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO24461.1 - 2.8e-17 63.2 0.0 1.6e-16 60.7 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO24461.1 - 2.7e-11 43.5 0.0 4.5e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO24461.1 - 1.6e-10 41.6 0.0 4.1e-10 40.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO24461.1 - 2.3e-08 34.0 0.0 3.4e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KOO24461.1 - 1e-06 28.8 0.0 1.6e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 KOO24461.1 - 0.016 13.7 0.1 0.024 13.2 0.1 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 KOO24461.1 - 0.081 12.5 0.0 3.6 7.1 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase small domain NodS PF05401.11 KOO24461.1 - 0.13 11.8 0.0 0.42 10.2 0.0 1.8 2 0 0 2 2 2 0 Nodulation protein S (NodS) NNMT_PNMT_TEMT PF01234.17 KOO24461.1 - 0.14 11.3 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_2 PF00891.18 KOO24461.1 - 0.14 11.4 0.0 8.1 5.7 0.0 2.4 2 0 0 2 2 2 0 O-methyltransferase domain AMPK1_CBM PF16561.5 KOO24462.1 - 9.2e-32 109.1 0.0 1.8e-31 108.2 0.0 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 KOO24462.1 - 2.5e-08 34.1 0.3 5.3e-08 33.0 0.3 1.6 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain ADPrib_exo_Tox PF03496.14 KOO24463.1 - 8.1e-08 31.8 0.0 5e-07 29.3 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO24463.1 - 1.7e-05 24.2 0.0 2.8e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase UBX PF00789.20 KOO24464.1 - 3.3e-06 27.2 0.0 4.8e-06 26.7 0.0 1.4 1 1 0 1 1 1 1 UBX domain Peptidase_S28 PF05577.12 KOO24465.1 - 1.3e-86 291.1 0.0 1.6e-86 290.8 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 KOO24465.1 - 0.038 12.7 0.0 0.23 10.1 0.0 1.9 2 0 0 2 2 2 0 PS-10 peptidase S37 Peptidase_S9 PF00326.21 KOO24465.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family LRR_8 PF13855.6 KOO24466.1 - 4.7e-12 45.5 7.8 7.5e-07 28.8 2.0 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KOO24466.1 - 2.3e-07 31.0 10.0 0.0017 18.7 1.4 3.9 1 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO24466.1 - 0.017 15.6 6.1 6.4 7.7 0.0 4.6 4 1 0 4 4 4 0 Leucine Rich Repeat Methyltransf_23 PF13489.6 KOO24467.1 - 0.0017 18.2 0.0 0.0029 17.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO24467.1 - 0.02 15.6 0.0 0.039 14.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 KOO24467.1 - 0.12 13.0 0.0 0.3 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 KOO24467.1 - 0.13 11.9 0.0 0.76 9.3 0.0 2.0 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW PT-VENN PF04829.13 KOO24467.1 - 1.6 8.9 6.4 3.3 7.9 6.4 1.4 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif Ribosomal_S20p PF01649.18 KOO24468.1 - 4.5e-20 72.1 7.0 6.7e-20 71.5 7.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S20 PhrC_PhrF PF11131.8 KOO24468.1 - 0.42 10.2 3.4 2.4 7.8 3.0 2.3 1 1 1 2 2 2 0 Rap-phr extracellular signalling LapA_dom PF06305.11 KOO24468.1 - 5.7 6.8 6.3 1.9 8.3 1.7 2.5 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Ras PF00071.22 KOO24469.1 - 3e-53 179.7 0.0 3.5e-53 179.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO24469.1 - 3.6e-32 111.1 0.0 7.3e-32 110.1 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO24469.1 - 1.4e-11 44.1 0.0 1.7e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KOO24469.1 - 0.0018 18.2 0.0 0.11 12.4 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 KOO24469.1 - 0.0047 17.0 0.0 0.018 15.1 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 KOO24469.1 - 0.066 12.6 0.0 0.19 11.2 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KOO24469.1 - 0.076 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KOO24469.1 - 0.13 11.6 0.0 0.24 10.7 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 KOO24469.1 - 0.15 11.8 0.0 0.35 10.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain UFD1 PF03152.14 KOO24470.1 - 1.3e-66 223.4 0.0 1.5e-66 223.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 PAH PF02671.21 KOO24473.1 - 1.4e-17 63.6 1.2 2.1e-17 63.0 1.2 1.3 1 0 0 1 1 1 1 Paired amphipathic helix repeat XendoU PF09412.10 KOO24473.1 - 0.072 12.3 0.1 0.089 12.0 0.1 1.1 1 0 0 1 1 1 0 Endoribonuclease XendoU UDPGP PF01704.18 KOO24474.1 - 2.4e-11 42.9 0.0 7e-11 41.4 0.0 1.6 2 0 0 2 2 2 1 UTP--glucose-1-phosphate uridylyltransferase EF-hand_1 PF00036.32 KOO24475.1 - 8e-25 84.5 7.3 1.9e-06 27.0 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO24475.1 - 4e-22 76.2 6.2 9.1e-05 22.1 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO24475.1 - 2.5e-19 69.5 5.2 2.1e-09 37.7 0.5 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO24475.1 - 2.6e-19 67.8 0.9 0.0015 17.9 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO24475.1 - 4.5e-15 55.2 2.8 5.5e-07 29.3 0.0 3.6 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO24475.1 - 4.9e-09 36.5 4.4 0.0015 18.8 0.7 2.6 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO24475.1 - 9.1e-06 25.6 1.7 0.0023 17.8 0.2 2.8 2 2 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO24475.1 - 0.00063 19.6 1.7 0.55 10.1 0.1 3.1 2 2 2 4 4 4 2 EF hand DUF5580 PF17743.1 KOO24475.1 - 0.0018 16.9 0.0 0.0038 15.8 0.0 1.5 1 1 1 2 2 2 1 Family of unknown function (DUF5580) PBP_GOBP PF01395.22 KOO24475.1 - 0.011 15.9 2.8 0.16 12.1 2.1 2.4 2 1 0 2 2 2 0 PBP/GOBP family PMBR PF09373.10 KOO24475.1 - 0.05 13.8 0.0 1.1 9.5 0.0 2.9 2 0 0 2 2 2 0 Pseudomurein-binding repeat DUF4113 PF13438.6 KOO24475.1 - 0.17 12.0 1.8 49 4.1 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4113) Toprim PF01751.22 KOO24475.1 - 1.4 9.2 4.2 3 8.1 1.6 2.6 1 1 1 2 2 2 0 Toprim domain GLTSCR1 PF15249.6 KOO24475.1 - 5 7.6 6.4 21 5.6 1.2 2.6 2 1 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein DUF2870 PF11069.8 KOO24477.1 - 1.7e-36 124.5 2.0 2.8e-36 123.8 2.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) Pentapeptide_4 PF13599.6 KOO24478.1 - 2.3e-46 155.8 0.0 5.3e-05 23.3 0.0 13.5 5 3 7 14 14 14 13 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.18 KOO24478.1 - 2e-06 27.8 49.5 1.8 8.4 0.0 19.5 11 6 8 22 22 22 3 Ribosomal protein L13e Ntox33 PF15533.6 KOO24478.1 - 0.00092 19.6 18.3 1e+02 3.5 0.0 13.6 10 5 4 16 16 16 0 Bacterial toxin 33 Acetyltransf_11 PF13720.6 KOO24478.1 - 0.0076 16.7 0.6 69 4.0 0.0 6.6 6 1 0 6 6 6 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Arteri_GP4 PF02497.15 KOO24478.1 - 0.059 13.5 0.2 31 4.7 0.0 4.5 4 1 1 5 5 5 0 Arterivirus glycoprotein XK-related PF09815.9 KOO24478.1 - 3.3 6.7 14.7 12 4.9 14.7 1.8 1 1 0 1 1 1 0 XK-related protein HEAT PF02985.22 KOO24479.1 - 3.8e-14 51.6 25.2 0.04 14.2 0.0 10.3 10 1 0 10 10 10 6 HEAT repeat HEAT_2 PF13646.6 KOO24479.1 - 3e-12 46.8 19.3 0.0025 18.1 0.2 7.1 4 2 2 6 6 6 4 HEAT repeats DUF2063 PF09836.9 KOO24479.1 - 0.13 12.5 0.0 0.41 10.9 0.0 1.8 1 0 0 1 1 1 0 Putative DNA-binding domain Lipase_3 PF01764.25 KOO24480.1 - 2.4e-09 37.2 0.0 5.1e-09 36.1 0.0 1.5 1 1 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 KOO24480.1 - 1.2e-05 24.7 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 WW PF00397.26 KOO24480.1 - 1.9e-05 24.7 1.6 2.9e-05 24.0 1.6 1.3 1 0 0 1 1 1 1 WW domain Abhydrolase_6 PF12697.7 KOO24480.1 - 0.00031 21.4 13.6 0.00031 21.4 13.6 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 KOO24480.1 - 0.0082 16.3 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 KOO24480.1 - 0.18 11.5 0.1 0.31 10.7 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein Pkinase PF00069.25 KOO24481.1 - 2.5e-52 177.8 0.0 3e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24481.1 - 1.1e-19 70.8 0.0 1.7e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO24481.1 - 0.00045 19.6 0.0 0.00069 19.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO24481.1 - 0.00051 19.5 0.0 0.0043 16.4 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO24481.1 - 0.0012 17.7 0.0 0.0018 17.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 KOO24481.1 - 0.0023 17.6 0.0 0.013 15.2 0.0 1.9 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KOO24481.1 - 0.0047 16.9 0.8 0.018 15.0 0.0 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 KOO24481.1 - 0.051 13.2 0.0 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 RIO1 family YrbL-PhoP_reg PF10707.9 KOO24481.1 - 0.22 11.1 0.0 0.31 10.5 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL ASH PF15780.5 KOO24482.1 - 3.7e-38 129.7 0.5 0.0044 17.2 0.0 16.3 17 1 0 17 17 17 9 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 KOO24482.1 - 6.9e-10 39.0 1.0 0.016 15.3 0.1 6.9 8 0 0 8 8 8 2 Flagellar-associated PapD-like TMEM131_like PF12371.8 KOO24482.1 - 2.6e-08 34.0 4.4 0.074 13.3 0.0 7.6 10 0 0 10 10 10 3 Transmembrane protein 131-like RRM_1 PF00076.22 KOO24483.1 - 2.2e-11 43.4 0.0 4e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) K_channel_TID PF07941.11 KOO24483.1 - 0.0073 16.7 8.6 0.02 15.3 8.6 1.7 1 0 0 1 1 1 1 Potassium channel Kv1.4 tandem inactivation domain RRM_7 PF16367.5 KOO24483.1 - 0.013 15.6 0.0 0.03 14.4 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif UCH PF00443.29 KOO24484.1 - 8e-37 127.1 0.0 1.1e-36 126.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 KOO24484.1 - 1e-15 58.1 0.0 2e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 KOO24484.1 - 1.9e-06 27.7 0.0 2.8e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.6 KOO24484.1 - 6.8e-05 22.8 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain USP7_C2 PF14533.6 KOO24484.1 - 0.00053 19.8 0.0 0.86 9.3 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-specific protease C-terminal Inositol_P PF00459.25 KOO24485.1 - 4.8e-22 78.8 0.1 8.5e-22 77.9 0.1 1.4 1 0 0 1 1 1 1 Inositol monophosphatase family TruD PF01142.18 KOO24486.1 - 2e-23 82.9 0.0 3.7e-23 82.0 0.0 1.3 1 1 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) LRR_5 PF13306.6 KOO24489.1 - 4.9e-94 311.0 0.0 7.7e-35 119.6 0.0 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO24489.1 - 3.5e-20 71.5 0.0 0.011 15.5 0.0 8.0 2 1 9 11 11 11 10 Leucine rich repeat TruD PF01142.18 KOO24490.1 - 3.2e-06 26.2 0.0 3.5e-06 26.1 0.0 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) OTU PF02338.19 KOO24491.1 - 1.3e-09 38.7 0.0 4e-09 37.0 0.0 1.9 1 0 0 1 1 1 1 OTU-like cysteine protease DUF3584 PF12128.8 KOO24491.1 - 0.0051 14.4 7.9 0.0074 13.9 7.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Peptidase_C65 PF10275.9 KOO24491.1 - 0.013 15.0 3.7 0.72 9.3 0.0 2.6 3 0 0 3 3 3 0 Peptidase C65 Otubain ATG16 PF08614.11 KOO24491.1 - 0.037 14.2 16.7 0.1 12.8 16.7 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF948 PF06103.11 KOO24491.1 - 0.039 14.2 0.8 0.22 11.8 0.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TSNAXIP1_N PF15739.5 KOO24491.1 - 0.079 13.3 2.4 0.17 12.2 1.7 2.0 1 1 0 1 1 1 0 Translin-associated factor X-interacting N-terminus IFT57 PF10498.9 KOO24491.1 - 0.23 10.4 2.1 0.35 9.8 1.4 1.6 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 HMMR_N PF15905.5 KOO24491.1 - 0.33 10.4 6.7 0.58 9.6 6.7 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Cnn_1N PF07989.11 KOO24491.1 - 0.47 10.6 2.6 3.6 7.8 1.8 2.5 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Spc7 PF08317.11 KOO24491.1 - 0.7 8.7 14.7 2.4 7.0 12.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Fez1 PF06818.15 KOO24491.1 - 0.87 10.0 13.5 0.25 11.8 8.4 2.2 1 1 1 2 2 2 0 Fez1 APG6_N PF17675.1 KOO24491.1 - 0.89 10.1 16.4 0.024 15.2 7.3 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region HAUS-augmin3 PF14932.6 KOO24491.1 - 1.1 8.8 12.1 1.8 8.1 12.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 CENP-F_leu_zip PF10473.9 KOO24491.1 - 2 8.4 10.2 3.7 7.6 9.3 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.8 KOO24491.1 - 3.4 7.9 10.3 2.7 8.2 3.4 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Snapin_Pallidin PF14712.6 KOO24491.1 - 4.6 7.7 8.2 20 5.7 0.5 2.8 1 1 1 2 2 2 0 Snapin/Pallidin Arm PF00514.23 KOO24493.1 - 1.7e-68 224.7 60.0 9.2e-06 25.5 0.5 22.9 23 1 0 23 23 23 14 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO24493.1 - 2.7e-16 59.4 11.9 0.00033 20.6 0.4 9.8 7 3 4 11 11 11 4 Spinocerebellar ataxia type 10 protein domain DUF5578 PF17741.1 KOO24493.1 - 1.3e-07 31.3 23.9 0.041 13.3 0.1 7.3 6 2 1 8 8 8 5 Family of unknown function (DUF5578) HEAT_EZ PF13513.6 KOO24493.1 - 3.7e-05 24.1 50.3 1 9.9 0.4 11.8 11 0 0 11 11 11 3 HEAT-like repeat V-ATPase_H_N PF03224.14 KOO24493.1 - 0.00022 20.6 1.2 1.8 7.8 0.0 4.4 3 2 1 4 4 4 1 V-ATPase subunit H Arm_2 PF04826.13 KOO24493.1 - 0.00029 20.4 12.6 10 5.5 0.0 7.3 5 2 4 9 9 9 2 Armadillo-like Adaptin_N PF01602.20 KOO24493.1 - 0.00062 18.4 7.9 1.1 7.7 0.0 5.7 4 1 3 7 7 7 2 Adaptin N terminal region UNC45-central PF11701.8 KOO24493.1 - 0.82 9.6 4.4 2.6 8.0 0.5 3.7 4 1 1 5 5 5 0 Myosin-binding striated muscle assembly central HEAT_2 PF13646.6 KOO24493.1 - 6.1 7.3 56.7 0.073 13.5 0.4 9.7 5 2 6 12 12 12 0 HEAT repeats HEAT PF02985.22 KOO24493.1 - 9 6.9 33.3 5.6 7.5 0.1 10.2 13 0 0 13 13 13 0 HEAT repeat Mis12 PF05859.12 KOO24494.1 - 7.8e-21 74.6 0.6 1.3e-20 73.8 0.6 1.4 1 0 0 1 1 1 1 Mis12 protein OHCU_decarbox PF09349.10 KOO24494.1 - 0.04 14.4 0.8 0.33 11.4 0.0 2.2 2 0 0 2 2 2 0 OHCU decarboxylase LMBR1 PF04791.16 KOO24494.1 - 0.084 11.8 0.1 0.096 11.6 0.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein H-kinase_dim PF02895.14 KOO24494.1 - 0.25 11.8 3.1 4.1 7.9 3.1 2.5 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain adh_short PF00106.25 KOO24495.1 - 1.6e-15 57.1 0.0 1.3e-11 44.3 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO24495.1 - 1.5e-10 41.1 0.0 2.8e-09 36.9 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Cyclin_N PF00134.23 KOO24496.1 - 1.5e-25 89.4 0.2 2.7e-25 88.5 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pkinase PF00069.25 KOO24496.1 - 1e-15 57.8 0.0 1.6e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Gly_transf_sug PF04488.15 KOO24496.1 - 1.2e-08 35.4 0.0 2.9e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Pkinase_Tyr PF07714.17 KOO24496.1 - 2.2e-05 23.9 0.0 4.7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase F-box-like PF12937.7 KOO24496.1 - 0.06 13.3 0.1 0.2 11.6 0.1 1.9 1 1 0 1 1 1 0 F-box-like ATP19 PF11022.8 KOO24497.1 - 0.19 12.1 5.0 0.32 11.4 0.1 2.8 2 1 0 2 2 2 0 ATP synthase subunit K YiaAB PF05360.14 KOO24497.1 - 0.55 10.5 4.2 11 6.4 0.6 2.3 2 0 0 2 2 2 0 yiaA/B two helix domain 2OG-FeII_Oxy_3 PF13640.6 KOO24498.1 - 1.1e-17 64.6 0.0 2.6e-17 63.5 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO24498.1 - 5.8e-08 33.3 0.0 1.1e-07 32.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PAF-AH_p_II PF03403.13 KOO24500.1 - 0.0037 15.8 0.0 0.0053 15.3 0.0 1.2 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase PF07224.11 KOO24500.1 - 0.011 14.7 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase DLH PF01738.18 KOO24500.1 - 0.033 13.8 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 KOO24500.1 - 0.083 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO24500.1 - 0.39 9.9 0.8 0.61 9.3 0.1 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 FAD_binding_4 PF01565.23 KOO24502.1 - 1.5e-10 41.0 0.1 2.6e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain SRP-alpha_N PF04086.13 KOO24503.1 - 0.26 11.2 5.8 0.31 10.9 5.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CBP_BcsO PF17037.5 KOO24503.1 - 0.45 10.6 5.9 0.59 10.3 5.9 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsO Spt5_N PF11942.8 KOO24503.1 - 0.53 11.3 13.1 0.09 13.8 6.0 2.6 1 1 1 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Pkinase_Tyr PF07714.17 KOO24504.1 - 3.4e-46 157.6 0.2 1.7e-40 139.0 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KOO24504.1 - 5.9e-45 153.7 0.0 1.6e-44 152.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO24504.1 - 0.00089 19.2 0.0 0.0017 18.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO24504.1 - 0.0048 15.9 0.0 0.0094 14.9 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain E1-E2_ATPase PF00122.20 KOO24505.1 - 1.7e-41 141.7 2.8 1.8e-41 141.6 0.8 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KOO24505.1 - 3.8e-37 128.6 0.1 7.3e-37 127.7 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOO24505.1 - 2.9e-05 24.0 0.2 0.0003 20.6 0.2 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ACP_syn_III_C PF08541.10 KOO24506.1 - 0.0035 17.5 0.0 0.0085 16.2 0.0 1.6 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal DUF3606 PF12244.8 KOO24506.1 - 0.015 15.2 0.0 2.6 8.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) DUF2120 PF09893.9 KOO24506.1 - 0.061 13.4 0.4 0.13 12.3 0.4 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) PIN_8 PF18476.1 KOO24506.1 - 1.5 8.6 6.3 2.4 8.0 6.3 1.5 1 1 0 1 1 1 0 PIN like domain EF-hand_5 PF13202.6 KOO24507.1 - 3.7e-05 23.0 0.1 8.7e-05 21.8 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO24507.1 - 4.4e-05 23.1 0.1 0.00011 21.8 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO24507.1 - 0.00014 21.2 0.0 0.00035 19.9 0.0 1.8 1 0 0 1 1 1 1 EF hand TPR_2 PF07719.17 KOO24507.1 - 0.00075 19.4 0.1 0.035 14.2 0.0 3.6 2 1 0 2 2 2 1 Tetratricopeptide repeat EF-hand_8 PF13833.6 KOO24507.1 - 0.0024 17.7 0.1 0.019 14.8 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 KOO24507.1 - 0.0025 18.2 0.1 0.0065 16.9 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair TPR_1 PF00515.28 KOO24507.1 - 0.0027 17.4 0.0 0.012 15.4 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO24507.1 - 0.025 15.4 4.2 0.078 13.8 0.1 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO24507.1 - 0.051 13.8 0.0 0.31 11.4 0.0 2.5 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO24507.1 - 0.089 12.9 6.9 0.095 12.8 0.0 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat EF-hand_5 PF13202.6 KOO24508.1 - 0.0001 21.6 0.0 0.00019 20.8 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO24508.1 - 0.0021 17.5 0.0 0.0043 16.5 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO24508.1 - 0.0094 15.8 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO24508.1 - 0.17 12.3 0.0 0.3 11.6 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair CMAS PF02353.20 KOO24510.1 - 1.1e-66 225.0 0.2 1.3e-66 224.7 0.2 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 KOO24510.1 - 9.7e-14 51.9 0.1 1.8e-13 51.0 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO24510.1 - 1e-13 51.7 0.0 2e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO24510.1 - 1e-10 41.6 0.0 1.7e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO24510.1 - 6.5e-10 39.1 0.0 1.1e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO24510.1 - 5.8e-08 33.4 0.0 1.1e-07 32.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 KOO24510.1 - 8.9e-06 25.4 0.2 9.6e-05 22.0 0.0 2.1 2 0 0 2 2 2 1 Histone methylation protein DOT1 MTS PF05175.14 KOO24510.1 - 2.2e-05 24.0 0.0 4.3e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 KOO24510.1 - 0.0043 16.7 0.0 0.007 16.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 KOO24510.1 - 0.019 14.8 0.0 0.038 13.7 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 KOO24510.1 - 0.094 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 KOO24510.1 - 0.095 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 KOO24510.1 - 0.1 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 KOO24510.1 - 0.15 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MORN PF02493.20 KOO24511.1 - 0.038 13.9 4.1 0.83 9.7 0.1 3.2 3 0 0 3 3 3 0 MORN repeat HAD_2 PF13419.6 KOO24513.1 - 1e-18 68.0 0.0 2.5e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO24513.1 - 9.1e-07 28.9 0.1 2.7e-06 27.3 0.1 1.9 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KOO24513.1 - 3e-05 24.4 1.3 3e-05 24.4 1.3 4.2 3 2 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOO24513.1 - 6.7e-05 23.4 0.0 6.7e-05 23.4 0.0 4.3 4 1 0 4 4 4 1 haloacid dehalogenase-like hydrolase LRRFIP PF09738.9 KOO24513.1 - 0.0008 19.0 1.4 0.0016 18.0 1.4 1.4 1 0 0 1 1 1 1 LRRFIP family MT PF12777.7 KOO24513.1 - 0.62 9.0 8.4 0.03 13.4 2.7 1.7 2 0 0 2 2 2 0 Microtubule-binding stalk of dynein motor DUF1400 PF07176.11 KOO24513.1 - 1 9.6 5.0 0.73 10.1 0.0 3.0 3 0 0 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF1400) AAA_13 PF13166.6 KOO24513.1 - 2.3 6.8 3.8 3.6 6.1 3.8 1.3 1 0 0 1 1 1 0 AAA domain IQ PF00612.27 KOO24513.1 - 4.4 7.4 8.1 1.2 9.1 1.5 3.4 3 0 0 3 3 3 0 IQ calmodulin-binding motif C2 PF00168.30 KOO24514.1 - 8.5e-36 122.4 0.0 2e-17 63.4 0.0 2.3 2 0 0 2 2 2 2 C2 domain WW PF00397.26 KOO24514.1 - 2e-24 85.3 7.7 5.7e-12 45.5 1.8 3.3 3 0 0 3 3 3 2 WW domain Cu_amine_oxidN3 PF02728.16 KOO24514.1 - 0.00015 22.1 0.3 0.57 10.6 0.0 2.6 2 0 0 2 2 2 2 Copper amine oxidase, N3 domain MbtH PF03621.13 KOO24514.1 - 0.26 10.8 1.3 21 4.6 0.1 2.4 2 0 0 2 2 2 0 MbtH-like protein RcnB PF11776.8 KOO24514.1 - 1.2 9.2 4.5 17 5.6 0.5 2.5 2 0 0 2 2 2 0 Nickel/cobalt transporter regulator Glyco_transf_29 PF00777.18 KOO24515.1 - 8.7e-25 87.6 0.2 1.6e-22 80.2 0.2 2.4 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) DUF4364 PF14277.6 KOO24515.1 - 0.055 13.2 1.4 0.14 11.9 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Ank_2 PF12796.7 KOO24516.1 - 2.3e-13 50.5 0.4 2.3e-11 44.1 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO24516.1 - 9.5e-10 38.5 0.3 6.9e-05 23.1 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO24516.1 - 3.1e-07 30.8 0.4 0.002 18.6 0.2 3.1 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24516.1 - 4.3e-06 26.7 0.1 0.31 11.7 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KOO24516.1 - 7.4e-06 26.2 1.8 0.033 14.7 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat IHABP4_N PF16174.5 KOO24516.1 - 0.82 10.3 7.8 1.3 9.6 7.8 1.4 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal DUF4464 PF14713.6 KOO24517.1 - 9.6e-98 326.2 1.2 1.1e-97 326.0 1.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4464) AIRS_C PF02769.22 KOO24517.1 - 0.16 12.1 0.0 0.22 11.6 0.0 1.2 1 0 0 1 1 1 0 AIR synthase related protein, C-terminal domain GRP PF07172.11 KOO24518.1 - 0.0051 17.5 7.6 0.0091 16.7 7.6 1.4 1 0 0 1 1 1 1 Glycine rich protein family SAM_1 PF00536.30 KOO24518.1 - 0.029 14.8 0.0 0.087 13.3 0.0 1.7 1 1 1 2 2 2 0 SAM domain (Sterile alpha motif) MAD PF05557.13 KOO24519.1 - 0.15 10.4 31.7 0.22 9.8 31.7 1.3 1 1 0 1 1 1 0 Mitotic checkpoint protein OmpH PF03938.14 KOO24519.1 - 0.26 11.6 33.3 0.82 10.0 10.9 3.1 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) PilJ PF13675.6 KOO24519.1 - 0.3 11.1 7.8 0.096 12.7 0.9 2.6 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term NPR2 PF06218.11 KOO24519.1 - 0.3 9.8 1.9 0.44 9.2 1.9 1.2 1 0 0 1 1 1 0 Nitrogen permease regulator 2 ATG16 PF08614.11 KOO24519.1 - 0.9 9.7 36.4 0.89 9.8 4.4 2.8 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Cob_adeno_trans PF01923.18 KOO24519.1 - 1.3 9.1 10.4 0.69 10.0 6.9 2.3 1 1 2 3 3 3 0 Cobalamin adenosyltransferase Fez1 PF06818.15 KOO24519.1 - 1.3 9.4 32.2 0.17 12.3 21.0 2.2 1 1 1 2 2 2 0 Fez1 Fib_alpha PF08702.10 KOO24519.1 - 1.7 8.8 12.1 0.29 11.3 2.7 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1515 PF07439.11 KOO24519.1 - 2 8.5 11.1 0.31 11.1 5.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) CtIP_N PF10482.9 KOO24519.1 - 3.1 7.8 19.2 0.043 13.9 7.8 3.0 3 1 1 4 4 4 0 Tumour-suppressor protein CtIP N-terminal domain DUF4407 PF14362.6 KOO24519.1 - 3.3 7.0 28.3 3.9 6.7 26.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4404 PF14357.6 KOO24519.1 - 4.1 8.1 25.7 0.43 11.3 0.3 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF4404) DUF16 PF01519.16 KOO24519.1 - 4.8 7.7 24.4 1.2e+02 3.2 7.7 3.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 Exonuc_VII_L PF02601.15 KOO24519.1 - 5.1 6.6 18.0 12 5.4 17.7 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit CC2-LZ PF16516.5 KOO24519.1 - 5.6 7.4 25.8 2.1 8.8 14.1 3.5 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator SOGA PF11365.8 KOO24519.1 - 6.8 7.9 27.1 0.9 10.7 9.2 3.7 1 1 2 3 3 3 0 Protein SOGA Thioesterase PF00975.20 KOO24520.1 - 4.8e-06 26.9 0.6 0.00047 20.4 0.1 2.3 2 0 0 2 2 2 2 Thioesterase domain Abhydrolase_1 PF00561.20 KOO24520.1 - 0.016 14.9 0.1 0.031 13.9 0.1 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Methyltransf_21 PF05050.12 KOO24521.1 - 0.079 13.0 0.0 0.079 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase FkbM domain TFIIA PF03153.13 KOO24522.1 - 7.9 6.4 17.7 3.2 7.7 8.4 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PDZ PF00595.24 KOO24523.1 - 9.2e-24 83.6 1.0 1.4e-06 28.6 0.1 3.3 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KOO24523.1 - 2e-17 62.8 3.1 0.00015 21.5 0.1 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KOO24523.1 - 1.5e-15 57.2 1.7 0.00021 21.5 0.1 3.3 3 0 0 3 3 3 3 PDZ domain BolA PF01722.18 KOO24523.1 - 9e-14 51.5 0.0 2.2e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 BolA-like protein Tricorn_PDZ PF14685.6 KOO24523.1 - 3.3e-05 23.8 2.2 0.61 10.1 0.1 3.9 2 1 0 3 3 3 2 Tricorn protease PDZ domain PDZ_4 PF17816.1 KOO24523.1 - 0.031 14.6 0.1 16 5.9 0.0 3.2 2 1 1 3 3 3 0 PDZ domain Pkinase PF00069.25 KOO24524.1 - 1.1e-67 228.2 0.0 1.5e-67 227.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24524.1 - 5.3e-38 130.8 0.0 7.8e-38 130.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 KOO24524.1 - 4.4e-16 58.7 0.0 1e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_7 PF13499.6 KOO24524.1 - 4.2e-06 27.1 0.0 9.4e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair Kdo PF06293.14 KOO24524.1 - 7.2e-06 25.5 0.0 1.6e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_8 PF13833.6 KOO24524.1 - 7.3e-05 22.5 0.0 0.0038 17.0 0.0 2.9 1 1 2 3 3 3 1 EF-hand domain pair Kinase-like PF14531.6 KOO24524.1 - 0.0041 16.5 0.0 0.0074 15.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO24524.1 - 0.0099 14.7 0.0 0.026 13.3 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KOO24524.1 - 0.012 15.6 0.1 0.05 13.5 0.1 2.0 1 1 0 1 1 1 0 Phosphotransferase enzyme family EF-hand_6 PF13405.6 KOO24524.1 - 0.07 13.1 0.0 0.81 9.8 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain LRR_8 PF13855.6 KOO24525.1 - 4.6e-11 42.3 0.6 2.4e-06 27.2 0.0 2.0 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KOO24525.1 - 6.8e-07 29.5 0.9 6.2e-05 23.3 0.0 2.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) DUF4559 PF15112.6 KOO24525.1 - 0.017 14.8 2.7 0.031 13.9 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Bclx_interact PF08945.10 KOO24525.1 - 0.026 14.3 0.1 0.092 12.5 0.1 1.9 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain LRR_9 PF14580.6 KOO24525.1 - 0.042 13.3 2.5 0.066 12.7 0.2 2.0 2 0 0 2 2 2 0 Leucine-rich repeat Lung_7-TM_R PF06814.13 KOO24527.1 - 0.00068 19.0 17.8 0.00094 18.5 17.8 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 KOO24527.1 - 0.00089 18.7 6.6 0.00089 18.7 6.6 1.6 1 1 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Atg8 PF02991.16 KOO24528.1 - 7e-42 141.8 0.2 1.1e-39 134.7 0.1 2.1 2 0 0 2 2 2 2 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KOO24528.1 - 3.5e-06 27.3 0.0 5.5e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 SHIPPO-rpt PF07004.12 KOO24529.1 - 9.1e-12 45.3 9.9 0.92 10.5 0.2 8.3 8 0 0 8 8 8 7 Sperm-tail PG-rich repeat CRAL_TRIO PF00650.20 KOO24530.1 - 6.4e-19 68.2 0.0 6.9e-19 68.1 0.0 1.0 1 0 0 1 1 1 1 CRAL/TRIO domain EF-hand_5 PF13202.6 KOO24531.1 - 1.1e-07 31.0 2.8 9e-06 25.0 0.1 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO24531.1 - 1.5e-07 30.8 0.2 7.6e-05 22.3 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO24531.1 - 8.3e-06 26.2 0.2 4e-05 24.0 0.2 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO24531.1 - 1.1e-05 24.7 0.0 0.0003 20.1 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO24531.1 - 0.0021 17.9 0.1 0.22 11.4 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain pair Pur_ac_phosph_N PF16656.5 KOO24531.1 - 0.064 13.8 0.3 0.13 12.9 0.3 1.5 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain SPARC_Ca_bdg PF10591.9 KOO24531.1 - 0.13 12.6 0.1 0.68 10.3 0.1 2.1 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region PALP PF00291.25 KOO24532.1 - 2e-19 70.1 1.2 5.5e-19 68.7 1.2 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ABC_tran PF00005.27 KOO24533.1 - 6.5e-42 143.3 0.0 1.5e-24 87.1 0.0 2.3 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 KOO24533.1 - 6.1e-31 107.5 58.4 2.5e-17 63.0 25.6 2.3 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.6 KOO24533.1 - 1.8e-11 44.4 0.4 0.0011 18.8 0.0 3.2 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 KOO24533.1 - 0.00052 20.2 0.9 0.8 10.0 0.0 3.4 3 1 0 3 3 3 2 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 KOO24533.1 - 0.00071 19.5 0.1 0.0017 18.2 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 KOO24533.1 - 0.0008 19.8 0.0 0.0023 18.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO24533.1 - 0.0069 16.7 0.0 0.022 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 KOO24533.1 - 0.0076 15.7 0.0 0.36 10.2 0.0 2.7 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain cobW PF02492.19 KOO24533.1 - 0.02 14.5 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 KOO24533.1 - 0.029 14.9 0.1 0.05 14.1 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO24533.1 - 0.065 13.0 1.2 0.11 12.2 0.2 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.6 KOO24533.1 - 0.12 12.1 0.1 0.3 10.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain Pilus_CpaD PF09476.10 KOO24533.1 - 0.14 11.9 0.0 9.9 5.8 0.0 2.3 2 0 0 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) Rad17 PF03215.15 KOO24533.1 - 0.2 11.6 0.0 0.44 10.4 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain NACHT PF05729.12 KOO24533.1 - 0.37 10.7 2.8 0.2 11.5 0.1 1.9 2 0 0 2 2 2 0 NACHT domain SRP54 PF00448.22 KOO24534.1 - 1.8e-65 220.2 0.8 6.2e-64 215.3 0.8 2.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 KOO24534.1 - 2.1e-26 92.4 0.6 2.1e-26 92.4 0.6 3.5 2 1 1 3 3 2 1 Signal peptide binding domain SRP54_N PF02881.19 KOO24534.1 - 9.4e-15 54.6 2.6 9.4e-15 54.6 2.6 2.0 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 KOO24534.1 - 6.9e-07 29.5 0.1 7e-06 26.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KOO24534.1 - 3.1e-05 23.3 0.0 7.2e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 KOO24534.1 - 0.00092 19.6 0.0 0.0023 18.3 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO24534.1 - 0.0015 18.8 0.1 0.01 16.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain MobB PF03205.14 KOO24534.1 - 0.0023 17.8 0.8 0.14 12.1 0.0 3.1 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.6 KOO24534.1 - 0.0038 17.6 0.1 0.0038 17.6 0.1 2.7 4 0 0 4 4 3 1 AAA domain AAA_30 PF13604.6 KOO24534.1 - 0.0064 16.2 0.2 0.054 13.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain tRNA_lig_kinase PF08303.11 KOO24534.1 - 0.024 14.7 2.0 14 5.7 0.0 3.4 3 0 0 3 3 3 0 tRNA ligase kinase domain MeaB PF03308.16 KOO24534.1 - 0.027 13.5 0.3 0.17 10.9 0.0 2.3 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 KOO24534.1 - 0.027 14.5 0.0 0.23 11.5 0.0 2.3 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain APS_kinase PF01583.20 KOO24534.1 - 0.03 14.2 0.0 0.076 12.9 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.6 KOO24534.1 - 0.039 14.5 0.0 0.15 12.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 KOO24534.1 - 0.04 13.9 0.0 0.091 12.8 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 KOO24534.1 - 0.044 13.3 0.2 0.49 9.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 KOO24534.1 - 0.053 13.2 0.1 0.22 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain TrkA_N PF02254.18 KOO24534.1 - 0.094 13.0 1.3 3.1 8.1 0.1 2.5 2 0 0 2 2 2 0 TrkA-N domain Fis1_TPR_C PF14853.6 KOO24534.1 - 0.12 12.5 0.2 0.12 12.5 0.2 2.0 2 0 0 2 2 1 0 Fis1 C-terminal tetratricopeptide repeat AAA_28 PF13521.6 KOO24534.1 - 0.14 12.4 0.1 0.38 11.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 KOO24534.1 - 0.34 10.2 2.4 0.41 9.9 0.0 2.2 3 0 0 3 3 3 0 6-phosphofructo-2-kinase AAA PF00004.29 KOO24534.1 - 3.3 8.1 6.5 0.66 10.4 0.4 3.1 4 1 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) Bestrophin PF01062.21 KOO24535.1 - 2.4e-27 96.1 1.9 3.8e-27 95.5 1.9 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Sulfatase PF00884.23 KOO24536.1 - 6.2e-50 170.3 0.0 8.6e-50 169.9 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 KOO24536.1 - 1.6e-07 31.2 0.0 0.0056 16.3 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DEAD PF00270.29 KOO24538.1 - 3.5e-15 56.2 0.0 4.8e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO24538.1 - 1.3e-08 35.1 0.0 1.9e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO24538.1 - 0.00044 20.3 0.0 0.00057 19.9 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ribosomal_L2_C PF03947.18 KOO24539.1 - 3.6e-41 140.3 3.4 3.6e-41 140.3 3.4 2.2 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KOO24539.1 - 1.4e-15 57.0 0.4 3.3e-15 55.8 0.4 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain TauD PF02668.16 KOO24540.1 - 4e-31 108.8 0.4 6.5e-30 104.8 0.4 2.2 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-FeII_Oxy PF03171.20 KOO24540.1 - 9.8e-19 67.7 0.0 2e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 KOO24540.1 - 0.18 12.6 0.0 1.2 10.0 0.0 2.1 2 0 0 2 2 2 0 non-haem dioxygenase in morphine synthesis N-terminal Aa_trans PF01490.18 KOO24541.1 - 2.5e-49 168.1 0.0 8.5e-49 166.3 0.0 1.7 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF3357 PF11837.8 KOO24541.1 - 0.28 11.6 2.1 0.58 10.6 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3357) DUF3446 PF11928.8 KOO24541.1 - 3.9 7.9 7.5 0.4 11.0 0.2 2.4 2 1 0 2 2 2 0 Early growth response N-terminal domain SPC12 PF06645.13 KOO24541.1 - 7.2 6.8 7.7 4.5 7.4 0.0 3.2 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) HEAT_EZ PF13513.6 KOO24542.1 - 1.1e-10 41.7 15.4 0.00014 22.3 0.9 5.9 3 2 2 5 5 5 3 HEAT-like repeat HEAT PF02985.22 KOO24542.1 - 1e-08 34.7 9.9 0.00098 19.2 0.0 5.3 5 0 0 5 5 4 2 HEAT repeat Vac14_Fab1_bd PF12755.7 KOO24542.1 - 2.5e-08 34.4 1.4 0.00031 21.3 0.1 3.7 2 1 2 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 KOO24542.1 - 2.1e-07 31.3 5.0 0.012 16.0 0.0 4.6 1 1 3 4 4 4 3 HEAT repeats Cnd1 PF12717.7 KOO24542.1 - 6e-07 29.7 0.0 1.1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 KOO24542.1 - 0.0039 17.1 0.0 2.4 8.1 0.0 2.8 1 1 2 3 3 3 2 UME (NUC010) domain CLASP_N PF12348.8 KOO24542.1 - 0.0042 16.7 0.0 0.1 12.1 0.0 2.1 1 1 2 3 3 3 2 CLASP N terminal Tti2 PF10521.9 KOO24542.1 - 0.0057 16.2 0.0 0.022 14.3 0.0 1.9 1 1 0 1 1 1 1 Tti2 family ParcG PF10274.9 KOO24542.1 - 0.012 15.7 0.0 0.19 11.9 0.0 2.4 1 1 1 3 3 3 0 Parkin co-regulated protein DUF3730 PF12530.8 KOO24542.1 - 0.023 14.3 0.2 0.23 11.0 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3730) Dopey_N PF04118.14 KOO24542.1 - 0.12 11.4 0.1 0.44 9.6 0.0 1.8 1 1 1 2 2 2 0 Dopey, N-terminal MMS19_C PF12460.8 KOO24542.1 - 0.85 8.7 2.3 7.9 5.5 0.6 2.6 2 1 0 2 2 2 0 RNAPII transcription regulator C-terminal Agenet PF05641.12 KOO24544.1 - 8.2e-11 42.2 3.3 0.00071 20.0 0.0 3.7 3 0 0 3 3 3 2 Agenet domain LysM PF01476.20 KOO24544.1 - 0.067 13.3 0.0 12 6.0 0.0 2.5 3 0 0 3 3 3 0 LysM domain Pro_isomerase PF00160.21 KOO24545.1 - 2.3e-39 135.2 0.0 2.6e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Exostosin PF03016.15 KOO24548.1 - 6.5e-40 137.2 4.1 5.3e-37 127.6 4.1 2.6 1 1 0 1 1 1 1 Exostosin family DUF4106 PF13388.6 KOO24548.1 - 4.2 6.5 5.3 6 6.0 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) CD36 PF01130.21 KOO24549.1 - 1.7e-10 40.0 0.0 2.1e-05 23.2 0.0 2.1 2 0 0 2 2 2 2 CD36 family DEAD PF00270.29 KOO24552.1 - 8.5e-33 113.6 0.1 2.2e-32 112.3 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO24552.1 - 5.9e-28 97.4 0.0 7.2e-27 93.9 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO24552.1 - 2.4e-06 27.7 0.1 5.6e-06 26.5 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KOO24552.1 - 0.0007 20.0 0.1 0.0094 16.3 0.1 2.3 2 0 0 2 2 2 1 AAA domain TFIID_30kDa PF03540.13 KOO24552.1 - 0.048 13.6 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit CDC27 PF09507.10 KOO24553.1 - 0.15 11.4 15.2 0.25 10.7 15.2 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SH3-RhoG_link PF16609.5 KOO24553.1 - 1.6 8.4 4.6 2.9 7.6 4.6 1.3 1 0 0 1 1 1 0 SH3-RhoGEF linking unstructured region TPT PF03151.16 KOO24554.1 - 1e-71 241.7 5.0 1.2e-71 241.5 5.0 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO24554.1 - 8.3e-07 29.3 13.6 1.5e-05 25.2 3.7 2.8 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 KOO24554.1 - 0.023 13.9 3.0 0.045 13.0 2.9 1.8 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport UAA PF08449.11 KOO24554.1 - 0.043 13.0 3.8 1.8 7.7 0.4 2.4 2 1 0 2 2 2 0 UAA transporter family DUF5489 PF17592.2 KOO24554.1 - 0.091 13.3 1.9 0.3 11.6 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5489) Ycf66_N PF07444.11 KOO24554.1 - 0.1 12.8 7.1 0.13 12.5 0.4 3.2 4 0 0 4 4 4 0 Ycf66 protein N-terminus DIM PF08194.12 KOO24555.1 - 0.22 11.8 0.3 0.22 11.8 0.3 2.4 3 0 0 3 3 3 0 DIM protein Asp PF00026.23 KOO24556.1 - 2e-13 50.5 0.0 6e-13 48.9 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 KOO24556.1 - 0.0024 18.4 0.1 1.6 9.4 0.0 2.5 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 KOO24556.1 - 0.095 13.3 0.0 15 6.2 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 KOO24556.1 - 0.11 12.2 0.0 0.43 10.4 0.0 1.9 2 1 0 2 2 2 0 Xylanase inhibitor C-terminal GCV_T PF01571.21 KOO24557.1 - 1e-81 274.1 0.0 1.3e-81 273.8 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 KOO24557.1 - 7.3e-21 73.9 0.1 1.7e-20 72.7 0.1 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 KOO24557.1 - 0.00051 20.2 0.0 0.00087 19.5 0.0 1.5 1 0 0 1 1 1 1 Sarcosine oxidase, gamma subunit family PHO4 PF01384.20 KOO24558.1 - 9.3e-91 304.4 23.3 1.1e-90 304.2 23.3 1.0 1 0 0 1 1 1 1 Phosphate transporter family Sde2_N_Ubi PF13019.6 KOO24559.1 - 0.11 12.4 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain IGPS PF00218.21 KOO24560.1 - 2.8e-83 279.0 0.0 7.7e-83 277.5 0.0 1.7 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 KOO24560.1 - 3.2e-46 157.6 0.2 3.6e-41 141.1 0.0 2.2 2 0 0 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase HATPase_c PF02518.26 KOO24561.1 - 3.1e-15 56.7 0.2 6.3e-15 55.7 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOO24561.1 - 6.3e-15 55.3 0.0 1.5e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c_3 PF13589.6 KOO24561.1 - 0.0045 16.8 0.0 0.0083 15.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Arm PF00514.23 KOO24562.1 - 5.2e-227 728.1 191.9 2.5e-09 36.8 0.2 61.7 65 0 0 65 65 64 47 Armadillo/beta-catenin-like repeat EF-hand_6 PF13405.6 KOO24562.1 - 3.4e-34 113.8 4.7 0.00011 21.9 0.1 9.8 10 0 0 10 10 10 6 EF-hand domain EF-hand_1 PF00036.32 KOO24562.1 - 3.9e-30 101.1 3.0 0.0001 21.5 0.1 8.2 9 0 0 9 9 9 6 EF hand Atx10homo_assoc PF09759.9 KOO24562.1 - 2.9e-29 101.0 25.7 0.0003 20.8 0.0 18.2 14 4 5 20 20 20 5 Spinocerebellar ataxia type 10 protein domain EF-hand_7 PF13499.6 KOO24562.1 - 6.5e-29 100.2 0.8 8.5e-08 32.5 0.0 5.2 5 0 0 5 5 5 4 EF-hand domain pair V-ATPase_H_N PF03224.14 KOO24562.1 - 9.4e-27 94.1 9.0 0.00022 20.7 0.0 14.6 5 4 7 13 13 13 5 V-ATPase subunit H EF-hand_5 PF13202.6 KOO24562.1 - 2.1e-21 74.4 14.3 1.2e-05 24.5 0.4 7.4 8 0 0 8 8 8 4 EF hand EF-hand_8 PF13833.6 KOO24562.1 - 1.3e-20 72.9 1.3 2.4e-07 30.5 0.1 6.0 5 1 1 6 6 6 4 EF-hand domain pair Cnd1 PF12717.7 KOO24562.1 - 1.4e-15 57.7 18.1 0.15 12.1 0.1 13.8 10 5 3 14 14 14 4 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.13 KOO24562.1 - 1.7e-15 57.2 30.7 0.023 14.2 0.3 16.9 9 5 8 19 19 19 2 Armadillo-like ABC1 PF03109.16 KOO24562.1 - 1.2e-12 48.1 0.0 3.1e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 ABC1 family DUF5578 PF17741.1 KOO24562.1 - 2.7e-10 40.1 46.2 0.0065 15.9 0.5 14.1 9 4 9 18 18 18 5 Family of unknown function (DUF5578) Adaptin_N PF01602.20 KOO24562.1 - 4.7e-07 28.7 25.7 0.37 9.3 0.0 10.6 9 4 1 11 11 11 3 Adaptin N terminal region KAP PF05804.12 KOO24562.1 - 1.2e-06 27.1 0.0 1.1 7.3 0.0 5.1 4 1 0 5 5 5 2 Kinesin-associated protein (KAP) HEAT_2 PF13646.6 KOO24562.1 - 5e-06 26.8 217.1 0.027 14.9 1.3 29.4 11 10 21 35 35 35 13 HEAT repeats V-ATPase_H_C PF11698.8 KOO24562.1 - 0.00047 20.3 12.1 28 4.8 0.0 8.7 9 0 0 9 9 9 0 V-ATPase subunit H RasGEF_N_2 PF14663.6 KOO24562.1 - 0.0022 18.4 6.5 18 5.8 0.3 9.3 9 1 1 10 10 9 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain MotA_ExbB PF01618.16 KOO24562.1 - 0.15 11.8 11.4 16 5.3 0.1 7.2 6 2 2 8 8 8 0 MotA/TolQ/ExbB proton channel family TAN PF11640.8 KOO24562.1 - 2.3 8.3 7.5 23 5.1 0.2 5.6 6 0 0 6 6 6 0 Telomere-length maintenance and DNA damage repair TIG PF01833.24 KOO24563.1 - 8.3e-48 160.4 28.6 2.5e-05 24.3 0.0 18.0 18 1 0 18 18 18 9 IPT/TIG domain TIG_plexin PF17960.1 KOO24563.1 - 1.3e-14 53.9 0.0 1.2 9.1 0.0 10.8 11 0 0 11 11 11 4 TIG domain fn3 PF00041.21 KOO24563.1 - 1.9e-09 37.8 0.0 4.8e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KOO24563.1 - 0.0013 19.3 0.0 0.0032 18.0 0.0 1.6 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain La PF05383.17 KOO24564.1 - 2.3e-13 50.0 0.0 4.9e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 La domain RRM_3 PF08777.11 KOO24564.1 - 2.2e-08 34.1 0.1 1e-07 31.9 0.0 2.2 2 0 0 2 2 2 1 RNA binding motif PAZ PF02170.22 KOO24564.1 - 0.00058 19.7 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 PAZ domain RRM_1 PF00076.22 KOO24564.1 - 0.015 15.1 0.0 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_1 PF00036.32 KOO24565.1 - 5.1e-07 28.8 0.9 0.12 12.0 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO24565.1 - 7.4e-06 25.5 1.4 0.57 10.3 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KOO24565.1 - 0.00032 20.0 3.1 1.8 8.2 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO24565.1 - 0.00046 20.0 0.1 0.17 11.7 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO24565.1 - 0.0011 19.3 1.4 0.022 15.2 1.4 2.5 1 1 0 1 1 1 1 EF-hand domain pair Asp-B-Hydro_N PF05279.11 KOO24565.1 - 0.0036 17.4 0.0 0.0076 16.3 0.0 1.6 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region HisKA_3 PF07730.13 KOO24565.1 - 0.1 13.1 0.8 0.1 13.1 0.8 3.0 3 0 0 3 3 3 0 Histidine kinase HEAT PF02985.22 KOO24567.1 - 1.2e-26 90.4 27.2 0.018 15.3 0.1 11.5 10 1 1 11 11 11 8 HEAT repeat HEAT_2 PF13646.6 KOO24567.1 - 1.5e-22 79.8 31.6 3.5e-06 27.3 2.8 7.9 2 1 5 8 8 8 6 HEAT repeats HEAT_EZ PF13513.6 KOO24567.1 - 6.1e-20 71.3 32.8 0.0019 18.7 0.2 8.8 6 2 2 8 8 8 8 HEAT-like repeat Cnd1 PF12717.7 KOO24567.1 - 1.1e-09 38.5 10.0 0.0025 17.9 0.0 6.3 4 3 4 8 8 8 3 non-SMC mitotic condensation complex subunit 1 ART PF01129.18 KOO24567.1 - 3.3e-08 33.1 0.0 5.3e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Adaptin_N PF01602.20 KOO24567.1 - 1.1e-06 27.5 1.9 0.00025 19.8 0.9 3.5 2 2 0 2 2 2 1 Adaptin N terminal region ADPrib_exo_Tox PF03496.14 KOO24567.1 - 0.00011 21.6 0.0 0.00019 20.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Vac14_Fab1_bd PF12755.7 KOO24567.1 - 0.0007 20.2 1.1 8.5 7.0 0.1 5.6 4 3 2 6 6 6 1 Vacuolar 14 Fab1-binding region Dimer_Tnp_hAT PF05699.14 KOO24567.1 - 0.027 14.2 0.0 0.077 12.8 0.0 1.7 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region Arm PF00514.23 KOO24567.1 - 0.14 12.3 13.9 5.6 7.2 0.1 6.9 8 1 1 9 9 9 0 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 KOO24567.1 - 0.57 9.7 4.7 4.4 6.8 0.1 4.1 4 2 2 6 6 6 0 CLASP N terminal HEAT_PBS PF03130.16 KOO24567.1 - 1.3 9.9 21.8 8.4 7.4 0.0 8.3 8 2 1 9 9 8 0 PBS lyase HEAT-like repeat DUF4042 PF13251.6 KOO24567.1 - 6.7 6.4 11.9 7 6.3 0.0 5.4 5 3 0 6 6 6 0 Domain of unknown function (DUF4042) Metal_resist PF13801.6 KOO24569.1 - 0.089 13.0 4.2 0.17 12.0 4.2 1.4 1 0 0 1 1 1 0 Heavy-metal resistance Smg8_Smg9 PF10220.9 KOO24569.1 - 2.3 6.4 9.1 2.4 6.4 9.1 1.1 1 0 0 1 1 1 0 Smg8_Smg9 TFIIF_alpha PF05793.12 KOO24569.1 - 3.1 6.3 33.5 3.6 6.1 33.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 KOO24569.1 - 3.2 5.9 21.6 3.8 5.7 21.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 KOO24569.1 - 4.5 5.9 14.9 5.4 5.7 14.9 1.2 1 0 0 1 1 1 0 Presenilin Prenyltransf PF01255.19 KOO24571.1 - 5e-41 140.7 0.0 7.9e-41 140.0 0.0 1.3 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Dynein_light PF01221.18 KOO24571.1 - 9.1e-30 102.8 3.5 1.4e-29 102.3 2.6 1.8 2 0 0 2 2 2 1 Dynein light chain type 1 DUF4225 PF13988.6 KOO24572.1 - 0.026 14.1 0.9 0.041 13.4 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) Ion_trans PF00520.31 KOO24573.1 - 1.5e-23 83.3 7.2 3.4e-22 78.9 7.2 2.1 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO24573.1 - 5.4e-11 42.3 3.3 1.8e-10 40.6 3.3 1.8 1 0 0 1 1 1 1 Ion channel cNMP_binding PF00027.29 KOO24573.1 - 2.2e-09 37.3 0.1 2.4e-07 30.7 0.1 3.4 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain Acyl-CoA_dh_C PF12806.7 KOO24573.1 - 0.036 14.2 1.9 0.19 11.9 0.1 2.7 2 1 1 3 3 3 0 Acetyl-CoA dehydrogenase C-terminal like Tsc35 PF15079.6 KOO24573.1 - 0.065 12.8 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 Testis-specific protein 35 WRW PF10206.9 KOO24573.1 - 4.3 7.8 4.7 2.6 8.5 1.2 2.4 2 1 0 2 2 2 0 Mitochondrial F1F0-ATP synthase, subunit f CHAD PF05235.14 KOO24574.1 - 0.015 15.3 0.0 0.018 15.0 0.0 1.1 1 0 0 1 1 1 0 CHAD domain Pam16 PF03656.13 KOO24575.1 - 4.7e-10 39.6 0.0 6e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 KOO24575.1 - 0.084 13.0 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 DnaJ domain DUF155 PF02582.14 KOO24576.1 - 3.3e-42 144.6 0.1 4.6e-42 144.1 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 5_nucleotid PF05761.14 KOO24577.1 - 5.3e-107 358.6 0.0 5.9e-107 358.4 0.0 1.0 1 0 0 1 1 1 1 5' nucleotidase family MDH PF02315.16 KOO24577.1 - 0.089 12.9 0.1 0.24 11.5 0.1 1.7 1 1 0 1 1 1 0 Methanol dehydrogenase beta subunit SH3_2 PF07653.17 KOO24578.1 - 1.3e-11 44.0 0.2 9.4e-11 41.2 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 KOO24578.1 - 2.6e-11 43.2 0.0 6.1e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KOO24578.1 - 3.8e-09 36.0 0.0 7.5e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain FAD_binding_3 PF01494.19 KOO24578.1 - 0.00036 19.9 0.1 0.0007 18.9 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 KOO24578.1 - 0.00086 18.6 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOO24578.1 - 0.00093 18.5 0.1 0.0018 17.6 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO24578.1 - 0.012 14.4 0.0 0.019 13.7 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 KOO24578.1 - 0.012 16.1 0.2 0.023 15.2 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO24578.1 - 0.012 14.7 0.1 0.031 13.4 0.1 1.7 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 KOO24578.1 - 0.04 13.5 0.1 0.082 12.5 0.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOO24578.1 - 0.046 14.0 0.0 0.18 12.0 0.0 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 KOO24578.1 - 0.12 12.8 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding IQ PF00612.27 KOO24579.1 - 0.00094 18.8 1.4 0.0027 17.4 1.4 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif KIAA1430 PF13879.6 KOO24580.1 - 9.8e-15 55.2 0.0 1.7e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 KIAA1430 homologue Kelch_5 PF13854.6 KOO24581.1 - 7.7e-18 64.1 0.3 1.2e-05 25.1 0.0 4.3 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 KOO24581.1 - 1.7e-17 63.1 0.1 5.3e-05 23.2 0.0 3.7 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KOO24581.1 - 1.6e-15 56.9 0.4 4.1e-05 23.7 0.1 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO24581.1 - 6.2e-14 51.7 0.1 8e-05 22.8 0.0 3.8 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KOO24581.1 - 5e-13 48.4 0.0 0.0029 17.2 0.0 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KOO24581.1 - 1.7e-10 40.4 0.2 0.041 13.9 0.0 3.8 4 0 0 4 4 4 3 Kelch motif PsbQ PF05757.11 KOO24582.1 - 0.024 14.4 3.0 0.82 9.4 0.1 2.3 2 0 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) EF-hand_1 PF00036.32 KOO24583.1 - 3.8e-43 141.8 27.9 2.2e-05 23.7 0.1 8.6 8 0 0 8 8 8 8 EF hand EF-hand_6 PF13405.6 KOO24583.1 - 8.6e-41 134.4 25.2 2.4e-05 23.9 0.0 8.7 8 0 0 8 8 8 8 EF-hand domain EF-hand_7 PF13499.6 KOO24583.1 - 1.5e-36 124.6 23.3 4.5e-09 36.6 3.3 6.0 5 1 2 7 7 7 7 EF-hand domain pair EF-hand_5 PF13202.6 KOO24583.1 - 1.4e-29 100.3 27.6 0.00011 21.5 0.0 8.4 8 0 0 8 8 8 7 EF hand EF-hand_8 PF13833.6 KOO24583.1 - 4.8e-24 84.0 24.8 3e-05 23.8 2.1 8.0 6 2 2 8 8 8 7 EF-hand domain pair EF-hand_4 PF12763.7 KOO24583.1 - 2.6e-05 24.1 15.4 0.046 13.7 0.5 4.6 5 2 1 6 6 6 3 Cytoskeletal-regulatory complex EF hand IQ PF00612.27 KOO24583.1 - 0.00052 19.6 0.1 0.0016 18.1 0.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif Caleosin PF05042.13 KOO24583.1 - 0.016 15.1 1.4 10 6.0 0.0 4.5 4 2 1 5 5 5 0 Caleosin related protein Milton PF12448.8 KOO24583.1 - 0.021 15.0 0.4 0.045 13.9 0.4 1.6 1 0 0 1 1 1 0 Kinesin associated protein DUF357 PF04010.13 KOO24583.1 - 0.027 14.6 0.0 0.41 10.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF357) EF-hand_9 PF14658.6 KOO24583.1 - 0.038 14.3 1.8 48 4.4 0.0 4.5 5 0 0 5 5 4 0 EF-hand domain Methyltransf_24 PF13578.6 KOO24583.1 - 0.048 14.7 0.9 0.23 12.5 0.9 2.3 1 0 0 1 1 1 0 Methyltransferase domain SPARC_Ca_bdg PF10591.9 KOO24583.1 - 1.7 9.0 13.6 12 6.2 1.1 5.0 5 1 1 7 7 7 0 Secreted protein acidic and rich in cysteine Ca binding region PrmC_N PF17827.1 KOO24584.1 - 0.021 15.4 0.1 0.037 14.6 0.1 1.4 1 0 0 1 1 1 0 PrmC N-terminal domain Amino_oxidase PF01593.24 KOO24585.1 - 1e-31 110.7 0.5 7.4e-30 104.6 0.2 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Tudor-knot PF11717.8 KOO24585.1 - 0.053 13.4 0.2 0.14 12.1 0.2 1.7 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Tudor_4 PF18358.1 KOO24585.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain DENN PF02141.21 KOO24587.1 - 7.3e-14 52.1 0.0 1.1e-13 51.6 0.0 1.2 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 KOO24587.1 - 0.034 14.9 0.0 0.063 14.0 0.0 1.4 1 0 0 1 1 1 0 uDENN domain RPN13_C PF16550.5 KOO24588.1 - 0.011 15.9 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 UCH-binding domain DUF3443 PF11925.8 KOO24588.1 - 0.12 11.1 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3443) RPN7 PF10602.9 KOO24590.1 - 9.6e-54 181.7 0.7 1.5e-53 181.1 0.7 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 KOO24590.1 - 4.8e-15 56.0 0.6 1.5e-14 54.4 0.1 2.0 2 1 0 2 2 2 1 PCI domain TPR_2 PF07719.17 KOO24590.1 - 0.0039 17.2 1.6 0.1 12.8 0.2 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO24590.1 - 0.026 14.4 0.9 0.058 13.2 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.6 KOO24590.1 - 0.055 12.9 1.1 0.14 11.6 1.2 1.6 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 KOO24590.1 - 0.066 12.9 0.6 0.14 11.9 0.1 1.8 2 0 0 2 2 2 0 TPR repeat UPF0061 PF02696.14 KOO24591.1 - 9.4e-93 311.5 0.0 1.2e-92 311.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family DUF5610 PF18433.1 KOO24591.1 - 0.061 13.8 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5610) Phage_Cox PF10743.9 KOO24591.1 - 0.13 12.3 0.2 0.36 10.9 0.2 1.7 1 0 0 1 1 1 0 Regulatory phage protein cox GDA1_CD39 PF01150.17 KOO24592.1 - 5.7e-44 150.4 0.0 7.2e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Pelovaterin PF17859.1 KOO24592.1 - 1.7 9.0 5.5 5.2 7.4 3.7 2.3 2 0 0 2 2 2 0 Pelovaterin DUF563 PF04577.14 KOO24594.1 - 3.3e-15 56.8 0.0 9.8e-15 55.2 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Morc6_S5 PF17942.1 KOO24594.1 - 1.7e-09 37.9 0.0 1.7e-05 24.9 0.0 2.4 2 0 0 2 2 2 2 Morc6 ribosomal protein S5 domain 2-like HATPase_c_3 PF13589.6 KOO24594.1 - 8.4e-07 28.9 0.0 4e-06 26.7 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LRR_4 PF12799.7 KOO24594.1 - 8.7e-05 22.8 0.0 6.4 7.4 0.1 4.2 2 1 3 5 5 5 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO24594.1 - 0.0002 21.1 3.0 2.1 8.6 0.2 5.3 6 0 0 6 6 6 1 Leucine Rich repeat Mto2_bdg PF12808.7 KOO24596.1 - 0.0099 16.2 0.8 29 5.1 0.0 4.0 4 0 0 4 4 4 2 Micro-tubular organiser Mto1 C-term Mto2-binding region Glyco_transf_8 PF01501.20 KOO24597.1 - 0.11 12.1 0.0 0.13 11.8 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferase family 8 Orexin_rec2 PF03827.13 KOO24598.1 - 0.13 12.3 0.8 0.2 11.7 0.2 1.6 1 1 1 2 2 2 0 Orexin receptor type 2 adh_short PF00106.25 KOO24599.1 - 6.3e-32 110.6 0.0 7.7e-26 90.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO24599.1 - 2.4e-23 82.9 0.0 1.2e-15 57.7 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO24599.1 - 6.3e-06 26.2 0.1 1e-05 25.5 0.0 1.4 1 1 0 1 1 1 1 KR domain Lactamase_B PF00753.27 KOO24600.1 - 4.9e-08 33.2 0.0 5e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOO24600.1 - 8e-07 28.8 0.0 9.5e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 KOO24600.1 - 1.6e-05 24.4 0.0 2.3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 tRNase Z endonuclease Ras PF00071.22 KOO24602.1 - 1.9e-61 206.4 0.3 2.2e-61 206.2 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO24602.1 - 1.9e-32 112.0 0.3 2.7e-32 111.5 0.3 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO24602.1 - 1.4e-15 57.2 0.1 1.7e-15 56.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOO24602.1 - 7.3e-06 25.5 0.1 1e-05 25.0 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO24602.1 - 3.1e-05 24.0 0.1 6.8e-05 22.9 0.1 1.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOO24602.1 - 9.2e-05 22.1 0.1 0.00017 21.2 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KOO24602.1 - 0.0015 19.0 0.0 0.0025 18.2 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 KOO24602.1 - 0.0082 15.9 0.0 0.088 12.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO24602.1 - 0.013 15.4 0.0 0.28 11.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_25 PF13481.6 KOO24602.1 - 0.016 14.8 0.1 4.7 6.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 KOO24602.1 - 0.026 14.5 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 KOO24602.1 - 0.032 13.6 0.0 0.055 12.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_7 PF12775.7 KOO24602.1 - 0.032 13.7 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region MCM PF00493.23 KOO24602.1 - 0.037 13.1 0.0 0.096 11.8 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain AAA_22 PF13401.6 KOO24602.1 - 0.068 13.4 0.0 0.27 11.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 KOO24602.1 - 0.11 12.0 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Sod_Cu PF00080.20 KOO24604.1 - 4.1e-45 153.4 1.2 5e-45 153.2 1.2 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Pkinase PF00069.25 KOO24605.1 - 5.1e-63 212.9 0.0 6.2e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24605.1 - 1.3e-27 96.7 0.0 2.1e-27 96.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO24605.1 - 0.012 14.6 0.0 0.02 13.8 0.0 1.3 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 KOO24605.1 - 0.03 13.7 0.1 0.066 12.6 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO24605.1 - 0.035 13.4 0.0 0.1 11.9 0.0 1.8 3 0 0 3 3 3 0 Kinase-like AOX PF01786.17 KOO24607.1 - 9.3e-37 126.7 0.0 1.2e-36 126.3 0.0 1.1 1 0 0 1 1 1 1 Alternative oxidase Dynamin_M PF01031.20 KOO24608.1 - 4.3e-72 242.7 0.0 7e-72 242.0 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 KOO24608.1 - 3.3e-50 170.4 0.0 5.2e-50 169.8 0.0 1.3 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 KOO24608.1 - 5.1e-26 90.7 1.1 8.5e-26 89.9 1.1 1.4 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KOO24608.1 - 0.00058 19.9 0.0 0.0027 17.8 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 KOO24608.1 - 0.23 11.7 0.0 0.52 10.5 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Nucleotid_trans PF03407.16 KOO24610.1 - 3.7e-18 66.3 0.0 5.7e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Lipase_GDSL_2 PF13472.6 KOO24611.1 - 0.00017 22.0 0.2 0.0004 20.8 0.2 1.7 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Sugar_tr PF00083.24 KOO24612.1 - 3.4e-16 59.2 8.2 3.4e-16 59.2 8.2 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO24612.1 - 1.1e-14 54.2 20.4 1.4e-14 53.8 20.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1681 PF07933.14 KOO24614.1 - 4.4e-47 159.5 0.0 5.6e-47 159.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) AAA_lid_6 PF17866.1 KOO24615.1 - 9e-06 25.8 1.9 1.9e-05 24.7 1.9 1.5 1 0 0 1 1 1 1 AAA lid domain Pkinase PF00069.25 KOO24616.1 - 2.2e-61 207.5 0.0 3e-61 207.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24616.1 - 9.6e-34 116.8 0.0 1.4e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 KOO24616.1 - 3.2e-33 110.8 6.4 2.3e-08 33.0 0.2 5.1 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 KOO24616.1 - 2.9e-29 98.4 1.2 3.2e-07 29.8 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO24616.1 - 1.6e-28 99.0 0.0 3.8e-15 56.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO24616.1 - 4.1e-23 81.0 1.5 5e-11 42.3 0.0 4.3 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO24616.1 - 3e-21 73.9 7.3 1.2e-06 27.7 0.1 4.3 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.9 KOO24616.1 - 5.2e-08 33.2 0.0 0.0077 16.5 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO24616.1 - 1.3e-07 31.5 0.1 0.078 12.9 0.0 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Pkinase_fungal PF17667.1 KOO24616.1 - 2.4e-07 29.9 0.0 3.6e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase EF-hand_9 PF14658.6 KOO24616.1 - 0.00014 22.1 0.0 0.24 11.8 0.0 3.2 2 1 0 2 2 2 2 EF-hand domain Kdo PF06293.14 KOO24616.1 - 0.00043 19.7 0.0 0.00071 19.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO24616.1 - 0.00066 19.1 0.0 0.00099 18.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO24616.1 - 0.029 14.3 0.1 0.069 13.1 0.1 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family p25-alpha PF05517.12 KOO24616.1 - 0.031 14.5 0.0 0.93 9.6 0.1 2.3 2 0 0 2 2 2 0 p25-alpha TerB PF05099.13 KOO24616.1 - 0.16 11.9 0.4 16 5.5 0.0 2.8 2 1 1 3 3 3 0 Tellurite resistance protein TerB Arm PF00514.23 KOO24618.1 - 9.4e-09 35.0 20.8 0.054 13.5 0.3 7.3 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO24618.1 - 0.0031 18.0 1.4 0.0031 18.0 1.4 4.2 4 2 1 5 5 5 1 HEAT-like repeat Arm_2 PF04826.13 KOO24618.1 - 0.022 14.2 0.0 3.5 7.0 0.0 2.8 2 2 1 3 3 3 0 Armadillo-like PUL PF08324.11 KOO24618.1 - 0.16 11.2 5.3 1.6 7.9 0.3 3.1 2 1 0 3 3 3 0 PUL domain Nup54 PF13874.6 KOO24618.1 - 0.2 11.7 0.6 0.42 10.7 0.6 1.5 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 SecA_DEAD PF07517.14 KOO24619.1 - 1.6e-08 34.2 0.3 6.8e-08 32.1 0.0 2.2 2 0 0 2 2 2 1 SecA DEAD-like domain MMR_HSR1 PF01926.23 KOO24619.1 - 0.00027 21.0 0.1 0.00096 19.2 0.1 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Helicase_C PF00271.31 KOO24619.1 - 0.00031 21.0 0.0 0.00087 19.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RsgA_GTPase PF03193.16 KOO24619.1 - 0.0054 16.6 0.1 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 RsgA GTPase Septin PF00735.18 KOO24619.1 - 0.023 14.0 0.0 0.045 13.0 0.0 1.3 1 0 0 1 1 1 0 Septin ABC_tran PF00005.27 KOO24619.1 - 0.024 15.1 0.0 0.12 12.9 0.0 2.2 1 0 0 1 1 1 0 ABC transporter ResIII PF04851.15 KOO24619.1 - 0.12 12.4 0.1 1.2 9.1 0.0 2.8 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit PAE PF03283.13 KOO24620.1 - 7.7e-37 127.2 0.0 1e-36 126.8 0.0 1.2 1 0 0 1 1 1 1 Pectinacetylesterase Ion_trans PF00520.31 KOO24621.1 - 3.3e-39 134.6 2.3 4.2e-39 134.2 2.3 1.0 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO24621.1 - 2.3e-13 49.9 3.1 2.3e-13 49.9 3.1 2.0 2 1 1 3 3 3 1 Ion channel Pol_alpha_B_N PF08418.10 KOO24621.1 - 0.0032 17.5 2.0 0.0045 17.0 2.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal IRK PF01007.20 KOO24621.1 - 0.012 15.4 0.7 0.023 14.5 0.7 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain Lig_chan PF00060.26 KOO24621.1 - 0.038 13.8 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Ligand-gated ion channel OAD_gamma PF04277.13 KOO24621.1 - 0.046 14.3 9.0 0.056 14.0 0.0 3.3 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF4605 PF15378.6 KOO24621.1 - 0.11 12.3 2.3 0.25 11.2 2.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) DUF2614 PF11023.8 KOO24621.1 - 0.54 10.4 5.6 0.18 11.9 2.3 1.8 2 0 0 2 2 2 0 Zinc-ribbon containing domain CDC37_N PF03234.14 KOO24621.1 - 0.94 10.4 4.2 4.7 8.1 0.5 2.1 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding DnaJ PF00226.31 KOO24622.1 - 1.1e-19 70.2 0.1 1.8e-19 69.6 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain PDZ_6 PF17820.1 KOO24622.1 - 1.4e-07 31.2 0.0 3.3e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain fn3 PF00041.21 KOO24622.1 - 2.1e-06 28.0 0.0 6.7e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 Fibronectin type III domain PDZ PF00595.24 KOO24622.1 - 1.2e-05 25.6 0.0 2.5e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO24622.1 - 0.0047 17.2 0.0 0.0099 16.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PhoD_N PF16655.5 KOO24622.1 - 0.1 13.2 0.0 7.3 7.2 0.0 2.4 2 0 0 2 2 2 0 PhoD-like phosphatase, N-terminal domain TPR_8 PF13181.6 KOO24623.1 - 1.4e-05 24.9 1.0 0.21 11.9 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat START PF01852.19 KOO24623.1 - 6.7e-05 22.4 0.1 0.00015 21.2 0.1 1.6 1 0 0 1 1 1 1 START domain TPR_1 PF00515.28 KOO24623.1 - 0.00088 19.0 4.5 0.072 12.9 0.3 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO24623.1 - 0.0019 18.2 6.5 0.03 14.4 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO24623.1 - 0.0022 18.7 2.1 0.69 10.9 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO24623.1 - 0.0051 16.7 0.3 3.4 7.9 0.1 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO24623.1 - 0.05 13.3 0.1 16 5.3 0.1 2.6 2 0 0 2 2 2 0 TPR repeat LrgB PF04172.16 KOO24624.1 - 1.9e-36 125.6 16.1 1.9e-36 125.6 16.1 1.8 2 0 0 2 2 2 1 LrgB-like family LrgA PF03788.14 KOO24624.1 - 0.0042 17.0 17.1 0.035 14.1 3.5 3.5 2 1 1 3 3 3 2 LrgA family MgsA_C PF12002.8 KOO24624.1 - 0.82 9.6 2.5 11 5.9 0.1 2.3 1 1 1 2 2 2 0 MgsA AAA+ ATPase C terminal EF-hand_1 PF00036.32 KOO24625.1 - 1.8e-09 36.5 0.0 0.0071 15.8 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KOO24625.1 - 1.5e-08 33.9 0.0 0.0064 16.3 0.0 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KOO24625.1 - 2.6e-07 29.8 0.1 0.04 13.4 0.0 3.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO24625.1 - 3e-07 30.8 0.1 0.12 12.9 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO24625.1 - 1.5e-05 24.8 0.1 0.085 12.7 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair SHOCT PF09851.9 KOO24625.1 - 1.6 8.5 17.1 5.6 6.8 0.8 4.8 5 0 0 5 5 5 0 Short C-terminal domain DehI PF10778.9 KOO24625.1 - 7.7 6.7 9.9 84 3.3 9.9 2.5 1 1 0 1 1 1 0 Halocarboxylic acid dehydrogenase DehI EF-hand_6 PF13405.6 KOO24626.1 - 3.2e-14 51.6 0.3 3.5e-06 26.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO24626.1 - 8.1e-13 46.9 0.4 5.3e-05 22.5 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO24626.1 - 1.8e-10 41.1 0.2 1.8e-10 41.1 0.2 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO24626.1 - 1.2e-08 34.6 0.1 7.1e-07 29.0 0.1 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO24626.1 - 1e-07 31.1 0.3 0.0024 17.3 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_14 PF17959.1 KOO24626.1 - 0.0062 16.9 0.1 0.0062 16.9 0.1 3.2 3 1 0 3 3 3 1 EF-hand domain PIG-L PF02585.17 KOO24626.1 - 0.072 13.7 0.0 0.072 13.7 0.0 3.4 1 1 1 2 2 1 0 GlcNAc-PI de-N-acetylase GATase_5 PF13507.6 KOO24626.1 - 0.16 11.0 3.3 14 4.7 3.3 2.2 1 1 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Exonuc_VII_L PF02601.15 KOO24626.1 - 0.19 11.3 17.2 0.43 10.1 17.2 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 KOO24626.1 - 0.85 9.7 14.9 0.55 10.3 3.0 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Fez1 PF06818.15 KOO24626.1 - 2 8.8 37.1 0.062 13.7 26.3 2.6 1 1 2 3 3 3 0 Fez1 Rootletin PF15035.6 KOO24626.1 - 4.6 7.2 31.7 5.7e+02 0.4 31.7 2.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF3135 PF11333.8 KOO24626.1 - 5.5 7.3 9.9 0.27 11.5 0.3 3.0 2 1 2 4 4 4 0 Protein of unknown function (DUF3135) Ribosomal_S21e PF01249.18 KOO24627.1 - 1.5e-35 121.2 0.0 1.8e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S21e Methyltransf_31 PF13847.6 KOO24628.1 - 1.4e-23 83.3 0.0 2.1e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO24628.1 - 2.1e-23 82.8 0.0 4.2e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO24628.1 - 2.2e-23 82.8 0.0 4e-23 81.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO24628.1 - 3.8e-21 75.6 0.0 6e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO24628.1 - 8e-17 61.8 0.0 1.5e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO24628.1 - 2.4e-13 50.0 0.0 3.2e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 KOO24628.1 - 3.1e-12 46.4 0.0 4.9e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 KOO24628.1 - 3.2e-08 32.6 0.0 4.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_4 PF02390.17 KOO24628.1 - 1.2e-06 28.1 0.0 0.00037 20.0 0.0 2.4 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_PK PF05891.12 KOO24628.1 - 1.3e-05 24.8 0.0 2.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase MTS PF05175.14 KOO24628.1 - 2.8e-05 23.7 0.0 5.6e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 KOO24628.1 - 7.9e-05 22.5 0.0 0.00012 21.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NAS PF03059.16 KOO24628.1 - 0.00013 21.5 0.0 0.00017 21.1 0.0 1.1 1 0 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_8 PF05148.15 KOO24628.1 - 0.00017 21.5 0.0 0.00046 20.1 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase DREV PF05219.12 KOO24628.1 - 0.0004 19.6 0.0 0.00091 18.4 0.0 1.5 2 0 0 2 2 2 1 DREV methyltransferase Methyltransf_32 PF13679.6 KOO24628.1 - 0.0013 18.7 0.0 0.002 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 KOO24628.1 - 0.0024 17.5 0.0 0.0038 16.8 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW NodS PF05401.11 KOO24628.1 - 0.0086 15.7 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) ADH_zinc_N PF00107.26 KOO24628.1 - 0.012 15.6 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase TehB PF03848.14 KOO24628.1 - 0.017 14.6 0.0 0.039 13.4 0.0 1.7 2 1 0 2 2 1 0 Tellurite resistance protein TehB Methyltransf_2 PF00891.18 KOO24628.1 - 0.02 14.2 0.0 0.053 12.8 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase domain Methyltransf_9 PF08003.11 KOO24628.1 - 0.023 13.6 0.0 0.03 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) FtsJ PF01728.19 KOO24628.1 - 0.024 14.8 0.0 0.079 13.1 0.0 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase DUF5305 PF17231.2 KOO24628.1 - 0.086 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF938 PF06080.12 KOO24628.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Shikimate_DH PF01488.20 KOO24628.1 - 0.18 11.9 0.0 0.28 11.3 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Methyltransf_5 PF01795.19 KOO24628.1 - 0.22 11.0 0.0 6.8 6.1 0.0 2.1 2 0 0 2 2 2 0 MraW methylase family TPR_2 PF07719.17 KOO24629.1 - 0.0032 17.5 0.5 0.2 11.8 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO24629.1 - 0.02 14.8 2.4 0.11 12.4 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO24629.1 - 0.02 15.1 0.1 0.75 10.2 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat SAP130_C PF16014.5 KOO24629.1 - 1.8 7.5 8.8 2.7 7.0 0.1 2.2 1 1 1 2 2 2 0 Histone deacetylase complex subunit SAP130 C-terminus Sugar_tr PF00083.24 KOO24632.1 - 0.0029 16.6 1.4 0.0036 16.2 0.9 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO24632.1 - 0.23 10.4 14.6 0.07 12.0 10.1 1.9 1 1 1 2 2 2 0 Major Facilitator Superfamily Transport_MerF PF11431.8 KOO24632.1 - 1.2 9.1 11.6 0.78 9.7 0.3 3.2 3 0 0 3 3 3 0 Membrane transport protein MerF Mntp PF02659.15 KOO24634.1 - 0.015 15.1 20.3 0.15 11.8 6.6 3.4 2 1 1 3 3 3 0 Putative manganese efflux pump GCIP PF13324.6 KOO24635.1 - 4.3e-08 33.1 2.1 5.7e-08 32.7 2.1 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Mu-like_Pro PF10123.9 KOO24635.1 - 0.0082 15.7 5.7 0.012 15.2 5.7 1.3 1 0 0 1 1 1 1 Mu-like prophage I protein NADH_4Fe-4S PF10589.9 KOO24635.1 - 0.034 14.2 0.1 0.1 12.7 0.1 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region I_LWEQ PF01608.17 KOO24635.1 - 0.048 13.9 5.9 1.4 9.1 0.7 2.9 2 1 1 3 3 3 0 I/LWEQ domain MbeB_N PF04837.12 KOO24635.1 - 0.064 13.6 0.2 0.2 12.0 0.2 1.9 1 0 0 1 1 1 0 MbeB-like, N-term conserved region MotA_ExbB PF01618.16 KOO24635.1 - 0.069 12.9 0.2 0.18 11.6 0.2 1.8 1 1 0 1 1 1 0 MotA/TolQ/ExbB proton channel family DUF842 PF05811.13 KOO24635.1 - 0.12 12.1 0.4 0.53 10.0 0.4 2.0 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) DnaJ PF00226.31 KOO24636.1 - 1.6e-15 56.9 0.1 3.8e-15 55.8 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain ADH_zinc_N PF00107.26 KOO24636.1 - 1.7e-12 47.4 0.0 4.1e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SAM_1 PF00536.30 KOO24636.1 - 2.3e-05 24.8 0.1 0.00022 21.6 0.1 2.6 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO24636.1 - 0.003 17.6 0.2 0.029 14.5 0.2 2.7 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) Ribosomal_L15e PF00827.17 KOO24637.1 - 1.2e-83 279.6 9.9 1.4e-83 279.4 9.9 1.0 1 0 0 1 1 1 1 Ribosomal L15 LRR_6 PF13516.6 KOO24638.1 - 6.5e-08 32.0 0.9 1.7e-05 24.5 0.2 3.1 2 0 0 2 2 2 2 Leucine Rich repeat Metallophos PF00149.28 KOO24640.1 - 1.2e-06 29.2 0.0 2.7e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO24640.1 - 3e-05 24.3 0.0 5.8e-05 23.3 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PAE PF03283.13 KOO24642.1 - 3.4e-34 118.5 0.1 1.1e-30 107.0 0.0 2.0 1 1 1 2 2 2 2 Pectinacetylesterase Aldo_ket_red PF00248.21 KOO24643.1 - 3.1e-52 177.6 0.0 4.1e-52 177.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Adaptin_N PF01602.20 KOO24645.1 - 3.4e-95 319.6 8.7 4.8e-95 319.1 8.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 KOO24645.1 - 1.4e-55 186.8 0.0 3e-55 185.6 0.0 1.6 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 KOO24645.1 - 2.6e-49 166.7 0.1 5.6e-49 165.7 0.1 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Cnd1 PF12717.7 KOO24645.1 - 7e-08 32.7 5.9 8.4e-07 29.2 0.7 2.5 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 DUF5071 PF16804.5 KOO24645.1 - 0.055 13.7 0.3 20 5.4 0.4 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF5071) HEAT PF02985.22 KOO24645.1 - 0.095 13.0 2.9 3.1 8.3 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat DUF5578 PF17741.1 KOO24645.1 - 0.67 9.3 5.8 1.2 8.5 3.0 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5578) ParcG PF10274.9 KOO24645.1 - 0.91 9.6 5.4 8.7 6.4 0.7 3.6 3 1 1 4 4 4 0 Parkin co-regulated protein Wzy_C_2 PF11846.8 KOO24647.1 - 0.054 13.4 0.4 0.14 12.0 0.4 1.7 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal Kinesin PF00225.23 KOO24649.1 - 2e-84 283.4 0.0 2.5e-84 283.1 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO24649.1 - 8.1e-16 58.3 0.0 1.3e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Casc1_N PF15927.5 KOO24649.1 - 0.22 11.2 3.4 0.42 10.3 3.4 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Rap1a PF18602.1 KOO24654.1 - 0.15 12.4 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 Rap1a immunity proteins LRR_4 PF12799.7 KOO24655.1 - 5.4e-17 61.6 59.4 1.1e-05 25.7 4.7 11.2 8 3 3 11 11 11 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO24655.1 - 1.6e-16 59.8 49.6 3.7e-09 36.2 9.1 9.1 7 3 4 11 11 11 5 Leucine rich repeat Roc PF08477.13 KOO24655.1 - 4.8e-11 42.9 0.0 9.3e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_6 PF13516.6 KOO24655.1 - 1.6e-07 30.8 69.9 0.021 14.9 0.1 15.8 18 0 0 18 18 18 5 Leucine Rich repeat Ras PF00071.22 KOO24655.1 - 0.00037 20.1 0.0 0.00076 19.1 0.0 1.5 1 0 0 1 1 1 1 Ras family LRR_1 PF00560.33 KOO24655.1 - 0.0092 16.4 41.8 12 6.9 0.1 13.1 14 1 0 14 14 14 2 Leucine Rich Repeat DUF1256 PF06866.11 KOO24655.1 - 0.084 12.3 0.1 0.47 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1256) LRR_9 PF14580.6 KOO24655.1 - 0.34 10.4 5.2 0.24 10.9 2.3 2.3 2 0 0 2 2 2 0 Leucine-rich repeat NACHT PF05729.12 KOO24656.1 - 0.0092 15.9 0.1 0.043 13.7 0.1 2.2 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 KOO24656.1 - 0.049 14.0 0.2 0.27 11.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KOO24656.1 - 0.057 13.9 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF512 PF04459.12 KOO24656.1 - 0.088 12.1 0.6 0.22 10.8 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF512) AAA_33 PF13671.6 KOO24657.1 - 1.8e-12 47.7 0.1 2.8e-12 47.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO24657.1 - 0.0053 17.3 0.0 0.01 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOO24657.1 - 0.018 14.8 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KOO24657.1 - 0.021 15.1 0.0 0.043 14.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 KOO24657.1 - 0.037 13.5 0.0 7.9 5.8 0.0 2.2 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Glyco_hydro_30 PF02055.16 KOO24658.1 - 2.2e-71 240.7 0.4 3e-71 240.2 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 KOO24658.1 - 6.9e-06 25.5 0.6 1.2e-05 24.7 0.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 RicinB_lectin_2 PF14200.6 KOO24658.1 - 1.6e-05 25.5 0.0 0.0003 21.4 0.1 2.6 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 KOO24658.1 - 1.6e-05 25.1 0.0 0.0085 16.3 0.0 2.9 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain Glyco_hydro_30C PF17189.4 KOO24658.1 - 3.5e-05 23.9 0.1 7.1e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Peptidase_M14 PF00246.24 KOO24659.1 - 1.8e-19 70.7 0.0 2.7e-18 66.8 0.0 2.4 2 1 1 3 3 3 1 Zinc carboxypeptidase AstE_AspA PF04952.14 KOO24659.1 - 0.058 12.5 0.1 0.087 11.9 0.1 1.3 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family PH PF00169.29 KOO24660.1 - 0.00048 20.6 0.0 0.00073 20.0 0.0 1.3 1 0 0 1 1 1 1 PH domain DUF3368 PF11848.8 KOO24662.1 - 0.12 12.1 0.2 1.2 9.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3368) Cupin_4 PF08007.12 KOO24664.1 - 1.2e-07 31.5 0.6 3.9e-07 29.8 0.0 2.0 2 1 0 2 2 2 1 Cupin superfamily protein Cupin_8 PF13621.6 KOO24664.1 - 8.3e-07 29.0 0.0 3.5e-06 26.9 0.0 1.9 1 1 0 2 2 2 1 Cupin-like domain AraC_binding PF02311.19 KOO24664.1 - 0.062 13.2 0.1 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 AraC-like ligand binding domain HECT PF00632.25 KOO24665.1 - 2.8e-88 296.4 0.0 3.7e-88 295.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 KOO24665.1 - 1.8e-13 50.5 1.6 4.4e-13 49.2 1.6 1.7 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A QRPTase_C PF01729.19 KOO24666.1 - 1.2e-52 178.1 0.0 1.9e-52 177.5 0.0 1.3 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 KOO24666.1 - 6e-17 61.5 0.0 1.4e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain DUF3110 PF11360.8 KOO24668.1 - 4.4e-17 62.1 0.0 4.4e-12 46.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3110) Metallophos PF00149.28 KOO24668.1 - 0.00065 20.2 0.4 0.002 18.7 0.4 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Antimicrobial_6 PF08036.11 KOO24668.1 - 0.2 11.8 1.1 0.57 10.3 0.0 2.2 2 0 0 2 2 2 0 Diapausin family of antimicrobial peptide ParBc PF02195.18 KOO24670.1 - 0.12 12.7 0.2 0.33 11.3 0.0 1.8 2 0 0 2 2 2 0 ParB-like nuclease domain THF_DHG_CYH PF00763.23 KOO24671.1 - 1.7e-23 83.1 0.0 3.3e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 KOO24671.1 - 3.3e-15 55.8 2.1 2.2e-12 46.6 2.1 3.0 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain CdiI_N PF18228.1 KOO24671.1 - 0.19 11.6 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 CdiI N-terminal domain EF-hand_6 PF13405.6 KOO24672.1 - 5e-15 54.1 0.2 4.6e-07 29.3 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO24672.1 - 1.7e-13 49.1 0.5 7.6e-06 25.1 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO24672.1 - 2e-13 49.2 0.7 1.8e-06 27.2 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO24672.1 - 8.1e-10 39.0 0.0 0.0017 18.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO24672.1 - 1.3e-08 34.6 0.3 0.00024 20.9 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO24672.1 - 0.12 12.8 0.0 10 6.5 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO24672.1 - 0.24 11.4 0.0 0.34 10.9 0.0 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand MCM PF00493.23 KOO24673.1 - 1.7e-74 249.7 0.1 2.6e-74 249.1 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOO24673.1 - 9.2e-26 90.2 1.0 1.8e-25 89.2 1.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOO24673.1 - 5.8e-18 65.1 2.5 1.4e-17 63.9 2.5 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 KOO24673.1 - 3.3e-08 33.2 0.2 3e-05 23.5 0.0 2.7 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOO24673.1 - 9.1e-08 32.2 0.0 1.9e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 KOO24673.1 - 3.7e-05 23.5 0.1 0.0019 18.0 0.1 2.5 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 KOO24673.1 - 0.00082 19.2 0.0 0.002 18.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) C1_4 PF07975.12 KOO24673.1 - 0.012 15.9 0.1 0.043 14.1 0.1 1.9 1 0 0 1 1 1 0 TFIIH C1-like domain AAA_30 PF13604.6 KOO24673.1 - 0.018 14.8 1.0 0.066 12.9 1.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOO24673.1 - 0.056 13.7 0.5 0.35 11.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO24673.1 - 0.058 13.8 0.5 0.058 13.8 0.5 2.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 KOO24673.1 - 0.065 13.8 0.1 1 9.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KOO24673.1 - 0.077 13.4 0.1 0.23 11.9 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) VWA_3 PF13768.6 KOO24673.1 - 0.078 12.9 0.1 0.23 11.4 0.1 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain AAA_7 PF12775.7 KOO24673.1 - 0.18 11.3 0.1 0.4 10.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region OTU PF02338.19 KOO24674.1 - 5.9e-08 33.3 0.0 9e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease UIM PF02809.20 KOO24674.1 - 0.077 13.0 1.7 0.15 12.1 1.7 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif zf-C2H2_2 PF12756.7 KOO24674.1 - 0.15 12.4 0.1 0.27 11.6 0.1 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) VWA_2 PF13519.6 KOO24675.1 - 2.8e-10 40.8 0.0 4.3e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 KOO24675.1 - 5.3e-08 33.3 0.0 6.4e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain TssR PF17643.1 KOO24675.1 - 0.00039 18.5 0.0 0.00046 18.3 0.0 1.0 1 0 0 1 1 1 1 Type VI secretion system, TssR Med25_VWA PF11265.8 KOO24675.1 - 0.0066 16.3 0.0 0.014 15.2 0.0 1.7 1 1 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A VWA_3 PF13768.6 KOO24675.1 - 0.022 14.7 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain DEAD PF00270.29 KOO24676.1 - 3.9e-31 108.1 0.0 3.1e-29 102.0 0.0 2.5 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO24676.1 - 2.4e-19 69.7 0.0 1.1e-18 67.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain IATP PF04568.12 KOO24676.1 - 0.026 14.9 3.2 0.072 13.5 3.2 1.8 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP DUF3926 PF13080.6 KOO24676.1 - 0.45 10.5 1.0 2.3 8.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3926) HSP70 PF00012.20 KOO24678.1 - 8.6e-66 222.4 0.0 1.8e-64 218.0 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 KOO24678.1 - 2.7e-14 52.8 0.4 4.1e-12 45.6 0.0 2.5 3 0 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.6 KOO24678.1 - 0.01 16.2 0.0 2.5 8.6 0.0 2.6 2 1 0 2 2 2 0 Cell division protein FtsA Transket_pyr PF02779.24 KOO24679.1 - 4.4e-66 221.9 0.0 9.2e-66 220.9 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 KOO24679.1 - 3.3e-65 220.0 0.0 5.2e-65 219.4 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 KOO24679.1 - 5.4e-52 175.5 0.0 9.5e-52 174.7 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 KOO24679.1 - 3.3e-19 68.2 0.6 7.4e-19 67.1 0.6 1.7 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus PI-TkoII_IV PF18714.1 KOO24679.1 - 0.078 12.4 0.1 0.34 10.4 0.0 2.0 1 1 1 2 2 2 0 DNA polymerase II intein Domain IV WD40 PF00400.32 KOO24680.1 - 2.3e-61 202.3 32.0 1.2e-08 35.5 0.3 8.7 8 0 0 8 8 8 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO24680.1 - 2e-14 53.3 8.2 0.2 10.6 0.1 6.2 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO24680.1 - 5.8e-14 52.2 7.2 0.3 11.4 0.0 7.6 3 3 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO24680.1 - 1.9e-10 40.4 4.5 7.2 6.7 0.0 6.6 6 0 0 6 6 6 5 WD40-like Beta Propeller Repeat AAA_16 PF13191.6 KOO24680.1 - 8.2e-08 32.8 0.1 2e-07 31.6 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 KOO24680.1 - 2.4e-06 27.6 0.0 4.6e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain APAF1_C PF17908.1 KOO24680.1 - 2.5e-05 24.3 0.1 8.8e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 APAF-1 helical domain Frtz PF11768.8 KOO24680.1 - 0.00022 19.7 0.0 3.2 5.9 0.0 3.8 2 1 2 4 4 4 3 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO24680.1 - 0.00067 19.1 4.5 6.8 5.9 0.0 4.7 1 1 4 5 5 5 2 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 KOO24680.1 - 0.036 13.4 1.5 5.9 6.1 0.0 4.3 3 2 1 4 4 4 0 WD40-like domain WD40_3 PF15911.5 KOO24680.1 - 0.043 13.8 2.2 2.5e+02 1.7 0.0 5.8 7 0 0 7 7 7 0 WD domain, G-beta repeat KAP_NTPase PF07693.14 KOO24680.1 - 0.058 12.6 0.0 0.44 9.7 0.0 2.0 1 1 1 2 2 2 0 KAP family P-loop domain NHL PF01436.21 KOO24681.1 - 5.7e-25 86.1 0.4 2.4e-06 27.3 0.0 5.4 5 0 0 5 5 5 4 NHL repeat SGL PF08450.12 KOO24681.1 - 4.5e-09 36.3 0.1 0.0005 19.7 0.1 3.9 3 2 0 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 KOO24681.1 - 0.00035 20.6 0.0 1.8 8.5 0.0 3.5 3 1 1 4 4 4 2 Esterase-like activity of phytase Ribosomal_60s PF00428.19 KOO24681.1 - 0.71 10.5 8.1 1.3 9.6 1.0 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Glyco_transf_20 PF00982.21 KOO24682.1 - 2.3e-96 323.3 0.0 7.7e-58 196.3 0.0 3.2 3 0 0 3 3 3 3 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOO24682.1 - 7.2e-32 110.4 0.0 1.1e-31 109.8 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase HlyIII PF03006.20 KOO24683.1 - 7.9e-19 68.3 12.4 9.7e-19 68.0 12.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF1129 PF06570.11 KOO24683.1 - 0.022 14.3 1.4 0.034 13.6 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Myosin_head PF00063.21 KOO24684.1 - 7.1e-151 503.7 0.0 4.3e-68 230.1 0.0 3.0 2 1 1 3 3 3 3 Myosin head (motor domain) WW PF00397.26 KOO24684.1 - 2.7e-10 40.2 5.0 1.7e-07 31.2 0.5 2.7 2 0 0 2 2 2 2 WW domain IQ PF00612.27 KOO24684.1 - 0.0013 18.3 18.5 0.0053 16.4 1.6 4.9 4 0 0 4 4 4 2 IQ calmodulin-binding motif AAA_16 PF13191.6 KOO24684.1 - 0.0058 17.0 0.1 0.027 14.9 0.1 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOO24684.1 - 0.053 13.8 0.1 0.33 11.2 0.1 2.3 2 0 0 2 2 2 0 AAA domain Tubulin PF00091.25 KOO24685.1 - 4.9e-31 108.5 0.1 1.5e-30 106.9 0.1 1.8 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.8 KOO24685.1 - 0.00014 22.1 2.4 0.00039 20.7 0.0 2.8 3 0 0 3 3 3 1 FtsZ family, C-terminal domain Tubulin_2 PF13809.6 KOO24685.1 - 0.0083 15.3 0.8 0.39 9.8 0.8 2.2 1 1 0 1 1 1 1 Tubulin like CO_deh_flav_C PF03450.17 KOO24685.1 - 0.025 14.7 0.1 0.025 14.7 0.1 2.8 3 0 0 3 3 3 0 CO dehydrogenase flavoprotein C-terminal domain Ank_2 PF12796.7 KOO24686.1 - 2.5e-13 50.4 2.0 3.6e-09 37.1 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO24686.1 - 3.6e-11 43.3 1.7 3.7e-06 27.4 0.1 3.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24686.1 - 3.9e-09 36.0 1.9 0.00027 21.1 0.0 4.6 5 1 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 KOO24686.1 - 2.6e-08 34.0 3.7 0.002 18.5 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOO24686.1 - 8.2e-05 22.8 2.8 0.0096 16.2 0.1 3.5 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Beta_helix PF13229.6 KOO24687.1 - 1e-20 74.2 12.4 2.8e-17 63.0 5.6 2.3 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.13 KOO24687.1 - 2.1e-13 50.1 0.2 1.4e-07 31.0 0.0 2.1 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.11 KOO24687.1 - 2.7e-05 23.6 1.9 0.057 12.8 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF1565) Big_11 PF18200.1 KOO24687.1 - 0.13 12.2 0.0 3 7.8 0.0 2.4 1 1 1 2 2 2 0 Bacterial Ig-like domain NT-C2 PF10358.9 KOO24688.1 - 8.9e-08 32.0 0.0 7.4e-07 29.0 0.0 2.1 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins ABC_tran PF00005.27 KOO24689.1 - 9.6e-05 22.9 0.0 0.00026 21.5 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 KOO24689.1 - 0.15 11.5 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain EamA PF00892.20 KOO24690.1 - 4.3e-06 26.9 13.3 4.3e-06 26.9 13.3 2.2 2 0 0 2 2 2 1 EamA-like transporter family Sulfotransfer_3 PF13469.6 KOO24690.1 - 0.00078 19.9 0.0 0.0013 19.2 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO24690.1 - 0.18 11.2 0.0 0.29 10.6 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase domain Sec20 PF03908.13 KOO24691.1 - 1.7e-19 69.5 0.0 3.7e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Sec20 DUF5561 PF17716.1 KOO24691.1 - 3.2e-10 39.7 0.0 0.004 16.5 0.0 3.3 3 0 0 3 3 3 3 Family of unknown function (DUF5561) Syntaxin-6_N PF09177.11 KOO24691.1 - 0.48 11.0 4.4 15 6.2 0.7 2.9 2 0 0 2 2 2 0 Syntaxin 6, N-terminal CAP_N PF01213.19 KOO24692.1 - 4.2 6.8 4.5 5.8 6.3 4.5 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Ion_trans PF00520.31 KOO24693.1 - 7.4e-16 58.1 7.7 1.1e-15 57.5 7.7 1.2 1 0 0 1 1 1 1 Ion transport protein Atx10homo_assoc PF09759.9 KOO24694.1 - 1.9e-26 92.0 0.1 2.8e-26 91.4 0.1 1.3 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO24694.1 - 0.023 14.2 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Armadillo-like LRR_6 PF13516.6 KOO24696.1 - 1.9e-12 46.1 8.8 4.2e-06 26.4 0.1 6.7 6 0 0 6 6 6 2 Leucine Rich repeat EF-hand_1 PF00036.32 KOO24696.1 - 1.6e-10 39.8 1.5 3.6e-05 23.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO24696.1 - 5e-09 36.5 0.2 1.2e-08 35.3 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO24696.1 - 4.2e-08 32.5 0.4 0.0018 18.0 0.3 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_9 PF14658.6 KOO24696.1 - 1.1e-05 25.7 0.0 2.9e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO24696.1 - 3e-05 23.3 3.0 0.025 14.1 0.0 2.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO24696.1 - 5e-05 23.1 2.0 0.00013 21.7 0.6 2.4 1 1 1 2 2 2 1 EF-hand domain pair LRR_1 PF00560.33 KOO24696.1 - 0.0013 19.0 5.3 7.2 7.6 0.0 6.0 7 0 0 7 7 6 1 Leucine Rich Repeat SAM_2 PF07647.17 KOO24696.1 - 0.002 18.2 0.0 0.011 15.9 0.0 2.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) LRR_4 PF12799.7 KOO24696.1 - 0.0047 17.3 0.4 44 4.7 0.0 5.1 4 2 1 5 5 5 0 Leucine Rich repeats (2 copies) SAM_1 PF00536.30 KOO24696.1 - 0.0052 17.2 0.0 0.11 13.0 0.0 2.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) UPF0561 PF10573.9 KOO24696.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Aa_trans PF01490.18 KOO24697.1 - 8.5e-64 215.8 15.7 1.5e-63 214.9 15.7 1.4 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOO24697.1 - 1.4e-07 31.0 6.1 3.3e-07 29.7 6.1 1.6 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family DUF1780 PF08682.10 KOO24698.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Putative endonuclease, protein of unknown function (DUF1780) Nucleotid_trans PF03407.16 KOO24699.1 - 8.8e-08 32.4 0.0 1.3e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Castor_Poll_mid PF06241.12 KOO24700.1 - 1.2e-29 102.3 0.0 7.6e-28 96.5 0.0 2.4 2 0 0 2 2 2 1 Castor and Pollux, part of voltage-gated ion channel TrkA_C PF02080.21 KOO24700.1 - 0.0064 16.3 0.0 0.033 14.0 0.0 2.3 1 0 0 1 1 1 1 TrkA-C domain TrkA_N PF02254.18 KOO24700.1 - 0.024 14.9 1.9 0.056 13.7 0.2 2.4 2 0 0 2 2 2 0 TrkA-N domain Prok-E2_C PF14459.6 KOO24702.1 - 0.16 12.2 1.2 6.1 7.0 0.0 2.2 2 0 0 2 2 2 0 Prokaryotic E2 family C NHL PF01436.21 KOO24703.1 - 3.7e-07 29.9 9.0 0.01 15.9 0.0 5.9 6 0 0 6 6 6 3 NHL repeat Lactonase PF10282.9 KOO24703.1 - 0.0022 17.3 0.0 0.0071 15.7 0.0 1.8 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller PQQ_3 PF13570.6 KOO24703.1 - 0.1 13.1 3.4 2.1 8.9 0.0 3.7 4 0 0 4 4 4 0 PQQ-like domain LRR_4 PF12799.7 KOO24704.1 - 3e-10 40.2 1.7 2.5e-05 24.5 0.0 2.7 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO24704.1 - 2.2e-08 33.8 0.1 5.1e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_6 PF13516.6 KOO24704.1 - 0.0031 17.4 0.3 0.28 11.3 0.0 3.5 3 0 0 3 3 3 1 Leucine Rich repeat LRR_1 PF00560.33 KOO24704.1 - 0.013 16.0 0.5 0.46 11.2 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich Repeat DUF5362 PF17319.2 KOO24704.1 - 0.061 13.2 0.4 0.13 12.1 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5362) TRP PF06011.12 KOO24704.1 - 0.1 11.3 0.2 0.14 10.8 0.2 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Pkinase PF00069.25 KOO24706.1 - 3.1e-56 190.7 0.0 4e-56 190.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24706.1 - 9.6e-30 103.7 0.0 1.4e-29 103.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO24706.1 - 1.8e-05 23.9 0.0 2.4e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KOO24706.1 - 7.1e-05 22.0 0.2 0.00028 20.1 0.1 1.8 1 1 1 2 2 2 1 Seadornavirus VP7 Kinase-like PF14531.6 KOO24706.1 - 0.00017 21.0 0.1 0.015 14.7 0.1 2.3 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.22 KOO24706.1 - 0.00024 20.7 0.0 0.00037 20.1 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KOO24706.1 - 0.029 14.3 0.2 0.065 13.1 0.2 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO24706.1 - 0.24 10.7 0.0 0.37 10.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Herpes_UL51 PF04540.13 KOO24707.1 - 0.0023 17.7 0.1 0.0052 16.5 0.1 1.6 1 0 0 1 1 1 1 Herpesvirus UL51 protein Vps26 PF03643.15 KOO24708.1 - 1.3e-113 378.6 2.1 1.5e-113 378.4 2.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 KOO24708.1 - 1.8e-06 28.1 1.1 0.012 15.6 0.1 3.1 2 1 1 3 3 3 2 Arrestin (or S-antigen), N-terminal domain SGS PF05002.15 KOO24709.1 - 6.8e-29 99.8 6.8 1.6e-28 98.6 6.8 1.7 1 0 0 1 1 1 1 SGS domain CS PF04969.16 KOO24709.1 - 1.8e-15 57.7 1.1 2.8e-15 57.1 1.1 1.3 1 0 0 1 1 1 1 CS domain TPR_1 PF00515.28 KOO24709.1 - 6.3e-12 44.8 7.6 0.00018 21.2 0.2 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO24709.1 - 2.5e-11 42.8 10.2 5.6e-05 22.9 0.7 3.9 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO24709.1 - 3.6e-11 42.6 4.3 2.7e-07 30.1 0.3 2.6 2 0 0 2 2 2 2 TPR repeat TPR_16 PF13432.6 KOO24709.1 - 2.8e-08 34.3 11.0 1.8e-06 28.5 0.7 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO24709.1 - 8.8e-08 32.5 3.6 0.00014 22.3 0.3 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO24709.1 - 1.2e-07 31.4 6.1 0.00024 21.1 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO24709.1 - 0.0002 21.9 6.8 0.14 13.0 0.7 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO24709.1 - 0.00077 19.7 6.6 0.33 11.3 0.8 2.9 1 1 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO24709.1 - 0.001 19.3 2.9 0.002 18.3 2.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KOO24709.1 - 0.0019 18.4 0.7 0.0078 16.5 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO24709.1 - 0.0034 17.5 3.1 0.52 10.5 0.5 2.4 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_20 PF14561.6 KOO24709.1 - 0.053 13.9 6.7 0.23 11.8 2.8 3.3 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO24709.1 - 0.055 13.5 5.1 9 6.6 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4241 PF14025.6 KOO24709.1 - 0.17 12.1 1.1 6.2 7.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4241) TPR_10 PF13374.6 KOO24709.1 - 0.24 11.3 1.5 11 6.0 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO24709.1 - 3 8.7 5.7 8.2 7.3 0.9 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Kinesin PF00225.23 KOO24710.1 - 6.5e-56 189.7 0.0 8.4e-56 189.3 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO24710.1 - 3.7e-10 39.9 0.0 6.5e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding zf-C3HC4_3 PF13920.6 KOO24710.1 - 0.00014 21.6 7.8 0.00028 20.7 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO24710.1 - 0.00024 20.9 8.8 0.00024 20.9 8.8 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO24710.1 - 0.00059 19.6 8.0 0.0013 18.5 8.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO24710.1 - 0.00082 19.7 8.4 0.0022 18.3 8.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KOO24710.1 - 0.0015 18.5 6.5 0.0035 17.3 6.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 KOO24710.1 - 0.0037 17.1 4.9 0.0082 16.0 4.9 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein DZR PF12773.7 KOO24710.1 - 0.06 13.4 3.6 0.15 12.1 3.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon Prok-RING_4 PF14447.6 KOO24710.1 - 0.073 12.9 8.3 0.14 12.0 8.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 TackOD1 PF18551.1 KOO24710.1 - 0.097 12.3 3.2 0.18 11.4 3.2 1.4 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 zf-rbx1 PF12678.7 KOO24710.1 - 0.14 12.4 3.4 0.43 10.9 3.4 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KOO24710.1 - 0.25 11.4 6.8 0.078 13.0 3.3 2.0 1 1 0 1 1 1 0 RING-type zinc-finger PqiA PF04403.13 KOO24711.1 - 5e-09 36.2 22.8 5e-05 23.2 9.3 3.0 2 1 0 2 2 2 2 Paraquat-inducible protein A Proteasome PF00227.26 KOO24712.1 - 5.9e-52 175.9 0.1 7e-52 175.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOO24712.1 - 2.7e-12 46.1 0.0 4.7e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF2267 PF10025.9 KOO24715.1 - 0.15 12.4 1.5 26 5.1 0.2 3.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2267) Kinesin PF00225.23 KOO24716.1 - 2e-82 276.8 0.0 6.5e-82 275.1 0.0 1.9 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO24716.1 - 1.4e-26 93.2 0.0 4e-26 91.7 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding AdoHcyase_NAD PF00670.21 KOO24716.1 - 0.072 13.2 0.1 0.2 11.7 0.1 1.7 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain TIR PF01582.20 KOO24716.1 - 6.4 6.5 9.0 0.3 10.9 2.8 2.0 2 1 0 2 2 2 0 TIR domain EF-hand_7 PF13499.6 KOO24717.1 - 6.9e-08 32.8 0.0 1.5e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO24717.1 - 8.3e-08 31.6 0.6 7e-05 22.4 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO24717.1 - 1.4e-06 27.4 0.0 0.00013 21.3 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO24717.1 - 0.00011 21.5 0.1 0.00034 20.0 0.0 1.9 2 0 0 2 2 2 1 EF hand Methyltransf_21 PF05050.12 KOO24719.1 - 5.3e-05 23.3 0.0 8.4e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase FkbM domain EF-hand_7 PF13499.6 KOO24720.1 - 0.014 15.8 0.0 0.14 12.6 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 KOO24720.1 - 0.02 14.4 0.3 0.065 12.7 0.0 2.0 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.32 KOO24721.1 - 3.5e-10 38.7 0.2 1.7e-05 24.0 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO24721.1 - 4.4e-09 35.4 1.1 0.0031 16.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO24721.1 - 1.1e-08 35.4 0.3 2.3e-08 34.3 0.3 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO24721.1 - 5.8e-07 28.9 0.2 0.038 13.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO24721.1 - 2.5e-05 24.1 0.8 0.0034 17.2 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO24721.1 - 0.0056 17.0 0.1 0.0079 16.5 0.1 1.1 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Pro_isomerase PF00160.21 KOO24722.1 - 6.9e-50 169.4 0.0 1.5e-49 168.3 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 KOO24722.1 - 2.1e-05 24.0 0.3 9.9e-05 21.8 0.1 2.1 2 1 0 2 2 2 1 Rtf2 RING-finger zf-NOSIP PF15906.5 KOO24722.1 - 0.00046 20.3 0.1 0.002 18.2 0.0 2.1 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein PC-Esterase PF13839.6 KOO24723.1 - 0.0015 18.3 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p DUF3291 PF11695.8 KOO24724.1 - 0.031 13.9 0.1 1.2 8.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3291) Methyltransf_21 PF05050.12 KOO24725.1 - 1e-11 45.2 0.0 1.7e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain LRV_FeS PF05484.11 KOO24725.1 - 0.013 15.5 1.1 0.023 14.7 0.4 1.7 2 0 0 2 2 2 0 LRV protein FeS4 cluster Filament PF00038.21 KOO24727.1 - 0.01 15.4 43.6 0.027 14.0 20.6 3.5 1 1 2 3 3 3 0 Intermediate filament protein DUF1664 PF07889.12 KOO24727.1 - 0.028 14.4 0.4 0.028 14.4 0.4 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.8 KOO24727.1 - 0.069 13.2 40.0 0.62 10.1 9.0 4.2 2 1 3 5 5 5 0 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.12 KOO24727.1 - 0.44 10.6 24.5 1.5 8.8 6.7 3.9 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus YabA PF06156.13 KOO24727.1 - 0.46 11.1 21.6 1.9 9.1 4.2 3.4 2 1 1 3 3 3 0 Initiation control protein YabA cwf21 PF08312.12 KOO24727.1 - 0.5 10.6 0.2 0.5 10.6 0.2 4.4 2 2 1 3 3 3 0 cwf21 domain ATG16 PF08614.11 KOO24727.1 - 0.64 10.2 55.7 0.095 12.9 25.3 3.2 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) T3SS_needle_F PF09392.10 KOO24727.1 - 2.5 8.4 25.2 0.7 10.1 0.6 4.8 2 2 3 5 5 5 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF XLF PF09302.11 KOO24727.1 - 5.4 7.2 13.2 1.3 9.2 5.8 2.2 1 1 1 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component CHMI PF02962.15 KOO24727.1 - 8.5 6.7 9.0 0.89 9.9 2.0 2.5 1 1 2 3 3 3 0 5-carboxymethyl-2-hydroxymuconate isomerase Glucosaminidase PF01832.20 KOO24727.1 - 9.5 6.8 11.2 37 4.9 0.1 3.7 3 1 1 4 4 4 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase EF-hand_6 PF13405.6 KOO24728.1 - 1.6e-22 77.4 0.1 0.00017 21.3 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO24728.1 - 1.7e-18 64.7 1.0 0.00044 19.6 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO24728.1 - 6.2e-17 61.8 5.0 4.9e-07 30.1 0.1 4.6 2 1 3 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO24728.1 - 1.8e-08 33.5 7.3 0.0035 16.8 0.1 4.3 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO24728.1 - 6.6e-08 32.3 1.6 0.32 10.9 0.0 3.9 2 1 1 3 3 3 3 EF-hand domain pair NCE101 PF11654.8 KOO24728.1 - 0.004 16.8 0.0 36 4.2 0.0 4.8 4 0 0 4 4 4 0 Non-classical export protein 1 TPT PF03151.16 KOO24729.1 - 4e-09 36.2 14.2 1.6e-08 34.3 14.2 1.8 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO24729.1 - 2.1 8.5 25.2 4.2 7.5 10.8 2.5 2 0 0 2 2 2 0 EamA-like transporter family WD40 PF00400.32 KOO24730.1 - 1.5e-06 28.8 3.4 0.13 13.2 0.0 4.9 6 0 0 6 6 6 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO24730.1 - 7.6e-05 21.8 0.3 1 8.2 0.1 3.8 3 1 0 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO24730.1 - 0.0023 18.2 0.0 1.3 9.3 0.0 4.6 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KOO24730.1 - 0.1 13.1 9.2 33 5.2 0.1 5.3 5 0 0 5 5 5 0 PQQ-like domain Gp_dh_C PF02800.20 KOO24731.1 - 9.1e-24 83.8 0.0 1.3e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KOO24731.1 - 4.9e-18 65.3 0.0 8e-18 64.7 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain SQS_PSY PF00494.19 KOO24732.1 - 9.3e-28 97.4 0.0 4.8e-27 95.1 0.0 2.0 2 1 0 2 2 2 1 Squalene/phytoene synthase NUDIX PF00293.28 KOO24732.1 - 1.1e-16 61.1 0.0 2.3e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain tRNA-synt_2 PF00152.20 KOO24733.1 - 7.3e-78 261.8 0.0 9.6e-78 261.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOO24733.1 - 9.7e-16 57.5 0.0 1.1e-14 54.2 0.0 2.2 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain WHEP-TRS PF00458.20 KOO24733.1 - 2.6e-10 40.3 4.5 5.5e-10 39.2 4.5 1.6 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_2d PF01409.20 KOO24733.1 - 0.00068 19.2 0.0 0.2 11.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DEC-1_N PF04625.13 KOO24733.1 - 0.0092 15.0 2.1 0.014 14.4 2.1 1.2 1 0 0 1 1 1 1 DEC-1 protein, N-terminal region RuvC PF02075.17 KOO24733.1 - 0.018 14.9 0.7 0.066 13.1 0.5 1.9 2 0 0 2 2 2 0 Crossover junction endodeoxyribonuclease RuvC DUF4054 PF13262.6 KOO24733.1 - 0.51 10.4 3.1 3.7 7.6 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4054) G_glu_transpept PF01019.21 KOO24734.1 - 1.7e-55 188.8 0.0 9.5e-55 186.3 0.0 1.8 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase LRR_6 PF13516.6 KOO24735.1 - 3.2e-28 95.3 14.3 0.0016 18.3 0.2 9.7 9 0 0 9 9 9 8 Leucine Rich repeat DUF4476 PF14771.6 KOO24735.1 - 3.6e-13 49.6 0.5 6.9e-13 48.7 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) LRR_4 PF12799.7 KOO24735.1 - 0.0068 16.8 6.1 5.3 7.6 0.5 4.1 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO24735.1 - 0.3 10.9 11.2 11 5.8 1.8 5.2 3 1 2 5 5 5 0 Leucine rich repeat Ribosomal_L1 PF00687.21 KOO24737.1 - 3.7e-48 164.0 0.0 6.3e-48 163.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family EF-hand_1 PF00036.32 KOO24738.1 - 9.2e-10 37.4 7.7 2.4e-05 23.5 0.1 4.8 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.6 KOO24738.1 - 5.6e-08 31.9 0.8 0.0079 15.7 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO24738.1 - 1.3e-07 32.0 1.4 1.5e-06 28.6 0.0 3.0 2 2 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO24738.1 - 1.4e-07 30.9 0.1 0.091 12.7 0.0 4.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO24738.1 - 3.1e-05 23.7 0.1 0.2 11.5 0.0 2.9 1 1 1 2 2 2 2 EF-hand domain pair TerB PF05099.13 KOO24738.1 - 0.056 13.4 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 Tellurite resistance protein TerB EF-hand_4 PF12763.7 KOO24738.1 - 0.38 10.7 3.1 0.96 9.4 0.0 3.0 2 2 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand CIA30 PF08547.12 KOO24739.1 - 1.2e-05 25.4 0.0 0.00024 21.1 0.0 2.2 2 0 0 2 2 2 1 Complex I intermediate-associated protein 30 (CIA30) Zip PF02535.22 KOO24740.1 - 6.1e-07 29.0 0.1 8.4e-07 28.5 0.1 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter MFS_1 PF07690.16 KOO24740.1 - 0.0013 17.8 0.5 0.0018 17.3 0.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily NHL PF01436.21 KOO24740.1 - 0.0021 18.0 0.0 0.034 14.2 0.0 2.8 2 0 0 2 2 2 1 NHL repeat HlyIII PF03006.20 KOO24740.1 - 0.069 12.9 0.2 0.11 12.2 0.2 1.2 1 0 0 1 1 1 0 Haemolysin-III related NEMP PF10225.9 KOO24740.1 - 0.2 11.3 0.2 0.31 10.7 0.2 1.2 1 0 0 1 1 1 0 NEMP family SelR PF01641.18 KOO24741.1 - 8.1e-38 129.2 1.4 1e-37 128.9 1.4 1.0 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 KOO24741.1 - 0.023 14.4 0.9 0.3 10.8 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 KOO24741.1 - 0.082 13.1 1.6 0.2 11.9 1.6 1.7 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-Mss51 PF13824.6 KOO24741.1 - 0.11 12.6 0.3 0.11 12.6 0.3 2.4 1 1 2 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-ribbon_3 PF13248.6 KOO24741.1 - 1.1 8.8 7.1 12 5.5 0.2 3.6 4 0 0 4 4 4 0 zinc-ribbon domain Ribosomal_L37e PF01907.19 KOO24741.1 - 1.3 9.2 7.4 0.2 11.9 2.3 2.2 2 1 0 2 2 2 0 Ribosomal protein L37e DUF2757 PF10955.8 KOO24741.1 - 1.7 8.9 4.1 8.9 6.7 2.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2757) SPC25 PF06703.11 KOO24742.1 - 6.2e-26 91.1 0.0 5.5e-25 88.0 0.0 1.9 1 1 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Methyltransf_11 PF08241.12 KOO24743.1 - 0.00021 21.9 0.0 0.00035 21.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO24743.1 - 0.015 15.1 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 KOO24743.1 - 0.073 13.8 0.0 0.13 12.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain SpoU_methylase PF00588.19 KOO24744.1 - 1.6e-24 86.7 0.0 1.4e-23 83.7 0.0 1.9 2 0 0 2 2 2 1 SpoU rRNA Methylase family CortBP2 PF09727.9 KOO24745.1 - 1.4e-06 28.4 58.9 0.057 13.3 11.6 4.7 1 1 4 5 5 5 5 Cortactin-binding protein-2 Csd3_N PF18059.1 KOO24745.1 - 0.019 15.5 10.6 24 5.5 0.0 6.4 1 1 8 9 9 9 0 Csd3 N-terminal APG6_N PF17675.1 KOO24745.1 - 0.036 14.6 66.2 0.77 10.3 13.4 4.6 1 1 2 3 3 3 0 Apg6 coiled-coil region MCPVI PF02993.14 KOO24745.1 - 0.089 12.6 19.9 4.5 7.0 0.3 6.3 1 1 5 6 6 6 0 Minor capsid protein VI TetR_C_24 PF17932.1 KOO24745.1 - 0.61 10.4 38.5 3.9 7.8 1.0 8.9 3 2 5 9 9 9 0 Tetracyclin repressor-like, C-terminal domain EspB_PE PF18625.1 KOO24745.1 - 4.8 7.7 60.8 2.1 8.9 1.8 9.0 2 1 11 13 13 13 0 ESX-1 secreted protein B PE domain Antirestrict PF03230.13 KOO24746.1 - 0.082 13.0 1.7 0.24 11.5 1.7 1.8 1 0 0 1 1 1 0 Antirestriction protein DUF4263 PF14082.6 KOO24746.1 - 0.21 11.8 0.3 0.31 11.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4263) DUF3347 PF11827.8 KOO24746.1 - 0.96 9.6 23.0 0.86 9.8 6.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) TFIIA PF03153.13 KOO24746.1 - 1.1 9.1 7.9 1.4 8.9 7.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 KOO24746.1 - 4.9 4.9 11.1 6.5 4.5 11.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NYN PF01936.18 KOO24747.1 - 2.9e-11 44.0 0.0 3.7e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 NYN domain Het-C PF07217.11 KOO24748.1 - 0.0078 14.8 0.8 0.015 13.9 0.0 1.7 1 1 1 2 2 2 1 Heterokaryon incompatibility protein Het-C DUF1501 PF07394.12 KOO24748.1 - 1.1 8.3 7.1 1.2 8.1 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) TPR_MLP1_2 PF07926.12 KOO24748.1 - 4.7 7.3 19.1 6.4 6.9 19.1 1.1 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Cofac_haem_bdg PF04187.13 KOO24749.1 - 3.9e-33 115.2 0.1 7e-33 114.4 0.1 1.4 1 0 0 1 1 1 1 Haem-binding uptake, Tiki superfamily, ChaN Methyltransf_11 PF08241.12 KOO24749.1 - 4.8e-20 72.0 0.2 3.6e-19 69.2 0.1 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO24749.1 - 1.3e-19 70.5 0.0 2.2e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO24749.1 - 8.7e-19 68.0 0.3 5.7e-18 65.4 0.1 2.4 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO24749.1 - 6.2e-11 42.1 0.0 1.4e-10 40.9 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 KOO24749.1 - 4.4e-09 37.0 0.0 8.9e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO24749.1 - 1.4e-07 31.5 0.0 2.8e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO24749.1 - 2e-06 27.3 0.0 3e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 KOO24749.1 - 1.2e-05 25.1 0.1 5.4e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.15 KOO24749.1 - 0.00015 21.7 0.0 0.00025 21.0 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_32 PF13679.6 KOO24749.1 - 0.00048 20.2 0.0 0.00092 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO24749.1 - 0.0052 16.2 0.1 0.0081 15.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DOT1 PF08123.13 KOO24749.1 - 0.02 14.4 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.14 KOO24749.1 - 0.047 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain UPF0020 PF01170.18 KOO24749.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 RRM_1 PF00076.22 KOO24750.1 - 0.0017 18.1 0.3 0.04 13.7 0.0 2.5 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1329 PF07044.11 KOO24750.1 - 0.015 14.6 0.1 0.02 14.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1329) NuDC PF16273.5 KOO24750.1 - 2 9.0 6.9 1.5 9.4 1.2 2.7 2 0 0 2 2 2 0 Nuclear distribution C domain AAA_19 PF13245.6 KOO24751.1 - 2.6e-06 27.8 0.5 8.3e-06 26.2 0.5 2.0 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 KOO24751.1 - 0.0026 17.3 0.0 0.0047 16.5 0.0 1.4 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 KOO24751.1 - 0.12 12.7 0.0 0.45 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Tcf25 PF04910.14 KOO24752.1 - 2e-37 129.1 0.0 2.4e-37 128.8 0.0 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Ion_trans PF00520.31 KOO24753.1 - 7.9e-09 35.1 6.6 1.2e-08 34.5 6.6 1.2 1 0 0 1 1 1 1 Ion transport protein DSPc PF00782.20 KOO24753.1 - 6.5e-06 26.0 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KOO24753.1 - 4.5e-05 23.6 0.0 9.5e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 KOO24753.1 - 7.2e-05 22.5 0.0 0.00011 21.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTEN_C2 PF10409.9 KOO24753.1 - 0.00026 20.7 0.1 0.0036 17.1 0.0 2.2 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein Y_phosphatase3 PF13350.6 KOO24753.1 - 0.0007 19.6 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PKD_channel PF08016.12 KOO24753.1 - 0.061 12.0 4.0 0.1 11.2 4.0 1.2 1 0 0 1 1 1 0 Polycystin cation channel SCAMP PF04144.13 KOO24753.1 - 0.11 12.8 7.9 0.22 11.8 7.9 1.4 1 0 0 1 1 1 0 SCAMP family UL42 PF17638.2 KOO24753.1 - 0.11 12.4 0.1 0.11 12.4 0.1 2.5 2 0 0 2 2 2 0 HCMV UL42 DUF3043 PF11241.8 KOO24753.1 - 0.29 11.2 2.0 0.31 11.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) FBPase PF00316.20 KOO24754.1 - 1.3e-61 207.4 0.1 3.2e-61 206.1 0.1 1.6 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain NPL4 PF05021.15 KOO24754.1 - 5e-18 65.5 0.4 6.3e-14 52.0 0.4 3.2 1 1 0 1 1 1 1 NPL4 family UN_NPL4 PF11543.8 KOO24754.1 - 1.5e-05 25.4 0.0 0.00013 22.3 0.0 2.4 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 Aminotran_1_2 PF00155.21 KOO24755.1 - 1.4e-33 116.6 0.0 2.9e-33 115.5 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 KOO24755.1 - 0.0014 17.6 0.0 0.0042 16.0 0.0 1.7 1 1 0 1 1 1 1 Allinase Glyco_transf_18 PF15024.6 KOO24758.1 - 0.01 14.5 1.0 0.0091 14.6 1.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 18 DUF3119 PF11317.8 KOO24759.1 - 7.6e-38 129.6 0.0 1e-37 129.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3119) RNA_pol_Rpb1_1 PF04997.12 KOO24760.1 - 0.0062 15.9 0.2 0.0076 15.6 0.2 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 A_deaminase PF00962.22 KOO24761.1 - 1.1e-05 25.0 0.0 1.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Filamin PF00630.19 KOO24762.1 - 2.4e-59 198.5 0.0 8.7e-20 71.5 0.0 7.4 7 0 0 7 7 7 7 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO24762.1 - 2e-19 69.7 1.5 0.00049 20.4 0.0 6.2 7 1 0 7 7 7 3 Invasin, domain 3 YtkA PF13115.6 KOO24762.1 - 6e-05 23.6 0.2 0.14 12.8 0.0 3.4 3 0 0 3 3 3 2 YtkA-like SH3_3 PF08239.11 KOO24762.1 - 0.00044 20.5 0.0 0.0013 18.9 0.0 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain Y_Y_Y PF07495.13 KOO24762.1 - 0.0025 17.8 0.2 1.4 8.9 0.0 3.9 4 0 0 4 4 4 1 Y_Y_Y domain BclA_C PF18573.1 KOO24762.1 - 0.034 14.0 0.0 1.4 8.8 0.0 3.5 4 0 0 4 4 4 0 BclA C-terminal domain PCC_BT PF18140.1 KOO24762.1 - 0.098 13.0 0.0 17 5.8 0.0 3.8 4 0 0 4 4 4 0 Propionyl-coenzyme A carboxylase BT domain Neurexophilin PF06312.12 KOO24762.1 - 0.15 11.5 0.1 2 7.8 0.0 2.2 2 0 0 2 2 2 0 Neurexophilin DUF1933 PF09147.10 KOO24762.1 - 0.16 11.5 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1933) DUF5011 PF16403.5 KOO24762.1 - 4.6 7.4 4.8 26 5.0 0.2 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) Lectin_leg-like PF03388.13 KOO24764.1 - 0.023 14.1 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Legume-like lectin family Amidohydro_1 PF01979.20 KOO24765.1 - 4.6e-67 226.8 0.3 6.9e-67 226.2 0.3 1.3 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 KOO24765.1 - 4e-50 169.2 2.4 7.1e-50 168.4 2.4 1.4 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_gamma PF00547.18 KOO24765.1 - 7.2e-41 138.5 0.1 7.2e-41 138.5 0.1 2.2 3 0 0 3 3 3 1 Urease, gamma subunit Urease_beta PF00699.20 KOO24765.1 - 2e-39 133.6 0.1 6.1e-39 132.0 0.1 1.9 1 0 0 1 1 1 1 Urease beta subunit Amidohydro_3 PF07969.11 KOO24765.1 - 2e-05 24.3 0.2 0.00017 21.2 0.0 2.2 2 0 0 2 2 2 1 Amidohydrolase family LamB_YcsF PF03746.16 KOO24765.1 - 0.046 13.4 0.6 0.11 12.1 0.2 1.8 2 0 0 2 2 2 0 LamB/YcsF family CX9C PF16860.5 KOO24766.1 - 0.0062 16.5 0.9 1.3 9.0 0.2 2.3 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, WD40 PF00400.32 KOO24767.1 - 7.7e-15 55.0 4.8 0.0069 17.2 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat Sm_multidrug_ex PF06695.11 KOO24768.1 - 2.5e-19 70.1 1.2 2.5e-19 70.1 1.2 1.8 2 0 0 2 2 2 1 Putative small multi-drug export protein HCV_NS4a PF01006.20 KOO24768.1 - 0.21 11.4 2.2 0.13 12.0 0.5 1.6 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a CN_hydrolase PF00795.22 KOO24769.1 - 6.4e-15 55.2 0.0 1e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_binding_8 PF13450.6 KOO24769.1 - 5.6e-10 39.3 0.2 1.8e-09 37.7 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KOO24769.1 - 7.4e-08 32.1 0.1 1.9e-06 27.5 0.0 2.2 1 1 1 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 KOO24769.1 - 0.0075 16.3 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pkinase_Tyr PF07714.17 KOO24770.1 - 5.9e-38 130.6 0.0 1.9e-37 129.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO24770.1 - 4.4e-37 127.9 0.0 6.9e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SKG6 PF08693.10 KOO24770.1 - 0.0028 17.0 3.7 0.0065 15.9 3.7 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 KOO24770.1 - 0.017 14.9 0.4 0.031 14.1 0.4 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Gram_pos_anchor PF00746.21 KOO24770.1 - 0.044 13.7 0.4 0.095 12.7 0.4 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Syndecan PF01034.20 KOO24770.1 - 0.055 13.4 1.8 0.12 12.3 1.8 1.5 1 0 0 1 1 1 0 Syndecan domain RIO1 PF01163.22 KOO24770.1 - 0.09 12.4 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Wzy_C PF04932.15 KOO24770.1 - 0.11 12.1 0.1 0.38 10.4 0.1 1.9 2 0 0 2 2 2 0 O-Antigen ligase DUF2755 PF10954.8 KOO24770.1 - 0.13 12.2 0.8 0.26 11.2 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2755) MASE3 PF17159.4 KOO24770.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Membrane-associated sensor domain EphA2_TM PF14575.6 KOO24770.1 - 0.19 12.7 0.1 0.4 11.6 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MtrF PF09472.10 KOO24770.1 - 0.28 10.6 5.4 0.59 9.6 5.4 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Glycophorin_A PF01102.18 KOO24770.1 - 0.32 11.3 2.1 0.6 10.4 1.3 1.8 1 1 0 1 1 1 0 Glycophorin A CRC_subunit PF08624.10 KOO24771.1 - 0.0016 18.9 0.0 0.025 15.0 0.0 2.1 2 0 0 2 2 2 1 Chromatin remodelling complex Rsc7/Swp82 subunit Peptidase_S9_N PF02897.15 KOO24772.1 - 0.0081 15.0 0.1 0.0092 14.8 0.1 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain FKBP_N PF01346.18 KOO24772.1 - 0.67 11.0 4.3 0.94 10.5 4.3 1.3 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Glyco_tranf_2_4 PF13704.6 KOO24773.1 - 8e-11 42.3 0.1 1e-09 38.8 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 DHC_N1 PF08385.12 KOO24774.1 - 1.9e-143 479.1 0.0 4.5e-143 477.9 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 KOO24774.1 - 1.7e-132 441.4 0.0 4.1e-131 436.8 0.0 2.5 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO24774.1 - 1.3e-95 320.8 3.4 1.3e-95 320.8 3.4 3.1 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO24774.1 - 1.9e-95 319.1 0.0 4.5e-95 317.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KOO24774.1 - 2e-81 273.6 0.0 8.5e-80 268.2 0.0 2.6 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain MT PF12777.7 KOO24774.1 - 3.1e-79 266.5 5.3 5.9e-79 265.6 5.3 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.7 KOO24774.1 - 4.2e-62 209.1 0.1 3.1e-61 206.3 0.0 2.5 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 KOO24774.1 - 1e-60 204.4 0.2 1.9e-58 197.0 0.0 3.0 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KOO24774.1 - 2.2e-44 151.2 0.0 4.7e-44 150.1 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO24774.1 - 4e-32 110.8 0.0 1.6e-31 108.9 0.0 2.1 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 KOO24774.1 - 4.7e-26 90.9 0.2 2.6e-25 88.5 0.1 2.4 2 0 0 2 2 2 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 KOO24774.1 - 4e-22 78.7 0.0 1.3e-21 77.0 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO24774.1 - 8.6e-17 61.4 0.0 5.4e-06 26.5 0.0 5.4 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.29 KOO24774.1 - 0.011 16.2 0.0 10 6.6 0.0 3.7 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Fur_reg_FbpB PF13040.6 KOO24774.1 - 0.68 9.5 3.0 2.9 7.5 0.1 2.7 2 0 0 2 2 2 0 Fur-regulated basic protein B PPR_1 PF12854.7 KOO24774.1 - 0.86 9.4 4.5 6.4 6.6 1.0 3.1 2 0 0 2 2 2 0 PPR repeat PAN_1 PF00024.26 KOO24775.1 - 0.0017 18.3 1.9 0.0038 17.2 1.9 1.5 1 0 0 1 1 1 1 PAN domain OmpA PF00691.20 KOO24777.1 - 0.096 13.1 0.0 0.27 11.6 0.0 1.7 1 0 0 1 1 1 0 OmpA family PfkB PF00294.24 KOO24778.1 - 2.6e-56 191.2 1.5 2.6e-56 191.2 1.5 1.5 2 0 0 2 2 2 1 pfkB family carbohydrate kinase Rib_5-P_isom_A PF06026.14 KOO24778.1 - 7.4e-45 152.7 0.0 1.1e-44 152.1 0.0 1.3 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Phos_pyr_kin PF08543.12 KOO24778.1 - 4e-07 29.7 0.0 7.5e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DeoRC PF00455.22 KOO24778.1 - 0.034 14.1 0.1 8.5 6.3 0.0 2.7 2 0 0 2 2 2 0 DeoR C terminal sensor domain MoCF_biosynth PF00994.24 KOO24778.1 - 0.066 12.9 0.2 0.22 11.2 0.1 1.9 2 0 0 2 2 2 0 Probable molybdopterin binding domain DUF4203 PF13886.6 KOO24779.1 - 0.0014 18.3 6.8 0.0019 17.9 6.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Phage_holin_3_6 PF07332.11 KOO24779.1 - 0.076 13.1 5.1 0.21 11.6 5.1 1.8 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III SLATT_fungal PF18142.1 KOO24779.1 - 2.5 8.1 4.9 4 7.4 4.9 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Glyco_hydro_20 PF00728.22 KOO24780.1 - 3.7e-59 200.9 0.0 4.9e-59 200.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 KOO24780.1 - 8.1e-06 26.5 0.0 1.9e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like GspL_C PF12693.7 KOO24780.1 - 0.031 14.1 3.8 0.26 11.1 2.0 2.3 2 0 0 2 2 2 0 GspL periplasmic domain Phenyl_P_gamma PF09662.10 KOO24781.1 - 1.1 9.5 3.7 28 5.0 0.1 3.6 3 1 0 4 4 4 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) Pro-kuma_activ PF09286.11 KOO24782.1 - 1.5e-19 70.7 0.0 2.4e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 KOO24782.1 - 0.00013 21.4 0.1 0.00019 20.8 0.1 1.3 1 0 0 1 1 1 1 Subtilase family KIAA1430 PF13879.6 KOO24783.1 - 9.3e-06 26.3 8.0 0.0017 19.1 2.2 2.8 1 1 1 2 2 2 2 KIAA1430 homologue NYD-SP28_assoc PF14775.6 KOO24783.1 - 0.041 14.0 4.4 11 6.2 0.2 3.4 3 0 0 3 3 3 0 Sperm tail C-terminal domain DUF4763 PF15960.5 KOO24783.1 - 0.045 13.1 1.0 0.069 12.4 1.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) SlyX PF04102.12 KOO24783.1 - 0.27 11.9 4.5 3.3 8.4 0.6 2.8 1 1 1 2 2 2 0 SlyX YgaB PF14182.6 KOO24783.1 - 0.41 11.1 5.7 0.82 10.1 0.7 2.7 1 1 1 2 2 2 0 YgaB-like protein Borrelia_orfA PF02414.15 KOO24783.1 - 4.3 6.9 7.9 0.61 9.7 2.9 1.8 2 0 0 2 2 2 0 Borrelia ORF-A DASH_Spc19 PF08287.11 KOO24783.1 - 4.6 7.1 14.8 0.19 11.6 6.8 2.2 1 1 1 2 2 2 0 Spc19 YabA PF06156.13 KOO24783.1 - 5.4 7.7 8.2 9.2 7.0 0.4 3.2 1 1 3 4 4 4 0 Initiation control protein YabA Fez1 PF06818.15 KOO24783.1 - 5.6 7.4 15.3 4.3 7.7 13.7 1.7 1 1 0 1 1 1 0 Fez1 Ribosomal_L17 PF01196.19 KOO24785.1 - 3.8e-30 104.6 0.0 5.1e-30 104.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L17 DnaJ PF00226.31 KOO24787.1 - 5e-07 29.8 0.0 7.7e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain GAS PF13851.6 KOO24788.1 - 0.0082 15.5 2.3 0.01 15.2 2.3 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Ino80_Iec3 PF14612.6 KOO24788.1 - 0.039 14.6 2.3 0.045 14.4 2.3 1.1 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling Fez1 PF06818.15 KOO24788.1 - 0.095 13.1 6.2 0.11 12.9 6.2 1.1 1 0 0 1 1 1 0 Fez1 MAD PF05557.13 KOO24788.1 - 9.6 4.4 10.5 11 4.3 10.5 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Aldo_ket_red PF00248.21 KOO24790.1 - 1.2e-42 146.2 0.0 2.5e-42 145.1 0.0 1.5 1 0 0 1 1 1 1 Aldo/keto reductase family Val_tRNA-synt_C PF10458.9 KOO24790.1 - 0.049 13.9 2.1 0.12 12.7 2.1 1.7 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm Tmemb_cc2 PF10267.9 KOO24790.1 - 0.099 11.8 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF5517 PF17639.2 KOO24790.1 - 1.5 9.1 4.7 2.9 8.2 4.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5517) Strep_SA_rep PF06696.11 KOO24790.1 - 2.9 8.0 11.1 0.91 9.6 7.1 2.3 2 0 0 2 2 2 0 Streptococcal surface antigen repeat TPT PF03151.16 KOO24791.1 - 1.1e-19 70.9 1.3 1.2e-19 70.7 1.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO24791.1 - 0.0018 18.4 8.4 0.0024 18.0 8.4 1.2 1 0 0 1 1 1 1 EamA-like transporter family Hydrolase_3 PF08282.12 KOO24793.1 - 1e-19 71.3 0.1 1.4e-19 70.9 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Tic22 PF04278.12 KOO24793.1 - 0.00011 21.7 0.0 0.00031 20.2 0.0 1.8 1 1 0 1 1 1 1 Tic22-like family Hydrolase PF00702.26 KOO24793.1 - 0.0013 19.0 0.0 0.0029 17.9 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4232 PF14016.6 KOO24793.1 - 0.087 13.0 2.2 0.14 12.3 1.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4232) S6PP PF05116.13 KOO24793.1 - 0.16 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase SAP PF02037.27 KOO24794.1 - 8.7e-10 38.1 0.8 1.5e-09 37.4 0.8 1.4 1 0 0 1 1 1 1 SAP domain SURF2 PF05477.11 KOO24794.1 - 1.4e-09 38.0 0.0 2.3e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) Sigma70_r3 PF04539.16 KOO24795.1 - 0.055 13.6 0.5 0.24 11.5 0.1 2.1 2 0 0 2 2 2 0 Sigma-70 region 3 ArsD PF06953.11 KOO24795.1 - 0.15 12.4 0.2 2 8.8 0.1 2.2 1 1 1 2 2 2 0 Arsenical resistance operon trans-acting repressor ArsD HCV_NS4a PF01006.20 KOO24795.1 - 2 8.3 4.6 4.3 7.2 4.6 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4a CorA PF01544.18 KOO24796.1 - 6e-07 29.1 3.5 7.5e-07 28.8 3.5 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein AA_permease_2 PF13520.6 KOO24797.1 - 2.1e-32 112.5 26.3 2.6e-32 112.2 26.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOO24797.1 - 4.2e-11 42.1 25.7 3.2e-10 39.2 25.7 2.3 1 1 0 1 1 1 1 Amino acid permease EF-hand_5 PF13202.6 KOO24798.1 - 1.1e-13 50.0 5.4 4.7e-07 29.0 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO24798.1 - 7.2e-12 44.0 9.4 6.1e-06 25.4 1.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO24798.1 - 6.7e-11 41.2 7.2 1.4e-05 24.7 0.6 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO24798.1 - 1.3e-09 38.3 5.1 3.8e-09 36.9 5.0 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO24798.1 - 7.7e-06 25.7 7.4 0.023 14.5 0.8 2.5 2 0 0 2 2 2 2 EF-hand domain pair KIAA1430 PF13879.6 KOO24798.1 - 0.0004 21.1 26.5 0.23 12.2 0.4 4.2 3 1 0 3 3 3 2 KIAA1430 homologue EF-hand_4 PF12763.7 KOO24798.1 - 0.0073 16.2 3.8 1.9 8.5 0.7 2.7 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand CorA PF01544.18 KOO24798.1 - 1.6 8.0 9.9 3.3 7.0 9.9 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein TMCO5 PF14992.6 KOO24799.1 - 0.21 11.2 0.3 0.34 10.4 0.3 1.2 1 0 0 1 1 1 0 TMCO5 family DUF4771 PF15995.5 KOO24799.1 - 0.61 10.3 5.3 0.9 9.8 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4771) H2O2_YaaD PF03883.14 KOO24801.1 - 1.2e-52 178.7 0.0 1.5e-52 178.5 0.0 1.1 1 0 0 1 1 1 1 Peroxide stress protein YaaA DUF4413 PF14372.6 KOO24801.1 - 0.091 13.1 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) PGI PF00342.19 KOO24802.1 - 2.9e-238 791.3 0.0 3.7e-238 791.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoglucose isomerase EF-hand_1 PF00036.32 KOO24802.1 - 2.6e-21 73.5 6.5 4.5e-05 22.7 0.3 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO24802.1 - 2.2e-20 70.8 5.3 1.3e-05 24.7 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO24802.1 - 1e-19 70.8 1.5 9.8e-09 35.5 0.0 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO24802.1 - 1.7e-14 53.4 5.3 6.3e-06 25.9 0.3 4.8 3 1 1 4 4 4 3 EF-hand domain pair Ras PF00071.22 KOO24802.1 - 3.5e-11 43.0 0.0 7.3e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Ras family EF-hand_5 PF13202.6 KOO24802.1 - 6.2e-10 38.1 9.2 0.0034 16.8 0.2 4.4 4 0 0 4 4 4 3 EF hand Roc PF08477.13 KOO24802.1 - 3.7e-05 23.9 0.0 7.8e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_10 PF14788.6 KOO24802.1 - 0.0001 22.1 0.2 15 5.5 0.0 4.4 4 0 0 4 4 4 0 EF hand EF-hand_4 PF12763.7 KOO24802.1 - 0.0034 17.3 1.9 0.93 9.5 0.1 4.1 2 2 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand Arf PF00025.21 KOO24802.1 - 0.0087 15.5 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KOO24802.1 - 0.015 14.7 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 KOO24802.1 - 0.17 11.3 0.1 1.4 8.2 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein RRM_1 PF00076.22 KOO24803.1 - 5.3e-56 186.3 0.0 9.6e-22 76.6 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOO24803.1 - 0.003 17.2 0.0 0.24 11.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KOO24803.1 - 0.0091 16.1 0.3 0.21 11.7 0.0 3.0 4 0 0 4 4 4 1 Limkain b1 PHM7_cyt PF14703.6 KOO24803.1 - 0.019 15.2 0.0 2.5 8.3 0.0 3.3 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter RRM_occluded PF16842.5 KOO24803.1 - 0.044 13.6 0.0 14 5.6 0.0 3.8 4 0 0 4 4 4 0 Occluded RNA-recognition motif DbpA PF03880.15 KOO24803.1 - 0.085 12.9 0.0 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain RRM_7 PF16367.5 KOO24803.1 - 0.16 12.1 0.0 2.9 8.1 0.0 2.8 3 0 0 3 3 3 0 RNA recognition motif PP2C PF00481.21 KOO24804.1 - 0.031 13.9 0.4 0.047 13.3 0.4 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C SapB_1 PF05184.15 KOO24804.1 - 0.13 12.3 1.3 0.35 10.9 0.0 2.5 3 0 0 3 3 3 0 Saposin-like type B, region 1 Mito_carr PF00153.27 KOO24805.1 - 3.7e-38 129.3 0.1 1.5e-25 88.9 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein MFS_1 PF07690.16 KOO24806.1 - 1.1e-32 113.4 45.8 2e-25 89.5 25.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily SelK_SelG PF10961.8 KOO24806.1 - 0.19 12.3 0.5 0.96 10.1 0.3 2.2 3 0 0 3 3 3 0 Selenoprotein SelK_SelG DUF3431 PF11913.8 KOO24810.1 - 8.4e-25 87.8 0.2 1.7e-20 73.8 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3431) FadR_C PF07840.12 KOO24811.1 - 0.32 10.9 10.1 4.6 7.1 0.4 3.6 3 0 0 3 3 3 0 FadR C-terminal domain Dynein_light PF01221.18 KOO24811.1 - 1.4 9.3 10.9 26 5.2 0.3 3.8 3 0 0 3 3 3 0 Dynein light chain type 1 RcbX PF02341.15 KOO24811.1 - 2.2 8.6 6.0 26 5.1 0.2 3.6 4 0 0 4 4 4 0 RbcX protein DUF1677 PF07911.13 KOO24811.1 - 2.9 8.3 9.7 24 5.4 0.7 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1677) DHHC PF01529.20 KOO24812.1 - 1.1e-28 99.9 1.0 4.3e-28 98.1 0.8 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase HMG_box PF00505.19 KOO24813.1 - 1.9e-21 76.3 3.3 1.9e-21 76.3 3.3 3.3 3 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO24813.1 - 1.2e-14 54.6 2.0 1.2e-14 54.6 2.0 3.3 2 1 0 2 2 2 1 HMG-box domain Med26 PF08711.11 KOO24813.1 - 1e-09 38.3 0.0 2.9e-09 36.8 0.0 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain PWWP PF00855.17 KOO24813.1 - 1.2e-09 38.4 0.1 1.2e-09 38.4 0.1 3.9 2 1 0 2 2 2 1 PWWP domain DEK_C PF08766.11 KOO24813.1 - 4.2e-08 33.0 0.1 1.3e-07 31.4 0.0 2.0 2 0 0 2 2 2 1 DEK C terminal domain LOR PF04525.12 KOO24814.1 - 0.014 15.0 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 LURP-one-related Glutaredoxin PF00462.24 KOO24815.1 - 2.4e-21 75.7 0.1 3.5e-21 75.2 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_9 PF14595.6 KOO24815.1 - 0.0024 17.6 0.0 0.0027 17.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOO24815.1 - 0.0067 16.9 0.0 0.0082 16.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain GST_N_2 PF13409.6 KOO24815.1 - 0.034 14.5 0.0 0.22 11.8 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 KOO24815.1 - 0.063 13.7 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 KOO24815.1 - 0.087 13.3 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DSBA PF01323.20 KOO24815.1 - 0.089 12.6 2.5 0.95 9.2 0.2 2.2 1 1 0 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 KOO24815.1 - 0.091 12.8 0.1 0.21 11.7 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin domain Thioredoxin_4 PF13462.6 KOO24815.1 - 0.23 11.6 1.9 2.1 8.4 0.6 2.3 1 1 1 2 2 2 0 Thioredoxin Radical_SAM PF04055.21 KOO24816.1 - 2.9e-10 40.8 0.0 6.1e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily LIAS_N PF16881.5 KOO24816.1 - 0.089 13.2 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of lipoyl synthase of Radical_SAM family Filamin PF00630.19 KOO24817.1 - 2.7e-43 147.0 0.0 3.1e-12 47.2 0.0 7.0 5 2 0 5 5 5 5 Filamin/ABP280 repeat LRR_6 PF13516.6 KOO24817.1 - 4.9e-29 97.9 56.9 0.003 17.5 1.2 13.1 13 0 0 13 13 13 10 Leucine Rich repeat Invasin_D3 PF09134.10 KOO24817.1 - 4.6e-09 36.5 0.0 6.7e-05 23.1 0.0 4.2 3 0 0 3 3 3 1 Invasin, domain 3 LRR_4 PF12799.7 KOO24817.1 - 2.2e-07 31.1 15.5 2.5 8.6 0.2 7.0 8 0 0 8 8 7 4 Leucine Rich repeats (2 copies) EF-hand_7 PF13499.6 KOO24817.1 - 8.5e-05 22.9 0.0 0.0019 18.6 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair C2 PF00168.30 KOO24817.1 - 0.00019 21.7 0.0 0.00043 20.5 0.0 1.6 1 0 0 1 1 1 1 C2 domain NACHT PF05729.12 KOO24817.1 - 0.00039 20.4 0.1 0.0016 18.4 0.1 2.0 2 0 0 2 2 2 1 NACHT domain DUF4030 PF13222.6 KOO24817.1 - 0.0024 18.0 0.0 28 4.8 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF4030) NDK PF00334.19 KOO24817.1 - 0.0036 17.3 0.0 0.11 12.6 0.0 2.5 2 0 0 2 2 2 1 Nucleoside diphosphate kinase KOW PF00467.29 KOO24817.1 - 0.078 13.0 0.6 0.24 11.4 0.6 1.9 1 0 0 1 1 1 0 KOW motif EF-hand_6 PF13405.6 KOO24817.1 - 0.12 12.3 0.1 5.6 7.2 0.0 3.5 2 1 0 2 2 2 0 EF-hand domain Glyco_hydro2_C5 PF18565.1 KOO24817.1 - 0.13 12.2 0.5 33 4.4 0.0 3.2 3 0 0 3 3 3 0 Glycoside hydrolase family 2 C-terminal domain 5 TFIIIC_delta PF12657.7 KOO24817.1 - 0.64 9.9 2.8 0.5 10.3 0.1 2.2 3 0 0 3 3 3 0 Transcription factor IIIC subunit delta N-term Miff PF05644.11 KOO24817.1 - 3.8 7.0 9.2 8.9 5.8 9.2 1.6 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff adh_short PF00106.25 KOO24818.1 - 2.7e-13 49.8 0.0 3.6e-08 33.1 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO24818.1 - 3.1e-10 40.0 0.0 7.2e-05 22.5 0.0 2.5 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Pox_Ag35 PF03286.14 KOO24818.1 - 0.13 12.0 1.1 0.23 11.2 1.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PARP PF00644.20 KOO24819.1 - 1.4e-59 200.9 0.0 2.4e-59 200.2 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 KOO24819.1 - 2e-37 128.3 0.0 3.3e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 KOO24819.1 - 1.6e-18 66.5 0.5 4e-18 65.2 0.3 1.8 2 0 0 2 2 2 1 WGR domain SAP PF02037.27 KOO24819.1 - 1.8e-09 37.1 0.0 4.8e-09 35.8 0.0 1.8 1 0 0 1 1 1 1 SAP domain WWE PF02825.20 KOO24819.1 - 7.1e-06 26.5 0.0 1.6e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 WWE domain DUF1992 PF09350.10 KOO24820.1 - 2.1e-21 75.9 2.2 6.7e-21 74.2 0.2 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF1992) DUF5423 PF17461.2 KOO24820.1 - 0.075 11.9 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Cep57_CLD_2 PF14197.6 KOO24820.1 - 7.1 6.8 12.1 0.35 11.0 1.7 2.8 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Alpha-2-MRAP_N PF06400.11 KOO24821.1 - 0.032 14.2 0.4 0.059 13.4 0.4 1.4 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, N-terminal domain DUF218 PF02698.17 KOO24821.1 - 0.082 12.9 1.4 2.5 8.1 0.9 2.5 1 1 2 3 3 3 0 DUF218 domain DUF4387 PF14330.6 KOO24821.1 - 0.12 13.0 0.1 0.28 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4387) Thioredoxin PF00085.20 KOO24822.1 - 0.0031 17.5 0.1 0.0073 16.3 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin RNA_ligase PF09414.10 KOO24822.1 - 0.099 12.9 0.0 0.11 12.8 0.0 1.1 1 0 0 1 1 1 0 RNA ligase KxDL PF10241.9 KOO24824.1 - 1.9 8.8 8.7 0.29 11.4 1.8 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein zf-C3HC4_3 PF13920.6 KOO24825.1 - 3.3e-09 36.5 10.9 5.1e-09 35.9 10.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PDZ_6 PF17820.1 KOO24825.1 - 2.2e-05 24.2 0.0 4.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain zf-RING_2 PF13639.6 KOO24825.1 - 0.00047 20.4 9.9 0.00077 19.8 9.9 1.3 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KOO24825.1 - 0.0012 18.6 8.5 0.0029 17.4 8.5 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 PDZ PF00595.24 KOO24825.1 - 0.018 15.4 0.0 0.043 14.2 0.0 1.6 1 0 0 1 1 1 0 PDZ domain zf-RING_5 PF14634.6 KOO24825.1 - 0.15 12.1 9.8 0.29 11.1 9.8 1.5 1 1 0 1 1 1 0 zinc-RING finger domain zf-SNAP50_C PF12251.8 KOO24825.1 - 7.5 6.2 7.2 6.7 6.3 4.0 1.9 1 1 1 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal NT-C2 PF10358.9 KOO24826.1 - 1.6e-10 40.9 0.0 2.1e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins LSM_int_assoc PF16605.5 KOO24826.1 - 0.025 14.7 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 LSM-interacting associated unstructured Cnd2 PF05786.14 KOO24827.1 - 1.1e-35 123.6 0.1 3.1e-19 69.2 2.6 4.2 3 1 0 3 3 3 3 Condensin complex subunit 2 Trypan_PARP PF05887.11 KOO24827.1 - 0.0025 17.8 25.3 0.0025 17.8 25.3 2.3 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Acyltransferase PF01553.21 KOO24828.1 - 2.7e-18 65.9 0.0 5.4e-09 35.8 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase DUF550 PF04447.12 KOO24829.1 - 0.045 13.9 3.3 11 6.1 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF550) Scm3 PF10384.9 KOO24829.1 - 0.22 11.3 1.6 0.81 9.5 0.2 2.4 2 0 0 2 2 2 0 Centromere protein Scm3 CCDC-167 PF15188.6 KOO24829.1 - 4.1 7.8 10.5 4.6 7.6 1.4 3.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF4404 PF14357.6 KOO24829.1 - 7.9 7.2 11.9 43 4.8 0.2 4.3 4 2 0 4 4 4 0 Domain of unknown function (DUF4404) DUF3638 PF12340.8 KOO24830.1 - 0.0014 18.0 0.1 0.0028 17.0 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3552 PF12072.8 KOO24831.1 - 0.003 17.0 4.3 0.0034 16.8 4.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) DUF3618 PF12277.8 KOO24831.1 - 0.008 16.4 1.3 0.016 15.4 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3618) Spc7 PF08317.11 KOO24831.1 - 0.013 14.4 7.4 0.014 14.3 7.4 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Prp19 PF08606.11 KOO24831.1 - 0.038 14.0 0.6 0.087 12.8 0.6 1.5 1 0 0 1 1 1 0 Prp19/Pso4-like BST2 PF16716.5 KOO24831.1 - 0.17 12.5 5.4 0.21 12.2 5.4 1.1 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 PVL_ORF50 PF07768.11 KOO24831.1 - 0.2 12.0 2.4 0.23 11.8 2.4 1.1 1 0 0 1 1 1 0 PVL ORF-50-like family TMPIT PF07851.13 KOO24831.1 - 0.35 10.1 0.8 0.38 10.0 0.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein UPF0449 PF15136.6 KOO24831.1 - 3 8.3 6.4 2.3 8.7 1.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Ank_5 PF13857.6 KOO24832.1 - 5.1e-21 74.5 3.3 3.2e-06 27.3 0.0 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO24832.1 - 6.7e-21 74.7 0.0 1.9e-10 41.2 0.0 3.6 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO24832.1 - 1.2e-20 73.6 2.0 0.00049 20.6 0.1 6.3 2 2 5 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 KOO24832.1 - 1.1e-16 60.4 6.1 0.00057 20.2 0.0 6.7 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.6 KOO24832.1 - 1.1e-14 53.1 2.0 0.42 11.3 0.0 7.8 8 1 0 8 8 8 5 Ankyrin repeat Methyltransf_21 PF05050.12 KOO24834.1 - 2.9e-07 30.7 0.0 4.5e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain Phospholip_B PF04916.13 KOO24835.1 - 4.3e-151 504.1 0.5 5.7e-151 503.7 0.5 1.0 1 0 0 1 1 1 1 Phospholipase B Pkinase_Tyr PF07714.17 KOO24836.1 - 1.1e-17 64.2 0.0 1.1e-17 64.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 KOO24836.1 - 3e-16 59.6 1.0 5.7e-16 58.7 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Borrelia_P83 PF05262.11 KOO24836.1 - 0.014 13.9 4.1 0.047 12.2 5.1 1.4 2 0 0 2 2 2 0 Borrelia P83/100 protein SRP-alpha_N PF04086.13 KOO24836.1 - 0.13 12.2 9.4 0.18 11.7 9.4 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Kei1 PF08552.11 KOO24836.1 - 1.9 8.3 7.9 3.8 7.4 7.9 1.5 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 NARP1 PF12569.8 KOO24836.1 - 2 7.3 17.6 3.7 6.4 17.6 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Coilin_N PF15862.5 KOO24836.1 - 2.6 7.8 8.0 16 5.3 8.0 2.0 1 1 0 1 1 1 0 Coilin N-terminus IHABP4_N PF16174.5 KOO24836.1 - 6 7.4 13.2 10 6.7 13.2 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal zf-RING_2 PF13639.6 KOO24837.1 - 1.5e-11 44.4 4.9 2.4e-11 43.8 4.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO24837.1 - 8e-10 38.4 4.3 1.3e-09 37.8 4.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO24837.1 - 6.9e-08 32.2 3.7 1.1e-07 31.6 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KOO24837.1 - 2.8e-06 26.8 2.2 5.6e-06 25.9 2.2 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 KOO24837.1 - 2.9e-06 26.9 1.7 5e-06 26.2 1.7 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 KOO24837.1 - 8.9e-06 25.9 8.3 4.9e-05 23.5 8.3 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 KOO24837.1 - 2e-05 24.3 3.2 3.1e-05 23.7 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO24837.1 - 0.0001 22.2 3.2 0.00017 21.5 3.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO24837.1 - 0.0006 19.8 5.8 0.0012 18.8 5.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger DUF2586 PF10758.9 KOO24837.1 - 0.0067 15.7 0.9 0.0094 15.2 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2586) AAA_13 PF13166.6 KOO24837.1 - 0.013 14.2 2.5 0.017 13.8 2.5 1.1 1 0 0 1 1 1 0 AAA domain zf-ANAPC11 PF12861.7 KOO24837.1 - 0.014 15.5 3.2 0.032 14.3 3.2 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.11 KOO24837.1 - 0.028 14.7 3.2 0.048 14.0 3.2 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 KOO24837.1 - 0.056 13.2 2.9 0.14 12.0 2.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 KOO24837.1 - 0.08 13.1 4.6 0.14 12.3 4.6 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FGase PF05013.12 KOO24837.1 - 0.19 11.9 2.7 0.29 11.3 2.7 1.3 1 0 0 1 1 1 0 N-formylglutamate amidohydrolase FANCL_C PF11793.8 KOO24837.1 - 0.24 11.6 4.3 0.94 9.7 4.3 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Zf_RING PF16744.5 KOO24837.1 - 0.55 10.4 2.7 0.85 9.8 1.5 2.0 2 0 0 2 2 2 0 KIAA1045 RING finger RINGv PF12906.7 KOO24837.1 - 0.85 9.8 4.4 3 8.0 4.2 2.0 1 1 0 1 1 1 0 RING-variant domain zf-UDP PF14569.6 KOO24837.1 - 1.3 9.2 4.5 6 7.1 4.5 2.0 1 1 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 KOO24837.1 - 3.4 7.6 5.8 15 5.5 5.9 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3H2C3 PF17122.5 KOO24837.1 - 8 6.6 6.7 22 5.2 6.7 1.8 1 1 0 1 1 1 0 Zinc-finger AAA PF00004.29 KOO24839.1 - 7.7e-39 133.1 0.0 1.2e-38 132.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO24839.1 - 2.7e-13 49.5 0.4 6.6e-13 48.2 0.4 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KOO24839.1 - 6.3e-06 26.7 0.8 6.4e-05 23.4 0.6 2.3 1 1 0 1 1 1 1 AAA ATPase domain Shugoshin_C PF07557.11 KOO24839.1 - 2.3e-05 24.1 0.1 6.9e-05 22.6 0.1 1.9 1 0 0 1 1 1 1 Shugoshin C terminus IstB_IS21 PF01695.17 KOO24839.1 - 6.3e-05 22.8 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 KOO24839.1 - 7.1e-05 23.0 0.0 0.00015 21.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOO24839.1 - 0.00091 19.5 0.3 0.025 14.8 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO24839.1 - 0.0022 17.8 0.0 0.0051 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO24839.1 - 0.0032 17.5 0.0 0.013 15.5 0.0 2.1 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KOO24839.1 - 0.0063 16.7 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO24839.1 - 0.014 15.9 0.0 0.029 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 KOO24839.1 - 0.015 15.1 0.0 0.089 12.5 0.0 2.0 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activ_2 PF14532.6 KOO24839.1 - 0.023 14.8 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 KOO24839.1 - 0.023 14.9 0.1 0.053 13.8 0.0 1.7 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 KOO24839.1 - 0.024 14.0 0.1 0.042 13.2 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 KOO24839.1 - 0.026 13.8 0.0 0.037 13.2 0.0 1.1 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_25 PF13481.6 KOO24839.1 - 0.029 14.0 0.0 0.061 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO24839.1 - 0.034 13.4 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 KOO24839.1 - 0.042 13.6 0.0 0.078 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 KOO24839.1 - 0.047 13.7 0.0 0.071 13.1 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 KOO24839.1 - 0.082 13.3 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 KOO24839.1 - 0.095 12.4 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 KOO24839.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 KOO24839.1 - 0.16 11.0 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 zf-RING_2 PF13639.6 KOO24840.1 - 1.5e-11 44.4 4.9 2.4e-11 43.8 4.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO24840.1 - 8e-10 38.4 4.3 1.3e-09 37.8 4.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO24840.1 - 6.9e-08 32.2 3.7 1.1e-07 31.6 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KOO24840.1 - 2.8e-06 26.8 2.2 5.6e-06 25.9 2.2 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 KOO24840.1 - 2.9e-06 26.9 1.7 5e-06 26.2 1.7 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 KOO24840.1 - 8.9e-06 25.9 8.3 4.9e-05 23.5 8.3 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 KOO24840.1 - 2e-05 24.3 3.2 3.1e-05 23.7 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO24840.1 - 0.0001 22.2 3.2 0.00017 21.5 3.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO24840.1 - 0.0006 19.8 5.8 0.0012 18.8 5.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger DUF2586 PF10758.9 KOO24840.1 - 0.0067 15.7 0.9 0.0094 15.2 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2586) AAA_13 PF13166.6 KOO24840.1 - 0.013 14.2 2.5 0.017 13.8 2.5 1.1 1 0 0 1 1 1 0 AAA domain zf-ANAPC11 PF12861.7 KOO24840.1 - 0.014 15.5 3.2 0.032 14.3 3.2 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.11 KOO24840.1 - 0.028 14.7 3.2 0.048 14.0 3.2 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 KOO24840.1 - 0.056 13.2 2.9 0.14 12.0 2.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 KOO24840.1 - 0.08 13.1 4.6 0.14 12.3 4.6 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FGase PF05013.12 KOO24840.1 - 0.19 11.9 2.7 0.29 11.3 2.7 1.3 1 0 0 1 1 1 0 N-formylglutamate amidohydrolase FANCL_C PF11793.8 KOO24840.1 - 0.24 11.6 4.3 0.94 9.7 4.3 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Zf_RING PF16744.5 KOO24840.1 - 0.55 10.4 2.7 0.85 9.8 1.5 2.0 2 0 0 2 2 2 0 KIAA1045 RING finger RINGv PF12906.7 KOO24840.1 - 0.85 9.8 4.4 3 8.0 4.2 2.0 1 1 0 1 1 1 0 RING-variant domain zf-UDP PF14569.6 KOO24840.1 - 1.3 9.2 4.5 6 7.1 4.5 2.0 1 1 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 KOO24840.1 - 3.4 7.6 5.8 15 5.5 5.9 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3H2C3 PF17122.5 KOO24840.1 - 8 6.6 6.7 22 5.2 6.7 1.8 1 1 0 1 1 1 0 Zinc-finger p25-alpha PF05517.12 KOO24841.1 - 1.4e-05 25.3 22.7 0.044 13.9 3.8 6.9 7 0 0 7 7 7 2 p25-alpha EF-hand_8 PF13833.6 KOO24841.1 - 0.0078 16.0 9.6 0.63 9.9 0.1 6.5 7 0 0 7 7 7 2 EF-hand domain pair CH_2 PF06294.11 KOO24841.1 - 0.26 11.4 9.7 4.4 7.5 0.2 4.8 6 0 0 6 6 6 0 CH-like domain in sperm protein MCR_D PF02505.14 KOO24841.1 - 9.5 6.1 5.7 4.4 7.2 0.3 2.8 3 0 0 3 3 3 0 Methyl-coenzyme M reductase operon protein D AAA PF00004.29 KOO24842.1 - 9.2e-39 132.9 0.0 1.4e-38 132.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO24842.1 - 3.1e-13 49.3 0.4 7.6e-13 48.0 0.4 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KOO24842.1 - 6.7e-06 26.6 0.6 6.1e-05 23.5 0.5 2.3 1 1 0 1 1 1 1 AAA ATPase domain Shugoshin_C PF07557.11 KOO24842.1 - 2.4e-05 24.0 0.1 7.8e-05 22.4 0.1 2.0 1 0 0 1 1 1 1 Shugoshin C terminus IstB_IS21 PF01695.17 KOO24842.1 - 7.6e-05 22.5 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 KOO24842.1 - 8.6e-05 22.7 0.0 0.00019 21.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOO24842.1 - 0.0012 19.1 0.3 0.029 14.6 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO24842.1 - 0.0026 17.5 0.0 0.006 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO24842.1 - 0.004 17.1 0.0 0.015 15.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KOO24842.1 - 0.0071 16.5 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO24842.1 - 0.016 15.7 0.0 0.034 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 KOO24842.1 - 0.019 14.7 0.1 0.11 12.3 0.1 2.0 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activ_2 PF14532.6 KOO24842.1 - 0.026 14.7 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 KOO24842.1 - 0.026 14.7 0.0 0.061 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KOO24842.1 - 0.027 13.9 0.1 0.048 13.0 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 KOO24842.1 - 0.027 13.7 0.0 0.043 13.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_25 PF13481.6 KOO24842.1 - 0.034 13.7 0.0 0.071 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO24842.1 - 0.039 13.2 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 KOO24842.1 - 0.049 13.4 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 KOO24842.1 - 0.055 13.5 0.0 0.085 12.9 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 KOO24842.1 - 0.093 13.1 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 KOO24842.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 KOO24842.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 KOO24842.1 - 0.18 10.9 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Agenet PF05641.12 KOO24843.1 - 2e-15 57.0 8.2 1.6e-07 31.7 0.4 4.5 3 1 1 4 4 4 4 Agenet domain PP2C PF00481.21 KOO24844.1 - 4.1e-26 92.1 0.0 5.4e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO24844.1 - 3e-09 37.1 0.3 9.2e-08 32.2 0.3 2.2 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Glyco_trans_1_3 PF13528.6 KOO24845.1 - 2.8e-10 39.9 0.1 3.2e-08 33.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 1 GHMP_kinases_N PF00288.26 KOO24845.1 - 6.8e-10 39.0 1.1 3.1e-09 36.9 1.1 2.3 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KOO24845.1 - 1.2e-08 35.2 0.1 4.2e-08 33.4 0.1 2.0 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 KOO24845.1 - 3.8e-07 29.6 0.3 7.9e-06 25.3 0.0 3.1 3 0 0 3 3 3 1 Galactokinase galactose-binding signature Glyco_transf_4 PF13439.6 KOO24845.1 - 0.03 14.3 1.9 0.087 12.8 0.7 2.5 2 1 0 2 2 2 0 Glycosyltransferase Family 4 Rotamase PF00639.21 KOO24846.1 - 4e-16 59.8 0.0 5.5e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOO24846.1 - 1.4e-14 54.6 0.0 2.3e-14 53.9 0.0 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 KOO24846.1 - 0.034 15.0 0.0 0.045 14.6 0.0 1.2 1 0 0 1 1 1 0 PPIC-type PPIASE domain Cys_rich_FGFR PF00839.17 KOO24847.1 - 0.0016 18.6 5.8 0.0024 18.0 0.0 2.6 2 1 0 2 2 2 1 Cysteine rich repeat YkyA PF10368.9 KOO24847.1 - 0.86 9.3 10.1 1.2 8.8 10.1 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein IQ PF00612.27 KOO24848.1 - 4.6e-10 38.4 16.9 0.02 14.7 0.1 5.4 5 0 0 5 5 5 5 IQ calmodulin-binding motif HHV-5_US34A PF17087.5 KOO24848.1 - 0.24 11.6 0.7 0.67 10.1 0.7 1.7 1 0 0 1 1 1 0 Herpesvirus US34A protein family Gryzun PF07919.12 KOO24848.1 - 0.48 9.1 6.9 0.3 9.8 1.7 2.5 2 1 0 2 2 2 0 Gryzun, putative trafficking through Golgi FXR_C1 PF16096.5 KOO24848.1 - 0.52 10.5 5.8 0.19 11.9 0.7 2.6 1 1 2 3 3 3 0 Fragile X-related 1 protein C-terminal region 2 Tropomyosin PF00261.20 KOO24849.1 - 0.033 13.5 0.0 0.047 13.1 0.0 1.1 1 0 0 1 1 1 0 Tropomyosin Eclosion PF04736.12 KOO24849.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Eclosion hormone EF-hand_7 PF13499.6 KOO24850.1 - 6.8e-09 36.1 1.4 9.5e-06 26.0 0.5 1.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO24850.1 - 4.2e-08 32.3 1.0 8e-05 22.0 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO24850.1 - 1.6e-07 30.4 0.1 0.0014 18.0 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO24850.1 - 3.4e-07 29.7 0.2 0.0026 17.6 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO24850.1 - 3.4e-05 23.6 0.0 0.0055 16.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair T3RM_EcoP15I_C PF18273.1 KOO24850.1 - 0.05 13.9 0.0 0.065 13.6 0.0 1.2 1 0 0 1 1 1 0 Type III R-M EcoP15I C-terminal domain FA_desaturase PF00487.24 KOO24852.1 - 2.3e-29 103.0 16.2 4.7e-29 102.0 16.2 1.4 1 1 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 KOO24852.1 - 4.1e-17 61.4 0.2 7.3e-17 60.6 0.2 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Ank_2 PF12796.7 KOO24853.1 - 1.2e-63 211.7 13.7 6.2e-13 49.1 0.1 9.2 3 1 4 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO24853.1 - 1e-55 185.4 15.8 3.7e-08 33.7 0.1 12.3 7 2 7 15 15 15 13 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO24853.1 - 1.9e-47 158.7 24.3 7.6e-07 29.3 0.1 12.6 9 4 2 12 12 12 8 Ankyrin repeats (many copies) Ank PF00023.30 KOO24853.1 - 4.4e-40 134.4 35.9 0.00015 22.1 0.1 17.2 17 1 1 18 18 18 10 Ankyrin repeat Ank_3 PF13606.6 KOO24853.1 - 1.1e-39 129.8 19.6 2.7e-05 24.2 0.0 17.6 19 0 0 19 19 19 10 Ankyrin repeat FYVE PF01363.21 KOO24853.1 - 1.1e-13 51.1 14.9 2e-13 50.3 14.9 1.5 1 0 0 1 1 1 1 FYVE zinc finger BTB PF00651.31 KOO24853.1 - 0.015 15.6 0.0 0.034 14.4 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain zf-piccolo PF05715.13 KOO24853.1 - 2 8.6 12.4 4.8 7.4 12.4 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger DHHC PF01529.20 KOO24853.1 - 9.7 6.3 7.9 19 5.4 7.9 1.5 1 0 0 1 1 1 0 DHHC palmitoyltransferase VWA PF00092.28 KOO24855.1 - 0.0018 18.6 0.0 0.0028 17.9 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 KOO24855.1 - 0.11 11.9 0.0 0.26 10.7 0.0 1.6 1 1 1 2 2 2 0 VWA domain containing CoxE-like protein DUF5455 PF17537.2 KOO24856.1 - 1.8 9.0 7.4 0.63 10.5 2.6 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5455) NTP_transferase PF00483.23 KOO24857.1 - 3.8e-06 26.6 0.0 6.2e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase GHMP_kinases_C PF08544.13 KOO24857.1 - 9.6e-06 25.9 0.0 2.1e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 KOO24857.1 - 0.0001 22.4 0.0 0.00022 21.4 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain Spc7 PF08317.11 KOO24858.1 - 0.015 14.2 14.3 0.037 12.9 14.3 1.7 1 0 0 1 1 1 0 Spc7 kinetochore protein EF-hand_7 PF13499.6 KOO24858.1 - 0.019 15.4 0.0 0.059 13.8 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 KOO24858.1 - 0.022 14.3 0.0 0.42 10.3 0.0 2.6 2 0 0 2 2 2 0 EF hand GLYCAM-1 PF05242.11 KOO24858.1 - 0.13 12.4 2.9 0.32 11.1 2.9 1.6 1 0 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) rRNA_processing PF08524.11 KOO24858.1 - 0.3 11.1 5.8 0.41 10.7 4.9 1.6 1 1 0 1 1 1 0 rRNA processing CaM_bdg_C0 PF10562.9 KOO24858.1 - 1.1 9.3 5.8 2.3 8.3 0.0 4.0 4 0 0 4 4 4 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit Apolipoprotein PF01442.18 KOO24858.1 - 2.1 8.2 26.6 2 8.3 23.3 2.5 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain PPTA PF01239.22 KOO24859.1 - 4.7e-37 124.7 14.9 1.4e-09 37.4 0.0 6.1 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat PEMT PF04191.13 KOO24861.1 - 4.2e-09 36.8 0.4 8e-09 35.9 0.4 1.5 1 1 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.14 KOO24861.1 - 0.0001 22.6 0.2 0.00021 21.6 0.0 1.6 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF1295 PF06966.12 KOO24861.1 - 0.005 16.4 1.6 0.0075 15.8 1.6 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.17 KOO24861.1 - 0.02 13.7 0.1 0.023 13.5 0.1 1.2 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family DUF2237 PF09996.9 KOO24862.1 - 2e-17 63.3 1.3 4.7e-17 62.0 1.3 1.7 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2237) adh_short PF00106.25 KOO24864.1 - 3.2e-22 78.9 0.0 5.3e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO24864.1 - 2e-12 47.2 0.1 3.4e-12 46.4 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO24864.1 - 0.081 12.8 0.5 0.74 9.7 0.5 2.1 1 1 0 1 1 1 0 KR domain WD40 PF00400.32 KOO24865.1 - 6.5 7.8 7.0 30 5.7 0.0 4.9 6 0 0 6 6 6 0 WD domain, G-beta repeat UPF0669 PF17065.5 KOO24867.1 - 8.2e-05 22.4 0.0 0.00013 21.8 0.0 1.2 1 0 0 1 1 1 1 Putative cytokine, C6ORF120 tRNA-synt_1c PF00749.21 KOO24868.1 - 1.9e-80 270.1 0.0 2.4e-80 269.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Tropomyosin_1 PF12718.7 KOO24869.1 - 0.012 15.8 11.9 0.012 15.8 11.9 5.2 1 1 2 4 4 4 0 Tropomyosin like BRE1 PF08647.11 KOO24869.1 - 0.025 14.7 5.4 0.025 14.7 5.4 7.2 2 2 6 8 8 8 0 BRE1 E3 ubiquitin ligase V_ATPase_I PF01496.19 KOO24869.1 - 0.097 10.6 36.2 0.62 7.9 4.1 2.9 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family VPS9 PF02204.18 KOO24871.1 - 1.8e-21 76.3 0.0 3.1e-21 75.5 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain FBPase PF00316.20 KOO24872.1 - 9.5e-35 119.8 0.0 1.5e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain NUDIX PF00293.28 KOO24873.1 - 0.04 14.0 0.6 0.18 11.9 0.6 2.1 1 1 0 1 1 1 0 NUDIX domain SEP PF08059.13 KOO24874.1 - 1.1e-22 80.4 0.0 4.4e-22 78.4 0.0 2.1 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 KOO24874.1 - 1.3e-09 38.1 0.0 1.9e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 UBX domain ubiquitin PF00240.23 KOO24874.1 - 0.03 14.1 0.1 0.11 12.3 0.1 1.9 1 1 0 1 1 1 0 Ubiquitin family cwf21 PF08312.12 KOO24876.1 - 5e-15 55.4 5.2 5e-15 55.4 5.2 2.7 2 1 0 2 2 2 1 cwf21 domain PDZ_6 PF17820.1 KOO24876.1 - 1.2e-08 34.7 0.1 2.3e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO24876.1 - 0.00043 20.5 0.4 0.0018 18.6 0.4 2.1 1 1 1 2 2 2 1 PDZ domain PDZ PF00595.24 KOO24876.1 - 0.00086 19.6 0.1 0.0026 18.0 0.1 1.8 1 0 0 1 1 1 1 PDZ domain SAM_1 PF00536.30 KOO24877.1 - 1.5e-20 73.4 0.0 2.1e-10 40.9 0.0 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO24877.1 - 5.8e-19 68.0 0.0 2.8e-10 40.1 0.0 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KOO24877.1 - 3.9e-06 26.7 0.0 0.024 14.6 0.0 2.6 1 1 0 2 2 2 2 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 KOO24877.1 - 2.9e-05 23.8 0.0 0.26 11.1 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Pro-kuma_activ PF09286.11 KOO24877.1 - 0.11 12.8 0.1 6.9 7.0 0.0 2.2 1 1 1 2 2 2 0 Pro-kumamolisin, activation domain Rad10 PF03834.14 KOO24878.1 - 1.2e-33 115.5 0.0 2.4e-33 114.5 0.0 1.5 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Ank_2 PF12796.7 KOO24878.1 - 8.8e-32 109.6 16.2 5.5e-10 39.7 0.1 5.2 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO24878.1 - 1e-27 96.1 17.5 8.2e-06 26.3 0.1 8.1 7 2 1 8 8 7 6 Ankyrin repeats (many copies) Dev_Cell_Death PF10539.9 KOO24878.1 - 3.4e-17 62.5 0.0 7.5e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Development and cell death domain Ank_5 PF13857.6 KOO24878.1 - 6.3e-17 61.4 14.6 0.00014 22.1 0.0 6.9 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO24878.1 - 3.7e-14 51.4 10.1 0.12 13.0 0.0 9.7 10 0 0 10 10 10 3 Ankyrin repeat Ank PF00023.30 KOO24878.1 - 2e-13 50.1 16.1 0.021 15.2 0.1 8.9 8 0 0 8 8 8 3 Ankyrin repeat Trypsin_2 PF13365.6 KOO24878.1 - 1.1e-05 26.3 0.0 3.8e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 Trypsin-like peptidase domain HHH_2 PF12826.7 KOO24878.1 - 0.075 13.1 0.0 0.42 10.7 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif HHH_5 PF14520.6 KOO24878.1 - 0.13 12.9 1.9 0.44 11.2 0.0 3.0 3 0 0 3 3 2 0 Helix-hairpin-helix domain Csm1_N PF18504.1 KOO24878.1 - 0.33 11.3 11.6 0.52 10.7 5.1 2.8 2 0 0 2 2 2 0 Csm1 N-terminal domain PDZ_6 PF17820.1 KOO24879.1 - 2e-09 37.1 0.2 4e-09 36.2 0.2 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO24879.1 - 9.4e-08 32.3 0.0 1.8e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO24879.1 - 0.00015 22.0 0.0 0.00035 20.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain CRISPR_Cse2 PF09485.10 KOO24879.1 - 1.3 9.5 7.3 0.32 11.5 2.4 2.2 1 1 1 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Glyoxalase_6 PF18029.1 KOO24879.1 - 1.7 9.4 4.2 0.75 10.6 0.2 2.3 2 1 0 2 2 2 0 Glyoxalase-like domain DnaJ_CXXCXGXG PF00684.19 KOO24880.1 - 3.5e-05 24.1 14.8 0.00013 22.2 14.8 2.0 1 1 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KOO24880.1 - 0.0019 18.2 11.0 0.58 10.2 8.1 3.2 1 1 1 2 2 2 1 Tryptophan RNA-binding attenuator protein inhibitory protein zf-4CXXC_R1 PF10497.9 KOO24880.1 - 0.0053 17.0 1.1 0.0097 16.1 1.1 1.3 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 FpoO PF10621.9 KOO24880.1 - 0.021 15.1 1.7 0.033 14.5 1.7 1.3 1 0 0 1 1 1 0 F420H2 dehydrogenase subunit FpoO PyrI_C PF02748.15 KOO24880.1 - 0.19 11.6 0.1 0.19 11.6 0.1 2.1 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF1356 PF07092.12 KOO24880.1 - 0.33 10.2 6.4 0.53 9.5 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) Prim_Zn_Ribbon PF08273.12 KOO24880.1 - 0.41 11.0 13.2 2 8.7 0.3 2.9 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase HypA PF01155.19 KOO24880.1 - 1.9 8.5 6.5 28 4.8 6.7 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF5351 PF17302.2 KOO24880.1 - 5.1 7.4 18.6 12 6.2 0.7 4.2 3 1 0 3 3 3 0 Family of unknown function (DUF5351) TFIIF_alpha PF05793.12 KOO24881.1 - 5.9e-13 48.3 18.7 3.3e-12 45.8 18.7 1.8 1 1 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) EF-hand_1 PF00036.32 KOO24882.1 - 2.9e-15 54.6 0.1 1.6e-07 30.4 0.0 2.1 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO24882.1 - 8.7e-14 51.1 0.9 4.8e-10 39.1 0.2 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO24882.1 - 3.6e-12 45.2 0.1 8.5e-06 25.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO24882.1 - 2.4e-11 43.9 0.1 3.1e-11 43.6 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO24882.1 - 4.9e-10 38.4 0.0 0.0011 18.4 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 KOO24882.1 - 1.7e-05 24.6 0.3 0.00041 20.2 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 KOO24882.1 - 0.0013 18.6 0.0 0.33 10.9 0.0 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 KOO24882.1 - 0.0014 18.6 0.0 0.0021 18.1 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TerB SPARC_Ca_bdg PF10591.9 KOO24882.1 - 0.026 14.8 0.1 0.61 10.4 0.0 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO24882.1 - 0.16 12.2 0.0 1.3 9.3 0.0 2.0 2 0 0 2 2 2 0 Dockerin type I domain Amino_oxidase PF01593.24 KOO24883.1 - 4.4e-20 72.4 0.0 5.9e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO24883.1 - 5.4e-12 45.8 0.4 1.4e-11 44.4 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO24883.1 - 2.8e-07 30.0 1.7 6.3e-07 28.8 1.7 1.6 1 0 0 1 1 1 1 FAD binding domain SWIRM PF04433.17 KOO24883.1 - 7.4e-07 29.4 0.0 1.4e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 SWIRM domain HI0933_like PF03486.14 KOO24883.1 - 1.6e-06 27.1 0.4 2.2e-06 26.6 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 KOO24883.1 - 2e-06 27.5 0.3 2.6e-06 27.1 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOO24883.1 - 7.8e-06 25.3 0.3 1.2e-05 24.7 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO24883.1 - 1.7e-05 24.2 0.2 2.3e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 KOO24883.1 - 4.2e-05 22.9 3.0 6.5e-05 22.3 3.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 KOO24883.1 - 8.7e-05 22.3 1.2 0.00018 21.2 1.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase zf-C2H2_11 PF16622.5 KOO24883.1 - 0.0001 22.0 1.8 0.00022 20.9 1.8 1.5 1 0 0 1 1 1 1 zinc-finger C2H2-type Thi4 PF01946.17 KOO24883.1 - 0.00053 19.3 0.1 0.00096 18.5 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 KOO24883.1 - 0.0016 17.8 0.8 0.0026 17.1 0.8 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOO24883.1 - 0.0017 17.5 0.9 0.0024 17.0 0.9 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 KOO24883.1 - 0.002 18.6 0.7 0.0038 17.7 0.7 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase zf-C2H2_4 PF13894.6 KOO24883.1 - 0.017 15.9 1.7 0.029 15.2 0.3 2.3 2 0 0 2 2 1 0 C2H2-type zinc finger YjeF_N PF03853.15 KOO24883.1 - 0.019 14.9 0.6 0.043 13.7 0.6 1.5 1 0 0 1 1 1 0 YjeF-related protein N-terminus Lycopene_cycl PF05834.12 KOO24883.1 - 0.02 14.0 0.5 0.033 13.3 0.5 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein XdhC_C PF13478.6 KOO24883.1 - 0.039 14.5 0.0 0.1 13.1 0.0 1.8 1 0 0 1 1 1 0 XdhC Rossmann domain 2-Hacid_dh_C PF02826.19 KOO24883.1 - 0.06 12.7 0.2 0.12 11.7 0.2 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 KOO24883.1 - 0.11 12.8 0.1 0.3 11.4 0.1 1.8 1 0 0 1 1 1 0 TrkA-N domain Glu_dehyd_C PF16912.5 KOO24883.1 - 0.16 11.5 0.1 0.32 10.4 0.1 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus MCRA PF06100.11 KOO24883.1 - 0.2 10.4 0.1 0.27 10.0 0.1 1.1 1 0 0 1 1 1 0 MCRA family Shikimate_DH PF01488.20 KOO24883.1 - 0.23 11.5 0.5 0.42 10.7 0.5 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase zf-C2HC_2 PF13913.6 KOO24883.1 - 1.1 9.3 3.8 2.2 8.2 3.8 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type UCR_Fe-S_N PF10399.9 KOO24883.1 - 1.4 8.3 4.9 3.4 7.1 4.9 1.7 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Amino_oxidase PF01593.24 KOO24884.1 - 1.7e-49 169.4 0.2 2.1e-49 169.0 0.2 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase TMEM107 PF14995.6 KOO24885.1 - 2.3e-17 63.6 9.2 2.7e-17 63.4 9.2 1.0 1 0 0 1 1 1 1 Transmembrane protein Anoctamin PF04547.12 KOO24886.1 - 1.4e-95 320.8 4.8 1.8e-95 320.5 4.8 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Gly_transf_sug PF04488.15 KOO24886.1 - 4.6e-07 30.4 0.0 1.1e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Anoct_dimer PF16178.5 KOO24886.1 - 0.00019 21.3 0.0 0.0032 17.2 0.0 2.1 1 1 1 2 2 2 2 Dimerisation domain of Ca+-activated chloride-channel, anoctamin DUF4201 PF13870.6 KOO24887.1 - 2.7e-41 141.2 26.4 2.7e-41 141.2 26.4 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF4201) DUF1664 PF07889.12 KOO24887.1 - 0.012 15.6 0.8 0.012 15.6 0.8 3.6 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Emaravirus_P4 PF16505.5 KOO24887.1 - 0.26 10.3 5.2 0.23 10.4 3.7 1.5 1 1 0 1 1 1 0 P4 movement protein of Emaravirus, and the 30K superfamily COG5 PF10392.9 KOO24887.1 - 4.6 7.4 18.8 1.5 9.0 10.7 3.0 1 1 1 3 3 3 0 Golgi transport complex subunit 5 RRM_3 PF08777.11 KOO24888.1 - 0.00088 19.3 0.0 0.0017 18.4 0.0 1.4 1 0 0 1 1 1 1 RNA binding motif Paf1 PF03985.13 KOO24888.1 - 0.036 13.1 3.3 0.041 12.9 3.3 1.0 1 0 0 1 1 1 0 Paf1 AAA_6 PF12774.7 KOO24889.1 - 1.9e-154 513.5 0.0 1.2e-153 510.8 0.0 2.4 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO24889.1 - 3.5e-123 411.6 1.5 3.5e-123 411.6 1.5 4.8 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO24889.1 - 1.3e-97 326.2 0.0 3.7e-97 324.7 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KOO24889.1 - 8.1e-87 291.3 0.2 3.3e-85 286.0 0.0 2.9 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 KOO24889.1 - 3.2e-72 241.8 0.0 8.9e-68 227.4 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_9 PF12781.7 KOO24889.1 - 1.5e-68 230.2 2.4 1.5e-68 230.2 2.4 3.9 3 1 1 4 4 3 2 ATP-binding dynein motor region AAA_lid_11 PF18198.1 KOO24889.1 - 1.3e-56 190.9 0.0 3e-56 189.7 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 KOO24889.1 - 4.4e-49 167.3 14.5 4.4e-49 167.3 14.5 1.7 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KOO24889.1 - 2.3e-37 127.7 0.0 4.3e-33 113.9 0.0 3.9 2 1 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 KOO24889.1 - 2.3e-26 92.4 0.1 9.5e-26 90.4 0.1 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain DHC_N1 PF08385.12 KOO24889.1 - 1.1e-21 77.1 0.0 1.1e-21 77.1 0.0 4.2 2 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 AAA_5 PF07728.14 KOO24889.1 - 7.6e-20 71.3 0.1 3.7e-06 27.0 0.0 5.5 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 KOO24889.1 - 6.4e-15 55.2 1.5 2.7e-14 53.2 0.1 2.7 3 0 0 3 3 2 1 AAA+ lid domain AAA_16 PF13191.6 KOO24889.1 - 3.1e-06 27.7 0.1 0.065 13.6 0.0 4.1 3 1 1 4 4 3 2 AAA ATPase domain AAA PF00004.29 KOO24889.1 - 3.1e-05 24.4 1.8 0.59 10.6 0.0 4.4 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOO24889.1 - 0.00012 22.4 0.1 0.34 11.2 0.0 4.0 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 KOO24889.1 - 0.014 15.9 0.1 3.4 8.2 0.0 3.7 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 KOO24889.1 - 0.024 14.4 2.0 32 4.2 0.0 4.3 4 0 0 4 4 4 0 AAA domain DUF1376 PF07120.11 KOO24889.1 - 0.042 14.2 1.2 0.69 10.3 0.2 3.2 3 0 0 3 3 2 0 Protein of unknown function (DUF1376) FTA4 PF13093.6 KOO24889.1 - 0.1 12.5 1.0 0.66 9.8 1.0 2.5 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 TPT PF03151.16 KOO24890.1 - 2.8e-07 30.2 18.0 3.6e-07 29.8 18.0 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO24890.1 - 1.2e-05 25.5 27.6 0.00023 21.3 9.8 2.8 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO24890.1 - 0.00018 20.9 24.3 0.0005 19.4 24.3 1.8 1 1 0 1 1 1 1 UAA transporter family TAF1_subA PF14929.6 KOO24890.1 - 0.18 11.2 0.6 0.26 10.7 0.6 1.2 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A Lar_restr_allev PF14354.6 KOO24891.1 - 0.23 11.9 12.9 10 6.6 0.1 3.9 3 1 0 3 3 3 0 Restriction alleviation protein Lar zf-UDP PF14569.6 KOO24891.1 - 0.35 11.0 8.8 19 5.5 0.2 3.5 3 0 0 3 3 3 0 Zinc-binding RING-finger zf-C4pol PF14260.6 KOO24891.1 - 0.63 10.5 6.0 17 5.9 0.2 3.1 3 0 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta Zn_Tnp_IS1595 PF12760.7 KOO24891.1 - 2 8.4 11.2 7.1 6.7 0.2 3.4 3 0 0 3 3 3 0 Transposase zinc-ribbon domain SoxD PF04267.12 KOO24891.1 - 3.3 7.9 7.7 14 5.9 0.2 4.1 3 1 0 3 3 3 0 Sarcosine oxidase, delta subunit family zf-C2H2_9 PF16293.5 KOO24891.1 - 4.7 7.1 4.9 16 5.4 0.2 3.0 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Myb_DNA-binding PF00249.31 KOO24892.1 - 1.6e-14 53.8 0.2 3.3e-14 52.8 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO24892.1 - 3e-07 30.6 0.3 5.3e-07 29.8 0.3 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO24892.1 - 0.0019 18.0 0.0 0.0033 17.3 0.0 1.3 1 0 0 1 1 1 1 Myb DNA-binding like Zn_ribbon_SprT PF17283.2 KOO24892.1 - 0.14 12.1 1.1 0.27 11.2 1.1 1.4 1 0 0 1 1 1 0 SprT-like zinc ribbon domain Ribosomal_S2 PF00318.20 KOO24894.1 - 5.5e-37 127.1 0.0 6.6e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S2 PET117 PF15786.5 KOO24895.1 - 0.038 14.3 2.7 2.4 8.5 1.3 3.2 2 0 0 2 2 2 0 PET assembly of cytochrome c oxidase, mitochondrial Dpy-30 PF05186.13 KOO24896.1 - 0.093 12.4 0.1 0.26 11.0 0.1 1.8 1 0 0 1 1 1 0 Dpy-30 motif Ank_4 PF13637.6 KOO24897.1 - 1.5e-45 153.0 6.5 2.1e-13 50.5 0.0 6.0 3 1 4 7 7 7 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO24897.1 - 9.7e-32 109.4 1.0 6.9e-09 36.2 0.0 4.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO24897.1 - 1.5e-24 83.3 0.2 0.0011 19.3 0.0 7.7 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 KOO24897.1 - 1.4e-23 82.2 1.0 0.00027 21.2 0.0 5.9 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 KOO24897.1 - 1.7e-22 79.2 2.2 1.2e-05 25.5 0.3 7.2 1 1 5 6 6 6 5 Ankyrin repeats (many copies) DHHC PF01529.20 KOO24897.1 - 5.1e-22 78.4 11.0 1.9e-21 76.6 11.0 1.9 1 1 0 1 1 1 1 DHHC palmitoyltransferase PPR_3 PF13812.6 KOO24898.1 - 0.0029 17.6 0.0 0.12 12.4 0.0 2.4 1 1 1 2 2 2 2 Pentatricopeptide repeat domain Nterm_IS4 PF13006.7 KOO24898.1 - 0.071 13.3 0.8 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 Insertion element 4 transposase N-terminal PPR_2 PF13041.6 KOO24898.1 - 0.14 12.4 0.0 17 5.7 0.0 2.4 2 0 0 2 2 2 0 PPR repeat family PABP PF00658.18 KOO24899.1 - 1.7e-14 53.7 0.1 3.3e-14 52.8 0.1 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RNA_GG_bind PF10258.9 KOO24899.1 - 5.9e-12 45.5 0.0 1.3e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 PHAX RNA-binding domain F-box-like PF12937.7 KOO24899.1 - 0.087 12.7 0.2 0.26 11.2 0.2 1.7 1 0 0 1 1 1 0 F-box-like ApoLp-III PF07464.11 KOO24900.1 - 0.015 15.4 17.8 0.05 13.7 1.0 2.6 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) LapD_MoxY_N PF16448.5 KOO24900.1 - 0.25 11.2 5.8 2 8.3 0.7 2.4 2 0 0 2 2 2 0 LapD/MoxY periplasmic domain DUF842 PF05811.13 KOO24900.1 - 1.1 8.9 10.7 5.4 6.7 5.7 3.4 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF842) DUF1319 PF07028.11 KOO24900.1 - 3 8.1 7.4 1.1 9.5 0.2 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1319) WD40 PF00400.32 KOO24902.1 - 1.9e-24 85.4 15.0 4.1e-08 33.8 0.0 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO24902.1 - 7.6e-05 22.9 0.0 0.049 13.9 0.0 4.3 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain bZIP_1 PF00170.21 KOO24902.1 - 0.029 14.5 0.7 0.052 13.7 0.7 1.3 1 0 0 1 1 1 0 bZIP transcription factor Ge1_WD40 PF16529.5 KOO24902.1 - 0.1 11.5 0.1 0.16 10.9 0.1 1.2 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TLC PF03219.14 KOO24903.1 - 1.3e-178 594.8 10.3 1.6e-178 594.4 10.3 1.0 1 0 0 1 1 1 1 TLC ATP/ADP transporter MFS_1 PF07690.16 KOO24903.1 - 0.82 8.5 44.1 1.3 7.9 29.9 2.2 1 1 1 2 2 2 0 Major Facilitator Superfamily ATP_transf PF09830.9 KOO24904.1 - 0.015 15.5 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 ATP adenylyltransferase DoxA PF07680.11 KOO24905.1 - 0.11 12.5 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 TQO small subunit DoxA EF-hand_6 PF13405.6 KOO24906.1 - 0.11 12.5 0.7 0.72 9.9 0.0 2.5 3 0 0 3 3 3 0 EF-hand domain CENP-Q PF13094.6 KOO24906.1 - 0.2 11.9 6.3 0.6 10.3 6.3 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit EF-hand_5 PF13202.6 KOO24906.1 - 1 9.0 4.2 1.9 8.2 0.1 2.8 3 0 0 3 3 3 0 EF hand DUF1155 PF06633.11 KOO24908.1 - 0.43 10.1 2.1 1.7 8.2 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1155) Allexi_40kDa PF05549.11 KOO24909.1 - 1 8.8 6.8 2.4 7.6 0.4 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein PIN_8 PF18476.1 KOO24909.1 - 5.4 6.8 10.4 1.1 9.1 4.9 2.1 1 1 1 2 2 2 0 PIN like domain Cytochrom_C552 PF02335.15 KOO24909.1 - 6.3 5.6 14.2 9.8 5.0 14.2 1.3 1 0 0 1 1 1 0 Cytochrome c552 adh_short PF00106.25 KOO24910.1 - 1.3e-24 86.8 0.1 2e-24 86.2 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO24910.1 - 4.6e-19 68.9 0.3 7.8e-19 68.1 0.3 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO24910.1 - 9.2e-13 48.5 0.2 1.5e-12 47.8 0.2 1.3 1 0 0 1 1 1 1 KR domain NAP PF00956.18 KOO24910.1 - 0.00021 20.6 0.1 0.00096 18.4 0.0 1.9 1 1 1 2 2 2 1 Nucleosome assembly protein (NAP) Phage_TAC_7 PF10109.9 KOO24910.1 - 0.0085 16.2 0.0 0.031 14.4 0.0 2.0 2 0 0 2 2 2 1 Phage tail assembly chaperone proteins, E, or 41 or 14 VWA_CoxE PF05762.14 KOO24910.1 - 0.04 13.3 0.5 0.04 13.3 0.5 1.6 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein Transglut_core PF01841.19 KOO24911.1 - 0.0004 20.8 0.0 0.0012 19.2 0.0 1.9 1 1 0 1 1 1 1 Transglutaminase-like superfamily STG PF15809.5 KOO24912.1 - 2.3 8.2 14.4 0.38 10.8 0.7 2.5 2 0 0 2 2 2 0 Simian taste bud-specific gene product family Sulfotransfer_3 PF13469.6 KOO24915.1 - 3.5e-14 53.7 1.1 6.2e-14 52.9 0.0 1.9 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO24915.1 - 0.0001 21.9 0.0 0.00025 20.6 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase domain LRR_6 PF13516.6 KOO24916.1 - 0.0001 22.0 5.3 1.3 9.3 0.0 4.0 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 KOO24916.1 - 0.02 15.3 1.6 0.33 11.4 0.1 2.3 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) Romo1 PF10247.9 KOO24917.1 - 3.6e-15 56.1 7.8 5.7e-15 55.4 6.4 1.8 2 0 0 2 2 2 1 Reactive mitochondrial oxygen species modulator 1 EF-hand_1 PF00036.32 KOO24918.1 - 3.5e-24 82.5 5.4 1.1e-05 24.6 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO24918.1 - 1.9e-21 76.3 2.7 4e-10 40.0 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO24918.1 - 4e-21 73.1 5.0 0.0007 19.3 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO24918.1 - 1.5e-18 65.4 2.6 2.5e-05 23.5 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO24918.1 - 2e-14 53.2 2.1 2e-05 24.4 0.0 3.9 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO24918.1 - 9.7e-09 35.6 1.8 0.00061 20.1 0.5 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO24918.1 - 0.0014 18.4 1.3 1.5 8.8 0.0 3.2 2 2 2 4 4 4 2 EF hand DUF5580 PF17743.1 KOO24918.1 - 0.0066 15.0 0.3 0.027 13.0 0.2 1.9 1 1 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_4 PF12763.7 KOO24918.1 - 0.0076 16.2 2.1 1.1 9.2 0.1 3.3 2 2 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand Sigma70_r1_1 PF03979.14 KOO24918.1 - 0.0086 16.1 0.1 1.3 9.1 0.0 2.8 2 0 0 2 2 2 1 Sigma-70 factor, region 1.1 Toprim_2 PF13155.6 KOO24918.1 - 0.02 15.3 5.0 4.4 7.8 0.1 4.1 1 1 2 4 4 4 0 Toprim-like PMBR PF09373.10 KOO24918.1 - 0.073 13.3 0.0 1.5 9.1 0.0 2.8 3 0 0 3 3 3 0 Pseudomurein-binding repeat Toprim_4 PF13662.6 KOO24918.1 - 0.076 13.5 0.6 4 8.0 0.0 3.2 4 0 0 4 4 4 0 Toprim domain Transcript_VP30 PF11507.8 KOO24918.1 - 0.093 12.8 0.3 0.79 9.8 0.0 2.6 3 1 1 4 4 4 0 Ebola virus-specific transcription factor VP30 GLTSCR1 PF15249.6 KOO24918.1 - 0.22 12.0 1.8 9.2 6.8 0.2 2.4 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein Peptidase_C48 PF02902.19 KOO24919.1 - 5.5e-11 42.7 0.1 3e-08 33.8 0.0 2.3 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain Arm PF00514.23 KOO24920.1 - 4.4e-20 71.0 31.7 0.0015 18.5 0.1 8.7 9 1 1 10 10 10 7 Armadillo/beta-catenin-like repeat Ank_4 PF13637.6 KOO24920.1 - 1.4e-09 38.3 2.0 3.6e-05 24.2 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO24920.1 - 4.6e-08 33.5 2.8 5e-08 33.4 0.4 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO24920.1 - 1.5e-06 28.4 0.8 4.7e-06 26.8 0.8 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO24920.1 - 0.00029 21.1 4.0 0.0095 16.4 0.4 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 KOO24920.1 - 0.00088 19.6 1.2 0.11 13.1 0.1 3.8 3 0 0 3 3 3 1 Ankyrin repeat Nucleoporin_FG PF13634.6 KOO24920.1 - 0.021 15.7 2.3 0.056 14.3 2.3 1.7 1 0 0 1 1 1 0 Nucleoporin FG repeat region HEAT PF02985.22 KOO24920.1 - 0.15 12.4 8.7 6.4 7.3 0.0 6.2 7 1 0 7 7 7 0 HEAT repeat SAM_2 PF07647.17 KOO24921.1 - 3.4e-07 30.3 0.2 6.2e-07 29.4 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KOO24921.1 - 3e-06 27.6 0.1 5.5e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Spc7 PF08317.11 KOO24921.1 - 3.7 6.3 8.1 6.8 5.5 8.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein YL1 PF05764.13 KOO24922.1 - 1.4e-32 113.8 20.3 1.9e-32 113.4 20.3 1.1 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.11 KOO24922.1 - 3.3e-11 42.7 1.3 1e-10 41.2 0.1 2.1 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain FGGY_C PF02782.16 KOO24922.1 - 0.069 12.9 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Apt1 PF10351.9 KOO24922.1 - 5 5.9 8.8 6.7 5.5 8.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain EF-hand_1 PF00036.32 KOO24923.1 - 2.8e-25 85.9 0.9 2.3e-06 26.8 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO24923.1 - 7.7e-23 78.4 2.8 1.1e-05 24.9 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO24923.1 - 1.7e-21 76.5 1.5 1.9e-09 37.8 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO24923.1 - 2e-19 69.2 1.4 4.7e-10 39.2 0.1 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO24923.1 - 2.7e-15 55.1 4.1 0.0011 18.4 0.1 4.4 4 0 0 4 4 4 4 EF hand NADPH_Ox PF08414.10 KOO24923.1 - 0.0052 17.1 0.1 1.3 9.4 0.0 2.3 2 0 0 2 2 2 1 Respiratory burst NADPH oxidase EF-hand_10 PF14788.6 KOO24923.1 - 0.0065 16.3 1.9 1.8 8.5 0.1 3.6 2 2 2 4 4 4 1 EF hand Caleosin PF05042.13 KOO24923.1 - 0.025 14.5 0.1 6.2 6.7 0.0 3.5 2 2 2 4 4 4 0 Caleosin related protein Porin_5 PF16930.5 KOO24923.1 - 0.044 12.3 0.8 0.067 11.7 0.8 1.2 1 0 0 1 1 1 0 Putative porin SHIPPO-rpt PF07004.12 KOO24923.1 - 0.063 14.2 16.1 0.21 12.6 1.8 4.4 4 0 0 4 4 4 0 Sperm-tail PG-rich repeat GCS PF03074.16 KOO24927.1 - 1.8e-143 478.4 0.0 2.3e-143 478.0 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase SLIDE PF09111.10 KOO24927.1 - 0.071 13.1 0.0 0.47 10.5 0.0 2.1 2 0 0 2 2 2 0 SLIDE DUF4620 PF15399.6 KOO24927.1 - 0.13 12.6 1.9 0.58 10.5 1.9 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4620) WD40 PF00400.32 KOO24928.1 - 4.4e-38 128.6 12.3 6.1e-07 30.0 0.2 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO24928.1 - 1e-06 28.9 0.1 5.8 7.3 0.0 6.5 4 3 4 8 8 8 1 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 KOO24928.1 - 0.0012 18.5 0.1 0.0023 17.5 0.1 1.5 1 0 0 1 1 1 1 LisH-like dimerisation domain LisH PF08513.11 KOO24928.1 - 0.0047 16.8 0.0 0.021 14.8 0.0 2.1 2 0 0 2 2 2 1 LisH PDEase_I PF00233.19 KOO24928.1 - 0.1 12.3 0.2 0.24 11.1 0.2 1.6 1 1 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase AGH PF17558.2 KOO24929.1 - 0.1 12.7 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Androgenic gland hormone ADH_N PF08240.12 KOO24931.1 - 1.2e-22 79.8 5.0 1.7e-22 79.4 4.1 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOO24931.1 - 1e-18 67.6 0.3 1.9e-18 66.7 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOO24931.1 - 4.5e-11 42.7 0.2 7.7e-11 41.9 0.2 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 KOO24931.1 - 2.7e-06 28.5 0.0 5.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glyco_hydro_20 PF00728.22 KOO24932.1 - 6.5e-83 279.0 0.1 9.5e-83 278.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 KOO24932.1 - 3.2e-12 47.3 0.0 1.1e-11 45.5 0.0 1.9 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 KOO24932.1 - 5.5e-07 30.4 0.0 1.1e-06 29.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Metallophos PF00149.28 KOO24933.1 - 4.9e-25 89.2 0.0 5.6e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WD40 PF00400.32 KOO24934.1 - 8.6e-41 137.2 12.5 2e-09 37.9 0.1 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO24934.1 - 8.7e-14 51.2 2.2 0.013 14.5 0.1 4.1 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO24934.1 - 1.3e-10 41.4 1.4 0.062 13.6 0.1 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO24934.1 - 2.1e-10 40.3 1.7 0.85 9.6 0.0 4.5 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 KOO24934.1 - 7.1e-06 25.6 1.4 0.3 10.4 0.0 3.4 1 1 3 4 4 4 3 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 KOO24934.1 - 3.3e-05 22.4 0.0 0.015 13.6 0.0 2.8 1 1 2 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz rOmpB PF12334.8 KOO24934.1 - 0.0016 18.0 2.4 0.94 8.9 0.2 3.4 1 1 2 3 3 3 2 Rickettsia outer membrane protein B WD40_3 PF15911.5 KOO24934.1 - 0.0053 16.7 0.2 5.6 7.0 0.0 3.9 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF4909 PF16253.5 KOO24934.1 - 0.052 13.4 0.1 1.3 8.9 0.0 2.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4909) P22_Tail-4 PF11650.8 KOO24934.1 - 0.092 12.7 0.1 23 4.9 0.0 3.2 2 2 2 4 4 4 0 P22 tail accessory factor LigD_N PF13298.6 KOO24934.1 - 0.095 13.0 0.6 8.7 6.7 0.1 3.0 1 1 1 2 2 2 0 DNA polymerase Ligase (LigD) GluRS_N PF18466.1 KOO24934.1 - 0.83 10.1 8.5 14 6.2 0.2 4.1 4 0 0 4 4 4 0 Glutamate--tRNA ligase N-terminal domain Proteasome_A_N PF10584.9 KOO24934.1 - 1.2 8.9 7.1 1e+02 2.7 0.1 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature PRIMA1 PF16101.5 KOO24936.1 - 0.39 10.8 2.9 0.52 10.4 0.3 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 RRM_1 PF00076.22 KOO24937.1 - 8.5e-34 115.2 0.0 1.8e-08 34.1 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4283 PF14111.6 KOO24937.1 - 0.089 12.3 0.0 13 5.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4283) RRM_3 PF08777.11 KOO24937.1 - 0.22 11.6 0.0 2.5 8.2 0.0 2.6 3 0 0 3 3 3 0 RNA binding motif Peptidase_S10 PF00450.22 KOO24938.1 - 1.6e-77 261.7 0.0 2e-77 261.4 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Phage_TAC_9 PF10876.8 KOO24939.1 - 0.037 14.1 0.0 0.063 13.4 0.0 1.4 1 0 0 1 1 1 0 Phage tail assemb.y chaperone protein, TAC ADPrib_exo_Tox PF03496.14 KOO24940.1 - 2.2e-05 23.9 0.0 4.4e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO24940.1 - 0.00018 20.8 0.0 0.00039 19.8 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_6 PF13516.6 KOO24940.1 - 0.03 14.4 16.5 0.93 9.7 0.0 7.0 7 0 0 7 7 7 0 Leucine Rich repeat CCDC84 PF14968.6 KOO24942.1 - 0.22 11.1 2.1 0.28 10.8 2.1 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 Ribosomal_60s PF00428.19 KOO24942.1 - 5.4 7.7 13.0 0.18 12.4 6.0 2.1 2 1 0 2 2 2 0 60s Acidic ribosomal protein FKBP_C PF00254.28 KOO24943.1 - 4.2e-29 100.7 0.0 6.4e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 KOO24943.1 - 0.036 15.0 1.0 0.054 14.4 1.0 1.3 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Asp PF00026.23 KOO24947.1 - 5.9e-24 85.1 0.2 1.6e-14 54.0 0.1 2.4 2 0 0 2 2 2 2 Eukaryotic aspartyl protease NYN_YacP PF05991.11 KOO24947.1 - 1.9e-06 27.9 0.0 4.4e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 YacP-like NYN domain TAXi_N PF14543.6 KOO24947.1 - 4.2e-05 23.9 4.1 0.00034 20.9 1.1 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOO24947.1 - 0.0026 18.3 0.1 0.41 11.3 0.0 3.5 3 0 0 3 3 3 1 Aspartyl protease TAXi_C PF14541.6 KOO24947.1 - 0.0035 17.1 0.0 0.026 14.3 0.0 2.2 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal GATase_7 PF13537.6 KOO24948.1 - 5.1e-09 36.1 0.0 7e-08 32.4 0.0 2.4 2 1 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 KOO24948.1 - 2.2e-05 24.7 0.0 7.3e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain Glyco_transf_4 PF13439.6 KOO24948.1 - 0.063 13.3 1.1 0.22 11.5 0.3 2.1 2 0 0 2 2 2 0 Glycosyltransferase Family 4 VCX_VCY PF15231.6 KOO24949.1 - 0.017 15.8 2.5 0.035 14.8 2.5 1.5 1 0 0 1 1 1 0 Variable charge X/Y family GDPD PF03009.17 KOO24951.1 - 2.1e-33 116.1 0.0 2.9e-21 76.4 0.0 4.5 3 2 0 3 3 3 3 Glycerophosphoryl diester phosphodiesterase family DUF1325 PF07039.11 KOO24951.1 - 0.014 15.4 0.1 6.1 6.9 0.0 2.4 2 0 0 2 2 2 0 SGF29 tudor-like domain Terpene_synth PF01397.21 KOO24951.1 - 0.24 11.1 0.0 18 4.9 0.0 2.3 2 0 0 2 2 2 0 Terpene synthase, N-terminal domain Ribosomal_S8 PF00410.19 KOO24952.1 - 6.7e-20 71.3 0.0 8.7e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 GHD PF17834.1 KOO24952.1 - 0.19 11.8 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 Beta-sandwich domain in beta galactosidase Ion_trans PF00520.31 KOO24953.1 - 9.1e-25 87.3 19.4 1.4e-24 86.7 19.4 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO24953.1 - 2.4e-11 43.4 7.3 2.4e-11 43.4 7.3 2.2 2 0 0 2 2 2 1 Ion channel cNMP_binding PF00027.29 KOO24953.1 - 2.6e-11 43.5 0.0 4.7e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PDZ PF00595.24 KOO24956.1 - 2e-07 31.3 3.0 0.042 14.2 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KOO24956.1 - 2.8e-05 23.8 3.9 1.5 8.7 0.0 3.8 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KOO24956.1 - 0.00074 19.8 4.4 0.23 11.8 0.1 3.7 3 0 0 3 3 3 1 PDZ domain FAA_hydrolase_N PF09298.11 KOO24956.1 - 0.005 17.0 3.2 5.2 7.3 0.5 3.8 3 1 0 3 3 3 1 Fumarylacetoacetase N-terminal Lambda_CIII PF02061.16 KOO24956.1 - 0.16 12.1 0.3 16 5.6 0.0 2.6 2 0 0 2 2 2 0 Lambda Phage CIII GATase_6 PF13522.6 KOO24962.1 - 1.2e-13 51.5 0.0 5.5e-13 49.3 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KOO24962.1 - 2.2e-13 50.2 0.0 8.3e-13 48.3 0.0 2.0 2 1 0 2 2 2 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 KOO24962.1 - 7.6e-07 28.8 0.0 1.6e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 KOO24962.1 - 0.02 13.8 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferases class-II DUF1471 PF07338.13 KOO24962.1 - 0.038 14.0 0.2 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) Pkinase PF00069.25 KOO24963.1 - 1.5e-66 224.5 0.0 2e-66 224.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24963.1 - 5.9e-31 107.7 1.1 6e-31 107.7 0.1 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO24963.1 - 2.4e-05 23.5 0.1 3.7e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KOO24963.1 - 0.0045 15.8 1.6 0.018 13.8 0.0 2.4 2 1 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 KOO24963.1 - 0.011 15.1 4.5 0.016 14.5 0.3 2.6 2 1 1 3 3 3 0 Kinase-like APH PF01636.23 KOO24963.1 - 0.024 14.6 2.0 0.05 13.5 0.4 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO24963.1 - 0.043 13.2 1.6 0.086 12.2 1.6 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Flp_Fap PF04964.14 KOO24964.1 - 0.13 12.1 1.8 0.27 11.1 1.8 1.5 1 0 0 1 1 1 0 Flp/Fap pilin component COX3 PF00510.18 KOO24964.1 - 0.13 12.0 0.6 0.2 11.4 0.6 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit III DIOX_N PF14226.6 KOO24965.1 - 1.3e-22 80.8 0.0 2.4e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 KOO24965.1 - 1.4e-20 73.7 0.1 2.6e-20 72.8 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zw10 PF06248.13 KOO24966.1 - 6.5e-24 84.4 0.0 1.4e-17 63.5 0.0 2.1 2 0 0 2 2 2 2 Centromere/kinetochore Zw10 Tenui_N PF05733.11 KOO24966.1 - 1.2 8.7 3.2 1.9 7.9 0.2 2.1 2 0 0 2 2 2 0 Tenuivirus/Phlebovirus nucleocapsid protein SHIPPO-rpt PF07004.12 KOO24967.1 - 0.00032 21.5 4.0 0.0028 18.5 2.0 2.8 2 1 0 2 2 2 1 Sperm-tail PG-rich repeat GrpE PF01025.19 KOO24968.1 - 2.7e-28 98.7 0.1 1.5e-25 89.8 0.0 2.1 2 0 0 2 2 2 2 GrpE TPR_MLP1_2 PF07926.12 KOO24968.1 - 0.011 15.8 1.0 0.025 14.6 1.0 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein TolA_bind_tri PF16331.5 KOO24968.1 - 0.34 11.0 5.3 0.46 10.6 3.5 1.9 2 0 0 2 2 2 0 TolA binding protein trimerisation GDP_Man_Dehyd PF16363.5 KOO24969.1 - 1.4e-61 208.7 0.0 2.2e-61 208.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOO24969.1 - 8.3e-56 189.1 0.0 1.1e-55 188.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO24969.1 - 1.8e-17 63.3 0.0 6.3e-17 61.5 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KOO24969.1 - 7e-15 54.9 0.0 1e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KOO24969.1 - 7.3e-15 54.9 0.0 4e-14 52.4 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 KOO24969.1 - 2.5e-08 33.6 0.4 3.8e-08 33.0 0.4 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 KOO24969.1 - 9.2e-08 31.6 0.1 3.2e-06 26.5 0.1 2.4 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 KOO24969.1 - 2.7e-07 30.7 0.3 5.4e-07 29.7 0.3 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 KOO24969.1 - 4.3e-06 26.8 0.0 7.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO24969.1 - 3.4e-05 23.5 0.4 0.0015 18.2 0.3 2.1 2 0 0 2 2 2 1 NmrA-like family adh_short_C2 PF13561.6 KOO24969.1 - 0.046 13.3 0.2 0.074 12.6 0.2 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Pkinase PF00069.25 KOO24970.1 - 4.3e-58 196.8 0.0 5.1e-58 196.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO24970.1 - 7.4e-26 91.0 0.0 1.1e-25 90.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO24970.1 - 1.2e-06 28.0 0.0 1.5e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOO24970.1 - 0.0024 16.9 0.0 0.0045 16.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOO24970.1 - 0.0037 16.6 0.0 0.0057 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO24970.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOO24970.1 - 0.11 12.1 0.1 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase LBR_tudor PF09465.10 KOO24971.1 - 0.017 14.9 0.3 0.043 13.6 0.0 1.7 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain Bromodomain PF00439.25 KOO24972.1 - 1.6e-16 60.1 0.0 3.6e-16 59.0 0.0 1.6 2 0 0 2 2 2 1 Bromodomain Acetyltransf_10 PF13673.7 KOO24972.1 - 0.00061 19.7 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain LysM PF01476.20 KOO24972.1 - 0.0096 16.0 0.0 1.5 8.9 0.0 2.4 2 0 0 2 2 2 2 LysM domain Acetyltransf_7 PF13508.7 KOO24972.1 - 0.087 13.3 0.1 0.29 11.6 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain EF-hand_1 PF00036.32 KOO24973.1 - 8.1e-36 118.9 19.3 2.2e-06 26.8 0.2 6.4 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO24973.1 - 2.6e-33 111.1 15.4 0.00012 21.7 0.2 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.6 KOO24973.1 - 1.8e-32 111.6 11.7 1.7e-10 41.2 0.4 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO24973.1 - 1.6e-29 100.0 23.5 9.2e-07 28.1 0.3 6.5 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.6 KOO24973.1 - 4.9e-25 87.1 17.0 1.5e-09 37.6 1.4 5.9 3 3 3 6 6 6 6 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO24973.1 - 1.9e-06 28.1 1.0 3.8 7.9 0.0 5.1 3 2 2 5 5 5 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO24973.1 - 0.00094 19.2 0.4 8.9 6.2 0.2 4.9 4 2 2 6 6 6 1 Caleosin related protein EF-hand_10 PF14788.6 KOO24973.1 - 0.0018 18.1 4.6 1.3 9.0 0.1 4.6 4 1 1 5 5 5 2 EF hand p25-alpha PF05517.12 KOO24973.1 - 0.0052 17.0 0.4 0.085 13.0 0.1 2.9 2 1 1 3 3 3 1 p25-alpha DUF1456 PF07308.13 KOO24973.1 - 0.016 15.5 1.2 13 6.2 0.0 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1456) EspA PF03433.13 KOO24973.1 - 0.11 12.3 0.1 11 5.8 0.0 3.1 3 0 0 3 3 3 0 EspA-like secreted protein GCR1_C PF12550.8 KOO24973.1 - 0.12 12.7 0.0 43 4.5 0.0 3.2 3 0 0 3 3 3 0 Transcriptional activator of glycolytic enzymes EF-hand_4 PF12763.7 KOO24973.1 - 6 6.9 5.9 39 4.3 0.8 3.5 2 2 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Arf PF00025.21 KOO24974.1 - 1.1e-47 161.8 0.0 1.2e-47 161.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO24974.1 - 1.2e-09 38.3 0.0 1.5e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KOO24974.1 - 1.6e-09 37.5 0.0 1.8e-09 37.3 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KOO24974.1 - 3.7e-07 29.9 0.0 4.1e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO24974.1 - 7.3e-07 29.4 0.0 1.5e-06 28.4 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KOO24974.1 - 1.1e-06 28.2 0.0 1.4e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KOO24974.1 - 6.8e-05 22.2 0.0 0.0037 16.5 0.0 2.2 1 1 1 2 2 2 1 G-protein alpha subunit Dynamin_N PF00350.23 KOO24974.1 - 0.0002 21.4 0.0 0.012 15.7 0.0 2.2 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 KOO24974.1 - 0.00082 19.0 0.1 0.031 13.8 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 KOO24974.1 - 0.0064 16.1 0.0 0.33 10.5 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 KOO24974.1 - 0.013 15.1 0.1 0.016 14.8 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOO24974.1 - 0.061 13.9 0.0 0.083 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain Thymopoietin PF08198.11 KOO24974.1 - 0.063 12.9 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 Thymopoietin protein FeoB_N PF02421.18 KOO24974.1 - 0.069 12.7 0.2 2.3 7.7 0.2 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.6 KOO24974.1 - 0.074 13.4 0.3 0.32 11.3 0.3 1.7 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 KOO24974.1 - 0.099 12.5 0.0 5.9 6.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 KOO24974.1 - 0.14 11.9 0.3 0.59 9.9 0.0 2.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain WD40 PF00400.32 KOO24975.1 - 8.9e-41 137.1 13.8 1.8e-08 34.9 0.4 7.5 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO24975.1 - 7.8e-12 45.3 0.0 0.11 12.8 0.0 5.9 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 KOO24975.1 - 1.3e-10 40.6 2.3 3.6e-10 39.2 2.3 1.8 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like eIF2A PF08662.11 KOO24975.1 - 8e-06 25.9 0.0 1.1 9.1 0.0 3.5 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOO24975.1 - 3.4e-05 22.7 0.2 1.1 7.8 0.0 4.2 4 1 1 5 5 5 3 Nucleoporin Nup120/160 HxlR PF01638.17 KOO24975.1 - 0.059 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Ge1_WD40 PF16529.5 KOO24975.1 - 0.086 11.8 0.0 4.1 6.3 0.0 3.3 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein tRNA-synt_2 PF00152.20 KOO24976.1 - 1.5e-76 257.5 0.0 2.9e-76 256.5 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOO24976.1 - 5.2e-08 32.8 0.0 9.8e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF5582 PF17819.1 KOO24976.1 - 0.00026 21.5 0.0 0.00064 20.2 0.0 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5582) DUF5586 PF17824.1 KOO24976.1 - 0.005 16.0 0.3 0.0095 15.1 0.1 1.5 2 0 0 2 2 2 1 Family of unknown function (DUF5586) Dpy-30 PF05186.13 KOO24976.1 - 0.023 14.4 0.0 0.051 13.3 0.0 1.7 1 0 0 1 1 1 0 Dpy-30 motif Methyltransf_11 PF08241.12 KOO24977.1 - 4.4e-11 43.3 0.0 8.8e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO24977.1 - 1.4e-06 28.2 0.0 1.9e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO24977.1 - 4.3e-06 27.3 0.0 8.8e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO24977.1 - 1.3e-05 24.6 0.0 2.1e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 KOO24977.1 - 4.7e-05 22.1 0.0 6e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 KOO24977.1 - 6.4e-05 23.6 0.0 0.00011 22.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KOO24977.1 - 0.00035 20.5 0.0 0.00054 19.9 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_23 PF13489.6 KOO24977.1 - 0.00051 19.9 0.0 0.00068 19.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain EF-hand_6 PF13405.6 KOO24978.1 - 1.4e-32 108.8 20.0 1.5e-05 24.5 0.1 6.9 8 0 0 8 8 8 6 EF-hand domain EF-hand_7 PF13499.6 KOO24978.1 - 2.1e-27 95.4 18.4 1.6e-09 38.0 0.1 4.2 2 1 2 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.32 KOO24978.1 - 2.5e-25 86.1 22.6 4e-05 22.9 0.1 6.6 7 0 0 7 7 7 6 EF hand EF-hand_5 PF13202.6 KOO24978.1 - 3.9e-18 64.1 18.2 0.001 18.5 0.1 6.1 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO24978.1 - 4.3e-18 64.9 19.0 3.3e-07 30.0 0.0 6.3 3 2 3 6 6 6 6 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO24978.1 - 0.0039 17.5 3.2 4.1 7.8 0.0 4.1 4 1 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO24978.1 - 0.0049 17.2 0.2 14 6.1 0.0 3.8 3 1 1 4 4 4 1 EF-hand domain Armet PF10208.9 KOO24978.1 - 0.0065 16.4 0.0 1.2 9.0 0.0 2.4 2 0 0 2 2 2 1 Degradation arginine-rich protein for mis-folding Caleosin PF05042.13 KOO24978.1 - 0.0091 15.9 0.4 7 6.5 0.0 3.4 2 1 1 3 3 3 1 Caleosin related protein GIT_CC PF16559.5 KOO24978.1 - 0.047 13.6 0.0 2.5 8.0 0.0 2.5 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor TERF2_RBM PF16772.5 KOO24978.1 - 0.13 11.7 1.5 4.3 6.9 0.2 2.5 2 0 0 2 2 2 0 Telomeric repeat-binding factor 2 Rap1-binding motif EF-hand_4 PF12763.7 KOO24978.1 - 2.1 8.3 5.7 14 5.7 0.4 3.4 2 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand LmjF365940-deam PF14421.6 KOO24979.1 - 1.1e-51 175.2 0.4 1.4e-49 168.3 0.4 2.3 1 1 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases dCMP_cyt_deam_1 PF00383.23 KOO24979.1 - 0.00059 19.7 0.1 0.0038 17.1 0.1 2.1 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Response_reg PF00072.24 KOO24980.1 - 0.00035 20.7 0.0 0.00081 19.5 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain TTL PF03133.15 KOO24981.1 - 1e-92 310.4 0.3 1.4e-92 310.0 0.3 1.0 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO24981.1 - 2.4e-07 30.3 0.1 0.00064 19.1 0.0 2.7 2 1 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO24981.1 - 7.5e-05 22.1 0.1 0.00085 18.7 0.0 2.1 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp Apolipo_F PF15148.6 KOO24981.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein F tRNA-synt_2b PF00587.25 KOO24983.1 - 9e-37 126.8 0.0 1.5e-36 126.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KOO24983.1 - 3.1e-20 72.1 0.2 5.9e-20 71.2 0.2 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 KOO24983.1 - 1.4e-10 41.1 0.0 3.9e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 KOO24983.1 - 7.9e-10 38.6 0.0 2.7e-09 36.9 0.0 2.0 1 1 0 1 1 1 1 TGS domain HATPase_c PF02518.26 KOO24985.1 - 2.3e-25 89.3 0.0 7e-25 87.7 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOO24985.1 - 8.9e-18 64.5 0.0 2.6e-09 37.3 0.0 2.9 3 0 0 3 3 3 2 Response regulator receiver domain HisKA PF00512.25 KOO24985.1 - 1.3e-14 53.9 0.6 4.5e-14 52.2 0.0 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 KOO24985.1 - 3.5e-11 43.1 0.4 0.00013 21.9 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 KOO24985.1 - 1.4e-07 31.7 0.1 0.00033 20.9 0.1 2.7 2 0 0 2 2 2 2 PAS fold GAF PF01590.26 KOO24985.1 - 1.5e-06 28.8 0.0 2.2e-05 25.1 0.0 2.6 2 0 0 2 2 2 1 GAF domain Hpt PF01627.23 KOO24985.1 - 8.7e-06 25.9 1.0 3.1e-05 24.1 1.0 2.0 1 0 0 1 1 1 1 Hpt domain PAS_9 PF13426.7 KOO24985.1 - 0.0063 16.7 0.0 0.023 15.0 0.0 1.9 1 1 0 1 1 1 1 PAS domain PAS_8 PF13188.7 KOO24985.1 - 0.0075 16.3 0.1 0.058 13.4 0.0 2.4 2 0 0 2 2 2 1 PAS domain Exostosin PF03016.15 KOO24987.1 - 7.3e-44 150.2 0.0 9.5e-44 149.8 0.0 1.1 1 0 0 1 1 1 1 Exostosin family IFT46_B_C PF12317.8 KOO24988.1 - 1.3e-29 103.5 0.3 1.6e-29 103.2 0.3 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal ABC2_membrane_3 PF12698.7 KOO24989.1 - 9.2e-57 192.7 53.8 3.5e-30 105.3 26.0 3.1 3 1 0 3 3 3 2 ABC-2 family transporter protein ABC_tran PF00005.27 KOO24989.1 - 8.6e-51 172.1 0.0 2.2e-24 86.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO24989.1 - 4.8e-18 66.0 0.3 1.2e-08 35.2 0.0 4.4 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 KOO24989.1 - 8.4e-05 22.7 0.1 0.23 11.7 0.0 4.1 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 KOO24989.1 - 0.00053 19.5 0.0 0.75 9.2 0.0 3.4 3 1 0 4 4 4 1 RecF/RecN/SMC N terminal domain ABC2_membrane PF01061.24 KOO24989.1 - 0.00086 18.8 12.9 0.00086 18.8 12.9 3.3 3 0 0 3 3 2 1 ABC-2 type transporter AAA_29 PF13555.6 KOO24989.1 - 0.0035 17.1 2.6 0.41 10.4 0.4 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain MukB PF04310.12 KOO24989.1 - 0.011 15.5 4.2 0.19 11.5 0.8 2.3 2 0 0 2 2 2 0 MukB N-terminal DUF4162 PF13732.6 KOO24989.1 - 0.021 15.5 0.0 2.1 9.2 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4162) MeaB PF03308.16 KOO24989.1 - 0.022 13.8 2.2 0.28 10.1 0.1 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Mg_chelatase PF01078.21 KOO24989.1 - 0.043 13.2 0.5 2 7.8 0.1 3.2 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 KOO24989.1 - 0.054 14.0 3.9 2.5 8.5 0.4 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KOO24989.1 - 0.063 12.5 0.1 2.8 7.1 0.0 2.8 3 0 0 3 3 3 0 Zeta toxin SRP54 PF00448.22 KOO24989.1 - 0.29 10.7 3.7 4.5 6.9 0.9 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 KOO24989.1 - 0.36 10.9 1.9 9.6 6.3 0.1 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase Galactosyl_T PF01762.21 KOO24990.1 - 8.1e-09 35.6 0.0 1.3e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase 2OG-FeII_Oxy_3 PF13640.6 KOO24991.1 - 7.8e-17 62.0 0.1 1.1e-07 32.7 0.0 2.9 2 1 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO24991.1 - 7.6e-10 39.3 0.0 0.00066 20.3 0.0 3.2 3 0 0 3 3 3 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 KOO24991.1 - 0.0057 17.0 0.0 0.018 15.4 0.0 1.9 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy PF03171.20 KOO24991.1 - 0.041 14.4 0.4 0.13 12.7 0.0 2.0 2 1 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily SHIPPO-rpt PF07004.12 KOO24992.1 - 6.1e-12 45.9 10.8 0.26 12.3 0.0 5.7 5 0 0 5 5 5 5 Sperm-tail PG-rich repeat AIRC PF00731.20 KOO24993.1 - 2.1e-64 215.6 2.4 2.1e-64 215.6 2.4 2.4 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.22 KOO24993.1 - 3.4e-46 157.0 0.0 6e-46 156.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 KOO24993.1 - 5.1e-17 61.3 0.0 1.1e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 KOO24993.1 - 0.024 14.1 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 KOO24993.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Nramp PF01566.18 KOO24995.1 - 3.1e-99 332.4 8.4 4.1e-99 331.9 8.4 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Filamin PF00630.19 KOO24996.1 - 2.5e-16 60.4 0.0 1.9e-09 38.2 0.0 4.2 3 1 0 3 3 3 2 Filamin/ABP280 repeat EF-hand_1 PF00036.32 KOO24996.1 - 1.1e-06 27.8 0.3 5.3e-05 22.5 0.2 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO24996.1 - 1.4e-05 24.7 0.1 5.6e-05 22.8 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain Invasin_D3 PF09134.10 KOO24996.1 - 1.5e-05 25.2 0.0 5.8e-05 23.3 0.0 2.0 1 0 0 1 1 1 1 Invasin, domain 3 EF-hand_5 PF13202.6 KOO24996.1 - 2.1e-05 23.8 0.9 0.00012 21.4 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO24996.1 - 5.1e-05 23.6 0.1 0.00026 21.4 0.1 2.3 1 1 1 2 2 2 1 EF-hand domain pair DUF1492 PF07374.11 KOO24996.1 - 0.13 12.5 0.3 0.4 10.9 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) EF-hand_8 PF13833.6 KOO24996.1 - 0.16 11.8 0.4 0.5 10.3 0.2 1.9 2 0 0 2 2 2 0 EF-hand domain pair TF_Zn_Ribbon PF08271.12 KOO24996.1 - 0.17 11.4 0.7 3.5 7.2 0.1 2.3 1 1 1 2 2 2 0 TFIIB zinc-binding Ion_trans PF00520.31 KOO24997.1 - 4.9e-191 631.8 39.4 1.7e-52 178.1 4.1 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO24997.1 - 2.4e-11 43.0 43.3 4.1e-07 29.1 2.8 7.5 6 3 2 8 8 8 4 Polycystin cation channel GPHH PF16905.5 KOO24997.1 - 9.8e-11 41.3 0.1 2.5e-10 39.9 0.1 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Kelch_3 PF13415.6 KOO24997.1 - 1.6e-07 31.4 1.1 0.0023 18.2 0.1 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KOO24997.1 - 6.4e-07 29.1 4.8 0.0039 17.1 0.5 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KOO24997.1 - 2.6e-06 27.3 3.4 0.00089 19.2 0.5 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KOO24997.1 - 8.2e-05 22.1 0.7 0.026 14.1 0.4 2.6 2 0 0 2 2 2 2 Kelch motif IQ PF00612.27 KOO24997.1 - 9.8e-05 21.8 12.5 0.023 14.5 0.1 3.6 3 0 0 3 3 3 2 IQ calmodulin-binding motif Kelch_6 PF13964.6 KOO24997.1 - 0.0011 19.2 0.3 0.014 15.7 0.1 2.5 2 0 0 2 2 2 1 Kelch motif DnaJ PF00226.31 KOO24998.1 - 2e-25 88.7 3.8 2.9e-25 88.1 3.8 1.3 1 0 0 1 1 1 1 DnaJ domain DUF4314 PF14192.6 KOO24998.1 - 2.1e-05 24.3 0.1 0.0024 17.8 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4314) YajC PF02699.15 KOO24998.1 - 0.067 13.1 5.7 2.8 7.9 0.1 2.7 2 1 0 2 2 2 0 Preprotein translocase subunit KOW PF00467.29 KOO24998.1 - 0.23 11.5 1.1 1.3 9.0 0.3 2.6 3 0 0 3 3 3 0 KOW motif ANAPC4_WD40 PF12894.7 KOO24999.1 - 0.0088 16.3 0.0 0.22 11.8 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PIP5K PF01504.18 KOO25000.1 - 1.2e-61 208.3 0.1 3.4e-41 141.3 0.4 2.7 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_1 PF00036.32 KOO25000.1 - 5.6e-21 72.5 4.4 1.8e-05 24.0 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO25000.1 - 1.5e-20 73.4 5.8 2.3e-09 37.6 0.1 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO25000.1 - 1.8e-18 66.1 6.5 6.4e-06 25.9 0.1 4.6 4 1 1 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO25000.1 - 5.4e-18 63.3 6.1 0.0003 20.5 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO25000.1 - 2.2e-15 55.3 9.4 0.00013 21.3 0.2 4.5 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 KOO25000.1 - 0.045 14.1 0.0 5 7.5 0.0 2.8 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region FKBP_C PF00254.28 KOO25001.1 - 3.4e-15 56.1 0.0 9.2e-15 54.7 0.0 1.8 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_12 PF13424.6 KOO25001.1 - 1.8e-07 31.4 2.5 4.6e-07 30.0 2.5 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25001.1 - 3.7e-07 29.7 1.0 5.9e-05 22.7 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25001.1 - 6.7e-06 26.7 1.5 6.7e-06 26.7 1.5 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25001.1 - 2.2e-05 24.3 1.2 0.0012 18.9 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO25001.1 - 0.00018 21.4 11.3 0.00026 20.9 0.2 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO25001.1 - 0.0014 19.1 1.3 0.0048 17.4 0.3 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO25001.1 - 0.0047 17.1 0.6 0.0092 16.2 0.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 KOO25001.1 - 0.0053 16.4 1.2 0.045 13.5 0.2 2.6 2 0 0 2 2 2 1 TPR repeat TPR_14 PF13428.6 KOO25001.1 - 0.0066 17.2 7.0 0.036 14.9 0.9 3.6 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO25001.1 - 0.03 14.5 0.2 0.12 12.5 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TOM20_plant PF06552.12 KOO25001.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_6 PF13174.6 KOO25001.1 - 0.27 12.0 2.3 0.83 10.4 0.5 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO25001.1 - 2.9 7.9 4.9 40 4.3 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Atrophin-1 PF03154.15 KOO25001.1 - 3.7 5.7 7.9 5.8 5.1 7.9 1.2 1 0 0 1 1 1 0 Atrophin-1 family LMBR1 PF04791.16 KOO25002.1 - 5.6e-05 22.2 4.1 0.00013 21.1 4.1 1.5 1 1 0 1 1 1 1 LMBR1-like membrane protein DsbD_2 PF13386.6 KOO25002.1 - 0.0065 16.4 0.1 0.02 14.8 0.0 1.8 2 0 0 2 2 2 1 Cytochrome C biogenesis protein transmembrane region ArgoN PF16486.5 KOO25003.1 - 1e-07 32.7 0.0 5.7e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of argonaute NAPRTase_C PF17956.1 KOO25003.1 - 0.078 13.4 0.1 0.19 12.2 0.0 1.6 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain PP28 PF10252.9 KOO25003.1 - 0.091 13.2 0.2 0.091 13.2 0.2 1.9 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 Ion_trans PF00520.31 KOO25004.1 - 2.5e-33 115.4 3.8 2.8e-33 115.2 3.8 1.0 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO25004.1 - 1.6e-16 60.0 3.0 5.2e-16 58.4 3.0 1.9 1 0 0 1 1 1 1 Ion channel Gly_transf_sug PF04488.15 KOO25005.1 - 1e-13 51.7 0.0 1.6e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif ubiquitin PF00240.23 KOO25006.1 - 6.5e-20 70.7 0.0 8.6e-20 70.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family DNA_RNApol_7kD PF03604.13 KOO25006.1 - 4e-16 58.4 5.0 5.9e-16 57.9 5.0 1.3 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit Rad60-SLD PF11976.8 KOO25006.1 - 5.5e-09 35.7 0.0 1e-08 34.9 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 KOO25006.1 - 0.003 18.1 0.0 0.0034 17.9 0.0 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 KOO25006.1 - 0.013 15.6 0.0 0.02 15.0 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DZR PF12773.7 KOO25006.1 - 0.073 13.1 0.3 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon Ubiquitin_4 PF18036.1 KOO25006.1 - 0.13 12.3 0.1 2 8.5 0.0 2.1 1 1 1 2 2 2 0 Ubiquitin-like domain COG2 PF06148.11 KOO25007.1 - 0.031 14.4 1.2 0.033 14.3 1.2 1.0 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 V-ATPase_G PF03179.15 KOO25007.1 - 0.031 14.8 6.7 0.031 14.8 6.7 1.8 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit Plasmid_RAQPRD PF09686.10 KOO25007.1 - 0.17 12.1 6.7 0.15 12.3 5.6 1.5 1 1 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) ATP-synt_B PF00430.18 KOO25007.1 - 0.38 10.9 16.5 0.42 10.7 16.5 1.0 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Flot PF15975.5 KOO25007.1 - 5.7 7.1 13.8 7.8 6.7 13.4 1.4 1 1 0 1 1 1 0 Flotillin KIAA1430 PF13879.6 KOO25008.1 - 1.1e-07 32.5 28.5 0.00068 20.4 6.9 2.8 1 1 2 3 3 3 3 KIAA1430 homologue DUF4763 PF15960.5 KOO25008.1 - 0.086 12.1 5.4 0.2 11.0 5.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) DUF3135 PF11333.8 KOO25008.1 - 0.12 12.6 1.6 0.27 11.5 1.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3135) SlyX PF04102.12 KOO25008.1 - 0.66 10.6 6.5 2.9 8.6 0.8 3.5 3 0 0 3 3 3 0 SlyX NYD-SP28_assoc PF14775.6 KOO25008.1 - 5 7.3 12.5 1.3 9.2 0.6 3.4 4 0 0 4 4 4 0 Sperm tail C-terminal domain FF PF01846.19 KOO25009.1 - 4.4e-39 132.4 4.0 1.5e-11 44.3 0.2 4.6 4 0 0 4 4 4 4 FF domain WW PF00397.26 KOO25009.1 - 1.1e-18 67.0 16.5 3.5e-10 39.8 5.8 3.0 3 0 0 3 3 3 2 WW domain Glyco_hyd_101C PF17451.2 KOO25009.1 - 0.0046 17.2 3.7 0.75 10.1 0.3 2.5 2 0 0 2 2 2 2 Glycosyl hydrolase 101 beta sandwich domain SpoVAE PF14097.6 KOO25009.1 - 0.022 14.4 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Stage V sporulation protein AE1 SelP_N PF04592.14 KOO25009.1 - 0.79 9.1 7.6 1.4 8.2 7.6 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Neur_chan_memb PF02932.16 KOO25009.1 - 3 7.8 6.5 12 5.9 1.7 2.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region GCP_N_terminal PF17681.1 KOO25011.1 - 1e-18 68.0 0.0 1.2e-18 67.8 0.0 1.0 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Acetyltransf_1 PF00583.25 KOO25012.1 - 1.3e-07 31.9 0.0 2.3e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO25012.1 - 0.0044 17.4 0.0 0.0089 16.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO25012.1 - 0.0046 16.9 0.0 0.008 16.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KOO25012.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase GCP_C_terminal PF04130.13 KOO25013.1 - 3.1e-62 210.8 4.1 3.5e-62 210.6 4.1 1.0 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal DUF812 PF05667.11 KOO25014.1 - 0.008 15.1 18.9 0.37 9.6 17.9 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF812) Fib_alpha PF08702.10 KOO25014.1 - 0.055 13.6 1.7 9.3 6.4 0.0 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Pox_A_type_inc PF04508.12 KOO25014.1 - 0.11 12.3 0.5 1.4 8.9 0.1 2.9 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat AAA_13 PF13166.6 KOO25014.1 - 0.57 8.8 15.7 0.42 9.2 8.2 2.2 2 0 0 2 2 2 0 AAA domain MscS_porin PF12795.7 KOO25014.1 - 0.67 9.5 41.8 0.15 11.5 0.2 3.6 3 1 0 3 3 3 0 Mechanosensitive ion channel porin domain GPW_gp25 PF04965.14 KOO25014.1 - 0.83 9.5 8.5 4.7 7.1 0.2 3.9 3 1 1 4 4 4 0 Gene 25-like lysozyme DUF3450 PF11932.8 KOO25014.1 - 1.6 7.9 35.6 0.11 11.8 8.3 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) XhlA PF10779.9 KOO25014.1 - 4.3 7.6 5.7 32 4.8 0.0 4.1 4 1 1 5 5 5 0 Haemolysin XhlA FAM76 PF16046.5 KOO25014.1 - 5 6.4 10.5 0.6 9.4 4.5 2.2 3 0 0 3 3 3 0 FAM76 protein FH2 PF02181.23 KOO25014.1 - 5.9 5.9 9.8 1.2 8.2 5.6 1.8 2 0 0 2 2 2 0 Formin Homology 2 Domain CLZ PF16526.5 KOO25014.1 - 6 7.3 20.1 0.26 11.7 4.4 4.3 4 2 1 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Lebercilin PF15619.6 KOO25014.1 - 9.8 5.8 34.7 1.9 8.1 16.6 3.3 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease MIP PF00230.20 KOO25015.1 - 5.7e-25 88.3 27.1 2.4e-24 86.3 15.7 2.5 2 1 1 3 3 3 2 Major intrinsic protein DUF1700 PF08006.11 KOO25015.1 - 5.3 6.5 7.1 0.29 10.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Zip PF02535.22 KOO25016.1 - 4.8e-11 42.5 23.7 1.1e-08 34.7 3.7 2.9 2 1 1 3 3 3 3 ZIP Zinc transporter DUF1700 PF08006.11 KOO25016.1 - 0.049 13.2 0.1 0.11 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Tir_receptor_C PF07489.11 KOO25016.1 - 5.8 6.8 5.6 23 4.8 0.1 2.6 3 0 0 3 3 3 0 Translocated intimin receptor (Tir) C-terminus Ferric_reduct PF01794.19 KOO25017.1 - 4.5e-08 33.2 11.6 1e-07 32.1 11.6 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component Resolvase PF00239.21 KOO25017.1 - 0.043 13.9 0.6 0.094 12.8 0.6 1.5 1 0 0 1 1 1 0 Resolvase, N terminal domain SlyX PF04102.12 KOO25017.1 - 0.06 14.0 0.0 10 6.8 0.0 2.6 2 0 0 2 2 2 0 SlyX Lebercilin PF15619.6 KOO25017.1 - 0.065 12.9 2.1 5.2 6.7 0.5 2.2 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4336 PF14234.6 KOO25018.1 - 1.1e-104 350.1 0.0 1.5e-104 349.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4336) cNMP_binding PF00027.29 KOO25018.1 - 7e-12 45.3 0.0 7.8e-05 22.7 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RPAP1_C PF08620.10 KOO25018.1 - 0.88 9.7 2.9 74 3.6 0.0 4.5 4 0 0 4 4 4 0 RPAP1-like, C-terminal ADH_zinc_N PF00107.26 KOO25019.1 - 6.9e-22 77.8 0.2 1.2e-21 77.0 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 KOO25019.1 - 0.002 17.7 0.2 0.0032 17.1 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 KOO25019.1 - 0.0077 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 KOO25019.1 - 0.013 15.8 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 KOO25019.1 - 0.018 14.3 0.3 0.028 13.7 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF973 PF06157.11 KOO25020.1 - 0.0086 15.2 0.6 0.015 14.3 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF973) DUF4386 PF14329.6 KOO25020.1 - 0.029 14.2 3.0 0.029 14.2 3.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4386) DAD PF02109.16 KOO25020.1 - 0.07 13.4 1.7 7.8 6.9 0.3 2.3 2 0 0 2 2 2 0 DAD family CD20 PF04103.15 KOO25020.1 - 0.1 12.7 10.0 0.15 12.1 6.2 2.2 2 1 0 2 2 2 0 CD20-like family Bys1 PF04681.12 KOO25020.1 - 0.23 11.4 0.1 0.38 10.7 0.1 1.3 1 0 0 1 1 1 0 Blastomyces yeast-phase-specific protein PAS_9 PF13426.7 KOO25021.1 - 1.3e-07 31.8 0.0 2.9e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 KOO25021.1 - 3.8e-05 23.7 0.0 6.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 KOO25021.1 - 0.0014 18.9 0.0 0.0023 18.2 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 KOO25021.1 - 0.017 15.4 0.0 0.026 14.8 0.0 1.3 1 0 0 1 1 1 0 PAS fold PAS_8 PF13188.7 KOO25021.1 - 0.034 14.2 0.0 0.083 12.9 0.0 1.7 1 1 1 2 2 2 0 PAS domain MEKHLA PF08670.11 KOO25021.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 MEKHLA domain EF-hand_1 PF00036.32 KOO25022.1 - 3.6e-14 51.2 7.0 6.7e-07 28.4 0.1 2.6 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO25022.1 - 1.4e-13 51.1 1.1 2.4e-13 50.3 1.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO25022.1 - 1.1e-12 46.8 1.9 2.2e-06 27.1 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO25022.1 - 1.8e-11 43.0 0.9 2.8e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO25022.1 - 1.2e-09 37.8 0.4 1.2e-09 37.8 0.4 2.1 3 0 0 3 3 3 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO25022.1 - 9.4e-05 22.7 0.2 0.00016 22.0 0.1 1.4 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO25022.1 - 0.012 15.5 0.2 0.026 14.4 0.2 1.6 1 0 0 1 1 1 0 EF hand EF-hand_11 PF08976.11 KOO25022.1 - 0.012 16.4 0.0 0.064 14.1 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 KOO25022.1 - 0.032 14.2 0.5 1.4 8.9 0.1 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand PMBR PF09373.10 KOO25022.1 - 0.054 13.7 0.0 1.6 9.0 0.0 2.9 3 0 0 3 3 3 0 Pseudomurein-binding repeat Actin PF00022.19 KOO25023.1 - 1.1e-49 169.1 0.0 1e-44 152.8 0.0 3.1 1 1 1 2 2 2 2 Actin FtsA PF14450.6 KOO25023.1 - 0.037 14.4 0.0 0.098 13.1 0.0 1.8 1 0 0 1 1 1 0 Cell division protein FtsA DUF2505 PF10698.9 KOO25024.1 - 5.5e-08 33.1 0.0 5.5e-08 33.1 0.0 2.9 3 2 1 4 4 4 1 Protein of unknown function (DUF2505) LMBR1 PF04791.16 KOO25024.1 - 2.8 6.7 4.0 4.5 6.1 4.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Pkinase PF00069.25 KOO25025.1 - 8.6e-13 48.3 0.0 2.8e-12 46.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25025.1 - 0.0012 18.2 0.0 0.0035 16.7 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase LRR_4 PF12799.7 KOO25026.1 - 1.3e-12 47.7 0.6 3.1e-07 30.6 0.1 2.1 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO25026.1 - 5.5e-12 45.3 1.5 6.9e-07 28.9 0.2 1.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 KOO25026.1 - 0.0062 16.9 0.0 0.63 10.8 0.1 2.9 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_9 PF14580.6 KOO25026.1 - 0.019 14.4 0.1 0.021 14.3 0.1 1.0 1 0 0 1 1 1 0 Leucine-rich repeat SLD5_C PF16922.5 KOO25027.1 - 3.5e-07 30.3 0.0 7.6e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Gryzun PF07919.12 KOO25027.1 - 0.019 13.7 0.2 2.3 6.9 0.0 2.0 1 1 1 2 2 2 0 Gryzun, putative trafficking through Golgi P4Ha_N PF08336.11 KOO25027.1 - 0.025 14.6 3.0 0.26 11.3 1.3 2.2 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region PKcGMP_CC PF16808.5 KOO25027.1 - 0.052 13.4 2.6 0.13 12.1 2.6 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TEX13 PF15186.6 KOO25027.1 - 0.089 12.5 0.5 0.15 11.8 0.5 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family BAR_2 PF10455.9 KOO25027.1 - 0.093 11.8 0.8 0.13 11.4 0.8 1.1 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Sld5 PF05916.11 KOO25027.1 - 0.11 13.0 2.5 0.32 11.5 2.5 1.8 1 1 0 1 1 1 0 GINS complex protein Y2_Tnp PF04986.13 KOO25027.1 - 0.11 12.5 0.8 0.16 12.0 0.8 1.2 1 0 0 1 1 1 0 Putative transposase Zein-binding PF04576.15 KOO25027.1 - 0.59 10.5 5.8 0.63 10.4 0.3 2.7 2 1 1 3 3 3 0 Zein-binding Methyltransf_28 PF02636.17 KOO25028.1 - 4e-15 56.2 0.0 7.1e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RVT_2 PF07727.14 KOO25028.1 - 7.5e-07 29.0 0.0 1.3e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Filamin PF00630.19 KOO25030.1 - 6.9e-46 155.3 0.0 4e-16 59.7 0.0 6.4 6 0 0 6 6 6 6 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO25030.1 - 4e-10 39.9 1.7 0.0062 16.8 0.0 4.8 5 0 0 5 5 5 3 Invasin, domain 3 Neurexophilin PF06312.12 KOO25030.1 - 0.016 14.7 0.1 0.38 10.2 0.0 2.5 3 0 0 3 3 3 0 Neurexophilin SH3_3 PF08239.11 KOO25030.1 - 0.024 14.9 0.0 0.057 13.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain Hint PF01079.20 KOO25031.1 - 4.1e-15 55.9 0.1 4.5e-15 55.7 0.1 1.0 1 0 0 1 1 1 1 Hint module Laminin_G_3 PF13385.6 KOO25033.1 - 0.00014 22.0 0.1 0.00049 20.3 0.1 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily UPF0176_N PF17773.1 KOO25034.1 - 2.9e-15 56.4 0.0 4.4e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese PF00581.20 KOO25034.1 - 7.1e-07 29.7 0.0 1.3e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Rhodanese_C PF12368.8 KOO25034.1 - 0.00082 19.7 7.8 0.00082 19.7 7.8 1.8 2 0 0 2 2 2 1 Rhodanase C-terminal Thioredoxin PF00085.20 KOO25035.1 - 4.8e-14 52.2 0.0 1.1e-09 38.2 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 KOO25035.1 - 2.2e-08 34.2 0.0 0.0059 16.5 0.0 3.6 4 0 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 KOO25035.1 - 0.01 16.3 0.0 1.8 9.0 0.0 3.0 2 1 0 2 2 2 0 Thioredoxin-like domain YabA PF06156.13 KOO25035.1 - 0.063 13.9 0.7 0.11 13.2 0.7 1.3 1 0 0 1 1 1 0 Initiation control protein YabA OST3_OST6 PF04756.13 KOO25035.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family HALZ PF02183.18 KOO25035.1 - 0.24 11.6 1.9 1 9.6 2.0 2.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper ZapB PF06005.12 KOO25035.1 - 0.5 10.8 4.5 1.1 9.8 4.5 1.5 1 0 0 1 1 1 0 Cell division protein ZapB Pkinase PF00069.25 KOO25036.1 - 6.9e-73 245.2 0.0 7.9e-73 245.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25036.1 - 3.9e-44 150.9 0.0 4.8e-44 150.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO25036.1 - 2.4e-06 27.1 0.0 0.00015 21.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KOO25036.1 - 0.00059 19.2 0.2 0.00093 18.6 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOO25036.1 - 0.0013 17.8 0.1 0.0021 17.1 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOO25036.1 - 0.005 16.8 5.5 0.025 14.5 0.7 2.5 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 KOO25036.1 - 0.019 14.5 0.0 0.048 13.2 0.0 1.5 1 1 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 KOO25036.1 - 0.11 11.5 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Ribosomal_L32p PF01783.23 KOO25037.1 - 0.025 14.8 4.1 0.036 14.3 4.1 1.2 1 0 0 1 1 1 0 Ribosomal L32p protein family FAM199X PF15814.5 KOO25037.1 - 0.12 11.4 5.5 0.15 11.1 5.5 1.0 1 0 0 1 1 1 0 Protein family FAM199X STIL_N PF15253.6 KOO25038.1 - 2.1e-25 89.5 0.3 6.1e-25 88.0 0.0 1.8 3 0 0 3 3 3 1 SCL-interrupting locus protein N-terminus UPRTase PF14681.6 KOO25039.1 - 6.6e-54 182.5 0.1 7.9e-54 182.3 0.1 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DivIC PF04977.15 KOO25040.1 - 0.027 14.2 0.3 0.15 11.9 0.0 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF4200 PF13863.6 KOO25040.1 - 0.11 12.9 12.4 1.4 9.4 2.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) COG5 PF10392.9 KOO25040.1 - 0.17 12.1 2.9 5.5 7.2 0.1 2.7 2 1 1 3 3 3 0 Golgi transport complex subunit 5 YabA PF06156.13 KOO25040.1 - 0.97 10.1 3.6 4.4 8.0 0.0 2.9 2 1 0 2 2 2 0 Initiation control protein YabA OHCU_decarbox PF09349.10 KOO25041.1 - 1.1e-42 146.1 1.5 1.4e-42 145.8 1.5 1.1 1 0 0 1 1 1 1 OHCU decarboxylase Transthyretin PF00576.21 KOO25041.1 - 4.6e-32 111.0 0.0 8.1e-32 110.2 0.0 1.4 1 0 0 1 1 1 1 HIUase/Transthyretin family ABC_membrane PF00664.23 KOO25043.1 - 4.4e-46 157.7 5.8 9.1e-46 156.7 5.8 1.5 1 0 0 1 1 1 1 ABC transporter transmembrane region C1_2 PF03107.16 KOO25043.1 - 3.8e-07 30.3 11.1 9.4e-07 29.1 9.0 2.2 2 0 0 2 2 2 1 C1 domain ZZ PF00569.17 KOO25043.1 - 0.0011 18.7 6.4 0.0026 17.5 6.4 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type ABC_membrane_3 PF13748.6 KOO25043.1 - 0.37 10.0 3.3 0.17 11.1 0.1 2.1 2 0 0 2 2 2 0 ABC transporter transmembrane region Myb_DNA-binding PF00249.31 KOO25044.1 - 6.2e-32 109.5 3.3 7.9e-16 58.0 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO25044.1 - 3.1e-22 78.6 0.4 2.7e-15 56.3 0.1 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO25044.1 - 1.8e-05 24.6 6.9 5.8e-05 22.9 0.1 3.1 3 0 0 3 3 3 1 Myb DNA-binding like SLIDE PF09111.10 KOO25044.1 - 4.2e-05 23.5 0.0 0.16 12.0 0.0 2.4 1 1 1 2 2 2 2 SLIDE Rap1_C PF11626.8 KOO25044.1 - 0.013 15.6 0.0 1.2 9.3 0.0 2.8 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain SANT_DAMP1_like PF16282.5 KOO25044.1 - 0.05 13.8 0.1 11 6.3 0.0 2.3 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 MADF_DNA_bdg PF10545.9 KOO25044.1 - 0.38 11.1 1.8 6.6 7.1 0.7 2.5 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Nop14 PF04147.12 KOO25044.1 - 9.6 4.3 15.7 13 3.9 15.7 1.1 1 0 0 1 1 1 0 Nop14-like family Peptidase_M14 PF00246.24 KOO25045.1 - 4.6e-40 138.2 0.0 7.8e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Pre-PUA PF17832.1 KOO25046.1 - 3.3e-17 62.9 0.0 5.9e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Pre-PUA-like domain SUI1 PF01253.22 KOO25046.1 - 1.2e-11 44.9 0.0 5.8e-11 42.8 0.0 2.1 2 0 0 2 2 2 1 Translation initiation factor SUI1 Kin17_mid PF10357.9 KOO25046.1 - 0.0085 16.0 0.1 0.017 15.0 0.1 1.4 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein PUA PF01472.20 KOO25046.1 - 0.01 15.8 0.2 0.023 14.7 0.2 1.6 1 0 0 1 1 1 0 PUA domain Thioredoxin PF00085.20 KOO25047.1 - 1.5e-19 69.9 0.0 2e-19 69.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KOO25047.1 - 0.0006 20.1 0.0 0.0014 18.9 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.6 KOO25047.1 - 0.0026 17.5 0.0 0.0033 17.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 KOO25047.1 - 0.0048 16.8 0.0 0.0057 16.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOO25047.1 - 0.0051 16.5 0.0 0.0074 16.0 0.0 1.4 1 1 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 KOO25047.1 - 0.0097 16.4 0.0 0.054 13.9 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Glutaredoxin PF00462.24 KOO25047.1 - 0.17 12.1 0.0 1.8 8.8 0.0 2.2 2 0 0 2 2 2 0 Glutaredoxin COPI_assoc PF08507.10 KOO25048.1 - 1e-07 32.1 8.4 1.2e-07 31.8 8.4 1.1 1 0 0 1 1 1 1 COPI associated protein Cg6151-P PF10233.9 KOO25048.1 - 0.0021 18.3 3.9 0.0041 17.4 3.8 1.6 1 1 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Myosin_head PF00063.21 KOO25051.1 - 1.1e-191 638.5 0.0 1.5e-191 638.1 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 KOO25051.1 - 0.44 10.9 0.0 0.44 10.9 0.0 3.2 3 1 0 3 3 3 0 AAA ATPase domain ABC_tran PF00005.27 KOO25052.1 - 1.8e-18 67.3 0.0 2.3e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOO25052.1 - 2.1e-06 27.3 0.1 0.042 13.3 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOO25052.1 - 0.00026 20.9 0.1 0.012 15.5 0.1 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOO25052.1 - 0.00082 19.1 0.1 0.0019 17.9 0.0 1.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO25052.1 - 0.03 14.6 0.1 1.5 9.1 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 KOO25052.1 - 0.032 13.8 0.0 0.063 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO25052.1 - 0.035 14.3 0.0 0.055 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KOO25052.1 - 0.035 14.0 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 KOO25052.1 - 0.049 14.1 0.0 0.085 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 KOO25052.1 - 0.062 11.9 0.0 0.082 11.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 KOO25052.1 - 0.082 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_18 PF13238.6 KOO25052.1 - 0.083 13.4 0.0 0.18 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain MORN PF02493.20 KOO25053.1 - 1.3e-42 141.2 49.6 9.5e-06 25.2 0.2 8.9 9 0 0 9 9 9 8 MORN repeat DUF448 PF04296.13 KOO25053.1 - 2.1 8.3 3.6 16 5.4 0.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF448) Thiolase_N PF00108.23 KOO25054.1 - 2e-75 253.5 2.2 2e-75 253.5 2.2 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOO25054.1 - 2.6e-47 159.5 1.7 2.6e-47 159.5 1.7 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain Dodecin PF07311.12 KOO25054.1 - 0.042 14.1 0.0 0.18 12.1 0.0 2.0 1 0 0 1 1 1 0 Dodecin LRR_4 PF12799.7 KOO25055.1 - 1.3e-14 54.1 8.0 7.7e-09 35.7 0.4 3.2 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO25055.1 - 1.4e-12 47.4 0.0 1.9e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 KOO25055.1 - 1.8e-09 37.2 5.7 1.7e-06 27.7 1.5 2.5 1 1 0 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 KOO25055.1 - 9.5e-05 22.2 2.2 0.54 10.4 0.0 3.8 3 0 0 3 3 3 1 Leucine Rich repeat LRR_1 PF00560.33 KOO25055.1 - 0.012 16.1 4.2 2 9.3 0.2 3.9 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_2 PF07723.13 KOO25055.1 - 0.043 14.5 0.0 5.2 7.9 0.0 2.7 2 0 0 2 2 2 0 Leucine Rich Repeat NnrU PF07298.11 KOO25056.1 - 2.3e-06 27.3 4.4 8.7e-05 22.1 1.3 2.2 2 0 0 2 2 2 2 NnrU protein cNMP_binding PF00027.29 KOO25057.1 - 7.8e-15 54.7 1.2 2.6e-06 27.4 0.4 3.5 2 2 0 2 2 2 2 Cyclic nucleotide-binding domain Mito_carr PF00153.27 KOO25058.1 - 2.4e-06 27.4 0.0 3.5e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial carrier protein Mnd1 PF03962.15 KOO25059.1 - 4.7e-15 55.6 0.0 8.9e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Mnd1 HTH domain LZ3wCH PF18517.1 KOO25059.1 - 6.5e-08 32.6 0.1 6.5e-08 32.6 0.1 2.4 3 0 0 3 3 3 1 Leucine zipper with capping helix domain E2F_CC-MB PF16421.5 KOO25059.1 - 0.068 13.5 0.4 0.068 13.5 0.4 1.9 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain RHH_1 PF01402.21 KOO25059.1 - 0.58 10.2 4.5 1.2 9.2 0.3 3.2 3 1 0 3 3 3 0 Ribbon-helix-helix protein, copG family ATP-synt PF00231.19 KOO25060.1 - 6.7e-87 291.8 3.7 7.6e-87 291.6 3.7 1.0 1 0 0 1 1 1 1 ATP synthase Ntox1 PF15500.6 KOO25060.1 - 0.34 11.3 4.3 5.1 7.5 1.1 2.6 2 0 0 2 2 2 0 Putative RNase-like toxin, toxin_1 Rad1 PF02144.16 KOO25061.1 - 9.4e-28 97.0 0.0 1.3e-27 96.6 0.0 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 DnaJ PF00226.31 KOO25062.1 - 6e-20 71.1 0.0 1.1e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain TPT PF03151.16 KOO25063.1 - 5.7e-14 52.1 18.9 6.7e-14 51.9 18.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO25063.1 - 1.8e-05 24.9 35.1 0.00014 22.0 18.5 2.1 2 0 0 2 2 2 2 EamA-like transporter family Suppressor_P21 PF11479.8 KOO25063.1 - 0.2 11.9 0.7 0.98 9.6 0.0 2.3 2 1 0 2 2 2 0 RNA silencing suppressor P21 C-terminal domain FHA PF00498.26 KOO25064.1 - 6e-10 39.3 0.0 2.6e-09 37.3 0.0 2.0 2 0 0 2 2 2 1 FHA domain SAP PF02037.27 KOO25064.1 - 6.4e-05 22.6 0.2 0.00018 21.1 0.2 1.8 1 0 0 1 1 1 1 SAP domain LRR_6 PF13516.6 KOO25065.1 - 7.6e-31 103.5 49.9 0.0013 18.6 0.4 13.3 13 0 0 13 13 13 9 Leucine Rich repeat EF-hand_1 PF00036.32 KOO25065.1 - 4.3e-11 41.5 0.2 2.8e-05 23.3 0.1 2.8 2 0 0 2 2 2 2 EF hand LRR_1 PF00560.33 KOO25065.1 - 3.4e-09 36.0 6.0 64 4.7 0.0 10.9 12 0 0 12 12 10 0 Leucine Rich Repeat EF-hand_7 PF13499.6 KOO25065.1 - 2.8e-08 34.1 0.1 6e-08 33.0 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO25065.1 - 1.1e-07 31.2 0.0 0.033 14.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain LRR_4 PF12799.7 KOO25065.1 - 3.9e-07 30.3 16.0 2.8 8.5 0.0 9.5 8 1 1 9 9 9 1 Leucine Rich repeats (2 copies) PDZ_2 PF13180.6 KOO25065.1 - 1e-06 29.0 0.0 2.3e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO25065.1 - 3.9e-06 26.6 0.3 1.4e-05 24.8 0.3 2.0 1 0 0 1 1 1 1 PDZ domain EF-hand_5 PF13202.6 KOO25065.1 - 1.8e-05 24.0 0.2 0.097 12.2 0.1 2.6 2 0 0 2 2 2 2 EF hand LRR_8 PF13855.6 KOO25065.1 - 0.00027 20.6 21.3 14 5.6 0.1 10.2 10 1 0 10 10 10 0 Leucine rich repeat EF-hand_8 PF13833.6 KOO25065.1 - 0.00098 18.9 0.4 0.0035 17.1 0.4 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO25065.1 - 0.0042 17.4 0.1 0.0092 16.3 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO25065.1 - 0.0084 16.1 0.5 0.033 14.2 0.2 2.0 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO25065.1 - 0.23 11.7 6.1 0.056 13.6 1.4 2.6 2 0 0 2 2 2 0 Dockerin type I domain Parecho_VpG PF06344.11 KOO25065.1 - 0.3 11.8 11.7 13 6.7 0.1 4.7 5 0 0 5 5 4 0 Parechovirus Genome-linked protein Big_9 PF17963.1 KOO25066.1 - 0.023 15.4 9.2 2.1 9.1 0.3 5.0 4 1 0 4 4 4 0 Bacterial Ig domain Cadherin_4 PF17803.1 KOO25066.1 - 0.046 14.4 9.6 5.9 7.6 0.1 4.3 4 0 0 4 4 4 0 Bacterial cadherin-like domain Laminin_G_3 PF13385.6 KOO25066.1 - 0.11 12.6 0.1 6.3 6.9 0.0 3.3 3 0 0 3 3 3 0 Concanavalin A-like lectin/glucanases superfamily Invasin_D3 PF09134.10 KOO25066.1 - 0.19 12.0 0.2 5.5 7.4 0.0 2.5 2 0 0 2 2 2 0 Invasin, domain 3 Abhydrolase_6 PF12697.7 KOO25067.1 - 7.2e-17 62.7 2.8 8.4e-17 62.5 2.8 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO25067.1 - 8.1e-08 31.8 0.0 1e-07 31.5 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO25067.1 - 2.8e-07 30.4 0.1 3.2e-07 30.3 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 KOO25067.1 - 0.067 13.0 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Lipase_2 PF01674.18 KOO25067.1 - 0.2 11.2 0.0 0.24 10.9 0.0 1.1 1 0 0 1 1 1 0 Lipase (class 2) PH PF00169.29 KOO25068.1 - 0.00018 22.0 0.0 0.00046 20.7 0.0 1.7 2 0 0 2 2 2 1 PH domain BAR PF03114.18 KOO25068.1 - 0.035 13.8 1.8 0.051 13.2 0.6 1.8 2 0 0 2 2 2 0 BAR domain FGE-sulfatase PF03781.16 KOO25069.1 - 7.4e-62 209.3 3.9 1.1e-61 208.7 3.9 1.2 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Helicase_C PF00271.31 KOO25070.1 - 3.3e-09 37.0 0.0 5.6e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Trypsin_2 PF13365.6 KOO25071.1 - 1.1e-25 91.3 1.0 5.7e-22 79.2 0.1 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_1 PF12812.7 KOO25071.1 - 1.3e-22 79.6 0.0 5.8e-19 67.9 0.0 3.1 3 0 0 3 3 3 2 PDZ-like domain PDZ_6 PF17820.1 KOO25071.1 - 8.1e-11 41.6 0.1 1.7e-05 24.6 0.0 3.9 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 KOO25071.1 - 1.1e-07 32.1 0.0 0.025 14.9 0.0 3.6 4 0 0 4 4 4 2 PDZ domain Trypsin PF00089.26 KOO25071.1 - 1.6e-05 24.8 0.0 0.00033 20.5 0.0 2.3 2 0 0 2 2 2 1 Trypsin PDZ PF00595.24 KOO25071.1 - 0.00023 21.5 0.0 0.073 13.4 0.0 3.2 3 0 0 3 3 3 1 PDZ domain Peptidase_S46 PF10459.9 KOO25071.1 - 0.011 14.4 0.2 0.018 13.7 0.2 1.2 1 0 0 1 1 1 0 Peptidase S46 Peptidase_S7 PF00949.21 KOO25071.1 - 0.094 12.5 0.3 0.2 11.5 0.3 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease DUF31 PF01732.16 KOO25071.1 - 0.35 10.3 2.2 0.27 10.7 0.9 1.4 2 0 0 2 2 2 0 Putative peptidase (DUF31) HSCB_C PF07743.13 KOO25072.1 - 1.2e-13 51.4 4.1 1.3e-13 51.2 4.1 1.0 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain PolyA_pol_RNAbd PF12627.7 KOO25072.1 - 0.015 15.0 0.3 0.043 13.6 0.1 1.7 2 0 0 2 2 2 0 Probable RNA and SrmB- binding site of polymerase A H-kinase_dim PF02895.14 KOO25072.1 - 0.31 11.5 1.7 0.65 10.4 1.7 1.7 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain DUF349 PF03993.12 KOO25072.1 - 0.6 10.4 3.5 1.2 9.5 1.0 2.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) Herpes_UL25 PF01499.16 KOO25073.1 - 0.71 8.3 5.4 0.99 7.8 5.4 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family LPP PF04728.13 KOO25076.1 - 0.33 11.4 0.2 0.33 11.4 0.2 2.5 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Isochorismatase PF00857.20 KOO25078.1 - 5.8e-29 101.5 0.6 8.2e-28 97.7 0.6 2.1 1 1 0 1 1 1 1 Isochorismatase family EF-hand_1 PF00036.32 KOO25078.1 - 7e-12 44.0 0.2 3.2e-05 23.2 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO25078.1 - 9.4e-11 40.7 0.1 6.8e-05 22.5 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO25078.1 - 9.7e-11 40.7 0.1 0.00054 19.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO25078.1 - 6.1e-10 39.4 0.2 1.1e-09 38.6 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO25078.1 - 1.7e-07 31.0 0.5 7.3e-07 28.9 0.2 2.0 1 1 1 2 2 2 2 EF-hand domain pair polyprenyl_synt PF00348.17 KOO25079.1 - 3.7e-64 216.3 0.1 4.5e-64 216.0 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 KOO25079.1 - 0.00024 20.8 0.4 0.00033 20.3 0.4 1.1 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Bromodomain PF00439.25 KOO25080.1 - 8e-17 61.1 0.1 1.6e-16 60.1 0.1 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_10 PF13673.7 KOO25080.1 - 9.6e-12 45.0 0.2 1.6e-11 44.3 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO25080.1 - 3.9e-11 43.2 0.0 7.6e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO25080.1 - 1.9e-07 31.4 0.1 3.8e-07 30.4 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RestrictionSfiI PF11487.8 KOO25080.1 - 0.03 14.2 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 Type II restriction enzyme SfiI Acetyltransf_9 PF13527.7 KOO25080.1 - 0.037 14.1 0.0 0.098 12.7 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO25080.1 - 0.044 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein PP2C_2 PF13672.6 KOO25081.1 - 0.023 14.3 1.8 0.043 13.4 1.8 1.5 1 0 0 1 1 1 0 Protein phosphatase 2C Ribosomal_60s PF00428.19 KOO25081.1 - 0.03 14.9 1.8 0.066 13.8 1.8 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein MTHFR PF02219.17 KOO25082.1 - 4.1e-35 121.5 0.0 6e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase ApbA_C PF08546.11 KOO25083.1 - 1.5e-13 51.0 0.0 2.1e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DUF5597 PF18120.1 KOO25083.1 - 0.056 13.6 0.0 0.066 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5597) Orexin PF02072.15 KOO25083.1 - 0.1 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Prepro-orexin EF-hand_1 PF00036.32 KOO25084.1 - 5e-24 82.0 19.1 7.5e-05 22.0 0.4 6.6 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO25084.1 - 8.9e-22 77.3 7.6 2.7e-06 27.8 0.0 5.1 3 1 3 6 6 6 6 EF-hand domain pair EF-hand_6 PF13405.6 KOO25084.1 - 9.4e-21 71.9 14.4 0.00011 21.8 0.4 6.6 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.6 KOO25084.1 - 5e-09 35.9 13.1 0.0078 16.0 0.0 5.2 5 1 1 6 6 6 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO25084.1 - 1.3e-06 27.7 18.4 0.015 14.7 0.8 6.3 6 0 0 6 6 6 3 EF hand EF-hand_4 PF12763.7 KOO25084.1 - 0.62 10.0 6.4 1.5 8.9 0.1 3.3 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand Peptidase_M14 PF00246.24 KOO25085.1 - 8.2e-23 81.6 0.0 1.9e-22 80.4 0.0 1.5 1 1 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 KOO25085.1 - 0.0001 21.5 0.0 0.00016 20.9 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF4231 PF14015.6 KOO25086.1 - 0.012 16.1 1.0 0.012 16.1 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Otopetrin PF03189.13 KOO25086.1 - 0.041 12.7 0.0 0.082 11.7 0.0 1.4 1 0 0 1 1 1 0 Otopetrin IF-2B PF01008.17 KOO25086.1 - 0.1 11.8 0.0 0.24 10.6 0.0 1.6 1 0 0 1 1 1 0 Initiation factor 2 subunit family LSDAT_euk PF18139.1 KOO25087.1 - 0.052 12.9 0.1 0.11 11.9 0.0 1.5 1 1 0 1 1 1 0 SLOG in TRPM RNase_PH PF01138.21 KOO25088.1 - 1.4e-10 41.8 0.6 1.9e-10 41.3 0.1 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 VirB8 PF04335.13 KOO25088.1 - 0.047 13.5 0.1 0.064 13.1 0.1 1.3 1 0 0 1 1 1 0 VirB8 protein CBFD_NFYB_HMF PF00808.23 KOO25089.1 - 5.9e-05 23.3 0.5 0.0001 22.5 0.5 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CBFD_NFYB_HMF PF00808.23 KOO25090.1 - 1.3e-05 25.3 0.0 2.1e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOO25090.1 - 0.054 13.8 0.0 0.079 13.3 0.0 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Peptidase_C1 PF00112.23 KOO25093.1 - 4.4e-18 66.2 2.9 5.8e-18 65.8 2.9 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1 PF00112.23 KOO25094.1 - 8.1e-27 94.7 4.0 1.1e-26 94.4 4.0 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KOO25094.1 - 0.0037 16.1 1.4 0.0045 15.8 1.4 1.1 1 0 0 1 1 1 1 Peptidase C1-like family Thioredoxin PF00085.20 KOO25095.1 - 3.5e-26 91.2 0.0 5.9e-21 74.4 0.0 4.2 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 KOO25095.1 - 1.1e-14 54.8 0.0 1.8e-06 28.0 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 KOO25095.1 - 7.3e-06 25.5 0.0 0.0043 16.5 0.0 2.9 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 KOO25095.1 - 0.0014 18.9 0.0 0.89 9.9 0.0 3.3 3 0 0 3 3 3 1 Thioredoxin-like Thioredoxin_2 PF13098.6 KOO25095.1 - 0.0024 18.3 3.6 1.3 9.5 0.0 4.2 4 1 0 4 4 4 2 Thioredoxin-like domain Thioredoxin_3 PF13192.6 KOO25095.1 - 0.005 16.9 0.0 0.34 11.0 0.0 3.1 3 0 0 3 3 3 1 Thioredoxin domain HyaE PF07449.11 KOO25095.1 - 0.0074 16.2 0.0 0.064 13.2 0.0 2.6 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.21 KOO25095.1 - 0.039 13.9 0.0 0.15 12.0 0.0 2.0 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_7 PF13899.6 KOO25095.1 - 0.1 12.8 0.0 0.37 11.0 0.0 2.0 1 0 0 1 1 1 0 Thioredoxin-like Lzipper-MIP1 PF14389.6 KOO25097.1 - 0.0019 18.4 7.1 0.018 15.3 2.5 2.7 2 0 0 2 2 2 1 Leucine-zipper of ternary complex factor MIP1 CENP-F_leu_zip PF10473.9 KOO25097.1 - 0.0055 16.7 12.0 0.0069 16.4 4.9 3.1 3 1 0 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.19 KOO25097.1 - 0.0082 16.0 17.4 0.011 15.5 17.4 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF2470 PF10615.9 KOO25097.1 - 0.1 13.2 0.9 2.7 8.7 0.9 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2470) TACC_C PF05010.14 KOO25097.1 - 0.18 11.5 4.4 0.34 10.7 4.4 1.4 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal IFP_35_N PF07334.13 KOO25097.1 - 0.2 11.7 1.0 4.2 7.5 0.1 2.4 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Fungal_TACC PF12709.7 KOO25097.1 - 0.22 12.0 2.9 9.2 6.8 0.1 3.1 3 0 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Macoilin PF09726.9 KOO25097.1 - 0.6 8.6 7.2 0.79 8.2 7.2 1.3 1 0 0 1 1 1 0 Macoilin family DUF1640 PF07798.11 KOO25097.1 - 1.9 8.5 7.9 2 8.5 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) Fez1 PF06818.15 KOO25097.1 - 2 8.8 13.2 29 5.0 13.2 2.3 1 1 0 1 1 1 0 Fez1 DivIC PF04977.15 KOO25097.1 - 2.5 8.0 8.4 6.7 6.6 0.5 3.2 3 0 0 3 3 3 0 Septum formation initiator DUF1690 PF07956.11 KOO25097.1 - 3 8.3 7.5 3.9 7.9 5.7 2.0 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) Aldo_ket_red PF00248.21 KOO25098.1 - 1.1e-41 143.0 0.0 1.5e-41 142.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Androgen_recep PF02166.16 KOO25098.1 - 0.79 8.5 8.3 0.021 13.7 1.2 1.8 2 0 0 2 2 2 0 Androgen receptor Bestrophin PF01062.21 KOO25099.1 - 2.4e-27 96.1 2.1 3.8e-27 95.5 2.1 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Exostosin PF03016.15 KOO25100.1 - 6.3e-26 91.3 0.1 3e-22 79.2 0.0 2.1 1 1 1 2 2 2 2 Exostosin family EF-hand_7 PF13499.6 KOO25101.1 - 2.4e-14 53.6 0.5 1.8e-12 47.5 0.5 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO25101.1 - 1.8e-12 45.8 0.5 3.2e-05 23.2 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO25101.1 - 8.8e-12 44.0 0.7 2.5e-06 27.0 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO25101.1 - 4.2e-11 42.5 1.2 2.4e-08 33.7 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO25101.1 - 6.7e-07 28.5 0.6 0.0049 16.3 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO25101.1 - 0.04 14.2 0.0 3.4 8.1 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain EF-hand_14 PF17959.1 KOO25101.1 - 0.057 13.8 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO25101.1 - 0.18 12.1 0.0 0.4 11.0 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Atg14 PF10186.9 KOO25102.1 - 0.0063 15.6 0.6 0.0066 15.6 0.6 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Bud13 PF09736.9 KOO25102.1 - 0.049 14.0 1.0 0.066 13.6 1.0 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex GvpG PF05120.12 KOO25102.1 - 0.11 12.6 4.6 0.19 11.8 4.6 1.4 1 0 0 1 1 1 0 Gas vesicle protein G XhlA PF10779.9 KOO25102.1 - 0.31 11.3 3.8 0.67 10.2 0.3 2.3 2 0 0 2 2 2 0 Haemolysin XhlA Nnf1 PF03980.14 KOO25102.1 - 0.42 11.0 6.3 14 6.1 6.3 2.1 1 1 0 1 1 1 0 Nnf1 Csm1_N PF18504.1 KOO25102.1 - 1.3 9.4 6.3 6.7 7.1 0.4 2.2 1 1 1 2 2 2 0 Csm1 N-terminal domain DUF2599 PF10783.9 KOO25102.1 - 4.3 8.0 7.3 0.97 10.1 0.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2599) Spc24 PF08286.11 KOO25102.1 - 5.8 7.2 5.8 1.7 9.0 0.9 2.0 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Hydrolase_like PF13242.6 KOO25103.1 - 1.2e-13 51.0 2.3 8e-12 45.1 0.0 3.5 4 1 0 4 4 4 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 KOO25103.1 - 5.2e-11 42.5 0.0 2.9e-10 40.2 0.0 2.3 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase ERGIC_N PF13850.6 KOO25103.1 - 0.12 12.8 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) LRR_8 PF13855.6 KOO25104.1 - 4.2e-11 42.5 10.2 1.5e-07 31.1 1.0 8.4 7 3 0 8 8 8 2 Leucine rich repeat LRR_4 PF12799.7 KOO25104.1 - 6.2e-11 42.4 42.4 0.0005 20.4 1.7 9.9 9 2 2 11 11 11 5 Leucine Rich repeats (2 copies) Roc PF08477.13 KOO25104.1 - 6.5e-10 39.3 0.0 2.5e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SH3_3 PF08239.11 KOO25104.1 - 3.3e-08 33.7 0.1 1.8 8.9 0.0 5.7 5 0 0 5 5 5 1 Bacterial SH3 domain LRR_6 PF13516.6 KOO25104.1 - 9.9e-07 28.3 4.4 0.00031 20.6 0.2 13.9 18 0 0 18 18 18 3 Leucine Rich repeat Ras PF00071.22 KOO25104.1 - 1.4e-05 24.8 0.0 0.00018 21.1 0.0 2.3 2 0 0 2 2 2 1 Ras family COR PF16095.5 KOO25104.1 - 0.0016 18.3 0.0 0.0038 17.1 0.0 1.6 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain ART PF01129.18 KOO25104.1 - 0.002 17.5 0.0 0.34 10.2 0.0 2.6 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase AAA_19 PF13245.6 KOO25104.1 - 0.016 15.6 1.9 0.048 14.0 0.1 2.8 3 0 0 3 3 2 0 AAA domain LRR_9 PF14580.6 KOO25104.1 - 0.018 14.6 2.2 0.087 12.3 1.1 2.5 1 1 0 1 1 1 0 Leucine-rich repeat AAA PF00004.29 KOO25104.1 - 0.081 13.4 0.0 0.67 10.4 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 KOO25104.1 - 0.086 12.0 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit RBR PF17208.3 KOO25104.1 - 0.26 12.0 1.9 1.7 9.4 1.9 2.4 1 0 0 1 1 1 0 RNA binding Region LRR_1 PF00560.33 KOO25104.1 - 3.2 8.7 23.6 18 6.4 0.0 10.1 15 0 0 15 15 10 0 Leucine Rich Repeat Phospholip_B PF04916.13 KOO25105.1 - 2.3e-114 382.9 0.0 2.7e-114 382.7 0.0 1.0 1 0 0 1 1 1 1 Phospholipase B Nucleotid_trans PF03407.16 KOO25106.1 - 1.4e-36 126.5 0.0 2e-36 126.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase O-FucT PF10250.9 KOO25106.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase FPP PF05911.11 KOO25107.1 - 0.0015 16.8 1.1 0.0018 16.5 1.1 1.0 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil CLZ PF16526.5 KOO25107.1 - 0.0017 18.6 1.6 0.0041 17.4 0.7 1.8 1 1 1 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Cast PF10174.9 KOO25107.1 - 0.0093 14.3 1.0 0.01 14.2 1.0 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone XhlA PF10779.9 KOO25107.1 - 0.0094 16.1 2.7 0.037 14.2 1.6 2.0 1 1 1 2 2 2 1 Haemolysin XhlA Use1 PF09753.9 KOO25107.1 - 0.012 15.4 0.4 0.023 14.4 0.4 1.5 1 1 1 2 2 2 0 Membrane fusion protein Use1 MCU PF04678.13 KOO25107.1 - 0.013 15.6 0.1 0.014 15.5 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter GAS PF13851.6 KOO25107.1 - 0.025 14.0 1.1 0.027 13.8 1.1 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF2207 PF09972.9 KOO25107.1 - 0.027 13.3 0.1 0.03 13.1 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SNARE PF05739.19 KOO25107.1 - 0.035 14.1 0.1 0.11 12.6 0.0 1.8 2 0 0 2 2 2 0 SNARE domain THOC7 PF05615.13 KOO25107.1 - 0.062 13.6 0.7 0.072 13.4 0.7 1.1 1 0 0 1 1 1 0 Tho complex subunit 7 PRRSV_2b PF07069.11 KOO25107.1 - 0.062 13.8 0.2 0.094 13.2 0.2 1.3 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b COG5 PF10392.9 KOO25107.1 - 0.077 13.2 0.0 0.23 11.6 0.0 1.6 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DUF724 PF05266.14 KOO25107.1 - 0.09 12.6 0.6 0.1 12.4 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PheRS_DBD1 PF18552.1 KOO25107.1 - 0.14 11.9 0.9 1.4 8.8 0.1 2.5 1 1 2 3 3 3 0 PheRS DNA binding domain 1 SlyX PF04102.12 KOO25107.1 - 0.56 10.9 2.5 0.78 10.4 0.9 1.8 1 1 1 2 2 2 0 SlyX zf-CXXC PF02008.20 KOO25108.1 - 6.7e-11 42.0 18.0 1.1e-10 41.4 18.0 1.3 1 0 0 1 1 1 1 CXXC zinc finger domain Glyco_trans_1_3 PF13528.6 KOO25109.1 - 1.7e-10 40.7 0.0 3.7e-08 33.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.16 KOO25109.1 - 0.0021 18.0 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 KOO25109.1 - 0.024 13.5 0.0 0.039 12.8 0.0 1.2 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase CEP44 PF15007.6 KOO25110.1 - 9.6e-38 129.2 0.0 1.6e-37 128.5 0.0 1.3 1 0 0 1 1 1 1 Centrosomal spindle body, CEP44 IPK PF03770.16 KOO25111.1 - 0.036 13.9 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 Inositol polyphosphate kinase MatE PF01554.18 KOO25112.1 - 2.6e-17 62.9 36.0 7.7e-11 41.9 14.2 2.5 2 1 0 2 2 2 2 MatE Mur_ligase_M PF08245.12 KOO25113.1 - 3.9e-10 40.0 0.0 5.9e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Mur ligase middle domain Nucleotid_trans PF03407.16 KOO25114.1 - 0.00031 20.8 0.0 0.00036 20.6 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase PAN_1 PF00024.26 KOO25115.1 - 1e-14 54.2 15.3 0.00015 21.7 0.8 3.4 3 0 0 3 3 3 3 PAN domain PAN_4 PF14295.6 KOO25115.1 - 1.6e-09 37.5 26.5 2.7e-05 24.0 0.6 3.9 4 0 0 4 4 4 3 PAN domain MANEC PF07502.14 KOO25115.1 - 0.15 12.4 14.9 1.5 9.2 2.6 3.5 3 0 0 3 3 3 0 MANEC domain DUF4116 PF13475.6 KOO25116.1 - 1.6e-141 459.9 0.0 2.2e-15 56.1 0.0 9.2 4 2 8 12 12 12 12 Domain of unknown function (DUF4116) Rsbr_N PF08678.10 KOO25116.1 - 1.4e-08 34.8 0.0 7.9 6.6 0.0 7.3 2 2 9 11 11 11 2 Rsbr N terminal PRA-CH PF01502.18 KOO25116.1 - 0.00031 20.5 0.1 33 4.4 0.0 6.3 4 2 4 8 8 8 0 Phosphoribosyl-AMP cyclohydrolase TNT PF14021.6 KOO25116.1 - 0.0012 19.3 1.5 16 6.2 0.0 5.4 1 1 0 3 3 3 1 Tuberculosis necrotizing toxin gpW PF02831.15 KOO25116.1 - 0.028 14.3 0.1 14 5.6 0.0 4.0 3 0 0 3 3 3 0 gpW AdoMet_dc PF02675.15 KOO25116.1 - 0.034 14.4 1.0 8.1 6.8 0.0 4.0 2 2 1 4 4 4 0 S-adenosylmethionine decarboxylase DUF2150 PF09920.9 KOO25116.1 - 0.11 12.5 8.6 23 4.9 0.2 4.8 2 1 3 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2150) Fib_alpha PF08702.10 KOO25117.1 - 0.003 17.8 17.2 0.0089 16.2 5.4 2.6 2 0 0 2 2 2 2 Fibrinogen alpha/beta chain family DUF3584 PF12128.8 KOO25117.1 - 0.36 8.3 36.5 0.46 7.9 36.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ACR_tran PF00873.19 KOO25117.1 - 0.96 7.0 6.8 1.3 6.6 6.8 1.2 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family DUF1922 PF09082.10 KOO25117.1 - 4.3 7.7 7.0 8.3 6.8 0.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1922) Peptidase_C2 PF00648.21 KOO25118.1 - 3.1e-42 144.6 0.0 4.2e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KOO25118.1 - 3.5e-20 72.7 0.0 9.8e-09 35.6 0.0 3.7 3 1 0 3 3 3 3 Calpain large subunit, domain III DUF4399 PF14347.6 KOO25118.1 - 0.078 13.4 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4399) Polyketide_cyc PF03364.20 KOO25119.1 - 2.4e-12 47.2 0.0 2.8e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 KOO25119.1 - 9.1e-09 35.7 0.0 1.2e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport PHF5 PF03660.14 KOO25120.1 - 4.9e-51 171.3 13.9 5.4e-51 171.1 13.9 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 KOO25120.1 - 0.054 11.4 9.8 0.056 11.3 9.8 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 C1_2 PF03107.16 KOO25120.1 - 0.074 13.4 3.6 0.074 13.4 3.6 2.8 1 1 1 2 2 2 0 C1 domain DZR PF12773.7 KOO25120.1 - 4.8 7.3 20.2 0.43 10.7 3.2 2.9 1 1 1 2 2 2 0 Double zinc ribbon Glyco_hydro_6 PF01341.17 KOO25121.1 - 1.2e-63 215.7 0.0 1.2e-62 212.4 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 6 UPF0506 PF11703.8 KOO25121.1 - 0.16 12.4 2.7 0.51 10.8 0.4 2.4 2 0 0 2 2 2 0 UPF0506 Arm PF00514.23 KOO25122.1 - 1.5e-12 47.1 8.4 3.4e-05 23.7 0.1 5.2 4 1 1 5 5 5 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO25122.1 - 0.0033 17.9 12.6 0.04 14.4 4.3 2.9 3 0 0 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.6 KOO25122.1 - 0.041 14.3 10.1 3.2 8.2 0.1 3.5 3 1 1 4 4 4 0 HEAT repeats Exostosin PF03016.15 KOO25123.1 - 2.4e-19 69.7 1.1 6.9e-19 68.2 1.1 1.6 1 1 0 1 1 1 1 Exostosin family MoeA_N PF03453.17 KOO25125.1 - 2.6e-38 131.3 4.2 4.1e-38 130.6 4.2 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 KOO25125.1 - 7.8e-20 71.0 0.0 1.3e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_C PF03454.15 KOO25125.1 - 1.2e-14 54.2 0.1 3.1e-14 52.9 0.1 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Methyltransf_4 PF02390.17 KOO25126.1 - 1.5e-38 131.9 0.0 1.9e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.6 KOO25126.1 - 4.8e-06 26.4 0.3 8.7e-06 25.6 0.3 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO25126.1 - 9.3e-06 26.3 0.3 5e-05 23.9 0.3 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO25126.1 - 9.5e-05 22.3 0.0 0.0014 18.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO25126.1 - 0.00016 22.2 0.1 0.038 14.6 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO25126.1 - 0.015 16.0 0.1 0.26 12.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 KOO25126.1 - 0.027 14.0 0.3 0.18 11.3 0.3 1.9 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.7 KOO25126.1 - 0.058 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 KOO25126.1 - 0.062 13.3 0.0 0.084 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Orai-1 PF07856.12 KOO25127.1 - 7.4e-07 29.0 10.5 3.2e-06 26.9 10.5 1.9 1 1 0 1 1 1 1 Mediator of CRAC channel activity DUF1290 PF06947.12 KOO25127.1 - 0.5 10.5 3.4 1.1 9.3 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1290) ATG16 PF08614.11 KOO25128.1 - 0.00087 19.6 3.7 0.00087 19.6 3.7 6.0 4 2 2 6 6 6 1 Autophagy protein 16 (ATG16) CLAMP PF14769.6 KOO25129.1 - 1.3e-28 99.4 3.1 2e-28 98.8 3.1 1.3 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 adh_short PF00106.25 KOO25130.1 - 0.0029 17.1 2.9 0.024 14.1 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 KOO25130.1 - 0.0063 16.4 0.1 0.01 15.8 0.1 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 KOO25130.1 - 0.19 10.7 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Myb_DNA-binding PF00249.31 KOO25132.1 - 4.4e-23 81.2 0.5 1.9e-10 40.7 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO25132.1 - 1.5e-14 53.9 0.2 4.4e-06 26.8 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO25132.1 - 0.0021 17.9 0.0 0.33 10.9 0.0 2.2 2 0 0 2 2 2 2 Myb DNA-binding like Death PF00531.22 KOO25132.1 - 0.051 13.7 0.2 0.61 10.3 0.0 2.2 2 0 0 2 2 2 0 Death domain Peptidase_M16 PF00675.20 KOO25133.1 - 2.2e-21 76.4 0.1 6.3e-10 39.2 0.0 2.7 3 0 0 3 3 3 2 Insulinase (Peptidase family M16) DUF1583 PF07622.11 KOO25133.1 - 0.27 10.0 0.2 16 4.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1583) Colicin_Ia PF11504.8 KOO25133.1 - 0.76 9.9 3.4 46 4.2 0.1 3.5 1 1 2 3 3 3 0 Colicin Ia 2OG-FeII_Oxy PF03171.20 KOO25134.1 - 1.6e-15 57.4 0.0 2.7e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 KOO25134.1 - 1.6e-09 38.6 0.0 3e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Ras PF00071.22 KOO25135.1 - 3.9e-57 192.4 0.0 5.3e-57 191.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO25135.1 - 1.7e-20 73.4 0.0 2.4e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO25135.1 - 6.3e-10 38.8 0.0 7.2e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KOO25135.1 - 6e-05 23.0 0.1 0.26 11.2 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOO25135.1 - 6.6e-05 22.5 0.1 0.00024 20.7 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOO25135.1 - 0.00021 21.3 0.0 0.00033 20.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KOO25135.1 - 0.0018 17.8 0.0 0.003 17.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.18 KOO25135.1 - 0.0077 15.6 0.1 0.039 13.2 0.0 2.0 2 0 0 2 2 2 1 Septin ATP_bind_1 PF03029.17 KOO25135.1 - 0.0098 15.7 0.6 0.19 11.5 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 KOO25135.1 - 0.018 14.5 0.0 0.057 13.0 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B Rubredoxin PF00301.20 KOO25136.1 - 1.2e-10 41.2 5.3 1.7e-10 40.7 5.3 1.3 1 0 0 1 1 1 1 Rubredoxin HypA PF01155.19 KOO25136.1 - 0.00078 19.4 0.1 0.0013 18.8 0.1 1.4 1 1 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA eIF3g PF12353.8 KOO25136.1 - 0.084 13.3 0.2 0.14 12.5 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G TFIIS_C PF01096.18 KOO25136.1 - 0.29 11.0 4.0 4 7.4 0.2 2.4 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Elf1 PF05129.13 KOO25136.1 - 0.71 10.0 3.0 6.6 6.9 0.3 2.2 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 KOO25136.1 - 0.73 9.8 3.4 4.3 7.3 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 KOO25136.1 - 0.75 9.6 6.2 8 6.3 1.3 2.5 2 0 0 2 2 2 0 Rubredoxin metal binding domain adh_short_C2 PF13561.6 KOO25137.1 - 5.4e-55 186.5 0.1 7.4e-55 186.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO25137.1 - 3.8e-46 157.0 0.0 5.3e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOO25137.1 - 3.2e-07 30.4 0.3 4.9e-07 29.8 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOO25137.1 - 9.8e-05 21.9 0.4 0.00035 20.1 0.4 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KOO25137.1 - 0.0056 16.6 0.2 0.0086 16.0 0.2 1.4 1 1 0 1 1 1 1 NAD(P)H-binding DUF4226 PF10774.9 KOO25138.1 - 0.069 13.4 0.2 0.15 12.4 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4226) DnaJ PF00226.31 KOO25140.1 - 1.1e-14 54.2 0.2 2.4e-14 53.2 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain C2 PF00168.30 KOO25141.1 - 9.5e-17 61.2 0.0 1.8e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain Ion_trans PF00520.31 KOO25141.1 - 4.1e-15 55.7 6.3 5.7e-15 55.2 6.3 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 KOO25141.1 - 0.00021 21.3 0.0 0.00055 20.0 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Lig_chan PF00060.26 KOO25141.1 - 0.84 9.5 4.1 0.28 11.0 0.2 2.1 2 0 0 2 2 2 0 Ligand-gated ion channel Aldo_ket_red PF00248.21 KOO25142.1 - 2.3e-29 102.5 0.0 5.9e-20 71.6 0.1 2.8 1 1 1 2 2 2 2 Aldo/keto reductase family A_deaminase PF00962.22 KOO25143.1 - 6.7e-69 232.7 0.0 8.5e-69 232.4 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase AAA_6 PF12774.7 KOO25144.1 - 4.4e-151 502.4 0.0 6.5e-149 495.3 0.0 3.0 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO25144.1 - 2.2e-126 422.2 0.0 5.9e-126 420.8 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 KOO25144.1 - 5.3e-82 273.7 0.0 7.4e-80 266.7 0.0 3.3 3 0 0 3 3 2 1 P-loop containing dynein motor region AAA_8 PF12780.7 KOO25144.1 - 1.2e-49 168.9 0.0 3.6e-49 167.4 0.0 1.9 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_AAA_lid PF17852.1 KOO25144.1 - 8.3e-29 100.3 1.1 2.5e-28 98.7 0.1 2.5 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO25144.1 - 8.3e-18 64.7 0.0 3.3e-06 27.2 0.0 5.4 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 KOO25144.1 - 1e-16 61.0 0.6 3.9e-16 59.1 0.6 2.1 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 KOO25144.1 - 5.5e-07 30.1 0.0 0.052 14.0 0.0 4.2 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO25144.1 - 0.00022 21.6 0.0 0.57 10.5 0.0 3.7 3 0 0 3 3 3 1 AAA ATPase domain RNA_helicase PF00910.22 KOO25144.1 - 0.00076 19.8 0.1 2.5 8.5 0.0 3.6 3 0 0 3 3 2 1 RNA helicase AAA_22 PF13401.6 KOO25144.1 - 0.00088 19.6 0.1 0.61 10.4 0.0 3.8 4 0 0 4 4 4 1 AAA domain EF-hand_1 PF00036.32 KOO25144.1 - 0.0014 18.0 0.6 0.0062 16.0 0.6 2.2 1 0 0 1 1 1 1 EF hand AAA_30 PF13604.6 KOO25144.1 - 0.0037 17.0 0.2 4.3 7.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain EF-hand_6 PF13405.6 KOO25144.1 - 0.0085 15.9 0.7 0.042 13.8 0.7 2.3 1 0 0 1 1 1 1 EF-hand domain Sigma54_activat PF00158.26 KOO25144.1 - 0.0093 15.7 0.0 0.36 10.5 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain T2SSE PF00437.20 KOO25144.1 - 0.013 14.6 0.4 0.18 10.8 0.0 2.7 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_14 PF13173.6 KOO25144.1 - 0.046 13.7 0.0 1.8 8.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain EF-hand_7 PF13499.6 KOO25144.1 - 0.072 13.5 0.9 0.3 11.6 0.9 2.1 1 0 0 1 1 1 0 EF-hand domain pair ResIII PF04851.15 KOO25144.1 - 0.08 12.9 0.7 0.21 11.5 0.0 2.1 2 0 0 2 2 1 0 Type III restriction enzyme, res subunit NACHT PF05729.12 KOO25144.1 - 0.1 12.5 0.3 0.67 9.9 0.0 2.4 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 KOO25144.1 - 0.11 12.3 0.0 0.42 10.5 0.0 2.0 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 KOO25144.1 - 0.28 11.2 0.7 5.7 7.0 0.0 2.9 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 KOO25144.1 - 0.38 11.1 1.3 30 4.9 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_11 PF13086.6 KOO25144.1 - 0.51 10.1 2.0 32 4.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain EF-hand_1 PF00036.32 KOO25145.1 - 2.8e-24 82.8 4.8 7.2e-06 25.2 0.0 6.8 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO25145.1 - 1.9e-22 78.9 5.7 5.6e-05 22.9 0.0 5.9 5 1 1 6 6 6 5 EF-hand domain pair EF-hand_6 PF13405.6 KOO25145.1 - 2.6e-22 76.8 8.6 0.0038 17.0 0.0 7.4 8 0 0 8 8 8 5 EF-hand domain EF-hand_7 PF13499.6 KOO25145.1 - 2.4e-21 76.0 0.3 1.1e-08 35.3 0.0 4.3 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO25145.1 - 1.5e-16 59.1 2.5 2.5e-05 23.5 0.0 5.2 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 KOO25145.1 - 6.5e-05 23.2 0.7 1.8 8.9 0.1 3.5 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO25145.1 - 0.017 15.1 0.7 0.17 11.9 0.1 2.9 4 0 0 4 4 4 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO25145.1 - 0.068 13.5 0.6 9.7 6.6 0.1 3.8 3 1 0 3 3 3 0 EF-hand domain DUF3072 PF11272.8 KOO25145.1 - 0.12 12.3 0.1 0.28 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3072) Med3 PF11593.8 KOO25146.1 - 0.0046 16.2 1.1 0.0046 16.2 1.1 1.8 2 0 0 2 2 2 1 Mediator complex subunit 3 fungal MTP18 PF10558.9 KOO25147.1 - 2.5e-23 82.9 7.1 2.6e-16 60.1 0.2 2.9 1 1 2 3 3 3 2 Mitochondrial 18 KDa protein (MTP18) RE_HaeII PF09554.10 KOO25147.1 - 0.18 11.0 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 HaeII restriction endonuclease zf-PARP PF00645.18 KOO25149.1 - 3.4e-10 40.6 9.5 1.1e-08 35.8 1.4 2.4 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Adeno_52K PF03052.15 KOO25149.1 - 0.026 14.0 0.1 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 Adenoviral protein L1 52/55-kDa PIN_6 PF17146.4 KOO25151.1 - 4.5e-25 88.0 0.0 8.7e-25 87.0 0.0 1.5 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 KOO25151.1 - 1.3e-18 66.9 0.1 2.1e-18 66.2 0.1 1.3 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like DZR PF12773.7 KOO25151.1 - 0.025 14.6 0.1 0.043 13.8 0.1 1.3 1 0 0 1 1 1 0 Double zinc ribbon RNA_POL_M_15KD PF02150.16 KOO25151.1 - 0.094 12.6 1.9 0.14 12.1 0.3 2.0 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit zf-NADH-PPase PF09297.11 KOO25151.1 - 0.11 12.2 3.0 1.9 8.2 0.3 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain RecR PF02132.15 KOO25151.1 - 1.6 8.4 4.4 8.9 6.0 0.3 2.7 2 1 1 3 3 3 0 RecR protein Methyltransf_11 PF08241.12 KOO25154.1 - 6.9e-07 29.8 0.0 2e-06 28.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO25154.1 - 9e-06 26.3 0.0 2.1e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO25154.1 - 4.2e-05 23.4 0.0 7.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO25154.1 - 4.3e-05 22.9 0.0 8.6e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 KOO25154.1 - 0.00025 21.7 0.0 0.00047 20.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO25154.1 - 0.00053 19.8 0.0 0.00088 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 KOO25154.1 - 0.0012 18.5 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 KOO25154.1 - 0.0063 16.5 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO25154.1 - 0.013 15.3 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 KOO25154.1 - 0.21 11.7 0.0 0.63 10.1 0.0 1.6 1 1 1 2 2 2 0 FtsJ-like methyltransferase Methyltransf_11 PF08241.12 KOO25155.1 - 8.3e-09 36.0 0.0 1.7e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO25155.1 - 1.5e-05 25.6 0.0 5.2e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DSBA PF01323.20 KOO25155.1 - 0.00013 21.8 0.0 0.0003 20.6 0.0 1.5 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Ubie_methyltran PF01209.18 KOO25155.1 - 0.0016 17.8 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KOO25155.1 - 0.0028 17.5 0.0 0.0056 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO25155.1 - 0.0047 16.7 0.0 0.0078 16.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.18 KOO25155.1 - 0.0059 16.3 0.0 0.0092 15.7 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Methyltransf_12 PF08242.12 KOO25155.1 - 0.0077 17.0 0.0 0.019 15.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 KOO25155.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Sod_Ni PF09055.11 KOO25156.1 - 1.9e-27 96.4 2.6 5.8e-27 94.8 2.6 1.8 1 0 0 1 1 1 1 Nickel-containing superoxide dismutase WD40 PF00400.32 KOO25157.1 - 1.1e-46 155.8 18.7 1.7e-07 31.8 0.1 12.4 12 0 0 12 12 12 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO25157.1 - 1.7e-23 82.7 0.0 0.00013 22.2 0.0 8.8 5 2 3 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 KOO25157.1 - 5.7e-20 71.6 0.1 9.3e-20 70.9 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 KOO25157.1 - 1.7e-11 43.6 3.4 0.097 11.6 0.0 7.4 5 3 2 8 8 8 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO25157.1 - 5.7e-09 35.7 0.2 0.07 13.1 0.0 7.7 9 0 0 9 9 9 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 KOO25157.1 - 1.6e-05 24.4 0.5 0.74 9.1 0.0 4.7 4 1 1 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 KOO25157.1 - 0.0015 17.3 0.1 3.1 6.3 0.0 4.0 3 2 1 4 4 4 1 Nucleoporin Nup120/160 Hira PF07569.11 KOO25157.1 - 0.047 13.4 0.0 2.7 7.7 0.0 3.3 4 0 0 4 4 4 0 TUP1-like enhancer of split WD40_like PF17005.5 KOO25157.1 - 0.11 11.8 0.0 26 4.0 0.0 3.3 4 0 0 4 4 4 0 WD40-like domain TFIIIC_delta PF12657.7 KOO25157.1 - 0.23 11.4 0.4 6.1 6.7 0.0 3.0 3 0 0 3 3 3 0 Transcription factor IIIC subunit delta N-term PQQ_3 PF13570.6 KOO25157.1 - 9.4 6.9 11.3 34 5.1 0.0 5.5 7 0 0 7 7 6 0 PQQ-like domain EF-hand_1 PF00036.32 KOO25158.1 - 3.7e-15 54.2 0.1 3.7e-06 26.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO25158.1 - 9.4e-15 53.4 0.3 2.5e-06 26.7 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO25158.1 - 5.5e-14 52.4 0.0 1.1e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO25158.1 - 6.2e-14 50.7 0.1 1.5e-07 30.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO25158.1 - 1e-09 38.1 0.7 3.4e-05 23.6 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO25158.1 - 0.00015 22.0 0.0 0.00021 21.6 0.0 1.2 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO25158.1 - 0.003 17.5 0.3 0.31 11.0 0.1 2.2 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO25158.1 - 0.084 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain Caleosin PF05042.13 KOO25158.1 - 0.12 12.3 0.1 0.71 9.8 0.0 1.9 1 1 1 2 2 2 0 Caleosin related protein PspB PF06667.12 KOO25158.1 - 0.28 11.2 0.9 0.68 10.0 0.2 2.0 1 1 1 2 2 2 0 Phage shock protein B Ribosomal_L24e PF01246.20 KOO25159.1 - 7.3e-30 103.0 0.1 7.3e-30 103.0 0.1 2.3 3 0 0 3 3 3 1 Ribosomal protein L24e RR_TM4-6 PF06459.12 KOO25159.1 - 4.2 7.1 9.3 5 6.9 9.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 OTU PF02338.19 KOO25161.1 - 4e-08 33.8 0.0 1.2e-05 25.8 0.0 2.3 2 0 0 2 2 2 2 OTU-like cysteine protease Peptidase_C65 PF10275.9 KOO25161.1 - 4.6e-07 29.5 0.0 0.011 15.2 0.0 2.1 2 0 0 2 2 2 2 Peptidase C65 Otubain Sel1 PF08238.12 KOO25162.1 - 3.6e-71 234.0 67.2 1.5e-07 31.8 2.6 12.0 12 0 0 12 12 12 11 Sel1 repeat MOFRL PF05161.13 KOO25162.1 - 3.8e-05 23.8 25.9 0.02 15.1 0.7 6.5 1 1 5 7 7 7 5 MOFRL family Blt1_C PF17183.4 KOO25162.1 - 0.00052 19.6 2.0 5.8e+02 0.2 0.0 8.7 12 0 0 12 12 12 0 Get5 carboxyl domain ICAM_N PF03921.14 KOO25162.1 - 0.0036 17.0 0.0 87 2.9 0.0 5.3 8 0 0 8 8 8 0 Intercellular adhesion molecule (ICAM), N-terminal domain Fmp27_SW PF10305.9 KOO25162.1 - 0.036 14.8 3.5 79 4.0 0.0 5.3 6 0 0 6 6 6 0 RNA pol II promoter Fmp27 protein domain TPR_16 PF13432.6 KOO25164.1 - 3.1e-14 53.3 18.7 3.1e-06 27.7 0.1 4.9 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25164.1 - 2e-11 43.2 1.4 0.03 14.1 0.0 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25164.1 - 4.7e-09 35.8 0.9 0.15 12.3 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO25164.1 - 8.8e-09 35.5 19.7 1.3 10.0 0.1 6.9 3 3 3 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOO25164.1 - 2.4e-08 33.5 10.1 0.0087 15.7 0.7 5.0 3 1 2 5 5 5 3 TPR repeat TPR_19 PF14559.6 KOO25164.1 - 2.8e-08 34.2 14.1 0.0043 17.5 0.0 4.2 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO25164.1 - 4.5e-08 32.6 12.3 0.27 11.5 0.0 6.2 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25164.1 - 5.7e-08 32.9 9.4 0.11 12.8 3.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25164.1 - 1.9e-07 31.0 10.1 0.022 15.1 0.2 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO25164.1 - 7e-06 25.7 6.6 0.059 13.4 0.1 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO25164.1 - 6.2e-05 22.7 19.9 0.057 13.3 0.0 5.7 6 0 0 6 6 5 3 Tetratricopeptide repeat BTAD PF03704.17 KOO25164.1 - 0.0003 21.3 4.5 0.012 16.1 3.7 2.5 2 0 0 2 2 2 1 Bacterial transcriptional activator domain DUF4810 PF16068.5 KOO25164.1 - 0.00071 20.1 0.0 3.1 8.4 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4810) TPR_6 PF13174.6 KOO25164.1 - 0.0018 18.8 8.0 6.1 7.7 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 KOO25164.1 - 0.14 12.9 25.7 0.16 12.7 2.2 7.3 6 1 0 6 6 6 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 KOO25164.1 - 0.76 9.7 0.0 0.76 9.7 0.0 3.7 3 1 0 3 3 2 0 Virulence factor membrane-bound polymerase, C-terminal Agenet PF05641.12 KOO25166.1 - 5.8e-05 23.5 9.7 0.48 10.9 0.1 4.6 4 0 0 4 4 4 3 Agenet domain DnaJ PF00226.31 KOO25167.1 - 3.2e-06 27.2 0.1 7.2e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain Death PF00531.22 KOO25167.1 - 0.062 13.5 0.4 3.5 7.9 0.1 2.2 2 0 0 2 2 2 0 Death domain DUF3435 PF11917.8 KOO25167.1 - 1.4 7.8 5.9 1.8 7.4 5.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3435) MFS_1 PF07690.16 KOO25168.1 - 2.2e-17 63.0 28.8 6.2e-09 35.2 10.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO25168.1 - 7.1 5.4 14.2 2.4 6.9 4.7 2.1 2 0 0 2 2 2 0 Sugar (and other) transporter Spore_permease PF03845.13 KOO25170.1 - 0.00034 19.5 1.3 0.0007 18.5 1.3 1.5 1 0 0 1 1 1 1 Spore germination protein WD40 PF00400.32 KOO25172.1 - 1.1e-71 234.9 27.0 1.1e-09 38.7 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO25172.1 - 5.8e-21 74.8 8.7 0.017 14.1 0.0 7.0 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO25172.1 - 7.5e-20 71.0 5.1 0.069 13.5 0.0 7.0 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO25172.1 - 1.1e-15 57.1 1.6 0.23 11.4 0.0 7.0 7 0 0 7 7 7 5 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 KOO25172.1 - 2.8e-11 43.4 1.7 4.5 7.4 0.0 6.9 1 1 6 7 7 7 2 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 KOO25172.1 - 1.1e-10 40.4 0.0 0.067 11.5 0.0 4.7 1 1 4 5 5 5 4 WD repeat-containing and planar cell polarity effector protein Fritz DCX PF03607.17 KOO25172.1 - 1.1e-07 31.8 0.0 8.5 6.6 0.0 6.6 7 0 0 7 7 7 1 Doublecortin WD40_like PF17005.5 KOO25172.1 - 1.3e-05 24.7 0.7 6.8 5.9 0.0 5.1 2 2 1 5 5 5 2 WD40-like domain Plk4_PB1 PF18190.1 KOO25172.1 - 7.2e-05 22.9 0.3 32 4.7 0.0 5.7 1 1 6 7 7 7 0 Polo-like Kinase 4 Polo Box 1 WD40_3 PF15911.5 KOO25172.1 - 0.0022 17.9 1.7 1.5e+02 2.4 0.0 6.2 7 0 0 7 7 7 0 WD domain, G-beta repeat dsrm PF00035.26 KOO25172.1 - 0.0044 17.7 2.8 3.7 8.3 0.1 4.5 5 1 1 6 6 6 1 Double-stranded RNA binding motif rOmpB PF12334.8 KOO25172.1 - 0.031 13.8 9.9 10 5.5 0.1 5.8 1 1 3 6 6 6 0 Rickettsia outer membrane protein B HopJ PF08888.11 KOO25172.1 - 0.054 13.7 0.0 10 6.4 0.0 3.4 2 1 2 4 4 4 0 HopJ type III effector protein SpoU_methylase PF00588.19 KOO25173.1 - 6.7e-19 68.5 0.1 4e-18 66.0 0.0 2.0 2 0 0 2 2 2 1 SpoU rRNA Methylase family EF-hand_1 PF00036.32 KOO25174.1 - 8.4e-39 128.2 2.9 1.4e-07 30.5 0.3 8.3 8 0 0 8 8 8 6 EF hand EF-hand_6 PF13405.6 KOO25174.1 - 3.3e-36 120.1 8.5 3.3e-07 29.7 0.2 8.0 7 0 0 7 7 7 6 EF-hand domain Ank_4 PF13637.6 KOO25174.1 - 4e-35 119.7 1.9 5.9e-10 39.5 0.0 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) EF-hand_7 PF13499.6 KOO25174.1 - 9.3e-31 106.1 0.0 3.2e-07 30.7 0.1 5.4 5 0 0 5 5 5 4 EF-hand domain pair Ank_2 PF12796.7 KOO25174.1 - 1.6e-25 89.5 0.0 2.2e-13 50.6 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO25174.1 - 2.7e-22 78.1 3.9 0.00011 22.4 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat EF-hand_5 PF13202.6 KOO25174.1 - 3.6e-22 76.8 8.5 1.2e-06 27.7 0.4 7.3 7 0 0 7 7 7 4 EF hand Ank_3 PF13606.6 KOO25174.1 - 1.7e-19 67.8 2.0 0.001 19.3 0.0 5.8 6 0 0 6 6 5 3 Ankyrin repeat EF-hand_8 PF13833.6 KOO25174.1 - 3.2e-19 68.5 1.5 0.00049 19.9 0.0 6.2 5 2 1 6 6 6 5 EF-hand domain pair Ank_5 PF13857.6 KOO25174.1 - 2e-18 66.2 1.8 3.4e-06 27.2 0.0 4.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) EF-hand_9 PF14658.6 KOO25174.1 - 0.0014 18.9 0.1 12 6.3 0.0 4.3 4 0 0 4 4 4 1 EF-hand domain Dockerin_1 PF00404.18 KOO25174.1 - 0.011 16.0 1.5 10 6.4 0.5 3.7 2 1 2 4 4 4 0 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KOO25174.1 - 0.012 15.9 0.0 29 5.0 0.0 3.5 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO25174.1 - 0.02 14.8 0.0 21 5.0 0.0 3.7 3 1 1 4 4 4 0 Caleosin related protein PIG-L PF02585.17 KOO25174.1 - 0.079 13.6 0.3 21 5.8 0.0 3.1 1 1 1 2 2 2 0 GlcNAc-PI de-N-acetylase Ank_2 PF12796.7 KOO25175.1 - 3.8e-39 133.1 6.3 1.1e-13 51.6 0.1 5.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 KOO25175.1 - 2e-33 113.4 17.8 4.4e-05 23.7 0.0 9.4 9 0 0 9 9 9 7 Ankyrin repeat Ank_4 PF13637.6 KOO25175.1 - 3.1e-32 110.5 11.7 3.9e-08 33.7 0.2 7.8 4 3 4 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO25175.1 - 1.1e-29 102.1 18.1 1.4e-07 31.7 0.1 7.9 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO25175.1 - 4.6e-28 94.2 11.1 0.0038 17.6 0.0 9.4 9 0 0 9 9 9 8 Ankyrin repeat DUF4231 PF14015.6 KOO25176.1 - 8e-05 23.1 2.3 0.0047 17.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF4231) SLATT_1 PF18181.1 KOO25176.1 - 0.00071 19.5 8.1 0.00071 19.5 8.1 3.3 4 1 0 4 4 4 1 SMODS and SLOG-associating 2TM effector domain 1 DENN PF02141.21 KOO25177.1 - 2.1e-18 66.9 1.0 4e-18 66.0 1.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain GRAM PF02893.20 KOO25177.1 - 2.5e-09 37.0 0.0 3.7e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 GRAM domain DUF705 PF05152.12 KOO25177.1 - 0.0064 16.0 0.0 0.0093 15.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF705) COG6 PF06419.11 KOO25178.1 - 3.4e-43 147.8 0.2 4.2e-43 147.5 0.2 1.1 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Beach PF02138.18 KOO25180.1 - 2e-91 306.2 0.0 2.5e-91 305.9 0.0 1.1 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 KOO25180.1 - 1.4e-06 28.3 0.1 8.3e-06 25.8 0.0 2.3 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH Pkinase PF00069.25 KOO25182.1 - 2.4e-26 92.7 0.0 2.9e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25182.1 - 3.3e-12 46.2 0.0 7.4e-12 45.1 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO25182.1 - 1.9e-08 33.5 0.1 2.4e-08 33.2 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO25182.1 - 0.007 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KOO25182.1 - 0.047 12.7 0.6 0.075 12.0 0.6 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ank_2 PF12796.7 KOO25183.1 - 1.6e-41 140.7 19.9 1.3e-12 48.2 1.3 5.0 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO25183.1 - 8.8e-30 102.7 16.2 2.3e-09 37.6 0.4 6.4 4 2 2 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO25183.1 - 9.4e-29 99.1 31.3 4.8e-09 36.3 0.4 7.8 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 KOO25183.1 - 6.1e-27 92.9 40.5 0.0012 19.2 0.2 8.9 9 0 0 9 9 9 8 Ankyrin repeat Ank_3 PF13606.6 KOO25183.1 - 2.5e-17 61.2 25.6 0.016 15.7 0.2 9.2 9 0 0 9 9 9 5 Ankyrin repeat DUF4637 PF15470.6 KOO25183.1 - 0.02 14.7 0.8 0.047 13.4 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Mak_N_cap PF18085.1 KOO25183.1 - 2.3 9.3 5.6 18 6.4 0.2 4.3 1 1 3 4 4 4 0 Maltokinase N-terminal cap domain XRCC4 PF06632.12 KOO25183.1 - 8 5.2 7.5 11 4.8 7.5 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3623 PF12291.8 KOO25184.1 - 0.011 15.0 1.0 0.022 14.0 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3623) PGM_PMM_I PF02878.16 KOO25184.1 - 0.032 13.9 0.2 0.099 12.3 0.1 1.8 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Sulfotransfer_1 PF00685.27 KOO25185.1 - 1.1e-36 126.7 0.0 1.6e-36 126.2 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KOO25185.1 - 1.9e-10 41.5 0.0 4e-06 27.4 0.0 2.4 1 1 1 2 2 2 2 Sulfotransferase family Notch PF00066.17 KOO25186.1 - 0.014 15.8 7.8 0.035 14.6 7.8 1.6 1 0 0 1 1 1 0 LNR domain Galactosyl_T PF01762.21 KOO25188.1 - 7.2e-28 97.7 0.0 1e-27 97.2 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Ribosomal_60s PF00428.19 KOO25188.1 - 2.1 9.0 7.0 5.8 7.6 7.0 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein zf-RING_2 PF13639.6 KOO25189.1 - 1.4e-07 31.7 6.6 4.1e-07 30.2 6.6 1.8 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KOO25189.1 - 3.6e-06 27.2 5.5 6.2e-06 26.4 5.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain FANCL_C PF11793.8 KOO25189.1 - 6.8e-06 26.2 2.3 1.1e-05 25.5 2.3 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 KOO25189.1 - 0.002 18.2 1.7 0.0035 17.4 1.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 KOO25189.1 - 0.0063 16.5 1.3 0.043 13.8 0.6 2.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOO25189.1 - 0.014 15.3 6.8 0.03 14.3 6.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain RINGv PF12906.7 KOO25189.1 - 0.11 12.6 7.1 0.21 11.7 5.7 2.3 2 1 0 2 2 2 0 RING-variant domain zf-C3HC4_3 PF13920.6 KOO25189.1 - 0.13 12.1 8.0 0.47 10.3 8.0 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PHD_4 PF16866.5 KOO25189.1 - 0.4 10.8 4.0 0.79 9.9 4.0 1.5 1 0 0 1 1 1 0 PHD-finger zf-C3HC4 PF00097.25 KOO25189.1 - 0.42 10.5 6.2 2.7 8.0 6.2 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO25189.1 - 1.2 9.0 12.0 2.2e+02 1.8 12.0 3.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Glyco_transf_90 PF05686.12 KOO25190.1 - 3.2e-23 82.3 0.1 1.5e-22 80.1 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 90 ARL2_Bind_BART PF11527.8 KOO25191.1 - 0.026 14.6 0.0 0.055 13.6 0.0 1.5 1 1 1 2 2 2 0 The ARF-like 2 binding protein BART ShK PF01549.24 KOO25192.1 - 4.5e-46 155.1 82.4 1.4e-09 38.3 8.2 6.1 6 0 0 6 6 6 6 ShK domain-like zf-CCCH PF00642.24 KOO25192.1 - 8.3e-05 22.4 3.7 2.6 8.1 0.0 4.8 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Hist_deacetyl PF00850.19 KOO25193.1 - 6.5e-27 94.8 1.7 4e-25 88.9 1.7 2.0 1 1 0 1 1 1 1 Histone deacetylase domain Macoilin PF09726.9 KOO25195.1 - 0.0036 15.9 0.7 0.004 15.8 0.7 1.0 1 0 0 1 1 1 1 Macoilin family CREPT PF16566.5 KOO25195.1 - 0.014 15.5 0.2 0.018 15.2 0.2 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF296 PF03479.15 KOO25196.1 - 1.9e-27 95.7 0.9 2.3e-27 95.5 0.9 1.1 1 0 0 1 1 1 1 Plants and Prokaryotes Conserved (PCC) domain TMEM144 PF07857.12 KOO25197.1 - 4.9e-87 292.0 13.3 7.2e-80 268.5 9.7 2.2 2 0 0 2 2 2 2 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 KOO25197.1 - 3.5e-09 36.4 9.0 3.5e-09 36.4 9.0 2.9 3 1 0 3 3 3 2 Sugar transport protein Pescadillo_N PF06732.11 KOO25198.1 - 1.2e-105 353.0 0.1 1.6e-105 352.6 0.1 1.1 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT_2 PF16589.5 KOO25198.1 - 6.5e-07 29.7 0.0 1.2e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KOO25198.1 - 9.7e-05 22.7 0.0 0.00025 21.4 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 KOO25198.1 - 0.14 12.4 0.0 0.81 10.0 0.0 2.2 2 1 0 2 2 2 0 DNA ligase 3 BRCT domain Sugar_tr PF00083.24 KOO25201.1 - 9.6e-88 295.0 11.0 2.2e-87 293.8 11.0 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO25201.1 - 2.4e-19 69.5 32.2 1.6e-18 66.8 27.6 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KOO25201.1 - 0.061 11.6 0.1 0.1 10.9 0.1 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family EF-hand_7 PF13499.6 KOO25202.1 - 1.2e-07 32.0 0.3 3.1e-07 30.7 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO25202.1 - 7e-07 28.7 0.3 0.025 14.5 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO25202.1 - 3.4e-05 23.1 0.1 0.00082 18.7 0.2 2.5 2 0 0 2 2 2 1 EF hand EF-hand_10 PF14788.6 KOO25202.1 - 0.0036 17.1 0.1 0.0073 16.1 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO25202.1 - 0.0073 16.1 0.3 0.016 15.0 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO25202.1 - 0.062 12.8 0.3 0.13 11.8 0.3 1.5 1 0 0 1 1 1 0 EF hand WD40 PF00400.32 KOO25205.1 - 1.1e-64 212.8 19.6 9.4e-11 42.1 0.7 7.4 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO25205.1 - 1.2e-23 83.2 0.1 7.9e-06 26.1 0.0 6.3 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOO25205.1 - 1.7e-14 53.4 8.3 0.011 14.4 0.9 5.6 1 1 5 6 6 6 5 Nucleoporin Nup120/160 eIF2A PF08662.11 KOO25205.1 - 4.6e-09 36.4 0.0 0.00076 19.4 0.0 3.5 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOO25205.1 - 6.5e-08 31.9 6.7 0.28 10.1 0.1 5.1 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 KOO25205.1 - 2.6e-07 29.9 0.3 0.4 9.5 0.0 4.1 2 1 2 4 4 4 2 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 KOO25205.1 - 1.8e-05 24.2 0.0 0.011 15.1 0.0 3.1 2 1 2 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 KOO25205.1 - 0.00033 19.3 0.0 0.083 11.4 0.0 2.8 1 1 1 3 3 3 1 Cytochrome D1 heme domain VID27 PF08553.10 KOO25205.1 - 0.00048 19.3 0.0 0.88 8.6 0.0 3.9 1 1 4 5 5 5 1 VID27 C-terminal WD40-like domain Frtz PF11768.8 KOO25205.1 - 0.0043 15.4 0.0 0.22 9.8 0.0 2.1 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO25205.1 - 0.018 14.4 0.2 0.37 10.1 0.0 2.8 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 KOO25205.1 - 0.033 13.0 0.9 3 6.5 0.0 3.4 1 1 2 3 3 3 0 Nup133 N terminal like B12-binding PF02310.19 KOO25206.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 B12 binding domain RcpC PF16976.5 KOO25206.1 - 0.4 10.7 2.5 2.9 8.0 0.3 2.5 1 1 2 3 3 3 0 Flp pilus assembly protein RcpC/CpaB Shadoo PF14999.6 KOO25206.1 - 1.2 9.2 10.4 0.16 12.1 5.3 2.0 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Pkinase PF00069.25 KOO25207.1 - 1.8e-11 43.9 0.0 2.1e-11 43.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25207.1 - 9.3e-08 31.7 0.0 1.1e-07 31.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase SGTA_dimer PF16546.5 KOO25207.1 - 0.028 14.2 0.1 0.17 11.7 0.0 2.0 2 0 0 2 2 2 0 Homodimerisation domain of SGTA NAD_binding_8 PF13450.6 KOO25207.1 - 0.15 12.3 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain TAT_signal PF10518.9 KOO25208.1 - 0.022 14.6 5.2 0.046 13.6 5.2 1.6 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence PX PF00787.24 KOO25209.1 - 2.2e-11 43.7 0.0 3.4e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 PX domain VPS9 PF02204.18 KOO25209.1 - 2.5e-10 40.5 0.0 5.7e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain ART PF01129.18 KOO25210.1 - 0.00013 21.4 0.0 0.00028 20.3 0.0 1.5 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO25210.1 - 0.00029 20.2 0.0 0.4 10.0 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme zf-C2H2_6 PF13912.6 KOO25212.1 - 0.18 11.9 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger Ribosomal_S8e PF01201.22 KOO25213.1 - 2e-47 160.8 1.4 3.3e-47 160.1 1.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S8e RWD PF05773.22 KOO25214.1 - 7.3e-06 26.3 0.0 1.9e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 RWD domain DUF2288 PF10052.9 KOO25214.1 - 0.081 13.0 0.7 14 5.8 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2288) FH2 PF02181.23 KOO25214.1 - 0.087 11.9 0.1 0.13 11.4 0.1 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain Alpha_kinase PF02816.18 KOO25215.1 - 9.7e-14 51.9 0.0 1.5e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family Zn_Tnp_IS91 PF14319.6 KOO25216.1 - 0.0046 16.9 4.8 0.0046 16.9 4.8 2.6 3 1 1 4 4 4 1 Transposase zinc-binding domain PHD PF00628.29 KOO25216.1 - 0.0081 16.0 8.6 0.0081 16.0 8.6 2.2 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.6 KOO25216.1 - 0.015 15.0 3.1 0.04 13.6 3.1 1.7 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain zf-RING_6 PF14835.6 KOO25216.1 - 1.4 8.9 5.8 3.3 7.7 5.8 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein OB_NTP_bind PF07717.16 KOO25217.1 - 3.9e-18 65.6 0.0 6.2e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 KOO25217.1 - 9.6e-17 61.2 0.0 2.2e-16 60.1 0.0 1.7 1 1 0 1 1 1 1 Helicase associated domain (HA2) CaMKII_AD PF08332.10 KOO25218.1 - 4.8e-20 72.0 0.0 6.2e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain DUF4440 PF14534.6 KOO25218.1 - 5.3e-13 49.3 0.0 7.4e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 KOO25218.1 - 1.3e-07 31.9 0.1 1.8e-07 31.4 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_2 PF12680.7 KOO25218.1 - 6.9e-06 26.6 0.0 1e-05 26.1 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF3225 PF11533.8 KOO25218.1 - 0.082 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3225) Amino_oxidase PF01593.24 KOO25220.1 - 1.6e-23 83.8 0.5 9e-23 81.3 0.3 1.9 1 1 1 2 2 2 1 Flavin containing amine oxidoreductase Glyco_transf_9 PF01075.17 KOO25221.1 - 0.0025 17.2 0.1 56 2.9 0.0 4.1 4 0 0 4 4 4 4 Glycosyltransferase family 9 (heptosyltransferase) PH PF00169.29 KOO25222.1 - 0.00017 22.0 0.5 0.027 15.0 0.5 2.3 1 1 1 2 2 2 2 PH domain PH_8 PF15409.6 KOO25222.1 - 0.00027 21.2 0.4 0.00077 19.7 0.4 1.8 2 1 0 2 2 2 1 Pleckstrin homology domain COX6A PF02046.15 KOO25223.1 - 1.3e-06 28.8 0.0 2.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa MMgT PF10270.9 KOO25223.1 - 0.00054 20.3 0.0 0.0029 17.9 0.0 1.9 2 0 0 2 2 2 1 Membrane magnesium transporter DUF296 PF03479.15 KOO25223.1 - 0.037 14.4 0.0 0.061 13.7 0.0 1.2 1 0 0 1 1 1 0 Plants and Prokaryotes Conserved (PCC) domain MscS_porin PF12795.7 KOO25224.1 - 0.0026 17.4 4.2 0.0026 17.4 4.2 1.5 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain HR1 PF02185.16 KOO25224.1 - 0.017 15.2 0.9 6.6 6.9 1.1 2.5 2 1 0 2 2 2 0 Hr1 repeat Spc7 PF08317.11 KOO25224.1 - 0.091 11.6 0.6 0.092 11.6 0.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1547 PF07577.11 KOO25224.1 - 0.11 12.9 0.1 0.19 12.2 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1547) WXG100 PF06013.12 KOO25224.1 - 0.39 11.0 3.3 9.2 6.6 0.2 2.7 1 1 2 3 3 3 0 Proteins of 100 residues with WXG Macoilin PF09726.9 KOO25224.1 - 1 7.8 3.7 1.1 7.7 3.7 1.0 1 0 0 1 1 1 0 Macoilin family OB_NTP_bind PF07717.16 KOO25225.1 - 8e-18 64.6 0.0 1.7e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOO25225.1 - 2.9e-13 50.1 0.0 7.8e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 KOO25225.1 - 6e-13 49.0 0.0 1.9e-12 47.4 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 KOO25225.1 - 4.4e-11 42.9 0.2 7.4e-11 42.1 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOO25225.1 - 3.5e-06 27.4 0.1 1e-05 25.8 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO25225.1 - 0.00024 21.5 0.3 0.00062 20.1 0.2 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOO25225.1 - 0.0013 18.5 0.9 0.0013 18.5 0.9 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO25225.1 - 0.0038 17.6 2.3 0.0038 17.6 2.3 3.3 3 2 0 3 3 3 1 AAA ATPase domain ABC_tran PF00005.27 KOO25225.1 - 0.02 15.4 0.0 0.051 14.1 0.0 1.6 1 0 0 1 1 1 0 ABC transporter FtsK_SpoIIIE PF01580.18 KOO25225.1 - 0.11 11.8 0.0 0.32 10.3 0.0 1.8 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 KOO25225.1 - 0.16 11.7 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 KOO25225.1 - 0.18 11.8 0.0 0.6 10.1 0.0 1.9 2 0 0 2 2 2 0 Dynamin family ATPase PF06745.13 KOO25225.1 - 0.2 11.0 0.0 0.41 10.0 0.0 1.4 1 0 0 1 1 1 0 KaiC SICA_C PF12879.7 KOO25226.1 - 0.0087 16.1 1.0 0.011 15.8 1.0 1.2 1 0 0 1 1 1 1 SICA C-terminal inner membrane domain Myosin_head PF00063.21 KOO25227.1 - 9.8e-179 595.8 0.0 5.4e-79 266.2 0.0 3.0 3 0 0 3 3 3 3 Myosin head (motor domain) BTB_2 PF02214.22 KOO25227.1 - 4e-06 27.1 0.0 5e-05 23.6 0.0 2.4 1 1 0 1 1 1 1 BTB/POZ domain Myosin_N PF02736.19 KOO25227.1 - 2.8e-05 23.9 3.2 5.6e-05 22.9 3.2 1.5 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 KOO25227.1 - 0.077 13.3 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO25227.1 - 0.2 12.0 0.1 0.2 12.0 0.1 2.9 3 0 0 3 3 3 0 AAA ATPase domain Rad9 PF04139.13 KOO25228.1 - 4.9e-49 167.0 0.0 5.8e-49 166.8 0.0 1.0 1 0 0 1 1 1 1 Rad9 PCNA_N PF00705.18 KOO25228.1 - 0.043 13.5 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, N-terminal domain C4 PF01413.19 KOO25228.1 - 0.24 11.8 0.0 0.24 11.8 0.0 1.9 2 0 0 2 2 2 0 C-terminal tandem repeated domain in type 4 procollagen DXP_reductoisom PF02670.16 KOO25229.1 - 3.4e-42 144.2 0.3 5.9e-42 143.4 0.3 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DXPR_C PF13288.6 KOO25229.1 - 1.5e-35 121.9 0.0 3.2e-35 120.9 0.0 1.6 1 0 0 1 1 1 1 DXP reductoisomerase C-terminal domain DXP_redisom_C PF08436.12 KOO25229.1 - 8.8e-35 118.7 0.0 1.6e-34 117.9 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain Toprim_C_rpt PF13368.6 KOO25231.1 - 4.6e-15 55.3 0.0 3.7e-07 30.0 0.0 4.5 3 2 0 3 3 3 2 Topoisomerase C-terminal repeat HMG_box PF00505.19 KOO25231.1 - 6.9e-11 42.4 0.0 1.4e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box SAP PF02037.27 KOO25231.1 - 5.2e-08 32.5 0.7 9.5e-08 31.6 0.7 1.4 1 0 0 1 1 1 1 SAP domain zf-C4_Topoisom PF01396.19 KOO25231.1 - 1.7e-06 27.7 0.3 2.9e-06 27.0 0.3 1.4 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger HMG_box_2 PF09011.10 KOO25231.1 - 1.3e-05 25.7 0.0 3e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 HMG-box domain EF-hand_1 PF00036.32 KOO25233.1 - 2.2e-24 83.1 5.6 4.4e-05 22.7 0.0 4.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO25233.1 - 1.1e-22 80.2 1.1 4.5e-10 39.8 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO25233.1 - 1.9e-21 74.1 7.1 0.00021 21.0 0.0 4.7 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 KOO25233.1 - 4.5e-20 70.2 7.4 0.00027 20.3 0.2 5.3 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO25233.1 - 5.2e-17 61.4 1.7 0.00029 20.6 0.0 4.8 4 1 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO25233.1 - 2.4e-06 27.8 0.7 0.0089 16.3 0.2 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO25233.1 - 0.012 15.6 0.8 15 5.6 0.0 3.3 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand Peptidase_C48 PF02902.19 KOO25234.1 - 2.5e-29 102.7 0.0 5.5e-29 101.6 0.0 1.6 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain SAM_1 PF00536.30 KOO25234.1 - 3.3e-13 49.9 0.1 7.8e-13 48.7 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO25234.1 - 5.1e-13 48.9 0.1 9.2e-13 48.1 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) THRAP3_BCLAF1 PF15440.6 KOO25234.1 - 0.29 10.1 1.9 0.4 9.6 1.9 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family Sel1 PF08238.12 KOO25235.1 - 6.8e-16 58.4 34.6 8.6e-07 29.4 0.1 7.9 9 0 0 9 9 9 4 Sel1 repeat Glutaredoxin PF00462.24 KOO25235.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin LSM PF01423.22 KOO25236.1 - 1.7e-14 53.3 0.3 2.2e-14 52.9 0.3 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOO25236.1 - 0.00039 20.5 0.0 0.00053 20.1 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF2642 PF10842.8 KOO25236.1 - 0.12 12.3 0.1 0.26 11.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2642) Exostosin PF03016.15 KOO25237.1 - 6e-13 48.7 0.0 2.2e-12 46.8 0.0 1.8 2 0 0 2 2 2 1 Exostosin family Galactosyl_T PF01762.21 KOO25237.1 - 2.6e-10 40.4 0.0 5.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Galactosyltransferase SHIPPO-rpt PF07004.12 KOO25238.1 - 0.032 15.1 4.7 0.032 15.1 4.7 3.2 3 1 0 3 3 3 0 Sperm-tail PG-rich repeat Phytochelatin PF05023.14 KOO25239.1 - 2.8e-30 105.1 0.0 4.6e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Phytochelatin synthase PseudoU_synth_2 PF00849.22 KOO25239.1 - 0.0034 17.5 0.0 0.0049 17.0 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Peptidase_C39_2 PF13529.6 KOO25239.1 - 0.0086 16.6 0.1 0.18 12.4 0.0 2.2 2 0 0 2 2 2 1 Peptidase_C39 like family CmcI PF04989.12 KOO25240.1 - 8.4e-32 110.5 0.0 9.4e-30 103.8 0.0 2.7 1 1 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_24 PF13578.6 KOO25240.1 - 0.00045 21.2 0.0 0.00084 20.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain 6PF2K PF01591.18 KOO25241.1 - 2.7e-55 187.1 0.0 4e-55 186.5 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOO25241.1 - 1.1e-13 51.3 0.0 5.8e-11 42.4 0.0 2.9 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) PDZ PF00595.24 KOO25241.1 - 0.0029 17.9 0.0 0.0058 16.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain AAA_33 PF13671.6 KOO25241.1 - 0.0056 16.9 0.2 0.021 15.0 0.2 2.1 1 1 0 1 1 1 1 AAA domain PDZ_6 PF17820.1 KOO25241.1 - 0.0064 16.3 0.0 0.014 15.2 0.0 1.7 1 0 0 1 1 1 1 PDZ domain cobW PF02492.19 KOO25242.1 - 3e-50 170.3 0.5 4.2e-50 169.8 0.5 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KOO25242.1 - 1.9e-17 63.0 0.1 9.9e-17 60.7 0.1 2.3 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 KOO25242.1 - 0.0012 18.8 0.0 0.34 10.8 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MeaB PF03308.16 KOO25242.1 - 0.028 13.4 0.2 1.2 8.1 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 KOO25242.1 - 0.029 14.6 0.0 0.071 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KOO25242.1 - 0.037 13.9 0.0 0.067 13.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 KOO25242.1 - 0.045 13.8 0.1 0.09 12.8 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SpecificRecomb PF10136.9 KOO25242.1 - 0.053 11.8 0.0 0.076 11.3 0.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase AAA_16 PF13191.6 KOO25242.1 - 0.06 13.7 0.0 0.16 12.3 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain MobB PF03205.14 KOO25242.1 - 0.097 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Pkinase_Tyr PF07714.17 KOO25243.1 - 1.7e-49 168.5 0.0 2.1e-49 168.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO25243.1 - 1.7e-43 148.9 0.0 2.3e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PX PF00787.24 KOO25243.1 - 2e-05 24.5 0.0 3.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 PX domain APH PF01636.23 KOO25243.1 - 0.33 10.8 5.9 0.38 10.6 0.0 3.2 3 1 1 4 4 4 0 Phosphotransferase enzyme family RdRP PF05183.12 KOO25244.1 - 3.1e-65 221.0 0.0 4.4e-65 220.4 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase EF-hand_7 PF13499.6 KOO25245.1 - 2.9e-23 82.1 2.7 6.8e-08 32.9 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO25245.1 - 2.1e-18 64.6 1.1 0.00042 20.0 0.0 6.2 6 0 0 6 6 6 3 EF-hand domain EF-hand_1 PF00036.32 KOO25245.1 - 7.6e-18 62.7 5.8 0.00023 20.5 0.0 6.0 6 0 0 6 6 6 4 EF hand Ank_2 PF12796.7 KOO25245.1 - 4.4e-17 62.4 0.2 7e-10 39.4 0.0 2.7 2 1 1 3 3 2 2 Ankyrin repeats (3 copies) EF-hand_5 PF13202.6 KOO25245.1 - 3.9e-12 45.1 3.6 0.032 13.7 0.0 5.6 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 KOO25245.1 - 2.7e-11 43.1 3.8 0.015 15.1 0.0 5.7 4 2 2 6 6 6 2 EF-hand domain pair Ank_4 PF13637.6 KOO25245.1 - 1.8e-08 34.8 0.3 1.2e-06 28.9 0.2 3.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) SPARC_Ca_bdg PF10591.9 KOO25245.1 - 3.5e-07 30.5 0.4 1.2 9.5 0.0 4.1 3 0 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Ank_3 PF13606.6 KOO25245.1 - 4.8e-07 29.6 0.3 0.086 13.4 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KOO25245.1 - 8.3e-06 26.0 0.2 0.087 13.2 0.0 3.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_9 PF14658.6 KOO25245.1 - 0.0035 17.7 0.1 20 5.6 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain Ank PF00023.30 KOO25245.1 - 0.0049 17.3 0.1 2.4 8.7 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat EF-hand_10 PF14788.6 KOO25245.1 - 0.01 15.7 3.5 7.1 6.6 0.0 4.6 5 0 0 5 5 5 0 EF hand DUF2368 PF10166.9 KOO25245.1 - 4.8 6.8 10.9 4 7.1 0.5 3.4 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2368) ORC2 PF04084.14 KOO25246.1 - 2.2e-32 112.3 0.0 2.8e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Cortex-I_coil PF09304.10 KOO25247.1 - 0.014 15.6 0.8 0.014 15.6 0.8 1.8 2 0 0 2 2 2 0 Cortexillin I, coiled coil DUF3450 PF11932.8 KOO25247.1 - 0.022 14.1 2.4 0.044 13.1 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4349 PF14257.6 KOO25247.1 - 0.028 13.9 0.5 0.06 12.8 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Cob_adeno_trans PF01923.18 KOO25247.1 - 0.069 13.3 0.7 0.51 10.5 0.1 2.2 2 0 0 2 2 2 0 Cobalamin adenosyltransferase Sre PF03125.18 KOO25247.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor DUF3461 PF11944.8 KOO25247.1 - 0.13 12.4 0.2 0.22 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) DUF1664 PF07889.12 KOO25247.1 - 0.17 12.0 0.4 0.29 11.2 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) MIP-T3_C PF17749.1 KOO25247.1 - 0.75 9.8 5.4 2.5 8.0 3.5 1.9 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region DnaB_bind PF10410.9 KOO25247.1 - 2 8.7 5.7 2.1 8.6 0.3 3.2 3 0 0 3 3 3 0 DnaB-helicase binding domain of primase Utp11 PF03998.13 KOO25248.1 - 7.1e-62 209.5 10.5 8.2e-62 209.3 10.5 1.0 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 KOO25248.1 - 0.0075 15.6 0.8 0.013 14.8 0.2 1.6 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain family 5 DHBP_synthase PF00926.19 KOO25248.1 - 0.052 13.1 0.0 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 3,4-dihydroxy-2-butanone 4-phosphate synthase DUF4810 PF16068.5 KOO25248.1 - 0.18 12.4 3.5 1 10.0 0.0 3.2 3 2 0 3 3 3 0 Domain of unknown function (DUF4810) Apc13p PF05839.11 KOO25249.1 - 0.0018 18.4 3.7 0.032 14.4 3.7 2.0 1 1 0 1 1 1 1 Apc13p protein DUF4193 PF13834.6 KOO25249.1 - 0.063 13.8 0.0 0.074 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4193) HSP70 PF00012.20 KOO25250.1 - 5.6e-101 338.6 0.2 7.6e-101 338.1 0.2 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOO25250.1 - 4.5e-13 48.7 5.5 1.2e-08 34.2 0.7 3.0 3 0 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.6 KOO25250.1 - 8.8e-09 35.7 0.3 0.0014 19.0 0.0 3.3 3 0 0 3 3 3 2 Cell division protein FtsA DDR PF08841.10 KOO25250.1 - 0.047 12.7 4.1 0.15 11.0 4.1 1.9 1 1 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain TPP_enzyme_N PF02776.18 KOO25250.1 - 0.052 13.2 3.2 0.062 12.9 1.2 2.0 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain StbA PF06406.11 KOO25250.1 - 0.17 11.1 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 StbA protein Aminotran_3 PF00202.21 KOO25251.1 - 2.6e-65 220.7 0.0 3.6e-65 220.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DUF228 PF02989.14 KOO25251.1 - 0.03 14.1 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Lyme disease proteins of unknown function Amino_oxidase PF01593.24 KOO25253.1 - 9.7e-52 176.8 0.0 1.2e-51 176.5 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO25253.1 - 4.3e-12 46.1 0.1 1e-11 44.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO25253.1 - 1.4e-05 24.8 0.0 3.9e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 KOO25253.1 - 0.00012 21.6 0.0 0.00017 21.1 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOO25253.1 - 0.00065 18.9 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 KOO25253.1 - 0.0017 17.7 0.3 0.0024 17.2 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 KOO25253.1 - 0.0042 16.4 0.2 0.0073 15.6 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 KOO25253.1 - 0.021 14.4 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 KOO25253.1 - 0.027 13.8 0.6 0.044 13.1 0.6 1.2 1 0 0 1 1 1 0 ThiF family GIDA PF01134.22 KOO25253.1 - 0.027 13.6 0.0 0.036 13.1 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 KOO25253.1 - 0.03 14.9 0.1 0.063 13.9 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KOO25253.1 - 0.078 12.0 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 KOO25253.1 - 0.12 11.6 0.2 0.22 10.7 0.2 1.3 1 0 0 1 1 1 0 Thi4 family DUF1736 PF08409.11 KOO25254.1 - 0.0025 17.8 0.7 0.012 15.6 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1736) DnaJ PF00226.31 KOO25254.1 - 0.0027 17.8 0.0 0.0051 16.9 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain LRR_6 PF13516.6 KOO25255.1 - 1.9e-17 61.8 33.8 0.02 14.9 0.1 12.0 12 0 0 12 12 12 6 Leucine Rich repeat LRR_4 PF12799.7 KOO25255.1 - 4.1e-08 33.4 23.0 0.9 10.1 0.0 8.8 6 2 1 8 8 8 4 Leucine Rich repeats (2 copies) IQ PF00612.27 KOO25255.1 - 6.1e-07 28.7 36.9 0.11 12.4 0.9 6.0 5 0 0 5 5 5 5 IQ calmodulin-binding motif NACHT PF05729.12 KOO25255.1 - 0.001 19.0 0.0 0.0041 17.1 0.0 2.1 1 1 0 1 1 1 1 NACHT domain LRR_1 PF00560.33 KOO25255.1 - 0.012 16.0 10.4 64 4.7 0.0 8.6 10 1 0 10 10 10 0 Leucine Rich Repeat AAA_22 PF13401.6 KOO25255.1 - 0.012 15.8 0.1 0.14 12.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain LRR_8 PF13855.6 KOO25255.1 - 0.034 13.9 27.0 0.26 11.1 0.9 8.3 6 2 3 9 9 9 0 Leucine rich repeat AAA_18 PF13238.6 KOO25255.1 - 0.036 14.6 0.0 0.18 12.4 0.0 2.2 1 0 0 1 1 1 0 AAA domain Glyco_transf_90 PF05686.12 KOO25256.1 - 1.2e-38 133.1 0.0 1.3e-36 126.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 KOO25256.1 - 0.0049 17.2 0.0 0.0091 16.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 P_C10 PF14974.6 KOO25257.1 - 0.0012 18.9 0.0 0.0024 17.9 0.0 1.6 1 0 0 1 1 1 1 Protein C10 VWA_CoxE PF05762.14 KOO25257.1 - 0.017 14.5 0.1 0.017 14.5 0.1 1.8 3 0 0 3 3 3 0 VWA domain containing CoxE-like protein WW PF00397.26 KOO25258.1 - 9e-09 35.3 4.1 1.9e-08 34.2 4.1 1.6 1 0 0 1 1 1 1 WW domain TIR_2 PF13676.6 KOO25258.1 - 3.9e-07 30.7 0.0 1.4e-06 28.9 0.0 2.0 1 0 0 1 1 1 1 TIR domain Ribosomal_L13e PF01294.18 KOO25258.1 - 2.4e-05 24.3 24.2 5.2 6.9 0.1 10.4 1 1 5 11 11 11 3 Ribosomal protein L13e MerR_1 PF13411.6 KOO25258.1 - 0.0002 21.4 0.0 22 5.3 0.0 7.5 9 2 2 12 12 12 1 MerR HTH family regulatory protein RPAP1_C PF08620.10 KOO25258.1 - 0.0082 16.2 2.7 21 5.3 0.0 6.0 5 2 0 5 5 5 1 RPAP1-like, C-terminal SinI PF08671.10 KOO25258.1 - 0.53 10.1 11.3 40 4.1 0.0 8.6 7 1 1 8 8 8 0 Anti-repressor SinI DUF2774 PF11242.8 KOO25258.1 - 2.4 8.4 4.1 90 3.4 0.0 4.3 5 0 0 5 5 5 0 Protein of unknown function (DUF2774) MOSC_N PF03476.16 KOO25258.1 - 8.4 6.3 10.7 25 4.8 0.6 5.2 2 1 3 5 5 5 0 MOSC N-terminal beta barrel domain Tom37 PF10568.9 KOO25259.1 - 2e-23 83.1 0.0 5.1e-23 81.7 0.0 1.7 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 KOO25259.1 - 8.8e-20 70.3 0.0 1.9e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KOO25259.1 - 1.7e-14 54.4 0.0 5.5e-14 52.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 KOO25259.1 - 0.00012 22.0 0.1 0.00027 20.9 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Spt5-NGN PF03439.13 KOO25260.1 - 1.9e-18 66.1 0.1 3.7e-18 65.2 0.1 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section DUF1287 PF06940.11 KOO25260.1 - 0.025 14.3 0.0 0.084 12.5 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) KOW PF00467.29 KOO25260.1 - 0.069 13.1 22.4 0.26 11.3 0.3 5.1 6 0 0 6 6 6 0 KOW motif Myb_CC_LHEQLE PF14379.6 KOO25260.1 - 0.14 11.8 5.8 0.2 11.4 3.6 2.3 2 0 0 2 2 2 0 MYB-CC type transfactor, LHEQLE motif tRNA_bind_2 PF13725.6 KOO25261.1 - 4.2e-58 196.8 0.0 5.9e-58 196.3 0.0 1.2 1 0 0 1 1 1 1 Possible tRNA binding domain DUF1726 PF08351.11 KOO25261.1 - 1.7e-33 114.4 0.0 4e-33 113.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) Helicase_RecD PF05127.14 KOO25261.1 - 3.7e-32 111.6 0.0 1.4e-31 109.7 0.0 1.9 2 0 0 2 2 2 1 Helicase GNAT_acetyltr_2 PF13718.6 KOO25261.1 - 2e-21 76.5 2.1 3.5e-19 69.1 0.5 2.4 1 1 1 2 2 2 2 GNAT acetyltransferase 2 NUC173 PF08161.12 KOO25261.1 - 0.089 12.4 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 NUC173 domain DEAD PF00270.29 KOO25261.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase DUF1572 PF07609.11 KOO25262.1 - 0.13 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1572) UPF0220 PF05255.11 KOO25263.1 - 2e-20 73.0 3.5 5.5e-20 71.6 3.5 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0220) TssN PF17555.2 KOO25263.1 - 0.11 11.8 0.8 0.17 11.2 0.8 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN PDZ_6 PF17820.1 KOO25266.1 - 0.00018 21.2 0.1 0.00032 20.5 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO25266.1 - 0.0002 21.7 0.0 0.00034 20.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO25266.1 - 0.009 16.3 0.0 0.023 15.0 0.0 1.6 1 1 1 2 2 2 1 PDZ domain polyprenyl_synt PF00348.17 KOO25267.1 - 2.8e-85 285.5 0.2 3.5e-85 285.1 0.2 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Cellulase PF00150.18 KOO25268.1 - 5.1e-32 111.4 0.0 1e-31 110.4 0.0 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Pro_isomerase PF00160.21 KOO25269.1 - 9.5e-29 100.7 0.0 1.5e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ZZ PF00569.17 KOO25270.1 - 0.00014 21.6 0.0 0.00022 21.0 0.0 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF4407 PF14362.6 KOO25270.1 - 8.3 5.7 19.1 12 5.1 19.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 KOO25270.1 - 8.8 6.1 14.7 10 5.8 14.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SpoU_methylase PF00588.19 KOO25271.1 - 4.5e-30 104.7 0.0 6.6e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family EGF_2 PF07974.13 KOO25271.1 - 0.00011 22.5 7.7 0.00042 20.6 7.7 2.1 1 0 0 1 1 1 1 EGF-like domain Na_H_Exchanger PF00999.21 KOO25274.1 - 3.2e-46 157.8 43.2 4e-46 157.5 43.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family EF-hand_1 PF00036.32 KOO25274.1 - 0.00078 18.8 0.0 0.18 11.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO25274.1 - 0.0011 18.4 0.0 0.6 9.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO25274.1 - 0.0029 18.0 0.0 0.062 13.8 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO25274.1 - 0.098 12.5 0.0 5.3 7.0 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair tRNA_m1G_MT PF01746.21 KOO25275.1 - 2.6e-25 89.3 0.1 5.4e-25 88.2 0.0 1.5 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase DUF5037 PF16440.5 KOO25275.1 - 0.055 13.0 0.3 0.091 12.3 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5037) DUF2828 PF11443.8 KOO25275.1 - 1.9 6.5 9.8 2.8 5.9 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) C2 PF00168.30 KOO25276.1 - 2.6e-22 79.1 0.0 2.7e-15 56.5 0.0 3.6 3 0 0 3 3 3 2 C2 domain PTEN_C2 PF10409.9 KOO25276.1 - 0.0034 17.1 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Transglut_core PF01841.19 KOO25276.1 - 0.14 12.6 0.0 0.46 10.9 0.0 1.9 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF3450 PF11932.8 KOO25277.1 - 0.1 11.9 13.7 0.25 10.6 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) KASH_CCD PF14662.6 KOO25277.1 - 0.18 11.6 4.4 0.83 9.5 0.2 2.3 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Fib_alpha PF08702.10 KOO25277.1 - 0.2 11.8 1.4 19 5.5 0.3 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family YabA PF06156.13 KOO25277.1 - 0.27 11.9 1.8 1.3 9.7 0.1 2.7 3 0 0 3 3 3 0 Initiation control protein YabA TSC22 PF01166.18 KOO25277.1 - 0.29 11.5 1.4 0.54 10.6 0.1 2.0 2 0 0 2 2 2 0 TSC-22/dip/bun family Filament PF00038.21 KOO25277.1 - 0.48 9.9 12.2 1.5 8.3 3.3 2.3 1 1 1 2 2 2 0 Intermediate filament protein ADIP PF11559.8 KOO25277.1 - 0.75 9.9 11.7 0.29 11.2 1.6 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding TPT PF03151.16 KOO25278.1 - 1.7e-18 67.0 9.0 2e-18 66.8 9.0 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family PPR_2 PF13041.6 KOO25279.1 - 2.1e-16 59.8 0.0 4.9e-05 23.4 0.0 5.3 3 1 2 5 5 5 4 PPR repeat family DnaJ PF00226.31 KOO25279.1 - 4.7e-13 49.1 0.1 1.1e-12 47.9 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain PPR_3 PF13812.6 KOO25279.1 - 1.9e-11 43.8 0.0 0.0011 19.0 0.0 4.1 3 1 1 4 4 4 3 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO25279.1 - 1.1e-05 24.9 0.0 0.002 17.5 0.0 2.2 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 KOO25279.1 - 5.1e-05 23.2 10.0 0.66 10.3 0.0 5.3 6 0 0 6 6 6 2 PPR repeat PPR_1 PF12854.7 KOO25279.1 - 5.8e-05 22.7 0.5 0.21 11.3 0.0 3.8 4 0 0 4 4 4 2 PPR repeat PALP PF00291.25 KOO25279.1 - 0.0049 16.3 0.1 0.016 14.6 0.1 1.8 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Sensor_TM1 PF13755.6 KOO25280.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Sensor N-terminal transmembrane domain Methyltr_RsmB-F PF01189.17 KOO25281.1 - 7.4e-26 91.0 0.0 1.1e-25 90.5 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KOO25281.1 - 3.3e-05 24.1 0.0 5.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ribosomal_L4 PF00573.22 KOO25282.1 - 2.1e-37 128.7 0.1 3.4e-37 128.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 KOO25282.1 - 4e-20 71.6 5.2 1.2e-19 70.2 4.0 2.1 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain PolyA_pol PF01743.20 KOO25283.1 - 4.4e-06 27.2 0.3 2.5e-05 24.7 0.3 1.9 1 1 0 1 1 1 1 Poly A polymerase head domain 2OG-FeII_Oxy_3 PF13640.6 KOO25285.1 - 3.9e-12 46.9 0.1 6.3e-12 46.2 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO25285.1 - 6e-06 26.7 0.0 8.6e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO25285.1 - 0.0018 18.9 0.0 0.0029 18.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 KOO25285.1 - 0.0069 15.9 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 Oxygenase, catalysing oxidative methylation of damaged DNA SET PF00856.28 KOO25287.1 - 1.8e-08 34.9 5.1 1.6e-06 28.7 0.0 3.7 2 2 0 2 2 2 1 SET domain BT1 PF03092.16 KOO25287.1 - 0.076 11.2 0.8 0.1 10.8 0.8 1.1 1 0 0 1 1 1 0 BT1 family Phage_min_cap2 PF06152.11 KOO25287.1 - 0.3 9.9 5.6 0.44 9.4 5.6 1.1 1 0 0 1 1 1 0 Phage minor capsid protein 2 Rieske PF00355.26 KOO25288.1 - 4.9e-21 74.5 0.0 9.1e-21 73.6 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 KOO25288.1 - 0.012 15.5 0.0 0.071 13.1 0.0 2.3 2 1 0 2 2 2 0 Rieske-like [2Fe-2S] domain GMC_oxred_N PF00732.19 KOO25289.1 - 1.2e-71 241.6 0.1 1.8e-71 241.0 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOO25289.1 - 2.4e-32 112.4 0.3 4.5e-32 111.6 0.3 1.5 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 KOO25289.1 - 4.9e-06 26.7 0.6 1.6e-05 25.1 0.6 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KOO25289.1 - 8.8e-05 21.4 0.1 0.00013 20.8 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 KOO25289.1 - 9.7e-05 21.6 0.3 0.00014 21.0 0.3 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 KOO25289.1 - 0.00066 19.0 0.1 0.0013 18.0 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO25289.1 - 0.0017 17.5 0.5 0.0036 16.4 0.5 1.6 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOO25289.1 - 0.0037 16.9 0.4 0.0037 16.9 0.4 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KOO25289.1 - 0.017 14.4 0.3 0.031 13.5 0.3 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO25289.1 - 0.041 14.4 0.2 0.16 12.6 0.2 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase LRR_6 PF13516.6 KOO25290.1 - 5.3e-09 35.4 6.6 0.29 11.3 0.0 6.1 7 0 0 7 7 7 4 Leucine Rich repeat Branch PF02485.21 KOO25293.1 - 2.5e-18 66.5 0.0 7.1e-11 42.1 0.0 2.1 1 1 1 2 2 2 2 Core-2/I-Branching enzyme Kinesin PF00225.23 KOO25294.1 - 2.3e-96 322.6 0.0 5.8e-96 321.3 0.0 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO25294.1 - 4.7e-51 172.6 0.0 1.1e-50 171.4 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding FAM76 PF16046.5 KOO25294.1 - 0.011 15.1 24.1 0.016 14.6 10.3 2.4 2 0 0 2 2 2 0 FAM76 protein ABC_tran PF00005.27 KOO25295.1 - 8e-49 165.7 0.0 1.6e-27 96.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO25295.1 - 9e-22 78.2 3.3 2.4e-06 27.6 0.5 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO25295.1 - 2.3e-10 40.3 0.3 0.082 12.3 0.0 4.1 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain ABC_tran_Xtn PF12848.7 KOO25295.1 - 5.9e-09 35.8 0.6 1.6e-08 34.4 0.5 1.7 2 0 0 2 2 1 1 ABC transporter AAA_29 PF13555.6 KOO25295.1 - 3.8e-08 33.0 0.0 0.0032 17.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO25295.1 - 9e-08 32.2 0.0 0.0035 17.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 KOO25295.1 - 1.1e-07 32.5 0.0 0.0024 18.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 KOO25295.1 - 1e-06 28.8 0.1 0.075 13.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 KOO25295.1 - 1.7e-05 25.3 5.0 0.066 13.6 0.1 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA_15 PF13175.6 KOO25295.1 - 3.4e-05 23.7 0.3 0.27 10.9 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain MeaB PF03308.16 KOO25295.1 - 4.3e-05 22.6 0.1 0.0081 15.2 0.0 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 KOO25295.1 - 5.7e-05 22.9 0.0 0.11 12.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 KOO25295.1 - 6.7e-05 23.0 0.2 0.28 11.2 0.0 2.5 2 0 0 2 2 2 2 Dynamin family AAA_33 PF13671.6 KOO25295.1 - 7.2e-05 23.0 0.8 0.49 10.6 0.0 2.8 3 1 0 3 3 2 2 AAA domain AAA_27 PF13514.6 KOO25295.1 - 7.5e-05 22.4 0.5 0.064 12.8 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 KOO25295.1 - 0.00016 21.9 0.0 0.13 12.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOO25295.1 - 0.00022 21.8 0.0 0.025 15.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 KOO25295.1 - 0.00025 21.2 2.0 0.48 10.7 0.2 3.8 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 KOO25295.1 - 0.0012 19.1 1.0 0.31 11.3 0.0 2.9 3 1 0 3 3 2 1 AAA domain NACHT PF05729.12 KOO25295.1 - 0.0013 18.6 0.8 1.3 8.9 0.0 2.5 2 0 0 2 2 2 2 NACHT domain Roc PF08477.13 KOO25295.1 - 0.0014 18.8 0.2 0.5 10.6 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Zeta_toxin PF06414.12 KOO25295.1 - 0.0028 17.0 1.7 0.69 9.2 0.1 2.5 3 0 0 3 3 2 1 Zeta toxin Mg_chelatase PF01078.21 KOO25295.1 - 0.0035 16.7 0.1 2.4 7.5 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KOO25295.1 - 0.0058 17.0 0.1 5.1 7.5 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 KOO25295.1 - 0.0094 16.4 0.1 4.6 7.7 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 KOO25295.1 - 0.022 13.9 0.3 0.48 9.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATP_bind_1 PF03029.17 KOO25295.1 - 0.022 14.5 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 KOO25295.1 - 0.024 14.2 0.0 4.2 6.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 KOO25295.1 - 0.029 14.0 0.9 3.4 7.2 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 KOO25295.1 - 0.029 13.9 1.1 3.9 7.0 0.1 2.8 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.25 KOO25295.1 - 0.047 13.4 0.0 0.96 9.1 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_5 PF07728.14 KOO25295.1 - 0.051 13.6 0.0 7.5 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 KOO25295.1 - 0.056 13.9 0.9 0.61 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 KOO25295.1 - 0.057 13.2 0.2 2.3 7.9 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MukB PF04310.12 KOO25295.1 - 0.079 12.8 0.1 4.5 7.0 0.1 2.3 2 0 0 2 2 2 0 MukB N-terminal TsaE PF02367.17 KOO25295.1 - 0.092 12.8 0.1 10 6.1 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FtsK_SpoIIIE PF01580.18 KOO25295.1 - 0.1 11.9 0.1 9.9 5.4 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family IstB_IS21 PF01695.17 KOO25295.1 - 0.1 12.3 0.2 9.7 5.9 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 KOO25295.1 - 0.11 12.2 5.5 1.7 8.3 0.0 3.3 4 0 0 4 4 3 0 AAA domain NB-ARC PF00931.22 KOO25295.1 - 0.11 11.6 0.0 1.5 7.9 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Guanylate_kin PF00625.21 KOO25295.1 - 0.17 11.6 0.0 22 4.7 0.0 2.2 2 0 0 2 2 2 0 Guanylate kinase FeoB_N PF02421.18 KOO25295.1 - 0.18 11.3 0.4 9.2 5.8 0.0 2.5 3 0 0 3 3 2 0 Ferrous iron transport protein B Pkinase PF00069.25 KOO25297.1 - 5.2e-56 189.9 0.0 6e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25297.1 - 2.3e-24 86.1 0.0 3e-24 85.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO25297.1 - 1.9e-09 37.3 0.0 2.9e-09 36.7 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO25297.1 - 0.00072 18.4 0.0 0.00092 18.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO25297.1 - 0.039 13.3 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aldo_ket_red PF00248.21 KOO25298.1 - 6e-53 179.9 0.0 2.8e-52 177.7 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family Ku PF02735.16 KOO25300.1 - 1.2e-32 113.3 0.0 1.7e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 KOO25300.1 - 4.9e-26 91.8 0.0 2.1e-25 89.8 0.0 1.8 1 1 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain SAP PF02037.27 KOO25300.1 - 1.2e-08 34.5 0.0 2.3e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 SAP domain Ku_C PF03730.14 KOO25300.1 - 0.011 16.4 0.0 0.029 15.1 0.0 1.6 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm CobA_CobO_BtuR PF02572.15 KOO25300.1 - 0.13 12.5 0.1 0.24 11.6 0.1 1.3 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP GNAT_like PF18407.1 KOO25301.1 - 1.4 9.3 17.2 3.6 8.0 8.9 2.8 2 0 0 2 2 2 0 GCN5-related N-acetyltransferase like domain Redoxin PF08534.10 KOO25302.1 - 1.3e-05 25.0 0.0 2.5e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Redoxin Thioredoxin PF00085.20 KOO25303.1 - 1.2e-15 57.3 0.0 1.5e-15 57.0 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KOO25303.1 - 0.0041 16.5 0.0 0.0043 16.4 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family P34-Arc PF04045.14 KOO25303.1 - 0.12 12.1 0.1 0.12 12.1 0.1 1.0 1 0 0 1 1 1 0 Arp2/3 complex, 34 kD subunit p34-Arc LrgB PF04172.16 KOO25304.1 - 1.9e-38 132.2 16.4 1.9e-38 132.2 16.4 1.7 2 0 0 2 2 2 1 LrgB-like family LrgA PF03788.14 KOO25304.1 - 8.1e-06 25.7 7.0 8.1e-06 25.7 7.0 3.1 3 0 0 3 3 3 1 LrgA family PX PF00787.24 KOO25305.1 - 4.1e-06 26.8 0.0 7.4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 PX domain RNA_pol_Rpb1_5 PF04998.17 KOO25306.1 - 3.7e-83 279.0 0.0 4.9e-83 278.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KOO25306.1 - 1e-50 172.2 0.0 2.1e-50 171.2 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 KOO25306.1 - 4.6e-33 114.4 0.0 1.1e-32 113.2 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KOO25306.1 - 8.1e-17 61.1 0.0 1.6e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 MIP-T3_C PF17749.1 KOO25307.1 - 5.3e-35 120.7 0.3 9e-35 119.9 0.3 1.3 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 C-terminal region MIP-T3 PF10243.9 KOO25307.1 - 2.8e-33 114.3 0.0 4.7e-19 68.4 0.0 2.6 2 0 0 2 2 2 2 Microtubule-binding protein MIP-T3 CH-like domain Lebercilin PF15619.6 KOO25307.1 - 0.035 13.8 1.4 0.063 12.9 1.4 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease K-box PF01486.17 KOO25307.1 - 0.042 14.0 1.3 0.082 13.1 1.3 1.5 1 0 0 1 1 1 0 K-box region DUF3142 PF11340.8 KOO25307.1 - 0.046 13.6 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) CENP-F_leu_zip PF10473.9 KOO25307.1 - 0.059 13.4 1.5 0.13 12.3 1.5 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 KOO25307.1 - 0.49 9.2 2.3 0.85 8.4 2.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein HMG_box PF00505.19 KOO25308.1 - 1e-20 73.9 0.2 2.3e-20 72.8 0.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO25308.1 - 8.4e-11 42.3 0.1 1.6e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 HMG-box domain MMTV_SAg PF01054.17 KOO25308.1 - 0.1 12.1 0.2 0.15 11.6 0.2 1.2 1 0 0 1 1 1 0 Mouse mammary tumour virus superantigen EF-hand_7 PF13499.6 KOO25309.1 - 1.7e-10 41.2 3.3 5.3e-06 26.8 0.3 2.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO25309.1 - 2.5e-07 30.1 0.5 0.0083 16.0 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO25309.1 - 1.1e-06 27.7 2.5 0.0099 15.4 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO25309.1 - 3.3e-05 23.2 5.9 0.038 13.5 0.4 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO25309.1 - 0.04 13.8 0.9 4.4 7.2 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair Cation_ATPase_C PF00689.21 KOO25310.1 - 6.2e-18 65.1 2.0 8.5e-18 64.7 2.0 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus EF-hand_6 PF13405.6 KOO25311.1 - 0.00043 20.0 0.1 0.00097 18.9 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO25311.1 - 0.00077 18.8 0.1 0.0016 17.8 0.1 1.6 1 0 0 1 1 1 1 EF hand Med7 PF05983.11 KOO25311.1 - 0.03 14.4 0.1 0.052 13.6 0.1 1.3 1 0 0 1 1 1 0 MED7 protein EF-hand_7 PF13499.6 KOO25311.1 - 0.031 14.7 0.1 0.077 13.5 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair Nop14 PF04147.12 KOO25311.1 - 0.25 9.5 3.6 0.35 9.0 3.6 1.1 1 0 0 1 1 1 0 Nop14-like family Draxin PF15550.6 KOO25312.1 - 0.52 10.1 9.4 0.92 9.3 9.4 1.3 1 0 0 1 1 1 0 Draxin HAUS5 PF14817.6 KOO25312.1 - 1.4 7.6 8.5 2.1 7.0 8.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 DNMT1-RFD PF12047.8 KOO25312.1 - 3 7.9 7.0 0.34 10.9 0.2 2.7 4 0 0 4 4 4 0 Cytosine specific DNA methyltransferase replication foci domain zf-C3HC4_3 PF13920.6 KOO25313.1 - 0.046 13.6 0.3 0.13 12.2 0.3 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO25313.1 - 0.055 13.8 0.7 0.12 12.7 0.7 1.6 1 0 0 1 1 1 0 Ring finger domain RhoGEF PF00621.20 KOO25314.1 - 1.1e-39 136.6 0.0 1.8e-39 135.9 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain WW PF00397.26 KOO25314.1 - 1.3e-11 44.4 0.5 7.2e-05 22.8 0.0 2.5 2 0 0 2 2 2 2 WW domain PH PF00169.29 KOO25314.1 - 2.1e-11 44.2 0.0 2.4e-09 37.6 0.0 2.7 2 1 0 2 2 2 1 PH domain PH_6 PF15406.6 KOO25314.1 - 0.018 15.3 0.0 0.071 13.4 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain PH_13 PF16652.5 KOO25314.1 - 0.026 14.3 3.0 0.36 10.6 0.2 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain PmbA_TldD PF01523.16 KOO25314.1 - 0.076 12.9 1.3 2.9 7.7 0.0 2.9 3 0 0 3 3 3 0 Putative modulator of DNA gyrase TTL PF03133.15 KOO25315.1 - 9.4e-60 202.2 0.0 1.2e-59 201.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO25315.1 - 7e-08 32.0 0.0 2.4e-05 23.7 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO25315.1 - 0.082 12.1 0.0 0.37 10.0 0.0 1.8 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp CRAL_TRIO PF00650.20 KOO25316.1 - 6.6e-18 64.9 0.0 1.1e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain DUF1769 PF08588.10 KOO25316.1 - 0.0006 20.0 0.0 0.0018 18.5 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1769) CRAL_TRIO_2 PF13716.6 KOO25316.1 - 0.0043 17.2 0.0 0.0072 16.5 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF747 PF05346.11 KOO25317.1 - 3.1e-97 325.9 4.3 4.6e-97 325.3 4.3 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family TRAM_LAG1_CLN8 PF03798.16 KOO25317.1 - 5.5e-06 26.3 8.1 5.5e-06 26.3 8.1 2.9 2 1 0 2 2 2 1 TLC domain FGGY_C PF02782.16 KOO25318.1 - 9.6e-12 45.0 0.0 1.8e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 KOO25318.1 - 1.3e-05 24.9 0.0 1.8e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain zf-CW PF07496.15 KOO25319.1 - 1.1e-12 47.8 11.6 2.7e-12 46.5 11.6 1.8 1 0 0 1 1 1 1 CW-type Zinc Finger SET PF00856.28 KOO25319.1 - 5.7e-07 30.1 0.0 3.7e-06 27.4 0.0 2.3 2 2 0 2 2 2 1 SET domain Thioredoxin PF00085.20 KOO25320.1 - 4e-32 110.3 0.0 5.5e-30 103.4 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.13 KOO25320.1 - 5.8e-07 29.2 0.0 0.00036 20.0 0.0 2.1 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KOO25320.1 - 9.9e-05 22.8 0.1 0.001 19.5 0.1 2.4 2 1 0 2 2 2 1 Thioredoxin-like domain Calsequestrin PF01216.17 KOO25320.1 - 0.00032 19.9 0.0 0.00051 19.2 0.0 1.3 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_7 PF13899.6 KOO25320.1 - 0.0052 16.9 0.0 0.0093 16.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Kelch_6 PF13964.6 KOO25320.1 - 0.0093 16.2 0.4 0.033 14.5 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 KOO25320.1 - 0.044 13.8 0.5 0.08 13.0 0.5 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain Thioredoxin_8 PF13905.6 KOO25320.1 - 0.059 13.7 0.0 1.8 9.0 0.0 2.3 1 1 1 2 2 2 0 Thioredoxin-like Hist_deacetyl PF00850.19 KOO25321.1 - 1.4e-71 241.5 0.0 1.4e-71 241.5 0.0 1.7 2 0 0 2 2 2 1 Histone deacetylase domain 60KD_IMP PF02096.20 KOO25322.1 - 6.7e-25 87.9 0.0 8.5e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein Cwf_Cwc_15 PF04889.12 KOO25324.1 - 2.7e-39 135.4 5.3 3e-39 135.3 5.3 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein HEAT PF02985.22 KOO25325.1 - 3.4e-09 36.2 17.0 0.0071 16.5 0.1 6.6 6 0 0 6 6 6 3 HEAT repeat Arm PF00514.23 KOO25325.1 - 1.4e-08 34.5 24.3 0.033 14.3 0.5 7.2 6 1 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO25325.1 - 2.7e-08 34.1 18.2 0.0062 16.9 0.8 5.6 5 2 1 7 7 7 4 HEAT repeats Cnd1 PF12717.7 KOO25325.1 - 1e-06 28.9 0.2 0.04 14.0 0.0 2.4 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 RICTOR_V PF14668.6 KOO25325.1 - 0.00044 20.4 1.7 0.027 14.7 0.1 2.7 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 Adaptin_N PF01602.20 KOO25325.1 - 0.0012 17.5 1.0 0.013 14.1 0.8 2.5 1 1 0 1 1 1 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 KOO25325.1 - 0.049 13.8 0.5 52 4.0 0.1 4.3 5 0 0 5 5 5 0 V-ATPase subunit H HEAT_EZ PF13513.6 KOO25325.1 - 0.081 13.5 23.5 0.25 11.9 0.6 5.9 5 3 3 8 8 8 0 HEAT-like repeat DUF760 PF05542.11 KOO25327.1 - 2.7e-27 94.9 1.2 3.2e-15 56.3 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF760) EF-hand_7 PF13499.6 KOO25327.1 - 1.3e-13 51.1 0.0 3.5e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO25327.1 - 1.6e-12 46.0 0.0 5.3e-05 22.5 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO25327.1 - 1.1e-10 40.6 0.0 0.00018 21.2 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO25327.1 - 1.9e-08 33.5 0.0 0.0022 17.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO25327.1 - 1.7e-07 31.0 0.0 0.0013 18.5 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain pair DUF2442 PF10387.9 KOO25327.1 - 0.18 12.1 0.0 0.61 10.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2442) FAD_binding_3 PF01494.19 KOO25329.1 - 4e-09 36.2 0.6 5.9e-09 35.6 0.6 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOO25329.1 - 9.3e-07 28.7 0.1 1.5e-06 28.1 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOO25329.1 - 1.1e-06 27.6 0.1 1.5e-06 27.2 0.1 1.1 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 KOO25329.1 - 1.2e-06 28.0 0.0 3.1e-06 26.6 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO25329.1 - 3.3e-06 26.5 0.5 5.1e-06 25.8 0.2 1.4 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 KOO25329.1 - 7.9e-06 26.0 0.1 7.9e-06 26.0 0.1 2.3 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOO25329.1 - 3e-05 23.4 0.0 4.4e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOO25329.1 - 3.5e-05 23.2 0.2 5e-05 22.7 0.2 1.1 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 KOO25329.1 - 6.2e-05 22.5 0.5 9.3e-05 21.9 0.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOO25329.1 - 9.5e-05 22.9 0.2 0.00018 22.0 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOO25329.1 - 0.00012 21.4 0.3 0.00015 20.9 0.3 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A ApbA PF02558.16 KOO25329.1 - 0.00048 19.8 0.1 0.00075 19.2 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Glu_dehyd_C PF16912.5 KOO25329.1 - 0.00068 19.2 0.0 0.00098 18.7 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 KOO25329.1 - 0.002 17.4 0.7 0.0031 16.9 0.7 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.21 KOO25329.1 - 0.0066 15.8 0.8 0.0095 15.3 0.8 1.1 1 0 0 1 1 1 1 ThiF family Lycopene_cycl PF05834.12 KOO25329.1 - 0.017 14.2 0.1 0.031 13.3 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 KOO25329.1 - 0.041 14.3 0.1 0.078 13.4 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 KOO25329.1 - 0.051 12.4 0.1 0.068 12.0 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase 3HCDH_N PF02737.18 KOO25329.1 - 0.068 13.0 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amino_oxidase PF01593.24 KOO25329.1 - 0.072 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase WD40 PF00400.32 KOO25331.1 - 7.7e-70 229.1 10.7 4.6e-09 36.8 0.0 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO25331.1 - 7.3e-17 61.5 0.5 0.0048 17.2 0.0 6.7 1 1 7 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOO25331.1 - 1.3e-09 37.8 0.5 0.033 13.5 0.1 5.5 3 1 1 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 KOO25331.1 - 3.9e-09 35.9 9.0 0.014 14.4 1.3 6.0 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOO25331.1 - 3.8e-07 30.2 1.3 0.13 12.1 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOO25331.1 - 8.1e-06 24.8 11.5 0.43 9.2 0.0 6.3 2 2 5 7 7 7 3 Nucleoporin Nup120/160 WD40_3 PF15911.5 KOO25331.1 - 5.9e-05 23.0 0.5 0.027 14.4 0.0 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat Nucleoporin_N PF08801.11 KOO25331.1 - 0.0026 16.5 0.1 1.3 7.7 0.0 3.4 2 1 0 3 3 3 1 Nup133 N terminal like YabP PF07873.11 KOO25331.1 - 0.15 11.9 0.1 1e+02 2.8 0.0 3.9 4 0 0 4 4 4 0 YabP family DUF5114 PF17141.4 KOO25331.1 - 0.37 11.4 3.1 3.9 8.1 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5114) DUF5570 PF17731.1 KOO25331.1 - 0.86 9.7 10.0 1.3 9.1 0.5 4.0 1 1 3 4 4 4 0 Family of unknown function (DUF5570) Seryl_tRNA_N PF02403.22 KOO25332.1 - 1.7e-22 79.7 3.0 2.6e-22 79.1 3.0 1.2 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain AAA PF00004.29 KOO25333.1 - 2.8e-42 144.2 0.1 9.8e-42 142.5 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO25333.1 - 2.5e-10 40.0 0.2 5.2e-10 39.0 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KOO25333.1 - 3.9e-07 29.9 0.5 8.8e-07 28.8 0.5 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 KOO25333.1 - 4.8e-06 26.8 0.0 9.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KOO25333.1 - 4.6e-05 23.4 0.0 0.00021 21.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO25333.1 - 8.2e-05 23.0 2.1 0.00066 20.1 0.5 3.0 2 1 0 2 2 1 1 AAA ATPase domain RuvB_N PF05496.12 KOO25333.1 - 9.4e-05 22.2 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOO25333.1 - 0.00026 21.3 0.2 0.034 14.4 0.2 2.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO25333.1 - 0.00039 20.6 0.0 0.0012 19.0 0.0 2.0 1 1 0 2 2 1 1 AAA domain DUF2072 PF09845.9 KOO25333.1 - 0.0024 18.1 0.1 0.0065 16.7 0.1 1.7 1 0 0 1 1 1 1 Zn-ribbon containing protein Mg_chelatase PF01078.21 KOO25333.1 - 0.0041 16.5 0.1 0.0087 15.5 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.16 KOO25333.1 - 0.0056 16.2 0.1 0.095 12.1 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein IstB_IS21 PF01695.17 KOO25333.1 - 0.0059 16.4 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 KOO25333.1 - 0.0063 15.8 0.0 0.012 14.8 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_3 PF07726.11 KOO25333.1 - 0.0066 16.3 0.0 0.028 14.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOO25333.1 - 0.016 14.9 0.0 0.11 12.1 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.6 KOO25333.1 - 0.018 15.6 0.1 0.075 13.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KOO25333.1 - 0.026 14.8 0.0 0.057 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KOO25333.1 - 0.029 13.7 0.0 0.13 11.6 0.0 2.0 2 0 0 2 2 2 0 KaiC AAA_17 PF13207.6 KOO25333.1 - 0.038 14.4 0.0 0.13 12.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KOO25333.1 - 0.052 12.8 0.0 0.17 11.1 0.0 1.9 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 KOO25333.1 - 0.062 13.1 0.2 0.29 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KOO25333.1 - 0.062 12.8 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 KOO25333.1 - 0.065 12.9 0.1 0.14 11.9 0.1 1.8 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 KOO25333.1 - 0.073 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 KOO25333.1 - 0.076 13.4 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.17 KOO25333.1 - 0.076 12.1 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 LRR_4 PF12799.7 KOO25334.1 - 2.5e-15 56.3 37.9 0.00024 21.4 1.0 7.9 6 1 1 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO25334.1 - 8.7e-15 54.2 45.8 6.6e-08 32.2 6.8 8.6 5 3 2 7 7 7 4 Leucine rich repeat Roc PF08477.13 KOO25334.1 - 1.2e-09 38.4 0.0 2.3e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_6 PF13516.6 KOO25334.1 - 3.8e-08 32.8 70.7 0.0056 16.6 0.9 15.7 19 0 0 19 19 18 6 Leucine Rich repeat ART PF01129.18 KOO25334.1 - 5.9e-05 22.5 0.0 0.00015 21.1 0.0 1.6 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase Ras PF00071.22 KOO25334.1 - 0.00039 20.0 0.0 0.00081 19.0 0.0 1.5 1 0 0 1 1 1 1 Ras family COR PF16095.5 KOO25334.1 - 0.0015 18.4 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain NACHT PF05729.12 KOO25334.1 - 0.003 17.5 0.3 0.0098 15.8 0.0 2.0 2 0 0 2 2 2 1 NACHT domain ADPrib_exo_Tox PF03496.14 KOO25334.1 - 0.0042 16.5 0.0 0.018 14.4 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme LRR_1 PF00560.33 KOO25334.1 - 0.029 14.9 34.9 17 6.4 0.3 11.7 13 0 0 13 13 13 0 Leucine Rich Repeat Arf PF00025.21 KOO25334.1 - 0.079 12.4 0.0 0.41 10.1 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family LRR_9 PF14580.6 KOO25334.1 - 0.6 9.6 3.2 0.51 9.8 0.4 2.4 2 0 0 2 2 2 0 Leucine-rich repeat EF-hand_1 PF00036.32 KOO25338.1 - 4.7e-11 41.4 0.2 0.0001 21.6 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO25338.1 - 1.3e-10 40.4 0.0 0.00057 19.6 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO25338.1 - 2.8e-08 34.1 0.2 6.9e-08 32.8 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO25338.1 - 2.1e-06 27.0 0.8 0.0053 16.2 0.1 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO25338.1 - 1.6e-05 24.6 0.3 0.0053 16.6 0.2 2.9 3 0 0 3 3 3 2 EF-hand domain pair Metallophos PF00149.28 KOO25338.1 - 0.0057 17.2 0.0 0.024 15.1 0.0 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Arm PF00514.23 KOO25339.1 - 1.2e-67 222.1 60.7 2.7e-07 30.4 0.0 15.0 16 0 0 16 16 16 14 Armadillo/beta-catenin-like repeat PARP PF00644.20 KOO25339.1 - 1.8e-14 53.8 0.0 3e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Nucleoporin_FG PF13634.6 KOO25339.1 - 3.2e-06 27.9 13.2 0.029 15.2 1.8 3.9 2 2 0 2 2 2 2 Nucleoporin FG repeat region WWE PF02825.20 KOO25339.1 - 3.7e-05 24.2 0.0 5.9e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 WWE domain Arm_2 PF04826.13 KOO25339.1 - 0.0033 16.9 0.1 34 3.8 0.0 5.0 3 2 1 5 5 5 1 Armadillo-like WD40 PF00400.32 KOO25340.1 - 7.4e-29 99.4 9.3 1.8e-07 31.7 0.1 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO25340.1 - 1.7e-10 41.1 0.1 0.044 14.1 0.1 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KOO25340.1 - 0.00076 19.9 4.2 5 7.7 0.0 5.7 5 1 0 5 5 5 1 PQQ-like domain Nucleoporin_N PF08801.11 KOO25340.1 - 0.0093 14.7 0.0 0.55 8.9 0.0 2.9 4 0 0 4 4 4 1 Nup133 N terminal like Nup160 PF11715.8 KOO25340.1 - 0.022 13.4 0.3 20 3.6 0.0 4.1 3 2 0 5 5 5 0 Nucleoporin Nup120/160 WD40_like PF17005.5 KOO25340.1 - 0.025 13.9 0.0 1.4 8.2 0.0 2.7 3 0 0 3 3 3 0 WD40-like domain PQQ_2 PF13360.6 KOO25340.1 - 0.028 14.0 0.8 0.5 9.9 0.1 2.8 1 1 0 1 1 1 0 PQQ-like domain Peptidase_M24 PF00557.24 KOO25341.1 - 1.3e-41 142.6 0.0 2e-41 142.0 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Nop53 PF07767.11 KOO25341.1 - 4.6 6.5 8.6 5.9 6.2 7.6 1.6 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) IQ PF00612.27 KOO25342.1 - 4.4e-07 29.1 9.6 0.09 12.6 0.2 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif DUF572 PF04502.13 KOO25342.1 - 9.5 5.7 19.6 13 5.3 19.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) NAD_binding_10 PF13460.6 KOO25343.1 - 2.4e-12 47.1 0.0 4.4e-12 46.3 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOO25343.1 - 2e-08 34.0 0.0 1.3e-07 31.4 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO25343.1 - 0.0002 20.4 0.0 0.00032 19.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 KOO25343.1 - 0.025 14.8 0.0 0.055 13.7 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 KOO25343.1 - 0.062 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family KR PF08659.10 KOO25343.1 - 0.068 13.1 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 KR domain Cupin_8 PF13621.6 KOO25344.1 - 6.9e-28 98.0 0.0 1.5e-25 90.3 0.1 2.2 2 0 0 2 2 2 2 Cupin-like domain Cupin_4 PF08007.12 KOO25344.1 - 0.0028 17.2 0.1 0.061 12.8 0.0 2.6 2 1 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 KOO25344.1 - 0.0045 17.4 0.0 0.015 15.7 0.0 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase DUF3586 PF12131.8 KOO25344.1 - 0.5 10.6 0.1 0.5 10.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3586) TolA_bind_tri PF16331.5 KOO25345.1 - 0.032 14.3 9.1 1.4 9.1 1.7 2.6 2 0 0 2 2 2 0 TolA binding protein trimerisation Collagen_mid PF15984.5 KOO25345.1 - 0.034 13.9 1.4 0.49 10.1 0.2 2.1 2 0 0 2 2 2 0 Bacterial collagen, middle region FlaC_arch PF05377.11 KOO25345.1 - 0.13 12.7 0.5 20 5.7 0.1 3.6 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF5446 PF17522.2 KOO25345.1 - 0.17 12.1 0.5 0.61 10.3 0.5 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5446) Glyco_hyd_65N_2 PF14498.6 KOO25345.1 - 0.17 11.7 0.2 0.35 10.7 0.2 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain HemX PF04375.14 KOO25345.1 - 0.2 10.9 5.6 0.14 11.4 1.9 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2730 PF10805.8 KOO25345.1 - 0.26 11.4 1.1 7.6 6.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) CENP-F_leu_zip PF10473.9 KOO25345.1 - 0.44 10.6 9.9 4.5 7.3 0.2 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 KOO25345.1 - 2.1 7.2 6.1 7.4 5.3 6.1 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein DNA_pol_A_exo1 PF01612.20 KOO25346.1 - 6.4e-13 48.8 0.0 1.1e-11 44.8 0.0 2.0 1 1 0 1 1 1 1 3'-5' exonuclease Gly-zipper_Omp PF13488.6 KOO25346.1 - 0.024 14.6 9.9 0.052 13.6 9.9 1.5 1 0 0 1 1 1 0 Glycine zipper TMEM65 PF10507.9 KOO25346.1 - 0.072 13.0 0.1 1.3 9.0 0.0 2.1 1 1 1 2 2 2 0 Transmembrane protein 65 DUF3482 PF11981.8 KOO25346.1 - 0.31 10.4 1.4 0.38 10.1 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Filamin PF00630.19 KOO25347.1 - 0.005 17.6 0.0 0.0089 16.8 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat DUF3037 PF11236.8 KOO25347.1 - 1.5 9.3 4.8 1.3 9.5 1.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3037) CPSase_L_D2 PF02786.17 KOO25349.1 - 2.5e-65 220.0 0.0 3.9e-65 219.3 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KOO25349.1 - 5.4e-44 149.2 1.8 1.7e-43 147.7 0.1 2.5 3 0 0 3 3 3 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOO25349.1 - 2.7e-30 104.6 0.0 3.7e-20 72.0 0.0 3.3 3 0 0 3 3 3 2 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KOO25349.1 - 1.7e-13 50.1 0.1 3.9e-13 49.0 0.1 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 KOO25349.1 - 1.9e-07 30.8 0.0 3.8e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 KOO25349.1 - 1.1e-06 28.4 0.2 2.8e-06 27.1 0.2 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD_3 PF13437.6 KOO25349.1 - 0.00017 22.3 0.8 0.61 10.8 0.1 3.2 3 0 0 3 3 3 2 HlyD family secretion protein ATP-grasp PF02222.22 KOO25349.1 - 0.00081 19.0 0.0 0.002 17.7 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 KOO25349.1 - 0.02 14.1 0.1 0.073 12.3 0.0 1.8 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Cytochrom_B561 PF03188.16 KOO25350.1 - 0.0016 18.6 1.4 0.0033 17.6 0.2 1.9 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 SdpI PF13630.6 KOO25350.1 - 0.002 18.2 0.5 0.002 18.2 0.5 3.2 3 1 0 3 3 3 2 SdpI/YhfL protein family COX15-CtaA PF02628.15 KOO25350.1 - 0.0044 16.2 1.3 0.59 9.2 0.0 2.2 2 0 0 2 2 2 2 Cytochrome oxidase assembly protein DUF4079 PF13301.6 KOO25350.1 - 0.06 13.5 0.9 0.21 11.7 0.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) DUF2427 PF10348.9 KOO25350.1 - 1.5 8.7 10.2 5 7.0 0.5 3.2 2 1 2 4 4 4 0 Domain of unknown function (DUF2427) Peptidase_S8 PF00082.22 KOO25351.1 - 3.7e-78 262.8 0.2 5.3e-78 262.3 0.2 1.2 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 KOO25351.1 - 1.5e-39 135.5 0.0 6.1e-39 133.5 0.0 1.8 2 0 0 2 2 2 1 Tripeptidyl peptidase II IMPDH PF00478.25 KOO25352.1 - 5.9e-133 443.1 1.9 6.9e-133 442.9 1.9 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 KOO25352.1 - 8.6e-17 61.3 0.0 8.6e-09 35.7 0.0 2.7 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 KOO25352.1 - 1.4e-09 37.8 0.3 8.4e-06 25.4 0.9 2.4 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 KOO25352.1 - 6.9e-08 31.9 0.7 5.3e-07 29.0 1.1 2.1 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 KOO25352.1 - 1.8e-05 24.3 0.1 0.0012 18.4 0.0 2.4 1 1 1 2 2 2 1 Histidine biosynthesis protein NanE PF04131.14 KOO25352.1 - 0.014 14.5 0.1 0.038 13.2 0.1 1.8 1 1 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase YpsA PF06908.11 KOO25352.1 - 0.027 14.5 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family B12-binding PF02310.19 KOO25352.1 - 0.13 12.3 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 B12 binding domain PseudoU_synth_2 PF00849.22 KOO25353.1 - 8.4e-26 91.0 0.0 1.2e-25 90.5 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Senescence_reg PF04520.13 KOO25354.1 - 0.13 13.1 3.1 0.32 11.8 3.2 1.6 2 0 0 2 2 2 0 Senescence regulator Filamin PF00630.19 KOO25355.1 - 3.8e-23 82.3 0.0 2.9e-06 28.0 0.0 5.7 5 1 0 5 5 5 5 Filamin/ABP280 repeat C2 PF00168.30 KOO25355.1 - 2.8e-12 46.8 0.0 6.2e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 C2 domain Invasin_D3 PF09134.10 KOO25355.1 - 7.9e-07 29.3 0.1 0.012 15.9 0.0 4.5 4 0 0 4 4 4 1 Invasin, domain 3 Big_1 PF02369.16 KOO25355.1 - 0.0017 18.3 0.1 1 9.4 0.0 3.5 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 1) Y_Y_Y PF07495.13 KOO25355.1 - 0.019 14.9 0.0 5.7 7.0 0.0 3.1 3 0 0 3 3 3 0 Y_Y_Y domain HSP70 PF00012.20 KOO25356.1 - 8.5e-233 773.9 0.4 9.7e-233 773.7 0.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOO25356.1 - 7.4e-16 57.9 0.7 3.5e-15 55.6 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 KOO25356.1 - 0.0002 21.7 0.4 0.62 10.5 0.1 3.6 3 2 0 3 3 3 2 Cell division protein FtsA HMG-CoA_red PF00368.18 KOO25356.1 - 0.15 11.0 0.3 6.5 5.7 0.1 2.2 2 0 0 2 2 2 0 Hydroxymethylglutaryl-coenzyme A reductase Beach PF02138.18 KOO25357.1 - 3.8e-98 328.3 0.0 4.9e-98 327.9 0.0 1.1 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 KOO25357.1 - 2.1e-07 30.9 0.0 1.9e-05 24.7 0.0 3.1 3 0 0 3 3 3 1 PH domain associated with Beige/BEACH zf-C3HC4 PF00097.25 KOO25358.1 - 2e-08 34.0 7.3 2e-08 34.0 7.3 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO25358.1 - 3e-08 33.9 7.6 3e-08 33.9 7.6 3.2 4 0 0 4 4 2 1 Ring finger domain Prok-RING_4 PF14447.6 KOO25358.1 - 4.8e-06 26.3 4.7 4.8e-06 26.3 4.7 2.7 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KOO25358.1 - 9.2e-06 25.4 2.9 9.2e-06 25.4 2.9 3.4 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO25358.1 - 1.5e-05 24.7 5.7 1.5e-05 24.7 5.7 2.9 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO25358.1 - 5.3e-05 23.2 4.5 5.3e-05 23.2 4.5 2.1 2 0 0 2 2 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KOO25358.1 - 0.00011 22.4 4.1 0.00011 22.4 4.1 2.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOO25358.1 - 0.0018 18.3 2.9 0.01 15.9 2.9 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-primase PF09329.11 KOO25358.1 - 0.069 13.0 1.7 0.16 11.8 1.7 1.6 1 0 0 1 1 1 0 Primase zinc finger RdRP PF05183.12 KOO25358.1 - 0.098 11.3 0.4 0.23 10.1 0.2 1.6 2 0 0 2 2 2 0 RNA dependent RNA polymerase zf-RanBP PF00641.18 KOO25358.1 - 1.7 8.0 3.9 0.67 9.3 0.2 2.3 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others zf-C3HC4_4 PF15227.6 KOO25358.1 - 1.8 8.8 12.9 0.068 13.3 5.5 2.5 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 KOO25358.1 - 2.2 8.5 7.1 0.38 10.9 2.2 2.3 2 0 0 2 2 2 0 FANCL C-terminal domain DUF4207 PF13904.6 KOO25358.1 - 5.8 6.5 12.5 0.7 9.5 7.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) zf-RING_5 PF14634.6 KOO25358.1 - 8.1 6.5 15.7 0.047 13.7 5.5 2.7 3 0 0 3 3 3 0 zinc-RING finger domain Cellulase PF00150.18 KOO25359.1 - 1.1e-14 54.6 0.0 1.4e-14 54.3 0.0 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Hypoth_Ymh PF09509.10 KOO25360.1 - 0.08 12.8 0.3 0.22 11.4 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (Hypoth_ymh) DUF979 PF06166.12 KOO25361.1 - 0.0037 16.5 2.6 0.0044 16.2 2.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF979) DUF4064 PF13273.6 KOO25361.1 - 0.0055 17.0 3.4 0.021 15.1 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4064) DUF2070 PF09843.9 KOO25361.1 - 0.0066 14.8 2.2 0.0077 14.6 2.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) FeoB_associated PF12669.7 KOO25361.1 - 0.0099 16.3 2.4 0.02 15.3 2.4 1.4 1 0 0 1 1 1 1 FeoB-associated Cys-rich membrane protein Glycophorin_A PF01102.18 KOO25361.1 - 0.012 15.8 2.5 0.025 14.8 1.8 1.9 1 1 1 2 2 2 0 Glycophorin A Adeno_E3_CR2 PF02439.15 KOO25361.1 - 0.014 15.1 0.3 0.038 13.8 0.3 1.8 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF4199 PF13858.6 KOO25361.1 - 0.016 15.6 0.9 0.023 15.1 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) RCR PF12273.8 KOO25361.1 - 0.037 14.7 0.3 0.081 13.6 0.0 1.7 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red Stevor PF17410.2 KOO25361.1 - 0.072 12.6 1.7 0.094 12.2 1.7 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF2207 PF09972.9 KOO25361.1 - 0.074 11.8 0.3 0.077 11.7 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 KOO25361.1 - 0.13 13.2 0.0 0.44 11.5 0.0 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF441 PF04284.13 KOO25361.1 - 0.18 11.8 8.5 3.4 7.7 8.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF441) MtrF PF09472.10 KOO25361.1 - 3.1 7.3 7.8 0.65 9.4 2.8 2.3 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) TPR_2 PF07719.17 KOO25363.1 - 7.7e-19 66.2 15.9 0.002 18.1 0.0 7.4 8 0 0 8 8 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25363.1 - 5.9e-15 54.4 16.2 0.013 15.3 0.2 7.0 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.6 KOO25363.1 - 4.7e-14 52.7 7.2 0.0012 19.3 0.6 5.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO25363.1 - 1.1e-11 44.2 0.7 0.064 13.0 0.1 5.0 4 1 1 5 5 5 4 TPR repeat TPR_16 PF13432.6 KOO25363.1 - 1.5e-11 44.7 19.8 0.0017 19.0 0.0 5.7 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25363.1 - 3.9e-09 36.0 9.0 1.1 9.7 0.0 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25363.1 - 2.7e-08 33.6 1.0 1.1 9.8 0.0 5.7 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO25363.1 - 9.6e-08 32.2 12.5 1 10.3 1.8 6.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25363.1 - 1.2e-07 31.9 14.1 0.0066 16.7 0.9 5.4 4 1 2 6 6 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO25363.1 - 1.1e-05 25.5 4.4 0.0018 18.5 0.3 3.2 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Methyltransf_25 PF13649.6 KOO25363.1 - 4.1e-05 24.2 0.1 0.00039 21.1 0.1 2.7 2 0 0 2 2 2 1 Methyltransferase domain TPR_7 PF13176.6 KOO25363.1 - 0.00016 21.5 10.4 0.081 13.0 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO25363.1 - 0.0015 18.6 13.3 2 8.6 0.0 5.6 4 2 0 5 5 5 2 Tetratricopeptide repeat MTS PF05175.14 KOO25363.1 - 0.0021 17.6 0.2 0.0069 15.9 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase small domain BTAD PF03704.17 KOO25363.1 - 0.015 15.8 12.5 0.046 14.1 0.3 3.7 3 1 0 3 3 2 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 KOO25363.1 - 0.038 14.6 15.4 8.4 7.3 1.6 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat FAT PF02259.23 KOO25363.1 - 0.046 12.9 0.8 10 5.2 0.3 2.6 3 0 0 3 3 3 0 FAT domain Methyltransf_12 PF08242.12 KOO25363.1 - 0.061 14.1 0.2 0.94 10.3 0.1 2.8 3 0 0 3 3 2 0 Methyltransferase domain Methyltransf_24 PF13578.6 KOO25363.1 - 0.44 11.6 5.1 1.8 9.6 0.2 4.2 3 2 1 4 4 3 0 Methyltransferase domain TPR_10 PF13374.6 KOO25363.1 - 5.6 7.0 11.2 19 5.3 1.2 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat CBAH PF02275.18 KOO25364.1 - 6.4e-21 75.3 0.0 5e-14 52.7 0.0 2.2 2 0 0 2 2 2 2 Linear amide C-N hydrolases, choloylglycine hydrolase family AAA PF00004.29 KOO25365.1 - 2e-42 144.8 0.0 4.9e-42 143.5 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO25365.1 - 1.3e-06 28.9 0.7 0.00061 20.2 0.1 3.0 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KOO25365.1 - 4.3e-05 23.3 0.0 9.8e-05 22.1 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOO25365.1 - 0.00035 20.8 0.1 0.0097 16.2 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO25365.1 - 0.0014 18.8 0.0 0.0034 17.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO25365.1 - 0.0017 18.4 0.1 0.0073 16.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ATPase PF06745.13 KOO25365.1 - 0.0022 17.4 0.0 0.004 16.5 0.0 1.3 1 0 0 1 1 1 1 KaiC TIP49 PF06068.13 KOO25365.1 - 0.0023 17.2 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 KOO25365.1 - 0.004 16.9 0.1 0.0079 15.9 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 KOO25365.1 - 0.0053 16.9 0.0 0.012 15.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 KOO25365.1 - 0.012 15.0 0.5 0.035 13.5 0.5 1.7 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 KOO25365.1 - 0.025 14.1 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 KOO25365.1 - 0.037 14.0 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KOO25365.1 - 0.043 13.5 0.1 0.27 10.9 0.0 2.2 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_11 PF13086.6 KOO25365.1 - 0.055 13.2 0.0 0.094 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KOO25365.1 - 0.072 12.5 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.22 KOO25365.1 - 0.092 13.1 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 KOO25365.1 - 0.094 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOO25365.1 - 0.11 12.4 0.1 0.27 11.1 0.1 1.6 2 0 0 2 2 1 0 NACHT domain AAA_18 PF13238.6 KOO25365.1 - 0.13 12.8 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOO25365.1 - 0.18 11.9 0.0 0.27 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO25365.1 - 0.18 11.0 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.17 KOO25365.1 - 0.19 10.8 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 KOO25365.1 - 0.31 10.2 0.0 0.52 9.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 KOO25365.1 - 0.32 10.6 3.3 0.24 10.9 0.4 2.4 2 1 0 2 2 2 0 AAA domain MOZART1 PF12554.8 KOO25366.1 - 7.3e-23 80.1 0.2 1.1e-22 79.6 0.2 1.2 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated DEAD PF00270.29 KOO25367.1 - 3e-29 102.0 0.2 4.4e-29 101.5 0.2 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO25367.1 - 6.2e-12 45.9 0.0 1.7e-11 44.4 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO25367.1 - 6.5e-06 26.2 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KOO25367.1 - 0.00038 20.2 0.2 0.00067 19.4 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO25367.1 - 0.097 12.4 0.0 2.8 7.7 0.0 2.1 1 1 1 2 2 2 0 AAA domain Helicase_RecD PF05127.14 KOO25367.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Helicase Lipase_GDSL_2 PF13472.6 KOO25368.1 - 0.068 13.6 0.0 0.086 13.2 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family TAXi_C PF14541.6 KOO25369.1 - 4e-26 91.7 0.0 6e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp PF00026.23 KOO25369.1 - 2.3e-25 89.7 0.0 2.1e-18 66.8 0.0 2.0 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO25369.1 - 8.2e-25 88.1 4.0 9.3e-25 87.9 2.4 1.8 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal EF-hand_1 PF00036.32 KOO25370.1 - 0.0043 16.5 0.5 0.02 14.4 0.2 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO25370.1 - 0.0094 15.8 0.2 0.12 12.4 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain KIAA1430 PF13879.6 KOO25370.1 - 0.017 15.8 0.0 0.017 15.8 0.0 3.0 3 1 0 3 3 3 0 KIAA1430 homologue EF-hand_5 PF13202.6 KOO25370.1 - 0.072 12.6 0.4 0.23 11.0 0.4 1.8 1 0 0 1 1 1 0 EF hand dCMP_cyt_deam_1 PF00383.23 KOO25370.1 - 4.8 7.1 5.3 0.94 9.4 1.1 1.9 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region LRR_8 PF13855.6 KOO25371.1 - 8.8e-16 57.4 12.6 7.9e-09 35.1 1.9 3.1 2 1 2 4 4 4 3 Leucine rich repeat Roc PF08477.13 KOO25371.1 - 8.6e-11 42.1 0.0 1.4e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.7 KOO25371.1 - 8.1e-10 38.8 2.1 0.00011 22.5 0.4 3.3 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO25371.1 - 0.00079 19.6 2.1 6.3 7.8 0.0 4.3 4 0 0 4 4 4 2 Leucine Rich Repeat Ras PF00071.22 KOO25371.1 - 0.001 18.7 0.0 0.002 17.7 0.0 1.5 1 1 0 1 1 1 1 Ras family G-alpha PF00503.20 KOO25371.1 - 0.037 13.2 0.0 0.054 12.7 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit LRR_6 PF13516.6 KOO25371.1 - 0.62 10.3 3.0 19 5.6 0.0 3.4 3 0 0 3 3 3 0 Leucine Rich repeat Phytochelatin_C PF09328.10 KOO25372.1 - 0.15 11.4 0.3 0.23 10.8 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) Ion_trans PF00520.31 KOO25373.1 - 7.3e-13 48.3 13.6 1e-12 47.8 12.1 1.9 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO25373.1 - 7.2e-07 28.2 15.3 0.00058 18.7 12.7 2.2 2 0 0 2 2 2 2 Polycystin cation channel WD40 PF00400.32 KOO25373.1 - 1.5e-05 25.6 16.8 16 6.5 0.0 9.7 11 0 0 11 11 11 1 WD domain, G-beta repeat Ank_4 PF13637.6 KOO25373.1 - 0.0095 16.5 1.7 0.42 11.3 0.1 3.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO25373.1 - 0.013 16.1 0.2 0.035 14.7 0.2 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) DNA_ligase_A_N PF04675.14 KOO25373.1 - 0.023 15.0 0.2 0.066 13.5 0.2 1.7 1 0 0 1 1 1 0 DNA ligase N terminus WD40_like PF17005.5 KOO25373.1 - 0.052 12.9 0.0 32 3.7 0.0 3.5 4 0 0 4 4 4 0 WD40-like domain DUF707 PF05212.12 KOO25373.1 - 0.075 12.3 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF707) DAGAT PF03982.13 KOO25374.1 - 2.3e-05 23.5 0.0 3.1e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.21 KOO25374.1 - 0.00069 19.2 0.0 0.0062 16.2 0.0 2.1 1 1 0 1 1 1 1 Acyltransferase DUF3336 PF11815.8 KOO25375.1 - 1.3e-23 83.2 0.1 2.5e-23 82.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 KOO25375.1 - 1.4e-16 61.3 1.4 6.7e-15 55.8 0.0 3.1 3 0 0 3 3 3 1 Patatin-like phospholipase Phage_Coat_B PF05356.11 KOO25376.1 - 0.0073 16.2 0.1 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 Phage Coat protein B Pkinase PF00069.25 KOO25377.1 - 3.3e-59 200.4 0.0 4.7e-59 199.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25377.1 - 4.3e-27 95.0 0.0 6.6e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1741 PF08427.10 KOO25377.1 - 2.4e-19 70.0 0.0 3.9e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) Pkinase_fungal PF17667.1 KOO25377.1 - 1.7e-07 30.4 0.0 2.6e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO25377.1 - 5e-05 22.8 0.0 8.3e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO25377.1 - 0.00035 20.6 0.0 0.00035 20.6 0.0 4.3 4 2 1 5 5 5 2 Phosphotransferase enzyme family Kelch_3 PF13415.6 KOO25378.1 - 1.5e-11 44.3 0.1 0.015 15.6 0.0 4.6 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO25378.1 - 3.3e-09 36.6 3.8 0.22 11.6 0.0 5.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO25378.1 - 4.9e-09 36.0 2.8 0.019 15.0 0.0 4.9 5 0 0 5 5 5 2 Kelch motif EF-hand_6 PF13405.6 KOO25378.1 - 6.5e-08 31.9 0.4 0.00016 21.3 0.0 3.7 2 1 1 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO25378.1 - 8.9e-07 28.0 0.2 0.0012 18.2 0.0 3.1 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO25378.1 - 9.2e-06 24.9 1.1 0.005 16.3 0.1 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO25378.1 - 2.2e-05 24.8 0.0 7.5e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO25378.1 - 0.0012 18.6 0.2 0.0051 16.6 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair Kelch_6 PF13964.6 KOO25378.1 - 0.0065 16.7 0.1 3.4 8.1 0.0 4.0 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 KOO25378.1 - 0.32 11.1 2.0 0.83 9.7 0.0 2.9 4 0 0 4 4 4 0 Kelch motif HAD_SAK_2 PF18143.1 KOO25379.1 - 2.9e-26 92.5 0.0 4.2e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins EF-hand_9 PF14658.6 KOO25381.1 - 6.6e-06 26.4 0.0 0.017 15.4 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO25381.1 - 1.2e-05 25.6 0.0 0.22 12.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO25381.1 - 0.00025 20.7 0.0 0.12 12.4 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO25381.1 - 0.035 13.7 0.0 13 5.6 0.0 2.7 3 0 0 3 3 3 0 EF hand zf-RING_2 PF13639.6 KOO25382.1 - 3.7e-10 40.0 14.0 5.7e-10 39.4 14.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOO25382.1 - 5.2e-08 32.5 11.0 9e-08 31.7 11.0 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 KOO25382.1 - 3.3e-07 30.5 8.9 6.3e-07 29.6 8.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KOO25382.1 - 1e-06 28.5 12.1 1.7e-06 27.8 12.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO25382.1 - 3.7e-05 23.5 13.8 6.6e-05 22.7 13.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO25382.1 - 0.006 16.5 12.8 0.009 16.0 12.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 KOO25382.1 - 0.026 14.1 10.5 0.044 13.4 10.5 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 KOO25382.1 - 0.026 14.5 9.3 0.047 13.7 9.3 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 KOO25382.1 - 0.17 12.0 9.0 0.45 10.6 9.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 KOO25382.1 - 0.42 10.8 15.8 8.4 6.7 15.8 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 KOO25382.1 - 0.56 10.5 11.8 0.98 9.8 11.8 1.4 1 0 0 1 1 1 0 RING-like domain PHD PF00628.29 KOO25382.1 - 1.1 9.2 11.8 2.7 7.9 11.8 1.7 1 1 0 1 1 1 0 PHD-finger zf-RING_6 PF14835.6 KOO25382.1 - 2.2 8.2 8.0 4.5 7.2 8.0 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 KOO25382.1 - 4.7 7.2 14.2 7.1 6.6 14.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 KOO25382.1 - 5.3 7.2 14.9 8.7 6.6 14.9 1.3 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 KOO25382.1 - 6.9 6.6 11.2 12 5.8 11.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain EF-hand_1 PF00036.32 KOO25383.1 - 3.6e-30 101.2 22.0 4.5e-09 35.2 0.0 4.5 5 0 0 5 5 4 4 EF hand EF-hand_7 PF13499.6 KOO25383.1 - 9e-30 102.9 8.4 1.6e-16 60.5 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO25383.1 - 2.1e-25 88.3 11.3 5.5e-12 45.3 0.3 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO25383.1 - 1.7e-24 83.6 14.3 2.6e-09 36.3 0.0 5.2 4 2 2 7 7 7 4 EF-hand domain EF-hand_5 PF13202.6 KOO25383.1 - 2.4e-20 71.0 9.0 2.1e-06 27.0 0.2 5.0 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.6 KOO25383.1 - 6.1e-14 52.1 0.2 7.9e-08 32.5 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO25383.1 - 2.2e-06 27.5 3.8 0.19 11.7 0.8 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SurA_N_3 PF13624.6 KOO25383.1 - 0.00015 21.6 0.8 0.39 10.5 0.0 2.1 1 1 1 2 2 2 2 SurA N-terminal domain Caleosin PF05042.13 KOO25383.1 - 0.00042 20.3 1.0 3.6 7.5 0.0 3.6 1 1 3 4 4 4 1 Caleosin related protein SurA_N_2 PF13623.6 KOO25383.1 - 0.00086 19.2 0.7 0.9 9.4 0.0 2.3 1 1 0 2 2 2 2 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KOO25383.1 - 0.0016 18.7 0.4 0.74 10.1 0.2 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO25383.1 - 0.0035 17.6 0.6 1.5 9.2 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain SUB1_ProdP9 PF18213.1 KOO25383.1 - 0.012 15.4 1.4 0.028 14.2 0.5 2.0 1 1 1 2 2 2 0 SUB1 protease Prodomain ProdP9 DUF3008 PF11450.8 KOO25383.1 - 0.013 15.6 4.5 0.024 14.8 0.2 3.0 4 0 0 4 4 3 0 Protein of unknwon function (DUF3008) TerB PF05099.13 KOO25383.1 - 0.047 13.7 1.8 4.2 7.3 0.1 2.5 1 1 1 2 2 2 0 Tellurite resistance protein TerB LETM1 PF07766.13 KOO25383.1 - 0.065 12.6 0.8 0.16 11.3 0.6 1.9 1 1 0 1 1 1 0 LETM1-like protein Peptidase_M24 PF00557.24 KOO25383.1 - 0.089 12.5 0.2 1.8 8.2 0.0 2.4 2 1 1 3 3 3 0 Metallopeptidase family M24 DUF3911 PF13050.6 KOO25383.1 - 0.11 12.6 1.5 0.4 10.8 0.5 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3911) Acetyltransf_11 PF13720.6 KOO25383.1 - 0.15 12.5 0.4 1.2 9.7 0.1 2.4 1 1 1 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 PMBR PF09373.10 KOO25383.1 - 0.16 12.2 0.2 23 5.4 0.0 4.2 6 0 0 6 6 6 0 Pseudomurein-binding repeat YolD PF08863.10 KOO25383.1 - 0.19 11.8 2.4 6.9 6.8 0.1 2.7 3 1 0 3 3 3 0 YolD-like protein SapB_1 PF05184.15 KOO25383.1 - 1.2 9.3 6.8 3.2 7.8 0.2 2.7 3 0 0 3 3 2 0 Saposin-like type B, region 1 UDPGP PF01704.18 KOO25384.1 - 5.8e-05 21.9 0.0 6.5e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Phage_GP20 PF06810.11 KOO25384.1 - 0.0012 18.7 3.7 0.0017 18.1 3.7 1.2 1 0 0 1 1 1 1 Phage minor structural protein GP20 Ribosomal_L29 PF00831.23 KOO25384.1 - 0.061 13.3 10.7 0.45 10.5 3.7 3.0 1 1 1 2 2 2 0 Ribosomal L29 protein HGTP_anticodon PF03129.20 KOO25384.1 - 0.11 12.6 0.3 22 5.3 0.0 3.0 3 1 0 3 3 3 0 Anticodon binding domain FlxA PF14282.6 KOO25384.1 - 0.13 12.2 7.5 0.23 11.5 7.5 1.4 1 0 0 1 1 1 0 FlxA-like protein Laminin_II PF06009.12 KOO25384.1 - 0.14 12.2 8.5 0.23 11.5 8.5 1.3 1 0 0 1 1 1 0 Laminin Domain II FapA PF03961.13 KOO25384.1 - 0.45 9.1 5.2 0.2 10.2 0.4 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A YlqD PF11068.8 KOO25384.1 - 0.67 10.3 7.4 1.4 9.3 7.4 1.6 1 0 0 1 1 1 0 YlqD protein Spc7 PF08317.11 KOO25384.1 - 0.86 8.4 9.6 1.2 7.9 9.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FAM167 PF11652.8 KOO25384.1 - 1.5 9.3 4.2 2.6 8.6 2.9 2.0 1 1 1 2 2 2 0 FAM167 DUF2730 PF10805.8 KOO25384.1 - 1.9 8.6 5.7 32 4.7 5.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) NPV_P10 PF05531.12 KOO25384.1 - 3.8 8.0 6.4 20 5.7 6.2 2.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Uso1_p115_C PF04871.13 KOO25384.1 - 4.1 7.8 14.0 0.75 10.2 10.5 1.6 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Glyco_transf_22 PF03901.17 KOO25385.1 - 2.2e-50 172.1 7.7 2.8e-50 171.8 7.7 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family CS PF04969.16 KOO25385.1 - 8.4e-05 23.5 0.0 0.00013 22.9 0.0 1.3 1 0 0 1 1 1 1 CS domain NDUF_B12 PF08122.12 KOO25385.1 - 0.16 12.0 0.3 0.8 9.8 0.0 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family Aminotran_1_2 PF00155.21 KOO25386.1 - 4.4e-62 210.4 0.0 5.2e-62 210.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KOO25386.1 - 3.4e-06 26.3 0.0 4.9e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOO25386.1 - 8.2e-05 22.1 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 KOO25386.1 - 0.0017 17.0 0.0 0.0026 16.3 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 KOO25386.1 - 0.0093 15.3 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase BING4CT PF08149.11 KOO25386.1 - 0.044 13.6 0.1 0.21 11.4 0.0 2.1 2 0 0 2 2 2 0 BING4CT (NUC141) domain PDZ_6 PF17820.1 KOO25387.1 - 0.00019 21.2 0.1 0.00031 20.5 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO25387.1 - 0.00046 20.5 0.0 0.00068 19.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO25387.1 - 0.00076 19.8 0.0 0.0024 18.2 0.0 1.7 1 1 1 2 2 2 1 PDZ domain FAT PF02259.23 KOO25388.1 - 7.2e-77 258.9 0.5 7.2e-77 258.9 0.5 2.7 2 1 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 KOO25388.1 - 2.6e-71 240.4 0.1 4e-71 239.7 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 KOO25388.1 - 5.8e-40 135.7 5.7 2.3e-39 133.8 0.6 3.2 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain DUF3385 PF11865.8 KOO25388.1 - 6.8e-31 107.3 0.0 2.3e-26 92.6 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF3385) FATC PF02260.20 KOO25388.1 - 4.2e-12 45.7 2.2 5.7e-12 45.2 0.6 2.1 2 0 0 2 2 2 1 FATC domain HEAT_2 PF13646.6 KOO25388.1 - 4e-06 27.1 16.8 0.023 15.1 0.1 5.6 5 1 0 5 5 5 2 HEAT repeats HEAT PF02985.22 KOO25388.1 - 2.2e-05 24.3 20.9 0.22 11.9 0.1 8.9 10 0 0 10 10 10 3 HEAT repeat Tti2 PF10521.9 KOO25388.1 - 0.00012 21.8 0.9 0.026 14.1 0.0 3.7 2 1 2 4 4 4 1 Tti2 family MMS19_C PF12460.8 KOO25388.1 - 0.021 13.9 2.8 0.39 9.8 0.5 3.2 3 0 0 3 3 3 0 RNAPII transcription regulator C-terminal TPR_19 PF14559.6 KOO25388.1 - 2.2 8.9 7.3 2.6 8.6 0.0 4.6 6 0 0 6 6 3 0 Tetratricopeptide repeat HEAT_EZ PF13513.6 KOO25388.1 - 5 7.7 31.5 0.042 14.4 1.4 7.2 5 2 3 8 8 7 0 HEAT-like repeat TAFII55_N PF04658.13 KOO25389.1 - 1.8e-15 57.0 0.0 2.2e-14 53.5 0.0 2.1 1 1 0 1 1 1 1 TAFII55 protein conserved region Ribosomal_L28e PF01778.17 KOO25390.1 - 3.7e-27 95.4 0.1 4.5e-27 95.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family RNase_H PF00075.24 KOO25391.1 - 7.9e-33 113.7 0.0 1.2e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 KOO25391.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.8 1 1 0 1 1 1 0 Reverse transcriptase-like Alpha-amylase PF00128.24 KOO25392.1 - 1.1e-08 35.1 0.0 1.8e-06 27.7 0.0 2.1 2 0 0 2 2 2 2 Alpha amylase, catalytic domain KOG2701 PF09762.9 KOO25393.1 - 2.6e-53 180.9 0.0 2.6e-53 180.9 0.0 3.8 2 1 1 3 3 3 1 Coiled-coil domain-containing protein (DUF2037) Muted PF14942.6 KOO25393.1 - 0.0024 18.2 6.3 0.0024 18.2 6.3 3.9 1 1 2 4 4 4 1 Organelle biogenesis, Muted-like protein Baculo_PEP_C PF04513.12 KOO25393.1 - 0.26 11.3 6.2 4.9 7.2 0.8 3.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PMC2NT PF08066.12 KOO25393.1 - 0.73 10.6 6.9 0.57 10.9 0.3 3.5 3 0 0 3 3 3 0 PMC2NT (NUC016) domain DUF4208 PF13907.6 KOO25393.1 - 2.6 8.5 8.3 10 6.6 2.0 3.7 4 1 0 4 4 4 0 Domain of unknown function (DUF4208) RRM_1 PF00076.22 KOO25395.1 - 2.9e-10 39.8 0.0 4.1e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CENP-B_dimeris PF09026.10 KOO25395.1 - 0.64 10.4 5.9 1.9 8.9 3.6 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 KOO25395.1 - 5.6 7.4 7.3 0.89 10.0 1.8 2.4 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PBP_like_2 PF12849.7 KOO25396.1 - 4.2e-47 161.2 0.2 7e-47 160.4 0.2 1.3 1 0 0 1 1 1 1 PBP superfamily domain TFIIB PF00382.19 KOO25396.1 - 0.05 13.6 0.0 0.2 11.8 0.0 2.0 1 0 0 1 1 1 0 Transcription factor TFIIB repeat His_Phos_1 PF00300.22 KOO25398.1 - 1.3e-12 47.8 0.0 5.8e-11 42.4 0.0 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RVT_3 PF13456.6 KOO25398.1 - 3.7e-09 36.5 0.0 5.2e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase-like HlyIII PF03006.20 KOO25400.1 - 3.7e-11 43.2 14.7 5.1e-11 42.7 14.7 1.2 1 0 0 1 1 1 1 Haemolysin-III related PDR_assoc PF08370.11 KOO25400.1 - 0.075 12.8 0.5 0.075 12.8 0.5 2.1 3 0 0 3 3 3 0 Plant PDR ABC transporter associated UPF0182 PF03699.13 KOO25400.1 - 2.4 6.2 6.5 3.3 5.7 6.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Gly_transf_sug PF04488.15 KOO25401.1 - 9.2e-09 35.8 0.0 1.8e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 KOO25401.1 - 6.1e-05 22.5 1.1 0.0047 16.3 0.1 2.1 2 0 0 2 2 2 2 TcdA/TcdB catalytic glycosyltransferase domain EF-hand_1 PF00036.32 KOO25404.1 - 1.4e-26 90.0 13.2 9.3e-09 34.2 0.4 4.1 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 KOO25404.1 - 1.5e-25 89.4 3.6 2.7e-16 59.8 0.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO25404.1 - 7.7e-23 78.4 8.0 2.7e-08 33.1 0.2 4.0 2 1 1 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KOO25404.1 - 3.5e-21 73.7 8.8 3.4e-07 29.4 0.2 3.6 3 1 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO25404.1 - 7.7e-18 64.1 12.3 9.1e-08 31.8 0.0 4.3 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_11 PF08976.11 KOO25404.1 - 0.00013 22.8 0.0 0.017 16.0 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO25404.1 - 0.00047 20.4 0.1 0.29 11.5 0.0 2.4 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO25404.1 - 0.0072 16.3 0.7 3.1 7.7 0.1 2.7 2 1 1 3 3 3 2 Caleosin related protein p25-alpha PF05517.12 KOO25404.1 - 0.011 15.9 0.2 1 9.5 0.1 2.1 2 0 0 2 2 2 0 p25-alpha EF-hand_4 PF12763.7 KOO25404.1 - 0.074 13.0 1.4 1.1 9.3 0.1 2.7 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 KOO25404.1 - 0.082 13.3 0.2 0.16 12.3 0.1 1.7 1 1 0 1 1 1 0 EF-hand domain DUF5580 PF17743.1 KOO25404.1 - 0.15 10.6 0.0 2.6 6.5 0.0 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5580) DnaJ PF00226.31 KOO25405.1 - 2.9e-06 27.3 0.0 6.2e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Zf_RING PF16744.5 KOO25405.1 - 0.052 13.7 0.2 0.14 12.3 0.1 1.7 2 0 0 2 2 2 0 KIAA1045 RING finger NRDD PF13597.6 KOO25405.1 - 0.19 10.5 0.4 0.25 10.1 0.4 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase CcdA PF07362.12 KOO25405.1 - 0.39 11.2 3.4 0.87 10.1 3.4 1.5 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA eIF-5_eIF-2B PF01873.17 KOO25406.1 - 9.4e-37 125.5 0.0 1.5e-36 124.8 0.0 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Lar_restr_allev PF14354.6 KOO25406.1 - 0.013 15.9 0.1 0.05 14.0 0.1 2.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-ribbon_3 PF13248.6 KOO25406.1 - 0.082 12.3 1.7 3.8 7.1 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-HYPF PF07503.12 KOO25406.1 - 0.11 12.3 0.8 8.7 6.2 0.1 2.6 2 0 0 2 2 2 0 HypF finger DUF35_N PF12172.8 KOO25406.1 - 0.25 11.3 1.4 0.45 10.4 0.1 2.1 1 1 1 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Arc_trans_TRASH PF08394.10 KOO25406.1 - 5.4 7.4 5.7 2.5 8.5 0.3 2.4 1 1 1 2 2 2 0 Archaeal TRASH domain Totivirus_coat PF05518.11 KOO25406.1 - 5.5 4.9 5.1 7.3 4.5 5.1 1.1 1 0 0 1 1 1 0 Totivirus coat protein Arm PF00514.23 KOO25408.1 - 2e-225 723.1 190.2 7.7e-09 35.3 0.8 64.7 67 0 0 67 67 66 44 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO25408.1 - 1.3e-24 86.1 35.2 0.0014 18.6 0.4 17.6 18 3 2 21 21 19 9 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_N PF03224.14 KOO25408.1 - 3.2e-21 75.9 4.9 0.001 18.5 0.0 14.0 6 4 5 12 12 12 3 V-ATPase subunit H Arm_2 PF04826.13 KOO25408.1 - 3.4e-18 66.0 30.1 0.27 10.6 0.1 17.4 11 5 7 18 18 18 6 Armadillo-like RICTOR_N PF14664.6 KOO25408.1 - 2e-13 50.1 1.5 5.3 5.9 0.0 11.7 9 4 0 11 11 11 1 Rapamycin-insensitive companion of mTOR, N-term Cnd1 PF12717.7 KOO25408.1 - 7.4e-12 45.6 19.2 1.9 8.5 0.0 13.7 14 2 1 15 15 15 2 non-SMC mitotic condensation complex subunit 1 DUF5578 PF17741.1 KOO25408.1 - 7.2e-11 42.0 48.0 0.0037 16.7 0.0 12.7 12 3 3 15 15 15 6 Family of unknown function (DUF5578) Adaptin_N PF01602.20 KOO25408.1 - 4.8e-08 32.0 24.0 0.23 10.0 0.8 9.6 10 2 1 11 11 11 4 Adaptin N terminal region EF-hand_1 PF00036.32 KOO25408.1 - 5e-08 31.9 4.2 0.00056 19.3 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO25408.1 - 7.1e-08 32.2 0.2 5.2e-07 29.4 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain pair HEAT_2 PF13646.6 KOO25408.1 - 7.5e-08 32.7 178.2 0.026 14.9 1.2 25.6 17 8 8 26 26 25 9 HEAT repeats EF-hand_6 PF13405.6 KOO25408.1 - 1.6e-07 30.7 3.4 0.00061 19.5 0.1 3.2 3 0 0 3 3 2 2 EF-hand domain V-ATPase_H_C PF11698.8 KOO25408.1 - 9.8e-07 28.9 15.1 0.67 10.1 0.0 10.0 13 2 1 15 15 13 3 V-ATPase subunit H DUF4704 PF15787.5 KOO25408.1 - 1.3e-06 27.8 1.6 1.1 8.4 0.2 6.5 7 2 1 8 8 8 2 Domain of unknown function (DUF4704) EF-hand_7 PF13499.6 KOO25408.1 - 1e-05 25.9 3.1 5.7e-05 23.5 2.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair HEAT PF02985.22 KOO25408.1 - 0.00082 19.4 59.3 0.75 10.2 0.1 20.8 22 0 0 22 22 18 1 HEAT repeat EF-hand_5 PF13202.6 KOO25408.1 - 0.0019 17.6 7.9 0.029 13.9 0.3 3.6 4 0 0 4 4 4 2 EF hand CLASP_N PF12348.8 KOO25408.1 - 0.0098 15.5 8.2 4.2 6.9 0.0 6.5 6 0 0 6 6 6 1 CLASP N terminal MtrA PF04208.14 KOO25408.1 - 0.035 13.7 1.5 34 4.0 0.1 5.9 5 1 0 6 6 6 0 Tetrahydromethanopterin S-methyltransferase, subunit A KAP PF05804.12 KOO25408.1 - 0.051 11.7 0.0 29 2.6 0.0 4.7 5 1 0 5 5 5 0 Kinesin-associated protein (KAP) RdRP PF05183.12 KOO25409.1 - 4.8e-60 203.8 0.0 7.9e-60 203.1 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase DEAD PF00270.29 KOO25409.1 - 3.4e-16 59.5 0.5 6.6e-15 55.3 0.3 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO25409.1 - 2e-12 47.5 0.0 6.8e-12 45.7 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO25409.1 - 7.6e-10 39.1 0.1 2.4e-09 37.4 0.1 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MBD PF01429.19 KOO25409.1 - 1.1e-07 31.5 0.0 2.7e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain Chromo PF00385.24 KOO25409.1 - 3.5e-06 26.8 0.1 7.5e-06 25.8 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RecQ_Zn_bind PF16124.5 KOO25409.1 - 6.4 7.6 10.8 0.39 11.5 3.6 2.9 2 0 0 2 2 2 0 RecQ zinc-binding V_ATPase_I PF01496.19 KOO25409.1 - 9 4.1 8.9 16 3.2 8.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pkinase PF00069.25 KOO25410.1 - 5.5e-55 186.6 0.0 7.7e-55 186.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25410.1 - 2.1e-38 132.1 0.0 2.8e-38 131.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO25410.1 - 7.5e-05 21.7 0.0 0.00037 19.4 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOO25410.1 - 0.01 15.2 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Mucin-like PF16058.5 KOO25410.1 - 1.4 9.1 7.1 0.25 11.4 3.1 1.7 2 0 0 2 2 2 0 Mucin-like Pkinase PF00069.25 KOO25412.1 - 3.3e-46 157.8 0.0 4.8e-46 157.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25412.1 - 2.5e-14 53.2 0.0 4e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase ACT PF01842.25 KOO25412.1 - 9.5e-07 28.5 0.3 0.00022 20.9 0.1 2.5 2 0 0 2 2 2 2 ACT domain Kinase-like PF14531.6 KOO25412.1 - 0.0055 16.1 0.0 1.2 8.4 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KOO25412.1 - 0.0094 14.8 0.0 0.02 13.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase ACT_4 PF13291.6 KOO25412.1 - 0.0095 16.5 0.3 1.6 9.4 0.0 3.2 3 0 0 3 3 3 1 ACT domain ACT_6 PF13740.6 KOO25412.1 - 0.026 14.5 0.1 0.63 10.1 0.0 3.0 2 0 0 2 2 2 0 ACT domain APH PF01636.23 KOO25412.1 - 0.29 11.0 14.1 40 4.0 0.1 4.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family Aldedh PF00171.22 KOO25413.1 - 3e-05 22.7 0.1 0.0082 14.7 0.0 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family AA_kinase PF00696.28 KOO25414.1 - 6.1e-29 101.3 0.4 6.9e-29 101.1 0.4 1.0 1 0 0 1 1 1 1 Amino acid kinase family Abhydrolase_6 PF12697.7 KOO25415.1 - 5.2e-05 23.9 2.0 6.9e-05 23.6 2.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO25415.1 - 0.00032 20.0 0.0 0.004 16.4 0.1 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_8 PF06259.12 KOO25415.1 - 0.0064 16.1 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase DLH PF01738.18 KOO25415.1 - 0.038 13.6 0.0 0.073 12.6 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Acyl-CoA_dh_M PF02770.19 KOO25416.1 - 8.9e-22 77.1 0.0 6.2e-21 74.4 0.0 2.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 KOO25416.1 - 1e-20 74.5 1.5 2.6e-19 69.9 0.6 3.0 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOO25416.1 - 1.1e-18 67.9 0.0 2.5e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_C PF12806.7 KOO25416.1 - 9.2e-16 58.1 0.3 2.8e-15 56.6 0.3 1.9 1 0 0 1 1 1 1 Acetyl-CoA dehydrogenase C-terminal like AcylCoA_DH_N PF12418.8 KOO25416.1 - 1.2e-05 25.2 0.1 2.7e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase N terminal Acyl-CoA_dh_2 PF08028.11 KOO25416.1 - 0.00033 20.9 0.8 0.0027 18.0 0.0 2.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Neur_chan_LBD PF02931.23 KOO25417.1 - 0.0014 18.1 2.0 0.0024 17.4 1.0 2.1 1 1 1 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain adh_short_C2 PF13561.6 KOO25418.1 - 1.5e-43 149.0 4.9 1.5e-32 113.1 2.5 2.8 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO25418.1 - 4.2e-34 117.7 0.4 6.3e-26 91.0 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 KOO25418.1 - 0.00021 21.2 0.1 0.00047 20.1 0.1 1.5 1 0 0 1 1 1 1 KR domain AdoHcyase_NAD PF00670.21 KOO25418.1 - 0.056 13.5 0.7 0.1 12.6 0.6 1.5 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain UVR PF02151.19 KOO25419.1 - 2.7e-08 33.3 15.2 0.00033 20.3 1.0 4.0 3 2 1 4 4 4 2 UvrB/uvrC motif Rubredoxin_C PF18267.1 KOO25419.1 - 3.8e-07 29.9 1.5 0.25 11.3 0.0 3.2 3 0 0 3 3 3 2 Rubredoxin NAD+ reductase C-terminal domain RVT_N PF13655.6 KOO25419.1 - 0.0044 17.2 1.3 0.19 12.0 0.1 2.5 1 1 1 2 2 2 1 N-terminal domain of reverse transcriptase DUF5503 PF17607.2 KOO25419.1 - 0.0056 17.0 0.0 0.013 15.8 0.0 1.7 1 1 0 2 2 2 1 Family of unknown function (DUF5503) T3SS_needle_E PF08988.10 KOO25419.1 - 0.21 11.7 6.0 1.2 9.3 0.9 2.9 1 1 2 3 3 3 0 Type III secretion system, cytoplasmic E component of needle ABC_tran_CTD PF16326.5 KOO25419.1 - 0.98 9.7 15.9 11 6.4 1.3 3.4 2 1 1 3 3 3 0 ABC transporter C-terminal domain Lipoprotein_11 PF03260.13 KOO25419.1 - 1.2 8.5 3.8 5.1 6.4 0.4 2.6 1 1 2 3 3 3 0 Lepidopteran low molecular weight (30 kD) lipoprotein DUF2344 PF10105.9 KOO25419.1 - 1.7 8.4 5.0 3.6 7.4 5.0 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) NOZZLE PF08744.10 KOO25419.1 - 1.8 8.0 5.0 4.3 6.7 0.1 2.8 1 1 1 3 3 3 0 Plant transcription factor NOZZLE FKBP_C PF00254.28 KOO25420.1 - 5.9e-18 65.0 0.0 8.8e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.6 KOO25420.1 - 1e-06 29.1 1.3 1.9e-06 28.2 1.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO25420.1 - 1.3e-06 27.6 2.0 0.00057 19.2 0.5 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO25420.1 - 5.1e-06 25.7 1.4 0.00036 19.9 0.2 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO25420.1 - 2.9e-05 23.8 3.8 8.2e-05 22.4 1.2 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO25420.1 - 0.00014 21.5 1.2 0.12 12.3 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain RVT_2 PF07727.14 KOO25421.1 - 4.2e-29 101.9 0.0 7.4e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KOO25421.1 - 8.8e-13 48.5 0.0 2.2e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain HetR_C PF18460.1 KOO25423.1 - 0.024 14.5 0.2 2.7 8.0 0.0 2.9 3 0 0 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain Flg_hook PF02120.16 KOO25423.1 - 0.28 11.1 0.9 30 4.6 0.0 3.4 4 0 0 4 4 4 0 Flagellar hook-length control protein FliK PEX11 PF05648.14 KOO25424.1 - 8e-10 38.6 1.8 1.6e-09 37.6 1.8 1.5 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Chitin_synth_2 PF03142.15 KOO25424.1 - 0.061 11.9 0.1 0.076 11.6 0.1 1.1 1 0 0 1 1 1 0 Chitin synthase Cons_hypoth698 PF03601.14 KOO25424.1 - 6 5.6 9.2 1 8.2 4.5 1.9 2 1 1 3 3 3 0 Conserved hypothetical protein 698 Snf7 PF03357.21 KOO25425.1 - 3.3e-13 49.6 8.9 3.3e-13 49.6 8.9 1.6 1 1 1 2 2 2 1 Snf7 HAP PF03866.13 KOO25425.1 - 0.077 13.0 0.8 0.11 12.5 0.8 1.3 1 0 0 1 1 1 0 Hydrophobic abundant protein (HAP) Ribosomal_L37 PF08561.10 KOO25425.1 - 0.44 11.1 3.3 0.69 10.4 3.3 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 Glyco_hydro_2_C PF02836.17 KOO25427.1 - 5.8e-22 78.2 0.0 9e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 KOO25427.1 - 0.00026 20.9 0.0 0.00064 19.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 KOO25427.1 - 0.048 14.3 0.0 0.1 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 2 Paramyxo_PNT PF14320.6 KOO25427.1 - 0.12 11.5 0.1 0.23 10.6 0.1 1.4 1 0 0 1 1 1 0 Phosphoprotein P region PNT disordered Cupin_8 PF13621.6 KOO25428.1 - 1.3e-17 64.4 0.0 1.8e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 KOO25428.1 - 3.4e-05 24.2 0.0 6.6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 KOO25428.1 - 0.029 13.9 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein Cupin_1 PF00190.22 KOO25428.1 - 0.08 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Cupin ADK PF00406.22 KOO25429.1 - 8.4e-53 178.5 0.0 9.8e-53 178.3 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO25429.1 - 8.4e-27 94.2 0.1 1.8e-26 93.2 0.0 1.5 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 KOO25429.1 - 2.8e-15 56.0 0.0 6e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 KOO25429.1 - 1.8e-06 28.4 0.5 0.0055 17.0 0.1 3.0 2 1 1 3 3 3 2 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 KOO25429.1 - 0.00013 22.2 0.0 0.00023 21.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO25429.1 - 0.0015 19.0 0.0 0.0032 18.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 KOO25429.1 - 0.0097 15.7 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase AAA PF00004.29 KOO25429.1 - 0.031 14.7 0.1 0.057 13.8 0.1 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KOO25429.1 - 0.15 11.4 0.2 0.22 10.9 0.2 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC1 PF03109.16 KOO25430.1 - 3.3e-26 91.8 0.0 7.2e-26 90.7 0.0 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 KOO25430.1 - 2.6e-07 30.4 0.0 5.8e-06 26.0 0.0 2.4 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 KOO25430.1 - 1.2e-05 25.3 0.0 0.00028 20.9 0.0 2.4 1 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO25430.1 - 0.0013 18.1 0.0 0.0048 16.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Asparaginase_II PF06089.12 KOO25430.1 - 0.023 13.7 0.1 0.041 12.9 0.1 1.3 1 0 0 1 1 1 0 L-asparaginase II POTRA_2 PF08479.11 KOO25430.1 - 0.027 14.3 0.0 0.52 10.2 0.0 2.3 2 0 0 2 2 2 0 POTRA domain, ShlB-type PX PF00787.24 KOO25432.1 - 3.6e-12 46.3 0.0 6e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 PX domain Cyclin_N PF00134.23 KOO25432.1 - 0.0021 17.8 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pkinase PF00069.25 KOO25433.1 - 2.6e-63 213.9 0.0 3.3e-63 213.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25433.1 - 3.2e-50 170.8 0.0 4.3e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO25433.1 - 6.2e-05 22.0 0.0 9.6e-05 21.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO25433.1 - 8.9e-05 21.9 0.0 0.0052 16.1 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOO25433.1 - 0.00058 18.9 0.0 0.24 10.3 0.0 2.2 1 1 1 2 2 2 2 Haspin like kinase domain APH PF01636.23 KOO25433.1 - 0.002 18.1 0.4 0.049 13.5 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family DUF1192 PF06698.11 KOO25433.1 - 0.18 11.9 1.4 0.45 10.6 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Nic96 PF04097.14 KOO25434.1 - 1.1e-26 93.5 0.0 1.3e-24 86.6 0.1 2.1 2 0 0 2 2 2 2 Nup93/Nic96 RNaseH_C PF09293.10 KOO25434.1 - 0.0017 18.7 0.0 0.0036 17.6 0.0 1.5 1 0 0 1 1 1 1 T4 RNase H, C terminal Ubie_methyltran PF01209.18 KOO25435.1 - 0.052 12.9 0.0 0.052 12.9 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family zf-RING_UBOX PF13445.6 KOO25436.1 - 1.2e-10 41.3 6.0 4.1e-10 39.5 5.9 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOO25436.1 - 1.2e-10 41.1 5.8 2e-10 40.4 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO25436.1 - 1.2e-10 41.5 8.4 2e-10 40.8 8.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KOO25436.1 - 5.4e-09 35.9 8.4 1e-08 35.0 8.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOO25436.1 - 2.8e-08 33.5 8.3 5.2e-08 32.6 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO25436.1 - 4.9e-08 32.7 9.7 1e-07 31.7 9.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO25436.1 - 1.7e-07 31.0 10.0 2.2e-07 30.6 3.3 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 U-box PF04564.15 KOO25436.1 - 2.1e-05 24.6 0.0 5.6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-C3HC4_4 PF15227.6 KOO25436.1 - 4.3e-05 23.6 8.3 8.6e-05 22.6 8.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 KOO25436.1 - 0.00025 20.8 6.5 0.00045 20.0 6.5 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KOO25436.1 - 0.0013 19.0 10.0 0.0095 16.2 10.1 2.3 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOO25436.1 - 0.003 17.6 3.0 0.0058 16.7 3.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 KOO25436.1 - 0.013 15.2 2.5 0.028 14.2 2.5 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-Di19 PF05605.12 KOO25436.1 - 0.017 15.4 3.7 0.87 9.9 2.0 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Pellino PF04710.14 KOO25436.1 - 0.064 11.9 0.4 0.11 11.1 0.4 1.4 1 0 0 1 1 1 0 Pellino YdjO PF14169.6 KOO25436.1 - 0.11 12.3 6.2 0.33 10.7 1.9 2.3 1 1 1 2 2 2 0 Cold-inducible protein YdjO Spc7 PF08317.11 KOO25436.1 - 0.13 11.1 8.6 0.2 10.5 8.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein IBR PF01485.21 KOO25436.1 - 0.42 10.9 4.6 0.79 10.0 2.8 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain FANCL_C PF11793.8 KOO25436.1 - 0.58 10.4 5.5 5.4 7.3 5.5 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_10 PF16685.5 KOO25436.1 - 0.64 10.2 6.3 0.22 11.7 3.4 1.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 zinc-ribbons_6 PF07191.12 KOO25436.1 - 0.77 9.8 6.1 1.7 8.7 6.1 1.5 1 0 0 1 1 1 0 zinc-ribbons Fez1 PF06818.15 KOO25436.1 - 0.78 10.2 12.4 0.19 12.2 9.2 1.5 2 0 0 2 2 2 0 Fez1 zf-Nse PF11789.8 KOO25436.1 - 1.4 8.7 6.4 3.3 7.6 6.4 1.6 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 KOO25436.1 - 1.6 8.7 4.2 12 5.9 4.2 2.1 1 1 1 2 2 2 0 zf-RING of BARD1-type protein TFIIA PF03153.13 KOO25436.1 - 2.1 8.2 12.0 2.8 7.8 12.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DZR PF12773.7 KOO25436.1 - 3.9 7.6 7.8 56 3.9 8.0 2.2 1 1 0 1 1 1 0 Double zinc ribbon Ras PF00071.22 KOO25438.1 - 1e-33 116.2 0.0 1.9e-33 115.4 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO25438.1 - 7.6e-22 77.8 0.0 1.3e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO25438.1 - 2.2e-05 24.0 0.0 3.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.6 KOO25438.1 - 0.00019 21.9 1.8 0.00041 20.8 0.0 2.4 3 0 0 3 3 3 1 AAA ATPase domain MMR_HSR1 PF01926.23 KOO25438.1 - 0.0081 16.2 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 KOO25438.1 - 0.014 15.4 0.0 0.099 12.6 0.1 2.3 3 0 0 3 3 3 0 NACHT domain AAA_22 PF13401.6 KOO25438.1 - 0.065 13.5 0.0 0.15 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 KOO25438.1 - 0.19 11.1 0.0 0.38 10.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein TBCC_N PF16752.5 KOO25439.1 - 0.00044 20.7 1.8 0.0016 18.9 1.8 1.8 1 1 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain ABC_tran_CTD PF16326.5 KOO25439.1 - 0.0025 18.0 1.5 0.0025 18.0 1.5 1.6 2 0 0 2 2 2 1 ABC transporter C-terminal domain FlxA PF14282.6 KOO25439.1 - 0.013 15.4 2.1 0.022 14.7 1.0 1.8 1 1 0 1 1 1 0 FlxA-like protein DUF3138 PF11336.8 KOO25439.1 - 0.031 12.9 0.2 0.034 12.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF4164 PF13747.6 KOO25439.1 - 0.048 13.9 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) DUF4407 PF14362.6 KOO25439.1 - 0.058 12.8 0.4 0.067 12.5 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 KOO25439.1 - 0.064 13.0 0.7 1.3 8.9 0.1 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF5082 PF16888.5 KOO25439.1 - 0.11 12.8 0.3 0.25 11.6 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) SlyX PF04102.12 KOO25439.1 - 0.18 12.5 4.4 0.5 11.0 1.4 2.3 1 1 1 2 2 2 0 SlyX Csm1_N PF18504.1 KOO25439.1 - 0.29 11.5 1.4 2.1 8.7 0.3 2.2 1 1 0 2 2 2 0 Csm1 N-terminal domain DUF4124 PF13511.6 KOO25440.1 - 0.038 14.3 0.4 1.4 9.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4124) TPR_12 PF13424.6 KOO25441.1 - 1.6e-28 98.8 49.2 1.8e-10 41.0 0.3 6.7 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 KOO25441.1 - 4.1e-19 67.8 34.4 1.6e-06 27.7 0.4 9.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOO25441.1 - 0.087 12.5 0.2 3.9 7.3 0.1 3.3 3 0 0 3 3 3 0 TPR repeat TPR_7 PF13176.6 KOO25441.1 - 0.9 9.7 17.6 1.8 8.8 0.1 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO25441.1 - 1.1 9.5 0.0 1.1 9.5 0.0 7.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25441.1 - 2.1 8.3 12.8 28 4.7 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 KOO25442.1 - 2e-42 145.3 0.0 1.3e-41 142.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO25442.1 - 1.2e-38 133.0 0.0 2.5e-38 132.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 KOO25442.1 - 0.031 13.2 0.3 0.049 12.6 0.3 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 KOO25442.1 - 0.037 13.4 0.3 0.068 12.5 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO25442.1 - 0.042 13.8 0.0 0.087 12.7 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO25442.1 - 0.19 11.0 0.0 0.4 9.9 0.0 1.5 1 1 0 1 1 1 0 Kinase-like DBD_Tnp_Mut PF03108.15 KOO25443.1 - 0.3 11.1 0.5 21 5.2 0.0 2.2 2 0 0 2 2 2 0 MuDR family transposase VPS13 PF16908.5 KOO25445.1 - 1.5e-13 51.1 0.0 2.3e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 KOO25445.1 - 2.5e-06 27.6 0.1 4.7e-05 23.5 0.0 2.8 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 PaaX PF07848.12 KOO25445.1 - 0.016 15.4 0.0 0.059 13.6 0.0 1.9 1 0 0 1 1 1 0 PaaX-like protein ELM2 PF01448.24 KOO25447.1 - 0.0021 18.8 0.1 0.0063 17.2 0.1 1.9 1 0 0 1 1 1 1 ELM2 domain Abhydrolase_1 PF00561.20 KOO25448.1 - 7e-07 29.1 0.7 3e-06 27.1 0.7 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO25448.1 - 0.0068 15.7 0.4 0.02 14.2 0.3 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Sulfate_transp PF00916.20 KOO25449.1 - 7e-33 113.9 29.5 1.9e-19 69.7 12.6 3.1 2 1 1 3 3 3 3 Sulfate permease family Glucosamine_iso PF01182.20 KOO25450.1 - 1.9e-30 106.5 0.0 3.5e-30 105.6 0.0 1.4 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase AICARFT_IMPCHas PF01808.18 KOO25451.1 - 1.5e-77 260.9 0.0 2e-77 260.6 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 KOO25451.1 - 8.6e-26 90.0 0.0 1.5e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 MGS-like domain DUF5320 PF17253.2 KOO25452.1 - 1 10.5 0.0 1 10.5 0.0 10.2 10 2 1 11 11 11 0 Family of unknown function (DUF5320) Exo_endo_phos PF03372.23 KOO25453.1 - 0.0089 15.6 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PHM7_cyt PF14703.6 KOO25454.1 - 1.6e-09 38.2 0.0 8.1e-09 36.0 0.0 2.0 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter ATP-synt_8 PF00895.20 KOO25454.1 - 3.8 8.0 7.6 16 6.1 0.1 3.4 2 1 0 2 2 2 0 ATP synthase protein 8 Proteasome PF00227.26 KOO25455.1 - 7.7e-49 165.8 0.3 8.9e-49 165.6 0.3 1.0 1 0 0 1 1 1 1 Proteasome subunit NHL PF01436.21 KOO25456.1 - 2.7e-41 137.6 17.2 2.9e-08 33.4 0.1 7.0 6 1 0 6 6 6 6 NHL repeat DUF5128 PF17170.4 KOO25456.1 - 9.8e-19 67.7 2.3 6.6e-06 25.5 0.1 5.1 1 1 5 6 6 6 5 6-bladed beta-propeller BACK PF07707.15 KOO25456.1 - 4.9e-16 58.7 0.2 7.4e-16 58.1 0.2 1.2 1 0 0 1 1 1 1 BTB And C-terminal Kelch SGL PF08450.12 KOO25456.1 - 2.9e-12 46.7 0.0 0.00078 19.1 0.0 3.5 1 1 2 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region TolB_like PF15869.5 KOO25456.1 - 4.6e-07 29.4 0.1 0.054 12.7 0.0 4.1 2 2 1 4 4 4 2 TolB-like 6-blade propeller-like DUF4934 PF16288.5 KOO25456.1 - 5e-07 29.6 0.0 0.051 13.5 0.0 4.0 2 1 2 4 4 4 2 Domain of unknown function (DUF4934) Arylesterase PF01731.20 KOO25456.1 - 4e-06 26.9 0.0 0.16 12.2 0.0 4.1 4 0 0 4 4 4 1 Arylesterase Phytase-like PF13449.6 KOO25456.1 - 6.7e-06 26.3 0.0 0.15 12.0 0.0 3.6 1 1 1 2 2 2 2 Esterase-like activity of phytase PQQ_3 PF13570.6 KOO25456.1 - 3.3e-05 24.2 1.1 1.7 9.2 0.0 5.1 5 0 0 5 5 5 1 PQQ-like domain Str_synth PF03088.16 KOO25456.1 - 0.00017 21.6 0.0 11 6.2 0.0 4.0 4 0 0 4 4 4 1 Strictosidine synthase DUF839 PF05787.13 KOO25456.1 - 0.00019 20.8 0.7 4.8 6.2 0.1 3.8 1 1 1 3 3 3 2 Bacterial protein of unknown function (DUF839) Lactonase PF10282.9 KOO25456.1 - 0.00034 20.0 0.0 0.016 14.5 0.0 2.9 1 1 2 4 4 4 3 Lactonase, 7-bladed beta-propeller ANAPC4_WD40 PF12894.7 KOO25456.1 - 0.0055 17.0 0.0 5.1 7.5 0.0 3.0 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KOO25456.1 - 0.015 14.9 0.0 0.21 11.2 0.0 2.4 2 1 0 2 2 2 0 PQQ-like domain Colipase-like PF15083.6 KOO25456.1 - 0.069 13.3 2.5 0.59 10.3 1.2 2.1 2 0 0 2 2 2 0 Colipase-like MoeA_C PF03454.15 KOO25456.1 - 0.13 12.4 0.7 1.7 8.9 0.0 3.1 3 1 1 4 4 4 0 MoeA C-terminal region (domain IV) Filamin PF00630.19 KOO25457.1 - 3.2e-85 281.7 0.0 3.8e-13 50.2 0.0 9.2 8 1 1 9 9 9 9 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO25457.1 - 1.1e-11 44.9 4.5 0.00035 20.8 0.0 8.5 7 3 3 10 10 10 2 Invasin, domain 3 Big_1 PF02369.16 KOO25457.1 - 0.00071 19.5 0.3 0.47 10.5 0.0 5.5 6 0 0 6 6 6 1 Bacterial Ig-like domain (group 1) YtkA PF13115.6 KOO25457.1 - 0.0013 19.3 0.0 68 4.2 0.0 4.8 4 0 0 4 4 4 0 YtkA-like Glyco_hydro2_C5 PF18565.1 KOO25457.1 - 0.018 14.9 0.0 18 5.2 0.0 4.1 4 0 0 4 4 4 0 Glycoside hydrolase family 2 C-terminal domain 5 ABC_tran PF00005.27 KOO25458.1 - 1.8e-08 35.0 0.0 3.9e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 KOO25458.1 - 7.5e-05 23.0 1.7 0.00099 19.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 KOO25458.1 - 0.0021 18.6 0.0 0.015 15.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 KOO25458.1 - 0.0053 16.6 0.1 0.008 16.0 0.1 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOO25458.1 - 0.0053 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KOO25458.1 - 0.011 15.9 0.0 0.03 14.4 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase MeaB PF03308.16 KOO25458.1 - 0.012 14.6 0.2 0.6 9.0 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 KOO25458.1 - 0.033 14.1 0.2 0.08 12.8 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 KOO25458.1 - 0.043 13.7 0.0 0.086 12.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Adeno_IVa2 PF02456.15 KOO25458.1 - 0.13 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_15 PF13175.6 KOO25458.1 - 0.27 10.9 0.0 0.42 10.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 KOO25459.1 - 1.7e-32 112.8 0.7 1.8e-20 73.8 0.0 3.2 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 KOO25459.1 - 6e-09 36.1 0.6 0.031 14.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO25459.1 - 1.5e-05 24.6 0.0 0.0011 18.4 0.0 2.9 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_tran_Xtn PF12848.7 KOO25459.1 - 0.0001 22.3 6.6 0.00024 21.1 6.6 1.6 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 KOO25459.1 - 0.0012 19.4 3.2 0.85 10.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOO25459.1 - 0.0049 17.3 0.7 0.069 13.5 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 KOO25459.1 - 0.022 14.5 0.1 0.051 13.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO25459.1 - 0.024 14.9 0.1 0.15 12.3 0.1 2.3 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO25459.1 - 0.05 13.5 0.0 0.092 12.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 KOO25459.1 - 0.07 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 KOO25459.1 - 0.085 13.1 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DLIC PF05783.11 KOO25459.1 - 0.11 11.3 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) RhoGEF67_u2 PF16614.5 KOO25459.1 - 0.15 12.2 0.3 0.25 11.4 0.3 1.3 1 0 0 1 1 1 0 Unstructured region two on RhoGEF 6 and 7 AAA_5 PF07728.14 KOO25459.1 - 0.16 12.0 0.5 1.8 8.6 0.1 2.7 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 KOO25459.1 - 0.38 10.7 2.4 0.26 11.2 0.2 1.8 2 0 0 2 2 2 0 RsgA GTPase Pkinase PF00069.25 KOO25461.1 - 9.7e-16 57.9 0.0 1.7e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25461.1 - 5.7e-08 32.4 0.0 5.5e-07 29.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO25461.1 - 0.07 13.0 0.4 6.4 6.6 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ank_2 PF12796.7 KOO25462.1 - 8.2e-61 202.6 24.6 8.5e-13 48.7 1.2 7.3 3 1 8 11 11 11 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO25462.1 - 1.5e-51 172.1 5.1 6e-08 33.1 0.0 11.1 5 3 6 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO25462.1 - 2.4e-31 107.4 13.3 0.00048 20.4 0.1 10.3 6 2 3 10 10 10 6 Ankyrin repeats (many copies) Ank PF00023.30 KOO25462.1 - 2.4e-29 100.4 13.8 0.057 13.9 0.0 13.3 13 1 0 13 13 13 7 Ankyrin repeat Ank_3 PF13606.6 KOO25462.1 - 3.3e-27 91.5 9.8 0.029 14.9 0.0 13.5 13 0 0 13 13 13 5 Ankyrin repeat PUB PF09409.10 KOO25462.1 - 1.9e-15 56.6 0.1 5.4e-15 55.1 0.1 1.7 1 0 0 1 1 1 1 PUB domain Pkinase PF00069.25 KOO25462.1 - 1.2e-06 28.1 0.0 2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25462.1 - 1.6e-06 27.6 0.0 3e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SAM_1 PF00536.30 KOO25462.1 - 7.8e-05 23.0 0.0 0.00018 21.8 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO25462.1 - 0.00016 21.7 0.0 0.00042 20.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_12 PF18129.1 KOO25462.1 - 0.19 11.8 0.1 0.45 10.6 0.1 1.6 1 0 0 1 1 1 0 Xrn1 SH3-like domain UIM PF02809.20 KOO25462.1 - 3.9 7.6 10.5 0.57 10.2 3.4 2.8 2 0 0 2 2 2 0 Ubiquitin interaction motif Coilin_N PF15862.5 KOO25462.1 - 5.1 6.9 9.0 15 5.4 9.0 1.7 1 0 0 1 1 1 0 Coilin N-terminus SH3BP5 PF05276.14 KOO25463.1 - 8.5e-12 45.4 12.0 1.2e-11 44.9 12.0 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DUF3086 PF11285.8 KOO25463.1 - 0.0074 15.4 5.3 0.012 14.7 5.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3086) Retrotrans_gag PF03732.17 KOO25463.1 - 1.3 9.3 5.5 0.88 9.9 1.6 2.4 2 1 1 3 3 3 0 Retrotransposon gag protein TMF_DNA_bd PF12329.8 KOO25463.1 - 1.8 8.6 14.1 0.13 12.3 5.8 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding V_ATPase_I PF01496.19 KOO25463.1 - 3 5.6 4.2 4.1 5.2 4.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 KOO25463.1 - 5.1 7.2 27.6 4.7 7.3 18.8 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein YL1_C PF08265.11 KOO25464.1 - 3.8e-05 23.4 0.1 5.5e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Voldacs PF03517.13 KOO25464.1 - 0.026 14.7 0.3 0.033 14.3 0.3 1.1 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling zf-HIT PF04438.16 KOO25464.1 - 0.075 12.9 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 HIT zinc finger HGTP_anticodon2 PF12745.7 KOO25464.1 - 0.085 12.4 4.4 0.11 12.0 4.4 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs CDC45 PF02724.14 KOO25464.1 - 0.37 9.0 7.1 0.37 9.0 7.1 1.0 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 KOO25464.1 - 0.63 10.5 6.9 1 9.8 6.9 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4611 PF15387.6 KOO25464.1 - 1.1 9.6 7.6 1.7 8.9 7.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) LRR_6 PF13516.6 KOO25465.1 - 6.9e-28 94.3 3.6 0.00015 21.5 0.0 6.2 6 0 0 6 6 6 6 Leucine Rich repeat LRR_4 PF12799.7 KOO25465.1 - 1.7e-09 37.8 0.0 0.042 14.3 0.0 4.1 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO25465.1 - 4.5e-06 26.3 4.2 0.077 12.8 0.5 4.6 3 2 0 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 KOO25465.1 - 4.6e-06 26.4 0.0 6.9 7.6 0.0 5.7 6 1 0 6 6 6 1 Leucine Rich Repeat HHH_5 PF14520.6 KOO25465.1 - 0.68 10.6 3.0 5.9 7.6 0.3 3.5 4 1 0 4 4 4 0 Helix-hairpin-helix domain Pkinase PF00069.25 KOO25469.1 - 6.9e-51 173.1 0.0 1e-50 172.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25469.1 - 9.1e-24 84.1 0.2 5.5e-22 78.3 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase RGS PF00615.19 KOO25469.1 - 3.6e-23 82.1 0.1 6.1e-23 81.3 0.1 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 KOO25469.1 - 0.00091 19.0 0.1 0.0018 18.1 0.1 1.5 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain Haspin_kinase PF12330.8 KOO25469.1 - 0.092 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain XG_FTase PF03254.13 KOO25470.1 - 0.00054 18.7 0.1 0.0011 17.7 0.0 1.4 2 0 0 2 2 2 1 Xyloglucan fucosyltransferase Rotamase PF00639.21 KOO25471.1 - 1.2e-13 51.8 0.0 2.1e-13 51.0 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOO25471.1 - 4.3e-09 36.9 0.0 8.7e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 KOO25471.1 - 0.00011 23.0 0.0 0.0002 22.2 0.0 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain Ion_trans PF00520.31 KOO25472.1 - 8e-195 644.2 32.6 1.5e-53 181.6 0.6 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO25472.1 - 3.6e-12 45.7 55.1 2.4e-07 29.8 4.4 9.4 9 1 1 10 10 10 7 Polycystin cation channel GPHH PF16905.5 KOO25472.1 - 1.4e-06 28.0 0.0 2.9e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Pentapeptide_4 PF13599.6 KOO25472.1 - 1e-05 25.6 0.0 0.12 12.5 0.0 3.3 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.18 KOO25472.1 - 0.5 10.2 1.5 25 4.7 0.1 3.2 3 1 0 3 3 3 0 Ribosomal protein L13e 5-FTHF_cyc-lig PF01812.20 KOO25474.1 - 5.9e-32 111.0 0.0 7.6e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family HypA PF01155.19 KOO25475.1 - 1.9 8.6 6.9 12 5.9 3.7 2.3 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Pkinase PF00069.25 KOO25476.1 - 1.1e-62 211.8 0.0 1.6e-62 211.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25476.1 - 2.5e-44 151.5 0.0 3.7e-44 151.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase IFT57 PF10498.9 KOO25476.1 - 9.6e-11 41.3 0.0 4.8e-07 29.1 0.2 2.1 1 1 1 2 2 2 2 Intra-flagellar transport protein 57 Kinase-like PF14531.6 KOO25476.1 - 7.9e-07 28.7 0.0 1.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO25476.1 - 7.5e-05 21.7 0.0 0.00013 20.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO25476.1 - 0.00078 18.9 0.5 0.0031 16.9 0.4 1.9 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOO25476.1 - 0.0023 16.9 0.0 0.0036 16.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOO25476.1 - 0.13 12.2 10.9 1.9 8.3 0.1 3.4 2 2 1 3 3 3 0 Phosphotransferase enzyme family HUN PF08729.10 KOO25476.1 - 0.14 12.1 0.1 0.28 11.2 0.1 1.4 1 0 0 1 1 1 0 HPC2 and ubinuclein domain CENP-P PF13096.6 KOO25476.1 - 0.19 11.4 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P CENP-H PF05837.12 KOO25476.1 - 0.73 10.3 3.8 2.4 8.6 3.9 1.9 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Asp_Arg_Hydrox PF05118.15 KOO25477.1 - 4.4e-35 120.8 0.0 5.1e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase CHIP_TPR_N PF18391.1 KOO25477.1 - 0.062 14.1 0.2 0.1 13.4 0.2 1.3 1 0 0 1 1 1 0 CHIP N-terminal tetratricopeptide repeat domain Cupin_2 PF07883.11 KOO25477.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Cupin domain Sdh5 PF03937.16 KOO25478.1 - 3.8e-23 81.2 0.3 6.7e-23 80.4 0.3 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase SAM_1 PF00536.30 KOO25480.1 - 3.4e-08 33.8 0.1 7.8e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO25480.1 - 2.4e-07 30.7 0.5 6.2e-07 29.4 0.1 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) TPR_2 PF07719.17 KOO25480.1 - 0.0068 16.4 3.5 0.47 10.7 0.1 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25480.1 - 0.017 15.8 1.9 0.017 15.8 1.9 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25480.1 - 0.017 14.9 1.0 0.91 9.5 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CENP-F_leu_zip PF10473.9 KOO25480.1 - 0.54 10.3 8.2 1.1 9.3 8.2 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1192 PF06698.11 KOO25480.1 - 0.89 9.7 9.8 1.7 8.7 0.2 3.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1192) TPR_12 PF13424.6 KOO25480.1 - 1.1 9.5 17.1 2.6 8.4 0.4 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat UAA PF08449.11 KOO25481.1 - 3.3e-37 128.3 6.7 4.1e-37 128.0 6.7 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO25481.1 - 9.9e-06 25.8 15.4 0.001 19.2 9.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 KOO25481.1 - 6.7e-05 22.4 4.4 8.2e-05 22.1 4.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family Nuc_sug_transp PF04142.15 KOO25481.1 - 0.00034 19.9 3.6 0.0034 16.6 3.6 2.0 1 1 0 1 1 1 1 Nucleotide-sugar transporter Pox_I5 PF04713.12 KOO25481.1 - 0.75 9.9 5.5 0.5 10.4 0.7 2.8 2 1 1 3 3 3 0 Poxvirus protein I5 PIH1_CS PF18201.1 KOO25482.1 - 2.9e-10 40.4 0.0 4.1e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 PIH1 CS-like domain EF-hand_1 PF00036.32 KOO25483.1 - 1e-11 43.5 0.8 5e-05 22.6 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO25483.1 - 1.5e-09 37.0 0.1 0.00065 19.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO25483.1 - 2.2e-08 34.4 0.1 4.1e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO25483.1 - 7.7e-07 28.9 0.4 0.0017 18.1 0.1 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO25483.1 - 8e-06 25.1 0.1 0.00084 18.7 0.0 2.4 2 0 0 2 2 2 1 EF hand DUF5580 PF17743.1 KOO25483.1 - 0.04 12.5 0.1 0.13 10.8 0.1 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF5580) SPARC_Ca_bdg PF10591.9 KOO25483.1 - 0.14 12.5 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Glyco_hydro_1 PF00232.18 KOO25484.1 - 5.6e-158 526.1 0.0 6.8e-158 525.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 RtcB PF01139.17 KOO25485.1 - 9.4e-113 377.5 1.5 2.2e-108 363.1 1.5 3.0 1 1 0 1 1 1 1 tRNA-splicing ligase RtcB Dev_Cell_Death PF10539.9 KOO25486.1 - 4.4e-24 84.8 0.0 5.6e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 Development and cell death domain LRR_6 PF13516.6 KOO25487.1 - 4.3e-10 38.8 14.8 0.085 13.0 0.0 7.5 7 0 0 7 7 7 3 Leucine Rich repeat ZapB PF06005.12 KOO25487.1 - 0.025 15.0 0.9 0.025 15.0 0.9 2.3 1 1 1 2 2 2 0 Cell division protein ZapB TMCO5 PF14992.6 KOO25487.1 - 0.058 13.0 2.0 0.093 12.3 2.0 1.2 1 0 0 1 1 1 0 TMCO5 family PBP_sp32 PF07222.12 KOO25487.1 - 0.093 12.2 0.0 0.093 12.2 0.0 1.9 2 0 0 2 2 2 0 Proacrosin binding protein sp32 DUF2953 PF11167.8 KOO25487.1 - 0.13 12.4 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) LRS4 PF10422.9 KOO25487.1 - 2.2 7.8 8.0 3.9 7.0 8.0 1.3 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 APG6_N PF17675.1 KOO25488.1 - 0.02 15.4 0.9 0.02 15.4 0.9 3.5 1 1 2 3 3 3 0 Apg6 coiled-coil region Fez1 PF06818.15 KOO25488.1 - 0.062 13.7 25.6 0.052 14.0 1.4 3.2 1 1 2 3 3 3 0 Fez1 RskA PF10099.9 KOO25488.1 - 0.6 10.4 10.3 0.17 12.1 5.5 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF4633 PF15464.6 KOO25488.1 - 0.76 9.9 5.7 0.53 10.4 2.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4633) GIT_CC PF16559.5 KOO25488.1 - 0.99 9.3 3.4 1 9.3 0.3 2.5 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor SHE3 PF17078.5 KOO25488.1 - 2 8.1 16.0 0.44 10.2 4.1 3.4 1 1 3 4 4 4 0 SWI5-dependent HO expression protein 3 COG2 PF06148.11 KOO25488.1 - 4 7.5 11.2 5.4 7.1 0.4 3.6 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 KOO25488.1 - 5.6 7.0 11.8 16 5.6 0.1 3.8 1 1 6 7 7 7 0 Protein of unknown function (DUF1664) TPR_11 PF13414.6 KOO25490.1 - 9.6e-27 92.4 14.8 4e-06 26.4 0.0 8.9 7 2 2 9 9 9 5 TPR repeat TPR_2 PF07719.17 KOO25490.1 - 9.5e-21 72.2 21.1 0.00017 21.4 0.3 9.7 9 2 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25490.1 - 4.1e-16 58.0 15.4 0.00017 21.3 0.1 10.2 10 1 0 10 10 10 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25490.1 - 1.6e-15 57.4 52.8 1.2e-05 25.8 0.4 7.7 4 1 1 8 8 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25490.1 - 4e-15 55.0 5.7 0.027 14.8 0.0 8.0 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25490.1 - 1.4e-14 53.0 1.7 0.3 11.4 0.0 8.4 9 1 0 9 9 9 3 Tetratricopeptide repeat PhyH PF05721.13 KOO25490.1 - 2.7e-14 53.9 0.1 4.7e-14 53.2 0.1 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) TPR_14 PF13428.6 KOO25490.1 - 1.8e-11 43.9 40.7 0.011 16.5 0.0 9.6 7 2 5 12 12 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25490.1 - 2.6e-07 30.8 27.5 0.0032 17.7 0.8 5.9 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO25490.1 - 6.6e-07 29.7 24.9 0.0055 17.2 0.3 6.3 5 1 2 7 7 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 KOO25490.1 - 8.5e-07 29.2 6.0 3.4 8.5 0.0 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO25490.1 - 0.00017 21.7 26.3 0.088 13.0 3.6 5.9 1 1 4 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO25490.1 - 0.00018 21.3 10.0 0.69 10.1 0.1 7.2 7 1 0 7 7 7 1 Tetratricopeptide repeat Ferritin_2 PF13668.6 KOO25490.1 - 0.015 15.5 0.3 0.041 14.1 0.3 1.9 1 0 0 1 1 1 0 Ferritin-like domain TPR_20 PF14561.6 KOO25490.1 - 0.19 12.1 4.3 7.4 7.0 0.0 4.2 2 1 2 4 4 4 0 Tetratricopeptide repeat Glyoxalase_6 PF18029.1 KOO25491.1 - 0.0024 18.7 0.0 0.013 16.3 0.0 2.2 2 1 0 2 2 2 1 Glyoxalase-like domain DUF3909 PF13077.6 KOO25491.1 - 0.14 12.3 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3909) Glyco_transf_34 PF05637.12 KOO25493.1 - 4.2e-28 98.7 1.1 2.4e-27 96.2 1.1 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Sulfotransfer_1 PF00685.27 KOO25493.1 - 1.3e-05 24.9 0.0 6.7e-05 22.5 0.0 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KOO25493.1 - 0.00085 19.8 0.0 0.016 15.6 0.0 2.5 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 KOO25493.1 - 0.024 14.5 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase family PAN_4 PF14295.6 KOO25494.1 - 0.072 13.0 1.5 0.18 11.7 1.5 1.7 1 0 0 1 1 1 0 PAN domain PAN_1 PF00024.26 KOO25494.1 - 0.14 12.2 1.0 0.22 11.5 0.1 1.9 2 0 0 2 2 2 0 PAN domain IFT46_B_C PF12317.8 KOO25496.1 - 0.043 13.6 0.1 0.056 13.2 0.1 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal Helicase_C PF00271.31 KOO25497.1 - 3.6e-11 43.4 0.0 8.3e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO25497.1 - 2.1e-06 27.6 0.0 4.1e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 KOO25497.1 - 0.0016 17.6 0.1 0.0029 16.7 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 KOO25497.1 - 0.002 18.4 0.7 0.018 15.3 0.7 2.3 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 KOO25497.1 - 0.0032 16.9 0.1 0.0068 15.8 0.1 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_30 PF13604.6 KOO25497.1 - 0.0059 16.3 0.1 0.022 14.5 0.1 2.0 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO25497.1 - 0.025 14.7 0.0 0.079 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KOO25497.1 - 0.026 14.8 0.1 0.078 13.3 0.1 1.8 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO25497.1 - 0.042 13.1 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 KOO25497.1 - 0.053 13.0 0.1 0.099 12.1 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 KOO25497.1 - 0.059 13.9 0.2 0.23 12.0 0.0 2.0 2 0 0 2 2 2 0 ABC transporter IstB_IS21 PF01695.17 KOO25497.1 - 0.14 11.9 0.0 7 6.3 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein DAP3 PF10236.9 KOO25497.1 - 0.22 10.7 0.0 0.37 9.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_23 PF13476.6 KOO25497.1 - 0.22 12.0 0.0 0.36 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arm PF00514.23 KOO25498.1 - 4.4e-14 52.0 12.2 0.00026 20.9 0.2 5.9 5 1 0 5 5 5 4 Armadillo/beta-catenin-like repeat RICTOR_N PF14664.6 KOO25498.1 - 0.00039 19.5 0.2 0.00064 18.8 0.2 1.4 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term KAP PF05804.12 KOO25498.1 - 0.028 12.6 1.2 4.5 5.3 0.0 2.1 1 1 0 2 2 2 0 Kinesin-associated protein (KAP) TM1506 PF08973.10 KOO25498.1 - 0.051 13.3 0.2 0.18 11.5 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1893) HEAT_EZ PF13513.6 KOO25498.1 - 0.072 13.6 8.7 0.26 11.9 0.1 3.8 4 0 0 4 4 4 0 HEAT-like repeat HEAT_2 PF13646.6 KOO25498.1 - 1.9 8.9 7.0 6.9 7.1 0.0 3.7 2 1 1 3 3 3 0 HEAT repeats F-box PF00646.33 KOO25499.1 - 0.0026 17.6 0.4 0.0055 16.5 0.4 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOO25499.1 - 0.0076 16.1 0.3 0.02 14.8 0.3 1.7 1 0 0 1 1 1 1 F-box-like FHA PF00498.26 KOO25499.1 - 0.018 15.3 0.4 0.11 12.8 0.4 2.1 1 1 0 1 1 1 0 FHA domain HSBP1 PF06825.12 KOO25500.1 - 8.3e-27 92.8 1.0 9.9e-27 92.6 1.0 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 YvrJ PF12841.7 KOO25500.1 - 0.19 11.3 0.0 0.85 9.2 0.0 1.9 2 0 0 2 2 2 0 YvrJ protein family IL11 PF07400.11 KOO25500.1 - 0.2 11.3 0.0 0.35 10.5 0.0 1.4 1 1 0 1 1 1 0 Interleukin 11 Ank_2 PF12796.7 KOO25501.1 - 1.3e-12 48.1 0.3 6.4e-06 26.7 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO25501.1 - 3e-12 46.4 0.2 5.7e-06 26.5 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO25501.1 - 3e-12 45.6 0.1 9.6e-05 22.5 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KOO25501.1 - 3.3e-12 46.4 0.4 1.6e-08 34.6 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_6 PF13405.6 KOO25501.1 - 1.8e-11 43.0 0.5 6.7e-05 22.5 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO25501.1 - 8.7e-11 42.1 6.9 1.1e-07 32.2 0.4 2.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO25501.1 - 1.7e-09 36.5 0.2 0.00069 19.0 0.2 2.6 2 0 0 2 2 2 2 EF hand Ank_4 PF13637.6 KOO25501.1 - 1.5e-08 35.0 0.1 6.4e-08 33.0 0.1 2.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) ART PF01129.18 KOO25501.1 - 1.3e-06 27.9 0.0 2.9e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase EF-hand_8 PF13833.6 KOO25501.1 - 2.5e-06 27.2 0.1 1e-05 25.3 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO25501.1 - 9.2e-05 21.8 0.6 0.11 12.0 0.6 2.6 2 0 0 2 2 2 2 EF hand ADPrib_exo_Tox PF03496.14 KOO25501.1 - 9.8e-05 21.8 0.0 0.0003 20.2 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme LRR_6 PF13516.6 KOO25501.1 - 0.00034 20.4 0.0 0.0016 18.4 0.0 2.3 1 0 0 1 1 1 1 Leucine Rich repeat DUF1707 PF08044.11 KOO25501.1 - 0.37 10.9 2.1 0.98 9.5 0.0 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF1707) ABC1 PF03109.16 KOO25502.1 - 9.8e-16 58.0 0.0 3.4e-15 56.3 0.0 1.9 2 0 0 2 2 2 1 ABC1 family Beta-lactamase PF00144.24 KOO25502.1 - 0.0095 15.2 1.7 0.016 14.5 1.7 1.3 1 0 0 1 1 1 1 Beta-lactamase Pkinase PF00069.25 KOO25502.1 - 0.033 13.5 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Glyco_hydro_3_C PF01915.22 KOO25503.1 - 0.055 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain EF-hand_6 PF13405.6 KOO25504.1 - 5.2e-22 75.9 21.6 0.00032 20.4 0.0 8.6 9 0 0 9 9 9 6 EF-hand domain EF-hand_1 PF00036.32 KOO25504.1 - 5.1e-20 69.5 28.4 1.2e-05 24.5 0.1 8.3 8 1 0 8 8 8 4 EF hand EF-hand_7 PF13499.6 KOO25504.1 - 8.1e-20 71.1 12.8 3.2e-08 33.9 0.8 5.7 3 3 2 5 5 5 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO25504.1 - 1.5e-15 56.8 18.9 0.0051 16.6 2.6 6.8 6 1 1 7 7 7 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO25504.1 - 1.2e-14 53.0 17.7 3.6e-05 23.1 0.3 5.9 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 KOO25504.1 - 0.0008 19.7 0.2 0.043 14.1 0.0 3.2 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO25504.1 - 0.017 15.5 1.5 2.3 8.6 0.0 4.0 5 0 0 5 5 5 0 EF-hand domain Dockerin_1 PF00404.18 KOO25504.1 - 0.14 12.4 8.9 13 6.0 0.0 5.3 6 0 0 6 6 6 0 Dockerin type I domain Mito_carr PF00153.27 KOO25505.1 - 1.2e-48 163.0 2.2 5.8e-19 67.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOO25505.1 - 0.06 12.5 0.0 0.23 10.6 0.0 1.9 2 0 0 2 2 2 0 Gammaproteobacterial serine protease SUIM_assoc PF16619.5 KOO25505.1 - 0.08 13.0 1.3 0.18 11.9 1.3 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TTL PF03133.15 KOO25506.1 - 1.7e-49 168.6 0.0 2.7e-49 167.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO25506.1 - 1.4e-07 31.0 0.0 0.017 14.4 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp Ank_2 PF12796.7 KOO25507.1 - 3.2e-21 75.7 1.0 4.6e-12 46.4 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO25507.1 - 4.4e-17 62.2 0.8 2e-10 41.0 0.2 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO25507.1 - 6.8e-17 61.3 2.2 8.9e-12 45.0 0.3 3.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO25507.1 - 1.1e-14 53.0 0.0 0.00032 20.9 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO25507.1 - 6.8e-14 51.6 0.2 0.0001 22.6 0.1 3.7 4 0 0 4 4 4 2 Ankyrin repeat GYF PF02213.16 KOO25510.1 - 4.1e-46 154.4 0.0 3.1e-11 42.8 0.0 5.4 5 0 0 5 5 5 5 GYF domain GYF_2 PF14237.6 KOO25510.1 - 3.7e-22 77.9 7.7 0.00049 19.8 0.0 6.3 6 0 0 6 6 6 5 GYF domain 2 Alveol-reg_P311 PF11092.8 KOO25510.1 - 0.042 14.0 0.0 11 6.2 0.0 3.5 3 0 0 3 3 3 0 Neuronal protein 3.1 (p311) EF-hand_1 PF00036.32 KOO25511.1 - 3.2e-27 92.0 8.0 9.2e-07 28.0 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO25511.1 - 1.4e-25 89.5 3.5 2.2e-13 50.5 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO25511.1 - 3.4e-23 79.6 7.6 1.8e-06 27.4 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO25511.1 - 3.4e-22 76.9 12.5 1.2e-05 24.6 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO25511.1 - 6.3e-19 67.6 11.7 6.3e-08 32.4 0.7 4.2 2 2 2 4 4 4 4 EF-hand domain pair Pkinase PF00069.25 KOO25511.1 - 5.2e-14 52.2 0.0 7e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SPARC_Ca_bdg PF10591.9 KOO25511.1 - 8.7e-07 29.3 0.0 0.0021 18.4 0.0 2.5 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO25511.1 - 1.1e-05 25.3 1.6 0.0045 16.9 0.0 3.4 1 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 KOO25511.1 - 7.6e-05 22.7 0.2 3.1 7.7 0.0 3.3 2 1 1 3 3 3 2 Caleosin related protein EF-hand_9 PF14658.6 KOO25511.1 - 0.0051 17.1 0.3 1.9 8.9 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain TerB PF05099.13 KOO25511.1 - 0.011 15.7 1.7 0.13 12.2 0.2 2.7 1 1 1 2 2 2 0 Tellurite resistance protein TerB Pkinase_Tyr PF07714.17 KOO25511.1 - 0.026 13.8 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase EF-hand_14 PF17959.1 KOO25511.1 - 0.04 14.2 0.2 16 5.9 0.0 2.7 2 1 0 2 2 2 0 EF-hand domain RAMP4 PF06624.12 KOO25511.1 - 0.086 12.9 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Ribosome associated membrane protein RAMP4 Dockerin_1 PF00404.18 KOO25511.1 - 0.18 12.0 1.3 20 5.5 0.1 2.9 2 1 1 3 3 3 0 Dockerin type I domain HA2 PF04408.23 KOO25512.1 - 2.9e-19 69.4 0.0 2.9e-19 69.4 0.0 3.4 3 1 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOO25512.1 - 6.1e-19 68.2 0.1 1.4e-18 67.0 0.1 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOO25512.1 - 3.8e-13 49.8 0.0 9.5e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO25512.1 - 3.1e-05 23.8 0.0 0.00025 20.8 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOO25512.1 - 0.00023 21.5 0.2 0.0013 19.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KOO25512.1 - 0.0012 17.9 0.0 0.0028 16.8 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein PWI PF01480.17 KOO25512.1 - 0.026 14.9 0.0 0.084 13.2 0.0 1.9 1 0 0 1 1 1 0 PWI domain AAA_19 PF13245.6 KOO25512.1 - 0.028 14.8 0.0 0.072 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOO25512.1 - 0.058 13.9 0.2 0.49 10.9 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_23 PF13476.6 KOO25512.1 - 0.51 10.8 0.0 0.51 10.8 0.0 3.5 3 1 0 3 3 1 0 AAA domain PRTP PF01366.18 KOO25512.1 - 3.7 5.5 7.9 6.6 4.6 7.9 1.4 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Lipase_GDSL_2 PF13472.6 KOO25513.1 - 0.008 16.6 0.0 0.036 14.4 0.0 2.1 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family RRM_1 PF00076.22 KOO25515.1 - 1.5e-21 76.0 0.0 1.5e-11 44.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.11 KOO25515.1 - 0.0004 20.5 0.0 0.00094 19.3 0.0 1.6 1 0 0 1 1 1 1 NOPS (NUC059) domain DUF896 PF05979.12 KOO25515.1 - 0.26 11.2 4.5 0.68 9.8 4.5 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) CRAL_TRIO PF00650.20 KOO25516.1 - 9.9e-10 38.4 0.0 1.6e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain DUF1279 PF06916.13 KOO25517.1 - 3e-18 66.1 0.3 8.4e-18 64.7 0.3 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) PAP_fibrillin PF04755.12 KOO25518.1 - 8.9e-11 42.1 0.0 5.2e-09 36.3 0.0 2.3 1 1 0 1 1 1 1 PAP_fibrillin Thioredoxin PF00085.20 KOO25520.1 - 1.8e-17 63.2 0.0 3.2e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 KOO25520.1 - 3.7e-07 30.1 0.0 6.8e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 KOO25520.1 - 0.00044 20.4 0.0 0.002 18.2 0.0 2.0 2 1 0 2 2 2 1 Thioredoxin-like ClpS PF02617.17 KOO25520.1 - 0.00061 19.5 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS Redoxin PF08534.10 KOO25520.1 - 0.00063 19.5 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 KOO25520.1 - 0.0015 18.8 0.0 0.0048 17.2 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 KOO25520.1 - 0.006 17.0 0.0 0.19 12.2 0.0 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KOO25520.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin TraF PF13728.6 KOO25520.1 - 0.03 14.2 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 F plasmid transfer operon protein HGD-D PF06050.13 KOO25520.1 - 0.046 13.5 0.0 1.6 8.5 0.0 2.0 1 1 1 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component Glutaredoxin PF00462.24 KOO25520.1 - 0.061 13.6 0.0 0.35 11.1 0.0 2.2 2 1 0 2 2 2 0 Glutaredoxin Foie-gras_1 PF11817.8 KOO25522.1 - 7.2e-32 111.0 3.3 1.1e-31 110.4 3.3 1.3 1 0 0 1 1 1 1 Foie gras liver health family 1 TRAPPC-Trs85 PF12739.7 KOO25522.1 - 0.0074 15.3 4.4 0.013 14.5 4.4 1.5 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Gryzun-like PF12742.7 KOO25522.1 - 0.0089 16.0 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking DUF842 PF05811.13 KOO25522.1 - 0.03 14.0 0.1 0.065 12.9 0.1 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) DUF11 PF01345.18 KOO25522.1 - 0.14 12.5 2.6 45 4.5 0.1 4.8 3 1 1 4 4 4 0 Domain of unknown function DUF11 EF-hand_6 PF13405.6 KOO25523.1 - 1.4e-08 34.0 0.4 0.00042 20.0 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO25523.1 - 2.8e-08 32.8 0.3 5.4e-05 22.4 0.0 2.9 2 1 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO25523.1 - 5.5e-07 29.9 1.9 6.6e-06 26.5 1.8 2.3 1 1 1 2 2 2 2 EF-hand domain pair RHD3 PF05879.12 KOO25523.1 - 1.5e-06 26.8 0.6 1.9e-06 26.4 0.6 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) EF-hand_8 PF13833.6 KOO25523.1 - 1e-05 25.3 1.9 2.1e-05 24.2 0.1 2.5 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO25523.1 - 0.00013 21.3 3.5 0.25 10.9 0.4 3.0 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 KOO25523.1 - 0.032 14.6 0.0 0.083 13.2 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_10 PF14788.6 KOO25523.1 - 0.078 12.9 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 EF hand VWA_2 PF13519.6 KOO25524.1 - 1.5e-21 77.1 0.2 3.8e-21 75.8 0.1 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.14 KOO25524.1 - 5e-07 29.7 0.0 7e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 KOO25524.1 - 9.8e-05 22.7 0.1 0.00015 22.1 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Glyco_transf_90 PF05686.12 KOO25525.1 - 6.2e-34 117.6 0.0 8.3e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 KOO25525.1 - 0.0012 19.2 0.0 0.0023 18.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Aa_trans PF01490.18 KOO25526.1 - 1.1e-47 162.7 20.0 1.4e-47 162.4 20.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOO25526.1 - 2.3e-07 30.2 5.3 2.3e-07 30.2 5.3 2.6 3 0 0 3 3 3 2 Tryptophan/tyrosine permease family CBF PF03914.17 KOO25528.1 - 0.0063 16.6 0.1 0.015 15.3 0.1 1.5 1 1 0 1 1 1 1 CBF/Mak21 family OS-D PF03392.13 KOO25528.1 - 0.046 13.8 0.1 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Insect pheromone-binding family, A10/OS-D Bgal_small_N PF02929.17 KOO25531.1 - 1.8e-18 67.0 0.0 2.3e-18 66.7 0.0 1.0 1 0 0 1 1 1 1 Beta galactosidase small chain EF-hand_6 PF13405.6 KOO25532.1 - 3.8e-37 123.0 0.8 0.00013 21.6 0.1 8.4 8 0 0 8 8 8 8 EF-hand domain EF-hand_7 PF13499.6 KOO25532.1 - 1e-32 112.4 0.4 1.7e-07 31.6 0.0 5.6 5 1 0 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.32 KOO25532.1 - 1e-31 106.1 0.7 0.00019 20.7 0.1 8.3 8 0 0 8 8 8 8 EF hand EF-hand_8 PF13833.6 KOO25532.1 - 4.7e-23 80.8 1.0 0.00025 20.8 0.1 5.8 4 2 2 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO25532.1 - 1.6e-15 55.8 12.4 0.0071 15.8 0.5 7.9 8 0 0 8 8 8 5 EF hand SPARC_Ca_bdg PF10591.9 KOO25532.1 - 4.8e-05 23.6 0.0 1.2 9.5 0.0 4.2 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO25532.1 - 0.0014 18.6 0.0 0.99 9.3 0.0 4.0 3 2 1 4 4 4 1 Caleosin related protein EF-hand_9 PF14658.6 KOO25532.1 - 0.0015 18.8 0.0 2.8 8.4 0.0 4.3 4 0 0 4 4 4 1 EF-hand domain STAS_2 PF13466.6 KOO25532.1 - 9.4 6.7 8.6 18 5.8 0.1 4.4 5 0 0 5 5 5 0 STAS domain RGS PF00615.19 KOO25533.1 - 3.7e-17 62.7 0.0 1.5e-13 51.0 0.0 4.0 3 1 0 3 3 3 2 Regulator of G protein signaling domain PH PF00169.29 KOO25533.1 - 1.7e-05 25.3 0.0 0.0047 17.4 0.0 2.4 2 0 0 2 2 2 2 PH domain PH_2 PF08458.10 KOO25533.1 - 0.14 12.5 0.3 0.41 11.0 0.0 2.0 2 0 0 2 2 2 0 Plant pleckstrin homology-like region VCH_CASS14 PF18315.1 KOO25534.1 - 0.035 14.2 0.0 53 4.0 0.0 3.5 1 1 2 3 3 3 0 Integron cassette protein VCH_CASS1 chain DUF1521 PF07481.11 KOO25534.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1521) DUF4267 PF14087.6 KOO25535.1 - 9.9e-11 41.7 1.9 9.9e-11 41.7 1.9 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4267) RRM_1 PF00076.22 KOO25537.1 - 1.9e-28 98.1 0.6 1.6e-13 50.2 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOO25537.1 - 4.6e-09 35.9 0.0 0.0019 17.8 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO25537.1 - 1.3e-07 31.4 0.0 0.0019 18.0 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif SIMPL PF04402.14 KOO25537.1 - 5.7e-05 23.7 0.7 7.3e-05 23.3 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF541) DUF4523 PF15023.6 KOO25537.1 - 8.8e-05 22.4 0.0 0.0002 21.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) PHM7_cyt PF14703.6 KOO25537.1 - 0.35 11.1 2.0 12 6.0 0.1 2.8 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter ISG65-75 PF11727.8 KOO25537.1 - 1.1 8.4 5.3 1.6 7.9 5.3 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein SAP30_Sin3_bdg PF13867.6 KOO25538.1 - 4.6e-19 68.5 0.7 6.9e-19 67.9 0.7 1.3 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Staygreen PF12638.7 KOO25538.1 - 0.11 12.3 0.3 0.14 12.0 0.3 1.1 1 0 0 1 1 1 0 Staygreen protein Acyl_transf_3 PF01757.22 KOO25539.1 - 0.029 13.4 13.8 0.064 12.3 13.8 1.6 1 1 0 1 1 1 0 Acyltransferase family PX PF00787.24 KOO25541.1 - 3.3e-17 62.5 0.1 5.3e-17 61.8 0.1 1.3 1 0 0 1 1 1 1 PX domain Jak1_Phl PF17887.1 KOO25541.1 - 0.097 12.6 0.2 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain Arena_ncap_C PF17290.2 KOO25541.1 - 0.15 11.4 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Arenavirus nucleocapsid C-terminal domain Nucleotid_trans PF03407.16 KOO25543.1 - 0.073 13.0 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase VWA_CoxE PF05762.14 KOO25543.1 - 0.2 11.0 1.4 0.18 11.1 0.2 1.5 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein Ank_4 PF13637.6 KOO25544.1 - 4e-25 87.9 0.3 1.4e-09 38.3 0.0 3.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO25544.1 - 2e-21 76.4 0.0 3.8e-10 40.2 0.0 2.6 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO25544.1 - 4.7e-18 63.4 0.0 0.00053 20.2 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO25544.1 - 5.5e-18 64.8 0.6 1.7e-07 31.3 0.0 3.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO25544.1 - 1.8e-17 62.9 0.2 4.5e-06 26.9 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat FemAB_like PF04339.12 KOO25544.1 - 0.17 10.9 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition Reticulon PF02453.17 KOO25545.1 - 4.6e-08 33.2 0.1 6e-08 32.8 0.1 1.2 1 0 0 1 1 1 1 Reticulon PGG PF13962.6 KOO25545.1 - 0.028 14.2 0.0 0.039 13.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function Peptidase_M50B PF13398.6 KOO25545.1 - 0.03 14.0 0.2 0.034 13.8 0.2 1.1 1 0 0 1 1 1 0 Peptidase M50B-like DUF4051 PF13260.6 KOO25545.1 - 0.059 13.1 0.1 0.086 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) TPR_2 PF07719.17 KOO25546.1 - 2.3e-08 33.5 3.0 0.02 15.0 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO25546.1 - 2.2e-07 31.3 2.0 0.0023 18.4 0.3 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25546.1 - 1.4e-06 28.8 9.2 0.0018 18.9 0.9 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25546.1 - 1.1e-05 25.6 2.8 0.00039 20.7 0.5 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO25546.1 - 1.8e-05 24.8 2.1 0.0073 16.4 0.0 2.5 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO25546.1 - 4e-05 24.1 7.0 0.0014 19.3 0.7 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25546.1 - 5.2e-05 22.9 1.1 0.016 15.0 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO25546.1 - 8.8e-05 22.2 4.4 0.094 12.6 0.0 3.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25546.1 - 0.00013 21.9 0.9 1.4 9.4 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO25546.1 - 0.00017 21.2 1.5 0.057 13.1 0.1 3.0 2 1 1 3 3 3 1 TPR repeat TPR_4 PF07721.14 KOO25546.1 - 0.00021 21.6 2.6 0.14 12.8 1.8 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25546.1 - 0.008 16.5 0.1 0.12 12.8 0.1 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOO25546.1 - 0.057 14.1 0.1 0.41 11.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO25546.1 - 0.07 13.4 0.8 0.15 12.3 0.1 2.0 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 KOO25546.1 - 0.074 12.7 0.1 1.5 8.5 0.0 2.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_7 PF13176.6 KOO25546.1 - 0.081 13.0 1.7 1.5 9.0 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 KOO25546.1 - 0.41 11.1 3.3 6.7 7.1 3.3 2.5 1 1 0 1 1 1 0 Bacterial transcriptional activator domain AAA PF00004.29 KOO25549.1 - 6.4e-10 39.6 0.0 1.2e-09 38.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOO25549.1 - 0.0015 18.3 0.0 0.003 17.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 KOO25549.1 - 0.0025 17.4 0.2 0.016 14.8 0.0 2.3 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 KOO25549.1 - 0.011 16.1 0.0 0.022 15.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 KOO25549.1 - 0.015 15.7 0.9 0.053 13.9 0.1 2.3 1 1 1 2 2 2 0 AAA ATPase domain ATPase PF06745.13 KOO25549.1 - 0.019 14.3 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 KOO25549.1 - 0.02 15.5 0.0 0.051 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOO25549.1 - 0.034 13.8 0.2 0.063 13.0 0.2 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOO25549.1 - 0.035 14.6 0.0 0.07 13.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 KOO25549.1 - 0.07 13.1 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 KOO25549.1 - 0.076 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KOO25549.1 - 0.088 13.0 0.2 0.53 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Bombinin PF05298.11 KOO25549.1 - 0.09 12.5 0.3 4.4 7.0 0.0 2.3 2 0 0 2 2 2 0 Bombinin Rad17 PF03215.15 KOO25549.1 - 0.096 12.6 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain RSN1_7TM PF02714.15 KOO25550.1 - 0.00033 20.1 0.6 0.0008 18.8 0.6 1.6 1 1 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 KOO25550.1 - 0.0059 16.9 0.0 0.0093 16.2 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter AmoC PF04896.12 KOO25550.1 - 0.013 14.8 0.1 0.024 13.9 0.1 1.4 1 0 0 1 1 1 0 Ammonia monooxygenase/methane monooxygenase, subunit C MLTD_N PF06474.12 KOO25550.1 - 2.9 8.1 4.6 43 4.4 0.1 2.8 2 0 0 2 2 2 0 MltD lipid attachment motif zf-trcl PF13451.6 KOO25551.1 - 3.3e-05 23.7 0.2 6e-05 22.8 0.2 1.5 1 0 0 1 1 1 1 Probable zinc-ribbon domain DUF3761 PF12587.8 KOO25551.1 - 0.16 12.4 1.1 0.28 11.7 0.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3761) PsbW PF07123.12 KOO25551.1 - 0.35 10.9 1.2 0.49 10.4 1.2 1.1 1 0 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) DUF3138 PF11336.8 KOO25551.1 - 0.52 8.9 2.7 0.63 8.6 2.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF498 PF04430.14 KOO25552.1 - 0.034 14.2 0.0 0.064 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) Peptidase_S24 PF00717.23 KOO25552.1 - 0.044 13.7 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Peptidase S24-like HydF_dimer PF18128.1 KOO25552.1 - 0.21 11.7 0.0 0.32 11.1 0.0 1.3 1 0 0 1 1 1 0 Hydrogen maturase F dimerization domain Ank_4 PF13637.6 KOO25554.1 - 1.2e-22 80.0 2.8 1.3e-06 28.8 0.0 4.2 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO25554.1 - 2.1e-21 76.3 4.0 7e-15 55.4 1.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO25554.1 - 7e-19 67.4 12.0 1.1e-05 25.6 0.2 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KOO25554.1 - 8.7e-19 67.3 7.9 1.4e-06 28.4 0.3 4.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO25554.1 - 1e-15 56.2 2.4 0.00023 21.3 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat NHL PF01436.21 KOO25555.1 - 1.8e-26 90.8 17.6 2.7e-06 27.1 1.4 6.2 6 0 0 6 6 6 5 NHL repeat SGL PF08450.12 KOO25555.1 - 0.00098 18.8 0.1 0.23 11.0 0.0 3.2 2 2 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region CEP63 PF17045.5 KOO25555.1 - 0.046 13.6 1.3 0.061 13.2 1.3 1.1 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa Lebercilin PF15619.6 KOO25555.1 - 0.062 13.0 6.3 0.083 12.5 6.3 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease NAD_binding_10 PF13460.6 KOO25556.1 - 1.3e-22 80.6 0.1 8.7e-13 48.6 0.1 2.8 3 0 0 3 3 3 2 NAD(P)H-binding CIA30 PF08547.12 KOO25556.1 - 3.8e-14 53.0 0.0 6.5e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) NmrA PF05368.13 KOO25556.1 - 9.6e-07 28.6 0.0 3.4e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family PDEase_I PF00233.19 KOO25557.1 - 4.5e-78 262.3 0.3 6.7e-78 261.7 0.3 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Ion_trans PF00520.31 KOO25557.1 - 4.4e-09 35.9 17.1 7.3e-09 35.2 17.1 1.3 1 0 0 1 1 1 1 Ion transport protein C2 PF00168.30 KOO25559.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.7 1 1 0 1 1 1 0 C2 domain Peptidase_C48 PF02902.19 KOO25560.1 - 1.1e-22 81.0 0.0 3.2e-21 76.2 0.0 2.7 2 1 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain ubiquitin PF00240.23 KOO25561.1 - 6.5e-12 45.0 0.1 1.1e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOO25561.1 - 0.0018 18.0 0.0 0.0033 17.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Pilosulin PF17499.2 KOO25561.1 - 0.17 12.1 0.1 0.36 11.0 0.1 1.5 1 0 0 1 1 1 0 Ant venom peptides Rad60-SLD PF11976.8 KOO25562.1 - 2.3e-21 75.4 0.0 3.7e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.20 KOO25562.1 - 2.3e-13 50.2 0.0 3.6e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ubiquitin PF00240.23 KOO25562.1 - 1.9e-10 40.3 0.0 3.3e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family WWE PF02825.20 KOO25562.1 - 7.8e-08 32.8 0.1 1.7e-07 31.7 0.1 1.6 1 0 0 1 1 1 1 WWE domain Exotox-A_cataly PF09009.10 KOO25562.1 - 0.036 13.8 0.0 0.098 12.4 0.0 1.7 2 0 0 2 2 2 0 Exotoxin A catalytic Pentapeptide_4 PF13599.6 KOO25563.1 - 7.8e-12 45.2 0.0 1.9e-05 24.7 0.0 2.2 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) GramPos_pilinD1 PF16555.5 KOO25563.1 - 0.0023 18.1 0.2 0.043 14.0 0.2 2.2 1 1 0 1 1 1 1 Gram-positive pilin subunit D1, N-terminal domain Ribosomal_L13e PF01294.18 KOO25563.1 - 0.0026 17.6 1.3 12 5.8 0.0 4.4 2 2 5 7 7 7 1 Ribosomal protein L13e Ntox33 PF15533.6 KOO25563.1 - 0.0029 18.0 0.3 3.8 8.1 0.1 3.8 3 1 1 4 4 4 1 Bacterial toxin 33 SAM_2 PF07647.17 KOO25563.1 - 0.023 14.8 0.0 5.5 7.2 0.0 3.4 2 2 0 2 2 2 0 SAM domain (Sterile alpha motif) Clp_N PF02861.20 KOO25563.1 - 0.24 11.6 3.5 6.2 7.0 0.1 3.6 4 1 1 5 5 5 0 Clp amino terminal domain, pathogenicity island component LRR_4 PF12799.7 KOO25564.1 - 9.3e-17 60.9 47.9 0.0003 21.1 3.2 13.7 13 1 1 14 14 14 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO25564.1 - 6.1e-15 53.9 66.0 0.05 13.7 0.5 20.7 23 0 0 23 23 23 7 Leucine Rich repeat LRR_8 PF13855.6 KOO25564.1 - 6.2e-09 35.5 46.8 1.9e-05 24.3 2.5 11.9 13 3 1 14 14 14 4 Leucine rich repeat AAA_19 PF13245.6 KOO25564.1 - 0.025 14.9 0.1 0.15 12.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain LRR_9 PF14580.6 KOO25564.1 - 0.038 13.5 3.8 3.3 7.2 0.3 3.5 2 1 1 3 3 3 0 Leucine-rich repeat V_ATPase_I PF01496.19 KOO25564.1 - 3.6 5.4 4.7 6.8 4.5 4.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LRR_1 PF00560.33 KOO25564.1 - 5.6 7.9 34.1 73 4.5 0.1 13.3 14 1 0 14 14 14 0 Leucine Rich Repeat VDE PF07137.11 KOO25565.1 - 2.8e-25 89.2 0.0 4.3e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 VDE lipocalin domain DUF3479 PF11965.8 KOO25565.1 - 0.074 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) Profilin PF00235.19 KOO25566.1 - 6.8e-23 81.3 0.9 3.1e-13 50.1 0.0 2.0 2 0 0 2 2 2 2 Profilin DUF3533 PF12051.8 KOO25567.1 - 0.17 10.8 0.6 0.24 10.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) DUF3720 PF12517.8 KOO25567.1 - 3.4 8.7 8.5 0.32 12.0 3.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3720) FtsJ PF01728.19 KOO25568.1 - 1.3e-53 181.8 0.1 1.9e-53 181.2 0.1 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 KOO25568.1 - 5.1e-31 107.7 4.6 5.1e-31 107.7 4.6 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 KOO25568.1 - 0.054 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MRC1 PF09444.10 KOO25568.1 - 0.34 11.4 29.8 0.8 10.2 2.3 3.4 3 0 0 3 3 3 0 MRC1-like domain Scm3 PF10384.9 KOO25569.1 - 0.093 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Centromere protein Scm3 SHIPPO-rpt PF07004.12 KOO25570.1 - 4.4e-08 33.7 19.2 2.2 9.4 0.2 6.5 6 0 0 6 6 6 5 Sperm-tail PG-rich repeat GST_N_3 PF13417.6 KOO25571.1 - 1.7e-07 31.6 0.0 2.9e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 KOO25571.1 - 2.4e-07 30.9 0.0 4.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_C_2 PF13410.6 KOO25571.1 - 1.6e-05 24.9 0.0 4e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KOO25571.1 - 5.9e-05 23.3 0.0 0.00011 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 KOO25571.1 - 0.0015 19.2 0.0 0.0036 18.0 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C PF00043.25 KOO25571.1 - 0.054 13.7 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 KOO25571.1 - 0.058 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOO25571.1 - 0.06 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Pkinase PF00069.25 KOO25572.1 - 7e-56 189.5 0.0 8e-56 189.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25572.1 - 3.8e-46 157.5 0.0 4.9e-46 157.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO25572.1 - 3.9e-05 23.7 2.5 0.061 13.2 0.6 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO25572.1 - 0.087 12.1 0.1 0.44 9.8 0.1 1.8 2 0 0 2 2 2 0 Kinase-like DPPIV_N PF00930.21 KOO25576.1 - 5.5e-65 219.4 0.0 5.4e-63 212.9 0.0 2.2 2 0 0 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 KOO25576.1 - 2.1e-54 184.2 0.2 5.8e-54 182.8 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 KOO25576.1 - 8.2e-12 45.3 1.0 2e-10 40.7 0.3 2.7 2 1 1 3 3 3 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 KOO25576.1 - 0.00024 20.8 0.0 0.00058 19.5 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 KOO25576.1 - 0.0015 19.2 0.1 0.0015 19.2 0.1 2.7 1 1 2 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO25576.1 - 0.0075 15.9 0.1 0.017 14.8 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO25576.1 - 0.0096 15.2 0.1 0.024 13.9 0.1 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2048 PF09752.9 KOO25576.1 - 0.014 14.5 0.1 0.022 13.9 0.1 1.2 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Esterase PF00756.20 KOO25576.1 - 0.035 13.8 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DUF3141 PF11339.8 KOO25576.1 - 0.074 11.5 0.3 0.11 10.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) BAAT_C PF08840.11 KOO25576.1 - 0.18 11.7 0.1 5 7.0 0.0 2.3 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S28 PF05577.12 KOO25576.1 - 0.24 10.1 0.1 0.36 9.6 0.1 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 EF-hand_6 PF13405.6 KOO25577.1 - 1.2e-19 68.5 16.2 4.6e-05 23.0 0.0 7.0 7 0 0 7 7 7 5 EF-hand domain EF-hand_7 PF13499.6 KOO25577.1 - 1.6e-18 66.9 10.7 1e-07 32.3 0.0 4.5 3 2 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO25577.1 - 3.1e-17 60.7 12.3 0.00027 20.3 0.0 6.3 6 0 0 6 6 6 4 EF hand EF-hand_5 PF13202.6 KOO25577.1 - 1.5e-11 43.2 14.7 0.0031 17.0 0.1 5.8 6 0 0 6 6 6 3 EF hand EF-hand_8 PF13833.6 KOO25577.1 - 5.8e-11 42.1 5.2 0.00085 19.1 0.1 5.1 4 1 1 5 5 5 4 EF-hand domain pair EF-hand_4 PF12763.7 KOO25577.1 - 0.43 10.6 2.6 4.2 7.4 0.1 3.1 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Ribonuc_L-PSP PF01042.21 KOO25578.1 - 3.8e-26 91.5 0.0 5.1e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP EF-hand_7 PF13499.6 KOO25580.1 - 5.6e-17 62.0 6.9 3.6e-07 30.5 0.1 5.1 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO25580.1 - 3.2e-16 57.8 7.4 0.00029 20.5 0.0 5.7 5 1 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KOO25580.1 - 1.9e-13 49.2 1.2 1e-05 24.8 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_1 PF00036.32 KOO25580.1 - 4.3e-13 47.8 12.3 0.00058 19.2 0.5 5.9 7 0 0 7 7 7 4 EF hand EF-hand_8 PF13833.6 KOO25580.1 - 1.1e-10 41.1 6.3 0.084 12.7 0.0 5.1 4 1 1 5 5 5 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO25580.1 - 0.043 14.1 0.0 0.45 10.9 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain Caleosin PF05042.13 KOO25580.1 - 0.15 12.0 0.3 11 5.9 0.1 2.8 2 1 0 3 3 3 0 Caleosin related protein EF-hand_6 PF13405.6 KOO25582.1 - 3.7e-26 88.8 2.1 9.2e-06 25.2 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO25582.1 - 4.3e-25 85.3 4.4 3.4e-05 23.1 0.0 4.6 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO25582.1 - 2.2e-22 79.3 0.3 1.4e-09 38.3 0.3 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO25582.1 - 2.2e-20 71.2 14.5 2e-06 27.0 0.2 5.0 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO25582.1 - 1.5e-18 66.3 0.2 0.0003 20.6 0.0 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO25582.1 - 0.0017 18.7 0.0 0.07 13.5 0.0 2.8 2 1 0 2 2 2 1 EF-hand domain EF-hand_14 PF17959.1 KOO25582.1 - 0.016 15.5 0.1 15 6.1 0.0 3.1 2 1 1 3 3 3 0 EF-hand domain EF-hand_11 PF08976.11 KOO25582.1 - 0.078 13.8 0.0 0.39 11.6 0.0 2.1 2 1 0 2 2 2 0 EF-hand domain TetR_C_31 PF17940.1 KOO25582.1 - 0.28 11.4 4.3 0.94 9.7 1.7 2.7 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Peptidase_M17 PF00883.21 KOO25583.1 - 4.2e-60 203.6 0.0 4.8e-60 203.4 0.0 1.0 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain AdoMet_MTase PF07757.13 KOO25583.1 - 0.067 13.5 0.7 0.12 12.7 0.7 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase PAS_9 PF13426.7 KOO25584.1 - 1.6e-06 28.3 0.0 2.2e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 PAS domain Homeodomain PF00046.29 KOO25584.1 - 0.0039 17.0 0.1 0.089 12.6 0.0 2.3 2 0 0 2 2 2 1 Homeodomain YdaS_antitoxin PF15943.5 KOO25584.1 - 0.099 12.5 0.0 19 5.2 0.0 2.3 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Thr_synth_N PF14821.6 KOO25585.1 - 9.3e-17 61.0 0.0 1.8e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 KOO25585.1 - 8.6e-16 58.2 0.1 1.9e-15 57.1 0.1 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Isochorismatase PF00857.20 KOO25586.1 - 1.4e-26 93.8 0.6 2.2e-26 93.1 0.6 1.3 1 1 0 1 1 1 1 Isochorismatase family NAD_binding_11 PF14833.6 KOO25588.1 - 2e-35 121.7 0.1 3.1e-35 121.1 0.1 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 KOO25588.1 - 1e-24 87.5 0.1 1.7e-24 86.8 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Cpn10 PF00166.21 KOO25590.1 - 4.4e-14 52.3 0.0 9.9e-14 51.2 0.0 1.6 1 1 0 1 1 1 1 Chaperonin 10 Kd subunit WD40 PF00400.32 KOO25591.1 - 6.1e-14 52.2 14.5 0.00053 20.7 0.5 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO25591.1 - 3.3e-06 27.3 0.1 0.11 12.8 0.0 4.0 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WDCP PF15390.6 KOO25591.1 - 0.059 11.7 2.3 0.086 11.2 2.3 1.3 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family PQQ_3 PF13570.6 KOO25591.1 - 0.37 11.3 4.7 0.67 10.5 0.3 3.5 3 1 1 4 4 4 0 PQQ-like domain TUDOR_5 PF18359.1 KOO25592.1 - 0.0061 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 PHY PF00360.20 KOO25592.1 - 0.052 12.9 0.3 0.36 10.1 0.1 2.1 1 1 1 2 2 2 0 Phytochrome region DUF4537 PF15057.6 KOO25592.1 - 0.15 12.1 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) Tudor_3 PF18115.1 KOO25592.1 - 0.15 11.9 0.2 0.43 10.5 0.2 1.7 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain Glyco_hydro_42 PF02449.15 KOO25593.1 - 0.0001 21.8 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase MGTL PF17059.5 KOO25593.1 - 0.1 12.4 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 MgtA leader peptide KMP11 PF03037.16 KOO25593.1 - 0.18 12.6 0.1 0.36 11.6 0.1 1.4 1 0 0 1 1 1 0 Kinetoplastid membrane protein 11 CH PF00307.31 KOO25594.1 - 5.7e-15 55.4 0.0 1.5e-11 44.5 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain MIP PF00230.20 KOO25595.1 - 1.8e-44 152.2 78.3 8.8e-15 55.0 4.0 5.8 4 3 0 4 4 4 4 Major intrinsic protein Phtf-FEM1B_bdg PF12129.8 KOO25595.1 - 0.18 11.6 3.2 6 6.7 0.5 3.5 3 1 0 3 3 3 0 Male germ-cell putative homeodomain transcription factor Ank_2 PF12796.7 KOO25596.1 - 4.9e-27 94.3 1.8 2.8e-12 47.0 0.2 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO25596.1 - 1.1e-14 54.2 0.3 6.9e-07 29.4 0.0 4.2 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO25596.1 - 2.9e-12 46.5 0.7 3.4e-05 24.1 0.0 4.5 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 KOO25596.1 - 1.4e-11 44.6 0.0 2.7e-08 34.2 0.0 3.8 3 2 2 5 5 5 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO25596.1 - 2.1e-11 43.0 0.5 0.0003 21.0 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeat Peripla_BP_1 PF00532.21 KOO25596.1 - 0.075 12.4 0.3 0.11 11.8 0.3 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family DUF4200 PF13863.6 KOO25599.1 - 2e-37 128.2 26.4 2e-37 128.2 26.4 5.2 4 1 1 5 5 5 2 Domain of unknown function (DUF4200) Baculo_PEP_C PF04513.12 KOO25599.1 - 0.015 15.3 2.1 1.7 8.7 0.5 2.9 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_10 PF13374.6 KOO25600.1 - 1.7e-76 250.2 34.5 4e-13 48.8 0.2 8.3 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25600.1 - 2.5e-70 232.7 37.2 1.8e-18 66.6 1.7 7.2 2 1 4 7 7 7 6 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO25600.1 - 1.7e-23 83.6 13.4 4.4e-14 52.6 7.0 2.9 1 1 1 2 2 2 2 MalT-like TPR region TPR_1 PF00515.28 KOO25600.1 - 3.2e-21 74.2 8.5 0.0059 16.4 0.0 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25600.1 - 6.7e-21 72.7 4.8 0.022 15.0 0.0 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25600.1 - 1.5e-19 70.3 19.3 0.0009 19.8 0.1 7.5 1 1 5 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOO25600.1 - 4.7e-19 66.9 15.2 0.087 13.0 0.1 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_4 PF07721.14 KOO25600.1 - 2.7e-16 58.4 29.8 0.018 15.7 0.3 9.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25600.1 - 8.6e-14 50.8 5.1 0.91 10.0 0.0 6.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO25600.1 - 1.9e-11 44.3 23.7 0.01 16.3 1.3 5.3 4 1 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO25600.1 - 3.5e-11 42.3 24.2 0.064 13.3 0.1 6.8 7 0 0 7 7 7 5 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO25600.1 - 8.5e-11 41.9 6.7 1.8 8.8 0.0 6.9 7 0 0 7 7 7 3 Osmosensory transporter coiled coil TPR_11 PF13414.6 KOO25600.1 - 9.2e-08 31.6 11.8 0.72 9.6 0.2 7.1 7 0 0 7 7 7 1 TPR repeat TPR_14 PF13428.6 KOO25600.1 - 5e-07 30.0 33.8 3.2 8.8 0.2 8.1 8 0 0 8 8 8 3 Tetratricopeptide repeat HisKA_3 PF07730.13 KOO25600.1 - 5.8e-05 23.5 18.9 1.4 9.5 0.1 6.8 6 1 1 7 7 7 2 Histidine kinase BRCC36_C PF18110.1 KOO25600.1 - 0.0012 18.9 0.0 30 4.9 0.0 4.9 2 1 3 5 5 4 0 BRCC36 C-terminal helical domain DUF4145 PF13643.6 KOO25600.1 - 0.0037 17.4 2.1 8.7 6.5 0.0 4.4 1 1 4 5 5 5 0 Domain of unknown function (DUF4145) DUF2399 PF09664.10 KOO25600.1 - 0.0083 16.0 0.7 21 5.0 0.0 4.5 1 1 4 5 5 5 0 Protein of unknown function C-terminus (DUF2399) TPR_3 PF07720.12 KOO25600.1 - 0.032 14.2 0.0 52 4.0 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat ApoLp-III PF07464.11 KOO25600.1 - 0.26 11.4 0.0 94 3.1 0.0 3.8 2 1 0 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Calpain_inhib PF00748.19 KOO25600.1 - 1.7 9.1 5.1 98 3.4 0.0 4.4 5 0 0 5 5 5 0 Calpain inhibitor TPR_21 PF09976.9 KOO25600.1 - 6.4 6.4 8.6 97 2.6 0.4 4.6 1 1 1 3 3 3 0 Tetratricopeptide repeat-like domain Galactosyl_T PF01762.21 KOO25601.1 - 4.1e-09 36.5 0.0 1.7e-08 34.5 0.0 2.1 1 1 0 1 1 1 1 Galactosyltransferase Kelch_5 PF13854.6 KOO25603.1 - 1.2e-13 50.7 1.4 0.0088 16.0 0.0 6.0 6 0 0 6 6 6 3 Kelch motif EF-hand_1 PF00036.32 KOO25603.1 - 2.2e-13 48.7 0.2 0.0018 17.7 0.0 3.6 3 0 0 3 3 3 3 EF hand Kelch_3 PF13415.6 KOO25603.1 - 5e-11 42.6 4.8 0.01 16.1 0.0 5.7 5 0 0 5 5 5 2 Galactose oxidase, central domain EF-hand_7 PF13499.6 KOO25603.1 - 1e-10 41.9 0.0 5e-06 26.9 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair Nse4_C PF08743.10 KOO25603.1 - 1.6e-10 41.1 0.0 3.7e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Nse4 C-terminal EF-hand_5 PF13202.6 KOO25603.1 - 2.4e-10 39.4 0.4 0.0011 18.3 0.1 3.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO25603.1 - 3.8e-10 39.4 1.8 0.00059 19.6 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair Kelch_4 PF13418.6 KOO25603.1 - 6.9e-10 38.8 2.4 0.00096 19.1 0.0 5.4 4 1 1 5 5 5 2 Galactose oxidase, central domain EF-hand_6 PF13405.6 KOO25603.1 - 7.1e-10 38.0 0.1 0.011 15.6 0.0 3.9 3 0 0 3 3 3 2 EF-hand domain Kelch_6 PF13964.6 KOO25603.1 - 0.00077 19.7 0.0 42 4.6 0.0 4.9 5 0 0 5 5 4 0 Kelch motif LRR_4 PF12799.7 KOO25603.1 - 0.011 16.2 1.4 0.053 14.0 0.8 2.5 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO25603.1 - 0.019 14.7 1.4 0.029 14.1 0.1 1.9 2 0 0 2 2 2 0 Leucine rich repeat TIG PF01833.24 KOO25603.1 - 0.029 14.4 0.0 0.072 13.2 0.0 1.6 1 0 0 1 1 1 0 IPT/TIG domain Kelch_1 PF01344.25 KOO25603.1 - 0.048 13.3 1.6 28 4.4 0.0 4.3 5 0 0 5 5 5 0 Kelch motif Astro_capsid_N PF03115.14 KOO25603.1 - 0.086 11.5 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 Astrovirus capsid protein precursor PQ-loop PF04193.14 KOO25604.1 - 5e-07 29.4 1.0 1.4e-06 28.0 1.0 1.8 1 0 0 1 1 1 1 PQ loop repeat MtN3_slv PF03083.16 KOO25604.1 - 7.7e-06 25.9 3.5 1.6e-05 24.9 3.5 1.5 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange HECT PF00632.25 KOO25604.1 - 1.5e-05 24.7 0.0 2.4e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UQ_con PF00179.26 KOO25605.1 - 4.6e-13 49.0 0.0 6.4e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Birna_VP5 PF03042.14 KOO25606.1 - 0.057 13.5 0.1 0.083 12.9 0.1 1.2 1 0 0 1 1 1 0 Birnavirus VP5 protein PI31_Prot_C PF08577.11 KOO25606.1 - 0.098 13.8 0.1 0.23 12.6 0.1 1.9 1 1 0 1 1 1 0 PI31 proteasome regulator SAGA-Tad1 PF12767.7 KOO25607.1 - 6.4e-12 45.7 0.0 7.2e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit NIF PF03031.18 KOO25608.1 - 9.6e-39 132.6 0.1 1.4e-38 132.1 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase zf-HYPF PF07503.12 KOO25609.1 - 0.0014 18.3 14.0 3 7.7 0.2 4.9 4 0 0 4 4 4 4 HypF finger SIR2 PF02146.17 KOO25610.1 - 3.1e-26 92.4 0.0 3.7e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Sir2 family EF-hand_7 PF13499.6 KOO25611.1 - 1.8e-20 73.1 1.0 5.3e-09 36.4 0.9 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO25611.1 - 3.2e-20 70.1 6.0 0.00034 20.0 0.4 5.0 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO25611.1 - 1.5e-17 61.9 5.5 0.00027 20.6 0.0 5.8 5 0 0 5 5 5 4 EF-hand domain Pentapeptide_4 PF13599.6 KOO25611.1 - 4.1e-13 49.3 0.0 0.0028 17.8 0.0 6.2 5 1 0 6 6 6 2 Pentapeptide repeats (9 copies) EF-hand_5 PF13202.6 KOO25611.1 - 5.2e-10 38.4 4.9 0.11 12.0 0.0 5.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO25611.1 - 5.9e-08 32.4 6.1 0.0035 17.2 0.1 5.0 4 1 1 5 5 5 2 EF-hand domain pair SinI PF08671.10 KOO25611.1 - 0.0039 16.9 0.2 0.015 15.0 0.1 2.2 2 0 0 2 2 2 1 Anti-repressor SinI Caleosin PF05042.13 KOO25611.1 - 0.019 14.9 0.0 0.37 10.7 0.0 2.6 1 1 0 1 1 1 0 Caleosin related protein FliD_C PF07195.12 KOO25611.1 - 0.13 11.7 0.1 8.9 5.6 0.0 2.3 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Scm3 PF10384.9 KOO25611.1 - 0.14 11.9 0.1 14 5.5 0.0 2.8 2 0 0 2 2 2 0 Centromere protein Scm3 FliD_N PF02465.18 KOO25611.1 - 0.4 11.4 1.6 7.2 7.4 0.1 3.0 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus XK-related PF09815.9 KOO25611.1 - 8.5 5.3 10.1 72 2.3 10.0 2.0 1 1 0 1 1 1 0 XK-related protein EF-hand_1 PF00036.32 KOO25612.1 - 1.3e-25 87.0 2.2 5.1e-07 28.8 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO25612.1 - 4e-24 84.8 0.1 4.9e-14 52.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO25612.1 - 1.1e-23 81.1 1.0 1.1e-06 28.0 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO25612.1 - 1.5e-17 62.2 7.1 0.0001 21.6 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO25612.1 - 7.2e-16 57.8 5.1 5.5e-06 26.1 0.2 4.4 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 KOO25612.1 - 2.2e-05 24.3 0.1 0.24 11.4 0.0 2.9 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO25612.1 - 0.00076 19.8 0.0 0.27 11.6 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_11 PF08976.11 KOO25612.1 - 0.0016 19.3 0.0 0.027 15.3 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain Nitr_red_bet_C PF14711.6 KOO25612.1 - 0.22 11.2 2.9 0.72 9.6 2.9 2.0 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal zf-C2HC PF01530.18 KOO25613.1 - 0.0063 16.7 3.8 0.15 12.2 0.3 2.4 2 0 0 2 2 2 2 Zinc finger, C2HC type PRIMA1 PF16101.5 KOO25613.1 - 0.38 10.8 3.3 0.88 9.6 3.3 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 VIR_N PF15912.5 KOO25613.1 - 0.8 9.3 2.1 1.3 8.5 2.1 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal CAP_N PF01213.19 KOO25613.1 - 4 6.8 6.7 6.4 6.2 6.7 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SKG6 PF08693.10 KOO25613.1 - 4.2 6.9 8.7 8.9 5.8 8.7 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain G_path_suppress PF15991.5 KOO25614.1 - 0.0075 16.4 6.0 0.0075 16.4 6.0 3.1 2 1 1 3 3 3 1 G-protein pathway suppressor Cas_Csy4 PF09618.10 KOO25614.1 - 0.068 13.3 7.4 0.76 9.9 0.3 2.1 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) DUF572 PF04502.13 KOO25614.1 - 0.34 10.5 14.7 0.46 10.1 14.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) FAM76 PF16046.5 KOO25614.1 - 2.6 7.3 10.0 3.6 6.9 10.0 1.1 1 0 0 1 1 1 0 FAM76 protein SAPS PF04499.15 KOO25614.1 - 5.6 5.6 6.8 6.9 5.3 6.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1764 PF08576.10 KOO25614.1 - 9.4 7.2 10.3 31 5.5 0.3 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) TPR_10 PF13374.6 KOO25615.1 - 3.3e-22 77.6 0.6 1.1e-08 34.6 0.6 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25615.1 - 3.2e-21 75.4 9.6 4.5e-11 42.9 0.9 3.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25615.1 - 0.00073 19.3 0.1 0.55 10.1 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO25615.1 - 0.0012 18.8 0.5 0.23 11.6 0.0 3.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO25615.1 - 0.0018 17.7 3.9 0.0074 15.7 4.0 1.7 1 1 1 2 2 2 1 MalT-like TPR region TPR_7 PF13176.6 KOO25615.1 - 0.0023 17.8 1.2 0.28 11.3 0.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25615.1 - 0.0083 16.3 0.0 3.6 8.0 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25615.1 - 0.018 15.7 5.1 0.5 11.0 0.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25615.1 - 0.026 14.9 0.0 17 6.1 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO25615.1 - 0.16 12.8 7.0 11 7.1 0.2 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat APG6_N PF17675.1 KOO25616.1 - 0.022 15.3 8.1 0.029 14.9 8.1 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region YabA PF06156.13 KOO25616.1 - 0.25 12.0 4.4 0.4 11.3 4.4 1.2 1 0 0 1 1 1 0 Initiation control protein YabA DivIC PF04977.15 KOO25616.1 - 8.8 6.2 11.7 1.5 8.6 1.2 2.3 1 1 1 2 2 2 0 Septum formation initiator MMS19_N PF14500.6 KOO25617.1 - 1.3e-48 165.9 0.0 4.2e-47 160.9 0.0 3.0 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II UVR PF02151.19 KOO25617.1 - 0.0024 17.5 3.1 0.0048 16.6 3.1 1.5 1 0 0 1 1 1 1 UvrB/uvrC motif MMS19_C PF12460.8 KOO25617.1 - 0.074 12.2 0.0 2.8 7.0 0.0 2.4 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal EF-hand_7 PF13499.6 KOO25618.1 - 1.2e-22 80.1 0.0 4.2e-09 36.7 0.0 4.4 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 KOO25618.1 - 2.9e-22 76.5 1.3 0.00047 19.5 0.2 5.7 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 KOO25618.1 - 7.6e-19 66.0 1.2 0.0016 18.2 0.1 6.3 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 KOO25618.1 - 1e-13 50.0 1.4 0.0003 20.1 0.1 5.7 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO25618.1 - 6.2e-12 45.2 3.4 7.6e-05 22.5 0.0 5.6 4 2 1 5 5 5 3 EF-hand domain pair EF-hand_11 PF08976.11 KOO25618.1 - 0.0051 17.7 0.0 11 6.9 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain TerB PF05099.13 KOO25618.1 - 0.013 15.4 0.1 0.041 13.8 0.0 1.8 2 0 0 2 2 2 0 Tellurite resistance protein TerB B9-C2 PF07162.11 KOO25620.1 - 2.6e-30 105.8 0.0 4.1e-30 105.2 0.0 1.3 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Autoind_bind PF03472.15 KOO25620.1 - 0.078 12.5 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Autoinducer binding domain TPR_1 PF00515.28 KOO25622.1 - 2e-13 49.5 3.0 0.00013 21.6 0.0 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat HipN PF18253.1 KOO25622.1 - 9.4e-11 41.2 0.1 2.1e-10 40.1 0.0 1.7 2 0 0 2 2 2 1 Hsp70-interacting protein N N-terminal domain TPR_2 PF07719.17 KOO25622.1 - 9.7e-09 34.7 17.7 0.00057 19.8 1.0 5.0 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO25622.1 - 2.9e-07 30.5 0.7 0.002 18.3 0.0 2.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25622.1 - 3.4e-07 29.9 14.8 0.026 14.7 0.0 5.1 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO25622.1 - 3.9e-06 27.3 4.7 0.002 18.6 1.0 3.1 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25622.1 - 0.00033 20.8 1.1 0.0018 18.5 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO25622.1 - 0.00065 19.3 8.4 0.8 9.4 1.9 4.0 2 1 2 4 4 4 2 TPR repeat TPR_7 PF13176.6 KOO25622.1 - 0.00094 19.1 2.8 0.94 9.7 0.0 3.4 3 1 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO25622.1 - 0.0011 19.6 12.6 0.47 11.4 0.1 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25622.1 - 0.0014 19.3 14.5 0.0016 19.0 1.2 4.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25622.1 - 0.0022 18.2 0.1 0.0022 18.2 0.1 3.7 3 1 1 4 4 3 1 Tetratricopeptide repeat ALC PF17527.2 KOO25622.1 - 0.019 14.6 2.5 0.039 13.6 2.5 1.5 1 0 0 1 1 1 0 Phage ALC protein TPR_6 PF13174.6 KOO25622.1 - 0.026 15.1 14.6 4 8.3 0.0 5.3 4 2 0 4 4 4 0 Tetratricopeptide repeat Zip PF02535.22 KOO25622.1 - 0.14 11.4 9.7 0.21 10.7 9.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter NARP1 PF12569.8 KOO25622.1 - 2.4 7.0 24.5 0.027 13.4 10.5 2.9 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 DUF1538 PF07556.11 KOO25623.1 - 6.4e-96 319.7 32.1 4e-50 170.1 9.2 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF1538) C2 PF00168.30 KOO25624.1 - 1.2e-47 160.5 0.0 1.2e-16 60.9 0.0 3.5 3 0 0 3 3 3 3 C2 domain EF-hand_6 PF13405.6 KOO25624.1 - 7.8e-14 50.4 0.3 5.6e-05 22.8 0.0 4.0 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO25624.1 - 4.4e-12 46.3 0.0 2e-07 31.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO25624.1 - 1.5e-11 43.0 0.0 9e-05 21.8 0.0 3.8 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KOO25624.1 - 2.1e-09 36.5 0.7 0.019 14.5 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO25624.1 - 1.7e-06 27.8 0.0 0.15 11.9 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair RPGR1_C PF18111.1 KOO25624.1 - 0.0065 16.4 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Retinitis pigmentosa G-protein regulator interacting C-terminal Pkinase PF00069.25 KOO25625.1 - 7.9e-42 143.4 0.0 1.1e-41 142.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25625.1 - 1.1e-22 80.6 0.0 1.9e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PARP PF00644.20 KOO25625.1 - 1.3e-09 38.0 0.0 2e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF4470 PF14737.6 KOO25625.1 - 2.7e-09 37.1 0.0 6.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) TPR_1 PF00515.28 KOO25625.1 - 8.6e-07 28.5 9.0 0.00038 20.1 3.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat APH PF01636.23 KOO25625.1 - 4.3e-05 23.6 0.0 0.00022 21.3 0.0 2.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family CtsR_C PF17727.1 KOO25625.1 - 0.00013 22.0 0.1 0.59 10.3 0.0 3.0 1 1 2 3 3 3 2 CtsR C-terminal dimerization domain TPR_2 PF07719.17 KOO25625.1 - 0.00018 21.4 12.9 0.003 17.6 3.6 3.3 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25625.1 - 0.00071 19.6 3.9 0.01 16.0 0.8 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25625.1 - 0.00097 19.4 4.5 0.006 16.9 0.8 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat Kinase-like PF14531.6 KOO25625.1 - 0.0031 16.9 0.0 0.0055 16.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DUF2680 PF10925.8 KOO25625.1 - 0.0042 17.1 0.3 0.5 10.4 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF2680) Kdo PF06293.14 KOO25625.1 - 0.0055 16.1 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family NUDIX PF00293.28 KOO25625.1 - 0.0079 16.2 0.0 0.024 14.7 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain TPR_7 PF13176.6 KOO25625.1 - 0.12 12.4 0.2 0.72 10.0 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO25625.1 - 0.38 10.5 2.8 1.8 8.3 0.3 2.6 2 0 0 2 2 2 0 TPR repeat ERM PF00769.19 KOO25626.1 - 2.7 7.8 24.9 24 4.6 24.8 2.0 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Peptidase_M10 PF00413.24 KOO25627.1 - 0.00024 21.0 0.0 0.03 14.2 0.0 2.5 3 0 0 3 3 3 2 Matrixin EF-hand_5 PF13202.6 KOO25627.1 - 0.39 10.3 1.4 1.3 8.6 0.9 2.1 2 0 0 2 2 2 0 EF hand Metallopep PF12044.8 KOO25627.1 - 3.7 6.0 5.8 0.22 10.1 0.6 1.5 2 0 0 2 2 2 0 Putative peptidase family Peripla_BP_6 PF13458.6 KOO25629.1 - 6.2e-05 22.8 0.3 0.00011 22.0 0.3 1.3 1 0 0 1 1 1 1 Periplasmic binding protein EGF_2 PF07974.13 KOO25629.1 - 0.00012 22.3 10.5 0.00029 21.1 10.5 1.6 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 KOO25629.1 - 0.11 13.2 6.1 0.28 11.9 6.1 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF Laminin_EGF PF00053.24 KOO25629.1 - 0.32 11.2 8.5 0.058 13.6 4.1 2.0 2 0 0 2 2 2 0 Laminin EGF domain EGF PF00008.27 KOO25629.1 - 0.81 10.1 10.4 0.039 14.3 4.6 1.8 2 0 0 2 2 2 0 EGF-like domain EB PF01683.18 KOO25629.1 - 4.7 7.6 11.1 1.4 9.2 6.6 2.1 2 0 0 2 2 2 0 EB module Lactamase_B_2 PF12706.7 KOO25630.1 - 2.3e-08 33.8 4.9 4.3e-06 26.4 4.9 2.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KOO25630.1 - 3e-05 24.1 0.1 5.3e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Creatininase PF02633.14 KOO25630.1 - 0.0056 16.2 0.0 0.0098 15.4 0.0 1.4 1 0 0 1 1 1 1 Creatinine amidohydrolase TMF_TATA_bd PF12325.8 KOO25631.1 - 0.0025 18.0 5.4 0.0025 18.0 5.4 6.8 3 1 3 6 6 6 1 TATA element modulatory factor 1 TATA binding ZapB PF06005.12 KOO25631.1 - 0.019 15.4 3.3 0.019 15.4 3.3 7.3 5 2 2 7 7 7 0 Cell division protein ZapB RA PF00788.23 KOO25631.1 - 0.11 13.2 0.7 0.27 11.9 0.7 1.6 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain Osmo_CC PF08946.10 KOO25631.1 - 0.13 12.5 4.0 0.21 11.8 0.3 3.3 3 0 0 3 3 3 0 Osmosensory transporter coiled coil Atg14 PF10186.9 KOO25631.1 - 0.2 10.7 27.7 0.2 10.7 5.5 3.3 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sec34 PF04136.15 KOO25631.1 - 0.31 10.9 14.2 2.5 8.0 5.3 3.3 2 1 0 2 2 2 0 Sec34-like family ATG_C PF09333.11 KOO25631.1 - 0.47 10.8 3.8 1.8 8.9 0.1 3.2 3 0 0 3 3 3 0 Autophagy-related protein C terminal domain Spore_IV_A PF09547.10 KOO25631.1 - 4.8 6.0 9.7 0.65 8.9 1.7 2.3 1 1 1 2 2 2 0 Stage IV sporulation protein A (spore_IV_A) DUF4686 PF15742.5 KOO25631.1 - 5.2 6.1 46.7 0.25 10.4 7.0 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4686) TPR_MLP1_2 PF07926.12 KOO25631.1 - 8.4 6.5 65.6 0.29 11.2 13.5 6.8 3 2 3 6 6 6 0 TPR/MLP1/MLP2-like protein PAS_4 PF08448.10 KOO25632.1 - 3.7e-23 81.9 0.3 2.2e-14 53.7 0.1 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 KOO25632.1 - 1.1e-21 76.9 0.1 2e-17 63.2 0.1 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 KOO25632.1 - 8.1e-21 74.2 0.0 5.8e-13 49.0 0.0 2.2 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 KOO25632.1 - 1.6e-15 57.2 0.0 2e-06 28.0 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 KOO25632.1 - 8e-06 25.8 0.0 6.4e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS_10 PF13596.6 KOO25632.1 - 0.0034 17.9 0.0 0.013 16.1 0.0 1.9 2 0 0 2 2 2 1 PAS domain Pkinase PF00069.25 KOO25634.1 - 0.29 10.5 0.0 0.36 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Sec7 PF01369.20 KOO25635.1 - 2.5e-67 226.1 0.0 3.5e-67 225.6 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain Fer2_4 PF13510.6 KOO25636.1 - 9.7e-11 41.6 0.4 1.4e-09 37.9 0.3 2.2 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain PDZ PF00595.24 KOO25636.1 - 3e-08 33.9 0.5 7.2e-08 32.7 0.2 1.8 2 0 0 2 2 2 1 PDZ domain Fer2 PF00111.27 KOO25636.1 - 3.8e-07 30.0 1.8 1.1e-06 28.5 1.8 1.8 1 1 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain PDZ_2 PF13180.6 KOO25636.1 - 0.0021 18.3 0.4 0.0074 16.6 0.1 2.0 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KOO25636.1 - 0.0028 17.4 0.9 0.0072 16.1 0.9 1.8 1 0 0 1 1 1 1 PDZ domain Atx10homo_assoc PF09759.9 KOO25637.1 - 4.6e-09 36.2 1.8 0.026 14.5 0.0 5.9 5 2 1 6 6 6 4 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.7 KOO25637.1 - 5e-05 23.4 0.8 0.15 12.1 0.1 2.6 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 KOO25637.1 - 0.056 13.5 24.6 0.9 9.7 0.1 8.7 10 0 0 10 10 10 0 Armadillo/beta-catenin-like repeat DUF3510 PF12022.8 KOO25638.1 - 0.032 14.6 0.0 0.034 14.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) CBM_14 PF01607.24 KOO25638.1 - 0.039 14.1 0.4 0.069 13.3 0.4 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain FAM91_C PF14648.6 KOO25639.1 - 5.8e-88 295.6 0.0 5.9e-87 292.3 0.0 2.1 1 1 0 1 1 1 1 FAM91 C-terminus FAM91_N PF14647.6 KOO25639.1 - 5.2e-68 229.6 0.0 1.3e-66 225.0 0.0 2.4 2 1 0 2 2 2 1 FAM91 N-terminus Mito_carr PF00153.27 KOO25640.1 - 1.1e-35 121.4 4.8 2.2e-15 56.3 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein PRP3 PF08572.10 KOO25640.1 - 0.44 10.2 10.7 0.052 13.3 3.8 2.2 1 1 1 2 2 2 0 pre-mRNA processing factor 3 (PRP3) Ndc1_Nup PF09531.10 KOO25640.1 - 2.6 6.6 4.1 3.1 6.4 4.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RNA_polI_A34 PF08208.11 KOO25640.1 - 5.5 7.0 16.5 10 6.1 16.5 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 TFIIA PF03153.13 KOO25641.1 - 1.5 8.8 23.6 1.7 8.5 23.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PITH PF06201.13 KOO25642.1 - 7.2e-34 117.2 0.0 8.3e-34 117.0 0.0 1.0 1 0 0 1 1 1 1 PITH domain ANAPC10 PF03256.16 KOO25642.1 - 0.039 13.6 0.0 0.072 12.7 0.0 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) Hydrolase_4 PF12146.8 KOO25643.1 - 0.0062 15.8 0.1 0.46 9.7 0.0 2.0 1 1 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 KOO25643.1 - 0.026 14.1 0.0 0.029 13.9 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family ATP-synt_C PF00137.21 KOO25644.1 - 7.8e-28 96.6 24.3 1.2e-14 54.4 8.3 2.4 2 0 0 2 2 2 2 ATP synthase subunit C zf-RING_UBOX PF13445.6 KOO25644.1 - 9.2e-06 25.6 0.7 2.4e-05 24.2 0.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KOO25644.1 - 1.3e-05 25.4 4.2 1.3e-05 25.4 4.2 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 KOO25644.1 - 1.4e-05 24.9 1.6 1.4e-05 24.9 1.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO25644.1 - 0.00046 20.0 2.9 0.00046 20.0 2.9 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 KOO25644.1 - 0.0023 17.9 0.2 0.004 17.1 0.2 1.3 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_5 PF14634.6 KOO25644.1 - 0.0068 16.3 1.8 0.0068 16.3 1.8 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOO25644.1 - 0.011 15.6 2.4 0.011 15.6 2.4 2.3 3 1 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOO25644.1 - 0.015 15.4 1.4 0.015 15.4 1.4 2.0 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 KOO25644.1 - 0.085 12.7 2.8 0.21 11.4 2.8 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 KOO25644.1 - 0.19 11.9 1.9 0.47 10.6 1.9 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 KOO25644.1 - 0.31 10.9 11.8 0.26 11.2 5.0 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 DUF3842 PF12953.7 KOO25645.1 - 0.42 11.0 4.3 0.57 10.6 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) TPH PF13868.6 KOO25646.1 - 2.8e-19 68.8 111.5 2.8e-19 68.8 111.5 2.1 1 1 1 2 2 2 2 Trichohyalin-plectin-homology domain Pkinase PF00069.25 KOO25648.1 - 2.1e-62 210.9 0.0 3.1e-62 210.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO25648.1 - 1.1e-40 137.6 1.0 6.2e-13 48.6 0.0 3.8 3 1 0 3 3 3 3 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO25648.1 - 4.6e-26 91.7 0.0 8.1e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO25648.1 - 0.042 13.8 0.0 0.28 11.1 0.0 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO25648.1 - 0.059 12.7 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 KOO25648.1 - 0.11 11.8 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KOO25648.1 - 0.13 11.3 0.0 0.28 10.2 0.0 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.25 KOO25649.1 - 1.2e-45 156.0 0.0 1.5e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25649.1 - 9e-23 80.9 0.0 1.3e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO25649.1 - 2.6e-06 27.0 0.2 0.0014 18.0 0.1 2.7 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.14 KOO25649.1 - 3.9e-05 23.1 0.0 6.3e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family IQ PF00612.27 KOO25649.1 - 0.0026 17.4 0.2 0.0051 16.5 0.2 1.5 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF5437 PF17505.2 KOO25649.1 - 0.19 11.8 1.0 0.67 10.0 1.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5437) HAD PF12710.7 KOO25651.1 - 9e-19 68.6 0.0 1.1e-18 68.3 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Metallophos PF00149.28 KOO25652.1 - 1.9e-38 133.0 0.3 2.6e-38 132.6 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOO25652.1 - 0.00046 20.6 0.3 0.00094 19.6 0.3 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Fer4_12 PF13353.6 KOO25652.1 - 0.07 13.4 0.0 3 8.1 0.0 2.2 2 0 0 2 2 2 0 4Fe-4S single cluster domain Arm PF00514.23 KOO25653.1 - 4.4e-16 58.3 18.1 1.5e-06 28.0 0.4 4.2 4 0 0 4 4 4 4 Armadillo/beta-catenin-like repeat TRL PF13146.6 KOO25653.1 - 0.38 11.1 9.3 0.98 9.7 0.4 3.0 2 1 1 3 3 3 0 TRL-like protein family ACTH_assoc PF16102.5 KOO25653.1 - 1.1 10.2 0.1 1.1 10.2 0.1 3.8 4 1 0 4 4 4 0 ACTH-associated domain HEAT PF02985.22 KOO25653.1 - 1.1 9.7 8.0 55 4.4 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat PABP PF00658.18 KOO25654.1 - 1.8e-26 92.1 0.2 2.1e-26 91.8 0.2 1.1 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain BLUF PF04940.12 KOO25654.1 - 0.03 14.4 0.0 0.034 14.3 0.0 1.2 1 0 0 1 1 1 0 Sensors of blue-light using FAD Pkinase PF00069.25 KOO25655.1 - 4.3e-67 226.2 0.0 5.5e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25655.1 - 6.3e-33 114.1 0.1 9.3e-32 110.3 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO25655.1 - 3.8e-06 26.1 0.6 6e-06 25.4 0.6 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KOO25655.1 - 0.00021 20.7 0.0 0.0012 18.3 0.0 2.0 2 1 1 3 3 3 1 Kinase-like APH PF01636.23 KOO25655.1 - 0.0088 16.0 2.1 0.041 13.8 0.3 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family MDMPI_N PF11716.8 KOO25656.1 - 0.016 15.9 5.0 0.032 14.9 5.0 1.7 1 1 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain Methyltransf_11 PF08241.12 KOO25657.1 - 1.5e-09 38.4 0.0 2.8e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO25657.1 - 3.6e-07 30.8 0.0 2.8e-06 27.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO25657.1 - 4.7e-07 29.7 0.0 0.0012 18.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_29 PF03141.16 KOO25657.1 - 6.2e-07 28.4 0.0 8e-07 28.0 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_23 PF13489.6 KOO25657.1 - 6.1e-06 26.2 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO25657.1 - 0.0051 17.5 0.0 0.034 14.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO25657.1 - 0.013 14.8 0.0 0.11 11.8 0.0 2.3 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 KOO25657.1 - 0.03 14.2 0.0 5.9 6.7 0.0 2.1 2 0 0 2 2 2 0 Hypothetical methyltransferase MTS PF05175.14 KOO25657.1 - 0.062 12.9 0.0 0.16 11.5 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Toxin_18 PF08087.11 KOO25657.1 - 9.7 6.3 6.5 1.6e+02 2.4 2.6 3.1 1 1 2 3 3 3 0 Conotoxin O-superfamily HAD_2 PF13419.6 KOO25658.1 - 2e-06 28.0 0.0 1.4e-05 25.3 0.0 2.2 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Dynamitin PF04912.14 KOO25658.1 - 0.01 15.2 0.1 0.01 15.2 0.1 2.8 2 1 1 3 3 3 0 Dynamitin Redoxin PF08534.10 KOO25659.1 - 1.6e-09 37.6 0.0 2.2e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin adh_short PF00106.25 KOO25661.1 - 1.2e-47 162.0 0.1 1.6e-47 161.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO25661.1 - 1.9e-27 96.4 0.1 2.4e-27 96.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO25661.1 - 5.9e-08 32.8 0.1 9.8e-08 32.1 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOO25661.1 - 0.0025 17.3 1.7 0.098 12.1 1.7 2.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 KOO25661.1 - 0.011 16.0 0.2 0.089 13.1 0.1 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 KOO25661.1 - 0.027 14.1 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA THF_DHG_CYH_C PF02882.19 KOO25661.1 - 0.051 12.9 0.2 0.24 10.7 0.0 2.2 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.6 KOO25661.1 - 0.055 13.4 0.1 0.12 12.3 0.1 1.4 1 1 0 1 1 1 0 NAD(P)H-binding 3HCDH_N PF02737.18 KOO25661.1 - 0.093 12.6 0.3 0.15 11.9 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_16 PF10294.9 KOO25662.1 - 1.4e-23 83.5 0.0 2.2e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 KOO25662.1 - 0.0061 16.1 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 KOO25662.1 - 0.016 14.9 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 KOO25662.1 - 0.04 13.8 0.0 0.061 13.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 KOO25662.1 - 0.066 13.9 0.0 0.15 12.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 KOO25662.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) adh_short_C2 PF13561.6 KOO25663.1 - 3e-39 135.0 0.2 3.5e-39 134.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO25663.1 - 8.4e-19 67.8 0.1 1.1e-18 67.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase DEAD PF00270.29 KOO25664.1 - 2e-09 37.5 0.0 7.1e-09 35.7 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO25664.1 - 3.5e-05 24.1 0.0 6.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Arm PF00514.23 KOO25665.1 - 5.5e-27 92.9 6.5 3.5e-08 33.2 0.2 4.5 4 0 0 4 4 4 4 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 KOO25665.1 - 0.0017 17.8 0.0 0.25 10.8 0.0 2.6 1 1 2 3 3 3 3 Armadillo-like Atx10homo_assoc PF09759.9 KOO25665.1 - 0.0054 16.7 0.0 0.21 11.6 0.0 2.5 1 1 2 3 3 3 2 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 KOO25667.1 - 9.6e-53 174.7 67.4 1.6e-05 24.8 0.1 18.2 19 0 0 19 19 19 13 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO25667.1 - 1.8e-13 50.6 47.2 0.014 15.8 0.2 11.6 5 3 4 11 11 11 7 HEAT repeats HEAT_EZ PF13513.6 KOO25667.1 - 7.4e-10 39.1 49.1 0.0086 16.6 0.0 12.2 14 0 0 14 14 14 5 HEAT-like repeat Adaptin_N PF01602.20 KOO25667.1 - 1.3e-08 33.9 6.1 2.4e-05 23.1 1.3 4.1 3 1 0 3 3 3 2 Adaptin N terminal region HEAT PF02985.22 KOO25667.1 - 4.1e-08 32.8 21.3 0.52 10.7 0.2 9.7 8 0 0 8 8 8 2 HEAT repeat V-ATPase_H_C PF11698.8 KOO25667.1 - 0.0014 18.7 3.8 0.27 11.4 0.0 5.4 5 1 3 8 8 8 2 V-ATPase subunit H Arm_2 PF04826.13 KOO25667.1 - 0.0026 17.3 1.7 24 4.3 0.1 5.3 4 2 3 7 7 7 0 Armadillo-like Cnd1 PF12717.7 KOO25667.1 - 0.0081 16.2 1.2 24 4.9 0.0 4.8 3 2 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 RICTOR_N PF14664.6 KOO25667.1 - 0.076 12.0 2.8 2 7.3 0.0 4.2 5 1 0 5 5 5 0 Rapamycin-insensitive companion of mTOR, N-term DUF383 PF04063.14 KOO25667.1 - 0.09 12.4 0.1 6.3 6.4 0.0 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF383) WAPL PF07814.13 KOO25667.1 - 0.17 10.6 9.2 6.4 5.5 0.1 4.6 2 2 1 4 4 4 0 Wings apart-like protein regulation of heterochromatin E3_UbLigase_R4 PF13764.6 KOO25667.1 - 0.26 9.4 3.9 0.11 10.6 0.1 2.2 3 0 0 3 3 3 0 E3 ubiquitin-protein ligase UBR4 IFRD PF05004.13 KOO25667.1 - 2.4 7.2 12.7 1.8 7.6 0.0 5.2 5 2 2 7 7 7 0 Interferon-related developmental regulator (IFRD) DUF659 PF04937.15 KOO25668.1 - 0.00013 21.9 0.0 0.00013 21.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) SIS PF01380.22 KOO25669.1 - 6.6e-58 194.2 0.1 8e-31 106.6 0.0 3.2 3 0 0 3 3 3 2 SIS domain GATase_6 PF13522.6 KOO25669.1 - 3.9e-22 78.9 0.1 8.1e-22 77.9 0.1 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KOO25669.1 - 2.1e-14 53.5 0.0 4e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 KOO25669.1 - 0.0025 17.9 0.0 0.0085 16.1 0.0 2.0 1 0 0 1 1 1 1 SIS domain GATase_4 PF13230.6 KOO25669.1 - 0.0079 15.1 0.1 0.015 14.2 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II PDZ_6 PF17820.1 KOO25670.1 - 3.5e-07 30.0 0.2 5.9e-07 29.2 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO25670.1 - 3.4e-05 24.1 0.1 7.1e-05 23.0 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO25670.1 - 3.4e-05 24.1 0.5 6.3e-05 23.3 0.5 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KOO25670.1 - 0.046 13.7 0.1 0.08 12.9 0.1 1.5 1 0 0 1 1 1 0 Tricorn protease PDZ domain LRR_8 PF13855.6 KOO25671.1 - 5.1e-28 96.6 23.4 8e-08 31.9 2.1 5.6 3 1 1 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KOO25671.1 - 4.7e-21 74.5 29.6 1.3e-05 25.4 0.4 6.9 3 1 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO25671.1 - 7.6e-10 38.0 24.1 3.7 8.5 0.0 10.0 9 1 0 9 9 9 5 Leucine Rich Repeat LRR_9 PF14580.6 KOO25671.1 - 0.0069 15.9 3.0 1.9 7.9 0.2 2.9 2 1 0 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 KOO25671.1 - 0.026 14.5 26.8 2.1 8.6 0.4 8.2 9 0 0 9 9 9 0 Leucine Rich repeat MSP PF01716.18 KOO25672.1 - 9.7e-89 296.7 0.2 1.2e-88 296.4 0.2 1.1 1 0 0 1 1 1 1 Manganese-stabilising protein / photosystem II polypeptide HLH PF00010.26 KOO25673.1 - 8.1e-11 41.7 0.1 1.6e-10 40.8 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2075 PF09848.9 KOO25673.1 - 0.24 10.6 0.1 0.31 10.2 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SEP PF08059.13 KOO25674.1 - 3.4e-09 37.1 0.0 6.9e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 KOO25674.1 - 0.00023 21.3 0.0 0.00059 20.0 0.0 1.7 1 0 0 1 1 1 1 UBX domain DivIC PF04977.15 KOO25674.1 - 0.021 14.6 0.1 0.037 13.8 0.1 1.3 1 0 0 1 1 1 0 Septum formation initiator ZapB PF06005.12 KOO25674.1 - 0.088 13.3 0.2 0.17 12.4 0.2 1.3 1 0 0 1 1 1 0 Cell division protein ZapB CASP_C PF08172.12 KOO25674.1 - 0.13 11.6 0.1 0.21 10.9 0.1 1.2 1 0 0 1 1 1 0 CASP C terminal GIT_CC PF16559.5 KOO25674.1 - 0.4 10.6 2.1 0.77 9.7 2.1 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Serglycin PF04360.12 KOO25674.1 - 0.82 9.6 3.6 3.9 7.4 0.8 2.4 2 0 0 2 2 2 0 Serglycin VSG_B PF13206.6 KOO25675.1 - 0.64 9.2 8.1 0.96 8.6 8.1 1.2 1 0 0 1 1 1 0 Trypanosomal VSG domain EF-hand_5 PF13202.6 KOO25676.1 - 1.1e-13 49.9 13.1 0.0032 16.9 0.0 6.0 5 1 2 7 7 7 5 EF hand EF-hand_1 PF00036.32 KOO25676.1 - 1.7e-12 45.9 10.5 0.058 13.0 0.2 6.6 4 1 3 7 7 7 5 EF hand EF-hand_6 PF13405.6 KOO25676.1 - 3.4e-10 39.0 11.0 0.51 10.4 0.1 6.1 4 1 3 7 7 7 5 EF-hand domain EF-hand_7 PF13499.6 KOO25676.1 - 3.3e-07 30.7 6.0 0.19 12.2 1.7 4.9 2 1 3 5 5 5 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO25676.1 - 7.5e-05 22.5 2.3 2.2 8.2 0.0 4.9 3 1 3 6 6 6 2 EF-hand domain pair Dockerin_1 PF00404.18 KOO25676.1 - 0.00053 20.1 12.4 0.33 11.2 0.2 4.7 2 1 3 5 5 5 3 Dockerin type I domain PRIMA1 PF16101.5 KOO25676.1 - 0.062 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 FG-GAP PF01839.23 KOO25676.1 - 0.14 12.3 5.6 23 5.2 0.0 4.7 5 0 0 5 5 5 0 FG-GAP repeat DUF3194 PF11419.8 KOO25676.1 - 1.9 8.9 5.8 24 5.4 6.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3194) zf-GRF PF06839.12 KOO25677.1 - 1.2e-12 47.7 1.9 2.4e-12 46.8 1.9 1.5 1 0 0 1 1 1 1 GRF zinc finger Zn_clus PF00172.18 KOO25678.1 - 2.1e-12 47.0 23.2 6.4e-07 29.4 10.4 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Sde2_N_Ubi PF13019.6 KOO25679.1 - 6e-12 45.7 4.9 6.5e-12 45.6 4.9 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain DUF3775 PF12616.8 KOO25679.1 - 0.17 11.9 0.2 0.17 11.9 0.2 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3775) Peptidase_M14 PF00246.24 KOO25680.1 - 5.5e-17 62.5 0.0 8e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 KOO25680.1 - 4.8e-05 22.6 0.1 9.2e-05 21.7 0.1 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Kin17_mid PF10357.9 KOO25681.1 - 1e-41 141.8 4.9 1.5e-41 141.2 4.9 1.2 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 KOO25681.1 - 3.6e-15 55.8 0.2 2.2e-14 53.3 0.4 2.0 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain zf-met PF12874.7 KOO25681.1 - 0.0068 16.8 6.3 0.017 15.5 6.3 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOO25681.1 - 0.05 13.9 4.5 0.1 12.9 4.5 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Ribosomal_S18 PF01084.20 KOO25681.1 - 0.064 13.5 0.5 0.3 11.3 0.3 2.2 2 0 0 2 2 2 0 Ribosomal protein S18 zf-C2H2_2 PF12756.7 KOO25681.1 - 0.29 11.5 7.2 0.28 11.5 3.2 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) UIM PF02809.20 KOO25682.1 - 0.012 15.4 8.4 0.64 10.1 0.2 3.3 3 0 0 3 3 3 0 Ubiquitin interaction motif Peptidase_M10 PF00413.24 KOO25682.1 - 0.016 15.1 0.1 3.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Matrixin aGPT-Pplase1 PF18723.1 KOO25683.1 - 0.023 14.1 0.0 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 1 PARP PF00644.20 KOO25684.1 - 3.5e-14 52.8 0.0 7.4e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain MFS_1 PF07690.16 KOO25685.1 - 7.5e-18 64.6 42.5 6.2e-09 35.2 9.2 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO25685.1 - 4.3e-06 25.9 1.3 0.00037 19.5 0.0 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter LacY_symp PF01306.19 KOO25685.1 - 2.4 6.8 11.1 2.5 6.8 0.2 2.5 2 1 0 2 2 2 0 LacY proton/sugar symporter Glyco_transf_90 PF05686.12 KOO25686.1 - 1.8e-41 142.4 0.0 3e-41 141.6 0.0 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 90 Complex1_LYR PF05347.15 KOO25686.1 - 1.4e-05 25.1 1.6 3e-05 24.0 0.2 2.4 2 1 0 2 2 2 1 Complex 1 protein (LYR family) Glyco_trans_1_2 PF13524.6 KOO25686.1 - 0.047 14.1 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 Pkinase PF00069.25 KOO25687.1 - 2.1e-19 69.9 0.0 3.2e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25687.1 - 1.1e-08 34.7 0.0 1.5e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO25687.1 - 0.0085 16.0 3.0 0.014 15.3 0.2 2.4 3 0 0 3 3 3 1 Phosphotransferase enzyme family EF-hand_7 PF13499.6 KOO25689.1 - 1.2e-33 115.4 15.6 5.4e-11 42.8 0.9 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO25689.1 - 3e-33 110.9 22.0 5.9e-06 25.5 0.3 6.4 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO25689.1 - 1.4e-32 108.8 19.7 3.1e-05 23.6 0.1 6.5 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.6 KOO25689.1 - 4.6e-23 80.8 17.0 1.3e-09 37.8 0.3 5.6 3 2 3 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO25689.1 - 5.9e-20 69.8 26.0 5.8e-06 25.6 0.4 6.0 6 0 0 6 6 6 5 EF hand EF-hand_9 PF14658.6 KOO25689.1 - 3.2e-05 24.2 0.2 2.7 8.4 0.0 4.0 3 1 2 5 5 5 2 EF-hand domain EF-hand_11 PF08976.11 KOO25689.1 - 0.00086 20.2 0.0 1.1 10.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO25689.1 - 0.0019 18.5 3.8 1.7 9.0 0.6 4.0 3 2 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO25689.1 - 0.0094 15.8 11.2 11 6.0 0.1 5.9 5 1 1 6 6 6 1 EF hand p25-alpha PF05517.12 KOO25689.1 - 0.011 15.9 0.0 0.12 12.5 0.0 2.4 2 0 0 2 2 2 0 p25-alpha EF-hand_14 PF17959.1 KOO25689.1 - 0.03 14.7 0.6 2.9 8.3 0.0 3.6 3 1 1 4 4 4 0 EF-hand domain Caleosin PF05042.13 KOO25689.1 - 0.13 12.2 2.2 57 3.6 0.0 4.1 3 2 2 5 5 5 0 Caleosin related protein TMEM144 PF07857.12 KOO25691.1 - 0.065 12.2 14.6 0.38 9.7 0.9 3.9 2 1 2 4 4 4 0 Transmembrane family, TMEM144 of transporters HAP2-GCS1 PF10699.9 KOO25691.1 - 0.15 12.0 6.6 19 5.4 0.0 4.8 5 0 0 5 5 5 0 Male gamete fusion factor Trypan_glycop_C PF10659.9 KOO25691.1 - 0.21 12.0 1.2 0.41 11.0 1.2 1.4 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain Synaptobrevin PF00957.21 KOO25692.1 - 3.9e-20 71.4 0.0 5.8e-20 70.9 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 KOO25692.1 - 0.034 14.2 0.0 0.067 13.2 0.0 1.5 1 0 0 1 1 1 0 Regulated-SNARE-like domain Transcrip_reg PF01709.20 KOO25693.1 - 1.8e-41 142.1 0.1 2.2e-41 141.9 0.1 1.0 1 0 0 1 1 1 1 Transcriptional regulator DUF2569 PF10754.9 KOO25694.1 - 0.033 14.6 0.1 0.033 14.6 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) Atg14 PF10186.9 KOO25695.1 - 0.003 16.7 14.0 0.0036 16.4 14.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Perilipin PF03036.16 KOO25695.1 - 0.007 15.4 12.0 0.0086 15.1 12.0 1.2 1 0 0 1 1 1 1 Perilipin family OmpH PF03938.14 KOO25695.1 - 0.009 16.4 22.6 0.009 16.4 22.6 2.1 1 1 1 2 2 2 1 Outer membrane protein (OmpH-like) ADIP PF11559.8 KOO25695.1 - 0.073 13.2 25.6 0.045 13.8 15.3 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Glyco_hydro_38 PF18438.1 KOO25695.1 - 0.15 12.2 3.3 0.18 11.9 2.2 1.7 1 1 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal domain 1 SASP PF00269.20 KOO25695.1 - 0.18 11.8 5.2 1 9.4 5.2 2.3 1 1 0 1 1 1 0 Small, acid-soluble spore proteins, alpha/beta type FliJ PF02050.16 KOO25695.1 - 0.18 12.0 27.2 1.4 9.2 26.4 2.5 1 1 1 2 2 2 0 Flagellar FliJ protein DUF2011 PF09428.10 KOO25695.1 - 0.2 11.9 2.7 0.11 12.7 0.5 1.8 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2011) AATF-Che1 PF13339.6 KOO25695.1 - 0.33 11.6 12.5 0.26 12.0 11.4 1.4 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF1515 PF07439.11 KOO25695.1 - 0.37 10.9 5.4 0.64 10.1 5.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) Spc7 PF08317.11 KOO25695.1 - 0.51 9.2 28.6 1.5 7.6 29.0 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein YlbE PF14003.6 KOO25695.1 - 0.53 10.8 6.0 1.8 9.0 0.5 2.7 2 1 0 2 2 2 0 YlbE-like protein DUF1664 PF07889.12 KOO25695.1 - 0.57 10.2 16.8 3 7.9 8.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CorA PF01544.18 KOO25695.1 - 0.61 9.4 14.9 0.19 11.0 11.4 1.7 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF4407 PF14362.6 KOO25695.1 - 0.65 9.3 19.5 0.36 10.1 1.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Prominin PF05478.11 KOO25695.1 - 1.1 7.2 8.9 1.3 6.9 8.9 1.1 1 0 0 1 1 1 0 Prominin Sulfatase_C PF14707.6 KOO25695.1 - 1.1 10.0 5.7 0.97 10.2 2.6 2.2 1 1 2 3 3 3 0 C-terminal region of aryl-sulfatase CHASE7 PF17151.4 KOO25695.1 - 1.2 8.7 7.9 1.2 8.8 0.3 2.4 1 1 0 2 2 2 0 Periplasmic sensor domain Baculo_PEP_C PF04513.12 KOO25695.1 - 1.7 8.7 6.1 7.3 6.6 2.5 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 KOO25695.1 - 3.5 7.9 10.0 6.4 7.1 0.2 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) LMBR1 PF04791.16 KOO25695.1 - 3.6 6.4 10.8 4.6 6.0 10.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 KOO25695.1 - 4 6.9 18.2 18 4.8 18.2 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit HMMR_N PF15905.5 KOO25695.1 - 4.9 6.5 27.6 6.8 6.1 27.6 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF848 PF05852.11 KOO25695.1 - 6.2 6.9 18.8 0.71 10.0 11.6 2.4 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) FlpD PF02662.16 KOO25695.1 - 8.1 6.5 7.2 7.9 6.5 1.9 2.4 2 1 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit zf-C3HC4_3 PF13920.6 KOO25698.1 - 0.37 10.7 9.8 0.67 9.9 7.1 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO25698.1 - 5.6 6.9 12.0 1.5 8.8 8.0 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FGE-sulfatase PF03781.16 KOO25699.1 - 1.4e-24 87.1 4.1 3.4e-24 85.8 4.1 1.7 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Methyltransf_25 PF13649.6 KOO25699.1 - 1e-12 48.6 0.0 4.4e-10 40.1 0.0 2.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO25699.1 - 6.6e-12 45.9 0.0 6.8e-11 42.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO25699.1 - 5.2e-11 42.6 0.0 1.1e-05 25.3 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 KOO25699.1 - 2e-08 34.2 0.0 4.2e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO25699.1 - 3.7e-08 34.0 0.0 2.3e-07 31.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain DinB_2 PF12867.7 KOO25699.1 - 2.7e-05 24.7 2.8 4.9e-05 23.8 2.3 1.8 1 1 0 1 1 1 1 DinB superfamily Ubie_methyltran PF01209.18 KOO25699.1 - 0.011 15.0 0.0 5.2 6.3 0.0 2.3 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 KOO25699.1 - 0.044 13.4 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase TPMT PF05724.11 KOO25699.1 - 0.051 13.2 0.0 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NodS PF05401.11 KOO25699.1 - 0.079 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_4 PF02390.17 KOO25699.1 - 0.093 12.2 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_32 PF13679.6 KOO25699.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TPR_12 PF13424.6 KOO25700.1 - 1.5e-36 124.6 32.0 2.9e-11 43.5 4.3 6.5 5 1 2 7 7 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO25700.1 - 1.1e-25 88.7 33.7 0.00024 20.9 0.6 8.8 8 1 0 8 8 8 6 Tetratricopeptide repeat EF-hand_1 PF00036.32 KOO25700.1 - 9.6e-16 56.1 1.3 3.4e-07 29.3 0.8 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO25700.1 - 1.6e-14 54.1 0.1 6.9e-14 52.0 0.1 2.2 2 0 0 2 2 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO25700.1 - 6.9e-13 47.5 1.5 1.5e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO25700.1 - 9.4e-12 43.9 0.1 0.00021 21.0 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO25700.1 - 3.9e-08 33.0 0.5 0.0038 17.1 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain pair TPR_2 PF07719.17 KOO25700.1 - 1e-05 25.3 22.7 2 8.7 1.9 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat EF-hand_9 PF14658.6 KOO25700.1 - 5.3e-05 23.4 0.1 0.00014 22.1 0.0 1.8 2 0 0 2 2 1 1 EF-hand domain TPR_7 PF13176.6 KOO25700.1 - 0.0011 18.8 23.6 0.31 11.2 0.8 6.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO25700.1 - 0.0084 16.9 31.0 7.5 7.7 2.5 7.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25700.1 - 0.013 16.2 34.1 0.7 10.6 4.0 5.7 3 2 0 4 4 4 0 Tetratricopeptide repeat Coatomer_b_Cpla PF14806.6 KOO25700.1 - 0.045 13.7 0.3 2.2 8.2 0.0 2.9 3 0 0 3 3 3 0 Coatomer beta subunit appendage platform SPARC_Ca_bdg PF10591.9 KOO25700.1 - 0.054 13.8 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TPR_1 PF00515.28 KOO25700.1 - 0.062 13.1 25.5 0.14 12.0 0.0 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25700.1 - 0.078 13.2 18.3 0.49 10.7 0.0 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat EF-hand_4 PF12763.7 KOO25700.1 - 0.19 11.7 0.6 0.8 9.7 0.3 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand TPR_11 PF13414.6 KOO25700.1 - 4.1 7.2 7.0 29 4.4 0.1 3.9 4 0 0 4 4 4 0 TPR repeat Chromate_transp PF02417.15 KOO25702.1 - 1.8e-54 184.1 35.5 2.6e-35 121.9 13.2 2.5 2 1 1 3 3 3 2 Chromate transporter STIMATE PF12400.8 KOO25703.1 - 3.5e-31 108.3 3.7 5.2e-31 107.8 3.7 1.2 1 0 0 1 1 1 1 STIMATE family PsbX PF06596.11 KOO25703.1 - 3.4 7.8 6.0 28 4.8 0.3 2.7 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) PCRF PF03462.18 KOO25704.1 - 1.7e-66 223.8 1.3 1.7e-66 223.8 1.3 1.8 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 KOO25704.1 - 7.9e-35 119.3 1.5 7.9e-35 119.3 1.5 2.3 2 0 0 2 2 2 1 RF-1 domain CBM9_2 PF16011.5 KOO25704.1 - 2.9e-10 40.2 0.0 5.2e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate-binding family 9 CBM9_1 PF06452.11 KOO25704.1 - 0.0022 17.9 0.0 0.0045 16.9 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate family 9 binding domain-like Acyl-CoA_dh_1 PF00441.24 KOO25705.1 - 5.4e-24 85.1 0.6 8.8e-24 84.4 0.6 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 KOO25705.1 - 9.5e-19 67.4 0.0 2.2e-18 66.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 KOO25705.1 - 1.2e-09 38.8 0.1 3.7e-06 27.6 0.0 2.8 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 KOO25705.1 - 6.3e-07 29.7 0.4 1.6e-06 28.5 0.4 1.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HAP1_N PF04849.13 KOO25706.1 - 0.01 15.1 6.3 0.01 15.1 6.3 3.6 1 1 3 4 4 4 0 HAP1 N-terminal conserved region DUF948 PF06103.11 KOO25706.1 - 6.2 7.1 10.0 6 7.2 1.2 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 KOO25706.1 - 6.7 6.8 9.4 0.94 9.5 1.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) CENP-H PF05837.12 KOO25706.1 - 8 6.9 35.5 9.9 6.6 7.4 3.5 3 0 0 3 3 3 0 Centromere protein H (CENP-H) Transket_pyr PF02779.24 KOO25707.1 - 7.3e-12 45.3 0.0 1.1e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 KOO25707.1 - 0.089 11.7 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component Brix PF04427.18 KOO25709.1 - 2.1e-24 86.7 0.0 2.9e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 Brix domain Atrophin-1 PF03154.15 KOO25709.1 - 1.2 7.4 3.7 1.5 7.0 3.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family Pkinase PF00069.25 KOO25710.1 - 1.5e-60 204.8 0.0 2.2e-60 204.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25710.1 - 3.3e-29 102.0 0.0 2.5e-21 76.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 KOO25710.1 - 4.5e-21 75.1 0.0 1.4e-20 73.5 0.0 1.8 2 0 0 2 2 2 1 Response regulator receiver domain Pkinase_fungal PF17667.1 KOO25710.1 - 0.0022 16.8 0.3 0.0047 15.8 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOO25710.1 - 0.038 13.3 0.0 0.73 9.1 0.0 2.2 2 0 0 2 2 2 0 Kinase-like DUF1194 PF06707.11 KOO25710.1 - 0.1 11.8 0.1 0.23 10.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) APH PF01636.23 KOO25710.1 - 0.28 11.1 5.3 0.43 10.5 0.0 2.9 2 2 1 3 3 3 0 Phosphotransferase enzyme family EF-hand_1 PF00036.32 KOO25711.1 - 1.1e-21 74.7 0.2 2e-05 23.8 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO25711.1 - 1.3e-21 76.8 0.0 1.1e-12 48.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO25711.1 - 3.6e-20 70.1 0.0 3e-05 23.6 0.0 4.8 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 KOO25711.1 - 6.5e-12 44.4 2.6 0.0014 18.0 0.0 4.4 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO25711.1 - 5.4e-11 42.2 2.8 0.002 17.9 0.0 4.4 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_9 PF14658.6 KOO25711.1 - 0.0017 18.6 0.0 0.43 10.9 0.0 2.7 2 1 0 2 2 2 1 EF-hand domain Cas_VVA1548 PF09652.10 KOO25711.1 - 0.037 14.2 0.1 3.4 7.9 0.0 2.4 2 0 0 2 2 2 0 Putative CRISPR-associated protein (Cas_VVA1548) Mu-like_Pro PF10123.9 KOO25711.1 - 0.059 12.9 2.3 0.09 12.3 2.3 1.3 1 0 0 1 1 1 0 Mu-like prophage I protein MMR_HSR1 PF01926.23 KOO25712.1 - 9.6e-17 61.1 0.0 1.6e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase NOG1 PF06858.14 KOO25712.1 - 5.8e-13 48.4 0.0 1.2e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) FeoB_N PF02421.18 KOO25712.1 - 2.8e-08 33.5 0.0 4.7e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B NOG1_N PF17835.1 KOO25712.1 - 1.7e-05 24.9 0.0 2.4e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 NOG1 N-terminal helical domain RsgA_GTPase PF03193.16 KOO25712.1 - 0.047 13.6 0.0 0.092 12.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 KOO25712.1 - 0.05 14.0 0.4 0.18 12.2 0.1 1.9 1 1 1 2 2 2 0 AAA ATPase domain DNA_pol_lambd_f PF10391.9 KOO25712.1 - 0.084 12.7 0.0 0.79 9.6 0.0 2.2 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda Peptidase_S9 PF00326.21 KOO25713.1 - 7.7e-38 130.1 0.0 1.5e-36 125.9 0.0 2.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KOO25713.1 - 5.5e-06 26.2 0.4 0.067 12.8 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 KOO25713.1 - 0.02 14.8 0.1 0.04 13.8 0.1 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold PD40 PF07676.12 KOO25713.1 - 0.036 14.0 0.1 14 5.7 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Hydrolase_4 PF12146.8 KOO25713.1 - 0.087 12.1 0.3 5.8 6.1 0.0 2.3 1 1 0 2 2 2 0 Serine aminopeptidase, S33 BAAT_C PF08840.11 KOO25713.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Neprosin PF03080.15 KOO25713.1 - 0.12 11.8 0.3 0.8 9.0 0.1 2.0 2 0 0 2 2 2 0 Neprosin LIP PF03583.14 KOO25713.1 - 0.17 11.2 0.2 0.31 10.3 0.2 1.4 1 0 0 1 1 1 0 Secretory lipase Response_reg PF00072.24 KOO25714.1 - 3.3e-18 65.9 0.0 2.5e-08 34.1 0.0 2.7 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 KOO25714.1 - 4.1e-12 46.6 0.1 8.1e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 KOO25715.1 - 2.6e-15 56.4 0.0 1.4e-09 37.9 0.0 2.1 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 KOO25715.1 - 6.8e-14 52.1 0.0 3.7e-08 33.6 0.0 2.1 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 KOO25715.1 - 1.4e-07 31.7 0.0 3.7e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.7 KOO25715.1 - 5.4e-07 29.5 0.0 0.0085 16.1 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 KOO25715.1 - 0.006 16.8 0.0 0.0089 16.3 0.0 1.3 1 0 0 1 1 1 1 PAS fold LRR_8 PF13855.6 KOO25716.1 - 1.8e-20 72.5 15.4 6.1e-09 35.5 2.3 5.0 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 KOO25716.1 - 1.7e-13 50.5 18.0 0.00044 20.6 1.2 5.9 3 3 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO25716.1 - 3.9e-09 35.8 10.9 4.8 8.1 0.0 8.4 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_6 PF13516.6 KOO25716.1 - 0.0023 17.8 17.2 2.9 8.2 0.1 6.3 7 0 0 7 7 7 3 Leucine Rich repeat Asp PF00026.23 KOO25718.1 - 4.3e-25 88.8 0.0 1.7e-20 73.7 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease PDZ PF00595.24 KOO25719.1 - 0.12 12.7 0.1 0.17 12.3 0.1 1.3 1 0 0 1 1 1 0 PDZ domain PDZ_2 PF13180.6 KOO25719.1 - 0.16 12.3 0.0 0.23 11.8 0.0 1.2 1 0 0 1 1 1 0 PDZ domain IRK_C PF17655.1 KOO25720.1 - 4.4e-10 39.4 0.0 7.6e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KOO25720.1 - 3.6e-09 36.6 8.2 5.9e-08 32.6 1.3 2.2 1 1 1 2 2 2 2 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 KOO25720.1 - 0.019 14.9 6.7 0.035 14.1 6.7 1.5 1 0 0 1 1 1 0 Ion channel Dynein_C PF18199.1 KOO25722.1 - 1.9e-90 303.2 0.0 4.3e-90 302.0 0.0 1.6 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KOO25722.1 - 3.2e-82 274.9 0.0 9.1e-81 270.2 0.0 2.4 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 KOO25722.1 - 3.1e-79 266.0 0.0 5.2e-79 265.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 KOO25722.1 - 1.7e-53 180.8 1.0 3.2e-53 179.9 0.1 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KOO25722.1 - 4.5e-48 163.2 0.0 1.1e-47 161.9 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 KOO25722.1 - 2.4e-44 151.8 11.4 3.6e-44 151.2 11.4 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KOO25722.1 - 2.9e-42 143.5 0.0 2.5e-39 134.0 0.0 2.8 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 KOO25722.1 - 4.4e-19 68.8 0.1 1.3e-18 67.3 0.1 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KOO25722.1 - 8.4e-19 67.6 0.1 5.5e-18 65.0 0.0 2.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 KOO25722.1 - 6.8e-08 32.6 0.1 0.00028 20.9 0.0 3.3 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA PF00004.29 KOO25722.1 - 0.02 15.3 0.0 0.099 13.1 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Taxilin PF09728.9 KOO25722.1 - 0.024 13.8 0.3 0.024 13.8 0.3 1.6 2 0 0 2 2 2 0 Myosin-like coiled-coil protein UPF0242 PF06785.11 KOO25722.1 - 0.19 11.8 1.0 0.99 9.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 KOO25722.1 - 1.4 7.8 11.9 0.1 11.5 1.3 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 KOO25722.1 - 5.9 7.1 7.2 22 5.3 1.9 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DHR10 PF18595.1 KOO25722.1 - 6.1 6.9 11.1 3.1 7.9 1.9 3.0 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Filament PF00038.21 KOO25722.1 - 6.4 6.2 8.3 3.2 7.2 0.6 2.5 2 0 0 2 2 2 0 Intermediate filament protein DUF4589 PF15252.6 KOO25723.1 - 1 9.3 6.0 0.21 11.6 1.1 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4589) Actin PF00022.19 KOO25724.1 - 8.9e-110 367.1 0.0 2.1e-108 362.6 0.0 2.0 1 1 0 1 1 1 1 Actin zf-C2H2 PF00096.26 KOO25725.1 - 1.1e-22 79.2 48.6 8.3e-06 26.0 4.2 6.7 6 1 1 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO25725.1 - 2e-21 75.4 46.2 5.9e-05 23.3 1.5 7.4 7 1 0 7 7 7 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO25725.1 - 1.3e-16 59.8 38.5 0.0035 18.0 1.1 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOO25725.1 - 0.00027 20.8 31.1 0.038 14.0 0.2 6.1 6 0 0 6 6 6 4 C2H2-type zinc finger CHORD PF04968.12 KOO25725.1 - 0.0035 18.0 28.2 1.4 9.7 0.6 5.4 2 2 3 5 5 5 2 CHORD Peptidase_C21 PF05381.12 KOO25725.1 - 0.043 14.2 0.1 4.1 7.8 0.0 3.1 2 1 1 3 3 3 0 Tymovirus endopeptidase Fer2 PF00111.27 KOO25725.1 - 0.52 10.3 0.1 0.52 10.3 0.1 5.3 6 0 0 6 6 6 0 2Fe-2S iron-sulfur cluster binding domain zf-C2H2_2 PF12756.7 KOO25725.1 - 1.1 9.7 12.8 89 3.5 9.7 3.8 3 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) FANCL_C PF11793.8 KOO25725.1 - 1.2 9.4 29.0 3.4 7.9 0.2 7.0 2 2 5 7 7 7 0 FANCL C-terminal domain zf-C2H2_jaz PF12171.8 KOO25725.1 - 1.9 8.8 24.3 8.6 6.8 0.1 6.1 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KOO25725.1 - 2.6 7.9 34.1 0.92 9.3 0.8 6.6 6 0 0 6 6 6 0 C2H2-type zinc-finger domain zf-C2H2_aberr PF17017.5 KOO25725.1 - 8.4 6.5 17.3 39 4.3 2.3 4.9 2 1 3 5 5 5 0 Aberrant zinc-finger IQ PF00612.27 KOO25726.1 - 0.0093 15.7 3.0 0.02 14.6 0.1 2.6 2 0 0 2 2 2 1 IQ calmodulin-binding motif SYF2 PF08231.12 KOO25728.1 - 1.8e-27 96.7 8.9 1.8e-27 96.7 8.9 2.3 1 1 1 2 2 2 1 SYF2 splicing factor GIDA_assoc PF13932.6 KOO25728.1 - 0.19 11.9 6.9 0.23 11.6 6.7 1.3 1 1 0 1 1 1 0 GidA associated domain U-box PF04564.15 KOO25730.1 - 3.5e-15 55.9 0.0 5.2e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO25730.1 - 0.00048 19.9 0.0 0.00097 18.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Sel1 PF08238.12 KOO25730.1 - 0.001 19.7 0.1 0.0032 18.1 0.1 2.0 1 0 0 1 1 1 1 Sel1 repeat zf-NOSIP PF15906.5 KOO25730.1 - 0.045 13.9 0.0 0.086 13.0 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein GH97_C PF14509.6 KOO25730.1 - 0.045 14.0 3.2 5.2 7.4 0.2 2.8 3 0 0 3 3 3 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation V_ATPase_I PF01496.19 KOO25730.1 - 0.88 7.4 5.5 0.91 7.4 5.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SAPS PF04499.15 KOO25730.1 - 1.1 7.9 5.5 1.3 7.7 5.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF5523 PF17661.1 KOO25730.1 - 1.3 8.7 14.0 1.6 8.3 14.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) GREB1 PF15782.5 KOO25730.1 - 4.1 4.4 11.9 4.8 4.2 11.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RR_TM4-6 PF06459.12 KOO25730.1 - 6.1 6.6 19.3 9.1 6.0 19.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 U-box PF04564.15 KOO25731.1 - 1.4e-15 57.2 0.0 2.1e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO25731.1 - 4.6e-13 49.4 3.1 7.5e-07 29.6 0.3 2.8 2 0 0 2 2 2 2 Sel1 repeat zf-Nse PF11789.8 KOO25731.1 - 0.00056 19.7 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO25731.1 - 0.05 13.7 0.0 0.099 12.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Asp-B-Hydro_N PF05279.11 KOO25731.1 - 0.063 13.3 18.1 0.085 12.9 18.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF572 PF04502.13 KOO25731.1 - 0.2 11.2 9.7 0.24 11.0 9.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SOBP PF15279.6 KOO25731.1 - 0.72 10.4 3.7 0.85 10.2 3.7 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Dsh_C PF12316.8 KOO25731.1 - 0.83 10.0 6.9 1.3 9.4 6.9 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal SAPS PF04499.15 KOO25731.1 - 1.8 7.3 6.2 1.9 7.1 6.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BAF1_ABF1 PF04684.13 KOO25731.1 - 2.7 6.9 13.5 3.6 6.5 13.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PMSI1 PF15322.6 KOO25731.1 - 3.1 7.1 13.2 4.3 6.7 13.2 1.1 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative DUF966 PF06136.13 KOO25731.1 - 5.8 6.5 11.4 7.3 6.2 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) GREB1 PF15782.5 KOO25731.1 - 7 3.6 11.2 8.4 3.4 11.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 KOO25731.1 - 7.9 5.1 11.9 10 4.7 11.9 1.2 1 0 0 1 1 1 0 Presenilin Myosin_head PF00063.21 KOO25732.1 - 1.6e-201 671.1 0.0 3e-201 670.2 0.0 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) Arm PF00514.23 KOO25732.1 - 4.7e-29 99.5 37.9 0.0063 16.5 0.1 13.9 13 1 0 13 13 13 10 Armadillo/beta-catenin-like repeat Myb_DNA-binding PF00249.31 KOO25732.1 - 2.5e-15 56.4 0.1 8.7e-15 54.6 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO25732.1 - 3.3e-10 40.1 0.2 8.3e-10 38.8 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain AAA_22 PF13401.6 KOO25732.1 - 0.061 13.6 0.0 0.23 11.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO25732.1 - 0.77 10.1 0.0 0.77 10.1 0.0 3.7 3 1 0 3 3 3 0 AAA ATPase domain Peptidase_C25_C PF03785.14 KOO25732.1 - 1.5 8.7 18.1 5.6 6.9 0.3 6.9 4 1 3 7 7 7 0 Peptidase family C25, C terminal ig-like domain Borrelia_P83 PF05262.11 KOO25732.1 - 5.9 5.3 37.6 16 3.9 37.6 1.6 1 0 0 1 1 1 0 Borrelia P83/100 protein Filamin PF00630.19 KOO25734.1 - 9.5e-31 106.7 0.2 7.2e-15 55.7 0.0 4.8 5 0 0 5 5 5 3 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO25734.1 - 2.3e-05 24.6 10.7 0.0019 18.5 0.1 3.9 3 1 1 4 4 4 2 Invasin, domain 3 Neurexophilin PF06312.12 KOO25734.1 - 0.0089 15.5 0.2 0.023 14.1 0.2 1.6 1 0 0 1 1 1 1 Neurexophilin Metallophos PF00149.28 KOO25735.1 - 1.2e-15 58.5 0.1 1.9e-15 57.9 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO25735.1 - 3.2e-09 37.2 0.0 3.7e-08 33.7 0.0 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Mre11_DNA_bind PF04152.14 KOO25735.1 - 0.00036 20.9 0.0 0.00053 20.3 0.0 1.3 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Form_Nir_trans PF01226.17 KOO25737.1 - 6.2e-50 169.7 20.5 8.4e-50 169.3 20.5 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Lipase_3 PF01764.25 KOO25738.1 - 2.1e-39 134.7 0.0 2.7e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 KOO25738.1 - 4e-05 23.0 0.0 5.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO25738.1 - 0.0027 18.3 0.0 0.0038 17.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.22 KOO25738.1 - 0.0036 17.3 0.1 0.0058 16.6 0.1 1.3 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.8 KOO25738.1 - 0.012 15.2 0.4 0.082 12.5 0.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_8 PF06259.12 KOO25738.1 - 0.028 14.1 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase AAA PF00004.29 KOO25739.1 - 5.4e-39 133.6 0.0 2.5e-37 128.3 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOO25739.1 - 1.3e-07 32.0 0.2 0.0011 19.2 0.1 3.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO25739.1 - 9.3e-07 29.4 5.3 6.2e-06 26.7 0.1 3.5 3 1 0 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 KOO25739.1 - 1.8e-06 28.2 0.0 3.5e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_lid_3 PF17862.1 KOO25739.1 - 2.9e-05 23.8 0.3 0.00012 21.8 0.3 2.0 1 0 0 1 1 1 1 AAA+ lid domain NACHT PF05729.12 KOO25739.1 - 7.4e-05 22.7 0.0 0.025 14.5 0.0 3.0 3 0 0 3 3 3 1 NACHT domain AAA_5 PF07728.14 KOO25739.1 - 7.6e-05 22.7 0.0 0.00021 21.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KOO25739.1 - 9e-05 23.0 0.0 0.00016 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO25739.1 - 0.00013 22.2 0.0 0.00029 21.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOO25739.1 - 0.00089 19.5 0.0 0.0019 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 KOO25739.1 - 0.0014 18.6 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain Mg_chelatase PF01078.21 KOO25739.1 - 0.0074 15.7 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 KOO25739.1 - 0.0097 15.7 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 KOO25739.1 - 0.011 16.2 0.0 0.018 15.4 0.0 1.3 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 KOO25739.1 - 0.015 15.1 0.0 0.4 10.4 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 KOO25739.1 - 0.015 14.9 1.6 0.5 9.9 0.0 3.2 2 1 1 3 3 3 0 AAA domain TsaE PF02367.17 KOO25739.1 - 0.02 14.9 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 KOO25739.1 - 0.02 14.1 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_3 PF07726.11 KOO25739.1 - 0.034 14.0 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 KOO25739.1 - 0.071 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 KaiC Zeta_toxin PF06414.12 KOO25739.1 - 0.093 12.0 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.6 KOO25739.1 - 0.2 11.7 0.0 0.42 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOO25739.1 - 0.28 10.7 0.0 0.55 9.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region STIMATE PF12400.8 KOO25740.1 - 3.1e-23 82.7 2.6 4.2e-23 82.2 2.6 1.2 1 0 0 1 1 1 1 STIMATE family FixS PF03597.15 KOO25740.1 - 0.022 14.5 3.8 0.022 14.5 3.8 1.9 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type FixQ PF05545.11 KOO25740.1 - 1.9 8.5 9.5 3.7 7.6 5.6 2.7 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ CENP-F_leu_zip PF10473.9 KOO25741.1 - 3.6e-05 23.8 9.8 3.6e-05 23.8 9.8 2.5 2 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 End3 PF12761.7 KOO25741.1 - 0.011 16.0 5.4 0.011 16.0 5.4 2.0 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Noelin-1 PF12308.8 KOO25741.1 - 0.14 12.1 5.2 0.25 11.4 0.4 2.5 1 1 1 2 2 2 0 Neurogenesis glycoprotein TSC22 PF01166.18 KOO25741.1 - 1 9.7 5.8 0.6 10.5 0.5 2.9 3 0 0 3 3 3 0 TSC-22/dip/bun family YabA PF06156.13 KOO25741.1 - 3.1 8.5 12.3 5 7.8 3.4 3.1 1 1 2 3 3 3 0 Initiation control protein YabA COG2 PF06148.11 KOO25741.1 - 5.6 7.0 14.4 0.066 13.3 2.8 2.5 1 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ATG16 PF08614.11 KOO25741.1 - 8.5 6.6 30.7 0.11 12.7 13.8 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) cobW PF02492.19 KOO25742.1 - 3.2e-42 144.1 0.0 4.1e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 KOO25742.1 - 0.00095 19.1 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 KOO25742.1 - 0.0051 17.2 0.1 0.013 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain MeaB PF03308.16 KOO25742.1 - 0.0068 15.4 0.8 0.025 13.5 0.8 1.9 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 KOO25742.1 - 0.0091 16.3 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain HTH_42 PF06224.12 KOO25742.1 - 0.012 15.1 0.1 0.021 14.4 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain T2SSE PF00437.20 KOO25742.1 - 0.018 14.1 0.1 0.034 13.2 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Viral_helicase1 PF01443.18 KOO25742.1 - 0.082 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 KOO25742.1 - 0.1 12.7 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO25742.1 - 0.13 12.0 0.1 0.33 10.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 KOO25742.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 KOO25742.1 - 0.2 11.7 0.0 0.34 10.9 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FUN14 PF04930.15 KOO25745.1 - 1.8e-17 63.5 4.7 3.6e-17 62.6 4.7 1.5 1 0 0 1 1 1 1 FUN14 family Dockerin_1 PF00404.18 KOO25745.1 - 0.011 16.0 0.3 0.017 15.3 0.3 1.2 1 0 0 1 1 1 0 Dockerin type I domain DUF4349 PF14257.6 KOO25745.1 - 0.021 14.3 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) EF-hand_5 PF13202.6 KOO25745.1 - 0.04 13.4 0.5 0.073 12.6 0.5 1.4 1 0 0 1 1 1 0 EF hand ABC_tran_CTD PF16326.5 KOO25745.1 - 0.051 13.8 0.5 0.093 13.0 0.5 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain cNMP_binding PF00027.29 KOO25746.1 - 2.9e-13 49.7 0.1 3.4e-06 27.0 0.0 3.4 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain FdhE PF04216.12 KOO25746.1 - 0.0031 17.4 2.2 0.0035 17.3 0.2 2.0 2 0 0 2 2 2 1 Protein involved in formate dehydrogenase formation zf-ribbon_3 PF13248.6 KOO25746.1 - 0.023 14.1 0.6 0.047 13.1 0.6 1.5 1 0 0 1 1 1 0 zinc-ribbon domain MEDS PF14417.6 KOO25746.1 - 0.038 13.8 0.3 0.45 10.3 0.0 2.4 2 0 0 2 2 2 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain DUF35_N PF12172.8 KOO25746.1 - 0.049 13.5 0.4 0.11 12.3 0.4 1.6 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc-ribbon_6 PF10005.9 KOO25746.1 - 0.089 13.5 2.4 0.12 13.1 1.1 1.9 2 0 0 2 2 2 0 zinc-ribbon domain Glyco_hydro_7 PF00840.20 KOO25747.1 - 7.6e-19 67.7 2.6 3.4e-09 35.9 0.2 3.6 2 1 1 3 3 3 3 Glycosyl hydrolase family 7 CDC45 PF02724.14 KOO25747.1 - 0.0091 14.4 5.9 0.016 13.5 5.9 1.3 1 1 0 1 1 1 1 CDC45-like protein Bestrophin PF01062.21 KOO25748.1 - 9.9e-10 38.3 0.0 1.3e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Ank_2 PF12796.7 KOO25749.1 - 1.5e-17 63.9 10.1 6.1e-11 42.8 2.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO25749.1 - 9.7e-14 51.1 6.1 0.00017 21.8 0.4 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KOO25749.1 - 3.8e-12 46.5 0.7 3.9e-08 33.7 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO25749.1 - 7.6e-12 44.3 0.5 0.082 13.5 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KOO25749.1 - 9e-12 45.0 5.9 2.1e-05 24.7 0.4 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) DEAD PF00270.29 KOO25750.1 - 1.9e-45 154.8 0.0 4e-45 153.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO25750.1 - 5.4e-23 81.5 0.0 2e-22 79.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KOO25750.1 - 1.8e-16 60.1 0.0 3.8e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KOO25750.1 - 0.00076 19.5 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TM231 PF10149.9 KOO25751.1 - 4.4e-42 144.5 0.0 5.2e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein 231 Translin PF01997.16 KOO25752.1 - 2.1e-28 99.8 0.0 7.5e-19 68.5 0.0 2.2 2 0 0 2 2 2 2 Translin family Vta1_C PF18097.1 KOO25752.1 - 0.0005 19.7 0.1 0.0015 18.2 0.1 1.8 1 0 0 1 1 1 1 Vta1 C-terminal domain Ion_trans PF00520.31 KOO25755.1 - 4.7e-198 654.8 51.7 3.1e-61 206.7 5.8 4.0 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO25755.1 - 9.3e-06 24.6 8.5 9.3e-06 24.6 8.5 9.4 8 2 1 10 10 10 7 Polycystin cation channel GPHH PF16905.5 KOO25755.1 - 8.6e-05 22.2 0.0 0.00033 20.3 0.0 2.0 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Chloroa_b-bind PF00504.21 KOO25756.1 - 1e-31 110.7 0.1 1.5e-31 110.1 0.1 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein MutS_V PF00488.21 KOO25757.1 - 3.8e-23 82.5 0.0 7.8e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 MutS domain V Smr PF01713.21 KOO25757.1 - 9.5e-12 45.1 0.6 6.1e-11 42.5 0.0 2.7 3 0 0 3 3 3 1 Smr domain Myb_DNA-binding PF00249.31 KOO25757.1 - 5.6e-05 23.3 0.0 0.00011 22.3 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Nop25 PF09805.9 KOO25757.1 - 0.36 11.3 5.1 0.96 9.9 5.1 1.7 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Mito_fiss_reg PF05308.11 KOO25757.1 - 1.2 9.2 14.0 0.27 11.3 7.9 2.5 2 0 0 2 2 2 0 Mitochondrial fission regulator MAT1 PF06391.13 KOO25757.1 - 1.7 8.4 7.8 3.8 7.3 7.8 1.5 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 MFS_1 PF07690.16 KOO25758.1 - 1.5e-30 106.4 25.5 5.6e-20 71.6 16.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO25758.1 - 1.5e-07 30.6 9.2 0.00016 20.7 2.2 3.0 1 1 2 3 3 3 3 Sugar (and other) transporter MFS_1_like PF12832.7 KOO25758.1 - 3.1e-05 23.0 3.6 0.00011 21.2 1.8 2.1 1 1 1 2 2 2 1 MFS_1 like family MFS_2 PF13347.6 KOO25758.1 - 0.00075 18.2 7.7 0.013 14.1 1.8 2.3 1 1 1 2 2 2 2 MFS/sugar transport protein TRI12 PF06609.13 KOO25758.1 - 0.066 11.6 6.7 0.033 12.6 3.9 1.7 1 1 1 2 2 2 0 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 KOO25758.1 - 0.42 8.8 5.3 2.4 6.3 3.7 2.7 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 KOO25758.1 - 0.6 8.4 8.6 0.19 10.1 5.4 1.6 1 1 1 2 2 2 0 Transmembrane secretion effector Anoctamin PF04547.12 KOO25759.1 - 1.4e-88 297.7 0.2 2.6e-88 296.8 0.2 1.4 1 1 0 1 1 1 1 Calcium-activated chloride channel PAN_4 PF14295.6 KOO25762.1 - 0.16 11.9 1.3 0.43 10.5 1.3 1.8 1 0 0 1 1 1 0 PAN domain IQ PF00612.27 KOO25764.1 - 0.00077 19.0 7.7 0.046 13.5 0.7 3.2 2 0 0 2 2 2 2 IQ calmodulin-binding motif eIF3_subunit PF08597.10 KOO25764.1 - 0.018 15.0 3.6 0.018 15.0 3.6 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Ndc1_Nup PF09531.10 KOO25764.1 - 0.12 11.1 0.3 0.2 10.3 0.3 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3464 PF11947.8 KOO25764.1 - 0.24 11.1 3.6 0.53 10.0 3.6 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 EF-hand_6 PF13405.6 KOO25765.1 - 6.4e-10 38.2 0.2 0.00055 19.6 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO25765.1 - 6.5e-08 32.9 2.4 6.1e-05 23.4 0.2 2.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO25765.1 - 1.4e-07 30.5 0.1 0.016 14.7 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO25765.1 - 3.9e-06 26.1 0.6 0.034 13.6 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO25765.1 - 2.9e-05 23.8 0.1 8.3e-05 22.4 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair DUF3161 PF11362.8 KOO25765.1 - 0.15 12.1 0.1 0.3 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3161) Nitroreductase PF00881.24 KOO25766.1 - 1.9e-16 60.6 2.3 2e-13 50.7 2.3 2.1 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 KOO25766.1 - 0.00027 20.6 0.1 0.38 10.3 0.0 2.3 2 1 0 2 2 2 2 Putative TM nitroreductase CRAL_TRIO PF00650.20 KOO25768.1 - 1.3e-15 57.5 0.0 1.9e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain MatE PF01554.18 KOO25770.1 - 7.6e-34 116.7 22.1 1.2e-22 80.3 8.7 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 KOO25770.1 - 2.9e-18 66.3 21.0 9.4e-14 51.7 6.1 2.8 3 0 0 3 3 3 2 Polysaccharide biosynthesis C-terminal domain DUF3619 PF12279.8 KOO25770.1 - 4.9 7.5 6.9 0.87 9.9 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) Bromodomain PF00439.25 KOO25771.1 - 1.4e-16 60.3 0.0 2.1e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 KOO25771.1 - 4.5e-12 45.7 32.6 3.7e-09 36.3 2.9 3.8 4 0 0 4 4 4 2 PHD-finger MBD PF01429.19 KOO25771.1 - 4.3e-07 29.6 0.0 7.9e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Methyl-CpG binding domain zf-HC5HC2H PF13771.6 KOO25771.1 - 0.0038 17.4 12.5 0.071 13.4 0.9 2.6 2 0 0 2 2 2 2 PHD-like zinc-binding domain PHD_4 PF16866.5 KOO25771.1 - 0.03 14.4 15.4 0.045 13.8 5.0 2.8 2 0 0 2 2 2 0 PHD-finger zf-HC5HC2H_2 PF13832.6 KOO25771.1 - 0.19 11.9 11.1 1.4 9.1 0.1 2.5 2 0 0 2 2 2 0 PHD-zinc-finger like domain zf-C3HC4 PF00097.25 KOO25772.1 - 7.3e-09 35.4 24.5 7.5e-06 25.7 9.0 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO25772.1 - 2e-08 33.9 9.9 2e-08 33.9 9.9 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO25772.1 - 2.5e-08 33.6 24.1 2.7e-06 27.1 9.6 2.9 3 0 0 3 3 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOO25772.1 - 2.9e-08 33.7 23.9 6.4e-08 32.6 9.6 2.8 2 0 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KOO25772.1 - 3.5e-07 30.1 23.4 7.2e-06 25.9 5.1 3.3 2 1 1 3 3 3 2 RING-type zinc-finger Prok-RING_4 PF14447.6 KOO25772.1 - 0.00011 22.0 27.1 0.00031 20.5 8.2 3.3 3 1 1 4 4 3 2 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KOO25772.1 - 0.00015 21.5 1.8 0.00015 21.5 1.8 4.4 4 0 0 4 4 4 2 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.6 KOO25772.1 - 0.00057 20.2 29.8 0.00096 19.4 13.5 2.9 2 0 0 2 2 2 1 Ring finger domain ZZ PF00569.17 KOO25772.1 - 0.00067 19.4 2.2 0.00067 19.4 2.2 2.6 4 0 0 4 4 2 1 Zinc finger, ZZ type zf-RING_5 PF14634.6 KOO25772.1 - 0.0027 17.6 7.8 0.0027 17.6 7.8 3.2 3 0 0 3 3 3 2 zinc-RING finger domain Gin PF10764.9 KOO25772.1 - 0.46 10.5 4.0 0.78 9.8 1.1 2.5 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin Ribonuc_red_2_N PF08471.10 KOO25772.1 - 3 8.1 5.5 4.4 7.5 0.1 3.4 3 1 0 3 3 3 0 Class II vitamin B12-dependent ribonucleotide reductase zf-RING_10 PF16685.5 KOO25772.1 - 3.3 7.9 26.0 2.6 8.2 9.6 2.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 AAA PF00004.29 KOO25773.1 - 2.9e-42 144.2 0.0 5.4e-42 143.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO25773.1 - 3.9e-09 36.2 1.1 7e-09 35.4 0.4 1.8 2 0 0 2 2 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KOO25773.1 - 1e-08 35.0 0.0 7e-08 32.3 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 KOO25773.1 - 1e-07 32.5 0.0 5.3e-05 23.7 0.0 2.7 2 1 1 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 KOO25773.1 - 1.8e-06 28.2 0.0 5.2e-06 26.7 0.0 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 KOO25773.1 - 1.4e-05 24.9 0.0 2.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KOO25773.1 - 5.1e-05 23.3 0.1 0.0011 19.0 0.1 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO25773.1 - 7.7e-05 23.0 0.1 0.0077 16.5 0.0 2.6 2 1 1 3 3 2 1 AAA domain DUF815 PF05673.13 KOO25773.1 - 0.00066 18.9 0.0 0.0011 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 KOO25773.1 - 0.00093 18.5 0.0 0.0018 17.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_7 PF12775.7 KOO25773.1 - 0.0015 18.0 0.0 0.0046 16.5 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activat PF00158.26 KOO25773.1 - 0.0024 17.6 0.0 0.0093 15.7 0.0 2.0 2 1 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 KOO25773.1 - 0.0049 16.6 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KOO25773.1 - 0.0059 17.0 0.0 0.017 15.5 0.0 1.8 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 KOO25773.1 - 0.0079 15.6 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KOO25773.1 - 0.011 16.3 0.0 0.035 14.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO25773.1 - 0.016 15.3 0.0 0.034 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 KOO25773.1 - 0.02 14.7 0.0 0.045 13.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOO25773.1 - 0.021 14.5 0.1 0.057 13.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain DUF4200 PF13863.6 KOO25773.1 - 0.022 15.2 3.0 0.046 14.1 3.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) AAA_24 PF13479.6 KOO25773.1 - 0.022 14.5 0.0 0.066 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 KOO25773.1 - 0.026 13.9 0.1 0.11 11.8 0.0 2.0 3 0 0 3 3 3 0 KaiC AAA_14 PF13173.6 KOO25773.1 - 0.027 14.5 0.0 0.056 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KOO25773.1 - 0.04 13.9 0.0 0.073 13.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KOO25773.1 - 0.041 14.1 0.0 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 KOO25773.1 - 0.043 13.6 0.1 0.36 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 KOO25773.1 - 0.06 12.4 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 KOO25773.1 - 0.069 12.7 0.1 0.38 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 KOO25773.1 - 0.072 12.5 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein GAS PF13851.6 KOO25773.1 - 0.094 12.1 2.5 0.15 11.4 2.5 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Zeta_toxin PF06414.12 KOO25773.1 - 0.098 11.9 0.5 0.42 9.9 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin V-SNARE_C PF12352.8 KOO25774.1 - 7.4e-17 61.4 10.9 2.9e-16 59.5 2.2 2.4 2 0 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 KOO25774.1 - 0.00091 19.1 1.5 0.0057 16.5 0.1 2.6 2 1 1 3 3 3 1 Sec20 DUF948 PF06103.11 KOO25774.1 - 0.078 13.2 0.5 13 6.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PI_PP_I PF18363.1 KOO25774.1 - 0.084 13.1 0.6 0.21 11.8 0.2 1.8 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain NDUF_C2 PF06374.11 KOO25774.1 - 0.11 12.7 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) G6B PF15096.6 KOO25774.1 - 0.14 11.9 1.3 2.1 8.1 0.0 2.8 1 1 1 3 3 3 0 G6B family KxDL PF10241.9 KOO25774.1 - 1.1 9.6 6.8 0.43 10.9 1.1 2.9 2 2 1 3 3 3 0 Uncharacterized conserved protein HNOBA PF07701.14 KOO25774.1 - 2 7.8 5.8 2.2 7.7 1.2 2.1 2 0 0 2 2 2 0 Heme NO binding associated CENP-Q PF13094.6 KOO25774.1 - 2.9 8.1 10.6 9.6 6.4 10.6 1.9 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit TEX13 PF15186.6 KOO25774.1 - 6.6 6.4 10.6 3.5 7.3 6.0 2.1 1 1 1 2 2 2 0 Testis-expressed sequence 13 protein family Chloroa_b-bind PF00504.21 KOO25775.1 - 0.047 14.2 0.1 0.55 10.7 0.0 2.0 1 1 1 2 2 2 0 Chlorophyll A-B binding protein PPR_2 PF13041.6 KOO25776.1 - 8.9e-41 137.9 0.0 2.5e-06 27.6 0.0 10.5 6 2 5 11 11 11 9 PPR repeat family PPR PF01535.20 KOO25776.1 - 3.3e-33 111.6 1.1 0.00026 21.0 0.0 13.1 13 1 0 13 13 13 6 PPR repeat PPR_3 PF13812.6 KOO25776.1 - 1e-22 79.9 0.0 8.4e-07 29.0 0.0 6.6 4 2 4 8 8 8 6 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO25776.1 - 3e-19 69.2 4.3 2.9e-07 30.1 0.3 5.2 2 1 2 4 4 4 4 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 KOO25776.1 - 1e-10 41.1 0.0 0.0047 16.6 0.0 8.4 8 0 0 8 8 8 1 PPR repeat Smr PF01713.21 KOO25776.1 - 0.0027 18.0 2.2 0.0031 17.9 0.5 2.1 2 0 0 2 2 2 1 Smr domain ANAPC3 PF12895.7 KOO25776.1 - 0.12 12.6 6.4 0.12 12.6 0.7 3.7 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 FtsK_gamma PF09397.10 KOO25776.1 - 3.9 7.4 5.2 1e+02 2.8 0.0 4.4 5 0 0 5 5 5 0 Ftsk gamma domain SET PF00856.28 KOO25777.1 - 2.1e-16 60.8 0.1 2.2e-15 57.5 0.1 2.2 1 1 0 1 1 1 1 SET domain zf-RING_2 PF13639.6 KOO25778.1 - 6.7e-10 39.1 13.2 1.3e-09 38.3 13.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KOO25778.1 - 3e-08 33.8 9.3 7.4e-08 32.6 9.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOO25778.1 - 4.9e-08 32.7 9.0 9.8e-08 31.8 9.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO25778.1 - 4e-07 29.8 12.7 8.1e-07 28.8 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO25778.1 - 5.5e-07 29.5 5.9 1.5e-06 28.2 5.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 KOO25778.1 - 7.8e-05 22.7 5.3 0.00017 21.6 5.3 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 KOO25778.1 - 0.00016 21.3 4.5 0.00037 20.2 4.5 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 KOO25778.1 - 0.00041 20.1 10.6 0.0007 19.4 10.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO25778.1 - 0.00073 19.4 11.4 0.0013 18.6 11.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KOO25778.1 - 0.00088 19.1 8.2 0.00088 19.1 8.2 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 KOO25778.1 - 0.029 14.0 8.6 0.06 13.0 8.6 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 KOO25778.1 - 0.054 13.3 5.4 0.11 12.3 5.4 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 KOO25778.1 - 0.078 12.8 7.2 0.2 11.5 7.2 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 KOO25778.1 - 0.19 11.9 8.7 0.39 10.9 8.7 1.5 1 0 0 1 1 1 0 RING-variant domain Zf_RING PF16744.5 KOO25778.1 - 0.83 9.8 4.4 2.2 8.4 4.4 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger FANCL_C PF11793.8 KOO25778.1 - 1.7 8.9 5.4 4.3 7.6 5.4 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain MscS_porin PF12795.7 KOO25778.1 - 3.9 6.9 10.5 7.4 6.1 0.2 3.0 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain zf-RING_10 PF16685.5 KOO25778.1 - 5.2 7.3 9.0 12 6.2 9.0 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 PAP2 PF01569.21 KOO25779.1 - 3.2e-14 52.9 0.3 3.2e-14 52.9 0.3 2.2 3 0 0 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.6 KOO25779.1 - 5.2e-05 23.0 4.1 5.2e-05 23.0 4.1 2.8 2 2 0 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 KOO25779.1 - 0.2 11.8 2.0 0.65 10.1 0.0 2.5 2 1 1 3 3 3 0 Divergent PAP2 family Chloroa_b-bind PF00504.21 KOO25780.1 - 2.3e-28 99.8 0.0 3.9e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Ank_5 PF13857.6 KOO25781.1 - 1.4e-13 50.8 0.0 5.7e-07 29.7 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO25781.1 - 2.2e-13 50.6 0.0 2.1e-10 41.0 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO25781.1 - 8.7e-12 45.3 0.1 8.7e-09 35.8 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO25781.1 - 5.2e-07 29.5 0.0 0.23 12.1 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Cyclase PF04199.13 KOO25781.1 - 0.015 15.5 0.1 0.12 12.6 0.0 2.0 1 1 1 2 2 2 0 Putative cyclase Ank PF00023.30 KOO25781.1 - 0.019 15.4 0.1 6.9 7.3 0.0 2.9 4 0 0 4 4 4 0 Ankyrin repeat ABC_tran PF00005.27 KOO25782.1 - 1.1e-19 71.3 0.0 1.7e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 KOO25782.1 - 0.0013 18.7 0.0 0.0047 16.9 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 KOO25782.1 - 0.0034 17.3 0.1 0.58 9.9 0.1 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO25782.1 - 0.0059 16.1 0.0 0.36 10.2 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_33 PF13671.6 KOO25782.1 - 0.013 15.6 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO25782.1 - 0.024 14.4 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Methyltr_RsmB-F PF01189.17 KOO25783.1 - 4.9e-68 228.7 0.0 7.7e-68 228.1 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 KOO25783.1 - 5.1e-09 36.5 0.0 1.3e-08 35.2 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltransf_25 PF13649.6 KOO25783.1 - 1.3e-05 25.9 0.0 3.2e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO25783.1 - 2.4e-05 24.2 0.0 3.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 KOO25783.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 KOO25783.1 - 0.013 15.2 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.12 KOO25783.1 - 0.022 14.5 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) MTS PF05175.14 KOO25783.1 - 0.19 11.3 0.0 0.34 10.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain AAA_12 PF13087.6 KOO25784.1 - 4.1e-47 160.4 0.0 6.2e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain Hydrolase_4 PF12146.8 KOO25784.1 - 4.7e-15 55.5 0.2 1.1e-13 51.0 0.2 2.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 AAA_11 PF13086.6 KOO25784.1 - 2.5e-13 50.4 0.0 5.3e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO25784.1 - 7e-08 32.4 0.1 7e-08 32.4 0.1 2.5 3 0 0 3 3 2 1 AAA domain Abhydrolase_1 PF00561.20 KOO25784.1 - 1e-07 31.9 0.0 2.4e-07 30.7 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold AAA_19 PF13245.6 KOO25784.1 - 1.5e-06 28.6 0.4 1.1e-05 25.8 0.0 2.5 3 1 0 3 3 3 1 AAA domain WW PF00397.26 KOO25784.1 - 4.6e-06 26.6 0.1 9.1e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 WW domain Abhydrolase_5 PF12695.7 KOO25784.1 - 0.00047 20.0 0.1 0.045 13.5 0.1 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF2075 PF09848.9 KOO25784.1 - 0.00073 18.9 0.6 0.3 10.3 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Esterase PF00756.20 KOO25784.1 - 0.001 18.8 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 KOO25784.1 - 0.0019 18.1 2.4 0.044 13.6 0.1 3.1 3 0 0 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOO25784.1 - 0.0031 17.0 0.0 0.027 13.9 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Ndr PF03096.14 KOO25784.1 - 0.0043 15.8 0.0 0.0079 14.9 0.0 1.3 1 0 0 1 1 1 1 Ndr family AAA_33 PF13671.6 KOO25784.1 - 0.0076 16.4 3.3 0.16 12.1 0.0 3.2 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 KOO25784.1 - 0.013 15.4 0.1 0.038 13.9 0.1 1.8 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 KOO25784.1 - 0.016 15.6 0.0 0.016 15.6 0.0 4.0 4 1 0 4 4 2 0 AAA ATPase domain AAA_22 PF13401.6 KOO25784.1 - 0.024 14.9 1.8 0.39 11.0 0.0 3.2 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 KOO25784.1 - 0.032 13.6 0.0 0.069 12.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOO25784.1 - 0.044 13.8 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PhoH PF02562.16 KOO25784.1 - 0.062 12.7 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA PF00004.29 KOO25784.1 - 0.11 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DnaJ PF00226.31 KOO25786.1 - 0.0015 18.6 0.0 0.0031 17.6 0.0 1.7 1 1 0 1 1 1 1 DnaJ domain Casc1_N PF15927.5 KOO25786.1 - 0.78 9.4 7.9 0.27 10.9 4.7 1.7 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus DUF3306 PF11748.8 KOO25786.1 - 3.2 8.7 13.5 0.29 12.0 8.7 1.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3306) MIT PF04212.18 KOO25787.1 - 7.1e-16 58.0 1.8 8.8e-16 57.7 1.8 1.1 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_2 PF07719.17 KOO25787.1 - 0.02 15.0 1.1 0.045 13.9 0.4 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat Aida_N PF08910.10 KOO25787.1 - 0.028 14.8 0.1 0.041 14.3 0.1 1.3 1 1 0 1 1 1 0 Aida N-terminus NRBF2_MIT PF17169.4 KOO25787.1 - 0.063 13.5 0.0 0.082 13.1 0.0 1.2 1 0 0 1 1 1 0 MIT domain of nuclear receptor-binding factor 2 Mu-like_gpT PF10124.9 KOO25787.1 - 0.077 12.3 0.0 0.091 12.1 0.0 1.1 1 0 0 1 1 1 0 Mu-like prophage major head subunit gpT Ribosomal_L21p PF00829.21 KOO25788.1 - 2.4e-32 111.2 0.0 3.1e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Laminin_G_3 PF13385.6 KOO25789.1 - 8.5e-32 110.4 0.0 1.1e-15 58.1 0.0 2.3 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 KOO25789.1 - 1.2e-08 35.6 0.1 0.00018 22.0 0.0 2.7 3 0 0 3 3 3 2 Laminin G domain Pentaxin PF00354.17 KOO25789.1 - 0.0032 17.2 0.0 1 9.0 0.0 2.2 2 0 0 2 2 2 2 Pentaxin family Sialidase PF02973.16 KOO25789.1 - 0.11 12.0 0.0 0.4 10.1 0.0 1.8 2 0 0 2 2 2 0 Sialidase, N-terminal domain DUF402 PF04167.13 KOO25789.1 - 0.14 12.4 0.0 6.4 7.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF402) DUF1690 PF07956.11 KOO25789.1 - 0.17 12.3 0.1 0.34 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Pkinase PF00069.25 KOO25790.1 - 3.2e-57 193.9 0.0 4.5e-57 193.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25790.1 - 9.6e-30 103.7 0.0 2.5e-29 102.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO25790.1 - 2.2e-06 27.8 0.2 0.0042 17.0 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO25790.1 - 0.0037 16.1 0.0 0.0057 15.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 KOO25790.1 - 0.0068 16.0 0.1 0.024 14.2 0.0 1.9 2 0 0 2 2 2 1 RIO1 family Kinase-like PF14531.6 KOO25790.1 - 0.013 14.9 0.0 0.025 13.9 0.0 1.5 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 KOO25790.1 - 0.03 13.3 0.4 0.13 11.1 0.1 1.9 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 KOO25790.1 - 0.05 13.0 0.0 0.087 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FlgN PF05130.12 KOO25791.1 - 0.2 12.2 6.4 0.42 11.1 6.4 1.5 1 0 0 1 1 1 0 FlgN protein DUF1843 PF08898.10 KOO25791.1 - 0.35 11.4 0.2 0.35 11.4 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) OmpH PF03938.14 KOO25791.1 - 2.2 8.6 6.3 4.8 7.5 6.3 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) MFS_1 PF07690.16 KOO25792.1 - 6e-08 32.0 37.0 3.5e-07 29.5 13.8 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 KOO25792.1 - 0.00033 20.4 6.9 0.0011 18.7 6.9 1.9 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 DUF962 PF06127.11 KOO25792.1 - 0.18 11.9 0.7 1.6 8.9 0.1 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF962) TMEM119 PF15724.5 KOO25792.1 - 1.5 8.8 11.5 0.35 10.9 1.8 2.2 2 0 0 2 2 2 0 TMEM119 family PRIMA1 PF16101.5 KOO25792.1 - 1.9 8.5 6.6 3.2 7.8 1.6 2.6 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 KOO25792.1 - 2 7.8 5.8 2.8 7.4 0.5 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal SBBP PF06739.11 KOO25793.1 - 5.4e-05 23.1 18.6 0.0028 17.6 3.7 3.5 3 0 0 3 3 3 2 Beta-propeller repeat DUF3767 PF12597.8 KOO25793.1 - 2.6 7.9 5.6 20 5.0 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3767) SAP PF02037.27 KOO25794.1 - 2.9e-15 55.6 0.8 3.1e-15 55.5 0.8 1.0 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 KOO25794.1 - 0.0002 21.0 0.1 0.00047 19.8 0.1 1.6 1 1 0 1 1 1 1 HeH/LEM domain Telomere_Sde2_2 PF13297.6 KOO25794.1 - 0.046 13.4 0.3 0.049 13.3 0.3 1.1 1 0 0 1 1 1 0 Telomere stability C-terminal FANC_SAP PF18081.1 KOO25794.1 - 0.052 13.7 1.1 0.052 13.7 1.1 1.0 1 0 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain Endonuc-dimeris PF09124.10 KOO25794.1 - 0.14 12.4 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation HA2 PF04408.23 KOO25795.1 - 8.9e-20 71.0 0.4 8.9e-20 71.0 0.4 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KOO25795.1 - 5.1e-12 46.1 0.0 9.2e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO25795.1 - 0.00024 20.9 0.0 0.00053 19.8 0.0 1.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase ATPase PF06745.13 KOO25795.1 - 0.019 14.3 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 KOO25795.1 - 0.026 14.8 0.8 0.069 13.4 0.1 2.1 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 KOO25796.1 - 1.2e-61 208.5 0.0 1.3e-61 208.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25796.1 - 1.3e-31 109.8 0.0 1.7e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO25796.1 - 0.00013 21.1 0.1 0.00017 20.6 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOO25796.1 - 0.0031 16.9 0.1 0.0047 16.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO25796.1 - 0.0065 15.8 0.0 0.0087 15.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KOO25796.1 - 0.0093 15.6 0.1 0.014 15.0 0.1 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KOO25796.1 - 0.074 13.0 0.9 0.2 11.5 0.7 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Myb_DNA-binding PF00249.31 KOO25797.1 - 4.8e-08 33.1 0.0 8.8e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_CC_LHEQLE PF14379.6 KOO25797.1 - 0.0001 21.9 11.5 0.0001 21.9 11.5 3.1 2 1 1 3 3 3 1 MYB-CC type transfactor, LHEQLE motif DUF481 PF04338.12 KOO25797.1 - 0.032 14.3 0.2 0.061 13.3 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF481 NOA36 PF06524.12 KOO25797.1 - 0.034 13.5 5.6 0.055 12.8 5.6 1.4 1 0 0 1 1 1 0 NOA36 protein AMP-binding_C_2 PF14535.6 KOO25797.1 - 0.37 11.1 1.7 0.96 9.8 1.6 1.7 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain Cwf_Cwc_15 PF04889.12 KOO25797.1 - 0.85 9.3 15.1 1.4 8.5 15.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 KOO25797.1 - 1.5 9.3 6.7 3 8.3 6.7 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PTE PF02126.18 KOO25798.1 - 4.5e-22 78.9 0.0 5.8e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotriesterase family VATC PF18716.1 KOO25798.1 - 1.6e-19 69.4 2.6 2.4e-19 68.9 2.6 1.3 1 0 0 1 1 1 1 Vms1-associating treble clef domain DUF3873 PF12989.7 KOO25799.1 - 0.09 13.2 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) Borrelia_P83 PF05262.11 KOO25799.1 - 2.9 6.3 14.2 4.2 5.7 14.2 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF2052 PF09747.9 KOO25799.1 - 3.8 7.6 11.3 0.98 9.5 7.9 1.6 1 1 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) EF-hand_7 PF13499.6 KOO25800.1 - 1.6e-18 66.9 4.8 0.051 14.0 0.0 7.3 7 0 0 7 7 7 6 EF-hand domain pair EF-hand_8 PF13833.6 KOO25800.1 - 6.4e-18 64.3 4.7 5e-05 23.1 0.1 9.1 9 1 1 10 10 10 4 EF-hand domain pair EF-hand_1 PF00036.32 KOO25800.1 - 2.7e-13 48.4 6.8 0.0057 16.1 0.0 6.7 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.6 KOO25800.1 - 7e-13 47.4 11.7 0.007 16.2 0.0 6.8 7 0 0 7 7 7 3 EF-hand domain DUF4646 PF15496.6 KOO25800.1 - 0.019 15.6 0.0 10 6.7 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4646) DUF5580 PF17743.1 KOO25800.1 - 0.04 12.5 0.0 0.084 11.4 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EF-hand_5 PF13202.6 KOO25800.1 - 0.63 9.6 8.1 9.4 5.9 0.0 3.9 3 0 0 3 3 3 0 EF hand Agenet PF05641.12 KOO25801.1 - 0.003 18.0 0.1 0.0047 17.4 0.1 1.3 1 0 0 1 1 1 1 Agenet domain TUDOR_5 PF18359.1 KOO25801.1 - 0.039 13.6 0.0 0.082 12.6 0.0 1.6 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain 1 NAD_binding_10 PF13460.6 KOO25802.1 - 3.4e-05 23.8 0.0 6.2e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO25802.1 - 0.00013 21.6 0.0 0.00016 21.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family DUF111 PF01969.17 KOO25803.1 - 0.24 10.5 0.0 0.33 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF111 2OG-FeII_Oxy_3 PF13640.6 KOO25804.1 - 9e-10 39.3 0.0 1.6e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 KOO25804.1 - 0.055 13.0 0.0 0.099 12.2 0.0 1.4 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA ABC_tran PF00005.27 KOO25805.1 - 1.1e-44 152.2 0.0 1.1e-23 84.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KOO25805.1 - 2.8e-42 145.2 18.4 4.1e-24 85.7 2.8 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 KOO25805.1 - 7.8e-06 25.9 4.8 1.8 8.3 0.1 4.2 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KOO25805.1 - 0.00012 22.0 1.1 0.35 10.8 0.3 2.9 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 KOO25805.1 - 0.00015 21.5 1.8 0.2 11.4 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 KOO25805.1 - 0.00059 19.3 3.1 0.25 10.8 0.0 3.5 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO25805.1 - 0.001 19.4 7.8 0.096 13.1 0.1 3.7 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 KOO25805.1 - 0.0063 16.6 1.3 0.58 10.3 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KOO25805.1 - 0.0065 16.7 2.4 0.78 10.0 0.1 3.1 2 1 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 KOO25805.1 - 0.022 14.8 4.0 0.33 11.0 0.4 2.3 2 0 0 2 2 2 0 Dynamin family AAA_7 PF12775.7 KOO25805.1 - 0.15 11.6 0.9 1 8.9 0.2 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF815 PF05673.13 KOO25805.1 - 0.53 9.4 1.5 5 6.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Amino_oxidase PF01593.24 KOO25806.1 - 1.2e-63 216.0 5.1 1.3e-62 212.6 5.1 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO25806.1 - 3.3e-07 30.4 0.6 1e-06 28.9 0.6 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOO25806.1 - 8.5e-07 29.1 1.5 0.00015 21.8 0.2 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.17 KOO25806.1 - 0.002 17.4 0.5 0.0039 16.5 0.5 1.4 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 KOO25806.1 - 0.055 12.8 0.4 0.092 12.0 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KOO25806.1 - 0.076 11.7 0.3 1.9 7.1 0.4 2.2 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_2 PF07992.14 KOO25806.1 - 0.11 11.7 1.8 1 8.5 0.4 2.5 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO25806.1 - 0.21 11.1 7.6 0.61 9.6 7.6 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KOO25806.1 - 0.29 10.4 2.0 12 5.0 0.1 2.5 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF2070 PF09843.9 KOO25809.1 - 0.063 11.6 1.3 0.077 11.3 1.3 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF3302 PF11742.8 KOO25809.1 - 0.25 11.5 0.1 0.25 11.5 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3302) BPD_transp_2 PF02653.16 KOO25809.1 - 0.66 9.1 9.2 0.92 8.6 8.3 1.6 1 1 1 2 2 2 0 Branched-chain amino acid transport system / permease component cNMP_binding PF00027.29 KOO25810.1 - 1.4e-06 28.3 0.0 2.6e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PAP_fibrillin PF04755.12 KOO25811.1 - 0.00014 21.9 0.1 0.0098 15.8 0.0 2.1 2 0 0 2 2 2 2 PAP_fibrillin LRR_4 PF12799.7 KOO25812.1 - 3.1e-09 37.0 0.4 0.00045 20.6 0.0 3.7 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO25812.1 - 4.9e-08 32.6 1.2 0.00012 21.8 0.1 3.0 1 1 2 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 KOO25812.1 - 4.3e-07 29.6 0.0 9.2e-07 28.5 0.0 1.5 1 1 1 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.33 KOO25812.1 - 0.097 13.3 6.5 18 6.4 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich Repeat Dopey_N PF04118.14 KOO25813.1 - 2.7e-58 197.5 0.0 1.9e-51 175.1 0.0 2.2 2 0 0 2 2 2 2 Dopey, N-terminal Ion_trans PF00520.31 KOO25813.1 - 1.2e-23 83.6 4.3 2e-23 82.9 4.3 1.2 1 0 0 1 1 1 1 Ion transport protein Methyltransf_25 PF13649.6 KOO25813.1 - 1.8e-18 67.0 0.0 4.3e-18 65.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO25813.1 - 4.2e-16 59.4 0.0 9.6e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ion_trans_2 PF07885.16 KOO25813.1 - 9.9e-12 44.7 1.2 2.1e-11 43.6 1.2 1.5 1 0 0 1 1 1 1 Ion channel Methyltransf_12 PF08242.12 KOO25813.1 - 6.7e-10 39.6 0.0 1.4e-09 38.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO25813.1 - 2.9e-09 37.0 0.0 5.5e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO25813.1 - 8.7e-09 35.3 0.0 1.6e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO25813.1 - 3.6e-08 33.0 0.0 6.4e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 KOO25813.1 - 0.00021 21.1 0.0 0.00036 20.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Lig_chan PF00060.26 KOO25813.1 - 0.0078 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel MTS PF05175.14 KOO25813.1 - 0.035 13.6 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_16 PF10294.9 KOO25813.1 - 0.09 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_29 PF03141.16 KOO25813.1 - 0.28 9.7 0.0 0.45 9.0 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase zf-FLZ PF04570.14 KOO25816.1 - 6.7e-06 25.5 0.4 9.5e-06 25.0 0.4 1.2 1 0 0 1 1 1 1 zinc-finger of the FCS-type, C2-C2 Ecl1 PF12855.7 KOO25816.1 - 0.59 11.3 4.9 0.21 12.8 0.9 2.1 2 1 0 2 2 2 0 ECL1/2/3 zinc binding proteins WD40 PF00400.32 KOO25817.1 - 2.3e-06 28.2 4.3 0.45 11.5 0.0 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat BCIP PF13862.6 KOO25818.1 - 1e-29 103.8 0.0 1.3e-29 103.4 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein CDK2AP PF09806.9 KOO25818.1 - 0.064 13.3 0.5 0.095 12.7 0.5 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Methyltransf_21 PF05050.12 KOO25819.1 - 1.3e-05 25.2 0.0 2.2e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase FkbM domain NUDIX PF00293.28 KOO25820.1 - 1.2e-05 25.4 0.4 2.2e-05 24.5 0.4 1.4 1 1 0 1 1 1 1 NUDIX domain RPEL PF02755.15 KOO25821.1 - 7.3e-05 22.3 0.5 0.52 10.1 0.9 2.4 2 0 0 2 2 2 2 RPEL repeat Rep_fac-A_C PF08646.10 KOO25823.1 - 0.0075 16.0 0.3 0.012 15.4 0.3 1.3 1 0 0 1 1 1 1 Replication factor-A C terminal domain GP120 PF00516.18 KOO25823.1 - 0.019 13.6 0.4 0.025 13.2 0.4 1.1 1 0 0 1 1 1 0 Envelope glycoprotein GP120 Mg_trans_NIPA PF05653.14 KOO25825.1 - 2.2e-13 50.0 2.8 3.3e-10 39.6 0.1 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EF-hand_1 PF00036.32 KOO25825.1 - 0.00029 20.2 0.0 0.00054 19.3 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO25825.1 - 0.00062 19.1 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO25825.1 - 0.018 15.5 0.0 0.031 14.7 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO25825.1 - 0.044 13.7 0.0 0.095 12.7 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain C2 PF00168.30 KOO25826.1 - 9.3e-16 58.0 0.0 1.9e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain Utp12 PF04003.12 KOO25827.1 - 0.011 16.1 3.0 0.2 12.0 0.1 2.6 3 0 0 3 3 3 0 Dip2/Utp12 Family Exonuc_VII_L PF02601.15 KOO25827.1 - 0.029 13.9 5.0 0.042 13.4 5.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit HGD-D PF06050.13 KOO25827.1 - 0.22 11.2 1.2 0.33 10.6 1.2 1.3 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Gluconate_2-dh3 PF13618.6 KOO25827.1 - 0.88 9.8 3.6 1.9 8.7 3.6 1.8 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 LRR_6 PF13516.6 KOO25828.1 - 3e-14 51.8 26.8 2.9e-05 23.7 0.0 9.1 10 0 0 10 10 10 4 Leucine Rich repeat EF-hand_1 PF00036.32 KOO25828.1 - 1.2e-11 43.2 2.4 1.4e-06 27.4 0.4 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO25828.1 - 1.2e-08 35.2 0.1 2.2e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO25828.1 - 2.5e-08 33.2 0.2 0.0038 17.0 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain SAM_1 PF00536.30 KOO25828.1 - 9.5e-08 32.4 0.0 1.9e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EF-hand_5 PF13202.6 KOO25828.1 - 5.6e-07 28.8 0.2 0.0017 17.8 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO25828.1 - 5.9e-07 29.2 2.9 7.7e-06 25.7 0.1 2.6 1 1 1 2 2 2 1 EF-hand domain pair SAM_2 PF07647.17 KOO25828.1 - 7.1e-06 26.0 0.0 2e-05 24.6 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) EF-hand_9 PF14658.6 KOO25828.1 - 0.00014 22.1 0.1 0.00035 20.8 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain LRR_4 PF12799.7 KOO25828.1 - 0.00036 20.9 4.0 48 4.6 0.0 6.5 7 0 0 7 7 7 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO25828.1 - 0.0024 18.2 3.6 68 4.6 0.2 6.2 7 0 0 7 7 5 0 Leucine Rich Repeat EF-hand_4 PF12763.7 KOO25828.1 - 0.12 12.3 0.5 0.25 11.3 0.1 1.7 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 KOO25828.1 - 0.23 11.5 0.0 0.44 10.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) Trimer_CC PF08954.11 KOO25829.1 - 5.2 6.7 11.5 5.4 6.6 0.2 4.7 5 0 0 5 5 5 0 Trimerisation motif HMG_box PF00505.19 KOO25830.1 - 1.3e-19 70.4 4.3 5.3e-12 46.0 0.6 2.7 2 1 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO25830.1 - 7.5e-14 52.1 4.6 4.5e-09 36.8 0.6 2.2 2 0 0 2 2 2 2 HMG-box domain C1ORF64 PF15547.6 KOO25830.1 - 0.0031 18.0 0.3 0.26 11.8 0.1 2.3 1 1 1 2 2 2 1 Steroid receptor-associated and regulated protein Macro PF01661.21 KOO25830.1 - 0.018 15.1 0.0 0.047 13.7 0.0 1.6 2 0 0 2 2 2 0 Macro domain DUF3106 PF11304.8 KOO25830.1 - 0.048 14.1 0.3 4.6 7.8 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) LTV PF04180.14 KOO25831.1 - 6e-17 62.5 0.0 1.8e-16 60.9 0.0 1.6 2 0 0 2 2 2 1 Low temperature viability protein GSHPx PF00255.19 KOO25831.1 - 2.3e-05 23.9 0.0 4.4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione peroxidase GST_C_3 PF14497.6 KOO25833.1 - 9e-09 35.4 0.0 1.4e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DHHC PF01529.20 KOO25834.1 - 2.7e-36 124.6 12.5 2.7e-36 124.6 12.5 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF588 PF04535.12 KOO25834.1 - 0.00078 19.2 2.5 0.002 17.9 2.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF588) YrhC PF14143.6 KOO25834.1 - 3.3 7.9 6.1 1.4 9.1 2.2 2.2 2 0 0 2 2 2 0 YrhC-like protein RRM_1 PF00076.22 KOO25835.1 - 1.3e-14 53.8 0.1 3.9e-14 52.2 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Paramyxo_ncap PF00973.19 KOO25835.1 - 4.9 5.9 7.2 2 7.2 1.0 2.1 2 0 0 2 2 2 0 Paramyxovirus nucleocapsid protein Ras PF00071.22 KOO25836.1 - 3.9e-19 68.8 0.0 4.5e-19 68.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO25836.1 - 7.3e-09 35.9 0.0 8.3e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO25836.1 - 0.0016 17.9 0.0 0.0018 17.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 KOO25836.1 - 0.025 14.1 0.0 0.028 13.9 0.0 1.1 1 0 0 1 1 1 0 P-loop containing dynein motor region DAP3 PF10236.9 KOO25836.1 - 0.061 12.5 0.0 0.068 12.3 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 WD40 PF00400.32 KOO25837.1 - 1.9e-10 41.1 4.5 0.00033 21.4 0.0 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat Pkinase PF00069.25 KOO25839.1 - 1.4e-30 106.6 0.0 2.1e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO25839.1 - 7.5e-27 94.2 0.0 1.1e-26 93.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 KOO25839.1 - 1.5e-18 67.1 0.0 1.5e-08 35.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO25839.1 - 1.3e-16 60.7 0.4 1.6e-07 31.7 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO25839.1 - 9.3e-13 48.1 0.7 1.2e-09 38.2 0.2 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO25839.1 - 1.2e-12 47.7 0.0 0.00097 19.5 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat zf-C3HC4_3 PF13920.6 KOO25839.1 - 7.7e-12 44.9 8.4 1.3e-11 44.2 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_3 PF13606.6 KOO25839.1 - 5e-08 32.6 0.0 0.0025 18.1 0.0 4.1 4 0 0 4 4 4 1 Ankyrin repeat Prok-RING_4 PF14447.6 KOO25839.1 - 0.00017 21.4 6.9 0.00036 20.3 6.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOO25839.1 - 0.00023 21.4 8.8 0.00051 20.3 8.8 1.6 1 0 0 1 1 1 1 Ring finger domain Pkinase_fungal PF17667.1 KOO25839.1 - 0.0019 17.1 0.1 0.0061 15.4 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase zf-C3HC4_2 PF13923.6 KOO25839.1 - 0.006 16.4 7.8 0.013 15.3 7.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) APH PF01636.23 KOO25839.1 - 0.016 15.1 19.7 0.0062 16.5 13.1 2.5 2 1 0 2 2 2 0 Phosphotransferase enzyme family zf-MIZ PF02891.20 KOO25839.1 - 0.23 11.2 5.1 0.42 10.4 5.1 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_5 PF14634.6 KOO25839.1 - 0.34 10.9 8.7 0.67 10.0 8.7 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Rieske PF00355.26 KOO25840.1 - 4.7e-06 26.5 0.0 9.1e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain DUF2177 PF09945.9 KOO25841.1 - 0.042 14.0 2.1 0.09 12.9 2.1 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2177) FA_hydroxylase PF04116.13 KOO25842.1 - 6.6e-22 78.3 19.5 6.6e-22 78.3 19.5 2.2 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily Thioredoxin_8 PF13905.6 KOO25843.1 - 6e-23 81.0 0.0 8.1e-23 80.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 KOO25843.1 - 3.8e-11 42.9 0.0 5.5e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KOO25843.1 - 2e-08 34.2 0.0 2.6e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.6 KOO25843.1 - 7.4e-06 25.8 0.0 0.0026 17.5 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin PF00085.20 KOO25843.1 - 6e-05 23.0 0.0 0.00015 21.7 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin SCO1-SenC PF02630.14 KOO25843.1 - 0.00021 21.2 0.0 0.00025 20.9 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_7 PF13899.6 KOO25843.1 - 0.0015 18.7 0.0 0.0087 16.2 0.1 2.1 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 KOO25843.1 - 0.0091 16.4 0.1 0.018 15.4 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 KOO25843.1 - 0.013 15.3 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Glutaredoxin PF00462.24 KOO25843.1 - 0.15 12.3 0.1 0.64 10.3 0.0 2.0 2 1 0 2 2 2 0 Glutaredoxin DUF929 PF06053.11 KOO25843.1 - 0.24 10.7 0.0 0.33 10.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) Arm PF00514.23 KOO25844.1 - 6.2e-33 111.8 30.2 1.3e-07 31.4 0.2 13.7 13 0 0 13 13 13 10 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO25844.1 - 1.4e-06 28.2 0.0 0.24 11.5 0.0 5.3 7 0 0 7 7 7 3 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 KOO25844.1 - 0.00086 19.8 0.9 0.00086 19.8 0.9 10.0 8 2 3 11 11 11 4 HEAT-like repeat HEAT_2 PF13646.6 KOO25844.1 - 7.7 7.0 49.2 0.056 13.8 1.0 7.1 6 3 0 6 6 6 0 HEAT repeats Peptidase_C2 PF00648.21 KOO25845.1 - 2.1e-75 253.5 0.0 2.9e-75 253.0 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease EF-hand_1 PF00036.32 KOO25847.1 - 3.9e-07 29.1 0.7 0.0015 17.9 0.1 4.2 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.6 KOO25847.1 - 1.5e-06 27.7 0.0 0.17 11.9 0.0 4.3 5 0 0 5 5 5 2 EF-hand domain EF-hand_7 PF13499.6 KOO25847.1 - 1e-05 25.9 0.6 0.058 13.8 0.0 3.1 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO25847.1 - 0.00044 19.6 1.5 0.18 11.3 0.1 4.0 4 0 0 4 4 4 1 EF hand Chon_Sulph_att PF06566.11 KOO25847.1 - 0.11 12.3 2.0 0.096 12.5 0.4 1.5 1 1 0 1 1 1 0 Chondroitin sulphate attachment domain EF-hand_8 PF13833.6 KOO25847.1 - 0.14 12.1 0.9 0.5 10.3 0.2 2.1 2 0 0 2 2 2 0 EF-hand domain pair DNA_pol_B PF00136.21 KOO25848.1 - 1.9e-53 181.8 0.0 5.4e-53 180.3 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KOO25848.1 - 2.8e-07 30.0 0.0 0.019 14.1 0.0 3.4 4 0 0 4 4 4 2 DNA polymerase family B, exonuclease domain HAP1_N PF04849.13 KOO25848.1 - 0.14 11.3 1.6 0.3 10.2 0.5 2.0 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Na_H_Exchanger PF00999.21 KOO25849.1 - 5.8e-55 186.6 27.6 7.9e-55 186.2 27.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FKBP_C PF00254.28 KOO25850.1 - 2.5e-31 107.8 0.0 4e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PepSY_2 PF13670.6 KOO25850.1 - 9 6.4 5.9 53 3.9 5.9 2.2 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain Methyltransf_21 PF05050.12 KOO25851.1 - 0.0014 18.7 0.0 0.0022 18.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase FkbM domain AMP-binding PF00501.28 KOO25852.1 - 3.9e-42 144.3 0.4 7.2e-42 143.4 0.4 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_10 PF13460.6 KOO25852.1 - 0.045 13.6 0.2 0.085 12.7 0.2 1.5 1 0 0 1 1 1 0 NAD(P)H-binding MGS PF02142.22 KOO25852.1 - 0.089 13.0 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 MGS-like domain DUF4350 PF14258.6 KOO25852.1 - 0.13 12.7 0.3 36 4.9 0.0 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4350) Ank_2 PF12796.7 KOO25853.1 - 1.3e-30 105.8 5.0 2.6e-07 31.1 0.3 5.3 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO25853.1 - 6.5e-30 103.1 4.7 6.3e-07 29.8 0.1 6.6 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO25853.1 - 3.5e-23 81.4 12.3 3.9e-05 23.8 0.4 6.1 4 3 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO25853.1 - 1e-19 68.5 5.2 0.0091 16.4 0.0 7.8 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 KOO25853.1 - 6.7e-16 57.9 13.3 0.0047 17.3 0.0 7.9 8 0 0 8 8 8 5 Ankyrin repeat Geminin PF07412.12 KOO25853.1 - 0.13 12.0 0.4 0.48 10.1 0.1 2.0 2 0 0 2 2 2 0 Geminin Abhydrolase_4 PF08386.10 KOO25854.1 - 4.8e-05 23.4 0.0 9.7e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 KOO25854.1 - 0.015 14.9 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Vint PF14623.6 KOO25855.1 - 2.2e-10 40.6 0.0 4.4e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Hint-domain CNH PF00780.22 KOO25856.1 - 4.7e-08 33.0 0.0 8e-08 32.2 0.0 1.4 1 1 0 1 1 1 1 CNH domain Apolipoprotein PF01442.18 KOO25856.1 - 0.11 12.4 0.2 0.16 11.8 0.2 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Agenet PF05641.12 KOO25857.1 - 0.037 14.5 0.0 0.096 13.2 0.0 1.7 1 0 0 1 1 1 0 Agenet domain Tudor_2 PF18104.1 KOO25857.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain TUDOR_5 PF18359.1 KOO25857.1 - 0.15 11.8 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain 1 Methyltransf_25 PF13649.6 KOO25858.1 - 4.1e-09 37.0 0.0 3.2e-08 34.2 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 KOO25858.1 - 3e-08 33.4 0.0 4.9e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 KOO25858.1 - 1.3e-07 31.6 0.0 3.2e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO25858.1 - 2.7e-05 24.7 0.0 0.00012 22.6 0.0 2.2 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO25858.1 - 0.0003 21.5 0.0 0.0011 19.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOO25858.1 - 0.0006 19.4 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 KOO25858.1 - 0.00075 19.3 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOO25858.1 - 0.002 18.2 0.0 0.0045 17.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain AviRa PF11599.8 KOO25858.1 - 0.012 15.1 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa PRMT5 PF05185.16 KOO25858.1 - 0.04 13.8 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase NAD_binding_10 PF13460.6 KOO25859.1 - 1.8e-10 41.0 0.8 2.8e-10 40.4 0.8 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Ank_2 PF12796.7 KOO25860.1 - 5.4e-17 62.2 0.1 2.1e-10 41.0 0.1 2.8 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) FHA PF00498.26 KOO25860.1 - 1.1e-11 44.9 0.0 2.2e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 FHA domain Ank_4 PF13637.6 KOO25860.1 - 1.1e-10 41.8 0.7 0.00025 21.6 0.1 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO25860.1 - 6.7e-10 38.4 0.2 3.3e-05 24.0 0.1 4.9 5 0 0 5 5 4 1 Ankyrin repeat Ank_5 PF13857.6 KOO25860.1 - 7.7e-10 38.8 0.2 2.3e-06 27.7 0.2 3.6 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO25860.1 - 7.9e-10 38.7 0.1 0.00013 22.2 0.2 4.7 4 0 0 4 4 4 2 Ankyrin repeat Yop-YscD_cpl PF16697.5 KOO25860.1 - 0.015 15.6 0.0 0.046 14.0 0.0 1.8 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain DUF883 PF05957.13 KOO25860.1 - 0.057 14.0 0.3 0.18 12.4 0.3 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Spc7 PF08317.11 KOO25860.1 - 0.065 12.1 0.6 0.1 11.4 0.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein MPS2 PF17060.5 KOO25860.1 - 0.18 11.0 0.4 0.3 10.3 0.4 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 Syntaphilin PF15290.6 KOO25860.1 - 0.46 10.1 2.5 0.84 9.2 2.5 1.3 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp Galactosyl_T PF01762.21 KOO25861.1 - 0.2 11.5 0.0 0.39 10.5 0.0 1.6 1 1 0 1 1 1 0 Galactosyltransferase Lambda_tail_I PF06805.12 KOO25863.1 - 0.066 13.6 0.0 0.2 12.0 0.0 1.8 2 0 0 2 2 2 0 Bacteriophage lambda tail assembly protein I Cytochrome_P460 PF16694.5 KOO25864.1 - 0.079 13.3 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 Cytochrome P460 CS PF04969.16 KOO25865.1 - 1.8e-14 54.5 0.1 2.6e-14 54.0 0.1 1.3 1 0 0 1 1 1 1 CS domain Glyco_hydro2_C5 PF18565.1 KOO25867.1 - 1.3e-24 85.9 0.1 2.6e-24 85.0 0.1 1.5 1 0 0 1 1 1 1 Glycoside hydrolase family 2 C-terminal domain 5 Glyco_hydro_2_C PF02836.17 KOO25867.1 - 6.9e-16 58.2 0.0 7.2e-07 28.6 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 2, TIM barrel domain DUF4982 PF16355.5 KOO25867.1 - 7.4e-15 54.6 0.3 1.8e-14 53.4 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4982) Glyco_hydro_2_N PF02837.18 KOO25867.1 - 4e-13 49.6 0.0 1.3e-12 48.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 KOO25867.1 - 6e-05 23.7 0.0 0.00012 22.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Big_1 PF02369.16 KOO25867.1 - 0.00011 22.1 6.0 0.00064 19.7 1.3 2.7 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) Invasin_D3 PF09134.10 KOO25867.1 - 0.018 15.3 2.6 0.18 12.1 0.1 2.5 2 0 0 2 2 2 0 Invasin, domain 3 PAN_4 PF14295.6 KOO25867.1 - 0.19 11.6 17.1 0.25 11.3 14.4 2.6 2 0 0 2 2 2 0 PAN domain EF-hand_6 PF13405.6 KOO25868.1 - 4.4e-08 32.4 1.8 0.00092 19.0 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO25868.1 - 4.7e-07 29.0 2.1 0.0046 16.4 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO25868.1 - 5.5e-07 28.7 1.6 0.0061 16.0 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO25868.1 - 7.9e-06 25.6 1.5 0.00054 19.8 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO25868.1 - 8.4e-06 26.2 1.1 0.0053 17.2 0.1 2.2 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 KOO25870.1 - 6.8e-21 74.5 13.5 4.1e-09 36.8 0.6 3.8 3 0 0 3 3 3 3 EF-hand domain pair Guanylate_cyc PF00211.20 KOO25870.1 - 3.6e-20 72.3 0.0 2.6e-09 36.9 0.0 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain EF-hand_6 PF13405.6 KOO25870.1 - 8.6e-18 62.7 16.0 0.00011 21.8 0.1 6.0 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 KOO25870.1 - 1.6e-15 55.4 23.6 0.00051 19.4 0.0 5.9 7 0 0 7 7 6 4 EF hand AAA_16 PF13191.6 KOO25870.1 - 4.6e-13 49.9 0.6 1.5e-06 28.7 0.1 3.7 3 0 0 3 3 3 2 AAA ATPase domain EF-hand_5 PF13202.6 KOO25870.1 - 8.9e-09 34.5 14.8 0.15 11.6 0.0 5.7 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO25870.1 - 7.2e-08 32.2 9.4 0.0005 19.9 0.2 5.2 3 2 1 4 4 4 2 EF-hand domain pair TPR_12 PF13424.6 KOO25870.1 - 0.0018 18.5 2.1 0.0018 18.5 2.1 5.6 5 1 1 6 6 6 1 Tetratricopeptide repeat EF-hand_4 PF12763.7 KOO25870.1 - 0.0023 17.9 0.6 0.11 12.4 0.2 3.2 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand AAA_22 PF13401.6 KOO25870.1 - 0.054 13.8 0.1 0.23 11.7 0.0 2.1 2 0 0 2 2 1 0 AAA domain EF-hand_10 PF14788.6 KOO25870.1 - 0.068 13.1 1.0 1.7 8.6 0.0 3.2 3 0 0 3 3 3 0 EF hand NACHT PF05729.12 KOO25870.1 - 0.1 12.5 0.1 0.47 10.4 0.0 2.2 3 0 0 3 3 3 0 NACHT domain TPR_20 PF14561.6 KOO25870.1 - 7.1 7.0 6.0 21 5.6 0.3 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25870.1 - 9 7.0 14.9 0.26 12.0 0.1 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat EF-hand_6 PF13405.6 KOO25871.1 - 1.2e-12 46.6 0.6 0.0042 16.9 0.0 3.9 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO25871.1 - 8.2e-12 43.8 2.1 0.0013 18.1 0.0 3.9 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO25871.1 - 8.1e-10 39.0 1.6 2.8e-05 24.5 0.4 3.0 1 1 0 2 2 2 2 EF-hand domain pair WW PF00397.26 KOO25871.1 - 9e-09 35.3 5.1 2e-05 24.6 0.3 3.1 2 0 0 2 2 2 2 WW domain EF-hand_8 PF13833.6 KOO25871.1 - 1.6e-07 31.0 0.6 0.0014 18.5 0.2 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO25871.1 - 6.8e-05 22.2 16.5 0.0022 17.4 0.0 4.6 5 0 0 5 5 5 2 EF hand EF-hand_11 PF08976.11 KOO25871.1 - 0.046 14.6 0.0 0.52 11.2 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain RsgA_N PF16745.5 KOO25871.1 - 0.052 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 RsgA N-terminal domain SPARC_Ca_bdg PF10591.9 KOO25871.1 - 3.1 8.1 5.7 13 6.2 0.0 4.4 3 2 1 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region SMC_N PF02463.19 KOO25872.1 - 3.6e-25 88.7 0.0 5.8e-25 88.0 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOO25872.1 - 1.2e-12 48.8 26.4 1.2e-12 48.8 26.4 5.7 2 2 1 4 4 4 1 AAA domain AAA_15 PF13175.6 KOO25872.1 - 1e-05 25.4 0.0 1e-05 25.4 0.0 4.1 3 1 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 KOO25872.1 - 0.0022 17.7 0.0 0.0056 16.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran_CTD PF16326.5 KOO25872.1 - 0.0032 17.7 2.5 0.0032 17.7 2.5 11.2 5 3 5 10 10 10 1 ABC transporter C-terminal domain AAA_21 PF13304.6 KOO25872.1 - 0.1 12.4 0.1 0.1 12.4 0.1 2.7 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system DASH_Dam1 PF08653.10 KOO25872.1 - 3.2 7.6 7.8 0.42 10.4 0.3 3.6 4 0 0 4 4 4 0 DASH complex subunit Dam1 CBFD_NFYB_HMF PF00808.23 KOO25873.1 - 1.3e-15 57.4 0.6 1.3e-15 57.4 0.6 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOO25873.1 - 0.00027 21.3 0.7 0.00035 20.9 0.2 1.4 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 KOO25873.1 - 0.013 15.5 0.1 0.017 15.2 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit Vps5 PF09325.10 KOO25874.1 - 0.0012 18.5 3.4 0.0021 17.7 3.2 1.4 1 1 0 1 1 1 1 Vps5 C terminal like GlcNAc_2-epim PF07221.11 KOO25875.1 - 4.5e-74 249.8 15.5 5.6e-74 249.5 15.5 1.0 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) C5-epim_C PF06662.13 KOO25875.1 - 0.0011 18.4 0.6 0.0061 16.1 0.6 2.2 2 1 0 2 2 2 1 D-glucuronyl C5-epimerase C-terminus Methyltransf_24 PF13578.6 KOO25876.1 - 0.0016 19.4 0.1 0.0046 18.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain GHL13 PF14883.6 KOO25877.1 - 0.12 11.4 0.2 0.17 10.9 0.2 1.1 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 DAGK_cat PF00781.24 KOO25878.1 - 9.4e-29 99.6 0.2 1.6e-28 98.9 0.2 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain SKN1 PF03935.15 KOO25879.1 - 4.3e-57 193.7 4.9 2.1e-28 99.0 0.7 3.2 3 0 0 3 3 3 3 Beta-glucan synthesis-associated protein (SKN1) Glyco_hydro_16 PF00722.21 KOO25879.1 - 0.00013 21.5 4.8 0.017 14.6 0.0 3.2 2 1 0 2 2 2 2 Glycosyl hydrolases family 16 PGF-CTERM PF18204.1 KOO25879.1 - 1.4 9.0 3.8 2.6 8.1 3.8 1.5 1 0 0 1 1 1 0 PGF-CTERM motif cobW PF02492.19 KOO25880.1 - 8.5e-56 188.3 6.7 8e-52 175.4 1.1 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KOO25880.1 - 9e-30 102.5 0.0 1.3e-20 73.1 0.0 2.6 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 KOO25880.1 - 3.9e-05 23.6 0.6 0.22 11.4 0.1 2.9 2 0 0 2 2 2 2 RsgA GTPase TsaE PF02367.17 KOO25880.1 - 0.031 14.3 0.1 0.067 13.2 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 KOO25880.1 - 0.19 12.1 6.6 0.48 10.8 1.3 3.7 3 1 0 3 3 3 0 AAA ATPase domain ATPase_2 PF01637.18 KOO25880.1 - 0.22 11.4 0.0 0.42 10.5 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Glyco_hydro_6 PF01341.17 KOO25881.1 - 1.7e-64 218.5 0.0 3.1e-63 214.3 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 6 EF-hand_1 PF00036.32 KOO25882.1 - 4.4e-21 72.8 2.8 7.6e-05 22.0 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO25882.1 - 6.9e-20 69.2 2.5 9.6e-05 22.0 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO25882.1 - 1.5e-16 60.6 1.0 5.2e-09 36.4 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO25882.1 - 3.5e-11 42.8 0.4 0.019 14.8 0.0 4.1 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO25882.1 - 4.9e-07 29.0 9.2 0.0005 19.4 0.1 4.0 4 0 0 4 4 4 2 EF hand Toprim_Crpt PF13342.6 KOO25882.1 - 0.14 12.1 0.1 0.44 10.6 0.1 1.9 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase SPARC_Ca_bdg PF10591.9 KOO25882.1 - 0.2 12.0 0.6 0.61 10.4 0.1 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Syntaxin-18_N PF10496.9 KOO25883.1 - 2.3e-09 37.4 0.0 5.9e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 SNARE-complex protein Syntaxin-18 N-terminus DUF5320 PF17253.2 KOO25883.1 - 0.039 15.0 1.6 0.066 14.3 0.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5320) SNARE PF05739.19 KOO25883.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 SNARE domain TipAS PF07739.13 KOO25883.1 - 0.89 10.1 4.9 3.2 8.3 0.1 2.7 2 1 1 3 3 3 0 TipAS antibiotic-recognition domain Atg14 PF10186.9 KOO25883.1 - 5.7 5.9 6.2 4.4 6.3 3.1 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 KOO25883.1 - 6.5 7.1 9.2 5.8 7.3 5.3 2.3 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Acyl-CoA_dh_1 PF00441.24 KOO25884.1 - 2.2e-50 170.8 7.2 4.6e-50 169.7 7.2 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOO25884.1 - 1.1e-39 135.6 0.7 4.8e-39 133.5 0.1 2.3 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KOO25884.1 - 4e-30 103.9 0.1 9.1e-30 102.7 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KOO25884.1 - 4.1e-25 88.6 7.4 7.7e-25 87.7 7.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 KOO25884.1 - 0.0017 18.0 0.1 0.0077 15.9 0.0 1.9 2 0 0 2 2 2 1 4-hydroxyphenylacetate 3-hydroxylase N terminal DUF743 PF05332.11 KOO25884.1 - 0.17 12.0 0.9 0.29 11.2 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF743) PLU-1 PF08429.11 KOO25885.1 - 7.1e-06 25.4 0.0 9.2e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 PLU-1-like protein MSA-2c PF12238.8 KOO25886.1 - 1.6 8.7 5.0 2.4 8.1 5.0 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c PLU-1 PF08429.11 KOO25887.1 - 2.7e-37 128.7 8.4 7.8e-20 71.3 2.4 3.5 1 1 2 3 3 3 3 PLU-1-like protein PHD PF00628.29 KOO25887.1 - 1.5e-09 37.6 3.6 3.3e-09 36.5 3.6 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 KOO25887.1 - 0.015 15.6 1.0 0.047 14.0 0.1 2.1 2 0 0 2 2 2 0 PHD-like zinc-binding domain DZR PF12773.7 KOO25887.1 - 0.18 11.9 1.9 0.46 10.5 1.9 1.7 1 0 0 1 1 1 0 Double zinc ribbon HSP90 PF00183.18 KOO25888.1 - 1.5e-182 608.1 26.1 2.1e-182 607.7 26.1 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 KOO25888.1 - 4.5e-09 36.8 0.1 1.2e-08 35.5 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOO25888.1 - 1.3e-07 31.5 0.1 3.5e-07 30.1 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase VEFS-Box PF09733.9 KOO25888.1 - 8.3 6.2 7.7 4.9 7.0 0.8 2.9 2 0 0 2 2 2 0 VEFS-Box of polycomb protein zf-RanBP PF00641.18 KOO25889.1 - 1.1e-06 27.8 5.0 3e-06 26.4 5.0 1.8 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Methyltransf_16 PF10294.9 KOO25891.1 - 2.3e-17 63.3 0.0 3.6e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase EF-hand_1 PF00036.32 KOO25892.1 - 0.056 13.0 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 KOO25892.1 - 0.078 12.9 0.1 0.24 11.4 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.6 KOO25892.1 - 0.14 12.0 0.1 0.36 10.7 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair TetR_C_16 PF17920.1 KOO25892.1 - 8.8 6.6 9.6 8 6.8 0.3 4.5 3 2 2 5 5 5 0 Tetracyclin repressor-like, C-terminal domain HTH_3 PF01381.22 KOO25893.1 - 2.6e-12 46.6 0.9 7.8e-12 45.1 0.2 1.9 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 KOO25893.1 - 1.1e-05 25.7 0.0 2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 KOO25893.1 - 0.00047 20.1 0.2 0.00074 19.5 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MqsA_antitoxin PF15731.5 KOO25893.1 - 0.0037 17.3 0.1 0.0048 17.0 0.1 1.1 1 0 0 1 1 1 1 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_25 PF13413.6 KOO25893.1 - 0.02 14.7 0.1 0.037 13.9 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain MBF1 PF08523.10 KOO25893.1 - 0.043 14.3 2.0 0.8 10.2 0.0 2.9 3 0 0 3 3 3 0 Multiprotein bridging factor 1 DWNN PF08783.11 KOO25893.1 - 0.055 13.8 0.4 0.1 12.9 0.3 1.5 1 1 0 1 1 1 0 DWNN domain DUF3071 PF11268.8 KOO25893.1 - 0.062 13.4 0.1 0.063 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Ribosomal_L29 PF00831.23 KOO25893.1 - 0.59 10.1 3.5 3.3 7.8 3.5 2.1 1 1 0 1 1 1 0 Ribosomal L29 protein PLU-1 PF08429.11 KOO25894.1 - 1.7e-12 47.2 6.3 1.1e-10 41.2 1.4 2.5 3 0 0 3 3 3 2 PLU-1-like protein PHD PF00628.29 KOO25894.1 - 2.2e-07 30.6 8.3 4e-07 29.8 8.3 1.4 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.6 KOO25894.1 - 0.00085 19.0 3.4 0.039 13.6 0.5 2.3 1 1 1 2 2 2 2 PHD/FYVE-zinc-finger like domain DUF2277 PF10041.9 KOO25894.1 - 0.0026 18.1 0.1 0.035 14.4 0.1 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2277) PHD_4 PF16866.5 KOO25894.1 - 0.21 11.7 6.4 0.49 10.5 6.4 1.6 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.6 KOO25894.1 - 0.3 11.4 4.2 0.59 10.4 4.2 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain ArfGap PF01412.18 KOO25896.1 - 4.9e-32 110.4 0.0 1.1e-31 109.3 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf C2 PF00168.30 KOO25896.1 - 1.9e-19 69.9 0.0 6.9e-19 68.1 0.0 2.0 1 1 1 2 2 2 1 C2 domain HMMR_N PF15905.5 KOO25896.1 - 0.002 17.6 7.1 0.003 17.1 7.1 1.2 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal DUF4201 PF13870.6 KOO25896.1 - 0.0086 15.8 5.5 0.014 15.1 0.9 2.2 1 1 0 2 2 2 1 Domain of unknown function (DUF4201) HAP1_N PF04849.13 KOO25896.1 - 0.0099 15.1 5.0 0.026 13.8 5.0 1.6 1 1 0 1 1 1 1 HAP1 N-terminal conserved region DUF4200 PF13863.6 KOO25896.1 - 0.02 15.3 5.8 0.048 14.1 5.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Fez1 PF06818.15 KOO25896.1 - 0.031 14.7 7.3 0.06 13.8 7.3 1.5 1 0 0 1 1 1 0 Fez1 MscS_porin PF12795.7 KOO25896.1 - 0.057 13.0 13.2 0.097 12.2 13.2 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain BRE1 PF08647.11 KOO25896.1 - 0.089 12.9 4.4 0.15 12.2 3.0 2.1 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase Flagellin_C PF00700.21 KOO25896.1 - 0.094 13.1 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region Spc7 PF08317.11 KOO25896.1 - 0.13 11.2 12.7 0.083 11.8 5.1 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein Bacillus_HBL PF05791.11 KOO25896.1 - 0.15 11.8 1.1 0.51 10.1 0.1 1.9 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Atg14 PF10186.9 KOO25896.1 - 0.16 11.0 10.4 0.34 10.0 10.4 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1068 PF06364.12 KOO25896.1 - 0.17 11.8 3.1 0.5 10.2 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1068) SlyX PF04102.12 KOO25896.1 - 0.17 12.5 6.2 7.4 7.3 0.9 3.0 2 0 0 2 2 2 0 SlyX Cnn_1N PF07989.11 KOO25896.1 - 0.27 11.4 6.2 1.6 8.9 0.5 2.9 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Vps51 PF08700.11 KOO25896.1 - 0.35 11.0 2.2 0.35 11.0 0.5 1.9 2 0 0 2 2 2 0 Vps51/Vps67 TolA_bind_tri PF16331.5 KOO25896.1 - 0.42 10.7 5.9 0.17 12.0 1.5 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation Golgin_A5 PF09787.9 KOO25896.1 - 0.64 9.4 11.6 0.87 9.0 10.5 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 HIP1_clath_bdg PF16515.5 KOO25896.1 - 0.73 10.5 9.9 2.9 8.5 2.2 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4763 PF15960.5 KOO25896.1 - 0.8 9.0 6.2 0.18 11.1 2.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Kre28 PF17097.5 KOO25896.1 - 1.2 8.1 3.7 1.7 7.5 3.7 1.1 1 0 0 1 1 1 0 Spindle pole body component BST2 PF16716.5 KOO25896.1 - 1.7 9.3 10.8 7.7 7.2 0.8 2.9 1 1 1 3 3 3 0 Bone marrow stromal antigen 2 DUF4407 PF14362.6 KOO25896.1 - 3 7.1 13.8 5 6.4 13.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XhlA PF10779.9 KOO25896.1 - 3.9 7.7 6.0 1.9 8.8 1.8 2.5 2 1 1 3 3 3 0 Haemolysin XhlA Cep57_MT_bd PF06657.13 KOO25896.1 - 5.9 7.4 7.5 35 4.9 0.6 2.8 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF2203 PF09969.9 KOO25896.1 - 6 7.6 6.0 4 8.2 1.0 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Nup88 PF10168.9 KOO25896.1 - 6.3 4.5 6.3 8.6 4.0 6.3 1.1 1 0 0 1 1 1 0 Nuclear pore component Prefoldin_2 PF01920.20 KOO25896.1 - 6.7 6.7 7.1 11 6.0 1.7 2.6 2 0 0 2 2 2 0 Prefoldin subunit TMF_DNA_bd PF12329.8 KOO25896.1 - 7.8 6.6 9.9 4.6 7.3 4.0 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding UPF0242 PF06785.11 KOO25896.1 - 8.8 6.4 7.3 16 5.6 7.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Jnk-SapK_ap_N PF09744.9 KOO25896.1 - 9.6 6.4 14.4 17 5.6 8.2 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 LRR_6 PF13516.6 KOO25897.1 - 1.3e-06 27.9 19.1 0.24 11.6 0.0 6.8 8 0 0 8 8 8 4 Leucine Rich repeat LRR_4 PF12799.7 KOO25897.1 - 0.003 17.9 0.1 8.3 7.0 0.1 4.0 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO25897.1 - 0.04 14.4 0.0 14 6.7 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO25897.1 - 0.26 11.1 5.1 5.9 6.7 0.3 4.0 4 2 1 5 5 4 0 Leucine rich repeat STT3 PF02516.14 KOO25898.1 - 1.5e-65 222.0 14.1 1.5e-62 212.1 13.6 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Glyco_transf_29 PF00777.18 KOO25901.1 - 8.9e-30 104.0 0.0 2.9e-29 102.3 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Cir_N PF10197.9 KOO25902.1 - 0.00025 21.2 3.5 0.00025 21.2 3.5 2.3 2 0 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR RRM_1 PF00076.22 KOO25903.1 - 1.3e-16 60.1 0.0 0.0006 19.6 0.0 5.2 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO25903.1 - 0.0055 16.5 0.0 2.1 8.3 0.0 2.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif DbpA PF03880.15 KOO25903.1 - 0.14 12.1 0.0 1.3 9.0 0.0 2.4 3 0 0 3 3 3 0 DbpA RNA binding domain SBBP PF06739.11 KOO25904.1 - 1.6e-22 79.2 52.7 0.00084 19.3 1.7 8.1 8 0 0 8 8 8 6 Beta-propeller repeat SPOC PF07744.13 KOO25904.1 - 0.012 15.5 0.0 1e+02 2.8 0.0 5.0 1 1 4 6 6 6 0 SPOC domain A2M PF00207.22 KOO25904.1 - 0.098 12.5 3.2 44 4.0 0.0 4.1 4 0 0 4 4 4 0 Alpha-2-macroglobulin family OCIA PF07051.11 KOO25904.1 - 3.3 7.8 19.0 6.2 6.9 0.1 6.3 7 0 0 7 7 7 0 Ovarian carcinoma immunoreactive antigen (OCIA) Keratin_2_head PF16208.5 KOO25904.1 - 5 7.3 82.0 6.2 6.9 9.1 6.6 1 1 6 7 7 7 0 Keratin type II head Choline_transpo PF04515.12 KOO25905.1 - 6e-29 101.3 3.4 6e-29 101.3 3.4 3.0 2 1 1 3 3 3 2 Plasma-membrane choline transporter adh_short PF00106.25 KOO25905.1 - 3.6e-23 82.0 0.0 7.1e-23 81.1 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO25905.1 - 1.7e-15 57.3 0.0 3.2e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase EF-hand_6 PF13405.6 KOO25906.1 - 5.8e-16 57.0 0.0 5.4e-05 22.8 0.0 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO25906.1 - 2.6e-15 54.7 0.1 9.7e-06 24.8 0.0 3.6 3 0 0 3 3 3 3 EF hand Thioredoxin PF00085.20 KOO25906.1 - 4.6e-15 55.5 0.0 9.9e-15 54.4 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin EF-hand_5 PF13202.6 KOO25906.1 - 9.8e-13 47.0 0.5 0.0032 16.9 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO25906.1 - 5.8e-12 45.9 0.3 0.00023 21.5 0.3 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO25906.1 - 2.1e-10 40.3 2.0 0.0015 18.3 0.0 3.8 4 0 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO25906.1 - 0.0017 18.7 0.0 0.47 10.8 0.0 3.1 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region OST3_OST6 PF04756.13 KOO25906.1 - 0.0088 15.4 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family EF-hand_4 PF12763.7 KOO25906.1 - 0.098 12.6 0.3 12 5.9 0.0 2.7 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand G8 PF10162.9 KOO25907.1 - 6.8e-20 71.4 0.0 1.5e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 G8 domain Beta_helix PF13229.6 KOO25907.1 - 8.3e-05 22.5 4.0 0.00075 19.4 2.1 2.9 2 1 0 2 2 2 1 Right handed beta helix region SPDY PF03771.16 KOO25907.1 - 0.012 15.5 1.2 7.6 6.5 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF317) Amnionless PF14828.6 KOO25907.1 - 0.015 14.2 0.0 0.022 13.6 0.0 1.2 1 0 0 1 1 1 0 Amnionless Nucleotid_trans PF03407.16 KOO25908.1 - 4e-34 118.5 0.0 5.6e-34 118.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase RmlD_sub_bind PF04321.17 KOO25909.1 - 2.8e-30 105.4 0.0 4.1e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 KOO25909.1 - 2.4e-21 76.3 0.0 3.3e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO25909.1 - 8.4e-13 48.4 0.0 1.1e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF218 PF02698.17 KOO25909.1 - 1.5e-08 34.8 0.2 3.4e-08 33.6 0.2 1.6 1 0 0 1 1 1 1 DUF218 domain 3Beta_HSD PF01073.19 KOO25909.1 - 1.9e-05 23.8 0.0 2.7e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KOO25909.1 - 5.2e-05 22.5 0.1 0.00018 20.8 0.1 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 KOO25909.1 - 0.00024 20.3 0.0 0.3 10.2 0.0 2.5 1 1 0 2 2 2 2 Male sterility protein DapB_N PF01113.20 KOO25909.1 - 0.015 15.4 0.1 0.027 14.6 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_10 PF13460.6 KOO25909.1 - 0.045 13.6 1.1 0.16 11.8 0.4 2.1 2 0 0 2 2 2 0 NAD(P)H-binding Semialdhyde_dh PF01118.24 KOO25909.1 - 0.047 14.1 0.1 0.094 13.2 0.1 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain UQ_con PF00179.26 KOO25910.1 - 3.1e-51 172.7 0.0 3.5e-51 172.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOO25910.1 - 0.0002 21.6 0.0 0.00034 20.9 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 KOO25910.1 - 0.0012 18.6 0.0 0.0014 18.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KOO25910.1 - 0.058 13.3 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 UEV domain Hydrolase_3 PF08282.12 KOO25912.1 - 2.3e-44 152.1 0.0 3.1e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KOO25912.1 - 1.9e-09 37.4 0.0 3.4e-06 26.8 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.7 KOO25912.1 - 8.5e-08 32.8 0.0 0.011 16.2 0.0 2.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO25912.1 - 2.2e-06 28.1 0.5 0.0053 17.1 0.2 2.4 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase DNA_photolyase PF00875.18 KOO25912.1 - 0.031 14.3 0.0 0.14 12.2 0.0 2.0 2 0 0 2 2 2 0 DNA photolyase Myb_DNA-binding PF00249.31 KOO25913.1 - 0.00022 21.4 0.0 0.00052 20.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 KOO25914.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain NMT1_3 PF16868.5 KOO25916.1 - 0.00077 19.0 1.1 0.0013 18.2 1.1 1.6 1 0 0 1 1 1 1 NMT1-like family MapZ_EC1 PF18041.1 KOO25916.1 - 0.098 12.9 11.6 6.6 7.0 0.5 4.1 1 1 3 4 4 4 0 MapZ extracellular domain 1 Vps4_C PF09336.10 KOO25916.1 - 0.6 10.2 3.8 20 5.3 0.4 3.0 1 1 0 2 2 2 0 Vps4 C terminal oligomerisation domain Shisa PF13908.6 KOO25917.1 - 2.2e-05 24.8 0.0 2.2e-05 24.8 0.0 2.5 3 0 0 3 3 3 1 Wnt and FGF inhibitory regulator PA26 PF04636.13 KOO25917.1 - 0.0057 15.6 1.0 0.0057 15.6 1.0 2.1 1 1 1 2 2 2 1 PA26 p53-induced protein (sestrin) MMM1 PF10296.9 KOO25917.1 - 0.077 12.0 0.7 0.14 11.2 0.0 1.7 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 AhpC-TSA PF00578.21 KOO25917.1 - 0.12 12.3 0.1 0.55 10.1 0.0 2.1 2 0 0 2 2 2 0 AhpC/TSA family FAM163 PF15069.6 KOO25917.1 - 0.22 11.9 5.6 0.22 11.9 3.8 2.0 1 1 0 1 1 1 0 FAM163 family MAT1 PF06391.13 KOO25917.1 - 0.64 9.8 12.7 0.51 10.1 1.8 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Syntaxin PF00804.25 KOO25917.1 - 2.6 7.7 16.9 0.18 11.5 4.8 2.2 2 0 0 2 2 2 0 Syntaxin EMC3_TMCO1 PF01956.16 KOO25917.1 - 6.8 6.4 4.9 19 4.9 2.1 2.3 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Prominin PF05478.11 KOO25917.1 - 8.7 4.2 11.2 0.54 8.2 1.8 2.1 2 0 0 2 2 2 0 Prominin DUF1295 PF06966.12 KOO25919.1 - 3e-39 134.9 1.8 5.4e-39 134.1 1.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF2615 PF11027.8 KOO25919.1 - 6.6e-08 32.7 1.1 1.2e-07 31.8 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) ICMT PF04140.14 KOO25919.1 - 0.0002 21.7 2.0 0.00031 21.1 0.0 2.3 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.16 KOO25919.1 - 0.052 13.5 0.0 0.14 12.1 0.0 1.7 2 0 0 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase 2-Hacid_dh_C PF02826.19 KOO25920.1 - 1.5e-33 115.6 0.0 7.6e-24 84.0 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain EF-hand_1 PF00036.32 KOO25921.1 - 2.3e-26 89.3 1.7 1.4e-05 24.3 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO25921.1 - 5.4e-23 78.9 0.9 0.00015 21.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO25921.1 - 5e-22 76.4 3.9 0.00032 20.1 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO25921.1 - 1.4e-17 63.9 0.5 9.2e-07 29.2 0.0 3.2 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO25921.1 - 1.8e-14 53.3 4.7 0.00059 19.6 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain pair Epimerase PF01370.21 KOO25921.1 - 0.00021 20.8 0.0 0.00032 20.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO25921.1 - 0.013 14.9 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase SPARC_Ca_bdg PF10591.9 KOO25921.1 - 0.016 15.5 0.2 17 5.8 0.1 3.6 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.12 KOO25921.1 - 0.028 14.6 0.0 0.47 10.6 0.0 2.1 1 1 0 2 2 2 0 p25-alpha Polysacc_deac_1 PF01522.21 KOO25922.1 - 9.7e-09 35.2 0.0 2.8e-08 33.7 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase EF-hand_7 PF13499.6 KOO25923.1 - 3.5e-10 40.2 0.1 6.8e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO25923.1 - 2.1e-09 36.6 0.1 3.5e-07 29.6 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO25923.1 - 4e-08 32.2 0.0 1.6e-06 27.2 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO25923.1 - 7.6e-06 25.2 0.0 1.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO25923.1 - 0.017 15.0 0.0 0.065 13.1 0.0 1.8 1 1 1 2 2 2 0 EF-hand domain pair GreA_GreB_N PF03449.15 KOO25923.1 - 0.018 15.2 0.5 0.04 14.1 0.5 1.5 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal SPARC_Ca_bdg PF10591.9 KOO25923.1 - 0.24 11.7 0.0 0.44 10.9 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region His_Phos_1 PF00300.22 KOO25924.1 - 1.9e-34 119.1 1.5 3.8e-24 85.5 0.2 2.7 2 1 1 3 3 3 2 Histidine phosphatase superfamily (branch 1) TPR_12 PF13424.6 KOO25925.1 - 2.7e-51 171.7 26.2 1.1e-18 67.2 3.9 4.8 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO25925.1 - 2.3e-43 144.9 12.3 2.1e-13 49.7 0.2 5.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO25925.1 - 1.9e-14 52.5 12.6 0.00031 20.5 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25925.1 - 5.5e-14 51.3 3.4 0.0014 18.4 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25925.1 - 2.3e-13 49.2 7.5 0.0004 20.4 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO25925.1 - 1.5e-08 34.1 16.8 0.0091 16.0 0.1 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25925.1 - 2.8e-05 24.2 0.5 2.1 8.9 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25925.1 - 0.02 15.6 1.8 0.02 15.6 1.8 7.0 6 1 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO25925.1 - 0.063 13.0 0.6 10 5.9 0.1 3.5 3 0 0 3 3 3 0 TPR repeat TPR_14 PF13428.6 KOO25925.1 - 0.2 12.6 0.1 0.2 12.6 0.1 6.7 8 1 0 8 8 5 0 Tetratricopeptide repeat ZapB PF06005.12 KOO25925.1 - 0.25 11.8 0.1 0.25 11.8 0.1 6.8 7 0 0 7 7 7 0 Cell division protein ZapB DUF1687 PF07955.11 KOO25925.1 - 0.26 11.8 2.0 0.49 10.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1687) UDPGP PF01704.18 KOO25926.1 - 4.2e-11 42.1 0.0 7.4e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase SBBP PF06739.11 KOO25929.1 - 1.4e-12 47.3 52.0 0.0017 18.3 0.4 9.3 9 0 0 9 9 9 7 Beta-propeller repeat DUF1398 PF07166.11 KOO25929.1 - 0.27 11.3 4.4 25 5.0 0.0 4.9 6 0 0 6 6 6 0 Protein of unknown function (DUF1398) MMR_HSR1 PF01926.23 KOO25930.1 - 5.3e-07 29.7 0.1 4.8e-06 26.6 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOO25930.1 - 0.00025 21.1 0.0 0.025 14.6 0.0 2.5 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 KOO25930.1 - 0.00083 19.3 0.0 0.0034 17.3 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 KOO25930.1 - 0.0018 17.6 0.2 0.012 15.0 0.2 2.1 1 1 0 1 1 1 1 AIG1 family AAA_16 PF13191.6 KOO25930.1 - 0.002 18.5 0.0 0.0053 17.2 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 KOO25930.1 - 0.0023 18.5 0.0 0.0046 17.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 KOO25930.1 - 0.011 16.0 0.0 0.038 14.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 KOO25930.1 - 0.03 13.9 0.0 0.15 11.6 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain T2SSE PF00437.20 KOO25930.1 - 0.031 13.3 0.0 0.053 12.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 KOO25930.1 - 0.065 13.5 0.0 0.21 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOO25930.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Vps5 PF09325.10 KOO25931.1 - 7.3e-26 91.2 1.3 1.3e-25 90.4 1.3 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 KOO25931.1 - 3.2e-24 85.1 0.3 5e-24 84.5 0.3 1.3 1 0 0 1 1 1 1 PX domain BAR PF03114.18 KOO25931.1 - 7.6e-06 25.7 0.9 7.6e-06 25.7 0.9 2.1 2 0 0 2 2 2 1 BAR domain BAR_3_WASP_bdg PF10456.9 KOO25931.1 - 0.00074 19.1 1.6 0.015 14.8 1.6 2.2 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein FAM92 PF06730.11 KOO25931.1 - 0.003 17.0 2.5 0.0096 15.4 2.5 1.7 1 1 0 1 1 1 1 FAM92 protein EF-hand_7 PF13499.6 KOO25932.1 - 4.7e-12 46.2 2.9 2.3e-08 34.3 0.7 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO25932.1 - 1.3e-11 43.1 3.3 0.00085 18.7 0.4 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO25932.1 - 1.8e-10 39.8 6.3 0.011 15.6 0.1 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KOO25932.1 - 2.4e-09 36.3 6.9 0.003 17.0 0.8 3.9 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO25932.1 - 1.4e-07 31.3 1.7 9.3e-07 28.6 0.4 2.6 2 1 0 2 2 2 1 EF-hand domain pair Col_cuticle_N PF01484.17 KOO25933.1 - 0.078 13.1 0.2 2.3 8.4 0.2 2.5 1 1 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Glyco_hydro_3_C PF01915.22 KOO25934.1 - 1.7e-44 152.2 0.0 3.8e-44 151.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOO25934.1 - 5.3e-29 101.6 0.0 1.2e-28 100.5 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOO25934.1 - 4.9e-14 52.2 0.1 9.9e-14 51.2 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PAN_1 PF00024.26 KOO25934.1 - 7.1e-07 29.1 5.0 1.3e-06 28.2 5.0 1.5 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 KOO25934.1 - 0.087 12.7 3.5 0.18 11.7 3.5 1.5 1 0 0 1 1 1 0 PAN domain PRIMA1 PF16101.5 KOO25934.1 - 3.2 7.8 6.0 3.3 7.7 0.1 2.6 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 EF-hand_5 PF13202.6 KOO25935.1 - 0.0005 19.4 0.2 0.0021 17.4 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO25935.1 - 0.00095 19.6 0.1 0.0021 18.5 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO25935.1 - 0.0013 18.1 0.1 0.014 14.9 0.0 2.5 2 1 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO25935.1 - 0.0019 17.9 0.1 0.014 15.3 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain Peptidase_S10 PF00450.22 KOO25936.1 - 4.3e-87 293.2 0.0 6e-87 292.8 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase DUF2920 PF11144.8 KOO25936.1 - 0.041 13.0 0.0 0.058 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) TPR_14 PF13428.6 KOO25937.1 - 1.3e-37 125.3 83.5 0.0003 21.4 1.7 17.8 3 2 15 18 18 18 13 Tetratricopeptide repeat TPR_2 PF07719.17 KOO25937.1 - 1.1e-36 121.9 50.7 0.039 14.1 0.0 18.0 17 2 2 19 19 19 11 Tetratricopeptide repeat TPR_19 PF14559.6 KOO25937.1 - 1.5e-32 111.9 42.5 0.0007 20.1 0.4 10.3 6 3 5 12 12 12 10 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25937.1 - 3.8e-26 91.4 84.0 0.00029 21.4 0.4 10.5 6 3 2 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25937.1 - 2.3e-23 80.8 12.8 0.046 14.1 0.2 12.8 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25937.1 - 9.2e-21 73.9 53.6 0.00023 21.4 0.0 12.5 5 4 8 13 13 13 7 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25937.1 - 2.3e-20 71.5 2.1 0.031 14.1 0.0 12.2 14 0 0 14 14 13 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25937.1 - 2.3e-20 71.0 0.1 0.39 11.0 0.1 13.9 16 0 0 16 16 15 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO25937.1 - 3.1e-13 49.6 26.9 0.017 14.4 8.4 7.0 2 2 3 6 6 6 4 Tetratricopeptide repeat TPR_9 PF13371.6 KOO25937.1 - 1.2e-11 44.5 65.0 0.00055 20.0 0.6 10.8 4 3 7 11 11 11 5 Tetratricopeptide repeat Suf PF05843.14 KOO25937.1 - 4.5e-11 43.3 0.0 0.027 14.4 0.0 5.2 3 2 2 5 5 5 3 Suppressor of forked protein (Suf) TPR_6 PF13174.6 KOO25937.1 - 7.3e-10 38.8 38.3 1.2 9.9 0.0 14.4 16 1 1 17 17 15 2 Tetratricopeptide repeat Coatomer_E PF04733.14 KOO25937.1 - 1.8e-08 34.2 0.0 0.05 13.0 0.0 4.5 4 2 1 5 5 5 2 Coatomer epsilon subunit TPR_11 PF13414.6 KOO25937.1 - 2e-07 30.5 8.1 18 5.1 0.0 10.0 10 1 1 11 11 11 0 TPR repeat NARP1 PF12569.8 KOO25937.1 - 0.00014 21.0 0.5 1.2 7.9 0.0 4.7 4 1 1 5 5 5 1 NMDA receptor-regulated protein 1 DUF3808 PF10300.9 KOO25937.1 - 0.021 13.6 1.5 2.5 6.7 0.0 3.8 5 0 0 5 5 5 0 Protein of unknown function (DUF3808) ANAPC3 PF12895.7 KOO25937.1 - 0.052 13.8 7.8 1.5 9.1 0.1 4.6 5 1 2 7 7 6 0 Anaphase-promoting complex, cyclosome, subunit 3 FAT PF02259.23 KOO25937.1 - 0.25 10.5 3.9 2.1 7.5 0.0 3.8 4 1 1 5 5 5 0 FAT domain DUF2379 PF09543.10 KOO25937.1 - 0.36 11.0 0.0 0.36 11.0 0.0 3.8 4 1 2 6 6 6 0 Protein of unknown function (DUF2379) Mad3_BUB1_I PF08311.12 KOO25937.1 - 0.46 10.5 6.9 28 4.7 0.0 6.1 8 1 1 9 9 9 0 Mad3/BUB1 homology region 1 TPR_7 PF13176.6 KOO25937.1 - 1.2 9.4 19.7 46 4.4 0.0 9.0 12 0 0 12 12 11 0 Tetratricopeptide repeat DUF3450 PF11932.8 KOO25938.1 - 0.023 14.0 2.6 0.032 13.5 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) HrpA_pilin PF09589.10 KOO25938.1 - 0.052 14.2 1.8 0.091 13.5 1.8 1.4 1 0 0 1 1 1 0 HrpA pilus formation protein Methyltransf_21 PF05050.12 KOO25939.1 - 1.5e-13 51.2 0.0 1.8e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain Phage_integrase PF00589.22 KOO25940.1 - 0.0052 16.6 0.0 0.007 16.2 0.0 1.2 1 0 0 1 1 1 1 Phage integrase family Sugar_tr PF00083.24 KOO25941.1 - 6e-07 28.7 3.3 6.9e-07 28.5 3.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO25941.1 - 3.3e-06 26.3 3.4 4.1e-06 26.0 3.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily EF-hand_5 PF13202.6 KOO25941.1 - 1.1e-05 24.7 6.7 0.4 10.3 0.1 4.5 3 1 1 4 4 4 3 EF hand EF-hand_1 PF00036.32 KOO25941.1 - 0.0055 16.2 7.6 1.6 8.5 0.1 4.9 3 2 2 5 5 5 2 EF hand Dockerin_1 PF00404.18 KOO25941.1 - 0.0059 16.8 2.9 2.1 8.6 0.1 2.9 1 1 1 2 2 2 2 Dockerin type I domain EF-hand_6 PF13405.6 KOO25941.1 - 0.22 11.5 6.8 12 6.2 0.2 4.7 3 2 2 5 5 5 0 EF-hand domain EF-hand_7 PF13499.6 KOO25941.1 - 2.4 8.7 6.0 2.1 8.8 0.8 3.1 1 1 2 3 3 3 0 EF-hand domain pair PAE PF03283.13 KOO25942.1 - 2.3e-15 56.6 0.0 3.4e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Pectinacetylesterase Caps_assemb_Wzi PF14052.6 KOO25942.1 - 0.14 11.2 0.0 0.19 10.7 0.0 1.1 1 0 0 1 1 1 0 Capsule assembly protein Wzi Sugar_tr PF00083.24 KOO25943.1 - 7e-09 35.0 28.3 2.2e-05 23.5 4.8 2.8 2 2 0 2 2 2 2 Sugar (and other) transporter TcpQ PF10671.9 KOO25943.1 - 0.15 12.2 0.0 13 6.0 0.0 2.5 2 0 0 2 2 2 0 Toxin co-regulated pilus biosynthesis protein Q PAP_fibrillin PF04755.12 KOO25944.1 - 1e-14 55.0 0.0 1.9e-09 37.7 0.0 2.2 2 0 0 2 2 2 2 PAP_fibrillin DAO PF01266.24 KOO25945.1 - 2.5e-24 86.5 0.5 3.4e-24 86.1 0.5 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOO25945.1 - 0.00031 20.9 0.2 0.0013 19.0 0.3 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 KOO25945.1 - 0.00045 19.4 2.6 0.14 11.2 2.2 2.4 2 1 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 KOO25945.1 - 0.0016 17.8 1.8 0.076 12.2 0.4 2.6 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOO25945.1 - 0.022 14.8 2.0 1.9 8.5 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 KOO25945.1 - 0.024 13.9 1.5 0.12 11.6 0.7 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOO25945.1 - 0.041 13.1 0.4 0.081 12.1 0.4 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.19 KOO25945.1 - 0.052 12.8 0.5 0.079 12.2 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 KOO25945.1 - 0.058 13.5 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 KOO25945.1 - 0.091 12.1 0.3 0.15 11.4 0.3 1.3 1 0 0 1 1 1 0 ThiF family FAD_binding_2 PF00890.24 KOO25945.1 - 0.14 11.2 2.8 0.09 11.8 0.8 1.6 2 0 0 2 2 2 0 FAD binding domain Sugar_tr PF00083.24 KOO25946.1 - 4.3e-35 121.4 11.6 2.1e-18 66.4 4.0 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOO25946.1 - 1.2e-24 86.9 41.0 1.7e-21 76.5 26.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily YtxH PF12732.7 KOO25946.1 - 0.025 15.1 0.2 0.081 13.5 0.2 1.9 1 0 0 1 1 1 0 YtxH-like protein SLATT_6 PF18169.1 KOO25946.1 - 0.21 11.1 0.1 0.51 9.9 0.1 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 MWFE PF15879.5 KOO25946.1 - 0.59 10.3 3.1 55 4.0 0.0 3.6 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase MWFE subunit MerC PF03203.14 KOO25946.1 - 3.9 8.0 8.9 0.72 10.3 1.8 3.1 2 2 1 3 3 3 0 MerC mercury resistance protein ADH_N PF08240.12 KOO25947.1 - 1.1e-09 38.1 0.2 2.4e-09 37.0 0.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Filamin PF00630.19 KOO25948.1 - 1.3e-13 51.6 0.0 5.4e-12 46.4 0.0 2.6 2 0 0 2 2 2 1 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO25948.1 - 0.0072 16.6 1.3 0.036 14.4 0.0 2.8 2 0 0 2 2 2 1 Invasin, domain 3 Neurexophilin PF06312.12 KOO25948.1 - 0.029 13.9 0.0 0.063 12.7 0.0 1.5 1 0 0 1 1 1 0 Neurexophilin FidL_like PF15941.5 KOO25948.1 - 0.076 13.5 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 FidL-like putative membrane protein MMR_HSR1 PF01926.23 KOO25949.1 - 1.3e-48 163.8 0.4 1e-25 90.0 0.1 2.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 KOO25949.1 - 6.4e-28 96.9 0.0 1.7e-27 95.5 0.0 1.8 2 0 0 2 2 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 KOO25949.1 - 1.8e-23 82.8 0.0 2.5e-13 49.9 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 KOO25949.1 - 7.9e-17 61.4 0.9 7.4e-08 32.2 0.1 5.1 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KOO25949.1 - 8e-12 44.9 0.1 5.4e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 AIG1 family RsgA_GTPase PF03193.16 KOO25949.1 - 7.5e-09 35.7 0.0 0.075 12.9 0.0 3.9 4 0 0 4 4 4 2 RsgA GTPase Dynamin_N PF00350.23 KOO25949.1 - 9.4e-09 35.5 0.0 0.041 14.0 0.1 3.5 3 1 1 4 4 3 3 Dynamin family Roc PF08477.13 KOO25949.1 - 2.1e-07 31.2 0.3 0.01 16.1 0.1 3.5 3 1 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 KOO25949.1 - 9.9e-06 26.1 0.1 0.016 15.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain Ras PF00071.22 KOO25949.1 - 1.1e-05 25.1 0.5 0.0073 15.9 0.1 3.1 3 1 0 3 3 3 1 Ras family AAA_22 PF13401.6 KOO25949.1 - 2.1e-05 24.8 0.7 0.019 15.2 0.0 3.5 3 1 0 3 3 3 1 AAA domain SRPRB PF09439.10 KOO25949.1 - 2.5e-05 23.8 0.1 0.1 12.0 0.0 3.9 3 1 0 3 3 3 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KOO25949.1 - 2.7e-05 24.6 0.2 0.56 10.6 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain cobW PF02492.19 KOO25949.1 - 4e-05 23.3 1.0 0.00084 19.0 0.0 3.0 2 2 1 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 KOO25949.1 - 6.6e-05 22.7 0.1 0.37 10.5 0.0 2.5 3 0 0 3 3 2 2 AAA domain PduV-EutP PF10662.9 KOO25949.1 - 8.7e-05 22.3 0.0 0.069 12.9 0.0 3.6 4 0 0 4 4 4 1 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 KOO25949.1 - 0.00012 22.3 0.3 0.62 10.3 0.0 3.3 3 0 0 3 3 3 2 AAA domain ABC_tran PF00005.27 KOO25949.1 - 0.00014 22.4 0.0 0.54 10.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter Arf PF00025.21 KOO25949.1 - 0.00019 20.9 0.1 0.19 11.2 0.1 3.0 2 1 0 2 2 2 1 ADP-ribosylation factor family SRP54 PF00448.22 KOO25949.1 - 0.00043 20.0 0.8 1.2 8.7 0.0 2.9 3 0 0 3 3 3 2 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 KOO25949.1 - 0.00082 19.7 0.0 0.44 11.0 0.0 2.7 3 0 0 3 3 2 1 RNA helicase Ploopntkinase3 PF18751.1 KOO25949.1 - 0.0011 18.9 0.0 0.38 10.6 0.0 2.5 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 MeaB PF03308.16 KOO25949.1 - 0.0016 17.5 0.1 0.31 10.0 0.0 2.8 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB TniB PF05621.11 KOO25949.1 - 0.0019 17.6 0.0 0.9 8.9 0.0 3.1 3 0 0 3 3 3 1 Bacterial TniB protein KTI12 PF08433.10 KOO25949.1 - 0.0026 17.3 0.1 0.054 12.9 0.0 2.7 3 0 0 3 3 3 1 Chromatin associated protein KTI12 G-alpha PF00503.20 KOO25949.1 - 0.0055 15.9 0.0 1.9 7.6 0.0 2.4 2 0 0 2 2 2 1 G-protein alpha subunit 6PF2K PF01591.18 KOO25949.1 - 0.0084 15.4 0.2 0.089 12.1 0.0 2.5 2 1 1 3 3 3 1 6-phosphofructo-2-kinase AAA_25 PF13481.6 KOO25949.1 - 0.025 14.1 0.0 1.9 8.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 KOO25949.1 - 0.032 13.4 0.0 0.56 9.3 0.0 2.4 3 0 0 3 3 3 0 NB-ARC domain NTPase_1 PF03266.15 KOO25949.1 - 0.034 14.1 1.3 1.9 8.4 0.0 3.0 3 1 0 3 3 3 0 NTPase MCM PF00493.23 KOO25949.1 - 0.041 13.0 0.1 7.9 5.5 0.0 3.1 4 0 0 4 4 4 0 MCM P-loop domain AAA PF00004.29 KOO25949.1 - 0.047 14.1 0.4 18 5.8 0.0 3.1 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 KOO25949.1 - 0.11 11.8 0.0 0.43 9.8 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin MobB PF03205.14 KOO25949.1 - 0.14 12.1 0.1 11 5.9 0.0 3.0 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Parvo_NS1 PF01057.17 KOO25949.1 - 0.15 11.1 0.0 0.34 9.9 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Pkinase PF00069.25 KOO25950.1 - 3.5e-10 39.7 0.0 3.7e-10 39.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain CHASE PF03924.13 KOO25950.1 - 0.017 15.0 0.0 0.019 14.9 0.0 1.0 1 0 0 1 1 1 0 CHASE domain Pkinase_Tyr PF07714.17 KOO25950.1 - 0.018 14.3 0.0 0.021 14.1 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase Helicase_C PF00271.31 KOO25951.1 - 6.2e-13 49.1 0.0 1e-12 48.4 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 KOO25951.1 - 9.1e-13 48.4 0.2 9.1e-11 42.0 0.0 2.8 2 0 0 2 2 2 1 Helicase associated domain (HA2) Acyl_transf_3 PF01757.22 KOO25952.1 - 2.3e-19 69.7 11.0 2.3e-19 69.7 11.0 3.1 3 0 0 3 3 3 2 Acyltransferase family Metallophos PF00149.28 KOO25953.1 - 1.6e-06 28.8 0.0 2.5e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GTP_cyclohydro2 PF00925.20 KOO25955.1 - 3.1e-40 137.4 0.0 4e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II Cyclin_N PF00134.23 KOO25956.1 - 5.9e-22 77.8 0.0 9.5e-22 77.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOO25956.1 - 0.014 15.5 0.4 0.063 13.4 0.1 2.0 2 0 0 2 2 2 0 Cyclin, C-terminal domain DUF3606 PF12244.8 KOO25956.1 - 0.13 12.2 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) DEAD PF00270.29 KOO25957.1 - 0.0099 15.7 0.1 0.013 15.3 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase FtsJ PF01728.19 KOO25959.1 - 4.7e-21 75.7 0.0 7.3e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase WW PF00397.26 KOO25959.1 - 0.0005 20.1 0.4 0.0011 19.1 0.4 1.5 1 0 0 1 1 1 1 WW domain Nucleotid_trans PF03407.16 KOO25960.1 - 1.9e-09 37.8 0.0 2.7e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Ferrochelatase PF00762.19 KOO25964.1 - 3.5e-108 361.5 0.0 4.1e-108 361.2 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 KOO25964.1 - 0.0017 18.6 0.0 1.6 9.1 0.0 2.9 3 0 0 3 3 3 2 CbiX GST_N_3 PF13417.6 KOO25966.1 - 1.4e-10 41.4 0.0 9.9e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO25966.1 - 4.1e-10 39.8 0.0 9.4e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO25966.1 - 1.2e-09 38.1 0.9 4e-09 36.4 0.9 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 KOO25966.1 - 0.0011 19.5 0.0 0.0046 17.5 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOO25966.1 - 0.0076 16.6 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOO25966.1 - 0.077 13.2 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1917 PF08939.10 KOO25967.1 - 1.4e-19 71.1 0.2 1.4e-19 71.1 0.2 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF1917) SNF2_N PF00176.23 KOO25968.1 - 3.9e-17 62.0 0.0 7.4e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 KOO25968.1 - 0.00051 19.9 0.0 0.015 15.1 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO25968.1 - 0.0022 18.0 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOO25968.1 - 0.0058 16.9 0.0 0.044 14.1 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_34 PF13872.6 KOO25968.1 - 0.12 11.2 0.0 0.25 10.2 0.0 1.5 1 1 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 CRAL_TRIO_2 PF13716.6 KOO25969.1 - 1e-24 87.3 0.0 1.8e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Macro PF01661.21 KOO25969.1 - 4.7e-22 78.2 0.1 1.1e-21 77.0 0.1 1.7 1 0 0 1 1 1 1 Macro domain CRAL_TRIO PF00650.20 KOO25969.1 - 0.00011 21.9 0.0 0.00025 20.8 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO domain MOFRL PF05161.13 KOO25969.1 - 0.082 13.1 0.5 0.38 11.0 0.5 2.2 1 0 0 1 1 1 0 MOFRL family Baculo_PEP_C PF04513.12 KOO25969.1 - 3.7 7.6 19.8 2.7 8.0 0.5 4.2 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Yuri_gagarin PF15934.5 KOO25969.1 - 9.7 6.0 13.5 1 9.2 7.0 2.3 2 0 0 2 2 2 0 Yuri gagarin TPR_1 PF00515.28 KOO25970.1 - 9.4e-27 91.7 31.5 2e-06 27.4 0.1 10.9 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25970.1 - 1.6e-26 92.4 22.7 7e-08 32.7 0.0 9.2 6 3 2 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOO25970.1 - 3.7e-26 89.1 32.2 0.0022 18.0 0.0 12.3 14 0 0 14 14 13 6 Tetratricopeptide repeat TPR_19 PF14559.6 KOO25970.1 - 8.2e-21 74.3 12.6 0.0073 16.8 0.1 8.3 7 2 1 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25970.1 - 3.2e-20 70.6 22.9 0.053 13.8 0.1 12.0 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO25970.1 - 9.9e-20 70.9 13.0 0.00015 22.3 0.2 6.5 6 2 0 7 7 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOO25970.1 - 3.1e-18 64.9 10.4 0.013 16.2 0.0 10.0 5 3 6 11 11 10 3 Tetratricopeptide repeat TPR_6 PF13174.6 KOO25970.1 - 7.2e-18 64.0 17.0 0.3 11.8 0.0 11.1 13 0 0 13 13 11 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO25970.1 - 1.4e-16 59.2 17.3 0.003 17.5 0.0 10.6 12 0 0 12 12 11 4 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO25970.1 - 1.4e-13 50.9 19.0 0.00029 21.0 0.3 6.7 6 1 1 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 KOO25970.1 - 1.7e-11 43.6 15.5 0.0015 18.2 0.1 7.8 7 1 2 9 9 9 3 TPR repeat TPR_10 PF13374.6 KOO25970.1 - 2.7e-08 33.4 18.4 0.085 12.8 0.1 8.1 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_21 PF09976.9 KOO25970.1 - 6.7e-08 32.5 11.8 9.3e-06 25.5 3.0 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat-like domain TPR_9 PF13371.6 KOO25970.1 - 2e-06 27.9 1.9 3 8.0 0.0 5.3 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 KOO25970.1 - 8.4e-05 21.9 4.3 0.0032 16.7 0.1 4.3 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO25970.1 - 0.00031 20.2 3.3 0.54 9.6 0.0 3.9 2 2 3 5 5 5 3 MalT-like TPR region TPR_17 PF13431.6 KOO25970.1 - 0.00057 20.1 11.8 7.3 7.2 0.1 9.2 10 0 0 10 10 10 0 Tetratricopeptide repeat Rapsyn_N PF10579.9 KOO25970.1 - 0.0052 16.9 0.6 0.15 12.2 0.1 3.5 4 0 0 4 4 3 1 Rapsyn N-terminal myristoylation and linker region NARP1 PF12569.8 KOO25970.1 - 0.0081 15.1 18.2 0.045 12.7 6.3 3.7 2 2 1 4 4 4 2 NMDA receptor-regulated protein 1 ChAPs PF09295.10 KOO25970.1 - 0.021 13.9 0.1 0.072 12.1 0.0 1.7 1 1 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_4 PF07721.14 KOO25970.1 - 0.024 15.2 0.0 12 6.9 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat RPN7 PF10602.9 KOO25970.1 - 0.035 13.8 0.2 0.035 13.8 0.2 5.9 3 1 4 7 7 7 0 26S proteasome subunit RPN7 DUF4810 PF16068.5 KOO25970.1 - 0.046 14.3 1.3 1.2 9.7 0.0 3.9 4 1 0 4 4 3 0 Domain of unknown function (DUF4810) TPR_20 PF14561.6 KOO25970.1 - 0.053 13.9 8.9 1.3 9.4 0.0 5.7 6 1 0 6 6 6 0 Tetratricopeptide repeat HHH_8 PF14716.6 KOO25970.1 - 0.079 13.3 0.6 1.6 9.1 0.1 2.8 2 0 0 2 2 2 0 Helix-hairpin-helix domain SHMT PF00464.19 KOO25971.1 - 8.2e-176 584.4 0.0 1e-175 584.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase 2-Hacid_dh_C PF02826.19 KOO25972.1 - 9.6e-41 139.1 0.0 1.4e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 KOO25972.1 - 9.6e-05 22.6 0.1 0.00034 20.8 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 KOO25972.1 - 0.0026 17.8 0.0 0.0046 17.0 0.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 KOO25972.1 - 0.0062 16.1 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 KOO25972.1 - 0.0079 16.3 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ABC_tran PF00005.27 KOO25973.1 - 1.6e-41 142.0 0.7 2.8e-19 70.0 0.1 4.4 2 2 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOO25973.1 - 9.9e-13 48.0 0.2 2.1e-05 24.1 0.1 4.0 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOO25973.1 - 3.5e-11 43.5 0.3 0.026 14.3 0.0 4.2 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOO25973.1 - 9.4e-07 28.5 2.5 0.0073 16.0 0.0 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO25973.1 - 8.4e-06 26.1 0.0 0.0075 16.5 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 KOO25973.1 - 9.5e-06 26.3 0.9 0.043 14.3 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KOO25973.1 - 1.5e-05 25.4 0.1 0.17 12.3 0.0 3.6 4 0 0 4 4 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 KOO25973.1 - 6.9e-05 22.8 0.1 0.48 10.3 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase MeaB PF03308.16 KOO25973.1 - 0.00014 21.0 0.9 0.2 10.6 0.1 3.1 2 1 1 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 KOO25973.1 - 0.00014 22.2 0.0 0.24 11.8 0.0 3.1 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 KOO25973.1 - 0.00019 22.0 0.1 0.16 12.5 0.0 3.1 3 0 0 3 3 2 1 AAA domain MMR_HSR1 PF01926.23 KOO25973.1 - 0.00025 21.1 0.2 0.31 11.1 0.1 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Chromo PF00385.24 KOO25973.1 - 0.00068 19.5 0.4 0.0019 18.1 0.4 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_33 PF13671.6 KOO25973.1 - 0.00074 19.7 0.0 1.1 9.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KOO25973.1 - 0.0008 19.8 0.0 0.29 11.5 0.0 3.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOO25973.1 - 0.0016 18.2 0.5 1.9 8.2 0.0 3.3 3 0 0 3 3 3 1 AAA domain DUF87 PF01935.17 KOO25973.1 - 0.0018 18.4 0.1 0.15 12.2 0.0 2.8 2 0 0 2 2 2 1 Helicase HerA, central domain NACHT PF05729.12 KOO25973.1 - 0.0024 17.8 0.1 0.39 10.6 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_27 PF13514.6 KOO25973.1 - 0.0025 17.4 0.0 0.16 11.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 KOO25973.1 - 0.0026 17.5 0.1 3.9 7.2 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_7 PF12775.7 KOO25973.1 - 0.0043 16.6 0.2 6.6 6.2 0.0 3.2 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_14 PF13173.6 KOO25973.1 - 0.0046 17.0 0.0 0.93 9.5 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 KOO25973.1 - 0.0084 16.4 0.0 1.7 8.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 KOO25973.1 - 0.018 14.7 0.3 0.51 9.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 KOO25973.1 - 0.029 13.5 0.0 2.6 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Tti2 PF10521.9 KOO25973.1 - 0.031 13.8 0.5 0.28 10.7 0.1 2.4 2 1 0 2 2 1 0 Tti2 family HEAT PF02985.22 KOO25973.1 - 0.032 14.5 1.5 3.5 8.1 0.0 4.2 5 0 0 5 5 3 0 HEAT repeat HEAT_EZ PF13513.6 KOO25973.1 - 0.043 14.3 0.4 0.45 11.1 0.1 2.9 3 0 0 3 3 2 0 HEAT-like repeat TsaE PF02367.17 KOO25973.1 - 0.053 13.5 0.0 3.1 7.8 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 KOO25973.1 - 0.054 12.7 0.1 0.65 9.1 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain ATP_bind_1 PF03029.17 KOO25973.1 - 0.055 13.2 0.1 12 5.5 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_15 PF13175.6 KOO25973.1 - 0.063 13.0 3.3 7.5 6.1 0.0 3.3 3 0 0 3 3 3 0 AAA ATPase domain NTPase_1 PF03266.15 KOO25973.1 - 0.077 12.9 0.1 16 5.4 0.0 2.7 2 0 0 2 2 2 0 NTPase CLP1_P PF16575.5 KOO25973.1 - 0.12 12.1 0.0 0.75 9.6 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Dynamin_N PF00350.23 KOO25973.1 - 0.14 12.2 1.6 1.5 8.9 0.0 3.4 4 0 0 4 4 4 0 Dynamin family AAA_5 PF07728.14 KOO25973.1 - 0.16 12.0 0.1 3.6 7.6 0.0 3.1 4 0 0 4 4 2 0 AAA domain (dynein-related subfamily) AAA_13 PF13166.6 KOO25973.1 - 0.64 8.6 6.6 58 2.1 5.2 3.2 3 0 0 3 3 3 0 AAA domain Got1 PF04178.12 KOO25974.1 - 1.7e-29 102.5 9.5 2.7e-29 101.9 9.5 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family Tmemb_cc2 PF10267.9 KOO25976.1 - 0.00088 18.5 1.1 0.001 18.3 1.1 1.2 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein COX16 PF14138.6 KOO25976.1 - 0.069 13.7 0.1 0.38 11.3 0.0 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein COX16 CENP-H PF05837.12 KOO25976.1 - 0.12 12.8 3.9 0.22 11.9 3.9 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Rx_N PF18052.1 KOO25976.1 - 0.15 12.4 5.5 1.9 8.8 0.2 2.6 1 1 1 2 2 2 0 Rx N-terminal domain DUF745 PF05335.13 KOO25976.1 - 0.18 11.5 8.6 0.79 9.4 8.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Exonuc_VII_L PF02601.15 KOO25976.1 - 0.25 10.9 4.8 0.34 10.4 4.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sec2p PF06428.11 KOO25976.1 - 0.35 10.9 4.2 0.44 10.6 2.3 2.0 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Atg14 PF10186.9 KOO25976.1 - 0.4 9.7 7.1 0.54 9.3 7.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 KOO25976.1 - 0.42 9.5 6.7 0.66 8.8 6.6 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Peptidase_S8 PF00082.22 KOO25977.1 - 1.5e-23 83.5 0.0 2.3e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Subtilase family DNA_ligase_A_M PF01068.21 KOO25978.1 - 1.1e-07 31.7 0.0 2.1e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 KOO25978.1 - 0.00015 22.1 0.0 0.00027 21.3 0.0 1.4 1 0 0 1 1 1 1 RNA ligase DNA_ligase_OB_2 PF14743.6 KOO25978.1 - 0.00044 20.2 0.0 0.00097 19.1 0.0 1.7 1 0 0 1 1 1 1 DNA ligase OB-like domain ADH_zinc_N_2 PF13602.6 KOO25979.1 - 1.4e-16 61.7 0.1 2.7e-16 60.8 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOO25979.1 - 1.2e-14 54.4 0.4 3.3e-14 53.0 0.3 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOO25979.1 - 2.5e-09 37.0 0.1 5.1e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Semialdhyde_dh PF01118.24 KOO25979.1 - 0.039 14.4 0.1 0.064 13.7 0.1 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain COX15-CtaA PF02628.15 KOO25980.1 - 3.6e-94 315.5 12.6 5e-94 315.0 12.6 1.2 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein WD40 PF00400.32 KOO25980.1 - 6.3e-51 169.3 12.9 1.7e-08 35.0 0.2 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO25980.1 - 4.1e-17 62.1 3.0 0.013 14.5 0.0 6.1 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO25980.1 - 1.2e-13 51.1 2.5 0.26 11.6 0.0 6.0 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO25980.1 - 2.3e-10 40.1 0.1 4.8 7.2 0.0 5.6 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat eIF2A PF08662.11 KOO25980.1 - 1.3e-08 35.0 0.1 0.0056 16.6 0.0 3.6 1 1 2 4 4 4 4 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 KOO25980.1 - 1.3e-05 23.8 0.0 0.063 11.6 0.0 4.0 1 1 2 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO25980.1 - 3.9e-05 23.1 4.1 7.5 5.8 0.1 5.3 1 1 5 6 6 6 2 Neuroblastoma-amplified sequence, N terminal LigD_N PF13298.6 KOO25980.1 - 0.00057 20.1 0.5 15 5.9 0.0 4.4 1 1 2 4 4 4 0 DNA polymerase Ligase (LigD) rOmpB PF12334.8 KOO25980.1 - 0.031 13.8 6.0 22 4.4 0.0 5.8 3 1 4 7 7 7 0 Rickettsia outer membrane protein B Cyt_c_ox_IV PF12270.8 KOO25980.1 - 0.075 13.2 0.5 0.26 11.5 0.5 1.9 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV DUF1269 PF06897.12 KOO25980.1 - 2.3 8.5 4.8 7.5 6.9 0.9 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) zf-C3HC4_3 PF13920.6 KOO25982.1 - 4.4e-16 58.5 12.7 6.9e-16 57.9 12.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) NHL PF01436.21 KOO25982.1 - 7.2e-11 41.5 0.0 0.0068 16.4 0.0 4.4 4 0 0 4 4 4 3 NHL repeat Prok-RING_4 PF14447.6 KOO25982.1 - 2.8e-07 30.3 11.4 4.9e-07 29.5 11.4 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOO25982.1 - 8.6e-05 22.8 13.4 0.00015 22.0 13.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-P11 PF03854.14 KOO25982.1 - 0.0021 17.7 6.8 0.0041 16.7 6.8 1.5 1 0 0 1 1 1 1 P-11 zinc finger zf-RING_5 PF14634.6 KOO25982.1 - 0.0042 17.0 11.8 0.0073 16.2 11.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-ribbon_3 PF13248.6 KOO25982.1 - 0.05 13.0 0.5 0.11 11.9 0.5 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zf-C3HC4_2 PF13923.6 KOO25982.1 - 0.087 12.7 14.3 0.16 11.9 14.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Urocanase_C PF17392.2 KOO25982.1 - 0.13 11.7 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Urocanase C-terminal domain zf-RING_4 PF14570.6 KOO25982.1 - 8.1 6.3 10.5 14 5.6 10.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain CPBP PF02517.16 KOO25983.1 - 4.6e-09 36.5 13.5 3.3e-08 33.8 13.5 2.3 1 1 0 1 1 1 1 CPBP intramembrane metalloprotease AlaE PF06610.13 KOO25983.1 - 0.0055 16.7 0.3 0.014 15.4 0.1 1.8 2 0 0 2 2 2 1 L-alanine exporter Ribosomal_L16 PF00252.18 KOO25984.1 - 2.9e-43 147.1 0.4 4.1e-43 146.6 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DnaJ PF00226.31 KOO25985.1 - 9.4e-19 67.3 0.5 1.9e-18 66.4 0.5 1.4 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 KOO25985.1 - 3.2e-15 54.9 20.5 0.00021 21.1 0.0 7.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO25985.1 - 5.5e-15 54.5 9.8 4.3e-05 23.2 1.5 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO25985.1 - 1e-09 37.9 4.3 5e-07 29.3 0.1 4.6 3 1 1 4 4 4 2 TPR repeat TPR_16 PF13432.6 KOO25985.1 - 2.5e-07 31.2 34.8 7.9e-06 26.4 3.7 5.1 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO25985.1 - 4.7e-07 30.2 22.5 0.012 16.1 0.5 4.9 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO25985.1 - 5.8e-06 26.5 25.8 0.11 12.8 6.2 5.4 3 2 1 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOO25985.1 - 0.00023 21.7 30.5 0.064 14.1 0.1 7.6 5 1 2 8 8 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO25985.1 - 0.00064 19.6 17.0 0.0073 16.3 0.0 5.6 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO25985.1 - 0.0045 17.1 11.0 9 6.8 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO25985.1 - 0.0065 16.6 0.4 0.0065 16.6 0.4 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO25985.1 - 0.012 16.0 11.7 0.097 13.1 1.4 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat AAR2 PF05282.11 KOO25985.1 - 0.056 12.8 0.1 0.089 12.2 0.1 1.2 1 0 0 1 1 1 0 AAR2 protein TPR_6 PF13174.6 KOO25985.1 - 2.3 9.0 0.0 1.6 9.6 0.3 4.8 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO25985.1 - 3.4 8.6 15.5 1 10.2 0.1 5.2 4 0 0 4 4 3 0 Tetratricopeptide repeat PKK PF12474.8 KOO25987.1 - 0.016 15.3 3.9 0.016 15.3 3.9 1.8 1 1 1 2 2 2 0 Polo kinase kinase Fib_alpha PF08702.10 KOO25987.1 - 0.018 15.2 2.2 0.043 14.0 2.2 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family PKcGMP_CC PF16808.5 KOO25987.1 - 0.076 12.9 0.2 15 5.5 0.1 3.1 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4795 PF16043.5 KOO25987.1 - 0.5 9.9 5.9 1.5 8.4 5.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF702 PF05142.12 KOO25987.1 - 3.5 8.1 9.5 0.44 11.0 4.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF702) Nucleotid_trans PF03407.16 KOO25988.1 - 2.9e-13 50.3 0.0 5.8e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase TolA_bind_tri PF16331.5 KOO25988.1 - 0.0093 16.0 4.1 0.0093 16.0 4.1 8.6 6 2 2 8 8 8 3 TolA binding protein trimerisation Nairo_nucleo PF02477.15 KOO25988.1 - 0.14 10.9 0.5 0.46 9.3 0.5 1.8 1 0 0 1 1 1 0 Nucleocapsid N protein SHE3 PF17078.5 KOO25988.1 - 2.9 7.6 16.3 0.014 15.1 3.4 3.2 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 tRNA-synt_2d PF01409.20 KOO25990.1 - 9.6e-87 290.5 0.0 1.4e-86 289.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 KOO25990.1 - 6.3e-13 48.8 0.4 4.4e-12 46.1 0.1 2.4 2 0 0 2 2 2 1 PheRS DNA binding domain 3 PheRS_DBD1 PF18552.1 KOO25990.1 - 1.6e-07 30.9 0.7 3.2e-07 30.0 0.2 1.8 2 0 0 2 2 2 1 PheRS DNA binding domain 1 tRNA-synt_2 PF00152.20 KOO25990.1 - 0.00013 21.2 0.2 0.00023 20.3 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 KOO25990.1 - 0.00015 21.8 0.0 0.00032 20.7 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Arm PF00514.23 KOO25991.1 - 0.003 17.6 36.2 0.0095 16.0 1.4 8.1 10 0 0 10 10 10 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO25991.1 - 0.78 10.2 30.6 0.18 12.3 5.8 6.5 5 2 1 6 6 6 0 HEAT repeats HEAT_EZ PF13513.6 KOO25991.1 - 1.1 9.9 38.0 0.086 13.4 5.3 6.6 6 1 1 7 7 7 0 HEAT-like repeat 2OG-FeII_Oxy_3 PF13640.6 KOO25992.1 - 1.3e-14 54.8 0.3 3.5e-14 53.5 0.3 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CoA_transf_3 PF02515.17 KOO25993.1 - 5.2e-35 121.2 1.2 3.4e-28 98.8 0.0 2.6 2 1 0 2 2 2 2 CoA-transferase family III Ion_trans_2 PF07885.16 KOO25993.1 - 4e-14 52.3 3.0 8.6e-14 51.3 3.0 1.5 1 0 0 1 1 1 1 Ion channel DUF218 PF02698.17 KOO25994.1 - 1.5e-18 67.1 0.2 2.2e-18 66.5 0.2 1.3 1 1 0 1 1 1 1 DUF218 domain DUF4449 PF14613.6 KOO25995.1 - 0.094 12.8 4.6 0.12 12.5 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) DUF4746 PF15928.5 KOO25995.1 - 0.37 10.2 6.4 0.46 9.9 6.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF724 PF05266.14 KOO25995.1 - 0.41 10.5 6.6 0.49 10.2 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HABP4_PAI-RBP1 PF04774.15 KOO25995.1 - 2.2 9.2 10.8 2.7 8.9 10.8 1.1 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family Uso1_p115_C PF04871.13 KOO25995.1 - 2.3 8.6 13.8 2.9 8.3 13.8 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF5529 PF17669.1 KOO25996.1 - 0.032 14.3 0.3 0.032 14.3 0.3 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5529) OmpA PF00691.20 KOO25997.1 - 3.9e-20 72.0 0.1 0.0014 18.9 0.0 9.0 8 0 0 8 8 8 5 OmpA family EF-hand_1 PF00036.32 KOO25997.1 - 7.5e-10 37.6 0.2 0.00055 19.3 0.1 2.6 2 0 0 2 2 2 2 EF hand Annexin PF00191.20 KOO25997.1 - 6.4e-08 32.5 0.0 0.0011 18.9 0.0 3.1 3 0 0 3 3 3 2 Annexin EF-hand_7 PF13499.6 KOO25997.1 - 1.3e-06 28.8 0.3 2.7e-06 27.7 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO25997.1 - 4e-06 26.3 0.5 0.0067 16.3 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain DHC_N1 PF08385.12 KOO25997.1 - 4.9e-06 25.5 0.0 7.5e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 EF-hand_5 PF13202.6 KOO25997.1 - 8.8e-05 21.8 0.5 0.21 11.2 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO25997.1 - 9.6e-05 22.2 0.1 0.00019 21.2 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair Nuc_sug_transp PF04142.15 KOO25998.1 - 3.6e-60 203.8 13.2 4.3e-60 203.5 13.2 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO25998.1 - 2.5e-10 40.7 22.8 7.9e-06 26.1 6.0 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO25998.1 - 1.2e-05 24.7 17.2 0.00031 20.0 17.1 2.2 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.16 KOO25998.1 - 6.1e-05 22.5 3.6 6.1e-05 22.5 3.6 2.3 3 0 0 3 3 3 1 Triose-phosphate Transporter family DMT_6 PF04342.12 KOO25998.1 - 2.1 8.6 11.9 2.9 8.1 4.3 2.8 2 1 1 3 3 3 0 Putative member of DMT superfamily (DUF486) Nucleotid_trans PF03407.16 KOO25999.1 - 3.3e-07 30.5 0.1 6.6e-07 29.5 0.0 1.6 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF445 PF04286.12 KOO26000.1 - 5.3e-09 36.4 0.1 1.1e-06 28.7 0.0 3.3 2 2 2 4 4 4 1 Protein of unknown function (DUF445) ATP-synt_J PF04911.12 KOO26000.1 - 0.95 9.1 2.4 16 5.1 0.0 2.9 3 0 0 3 3 3 0 ATP synthase j chain PQQ_3 PF13570.6 KOO26003.1 - 2.5e-56 186.8 30.7 1.8e-07 31.4 0.1 8.1 8 0 0 8 8 8 8 PQQ-like domain PQQ PF01011.21 KOO26003.1 - 4.9e-48 158.9 15.3 1e-07 31.5 0.2 7.8 8 0 0 8 8 8 7 PQQ enzyme repeat PQQ_2 PF13360.6 KOO26003.1 - 3e-45 154.6 7.0 2.1e-24 86.4 1.7 3.1 1 1 2 3 3 3 3 PQQ-like domain ANAPC4_WD40 PF12894.7 KOO26003.1 - 8.9e-06 25.9 0.0 3.1 8.2 0.0 4.6 1 1 4 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_like PF09279.11 KOO26003.1 - 0.0014 19.1 0.0 6.5 7.3 0.0 4.6 5 1 1 6 6 5 1 Phosphoinositide-specific phospholipase C, efhand-like WD40 PF00400.32 KOO26003.1 - 0.0041 17.9 4.9 11 7.1 0.0 4.5 4 1 0 4 4 4 2 WD domain, G-beta repeat Laminin_G_2 PF02210.24 KOO26003.1 - 0.012 16.2 0.2 0.28 11.8 0.0 3.3 2 2 1 4 4 4 0 Laminin G domain BsuPI PF12690.7 KOO26003.1 - 0.017 15.1 0.0 3.3 7.8 0.0 3.5 3 0 0 3 3 3 0 Intracellular proteinase inhibitor Cytochrom_D1 PF02239.16 KOO26003.1 - 0.02 13.5 1.5 11 4.4 0.0 3.2 2 1 2 4 4 4 0 Cytochrome D1 heme domain MinC_C PF03775.16 KOO26003.1 - 0.21 11.6 0.2 26 4.9 0.0 2.8 3 1 0 3 3 3 0 Septum formation inhibitor MinC, C-terminal domain SUKH-4 PF14435.6 KOO26003.1 - 0.3 11.1 6.0 13 5.8 0.1 4.1 2 1 3 5 5 5 0 SUKH-4 immunity protein Glycolytic PF00274.19 KOO26004.1 - 7.4e-97 324.2 0.0 8.7e-97 324.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Methyltransf_21 PF05050.12 KOO26005.1 - 2.5e-06 27.6 0.0 2.5e-06 27.6 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase FkbM domain TRSP PF12500.8 KOO26005.1 - 0.11 12.3 0.2 0.83 9.6 0.0 1.9 1 1 1 2 2 2 0 TRSP domain C terminus to PRTase_2 SASA PF03629.18 KOO26006.1 - 3.2e-20 72.7 0.0 5.1e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate esterase, sialic acid-specific acetylesterase EF-hand_7 PF13499.6 KOO26007.1 - 4e-23 81.6 2.5 2e-12 47.4 1.2 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO26007.1 - 4.4e-21 72.8 9.1 9e-06 24.9 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO26007.1 - 2.7e-17 61.1 5.5 0.00069 19.4 0.3 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO26007.1 - 2.3e-12 45.8 14.1 0.00075 18.9 0.0 4.8 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO26007.1 - 3.5e-10 39.6 9.8 9e-05 22.2 1.4 3.7 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO26007.1 - 9.5e-08 32.4 0.5 0.0028 18.0 0.1 3.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO26007.1 - 1.4e-06 28.2 1.0 0.00065 19.6 0.1 3.3 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO26007.1 - 0.034 14.5 0.7 9.8 6.6 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain GAT PF03127.14 KOO26007.1 - 0.2 12.0 0.7 0.73 10.2 0.7 2.0 1 0 0 1 1 1 0 GAT domain DegT_DnrJ_EryC1 PF01041.17 KOO26008.1 - 4.7e-65 220.3 0.0 6.4e-65 219.8 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GDP_Man_Dehyd PF16363.5 KOO26008.1 - 1.2e-45 156.4 0.0 1.6e-45 156.0 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOO26008.1 - 1.2e-43 149.4 0.0 2e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 KOO26008.1 - 5.9e-18 65.0 0.0 2.2e-17 63.1 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 KOO26008.1 - 4e-12 45.8 0.0 6.4e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KOO26008.1 - 8.2e-12 44.8 0.0 4.3e-11 42.5 0.0 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 KOO26008.1 - 2.5e-10 39.8 0.0 3.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 KOO26008.1 - 0.036 14.0 0.0 0.074 12.9 0.0 1.5 1 1 0 1 1 1 0 KR domain Glyco_hydro_53 PF07745.13 KOO26009.1 - 0.011 14.8 0.0 0.013 14.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 Cas9_a PF18470.1 KOO26009.1 - 0.12 11.9 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 Cas9 alpha-helical lobe domain ABA_GPCR PF12430.8 KOO26011.1 - 5.6e-10 39.3 1.3 1.9e-09 37.6 0.0 2.2 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 KOO26011.1 - 6.6e-05 22.9 0.0 0.00015 21.8 0.0 1.6 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal Dpy19 PF10034.9 KOO26011.1 - 0.78 7.9 2.3 0.64 8.2 1.2 1.3 1 1 0 1 1 1 0 Q-cell neuroblast polarisation Ank_2 PF12796.7 KOO26013.1 - 1.4e-09 38.4 0.5 5.6e-08 33.3 0.1 2.8 1 1 2 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO26013.1 - 1.5e-09 37.9 0.3 1e-06 28.9 0.1 3.2 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO26013.1 - 6.7e-08 32.2 2.7 0.00042 20.5 0.1 4.8 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.6 KOO26013.1 - 1.7e-06 28.5 0.4 1.7e-05 25.3 0.0 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO26013.1 - 0.0016 18.8 0.2 0.0016 18.8 0.2 3.9 6 0 0 6 6 6 1 Ankyrin repeat DAGAT PF03982.13 KOO26014.1 - 1.2e-35 122.9 0.0 1.6e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Vint PF14623.6 KOO26015.1 - 1.1e-26 93.7 0.0 1.8e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 Hint-domain VWA_2 PF13519.6 KOO26015.1 - 1.8e-11 44.6 0.0 3.9e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 KOO26015.1 - 0.00041 20.6 0.0 0.00078 19.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Vwaint PF14624.6 KOO26015.1 - 0.028 14.6 0.0 0.076 13.2 0.0 1.7 2 0 0 2 2 2 0 VWA / Hh protein intein-like Hint PF01079.20 KOO26015.1 - 0.084 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Hint module Thioredoxin_4 PF13462.6 KOO26017.1 - 5.5e-05 23.4 0.0 6.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Herpes_IE1 PF07340.11 KOO26017.1 - 0.23 10.4 0.0 0.27 10.1 0.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein Tudor-knot PF11717.8 KOO26018.1 - 9.2e-19 67.1 1.1 1.7e-08 34.2 0.0 3.0 3 0 0 3 3 3 2 RNA binding activity-knot of a chromodomain TUDOR_5 PF18359.1 KOO26018.1 - 6e-10 38.7 0.9 5.3e-05 22.8 0.2 2.6 2 0 0 2 2 2 2 Histone methyltransferase Tudor domain 1 Tudor_3 PF18115.1 KOO26018.1 - 1.6e-06 27.8 0.3 0.0098 15.7 0.1 3.2 3 0 0 3 3 3 2 DNA repair protein Crb2 Tudor domain MBT PF02820.18 KOO26018.1 - 9.8e-06 25.8 0.0 0.0055 17.0 0.0 2.9 2 0 0 2 2 2 2 mbt repeat Agenet PF05641.12 KOO26018.1 - 0.0017 18.8 2.4 1.8 9.1 0.0 3.7 4 0 0 4 4 4 1 Agenet domain SAWADEE PF16719.5 KOO26018.1 - 0.0022 18.0 0.7 4.4 7.3 0.0 3.5 2 2 2 4 4 4 1 SAWADEE domain Chromo PF00385.24 KOO26018.1 - 0.026 14.4 0.1 0.91 9.5 0.0 2.4 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain Tudor_2 PF18104.1 KOO26018.1 - 0.044 13.5 5.2 0.22 11.2 0.5 2.8 3 1 0 3 3 3 0 Jumonji domain-containing protein 2A Tudor domain HAS-barrel PF09378.10 KOO26018.1 - 0.13 12.4 0.0 20 5.4 0.0 2.6 2 0 0 2 2 2 0 HAS barrel domain Metallophos PF00149.28 KOO26020.1 - 1.4e-09 38.8 0.0 1.4e-09 38.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO26020.1 - 0.061 13.5 0.0 0.095 12.9 0.0 1.5 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain RNA_pol_Rpb2_6 PF00562.28 KOO26021.1 - 2.4e-106 356.1 0.0 5.6e-106 354.9 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KOO26021.1 - 1.7e-30 106.0 0.0 3e-30 105.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 KOO26021.1 - 2.2e-18 66.4 0.0 4.8e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 KOO26021.1 - 8.3e-16 58.2 0.0 1.3e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 HTH_Tnp_1 PF01527.20 KOO26021.1 - 7e-07 29.5 0.0 1.7e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Transposase RNA_pol_Rpb2_3 PF04565.16 KOO26021.1 - 8.9e-05 22.6 0.1 0.0002 21.5 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 DUF2475 PF10629.9 KOO26022.1 - 0.00016 21.8 6.9 0.036 14.3 0.1 3.3 4 0 0 4 4 4 2 Protein of unknown function (DUF2475) Snf7 PF03357.21 KOO26023.1 - 1e-21 77.3 32.1 3.8e-12 46.2 7.2 4.3 3 2 1 4 4 4 2 Snf7 DUF3656 PF12392.8 KOO26023.1 - 0.14 12.8 4.4 0.59 10.8 0.5 2.7 2 0 0 2 2 2 0 Collagenase Hydantoinase_B PF02538.14 KOO26023.1 - 0.32 9.3 2.5 0.49 8.8 1.7 1.6 1 1 1 2 2 2 0 Hydantoinase B/oxoprolinase NRBF2_MIT PF17169.4 KOO26023.1 - 1 9.6 14.6 0.94 9.7 2.4 2.9 3 0 0 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 TPR_11 PF13414.6 KOO26025.1 - 0.00017 21.2 9.7 0.37 10.5 0.0 4.3 4 0 0 4 4 4 3 TPR repeat TPR_2 PF07719.17 KOO26025.1 - 0.00038 20.3 11.6 0.59 10.4 1.6 4.3 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26025.1 - 0.0061 16.3 12.4 5.8 6.9 2.1 5.3 4 2 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO26025.1 - 0.13 13.2 10.3 0.93 10.5 0.0 4.0 1 1 2 4 4 4 0 Tetratricopeptide repeat LVIVD PF08309.11 KOO26026.1 - 3.1e-38 128.8 59.6 1.5e-10 40.2 3.9 7.3 6 1 1 7 7 7 7 LVIVD repeat SBP56 PF05694.11 KOO26026.1 - 0.006 15.5 0.1 0.97 8.2 0.0 2.6 1 1 2 3 3 3 2 56kDa selenium binding protein (SBP56) Chitin_bind_4 PF00379.23 KOO26026.1 - 0.046 14.3 19.9 30 5.3 0.1 7.1 7 0 0 7 7 7 0 Insect cuticle protein PSCyt3 PF07627.11 KOO26026.1 - 0.14 12.4 0.1 20 5.5 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1588) DUF150_C PF17384.2 KOO26027.1 - 2.7e-06 27.4 0.0 4.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 RimP C-terminal SH3 domain Methyltr_RsmB-F PF01189.17 KOO26028.1 - 7.6e-05 22.4 0.0 0.00043 20.0 0.0 1.9 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Bestrophin PF01062.21 KOO26029.1 - 1.1e-15 57.8 2.3 1.6e-15 57.3 2.3 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel PARP PF00644.20 KOO26031.1 - 4.9e-11 42.6 0.1 2.7e-10 40.2 0.0 1.9 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PP-binding PF00550.25 KOO26032.1 - 4.3e-05 23.8 0.0 8.1e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site IBR PF01485.21 KOO26035.1 - 0.16 12.2 5.0 0.35 11.1 5.0 1.6 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain DUF630 PF04783.12 KOO26035.1 - 0.39 10.9 3.4 0.26 11.5 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF630) Kinesin PF00225.23 KOO26037.1 - 3.5e-88 295.7 0.0 6.3e-88 294.9 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO26037.1 - 3.1e-18 66.1 0.0 6.1e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding TPR_12 PF13424.6 KOO26037.1 - 0.032 14.5 0.2 0.11 12.8 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_16 PF13191.6 KOO26037.1 - 0.047 14.1 2.0 0.1 13.0 0.1 2.4 2 1 0 2 2 2 0 AAA ATPase domain TruB_C PF09142.11 KOO26037.1 - 0.067 13.0 0.2 3.5 7.5 0.1 2.7 1 1 1 2 2 2 0 tRNA Pseudouridine synthase II, C terminal AAA_22 PF13401.6 KOO26037.1 - 0.12 12.6 1.6 0.23 11.7 0.2 2.2 2 0 0 2 2 2 0 AAA domain Cpn60_TCP1 PF00118.24 KOO26038.1 - 5.3e-149 497.0 13.2 6.1e-149 496.8 13.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family 2OG-FeII_Oxy_3 PF13640.6 KOO26040.1 - 6.4e-14 52.6 0.0 9.8e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 KOO26041.1 - 2.3e-23 82.7 31.3 2.3e-23 82.7 31.3 2.3 1 1 2 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO26041.1 - 1.8e-06 27.1 1.6 1.8e-06 27.1 1.6 2.6 1 1 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 KOO26041.1 - 1.2e-05 24.3 0.9 1.2e-05 24.3 0.9 2.8 2 1 1 3 3 3 1 MFS_1 like family OATP PF03137.20 KOO26041.1 - 0.63 8.3 4.7 1.8 6.8 2.0 2.5 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family zf-C3HC4_3 PF13920.6 KOO26042.1 - 1.7e-08 34.2 11.7 2.7e-08 33.5 11.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Arm PF00514.23 KOO26042.1 - 0.00016 21.6 0.1 0.45 10.6 0.0 2.6 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Prok-RING_4 PF14447.6 KOO26042.1 - 1.1 9.1 13.2 2.3 8.2 13.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Glyco_transf_34 PF05637.12 KOO26043.1 - 5.5e-26 91.7 0.2 3.1e-13 50.0 0.2 3.1 1 1 2 3 3 3 3 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 KOO26043.1 - 0.00064 19.3 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF273 Nucleotid_trans PF03407.16 KOO26043.1 - 0.0034 17.4 0.0 0.0061 16.6 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Csm1_N PF18504.1 KOO26043.1 - 0.015 15.6 0.0 0.031 14.6 0.0 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain Muted PF14942.6 KOO26043.1 - 0.054 13.8 0.7 0.09 13.1 0.7 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein NIF PF03031.18 KOO26044.1 - 1.7e-22 79.9 0.0 2.3e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.12 KOO26044.1 - 0.00085 18.9 0.0 0.012 15.1 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF705) HisKA_3 PF07730.13 KOO26044.1 - 0.056 14.0 0.1 43 4.7 0.1 3.4 3 0 0 3 3 3 0 Histidine kinase BTB PF00651.31 KOO26045.1 - 1.2e-24 86.7 0.0 1.8e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 KOO26045.1 - 4.1e-18 65.4 0.0 1.6e-17 63.5 0.0 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Arm PF00514.23 KOO26046.1 - 0.0092 16.0 11.4 0.17 11.9 1.6 5.4 4 3 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KOO26046.1 - 0.071 13.4 3.2 2.8 8.4 0.1 4.1 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 KOO26046.1 - 0.22 12.1 6.7 2.2 8.9 0.3 4.4 3 1 1 4 4 4 0 HEAT-like repeat PTR2 PF00854.21 KOO26047.1 - 3.8e-45 154.4 4.4 2.5e-23 82.6 3.0 2.2 2 0 0 2 2 2 2 POT family MFS_1 PF07690.16 KOO26047.1 - 4.4e-16 58.7 13.4 4.4e-16 58.7 13.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Pyr_redox_2 PF07992.14 KOO26048.1 - 3.5e-35 121.7 0.0 5.1e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOO26048.1 - 4.2e-26 91.4 0.0 6.3e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOO26048.1 - 7e-13 49.0 3.1 2.5e-09 37.6 0.0 2.8 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOO26048.1 - 4.7e-09 35.8 0.3 0.0016 17.8 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 KOO26048.1 - 2.5e-06 26.9 0.1 5.3e-06 25.8 0.0 1.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 KOO26048.1 - 3.3e-06 26.9 6.7 4.1e-05 23.3 1.0 2.6 2 1 1 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 KOO26048.1 - 1.3e-05 24.5 2.5 0.00022 20.5 0.8 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 KOO26048.1 - 9e-05 21.7 6.2 0.0012 18.0 0.8 2.9 3 0 0 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 KOO26048.1 - 0.00018 21.0 1.2 0.00027 20.4 1.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KOO26048.1 - 0.00019 20.8 0.2 0.25 10.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOO26048.1 - 0.00038 20.6 7.2 0.065 13.5 0.7 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KOO26048.1 - 0.0013 17.5 1.5 0.0035 16.1 0.2 2.2 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_7 PF13241.6 KOO26048.1 - 0.0033 17.8 0.2 0.076 13.5 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding XdhC_C PF13478.6 KOO26048.1 - 0.0042 17.6 0.1 0.96 10.0 0.0 2.6 2 0 0 2 2 2 1 XdhC Rossmann domain Thi4 PF01946.17 KOO26048.1 - 0.0078 15.5 2.3 0.054 12.7 0.2 2.6 3 0 0 3 3 3 1 Thi4 family FAD_binding_3 PF01494.19 KOO26048.1 - 0.069 12.4 4.1 1.3 8.2 0.1 2.7 3 0 0 3 3 3 0 FAD binding domain Lycopene_cycl PF05834.12 KOO26048.1 - 0.11 11.5 0.5 0.22 10.5 0.5 1.7 1 1 0 1 1 1 0 Lycopene cyclase protein Kelch_1 PF01344.25 KOO26048.1 - 0.54 9.9 2.1 2.5 7.7 0.3 2.9 3 0 0 3 3 3 0 Kelch motif UDPG_MGDP_dh_N PF03721.14 KOO26048.1 - 2.5 7.6 5.3 0.37 10.4 0.4 1.9 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SHNi-TPR PF10516.9 KOO26049.1 - 6.6e-08 31.9 0.0 1.5e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 SHNi-TPR DUF3506 PF12014.8 KOO26050.1 - 2e-05 24.6 0.2 0.0012 18.9 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF3506) DUF2880 PF11082.8 KOO26050.1 - 0.038 14.3 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2880) EF-hand_6 PF13405.6 KOO26053.1 - 1.7e-10 40.0 6.9 0.0013 18.5 0.1 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KOO26053.1 - 5.1e-10 39.0 0.9 0.001 18.9 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO26053.1 - 3.9e-09 35.4 6.8 0.0017 17.8 0.3 4.2 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KOO26053.1 - 3.3e-08 33.8 6.9 0.00018 21.9 0.1 3.5 2 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO26053.1 - 0.00039 19.8 2.1 0.033 13.7 0.1 3.4 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 KOO26053.1 - 0.041 14.2 0.1 22 5.5 0.0 3.4 3 0 0 3 3 3 0 EF-hand domain TMF_DNA_bd PF12329.8 KOO26053.1 - 0.048 13.7 1.1 0.048 13.7 1.1 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Dak2 PF02734.17 KOO26053.1 - 0.22 11.4 4.7 0.18 11.7 2.5 1.9 1 1 1 2 2 2 0 DAK2 domain GspL_C PF12693.7 KOO26053.1 - 0.28 11.0 3.1 0.36 10.7 0.0 2.5 2 1 1 3 3 3 0 GspL periplasmic domain DUF1840 PF08895.11 KOO26053.1 - 0.32 11.3 4.2 1.8 8.9 0.7 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1840) DUF2203 PF09969.9 KOO26053.1 - 0.55 11.0 6.2 6.1 7.6 1.2 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Syntaxin PF00804.25 KOO26053.1 - 1.2 8.8 7.4 10 5.7 2.4 2.2 2 0 0 2 2 2 0 Syntaxin OmpH PF03938.14 KOO26053.1 - 2.1 8.7 8.0 12 6.3 3.9 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Uso1_p115_C PF04871.13 KOO26053.1 - 5.8 7.3 11.6 6.5 7.1 1.1 2.4 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Peptidase_S41 PF03572.18 KOO26054.1 - 1.1e-37 129.2 0.0 1.5e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S41 PDZ_6 PF17820.1 KOO26054.1 - 1.2e-07 31.4 0.1 3.7e-07 29.9 0.1 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KOO26054.1 - 5e-06 26.8 0.2 6e-05 23.3 0.1 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO26054.1 - 0.00031 21.0 0.2 0.0007 19.9 0.2 1.5 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KOO26054.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 Tricorn protease PDZ domain C2 PF00168.30 KOO26055.1 - 3e-14 53.1 0.0 2.5e-13 50.2 0.0 2.2 1 1 0 1 1 1 1 C2 domain EccE PF11203.8 KOO26056.1 - 0.023 15.0 8.7 0.89 9.9 1.9 3.0 1 1 1 2 2 2 0 Putative type VII ESX secretion system translocon, EccE DUF4726 PF15855.5 KOO26056.1 - 0.037 14.2 0.1 0.088 13.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4726) GntR PF00392.21 KOO26056.1 - 0.07 12.8 1.4 6 6.6 0.0 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, gntR family Nha1_C PF08619.10 KOO26057.1 - 0.1 11.8 7.2 0.13 11.4 7.2 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus SdpI PF13630.6 KOO26058.1 - 0.00034 20.7 8.6 0.0024 18.0 0.5 3.3 3 1 0 3 3 3 2 SdpI/YhfL protein family COX15-CtaA PF02628.15 KOO26058.1 - 0.0021 17.2 1.6 0.29 10.2 0.1 2.4 2 0 0 2 2 2 2 Cytochrome oxidase assembly protein DUF2427 PF10348.9 KOO26058.1 - 0.016 15.0 8.1 1.4 8.8 0.1 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF2427) Cytochrom_C_asm PF01578.20 KOO26058.1 - 0.056 13.2 1.0 0.095 12.4 1.0 1.4 1 1 0 1 1 1 0 Cytochrome C assembly protein DUF4079 PF13301.6 KOO26058.1 - 0.089 12.9 1.4 0.32 11.1 1.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) DUF2306 PF10067.9 KOO26058.1 - 0.29 11.3 5.7 2.7 8.2 0.2 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2306) DUF2975 PF11188.8 KOO26058.1 - 1.6 8.6 6.5 3.6 7.5 1.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) VWA PF00092.28 KOO26061.1 - 1e-08 35.7 0.0 4.1e-08 33.7 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain SecA_DEAD PF07517.14 KOO26061.1 - 1.1e-07 31.5 0.1 7.7e-07 28.7 0.0 2.5 3 0 0 3 3 3 1 SecA DEAD-like domain VWA_2 PF13519.6 KOO26061.1 - 7e-07 29.9 0.0 5.5e-06 27.0 0.0 2.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Tim29 PF10171.9 KOO26061.1 - 0.0011 18.4 0.0 0.0031 17.0 0.0 1.7 1 0 0 1 1 1 1 Translocase of the Inner Mitochondrial membrane 29 MMR_HSR1 PF01926.23 KOO26061.1 - 0.0032 17.5 0.0 0.013 15.6 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase EspB_PE PF18625.1 KOO26061.1 - 0.0058 17.1 2.9 0.12 12.9 0.0 4.1 2 0 0 2 2 2 1 ESX-1 secreted protein B PE domain RNA_helicase PF00910.22 KOO26061.1 - 0.026 14.9 0.0 0.63 10.5 0.0 3.0 3 0 0 3 3 3 0 RNA helicase AAA_23 PF13476.6 KOO26061.1 - 0.049 14.1 0.0 0.25 11.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOO26061.1 - 0.089 12.5 0.0 0.3 10.9 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO26061.1 - 0.17 11.8 0.0 0.44 10.4 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Glyco_transf_25 PF01755.17 KOO26062.1 - 3.1e-20 72.9 0.0 8.9e-20 71.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Hint PF01079.20 KOO26064.1 - 2.7e-22 79.3 0.1 4.5e-22 78.6 0.1 1.2 1 0 0 1 1 1 1 Hint module YHYH PF14240.6 KOO26064.1 - 6.3e-19 68.7 20.8 1.3e-15 57.8 0.5 3.9 2 2 2 4 4 4 2 YHYH protein Vint PF14623.6 KOO26064.1 - 0.027 14.3 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 Hint-domain DUF3449 PF11931.8 KOO26066.1 - 9e-73 244.0 0.0 1.3e-72 243.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) Telomere_Sde2_2 PF13297.6 KOO26066.1 - 2.6e-23 81.4 1.8 2.8e-23 81.3 0.6 1.8 2 0 0 2 2 2 1 Telomere stability C-terminal SF3A3 PF16837.5 KOO26066.1 - 2e-22 79.5 0.0 3.9e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 KOO26066.1 - 2.4e-07 30.5 0.1 4.6e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain tRNA_bind PF01588.20 KOO26067.1 - 1.4e-28 98.8 0.1 3.2e-28 97.7 0.0 1.6 2 0 0 2 2 2 1 Putative tRNA binding domain GST_C_2 PF13410.6 KOO26067.1 - 2.4e-07 30.7 0.1 4.2e-07 29.9 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOO26067.1 - 0.033 14.4 0.0 0.065 13.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Fer2 PF00111.27 KOO26068.1 - 5.9e-18 64.6 3.8 1.2e-17 63.6 1.8 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain HHV-1_VABD PF16852.5 KOO26068.1 - 0.031 14.3 0.0 0.082 12.9 0.0 1.7 1 0 0 1 1 1 0 Herpes viral adaptor-to-host cellular mRNA binding domain Pro_CA PF00484.19 KOO26069.1 - 1.5e-12 48.1 0.0 1.9e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Carbonic anhydrase RCC1 PF00415.18 KOO26070.1 - 3.6e-48 162.0 32.1 8e-14 52.0 0.1 8.8 8 2 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO26070.1 - 2.7e-28 97.1 29.8 1.2e-08 34.5 1.8 6.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat PapC_C PF13953.6 KOO26070.1 - 0.0033 17.2 0.2 4.9 7.0 0.0 3.2 3 0 0 3 3 3 2 PapC C-terminal domain Hira PF07569.11 KOO26070.1 - 0.009 15.8 0.0 0.89 9.2 0.0 2.8 3 1 1 4 4 4 1 TUP1-like enhancer of split Kelch_6 PF13964.6 KOO26070.1 - 0.87 10.0 3.2 6.6 7.2 0.1 3.8 5 0 0 5 5 5 0 Kelch motif AAA PF00004.29 KOO26071.1 - 6e-18 65.5 0.0 8e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 KOO26071.1 - 7e-05 22.9 0.3 9.7e-05 22.4 0.3 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA_16 PF13191.6 KOO26071.1 - 0.00078 19.9 0.1 0.0017 18.7 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 KOO26071.1 - 0.002 17.7 0.0 0.006 16.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO26071.1 - 0.0029 17.8 0.0 0.0039 17.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 KOO26071.1 - 0.014 14.5 0.0 0.019 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 KOO26071.1 - 0.038 13.7 0.0 0.055 13.2 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 KOO26071.1 - 0.041 14.3 0.0 0.068 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 KOO26071.1 - 0.044 13.8 0.0 0.093 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 KOO26071.1 - 0.049 13.0 0.0 0.076 12.3 0.0 1.2 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.6 KOO26071.1 - 0.051 13.8 0.1 0.1 12.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 KOO26071.1 - 0.057 13.3 0.0 0.098 12.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain NACHT PF05729.12 KOO26071.1 - 0.068 13.1 0.0 0.22 11.4 0.0 1.8 2 1 0 2 2 2 0 NACHT domain ABC_tran PF00005.27 KOO26071.1 - 0.091 13.3 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 KOO26071.1 - 0.1 12.4 0.0 0.4 10.5 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain OTU PF02338.19 KOO26072.1 - 5.3e-10 39.9 0.0 7.5e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease PsbM PF05151.12 KOO26073.1 - 0.00011 21.9 1.7 0.00011 21.9 1.7 1.8 2 0 0 2 2 2 1 Photosystem II reaction centre M protein (PsbM) Stevor PF17410.2 KOO26073.1 - 1.7 8.1 3.4 2 7.9 3.4 1.0 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame PrmA PF06325.13 KOO26074.1 - 1.9e-07 30.8 0.0 3.4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KOO26074.1 - 8.1e-06 26.5 0.4 0.0002 22.0 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO26074.1 - 1.3e-05 25.0 0.0 0.0005 19.9 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO26074.1 - 0.00019 22.0 0.2 0.054 14.2 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 KOO26074.1 - 0.0029 17.4 0.1 0.011 15.5 0.0 1.8 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 KOO26074.1 - 0.011 16.8 0.4 0.33 12.0 0.0 3.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_16 PF10294.9 KOO26074.1 - 0.013 15.3 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 Lysine methyltransferase Methyltransf_23 PF13489.6 KOO26074.1 - 0.018 14.9 0.0 0.19 11.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOO26074.1 - 0.021 15.6 0.0 0.13 13.1 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.6 KOO26074.1 - 0.032 14.2 0.0 0.083 12.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOO26074.1 - 0.036 13.6 0.0 0.079 12.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain adh_short_C2 PF13561.6 KOO26076.1 - 2.4e-55 187.7 3.2 3e-55 187.3 3.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO26076.1 - 1.6e-47 161.5 1.3 1.9e-47 161.2 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOO26076.1 - 3.4e-07 30.4 1.2 4.9e-07 29.8 1.2 1.2 1 0 0 1 1 1 1 KR domain Coatomer_WDAD PF04053.14 KOO26077.1 - 5.6e-127 424.5 0.0 7.7e-127 424.0 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 KOO26077.1 - 6.6e-122 407.2 0.0 1e-121 406.5 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 KOO26077.1 - 1.2e-46 155.7 14.3 6e-09 36.4 0.1 8.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO26077.1 - 1.2e-09 38.4 1.7 0.0025 18.1 0.2 5.5 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOO26077.1 - 0.024 13.3 4.5 1.5 7.3 0.1 3.3 2 1 1 3 3 3 0 Nucleoporin Nup120/160 zf-LSD1 PF06943.12 KOO26077.1 - 0.074 12.9 0.2 0.22 11.4 0.2 1.9 1 0 0 1 1 1 0 LSD1 zinc finger Nucleoporin_N PF08801.11 KOO26077.1 - 0.2 10.4 0.2 6.9 5.3 0.0 2.8 2 1 1 3 3 3 0 Nup133 N terminal like PAN_4 PF14295.6 KOO26079.1 - 4.9 7.1 11.1 1.4 8.9 2.6 2.7 3 0 0 3 3 3 0 PAN domain bZIP_1 PF00170.21 KOO26080.1 - 0.96 9.6 4.3 2.2 8.4 4.3 1.6 1 0 0 1 1 1 0 bZIP transcription factor RabGAP-TBC PF00566.18 KOO26081.1 - 1.1e-08 35.0 0.0 1.5e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PIP5K PF01504.18 KOO26082.1 - 0.04 13.1 0.0 0.048 12.9 0.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Kelch_4 PF13418.6 KOO26083.1 - 2e-35 120.5 4.3 4.7e-09 36.1 0.0 6.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KOO26083.1 - 2.2e-34 117.1 3.1 2.2e-08 34.2 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO26083.1 - 3.1e-28 97.3 4.9 6.2e-08 32.5 0.1 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 KOO26083.1 - 3.9e-22 77.7 7.8 1.1e-05 25.5 0.0 5.6 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KOO26083.1 - 1.2e-14 53.5 15.9 0.00018 21.4 0.0 6.3 5 2 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 KOO26083.1 - 2.7e-12 46.1 10.7 1.8e-06 27.4 0.0 5.9 5 2 0 5 5 5 3 Kelch motif FoP_duplication PF13865.6 KOO26083.1 - 0.34 11.5 5.3 0.66 10.6 5.3 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Radial_spoke PF04712.12 KOO26084.1 - 6.3e-87 292.6 0.0 1.6e-54 185.7 0.2 2.1 1 1 1 2 2 2 2 Radial spokehead-like protein DDE_Tnp_IS66_C PF13817.6 KOO26084.1 - 0.05 13.8 0.1 2.3 8.5 0.0 2.5 2 0 0 2 2 2 0 IS66 C-terminal element ABC_tran PF00005.27 KOO26086.1 - 5.2e-29 101.5 0.0 9.9e-20 71.5 0.0 3.0 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 KOO26086.1 - 1.1e-16 60.7 4.1 2.7e-16 59.3 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 KOO26086.1 - 8.2e-12 45.5 0.1 0.029 14.2 0.0 3.2 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO26086.1 - 2.2e-08 33.8 0.0 0.0012 18.3 0.0 3.2 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOO26086.1 - 2.3e-07 30.5 0.0 0.021 14.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 KOO26086.1 - 1.6e-06 28.8 2.1 0.057 13.9 0.0 3.1 4 0 0 4 4 3 2 AAA domain NACHT PF05729.12 KOO26086.1 - 7e-05 22.8 0.0 0.39 10.6 0.0 2.7 2 1 0 2 2 2 2 NACHT domain AAA_16 PF13191.6 KOO26086.1 - 0.0001 22.8 0.3 0.62 10.4 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 KOO26086.1 - 0.00013 21.8 0.0 0.49 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 KOO26086.1 - 0.00057 20.3 0.0 0.75 10.2 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KOO26086.1 - 0.0022 18.3 0.0 1.7 8.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO26086.1 - 0.0028 17.9 0.0 4.3 7.6 0.0 3.0 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 KOO26086.1 - 0.0033 16.7 0.2 0.67 9.1 0.0 3.4 4 1 0 4 4 4 1 NB-ARC domain Dynamin_N PF00350.23 KOO26086.1 - 0.004 17.2 0.2 0.2 11.7 0.0 3.0 3 1 0 3 3 3 1 Dynamin family RsgA_GTPase PF03193.16 KOO26086.1 - 0.005 16.8 0.0 2.9 7.8 0.0 2.8 3 0 0 3 3 3 1 RsgA GTPase MMR_HSR1 PF01926.23 KOO26086.1 - 0.005 16.9 0.3 4.7 7.3 0.0 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase DUF4853 PF16145.5 KOO26086.1 - 0.0072 16.5 0.1 1.7 8.8 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4853) AAA_5 PF07728.14 KOO26086.1 - 0.018 15.1 0.0 4.2 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KOO26086.1 - 0.019 14.5 0.0 0.28 10.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KOO26086.1 - 0.021 15.4 0.4 5.4 7.6 0.0 2.7 3 0 0 3 3 2 0 AAA domain Roc PF08477.13 KOO26086.1 - 0.022 15.0 0.0 8.1 6.7 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_27 PF13514.6 KOO26086.1 - 0.022 14.3 0.0 5.2 6.6 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KOO26086.1 - 0.022 14.2 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region DAP3 PF10236.9 KOO26086.1 - 0.024 13.8 0.0 0.84 8.7 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 KOO26086.1 - 0.065 13.6 0.0 3.6 8.0 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 KOO26086.1 - 0.079 13.1 0.0 2.2 8.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 KOO26086.1 - 0.082 12.6 0.0 6.1 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 KOO26086.1 - 0.1 12.6 0.0 4.8 7.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain DnaJ PF00226.31 KOO26087.1 - 7.4e-11 42.0 0.0 1.5e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain HSP70 PF00012.20 KOO26087.1 - 1.8 6.6 7.8 3.2 5.8 7.8 1.3 1 0 0 1 1 1 0 Hsp70 protein EF-hand_7 PF13499.6 KOO26088.1 - 2e-05 24.9 0.1 0.00017 22.0 0.2 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO26088.1 - 0.005 16.3 0.0 0.51 10.0 0.0 3.1 3 0 0 3 3 3 1 EF hand Ins_allergen_rp PF06757.13 KOO26088.1 - 0.0052 16.8 0.0 0.0095 15.9 0.0 1.4 1 0 0 1 1 1 1 Insect allergen related repeat, nitrile-specifier detoxification EF-hand_6 PF13405.6 KOO26088.1 - 0.016 15.1 0.0 0.1 12.6 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain DUF4872 PF16169.5 KOO26088.1 - 0.12 12.1 0.4 0.31 10.8 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4872) His_Phos_1 PF00300.22 KOO26089.1 - 1.1e-12 48.1 0.4 5.6e-06 26.2 0.0 3.9 3 1 1 4 4 4 3 Histidine phosphatase superfamily (branch 1) C2 PF00168.30 KOO26089.1 - 1.5e-06 28.5 0.0 2.6e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 C2 domain TauD PF02668.16 KOO26090.1 - 3.1e-32 112.4 0.0 4.8e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 KOO26090.1 - 0.00058 19.1 0.0 0.00092 18.4 0.0 1.2 1 0 0 1 1 1 1 CsiD Glyco_hydro_20 PF00728.22 KOO26091.1 - 7.5e-76 255.8 2.5 3.5e-75 253.6 2.5 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Pyrophosphatase PF00719.19 KOO26091.1 - 1.1e-42 145.6 0.1 2.1e-42 144.7 0.1 1.5 1 0 0 1 1 1 1 Inorganic pyrophosphatase Glycohydro_20b2 PF14845.6 KOO26091.1 - 8.1e-15 55.7 0.0 5.6e-14 53.0 0.0 2.3 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Fasciclin PF02469.22 KOO26094.1 - 3.2e-09 37.1 0.0 6.1e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Fasciclin domain LRR_6 PF13516.6 KOO26095.1 - 1.3e-08 34.2 10.8 1.1 9.4 0.0 8.3 9 0 0 9 9 9 4 Leucine Rich repeat LRR_4 PF12799.7 KOO26095.1 - 0.019 15.4 0.7 4.3 7.9 0.0 4.1 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) Skp1 PF01466.19 KOO26095.1 - 0.024 14.7 0.0 0.082 13.0 0.0 1.9 2 0 0 2 2 2 0 Skp1 family, dimerisation domain LRR_1 PF00560.33 KOO26095.1 - 0.078 13.6 0.0 2.1e+02 3.1 0.0 4.9 5 0 0 5 5 5 0 Leucine Rich Repeat Cupin_2 PF07883.11 KOO26096.1 - 7.2e-07 28.8 1.0 0.003 17.3 0.8 2.6 2 1 0 2 2 2 2 Cupin domain Cupin_1 PF00190.22 KOO26096.1 - 0.0028 17.3 0.0 0.044 13.4 0.0 2.3 2 0 0 2 2 2 1 Cupin AraC_binding PF02311.19 KOO26096.1 - 0.035 14.0 0.2 7.4 6.5 0.0 3.1 3 0 0 3 3 3 0 AraC-like ligand binding domain MFS_1 PF07690.16 KOO26098.1 - 1.4e-24 86.7 28.7 1.4e-24 86.7 28.7 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Pkinase PF00069.25 KOO26100.1 - 4.6e-34 118.0 0.0 7.3e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO26100.1 - 1.2e-13 51.0 0.0 1.2e-11 44.4 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase ANTH PF07651.16 KOO26100.1 - 5.7e-05 22.3 0.6 9.9e-05 21.5 0.6 1.4 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 KOO26100.1 - 0.0023 18.0 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 ENTH domain APH PF01636.23 KOO26100.1 - 0.003 17.5 1.0 0.011 15.7 0.0 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO26100.1 - 0.003 16.9 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 KOO26100.1 - 0.0077 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Cupin_8 PF13621.6 KOO26101.1 - 2.3e-07 30.8 0.4 0.00096 18.9 0.2 2.6 2 1 0 2 2 2 2 Cupin-like domain JmjC PF02373.22 KOO26101.1 - 7.1e-05 23.2 0.1 0.00018 21.9 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 KOO26101.1 - 0.074 12.5 0.2 0.12 11.8 0.2 1.2 1 0 0 1 1 1 0 Cupin superfamily protein DnaJ PF00226.31 KOO26102.1 - 3.8e-17 62.2 0.0 6.3e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain CIA30 PF08547.12 KOO26102.1 - 0.0025 17.9 0.0 0.98 9.4 0.0 2.5 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) DUF4775 PF16001.5 KOO26102.1 - 0.026 14.0 0.2 0.033 13.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) VCBS PF13517.6 KOO26104.1 - 1.3e-26 93.0 15.6 9.8e-07 29.3 0.2 7.0 5 3 3 8 8 8 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UnbV_ASPIC PF07593.12 KOO26104.1 - 1.9e-17 63.0 0.1 3.4e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 ASPIC and UnbV FG-GAP PF01839.23 KOO26104.1 - 1.1e-11 44.6 13.4 0.0043 17.2 0.0 5.8 5 0 0 5 5 5 4 FG-GAP repeat EF-hand_1 PF00036.32 KOO26104.1 - 3.8 7.3 8.9 50 3.8 0.0 4.9 5 0 0 5 5 5 0 EF hand ATP-synt_10 PF05176.14 KOO26105.1 - 1.8e-12 47.0 0.0 2.3e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein RapA_C PF12137.8 KOO26105.1 - 0.014 14.5 0.3 0.024 13.7 0.3 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Rotamase PF00639.21 KOO26106.1 - 4.1e-15 56.5 0.0 1.1e-14 55.1 0.0 1.6 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOO26106.1 - 8.5e-10 39.2 0.0 1.1e-09 38.8 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 KOO26106.1 - 0.0015 19.4 0.0 0.0023 18.7 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Fe-S_biosyn PF01521.20 KOO26108.1 - 2.3e-16 60.0 0.0 2.9e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis ABC_tran PF00005.27 KOO26109.1 - 5.1e-31 108.0 0.0 1.8e-30 106.3 0.0 2.0 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOO26109.1 - 1.8e-06 27.6 0.0 1e-05 25.1 0.1 1.5 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 KOO26109.1 - 0.00086 18.6 0.0 0.003 16.9 0.0 1.9 1 0 0 1 1 1 1 Zeta toxin SbcCD_C PF13558.6 KOO26109.1 - 0.0054 16.9 0.3 0.053 13.7 0.3 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Rad17 PF03215.15 KOO26109.1 - 0.035 14.0 0.0 0.086 12.8 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain ABC_ATPase PF09818.9 KOO26109.1 - 0.051 12.4 0.0 0.11 11.2 0.0 1.5 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_16 PF13191.6 KOO26109.1 - 0.067 13.6 1.4 0.65 10.4 0.2 3.2 2 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 KOO26109.1 - 0.079 13.4 0.7 2.2 8.7 0.1 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOO26109.1 - 0.096 12.4 1.0 0.37 10.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF2407 PF10302.9 KOO26109.1 - 0.11 13.0 2.0 1.2 9.8 0.3 2.8 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain AAA_22 PF13401.6 KOO26109.1 - 1.3 9.3 4.0 3.1 8.1 0.5 3.2 3 1 0 3 3 3 0 AAA domain ABC1 PF03109.16 KOO26110.1 - 2.7e-18 66.3 0.0 6.1e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 ABC1 family His_Phos_1 PF00300.22 KOO26111.1 - 5.3e-21 75.2 0.1 1.3e-20 73.9 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) DUF4336 PF14234.6 KOO26112.1 - 1e-52 179.3 0.0 9.4e-41 140.0 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4336) PfkB PF00294.24 KOO26114.1 - 2.2e-09 37.0 0.0 2.8e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Dus PF01207.17 KOO26115.1 - 3.6e-59 200.4 0.3 8.3e-59 199.2 0.2 1.5 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) NMO PF03060.15 KOO26115.1 - 0.0017 17.8 1.3 0.0028 17.1 1.3 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 KOO26115.1 - 0.0067 15.8 0.8 0.01 15.1 0.8 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 KOO26115.1 - 0.014 14.9 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein SOR_SNZ PF01680.17 KOO26115.1 - 0.09 12.5 3.1 0.25 11.1 1.3 2.1 1 1 1 2 2 2 0 SOR/SNZ family Oxidored_FMN PF00724.20 KOO26115.1 - 0.17 11.2 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family G3P_antiterm PF04309.12 KOO26115.1 - 0.2 11.1 0.1 0.31 10.4 0.1 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator Nuc_sug_transp PF04142.15 KOO26117.1 - 7.8e-95 317.7 11.5 8.8e-95 317.5 11.5 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO26117.1 - 0.0018 18.4 7.1 0.0018 18.4 7.1 2.3 2 0 0 2 2 2 1 EamA-like transporter family EF-hand_1 PF00036.32 KOO26118.1 - 1.3e-15 55.7 0.7 3.8e-09 35.4 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO26118.1 - 7.4e-14 52.0 0.2 1.5e-13 51.0 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO26118.1 - 1.6e-12 47.1 1.2 4.8e-11 42.3 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO26118.1 - 2.7e-10 39.3 0.3 6.8e-08 31.8 0.1 3.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO26118.1 - 5.8e-08 31.9 0.3 4.9e-06 25.8 0.1 2.6 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.9 KOO26118.1 - 0.002 18.5 0.0 0.0036 17.6 0.0 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO26118.1 - 0.043 14.7 0.0 0.092 13.6 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain DUF5580 PF17743.1 KOO26118.1 - 0.2 10.1 0.0 0.3 9.6 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) 2OG-FeII_Oxy_3 PF13640.6 KOO26119.1 - 8.6e-15 55.4 0.0 1.6e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO26119.1 - 4.3e-13 49.6 31.4 6.8e-07 29.7 2.3 4.7 4 1 0 4 4 4 4 ShK domain-like zf-CCCH PF00642.24 KOO26119.1 - 0.0088 15.9 1.0 3 7.8 0.0 2.9 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Filamin PF00630.19 KOO26120.1 - 2.6e-05 25.0 0.0 0.00011 23.0 0.0 1.9 2 0 0 2 2 2 1 Filamin/ABP280 repeat Ank_2 PF12796.7 KOO26121.1 - 8.5e-18 64.7 0.0 1.8e-10 41.2 0.0 3.0 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) EF-hand_1 PF00036.32 KOO26121.1 - 2.1e-11 42.5 2.6 0.00014 21.2 0.2 2.9 2 0 0 2 2 2 2 EF hand Ank PF00023.30 KOO26121.1 - 2.2e-11 43.7 0.3 2.8e-05 24.4 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 KOO26121.1 - 2.7e-11 43.7 0.4 8.7e-05 23.0 0.2 4.5 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO26121.1 - 9.3e-11 41.8 0.7 0.039 14.3 0.0 5.1 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO26121.1 - 6.6e-09 35.3 1.1 0.046 14.3 0.0 6.0 3 1 1 4 4 4 1 Ankyrin repeat EF-hand_7 PF13499.6 KOO26121.1 - 1.2e-07 32.0 1.2 4.4e-07 30.2 1.1 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO26121.1 - 1.7e-06 27.5 0.2 0.025 14.5 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_11 PF08976.11 KOO26121.1 - 0.0028 18.5 0.0 0.0053 17.6 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 KOO26121.1 - 0.0042 16.9 4.5 0.02 14.8 0.8 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO26121.1 - 0.0099 15.3 3.1 0.37 10.4 0.0 3.2 3 0 0 3 3 3 1 EF hand Gamma_PGA_hydro PF05908.11 KOO26121.1 - 0.043 13.2 0.0 0.076 12.4 0.0 1.3 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase EF-hand_4 PF12763.7 KOO26121.1 - 0.13 12.2 0.3 0.46 10.5 0.2 1.8 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand LVIVD PF08309.11 KOO26123.1 - 3.1e-49 164.0 47.5 3.2e-11 42.4 2.8 6.3 5 1 1 6 6 6 6 LVIVD repeat Chitin_bind_4 PF00379.23 KOO26123.1 - 0.0019 18.7 14.4 22 5.6 0.0 6.3 6 0 0 6 6 6 2 Insect cuticle protein VHL PF01847.16 KOO26123.1 - 0.0066 16.4 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 VHL beta domain Beta_propel PF09826.9 KOO26123.1 - 0.016 14.0 0.2 22 3.7 0.0 3.6 3 1 0 4 4 4 0 Beta propeller domain Ufm1 PF03671.14 KOO26124.1 - 8.8e-41 137.9 0.1 1.1e-40 137.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Peptidase_S13 PF02113.15 KOO26124.1 - 0.11 11.2 0.0 0.13 11.0 0.0 1.0 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family TIG PF01833.24 KOO26125.1 - 0.0001 22.3 0.0 0.3 11.2 0.0 3.2 2 1 0 2 2 2 2 IPT/TIG domain TTL PF03133.15 KOO26126.1 - 1.3e-19 70.5 0.0 2.1e-18 66.5 0.0 2.2 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family LRR_6 PF13516.6 KOO26126.1 - 8.9e-13 47.2 12.0 0.0063 16.5 0.1 6.6 6 0 0 6 6 6 5 Leucine Rich repeat ATPgrasp_YheCD PF14398.6 KOO26126.1 - 3.4e-05 23.2 0.0 0.00012 21.4 0.0 1.9 2 0 0 2 2 2 1 YheC/D like ATP-grasp C2 PF00168.30 KOO26127.1 - 9.7e-18 64.4 0.0 1.4e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 C2 domain PAE PF03283.13 KOO26128.1 - 2.2e-10 40.2 0.0 5.5e-10 38.9 0.0 1.6 1 1 0 1 1 1 1 Pectinacetylesterase Cdh1_DBD_1 PF18196.1 KOO26129.1 - 0.055 13.8 1.8 0.06 13.7 1.8 1.2 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Phage_GP20 PF06810.11 KOO26129.1 - 0.11 12.3 4.1 0.13 12.1 4.1 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 YlqD PF11068.8 KOO26129.1 - 0.27 11.6 3.4 0.32 11.4 3.4 1.1 1 0 0 1 1 1 0 YlqD protein STELLO PF03385.17 KOO26130.1 - 1e-12 47.6 0.0 1.5e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 STELLO glycosyltransferases PKD_channel PF08016.12 KOO26131.1 - 1.6e-46 158.8 6.3 1.3e-37 129.5 5.3 2.2 1 1 1 2 2 2 2 Polycystin cation channel Tim44 PF04280.15 KOO26131.1 - 3.2e-15 56.5 0.0 6e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Tim44-like domain Ion_trans PF00520.31 KOO26131.1 - 1.1e-10 41.2 7.9 2e-10 40.4 7.9 1.4 1 0 0 1 1 1 1 Ion transport protein TFIIIC_delta PF12657.7 KOO26131.1 - 0.17 11.8 0.0 0.5 10.3 0.0 1.7 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term BPL_N PF09825.9 KOO26133.1 - 6.8e-07 28.7 2.2 0.00029 20.1 1.4 2.2 2 0 0 2 2 2 2 Biotin-protein ligase, N terminal DJ-1_PfpI PF01965.24 KOO26133.1 - 5.8e-05 23.0 0.2 9.6e-05 22.2 0.2 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family ThuA PF06283.11 KOO26133.1 - 0.093 12.9 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Trehalose utilisation Cpn60_TCP1 PF00118.24 KOO26134.1 - 2.4e-153 511.3 2.5 2.8e-153 511.1 2.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family XPG_I PF00867.18 KOO26135.1 - 6.3e-25 87.4 0.1 1.5e-24 86.1 0.1 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 KOO26135.1 - 1.6e-23 83.1 0.0 3e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain UPF0029 PF01205.19 KOO26135.1 - 2.3e-20 72.9 0.0 8.5e-20 71.1 0.0 2.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 DUF3915 PF13054.6 KOO26135.1 - 0.44 10.5 4.1 1.5 8.8 4.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Glyco_transf_8 PF01501.20 KOO26136.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 8 DEAD PF00270.29 KOO26137.1 - 3e-46 157.4 0.0 1.1e-45 155.5 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO26137.1 - 3.5e-31 107.8 0.0 1.6e-29 102.5 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO26137.1 - 1.2e-05 25.4 0.0 3.4e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOO26137.1 - 0.0085 15.3 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Penicillinase_R PF03965.16 KOO26137.1 - 0.013 15.9 0.0 0.033 14.5 0.0 1.7 1 0 0 1 1 1 0 Penicillinase repressor YopE_N PF09020.10 KOO26137.1 - 0.027 14.7 0.0 11 6.2 0.0 2.5 2 0 0 2 2 2 0 YopE, N terminal Herpes_capsid PF06112.11 KOO26138.1 - 2.1 8.4 12.4 4.4 7.3 12.4 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Toxin-deaminase PF14424.6 KOO26139.1 - 1.8e-05 24.9 0.0 3.3e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 The BURPS668_1122 family of deaminases FATC PF02260.20 KOO26141.1 - 3.9e-10 39.4 0.1 7.6e-10 38.4 0.1 1.5 1 0 0 1 1 1 1 FATC domain PI3_PI4_kinase PF00454.27 KOO26141.1 - 0.00028 20.8 0.0 0.00055 19.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase ASL_C PF08328.11 KOO26142.1 - 1.6e-49 166.7 0.0 3e-49 165.9 0.0 1.4 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminal Lyase_1 PF00206.20 KOO26142.1 - 9.8e-30 104.0 0.0 5.6e-20 72.0 0.0 2.2 2 0 0 2 2 2 2 Lyase Usp PF00582.26 KOO26142.1 - 0.052 14.1 0.1 0.12 12.9 0.1 1.6 1 0 0 1 1 1 0 Universal stress protein family zf-B_box PF00643.24 KOO26143.1 - 2.6e-09 37.1 6.8 2.6e-09 37.1 6.8 3.5 3 2 0 3 3 3 1 B-box zinc finger zf-RING_UBOX PF13445.6 KOO26143.1 - 1.5e-08 34.5 4.8 1.5e-08 34.5 4.8 3.0 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOO26143.1 - 2e-07 30.7 6.1 2e-07 30.7 6.1 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOO26143.1 - 2.3e-05 24.4 4.3 2.3e-05 24.4 4.3 3.0 3 1 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KOO26143.1 - 0.00019 21.3 13.2 0.00019 21.3 13.2 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO26143.1 - 0.0028 17.6 15.5 0.0028 17.6 15.5 3.0 2 2 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 KOO26143.1 - 0.0045 16.8 3.0 0.0045 16.8 3.0 2.2 3 0 0 3 3 3 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 KOO26143.1 - 0.012 15.9 18.4 0.012 15.9 18.4 3.1 2 1 0 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.6 KOO26143.1 - 0.035 13.9 1.8 0.035 13.9 1.8 4.0 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 KOO26143.1 - 0.39 10.6 9.0 1.5 8.7 9.0 2.0 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Glyco_hydro_127 PF07944.12 KOO26144.1 - 4.6e-93 312.5 0.0 5.8e-93 312.1 0.0 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Peptidase_M17_N PF02789.17 KOO26144.1 - 0.00016 21.6 0.1 0.22 11.4 0.0 2.5 2 0 0 2 2 2 2 Cytosol aminopeptidase family, N-terminal domain TPT PF03151.16 KOO26145.1 - 2.4e-53 181.4 9.1 2.9e-53 181.1 9.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO26145.1 - 9.2e-10 38.8 20.7 7.2e-08 32.7 4.5 3.6 3 1 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 KOO26145.1 - 9e-05 21.8 5.7 0.00022 20.6 5.6 1.8 1 1 0 1 1 1 1 UAA transporter family Borrelia_P83 PF05262.11 KOO26146.1 - 3.3 6.1 19.4 5 5.5 19.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein AAA_23 PF13476.6 KOO26146.1 - 9.8 6.6 9.8 21 5.5 9.8 1.6 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 KOO26147.1 - 2.1e-08 34.7 0.6 0.00047 20.9 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO26147.1 - 0.023 15.0 0.0 6.4 7.2 0.0 3.2 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOO26147.1 - 0.094 11.3 0.1 0.22 10.1 0.0 1.4 1 1 0 1 1 1 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 KOO26148.1 - 0.023 13.5 3.8 0.34 9.6 0.1 3.1 2 1 1 3 3 3 0 Nup133 N terminal like Ysc84 PF04366.12 KOO26149.1 - 3.9e-23 81.6 0.1 1.5e-22 79.7 0.1 2.1 1 0 0 1 1 1 1 Las17-binding protein actin regulator FH2 PF02181.23 KOO26151.1 - 1.5e-38 132.9 0.0 2.4e-34 119.1 0.0 2.1 2 0 0 2 2 2 2 Formin Homology 2 Domain Spidroin_MaSp PF11260.8 KOO26151.1 - 0.14 12.5 3.4 1.1 9.6 0.2 3.0 3 0 0 3 3 3 0 Major ampullate spidroin 1 and 2 Strabismus PF06638.11 KOO26152.1 - 0.025 13.2 0.2 0.035 12.8 0.2 1.2 1 0 0 1 1 1 0 Strabismus protein Pex24p PF06398.11 KOO26152.1 - 0.096 11.6 0.1 0.096 11.6 0.1 1.9 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin Reticulon PF02453.17 KOO26152.1 - 0.18 11.7 6.9 0.3 11.0 2.3 2.5 3 0 0 3 3 3 0 Reticulon Jiraiya PF15038.6 KOO26152.1 - 1 8.8 15.3 2.2 7.7 15.2 1.6 1 1 0 1 1 1 0 Jiraiya Orai-1 PF07856.12 KOO26152.1 - 1.3 8.7 11.1 7 6.3 5.1 2.7 3 0 0 3 3 3 0 Mediator of CRAC channel activity Phage_holin_3_6 PF07332.11 KOO26152.1 - 2.6 8.1 11.7 0.27 11.3 6.7 1.8 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III TPR_12 PF13424.6 KOO26153.1 - 8.1e-10 38.9 4.6 1.5e-09 38.0 1.6 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO26153.1 - 1.3e-09 37.4 2.1 0.00061 19.6 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26153.1 - 6.1e-08 32.3 0.7 1.2e-05 25.1 0.4 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26153.1 - 1.3e-06 28.0 3.4 0.0012 18.6 0.6 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO26153.1 - 1.4e-06 27.9 5.6 0.018 15.1 1.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO26153.1 - 3.7e-06 26.6 2.4 0.022 14.6 0.4 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF2225 PF09986.9 KOO26153.1 - 0.00071 19.4 0.9 0.00071 19.4 0.9 1.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_MalT PF17874.1 KOO26153.1 - 0.0023 17.3 0.6 0.0023 17.3 0.6 1.8 2 0 0 2 2 2 1 MalT-like TPR region TPR_19 PF14559.6 KOO26153.1 - 0.0051 17.3 2.5 0.59 10.7 0.1 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat DUF627 PF04781.12 KOO26153.1 - 0.023 14.7 0.6 0.057 13.4 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF627) TPR_14 PF13428.6 KOO26153.1 - 0.029 15.2 9.7 8.1 7.6 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26153.1 - 0.05 14.3 3.9 0.28 11.9 0.1 3.9 5 0 0 5 5 4 0 Tetratricopeptide repeat PI3K_P85_iSH2 PF16454.5 KOO26153.1 - 0.054 13.1 0.2 0.054 13.1 0.2 1.6 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain MIT PF04212.18 KOO26153.1 - 9 6.5 8.5 3 8.0 1.4 3.0 2 2 1 3 3 3 0 MIT (microtubule interacting and transport) domain IreB PF06135.12 KOO26154.1 - 0.18 12.0 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 IreB regulatory phosphoprotein Cofilin_ADF PF00241.20 KOO26155.1 - 6.3e-11 42.1 0.2 1.2e-10 41.3 0.2 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Pepsin-I3 PF06394.13 KOO26155.1 - 1.7 8.9 4.7 0.52 10.5 1.2 2.0 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain Acetyltransf_1 PF00583.25 KOO26157.1 - 9.6e-14 51.6 0.0 1.3e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOO26157.1 - 5.4e-10 39.3 0.0 7.2e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOO26157.1 - 3.2e-09 37.1 0.1 5.5e-09 36.3 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO26157.1 - 0.002 18.0 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 KOO26157.1 - 0.0074 16.4 0.0 0.0099 16.0 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOO26157.1 - 0.008 16.3 0.0 0.017 15.2 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 KOO26157.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SAM35 PF10806.8 KOO26157.1 - 0.15 12.3 0.0 0.23 11.7 0.0 1.2 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex Metallophos PF00149.28 KOO26158.1 - 2.6e-10 41.1 0.0 6.7e-10 39.8 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Myb_DNA-binding PF00249.31 KOO26159.1 - 5.4e-16 58.5 6.7 6.1e-12 45.5 0.1 2.7 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO26159.1 - 1.7e-11 44.2 0.8 3e-08 33.8 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.11 KOO26159.1 - 0.00071 19.7 0.0 1.9 8.7 0.0 2.5 2 0 0 2 2 2 2 Rap1 Myb domain SLIDE PF09111.10 KOO26159.1 - 0.00078 19.5 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 2 SLIDE DUF5401 PF17380.2 KOO26160.1 - 0.13 10.3 30.6 0.15 10.1 30.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) US30 PF17624.2 KOO26160.1 - 2.4 7.1 4.7 2.9 6.8 4.7 1.3 1 0 0 1 1 1 0 Family of unknown function PhyH PF05721.13 KOO26161.1 - 3.1e-08 34.1 0.0 9.1e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Dimer_Tnp_hAT PF05699.14 KOO26163.1 - 5.5e-05 22.9 0.1 8.3e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region ArfGap PF01412.18 KOO26164.1 - 6.7e-33 113.2 0.1 1.1e-32 112.6 0.1 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 KOO26164.1 - 1.5e-08 35.1 0.0 3e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KOO26164.1 - 0.0077 16.6 0.6 0.082 13.3 0.3 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain PH_17 PF18012.1 KOO26164.1 - 0.01 15.5 0.0 0.025 14.3 0.0 1.6 1 0 0 1 1 1 0 PH domain zf-C3HC4_3 PF13920.6 KOO26164.1 - 0.083 12.8 0.2 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 KOO26164.1 - 0.21 11.7 1.0 0.85 9.8 0.5 2.2 2 1 0 2 2 2 0 B-box zinc finger AAA_34 PF13872.6 KOO26165.1 - 5.4e-89 298.1 0.0 6.2e-89 297.9 0.0 1.0 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DUF4866 PF16160.5 KOO26165.1 - 0.017 14.4 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4866) Cys_rich_VLP PF14194.6 KOO26165.1 - 0.028 14.5 0.3 0.078 13.1 0.0 1.8 2 0 0 2 2 2 0 Cysteine-rich VLP ResIII PF04851.15 KOO26165.1 - 0.1 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Chloroa_b-bind PF00504.21 KOO26166.1 - 5.6e-25 88.8 0.1 8.6e-25 88.1 0.1 1.3 1 1 0 1 1 1 1 Chlorophyll A-B binding protein Tic22 PF04278.12 KOO26168.1 - 2.1e-13 50.2 0.0 2.8e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Tic22-like family Gp138_N PF18352.1 KOO26168.1 - 0.099 12.7 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Phage protein Gp138 N-terminal domain DUF3248 PF11609.8 KOO26169.1 - 0.078 12.9 0.1 0.23 11.4 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3248) LRR_6 PF13516.6 KOO26170.1 - 9.2e-17 59.6 5.8 0.037 14.1 0.0 7.3 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.7 KOO26170.1 - 5e-08 33.1 0.1 0.012 16.0 0.0 4.6 3 1 2 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO26170.1 - 0.058 13.2 6.7 49 3.8 0.2 5.7 4 2 0 4 4 4 0 Leucine rich repeat HCO3_cotransp PF00955.21 KOO26171.1 - 3.9e-49 167.8 0.2 5.4e-49 167.4 0.2 1.1 1 0 0 1 1 1 1 HCO3- transporter family DUF2935 PF11155.8 KOO26172.1 - 0.11 12.8 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Troponin PF00992.20 KOO26172.1 - 0.27 11.6 4.0 0.089 13.1 1.0 1.8 2 0 0 2 2 2 0 Troponin ALG3 PF05208.13 KOO26173.1 - 1.7e-118 396.1 0.2 2.2e-118 395.8 0.2 1.0 1 0 0 1 1 1 1 ALG3 protein Patatin PF01734.22 KOO26174.1 - 1.3e-07 32.0 1.7 0.0025 18.0 0.5 2.3 1 1 1 2 2 2 2 Patatin-like phospholipase Thioredoxin PF00085.20 KOO26176.1 - 0.00055 19.9 0.0 0.00095 19.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Helicase_C_4 PF13871.6 KOO26177.1 - 3.5e-96 322.0 1.6 1.3e-81 274.2 1.6 2.2 1 1 1 2 2 2 2 C-terminal domain on Strawberry notch homologue Helicase_C PF00271.31 KOO26177.1 - 0.012 16.0 0.0 0.026 14.9 0.0 1.6 1 0 0 1 1 1 0 Helicase conserved C-terminal domain SelR PF01641.18 KOO26178.1 - 4.8e-26 91.2 2.8 5.5e-26 91.0 2.8 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 KOO26178.1 - 0.085 13.1 3.3 0.31 11.3 3.3 1.8 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Exotox-A_target PF09102.10 KOO26178.1 - 0.15 12.1 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Exotoxin A, targeting MFS_1 PF07690.16 KOO26179.1 - 0.0005 19.1 48.4 0.00075 18.5 10.6 3.1 2 2 1 3 3 3 2 Major Facilitator Superfamily Fungus-induced PF10917.8 KOO26179.1 - 3.8 7.9 5.6 1 9.8 1.6 2.2 2 0 0 2 2 2 0 Fungus-induced protein AAA_34 PF13872.6 KOO26182.1 - 0.00012 21.1 0.0 0.00018 20.5 0.0 1.2 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Josephin PF02099.17 KOO26183.1 - 1.3e-41 142.4 0.1 1.9e-41 141.9 0.1 1.2 1 0 0 1 1 1 1 Josephin UBX PF00789.20 KOO26183.1 - 1.1e-08 35.1 0.0 2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 UBX domain UIM PF02809.20 KOO26183.1 - 0.023 14.6 1.7 0.055 13.4 1.7 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif ubiquitin PF00240.23 KOO26183.1 - 0.09 12.5 0.0 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 Ubiquitin family Melibiase_2 PF16499.5 KOO26184.1 - 1.4e-22 80.3 1.0 1.8e-22 79.9 1.0 1.1 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 KOO26184.1 - 1.6e-11 44.1 0.0 3.1e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain DEAD PF00270.29 KOO26185.1 - 6e-13 48.9 0.2 1.7e-10 41.0 0.1 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO26185.1 - 8.3e-13 48.7 0.0 3e-12 46.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 KOO26185.1 - 5e-07 30.1 0.1 1.1e-06 29.0 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO26185.1 - 2.8e-06 27.2 0.1 4.1e-05 23.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 KOO26185.1 - 2.7e-05 24.2 0.0 8.2e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOO26185.1 - 3.5e-05 24.1 0.3 0.00013 22.2 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 KOO26185.1 - 0.00011 21.8 0.0 0.00022 20.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KOO26185.1 - 0.0033 17.5 0.0 0.015 15.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 KOO26185.1 - 0.0091 15.9 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 KOO26185.1 - 0.012 16.1 0.0 0.037 14.4 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain AIRC PF00731.20 KOO26185.1 - 0.015 14.9 0.2 0.037 13.6 0.2 1.6 1 0 0 1 1 1 0 AIR carboxylase RsgA_GTPase PF03193.16 KOO26185.1 - 0.017 15.1 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 KOO26185.1 - 0.034 14.7 0.0 0.084 13.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter T2SSE PF00437.20 KOO26185.1 - 0.035 13.1 0.0 0.061 12.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 KOO26185.1 - 0.036 13.5 0.0 0.068 12.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein DAP3 PF10236.9 KOO26185.1 - 0.047 12.9 0.0 0.073 12.2 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 TrwB_AAD_bind PF10412.9 KOO26185.1 - 0.048 12.6 0.0 0.096 11.6 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 KOO26185.1 - 0.051 12.9 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_29 PF13555.6 KOO26185.1 - 0.07 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 KOO26185.1 - 0.077 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 KOO26185.1 - 0.087 13.3 0.1 0.15 12.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 KOO26185.1 - 0.12 11.8 0.1 0.19 11.2 0.1 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_7 PF12775.7 KOO26185.1 - 0.21 11.1 0.0 0.34 10.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region WD40 PF00400.32 KOO26186.1 - 5.3e-42 141.0 12.3 2.7e-09 37.5 0.2 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO26186.1 - 2.4e-14 53.0 1.0 0.02 13.9 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO26186.1 - 1.9e-13 50.5 0.9 0.0061 16.8 0.0 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO26186.1 - 1.1e-10 41.1 0.2 0.95 9.5 0.0 4.4 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO26186.1 - 3.6e-06 25.6 0.0 0.055 11.8 0.0 2.9 1 1 2 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KOO26186.1 - 8e-06 25.9 0.0 0.0018 18.2 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 KOO26186.1 - 1.7e-05 24.8 0.1 2.9 8.0 0.0 3.9 1 1 3 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 KOO26186.1 - 7.1e-05 22.3 1.8 2.2 7.6 0.0 3.6 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DCX PF03607.17 KOO26186.1 - 0.00028 20.9 0.0 1.7 8.8 0.0 3.9 4 0 0 4 4 4 1 Doublecortin WD40_3 PF15911.5 KOO26186.1 - 0.00064 19.7 0.9 4.6 7.3 0.0 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat WD40_like PF17005.5 KOO26186.1 - 0.00071 19.0 0.0 0.75 9.1 0.0 3.0 1 1 1 3 3 3 2 WD40-like domain rOmpB PF12334.8 KOO26186.1 - 0.0048 16.4 1.8 11 5.4 0.0 3.8 1 1 2 4 4 4 0 Rickettsia outer membrane protein B Plk4_PB1 PF18190.1 KOO26186.1 - 0.011 15.8 0.2 33 4.7 0.0 3.5 1 1 3 4 4 4 0 Polo-like Kinase 4 Polo Box 1 Dfp1_Him1_M PF08630.10 KOO26186.1 - 0.019 15.2 3.1 16 5.7 0.0 3.4 4 0 0 4 4 4 0 Dfp1/Him1, central region DUF1513 PF07433.11 KOO26186.1 - 0.019 14.1 0.0 0.27 10.3 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1513) UN_NPL4 PF11543.8 KOO26186.1 - 0.034 14.6 1.3 50 4.5 0.0 4.1 3 1 0 4 4 4 0 Nuclear pore localisation protein NPL4 Proteasome_A_N PF10584.9 KOO26186.1 - 0.042 13.5 6.7 18 5.1 0.1 4.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Gp_dh_C PF02800.20 KOO26187.1 - 3.6e-68 228.1 0.0 5.5e-68 227.5 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KOO26187.1 - 4.7e-32 110.3 0.0 1.2e-31 109.0 0.0 1.7 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 KOO26187.1 - 0.048 13.6 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase zf-C2H2_11 PF16622.5 KOO26188.1 - 0.55 10.0 0.1 0.55 10.0 0.1 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type NAGLU PF05089.12 KOO26189.1 - 6.4e-81 271.9 2.0 1.2e-80 270.9 2.0 1.4 1 1 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 KOO26189.1 - 9.4e-44 149.9 0.1 1.4e-43 149.4 0.1 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 KOO26189.1 - 4.9e-14 51.9 0.0 1.6e-13 50.2 0.0 1.9 2 0 0 2 2 2 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Glyco_transf_29 PF00777.18 KOO26190.1 - 8.8e-25 87.6 0.0 1.7e-22 80.1 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) LSDAT_euk PF18139.1 KOO26191.1 - 1.4e-37 129.5 0.0 7.8e-22 77.9 0.0 2.1 2 0 0 2 2 2 2 SLOG in TRPM LSDAT_prok PF18171.1 KOO26191.1 - 2.1e-19 69.5 0.0 7.4e-09 35.1 0.0 2.4 2 0 0 2 2 2 2 SLOG in TRPM, prokaryote FancD2 PF14631.6 KOO26192.1 - 5.1e-126 421.9 0.0 2.3e-80 270.6 0.0 3.1 3 0 0 3 3 3 3 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.6 KOO26192.1 - 0.00063 20.1 0.1 0.0082 16.5 0.0 3.1 3 0 0 3 3 3 1 FANCI solenoid 2 Ion_trans_2 PF07885.16 KOO26194.1 - 1.1e-14 54.2 1.6 2.4e-14 53.0 1.6 1.5 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 KOO26194.1 - 0.034 13.4 0.9 0.05 12.8 0.9 1.1 1 0 0 1 1 1 0 Ion transport protein EF-hand_5 PF13202.6 KOO26194.1 - 0.19 11.3 0.2 0.5 10.0 0.2 1.8 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 KOO26194.1 - 0.19 11.7 0.5 0.85 9.7 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain TruB_C PF09142.11 KOO26194.1 - 0.21 11.4 3.6 8.4 6.3 0.1 3.0 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal EF-hand_6 PF13405.6 KOO26196.1 - 7.6e-31 103.4 18.4 2.1e-05 24.1 0.2 7.6 9 0 0 9 9 9 6 EF-hand domain EF-hand_7 PF13499.6 KOO26196.1 - 2.1e-27 95.4 10.2 5.9e-10 39.5 1.2 4.7 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_1 PF00036.32 KOO26196.1 - 1.4e-25 86.9 24.1 0.00017 20.9 0.1 7.4 8 0 0 8 8 8 6 EF hand EF-hand_8 PF13833.6 KOO26196.1 - 8e-20 70.4 16.3 4.2e-07 29.7 0.0 6.2 2 2 4 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO26196.1 - 3e-18 64.4 20.5 0.00076 18.9 0.1 6.9 7 0 0 7 7 7 5 EF hand SPARC_Ca_bdg PF10591.9 KOO26196.1 - 0.00042 20.6 4.8 0.9 9.9 0.0 4.2 4 1 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO26196.1 - 0.033 15.1 0.0 35 5.3 0.0 3.1 2 1 1 3 3 3 0 EF-hand domain DUF1965 PF09248.10 KOO26196.1 - 0.06 13.1 0.0 5.2 6.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1965) Caleosin PF05042.13 KOO26196.1 - 0.094 12.6 0.5 7.9 6.4 0.1 3.1 2 1 1 3 3 3 0 Caleosin related protein EF-hand_4 PF12763.7 KOO26196.1 - 3 7.8 8.2 1.8 8.5 0.2 3.8 3 2 3 6 6 6 0 Cytoskeletal-regulatory complex EF hand AI-2E_transport PF01594.16 KOO26197.1 - 9.6e-38 130.1 33.3 3.5e-34 118.4 22.7 2.9 2 1 0 2 2 2 2 AI-2E family transporter RPE65 PF03055.15 KOO26199.1 - 9e-21 74.6 0.0 1.4e-15 57.5 0.0 2.0 1 1 1 2 2 2 2 Retinal pigment epithelial membrane protein Sulfotransfer_2 PF03567.14 KOO26201.1 - 2.1e-06 27.9 0.4 2.7e-06 27.5 0.4 1.2 1 0 0 1 1 1 1 Sulfotransferase family RNA_pol_Rpb1_1 PF04997.12 KOO26202.1 - 5.4e-62 209.9 1.3 8e-55 186.4 0.0 3.6 1 1 2 3 3 3 3 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 KOO26202.1 - 4.4e-54 183.2 0.6 2.6e-53 180.6 0.0 2.4 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_5 PF04998.17 KOO26202.1 - 4e-14 52.7 0.0 6.4e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_3 PF04983.18 KOO26202.1 - 1.5e-07 31.5 0.2 2.5e-05 24.3 0.0 3.2 1 1 2 3 3 3 1 RNA polymerase Rpb1, domain 3 Hairpins PF04877.12 KOO26202.1 - 0.042 13.5 0.4 0.67 9.5 0.1 2.4 2 0 0 2 2 2 0 HrpZ DUF4041 PF13250.6 KOO26202.1 - 0.81 9.6 7.4 1.6 8.7 0.1 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4041) MRP-S31 PF15433.6 KOO26203.1 - 2.4 7.7 4.3 3.7 7.1 4.3 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 EF-hand_8 PF13833.6 KOO26204.1 - 1.1e-15 57.2 0.2 1.8e-12 46.9 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO26204.1 - 1.1e-14 52.7 0.8 3.4e-06 26.2 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO26204.1 - 5.9e-14 52.3 0.1 1.2e-13 51.3 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO26204.1 - 9.8e-14 50.1 0.8 6.3e-06 25.4 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO26204.1 - 2.8e-12 45.5 0.8 5.4e-06 25.9 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain FKBP_C PF00254.28 KOO26204.1 - 7.3e-07 29.4 0.0 1.6e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase SPARC_Ca_bdg PF10591.9 KOO26204.1 - 0.067 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Arm PF00514.23 KOO26205.1 - 1.8e-35 119.9 16.1 9.1e-06 25.5 0.2 7.6 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat Aa_trans PF01490.18 KOO26205.1 - 5.2e-34 117.7 22.2 9.2e-20 70.7 0.3 2.2 1 1 0 2 2 2 2 Transmembrane amino acid transporter protein ART PF01129.18 KOO26205.1 - 0.00011 21.6 0.0 0.00018 20.8 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Atx10homo_assoc PF09759.9 KOO26205.1 - 0.034 14.2 0.1 0.5 10.4 0.0 2.7 3 1 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 KOO26205.1 - 0.05 14.1 15.2 0.46 11.0 0.5 4.7 3 1 1 4 4 4 0 HEAT-like repeat Arm_2 PF04826.13 KOO26205.1 - 0.07 12.6 0.1 41 3.5 0.0 3.1 1 1 2 4 4 4 0 Armadillo-like P_C10 PF14974.6 KOO26207.1 - 2.1e-10 40.6 0.1 2.9e-10 40.2 0.1 1.1 1 0 0 1 1 1 1 Protein C10 TPR_1 PF00515.28 KOO26208.1 - 0.015 15.1 2.3 0.046 13.6 0.3 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO26208.1 - 0.075 13.3 0.2 0.075 13.3 0.2 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 AAA PF00004.29 KOO26209.1 - 2.6e-27 95.8 0.0 1.7e-11 44.7 0.0 3.6 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_lid_6 PF17866.1 KOO26209.1 - 1.1e-21 76.7 0.8 1.3e-10 41.3 0.1 2.7 2 0 0 2 2 2 2 AAA lid domain TniB PF05621.11 KOO26209.1 - 1.6e-10 40.8 0.0 0.00081 18.9 0.0 3.9 4 0 0 4 4 4 2 Bacterial TniB protein AAA_22 PF13401.6 KOO26209.1 - 3.9e-08 33.7 3.2 0.34 11.2 0.2 4.8 4 1 0 4 4 4 3 AAA domain RuvB_N PF05496.12 KOO26209.1 - 1.3e-07 31.5 0.0 0.27 11.0 0.0 3.7 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KOO26209.1 - 6.7e-05 23.4 0.7 0.079 13.5 0.1 3.1 3 0 0 3 3 2 1 AAA domain Sigma54_activ_2 PF14532.6 KOO26209.1 - 7.1e-05 23.0 0.0 0.014 15.5 0.0 3.4 3 1 0 3 3 3 1 Sigma-54 interaction domain AAA_5 PF07728.14 KOO26209.1 - 8.6e-05 22.6 0.1 0.21 11.6 0.0 3.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOO26209.1 - 9.6e-05 21.9 1.4 0.54 9.6 0.1 3.7 3 1 1 4 4 4 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KOO26209.1 - 0.00011 22.6 0.0 0.17 12.3 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 KOO26209.1 - 0.00031 20.9 1.4 0.93 9.7 0.1 3.1 3 0 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 KOO26209.1 - 0.00041 20.1 1.3 1.2 8.8 0.0 4.1 6 0 0 6 6 4 1 Sigma-54 interaction domain AAA_16 PF13191.6 KOO26209.1 - 0.0021 18.5 0.4 0.55 10.6 0.0 3.1 3 0 0 3 3 2 1 AAA ATPase domain Thioredoxin PF00085.20 KOO26209.1 - 0.0042 17.0 0.0 0.0094 15.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin AAA_24 PF13479.6 KOO26209.1 - 0.0063 16.3 0.2 0.18 11.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KOO26209.1 - 0.014 15.2 0.2 1.1 9.0 0.1 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein Zot PF05707.12 KOO26209.1 - 0.017 14.8 0.0 9.7 5.8 0.0 3.7 3 0 0 3 3 3 0 Zonular occludens toxin (Zot) NTPase_1 PF03266.15 KOO26209.1 - 0.045 13.7 0.2 9 6.2 0.1 2.8 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 KOO26209.1 - 0.053 13.1 1.8 21 4.6 0.1 3.7 3 1 0 3 3 3 0 AAA domain NACHT PF05729.12 KOO26209.1 - 0.062 13.2 0.8 12 5.8 0.0 3.1 4 0 0 4 4 3 0 NACHT domain AAA_3 PF07726.11 KOO26209.1 - 0.074 12.9 0.0 0.77 9.6 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 KOO26209.1 - 0.1 11.6 0.9 2.8 6.8 0.0 2.8 2 1 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_19 PF13245.6 KOO26209.1 - 0.12 12.7 0.2 7.7 6.8 0.0 3.5 3 0 0 3 3 3 0 AAA domain DAO_C PF16901.5 KOO26209.1 - 0.13 12.1 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase CbiA PF01656.23 KOO26209.1 - 0.14 12.2 0.2 3.5 7.7 0.1 2.5 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_2 PF07724.14 KOO26209.1 - 0.14 12.2 0.0 8.3 6.5 0.1 3.1 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) ABC_tran PF00005.27 KOO26209.1 - 0.15 12.5 0.3 3.9 8.0 0.0 2.8 2 0 0 2 2 2 0 ABC transporter KTI12 PF08433.10 KOO26209.1 - 0.17 11.3 0.0 10 5.5 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Seryl_tRNA_N PF02403.22 KOO26209.1 - 0.18 12.1 1.5 1.3e+02 2.8 0.0 4.3 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain SpdB PF05122.13 KOO26209.1 - 0.32 11.2 1.5 24 5.2 0.3 2.5 2 0 0 2 2 2 0 Mobile element transfer protein AAA_17 PF13207.6 KOO26209.1 - 3.4 8.1 5.4 3.7 8.0 0.2 3.1 3 0 0 3 3 2 0 AAA domain DUF1289 PF06945.13 KOO26210.1 - 0.12 12.2 0.2 0.58 10.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) MinC_C PF03775.16 KOO26211.1 - 0.08 12.9 2.1 0.15 12.1 2.1 1.4 1 0 0 1 1 1 0 Septum formation inhibitor MinC, C-terminal domain FapA PF03961.13 KOO26211.1 - 0.086 11.4 6.6 0.11 11.1 6.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A SQAPI PF16845.5 KOO26212.1 - 5.5e-07 29.8 0.1 1.5e-06 28.5 0.1 1.7 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cystatin PF00031.21 KOO26212.1 - 0.0014 18.8 0.2 0.0031 17.7 0.2 1.6 1 0 0 1 1 1 1 Cystatin domain SCAPER_N PF16501.5 KOO26213.1 - 0.0041 17.1 0.7 0.011 15.8 0.0 1.9 2 0 0 2 2 2 1 S phase cyclin A-associated protein in the endoplasmic reticulum BAR_2 PF10455.9 KOO26216.1 - 0.077 12.1 0.1 0.1 11.7 0.1 1.1 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Sirohm_synth_C PF14823.6 KOO26217.1 - 0.15 11.8 0.2 0.2 11.3 0.2 1.1 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal Filamin PF00630.19 KOO26218.1 - 2.7e-41 140.6 0.0 1.2e-14 55.0 0.0 5.8 5 1 0 5 5 5 4 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO26218.1 - 1.3e-08 35.0 1.0 0.18 12.1 0.1 5.9 5 1 1 6 6 6 3 Invasin, domain 3 Cadherin_5 PF17892.1 KOO26218.1 - 0.00011 22.1 0.5 0.23 11.5 0.0 3.6 4 1 0 4 4 4 2 Cadherin-like domain SH3_3 PF08239.11 KOO26218.1 - 0.00014 22.1 0.2 0.00041 20.6 0.0 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain CopC PF04234.12 KOO26218.1 - 0.0028 18.6 0.1 4.9 8.3 0.0 3.8 3 0 0 3 3 3 1 CopC domain Big_9 PF17963.1 KOO26218.1 - 0.89 10.3 11.9 5 7.9 0.6 4.4 4 1 0 4 4 4 0 Bacterial Ig domain WD40 PF00400.32 KOO26219.1 - 1.6e-14 54.0 9.2 0.00012 22.8 0.2 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO26219.1 - 8.6e-11 42.0 1.0 0.0004 20.6 0.0 5.2 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOO26219.1 - 0.0084 14.8 0.6 0.46 9.1 0.1 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 KOO26219.1 - 0.024 13.6 0.6 19 4.0 0.0 3.1 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 KOO26219.1 - 0.15 10.7 0.2 0.29 9.8 0.2 1.4 1 0 0 1 1 1 0 Nup133 N terminal like VID27 PF08553.10 KOO26220.1 - 5.8e-15 55.2 0.0 7.5e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain CBM_6 PF03422.15 KOO26220.1 - 0.011 16.0 0.1 0.26 11.6 0.0 2.5 2 0 0 2 2 2 0 Carbohydrate binding module (family 6) ubiquitin PF00240.23 KOO26221.1 - 0.002 17.8 0.0 4.2 7.2 0.0 3.6 4 0 0 4 4 4 2 Ubiquitin family Rad60-SLD PF11976.8 KOO26221.1 - 0.08 12.8 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Ion_trans PF00520.31 KOO26222.1 - 2.6e-23 82.5 3.2 4.9e-23 81.6 3.2 1.3 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO26222.1 - 1.3e-16 60.3 1.4 1.3e-16 60.3 1.4 2.4 2 0 0 2 2 2 1 Ion channel EF-hand_6 PF13405.6 KOO26222.1 - 9.5e-05 22.0 0.0 0.12 12.4 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO26222.1 - 0.00013 21.3 0.5 0.0012 18.3 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 KOO26222.1 - 0.00016 21.0 0.1 0.0082 15.6 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO26222.1 - 0.0017 18.8 0.1 0.018 15.5 0.1 2.2 1 1 0 1 1 1 1 EF-hand domain pair DZR PF12773.7 KOO26222.1 - 0.047 13.7 1.2 0.079 13.0 1.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 KOO26222.1 - 1.4 8.8 4.0 2.5 7.9 4.0 1.5 1 0 0 1 1 1 0 zinc-ribbon domain PKD_channel PF08016.12 KOO26223.1 - 1.3e-16 60.4 16.4 4e-15 55.4 17.0 2.6 2 1 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 KOO26223.1 - 1.8e-06 27.4 21.0 3.4e-06 26.5 21.0 1.5 1 1 0 1 1 1 1 Ion transport protein Tetraspanin PF00335.20 KOO26223.1 - 0.057 13.1 1.7 0.092 12.4 1.7 1.3 1 0 0 1 1 1 0 Tetraspanin family Dimer_Tnp_hAT PF05699.14 KOO26224.1 - 2.3e-05 24.1 0.1 2.5e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region LRR_6 PF13516.6 KOO26225.1 - 0.075 13.1 0.2 11 6.3 0.1 2.2 2 0 0 2 2 2 0 Leucine Rich repeat Ribosomal_L26 PF16906.5 KOO26226.1 - 1.2e-35 121.8 2.0 2e-35 121.1 2.0 1.4 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal PCMT PF01135.19 KOO26226.1 - 5.7e-28 98.1 0.0 8.1e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) KOW PF00467.29 KOO26226.1 - 5.8e-06 26.1 2.7 1e-05 25.3 0.7 2.2 2 0 0 2 2 2 1 KOW motif Ubie_methyltran PF01209.18 KOO26226.1 - 0.02 14.2 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF3246 PF11596.8 KOO26226.1 - 0.04 13.3 1.9 0.065 12.7 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Methyltransf_25 PF13649.6 KOO26226.1 - 0.047 14.4 0.0 0.098 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 KOO26226.1 - 0.16 11.0 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TPR_2 PF07719.17 KOO26227.1 - 4.2e-14 51.4 10.5 7.2e-05 22.6 0.5 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26227.1 - 3.2e-13 48.9 9.4 3.6e-05 23.4 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26227.1 - 4.9e-08 32.6 2.4 0.011 15.9 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat CS PF04969.16 KOO26227.1 - 9.5e-08 33.0 0.0 1.8e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 CS domain TPR_17 PF13431.6 KOO26227.1 - 2.9e-06 27.3 0.7 0.084 13.3 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26227.1 - 1.4e-05 25.5 13.5 0.00083 19.8 1.0 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO26227.1 - 3.8e-05 24.2 12.7 0.00073 20.1 1.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat CAP_C PF08603.11 KOO26227.1 - 0.00011 21.9 0.0 0.0002 21.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TPR_11 PF13414.6 KOO26227.1 - 0.00015 21.4 4.7 0.018 14.7 0.3 3.0 2 1 1 3 3 3 2 TPR repeat TPR_14 PF13428.6 KOO26227.1 - 0.0025 18.5 5.5 0.095 13.6 1.3 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO26227.1 - 0.0033 17.3 4.5 4 7.7 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26227.1 - 0.012 16.2 3.9 1.4 9.7 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO26227.1 - 0.015 15.6 10.7 0.38 11.1 3.4 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO26227.1 - 0.051 13.7 5.5 1.2 9.4 0.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TBCC PF07986.12 KOO26227.1 - 0.1 12.4 0.4 0.99 9.2 0.1 2.2 1 1 1 2 2 2 0 Tubulin binding cofactor C NAD_binding_10 PF13460.6 KOO26230.1 - 1.8e-21 76.8 0.0 2.8e-21 76.2 0.0 1.3 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOO26230.1 - 1.2e-05 24.9 0.0 2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO26230.1 - 0.0067 15.5 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 KOO26230.1 - 0.053 13.1 0.1 0.076 12.6 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family DapB_N PF01113.20 KOO26230.1 - 0.09 12.9 0.1 0.16 12.1 0.1 1.6 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Chloroa_b-bind PF00504.21 KOO26231.1 - 1.5e-35 123.1 0.0 1.8e-35 122.9 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Zip PF02535.22 KOO26232.1 - 9.3e-36 123.7 13.0 1.1e-35 123.5 13.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Glyco_hydro_9 PF00759.19 KOO26232.1 - 0.033 13.6 0.2 0.047 13.1 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 LRR_6 PF13516.6 KOO26234.1 - 1.9e-13 49.3 45.5 0.014 15.4 0.1 13.0 14 0 0 14 14 13 5 Leucine Rich repeat LRR_4 PF12799.7 KOO26234.1 - 2.2e-08 34.3 41.1 0.019 15.4 1.3 9.8 7 3 3 10 10 10 5 Leucine Rich repeats (2 copies) Roc PF08477.13 KOO26234.1 - 3.1e-08 33.9 0.0 6.9e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 KOO26234.1 - 0.0004 20.3 1.6 0.017 15.0 0.0 3.7 3 1 0 3 3 3 1 NACHT domain EF-hand_5 PF13202.6 KOO26234.1 - 0.0012 18.2 0.0 0.0039 16.6 0.0 1.9 1 0 0 1 1 1 1 EF hand LRR_8 PF13855.6 KOO26234.1 - 0.0013 18.5 38.5 0.0017 18.0 2.7 8.8 6 4 3 9 9 9 3 Leucine rich repeat AAA_22 PF13401.6 KOO26234.1 - 0.0015 18.8 0.1 1.2 9.4 0.0 3.5 3 0 0 3 3 3 1 AAA domain EF-hand_6 PF13405.6 KOO26234.1 - 0.013 15.4 0.2 0.081 12.9 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 KOO26234.1 - 0.014 14.9 0.0 0.063 12.9 0.0 2.2 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 KOO26234.1 - 0.019 14.8 0.0 0.098 12.5 0.0 2.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_7 PF13499.6 KOO26234.1 - 0.031 14.7 0.4 0.46 11.0 0.0 2.8 1 1 1 2 2 2 0 EF-hand domain pair PduV-EutP PF10662.9 KOO26234.1 - 0.051 13.3 0.0 0.18 11.5 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 KOO26234.1 - 0.053 13.8 0.1 0.25 11.7 0.1 2.2 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 KOO26234.1 - 0.15 11.6 1.3 0.28 10.7 0.0 2.1 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain LRR_9 PF14580.6 KOO26234.1 - 0.46 10.0 4.7 0.15 11.6 1.2 1.9 2 0 0 2 2 2 0 Leucine-rich repeat Ric8 PF10165.9 KOO26235.1 - 5.4e-11 42.2 0.0 1.4e-10 40.8 0.0 1.7 1 1 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Ribosomal_L27 PF01016.19 KOO26237.1 - 1.5e-28 98.6 0.1 2.2e-28 98.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal L27 protein TPR_11 PF13414.6 KOO26238.1 - 0.00072 19.2 0.2 0.0019 17.8 0.2 1.7 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.28 KOO26238.1 - 0.027 14.3 3.5 0.086 12.7 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26238.1 - 0.093 13.0 1.7 1.6 9.1 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO26238.1 - 0.12 13.2 0.2 0.12 13.2 0.2 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO26238.1 - 0.29 11.4 0.2 0.29 11.4 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ARS2 PF04959.13 KOO26239.1 - 9e-12 45.8 0.1 1.7e-11 44.9 0.1 1.3 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF3546 PF12066.8 KOO26239.1 - 0.013 15.6 0.0 0.028 14.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3546) C2 PF00168.30 KOO26242.1 - 7.4e-15 55.1 0.0 6.6e-05 23.1 0.0 3.9 5 0 0 5 5 5 3 C2 domain FerI PF08151.12 KOO26242.1 - 0.039 14.0 0.0 0.096 12.8 0.0 1.6 1 0 0 1 1 1 0 FerI (NUC094) domain SUZ-C PF12901.7 KOO26242.1 - 0.19 11.8 0.3 0.5 10.4 0.3 1.8 1 0 0 1 1 1 0 SUZ-C motif EF-hand_7 PF13499.6 KOO26243.1 - 1.2e-14 54.5 0.1 0.00057 20.3 0.0 5.6 2 1 3 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO26243.1 - 7.1e-13 47.4 4.7 0.0035 17.1 0.1 7.0 7 1 0 7 7 7 2 EF-hand domain EF-hand_1 PF00036.32 KOO26243.1 - 1.8e-12 45.8 5.5 0.00032 20.0 0.0 7.0 7 0 0 7 7 7 3 EF hand EF-hand_5 PF13202.6 KOO26243.1 - 9.8e-09 34.3 1.8 6.2e-05 22.3 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO26243.1 - 0.00023 21.0 6.0 2 8.3 0.0 5.8 6 1 0 6 6 6 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO26243.1 - 0.0012 18.7 0.1 0.033 14.1 0.0 3.0 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO26243.1 - 0.0036 17.1 0.0 8.7 6.3 0.0 3.7 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 KOO26243.1 - 0.0043 17.4 0.0 2.7 8.3 0.0 2.8 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region ADP_ribosyl_GH PF03747.14 KOO26244.1 - 9.4e-19 68.2 0.1 1.1e-18 68.0 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase PAS_4 PF08448.10 KOO26245.1 - 0.0017 18.6 0.0 0.55 10.5 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 KOO26245.1 - 0.011 16.0 0.0 2.2 8.6 0.0 3.0 2 2 0 2 2 2 0 PAS domain PAS PF00989.25 KOO26245.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 PAS fold Hydrolase_6 PF13344.6 KOO26246.1 - 7.1e-11 42.1 0.0 1.4e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO26246.1 - 9.6e-05 22.4 0.0 0.00022 21.2 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Trypsin_2 PF13365.6 KOO26247.1 - 6.2e-14 53.1 1.3 4.4e-13 50.4 0.0 3.0 3 0 0 3 3 3 1 Trypsin-like peptidase domain zf-RanBP PF00641.18 KOO26247.1 - 2.2e-08 33.2 10.0 0.00052 19.3 4.3 2.7 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others ZZ PF00569.17 KOO26247.1 - 0.19 11.6 0.9 0.59 10.0 0.9 1.8 1 0 0 1 1 1 0 Zinc finger, ZZ type AAA_12 PF13087.6 KOO26248.1 - 7.2e-36 123.7 0.0 1.5e-35 122.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO26248.1 - 1.8e-25 90.3 4.8 1.8e-24 86.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain zf-CCCH_4 PF18044.1 KOO26248.1 - 1e-07 31.5 1.3 2.3e-07 30.4 1.3 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 KOO26248.1 - 2.6e-07 30.4 2.7 5.2e-07 29.4 2.7 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOO26248.1 - 5.3e-07 29.5 4.9 1.2e-06 28.4 4.9 1.6 1 0 0 1 1 1 1 Zinc finger domain AAA_30 PF13604.6 KOO26248.1 - 2.1e-06 27.6 8.7 2.3e-05 24.2 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 KOO26248.1 - 0.0002 21.8 0.4 0.0002 21.8 0.4 3.7 4 1 0 4 4 2 1 AAA ATPase domain AAA_19 PF13245.6 KOO26248.1 - 0.00028 21.3 0.0 0.0044 17.4 0.0 2.6 1 1 0 1 1 1 1 AAA domain Torus PF16131.5 KOO26248.1 - 0.00079 20.1 0.5 0.00079 20.1 0.5 2.3 2 0 0 2 2 1 1 Torus domain AAA_5 PF07728.14 KOO26248.1 - 0.0031 17.5 0.0 0.044 13.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO26248.1 - 0.036 14.3 0.2 1.1 9.5 0.0 3.0 2 1 1 3 3 3 0 AAA domain RNA_helicase PF00910.22 KOO26248.1 - 0.068 13.6 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase MecA PF05389.12 KOO26248.1 - 0.07 12.8 0.3 0.14 11.8 0.3 1.4 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF2075 PF09848.9 KOO26248.1 - 0.12 11.5 0.0 0.12 11.5 0.0 3.1 5 0 0 5 5 4 0 Uncharacterized conserved protein (DUF2075) zf-CCCH_3 PF15663.5 KOO26248.1 - 0.18 12.1 0.8 0.55 10.5 0.8 1.8 1 0 0 1 1 1 0 Zinc-finger containing family AAA_25 PF13481.6 KOO26248.1 - 0.19 11.3 0.0 0.19 11.3 0.0 4.2 4 0 0 4 4 4 0 AAA domain zf-CCCH_2 PF14608.6 KOO26248.1 - 0.72 10.4 2.6 1.8 9.2 2.6 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Ferritin PF00210.24 KOO26249.1 - 0.2 11.6 0.0 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 Ferritin-like domain BRO1 PF03097.18 KOO26250.1 - 3.4e-81 273.0 2.3 1.9e-80 270.5 2.3 2.0 1 1 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KOO26250.1 - 1.1e-35 123.3 0.0 2.8e-35 122.0 0.0 1.7 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV SLATT_5 PF18160.1 KOO26250.1 - 0.071 12.4 1.7 0.14 11.5 1.7 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF1283 PF06932.11 KOO26250.1 - 0.17 12.1 0.1 0.48 10.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1283) Med4 PF10018.9 KOO26250.1 - 3.4 7.3 6.7 0.61 9.7 0.8 2.6 2 2 1 3 3 3 0 Vitamin-D-receptor interacting Mediator subunit 4 ZapB PF06005.12 KOO26250.1 - 6.3 7.3 6.5 39 4.8 0.0 3.4 4 0 0 4 4 4 0 Cell division protein ZapB DUF2749 PF10907.8 KOO26251.1 - 2.4 8.4 6.7 0.56 10.4 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2749) Mg-por_mtran_C PF07109.11 KOO26252.1 - 0.057 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium-protoporphyrin IX methyltransferase C-terminus SRP_SPB PF02978.19 KOO26253.1 - 0.00018 22.1 0.5 0.00051 20.6 0.4 1.9 1 1 0 1 1 1 1 Signal peptide binding domain DUF4618 PF15397.6 KOO26253.1 - 0.15 11.4 5.4 0.21 11.0 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Peptidase_S10 PF00450.22 KOO26254.1 - 2.4e-91 307.3 0.1 3.4e-91 306.7 0.1 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase TPR_10 PF13374.6 KOO26254.1 - 2.7e-28 97.0 14.9 2.2e-09 36.9 0.0 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOO26254.1 - 4.7e-27 94.1 10.3 6.3e-14 52.0 0.2 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO26254.1 - 1.6e-09 37.2 6.5 0.14 12.3 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO26254.1 - 4e-09 36.3 0.9 4e-09 36.3 0.9 2.3 2 0 0 2 2 2 1 MalT-like TPR region TPR_1 PF00515.28 KOO26254.1 - 4.2e-09 35.8 1.2 0.37 10.7 0.1 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO26254.1 - 0.00074 19.4 7.2 0.74 10.0 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26254.1 - 0.0016 18.5 0.9 30 5.2 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26254.1 - 0.0074 16.8 15.2 0.26 11.8 0.0 4.6 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO26254.1 - 0.013 16.2 16.7 1.4 10.0 0.1 6.2 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO26254.1 - 0.073 13.7 25.5 0.03 15.0 2.7 5.9 6 1 0 6 6 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO26254.1 - 0.25 11.1 2.9 3.9 7.2 0.0 3.1 3 0 0 3 3 2 0 TPR repeat FUSC PF04632.12 KOO26254.1 - 3.2 6.2 11.6 0.17 10.4 4.7 2.0 2 0 0 2 2 2 0 Fusaric acid resistance protein family TPR_4 PF07721.14 KOO26254.1 - 5 8.1 13.4 13 6.7 0.0 6.0 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26254.1 - 9.9 7.1 7.0 28 5.7 0.1 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat zf-C2H2 PF00096.26 KOO26256.1 - 3.5e-10 39.8 22.7 0.00081 19.7 0.3 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOO26256.1 - 5.4e-07 29.9 24.3 0.055 14.3 0.5 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOO26256.1 - 3.4e-06 27.2 9.2 0.0025 18.1 0.4 3.1 2 1 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOO26256.1 - 6.5e-06 26.3 7.9 0.026 14.9 0.3 3.7 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 KOO26256.1 - 3.7e-05 24.0 16.5 0.24 11.9 2.6 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 KOO26256.1 - 0.00087 19.2 0.1 0.00087 19.2 0.1 4.3 4 1 0 4 4 4 1 C2H2-type zinc finger zf-Di19 PF05605.12 KOO26256.1 - 0.0024 18.1 5.5 1.1 9.6 2.3 2.6 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.6 KOO26256.1 - 0.014 15.4 5.1 1.1 9.4 0.0 3.1 3 0 0 3 3 3 0 CpXC protein HypA PF01155.19 KOO26256.1 - 0.056 13.5 0.7 0.056 13.5 0.7 1.9 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_4 PF13717.6 KOO26256.1 - 0.062 13.2 3.8 1.3 9.1 0.0 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2H2_2 PF12756.7 KOO26256.1 - 0.091 13.1 13.1 0.61 10.5 0.0 3.8 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) Imm-NTF2-2 PF15631.6 KOO26256.1 - 0.18 12.1 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 NTF2 fold immunity protein Zn-ribbon_8 PF09723.10 KOO26256.1 - 0.31 11.2 5.4 1.3 9.2 1.2 3.1 2 1 0 2 2 2 0 Zinc ribbon domain DUF629 PF04780.12 KOO26256.1 - 0.97 7.9 3.5 11 4.4 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF629) zf_UBZ PF18439.1 KOO26256.1 - 2.7 7.6 6.4 9.7 5.9 0.1 3.4 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-LYAR PF08790.11 KOO26256.1 - 5.2 7.1 9.0 11 6.0 1.1 3.1 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger GPHR_N PF12537.8 KOO26257.1 - 0.11 12.6 4.1 7.3 6.8 0.3 2.5 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal LST1 PF05083.13 KOO26257.1 - 0.31 11.3 2.5 3.3 8.1 0.1 2.7 2 0 0 2 2 2 0 LST-1 protein ATP-synt_C PF00137.21 KOO26257.1 - 0.55 10.6 19.2 0.89 9.9 2.5 3.7 4 0 0 4 4 4 0 ATP synthase subunit C FAST_1 PF06743.15 KOO26258.1 - 7.3e-13 48.3 0.0 1.2 9.1 0.0 6.7 2 2 6 8 8 8 6 FAST kinase-like protein, subdomain 1 DUF1601 PF07671.11 KOO26258.1 - 0.00058 19.7 8.5 2.3 8.2 0.0 6.3 7 0 0 7 7 7 2 Protein of unknown function (DUF1601) FAD_binding_3 PF01494.19 KOO26258.1 - 0.059 12.6 0.0 0.17 11.1 0.0 1.7 1 0 0 1 1 1 0 FAD binding domain ING PF12998.7 KOO26260.1 - 8.9e-14 51.9 1.6 1.4e-13 51.3 1.6 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding DUF1325 PF07039.11 KOO26260.1 - 1.1e-08 35.2 0.1 7.9e-05 22.7 0.0 3.0 2 1 1 3 3 3 2 SGF29 tudor-like domain DNA_repr_REX1B PF14966.6 KOO26260.1 - 0.024 15.3 1.1 0.045 14.4 0.4 1.8 1 1 0 1 1 1 0 DNA repair REX1-B PIN_12 PF16289.5 KOO26260.1 - 0.089 13.3 2.0 0.13 12.7 0.8 1.7 1 1 1 2 2 2 0 PIN domain BLOC1_2 PF10046.9 KOO26260.1 - 0.34 11.2 2.7 21 5.5 0.1 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FemAB PF02388.16 KOO26260.1 - 0.49 9.2 3.9 0.55 9.1 1.7 1.8 1 1 1 2 2 2 0 FemAB family DAHP_synth_1 PF00793.20 KOO26262.1 - 1.3e-40 139.1 0.0 8.5e-22 77.3 0.0 2.5 2 1 0 2 2 2 2 DAHP synthetase I family Acatn PF13000.7 KOO26264.1 - 1.2e-62 212.2 10.8 4.6e-39 134.3 3.0 3.9 1 1 1 3 3 3 3 Acetyl-coenzyme A transporter 1 Pentapeptide_4 PF13599.6 KOO26265.1 - 0.0018 18.4 0.0 0.98 9.6 0.0 3.0 1 1 2 3 3 3 2 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.18 KOO26265.1 - 0.0032 17.4 7.7 4 7.3 0.1 5.6 2 2 2 5 5 5 2 Ribosomal protein L13e MerR-DNA-bind PF09278.11 KOO26265.1 - 0.0039 17.7 3.9 20 5.8 0.0 5.8 5 1 1 6 6 6 2 MerR, DNA binding N_methyl PF07963.12 KOO26265.1 - 0.039 13.5 3.3 7.8 6.2 0.0 3.9 4 0 0 4 4 4 0 Prokaryotic N-terminal methylation motif CorA PF01544.18 KOO26266.1 - 5.5e-07 29.2 4.0 2.1e-06 27.3 0.1 2.5 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF2721 PF11026.8 KOO26266.1 - 2.1e-05 24.4 0.5 5.8e-05 23.0 0.5 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2721) Tmemb_cc2 PF10267.9 KOO26266.1 - 0.052 12.7 0.1 0.089 11.9 0.1 1.4 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein CLZ PF16526.5 KOO26266.1 - 3.2 8.2 8.3 2.1 8.8 0.6 3.9 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SKA2 PF16740.5 KOO26266.1 - 7 6.5 10.4 0.13 12.0 0.6 2.8 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Methyltransf_11 PF08241.12 KOO26268.1 - 5.7e-07 30.1 0.0 1.7e-06 28.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO26268.1 - 7.5e-06 26.6 0.0 1.9e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO26268.1 - 3.6e-05 23.7 0.0 6.2e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO26268.1 - 3.8e-05 23.1 0.0 7.6e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 KOO26268.1 - 0.00022 21.9 0.0 0.00041 21.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO26268.1 - 0.00045 20.0 0.0 0.00078 19.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 KOO26268.1 - 0.001 18.6 0.0 0.0022 17.5 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 KOO26268.1 - 0.0055 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO26268.1 - 0.011 15.5 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Arm PF00514.23 KOO26269.1 - 7.8e-22 76.6 37.9 0.00026 20.9 0.1 8.8 8 1 0 8 8 8 6 Armadillo/beta-catenin-like repeat U-box PF04564.15 KOO26269.1 - 1e-17 64.1 0.0 2.1e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO26269.1 - 9.4e-05 22.2 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Atx10homo_assoc PF09759.9 KOO26269.1 - 0.00083 19.3 0.0 7 6.7 0.0 4.4 2 2 3 5 5 5 1 Spinocerebellar ataxia type 10 protein domain zf-NOSIP PF15906.5 KOO26269.1 - 0.042 14.0 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_UBOX PF13445.6 KOO26269.1 - 0.049 13.7 0.0 0.084 12.9 0.0 1.3 1 0 0 1 1 1 0 RING-type zinc-finger BAF1_ABF1 PF04684.13 KOO26269.1 - 1.2 8.1 8.0 1.9 7.4 8.0 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF737 PF05300.11 KOO26269.1 - 4.2 7.7 12.8 7.6 6.8 12.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF737) HTH_OrfB_IS605 PF12323.8 KOO26270.1 - 5.8e-05 22.5 14.2 0.063 12.8 0.1 5.0 5 0 0 5 5 5 3 Helix-turn-helix domain Fis1_TPR_C PF14853.6 KOO26270.1 - 0.0034 17.4 5.1 10 6.3 0.0 4.8 6 0 0 6 6 6 2 Fis1 C-terminal tetratricopeptide repeat GAF PF01590.26 KOO26270.1 - 0.1 13.2 4.6 14 6.3 4.6 2.6 1 1 0 1 1 1 0 GAF domain FSH1 PF03959.13 KOO26271.1 - 3.3e-13 49.8 0.1 2.2e-11 43.8 0.1 2.1 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Methyltransf_11 PF08241.12 KOO26272.1 - 8.3e-09 36.0 0.0 1.7e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO26272.1 - 1.5e-05 25.6 0.0 5.2e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DSBA PF01323.20 KOO26272.1 - 0.00013 21.8 0.0 0.0003 20.6 0.0 1.5 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Ubie_methyltran PF01209.18 KOO26272.1 - 0.0016 17.8 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KOO26272.1 - 0.0028 17.5 0.0 0.0056 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO26272.1 - 0.0047 16.7 0.0 0.0078 16.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.18 KOO26272.1 - 0.0059 16.3 0.0 0.0092 15.7 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Methyltransf_12 PF08242.12 KOO26272.1 - 0.0077 17.0 0.0 0.019 15.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 KOO26272.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW TPR_16 PF13432.6 KOO26273.1 - 3.2e-06 27.7 2.7 3.2e-06 27.7 2.7 5.7 5 2 1 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO26273.1 - 1.4e-05 24.9 14.3 0.0083 16.2 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat AAA_16 PF13191.6 KOO26273.1 - 0.001 19.5 0.2 0.001 19.5 0.2 2.3 2 0 0 2 2 2 1 AAA ATPase domain TPR_12 PF13424.6 KOO26273.1 - 0.0044 17.3 4.7 0.0044 17.3 4.7 3.8 3 2 1 4 4 4 1 Tetratricopeptide repeat Zeta_toxin PF06414.12 KOO26273.1 - 0.006 15.9 0.9 0.024 13.9 0.1 2.0 2 0 0 2 2 2 1 Zeta toxin TPR_1 PF00515.28 KOO26273.1 - 0.012 15.4 11.5 0.14 12.0 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA_22 PF13401.6 KOO26273.1 - 0.014 15.6 0.1 0.052 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain AIRS PF00586.24 KOO26273.1 - 0.021 15.5 3.3 0.81 10.4 0.3 2.9 2 1 1 3 3 3 0 AIR synthase related protein, N-terminal domain Ecm33 PF12454.8 KOO26273.1 - 0.03 14.4 0.0 0.28 11.4 0.0 2.7 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein Hpt PF01627.23 KOO26273.1 - 0.061 13.6 0.3 0.061 13.6 0.3 3.4 3 1 0 3 3 3 0 Hpt domain AAA_23 PF13476.6 KOO26273.1 - 0.07 13.6 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO26273.1 - 0.13 12.1 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_assoc_2 PF16193.5 KOO26273.1 - 0.22 11.9 1.8 0.27 11.6 0.3 2.0 2 0 0 2 2 2 0 AAA C-terminal domain TPR_7 PF13176.6 KOO26273.1 - 1.2 9.4 5.9 11 6.3 0.1 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat EF-hand_6 PF13405.6 KOO26276.1 - 1.8e-12 46.1 0.9 1.6e-06 27.6 0.3 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO26276.1 - 4e-12 44.8 2.8 1.8e-07 30.2 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO26276.1 - 2.5e-11 43.9 8.7 6.1e-09 36.2 3.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO26276.1 - 7.1e-11 41.1 3.1 2.9e-06 26.5 0.7 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO26276.1 - 4.6e-05 23.2 2.5 0.0035 17.1 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair LRR_6 PF13516.6 KOO26277.1 - 2.3e-07 30.3 0.2 0.00029 20.7 0.0 3.4 3 0 0 3 3 3 2 Leucine Rich repeat NACHT PF05729.12 KOO26277.1 - 3.3e-07 30.4 0.0 6.9e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain APH PF01636.23 KOO26277.1 - 0.0007 19.6 0.3 0.0039 17.1 0.1 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family AAA_16 PF13191.6 KOO26277.1 - 0.0086 16.5 0.7 0.15 12.4 0.1 3.4 3 1 0 3 3 3 1 AAA ATPase domain MutS_III PF05192.18 KOO26277.1 - 0.01 16.1 0.5 0.51 10.5 0.0 2.3 2 0 0 2 2 2 0 MutS domain III LRR_4 PF12799.7 KOO26277.1 - 0.022 15.2 0.0 0.061 13.8 0.0 1.8 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) L27_1 PF09058.10 KOO26277.1 - 0.084 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 L27_1 EF-hand_1 PF00036.32 KOO26278.1 - 7e-16 56.5 2.5 5.6e-07 28.7 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO26278.1 - 1.7e-14 54.0 0.6 2.1e-14 53.7 0.6 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO26278.1 - 8.2e-12 44.1 1.0 7.5e-07 28.6 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO26278.1 - 5.2e-11 41.5 3.0 3.5e-05 23.1 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO26278.1 - 6.6e-11 41.9 3.7 9.7e-08 31.7 0.5 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO26278.1 - 9.2e-06 25.9 0.0 1.1e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO26278.1 - 3.1e-05 24.3 0.2 4e-05 23.9 0.2 1.2 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO26278.1 - 0.00022 21.1 0.2 0.00028 20.8 0.2 1.2 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Adenine_glyco PF03352.13 KOO26278.1 - 0.0031 17.3 0.2 0.0033 17.2 0.2 1.2 1 0 0 1 1 1 1 Methyladenine glycosylase Transcrip_reg PF01709.20 KOO26278.1 - 0.0037 16.7 0.4 0.0037 16.7 0.4 1.2 1 0 0 1 1 1 1 Transcriptional regulator DUF2666 PF10869.8 KOO26278.1 - 0.014 15.6 0.9 0.015 15.5 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) EF-hand_11 PF08976.11 KOO26278.1 - 0.019 15.8 0.0 0.02 15.7 0.0 1.1 1 0 0 1 1 1 0 EF-hand domain HlyD_D4 PF16572.5 KOO26278.1 - 0.14 12.0 0.2 0.93 9.4 0.0 2.0 2 0 0 2 2 2 0 Long alpha hairpin domain of cation efflux system protein, CusB Rhomboid PF01694.22 KOO26279.1 - 4.8e-05 23.4 0.8 0.0001 22.4 0.8 1.5 1 0 0 1 1 1 1 Rhomboid family HEAT_2 PF13646.6 KOO26280.1 - 0.0089 16.4 3.2 0.82 10.1 0.2 2.8 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 KOO26280.1 - 0.016 15.4 10.0 0.049 13.9 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 KOO26280.1 - 0.81 10.3 11.6 5.5 7.6 0.4 3.9 3 2 2 5 5 5 0 HEAT-like repeat PrmC_N PF17827.1 KOO26282.1 - 1.1 9.9 11.0 2 9.1 1.2 3.3 2 0 0 2 2 2 0 PrmC N-terminal domain Pro_isomerase PF00160.21 KOO26283.1 - 4e-07 30.4 0.0 1.6e-06 28.4 0.0 1.8 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SCP2 PF02036.17 KOO26284.1 - 7.7e-10 39.2 1.2 0.042 14.3 0.0 4.5 5 1 0 5 5 5 3 SCP-2 sterol transfer family Ank_2 PF12796.7 KOO26285.1 - 8.7e-09 35.9 0.0 4.6e-08 33.5 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO26285.1 - 2.3e-08 34.1 0.0 9.1e-07 29.0 0.0 2.7 1 1 1 2 2 2 1 Ankyrin repeats (many copies) ADPrib_exo_Tox PF03496.14 KOO26285.1 - 7.8e-07 28.6 0.0 1.7e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Ank_4 PF13637.6 KOO26285.1 - 1e-06 29.2 0.1 0.00023 21.7 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO26285.1 - 1.1e-06 28.4 0.1 0.0093 16.4 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat FCH PF00611.23 KOO26285.1 - 5.1e-05 23.5 0.0 0.00015 22.0 0.0 1.8 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Ank PF00023.30 KOO26285.1 - 0.0001 22.6 0.1 0.0031 17.9 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat ART PF01129.18 KOO26285.1 - 0.00018 20.9 0.0 0.00043 19.6 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_6 PF13516.6 KOO26286.1 - 4.2e-15 54.4 2.8 0.00021 21.1 0.1 3.6 3 0 0 3 3 3 3 Leucine Rich repeat OTU PF02338.19 KOO26286.1 - 1.3e-09 38.6 0.0 5.8e-06 26.8 0.0 2.4 2 0 0 2 2 2 2 OTU-like cysteine protease MORN PF02493.20 KOO26286.1 - 0.00044 20.0 0.1 0.0009 19.0 0.1 1.6 1 0 0 1 1 1 1 MORN repeat Peptidase_C65 PF10275.9 KOO26286.1 - 0.042 13.3 0.1 0.32 10.4 0.0 2.4 3 0 0 3 3 3 0 Peptidase C65 Otubain UIM PF02809.20 KOO26286.1 - 0.05 13.5 2.7 2.6 8.1 0.4 2.9 2 0 0 2 2 2 0 Ubiquitin interaction motif Herpes_teg_N PF04843.12 KOO26286.1 - 0.066 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Herpesvirus tegument protein, N-terminal conserved region Exo84_C PF16528.5 KOO26286.1 - 0.11 12.3 0.1 5.7 6.7 0.0 2.3 2 0 0 2 2 2 0 Exocyst component 84 C-terminal SufE PF02657.15 KOO26286.1 - 0.13 12.1 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 Fe-S metabolism associated domain SpoU_sub_bind PF08032.12 KOO26286.1 - 0.18 12.1 0.2 3 8.2 0.1 3.0 3 1 1 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding OAD_gamma PF04277.13 KOO26286.1 - 9.1 7.0 7.8 1.4 9.5 3.0 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain NTP_transf_2 PF01909.23 KOO26288.1 - 1.5e-10 41.2 0.0 2.5e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 KOO26288.1 - 6.6e-09 35.8 0.0 1.1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Cid1 family poly A polymerase Nrap_D2 PF17403.2 KOO26288.1 - 0.16 11.7 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain UDPG_MGDP_dh_N PF03721.14 KOO26292.1 - 3e-45 154.1 0.0 6.6e-45 153.0 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 KOO26292.1 - 6.1e-29 100.5 0.1 7.1e-28 97.1 0.1 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 KOO26292.1 - 2e-25 88.8 0.0 5e-25 87.5 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Sec63 PF02889.16 KOO26292.1 - 4e-10 39.3 0.0 1.4e-09 37.6 0.0 1.8 1 1 0 1 1 1 1 Sec63 Brl domain NAD_Gly3P_dh_N PF01210.23 KOO26292.1 - 0.0048 16.9 0.5 0.024 14.6 0.1 2.4 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 KOO26292.1 - 0.045 13.4 0.0 0.094 12.4 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF3617 PF12276.8 KOO26292.1 - 0.053 13.8 0.8 0.14 12.5 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3617) Sacchrp_dh_NADP PF03435.18 KOO26292.1 - 0.068 13.4 0.2 0.5 10.6 0.0 2.6 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.17 KOO26292.1 - 0.094 11.9 0.2 0.27 10.5 0.0 1.8 2 0 0 2 2 2 0 Thi4 family AIRS_C PF02769.22 KOO26294.1 - 2.9e-11 43.7 0.0 1.6e-10 41.4 0.0 2.0 1 1 0 1 1 1 1 AIR synthase related protein, C-terminal domain Pkinase PF00069.25 KOO26295.1 - 8e-60 202.4 0.0 1.2e-59 201.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO26295.1 - 2.5e-40 138.4 0.0 4.1e-40 137.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO26295.1 - 6.3e-06 25.7 0.0 1.5e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO26295.1 - 0.017 14.5 0.0 0.19 11.1 0.0 2.5 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOO26295.1 - 0.047 13.3 0.0 1.6 8.3 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Mating_N PF12731.7 KOO26295.1 - 0.072 13.2 1.2 0.32 11.1 0.9 2.2 1 1 1 2 2 2 0 Mating-type protein beta 1 Seadorna_VP7 PF07387.11 KOO26295.1 - 0.12 11.4 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 CENP-F_leu_zip PF10473.9 KOO26295.1 - 1.7 8.7 8.8 5.6 7.0 8.8 1.8 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PfkB PF00294.24 KOO26297.1 - 7.6e-39 133.8 0.0 9.8e-39 133.4 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 KOO26297.1 - 0.00092 18.7 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase RabGAP-TBC PF00566.18 KOO26298.1 - 9.1e-41 139.9 0.0 1.3e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ank_2 PF12796.7 KOO26300.1 - 2.6e-12 47.2 0.1 6e-09 36.4 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO26300.1 - 1.8e-09 37.6 0.0 0.011 16.1 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KOO26300.1 - 1e-07 31.7 0.2 0.0036 17.7 0.0 4.4 4 1 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 KOO26300.1 - 3.7e-06 27.4 0.0 0.02 15.5 0.0 3.5 1 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO26300.1 - 3.2e-05 24.1 0.0 0.057 13.8 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Tna_leader PF08053.11 KOO26300.1 - 0.13 12.2 0.1 0.3 11.1 0.1 1.6 1 0 0 1 1 1 0 Tryptophanase operon leader peptide DUF4440 PF14534.6 KOO26302.1 - 0.021 15.2 0.0 0.033 14.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 KOO26302.1 - 0.12 13.0 0.0 0.26 12.0 0.0 1.5 2 0 0 2 2 2 0 SnoaL-like domain Na_Ca_ex PF01699.24 KOO26303.1 - 9.9e-29 100.2 17.8 1.3e-19 70.6 9.0 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein NEMP PF10225.9 KOO26304.1 - 1.2e-15 57.8 0.8 1.9e-15 57.2 0.8 1.2 1 0 0 1 1 1 1 NEMP family DUF2157 PF09925.9 KOO26304.1 - 0.022 14.6 0.2 0.022 14.6 0.2 2.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) KIAA1430 PF13879.6 KOO26305.1 - 0.00028 21.6 13.9 0.016 16.0 0.1 4.0 2 1 2 4 4 4 3 KIAA1430 homologue C2 PF00168.30 KOO26306.1 - 2.3e-08 34.2 0.0 3.8e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 C2 domain PP2C PF00481.21 KOO26306.1 - 1.1e-07 31.8 0.3 0.00044 20.0 0.0 2.5 2 1 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 KOO26306.1 - 3e-06 27.0 0.5 9.5e-06 25.4 0.2 1.8 2 0 0 2 2 2 1 Protein phosphatase 2C PALP PF00291.25 KOO26308.1 - 1.2e-40 139.8 3.5 1.6e-40 139.4 3.5 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme zf-PARP PF00645.18 KOO26309.1 - 2.2e-14 54.1 0.0 4.2e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region PADR1 PF08063.12 KOO26309.1 - 3.8e-09 36.2 3.1 1.4e-08 34.3 3.1 2.0 1 1 0 1 1 1 1 PADR1 (NUC008) domain TFIIF_alpha PF05793.12 KOO26309.1 - 0.011 14.4 0.9 0.015 13.9 0.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Vps36-NZF-N PF16988.5 KOO26309.1 - 0.042 13.3 1.5 3 7.3 0.0 2.5 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Lar_restr_allev PF14354.6 KOO26309.1 - 0.16 12.3 0.7 3.5 8.1 0.2 2.7 2 0 0 2 2 2 0 Restriction alleviation protein Lar zf-RING_7 PF02591.15 KOO26309.1 - 0.18 12.0 2.4 0.74 10.1 0.7 2.7 2 1 0 2 2 2 0 C4-type zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 KOO26309.1 - 0.21 11.6 3.9 0.69 9.9 2.0 2.4 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_2 PF13240.6 KOO26309.1 - 0.47 10.2 3.3 18 5.2 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 KOO26309.1 - 1.1 8.8 5.1 18 4.9 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Cpn60_TCP1 PF00118.24 KOO26310.1 - 2.6e-65 221.0 4.6 4e-65 220.3 4.6 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family PAS_9 PF13426.7 KOO26311.1 - 4.2e-06 27.0 0.0 6.2e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 KOO26311.1 - 0.0024 17.8 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 KOO26311.1 - 0.078 13.2 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 PAS fold AAA PF00004.29 KOO26312.1 - 3e-26 92.4 0.0 1.2e-17 64.6 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KOO26312.1 - 1.5e-06 28.5 0.1 0.0011 19.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO26312.1 - 6.2e-06 26.5 0.1 0.00059 20.1 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KOO26312.1 - 8.6e-06 26.2 5.2 0.0096 16.3 0.0 4.0 4 1 0 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 KOO26312.1 - 1.2e-05 25.4 0.3 0.0077 16.2 0.1 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KOO26312.1 - 0.0001 22.8 0.0 0.16 12.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 KOO26312.1 - 0.00018 21.3 0.0 0.18 11.5 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 KOO26312.1 - 0.0002 21.3 0.1 0.058 13.3 0.0 2.6 3 0 0 3 3 2 1 Rad17 P-loop domain TIP49 PF06068.13 KOO26312.1 - 0.0012 18.1 0.4 0.13 11.4 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_lid_3 PF17862.1 KOO26312.1 - 0.0027 17.5 0.3 0.63 9.9 0.2 2.7 2 0 0 2 2 2 1 AAA+ lid domain Zot PF05707.12 KOO26312.1 - 0.0028 17.3 0.0 0.014 15.1 0.0 2.1 1 1 1 2 2 2 1 Zonular occludens toxin (Zot) APS_kinase PF01583.20 KOO26312.1 - 0.003 17.5 0.1 0.33 10.8 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase IstB_IS21 PF01695.17 KOO26312.1 - 0.0037 17.0 0.1 0.48 10.1 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KOO26312.1 - 0.0038 17.6 0.0 0.35 11.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_6 PF12774.7 KOO26312.1 - 0.0044 16.0 0.1 0.76 8.7 0.0 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region Mg_chelatase PF01078.21 KOO26312.1 - 0.0057 16.1 0.4 0.41 10.0 0.1 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 KOO26312.1 - 0.008 16.7 0.0 1.3 9.5 0.0 3.4 4 0 0 4 4 4 1 ABC transporter AAA_29 PF13555.6 KOO26312.1 - 0.0086 15.8 0.0 3 7.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 KOO26312.1 - 0.0095 15.4 0.0 0.83 9.0 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain SRP54 PF00448.22 KOO26312.1 - 0.01 15.5 0.1 0.27 10.9 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Cytidylate_kin PF02224.18 KOO26312.1 - 0.013 15.3 0.1 1.9 8.2 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase AAA_14 PF13173.6 KOO26312.1 - 0.018 15.1 0.0 0.085 12.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 KOO26312.1 - 0.023 13.8 0.0 0.1 11.6 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 KOO26312.1 - 0.035 13.4 0.1 0.58 9.4 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 KOO26312.1 - 0.038 13.5 0.0 0.21 11.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 KOO26312.1 - 0.038 13.9 0.1 2.4 8.1 0.0 3.2 3 0 0 3 3 3 0 NACHT domain AAA_17 PF13207.6 KOO26312.1 - 0.053 13.9 0.0 9.8 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KOO26312.1 - 0.056 13.4 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 KOO26312.1 - 0.12 12.1 0.0 0.82 9.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain IPT PF01745.16 KOO26312.1 - 0.12 11.7 0.1 13 5.1 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Sigma54_activat PF00158.26 KOO26312.1 - 0.13 12.0 0.0 2.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 KOO26312.1 - 0.15 11.7 1.1 1.9 8.0 0.1 2.8 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 KOO26312.1 - 0.2 11.1 0.9 3.1 7.2 0.1 2.8 2 1 1 3 3 3 0 PhoH-like protein AAA_30 PF13604.6 KOO26312.1 - 4 7.1 7.9 6.3 6.5 0.1 3.2 4 0 0 4 4 3 0 AAA domain COX8 PF02285.15 KOO26313.1 - 0.038 13.9 0.0 0.17 11.8 0.0 2.2 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIII 4PPT_N PF17837.1 KOO26314.1 - 0.015 15.4 0.0 0.21 11.7 0.0 2.4 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase N-terminal domain Helicase_C PF00271.31 KOO26316.1 - 1.2e-20 73.9 0.0 5.5e-20 71.8 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO26316.1 - 1.4e-18 67.3 0.1 2.6e-18 66.4 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO26316.1 - 0.0047 16.9 0.0 0.0084 16.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit V_ATPase_I PF01496.19 KOO26318.1 - 2.1e-258 859.5 0.0 2.4e-258 859.3 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family LRR_8 PF13855.6 KOO26319.1 - 3.9e-29 100.2 9.1 5.8e-09 35.6 0.2 5.3 3 2 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KOO26319.1 - 3.2e-26 91.0 13.6 5.3e-07 29.9 0.5 6.3 4 2 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO26319.1 - 1.6e-09 37.5 1.9 0.095 12.2 0.0 3.8 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 KOO26319.1 - 0.0055 16.7 7.3 1.7 8.9 0.0 4.6 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 KOO26319.1 - 0.011 16.1 12.0 5.7 7.9 0.4 6.7 6 1 1 7 7 7 0 Leucine Rich Repeat LRR_5 PF13306.6 KOO26319.1 - 0.014 15.4 0.2 2.5 8.1 0.0 3.2 2 1 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) Thioredoxin PF00085.20 KOO26320.1 - 1.1e-31 108.8 0.0 1.9e-31 108.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOO26320.1 - 0.0067 16.9 0.1 0.028 14.9 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 KOO26320.1 - 0.094 12.8 0.0 0.45 10.6 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_8 PF13905.6 KOO26320.1 - 0.19 12.1 0.0 8.9 6.7 0.0 2.6 1 1 1 2 2 2 0 Thioredoxin-like S1 PF00575.23 KOO26321.1 - 9.1e-07 29.1 4.4 0.0018 18.6 0.8 3.6 4 1 0 4 4 4 2 S1 RNA binding domain TOBE_3 PF12857.7 KOO26321.1 - 0.00042 20.2 0.3 0.0013 18.6 0.3 1.9 1 0 0 1 1 1 1 TOBE-like domain RNase_II_C_S1 PF18614.1 KOO26321.1 - 0.087 12.8 12.0 0.12 12.4 0.1 4.0 3 1 0 3 3 3 0 RNase II-type exonuclease C-terminal S1 domain DUF1230 PF06799.11 KOO26322.1 - 3.4e-26 92.1 0.1 4.6e-26 91.7 0.1 1.2 1 0 0 1 1 1 1 Conserved in the green lineage and diatoms 27 SET PF00856.28 KOO26324.1 - 7.6e-06 26.4 0.0 1.3e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 SET domain MORN PF02493.20 KOO26324.1 - 0.011 15.6 3.3 0.011 15.6 3.3 3.1 3 0 0 3 3 3 0 MORN repeat Methyltransf_24 PF13578.6 KOO26325.1 - 2.6e-12 47.7 0.0 5.4e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 KOO26325.1 - 0.055 12.6 0.0 0.38 9.9 0.0 1.9 2 0 0 2 2 2 0 O-methyltransferase Casc1_N PF15927.5 KOO26326.1 - 4e-27 95.2 2.8 5.7e-27 94.7 2.8 1.2 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 N-terminus DUF5005 PF16396.5 KOO26327.1 - 0.032 12.9 0.0 0.048 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5005) DUF1664 PF07889.12 KOO26327.1 - 2.2 8.3 11.9 1 9.4 2.6 3.6 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Pkinase PF00069.25 KOO26328.1 - 8.3e-31 107.3 0.0 1.2e-30 106.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO26328.1 - 2.9e-27 95.6 0.0 4.5e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-C3HC4_3 PF13920.6 KOO26328.1 - 1.1e-09 38.0 6.6 2.6e-09 36.8 6.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PDZ_6 PF17820.1 KOO26328.1 - 2.4e-06 27.3 0.0 9.7e-06 25.3 0.0 2.2 1 0 0 1 1 1 1 PDZ domain zf-RING_2 PF13639.6 KOO26328.1 - 5.7e-05 23.4 6.3 0.00015 22.0 6.3 1.8 1 0 0 1 1 1 1 Ring finger domain PDZ PF00595.24 KOO26328.1 - 0.00016 21.9 0.0 0.00049 20.4 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO26328.1 - 0.0047 17.2 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain zf-C3HC4 PF00097.25 KOO26328.1 - 0.013 15.3 6.3 0.031 14.2 6.3 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO26328.1 - 0.026 14.4 6.0 0.076 12.9 6.0 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOO26328.1 - 0.04 13.9 6.4 0.094 12.7 6.4 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOO26328.1 - 0.14 12.0 7.8 0.28 11.0 6.7 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Ank_2 PF12796.7 KOO26331.1 - 1.9e-22 79.6 8.1 2.3e-13 50.5 0.8 4.6 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ion_trans PF00520.31 KOO26331.1 - 3.4e-15 56.0 8.7 5.1e-15 55.4 8.7 1.2 1 0 0 1 1 1 1 Ion transport protein Ank_5 PF13857.6 KOO26331.1 - 1.3e-14 54.1 10.2 8.5e-05 22.8 0.1 5.9 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO26331.1 - 2.3e-13 49.9 9.2 7.2e-06 26.2 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KOO26331.1 - 2.9e-13 48.7 7.9 0.00055 20.2 0.0 6.4 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 KOO26331.1 - 1.3e-11 44.7 1.0 9.1e-06 26.1 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) BIV_Env PF05858.12 KOO26331.1 - 0.92 7.6 2.9 1.4 7.0 2.9 1.2 1 0 0 1 1 1 0 Bovine immunodeficiency virus surface protein (SU) PDEase_I PF00233.19 KOO26332.1 - 8e-76 254.9 0.2 1.4e-75 254.1 0.2 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Ion_trans PF00520.31 KOO26332.1 - 1.5e-10 40.7 7.2 2.4e-10 40.1 7.2 1.3 1 0 0 1 1 1 1 Ion transport protein PUB PF09409.10 KOO26333.1 - 1.5e-18 66.5 0.0 2.7e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 PUB domain DUF4350 PF14258.6 KOO26333.1 - 0.017 15.6 0.0 0.043 14.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) DUF5343 PF17278.2 KOO26333.1 - 0.018 15.2 0.3 0.027 14.5 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5343) Peptidase_M90 PF06167.12 KOO26334.1 - 0.0035 17.0 0.1 0.01 15.5 0.1 1.8 1 0 0 1 1 1 1 Glucose-regulated metallo-peptidase M90 DUF4478 PF14793.6 KOO26334.1 - 0.0073 16.2 1.7 19 5.2 0.0 4.7 5 0 0 5 5 5 1 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases Sec7 PF01369.20 KOO26334.1 - 0.047 13.4 0.0 2.1 8.0 0.0 3.2 2 0 0 2 2 2 0 Sec7 domain EF-hand_6 PF13405.6 KOO26334.1 - 0.17 11.9 0.3 6.8 6.9 0.0 4.1 3 0 0 3 3 3 0 EF-hand domain CH_2 PF06294.11 KOO26334.1 - 0.83 9.8 6.1 1.1 9.4 0.0 4.0 4 0 0 4 4 4 0 CH-like domain in sperm protein cwf21 PF08312.12 KOO26334.1 - 1.4 9.1 3.4 1.2 9.4 0.5 2.4 3 0 0 3 3 3 0 cwf21 domain Transglut_core2 PF13369.6 KOO26335.1 - 2.2e-40 137.8 0.1 5.9e-40 136.4 0.1 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily Ank_2 PF12796.7 KOO26335.1 - 1.9e-09 37.9 0.0 5e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO26335.1 - 1.3e-07 31.8 0.1 5e-06 26.7 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO26335.1 - 1.9e-06 28.3 0.0 3.2e-05 24.4 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO26335.1 - 1.5e-05 25.0 0.0 0.00014 22.0 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat F-box-like PF12937.7 KOO26335.1 - 0.00012 21.9 0.3 0.00046 20.0 0.3 2.1 1 0 0 1 1 1 1 F-box-like Ank PF00023.30 KOO26335.1 - 0.00039 20.7 0.0 0.0011 19.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat AAA PF00004.29 KOO26336.1 - 4.6e-23 82.1 0.0 6.8e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO26336.1 - 5.7e-12 45.2 0.7 1.4e-11 44.0 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain Vps4_C PF09336.10 KOO26336.1 - 1.9e-08 34.2 0.0 3.3e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain Neur_chan_memb PF02932.16 KOO26337.1 - 4.1e-09 36.8 0.0 6.8e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region EF-hand_1 PF00036.32 KOO26338.1 - 1.3e-10 40.0 3.4 0.027 14.0 0.0 4.2 3 1 1 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO26338.1 - 6.8e-10 39.3 1.0 0.00026 21.4 2.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO26338.1 - 7.6e-08 31.7 2.4 0.007 16.2 0.0 3.8 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO26338.1 - 0.0031 17.3 0.3 0.013 15.3 0.0 2.2 2 1 0 2 2 2 1 EF-hand domain pair PAN_4 PF14295.6 KOO26339.1 - 0.18 11.8 13.0 0.7 9.8 13.0 2.1 1 1 0 1 1 1 0 PAN domain CAP_N PF01213.19 KOO26339.1 - 8.7 5.7 5.6 13 5.1 5.6 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Xpo1 PF08389.12 KOO26340.1 - 1.6e-22 80.2 0.0 3.7e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 Exportin 1-like protein ABC2_membrane PF01061.24 KOO26342.1 - 4.1e-43 147.3 17.5 6.1e-43 146.7 17.5 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 KOO26342.1 - 1.6e-23 83.7 0.0 2.4e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOO26342.1 - 4.8e-05 23.3 0.2 0.14 11.9 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO26342.1 - 0.00017 21.1 0.0 0.00058 19.4 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KOO26342.1 - 0.0012 18.7 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 KOO26342.1 - 0.0065 16.9 0.0 0.014 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 KOO26342.1 - 0.011 15.4 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.7 KOO26342.1 - 0.011 14.8 16.2 0.0085 15.2 14.7 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein AAA_22 PF13401.6 KOO26342.1 - 0.012 15.8 0.0 0.043 14.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOO26342.1 - 0.013 14.5 0.0 0.03 13.4 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 KOO26342.1 - 0.026 14.5 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 KOO26342.1 - 0.07 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KOO26342.1 - 0.088 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain SRP54 PF00448.22 KOO26342.1 - 0.09 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 KOO26342.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KOO26342.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 KOO26342.1 - 0.13 12.7 0.0 0.85 10.0 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KOO26342.1 - 0.15 11.7 0.0 0.76 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KOO26342.1 - 0.17 11.8 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.6 KOO26342.1 - 0.29 11.6 0.0 0.49 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain JSRP PF15312.6 KOO26343.1 - 0.027 14.4 0.5 6.2 6.8 0.0 2.6 2 0 0 2 2 2 0 Junctional sarcoplasmic reticulum protein LRR_5 PF13306.6 KOO26344.1 - 2.3e-137 451.1 0.5 3e-37 127.4 0.1 3.5 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO26344.1 - 2.5e-31 107.2 0.0 0.00033 20.4 0.0 8.5 1 1 11 12 12 12 12 Leucine rich repeat LRR_4 PF12799.7 KOO26344.1 - 8.9e-07 29.1 2.9 63 4.2 0.0 8.3 3 3 4 7 7 7 0 Leucine Rich repeats (2 copies) ZF-HD_dimer PF04770.12 KOO26344.1 - 0.0016 18.7 9.3 11 6.4 0.1 6.4 5 1 1 6 6 6 1 ZF-HD protein dimerisation region TPR_2 PF07719.17 KOO26346.1 - 0.001 19.0 0.1 0.42 10.8 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26346.1 - 0.036 13.9 0.1 2.2 8.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Pyr_redox_2 PF07992.14 KOO26347.1 - 4.3e-54 183.7 1.4 5.2e-54 183.5 1.4 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOO26347.1 - 4.6e-29 100.9 0.4 1.2e-28 99.6 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOO26347.1 - 8.7e-17 61.5 0.7 8.4e-13 48.7 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO26347.1 - 1.7e-09 37.4 4.3 2.8e-08 33.4 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO26347.1 - 3e-08 33.2 2.4 3.4e-06 26.4 0.4 3.2 2 1 2 4 4 4 1 FAD binding domain FAD_oxidored PF12831.7 KOO26347.1 - 0.00021 20.8 0.1 0.00035 20.1 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 KOO26347.1 - 0.00044 19.6 0.4 0.016 14.5 0.1 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KOO26347.1 - 0.0052 15.5 3.2 0.012 14.4 0.6 2.6 4 0 0 4 4 4 1 HI0933-like protein GIDA PF01134.22 KOO26347.1 - 0.0054 15.9 2.6 0.0099 15.0 2.6 1.6 1 1 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 KOO26347.1 - 0.0091 15.3 0.2 0.017 14.4 0.2 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 KOO26347.1 - 0.046 14.0 1.3 0.13 12.6 1.3 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO26347.1 - 0.077 12.6 6.3 2.9 7.4 1.8 3.1 2 1 0 3 3 3 0 FAD dependent oxidoreductase DUF4910 PF16254.5 KOO26347.1 - 0.15 10.9 0.0 0.78 8.6 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4910) Cyd_oper_YbgE PF09600.10 KOO26347.1 - 0.16 12.4 0.1 0.33 11.3 0.1 1.5 1 0 0 1 1 1 0 Cyd operon protein YbgE (Cyd_oper_YbgE) GBR2_CC PF18455.1 KOO26348.1 - 0.071 13.2 0.5 0.13 12.4 0.5 1.5 1 0 0 1 1 1 0 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain DUF1180 PF06679.12 KOO26348.1 - 2.7 8.4 4.5 0.64 10.4 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DUF4191 PF13829.6 KOO26348.1 - 7.8 5.8 6.5 12 5.1 6.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) NAD_binding_10 PF13460.6 KOO26349.1 - 1.8e-23 83.4 0.0 5.2e-23 81.9 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO26349.1 - 7.5e-09 35.5 0.0 1.1e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 KOO26349.1 - 0.00034 20.6 0.1 0.00056 19.9 0.1 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 KOO26349.1 - 0.0027 16.9 0.0 1.2 8.2 0.0 3.0 3 0 0 3 3 3 1 Male sterility protein Epimerase PF01370.21 KOO26349.1 - 0.012 15.0 0.1 0.023 14.2 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO26349.1 - 0.022 13.8 0.0 0.044 12.8 0.0 1.5 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 KOO26349.1 - 0.042 13.2 0.0 0.13 11.6 0.0 1.7 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase LRR_6 PF13516.6 KOO26350.1 - 4.5e-15 54.3 9.3 0.00045 20.0 0.0 6.3 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 KOO26350.1 - 4.7e-06 26.8 1.7 0.57 10.7 0.0 5.1 3 2 2 6 6 6 2 Leucine Rich repeats (2 copies) EF-hand_6 PF13405.6 KOO26350.1 - 0.00021 20.9 0.0 0.00071 19.3 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO26350.1 - 0.0013 18.1 0.0 0.0041 16.6 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO26350.1 - 0.0023 18.3 0.0 0.007 16.8 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO26350.1 - 0.015 14.8 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 EF hand LRR_8 PF13855.6 KOO26350.1 - 0.17 11.7 6.4 14 5.5 1.7 5.0 3 2 0 3 3 3 0 Leucine rich repeat Arm PF00514.23 KOO26351.1 - 1.6e-09 37.4 7.9 0.0002 21.3 0.7 4.8 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat Ion_trans PF00520.31 KOO26352.1 - 1e-24 87.1 6.8 1.6e-24 86.5 6.8 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO26352.1 - 8.3e-11 41.7 4.8 2.8e-10 40.0 4.8 2.0 1 1 0 1 1 1 1 Ion channel cNMP_binding PF00027.29 KOO26352.1 - 3.4e-10 39.8 0.0 1e-09 38.3 0.0 1.9 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain ABC_membrane PF00664.23 KOO26352.1 - 0.0081 15.8 0.2 0.018 14.7 0.0 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region O-FucT PF10250.9 KOO26353.1 - 0.00038 20.3 0.0 0.0012 18.6 0.0 1.7 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase GerD PF17898.1 KOO26354.1 - 0.0023 17.9 11.6 0.0049 16.8 9.0 2.1 2 1 0 2 2 2 1 Spore germination GerD central core domain DnaI_N PF07319.11 KOO26354.1 - 0.0063 17.2 1.8 0.011 16.4 1.8 1.4 1 0 0 1 1 1 1 Primosomal protein DnaI N-terminus DUF445 PF04286.12 KOO26354.1 - 0.034 14.0 0.1 0.042 13.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) PSD4 PF07631.11 KOO26354.1 - 0.063 13.8 3.4 0.14 12.7 3.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1592) STI1 PF17830.1 KOO26354.1 - 4.5 7.3 14.6 4.5 7.3 4.2 3.4 1 1 2 3 3 3 0 STI1 domain ING PF12998.7 KOO26355.1 - 0.0076 16.8 0.7 0.0076 16.8 0.7 2.7 3 0 0 3 3 3 1 Inhibitor of growth proteins N-terminal histone-binding YojJ PF10372.9 KOO26355.1 - 0.51 10.5 1.8 1.3 9.2 0.1 2.5 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus MnmE_helical PF12631.7 KOO26355.1 - 6.6 6.8 17.7 69 3.5 17.7 2.5 1 1 0 1 1 1 0 MnmE helical domain Rpn3_C PF08375.11 KOO26356.1 - 1e-23 83.5 0.3 2.4e-23 82.3 0.3 1.7 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 KOO26356.1 - 4.2e-20 72.2 0.0 8.9e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 KOO26356.1 - 4.1 7.8 7.7 0.21 11.8 0.4 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_transf_24 PF18404.1 KOO26357.1 - 4.3e-126 419.8 0.9 6.2e-126 419.3 0.9 1.2 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_13 PF18401.1 KOO26357.1 - 1.1e-28 99.9 0.2 2.8e-27 95.3 0.0 2.9 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 KOO26357.1 - 1.6e-25 90.1 0.0 2.7e-25 89.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 KOO26357.1 - 8.2e-21 74.2 0.0 1.7e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_14 PF18402.1 KOO26357.1 - 3.9e-18 66.3 0.0 2.3e-11 44.2 0.0 3.5 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_15 PF18403.1 KOO26357.1 - 9.6e-17 61.6 0.0 3.6e-16 59.7 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 KOO26357.1 - 3.2e-05 23.6 0.1 6.2e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 DUF924 PF06041.11 KOO26358.1 - 8.8e-40 136.8 0.0 1.2e-39 136.3 0.0 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) GST_C_3 PF14497.6 KOO26358.1 - 2.7e-11 43.5 0.0 5.6e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOO26358.1 - 5.3e-09 36.3 0.0 9.9e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO26358.1 - 0.002 18.1 0.0 0.0054 16.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOO26358.1 - 0.0062 16.9 0.0 0.016 15.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOO26358.1 - 0.082 13.1 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Prefoldin PF02996.17 KOO26360.1 - 6.1e-28 97.1 2.5 8.2e-28 96.7 2.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit FlxA PF14282.6 KOO26360.1 - 0.012 15.6 7.0 0.023 14.7 2.1 2.1 2 0 0 2 2 2 0 FlxA-like protein CLZ PF16526.5 KOO26360.1 - 0.018 15.4 6.7 0.69 10.3 2.0 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Filament PF00038.21 KOO26360.1 - 0.019 14.6 1.3 1.1 8.8 0.5 2.0 2 0 0 2 2 2 0 Intermediate filament protein AIP3 PF03915.13 KOO26360.1 - 0.12 11.4 3.1 0.22 10.6 3.1 1.3 1 1 0 1 1 1 0 Actin interacting protein 3 Spc24 PF08286.11 KOO26360.1 - 0.16 12.2 0.2 0.16 12.2 0.2 1.9 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Jnk-SapK_ap_N PF09744.9 KOO26360.1 - 0.35 11.1 5.5 0.22 11.8 0.7 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Spectrin PF00435.21 KOO26360.1 - 0.63 10.6 6.9 2.6 8.6 1.7 2.1 2 0 0 2 2 2 0 Spectrin repeat DHR10 PF18595.1 KOO26360.1 - 0.96 9.5 9.4 0.27 11.3 1.0 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Nas2_N PF18265.1 KOO26360.1 - 1.3 9.0 4.5 1.3 9.0 1.3 2.4 2 2 0 2 2 2 0 Nas2 N_terminal domain Spc7 PF08317.11 KOO26360.1 - 1.5 7.6 7.2 0.8 8.5 1.8 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein GIT_CC PF16559.5 KOO26360.1 - 1.9 8.4 11.5 0.12 12.2 3.4 2.5 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor HIP1_clath_bdg PF16515.5 KOO26360.1 - 8.7 7.0 11.8 15 6.2 0.7 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cyclin_N PF00134.23 KOO26361.1 - 1.1e-09 38.1 0.2 1.8e-09 37.4 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF1924 PF09086.11 KOO26361.1 - 0.25 11.7 0.0 0.25 11.7 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1924) Arm PF00514.23 KOO26362.1 - 0.00036 20.5 12.3 0.0051 16.8 0.1 5.7 6 2 0 6 6 6 2 Armadillo/beta-catenin-like repeat Noc2 PF03715.13 KOO26363.1 - 1.9e-60 204.7 3.1 2.6e-37 128.7 0.0 2.0 1 1 1 2 2 2 2 Noc2p family Nop14 PF04147.12 KOO26363.1 - 0.014 13.6 7.7 0.0062 14.8 4.4 1.7 1 1 1 2 2 2 0 Nop14-like family MFS_1 PF07690.16 KOO26364.1 - 4.5e-10 39.0 19.2 5.9e-10 38.6 19.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CCDC66 PF15236.6 KOO26364.1 - 0.0023 17.8 2.8 0.0037 17.1 2.8 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 66 VirB3 PF05101.13 KOO26364.1 - 0.016 15.4 0.9 0.042 14.1 0.9 1.7 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein CRAL_TRIO PF00650.20 KOO26366.1 - 9.5e-27 93.7 0.0 1.2e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KOO26366.1 - 0.13 12.5 0.0 0.27 11.4 0.0 1.6 1 1 0 1 1 1 0 Divergent CRAL/TRIO domain PH PF00169.29 KOO26367.1 - 1.5e-18 67.2 0.0 2.1e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 KOO26367.1 - 0.0008 19.5 0.0 0.0041 17.2 0.0 1.9 1 1 0 1 1 1 1 PH domain PH_13 PF16652.5 KOO26367.1 - 0.0022 17.8 0.3 0.0033 17.3 0.3 1.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 KOO26367.1 - 0.0028 18.0 0.0 0.0061 16.9 0.0 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_4 PF15404.6 KOO26367.1 - 0.0066 16.3 0.1 1.2 8.9 0.0 2.4 1 1 2 3 3 3 2 Pleckstrin homology domain PH_11 PF15413.6 KOO26367.1 - 0.042 14.3 0.6 0.58 10.6 0.6 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain PH_6 PF15406.6 KOO26367.1 - 0.14 12.4 0.1 0.26 11.6 0.0 1.6 2 0 0 2 2 2 0 Pleckstrin homology domain COPIIcoated_ERV PF07970.12 KOO26368.1 - 1.2e-26 94.0 0.0 2.3e-26 93.0 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOO26368.1 - 5.3e-22 78.0 0.9 1.1e-21 77.0 0.9 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.20 KOO26368.1 - 5.1e-18 64.9 0.0 1.1e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOO26368.1 - 0.037 14.5 0.1 0.092 13.2 0.1 1.7 1 0 0 1 1 1 0 Thioredoxin-like domain PG_binding_3 PF09374.10 KOO26369.1 - 0.14 12.4 2.7 0.2 12.0 0.2 2.4 3 0 0 3 3 3 0 Predicted Peptidoglycan domain Snapin_Pallidin PF14712.6 KOO26369.1 - 0.35 11.3 0.0 0.35 11.3 0.0 4.1 3 1 1 4 4 4 0 Snapin/Pallidin DUF1192 PF06698.11 KOO26369.1 - 4.1 7.5 8.5 0.74 9.9 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Mito_carr PF00153.27 KOO26371.1 - 7.4e-58 192.5 1.0 1.4e-18 66.6 0.1 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein V_ATPase_I PF01496.19 KOO26371.1 - 0.019 12.9 1.2 0.029 12.3 1.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 KOO26371.1 - 3.8 7.7 9.3 8.9 6.5 9.3 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HK_sensor PF16750.5 KOO26371.1 - 5.2 7.4 8.0 0.17 12.2 0.9 2.2 2 1 1 3 3 3 0 Sensor domain of 2-component histidine kinase BAF1_ABF1 PF04684.13 KOO26371.1 - 5.8 5.9 10.0 8.2 5.3 10.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF3176 PF11374.8 KOO26373.1 - 0.018 15.3 1.3 0.018 15.3 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3176) MerT PF02411.15 KOO26374.1 - 0.025 14.6 0.4 1.1 9.3 0.0 2.6 2 0 0 2 2 2 0 MerT mercuric transport protein Autophagy_N PF03986.13 KOO26375.1 - 5.8e-42 142.9 0.0 8.7e-42 142.3 0.0 1.2 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 KOO26375.1 - 3.8e-14 51.9 0.6 6.3e-14 51.2 0.6 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 KOO26375.1 - 5.7e-13 49.2 0.4 1.2e-12 48.2 0.1 1.7 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain Actin PF00022.19 KOO26376.1 - 6.5e-89 298.4 0.0 3.5e-88 295.9 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KOO26376.1 - 0.00033 19.6 0.0 0.1 11.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein SUIM_assoc PF16619.5 KOO26376.1 - 0.023 14.7 1.4 0.048 13.7 1.4 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 baeRF_family10 PF18854.1 KOO26376.1 - 0.057 13.7 0.5 2.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 RskA PF10099.9 KOO26376.1 - 0.26 11.6 11.6 1.7 8.9 2.0 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA ThiF PF00899.21 KOO26377.1 - 6.3e-98 327.0 0.0 5.7e-64 215.8 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 KOO26377.1 - 5.6e-92 308.2 0.0 9.1e-92 307.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 KOO26377.1 - 2.6e-32 111.4 0.0 5.8e-32 110.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 KOO26377.1 - 7.9e-23 80.4 0.0 2.1e-22 79.1 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 KOO26377.1 - 5.8e-19 68.1 0.0 1.4e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle LETM1 PF07766.13 KOO26378.1 - 6.5e-32 110.9 0.0 7.2e-17 61.6 0.0 2.1 2 0 0 2 2 2 2 LETM1-like protein UVR PF02151.19 KOO26380.1 - 3.2e-05 23.5 2.9 0.00011 21.8 2.9 2.0 1 0 0 1 1 1 1 UvrB/uvrC motif ERp29 PF07749.12 KOO26380.1 - 0.0018 19.2 2.4 0.0033 18.3 0.1 2.2 2 1 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain PSD4 PF07631.11 KOO26380.1 - 0.033 14.7 0.9 0.068 13.7 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1592) ABC_tran_CTD PF16326.5 KOO26380.1 - 3.1 8.1 10.4 1.5 9.1 2.8 3.1 2 2 1 3 3 3 0 ABC transporter C-terminal domain HSCB_C PF07743.13 KOO26380.1 - 7.8 7.1 7.6 27 5.3 1.2 2.7 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain TPM_phosphatase PF04536.14 KOO26381.1 - 5.9e-06 26.5 0.0 1.3e-05 25.3 0.0 1.5 2 0 0 2 2 2 1 TPM domain cNMP_binding PF00027.29 KOO26382.1 - 2.4e-09 37.1 0.0 3.1e-06 27.2 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Snapin_Pallidin PF14712.6 KOO26382.1 - 0.0016 18.8 0.8 0.0016 18.8 0.8 4.8 2 2 3 5 5 5 2 Snapin/Pallidin FlaC_arch PF05377.11 KOO26382.1 - 0.36 11.2 2.1 18 5.9 0.0 3.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2730 PF10805.8 KOO26382.1 - 7.6 6.7 18.9 0.32 11.1 1.6 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF2730) PP2C PF00481.21 KOO26383.1 - 2.8e-51 174.7 0.0 2e-34 119.4 0.0 3.1 3 0 0 3 3 3 3 Protein phosphatase 2C BTB PF00651.31 KOO26383.1 - 5.2e-24 84.6 0.0 3.1e-23 82.1 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain NHL PF01436.21 KOO26383.1 - 1.7e-15 56.1 9.5 0.00031 20.6 0.0 5.3 5 0 0 5 5 5 4 NHL repeat SGL PF08450.12 KOO26383.1 - 5.6e-10 39.2 1.1 0.028 14.0 0.1 4.5 2 1 2 4 4 4 4 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 KOO26383.1 - 1.9e-05 24.6 1.8 0.18 11.8 0.0 3.4 3 0 0 3 3 3 2 Beta-propeller repeat DUF839 PF05787.13 KOO26383.1 - 0.00091 18.5 1.6 0.71 9.0 0.1 3.1 1 1 3 4 4 4 2 Bacterial protein of unknown function (DUF839) SpoIIE PF07228.12 KOO26383.1 - 0.04 13.8 0.0 0.32 10.9 0.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) WD40 PF00400.32 KOO26383.1 - 0.14 13.0 0.6 1.7 9.7 0.0 3.3 4 0 0 4 4 4 0 WD domain, G-beta repeat Pro_isomerase PF00160.21 KOO26384.1 - 1.1e-44 152.5 0.0 1.6e-44 151.9 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Zeta_toxin PF06414.12 KOO26385.1 - 3.1e-11 42.9 0.0 3.7e-10 39.4 0.0 2.0 1 1 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 KOO26385.1 - 7.3e-06 26.2 0.0 1.3e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOO26385.1 - 0.0019 18.7 0.0 0.0031 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO26385.1 - 0.039 14.5 0.0 0.12 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KOO26385.1 - 0.074 13.3 0.0 0.19 12.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 KOO26385.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase FAP PF07174.11 KOO26386.1 - 0.004 16.6 4.8 0.0053 16.3 4.8 1.2 1 0 0 1 1 1 1 Fibronectin-attachment protein (FAP) WHIM1 PF15612.6 KOO26386.1 - 0.027 14.0 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 LUC7 PF03194.15 KOO26387.1 - 2.2e-25 89.8 0.3 2.6e-25 89.6 0.3 1.1 1 0 0 1 1 1 1 LUC7 N_terminus Sec2p PF06428.11 KOO26387.1 - 0.067 13.2 2.9 0.11 12.5 2.9 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p Nore1-SARAH PF16517.5 KOO26387.1 - 0.086 12.8 0.2 0.31 11.0 0.0 2.0 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain SKA2 PF16740.5 KOO26387.1 - 0.097 12.5 2.9 0.66 9.8 0.4 2.2 1 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 BLOC1_2 PF10046.9 KOO26387.1 - 0.11 12.8 1.6 0.16 12.3 1.0 1.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlxA PF14282.6 KOO26387.1 - 0.21 11.6 4.3 0.1 12.6 1.8 1.7 2 0 0 2 2 2 0 FlxA-like protein DUF4200 PF13863.6 KOO26387.1 - 0.4 11.1 6.6 0.6 10.5 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) MORN PF02493.20 KOO26388.1 - 9.8e-31 103.8 41.5 3.2e-07 29.9 3.8 7.4 7 0 0 7 7 7 7 MORN repeat EF-hand_7 PF13499.6 KOO26388.1 - 0.0014 19.0 0.0 0.003 18.0 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair O-FucT PF10250.9 KOO26389.1 - 9.6e-30 104.4 0.0 2e-29 103.4 0.0 1.4 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase MM_CoA_mutase PF01642.22 KOO26390.1 - 7.6e-213 707.7 0.2 9.1e-213 707.5 0.2 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 KOO26390.1 - 4.2e-16 59.1 2.0 4.8e-16 58.9 0.5 1.9 2 0 0 2 2 2 1 B12 binding domain Aminotran_5 PF00266.19 KOO26391.1 - 4.2e-145 483.4 0.0 5.1e-145 483.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOO26391.1 - 1.7e-07 30.9 0.3 0.00034 20.0 0.1 2.2 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 KOO26391.1 - 2.1e-05 23.2 0.0 7.5e-05 21.4 0.0 1.7 1 1 1 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 KOO26391.1 - 0.0039 16.5 0.1 0.0053 16.1 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase RVT_2 PF07727.14 KOO26393.1 - 0.0037 16.9 0.0 0.0047 16.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PDZ_6 PF17820.1 KOO26394.1 - 1.8e-05 24.5 0.1 2.5e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO26394.1 - 3.2e-05 24.2 0.0 4.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 PDZ domain Arm PF00514.23 KOO26395.1 - 1.3e-21 75.8 47.6 0.00091 19.2 0.9 15.7 18 1 0 18 18 18 6 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 KOO26395.1 - 0.001 18.4 3.7 0.1 11.9 1.0 4.2 2 1 0 3 3 3 1 V-ATPase subunit H UNC45-central PF11701.8 KOO26395.1 - 0.0013 18.7 6.5 2 8.3 0.4 5.0 4 1 0 4 4 4 2 Myosin-binding striated muscle assembly central RICTOR_N PF14664.6 KOO26395.1 - 0.0027 16.7 2.5 0.43 9.5 0.1 3.5 3 0 0 3 3 3 2 Rapamycin-insensitive companion of mTOR, N-term HEAT_2 PF13646.6 KOO26395.1 - 0.011 16.1 46.8 0.17 12.3 0.6 9.8 6 5 4 10 10 10 0 HEAT repeats Arm_2 PF04826.13 KOO26395.1 - 0.043 13.3 0.5 24 4.3 0.1 3.5 2 1 0 3 3 3 0 Armadillo-like CTNNBL PF08216.11 KOO26395.1 - 0.57 10.4 5.2 3 8.0 0.1 4.1 4 1 1 5 5 5 0 Catenin-beta-like, Arm-motif containing nuclear DUF3437 PF11919.8 KOO26395.1 - 0.89 9.5 2.3 64 3.6 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) DUF885 PF05960.11 KOO26395.1 - 1.3 8.6 7.9 0.05 13.2 0.4 2.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF885) Fasciclin PF02469.22 KOO26396.1 - 2e-35 121.8 0.0 3.9e-35 120.9 0.0 1.5 1 0 0 1 1 1 1 Fasciclin domain PAP_fibrillin PF04755.12 KOO26396.1 - 2.3e-15 57.1 0.0 1.9e-07 31.2 0.0 2.5 2 0 0 2 2 2 2 PAP_fibrillin DUF211 PF02680.14 KOO26396.1 - 0.15 12.3 1.8 0.34 11.1 1.8 1.7 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 CH PF00307.31 KOO26397.1 - 3.3e-14 53.0 0.0 5e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain FA_desaturase PF00487.24 KOO26398.1 - 0.11 12.4 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Fatty acid desaturase DUF3094 PF11293.8 KOO26398.1 - 0.18 11.6 0.3 0.18 11.6 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) TadE PF07811.12 KOO26398.1 - 0.95 9.8 5.0 27 5.2 5.0 2.3 1 1 0 1 1 1 0 TadE-like protein Glyco_hydro_2_N PF02837.18 KOO26399.1 - 1.4e-21 77.2 0.0 2.1e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 KOO26399.1 - 1.1e-20 74.0 0.1 1.6e-20 73.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain BetaGal_dom4_5 PF13364.6 KOO26399.1 - 1e-06 29.3 0.2 3.1e-06 27.7 0.0 1.9 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain PRIMA1 PF16101.5 KOO26400.1 - 0.48 10.5 3.8 1.2 9.2 1.4 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 tRNA-synt_2c PF01411.19 KOO26400.1 - 0.71 8.3 3.0 0.97 7.9 3.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class II (A) PC-Esterase PF13839.6 KOO26401.1 - 0.0031 17.3 0.1 0.0031 17.3 0.1 1.1 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p EAR PF07897.11 KOO26401.1 - 0.049 13.3 0.1 0.087 12.5 0.1 1.4 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression Ost5 PF05251.12 KOO26402.1 - 0.4 11.0 11.0 0.16 12.2 3.7 2.8 3 0 0 3 3 3 0 Oligosaccharyltransferase subunit 5 DUF3169 PF11368.8 KOO26402.1 - 1.2 8.6 4.9 9.4 5.7 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3169) Hint PF01079.20 KOO26403.1 - 2e-24 86.3 0.0 2.5e-24 86.0 0.0 1.0 1 0 0 1 1 1 1 Hint module Vint PF14623.6 KOO26403.1 - 0.0028 17.5 0.0 0.0035 17.2 0.0 1.2 1 0 0 1 1 1 1 Hint-domain Intein_splicing PF14890.6 KOO26403.1 - 0.026 14.5 0.0 0.065 13.2 0.0 1.6 1 1 1 2 2 2 0 Intein splicing domain Hint_2 PF13403.6 KOO26403.1 - 0.064 13.5 0.0 0.18 12.1 0.0 1.9 1 1 0 1 1 1 0 Hint domain Peptidase_C2 PF00648.21 KOO26404.1 - 4.4e-63 213.1 0.0 6.1e-63 212.6 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KOO26404.1 - 0.017 15.4 0.0 0.036 14.3 0.0 1.5 1 0 0 1 1 1 0 Calpain large subunit, domain III Tektin PF03148.14 KOO26404.1 - 0.11 11.3 2.8 0.18 10.5 2.8 1.2 1 0 0 1 1 1 0 Tektin family SHIPPO-rpt PF07004.12 KOO26405.1 - 1.8 9.6 15.1 1.2 10.2 1.3 3.8 4 0 0 4 4 4 0 Sperm-tail PG-rich repeat AAA PF00004.29 KOO26406.1 - 3.7e-39 134.2 0.0 6.1e-39 133.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO26406.1 - 1.4e-10 40.8 0.2 3.6e-10 39.5 0.2 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 KOO26406.1 - 1.5e-06 28.0 0.0 2.6e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO26406.1 - 0.00012 22.5 0.2 0.00065 20.1 0.2 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 KOO26406.1 - 0.0002 21.2 0.0 0.00034 20.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Vps4_C PF09336.10 KOO26406.1 - 0.00031 20.7 0.0 0.00064 19.7 0.0 1.5 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 KOO26406.1 - 0.00032 20.0 0.0 0.00049 19.4 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 KOO26406.1 - 0.00034 20.9 0.4 0.051 13.9 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 KOO26406.1 - 0.00052 20.0 0.0 0.002 18.1 0.0 2.1 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KOO26406.1 - 0.0035 16.9 0.0 0.014 15.0 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 KOO26406.1 - 0.0055 16.5 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KOO26406.1 - 0.0067 16.8 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 KOO26406.1 - 0.008 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KOO26406.1 - 0.0097 16.5 0.4 0.022 15.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.6 KOO26406.1 - 0.011 15.8 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOO26406.1 - 0.014 15.0 2.1 0.16 11.5 0.2 2.8 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 KOO26406.1 - 0.017 14.8 0.0 0.55 9.9 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain LisH PF08513.11 KOO26406.1 - 0.02 14.9 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 LisH ATPase PF06745.13 KOO26406.1 - 0.028 13.8 0.1 0.61 9.4 0.1 2.2 1 1 1 2 2 2 0 KaiC AAA_33 PF13671.6 KOO26406.1 - 0.029 14.5 0.0 0.057 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 KOO26406.1 - 0.058 12.5 0.0 0.096 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.16 KOO26406.1 - 0.062 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 KOO26406.1 - 0.079 12.0 0.1 0.13 11.4 0.1 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 KOO26406.1 - 0.083 13.1 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 KOO26406.1 - 0.11 12.4 0.0 0.35 10.7 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 KOO26406.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bac_DnaA PF00308.18 KOO26406.1 - 0.14 11.9 0.0 0.37 10.6 0.0 1.6 1 1 0 1 1 1 0 Bacterial dnaA protein NACHT PF05729.12 KOO26406.1 - 0.14 12.0 0.0 0.53 10.2 0.0 1.9 1 1 1 2 2 2 0 NACHT domain DUF2075 PF09848.9 KOO26406.1 - 0.24 10.6 0.0 0.39 9.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) 2-Hacid_dh_C PF02826.19 KOO26409.1 - 9.8e-37 126.0 0.0 1.3e-22 80.0 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOO26409.1 - 3.9e-11 42.7 0.0 4.6e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOO26409.1 - 0.0051 17.0 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ThiF PF00899.21 KOO26409.1 - 0.02 14.3 0.3 0.033 13.6 0.3 1.3 1 0 0 1 1 1 0 ThiF family IlvN PF07991.12 KOO26409.1 - 0.025 14.1 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 KOO26409.1 - 0.066 13.8 0.9 0.096 13.3 0.0 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent CS PF04969.16 KOO26411.1 - 1.2e-09 39.1 0.2 1.8e-09 38.5 0.2 1.3 1 0 0 1 1 1 1 CS domain LAP1C PF05609.12 KOO26411.1 - 0.012 14.7 0.7 0.016 14.3 0.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4407 PF14362.6 KOO26411.1 - 0.066 12.6 2.5 0.095 12.0 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ctr PF04145.15 KOO26411.1 - 0.068 13.8 0.1 0.12 13.0 0.1 1.4 1 0 0 1 1 1 0 Ctr copper transporter family MCM_bind PF09739.9 KOO26411.1 - 0.18 10.2 0.7 0.23 9.8 0.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Connexin PF00029.19 KOO26411.1 - 0.19 11.5 0.3 0.26 11.0 0.3 1.3 1 0 0 1 1 1 0 Connexin DUF4692 PF15763.5 KOO26411.1 - 0.33 11.4 1.6 0.49 10.9 1.6 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Porph_ging PF09697.10 KOO26411.1 - 0.6 10.7 4.2 8 7.1 4.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (Porph_ging) Tox-ART-HYE1 PF15634.6 KOO26411.1 - 0.65 9.3 1.9 0.91 8.8 1.9 1.1 1 0 0 1 1 1 0 HYE1 signature containing ADP-ribosyltransferase NARP1 PF12569.8 KOO26411.1 - 3.8 6.3 10.5 5.2 5.9 10.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 KOO26412.1 - 2.1e-13 49.2 1.1 5.2e-07 29.3 0.1 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26412.1 - 2.7e-12 45.9 0.2 4.1e-05 23.2 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO26412.1 - 1.6e-11 43.7 0.0 5.8e-06 25.9 0.0 2.9 2 0 0 2 2 2 2 TPR repeat TPR_14 PF13428.6 KOO26412.1 - 4.9e-09 36.3 7.4 1.6e-05 25.3 0.5 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO26412.1 - 1e-07 31.5 0.8 0.00093 19.1 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO26412.1 - 1.1e-07 32.0 7.5 9.5e-07 29.0 1.6 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO26412.1 - 4.9e-07 29.7 1.5 0.0033 17.7 0.0 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO26412.1 - 3.2e-05 24.5 5.3 0.024 15.3 0.7 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO26412.1 - 8.7e-05 22.6 7.6 0.0023 18.0 0.9 2.6 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26412.1 - 0.00012 22.0 0.5 0.05 13.8 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26412.1 - 0.00042 20.8 1.5 0.013 16.0 0.5 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat 2OG-FeII_Oxy_3 PF13640.6 KOO26412.1 - 0.002 19.0 0.0 0.0039 18.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_15 PF13429.6 KOO26412.1 - 0.0027 17.0 0.5 0.43 9.8 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO26412.1 - 0.0065 16.3 8.3 0.35 10.8 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26412.1 - 0.061 14.0 0.8 12 6.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PhyH PF05721.13 KOO26412.1 - 0.15 12.3 0.8 11 6.2 0.0 2.7 2 1 1 3 3 3 0 Phytanoyl-CoA dioxygenase (PhyH) RPN7 PF10602.9 KOO26412.1 - 0.17 11.6 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN7 Beach PF02138.18 KOO26413.1 - 4.6e-116 387.0 0.1 6.1e-116 386.6 0.1 1.1 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 KOO26413.1 - 2e-12 47.1 0.0 3.7e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 KOO26413.1 - 1.2e-06 29.1 11.5 0.00011 22.9 0.5 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat Laminin_G_3 PF13385.6 KOO26413.1 - 0.0015 18.7 0.0 0.0039 17.4 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily GRAM PF02893.20 KOO26413.1 - 0.044 13.7 0.0 0.099 12.5 0.0 1.5 1 0 0 1 1 1 0 GRAM domain zf-RING_2 PF13639.6 KOO26414.1 - 1.1e-10 41.7 15.1 1.5e-10 41.2 15.1 1.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KOO26414.1 - 1.3e-07 31.7 12.3 3e-07 30.6 12.3 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KOO26414.1 - 3.3e-06 26.8 14.3 5.3e-06 26.2 14.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOO26414.1 - 5.8e-06 25.9 14.8 5.8e-06 25.9 14.8 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 KOO26414.1 - 0.00023 21.0 14.2 0.00034 20.4 14.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO26414.1 - 0.0057 16.6 15.1 0.0085 16.0 15.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOO26414.1 - 0.079 12.8 11.9 0.13 12.2 11.9 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KOO26414.1 - 0.085 12.9 10.0 0.19 11.8 10.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 KOO26414.1 - 3.9 7.6 13.0 6.6 6.8 13.0 1.4 1 0 0 1 1 1 0 RING-type zinc-finger RINGv PF12906.7 KOO26414.1 - 7.6 6.7 15.7 12 6.1 15.7 1.3 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 KOO26414.1 - 8.3 6.7 15.5 2.4e+02 2.0 15.5 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain Cut12 PF11500.8 KOO26416.1 - 2.9 7.9 6.9 19 5.2 0.6 3.1 2 1 1 3 3 3 0 Spindle pole body formation-associated protein Spc7 PF08317.11 KOO26416.1 - 3.2 6.5 13.4 6.4 5.5 0.7 2.5 2 1 0 2 2 2 0 Spc7 kinetochore protein T3SSipB PF16535.5 KOO26416.1 - 9.7 6.7 20.8 6.8 7.1 7.4 3.0 2 0 0 2 2 2 0 Type III cell invasion protein SipB Ank_2 PF12796.7 KOO26417.1 - 2.2e-06 28.2 2.1 0.0055 17.3 0.0 4.0 4 1 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO26417.1 - 3.6e-05 23.8 0.6 0.16 12.6 0.0 5.2 4 1 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 KOO26417.1 - 0.025 14.9 0.1 1 9.7 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO26417.1 - 0.04 14.5 0.4 2.1 9.0 0.0 3.7 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Ion_trans PF00520.31 KOO26417.1 - 0.29 10.3 10.3 0.56 9.4 9.0 2.0 2 1 0 2 2 2 0 Ion transport protein Na_H_Exchanger PF00999.21 KOO26421.1 - 7.7e-56 189.5 32.7 2.1e-55 188.1 32.7 1.6 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family Sulfatase PF00884.23 KOO26421.1 - 7.2e-12 45.3 0.8 1.3e-11 44.4 0.8 1.3 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KOO26421.1 - 0.08 13.7 0.0 0.16 12.7 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase SET PF00856.28 KOO26422.1 - 2.9e-09 37.5 0.0 4.9e-08 33.5 0.0 2.1 1 1 0 1 1 1 1 SET domain Oxysterol_BP PF01237.18 KOO26424.1 - 2.8e-34 118.6 0.0 4.7e-30 104.7 0.0 2.3 2 0 0 2 2 2 2 Oxysterol-binding protein BTB PF00651.31 KOO26425.1 - 0.018 15.3 0.0 0.096 12.9 0.0 2.0 1 1 1 2 2 2 0 BTB/POZ domain Filament PF00038.21 KOO26426.1 - 2.8 7.4 14.4 0.16 11.5 3.1 3.5 4 0 0 4 4 4 0 Intermediate filament protein GREB1 PF15782.5 KOO26426.1 - 3.1 4.8 5.8 4.6 4.2 5.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ResIII PF04851.15 KOO26427.1 - 1e-05 25.6 0.1 0.01 15.9 0.0 3.8 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Nup84_Nup100 PF04121.13 KOO26427.1 - 0.0016 16.6 0.2 0.0033 15.6 0.2 1.4 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 PhoH PF02562.16 KOO26427.1 - 0.0021 17.5 0.0 0.0044 16.5 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein AAA_16 PF13191.6 KOO26427.1 - 0.23 11.8 0.0 0.23 11.8 0.0 4.2 3 1 0 3 3 3 0 AAA ATPase domain AAA_19 PF13245.6 KOO26427.1 - 4 7.8 7.1 6.8 7.0 0.0 3.9 3 1 0 3 3 3 0 AAA domain La PF05383.17 KOO26428.1 - 1.3e-18 66.8 0.0 2.4e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 La domain Lactamase_B_2 PF12706.7 KOO26428.1 - 4e-14 52.6 2.4 8.8e-14 51.5 2.4 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain GCK PF07802.11 KOO26429.1 - 1.3e-20 73.6 1.9 2e-20 73.0 1.9 1.3 1 0 0 1 1 1 1 GCK domain CX9C PF16860.5 KOO26429.1 - 0.038 14.0 1.1 0.25 11.4 0.0 2.3 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cystatin PF00031.21 KOO26430.1 - 8.2e-05 22.8 0.1 0.00014 22.1 0.1 1.4 1 0 0 1 1 1 1 Cystatin domain Nitr_red_assoc PF09655.10 KOO26430.1 - 0.13 12.9 0.0 0.15 12.7 0.0 1.1 1 0 0 1 1 1 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) THOC7 PF05615.13 KOO26431.1 - 1.2e-24 87.1 9.9 1.2e-24 87.1 9.9 1.6 1 1 1 2 2 2 1 Tho complex subunit 7 DUF4407 PF14362.6 KOO26431.1 - 0.0001 21.8 5.9 0.00011 21.7 5.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) TolA_bind_tri PF16331.5 KOO26431.1 - 0.00042 20.3 10.3 0.26 11.4 0.1 2.4 1 1 1 2 2 2 2 TolA binding protein trimerisation DUF2730 PF10805.8 KOO26431.1 - 0.021 14.9 2.6 0.081 13.0 1.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) AAA_13 PF13166.6 KOO26431.1 - 0.024 13.3 3.3 0.026 13.2 3.3 1.1 1 0 0 1 1 1 0 AAA domain Lzipper-MIP1 PF14389.6 KOO26431.1 - 0.042 14.1 11.0 0.1 12.9 3.8 2.6 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Adenine_glyco PF03352.13 KOO26431.1 - 0.058 13.2 1.7 0.095 12.5 1.1 1.6 1 1 0 1 1 1 0 Methyladenine glycosylase DUF2634 PF10934.8 KOO26431.1 - 0.06 13.5 0.8 0.2 11.8 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2634) GBP_C PF02841.14 KOO26431.1 - 0.08 12.3 11.3 0.28 10.5 11.3 1.7 1 1 0 1 1 1 0 Guanylate-binding protein, C-terminal domain SlyX PF04102.12 KOO26431.1 - 0.15 12.7 9.5 1.2 9.7 3.7 3.3 1 1 2 3 3 3 0 SlyX FliJ PF02050.16 KOO26431.1 - 0.24 11.6 11.5 0.9 9.8 4.4 3.0 1 1 2 3 3 3 0 Flagellar FliJ protein HAUS6_N PF14661.6 KOO26431.1 - 0.27 10.8 5.1 0.36 10.4 5.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Exonuc_VII_L PF02601.15 KOO26431.1 - 0.32 10.5 5.8 0.38 10.3 5.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5082 PF16888.5 KOO26431.1 - 0.33 11.2 9.9 7.8 6.8 0.2 3.0 1 1 1 3 3 3 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 KOO26431.1 - 0.57 10.7 12.8 0.46 11.0 3.2 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region MbeB_N PF04837.12 KOO26431.1 - 0.66 10.3 6.5 12 6.3 0.1 3.6 4 0 0 4 4 4 0 MbeB-like, N-term conserved region FlaC_arch PF05377.11 KOO26431.1 - 0.69 10.3 3.4 10 6.6 0.3 2.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF406 PF04175.12 KOO26431.1 - 0.84 10.2 6.0 0.27 11.7 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF406) DUF1192 PF06698.11 KOO26431.1 - 0.91 9.6 6.5 0.76 9.9 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) HIP1_clath_bdg PF16515.5 KOO26431.1 - 2 9.1 11.4 7.1 7.3 0.3 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3347 PF11827.8 KOO26431.1 - 2.1 8.5 6.8 2 8.6 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) DUF4200 PF13863.6 KOO26431.1 - 3.6 8.0 12.5 1.7 9.0 0.1 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF4200) OmpH PF03938.14 KOO26431.1 - 9 6.6 12.9 1.4 9.2 7.6 2.1 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Ion_trans PF00520.31 KOO26433.1 - 1.5e-91 306.0 20.7 1.6e-48 165.1 13.5 2.2 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 KOO26433.1 - 1.6e-10 40.2 17.7 0.00086 18.1 0.1 5.0 5 1 0 5 5 5 3 Polycystin cation channel GPHH PF16905.5 KOO26433.1 - 0.00024 20.8 0.1 0.00097 18.9 0.0 2.1 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.27 KOO26433.1 - 0.22 11.4 0.6 0.68 9.9 0.6 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Methyltransf_23 PF13489.6 KOO26434.1 - 0.086 12.7 0.0 0.14 12.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.10 KOO26434.1 - 0.19 11.4 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit LRR_6 PF13516.6 KOO26435.1 - 4.8e-06 26.2 11.5 0.0016 18.4 0.5 4.9 5 0 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.7 KOO26435.1 - 0.0018 18.6 8.4 1.9 9.0 0.2 4.3 3 2 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO26435.1 - 0.0048 17.2 0.8 54 4.9 0.2 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO26435.1 - 0.03 14.1 5.4 4 7.3 0.1 4.0 3 2 0 3 3 3 0 Leucine rich repeat Pyr_redox PF00070.27 KOO26436.1 - 7.8e-08 32.8 0.0 1.2e-06 29.0 0.0 2.7 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOO26436.1 - 3.7e-07 29.7 0.0 6.7e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO26436.1 - 1.7e-05 24.6 0.8 0.046 13.3 0.5 2.6 1 1 1 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 KOO26436.1 - 0.0019 17.0 0.0 0.0029 16.4 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 KOO26436.1 - 0.0025 17.1 0.1 0.0064 15.8 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 KOO26436.1 - 0.0029 16.9 0.0 0.0044 16.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOO26436.1 - 0.0045 17.2 0.1 0.013 15.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO26436.1 - 0.015 14.4 0.1 0.031 13.4 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain NAD_binding_7 PF13241.6 KOO26436.1 - 0.078 13.4 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Pkinase PF00069.25 KOO26437.1 - 9.3e-27 94.0 0.0 1e-26 93.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO26437.1 - 2.7e-20 72.7 0.0 3.3e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO26437.1 - 2.1e-05 24.6 0.5 0.00016 21.7 0.3 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO26437.1 - 6.1e-05 22.0 0.0 6.1e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO26437.1 - 0.00062 19.2 0.1 0.0008 18.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOO26437.1 - 0.019 14.6 0.0 0.037 13.7 0.0 1.6 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 KOO26437.1 - 0.042 13.4 0.0 0.045 13.3 0.0 1.3 1 1 0 1 1 1 0 RIO1 family Methyltransf_21 PF05050.12 KOO26440.1 - 0.024 14.6 0.0 0.031 14.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase FkbM domain SET PF00856.28 KOO26441.1 - 1.6e-10 41.6 0.0 2.7e-10 40.9 0.0 1.3 1 1 0 1 1 1 1 SET domain FKBP_C PF00254.28 KOO26442.1 - 3.3e-23 81.8 0.0 6.2e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PDZ_2 PF13180.6 KOO26442.1 - 3.9e-08 33.5 0.5 2e-07 31.2 0.2 2.0 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KOO26442.1 - 1e-06 28.4 2.3 2.5e-06 27.2 2.3 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO26442.1 - 1.2e-06 28.7 0.0 2.6e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Thioredoxin PF00085.20 KOO26443.1 - 6.7e-07 29.2 0.0 1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KOO26443.1 - 8.7e-06 25.3 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Calsequestrin PF01216.17 KOO26443.1 - 0.0027 16.8 0.0 0.0033 16.5 0.0 1.1 1 0 0 1 1 1 1 Calsequestrin HyaE PF07449.11 KOO26443.1 - 0.03 14.3 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE OAD_gamma PF04277.13 KOO26443.1 - 0.068 13.8 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Tachylectin PF14517.6 KOO26443.1 - 0.1 12.1 0.0 7.2 6.1 0.0 2.3 2 0 0 2 2 2 0 Tachylectin Ion_trans PF00520.31 KOO26444.1 - 1.1e-84 283.6 8.2 1.6e-51 174.9 0.1 2.1 2 0 0 2 2 2 2 Ion transport protein T2SSG PF08334.11 KOO26444.1 - 0.062 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G 2OG-FeII_Oxy_2 PF13532.6 KOO26445.1 - 6.2e-13 49.4 0.0 2.3e-12 47.5 0.0 1.7 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF2407_C PF13373.6 KOO26446.1 - 0.0019 18.4 0.1 0.0041 17.3 0.1 1.5 1 0 0 1 1 1 1 DUF2407 C-terminal domain Cep57_CLD_2 PF14197.6 KOO26446.1 - 0.0035 17.4 1.0 0.0081 16.2 1.0 1.6 1 0 0 1 1 1 1 Centrosome localisation domain of PPC89 LPP PF04728.13 KOO26446.1 - 0.0088 16.4 0.4 0.028 14.8 0.4 1.8 1 0 0 1 1 1 1 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 KOO26446.1 - 0.023 14.7 2.4 0.044 13.8 2.4 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 KOO26446.1 - 0.029 13.3 0.6 0.043 12.7 0.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2353 PF09789.9 KOO26446.1 - 0.039 13.3 0.1 0.07 12.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DUF3037 PF11236.8 KOO26446.1 - 0.041 14.3 2.3 0.07 13.6 0.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3037) TolA_bind_tri PF16331.5 KOO26446.1 - 0.043 13.9 0.9 0.11 12.7 0.9 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation IF-2B PF01008.17 KOO26446.1 - 0.05 12.8 0.1 0.068 12.4 0.1 1.2 1 0 0 1 1 1 0 Initiation factor 2 subunit family EB1 PF03271.17 KOO26446.1 - 0.07 13.4 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 EB1-like C-terminal motif ZapB PF06005.12 KOO26446.1 - 0.14 12.6 2.7 0.5 10.8 0.7 2.3 2 0 0 2 2 2 0 Cell division protein ZapB NADH-G_4Fe-4S_3 PF10588.9 KOO26446.1 - 0.26 10.9 3.4 0.48 10.0 0.1 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Cep57_MT_bd PF06657.13 KOO26446.1 - 6.6 7.3 10.2 9.9 6.7 1.4 3.2 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Filamin PF00630.19 KOO26447.1 - 3.8e-20 72.6 0.0 1.5e-16 61.0 0.0 2.4 2 1 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO26447.1 - 0.033 14.5 0.0 0.07 13.5 0.0 1.6 1 0 0 1 1 1 0 Invasin, domain 3 Neurexophilin PF06312.12 KOO26447.1 - 0.14 11.6 0.0 0.41 10.1 0.0 1.7 2 0 0 2 2 2 0 Neurexophilin His_Phos_1 PF00300.22 KOO26448.1 - 2.7e-05 24.0 2.0 0.00069 19.4 0.8 3.4 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) YozD PF14162.6 KOO26448.1 - 0.16 12.3 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 YozD-like protein Pepdidase_M14_N PF18027.1 KOO26449.1 - 8.4e-33 113.0 0.1 1.4e-32 112.2 0.1 1.4 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain EF-hand_6 PF13405.6 KOO26449.1 - 4.7e-12 44.8 1.9 1.2e-06 27.9 0.5 2.6 2 0 0 2 2 2 2 EF-hand domain Peptidase_M14 PF00246.24 KOO26449.1 - 6.5e-11 42.6 0.0 1.6e-10 41.3 0.0 1.6 2 0 0 2 2 2 1 Zinc carboxypeptidase EF-hand_1 PF00036.32 KOO26449.1 - 4.4e-10 38.4 5.6 3.5e-06 26.2 0.5 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO26449.1 - 4.3e-08 32.3 6.6 2.6e-05 23.5 1.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO26449.1 - 2.8e-07 30.9 3.1 5.2e-07 30.0 3.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO26449.1 - 5.3e-06 26.2 2.1 0.0001 22.1 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair Filamin PF00630.19 KOO26450.1 - 5.2e-23 81.8 0.0 3.2e-05 24.7 0.0 5.0 4 1 0 4 4 4 4 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO26450.1 - 2.2e-06 27.9 0.2 0.00013 22.2 0.0 3.4 3 0 0 3 3 3 1 Invasin, domain 3 Ion_trans PF00520.31 KOO26451.1 - 5.9e-28 97.7 1.3 8.5e-28 97.2 1.3 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO26451.1 - 8.9e-09 35.2 3.9 8.9e-09 35.2 3.9 2.1 2 0 0 2 2 2 1 Ion channel Homeodomain PF00046.29 KOO26452.1 - 5.5e-17 61.4 0.4 9.6e-17 60.6 0.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOO26452.1 - 0.0063 16.4 0.5 0.012 15.5 0.5 1.4 1 0 0 1 1 1 1 Homeobox KN domain Rhomboid PF01694.22 KOO26454.1 - 1.4e-28 99.8 10.2 1.4e-28 99.8 10.2 1.6 2 0 0 2 2 2 1 Rhomboid family IQ PF00612.27 KOO26454.1 - 0.001 18.7 0.2 0.001 18.7 0.2 2.9 3 0 0 3 3 3 1 IQ calmodulin-binding motif GAT PF03127.14 KOO26454.1 - 0.068 13.5 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 GAT domain IQ PF00612.27 KOO26456.1 - 0.14 12.0 0.1 0.14 12.0 0.1 1.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif DIT1_PvcA PF05141.12 KOO26458.1 - 0.12 11.8 1.7 0.17 11.3 1.7 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein CSRNP_N PF16019.5 KOO26458.1 - 0.16 11.9 4.5 0.22 11.4 4.5 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus FapA PF03961.13 KOO26458.1 - 1.8 7.1 4.3 1.3 7.5 2.5 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A PRKG1_interact PF15898.5 KOO26458.1 - 3.6 8.6 11.4 13 6.8 1.6 2.4 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain MutS_III PF05192.18 KOO26458.1 - 7.7 6.7 7.3 13 6.0 7.4 1.4 1 1 0 1 1 1 0 MutS domain III SHIPPO-rpt PF07004.12 KOO26459.1 - 2.5e-12 47.1 21.0 0.0037 18.1 0.1 6.5 6 0 0 6 6 6 5 Sperm-tail PG-rich repeat ECR1_N PF14382.6 KOO26459.1 - 6.7e-05 22.6 2.7 0.041 13.7 0.0 4.0 4 0 0 4 4 4 2 Exosome complex exonuclease RRP4 N-terminal region DUF719 PF05334.13 KOO26459.1 - 6.6 6.9 6.2 13 5.9 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF719) DUF2849 PF11011.8 KOO26459.1 - 9.2 7.0 9.1 0.45 11.2 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2849) C2 PF00168.30 KOO26461.1 - 5.5e-15 55.5 0.1 9.8e-15 54.7 0.1 1.4 1 0 0 1 1 1 1 C2 domain Peptidase_M10 PF00413.24 KOO26461.1 - 0.0013 18.7 0.0 0.87 9.4 0.0 3.3 3 0 0 3 3 3 1 Matrixin Metallopep PF12044.8 KOO26461.1 - 0.097 11.3 0.8 0.17 10.5 0.8 1.3 1 0 0 1 1 1 0 Putative peptidase family EF-hand_5 PF13202.6 KOO26461.1 - 0.13 11.9 0.1 0.31 10.6 0.1 1.6 1 0 0 1 1 1 0 EF hand Ceramidase PF05875.12 KOO26461.1 - 0.14 11.5 3.0 0.075 12.4 0.6 1.6 2 0 0 2 2 2 0 Ceramidase DUF2304 PF10066.9 KOO26461.1 - 3.1 8.1 5.1 7.4 6.8 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Ank_4 PF13637.6 KOO26462.1 - 1.3e-19 70.2 10.5 0.00077 20.0 0.5 5.8 3 1 3 6 6 6 5 Ankyrin repeats (many copies) FYVE PF01363.21 KOO26462.1 - 7.5e-18 64.4 6.6 1.4e-17 63.6 6.6 1.4 1 0 0 1 1 1 1 FYVE zinc finger Ank_5 PF13857.6 KOO26462.1 - 2.1e-15 56.6 8.6 3.2e-08 33.7 0.1 4.6 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO26462.1 - 4.4e-15 55.4 20.9 0.0017 18.7 0.3 7.8 7 1 0 7 7 7 5 Ankyrin repeat Ank_2 PF12796.7 KOO26462.1 - 2.1e-14 53.9 5.1 8.9e-07 29.4 0.3 5.0 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO26462.1 - 5.9e-13 47.7 11.2 0.018 15.5 0.1 7.9 8 0 0 8 8 8 3 Ankyrin repeat BACK PF07707.15 KOO26462.1 - 0.01 15.9 0.1 0.15 12.2 0.0 2.3 2 0 0 2 2 2 0 BTB And C-terminal Kelch FYVE_2 PF02318.16 KOO26462.1 - 0.01 16.1 4.9 0.018 15.2 4.9 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger zf-C2HC_2 PF13913.6 KOO26463.1 - 9.3e-10 38.2 2.1 1.5e-09 37.5 2.1 1.3 1 0 0 1 1 1 1 zinc-finger of a C2HC-type ORC6 PF05460.13 KOO26463.1 - 1.4 8.1 7.2 1.8 7.7 7.2 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) GST_C_2 PF13410.6 KOO26464.1 - 1.4e-05 25.0 0.1 4.1e-05 23.5 0.1 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOO26464.1 - 0.004 17.3 0.0 0.017 15.3 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 KOO26464.1 - 0.0042 16.8 0.1 0.011 15.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Glyco_transf_20 PF00982.21 KOO26465.1 - 1.1e-112 377.2 0.0 3.5e-67 227.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOO26465.1 - 6.4e-48 162.9 0.0 9.1e-48 162.4 0.0 1.2 1 0 0 1 1 1 1 Trehalose-phosphatase CBM_20 PF00686.19 KOO26465.1 - 6.1e-14 51.7 0.0 1.3e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Starch binding domain Hydrolase_3 PF08282.12 KOO26465.1 - 0.0009 19.0 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glycos_transf_1 PF00534.20 KOO26465.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF2117 PF09890.9 KOO26465.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) OTU PF02338.19 KOO26470.1 - 1.7e-08 35.0 0.2 4.6e-07 30.4 0.0 2.6 3 0 0 3 3 3 1 OTU-like cysteine protease CBFB_NFYA PF02045.15 KOO26470.1 - 5.1 7.8 6.6 3.6 8.3 0.1 2.7 2 0 0 2 2 2 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Methyltransf_21 PF05050.12 KOO26471.1 - 3e-06 27.4 0.0 7e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase FkbM domain PNP_UDP_1 PF01048.20 KOO26472.1 - 1.1e-35 123.1 1.5 1.2e-35 122.8 0.4 1.5 2 0 0 2 2 2 1 Phosphorylase superfamily Chloroa_b-bind PF00504.21 KOO26473.1 - 5.7e-30 105.0 0.1 7.2e-30 104.6 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein EF-hand_7 PF13499.6 KOO26474.1 - 4.5e-14 52.6 0.1 1.3e-11 44.7 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO26474.1 - 8.2e-10 38.4 0.6 1e-05 25.3 0.0 3.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO26474.1 - 1.2e-08 33.9 0.1 0.0051 16.3 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO26474.1 - 3.3e-06 26.6 1.6 0.013 15.4 0.1 3.7 3 1 1 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KOO26474.1 - 9.7e-05 21.7 0.7 0.12 11.9 0.1 4.0 4 0 0 4 4 4 1 EF hand Collagen PF01391.18 KOO26474.1 - 0.022 14.5 7.0 0.043 13.6 7.0 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) PTS_2-RNA PF01885.16 KOO26474.1 - 0.18 11.8 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Glu_synthase PF01645.17 KOO26475.1 - 1.6e-71 241.4 0.8 2.4e-71 240.8 0.8 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase TPR_12 PF13424.6 KOO26475.1 - 7.3e-23 80.7 28.3 1.9e-08 34.4 3.8 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat CHAT PF12770.7 KOO26475.1 - 1.4e-19 70.6 0.2 4.5e-19 69.0 0.2 1.8 1 0 0 1 1 1 1 CHAT domain TPR_2 PF07719.17 KOO26475.1 - 2e-08 33.7 18.6 2.9 8.2 0.0 8.7 9 1 1 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26475.1 - 1.3e-06 28.1 8.3 2.7 8.4 0.3 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26475.1 - 2.5e-06 27.1 5.0 1 9.3 0.0 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO26475.1 - 0.00032 20.2 12.1 0.00032 20.2 12.1 3.1 2 1 1 3 3 3 2 MalT-like TPR region TPR_10 PF13374.6 KOO26475.1 - 0.00055 19.7 18.7 0.1 12.5 0.3 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat RPN7 PF10602.9 KOO26475.1 - 0.0065 16.2 0.3 0.17 11.6 0.0 2.6 2 1 1 3 3 3 1 26S proteasome subunit RPN7 TPR_11 PF13414.6 KOO26475.1 - 0.0091 15.7 2.4 0.97 9.2 0.0 5.1 7 0 0 7 7 7 1 TPR repeat TPR_14 PF13428.6 KOO26475.1 - 0.018 15.8 26.9 0.5 11.3 0.6 7.5 8 1 1 9 9 7 0 Tetratricopeptide repeat FMN_dh PF01070.18 KOO26475.1 - 0.019 14.0 0.4 0.041 12.9 0.4 1.5 1 0 0 1 1 1 0 FMN-dependent dehydrogenase DUF1180 PF06679.12 KOO26475.1 - 1.7 9.1 5.3 9 6.7 4.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) TPR_6 PF13174.6 KOO26475.1 - 9.2 7.1 16.1 1.4e+02 3.4 0.0 6.4 5 1 0 5 5 5 0 Tetratricopeptide repeat LRR_6 PF13516.6 KOO26476.1 - 1.3e-45 149.5 16.0 0.00064 19.6 0.0 11.7 11 0 0 11 11 11 11 Leucine Rich repeat NACHT PF05729.12 KOO26476.1 - 7.8e-05 22.6 0.1 0.00026 20.9 0.1 1.9 1 1 0 1 1 1 1 NACHT domain NUDIX PF00293.28 KOO26476.1 - 0.00039 20.5 0.5 0.0015 18.6 0.5 2.0 1 0 0 1 1 1 1 NUDIX domain Kdo PF06293.14 KOO26476.1 - 0.0006 19.2 0.0 0.0043 16.4 0.0 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family EcKinase PF02958.20 KOO26476.1 - 0.00071 19.0 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase AAA_16 PF13191.6 KOO26476.1 - 0.0023 18.4 0.2 0.0023 18.4 0.2 3.7 3 0 0 3 3 3 1 AAA ATPase domain RRM_1 PF00076.22 KOO26476.1 - 0.019 14.7 0.0 0.058 13.2 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RIO1 PF01163.22 KOO26476.1 - 0.026 14.1 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family AAA_19 PF13245.6 KOO26476.1 - 0.038 14.3 0.2 1.8 8.9 0.0 3.5 5 0 0 5 5 5 0 AAA domain DUF4523 PF15023.6 KOO26476.1 - 0.19 11.6 0.0 0.35 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) WD40 PF00400.32 KOO26477.1 - 2.8e-27 94.4 17.8 0.0094 16.8 0.1 15.3 18 0 0 18 18 18 7 WD domain, G-beta repeat DUF667 PF05018.13 KOO26477.1 - 2.9e-20 72.8 0.0 4e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF667) ANAPC4_WD40 PF12894.7 KOO26477.1 - 8.8e-16 58.0 0.0 0.0029 17.9 0.0 9.6 10 1 1 11 11 11 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 KOO26477.1 - 0.0013 17.3 0.0 0.088 11.3 0.0 3.5 4 1 1 5 5 5 1 Cytochrome D1 heme domain WD40_like PF17005.5 KOO26477.1 - 0.0064 15.9 0.0 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 WD40-like domain RAB3GAP2_N PF14655.6 KOO26477.1 - 0.019 14.3 0.0 0.39 9.9 0.0 2.5 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus HELP PF03451.14 KOO26477.1 - 0.1 12.5 0.0 0.31 10.9 0.0 1.8 1 0 0 1 1 1 0 HELP motif DUF4586 PF15239.6 KOO26478.1 - 7.3e-34 118.3 10.6 9.3e-34 118.0 10.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) Sugar_tr PF00083.24 KOO26479.1 - 3.6e-41 141.5 18.2 3.2e-37 128.5 12.9 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOO26479.1 - 3.3e-14 52.6 21.6 3.3e-14 52.6 21.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Glyco_transf_8 PF01501.20 KOO26480.1 - 0.59 9.7 3.8 0.4 10.2 0.9 1.9 2 0 0 2 2 2 0 Glycosyl transferase family 8 Glyco_transf_54 PF04666.13 KOO26481.1 - 0.029 13.2 0.0 0.038 12.9 0.0 1.1 1 0 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glyco_transf_25 PF01755.17 KOO26481.1 - 0.071 13.0 0.0 0.097 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Myosin_head PF00063.21 KOO26482.1 - 9.5e-186 619.0 0.0 1.4e-185 618.4 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) PH PF00169.29 KOO26482.1 - 0.0011 19.4 0.0 0.0031 18.0 0.0 1.8 1 1 0 1 1 1 1 PH domain FliG_C PF01706.16 KOO26482.1 - 8.1 6.7 5.8 36 4.6 0.1 2.9 3 0 0 3 3 3 0 FliG C-terminal domain CBF PF03914.17 KOO26483.1 - 7.1e-16 58.7 2.6 8.6e-07 29.1 0.0 2.5 2 0 0 2 2 2 2 CBF/Mak21 family Pyr_redox_2 PF07992.14 KOO26485.1 - 0.00013 21.3 0.0 0.00013 21.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO26485.1 - 0.00022 21.7 0.0 0.0023 18.4 0.0 2.5 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO26485.1 - 0.00028 20.3 0.2 0.00047 19.5 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO26485.1 - 0.0033 16.7 0.1 0.0033 16.7 0.1 3.1 4 0 0 4 4 4 1 FAD binding domain FAD_binding_2 PF00890.24 KOO26485.1 - 0.0053 15.9 0.4 0.0053 15.9 0.4 2.4 2 1 1 3 3 3 1 FAD binding domain HI0933_like PF03486.14 KOO26485.1 - 0.015 14.0 0.1 0.015 14.0 0.1 2.3 3 0 0 3 3 3 0 HI0933-like protein DAO PF01266.24 KOO26485.1 - 0.023 14.3 0.9 0.023 14.3 0.9 3.3 2 1 1 3 3 3 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 KOO26485.1 - 0.25 11.8 0.0 0.25 11.8 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding FAM60A PF15396.6 KOO26485.1 - 0.5 10.3 1.5 0.91 9.5 1.5 1.3 1 0 0 1 1 1 0 Protein Family FAM60A UQ_con PF00179.26 KOO26486.1 - 2.4e-45 153.6 0.0 2.9e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA PF00627.31 KOO26486.1 - 9.9e-11 41.3 0.1 3.2e-10 39.7 0.0 1.9 2 0 0 2 2 2 1 UBA/TS-N domain Prok-E2_B PF14461.6 KOO26486.1 - 2.7e-06 27.1 0.0 3.9e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B UBA_3 PF09288.10 KOO26486.1 - 0.00079 19.2 0.0 0.0022 17.8 0.0 1.6 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain HOIP-UBA PF16678.5 KOO26486.1 - 0.0021 18.1 0.1 0.0032 17.5 0.1 1.3 1 0 0 1 1 1 1 HOIP UBA domain pair RWD PF05773.22 KOO26486.1 - 0.0052 17.1 0.0 0.0074 16.6 0.0 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KOO26486.1 - 0.12 12.2 0.2 0.26 11.1 0.2 1.6 1 1 0 1 1 1 0 UEV domain CUE PF02845.16 KOO26486.1 - 0.33 10.7 1.3 0.72 9.6 0.0 2.0 2 0 0 2 2 2 0 CUE domain AIG1 PF04548.16 KOO26487.1 - 8.7e-11 41.6 0.0 1.1e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 KOO26487.1 - 0.0063 16.6 0.0 0.0079 16.3 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase PGK PF00162.19 KOO26488.1 - 2.1e-160 533.8 0.2 2.6e-160 533.5 0.2 1.1 1 0 0 1 1 1 1 Phosphoglycerate kinase PrpR_N PF06506.11 KOO26488.1 - 0.033 13.8 0.3 0.63 9.6 0.0 2.8 2 1 1 3 3 3 0 Propionate catabolism activator Cupin_3 PF05899.12 KOO26489.1 - 5.6e-07 29.2 0.3 3.5e-06 26.6 0.3 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF861) TraB PF01963.17 KOO26490.1 - 3.4e-07 30.4 0.3 4.5e-07 30.0 0.3 1.2 1 1 0 1 1 1 1 TraB family Laminin_II PF06009.12 KOO26492.1 - 0.00049 20.1 2.4 0.00098 19.1 2.4 1.5 1 0 0 1 1 1 1 Laminin Domain II Seryl_tRNA_N PF02403.22 KOO26492.1 - 0.022 15.0 2.7 0.022 15.0 2.7 1.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Extensin_2 PF04554.13 KOO26492.1 - 0.034 14.2 35.0 0.041 14.0 34.1 1.6 1 1 0 1 1 1 0 Extensin-like region Cnn_1N PF07989.11 KOO26492.1 - 0.084 13.0 4.3 1.9 8.7 0.2 2.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 FlaC_arch PF05377.11 KOO26492.1 - 0.17 12.3 0.1 3.1 8.3 0.0 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) bZIP_1 PF00170.21 KOO26492.1 - 0.18 11.9 10.5 0.54 10.4 0.3 3.1 3 0 0 3 3 3 0 bZIP transcription factor DUF4407 PF14362.6 KOO26492.1 - 0.21 10.9 14.7 0.29 10.4 14.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4200 PF13863.6 KOO26492.1 - 0.29 11.5 11.7 0.041 14.3 5.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) SPATA1_C PF15743.5 KOO26492.1 - 0.33 11.0 10.3 0.057 13.5 2.7 2.6 2 1 1 3 3 3 0 Spermatogenesis-associated C-terminus CENP-F_leu_zip PF10473.9 KOO26492.1 - 0.63 10.1 9.8 0.27 11.3 4.5 2.4 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin PF00261.20 KOO26492.1 - 0.9 8.9 20.9 0.85 8.9 6.0 3.0 2 1 1 3 3 3 0 Tropomyosin GAS PF13851.6 KOO26492.1 - 1.2 8.5 9.1 2.5 7.4 9.1 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 KOO26492.1 - 1.5 7.7 11.3 0.16 10.9 5.2 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Uds1 PF15456.6 KOO26492.1 - 2.7 8.1 16.3 1.6 8.9 3.6 2.7 1 1 2 3 3 3 0 Up-regulated During Septation ATG16 PF08614.11 KOO26492.1 - 3.4 7.8 20.5 0.053 13.8 10.6 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 KOO26492.1 - 3.6 5.0 16.5 5.4 4.4 16.5 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4472 PF14739.6 KOO26492.1 - 4.8 8.0 12.4 0.48 11.2 3.7 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) Spc24 PF08286.11 KOO26492.1 - 4.9 7.4 5.0 1.1e+02 3.1 5.0 2.6 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 TPT PF03151.16 KOO26493.1 - 2.8e-13 49.9 21.7 3.2e-13 49.7 21.7 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO26493.1 - 1.1e-11 45.0 35.2 1.3e-06 28.7 16.5 2.1 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO26493.1 - 9.4e-08 31.6 19.9 1.9e-07 30.6 19.9 1.5 1 1 0 1 1 1 1 UAA transporter family ATP_bind_1 PF03029.17 KOO26494.1 - 7e-76 255.2 0.0 9.3e-76 254.8 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 KOO26494.1 - 2e-07 30.7 0.0 2.1e-06 27.4 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOO26494.1 - 1.1e-05 25.0 0.0 0.00044 19.8 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 KOO26494.1 - 1.7e-05 24.9 0.0 8.8e-05 22.6 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 KOO26494.1 - 4.2e-05 23.3 0.1 0.00012 21.8 0.0 1.7 2 0 0 2 2 1 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 KOO26494.1 - 4.3e-05 23.0 0.0 0.026 14.0 0.0 2.2 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KOO26494.1 - 7e-05 23.3 0.0 0.00016 22.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 KOO26494.1 - 0.00013 22.5 0.0 0.0022 18.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO26494.1 - 0.00015 22.1 0.0 0.00041 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Arf PF00025.21 KOO26494.1 - 0.00033 20.1 0.0 0.052 13.0 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family NACHT PF05729.12 KOO26494.1 - 0.00055 19.9 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_30 PF13604.6 KOO26494.1 - 0.00075 19.3 0.1 0.002 17.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO26494.1 - 0.0011 19.1 0.0 0.0025 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 KOO26494.1 - 0.0016 17.6 0.0 0.0032 16.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain SRP54 PF00448.22 KOO26494.1 - 0.0021 17.7 0.0 0.0059 16.3 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_5 PF07728.14 KOO26494.1 - 0.0031 17.5 0.0 0.0067 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 KOO26494.1 - 0.0038 17.5 0.0 0.027 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 KOO26494.1 - 0.006 16.6 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 KOO26494.1 - 0.0065 16.1 0.2 0.038 13.6 0.2 2.1 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 KOO26494.1 - 0.0073 16.2 0.1 0.98 9.3 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase MeaB PF03308.16 KOO26494.1 - 0.013 14.5 0.0 0.71 8.8 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 KOO26494.1 - 0.014 15.6 0.0 0.33 11.2 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 KOO26494.1 - 0.016 14.7 0.2 0.07 12.6 0.0 2.1 3 0 0 3 3 3 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 KOO26494.1 - 0.017 14.4 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 KOO26494.1 - 0.036 14.4 0.0 0.075 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 KOO26494.1 - 0.043 13.7 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.6 KOO26494.1 - 0.047 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ras PF00071.22 KOO26494.1 - 0.05 13.2 0.0 8.5 5.9 0.0 2.2 2 0 0 2 2 2 0 Ras family APS_kinase PF01583.20 KOO26494.1 - 0.057 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_24 PF13479.6 KOO26494.1 - 0.084 12.6 0.0 0.17 11.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 KOO26494.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase KTI12 PF08433.10 KOO26494.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Mg_chelatase PF01078.21 KOO26494.1 - 0.15 11.4 0.0 0.55 9.6 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.18 KOO26494.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 KOO26494.1 - 0.18 12.3 0.0 0.41 11.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 KOO26494.1 - 0.19 12.2 2.2 0.64 10.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 KOO26494.1 - 0.21 11.5 0.0 0.43 10.5 0.0 1.5 1 0 0 1 1 1 0 NTPase Pox_A32 PF04665.12 KOO26494.1 - 0.23 10.9 0.0 2.8 7.3 0.0 2.1 2 0 0 2 2 2 0 Poxvirus A32 protein MAP65_ASE1 PF03999.12 KOO26496.1 - 0.017 13.8 0.2 0.018 13.8 0.2 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) VWA PF00092.28 KOO26497.1 - 4.8e-29 101.8 0.0 6.9e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KOO26497.1 - 2.7e-15 56.9 0.2 1e-14 55.1 0.1 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF493 PF04359.14 KOO26497.1 - 7.1e-09 36.1 0.0 1.9e-08 34.7 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF493) VWA_CoxE PF05762.14 KOO26497.1 - 0.051 12.9 0.1 1.2 8.5 0.0 2.1 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein PSI_integrin PF17205.3 KOO26497.1 - 0.11 12.3 6.6 0.41 10.4 6.6 2.1 1 0 0 1 1 1 0 Integrin plexin domain VWA_3 PF13768.6 KOO26497.1 - 0.14 12.0 0.1 0.78 9.7 0.0 2.2 2 1 0 2 2 2 0 von Willebrand factor type A domain DUF3584 PF12128.8 KOO26498.1 - 0.0015 16.2 39.5 0.0023 15.5 8.3 2.1 1 1 0 2 2 2 2 Protein of unknown function (DUF3584) Filament PF00038.21 KOO26498.1 - 0.0028 17.3 36.7 0.053 13.1 11.8 3.2 1 1 2 3 3 3 3 Intermediate filament protein IFT20 PF14931.6 KOO26498.1 - 0.0036 17.5 4.4 0.0036 17.5 4.4 3.3 2 1 1 3 3 3 2 Intraflagellar transport complex B, subunit 20 YabA PF06156.13 KOO26498.1 - 0.041 14.5 1.5 0.041 14.5 1.5 4.0 1 1 1 3 3 3 0 Initiation control protein YabA Mating_N PF12731.7 KOO26498.1 - 0.12 12.5 8.1 0.27 11.4 0.4 3.7 3 2 1 4 4 4 0 Mating-type protein beta 1 V_ATPase_I PF01496.19 KOO26498.1 - 0.17 9.8 13.2 0.22 9.4 13.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5631 PF18645.1 KOO26498.1 - 0.19 12.1 4.6 0.45 10.9 0.1 3.4 2 2 1 3 3 3 0 Family of unknown function (DUF5631) Baculo_PEP_C PF04513.12 KOO26498.1 - 1 9.4 20.2 1.8 8.6 3.4 4.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMP_2 PF06791.13 KOO26498.1 - 4.4 6.9 15.7 16 5.1 11.4 3.6 1 1 2 3 3 3 0 Prophage tail length tape measure protein ERM PF00769.19 KOO26498.1 - 6.8 6.4 42.2 8.7 6.1 18.0 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family PhzC-PhzF PF02567.16 KOO26499.1 - 1.7e-44 152.4 0.0 2.2e-24 86.4 0.0 2.0 2 0 0 2 2 2 2 Phenazine biosynthesis-like protein MGDG_synth PF06925.11 KOO26501.1 - 4.8e-28 98.4 0.0 6.4e-28 98.0 0.0 1.2 1 0 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.16 KOO26501.1 - 2.9e-15 56.6 0.0 5.5e-15 55.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glycos_transf_1 PF00534.20 KOO26501.1 - 1.3e-05 24.8 0.0 2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOO26501.1 - 0.00035 21.0 0.0 0.00074 20.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Epimerase_2 PF02350.19 KOO26501.1 - 0.078 11.8 0.0 0.16 10.8 0.0 1.6 1 1 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase TPR_12 PF13424.6 KOO26502.1 - 1.3e-08 35.0 8.7 5.3e-05 23.4 0.6 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO26502.1 - 1.7e-05 24.6 6.5 0.74 10.1 0.0 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26502.1 - 0.0023 18.0 0.6 0.39 11.0 0.3 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO26502.1 - 0.037 13.4 7.0 0.06 12.7 7.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region TPR_19 PF14559.6 KOO26502.1 - 0.092 13.3 8.8 1.4 9.4 2.8 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat ApbA_C PF08546.11 KOO26502.1 - 0.18 12.0 0.6 2.4 8.3 0.2 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal TPR_1 PF00515.28 KOO26502.1 - 0.19 11.6 5.5 10 6.1 0.3 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26502.1 - 0.29 11.8 10.4 21 6.0 0.0 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO26502.1 - 0.31 12.0 10.2 2.6 9.1 0.3 4.7 2 1 3 5 5 5 0 Tetratricopeptide repeat DUF1180 PF06679.12 KOO26502.1 - 0.59 10.5 5.3 1.1 9.7 5.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SHOCT PF09851.9 KOO26503.1 - 0.062 13.0 1.7 0.062 13.0 1.7 2.6 2 0 0 2 2 2 0 Short C-terminal domain zf-HC2 PF13490.6 KOO26503.1 - 0.21 11.9 1.9 7.3 6.9 0.3 3.3 3 0 0 3 3 3 0 Putative zinc-finger FMN_dh PF01070.18 KOO26504.1 - 0.049 12.6 5.9 0.098 11.7 5.9 1.5 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Sugar_tr PF00083.24 KOO26505.1 - 3.6e-41 141.5 18.2 3.2e-37 128.5 12.9 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOO26505.1 - 3.3e-14 52.6 21.6 3.3e-14 52.6 21.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily EF-hand_5 PF13202.6 KOO26506.1 - 6e-19 66.6 0.0 8.2e-05 21.9 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO26506.1 - 7.5e-16 56.7 0.0 0.00065 19.4 0.0 3.9 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO26506.1 - 1.7e-15 55.3 0.0 0.0005 19.4 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO26506.1 - 2.3e-11 44.0 0.1 0.037 14.5 0.0 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO26506.1 - 3.7e-06 26.7 0.0 0.03 14.2 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain pair Toprim_2 PF13155.6 KOO26506.1 - 0.0092 16.4 0.4 6.8 7.2 0.0 3.3 3 0 0 3 3 3 1 Toprim-like Pan3_PK PF18101.1 KOO26506.1 - 0.012 15.6 0.0 3.6 7.6 0.0 2.6 3 0 0 3 3 3 0 Pan3 Pseudokinase domain EF-hand_9 PF14658.6 KOO26506.1 - 0.017 15.4 0.0 28 5.1 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain zf-H2C2_2 PF13465.6 KOO26507.1 - 3.3e-06 27.3 5.8 4.2e-05 23.8 0.2 4.0 4 0 0 4 4 4 2 Zinc-finger double domain TPT PF03151.16 KOO26508.1 - 1.2e-46 159.4 22.0 1.5e-46 159.1 22.0 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO26508.1 - 8.3e-15 55.2 30.8 1.6e-09 38.0 9.1 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO26508.1 - 4.5e-12 45.8 18.6 7.9e-12 45.0 18.7 1.3 1 1 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 KOO26508.1 - 0.00043 19.6 25.4 0.14 11.4 25.4 2.3 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport TMEM234 PF10639.9 KOO26508.1 - 0.0043 17.1 1.1 0.0043 17.1 1.1 2.5 2 0 0 2 2 2 1 Putative transmembrane family 234 Nuc_sug_transp PF04142.15 KOO26508.1 - 4 6.5 14.4 2.2 7.4 3.5 2.3 2 0 0 2 2 2 0 Nucleotide-sugar transporter Multi_Drug_Res PF00893.19 KOO26508.1 - 6 7.6 15.0 2.5 8.8 2.1 3.1 3 0 0 3 3 3 0 Small Multidrug Resistance protein ADH_zinc_N PF00107.26 KOO26510.1 - 2.2e-15 56.8 0.1 5e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOO26510.1 - 2.6e-13 51.2 0.1 7.5e-13 49.7 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Palm_thioest PF02089.15 KOO26511.1 - 2e-23 83.5 0.0 2.2e-23 83.4 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 KOO26511.1 - 0.017 14.8 0.1 0.024 14.3 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2939 PF11159.8 KOO26511.1 - 0.068 13.6 0.6 9.6 6.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2939) ThiF PF00899.21 KOO26512.1 - 4.2e-20 72.1 0.0 1.3e-19 70.5 0.0 2.0 1 1 0 1 1 1 1 ThiF family Radial_spoke PF04712.12 KOO26513.1 - 2.9e-99 333.3 0.3 3.1e-97 326.6 0.3 2.0 1 1 0 1 1 1 1 Radial spokehead-like protein GrpE PF01025.19 KOO26514.1 - 8.2e-23 80.9 0.0 1.1e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 GrpE FA_FANCE PF11510.8 KOO26515.1 - 7.4e-14 51.7 4.8 9.5e-14 51.4 4.8 1.1 1 0 0 1 1 1 1 Fanconi Anaemia group E protein FANCE PikAIV_N PF18605.1 KOO26515.1 - 0.021 14.4 1.1 0.037 13.6 0.1 2.0 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain DUF3072 PF11272.8 KOO26515.1 - 0.062 13.2 0.4 2.1 8.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3072) DUF1462 PF07315.11 KOO26516.1 - 0.22 11.8 0.5 1.4 9.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1462) Choline_transpo PF04515.12 KOO26517.1 - 2.9e-44 151.6 34.2 2.9e-44 151.6 34.2 2.7 3 0 0 3 3 3 1 Plasma-membrane choline transporter ESSS PF10183.9 KOO26517.1 - 0.53 10.5 1.5 2.2 8.6 1.5 2.0 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) COX6C PF02937.15 KOO26517.1 - 0.96 9.6 2.6 4.2 7.6 2.6 2.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc DLH PF01738.18 KOO26518.1 - 8.4e-31 107.2 0.0 1.3e-30 106.6 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 KOO26518.1 - 5.8e-06 26.3 0.0 2.7e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KOO26518.1 - 0.0084 15.6 0.0 0.19 11.2 0.0 2.1 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 KOO26518.1 - 0.016 15.1 0.1 0.26 11.1 0.0 2.6 2 1 1 3 3 3 0 alpha/beta hydrolase fold EF-hand_7 PF13499.6 KOO26518.1 - 0.026 15.0 0.6 0.088 13.3 0.2 2.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 KOO26518.1 - 0.073 12.6 0.1 0.21 11.2 0.1 1.8 1 0 0 1 1 1 0 EF hand DUF3035 PF11233.8 KOO26518.1 - 0.082 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3035) BAAT_C PF08840.11 KOO26518.1 - 0.2 11.6 0.1 11 5.9 0.0 2.6 1 1 2 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal TMEM138 PF14935.6 KOO26520.1 - 0.0012 19.5 0.2 0.0022 18.6 0.2 1.4 1 0 0 1 1 1 1 Transmembrane protein 138 Pro_isomerase PF00160.21 KOO26521.1 - 1.6e-44 151.9 0.0 2e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD USP19_linker PF16602.5 KOO26522.1 - 0.078 13.5 0.1 0.16 12.5 0.1 1.5 1 0 0 1 1 1 0 Linker region of USP19 deubiquitinase EF-hand_1 PF00036.32 KOO26523.1 - 1.3e-09 36.9 1.2 0.0018 17.7 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO26523.1 - 3.7e-09 35.8 3.2 0.00088 19.0 0.1 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 KOO26523.1 - 3.2e-06 27.5 4.2 0.012 16.1 0.2 3.3 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO26523.1 - 5e-05 22.6 1.1 0.22 11.1 0.1 3.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO26523.1 - 0.00049 19.9 7.4 0.016 15.1 0.1 3.4 3 1 0 3 3 3 2 EF-hand domain pair LXG PF04740.12 KOO26523.1 - 0.0083 15.9 4.9 0.21 11.3 0.2 2.9 3 0 0 3 3 3 2 LXG domain of WXG superfamily PapC_N PF13954.6 KOO26523.1 - 0.17 11.9 1.7 3.1 7.8 0.0 2.5 2 0 0 2 2 2 0 PapC N-terminal domain Fasciclin PF02469.22 KOO26524.1 - 1.4e-35 122.3 0.1 2.1e-35 121.7 0.1 1.3 1 0 0 1 1 1 1 Fasciclin domain DUF1840 PF08895.11 KOO26526.1 - 1 9.7 5.6 0.23 11.8 0.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1840) DUF4140 PF13600.6 KOO26526.1 - 1.6 9.2 11.0 0.15 12.5 1.1 3.1 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Nop10p PF04135.12 KOO26527.1 - 4.4e-22 77.9 0.3 5.5e-22 77.6 0.3 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family TPR_14 PF13428.6 KOO26528.1 - 2.4e-13 49.7 10.2 4.1e-05 24.0 1.3 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO26528.1 - 8.6e-11 41.1 2.8 0.0026 17.8 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO26528.1 - 6.4e-09 36.3 6.8 0.00019 22.0 0.5 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO26528.1 - 1.9e-08 34.3 5.4 0.0025 17.9 2.0 2.5 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26528.1 - 2.4e-08 34.4 1.2 4.5e-05 23.9 0.0 2.4 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_21 PF09976.9 KOO26528.1 - 6.3e-08 32.5 0.3 8.8e-08 32.1 0.3 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 KOO26528.1 - 2.9e-06 27.1 0.0 2 8.8 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO26528.1 - 7.1e-06 25.6 0.1 0.26 11.0 0.1 3.1 1 1 2 3 3 3 2 TPR repeat TPR_1 PF00515.28 KOO26528.1 - 8.3e-06 25.4 0.1 0.072 13.0 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO26528.1 - 1.7e-05 24.9 0.9 0.11 12.9 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO26528.1 - 2.6e-05 23.6 1.7 0.026 13.7 0.3 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO26528.1 - 0.00067 19.9 2.7 0.68 10.3 0.2 2.3 2 1 0 2 2 2 2 Tetratricopeptide repeat NARP1 PF12569.8 KOO26528.1 - 0.024 13.5 0.0 5.6 5.7 0.0 1.7 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 MIT PF04212.18 KOO26528.1 - 0.025 14.7 0.3 4.8 7.3 0.5 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 KOO26528.1 - 0.026 14.6 1.0 2 8.6 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26528.1 - 0.038 14.6 1.5 4.8 8.0 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.22 KOO26529.1 - 2.9e-16 59.0 0.1 4e-16 58.6 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO26529.1 - 0.084 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif GIDA PF01134.22 KOO26530.1 - 5.9e-108 361.4 0.0 1.1e-107 360.5 0.0 1.5 1 1 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 KOO26530.1 - 2.4e-60 204.3 0.0 5.2e-60 203.2 0.0 1.5 1 1 0 1 1 1 1 GidA associated domain Exostosin PF03016.15 KOO26531.1 - 2.8e-12 46.5 0.0 5.1e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Exostosin family Pkinase PF00069.25 KOO26533.1 - 1.6e-65 221.1 0.0 2.1e-65 220.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO26533.1 - 9.2e-28 97.2 0.0 3.4e-27 95.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO26533.1 - 0.00017 21.0 0.0 0.00028 20.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO26533.1 - 0.00098 18.5 0.1 0.0019 17.6 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOO26533.1 - 0.0089 15.7 0.1 0.018 14.7 0.1 1.6 1 1 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 KOO26533.1 - 0.011 15.3 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 KOO26533.1 - 0.021 13.6 2.1 0.066 12.0 0.1 2.3 2 1 1 3 3 3 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 KOO26533.1 - 0.053 12.5 0.0 0.082 11.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 KOO26533.1 - 0.1 12.5 1.4 0.32 10.9 0.1 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family C2-C2_1 PF11618.8 KOO26535.1 - 5.4e-46 156.2 0.0 6.3e-33 113.8 0.0 4.2 4 0 0 4 4 4 2 First C2 domain of RPGR-interacting protein 1 RPGR1_C PF18111.1 KOO26535.1 - 3.3e-22 79.2 0.0 7.3e-08 32.5 0.0 5.5 4 1 1 5 5 5 4 Retinitis pigmentosa G-protein regulator interacting C-terminal C2 PF00168.30 KOO26535.1 - 1.8e-09 37.8 0.0 3.2e-07 30.6 0.0 2.8 2 0 0 2 2 2 1 C2 domain Serine_rich PF08824.10 KOO26535.1 - 0.01 15.9 1.9 0.01 15.9 1.9 2.3 3 0 0 3 3 3 0 Serine rich protein interaction domain IQ PF00612.27 KOO26535.1 - 0.019 14.7 0.1 0.052 13.4 0.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif HALZ PF02183.18 KOO26535.1 - 7.5 6.9 12.0 4.6 7.5 0.1 3.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper AAA PF00004.29 KOO26536.1 - 9.3e-28 97.3 0.0 7.3e-27 94.4 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO26536.1 - 7.6e-07 28.8 0.0 7.6e-07 28.8 0.0 2.0 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 KOO26536.1 - 1.5e-05 25.0 0.0 8e-05 22.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO26536.1 - 7e-05 23.3 0.5 0.0005 20.5 0.5 2.2 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 KOO26536.1 - 0.00022 21.0 0.0 0.00038 20.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOO26536.1 - 0.001 19.3 0.1 0.048 13.9 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO26536.1 - 0.0012 19.0 0.1 0.0028 17.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KOO26536.1 - 0.0022 17.8 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 KOO26536.1 - 0.0025 17.2 0.1 0.0051 16.2 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.16 KOO26536.1 - 0.0069 15.9 0.1 0.012 15.1 0.1 1.4 1 0 0 1 1 1 1 PhoH-like protein TIP49 PF06068.13 KOO26536.1 - 0.0071 15.6 0.0 0.0097 15.1 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain Sigma54_activat PF00158.26 KOO26536.1 - 0.022 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 KOO26536.1 - 0.069 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOO26536.1 - 0.12 12.1 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOO26536.1 - 0.14 11.7 0.4 0.39 10.3 0.4 2.0 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOO26536.1 - 0.19 11.2 0.0 0.57 9.7 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 KOO26536.1 - 0.23 11.5 0.0 0.39 10.7 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE GFO_IDH_MocA PF01408.22 KOO26537.1 - 2.7e-18 66.9 0.2 5e-18 66.1 0.2 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 KOO26537.1 - 0.14 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Pyr_redox PF00070.27 KOO26537.1 - 0.14 12.7 0.2 1.6 9.4 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DsbC PF11412.8 KOO26538.1 - 7.1 6.7 5.4 10 6.2 0.5 2.8 3 0 0 3 3 3 0 Disulphide bond corrector protein DsbC DUF3638 PF12340.8 KOO26539.1 - 1.2e-30 106.5 0.0 3.8e-24 85.3 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO26539.1 - 8.7e-15 53.8 0.1 2.7e-14 52.3 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) EF-hand_6 PF13405.6 KOO26539.1 - 7.3e-08 31.7 0.0 0.019 14.8 0.0 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO26539.1 - 1.8e-06 27.0 0.0 0.011 15.3 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO26539.1 - 7.6e-06 26.3 0.0 0.22 12.0 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO26539.1 - 0.00086 19.1 0.0 1.2 9.1 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO26539.1 - 0.0031 16.9 0.0 0.03 13.8 0.0 2.4 2 0 0 2 2 2 1 EF hand Glu_cyclase_2 PF05096.12 KOO26540.1 - 1.6e-38 132.6 0.0 1.9e-38 132.3 0.0 1.0 1 0 0 1 1 1 1 Glutamine cyclotransferase Ank_2 PF12796.7 KOO26541.1 - 1.1e-28 99.6 10.1 4.1e-15 56.1 0.3 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO26541.1 - 6.5e-27 93.6 6.4 4.3e-08 33.5 0.1 6.1 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO26541.1 - 6.4e-21 74.1 17.8 1.3e-08 35.0 0.7 5.7 2 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 KOO26541.1 - 3.3e-19 68.4 14.8 0.0005 20.4 0.0 6.2 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 KOO26541.1 - 2e-17 61.5 12.5 0.0027 18.0 0.1 7.3 8 0 0 8 8 8 4 Ankyrin repeat IQ PF00612.27 KOO26542.1 - 0.00071 19.1 3.1 0.0019 17.8 3.1 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif SBDS_C PF09377.10 KOO26542.1 - 0.57 10.2 0.0 0.57 10.2 0.0 2.8 2 2 1 3 3 3 0 SBDS protein C-terminal domain C2 PF00168.30 KOO26543.1 - 7.8e-25 87.2 0.0 7e-14 52.0 0.0 2.7 2 0 0 2 2 2 2 C2 domain EF-hand_5 PF13202.6 KOO26543.1 - 2.9e-10 39.2 0.2 0.00012 21.4 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 KOO26543.1 - 8.9e-10 37.4 0.1 0.001 18.5 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO26543.1 - 2e-08 34.5 3.8 2.5e-08 34.3 0.1 3.0 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO26543.1 - 3.9e-08 32.6 0.0 0.0019 18.0 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO26543.1 - 1.2e-06 28.3 0.1 4.1e-06 26.6 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair Adaptin_binding PF10199.9 KOO26543.1 - 0.17 12.5 6.6 0.56 10.8 4.9 2.4 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 EF-hand_4 PF12763.7 KOO26543.1 - 0.17 11.8 0.3 8.9 6.3 0.0 2.6 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO26543.1 - 0.24 11.3 0.0 0.24 11.3 0.0 2.2 2 1 0 2 2 2 0 EF hand DnaJ PF00226.31 KOO26544.1 - 1.4e-13 50.7 0.0 8.3e-13 48.3 0.1 2.3 2 1 0 2 2 2 1 DnaJ domain Arm PF00514.23 KOO26545.1 - 3.9e-27 93.4 12.5 1.8e-05 24.6 0.3 5.8 5 0 0 5 5 5 5 Armadillo/beta-catenin-like repeat Dynamin_N PF00350.23 KOO26545.1 - 0.00027 21.0 0.0 0.00048 20.2 0.0 1.4 1 0 0 1 1 1 1 Dynamin family HEAT_EZ PF13513.6 KOO26545.1 - 0.0083 16.6 1.4 0.0083 16.6 1.4 5.9 3 1 1 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.6 KOO26545.1 - 0.041 14.3 32.4 0.12 12.8 8.8 4.0 2 1 1 4 4 4 0 HEAT repeats HEAT PF02985.22 KOO26545.1 - 0.076 13.3 0.0 0.076 13.3 0.0 5.3 6 0 0 6 6 6 0 HEAT repeat Dynamin_M PF01031.20 KOO26545.1 - 0.1 11.8 0.0 1.2 8.3 0.0 2.1 1 1 1 2 2 2 0 Dynamin central region Vac14_Fab1_bd PF12755.7 KOO26545.1 - 0.13 12.9 0.0 1.2e+02 3.3 0.0 3.9 3 2 1 4 4 4 0 Vacuolar 14 Fab1-binding region MMR_HSR1 PF01926.23 KOO26545.1 - 0.18 11.9 0.0 0.43 10.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Succ_CoA_lig PF13607.6 KOO26545.1 - 6.1 6.6 18.0 2.5 7.9 1.0 4.3 1 1 2 4 4 4 0 Succinyl-CoA ligase like flavodoxin domain Sel1 PF08238.12 KOO26546.1 - 6e-11 42.7 10.3 7.9e-05 23.2 0.1 4.3 5 0 0 5 5 5 2 Sel1 repeat SET PF00856.28 KOO26547.1 - 4.2e-11 43.5 0.0 1e-09 39.0 0.0 2.1 1 1 0 1 1 1 1 SET domain SAF PF08666.12 KOO26547.1 - 0.017 15.7 0.0 0.52 11.0 0.0 2.3 2 0 0 2 2 2 0 SAF domain Dpy-30 PF05186.13 KOO26547.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Dpy-30 motif LMBR1 PF04791.16 KOO26548.1 - 4.4e-46 157.9 30.5 3.1e-31 108.9 9.9 2.0 1 1 1 2 2 2 2 LMBR1-like membrane protein DUF4199 PF13858.6 KOO26548.1 - 0.02 15.3 6.5 0.02 15.3 6.5 4.3 2 2 2 4 4 4 0 Protein of unknown function (DUF4199) FAD_binding_1 PF00667.20 KOO26549.1 - 2.3e-35 122.2 0.0 3.1e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KOO26549.1 - 9.2e-27 94.0 0.1 1.6e-26 93.2 0.1 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 KOO26549.1 - 2.7e-16 60.1 0.0 5.4e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain GCV_T PF01571.21 KOO26550.1 - 0.12 11.7 0.1 0.26 10.6 0.1 1.5 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain Ribonuc_red_lgC PF02867.15 KOO26551.1 - 1.1e-187 624.7 0.0 1.4e-187 624.4 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 KOO26551.1 - 8.8e-25 86.5 0.0 2.1e-24 85.3 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 KOO26551.1 - 9e-15 55.0 0.0 2.2e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 ATP cone domain Glyco_hydro_5_C PF18564.1 KOO26556.1 - 7.3e-09 36.0 0.0 9e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain COXG PF06240.13 KOO26556.1 - 0.027 14.2 0.0 0.056 13.2 0.0 1.5 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit G (CoxG) Cellulase PF00150.18 KOO26557.1 - 4.5e-15 55.8 0.0 7.6e-14 51.8 0.0 2.7 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 KOO26557.1 - 2e-06 27.4 0.0 4.9e-06 26.1 0.0 1.5 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_35 PF01301.19 KOO26557.1 - 0.00048 19.8 0.0 0.0009 19.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 EF-hand_6 PF13405.6 KOO26557.1 - 0.016 15.1 0.3 0.051 13.5 0.3 1.9 1 1 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 KOO26557.1 - 0.13 11.9 0.3 0.3 10.7 0.3 1.7 1 0 0 1 1 1 0 EF hand Cyto_heme_lyase PF01265.17 KOO26558.1 - 6.3e-60 203.2 0.5 4.7e-59 200.4 0.5 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase CPG4 PF15481.6 KOO26558.1 - 0.06 14.0 0.8 0.12 13.0 0.8 1.4 1 0 0 1 1 1 0 Chondroitin proteoglycan 4 MFS_1 PF07690.16 KOO26559.1 - 0.00061 18.8 3.3 0.00073 18.6 3.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO26559.1 - 0.062 12.1 1.5 0.068 12.0 1.5 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter Peptidase_C2 PF00648.21 KOO26560.1 - 7.8e-78 261.5 0.0 1.2e-77 260.9 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KOO26560.1 - 2e-18 67.0 0.0 2.6e-08 34.2 0.0 3.4 2 1 1 3 3 3 3 Calpain large subunit, domain III EF-hand_6 PF13405.6 KOO26562.1 - 2.9e-22 76.7 0.2 8.2e-06 25.3 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO26562.1 - 1.9e-20 70.8 5.7 3.6e-06 26.1 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO26562.1 - 6.6e-19 68.1 0.4 5.7e-06 26.7 0.2 4.8 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO26562.1 - 3.6e-13 48.4 8.8 1.6e-05 24.2 0.3 3.9 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO26562.1 - 1.1e-12 47.6 1.5 4.3e-06 26.5 0.2 3.4 2 1 1 3 3 3 3 EF-hand domain pair Caleosin PF05042.13 KOO26562.1 - 0.024 14.6 0.1 37 4.2 0.0 3.8 2 2 2 4 4 4 0 Caleosin related protein AAA_11 PF13086.6 KOO26564.1 - 5.4e-55 187.0 0.1 3.3e-54 184.4 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO26564.1 - 7.5e-15 55.1 3.0 1.2e-12 48.0 3.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 KOO26564.1 - 3.3e-10 39.9 0.0 5.6e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO26564.1 - 3.7e-09 37.1 0.1 1.6e-08 35.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOO26564.1 - 3.8e-06 26.8 0.0 0.049 13.4 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 KOO26564.1 - 0.00018 20.9 0.0 0.26 10.5 0.0 2.3 2 1 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 KOO26564.1 - 0.0003 21.2 0.7 0.0003 21.2 0.7 2.2 2 1 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO26564.1 - 0.00044 20.5 0.0 0.0042 17.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain PIF1 PF05970.14 KOO26564.1 - 0.0007 18.9 0.0 0.32 10.1 0.0 2.2 2 0 0 2 2 2 2 PIF1-like helicase AAA PF00004.29 KOO26564.1 - 0.001 19.5 0.0 0.002 18.5 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.9 KOO26564.1 - 0.0032 16.4 0.0 0.0059 15.6 0.0 1.3 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA_33 PF13671.6 KOO26564.1 - 0.0042 17.2 0.1 0.015 15.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOO26564.1 - 0.0058 16.9 0.2 0.028 14.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 KOO26564.1 - 0.0061 16.1 0.3 0.03 13.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 KOO26564.1 - 0.0087 15.9 5.6 0.2 11.5 0.2 3.2 3 1 0 3 3 3 1 Helicase UvrD-helicase PF00580.21 KOO26564.1 - 0.013 15.1 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Herpes_ori_bp PF02399.15 KOO26564.1 - 0.013 13.6 0.0 0.018 13.1 0.0 1.1 1 0 0 1 1 1 0 Origin of replication binding protein AAA_18 PF13238.6 KOO26564.1 - 0.035 14.6 0.2 0.18 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 KOO26564.1 - 0.041 13.5 0.1 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 KOO26564.1 - 0.051 12.5 0.1 0.1 11.6 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DEAD PF00270.29 KOO26564.1 - 0.053 13.3 0.0 0.15 11.9 0.0 1.8 1 1 0 1 1 1 0 DEAD/DEAH box helicase Zot PF05707.12 KOO26564.1 - 0.055 13.1 0.0 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) IstB_IS21 PF01695.17 KOO26564.1 - 0.066 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Rad17 PF03215.15 KOO26564.1 - 0.071 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase PF06745.13 KOO26564.1 - 0.078 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 KaiC CbiA PF01656.23 KOO26564.1 - 0.11 12.5 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Prot_ATP_ID_OB PF16450.5 KOO26564.1 - 0.13 12.3 0.2 1.6 8.7 0.0 2.8 3 0 0 3 3 2 0 Proteasomal ATPase OB C-terminal domain ResIII PF04851.15 KOO26564.1 - 0.14 12.1 0.0 0.56 10.2 0.0 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 KOO26564.1 - 0.16 12.0 0.1 0.46 10.5 0.1 1.7 2 0 0 2 2 2 0 Flavivirus DEAD domain NTPase_1 PF03266.15 KOO26564.1 - 0.16 11.8 0.1 0.91 9.4 0.0 2.0 2 0 0 2 2 2 0 NTPase AAA_23 PF13476.6 KOO26564.1 - 0.17 12.4 0.0 0.43 11.1 0.0 1.5 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 KOO26564.1 - 0.2 12.1 0.0 0.37 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 KOO26564.1 - 0.21 11.3 0.0 0.69 9.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain PspA_IM30 PF04012.12 KOO26565.1 - 4e-42 144.3 31.1 6.2e-42 143.7 31.1 1.2 1 0 0 1 1 1 1 PspA/IM30 family SHE3 PF17078.5 KOO26565.1 - 0.012 15.3 9.5 0.04 13.6 3.4 2.5 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 LAGLIDADG_WhiA PF14527.6 KOO26565.1 - 0.037 14.1 0.6 0.097 12.8 0.6 1.8 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain Snapin_Pallidin PF14712.6 KOO26565.1 - 0.52 10.8 0.0 0.52 10.8 0.0 3.7 3 1 0 3 3 3 0 Snapin/Pallidin AAA_19 PF13245.6 KOO26565.1 - 0.63 10.4 4.8 4.1 7.7 3.2 2.6 1 1 0 2 2 2 0 AAA domain Fib_alpha PF08702.10 KOO26565.1 - 2.1 8.5 13.3 1 9.6 6.6 2.9 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family CENP-H PF05837.12 KOO26565.1 - 2.6 8.5 24.7 1.4 9.4 7.9 3.0 1 1 1 3 3 3 0 Centromere protein H (CENP-H) UvrD_C_2 PF13538.6 KOO26566.1 - 0.14 12.0 0.0 0.46 10.3 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain PIF1 PF05970.14 KOO26568.1 - 3.5e-13 49.5 0.0 7.4e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase SAP PF02037.27 KOO26568.1 - 1.2e-06 28.1 0.4 2.4e-06 27.2 0.4 1.5 1 0 0 1 1 1 1 SAP domain AAA_30 PF13604.6 KOO26568.1 - 1.3e-06 28.3 0.0 4.8e-06 26.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO26568.1 - 7.1e-05 23.2 0.0 0.00014 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO26568.1 - 0.00023 21.6 0.2 0.0012 19.2 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 KOO26568.1 - 0.0093 15.9 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea SH3_9 PF14604.6 KOO26570.1 - 9.3e-24 83.0 2.9 0.0004 20.2 0.0 6.6 6 0 0 6 6 6 6 Variant SH3 domain SH3_1 PF00018.28 KOO26570.1 - 1.3e-18 66.3 0.1 0.0031 17.1 0.0 6.5 6 0 0 6 6 6 5 SH3 domain SH3_2 PF07653.17 KOO26570.1 - 7.9e-18 63.9 0.1 3.5e-05 23.4 0.0 5.7 6 0 0 6 6 6 4 Variant SH3 domain AAA_12 PF13087.6 KOO26573.1 - 1e-44 152.6 0.0 1.7e-44 151.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO26573.1 - 4.1e-30 105.4 0.1 6.6e-17 62.1 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 KOO26573.1 - 1.4e-15 57.5 0.5 1.4e-15 57.5 0.5 2.7 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 KOO26573.1 - 3.7e-10 39.9 0.0 0.0081 15.9 0.0 3.4 2 1 1 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 KOO26573.1 - 6.4e-10 39.5 0.1 1.4e-09 38.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 KOO26573.1 - 2.1e-05 24.5 0.1 8.2e-05 22.5 0.1 2.0 1 1 0 1 1 1 1 Helicase AAA_16 PF13191.6 KOO26573.1 - 8e-05 23.1 5.8 0.00021 21.7 0.1 3.6 4 0 0 4 4 4 1 AAA ATPase domain UvrD_C_2 PF13538.6 KOO26573.1 - 8.5e-05 22.3 0.0 0.0003 20.6 0.0 2.0 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Dna2 PF08696.11 KOO26573.1 - 0.00089 19.1 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 DNA replication factor Dna2 MeaB PF03308.16 KOO26573.1 - 0.016 14.2 0.4 0.033 13.2 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 KOO26573.1 - 0.017 14.7 0.1 0.065 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOO26573.1 - 0.031 14.0 0.0 0.099 12.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KOO26573.1 - 0.058 13.5 0.0 0.38 10.9 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_5 PF07728.14 KOO26573.1 - 0.068 13.2 0.1 0.2 11.7 0.1 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 KOO26573.1 - 0.074 13.0 0.1 0.36 10.7 0.0 2.0 2 0 0 2 2 2 0 NTPase DUF2075 PF09848.9 KOO26573.1 - 0.088 12.0 0.1 0.7 9.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 KOO26573.1 - 0.12 12.6 0.1 0.39 10.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 KOO26573.1 - 0.18 11.4 0.2 0.57 9.8 0.1 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NB-ARC PF00931.22 KOO26573.1 - 0.2 10.8 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain UvrD_C PF13361.6 KOO26573.1 - 0.2 11.0 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 KOO26573.1 - 0.25 10.8 0.0 0.39 10.2 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 KOO26573.1 - 0.26 10.4 0.0 5.4 6.1 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase Exostosin PF03016.15 KOO26576.1 - 1.5e-30 106.5 0.1 2.2e-30 105.9 0.1 1.2 1 0 0 1 1 1 1 Exostosin family IQ PF00612.27 KOO26577.1 - 2e-11 42.6 10.2 0.00099 18.7 0.3 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif RsgA_N PF16745.5 KOO26577.1 - 0.018 14.8 0.1 8.1 6.3 0.0 3.1 3 0 0 3 3 3 0 RsgA N-terminal domain Ank_5 PF13857.6 KOO26578.1 - 2.1e-10 40.6 3.7 3.1e-05 24.2 0.5 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO26578.1 - 9.2e-09 35.8 0.1 2.7e-08 34.3 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO26578.1 - 6.9e-07 29.7 3.9 1.4e-05 25.5 0.9 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO26578.1 - 9.9e-05 22.6 4.6 0.02 15.4 0.2 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO26578.1 - 0.00053 20.2 3.3 0.54 11.0 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat DUF1664 PF07889.12 KOO26578.1 - 0.033 14.2 0.9 0.23 11.5 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4472 PF14739.6 KOO26578.1 - 0.12 13.1 17.4 0.17 12.6 6.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4472) AATF-Che1 PF13339.6 KOO26578.1 - 1.5 9.5 9.2 1.4 9.6 7.0 2.1 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor CENP-F_leu_zip PF10473.9 KOO26578.1 - 5.9 6.9 16.1 0.5 10.4 6.8 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 KOO26578.1 - 8.7 4.8 8.4 14 4.2 8.4 1.2 1 0 0 1 1 1 0 AAA domain Lipase_3 PF01764.25 KOO26579.1 - 1.6e-19 70.2 0.0 2.9e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_3 PF07859.13 KOO26579.1 - 2.4e-05 24.3 0.1 5.4e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold PLA2_B PF01735.18 KOO26579.1 - 0.00065 18.2 0.5 0.00065 18.2 0.5 1.6 2 0 0 2 2 2 1 Lysophospholipase catalytic domain Abhydrolase_1 PF00561.20 KOO26579.1 - 0.0035 17.0 0.0 0.007 16.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold EF-hand_7 PF13499.6 KOO26579.1 - 0.011 16.2 0.0 0.07 13.6 0.0 2.4 2 1 1 3 3 3 0 EF-hand domain pair Abhydrolase_6 PF12697.7 KOO26579.1 - 0.017 15.7 6.8 0.072 13.7 0.1 3.2 2 1 1 3 3 3 0 Alpha/beta hydrolase family EF-hand_6 PF13405.6 KOO26579.1 - 0.02 14.8 0.0 7.5 6.8 0.0 3.0 2 0 0 2 2 2 0 EF-hand domain Patatin PF01734.22 KOO26579.1 - 0.08 13.1 1.5 0.3 11.3 0.1 2.5 3 0 0 3 3 3 0 Patatin-like phospholipase EF-hand_1 PF00036.32 KOO26579.1 - 0.11 12.1 0.0 21 5.0 0.0 2.9 3 0 0 3 3 3 0 EF hand DUF2974 PF11187.8 KOO26579.1 - 0.11 12.0 0.0 1.4 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) AXE1 PF05448.12 KOO26579.1 - 0.12 11.0 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Esterase PF00756.20 KOO26579.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Putative esterase DUF4217 PF13959.6 KOO26580.1 - 8.3e-19 67.6 0.1 1.6e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 KOO26580.1 - 1e-17 64.5 0.0 2.9e-17 63.0 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO26580.1 - 1e-15 57.9 0.0 1.8e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AP1AR PF15745.5 KOO26580.1 - 3 7.4 11.7 4.7 6.8 11.7 1.2 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein EGF_CA PF07645.15 KOO26581.1 - 3 8.1 11.2 6.5 7.1 11.2 1.6 1 0 0 1 1 1 0 Calcium-binding EGF domain TTL PF03133.15 KOO26582.1 - 1.9e-28 99.5 0.0 4.3e-28 98.3 0.0 1.5 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO26582.1 - 0.08 12.2 0.0 3.8 6.7 0.0 2.8 2 1 1 3 3 3 0 YheC/D like ATP-grasp DUF4461 PF14688.6 KOO26583.1 - 5.9e-09 36.2 0.0 7.1e-09 35.9 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4461) LcrG PF07216.12 KOO26583.1 - 0.068 13.1 0.3 0.29 11.1 0.2 1.8 1 1 1 2 2 2 0 LcrG protein NAD_binding_1 PF00175.21 KOO26584.1 - 6.4e-08 33.2 0.0 1e-07 32.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PMSR PF01625.21 KOO26584.1 - 0.16 12.2 0.1 0.25 11.5 0.1 1.2 1 0 0 1 1 1 0 Peptide methionine sulfoxide reductase Y_phosphatase3 PF13350.6 KOO26585.1 - 4.2e-35 121.8 0.0 5.2e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 KOO26585.1 - 9e-06 25.4 0.0 1.3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KOO26585.1 - 0.00045 19.9 0.0 0.00061 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 KOO26585.1 - 0.0043 16.0 0.0 0.0049 15.9 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 KOO26585.1 - 0.025 14.4 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain BACK PF07707.15 KOO26587.1 - 1.7e-19 69.8 0.5 1.9e-17 63.2 0.1 2.2 2 0 0 2 2 2 2 BTB And C-terminal Kelch BTB PF00651.31 KOO26587.1 - 6.7e-11 42.4 0.1 1.2e-10 41.6 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ras PF00071.22 KOO26588.1 - 2.6e-56 189.7 0.1 3e-56 189.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO26588.1 - 2.3e-36 124.7 0.2 3.2e-36 124.2 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO26588.1 - 9.3e-16 57.8 0.0 1.1e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOO26588.1 - 9.9e-08 31.7 0.2 6.9e-07 29.0 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KOO26588.1 - 5e-07 29.3 0.1 6.3e-07 29.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO26588.1 - 4.8e-05 23.4 0.1 6.8e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO26588.1 - 0.00032 20.7 0.1 0.089 12.7 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 KOO26588.1 - 0.00065 19.2 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TniB PF05621.11 KOO26588.1 - 0.017 14.5 0.0 0.042 13.2 0.0 1.9 1 1 0 1 1 1 0 Bacterial TniB protein CBP_GIL PF10995.8 KOO26588.1 - 0.026 13.2 0.0 0.035 12.8 0.0 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis GIL AAA_7 PF12775.7 KOO26588.1 - 0.028 13.9 0.0 0.046 13.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 KOO26588.1 - 0.07 12.9 0.2 0.19 11.4 0.2 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 KOO26588.1 - 0.19 11.2 0.2 4.2 6.9 0.2 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_15 PF13175.6 KOO26588.1 - 0.23 11.1 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain PAPS_reduct PF01507.19 KOO26590.1 - 1.5e-27 96.7 0.0 4.3e-18 66.0 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family Glyco_hydro_3_C PF01915.22 KOO26591.1 - 2.1e-31 109.5 0.0 4.7e-31 108.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOO26591.1 - 2e-16 60.3 0.0 3.9e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOO26591.1 - 1.4e-09 37.9 0.0 3.5e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.18 KOO26591.1 - 0.017 15.4 1.4 0.083 13.2 1.4 2.3 1 1 0 1 1 1 0 Domain of unknown function DUF11 WSC PF01822.19 KOO26592.1 - 2.7e-14 53.1 12.5 5.4e-14 52.2 12.5 1.5 1 0 0 1 1 1 1 WSC domain Glyco_hydro_3 PF00933.21 KOO26592.1 - 1.8e-11 44.0 0.0 2.4e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Pkinase PF00069.25 KOO26593.1 - 1.2e-19 70.8 0.0 1.9e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CHAT PF12770.7 KOO26593.1 - 1.2e-06 28.2 0.0 3e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 CHAT domain Pkinase_Tyr PF07714.17 KOO26593.1 - 6.6e-05 22.3 0.0 0.00014 21.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO26593.1 - 0.011 15.1 0.1 0.031 13.6 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Ureide_permease PF07168.11 KOO26594.1 - 5.5 5.6 4.4 12 4.5 4.4 1.5 1 0 0 1 1 1 0 Ureide permease SR-25 PF10500.9 KOO26595.1 - 0.02 14.5 0.1 0.021 14.4 0.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein YL1 PF05764.13 KOO26595.1 - 0.093 12.8 4.6 0.1 12.7 4.6 1.1 1 0 0 1 1 1 0 YL1 nuclear protein BSP_II PF05432.11 KOO26595.1 - 0.18 11.4 1.8 0.2 11.3 1.8 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Neisseria_TspB PF05616.13 KOO26595.1 - 2.1 6.7 4.6 2.5 6.5 4.6 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein SURF4 PF02077.15 KOO26596.1 - 1.8e-12 47.4 1.5 7.2e-12 45.5 1.5 1.7 1 1 0 1 1 1 1 SURF4 family ShK PF01549.24 KOO26596.1 - 1e-07 32.4 11.4 0.00097 19.6 1.5 2.3 2 0 0 2 2 2 2 ShK domain-like Glyco_transf_10 PF00852.19 KOO26598.1 - 9.9e-06 25.4 0.0 1.5e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term DEAD PF00270.29 KOO26599.1 - 1.1e-37 129.5 0.0 3.7e-37 127.8 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO26599.1 - 4.2e-30 104.4 0.0 1.9e-29 102.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KOO26599.1 - 0.044 13.0 0.0 0.066 12.4 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Utp21 PF04192.12 KOO26601.1 - 5e-12 45.8 5.1 5e-12 45.8 5.1 2.9 2 1 1 3 3 3 2 Utp21 specific WD40 associated putative domain Spc110_C PF18520.1 KOO26601.1 - 0.094 12.3 0.1 0.22 11.2 0.1 1.6 1 0 0 1 1 1 0 Spindle pole body component 110 C-terminal domain FliE PF02049.18 KOO26601.1 - 4.7 7.4 8.1 0.37 11.0 2.0 2.3 2 1 1 3 3 3 0 Flagellar hook-basal body complex protein FliE Ribosomal_L7Ae PF01248.26 KOO26602.1 - 2.1e-18 65.8 0.1 1.4e-13 50.4 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family EF-hand_6 PF13405.6 KOO26603.1 - 9.9e-16 56.3 1.0 4.9e-06 26.1 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO26603.1 - 1.2e-14 52.6 4.2 7.2e-07 28.3 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO26603.1 - 6.1e-11 42.6 6.4 0.00034 21.0 0.0 3.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO26603.1 - 9.9e-08 31.7 2.6 2.7e-05 23.9 0.1 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO26603.1 - 1.7e-05 24.1 0.4 1.7e-05 24.1 0.4 3.3 4 0 0 4 4 4 1 EF hand KxDL PF10241.9 KOO26603.1 - 0.19 12.0 0.2 5.6 7.3 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein EF-hand_4 PF12763.7 KOO26603.1 - 1.4 8.9 3.1 14 5.7 0.1 2.8 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand PI3_PI4_kinase PF00454.27 KOO26604.1 - 5.7e-29 101.7 0.0 8.8e-26 91.2 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PH PF00169.29 KOO26604.1 - 7.8e-08 32.8 0.0 1.3e-07 32.1 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KOO26604.1 - 0.0044 17.3 0.0 0.0093 16.2 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KOO26604.1 - 0.014 15.8 0.1 0.025 15.0 0.1 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3020 PF11223.8 KOO26605.1 - 0.025 15.1 0.6 0.053 14.0 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3020) MS_channel PF00924.18 KOO26606.1 - 6e-10 39.0 0.0 8.4e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel MIP PF00230.20 KOO26607.1 - 4.3e-43 147.6 23.3 8.6e-43 146.6 23.3 1.5 1 1 0 1 1 1 1 Major intrinsic protein EF-hand_6 PF13405.6 KOO26610.1 - 5.5e-07 29.0 0.2 0.042 13.8 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO26610.1 - 2e-06 28.2 0.8 2.8e-05 24.5 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO26610.1 - 5.3e-06 26.2 0.4 0.055 13.3 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO26610.1 - 0.0019 17.6 1.3 0.28 10.8 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KOO26610.1 - 0.032 13.7 0.5 1.3 8.6 0.2 2.6 2 0 0 2 2 2 0 EF hand Caleosin PF05042.13 KOO26610.1 - 0.046 13.6 1.0 0.1 12.5 0.3 1.9 2 1 0 2 2 2 0 Caleosin related protein EF-hand_1 PF00036.32 KOO26611.1 - 2e-05 23.8 0.0 4.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO26611.1 - 7.6e-05 22.3 0.0 0.00018 21.2 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain Exo_endo_phos PF03372.23 KOO26611.1 - 0.00065 19.3 0.0 0.035 13.6 0.0 2.5 2 1 1 3 3 3 1 Endonuclease/Exonuclease/phosphatase family EF-hand_5 PF13202.6 KOO26611.1 - 0.00078 18.8 0.0 0.002 17.6 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO26611.1 - 0.0045 17.4 0.0 0.0087 16.5 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO26611.1 - 0.0055 16.5 0.2 0.029 14.2 0.1 1.7 1 1 1 2 2 2 2 EF-hand domain pair Tic110 PF16940.5 KOO26613.1 - 1.4e-34 119.6 25.1 7.8e-16 57.7 1.5 5.1 2 2 3 5 5 5 5 Chloroplast envelope transporter CLASP_N PF12348.8 KOO26614.1 - 4.3e-21 75.5 0.3 3.4e-15 56.2 0.0 2.8 3 0 0 3 3 3 2 CLASP N terminal COBRA1 PF06209.13 KOO26614.1 - 4.9e-12 45.5 0.0 3.4e-05 22.9 0.0 2.8 2 1 0 2 2 2 2 Cofactor of BRCA1 (COBRA1) DUF4042 PF13251.6 KOO26614.1 - 0.012 15.4 1.2 2.6 7.7 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) RTP1_C1 PF10363.9 KOO26614.1 - 0.014 15.6 0.2 1.1 9.4 0.0 3.6 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Death PF00531.22 KOO26614.1 - 0.22 11.7 2.7 0.39 10.9 0.1 2.9 3 0 0 3 3 3 0 Death domain HEAT PF02985.22 KOO26614.1 - 1.2 9.6 7.1 45 4.7 0.0 5.6 5 0 0 5 5 5 0 HEAT repeat ThiF PF00899.21 KOO26615.1 - 1.8e-33 115.9 0.0 6.1e-33 114.2 0.0 1.7 1 1 1 2 2 2 1 ThiF family RLAN PF14401.6 KOO26615.1 - 0.1 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 RimK-like ATPgrasp N-terminal domain Syntaxin-6_N PF09177.11 KOO26615.1 - 0.16 12.6 0.0 0.34 11.5 0.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal 2-Hacid_dh_C PF02826.19 KOO26615.1 - 0.23 10.8 0.6 0.49 9.7 0.2 1.8 2 1 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AMP-binding PF00501.28 KOO26616.1 - 2.6e-80 270.1 0.0 4.4e-80 269.3 0.0 1.3 1 1 0 1 1 1 1 AMP-binding enzyme AAA_6 PF12774.7 KOO26617.1 - 6.4e-154 511.8 0.0 9e-151 501.4 0.0 2.6 2 0 0 2 2 2 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO26617.1 - 2.8e-130 435.0 3.0 2.8e-130 435.0 3.0 2.7 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO26617.1 - 1.1e-99 333.0 0.0 2.6e-99 331.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KOO26617.1 - 1.6e-95 319.9 0.0 8.5e-95 317.5 0.0 2.2 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KOO26617.1 - 1.1e-91 305.9 0.1 4.4e-91 303.9 0.1 2.1 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 KOO26617.1 - 5.3e-69 231.4 0.4 4.9e-64 215.2 0.0 4.1 4 0 0 4 4 4 2 P-loop containing dynein motor region MT PF12777.7 KOO26617.1 - 2.6e-58 197.7 15.3 4.4e-58 196.9 15.3 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 KOO26617.1 - 1.1e-53 181.4 0.0 3.2e-53 179.9 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO26617.1 - 5e-47 158.9 0.0 1.1e-42 144.9 0.0 3.2 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 KOO26617.1 - 3.1e-25 88.7 0.0 1.8e-24 86.3 0.0 2.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KOO26617.1 - 1.2e-13 51.1 0.2 1.2e-12 47.9 0.1 3.0 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 KOO26617.1 - 2.2e-09 37.4 0.0 0.093 12.7 0.0 5.7 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA PF00004.29 KOO26617.1 - 8.7e-07 29.4 0.6 0.17 12.3 0.0 4.9 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KOO26617.1 - 3e-06 27.8 0.7 0.059 13.9 0.0 5.6 5 0 0 5 5 5 1 AAA domain AAA_16 PF13191.6 KOO26617.1 - 1.1e-05 25.9 3.2 0.11 12.8 0.1 5.8 5 1 0 5 5 4 1 AAA ATPase domain AAA_22 PF13401.6 KOO26617.1 - 1.3e-05 25.4 0.5 12 6.2 0.0 5.9 5 0 0 5 5 5 0 AAA domain AAA_29 PF13555.6 KOO26617.1 - 3.8e-05 23.3 0.3 0.038 13.7 0.1 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO26617.1 - 0.0042 17.0 0.2 1.1 9.2 0.0 3.6 3 0 0 3 3 3 1 RsgA GTPase Sigma54_activat PF00158.26 KOO26617.1 - 0.0064 16.2 0.4 5.7 6.6 0.0 3.5 4 0 0 4 4 4 1 Sigma-54 interaction domain RNA_helicase PF00910.22 KOO26617.1 - 0.0072 16.7 0.5 51 4.3 0.0 4.2 3 0 0 3 3 3 0 RNA helicase DUF815 PF05673.13 KOO26617.1 - 0.074 12.2 0.3 6.7 5.8 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 KOO26617.1 - 0.1 12.2 0.4 1.2 8.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 KOO26617.1 - 0.37 11.0 1.7 28 5.0 0.1 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 KOO26617.1 - 0.66 10.1 4.2 30 4.8 0.0 4.4 5 0 0 5 5 5 0 AAA domain DUF3226 PF11536.8 KOO26617.1 - 0.75 9.4 4.8 0.35 10.5 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3226) Sec34 PF04136.15 KOO26617.1 - 1.4 8.8 7.6 3.6 7.4 0.6 4.5 4 0 0 4 4 3 0 Sec34-like family CtIP_N PF10482.9 KOO26617.1 - 2 8.5 8.4 0.13 12.3 1.0 2.9 2 0 0 2 2 1 0 Tumour-suppressor protein CtIP N-terminal domain DUF374 PF04028.13 KOO26618.1 - 0.039 13.5 0.1 0.88 9.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF374) Ion_trans PF00520.31 KOO26619.1 - 0.00024 20.4 0.0 0.00034 19.9 0.0 1.1 1 0 0 1 1 1 1 Ion transport protein zf-C2H2 PF00096.26 KOO26620.1 - 9e-24 82.6 45.9 4.8e-05 23.6 1.9 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO26620.1 - 9.6e-21 73.2 42.0 1.1e-06 28.8 1.9 7.3 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO26620.1 - 1.3e-15 56.8 38.4 0.0058 17.4 1.3 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger zf-RING_2 PF13639.6 KOO26620.1 - 0.0052 17.1 0.8 0.0052 17.1 0.8 4.5 3 2 2 5 5 3 1 Ring finger domain zf-C2H2_8 PF15909.5 KOO26620.1 - 0.0086 16.4 12.1 0.31 11.4 4.6 2.7 1 1 1 2 2 2 2 C2H2-type zinc ribbon FANCL_C PF11793.8 KOO26620.1 - 0.024 14.8 26.5 0.031 14.4 0.3 7.0 2 1 4 6 6 6 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 KOO26620.1 - 0.12 12.0 0.0 0.12 12.0 0.0 4.1 6 0 0 6 6 6 0 Zinc-ribbon, C4HC2 type zf-C2H2_aberr PF17017.5 KOO26620.1 - 0.24 11.5 15.2 0.62 10.2 0.8 4.9 3 1 2 5 5 5 0 Aberrant zinc-finger zf-C2H2_6 PF13912.6 KOO26620.1 - 0.84 9.7 39.4 0.38 10.8 0.5 6.1 6 0 0 6 6 6 0 C2H2-type zinc finger CHORD PF04968.12 KOO26620.1 - 1.4 9.7 31.6 1.8 9.3 0.6 5.6 3 1 3 6 6 5 0 CHORD zf-LYAR PF08790.11 KOO26620.1 - 1.8 8.6 9.8 29 4.7 0.1 5.1 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger Fer2 PF00111.27 KOO26620.1 - 9.3 6.3 15.2 43 4.1 0.1 5.2 5 0 0 5 5 5 0 2Fe-2S iron-sulfur cluster binding domain Ion_trans PF00520.31 KOO26621.1 - 2e-20 73.1 2.6 3.4e-20 72.3 2.6 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO26621.1 - 5.8e-12 45.4 0.3 5.8e-12 45.4 0.3 1.9 2 0 0 2 2 2 1 Ion channel EF-hand_6 PF13405.6 KOO26621.1 - 8.7e-06 25.3 0.2 0.11 12.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO26621.1 - 1.6e-05 24.1 0.2 0.0071 15.8 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO26621.1 - 5e-05 22.6 1.5 0.00045 19.6 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO26621.1 - 0.00019 21.8 0.6 0.002 18.6 0.6 2.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO26621.1 - 0.09 12.6 0.1 0.53 10.2 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair Aminotran_1_2 PF00155.21 KOO26622.1 - 1.3e-42 146.3 0.0 1.5e-42 146.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KOO26622.1 - 2.3e-06 26.4 0.0 3.1e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KOO26622.1 - 0.042 12.8 0.0 0.074 12.0 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Ank_2 PF12796.7 KOO26623.1 - 1e-13 51.7 0.0 2.5e-07 31.2 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO26623.1 - 6.5e-13 47.6 0.0 0.012 16.0 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KOO26623.1 - 9.7e-10 38.8 0.0 0.00022 21.7 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO26623.1 - 5.9e-06 26.5 0.1 0.0006 20.1 0.0 2.5 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO26623.1 - 0.00012 22.4 0.5 0.14 12.6 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Abhydrolase_6 PF12697.7 KOO26624.1 - 0.032 14.8 1.0 0.039 14.5 1.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO26624.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 UBA PF00627.31 KOO26625.1 - 0.00078 19.3 1.6 0.0021 17.9 1.6 1.8 1 0 0 1 1 1 1 UBA/TS-N domain RAP80_UIM PF18282.1 KOO26625.1 - 0.035 13.9 0.1 0.076 12.8 0.1 1.5 1 0 0 1 1 1 0 RAP80 N-terminal ubiquitin interaction motif Glucodextran_N PF09137.11 KOO26625.1 - 0.14 11.7 0.9 0.2 11.2 0.2 1.6 2 0 0 2 2 2 0 Glucodextranase, domain N Glyoxalase_3 PF13468.6 KOO26626.1 - 6.7e-29 101.2 0.1 8.9e-29 100.8 0.1 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Peptidase_M10 PF00413.24 KOO26627.1 - 4.9e-23 81.7 0.0 6.8e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 KOO26627.1 - 7.4e-09 35.7 0.0 1.9e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PG_binding_3 PF09374.10 KOO26627.1 - 5.9e-08 32.9 0.3 0.0013 18.9 0.0 2.5 1 1 1 2 2 2 2 Predicted Peptidoglycan domain Metallopep PF12044.8 KOO26627.1 - 0.042 12.5 0.0 0.058 12.0 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family DUF4953 PF16313.5 KOO26627.1 - 0.11 11.7 0.1 0.11 11.7 0.1 1.5 2 0 0 2 2 2 0 Met-zincin Med3 PF11593.8 KOO26627.1 - 3 6.9 5.3 4.2 6.5 5.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal cNMP_binding PF00027.29 KOO26628.1 - 2.8e-14 52.9 0.1 5.8e-14 51.9 0.1 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain C2 PF00168.30 KOO26629.1 - 5.6e-09 36.2 0.0 9e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 C2 domain PX PF00787.24 KOO26629.1 - 0.00042 20.3 0.1 0.00077 19.4 0.1 1.4 1 0 0 1 1 1 1 PX domain UTRA PF07702.13 KOO26629.1 - 0.085 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 UTRA domain ACBP PF00887.19 KOO26629.1 - 0.21 11.8 0.2 0.38 11.0 0.2 1.4 1 0 0 1 1 1 0 Acyl CoA binding protein Gly-zipper_Omp PF13488.6 KOO26629.1 - 0.42 10.6 17.3 1.2 9.2 17.3 1.8 1 0 0 1 1 1 0 Glycine zipper Methyltransf_22 PF13383.6 KOO26630.1 - 2.9e-15 56.5 0.1 3.7e-15 56.2 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 KOO26630.1 - 0.0003 20.9 0.0 0.00033 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain PABP PF00658.18 KOO26631.1 - 2.3e-07 30.9 0.0 6.2e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain OTU PF02338.19 KOO26631.1 - 0.0016 18.9 0.0 0.004 17.6 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease HAT_KAT11 PF08214.11 KOO26632.1 - 2.2e-20 73.2 0.0 4.4e-20 72.3 0.0 1.4 1 1 0 1 1 1 1 Histone acetylation protein VIT1 PF01988.19 KOO26633.1 - 8.9e-19 68.2 22.0 2e-11 44.2 4.7 2.7 2 1 1 3 3 3 2 VIT family TPT PF03151.16 KOO26633.1 - 3.8e-13 49.4 2.5 5e-13 49.0 2.5 1.3 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 KOO26633.1 - 0.025 13.8 0.4 0.025 13.8 0.4 2.1 3 0 0 3 3 3 0 UAA transporter family Kinesin PF00225.23 KOO26634.1 - 8.6e-65 218.8 0.0 1.7e-43 148.8 0.0 2.2 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KOO26634.1 - 8.6e-15 55.0 0.0 1.4e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding SAP PF02037.27 KOO26634.1 - 7e-05 22.5 1.0 0.00013 21.7 0.0 2.0 2 0 0 2 2 2 1 SAP domain Nop25 PF09805.9 KOO26634.1 - 3 8.3 7.2 7.4 7.0 7.2 1.6 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) XRCC4 PF06632.12 KOO26636.1 - 5.1e-07 28.9 2.9 8.1e-06 24.9 2.9 2.0 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Csm1_N PF18504.1 KOO26636.1 - 0.027 14.8 2.3 0.066 13.6 0.5 2.1 2 0 0 2 2 2 0 Csm1 N-terminal domain TMF_TATA_bd PF12325.8 KOO26636.1 - 0.048 13.9 0.6 0.085 13.1 0.6 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.11 KOO26636.1 - 0.14 12.3 5.9 0.35 11.1 0.5 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Sporozoite_P67 PF05642.11 KOO26636.1 - 0.18 9.8 2.1 0.26 9.3 2.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen APG6_N PF17675.1 KOO26636.1 - 0.26 11.8 7.3 0.13 12.8 4.8 1.7 1 1 1 2 2 2 0 Apg6 coiled-coil region Spc24 PF08286.11 KOO26636.1 - 0.71 10.1 3.7 2.4 8.4 3.7 1.9 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 SH3_2 PF07653.17 KOO26638.1 - 1.5e-12 47.0 0.0 3.2e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOO26638.1 - 2.2e-10 40.2 0.0 4.6e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KOO26638.1 - 1.5e-08 34.1 0.1 3.2e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 SH3 domain MORN PF02493.20 KOO26638.1 - 0.62 10.1 7.9 0.74 9.8 0.4 4.1 3 0 0 3 3 3 0 MORN repeat CBM_20 PF00686.19 KOO26639.1 - 1.7e-11 43.9 0.0 2.1e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Starch binding domain AMP-binding PF00501.28 KOO26640.1 - 3.8e-57 193.8 0.2 5.6e-39 133.9 0.0 2.3 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 KOO26640.1 - 0.17 12.9 0.1 0.47 11.5 0.1 1.9 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain PhyH PF05721.13 KOO26641.1 - 6e-12 46.3 0.0 7.9e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) RRM_1 PF00076.22 KOO26641.1 - 0.00028 20.7 0.0 0.011 15.5 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 2OG-FeII_Oxy_5 PF13759.6 KOO26641.1 - 0.21 12.0 0.0 0.45 10.9 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Kinesin PF00225.23 KOO26642.1 - 2.2e-111 372.0 0.1 9.8e-103 343.6 0.0 2.2 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KOO26642.1 - 6.7e-27 94.3 0.1 1.3e-25 90.0 0.0 2.6 2 1 1 3 3 3 1 Microtubule binding DUF2408 PF10303.9 KOO26642.1 - 0.094 13.3 1.0 13 6.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) Cnn_1N PF07989.11 KOO26642.1 - 0.096 12.9 0.4 0.28 11.4 0.4 1.8 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF5427 PF10310.9 KOO26642.1 - 0.12 11.3 2.0 0.26 10.2 2.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Ank_3 PF13606.6 KOO26643.1 - 3.1e-14 51.7 2.2 0.00031 21.0 0.0 5.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 KOO26643.1 - 9.5e-12 44.9 3.6 0.00011 22.4 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO26643.1 - 3.3e-11 43.1 12.1 0.00027 21.2 0.0 5.3 5 0 0 5 5 5 2 Ankyrin repeat Ank_2 PF12796.7 KOO26643.1 - 5.6e-11 42.9 0.1 0.012 16.2 0.0 4.7 4 1 0 5 5 5 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO26643.1 - 5.4e-06 26.9 0.2 0.098 13.3 0.0 4.8 4 0 0 4 4 4 1 Ankyrin repeats (many copies) CBP_CCPA PF17040.5 KOO26643.1 - 0.051 14.2 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 Cellulose-complementing protein A DMA PF03474.14 KOO26643.1 - 0.59 9.8 0.0 0.59 9.8 0.0 2.1 3 0 0 3 3 3 0 DMRTA motif UBA_2 PF08587.11 KOO26644.1 - 0.056 13.6 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) Peptidase_S66 PF02016.15 KOO26644.1 - 0.072 13.2 0.3 0.072 13.2 0.3 2.5 2 1 0 2 2 2 0 LD-carboxypeptidase N-terminal domain Ly49 PF08391.10 KOO26644.1 - 0.34 11.3 0.2 0.34 11.3 0.2 2.6 2 1 0 3 3 3 0 Ly49-like protein, N-terminal region TFIIA PF03153.13 KOO26644.1 - 6.6 6.6 14.4 7.9 6.4 14.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAN_1 PF00024.26 KOO26645.1 - 0.048 13.6 0.7 0.1 12.6 0.6 1.7 2 0 0 2 2 2 0 PAN domain PAN_2 PF08276.11 KOO26645.1 - 0.063 13.4 2.6 0.11 12.7 1.6 2.0 2 0 0 2 2 2 0 PAN-like domain RRM_1 PF00076.22 KOO26647.1 - 9.2e-32 108.7 0.6 2.1e-16 59.5 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOO26647.1 - 5.2e-08 32.5 0.0 0.006 16.2 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO26647.1 - 2.6e-06 27.2 0.0 0.092 12.6 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KOO26647.1 - 2.8e-06 27.2 0.1 0.093 12.7 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KOO26647.1 - 4.3e-05 23.5 0.3 0.038 14.0 0.1 2.2 2 0 0 2 2 2 2 RNA binding motif RRM_7 PF16367.5 KOO26647.1 - 0.00077 19.5 0.0 0.82 9.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif PHM7_cyt PF14703.6 KOO26647.1 - 0.0042 17.4 0.6 5.3 7.2 0.0 3.1 2 1 1 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter Limkain-b1 PF11608.8 KOO26647.1 - 0.0081 16.2 0.1 1.3 9.2 0.0 2.3 2 0 0 2 2 2 1 Limkain b1 RNA_bind PF08675.11 KOO26647.1 - 0.011 15.7 0.0 0.097 12.7 0.0 2.0 2 0 0 2 2 2 0 RNA binding domain DUF1866 PF08952.11 KOO26647.1 - 0.025 14.4 0.0 0.67 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) RB_A PF01858.17 KOO26648.1 - 1.6e-47 161.9 0.0 3.5e-47 160.8 0.0 1.6 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 KOO26648.1 - 8.1e-37 126.2 0.5 1.4e-36 125.5 0.5 1.4 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain ApoLp-III PF07464.11 KOO26649.1 - 0.038 14.1 16.0 0.15 12.1 1.2 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) LapD_MoxY_N PF16448.5 KOO26649.1 - 1 9.3 5.4 4.4 7.2 0.6 2.4 2 0 0 2 2 2 0 LapD/MoxY periplasmic domain DUF842 PF05811.13 KOO26649.1 - 4.9 6.9 9.4 1.7 8.4 1.6 3.1 1 1 2 3 3 3 0 Eukaryotic protein of unknown function (DUF842) TPR_12 PF13424.6 KOO26650.1 - 1.5e-28 98.9 17.8 2.7e-10 40.4 2.1 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO26650.1 - 5.5e-20 70.6 22.2 3.3e-07 30.0 0.4 5.3 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 KOO26650.1 - 1.6e-05 24.7 17.5 0.055 13.6 2.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26650.1 - 0.00012 21.8 13.4 0.081 12.8 1.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO26650.1 - 0.00049 20.3 6.2 0.061 13.6 2.4 3.9 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KOO26650.1 - 0.0011 18.8 13.2 2.1 8.6 0.2 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26650.1 - 0.0044 17.1 8.5 0.1 12.9 0.4 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat Flu_M1_C PF08289.11 KOO26650.1 - 0.038 14.2 0.8 0.24 11.6 0.1 2.6 3 0 0 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain TPR_19 PF14559.6 KOO26650.1 - 0.36 11.4 11.2 2.4 8.7 0.2 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 KOO26650.1 - 1.5 9.0 11.0 2.1 8.5 0.1 4.0 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 KOO26650.1 - 6.9 7.4 30.5 0.5 11.1 1.4 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 KOO26651.1 - 2.3e-19 67.4 3.4 1.4e-05 24.3 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO26651.1 - 1.8e-18 64.8 2.8 4.3e-05 23.1 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO26651.1 - 3.8e-14 52.9 3.4 0.01 16.2 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO26651.1 - 9.3e-13 47.0 1.6 0.0028 17.1 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO26651.1 - 1.3e-10 41.0 4.3 0.0013 18.5 0.1 3.8 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO26651.1 - 0.0044 17.3 0.9 1.2 9.4 0.0 3.6 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO26651.1 - 0.11 12.8 0.0 23 5.4 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain LRR_4 PF12799.7 KOO26652.1 - 8.1e-13 48.3 3.5 3.9e-06 27.1 0.1 4.1 3 2 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO26652.1 - 3.3e-10 39.8 0.3 1.1e-05 25.0 0.1 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KOO26652.1 - 2.6e-08 33.5 3.9 9.4e-06 25.3 0.3 4.2 4 1 1 5 5 5 1 Leucine rich repeat LRR_6 PF13516.6 KOO26652.1 - 0.0013 18.6 4.1 53 4.2 0.0 5.3 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 KOO26652.1 - 0.013 15.9 2.1 51 5.0 0.0 5.1 4 1 0 4 4 4 0 Leucine Rich Repeat F-box-like PF12937.7 KOO26653.1 - 0.052 13.5 0.4 0.15 12.0 0.2 1.8 2 0 0 2 2 2 0 F-box-like PPR_3 PF13812.6 KOO26654.1 - 0.0029 17.6 0.0 0.12 12.4 0.0 2.4 1 1 1 2 2 2 2 Pentatricopeptide repeat domain Nterm_IS4 PF13006.7 KOO26654.1 - 0.071 13.3 0.8 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 Insertion element 4 transposase N-terminal PPR_2 PF13041.6 KOO26654.1 - 0.14 12.4 0.0 17 5.7 0.0 2.4 2 0 0 2 2 2 0 PPR repeat family SRP72 PF08492.12 KOO26655.1 - 0.051 14.0 0.6 0.051 14.0 0.6 1.7 2 0 0 2 2 2 0 SRP72 RNA-binding domain Arm PF00514.23 KOO26656.1 - 0.035 14.2 0.8 11 6.2 0.0 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat STI1 PF17830.1 KOO26659.1 - 3.4e-06 26.9 5.7 0.0023 17.8 1.7 2.3 1 1 0 2 2 2 2 STI1 domain GerD PF17898.1 KOO26659.1 - 0.064 13.2 2.1 0.18 11.8 2.1 1.7 1 1 0 1 1 1 0 Spore germination GerD central core domain MT-A70 PF05063.14 KOO26660.1 - 5.4e-46 156.6 0.0 8e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 MT-A70 Methyltransf_21 PF05050.12 KOO26660.1 - 3.3e-05 24.0 0.0 0.00057 20.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_21 PF05050.12 KOO26662.1 - 2.8e-06 27.5 0.0 6.7e-06 26.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase FkbM domain Pollen_allerg_1 PF01357.21 KOO26662.1 - 0.025 14.6 0.0 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 Pollen allergen EF-hand_6 PF13405.6 KOO26664.1 - 2.8e-46 151.5 8.9 7.2e-06 25.5 0.2 9.3 8 1 1 9 9 9 9 EF-hand domain EF-hand_1 PF00036.32 KOO26664.1 - 9.7e-43 140.6 6.3 5.7e-06 25.5 0.2 9.2 8 1 1 9 9 9 9 EF hand EF-hand_7 PF13499.6 KOO26664.1 - 3.3e-40 136.4 3.1 6.5e-08 32.9 0.0 6.0 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO26664.1 - 2.7e-33 112.0 9.4 4.8e-05 22.6 0.2 8.8 8 1 1 9 9 9 6 EF hand EF-hand_8 PF13833.6 KOO26664.1 - 4.6e-23 80.8 9.6 7.6e-06 25.7 0.4 8.6 4 3 5 9 9 9 7 EF-hand domain pair EF-hand_9 PF14658.6 KOO26664.1 - 4.7e-10 39.6 0.0 1.7 9.0 0.0 5.5 5 1 0 5 5 5 3 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO26664.1 - 4.6e-08 33.4 0.1 2.6 8.4 0.0 5.5 4 3 2 6 6 6 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO26664.1 - 6.6e-05 23.2 0.2 35 4.8 0.0 5.6 6 1 0 6 6 6 0 EF-hand domain Dockerin_1 PF00404.18 KOO26664.1 - 7.3e-05 22.9 0.2 3.6 7.9 0.0 5.1 6 0 0 6 6 6 1 Dockerin type I domain Caleosin PF05042.13 KOO26664.1 - 0.00032 20.7 0.8 16 5.3 0.1 5.5 3 3 2 6 6 6 0 Caleosin related protein TerB PF05099.13 KOO26664.1 - 0.0029 17.6 0.0 14 5.7 0.0 4.1 4 0 0 4 4 4 1 Tellurite resistance protein TerB SAP PF02037.27 KOO26664.1 - 0.024 14.4 1.9 8.2 6.3 0.1 2.9 3 0 0 3 3 3 0 SAP domain DUF2624 PF11116.8 KOO26664.1 - 0.071 14.0 0.0 25 5.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2624) TPMT PF05724.11 KOO26665.1 - 2e-34 119.2 0.0 2.7e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 KOO26665.1 - 9.7e-11 42.2 0.0 1.8e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO26665.1 - 7.6e-10 39.3 0.0 1.2e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO26665.1 - 2.5e-08 33.9 0.0 3.8e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO26665.1 - 1.1e-07 31.8 0.0 1.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO26665.1 - 2.9e-07 31.1 0.0 4.9e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO26665.1 - 0.024 14.1 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF594 PF04578.13 KOO26665.1 - 0.18 11.4 0.3 0.72 9.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF594 TAF4 PF05236.14 KOO26666.1 - 1.4 8.6 32.1 2.5e+02 1.2 32.1 2.1 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family 2OG-FeII_Oxy_3 PF13640.6 KOO26667.1 - 1e-13 51.9 0.0 1.8e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO26667.1 - 1e-05 26.1 0.0 1.9e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TLC PF03219.14 KOO26667.1 - 0.0022 16.8 4.4 0.0022 16.8 4.4 2.5 2 1 0 2 2 2 2 TLC ATP/ADP transporter DctQ PF04290.12 KOO26667.1 - 7.5 6.5 16.2 1.1 9.2 6.0 2.8 1 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component JmjC PF02373.22 KOO26669.1 - 1.2e-31 109.5 0.0 1.9e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 KOO26669.1 - 1.1e-11 44.5 0.1 2e-11 43.7 0.1 1.4 1 0 0 1 1 1 1 jmjN domain Myb_DNA-binding PF00249.31 KOO26672.1 - 3.1e-30 104.1 2.3 1.5e-14 53.9 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO26672.1 - 1e-20 73.7 0.1 1.5e-11 44.3 0.0 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain EF-hand_7 PF13499.6 KOO26672.1 - 5.3e-13 49.2 0.2 1.6e-12 47.7 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO26672.1 - 1.8e-11 42.7 0.7 0.0002 20.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO26672.1 - 2.4e-11 43.3 1.5 1.6e-07 31.1 0.4 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO26672.1 - 1.4e-08 34.0 0.2 9.5e-05 22.0 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO26672.1 - 3.6e-08 32.5 2.3 0.00073 18.9 0.0 3.0 3 0 0 3 3 3 2 EF hand Myb_DNA-bind_7 PF15963.5 KOO26672.1 - 0.0059 16.5 0.0 0.035 14.0 0.0 2.1 2 0 0 2 2 2 1 Myb DNA-binding like SLIDE PF09111.10 KOO26672.1 - 0.026 14.5 0.0 5.9 7.0 0.0 2.5 2 1 1 3 3 3 0 SLIDE Adenine_glyco PF03352.13 KOO26672.1 - 0.2 11.4 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Methyladenine glycosylase LDcluster4 PF18306.1 KOO26672.1 - 0.28 10.8 4.7 0.49 10.0 4.7 1.4 1 0 0 1 1 1 0 SLOG cluster4 family EF-hand_1 PF00036.32 KOO26674.1 - 3.7e-37 123.1 17.9 5e-06 25.7 0.1 6.2 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO26674.1 - 6e-34 113.1 17.7 3.4e-06 26.6 0.1 6.3 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.6 KOO26674.1 - 1.7e-33 114.9 30.6 5.2e-11 42.8 1.1 4.1 2 1 3 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO26674.1 - 6.3e-27 91.8 17.7 0.00021 20.6 0.1 6.3 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.6 KOO26674.1 - 1.1e-24 86.0 19.2 5.4e-07 29.4 1.1 6.1 4 2 2 6 6 6 6 EF-hand domain pair Caleosin PF05042.13 KOO26674.1 - 0.0009 19.2 3.2 7.8 6.4 0.0 4.5 3 3 2 5 5 5 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO26674.1 - 0.0037 17.6 3.3 30 5.0 0.0 4.1 2 2 1 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO26674.1 - 0.0071 16.6 0.3 9.3 6.7 0.0 4.1 4 1 1 5 5 5 1 EF-hand domain EF-hand_4 PF12763.7 KOO26674.1 - 0.027 14.4 9.6 0.52 10.3 0.1 4.6 4 2 2 6 6 6 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO26674.1 - 1.2 9.1 6.1 7.2 6.6 0.2 4.1 5 0 0 5 5 5 0 EF hand HlyU PF10115.9 KOO26675.1 - 0.008 16.2 0.1 0.22 11.6 0.0 2.1 2 0 0 2 2 2 2 Transcriptional activator HlyU Pro_isomerase PF00160.21 KOO26676.1 - 8e-37 126.9 0.1 9.7e-37 126.7 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Serine_protease PF18405.1 KOO26677.1 - 0.1 11.7 1.6 0.68 9.0 1.5 1.9 1 1 1 2 2 2 0 Gammaproteobacterial serine protease OEP PF02321.18 KOO26678.1 - 0.00086 19.2 6.8 0.00086 19.2 6.8 3.3 3 1 0 3 3 3 1 Outer membrane efflux protein Poty_coat PF00767.18 KOO26678.1 - 0.098 12.2 1.6 0.63 9.6 0.5 2.3 1 1 1 2 2 2 0 Potyvirus coat protein Cob_adeno_trans PF01923.18 KOO26678.1 - 0.41 10.8 10.1 2.6 8.1 1.4 2.4 2 0 0 2 2 2 0 Cobalamin adenosyltransferase DUF641 PF04859.12 KOO26678.1 - 0.9 9.9 16.3 0.37 11.1 3.3 2.7 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) MscS_porin PF12795.7 KOO26678.1 - 1.4 8.4 38.5 0.12 11.9 16.7 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Dynamitin PF04912.14 KOO26678.1 - 2.1 7.6 19.3 0.48 9.7 3.9 2.1 2 0 0 2 2 2 0 Dynamitin HopJ PF08888.11 KOO26679.1 - 4.5e-36 123.4 0.0 5.2e-36 123.2 0.0 1.0 1 0 0 1 1 1 1 HopJ type III effector protein Metallophos PF00149.28 KOO26680.1 - 4.6e-15 56.7 0.0 1.5e-14 55.0 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PhoD PF09423.10 KOO26680.1 - 0.0029 16.7 0.9 0.065 12.2 0.9 2.6 1 1 0 1 1 1 1 PhoD-like phosphatase Metallophos_2 PF12850.7 KOO26680.1 - 0.0067 16.6 0.1 0.34 11.1 0.0 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain TPR_2 PF07719.17 KOO26682.1 - 7.5e-05 22.5 2.1 0.15 12.3 0.1 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26682.1 - 0.00054 20.4 1.1 0.00054 20.4 1.1 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26682.1 - 0.0034 17.2 0.0 1.5 8.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_20 PF14561.6 KOO26682.1 - 0.0056 17.0 0.9 0.0056 17.0 0.9 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO26682.1 - 0.03 15.2 2.8 0.03 15.2 2.8 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26682.1 - 0.048 14.3 0.3 0.048 14.3 0.3 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat Peptidase_C1 PF00112.23 KOO26683.1 - 4.5e-13 49.8 0.0 3.2e-10 40.5 0.0 3.0 1 1 0 1 1 1 1 Papain family cysteine protease TANGO2 PF05742.12 KOO26684.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Transport and Golgi organisation 2 Glycos_transf_2 PF00535.26 KOO26685.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.5 1 1 0 1 1 1 0 Glycosyl transferase family 2 Glyco_transf_64 PF09258.10 KOO26685.1 - 0.017 14.4 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 64 domain Chloroa_b-bind PF00504.21 KOO26686.1 - 5.4e-31 108.3 0.1 7.2e-31 107.9 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DUF3110 PF11360.8 KOO26687.1 - 6.8e-19 67.9 0.9 1.9e-12 47.2 0.4 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3110) PUB PF09409.10 KOO26688.1 - 2e-13 50.1 0.0 2.7e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 PUB domain LRR_6 PF13516.6 KOO26689.1 - 6.4e-23 78.8 8.1 0.00043 20.1 0.1 7.3 6 1 0 6 6 6 4 Leucine Rich repeat SpoU_sub_bind PF08032.12 KOO26689.1 - 0.00074 19.7 0.1 2.1 8.7 0.0 2.8 2 0 0 2 2 2 2 RNA 2'-O ribose methyltransferase substrate binding LRR_4 PF12799.7 KOO26689.1 - 0.0012 19.2 3.2 22 5.6 0.1 4.7 3 2 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO26689.1 - 0.014 15.9 0.0 44 5.2 0.0 5.0 6 0 0 6 6 6 0 Leucine Rich Repeat CbiG_N PF11760.8 KOO26689.1 - 0.072 13.1 6.4 34 4.5 0.0 4.2 4 0 0 4 4 4 0 Cobalamin synthesis G N-terminal RHH_7 PF16777.5 KOO26689.1 - 0.074 13.5 0.0 1.6 9.2 0.0 2.4 2 0 0 2 2 2 0 Transcriptional regulator, RHH-like, CopG Arm-DNA-bind_1 PF09003.10 KOO26689.1 - 0.1 12.7 8.3 0.65 10.2 0.0 4.1 4 1 1 5 5 5 0 Bacteriophage lambda integrase, Arm DNA-binding domain LRR_8 PF13855.6 KOO26689.1 - 0.32 10.8 2.7 58 3.5 0.0 4.5 4 1 1 5 5 5 0 Leucine rich repeat HOASN PF14515.6 KOO26689.1 - 2.7 8.4 8.3 16 5.9 0.4 4.5 1 1 3 4 4 4 0 Haem-oxygenase-associated N-terminal helices Cys_Met_Meta_PP PF01053.20 KOO26691.1 - 3.5e-62 210.1 0.0 1.6e-46 158.6 0.0 2.5 2 1 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme TetR PF13972.6 KOO26692.1 - 0.003 17.3 0.1 0.0047 16.6 0.1 1.3 1 0 0 1 1 1 1 Bacterial transcriptional repressor WD40 PF00400.32 KOO26693.1 - 4.8e-21 74.7 17.0 2.2e-05 25.1 0.1 7.7 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO26693.1 - 0.022 15.0 0.1 9.5 6.6 0.0 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOO26693.1 - 0.26 10.6 0.0 0.45 9.8 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain EF-hand_1 PF00036.32 KOO26694.1 - 9.3e-09 34.2 0.9 4.5e-05 22.7 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO26694.1 - 3.5e-08 33.2 1.1 0.06 13.2 0.2 4.2 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO26694.1 - 9e-08 31.5 0.1 5.8e-05 22.7 0.0 3.7 5 0 0 5 5 5 1 EF-hand domain EF-hand_7 PF13499.6 KOO26694.1 - 6.7e-07 29.7 0.0 8.7e-05 22.9 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO26694.1 - 5.6e-06 25.6 0.2 0.0006 19.2 0.1 2.5 2 0 0 2 2 2 1 EF hand PMBR PF09373.10 KOO26694.1 - 0.17 12.1 0.0 23 5.4 0.0 2.8 3 0 0 3 3 3 0 Pseudomurein-binding repeat Fez1 PF06818.15 KOO26695.1 - 0.014 15.9 10.8 0.021 15.3 10.8 1.3 1 0 0 1 1 1 0 Fez1 AAA_13 PF13166.6 KOO26695.1 - 0.067 11.8 7.1 0.083 11.5 7.1 1.1 1 0 0 1 1 1 0 AAA domain DUF3450 PF11932.8 KOO26695.1 - 0.075 12.3 14.6 0.14 11.5 14.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ATG16 PF08614.11 KOO26695.1 - 0.27 11.4 21.0 3.5 7.8 10.8 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 KOO26695.1 - 0.54 7.7 20.5 0.68 7.4 20.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Stathmin PF00836.19 KOO26695.1 - 0.61 10.1 16.4 0.61 10.1 15.2 1.5 1 1 0 1 1 1 0 Stathmin family YabA PF06156.13 KOO26695.1 - 2.1 9.0 5.6 3 8.5 3.5 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Exonuc_VII_L PF02601.15 KOO26695.1 - 3.2 7.3 10.4 4.2 6.8 10.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit YlqD PF11068.8 KOO26695.1 - 7.4 7.0 9.0 15 6.0 9.0 1.5 1 1 0 1 1 1 0 YlqD protein DnaJ PF00226.31 KOO26697.1 - 4.6e-19 68.3 0.2 7.6e-19 67.6 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain UIM PF02809.20 KOO26697.1 - 0.21 11.6 10.3 0.26 11.3 0.5 3.3 2 1 0 2 2 2 0 Ubiquitin interaction motif Pentapeptide_4 PF13599.6 KOO26698.1 - 2.6e-31 107.6 0.0 0.00011 22.3 0.1 11.2 6 3 6 13 13 13 9 Pentapeptide repeats (9 copies) EF-hand_1 PF00036.32 KOO26698.1 - 2.4e-10 39.2 0.3 0.00031 20.1 0.0 3.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO26698.1 - 5.2e-09 35.3 0.3 4.7e-05 23.0 0.0 3.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO26698.1 - 3e-07 29.6 0.7 0.0073 15.8 0.1 3.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO26698.1 - 4e-07 30.4 1.8 8.7e-07 29.3 0.4 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO26698.1 - 1.5e-05 24.7 0.1 0.0016 18.3 0.0 4.0 2 0 0 2 2 2 1 EF-hand domain pair Ntox33 PF15533.6 KOO26698.1 - 5.6e-05 23.5 0.8 69 4.0 0.0 9.6 11 1 0 11 11 11 0 Bacterial toxin 33 Ribosomal_L13e PF01294.18 KOO26698.1 - 6.6e-05 22.8 28.1 0.054 13.4 0.1 13.1 12 4 5 17 17 17 1 Ribosomal protein L13e XK-related PF09815.9 KOO26698.1 - 8.7e-05 21.7 9.3 0.00038 19.6 9.3 1.9 1 1 0 1 1 1 1 XK-related protein STAT_alpha PF01017.20 KOO26698.1 - 0.015 15.2 0.9 0.037 13.9 0.9 1.6 1 0 0 1 1 1 0 STAT protein, all-alpha domain AAA_lid_3 PF17862.1 KOO26698.1 - 4.4 7.2 6.0 7.5 6.5 0.0 4.5 5 0 0 5 5 5 0 AAA+ lid domain EF-hand_6 PF13405.6 KOO26699.1 - 4.1e-13 48.1 4.3 0.0042 16.9 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO26699.1 - 9.8e-13 46.7 5.1 0.0059 16.1 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO26699.1 - 5.1e-10 39.7 2.2 1.7e-07 31.6 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO26699.1 - 1.1e-06 27.8 6.2 0.18 11.3 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO26699.1 - 0.00013 21.7 4.0 0.73 9.7 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO26699.1 - 0.026 14.5 2.4 2.3 8.2 0.1 3.0 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand SHOCT PF09851.9 KOO26699.1 - 0.14 12.0 0.4 7.6 6.4 0.1 2.6 2 0 0 2 2 2 0 Short C-terminal domain Helicase_C PF00271.31 KOO26700.1 - 3.1e-10 40.4 1.2 4.5e-10 39.8 1.2 1.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 KOO26702.1 - 3.3e-06 27.3 0.0 5.2e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOO26702.1 - 0.0016 18.8 0.0 0.0023 18.2 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DUF29 PF01724.16 KOO26703.1 - 0.034 14.4 0.2 0.045 14.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF29 TPR_1 PF00515.28 KOO26704.1 - 7.9e-16 57.1 3.3 1.3e-06 27.9 0.3 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO26704.1 - 6.7e-12 44.9 0.7 1.3e-06 27.9 0.0 3.2 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.17 KOO26704.1 - 6.9e-10 38.3 5.4 0.00079 19.4 0.1 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO26704.1 - 1.5e-06 28.5 0.0 0.097 13.5 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26704.1 - 1.6e-06 27.8 1.6 0.069 13.4 0.2 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO26704.1 - 0.00027 21.1 2.3 0.0085 16.4 0.4 2.7 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO26704.1 - 0.002 18.8 2.2 0.57 10.9 0.1 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO26704.1 - 0.0057 16.6 1.0 1.2 9.4 0.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO26704.1 - 0.016 14.4 0.1 0.026 13.8 0.1 1.3 1 1 0 1 1 1 0 Tetratricopeptide repeat RPN7 PF10602.9 KOO26704.1 - 0.017 14.8 0.6 0.12 12.0 0.6 2.0 1 1 0 1 1 1 0 26S proteasome subunit RPN7 TPR_9 PF13371.6 KOO26704.1 - 0.024 14.8 0.1 0.091 12.9 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO26704.1 - 0.027 14.8 0.2 1.3 9.6 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO26704.1 - 0.043 14.4 1.6 0.17 12.6 0.4 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO26704.1 - 0.045 14.0 1.8 0.1 12.8 1.8 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 KOO26704.1 - 0.062 13.3 0.2 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26704.1 - 0.066 13.7 1.6 3.5 8.2 0.4 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO26704.1 - 0.11 12.4 1.0 0.43 10.5 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26704.1 - 0.29 11.9 2.5 11 6.9 0.1 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat Pkinase PF00069.25 KOO26705.1 - 1.5e-43 149.0 0.0 6.5e-43 147.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO26705.1 - 6.8e-19 68.2 0.0 9.3e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO26705.1 - 0.044 13.7 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO26705.1 - 0.24 10.7 0.0 0.52 9.6 0.0 1.5 1 0 0 1 1 1 0 Kinase-like RNA_ligase PF09414.10 KOO26708.1 - 4.4e-23 82.4 0.0 7.4e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 RNA ligase AAA_33 PF13671.6 KOO26708.1 - 2.6e-12 47.1 1.6 1.1e-05 25.6 0.0 2.9 2 1 1 3 3 3 2 AAA domain AAA_18 PF13238.6 KOO26708.1 - 3.5e-07 30.8 0.1 0.01 16.4 0.0 2.5 1 1 1 2 2 2 2 AAA domain SKI PF01202.22 KOO26708.1 - 0.00024 21.3 0.0 0.71 10.0 0.0 3.1 3 0 0 3 3 3 2 Shikimate kinase tRNA_lig_kinase PF08303.11 KOO26708.1 - 0.0023 18.0 0.0 0.0051 16.9 0.0 1.7 1 1 0 1 1 1 1 tRNA ligase kinase domain MMR_HSR1 PF01926.23 KOO26708.1 - 0.0048 17.0 0.0 0.0093 16.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 KOO26708.1 - 0.012 14.9 0.4 0.031 13.5 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_5 PF07728.14 KOO26708.1 - 0.021 14.8 0.0 0.048 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO26708.1 - 0.023 15.1 0.2 0.078 13.4 0.2 2.0 1 1 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.10 KOO26708.1 - 0.025 14.0 0.2 0.09 12.2 0.2 1.8 1 1 0 1 1 1 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 KOO26708.1 - 0.042 14.4 0.0 0.082 13.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 KOO26708.1 - 0.043 14.1 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 KOO26708.1 - 0.047 13.6 0.0 1.9 8.3 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_28 PF13521.6 KOO26708.1 - 0.047 13.9 0.0 0.15 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 KOO26708.1 - 0.056 12.7 0.0 0.093 12.0 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_17 PF13207.6 KOO26708.1 - 0.2 12.1 0.2 0.72 10.3 0.1 1.9 1 1 1 2 2 2 0 AAA domain AAA PF00004.29 KOO26708.1 - 0.2 12.1 0.1 0.36 11.3 0.1 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) GlnD_UR_UTase PF08335.11 KOO26709.1 - 0.076 13.1 0.9 0.22 11.6 0.3 2.1 2 0 0 2 2 2 0 GlnD PII-uridylyltransferase Exostosin PF03016.15 KOO26711.1 - 2.3e-16 59.9 0.0 3.4e-15 56.1 0.0 2.1 1 1 0 1 1 1 1 Exostosin family TPR_2 PF07719.17 KOO26712.1 - 4.7 7.6 6.2 49 4.4 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO26712.1 - 5.1 8.2 15.5 2.8 9.0 1.9 3.7 2 2 1 3 3 3 0 Tetratricopeptide repeat ECH_2 PF16113.5 KOO26714.1 - 1.7e-48 165.9 0.0 1.9e-48 165.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KOO26714.1 - 4.3e-26 91.8 0.0 5.4e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Thioredoxin PF00085.20 KOO26715.1 - 7.1e-10 38.8 0.1 8.5e-10 38.5 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KOO26715.1 - 0.013 15.8 0.1 1.1 9.7 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin-like Reovirus_M2 PF05993.12 KOO26715.1 - 0.032 12.3 0.5 0.26 9.3 0.3 1.9 2 0 0 2 2 2 0 Reovirus major virion structural protein Mu-1/Mu-1C (M2) InvH PF04741.12 KOO26715.1 - 0.07 13.1 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 InvH outer membrane lipoprotein ERp29_N PF07912.13 KOO26715.1 - 0.13 12.4 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 ERp29, N-terminal domain DUF521 PF04412.13 KOO26717.1 - 1.7e-93 313.5 0.0 2.3e-93 313.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF521) DnaJ PF00226.31 KOO26718.1 - 4e-18 65.3 0.1 9.3e-18 64.1 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 KOO26718.1 - 2.4e-09 36.6 4.9 0.0037 17.3 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26718.1 - 1.3e-06 27.9 1.6 0.0065 16.3 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO26718.1 - 0.0072 16.6 7.6 0.23 11.7 4.7 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26718.1 - 0.012 16.1 2.9 0.037 14.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26718.1 - 0.029 15.0 4.1 0.62 10.8 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat SnoaL_2 PF12680.7 KOO26719.1 - 0.00095 19.8 0.0 0.0012 19.5 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 KOO26719.1 - 0.025 15.0 0.0 0.031 14.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Actin PF00022.19 KOO26720.1 - 5.2e-33 114.3 0.0 2.1e-16 59.6 0.0 2.9 2 1 0 2 2 2 2 Actin WD40 PF00400.32 KOO26721.1 - 3.3e-33 113.2 18.3 0.00013 22.6 0.1 11.5 12 0 0 12 12 12 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO26721.1 - 2.3e-14 53.5 1.0 0.036 14.3 0.0 7.3 4 2 3 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KOO26721.1 - 9.5e-05 22.8 5.9 3.5 8.2 0.0 5.3 7 0 0 7 7 7 3 PQQ-like domain Nucleoporin_N PF08801.11 KOO26721.1 - 0.0039 16.0 0.5 8.5 5.0 0.0 4.0 3 1 0 3 3 3 2 Nup133 N terminal like Reg_prop PF07494.11 KOO26721.1 - 0.0077 16.3 0.9 40 4.9 0.0 5.0 5 0 0 5 5 5 0 Two component regulator propeller zf-RING_2 PF13639.6 KOO26722.1 - 1.3e-12 47.8 9.0 2.4e-12 47.0 9.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO26722.1 - 7.3e-10 38.5 9.4 1.3e-09 37.8 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO26722.1 - 4.1e-08 32.9 4.8 6.7e-08 32.3 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO26722.1 - 1e-06 28.5 7.9 1.7e-06 27.8 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOO26722.1 - 1.2e-06 28.7 10.0 2.6e-06 27.6 10.0 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KOO26722.1 - 2.3e-06 27.3 5.5 3.9e-06 26.6 5.5 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KOO26722.1 - 2e-05 24.5 4.3 3.8e-05 23.6 4.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 KOO26722.1 - 0.00011 21.9 3.6 0.00025 20.7 3.6 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 KOO26722.1 - 0.00063 19.7 6.5 0.001 19.0 6.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 KOO26722.1 - 0.0016 18.0 5.6 0.0028 17.2 5.6 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 KOO26722.1 - 0.0063 16.5 4.8 0.012 15.7 4.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 KOO26722.1 - 0.032 14.4 0.0 0.076 13.2 0.0 1.6 1 0 0 1 1 1 0 U-box domain RINGv PF12906.7 KOO26722.1 - 0.31 11.2 8.1 0.58 10.3 8.1 1.5 1 0 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.6 KOO26722.1 - 0.53 10.3 3.7 3.8 7.5 1.4 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Baculo_RING PF05883.11 KOO26722.1 - 0.54 10.3 1.1 1.3 9.0 1.1 1.5 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-RING_4 PF14570.6 KOO26722.1 - 0.67 9.8 3.3 1.2 9.0 3.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 KOO26722.1 - 0.82 9.5 5.5 1.5 8.7 5.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 KOO26722.1 - 1.3 9.3 6.2 6 7.1 6.2 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 KOO26722.1 - 2.1 8.7 6.0 4.1 7.8 6.0 1.4 1 0 0 1 1 1 0 RING-like domain Filamin PF00630.19 KOO26723.1 - 1.3e-21 77.3 0.0 5.9e-14 52.7 0.0 4.7 4 2 0 4 4 4 4 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO26723.1 - 0.00099 19.4 0.0 1.7 9.0 0.0 4.6 5 0 0 5 5 5 1 Invasin, domain 3 PhoD PF09423.10 KOO26724.1 - 1.1e-11 44.4 0.0 4.3e-10 39.2 0.0 2.3 1 1 0 1 1 1 1 PhoD-like phosphatase HGTP_anticodon PF03129.20 KOO26725.1 - 1.3e-19 70.2 0.0 2.8e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KOO26725.1 - 4.6e-09 36.5 0.0 6.9e-08 32.7 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Dpy-30 PF05186.13 KOO26725.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Dpy-30 motif RIIa PF02197.17 KOO26725.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit GN3L_Grn1 PF08701.11 KOO26725.1 - 0.98 9.6 3.7 14 5.9 0.6 2.3 2 0 0 2 2 2 0 GNL3L/Grn1 putative GTPase Mito_carr PF00153.27 KOO26726.1 - 9.4e-17 60.7 9.5 8.1e-05 22.5 0.1 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Com_YlbF PF06133.11 KOO26727.1 - 0.47 11.1 8.5 4.7 7.9 7.4 2.2 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA TMPIT PF07851.13 KOO26727.1 - 0.53 9.5 2.0 0.81 8.9 2.0 1.2 1 0 0 1 1 1 0 TMPIT-like protein RUN PF02759.19 KOO26729.1 - 0.28 11.1 1.9 0.62 10.0 0.1 2.3 2 0 0 2 2 2 0 RUN domain YkyA PF10368.9 KOO26729.1 - 2.7 7.6 16.0 0.22 11.2 0.3 3.4 4 0 0 4 4 4 0 Putative cell-wall binding lipoprotein Ank_5 PF13857.6 KOO26730.1 - 0.042 14.2 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO26730.1 - 0.056 14.0 0.0 2.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeats (many copies) PBP PF01161.20 KOO26732.1 - 1e-09 38.8 0.0 1.7e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Glyco_hydro_76 PF03663.14 KOO26733.1 - 7.2e-17 61.9 0.0 9.1e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 KOO26733.1 - 0.057 12.5 0.0 0.083 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 HSP70 PF00012.20 KOO26734.1 - 7.6e-08 31.0 0.0 1e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein Pkinase PF00069.25 KOO26735.1 - 1.1e-54 185.6 0.0 1.3e-54 185.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO26735.1 - 2.7e-22 79.3 0.0 3.7e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO26735.1 - 0.0033 16.8 0.1 0.0054 16.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Plectin PF00681.20 KOO26735.1 - 0.047 13.6 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Plectin repeat FKBP_C PF00254.28 KOO26736.1 - 9.7e-27 93.1 0.0 1.5e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CSD PF00313.22 KOO26738.1 - 4.9e-17 61.5 0.0 7.6e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KOO26738.1 - 1.4e-05 24.7 0.1 2.6e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain RNA_pol PF00940.19 KOO26739.1 - 1.7e-133 445.5 0.0 2.6e-133 444.9 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 KOO26739.1 - 1.9e-13 50.6 5.9 4e-08 33.0 0.1 3.1 3 0 0 3 3 3 3 DNA-directed RNA polymerase N-terminal Ion_trans_2 PF07885.16 KOO26740.1 - 1.2e-16 60.4 18.1 1.9e-11 43.8 2.4 2.7 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 KOO26740.1 - 3e-06 26.7 0.5 3e-06 26.7 0.5 2.1 2 0 0 2 2 2 1 Ion transport protein Lig_chan PF00060.26 KOO26740.1 - 0.00015 21.6 0.1 0.0003 20.7 0.1 1.6 1 0 0 1 1 1 1 Ligand-gated ion channel IRK PF01007.20 KOO26740.1 - 0.045 13.6 0.6 0.045 13.6 0.6 3.0 3 1 0 3 3 3 0 Inward rectifier potassium channel transmembrane domain EF-hand_1 PF00036.32 KOO26741.1 - 8.3e-20 68.8 0.1 1.6e-05 24.1 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 KOO26741.1 - 5.8e-19 66.7 1.3 2.1e-07 30.1 0.1 3.6 3 1 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO26741.1 - 1.4e-17 63.9 3.0 2.5e-08 34.2 0.0 2.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO26741.1 - 1.2e-16 59.1 0.6 7.6e-05 22.3 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KOO26741.1 - 3.9e-15 55.4 0.3 0.00015 21.5 0.0 3.3 2 1 1 3 3 3 3 EF-hand domain pair Dockerin_1 PF00404.18 KOO26741.1 - 0.0085 16.3 0.2 0.51 10.6 0.0 2.8 3 0 0 3 3 3 1 Dockerin type I domain DUF533 PF04391.12 KOO26741.1 - 0.0086 15.7 0.9 0.091 12.3 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF533) SPARC_Ca_bdg PF10591.9 KOO26741.1 - 0.023 15.0 0.1 6.3 7.2 0.0 2.9 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region RNA_pol_Rpc82 PF05645.13 KOO26742.1 - 0.0021 17.9 0.0 0.0055 16.5 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase III subunit RPC82 HrpB1_HrpK PF09613.10 KOO26742.1 - 0.0052 16.4 0.2 0.012 15.3 0.2 1.6 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB1_HrpK) Acetyltransf_7 PF13508.7 KOO26743.1 - 6.2e-07 29.8 0.0 1.7e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO26743.1 - 1.7e-06 28.3 0.0 3.5e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOO26743.1 - 0.0016 18.4 0.0 0.0029 17.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain 2OG-FeII_Oxy_3 PF13640.6 KOO26743.1 - 0.0071 17.2 0.0 0.017 16.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Acetyltransf_CG PF14542.6 KOO26743.1 - 0.16 12.1 0.1 0.46 10.6 0.0 1.8 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase PX PF00787.24 KOO26745.1 - 0.00027 20.9 0.0 0.0006 19.8 0.0 1.5 1 0 0 1 1 1 1 PX domain DMA PF03474.14 KOO26745.1 - 0.43 10.2 2.1 5.2 6.8 0.1 2.4 2 0 0 2 2 2 0 DMRTA motif Annexin PF00191.20 KOO26746.1 - 7.4e-77 253.4 5.2 2e-11 43.8 0.3 8.4 8 0 0 8 8 8 8 Annexin PAS_9 PF13426.7 KOO26747.1 - 8e-74 244.5 0.0 1e-14 54.7 0.0 6.5 6 0 0 6 6 6 6 PAS domain PAS PF00989.25 KOO26747.1 - 5.8e-25 87.5 0.0 1.3e-05 25.1 0.0 6.1 6 0 0 6 6 6 5 PAS fold PAS_3 PF08447.12 KOO26747.1 - 8.7e-21 74.0 0.0 0.00084 19.6 0.0 5.7 5 0 0 5 5 5 5 PAS fold PAS_8 PF13188.7 KOO26747.1 - 4.9e-16 58.3 0.2 0.0013 18.7 0.0 6.2 6 0 0 6 6 6 4 PAS domain PAS_4 PF08448.10 KOO26747.1 - 3.7e-13 49.7 1.0 0.19 12.0 0.1 6.5 6 0 0 6 6 6 4 PAS fold RGS PF00615.19 KOO26747.1 - 0.0064 16.7 0.2 0.6 10.4 0.0 3.9 5 0 0 5 5 5 1 Regulator of G protein signaling domain DUF1719 PF08224.11 KOO26747.1 - 0.029 13.5 0.0 0.063 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1719) PAS_9 PF13426.7 KOO26748.1 - 4.1e-27 94.5 0.0 2.9e-15 56.4 0.0 3.0 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 KOO26748.1 - 1.6e-08 34.5 0.1 0.00043 20.2 0.0 3.2 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.7 KOO26748.1 - 1e-06 28.6 0.0 0.005 16.8 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 KOO26748.1 - 0.00011 22.4 0.0 0.0022 18.3 0.0 2.9 2 1 0 2 2 2 1 PAS fold RGS PF00615.19 KOO26748.1 - 0.00015 22.0 0.0 0.32 11.3 0.0 2.7 2 0 0 2 2 2 2 Regulator of G protein signaling domain PAS_4 PF08448.10 KOO26748.1 - 0.0023 18.2 0.4 0.71 10.1 0.0 3.3 3 0 0 3 3 3 1 PAS fold XkdW PF09636.10 KOO26748.1 - 0.02 15.0 0.4 0.063 13.4 0.4 1.9 1 0 0 1 1 1 0 XkdW protein zf_Rg PF17915.1 KOO26749.1 - 0.017 14.5 1.5 4.4 6.8 0.3 2.4 2 0 0 2 2 2 0 Reverse gyrase zinc finger zinc_ribbon_2 PF13240.6 KOO26749.1 - 0.06 13.1 4.5 3.3 7.6 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 KOO26749.1 - 0.12 11.9 0.9 1.9 8.1 0.0 2.6 2 0 0 2 2 2 0 TFIIB zinc-binding DUF2072 PF09845.9 KOO26749.1 - 0.14 12.4 0.5 23 5.2 0.1 2.4 2 0 0 2 2 2 0 Zn-ribbon containing protein TFIIS_C PF01096.18 KOO26749.1 - 1.5 8.8 7.5 20 5.2 0.1 4.3 5 0 0 5 5 5 0 Transcription factor S-II (TFIIS) zf-LITAF-like PF10601.9 KOO26749.1 - 2.2 8.6 7.0 3.1 8.1 0.3 3.1 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain TPMT PF05724.11 KOO26750.1 - 9.5e-17 61.4 0.1 6.5e-15 55.4 0.1 2.2 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 KOO26750.1 - 6.6e-05 23.5 0.0 0.00017 22.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO26750.1 - 0.00031 21.3 0.1 0.00083 20.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain GLTP PF08718.11 KOO26750.1 - 0.0018 18.6 0.0 0.003 17.8 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Methyltransf_12 PF08242.12 KOO26750.1 - 0.023 15.5 0.0 0.042 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Nop53 PF07767.11 KOO26751.1 - 4.3 6.6 21.8 5.5 6.3 21.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TAF4 PF05236.14 KOO26751.1 - 4.3 7.0 21.4 14 5.3 21.4 1.7 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Arm PF00514.23 KOO26752.1 - 5.7e-59 194.5 29.9 7.7e-08 32.1 0.3 9.7 9 0 0 9 9 9 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO26752.1 - 2.1e-12 47.3 30.1 0.003 18.0 0.1 6.6 4 2 4 8 8 8 7 HEAT-like repeat Atx10homo_assoc PF09759.9 KOO26752.1 - 4.7e-11 42.6 17.3 0.00044 20.2 1.0 6.9 2 2 5 8 8 8 4 Spinocerebellar ataxia type 10 protein domain CRS1_YhbY PF01985.21 KOO26752.1 - 0.0045 17.1 5.2 66 3.8 0.0 6.3 7 0 0 7 7 7 0 CRS1 / YhbY (CRM) domain Arm_2 PF04826.13 KOO26752.1 - 0.011 15.3 9.1 3.8 6.9 0.1 3.8 1 1 1 3 3 3 0 Armadillo-like Op_neuropeptide PF08035.11 KOO26752.1 - 1.8 8.5 9.0 2.9e+02 1.4 0.0 6.3 7 0 0 7 7 7 0 Opioids neuropeptide IMS PF00817.20 KOO26753.1 - 7.2e-41 139.7 0.1 1.1e-40 139.1 0.1 1.3 1 0 0 1 1 1 1 impB/mucB/samB family Pkinase PF00069.25 KOO26754.1 - 5e-50 170.3 0.0 6.9e-50 169.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO26754.1 - 1.6e-26 93.2 0.0 2.2e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO26754.1 - 0.014 14.2 0.0 0.014 14.2 0.0 2.4 2 1 1 3 3 3 0 Fungal protein kinase Kdo PF06293.14 KOO26754.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO26754.1 - 0.15 12.0 0.0 0.45 10.4 0.0 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO26754.1 - 0.16 11.3 0.0 2.3 7.5 0.0 2.1 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 KOO26754.1 - 0.16 11.6 0.0 0.38 10.3 0.0 1.7 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SRP-alpha_N PF04086.13 KOO26754.1 - 0.16 11.8 11.9 0.24 11.3 11.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SOG2 PF10428.9 KOO26754.1 - 0.54 9.4 5.6 0.75 8.9 5.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DUF4614 PF15391.6 KOO26754.1 - 3 7.8 8.7 5.5 6.9 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) DAGAT PF03982.13 KOO26756.1 - 6e-24 84.5 0.0 9.3e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol acyltransferase DOCK_N PF16172.5 KOO26756.1 - 0.18 10.7 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 DOCK N-terminus ABC_tran PF00005.27 KOO26757.1 - 7.8e-22 78.3 0.0 9.6e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOO26757.1 - 2.7e-11 43.8 0.8 7.1e-05 22.8 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 KOO26757.1 - 0.00023 21.5 0.1 0.00041 20.6 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOO26757.1 - 0.00032 21.0 0.5 0.0016 18.8 0.1 1.9 1 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOO26757.1 - 0.0006 19.6 1.2 0.0019 17.9 1.2 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO26757.1 - 0.0011 19.4 2.6 0.0016 18.8 2.6 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 KOO26757.1 - 0.0017 18.1 0.0 0.0033 17.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 KOO26757.1 - 0.013 15.1 0.0 0.026 14.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KOO26757.1 - 0.014 15.9 0.0 0.02 15.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 KOO26757.1 - 0.014 15.5 0.2 0.023 14.8 0.2 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO26757.1 - 0.022 14.6 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase SMC_N PF02463.19 KOO26757.1 - 0.023 14.1 0.1 0.9 8.9 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 KOO26757.1 - 0.027 14.1 1.8 0.095 12.3 1.7 2.2 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 KOO26757.1 - 0.035 13.8 0.0 0.06 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 KOO26757.1 - 0.04 13.8 4.0 0.37 10.7 0.1 2.4 2 1 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 KOO26757.1 - 0.079 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF3584 PF12128.8 KOO26757.1 - 0.17 9.3 0.0 0.23 9.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SbcCD_C PF13558.6 KOO26757.1 - 0.24 11.6 0.2 0.24 11.6 0.2 2.2 2 1 1 3 3 2 0 Putative exonuclease SbcCD, C subunit PP2C PF00481.21 KOO26758.1 - 2.7e-47 161.6 0.0 2.9e-47 161.5 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C MORN PF02493.20 KOO26759.1 - 8.3e-57 185.8 61.7 8.5e-07 28.5 0.6 10.6 10 0 0 10 10 10 10 MORN repeat Phage_base_V PF04717.12 KOO26759.1 - 0.026 14.5 0.4 2 8.4 0.0 3.4 4 0 0 4 4 4 0 Type VI secretion system, phage-baseplate injector DUF3048_C PF17479.2 KOO26759.1 - 5.3 7.5 18.0 3.1 8.2 1.8 4.6 1 1 3 5 5 5 0 Protein of unknown function (DUF3048) C-terminal domain KfrA_N PF11740.8 KOO26760.1 - 0.018 15.7 4.7 0.031 14.9 4.7 1.3 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term Histone PF00125.24 KOO26761.1 - 0.00038 20.8 0.1 0.057 13.8 0.0 3.0 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 Glyco_transf_25 PF01755.17 KOO26761.1 - 0.00061 19.7 0.0 0.0045 16.9 0.0 2.2 2 1 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) FAD_binding_7 PF03441.14 KOO26762.1 - 1.2e-60 204.5 0.5 1.9e-60 203.8 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KOO26762.1 - 1.4e-21 77.2 0.2 3e-10 40.4 2.5 2.6 2 0 0 2 2 2 2 DNA photolyase SURF4 PF02077.15 KOO26763.1 - 2.6e-48 165.0 2.1 3e-48 164.7 2.1 1.1 1 0 0 1 1 1 1 SURF4 family DoxX PF07681.12 KOO26763.1 - 0.069 13.8 14.5 2.5 8.7 8.5 3.0 2 1 0 2 2 2 0 DoxX Histone PF00125.24 KOO26764.1 - 4e-10 40.2 0.0 1.1e-06 29.0 0.0 2.3 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 KOO26764.1 - 0.002 18.2 0.0 0.18 11.9 0.0 2.4 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 KOO26764.1 - 0.085 13.0 0.0 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 KOO26764.1 - 0.11 12.5 0.0 0.49 10.4 0.0 2.0 2 0 0 2 2 2 0 Bromodomain associated UPF0137 PF03677.13 KOO26764.1 - 0.21 11.4 0.0 0.32 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) DNA_pol_phi PF04931.13 KOO26764.1 - 7.2 4.6 5.4 13 3.7 5.1 1.5 2 0 0 2 2 2 0 DNA polymerase phi SHIPPO-rpt PF07004.12 KOO26765.1 - 3.7e-09 37.1 19.6 0.0029 18.5 0.1 5.7 6 0 0 6 6 6 4 Sperm-tail PG-rich repeat Fasciclin PF02469.22 KOO26766.1 - 1.4e-32 112.6 0.0 2.1e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain S1 PF00575.23 KOO26766.1 - 2e-21 76.1 5.2 1.9e-10 41.0 0.1 2.6 1 1 1 2 2 2 2 S1 RNA binding domain MFS_1 PF07690.16 KOO26766.1 - 9.2e-12 44.5 34.8 3.1e-11 42.8 34.8 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 KOO26766.1 - 1e-11 43.8 2.3 1.6e-10 39.9 2.3 2.1 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family S1_2 PF13509.6 KOO26766.1 - 0.00024 21.1 0.1 0.15 12.1 0.1 2.6 2 1 0 2 2 2 2 S1 domain CSD PF00313.22 KOO26766.1 - 0.15 11.9 2.3 0.72 9.8 1.0 2.2 1 1 1 2 2 2 0 'Cold-shock' DNA-binding domain Misat_Tub_SegII PF10644.9 KOO26767.1 - 4.3e-19 69.0 0.0 7.4e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 KOO26767.1 - 1.6e-11 44.3 0.0 1.6e-10 40.9 0.0 2.4 3 0 0 3 3 3 1 Tubulin domain Tubulin PF00091.25 KOO26767.1 - 0.00017 21.8 0.0 0.17 12.0 0.0 2.3 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain COPIIcoated_ERV PF07970.12 KOO26769.1 - 2e-45 155.3 0.2 2.8e-45 154.8 0.2 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOO26769.1 - 6.4e-27 93.7 0.4 1.4e-26 92.7 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Mur_ligase_C PF02875.21 KOO26770.1 - 0.0096 16.2 0.1 0.06 13.6 0.0 2.2 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain EF-hand_6 PF13405.6 KOO26771.1 - 2.4e-09 36.4 0.4 0.00026 20.7 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO26771.1 - 6.3e-09 36.2 4.2 7.2e-06 26.4 0.3 2.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO26771.1 - 1.5e-07 30.4 0.2 7.3e-05 22.0 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO26771.1 - 1e-05 25.3 0.0 2.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair C2 PF00168.30 KOO26771.1 - 3.4e-05 24.1 0.0 0.0016 18.7 0.0 2.3 2 0 0 2 2 2 1 C2 domain EF-hand_5 PF13202.6 KOO26771.1 - 4.6e-05 22.7 0.6 0.32 10.6 0.3 2.5 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO26771.1 - 0.037 14.3 0.2 0.14 12.5 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_10 PF14788.6 KOO26771.1 - 0.099 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 EF hand SPRY PF00622.28 KOO26772.1 - 0.00032 20.8 0.0 0.0022 18.1 0.0 2.0 1 1 0 1 1 1 1 SPRY domain IF-2B PF01008.17 KOO26773.1 - 7.5e-59 199.2 0.0 9.3e-59 198.9 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family FAD_binding_3 PF01494.19 KOO26773.1 - 0.014 14.6 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain CBFD_NFYB_HMF PF00808.23 KOO26773.1 - 0.044 14.1 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Arm PF00514.23 KOO26774.1 - 1.2e-61 203.0 22.2 1.1e-12 47.5 0.1 8.9 8 1 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO26774.1 - 9.2e-18 64.4 12.3 7.5e-05 23.1 0.0 5.6 5 1 1 6 6 6 4 HEAT-like repeat Arm_3 PF16186.5 KOO26774.1 - 9.3e-18 63.5 0.8 1.9e-17 62.6 0.8 1.5 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.6 KOO26774.1 - 3.1e-14 53.1 1.0 0.0046 17.3 0.4 5.6 2 1 3 5 5 5 4 HEAT repeats IBB PF01749.20 KOO26774.1 - 2.5e-10 40.6 2.4 4.8e-10 39.7 1.4 2.0 2 0 0 2 2 2 1 Importin beta binding domain HEAT PF02985.22 KOO26774.1 - 7.4e-10 38.2 9.2 0.0038 17.3 0.0 6.7 8 0 0 8 8 8 2 HEAT repeat NopRA1 PF16201.5 KOO26774.1 - 0.00026 20.7 0.0 0.14 11.7 0.0 3.6 3 1 1 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 RICTOR_N PF14664.6 KOO26774.1 - 0.0012 17.9 0.4 0.51 9.3 0.2 2.9 3 1 0 3 3 3 2 Rapamycin-insensitive companion of mTOR, N-term Mo25 PF08569.11 KOO26774.1 - 0.035 13.5 0.0 0.39 10.0 0.0 2.1 1 1 1 2 2 2 0 Mo25-like Ric8 PF10165.9 KOO26774.1 - 0.048 12.7 0.0 0.3 10.1 0.0 2.1 1 1 1 2 2 2 0 Guanine nucleotide exchange factor synembryn RICTOR_V PF14668.6 KOO26774.1 - 0.065 13.5 1.5 13 6.1 0.0 4.1 4 1 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, domain 5 DUF3708 PF12501.8 KOO26774.1 - 0.08 12.7 1.3 0.29 10.9 0.1 2.4 3 0 0 3 3 3 0 Phosphate ATP-binding cassette transporter Proteasom_PSMB PF10508.9 KOO26774.1 - 0.12 10.9 0.1 0.21 10.1 0.1 1.3 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit Trehalase PF01204.18 KOO26775.1 - 3.2e-102 343.0 0.0 6.7e-52 177.0 0.0 2.0 1 1 1 2 2 2 2 Trehalase Glyco_hydro_92 PF07971.12 KOO26775.1 - 0.02 13.8 0.2 0.03 13.3 0.2 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 92 PDZ_6 PF17820.1 KOO26776.1 - 0.00021 21.0 0.0 0.00033 20.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO26776.1 - 0.00023 21.4 0.0 0.00028 21.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO26776.1 - 0.0039 17.5 0.1 0.0052 17.1 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PsbP PF01789.16 KOO26778.1 - 4.9e-12 46.2 0.0 9.5e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 PsbP EF-hand_5 PF13202.6 KOO26782.1 - 6e-129 414.4 133.3 8.8e-06 25.0 0.1 28.2 14 14 14 28 28 28 28 EF hand EF-hand_1 PF00036.32 KOO26782.1 - 2.7e-116 370.7 127.5 1.1e-05 24.6 0.5 28.2 11 11 17 28 28 28 28 EF hand EF-hand_6 PF13405.6 KOO26782.1 - 1.7e-106 339.2 124.2 0.00019 21.1 0.4 28.3 11 11 17 28 28 28 28 EF-hand domain EF-hand_7 PF13499.6 KOO26782.1 - 5.9e-85 279.7 87.0 4.6e-10 39.8 2.8 21.1 3 3 12 16 16 16 16 EF-hand domain pair EF-hand_8 PF13833.6 KOO26782.1 - 9.2e-51 169.5 121.1 0.0011 18.7 0.1 27.5 14 12 13 27 27 27 18 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO26782.1 - 2.1e-10 40.9 26.1 7.1 7.0 0.0 17.1 3 3 9 13 13 13 0 Secreted protein acidic and rich in cysteine Ca binding region SHOCT PF09851.9 KOO26782.1 - 1.1e-07 31.4 18.6 6.1 6.7 0.0 13.1 15 1 1 16 16 15 0 Short C-terminal domain EF-hand_4 PF12763.7 KOO26782.1 - 5e-07 29.6 28.7 0.25 11.3 0.2 11.2 4 3 8 13 13 13 1 Cytoskeletal-regulatory complex EF hand Trypan_PARP PF05887.11 KOO26782.1 - 0.00037 20.5 3.1 0.00081 19.4 3.1 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Dockerin_1 PF00404.18 KOO26782.1 - 0.0012 19.0 47.0 0.98 9.7 0.0 17.2 17 6 5 22 22 19 1 Dockerin type I domain Use1 PF09753.9 KOO26782.1 - 0.0024 17.6 4.4 0.0037 17.0 4.4 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 DUF4763 PF15960.5 KOO26782.1 - 0.022 14.1 4.2 0.036 13.4 4.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) DUF2782 PF11191.8 KOO26782.1 - 0.024 14.8 0.0 24 5.2 0.0 5.3 4 2 1 6 6 4 0 Protein of unknown function (DUF2782) Macoilin PF09726.9 KOO26782.1 - 0.093 11.3 4.0 0.12 10.9 4.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF4201 PF13870.6 KOO26782.1 - 0.1 12.3 11.9 0.025 14.3 7.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) MAD PF05557.13 KOO26782.1 - 0.14 10.5 7.8 0.11 10.8 6.5 1.3 1 1 0 1 1 1 0 Mitotic checkpoint protein SLATT_4 PF18186.1 KOO26782.1 - 0.15 11.7 0.7 0.26 10.9 0.7 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 ERM PF00769.19 KOO26782.1 - 0.18 11.6 15.3 0.11 12.3 10.3 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Caleosin PF05042.13 KOO26782.1 - 0.24 11.3 36.8 1.4 8.8 0.1 10.3 5 4 5 10 10 10 0 Caleosin related protein TolA_bind_tri PF16331.5 KOO26782.1 - 0.36 10.9 5.3 0.6 10.2 2.9 2.2 2 0 0 2 2 2 0 TolA binding protein trimerisation AAA_13 PF13166.6 KOO26782.1 - 0.6 8.7 3.9 0.88 8.1 3.9 1.1 1 0 0 1 1 1 0 AAA domain TonB_N PF16031.5 KOO26782.1 - 0.78 10.3 7.3 2.1 8.9 7.3 1.6 1 0 0 1 1 1 0 TonB polyproline region GAS PF13851.6 KOO26782.1 - 1.1 8.6 8.0 2.4 7.5 5.2 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 KOO26782.1 - 1.3 8.8 8.5 1.8 8.4 5.5 2.0 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH CENP-Q PF13094.6 KOO26782.1 - 1.9 8.7 9.9 2.3 8.4 8.6 1.8 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Spc7 PF08317.11 KOO26782.1 - 2.6 6.8 9.8 5.8 5.7 9.8 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein CENP-H PF05837.12 KOO26782.1 - 3.7 8.0 10.3 0.17 12.3 2.4 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Seryl_tRNA_N PF02403.22 KOO26782.1 - 4.1 7.7 7.3 2 8.7 4.6 1.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain YabA PF06156.13 KOO26782.1 - 4.3 8.0 8.7 3.6 8.3 0.1 2.6 1 1 0 2 2 2 0 Initiation control protein YabA BMFP PF04380.13 KOO26782.1 - 6.3 7.3 13.7 0.11 13.0 2.9 3.8 5 0 0 5 5 2 0 Membrane fusogenic activity FUSC PF04632.12 KOO26782.1 - 7 5.1 8.5 10 4.5 8.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TPD52 PF04201.15 KOO26782.1 - 8.1 6.0 8.0 25 4.4 0.1 2.3 1 1 1 2 2 2 0 Tumour protein D52 family Atg14 PF10186.9 KOO26782.1 - 9.1 5.3 10.0 5.6 5.9 8.2 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FrhB_FdhB_C PF04432.13 KOO26783.1 - 6e-21 74.9 0.0 9.4e-21 74.2 0.0 1.2 1 0 0 1 1 1 1 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus FrhB_FdhB_N PF04422.13 KOO26783.1 - 1.2e-14 54.2 0.0 2.4e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term LRR_5 PF13306.6 KOO26784.1 - 3.8e-89 295.2 3.6 1.1e-34 119.1 0.3 3.6 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO26784.1 - 3.2e-24 84.5 0.5 0.00046 19.9 0.0 10.9 7 2 5 12 12 12 7 Leucine rich repeat LRR_6 PF13516.6 KOO26784.1 - 3e-22 76.7 22.7 9.5e-05 22.2 0.0 11.2 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.7 KOO26784.1 - 0.0054 17.1 6.5 6.7 7.3 0.1 6.9 7 0 0 7 7 7 1 Leucine Rich repeats (2 copies) YL1 PF05764.13 KOO26785.1 - 0.019 15.1 1.7 0.031 14.4 1.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein EF-hand_7 PF13499.6 KOO26786.1 - 6.6e-15 55.3 0.0 3.2e-05 24.3 0.0 4.0 2 1 2 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO26786.1 - 4.7e-14 51.1 0.0 2.8e-05 23.7 0.0 4.8 5 0 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.32 KOO26786.1 - 1.2e-09 37.0 0.0 0.00084 18.7 0.0 4.5 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.6 KOO26786.1 - 7.5e-06 25.2 0.0 0.0062 16.0 0.0 4.0 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 KOO26786.1 - 1.5e-05 24.8 0.0 0.36 10.7 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair SET PF00856.28 KOO26787.1 - 1.5e-09 38.5 1.9 0.017 15.5 0.0 3.1 2 1 1 3 3 3 3 SET domain DUF1104 PF06518.11 KOO26787.1 - 0.0019 18.5 2.0 1.1 9.7 1.8 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1104) SAF PF08666.12 KOO26787.1 - 0.028 15.1 0.0 3.2 8.5 0.0 2.7 3 0 0 3 3 3 0 SAF domain Phage_GP20 PF06810.11 KOO26787.1 - 0.086 12.6 7.7 0.15 11.9 7.7 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 LRR_12 PF18837.1 KOO26788.1 - 0.029 14.0 0.2 0.029 14.0 0.2 2.1 2 0 0 2 2 2 0 Leucine-rich repeat Glyco_hydro_43 PF04616.14 KOO26789.1 - 6.2e-21 75.0 1.4 1.2e-20 74.1 1.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 WD40 PF00400.32 KOO26789.1 - 3.4e-09 37.2 6.7 0.00083 20.1 0.1 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat fn3 PF00041.21 KOO26789.1 - 2.2e-06 27.9 0.0 9e-06 25.9 0.0 2.1 1 0 0 1 1 1 1 Fibronectin type III domain F5_F8_type_C PF00754.25 KOO26789.1 - 2.6e-06 27.5 0.1 4.3e-05 23.6 0.1 2.8 1 1 0 1 1 1 1 F5/8 type C domain TFIIE-A_C PF11521.8 KOO26789.1 - 0.09 13.1 1.0 0.19 12.0 1.0 1.5 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Nup160 PF11715.8 KOO26789.1 - 0.13 10.9 0.0 0.54 8.8 0.0 1.9 2 0 0 2 2 2 0 Nucleoporin Nup120/160 DUF4604 PF15377.6 KOO26789.1 - 0.6 10.5 6.8 5.8 7.3 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Morc6_S5 PF17942.1 KOO26791.1 - 0.014 15.4 0.0 3.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Morc6 ribosomal protein S5 domain 2-like ORC_WH_C PF18137.1 KOO26791.1 - 0.048 13.7 0.6 0.076 13.1 0.6 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Complex1_LYR PF05347.15 KOO26792.1 - 0.00099 19.1 0.2 0.00099 19.1 0.2 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOO26792.1 - 0.0081 16.9 0.3 0.012 16.4 0.3 1.3 1 1 0 1 1 1 1 Complex1_LYR-like SpoU_methylase PF00588.19 KOO26793.1 - 1.5e-17 64.1 0.0 9e-17 61.6 0.0 2.0 1 1 0 1 1 1 1 SpoU rRNA Methylase family EF-hand_7 PF13499.6 KOO26794.1 - 3.8e-12 46.5 3.5 6.8e-12 45.7 3.4 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO26794.1 - 8.4e-12 44.0 3.4 1.9e-05 24.2 0.5 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO26794.1 - 7.9e-10 37.6 13.5 3.8e-06 26.0 0.7 2.6 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KOO26794.1 - 6.9e-09 34.8 10.6 0.00013 21.3 0.5 2.8 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 KOO26794.1 - 3.7e-07 30.5 0.2 4.4e-07 30.2 0.2 1.1 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KOO26794.1 - 4.7e-07 29.6 7.2 0.00083 19.1 0.8 2.5 1 1 2 3 3 3 2 EF-hand domain pair Dockerin_1 PF00404.18 KOO26794.1 - 0.002 18.3 0.1 0.049 13.8 0.2 2.3 1 1 1 2 2 2 2 Dockerin type I domain GvpO PF05800.11 KOO26794.1 - 0.061 13.3 0.1 0.076 13.0 0.1 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpO COX6C PF02937.15 KOO26794.1 - 0.12 12.5 0.1 0.21 11.8 0.1 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc Chloroa_b-bind PF00504.21 KOO26795.1 - 2.7e-36 125.6 0.0 3.5e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Glyco_transf_8 PF01501.20 KOO26796.1 - 1.8e-08 34.2 0.3 2e-07 30.8 0.3 2.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 LRR_6 PF13516.6 KOO26799.1 - 2.6e-31 105.0 30.9 0.00053 19.8 0.1 10.7 10 1 0 10 10 10 7 Leucine Rich repeat LRR_4 PF12799.7 KOO26799.1 - 1.6e-05 25.2 8.7 0.047 14.1 0.1 6.1 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) NACHT PF05729.12 KOO26799.1 - 0.00049 20.0 0.1 0.0011 19.0 0.1 1.5 1 0 0 1 1 1 1 NACHT domain SpoU_sub_bind PF08032.12 KOO26799.1 - 0.12 12.7 4.7 2.1 8.7 0.1 4.2 3 1 1 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding DUF5471 PF17565.2 KOO26799.1 - 0.22 11.8 5.0 5.3 7.4 2.0 3.4 2 0 0 2 2 2 0 Family of unknown function (DUF5471) LRR_8 PF13855.6 KOO26799.1 - 1.3 8.8 11.6 4.6 7.1 0.0 5.1 5 2 0 5 5 5 0 Leucine rich repeat CbiG_N PF11760.8 KOO26799.1 - 2.4 8.2 20.4 9.1 6.4 0.1 6.7 8 0 0 8 8 8 0 Cobalamin synthesis G N-terminal HOASN PF14515.6 KOO26799.1 - 2.8 8.4 21.7 0.27 11.6 1.4 6.4 3 2 5 8 8 8 0 Haem-oxygenase-associated N-terminal helices DUF4033 PF13225.6 KOO26800.1 - 2.5e-12 46.6 0.3 4e-12 45.9 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4033) Ank_2 PF12796.7 KOO26801.1 - 5.5e-09 36.5 1.1 3.8e-06 27.4 0.8 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) 2OG-FeII_Oxy_3 PF13640.6 KOO26801.1 - 1e-08 35.9 0.0 2.8e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ank_4 PF13637.6 KOO26801.1 - 0.0028 18.2 0.8 1.6 9.4 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO26801.1 - 0.0069 16.7 2.8 11 6.5 0.0 4.3 3 1 1 4 4 4 1 Ankyrin repeats (many copies) zf-RanBP PF00641.18 KOO26801.1 - 0.04 13.2 6.4 0.047 13.0 2.7 2.7 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others FAM24 PF15193.6 KOO26801.1 - 1.2 9.9 3.8 0.73 10.6 0.0 2.5 2 0 0 2 2 2 0 FAM24 family Cupin_8 PF13621.6 KOO26802.1 - 2.4e-41 142.2 0.0 4e-41 141.4 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO26802.1 - 0.00011 21.8 0.5 0.011 15.3 0.0 3.3 4 0 0 4 4 4 1 Cupin superfamily protein Hint PF01079.20 KOO26803.1 - 4.6e-12 45.9 0.6 7.9e-12 45.1 0.1 1.6 2 0 0 2 2 2 1 Hint module Sod_Cu PF00080.20 KOO26803.1 - 1.5e-07 31.7 11.3 9.3e-05 22.6 0.8 3.0 2 1 0 2 2 2 2 Copper/zinc superoxide dismutase (SODC) Pyridox_ox_2 PF12900.7 KOO26803.1 - 0.009 16.0 0.9 1.1 9.2 0.1 2.5 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase Exostosin PF03016.15 KOO26804.1 - 0.0036 16.6 0.0 0.0059 15.8 0.0 1.3 1 0 0 1 1 1 1 Exostosin family Pyr_redox_2 PF07992.14 KOO26805.1 - 7.9e-37 127.1 4.0 5.3e-22 78.4 0.8 2.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO26805.1 - 1.4e-16 60.7 6.4 1.3e-09 37.7 0.0 3.6 3 1 1 4 4 4 3 Pyridine nucleotide-disulphide oxidoreductase Thioredoxin PF00085.20 KOO26805.1 - 4.7e-15 55.4 0.5 2.4e-14 53.2 0.2 2.3 2 0 0 2 2 2 1 Thioredoxin FAD_oxidored PF12831.7 KOO26805.1 - 4.5e-06 26.3 2.3 5.3e-06 26.0 0.4 2.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOO26805.1 - 2.1e-05 25.0 5.6 0.19 12.3 0.4 4.0 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO26805.1 - 7.7e-05 21.6 2.8 0.028 13.1 2.4 2.7 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 KOO26805.1 - 0.00029 21.0 0.2 0.001 19.3 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO26805.1 - 0.00034 19.8 7.3 0.00056 19.1 2.0 2.8 2 1 0 2 2 2 1 FAD binding domain GIDA PF01134.22 KOO26805.1 - 0.00035 19.8 4.5 0.0013 17.9 0.8 3.1 3 0 0 3 3 3 1 Glucose inhibited division protein A NAD_binding_7 PF13241.6 KOO26805.1 - 0.0007 20.0 3.4 1.9 9.0 0.0 3.7 3 1 1 4 4 4 2 Putative NAD(P)-binding Thi4 PF01946.17 KOO26805.1 - 0.0067 15.7 3.8 0.021 14.0 0.9 2.5 2 0 0 2 2 2 1 Thi4 family Thioredoxin_8 PF13905.6 KOO26805.1 - 0.033 14.5 0.0 0.09 13.1 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like DAO PF01266.24 KOO26805.1 - 0.045 13.3 7.4 0.87 9.1 7.3 3.0 1 1 0 1 1 1 0 FAD dependent oxidoreductase Armet PF10208.9 KOO26805.1 - 0.07 13.1 2.6 0.11 12.5 0.2 2.3 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding Redoxin PF08534.10 KOO26805.1 - 0.086 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Redoxin FAD_binding_3 PF01494.19 KOO26805.1 - 0.13 11.5 4.4 0.1 11.8 0.8 2.5 3 0 0 3 3 3 0 FAD binding domain Imm50 PF15594.6 KOO26806.1 - 0.08 13.2 0.1 0.19 11.9 0.1 1.8 1 1 0 1 1 1 0 Immunity protein 50 AAA PF00004.29 KOO26807.1 - 6.9e-22 78.3 0.2 1.9e-21 76.9 0.1 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) LRR_6 PF13516.6 KOO26807.1 - 2.1e-09 36.7 2.9 0.061 13.4 0.2 4.7 4 0 0 4 4 4 3 Leucine Rich repeat AAA_5 PF07728.14 KOO26807.1 - 0.0014 18.7 0.0 0.0031 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOO26807.1 - 0.0024 17.7 0.0 0.088 12.5 0.0 2.7 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KOO26807.1 - 0.01 16.0 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO26807.1 - 0.064 13.6 0.3 0.4 11.1 0.3 2.3 1 1 0 1 1 1 0 AAA ATPase domain Cas_Csy3 PF09615.10 KOO26807.1 - 0.3 10.4 0.1 2.9 7.1 0.0 2.0 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy3) SR-25 PF10500.9 KOO26807.1 - 0.67 9.5 2.2 1.2 8.7 2.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_22 PF13401.6 KOO26807.1 - 0.71 10.1 2.6 31 4.9 2.6 2.7 1 1 0 1 1 1 0 AAA domain Hexapep PF00132.24 KOO26808.1 - 0.0051 16.5 2.8 0.0051 16.5 2.8 1.8 2 0 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) K_oxygenase PF13434.6 KOO26808.1 - 0.013 14.7 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Acetyltransf_2 PF00797.17 KOO26809.1 - 3.7e-57 193.9 0.0 4.5e-57 193.6 0.0 1.0 1 0 0 1 1 1 1 N-acetyltransferase Ribosomal_L12_N PF16320.5 KOO26809.1 - 0.37 10.5 1.8 0.34 10.7 0.2 1.8 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain MSV199 PF10553.9 KOO26810.1 - 0.1 12.8 0.6 0.2 11.9 0.6 1.4 1 0 0 1 1 1 0 MSV199 domain DUF1295 PF06966.12 KOO26811.1 - 3.9e-43 147.7 0.7 4.6e-43 147.4 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 KOO26811.1 - 0.0027 18.1 0.4 0.0047 17.3 0.4 1.6 1 1 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 KOO26811.1 - 0.029 14.8 0.2 0.061 13.7 0.2 1.7 1 0 0 1 1 1 0 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 KOO26811.1 - 0.031 13.0 1.6 0.049 12.4 1.6 1.3 1 1 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family UvrD-helicase PF00580.21 KOO26812.1 - 1e-09 38.4 0.0 1.6e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 KOO26812.1 - 5.3e-09 36.6 0.0 1.7e-08 35.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOO26812.1 - 0.0044 16.8 0.0 1.6 8.4 0.0 2.6 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 KOO26812.1 - 0.015 15.0 0.0 3 7.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Acyltransferase PF01553.21 KOO26814.1 - 3.9e-11 42.7 0.0 6e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase DAGAT PF03982.13 KOO26814.1 - 7.6e-08 31.6 0.6 1.3e-06 27.6 0.6 2.1 1 1 0 1 1 1 1 Diacylglycerol acyltransferase Peptidase_A22B PF04258.13 KOO26815.1 - 4e-51 174.2 7.7 6.3e-51 173.6 7.7 1.2 1 0 0 1 1 1 1 Signal peptide peptidase Exostosin PF03016.15 KOO26816.1 - 9.1e-13 48.1 0.0 1.7e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Exostosin family Cpn10 PF00166.21 KOO26817.1 - 1.4e-44 150.1 0.4 2.4e-21 75.6 0.1 2.1 2 0 0 2 2 2 2 Chaperonin 10 Kd subunit TRAM PF01938.20 KOO26817.1 - 0.093 12.7 0.2 0.33 11.0 0.0 2.0 2 0 0 2 2 2 0 TRAM domain SasG_E PF17041.5 KOO26817.1 - 0.16 12.0 0.9 0.31 11.1 0.9 1.5 1 0 0 1 1 1 0 E domain Melibiase_C PF17801.1 KOO26819.1 - 4.2e-09 36.3 0.0 1.3e-08 34.8 0.0 1.8 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2 PF16499.5 KOO26819.1 - 6.1e-08 32.2 1.5 0.071 12.3 0.1 3.2 2 1 0 3 3 3 3 Alpha galactosidase A EMI PF07546.13 KOO26819.1 - 0.1 13.4 0.4 21 6.0 0.0 2.6 2 0 0 2 2 2 0 EMI domain SHIPPO-rpt PF07004.12 KOO26821.1 - 0.00014 22.6 2.8 0.28 12.2 1.2 2.8 2 0 0 2 2 2 2 Sperm-tail PG-rich repeat Methyltransf_21 PF05050.12 KOO26824.1 - 0.028 14.4 0.0 0.055 13.5 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase FkbM domain PCIF1_WW PF12237.8 KOO26827.1 - 1.3e-39 135.6 0.1 3.6e-39 134.1 0.1 1.8 2 0 0 2 2 2 1 Phosphorylated CTD interacting factor 1 WW domain UBA PF00627.31 KOO26827.1 - 0.039 13.9 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 UBA/TS-N domain TBCC PF07986.12 KOO26828.1 - 3e-23 81.8 2.1 3.8e-23 81.5 2.1 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 KOO26828.1 - 0.031 13.9 9.4 0.11 12.1 9.4 1.7 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal ATP-synt_ab PF00006.25 KOO26830.1 - 2e-60 204.1 0.0 3.3e-60 203.4 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KOO26830.1 - 3.3e-22 78.8 3.5 6.8e-22 77.8 3.5 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 KOO26830.1 - 0.0091 15.4 0.2 0.017 14.5 0.2 1.5 1 0 0 1 1 1 1 KaiC AAA_19 PF13245.6 KOO26830.1 - 0.058 13.7 0.2 0.17 12.2 0.2 1.7 1 0 0 1 1 1 0 AAA domain RecA PF00154.21 KOO26830.1 - 0.062 12.8 0.5 0.14 11.6 0.2 1.7 2 0 0 2 2 2 0 recA bacterial DNA recombination protein AAA_16 PF13191.6 KOO26830.1 - 0.068 13.6 0.2 0.4 11.1 0.2 2.3 2 1 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 KOO26830.1 - 0.085 12.0 0.7 0.13 11.4 0.2 1.5 2 0 0 2 2 2 0 NB-ARC domain Methyltransf_16 PF10294.9 KOO26831.1 - 5.1e-19 68.7 0.0 8.1e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase EF-hand_7 PF13499.6 KOO26831.1 - 5.2e-08 33.2 0.0 2e-07 31.4 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair Methyltransf_31 PF13847.6 KOO26831.1 - 8.7e-07 28.9 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO26831.1 - 1.7e-06 27.7 0.0 3.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KOO26831.1 - 1.8e-06 27.6 0.3 4.2e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain EF-hand_1 PF00036.32 KOO26831.1 - 3.4e-05 23.1 0.0 0.002 17.6 0.0 2.9 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO26831.1 - 3.4e-05 23.4 0.5 0.0049 16.7 0.0 3.3 2 1 0 2 2 2 1 EF-hand domain Methyltransf_25 PF13649.6 KOO26831.1 - 0.00025 21.7 0.0 0.00062 20.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_9 PF14658.6 KOO26831.1 - 0.0073 16.6 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain Methyltransf_12 PF08242.12 KOO26831.1 - 0.012 16.3 0.0 0.034 14.9 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_8 PF13833.6 KOO26831.1 - 0.014 15.3 0.7 2.1 8.3 0.1 3.1 1 1 2 3 3 3 0 EF-hand domain pair NNMT_PNMT_TEMT PF01234.17 KOO26831.1 - 0.085 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Met_10 PF02475.16 KOO26831.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_23 PF13489.6 KOO26831.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_5 PF13202.6 KOO26831.1 - 0.29 10.7 1.7 2.9 7.6 0.0 2.8 3 0 0 3 3 2 0 EF hand Na_Ca_ex PF01699.24 KOO26832.1 - 3.2e-35 121.3 42.5 1.6e-18 67.1 16.6 2.7 2 1 0 2 2 2 2 Sodium/calcium exchanger protein PIH1 PF08190.12 KOO26833.1 - 2.4e-26 92.2 3.9 7.1e-26 90.7 0.0 2.9 3 1 1 4 4 4 1 PIH1 N-terminal domain PIH1_CS PF18201.1 KOO26833.1 - 6.7e-23 81.0 0.0 1.5e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 PIH1 CS-like domain Aa_trans PF01490.18 KOO26834.1 - 5.7e-39 134.0 19.9 7.6e-39 133.6 19.9 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein UQ_con PF00179.26 KOO26835.1 - 9.7e-38 129.0 0.1 1e-37 128.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KOO26835.1 - 0.0034 17.2 0.1 0.0046 16.8 0.1 1.2 1 0 0 1 1 1 1 UEV domain DNAJ_related PF12339.8 KOO26835.1 - 0.14 12.4 0.0 0.19 11.9 0.0 1.1 1 0 0 1 1 1 0 DNA-J related protein DUF1538 PF07556.11 KOO26837.1 - 4e-98 326.9 31.4 4.4e-53 179.7 15.4 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1538) RRM_1 PF00076.22 KOO26839.1 - 2.9e-12 46.2 0.0 0.00011 21.9 0.1 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GYF_2 PF14237.6 KOO26839.1 - 1.3e-05 24.8 0.1 3.3e-05 23.6 0.1 1.7 1 0 0 1 1 1 1 GYF domain 2 EF-hand_7 PF13499.6 KOO26841.1 - 2.7e-13 50.1 2.7 1.1e-10 41.8 0.1 3.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO26841.1 - 1.2e-11 43.3 4.7 2.1e-05 23.7 0.0 4.8 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.6 KOO26841.1 - 5.4e-11 41.5 0.8 0.00028 20.6 0.0 4.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KOO26841.1 - 6e-07 28.7 0.6 0.0049 16.3 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO26841.1 - 7.6e-07 28.9 5.8 0.0021 17.8 0.0 4.0 4 1 1 5 5 5 2 EF-hand domain pair fn3 PF00041.21 KOO26841.1 - 0.00037 20.8 0.2 0.00075 19.8 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III domain p25-alpha PF05517.12 KOO26841.1 - 0.17 12.1 0.8 3.9 7.6 0.2 3.0 2 1 0 2 2 2 0 p25-alpha BCNT PF07572.12 KOO26843.1 - 5.4e-17 61.6 1.5 9.5e-17 60.8 1.5 1.4 1 0 0 1 1 1 1 Bucentaur or craniofacial development zf-met PF12874.7 KOO26843.1 - 0.056 13.8 0.1 0.096 13.1 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type KASH_CCD PF14662.6 KOO26846.1 - 0.00016 21.6 5.4 0.00016 21.6 5.4 2.1 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH YabA PF06156.13 KOO26846.1 - 0.0012 19.5 4.7 0.04 14.5 1.4 2.6 2 1 1 3 3 3 1 Initiation control protein YabA CALCOCO1 PF07888.11 KOO26846.1 - 0.0032 16.4 13.4 0.0032 16.4 13.4 1.9 1 1 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like Acyl_transf_1 PF00698.21 KOO26846.1 - 0.0066 16.0 2.7 0.0087 15.6 2.7 1.1 1 0 0 1 1 1 1 Acyl transferase domain ATG16 PF08614.11 KOO26846.1 - 0.016 15.4 22.6 1.3 9.2 9.0 3.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) PI3K_P85_iSH2 PF16454.5 KOO26846.1 - 0.047 13.3 1.3 0.085 12.5 1.3 1.4 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Phage_GP20 PF06810.11 KOO26846.1 - 0.071 12.9 3.7 0.14 12.0 3.7 1.6 1 0 0 1 1 1 0 Phage minor structural protein GP20 CortBP2 PF09727.9 KOO26846.1 - 0.16 11.9 13.7 0.23 11.3 10.9 1.9 1 1 1 2 2 2 0 Cortactin-binding protein-2 PhageMin_Tail PF10145.9 KOO26846.1 - 0.28 11.0 13.9 0.4 10.5 13.9 1.1 1 0 0 1 1 1 0 Phage-related minor tail protein Nup88 PF10168.9 KOO26846.1 - 0.69 7.7 9.8 0.8 7.4 9.8 1.1 1 0 0 1 1 1 0 Nuclear pore component CENP-F_leu_zip PF10473.9 KOO26846.1 - 1.1 9.3 14.8 3.3 7.7 0.3 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 KOO26846.1 - 1.3 8.2 15.7 0.14 11.5 10.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4140 PF13600.6 KOO26846.1 - 1.6 9.2 0.0 1.6 9.2 0.0 3.6 2 1 0 2 2 1 0 N-terminal domain of unknown function (DUF4140) DUF4201 PF13870.6 KOO26846.1 - 7.7 6.2 11.8 3.8 7.2 4.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) WD40 PF00400.32 KOO26847.1 - 2.6e-43 145.2 15.6 7.7e-10 39.2 0.4 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO26847.1 - 5.2e-16 58.5 4.2 0.011 14.8 0.0 5.0 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO26847.1 - 6e-14 52.1 2.1 0.066 13.5 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO26847.1 - 1.1e-09 38.0 3.3 1.7 8.7 0.0 5.4 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO26847.1 - 5.9e-08 31.5 0.0 0.029 12.7 0.0 3.5 1 1 3 4 4 4 4 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KOO26847.1 - 1.5e-07 31.5 1.0 0.00035 20.5 0.5 2.9 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 KOO26847.1 - 2.5e-07 30.7 0.2 0.0012 18.9 0.1 3.5 2 1 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 KOO26847.1 - 1.4e-05 24.6 6.0 1.8 7.9 0.2 4.4 1 1 4 5 5 5 4 Neuroblastoma-amplified sequence, N terminal POLO_box PF00659.18 KOO26847.1 - 1.5e-05 25.1 0.2 31 4.8 0.0 5.3 2 2 2 4 4 4 0 POLO box duplicated region LigD_N PF13298.6 KOO26847.1 - 1.8e-05 25.0 4.1 0.65 10.3 0.0 4.7 1 1 3 4 4 4 2 DNA polymerase Ligase (LigD) Cytochrom_D1 PF02239.16 KOO26847.1 - 0.00011 20.9 0.2 0.00092 17.8 0.1 2.2 1 1 1 2 2 2 1 Cytochrome D1 heme domain Utp8 PF10395.9 KOO26847.1 - 0.0062 15.1 0.0 8.9 4.7 0.0 3.1 1 1 3 4 4 4 2 Utp8 family WD40_like PF17005.5 KOO26847.1 - 0.0082 15.5 0.6 1.7 7.9 0.1 2.6 2 1 0 3 3 3 1 WD40-like domain CIDE-N PF02017.15 KOO26847.1 - 0.011 15.8 0.0 12 6.0 0.0 3.9 4 0 0 4 4 4 0 CIDE-N domain dsrm PF00035.26 KOO26847.1 - 0.42 11.4 2.9 11 6.8 0.2 3.6 3 1 1 4 4 4 0 Double-stranded RNA binding motif Phosphoesterase PF04185.14 KOO26848.1 - 1.5e-51 175.7 0.0 2.6e-51 174.9 0.0 1.4 1 1 0 1 1 1 1 Phosphoesterase family Arm PF00514.23 KOO26849.1 - 7.1e-14 51.3 8.3 0.00094 19.1 0.1 4.0 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KOO26849.1 - 1.7e-05 24.9 0.0 0.027 14.5 0.0 2.1 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KOO26849.1 - 0.023 15.2 0.3 0.023 15.2 0.3 3.8 2 1 2 4 4 4 0 HEAT-like repeat HEAT_2 PF13646.6 KOO26849.1 - 0.044 14.2 15.8 0.2 12.0 6.8 2.6 1 1 1 2 2 2 0 HEAT repeats HEAT PF02985.22 KOO26849.1 - 0.044 14.0 7.1 4.2 7.9 0.0 4.0 3 2 1 4 4 4 0 HEAT repeat Aha1_N PF09229.11 KOO26850.1 - 5.5e-16 59.0 0.3 8.9e-16 58.3 0.3 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal PDZ_6 PF17820.1 KOO26850.1 - 7e-05 22.6 0.8 0.00025 20.8 0.3 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO26850.1 - 0.00029 21.1 0.0 0.00062 20.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 KOO26850.1 - 0.0027 18.1 0.0 0.0046 17.3 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain LRR_6 PF13516.6 KOO26850.1 - 0.0053 16.7 0.5 0.63 10.2 0.0 3.1 3 0 0 3 3 3 1 Leucine Rich repeat MCM PF00493.23 KOO26850.1 - 0.15 11.1 0.1 0.27 10.3 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain FAP PF07174.11 KOO26850.1 - 6.3 6.2 17.3 9.7 5.5 17.3 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Amidohydro_2 PF04909.14 KOO26852.1 - 1.2e-19 71.2 0.3 1.9e-19 70.5 0.3 1.3 1 0 0 1 1 1 1 Amidohydrolase TPR_1 PF00515.28 KOO26854.1 - 4.4e-20 70.6 0.2 5.3e-05 22.9 0.4 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO26854.1 - 6.9e-19 66.4 1.8 0.00015 21.6 0.5 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO26854.1 - 7.1e-10 38.6 2.9 0.0059 16.9 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26854.1 - 5.5e-09 35.6 0.0 0.017 15.3 0.1 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO26854.1 - 1.4e-08 34.8 16.0 0.00037 20.6 1.6 3.4 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO26854.1 - 7.7e-08 32.9 9.9 7.4e-05 23.3 2.0 2.9 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO26854.1 - 2e-07 30.5 2.1 0.00089 18.9 0.2 3.6 3 1 1 4 4 4 2 TPR repeat PH PF00169.29 KOO26854.1 - 1.5e-06 28.7 0.0 2.5e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 PH domain TPR_12 PF13424.6 KOO26854.1 - 4.6e-05 23.6 6.9 0.006 16.8 0.6 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO26854.1 - 0.00025 21.6 17.5 0.081 13.8 0.7 5.9 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO26854.1 - 0.018 15.0 3.3 19 5.6 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26854.1 - 0.09 13.3 5.1 0.22 12.1 2.4 2.8 1 1 1 2 2 2 0 Tetratricopeptide repeat PDZ_6 PF17820.1 KOO26854.1 - 0.092 12.6 0.3 0.27 11.1 0.3 1.8 1 0 0 1 1 1 0 PDZ domain TPR_21 PF09976.9 KOO26854.1 - 0.29 10.8 3.2 4 7.1 0.6 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain BTAD PF03704.17 KOO26854.1 - 0.3 11.5 9.7 10 6.5 7.1 2.8 1 1 1 2 2 2 0 Bacterial transcriptional activator domain UAA PF08449.11 KOO26855.1 - 2.1e-53 181.5 16.7 2.5e-53 181.3 16.7 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO26855.1 - 8.4e-06 26.0 23.4 0.0015 18.7 1.3 3.1 2 1 1 3 3 3 2 EamA-like transporter family CRT-like PF08627.10 KOO26855.1 - 0.0002 20.4 1.9 0.0002 20.4 1.9 2.0 1 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 KOO26855.1 - 0.0005 19.5 13.2 0.00069 19.1 13.2 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family Pkinase PF00069.25 KOO26855.1 - 0.11 11.9 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 Protein kinase domain Pro_isomerase PF00160.21 KOO26856.1 - 2.2e-12 47.5 0.0 3.3e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD LLC1 PF14945.6 KOO26858.1 - 1.6e-05 25.5 1.9 2.3e-05 25.0 0.3 2.0 3 0 0 3 3 3 1 Normal lung function maintenance, Low in Lung Cancer 1 protein FAM183 PF14886.6 KOO26858.1 - 0.00056 20.6 0.0 0.00077 20.2 0.0 1.6 1 1 0 1 1 1 1 FAM183A and FAM183B related PAE PF03283.13 KOO26860.1 - 1.8e-38 132.6 0.0 2.3e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 Pectinacetylesterase zf-C3HC4_3 PF13920.6 KOO26861.1 - 1e-10 41.3 9.7 1.4e-10 40.9 9.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO26861.1 - 0.0064 16.3 10.6 0.0094 15.8 10.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOO26861.1 - 0.026 14.9 10.0 0.041 14.2 10.0 1.3 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 KOO26861.1 - 0.7 9.9 10.7 1.7 8.7 10.7 1.6 1 1 1 2 2 2 0 zinc-RING finger domain Pkinase_Tyr PF07714.17 KOO26862.1 - 6.4e-32 110.8 0.0 1.1e-31 110.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO26862.1 - 3.7e-31 108.5 0.0 6.8e-31 107.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain LRR_8 PF13855.6 KOO26862.1 - 5.2e-07 29.3 0.2 1.1e-06 28.3 0.2 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KOO26862.1 - 0.00011 22.5 0.2 0.0004 20.7 0.2 2.0 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) RRM_1 PF00076.22 KOO26862.1 - 0.0012 18.6 0.1 0.02 14.7 0.0 3.0 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) APH PF01636.23 KOO26862.1 - 0.0051 16.8 0.8 0.039 13.9 0.4 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO26862.1 - 0.016 14.5 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like ATP-synt_Z PF16594.5 KOO26862.1 - 0.049 13.1 0.6 0.2 11.2 0.6 2.1 1 0 0 1 1 1 0 Putative AtpZ or ATP-synthase-associated Pkinase_fungal PF17667.1 KOO26862.1 - 0.077 11.8 0.0 0.15 10.8 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase PCI PF01399.27 KOO26863.1 - 3.6e-15 56.4 0.0 7.4e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 PCI domain Fmp27_WPPW PF10359.9 KOO26863.1 - 0.13 11.1 0.1 0.18 10.6 0.1 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain PIF1 PF05970.14 KOO26864.1 - 3e-26 92.4 0.1 2.9e-24 85.9 0.1 2.8 3 0 0 3 3 3 1 PIF1-like helicase AAA_30 PF13604.6 KOO26864.1 - 8.9e-20 71.2 3.9 1.9e-13 50.6 0.5 3.4 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KOO26864.1 - 9.1e-12 45.5 0.1 3e-11 43.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain RRM_3 PF08777.11 KOO26864.1 - 1.2e-07 31.7 0.0 3.3e-07 30.3 0.0 1.7 2 0 0 2 2 1 1 RNA binding motif AAA_22 PF13401.6 KOO26864.1 - 1.9e-05 25.0 0.0 6e-05 23.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain RRM_1 PF00076.22 KOO26864.1 - 0.00017 21.3 0.0 0.00038 20.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mg_chelatase PF01078.21 KOO26864.1 - 0.00025 20.5 0.1 0.00047 19.6 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOO26864.1 - 0.0016 18.5 0.0 0.0085 16.1 0.0 2.3 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) UvrD-helicase PF00580.21 KOO26864.1 - 0.0032 17.1 0.2 0.0069 16.0 0.1 1.5 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain SH3_13 PF18335.1 KOO26864.1 - 0.0068 16.2 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent RecD-like DNA helicase SH3 domain AAA_16 PF13191.6 KOO26864.1 - 0.016 15.6 3.4 0.025 14.9 0.1 2.6 2 1 0 2 2 2 0 AAA ATPase domain Helicase_RecD PF05127.14 KOO26864.1 - 0.031 14.1 3.7 0.14 12.0 2.1 2.5 2 1 0 2 2 2 0 Helicase AAA_14 PF13173.6 KOO26864.1 - 0.049 13.7 0.1 0.28 11.2 0.1 2.1 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KOO26864.1 - 0.08 12.9 2.1 0.56 10.1 0.6 2.7 2 1 0 2 2 2 0 NTPase DEAD PF00270.29 KOO26864.1 - 0.11 12.3 0.1 6.9 6.4 0.1 2.3 1 1 1 2 2 2 0 DEAD/DEAH box helicase Viral_helicase1 PF01443.18 KOO26864.1 - 0.11 12.2 0.4 0.7 9.6 0.4 2.1 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase LPD7 PF18821.1 KOO26864.1 - 0.12 12.6 0.2 0.44 10.7 0.0 2.1 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 7 NACHT PF05729.12 KOO26864.1 - 0.12 12.3 0.1 0.26 11.2 0.1 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 KOO26864.1 - 0.14 12.5 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase T2SSE PF00437.20 KOO26864.1 - 0.15 11.1 1.2 0.21 10.6 0.0 1.9 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_24 PF13479.6 KOO26864.1 - 0.21 11.3 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOO26864.1 - 0.36 10.6 1.6 0.59 9.9 0.0 2.2 3 0 0 3 3 2 0 AAA domain DUF4965 PF16335.5 KOO26865.1 - 5e-58 195.6 0.1 1.2e-57 194.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF5127 PF17168.4 KOO26865.1 - 6.2e-45 153.7 0.1 8.8e-45 153.2 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF1793 PF08760.11 KOO26865.1 - 6.4e-42 143.8 0.2 1.2e-41 143.0 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 KOO26865.1 - 1.3e-14 53.5 0.0 3.8e-14 52.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) PAN_4 PF14295.6 KOO26865.1 - 0.0096 15.8 2.4 0.027 14.4 2.4 1.8 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 KOO26865.1 - 0.019 14.9 1.6 0.06 13.3 1.6 1.8 1 0 0 1 1 1 0 PAN domain PAN_2 PF08276.11 KOO26865.1 - 2.9 8.1 6.4 1.3 9.1 3.1 2.1 2 0 0 2 2 2 0 PAN-like domain Peptidase_M50B PF13398.6 KOO26866.1 - 0.035 13.7 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like Lipocalin_2 PF08212.12 KOO26867.1 - 2e-08 34.3 0.0 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 Lipocalin-like domain Lipocalin PF00061.23 KOO26867.1 - 0.12 12.6 0.0 0.51 10.5 0.0 1.9 2 0 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family FGGY_N PF00370.21 KOO26868.1 - 1.2e-17 64.4 0.0 2.5e-14 53.5 0.0 2.6 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 KOO26868.1 - 1.9e-16 60.4 1.8 3e-16 59.8 0.7 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain LRR_4 PF12799.7 KOO26870.1 - 1.2e-05 25.6 0.5 5 7.7 0.0 6.4 6 0 0 6 6 6 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO26870.1 - 1.3e-05 24.8 32.5 0.00087 19.2 0.0 10.5 12 0 0 12 12 12 1 Leucine Rich repeat LRR_1 PF00560.33 KOO26870.1 - 0.00011 22.3 3.5 67 4.6 0.0 6.5 6 0 0 6 6 6 0 Leucine Rich Repeat TrkA_C PF02080.21 KOO26870.1 - 0.0012 18.7 0.0 6.4 6.7 0.0 4.6 4 0 0 4 4 4 1 TrkA-C domain PhoH PF02562.16 KOO26870.1 - 0.0077 15.7 0.1 14 5.1 0.0 4.0 4 0 0 4 4 4 1 PhoH-like protein THF_DHG_CYH_C PF02882.19 KOO26870.1 - 0.012 14.9 0.1 1.4 8.2 0.0 2.9 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SpoU_sub_bind PF08032.12 KOO26870.1 - 0.062 13.6 3.5 37 4.7 0.0 4.7 5 1 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding SLT_L PF14718.6 KOO26870.1 - 0.071 13.3 0.0 89 3.3 0.0 3.9 4 0 0 4 4 4 0 Soluble lytic murein transglycosylase L domain UPF0181 PF03701.14 KOO26870.1 - 0.078 12.6 7.9 45 3.8 0.1 5.6 6 0 0 6 6 6 0 Uncharacterised protein family (UPF0181) DUF1942 PF09167.11 KOO26870.1 - 0.13 12.3 1.2 38 4.3 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1942) PfkB PF00294.24 KOO26873.1 - 8.1e-56 189.5 0.2 1e-55 189.2 0.2 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF4057 PF13266.6 KOO26875.1 - 7.7 6.1 6.3 83 2.7 0.0 4.3 5 2 1 6 6 6 0 Protein of unknown function (DUF4057) PCMT PF01135.19 KOO26876.1 - 3.8e-28 98.7 0.0 6.6e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ank_2 PF12796.7 KOO26876.1 - 2.8e-20 72.7 4.3 3.8e-13 49.8 0.8 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO26876.1 - 2.7e-16 59.7 2.6 3.2e-08 33.9 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO26876.1 - 1.3e-15 57.1 8.8 0.00053 20.3 0.2 5.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO26876.1 - 3e-12 46.5 9.6 0.00027 21.2 0.5 4.8 2 1 3 5 5 5 3 Ankyrin repeats (many copies) SH3_15 PF18346.1 KOO26876.1 - 9.2e-10 38.7 1.2 2.6e-09 37.3 1.2 1.8 1 0 0 1 1 1 1 Mind bomb SH3 repeat domain Ank_3 PF13606.6 KOO26876.1 - 9.4e-10 37.9 4.2 1.7 9.4 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat TIR_2 PF13676.6 KOO26876.1 - 1.4e-08 35.4 0.0 4.1e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 TIR domain Methyltransf_31 PF13847.6 KOO26876.1 - 3.3e-08 33.5 0.0 9e-08 32.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain C1_2 PF03107.16 KOO26876.1 - 1.7e-07 31.5 10.6 2.9e-07 30.7 10.6 1.4 1 0 0 1 1 1 1 C1 domain Methyltransf_25 PF13649.6 KOO26876.1 - 0.00027 21.6 0.0 0.0012 19.5 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOO26876.1 - 0.0012 18.8 0.3 0.0053 16.8 0.3 2.1 1 1 0 1 1 1 1 Methyltransferase domain FYVE PF01363.21 KOO26876.1 - 0.0035 17.5 2.1 0.0076 16.4 2.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger HC2 PF07382.11 KOO26876.1 - 0.0096 16.0 13.5 0.019 15.1 13.5 1.4 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 DOT1 PF08123.13 KOO26876.1 - 0.052 13.1 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.14 KOO26876.1 - 0.13 11.8 0.0 0.13 11.8 0.0 1.9 3 0 0 3 3 2 0 Methyltransferase small domain Hc1 PF07432.13 KOO26876.1 - 0.26 11.7 11.8 0.52 10.7 11.8 1.5 1 0 0 1 1 1 0 Histone H1-like protein Hc1 zf-RING_2 PF13639.6 KOO26876.1 - 1.9 8.9 5.6 9 6.7 4.1 2.4 2 0 0 2 2 2 0 Ring finger domain DUF1682 PF07946.14 KOO26876.1 - 4.5 6.4 5.2 7.4 5.7 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SIR2 PF02146.17 KOO26878.1 - 4.7e-32 111.3 0.0 4.5e-22 78.8 0.0 2.1 2 0 0 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 KOO26878.1 - 0.018 14.8 0.2 1.8 8.3 0.0 2.7 4 0 0 4 4 4 0 Thiamine pyrophosphate enzyme, central domain Zn-ribbon_8 PF09723.10 KOO26878.1 - 0.12 12.5 0.6 0.29 11.3 0.6 1.6 1 0 0 1 1 1 0 Zinc ribbon domain zf-TFIIB PF13453.6 KOO26878.1 - 0.22 10.9 2.2 0.61 9.5 2.2 1.8 1 1 0 1 1 1 0 Transcription factor zinc-finger Peptidase_C2 PF00648.21 KOO26879.1 - 1.9e-13 50.1 0.0 3.3e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease ADK PF00406.22 KOO26880.1 - 2e-54 183.8 0.0 2.4e-54 183.5 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO26880.1 - 9.6e-28 97.3 0.2 2.1e-27 96.2 0.0 1.5 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 KOO26880.1 - 3e-15 55.9 0.0 6.4e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 KOO26880.1 - 2.5e-05 24.7 1.0 0.0046 17.2 0.1 2.5 2 1 1 3 3 3 2 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 KOO26880.1 - 7.5e-05 23.3 0.0 0.00015 22.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO26880.1 - 0.0016 18.6 0.0 0.0029 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 KOO26880.1 - 0.011 15.5 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 KOO26880.1 - 0.084 13.3 0.1 0.14 12.6 0.1 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KOO26880.1 - 0.19 11.1 0.4 0.26 10.6 0.4 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Kelch_6 PF13964.6 KOO26881.1 - 5.4e-06 26.5 0.0 14 6.2 0.0 6.1 6 0 0 6 6 6 1 Kelch motif SGL PF08450.12 KOO26881.1 - 0.00012 21.8 0.0 7.7 6.0 0.0 4.9 2 2 1 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region DUF5050 PF16472.5 KOO26881.1 - 0.22 10.7 0.0 88 2.2 0.0 4.3 7 0 0 7 7 7 0 Domain of unknown function (DUF5050) CH PF00307.31 KOO26882.1 - 3.5e-26 91.5 0.0 8.8e-13 48.4 0.1 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain EF-hand_1 PF00036.32 KOO26882.1 - 1.9e-14 52.0 0.8 2.8e-06 26.5 0.3 3.0 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO26882.1 - 6.5e-11 42.5 0.1 4.9e-10 39.7 0.0 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO26882.1 - 1.7e-10 39.9 1.8 3.1e-05 23.3 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO26882.1 - 3.6e-09 35.8 0.2 0.0045 16.8 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO26882.1 - 1.6e-08 34.3 0.4 5.3e-07 29.4 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO26882.1 - 0.024 15.0 0.1 0.14 12.4 0.0 2.4 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region OmpA PF00691.20 KOO26882.1 - 0.04 14.3 0.0 0.23 11.9 0.0 2.3 1 1 0 1 1 1 0 OmpA family EF-hand_4 PF12763.7 KOO26882.1 - 0.047 13.6 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO26882.1 - 0.064 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain tRNA_NucTransf2 PF09249.11 KOO26882.1 - 0.12 12.7 0.0 2.8 8.2 0.0 2.7 2 0 0 2 2 2 0 tRNA nucleotidyltransferase, second domain PG_isomerase_N PF18353.1 KOO26883.1 - 0.083 13.3 0.0 0.1 13.0 0.0 1.0 1 0 0 1 1 1 0 Phosphoglucose isomerase N-terminal domain p450 PF00067.22 KOO26884.1 - 0.085 11.6 0.1 0.13 11.0 0.1 1.1 1 0 0 1 1 1 0 Cytochrome P450 adh_short_C2 PF13561.6 KOO26885.1 - 1.3e-28 100.1 0.1 1.8e-28 99.7 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO26885.1 - 1e-10 41.4 0.0 1.4e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Sulfatase PF00884.23 KOO26886.1 - 2.7e-30 105.8 0.1 4.5e-30 105.1 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Ricin_B_lectin PF00652.22 KOO26886.1 - 0.0011 19.2 1.3 0.036 14.3 0.2 2.7 3 0 0 3 3 3 1 Ricin-type beta-trefoil lectin domain DUF229 PF02995.17 KOO26886.1 - 0.068 11.8 0.0 0.097 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) FSA_C PF10479.9 KOO26886.1 - 1.1 7.4 3.2 1.5 6.9 3.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus EAGR_box PF16713.5 KOO26886.1 - 9.9 5.9 9.4 0.29 10.8 2.7 1.9 2 0 0 2 2 2 0 Enriched in aromatic and glycine Residues box EF-hand_6 PF13405.6 KOO26887.1 - 5.9e-37 122.4 0.1 8.2e-07 28.5 0.0 7.4 7 0 0 7 7 7 7 EF-hand domain EF-hand_1 PF00036.32 KOO26887.1 - 5.2e-36 119.5 0.8 6.8e-07 28.4 0.0 7.4 7 0 0 7 7 7 7 EF hand EF-hand_7 PF13499.6 KOO26887.1 - 3.1e-31 107.6 8.6 4.1e-11 43.2 0.1 6.1 3 2 5 8 8 8 8 EF-hand domain pair EF-hand_8 PF13833.6 KOO26887.1 - 1.6e-17 63.1 2.7 1.6e-06 27.9 0.1 6.2 4 2 2 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO26887.1 - 3.1e-14 51.7 4.1 0.00027 20.3 0.1 5.8 7 0 0 7 7 7 3 EF hand EF-hand_11 PF08976.11 KOO26887.1 - 6e-09 36.7 0.0 0.002 19.0 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO26887.1 - 0.008 16.5 0.1 9.7 6.6 0.0 4.1 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region FKBP_C PF00254.28 KOO26888.1 - 8.6e-22 77.3 0.0 1.5e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Ank_2 PF12796.7 KOO26889.1 - 9.1e-44 148.0 13.2 1.5e-13 51.1 0.2 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Pkinase PF00069.25 KOO26889.1 - 6e-29 101.2 0.0 1.1e-28 100.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 KOO26889.1 - 2.3e-26 91.8 2.4 3.2e-08 34.0 0.1 4.9 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 KOO26889.1 - 5.3e-24 84.9 0.0 1e-23 84.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 KOO26889.1 - 1.7e-20 72.8 7.4 5.3e-07 29.8 0.2 4.9 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KOO26889.1 - 4e-15 55.5 17.6 0.00089 19.6 0.1 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 KOO26889.1 - 2.8e-14 51.8 3.8 0.044 14.3 0.0 6.4 6 0 0 6 6 6 4 Ankyrin repeat SR1P PF13790.6 KOO26889.1 - 4e-05 23.6 1.6 20 5.4 0.0 5.1 5 0 0 5 5 5 0 SR1 protein Prok-RING_1 PF14446.6 KOO26889.1 - 1.9 8.4 10.1 18 5.4 0.1 3.9 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 Ank_2 PF12796.7 KOO26890.1 - 4.1e-18 65.7 0.0 1.8e-09 38.1 0.0 1.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO26890.1 - 1e-12 48.0 0.1 4.3e-07 30.1 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO26890.1 - 1.9e-09 37.9 0.0 2.6e-08 34.2 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO26890.1 - 6.4e-07 29.2 0.0 0.052 14.1 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KOO26890.1 - 0.0004 20.7 0.5 1.1 9.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat 2OG-FeII_Oxy_3 PF13640.6 KOO26891.1 - 2.3e-17 63.7 0.2 4e-17 62.9 0.2 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO26891.1 - 9.4e-14 51.7 23.0 1.3e-06 28.9 8.2 2.7 2 0 0 2 2 2 2 ShK domain-like zf-CCCH PF00642.24 KOO26891.1 - 0.038 13.9 1.1 6.5 6.8 0.1 3.1 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ank_2 PF12796.7 KOO26892.1 - 4.2e-80 264.4 36.2 2.2e-13 50.6 0.2 6.3 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO26892.1 - 2.3e-35 120.5 13.3 1.8e-05 25.2 0.1 7.9 3 1 6 9 9 9 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO26892.1 - 1.1e-29 102.1 24.4 7e-05 23.0 0.4 9.1 1 1 9 10 10 10 10 Ankyrin repeats (many copies) Ank PF00023.30 KOO26892.1 - 1.1e-27 95.3 50.0 0.0025 18.2 0.2 12.1 13 0 0 13 13 13 9 Ankyrin repeat Ank_3 PF13606.6 KOO26892.1 - 3.1e-19 67.0 16.7 0.083 13.5 0.1 10.3 10 0 0 10 10 10 5 Ankyrin repeat Ion_trans_2 PF07885.16 KOO26892.1 - 0.00023 21.0 0.2 0.00038 20.4 0.2 1.4 1 0 0 1 1 1 1 Ion channel EF-hand_1 PF00036.32 KOO26892.1 - 0.0068 15.9 0.0 0.024 14.1 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO26892.1 - 0.0091 15.8 0.1 0.021 14.6 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO26892.1 - 0.016 15.1 0.0 0.044 13.7 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 KOO26892.1 - 0.028 14.9 0.0 0.066 13.7 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair IQ PF00612.27 KOO26892.1 - 0.098 12.5 0.1 0.3 11.0 0.1 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif EF-hand_5 PF13202.6 KOO26892.1 - 0.11 12.1 0.7 0.34 10.5 0.0 2.4 2 0 0 2 2 2 0 EF hand Prok-RING_1 PF14446.6 KOO26892.1 - 0.11 12.4 5.1 34 4.5 0.0 4.5 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 EF-hand_1 PF00036.32 KOO26893.1 - 2.2e-16 58.1 2.3 4.4e-07 29.0 0.1 2.5 2 0 0 2 2 2 2 EF hand Ion_trans PF00520.31 KOO26893.1 - 1.5e-15 57.1 8.8 4.5e-15 55.6 9.3 1.5 2 0 0 2 2 2 1 Ion transport protein EF-hand_8 PF13833.6 KOO26893.1 - 1.7e-13 50.2 1.3 7.7e-13 48.1 0.3 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO26893.1 - 4.1e-13 48.1 1.0 6.9e-07 28.7 0.1 3.0 1 1 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO26893.1 - 2.7e-12 46.9 1.3 3.3e-12 46.7 0.2 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO26893.1 - 6.9e-08 31.6 4.9 6.7e-05 22.2 0.1 2.6 2 1 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO26893.1 - 7e-06 26.3 0.2 6.4e-05 23.2 0.1 2.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_4 PF12763.7 KOO26893.1 - 2.6e-05 24.1 0.1 4.4e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO26893.1 - 0.025 14.9 0.1 0.036 14.4 0.1 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.12 KOO26893.1 - 0.086 13.0 0.2 0.11 12.6 0.2 1.2 1 0 0 1 1 1 0 p25-alpha MecA_N PF05223.11 KOO26893.1 - 0.092 13.0 0.2 0.14 12.4 0.2 1.2 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain EF-hand_11 PF08976.11 KOO26893.1 - 0.18 12.7 0.1 0.42 11.5 0.0 1.6 2 0 0 2 2 2 0 EF-hand domain TMEM65 PF10507.9 KOO26894.1 - 3.9e-39 133.0 2.1 5.2e-39 132.6 1.0 1.8 2 0 0 2 2 2 1 Transmembrane protein 65 cNMP_binding PF00027.29 KOO26894.1 - 1.1e-06 28.6 0.0 3.4e-06 27.0 0.0 1.8 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain Popeye PF04831.13 KOO26894.1 - 0.0042 17.3 0.0 0.0052 17.0 0.0 1.3 1 0 0 1 1 1 1 Popeye protein conserved region AAA_16 PF13191.6 KOO26895.1 - 3.2e-05 24.4 5.9 9.8e-05 22.8 0.2 3.8 3 1 0 4 4 4 1 AAA ATPase domain NACHT PF05729.12 KOO26895.1 - 6.1e-05 23.0 0.1 0.00012 22.1 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 KOO26895.1 - 8.2e-05 22.9 0.1 0.00034 20.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 KOO26895.1 - 0.00084 19.3 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea CHAT PF12770.7 KOO26895.1 - 0.0011 18.4 1.4 0.0029 17.0 1.4 1.8 1 1 0 1 1 1 1 CHAT domain AAA_30 PF13604.6 KOO26895.1 - 0.024 14.3 0.0 0.073 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 KOO26895.1 - 0.082 13.3 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TPR_14 PF13428.6 KOO26895.1 - 0.3 12.0 5.1 0.23 12.4 1.6 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_16 PF13191.6 KOO26896.1 - 2.5e-07 31.3 2.4 1.6e-06 28.7 0.6 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA PF00004.29 KOO26896.1 - 0.00013 22.4 0.0 0.00022 21.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CHAT PF12770.7 KOO26896.1 - 0.00032 20.2 0.8 0.00062 19.3 0.2 1.7 2 0 0 2 2 2 1 CHAT domain NB-ARC PF00931.22 KOO26896.1 - 0.00053 19.2 0.0 0.0011 18.3 0.0 1.4 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 KOO26896.1 - 0.00075 19.8 0.0 0.0026 18.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 KOO26896.1 - 0.019 14.4 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 KOO26896.1 - 0.021 14.4 0.1 0.064 12.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOO26896.1 - 0.081 12.6 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 KOO26896.1 - 0.09 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KOO26896.1 - 0.12 12.9 0.0 0.21 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain APH PF01636.23 KOO26897.1 - 1.8e-18 67.4 0.4 3.9e-18 66.2 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Polyketide_cyc2 PF10604.9 KOO26898.1 - 0.03 14.6 0.0 0.052 13.8 0.0 1.4 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Exostosin PF03016.15 KOO26899.1 - 2.5e-26 92.6 0.0 4.1e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Exostosin family DUF4334 PF14232.6 KOO26899.1 - 0.055 13.5 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4334) Abhydrolase_3 PF07859.13 KOO26900.1 - 3.8e-12 46.5 0.0 6.9e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO26900.1 - 0.0019 17.5 0.0 0.0099 15.2 0.0 1.9 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOO26900.1 - 0.16 11.5 0.0 0.34 10.4 0.0 1.5 1 1 0 1 1 1 0 Prolyl oligopeptidase family PH PF00169.29 KOO26901.1 - 1.8e-08 34.8 0.3 8.3e-08 32.7 0.3 2.0 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 KOO26901.1 - 0.0032 17.9 2.1 0.76 10.2 0.3 2.7 2 1 1 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 KOO26901.1 - 0.004 17.4 0.0 0.0084 16.4 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain V-SNARE_C PF12352.8 KOO26901.1 - 0.0081 16.4 2.0 0.017 15.4 2.0 1.5 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus PH_13 PF16652.5 KOO26901.1 - 0.14 12.0 0.2 2.8 7.7 0.0 2.7 3 0 0 3 3 3 0 Pleckstrin homology domain DUF16 PF01519.16 KOO26901.1 - 0.43 11.1 5.8 1.1 9.8 5.8 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 Mut7-C PF01927.16 KOO26902.1 - 3.6e-09 36.9 0.0 2e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 Mut7-C RNAse domain Arm PF00514.23 KOO26903.1 - 1.9e-59 196.0 17.0 3e-05 23.9 0.1 10.4 10 0 0 10 10 10 10 Armadillo/beta-catenin-like repeat SIR2 PF02146.17 KOO26903.1 - 9.6e-32 110.3 0.0 2.3e-27 96.0 0.0 2.3 1 1 1 2 2 2 2 Sir2 family Arm_2 PF04826.13 KOO26903.1 - 4.7e-07 29.5 3.0 0.68 9.3 0.0 4.9 1 1 4 5 5 5 3 Armadillo-like KOW PF00467.29 KOO26903.1 - 2e-06 27.5 7.0 79 3.4 0.0 9.4 10 0 0 10 10 10 0 KOW motif HEAT_EZ PF13513.6 KOO26903.1 - 0.0003 21.2 29.2 0.85 10.2 0.4 6.3 1 1 6 8 8 8 5 HEAT-like repeat ART PF01129.18 KOO26903.1 - 0.055 12.8 0.0 0.084 12.2 0.0 1.2 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase HEV_ORF1 PF02444.16 KOO26903.1 - 0.11 13.1 2.1 0.21 12.2 2.1 1.5 1 0 0 1 1 1 0 Hepatitis E virus ORF-2 (Putative capsid protein) ASFV_p27 PF06556.11 KOO26903.1 - 0.21 11.7 0.0 1.9e+02 2.1 0.0 4.5 4 1 1 5 5 5 0 IAP-like protein p27 C-terminus Alkyl_sulf_dimr PF14863.6 KOO26903.1 - 1.9 8.9 10.5 14 6.2 0.3 4.3 2 1 2 4 4 4 0 Alkyl sulfatase dimerisation Clathrin PF00637.20 KOO26905.1 - 1.6e-08 34.5 14.6 0.0068 16.3 0.1 7.1 6 1 2 8 8 8 2 Region in Clathrin and VPS TPR_14 PF13428.6 KOO26905.1 - 0.00025 21.6 30.0 2.1 9.4 0.1 10.6 10 1 1 11 11 10 2 Tetratricopeptide repeat PPR_2 PF13041.6 KOO26905.1 - 0.0017 18.5 0.7 0.17 12.1 0.0 4.2 4 0 0 4 4 4 1 PPR repeat family ANAPC4_WD40 PF12894.7 KOO26905.1 - 0.003 17.8 0.2 10 6.5 0.0 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nic96 PF04097.14 KOO26905.1 - 0.0042 15.6 8.3 1 7.7 0.0 4.4 3 1 3 6 6 6 2 Nup93/Nic96 TPR_7 PF13176.6 KOO26905.1 - 0.0058 16.6 20.5 18 5.7 0.1 8.3 7 1 1 8 8 8 0 Tetratricopeptide repeat WD40 PF00400.32 KOO26905.1 - 0.017 15.9 1.8 13 6.9 0.0 4.3 4 0 0 4 4 3 0 WD domain, G-beta repeat AAA_lid_5 PF17865.1 KOO26905.1 - 0.021 14.9 0.0 0.071 13.2 0.0 2.0 1 0 0 1 1 1 0 Midasin AAA lid domain Coatomer_WDAD PF04053.14 KOO26905.1 - 0.029 13.4 9.6 2 7.4 0.0 4.3 4 1 1 5 5 5 0 Coatomer WD associated region TAL_FSA PF00923.19 KOO26905.1 - 0.12 11.7 0.3 0.72 9.1 0.0 2.3 3 0 0 3 3 3 0 Transaldolase/Fructose-6-phosphate aldolase SNAP PF14938.6 KOO26905.1 - 0.16 11.4 32.9 1.1 8.6 0.1 4.9 2 2 2 4 4 4 0 Soluble NSF attachment protein, SNAP LPD22 PF18834.1 KOO26905.1 - 0.5 10.6 6.0 7.8 6.8 0.0 3.7 2 1 0 3 3 3 0 Large polyvalent protein associated domain 22 ANAPC3 PF12895.7 KOO26905.1 - 0.51 10.6 34.9 1.4 9.2 0.3 9.2 6 2 5 11 11 11 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KOO26905.1 - 5.8 7.4 11.2 47 4.6 0.3 6.0 7 0 0 7 7 6 0 Tetratricopeptide repeat MIT PF04212.18 KOO26905.1 - 6.3 7.0 20.7 1.4 9.0 0.4 5.6 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain DUF641 PF04859.12 KOO26907.1 - 0.053 13.9 1.8 0.078 13.3 1.8 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) GAS PF13851.6 KOO26907.1 - 0.12 11.7 6.4 0.16 11.3 6.4 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DASH_Spc34 PF08657.10 KOO26907.1 - 0.25 11.1 4.3 0.3 10.8 4.3 1.1 1 0 0 1 1 1 0 DASH complex subunit Spc34 PKcGMP_CC PF16808.5 KOO26907.1 - 0.57 10.1 10.6 0.99 9.3 0.1 2.8 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Spc7 PF08317.11 KOO26907.1 - 1.3 7.8 7.3 1.7 7.4 7.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Bap31_Bap29_C PF18035.1 KOO26907.1 - 2.2 8.3 6.5 2.3 8.3 0.3 2.5 3 0 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Fib_alpha PF08702.10 KOO26907.1 - 2.3 8.4 5.8 4.6 7.4 1.4 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Csm1_N PF18504.1 KOO26907.1 - 2.3 8.6 9.3 5.2 7.5 3.1 2.5 2 1 0 2 2 2 0 Csm1 N-terminal domain DivIC PF04977.15 KOO26907.1 - 7.4 6.4 12.2 46 3.9 0.4 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF1517 PF07466.11 KOO26908.1 - 1.9e-26 93.3 0.0 2.2e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1517) Aha1_N PF09229.11 KOO26909.1 - 4.3e-12 46.4 0.0 6.4e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal Ank_2 PF12796.7 KOO26910.1 - 8.5e-15 55.1 4.1 2.5e-11 44.0 1.5 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO26910.1 - 2.3e-11 43.6 1.8 0.0013 19.1 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 KOO26910.1 - 1.2e-07 31.5 0.3 0.0057 17.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 KOO26910.1 - 4.2e-06 27.2 0.8 0.024 15.2 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO26910.1 - 4.5e-05 23.6 1.4 0.0026 18.0 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Lipase_3 PF01764.25 KOO26911.1 - 1.2e-09 38.2 0.0 3.1e-09 36.8 0.0 1.7 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_3 PF07859.13 KOO26911.1 - 0.014 15.3 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOO26911.1 - 1.8 9.1 13.2 0.077 13.6 6.9 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family LRR_8 PF13855.6 KOO26912.1 - 4.8e-13 48.7 4.0 0.00012 21.8 0.0 5.0 3 2 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 KOO26912.1 - 0.00014 22.2 1.8 1.4 9.4 0.1 4.6 4 1 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO26912.1 - 0.0013 19.0 3.6 2e+02 3.2 0.0 7.1 9 0 0 9 9 9 0 Leucine Rich Repeat Shisa PF13908.6 KOO26912.1 - 0.17 12.1 1.5 0.3 11.3 1.5 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator EF-hand_1 PF00036.32 KOO26914.1 - 1.2e-12 46.4 0.2 1.3e-05 24.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO26914.1 - 3.2e-12 45.3 0.4 6.1e-05 22.6 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO26914.1 - 8.9e-11 40.8 1.0 0.00023 20.5 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO26914.1 - 3.6e-09 36.9 0.0 1.4e-08 35.1 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO26914.1 - 3.1e-06 26.9 0.0 0.034 14.0 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO26914.1 - 0.047 14.0 0.0 0.26 11.6 0.0 2.3 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Asp-B-Hydro_N PF05279.11 KOO26914.1 - 5.4 7.0 26.3 12 5.9 26.3 1.6 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region ELFV_dehydrog_N PF02812.18 KOO26916.1 - 0.026 14.4 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain GSH-S_ATP PF02955.16 KOO26916.1 - 0.15 11.4 0.0 0.32 10.4 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain Pkinase PF00069.25 KOO26917.1 - 4.7e-47 160.6 0.0 1.4e-46 159.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO26917.1 - 1e-28 99.2 0.1 5e-14 52.1 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO26917.1 - 6.5e-25 87.9 0.0 1.1e-24 87.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 KOO26917.1 - 2.5e-07 31.0 0.0 7.9e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain APH PF01636.23 KOO26917.1 - 0.00097 19.1 0.6 1.1 9.1 0.0 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family eIF3_subunit PF08597.10 KOO26918.1 - 7.8e-30 104.6 21.9 1.2e-29 103.9 21.9 1.3 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit VIT1 PF01988.19 KOO26918.1 - 6.6 6.5 5.3 15 5.3 1.7 2.1 2 0 0 2 2 2 0 VIT family WD40 PF00400.32 KOO26919.1 - 4.4e-26 90.6 4.2 3.3e-07 30.9 0.2 6.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO26919.1 - 8.1e-10 38.9 0.0 0.057 13.7 0.0 4.4 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO26919.1 - 0.00045 19.3 0.3 0.18 10.7 0.0 2.9 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KOO26919.1 - 0.0029 16.3 1.7 0.49 9.0 0.1 3.0 2 1 0 2 2 2 2 Nucleoporin Nup120/160 ADK PF00406.22 KOO26920.1 - 5.6e-52 175.8 0.0 6.8e-52 175.6 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO26920.1 - 1.1e-23 84.2 0.1 2.2e-23 83.2 0.0 1.5 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 KOO26920.1 - 1.5e-14 53.6 0.0 2.9e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 KOO26920.1 - 2.7e-05 24.5 0.6 0.003 17.9 0.1 2.3 1 1 1 2 2 2 1 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 KOO26920.1 - 0.00064 20.3 0.0 0.0016 19.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO26920.1 - 0.0016 18.6 0.0 0.003 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 KOO26920.1 - 0.023 14.4 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase Zeta_toxin PF06414.12 KOO26920.1 - 0.096 12.0 0.1 0.21 10.9 0.1 1.6 1 1 0 1 1 1 0 Zeta toxin AAA PF00004.29 KOO26920.1 - 0.19 12.2 0.1 0.34 11.3 0.1 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Hira PF07569.11 KOO26923.1 - 8.2e-14 51.9 0.0 1.1e-13 51.5 0.0 1.1 1 0 0 1 1 1 1 TUP1-like enhancer of split NHL PF01436.21 KOO26925.1 - 1.4e-23 81.6 3.9 2.3e-08 33.6 0.0 6.3 7 0 0 7 7 7 4 NHL repeat DUF5128 PF17170.4 KOO26925.1 - 1.6e-05 24.2 0.0 0.002 17.3 0.1 3.0 2 1 1 3 3 3 2 6-bladed beta-propeller TolB_like PF15869.5 KOO26925.1 - 0.00062 19.1 0.0 0.0033 16.7 0.0 2.0 2 0 0 2 2 2 1 TolB-like 6-blade propeller-like SGL PF08450.12 KOO26925.1 - 0.0091 15.6 0.0 1.1 8.8 0.0 2.5 3 0 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 KOO26925.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Esterase-like activity of phytase DUF3638 PF12340.8 KOO26926.1 - 1.8e-23 83.1 0.0 6.9e-22 77.9 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO26926.1 - 1.3e-14 53.3 0.4 2.7e-14 52.2 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) PDZ_6 PF17820.1 KOO26926.1 - 6.8e-06 25.8 0.2 2.6e-05 24.0 0.2 2.0 1 0 0 1 1 1 1 PDZ domain Vps62 PF06101.11 KOO26926.1 - 0.0028 16.0 0.0 0.0048 15.3 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 PDZ PF00595.24 KOO26926.1 - 0.0042 17.4 0.0 0.0097 16.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO26926.1 - 0.0044 17.3 0.0 0.015 15.6 0.0 1.9 2 0 0 2 2 2 1 PDZ domain EF-hand_7 PF13499.6 KOO26926.1 - 0.0075 16.7 0.3 0.055 13.9 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO26926.1 - 0.012 15.1 1.1 0.029 13.9 0.2 2.1 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.32 KOO26926.1 - 0.013 15.0 0.1 0.086 12.4 0.0 2.3 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 KOO26926.1 - 0.061 13.2 0.1 0.21 11.4 0.1 1.9 1 0 0 1 1 1 0 EF-hand domain pair OPT PF03169.15 KOO26927.1 - 5.3e-125 418.4 34.8 6e-125 418.2 34.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Phage_holin_2_1 PF04971.12 KOO26927.1 - 2.3 8.3 7.4 1.5 8.9 0.3 3.6 3 0 0 3 3 3 0 Bacteriophage P21 holin S MFS_1 PF07690.16 KOO26928.1 - 1.2e-13 50.7 18.8 1.2e-13 50.7 18.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Presenilin PF01080.17 KOO26928.1 - 0.041 12.6 0.7 0.078 11.7 0.7 1.4 1 0 0 1 1 1 0 Presenilin PAP2 PF01569.21 KOO26930.1 - 2.3e-18 66.2 5.7 2.3e-18 66.2 5.7 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KOO26930.1 - 3.8e-07 30.0 4.9 3.8e-07 30.0 4.9 2.0 2 0 0 2 2 2 1 PAP2 superfamily ORC5_C PF14630.6 KOO26931.1 - 3e-38 132.0 0.0 4.5e-38 131.4 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 KOO26931.1 - 1.9e-09 38.1 0.1 3.6e-08 34.0 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOO26931.1 - 9.4e-09 35.7 0.0 7e-08 32.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 KOO26931.1 - 0.0035 17.3 0.0 0.0058 16.6 0.0 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA PF00004.29 KOO26931.1 - 0.026 14.9 0.0 0.044 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOO26931.1 - 0.07 13.0 0.0 0.17 11.8 0.0 1.6 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 KOO26931.1 - 0.12 12.8 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 KOO26931.1 - 0.18 11.3 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 KOO26931.1 - 0.19 11.7 0.0 0.36 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) EF-hand_1 PF00036.32 KOO26932.1 - 1.9e-13 48.9 3.8 0.0027 17.2 0.2 3.4 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 KOO26932.1 - 2.5e-09 36.2 4.6 0.0081 15.6 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO26932.1 - 2.9e-09 36.1 5.1 0.021 14.7 0.2 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO26932.1 - 7.1e-09 36.0 2.4 8.3e-06 26.2 0.6 2.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO26932.1 - 2.7e-06 27.1 4.5 0.011 15.6 0.5 3.4 3 0 0 3 3 3 2 EF-hand domain pair FHA PF00498.26 KOO26936.1 - 1.6e-15 57.2 0.1 3.2e-15 56.2 0.1 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO26936.1 - 0.00056 20.2 0.0 0.0011 19.2 0.0 1.6 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Sina PF03145.16 KOO26936.1 - 0.0073 16.3 0.2 0.012 15.6 0.2 1.3 1 0 0 1 1 1 1 Seven in absentia protein family zf-CXXC PF02008.20 KOO26936.1 - 4.3 7.5 11.8 13 5.9 9.3 2.5 2 0 0 2 2 2 0 CXXC zinc finger domain SBP_bac_3 PF00497.20 KOO26937.1 - 0.5 9.7 3.2 0.48 9.8 1.4 1.8 1 1 1 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 ADIP PF11559.8 KOO26937.1 - 0.73 9.9 28.9 0.069 13.2 9.5 3.7 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 KOO26937.1 - 0.82 10.3 14.6 13 6.4 0.4 3.9 1 1 2 4 4 4 0 Initiation control protein YabA DUF1664 PF07889.12 KOO26937.1 - 0.82 9.7 8.3 8.2 6.5 1.1 3.5 2 2 4 6 6 6 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 KOO26937.1 - 0.93 9.7 39.4 1.5 9.0 14.6 3.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) GAS PF13851.6 KOO26937.1 - 1.4 8.2 22.3 0.21 10.9 0.9 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding HMMR_C PF15908.5 KOO26937.1 - 1.7 8.9 10.3 1.1 9.5 5.0 2.4 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal CENP-F_leu_zip PF10473.9 KOO26937.1 - 4.9 7.2 25.1 0.3 11.1 6.2 3.2 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PI3K_P85_iSH2 PF16454.5 KOO26937.1 - 7 6.2 12.8 0.74 9.4 7.1 2.2 2 1 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Myb_DNA-binding PF00249.31 KOO26938.1 - 7.5e-12 45.3 0.4 1.5e-11 44.3 0.0 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain ubiquitin PF00240.23 KOO26938.1 - 1e-09 38.0 0.0 1.3e-06 28.1 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin family Myb_DNA-bind_6 PF13921.6 KOO26938.1 - 0.028 14.7 0.9 0.065 13.5 0.1 1.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO26938.1 - 0.2 11.5 0.0 0.36 10.8 0.0 1.3 1 0 0 1 1 1 0 Myb DNA-binding like SlyX PF04102.12 KOO26938.1 - 1.3 9.7 7.7 0.11 13.1 0.8 2.6 3 0 0 3 3 3 0 SlyX zf-C2H2 PF00096.26 KOO26939.1 - 3.5e-19 68.1 19.3 0.00014 22.1 0.7 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO26939.1 - 2.2e-17 62.6 21.7 3.5e-08 33.5 0.3 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO26939.1 - 1.5e-14 53.4 18.4 0.0057 17.4 0.6 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KOO26939.1 - 0.0001 22.5 10.3 2.3 8.3 0.3 4.0 1 1 3 4 4 4 3 Aberrant zinc-finger FOXP-CC PF16159.5 KOO26939.1 - 0.00069 20.2 4.6 0.44 11.2 0.0 3.4 3 1 1 4 4 4 2 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 KOO26939.1 - 0.00082 19.6 9.0 0.078 13.3 0.7 4.0 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KOO26939.1 - 0.00092 19.1 16.1 0.012 15.6 0.2 4.3 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KOO26939.1 - 0.002 17.9 12.6 0.68 9.7 0.4 4.3 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-met PF12874.7 KOO26939.1 - 0.0036 17.7 4.5 0.35 11.3 0.2 3.6 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 KOO26939.1 - 0.0085 16.4 5.6 0.93 9.8 0.9 2.4 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-TRAF PF02176.18 KOO26939.1 - 0.045 14.4 8.8 1.4 9.6 1.8 3.0 1 1 2 3 3 3 0 TRAF-type zinc finger CHORD PF04968.12 KOO26939.1 - 0.074 13.8 9.0 18 6.1 0.1 4.1 1 1 3 4 4 4 0 CHORD zf-CGNR PF11706.8 KOO26939.1 - 0.2 11.6 5.0 3.7 7.5 0.5 3.7 3 1 0 3 3 3 0 CGNR zinc finger zf-C2H2_11 PF16622.5 KOO26939.1 - 0.29 10.9 9.0 0.85 9.4 0.0 3.5 4 0 0 4 4 4 0 zinc-finger C2H2-type CxC6 PF18721.1 KOO26939.1 - 2.3 8.6 6.3 7.2 7.0 3.6 2.6 1 1 1 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases CCAP PF11105.8 KOO26939.1 - 9.8 6.1 7.8 21 5.1 0.3 2.8 1 1 2 3 3 3 0 Arthropod cardioacceleratory peptide 2a TIG PF01833.24 KOO26940.1 - 1.6e-40 137.1 6.0 2.1e-07 30.9 0.0 6.6 6 1 0 6 6 6 6 IPT/TIG domain TIG_plexin PF17960.1 KOO26940.1 - 3.9e-10 39.6 0.0 0.65 10.0 0.0 6.2 6 0 0 6 6 6 3 TIG domain Glucodextran_B PF09136.10 KOO26940.1 - 0.064 13.6 3.2 0.066 13.6 0.2 2.5 2 0 0 2 2 2 0 Glucodextranase, domain B ChapFlgA_N PF17656.1 KOO26940.1 - 0.074 13.2 0.4 11 6.3 0.1 2.8 2 0 0 2 2 2 0 FlgA N-terminal domain HemY_N PF07219.13 KOO26941.1 - 0.54 10.5 5.6 1.9 8.8 5.6 1.9 1 0 0 1 1 1 0 HemY protein N-terminus HC2 PF07382.11 KOO26942.1 - 0.00032 20.9 15.2 0.00054 20.1 15.2 1.3 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 PDZ_3 PF17815.1 KOO26943.1 - 3.8e-20 72.2 0.0 6e-20 71.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Trypsin_2 PF13365.6 KOO26943.1 - 2.3e-18 67.5 1.0 4.2e-18 66.7 1.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 KOO26943.1 - 9e-08 32.2 0.2 1.9e-07 31.1 0.2 1.5 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 KOO26943.1 - 0.00028 21.1 0.0 0.0021 18.4 0.1 2.3 2 1 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KOO26943.1 - 0.00098 18.9 0.1 0.69 9.8 0.1 2.8 2 0 0 2 2 2 2 PDZ domain MIB_HERC2 PF06701.13 KOO26944.1 - 9e-17 61.1 10.7 2.5e-16 59.7 10.0 2.2 2 0 0 2 2 2 1 Mib_herc2 SH3_15 PF18346.1 KOO26944.1 - 2.4e-13 50.2 10.5 3.6e-09 36.8 0.8 4.0 3 0 0 3 3 3 2 Mind bomb SH3 repeat domain COR PF16095.5 KOO26944.1 - 2.5e-13 50.3 0.0 6e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain DUF4314 PF14192.6 KOO26944.1 - 1.3 9.0 8.3 4 7.4 4.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4314) DNA_photolyase PF00875.18 KOO26945.1 - 1.5e-13 51.1 0.0 1.1e-12 48.3 0.0 2.1 2 0 0 2 2 2 1 DNA photolyase Med26 PF08711.11 KOO26945.1 - 0.0025 17.8 0.0 0.0055 16.7 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain FAD_binding_7 PF03441.14 KOO26945.1 - 0.11 12.0 0.5 0.17 11.4 0.5 1.3 1 0 0 1 1 1 0 FAD binding domain of DNA photolyase Ank_2 PF12796.7 KOO26946.1 - 4.5e-69 229.1 33.6 2.4e-13 50.5 0.7 7.4 1 1 7 9 9 9 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO26946.1 - 4e-68 224.6 40.8 7.9e-10 38.8 0.2 11.6 3 3 9 12 12 12 12 Ankyrin repeats (many copies) Ank PF00023.30 KOO26946.1 - 4.9e-57 188.0 16.5 2e-05 24.8 0.1 12.7 13 0 0 13 13 13 12 Ankyrin repeat Ank_3 PF13606.6 KOO26946.1 - 1.1e-52 169.8 2.8 0.0083 16.6 0.0 13.2 13 0 0 13 13 13 11 Ankyrin repeat Ank_4 PF13637.6 KOO26946.1 - 2.2e-48 162.0 4.1 2e-07 31.4 0.0 10.2 6 4 5 11 11 11 10 Ankyrin repeats (many copies) Prenyltransf PF01255.19 KOO26946.1 - 3.4e-05 23.5 0.2 0.87 9.1 0.0 4.0 2 1 0 3 3 3 2 Putative undecaprenyl diphosphate synthase MAPKK1_Int PF08923.10 KOO26946.1 - 0.009 15.8 0.1 9.3 6.1 0.0 4.8 4 3 3 7 7 7 1 Mitogen-activated protein kinase kinase 1 interacting APC_15aa PF05972.11 KOO26946.1 - 0.012 15.8 0.0 0.51 10.7 0.0 2.6 2 0 0 2 2 2 0 APC 15 residue motif Beach PF02138.18 KOO26946.1 - 0.15 11.4 0.0 7.6 5.8 0.0 3.5 4 1 1 5 5 5 0 Beige/BEACH domain Ank_5 PF13857.6 KOO26947.1 - 4.2e-41 138.5 7.0 7.2e-09 35.8 0.4 8.0 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO26947.1 - 3.2e-38 130.2 15.2 1.5e-09 38.3 0.6 5.3 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.30 KOO26947.1 - 2.7e-27 94.0 5.5 0.00018 21.8 0.0 8.6 9 0 0 9 9 9 5 Ankyrin repeat Ank_3 PF13606.6 KOO26947.1 - 1.4e-24 83.5 0.1 0.031 14.8 0.0 8.8 8 0 0 8 8 8 5 Ankyrin repeat Ank_4 PF13637.6 KOO26947.1 - 3.3e-24 84.9 0.4 9.8e-06 26.0 0.0 6.7 5 1 1 6 6 6 5 Ankyrin repeats (many copies) PARP PF00644.20 KOO26947.1 - 1.1e-07 31.6 0.0 8.5e-07 28.8 0.0 2.2 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF3395 PF11875.8 KOO26947.1 - 0.0032 17.4 0.0 0.0079 16.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) SH3_3 PF08239.11 KOO26947.1 - 0.0049 17.1 0.0 0.016 15.5 0.0 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain CAP_N PF01213.19 KOO26947.1 - 2.9 7.3 9.6 22 4.4 0.0 2.3 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal GTP_EFTU PF00009.27 KOO26948.1 - 1.2e-47 162.0 0.1 2e-47 161.2 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KOO26948.1 - 1.2e-20 73.3 0.0 2.4e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 KOO26948.1 - 6e-08 32.8 0.8 1.4e-07 31.6 0.2 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.18 KOO26948.1 - 0.00013 21.3 0.1 0.00021 20.7 0.1 1.2 1 0 0 1 1 1 1 Septin EFG_II PF14492.6 KOO26948.1 - 0.0029 17.6 0.3 0.0062 16.6 0.3 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II AIG1 PF04548.16 KOO26948.1 - 0.015 14.7 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 AIG1 family FeoB_N PF02421.18 KOO26948.1 - 0.023 14.2 0.2 0.2 11.2 0.2 2.5 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 KOO26948.1 - 0.059 13.4 0.0 1.6 8.8 0.0 2.4 1 1 1 2 2 2 0 Dynamin family Roc PF08477.13 KOO26948.1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase MFS_1 PF07690.16 KOO26950.1 - 3.5e-28 98.5 57.3 5.5e-21 74.9 21.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 KOO26951.1 - 3.6e-18 65.6 15.2 6.7e-18 64.7 15.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 KOO26951.1 - 0.076 11.9 6.4 0.044 12.6 3.8 1.7 2 0 0 2 2 2 0 MFS_1 like family AAA_16 PF13191.6 KOO26951.1 - 0.46 10.9 3.7 0.26 11.7 0.3 2.3 2 0 0 2 2 2 0 AAA ATPase domain PUCC PF03209.15 KOO26951.1 - 0.63 9.0 11.7 1.3 8.0 11.7 1.4 1 0 0 1 1 1 0 PUCC protein RabGAP-TBC PF00566.18 KOO26953.1 - 2.1e-23 83.1 0.1 2.6e-23 82.8 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain YihI PF04220.12 KOO26954.1 - 0.013 15.2 0.2 0.42 10.3 0.1 2.1 2 0 0 2 2 2 0 Der GTPase activator (YihI) T2SSJ PF11612.8 KOO26955.1 - 0.043 14.0 0.1 0.67 10.2 0.0 2.5 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein J EF-hand_8 PF13833.6 KOO26956.1 - 1.1e-11 44.4 0.2 1.1e-11 44.4 0.2 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO26956.1 - 1e-08 34.1 0.2 2.3e-08 33.0 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO26956.1 - 9.3e-06 26.0 0.1 2.3e-05 24.8 0.0 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO26956.1 - 9.1e-05 22.1 0.4 0.0016 18.2 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO26956.1 - 0.0033 16.8 0.7 0.012 15.1 0.2 2.1 1 1 1 2 2 2 1 EF hand EF-hand_4 PF12763.7 KOO26956.1 - 0.04 13.9 0.0 0.083 12.9 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO26956.1 - 0.18 12.1 0.0 0.43 10.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain DHquinase_II PF01220.19 KOO26957.1 - 1.5e-45 154.3 0.0 2.6e-45 153.5 0.0 1.4 1 1 0 1 1 1 1 Dehydroquinase class II FAM176 PF14851.6 KOO26958.1 - 0.039 13.6 2.3 0.12 12.0 1.3 2.2 2 0 0 2 2 2 0 FAM176 family Pox_Ag35 PF03286.14 KOO26958.1 - 0.66 9.7 4.1 0.11 12.3 0.3 1.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF4611 PF15387.6 KOO26958.1 - 1.1 9.5 15.8 4.7 7.5 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Astro_capsid_p PF12226.8 KOO26958.1 - 2 7.5 4.3 3.4 6.7 4.3 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.12 KOO26958.1 - 2.5 6.2 7.1 4.5 5.3 7.1 1.3 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 KOO26958.1 - 4.4 6.4 4.6 1.6 7.8 1.3 1.7 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 KOO26958.1 - 10 4.3 7.4 19 3.4 7.4 1.3 1 0 0 1 1 1 0 CDC45-like protein AAA PF00004.29 KOO26959.1 - 1.7e-40 138.5 0.0 2.8e-40 137.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KOO26959.1 - 1.9e-08 34.1 0.0 4.5e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 KOO26959.1 - 6e-07 29.8 0.2 0.0023 18.2 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_lid_3 PF17862.1 KOO26959.1 - 3.4e-06 26.7 0.1 6.5e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 KOO26959.1 - 3.7e-06 27.2 0.0 7.2e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOO26959.1 - 1.4e-05 25.6 0.3 0.0014 19.0 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 KOO26959.1 - 6.6e-05 22.2 0.0 0.00013 21.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KOO26959.1 - 0.00017 21.4 0.0 0.00033 20.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KOO26959.1 - 0.00019 21.5 0.2 0.00069 19.6 0.2 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 KOO26959.1 - 0.008 16.6 0.0 0.021 15.2 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 KOO26959.1 - 0.011 15.9 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KOO26959.1 - 0.012 15.3 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 KOO26959.1 - 0.014 14.9 0.7 0.72 9.4 0.1 2.3 1 1 1 2 2 2 0 AAA domain ATPase PF06745.13 KOO26959.1 - 0.018 14.4 0.1 0.2 11.0 0.1 2.2 1 1 1 2 2 2 0 KaiC AAA_3 PF07726.11 KOO26959.1 - 0.019 14.8 0.1 0.067 13.0 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KOO26959.1 - 0.02 14.9 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 KOO26959.1 - 0.023 13.9 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Sigma54_activat PF00158.26 KOO26959.1 - 0.033 13.9 0.0 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain TsaE PF02367.17 KOO26959.1 - 0.035 14.1 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 KOO26959.1 - 0.044 13.7 0.2 0.47 10.4 0.1 2.4 2 0 0 2 2 2 0 NTPase NACHT PF05729.12 KOO26959.1 - 0.045 13.7 0.1 0.23 11.4 0.0 2.1 1 1 1 2 2 2 0 NACHT domain AAA_24 PF13479.6 KOO26959.1 - 0.057 13.1 1.1 0.13 12.0 0.2 2.0 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KOO26959.1 - 0.058 13.6 0.3 0.49 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 KOO26959.1 - 0.072 12.3 0.0 0.75 8.9 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 KOO26959.1 - 0.077 12.5 0.0 0.18 11.3 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 KOO26959.1 - 0.08 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 KOO26959.1 - 0.11 11.9 0.1 0.33 10.4 0.1 1.7 2 0 0 2 2 1 0 PhoH-like protein MCM PF00493.23 KOO26959.1 - 0.14 11.2 0.0 0.35 9.9 0.0 1.6 1 0 0 1 1 1 0 MCM P-loop domain AAA_18 PF13238.6 KOO26959.1 - 0.14 12.7 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO26959.1 - 0.15 11.2 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Inositol_P PF00459.25 KOO26960.1 - 2.3e-18 66.7 0.2 8.1e-18 64.9 0.2 1.8 1 1 0 1 1 1 1 Inositol monophosphatase family DIRP PF06584.13 KOO26961.1 - 5e-16 58.8 0.0 1.2e-15 57.6 0.0 1.7 1 0 0 1 1 1 1 DIRP UPF0047 PF01894.17 KOO26964.1 - 1.1e-29 102.9 0.0 1.4e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 DUF4457 PF14652.6 KOO26965.1 - 4.3e-37 128.1 0.0 9.4e-37 127.0 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4457) cNMP_binding PF00027.29 KOO26965.1 - 5e-21 74.6 0.1 1.5e-20 73.0 0.0 1.8 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain CRAL_TRIO PF00650.20 KOO26965.1 - 9.2e-13 48.2 0.0 1.6e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Sulfatase PF00884.23 KOO26965.1 - 3.4e-05 23.4 0.0 5.2e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 KOO26965.1 - 7.8e-05 22.4 0.1 0.00014 21.6 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase CRAL_TRIO_N PF03765.15 KOO26965.1 - 0.12 12.5 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain DnaJ_C PF01556.18 KOO26966.1 - 1.5e-33 116.0 0.0 2e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOO26966.1 - 5.1e-23 81.0 0.2 8.3e-23 80.3 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain MRP-L27 PF09809.9 KOO26966.1 - 0.03 14.1 0.1 0.059 13.2 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 DUF4457 PF14652.6 KOO26967.1 - 1.6e-27 96.6 0.0 3.6e-27 95.5 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4457) EPTP PF03736.17 KOO26969.1 - 3.3e-32 110.2 0.4 1.2e-06 28.3 0.1 6.3 6 0 0 6 6 6 5 EPTP domain Kinesin PF00225.23 KOO26969.1 - 2.3e-16 59.6 0.0 5.3e-16 58.5 0.0 1.5 2 0 0 2 2 2 1 Kinesin motor domain zf-MYND PF01753.18 KOO26969.1 - 4.2e-10 39.5 19.4 4.2e-10 39.5 19.4 2.0 2 0 0 2 2 2 1 MYND finger Microtub_bd PF16796.5 KOO26969.1 - 1.3e-05 25.2 0.0 3.4e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding TPR_10 PF13374.6 KOO26969.1 - 0.017 15.0 0.0 0.017 15.0 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat FapA PF03961.13 KOO26969.1 - 0.22 10.1 4.4 0.39 9.3 4.4 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A TFIIA PF03153.13 KOO26969.1 - 8.2 6.3 11.1 13 5.6 11.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Methyltransf_21 PF05050.12 KOO26970.1 - 4.4e-09 36.6 0.0 6.9e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain U-box PF04564.15 KOO26971.1 - 1.2e-13 51.0 0.0 2.4e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO26971.1 - 1e-06 28.4 0.0 1.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO26971.1 - 0.0023 18.0 0.0 0.0038 17.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein DUF962 PF06127.11 KOO26971.1 - 0.051 13.7 0.0 0.079 13.1 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF962) 7tm_3 PF00003.22 KOO26971.1 - 0.057 13.1 1.8 0.09 12.5 1.8 1.3 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR UPF0542 PF15086.6 KOO26971.1 - 0.15 12.0 0.3 0.56 10.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 zf-RING_UBOX PF13445.6 KOO26971.1 - 0.17 11.9 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger DUF588 PF04535.12 KOO26971.1 - 0.19 11.5 3.1 4.9 6.9 0.1 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF588) PALP PF00291.25 KOO26973.1 - 1.7e-60 204.9 0.5 2e-60 204.7 0.5 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme EF-hand_1 PF00036.32 KOO26974.1 - 5e-11 41.3 0.5 0.00013 21.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO26974.1 - 8.9e-10 38.9 0.2 1.4e-09 38.3 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO26974.1 - 1.4e-06 27.7 0.0 0.0027 17.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO26974.1 - 2.3e-05 23.7 0.1 0.0044 16.5 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 KOO26974.1 - 0.00021 21.6 0.3 0.00043 20.6 0.1 1.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 KOO26974.1 - 0.0077 16.1 2.0 0.45 10.4 0.0 2.4 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_4 PF12763.7 KOO26974.1 - 0.0079 16.1 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand PC-Esterase PF13839.6 KOO26975.1 - 1.3e-07 31.6 7.9 1.2e-05 25.2 7.9 2.4 1 1 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p BCAS2 PF05700.11 KOO26975.1 - 0.058 13.1 0.0 0.19 11.4 0.1 1.8 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) CS PF04969.16 KOO26976.1 - 3.5e-06 27.9 0.0 6.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 CS domain DUF3486 PF11985.8 KOO26976.1 - 0.13 12.7 11.6 0.29 11.5 11.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) LigB PF02900.18 KOO26976.1 - 0.2 10.7 0.1 0.33 10.0 0.1 1.3 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase KfrA_N PF11740.8 KOO26976.1 - 0.29 11.8 13.5 0.62 10.8 13.5 1.6 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term adh_short PF00106.25 KOO26977.1 - 1.7e-15 57.0 0.1 6.5e-09 35.5 0.0 3.2 3 1 1 4 4 4 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO26977.1 - 8.3e-14 51.7 0.0 2e-05 24.3 0.0 2.8 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase GLE1 PF07817.13 KOO26977.1 - 0.098 11.8 2.5 0.19 10.9 2.5 1.4 1 0 0 1 1 1 0 GLE1-like protein FdhD-NarQ PF02634.15 KOO26977.1 - 0.21 11.2 0.0 0.21 11.2 0.0 2.4 2 0 0 2 2 2 0 FdhD/NarQ family GST_C PF00043.25 KOO26978.1 - 1.8e-11 44.1 0.0 3.5e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOO26978.1 - 1.6e-06 28.4 0.0 4.7e-06 26.9 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KOO26978.1 - 2.9e-06 27.5 0.0 8.6e-06 26.0 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOO26978.1 - 4.1e-06 26.9 0.0 6.6e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOO26978.1 - 6.6e-06 26.1 0.1 2e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KOO26978.1 - 3.3e-05 24.1 0.0 6.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 KOO26978.1 - 0.0013 19.5 0.0 0.0022 18.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 KOO26978.1 - 0.13 12.1 0.0 0.32 10.8 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 KOO26978.1 - 0.17 12.2 0.0 0.33 11.3 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein DUF5422 PF17459.2 KOO26979.1 - 0.71 10.1 5.7 1.5 9.0 5.7 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5422) Pkinase PF00069.25 KOO26980.1 - 1.2e-29 103.4 0.0 1.5e-29 103.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO26980.1 - 1.2e-11 44.5 0.0 1.3e-11 44.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO26980.1 - 0.018 15.0 0.2 0.035 14.0 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family EF-hand_5 PF13202.6 KOO26981.1 - 0.054 13.0 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 KOO26981.1 - 0.18 11.6 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair GRIP PF01465.20 KOO26983.1 - 7.1e-09 35.4 4.8 0.003 17.4 2.2 3.3 2 1 0 2 2 2 2 GRIP domain DUF501 PF04417.12 KOO26983.1 - 0.0039 17.0 2.7 0.0043 16.9 0.8 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF501) HAP1_N PF04849.13 KOO26983.1 - 0.016 14.4 7.7 0.46 9.7 1.5 2.1 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Spc7 PF08317.11 KOO26983.1 - 0.24 10.3 2.8 0.11 11.4 0.3 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein SurA_N PF09312.11 KOO26983.1 - 0.26 11.4 4.0 16 5.6 0.5 2.9 2 1 1 3 3 3 0 SurA N-terminal domain Cep57_MT_bd PF06657.13 KOO26983.1 - 2.6 8.5 10.5 9.7 6.7 0.1 3.3 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Polysacc_deac_1 PF01522.21 KOO26984.1 - 1.9e-18 66.5 0.0 6.4e-18 64.8 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 KOO26984.1 - 0.00079 18.7 0.0 0.0017 17.6 0.0 1.6 1 0 0 1 1 1 1 Divergent polysaccharide deacetylase Pho88 PF10032.9 KOO26985.1 - 4e-31 107.7 0.0 6.1e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 Phosphate transport (Pho88) Herpes_ICP4_N PF03584.15 KOO26985.1 - 0.044 13.6 0.2 0.082 12.7 0.2 1.4 1 0 0 1 1 1 0 Herpesvirus ICP4-like protein N-terminal region Caps_synth PF05704.12 KOO26986.1 - 6e-10 39.0 1.1 6e-10 39.0 1.1 1.7 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 KOO26986.1 - 0.0009 19.8 0.0 0.0037 17.8 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Ion_trans PF00520.31 KOO26988.1 - 3.5e-25 88.7 11.3 5.2e-25 88.1 11.3 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO26988.1 - 1.9e-11 43.8 9.5 8.8e-11 41.6 9.5 2.2 1 1 0 1 1 1 1 Ion channel cNMP_binding PF00027.29 KOO26988.1 - 2.1e-11 43.7 0.0 5e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain TIR_2 PF13676.6 KOO26990.1 - 1.5e-05 25.6 0.0 0.00013 22.5 0.0 2.6 2 0 0 2 2 2 1 TIR domain DUF1840 PF08895.11 KOO26990.1 - 0.72 10.2 10.4 0.071 13.5 2.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) CASP_C PF08172.12 KOO26991.1 - 0.0054 16.1 7.5 0.72 9.1 0.6 3.5 3 0 0 3 3 3 2 CASP C terminal DUF812 PF05667.11 KOO26991.1 - 0.021 13.7 11.7 0.17 10.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DUF948 PF06103.11 KOO26991.1 - 0.26 11.6 5.4 46 4.4 0.7 3.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Fungal_TACC PF12709.7 KOO26991.1 - 2 8.9 5.0 15 6.1 0.4 3.2 2 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Peptidase_S49 PF01343.18 KOO26992.1 - 8.4e-42 142.7 0.0 1.5e-41 141.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S49 Peptidase_S49_N PF08496.10 KOO26992.1 - 1.2e-15 57.9 0.0 2.2e-13 50.5 0.0 2.8 2 0 0 2 2 2 2 Peptidase family S49 N-terminal SDH_sah PF01972.16 KOO26992.1 - 0.0094 15.0 0.1 0.0094 15.0 0.1 1.7 2 0 0 2 2 2 1 Serine dehydrogenase proteinase LSM PF01423.22 KOO26993.1 - 3.7e-19 68.2 0.4 5.6e-19 67.6 0.4 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 KOO26993.1 - 0.0064 16.1 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Hfq protein ADK PF00406.22 KOO26994.1 - 5.2e-58 195.4 0.0 7.4e-58 194.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO26994.1 - 1.2e-23 84.1 0.2 3.1e-23 82.7 0.0 1.8 3 0 0 3 3 3 1 AAA domain ADK_lid PF05191.14 KOO26994.1 - 2e-15 56.5 0.0 4e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 KOO26994.1 - 0.00097 19.5 1.6 1.6 8.9 0.0 2.9 2 1 1 3 3 3 2 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 KOO26994.1 - 0.0029 18.2 0.0 0.0086 16.6 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO26994.1 - 0.015 15.5 0.0 0.029 14.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 KOO26994.1 - 0.075 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase RuvB_N PF05496.12 KOO26994.1 - 0.1 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 KOO26994.1 - 0.14 11.5 0.1 0.19 11.1 0.1 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KOO26994.1 - 0.17 11.6 0.0 0.77 9.5 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein TPR_1 PF00515.28 KOO26995.1 - 3.4e-18 64.6 4.3 2.3e-07 30.3 0.2 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO26995.1 - 1.6e-10 40.3 7.3 0.00054 19.9 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO26995.1 - 1.4e-07 32.0 10.8 0.00011 22.7 2.4 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO26995.1 - 6e-07 29.4 0.1 0.03 14.7 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO26995.1 - 1.5e-06 28.4 2.7 9.3e-05 22.6 0.7 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO26995.1 - 1.7e-06 27.8 3.5 0.014 15.6 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO26995.1 - 7.5e-05 22.3 7.1 0.042 13.5 3.2 3.3 1 1 2 3 3 3 3 TPR repeat TPR_7 PF13176.6 KOO26995.1 - 0.0049 16.8 2.7 2.7 8.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO26995.1 - 0.011 15.9 5.6 0.069 13.3 0.6 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26995.1 - 0.013 16.0 2.1 0.022 15.3 0.8 2.0 1 1 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 KOO26995.1 - 0.019 15.0 0.4 0.033 14.3 0.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) MIT PF04212.18 KOO26995.1 - 0.099 12.7 2.9 1.6 8.8 0.0 2.6 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain LYTB PF02401.18 KOO26995.1 - 0.14 11.4 0.2 0.19 11.0 0.2 1.2 1 0 0 1 1 1 0 LytB protein Wzz PF02706.15 KOO26995.1 - 0.22 11.8 0.7 0.46 10.8 0.1 1.7 2 0 0 2 2 2 0 Chain length determinant protein Glyco_tranf_2_4 PF13704.6 KOO26996.1 - 4.1e-07 30.4 0.2 1e-06 29.1 0.2 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 p450 PF00067.22 KOO26997.1 - 8.5e-33 113.8 0.0 9.8e-33 113.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TPR_2 PF07719.17 KOO26998.1 - 1.1e-31 106.3 11.8 2.4e-06 27.2 0.0 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 KOO26998.1 - 7.5e-26 88.9 6.2 1.1e-06 28.1 0.0 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOO26998.1 - 1.6e-25 88.5 3.3 3.9e-06 26.4 0.0 7.4 3 2 4 7 7 7 5 TPR repeat TPR_8 PF13181.6 KOO26998.1 - 2.6e-19 67.7 1.8 9.9e-05 22.3 0.0 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO26998.1 - 3e-16 59.5 15.3 0.00037 20.7 0.9 6.5 3 1 3 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO26998.1 - 5.7e-15 55.7 23.7 3e-08 34.2 1.6 5.8 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO26998.1 - 5.7e-15 55.6 16.2 5.3e-05 23.6 0.7 5.8 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO26998.1 - 1.2e-12 47.5 24.7 0.0002 21.9 0.8 7.9 3 3 5 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO26998.1 - 2.3e-12 46.4 0.8 0.0087 16.4 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOO26998.1 - 7e-11 42.0 6.4 0.0016 19.0 0.1 6.5 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO26998.1 - 5.2e-10 38.9 11.4 0.0034 17.2 0.1 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO26998.1 - 1e-09 37.7 10.9 0.045 13.8 0.1 6.6 8 0 0 8 8 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO26998.1 - 4.5e-09 36.4 4.1 0.00034 20.8 0.6 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 KOO26998.1 - 4e-08 33.3 17.8 0.0015 18.7 0.0 5.8 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 KOO26998.1 - 8.4e-06 25.2 6.9 0.65 9.1 0.0 4.7 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_4 PF07721.14 KOO26998.1 - 3.7e-05 23.9 16.7 0.39 11.5 0.0 6.7 6 2 1 7 7 5 2 Tetratricopeptide repeat NARP1 PF12569.8 KOO26998.1 - 0.00035 19.6 4.5 0.16 10.9 0.1 3.3 3 1 1 4 4 4 2 NMDA receptor-regulated protein 1 MAS20 PF02064.15 KOO26998.1 - 0.0028 17.7 0.8 6.5 6.9 0.2 4.0 3 1 1 4 4 4 1 MAS20 protein import receptor Fis1_TPR_C PF14853.6 KOO26998.1 - 0.027 14.5 0.2 5.6 7.1 0.0 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 KOO26998.1 - 0.035 14.2 12.0 5.3 7.2 0.1 5.1 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 KOO26998.1 - 0.059 12.8 9.9 14 5.3 0.1 5.6 6 0 0 6 6 6 0 SHNi-TPR DUF4810 PF16068.5 KOO26998.1 - 0.16 12.6 0.7 31 5.2 0.1 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4810) Coatomer_E PF04733.14 KOO26998.1 - 0.91 8.9 4.8 9.4 5.5 0.1 2.9 2 1 1 3 3 3 0 Coatomer epsilon subunit DUF445 PF04286.12 KOO26999.1 - 6.1e-09 36.2 3.3 0.00012 22.1 0.0 3.4 2 1 1 3 3 3 2 Protein of unknown function (DUF445) AMP-binding PF00501.28 KOO26999.1 - 0.017 13.7 0.0 0.027 13.1 0.0 1.2 1 0 0 1 1 1 0 AMP-binding enzyme RskA PF10099.9 KOO26999.1 - 0.026 14.8 0.6 0.06 13.6 0.6 1.6 1 0 0 1 1 1 0 Anti-sigma-K factor rskA HSP33 PF01430.19 KOO27000.1 - 8.1e-49 166.4 0.0 9.2e-49 166.3 0.0 1.0 1 0 0 1 1 1 1 Hsp33 protein U-box PF04564.15 KOO27001.1 - 5.1e-10 39.4 0.0 1.1e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO27001.1 - 8.4e-09 35.8 9.2 2e-05 25.1 2.5 3.4 3 0 0 3 3 3 2 Sel1 repeat zf-Nse PF11789.8 KOO27001.1 - 0.00029 20.6 0.0 0.00064 19.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO27001.1 - 0.01 15.9 0.0 0.026 14.6 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein CZB PF13682.6 KOO27001.1 - 0.12 12.8 1.4 0.27 11.7 0.2 2.2 2 0 0 2 2 2 0 Chemoreceptor zinc-binding domain U-box PF04564.15 KOO27002.1 - 0.087 13.0 0.2 0.12 12.6 0.2 1.3 1 0 0 1 1 1 0 U-box domain Sel1 PF08238.12 KOO27003.1 - 4.4e-13 49.4 12.3 1e-07 32.4 1.6 3.7 3 0 0 3 3 3 2 Sel1 repeat U-box PF04564.15 KOO27003.1 - 2.7e-12 46.7 0.0 4.6e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 KOO27003.1 - 0.0012 19.0 0.0 0.0024 18.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO27003.1 - 0.004 17.0 0.0 0.0071 16.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Sel1 PF08238.12 KOO27004.1 - 2e-10 41.0 7.0 8.9e-05 23.0 0.6 3.6 3 0 0 3 3 3 2 Sel1 repeat U-box PF04564.15 KOO27004.1 - 2.9e-10 40.2 0.0 5.2e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO27004.1 - 0.00057 19.6 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO27004.1 - 0.0014 18.7 0.0 0.0037 17.4 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein DnaJ PF00226.31 KOO27005.1 - 3.8e-12 46.1 0.5 1.2e-11 44.5 0.1 2.1 2 0 0 2 2 2 1 DnaJ domain TPR_11 PF13414.6 KOO27005.1 - 0.007 16.0 4.0 12 5.7 0.0 3.8 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.6 KOO27005.1 - 0.037 14.5 6.8 2.3 8.8 0.9 3.2 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27005.1 - 0.067 13.3 4.9 0.97 9.7 0.4 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.12 KOO27007.1 - 7.1e-12 45.6 8.6 1.7e-05 25.4 0.3 4.1 3 1 1 4 4 4 3 Sel1 repeat U-box PF04564.15 KOO27007.1 - 2.3e-10 40.5 0.0 5.6e-10 39.3 0.0 1.6 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 KOO27007.1 - 0.00067 19.4 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO27007.1 - 0.015 15.4 0.0 0.043 13.9 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TPR_2 PF07719.17 KOO27008.1 - 3.6e-29 98.5 20.4 9.7e-05 22.2 0.0 7.9 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 KOO27008.1 - 2.8e-28 97.3 16.7 6.8e-09 35.3 0.4 7.1 6 1 1 7 7 7 6 TPR repeat TPR_1 PF00515.28 KOO27008.1 - 7.7e-27 92.0 16.5 7.4e-05 22.4 0.0 8.5 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27008.1 - 1e-19 69.0 2.7 0.0028 17.7 0.0 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO27008.1 - 1.8e-19 68.6 20.6 0.0003 21.0 0.3 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27008.1 - 1.1e-17 64.3 32.8 4.6e-09 36.8 3.5 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO27008.1 - 7.3e-14 51.8 19.7 9.4e-07 29.0 0.4 6.5 2 1 4 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO27008.1 - 6.7e-11 42.1 20.9 0.3 12.0 0.4 7.4 4 1 3 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO27008.1 - 2e-10 41.0 20.4 9.4e-06 26.0 0.9 4.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO27008.1 - 1.9e-09 37.5 11.9 0.0012 18.9 0.1 5.3 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO27008.1 - 3.4e-09 36.1 5.4 0.027 14.5 0.0 6.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOO27008.1 - 7.6e-07 29.4 6.0 0.077 13.7 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.6 KOO27008.1 - 0.011 16.1 11.3 10 6.6 0.6 5.2 3 2 3 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO27008.1 - 0.031 14.1 32.1 0.71 9.8 1.2 7.4 9 0 0 9 9 9 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO27008.1 - 0.04 14.2 7.5 0.48 10.7 0.2 3.8 2 1 3 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.12 KOO27008.1 - 0.045 13.5 2.8 5.7 6.6 0.7 3.0 1 1 2 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 FAT PF02259.23 KOO27008.1 - 0.086 12.0 0.7 3.3 6.8 0.0 2.3 2 0 0 2 2 2 0 FAT domain BTAD PF03704.17 KOO27008.1 - 0.092 13.2 8.9 0.18 12.3 0.2 3.3 2 1 1 3 3 3 0 Bacterial transcriptional activator domain Glyoxalase PF00903.25 KOO27008.1 - 0.15 12.3 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HrpB1_HrpK PF09613.10 KOO27008.1 - 0.3 10.7 2.3 0.32 10.6 0.1 2.1 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) Bestrophin PF01062.21 KOO27009.1 - 5.9e-28 98.1 1.7 7.6e-28 97.7 1.7 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel MotB_plug PF13677.6 KOO27009.1 - 0.58 9.8 3.2 0.87 9.2 0.0 2.5 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB U-box PF04564.15 KOO27010.1 - 1.2e-10 41.4 0.0 2.6e-10 40.3 0.0 1.5 2 0 0 2 2 2 1 U-box domain Sel1 PF08238.12 KOO27010.1 - 1.6e-09 38.2 8.5 0.00012 22.7 0.6 3.6 3 0 0 3 3 3 2 Sel1 repeat zf-Nse PF11789.8 KOO27010.1 - 0.00027 20.7 0.0 0.00048 19.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO27010.1 - 0.0055 16.8 0.0 0.017 15.2 0.0 1.8 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein DUF469 PF04320.14 KOO27010.1 - 0.035 15.0 0.2 1.8 9.5 0.0 2.6 2 1 0 2 2 2 0 Protein with unknown function (DUF469) MKLP1_Arf_bdg PF16540.5 KOO27010.1 - 0.072 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Arf6-interacting domain of mitotic kinesin-like protein 1 CZB PF13682.6 KOO27010.1 - 0.18 12.3 2.6 0.36 11.3 0.9 2.3 3 0 0 3 3 3 0 Chemoreceptor zinc-binding domain LRR_4 PF12799.7 KOO27011.1 - 1.5e-09 38.0 34.4 7.4e-05 23.0 0.1 10.1 9 1 0 9 9 9 2 Leucine Rich repeats (2 copies) EF-hand_1 PF00036.32 KOO27011.1 - 3.3e-07 29.4 2.3 1e-06 27.9 2.3 1.9 1 0 0 1 1 1 1 EF hand LRR_8 PF13855.6 KOO27011.1 - 5.1e-06 26.1 28.6 0.00088 19.0 0.1 8.6 7 2 1 8 8 8 3 Leucine rich repeat EF-hand_5 PF13202.6 KOO27011.1 - 8e-06 25.1 2.1 3.4e-05 23.2 2.1 2.2 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO27011.1 - 0.00032 20.4 0.5 0.0014 18.4 0.5 2.2 1 0 0 1 1 1 1 EF-hand domain LRR_6 PF13516.6 KOO27011.1 - 0.00084 19.2 34.3 0.13 12.3 0.7 13.5 15 1 0 15 15 15 1 Leucine Rich repeat EF-hand_8 PF13833.6 KOO27011.1 - 0.0013 18.6 1.8 0.0059 16.4 1.8 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 KOO27011.1 - 0.0016 18.9 1.2 0.0048 17.3 1.2 1.9 1 0 0 1 1 1 1 EF-hand domain pair AAA_19 PF13245.6 KOO27011.1 - 0.0069 16.7 0.1 0.022 15.1 0.1 1.9 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 KOO27011.1 - 0.031 13.8 4.2 0.17 11.3 0.0 2.8 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain LRR_9 PF14580.6 KOO27011.1 - 0.085 12.4 0.7 0.31 10.5 0.7 2.0 1 0 0 1 1 1 0 Leucine-rich repeat ABATE PF07336.11 KOO27011.1 - 0.11 13.2 0.2 5.1 7.8 0.0 3.2 2 0 0 2 2 2 0 Putative stress-induced transcription regulator Peptidase_S28 PF05577.12 KOO27013.1 - 1.3e-65 221.9 0.2 1e-48 166.2 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 KOO27013.1 - 3.1e-05 22.8 0.0 5.4e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 PS-10 peptidase S37 Hydrolase_4 PF12146.8 KOO27013.1 - 0.0049 16.2 0.0 0.01 15.1 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO27013.1 - 0.011 15.4 0.1 0.025 14.2 0.1 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Galactosyl_T PF01762.21 KOO27014.1 - 3.8e-06 26.9 0.0 6.2e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 KOO27014.1 - 0.075 12.5 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Fringe-like TAXi_N PF14543.6 KOO27015.1 - 4.1e-27 95.5 0.6 8.2e-27 94.6 0.6 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp PF00026.23 KOO27015.1 - 1.5e-16 60.7 0.0 6.8e-11 42.1 0.0 2.9 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.6 KOO27015.1 - 1.4e-07 31.4 0.0 2.6e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Metallophos PF00149.28 KOO27016.1 - 0.027 15.0 0.5 0.1 13.1 0.5 2.0 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase FoP_duplication PF13865.6 KOO27016.1 - 0.066 13.8 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 fn3 PF00041.21 KOO27017.1 - 0.18 12.2 0.0 0.36 11.2 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain His_Phos_1 PF00300.22 KOO27019.1 - 3.1e-31 108.6 0.0 1.5e-24 86.8 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) PH PF00169.29 KOO27020.1 - 2.3e-10 40.9 0.1 4e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KOO27020.1 - 0.00076 19.7 0.6 0.0019 18.4 0.6 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain WW PF00397.26 KOO27020.1 - 0.018 15.1 7.8 0.022 14.8 4.1 2.9 2 1 0 2 2 2 0 WW domain GyrB_insert PF18053.1 KOO27021.1 - 0.09 12.7 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain PAS PF00989.25 KOO27022.1 - 2.7e-48 162.6 0.1 2.6e-16 59.6 0.0 3.8 3 0 0 3 3 3 3 PAS fold PAS_4 PF08448.10 KOO27022.1 - 5.4e-31 107.1 0.2 2.2e-09 37.5 0.0 4.1 3 0 0 3 3 3 3 PAS fold PAS_9 PF13426.7 KOO27022.1 - 1.1e-29 102.8 0.0 2e-12 47.3 0.1 3.7 3 0 0 3 3 3 3 PAS domain HATPase_c PF02518.26 KOO27022.1 - 5.6e-27 94.5 0.0 2e-26 92.7 0.0 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOO27022.1 - 6.2e-23 81.1 0.0 2.4e-22 79.2 0.0 2.1 1 0 0 1 1 1 1 Response regulator receiver domain PAS_3 PF08447.12 KOO27022.1 - 1.2e-16 60.8 0.0 1.5e-07 31.6 0.0 3.6 3 0 0 3 3 3 3 PAS fold HisKA PF00512.25 KOO27022.1 - 9.6e-15 54.4 0.0 9.6e-15 54.4 0.0 3.1 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 KOO27022.1 - 3.5e-13 49.2 0.0 0.0002 21.3 0.0 4.4 4 0 0 4 4 4 3 PAS domain Hpt PF01627.23 KOO27022.1 - 4.5e-08 33.3 9.5 2.8e-07 30.7 0.9 3.7 3 0 0 3 3 3 1 Hpt domain PAS_10 PF13596.6 KOO27022.1 - 6e-08 33.2 0.0 0.00012 22.6 0.0 2.9 2 0 0 2 2 2 2 PAS domain MLTR_LBD PF17765.1 KOO27022.1 - 0.001 19.2 2.8 0.013 15.6 0.3 2.9 2 0 0 2 2 2 1 MmyB-like transcription regulator ligand binding domain HATPase_c_3 PF13589.6 KOO27022.1 - 0.042 13.7 0.0 0.21 11.4 0.0 2.1 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K_oxygenase PF13434.6 KOO27024.1 - 1.9e-06 27.2 0.0 8.2e-06 25.2 0.0 1.8 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 KOO27024.1 - 0.0023 17.3 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 KOO27024.1 - 0.0028 18.1 0.0 0.0056 17.1 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Oxidored_nitro PF00148.19 KOO27024.1 - 0.044 12.5 0.0 0.09 11.5 0.0 1.5 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Pyr_redox PF00070.27 KOO27024.1 - 0.11 13.1 0.0 0.24 12.0 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase EF-hand_6 PF13405.6 KOO27025.1 - 7.5e-29 97.2 12.2 3.3e-06 26.6 0.1 6.8 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.32 KOO27025.1 - 1.6e-26 89.8 18.8 6.6e-05 22.2 0.3 6.8 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO27025.1 - 8e-25 87.1 11.2 4.7e-08 33.4 0.5 5.0 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO27025.1 - 7.9e-17 59.9 18.1 0.0012 18.3 0.4 6.4 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO27025.1 - 3.2e-13 49.3 12.6 0.0012 18.7 0.8 5.8 4 1 1 5 5 5 5 EF-hand domain pair DUF693 PF05113.13 KOO27025.1 - 0.14 11.4 0.0 11 5.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF693) LCE6A PF15858.5 KOO27025.1 - 0.88 10.4 3.3 3 8.6 3.3 1.9 1 0 0 1 1 1 0 Late cornified envelope protein 6A family EF-hand_4 PF12763.7 KOO27025.1 - 1.4 9.0 3.9 5.7 7.0 0.0 3.2 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Tau95 PF09734.9 KOO27025.1 - 8.4 7.2 7.9 19 6.0 2.1 5.2 2 0 0 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain LRR_6 PF13516.6 KOO27026.1 - 3.7e-05 23.5 1.6 0.13 12.4 0.0 3.8 3 0 0 3 3 3 3 Leucine Rich repeat Ribosomal_S16 PF00886.19 KOO27027.1 - 1.4e-20 73.1 0.0 1.9e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 zf-RING_2 PF13639.6 KOO27028.1 - 0.00048 20.4 7.2 0.0016 18.7 7.2 2.0 1 1 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 KOO27028.1 - 0.12 12.6 2.8 0.31 11.2 2.8 1.8 1 0 0 1 1 1 0 FANCL C-terminal domain TPR_12 PF13424.6 KOO27029.1 - 4.3e-35 119.8 31.9 2.6e-14 53.3 2.1 6.6 3 3 5 8 8 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 KOO27029.1 - 6.2e-35 118.1 28.3 1.2e-08 34.5 0.0 9.6 9 2 0 9 9 9 7 Tetratricopeptide repeat EF-hand_1 PF00036.32 KOO27029.1 - 7.5e-11 40.8 0.1 0.00032 20.0 0.1 2.9 2 1 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO27029.1 - 1.9e-10 41.1 0.0 5.3e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO27029.1 - 1.3e-08 34.1 0.0 0.00019 21.1 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain TPR_1 PF00515.28 KOO27029.1 - 7.3e-08 31.9 14.7 0.26 11.2 0.1 6.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO27029.1 - 1.1e-07 31.4 14.7 0.23 11.6 0.0 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat EF-hand_8 PF13833.6 KOO27029.1 - 7.1e-07 29.0 0.2 3.7e-05 23.5 0.0 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO27029.1 - 7.8e-07 28.3 0.1 0.00044 19.6 0.1 2.9 2 0 0 2 2 2 2 EF hand TPR_2 PF07719.17 KOO27029.1 - 9.4e-05 22.2 26.1 0.23 11.6 0.1 7.8 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27029.1 - 0.052 13.8 21.5 1.2 9.5 0.1 7.2 7 1 1 8 8 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27029.1 - 0.055 14.1 0.8 0.055 14.1 0.8 7.2 5 2 3 8 8 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO27029.1 - 0.1 13.0 9.4 12 6.6 0.1 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat SPARC_Ca_bdg PF10591.9 KOO27029.1 - 0.11 12.8 0.3 0.4 11.0 0.0 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO27029.1 - 0.18 11.8 0.0 0.46 10.4 0.0 1.6 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Adap_comp_sub PF00928.21 KOO27030.1 - 2.5e-61 207.4 0.0 3e-61 207.1 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family VKG_Carbox PF05090.14 KOO27031.1 - 1.2e-22 80.4 0.7 6.4e-21 74.7 0.9 2.3 1 1 1 2 2 2 2 Vitamin K-dependent gamma-carboxylase C2 PF00168.30 KOO27033.1 - 4.7e-15 55.7 0.1 7.5e-15 55.1 0.1 1.3 1 0 0 1 1 1 1 C2 domain cNMP_binding PF00027.29 KOO27033.1 - 2.5e-11 43.5 0.0 5.3e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ank_3 PF13606.6 KOO27033.1 - 0.0033 17.8 6.3 11 7.0 0.1 5.4 5 0 0 5 5 5 1 Ankyrin repeat Ank_5 PF13857.6 KOO27033.1 - 0.016 15.6 0.2 4.2 7.8 0.1 3.8 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Bestrophin PF01062.21 KOO27034.1 - 2.4e-18 66.6 0.3 1.6e-17 63.8 0.1 1.8 1 1 1 2 2 2 1 Bestrophin, RFP-TM, chloride channel DGF-1_4 PF11024.8 KOO27034.1 - 0.051 14.4 0.1 0.1 13.4 0.1 1.5 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 INTS2 PF14750.6 KOO27034.1 - 0.18 9.3 0.0 0.25 8.8 0.0 1.1 1 0 0 1 1 1 0 Integrator complex subunit 2 Peptidase_C2 PF00648.21 KOO27035.1 - 8e-42 143.3 0.0 4.1e-41 140.9 0.0 1.9 1 1 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KOO27035.1 - 2.8e-06 27.6 0.0 0.012 15.9 0.0 2.8 2 1 0 2 2 2 2 Calpain large subunit, domain III DUF2475 PF10629.9 KOO27036.1 - 6.2e-10 39.1 15.0 0.027 14.7 0.7 4.5 4 0 0 4 4 4 4 Protein of unknown function (DUF2475) zf-CSL PF05207.13 KOO27037.1 - 9.7e-12 44.4 0.3 1.9e-11 43.5 0.3 1.5 1 0 0 1 1 1 1 CSL zinc finger zinc_ribbon_4 PF13717.6 KOO27037.1 - 0.0079 16.1 0.5 0.012 15.5 0.5 1.3 1 0 0 1 1 1 1 zinc-ribbon domain RRS1 PF04939.12 KOO27037.1 - 0.2 11.5 0.5 0.25 11.2 0.5 1.1 1 0 0 1 1 1 0 Ribosome biogenesis regulatory protein (RRS1) Metallophos_2 PF12850.7 KOO27038.1 - 0.0011 19.2 0.2 0.012 15.9 0.2 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 KOO27038.1 - 0.025 15.1 0.0 0.032 14.7 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase EF-hand_5 PF13202.6 KOO27039.1 - 6.8e-19 66.4 6.8 3.5e-06 26.3 0.1 3.8 2 1 2 4 4 4 3 EF hand EF-hand_1 PF00036.32 KOO27039.1 - 1.6e-16 58.5 1.7 6.5e-05 22.2 0.0 3.4 2 1 1 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO27039.1 - 1.6e-14 52.5 1.2 7.9e-05 22.3 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO27039.1 - 8.1e-10 39.0 0.9 0.011 16.1 0.0 3.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO27039.1 - 3.2e-07 30.1 2.5 0.025 14.4 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain pair 5_nucleotid_C PF02872.18 KOO27039.1 - 0.00026 21.2 0.0 0.00043 20.5 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Dockerin_1 PF00404.18 KOO27039.1 - 0.0061 16.7 0.1 2.7 8.3 0.0 3.1 3 0 0 3 3 3 1 Dockerin type I domain Sterol_MT_C PF08498.10 KOO27041.1 - 1.1e-22 80.1 0.7 2.6e-22 78.9 0.7 1.6 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 KOO27041.1 - 1.3e-18 67.4 0.0 2.5e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO27041.1 - 2e-16 60.4 0.0 3.6e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO27041.1 - 7.7e-14 51.7 0.0 1.1e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO27041.1 - 2.6e-12 46.6 0.0 3.7e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 KOO27041.1 - 1.7e-07 31.2 0.0 2.9e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO27041.1 - 3.6e-07 29.7 0.0 5.6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 KOO27041.1 - 4.2e-06 27.4 0.0 1.2e-05 26.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain CotE PF10628.9 KOO27041.1 - 0.038 13.6 0.3 0.06 13.0 0.3 1.2 1 0 0 1 1 1 0 Outer spore coat protein E (CotE) Tubulin PF00091.25 KOO27042.1 - 5.1e-26 92.1 0.0 5.6e-26 92.0 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Arm PF00514.23 KOO27043.1 - 6.1e-14 51.5 32.7 0.0012 18.8 0.9 9.5 9 0 0 9 9 9 5 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.8 KOO27043.1 - 0.096 12.8 0.0 0.7 10.0 0.0 2.4 2 1 1 3 3 3 0 V-ATPase subunit H SEN1_N PF12726.7 KOO27043.1 - 0.19 9.9 0.4 7.2 4.7 0.1 2.2 2 0 0 2 2 2 0 SEN1 N terminal CCDC66 PF15236.6 KOO27044.1 - 2.3 8.1 28.1 0.016 15.1 19.7 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 66 LRR_8 PF13855.6 KOO27045.1 - 0.034 13.9 0.2 11 5.8 0.1 2.6 2 0 0 2 2 2 0 Leucine rich repeat LRR_4 PF12799.7 KOO27045.1 - 0.063 13.7 0.5 0.58 10.7 0.5 2.5 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO27045.1 - 0.091 13.4 0.1 50 5.0 0.0 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_6 PF13516.6 KOO27045.1 - 0.15 12.2 9.1 5.5 7.3 0.1 4.2 5 0 0 5 5 5 0 Leucine Rich repeat DUF3301 PF11743.8 KOO27046.1 - 0.22 11.2 2.3 0.28 10.9 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3301) PI3K_P85_iSH2 PF16454.5 KOO27046.1 - 0.27 10.8 7.3 2 8.0 0.6 2.8 2 2 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TMF_DNA_bd PF12329.8 KOO27046.1 - 1.5 8.8 12.6 0.21 11.6 3.8 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding EF-hand_7 PF13499.6 KOO27047.1 - 0.021 15.3 0.0 0.063 13.7 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 KOO27047.1 - 0.04 13.5 0.3 0.41 10.3 0.1 2.5 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 KOO27047.1 - 0.071 13.1 0.2 0.23 11.5 0.2 1.8 1 0 0 1 1 1 0 EF-hand domain TPR_19 PF14559.6 KOO27047.1 - 0.62 10.6 9.8 7.4 7.2 0.5 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat SURF6 PF04935.12 KOO27047.1 - 1.2 8.9 9.8 2 8.1 9.8 1.3 1 0 0 1 1 1 0 Surfeit locus protein 6 Sec23_trunk PF04811.15 KOO27049.1 - 6.2e-61 206.0 0.0 9.5e-61 205.4 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 KOO27049.1 - 4.6e-30 104.2 0.1 8.6e-30 103.3 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 KOO27049.1 - 1.5e-21 76.2 0.7 4.9e-21 74.5 0.1 2.3 3 0 0 3 3 3 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 KOO27049.1 - 3.4e-14 52.6 8.5 8.2e-14 51.4 8.5 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KOO27049.1 - 2.5e-12 46.5 0.0 4.8e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 KOO27049.1 - 0.039 14.6 0.0 29 5.4 0.0 3.1 3 0 0 3 3 3 0 von Willebrand factor type A domain Vps36-NZF-N PF16988.5 KOO27049.1 - 0.053 12.9 0.2 0.12 11.8 0.2 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-MYST PF17772.1 KOO27049.1 - 2.1 8.0 7.4 1 9.0 0.5 3.2 4 0 0 4 4 4 0 MYST family zinc finger domain Sec23_BS PF08033.12 KOO27050.1 - 1.6e-30 105.7 0.1 3.1e-30 104.8 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 KOO27050.1 - 9.7e-22 76.7 0.9 1.8e-21 75.9 0.1 1.8 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 KOO27050.1 - 9.5e-13 47.9 0.0 1.8e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Gelsolin repeat Sec23_trunk PF04811.15 KOO27050.1 - 0.013 15.1 0.1 0.023 14.2 0.1 1.5 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain EF-hand_1 PF00036.32 KOO27052.1 - 1.6e-34 114.8 2.3 0.00022 20.5 0.2 6.4 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO27052.1 - 2.5e-33 111.1 2.4 6.1e-05 22.6 0.1 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.6 KOO27052.1 - 1.1e-31 106.9 4.5 0.00066 19.1 0.1 6.4 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO27052.1 - 7.6e-27 93.6 0.1 1.4e-07 31.8 0.0 4.8 2 2 2 5 5 5 5 EF-hand domain pair EF-hand_8 PF13833.6 KOO27052.1 - 1.2e-21 76.3 1.6 0.00013 21.7 0.1 6.2 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_14 PF17959.1 KOO27052.1 - 0.049 14.0 0.0 0.93 9.9 0.0 3.0 3 1 1 4 4 4 0 EF-hand domain TK PF00265.18 KOO27053.1 - 1.3e-34 119.6 0.0 1.5e-34 119.4 0.0 1.0 1 0 0 1 1 1 1 Thymidine kinase AAA_22 PF13401.6 KOO27053.1 - 0.00017 21.9 0.0 0.00025 21.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO27053.1 - 0.00059 19.6 0.0 0.0011 18.7 0.0 1.4 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 KOO27053.1 - 0.0028 17.7 0.1 0.0078 16.2 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO27053.1 - 0.077 13.3 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO27053.1 - 0.1 11.8 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DJ-1_PfpI PF01965.24 KOO27054.1 - 4.3e-29 101.4 0.0 5.5e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 KOO27054.1 - 0.021 14.4 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 KOO27054.1 - 0.026 14.3 0.0 0.064 13.0 0.0 1.7 1 1 0 1 1 1 0 Glutamine amidotransferase class-I DUF179 PF02622.15 KOO27055.1 - 5.6e-09 36.2 0.0 1.3e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 Ank_2 PF12796.7 KOO27055.1 - 2.3e-05 24.9 0.0 5.5e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO27055.1 - 0.0001 22.8 0.0 0.00026 21.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO27055.1 - 0.00021 21.6 0.7 0.014 15.8 0.2 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 KOO27055.1 - 0.00029 21.1 0.2 0.066 13.8 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 KOO27055.1 - 0.00068 19.9 0.0 0.13 12.6 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) EF-hand_1 PF00036.32 KOO27056.1 - 0.058 13.0 0.1 0.36 10.5 0.0 2.2 2 0 0 2 2 2 0 EF hand IZUMO PF15005.6 KOO27056.1 - 0.19 12.3 2.5 0.47 11.0 0.0 3.0 3 0 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated Sfi1 PF08457.10 KOO27056.1 - 0.56 8.7 97.8 0.013 14.1 9.8 6.3 2 2 4 6 6 6 0 Sfi1 spindle body protein Phage_GP20 PF06810.11 KOO27056.1 - 3.9 7.3 14.6 0.81 9.5 0.5 3.4 3 1 0 3 3 3 0 Phage minor structural protein GP20 CK2S PF15011.6 KOO27056.1 - 8 6.3 21.2 0.57 10.1 0.2 3.2 3 0 0 3 3 3 0 Casein Kinase 2 substrate Kinesin PF00225.23 KOO27057.1 - 3.1e-100 335.4 0.2 2.4e-99 332.5 0.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOO27057.1 - 4.7e-22 78.5 0.0 4.9e-20 72.0 0.0 2.8 2 0 0 2 2 2 2 Microtubule binding Arm PF00514.23 KOO27060.1 - 6.7e-05 22.8 0.8 0.036 14.1 0.2 2.9 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat IFRD PF05004.13 KOO27060.1 - 0.9 8.6 8.5 6.5 5.8 6.6 2.7 1 1 1 2 2 2 0 Interferon-related developmental regulator (IFRD) HECT PF00632.25 KOO27061.1 - 1e-80 271.5 0.0 2.1e-79 267.2 0.0 2.4 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) RCC1 PF00415.18 KOO27061.1 - 7.2e-25 87.4 0.3 1.8e-08 34.8 0.4 3.5 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO27061.1 - 0.00041 20.1 16.3 0.11 12.3 0.7 3.6 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat HTH_ParB PF17762.1 KOO27061.1 - 0.062 13.1 0.1 0.062 13.1 0.1 2.2 2 0 0 2 2 2 0 HTH domain found in ParB protein CAP_N PF01213.19 KOO27061.1 - 0.74 9.2 4.4 1.3 8.4 4.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PDEase_I PF00233.19 KOO27062.1 - 0.08 12.7 0.1 0.098 12.4 0.1 1.1 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase Peptidase_S9 PF00326.21 KOO27063.1 - 3.8e-06 26.5 0.0 8.1e-06 25.5 0.0 1.5 2 0 0 2 2 2 1 Prolyl oligopeptidase family NeA_P2 PF12312.8 KOO27063.1 - 0.0021 17.6 0.4 0.0084 15.6 0.1 1.9 2 0 0 2 2 2 1 Nepovirus subgroup A polyprotein CAP_N PF01213.19 KOO27063.1 - 0.35 10.3 9.8 0.078 12.5 1.3 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal KAP PF05804.12 KOO27064.1 - 6.2e-159 530.4 0.9 7.3e-159 530.2 0.9 1.0 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) PUL PF08324.11 KOO27064.1 - 0.00014 21.3 5.4 0.01 15.1 0.8 3.6 2 1 1 3 3 3 1 PUL domain Beta-lactamase PF00144.24 KOO27064.1 - 0.0047 16.2 2.7 3.2 6.9 0.0 2.9 3 0 0 3 3 3 2 Beta-lactamase Arm_2 PF04826.13 KOO27064.1 - 0.0049 16.4 8.0 0.15 11.5 0.0 3.9 4 1 1 5 5 5 2 Armadillo-like FoP_duplication PF13865.6 KOO27064.1 - 0.077 13.5 4.9 0.22 12.1 4.9 1.7 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Arm PF00514.23 KOO27064.1 - 0.22 11.7 5.0 11 6.3 0.1 4.4 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat PrmA PF06325.13 KOO27066.1 - 1.6e-05 24.4 1.6 2.3e-05 23.9 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PRMT5 PF05185.16 KOO27066.1 - 3.1e-05 23.9 0.0 0.00012 22.0 0.0 1.8 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_18 PF12847.7 KOO27066.1 - 0.00014 21.8 0.1 0.00023 21.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO27066.1 - 0.00071 19.2 0.3 0.0012 18.5 0.3 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.6 KOO27066.1 - 0.0011 20.0 0.4 0.0024 18.9 0.3 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO27066.1 - 0.0023 18.6 0.2 0.0049 17.6 0.2 1.7 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 KOO27066.1 - 0.0032 17.2 0.0 0.0047 16.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 KOO27066.1 - 0.038 13.6 0.1 0.058 13.0 0.1 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CMAS PF02353.20 KOO27066.1 - 0.047 13.0 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase TrmK PF04816.12 KOO27066.1 - 0.12 11.9 0.1 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase Methyltransf_4 PF02390.17 KOO27066.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase CbiX PF01903.17 KOO27068.1 - 1.9e-08 34.6 0.0 0.0097 16.2 0.0 3.2 2 2 0 2 2 2 2 CbiX EF-hand_1 PF00036.32 KOO27070.1 - 8.1e-05 21.9 0.1 0.00032 20.0 0.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO27070.1 - 0.00015 21.4 0.2 0.00084 19.1 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 KOO27070.1 - 0.001 18.9 0.3 0.0023 17.7 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO27070.1 - 0.0011 18.4 0.1 0.0029 17.0 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO27070.1 - 0.0011 19.3 0.2 0.0044 17.4 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair DUF4407 PF14362.6 KOO27070.1 - 1 8.6 8.6 1.4 8.2 8.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.12 KOO27071.1 - 0.85 10.1 9.5 0.77 10.3 2.8 3.7 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein GIT_CC PF16559.5 KOO27071.1 - 2.6 8.0 8.7 0.7 9.8 2.2 3.5 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor SPATA1_C PF15743.5 KOO27072.1 - 1.1 9.4 18.3 0.66 10.0 1.0 3.4 1 1 1 3 3 3 0 Spermatogenesis-associated C-terminus BCDHK_Adom3 PF10436.9 KOO27073.1 - 1.2e-45 155.2 0.2 1.6e-45 154.8 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KOO27073.1 - 3.5e-13 50.1 0.0 7.7e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOO27073.1 - 0.0005 19.9 0.0 0.00077 19.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UBA_4 PF14555.6 KOO27075.1 - 0.00037 20.2 0.0 0.0045 16.8 0.1 2.6 2 0 0 2 2 2 1 UBA-like domain Flg_hook PF02120.16 KOO27075.1 - 0.038 13.9 0.2 7.4 6.5 0.1 3.3 3 0 0 3 3 3 0 Flagellar hook-length control protein FliK RA PF00788.23 KOO27075.1 - 0.062 13.9 0.1 20 5.9 0.0 2.8 1 1 1 2 2 2 0 Ras association (RalGDS/AF-6) domain DUF5319 PF17252.2 KOO27075.1 - 2.7 8.2 6.2 92 3.3 0.1 4.6 5 0 0 5 5 5 0 Family of unknown function (DUF5319) adh_short_C2 PF13561.6 KOO27076.1 - 4.2e-49 167.2 0.2 6.5e-47 160.1 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO27076.1 - 8.9e-11 41.6 0.3 1.6e-07 31.0 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase DUF647 PF04884.14 KOO27077.1 - 3.6e-50 170.8 5.6 4.2e-50 170.6 5.6 1.0 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis Ank_2 PF12796.7 KOO27079.1 - 1.6e-32 111.9 1.3 2.2e-13 50.6 0.1 3.1 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO27079.1 - 5.9e-28 96.9 10.2 9.6e-13 48.4 0.3 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO27079.1 - 4.1e-17 62.0 5.5 6.9e-06 26.2 0.1 4.7 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27079.1 - 6.2e-16 56.9 0.8 9.2e-05 22.6 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 KOO27079.1 - 1.3e-13 50.7 2.0 8.8e-05 22.8 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat PABP PF00658.18 KOO27081.1 - 1.4e-14 54.0 0.1 2.1e-14 53.5 0.1 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Kelch_4 PF13418.6 KOO27081.1 - 1.3e-13 50.8 7.6 3.6e-08 33.3 0.0 4.0 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KOO27081.1 - 1.2e-08 35.1 7.7 1.1e-05 25.6 0.2 4.1 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO27081.1 - 3.5e-08 33.4 0.8 0.009 16.3 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 KOO27081.1 - 6.6e-07 29.2 0.0 0.8 9.8 0.0 3.8 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KOO27081.1 - 8.4 6.1 8.6 15 5.3 0.1 3.8 4 0 0 4 4 4 0 Kelch motif Helicase_C PF00271.31 KOO27083.1 - 4.7e-17 62.3 0.4 1.8e-16 60.4 0.4 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Phage_integrase PF00589.22 KOO27083.1 - 0.071 12.9 0.8 0.22 11.3 0.8 1.7 1 1 0 1 1 1 0 Phage integrase family Ras PF00071.22 KOO27084.1 - 7.7e-63 210.9 0.5 9e-63 210.7 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO27084.1 - 2e-35 121.6 0.4 3.2e-35 121.0 0.4 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO27084.1 - 1.1e-16 60.8 0.3 1.3e-16 60.5 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KOO27084.1 - 5.9e-07 29.5 0.1 0.021 14.8 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOO27084.1 - 4e-06 26.5 0.6 7.9e-06 25.5 0.6 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KOO27084.1 - 3.5e-05 23.3 0.2 4.4e-05 23.0 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO27084.1 - 4.7e-05 23.4 0.1 0.0001 22.4 0.0 1.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 KOO27084.1 - 0.00018 21.0 0.0 0.00027 20.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KOO27084.1 - 0.0079 16.6 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO27084.1 - 0.0081 16.4 0.0 0.017 15.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 KOO27084.1 - 0.042 14.4 0.1 0.065 13.7 0.1 1.6 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 KOO27084.1 - 0.047 13.6 0.0 0.08 12.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain FeoB_N PF02421.18 KOO27084.1 - 0.066 12.7 0.0 0.32 10.5 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_33 PF13671.6 KOO27084.1 - 0.078 13.1 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO27084.1 - 0.081 12.7 0.1 0.48 10.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AMP-binding PF00501.28 KOO27085.1 - 2.1e-52 178.2 0.0 2.9e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOO27085.1 - 2.5e-05 25.2 0.0 6.1e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 KOO27085.1 - 0.034 13.0 0.0 0.11 11.3 0.0 1.7 2 0 0 2 2 2 0 GH3 auxin-responsive promoter EF-hand_6 PF13405.6 KOO27086.1 - 8.4e-09 34.7 0.5 0.0033 17.2 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO27086.1 - 1.9e-07 30.2 2.3 0.00065 19.1 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO27086.1 - 1.2e-06 28.9 0.0 0.0014 19.0 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO27086.1 - 9.2e-06 25.4 0.5 0.00036 20.3 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO27086.1 - 0.13 11.9 3.8 0.25 10.9 0.2 2.9 3 0 0 3 3 3 0 EF hand RNA_pol_Rpc4 PF05132.14 KOO27086.1 - 0.29 11.5 7.3 0.67 10.4 4.9 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 Asp-B-Hydro_N PF05279.11 KOO27086.1 - 3.2 7.8 16.2 0.45 10.6 11.8 1.6 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region RSRP PF17069.5 KOO27086.1 - 4.2 6.8 6.9 6.7 6.2 6.9 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 EKLF_TAD2 PF16833.5 KOO27087.1 - 6.9 6.8 5.6 0.71 9.9 0.5 2.1 2 0 0 2 2 2 0 Erythroid krueppel-like transcription factor, transactivation 2 SelR PF01641.18 KOO27089.1 - 5.9e-05 23.1 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 SelR domain zf-CW PF07496.15 KOO27090.1 - 1.7e-11 44.0 2.2 4e-11 42.7 2.2 1.7 1 0 0 1 1 1 1 CW-type Zinc Finger FAD_binding_3 PF01494.19 KOO27091.1 - 3.7e-18 65.9 1.2 4.7e-08 32.7 0.0 2.8 3 1 0 3 3 3 2 FAD binding domain FAD_binding_2 PF00890.24 KOO27091.1 - 4.2e-05 22.8 1.4 9.5e-05 21.6 1.4 1.6 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KOO27091.1 - 5.2e-05 23.4 1.6 0.00029 21.0 0.5 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KOO27091.1 - 0.0028 16.4 0.4 0.0052 15.5 0.4 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 KOO27091.1 - 0.0029 16.9 0.3 0.0059 15.9 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOO27091.1 - 0.011 14.8 0.7 0.016 14.3 0.7 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 KOO27091.1 - 0.076 12.3 1.5 0.12 11.7 1.5 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 KOO27091.1 - 0.085 12.1 0.1 0.16 11.2 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pkinase PF00069.25 KOO27092.1 - 7.9e-22 77.9 0.0 1.4e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27092.1 - 2e-15 56.8 0.0 2.9e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1499 PF07386.11 KOO27093.1 - 1.4e-19 70.7 0.0 2.5e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1499) TAT_signal PF10518.9 KOO27093.1 - 7.2 6.6 8.1 0.59 10.1 3.0 1.9 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence EF-hand_6 PF13405.6 KOO27094.1 - 3.2e-89 285.3 53.1 1.6e-05 24.4 0.0 18.4 18 0 0 18 18 18 18 EF-hand domain EF-hand_1 PF00036.32 KOO27094.1 - 1.2e-87 281.1 71.2 2e-05 23.8 0.1 18.8 19 0 0 19 19 19 18 EF hand EF-hand_7 PF13499.6 KOO27094.1 - 5.6e-79 260.6 60.3 1.4e-09 38.2 0.4 11.0 6 2 7 13 13 13 13 EF-hand domain pair EF-hand_5 PF13202.6 KOO27094.1 - 4.1e-58 190.4 79.7 0.00042 19.7 0.3 18.5 18 0 0 18 18 18 16 EF hand EF-hand_8 PF13833.6 KOO27094.1 - 8.3e-55 182.5 78.4 0.00011 21.9 2.2 17.9 7 6 11 18 18 18 18 EF-hand domain pair EF-hand_10 PF14788.6 KOO27094.1 - 7.2e-11 41.8 20.8 0.24 11.3 0.1 11.9 10 2 2 12 12 12 2 EF hand SPARC_Ca_bdg PF10591.9 KOO27094.1 - 4.3e-09 36.7 20.2 0.19 12.1 0.2 9.5 9 3 1 10 10 10 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO27094.1 - 3.3e-07 30.2 40.0 0.048 13.6 0.5 10.2 8 3 2 11 11 11 3 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 KOO27094.1 - 6e-05 23.9 0.3 14 6.7 0.0 5.6 6 0 0 6 6 6 0 EF-hand domain Caleosin PF05042.13 KOO27094.1 - 0.00061 19.7 20.0 7.3 6.5 0.0 10.0 8 3 1 10 10 10 1 Caleosin related protein Armet PF10208.9 KOO27094.1 - 0.00087 19.2 2.1 10 6.1 0.1 5.6 6 0 0 6 6 6 0 Degradation arginine-rich protein for mis-folding DUF3872 PF12988.7 KOO27094.1 - 0.0009 19.1 0.2 2 8.3 0.0 2.9 3 0 0 3 3 3 2 Domain of unknown function, B. Theta Gene description (DUF3872) PIG-L PF02585.17 KOO27094.1 - 0.0017 19.0 0.5 40 4.8 0.0 5.7 3 3 3 6 6 6 0 GlcNAc-PI de-N-acetylase RST PF12174.8 KOO27094.1 - 0.0024 17.8 0.0 25 4.9 0.0 3.7 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain DUF357 PF04010.13 KOO27094.1 - 0.0083 16.2 0.1 19 5.4 0.0 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF357) HOIP-UBA PF16678.5 KOO27094.1 - 0.019 14.9 0.9 0.59 10.1 0.0 3.9 4 1 0 4 4 4 0 HOIP UBA domain pair DUF1965 PF09248.10 KOO27094.1 - 0.12 12.2 0.0 69 3.3 0.0 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1965) p25-alpha PF05517.12 KOO27094.1 - 0.19 11.9 14.7 0.37 10.9 0.0 6.0 8 1 1 9 9 8 0 p25-alpha VCBS PF13517.6 KOO27094.1 - 8.7 7.0 20.0 16 6.2 0.4 5.3 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Vint PF14623.6 KOO27095.1 - 4.5e-24 85.1 0.0 7.6e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 Hint-domain VWA_2 PF13519.6 KOO27095.1 - 2.2e-08 34.7 0.0 4.2e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 KOO27095.1 - 0.025 14.8 0.0 0.045 14.0 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF4486 PF14858.6 KOO27096.1 - 0.0097 14.4 2.6 0.01 14.3 0.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4486) OCRE PF17780.1 KOO27096.1 - 0.1 12.6 0.3 0.18 11.9 0.3 1.2 1 0 0 1 1 1 0 OCRE domain DUF4618 PF15397.6 KOO27096.1 - 3.7 6.9 6.7 4 6.8 2.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) SKA2 PF16740.5 KOO27096.1 - 6.6 6.6 12.5 4.5 7.1 0.1 3.2 2 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 EGF_2 PF07974.13 KOO27098.1 - 2e-30 104.8 201.8 2.1e-05 24.8 8.3 11.4 11 0 0 11 11 11 11 EGF-like domain EGF PF00008.27 KOO27098.1 - 1.3e-11 44.5 168.5 0.0026 18.0 6.3 10.9 11 0 0 11 11 11 9 EGF-like domain hEGF PF12661.7 KOO27098.1 - 1.4e-09 38.2 129.6 0.0016 19.0 4.3 12.0 11 0 0 11 11 11 8 Human growth factor-like EGF EGF_Tenascin PF18720.1 KOO27098.1 - 2.3e-05 24.3 175.7 0.0019 18.2 13.4 12.2 11 1 0 11 11 11 7 Tenascin EGF domain Bim_N PF06773.11 KOO27098.1 - 0.0017 18.0 0.7 0.0059 16.3 0.7 2.0 1 0 0 1 1 1 1 Bim protein N-terminus EGF_alliinase PF04863.13 KOO27098.1 - 0.0044 17.4 10.7 0.0044 17.4 10.7 12.6 6 5 5 11 11 11 2 Alliinase EGF-like domain DUF599 PF04654.12 KOO27098.1 - 1.3 8.4 3.3 2.6 7.4 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF599 Cofilin_ADF PF00241.20 KOO27099.1 - 1.8e-31 108.5 0.0 1.2e-16 60.7 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein PCIF1_WW PF12237.8 KOO27100.1 - 9.5e-52 175.1 0.0 1.5e-51 174.4 0.0 1.3 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain TPT PF03151.16 KOO27101.1 - 2.9e-06 26.8 18.8 3.8e-06 26.5 18.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO27101.1 - 1.8e-05 24.9 29.7 0.00011 22.4 9.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family Inositol_P PF00459.25 KOO27102.1 - 1.6e-44 152.5 0.0 2.7e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family GxGYxYP_C PF14323.6 KOO27102.1 - 6.5e-17 62.2 0.2 1.9e-16 60.7 0.2 1.8 1 1 0 1 1 1 1 GxGYxYP putative glycoside hydrolase C-terminal domain Caps_synth PF05704.12 KOO27102.1 - 3e-10 40.0 0.0 5.8e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein GxGYxYP_N PF16216.5 KOO27102.1 - 7.7e-09 36.0 0.0 1.8e-08 34.9 0.0 1.6 1 1 0 1 1 1 1 GxGYxY sequence motif in domain of unknown function N-terminal Gly_transf_sug PF04488.15 KOO27102.1 - 0.00021 21.9 0.0 0.00048 20.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TALPID3 PF15324.6 KOO27103.1 - 0.0021 15.9 4.7 0.0025 15.6 4.7 1.0 1 0 0 1 1 1 1 Hedgehog signalling target DUF1664 PF07889.12 KOO27103.1 - 0.38 10.8 1.5 0.53 10.3 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) RCC_reductase PF06405.11 KOO27105.1 - 0.036 13.3 0.0 0.059 12.5 0.0 1.3 1 0 0 1 1 1 0 Red chlorophyll catabolite reductase (RCC reductase) WGR PF05406.15 KOO27106.1 - 2.1e-22 79.0 1.1 4.5e-22 77.9 1.1 1.6 1 0 0 1 1 1 1 WGR domain Ank_2 PF12796.7 KOO27106.1 - 1.6e-07 31.8 0.0 1.9e-05 25.1 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO27106.1 - 4.2e-07 30.1 0.0 8.4e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO27106.1 - 1.2e-05 25.8 0.0 8.2e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27106.1 - 0.00013 22.1 0.0 0.00099 19.4 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 KOO27106.1 - 0.00038 20.8 0.0 0.015 15.8 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat PDEase_I PF00233.19 KOO27107.1 - 1e-64 218.6 0.0 1.3e-64 218.2 0.0 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Aldo_ket_red PF00248.21 KOO27112.1 - 1.8e-31 109.5 0.0 7e-30 104.2 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Vasohibin PF14822.6 KOO27113.1 - 2.6e-65 220.1 0.0 6.7e-65 218.7 0.0 1.5 1 1 1 2 2 2 1 Vasohibin EF-hand_1 PF00036.32 KOO27114.1 - 1.9e-08 33.3 0.1 0.0081 15.6 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO27114.1 - 3.1e-08 33.9 0.5 1.1e-07 32.2 0.5 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO27114.1 - 3.7e-06 26.7 0.7 0.12 12.3 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO27114.1 - 7.3e-06 25.5 0.1 0.0054 16.6 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO27114.1 - 5.7e-05 22.4 0.1 0.012 15.1 0.0 2.6 2 0 0 2 2 2 1 EF hand TPR_2 PF07719.17 KOO27114.1 - 0.019 15.1 23.1 0.12 12.6 0.6 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27114.1 - 0.058 14.1 0.1 0.058 14.1 0.1 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO27114.1 - 0.085 12.6 0.1 0.085 12.6 0.1 3.0 4 0 0 4 4 4 0 TPR repeat EF-hand_4 PF12763.7 KOO27114.1 - 0.2 11.6 0.3 2.6 8.0 0.0 2.3 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF630 PF04783.12 KOO27114.1 - 0.33 11.1 5.6 11 6.3 0.2 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF630) TPR_6 PF13174.6 KOO27114.1 - 1.1 10.1 9.8 1.1 10.1 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Baculo_PEP_C PF04513.12 KOO27115.1 - 0.44 10.6 9.5 7.4 6.6 0.2 4.2 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus TetR_C_15 PF17918.1 KOO27116.1 - 1.2 10.0 14.2 3.3 8.5 0.2 3.7 2 2 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain DUF998 PF06197.13 KOO27117.1 - 0.065 12.8 0.8 0.5 9.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF998) SIR2 PF02146.17 KOO27118.1 - 1.4e-23 83.8 0.0 1.8e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF2383 PF09537.10 KOO27119.1 - 0.12 12.7 0.2 0.14 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) DUF3287 PF11690.8 KOO27120.1 - 5.8 6.7 9.6 3.7 7.3 0.6 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF3287) DUF1116 PF06545.11 KOO27122.1 - 9e-71 237.7 0.0 1.4e-70 237.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1116) Isochorismatase PF00857.20 KOO27122.1 - 3e-37 128.5 0.0 5.9e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family Catalase_C PF18011.1 KOO27122.1 - 0.14 11.8 0.1 0.3 10.7 0.1 1.4 1 0 0 1 1 1 0 C-terminal domain found in long catalases Pkinase PF00069.25 KOO27125.1 - 9.1e-51 172.7 0.0 1.1e-50 172.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27125.1 - 6.1e-18 65.0 0.0 8.3e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO27125.1 - 1.4e-09 37.7 0.2 0.00058 19.3 0.1 2.9 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 KOO27125.1 - 8.3e-06 25.9 3.4 2.8e-05 24.2 0.3 2.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO27125.1 - 0.00029 19.7 0.0 0.00051 18.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 KOO27125.1 - 0.0026 17.3 0.0 0.0046 16.5 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 KOO27125.1 - 0.0069 16.0 0.0 0.0097 15.5 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 KOO27125.1 - 0.0081 15.5 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family QslA_E PF18226.1 KOO27125.1 - 0.092 12.7 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 LasR-specific antiactivator QslA chain E Ion_trans PF00520.31 KOO27126.1 - 0.00026 20.3 0.1 0.00038 19.8 0.1 1.1 1 0 0 1 1 1 1 Ion transport protein TMF_TATA_bd PF12325.8 KOO27126.1 - 0.012 15.8 7.9 0.012 15.8 7.9 3.4 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Phage_GP20 PF06810.11 KOO27126.1 - 0.017 14.9 2.2 0.017 14.9 2.2 2.6 2 0 0 2 2 2 0 Phage minor structural protein GP20 OmpH PF03938.14 KOO27126.1 - 0.023 15.1 31.5 0.077 13.3 3.8 3.3 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) Spc7 PF08317.11 KOO27126.1 - 0.12 11.3 28.5 0.047 12.6 3.9 2.8 2 1 1 3 3 3 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 KOO27126.1 - 0.13 12.3 22.9 0.21 11.6 4.3 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 KOO27126.1 - 0.35 10.2 25.7 0.052 12.9 14.9 2.7 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Lectin_N PF03954.14 KOO27126.1 - 0.36 10.6 14.7 0.12 12.1 1.3 3.1 3 1 0 3 3 3 0 Hepatic lectin, N-terminal domain Cluap1 PF10234.9 KOO27126.1 - 0.62 9.4 22.3 0.36 10.2 1.8 2.3 2 0 0 2 2 2 0 Clusterin-associated protein-1 HMMR_N PF15905.5 KOO27126.1 - 9.1 5.6 19.6 0.69 9.3 10.3 2.2 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal TCTP PF00838.17 KOO27127.1 - 2.5e-15 57.2 0.0 7.2e-15 55.7 0.0 1.8 1 1 0 1 1 1 1 Translationally controlled tumour protein RT_RNaseH_2 PF17919.1 KOO27127.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase AP2 PF00847.20 KOO27129.1 - 5.2e-06 26.6 1.4 0.048 13.9 0.1 3.0 2 0 0 2 2 2 2 AP2 domain zf-MIZ PF02891.20 KOO27129.1 - 0.00044 19.9 2.2 0.00073 19.2 1.2 1.8 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KOO27129.1 - 0.54 10.1 2.0 1.7 8.5 2.0 1.9 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF3829 PF12889.7 KOO27130.1 - 0.085 12.3 3.6 0.034 13.6 1.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) DivIC PF04977.15 KOO27130.1 - 0.21 11.4 1.4 0.62 9.9 1.4 1.8 1 0 0 1 1 1 0 Septum formation initiator PPR_2 PF13041.6 KOO27131.1 - 3.6e-32 110.3 0.0 1.2e-05 25.4 0.0 7.8 3 3 6 9 9 9 9 PPR repeat family PPR PF01535.20 KOO27131.1 - 1.7e-27 93.7 0.2 0.0026 17.9 0.0 9.8 11 0 0 11 11 11 6 PPR repeat PPR_3 PF13812.6 KOO27131.1 - 1.1e-22 79.9 0.0 6.1e-08 32.6 0.0 5.2 4 2 2 6 6 6 3 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO27131.1 - 3.8e-18 65.6 2.7 8.6e-11 41.6 0.0 3.8 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 KOO27131.1 - 3.3e-14 52.3 0.0 0.03 14.0 0.0 8.7 9 1 0 9 9 9 3 PPR repeat ANAPC3 PF12895.7 KOO27131.1 - 2.5e-06 27.6 4.8 0.00063 19.9 0.1 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 KOO27131.1 - 0.00017 22.1 24.8 0.43 11.5 0.6 7.3 4 3 4 8 8 8 2 Tetratricopeptide repeat COX5A PF02284.16 KOO27131.1 - 0.00025 21.0 0.3 0.57 10.2 0.0 3.3 3 1 1 4 4 4 2 Cytochrome c oxidase subunit Va HrpB1_HrpK PF09613.10 KOO27131.1 - 0.00046 19.8 13.2 1.5 8.5 0.0 5.5 3 2 2 5 5 5 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_19 PF14559.6 KOO27131.1 - 0.037 14.6 18.4 4.6 7.8 0.9 5.9 5 1 2 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO27131.1 - 0.092 12.8 6.0 27 5.1 0.1 5.8 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO27131.1 - 0.69 10.3 17.5 2.5 8.4 0.3 5.7 6 2 0 6 6 6 0 Tetratricopeptide repeat AP2 PF00847.20 KOO27132.1 - 3e-12 46.6 24.3 0.0014 18.8 0.3 6.0 6 0 0 6 6 6 5 AP2 domain TRAM_LAG1_CLN8 PF03798.16 KOO27133.1 - 2.2e-17 63.4 18.0 2.7e-17 63.2 18.0 1.1 1 0 0 1 1 1 1 TLC domain Ribosomal_L37 PF08561.10 KOO27134.1 - 6.4e-12 46.1 7.7 4e-09 37.0 0.0 2.6 1 1 2 3 3 3 2 Mitochondrial ribosomal protein L37 Dymeclin PF09742.9 KOO27135.1 - 1.1e-102 344.5 0.0 1.3e-102 344.3 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 KOO27135.1 - 2.4e-06 26.0 0.1 6.9e-05 21.2 0.0 2.8 4 0 0 4 4 4 1 High-temperature-induced dauer-formation protein SseC PF04888.12 KOO27136.1 - 0.012 15.2 4.1 0.042 13.4 4.3 1.6 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Maf1 PF09174.10 KOO27136.1 - 0.19 11.9 0.4 0.73 10.0 0.1 1.8 1 1 1 2 2 2 0 Maf1 regulator CT_C_D PF02682.16 KOO27136.1 - 0.2 11.4 1.0 0.33 10.7 1.0 1.2 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D RE_MjaI PF09568.10 KOO27136.1 - 0.35 10.7 1.8 0.59 10.0 1.8 1.3 1 0 0 1 1 1 0 MjaI restriction endonuclease DUF1682 PF07946.14 KOO27136.1 - 0.48 9.6 2.8 0.8 8.8 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) YtxH PF12732.7 KOO27136.1 - 2.3 8.8 6.1 78 3.9 6.1 2.3 1 1 0 1 1 1 0 YtxH-like protein RRN3 PF05327.11 KOO27136.1 - 5.2 5.5 7.5 7.3 5.0 7.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Ribosomal_S9 PF00380.19 KOO27138.1 - 6.9e-30 104.1 0.1 7.9e-30 103.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ank_2 PF12796.7 KOO27139.1 - 3.8e-06 27.4 0.0 1.1e-05 26.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO27139.1 - 4.4e-05 23.7 0.1 0.004 17.5 0.1 3.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 KOO27139.1 - 0.00039 20.6 0.2 0.053 13.9 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27139.1 - 0.0025 18.2 0.0 0.8 10.5 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 KOO27139.1 - 0.023 15.3 0.1 0.36 11.5 0.0 2.6 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Fcf1 PF04900.12 KOO27141.1 - 1.5e-13 51.0 0.0 3e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Fcf1 PGAP1 PF07819.13 KOO27141.1 - 1.2e-07 31.7 0.0 2.1e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 KOO27141.1 - 0.0009 18.5 0.0 0.0013 18.0 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 KOO27141.1 - 0.0019 18.9 10.6 0.0019 18.9 10.6 2.8 2 1 1 3 3 3 1 Alpha/beta hydrolase family PIN_9 PF18477.1 KOO27141.1 - 0.0029 17.9 0.1 0.013 15.8 0.0 2.0 2 0 0 2 2 2 1 PIN like domain Abhydrolase_1 PF00561.20 KOO27141.1 - 0.003 17.2 0.0 0.0064 16.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold His_Phos_1 PF00300.22 KOO27141.1 - 0.018 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) Hydrolase_4 PF12146.8 KOO27141.1 - 0.029 13.6 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF676 PF05057.14 KOO27141.1 - 0.093 12.2 0.1 0.57 9.7 0.0 2.2 3 0 0 3 3 3 0 Putative serine esterase (DUF676) Palm_thioest PF02089.15 KOO27141.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Lipase_3 PF01764.25 KOO27141.1 - 0.13 12.1 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF3726 PF12525.8 KOO27141.1 - 0.14 12.2 0.2 5.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3726) GST_N PF02798.20 KOO27142.1 - 3.3e-12 46.6 0.0 8.4e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOO27142.1 - 9.1e-11 41.8 0.0 1.8e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOO27142.1 - 9.5e-06 25.9 0.0 1.9e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO27142.1 - 0.0023 18.2 0.0 0.0044 17.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain RPN1_C PF18051.1 KOO27144.1 - 1.3e-19 69.9 0.2 2.5e-19 69.0 0.2 1.4 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 KOO27144.1 - 0.022 15.2 1.3 5.4 7.6 0.1 3.3 3 0 0 3 3 3 0 Proteasome/cyclosome repeat TIMELESS_C PF05029.13 KOO27145.1 - 2.3 7.3 11.6 2.3 7.3 11.6 1.0 1 0 0 1 1 1 0 Timeless protein C terminal region Nuc_sug_transp PF04142.15 KOO27146.1 - 1.2e-46 159.4 6.3 1.4e-46 159.1 6.3 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 KOO27146.1 - 8.5e-07 28.5 6.3 1.1e-06 28.0 6.3 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO27146.1 - 0.00028 21.0 19.2 0.00032 20.9 2.8 2.6 3 0 0 3 3 3 2 EamA-like transporter family CRT-like PF08627.10 KOO27146.1 - 0.00037 19.6 0.1 0.00037 19.6 0.1 1.5 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 KOO27146.1 - 0.0051 16.4 0.2 0.0097 15.4 0.2 1.4 1 0 0 1 1 1 1 Solute carrier family 35 PUNUT PF16913.5 KOO27146.1 - 0.016 14.4 0.9 0.016 14.4 0.9 2.0 2 0 0 2 2 2 0 Purine nucleobase transmembrane transport TPT PF03151.16 KOO27146.1 - 0.018 14.4 0.5 0.018 14.4 0.5 2.4 1 1 1 2 2 2 0 Triose-phosphate Transporter family DUF4231 PF14015.6 KOO27146.1 - 0.41 11.2 6.4 2.6 8.6 0.3 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF4231) NHL PF01436.21 KOO27147.1 - 5.7e-24 82.9 17.4 2.1e-06 27.5 0.2 6.2 6 0 0 6 6 6 5 NHL repeat BTB PF00651.31 KOO27147.1 - 7.2e-12 45.5 0.0 1.4e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain SGL PF08450.12 KOO27147.1 - 1.5e-10 41.1 0.1 0.0045 16.6 0.0 4.4 3 1 1 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 KOO27147.1 - 0.0063 16.5 0.0 4.8 7.0 0.0 3.3 3 1 1 4 4 4 2 Esterase-like activity of phytase NOG1 PF06858.14 KOO27147.1 - 0.013 15.3 0.0 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) PQQ_3 PF13570.6 KOO27147.1 - 0.055 14.0 10.2 13 6.5 0.3 5.2 5 0 0 5 5 5 0 PQQ-like domain Ldl_recept_b PF00058.17 KOO27147.1 - 0.12 12.9 0.0 1.3e+02 3.1 0.0 4.2 5 0 0 5 5 5 0 Low-density lipoprotein receptor repeat class B NAD_binding_10 PF13460.6 KOO27149.1 - 2.4e-26 92.7 3.4 4e-23 82.3 1.8 3.6 2 1 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 KOO27149.1 - 0.021 14.4 0.0 0.099 12.2 0.0 2.0 1 1 0 1 1 1 0 NmrA-like family DAHP_synth_2 PF01474.16 KOO27150.1 - 2.5e-148 494.2 0.0 8.2e-148 492.5 0.0 1.7 1 1 0 1 1 1 1 Class-II DAHP synthetase family PhoLip_ATPase_N PF16209.5 KOO27151.1 - 1.5e-10 40.6 0.1 1.5e-10 40.6 0.1 1.9 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 KOO27151.1 - 4.5e-07 29.6 0.0 1.7e-06 27.7 0.0 1.8 1 1 0 1 1 1 1 E1-E2 ATPase LRR_6 PF13516.6 KOO27152.1 - 0.013 15.5 5.7 0.68 10.1 0.3 3.7 3 0 0 3 3 3 0 Leucine Rich repeat LRR_8 PF13855.6 KOO27152.1 - 0.2 11.4 1.1 1.9 8.3 0.0 3.0 4 0 0 4 4 4 0 Leucine rich repeat Glycos_transf_2 PF00535.26 KOO27153.1 - 5e-15 55.7 0.0 9.2e-15 54.9 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KOO27153.1 - 4.1e-07 30.1 0.8 6.6e-07 29.4 0.8 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KOO27153.1 - 0.01 16.4 0.0 0.021 15.3 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 SBD_N PF07005.11 KOO27153.1 - 0.016 15.0 0.1 0.031 14.0 0.1 1.5 1 0 0 1 1 1 0 Sugar-binding N-terminal domain LRR_6 PF13516.6 KOO27154.1 - 1.4e-34 115.2 40.3 5.7e-06 26.0 0.2 11.9 11 0 0 11 11 11 10 Leucine Rich repeat LRR_4 PF12799.7 KOO27154.1 - 1.9e-13 50.4 9.5 0.0014 19.0 0.2 6.1 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO27154.1 - 1.1e-05 25.1 22.5 0.6 9.9 1.7 7.4 5 2 0 6 6 6 4 Leucine rich repeat LRR_1 PF00560.33 KOO27154.1 - 6.4e-05 23.0 0.1 91 4.2 0.0 6.8 7 0 0 7 7 7 0 Leucine Rich Repeat RAG2 PF03089.14 KOO27154.1 - 0.064 12.2 0.0 2.8 6.8 0.0 2.3 1 1 1 2 2 2 0 Recombination activating protein 2 Peptidase_C41 PF05417.11 KOO27154.1 - 0.11 12.3 0.1 9.1 6.1 0.0 2.5 2 0 0 2 2 2 0 Hepatitis E cysteine protease WW PF00397.26 KOO27155.1 - 4.3e-11 42.7 1.6 7.8e-11 41.9 1.6 1.5 1 0 0 1 1 1 1 WW domain WW_1 PF18507.1 KOO27155.1 - 0.067 12.9 4.8 0.13 11.9 4.8 1.5 1 0 0 1 1 1 0 WW domain DctQ PF04290.12 KOO27155.1 - 0.24 11.3 3.8 0.38 10.7 3.8 1.3 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component SSF PF00474.17 KOO27156.1 - 2.5e-21 76.0 21.8 2.5e-15 56.3 12.2 2.2 2 0 0 2 2 2 2 Sodium:solute symporter family DUF3757 PF12582.8 KOO27156.1 - 0.27 11.6 1.0 0.39 11.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3757) DAO PF01266.24 KOO27157.1 - 1.6e-60 205.5 0.1 2.5e-60 204.9 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fer2_BFD PF04324.15 KOO27157.1 - 1.8e-12 47.4 2.8 1.8e-12 47.4 2.8 2.2 2 0 0 2 2 2 1 BFD-like [2Fe-2S] binding domain Lycopene_cycl PF05834.12 KOO27157.1 - 0.00023 20.4 0.5 0.0018 17.4 0.3 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 KOO27157.1 - 0.00037 20.7 0.2 0.00096 19.3 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOO27157.1 - 0.00098 18.4 0.0 0.0021 17.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 KOO27157.1 - 0.006 16.8 0.1 0.023 15.0 0.1 2.0 1 0 0 1 1 1 1 TrkA-N domain SO_alpha_A3 PF17806.1 KOO27157.1 - 0.0067 16.7 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 Sarcosine oxidase A3 domain FAD_binding_3 PF01494.19 KOO27157.1 - 0.028 13.6 1.1 0.11 11.7 0.3 2.0 2 0 0 2 2 2 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 KOO27157.1 - 0.041 14.1 0.2 0.1 12.9 0.2 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain HI0933_like PF03486.14 KOO27157.1 - 0.052 12.2 0.2 0.085 11.5 0.2 1.3 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 KOO27157.1 - 0.057 12.7 0.5 0.12 11.6 0.5 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 KOO27157.1 - 0.082 13.5 0.5 0.23 12.0 0.3 1.9 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 KOO27157.1 - 0.11 12.2 0.3 0.19 11.4 0.3 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 KOO27157.1 - 0.15 11.9 0.4 0.31 10.9 0.4 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AAA_6 PF12774.7 KOO27158.1 - 1.2e-116 389.2 0.0 2.5e-115 384.9 0.0 2.9 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO27158.1 - 1.2e-98 330.9 8.4 1.2e-98 330.9 8.4 2.5 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO27158.1 - 5.4e-95 317.6 0.0 3.2e-94 315.1 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KOO27158.1 - 6.5e-81 270.7 0.1 1.5e-80 269.4 0.1 1.7 1 0 0 1 1 1 1 ATP-binding dynein motor region Dynein_C PF18199.1 KOO27158.1 - 3e-64 217.2 0.0 6.8e-64 216.0 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain MT PF12777.7 KOO27158.1 - 1.1e-61 208.8 10.6 1.1e-61 208.8 10.6 1.6 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 KOO27158.1 - 6.8e-56 188.6 2.7 1.2e-54 184.6 0.1 3.5 5 0 0 5 5 5 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KOO27158.1 - 1.1e-47 161.8 0.1 1.6e-46 158.2 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO27158.1 - 1.3e-33 115.6 0.0 4.1e-33 114.0 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 KOO27158.1 - 3.1e-27 94.7 0.2 1.2e-26 92.8 0.2 2.1 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 KOO27158.1 - 3.2e-21 75.7 0.7 1e-20 74.1 0.5 2.1 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO27158.1 - 2.5e-17 63.2 0.0 1.5e-05 25.0 0.0 5.3 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA PF00004.29 KOO27158.1 - 0.0033 17.9 0.5 13 6.2 0.0 4.0 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO27158.1 - 0.0074 16.7 0.3 2.1 8.7 0.0 3.8 3 0 0 3 3 3 1 AAA ATPase domain LRR_5 PF13306.6 KOO27160.1 - 1.6e-17 63.6 0.0 2e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO27160.1 - 0.003 17.3 0.0 0.14 11.9 0.0 2.8 2 1 1 3 3 3 2 Leucine rich repeat DHC_N1 PF08385.12 KOO27161.1 - 1.1e-157 526.1 8.5 3.8e-156 521.0 0.0 4.2 2 1 1 4 4 4 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 KOO27161.1 - 9.6e-155 514.5 0.0 5e-154 512.1 0.0 2.1 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO27161.1 - 3.3e-108 362.3 4.5 3.3e-108 362.3 4.5 4.4 4 1 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 KOO27161.1 - 1.9e-44 151.3 0.0 1.4e-39 135.5 0.0 3.1 2 0 0 2 2 2 2 P-loop containing dynein motor region Dynein_AAA_lid PF17852.1 KOO27161.1 - 1.3e-25 90.0 0.1 5.8e-25 87.8 0.1 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO27161.1 - 5.9e-14 52.2 0.0 0.0025 17.8 0.0 4.3 3 1 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO27161.1 - 2e-06 28.3 0.1 0.039 14.3 0.0 3.9 2 1 1 3 3 3 2 AAA ATPase domain AAA PF00004.29 KOO27161.1 - 2e-05 25.1 0.0 0.35 11.3 0.0 3.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOO27161.1 - 0.00015 22.0 0.1 0.23 11.7 0.0 3.4 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOO27161.1 - 0.007 16.9 0.2 2.3 8.8 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 KOO27161.1 - 0.011 15.5 2.6 19 4.9 0.0 4.2 4 0 0 4 4 4 0 AAA domain DUF1376 PF07120.11 KOO27161.1 - 0.013 15.8 1.1 0.43 10.9 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1376) DUF853 PF05872.12 KOO27161.1 - 0.019 13.6 0.1 2.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) MSA-2c PF12238.8 KOO27161.1 - 0.082 12.9 0.2 0.26 11.2 0.2 1.8 1 0 0 1 1 1 0 Merozoite surface antigen 2c AAA_30 PF13604.6 KOO27161.1 - 0.17 11.6 1.4 2.2 8.0 0.0 3.0 4 0 0 4 4 4 0 AAA domain AAA_29 PF13555.6 KOO27161.1 - 0.24 11.2 0.5 2.1 8.2 0.0 2.6 3 0 0 3 3 3 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 KOO27161.1 - 0.28 11.6 2.1 5 7.6 0.0 4.0 5 0 0 5 5 5 0 RNA helicase REV1_C PF16727.5 KOO27161.1 - 0.9 10.0 4.4 1.2 9.5 0.2 3.4 3 0 0 3 3 3 0 DNA repair protein REV1 C-terminal domain FAA_hydro_N_2 PF18288.1 KOO27161.1 - 1.9 9.0 11.7 18 5.8 0.2 5.1 5 0 0 5 5 4 0 Fumarylacetoacetase N-terminal domain 2 DUF4951 PF16309.5 KOO27163.1 - 4.3 7.4 4.8 57 3.9 0.2 3.3 3 0 0 3 3 3 0 Domian of unknown function (DUF4951) Pepsin-I3 PF06394.13 KOO27164.1 - 0.37 11.0 4.5 26 5.1 0.3 3.6 3 0 0 3 3 3 0 Pepsin inhibitor-3-like repeated domain DUF896 PF05979.12 KOO27164.1 - 0.44 10.5 16.5 0.78 9.7 2.1 3.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF896) zf-HC2 PF13490.6 KOO27164.1 - 2.4 8.5 9.9 60 4.0 0.1 4.6 4 0 0 4 4 4 0 Putative zinc-finger SHOCT PF09851.9 KOO27164.1 - 3.1 7.7 18.1 0.22 11.3 0.4 4.6 4 0 0 4 4 4 0 Short C-terminal domain PspB PF06667.12 KOO27164.1 - 7 6.8 15.8 2.6 8.2 0.1 4.5 4 1 0 4 4 4 0 Phage shock protein B ABC_tran_CTD PF16326.5 KOO27164.1 - 9.1 6.6 32.7 1.7 8.9 0.4 5.1 3 2 1 4 4 4 0 ABC transporter C-terminal domain CTP_synth_N PF06418.14 KOO27167.1 - 1.1e-122 408.5 0.0 1.5e-122 408.0 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 KOO27167.1 - 3.8e-54 183.3 0.0 7.1e-54 182.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 KOO27167.1 - 2.9e-05 24.0 0.0 0.00013 21.8 0.0 2.1 2 1 0 2 2 2 1 Peptidase C26 CbiA PF01656.23 KOO27167.1 - 0.014 15.5 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2334 PF10096.9 KOO27167.1 - 0.066 12.8 0.0 1.5 8.4 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2334) MeaB PF03308.16 KOO27167.1 - 0.18 10.7 0.9 0.33 9.9 0.9 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Pyr_redox_2 PF07992.14 KOO27171.1 - 0.0004 19.7 0.0 0.00055 19.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO27171.1 - 0.0016 17.8 0.0 0.002 17.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOO27171.1 - 0.0079 15.8 1.1 0.013 15.1 0.9 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOO27171.1 - 0.018 15.3 2.1 0.025 14.8 0.2 2.4 2 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KOO27171.1 - 0.042 12.6 0.1 0.06 12.0 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein T2SSE_N PF05157.15 KOO27173.1 - 0.012 15.9 0.1 0.56 10.5 0.2 2.5 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein E, N-terminal domain Kelch_5 PF13854.6 KOO27173.1 - 0.025 14.5 0.1 0.065 13.2 0.1 1.7 2 0 0 2 2 2 0 Kelch motif TylF PF05711.11 KOO27174.1 - 5.3e-30 104.6 0.0 1e-29 103.6 0.0 1.5 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Cupin_8 PF13621.6 KOO27174.1 - 1.2e-09 38.3 0.0 5.6e-09 36.1 0.0 2.1 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 KOO27174.1 - 0.017 15.5 0.0 0.071 13.5 0.0 2.1 1 1 0 1 1 1 0 JmjC domain, hydroxylase TetR_C_11 PF16859.5 KOO27174.1 - 3.7 7.9 5.9 0.74 10.2 0.5 2.8 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain ABC_membrane PF00664.23 KOO27175.1 - 4.3e-39 134.8 2.5 5.3e-39 134.5 2.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOO27175.1 - 3.2e-34 118.4 0.0 5.5e-34 117.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOO27175.1 - 1.1e-07 31.5 0.2 4.3e-05 23.0 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOO27175.1 - 0.0021 17.9 2.0 0.2 11.5 0.0 2.2 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOO27175.1 - 0.0049 16.6 0.1 0.011 15.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.9 KOO27175.1 - 0.0058 15.5 0.4 0.026 13.3 0.1 1.9 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_30 PF13604.6 KOO27175.1 - 0.023 14.4 0.2 0.72 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO27175.1 - 0.037 14.4 6.2 0.057 13.8 2.0 3.2 3 1 0 3 3 3 0 AAA ATPase domain SbcCD_C PF13558.6 KOO27175.1 - 0.14 12.4 2.5 0.78 10.0 0.5 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 KOO27175.1 - 0.18 12.1 1.1 3 8.1 0.4 2.8 2 1 0 2 2 2 0 AAA domain UCH PF00443.29 KOO27177.1 - 6.7e-53 179.8 0.5 1.2e-52 179.0 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 KOO27177.1 - 1.2e-48 165.5 0.0 1e-47 162.5 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.8 KOO27177.1 - 1.8e-47 161.7 0.0 3.2e-47 160.9 0.0 1.4 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 KOO27177.1 - 2e-25 90.1 0.0 1.1e-24 87.6 0.0 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 KOO27177.1 - 6.3e-13 48.9 0.0 1.9e-12 47.4 0.0 1.9 1 0 0 1 1 1 1 MATH domain ubiquitin PF00240.23 KOO27177.1 - 0.00015 21.4 0.0 0.013 15.2 0.0 3.7 3 0 0 3 3 3 1 Ubiquitin family Ubiquitin_2 PF14560.6 KOO27177.1 - 0.0005 20.5 0.0 0.0019 18.6 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain PQ-loop PF04193.14 KOO27178.1 - 0.002 17.8 8.7 0.0023 17.7 0.2 3.5 3 1 1 4 4 4 2 PQ loop repeat ER_lumen_recept PF00810.18 KOO27178.1 - 0.1 13.4 2.8 0.11 13.3 1.8 1.7 1 1 0 1 1 1 0 ER lumen protein retaining receptor Dsh_C PF12316.8 KOO27179.1 - 0.35 11.2 1.6 0.63 10.4 1.6 1.5 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Baculo_PEP_C PF04513.12 KOO27179.1 - 1 9.4 9.0 0.34 10.9 0.8 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus YusW PF14039.6 KOO27179.1 - 4.7 7.8 8.2 1.8 9.1 3.4 2.5 2 0 0 2 2 2 0 YusW-like protein Glyco_transf_8 PF01501.20 KOO27180.1 - 0.039 13.5 0.0 0.05 13.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 8 DUF4386 PF14329.6 KOO27181.1 - 0.026 14.4 8.5 0.1 12.5 8.9 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4386) TB2_DP1_HVA22 PF03134.19 KOO27181.1 - 4.1 7.4 9.6 1.8 8.5 0.2 2.5 2 0 0 2 2 2 0 TB2/DP1, HVA22 family LRR_9 PF14580.6 KOO27183.1 - 1.1e-20 73.8 9.9 1.4e-18 67.0 2.5 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 KOO27183.1 - 1.7e-13 50.5 25.5 9.2e-07 29.1 2.4 3.8 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO27183.1 - 5.6e-08 32.4 18.8 3.9e-06 26.5 9.8 3.2 3 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 KOO27183.1 - 0.0031 17.4 9.4 0.15 12.2 0.5 3.8 4 0 0 4 4 4 2 Leucine Rich repeat XH PF03469.14 KOO27183.1 - 9 6.2 9.2 0.65 9.9 0.6 2.8 3 1 0 4 4 4 0 XH domain Bac_DNA_binding PF00216.21 KOO27184.1 - 0.37 11.0 6.3 1.1 9.5 0.2 2.9 2 1 1 3 3 3 0 Bacterial DNA-binding protein DUF768 PF05589.11 KOO27184.1 - 3.3 7.8 11.7 0.082 12.9 4.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF768) Pkinase_Tyr PF07714.17 KOO27185.1 - 6e-37 127.3 0.0 7.7e-37 127.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO27185.1 - 3.5e-32 111.8 0.0 5.2e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PP2C PF00481.21 KOO27185.1 - 7.6e-29 101.1 0.0 1.1e-28 100.6 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO27185.1 - 1.7e-05 24.9 0.4 0.014 15.3 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KOO27185.1 - 0.0038 16.9 0.3 0.034 13.8 0.3 2.1 2 0 0 2 2 2 1 Protein phosphatase 2C Pkinase_fungal PF17667.1 KOO27185.1 - 0.085 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase FAD_binding_3 PF01494.19 KOO27186.1 - 0.0055 16.0 0.1 0.034 13.4 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 KOO27186.1 - 0.039 13.2 0.2 0.16 11.2 0.0 2.1 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOO27186.1 - 0.19 12.0 2.2 0.27 11.5 0.1 2.5 2 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Arm PF00514.23 KOO27187.1 - 1.4e-22 78.9 0.3 3.6e-09 36.3 0.2 4.7 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO27187.1 - 2.6e-06 27.4 0.0 0.021 14.8 0.0 3.1 2 1 2 4 4 4 2 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 KOO27187.1 - 0.00043 20.3 0.7 0.39 11.1 0.0 3.8 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 KOO27187.1 - 0.00077 19.8 0.7 0.0017 18.7 0.7 1.6 1 0 0 1 1 1 1 HEAT repeats Arm_2 PF04826.13 KOO27187.1 - 0.00084 18.9 0.0 0.69 9.3 0.0 2.1 1 1 1 2 2 2 2 Armadillo-like CLASP_N PF12348.8 KOO27187.1 - 0.18 11.3 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 CLASP N terminal HEAT_EZ PF13513.6 KOO27187.1 - 0.59 10.7 3.5 7 7.3 0.2 3.0 2 1 1 3 3 3 0 HEAT-like repeat Arm PF00514.23 KOO27188.1 - 2.2e-28 97.4 7.8 1.3e-08 34.6 0.0 5.3 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO27188.1 - 0.027 15.0 9.6 23 5.6 0.0 4.5 2 2 2 4 4 4 0 HEAT-like repeat V-ATPase_H_N PF03224.14 KOO27188.1 - 0.069 12.4 0.0 0.096 12.0 0.0 1.1 1 0 0 1 1 1 0 V-ATPase subunit H WRNPLPNID PF15017.6 KOO27189.1 - 0.00014 22.7 0.6 0.77 10.7 0.0 2.2 2 0 0 2 2 2 2 Putative WW-binding domain and destruction box cobW PF02492.19 KOO27190.1 - 7.8e-55 185.2 4.2 1e-54 184.8 4.2 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KOO27190.1 - 8.8e-19 67.2 0.0 1.6e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 KOO27190.1 - 3.7e-06 26.9 0.1 0.018 14.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOO27190.1 - 0.00073 19.1 5.6 0.0046 16.5 5.4 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOO27190.1 - 0.00075 19.6 0.1 0.0025 17.9 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.6 KOO27190.1 - 0.0023 18.4 7.0 0.052 14.1 7.0 2.2 1 1 0 1 1 1 1 AAA domain MobB PF03205.14 KOO27190.1 - 0.003 17.5 0.2 0.0089 15.9 0.2 1.8 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 KOO27190.1 - 0.0048 16.8 0.2 0.013 15.4 0.0 1.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea Arf PF00025.21 KOO27190.1 - 0.0056 16.2 2.8 0.73 9.3 0.7 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_16 PF13191.6 KOO27190.1 - 0.0094 16.3 0.0 0.03 14.7 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 KOO27190.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 KOO27190.1 - 0.017 14.1 2.2 0.033 13.2 0.2 2.3 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NEL PF14496.6 KOO27190.1 - 0.039 13.4 0.2 0.064 12.7 0.2 1.2 1 0 0 1 1 1 0 C-terminal novel E3 ligase, LRR-interacting Viral_helicase1 PF01443.18 KOO27190.1 - 0.04 13.7 0.1 0.1 12.3 0.1 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 KOO27190.1 - 0.047 13.7 0.1 0.12 12.4 0.0 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRPRB PF09439.10 KOO27190.1 - 0.07 12.6 0.1 0.15 11.5 0.1 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_30 PF13604.6 KOO27190.1 - 0.078 12.7 0.1 0.18 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOO27190.1 - 0.096 13.0 0.0 0.24 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO27190.1 - 0.098 12.4 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SOG2 PF10428.9 KOO27190.1 - 0.1 11.8 0.2 0.18 11.0 0.2 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein AAA_14 PF13173.6 KOO27190.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOO27190.1 - 0.11 13.0 0.5 0.22 12.0 0.5 1.7 1 1 0 1 1 1 0 ABC transporter SRP54 PF00448.22 KOO27190.1 - 0.14 11.7 1.7 1 9.0 1.7 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain dNK PF01712.19 KOO27190.1 - 0.21 11.4 0.7 0.36 10.6 0.1 1.6 2 0 0 2 2 2 0 Deoxynucleoside kinase FAD_binding_1 PF00667.20 KOO27191.1 - 4.4e-34 118.0 0.0 5.8e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 KOO27191.1 - 1.2e-16 61.3 0.0 2.2e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOO27191.1 - 0.15 12.2 0.0 0.33 11.1 0.0 1.5 1 1 0 1 1 1 0 Ferric reductase NAD binding domain HTH_24 PF13412.6 KOO27191.1 - 0.16 11.6 0.0 8.6 6.0 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding PKcGMP_CC PF16808.5 KOO27192.1 - 0.00095 19.0 15.2 0.011 15.6 0.1 3.1 3 1 0 3 3 3 2 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4140 PF13600.6 KOO27192.1 - 0.023 15.1 5.9 0.039 14.4 5.9 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) ADIP PF11559.8 KOO27192.1 - 0.94 9.6 16.3 0.68 10.0 6.8 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Bap31_Bap29_C PF18035.1 KOO27192.1 - 3.1 7.9 7.6 5.5 7.1 0.6 2.4 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain TPR_12 PF13424.6 KOO27193.1 - 3.2e-80 264.5 43.0 1.8e-15 56.9 0.6 6.2 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 KOO27193.1 - 5.2e-77 251.9 26.1 1.1e-11 44.2 0.1 8.1 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO27193.1 - 1.3e-17 64.2 5.7 2.2e-11 43.8 1.4 2.4 1 1 1 2 2 2 2 MalT-like TPR region TPR_4 PF07721.14 KOO27193.1 - 2.3e-16 58.7 47.9 0.021 15.4 1.6 8.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 KOO27193.1 - 1.3e-15 56.4 1.2 1.2 9.1 0.0 7.2 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27193.1 - 1.8e-15 55.7 4.8 1.2 9.4 0.1 7.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO27193.1 - 2.3e-15 55.4 17.1 0.18 11.9 0.0 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27193.1 - 2.8e-13 48.9 0.7 2.5 8.5 0.0 7.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27193.1 - 3.7e-10 40.3 42.5 0.012 16.3 7.0 6.7 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOO27193.1 - 6.5e-10 39.0 36.1 0.13 13.2 0.4 7.4 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO27193.1 - 1e-07 32.3 28.0 0.021 15.3 3.4 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO27193.1 - 4.3e-06 26.7 7.0 9.3 6.9 0.0 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF4404 PF14357.6 KOO27193.1 - 0.00021 21.9 0.2 4.1 8.1 0.0 4.8 2 2 4 6 6 6 1 Domain of unknown function (DUF4404) FliG_M PF14841.6 KOO27193.1 - 0.0022 18.2 0.0 22 5.3 0.0 4.9 5 2 2 7 7 7 0 FliG middle domain UvsW PF11637.8 KOO27193.1 - 0.0094 16.0 5.7 6.2 7.0 0.0 5.5 7 0 0 7 7 5 1 ATP-dependant DNA helicase UvsW HisKA_3 PF07730.13 KOO27193.1 - 0.022 15.3 12.8 9.6 6.8 0.1 6.4 5 3 1 7 7 7 0 Histidine kinase TPR_3 PF07720.12 KOO27193.1 - 0.027 14.5 0.0 6.9 6.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO27193.1 - 0.14 12.4 0.0 1.5e+02 2.7 0.0 4.5 5 0 0 5 5 5 0 Osmosensory transporter coiled coil TPR_9 PF13371.6 KOO27193.1 - 0.27 11.4 23.2 19 5.5 0.3 6.5 1 1 6 7 7 7 0 Tetratricopeptide repeat DUF3426 PF11906.8 KOO27193.1 - 0.31 11.2 3.7 27 4.9 0.1 4.5 3 3 1 4 4 4 0 Protein of unknown function (DUF3426) Arm PF00514.23 KOO27194.1 - 4.7e-52 172.5 45.9 5.9e-06 26.1 0.2 15.4 15 1 0 15 15 15 13 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO27194.1 - 2.1e-10 40.5 2.0 0.0052 16.8 0.0 6.1 5 2 2 7 7 7 2 Spinocerebellar ataxia type 10 protein domain DUF5578 PF17741.1 KOO27194.1 - 1.9e-07 30.8 11.9 0.0068 15.9 0.1 4.9 1 1 2 5 5 5 3 Family of unknown function (DUF5578) Adaptin_N PF01602.20 KOO27194.1 - 8.4e-05 21.3 1.0 0.068 11.7 0.0 3.9 2 2 2 4 4 4 2 Adaptin N terminal region HEAT_2 PF13646.6 KOO27194.1 - 0.001 19.4 41.7 0.059 13.8 0.1 8.0 1 1 8 10 10 10 3 HEAT repeats V-ATPase_H_N PF03224.14 KOO27194.1 - 0.0041 16.4 0.1 0.79 8.9 0.1 3.4 1 1 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 KOO27194.1 - 0.0072 16.4 0.2 13 6.0 0.0 3.8 3 2 2 5 5 5 1 V-ATPase subunit H RICTOR_N PF14664.6 KOO27194.1 - 0.012 14.6 0.2 2.1 7.2 0.0 3.3 3 2 1 4 4 4 0 Rapamycin-insensitive companion of mTOR, N-term API5 PF05918.11 KOO27194.1 - 0.023 13.6 0.2 1 8.1 0.0 2.5 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) RasGEF_N_2 PF14663.6 KOO27194.1 - 0.22 11.9 6.6 64 4.0 0.0 5.8 5 1 1 6 6 6 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_EZ PF13513.6 KOO27194.1 - 0.93 10.1 40.0 0.057 13.9 3.0 8.9 8 2 3 11 11 11 0 HEAT-like repeat Kinesin PF00225.23 KOO27195.1 - 1.2e-103 346.6 0.1 3.8e-103 344.9 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOO27195.1 - 9.2e-26 90.6 0.0 2.3e-25 89.3 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding DnaJ PF00226.31 KOO27197.1 - 1.9e-22 79.1 0.3 4.6e-22 77.9 0.3 1.7 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.6 KOO27197.1 - 2e-09 37.2 0.0 2.7e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 X-domain of DnaJ-containing MSA-2c PF12238.8 KOO27197.1 - 1 9.3 6.9 1.8 8.5 6.9 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c ABC_membrane PF00664.23 KOO27198.1 - 2.2e-11 44.0 1.4 3.3e-11 43.4 0.9 1.7 1 1 0 1 1 1 1 ABC transporter transmembrane region Sod_Fe_C PF02777.18 KOO27198.1 - 0.19 11.9 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, C-terminal domain Cytochrom_C PF00034.21 KOO27199.1 - 5.5e-14 53.1 0.1 7.6e-14 52.6 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 KOO27199.1 - 2e-08 34.4 4.9 1.6e-07 31.6 4.9 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 KOO27199.1 - 0.0044 16.7 1.2 0.056 13.2 0.5 2.1 2 0 0 2 2 2 1 Cytochrome c-550 domain DUF1924 PF09086.11 KOO27199.1 - 0.19 12.1 1.6 0.93 9.9 0.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1924) Ribosomal_L7Ae PF01248.26 KOO27200.1 - 4.4e-24 84.0 1.3 6.2e-24 83.6 1.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 KOO27200.1 - 0.00029 20.9 0.0 0.00034 20.7 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 RNA_pol_Rpb4 PF03874.16 KOO27200.1 - 0.012 15.9 0.1 0.017 15.4 0.1 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb4 AP3D1 PF06375.11 KOO27200.1 - 0.2 11.9 5.7 0.38 11.0 5.7 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Cytomega_UL84 PF06284.11 KOO27200.1 - 0.71 8.3 5.2 0.87 8.0 5.2 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein EIF_2_alpha PF07541.12 KOO27201.1 - 1.8e-32 111.8 0.0 4.3e-32 110.6 0.0 1.6 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 KOO27201.1 - 1.1e-14 54.5 0.3 2.2e-14 53.5 0.3 1.5 1 0 0 1 1 1 1 S1 RNA binding domain EXOSC1 PF10447.9 KOO27201.1 - 0.0059 17.2 0.2 0.013 16.1 0.2 1.7 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 CENP-B_dimeris PF09026.10 KOO27201.1 - 0.014 15.8 0.8 0.014 15.8 0.8 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain zf-CCCH PF00642.24 KOO27202.1 - 1.4e-08 34.4 2.3 3.2e-08 33.3 2.3 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_5 PF14634.6 KOO27202.1 - 1.8e-06 27.8 11.2 2.9e-06 27.1 11.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOO27202.1 - 8e-06 25.6 9.7 1.5e-05 24.8 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO27202.1 - 3.3e-05 24.1 11.3 6e-05 23.3 11.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf_CCCH_4 PF18345.1 KOO27202.1 - 0.00013 21.9 4.8 0.00025 21.0 4.8 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-RING_10 PF16685.5 KOO27202.1 - 0.0012 18.9 5.6 0.0012 18.9 5.6 1.8 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf-RING_UBOX PF13445.6 KOO27202.1 - 0.0018 18.2 8.9 0.0039 17.2 8.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOO27202.1 - 0.0038 17.1 12.2 0.0071 16.2 12.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO27202.1 - 0.0052 16.6 11.4 0.01 15.7 11.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 KOO27202.1 - 0.0086 15.9 3.1 0.0086 15.9 3.1 2.1 2 0 0 2 2 2 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 KOO27202.1 - 0.083 13.4 2.3 0.16 12.5 2.3 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Prok-RING_4 PF14447.6 KOO27202.1 - 0.26 11.2 10.1 0.48 10.3 10.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KOO27202.1 - 0.32 11.2 7.5 1.2 9.3 7.7 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-P11 PF03854.14 KOO27202.1 - 0.57 9.9 7.1 1.2 8.9 7.1 1.4 1 0 0 1 1 1 0 P-11 zinc finger ARL2_Bind_BART PF11527.8 KOO27203.1 - 4.5e-17 62.2 0.0 3.6e-09 36.7 0.0 2.4 2 1 0 2 2 2 2 The ARF-like 2 binding protein BART AsnC_trans_reg2 PF17805.1 KOO27203.1 - 0.066 13.4 0.2 2.3 8.5 0.0 2.4 2 0 0 2 2 2 0 AsnC-like ligand binding domain Aa_trans PF01490.18 KOO27204.1 - 4.6e-19 68.4 2.3 5.7e-19 68.1 2.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Laminin_G_3 PF13385.6 KOO27205.1 - 0.0021 18.2 0.0 0.0038 17.4 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PKcGMP_CC PF16808.5 KOO27205.1 - 0.055 13.3 2.7 0.21 11.5 2.7 2.0 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF5601 PF18151.1 KOO27205.1 - 0.13 12.6 0.1 0.31 11.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) ABC_tran PF00005.27 KOO27207.1 - 1.3e-25 90.5 0.0 2e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOO27207.1 - 1.3e-08 34.8 0.5 1.9e-08 34.3 0.5 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 KOO27207.1 - 3.5e-06 26.6 0.0 0.00069 19.1 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 KOO27207.1 - 0.0051 16.9 0.0 0.019 15.0 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 KOO27207.1 - 0.018 14.7 0.0 0.044 13.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO27207.1 - 0.023 15.0 0.2 7.7 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 KOO27207.1 - 0.025 14.7 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_30 PF13604.6 KOO27207.1 - 0.026 14.3 0.0 0.091 12.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 KOO27207.1 - 0.053 13.3 0.2 1.9 8.2 0.1 2.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KOO27207.1 - 0.056 13.8 0.3 0.16 12.3 0.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 KOO27207.1 - 0.19 12.2 0.1 0.3 11.6 0.1 1.2 1 0 0 1 1 1 0 AAA domain TLD PF07534.16 KOO27209.1 - 7.8e-09 35.9 0.0 1e-08 35.5 0.0 1.1 1 0 0 1 1 1 1 TLD TPR_11 PF13414.6 KOO27210.1 - 5.1e-05 22.9 5.2 1.7 8.4 0.0 4.7 5 0 0 5 5 5 3 TPR repeat TPR_17 PF13431.6 KOO27210.1 - 6.9e-05 22.9 0.8 0.61 10.6 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27210.1 - 0.0057 16.8 0.3 0.0057 16.8 0.3 4.5 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO27210.1 - 0.0077 16.0 2.5 0.38 10.6 0.5 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27210.1 - 0.015 15.3 1.4 0.015 15.3 1.4 5.6 6 2 1 7 7 7 0 Tetratricopeptide repeat CCDC-167 PF15188.6 KOO27211.1 - 0.0018 18.6 11.5 0.0031 17.8 11.5 1.4 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 AAA_11 PF13086.6 KOO27211.1 - 0.012 15.4 1.8 0.015 15.1 1.8 1.2 1 0 0 1 1 1 0 AAA domain JAKMIP_CC3 PF16034.5 KOO27211.1 - 0.045 13.7 8.9 0.063 13.2 8.9 1.2 1 0 0 1 1 1 0 JAKMIP CC3 domain APG6_N PF17675.1 KOO27211.1 - 0.12 13.0 17.2 0.86 10.1 17.2 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region UPF0242 PF06785.11 KOO27211.1 - 0.15 12.2 8.8 0.22 11.6 8.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ERM PF00769.19 KOO27211.1 - 0.24 11.2 14.3 0.34 10.7 14.3 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DivIC PF04977.15 KOO27211.1 - 0.51 10.1 11.1 6.5 6.6 10.4 2.2 2 0 0 2 2 2 0 Septum formation initiator TMPIT PF07851.13 KOO27211.1 - 0.53 9.5 3.5 0.69 9.1 3.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein V_ATPase_I PF01496.19 KOO27211.1 - 0.67 7.8 4.8 0.88 7.4 4.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Seadorna_VP6 PF07407.11 KOO27211.1 - 0.69 8.8 4.5 0.96 8.3 4.5 1.2 1 0 0 1 1 1 0 Seadornavirus VP6 protein NuA4 PF09340.10 KOO27211.1 - 7.3 6.5 8.4 76 3.3 0.0 2.5 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 DUF4140 PF13600.6 KOO27211.1 - 9.2 6.8 9.2 57 4.2 9.2 2.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) ABM PF03992.16 KOO27212.1 - 1.1e-08 35.0 0.0 1.8e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase EF-hand_6 PF13405.6 KOO27213.1 - 2.4e-14 52.0 0.2 3e-05 23.6 0.0 3.6 3 1 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO27213.1 - 2.1e-12 45.7 1.1 4e-05 22.8 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KOO27213.1 - 5.1e-12 46.1 0.1 0.00011 22.6 0.1 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO27213.1 - 1.2e-06 28.2 4.8 0.0092 15.8 0.3 4.3 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 KOO27213.1 - 0.00017 21.8 0.0 0.26 11.6 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO27213.1 - 0.0011 18.4 0.0 1.6 8.4 0.0 3.4 3 0 0 3 3 3 2 EF hand SurA_N_2 PF13623.6 KOO27213.1 - 0.081 12.8 0.0 0.24 11.2 0.0 1.7 2 0 0 2 2 2 0 SurA N-terminal domain DUF5580 PF17743.1 KOO27213.1 - 0.094 11.2 0.0 0.18 10.3 0.0 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5580) Glutaredoxin PF00462.24 KOO27214.1 - 2e-09 37.5 0.0 3.4e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.6 KOO27214.1 - 0.11 12.8 0.1 0.3 11.4 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 KOO27214.1 - 0.12 12.8 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain EF-hand_7 PF13499.6 KOO27215.1 - 1.6e-16 60.5 4.0 1.1e-07 32.2 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO27215.1 - 9.3e-16 56.1 11.1 5.2e-07 28.8 0.5 4.6 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO27215.1 - 1.1e-15 56.1 6.9 0.0013 18.5 0.1 4.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KOO27215.1 - 2.3e-10 39.5 3.8 0.0065 15.9 0.6 4.0 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO27215.1 - 4e-09 36.2 8.6 2.6e-06 27.2 0.4 3.9 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO27215.1 - 5.6e-05 23.0 0.3 0.0034 17.3 0.1 2.7 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO27215.1 - 0.00019 21.7 0.0 0.29 11.5 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 KOO27216.1 - 1.4e-26 90.7 5.0 0.0027 17.1 0.2 6.7 6 0 0 6 6 6 6 EF hand EF-hand_1 PF00036.32 KOO27216.1 - 1.3e-24 83.9 0.0 0.00088 18.7 0.1 6.6 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO27216.1 - 9.6e-22 75.0 0.0 0.032 14.2 0.1 6.6 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.6 KOO27216.1 - 1.4e-13 51.0 0.0 0.0094 16.4 0.0 4.7 3 3 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO27216.1 - 2.7e-11 43.1 0.6 0.28 11.1 0.0 6.3 6 0 0 6 6 6 2 EF-hand domain pair Dockerin_1 PF00404.18 KOO27216.1 - 9e-06 25.8 8.3 0.35 11.1 0.4 5.2 3 1 2 5 5 5 3 Dockerin type I domain GPS PF01825.21 KOO27216.1 - 0.0054 17.2 0.1 0.012 16.2 0.1 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PDZ PF00595.24 KOO27216.1 - 0.023 15.1 0.1 0.067 13.6 0.1 1.8 1 0 0 1 1 1 0 PDZ domain PDZ_6 PF17820.1 KOO27216.1 - 0.14 12.0 0.0 0.37 10.7 0.0 1.8 1 0 0 1 1 1 0 PDZ domain Aminotran_5 PF00266.19 KOO27217.1 - 8.2e-24 84.2 0.0 2.3e-20 72.9 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Pkinase_Tyr PF07714.17 KOO27219.1 - 8.5e-44 149.8 0.0 1.3e-43 149.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO27219.1 - 9.6e-40 136.6 0.0 1.2e-30 106.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PP2C PF00481.21 KOO27219.1 - 9.2e-12 45.1 0.0 1.5e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Kdo PF06293.14 KOO27219.1 - 8.4e-05 22.0 0.0 0.00018 20.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO27219.1 - 0.00039 20.4 0.1 0.00039 20.4 0.1 2.5 3 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO27219.1 - 0.0041 16.0 0.0 0.0069 15.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO27219.1 - 0.0082 15.5 0.3 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like SpoIIE PF07228.12 KOO27219.1 - 0.024 14.6 0.3 0.72 9.7 0.1 2.7 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Pkinase PF00069.25 KOO27220.1 - 3e-27 95.6 0.0 3.7e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27220.1 - 8.4e-14 51.5 0.0 1.4e-13 50.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO27220.1 - 4.6e-08 32.2 0.0 5.9e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO27220.1 - 0.0056 16.6 0.0 0.012 15.6 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KOO27220.1 - 0.096 11.6 0.5 0.16 10.9 0.5 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_Tyr PF07714.17 KOO27221.1 - 8.8e-41 139.9 0.0 1e-40 139.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO27221.1 - 3.8e-38 131.4 0.0 4.5e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain MFS_1 PF07690.16 KOO27222.1 - 2.5e-11 43.1 33.1 2.5e-11 43.1 33.1 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Ank_2 PF12796.7 KOO27223.1 - 1.3e-30 105.8 8.3 5.4e-14 52.6 0.9 4.7 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO27223.1 - 2.7e-23 79.5 4.6 0.00046 20.4 0.0 7.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 KOO27223.1 - 5.4e-19 68.0 9.0 1.8e-06 28.1 0.2 7.0 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO27223.1 - 5.7e-19 68.2 1.2 1.5e-08 35.0 0.0 4.1 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO27223.1 - 1.2e-18 66.6 10.6 0.0003 21.1 0.0 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ion_trans PF00520.31 KOO27223.1 - 1.9e-15 56.8 8.0 3.6e-15 55.9 8.0 1.4 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO27223.1 - 2 7.0 10.5 9.6 4.8 8.5 2.3 2 1 0 2 2 2 0 Polycystin cation channel Tiam_CC_Ex PF18385.1 KOO27224.1 - 0.53 10.7 4.8 0.13 12.7 1.1 1.9 2 0 0 2 2 2 0 T-lymphoma invasion and metastasis CC-Ex domain Adaptin_binding PF10199.9 KOO27224.1 - 2.2 8.9 6.4 1.7 9.2 4.4 1.9 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 FAM76 PF16046.5 KOO27224.1 - 8.5 5.6 7.8 4.7 6.5 4.8 2.0 1 1 1 2 2 2 0 FAM76 protein Dpy-30 PF05186.13 KOO27226.1 - 0.059 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Dpy-30 motif MutS_V PF00488.21 KOO27227.1 - 1.5e-71 240.3 0.2 4.1e-71 238.9 0.2 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KOO27227.1 - 4.9e-35 121.5 0.1 1e-34 120.4 0.1 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 KOO27227.1 - 1.3e-34 118.8 0.0 2.9e-34 117.7 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 KOO27227.1 - 8.4e-09 35.7 0.0 1.9e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 KOO27227.1 - 4.1e-08 33.6 0.0 8.5e-07 29.3 0.0 2.8 3 0 0 3 3 3 1 MutS domain II AAA_29 PF13555.6 KOO27227.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 KOO27227.1 - 5.3 7.4 7.3 3.6 7.9 0.1 3.6 3 1 0 3 3 3 0 AAA ATPase domain DUF2057 PF09829.9 KOO27230.1 - 0.1 12.8 1.5 0.18 11.9 1.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Abhydrolase_2 PF02230.16 KOO27231.1 - 0.021 14.6 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KOO27231.1 - 0.079 12.4 0.1 8.5 5.8 0.0 2.3 1 1 1 2 2 2 0 Prolyl oligopeptidase family Prenyltrans PF00432.21 KOO27232.1 - 8.5e-28 95.8 21.1 2.7e-08 33.4 0.3 6.6 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 KOO27232.1 - 0.011 14.8 0.1 0.15 11.1 0.0 2.5 2 1 1 3 3 3 0 Squalene-hopene cyclase N-terminal domain DnaJ PF00226.31 KOO27233.1 - 1.8e-22 79.2 0.3 2.9e-22 78.6 0.3 1.3 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.9 KOO27233.1 - 7.3e-13 48.8 3.0 1.2e-07 31.7 0.4 2.8 1 1 0 2 2 2 2 Transmembrane Fragile-X-F protein FOXP-CC PF16159.5 KOO27234.1 - 0.0064 17.1 0.1 7.5 7.3 0.0 2.7 3 0 0 3 3 3 2 FOXP coiled-coil domain Tim44 PF04280.15 KOO27234.1 - 0.012 15.7 0.0 4.1 7.5 0.0 2.5 2 1 0 2 2 2 0 Tim44-like domain FeoB_Cyto PF17910.1 KOO27234.1 - 0.052 14.1 5.1 2 9.0 0.7 2.2 2 0 0 2 2 2 0 FeoB cytosolic helical domain HTH_43 PF09904.9 KOO27234.1 - 0.075 13.0 0.0 3.8 7.5 0.0 2.8 2 2 1 3 3 3 0 Winged helix-turn helix RSRP PF17069.5 KOO27234.1 - 0.51 9.9 4.2 2.5 7.6 0.9 2.0 1 1 1 2 2 2 0 Arginine/Serine-Rich protein 1 Bestrophin PF01062.21 KOO27235.1 - 2e-30 106.2 0.2 2.6e-30 105.9 0.2 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel EF-hand_5 PF13202.6 KOO27235.1 - 0.00073 18.9 0.2 0.0015 18.0 0.2 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO27235.1 - 0.014 14.9 0.0 0.034 13.7 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 KOO27235.1 - 0.062 13.3 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 KOO27235.1 - 0.16 12.4 0.2 0.39 11.2 0.2 1.5 1 0 0 1 1 1 0 EF-hand domain pair Popeye PF04831.13 KOO27236.1 - 0.00049 20.3 0.0 0.0007 19.8 0.0 1.2 1 0 0 1 1 1 1 Popeye protein conserved region DSHCT PF08148.12 KOO27236.1 - 0.045 13.4 0.0 0.097 12.3 0.0 1.5 1 1 0 1 1 1 0 DSHCT (NUC185) domain FAM35_C PF15793.5 KOO27236.1 - 0.073 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein family FAM35, C-terminal Cnn_1N PF07989.11 KOO27236.1 - 0.084 13.0 0.2 0.18 12.0 0.2 1.4 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 UIM PF02809.20 KOO27236.1 - 0.67 10.0 3.3 6.8 6.9 0.1 3.0 2 0 0 2 2 2 0 Ubiquitin interaction motif Aldo_ket_red PF00248.21 KOO27238.1 - 5.8e-65 219.4 0.0 6.6e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PHBC_N PF12551.8 KOO27238.1 - 0.043 13.6 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase N terminal V_ATPase_prox PF18274.1 KOO27238.1 - 0.053 13.5 0.0 0.46 10.5 0.0 2.3 2 0 0 2 2 2 0 Vacuolar ATPase Subunit I N-terminal proximal lobe Corona_RPol_N PF06478.13 KOO27238.1 - 0.085 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Coronavirus RPol N-terminus Baculo_LEF5_C PF11792.8 KOO27238.1 - 0.11 12.2 0.2 0.28 10.9 0.0 1.7 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain Iso_dh PF00180.20 KOO27239.1 - 6.1e-22 78.2 0.0 1.2e-21 77.3 0.0 1.5 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase EF-hand_1 PF00036.32 KOO27239.1 - 8.4e-07 28.1 0.2 2.2e-06 26.8 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO27239.1 - 3.1e-06 26.7 0.0 1.2e-05 24.8 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO27239.1 - 3.4e-05 23.1 0.4 7.1e-05 22.1 0.4 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO27239.1 - 0.00054 20.4 0.0 0.0013 19.1 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair KORA PF16509.5 KOO27239.1 - 0.021 15.1 0.0 0.07 13.4 0.0 1.8 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor EF-hand_8 PF13833.6 KOO27239.1 - 0.059 13.2 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair Abhydrolase_3 PF07859.13 KOO27240.1 - 0.00096 19.1 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Myb_DNA-binding PF00249.31 KOO27241.1 - 6.1e-20 71.1 7.5 6e-11 42.4 1.9 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO27241.1 - 1.2e-19 70.3 8.9 6.1e-14 52.0 4.7 3.3 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_Cef PF11831.8 KOO27241.1 - 2.8e-16 59.8 0.0 2.8e-16 59.8 0.0 3.5 3 0 0 3 3 3 1 pre-mRNA splicing factor component Rap1_C PF11626.8 KOO27241.1 - 0.014 15.5 0.3 0.085 13.0 0.3 2.4 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain DpnI_C PF17726.1 KOO27241.1 - 0.57 10.3 2.5 3.8 7.7 0.2 2.4 2 0 0 2 2 2 0 Dam-replacing HTH domain MORN PF02493.20 KOO27242.1 - 5.4e-18 63.7 14.8 7e-06 25.6 2.0 3.6 3 0 0 3 3 3 3 MORN repeat DUF3048_C PF17479.2 KOO27242.1 - 0.019 15.4 1.7 0.29 11.5 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3048) C-terminal domain Agenet PF05641.12 KOO27244.1 - 2.1e-09 37.7 3.3 5.6e-06 26.7 0.0 5.0 4 0 0 4 4 4 1 Agenet domain SNF2_N PF00176.23 KOO27244.1 - 2.8e-09 36.2 0.3 0.00013 20.9 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Chromo PF00385.24 KOO27244.1 - 2e-08 34.0 0.3 5.6e-08 32.6 0.3 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 KOO27244.1 - 6.1e-08 32.4 0.8 6.1e-08 32.4 0.8 2.8 2 1 0 2 2 2 1 PHD-finger C1_2 PF03107.16 KOO27244.1 - 1.2e-05 25.5 9.0 2e-05 24.8 2.0 2.7 2 0 0 2 2 2 1 C1 domain C1_1 PF00130.22 KOO27244.1 - 0.0015 18.3 4.4 0.45 10.4 0.5 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) ZZ PF00569.17 KOO27244.1 - 0.0072 16.1 1.7 0.023 14.5 1.7 1.9 1 0 0 1 1 1 1 Zinc finger, ZZ type zf-PHD-like PF15446.6 KOO27244.1 - 0.01 15.5 0.8 0.034 13.8 0.8 1.9 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain FANCL_C PF11793.8 KOO27244.1 - 0.011 15.8 0.3 0.026 14.7 0.3 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain zf-HC5HC2H PF13771.6 KOO27244.1 - 0.019 15.2 1.9 0.02 15.1 0.0 2.0 2 0 0 2 2 2 0 PHD-like zinc-binding domain Prok-RING_1 PF14446.6 KOO27244.1 - 0.2 11.6 13.8 0.032 14.1 3.5 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 IBR PF01485.21 KOO27244.1 - 1.6 9.0 8.8 0.12 12.6 1.5 2.6 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain PALP PF00291.25 KOO27245.1 - 8.1e-62 209.3 0.0 1e-61 209.0 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme HAUS4 PF14735.6 KOO27247.1 - 0.33 10.6 4.6 0.42 10.3 4.6 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 DUF1682 PF07946.14 KOO27247.1 - 8.5 5.5 11.8 8.4 5.5 11.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) ADK PF00406.22 KOO27248.1 - 4.4e-25 88.5 0.0 7.7e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO27248.1 - 1.3e-12 48.3 0.0 5.1e-12 46.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF4743 PF15916.5 KOO27248.1 - 1.9e-07 31.1 0.0 2.8e-06 27.3 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 KOO27248.1 - 7.8e-06 26.0 0.0 2.6e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain DUF411 PF04214.13 KOO27248.1 - 0.14 12.1 0.1 0.33 10.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF PfkB PF00294.24 KOO27250.1 - 5.4e-41 140.9 0.1 6.6e-41 140.6 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Metallophos PF00149.28 KOO27251.1 - 2.9e-05 24.7 0.0 6.1e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO27251.1 - 0.0017 18.6 0.0 0.015 15.5 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Cupin_8 PF13621.6 KOO27252.1 - 8.4e-12 45.3 1.0 1e-10 41.8 0.1 2.3 2 1 1 3 3 3 2 Cupin-like domain Cupin_4 PF08007.12 KOO27252.1 - 0.0095 15.4 0.4 0.029 13.9 0.1 1.7 2 0 0 2 2 2 1 Cupin superfamily protein Ion_trans PF00520.31 KOO27253.1 - 1e-198 656.9 44.7 1.4e-57 194.8 0.1 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO27253.1 - 3.9e-07 29.7 0.0 9.6e-07 28.5 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO27253.1 - 2e-05 23.4 4.8 2e-05 23.4 4.8 9.5 7 4 4 11 11 11 4 Polycystin cation channel Metallophos PF00149.28 KOO27254.1 - 9.3e-30 104.7 0.0 1.3e-29 104.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOO27254.1 - 1.6e-05 25.3 0.0 3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Pheromone PF08015.11 KOO27254.1 - 5.7 8.1 0.0 5.7 8.1 0.0 3.5 3 1 0 3 3 3 0 Fungal mating-type pheromone Nuc_sug_transp PF04142.15 KOO27257.1 - 4e-81 272.6 5.6 4.6e-81 272.4 5.6 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO27257.1 - 1.2e-06 28.8 1.3 1.2e-06 28.8 1.3 2.5 2 1 0 2 2 2 1 EamA-like transporter family PUNUT PF16913.5 KOO27257.1 - 1e-05 24.9 2.2 1e-05 24.9 2.2 2.2 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport UAA PF08449.11 KOO27257.1 - 0.0013 18.0 0.1 0.0028 16.9 0.1 1.5 1 0 0 1 1 1 1 UAA transporter family CRT-like PF08627.10 KOO27257.1 - 0.009 15.0 0.7 0.016 14.2 0.7 1.3 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 KOO27257.1 - 0.013 14.9 1.6 0.013 14.9 1.6 1.9 1 1 0 2 2 2 0 Triose-phosphate Transporter family Multi_Drug_Res PF00893.19 KOO27257.1 - 1 10.1 15.6 2.1 9.1 0.3 3.8 3 2 1 4 4 4 0 Small Multidrug Resistance protein HlyIII PF03006.20 KOO27257.1 - 1.3 8.7 5.0 1.1 8.9 0.7 2.2 2 0 0 2 2 2 0 Haemolysin-III related HECT PF00632.25 KOO27258.1 - 0.01 15.4 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) TPR_9 PF13371.6 KOO27259.1 - 0.015 15.4 0.1 0.87 9.8 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Ank_2 PF12796.7 KOO27260.1 - 3.1e-50 168.7 10.8 3.5e-10 40.3 0.0 5.6 3 1 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO27260.1 - 2.5e-49 165.0 18.5 3.6e-08 33.8 0.1 9.7 5 3 6 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27260.1 - 6.4e-34 112.2 13.8 0.0006 20.1 0.0 11.3 12 0 0 12 12 12 8 Ankyrin repeat Ank_5 PF13857.6 KOO27260.1 - 2.1e-27 94.8 17.7 5.4e-06 26.6 0.6 7.7 6 2 1 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 KOO27260.1 - 7.7e-23 79.9 24.2 0.0056 17.1 0.2 9.6 10 0 0 10 10 10 6 Ankyrin repeat Gag_p10 PF02337.17 KOO27260.1 - 0.079 12.9 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Retroviral GAG p10 protein TPR_7 PF13176.6 KOO27260.1 - 0.1 12.7 0.0 2.1 8.6 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO27260.1 - 0.16 12.8 6.2 4.2 8.4 0.1 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27260.1 - 0.39 10.9 2.1 7.2 7.0 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27260.1 - 4.8 7.9 13.9 0.9 10.2 0.3 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat tRNA-synt_1b PF00579.25 KOO27261.1 - 2.6e-18 66.4 0.0 1.1e-17 64.4 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) LRR_6 PF13516.6 KOO27263.1 - 2.2e-26 89.6 16.1 2.7e-06 27.0 0.0 8.9 10 0 0 10 10 10 5 Leucine Rich repeat Ank_2 PF12796.7 KOO27263.1 - 7e-13 49.0 1.0 4.5e-10 40.0 0.1 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO27263.1 - 4.5e-12 46.0 0.7 1.5e-10 41.1 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO27263.1 - 4.9e-12 45.7 0.1 3.1e-06 27.4 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KOO27263.1 - 7.7e-09 35.9 0.7 5e-06 27.0 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27263.1 - 7.9e-07 28.9 0.1 0.0069 16.8 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat LRR_4 PF12799.7 KOO27263.1 - 0.003 17.9 5.2 6.6 7.3 0.0 5.1 4 2 2 6 6 5 1 Leucine Rich repeats (2 copies) EIF_2_alpha PF07541.12 KOO27263.1 - 0.0073 16.4 0.3 1.1 9.3 0.0 3.4 3 0 0 3 3 3 1 Eukaryotic translation initiation factor 2 alpha subunit LRR_1 PF00560.33 KOO27263.1 - 0.038 14.5 0.0 1.3e+02 3.8 0.0 5.5 7 0 0 7 7 6 0 Leucine Rich Repeat SpoU_sub_bind PF08032.12 KOO27263.1 - 0.069 13.4 7.8 0.098 12.9 0.3 4.2 4 1 1 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding HOASN PF14515.6 KOO27263.1 - 0.34 11.3 14.4 12 6.3 1.1 5.5 3 2 2 5 5 5 0 Haem-oxygenase-associated N-terminal helices Arm-DNA-bind_1 PF09003.10 KOO27263.1 - 0.82 9.9 9.0 7.8 6.7 0.1 3.7 3 1 1 4 4 4 0 Bacteriophage lambda integrase, Arm DNA-binding domain FAM25 PF15825.5 KOO27263.1 - 2.9 8.3 23.3 36 4.8 0.3 6.2 4 2 2 6 6 6 0 FAM25 family SET PF00856.28 KOO27264.1 - 1.8e-15 57.8 1.6 6.3e-15 56.0 0.3 2.3 2 1 0 2 2 2 1 SET domain Y2_Tnp PF04986.13 KOO27264.1 - 0.011 15.8 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 0 Putative transposase FKBP_C PF00254.28 KOO27266.1 - 3.4e-31 107.4 0.0 4.9e-31 106.9 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FlaC_arch PF05377.11 KOO27268.1 - 3.2 8.2 6.8 22 5.5 0.9 4.0 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) UPF0184 PF03670.13 KOO27268.1 - 8.6 6.8 8.3 4.9 7.6 0.5 3.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) YjbT PF17089.5 KOO27269.1 - 0.055 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family Beach PF02138.18 KOO27270.1 - 4.7e-119 396.8 0.0 6.5e-119 396.4 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain DUF4704 PF15787.5 KOO27270.1 - 1.2e-11 44.4 0.0 2e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4704) PH_BEACH PF14844.6 KOO27270.1 - 3e-10 40.1 0.0 2.1e-09 37.4 0.0 2.2 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.32 KOO27270.1 - 1.4e-05 25.7 0.2 0.66 10.9 0.1 4.4 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF1088 PF06469.11 KOO27270.1 - 0.0024 17.6 0.1 0.0045 16.7 0.1 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) TFIIA PF03153.13 KOO27271.1 - 9.7 6.1 18.5 11 5.9 18.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.32 KOO27272.1 - 1.7e-10 41.3 6.8 0.00016 22.4 0.3 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO27272.1 - 6.3e-07 29.6 0.5 0.17 12.2 0.0 3.7 2 2 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain 2Fe-2S_thioredx PF01257.19 KOO27272.1 - 0.0062 16.4 2.4 0.02 14.7 2.4 1.9 1 1 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin PALB2_WD40 PF16756.5 KOO27272.1 - 0.041 12.8 0.4 0.082 11.8 0.4 1.5 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain Astro_capsid_p PF12226.8 KOO27272.1 - 5.6 6.0 7.3 9.2 5.3 7.3 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TPR_12 PF13424.6 KOO27273.1 - 6e-111 362.9 60.3 4.1e-17 62.3 0.2 10.6 4 2 8 12 12 12 10 Tetratricopeptide repeat TPR_10 PF13374.6 KOO27273.1 - 1.4e-109 355.4 64.5 1.4e-11 43.9 0.0 15.9 16 2 1 17 17 16 13 Tetratricopeptide repeat TPR_1 PF00515.28 KOO27273.1 - 4.6e-39 130.7 7.8 0.004 16.9 0.0 11.3 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO27273.1 - 2.3e-36 125.9 17.0 1.3e-08 34.6 0.1 5.2 2 2 3 5 5 5 5 MalT-like TPR region TPR_4 PF07721.14 KOO27273.1 - 5.9e-33 110.1 13.1 0.014 16.0 0.1 12.4 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27273.1 - 7.1e-29 97.6 13.2 0.011 15.9 0.0 11.4 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27273.1 - 8.7e-29 97.3 20.6 0.035 14.2 0.1 11.8 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27273.1 - 2.3e-23 82.6 37.0 6.4e-05 23.5 1.7 9.7 5 4 4 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 KOO27273.1 - 2.4e-23 80.4 27.7 0.071 13.2 0.2 11.8 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_14 PF13428.6 KOO27273.1 - 3.2e-17 61.7 37.2 0.97 10.4 0.0 12.4 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO27273.1 - 1.6e-11 44.5 36.4 0.072 13.6 3.1 8.6 3 2 8 11 11 11 9 Tetratricopeptide repeat TPR_3 PF07720.12 KOO27273.1 - 1.1e-08 34.9 0.0 2.9 8.0 0.0 8.1 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO27273.1 - 5e-08 32.8 20.1 1.2 9.7 0.3 9.5 11 0 0 11 11 10 2 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO27273.1 - 5.9e-08 32.8 23.5 1.9 8.8 0.0 12.3 15 0 0 15 15 14 1 Osmosensory transporter coiled coil TPR_11 PF13414.6 KOO27273.1 - 0.0046 16.6 12.0 68 3.3 0.0 8.5 10 0 0 10 10 10 0 TPR repeat PPR_1 PF12854.7 KOO27273.1 - 0.36 10.6 14.9 1.7e+02 2.0 0.1 8.4 10 0 0 10 10 10 0 PPR repeat ParD_like PF11903.8 KOO27274.1 - 0.00092 19.2 0.6 0.0028 17.7 0.6 1.8 1 0 0 1 1 1 1 ParD-like antitoxin of type II bacterial toxin-antitoxin system Med11 PF10280.9 KOO27274.1 - 0.03 14.8 4.8 0.41 11.1 1.5 2.5 2 0 0 2 2 2 0 Mediator complex protein KMP11 PF03037.16 KOO27274.1 - 0.042 14.6 0.1 0.042 14.6 0.1 2.4 2 1 1 3 3 3 0 Kinetoplastid membrane protein 11 Phage_GP20 PF06810.11 KOO27274.1 - 0.054 13.3 15.7 0.065 13.0 1.3 4.1 3 1 1 4 4 4 0 Phage minor structural protein GP20 CDK5_activator PF03261.15 KOO27274.1 - 0.24 10.9 2.6 0.42 10.1 2.6 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DinB_2 PF12867.7 KOO27274.1 - 0.26 11.8 4.1 1.9 9.0 0.5 3.0 2 1 0 2 2 2 0 DinB superfamily TSC22 PF01166.18 KOO27274.1 - 0.38 11.1 10.2 0.41 11.0 0.4 3.8 4 0 0 4 4 4 0 TSC-22/dip/bun family PKcGMP_CC PF16808.5 KOO27274.1 - 0.57 10.1 7.6 8.9 6.3 0.0 4.2 4 1 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Pox_A_type_inc PF04508.12 KOO27274.1 - 0.7 9.8 4.7 1.7 8.6 0.9 3.2 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat MbeD_MobD PF04899.12 KOO27274.1 - 1.1 9.4 16.3 2.6 8.2 0.2 4.2 4 0 0 4 4 4 0 MbeD/MobD like ATG16 PF08614.11 KOO27274.1 - 2.6 8.2 0.0 2.6 8.2 0.0 4.3 3 1 0 4 4 4 0 Autophagy protein 16 (ATG16) DUF2894 PF11445.8 KOO27274.1 - 4.3 7.8 20.5 0.42 11.1 0.5 2.4 3 0 0 3 3 2 0 Protein of unknown function (DUF2894) Sec8_exocyst PF04048.14 KOO27274.1 - 5.2 6.9 11.3 9.4 6.1 0.1 3.4 3 1 1 4 4 4 0 Sec8 exocyst complex component specific domain Occludin_ELL PF07303.13 KOO27274.1 - 5.8 7.7 0.0 5.8 7.7 0.0 3.9 3 2 0 3 3 3 0 Occludin homology domain FAM76 PF16046.5 KOO27274.1 - 6.8 5.9 20.9 0.58 9.5 13.3 2.8 2 1 1 3 3 3 0 FAM76 protein DUF3450 PF11932.8 KOO27274.1 - 7.8 5.7 27.6 0.84 8.9 8.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3450) EF-hand_7 PF13499.6 KOO27275.1 - 6.1e-13 49.0 1.7 2e-08 34.5 0.3 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO27275.1 - 1.2e-12 47.5 0.6 5.9e-09 35.7 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO27275.1 - 3.3e-12 45.3 0.2 0.00011 21.8 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO27275.1 - 6e-12 44.2 0.7 1.6e-05 24.1 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO27275.1 - 0.00028 20.2 9.4 0.00078 18.8 0.1 3.0 3 0 0 3 3 3 2 EF hand DUF1708 PF08101.11 KOO27275.1 - 0.4 9.8 4.0 0.59 9.2 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) EF-hand_7 PF13499.6 KOO27276.1 - 1.1e-07 32.2 0.2 1.3e-06 28.8 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO27276.1 - 2.4e-07 29.8 1.5 9.4e-07 28.0 0.0 2.6 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 KOO27276.1 - 2.7e-07 30.0 1.7 7.1e-07 28.7 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 KOO27276.1 - 4.2e-06 26.0 0.1 2e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO27276.1 - 0.0031 17.3 0.0 0.27 11.1 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO27276.1 - 0.051 13.9 0.0 2.1 8.7 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain Acyl-CoA_dh_N PF02771.16 KOO27276.1 - 0.12 13.1 0.2 1.2 9.8 0.1 2.3 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain Exostosin PF03016.15 KOO27277.1 - 6.6e-39 133.9 0.4 6.6e-39 133.9 0.4 2.3 2 1 0 2 2 2 1 Exostosin family EGF_2 PF07974.13 KOO27277.1 - 1e-10 41.8 44.3 0.0002 21.6 7.5 4.6 4 0 0 4 4 4 3 EGF-like domain Laminin_EGF PF00053.24 KOO27277.1 - 0.0053 16.9 32.1 0.01 16.0 6.2 3.6 2 1 1 3 3 3 2 Laminin EGF domain EGF PF00008.27 KOO27277.1 - 5.8 7.3 34.6 0.38 11.1 7.7 4.1 4 0 0 4 4 4 0 EGF-like domain Helicase_C PF00271.31 KOO27278.1 - 4.9e-27 94.5 0.0 4.3e-26 91.4 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO27278.1 - 3.3e-19 69.3 0.0 7.9e-19 68.1 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 KOO27278.1 - 0.0011 18.3 0.0 0.0017 17.6 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Myosin_head PF00063.21 KOO27279.1 - 2e-78 264.3 0.0 4.9e-41 140.7 0.0 4.1 2 1 2 4 4 4 4 Myosin head (motor domain) AAA_16 PF13191.6 KOO27279.1 - 0.2 12.1 2.2 0.35 11.2 0.1 2.5 2 1 0 2 2 2 0 AAA ATPase domain GABP-alpha PF11620.8 KOO27280.1 - 4e-06 26.9 0.6 0.3 11.3 0.1 3.6 3 0 0 3 3 3 3 GA-binding protein alpha chain UvrC_HhH_N PF08459.11 KOO27280.1 - 0.016 15.1 3.0 0.029 14.3 1.0 2.4 1 1 1 2 2 2 0 UvrC Helix-hairpin-helix N-terminal Pkinase PF00069.25 KOO27282.1 - 4.6e-56 190.1 0.0 5.7e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27282.1 - 1.4e-34 119.6 0.0 1.9e-34 119.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO27282.1 - 9.9e-08 31.3 0.0 1.7e-07 30.5 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KOO27282.1 - 9e-07 28.5 0.0 1.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO27282.1 - 0.00076 19.5 1.0 0.074 13.0 0.4 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 KOO27282.1 - 0.012 15.2 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 KOO27282.1 - 0.025 13.3 0.0 0.067 11.9 0.0 1.6 1 1 1 2 2 2 0 Fungal protein kinase Kdo PF06293.14 KOO27282.1 - 0.032 13.6 0.2 0.049 13.0 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_127 PF07944.12 KOO27283.1 - 0.046 12.2 0.0 0.051 12.1 0.0 1.1 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 Ribosomal_S11 PF00411.19 KOO27285.1 - 6.1e-45 152.1 0.7 8e-45 151.8 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Ion_trans PF00520.31 KOO27286.1 - 2.6e-93 311.8 14.8 3.9e-53 180.2 1.7 3.1 3 0 0 3 3 3 3 Ion transport protein GPHH PF16905.5 KOO27286.1 - 9.7e-07 28.5 0.0 2e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO27286.1 - 0.0015 17.3 1.0 0.0015 17.3 1.0 5.5 5 1 1 6 6 6 2 Polycystin cation channel HrpB4 PF09502.10 KOO27286.1 - 0.026 14.4 3.9 0.2 11.5 0.2 2.4 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB4) Adeno_E3_14_5 PF04834.12 KOO27286.1 - 0.11 13.0 0.1 2.8 8.5 0.0 2.6 2 0 0 2 2 2 0 Early E3 14.5 kDa protein Ion_trans PF00520.31 KOO27287.1 - 1.2e-91 306.3 3.8 5.5e-61 205.9 0.0 2.0 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 KOO27287.1 - 0.00019 20.3 26.1 0.33 9.6 2.4 4.7 3 2 2 5 5 5 4 Polycystin cation channel UPF0542 PF15086.6 KOO27287.1 - 0.032 14.2 0.0 0.091 12.7 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 Lustrin_cystein PF14625.6 KOO27287.1 - 0.12 12.8 0.8 0.24 11.8 0.8 1.4 1 0 0 1 1 1 0 Lustrin, cysteine-rich repeated domain RRM_1 PF00076.22 KOO27288.1 - 4.9e-50 167.2 0.0 4.4e-16 58.5 0.0 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOO27288.1 - 4.8e-07 29.8 0.1 0.11 12.6 0.0 3.7 3 1 0 3 3 3 2 RNA recognition motif Cas_Cas2CT1978 PF09707.10 KOO27288.1 - 0.084 13.0 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas2CT1978) Trefoil PF00088.18 KOO27289.1 - 4.1e-12 45.8 2.1 9.2e-12 44.7 2.1 1.6 1 0 0 1 1 1 1 Trefoil (P-type) domain 2OG-FeII_Oxy_3 PF13640.6 KOO27289.1 - 1.2e-07 32.5 0.0 3.3e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO27289.1 - 0.034 14.6 0.0 0.084 13.4 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Chromo PF00385.24 KOO27290.1 - 2.4e-10 40.1 0.1 2.4e-10 40.1 0.1 1.8 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Acetyltransf_10 PF13673.7 KOO27290.1 - 0.0054 16.7 0.1 0.012 15.6 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOO27290.1 - 0.11 13.0 0.2 1.3 9.5 0.1 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain TLC PF03219.14 KOO27291.1 - 1e-05 24.5 12.3 8.7e-05 21.4 3.1 2.3 2 0 0 2 2 2 2 TLC ATP/ADP transporter Asp_Arg_Hydrox PF05118.15 KOO27292.1 - 1.6e-41 141.7 0.0 2.5e-41 141.1 0.0 1.3 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Hydrolase_4 PF12146.8 KOO27292.1 - 0.01 15.1 0.0 0.024 13.9 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 UPF0227 PF05728.12 KOO27292.1 - 0.04 13.8 0.0 0.088 12.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) DUF996 PF06195.13 KOO27293.1 - 0.0087 16.3 0.1 0.018 15.4 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF996) DUF2273 PF10031.9 KOO27293.1 - 1.1 9.3 6.1 2.4 8.2 6.1 1.5 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) HSP70 PF00012.20 KOO27294.1 - 4.9e-68 229.8 0.1 3.1e-53 180.9 0.1 2.1 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 KOO27294.1 - 4.1e-05 22.6 1.0 0.00045 19.1 1.0 2.4 1 1 0 1 1 1 1 MreB/Mbl protein Ion_trans_2 PF07885.16 KOO27295.1 - 0.067 13.2 3.3 0.13 12.3 3.3 1.4 1 1 0 1 1 1 0 Ion channel Vint PF14623.6 KOO27297.1 - 1.6e-07 31.3 0.0 4.5e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Hint-domain Hint PF01079.20 KOO27297.1 - 0.065 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Hint module SF3b1 PF08920.10 KOO27298.1 - 5.3e-37 126.9 4.5 8.4e-37 126.3 3.5 1.9 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT PF02985.22 KOO27298.1 - 5e-11 41.9 7.9 0.2 12.0 0.1 9.2 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 KOO27298.1 - 3.5e-10 40.1 8.2 0.15 12.5 0.0 8.0 6 2 2 8 8 8 2 HEAT repeats HEAT_EZ PF13513.6 KOO27298.1 - 1.8e-06 28.3 7.0 1.4 9.5 0.0 7.3 7 1 0 7 7 7 2 HEAT-like repeat Cnd1 PF12717.7 KOO27298.1 - 1.1e-05 25.5 9.0 4.5 7.3 0.0 6.7 6 3 2 8 8 8 4 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KOO27298.1 - 2.9e-05 22.9 1.1 0.0085 14.7 0.0 3.0 1 1 0 3 3 3 2 Adaptin N terminal region IFRD PF05004.13 KOO27298.1 - 0.00014 21.0 0.0 1.7 7.7 0.0 3.4 3 0 0 3 3 3 2 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.7 KOO27298.1 - 0.00019 22.0 0.2 0.52 10.9 0.0 4.9 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region Dopey_N PF04118.14 KOO27298.1 - 0.0041 16.3 0.8 0.97 8.5 0.0 3.6 4 1 0 4 4 4 1 Dopey, N-terminal TIP120 PF08623.10 KOO27298.1 - 0.014 15.2 0.4 1.9 8.2 0.0 2.8 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) DUF3385 PF11865.8 KOO27298.1 - 0.022 14.7 0.7 13 5.7 0.0 5.1 5 2 0 5 5 5 0 Domain of unknown function (DUF3385) NUC173 PF08161.12 KOO27298.1 - 0.047 13.4 0.2 4.4 6.9 0.0 4.0 2 2 2 4 4 4 0 NUC173 domain AAA_13 PF13166.6 KOO27299.1 - 0.054 12.1 2.5 0.083 11.5 2.5 1.3 1 0 0 1 1 1 0 AAA domain EMP24_GP25L PF01105.24 KOO27299.1 - 0.055 13.4 0.4 0.15 12.0 0.0 1.7 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD Vps54_N PF10475.9 KOO27299.1 - 0.06 12.6 1.6 0.095 12.0 1.6 1.2 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex JAKMIP_CC3 PF16034.5 KOO27299.1 - 0.34 10.8 8.6 0.64 9.9 8.6 1.4 1 0 0 1 1 1 0 JAKMIP CC3 domain Atg14 PF10186.9 KOO27299.1 - 0.75 8.8 4.0 1.4 7.9 4.0 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5344 PF17279.2 KOO27299.1 - 3.2 8.4 8.6 12 6.6 1.9 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF5344) Herpes_UL25 PF01499.16 KOO27299.1 - 3.3 6.1 7.9 5.5 5.4 7.7 1.4 1 1 0 1 1 1 0 Herpesvirus UL25 family CN_hydrolase PF00795.22 KOO27300.1 - 2.5e-50 171.3 0.0 4e-50 170.6 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DEAD PF00270.29 KOO27300.1 - 8e-42 143.0 0.0 1.3e-41 142.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO27300.1 - 8.1e-28 97.0 0.0 1.9e-27 95.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOO27300.1 - 0.023 15.0 0.0 0.52 10.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain BTB_2 PF02214.22 KOO27301.1 - 3.8e-17 62.4 0.0 5.8e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 KOO27301.1 - 0.026 14.7 0.0 0.038 14.2 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain EF-hand_1 PF00036.32 KOO27302.1 - 3.2e-12 45.0 0.6 4.7e-06 25.8 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO27302.1 - 7.3e-11 41.1 1.0 0.0001 22.0 0.4 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO27302.1 - 1.3e-10 40.3 1.1 2.1e-05 23.8 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO27302.1 - 5e-06 26.9 7.3 2.3e-05 24.8 6.8 2.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO27302.1 - 0.0013 18.5 0.2 0.06 13.2 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair LRR_6 PF13516.6 KOO27303.1 - 3.3e-47 154.5 9.6 3.2e-05 23.6 0.1 8.2 8 0 0 8 8 8 8 Leucine Rich repeat LRR_4 PF12799.7 KOO27303.1 - 1e-10 41.6 2.5 3.4 8.2 0.0 6.8 4 2 0 6 6 6 1 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.12 KOO27303.1 - 1.3e-06 28.5 7.4 0.057 13.7 0.1 4.9 3 2 2 5 5 5 3 RNA 2'-O ribose methyltransferase substrate binding LRR_1 PF00560.33 KOO27303.1 - 9.7e-06 25.5 0.0 1e+02 4.1 0.0 6.7 8 0 0 8 8 7 0 Leucine Rich Repeat CbiG_N PF11760.8 KOO27303.1 - 2.1e-05 24.5 22.0 0.61 10.1 0.3 6.9 6 1 1 7 7 7 3 Cobalamin synthesis G N-terminal RHH_7 PF16777.5 KOO27303.1 - 5.4e-05 23.5 0.1 17 5.9 0.0 4.6 1 1 3 4 4 4 0 Transcriptional regulator, RHH-like, CopG HOASN PF14515.6 KOO27303.1 - 0.0018 18.6 19.5 27 5.2 0.1 7.1 1 1 7 8 8 8 0 Haem-oxygenase-associated N-terminal helices LRR_8 PF13855.6 KOO27303.1 - 0.0047 16.7 9.0 28 4.6 1.5 6.1 3 2 2 5 5 5 0 Leucine rich repeat CoatB PF10389.9 KOO27303.1 - 0.0076 16.1 10.4 2.3 8.1 0.8 5.3 5 1 1 6 6 6 1 Bacteriophage coat protein B YycC PF14174.6 KOO27303.1 - 0.016 15.0 0.0 25 4.8 0.0 4.9 7 0 0 7 7 7 0 YycC-like protein DUF3107 PF11305.8 KOO27303.1 - 0.02 15.1 6.2 9 6.6 0.0 4.9 2 1 3 6 6 6 0 Protein of unknown function (DUF3107) CTV_P13 PF06922.11 KOO27303.1 - 0.062 13.4 0.5 36 4.5 0.0 3.8 2 1 2 4 4 4 0 Citrus tristeza virus P13 protein DUF4092 PF13322.6 KOO27303.1 - 0.081 12.8 0.1 2.1 8.2 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4092) UPF0029 PF01205.19 KOO27303.1 - 0.082 13.2 0.4 7.8 6.9 0.0 3.1 3 1 1 4 4 4 0 Uncharacterized protein family UPF0029 FAM25 PF15825.5 KOO27303.1 - 0.8 10.1 33.7 3 8.2 0.9 7.7 5 3 3 8 8 8 0 FAM25 family DUF2202 PF09968.9 KOO27303.1 - 1.7 8.5 7.5 63 3.4 0.1 5.1 1 1 3 5 5 5 0 Uncharacterized protein domain (DUF2202) EF-hand_1 PF00036.32 KOO27305.1 - 6.3e-27 91.1 3.1 1.8e-05 23.9 0.2 5.4 5 0 0 5 5 5 5 EF hand EF-hand_5 PF13202.6 KOO27305.1 - 1.5e-22 78.0 5.1 0.00062 19.1 0.2 5.5 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 KOO27305.1 - 7.2e-21 74.4 2.4 2.9e-08 34.1 0.5 3.9 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO27305.1 - 9.1e-21 72.0 0.1 0.0082 16.0 0.0 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_8 PF13833.6 KOO27305.1 - 1.9e-15 56.4 6.1 7.7e-07 28.9 1.8 5.1 4 1 1 5 5 5 4 EF-hand domain pair Dockerin_1 PF00404.18 KOO27305.1 - 3.4e-06 27.2 6.3 0.15 12.3 1.2 3.9 2 1 2 4 4 4 4 Dockerin type I domain EF-hand_4 PF12763.7 KOO27305.1 - 0.0046 16.9 1.1 0.066 13.2 0.6 3.0 2 2 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand PDZ_6 PF17820.1 KOO27305.1 - 0.014 15.3 0.0 0.089 12.7 0.0 2.5 1 0 0 1 1 1 0 PDZ domain SPARC_Ca_bdg PF10591.9 KOO27305.1 - 0.19 12.1 0.0 2.9 8.3 0.0 3.0 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region P66_CC PF16563.5 KOO27305.1 - 5.5 6.7 8.8 8.6 6.1 1.4 3.0 2 0 0 2 2 2 0 Coiled-coil and interaction region of P66A and P66B with MBD2 Glycos_transf_1 PF00534.20 KOO27308.1 - 1e-27 96.7 0.0 1.8e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOO27308.1 - 1.4e-25 90.3 1.6 3.7e-25 88.9 0.5 2.2 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOO27308.1 - 6.4e-23 81.6 7.6 6.4e-23 81.6 7.6 2.3 2 2 1 3 3 3 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 KOO27308.1 - 1.6e-16 61.1 21.3 1.8e-16 61.0 13.4 2.7 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 KOO27308.1 - 6.2e-09 36.1 0.1 2.4e-08 34.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 KOO27308.1 - 0.00081 19.4 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like baeRF_family2 PF18844.1 KOO27308.1 - 0.016 15.3 3.6 3.4 7.7 0.1 3.4 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 2 YAcAr PF10686.9 KOO27308.1 - 0.064 13.2 0.1 0.21 11.5 0.1 1.9 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family VWA_CoxE PF05762.14 KOO27308.1 - 0.078 12.4 0.6 7.8 5.8 0.0 2.4 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein RelA_SpoT PF04607.17 KOO27310.1 - 3.6e-21 75.6 0.0 8.8e-21 74.4 0.0 1.7 1 1 0 1 1 1 1 Region found in RelA / SpoT proteins HD_4 PF13328.6 KOO27310.1 - 1.8e-11 44.0 0.8 4.2e-11 42.8 0.2 1.9 3 0 0 3 3 3 1 HD domain Helicase_C PF00271.31 KOO27311.1 - 1.9e-13 50.7 0.0 3.5e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RQC PF09382.10 KOO27311.1 - 3.6e-07 30.0 0.0 1.4e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 RQC domain RecQ_Zn_bind PF16124.5 KOO27311.1 - 5.6e-07 30.2 2.5 1.1e-06 29.3 2.5 1.5 1 0 0 1 1 1 1 RecQ zinc-binding DUF4913 PF16259.5 KOO27312.1 - 0.015 15.3 0.1 0.03 14.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) CPV_Polyhedrin PF17515.2 KOO27312.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Cypovirus polyhedrin TAF8_C PF10406.9 KOO27313.1 - 0.25 11.9 0.0 0.25 11.9 0.0 2.5 3 0 0 3 3 3 0 Transcription factor TFIID complex subunit 8 C-term WLM PF08325.10 KOO27314.1 - 7.2e-19 68.6 0.0 3e-18 66.6 0.0 2.0 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.17 KOO27314.1 - 8.8e-08 32.4 1.2 1.7e-07 31.5 1.2 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 zf-RanBP PF00641.18 KOO27314.1 - 0.0013 18.0 14.2 0.13 11.6 2.1 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others NAAA-beta PF15508.6 KOO27314.1 - 0.02 15.2 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Hist_deacetyl PF00850.19 KOO27315.1 - 3.3e-84 283.0 0.3 4.7e-84 282.5 0.1 1.3 2 0 0 2 2 2 1 Histone deacetylase domain LpoB PF13036.6 KOO27315.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Peptidoglycan-synthase activator LpoB N2227 PF07942.12 KOO27316.1 - 2e-76 256.8 0.0 3.1e-76 256.2 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein CALCOCO1 PF07888.11 KOO27316.1 - 0.066 12.1 0.2 0.096 11.5 0.2 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like TTL PF03133.15 KOO27317.1 - 1.4e-42 145.8 0.0 2.9e-42 144.8 0.0 1.4 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO27317.1 - 2.1e-05 23.9 0.0 0.023 13.9 0.0 2.6 2 1 0 2 2 2 2 YheC/D like ATP-grasp Rx_N PF18052.1 KOO27317.1 - 0.058 13.7 0.0 0.44 10.9 0.0 2.1 2 0 0 2 2 2 0 Rx N-terminal domain ATP-grasp_3 PF02655.14 KOO27317.1 - 0.19 11.7 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain Prp18 PF02840.15 KOO27318.1 - 1.4e-53 180.7 0.2 1.4e-53 180.7 0.2 1.5 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 KOO27318.1 - 4.1e-12 45.4 0.8 4.1e-12 45.4 0.8 2.1 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like Phage_int_SAM_4 PF13495.6 KOO27318.1 - 0.092 13.2 0.1 1.2 9.7 0.0 2.5 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Ank_4 PF13637.6 KOO27320.1 - 1.2e-15 57.6 1.0 0.00024 21.6 0.1 4.1 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO27320.1 - 2.5e-12 46.7 0.9 8.4e-05 22.8 0.1 4.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_2 PF12796.7 KOO27320.1 - 3.5e-11 43.5 1.2 8.3e-07 29.5 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO27320.1 - 5.4e-05 23.4 0.0 0.0038 17.5 0.0 3.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27320.1 - 0.0056 17.1 2.2 8.6 7.3 0.3 4.9 6 1 0 6 6 6 1 Ankyrin repeat Cys_Met_Meta_PP PF01053.20 KOO27321.1 - 3e-114 381.5 0.0 4.4e-114 381.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOO27321.1 - 0.00035 19.9 0.0 0.00051 19.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KOO27321.1 - 0.2 10.5 0.0 0.31 9.9 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Ank_2 PF12796.7 KOO27322.1 - 2.5e-36 124.1 3.1 1.6e-15 57.5 0.6 4.1 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO27322.1 - 4.6e-28 94.2 3.2 0.00044 20.5 0.1 6.3 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 KOO27322.1 - 2.5e-24 84.6 8.5 2.6e-05 24.5 0.1 6.3 5 1 1 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 KOO27322.1 - 1.6e-23 82.4 3.0 9.4e-07 29.0 0.1 5.4 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO27322.1 - 3e-22 78.7 4.2 3.3e-09 37.1 0.2 5.1 2 1 3 5 5 5 4 Ankyrin repeats (many copies) YCII PF03795.14 KOO27323.1 - 4.4e-08 33.4 0.0 4.5e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 YCII-related domain ubiquitin PF00240.23 KOO27323.1 - 0.0025 17.5 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOO27323.1 - 0.028 14.2 0.0 0.039 13.8 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like TUG-UBL1 PF11470.8 KOO27323.1 - 0.17 12.1 0.0 0.38 11.0 0.0 1.5 1 0 0 1 1 1 0 TUG ubiquitin-like domain zf-CHCC PF10276.9 KOO27324.1 - 0.013 15.5 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Zinc-finger domain ASH PF15780.5 KOO27325.1 - 1.8e-37 127.5 12.4 1.8e-05 24.9 0.0 16.0 16 0 0 16 16 16 9 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 KOO27325.1 - 1.8e-14 53.6 3.1 0.32 11.1 0.2 10.6 11 2 0 11 11 11 4 Protein of unknown function (DUF1573) Motile_Sperm PF00635.26 KOO27325.1 - 2.6e-13 49.8 0.0 0.53 10.2 0.0 7.8 7 1 1 8 8 8 3 MSP (Major sperm protein) domain MYCBPAP PF14646.6 KOO27325.1 - 4.6e-12 45.6 0.1 7.7e-06 25.1 0.0 4.1 4 1 0 5 5 5 2 MYCBP-associated protein family TMEM131_like PF12371.8 KOO27325.1 - 5.3e-10 39.4 6.6 0.011 16.0 0.0 9.0 9 0 0 9 9 9 1 Transmembrane protein 131-like PapD-like PF14874.6 KOO27325.1 - 1.8e-09 37.7 0.0 0.56 10.4 0.0 7.8 9 0 0 9 9 9 3 Flagellar-associated PapD-like DUF4232 PF14016.6 KOO27325.1 - 0.0025 18.0 9.2 0.14 12.2 0.3 5.2 5 1 0 5 5 5 2 Protein of unknown function (DUF4232) DUF2484 PF10658.9 KOO27326.1 - 0.4 11.0 3.7 0.41 11.0 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2484) Lyase_1 PF00206.20 KOO27328.1 - 5.3e-93 311.8 0.0 7.1e-93 311.4 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 KOO27328.1 - 2.6e-12 47.3 0.0 7.4e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal DEK_C PF08766.11 KOO27328.1 - 0.0025 17.7 0.0 0.0057 16.6 0.0 1.6 1 0 0 1 1 1 1 DEK C terminal domain Ser_hydrolase PF06821.13 KOO27328.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Methyltransf_24 PF13578.6 KOO27329.1 - 8.9e-09 36.3 0.0 4.7e-05 24.3 0.0 2.7 2 1 0 2 2 2 2 Methyltransferase domain CmcI PF04989.12 KOO27329.1 - 0.069 12.8 0.0 0.24 11.1 0.0 1.8 2 0 0 2 2 2 0 Cephalosporin hydroxylase Ribosomal_L19 PF01245.20 KOO27330.1 - 1.3e-08 34.8 0.0 2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 Pantoate_ligase PF02569.15 KOO27330.1 - 0.12 11.5 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase BRE1 PF08647.11 KOO27331.1 - 9.9e-10 38.4 2.0 9.9e-10 38.4 2.0 9.3 4 2 7 11 11 11 1 BRE1 E3 ubiquitin ligase Lig_chan-Glu_bd PF10613.9 KOO27331.1 - 0.19 12.0 1.6 0.91 9.7 0.1 2.5 2 1 1 3 3 3 0 Ligated ion channel L-glutamate- and glycine-binding site DUF4378 PF14309.6 KOO27333.1 - 0.064 13.6 0.1 0.2 12.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4378) GAF PF01590.26 KOO27334.1 - 6e-37 127.2 1.3 5.2e-18 66.0 0.0 5.6 5 0 0 5 5 5 5 GAF domain GAF_2 PF13185.6 KOO27334.1 - 7.5e-24 84.6 4.8 4.4e-09 36.8 0.0 5.5 6 0 0 6 6 6 4 GAF domain GAF_3 PF13492.6 KOO27334.1 - 2.3e-15 57.1 4.5 4e-09 36.9 0.0 6.5 6 1 0 6 6 6 2 GAF domain DUF3369 PF11849.8 KOO27334.1 - 0.0025 18.0 0.1 0.013 15.7 0.1 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3369) IQ PF00612.27 KOO27334.1 - 0.068 13.0 1.8 0.18 11.7 1.8 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif SpoVT_C PF15714.5 KOO27334.1 - 0.13 12.3 0.0 3.4 7.7 0.0 3.2 3 0 0 3 3 3 0 Stage V sporulation protein T C-terminal, transcription factor Arm PF00514.23 KOO27335.1 - 2e-34 116.5 60.2 0.00034 20.6 0.1 18.2 19 0 0 19 19 19 12 Armadillo/beta-catenin-like repeat DUF5578 PF17741.1 KOO27335.1 - 0.0031 17.0 8.9 0.027 13.9 0.0 4.3 5 0 0 5 5 5 2 Family of unknown function (DUF5578) V-ATPase_H_N PF03224.14 KOO27335.1 - 0.0082 15.5 0.2 20 4.3 0.0 4.4 4 1 0 4 4 4 1 V-ATPase subunit H DUF3361 PF11841.8 KOO27335.1 - 0.011 15.7 2.9 13 5.8 0.1 4.6 5 1 0 5 5 5 0 Domain of unknown function (DUF3361) Arm_2 PF04826.13 KOO27335.1 - 0.027 14.0 0.1 1.3 8.4 0.0 3.4 4 1 0 4 4 4 0 Armadillo-like EF-hand_6 PF13405.6 KOO27336.1 - 1.1e-13 49.8 0.7 0.0022 17.8 0.2 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO27336.1 - 2.1e-13 48.8 2.4 0.0013 18.2 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 KOO27336.1 - 4.3e-08 32.3 4.4 0.0016 17.9 0.1 3.6 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KOO27336.1 - 7.7e-08 32.7 4.0 4.3e-05 23.9 1.3 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO27336.1 - 2e-05 24.3 0.1 0.028 14.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair TMF_TATA_bd PF12325.8 KOO27336.1 - 0.35 11.1 4.7 0.67 10.2 4.7 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Glutaredoxin PF00462.24 KOO27337.1 - 0.011 15.9 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin Rib_recp_KP_reg PF05104.12 KOO27338.1 - 0.0031 18.6 17.6 0.0031 18.6 17.6 2.6 2 1 0 2 2 2 1 Ribosome receptor lysine/proline rich region Zip PF02535.22 KOO27338.1 - 0.057 12.6 0.8 0.063 12.5 0.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SAPS PF04499.15 KOO27338.1 - 0.13 11.0 5.9 0.17 10.6 5.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 KOO27338.1 - 0.5 10.4 1.8 0.83 9.7 1.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MCM_bind PF09739.9 KOO27338.1 - 0.95 7.8 4.4 1.3 7.4 4.4 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SelP_N PF04592.14 KOO27338.1 - 6.2 6.1 13.8 12 5.3 13.8 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 KOO27338.1 - 7.2 5.3 7.7 10 4.8 7.7 1.2 1 0 0 1 1 1 0 Presenilin PhyH PF05721.13 KOO27340.1 - 6.3e-14 52.7 0.0 9e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Consortin_C PF15281.6 KOO27341.1 - 0.21 11.6 1.8 0.29 11.1 1.8 1.2 1 0 0 1 1 1 0 Consortin C-terminus PRA1 PF03208.19 KOO27341.1 - 0.96 9.1 5.4 1.2 8.7 5.4 1.1 1 0 0 1 1 1 0 PRA1 family protein Promethin PF16015.5 KOO27341.1 - 0.96 9.4 10.3 1.3 8.9 10.3 1.1 1 0 0 1 1 1 0 Promethin Anophelin PF10731.9 KOO27341.1 - 4.4 7.2 6.6 12 5.8 0.5 3.0 2 1 1 3 3 3 0 Thrombin inhibitor from mosquito LRR_4 PF12799.7 KOO27344.1 - 1.1e-17 63.8 10.6 0.00011 22.5 0.6 5.3 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO27344.1 - 2.3e-10 40.2 0.1 0.0012 18.4 0.1 3.6 3 1 0 3 3 3 3 Leucine-rich repeat LRR_8 PF13855.6 KOO27344.1 - 6.2e-10 38.7 16.9 0.0004 20.1 0.3 4.4 4 1 0 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 KOO27344.1 - 0.00081 19.3 8.7 0.43 10.8 0.1 5.3 6 0 0 6 6 6 2 Leucine Rich repeat EF-hand_5 PF13202.6 KOO27344.1 - 0.0012 18.3 0.0 0.0027 17.1 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO27344.1 - 0.0045 16.5 0.0 0.0091 15.5 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO27344.1 - 0.0091 15.9 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO27344.1 - 0.14 12.6 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair LRR_1 PF00560.33 KOO27344.1 - 1 10.1 9.2 3.5e+02 2.5 0.0 6.0 5 2 0 5 5 5 0 Leucine Rich Repeat SOGA PF11365.8 KOO27345.1 - 8.1e-05 23.7 5.2 8.1e-05 23.7 5.2 1.8 2 0 0 2 2 2 1 Protein SOGA TSNAXIP1_N PF15739.5 KOO27345.1 - 0.00021 21.6 1.3 0.0014 19.0 1.3 2.2 1 1 0 1 1 1 1 Translin-associated factor X-interacting N-terminus KASH_CCD PF14662.6 KOO27345.1 - 0.0089 15.9 4.3 0.0089 15.9 4.3 1.7 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH TMPIT PF07851.13 KOO27345.1 - 0.081 12.2 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF632 PF04782.12 KOO27345.1 - 0.088 12.1 0.5 0.13 11.6 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF632) Fez1 PF06818.15 KOO27345.1 - 0.12 12.9 8.0 0.18 12.2 8.0 1.2 1 0 0 1 1 1 0 Fez1 HAUS6_N PF14661.6 KOO27345.1 - 0.15 11.6 2.1 0.22 11.1 2.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus TMCO5 PF14992.6 KOO27345.1 - 0.29 10.7 2.8 0.41 10.2 2.8 1.2 1 0 0 1 1 1 0 TMCO5 family Rootletin PF15035.6 KOO27345.1 - 0.29 11.1 11.3 0.49 10.4 11.0 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Herpes_UL25 PF01499.16 KOO27345.1 - 1.1 7.8 4.2 1.6 7.2 4.2 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family TMF_DNA_bd PF12329.8 KOO27345.1 - 2 8.5 8.0 6.1 6.9 8.0 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding APG6_N PF17675.1 KOO27345.1 - 3 8.4 15.6 0.71 10.4 10.2 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region RPN7 PF10602.9 KOO27346.1 - 9.4e-45 152.4 1.3 1.3e-44 151.9 1.3 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 KOO27346.1 - 8.3e-09 35.9 0.0 1.6e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 PCI domain Abhydrolase_3 PF07859.13 KOO27347.1 - 2e-06 27.8 2.8 1.2e-05 25.3 2.8 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO27347.1 - 0.0025 17.1 0.3 0.22 10.8 0.1 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOO27347.1 - 0.012 15.2 0.4 3.7 7.0 0.0 2.7 3 0 0 3 3 3 0 Prolyl oligopeptidase family DUF2685 PF10886.8 KOO27349.1 - 8.7 6.6 8.0 3.8e+03 -1.8 8.0 3.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2685) TPR_1 PF00515.28 KOO27350.1 - 2.5e-11 42.9 8.3 0.0027 17.4 0.5 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO27350.1 - 7.7e-07 29.2 7.3 2e-05 24.6 4.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27350.1 - 1.3e-05 24.9 23.1 0.0026 17.8 1.9 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO27350.1 - 3.5e-05 24.0 7.4 0.73 10.2 0.6 3.7 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27350.1 - 0.0074 16.9 0.8 0.0074 16.9 0.8 4.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO27350.1 - 1.1 9.5 6.2 2.7 8.2 1.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat LicD PF04991.13 KOO27350.1 - 1.1 9.3 5.5 2.2 8.4 5.5 1.4 1 0 0 1 1 1 0 LicD family V_ATPase_I PF01496.19 KOO27350.1 - 2.8 5.7 7.5 14 3.4 0.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family F-box-like PF12937.7 KOO27351.1 - 0.12 12.3 0.0 0.36 10.8 0.0 1.9 1 0 0 1 1 1 0 F-box-like MJ1316 PF04457.12 KOO27352.1 - 3.9e-16 59.5 0.0 6.5e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Cupin_4 PF08007.12 KOO27353.1 - 2.6e-13 50.2 0.1 1.5e-12 47.7 0.1 1.9 1 1 0 1 1 1 1 Cupin superfamily protein HEAT_EZ PF13513.6 KOO27354.1 - 0.016 15.7 1.4 0.068 13.7 1.4 2.2 1 0 0 1 1 1 0 HEAT-like repeat Arm PF00514.23 KOO27354.1 - 0.45 10.6 2.6 14 5.9 0.2 3.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat TIG PF01833.24 KOO27355.1 - 2.7e-30 104.3 1.1 2.6e-05 24.2 0.0 7.7 8 1 0 8 8 8 5 IPT/TIG domain Kringle PF00051.18 KOO27355.1 - 4.3e-19 68.6 0.6 9.7e-19 67.5 0.6 1.6 1 0 0 1 1 1 1 Kringle domain TIG_plexin PF17960.1 KOO27355.1 - 8.9e-08 32.0 0.0 1.5 8.9 0.0 5.2 5 0 0 5 5 5 3 TIG domain Glyco_hydro2_C5 PF18565.1 KOO27357.1 - 0.082 12.7 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 Response_reg PF00072.24 KOO27358.1 - 0.00013 22.1 0.0 0.00021 21.4 0.0 1.5 1 1 0 1 1 1 1 Response regulator receiver domain DUF4803 PF16061.5 KOO27358.1 - 0.085 12.3 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4803) ABC_tran PF00005.27 KOO27359.1 - 5.2e-52 176.0 0.0 5.7e-30 104.6 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO27359.1 - 1.3e-22 81.0 0.9 7.5e-07 29.2 0.0 4.5 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 KOO27359.1 - 6e-19 68.3 51.4 2.1e-15 56.7 17.9 2.7 3 0 0 3 3 3 2 ABC-2 family transporter protein SMC_N PF02463.19 KOO27359.1 - 2.1e-06 27.3 0.2 0.23 10.9 0.0 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOO27359.1 - 0.0002 21.9 1.5 0.28 11.7 0.1 2.2 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 KOO27359.1 - 0.00092 19.4 0.1 0.55 10.5 0.0 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 KOO27359.1 - 0.0015 18.2 5.0 0.037 13.8 0.5 2.9 3 0 0 3 3 3 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO27359.1 - 0.0025 17.7 0.0 1.3 8.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 KOO27359.1 - 0.021 14.5 3.2 3 7.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain PX PF00787.24 KOO27359.1 - 0.023 14.7 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 PX domain AAA_27 PF13514.6 KOO27359.1 - 0.087 12.4 0.1 3 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 KOO27359.1 - 0.12 12.1 0.0 5.7 6.5 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain SRP54 PF00448.22 KOO27359.1 - 0.13 11.9 0.4 8.2 6.0 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_22 PF13401.6 KOO27359.1 - 0.21 11.8 0.8 25 5.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain MukB PF04310.12 KOO27359.1 - 2.5 7.9 4.2 1.6 8.5 0.4 2.4 3 0 0 3 3 3 0 MukB N-terminal DUF4804 PF16062.5 KOO27361.1 - 1.8e-99 333.6 0.0 2.4e-99 333.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4804) Patched PF02460.18 KOO27362.1 - 4.9e-09 34.9 20.0 0.00069 17.8 0.0 2.5 2 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 KOO27362.1 - 0.00031 20.6 23.2 0.0012 18.7 3.3 2.7 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation DUF3899 PF13038.6 KOO27362.1 - 0.029 14.9 0.3 0.69 10.5 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Peptidase_M41 PF01434.18 KOO27363.1 - 8.8e-17 61.6 0.0 9.6e-17 61.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M41 DUF3018 PF11455.8 KOO27364.1 - 0.63 10.0 4.4 2.6 8.1 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3018) Tautomerase PF01361.21 KOO27365.1 - 0.11 12.4 0.1 1.6 8.7 0.1 2.3 2 0 0 2 2 2 0 Tautomerase enzyme HHH_3 PF12836.7 KOO27365.1 - 0.14 12.4 0.1 0.4 11.0 0.1 1.8 2 0 0 2 2 2 0 Helix-hairpin-helix motif LRR_6 PF13516.6 KOO27366.1 - 1.2e-34 115.4 54.3 0.00066 19.5 0.2 16.8 17 0 0 17 17 17 11 Leucine Rich repeat LRR_1 PF00560.33 KOO27366.1 - 4.3e-12 44.8 16.9 9.1 7.3 0.0 12.5 14 1 0 14 14 14 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO27366.1 - 5.3e-11 42.1 19.4 5.9 6.7 0.0 11.2 13 2 0 13 13 13 5 Leucine rich repeat LRR_4 PF12799.7 KOO27366.1 - 3.4e-08 33.7 31.7 1.4 9.4 0.1 10.2 9 2 0 9 9 9 4 Leucine Rich repeats (2 copies) TA_inhibitor PF17574.2 KOO27366.1 - 0.001 19.1 3.8 12 6.0 0.0 6.0 6 0 0 6 6 6 1 Inhibitor of toxin/antitoxin system (Gp4.5) YusW PF14039.6 KOO27366.1 - 0.018 15.6 0.2 69 4.1 0.0 4.1 4 0 0 4 4 4 0 YusW-like protein UPF0181 PF03701.14 KOO27366.1 - 0.037 13.7 3.2 1.2e+02 2.5 0.0 5.1 5 0 0 5 5 5 0 Uncharacterised protein family (UPF0181) RRM PF10378.9 KOO27367.1 - 0.017 14.8 0.9 0.04 13.6 0.9 1.7 1 0 0 1 1 1 0 Putative RRM domain Herpes_BLLF1 PF05109.13 KOO27367.1 - 4 5.3 6.9 4.6 5.1 5.2 1.7 1 1 1 2 2 2 0 Herpes virus major outer envelope glycoprotein (BLLF1) Ribosomal_S15 PF00312.22 KOO27368.1 - 0.054 13.7 0.1 0.054 13.7 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein S15 PAN_4 PF14295.6 KOO27370.1 - 1.3e-07 31.4 6.5 1.3e-07 31.4 6.5 1.9 2 0 0 2 2 2 1 PAN domain Tetraspanin PF00335.20 KOO27370.1 - 0.97 9.1 6.9 1.4 8.6 6.9 1.2 1 0 0 1 1 1 0 Tetraspanin family Baculo_VP91_N PF08475.10 KOO27371.1 - 0.2 11.3 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal Ion_trans PF00520.31 KOO27372.1 - 1.8e-183 607.0 44.1 1.3e-50 172.0 8.1 4.2 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO27372.1 - 5.7e-11 41.8 62.5 1.5e-08 33.8 1.0 8.2 6 3 2 9 9 9 7 Polycystin cation channel GPHH PF16905.5 KOO27372.1 - 2.7e-08 33.4 0.0 6.4e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_6 PF13405.6 KOO27372.1 - 0.043 13.8 0.0 0.16 12.0 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 KOO27372.1 - 0.1 12.2 0.0 0.43 10.2 0.0 2.2 1 0 0 1 1 1 0 EF hand SMBP PF16785.5 KOO27373.1 - 0.00065 19.9 9.6 0.00065 19.9 9.6 2.3 2 0 0 2 2 2 1 Small metal-binding protein Ribosomal_L12 PF00542.19 KOO27373.1 - 0.23 11.8 1.9 0.5 10.8 0.3 2.4 2 1 0 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain DEAD PF00270.29 KOO27374.1 - 0.00012 21.9 0.1 0.00014 21.7 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase TPR_11 PF13414.6 KOO27375.1 - 1.5e-07 31.0 13.0 0.002 17.7 0.0 5.1 6 0 0 6 6 6 2 TPR repeat TPR_14 PF13428.6 KOO27375.1 - 6.1e-06 26.6 26.6 0.0037 17.9 0.0 6.7 6 1 1 7 7 7 3 Tetratricopeptide repeat Utp14 PF04615.13 KOO27375.1 - 0.00078 18.2 1.3 0.001 17.7 1.3 1.2 1 0 0 1 1 1 1 Utp14 protein TPR_17 PF13431.6 KOO27375.1 - 0.0028 17.9 0.0 7.6 7.2 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27375.1 - 0.0057 16.7 13.5 0.14 12.4 0.0 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27375.1 - 0.25 11.7 3.4 14 6.2 0.0 4.5 5 1 0 5 5 5 0 Tetratricopeptide repeat HrcA PF01628.21 KOO27376.1 - 0.0047 16.9 0.2 0.0047 16.9 0.2 2.1 1 1 1 2 2 2 1 HrcA protein C terminal domain Ax_dynein_light PF10211.9 KOO27376.1 - 0.01 15.8 12.8 0.018 15.0 9.1 2.8 2 1 0 2 2 2 0 Axonemal dynein light chain YabA PF06156.13 KOO27376.1 - 0.6 10.8 7.3 0.79 10.4 0.1 3.3 2 1 0 3 3 3 0 Initiation control protein YabA KIP1 PF07765.12 KOO27376.1 - 0.99 9.6 3.9 1.3 9.2 1.6 2.3 2 1 1 3 3 3 0 KIP1-like protein SLX9 PF15341.6 KOO27376.1 - 1.8 9.0 8.2 1.5 9.3 5.7 2.2 2 1 0 2 2 2 0 Ribosome biogenesis protein SLX9 Taxilin PF09728.9 KOO27376.1 - 2.3 7.3 16.1 0.36 10.0 7.1 2.9 3 1 0 3 3 3 0 Myosin-like coiled-coil protein DUF5340 PF17275.2 KOO27376.1 - 2.4 8.4 9.9 0.52 10.5 0.1 3.6 3 1 0 3 3 3 0 Family of unknown function (DUF5340) Prominin PF05478.11 KOO27376.1 - 4.3 5.2 7.5 13 3.6 0.0 2.3 2 1 1 3 3 3 0 Prominin DUF3584 PF12128.8 KOO27376.1 - 6.1 4.2 19.6 5 4.5 15.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Spc24 PF08286.11 KOO27376.1 - 6.8 7.0 11.0 2.9 8.2 0.0 3.3 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 CorA PF01544.18 KOO27376.1 - 7.4 5.8 5.9 3.9 6.7 1.3 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein RCC1 PF00415.18 KOO27377.1 - 4.2e-23 81.7 12.1 4.3e-10 40.0 0.1 5.1 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO27377.1 - 4.7e-11 42.2 24.5 1.9e-05 24.3 0.5 5.9 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Ax_dynein_light PF10211.9 KOO27378.1 - 9.3e-93 309.4 14.2 1.1e-92 309.2 14.2 1.0 1 0 0 1 1 1 1 Axonemal dynein light chain DivIC PF04977.15 KOO27378.1 - 0.019 14.7 5.3 0.019 14.7 5.3 2.9 3 0 0 3 3 3 0 Septum formation initiator BshC PF10079.9 KOO27378.1 - 0.034 12.9 6.4 0.049 12.4 6.4 1.2 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC HALZ PF02183.18 KOO27378.1 - 0.037 14.2 3.2 0.037 14.2 3.2 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper FAM76 PF16046.5 KOO27378.1 - 0.11 11.9 9.4 0.16 11.3 9.4 1.2 1 0 0 1 1 1 0 FAM76 protein EMP24_GP25L PF01105.24 KOO27378.1 - 0.18 11.7 3.1 0.28 11.1 3.1 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD FapA PF03961.13 KOO27378.1 - 0.32 9.6 7.0 0.38 9.3 7.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Jnk-SapK_ap_N PF09744.9 KOO27378.1 - 0.65 10.2 17.2 0.38 11.0 12.4 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 NYD-SP28_assoc PF14775.6 KOO27378.1 - 0.77 9.9 9.7 1.6 8.8 1.4 2.8 2 0 0 2 2 2 0 Sperm tail C-terminal domain UPF0242 PF06785.11 KOO27378.1 - 0.82 9.7 12.0 0.24 11.5 9.4 1.5 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_2 PF07716.15 KOO27378.1 - 1.5 9.0 27.2 0.45 10.6 5.3 2.9 2 1 1 3 3 3 0 Basic region leucine zipper V_ATPase_I PF01496.19 KOO27378.1 - 1.7 6.5 6.3 2.1 6.2 6.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4337 PF14235.6 KOO27378.1 - 2.4 8.2 9.6 2.5 8.2 8.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) FlaC_arch PF05377.11 KOO27378.1 - 2.9 8.3 6.2 5.9 7.4 2.2 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) PRKG1_interact PF15898.5 KOO27378.1 - 5 8.1 16.6 1.7 9.6 13.6 1.8 2 0 0 2 2 1 0 cGMP-dependent protein kinase interacting domain APG6_N PF17675.1 KOO27378.1 - 6.1 7.4 23.8 31 5.1 24.2 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF5320 PF17253.2 KOO27378.1 - 7.7 7.7 12.5 10 7.2 4.5 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5320) PKK PF12474.8 KOO27378.1 - 9.3 6.4 25.9 0.21 11.7 19.4 1.5 2 0 0 2 2 2 0 Polo kinase kinase O-FucT PF10250.9 KOO27379.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase Peptidase_S41 PF03572.18 KOO27380.1 - 5.5e-38 130.1 0.0 8e-38 129.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S41 PDZ_6 PF17820.1 KOO27380.1 - 2.5e-10 40.1 1.3 4.1e-10 39.3 0.2 2.1 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO27380.1 - 2.9e-06 27.5 0.0 7e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO27380.1 - 1.7e-05 25.1 0.0 3.6e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Tricorn_C1 PF14684.6 KOO27380.1 - 0.0015 18.5 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 Tricorn protease C1 domain Tricorn_PDZ PF14685.6 KOO27380.1 - 0.021 14.8 0.0 0.051 13.5 0.0 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain GRASP55_65 PF04495.14 KOO27380.1 - 0.14 12.5 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain ArgoL2 PF16488.5 KOO27380.1 - 0.14 12.5 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 Argonaute linker 2 domain Thioredoxin_6 PF13848.6 KOO27381.1 - 2.4e-12 47.1 0.0 4.1e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Calreticulin PF00262.18 KOO27381.1 - 1.9e-05 23.7 0.1 3.2e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Calreticulin family Glyco_transf_28 PF03033.20 KOO27382.1 - 1.5e-12 47.8 0.0 4.1e-12 46.3 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PaREP1 PF05942.11 KOO27382.1 - 0.077 12.9 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Archaeal PaREP1/PaREP8 family DUF4112 PF13430.6 KOO27382.1 - 0.12 12.6 0.4 0.24 11.7 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4112) Se-cys_synth_N PF12390.8 KOO27382.1 - 0.43 10.8 3.8 1.9 8.8 0.8 2.7 2 0 0 2 2 2 0 Selenocysteine synthase N terminal Dus PF01207.17 KOO27383.1 - 7.1e-53 179.7 0.0 1.6e-52 178.6 0.0 1.5 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) ThiG PF05690.14 KOO27383.1 - 0.0084 15.4 1.1 0.0088 15.4 0.0 1.5 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG FMN_dh PF01070.18 KOO27383.1 - 0.015 14.4 0.3 0.034 13.2 0.2 1.6 1 1 0 1 1 1 0 FMN-dependent dehydrogenase ZapB PF06005.12 KOO27383.1 - 0.096 13.1 1.3 0.26 11.7 1.3 1.6 1 0 0 1 1 1 0 Cell division protein ZapB EF-hand_7 PF13499.6 KOO27384.1 - 0.094 13.2 0.1 0.21 12.1 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair Myb_DNA-binding PF00249.31 KOO27386.1 - 1.1e-32 112.0 1.8 8.5e-16 57.9 0.1 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO27386.1 - 1.5e-21 76.4 0.2 2.2e-10 40.6 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 KOO27386.1 - 1.5e-06 28.2 0.0 0.018 15.1 0.1 2.2 1 1 1 2 2 2 2 SLIDE Myb_DNA-bind_7 PF15963.5 KOO27386.1 - 5e-05 23.1 0.0 0.00017 21.4 0.0 1.7 2 0 0 2 2 2 1 Myb DNA-binding like Rap1_C PF11626.8 KOO27386.1 - 0.0014 18.6 0.7 0.66 10.1 0.3 2.3 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.11 KOO27386.1 - 0.0043 17.2 1.2 0.45 10.7 0.3 2.8 1 1 1 2 2 2 1 Rap1 Myb domain SANT_DAMP1_like PF16282.5 KOO27386.1 - 0.031 14.4 0.1 0.094 12.9 0.1 1.7 1 1 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Dus PF01207.17 KOO27387.1 - 1.9e-56 191.5 0.0 2.5e-56 191.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) UCH PF00443.29 KOO27388.1 - 2e-44 152.0 0.0 2.5e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO27388.1 - 5e-13 49.3 0.0 1.3e-12 48.0 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 KOO27388.1 - 4.8e-08 32.6 0.0 1e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Peptidase_C98 PF15499.6 KOO27388.1 - 0.0076 15.8 0.0 0.065 12.7 0.0 2.2 2 1 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase LRR_8 PF13855.6 KOO27389.1 - 8.3e-22 76.7 9.6 7.1e-07 28.9 0.2 5.0 3 1 3 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 KOO27389.1 - 4.4e-20 71.4 9.2 0.00045 20.6 0.3 6.1 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO27389.1 - 0.00019 21.5 11.2 2.2 9.2 0.1 7.4 8 1 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 KOO27389.1 - 0.0041 16.7 0.2 7.1 6.1 0.0 3.2 1 1 2 3 3 3 2 Leucine-rich repeat Beta_helix PF13229.6 KOO27391.1 - 1.8e-22 79.9 0.0 1.4e-12 47.8 0.0 2.2 1 1 1 2 2 2 2 Right handed beta helix region TRM PF02005.16 KOO27391.1 - 1.8e-21 76.8 0.0 7.3e-11 41.8 0.0 2.2 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase NosD PF05048.13 KOO27391.1 - 1.1e-12 47.7 0.0 2.5e-08 33.5 0.0 2.1 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.11 KOO27391.1 - 0.0013 18.2 0.1 0.09 12.1 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1565) Adeno_E1B_55K PF01696.17 KOO27391.1 - 0.017 13.8 6.2 0.2 10.3 0.1 2.3 2 0 0 2 2 2 0 Adenovirus EB1 55K protein / large t-antigen Bromodomain PF00439.25 KOO27392.1 - 1.3e-11 44.4 0.0 2.5e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Bromodomain HMG_box PF00505.19 KOO27392.1 - 1.6e-07 31.6 3.4 4.1e-07 30.3 3.4 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO27392.1 - 8.1e-06 26.3 3.5 2.2e-05 25.0 3.5 1.8 1 0 0 1 1 1 1 HMG-box domain Myc_N PF01056.18 KOO27392.1 - 0.0054 16.7 4.9 0.0054 16.7 4.9 2.9 2 1 1 3 3 3 1 Myc amino-terminal region FAM60A PF15396.6 KOO27392.1 - 1.2 9.1 11.7 5.4 6.9 2.0 2.5 2 0 0 2 2 2 0 Protein Family FAM60A Mpp10 PF04006.12 KOO27392.1 - 2 6.8 22.4 0.61 8.5 4.4 2.4 2 0 0 2 2 2 0 Mpp10 protein Ion_trans_2 PF07885.16 KOO27393.1 - 9.2e-27 92.8 22.8 3.1e-13 49.5 9.8 2.4 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KOO27393.1 - 4.6e-05 22.8 4.9 0.0096 15.2 0.2 2.4 2 1 0 2 2 2 2 Ion transport protein DUF3452 PF11934.8 KOO27393.1 - 0.016 14.7 0.5 0.087 12.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) DUF4763 PF15960.5 KOO27393.1 - 0.29 10.4 2.8 0.17 11.1 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) DHO_dh PF01180.21 KOO27394.1 - 2.1e-31 109.2 0.0 5.4e-31 107.9 0.0 1.5 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase Cupin_4 PF08007.12 KOO27396.1 - 2.7e-20 73.1 0.0 8.4e-20 71.5 0.0 1.8 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 KOO27396.1 - 2.5e-08 34.0 0.0 3.8e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 Cupin-like domain Death PF00531.22 KOO27396.1 - 0.12 12.5 0.1 0.48 10.6 0.0 1.9 1 1 1 2 2 2 0 Death domain Neur_chan_memb PF02932.16 KOO27397.1 - 2.8e-07 30.9 16.3 3.4e-07 30.6 6.1 2.4 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DivIVA PF05103.13 KOO27397.1 - 0.32 11.1 13.1 0.53 10.4 13.1 1.3 1 0 0 1 1 1 0 DivIVA protein DUF4407 PF14362.6 KOO27397.1 - 1.8 7.9 8.7 2.7 7.2 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 KOO27397.1 - 2.3 8.0 10.6 4 7.2 10.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ATP-synt_B PF00430.18 KOO27397.1 - 5.4 7.1 21.6 11 6.2 21.6 1.4 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Vfa1 PF08432.10 KOO27397.1 - 7.1 6.9 13.4 15 5.9 13.4 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RNA_pol_Rpc4 PF05132.14 KOO27397.1 - 8.6 6.8 10.4 22 5.5 10.4 1.7 1 0 0 1 1 1 0 RNA polymerase III RPC4 ADK PF00406.22 KOO27398.1 - 0.15 12.1 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Adenylate kinase zf-CCCH_4 PF18044.1 KOO27399.1 - 0.03 14.1 4.3 0.2 11.5 4.3 2.1 1 1 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOO27399.1 - 0.06 13.4 4.5 1.2 9.3 0.6 2.3 2 0 0 2 2 2 0 Zinc finger domain cobW PF02492.19 KOO27400.1 - 4.7e-23 81.7 0.1 7.4e-23 81.0 0.1 1.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MORN PF02493.20 KOO27401.1 - 2.6e-22 77.3 17.0 1.8e-07 30.6 1.1 4.2 4 0 0 4 4 4 3 MORN repeat cobW PF02492.19 KOO27401.1 - 7.4e-18 64.7 0.0 1.2e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 KOO27401.1 - 0.00061 20.2 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO27401.1 - 0.0023 18.2 0.0 0.0048 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KOO27401.1 - 0.0055 16.6 0.0 0.0086 16.0 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase TsaE PF02367.17 KOO27401.1 - 0.02 14.9 0.0 0.038 14.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 KOO27401.1 - 0.03 13.4 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF1990 PF09348.10 KOO27401.1 - 0.045 13.8 0.1 0.1 12.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1990) ABC_tran PF00005.27 KOO27401.1 - 0.058 13.9 0.0 0.14 12.7 0.0 1.6 2 0 0 2 2 1 0 ABC transporter ATPase_2 PF01637.18 KOO27401.1 - 0.065 13.1 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 KOO27401.1 - 0.084 13.0 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOO27401.1 - 0.092 12.8 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 KOO27401.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.6 KOO27401.1 - 0.12 12.1 0.2 0.55 10.0 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 KOO27401.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase SRPRB PF09439.10 KOO27401.1 - 0.22 10.9 0.0 0.37 10.2 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF3048_C PF17479.2 KOO27401.1 - 2.1 8.8 5.3 19 5.7 0.4 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3048) C-terminal domain F_bP_aldolase PF01116.20 KOO27402.1 - 1.9e-40 139.1 0.0 1e-38 133.5 0.0 2.0 1 1 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Aminotran_1_2 PF00155.21 KOO27403.1 - 1.1e-31 110.3 0.0 1.3e-31 110.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KOO27403.1 - 0.00044 18.9 0.0 0.00061 18.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 KOO27403.1 - 0.00047 19.5 0.0 0.00061 19.2 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Alliinase_C PF04864.13 KOO27403.1 - 0.00058 18.9 0.0 0.00083 18.3 0.0 1.2 1 0 0 1 1 1 1 Allinase DegT_DnrJ_EryC1 PF01041.17 KOO27403.1 - 0.0033 16.8 0.0 0.0069 15.7 0.1 1.4 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 KOO27403.1 - 0.0043 16.1 0.0 0.0061 15.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DUF4072 PF13284.6 KOO27403.1 - 0.093 13.2 0.1 0.33 11.4 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4072) Mitoc_mL59 PF18126.1 KOO27404.1 - 8e-10 39.1 6.9 5.2e-08 33.3 6.9 2.1 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 CR6_interact PF10147.9 KOO27404.1 - 0.0023 17.7 1.0 0.0028 17.4 1.0 1.2 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF3106 PF11304.8 KOO27404.1 - 0.01 16.3 1.2 0.019 15.4 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) IL10 PF00726.17 KOO27407.1 - 0.076 12.5 2.6 0.088 12.3 0.7 1.9 2 0 0 2 2 2 0 Interleukin 10 Fea1 PF07692.11 KOO27407.1 - 0.12 11.4 1.6 0.17 10.9 0.4 1.7 1 1 1 2 2 2 0 Low iron-inducible periplasmic protein DUF4407 PF14362.6 KOO27407.1 - 4.9 6.4 22.6 8 5.7 22.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Asp-B-Hydro_N PF05279.11 KOO27407.1 - 5.5 7.0 14.6 0.34 10.9 9.1 1.7 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Nucleotid_trans PF03407.16 KOO27408.1 - 7e-34 117.7 0.0 1e-33 117.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase FmiP_Thoc5 PF09766.9 KOO27410.1 - 9.4e-42 143.6 0.4 1.2e-41 143.2 0.4 1.1 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 Sigma70_r1_2 PF00140.20 KOO27410.1 - 4.7 7.3 5.5 4.2 7.5 0.4 2.9 3 0 0 3 3 3 0 Sigma-70 factor, region 1.2 PDEase_I PF00233.19 KOO27411.1 - 2.5e-61 207.5 0.0 3.4e-59 200.5 0.0 2.1 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase PDZ PF00595.24 KOO27412.1 - 1.4e-08 34.9 0.0 2.5e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO27412.1 - 3.8e-05 23.4 0.3 7.2e-05 22.6 0.3 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO27412.1 - 0.079 13.3 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 PDZ domain Adeno_E3_CR2 PF02439.15 KOO27412.1 - 0.12 12.1 0.3 0.27 11.0 0.3 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 HCMV_UL139 PF12507.8 KOO27413.1 - 0.0047 17.3 3.1 0.0047 17.3 3.1 2.8 1 1 1 2 2 2 1 Human Cytomegalovirus UL139 protein Tup_N PF08581.10 KOO27413.1 - 0.58 10.5 9.0 2.4 8.5 0.1 4.0 3 2 1 5 5 5 0 Tup N-terminal FlaC_arch PF05377.11 KOO27413.1 - 2.7 8.5 6.5 2.9 8.4 0.1 2.9 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Patched PF02460.18 KOO27414.1 - 0.61 8.1 10.6 0.13 10.3 4.0 2.1 2 0 0 2 2 2 0 Patched family PI3_PI4_kinase PF00454.27 KOO27415.1 - 3.5e-26 92.5 0.0 1.8e-21 77.1 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PH PF00169.29 KOO27415.1 - 1.4e-15 57.7 0.0 4.3e-15 56.1 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 KOO27415.1 - 1.4e-07 31.8 0.0 2.9e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KOO27415.1 - 8e-05 23.0 0.0 0.00021 21.7 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Patatin PF01734.22 KOO27415.1 - 0.016 15.4 2.4 0.46 10.6 0.4 2.9 2 1 1 3 3 3 0 Patatin-like phospholipase Beta-lactamase PF00144.24 KOO27416.1 - 7.5e-14 51.7 0.2 2.8e-13 49.8 0.2 1.9 1 1 0 1 1 1 1 Beta-lactamase AA_kinase PF00696.28 KOO27417.1 - 3.2e-46 157.9 0.0 5.5e-46 157.1 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 KOO27417.1 - 1.9e-09 37.1 0.8 7.6e-05 22.4 0.1 2.5 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 KOO27417.1 - 5.9e-05 22.8 2.6 0.005 16.6 0.7 2.5 2 0 0 2 2 2 2 ACT domain RRF PF01765.19 KOO27417.1 - 0.09 12.7 0.2 0.18 11.7 0.2 1.5 1 0 0 1 1 1 0 Ribosome recycling factor EF-hand_6 PF13405.6 KOO27418.1 - 7.1e-23 78.5 4.9 0.00034 20.3 0.0 4.9 4 1 1 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 KOO27418.1 - 8.1e-21 72.0 7.9 0.00012 21.4 0.0 4.6 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO27418.1 - 4e-16 59.2 8.5 1.4e-06 28.7 0.1 3.4 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO27418.1 - 1.6e-15 56.7 0.8 4.2e-06 26.5 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO27418.1 - 1.8e-07 30.4 7.7 0.32 10.6 0.1 5.4 5 0 0 5 5 5 4 EF hand EF-hand_11 PF08976.11 KOO27418.1 - 3.1e-05 24.8 0.0 0.017 16.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_9 PF14658.6 KOO27418.1 - 0.00068 19.9 0.0 1.5 9.2 0.0 4.0 4 0 0 4 4 4 1 EF-hand domain Caleosin PF05042.13 KOO27418.1 - 0.023 14.6 0.1 1.9 8.4 0.0 2.7 2 1 1 3 3 3 0 Caleosin related protein PMBR PF09373.10 KOO27418.1 - 0.033 14.3 0.5 1e+02 3.3 0.0 4.1 4 0 0 4 4 4 0 Pseudomurein-binding repeat Ion_trans PF00520.31 KOO27419.1 - 5.5e-95 317.2 17.5 2e-51 174.6 0.1 2.0 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 KOO27419.1 - 4.1e-05 22.4 31.1 0.11 11.2 2.4 4.9 3 1 1 4 4 4 3 Polycystin cation channel TIM21 PF08294.11 KOO27419.1 - 0.026 14.4 0.8 13 5.6 0.0 3.3 3 0 0 3 3 3 0 TIM21 DUF1180 PF06679.12 KOO27419.1 - 0.15 12.4 1.1 0.52 10.7 1.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3787 PF12655.7 KOO27419.1 - 0.3 11.0 2.7 6.7 6.7 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3787) DUF4834 PF16118.5 KOO27419.1 - 1.5 9.8 4.0 1.6 9.7 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) ATP-synt_Eps PF04627.13 KOO27420.1 - 0.11 12.4 0.5 0.3 11.1 0.5 1.8 1 0 0 1 1 1 0 Mitochondrial ATP synthase epsilon chain Syntaxin-6_N PF09177.11 KOO27422.1 - 6.4e-16 58.7 3.8 6.4e-15 55.5 0.8 2.5 2 1 0 2 2 2 1 Syntaxin 6, N-terminal Mis14 PF08641.12 KOO27422.1 - 0.028 14.7 1.2 0.028 14.7 1.2 2.0 2 1 0 2 2 2 0 Kinetochore protein Mis14 like Retrotran_gag_2 PF14223.6 KOO27422.1 - 0.095 12.4 1.5 0.23 11.1 0.4 2.0 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type SNARE PF05739.19 KOO27422.1 - 0.14 12.1 2.1 0.65 10.0 0.0 3.1 4 0 0 4 4 4 0 SNARE domain Macoilin PF09726.9 KOO27422.1 - 4.5 5.7 7.8 7 5.1 7.8 1.3 1 1 0 1 1 1 0 Macoilin family Aminotran_3 PF00202.21 KOO27423.1 - 1.4e-12 47.0 0.1 5.7e-11 41.7 0.1 2.2 1 1 0 1 1 1 1 Aminotransferase class-III PG_isomerase_N PF18353.1 KOO27423.1 - 0.029 14.7 2.4 0.066 13.6 0.8 2.5 2 0 0 2 2 2 0 Phosphoglucose isomerase N-terminal domain GTP1_OBG PF01018.22 KOO27424.1 - 8.6e-50 168.3 5.7 1.5e-49 167.5 5.7 1.4 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 KOO27424.1 - 3.2e-23 82.0 0.0 5e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1967 PF09269.11 KOO27424.1 - 5.5e-17 61.5 0.0 1.2e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1967) FeoB_N PF02421.18 KOO27424.1 - 1.4e-08 34.5 0.0 3.4e-08 33.2 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 KOO27424.1 - 0.0066 16.0 0.0 0.34 10.4 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 KOO27424.1 - 0.013 14.5 0.0 3.4 6.6 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 KOO27424.1 - 0.095 12.5 0.0 1.5 8.5 0.0 2.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 KOO27424.1 - 0.15 12.6 0.0 0.36 11.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter DnaJ PF00226.31 KOO27425.1 - 3.1e-12 46.4 0.0 5.5e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Rhodanese PF00581.20 KOO27425.1 - 1.8e-08 34.8 0.0 3.5e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain HAD PF12710.7 KOO27427.1 - 0.14 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HhH-GPD PF00730.25 KOO27428.1 - 7.2e-14 52.2 0.0 1e-13 51.7 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NeA_P2 PF12312.8 KOO27428.1 - 0.035 13.6 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein Atg14 PF10186.9 KOO27430.1 - 0.0017 17.5 5.0 0.0017 17.5 5.0 5.2 4 2 1 6 6 6 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc29 PF17082.5 KOO27430.1 - 0.052 13.4 0.3 0.19 11.6 0.3 2.0 1 0 0 1 1 1 0 Spindle Pole Component 29 FAM76 PF16046.5 KOO27430.1 - 0.053 12.9 0.1 0.053 12.9 0.1 4.0 4 1 1 5 5 5 0 FAM76 protein betaPIX_CC PF16523.5 KOO27430.1 - 0.095 12.5 8.5 0.59 10.0 8.5 2.4 1 0 0 1 1 1 0 betaPIX coiled coil NPV_P10 PF05531.12 KOO27430.1 - 0.14 12.6 3.2 2.7 8.5 0.4 3.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Tho2 PF11262.8 KOO27430.1 - 0.22 10.7 2.4 0.82 8.8 2.4 2.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF1664 PF07889.12 KOO27430.1 - 1.7 8.7 7.5 3 7.9 0.3 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) MPS2 PF17060.5 KOO27430.1 - 1.7 7.8 9.7 0.1 11.8 0.9 2.9 3 0 0 3 3 3 0 Monopolar spindle protein 2 Baculo_PEP_C PF04513.12 KOO27430.1 - 2.2 8.3 10.9 0.97 9.5 1.6 3.9 2 2 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus RACo_linker PF17650.1 KOO27430.1 - 2.6 8.0 6.8 2.7 7.9 0.1 3.7 3 0 0 3 3 3 0 RACo linker region TolA_bind_tri PF16331.5 KOO27430.1 - 3.3 7.9 23.8 4.7 7.4 0.1 4.8 4 2 1 5 5 5 0 TolA binding protein trimerisation Coa1 PF08695.10 KOO27431.1 - 0.16 11.7 0.0 16 5.3 0.0 3.0 2 1 0 2 2 2 0 Cytochrome oxidase complex assembly protein 1 cNMP_binding PF00027.29 KOO27432.1 - 2e-15 56.6 0.1 5.9e-15 55.1 0.0 1.9 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain bPH_2 PF03703.14 KOO27432.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial PH domain Chlorophyllase2 PF12740.7 KOO27433.1 - 1.9e-08 33.5 0.0 2.9e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 KOO27433.1 - 0.00054 19.1 0.0 0.0009 18.3 0.0 1.3 1 1 0 1 1 1 1 Chlorophyllase Abhydrolase_5 PF12695.7 KOO27433.1 - 0.0011 18.8 0.1 0.068 12.9 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOO27433.1 - 0.002 17.6 0.2 0.63 9.5 0.1 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 KOO27433.1 - 0.0026 17.4 0.0 0.0043 16.6 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 KOO27433.1 - 0.0074 16.2 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold PAF-AH_p_II PF03403.13 KOO27433.1 - 0.018 13.6 0.6 0.75 8.2 0.0 2.1 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Hydrolase_4 PF12146.8 KOO27433.1 - 0.02 14.2 0.5 0.69 9.1 0.0 2.2 1 1 1 2 2 2 0 Serine aminopeptidase, S33 FSH1 PF03959.13 KOO27433.1 - 0.036 13.7 0.0 0.05 13.3 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) AXE1 PF05448.12 KOO27433.1 - 0.15 10.7 0.0 0.31 9.7 0.0 1.5 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) Metallophos PF00149.28 KOO27434.1 - 2.6e-22 80.3 0.5 4.9e-22 79.4 0.5 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_7 PF13499.6 KOO27434.1 - 1.6e-13 50.9 0.0 6.6e-05 23.3 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO27434.1 - 3.1e-12 45.4 0.2 0.005 16.7 0.0 5.9 6 0 0 6 6 6 2 EF-hand domain EF-hand_1 PF00036.32 KOO27434.1 - 1.3e-11 43.2 0.0 0.0013 18.2 0.0 6.0 7 0 0 7 7 7 2 EF hand EF-hand_8 PF13833.6 KOO27434.1 - 4e-08 33.0 0.4 0.15 11.9 0.1 5.3 7 0 0 7 7 7 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO27434.1 - 0.00013 21.3 0.3 0.27 10.8 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KOO27436.1 - 1.3e-10 41.6 0.6 2.3e-10 40.8 0.6 1.4 1 0 0 1 1 1 1 EF-hand domain pair Na_Ca_ex PF01699.24 KOO27436.1 - 7.1e-10 39.0 29.9 4.3e-07 30.0 12.6 2.9 2 1 1 3 3 3 2 Sodium/calcium exchanger protein EF-hand_1 PF00036.32 KOO27436.1 - 1.5e-08 33.6 0.3 0.00089 18.6 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO27436.1 - 2.2e-07 30.3 0.2 0.0075 16.1 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO27436.1 - 0.0022 17.8 0.3 0.0061 16.4 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO27436.1 - 0.026 14.0 0.2 3.1 7.5 0.1 2.5 2 0 0 2 2 2 0 EF hand Cpn60_TCP1 PF00118.24 KOO27438.1 - 7.8e-156 519.5 9.0 9.9e-156 519.2 9.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MOSC PF03473.17 KOO27439.1 - 0.018 15.1 0.6 0.051 13.6 0.6 1.8 1 1 0 1 1 1 0 MOSC domain FAST_1 PF06743.15 KOO27440.1 - 5.3e-13 48.7 0.7 0.023 14.6 0.0 4.5 1 1 2 4 4 4 4 FAST kinase-like protein, subdomain 1 GrpE PF01025.19 KOO27441.1 - 1.6e-31 109.2 3.6 3.7e-31 108.0 3.5 1.6 1 1 0 1 1 1 1 GrpE Mod_r PF07200.13 KOO27441.1 - 0.0077 16.3 6.4 0.012 15.7 6.4 1.3 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein OrfB_IS605 PF01385.19 KOO27441.1 - 0.058 13.6 1.0 0.13 12.4 0.9 1.6 2 0 0 2 2 2 0 Probable transposase Fib_alpha PF08702.10 KOO27441.1 - 0.065 13.4 0.4 0.096 12.9 0.4 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 KOO27441.1 - 0.094 12.8 12.7 0.24 11.5 12.6 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein KELK PF15796.5 KOO27441.1 - 0.33 11.4 6.3 0.62 10.6 6.3 1.6 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase APG6_N PF17675.1 KOO27441.1 - 0.34 11.4 15.9 0.6 10.6 14.5 1.9 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4407 PF14362.6 KOO27441.1 - 0.38 10.1 8.2 0.52 9.6 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 KOO27441.1 - 0.49 11.1 3.1 0.81 10.4 2.8 1.7 1 1 0 1 1 1 0 Initiation control protein YabA Atg14 PF10186.9 KOO27441.1 - 0.79 8.8 3.3 0.88 8.6 3.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlxA PF14282.6 KOO27441.1 - 1.1 9.3 6.1 1.5 8.8 5.1 1.7 1 1 0 1 1 1 0 FlxA-like protein Sigma70_ner PF04546.13 KOO27441.1 - 2.8 7.8 12.2 13 5.6 0.0 2.1 1 1 1 2 2 2 0 Sigma-70, non-essential region AAA_12 PF13087.6 KOO27442.1 - 1.9e-22 79.9 0.0 2.7e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain RNase_H_2 PF13482.6 KOO27442.1 - 2.8e-17 63.2 0.0 4.5e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 RNase_H superfamily AAA_30 PF13604.6 KOO27442.1 - 9.4e-12 45.0 3.2 1.2e-06 28.4 0.5 2.6 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 KOO27442.1 - 7e-11 42.4 0.5 0.00017 21.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KOO27442.1 - 8e-09 36.0 0.0 1.7e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 KOO27442.1 - 7.4e-05 22.7 0.6 0.11 12.4 0.1 2.3 2 0 0 2 2 2 2 Helicase AAA PF00004.29 KOO27442.1 - 0.006 17.0 0.0 0.14 12.6 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 KOO27442.1 - 0.0076 15.3 0.1 0.014 14.4 0.1 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 KOO27442.1 - 0.0079 16.6 0.7 0.077 13.4 0.7 2.8 1 1 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 KOO27442.1 - 0.0087 15.3 0.0 0.021 14.1 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 KOO27442.1 - 0.019 15.0 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit UvrD_C_2 PF13538.6 KOO27442.1 - 0.027 14.3 0.0 0.42 10.5 0.0 2.6 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_5 PF07728.14 KOO27442.1 - 0.032 14.2 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KOO27442.1 - 0.037 13.7 0.1 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_22 PF13401.6 KOO27442.1 - 0.045 14.0 0.1 0.18 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain PIF1 PF05970.14 KOO27442.1 - 0.05 12.8 0.0 0.078 12.1 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase MobB PF03205.14 KOO27442.1 - 0.2 11.5 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Med26 PF08711.11 KOO27443.1 - 1.7e-12 47.2 0.1 4.3e-12 45.9 0.1 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DUF1464 PF07318.12 KOO27443.1 - 0.92 8.6 3.9 3.2 6.8 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1464) TRAM_LAG1_CLN8 PF03798.16 KOO27444.1 - 8.5e-16 58.3 7.7 1.3e-15 57.7 7.7 1.3 1 0 0 1 1 1 1 TLC domain WIF PF02019.18 KOO27445.1 - 0.081 12.6 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 WIF domain Melibiase_C PF17801.1 KOO27447.1 - 1.3e-07 31.6 1.0 2.6e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Glyco_hydro_79n PF03662.14 KOO27447.1 - 0.00049 19.1 0.2 0.58 9.0 0.0 3.1 1 1 2 3 3 3 2 Glycosyl hydrolase family 79, N-terminal domain PAN_4 PF14295.6 KOO27447.1 - 0.00095 19.0 1.1 0.00095 19.0 1.1 2.0 3 0 0 3 3 3 1 PAN domain Melibiase_2_C PF17450.2 KOO27447.1 - 0.14 12.4 0.0 0.43 10.8 0.0 1.8 2 0 0 2 2 2 0 Alpha galactosidase A C-terminal beta sandwich domain P2X_receptor PF00864.19 KOO27448.1 - 2.3e-08 33.5 3.9 2.8e-05 23.4 2.9 2.4 2 1 0 2 2 2 2 ATP P2X receptor FixP_N PF14715.6 KOO27448.1 - 2.9 7.7 6.3 5.4 6.8 6.3 1.4 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP TPT PF03151.16 KOO27449.1 - 6.7e-07 28.9 2.7 8e-07 28.7 2.7 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family Trs65 PF12735.7 KOO27451.1 - 9.2e-13 48.3 0.2 4.9e-08 32.7 0.0 2.0 2 0 0 2 2 2 2 TRAPP trafficking subunit Trs65 Transglut_C PF00927.22 KOO27451.1 - 0.0017 18.4 0.1 0.0039 17.3 0.1 1.6 1 1 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain DUF974 PF06159.13 KOO27451.1 - 0.012 15.5 0.1 0.031 14.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF974) IlvB_leader PF08049.11 KOO27451.1 - 0.021 14.8 0.3 0.039 13.9 0.3 1.5 1 0 0 1 1 1 0 IlvB leader peptide DUF974 PF06159.13 KOO27452.1 - 6.9e-38 130.8 0.0 7.4e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) DUF2108 PF09881.9 KOO27452.1 - 0.073 13.0 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2108) CPSF100_C PF13299.6 KOO27453.1 - 6e-19 68.8 0.6 5.6e-16 59.2 0.1 2.6 2 1 1 3 3 3 2 Cleavage and polyadenylation factor 2 C-terminal RMMBL PF07521.12 KOO27453.1 - 2.1e-10 40.4 0.1 6.1e-10 38.9 0.0 1.8 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 KOO27454.1 - 5.8e-47 159.6 0.0 7.7e-47 159.2 0.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 KOO27454.1 - 1.2e-09 38.5 0.0 2.1e-09 37.7 0.0 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOO27454.1 - 8.5e-07 28.7 0.4 2.5e-06 27.2 0.2 1.8 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KOO27454.1 - 0.00041 20.3 0.0 0.001 19.0 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta-Casp PF10996.8 KOO27454.1 - 0.0016 18.7 0.0 0.0054 17.0 0.0 1.8 2 0 0 2 2 2 1 Beta-Casp domain NAD_binding_3 PF03447.16 KOO27454.1 - 0.11 13.2 0.1 0.29 11.8 0.0 1.8 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Nucleotid_trans PF03407.16 KOO27455.1 - 5.5e-19 69.0 0.1 1.9e-18 67.2 0.1 1.8 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Sulfotransfer_2 PF03567.14 KOO27456.1 - 0.0017 18.3 0.0 0.0035 17.3 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family Peptidase_M24 PF00557.24 KOO27457.1 - 1.2e-53 182.0 0.1 1.4e-53 181.7 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 WD40 PF00400.32 KOO27458.1 - 1.9e-16 60.1 6.6 0.00071 20.3 0.1 8.9 8 1 1 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO27458.1 - 1e-05 25.8 0.0 2.1 8.7 0.0 5.4 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Fez1 PF06818.15 KOO27458.1 - 9.6e-05 22.9 8.3 9.6e-05 22.9 8.3 4.9 1 1 3 4 4 4 2 Fez1 NHL PF01436.21 KOO27460.1 - 2.1e-06 27.5 3.0 1.1 9.4 0.0 5.5 6 1 0 6 6 6 3 NHL repeat DUF5128 PF17170.4 KOO27460.1 - 3.1e-05 23.3 0.0 5.2e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 6-bladed beta-propeller TolB_like PF15869.5 KOO27460.1 - 0.0017 17.6 0.0 0.0031 16.8 0.0 1.3 1 0 0 1 1 1 1 TolB-like 6-blade propeller-like DUF2252 PF10009.9 KOO27461.1 - 2.5e-57 194.7 1.4 3.6e-57 194.2 1.4 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2252) GRP PF07172.11 KOO27462.1 - 0.0028 18.3 3.6 0.0067 17.1 3.6 1.6 1 0 0 1 1 1 1 Glycine rich protein family FUSC PF04632.12 KOO27462.1 - 4.8 5.6 21.7 6.1 5.3 21.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Chloroa_b-bind PF00504.21 KOO27463.1 - 4.5e-26 92.3 0.1 6e-26 91.9 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein LRR_6 PF13516.6 KOO27464.1 - 9e-08 31.6 1.7 0.07 13.2 0.1 4.9 5 0 0 5 5 5 3 Leucine Rich repeat Sas10 PF09368.10 KOO27467.1 - 5.4e-23 81.3 6.8 5.4e-23 81.3 6.8 2.5 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 KOO27467.1 - 2.6e-19 69.6 0.7 7.3e-19 68.2 0.7 1.9 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF1932 PF09130.11 KOO27467.1 - 0.0081 16.1 3.6 0.0098 15.8 0.6 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1932) TRIQK PF15168.6 KOO27467.1 - 0.057 13.3 0.2 0.25 11.3 0.2 2.1 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family FANCD2OS PF15124.6 KOO27467.1 - 0.099 12.8 0.3 0.22 11.7 0.3 1.5 1 0 0 1 1 1 0 FANCD2 opposite strand protein Peptidase_M23 PF01551.22 KOO27468.1 - 2.8e-18 65.9 0.0 4.6e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M23 Mg_trans_NIPA PF05653.14 KOO27469.1 - 6.9e-49 166.5 17.2 5.2e-48 163.7 17.2 2.2 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KOO27469.1 - 1.4e-06 28.6 9.5 1.4e-06 28.6 9.5 3.0 3 1 0 3 3 3 1 EamA-like transporter family GTP_EFTU PF00009.27 KOO27470.1 - 9.2e-55 185.2 0.0 1.1e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 KOO27470.1 - 1.5e-21 76.3 0.0 2.9e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KOO27470.1 - 5.2e-20 71.3 0.0 9.7e-20 70.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus RF3_C PF16658.5 KOO27470.1 - 3.8e-05 23.5 0.0 7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 KOO27470.1 - 0.027 14.5 0.1 0.047 13.8 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase CAP59_mtransfer PF11735.8 KOO27471.1 - 0.034 13.8 0.0 0.036 13.8 0.0 1.1 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 DUF3605 PF12239.8 KOO27472.1 - 7e-05 23.2 0.1 0.00034 21.0 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3605) Aa_trans PF01490.18 KOO27473.1 - 1.1e-58 198.9 22.0 1.4e-58 198.6 22.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOO27473.1 - 2.3e-14 53.3 17.1 2.3e-14 53.3 17.1 2.1 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Anoctamin PF04547.12 KOO27475.1 - 3.6e-101 339.2 13.0 5.2e-101 338.7 13.0 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel cobW PF02492.19 KOO27475.1 - 1.7e-51 174.3 1.4 2.9e-51 173.5 1.4 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SNF2_N PF00176.23 KOO27475.1 - 4.1e-44 150.7 0.4 1.2e-43 149.2 0.0 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO27475.1 - 3.1e-18 66.1 0.0 4.1e-17 62.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CobW_C PF07683.14 KOO27475.1 - 7.1e-13 48.3 0.0 2.7e-12 46.4 0.0 2.1 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain DEAD PF00270.29 KOO27475.1 - 0.00019 21.3 0.0 0.00055 19.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOO27475.1 - 0.00054 20.3 0.1 0.78 10.0 0.0 3.5 4 0 0 4 4 4 1 AAA domain AAA_34 PF13872.6 KOO27475.1 - 0.00055 18.9 0.2 0.003 16.5 0.1 2.3 2 1 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 SEC-C PF02810.15 KOO27475.1 - 0.0059 16.5 6.7 0.014 15.3 6.7 1.6 1 0 0 1 1 1 1 SEC-C motif AAA_16 PF13191.6 KOO27475.1 - 0.0081 16.6 0.4 0.19 12.1 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain Anoct_dimer PF16178.5 KOO27475.1 - 0.01 15.6 0.0 2 8.1 0.0 2.6 1 1 1 2 2 2 0 Dimerisation domain of Ca+-activated chloride-channel, anoctamin RsgA_GTPase PF03193.16 KOO27475.1 - 0.014 15.3 0.3 4.8 7.1 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase HDA2-3 PF11496.8 KOO27475.1 - 0.014 14.6 0.0 0.031 13.5 0.0 1.5 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 AAA_30 PF13604.6 KOO27475.1 - 0.016 15.0 0.1 0.74 9.5 0.1 3.2 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 KOO27475.1 - 0.022 15.3 3.7 0.088 13.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain GTP_EFTU PF00009.27 KOO27475.1 - 0.026 14.1 2.8 0.15 11.6 2.6 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF1654 PF07867.11 KOO27475.1 - 0.034 13.9 0.2 0.098 12.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1654) TsaE PF02367.17 KOO27475.1 - 0.12 12.4 3.5 0.61 10.1 0.1 3.3 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE zf-C2HC_2 PF13913.6 KOO27476.1 - 1.4e-22 79.1 16.3 1.3e-08 34.5 1.1 3.4 3 0 0 3 3 3 3 zinc-finger of a C2HC-type SHOCT PF09851.9 KOO27476.1 - 5.4e-06 26.0 0.3 1.2e-05 24.9 0.3 1.6 1 0 0 1 1 1 1 Short C-terminal domain zf-C2H2 PF00096.26 KOO27476.1 - 2.1e-05 24.7 8.1 0.0044 17.4 0.2 3.6 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-RING_7 PF02591.15 KOO27476.1 - 5.6e-05 23.2 4.0 1.1 9.6 0.0 4.3 4 0 0 4 4 4 2 C4-type zinc ribbon domain zf-C2H2_4 PF13894.6 KOO27476.1 - 0.00088 19.9 20.8 0.0031 18.2 1.2 3.8 4 0 0 4 4 3 1 C2H2-type zinc finger Rad50_zn_hook PF04423.14 KOO27476.1 - 0.001 18.8 1.2 0.73 9.7 0.0 3.4 3 0 0 3 3 3 1 Rad50 zinc hook motif zf-C2H2_jaz PF12171.8 KOO27476.1 - 0.0054 17.0 5.6 2.4 8.6 0.0 4.0 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.6 KOO27476.1 - 0.01 16.1 5.2 5.1 7.4 0.0 3.8 4 0 0 4 4 4 2 zinc-ribbon PADR1 PF08063.12 KOO27476.1 - 0.032 14.0 0.9 30 4.5 0.1 3.4 3 0 0 3 3 3 0 PADR1 (NUC008) domain Zn_Tnp_IS1595 PF12760.7 KOO27476.1 - 0.041 13.8 1.8 6.8 6.7 0.1 2.9 2 0 0 2 2 2 0 Transposase zinc-ribbon domain GvpG PF05120.12 KOO27476.1 - 0.06 13.4 0.5 0.14 12.1 0.5 1.6 1 0 0 1 1 1 0 Gas vesicle protein G zf_UBZ PF18439.1 KOO27476.1 - 0.1 12.2 2.1 4.2 7.1 0.1 3.0 3 0 0 3 3 2 0 Ubiquitin-Binding Zinc Finger DUF2318 PF10080.9 KOO27476.1 - 0.12 12.5 0.9 3.9 7.6 0.0 3.2 4 0 0 4 4 4 0 Predicted membrane protein (DUF2318) DUF5423 PF17461.2 KOO27476.1 - 0.18 10.6 1.2 0.24 10.2 1.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5423) DUF2256 PF10013.9 KOO27476.1 - 0.31 11.2 6.1 15 5.8 0.0 3.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Lar_restr_allev PF14354.6 KOO27476.1 - 0.36 11.2 9.1 2.1 8.8 0.1 4.1 4 0 0 4 4 4 0 Restriction alleviation protein Lar FYVE PF01363.21 KOO27476.1 - 0.41 10.8 5.6 11 6.2 0.5 3.7 4 0 0 4 4 4 0 FYVE zinc finger TRAF6_Z2 PF18048.1 KOO27476.1 - 0.5 10.5 8.2 0.57 10.3 0.2 3.1 3 0 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 Zn-ribbon_8 PF09723.10 KOO27476.1 - 0.82 9.8 7.9 7 6.9 0.1 3.9 4 0 0 4 4 3 0 Zinc ribbon domain zf-FPG_IleRS PF06827.14 KOO27476.1 - 3.2 7.7 9.3 1.2 9.0 0.4 2.7 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-Di19 PF05605.12 KOO27476.1 - 3.7 7.9 11.5 7.3 7.0 0.7 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding FixQ PF05545.11 KOO27477.1 - 0.0024 17.8 0.4 0.0065 16.4 0.4 1.7 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ UQ_con PF00179.26 KOO27478.1 - 1.7e-52 176.8 0.0 1.9e-52 176.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOO27478.1 - 0.0024 18.2 0.1 0.0028 17.9 0.1 1.4 1 1 0 1 1 1 1 RWD domain Golgin_A5 PF09787.9 KOO27479.1 - 1.5 8.2 82.5 1.4 8.4 5.6 6.0 2 1 2 5 5 5 0 Golgin subfamily A member 5 DUF2103 PF09876.9 KOO27481.1 - 6e-05 23.0 0.3 0.001 19.0 0.3 2.5 1 1 0 1 1 1 1 Predicted metal-binding protein (DUF2103) Not3 PF04065.15 KOO27481.1 - 0.003 17.0 3.7 0.0056 16.2 0.0 3.0 3 1 0 3 3 3 1 Not1 N-terminal domain, CCR4-Not complex component PARP PF00644.20 KOO27482.1 - 5.3e-11 42.5 0.0 9.9e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Cation_efflux PF01545.21 KOO27483.1 - 6e-09 35.9 1.2 1.3e-08 34.8 1.2 1.7 1 1 0 1 1 1 1 Cation efflux family zf-RING_UBOX PF13445.6 KOO27484.1 - 1.6e-10 40.8 1.5 2.3e-10 40.3 0.7 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOO27484.1 - 3.9e-09 36.2 3.2 8e-09 35.2 3.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO27484.1 - 6.5e-09 35.6 3.2 1.2e-08 34.8 3.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOO27484.1 - 1.1e-08 34.8 3.4 2.2e-08 33.8 3.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO27484.1 - 2.2e-08 34.3 4.2 4.8e-08 33.2 4.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO27484.1 - 2.4e-08 33.7 5.2 7e-08 32.2 5.2 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Sulf_transp PF04143.14 KOO27484.1 - 6.1e-07 29.3 9.9 1.5e-06 28.0 9.9 1.6 1 1 0 1 1 1 1 Sulphur transport Prok-RING_4 PF14447.6 KOO27484.1 - 0.00022 21.0 5.0 0.00085 19.1 5.1 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KOO27484.1 - 0.00034 20.7 5.4 0.0008 19.5 5.4 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 KOO27484.1 - 0.001 18.8 3.9 0.0021 17.8 3.9 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KOO27484.1 - 0.03 14.6 2.0 0.075 13.3 2.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Rad50_zn_hook PF04423.14 KOO27484.1 - 0.094 12.6 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-RING_11 PF17123.5 KOO27484.1 - 0.22 11.3 4.4 0.23 11.2 2.8 2.0 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_5 PF17121.5 KOO27484.1 - 0.84 9.6 5.4 1.2 9.1 3.2 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn-C2H2_12 PF18112.1 KOO27484.1 - 1.1 9.8 3.3 49 4.5 0.0 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain LPP PF04728.13 KOO27485.1 - 0.44 11.0 0.3 0.44 11.0 0.3 1.8 2 0 0 2 2 2 0 Lipoprotein leucine-zipper HET-S PF17108.5 KOO27485.1 - 1.6 8.6 8.4 20 5.0 0.3 3.1 3 0 0 3 3 3 0 N-terminal small S protein of HET, non-prionic Arm PF00514.23 KOO27486.1 - 1.8e-48 161.2 19.2 9.8e-09 35.0 0.2 8.1 8 0 0 8 8 8 7 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO27486.1 - 1.5e-07 31.3 9.0 0.025 14.6 0.2 4.9 2 1 3 5 5 5 3 Spinocerebellar ataxia type 10 protein domain TPR_11 PF13414.6 KOO27486.1 - 0.00027 20.5 0.2 1.3 8.8 0.0 3.4 3 0 0 3 3 3 2 TPR repeat HEAT_EZ PF13513.6 KOO27486.1 - 0.00058 20.3 16.8 0.16 12.5 0.2 5.3 5 0 0 5 5 5 2 HEAT-like repeat Arm_2 PF04826.13 KOO27486.1 - 0.00084 18.9 1.1 0.0078 15.7 0.1 2.2 1 1 0 2 2 2 1 Armadillo-like CRS1_YhbY PF01985.21 KOO27486.1 - 0.0014 18.7 0.3 1.9 8.7 0.0 4.6 6 0 0 6 6 6 1 CRS1 / YhbY (CRM) domain TPR_17 PF13431.6 KOO27486.1 - 0.0053 17.0 0.1 46 4.7 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27486.1 - 0.019 15.1 7.8 1 9.7 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO27486.1 - 0.019 15.7 2.9 0.019 15.7 2.9 6.7 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27486.1 - 0.022 15.0 0.2 2.1 8.8 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat PX PF00787.24 KOO27486.1 - 0.08 12.9 0.2 0.16 11.9 0.2 1.5 1 0 0 1 1 1 0 PX domain Phosphoesterase PF04185.14 KOO27487.1 - 2e-50 172.0 0.0 3.5e-28 98.8 0.0 2.3 1 1 1 2 2 2 2 Phosphoesterase family Got1 PF04178.12 KOO27488.1 - 7.1e-31 107.0 14.2 9.6e-31 106.5 14.2 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2157 PF09925.9 KOO27488.1 - 0.19 11.5 9.7 0.64 9.8 9.9 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) Kinesin PF00225.23 KOO27489.1 - 0.00042 19.4 0.0 0.0006 18.8 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain FHA PF00498.26 KOO27489.1 - 0.017 15.4 0.0 0.03 14.7 0.0 1.4 1 0 0 1 1 1 0 FHA domain HHH_3 PF12836.7 KOO27491.1 - 5.3e-12 45.8 0.0 8.7e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_9 PF17674.1 KOO27491.1 - 9.7e-09 36.0 0.0 2.5e-08 34.7 0.0 1.7 1 1 0 1 1 1 1 HHH domain S1 PF00575.23 KOO27491.1 - 1.4e-08 35.0 0.0 2e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain T2SSK PF03934.13 KOO27491.1 - 0.016 14.6 0.2 0.8 9.0 0.0 2.1 1 1 0 2 2 2 0 Type II secretion system (T2SS), protein K HHH PF00633.23 KOO27491.1 - 0.017 15.0 0.0 0.054 13.4 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif TPR_12 PF13424.6 KOO27492.1 - 4.1e-73 241.7 33.7 5.5e-18 65.0 1.1 5.6 1 1 5 6 6 6 5 Tetratricopeptide repeat Ank_2 PF12796.7 KOO27492.1 - 9.1e-68 224.9 12.5 7.3e-13 48.9 0.5 6.8 2 1 8 10 10 9 9 Ankyrin repeats (3 copies) TPR_10 PF13374.6 KOO27492.1 - 1.6e-62 205.8 19.6 1.4e-12 47.0 0.3 7.4 6 0 0 6 6 6 6 Tetratricopeptide repeat Ank_4 PF13637.6 KOO27492.1 - 5.8e-49 163.9 2.1 1.3e-07 32.0 0.0 10.5 5 4 4 10 10 10 9 Ankyrin repeats (many copies) Tex_N PF09371.10 KOO27492.1 - 2e-34 118.8 0.0 4.6e-34 117.7 0.0 1.6 1 0 0 1 1 1 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 KOO27492.1 - 4.1e-32 111.3 0.6 7.6e-32 110.4 0.6 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain Ank_5 PF13857.6 KOO27492.1 - 2.4e-31 107.4 9.4 8.8e-05 22.7 0.1 10.3 5 3 6 11 11 11 6 Ankyrin repeats (many copies) Ank PF00023.30 KOO27492.1 - 3.4e-28 96.8 14.4 0.015 15.7 0.0 13.2 14 0 0 14 14 13 7 Ankyrin repeat Ank_3 PF13606.6 KOO27492.1 - 3.4e-27 91.5 8.9 0.0088 16.5 0.0 14.1 14 0 0 14 14 14 2 Ankyrin repeat TPR_1 PF00515.28 KOO27492.1 - 8.9e-21 72.8 2.2 0.0039 16.9 0.1 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO27492.1 - 2.9e-17 63.0 10.7 2e-11 43.9 1.4 3.3 2 1 1 3 3 3 2 MalT-like TPR region TPR_8 PF13181.6 KOO27492.1 - 7.2e-17 60.1 1.8 0.016 15.4 0.0 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27492.1 - 9.1e-14 50.4 4.9 0.082 13.1 0.1 7.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO27492.1 - 1.2e-12 46.9 15.7 0.047 13.7 0.1 7.4 7 0 0 7 7 6 4 Tetratricopeptide repeat PARP PF00644.20 KOO27492.1 - 2.4e-07 30.6 0.0 4.7e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain TPR_17 PF13431.6 KOO27492.1 - 7.9e-07 29.0 5.5 5.5 7.6 0.0 6.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27492.1 - 1.6e-05 25.5 30.5 0.014 16.0 1.1 8.2 6 3 1 7 7 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO27492.1 - 0.00019 21.9 13.0 0.029 14.9 1.7 4.4 1 1 2 4 4 4 3 Tetratricopeptide repeat TPR_4 PF07721.14 KOO27492.1 - 0.00042 20.7 42.0 0.43 11.3 0.0 10.3 11 0 0 11 11 7 2 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO27492.1 - 0.0044 17.3 20.1 8.7 6.7 0.1 7.4 8 0 0 8 8 7 0 Osmosensory transporter coiled coil DUF460 PF04312.13 KOO27492.1 - 0.066 12.9 0.1 0.18 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF460) YqgF PF14639.6 KOO27492.1 - 0.14 11.9 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 Thioredoxin PF00085.20 KOO27493.1 - 3.8e-27 94.3 0.3 5.8e-26 90.5 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.13 KOO27493.1 - 0.00048 19.6 0.0 0.01 15.2 0.0 2.0 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KOO27493.1 - 0.0026 18.2 0.4 0.0071 16.8 0.1 1.9 2 1 0 2 2 2 1 Thioredoxin-like domain Sipho_Gp157 PF05565.11 KOO27493.1 - 0.031 14.3 1.9 0.055 13.5 1.9 1.5 1 0 0 1 1 1 0 Siphovirus Gp157 AhpC-TSA PF00578.21 KOO27493.1 - 0.031 14.2 0.0 0.081 12.9 0.0 1.7 1 0 0 1 1 1 0 AhpC/TSA family TMF_DNA_bd PF12329.8 KOO27493.1 - 0.053 13.5 3.8 0.1 12.6 3.8 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Thioredoxin_7 PF13899.6 KOO27493.1 - 0.06 13.5 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like OmpH PF03938.14 KOO27493.1 - 0.1 13.0 5.6 0.12 12.7 4.4 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) SASP PF00269.20 KOO27493.1 - 0.14 12.2 0.7 0.41 10.7 0.5 1.9 2 0 0 2 2 2 0 Small, acid-soluble spore proteins, alpha/beta type FAD_binding_3 PF01494.19 KOO27494.1 - 2.2e-17 63.3 0.6 5.4e-11 42.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 KOO27494.1 - 9.4e-06 25.4 8.1 9.7e-05 22.1 1.9 2.7 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOO27494.1 - 1e-05 25.6 0.9 2.6e-05 24.4 0.9 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOO27494.1 - 6.3e-05 22.4 2.3 0.0084 15.4 0.3 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO27494.1 - 0.01 14.9 0.3 0.019 14.0 0.3 1.5 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 KOO27494.1 - 0.024 13.5 0.1 0.54 9.1 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.27 KOO27494.1 - 0.027 15.0 1.6 14 6.3 0.6 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 KOO27494.1 - 0.075 11.8 0.1 0.1 11.4 0.1 1.1 1 0 0 1 1 1 0 MCRA family SE PF08491.10 KOO27494.1 - 0.095 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Squalene epoxidase NAD_binding_9 PF13454.6 KOO27494.1 - 0.15 12.0 9.0 0.1 12.6 2.0 2.9 2 1 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 KOO27494.1 - 0.63 9.0 4.2 9.4 5.2 4.2 2.2 1 1 0 1 1 1 0 Lycopene cyclase protein Methyltransf_21 PF05050.12 KOO27495.1 - 1.2e-05 25.4 0.0 2.1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain SRR1 PF07985.12 KOO27498.1 - 1e-09 38.3 0.4 1.4e-07 31.4 0.2 2.4 2 0 0 2 2 2 2 SRR1 NAD_binding_1 PF00175.21 KOO27500.1 - 1.8e-21 76.8 0.0 1e-19 71.2 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOO27500.1 - 2.9e-11 43.6 0.0 5e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KOO27500.1 - 6.4e-05 23.1 0.0 0.007 16.5 0.0 2.1 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Complex1_30kDa PF00329.19 KOO27501.1 - 3.1e-44 150.5 0.0 4.1e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit CLP_protease PF00574.23 KOO27502.1 - 3e-78 261.9 0.1 3.6e-78 261.6 0.1 1.0 1 0 0 1 1 1 1 Clp protease CorA PF01544.18 KOO27503.1 - 0.0094 15.3 1.2 0.052 12.8 0.1 2.2 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Glucosamine_iso PF01182.20 KOO27504.1 - 3.8e-31 108.7 0.0 5.2e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Hydrolase_6 PF13344.6 KOO27505.1 - 1.1e-09 38.3 0.0 3.9e-09 36.5 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Dak1 PF02733.17 KOO27506.1 - 2.3e-108 361.8 4.7 2.3e-108 361.8 4.7 1.6 2 0 0 2 2 2 1 Dak1 domain Dak2 PF02734.17 KOO27506.1 - 9e-42 142.9 14.3 9e-42 142.9 14.3 2.2 3 0 0 3 3 3 1 DAK2 domain Methyltr_RsmB-F PF01189.17 KOO27507.1 - 6.7e-42 143.4 0.0 9.5e-42 142.9 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 KOO27507.1 - 1.9e-06 27.8 0.0 3.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO27507.1 - 9.2e-05 23.1 0.5 0.0041 17.8 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO27507.1 - 0.0002 20.8 0.0 0.0016 17.8 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 KOO27507.1 - 0.00072 19.1 0.0 0.0023 17.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 KOO27507.1 - 0.00086 19.5 0.0 0.0014 18.7 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmF_N PF17125.5 KOO27507.1 - 0.0011 19.4 0.0 0.0021 18.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltransf_3 PF01596.17 KOO27507.1 - 0.013 14.7 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase DUF2431 PF10354.9 KOO27507.1 - 0.06 13.6 0.0 0.094 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Methyltransf_11 PF08241.12 KOO27507.1 - 0.16 12.6 0.2 3 8.5 0.2 2.6 2 1 0 2 2 2 0 Methyltransferase domain EF-hand_1 PF00036.32 KOO27508.1 - 4e-19 66.7 19.6 7.8e-05 22.0 0.1 7.1 7 0 0 7 7 7 6 EF hand EF-hand_6 PF13405.6 KOO27508.1 - 5.6e-17 60.2 20.8 0.0029 17.4 0.2 7.7 8 0 0 8 8 8 6 EF-hand domain EF-hand_7 PF13499.6 KOO27508.1 - 7.8e-17 61.5 18.2 2.7e-05 24.5 2.6 5.3 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO27508.1 - 5e-09 35.9 8.6 4.3e-08 32.9 0.4 4.6 3 2 2 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO27508.1 - 6e-08 31.8 13.2 0.00054 19.3 0.0 5.3 6 0 0 6 6 6 2 EF hand Dockerin_1 PF00404.18 KOO27508.1 - 0.11 12.7 0.8 6.8 7.0 0.2 3.0 2 1 0 2 2 2 0 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KOO27508.1 - 0.14 12.5 5.5 1.3 9.4 0.3 3.8 4 1 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO27508.1 - 0.28 11.1 4.0 16 5.4 0.0 4.1 4 2 1 5 5 5 0 Caleosin related protein ELFV_dehydrog_N PF02812.18 KOO27509.1 - 0.027 14.3 0.3 0.22 11.4 0.0 2.4 3 0 0 3 3 3 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain GSH-S_ATP PF02955.16 KOO27509.1 - 0.2 11.0 0.0 0.39 10.1 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain Cpn60_TCP1 PF00118.24 KOO27510.1 - 5.9e-75 252.8 10.2 1.4e-45 155.8 3.5 2.4 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family Kinesin PF00225.23 KOO27512.1 - 1.1e-61 208.7 0.0 2.3e-61 207.5 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain CUE PF02845.16 KOO27512.1 - 0.0092 15.7 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 CUE domain Microtub_bd PF16796.5 KOO27512.1 - 0.052 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Microtubule binding JmjC PF02373.22 KOO27513.1 - 1.3e-33 115.8 0.1 2.3e-33 115.0 0.1 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 KOO27513.1 - 8.3e-14 51.3 0.2 1.7e-13 50.3 0.2 1.6 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 KOO27513.1 - 2.6e-11 43.2 7.5 4.8e-11 42.4 7.5 1.5 1 0 0 1 1 1 1 PHD-finger ARID PF01388.21 KOO27513.1 - 1.4e-07 32.0 0.0 2.7e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PHD_2 PF13831.6 KOO27513.1 - 0.036 13.6 2.8 0.09 12.3 2.8 1.7 1 0 0 1 1 1 0 PHD-finger Med3 PF11593.8 KOO27513.1 - 3 6.9 8.6 4.9 6.2 8.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-RING_2 PF13639.6 KOO27513.1 - 4.7 7.6 8.8 36 4.8 9.0 2.3 1 1 1 2 2 2 0 Ring finger domain Costars PF14705.6 KOO27515.1 - 4.6e-06 26.7 0.1 5.5e-06 26.5 0.1 1.1 1 0 0 1 1 1 1 Costars RhoGEF PF00621.20 KOO27517.1 - 1.8e-35 122.8 0.0 2.2e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 RhoGEF domain Kinesin PF00225.23 KOO27518.1 - 8e-98 327.4 0.0 1.1e-97 327.0 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO27518.1 - 1.4e-22 80.3 0.0 5.2e-22 78.4 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding YabA PF06156.13 KOO27518.1 - 0.28 11.8 2.3 1.8 9.3 1.0 2.8 2 0 0 2 2 2 0 Initiation control protein YabA DUF1640 PF07798.11 KOO27518.1 - 0.6 10.1 0.0 0.6 10.1 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) JAKMIP_CC3 PF16034.5 KOO27518.1 - 4.3 7.2 12.9 35 4.3 0.0 2.5 2 1 0 2 2 2 0 JAKMIP CC3 domain HALZ PF02183.18 KOO27518.1 - 9.3 6.6 8.3 49 4.3 3.9 3.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper KIAA1430 PF13879.6 KOO27520.1 - 0.00033 21.4 7.2 0.00033 21.4 7.2 3.6 3 2 0 3 3 3 1 KIAA1430 homologue Methyltr_RsmB-F PF01189.17 KOO27521.1 - 1.7e-15 57.2 0.0 2.1e-15 56.9 0.0 1.0 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_11 PF08241.12 KOO27521.1 - 0.19 12.4 0.0 0.37 11.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain AMIN PF11741.8 KOO27522.1 - 0.1 12.8 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 AMIN domain DUF4986 PF16375.5 KOO27522.1 - 0.19 12.4 2.3 0.61 10.8 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function GST_N PF02798.20 KOO27524.1 - 2.7e-13 50.0 0.0 4.4e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOO27524.1 - 3e-10 40.2 0.0 4.9e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KOO27524.1 - 6.1e-07 29.7 0.0 1.2e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 KOO27524.1 - 1.2e-06 28.8 0.0 2.2e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO27524.1 - 1e-05 25.4 0.1 1.7e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOO27524.1 - 1.5e-05 25.1 0.0 2.5e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain polyprenyl_synt PF00348.17 KOO27525.1 - 1.5e-75 253.6 0.7 1.8e-75 253.3 0.7 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase SQS_PSY PF00494.19 KOO27525.1 - 0.0099 15.4 5.9 0.015 14.8 5.6 1.5 1 1 0 1 1 1 1 Squalene/phytoene synthase Glu-tRNAGln PF02686.15 KOO27527.1 - 0.29 11.5 1.4 10 6.5 0.2 2.7 3 0 0 3 3 3 0 Glu-tRNAGln amidotransferase C subunit DUF2120 PF09893.9 KOO27527.1 - 0.34 11.0 1.6 4.3 7.4 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) DUF5340 PF17275.2 KOO27527.1 - 2.5 8.3 5.0 23 5.2 0.1 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5340) SH3BP5 PF05276.14 KOO27527.1 - 6.1 6.6 26.2 1 9.1 1.1 2.9 1 1 1 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) SRP_TPR_like PF17004.5 KOO27528.1 - 4.6e-13 49.2 0.0 2.2e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 Putative TPR-like repeat SRP72 PF08492.12 KOO27528.1 - 8.9e-12 45.3 9.5 2.1e-11 44.1 9.5 1.6 1 0 0 1 1 1 1 SRP72 RNA-binding domain TPR_14 PF13428.6 KOO27528.1 - 6e-09 36.0 35.9 0.089 13.7 0.1 8.1 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO27528.1 - 6.1e-07 29.0 8.3 0.98 9.6 0.1 5.9 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO27528.1 - 2.7e-06 27.5 15.4 0.2 11.9 0.1 5.6 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 KOO27528.1 - 4.4e-05 23.3 30.8 0.11 12.6 0.5 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27528.1 - 5.9e-05 23.0 9.0 0.027 14.6 0.1 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO27528.1 - 0.00098 19.6 0.2 0.00098 19.6 0.2 7.6 7 2 1 8 8 8 2 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 KOO27528.1 - 0.0038 17.7 0.4 0.55 10.7 0.1 2.9 2 0 0 2 2 2 1 Alkyl sulfatase dimerisation TPR_12 PF13424.6 KOO27528.1 - 0.025 14.9 34.1 0.24 11.7 4.2 7.1 7 1 0 7 7 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO27528.1 - 0.039 14.0 0.5 7.7 6.7 0.0 3.9 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 KOO27528.1 - 0.24 12.1 52.1 0.85 10.3 2.9 8.4 7 2 2 9 9 7 0 Tetratricopeptide repeat SPO22 PF08631.10 KOO27528.1 - 0.32 10.4 4.4 3.2 7.2 0.1 3.0 2 1 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like TPR_10 PF13374.6 KOO27528.1 - 1.5 8.8 9.2 3.2 7.8 0.8 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO27528.1 - 1.9 8.7 30.6 5.8 7.1 0.1 6.9 6 1 2 8 8 8 0 Tetratricopeptide repeat FAD_binding_4 PF01565.23 KOO27531.1 - 1.1e-23 83.6 0.5 1.7e-23 82.9 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 KOO27531.1 - 1.3e-14 54.7 0.0 4.7e-14 52.8 0.0 1.8 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase DUF2462 PF09495.10 KOO27532.1 - 1.6e-08 35.1 7.1 2.4e-08 34.6 7.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) zf-CCCH PF00642.24 KOO27533.1 - 3.2e-07 30.1 1.2 6.5e-07 29.1 1.2 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KOO27533.1 - 5.5e-06 26.0 2.7 1.1e-05 25.1 2.7 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOO27533.1 - 7.4e-06 25.8 5.1 1.7e-05 24.7 5.1 1.6 1 0 0 1 1 1 1 Zinc finger domain GCV_H PF01597.19 KOO27533.1 - 0.02 14.8 0.0 0.046 13.6 0.0 1.7 2 0 0 2 2 2 0 Glycine cleavage H-protein zf-CCCH_2 PF14608.6 KOO27533.1 - 0.04 14.4 3.4 0.08 13.4 3.4 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF2171 PF09939.9 KOO27533.1 - 0.045 14.0 0.2 0.39 11.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2171) Longin PF13774.6 KOO27534.1 - 8.7e-23 80.2 0.0 1.4e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 KOO27534.1 - 6.5e-17 61.1 0.0 1.1e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Synaptobrevin Bacteroid_pep PF14406.6 KOO27534.1 - 0.074 13.4 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Bacteroidetes BBS2_C PF14782.6 KOO27534.1 - 0.22 10.2 0.8 0.41 9.4 0.8 1.4 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal PhoD PF09423.10 KOO27535.1 - 2.8e-12 46.3 0.0 4.7e-11 42.3 0.0 2.6 1 1 0 1 1 1 1 PhoD-like phosphatase Pkinase PF00069.25 KOO27536.1 - 3.7e-28 98.6 0.0 4.5e-28 98.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27536.1 - 1.4e-17 63.9 0.0 1.7e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO27536.1 - 0.00036 19.9 0.0 0.0005 19.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KOO27536.1 - 0.012 14.7 0.1 0.014 14.4 0.1 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 KOO27536.1 - 0.028 13.2 0.0 0.031 13.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 KOO27536.1 - 0.083 12.2 0.0 0.094 12.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like EF-hand_7 PF13499.6 KOO27538.1 - 2.1e-21 76.2 1.7 1.5e-10 41.4 0.0 2.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO27538.1 - 2.5e-15 54.8 1.0 0.0012 18.2 0.0 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO27538.1 - 3.3e-14 51.5 2.0 0.00031 20.4 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KOO27538.1 - 5.5e-11 42.1 0.2 0.00061 19.6 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO27538.1 - 1.4e-08 33.9 1.0 0.0012 18.2 0.0 3.5 3 0 0 3 3 3 2 EF hand DUF5580 PF17743.1 KOO27538.1 - 0.021 13.4 0.0 0.027 13.0 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EF-hand_10 PF14788.6 KOO27538.1 - 0.044 13.6 0.1 7 6.6 0.0 2.8 3 0 0 3 3 3 0 EF hand APH PF01636.23 KOO27538.1 - 0.058 13.3 1.5 0.11 12.4 1.5 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Stm1_N PF09598.10 KOO27538.1 - 4.1 8.3 7.1 70 4.4 0.0 2.8 2 0 0 2 2 2 0 Stm1 Fapy_DNA_glyco PF01149.24 KOO27539.1 - 6.4e-30 104.2 0.0 1.2e-29 103.3 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 KOO27539.1 - 2.1e-20 72.5 0.0 3.5e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain FbpA PF05833.11 KOO27539.1 - 0.011 14.6 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Ribosomal_S13 PF00416.22 KOO27539.1 - 0.087 13.2 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S13/S18 CBM_6 PF03422.15 KOO27540.1 - 0.013 15.8 0.2 0.03 14.6 0.2 1.7 1 0 0 1 1 1 0 Carbohydrate binding module (family 6) PPC PF04151.15 KOO27540.1 - 0.089 13.9 3.6 4.6 8.4 0.0 2.9 2 1 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain DEAD PF00270.29 KOO27541.1 - 3.9e-15 56.1 0.0 4.7e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO27541.1 - 0.0035 17.4 0.0 0.0047 16.9 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Pkinase PF00069.25 KOO27543.1 - 3.9e-62 210.0 0.0 5.1e-62 209.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27543.1 - 4e-40 137.7 0.0 6.3e-40 137.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Thioredoxin PF00085.20 KOO27543.1 - 2.2e-24 85.4 0.1 3.5e-24 84.8 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin APH PF01636.23 KOO27543.1 - 2.2e-05 24.5 6.4 0.0024 17.9 1.8 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Thioredoxin_7 PF13899.6 KOO27543.1 - 2.4e-05 24.4 0.2 5.1e-05 23.4 0.2 1.6 1 0 0 1 1 1 1 Thioredoxin-like Pkinase_fungal PF17667.1 KOO27543.1 - 5.5e-05 22.1 0.0 0.0037 16.1 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KOO27543.1 - 0.00035 20.0 0.2 0.00071 19.0 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family OST3_OST6 PF04756.13 KOO27543.1 - 0.0024 17.3 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Kinase-like PF14531.6 KOO27543.1 - 0.0058 16.0 0.4 0.025 13.9 0.4 1.9 1 1 0 1 1 1 1 Kinase-like Thioredoxin_8 PF13905.6 KOO27543.1 - 0.018 15.4 0.0 0.035 14.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_2 PF13098.6 KOO27543.1 - 0.03 14.8 0.1 0.13 12.7 0.1 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KOO27543.1 - 0.04 13.7 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin AhpC-TSA PF00578.21 KOO27543.1 - 0.094 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family YAcAr PF10686.9 KOO27545.1 - 0.057 13.4 1.0 0.25 11.3 0.3 2.4 2 0 0 2 2 2 0 YspA, cpYpsA-related SLOG family Myosin_head PF00063.21 KOO27546.1 - 1.3e-143 479.7 0.0 1e-83 281.8 0.0 2.6 2 1 0 2 2 2 2 Myosin head (motor domain) AAA_22 PF13401.6 KOO27546.1 - 0.0021 18.4 0.1 0.34 11.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain EF-hand_7 PF13499.6 KOO27546.1 - 0.0037 17.7 0.0 0.047 14.1 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO27546.1 - 0.0056 16.1 0.0 3.8 7.3 0.0 2.6 2 0 0 2 2 2 2 EF hand AAA_16 PF13191.6 KOO27546.1 - 0.029 14.8 2.4 0.07 13.5 0.1 2.8 3 0 0 3 3 3 0 AAA ATPase domain EF-hand_6 PF13405.6 KOO27546.1 - 0.035 14.0 0.0 16 5.8 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain WW PF00397.26 KOO27546.1 - 0.043 13.9 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 WW domain PAS PF00989.25 KOO27547.1 - 3.3e-12 46.4 0.0 1e-11 44.8 0.0 1.9 1 1 0 1 1 1 1 PAS fold PAS_4 PF08448.10 KOO27547.1 - 2.6e-06 27.7 0.4 1.5e-05 25.2 0.0 2.3 2 1 1 3 3 3 1 PAS fold PAS_9 PF13426.7 KOO27547.1 - 8.7e-05 22.7 0.0 0.00018 21.7 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 KOO27547.1 - 0.019 15.0 0.0 0.064 13.3 0.0 1.9 1 0 0 1 1 1 0 PAS domain SlyX PF04102.12 KOO27547.1 - 0.13 12.9 0.2 0.13 12.9 0.2 2.6 3 0 0 3 3 3 0 SlyX HIP1_clath_bdg PF16515.5 KOO27547.1 - 0.25 12.0 5.5 2.5 8.7 0.1 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cep57_CLD_2 PF14197.6 KOO27547.1 - 0.87 9.7 7.4 4.6 7.4 0.5 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Orai-1 PF07856.12 KOO27549.1 - 0.084 12.6 6.6 0.43 10.2 6.6 2.1 1 1 0 1 1 1 0 Mediator of CRAC channel activity NifU_N PF01592.16 KOO27550.1 - 4.6e-51 172.3 0.0 5.3e-51 172.1 0.0 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain SLATT_1 PF18181.1 KOO27551.1 - 1.3e-20 73.6 2.2 4.7e-20 71.7 2.2 2.1 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain 1 DUF4231 PF14015.6 KOO27551.1 - 3.3e-09 37.2 6.9 2.3e-08 34.5 0.2 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF4231) SLATT_3 PF18184.1 KOO27551.1 - 0.085 13.0 1.6 0.13 12.4 0.1 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 IQ PF00612.27 KOO27552.1 - 4e-07 29.2 0.3 0.038 13.8 0.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif PH PF00169.29 KOO27552.1 - 0.03 14.8 0.0 0.063 13.8 0.0 1.5 1 0 0 1 1 1 0 PH domain MatE PF01554.18 KOO27554.1 - 1.8e-22 79.7 17.3 3e-14 53.0 1.7 4.5 5 0 0 5 5 5 2 MatE Hydrolase_4 PF12146.8 KOO27554.1 - 4.5e-06 26.1 0.6 0.00016 21.1 0.0 2.9 3 1 0 3 3 3 1 Serine aminopeptidase, S33 Mid2 PF04478.12 KOO27554.1 - 0.0011 18.8 0.2 0.0022 17.9 0.2 1.4 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Abhydrolase_1 PF00561.20 KOO27554.1 - 0.047 13.3 0.0 0.26 10.9 0.0 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold SKG6 PF08693.10 KOO27554.1 - 0.79 9.2 13.7 0.012 15.0 4.8 2.8 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Ser_hydrolase PF06821.13 KOO27554.1 - 3 7.7 6.1 1.2e+02 2.4 2.0 3.5 3 0 0 3 3 3 0 Serine hydrolase Ank_2 PF12796.7 KOO27555.1 - 2.1e-06 28.2 0.1 6.5e-06 26.6 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO27555.1 - 3.6e-05 23.8 2.2 0.0098 16.3 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 KOO27555.1 - 8.1e-05 22.8 0.7 0.0011 19.2 0.5 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO27555.1 - 0.00024 21.6 1.3 0.89 10.2 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO27555.1 - 0.00097 19.5 3.6 0.25 11.9 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat KIAA1430 PF13879.6 KOO27556.1 - 0.0024 18.6 0.7 0.0024 18.6 0.7 4.8 1 1 2 4 4 4 2 KIAA1430 homologue bZIP_1 PF00170.21 KOO27556.1 - 0.019 15.0 5.4 0.019 15.0 5.4 5.7 6 1 1 7 7 7 0 bZIP transcription factor ACPS PF01648.20 KOO27556.1 - 0.23 11.6 3.5 0.29 11.3 0.9 2.5 1 1 1 2 2 2 0 4'-phosphopantetheinyl transferase superfamily TPH PF13868.6 KOO27557.1 - 0.048 12.2 23.1 0.063 11.8 23.1 1.1 1 0 0 1 1 1 0 Trichohyalin-plectin-homology domain DUF2180 PF09947.9 KOO27557.1 - 0.14 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) Dam PF05869.11 KOO27559.1 - 0.046 13.3 0.0 0.057 13.0 0.0 1.1 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) PALP PF00291.25 KOO27560.1 - 1.1e-64 218.7 0.1 1.8e-64 218.0 0.1 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 KOO27560.1 - 6.7e-10 39.3 0.3 5.4e-09 36.4 0.3 2.4 2 1 0 2 2 2 1 CBS domain Golgin_A5 PF09787.9 KOO27561.1 - 2.3 7.6 15.7 2.6 7.4 9.0 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 GST_N_3 PF13417.6 KOO27562.1 - 9.6e-08 32.3 0.0 1.9e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO27562.1 - 1.3e-07 31.8 0.0 2.2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO27562.1 - 0.0015 18.5 0.7 0.0038 17.2 0.7 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOO27562.1 - 0.12 12.7 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Pkinase PF00069.25 KOO27563.1 - 3.4e-42 144.6 0.0 1.7e-41 142.3 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27563.1 - 1.4e-16 60.6 0.0 1.9e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 KOO27564.1 - 1.6e-12 47.3 0.6 2.2e-05 24.4 0.0 4.1 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain Raf1_N PF18578.1 KOO27564.1 - 0.12 12.9 0.5 0.28 11.7 0.5 1.5 1 0 0 1 1 1 0 Rubisco accumulation factor 1 alpha helical domain EF-hand_7 PF13499.6 KOO27565.1 - 1.5e-08 35.0 0.2 3.9e-08 33.6 0.2 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO27565.1 - 8.8e-08 31.2 0.1 0.00097 18.5 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO27565.1 - 1.8e-06 27.4 0.2 0.0036 17.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO27565.1 - 4.7e-06 26.3 1.0 0.021 14.6 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_10 PF14788.6 KOO27565.1 - 0.0012 18.7 1.5 0.013 15.4 0.1 2.4 1 1 1 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO27565.1 - 0.042 14.2 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 KOO27565.1 - 0.28 10.7 0.1 0.28 10.7 0.1 2.1 2 0 0 2 2 2 0 EF hand Lipase_3 PF01764.25 KOO27566.1 - 6.7e-35 120.0 0.0 9e-35 119.6 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 KOO27566.1 - 0.0021 18.7 4.8 0.0039 17.8 4.5 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 KOO27566.1 - 0.061 12.9 0.0 0.45 10.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) SHIPPO-rpt PF07004.12 KOO27567.1 - 5.1e-08 33.5 12.7 0.13 13.3 1.2 5.4 5 0 0 5 5 5 4 Sperm-tail PG-rich repeat CASP_C PF08172.12 KOO27568.1 - 2.6e-33 115.4 12.7 2.6e-33 115.4 12.7 3.6 1 1 2 3 3 3 1 CASP C terminal GAS PF13851.6 KOO27568.1 - 0.00077 18.9 4.1 0.00077 18.9 4.1 3.9 2 1 2 4 4 4 1 Growth-arrest specific micro-tubule binding DHR10 PF18595.1 KOO27568.1 - 0.0042 17.1 4.8 0.0042 17.1 4.8 5.0 3 2 3 6 6 6 2 Designed helical repeat protein 10 domain Flagellin_C PF00700.21 KOO27568.1 - 0.019 15.3 6.2 0.94 9.9 1.3 3.5 3 0 0 3 3 3 0 Bacterial flagellin C-terminal helical region DUF1664 PF07889.12 KOO27568.1 - 9.2 6.3 9.9 2.5 8.2 0.2 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 KOO27568.1 - 9.4 6.0 30.6 0.14 12.0 3.9 3.8 1 1 3 4 4 4 0 Protein of unknown function (DUF724) Fer2 PF00111.27 KOO27569.1 - 8.1e-07 28.9 1.5 1.3e-06 28.2 1.5 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2_3 PF13085.6 KOO27569.1 - 0.0012 18.8 0.6 0.0015 18.5 0.6 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain KH_1 PF00013.29 KOO27569.1 - 0.053 13.4 0.1 0.084 12.7 0.1 1.3 1 0 0 1 1 1 0 KH domain Fer2_4 PF13510.6 KOO27569.1 - 0.45 10.6 3.5 0.42 10.7 1.4 2.1 2 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain TMF_DNA_bd PF12329.8 KOO27571.1 - 0.0047 16.9 8.1 0.0047 16.9 8.1 6.0 4 2 3 7 7 7 2 TATA element modulatory factor 1 DNA binding PKcGMP_CC PF16808.5 KOO27571.1 - 3 7.8 15.5 4.3 7.3 0.0 5.0 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FlaC_arch PF05377.11 KOO27571.1 - 3.5 8.1 15.4 12 6.4 0.1 4.9 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) Nudc_N PF14050.6 KOO27572.1 - 2.2e-21 75.6 0.1 3.3e-21 75.0 0.1 1.3 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 KOO27572.1 - 1.6e-09 38.6 0.0 2.4e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 CS domain PaRep2a PF07903.11 KOO27572.1 - 0.35 10.7 3.0 4.4 7.2 1.6 2.7 2 1 1 3 3 3 0 PaRep2a protein Med3 PF11593.8 KOO27572.1 - 0.71 9.0 11.0 0.98 8.5 11.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF2486 PF10667.9 KOO27572.1 - 1.3 9.2 21.5 2.5 8.2 21.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) PKD_channel PF08016.12 KOO27574.1 - 3.9e-23 81.8 18.0 5.9e-21 74.6 19.4 2.4 3 0 0 3 3 3 2 Polycystin cation channel Ion_trans PF00520.31 KOO27574.1 - 2.2e-09 36.9 22.5 2.2e-09 36.9 22.5 1.8 2 0 0 2 2 2 1 Ion transport protein TcpE PF12648.7 KOO27574.1 - 0.059 13.9 0.6 0.059 13.9 0.6 3.3 4 0 0 4 4 4 0 TcpE family AP_endonuc_2 PF01261.24 KOO27575.1 - 0.0013 18.3 0.2 0.0023 17.4 0.2 1.5 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Filamin PF00630.19 KOO27578.1 - 4e-56 188.2 0.0 3.9e-13 50.1 0.0 6.7 6 1 0 6 6 6 6 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO27578.1 - 2.4e-18 66.2 3.5 2.9e-06 27.5 0.0 4.5 5 0 0 5 5 4 3 Invasin, domain 3 Cadherin_5 PF17892.1 KOO27578.1 - 2.6e-05 24.1 0.8 2.4 8.2 0.0 3.5 3 0 0 3 3 3 3 Cadherin-like domain Big_1 PF02369.16 KOO27578.1 - 5.5e-05 23.1 3.3 0.061 13.3 0.1 4.4 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.12 KOO27578.1 - 0.0033 16.9 0.2 11 5.4 0.1 3.1 3 0 0 3 3 3 1 Neurexophilin YtkA PF13115.6 KOO27578.1 - 0.0053 17.3 0.5 51 4.6 0.0 4.8 6 0 0 6 6 5 0 YtkA-like Big_3 PF07523.12 KOO27578.1 - 0.019 15.2 0.7 20 5.6 0.0 4.2 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) DUF5011 PF16403.5 KOO27578.1 - 0.039 14.1 2.2 9.6 6.4 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) BclA_C PF18573.1 KOO27578.1 - 0.099 12.5 0.5 6.8 6.6 0.0 3.6 3 1 1 4 4 4 0 BclA C-terminal domain DUF5060 PF16586.5 KOO27578.1 - 0.11 12.8 0.1 23 5.5 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) DUF3244 PF11589.8 KOO27578.1 - 0.23 11.6 0.1 4 7.6 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3244) He_PIG PF05345.12 KOO27578.1 - 1.4 9.2 9.3 0.27 11.4 1.4 3.2 3 0 0 3 3 3 0 Putative Ig domain FBPase PF00316.20 KOO27579.1 - 2.7e-18 66.1 0.4 8.6e-17 61.2 0.4 2.1 1 1 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Gly_transf_sug PF04488.15 KOO27581.1 - 4.3e-07 30.5 0.0 6.9e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 KOO27581.1 - 0.00015 21.2 0.1 0.00021 20.7 0.1 1.1 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain DUF2214 PF09980.9 KOO27583.1 - 1.2e-47 161.4 3.0 1.6e-47 161.0 3.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2214) FGAR-AT_linker PF18072.1 KOO27584.1 - 3.4e-07 30.7 1.2 4.7 7.8 0.0 5.6 4 2 1 5 5 5 4 Formylglycinamide ribonucleotide amidotransferase linker domain Sigma70_r3 PF04539.16 KOO27584.1 - 3.6e-06 27.0 22.8 0.52 10.4 4.0 7.3 4 1 2 6 6 6 4 Sigma-70 region 3 PIP5K PF01504.18 KOO27585.1 - 6.3e-75 251.9 0.0 1.1e-74 251.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PH PF00169.29 KOO27585.1 - 0.0098 16.4 0.0 0.026 15.0 0.0 1.8 1 0 0 1 1 1 1 PH domain CAP_N PF01213.19 KOO27585.1 - 0.9 9.0 6.4 1.4 8.3 6.4 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Anoctamin PF04547.12 KOO27586.1 - 1.1e-100 337.6 0.2 1.4e-100 337.2 0.2 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KOO27586.1 - 4.8e-07 29.7 0.0 1.2e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin TPR_1 PF00515.28 KOO27586.1 - 0.048 13.5 0.0 0.21 11.5 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Aldo_ket_red PF00248.21 KOO27587.1 - 6.3e-21 74.8 0.0 1.2e-09 37.8 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Pkinase PF00069.25 KOO27588.1 - 1.4e-50 172.1 0.0 1.7e-50 171.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27588.1 - 2.8e-36 125.1 0.0 3.4e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO27588.1 - 1.6e-06 27.7 0.0 2.1e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO27588.1 - 0.00078 19.4 0.1 0.0015 18.5 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinesin PF00225.23 KOO27589.1 - 1.7e-96 323.0 0.0 2e-96 322.8 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO27589.1 - 3.1e-22 79.1 0.0 7e-22 78.0 0.0 1.6 1 1 0 1 1 1 1 Microtubule binding Ank_2 PF12796.7 KOO27590.1 - 3.1e-14 53.3 0.3 3e-06 27.7 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO27590.1 - 1.1e-13 51.2 0.8 3.9e-05 23.8 0.1 3.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO27590.1 - 1.6e-13 50.9 0.0 7.9e-06 26.3 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27590.1 - 2.9e-12 45.6 0.8 0.044 14.3 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO27590.1 - 2.4e-06 27.7 7.6 0.63 10.6 0.2 4.4 4 0 0 4 4 4 3 Ankyrin repeat Sulfotransfer_3 PF13469.6 KOO27591.1 - 3.6e-15 57.0 0.0 4.6e-08 33.7 0.0 2.3 2 0 0 2 2 2 2 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO27591.1 - 4.6e-05 23.0 0.0 0.26 10.7 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase domain WD40 PF00400.32 KOO27592.1 - 2.7e-11 43.8 0.5 0.00014 22.6 0.0 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO27592.1 - 3e-07 30.6 0.0 0.013 15.8 0.0 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain CSTF1_dimer PF16699.5 KOO27592.1 - 2.4e-06 27.2 0.0 1.2e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Cleavage stimulation factor subunit 1, dimerisation domain Ge1_WD40 PF16529.5 KOO27592.1 - 0.038 13.0 0.3 5.1 6.0 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 KOO27592.1 - 0.27 11.8 1.8 1.9 9.1 0.1 3.0 3 0 0 3 3 3 0 PQQ-like domain Exostosin PF03016.15 KOO27593.1 - 2.9e-34 118.7 2.8 1.9e-32 112.7 0.1 3.1 2 1 0 2 2 2 2 Exostosin family EGF_2 PF07974.13 KOO27593.1 - 0.00014 22.1 17.7 0.0063 16.9 9.5 2.5 2 0 0 2 2 2 2 EGF-like domain EGF PF00008.27 KOO27593.1 - 0.021 15.1 7.7 3.3 8.1 4.6 2.6 2 0 0 2 2 2 0 EGF-like domain EGF_Tenascin PF18720.1 KOO27593.1 - 0.058 13.5 12.3 0.16 12.0 5.2 2.4 2 0 0 2 2 2 0 Tenascin EGF domain hEGF PF12661.7 KOO27593.1 - 0.6 10.8 9.0 0.87 10.3 3.4 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_alliinase PF04863.13 KOO27593.1 - 1.5 9.2 10.4 11 6.5 0.2 3.1 2 1 0 2 2 2 0 Alliinase EGF-like domain DUF1997 PF09366.10 KOO27595.1 - 4.9e-11 43.0 0.0 5.3e-11 42.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1997) RNB PF00773.19 KOO27596.1 - 6e-54 183.6 0.0 7.2e-52 176.7 0.0 2.1 1 1 0 1 1 1 1 RNB domain MFS_1 PF07690.16 KOO27597.1 - 9.1e-11 41.3 14.3 9.1e-11 41.3 14.3 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily PseudoU_synth_2 PF00849.22 KOO27597.1 - 0.0043 17.1 0.0 0.0069 16.5 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase EF-hand_7 PF13499.6 KOO27598.1 - 2.4e-08 34.3 4.7 0.0027 18.1 0.2 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO27598.1 - 2.3e-07 29.9 6.4 0.00013 21.2 0.6 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO27598.1 - 2.4e-06 27.3 1.2 0.032 14.1 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO27598.1 - 3.4e-05 23.4 5.6 0.0029 17.4 0.5 3.1 3 0 0 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO27598.1 - 0.029 14.7 0.1 0.077 13.3 0.1 1.7 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 KOO27598.1 - 0.053 13.0 6.2 0.11 12.0 0.1 3.1 3 0 0 3 3 3 0 EF hand EF-hand_4 PF12763.7 KOO27598.1 - 0.22 11.5 2.1 12 5.9 0.2 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.25 KOO27599.1 - 1.8e-44 152.1 0.0 2.3e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27599.1 - 2.4e-11 43.4 0.0 4.9e-11 42.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase zf-RING_UBOX PF13445.6 KOO27601.1 - 5.6e-09 35.9 8.7 1.2e-08 34.9 8.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOO27601.1 - 4.9e-08 32.7 10.3 8.4e-08 32.0 10.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO27601.1 - 1.1e-07 31.5 9.4 1.8e-07 30.9 9.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO27601.1 - 7.5e-07 28.9 14.6 1.3e-06 28.1 14.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO27601.1 - 2e-06 28.0 13.8 3.3e-06 27.3 13.8 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KOO27601.1 - 1.1e-05 25.2 7.7 1.1e-05 25.2 7.7 1.7 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOO27601.1 - 3.3e-05 23.8 12.8 5.7e-05 23.0 12.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOO27601.1 - 0.00017 21.7 11.4 0.0003 20.9 11.4 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 KOO27601.1 - 0.031 14.1 6.0 0.061 13.2 6.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FYVE PF01363.21 KOO27601.1 - 0.062 13.4 2.6 0.13 12.4 2.6 1.5 1 0 0 1 1 1 0 FYVE zinc finger zf-rbx1 PF12678.7 KOO27601.1 - 0.087 13.1 9.4 0.21 11.9 9.4 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOO27601.1 - 0.28 11.3 7.2 2 8.5 7.2 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Filamin PF00630.19 KOO27602.1 - 1.3e-140 459.6 0.0 1.3e-17 64.5 0.0 13.1 13 0 0 13 13 13 12 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO27602.1 - 2.2e-33 114.4 33.5 9.4e-05 22.6 0.3 12.2 12 0 0 12 12 12 8 Invasin, domain 3 YtkA PF13115.6 KOO27602.1 - 2.2e-13 50.6 2.1 3.3 8.4 0.0 10.5 12 0 0 12 12 12 3 YtkA-like Y_Y_Y PF07495.13 KOO27602.1 - 0.00016 21.6 4.6 7.1 6.7 0.0 6.1 6 0 0 6 6 6 1 Y_Y_Y domain CopC PF04234.12 KOO27602.1 - 0.0024 18.8 11.6 65 4.7 0.0 8.4 11 0 0 11 11 11 0 CopC domain Neurexophilin PF06312.12 KOO27602.1 - 0.0058 16.1 3.2 20 4.6 0.1 5.1 5 0 0 5 5 5 1 Neurexophilin Big_1 PF02369.16 KOO27602.1 - 0.019 15.0 29.9 1 9.4 1.2 9.2 10 2 0 10 10 10 0 Bacterial Ig-like domain (group 1) DUF5060 PF16586.5 KOO27602.1 - 0.052 13.9 0.2 50 4.4 0.0 5.4 8 0 0 8 8 8 0 Domain of unknown function (DUF5060) FixH PF05751.11 KOO27602.1 - 0.43 10.6 1.3 71 3.4 0.0 4.9 6 0 0 6 6 6 0 FixH U-box PF04564.15 KOO27605.1 - 5.1e-08 33.0 0.0 8.7e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-RING_UBOX PF13445.6 KOO27605.1 - 0.00033 20.6 0.0 0.00061 19.8 0.0 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.8 KOO27605.1 - 0.18 11.6 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit peroxidase PF00141.23 KOO27606.1 - 4.2e-37 128.0 0.0 6.4e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Peroxidase PP2C PF00481.21 KOO27607.1 - 1.2e-30 107.0 0.0 2e-30 106.3 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C cNMP_binding PF00027.29 KOO27607.1 - 6.5e-11 42.2 0.7 0.0027 17.7 0.0 4.1 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain AhpC-TSA_2 PF13911.6 KOO27607.1 - 1.7e-09 37.8 0.0 3.7e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 KOO27607.1 - 2.7e-06 27.3 0.0 5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family SpoIIE PF07228.12 KOO27607.1 - 0.00023 21.1 0.8 0.0044 17.0 0.0 2.3 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) Redoxin PF08534.10 KOO27607.1 - 0.014 15.1 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 Redoxin adh_short PF00106.25 KOO27608.1 - 6.7e-32 110.5 0.0 8.7e-32 110.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO27608.1 - 1.2e-21 77.3 0.0 1.5e-21 77.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO27608.1 - 2.7e-08 33.9 0.0 3.5e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 KR domain EF-hand_6 PF13405.6 KOO27609.1 - 1.7e-32 108.5 0.2 1.9e-05 24.2 0.0 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_1 PF00036.32 KOO27609.1 - 4.3e-32 107.3 0.2 7.7e-07 28.2 0.0 5.9 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 KOO27609.1 - 2.3e-27 95.2 0.0 4.8e-10 39.7 0.0 3.9 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO27609.1 - 3e-24 83.4 3.1 2.3e-05 23.7 0.0 5.5 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.6 KOO27609.1 - 5.2e-20 71.0 0.0 3.4e-07 30.0 0.1 4.3 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO27609.1 - 9.5e-06 25.9 0.6 0.049 13.9 0.0 4.0 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region SQAPI PF16845.5 KOO27610.1 - 0.0002 21.6 0.1 0.00052 20.3 0.1 1.8 1 1 1 2 2 2 1 Aspartic acid proteinase inhibitor Cystatin PF00031.21 KOO27610.1 - 0.0029 17.8 0.0 0.0044 17.2 0.0 1.4 1 0 0 1 1 1 1 Cystatin domain MIT PF04212.18 KOO27611.1 - 5.8e-21 74.3 1.6 5.8e-21 74.3 1.6 2.7 3 0 0 3 3 2 1 MIT (microtubule interacting and transport) domain SAM_1 PF00536.30 KOO27611.1 - 2.5e-19 69.5 0.2 8.3e-14 51.8 0.0 3.1 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO27611.1 - 8.9e-16 57.8 1.2 5.3e-11 42.5 0.0 3.0 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) AAA PF00004.29 KOO27611.1 - 3.6e-14 53.3 0.1 1e-13 51.9 0.1 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOO27611.1 - 1.8e-06 27.8 0.1 3.8e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KOO27611.1 - 6.9e-05 23.4 0.1 0.0011 19.5 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO27611.1 - 0.0002 21.6 0.6 0.019 15.2 0.0 3.1 2 1 0 2 2 2 1 AAA domain SAM_4 PF18017.1 KOO27611.1 - 0.0021 18.0 0.0 0.0064 16.4 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) AAA_2 PF07724.14 KOO27611.1 - 0.0026 17.9 0.2 0.0061 16.7 0.2 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF1192 PF06698.11 KOO27611.1 - 0.0027 17.7 0.7 0.014 15.5 0.7 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) Viral_helicase1 PF01443.18 KOO27611.1 - 0.0029 17.4 0.0 0.0058 16.4 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 KOO27611.1 - 0.0064 16.4 0.2 0.015 15.2 0.2 1.7 1 0 0 1 1 1 1 NTPase Sigma54_activat PF00158.26 KOO27611.1 - 0.0064 16.2 0.2 0.25 11.1 0.2 2.5 1 1 0 1 1 1 1 Sigma-54 interaction domain RNA_helicase PF00910.22 KOO27611.1 - 0.0093 16.3 0.2 0.054 13.9 0.0 2.3 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 KOO27611.1 - 0.011 15.7 0.1 0.025 14.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOO27611.1 - 0.014 14.8 0.0 0.22 10.9 0.0 2.1 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KOO27611.1 - 0.017 15.5 0.8 0.078 13.3 0.1 2.3 2 1 1 3 3 3 0 AAA ATPase domain AAA_30 PF13604.6 KOO27611.1 - 0.017 14.9 0.4 0.045 13.5 0.4 1.7 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 KOO27611.1 - 0.021 14.3 0.0 0.044 13.2 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_19 PF13245.6 KOO27611.1 - 0.022 15.1 1.1 0.39 11.0 1.1 3.1 1 1 0 1 1 1 0 AAA domain Cytochrome_P460 PF16694.5 KOO27611.1 - 0.024 15.0 0.4 0.051 13.9 0.4 1.5 1 0 0 1 1 1 0 Cytochrome P460 EAP30 PF04157.16 KOO27611.1 - 0.028 13.7 0.5 0.19 11.0 0.3 2.2 2 1 0 2 2 2 0 EAP30/Vps36 family TsaE PF02367.17 KOO27611.1 - 0.039 14.0 1.3 0.75 9.8 0.0 2.9 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE tRNA_lig_kinase PF08303.11 KOO27611.1 - 0.1 12.7 0.3 0.97 9.5 0.0 2.6 2 2 1 4 4 3 0 tRNA ligase kinase domain AAA_33 PF13671.6 KOO27611.1 - 0.11 12.7 0.0 0.37 10.9 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_lid_6 PF17866.1 KOO27611.1 - 0.12 12.6 0.1 0.38 11.0 0.1 1.9 1 0 0 1 1 1 0 AAA lid domain ABC_tran PF00005.27 KOO27611.1 - 0.12 12.9 0.3 0.36 11.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter TPR_2 PF07719.17 KOO27611.1 - 0.14 12.3 1.1 0.81 10.0 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat CHAD PF05235.14 KOO27613.1 - 0.016 15.2 3.9 0.016 15.2 3.9 1.2 1 0 0 1 1 1 0 CHAD domain Sacchrp_dh_NADP PF03435.18 KOO27614.1 - 2.8e-12 47.0 0.0 4.9e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 KOO27614.1 - 0.015 15.2 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding TetR_C_30 PF17939.1 KOO27615.1 - 0.035 14.3 0.7 8.6 6.6 0.1 2.7 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Cpn60_TCP1 PF00118.24 KOO27615.1 - 0.24 10.0 0.0 0.34 9.5 0.0 1.1 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family PDZ PF00595.24 KOO27617.1 - 1.9e-05 24.9 0.1 4e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO27617.1 - 0.00058 19.6 0.2 0.0072 16.1 0.1 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO27617.1 - 0.00093 19.5 0.3 0.0021 18.3 0.3 1.6 1 0 0 1 1 1 1 PDZ domain DUF3775 PF12616.8 KOO27617.1 - 0.28 11.2 1.7 0.42 10.7 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3775) AFG1_ATPase PF03969.16 KOO27618.1 - 2.3e-36 125.5 0.4 1.7e-30 106.2 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase Mtc PF03820.17 KOO27619.1 - 3.6e-33 115.0 0.3 5.4e-33 114.4 0.3 1.2 1 0 0 1 1 1 1 Tricarboxylate carrier Fer2 PF00111.27 KOO27619.1 - 0.00012 22.0 1.2 0.00017 21.5 0.4 1.7 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer2_3 PF13085.6 KOO27619.1 - 0.0044 17.0 0.5 0.008 16.2 0.5 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF4813 PF16072.5 KOO27619.1 - 0.045 13.4 7.3 0.065 12.9 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Med14 PF08638.11 KOO27620.1 - 1.1e-23 83.7 0.0 2.8e-23 82.3 0.0 1.7 2 0 0 2 2 2 1 Mediator complex subunit MED14 Pkinase PF00069.25 KOO27621.1 - 5e-22 78.5 0.0 1.5e-21 77.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27621.1 - 1.6e-18 66.9 0.0 2.7e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO27621.1 - 0.39 10.6 13.9 0.11 12.4 9.2 2.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family Anoctamin PF04547.12 KOO27622.1 - 2.4e-91 306.8 0.0 3.6e-91 306.3 0.0 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel C2 PF00168.30 KOO27622.1 - 2.9e-16 59.6 0.0 1.1e-12 48.2 0.0 2.5 2 0 0 2 2 2 2 C2 domain Anoct_dimer PF16178.5 KOO27622.1 - 2.6e-07 30.6 0.1 5.5e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin BSD PF03909.17 KOO27622.1 - 0.005 16.8 0.0 39 4.3 0.0 3.7 3 0 0 3 3 3 0 BSD domain Phage_Gp23 PF10669.9 KOO27622.1 - 0.027 14.8 0.3 0.027 14.8 0.3 2.3 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) TPR_MLP1_2 PF07926.12 KOO27623.1 - 0.012 15.7 34.2 0.015 15.3 10.8 2.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF2895 PF11444.8 KOO27623.1 - 0.1 12.0 0.8 0.19 11.1 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) HMMR_N PF15905.5 KOO27623.1 - 0.16 11.4 19.8 0.1 12.0 10.1 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Leu_zip PF15294.6 KOO27623.1 - 0.42 10.1 22.1 0.51 9.8 11.8 2.1 1 1 1 2 2 2 0 Leucine zipper DUF1664 PF07889.12 KOO27623.1 - 1.9 8.5 12.5 7.6 6.6 0.4 3.0 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Lectin_N PF03954.14 KOO27623.1 - 2.2 8.1 5.4 2.7 7.8 0.5 2.6 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Seryl_tRNA_N PF02403.22 KOO27623.1 - 3.3 8.0 24.3 6.6 7.0 4.4 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Golgin_A5 PF09787.9 KOO27623.1 - 4.1 6.8 25.1 2.7 7.4 16.4 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 HIP1_clath_bdg PF16515.5 KOO27623.1 - 4.6 7.9 28.2 0.18 12.4 8.4 2.4 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc7 PF08317.11 KOO27623.1 - 4.8 6.0 28.1 2.1 7.2 6.9 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Rx_N PF18052.1 KOO27623.1 - 5.2 7.4 13.2 0.42 10.9 1.3 2.9 1 1 2 3 3 3 0 Rx N-terminal domain GvpG PF05120.12 KOO27623.1 - 5.9 7.0 13.9 0.55 10.3 2.5 2.9 2 2 1 3 3 3 0 Gas vesicle protein G Tup_N PF08581.10 KOO27623.1 - 6.4 7.2 12.4 0.38 11.1 2.9 3.2 2 2 0 2 2 2 0 Tup N-terminal Nup88 PF10168.9 KOO27623.1 - 7.9 4.2 17.2 9.9 3.8 17.2 1.1 1 0 0 1 1 1 0 Nuclear pore component Jnk-SapK_ap_N PF09744.9 KOO27623.1 - 8.9 6.5 26.4 1.2 9.4 10.1 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TMF_DNA_bd PF12329.8 KOO27623.1 - 9.5 6.3 19.5 1.2 9.2 6.8 3.4 2 2 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Kinesin PF00225.23 KOO27624.1 - 1.5e-27 96.4 0.0 3e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain TPR_12 PF13424.6 KOO27624.1 - 1.8e-10 41.0 10.2 2.4e-10 40.6 1.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat VHS PF00790.19 KOO27624.1 - 2.4e-06 27.4 0.1 7.3e-06 25.9 0.1 1.8 1 0 0 1 1 1 1 VHS domain TPR_8 PF13181.6 KOO27624.1 - 0.00058 19.9 1.1 4 7.9 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO27624.1 - 0.00067 20.1 1.1 0.055 14.0 0.3 3.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO27624.1 - 0.0032 17.2 5.0 1.3 8.9 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27624.1 - 0.0038 17.2 10.9 4.4 7.6 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MLP1_2 PF07926.12 KOO27624.1 - 0.0082 16.2 3.1 0.0082 16.2 3.1 6.6 7 0 0 7 7 7 1 TPR/MLP1/MLP2-like protein TPR_11 PF13414.6 KOO27624.1 - 0.016 14.8 1.9 2.1 8.1 0.1 3.5 3 0 0 3 3 3 0 TPR repeat TPR_7 PF13176.6 KOO27624.1 - 0.017 15.1 7.7 5.8 7.2 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO27624.1 - 0.037 13.9 0.3 0.037 13.9 0.3 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27624.1 - 0.22 12.2 11.8 0.092 13.4 2.3 4.0 3 1 1 4 4 3 0 Tetratricopeptide repeat NPV_P10 PF05531.12 KOO27624.1 - 0.96 10.0 3.4 8.9 6.9 0.7 3.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein SHE3 PF17078.5 KOO27624.1 - 7.8 6.1 12.9 0.61 9.8 6.3 2.4 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 DnaJ PF00226.31 KOO27625.1 - 3e-17 62.5 0.1 6e-17 61.5 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain WW PF00397.26 KOO27625.1 - 3e-08 33.6 2.1 5.5e-08 32.8 2.1 1.5 1 0 0 1 1 1 1 WW domain DUF4551 PF15087.6 KOO27625.1 - 0.38 9.5 5.2 0.5 9.1 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) GREB1 PF15782.5 KOO27625.1 - 0.89 6.6 2.1 1.1 6.3 2.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Caps_synth PF05704.12 KOO27626.1 - 1.4e-08 34.5 0.0 2.7e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 KOO27626.1 - 2.5e-05 24.8 0.1 8.7e-05 23.1 0.1 1.9 1 1 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif ABC2_membrane PF01061.24 KOO27628.1 - 4e-28 98.3 12.4 4e-28 98.3 12.4 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KOO27628.1 - 1.2e-23 84.2 0.0 1.6e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOO27628.1 - 2.4e-08 34.2 0.0 0.00028 20.8 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO27628.1 - 1.7e-05 24.4 0.1 0.019 14.4 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 KOO27628.1 - 0.00054 19.2 18.4 0.0006 19.0 17.7 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 KOO27628.1 - 0.0008 19.4 0.1 0.0013 18.7 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 KOO27628.1 - 0.0011 18.7 0.1 0.0025 17.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 KOO27628.1 - 0.027 14.9 0.1 0.099 13.1 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOO27628.1 - 0.031 14.5 0.3 0.08 13.2 0.2 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO27628.1 - 0.034 14.5 0.1 0.063 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 KOO27628.1 - 0.056 13.9 0.1 0.088 13.3 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOO27628.1 - 0.068 12.7 0.6 0.14 11.7 0.2 1.7 2 0 0 2 2 2 0 AAA domain LMBR1 PF04791.16 KOO27628.1 - 0.09 11.7 7.8 0.012 14.6 2.7 1.9 1 1 1 2 2 2 0 LMBR1-like membrane protein Rad17 PF03215.15 KOO27628.1 - 0.1 12.5 0.1 0.17 11.8 0.1 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 KOO27628.1 - 0.2 11.8 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 KOO27628.1 - 0.25 11.0 0.0 13 5.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Thioredoxin_2 PF13098.6 KOO27629.1 - 0.015 15.7 0.0 0.017 15.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_3 PF13192.6 KOO27629.1 - 0.041 13.9 0.0 0.063 13.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin domain EF-hand_1 PF00036.32 KOO27630.1 - 3.1e-22 76.4 6.2 1.5e-05 24.2 0.0 6.4 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.6 KOO27630.1 - 7.4e-22 75.4 4.7 9.2e-05 22.1 0.0 6.2 6 1 0 6 6 6 4 EF-hand domain EF-hand_7 PF13499.6 KOO27630.1 - 2e-21 76.2 0.3 1.9e-08 34.6 0.0 4.3 2 1 3 5 5 5 5 EF-hand domain pair EF-hand_8 PF13833.6 KOO27630.1 - 1.7e-18 66.2 0.0 8.6e-05 22.3 0.0 4.0 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO27630.1 - 3.9e-10 38.7 7.4 0.0051 16.2 0.0 5.4 6 0 0 6 6 6 3 EF hand DUF5580 PF17743.1 KOO27630.1 - 0.005 15.4 0.0 0.0084 14.7 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_10 PF14788.6 KOO27630.1 - 0.0078 16.1 0.2 0.077 12.9 0.0 2.4 2 0 0 2 2 2 1 EF hand DUF3856 PF12968.7 KOO27630.1 - 0.13 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) Ribul_P_3_epim PF00834.19 KOO27631.1 - 8.3e-68 227.7 1.2 2.6e-65 219.6 1.2 2.1 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 KOO27631.1 - 2.6e-07 30.6 0.1 0.00034 20.4 0.0 2.2 2 0 0 2 2 2 2 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 KOO27631.1 - 0.017 14.6 0.1 0.14 11.6 0.0 2.0 2 0 0 2 2 2 0 Histidine biosynthesis protein TMP-TENI PF02581.17 KOO27631.1 - 0.033 13.5 0.5 0.4 10.0 0.1 2.6 3 0 0 3 3 3 0 Thiamine monophosphate synthase DUF1995 PF09353.10 KOO27632.1 - 1.9e-10 41.1 0.0 2.3e-10 40.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) Ank_2 PF12796.7 KOO27633.1 - 2.5e-17 63.2 0.0 1.2e-10 41.8 0.0 2.9 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO27633.1 - 2.7e-11 43.4 0.9 2.1e-05 24.8 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 KOO27633.1 - 6.3e-11 42.6 1.2 4.2e-05 24.0 0.4 4.4 2 2 2 4 4 4 3 Ankyrin repeats (many copies) EF-hand_1 PF00036.32 KOO27633.1 - 8.4e-11 40.6 3.3 0.00015 21.1 0.2 2.8 2 0 0 2 2 2 2 EF hand Ank_5 PF13857.6 KOO27633.1 - 1.4e-09 38.0 1.5 0.05 13.9 0.0 5.0 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27633.1 - 5.6e-08 32.4 2.2 0.033 14.7 0.0 5.5 3 1 1 4 4 4 1 Ankyrin repeat EF-hand_7 PF13499.6 KOO27633.1 - 6.8e-07 29.7 2.0 6.5e-06 26.5 1.7 2.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO27633.1 - 4.2e-06 26.3 0.4 0.031 14.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO27633.1 - 0.035 14.0 5.5 3.3 7.6 1.2 2.9 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_11 PF08976.11 KOO27633.1 - 0.038 14.9 0.0 0.072 14.0 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain Gamma_PGA_hydro PF05908.11 KOO27633.1 - 0.039 13.4 0.0 0.078 12.4 0.0 1.4 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase EF-hand_5 PF13202.6 KOO27633.1 - 0.41 10.2 0.0 0.41 10.2 0.0 2.8 3 0 0 3 3 3 0 EF hand BT1 PF03092.16 KOO27634.1 - 2.5e-13 49.1 18.1 1.3e-11 43.5 1.1 2.2 2 0 0 2 2 2 2 BT1 family Methyltransf_24 PF13578.6 KOO27634.1 - 0.016 16.2 0.0 0.032 15.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Na_Ca_ex PF01699.24 KOO27635.1 - 4.2e-20 72.2 14.3 4.2e-20 72.2 14.3 1.5 2 0 0 2 2 2 1 Sodium/calcium exchanger protein Calx-beta PF03160.14 KOO27635.1 - 0.0027 17.8 0.2 0.0059 16.7 0.0 1.6 2 0 0 2 2 2 1 Calx-beta domain Chlam_vir PF05475.11 KOO27635.1 - 0.044 13.5 0.1 0.33 10.7 0.0 2.3 2 0 0 2 2 2 0 Pgp3 C-terminal domain DHHC PF01529.20 KOO27635.1 - 5 7.2 6.7 1.2e+02 2.8 6.7 2.4 1 1 0 1 1 1 0 DHHC palmitoyltransferase Nuc_sug_transp PF04142.15 KOO27636.1 - 2e-28 99.5 17.6 4.4e-28 98.4 17.6 1.5 1 0 0 1 1 1 1 Nucleotide-sugar transporter Ion_trans_2 PF07885.16 KOO27636.1 - 5.8e-12 45.4 12.7 4.3e-07 29.8 3.7 4.0 2 0 0 2 2 2 2 Ion channel FlgM PF04316.13 KOO27636.1 - 0.34 11.3 2.2 1.1 9.7 2.2 1.8 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM DUF5325 PF17259.2 KOO27636.1 - 4.5 7.2 6.5 6.8 6.6 2.9 3.4 2 0 0 2 2 2 0 Family of unknown function (DUF5325) SAS-6_N PF16531.5 KOO27637.1 - 3.6e-27 94.8 0.4 6.9e-27 93.9 0.4 1.5 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal DUF1664 PF07889.12 KOO27637.1 - 5.5 7.0 9.3 14 5.7 0.2 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Mob_Pre PF01076.19 KOO27638.1 - 0.0066 16.3 0.3 0.0086 15.9 0.3 1.2 1 0 0 1 1 1 1 Plasmid recombination enzyme Tcf25 PF04910.14 KOO27638.1 - 0.047 12.8 0.6 0.049 12.7 0.6 1.0 1 0 0 1 1 1 0 Transcriptional repressor TCF25 PG_binding_4 PF12229.8 KOO27638.1 - 0.089 13.1 0.1 0.1 12.9 0.1 1.2 1 0 0 1 1 1 0 Putative peptidoglycan binding domain DSPc PF00782.20 KOO27639.1 - 6.8e-07 29.2 0.0 1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KOO27639.1 - 1.2e-05 25.5 0.0 1.9e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KOO27639.1 - 0.00041 20.4 0.1 0.00061 19.8 0.1 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KOO27639.1 - 0.0083 15.7 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase KELK PF15796.5 KOO27640.1 - 0.025 15.0 0.5 0.038 14.4 0.5 1.2 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Na_Ca_ex PF01699.24 KOO27642.1 - 3.2e-42 144.0 31.5 6.7e-22 78.1 13.6 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Calx-beta PF03160.14 KOO27642.1 - 2.3e-36 123.9 1.2 6.9e-21 74.3 0.3 2.3 2 0 0 2 2 2 2 Calx-beta domain DUF3040 PF11239.8 KOO27642.1 - 3 8.2 5.8 20 5.6 0.1 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3040) DUF1218 PF06749.12 KOO27642.1 - 3.4 8.3 9.5 1.9 9.1 0.7 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) Chloroa_b-bind PF00504.21 KOO27643.1 - 5.9e-37 127.7 0.1 7.7e-37 127.3 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Seryl_tRNA_N PF02403.22 KOO27644.1 - 0.044 14.0 0.5 0.044 14.0 0.5 3.9 4 1 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.11 KOO27644.1 - 0.18 11.9 0.0 0.18 11.9 0.0 2.8 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ACP_PD PF04336.12 KOO27644.1 - 0.26 11.7 0.1 0.26 11.7 0.1 2.8 3 0 0 3 3 3 0 Acyl carrier protein phosphodiesterase PMT_4TMC PF16192.5 KOO27646.1 - 0.0054 16.3 2.0 0.014 15.0 2.0 1.6 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase DUF2061 PF09834.9 KOO27646.1 - 0.063 13.8 1.5 0.063 13.8 1.5 3.5 4 0 0 4 4 4 0 Predicted membrane protein (DUF2061) Internalin_N PF12354.8 KOO27646.1 - 0.21 11.7 1.0 2.9 8.0 0.1 2.8 2 0 0 2 2 2 0 Bacterial adhesion/invasion protein N terminal Peptidase_M3 PF01432.20 KOO27647.1 - 6.8e-21 75.1 0.0 3e-20 72.9 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M3 Peptidase_M32 PF02074.15 KOO27647.1 - 0.0094 14.8 0.0 0.5 9.1 0.0 2.5 3 0 0 3 3 3 2 Carboxypeptidase Taq (M32) metallopeptidase DUF4033 PF13225.6 KOO27648.1 - 2.5e-14 53.0 0.1 4e-14 52.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4033) PAGK PF15284.6 KOO27649.1 - 0.042 13.8 16.9 13 5.8 0.3 6.0 4 2 2 6 6 6 0 Phage-encoded virulence factor OHA PF14418.6 KOO27649.1 - 0.76 9.6 1.7 1e+02 2.8 0.0 3.3 3 0 0 3 3 3 0 OST-HTH Associated domain Fasciclin PF02469.22 KOO27650.1 - 5.8e-10 39.5 0.0 1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Fasciclin domain Ras PF00071.22 KOO27651.1 - 1e-16 60.9 0.0 1.2e-16 60.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO27651.1 - 4.6e-14 52.7 0.0 5.9e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO27651.1 - 0.16 11.4 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family Tudor_3 PF18115.1 KOO27652.1 - 0.0058 16.4 0.0 3.3 7.6 0.0 3.6 4 0 0 4 4 4 2 DNA repair protein Crb2 Tudor domain Peptidase_S10 PF00450.22 KOO27653.1 - 1.2e-84 285.2 0.0 1.6e-84 284.8 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Thioredoxin PF00085.20 KOO27653.1 - 2.8e-07 30.5 0.0 5.8e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KOO27653.1 - 0.21 10.9 0.0 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Spc7 PF08317.11 KOO27654.1 - 4.5e-05 22.5 9.2 4.5e-05 22.5 9.2 1.5 2 0 0 2 2 2 1 Spc7 kinetochore protein Tropomyosin PF00261.20 KOO27654.1 - 0.00038 19.9 6.0 0.00038 19.9 6.0 1.5 2 0 0 2 2 2 1 Tropomyosin CENP-F_leu_zip PF10473.9 KOO27654.1 - 0.0011 19.0 9.8 0.0025 17.8 9.8 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lectin_N PF03954.14 KOO27654.1 - 0.0018 18.0 8.5 0.0036 17.0 1.1 2.9 2 1 1 3 3 3 1 Hepatic lectin, N-terminal domain TMF_DNA_bd PF12329.8 KOO27654.1 - 0.0048 16.9 12.7 0.018 15.0 9.6 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding EzrA PF06160.12 KOO27654.1 - 0.0059 14.8 4.8 0.0059 14.8 4.8 1.5 2 0 0 2 2 2 1 Septation ring formation regulator, EzrA YscO PF07321.12 KOO27654.1 - 0.0093 15.9 6.2 0.0093 15.9 6.2 2.9 2 1 1 3 3 3 1 Type III secretion protein YscO Atg14 PF10186.9 KOO27654.1 - 0.017 14.2 8.6 0.046 12.8 8.6 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 KOO27654.1 - 0.02 15.4 13.7 0.02 15.4 13.7 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region Fmp27_WPPW PF10359.9 KOO27654.1 - 0.025 13.5 4.3 0.041 12.7 4.3 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain GIT_CC PF16559.5 KOO27654.1 - 0.032 14.1 1.4 0.032 14.1 1.4 2.1 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF16 PF01519.16 KOO27654.1 - 0.04 14.4 8.1 0.069 13.6 5.6 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 ATG16 PF08614.11 KOO27654.1 - 0.049 13.9 15.8 0.067 13.4 13.2 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) SKA1 PF07160.12 KOO27654.1 - 0.051 13.4 3.1 1.3 8.8 1.5 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 SlyX PF04102.12 KOO27654.1 - 0.056 14.1 2.5 0.056 14.1 2.5 2.9 2 1 1 3 3 3 0 SlyX HAUS-augmin3 PF14932.6 KOO27654.1 - 0.074 12.6 12.3 0.068 12.7 8.5 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 XhlA PF10779.9 KOO27654.1 - 0.075 13.2 0.7 0.075 13.2 0.7 2.0 3 0 0 3 3 1 0 Haemolysin XhlA HOOK PF05622.12 KOO27654.1 - 0.078 11.1 8.2 0.15 10.2 8.2 1.4 1 0 0 1 1 1 0 HOOK protein MT PF12777.7 KOO27654.1 - 0.11 11.4 0.7 0.37 9.8 0.6 1.7 2 0 0 2 2 2 0 Microtubule-binding stalk of dynein motor SoDot-IcmSS PF16848.5 KOO27654.1 - 0.17 11.9 4.2 0.11 12.4 1.8 1.9 2 0 0 2 2 2 0 Substrate of the Dot/Icm secretion system, putative Peptidase_M3_N PF08439.10 KOO27654.1 - 0.17 12.1 0.2 0.17 12.1 0.2 2.5 2 1 0 2 2 2 0 Oligopeptidase F Lipoprotein_20 PF13942.6 KOO27654.1 - 0.17 11.8 8.6 0.31 11.0 8.6 1.4 1 0 0 1 1 1 0 YfhG lipoprotein V_ATPase_I PF01496.19 KOO27654.1 - 0.52 8.2 2.0 0.82 7.5 2.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ADIP PF11559.8 KOO27654.1 - 0.59 10.2 15.2 0.032 14.3 9.3 1.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4763 PF15960.5 KOO27654.1 - 0.94 8.7 10.9 0.17 11.1 7.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Exonuc_VII_L PF02601.15 KOO27654.1 - 1.1 8.8 4.9 1.1 8.8 3.2 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF724 PF05266.14 KOO27654.1 - 1.5 8.6 7.5 0.77 9.6 4.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF724) ERM PF00769.19 KOO27654.1 - 1.7 8.4 14.9 0.05 13.4 8.3 1.6 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Prefoldin_3 PF13758.6 KOO27654.1 - 1.9 8.6 7.4 10 6.2 0.1 3.0 2 1 1 3 3 3 0 Prefoldin subunit HemX PF04375.14 KOO27654.1 - 2.2 7.5 12.3 0.22 10.8 8.1 1.4 2 0 0 2 2 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Fib_alpha PF08702.10 KOO27654.1 - 3.4 7.9 7.0 1.6 8.9 1.1 2.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family CCDC-167 PF15188.6 KOO27654.1 - 3.5 8.0 12.1 13 6.2 4.5 2.5 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Jnk-SapK_ap_N PF09744.9 KOO27654.1 - 4.7 7.4 18.5 1.6 9.0 13.5 1.9 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 BLOC1_2 PF10046.9 KOO27654.1 - 6.2 7.2 8.6 11 6.4 2.1 2.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 UPF0242 PF06785.11 KOO27654.1 - 6.9 6.7 13.0 2.6 8.1 9.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Seryl_tRNA_N PF02403.22 KOO27654.1 - 7.8 6.8 8.8 3.6 7.9 6.1 1.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 KOO27654.1 - 8.2 7.0 18.1 0.35 11.3 6.1 2.7 2 1 1 3 3 3 0 Cell division protein ZapB DUF4200 PF13863.6 KOO27654.1 - 9.9 6.6 17.0 11 6.5 10.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Ank_2 PF12796.7 KOO27656.1 - 1.4e-47 160.2 6.1 3.9e-15 56.2 0.0 5.0 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO27656.1 - 7.3e-38 128.5 10.4 7e-10 39.2 0.1 7.4 3 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27656.1 - 2e-32 107.5 6.0 0.00027 21.1 0.0 9.0 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 KOO27656.1 - 6.4e-29 99.6 8.2 4e-05 23.8 0.0 8.0 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 KOO27656.1 - 2.4e-24 84.7 13.6 0.00017 21.9 0.0 8.6 9 0 0 9 9 9 7 Ankyrin repeat SR1P PF13790.6 KOO27656.1 - 0.043 13.9 0.3 2.8 8.1 0.1 2.7 3 0 0 3 3 3 0 SR1 protein zf-CHY PF05495.12 KOO27657.1 - 5.6e-09 36.4 7.7 5.6e-09 36.4 7.7 3.3 3 0 0 3 3 3 1 CHY zinc finger DUF4748 PF15932.5 KOO27657.1 - 0.021 14.5 0.2 0.021 14.5 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4748) ResB PF05140.14 KOO27657.1 - 2.3 6.8 5.3 4.3 6.0 4.9 1.5 1 1 0 1 1 1 0 ResB-like family RPAP1_N PF08621.10 KOO27657.1 - 3.9 7.3 9.8 0.39 10.5 4.2 2.3 2 0 0 2 2 2 0 RPAP1-like, N-terminal EF-hand_1 PF00036.32 KOO27658.1 - 2.3e-17 61.2 0.4 1.2e-08 33.9 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO27658.1 - 1.3e-15 56.0 1.0 6.3e-08 31.9 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO27658.1 - 2.6e-14 52.8 0.0 2.9e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO27658.1 - 1.9e-12 46.1 0.7 2.4e-06 26.8 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO27658.1 - 2e-11 44.2 0.0 2.7e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair Caleosin PF05042.13 KOO27658.1 - 0.00081 19.4 0.2 0.097 12.6 0.0 2.0 1 1 1 2 2 2 1 Caleosin related protein EF-hand_10 PF14788.6 KOO27658.1 - 0.0036 17.1 0.1 0.48 10.3 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 KOO27658.1 - 0.0069 16.3 0.0 1.4 8.9 0.0 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO27658.1 - 0.024 14.9 0.0 0.24 11.7 0.0 2.0 1 1 0 1 1 1 0 EF-hand domain p25-alpha PF05517.12 KOO27658.1 - 0.086 13.0 0.0 0.6 10.3 0.0 1.9 2 0 0 2 2 2 0 p25-alpha EF-hand_14 PF17959.1 KOO27658.1 - 0.2 12.0 0.1 5.8 7.3 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain Diphthamide_syn PF01866.17 KOO27659.1 - 2.5e-112 375.3 0.0 3.1e-112 374.9 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Acetyltransf_10 PF13673.7 KOO27659.1 - 5.3e-11 42.6 0.0 8.3e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO27659.1 - 1.4e-09 38.2 0.0 2.6e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO27659.1 - 1.6e-08 34.8 0.0 3.5e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO27659.1 - 3.4e-05 23.7 0.0 6.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 KOO27659.1 - 0.03 14.4 0.0 0.065 13.4 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 KOO27659.1 - 0.032 14.3 0.0 0.059 13.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SurE PF01975.17 KOO27659.1 - 0.057 13.2 0.0 0.099 12.4 0.0 1.3 1 0 0 1 1 1 0 Survival protein SurE DUF5331 PF17265.2 KOO27659.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5331) Acetyltransf_8 PF13523.6 KOO27659.1 - 0.14 11.8 0.1 0.26 10.9 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KOO27659.1 - 0.19 11.8 0.0 0.32 11.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain EF-hand_1 PF00036.32 KOO27660.1 - 1.3e-28 96.3 15.7 4.8e-06 25.7 0.2 6.9 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO27660.1 - 1.8e-27 92.8 9.9 1.2e-05 24.9 0.1 6.9 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.6 KOO27660.1 - 4.2e-25 88.0 10.4 8.3e-09 35.8 0.3 6.2 4 2 1 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO27660.1 - 4.7e-17 60.6 11.8 0.00091 18.6 0.4 6.2 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.6 KOO27660.1 - 2.3e-14 53.0 11.3 0.0018 18.1 0.0 6.0 4 1 1 5 5 5 5 EF-hand domain pair SPOB_a PF14689.6 KOO27660.1 - 0.32 10.7 3.1 64 3.4 0.1 4.1 3 0 0 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain HAD_2 PF13419.6 KOO27660.1 - 2.6 8.1 4.8 3.6 7.6 1.2 3.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase VPS11_C PF12451.8 KOO27662.1 - 0.057 13.7 0.0 0.077 13.2 0.0 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal Chromo PF00385.24 KOO27663.1 - 3e-14 52.7 0.6 5.1e-14 51.9 0.6 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF4805 PF16063.5 KOO27663.1 - 1.5 8.1 6.4 0.12 11.7 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4805) Pkinase PF00069.25 KOO27664.1 - 1.5e-44 152.4 0.0 1.8e-44 152.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27664.1 - 2.3e-25 89.3 0.0 3e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO27664.1 - 0.0044 16.4 0.0 0.0069 15.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO27664.1 - 0.009 16.0 0.0 0.028 14.4 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO27664.1 - 0.21 10.5 0.0 0.26 10.2 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain YbaB_DNA_bd PF02575.16 KOO27665.1 - 2.4e-13 50.1 2.3 2.4e-13 50.1 2.3 1.5 2 0 0 2 2 2 1 YbaB/EbfC DNA-binding family MFS_1 PF07690.16 KOO27666.1 - 9.8e-14 51.0 49.9 5.8e-08 32.0 35.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RNA_pol_Rbc25 PF08292.12 KOO27667.1 - 1.3e-29 103.1 0.0 1.3e-27 96.5 0.0 2.1 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 KOO27667.1 - 2.6e-16 59.7 0.1 4.2e-16 59.1 0.1 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DUF3720 PF12517.8 KOO27667.1 - 2 9.4 8.3 1.3 10.0 6.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3720) TALPID3 PF15324.6 KOO27667.1 - 2.2 5.8 9.7 2.9 5.5 9.7 1.0 1 0 0 1 1 1 0 Hedgehog signalling target RrnaAD PF00398.20 KOO27668.1 - 9.3e-56 188.8 0.0 1.1e-55 188.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 KOO27668.1 - 2.2e-06 28.3 0.0 4.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO27668.1 - 0.0067 17.0 0.0 0.014 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO27668.1 - 0.0097 16.6 0.0 0.022 15.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO27668.1 - 0.01 15.6 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOO27668.1 - 0.034 13.9 0.0 0.085 12.7 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain DREV PF05219.12 KOO27668.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Ubie_methyltran PF01209.18 KOO27668.1 - 0.2 11.0 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 KOO27668.1 - 0.21 11.2 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 KOO27668.1 - 0.23 10.8 0.0 0.36 10.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MRG PF05712.13 KOO27670.1 - 1.7e-42 145.0 0.3 2.7e-42 144.3 0.3 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 KOO27670.1 - 9.1e-06 25.5 0.0 1.6e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 KOO27670.1 - 0.031 14.2 0.0 0.077 12.9 0.0 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Ribonuc_2-5A PF06479.12 KOO27670.1 - 0.037 14.2 0.1 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Ribonuclease 2-5A TM140 PF14985.6 KOO27670.1 - 0.042 13.4 0.0 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 TM140 protein family Histidinol_dh PF00815.20 KOO27671.1 - 4e-100 335.7 6.9 5.8e-100 335.2 6.9 1.1 1 0 0 1 1 1 1 Histidinol dehydrogenase HisG PF01634.18 KOO27671.1 - 8.7e-50 168.8 0.0 1.9e-49 167.7 0.0 1.6 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 KOO27671.1 - 7.3e-23 80.5 0.2 1.9e-22 79.2 0.1 1.8 2 0 0 2 2 2 1 HisG, C-terminal domain ABC2_membrane PF01061.24 KOO27672.1 - 7.9e-44 149.6 16.2 1.4e-43 148.8 16.2 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 KOO27672.1 - 9.3e-18 65.1 0.0 1.5e-17 64.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 KOO27672.1 - 0.00057 19.1 7.8 0.00057 19.1 7.8 2.1 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_25 PF13481.6 KOO27672.1 - 0.0025 17.4 0.2 0.012 15.2 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 KOO27672.1 - 0.0043 16.9 0.0 3.5 7.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KOO27672.1 - 0.0078 16.1 0.2 0.02 14.8 0.1 1.6 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KOO27672.1 - 0.0085 16.5 0.2 0.02 15.3 0.0 1.8 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO27672.1 - 0.013 15.8 0.0 0.14 12.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF503 PF04456.12 KOO27672.1 - 0.039 13.8 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF503) AAA_29 PF13555.6 KOO27672.1 - 0.052 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 KOO27672.1 - 0.053 13.0 0.1 0.98 8.8 0.1 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA PF00004.29 KOO27672.1 - 0.081 13.4 0.0 0.72 10.3 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) IIGP PF05049.13 KOO27672.1 - 0.088 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_18 PF13238.6 KOO27672.1 - 0.11 13.0 0.0 0.19 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 KOO27672.1 - 0.17 11.6 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 KOO27672.1 - 0.17 11.9 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 Dynamin family AAA_33 PF13671.6 KOO27672.1 - 0.18 12.0 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOO27672.1 - 0.23 11.2 0.0 0.5 10.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Pam17 PF08566.10 KOO27672.1 - 0.25 11.2 0.3 0.6 9.9 0.3 1.6 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 TP6A_N PF04406.14 KOO27675.1 - 1.3e-08 34.7 0.0 2.7e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Type IIB DNA topoisomerase EF-hand_1 PF00036.32 KOO27676.1 - 2.8e-10 39.0 0.0 7.3e-05 22.0 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO27676.1 - 1.8e-09 37.9 0.0 2.7e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO27676.1 - 2.3e-09 37.0 0.1 9.6e-09 35.0 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO27676.1 - 4.8e-08 32.1 0.2 0.0065 15.9 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO27676.1 - 8.1e-08 31.6 0.1 0.0022 17.8 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO27676.1 - 0.052 13.5 0.0 0.086 12.8 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO27676.1 - 0.22 11.8 0.0 0.35 11.2 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region GST_C_3 PF14497.6 KOO27677.1 - 1.3e-11 44.5 0.0 2.1e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOO27677.1 - 0.00058 20.2 0.0 0.0016 18.8 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOO27677.1 - 0.00085 19.5 0.0 0.0062 16.7 0.0 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOO27677.1 - 0.0054 16.7 0.0 0.013 15.5 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ras PF00071.22 KOO27678.1 - 1e-64 217.0 0.6 1.2e-64 216.8 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO27678.1 - 6.8e-37 126.3 0.2 1.2e-36 125.6 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO27678.1 - 7.9e-18 64.5 0.2 1e-17 64.1 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KOO27678.1 - 3.7e-07 30.2 0.5 0.026 14.4 0.1 2.5 1 1 2 3 3 3 2 RsgA GTPase SRPRB PF09439.10 KOO27678.1 - 5.7e-06 25.9 1.3 6.8e-06 25.6 0.1 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KOO27678.1 - 1.2e-05 25.3 0.1 2.1e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOO27678.1 - 2.2e-05 24.1 0.9 6.5e-05 22.6 0.3 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KOO27678.1 - 3e-05 23.5 0.1 4.1e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 KOO27678.1 - 0.0014 18.2 0.1 0.01 15.4 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.29 KOO27678.1 - 0.0057 17.1 0.2 0.83 10.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 KOO27678.1 - 0.0097 16.4 0.1 0.016 15.7 0.1 1.6 1 1 0 1 1 1 1 ABC transporter AAA_5 PF07728.14 KOO27678.1 - 0.012 15.6 0.1 0.026 14.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO27678.1 - 0.024 14.9 0.0 0.053 13.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 KOO27678.1 - 0.048 12.9 0.1 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 Septin AAA_16 PF13191.6 KOO27678.1 - 0.091 13.1 0.0 0.17 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 KOO27678.1 - 0.16 11.9 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 KOO27678.1 - 0.18 11.6 0.3 0.48 10.2 0.0 1.9 2 0 0 2 2 1 0 P-loop containing region of AAA domain NCA2 PF08637.10 KOO27679.1 - 7.9e-20 71.2 2.5 5.8e-12 45.4 0.6 2.3 2 0 0 2 2 2 2 ATP synthase regulation protein NCA2 Ank_2 PF12796.7 KOO27679.1 - 2.7e-12 47.1 0.0 2.4e-07 31.2 0.0 3.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO27679.1 - 2.4e-09 37.3 0.9 3.2e-06 27.3 0.2 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO27679.1 - 2.8e-08 34.2 0.0 0.014 15.9 0.1 4.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27679.1 - 7e-06 26.0 2.2 0.0057 17.1 0.1 4.5 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 KOO27679.1 - 0.00034 20.9 0.1 0.00034 20.9 0.1 4.1 5 0 0 5 5 5 1 Ankyrin repeat GIT_CC PF16559.5 KOO27680.1 - 0.25 11.3 1.7 0.75 9.7 1.7 1.8 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor LUC7 PF03194.15 KOO27680.1 - 4.7 6.8 8.7 0.54 9.9 3.8 1.7 2 0 0 2 2 2 0 LUC7 N_terminus BST2 PF16716.5 KOO27680.1 - 7.1 7.3 16.2 0.29 11.7 0.3 3.1 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 5_3_exonuc_N PF02739.16 KOO27681.1 - 4.7e-33 114.3 0.0 6.4e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 KOO27681.1 - 1.8e-26 92.6 0.0 3.1e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold NYN_YacP PF05991.11 KOO27681.1 - 0.007 16.3 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 YacP-like NYN domain HHH_5 PF14520.6 KOO27681.1 - 0.16 12.6 0.0 0.45 11.1 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain Guanylate_kin PF00625.21 KOO27682.1 - 9.1e-62 208.0 0.0 1.2e-61 207.6 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 KOO27682.1 - 7.2e-05 23.0 0.1 0.0014 18.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KOO27682.1 - 7.4e-05 22.7 0.0 0.00012 22.0 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 KOO27682.1 - 0.00026 21.4 0.1 0.00037 20.9 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 KOO27682.1 - 0.0061 16.6 0.0 0.0099 16.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KOO27682.1 - 0.0072 16.6 0.0 0.017 15.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain Methyltransf_12 PF08242.12 KOO27682.1 - 0.033 14.9 0.0 5.6 7.8 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain AAA_7 PF12775.7 KOO27682.1 - 0.038 13.5 0.0 0.065 12.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 KOO27682.1 - 0.067 13.7 1.8 0.56 10.8 1.8 2.2 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOO27682.1 - 0.086 13.4 0.0 0.11 13.0 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Rad17 PF03215.15 KOO27682.1 - 0.14 12.1 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain Roc PF08477.13 KOO27682.1 - 0.16 12.2 0.0 0.62 10.3 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_17 PF13207.6 KOO27682.1 - 0.16 12.3 0.1 0.49 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KOO27682.1 - 0.17 11.8 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 NTPase GTP_EFTU PF00009.27 KOO27682.1 - 0.17 11.4 0.0 3.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 KOO27682.1 - 0.23 11.9 0.0 0.51 10.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Ppx-GppA PF02541.16 KOO27683.1 - 1.2e-12 47.9 0.1 1.9e-12 47.2 0.1 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family Voltage_CLC PF00654.20 KOO27684.1 - 6.1e-66 223.1 13.4 6.1e-66 223.1 13.4 1.9 2 1 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 KOO27684.1 - 4.1e-11 43.2 1.0 1.1e-05 25.8 0.2 4.1 4 0 0 4 4 4 2 CBS domain SNARE_assoc PF09335.11 KOO27684.1 - 9.6e-11 42.2 6.1 9.6e-11 42.2 6.1 3.7 4 0 0 4 4 4 1 SNARE associated Golgi protein BLUF PF04940.12 KOO27684.1 - 0.039 14.1 0.0 0.091 12.9 0.0 1.6 1 0 0 1 1 1 0 Sensors of blue-light using FAD LRR_6 PF13516.6 KOO27685.1 - 8.2e-08 31.7 7.1 5.3e-05 23.0 0.0 4.1 4 0 0 4 4 4 2 Leucine Rich repeat SAP PF02037.27 KOO27685.1 - 2e-06 27.4 0.6 5.5e-06 26.0 0.6 1.8 1 0 0 1 1 1 1 SAP domain GAS2 PF02187.17 KOO27686.1 - 0.00015 21.8 0.2 0.00034 20.6 0.0 1.7 2 0 0 2 2 2 1 Growth-Arrest-Specific Protein 2 Domain DUF3235 PF11574.8 KOO27686.1 - 0.089 13.7 0.2 0.089 13.7 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3235) His_Phos_2 PF00328.22 KOO27689.1 - 1.8e-66 225.1 0.3 4.3e-37 128.4 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 KOO27689.1 - 1.8e-25 88.9 0.0 3.3e-25 88.1 0.0 1.5 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 KOO27689.1 - 0.0086 15.7 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Sulfotransfer_2 PF03567.14 KOO27690.1 - 1.9e-10 41.1 0.0 4e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Sulfotransferase family CDC73_C PF05179.14 KOO27691.1 - 1.8e-31 109.0 0.0 2.9e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 KOO27691.1 - 3.1e-23 82.5 0.0 5.1e-19 68.7 0.0 2.2 2 0 0 2 2 2 2 Paf1 complex subunit CDC73 N-terminal EF-hand_5 PF13202.6 KOO27692.1 - 2.8e-08 32.9 0.9 0.00058 19.2 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 KOO27692.1 - 3.2e-08 32.6 0.0 0.0012 18.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO27692.1 - 5.3e-06 25.9 0.0 0.034 14.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO27692.1 - 4.6e-05 23.2 0.0 0.22 11.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO27692.1 - 0.00027 21.3 0.0 0.0029 18.0 0.0 2.1 1 1 0 1 1 1 1 EF-hand domain pair Dockerin_1 PF00404.18 KOO27692.1 - 0.083 13.1 0.1 8.2 6.7 0.0 2.2 2 0 0 2 2 2 0 Dockerin type I domain MAPEG PF01124.18 KOO27694.1 - 6.6e-06 26.1 0.7 9.5e-06 25.5 0.0 1.7 2 0 0 2 2 2 1 MAPEG family DUF5324 PF17258.2 KOO27694.1 - 0.2 11.3 5.6 0.34 10.6 5.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5324) Vps26 PF03643.15 KOO27695.1 - 4.5e-42 144.0 0.0 6.1e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 KOO27695.1 - 0.00077 19.5 0.0 0.0026 17.8 0.0 1.9 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain DUF4133 PF13571.6 KOO27696.1 - 0.16 12.4 2.5 0.53 10.7 2.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4133) Phage_holin_3_6 PF07332.11 KOO27696.1 - 1.6 8.8 8.0 5.6 7.0 3.3 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Ion_trans PF00520.31 KOO27697.1 - 1.2e-96 322.6 63.1 1.5e-43 148.8 13.0 4.4 5 0 0 5 5 5 4 Ion transport protein Glyco_hydro_127 PF07944.12 KOO27697.1 - 2e-14 53.0 0.0 8.3e-14 51.0 0.0 1.8 1 1 1 2 2 2 1 Beta-L-arabinofuranosidase, GH127 PKD_channel PF08016.12 KOO27697.1 - 2.7e-05 23.1 24.6 7.2e-05 21.6 4.9 5.8 6 0 0 6 6 6 3 Polycystin cation channel EF-hand_1 PF00036.32 KOO27697.1 - 0.019 14.5 0.1 0.062 12.9 0.1 2.0 1 0 0 1 1 1 0 EF hand Ctr PF04145.15 KOO27697.1 - 0.04 14.5 5.9 0.34 11.5 0.0 3.6 3 1 0 3 3 3 0 Ctr copper transporter family Cytotoxic PF09000.10 KOO27697.1 - 0.05 13.9 0.1 0.097 13.0 0.1 1.4 1 0 0 1 1 1 0 Cytotoxic DUF2534 PF10749.9 KOO27697.1 - 0.32 11.2 8.2 4.1 7.6 2.9 3.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2534) MORN PF02493.20 KOO27698.1 - 1.1e-43 144.5 43.8 7.1e-07 28.8 0.4 9.2 9 0 0 9 9 9 8 MORN repeat Trimer_CC PF08954.11 KOO27698.1 - 0.014 14.9 10.7 4.6 6.9 0.2 3.7 2 1 1 3 3 3 0 Trimerisation motif DUF3048_C PF17479.2 KOO27698.1 - 2.1 8.7 12.6 24 5.3 1.4 4.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3048) C-terminal domain P66_CC PF16563.5 KOO27698.1 - 9 6.0 23.1 10 5.8 1.3 3.4 3 0 0 3 3 3 0 Coiled-coil and interaction region of P66A and P66B with MBD2 p25-alpha PF05517.12 KOO27700.1 - 0.00017 21.8 3.3 0.00017 21.8 3.3 9.0 10 0 0 10 10 10 2 p25-alpha DUF4277 PF14104.6 KOO27700.1 - 0.22 11.9 0.3 34 4.9 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4277) Tma16 PF11176.8 KOO27700.1 - 0.25 11.2 1.6 3.1 7.7 0.1 2.8 2 0 0 2 2 2 0 Translation machinery-associated protein 16 CH_2 PF06294.11 KOO27700.1 - 3.6 7.8 11.5 0.38 10.9 0.5 4.0 4 0 0 4 4 4 0 CH-like domain in sperm protein DUF760 PF05542.11 KOO27701.1 - 1.5e-31 108.5 0.8 2.3e-15 56.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF760) 2OG-FeII_Oxy_4 PF13661.6 KOO27702.1 - 1.9e-12 47.7 0.0 3.5e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 KOO27702.1 - 3.5e-10 40.6 0.0 1.1e-09 39.0 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF569 PF04601.13 KOO27702.1 - 0.12 12.1 0.0 0.32 10.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF569) Fe-ADH PF00465.19 KOO27702.1 - 0.12 11.2 0.1 0.15 10.9 0.1 1.1 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase GTP_EFTU PF00009.27 KOO27703.1 - 1.5e-50 171.5 0.4 2.1e-50 171.0 0.4 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KOO27703.1 - 1.9e-20 72.7 0.0 3.5e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 KOO27703.1 - 1.5e-07 31.5 0.2 4.7e-07 29.9 0.2 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 KOO27703.1 - 2.9e-06 27.6 0.1 1.6e-05 25.2 0.0 2.4 3 0 0 3 3 2 1 Elongation factor Tu domain 2 Septin PF00735.18 KOO27703.1 - 5.2e-05 22.7 0.1 8.2e-05 22.0 0.1 1.2 1 0 0 1 1 1 1 Septin FeoB_N PF02421.18 KOO27703.1 - 0.00037 20.0 0.1 0.015 14.8 0.1 2.6 2 1 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 KOO27703.1 - 0.0015 18.0 0.0 0.004 16.6 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 KOO27703.1 - 0.021 14.2 0.1 0.089 12.2 0.1 2.0 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 KOO27703.1 - 0.057 13.5 0.0 4.4 7.3 0.0 2.2 1 1 1 2 2 2 0 Dynamin family EFG_II PF14492.6 KOO27703.1 - 0.075 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Elongation Factor G, domain II Roc PF08477.13 KOO27703.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.6 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase STI1 PF17830.1 KOO27704.1 - 9.8e-09 35.0 9.5 2.8e-08 33.6 9.5 1.8 1 1 0 1 1 1 1 STI1 domain SAP PF02037.27 KOO27704.1 - 2.8e-08 33.3 2.7 5.1e-05 22.9 0.1 2.7 3 0 0 3 3 3 2 SAP domain HeH PF12949.7 KOO27704.1 - 0.022 14.5 0.2 0.36 10.6 0.1 2.4 2 0 0 2 2 2 0 HeH/LEM domain AflR PF08493.10 KOO27704.1 - 0.031 13.7 1.2 0.046 13.2 1.2 1.2 1 0 0 1 1 1 0 Aflatoxin regulatory protein 4HBT PF03061.22 KOO27706.1 - 0.00015 22.1 0.0 0.0003 21.1 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily LRR_6 PF13516.6 KOO27707.1 - 2.6e-31 105.0 49.4 0.00026 20.8 0.3 17.0 18 0 0 18 18 18 8 Leucine Rich repeat Ank_5 PF13857.6 KOO27707.1 - 5.6e-14 52.0 0.1 3.3e-07 30.4 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO27707.1 - 7.8e-14 52.0 1.2 2.4e-06 28.0 0.0 3.7 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO27707.1 - 1.4e-11 44.7 0.0 0.00029 21.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27707.1 - 1.9e-07 30.8 0.1 0.00042 20.5 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 KOO27707.1 - 4.3e-07 30.1 0.7 0.024 15.1 0.0 4.2 3 0 0 3 3 3 2 Ankyrin repeat LRR_4 PF12799.7 KOO27707.1 - 9.1e-07 29.1 13.6 0.28 11.7 0.0 9.4 11 2 0 11 11 11 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO27707.1 - 2.6e-06 27.2 3.8 1.9e+02 3.2 0.0 9.9 12 0 0 12 12 12 0 Leucine Rich Repeat Skp1 PF01466.19 KOO27707.1 - 0.0037 17.3 0.0 0.022 14.9 0.0 2.3 2 0 0 2 2 2 1 Skp1 family, dimerisation domain LRR_8 PF13855.6 KOO27707.1 - 0.7 9.7 20.3 32 4.4 3.2 9.1 11 2 0 11 11 11 0 Leucine rich repeat NYN PF01936.18 KOO27708.1 - 5.5e-11 43.1 0.0 8.2e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 NYN domain PAP_fibrillin PF04755.12 KOO27709.1 - 7.7e-08 32.5 0.0 3.3e-07 30.4 0.0 2.1 2 0 0 2 2 2 1 PAP_fibrillin Antirestrict PF03230.13 KOO27709.1 - 0.15 12.1 1.7 0.4 10.7 1.7 1.7 1 0 0 1 1 1 0 Antirestriction protein TFIIA PF03153.13 KOO27709.1 - 2.8 7.9 7.3 3.5 7.5 7.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3347 PF11827.8 KOO27709.1 - 3.4 7.8 23.2 1.4 9.0 6.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) Het-C PF07217.11 KOO27711.1 - 0.0078 14.8 0.8 0.015 13.9 0.0 1.7 1 1 1 2 2 2 1 Heterokaryon incompatibility protein Het-C DUF1501 PF07394.12 KOO27711.1 - 1.1 8.3 7.1 1.2 8.1 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) TPR_MLP1_2 PF07926.12 KOO27711.1 - 4.7 7.3 19.1 6.4 6.9 19.1 1.1 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Kinesin PF00225.23 KOO27712.1 - 4.1e-81 272.5 0.0 6.2e-81 271.9 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain XRN_M PF17846.1 KOO27712.1 - 2.8e-67 227.6 0.0 4.3e-67 227.0 0.0 1.1 1 0 0 1 1 1 1 Xrn1 helical domain Microtub_bd PF16796.5 KOO27712.1 - 3.7e-19 69.2 0.0 5.7e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Borrelia_P83 PF05262.11 KOO27713.1 - 0.61 8.5 8.4 0.78 8.2 8.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein FUSC PF04632.12 KOO27713.1 - 9.9 4.6 13.8 13 4.2 13.8 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1995 PF09353.10 KOO27714.1 - 6.3e-07 29.6 0.2 7.5e-07 29.4 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) HEAT_EZ PF13513.6 KOO27714.1 - 0.3 11.6 0.2 0.3 11.6 0.2 3.6 4 0 0 4 4 4 0 HEAT-like repeat Dynein_C PF18199.1 KOO27715.1 - 3.4e-48 164.5 0.0 3.7e-48 164.3 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain SUV3_C PF12513.8 KOO27717.1 - 2.2e-12 46.7 0.6 4.8e-12 45.6 0.2 1.8 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 KOO27717.1 - 3.4e-10 40.3 0.0 5.4e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 KOO27717.1 - 1.3e-06 28.2 0.0 3.7e-06 26.7 0.0 1.9 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 COX8 PF02285.15 KOO27718.1 - 0.028 14.3 2.2 4.5 7.2 0.3 2.6 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIII YitT_membrane PF02588.15 KOO27718.1 - 0.07 12.5 5.2 2.7 7.3 0.1 3.0 3 0 0 3 3 3 0 Uncharacterised 5xTM membrane BCR, YitT family COG1284 XRN_M PF17846.1 KOO27719.1 - 1.7e-31 109.6 0.0 2e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 KOO27720.1 - 2.4e-63 213.8 0.0 3.5e-63 213.2 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus LRR_6 PF13516.6 KOO27720.1 - 8.4e-26 87.8 37.2 0.00025 20.8 0.1 15.0 16 0 0 16 16 16 10 Leucine Rich repeat LRR_4 PF12799.7 KOO27720.1 - 7.5e-12 45.3 6.1 1.4 9.4 0.0 8.1 8 1 0 8 8 8 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO27720.1 - 1.5e-06 27.9 0.0 1.5e+02 3.6 0.0 8.7 11 0 0 11 11 11 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO27720.1 - 0.11 12.2 19.9 5 7.0 0.7 7.8 7 5 0 7 7 7 0 Leucine rich repeat PALP PF00291.25 KOO27721.1 - 8.8e-18 64.7 0.7 9.7e-18 64.6 0.7 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M1_N PF17900.1 KOO27722.1 - 5.8e-17 62.5 0.0 7.9e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 KOO27722.1 - 8.7e-09 35.3 0.1 1.2e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain TPR_19 PF14559.6 KOO27723.1 - 9.2e-11 42.1 15.4 0.0011 19.5 3.8 5.9 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27723.1 - 3.2e-10 40.5 11.0 0.0067 17.1 0.0 6.1 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO27723.1 - 2.7e-09 37.2 15.8 2.4 8.5 0.2 8.6 7 3 1 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27723.1 - 5.7e-09 35.4 30.4 0.031 14.4 0.2 10.6 11 0 0 11 11 11 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO27723.1 - 6.2e-08 32.8 23.8 0.045 14.0 0.8 5.9 5 1 1 6 6 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 KOO27723.1 - 3.6e-07 29.7 30.6 0.14 12.0 0.6 9.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 KOO27723.1 - 0.00025 20.9 12.9 2.4 8.4 0.2 7.2 9 0 0 9 9 8 2 Tetratricopeptide repeat Sec16_C PF12931.7 KOO27723.1 - 0.001 18.8 1.3 0.0022 17.7 1.3 1.5 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 TPR_18 PF13512.6 KOO27723.1 - 0.011 15.9 4.6 0.013 15.6 2.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO27723.1 - 0.028 15.2 13.3 6.3 7.9 0.2 7.5 6 2 3 9 9 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27723.1 - 0.043 14.0 20.6 2.6 8.5 0.4 7.7 9 0 0 9 9 9 0 Tetratricopeptide repeat Rubrerythrin PF02915.17 KOO27723.1 - 0.044 14.2 3.7 0.35 11.3 1.1 3.1 3 0 0 3 3 3 0 Rubrerythrin HrpB1_HrpK PF09613.10 KOO27723.1 - 0.045 13.4 6.1 3.2 7.4 0.0 4.5 4 2 1 5 5 5 0 Bacterial type III secretion protein (HrpB1_HrpK) NAD_binding_10 PF13460.6 KOO27724.1 - 9.4e-06 25.6 0.2 0.002 18.1 0.2 2.7 1 1 0 1 1 1 1 NAD(P)H-binding IFR3_antag PF14754.6 KOO27724.1 - 0.059 12.6 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Papain-like auto-proteinase DUF5333 PF17267.2 KOO27724.1 - 0.59 10.3 4.5 2.1 8.6 0.7 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5333) Tho2 PF11262.8 KOO27724.1 - 1 8.5 4.5 1.5 7.9 4.5 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Coilin_N PF15862.5 KOO27724.1 - 3.3 7.5 7.8 31 4.4 7.1 2.1 2 0 0 2 2 2 0 Coilin N-terminus VPS13_C PF16909.5 KOO27726.1 - 1.9e-29 102.7 0.1 1.4e-28 99.9 0.0 2.3 3 0 0 3 3 3 1 Vacuolar-sorting-associated 13 protein C-terminal Ank_5 PF13857.6 KOO27726.1 - 1.6e-14 53.7 3.0 3.9e-07 30.2 0.3 3.7 3 1 2 5 5 5 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO27726.1 - 5.1e-13 49.4 0.7 1e-06 29.2 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO27726.1 - 4e-12 46.4 1.7 0.0011 19.5 0.0 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO27726.1 - 1.5e-09 37.9 11.4 0.00047 20.5 0.1 6.0 6 0 0 6 6 6 2 Ankyrin repeat Ank_3 PF13606.6 KOO27726.1 - 8.7e-09 34.9 3.6 0.064 13.8 0.1 5.5 5 0 0 5 5 5 2 Ankyrin repeat Adaptin_N PF01602.20 KOO27728.1 - 4.9e-102 342.2 3.1 6e-102 341.9 3.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KOO27728.1 - 5.2e-45 153.4 5.2 9.7e-43 146.0 1.7 2.9 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOO27728.1 - 7.1e-12 45.6 7.6 0.00016 22.0 0.1 6.0 3 2 5 8 8 8 4 HEAT repeats HEAT PF02985.22 KOO27728.1 - 3.4e-11 42.4 1.2 0.2 12.0 0.0 5.5 5 0 0 5 5 5 3 HEAT repeat RTP1_C1 PF10363.9 KOO27728.1 - 0.00061 19.9 4.4 0.084 13.1 0.1 4.1 3 2 2 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 KOO27728.1 - 0.0018 18.7 6.0 2.1 8.9 0.0 6.1 7 0 0 7 7 7 1 HEAT-like repeat CLASP_N PF12348.8 KOO27728.1 - 0.059 12.9 0.2 1.3 8.5 0.0 3.0 2 1 1 3 3 3 0 CLASP N terminal API5 PF05918.11 KOO27728.1 - 0.069 12.0 0.0 0.21 10.4 0.0 1.7 1 1 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Arm PF00514.23 KOO27728.1 - 0.23 11.5 0.9 1.4 9.0 0.1 2.7 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat XRN_M PF17846.1 KOO27730.1 - 7.8e-120 400.8 0.0 3.6e-119 398.6 0.0 2.0 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 KOO27730.1 - 6.2e-88 294.3 0.0 1.1e-87 293.5 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus Pro_isomerase PF00160.21 KOO27731.1 - 2.1e-47 161.3 0.0 2.4e-47 161.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cystatin PF00031.21 KOO27732.1 - 0.92 9.8 4.9 0.28 11.5 1.0 2.2 2 0 0 2 2 2 0 Cystatin domain DUF1018 PF06252.12 KOO27734.1 - 0.015 16.3 0.3 1.2 10.2 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) PDZ PF00595.24 KOO27736.1 - 5.5e-13 49.1 0.0 1.3e-07 31.9 0.0 2.4 2 0 0 2 2 2 2 PDZ domain WW PF00397.26 KOO27736.1 - 2.8e-08 33.7 3.2 8.4e-06 25.8 0.0 2.8 3 0 0 3 3 3 2 WW domain PDZ_2 PF13180.6 KOO27736.1 - 4.5e-08 33.3 0.0 2.4e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KOO27736.1 - 3.3e-07 30.0 0.6 0.00017 21.3 0.2 2.7 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 KOO27736.1 - 0.00031 20.6 0.0 0.35 10.9 0.0 2.4 2 0 0 2 2 2 2 Tricorn protease PDZ domain DnaJ PF00226.31 KOO27737.1 - 2.1e-15 56.6 0.3 3.4e-14 52.7 0.3 2.7 1 1 0 1 1 1 1 DnaJ domain Myb_DNA-binding PF00249.31 KOO27737.1 - 1.6e-12 47.4 3.9 7e-08 32.5 0.4 2.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO27737.1 - 2.1e-06 27.9 0.0 0.015 15.6 0.0 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain zf-C3H2C3 PF17122.5 KOO27738.1 - 4.5e-06 26.6 12.9 8.4e-06 25.7 12.9 1.5 1 0 0 1 1 1 1 Zinc-finger VPS11_C PF12451.8 KOO27738.1 - 1e-05 25.6 0.2 1.8e-05 24.9 0.2 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal Clathrin PF00637.20 KOO27738.1 - 0.0037 17.1 0.0 0.023 14.6 0.0 2.1 2 0 0 2 2 2 1 Region in Clathrin and VPS HTH_18 PF12833.7 KOO27738.1 - 0.026 14.8 0.2 0.13 12.5 0.2 2.2 1 0 0 1 1 1 0 Helix-turn-helix domain zf-C3HC4_2 PF13923.6 KOO27738.1 - 0.033 14.0 10.7 0.064 13.1 10.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO27738.1 - 0.066 13.6 9.9 0.15 12.4 9.9 1.7 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 KOO27738.1 - 0.33 11.0 8.4 0.74 9.9 8.4 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 KOO27738.1 - 0.33 11.0 8.5 0.87 9.6 8.5 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 KOO27738.1 - 1.9 8.9 10.1 4 7.8 10.1 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOO27738.1 - 2.3 8.2 9.0 5.1 7.1 9.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Lipase_GDSL_2 PF13472.6 KOO27740.1 - 0.082 13.3 0.0 0.41 11.0 0.0 2.1 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Chorismate_synt PF01264.21 KOO27741.1 - 1e-130 435.3 0.0 3.7e-130 433.4 0.0 1.7 1 1 0 1 1 1 1 Chorismate synthase MORN PF02493.20 KOO27742.1 - 5.7e-12 44.8 13.0 9.1e-07 28.4 1.7 3.7 3 0 0 3 3 3 3 MORN repeat LRR_6 PF13516.6 KOO27742.1 - 2.6e-05 23.9 0.8 0.026 14.6 0.0 3.3 4 0 0 4 4 4 2 Leucine Rich repeat YabA PF06156.13 KOO27742.1 - 0.17 12.6 1.4 0.54 10.9 1.4 1.8 1 0 0 1 1 1 0 Initiation control protein YabA Fungal_TACC PF12709.7 KOO27742.1 - 0.25 11.8 0.9 0.51 10.8 0.9 1.4 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins TFIIA PF03153.13 KOO27742.1 - 2.1 8.2 9.0 3.1 7.7 9.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 KOO27745.1 - 6e-129 431.2 0.4 1.8e-99 333.8 0.3 3.0 1 1 1 2 2 2 2 CDC45-like protein Sld5 PF05916.11 KOO27746.1 - 1.9e-19 70.1 0.1 2.8e-19 69.6 0.1 1.3 1 0 0 1 1 1 1 GINS complex protein PLDc_2 PF13091.6 KOO27747.1 - 1e-24 86.9 0.0 6.8e-14 51.9 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc_3 PF13918.6 KOO27747.1 - 1.5e-15 57.3 0.0 6.1e-14 52.1 0.0 2.7 3 0 0 3 3 3 1 PLD-like domain PLDc PF00614.22 KOO27747.1 - 4.4e-06 26.7 1.3 0.0016 18.6 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif Ndufs5 PF10200.9 KOO27749.1 - 0.038 14.2 0.2 0.089 13.1 0.2 1.6 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa MMR_HSR1 PF01926.23 KOO27750.1 - 4.7e-20 71.8 0.0 7.3e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.22 KOO27750.1 - 1.3e-15 57.3 5.4 5.8e-07 29.2 1.2 2.8 2 2 0 2 2 2 2 GTP1/OBG GTP_EFTU PF00009.27 KOO27750.1 - 0.00011 21.8 0.0 0.059 12.9 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOO27750.1 - 0.00015 21.3 0.0 0.0029 17.1 0.0 2.7 2 1 1 3 3 3 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOO27750.1 - 0.0017 18.4 0.0 0.44 10.6 0.0 2.3 1 1 1 2 2 2 2 Dynamin family ATP_bind_1 PF03029.17 KOO27750.1 - 0.01 15.7 0.0 0.75 9.5 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 KOO27750.1 - 0.077 12.0 0.1 0.97 8.4 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 KOO27750.1 - 0.2 11.1 0.0 23 4.4 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family ScsC_N PF18312.1 KOO27751.1 - 0.1 12.4 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain IQ PF00612.27 KOO27752.1 - 0.0073 16.0 0.2 0.0073 16.0 0.2 2.0 2 0 0 2 2 2 1 IQ calmodulin-binding motif HALZ PF02183.18 KOO27752.1 - 0.12 12.6 2.1 0.53 10.6 2.1 2.1 1 1 0 1 1 1 0 Homeobox associated leucine zipper AAA_23 PF13476.6 KOO27752.1 - 0.94 9.9 3.5 1.3 9.5 3.5 1.3 1 0 0 1 1 1 0 AAA domain Cep57_CLD_2 PF14197.6 KOO27752.1 - 3.2 7.9 10.5 2.2 8.4 4.7 3.0 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 Atg14 PF10186.9 KOO27752.1 - 3.7 6.5 8.0 13 4.8 6.5 2.2 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Redoxin PF08534.10 KOO27753.1 - 3e-05 23.8 0.0 4.3e-05 23.3 0.0 1.4 1 1 0 1 1 1 1 Redoxin Nuc_sug_transp PF04142.15 KOO27754.1 - 1.6e-23 83.3 6.4 1.8e-23 83.2 6.4 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO27754.1 - 0.001 19.2 4.9 0.001 19.2 4.9 2.4 2 0 0 2 2 2 1 EamA-like transporter family Fez1 PF06818.15 KOO27755.1 - 0.6 10.5 32.9 0.15 12.5 12.2 3.1 2 1 1 3 3 3 0 Fez1 DASH_Dad4 PF08650.10 KOO27755.1 - 0.83 9.7 3.9 2.6 8.1 0.3 2.9 3 0 0 3 3 3 0 DASH complex subunit Dad4 WD40 PF00400.32 KOO27756.1 - 6.2e-18 64.8 4.5 0.0027 18.5 0.2 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO27756.1 - 7e-08 32.7 0.2 0.37 11.1 0.0 5.3 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO27756.1 - 0.056 12.4 0.0 0.63 8.9 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein MFS_1 PF07690.16 KOO27758.1 - 1.3e-33 116.4 33.8 1.3e-33 116.4 33.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SAS-6_N PF16531.5 KOO27759.1 - 2.5e-26 92.1 0.0 3.7e-26 91.5 0.0 1.3 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal PA28_beta PF02252.18 KOO27760.1 - 1e-27 96.6 0.5 5.9e-16 58.5 0.1 2.1 1 1 1 2 2 2 2 Proteasome activator pa28 beta subunit Tir_receptor_N PF07490.11 KOO27760.1 - 0.0016 18.3 1.4 0.003 17.4 1.4 1.4 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) N-terminus DUF3467 PF11950.8 KOO27760.1 - 0.046 13.9 0.2 2.2 8.5 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3467) POX PF07526.11 KOO27760.1 - 0.33 11.5 5.9 0.13 12.9 3.3 1.7 2 0 0 2 2 2 0 Associated with HOX Pox_RNA_Pol_19 PF05320.12 KOO27760.1 - 0.81 9.6 5.4 1.2 9.1 4.0 1.8 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF1980 PF09323.10 KOO27760.1 - 1.6 8.6 4.0 2.4 8.0 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) LSDAT_euk PF18139.1 KOO27761.1 - 1.3e-52 178.8 0.0 2.4e-52 178.0 0.0 1.4 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 KOO27761.1 - 1.6e-22 79.7 0.3 6.7e-22 77.7 0.3 1.9 1 1 0 1 1 1 1 SLOG in TRPM, prokaryote LDcluster4 PF18306.1 KOO27761.1 - 0.00082 19.0 0.5 0.16 11.5 0.0 2.3 2 0 0 2 2 2 2 SLOG cluster4 family Ion_trans PF00520.31 KOO27762.1 - 5.9e-11 42.1 17.9 9.9e-11 41.3 17.9 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO27762.1 - 4.1e-06 25.8 9.3 6.6e-06 25.1 9.3 1.3 1 0 0 1 1 1 1 Polycystin cation channel EF-hand_6 PF13405.6 KOO27762.1 - 0.003 17.4 0.1 0.014 15.3 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO27762.1 - 0.0032 16.9 0.0 0.011 15.2 0.0 2.0 2 0 0 2 2 2 1 EF hand PHINT_rpt PF14882.6 KOO27762.1 - 0.13 12.5 0.5 2.7 8.3 0.1 2.4 2 0 0 2 2 2 0 Phage-integrase repeat unit ADH_zinc_N_2 PF13602.6 KOO27763.1 - 3.4e-25 89.6 0.0 6.5e-25 88.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOO27763.1 - 5.7e-14 52.2 0.1 1.5e-13 50.8 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOO27763.1 - 9.3e-07 28.7 0.5 1.6e-05 24.7 0.2 2.7 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 KOO27763.1 - 0.021 14.1 2.4 0.04 13.2 2.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 KOO27763.1 - 0.077 12.7 0.8 0.17 11.6 0.5 1.4 1 1 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase EF-hand_1 PF00036.32 KOO27765.1 - 2.2e-08 33.1 0.1 0.00023 20.5 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO27765.1 - 3.8e-06 26.4 0.1 0.019 14.9 0.1 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO27765.1 - 1.3e-05 24.9 0.1 0.048 13.5 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO27765.1 - 1.7e-05 24.1 0.1 0.023 14.2 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO27765.1 - 4.1e-05 23.9 0.1 6.9e-05 23.2 0.1 1.4 1 1 0 1 1 1 1 EF-hand domain pair DUF1180 PF06679.12 KOO27767.1 - 0.08 13.4 3.1 0.15 12.5 3.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Syndecan PF01034.20 KOO27767.1 - 0.21 11.5 0.1 0.21 11.5 0.1 1.9 2 0 0 2 2 2 0 Syndecan domain Chon_Sulph_att PF06566.11 KOO27767.1 - 0.27 11.1 1.8 0.34 10.8 1.8 1.1 1 0 0 1 1 1 0 Chondroitin sulphate attachment domain DUF2613 PF11021.8 KOO27767.1 - 0.93 9.6 0.0 0.93 9.6 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2613) LYRIC PF15686.5 KOO27768.1 - 0.028 14.0 0.8 0.028 14.0 0.8 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family GHL15 PF14885.6 KOO27769.1 - 0.00047 20.2 0.0 0.0026 17.7 0.0 2.1 1 1 0 1 1 1 1 Hypothetical glycosyl hydrolase family 15 PABP PF00658.18 KOO27770.1 - 2.5e-14 53.2 0.0 4.9e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RNA_GG_bind PF10258.9 KOO27770.1 - 2.7e-12 46.5 0.0 5.1e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 PHAX RNA-binding domain Phage_holin_7_1 PF16081.5 KOO27770.1 - 0.054 13.7 0.2 0.11 12.7 0.2 1.5 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Glutaredoxin PF00462.24 KOO27771.1 - 2e-05 24.7 0.0 4.5e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin Gly_transf_sug PF04488.15 KOO27772.1 - 5.4e-15 55.8 0.0 7.6e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 KOO27772.1 - 0.0011 18.4 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Tetraspanin PF00335.20 KOO27775.1 - 0.00017 21.4 3.2 0.00017 21.4 3.2 3.6 1 1 2 3 3 3 2 Tetraspanin family MLANA PF14991.6 KOO27775.1 - 0.078 13.3 0.1 0.66 10.3 0.0 2.4 2 0 0 2 2 2 0 Protein melan-A DUF3981 PF13139.6 KOO27775.1 - 0.15 12.5 1.8 0.5 10.7 1.8 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3981) Clat_adaptor_s PF01217.20 KOO27776.1 - 9.1e-48 161.8 2.2 1e-47 161.6 2.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain HOCHOB PF17943.1 KOO27776.1 - 0.13 13.0 1.3 1.1 10.0 0.7 2.5 2 1 0 2 2 2 0 Homeobox-cysteine loop-homeobox SBBP PF06739.11 KOO27777.1 - 3.5e-10 39.7 33.1 0.003 17.5 0.5 6.3 6 0 0 6 6 6 5 Beta-propeller repeat Trypsin_2 PF13365.6 KOO27777.1 - 1e-05 26.5 1.4 0.0001 23.2 1.4 2.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain SBBP PF06739.11 KOO27778.1 - 2.5e-12 46.6 34.0 0.0013 18.7 0.6 6.1 6 0 0 6 6 6 5 Beta-propeller repeat Keratin_2_head PF16208.5 KOO27778.1 - 0.89 9.7 56.6 1.5 9.0 12.7 4.3 1 1 3 4 4 4 0 Keratin type II head UTP25 PF06862.12 KOO27781.1 - 2.3e-41 142.1 0.0 2.4e-41 142.0 0.0 1.0 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 RNase_Zc3h12a PF11977.8 KOO27782.1 - 0.0081 15.9 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain PRORP PF16953.5 KOO27782.1 - 0.16 11.5 0.0 0.2 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein-only RNase P Ion_trans_2 PF07885.16 KOO27784.1 - 1.3e-21 76.3 15.6 7.6e-11 41.8 8.3 2.3 2 0 0 2 2 2 2 Ion channel DUF21 PF01595.20 KOO27784.1 - 0.0016 18.2 1.6 0.0032 17.2 1.6 1.5 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain Ion_trans PF00520.31 KOO27784.1 - 0.0058 15.9 7.3 0.031 13.5 2.0 2.2 2 0 0 2 2 2 2 Ion transport protein YGGT PF02325.17 KOO27784.1 - 0.015 15.7 0.2 0.036 14.5 0.2 1.6 1 0 0 1 1 1 0 YGGT family EF-hand_1 PF00036.32 KOO27784.1 - 0.021 14.4 1.4 0.041 13.4 0.1 2.2 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 KOO27784.1 - 0.03 14.8 0.0 0.13 12.8 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 KOO27784.1 - 0.033 13.7 0.1 0.075 12.6 0.1 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 KOO27784.1 - 0.2 11.6 1.9 0.23 11.5 0.1 2.0 2 0 0 2 2 2 0 EF-hand domain GPI2 PF06432.11 KOO27784.1 - 0.78 9.1 3.8 1.3 8.4 3.8 1.3 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase LSDAT_euk PF18139.1 KOO27789.1 - 1.8e-41 142.3 0.2 4.9e-21 75.3 0.0 2.2 2 0 0 2 2 2 2 SLOG in TRPM Orn_Arg_deC_N PF02784.16 KOO27789.1 - 2.1e-34 119.0 0.0 3.3e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain LSDAT_prok PF18171.1 KOO27789.1 - 1.6e-24 86.3 0.1 8.6e-14 51.2 0.1 2.6 2 0 0 2 2 2 2 SLOG in TRPM, prokaryote NUDIX PF00293.28 KOO27789.1 - 3.3e-08 33.6 0.0 1.1e-07 32.0 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain LDcluster4 PF18306.1 KOO27789.1 - 0.0066 16.1 0.4 3.1 7.4 0.0 2.3 2 0 0 2 2 2 2 SLOG cluster4 family Terminase_6C PF17289.2 KOO27789.1 - 0.14 12.2 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Terminase RNaseH-like domain Peptidase_S41 PF03572.18 KOO27789.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S41 Arm PF00514.23 KOO27790.1 - 0.0052 16.8 1.6 2.4 8.3 0.1 3.5 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Exo_endo_phos PF03372.23 KOO27792.1 - 7e-10 38.8 0.0 1.5e-09 37.7 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family C2 PF00168.30 KOO27792.1 - 0.16 12.3 0.0 13 6.2 0.0 2.4 2 0 0 2 2 2 0 C2 domain Gelsolin PF00626.22 KOO27793.1 - 6e-93 304.8 0.0 7e-19 67.5 0.0 6.3 6 0 0 6 6 6 6 Gelsolin repeat VHP PF02209.19 KOO27793.1 - 3.7e-10 39.7 0.4 7.4e-10 38.7 0.4 1.5 1 0 0 1 1 1 1 Villin headpiece domain Na_Ca_ex PF01699.24 KOO27794.1 - 1.6e-08 34.6 10.2 2e-08 34.3 10.2 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein zf-RanBP PF00641.18 KOO27795.1 - 1.3e-08 34.0 0.9 2.5e-08 33.1 0.9 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others MFS_1 PF07690.16 KOO27796.1 - 3.2e-33 115.1 34.3 6.6e-33 114.1 31.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO27796.1 - 0.0049 15.8 16.5 0.01 14.7 16.5 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter polyprenyl_synt PF00348.17 KOO27798.1 - 3.8e-65 219.5 0.1 8.6e-65 218.3 0.0 1.5 2 0 0 2 2 2 1 Polyprenyl synthetase ATP_bind_1 PF03029.17 KOO27798.1 - 3.9e-55 187.3 0.0 1.1e-41 143.2 0.0 2.4 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein MeaB PF03308.16 KOO27798.1 - 0.00091 18.3 0.0 0.0016 17.5 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 KOO27798.1 - 0.0015 18.3 0.4 0.0065 16.2 0.0 2.2 3 0 0 3 3 3 1 AAA domain CbiA PF01656.23 KOO27798.1 - 0.0071 16.4 0.0 0.016 15.2 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain KTI12 PF08433.10 KOO27798.1 - 0.0082 15.6 0.0 0.11 11.9 0.0 2.2 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_31 PF13614.6 KOO27798.1 - 0.018 15.0 0.0 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KOO27798.1 - 0.029 14.5 0.0 0.56 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KOO27798.1 - 0.059 13.6 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KOO27798.1 - 0.11 12.9 0.2 0.28 11.6 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOO27798.1 - 0.19 11.4 0.0 0.4 10.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 KOO27800.1 - 2.2e-37 126.4 31.4 2.5e-06 28.1 0.0 13.1 14 0 0 14 14 14 8 WD domain, G-beta repeat Inhibitor_I78 PF11720.8 KOO27800.1 - 0.086 12.9 0.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Peptidase inhibitor I78 family KH_6 PF15985.5 KOO27800.1 - 0.14 12.5 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 KH domain SET PF00856.28 KOO27801.1 - 2.7e-05 24.6 0.0 4.1e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 SET domain Arm PF00514.23 KOO27802.1 - 8.9e-30 101.8 67.0 0.0005 20.0 0.1 15.3 16 1 1 17 17 16 8 Armadillo/beta-catenin-like repeat EF-hand_6 PF13405.6 KOO27802.1 - 3.1e-08 32.9 0.9 2.7e-05 23.7 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO27802.1 - 5.1e-07 28.8 2.8 9.9e-06 24.8 0.0 2.8 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 KOO27802.1 - 1.3e-05 24.5 0.5 1.3e-05 24.5 0.5 2.9 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 KOO27802.1 - 6.3e-05 23.3 0.0 0.00031 21.1 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair HEAT_2 PF13646.6 KOO27802.1 - 0.00014 22.2 90.1 0.0014 19.0 3.6 11.7 8 4 4 12 12 12 6 HEAT repeats V-ATPase_H_N PF03224.14 KOO27802.1 - 0.00025 20.4 0.0 2.3 7.4 0.0 4.8 6 0 0 6 6 6 1 V-ATPase subunit H HEAT PF02985.22 KOO27802.1 - 0.0011 19.1 4.6 0.021 15.0 0.9 10.6 14 0 0 14 14 10 5 HEAT repeat EF-hand_8 PF13833.6 KOO27802.1 - 0.0011 18.7 0.0 0.0042 16.9 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair Arm_2 PF04826.13 KOO27802.1 - 0.026 14.0 0.1 6.9 6.1 0.0 3.9 4 1 1 5 5 5 0 Armadillo-like WAPL PF07814.13 KOO27802.1 - 0.65 8.7 5.6 0.67 8.7 0.0 3.5 4 1 1 5 5 5 0 Wings apart-like protein regulation of heterochromatin CLASP_N PF12348.8 KOO27802.1 - 0.91 9.0 7.3 0.17 11.4 0.2 2.8 4 0 0 4 4 4 0 CLASP N terminal UNC45-central PF11701.8 KOO27802.1 - 1.3 8.9 14.6 1.6 8.6 0.1 5.5 6 1 0 6 6 6 0 Myosin-binding striated muscle assembly central PseudoU_synth_1 PF01416.20 KOO27805.1 - 1.7e-14 54.2 0.0 3.5e-09 37.1 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase Rnk_N PF14760.6 KOO27805.1 - 0.028 14.9 2.3 0.87 10.1 0.1 2.7 2 0 0 2 2 2 0 Rnk N-terminus UVR PF02151.19 KOO27805.1 - 0.059 13.1 0.3 0.16 11.8 0.3 1.7 1 0 0 1 1 1 0 UvrB/uvrC motif ACC_central PF08326.12 KOO27806.1 - 1.4e-17 63.3 0.1 1.9e-17 62.8 0.1 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Biotin_lipoyl PF00364.22 KOO27806.1 - 4.8e-06 26.3 0.4 1.5e-05 24.7 0.4 1.8 1 1 0 1 1 1 1 Biotin-requiring enzyme EF-hand_1 PF00036.32 KOO27807.1 - 1.4e-18 65.0 0.3 2.8e-05 23.3 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO27807.1 - 4.1e-17 60.6 0.0 0.0014 18.4 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO27807.1 - 1.7e-12 47.6 1.2 4.2e-05 23.9 0.1 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO27807.1 - 8.7e-12 44.0 1.9 0.005 16.3 0.0 3.8 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO27807.1 - 3e-05 23.8 1.4 0.39 10.6 0.3 3.8 3 1 0 3 3 3 2 EF-hand domain pair MPS2 PF17060.5 KOO27807.1 - 0.19 10.9 0.0 0.3 10.3 0.0 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 ATP-synt_D PF01813.17 KOO27808.1 - 0.12 12.2 1.0 0.21 11.4 1.0 1.3 1 0 0 1 1 1 0 ATP synthase subunit D MPC PF03650.13 KOO27809.1 - 1.4e-38 131.4 0.1 4e-18 65.6 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial pyruvate carriers Filamin PF00630.19 KOO27811.1 - 5.4e-23 81.8 0.0 5.4e-08 33.6 0.0 5.0 4 1 1 5 5 5 3 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO27811.1 - 2.2e-06 27.9 4.6 0.0088 16.3 0.0 5.3 6 0 0 6 6 6 1 Invasin, domain 3 Big_1 PF02369.16 KOO27811.1 - 0.00022 21.2 2.5 4.3 7.4 0.1 4.6 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 1) Filamin PF00630.19 KOO27812.1 - 2.8e-10 40.9 0.0 6.3e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO27812.1 - 4.2e-05 23.8 0.0 8.6e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Invasin, domain 3 Big_6 PF17936.1 KOO27812.1 - 0.067 13.5 0.2 0.73 10.1 0.2 2.5 1 1 1 2 2 2 0 Bacterial Ig domain DUF5060 PF16586.5 KOO27812.1 - 0.087 13.2 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5060) AAA_34 PF13872.6 KOO27813.1 - 7.6e-104 346.8 0.0 1.3e-103 346.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 KOO27813.1 - 1.8e-69 234.5 0.4 2.9e-69 233.8 0.4 1.3 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.15 KOO27813.1 - 0.0007 19.6 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf_Rg PF17915.1 KOO27813.1 - 0.059 12.8 0.6 0.45 9.9 0.0 2.6 2 0 0 2 2 2 0 Reverse gyrase zinc finger Zn-ribbon_8 PF09723.10 KOO27813.1 - 0.36 11.0 8.2 3.7 7.7 1.2 2.9 2 0 0 2 2 2 0 Zinc ribbon domain cNMP_binding PF00027.29 KOO27815.1 - 5.9e-34 116.0 0.2 1.3e-20 73.3 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 KOO27815.1 - 0.2 11.4 0.6 0.81 9.4 0.2 2.1 2 0 0 2 2 2 0 Cupin domain DUF4449 PF14613.6 KOO27816.1 - 0.0095 16.1 1.8 0.021 14.9 1.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) FAM76 PF16046.5 KOO27816.1 - 0.01 15.2 2.5 0.011 15.1 1.1 1.5 1 1 1 2 2 2 0 FAM76 protein ABC_tran_CTD PF16326.5 KOO27816.1 - 0.021 15.1 8.7 0.021 15.1 8.7 2.8 2 0 0 2 2 2 0 ABC transporter C-terminal domain FlxA PF14282.6 KOO27816.1 - 0.042 13.8 3.1 0.098 12.7 3.1 1.6 1 0 0 1 1 1 0 FlxA-like protein NuA4 PF09340.10 KOO27816.1 - 0.068 13.1 0.4 0.32 10.9 0.0 2.2 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 YAcAr PF10686.9 KOO27816.1 - 0.082 12.9 1.0 0.42 10.6 1.0 2.3 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family DUF4061 PF13270.6 KOO27816.1 - 0.6 10.5 9.8 1.7 9.0 2.3 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4061) Spc7 PF08317.11 KOO27816.1 - 2.5 6.9 14.6 0.031 13.2 6.5 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein NUC153 PF08159.12 KOO27817.1 - 1.2e-14 53.7 14.2 4.6e-11 42.3 0.6 3.5 3 0 0 3 3 3 3 NUC153 domain DUF3040 PF11239.8 KOO27817.1 - 1.1 9.6 7.8 0.91 9.8 0.2 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3040) DnaJ_C PF01556.18 KOO27818.1 - 3.6e-24 85.5 0.0 4.1e-24 85.4 0.0 1.0 1 0 0 1 1 1 1 DnaJ C terminal domain AAA_18 PF13238.6 KOO27819.1 - 5.7e-22 78.7 0.0 9.1e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOO27819.1 - 9.7e-06 26.0 0.2 4e-05 24.1 0.0 2.0 1 1 1 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 KOO27819.1 - 0.00018 21.0 0.4 0.00063 19.2 0.0 2.0 2 1 1 3 3 3 1 FtsK/SpoIIIE family AAA_28 PF13521.6 KOO27819.1 - 0.00021 21.6 0.1 0.0082 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO27819.1 - 0.00024 21.3 0.2 0.0014 18.8 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 KOO27819.1 - 0.00031 21.2 0.0 0.0019 18.7 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 KOO27819.1 - 0.00071 19.5 0.1 0.0041 17.0 0.0 2.0 2 0 0 2 2 2 1 NTPase AAA_16 PF13191.6 KOO27819.1 - 0.00099 19.5 0.6 0.0023 18.3 0.6 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO27819.1 - 0.0016 18.7 0.3 0.0069 16.7 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KOO27819.1 - 0.0037 17.0 0.4 0.033 13.9 0.1 2.4 2 2 1 3 3 3 1 AAA domain MeaB PF03308.16 KOO27819.1 - 0.0051 15.8 0.2 0.011 14.8 0.1 1.6 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 KOO27819.1 - 0.016 14.4 0.0 0.021 14.1 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) KTI12 PF08433.10 KOO27819.1 - 0.018 14.5 0.0 0.06 12.8 0.0 1.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_32 PF13654.6 KOO27819.1 - 0.022 13.6 0.4 0.83 8.4 0.0 2.4 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 KOO27819.1 - 0.024 14.5 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DUF815 PF05673.13 KOO27819.1 - 0.025 13.8 0.0 0.035 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ADK PF00406.22 KOO27819.1 - 0.028 14.5 0.0 0.33 11.0 0.0 2.1 2 0 0 2 2 2 0 Adenylate kinase AAA_19 PF13245.6 KOO27819.1 - 0.033 14.5 0.9 0.054 13.8 0.9 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO27819.1 - 0.048 13.4 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KOO27819.1 - 0.058 13.5 0.1 0.22 11.6 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 KOO27819.1 - 0.067 13.6 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ATPase PF06745.13 KOO27819.1 - 0.07 12.5 0.1 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 KaiC TrwB_AAD_bind PF10412.9 KOO27819.1 - 0.072 12.0 0.0 0.19 10.6 0.0 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_5 PF07728.14 KOO27819.1 - 0.072 13.1 0.1 0.16 12.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) cobW PF02492.19 KOO27819.1 - 0.1 12.2 0.1 0.25 10.9 0.1 1.7 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 KOO27819.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Mg_chelatase PF01078.21 KOO27819.1 - 0.13 11.6 0.0 0.32 10.4 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI UCMA PF17085.5 KOO27819.1 - 0.14 12.2 1.5 0.14 12.2 0.2 1.6 2 0 0 2 2 2 0 Unique cartilage matrix associated protein AAA_30 PF13604.6 KOO27819.1 - 0.17 11.6 0.8 0.7 9.6 0.3 1.9 1 1 1 2 2 2 0 AAA domain DUF87 PF01935.17 KOO27819.1 - 0.27 11.3 1.3 1.4 9.0 0.1 2.2 1 1 1 2 2 2 0 Helicase HerA, central domain Na_H_Exchanger PF00999.21 KOO27821.1 - 1.4e-42 145.9 42.9 1.9e-42 145.4 42.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 KOO27821.1 - 4.5e-20 72.0 0.0 9.5e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain EF-hand_5 PF13202.6 KOO27821.1 - 3.5e-13 48.4 0.5 1.6e-05 24.1 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO27821.1 - 1.4e-12 46.5 0.1 0.00012 21.7 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO27821.1 - 1.9e-11 44.2 0.3 2e-08 34.6 0.1 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO27821.1 - 1.4e-10 39.9 0.1 0.00032 20.0 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO27821.1 - 1.9e-07 30.8 0.5 0.0076 16.1 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair COPIIcoated_ERV PF07970.12 KOO27822.1 - 6.8e-25 88.2 0.0 1.1e-24 87.5 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOO27822.1 - 6.5e-15 55.3 0.0 1.3e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.20 KOO27822.1 - 2.5e-11 43.4 0.0 7.4e-11 42.0 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin ShK PF01549.24 KOO27822.1 - 1.4e-06 28.7 11.8 0.0012 19.3 3.3 2.4 2 0 0 2 2 2 2 ShK domain-like ASC PF00858.24 KOO27822.1 - 0.15 11.0 0.4 0.28 10.1 0.4 1.4 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel SBBP PF06739.11 KOO27823.1 - 0.34 10.9 15.2 6.2 6.9 3.7 3.5 3 0 0 3 3 3 0 Beta-propeller repeat Kelch_4 PF13418.6 KOO27824.1 - 6.6e-22 77.3 9.9 6.2e-08 32.5 0.0 7.5 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KOO27824.1 - 6.6e-19 67.7 15.6 0.00025 21.2 0.8 9.2 9 0 0 9 9 9 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO27824.1 - 4.2e-13 49.0 0.0 0.0013 18.7 0.0 6.3 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 KOO27824.1 - 1.1e-11 44.5 0.0 0.95 9.8 0.0 6.7 6 1 1 7 7 7 4 Kelch motif Kelch_1 PF01344.25 KOO27824.1 - 2.2e-10 39.9 0.4 1.6 8.4 0.1 6.9 7 0 0 7 7 7 3 Kelch motif TIG PF01833.24 KOO27824.1 - 1.4e-08 34.7 0.0 0.0029 17.6 0.0 3.5 3 1 0 3 3 3 2 IPT/TIG domain Kelch_2 PF07646.15 KOO27824.1 - 1.4e-07 31.2 0.0 2.6 8.2 0.0 5.9 5 0 0 5 5 5 2 Kelch motif PX PF00787.24 KOO27825.1 - 0.00021 21.2 0.0 0.00038 20.4 0.0 1.3 1 0 0 1 1 1 1 PX domain HC2 PF07382.11 KOO27826.1 - 3.1e-12 47.0 74.5 7.1e-12 45.8 74.5 1.5 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Glyco_transf_8 PF01501.20 KOO27826.1 - 3.3e-08 33.4 0.0 1.6e-07 31.1 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 8 ShK PF01549.24 KOO27826.1 - 0.00014 22.3 4.9 0.00014 22.3 4.9 3.0 3 0 0 3 3 3 1 ShK domain-like Asp-B-Hydro_N PF05279.11 KOO27826.1 - 5.8 6.9 21.1 14 5.6 21.1 1.6 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TPR_12 PF13424.6 KOO27827.1 - 1.6e-19 69.9 3.8 7.2e-10 39.0 0.1 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO27827.1 - 1.5e-14 53.3 2.7 0.0011 18.8 0.0 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27827.1 - 8.3e-14 50.5 16.1 0.0012 18.8 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27827.1 - 5.4e-11 41.8 2.5 0.00022 21.2 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO27827.1 - 1.1e-10 40.8 14.6 1.6e-05 24.5 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO27827.1 - 1.3e-09 37.9 0.2 0.00075 19.0 0.1 2.4 1 1 1 2 2 2 2 MalT-like TPR region TPR_7 PF13176.6 KOO27827.1 - 1.7e-09 37.1 8.1 0.00029 20.6 0.0 5.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27827.1 - 1.3e-07 32.2 0.7 0.0017 18.9 0.0 4.1 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO27827.1 - 3.1e-07 30.6 6.9 4.4 8.4 0.0 6.6 7 0 0 7 7 6 1 Tetratricopeptide repeat SNAP PF14938.6 KOO27827.1 - 7.5e-05 22.3 4.5 0.6 9.5 0.0 3.7 1 1 3 4 4 4 2 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 KOO27827.1 - 0.00099 19.6 4.8 3.8 8.3 0.0 5.3 6 1 0 6 6 4 1 Tetratricopeptide repeat EcoEI_R_C PF08463.10 KOO27827.1 - 0.01 16.0 0.9 0.44 10.6 0.1 3.0 2 1 0 2 2 2 0 EcoEI R protein C-terminal TPR_19 PF14559.6 KOO27827.1 - 0.022 15.2 3.7 2.4 8.7 0.1 3.9 2 1 3 5 5 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO27827.1 - 0.052 13.7 0.4 2.3 8.5 0.0 3.5 2 2 1 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.9 KOO27827.1 - 0.067 12.9 5.1 9.6 5.9 0.0 4.3 3 2 2 5 5 5 0 26S proteasome subunit RPN7 Hs1pro-1_C PF07014.12 KOO27827.1 - 0.12 11.8 0.1 1.6 8.1 0.2 2.2 2 0 0 2 2 2 0 Hs1pro-1 protein C-terminus TPR_11 PF13414.6 KOO27827.1 - 0.14 11.8 0.5 1.2e+02 2.4 0.0 4.3 4 0 0 4 4 4 0 TPR repeat PPR PF01535.20 KOO27827.1 - 0.18 12.1 1.6 74 3.9 0.0 4.7 4 0 0 4 4 4 0 PPR repeat HEAT_PBS PF03130.16 KOO27827.1 - 0.23 12.3 2.3 20 6.2 0.0 4.3 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat SufE PF02657.15 KOO27828.1 - 1.1e-33 115.7 0.0 1.5e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Fe-S metabolism associated domain BolA PF01722.18 KOO27828.1 - 3.8e-09 36.7 0.4 8e-09 35.7 0.4 1.5 1 0 0 1 1 1 1 BolA-like protein S8_pro-domain PF16470.5 KOO27829.1 - 0.0016 19.1 0.3 1.8e+02 3.0 0.0 5.3 5 0 0 5 5 5 0 Peptidase S8 pro-domain SBBP PF06739.11 KOO27829.1 - 0.0032 17.4 78.5 0.18 11.8 0.5 13.0 13 0 0 13 13 13 7 Beta-propeller repeat 120_Rick_ant PF12574.8 KOO27829.1 - 0.013 14.7 3.4 30 3.7 0.0 4.5 4 0 0 4 4 4 0 120 KDa Rickettsia surface antigen DUF3474 PF11960.8 KOO27829.1 - 0.091 13.0 0.0 66 3.7 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF3474) Lactamase_B PF00753.27 KOO27829.1 - 2 8.4 30.6 0.62 10.0 1.0 6.2 3 1 2 6 6 6 0 Metallo-beta-lactamase superfamily FA_hydroxylase PF04116.13 KOO27831.1 - 1.7e-23 83.4 8.1 1.2e-22 80.7 7.9 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Sulfotransfer_2 PF03567.14 KOO27832.1 - 2.7e-08 34.0 0.2 5.5e-06 26.5 0.0 2.3 2 0 0 2 2 2 2 Sulfotransferase family DUF1127 PF06568.11 KOO27832.1 - 3.1 7.6 13.0 0.058 13.1 0.4 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1127) EF-hand_1 PF00036.32 KOO27834.1 - 1.2e-10 40.1 0.3 2e-05 23.8 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO27834.1 - 1.9e-10 41.1 1.8 3.2e-10 40.3 0.1 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO27834.1 - 2.1e-10 39.7 0.2 1.5e-06 27.7 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO27834.1 - 1.7e-06 27.8 0.3 1e-05 25.3 0.0 2.3 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO27834.1 - 0.00066 19.1 0.0 0.00066 19.1 0.0 2.4 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 KOO27834.1 - 0.038 14.3 0.1 0.17 12.2 0.1 1.9 2 0 0 2 2 2 0 EF-hand domain EF-hand_14 PF17959.1 KOO27834.1 - 0.1 13.0 0.2 2 8.8 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain PqqD PF05402.12 KOO27834.1 - 0.49 10.7 2.8 8.1 6.8 0.5 3.1 3 1 0 3 3 3 0 Coenzyme PQQ synthesis protein D (PqqD) CobN-Mg_chel PF02514.16 KOO27836.1 - 0 1112.9 0.0 0 1112.6 0.0 1.1 1 0 0 1 1 1 1 CobN/Magnesium Chelatase DUF3479 PF11965.8 KOO27836.1 - 1e-48 165.5 1.2 1.4e-48 165.0 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3479) PAP_fibrillin PF04755.12 KOO27839.1 - 2.3e-11 44.0 0.0 5.3e-11 42.8 0.0 1.6 1 1 0 1 1 1 1 PAP_fibrillin UPF0054 PF02130.17 KOO27840.1 - 6.9e-36 122.9 0.0 9.1e-36 122.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 Galactosyl_T PF01762.21 KOO27841.1 - 0.16 11.7 0.0 0.27 11.1 0.0 1.2 1 0 0 1 1 1 0 Galactosyltransferase Chromo PF00385.24 KOO27843.1 - 1.2e-05 25.1 0.0 2.1e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ADIP PF11559.8 KOO27843.1 - 1.1 9.3 4.8 3.3 7.8 4.6 1.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Mito_carr PF00153.27 KOO27845.1 - 3.3e-20 71.8 6.9 2.1e-09 37.2 0.1 4.3 3 1 1 4 4 4 4 Mitochondrial carrier protein LapA_dom PF06305.11 KOO27845.1 - 0.2 11.5 0.9 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Dynamin_N PF00350.23 KOO27846.1 - 9.2e-14 51.8 0.0 3.1e-13 50.1 0.0 1.9 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KOO27846.1 - 7.5e-06 26.0 0.0 0.00016 21.7 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KOO27846.1 - 0.0016 19.0 0.0 0.0063 17.0 0.0 2.1 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 KOO27846.1 - 0.0026 17.7 0.5 0.0062 16.5 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase COX14 PF14880.6 KOO27846.1 - 0.04 13.7 0.1 0.43 10.5 0.0 2.5 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF87 PF01935.17 KOO27846.1 - 0.13 12.4 0.5 0.48 10.5 0.5 2.0 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_23 PF13476.6 KOO27846.1 - 6.8 7.1 5.7 4 7.9 0.2 2.4 2 0 0 2 2 2 0 AAA domain PP2C PF00481.21 KOO27847.1 - 8.8e-45 153.3 0.0 1.8e-44 152.3 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C Pkinase PF00069.25 KOO27847.1 - 1.5e-36 126.2 0.0 2.2e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27847.1 - 8.4e-27 94.1 0.0 2.1e-24 86.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO27847.1 - 1.5e-07 30.6 0.0 2.4e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase PP2C_2 PF13672.6 KOO27847.1 - 1.9e-05 24.4 0.4 5.6e-05 22.9 0.4 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SAP PF02037.27 KOO27847.1 - 0.00087 19.0 1.8 0.0027 17.4 0.0 2.6 3 0 0 3 3 3 1 SAP domain Kdo PF06293.14 KOO27847.1 - 0.0018 17.6 0.1 0.0039 16.6 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO27847.1 - 0.0079 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO27847.1 - 0.31 10.9 3.4 0.56 10.1 0.2 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family Sulfotransfer_3 PF13469.6 KOO27848.1 - 0.0075 16.7 1.2 0.77 10.1 0.1 2.3 1 1 0 2 2 2 2 Sulfotransferase family zf-tcix PF14952.6 KOO27849.1 - 0.0015 18.1 1.2 0.0029 17.2 1.2 1.4 1 0 0 1 1 1 1 Putative treble-clef, zinc-finger, Zn-binding UPF0547 PF10571.9 KOO27849.1 - 0.13 12.3 2.2 0.28 11.3 2.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 BDV_P24 PF06595.11 KOO27849.1 - 0.16 11.8 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Borna disease virus P24 protein zf-RanBP PF00641.18 KOO27849.1 - 0.23 10.8 1.2 0.42 10.0 1.2 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others NAD_binding_10 PF13460.6 KOO27850.1 - 2.3e-16 60.2 0.6 2.7e-16 60.0 0.6 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO27850.1 - 5e-10 39.3 0.3 6.6e-10 38.9 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 KOO27850.1 - 8.2e-05 22.2 0.0 0.00011 21.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO27850.1 - 0.00025 20.1 0.0 0.00029 19.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 KOO27850.1 - 0.016 15.3 0.3 0.025 14.7 0.3 1.5 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 KOO27850.1 - 0.033 14.6 0.1 0.052 14.0 0.1 1.4 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain adh_short PF00106.25 KOO27850.1 - 0.048 13.1 0.2 0.072 12.5 0.2 1.3 1 0 0 1 1 1 0 short chain dehydrogenase PSK_trans_fac PF07704.11 KOO27851.1 - 0.069 13.9 3.3 0.085 13.6 3.3 1.2 1 0 0 1 1 1 0 Rv0623-like transcription factor Ribosomal_L37 PF08561.10 KOO27851.1 - 2.6 8.6 7.8 14 6.2 7.8 2.0 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L37 DUF3562 PF12085.8 KOO27852.1 - 0.098 12.3 0.1 1.4 8.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3562) Pkinase_Tyr PF07714.17 KOO27853.1 - 6.6e-20 71.5 0.0 1.9e-16 60.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KOO27853.1 - 3.5e-15 56.1 0.0 1.7e-13 50.6 0.0 2.1 1 1 0 2 2 2 1 Protein kinase domain LRR_8 PF13855.6 KOO27853.1 - 1.1e-14 53.9 7.6 6.8e-06 25.8 0.7 4.3 2 2 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 KOO27853.1 - 1.6e-06 28.3 14.3 0.034 14.6 1.2 5.4 2 1 6 8 8 8 5 Leucine Rich repeats (2 copies) Kdo PF06293.14 KOO27853.1 - 0.00035 20.0 0.0 0.00054 19.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO27853.1 - 0.0091 15.9 0.0 0.21 11.5 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family LRR_9 PF14580.6 KOO27853.1 - 0.013 15.0 0.9 1.6 8.2 0.0 2.3 1 1 1 2 2 2 0 Leucine-rich repeat Phage_integrase PF00589.22 KOO27855.1 - 0.00039 20.2 0.3 0.0013 18.6 0.0 2.2 2 1 0 2 2 2 1 Phage integrase family ABC_membrane PF00664.23 KOO27855.1 - 0.23 11.1 0.0 0.36 10.5 0.0 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region DUF1168 PF06658.12 KOO27857.1 - 6.2e-28 97.3 21.1 7.9e-28 97.0 21.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) DUF4722 PF15849.5 KOO27857.1 - 0.31 10.8 3.6 0.36 10.5 2.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4722) RR_TM4-6 PF06459.12 KOO27857.1 - 0.45 10.3 15.5 0.55 10.0 15.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GNAT_acetyltr_2 PF13718.6 KOO27857.1 - 0.47 9.8 4.6 0.82 9.0 4.6 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 FmdE PF02663.14 KOO27857.1 - 1.2 9.2 5.5 1.4 9.0 4.7 1.5 1 1 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon RNA_polI_A34 PF08208.11 KOO27857.1 - 1.9 8.5 16.0 3 7.9 16.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Connexin PF00029.19 KOO27857.1 - 2.5 7.8 5.4 2.6 7.7 5.4 1.3 1 0 0 1 1 1 0 Connexin Paf1 PF03985.13 KOO27857.1 - 3.6 6.5 15.2 6 5.8 15.2 1.3 1 0 0 1 1 1 0 Paf1 Neur_chan_memb PF02932.16 KOO27857.1 - 4 7.4 5.2 4.7 7.2 5.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 KOO27857.1 - 7.3 5.9 15.7 8.3 5.7 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XRN_M PF17846.1 KOO27857.1 - 8.1 5.3 8.1 8.4 5.2 8.1 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Peptidase_S49_N PF08496.10 KOO27857.1 - 8.1 6.5 13.1 8.9 6.4 11.1 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal GGACT PF06094.12 KOO27859.1 - 4.5e-07 30.5 0.1 7e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like YscO-like PF16789.5 KOO27859.1 - 0.046 13.8 1.4 0.073 13.1 1.4 1.3 1 0 0 1 1 1 0 YscO-like protein HEAT_2 PF13646.6 KOO27860.1 - 0.00029 21.2 19.5 0.41 11.1 0.1 6.0 4 2 1 5 5 5 3 HEAT repeats HEAT PF02985.22 KOO27860.1 - 0.0074 16.5 3.3 0.6 10.5 0.1 3.6 3 0 0 3 3 3 2 HEAT repeat HEAT_PBS PF03130.16 KOO27860.1 - 0.077 13.7 25.4 0.3 11.9 0.9 6.4 8 0 0 8 8 8 0 PBS lyase HEAT-like repeat RTP1_C2 PF10304.9 KOO27860.1 - 1.9 8.3 4.4 1.8 8.4 0.2 2.8 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 2 Polyketide_cyc2 PF10604.9 KOO27861.1 - 1.6e-05 25.2 0.0 1.9e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport FAM163 PF15069.6 KOO27861.1 - 0.062 13.8 0.0 0.086 13.3 0.0 1.3 1 0 0 1 1 1 0 FAM163 family Sulfotransfer_1 PF00685.27 KOO27862.1 - 2.5e-35 122.3 0.0 1.4e-34 119.8 0.0 1.9 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KOO27862.1 - 4.8e-06 27.1 0.1 0.0031 17.9 0.0 2.3 1 1 1 2 2 2 2 Sulfotransferase family Cas_Csa4 PF09703.10 KOO27862.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa4) tRNA-synt_1 PF00133.22 KOO27863.1 - 2.1e-116 389.6 0.0 2.5e-116 389.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KOO27863.1 - 1.2e-14 53.9 0.0 2.8e-07 29.7 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KOO27863.1 - 4.1e-09 36.6 0.0 7.7e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 KOO27863.1 - 3.1e-08 33.4 0.0 5.8e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 KOO27863.1 - 8.6e-08 32.4 0.4 8.6e-08 32.4 0.4 1.8 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1f PF01921.18 KOO27863.1 - 0.0045 15.9 0.0 0.0069 15.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (K) tRNA-synt_1e PF01406.19 KOO27863.1 - 0.036 13.4 0.0 0.056 12.8 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.22 KOO27864.1 - 1.7e-55 188.4 0.0 2.1e-55 188.1 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KOO27864.1 - 4.6e-08 32.2 0.0 1.1e-07 31.0 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (M) Exostosin PF03016.15 KOO27866.1 - 1e-31 110.3 0.3 2.6e-31 108.9 0.3 1.7 1 1 0 1 1 1 1 Exostosin family BNR_2 PF13088.6 KOO27867.1 - 4.9e-37 127.7 0.0 6.9e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.6 KOO27867.1 - 2.7e-12 46.6 0.0 4.1e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 KOO27867.1 - 3.6e-08 32.2 15.4 0.11 12.5 0.3 5.5 5 0 0 5 5 5 4 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KOO27867.1 - 0.25 10.1 2.0 1.8 7.2 0.1 2.9 4 1 1 5 5 5 0 Sortilin, neurotensin receptor 3, Zn-ribbon_8 PF09723.10 KOO27868.1 - 0.0016 18.5 0.1 0.0039 17.3 0.1 1.7 1 0 0 1 1 1 1 Zinc ribbon domain DZR PF12773.7 KOO27868.1 - 0.0096 15.9 0.6 0.017 15.1 0.6 1.4 1 0 0 1 1 1 1 Double zinc ribbon Cytidylate_kin PF02224.18 KOO27868.1 - 0.011 15.5 0.1 0.035 13.8 0.0 1.9 2 1 0 2 2 2 0 Cytidylate kinase AAA_16 PF13191.6 KOO27868.1 - 0.017 15.5 0.0 0.029 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain zinc_ribbon_4 PF13717.6 KOO27868.1 - 0.019 14.9 1.1 0.095 12.6 1.1 2.3 1 1 0 1 1 1 0 zinc-ribbon domain SRP54 PF00448.22 KOO27868.1 - 0.026 14.1 0.2 0.05 13.2 0.2 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_POL_M_15KD PF02150.16 KOO27868.1 - 0.042 13.7 0.2 0.079 12.8 0.2 1.4 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit AAA_30 PF13604.6 KOO27868.1 - 0.049 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain zf-ribbon_3 PF13248.6 KOO27868.1 - 0.07 12.6 1.3 2.9 7.4 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.6 KOO27868.1 - 0.11 12.3 0.4 0.21 11.3 0.4 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zf-TFIIB PF13453.6 KOO27868.1 - 0.14 11.5 0.4 0.29 10.5 0.4 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger CAP_N PF01213.19 KOO27868.1 - 0.44 10.0 5.3 0.25 10.8 1.1 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 KOO27868.1 - 6.3 6.9 6.6 2.1 8.4 0.9 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Ank_2 PF12796.7 KOO27870.1 - 1.9e-27 95.7 2.1 4.1e-10 40.1 0.0 2.7 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO27870.1 - 1e-19 70.3 5.2 2.6e-06 27.6 0.0 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO27870.1 - 5.8e-17 61.3 4.2 0.00036 20.8 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 KOO27870.1 - 1.4e-15 55.8 3.9 0.0064 16.9 0.1 5.3 6 1 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 KOO27870.1 - 1.5e-14 54.2 1.3 2.7e-07 31.0 0.2 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) TPR_1 PF00515.28 KOO27871.1 - 9.8e-35 117.0 45.7 8.8e-05 22.2 0.3 15.5 16 0 0 16 16 15 9 Tetratricopeptide repeat TPR_2 PF07719.17 KOO27871.1 - 1.7e-34 115.1 68.3 0.0032 17.5 0.3 18.0 20 0 0 20 20 18 11 Tetratricopeptide repeat TPR_19 PF14559.6 KOO27871.1 - 4.1e-28 97.7 65.9 5e-07 30.1 0.6 13.1 10 4 2 13 13 12 7 Tetratricopeptide repeat TPR_17 PF13431.6 KOO27871.1 - 5.7e-27 92.1 32.5 0.012 15.9 0.0 14.7 15 0 0 15 15 15 8 Tetratricopeptide repeat TPR_12 PF13424.6 KOO27871.1 - 7e-26 90.3 66.7 1.6e-06 28.3 0.8 13.6 9 3 6 15 15 15 9 Tetratricopeptide repeat TPR_8 PF13181.6 KOO27871.1 - 7.1e-26 88.2 40.5 0.074 13.3 0.0 17.1 18 0 0 18 18 18 8 Tetratricopeptide repeat TPR_16 PF13432.6 KOO27871.1 - 6.2e-23 81.2 101.3 2.1e-06 28.2 0.1 15.2 8 5 11 19 19 17 10 Tetratricopeptide repeat TPR_14 PF13428.6 KOO27871.1 - 3.9e-19 67.7 72.5 0.00019 22.0 0.4 18.5 8 5 11 19 19 17 8 Tetratricopeptide repeat TPR_11 PF13414.6 KOO27871.1 - 1.7e-16 59.6 32.1 0.0042 16.8 0.0 12.2 8 3 5 13 13 13 5 TPR repeat TPR_7 PF13176.6 KOO27871.1 - 3.9e-15 54.7 43.7 0.44 10.7 0.2 15.5 16 0 0 16 16 15 5 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO27871.1 - 3.4e-13 49.6 29.8 0.0012 19.0 7.9 7.7 5 3 4 9 9 9 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KOO27871.1 - 1.1e-08 35.2 44.4 0.62 10.8 0.1 15.3 16 0 0 16 16 15 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO27871.1 - 3.7e-07 30.2 13.5 0.009 16.1 0.2 7.6 6 1 2 8 8 8 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO27871.1 - 1.1e-05 25.2 44.0 2 8.4 0.0 13.9 15 1 1 16 16 16 4 Tetratricopeptide repeat Vps39_1 PF10366.9 KOO27871.1 - 0.015 15.5 0.2 5.3 7.4 0.1 3.0 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 NARP1 PF12569.8 KOO27871.1 - 0.029 13.3 37.5 0.3 10.0 0.2 5.3 4 1 0 5 5 5 0 NMDA receptor-regulated protein 1 ChAPs PF09295.10 KOO27871.1 - 0.061 12.3 1.2 0.72 8.8 0.2 2.4 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF4919 PF16266.5 KOO27871.1 - 0.071 13.1 0.2 19 5.1 0.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4919) Glycos_transf_1 PF00534.20 KOO27873.1 - 1.3e-23 83.4 0.0 2.9e-23 82.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOO27873.1 - 1.1e-17 64.7 0.0 3.4e-17 63.1 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOO27873.1 - 6.7e-10 39.2 0.2 2.1e-09 37.6 0.2 1.8 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 KOO27873.1 - 5.9e-05 23.6 0.2 0.0004 20.9 0.0 2.5 2 1 1 3 3 3 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 KOO27873.1 - 0.00082 19.4 0.1 0.0014 18.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like DUF2892 PF11127.8 KOO27873.1 - 0.63 10.1 5.0 2.4 8.3 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) DENN PF02141.21 KOO27875.1 - 1.5e-26 93.5 0.6 1.9e-26 93.1 0.6 1.1 1 0 0 1 1 1 1 DENN (AEX-3) domain CPSase_L_D2 PF02786.17 KOO27876.1 - 4.3e-76 255.1 0.4 6.7e-76 254.5 0.4 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KOO27876.1 - 6.3e-41 139.4 0.8 1.2e-40 138.5 0.1 1.8 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOO27876.1 - 3.2e-31 107.6 0.0 7.1e-31 106.5 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KOO27876.1 - 6.8e-16 57.9 0.2 1.7e-15 56.6 0.0 1.8 2 0 0 2 2 2 1 Biotin-requiring enzyme ATP-grasp PF02222.22 KOO27876.1 - 7.4e-07 28.9 0.1 1.3e-06 28.1 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KOO27876.1 - 1.2e-06 28.2 0.1 5.1e-06 26.2 0.1 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus PCC_BT PF18140.1 KOO27876.1 - 0.00012 22.4 3.3 0.0018 18.6 0.0 2.9 3 0 0 3 3 3 1 Propionyl-coenzyme A carboxylase BT domain ATP-grasp_5 PF13549.6 KOO27876.1 - 0.0005 19.6 0.2 0.0011 18.4 0.2 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 KOO27876.1 - 0.0011 18.8 0.2 0.02 14.7 0.1 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like ATP-grasp_3 PF02655.14 KOO27876.1 - 0.02 15.0 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain HlyD_3 PF13437.6 KOO27876.1 - 0.057 14.1 0.2 13 6.5 0.1 3.0 3 0 0 3 3 2 0 HlyD family secretion protein LRR_4 PF12799.7 KOO27878.1 - 2.4e-10 40.5 13.5 5.7e-05 23.4 1.8 4.2 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO27878.1 - 1.1e-07 31.5 7.9 0.0011 18.6 2.2 3.7 3 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 KOO27878.1 - 0.0019 18.1 10.0 13 6.2 0.2 5.0 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 KOO27878.1 - 0.25 12.0 8.5 83 4.4 0.4 5.2 5 1 0 5 5 5 0 Leucine Rich Repeat MSA-2c PF12238.8 KOO27878.1 - 9.5 6.2 6.3 2.9 7.9 3.2 1.8 2 0 0 2 2 2 0 Merozoite surface antigen 2c PUA_3 PF17785.1 KOO27879.1 - 0.024 14.4 0.0 0.07 12.9 0.0 1.8 1 1 0 1 1 1 0 PUA-like domain RNase_H2_suC PF08615.11 KOO27880.1 - 2.5e-18 66.6 0.2 9.6e-16 58.2 0.2 2.8 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) AAA_28 PF13521.6 KOO27880.1 - 0.024 14.9 0.0 0.028 14.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain LamB_YcsF PF03746.16 KOO27880.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 LamB/YcsF family Pkinase PF00069.25 KOO27881.1 - 1.7e-64 217.8 0.0 2e-64 217.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27881.1 - 5.2e-33 114.4 0.0 7.3e-33 113.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO27881.1 - 3e-08 33.3 0.0 5e-08 32.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KOO27881.1 - 6.1e-06 26.3 1.3 4.6e-05 23.5 1.4 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KOO27881.1 - 1.6e-05 24.4 0.7 2.5e-05 23.7 0.7 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOO27881.1 - 0.0017 18.0 0.3 0.0027 17.3 0.3 1.2 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 KOO27881.1 - 0.013 14.5 0.2 0.017 14.1 0.2 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Choline_kinase PF01633.20 KOO27881.1 - 0.062 12.9 0.4 0.21 11.1 0.4 1.8 1 1 0 1 1 1 0 Choline/ethanolamine kinase Vault_3 PF17795.1 KOO27881.1 - 0.24 11.5 1.8 1.3 9.1 0.1 2.7 3 0 0 3 3 3 0 Major Vault Protein Repeat domain Methyltransf_4 PF02390.17 KOO27882.1 - 3.9e-44 150.2 0.0 4.3e-43 146.8 0.0 2.0 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.6 KOO27882.1 - 5.8e-07 29.4 0.0 9e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO27882.1 - 2.6e-06 28.0 0.0 0.0012 19.5 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 KOO27882.1 - 7.7e-05 22.3 0.0 0.0035 16.9 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.12 KOO27882.1 - 0.00031 21.3 0.0 0.015 16.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOO27882.1 - 0.00032 20.7 0.0 0.00042 20.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO27882.1 - 0.0034 18.1 0.0 0.012 16.3 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO27882.1 - 0.0099 15.7 0.0 0.026 14.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 KOO27882.1 - 0.1 12.1 0.0 0.23 10.9 0.0 1.5 1 1 0 1 1 1 0 Histone methylation protein DOT1 DUF3138 PF11336.8 KOO27882.1 - 0.34 9.5 2.8 0.46 9.0 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) ABC_membrane PF00664.23 KOO27883.1 - 9.4e-36 123.9 3.3 1.4e-35 123.3 3.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOO27883.1 - 3.1e-22 79.6 0.0 2.1e-12 47.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_33 PF13671.6 KOO27883.1 - 0.026 14.7 0.1 0.075 13.2 0.2 1.7 2 0 0 2 2 2 0 AAA domain Lys_export PF03956.13 KOO27883.1 - 0.03 13.9 2.4 0.069 12.7 2.4 1.6 1 0 0 1 1 1 0 Lysine exporter LysO AAA_29 PF13555.6 KOO27883.1 - 0.067 12.9 0.2 0.24 11.1 0.2 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF418 PF04235.12 KOO27883.1 - 0.42 10.5 4.2 1.1 9.2 4.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF418) AAA_25 PF13481.6 KOO27883.1 - 0.72 9.4 3.5 0.32 10.5 0.2 2.0 2 0 0 2 2 2 0 AAA domain Synaptobrevin PF00957.21 KOO27885.1 - 9.5e-22 76.6 0.8 1.1e-21 76.4 0.8 1.0 1 0 0 1 1 1 1 Synaptobrevin m04gp34like PF12216.8 KOO27885.1 - 0.0093 15.6 0.0 0.012 15.2 0.0 1.0 1 0 0 1 1 1 1 Immune evasion protein DUF2972 PF11186.8 KOO27885.1 - 0.037 14.0 0.0 0.043 13.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2972) Peptidase_C2 PF00648.21 KOO27886.1 - 8.2e-57 192.5 0.1 1.2e-56 191.9 0.1 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KOO27886.1 - 1e-24 87.4 0.0 4.4e-11 43.2 0.0 3.4 3 0 0 3 3 3 3 Calpain large subunit, domain III WWE PF02825.20 KOO27887.1 - 4.1e-12 46.5 3.5 0.00013 22.5 1.5 3.3 3 0 0 3 3 3 2 WWE domain zf-RING_2 PF13639.6 KOO27887.1 - 3.5e-10 40.1 5.4 6e-10 39.3 5.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOO27887.1 - 5.5e-07 29.4 4.3 8.8e-07 28.7 4.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOO27887.1 - 2.2e-06 27.3 1.0 4.4e-06 26.3 1.0 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 KOO27887.1 - 9.2e-06 25.9 5.7 2.6e-05 24.4 5.7 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOO27887.1 - 4.3e-05 23.5 2.2 0.00017 21.5 2.2 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 KOO27887.1 - 0.0001 22.1 5.1 0.00021 21.1 5.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO27887.1 - 0.00016 21.6 2.6 0.00031 20.7 2.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOO27887.1 - 0.00017 21.4 2.6 0.00028 20.7 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO27887.1 - 0.00023 21.0 4.1 0.00037 20.4 4.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 KOO27887.1 - 0.0027 17.5 2.9 0.0058 16.4 2.9 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 KOO27887.1 - 0.0084 16.0 1.3 0.019 14.8 1.3 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-HC5HC2H PF13771.6 KOO27887.1 - 0.013 15.7 1.2 0.05 13.8 0.3 2.1 1 1 1 2 2 2 0 PHD-like zinc-binding domain zf-RING-like PF08746.11 KOO27887.1 - 0.023 15.0 3.6 0.058 13.7 3.6 1.8 1 1 0 1 1 1 0 RING-like domain zf-HC5HC2H_2 PF13832.6 KOO27887.1 - 0.064 13.4 0.9 0.23 11.6 0.2 2.0 1 1 1 2 2 2 0 PHD-zinc-finger like domain zf-Nse PF11789.8 KOO27887.1 - 0.084 12.7 1.5 0.15 11.9 1.5 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PHD PF00628.29 KOO27887.1 - 0.094 12.6 2.3 0.2 11.6 2.3 1.6 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 KOO27887.1 - 0.1 12.7 1.4 0.18 11.9 1.4 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger FANCL_C PF11793.8 KOO27887.1 - 0.22 11.7 3.4 0.7 10.1 3.4 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain COPIIcoated_ERV PF07970.12 KOO27888.1 - 1.7e-49 168.7 0.8 2.7e-42 145.1 0.2 2.1 1 1 1 2 2 2 2 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOO27888.1 - 3.5e-28 97.8 0.0 7e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Chromate_transp PF02417.15 KOO27888.1 - 0.093 12.9 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Chromate transporter Barwin PF00967.17 KOO27888.1 - 0.098 12.5 0.2 0.19 11.6 0.2 1.4 1 0 0 1 1 1 0 Barwin family DUF1275 PF06912.11 KOO27890.1 - 1.9e-15 57.3 0.5 3e-15 56.7 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Mito_carr PF00153.27 KOO27891.1 - 1.5e-50 169.1 1.1 5.6e-17 61.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Cupin_8 PF13621.6 KOO27892.1 - 1.1e-24 87.6 0.0 1.4e-24 87.2 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO27892.1 - 0.0009 18.8 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 KOO27892.1 - 0.0015 18.2 0.0 0.055 13.2 0.0 2.3 2 0 0 2 2 2 1 Cupin domain Cupin_6 PF12852.7 KOO27892.1 - 0.002 17.9 0.0 0.0037 17.0 0.0 1.5 1 0 0 1 1 1 1 Cupin JmjC PF02373.22 KOO27892.1 - 0.0075 16.7 0.0 0.01 16.2 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_1 PF00190.22 KOO27892.1 - 0.073 12.7 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 Cupin ASF1_hist_chap PF04729.13 KOO27893.1 - 3e-66 222.1 0.1 3.4e-66 222.0 0.1 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone EF-hand_1 PF00036.32 KOO27894.1 - 2.1e-14 51.9 0.5 9.5e-06 24.8 0.1 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO27894.1 - 6.4e-14 52.2 0.1 2.1e-13 50.5 0.0 1.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO27894.1 - 2.4e-13 48.9 0.2 1.7e-06 27.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO27894.1 - 2.6e-11 43.2 0.1 2.3e-08 33.7 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO27894.1 - 2.5e-10 39.4 0.2 7.8e-05 22.3 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 KOO27894.1 - 0.00018 21.4 0.0 0.0011 18.8 0.0 2.0 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO27894.1 - 0.001 19.4 0.0 0.0017 18.6 0.0 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO27894.1 - 0.0055 17.6 0.1 0.014 16.2 0.0 1.7 2 0 0 2 2 2 1 EF-hand domain DUF2756 PF10956.8 KOO27894.1 - 0.094 13.2 0.6 0.094 13.2 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2756) Flg_hook PF02120.16 KOO27894.1 - 0.47 10.4 4.4 13 5.8 0.4 2.7 2 1 1 3 3 3 0 Flagellar hook-length control protein FliK Choline_kinase PF01633.20 KOO27895.1 - 9.3e-21 74.4 0.0 1.3e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 KOO27895.1 - 5.5e-11 42.9 0.1 5.5e-11 42.9 0.1 2.4 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KOO27895.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ASF1_hist_chap PF04729.13 KOO27896.1 - 3e-66 222.1 0.1 3.4e-66 222.0 0.1 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Cu-oxidase_2 PF07731.14 KOO27899.1 - 0.01 15.6 0.3 0.015 15.0 0.3 1.3 1 0 0 1 1 1 1 Multicopper oxidase DUF1717 PF05414.11 KOO27899.1 - 0.023 15.1 0.0 0.043 14.3 0.0 1.4 1 0 0 1 1 1 0 Viral domain of unknown function (DUF1717) AA_kinase PF00696.28 KOO27900.1 - 2e-39 135.6 0.3 1.9e-38 132.4 0.0 2.5 3 0 0 3 3 3 1 Amino acid kinase family Homoserine_dh PF00742.19 KOO27900.1 - 1.2e-37 129.5 0.0 3.7e-37 127.9 0.0 1.9 2 0 0 2 2 2 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 KOO27900.1 - 8.2e-16 58.7 0.3 1e-14 55.2 0.0 2.9 3 0 0 3 3 3 1 Homoserine dehydrogenase, NAD binding domain ACT PF01842.25 KOO27900.1 - 9.1e-10 38.1 0.2 4.8e-06 26.2 0.0 2.7 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 KOO27900.1 - 1.9e-09 37.2 0.2 5.8e-06 26.0 0.0 2.8 2 0 0 2 2 2 2 ACT domain Semialdhyde_dh PF01118.24 KOO27900.1 - 0.00083 19.8 0.6 0.011 16.2 0.2 2.9 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain RNase_II_C_S1 PF18614.1 KOO27900.1 - 0.0084 16.0 0.4 0.029 14.3 0.4 2.0 1 0 0 1 1 1 1 RNase II-type exonuclease C-terminal S1 domain DnaJ PF00226.31 KOO27901.1 - 1.2e-12 47.8 5.4 9.7e-08 32.0 0.2 3.2 3 0 0 3 3 3 2 DnaJ domain Pox_MCEL PF03291.16 KOO27902.1 - 5.1e-69 232.9 0.0 9e-69 232.1 0.0 1.3 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 KOO27902.1 - 1.1e-08 35.6 0.1 3.6e-08 34.0 0.1 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO27902.1 - 4.2e-05 23.4 0.1 0.00013 21.8 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO27902.1 - 0.00026 20.8 0.0 0.00053 19.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO27902.1 - 0.0033 18.1 0.0 0.0094 16.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO27902.1 - 0.0064 17.2 0.0 0.023 15.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain APOBEC_N PF08210.11 KOO27903.1 - 0.0096 15.8 4.0 1.2 9.0 0.1 3.2 3 0 0 3 3 3 2 APOBEC-like N-terminal domain DUF309 PF03745.14 KOO27903.1 - 0.028 14.1 17.6 44 3.9 0.0 6.4 6 0 0 6 6 6 0 Domain of unknown function (DUF309) Paired_CXXCH_1 PF09699.10 KOO27903.1 - 0.051 13.3 5.1 0.1 12.4 5.1 1.5 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) PSCyt1 PF07635.11 KOO27903.1 - 2.9 8.5 10.5 72 4.1 0.0 5.6 5 1 1 6 6 6 0 Planctomycete cytochrome C DEAD PF00270.29 KOO27904.1 - 1e-31 110.1 0.0 2.2e-31 109.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO27904.1 - 1e-23 83.8 0.0 2.5e-23 82.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO27904.1 - 0.00011 22.2 0.0 0.00019 21.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit FIST PF08495.10 KOO27904.1 - 0.00013 22.1 0.1 0.00038 20.5 0.0 1.8 2 0 0 2 2 2 1 FIST N domain AAA_22 PF13401.6 KOO27904.1 - 0.014 15.7 0.4 0.1 12.8 0.1 2.6 3 1 0 3 3 3 0 AAA domain ERCC3_RAD25_C PF16203.5 KOO27904.1 - 0.083 12.1 0.0 0.21 10.8 0.0 1.6 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase DnaJ PF00226.31 KOO27905.1 - 1.3e-14 54.0 0.0 3.7e-14 52.6 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain ADH_zinc_N PF00107.26 KOO27905.1 - 1.6e-09 37.8 0.0 3.5e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SAM_1 PF00536.30 KOO27905.1 - 0.0014 19.0 0.6 0.012 16.0 0.6 2.5 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) ADH_N PF08240.12 KOO27905.1 - 0.018 14.9 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Fibin PF15819.5 KOO27905.1 - 0.11 12.2 0.2 0.26 11.0 0.2 1.6 1 0 0 1 1 1 0 Fin bud initiation factor homologue SAM_2 PF07647.17 KOO27905.1 - 0.16 12.1 1.9 0.55 10.4 0.4 2.6 3 1 0 3 3 3 0 SAM domain (Sterile alpha motif) MIB_HERC2 PF06701.13 KOO27907.1 - 1.4e-18 66.8 7.8 1.4e-18 66.8 7.8 1.9 2 0 0 2 2 2 1 Mib_herc2 SH3_15 PF18346.1 KOO27907.1 - 1.1e-12 48.1 9.7 2.4e-09 37.4 0.7 2.7 3 0 0 3 3 3 2 Mind bomb SH3 repeat domain DUF4314 PF14192.6 KOO27907.1 - 0.0039 17.1 5.5 0.0051 16.7 1.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4314) Erv26 PF04148.13 KOO27908.1 - 9.1e-39 133.4 19.8 5.5e-38 130.9 19.8 1.8 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 CTP_transf_1 PF01148.20 KOO27908.1 - 0.86 9.3 17.5 1.1 9.0 17.5 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family BCDHK_Adom3 PF10436.9 KOO27910.1 - 2.5e-18 66.4 0.0 4.5e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase EF-hand_1 PF00036.32 KOO27910.1 - 3.3e-11 41.9 0.1 0.00018 20.8 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO27910.1 - 6.7e-09 35.0 0.3 0.0003 20.5 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO27910.1 - 1e-08 35.5 0.9 2.3e-08 34.4 0.9 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO27910.1 - 1.4e-07 30.6 0.0 0.014 14.9 0.0 2.5 2 0 0 2 2 2 2 EF hand Rdx PF10262.9 KOO27910.1 - 2.8e-05 24.2 0.0 4.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Rdx family EF-hand_8 PF13833.6 KOO27910.1 - 3.3e-05 23.6 0.1 0.037 13.9 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair PP2C PF00481.21 KOO27911.1 - 4.2e-37 128.2 0.1 5.7e-29 101.5 0.2 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C STAR_dimer PF16544.5 KOO27912.1 - 0.0098 15.4 1.2 1.7 8.3 0.1 2.2 2 0 0 2 2 2 2 Homodimerisation region of STAR domain protein ZZ PF00569.17 KOO27912.1 - 0.017 14.9 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type TMF_DNA_bd PF12329.8 KOO27912.1 - 0.4 10.7 5.9 1.2 9.2 1.5 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding PKD_channel PF08016.12 KOO27914.1 - 2.9e-11 42.7 12.4 1.3e-05 24.1 10.8 2.2 1 1 1 2 2 2 2 Polycystin cation channel Tetraspanin PF00335.20 KOO27914.1 - 2 8.1 4.4 16 5.1 1.3 2.8 2 1 0 3 3 3 0 Tetraspanin family Ion_trans PF00520.31 KOO27914.1 - 2.5 7.3 13.8 1.6 7.9 12.0 1.6 2 0 0 2 2 2 0 Ion transport protein Pkinase PF00069.25 KOO27915.1 - 1.8e-62 211.1 0.0 2.1e-62 210.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27915.1 - 1.5e-41 142.4 0.0 2e-41 142.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO27915.1 - 2.3e-05 23.4 0.0 3.3e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO27915.1 - 0.01 15.8 0.1 0.87 9.5 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO27915.1 - 0.011 15.1 0.0 0.041 13.2 0.0 1.8 2 0 0 2 2 2 0 Kinase-like VCBS PF13517.6 KOO27916.1 - 8.8e-137 445.8 157.1 1.5e-14 54.3 4.5 13.3 1 1 13 14 14 14 14 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO27916.1 - 8.6e-65 214.4 131.0 2.1e-05 24.5 1.6 13.5 13 0 0 13 13 13 13 FG-GAP repeat Dockerin_1 PF00404.18 KOO27916.1 - 8.1e-15 54.8 35.7 8.7 6.6 0.0 13.1 13 0 0 13 13 13 5 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO27916.1 - 6.5e-08 32.1 61.4 4.3 6.7 0.2 12.9 3 3 9 13 13 13 11 Insecticide toxin TcdB middle/N-terminal region Arrestin_N PF00339.29 KOO27916.1 - 5.2e-07 29.8 0.0 1.2e+02 2.7 0.0 9.6 10 2 2 13 13 13 0 Arrestin (or S-antigen), N-terminal domain DUF5001 PF16392.5 KOO27916.1 - 5e-05 23.1 0.0 4.4 7.3 0.0 6.0 4 2 4 8 8 8 1 Ig-like domain TM_PBP2_N PF16296.5 KOO27916.1 - 0.0019 18.3 0.0 16 5.7 0.0 7.1 13 0 0 13 13 13 0 N-terminal of TM subunit in PBP-dependent ABC transporters T4BSS_DotH_IcmK PF12293.8 KOO27916.1 - 0.0022 17.3 0.0 43 3.2 0.0 5.3 3 3 4 7 7 7 0 Putative outer membrane core complex of type IVb secretion LpxI_N PF17930.1 KOO27916.1 - 0.094 12.6 0.8 72 3.3 0.0 6.1 12 0 0 12 12 12 0 LpxI N-terminal domain DUF1391 PF07151.12 KOO27916.1 - 0.24 11.2 0.9 6.4 6.7 0.2 3.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1391) EF-hand_1 PF00036.32 KOO27916.1 - 0.94 9.2 62.2 39 4.1 0.2 13.1 13 0 0 13 13 13 0 EF hand EF-hand_5 PF13202.6 KOO27916.1 - 7.6 6.2 90.5 16 5.2 0.8 13.5 13 0 0 13 13 13 0 EF hand FIST PF08495.10 KOO27917.1 - 7.3e-05 22.8 0.6 7.3e-05 22.8 0.6 1.9 1 1 1 2 2 2 1 FIST N domain Ank_2 PF12796.7 KOO27920.1 - 2.8e-38 130.4 12.5 9.5e-12 45.3 0.5 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO27920.1 - 1.3e-25 89.5 1.6 4.7e-09 36.6 0.2 4.2 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO27920.1 - 1.2e-22 77.5 3.2 0.0039 17.6 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 KOO27920.1 - 3.5e-17 62.2 10.5 2.7e-05 24.3 0.3 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KOO27920.1 - 2.5e-16 59.3 12.3 0.0075 16.7 0.0 5.3 5 0 0 5 5 5 5 Ankyrin repeat SNF2_N PF00176.23 KOO27921.1 - 6.3e-43 146.8 0.0 2.5e-33 115.2 0.1 2.4 1 1 1 2 2 2 2 SNF2 family N-terminal domain Agenet PF05641.12 KOO27921.1 - 2.5e-17 63.1 0.8 2.3e-06 27.9 0.0 3.6 3 0 0 3 3 3 3 Agenet domain Helicase_C PF00271.31 KOO27921.1 - 5.9e-17 62.0 0.0 3.2e-15 56.4 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO27921.1 - 9.7e-08 32.2 0.1 3.8e-07 30.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KOO27921.1 - 6.7e-07 28.8 0.0 1.5e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 KOO27921.1 - 5e-06 26.4 0.0 1.1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase MHC_II_alpha PF00993.20 KOO27921.1 - 0.19 11.4 0.1 0.41 10.4 0.1 1.5 1 0 0 1 1 1 0 Class II histocompatibility antigen, alpha domain zf-RING_2 PF13639.6 KOO27923.1 - 0.26 11.6 10.8 0.64 10.4 10.8 1.7 1 0 0 1 1 1 0 Ring finger domain Pkinase PF00069.25 KOO27924.1 - 5.1e-57 193.2 0.0 6.3e-57 192.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27924.1 - 2.5e-36 125.3 0.0 3.4e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO27924.1 - 0.0019 17.6 0.0 0.0078 15.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO27924.1 - 0.0092 14.8 0.0 0.018 13.8 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KOO27924.1 - 0.12 12.3 1.9 0.39 10.6 0.3 2.2 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kinesin PF00225.23 KOO27926.1 - 2.4e-75 253.5 0.0 4.3e-75 252.7 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO27926.1 - 7.6e-15 55.1 0.0 1.7e-13 50.8 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding DUF4407 PF14362.6 KOO27926.1 - 0.32 10.3 10.8 0.73 9.1 10.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_22 PF13401.6 KOO27926.1 - 2.8 8.2 4.3 1.7 8.9 0.6 2.3 2 0 0 2 2 2 0 AAA domain DUF1690 PF07956.11 KOO27926.1 - 4 7.9 5.5 9 6.7 5.5 1.6 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) EF-hand_7 PF13499.6 KOO27927.1 - 1.3e-37 128.1 17.3 2.1e-12 47.3 1.1 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO27927.1 - 1.6e-33 111.8 28.3 8.3e-07 28.1 0.4 6.4 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO27927.1 - 1.1e-32 109.1 23.8 5.7e-07 29.0 0.6 6.3 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.6 KOO27927.1 - 3.6e-29 99.0 29.4 2e-07 30.2 1.0 6.4 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO27927.1 - 1.5e-25 88.8 24.1 2.9e-08 33.4 0.4 6.2 3 3 3 6 6 6 5 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO27927.1 - 0.00023 21.5 4.1 0.71 10.2 0.2 4.2 2 2 2 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO27927.1 - 0.002 18.4 0.6 37 4.7 0.0 4.3 3 2 0 3 3 3 0 EF-hand domain Phage_TAC_4 PF08748.11 KOO27927.1 - 0.003 17.9 1.3 0.11 12.8 0.4 3.1 2 1 0 2 2 2 1 Phage tail assembly chaperone SopA_C PF13979.6 KOO27927.1 - 0.0074 16.0 0.0 0.26 11.0 0.0 2.8 1 1 1 3 3 3 1 SopA-like catalytic domain DUF1707 PF08044.11 KOO27927.1 - 0.0082 16.2 0.1 3.2 7.9 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF1707) Phage_lysozyme PF00959.19 KOO27927.1 - 0.015 15.7 0.0 2.6 8.5 0.0 3.2 3 0 0 3 3 3 0 Phage lysozyme EF-hand_4 PF12763.7 KOO27927.1 - 0.055 13.4 8.2 9.3 6.3 0.1 4.5 3 2 2 5 5 5 0 Cytoskeletal-regulatory complex EF hand DUF5338 PF17273.2 KOO27927.1 - 0.087 12.9 0.0 7.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5338) Caleosin PF05042.13 KOO27927.1 - 0.1 12.6 5.0 4.9 7.0 0.0 4.2 4 1 0 5 5 5 0 Caleosin related protein Excalibur PF05901.11 KOO27927.1 - 0.17 12.5 8.3 9.2 7.0 0.1 4.7 5 0 0 5 5 5 0 Excalibur calcium-binding domain EF-hand_10 PF14788.6 KOO27927.1 - 4.3 7.3 13.3 20 5.1 0.2 5.2 6 0 0 6 6 6 0 EF hand CRAL_TRIO PF00650.20 KOO27928.1 - 1.3e-29 103.0 0.0 9.6e-15 54.7 0.0 2.2 2 0 0 2 2 2 2 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KOO27928.1 - 0.0046 17.1 0.0 0.055 13.6 0.0 2.2 2 1 0 2 2 2 1 Divergent CRAL/TRIO domain Baculo_p26 PF04766.12 KOO27928.1 - 0.098 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus p26 protein His_Phos_2 PF00328.22 KOO27930.1 - 1.4e-12 47.7 0.0 2.5e-06 27.1 0.0 3.0 3 0 0 3 3 3 3 Histidine phosphatase superfamily (branch 2) TIR_2 PF13676.6 KOO27931.1 - 9.2e-05 23.0 0.0 0.0002 21.9 0.0 1.6 1 0 0 1 1 1 1 TIR domain NAD_binding_1 PF00175.21 KOO27932.1 - 2.4e-16 60.4 0.0 3.2e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain SIS_2 PF13580.6 KOO27932.1 - 0.01 15.8 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 0 SIS domain Flavodoxin_1 PF00258.25 KOO27933.1 - 2.7e-32 111.9 0.0 4.1e-32 111.4 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 KOO27933.1 - 2.2e-10 40.5 0.0 3.4e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_3 PF12641.7 KOO27933.1 - 0.00058 19.6 0.0 0.00085 19.0 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_5 PF12724.7 KOO27933.1 - 0.0025 18.0 0.0 0.0037 17.5 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain polyprenyl_synt PF00348.17 KOO27934.1 - 2.7e-53 180.7 0.0 3.4e-53 180.3 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase UbiA PF01040.18 KOO27934.1 - 0.042 13.1 0.0 0.076 12.3 0.0 1.4 1 0 0 1 1 1 0 UbiA prenyltransferase family HSP70 PF00012.20 KOO27935.1 - 2.3e-265 881.4 10.2 2.7e-265 881.3 10.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOO27935.1 - 1.8e-16 59.9 0.6 7.2e-15 54.6 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 KOO27935.1 - 0.00019 20.8 0.9 0.051 12.8 0.2 2.6 2 1 0 2 2 2 2 Hydantoinase/oxoprolinase FtsA PF14450.6 KOO27935.1 - 0.024 15.0 5.8 1.5 9.3 0.3 3.8 3 2 0 3 3 3 0 Cell division protein FtsA AAA_15 PF13175.6 KOO27935.1 - 0.07 12.8 7.2 0.13 11.9 7.2 1.4 1 0 0 1 1 1 0 AAA ATPase domain HU-CCDC81_bac_2 PF18175.1 KOO27935.1 - 0.11 12.4 3.0 9.7 6.1 0.1 3.1 2 1 1 3 3 3 0 CCDC81-like prokaryotic HU domain 2 GLE1 PF07817.13 KOO27935.1 - 0.32 10.2 0.9 0.9 8.7 0.0 2.0 2 0 0 2 2 2 0 GLE1-like protein FDF PF09532.10 KOO27935.1 - 0.82 10.6 9.7 2.1 9.3 9.7 1.7 1 0 0 1 1 1 0 FDF domain UPF0242 PF06785.11 KOO27935.1 - 3.8 7.6 11.4 11 6.1 11.4 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AAA_11 PF13086.6 KOO27935.1 - 5.5 6.7 10.2 15 5.3 8.6 2.0 2 0 0 2 2 2 0 AAA domain DUF883 PF05957.13 KOO27935.1 - 6.5 7.4 10.7 1.7 9.3 3.3 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) PhyH PF05721.13 KOO27937.1 - 9e-05 22.8 0.0 0.21 11.8 0.0 2.5 2 1 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) STAG PF08514.11 KOO27939.1 - 2.9e-12 46.5 0.3 6.3e-12 45.4 0.2 1.6 2 0 0 2 2 2 1 STAG domain HEAT PF02985.22 KOO27939.1 - 0.00065 19.7 2.1 2 8.9 0.0 4.2 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 KOO27939.1 - 0.021 15.2 3.3 0.67 10.4 0.0 3.7 2 2 0 3 3 3 0 HEAT repeats HECT PF00632.25 KOO27940.1 - 1.5e-46 159.3 0.0 2.9e-46 158.4 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ank_2 PF12796.7 KOO27940.1 - 7.7e-08 32.8 0.0 2e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO27940.1 - 1.8e-07 30.9 0.2 0.13 12.9 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 KOO27940.1 - 7.9e-07 29.5 0.0 0.012 16.2 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO27940.1 - 1.5e-06 28.3 0.2 0.00063 20.0 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO27940.1 - 5.2e-05 23.5 1.8 0.25 11.9 0.2 3.8 3 0 0 3 3 3 2 Ankyrin repeat ZZ PF00569.17 KOO27940.1 - 0.015 15.1 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type Hist_deacetyl PF00850.19 KOO27942.1 - 4.8e-65 220.0 0.1 6.4e-65 219.6 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Stc1 PF12898.7 KOO27942.1 - 0.0016 18.9 0.9 0.0033 17.9 0.9 1.5 1 0 0 1 1 1 1 Stc1 domain zf-RING_2 PF13639.6 KOO27943.1 - 5.6e-06 26.6 7.8 0.013 15.8 1.8 2.7 1 1 1 2 2 2 2 Ring finger domain zf-RING_11 PF17123.5 KOO27943.1 - 0.017 14.9 1.7 0.026 14.3 0.1 2.2 3 0 0 3 3 3 0 RING-like zinc finger zf-C3HC4 PF00097.25 KOO27943.1 - 0.019 14.9 6.7 0.08 12.8 0.8 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO27943.1 - 0.063 13.1 1.1 0.063 13.1 1.1 3.0 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO27943.1 - 1 9.2 7.4 5.2 7.0 0.6 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO27943.1 - 1.6 8.7 6.2 1.7 8.6 0.5 2.6 2 0 0 2 2 2 0 zinc-RING finger domain SMC_N PF02463.19 KOO27944.1 - 8.6e-62 208.4 1.5 1.1e-61 208.1 1.5 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOO27944.1 - 1.4e-20 73.7 0.3 7.7e-20 71.4 0.3 2.3 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KOO27944.1 - 2.4e-09 37.4 0.0 0.00016 21.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KOO27944.1 - 2e-08 34.4 3.9 0.00049 19.9 0.0 3.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 KOO27944.1 - 7.9e-07 29.8 18.5 7.9e-07 29.8 18.5 6.4 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KOO27944.1 - 0.00067 19.4 0.0 0.0015 18.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain UPF0184 PF03670.13 KOO27944.1 - 0.26 11.7 2.2 0.97 9.9 0.3 3.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) OrsD PF12013.8 KOO27944.1 - 3.6 8.1 4.7 15 6.1 0.3 3.5 2 1 1 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D Baculo_F PF12259.8 KOO27944.1 - 4.4 5.7 9.7 15 3.9 9.7 1.9 1 0 0 1 1 1 0 Baculovirus F protein SNF2_N PF00176.23 KOO27945.1 - 5.7e-46 156.8 0.0 2.9e-45 154.5 0.0 1.8 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO27945.1 - 7.2e-19 68.2 0.0 1.2e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 KOO27945.1 - 1.9e-14 53.3 0.0 4.7e-06 26.4 0.0 2.4 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain HDA2-3 PF11496.8 KOO27945.1 - 1.1e-08 34.6 0.0 2e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 KOO27945.1 - 5.2e-05 23.3 0.0 0.00074 19.6 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO27945.1 - 0.00093 19.0 0.0 0.0096 15.7 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 KOO27945.1 - 0.021 14.1 0.1 0.039 13.2 0.1 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 KOO27945.1 - 0.14 11.8 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Cyclin PF08613.11 KOO27946.1 - 8.2e-20 71.8 0.2 1.8e-19 70.7 0.2 1.6 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KOO27946.1 - 0.0012 18.6 0.1 0.0022 17.8 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Med3 PF11593.8 KOO27946.1 - 1.1 8.4 5.5 1.5 8.0 5.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FKBP_C PF00254.28 KOO27947.1 - 1.2e-24 86.4 0.0 2.1e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 KOO27947.1 - 0.017 16.1 0.0 0.034 15.1 0.0 1.5 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Ion_trans PF00520.31 KOO27948.1 - 1.8e-14 53.6 4.6 3e-14 52.9 4.6 1.4 1 0 0 1 1 1 1 Ion transport protein DUF4366 PF14283.6 KOO27949.1 - 0.7 9.9 3.9 1.2 9.1 3.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) RIFIN PF02009.16 KOO27949.1 - 1 9.2 3.8 1.7 8.4 3.8 1.3 1 0 0 1 1 1 0 Rifin SCAB_CC PF16712.5 KOO27949.1 - 1.4 8.8 7.4 2.2 8.1 7.4 1.2 1 0 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein Nodulin-like PF06813.13 KOO27950.1 - 8.9e-09 35.2 8.2 8.9e-09 35.2 8.2 1.7 2 0 0 2 2 2 1 Nodulin-like MFS_1 PF07690.16 KOO27950.1 - 4.1e-06 26.0 49.2 4.1e-06 26.0 49.2 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Pkinase PF00069.25 KOO27951.1 - 7.1e-51 173.1 0.0 8.1e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27951.1 - 1.9e-24 86.4 0.0 2.3e-24 86.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO27951.1 - 0.0014 18.0 0.1 0.0021 17.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO27951.1 - 0.026 13.3 0.0 0.039 12.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 KOO27951.1 - 0.026 13.8 0.1 2.6 7.3 0.0 2.9 2 1 1 3 3 3 0 Kinase-like ADH_zinc_N PF00107.26 KOO27952.1 - 2.4e-21 76.0 0.1 4.3e-21 75.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOO27952.1 - 9.1e-20 70.6 1.4 2e-19 69.4 1.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.19 KOO27952.1 - 0.0069 15.8 0.1 0.012 14.9 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KOO27952.1 - 0.037 13.3 0.4 0.068 12.5 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PEP-CTERM PF07589.11 KOO27952.1 - 0.17 12.0 1.7 0.27 11.4 0.1 2.3 2 0 0 2 2 2 0 PEP-CTERM motif AdoHcyase_NAD PF00670.21 KOO27952.1 - 0.92 9.6 3.4 0.38 10.8 0.7 1.7 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain LRR_6 PF13516.6 KOO27955.1 - 6.8e-121 384.3 214.5 0.00034 20.4 0.3 39.6 39 0 0 39 39 39 37 Leucine Rich repeat LRR_4 PF12799.7 KOO27955.1 - 3.4e-35 119.5 104.2 0.017 15.5 1.7 23.0 17 4 8 26 26 26 18 Leucine Rich repeats (2 copies) DUF3140 PF11338.8 KOO27955.1 - 4.2e-09 36.7 0.8 21 5.6 0.0 9.8 11 0 0 11 11 11 1 Protein of unknown function (DUF3140) LRR_1 PF00560.33 KOO27955.1 - 1.5e-06 27.9 39.0 14 6.7 0.1 22.4 28 3 0 28 28 28 1 Leucine Rich Repeat DUF4030 PF13222.6 KOO27955.1 - 3.3e-06 27.3 2.7 72 3.5 0.0 9.5 11 0 0 11 11 11 0 Protein of unknown function (DUF4030) NACHT PF05729.12 KOO27955.1 - 0.00091 19.2 0.1 0.002 18.1 0.1 1.6 1 0 0 1 1 1 1 NACHT domain PHtD_u1 PF16645.5 KOO27955.1 - 0.054 13.9 17.3 84 3.7 0.0 8.6 9 0 0 9 9 9 0 Unstructured region on Pneumococcal histidine triad protein TraK PF06586.11 KOO27955.1 - 0.059 13.0 0.0 0.059 13.0 0.0 7.9 11 0 0 11 11 11 0 TraK protein COPI_assoc PF08507.10 KOO27956.1 - 4e-11 43.1 6.3 5.7e-11 42.6 6.3 1.1 1 0 0 1 1 1 1 COPI associated protein Cg6151-P PF10233.9 KOO27956.1 - 2.1e-05 24.8 5.6 3.3e-05 24.2 5.6 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Pkinase PF00069.25 KOO27957.1 - 8.3e-24 84.4 0.0 1.4e-23 83.6 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27957.1 - 1.3e-08 34.5 0.0 2.3e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO27957.1 - 0.0003 20.8 1.3 0.00085 19.3 0.1 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KOO27957.1 - 0.0048 16.3 0.0 0.012 15.0 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOO27957.1 - 0.082 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 KOO27957.1 - 0.24 10.1 0.1 0.64 8.7 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase Kinase-like PF14531.6 KOO27957.1 - 0.27 10.5 0.1 1.4 8.2 0.1 2.0 2 1 0 2 2 2 0 Kinase-like SHIPPO-rpt PF07004.12 KOO27958.1 - 0.00063 20.5 4.3 0.019 15.9 0.4 7.3 7 1 0 7 7 7 4 Sperm-tail PG-rich repeat VWA PF00092.28 KOO27959.1 - 2.4e-14 54.0 0.0 3.6e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 KOO27959.1 - 7.3e-13 48.7 0.1 2.2e-12 47.2 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 KOO27959.1 - 3.6e-11 43.7 0.0 7.3e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain OAM_dimer PF16554.5 KOO27960.1 - 0.33 11.4 1.5 0.68 10.4 0.0 2.3 2 0 0 2 2 2 0 Dimerisation domain of d-ornithine 4,5-aminomutase Beta-lactamase PF00144.24 KOO27961.1 - 1.2e-21 77.3 0.0 7.1e-21 74.8 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase EF-hand_1 PF00036.32 KOO27963.1 - 3.2e-31 104.5 5.8 1.1e-06 27.8 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO27963.1 - 3e-28 95.3 5.7 1.3e-07 31.0 0.3 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO27963.1 - 1.5e-26 92.6 3.9 1.7e-13 50.8 0.6 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO27963.1 - 8.3e-20 69.3 5.6 4e-05 22.9 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO27963.1 - 1.1e-19 69.9 8.9 2.8e-09 36.7 0.4 3.8 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 KOO27963.1 - 3.4e-07 30.5 0.3 0.00019 21.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_10 PF14788.6 KOO27963.1 - 9.7e-05 22.1 0.4 0.1 12.5 0.0 2.7 3 0 0 3 3 3 2 EF hand Mlo PF03094.15 KOO27963.1 - 0.003 16.0 9.9 0.16 10.3 0.1 3.4 3 1 0 3 3 3 2 Mlo family SfLAP PF11139.8 KOO27963.1 - 0.013 14.9 1.8 0.038 13.4 1.8 1.8 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein EF-hand_4 PF12763.7 KOO27963.1 - 0.02 14.9 6.0 1.2 9.1 0.3 3.7 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.12 KOO27963.1 - 0.11 12.7 1.6 0.8 9.9 0.2 2.3 1 1 1 2 2 2 0 p25-alpha CitMHS PF03600.16 KOO27963.1 - 0.12 11.6 8.7 0.015 14.6 3.7 1.9 1 1 1 2 2 2 0 Citrate transporter TerB PF05099.13 KOO27963.1 - 4.5 7.2 7.7 3.5 7.6 0.1 3.7 3 1 1 4 4 4 0 Tellurite resistance protein TerB Orai-1 PF07856.12 KOO27964.1 - 3.3e-09 36.7 2.1 5.6e-09 35.9 2.1 1.3 1 0 0 1 1 1 1 Mediator of CRAC channel activity Metal_resist PF13801.6 KOO27964.1 - 0.033 14.4 0.9 0.55 10.4 0.1 2.4 2 0 0 2 2 2 0 Heavy-metal resistance DUF4834 PF16118.5 KOO27964.1 - 0.072 14.1 0.0 0.34 11.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TMEM40 PF15817.5 KOO27964.1 - 0.13 12.1 3.6 0.3 10.8 3.6 1.6 1 0 0 1 1 1 0 Transmembrane protein 40 family DUF3955 PF13127.6 KOO27964.1 - 0.14 12.0 3.1 0.35 10.7 3.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3955) SPC25 PF06703.11 KOO27964.1 - 0.16 11.8 4.7 2.7 7.7 1.4 2.1 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF3021 PF11457.8 KOO27964.1 - 0.55 10.6 12.4 0.22 11.9 8.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) Choline_transpo PF04515.12 KOO27965.1 - 2.8e-64 217.4 35.1 2.8e-64 217.4 35.1 2.8 3 0 0 3 3 3 2 Plasma-membrane choline transporter DUF4519 PF15012.6 KOO27965.1 - 2.1 8.6 4.2 6.1 7.1 0.7 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Thioredoxin PF00085.20 KOO27966.1 - 1.1e-19 70.3 0.0 1.4e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOO27966.1 - 0.0067 16.9 0.3 0.44 11.0 0.3 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 KOO27966.1 - 0.02 14.7 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 KOO27966.1 - 0.036 14.4 0.0 0.19 12.1 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_3 PF13192.6 KOO27966.1 - 0.17 11.9 0.0 0.45 10.6 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin domain TMF_TATA_bd PF12325.8 KOO27967.1 - 0.0026 17.9 20.2 0.046 13.9 2.5 4.3 2 1 2 4 4 4 1 TATA element modulatory factor 1 TATA binding Bap31_Bap29_C PF18035.1 KOO27967.1 - 0.0028 17.6 8.3 0.28 11.2 0.1 3.6 3 0 0 3 3 3 2 Bap31/Bap29 cytoplasmic coiled-coil domain DUF3450 PF11932.8 KOO27967.1 - 0.0038 16.6 3.7 0.0038 16.6 3.7 3.2 1 1 2 3 3 3 1 Protein of unknown function (DUF3450) DUF4618 PF15397.6 KOO27967.1 - 0.0053 16.2 8.9 0.0053 16.2 8.9 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4618) FAM76 PF16046.5 KOO27967.1 - 0.039 13.3 11.7 0.032 13.6 6.1 2.2 2 0 0 2 2 2 0 FAM76 protein Spc7 PF08317.11 KOO27967.1 - 0.096 11.5 21.7 0.012 14.6 10.3 2.4 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF3584 PF12128.8 KOO27967.1 - 0.11 9.9 19.9 0.12 9.9 8.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) BAR_2 PF10455.9 KOO27967.1 - 0.12 11.5 8.7 0.015 14.5 4.1 1.7 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking BLOC1_2 PF10046.9 KOO27967.1 - 0.13 12.6 10.4 0.16 12.3 0.4 3.5 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-F_leu_zip PF10473.9 KOO27967.1 - 0.16 12.0 21.6 0.47 10.5 10.9 3.1 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 KOO27967.1 - 0.16 12.3 8.9 10 6.6 0.4 4.1 3 1 0 4 4 4 0 Flagella accessory protein C (FlaC) CALCOCO1 PF07888.11 KOO27967.1 - 0.57 9.0 23.3 2.4 7.0 23.3 1.8 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Fez1 PF06818.15 KOO27967.1 - 0.7 10.3 20.2 2.4 8.6 10.3 2.5 1 1 1 2 2 2 0 Fez1 CCDC-167 PF15188.6 KOO27967.1 - 0.88 10.0 17.0 0.55 10.6 7.3 3.9 3 2 0 3 3 3 0 Coiled-coil domain-containing protein 167 Golgin_A5 PF09787.9 KOO27967.1 - 1.9 7.9 21.0 2.7 7.4 14.1 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF5082 PF16888.5 KOO27967.1 - 2.2 8.6 9.5 0.36 11.1 0.5 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF5082) Spore_III_AB PF09548.10 KOO27967.1 - 2.5 8.2 8.0 0.39 10.8 3.0 2.1 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Lectin_N PF03954.14 KOO27967.1 - 2.7 7.8 7.9 42 3.9 4.8 3.3 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain ADIP PF11559.8 KOO27967.1 - 3.2 7.8 17.4 0.19 11.8 10.2 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 KOO27967.1 - 4.4 7.9 23.2 1.6e+04 -3.6 22.4 3.4 1 1 0 1 1 0 0 Apg6 coiled-coil region V_ATPase_I PF01496.19 KOO27967.1 - 4.4 5.1 10.8 1 7.2 6.9 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family LPP PF04728.13 KOO27967.1 - 4.7 7.7 0.0 4.7 7.7 0.0 5.1 6 1 0 6 6 4 0 Lipoprotein leucine-zipper Prominin PF05478.11 KOO27967.1 - 5.5 4.8 7.0 11 3.8 1.3 2.0 1 1 0 2 2 2 0 Prominin Macoilin PF09726.9 KOO27967.1 - 5.5 5.4 20.1 79 1.6 17.7 2.8 1 1 1 2 2 2 0 Macoilin family TTL PF03133.15 KOO27968.1 - 1.7e-48 165.2 0.0 1.5e-35 122.8 0.0 2.1 1 1 1 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO27968.1 - 5.8e-07 29.0 0.0 0.0004 19.7 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO27968.1 - 2.7e-05 23.5 0.0 0.0073 15.6 0.0 2.1 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 KOO27968.1 - 0.013 15.5 0.0 0.3 11.1 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.11 KOO27968.1 - 0.055 13.1 0.0 2.2 7.8 0.0 2.2 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Arm PF00514.23 KOO27969.1 - 3.1e-118 382.7 83.3 3.5e-06 26.8 0.0 26.3 27 0 0 27 27 27 22 Armadillo/beta-catenin-like repeat Clathrin_propel PF01394.20 KOO27969.1 - 5.8e-32 108.4 3.4 0.0002 21.5 0.0 6.8 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 KOO27969.1 - 9.1e-28 96.0 0.1 3.1e-27 94.3 0.1 2.0 1 0 0 1 1 1 1 Clathrin-H-link HEAT_2 PF13646.6 KOO27969.1 - 3.5e-23 81.8 35.7 5.4e-14 52.3 4.2 13.4 2 2 12 16 16 15 3 HEAT repeats HEAT PF02985.22 KOO27969.1 - 3e-18 64.3 49.1 0.00013 21.9 0.1 14.4 15 1 1 16 16 16 6 HEAT repeat Cnd1 PF12717.7 KOO27969.1 - 8.1e-11 42.2 5.9 0.087 12.9 0.0 7.2 4 1 2 7 7 7 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KOO27969.1 - 2.4e-08 34.3 11.5 2.8e-06 27.7 2.0 16.1 13 5 6 19 19 19 7 HEAT-like repeat Clathrin-link PF09268.10 KOO27969.1 - 2.5e-08 33.1 0.0 5e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Clathrin, heavy-chain linker RTP1_C1 PF10363.9 KOO27969.1 - 1.7e-07 31.4 0.3 0.071 13.3 0.0 5.3 4 1 2 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 KOO27969.1 - 8.2e-07 27.9 7.4 0.00072 18.2 0.3 3.0 2 1 1 3 3 3 2 Adaptin N terminal region CLASP_N PF12348.8 KOO27969.1 - 0.0098 15.5 2.1 20 4.6 0.0 4.6 1 1 4 5 5 5 0 CLASP N terminal Nipped-B_C PF12830.7 KOO27969.1 - 0.01 15.8 3.9 4.3 7.2 0.2 4.2 2 1 3 5 5 5 0 Sister chromatid cohesion C-terminus Phage_holin_6_1 PF09682.10 KOO27970.1 - 0.59 10.6 3.5 0.23 11.9 0.5 1.7 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Clathrin PF00637.20 KOO27971.1 - 2.4e-183 601.3 37.4 4.1e-30 104.6 1.8 7.7 8 0 0 8 8 8 7 Region in Clathrin and VPS Coatomer_WDAD PF04053.14 KOO27971.1 - 0.00072 18.7 1.8 0.31 10.0 0.2 2.8 2 0 0 2 2 2 2 Coatomer WD associated region DUF1400 PF07176.11 KOO27971.1 - 0.016 15.5 4.1 7.5 6.8 0.1 4.4 4 0 0 4 4 4 0 Alpha/beta hydrolase of unknown function (DUF1400) MerR PF00376.23 KOO27971.1 - 0.028 14.2 0.0 0.058 13.2 0.0 1.6 1 0 0 1 1 1 0 MerR family regulatory protein tRNA_int_end_N2 PF12928.7 KOO27971.1 - 0.13 12.5 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 tRNA-splicing endonuclease subunit sen54 N-term TPR_1 PF00515.28 KOO27971.1 - 0.21 11.5 10.4 7.5 6.6 0.0 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TruD PF01142.18 KOO27972.1 - 2.6e-58 197.8 0.0 1.2e-56 192.4 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Paf1 PF03985.13 KOO27972.1 - 2.4 7.1 5.3 3.6 6.5 5.3 1.1 1 0 0 1 1 1 0 Paf1 SelK_SelG PF10961.8 KOO27972.1 - 4 8.1 9.4 1.4 9.6 1.6 2.6 2 0 0 2 2 2 0 Selenoprotein SelK_SelG LRR_1 PF00560.33 KOO27973.1 - 1.8e-05 24.7 0.2 5.4 8.0 0.0 4.4 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 KOO27973.1 - 2.9e-05 23.8 7.8 0.44 10.7 0.0 5.5 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.7 KOO27973.1 - 0.00013 22.3 0.0 0.37 11.3 0.0 3.4 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) RCC1_2 PF13540.6 KOO27974.1 - 1.4e-10 40.7 21.2 0.0036 17.0 0.2 6.2 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 KOO27974.1 - 2.5e-08 33.7 0.1 2.5e-08 33.7 0.1 1.9 2 0 0 2 2 2 1 F-box-like RCC1 PF00415.18 KOO27974.1 - 2.1e-07 31.5 27.4 0.00041 20.9 0.1 7.6 7 2 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat F-box PF00646.33 KOO27974.1 - 1.2e-05 25.1 0.0 1.2e-05 25.1 0.0 2.5 2 0 0 2 2 2 1 F-box domain DEAD PF00270.29 KOO27974.1 - 0.0051 16.6 0.0 0.016 15.0 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 KOO27974.1 - 0.009 15.6 0.2 0.056 13.0 0.1 2.0 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 KOO27974.1 - 0.011 15.5 0.1 0.036 13.9 0.1 1.9 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain ResIII PF04851.15 KOO27974.1 - 0.013 15.5 0.0 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.16 KOO27974.1 - 0.016 14.6 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Kelch_4 PF13418.6 KOO27974.1 - 2.8 8.0 4.5 1.9 8.5 0.4 2.8 2 0 0 2 2 2 0 Galactose oxidase, central domain NAD_binding_5 PF07994.12 KOO27975.1 - 6.9e-142 472.6 0.0 8.5e-142 472.3 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 KOO27975.1 - 2.6e-47 159.6 0.7 5.6e-47 158.5 0.4 1.8 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase polyprenyl_synt PF00348.17 KOO27976.1 - 1.2e-23 83.5 0.0 1.7e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase HU-CCDC81_euk_1 PF14908.6 KOO27976.1 - 2.2e-07 30.9 0.0 4.5e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 1 HU-CCDC81_euk_2 PF18289.1 KOO27976.1 - 1.6e-06 28.2 0.0 3.3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 Cyt-b5 PF00173.28 KOO27977.1 - 0.00016 21.8 0.1 0.00027 21.0 0.1 1.5 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ank_5 PF13857.6 KOO27978.1 - 7.9e-10 38.8 1.3 0.00071 19.8 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO27978.1 - 4.5e-09 36.7 0.3 0.0046 17.5 0.0 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO27978.1 - 7.8e-08 32.8 0.9 3.6e-07 30.7 0.2 2.2 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO27978.1 - 1.3e-05 25.2 2.1 0.65 10.8 0.0 4.3 4 1 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOO27978.1 - 6.6e-05 23.2 15.1 0.044 14.3 0.1 4.9 5 1 0 5 5 5 2 Ankyrin repeat BKACE PF05853.12 KOO27978.1 - 0.025 13.9 0.1 0.028 13.7 0.1 1.2 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme End3 PF12761.7 KOO27979.1 - 0.03 14.5 0.8 0.041 14.0 0.8 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Lipoprotein_15 PF03640.15 KOO27979.1 - 0.13 11.8 1.4 0.24 11.0 0.5 1.9 2 0 0 2 2 2 0 Secreted repeat of unknown function CENP-T_C PF15511.6 KOO27980.1 - 1.2e-08 35.1 0.1 1.4e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KOO27980.1 - 0.00011 22.5 0.1 0.00014 22.1 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 KOO27980.1 - 0.00016 21.7 0.2 0.00023 21.3 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 KOO27980.1 - 0.00069 19.9 0.1 0.0011 19.1 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOO27980.1 - 0.00077 19.8 0.3 0.00086 19.7 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 KOO27980.1 - 0.0088 16.1 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KOO27980.1 - 0.0098 15.9 0.1 0.015 15.3 0.1 1.2 1 0 0 1 1 1 1 Bromodomain associated UPF0137 PF03677.13 KOO27980.1 - 0.16 11.7 0.1 0.2 11.4 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Sec34 PF04136.15 KOO27981.1 - 0.00047 20.1 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 Sec34-like family EF-hand_1 PF00036.32 KOO27982.1 - 0.0035 16.8 0.1 0.014 14.9 0.0 2.0 2 0 0 2 2 2 1 EF hand DUF2475 PF10629.9 KOO27982.1 - 0.0045 17.2 3.2 1.2 9.4 1.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) EF-hand_5 PF13202.6 KOO27982.1 - 0.013 15.0 0.1 0.013 15.0 0.1 1.8 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 KOO27982.1 - 0.046 13.7 0.1 0.18 11.8 0.1 2.0 2 0 0 2 2 2 0 EF-hand domain ubiquitin PF00240.23 KOO27983.1 - 0.00022 20.9 0.1 0.00028 20.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family T2SSppdC PF12528.8 KOO27984.1 - 0.38 11.6 6.5 0.62 10.9 6.5 1.3 1 0 0 1 1 1 0 Type II secretion prepilin peptidase dependent protein C ELM2 PF01448.24 KOO27985.1 - 9.8e-05 23.0 0.1 0.00057 20.6 0.0 2.2 3 0 0 3 3 3 1 ELM2 domain zf-RanBP PF00641.18 KOO27986.1 - 1.9e-08 33.4 3.3 1.9e-08 33.4 3.3 2.3 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others DZR PF12773.7 KOO27986.1 - 0.26 11.3 6.6 1 9.4 2.9 2.7 2 0 0 2 2 2 0 Double zinc ribbon XK-related PF09815.9 KOO27988.1 - 0.0042 16.2 11.3 0.019 14.0 11.2 1.9 1 1 0 1 1 1 1 XK-related protein SinI PF08671.10 KOO27988.1 - 0.0064 16.2 0.1 0.018 14.8 0.1 1.9 1 0 0 1 1 1 1 Anti-repressor SinI Aa_trans PF01490.18 KOO27991.1 - 4.3e-24 85.0 8.5 1.2e-23 83.6 8.5 1.5 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein FHA PF00498.26 KOO27992.1 - 3e-28 98.0 0.2 1.6e-14 54.0 0.0 2.3 2 0 0 2 2 2 2 FHA domain Yop-YscD_cpl PF16697.5 KOO27992.1 - 9.1e-24 83.6 0.0 2e-11 44.0 0.0 2.3 2 0 0 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain Arm PF00514.23 KOO27993.1 - 0.00091 19.2 6.2 14 5.9 0.0 6.1 6 1 1 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KOO27993.1 - 0.018 15.3 2.8 69 4.1 0.0 5.0 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 KOO27993.1 - 0.055 14.0 8.0 0.08 13.5 0.2 4.6 4 0 0 4 4 4 0 HEAT-like repeat Apt1 PF10351.9 KOO27993.1 - 3.1 6.5 5.3 4.7 6.0 5.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pkinase PF00069.25 KOO27994.1 - 1.5e-62 211.3 0.0 8.2e-52 176.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO27994.1 - 1.9e-25 89.6 0.2 8e-21 74.5 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOO27994.1 - 8.9e-05 21.9 0.6 0.00071 19.0 0.6 2.4 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOO27994.1 - 0.00022 20.3 0.2 0.00034 19.7 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOO27994.1 - 0.013 15.4 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family UCH PF00443.29 KOO27995.1 - 7.9e-13 48.5 0.0 1.4e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 KOO27995.1 - 2.1e-08 33.8 0.0 3.9e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 KOO27995.1 - 0.0013 18.6 1.8 0.0019 18.1 0.1 2.2 2 0 0 2 2 2 1 UBA/TS-N domain Homeodomain PF00046.29 KOO27997.1 - 4.3e-13 48.9 0.5 4.3e-13 48.9 0.5 2.0 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 KOO27997.1 - 4.5e-05 23.3 0.0 0.00015 21.5 0.0 1.9 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 KOO27997.1 - 0.051 13.5 0.1 0.099 12.5 0.1 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Homez PF11569.8 KOO27997.1 - 0.065 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez SCP2_2 PF13530.6 KOO27999.1 - 0.13 12.7 0.2 0.28 11.6 0.2 1.6 1 1 0 1 1 1 0 Sterol carrier protein domain MgsA_C PF12002.8 KOO28000.1 - 0.015 15.3 0.1 0.019 14.9 0.1 1.2 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal EF-hand_5 PF13202.6 KOO28001.1 - 6.3e-06 25.4 0.2 1.3e-05 24.5 0.2 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO28001.1 - 4.8e-05 22.6 0.1 9.3e-05 21.7 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO28001.1 - 0.001 18.8 0.0 0.0023 17.7 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO28001.1 - 0.0094 16.4 0.0 0.02 15.3 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair Chloroa_b-bind PF00504.21 KOO28002.1 - 1.1e-29 104.1 0.1 1.5e-29 103.6 0.1 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Ion_trans PF00520.31 KOO28003.1 - 6.8e-77 258.0 28.9 1.2e-50 172.0 10.9 2.0 2 0 0 2 2 2 2 Ion transport protein Lustrin_cystein PF14625.6 KOO28003.1 - 0.0057 17.0 0.7 0.012 16.0 0.7 1.4 1 0 0 1 1 1 1 Lustrin, cysteine-rich repeated domain Ctr PF04145.15 KOO28003.1 - 0.036 14.7 0.1 0.25 12.0 0.1 2.4 1 1 0 1 1 1 0 Ctr copper transporter family ABC1 PF03109.16 KOO28004.1 - 5.8e-19 68.4 0.4 3.9e-09 36.7 0.1 2.4 2 0 0 2 2 2 2 ABC1 family Beta-lactamase PF00144.24 KOO28004.1 - 6.5e-16 58.5 0.1 2.4e-15 56.6 0.1 1.9 1 1 0 1 1 1 1 Beta-lactamase SCP2 PF02036.17 KOO28004.1 - 4.7e-07 30.2 0.0 1.1e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family PX PF00787.24 KOO28004.1 - 5.8e-06 26.3 0.0 1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 PX domain Flg_hook PF02120.16 KOO28004.1 - 0.013 15.3 0.2 0.036 14.0 0.2 1.7 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Alkyl_sulf_C PF14864.6 KOO28004.1 - 0.014 15.7 0.0 0.032 14.5 0.0 1.6 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal LRR_6 PF13516.6 KOO28005.1 - 5.4e-37 122.7 15.5 0.00033 20.5 0.0 8.8 8 0 0 8 8 8 7 Leucine Rich repeat BRCT PF00533.26 KOO28005.1 - 2.5e-07 31.0 0.0 7.8e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LRR_4 PF12799.7 KOO28005.1 - 8.9e-06 26.0 2.5 6.7 7.3 0.0 5.5 3 1 4 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO28005.1 - 0.0025 17.5 4.0 13 5.6 0.1 5.3 2 2 3 5 5 5 3 Leucine rich repeat DUF4404 PF14357.6 KOO28005.1 - 0.11 13.1 4.1 0.28 11.8 4.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) PIEZO PF15917.5 KOO28005.1 - 0.17 11.4 0.2 0.37 10.2 0.2 1.5 1 0 0 1 1 1 0 Piezo MAD PF05557.13 KOO28005.1 - 0.56 8.5 6.5 0.81 8.0 6.5 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein AAA_13 PF13166.6 KOO28005.1 - 0.85 8.2 2.2 1.3 7.6 2.2 1.1 1 0 0 1 1 1 0 AAA domain Fea1 PF07692.11 KOO28007.1 - 1.8e-15 56.9 0.1 8.6e-15 54.6 0.1 2.0 1 1 0 1 1 1 1 Low iron-inducible periplasmic protein DUF2909 PF11137.8 KOO28007.1 - 0.016 15.1 0.7 0.034 14.1 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) DUF2568 PF10823.8 KOO28007.1 - 0.18 12.1 3.7 0.37 11.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2568) EF-hand_1 PF00036.32 KOO28008.1 - 2e-23 80.2 8.8 3.5e-08 32.4 0.0 4.7 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 KOO28008.1 - 4e-19 68.8 1.4 7.3e-10 39.2 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO28008.1 - 2.9e-16 57.9 7.9 6.2e-05 22.6 0.1 5.0 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 KOO28008.1 - 6.1e-15 54.8 4.3 1.1e-06 28.3 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO28008.1 - 1.2e-12 46.8 0.4 0.0016 17.8 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KOO28008.1 - 4.3e-07 30.2 0.2 0.011 16.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO28008.1 - 1.3e-06 28.3 1.3 0.017 15.0 0.1 3.2 3 1 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 KOO28008.1 - 0.0042 17.1 0.1 0.15 12.0 0.0 2.6 3 0 0 3 3 3 1 Tellurite resistance protein TerB DUF5580 PF17743.1 KOO28008.1 - 0.041 12.4 0.0 0.064 11.8 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5580) SPARC_Ca_bdg PF10591.9 KOO28008.1 - 0.16 12.3 0.0 16 5.9 0.0 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region HTH_26 PF13443.6 KOO28008.1 - 0.18 12.3 0.0 7.9 7.0 0.0 2.5 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain S_100 PF01023.19 KOO28008.1 - 1 9.1 3.4 0.35 10.6 0.2 1.9 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain Ion_trans PF00520.31 KOO28009.1 - 1.7e-101 338.6 4.5 1.4e-45 155.5 3.0 4.1 3 1 1 4 4 4 4 Ion transport protein DUF1180 PF06679.12 KOO28009.1 - 0.25 11.7 7.0 2.9 8.3 2.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) TMF_TATA_bd PF12325.8 KOO28010.1 - 0.91 9.8 17.4 0.67 10.2 9.0 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding KASH_CCD PF14662.6 KOO28010.1 - 3.1 7.6 18.4 2.3 8.0 16.8 1.6 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Borrelia_P83 PF05262.11 KOO28010.1 - 7.3 5.0 12.5 5.3 5.4 10.7 1.5 1 1 0 1 1 1 0 Borrelia P83/100 protein FapA PF03961.13 KOO28010.1 - 7.5 5.0 6.5 2.3 6.7 2.7 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A V_ATPase_I PF01496.19 KOO28010.1 - 7.8 4.3 5.1 9.4 4.0 5.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sec2p PF06428.11 KOO28013.1 - 0.024 14.6 0.5 0.024 14.6 0.5 2.3 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p ATP-synt_D PF01813.17 KOO28013.1 - 0.076 12.8 5.9 0.12 12.2 5.9 1.4 1 1 0 1 1 1 0 ATP synthase subunit D YebO PF13974.6 KOO28013.1 - 0.19 11.8 4.5 0.16 12.0 1.0 2.3 2 0 0 2 2 2 0 YebO-like protein DUF3752 PF12572.8 KOO28013.1 - 0.2 12.2 2.0 0.26 11.8 1.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3752) Exonuc_VII_L PF02601.15 KOO28013.1 - 2.8 7.4 7.4 4 6.9 7.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit ART PF01129.18 KOO28014.1 - 4.7e-05 22.8 0.0 0.00013 21.4 0.0 1.7 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_6 PF13516.6 KOO28014.1 - 0.0013 18.6 0.3 0.13 12.4 0.0 2.9 2 0 0 2 2 2 1 Leucine Rich repeat DUF4407 PF14362.6 KOO28014.1 - 0.011 15.1 9.5 0.028 13.8 9.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1501 PF07394.12 KOO28014.1 - 0.063 12.3 5.7 0.17 10.9 5.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1501) OmpH PF03938.14 KOO28014.1 - 1.2 9.4 11.1 4.5 7.6 11.1 2.0 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 KOO28014.1 - 3.2 7.2 6.8 6.6 6.2 6.8 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMF_TATA_bd PF12325.8 KOO28014.1 - 4 7.7 10.4 21 5.4 0.4 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Ank_2 PF12796.7 KOO28015.1 - 9.3e-20 71.0 0.0 6.7e-09 36.2 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO28015.1 - 2.7e-16 59.7 0.0 5.6e-09 36.4 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO28015.1 - 9.2e-15 54.5 3.6 1.3e-09 38.1 0.1 3.3 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO28015.1 - 1.2e-14 54.0 0.2 1.1e-05 25.6 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 KOO28015.1 - 8.3e-13 47.3 0.0 0.002 18.5 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat DUF2384 PF09722.10 KOO28015.1 - 0.05 13.6 0.6 0.29 11.2 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2384) RskA PF10099.9 KOO28015.1 - 0.095 13.0 25.3 0.17 12.1 25.3 1.5 1 0 0 1 1 1 0 Anti-sigma-K factor rskA PmbA_TldD PF01523.16 KOO28015.1 - 1.1 9.0 6.0 1.7 8.4 6.0 1.4 1 0 0 1 1 1 0 Putative modulator of DNA gyrase Mu-like_Pro PF10123.9 KOO28015.1 - 2.1 7.8 18.1 1.1 8.8 16.2 1.4 2 0 0 2 2 2 0 Mu-like prophage I protein CCDC53 PF10152.9 KOO28015.1 - 8.6 6.8 6.1 17 5.8 6.1 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex KH_1 PF00013.29 KOO28016.1 - 3.9e-21 74.6 0.0 1.4e-10 40.8 0.0 2.2 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 KOO28016.1 - 7.8e-06 25.6 0.0 0.0028 17.4 0.0 2.2 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 KOO28016.1 - 0.00012 21.9 0.3 0.63 9.9 0.0 2.4 2 0 0 2 2 2 2 KH domain G-patch PF01585.23 KOO28017.1 - 8.9e-05 22.3 3.1 8.9e-05 22.3 3.1 1.8 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 KOO28017.1 - 0.0049 16.9 0.1 0.014 15.5 0.1 1.9 1 0 0 1 1 1 1 G-patch domain DUF3486 PF11985.8 KOO28017.1 - 0.27 11.6 0.2 0.27 11.6 0.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3486) Mito_carr PF00153.27 KOO28018.1 - 4.1e-58 193.3 1.4 5.2e-18 64.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_5 PF13202.6 KOO28019.1 - 4.3e-09 35.5 0.2 9.4e-05 21.7 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO28019.1 - 6.1e-09 36.2 0.1 3.1e-08 33.9 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO28019.1 - 5.2e-08 32.2 0.0 5.1e-05 22.9 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO28019.1 - 1.2e-07 30.7 0.1 2.5e-05 23.5 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO28019.1 - 8.8e-07 28.7 0.1 2.4e-06 27.3 0.1 1.8 1 1 0 1 1 1 1 EF-hand domain pair ATP_sub_h PF10775.9 KOO28019.1 - 0.19 11.7 0.4 0.4 10.7 0.4 1.5 1 0 0 1 1 1 0 ATP synthase complex subunit h SHIPPO-rpt PF07004.12 KOO28019.1 - 0.46 11.5 3.5 0.31 12.0 0.3 2.4 2 0 0 2 2 2 0 Sperm-tail PG-rich repeat Ras PF00071.22 KOO28020.1 - 4.4e-53 179.2 0.3 1.6e-52 177.4 0.3 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KOO28020.1 - 6.7e-29 100.5 0.1 9e-28 96.9 0.1 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO28020.1 - 1.5e-07 31.0 0.1 6.6e-07 28.9 0.1 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO28020.1 - 8.8e-06 25.8 0.0 1.5e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO28020.1 - 0.00015 21.7 0.5 0.031 14.2 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 KOO28020.1 - 0.016 15.5 0.1 0.15 12.3 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO28020.1 - 0.051 14.0 0.0 0.11 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 KOO28020.1 - 0.054 14.0 0.0 0.099 13.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 KOO28020.1 - 0.055 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 KOO28020.1 - 0.065 13.0 0.0 0.086 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system TniB PF05621.11 KOO28020.1 - 0.094 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_28 PF13521.6 KOO28020.1 - 0.1 12.8 0.0 1.5 9.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 KOO28020.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MCM PF00493.23 KOO28020.1 - 0.13 11.3 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain FeoB_N PF02421.18 KOO28020.1 - 0.16 11.5 0.1 1.1 8.7 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B Cation_efflux PF01545.21 KOO28021.1 - 1.5e-43 148.8 10.1 2e-43 148.5 10.1 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 KOO28021.1 - 2.7e-18 65.8 2.2 1.4e-14 53.9 0.2 2.2 2 0 0 2 2 2 2 Dimerisation domain of Zinc Transporter AsnC_trans_reg PF01037.21 KOO28021.1 - 0.14 12.1 2.1 0.97 9.5 0.3 2.4 2 0 0 2 2 2 0 Lrp/AsnC ligand binding domain His_Phos_1 PF00300.22 KOO28023.1 - 0.0023 17.7 0.0 0.0028 17.4 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Mito_carr PF00153.27 KOO28024.1 - 4.5e-24 84.2 1.9 4e-11 42.7 0.0 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein Proteasome PF00227.26 KOO28025.1 - 2e-59 200.3 0.1 3.1e-59 199.6 0.0 1.3 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 KOO28025.1 - 4.2e-10 39.1 1.4 4.9e-10 38.9 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature TPR_11 PF13414.6 KOO28026.1 - 0.00079 19.1 3.1 0.04 13.6 0.2 3.1 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 KOO28026.1 - 0.0057 16.7 9.3 0.1 12.8 1.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28026.1 - 0.0088 15.8 16.8 0.0092 15.8 1.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28026.1 - 0.011 15.9 3.3 0.67 10.3 0.2 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MLTR_LBD PF17765.1 KOO28026.1 - 0.017 15.2 10.9 0.95 9.6 4.6 2.3 2 0 0 2 2 2 0 MmyB-like transcription regulator ligand binding domain TPR_17 PF13431.6 KOO28026.1 - 0.055 13.9 0.9 1.3 9.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat MscS_TM PF12794.7 KOO28026.1 - 0.17 10.7 1.9 0.22 10.3 0.0 1.9 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 TPR_16 PF13432.6 KOO28026.1 - 0.41 11.3 0.1 0.41 11.3 0.1 4.5 4 2 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28026.1 - 3.5 8.2 11.5 0.26 11.8 0.4 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.25 KOO28027.1 - 4.1e-49 167.3 0.0 6.3e-49 166.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28027.1 - 1.9e-41 142.1 0.0 2.6e-41 141.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PRIMA1 PF16101.5 KOO28027.1 - 0.00012 22.1 1.1 0.00037 20.5 1.1 1.8 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 Pkinase_fungal PF17667.1 KOO28027.1 - 0.0012 17.7 0.0 0.0022 16.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO28027.1 - 0.051 12.9 0.0 0.083 12.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO28027.1 - 0.12 12.3 0.1 0.51 10.2 0.1 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family HNH_5 PF14279.6 KOO28028.1 - 0.0073 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 HNH endonuclease HNH PF01844.23 KOO28028.1 - 0.022 14.9 0.0 0.036 14.2 0.0 1.3 1 0 0 1 1 1 0 HNH endonuclease DNA_topoisoIV PF00521.20 KOO28029.1 - 5.6e-21 74.9 0.0 8.3e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KOO28029.1 - 5e-13 49.4 0.0 8.3e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM SAP PF02037.27 KOO28029.1 - 1.7e-12 46.8 0.1 3.5e-12 45.8 0.1 1.6 1 0 0 1 1 1 1 SAP domain HATPase_c PF02518.26 KOO28029.1 - 1.5e-10 41.6 0.0 2.3e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_gyraseB PF00204.25 KOO28029.1 - 9.7e-06 25.2 0.0 1.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.22 KOO28029.1 - 0.0011 19.2 0.0 0.0052 17.0 0.0 2.0 1 1 0 1 1 1 1 Toprim domain HeH PF12949.7 KOO28029.1 - 0.0096 15.6 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 HeH/LEM domain DUF4952 PF16310.5 KOO28029.1 - 0.2 11.9 0.0 0.48 10.7 0.0 1.5 1 0 0 1 1 1 0 Domian of unknown function (DUF4952) FAM199X PF15814.5 KOO28030.1 - 0.19 10.8 2.5 0.29 10.2 2.5 1.2 1 0 0 1 1 1 0 Protein family FAM199X Pkinase PF00069.25 KOO28031.1 - 2.2e-50 171.5 0.0 3.1e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28031.1 - 1.1e-43 149.5 0.0 1.8e-43 148.7 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO28031.1 - 0.0016 17.3 0.0 0.0031 16.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO28031.1 - 0.0063 15.9 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO28031.1 - 0.0083 16.1 0.1 0.28 11.1 0.1 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family zf-C3HC4_3 PF13920.6 KOO28032.1 - 2.4e-13 49.7 9.0 3.6e-13 49.1 9.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO28032.1 - 9.3e-06 25.9 9.9 1.5e-05 25.2 9.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOO28032.1 - 1.3e-05 24.9 8.2 2.2e-05 24.2 8.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 KOO28032.1 - 2.1e-05 24.0 0.0 2.8e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Prok-RING_4 PF14447.6 KOO28032.1 - 5.1e-05 23.1 8.0 9e-05 22.3 8.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KOO28032.1 - 0.00068 19.4 9.3 0.0014 18.4 9.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO28032.1 - 0.049 13.6 9.6 0.087 12.8 9.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Baculo_IE-1 PF05290.11 KOO28032.1 - 0.44 10.5 2.5 0.68 9.9 2.5 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_UBOX PF13445.6 KOO28032.1 - 0.92 9.6 7.1 2.2 8.4 7.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger SdiA-regulated PF06977.11 KOO28033.1 - 2.3e-24 86.0 0.0 1.6e-23 83.2 0.0 2.2 1 1 0 1 1 1 1 SdiA-regulated LTD PF00932.19 KOO28033.1 - 3.4e-14 53.1 0.0 3.4e-07 30.6 0.0 2.7 2 0 0 2 2 2 2 Lamin Tail Domain Phytase-like PF13449.6 KOO28033.1 - 0.0045 17.0 0.0 2.1 8.2 0.0 2.4 1 1 1 2 2 2 2 Esterase-like activity of phytase SGL PF08450.12 KOO28033.1 - 0.091 12.3 0.0 10 5.6 0.0 2.9 2 1 1 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Methyltr_RsmB-F PF01189.17 KOO28034.1 - 1.7e-19 70.2 0.0 3.4e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Cyt-b5 PF00173.28 KOO28034.1 - 3.7e-12 46.2 0.0 6.8e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain F-box-like PF12937.7 KOO28034.1 - 0.002 18.0 0.2 0.0038 17.1 0.2 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOO28034.1 - 0.0095 15.8 0.1 0.015 15.1 0.1 1.4 1 0 0 1 1 1 1 F-box domain UBM PF14377.6 KOO28034.1 - 0.01 15.3 0.2 0.021 14.2 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin binding region TPD PF14811.6 KOO28037.1 - 2.6e-44 150.4 0.0 1.6e-43 147.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function TPD sequence-motif AMMECR1 PF01871.17 KOO28038.1 - 6e-39 133.3 0.0 8.7e-39 132.8 0.0 1.2 1 0 0 1 1 1 1 AMMECR1 RRM_1 PF00076.22 KOO28039.1 - 3.1e-18 65.3 0.0 4.5e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 KOO28039.1 - 2.2e-05 23.9 9.0 3.5e-05 23.3 9.0 1.3 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.5 KOO28039.1 - 0.0011 19.1 0.0 0.0034 17.5 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif partial_CstF PF15861.5 KOO28039.1 - 0.0059 16.4 0.5 0.0089 15.8 0.5 1.3 1 0 0 1 1 1 1 Partial cleavage stimulation factor domain PHM7_cyt PF14703.6 KOO28039.1 - 0.018 15.3 0.0 3 8.0 0.0 2.1 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter MDMPI_N PF11716.8 KOO28039.1 - 0.039 14.6 0.3 0.042 14.5 0.3 1.1 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain FtsJ PF01728.19 KOO28040.1 - 2.8e-10 40.6 0.0 5.1e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Galactosyl_T PF01762.21 KOO28041.1 - 1.4e-08 34.8 0.0 0.0065 16.3 0.0 2.5 2 1 0 2 2 2 2 Galactosyltransferase Methyltransf_34 PF11312.8 KOO28043.1 - 0.0024 17.2 0.0 0.0033 16.7 0.0 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Amino_oxidase PF01593.24 KOO28044.1 - 1.4e-69 235.5 1.1 3.6e-68 230.9 1.1 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO28044.1 - 6.5e-08 32.7 0.0 1.7e-07 31.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOO28044.1 - 0.00011 22.3 0.1 0.00038 20.5 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 KOO28044.1 - 0.00048 19.8 0.9 0.00091 18.9 0.3 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 KOO28044.1 - 0.0022 17.3 0.2 0.004 16.4 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 KOO28044.1 - 0.0036 16.6 0.1 0.096 11.9 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOO28044.1 - 0.042 13.1 0.9 0.076 12.3 0.9 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MAD PF05557.13 KOO28045.1 - 0.00031 19.2 2.0 0.00039 18.9 2.0 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein CENP-Q PF13094.6 KOO28045.1 - 0.011 16.0 0.2 0.018 15.3 0.2 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit SMG1 PF15785.5 KOO28045.1 - 0.026 12.9 0.1 0.035 12.5 0.1 1.1 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 MAGSP PF03082.14 KOO28045.1 - 0.081 12.5 0.7 0.1 12.2 0.7 1.1 1 0 0 1 1 1 0 Male accessory gland secretory protein BRE1 PF08647.11 KOO28045.1 - 0.1 12.7 2.1 0.11 12.6 0.2 1.8 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase MbeD_MobD PF04899.12 KOO28045.1 - 0.21 11.7 2.6 1.3 9.2 0.8 2.3 1 1 0 2 2 2 0 MbeD/MobD like DUF1993 PF09351.10 KOO28046.1 - 0.094 12.9 1.7 6.4 6.9 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) DUF498 PF04430.14 KOO28046.1 - 0.35 11.0 3.3 5.3 7.2 2.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF498/DUF598) YabA PF06156.13 KOO28047.1 - 0.03 15.0 0.9 0.074 13.7 0.2 1.9 1 1 1 2 2 2 0 Initiation control protein YabA UVR PF02151.19 KOO28048.1 - 5.1e-13 48.3 8.0 1.6e-06 27.6 2.6 2.5 2 0 0 2 2 2 2 UvrB/uvrC motif DNA_pol_B PF00136.21 KOO28048.1 - 0.026 13.3 0.0 0.03 13.1 0.0 1.0 1 0 0 1 1 1 0 DNA polymerase family B YjhX_toxin PF09857.9 KOO28049.1 - 0.02 14.8 0.0 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 Putative toxin of bacterial toxin-antitoxin pair PMT PF02366.18 KOO28051.1 - 2.4e-36 125.6 0.0 3e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Pentapeptide_4 PF13599.6 KOO28052.1 - 4.7e-28 97.2 0.0 4.9e-07 29.8 0.1 8.4 5 2 5 10 10 10 7 Pentapeptide repeats (9 copies) EF-hand_1 PF00036.32 KOO28052.1 - 2.2e-06 26.8 0.5 1.5e-05 24.2 0.6 2.5 2 0 0 2 2 2 1 EF hand XK-related PF09815.9 KOO28052.1 - 9e-05 21.7 6.0 0.019 14.0 2.0 2.2 2 0 0 2 2 2 2 XK-related protein CPSase_L_D3 PF02787.19 KOO28052.1 - 0.00096 19.5 2.5 0.72 10.2 0.0 5.0 4 1 1 5 5 5 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain EF-hand_6 PF13405.6 KOO28052.1 - 0.0048 16.7 0.0 0.043 13.8 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO28052.1 - 0.025 14.1 4.2 0.055 13.0 0.6 3.5 3 0 0 3 3 3 0 EF hand EF-hand_8 PF13833.6 KOO28052.1 - 0.035 14.0 0.3 2.5 8.0 0.1 3.6 4 0 0 4 4 4 0 EF-hand domain pair AbiEi_4 PF13338.6 KOO28052.1 - 0.054 13.7 4.5 0.64 10.2 0.0 4.6 5 0 0 5 5 5 0 Transcriptional regulator, AbiEi antitoxin Ribosomal_L13e PF01294.18 KOO28052.1 - 0.078 12.8 23.3 1.6 8.6 0.2 10.6 5 3 4 12 12 12 0 Ribosomal protein L13e HTH_20 PF12840.7 KOO28052.1 - 0.1 12.6 4.8 3.7 7.7 0.1 6.1 6 0 0 6 6 6 0 Helix-turn-helix domain ABC_tran_CTD PF16326.5 KOO28052.1 - 0.51 10.6 4.0 2.3 8.5 4.0 2.3 1 0 0 1 1 1 0 ABC transporter C-terminal domain MFS_1 PF07690.16 KOO28053.1 - 2.8e-26 92.3 74.6 2.3e-24 86.0 44.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOO28053.1 - 0.52 9.1 13.5 0.11 11.3 1.7 2.9 2 1 0 3 3 3 0 MFS_1 like family MFS_2 PF13347.6 KOO28053.1 - 1 7.8 24.5 0.038 12.6 3.0 2.7 2 1 0 3 3 3 0 MFS/sugar transport protein TFIIA PF03153.13 KOO28053.1 - 1.9 8.4 6.2 2.4 8.1 6.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arm PF00514.23 KOO28054.1 - 3.6e-100 325.3 95.0 4.8e-07 29.6 0.2 29.4 28 1 2 30 30 30 21 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO28054.1 - 5.8e-17 61.5 5.3 0.044 13.8 0.0 9.5 8 2 2 10 10 10 6 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.20 KOO28054.1 - 3.5e-07 29.2 4.0 0.75 8.3 0.2 5.7 3 2 1 5 5 5 4 Adaptin N terminal region Arm_2 PF04826.13 KOO28054.1 - 2.6e-06 27.1 9.6 0.073 12.5 0.0 7.1 4 2 4 8 8 8 4 Armadillo-like V-ATPase_H_N PF03224.14 KOO28054.1 - 3.7e-06 26.4 2.4 0.36 10.1 0.0 5.2 4 3 0 4 4 4 2 V-ATPase subunit H DUF5578 PF17741.1 KOO28054.1 - 6.6e-06 25.7 10.3 3.5 7.0 0.1 6.3 4 2 2 6 6 6 4 Family of unknown function (DUF5578) V-ATPase_H_C PF11698.8 KOO28054.1 - 5.5e-05 23.3 3.9 1.1 9.3 0.0 5.7 5 1 0 6 6 6 2 V-ATPase subunit H DUF4062 PF13271.6 KOO28055.1 - 8.6e-11 42.1 0.1 4.1e-10 39.9 0.1 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) TPR_12 PF13424.6 KOO28055.1 - 4.8e-07 30.0 9.8 0.00032 20.9 0.2 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat NACHT PF05729.12 KOO28055.1 - 9.8e-07 28.8 0.9 1.3e-05 25.2 0.0 3.1 3 0 0 3 3 3 1 NACHT domain AAA_16 PF13191.6 KOO28055.1 - 0.00036 21.0 0.1 0.00036 21.0 0.1 4.1 4 1 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 KOO28055.1 - 0.012 15.9 0.0 0.12 12.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain TPR_7 PF13176.6 KOO28055.1 - 0.079 13.0 2.5 20 5.5 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat AhpC-TSA PF00578.21 KOO28056.1 - 5.8e-05 23.0 0.0 0.00011 22.1 0.0 1.6 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 KOO28056.1 - 0.00017 21.9 0.0 0.00025 21.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 KOO28056.1 - 0.003 17.3 0.0 0.0043 16.8 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin PF00085.20 KOO28056.1 - 0.087 12.8 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_2 PF13098.6 KOO28056.1 - 0.11 13.0 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain SCO1-SenC PF02630.14 KOO28056.1 - 0.12 12.2 0.0 0.34 10.8 0.0 1.6 1 1 0 1 1 1 0 SCO1/SenC LON_substr_bdg PF02190.16 KOO28057.1 - 1e-13 51.7 0.0 1.4e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain Thioesterase PF00975.20 KOO28057.1 - 5.6e-06 26.6 0.0 8.8e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain 2OG-FeII_Oxy_3 PF13640.6 KOO28058.1 - 2.6e-09 37.8 0.0 5.2e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 KOO28058.1 - 0.00023 20.8 0.0 0.0019 17.7 0.0 2.2 2 1 1 3 3 3 1 Oxygenase, catalysing oxidative methylation of damaged DNA 2OG-FeII_Oxy_5 PF13759.6 KOO28058.1 - 0.0021 18.5 0.0 0.012 16.0 0.0 2.2 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_2 PF13532.6 KOO28058.1 - 0.021 15.0 0.0 0.026 14.7 0.0 1.1 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 KOO28058.1 - 0.11 12.7 0.0 0.31 11.3 0.0 1.6 1 1 1 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) zf-CXXC PF02008.20 KOO28059.1 - 0.034 14.2 0.4 0.049 13.6 0.4 1.3 1 0 0 1 1 1 0 CXXC zinc finger domain Peptidase_C1 PF00112.23 KOO28060.1 - 1.6e-57 195.1 0.0 2.2e-57 194.7 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KOO28060.1 - 4.8e-06 26.9 0.0 7.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KOO28060.1 - 0.00014 20.8 1.8 0.023 13.5 0.7 2.2 2 0 0 2 2 2 2 Peptidase C1-like family DEAD PF00270.29 KOO28061.1 - 2.4e-17 63.2 0.0 5.9e-17 62.0 0.0 1.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO28061.1 - 2.3e-06 27.7 0.0 4.5e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOO28061.1 - 0.01 16.1 0.1 0.024 14.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain DNA_pol_A PF00476.20 KOO28062.1 - 5.6e-85 285.6 0.0 4e-72 243.3 0.0 3.1 3 0 0 3 3 3 3 DNA polymerase family A PEPcase PF00311.17 KOO28063.1 - 6.2e-236 785.3 0.0 7.3e-236 785.0 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 KOO28063.1 - 5.2e-07 28.5 0.0 8e-07 27.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase Methyltransf_24 PF13578.6 KOO28065.1 - 3.6e-05 24.7 0.0 6.5e-05 23.9 0.1 1.4 2 0 0 2 2 2 1 Methyltransferase domain MBOAT_2 PF13813.6 KOO28066.1 - 7.6e-11 42.1 1.8 1.6e-10 41.1 1.8 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family MBOAT PF03062.19 KOO28066.1 - 0.016 14.6 0.6 0.023 14.0 0.6 1.2 1 0 0 1 1 1 0 MBOAT, membrane-bound O-acyltransferase family YrzO PF14142.6 KOO28066.1 - 0.37 10.7 1.4 1.2 9.1 0.1 2.2 2 0 0 2 2 2 0 YrzO-like protein SspN PF08177.11 KOO28068.1 - 0.01 15.7 0.4 0.022 14.7 0.4 1.5 1 0 0 1 1 1 0 Small acid-soluble spore protein N family FliM PF02154.15 KOO28068.1 - 0.051 13.5 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Flagellar motor switch protein FliM Sec3_C_2 PF15278.6 KOO28068.1 - 6.7 7.1 6.3 1.3 9.4 0.6 2.8 2 1 1 3 3 3 0 Sec3 exocyst complex subunit Pkinase PF00069.25 KOO28070.1 - 2.6e-35 122.1 0.0 4.1e-35 121.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28070.1 - 6.5e-29 101.0 0.0 1.1e-28 100.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 KOO28070.1 - 1.3e-12 48.1 0.0 4.3e-06 27.2 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO28070.1 - 3e-10 40.1 0.2 6.9e-07 29.4 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO28070.1 - 5.2e-10 39.3 0.4 0.00011 22.4 0.1 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 KOO28070.1 - 8.8e-09 35.7 2.2 0.00076 20.0 0.0 4.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28070.1 - 1.7e-05 24.8 0.0 0.037 14.6 0.0 4.5 5 0 0 5 5 5 1 Ankyrin repeat ApbE PF02424.15 KOO28070.1 - 0.02 14.4 0.1 0.044 13.3 0.1 1.5 1 0 0 1 1 1 0 ApbE family Ank_4 PF13637.6 KOO28071.1 - 1.9e-14 53.8 0.4 3.8e-08 33.7 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO28071.1 - 1.6e-11 44.6 0.0 3.8e-11 43.4 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO28071.1 - 4.4e-11 42.8 0.4 2.6e-10 40.4 0.1 2.4 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28071.1 - 1.4e-08 34.3 0.0 2.6e-05 24.3 0.1 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 KOO28071.1 - 8.3e-06 26.0 0.1 0.00011 22.5 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeat TerC PF03741.16 KOO28072.1 - 5.3e-42 143.5 2.7 9.1e-42 142.8 2.7 1.3 1 0 0 1 1 1 1 Integral membrane protein TerC family EF-hand_8 PF13833.6 KOO28072.1 - 0.00075 19.3 0.0 0.0019 18.0 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO28072.1 - 0.01 15.7 0.0 0.03 14.3 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 KOO28072.1 - 0.083 12.5 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 EF hand Asp_protease_2 PF13650.6 KOO28073.1 - 0.0093 16.6 0.4 0.77 10.4 0.1 2.7 2 0 0 2 2 2 1 Aspartyl protease Kringle PF00051.18 KOO28073.1 - 0.18 12.2 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 Kringle domain gag-asp_proteas PF13975.6 KOO28073.1 - 0.2 12.3 0.6 8.5 7.0 0.0 2.9 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease Exostosin PF03016.15 KOO28074.1 - 1.3e-19 70.5 0.1 2.3e-19 69.7 0.1 1.3 1 1 0 1 1 1 1 Exostosin family EF-hand_6 PF13405.6 KOO28075.1 - 2e-60 195.6 28.3 2.1e-06 27.2 0.2 12.0 12 0 0 12 12 12 10 EF-hand domain EF-hand_1 PF00036.32 KOO28075.1 - 3e-57 186.0 27.3 1.4e-06 27.4 0.3 11.4 12 0 0 12 12 12 10 EF hand EF-hand_7 PF13499.6 KOO28075.1 - 4.4e-52 174.4 23.1 6.9e-11 42.4 1.6 6.6 5 1 1 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO28075.1 - 1.9e-43 144.1 37.8 8.9e-06 25.0 0.1 10.7 11 0 0 11 11 11 8 EF hand EF-hand_8 PF13833.6 KOO28075.1 - 2.5e-33 113.7 30.9 3.1e-06 26.9 0.9 10.4 6 5 5 11 11 11 10 EF-hand domain pair EF-hand_11 PF08976.11 KOO28075.1 - 2.5e-16 60.4 0.1 0.014 16.3 0.0 5.3 3 1 1 5 5 5 4 EF-hand domain EF-hand_9 PF14658.6 KOO28075.1 - 4.6e-11 42.9 1.1 0.0017 18.6 0.0 6.7 6 1 1 7 7 7 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO28075.1 - 2.3e-08 34.4 0.1 4.6 7.6 0.0 5.8 4 2 1 6 6 6 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO28075.1 - 0.00022 21.2 3.3 5 7.0 0.0 6.1 5 3 3 8 8 8 1 Caleosin related protein EF-hand_14 PF17959.1 KOO28075.1 - 0.001 19.4 2.2 3.8 7.9 0.0 5.3 7 2 1 8 8 7 1 EF-hand domain DinB_2 PF12867.7 KOO28075.1 - 0.0047 17.4 1.5 0.85 10.1 0.1 3.3 3 1 1 4 4 4 1 DinB superfamily Dockerin_1 PF00404.18 KOO28075.1 - 0.0074 16.5 1.1 2.2 8.6 0.0 4.2 4 0 0 4 4 4 1 Dockerin type I domain DNA_ligase_OB_2 PF14743.6 KOO28076.1 - 6e-27 93.5 0.4 1.1e-26 92.7 0.4 1.4 1 0 0 1 1 1 1 DNA ligase OB-like domain Menin PF05053.13 KOO28077.1 - 3.3 6.0 9.7 4.2 5.6 9.7 1.1 1 0 0 1 1 1 0 Menin Nop53 PF07767.11 KOO28077.1 - 7.8 5.8 19.6 11 5.3 19.6 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SH3_4 PF06347.13 KOO28081.1 - 2.7e-05 23.9 0.1 4.9e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_3 PF08239.11 KOO28081.1 - 0.0098 16.2 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain OTCace_N PF02729.21 KOO28082.1 - 2.5e-46 157.3 0.3 4.8e-46 156.4 0.1 1.6 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 KOO28082.1 - 3.6e-28 98.6 0.0 5.7e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain TPR_12 PF13424.6 KOO28083.1 - 2.9e-42 142.8 15.9 2.8e-15 56.3 1.3 3.8 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO28083.1 - 8.1e-39 130.4 9.1 2.2e-12 46.4 0.3 5.1 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28083.1 - 2.9e-14 51.9 6.4 0.00026 20.8 0.0 4.0 4 1 0 4 4 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28083.1 - 7.5e-12 44.5 2.7 0.006 16.4 0.0 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28083.1 - 8.1e-12 44.4 1.7 0.021 15.0 0.0 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28083.1 - 1.1e-09 37.7 3.1 0.039 14.1 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO28083.1 - 3.7e-09 36.4 0.8 0.00011 21.8 0.2 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_4 PF07721.14 KOO28083.1 - 9.8e-09 35.0 6.0 0.15 12.8 0.5 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28083.1 - 3e-08 33.8 7.5 0.12 13.3 0.0 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28083.1 - 3.5e-05 23.9 1.1 2.5 8.7 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28083.1 - 6.8e-05 23.4 16.7 0.12 13.1 0.0 4.1 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28083.1 - 0.00011 22.7 5.6 0.019 15.4 0.6 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO28083.1 - 0.0034 17.6 0.0 38 4.7 0.0 4.1 4 0 0 4 4 4 0 Osmosensory transporter coiled coil HisKA_3 PF07730.13 KOO28083.1 - 0.0058 17.1 2.1 11 6.6 0.0 3.5 1 1 2 3 3 3 0 Histidine kinase Hairpins PF04877.12 KOO28083.1 - 0.0096 15.6 0.1 1.4 8.5 0.1 2.8 1 1 0 1 1 1 1 HrpZ TPR_3 PF07720.12 KOO28083.1 - 0.012 15.5 0.0 14 5.8 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4404 PF14357.6 KOO28083.1 - 0.1 13.2 0.2 15 6.3 0.0 3.1 1 1 1 3 3 3 0 Domain of unknown function (DUF4404) LIP1 PF15904.5 KOO28083.1 - 0.39 11.1 2.4 36 4.8 0.1 3.4 3 1 0 3 3 3 0 LKB1 serine/threonine kinase interacting protein 1 Ank_2 PF12796.7 KOO28086.1 - 1e-21 77.3 8.3 4.1e-09 36.9 1.0 3.2 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO28086.1 - 1e-13 50.1 0.8 0.0012 19.1 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KOO28086.1 - 1.2e-13 50.9 2.9 1.1e-05 25.6 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO28086.1 - 7.9e-11 42.3 2.2 1.5e-06 28.6 0.2 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO28086.1 - 1e-10 41.5 4.9 0.00033 21.0 0.3 3.7 3 0 0 3 3 3 3 Ankyrin repeat Cytochrom_B561 PF03188.16 KOO28088.1 - 2.7e-16 60.0 13.8 2.7e-16 60.0 13.8 2.0 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 60KD_IMP PF02096.20 KOO28088.1 - 0.013 15.4 3.5 0.24 11.3 0.1 2.5 2 1 0 3 3 3 0 60Kd inner membrane protein DUF3382 PF11862.8 KOO28088.1 - 2.7 8.3 12.8 0.88 9.9 0.2 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF3382) DUF2427 PF10348.9 KOO28088.1 - 7.3 6.4 17.7 8.2 6.3 8.6 4.0 3 1 2 5 5 5 0 Domain of unknown function (DUF2427) FYVE PF01363.21 KOO28089.1 - 4.2e-18 65.3 10.5 8.2e-18 64.3 10.5 1.5 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 KOO28089.1 - 0.00039 20.6 4.2 0.00077 19.7 4.2 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger Prok-RING_2 PF14445.6 KOO28089.1 - 0.52 10.5 4.7 1.5 9.1 4.7 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 RRM_1 PF00076.22 KOO28090.1 - 2.7e-60 200.1 0.0 1e-19 70.1 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOO28090.1 - 1.9e-09 37.5 0.1 0.013 15.6 0.0 3.4 3 1 0 3 3 3 3 RNA recognition motif DUF3343 PF11823.8 KOO28090.1 - 7.2e-06 25.4 0.0 1.9 8.0 0.0 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF3343) RRM_occluded PF16842.5 KOO28090.1 - 2.5e-05 24.1 0.0 4.6 7.2 0.0 3.3 3 0 0 3 3 3 3 Occluded RNA-recognition motif RRM_3 PF08777.11 KOO28090.1 - 9.9e-05 22.3 0.0 3.5 7.7 0.0 3.3 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.6 KOO28090.1 - 0.01 15.8 0.0 7.3 6.7 0.0 2.6 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 KOO28090.1 - 0.013 15.1 0.0 23 4.6 0.0 3.2 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_racemase PF05544.11 KOO28090.1 - 0.014 14.4 0.0 0.051 12.6 0.0 1.8 3 0 0 3 3 3 0 Proline racemase DUF2141 PF09912.9 KOO28090.1 - 0.17 11.8 0.0 29 4.6 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2141) GDP_Man_Dehyd PF16363.5 KOO28090.1 - 0.3 10.4 0.9 21 4.4 0.0 2.4 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase VWA_2 PF13519.6 KOO28091.1 - 3.7e-06 27.6 0.1 2e-05 25.2 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 KOO28091.1 - 0.00082 19.7 0.0 0.0022 18.3 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain HalX PF08663.10 KOO28091.1 - 0.053 13.9 0.9 0.2 12.0 0.0 2.1 2 0 0 2 2 2 0 HalX domain Peptidase_S8 PF00082.22 KOO28092.1 - 4.3e-18 65.6 1.5 8.1e-18 64.7 1.5 1.5 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KOO28092.1 - 8.4e-08 32.1 0.1 1.7e-06 28.0 0.0 2.8 3 0 0 3 3 3 1 Proprotein convertase P-domain PDZ_2 PF13180.6 KOO28092.1 - 0.023 15.0 0.1 0.059 13.7 0.0 1.7 2 0 0 2 2 2 0 PDZ domain CwsA PF10814.8 KOO28092.1 - 0.056 13.6 2.1 0.17 12.1 2.1 1.8 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA HA2 PF04408.23 KOO28092.1 - 0.15 12.4 1.3 2.2 8.6 1.0 2.3 2 0 0 2 2 2 0 Helicase associated domain (HA2) Phospholip_B PF04916.13 KOO28093.1 - 1.5e-119 400.0 0.0 2.4e-97 326.8 0.0 2.9 2 1 0 2 2 2 2 Phospholipase B DUF3456 PF11938.8 KOO28094.1 - 0.00058 20.4 0.5 0.012 16.1 0.1 2.1 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP Alpha_kinase PF02816.18 KOO28095.1 - 1.1e-34 120.1 0.0 1.5e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family Flavodoxin_1 PF00258.25 KOO28098.1 - 1.3e-07 31.9 0.0 2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin SET PF00856.28 KOO28099.1 - 2e-05 25.0 0.0 6e-05 23.5 0.0 2.0 1 1 0 1 1 1 1 SET domain PARP PF00644.20 KOO28100.1 - 7.7e-19 68.1 0.0 1.5e-18 67.1 0.0 1.4 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UBA PF00627.31 KOO28100.1 - 1e-07 31.7 0.2 3.2e-07 30.1 0.3 1.8 2 0 0 2 2 2 1 UBA/TS-N domain HOIP-UBA PF16678.5 KOO28100.1 - 0.00013 22.0 0.1 0.00021 21.3 0.1 1.3 1 0 0 1 1 1 1 HOIP UBA domain pair UBA_4 PF14555.6 KOO28100.1 - 0.0011 18.8 0.3 0.0018 18.1 0.3 1.3 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.16 KOO28100.1 - 0.0026 17.4 0.1 0.0045 16.7 0.1 1.4 1 0 0 1 1 1 1 CUE domain NYN_YacP PF05991.11 KOO28101.1 - 0.0042 17.1 0.4 0.016 15.1 0.0 1.9 2 0 0 2 2 2 1 YacP-like NYN domain HMG-CoA_red PF00368.18 KOO28101.1 - 0.096 11.7 0.1 0.14 11.2 0.1 1.2 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A reductase Thioredoxin PF00085.20 KOO28102.1 - 2.7e-25 88.3 0.1 4.7e-25 87.6 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin UBA PF00627.31 KOO28102.1 - 3.6e-07 29.9 0.6 7.6e-07 28.9 0.6 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Thioredoxin_9 PF14595.6 KOO28102.1 - 6.9e-06 25.9 0.0 9.7e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KOO28102.1 - 2.2e-05 24.0 0.1 2.7e-05 23.7 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KOO28102.1 - 4.9e-05 23.7 0.8 0.0013 19.2 0.8 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KOO28102.1 - 0.00025 21.2 0.1 0.00057 20.0 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.6 KOO28102.1 - 0.00029 21.1 0.0 0.00044 20.5 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like HOIP-UBA PF16678.5 KOO28102.1 - 0.00053 20.0 0.3 0.0018 18.3 0.4 1.8 1 1 0 1 1 1 1 HOIP UBA domain pair Redoxin PF08534.10 KOO28102.1 - 0.013 15.2 0.5 1.2 8.9 0.1 2.3 1 1 1 2 2 2 0 Redoxin AhpC-TSA PF00578.21 KOO28102.1 - 0.015 15.2 0.2 0.05 13.5 0.2 1.8 1 1 0 1 1 1 0 AhpC/TSA family CUE PF02845.16 KOO28102.1 - 0.019 14.7 0.1 0.038 13.7 0.1 1.5 1 0 0 1 1 1 0 CUE domain Glutaredoxin PF00462.24 KOO28102.1 - 0.03 14.5 0.0 0.07 13.4 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin Lipase_3 PF01764.25 KOO28102.1 - 0.043 13.7 0.1 0.058 13.3 0.1 1.3 1 0 0 1 1 1 0 Lipase (class 3) UBA_4 PF14555.6 KOO28102.1 - 0.05 13.4 1.8 0.056 13.3 0.4 1.8 2 0 0 2 2 2 0 UBA-like domain Lipase_3 PF01764.25 KOO28103.1 - 2.1e-20 73.0 0.0 3.7e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) FYVE PF01363.21 KOO28103.1 - 6.4e-06 26.2 4.8 1.5e-05 25.0 4.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger Pkinase PF00069.25 KOO28106.1 - 1.2e-17 64.2 0.0 2.3e-17 63.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain PP2C PF00481.21 KOO28106.1 - 2.6e-11 43.7 0.0 1.7e-10 40.9 0.0 2.0 1 1 1 2 2 2 1 Protein phosphatase 2C Pkinase_Tyr PF07714.17 KOO28106.1 - 0.00021 20.7 0.0 0.00095 18.5 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase PDZ_6 PF17820.1 KOO28106.1 - 0.00033 20.4 0.1 0.0014 18.5 0.1 2.1 2 0 0 2 2 2 1 PDZ domain APH PF01636.23 KOO28106.1 - 0.0016 18.4 0.1 0.0038 17.2 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family PDZ PF00595.24 KOO28106.1 - 0.04 14.3 0.0 0.086 13.2 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Kdo PF06293.14 KOO28106.1 - 0.11 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO28106.1 - 0.25 10.1 0.0 0.38 9.5 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 KOO28106.1 - 0.28 10.8 0.0 0.43 10.2 0.0 1.2 1 0 0 1 1 1 0 RIO1 family ArfGap PF01412.18 KOO28107.1 - 1.4e-25 89.7 0.8 1.6e-25 89.5 0.8 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GRDA PF04723.14 KOO28107.1 - 0.064 13.0 0.1 0.083 12.7 0.1 1.2 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A HscB_4_cys PF18256.1 KOO28109.1 - 0.087 12.7 0.7 0.16 11.8 0.7 1.5 1 0 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif TSNAXIP1_N PF15739.5 KOO28110.1 - 1.6e-08 34.9 0.2 3.6e-08 33.8 0.2 1.6 1 0 0 1 1 1 1 Translin-associated factor X-interacting N-terminus EF-hand_7 PF13499.6 KOO28110.1 - 0.00057 20.3 0.1 0.0041 17.6 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO28110.1 - 0.0026 17.2 0.0 0.0064 16.0 0.0 1.7 1 0 0 1 1 1 1 EF hand DUF4407 PF14362.6 KOO28110.1 - 0.0028 17.0 0.2 0.007 15.8 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) EF-hand_6 PF13405.6 KOO28110.1 - 0.0088 15.9 0.1 0.077 13.0 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain DivIC PF04977.15 KOO28110.1 - 0.012 15.4 3.6 0.015 15.1 1.0 2.5 2 0 0 2 2 2 0 Septum formation initiator EF-hand_8 PF13833.6 KOO28110.1 - 0.013 15.3 0.0 0.027 14.3 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair TPR_MLP1_2 PF07926.12 KOO28110.1 - 0.013 15.5 2.0 0.048 13.7 2.0 1.9 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein EF-hand_5 PF13202.6 KOO28110.1 - 0.014 14.9 0.3 0.033 13.7 0.3 1.7 1 0 0 1 1 1 0 EF hand Spc7 PF08317.11 KOO28110.1 - 0.03 13.2 0.7 0.055 12.3 0.7 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Filament PF00038.21 KOO28110.1 - 0.04 13.5 0.2 0.076 12.6 0.2 1.5 1 0 0 1 1 1 0 Intermediate filament protein THOC7 PF05615.13 KOO28110.1 - 0.081 13.2 1.1 0.29 11.4 1.1 1.9 1 0 0 1 1 1 0 Tho complex subunit 7 SlyX PF04102.12 KOO28110.1 - 0.39 11.4 2.3 2.2 9.0 0.7 2.9 1 1 1 2 2 2 0 SlyX FAM184 PF15665.5 KOO28110.1 - 2.5 7.8 5.1 0.36 10.6 0.6 1.8 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B adh_short PF00106.25 KOO28111.1 - 2e-17 63.3 0.3 5.9e-15 55.2 0.1 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO28111.1 - 1.5e-08 34.5 1.1 7.2e-08 32.3 0.2 2.3 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO28111.1 - 1.1e-07 32.0 1.0 8.6e-07 29.0 0.4 2.2 1 1 0 2 2 2 1 KR domain Epimerase PF01370.21 KOO28111.1 - 0.11 11.9 0.1 0.19 11.2 0.1 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DAGAT PF03982.13 KOO28112.1 - 2.6e-40 138.2 0.0 3.3e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase TPR_1 PF00515.28 KOO28113.1 - 5.4e-33 111.5 4.2 3.8e-06 26.5 0.0 8.8 10 0 0 10 10 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28113.1 - 1.3e-29 99.9 18.7 1.4e-05 24.8 0.0 10.1 12 0 0 12 12 10 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28113.1 - 3.3e-29 98.6 2.4 1.9e-05 24.5 0.0 9.2 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28113.1 - 5.1e-18 64.5 0.3 3.9e-06 26.4 0.0 6.8 4 2 4 8 8 8 4 TPR repeat TPR_16 PF13432.6 KOO28113.1 - 6.5e-17 61.9 20.7 2.4e-05 24.9 0.0 7.1 6 1 2 8 8 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28113.1 - 6.4e-16 57.1 9.2 0.0011 18.8 0.0 6.8 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28113.1 - 2.1e-15 56.1 23.5 0.022 15.6 0.0 10.6 6 3 5 11 11 11 4 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO28113.1 - 7.2e-15 55.0 22.5 3.5e-14 52.8 3.2 6.1 5 1 1 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KOO28113.1 - 2e-14 53.6 9.2 9.3e-06 25.8 0.1 7.9 7 3 2 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28113.1 - 1.7e-12 47.6 4.2 0.14 12.6 0.0 6.4 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28113.1 - 1.8e-11 43.6 0.0 0.048 14.1 0.0 6.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_3 PF07720.12 KOO28113.1 - 2.8e-09 36.8 0.2 0.0016 18.4 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO28113.1 - 1.3e-08 34.4 12.6 0.0058 16.5 0.0 6.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28113.1 - 1.6e-07 31.4 6.7 0.038 14.2 0.2 5.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 KOO28113.1 - 2.1e-06 28.0 11.1 2.5 8.9 0.0 8.9 9 1 0 9 9 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO28113.1 - 0.0012 18.1 6.7 0.63 9.2 0.1 4.7 2 2 3 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO28113.1 - 0.0019 18.7 3.5 20 6.2 0.0 5.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO28113.1 - 0.019 15.0 1.2 1.1 9.4 0.0 3.6 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat SIX1_SD PF16878.5 KOO28113.1 - 0.067 13.7 3.0 1.5 9.4 0.5 3.3 4 0 0 4 4 3 0 Transcriptional regulator, SIX1, N-terminal SD domain ANAPC8 PF04049.13 KOO28113.1 - 0.12 12.5 3.1 0.06 13.4 0.6 1.8 2 0 0 2 2 2 0 Anaphase promoting complex subunit 8 / Cdc23 DUF4838 PF16126.5 KOO28114.1 - 1.1e-57 195.4 0.1 1.8e-28 99.6 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4838) Glyco_hydro_67N PF03648.14 KOO28114.1 - 0.00069 19.9 0.0 0.0017 18.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus TPR_1 PF00515.28 KOO28115.1 - 4.4e-07 29.4 9.4 6e-05 22.7 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28115.1 - 8.5e-07 28.6 14.9 0.0005 20.0 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28115.1 - 0.0001 22.8 0.8 0.0001 22.8 0.8 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28115.1 - 0.00074 20.1 13.9 0.0043 17.7 1.7 5.5 4 2 1 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28115.1 - 0.0056 17.4 2.0 0.0056 17.4 2.0 5.0 5 1 1 6 6 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28115.1 - 0.0075 16.6 0.3 3.6 8.2 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28115.1 - 0.011 15.4 3.1 0.13 11.9 0.1 3.3 3 0 0 3 3 3 0 TPR repeat TPR_7 PF13176.6 KOO28115.1 - 0.017 15.1 4.5 0.061 13.4 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28115.1 - 0.027 14.7 6.9 0.19 12.0 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28115.1 - 0.039 14.2 15.9 0.14 12.4 1.9 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 KOO28115.1 - 0.29 11.6 10.1 0.17 12.4 5.0 2.9 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 KOO28115.1 - 4.8 7.2 8.5 3.1 7.8 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat CSD PF00313.22 KOO28118.1 - 1.3e-21 76.2 0.0 1.7e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KOO28118.1 - 0.0011 18.6 0.1 0.0025 17.5 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain Aldose_epim PF01263.20 KOO28119.1 - 3.2e-43 148.2 0.0 3.6e-43 148.0 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase MutS_I PF01624.20 KOO28120.1 - 1.6e-20 73.5 0.0 3.3e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 MutS domain I Ion_trans PF00520.31 KOO28120.1 - 2.3e-14 53.2 0.4 3.5e-14 52.6 0.4 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO28120.1 - 1.7e-13 50.3 7.2 4.8e-13 48.9 7.2 1.8 1 1 0 1 1 1 1 Ion channel IRK PF01007.20 KOO28120.1 - 0.016 15.1 0.8 0.028 14.3 0.8 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain AKAP28 PF14469.6 KOO28120.1 - 0.12 12.1 1.5 0.2 11.4 0.4 1.8 2 0 0 2 2 2 0 28 kDa A-kinase anchor GYF_2 PF14237.6 KOO28121.1 - 1.1e-06 28.4 0.0 2.2e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 GYF domain 2 Ribosomal_S18 PF01084.20 KOO28121.1 - 0.4 10.9 2.3 0.44 10.8 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein S18 Methyltransf_25 PF13649.6 KOO28122.1 - 9.9e-10 39.0 0.1 1.3e-09 38.7 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO28122.1 - 3.7e-08 33.9 0.1 5.2e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO28122.1 - 4.5e-06 26.2 0.0 5e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 KOO28122.1 - 4.7e-06 26.5 0.0 5.6e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO28122.1 - 6.5e-06 26.8 0.0 8.5e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO28122.1 - 0.00053 19.9 0.0 0.00065 19.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Flavokinase PF01687.17 KOO28126.1 - 5e-31 107.3 0.0 9.2e-31 106.4 0.0 1.4 2 0 0 2 2 2 1 Riboflavin kinase Dpy-30 PF05186.13 KOO28126.1 - 0.013 15.2 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Dpy-30 motif DS PF01916.17 KOO28127.1 - 1.3e-124 415.1 0.0 1.5e-124 414.9 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase DUF751 PF05421.11 KOO28128.1 - 6.7e-12 46.0 4.2 1.4e-11 44.9 4.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF751) V4R PF02830.18 KOO28128.1 - 0.0091 16.0 0.3 0.03 14.3 0.0 1.9 2 0 0 2 2 2 1 V4R domain DUF4131 PF13567.6 KOO28128.1 - 0.057 13.1 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Kinesin PF00225.23 KOO28131.1 - 1.7e-54 185.0 0.0 2.5e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Ank_2 PF12796.7 KOO28131.1 - 1.3e-15 57.7 0.0 5e-15 55.9 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO28131.1 - 1.7e-14 54.0 0.0 2.1e-06 28.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO28131.1 - 7.3e-12 45.3 0.0 5.9e-07 29.7 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO28131.1 - 2.6e-11 43.4 0.0 0.00011 22.5 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Microtub_bd PF16796.5 KOO28131.1 - 1.8e-10 41.0 0.0 3.7e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Ank_3 PF13606.6 KOO28131.1 - 1.1e-07 31.6 0.0 0.025 15.1 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat 2OG-FeII_Oxy_5 PF13759.6 KOO28131.1 - 3.1e-07 30.8 0.2 1.6e-06 28.4 0.2 2.2 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase EF-hand_6 PF13405.6 KOO28131.1 - 0.0036 17.1 1.5 0.09 12.8 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 KOO28131.1 - 0.006 17.0 1.1 0.017 15.6 1.1 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO28131.1 - 0.0062 16.0 0.0 0.0062 16.0 0.0 3.1 5 0 0 5 5 5 1 EF hand EF-hand_1 PF00036.32 KOO28131.1 - 0.01 15.3 1.5 0.059 12.9 0.0 2.9 3 0 0 3 3 3 0 EF hand AAA_30 PF13604.6 KOO28131.1 - 0.21 11.3 1.0 0.39 10.4 0.1 1.9 2 0 0 2 2 2 0 AAA domain SPEG_u2 PF16650.5 KOO28131.1 - 6.9 6.9 6.2 1.8 8.8 2.1 2.3 2 0 0 2 2 2 0 Unstructured region on SPEG complex protein HisKA PF00512.25 KOO28133.1 - 0.043 13.8 0.3 0.043 13.8 0.3 1.9 2 1 0 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF896 PF05979.12 KOO28133.1 - 0.052 13.4 0.3 0.052 13.4 0.3 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF896) CCDC-167 PF15188.6 KOO28133.1 - 0.64 10.4 12.3 1.4 9.3 4.5 2.7 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 PCEMA1 PF07418.11 KOO28133.1 - 1.5 8.3 6.5 1.7 8.1 6.5 1.0 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 GvpG PF05120.12 KOO28133.1 - 4.1 7.5 8.6 1.9 8.5 0.9 2.8 2 2 1 3 3 3 0 Gas vesicle protein G TetR_C_21 PF17926.1 KOO28133.1 - 9.7 6.4 11.6 0.73 10.0 1.4 2.6 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Aldo_ket_red PF00248.21 KOO28134.1 - 5e-24 85.0 0.0 6.7e-18 64.9 0.0 2.4 1 1 1 2 2 2 2 Aldo/keto reductase family Glyco_transf_8 PF01501.20 KOO28134.1 - 1.2e-07 31.6 0.0 1.2e-06 28.3 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 8 DUF4936 PF16290.5 KOO28134.1 - 0.088 13.5 0.2 3.4 8.4 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4936) PARP PF00644.20 KOO28135.1 - 1e-13 51.4 0.0 4e-13 49.4 0.0 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain 3HCDH_N PF02737.18 KOO28135.1 - 0.019 14.9 4.8 0.021 14.7 0.0 2.8 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Exonuc_VII_L PF02601.15 KOO28135.1 - 8 5.9 12.1 13 5.2 12.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4586 PF15239.6 KOO28136.1 - 2.1e-05 24.9 0.9 3.1e-05 24.3 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4586) Nucleotid_trans PF03407.16 KOO28137.1 - 0.053 13.5 0.0 0.077 13.0 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Herpes_UL47 PF03362.13 KOO28137.1 - 0.2 10.4 1.1 0.26 10.0 1.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL47 protein Radial_spoke PF04712.12 KOO28139.1 - 7.4e-10 38.4 0.2 0.00066 18.8 0.0 3.0 2 1 1 3 3 3 3 Radial spokehead-like protein CoA_transf_3 PF02515.17 KOO28141.1 - 2.2e-43 148.8 3.7 7.1e-36 124.1 0.1 3.1 2 1 0 2 2 2 2 CoA-transferase family III Anoctamin PF04547.12 KOO28142.1 - 3.6e-102 342.5 0.0 5.6e-102 341.9 0.0 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KOO28142.1 - 6.6e-09 35.8 0.2 1.5e-08 34.7 0.2 1.6 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin CCDC53 PF10152.9 KOO28142.1 - 2.9 8.3 6.8 8.3 6.8 6.8 1.8 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex PsbP PF01789.16 KOO28143.1 - 8.8e-07 29.2 0.0 1.2e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 PsbP zf-RING_2 PF13639.6 KOO28144.1 - 0.031 14.6 16.0 0.031 14.6 16.0 2.4 2 1 0 2 2 2 0 Ring finger domain C1_1 PF00130.22 KOO28144.1 - 0.19 11.6 11.5 0.54 10.2 11.5 1.8 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HWE_HK PF07536.14 KOO28144.1 - 0.2 12.4 0.7 8.8 7.1 0.0 2.5 2 0 0 2 2 2 0 HWE histidine kinase zf-RING_11 PF17123.5 KOO28144.1 - 2.8 7.8 7.5 9.7 6.0 7.5 2.0 1 0 0 1 1 1 0 RING-like zinc finger Laminin_G_3 PF13385.6 KOO28145.1 - 1.5e-10 41.4 0.0 1.7e-10 41.2 0.0 1.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.17 KOO28145.1 - 0.14 11.8 0.0 0.16 11.7 0.0 1.3 1 1 0 1 1 1 0 Pentaxin family NAD_binding_8 PF13450.6 KOO28146.1 - 9.4e-15 54.6 0.5 2.4e-14 53.3 0.5 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KOO28146.1 - 1e-09 38.2 0.0 5.2e-09 35.9 0.0 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase DAO PF01266.24 KOO28146.1 - 3.2e-09 36.9 0.2 2.5e-08 33.9 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOO28146.1 - 3.5e-06 26.4 0.1 6.2e-06 25.6 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 KOO28146.1 - 7.6e-06 25.3 0.5 1.2e-05 24.7 0.5 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 KOO28146.1 - 1.1e-05 24.8 0.1 2e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO28146.1 - 1.7e-05 25.3 0.3 3.8e-05 24.2 0.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KOO28146.1 - 2.6e-05 23.8 0.7 3.7e-05 23.3 0.7 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 KOO28146.1 - 2.7e-05 23.6 0.5 3.7e-05 23.1 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 KOO28146.1 - 0.0022 16.8 0.1 0.0074 15.0 0.5 1.6 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 KOO28146.1 - 0.0038 16.4 1.2 0.0055 15.8 1.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 KOO28146.1 - 0.023 14.0 0.5 0.039 13.2 0.5 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 KOO28146.1 - 0.053 13.4 0.6 0.085 12.7 0.6 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 KOO28146.1 - 0.053 12.6 0.3 0.12 11.4 0.3 1.6 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.14 KOO28146.1 - 0.12 11.2 0.7 0.17 10.7 0.7 1.2 1 0 0 1 1 1 0 Tryptophan halogenase MCRA PF06100.11 KOO28146.1 - 0.28 9.9 0.1 0.36 9.6 0.1 1.1 1 0 0 1 1 1 0 MCRA family EF-hand_6 PF13405.6 KOO28148.1 - 0.0055 16.5 0.1 0.013 15.4 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain TssO PF17561.2 KOO28148.1 - 0.025 14.7 1.1 0.044 13.9 1.1 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO COX16 PF14138.6 KOO28148.1 - 0.052 14.1 0.2 0.13 12.8 0.2 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 EF-hand_1 PF00036.32 KOO28148.1 - 0.076 12.6 0.3 0.17 11.5 0.3 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO28148.1 - 0.083 13.4 0.5 0.25 11.8 0.2 1.8 1 1 1 2 2 2 0 EF-hand domain pair SMC_N PF02463.19 KOO28150.1 - 9.6e-17 61.1 0.0 1.2e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOO28150.1 - 8.4e-12 46.0 0.0 8.5e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 KOO28150.1 - 9.3e-07 28.9 0.0 1.2e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOO28150.1 - 4.8e-06 26.2 0.0 9.1e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 KOO28150.1 - 6.8e-05 22.7 0.0 7.9e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_27 PF13514.6 KOO28150.1 - 0.0045 16.6 0.1 0.013 15.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 KOO28150.1 - 0.0049 16.3 0.0 0.0084 15.5 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family MukB PF04310.12 KOO28150.1 - 0.028 14.2 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 MukB N-terminal AP2 PF00847.20 KOO28151.1 - 4.7e-08 33.1 7.7 0.054 13.7 0.1 5.5 5 0 0 5 5 5 4 AP2 domain zf-RING_2 PF13639.6 KOO28152.1 - 2e-07 31.2 7.5 6.6e-07 29.6 7.5 1.9 1 1 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 KOO28152.1 - 3e-05 24.1 4.3 5.2e-05 23.3 4.3 1.4 1 1 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 KOO28152.1 - 0.00027 21.2 7.0 0.00063 20.0 7.0 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KOO28152.1 - 0.0013 18.6 6.3 0.0023 17.8 6.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO28152.1 - 0.0024 17.8 2.4 0.021 14.8 0.3 2.9 2 1 0 2 2 2 1 RING-type zinc-finger RINGv PF12906.7 KOO28152.1 - 0.02 15.0 5.4 0.046 13.9 5.4 1.7 1 1 0 1 1 1 0 RING-variant domain zf-C3HC4 PF00097.25 KOO28152.1 - 0.034 14.0 5.6 0.28 11.1 5.6 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO28152.1 - 0.041 13.7 10.0 0.48 10.3 3.6 3.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KOO28152.1 - 0.06 13.4 5.6 0.57 10.3 5.6 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger GETHR PF05671.11 KOO28152.1 - 0.11 11.9 0.6 0.19 11.1 0.6 1.3 1 0 0 1 1 1 0 GETHR pentapeptide repeat (5 copies) zf-RING_11 PF17123.5 KOO28152.1 - 0.34 10.7 4.8 4.4 7.1 4.8 2.3 1 1 0 1 1 1 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 KOO28152.1 - 0.46 10.4 12.0 10 6.1 12.0 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DNMT1-RFD PF12047.8 KOO28154.1 - 4.4e-18 65.7 0.0 9.1e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain HMG_box PF00505.19 KOO28154.1 - 2.9e-10 40.4 0.1 1.1e-09 38.5 0.1 2.0 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO28154.1 - 1.9e-08 34.8 1.4 2e-08 34.7 0.0 1.8 2 0 0 2 2 2 1 HMG-box domain ADH_N PF08240.12 KOO28155.1 - 1.1e-14 54.3 3.3 1.9e-14 53.5 3.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOO28155.1 - 3.2e-07 30.4 0.0 1.5e-06 28.2 0.0 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOO28155.1 - 0.00045 21.3 0.1 0.003 18.6 0.0 2.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Shikimate_DH PF01488.20 KOO28155.1 - 0.0043 17.1 0.0 0.0072 16.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 KOO28155.1 - 0.021 15.1 0.1 0.058 13.7 0.1 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Hydrolase PF00702.26 KOO28155.1 - 0.1 12.8 0.3 0.35 11.1 0.1 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Importin_rep_4 PF18808.1 KOO28158.1 - 3e-11 43.4 0.0 3e-11 43.4 0.0 3.7 4 0 0 4 4 4 1 Importin repeat MMS19_C PF12460.8 KOO28158.1 - 4e-06 26.2 0.8 0.27 10.3 0.0 4.3 5 0 0 5 5 5 2 RNAPII transcription regulator C-terminal Cnd3 PF12719.7 KOO28158.1 - 0.00057 19.2 0.2 0.0032 16.7 0.0 2.2 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 KOO28158.1 - 0.0036 17.8 5.9 0.014 15.9 0.6 12.8 11 3 3 15 15 15 3 HEAT-like repeat NopRA1 PF16201.5 KOO28158.1 - 0.0084 15.7 0.7 1.1 8.8 0.1 2.7 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 DUF4042 PF13251.6 KOO28158.1 - 0.0097 15.6 0.2 0.54 9.9 0.0 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4042) HEAT PF02985.22 KOO28158.1 - 0.061 13.6 30.0 0.4 11.1 0.1 10.5 12 0 0 12 12 12 0 HEAT repeat HEAT_2 PF13646.6 KOO28158.1 - 0.07 13.5 0.2 0.07 13.5 0.2 8.8 4 4 6 10 10 10 0 HEAT repeats RICTOR_V PF14668.6 KOO28158.1 - 0.12 12.6 0.0 0.33 11.2 0.0 1.8 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 cNMP_binding PF00027.29 KOO28159.1 - 4.1e-09 36.4 0.1 6.8e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain cNMP_binding PF00027.29 KOO28160.1 - 5e-25 87.4 0.1 1.2e-14 54.1 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DUF2486 PF10667.9 KOO28161.1 - 0.036 14.3 9.6 0.037 14.2 9.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) IHABP4_N PF16174.5 KOO28161.1 - 8.3 7.0 12.0 14 6.2 12.0 1.5 1 1 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal WD40 PF00400.32 KOO28163.1 - 3.5e-41 138.4 11.6 3.7e-09 37.1 0.2 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO28163.1 - 1.3e-14 53.9 0.7 0.01 14.8 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO28163.1 - 1.3e-14 54.2 0.5 0.031 14.5 0.0 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO28163.1 - 1.5e-11 43.9 0.3 0.26 11.3 0.0 4.4 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO28163.1 - 3.7e-07 28.8 0.0 0.011 14.0 0.0 2.8 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KOO28163.1 - 1.2e-06 28.6 0.1 0.0034 17.3 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 KOO28163.1 - 5.6e-06 26.4 0.2 1.1 9.4 0.0 3.8 1 1 3 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 KOO28163.1 - 1.1e-05 25.0 1.6 0.12 11.6 0.1 3.7 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DCX PF03607.17 KOO28163.1 - 1.8e-05 24.7 0.0 1.8 8.7 0.0 4.2 4 0 0 4 4 4 1 Doublecortin WD40_like PF17005.5 KOO28163.1 - 0.00031 20.2 0.1 0.0045 16.4 0.1 2.0 1 1 1 2 2 2 1 WD40-like domain DUF1513 PF07433.11 KOO28163.1 - 0.0024 17.0 0.0 3.9 6.4 0.0 3.2 1 1 3 4 4 4 1 Protein of unknown function (DUF1513) P22_Tail-4 PF11650.8 KOO28163.1 - 0.0048 16.9 0.0 0.4 10.6 0.0 2.8 1 1 2 3 3 3 1 P22 tail accessory factor rOmpB PF12334.8 KOO28163.1 - 0.015 14.8 1.2 15 5.0 0.0 3.7 1 1 2 4 4 4 0 Rickettsia outer membrane protein B Dfp1_Him1_M PF08630.10 KOO28163.1 - 0.019 15.2 4.6 18 5.5 0.0 4.0 4 0 0 4 4 4 0 Dfp1/Him1, central region Proteasome_A_N PF10584.9 KOO28163.1 - 0.17 11.6 5.7 87 2.9 0.1 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature TPT PF03151.16 KOO28164.1 - 7.4e-08 32.1 15.8 9e-08 31.8 15.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO28164.1 - 7.7e-07 29.4 27.5 1.1e-05 25.6 10.7 2.8 3 0 0 3 3 3 2 EamA-like transporter family Insulin_TMD PF17870.1 KOO28164.1 - 0.18 11.9 0.0 0.18 11.9 0.0 3.2 4 0 0 4 4 4 0 Insulin receptor trans-membrane segment DUF3357 PF11837.8 KOO28164.1 - 0.21 12.1 1.6 0.76 10.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) FixQ PF05545.11 KOO28164.1 - 0.22 11.5 4.3 24 5.0 0.3 3.9 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ DUF4079 PF13301.6 KOO28164.1 - 0.54 10.4 7.7 24 5.1 0.3 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF4079) Wzy_C_2 PF11846.8 KOO28164.1 - 2.5 8.0 11.0 0.093 12.6 0.5 3.1 3 1 0 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal tRNA-synt_1e PF01406.19 KOO28165.1 - 1.6e-112 375.8 0.0 3.4e-112 374.7 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 KOO28165.1 - 2.7e-06 26.4 0.3 0.00011 21.1 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KOO28165.1 - 0.0056 15.0 0.0 0.011 14.0 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.18 KOO28165.1 - 0.27 10.1 0.1 3.4 6.5 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class I (K) ROK PF00480.20 KOO28166.1 - 2.4e-39 135.6 0.0 3.8e-39 134.9 0.0 1.3 1 1 0 1 1 1 1 ROK family Glucokinase PF02685.16 KOO28166.1 - 0.035 13.1 0.1 0.035 13.1 0.1 2.7 3 0 0 3 3 3 0 Glucokinase PRK PF00485.18 KOO28167.1 - 1.7e-49 168.3 0.1 2.1e-49 167.9 0.1 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CoaE PF01121.20 KOO28167.1 - 0.00021 21.0 0.0 0.14 11.8 0.0 2.3 2 0 0 2 2 2 2 Dephospho-CoA kinase AAA_18 PF13238.6 KOO28167.1 - 0.0003 21.3 0.0 0.00076 20.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KOO28167.1 - 0.0015 17.9 0.0 0.0026 17.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 KOO28167.1 - 0.0079 16.4 0.0 0.016 15.4 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KOO28167.1 - 0.063 13.7 0.0 1.3 9.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO28167.1 - 0.076 13.4 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 KOO28167.1 - 0.08 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 KOO28167.1 - 0.1 12.3 0.1 4.8 6.9 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase CPT PF07931.12 KOO28167.1 - 0.13 12.0 0.1 0.42 10.4 0.0 1.8 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein BACK PF07707.15 KOO28168.1 - 6.3e-16 58.3 0.0 4.8e-15 55.5 0.0 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 KOO28168.1 - 1.4e-12 47.8 0.0 3.2e-12 46.6 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain MATH PF00917.26 KOO28168.1 - 4.3e-10 39.7 0.0 7e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 MATH domain Paramyx_P_V_C PF03210.13 KOO28169.1 - 0.043 13.6 0.0 0.097 12.5 0.0 1.6 1 0 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal WD40 PF00400.32 KOO28170.1 - 3.2e-09 37.2 0.2 2.6e-06 28.0 0.0 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO28170.1 - 0.0017 18.6 0.0 0.59 10.5 0.0 3.4 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 KOO28170.1 - 0.0018 17.4 0.2 0.0029 16.7 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1513) Nup160 PF11715.8 KOO28170.1 - 0.066 11.9 0.0 0.092 11.4 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 EamA PF00892.20 KOO28171.1 - 3e-13 50.1 21.3 2e-09 37.8 6.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 KOO28171.1 - 3e-07 30.1 3.1 0.0024 17.3 1.8 2.0 2 0 0 2 2 2 2 Triose-phosphate Transporter family PUNUT PF16913.5 KOO28171.1 - 5.8 6.0 10.8 0.47 9.6 1.0 2.3 3 0 0 3 3 3 0 Purine nucleobase transmembrane transport NAD_binding_6 PF08030.12 KOO28172.1 - 5.3e-17 62.4 0.0 5.2e-16 59.1 0.0 2.4 2 1 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KOO28172.1 - 4.6e-14 52.6 6.6 1.1e-13 51.3 6.6 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component WW PF00397.26 KOO28172.1 - 1.5e-08 34.6 3.8 1.5e-08 34.6 3.8 2.3 2 0 0 2 2 2 1 WW domain FAD_binding_8 PF08022.12 KOO28172.1 - 4.5e-07 29.9 0.0 9.6e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain TMEM72 PF16054.5 KOO28172.1 - 0.19 11.4 1.5 0.48 10.1 1.5 1.6 1 0 0 1 1 1 0 Transmembrane protein family 72 Zip PF02535.22 KOO28173.1 - 3.5e-19 69.2 16.3 3.9e-10 39.5 4.9 2.4 1 1 1 2 2 2 2 ZIP Zinc transporter KH_1 PF00013.29 KOO28174.1 - 4.7e-84 276.2 33.2 3.5e-13 49.2 0.7 10.8 11 0 0 11 11 11 8 KH domain KH_2 PF07650.17 KOO28174.1 - 1.4e-16 60.1 33.5 0.0052 16.6 0.6 8.1 6 2 2 8 8 8 7 KH domain SLS PF14611.6 KOO28174.1 - 3.9e-15 56.3 6.6 0.00029 20.7 0.1 5.7 3 2 3 6 6 6 4 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.6 KOO28174.1 - 5.1e-09 35.9 19.1 0.0062 16.4 0.2 6.5 6 0 0 6 6 6 4 KH domain MOEP19 PF16005.5 KOO28174.1 - 3.4e-08 33.4 0.8 1.3 9.0 0.0 6.4 3 2 3 6 6 6 2 KH-like RNA-binding domain KH_5 PF13184.6 KOO28174.1 - 0.11 12.6 11.4 17 5.6 0.0 6.4 7 0 0 7 7 7 0 NusA-like KH domain Secretin_N PF03958.17 KOO28174.1 - 0.21 12.0 14.6 3.2 8.2 0.2 6.3 5 2 2 7 7 7 0 Bacterial type II/III secretion system short domain BMC PF00936.19 KOO28174.1 - 0.25 11.3 0.1 0.25 11.3 0.1 7.4 8 0 0 8 8 8 0 BMC domain SNARE_assoc PF09335.11 KOO28175.1 - 7.1e-15 55.6 0.2 7.1e-15 55.6 0.2 2.0 3 0 0 3 3 3 1 SNARE associated Golgi protein RCC1 PF00415.18 KOO28176.1 - 2.2e-72 239.5 21.0 5.3e-14 52.6 0.1 8.5 7 1 1 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO28176.1 - 2.1e-35 119.8 39.7 2.3e-07 30.4 0.4 9.1 9 0 0 9 9 9 8 Regulator of chromosome condensation (RCC1) repeat EF-hand_1 PF00036.32 KOO28177.1 - 1.7e-10 39.7 1.2 1.2e-05 24.5 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO28177.1 - 4.5e-10 39.8 0.0 6.5e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO28177.1 - 7.2e-09 34.9 0.3 0.0016 18.2 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO28177.1 - 2.7e-07 30.3 0.0 4.7e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO28177.1 - 2.9e-05 23.4 2.1 0.00027 20.3 0.4 2.4 2 0 0 2 2 2 1 EF hand PG_binding_1 PF01471.18 KOO28177.1 - 0.033 14.4 0.3 0.18 12.1 0.3 2.0 1 1 0 1 1 1 0 Putative peptidoglycan binding domain Pkinase PF00069.25 KOO28178.1 - 2.2e-39 135.5 0.0 3e-39 135.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28178.1 - 1.9e-21 76.5 0.0 3.3e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO28178.1 - 8.8e-06 25.2 0.0 2.9e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOO28178.1 - 0.015 15.2 0.1 0.062 13.2 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO28178.1 - 0.026 13.9 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOO28178.1 - 0.047 12.6 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain zf-Nse PF11789.8 KOO28178.1 - 0.18 11.7 0.2 0.35 10.7 0.2 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Nudix_hydro PF18290.1 KOO28179.1 - 1.2e-24 86.1 0.0 1.9e-24 85.4 0.0 1.4 1 0 0 1 1 1 1 Nudix hydrolase domain NUDIX PF00293.28 KOO28179.1 - 3e-17 62.9 0.0 4.4e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain PWWP PF00855.17 KOO28180.1 - 2e-14 53.8 0.3 2e-14 53.8 0.3 2.7 2 1 0 2 2 2 1 PWWP domain HMG_box PF00505.19 KOO28180.1 - 1.2e-08 35.2 9.8 1.9e-07 31.4 0.0 3.5 3 0 0 3 3 3 2 HMG (high mobility group) box CHDNT PF08073.12 KOO28180.1 - 5.7e-05 23.0 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 CHDNT (NUC034) domain HMG_box_2 PF09011.10 KOO28180.1 - 0.00064 20.3 6.9 0.027 15.0 0.2 3.3 2 1 1 3 3 3 2 HMG-box domain Rrn6 PF10214.9 KOO28180.1 - 0.0071 14.9 1.2 0.0084 14.7 1.2 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor CDC45 PF02724.14 KOO28180.1 - 0.053 11.8 0.5 0.076 11.3 0.5 1.2 1 0 0 1 1 1 0 CDC45-like protein LBR_tudor PF09465.10 KOO28180.1 - 0.19 11.5 0.1 0.51 10.2 0.0 1.7 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain RelB_N PF18506.1 KOO28180.1 - 6.1 6.7 8.0 0.68 9.8 0.2 2.8 3 0 0 3 3 3 0 RelB Antitoxin alpha helical domain Band_7 PF01145.25 KOO28181.1 - 8.8e-20 71.4 4.2 1.2e-19 71.0 4.2 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 KOO28181.1 - 0.0056 16.4 0.4 0.0081 15.9 0.4 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family Fez1 PF06818.15 KOO28182.1 - 0.06 13.8 6.6 0.091 13.2 6.6 1.2 1 0 0 1 1 1 0 Fez1 Sipho_Gp157 PF05565.11 KOO28182.1 - 0.081 12.9 3.0 0.17 11.9 3.0 1.5 1 0 0 1 1 1 0 Siphovirus Gp157 PID PF00640.23 KOO28182.1 - 0.16 12.0 0.2 0.24 11.4 0.2 1.2 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF5320 PF17253.2 KOO28182.1 - 0.58 11.2 5.0 2.1 9.4 0.3 3.3 3 1 1 4 4 4 0 Family of unknown function (DUF5320) PKcGMP_CC PF16808.5 KOO28182.1 - 0.78 9.7 4.7 0.31 10.9 0.9 2.4 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase VPS13_C PF16909.5 KOO28183.1 - 3.3e-48 163.8 0.1 3.3e-43 147.5 0.0 2.5 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13_mid_rpt PF16910.5 KOO28183.1 - 1.5e-39 135.8 0.0 1.5e-30 106.3 0.0 4.3 4 0 0 4 4 4 3 Repeating coiled region of VPS13 Chorein_N PF12624.7 KOO28183.1 - 6.5e-31 106.8 0.0 2.7e-30 104.9 0.0 2.1 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 KOO28183.1 - 2.7e-29 102.7 0.0 1.6e-13 51.0 0.0 3.2 3 0 0 3 3 3 2 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 KOO28183.1 - 4.7e-21 75.4 0.0 2.2e-16 60.0 0.0 3.9 4 0 0 4 4 4 2 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 KOO28183.1 - 0.018 15.4 0.1 0.23 11.8 0.0 2.8 2 0 0 2 2 2 0 Autophagy-related protein C terminal domain Fea1 PF07692.11 KOO28184.1 - 0.002 17.2 0.1 0.0036 16.4 0.1 1.5 1 1 0 1 1 1 1 Low iron-inducible periplasmic protein FAM163 PF15069.6 KOO28184.1 - 0.022 15.2 0.8 0.039 14.4 0.8 1.4 1 0 0 1 1 1 0 FAM163 family HemY_N PF07219.13 KOO28184.1 - 1.7 8.9 6.4 8.6 6.6 0.0 3.0 4 0 0 4 4 4 0 HemY protein N-terminus EMP70 PF02990.16 KOO28185.1 - 1.1e-158 529.1 12.9 1.5e-158 528.7 12.9 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 TMEM219 PF14940.6 KOO28185.1 - 0.047 13.3 2.0 0.095 12.3 2.0 1.4 1 0 0 1 1 1 0 Transmembrane 219 Actin PF00022.19 KOO28186.1 - 6.7e-91 304.9 0.0 3.7e-89 299.2 0.0 2.0 1 1 0 1 1 1 1 Actin FtsA PF14450.6 KOO28186.1 - 0.0094 16.4 0.0 0.036 14.5 0.0 2.1 2 1 0 2 2 2 1 Cell division protein FtsA His_Phos_2 PF00328.22 KOO28187.1 - 0.0018 17.7 0.2 0.0025 17.3 0.2 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RR_TM4-6 PF06459.12 KOO28187.1 - 0.098 12.5 6.4 0.13 12.0 6.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Snf7 PF03357.21 KOO28188.1 - 3.1e-58 196.2 83.2 2e-22 79.6 12.4 5.1 3 1 2 5 5 5 5 Snf7 Syntaxin_2 PF14523.6 KOO28188.1 - 0.00057 20.2 18.8 0.34 11.3 0.0 6.1 3 2 2 6 6 6 3 Syntaxin-like protein Regnase_1_C PF18561.1 KOO28188.1 - 0.021 14.6 11.0 3.2 7.6 0.2 4.5 4 0 0 4 4 4 0 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain Arm_3 PF16186.5 KOO28188.1 - 0.035 13.7 10.1 18 5.0 0.2 4.7 4 0 0 4 4 4 0 Atypical Arm repeat Wyosine_form PF08608.12 KOO28188.1 - 0.048 14.0 3.2 4 7.9 0.1 3.7 3 0 0 3 3 3 0 Wyosine base formation DUF3697 PF12478.8 KOO28188.1 - 0.082 13.0 0.2 22 5.3 0.0 2.5 2 0 0 2 2 2 0 Ubiquitin-associated protein 2 Apolipo_F PF15148.6 KOO28188.1 - 0.13 11.8 20.3 0.038 13.5 0.9 4.6 4 1 1 5 5 5 0 Apolipoprotein F DUF1507 PF07408.11 KOO28188.1 - 0.33 10.9 6.6 0.65 9.9 0.1 4.3 5 0 0 5 5 4 0 Protein of unknown function (DUF1507) GP57 PF17594.2 KOO28188.1 - 1.2 9.0 20.6 0.66 9.8 0.5 5.8 4 2 0 4 4 4 0 Phage Tail fiber assembly helper gene product 57 NRBF2_MIT PF17169.4 KOO28188.1 - 1.2 9.4 16.7 0.8 10.0 2.0 3.7 3 0 0 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 ASL_C PF08328.11 KOO28188.1 - 2.3 8.4 21.3 0.83 9.8 3.2 4.4 4 0 0 4 4 4 0 Adenylosuccinate lyase C-terminal NPV_P10 PF05531.12 KOO28188.1 - 2.5 8.6 15.1 4.2 7.9 1.2 5.1 5 1 1 6 6 6 0 Nucleopolyhedrovirus P10 protein bZIP_C PF12498.8 KOO28188.1 - 5.2 8.1 12.7 13 6.7 0.1 4.5 3 2 1 4 4 4 0 Basic leucine-zipper C terminal ABC1 PF03109.16 KOO28189.1 - 2.8e-29 101.7 0.0 6.7e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO28189.1 - 0.00017 21.6 0.1 0.00017 21.6 0.1 2.5 2 2 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO28189.1 - 0.00061 19.2 0.0 0.043 13.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Methyltransf_23 PF13489.6 KOO28190.1 - 7.6e-22 77.9 0.0 1.2e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Peptidase_S8 PF00082.22 KOO28190.1 - 3.4e-20 72.5 15.2 7.7e-20 71.3 10.0 3.4 2 1 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 KOO28190.1 - 2.9e-16 59.3 0.1 1.5e-07 31.3 0.0 2.6 2 0 0 2 2 2 2 Proprotein convertase P-domain Methyltransf_11 PF08241.12 KOO28190.1 - 1e-11 45.3 0.0 2.6e-11 44.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO28190.1 - 7.7e-11 42.6 0.0 3.2e-10 40.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO28190.1 - 7.7e-08 32.0 0.0 1.3e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 KOO28190.1 - 1.5e-06 28.9 0.0 5.8e-06 27.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO28190.1 - 0.00093 19.0 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF4448 PF14610.6 KOO28190.1 - 0.13 12.0 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Fer4_13 PF13370.6 KOO28191.1 - 2e-12 47.4 2.6 2e-12 47.4 2.6 2.1 2 0 0 2 2 2 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 KOO28191.1 - 2.6e-07 31.3 5.8 3.3e-07 30.9 2.8 2.4 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4 PF00037.27 KOO28191.1 - 0.014 15.2 3.4 0.36 10.7 0.6 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_21 PF14697.6 KOO28191.1 - 0.12 12.5 3.7 0.37 10.9 0.3 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 KOO28191.1 - 1.3 9.7 7.3 1.4 9.6 4.6 2.3 2 1 0 2 2 2 0 4Fe-4S dicluster domain Sigma70_r2 PF04542.14 KOO28192.1 - 1.7e-13 50.1 0.0 4.3e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r3 PF04539.16 KOO28192.1 - 3.8e-08 33.3 0.8 4.1e-07 30.0 0.4 2.3 2 0 0 2 2 2 1 Sigma-70 region 3 Sigma70_r4 PF04545.16 KOO28192.1 - 3.3e-06 26.5 7.9 0.0087 15.6 0.2 3.7 4 0 0 4 4 4 3 Sigma-70, region 4 HTH_AsnC-type PF13404.6 KOO28192.1 - 0.0014 18.4 4.3 0.2 11.5 0.1 3.0 3 0 0 3 3 3 2 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 KOO28192.1 - 0.0078 15.8 1.8 0.15 11.6 0.1 2.9 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_10 PF04967.12 KOO28192.1 - 0.021 14.6 0.4 0.5 10.2 0.0 2.9 3 1 0 3 3 3 0 HTH DNA binding domain HTH_31 PF13560.6 KOO28192.1 - 0.029 14.7 6.7 1.2 9.5 0.3 3.1 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_3 PF01381.22 KOO28192.1 - 0.061 13.4 0.6 9.2 6.4 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix Kelch_3 PF13415.6 KOO28193.1 - 1.8e-21 75.9 4.2 9e-09 35.4 0.0 6.3 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO28193.1 - 1.4e-20 73.0 3.0 2.5e-09 37.0 0.0 6.1 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO28193.1 - 1.1e-16 60.4 1.9 0.00045 20.1 0.0 5.6 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 KOO28193.1 - 1.6e-09 37.7 0.2 2.2e-05 24.6 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 KOO28193.1 - 1.9e-07 30.6 3.9 0.0075 15.8 0.0 5.0 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 KOO28193.1 - 4.2e-05 23.3 1.0 3.6 7.7 0.0 4.7 5 0 0 5 5 5 2 Kelch motif RAG2 PF03089.14 KOO28193.1 - 0.037 13.0 0.0 1.2 8.1 0.0 2.4 2 0 0 2 2 2 0 Recombination activating protein 2 ParB PF08775.10 KOO28194.1 - 0.0048 17.4 2.8 0.045 14.2 1.8 2.0 1 1 1 2 2 2 1 ParB family DUF1978 PF09321.10 KOO28194.1 - 0.0051 16.2 5.1 0.0066 15.8 5.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1978) SAC3_GANP PF03399.16 KOO28194.1 - 0.023 14.1 2.5 0.031 13.7 2.5 1.1 1 0 0 1 1 1 0 SAC3/GANP family RNA_pol_Rpc82 PF05645.13 KOO28194.1 - 0.039 13.7 0.3 0.063 13.0 0.3 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 Fez1 PF06818.15 KOO28194.1 - 0.053 14.0 11.1 0.08 13.4 11.1 1.3 1 0 0 1 1 1 0 Fez1 Atg14 PF10186.9 KOO28194.1 - 0.24 10.5 10.8 0.29 10.2 9.4 1.6 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 KOO28194.1 - 3 5.7 3.7 3.5 5.4 3.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3584 PF12128.8 KOO28194.1 - 5.1 4.5 17.4 6.3 4.2 17.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Sel1 PF08238.12 KOO28196.1 - 1.5e-53 178.0 38.7 1.5e-07 31.9 0.2 9.4 9 0 0 9 9 9 9 Sel1 repeat U-box PF04564.15 KOO28196.1 - 1.2e-16 60.6 0.0 1.8e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO28196.1 - 0.00032 20.5 0.0 0.00064 19.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Blt1_C PF17183.4 KOO28196.1 - 0.011 15.3 0.9 1.6e+02 2.0 0.0 6.0 7 0 0 7 7 7 0 Get5 carboxyl domain TFIIA PF03153.13 KOO28196.1 - 6.1 6.7 15.3 8.6 6.2 15.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TIG PF01833.24 KOO28197.1 - 7.8e-24 83.6 3.8 5.4e-05 23.2 0.0 7.7 6 2 0 6 6 6 6 IPT/TIG domain Bact_lectin PF18483.1 KOO28197.1 - 6.1e-06 26.4 0.0 0.0069 16.4 0.0 2.3 2 0 0 2 2 2 2 Bacterial lectin Anth_Ig PF05587.13 KOO28197.1 - 0.00084 19.6 0.0 0.0088 16.3 0.0 2.7 3 0 0 3 3 3 1 Anthrax receptor extracellular domain DUF543 PF04418.12 KOO28198.1 - 1.3e-20 73.2 0.2 1.4e-20 73.0 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) zf-MYND PF01753.18 KOO28199.1 - 0.0007 19.6 8.6 0.0016 18.4 8.6 1.7 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.6 KOO28199.1 - 0.017 15.2 5.2 0.043 13.9 5.2 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 TIG PF01833.24 KOO28200.1 - 0.00031 20.8 0.0 0.04 14.0 0.0 2.7 2 0 0 2 2 2 2 IPT/TIG domain Stealth_CR1 PF17101.5 KOO28200.1 - 0.17 11.6 0.6 0.41 10.4 0.6 1.7 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 DUF3496 PF12001.8 KOO28201.1 - 0.2 12.0 7.6 0.078 13.4 3.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) Pho88 PF10032.9 KOO28202.1 - 1.2e-23 83.3 0.5 1.4e-23 83.1 0.5 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Sel1 PF08238.12 KOO28203.1 - 8.6e-29 99.3 30.7 2.3e-07 31.3 1.0 6.6 6 0 0 6 6 6 6 Sel1 repeat U-box PF04564.15 KOO28203.1 - 1.2e-17 63.9 0.0 1.7e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO28203.1 - 0.00033 20.4 0.0 0.00066 19.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO28203.1 - 0.035 14.2 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TFIIA PF03153.13 KOO28203.1 - 4.2 7.3 13.0 6 6.7 13.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TIG PF01833.24 KOO28204.1 - 2.6e-24 85.1 25.0 1.2e-07 31.7 0.1 7.7 7 1 1 8 8 8 5 IPT/TIG domain REJ PF02010.15 KOO28204.1 - 2.7e-08 33.0 0.0 2e-05 23.6 0.0 2.3 1 1 1 2 2 2 2 REJ domain TIG_plexin PF17960.1 KOO28204.1 - 3.6e-05 23.7 0.3 0.1 12.6 0.0 4.3 4 0 0 4 4 4 1 TIG domain Qn_am_d_aIII PF09099.10 KOO28204.1 - 0.071 13.5 1.5 30 5.1 0.4 4.8 4 1 0 4 4 4 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III TatD_DNase PF01026.21 KOO28205.1 - 7.8e-33 113.9 0.0 1.4e-32 113.1 0.0 1.4 1 0 0 1 1 1 1 TatD related DNase ThiF PF00899.21 KOO28205.1 - 4.8e-29 101.4 0.0 7.4e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 KOO28205.1 - 0.0039 17.5 1.1 0.08 13.2 1.1 2.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 KOO28205.1 - 0.0055 17.1 0.5 0.015 15.7 0.5 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding DUF3322 PF11795.8 KOO28205.1 - 0.63 10.0 3.2 0.27 11.2 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) 3HCDH_N PF02737.18 KOO28205.1 - 0.99 9.3 3.1 0.9 9.4 0.1 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Peptidase_M17_N PF02789.17 KOO28205.1 - 4.8 7.0 7.5 1.6 8.6 0.2 3.2 2 1 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain Glyco_transf_8 PF01501.20 KOO28206.1 - 2.2e-07 30.7 0.1 2.9e-07 30.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Ca_chan_IQ PF08763.11 KOO28206.1 - 0.14 12.4 0.1 0.29 11.4 0.1 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel IQ domain EF-hand_6 PF13405.6 KOO28207.1 - 2.7e-21 73.6 9.4 1.7e-05 24.3 0.4 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO28207.1 - 5.2e-19 66.3 10.9 8.9e-05 21.8 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO28207.1 - 9.5e-17 61.2 5.5 2.7e-08 34.1 1.4 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO28207.1 - 1.8e-14 53.3 1.2 4.2e-07 29.7 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO28207.1 - 1.2e-11 43.5 15.0 1.3e-05 24.5 0.5 4.4 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KOO28207.1 - 0.098 13.0 0.1 25 5.3 0.0 3.3 3 1 1 4 4 4 0 EF-hand domain Armet PF10208.9 KOO28207.1 - 0.1 12.6 0.0 0.57 10.1 0.0 2.0 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding EF-hand_4 PF12763.7 KOO28207.1 - 0.57 10.2 3.2 5.1 7.1 0.0 2.8 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand UFD1 PF03152.14 KOO28208.1 - 4.9e-42 143.3 0.0 7e-42 142.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CAP_GLY PF01302.25 KOO28208.1 - 6.9e-21 74.0 1.4 1.5e-20 73.0 1.4 1.6 1 0 0 1 1 1 1 CAP-Gly domain UBX PF00789.20 KOO28208.1 - 1.8e-15 56.9 0.0 3.2e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 UBX domain CDC48_2 PF02933.17 KOO28208.1 - 0.031 14.1 0.5 0.11 12.4 0.5 1.9 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 DUF2878 PF11086.8 KOO28208.1 - 0.21 11.8 0.1 0.33 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2878) Spore_coat_CotO PF14153.6 KOO28208.1 - 5.5 6.9 8.4 8.1 6.3 8.4 1.1 1 0 0 1 1 1 0 Spore coat protein CotO CBF PF03914.17 KOO28209.1 - 2.7e-47 161.0 0.5 1.6e-46 158.5 0.1 2.3 2 0 0 2 2 2 1 CBF/Mak21 family MMS19_N PF14500.6 KOO28209.1 - 0.02 14.5 0.1 0.62 9.6 0.1 2.2 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II Adaptin_N PF01602.20 KOO28210.1 - 2.6e-38 131.9 0.0 3.3e-38 131.5 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region LUC7 PF03194.15 KOO28212.1 - 0.72 9.5 4.9 1.1 8.9 4.9 1.3 1 0 0 1 1 1 0 LUC7 N_terminus Mito_carr PF00153.27 KOO28213.1 - 1.5e-30 105.0 1.7 7.5e-16 57.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HVSL PF09749.9 KOO28214.1 - 0.11 11.9 0.2 0.17 11.3 0.2 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein Gly_transf_sug PF04488.15 KOO28215.1 - 2.6e-10 40.8 0.0 5e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif ShK PF01549.24 KOO28215.1 - 2.3e-09 37.6 7.8 2.3e-09 37.6 7.8 1.8 2 0 0 2 2 2 1 ShK domain-like Caps_synth PF05704.12 KOO28215.1 - 0.0057 16.1 0.0 0.0078 15.6 0.0 1.1 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.7 KOO28215.1 - 0.0061 15.9 0.0 0.0086 15.4 0.0 1.1 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain DUF1565 PF07602.11 KOO28216.1 - 0.08 12.3 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) 6PF2K PF01591.18 KOO28217.1 - 6.2e-38 130.3 0.3 1.4e-28 99.7 0.0 2.1 1 1 1 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOO28217.1 - 4.4e-14 52.6 0.1 1.6e-10 41.0 0.0 3.1 3 0 0 3 3 3 2 Histidine phosphatase superfamily (branch 1) DUF3274 PF11678.8 KOO28217.1 - 0.03 13.6 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3274) AAA_33 PF13671.6 KOO28217.1 - 0.063 13.4 0.1 0.22 11.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain Redoxin PF08534.10 KOO28218.1 - 6.3e-14 51.9 0.1 9.9e-14 51.3 0.1 1.3 1 0 0 1 1 1 1 Redoxin DUF4907 PF16250.5 KOO28218.1 - 0.062 13.2 0.0 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4907) DUF5327 PF17261.2 KOO28219.1 - 1.6 9.5 4.2 0.95 10.2 1.6 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Rh5 PF18515.1 KOO28220.1 - 0.075 12.3 0.0 0.097 11.9 0.0 1.1 1 0 0 1 1 1 0 Rh5 coiled-coil domain Ank_4 PF13637.6 KOO28220.1 - 0.09 13.4 0.0 2.1 9.0 0.0 2.2 1 1 1 2 2 2 0 Ankyrin repeats (many copies) DUF1997 PF09366.10 KOO28221.1 - 0.016 15.4 0.0 0.019 15.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1997) CDC37_C PF08564.10 KOO28222.1 - 5e-16 58.7 0.0 1.6e-06 28.1 0.1 2.6 2 0 0 2 2 2 2 Cdc37 C terminal domain UBM PF14377.6 KOO28222.1 - 0.015 14.8 0.7 0.015 14.8 0.7 3.8 5 0 0 5 5 5 0 Ubiquitin binding region Myc-LZ PF02344.15 KOO28222.1 - 0.05 13.7 1.2 0.13 12.4 1.2 1.7 1 0 0 1 1 1 0 Myc leucine zipper domain Takusan PF04822.13 KOO28222.1 - 0.15 11.9 1.7 0.25 11.3 1.2 1.7 1 1 0 1 1 1 0 Takusan Lzipper-MIP1 PF14389.6 KOO28222.1 - 1.4 9.2 6.8 0.21 11.9 2.3 2.0 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 OmpH PF03938.14 KOO28222.1 - 1.7 9.0 8.5 3.1 8.1 8.5 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Vps39_2 PF10367.9 KOO28222.1 - 1.9 9.0 4.2 24 5.4 0.0 3.2 3 1 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 APG6_N PF17675.1 KOO28222.1 - 2.5 8.6 11.1 4.7 7.8 11.1 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4404 PF14357.6 KOO28222.1 - 6 7.6 8.6 3.9 8.2 6.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DNA_topoisoIV PF00521.20 KOO28224.1 - 3.1e-141 471.1 0.0 3.8e-141 470.9 0.0 1.1 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 KOO28224.1 - 6.4e-25 86.4 0.0 3.6e-10 39.1 0.0 4.3 4 0 0 4 4 4 3 DNA gyrase C-terminal domain, beta-propeller LigA PF07746.11 KOO28224.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit FliT PF05400.13 KOO28224.1 - 1.4 9.8 8.5 2.6 8.9 7.2 2.2 2 0 0 2 2 2 0 Flagellar protein FliT DNA_gyraseA_C PF03989.13 KOO28225.1 - 6.7e-28 95.9 0.5 4.2e-13 48.6 0.1 2.1 2 0 0 2 2 2 2 DNA gyrase C-terminal domain, beta-propeller TPR_2 PF07719.17 KOO28226.1 - 2.1e-10 39.9 7.7 0.013 15.6 0.3 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28226.1 - 1.9e-09 36.9 2.7 0.015 15.1 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28226.1 - 5.1e-07 30.2 27.4 4.4e-06 27.3 9.9 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28226.1 - 0.00031 21.0 5.3 0.093 13.0 0.6 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28226.1 - 0.003 17.7 1.6 0.5 10.7 0.1 3.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28226.1 - 0.027 15.0 2.1 0.027 15.0 2.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28226.1 - 0.05 13.3 0.8 1 9.1 0.0 3.0 2 1 1 3 3 3 0 TPR repeat TPR_14 PF13428.6 KOO28226.1 - 0.054 14.3 2.4 0.054 14.3 2.4 4.9 4 1 1 5 5 4 0 Tetratricopeptide repeat AlkA_N PF06029.11 KOO28226.1 - 0.06 13.6 1.3 9.8 6.5 0.3 2.3 2 0 0 2 2 2 0 AlkA N-terminal domain DUF4856 PF16148.5 KOO28226.1 - 0.066 12.2 0.5 0.2 10.6 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4856) TPR_6 PF13174.6 KOO28226.1 - 0.081 13.6 4.8 37 5.2 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28226.1 - 0.22 12.0 0.9 12 6.6 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28226.1 - 0.32 11.2 20.3 0.13 12.4 1.2 4.4 3 1 1 4 4 4 0 Tetratricopeptide repeat ABC_tran PF00005.27 KOO28227.1 - 1.6e-29 103.2 0.0 3.6e-29 102.0 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 KOO28227.1 - 1.5e-08 34.8 0.7 0.0039 17.1 0.1 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO28227.1 - 6.7e-07 29.0 0.1 7.9e-05 22.2 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 KOO28227.1 - 3.7e-05 23.8 0.0 5.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Dynamin family ABC_tran_Xtn PF12848.7 KOO28227.1 - 0.00015 21.7 0.1 0.00045 20.2 0.1 1.8 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 KOO28227.1 - 0.00088 19.8 0.9 0.0026 18.3 0.9 2.0 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 KOO28227.1 - 0.0013 18.5 0.0 0.0025 17.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KOO28227.1 - 0.0063 16.6 0.1 0.011 15.8 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KOO28227.1 - 0.017 15.4 0.1 0.036 14.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO28227.1 - 0.018 15.4 0.0 0.029 14.8 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 KOO28227.1 - 0.029 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase cobW PF02492.19 KOO28227.1 - 0.052 13.1 0.0 0.97 9.0 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 KOO28227.1 - 0.066 13.5 0.1 0.13 12.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 KOO28227.1 - 0.091 12.8 0.0 0.44 10.6 0.0 2.0 2 1 0 2 2 2 0 Helicase HerA, central domain AAA_33 PF13671.6 KOO28227.1 - 0.098 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOO28227.1 - 0.1 12.3 0.1 0.26 11.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOO28227.1 - 0.11 12.6 0.0 0.52 10.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOO28227.1 - 0.11 13.1 0.0 0.2 12.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOO28227.1 - 0.13 11.8 0.3 1.5 8.3 0.3 2.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO28227.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_13 PF13166.6 KOO28227.1 - 0.16 10.6 0.0 0.58 8.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 KOO28227.1 - 0.18 11.5 0.0 1.2 8.8 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain LRR_6 PF13516.6 KOO28228.1 - 2.4e-16 58.3 24.5 0.00024 20.9 0.1 8.6 7 1 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.33 KOO28228.1 - 0.00058 20.0 2.0 68 4.6 0.0 6.0 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO28228.1 - 0.0031 17.9 4.5 5 7.7 0.2 4.9 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) HHH_5 PF14520.6 KOO28228.1 - 0.48 11.1 4.3 4.3 8.0 0.0 4.0 5 0 0 5 5 5 0 Helix-hairpin-helix domain DUF676 PF05057.14 KOO28230.1 - 6.7e-20 71.5 0.0 1.8e-19 70.1 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 KOO28230.1 - 1.8e-07 31.3 0.0 2.6e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 KOO28230.1 - 0.00021 21.1 0.0 0.00034 20.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 KOO28230.1 - 0.08 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) zf-CDGSH PF09360.10 KOO28231.1 - 0.087 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Iron-binding zinc finger CDGSH type Ribosomal_S5 PF00333.20 KOO28231.1 - 0.18 11.8 0.3 0.35 10.9 0.3 1.4 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain MMR_HSR1 PF01926.23 KOO28232.1 - 8.1e-17 61.3 0.1 2.1e-15 56.8 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOO28232.1 - 1.9e-11 43.7 0.0 3.8e-09 36.3 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KOO28232.1 - 4.5e-05 23.4 0.1 0.013 15.4 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 KOO28232.1 - 0.0065 16.5 0.1 0.067 13.3 0.2 2.5 2 1 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 KOO28232.1 - 0.011 15.3 0.0 1.2 8.6 0.0 2.9 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KOO28232.1 - 0.036 13.5 0.0 0.072 12.5 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AIG1 PF04548.16 KOO28232.1 - 0.046 13.0 0.1 0.079 12.3 0.1 1.3 1 0 0 1 1 1 0 AIG1 family cobW PF02492.19 KOO28232.1 - 0.14 11.7 0.1 9.7 5.7 0.0 3.0 3 1 1 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 KOO28232.1 - 0.15 12.3 0.0 0.71 10.1 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 KOO28232.1 - 0.61 10.4 6.0 0.23 11.8 0.4 2.9 2 2 0 2 2 2 0 AAA ATPase domain DEAD PF00270.29 KOO28233.1 - 5.8e-41 140.2 0.0 1.1e-40 139.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO28233.1 - 5.4e-31 107.2 0.1 1.9e-30 105.4 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO28233.1 - 0.00021 21.4 0.0 0.00039 20.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KOO28233.1 - 0.019 15.3 0.1 0.17 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KOO28233.1 - 0.04 13.6 0.1 0.068 12.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain UTP25 PF06862.12 KOO28233.1 - 0.12 11.2 0.1 4.5 5.9 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 KOO28233.1 - 0.14 11.5 0.0 0.53 9.6 0.0 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Kinesin PF00225.23 KOO28234.1 - 2.7e-102 342.1 0.0 3.8e-102 341.6 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO28234.1 - 2.5e-23 82.7 0.0 4.3e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding ABC1 PF03109.16 KOO28235.1 - 5.6e-15 55.6 0.0 1.1e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 KOO28235.1 - 0.006 16.0 0.0 0.081 12.3 0.0 2.4 3 0 0 3 3 3 1 Protein kinase domain RIO1 PF01163.22 KOO28235.1 - 0.12 11.9 0.0 0.68 9.5 0.0 2.2 3 0 0 3 3 3 0 RIO1 family TauD PF02668.16 KOO28236.1 - 1.1e-33 117.2 0.4 1.9e-33 116.4 0.1 1.5 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family EF-hand_1 PF00036.32 KOO28236.1 - 1.5e-12 46.1 0.7 2.7e-05 23.4 0.3 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO28236.1 - 3.6e-09 35.7 0.9 0.00027 20.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO28236.1 - 7.6e-09 34.8 0.8 0.002 17.9 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO28236.1 - 9e-09 35.7 0.0 2e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO28236.1 - 1.8e-06 27.7 0.2 0.074 12.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair CsiD PF08943.10 KOO28236.1 - 0.005 16.0 0.0 0.0093 15.1 0.0 1.4 1 0 0 1 1 1 1 CsiD WD40 PF00400.32 KOO28237.1 - 5.1e-51 169.5 14.7 1.6e-09 38.2 0.1 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO28237.1 - 1.4e-15 57.1 2.4 0.0043 16.1 0.1 5.0 1 1 3 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO28237.1 - 3.7e-15 56.0 1.8 0.0022 18.2 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO28237.1 - 3.9e-12 45.8 0.7 0.88 9.6 0.0 5.5 5 0 0 5 5 5 4 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO28237.1 - 1.4e-07 30.2 0.0 0.11 10.9 0.0 3.5 1 1 1 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz DCX PF03607.17 KOO28237.1 - 6.6e-07 29.3 0.0 3.9 7.7 0.0 5.0 5 0 0 5 5 5 1 Doublecortin eIF2A PF08662.11 KOO28237.1 - 1.8e-05 24.7 0.1 0.0074 16.2 0.0 2.6 1 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KOO28237.1 - 0.00036 20.0 0.1 2.9 7.1 0.0 4.3 3 1 2 5 5 5 1 WD40-like domain WD40_3 PF15911.5 KOO28237.1 - 0.0044 17.0 0.4 71 3.5 0.0 4.3 4 0 0 4 4 4 0 WD domain, G-beta repeat rOmpB PF12334.8 KOO28237.1 - 0.0055 16.2 2.4 3 7.2 0.1 3.8 3 1 1 4 4 4 1 Rickettsia outer membrane protein B GspH PF12019.8 KOO28237.1 - 0.049 14.1 1.5 10 6.6 0.0 3.9 1 1 3 4 4 4 0 Type II transport protein GspH dsrm PF00035.26 KOO28237.1 - 0.054 14.2 1.0 58 4.5 0.0 4.0 5 0 0 5 5 5 0 Double-stranded RNA binding motif Dfp1_Him1_M PF08630.10 KOO28237.1 - 0.28 11.4 1.8 18 5.6 0.1 2.9 3 1 0 3 3 3 0 Dfp1/Him1, central region Spc110_C PF18520.1 KOO28237.1 - 0.64 9.7 3.8 44 3.8 0.0 3.7 3 0 0 3 3 3 0 Spindle pole body component 110 C-terminal domain Big_7 PF17957.1 KOO28237.1 - 0.76 10.6 7.6 7.9 7.3 0.9 4.1 2 2 2 4 4 4 0 Bacterial Ig domain Antimicrobial_7 PF08102.11 KOO28237.1 - 0.92 9.8 5.9 86 3.5 0.0 4.8 5 0 0 5 5 5 0 Scorpion antimicrobial peptide Proteasome_A_N PF10584.9 KOO28237.1 - 1.5 8.5 12.0 15 5.4 0.4 5.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Ras PF00071.22 KOO28240.1 - 4.4e-40 136.9 0.0 5.4e-40 136.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO28240.1 - 8.9e-25 87.2 0.0 1.1e-24 86.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO28240.1 - 3.3e-08 33.2 0.0 4.2e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO28240.1 - 1.7e-06 28.1 0.0 2.3e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO28240.1 - 0.0036 17.2 0.0 0.18 11.7 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 KOO28240.1 - 0.012 15.2 0.0 0.028 14.0 0.0 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DNA_pol_E_B PF04042.16 KOO28240.1 - 0.023 14.0 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Gtr1_RagA PF04670.12 KOO28240.1 - 0.028 13.8 0.0 0.033 13.5 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 KOO28240.1 - 0.035 13.8 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain ANAPC5 PF12862.7 KOO28241.1 - 0.00015 21.7 14.2 0.0031 17.5 1.1 3.3 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 5 SET PF00856.28 KOO28242.1 - 1e-12 48.8 0.0 2e-10 41.3 0.0 3.0 2 1 0 2 2 2 1 SET domain PDZ PF00595.24 KOO28242.1 - 0.035 14.5 0.1 0.086 13.2 0.1 1.7 1 0 0 1 1 1 0 PDZ domain AP3D1 PF06375.11 KOO28242.1 - 0.17 12.1 1.3 0.31 11.3 1.3 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Mito_carr PF00153.27 KOO28243.1 - 5.2e-65 215.4 7.1 5.6e-21 74.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein EutK_C PF16365.5 KOO28243.1 - 0.0054 16.7 0.9 0.31 11.1 0.1 2.4 2 0 0 2 2 2 1 Ethanolamine utilization protein EutK C-terminus Serine_protease PF18405.1 KOO28243.1 - 0.12 11.6 5.5 1.5 7.9 0.6 3.4 1 1 3 4 4 4 0 Gammaproteobacterial serine protease RHH_4 PF13467.6 KOO28243.1 - 0.14 12.0 0.0 0.83 9.6 0.0 2.1 2 0 0 2 2 2 0 Ribbon-helix-helix domain tRNA-synt_2d PF01409.20 KOO28244.1 - 1.7e-54 184.9 0.0 1.3e-30 106.7 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 KOO28244.1 - 9.1e-24 83.7 0.0 1.9e-23 82.7 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain AAA_8 PF12780.7 KOO28245.1 - 4.8e-93 311.2 0.0 3.5e-92 308.4 0.0 2.3 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KOO28245.1 - 5.6e-81 270.9 0.1 1.1e-80 269.9 0.1 1.5 1 0 0 1 1 1 1 ATP-binding dynein motor region Dynein_C PF18199.1 KOO28245.1 - 1.1e-65 221.9 0.0 1.9e-65 221.1 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain MT PF12777.7 KOO28245.1 - 2.7e-59 200.9 13.1 4.7e-59 200.2 13.1 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 KOO28245.1 - 2.1e-58 196.8 0.2 5.4e-57 192.2 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_6 PF12774.7 KOO28245.1 - 3.1e-47 161.2 0.0 1.2e-34 119.8 0.0 4.2 3 1 0 3 3 3 2 Hydrolytic ATP binding site of dynein motor region AAA_lid_11 PF18198.1 KOO28245.1 - 1.6e-41 141.8 0.0 6.2e-41 139.9 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO28245.1 - 1.2e-33 115.7 0.0 8.5e-31 106.5 0.0 2.8 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 KOO28245.1 - 6e-25 87.4 0.0 1.5e-24 86.0 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 KOO28245.1 - 1.9e-19 70.0 0.4 6.2e-19 68.4 0.4 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO28245.1 - 1.4e-14 54.3 0.0 1.9e-07 31.2 0.0 3.7 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) Pox_A32 PF04665.12 KOO28245.1 - 0.067 12.6 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein Exostosin PF03016.15 KOO28246.1 - 1.8e-15 56.9 0.0 2.4e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Exostosin family Nuc_sug_transp PF04142.15 KOO28248.1 - 8.3e-88 294.6 12.7 9.6e-88 294.4 12.7 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO28248.1 - 8.2e-06 26.0 5.3 8.2e-06 26.0 5.3 3.3 3 1 0 3 3 3 1 EamA-like transporter family UAA PF08449.11 KOO28248.1 - 0.00082 18.7 11.1 0.0016 17.7 11.1 1.6 1 1 0 1 1 1 1 UAA transporter family DEAD PF00270.29 KOO28249.1 - 5.8e-19 68.5 0.0 1e-18 67.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO28249.1 - 9.6e-09 35.6 0.0 2.6e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain LpxB PF02684.15 KOO28249.1 - 3.6e-08 32.6 0.0 0.002 17.1 0.0 2.3 1 1 1 2 2 2 2 Lipid-A-disaccharide synthetase Pkinase_Tyr PF07714.17 KOO28250.1 - 7.1e-32 110.7 0.0 1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO28250.1 - 5.4e-31 107.9 0.0 8.6e-31 107.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO28250.1 - 0.0006 19.8 0.4 0.0033 17.4 0.1 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Mak10 PF04112.13 KOO28251.1 - 7.8e-24 84.1 0.0 1.5e-17 63.6 0.0 2.3 1 1 1 2 2 2 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase GDA1_CD39 PF01150.17 KOO28252.1 - 2.2e-78 263.9 0.0 2.6e-78 263.6 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Plus-3 PF03126.18 KOO28255.1 - 3.6e-21 75.7 0.0 2.9e-20 72.8 0.0 2.0 1 1 1 2 2 2 1 Plus-3 domain DUF563 PF04577.14 KOO28256.1 - 2.3e-18 67.1 0.4 3.6e-17 63.2 0.4 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF563) L31 PF09784.9 KOO28256.1 - 0.0092 16.4 0.4 0.28 11.6 0.1 3.1 2 1 0 2 2 2 1 Mitochondrial ribosomal protein L31 ResIII PF04851.15 KOO28258.1 - 3.9e-20 72.5 0.0 5.9e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO28258.1 - 9.5e-17 61.3 0.0 1.4e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase FAST_1 PF06743.15 KOO28260.1 - 1.9e-12 47.0 0.0 0.0021 18.0 0.0 4.5 1 1 3 5 5 5 5 FAST kinase-like protein, subdomain 1 DUF2330 PF10092.9 KOO28260.1 - 0.00067 18.8 7.7 0.64 9.1 0.1 3.4 2 2 2 4 4 4 3 Uncharacterized protein conserved in bacteria (DUF2330) DUF1601 PF07671.11 KOO28260.1 - 0.0041 17.0 1.2 2.6 8.0 0.2 4.8 7 0 0 7 7 7 1 Protein of unknown function (DUF1601) Tudor_4 PF18358.1 KOO28260.1 - 0.061 12.9 1.6 4.9 6.8 0.0 3.6 4 0 0 4 4 4 0 Histone methyltransferase Tudor domain HPIP_like PF18524.1 KOO28260.1 - 0.12 12.2 11.5 1.4 8.7 0.1 5.2 6 0 0 6 6 6 0 High potential iron-sulfur protein like Phage_holin_5_1 PF06946.11 KOO28260.1 - 1.3 9.4 13.0 0.77 10.2 0.3 4.4 1 1 3 5 5 5 0 Bacteriophage A118-like holin, Hol118 SKI PF01202.22 KOO28261.1 - 4.1e-24 85.5 0.0 8.4e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 Shikimate kinase DHquinase_I PF01487.15 KOO28261.1 - 4.5e-18 66.3 0.0 4.7e-16 59.7 0.0 2.3 2 0 0 2 2 2 1 Type I 3-dehydroquinase AAA_33 PF13671.6 KOO28261.1 - 0.0014 18.8 0.3 0.0046 17.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KOO28261.1 - 0.079 13.4 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KOO28261.1 - 0.079 13.5 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Acetyltransf_1 PF00583.25 KOO28263.1 - 7e-12 45.6 0.0 9.3e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOO28263.1 - 1.5e-05 24.9 0.0 4.6e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOO28263.1 - 0.00026 21.4 0.0 0.00039 20.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO28263.1 - 0.0052 16.7 0.0 0.0085 16.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein HAD_2 PF13419.6 KOO28264.1 - 1e-16 61.6 0.0 1.2e-16 61.3 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO28264.1 - 8.3e-12 45.8 0.1 9.1e-11 42.4 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO28264.1 - 5.4e-05 23.2 0.0 0.00087 19.3 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 KOO28264.1 - 0.0003 21.2 0.0 0.00044 20.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KOO28264.1 - 0.0064 16.6 0.0 0.081 13.1 0.0 2.5 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Phage_integrase PF00589.22 KOO28265.1 - 0.12 12.1 0.0 0.43 10.3 0.0 1.9 2 0 0 2 2 2 0 Phage integrase family Ion_trans_2 PF07885.16 KOO28266.1 - 4e-15 55.5 1.5 7.5e-15 54.7 1.5 1.4 1 0 0 1 1 1 1 Ion channel EF-hand_7 PF13499.6 KOO28266.1 - 3.6e-05 24.1 0.6 0.055 13.9 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO28266.1 - 5.8e-05 22.7 1.5 0.0029 17.4 0.2 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO28266.1 - 0.00015 21.1 3.9 0.0035 16.8 0.7 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO28266.1 - 0.00033 20.0 2.2 0.028 14.0 0.1 2.6 2 0 0 2 2 2 2 EF hand Phage_TAC_8 PF10666.9 KOO28266.1 - 0.062 13.6 0.5 0.095 13.0 0.5 1.2 1 0 0 1 1 1 0 Phage tail assembly chaperone protein Gp14 ()A118 Ion_trans PF00520.31 KOO28266.1 - 0.077 12.2 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Ion transport protein DUF3461 PF11944.8 KOO28266.1 - 0.15 12.2 0.5 0.24 11.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) DUF4083 PF13314.6 KOO28266.1 - 0.18 11.8 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) DEAD PF00270.29 KOO28268.1 - 9.6e-16 58.0 0.0 1.7e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO28268.1 - 1.4e-13 51.1 0.0 1.4e-12 47.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 KOO28268.1 - 0.00045 20.9 2.9 0.0011 19.7 2.9 1.7 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 KOO28268.1 - 0.018 15.0 0.0 0.047 13.7 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit SPX PF03105.19 KOO28269.1 - 4.8e-08 33.3 1.8 1.9e-06 28.1 0.1 2.0 1 1 1 2 2 2 2 SPX domain TPT PF03151.16 KOO28270.1 - 1.8e-12 47.2 16.7 2.4e-12 46.8 16.7 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 KOO28270.1 - 6.3e-10 38.7 17.1 4.2e-09 36.0 17.7 1.9 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO28270.1 - 1.4e-05 25.3 7.7 1.4e-05 25.3 7.7 2.8 2 2 0 2 2 2 1 EamA-like transporter family Pox_A14 PF05767.12 KOO28270.1 - 0.0069 16.5 0.3 0.063 13.4 0.3 2.5 2 0 0 2 2 2 1 Poxvirus virion envelope protein A14 6PF2K PF01591.18 KOO28271.1 - 9e-49 165.8 0.0 1.3e-48 165.2 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOO28271.1 - 0.027 14.2 3.3 0.086 12.5 1.4 2.5 2 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) Mito_carr PF00153.27 KOO28272.1 - 1.5e-43 146.6 6.9 2.9e-17 62.4 0.3 4.2 3 1 1 4 4 4 4 Mitochondrial carrier protein CLP_protease PF00574.23 KOO28273.1 - 1.1e-49 168.7 0.0 2.3e-49 167.8 0.0 1.4 1 1 0 1 1 1 1 Clp protease TGT PF01702.18 KOO28274.1 - 6.9e-47 160.3 0.0 7.5e-47 160.2 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase CDC4_D PF16856.5 KOO28274.1 - 0.2 11.5 0.9 10 6.1 0.4 2.3 2 0 0 2 2 2 0 Cell division control protein 4 dimerisation domain Filamin PF00630.19 KOO28275.1 - 3.4e-07 31.0 0.0 0.039 14.8 0.0 2.3 2 0 0 2 2 2 2 Filamin/ABP280 repeat PPC PF04151.15 KOO28275.1 - 0.05 14.7 0.5 0.95 10.6 0.1 2.8 3 0 0 3 3 3 0 Bacterial pre-peptidase C-terminal domain DUF1415 PF07209.12 KOO28276.1 - 0.00044 20.0 0.0 0.005 16.6 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1415) HlyIII PF03006.20 KOO28278.1 - 0.0035 17.1 10.0 0.0055 16.4 10.0 1.4 1 0 0 1 1 1 1 Haemolysin-III related ACT_7 PF13840.6 KOO28279.1 - 4.5e-14 52.0 0.1 6.8e-07 29.0 0.0 2.7 3 0 0 3 3 3 2 ACT domain Sds3 PF08598.11 KOO28280.1 - 0.00018 21.6 4.4 0.00022 21.3 4.4 1.2 1 0 0 1 1 1 1 Sds3-like Atg14 PF10186.9 KOO28280.1 - 0.37 9.8 9.9 0.47 9.5 9.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RRM_1 PF00076.22 KOO28281.1 - 4.1e-23 81.0 0.0 6.1e-08 32.4 0.0 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO28281.1 - 1.7e-07 31.0 0.7 0.23 11.3 0.0 3.7 4 0 0 4 4 4 3 Occluded RNA-recognition motif Surp PF01805.20 KOO28281.1 - 1.3e-06 28.3 0.0 2.8e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Surp module RRM_5 PF13893.6 KOO28281.1 - 0.0013 18.3 0.0 0.019 14.5 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 KOO28281.1 - 0.021 14.7 0.0 0.85 9.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Glyco_tranf_2_3 PF13641.6 KOO28281.1 - 2.6 7.9 5.7 6.3 6.6 5.7 1.7 1 1 0 1 1 1 0 Glycosyltransferase like family 2 MRP-S23 PF10484.9 KOO28282.1 - 4.8e-06 26.8 0.0 1.9e-05 24.9 0.0 1.9 2 1 0 2 2 2 1 Mitochondrial ribosomal protein S23 MRP-S25 PF13741.6 KOO28282.1 - 0.0045 16.6 8.4 0.23 11.0 3.5 2.3 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 Ank_2 PF12796.7 KOO28283.1 - 3.8e-39 133.1 0.6 1.1e-11 45.2 0.1 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO28283.1 - 3.4e-22 78.5 0.9 2.9e-08 34.1 0.0 4.4 1 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28283.1 - 2.9e-19 67.1 0.1 0.007 16.8 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 KOO28283.1 - 1.4e-18 66.4 6.9 0.0017 18.8 0.0 6.3 6 1 1 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 KOO28283.1 - 2.5e-18 65.9 2.2 1.2e-06 28.7 0.0 5.1 2 2 3 5 5 5 5 Ankyrin repeats (many copies) CENP-X PF09415.10 KOO28284.1 - 0.083 13.2 0.1 0.21 11.9 0.1 1.7 1 0 0 1 1 1 0 CENP-S associating Centromere protein X DUF5403 PF17395.2 KOO28284.1 - 0.21 11.9 1.1 0.33 11.3 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5403) TPR_2 PF07719.17 KOO28286.1 - 5.1e-08 32.4 1.1 0.00055 19.8 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28286.1 - 1.1e-06 29.2 2.0 3.6e-06 27.5 1.4 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28286.1 - 1.4e-06 27.8 0.1 0.086 12.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28286.1 - 6.7e-06 25.7 0.3 0.0012 18.5 0.0 3.2 3 0 0 3 3 3 1 TPR repeat TPR_19 PF14559.6 KOO28286.1 - 8.1e-05 23.1 5.6 0.13 12.8 0.3 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28286.1 - 0.00017 21.6 1.9 0.00053 20.1 0.8 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_21 PF09976.9 KOO28286.1 - 0.00021 21.0 3.2 0.00021 21.0 3.2 2.9 3 1 0 3 3 3 1 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 KOO28286.1 - 0.00042 20.8 0.2 1.3 9.8 0.1 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28286.1 - 0.0009 19.5 1.0 0.0035 17.6 1.0 2.0 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28286.1 - 0.0024 18.5 1.0 0.17 12.8 0.5 3.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28286.1 - 0.0026 17.8 0.0 0.078 13.2 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28286.1 - 0.006 16.5 1.7 0.039 14.0 0.1 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO28286.1 - 0.024 15.2 4.4 2.5 9.0 1.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO28286.1 - 0.096 12.9 1.3 0.24 11.6 1.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KOO28286.1 - 0.1 12.5 1.5 2.6 8.0 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF523 PF04463.12 KOO28286.1 - 5.7 7.0 5.9 4 7.5 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF523) PocR PF10114.9 KOO28286.1 - 7.9 6.2 8.6 11 5.7 0.2 3.8 3 1 1 4 4 4 0 Sensory domain found in PocR ATG13 PF10033.9 KOO28287.1 - 5.1e-24 85.3 0.0 3.8e-22 79.2 0.0 2.3 1 1 0 1 1 1 1 Autophagy-related protein 13 vATP-synt_AC39 PF01992.16 KOO28288.1 - 2.6e-107 359.2 1.9 2.9e-107 359.1 1.9 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Halo_GVPC PF05465.13 KOO28288.1 - 0.29 11.4 1.5 32 4.9 0.1 2.7 2 0 0 2 2 2 0 Halobacterial gas vesicle protein C (GVPC) repeat MORN PF02493.20 KOO28289.1 - 3.5e-28 95.8 18.0 1.8e-07 30.6 0.2 5.5 5 0 0 5 5 5 5 MORN repeat Pkinase PF00069.25 KOO28290.1 - 4.4e-53 180.3 0.0 5.9e-53 179.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO28290.1 - 1.7e-37 127.4 0.3 1.8e-21 76.0 0.0 4.7 4 1 0 4 4 4 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO28290.1 - 1.1e-25 90.4 0.0 1.6e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO28290.1 - 2e-08 33.8 0.0 4.3e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO28290.1 - 6.8e-06 26.2 2.5 0.0027 17.7 0.0 3.0 2 2 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO28290.1 - 2.5e-05 23.8 0.0 4.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like EF-hand_6 PF13405.6 KOO28290.1 - 4.5e-05 23.1 0.0 0.00019 21.1 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO28290.1 - 0.00027 20.3 0.1 0.0011 18.4 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO28290.1 - 0.00065 20.1 0.0 0.0033 17.9 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair RIO1 PF01163.22 KOO28290.1 - 0.0049 16.5 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 RIO1 family EFhand_Ca_insen PF08726.10 KOO28290.1 - 0.15 12.1 1.4 0.69 10.1 0.0 2.6 3 0 0 3 3 3 0 Ca2+ insensitive EF hand Choline_kinase PF01633.20 KOO28290.1 - 0.2 11.2 0.0 0.38 10.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase CA_like PF10563.9 KOO28292.1 - 1e-61 208.0 1.1 1.5e-61 207.4 1.1 1.3 1 0 0 1 1 1 1 Putative carbonic anhydrase EF-hand_1 PF00036.32 KOO28292.1 - 1.1e-10 40.3 0.3 0.00035 19.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO28292.1 - 4.9e-10 39.1 0.0 0.00021 21.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO28292.1 - 3.1e-09 36.0 0.5 0.0017 18.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO28292.1 - 7.4e-09 35.9 0.0 1.6e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO28292.1 - 3.3e-05 23.2 0.6 0.038 13.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 KOO28292.1 - 0.042 13.8 0.1 11 6.1 0.0 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand CCG PF02754.16 KOO28294.1 - 0.044 14.0 0.2 0.07 13.3 0.2 1.4 1 1 0 1 1 1 0 Cysteine-rich domain Bestrophin PF01062.21 KOO28295.1 - 9.1e-18 64.7 0.5 1.3e-17 64.1 0.5 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel U-box PF04564.15 KOO28296.1 - 1.9e-10 40.8 0.0 3.6e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 U-box domain SAP PF02037.27 KOO28296.1 - 2.5e-08 33.5 0.9 2.5e-08 33.5 0.9 1.8 2 0 0 2 2 2 1 SAP domain Sel1 PF08238.12 KOO28296.1 - 7e-08 32.9 0.6 0.0078 16.9 0.0 3.5 3 0 0 3 3 3 2 Sel1 repeat PSII_Pbs31 PF18240.1 KOO28296.1 - 0.021 15.3 0.5 0.053 14.0 0.5 1.6 1 0 0 1 1 1 0 Photosystem II Psb31 protein zf-NOSIP PF15906.5 KOO28296.1 - 0.038 14.1 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO28296.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Arm PF00514.23 KOO28297.1 - 4.1e-25 87.0 14.2 0.0001 22.2 0.4 6.2 6 0 0 6 6 6 6 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO28297.1 - 0.00043 20.7 22.8 1.9 9.1 3.5 5.9 4 2 2 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 KOO28297.1 - 0.00065 20.0 25.2 0.059 13.8 0.7 3.6 1 1 1 3 3 3 2 HEAT repeats TruB_C PF09142.11 KOO28297.1 - 0.0041 16.9 2.2 0.0041 16.9 2.2 5.3 4 2 2 6 6 6 1 tRNA Pseudouridine synthase II, C terminal DUF1869 PF08956.10 KOO28297.1 - 0.0046 16.8 1.5 1.7 8.6 0.0 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF1869) HEAT PF02985.22 KOO28297.1 - 0.011 15.9 10.5 60 4.3 0.0 6.4 6 1 0 6 6 6 0 HEAT repeat CBM60 PF16841.5 KOO28297.1 - 0.022 15.2 7.2 3.4 8.1 0.0 4.3 3 1 1 4 4 4 0 Ca-dependent carbohydrate-binding module xylan-binding Succ_CoA_lig PF13607.6 KOO28297.1 - 0.095 12.5 20.6 0.29 10.9 1.4 4.0 1 1 4 5 5 5 0 Succinyl-CoA ligase like flavodoxin domain Toprim_4 PF13662.6 KOO28297.1 - 1.3 9.5 12.8 14 6.2 0.1 5.3 2 2 2 5 5 5 0 Toprim domain TRL PF13146.6 KOO28297.1 - 3.6 7.9 16.2 3.8 7.9 0.5 4.7 1 1 4 5 5 5 0 TRL-like protein family GST_N_3 PF13417.6 KOO28298.1 - 1.7e-20 73.2 0.0 8.8e-12 45.3 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO28298.1 - 2.4e-09 37.4 0.0 0.00014 22.1 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KOO28298.1 - 0.00015 22.0 0.0 0.016 15.5 0.0 2.3 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain PAP_fibrillin PF04755.12 KOO28300.1 - 2e-28 99.7 0.0 7.8e-20 71.7 0.0 3.8 2 2 0 2 2 2 2 PAP_fibrillin TPR_10 PF13374.6 KOO28301.1 - 2.4e-88 287.9 36.7 7.8e-13 47.9 0.4 10.0 10 0 0 10 10 9 9 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28301.1 - 2.7e-81 267.9 58.8 9.4e-17 61.1 1.8 7.8 3 2 6 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28301.1 - 4.1e-31 104.7 29.7 0.0003 20.6 0.3 9.7 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO28301.1 - 2.8e-29 102.6 13.7 8.1e-11 41.9 0.8 4.1 1 1 3 4 4 4 4 MalT-like TPR region TPR_2 PF07719.17 KOO28301.1 - 1.1e-28 96.9 18.1 0.0029 17.6 0.1 9.6 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28301.1 - 4.1e-27 92.9 8.1 0.012 15.4 0.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28301.1 - 5.3e-25 85.5 2.0 0.037 14.2 0.0 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28301.1 - 9.5e-20 71.0 48.5 0.00015 22.3 4.5 8.9 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_3 PF07720.12 KOO28301.1 - 1.5e-14 53.6 0.1 1.9 8.6 0.0 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28301.1 - 4.4e-11 42.3 9.2 0.32 10.7 0.0 8.8 9 0 0 9 9 9 3 TPR repeat TPR_14 PF13428.6 KOO28301.1 - 1.1e-09 38.2 41.2 0.37 11.7 0.6 10.2 9 1 1 10 10 9 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28301.1 - 5.9e-09 35.7 12.9 3.1 8.4 0.0 9.4 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO28301.1 - 3.5e-06 27.1 64.5 0.028 15.0 0.2 13.4 14 2 1 15 15 11 4 Tetratricopeptide repeat DUF2379 PF09543.10 KOO28301.1 - 5.6e-06 26.6 15.2 2.2 8.5 0.0 8.2 8 1 1 9 9 9 1 Protein of unknown function (DUF2379) TPR_19 PF14559.6 KOO28301.1 - 3.4e-05 24.2 36.3 0.12 12.9 3.5 8.0 7 2 2 9 9 8 5 Tetratricopeptide repeat DUF630 PF04783.12 KOO28301.1 - 0.0057 16.8 22.2 8.4 6.7 0.0 8.3 10 0 0 10 10 10 1 Protein of unknown function (DUF630) Sec16_C PF12931.7 KOO28301.1 - 0.24 11.0 6.4 22 4.6 0.0 5.3 3 2 3 7 7 7 0 Sec23-binding domain of Sec16 TPR_20 PF14561.6 KOO28301.1 - 0.91 9.9 9.2 28 5.1 0.4 5.9 3 2 3 6 6 6 0 Tetratricopeptide repeat GP67 PF17634.2 KOO28301.1 - 1.7 9.1 21.6 27 5.3 12.3 5.5 6 0 0 6 6 6 0 Gene product 67 NOA36 PF06524.12 KOO28301.1 - 2.7 7.3 6.7 3.9 6.7 6.7 1.2 1 0 0 1 1 1 0 NOA36 protein Met_synt_B12 PF02965.17 KOO28302.1 - 1.3e-116 388.8 0.0 2.5e-116 387.9 0.0 1.5 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 KOO28302.1 - 5e-74 249.5 0.6 1.1e-73 248.3 0.1 1.9 2 0 0 2 2 2 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 KOO28302.1 - 1.8e-51 175.2 0.0 8.7e-51 172.9 0.0 2.3 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.17 KOO28302.1 - 2e-23 82.6 0.1 2e-23 82.6 0.1 2.4 2 0 0 2 2 1 1 B12 binding domain B12-binding PF02310.19 KOO28302.1 - 1.5e-15 57.3 2.4 3.6e-15 56.1 0.3 2.6 3 0 0 3 3 3 1 B12 binding domain TPR_1 PF00515.28 KOO28302.1 - 6.9e-09 35.2 9.2 0.06 13.2 0.6 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28302.1 - 2.2e-07 30.5 14.4 0.0024 17.9 0.0 5.0 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28302.1 - 8.3e-05 22.7 3.9 0.00026 21.1 3.9 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28302.1 - 0.00072 19.2 3.7 0.28 10.9 0.0 3.6 4 0 0 4 4 4 2 TPR repeat TPR_6 PF13174.6 KOO28302.1 - 0.019 15.5 0.1 0.57 10.9 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28302.1 - 0.054 13.5 1.8 11 6.3 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28302.1 - 0.057 13.6 0.6 41 4.7 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28302.1 - 0.074 13.7 5.7 3 8.6 1.8 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28302.1 - 2.1 9.4 4.3 16 6.7 0.2 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_60s PF00428.19 KOO28302.1 - 4.6 7.9 17.1 0.11 13.1 7.9 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Thioredoxin PF00085.20 KOO28303.1 - 3.5e-08 33.4 0.2 3.9e-08 33.2 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KOO28303.1 - 0.0026 17.2 0.1 0.0028 17.0 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DIM1 PF02966.16 KOO28303.1 - 0.014 15.2 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 TF_Zn_Ribbon PF08271.12 KOO28303.1 - 0.014 14.9 0.6 0.029 13.9 0.6 1.6 1 1 0 1 1 1 0 TFIIB zinc-binding Rpr2 PF04032.16 KOO28303.1 - 0.016 15.5 0.4 0.043 14.1 0.4 1.5 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Thioredoxin_2 PF13098.6 KOO28303.1 - 0.066 13.7 0.5 0.099 13.1 0.5 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_3 PF13192.6 KOO28303.1 - 0.075 13.1 0.2 0.1 12.6 0.2 1.2 1 0 0 1 1 1 0 Thioredoxin domain Cyclin_N PF00134.23 KOO28304.1 - 9.8e-10 38.3 0.1 3.3e-09 36.6 0.1 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.11 KOO28304.1 - 1.6e-08 35.1 0.6 3.3e-08 34.1 0.6 1.7 1 1 0 1 1 1 1 Cyclin SAM_1 PF00536.30 KOO28304.1 - 0.00014 22.2 0.0 0.00024 21.5 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO28304.1 - 0.0013 18.8 0.0 0.0024 18.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ABA_WDS PF02496.16 KOO28305.1 - 0.054 14.0 1.5 0.054 14.0 1.5 2.5 3 1 0 3 3 3 0 ABA/WDS induced protein PIN_8 PF18476.1 KOO28305.1 - 0.17 11.7 1.8 0.83 9.5 1.8 1.9 1 1 0 1 1 1 0 PIN like domain Glyco_trans_1_4 PF13692.6 KOO28306.1 - 6.5e-14 52.5 0.0 1.3e-13 51.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 KOO28306.1 - 1.2e-12 47.7 0.0 2.8e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glycogen_syn PF05693.13 KOO28306.1 - 0.0046 15.6 0.0 0.0065 15.1 0.0 1.1 1 0 0 1 1 1 1 Glycogen synthase Glyco_trans_4_4 PF13579.6 KOO28306.1 - 0.0059 17.1 5.5 0.0059 17.1 5.5 3.6 2 2 2 4 4 4 1 Glycosyl transferase 4-like domain LysM PF01476.20 KOO28307.1 - 0.00016 21.7 0.0 0.02 14.9 0.0 2.5 2 1 0 2 2 2 2 LysM domain Acetyltransf_10 PF13673.7 KOO28307.1 - 0.0018 18.2 0.0 0.0048 16.8 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOO28307.1 - 0.077 13.4 0.0 0.25 11.8 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DinB_2 PF12867.7 KOO28307.1 - 0.28 11.7 0.1 0.28 11.7 0.1 2.2 3 0 0 3 3 3 0 DinB superfamily PDZ_2 PF13180.6 KOO28308.1 - 1.1e-05 25.6 2.3 0.29 11.5 0.0 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KOO28308.1 - 0.00028 20.7 8.3 0.53 10.2 0.1 3.8 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.24 KOO28308.1 - 0.0052 17.1 2.5 9.1 6.7 0.1 3.4 3 0 0 3 3 3 1 PDZ domain PDZ_4 PF17816.1 KOO28308.1 - 0.012 15.9 0.0 5.5 7.4 0.0 3.3 3 0 0 3 3 3 0 PDZ domain DUF4907 PF16250.5 KOO28308.1 - 0.14 12.0 0.1 9.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4907) DUF937 PF06078.11 KOO28309.1 - 0.13 12.8 0.5 0.42 11.2 0.1 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF937) LRR_6 PF13516.6 KOO28310.1 - 3.1e-06 26.8 12.0 43 4.5 0.0 9.1 9 0 0 9 9 9 1 Leucine Rich repeat APH PF01636.23 KOO28310.1 - 7.5e-06 26.0 0.1 5e-05 23.3 0.1 2.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family NACHT PF05729.12 KOO28310.1 - 3.4e-05 23.8 0.0 0.0001 22.3 0.0 1.8 1 0 0 1 1 1 1 NACHT domain TetR_C_24 PF17932.1 KOO28310.1 - 0.26 11.6 1.8 72 3.7 0.1 3.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Topoisom_bac PF01131.20 KOO28311.1 - 9.3e-23 80.9 0.0 6e-22 78.2 0.0 1.9 2 0 0 2 2 2 1 DNA topoisomerase Toprim PF01751.22 KOO28311.1 - 1e-16 61.0 0.0 1.5e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Toprim domain Tub PF01167.18 KOO28313.1 - 1.9e-29 103.1 0.0 1.2e-28 100.5 0.0 1.8 1 1 0 1 1 1 1 Tub family Bromodomain PF00439.25 KOO28314.1 - 2.7e-24 85.0 0.0 5.2e-24 84.1 0.0 1.4 1 0 0 1 1 1 1 Bromodomain BET PF17035.5 KOO28314.1 - 8.1e-13 48.3 0.0 1.9e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DUF2228 PF10228.9 KOO28314.1 - 0.1 12.3 2.2 0.1 12.3 0.4 1.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) AAA_23 PF13476.6 KOO28314.1 - 3.1 8.3 7.2 3.1 8.3 3.1 2.2 2 0 0 2 2 2 0 AAA domain Methyltransf_23 PF13489.6 KOO28315.1 - 1.8e-15 57.2 0.0 2.1e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO28315.1 - 8.8e-15 55.2 0.0 2e-14 54.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO28315.1 - 7e-14 52.2 0.0 1.2e-13 51.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO28315.1 - 2.1e-12 47.7 0.0 5.4e-12 46.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO28315.1 - 4.1e-12 46.2 0.0 4.9e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO28315.1 - 1.3e-05 24.7 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 KOO28315.1 - 2.9e-05 23.7 0.0 5e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 KOO28315.1 - 0.0027 17.7 0.0 0.0042 17.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KOO28315.1 - 0.04 14.0 0.0 0.056 13.6 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_8 PF05148.15 KOO28315.1 - 0.048 13.5 0.0 0.12 12.1 0.0 1.6 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_16 PF10294.9 KOO28315.1 - 0.093 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 KOO28315.1 - 0.11 12.3 0.0 0.14 11.9 0.0 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 KOO28315.1 - 0.11 11.8 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 KOO28315.1 - 0.16 11.9 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Exostosin PF03016.15 KOO28316.1 - 2.4e-12 46.7 0.0 2.9e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Exostosin family SHIPPO-rpt PF07004.12 KOO28317.1 - 4.6e-15 55.7 30.4 0.23 12.4 0.0 10.4 10 0 0 10 10 10 6 Sperm-tail PG-rich repeat ADH_N_assoc PF13823.6 KOO28317.1 - 0.049 13.6 0.0 15 5.6 0.0 2.5 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-associated Sin3_corepress PF08295.12 KOO28317.1 - 0.12 12.5 0.0 20 5.3 0.0 2.3 2 0 0 2 2 2 0 Sin3 family co-repressor Ank_2 PF12796.7 KOO28318.1 - 4.7e-14 52.7 3.9 5.2e-06 27.0 0.4 3.0 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO28318.1 - 3.5e-12 46.2 4.4 0.0028 18.0 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO28318.1 - 1e-10 41.6 6.7 1.6e-05 25.1 0.3 5.1 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO28318.1 - 1.2e-09 38.5 0.4 4.2e-05 24.0 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28318.1 - 2.1e-09 36.8 5.3 0.017 15.6 0.0 5.4 5 0 0 5 5 5 2 Ankyrin repeat NACHT PF05729.12 KOO28318.1 - 2.7e-05 24.1 0.0 0.0002 21.3 0.0 2.6 3 1 0 3 3 3 1 NACHT domain NT5C PF06941.12 KOO28319.1 - 2.2e-15 57.0 0.0 5.4e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Laminin_G_3 PF13385.6 KOO28319.1 - 1.7e-06 28.2 0.0 1.9e-05 24.9 0.0 2.4 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily FAM76 PF16046.5 KOO28319.1 - 0.23 10.8 0.0 0.36 10.2 0.0 1.1 1 0 0 1 1 1 0 FAM76 protein Ank_2 PF12796.7 KOO28321.1 - 8.2e-54 180.2 22.3 9.3e-12 45.4 0.2 6.5 3 1 5 8 8 8 7 Ankyrin repeats (3 copies) Pro_isomerase PF00160.21 KOO28321.1 - 2.3e-37 128.7 0.0 3.9e-37 127.9 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ank_4 PF13637.6 KOO28321.1 - 8.6e-36 121.9 17.9 1.1e-07 32.3 0.1 8.6 6 1 5 11 11 11 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28321.1 - 1.6e-28 95.6 22.8 0.026 15.1 0.0 12.4 12 0 0 12 12 12 8 Ankyrin repeat Ank PF00023.30 KOO28321.1 - 7.8e-28 95.7 40.9 0.00023 21.5 0.6 11.9 12 0 0 12 12 12 9 Ankyrin repeat Ank_5 PF13857.6 KOO28321.1 - 2.8e-26 91.2 21.1 0.00013 22.2 0.3 9.9 3 2 7 10 10 10 8 Ankyrin repeats (many copies) TPR_9 PF13371.6 KOO28321.1 - 7.8e-06 26.0 5.5 8.5e-06 25.8 2.4 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28321.1 - 0.0019 17.9 1.3 0.026 14.3 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28321.1 - 0.0071 16.4 5.2 0.21 11.8 0.3 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat YopE PF03545.13 KOO28321.1 - 0.048 13.8 0.2 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 Yersinia virulence determinant (YopE) TPR_1 PF00515.28 KOO28322.1 - 5.5e-48 158.9 23.8 2.3e-06 27.2 0.1 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28322.1 - 3.6e-40 132.9 25.8 7.8e-05 22.5 1.6 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat STI1 PF17830.1 KOO28322.1 - 3.5e-37 126.1 17.5 1.9e-22 78.9 2.9 3.3 3 0 0 3 3 3 2 STI1 domain TPR_11 PF13414.6 KOO28322.1 - 4.3e-22 77.5 15.5 1.6e-05 24.5 0.0 7.8 7 1 1 8 8 8 4 TPR repeat TPR_12 PF13424.6 KOO28322.1 - 1e-21 77.0 20.8 1.4e-07 31.7 0.1 7.5 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28322.1 - 1.1e-19 70.8 12.0 3e-05 24.6 0.0 6.8 4 2 1 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28322.1 - 7.5e-19 66.3 22.0 0.00034 20.6 0.0 9.1 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28322.1 - 6.2e-16 57.7 13.7 0.083 13.8 0.0 7.7 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28322.1 - 3.1e-12 45.6 11.1 0.26 11.4 0.0 7.6 8 1 1 9 9 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28322.1 - 5.4e-11 42.8 17.0 0.3 11.6 0.4 7.0 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO28322.1 - 2e-09 37.0 11.7 1.5 8.8 0.0 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28322.1 - 6.7e-06 26.2 1.9 0.68 10.1 0.0 4.9 3 2 5 8 8 7 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO28322.1 - 1.3e-05 25.2 0.1 0.022 14.8 0.0 4.5 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 KOO28322.1 - 1.4e-05 25.1 9.9 0.017 15.4 0.2 6.3 8 1 0 8 8 6 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 KOO28322.1 - 6.1e-05 22.4 0.0 7.8 6.0 0.0 4.7 4 0 0 4 4 4 0 SHNi-TPR TPR_6 PF13174.6 KOO28322.1 - 0.00011 22.6 22.4 4.4 8.1 0.1 9.1 9 0 0 9 9 9 1 Tetratricopeptide repeat DUF3856 PF12968.7 KOO28322.1 - 0.0011 19.0 12.3 1.2 9.2 0.2 6.0 4 3 1 5 5 4 2 Domain of Unknown Function (DUF3856) RPN7 PF10602.9 KOO28322.1 - 0.0019 18.0 1.7 0.0019 18.0 1.7 4.2 3 2 0 4 4 3 1 26S proteasome subunit RPN7 BTAD PF03704.17 KOO28322.1 - 0.012 16.0 12.9 3.2 8.2 0.0 4.7 2 2 2 4 4 4 0 Bacterial transcriptional activator domain MIT PF04212.18 KOO28322.1 - 0.04 14.0 25.3 1.1 9.3 0.2 7.0 5 1 2 7 7 7 0 MIT (microtubule interacting and transport) domain TPR_21 PF09976.9 KOO28322.1 - 0.11 12.2 25.3 1.8 8.3 2.1 5.3 3 2 1 4 4 4 0 Tetratricopeptide repeat-like domain Lebercilin PF15619.6 KOO28322.1 - 0.13 11.9 6.5 0.059 13.0 3.5 2.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Fmp27_WPPW PF10359.9 KOO28322.1 - 0.44 9.3 3.0 0.15 10.9 0.2 1.6 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain ANAPC3 PF12895.7 KOO28322.1 - 0.78 10.0 22.6 13 6.1 2.5 6.4 5 2 3 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 NRBF2_MIT PF17169.4 KOO28322.1 - 2.1 8.7 12.4 28 5.0 0.8 5.0 4 1 1 5 5 5 0 MIT domain of nuclear receptor-binding factor 2 CCDC53 PF10152.9 KOO28322.1 - 4.5 7.7 8.4 8.1 6.9 0.2 2.9 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex TIL PF01826.17 KOO28324.1 - 0.0064 16.7 6.0 0.011 15.9 6.0 1.4 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Pkinase PF00069.25 KOO28325.1 - 1.4e-45 155.7 0.0 1e-31 110.3 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28325.1 - 6.9e-19 68.1 0.2 7.9e-18 64.7 0.1 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOO28325.1 - 2.3e-07 30.4 0.2 3.8e-06 26.4 0.0 2.2 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 KOO28325.1 - 0.013 15.4 0.2 0.036 14.0 0.1 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO28325.1 - 0.026 13.9 0.1 0.051 12.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PPR_2 PF13041.6 KOO28327.1 - 5.6e-26 90.5 0.0 1.1e-06 28.7 0.0 5.8 4 2 2 6 6 6 5 PPR repeat family PPR PF01535.20 KOO28327.1 - 2.5e-23 80.7 0.4 0.002 18.2 0.0 9.4 10 0 0 10 10 10 5 PPR repeat PPR_1 PF12854.7 KOO28327.1 - 3.1e-15 55.6 0.3 0.0035 17.0 0.0 6.6 7 0 0 7 7 7 3 PPR repeat PPR_long PF17177.4 KOO28327.1 - 3.7e-13 49.3 1.2 2.3e-05 23.9 0.0 3.8 2 2 2 4 4 4 2 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 KOO28327.1 - 1.3e-12 47.6 0.0 0.00095 19.2 0.0 4.7 4 2 2 6 6 6 3 Pentatricopeptide repeat domain TPR_7 PF13176.6 KOO28327.1 - 0.00065 19.6 0.4 4.4 7.5 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28327.1 - 0.0033 17.9 14.1 9 6.9 0.1 5.8 5 2 1 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28327.1 - 0.004 17.8 34.7 0.4 11.6 0.1 9.3 6 3 4 10 10 10 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28327.1 - 0.0042 17.1 2.5 1.3 9.3 0.0 4.3 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28327.1 - 0.0068 16.7 15.7 0.69 10.2 0.9 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28327.1 - 0.089 13.0 0.0 9.5 6.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28327.1 - 0.29 11.0 2.0 2.5 8.1 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO28327.1 - 2.5 8.1 7.5 16 5.6 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Mito_carr PF00153.27 KOO28328.1 - 1.6e-62 207.4 1.5 1.5e-19 69.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOO28328.1 - 2.5e-05 23.6 0.5 0.003 16.8 0.0 3.2 4 0 0 4 4 4 1 Gammaproteobacterial serine protease Tim17 PF02466.19 KOO28328.1 - 0.87 10.0 10.2 0.74 10.2 2.1 3.1 2 2 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family EutK_C PF16365.5 KOO28328.1 - 4.6 7.4 6.1 29 4.8 0.0 3.6 3 1 1 4 4 4 0 Ethanolamine utilization protein EutK C-terminus DUF3727 PF12527.8 KOO28334.1 - 2.1e-10 40.7 4.7 2.1e-10 40.7 4.7 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3727) AAA_23 PF13476.6 KOO28335.1 - 1.6e-05 25.5 0.6 0.00011 22.8 0.6 2.3 1 1 0 1 1 1 1 AAA domain Ion_trans_2 PF07885.16 KOO28335.1 - 0.00098 19.0 10.4 0.0024 17.8 10.4 1.7 1 1 0 1 1 1 1 Ion channel Metallophos PF00149.28 KOO28335.1 - 0.0043 17.6 0.0 0.0072 16.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO28335.1 - 0.014 15.6 0.0 0.038 14.2 0.0 1.7 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain IRK PF01007.20 KOO28335.1 - 0.41 10.5 8.9 8.7 6.2 8.9 2.2 1 1 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain Ion_trans PF00520.31 KOO28335.1 - 1.3 8.2 11.4 2.2 7.5 11.4 1.2 1 0 0 1 1 1 0 Ion transport protein Ricin_B_lectin PF00652.22 KOO28336.1 - 2.1e-05 24.8 0.0 0.49 10.6 0.0 3.0 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain CDtoxinA PF03498.14 KOO28336.1 - 0.012 15.2 0.0 0.16 11.5 0.0 2.5 3 0 0 3 3 3 0 Cytolethal distending toxin A/C domain SHIPPO-rpt PF07004.12 KOO28337.1 - 0.0022 18.8 4.7 1.2 10.2 3.5 2.5 2 1 0 2 2 2 2 Sperm-tail PG-rich repeat Pkinase PF00069.25 KOO28340.1 - 1.2e-12 47.8 0.0 1.4e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28340.1 - 1e-05 25.0 0.0 1.1e-05 24.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO28341.1 - 1.4e-54 185.2 0.0 1.6e-54 185.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28341.1 - 3.3e-21 75.8 0.0 4.4e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO28341.1 - 0.0033 17.4 0.0 0.0059 16.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO28341.1 - 0.012 14.6 0.0 0.016 14.2 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 KOO28341.1 - 0.05 12.9 0.0 0.084 12.2 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 KOO28341.1 - 0.12 12.0 0.0 0.21 11.1 0.0 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase DUF2475 PF10629.9 KOO28342.1 - 1.3e-12 47.8 10.3 0.02 15.1 0.2 4.5 4 0 0 4 4 4 4 Protein of unknown function (DUF2475) NAGLU PF05089.12 KOO28342.1 - 0.00022 20.3 1.6 0.77 8.7 0.0 4.0 3 1 0 4 4 4 3 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain VGCC_beta4Aa_N PF12052.8 KOO28342.1 - 0.086 13.0 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal PP2C PF00481.21 KOO28343.1 - 2e-20 73.6 0.0 2.5e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO28343.1 - 1.1e-05 25.2 0.2 2.2e-05 24.2 0.2 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO28343.1 - 0.0021 18.0 0.1 0.011 15.7 0.1 1.9 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) SAP PF02037.27 KOO28344.1 - 1.2e-05 25.0 0.9 2.1e-05 24.2 0.9 1.4 1 0 0 1 1 1 1 SAP domain Telomere_Sde2_2 PF13297.6 KOO28344.1 - 0.026 14.1 0.8 0.055 13.1 0.8 1.5 1 0 0 1 1 1 0 Telomere stability C-terminal Methyltransf_23 PF13489.6 KOO28344.1 - 0.083 12.7 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ank_2 PF12796.7 KOO28345.1 - 2.8e-13 50.2 0.1 1.5e-12 47.9 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO28345.1 - 3.9e-12 46.0 0.1 2.2e-07 31.0 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat ADPrib_exo_Tox PF03496.14 KOO28345.1 - 9e-11 41.5 0.0 2.3e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Ank_5 PF13857.6 KOO28345.1 - 3.6e-10 39.9 0.6 2e-07 31.2 0.5 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ART PF01129.18 KOO28345.1 - 9.5e-10 38.1 0.0 2.6e-09 36.7 0.0 1.7 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase Ank_3 PF13606.6 KOO28345.1 - 4.9e-09 35.7 0.2 0.00087 19.6 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 KOO28345.1 - 3.1e-06 27.6 0.4 0.0023 18.5 0.0 3.4 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Transposase_20 PF02371.16 KOO28345.1 - 0.091 13.1 0.1 0.43 10.9 0.0 2.2 2 0 0 2 2 2 0 Transposase IS116/IS110/IS902 family IQ PF00612.27 KOO28345.1 - 2 8.4 4.6 0.9 9.5 0.0 2.9 3 0 0 3 3 3 0 IQ calmodulin-binding motif DUF4476 PF14771.6 KOO28346.1 - 1.4e-17 63.7 0.1 1.9e-08 34.5 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) VWA_3 PF13768.6 KOO28346.1 - 9e-08 32.2 0.2 9e-07 29.0 0.0 2.6 2 2 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 KOO28346.1 - 6.2e-07 30.0 0.2 9.3e-06 26.2 0.0 2.8 2 1 1 3 3 3 1 von Willebrand factor type A domain VWA PF00092.28 KOO28346.1 - 0.0093 16.2 0.0 0.026 14.8 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain Amino_oxidase PF01593.24 KOO28349.1 - 4.1e-56 191.2 0.0 4.6e-56 191.0 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO28349.1 - 2.4e-14 53.3 0.1 5.4e-14 52.2 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO28349.1 - 1.2e-09 37.8 0.1 7.2e-05 22.0 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 KOO28349.1 - 3.3e-07 29.8 0.2 0.00073 18.9 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 KOO28349.1 - 2.2e-05 23.4 0.0 0.011 14.5 0.0 2.2 2 0 0 2 2 2 2 MCRA family DAO PF01266.24 KOO28349.1 - 7.1e-05 22.5 0.7 0.05 13.2 0.1 2.7 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_oxidored PF12831.7 KOO28349.1 - 7.8e-05 22.2 0.0 0.00017 21.1 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOO28349.1 - 0.00013 22.4 0.1 0.019 15.5 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO28349.1 - 0.00037 19.3 0.6 0.0016 17.2 0.6 1.8 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 KOO28349.1 - 0.0018 17.6 0.2 0.0065 15.8 0.1 2.0 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 KOO28349.1 - 0.0023 17.1 0.1 0.0042 16.2 0.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 KOO28349.1 - 0.0073 15.6 0.2 0.033 13.4 0.1 2.0 2 1 0 2 2 2 1 FAD binding domain Rossmann-like PF10727.9 KOO28349.1 - 0.036 13.9 0.2 0.072 13.0 0.2 1.4 1 0 0 1 1 1 0 Rossmann-like domain 3HCDH_N PF02737.18 KOO28349.1 - 0.2 11.5 0.2 0.33 10.8 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PKD_channel PF08016.12 KOO28350.1 - 1.6e-31 109.4 9.4 1.6e-31 109.4 9.4 2.3 2 1 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 KOO28350.1 - 2.3e-15 56.5 16.1 2.3e-15 56.5 16.1 1.6 2 0 0 2 2 2 1 Ion transport protein NAD_binding_10 PF13460.6 KOO28352.1 - 3.2e-13 50.0 0.0 5.1e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO28352.1 - 4.8e-08 32.8 0.0 7.8e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 KOO28352.1 - 1.4e-07 31.2 0.0 2.7e-07 30.3 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO28352.1 - 1.3e-05 24.4 0.0 0.00017 20.7 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 KOO28352.1 - 0.06 12.7 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 KOO28352.1 - 0.065 12.3 0.0 0.79 8.8 0.0 2.2 1 1 0 1 1 1 0 RmlD substrate binding domain NAD_binding_7 PF13241.6 KOO28352.1 - 0.1 13.1 0.2 0.16 12.4 0.2 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding ParcG PF10274.9 KOO28353.1 - 3.4e-83 278.3 0.0 4.3e-83 277.9 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein DUF2475 PF10629.9 KOO28354.1 - 0.00017 21.7 6.2 0.042 14.1 0.5 2.9 3 1 0 3 3 3 2 Protein of unknown function (DUF2475) Pkinase PF00069.25 KOO28355.1 - 8.3e-41 140.1 0.0 9.3e-41 139.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28355.1 - 2.1e-25 89.5 0.0 2.6e-25 89.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO28355.1 - 0.00011 21.6 0.1 0.00036 19.9 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO28355.1 - 0.0093 15.9 2.0 1.2 9.0 0.7 2.0 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO28355.1 - 0.028 13.4 0.0 0.035 13.1 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 KOO28355.1 - 0.15 10.8 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SBBP PF06739.11 KOO28356.1 - 0.0002 21.3 8.0 0.72 9.9 0.5 4.0 4 0 0 4 4 4 3 Beta-propeller repeat HMG_box PF00505.19 KOO28357.1 - 9.3e-14 51.6 10.6 1.1e-07 32.2 2.2 2.7 2 0 0 2 2 2 2 HMG (high mobility group) box FHA PF00498.26 KOO28357.1 - 1.2e-13 51.2 0.0 3e-13 49.9 0.0 1.7 2 0 0 2 2 2 1 FHA domain APH PF01636.23 KOO28357.1 - 2.7e-08 34.1 0.3 4e-08 33.5 0.3 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family HMG_box_2 PF09011.10 KOO28357.1 - 1.3e-05 25.7 12.2 0.0042 17.7 2.4 2.5 1 1 1 2 2 2 2 HMG-box domain EcKinase PF02958.20 KOO28357.1 - 2.1e-05 24.0 0.0 3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Yop-YscD_cpl PF16697.5 KOO28357.1 - 6.7e-05 23.1 0.0 0.00018 21.8 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF1679 PF07914.11 KOO28357.1 - 0.013 14.4 0.0 0.02 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Pollen_allerg_1 PF01357.21 KOO28357.1 - 0.24 11.4 1.6 20 5.3 0.2 2.3 2 0 0 2 2 2 0 Pollen allergen HMG_box_5 PF14887.6 KOO28357.1 - 0.43 10.6 10.7 1.7 8.6 1.9 2.5 1 1 1 2 2 2 0 HMG (high mobility group) box 5 Apolipoprotein PF01442.18 KOO28358.1 - 0.028 14.3 12.2 0.038 13.9 12.2 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF1940 PF09155.10 KOO28358.1 - 0.035 14.2 0.2 0.048 13.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1940) Bap31_Bap29_C PF18035.1 KOO28358.1 - 0.13 12.3 1.9 0.24 11.4 1.9 1.6 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain MCU PF04678.13 KOO28358.1 - 0.18 11.9 1.2 0.23 11.6 1.2 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter HSCB_C PF07743.13 KOO28358.1 - 1.6 9.3 9.2 12 6.5 9.2 2.1 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain Nucleotid_trans PF03407.16 KOO28359.1 - 3.7e-05 23.8 0.0 5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Cupin_8 PF13621.6 KOO28360.1 - 3.6e-18 66.2 0.0 4.5e-16 59.3 0.0 2.5 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 KOO28360.1 - 2.4e-16 60.2 0.0 1.6e-15 57.5 0.0 2.1 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 KOO28360.1 - 9.7e-06 25.3 0.0 1.3e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein MAPEG PF01124.18 KOO28361.1 - 3.8e-17 62.4 1.6 9.4e-17 61.1 1.6 1.7 1 0 0 1 1 1 1 MAPEG family Methyltransf_23 PF13489.6 KOO28361.1 - 7.4e-07 29.1 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO28361.1 - 0.00021 22.0 0.0 0.00051 20.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO28361.1 - 0.00047 20.7 0.0 0.00098 19.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO28361.1 - 0.0034 17.2 0.0 0.0068 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_1 PF00036.32 KOO28362.1 - 2.9e-22 76.5 1.2 8e-05 21.9 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO28362.1 - 2.2e-19 69.6 7.0 2.4e-09 37.5 0.5 2.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO28362.1 - 9.2e-19 66.0 1.4 0.001 18.5 0.0 4.6 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 KOO28362.1 - 1.2e-16 59.2 2.2 0.0068 16.3 0.0 4.7 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 KOO28362.1 - 7.3e-16 57.8 12.8 0.00021 21.1 0.3 4.3 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 KOO28362.1 - 8.5e-10 38.5 5.9 0.004 17.1 0.1 4.0 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO28362.1 - 0.014 15.7 0.1 5.6 7.4 0.0 3.5 2 1 1 4 4 4 0 EF-hand domain nec1 PF10379.9 KOO28362.1 - 0.015 14.8 0.1 4.8 6.6 0.0 2.2 1 1 0 2 2 2 0 Virulence protein nec1 EF-hand_10 PF14788.6 KOO28362.1 - 0.019 14.8 1.7 9.2 6.2 0.0 3.4 4 0 0 4 4 4 0 EF hand Gastrin PF00918.17 KOO28362.1 - 0.066 14.2 2.5 8.6 7.4 0.2 2.3 2 0 0 2 2 2 0 Gastrin/cholecystokinin family Agenet PF05641.12 KOO28363.1 - 2e-15 57.0 8.2 1.6e-07 31.7 0.4 4.5 3 1 1 4 4 4 4 Agenet domain PP2C PF00481.21 KOO28364.1 - 3.1e-26 92.6 0.0 4.4e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO28364.1 - 1.2e-08 35.1 0.4 3.5e-07 30.3 0.4 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KOO28364.1 - 0.0018 17.9 0.8 0.004 16.8 0.8 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C EF-hand_7 PF13499.6 KOO28365.1 - 6.8e-09 36.1 1.4 9.5e-06 26.0 0.5 1.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO28365.1 - 4.2e-08 32.3 1.0 8e-05 22.0 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO28365.1 - 1.6e-07 30.4 0.1 0.0014 18.0 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO28365.1 - 3.4e-07 29.7 0.2 0.0026 17.6 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO28365.1 - 3.4e-05 23.6 0.0 0.0055 16.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair T3RM_EcoP15I_C PF18273.1 KOO28365.1 - 0.05 13.9 0.0 0.065 13.6 0.0 1.2 1 0 0 1 1 1 0 Type III R-M EcoP15I C-terminal domain Syja_N PF02383.18 KOO28366.1 - 1e-44 153.2 0.0 1.7e-44 152.4 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 KOO28366.1 - 4.8e-11 42.6 0.0 1.1e-10 41.5 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Lipase_GDSL_2 PF13472.6 KOO28367.1 - 5e-09 36.8 0.0 1.5e-08 35.3 0.0 1.8 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family ALGX PF16822.5 KOO28367.1 - 1.5e-06 28.1 1.1 1.5e-06 28.1 1.1 2.4 2 0 0 2 2 2 1 SGNH hydrolase-like domain, acetyltransferase AlgX AntA PF08346.12 KOO28367.1 - 0.023 15.2 0.6 0.092 13.3 0.6 2.0 1 0 0 1 1 1 0 AntA/AntB antirepressor UFD1 PF03152.14 KOO28368.1 - 1.5e-15 57.1 0.0 1.8e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 TPR_2 PF07719.17 KOO28369.1 - 9.7e-19 65.9 17.0 0.00044 20.2 0.9 7.9 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28369.1 - 5.3e-14 51.6 3.5 2.1e-06 27.3 1.2 6.1 3 2 3 6 6 6 2 TPR repeat TPR_1 PF00515.28 KOO28369.1 - 9.5e-14 50.5 2.2 0.0002 21.0 0.1 6.7 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28369.1 - 3.6e-13 49.9 43.2 1.3e-06 28.9 7.8 5.3 4 2 1 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28369.1 - 1.4e-10 40.6 0.7 0.011 15.9 0.1 6.2 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28369.1 - 4.4e-09 36.7 18.5 0.00016 22.1 1.9 6.1 4 2 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28369.1 - 9e-09 35.4 34.4 0.00022 21.8 1.2 7.4 3 2 4 7 7 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28369.1 - 1e-08 35.3 25.5 3.3e-06 27.3 1.8 5.1 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 KOO28369.1 - 3.7e-06 27.2 3.3 4.2 8.2 0.1 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28369.1 - 9.2e-06 25.7 30.1 8.3e-05 22.7 3.3 5.5 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28369.1 - 1.2e-05 24.9 7.3 0.0015 18.4 0.1 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28369.1 - 0.00013 22.1 3.4 0.055 13.9 0.1 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO28369.1 - 0.00022 21.4 6.7 0.043 14.0 0.2 3.9 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 KOO28369.1 - 0.02 15.4 27.4 1.2 10.0 0.9 6.9 6 0 0 6 6 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO28369.1 - 0.032 14.3 2.6 1.2 9.2 0.6 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat DUF627 PF04781.12 KOO28369.1 - 0.17 11.9 2.3 1.2 9.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF627) BTAD PF03704.17 KOO28369.1 - 0.28 11.6 22.1 0.14 12.5 10.2 3.2 2 1 0 2 2 2 0 Bacterial transcriptional activator domain TPPK_C PF12555.8 KOO28369.1 - 0.52 10.4 4.9 1.2 9.2 4.9 1.6 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal TPR_10 PF13374.6 KOO28369.1 - 3.1 7.8 20.3 0.15 12.0 0.9 6.4 7 1 1 8 8 8 0 Tetratricopeptide repeat PDZ PF00595.24 KOO28370.1 - 4.5e-08 33.3 0.0 6.8e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO28370.1 - 4e-05 23.4 0.0 5.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO28370.1 - 0.00072 19.8 0.1 0.001 19.4 0.1 1.3 1 0 0 1 1 1 1 PDZ domain FctA PF12892.7 KOO28370.1 - 0.0048 17.7 0.8 0.024 15.4 0.8 1.8 1 1 0 1 1 1 1 Spy0128-like isopeptide containing domain AA_permease_2 PF13520.6 KOO28371.1 - 8.3e-06 24.9 10.1 9.3e-06 24.7 10.1 1.0 1 0 0 1 1 1 1 Amino acid permease SHIPPO-rpt PF07004.12 KOO28372.1 - 0.037 15.0 14.4 0.14 13.1 2.0 3.8 3 0 0 3 3 3 0 Sperm-tail PG-rich repeat EarP PF10093.9 KOO28372.1 - 0.16 11.1 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP Spc7 PF08317.11 KOO28373.1 - 0.015 14.2 0.3 0.021 13.7 0.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4164 PF13747.6 KOO28373.1 - 0.019 15.2 0.8 0.039 14.2 0.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Atg14 PF10186.9 KOO28373.1 - 0.22 10.6 0.8 0.25 10.4 0.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 THOC7 PF05615.13 KOO28373.1 - 0.29 11.4 4.5 0.7 10.2 4.2 1.8 1 1 0 1 1 1 0 Tho complex subunit 7 DUF4200 PF13863.6 KOO28373.1 - 0.63 10.4 5.2 0.62 10.5 2.5 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) SelR PF01641.18 KOO28374.1 - 0.00019 21.5 0.0 0.00066 19.8 0.0 1.9 2 0 0 2 2 2 1 SelR domain CIA30 PF08547.12 KOO28374.1 - 0.00029 20.9 0.0 0.00049 20.1 0.0 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Peptidase_C69 PF03577.15 KOO28375.1 - 2.1e-52 178.4 0.0 1.3e-51 175.8 0.0 1.9 1 1 0 1 1 1 1 Peptidase family C69 ABC1 PF03109.16 KOO28376.1 - 1.5e-26 92.9 0.0 2.6e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO28376.1 - 1.3e-05 25.3 0.4 1.3e-05 25.3 0.4 2.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO28376.1 - 0.0077 15.6 0.0 0.7 9.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain DUF658 PF04936.12 KOO28377.1 - 0.055 13.2 0.2 0.064 13.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF658) CDH1_2_SANT_HL1 PF18375.1 KOO28377.1 - 0.064 13.9 1.0 0.11 13.2 1.0 1.4 1 0 0 1 1 1 0 CDH1/2 SANT-Helical linker 1 Na_H_Exchanger PF00999.21 KOO28378.1 - 0.14 11.0 16.4 0.043 12.6 8.4 2.5 2 2 1 3 3 3 0 Sodium/hydrogen exchanger family Gtr1_RagA PF04670.12 KOO28379.1 - 5.4e-68 228.8 1.4 6.6e-68 228.5 1.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KOO28379.1 - 2.9e-06 26.8 0.0 4.8e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KOO28379.1 - 4.3e-05 23.7 0.0 7.7e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO28379.1 - 0.0001 21.8 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOO28379.1 - 0.00011 21.9 0.3 0.00014 21.4 0.3 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOO28379.1 - 0.00033 20.7 0.0 0.0006 19.9 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KOO28379.1 - 0.0017 18.8 0.1 0.01 16.2 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain Ras PF00071.22 KOO28379.1 - 0.012 15.3 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 Ras family DUF815 PF05673.13 KOO28379.1 - 0.022 13.9 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_14 PF13173.6 KOO28379.1 - 0.036 14.1 0.0 0.083 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Chorein_N PF12624.7 KOO28380.1 - 5.6e-27 94.2 0.1 1.2e-26 93.1 0.1 1.5 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 KOO28380.1 - 1.1e-26 94.1 0.0 1.5e-26 93.7 0.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal DUF1289 PF06945.13 KOO28380.1 - 0.56 10.1 2.0 0.58 10.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) VPS13_C PF16909.5 KOO28381.1 - 9.3e-32 110.2 0.3 7.5e-28 97.5 0.0 2.5 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 KOO28381.1 - 1.6e-29 103.1 0.0 3e-15 56.3 0.0 3.5 3 0 0 3 3 3 3 SHR-binding domain of vacuolar-sorting associated protein 13 GRAM PF02893.20 KOO28381.1 - 1.4e-08 34.6 0.0 0.0045 16.9 0.0 2.5 2 0 0 2 2 2 2 GRAM domain ATG_C PF09333.11 KOO28381.1 - 3.7e-08 33.6 0.0 1.4e-07 31.7 0.0 2.1 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Vps36_ESCRT-II PF11605.8 KOO28381.1 - 0.032 14.4 0.1 0.9 9.8 0.0 3.0 3 0 0 3 3 3 0 Vacuolar protein sorting protein 36 Vps36 RCC1_2 PF13540.6 KOO28383.1 - 8.6e-12 44.5 0.2 2.1e-05 24.2 0.1 2.4 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 KOO28383.1 - 1.2e-09 38.7 0.4 4.2e-07 30.5 0.4 2.8 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat PAF-AH_p_II PF03403.13 KOO28384.1 - 1e-09 37.4 0.0 4e-05 22.3 0.0 2.7 1 1 1 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_3 PF07859.13 KOO28384.1 - 0.001 19.0 0.1 0.0018 18.2 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 KOO28384.1 - 0.014 15.1 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOO28384.1 - 0.044 14.4 7.7 0.16 12.6 7.2 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family SNARE PF05739.19 KOO28386.1 - 3.7e-12 46.1 0.1 1.2e-11 44.4 0.1 2.0 1 0 0 1 1 1 1 SNARE domain DUF4731 PF15875.5 KOO28386.1 - 0.011 15.9 0.0 0.034 14.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4731) Aldo_ket_red PF00248.21 KOO28388.1 - 9.6e-43 146.4 0.0 1.3e-42 146.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Cupin_8 PF13621.6 KOO28388.1 - 8.1e-32 110.9 0.0 1.4e-31 110.1 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO28388.1 - 7.3e-06 25.7 0.0 2.9e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 KOO28388.1 - 0.011 16.2 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase HECT PF00632.25 KOO28390.1 - 1.9e-52 178.7 0.0 2.2e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Hormone_recep PF00104.30 KOO28391.1 - 0.07 12.7 2.0 0.85 9.1 0.4 2.4 2 0 0 2 2 2 0 Ligand-binding domain of nuclear hormone receptor DUF3638 PF12340.8 KOO28392.1 - 2.8e-17 62.8 0.1 4.9e-16 58.7 0.1 2.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO28392.1 - 1.4e-13 50.0 0.0 3.3e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) DUF5601 PF18151.1 KOO28392.1 - 0.11 12.9 0.3 0.33 11.3 0.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) GPS PF01825.21 KOO28394.1 - 4.1e-08 33.6 6.9 9.2e-08 32.5 6.9 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif BON PF04972.17 KOO28394.1 - 0.84 10.0 3.2 3.1 8.2 0.4 2.5 2 0 0 2 2 2 0 BON domain Peptidase_S26 PF10502.9 KOO28395.1 - 4.3e-15 55.7 0.0 6.4e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 KOO28395.1 - 3.4e-11 42.9 0.0 2e-10 40.5 0.0 2.1 1 1 0 1 1 1 1 Peptidase S24-like RRM_1 PF00076.22 KOO28396.1 - 3.9e-31 106.7 0.1 9.2e-15 54.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOO28396.1 - 2e-07 31.0 0.1 0.0056 16.8 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif PUNUT PF16913.5 KOO28397.1 - 0.035 13.3 9.0 0.05 12.8 9.0 1.2 1 0 0 1 1 1 0 Purine nucleobase transmembrane transport EamA PF00892.20 KOO28397.1 - 0.058 13.6 9.6 0.12 12.5 9.6 1.6 1 1 0 1 1 1 0 EamA-like transporter family TPT PF03151.16 KOO28397.1 - 0.074 12.4 6.0 0.13 11.6 6.0 1.4 1 1 0 1 1 1 0 Triose-phosphate Transporter family Phage_holin_3_6 PF07332.11 KOO28397.1 - 0.11 12.5 0.3 0.11 12.5 0.3 2.3 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Spc7 PF08317.11 KOO28398.1 - 1.8 7.4 69.7 0.16 10.8 19.8 4.1 1 1 3 4 4 4 0 Spc7 kinetochore protein 2-oxoacid_dh PF00198.23 KOO28399.1 - 9.1e-64 215.1 0.2 1.4e-63 214.5 0.2 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.17 KOO28399.1 - 1.5e-30 105.3 0.5 9.4e-15 54.7 0.1 2.8 2 0 0 2 2 2 2 e3 binding domain Biotin_lipoyl PF00364.22 KOO28399.1 - 8.3e-19 67.2 2.0 2.9e-18 65.5 1.1 2.4 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KOO28399.1 - 0.039 13.8 0.1 0.16 11.8 0.0 2.2 2 0 0 2 2 2 0 Biotin-lipoyl like FA_desaturase PF00487.24 KOO28400.1 - 1.4e-17 64.4 21.0 8.3e-11 42.2 10.8 2.5 1 1 1 2 2 2 2 Fatty acid desaturase Sun2_CC2 PF18580.1 KOO28401.1 - 0.0082 16.4 1.0 0.0082 16.4 1.0 3.3 3 0 0 3 3 3 1 SUN2 coiled coil domain 2 DUF4795 PF16043.5 KOO28401.1 - 0.1 12.2 16.6 0.012 15.2 4.6 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4795) ABC_tran_CTD PF16326.5 KOO28401.1 - 1.1 9.5 30.1 0.058 13.7 1.6 4.7 4 1 2 6 6 6 0 ABC transporter C-terminal domain Tup_N PF08581.10 KOO28401.1 - 8 6.8 8.0 1.2 9.5 1.2 3.0 4 0 0 4 4 4 0 Tup N-terminal Prefoldin_2 PF01920.20 KOO28401.1 - 8.6 6.4 14.8 2.3 8.2 0.1 4.5 5 0 0 5 5 5 0 Prefoldin subunit Sulfotransfer_2 PF03567.14 KOO28402.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.3 1 1 0 1 1 1 0 Sulfotransferase family TPR_2 PF07719.17 KOO28403.1 - 2.1e-12 46.1 0.7 0.0012 18.8 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28403.1 - 1.1e-11 44.9 1.5 7.7e-09 35.7 0.7 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28403.1 - 6.3e-11 41.6 0.2 0.023 14.5 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO28403.1 - 2.1e-07 30.6 2.8 0.0012 18.6 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28403.1 - 3.4e-07 30.3 4.6 0.0013 18.8 0.6 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28403.1 - 1.1e-05 25.0 1.7 0.13 12.0 0.6 3.9 3 1 0 3 3 3 2 TPR repeat TPR_6 PF13174.6 KOO28403.1 - 1.3e-05 25.5 4.7 1.4 9.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_4 PF07721.14 KOO28403.1 - 8.2e-05 22.9 3.0 0.21 12.3 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28403.1 - 0.00015 22.2 3.1 0.00028 21.3 1.2 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28403.1 - 0.0002 21.3 0.0 1 9.8 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28403.1 - 0.00025 21.6 11.2 0.0033 18.0 3.7 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28403.1 - 0.00033 20.5 1.3 1.5 9.0 0.2 3.7 2 1 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 KOO28403.1 - 0.0052 16.9 1.8 0.011 15.7 0.6 1.9 1 1 1 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_17 PF13431.6 KOO28403.1 - 0.02 15.2 0.6 4 8.0 0.1 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28403.1 - 0.026 15.3 5.9 7.8 7.6 1.4 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 KOO28403.1 - 0.055 13.9 5.9 1.9 8.9 0.4 2.8 1 1 2 3 3 3 0 Bacterial transcriptional activator domain DEAD PF00270.29 KOO28404.1 - 9.5e-37 126.4 0.1 1.7e-36 125.6 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO28404.1 - 6.9e-30 103.7 0.3 1.1e-27 96.5 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO28404.1 - 3.3e-07 30.4 0.0 6.7e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 KOO28404.1 - 0.00043 19.7 0.2 0.0014 18.0 0.0 1.9 1 1 1 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Transcrip_reg PF01709.20 KOO28404.1 - 0.033 13.6 1.9 0.13 11.7 1.9 1.9 1 1 0 1 1 1 0 Transcriptional regulator ChaC PF04752.12 KOO28404.1 - 0.13 12.3 0.0 0.43 10.6 0.0 1.7 1 1 0 1 1 1 0 ChaC-like protein Methyltransf_25 PF13649.6 KOO28405.1 - 4.9e-15 56.0 0.3 1.7e-13 51.1 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO28405.1 - 1.1e-14 54.8 0.0 5.6e-14 52.6 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO28405.1 - 1.4e-07 31.5 0.0 2.2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO28405.1 - 1.6e-07 31.9 0.0 7e-07 29.9 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO28405.1 - 4.3e-05 23.4 0.0 0.00042 20.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO28405.1 - 6.5e-05 22.4 0.0 0.00024 20.5 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 KOO28405.1 - 0.0046 16.4 0.0 0.0067 15.8 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 KOO28405.1 - 0.0079 16.2 0.0 0.059 13.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_24 PF13578.6 KOO28405.1 - 0.012 16.7 0.1 0.041 14.9 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 KOO28405.1 - 0.013 15.1 0.0 0.053 13.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_9 PF08003.11 KOO28405.1 - 0.11 11.4 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_2 PF00891.18 KOO28405.1 - 0.16 11.2 0.0 3.4 6.9 0.0 2.1 1 1 1 2 2 2 0 O-methyltransferase domain Methyltransf_33 PF10017.9 KOO28405.1 - 0.16 11.1 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Arm PF00514.23 KOO28406.1 - 1.4e-15 56.7 9.1 8.2e-05 22.5 0.1 6.9 5 2 1 6 6 6 5 Armadillo/beta-catenin-like repeat Cas_Csy4 PF09618.10 KOO28406.1 - 3.4 7.8 7.6 2.4 8.3 2.8 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) Rhodanese PF00581.20 KOO28407.1 - 1.1e-05 25.9 0.0 2.2e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain KASH_CCD PF14662.6 KOO28408.1 - 3e-05 23.9 13.0 4e-05 23.5 13.0 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DDE_Tnp_IS66 PF03050.14 KOO28408.1 - 0.43 10.0 8.7 4.1 6.8 5.9 2.1 2 0 0 2 2 2 0 Transposase IS66 family DUF4407 PF14362.6 KOO28408.1 - 2.4 7.4 6.8 2.9 7.1 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tho2 PF11262.8 KOO28408.1 - 4.8 6.3 10.3 6.9 5.8 10.3 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Spc7 PF08317.11 KOO28408.1 - 9.4 5.0 18.0 12 4.7 18.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein ORC4_C PF14629.6 KOO28409.1 - 1.7e-15 57.0 0.0 2.6e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 KOO28409.1 - 1e-08 35.8 2.6 1.7e-08 35.1 0.2 2.4 2 2 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 KOO28409.1 - 0.0083 16.5 0.0 0.14 12.6 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOO28409.1 - 0.16 12.2 0.0 0.6 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Ank_2 PF12796.7 KOO28410.1 - 2.3e-19 69.8 0.0 3e-12 46.9 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO28410.1 - 4.8e-15 55.7 2.9 8.7e-06 26.2 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO28410.1 - 3e-12 46.4 0.2 0.00015 22.0 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO28410.1 - 6e-09 35.4 0.1 0.002 18.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KOO28410.1 - 6.5e-09 35.9 0.2 0.00025 21.3 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ribosomal_L6 PF00347.23 KOO28411.1 - 6.3e-08 33.2 0.2 0.042 14.5 0.0 3.2 3 0 0 3 3 3 2 Ribosomal protein L6 TRAM_LAG1_CLN8 PF03798.16 KOO28412.1 - 1.2e-13 51.3 4.9 1.4e-13 51.1 4.9 1.0 1 0 0 1 1 1 1 TLC domain BDV_M PF16520.5 KOO28412.1 - 0.044 14.1 0.0 0.088 13.2 0.0 1.5 1 0 0 1 1 1 0 ssRNA-binding matrix protein of Bornaviridae PNP_UDP_1 PF01048.20 KOO28413.1 - 1.1e-19 70.6 6.5 2.1e-19 69.7 6.5 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily Acetyltransf_1 PF00583.25 KOO28415.1 - 0.009 16.2 0.3 0.04 14.2 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family SET PF00856.28 KOO28415.1 - 0.017 15.5 0.0 0.29 11.5 0.0 2.6 2 1 0 2 2 2 0 SET domain FAP PF07174.11 KOO28416.1 - 2.4 7.6 28.6 5 6.5 26.1 2.0 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) KLRAQ PF10205.9 KOO28417.1 - 0.0081 16.4 9.5 0.11 12.8 0.1 3.3 3 2 1 4 4 4 2 Predicted coiled-coil domain-containing protein JAKMIP_CC3 PF16034.5 KOO28417.1 - 4.2 7.3 16.4 47 3.8 0.3 3.2 2 1 0 2 2 2 0 JAKMIP CC3 domain Exo_endo_phos PF03372.23 KOO28418.1 - 1.5e-08 34.5 0.4 7.7e-05 22.3 0.1 2.1 1 1 1 2 2 2 2 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.16 KOO28419.1 - 1e-38 133.2 36.6 2.1e-23 82.8 15.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 KOO28419.1 - 1.6e-08 33.4 21.1 1.8e-06 26.6 9.1 2.3 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_2 PF13347.6 KOO28419.1 - 3.3e-05 22.7 6.4 3.3e-05 22.7 6.4 2.3 1 1 0 2 2 2 1 MFS/sugar transport protein OATP PF03137.20 KOO28419.1 - 0.00011 20.6 12.2 0.0099 14.2 0.5 3.2 2 1 1 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 KOO28419.1 - 0.01 14.7 27.0 0.017 14.0 11.8 2.5 2 1 0 2 2 2 0 Sugar (and other) transporter LacY_symp PF01306.19 KOO28419.1 - 0.024 13.4 3.5 0.33 9.7 0.1 2.4 2 0 0 2 2 2 0 LacY proton/sugar symporter MFS_1_like PF12832.7 KOO28419.1 - 0.51 9.1 16.4 0.43 9.4 8.0 2.5 2 1 1 3 3 3 0 MFS_1 like family ENTH PF01417.20 KOO28420.1 - 8.3e-59 197.1 0.0 1.3e-38 131.9 0.0 2.2 2 0 0 2 2 2 2 ENTH domain ANTH PF07651.16 KOO28420.1 - 2.4e-08 33.3 0.0 0.0029 16.6 0.0 2.2 2 0 0 2 2 2 2 ANTH domain UbiA PF01040.18 KOO28421.1 - 6e-50 169.9 14.2 7.9e-50 169.5 14.2 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family SET PF00856.28 KOO28423.1 - 4.8e-22 79.1 3.2 1.3e-21 77.8 0.1 3.0 2 2 0 2 2 2 1 SET domain Pre-SET PF05033.16 KOO28423.1 - 4.2e-07 30.6 0.0 2.2e-06 28.3 0.0 2.3 2 0 0 2 2 2 1 Pre-SET motif DUF4200 PF13863.6 KOO28423.1 - 3.3 8.1 9.4 3.1 8.2 5.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) LRR_6 PF13516.6 KOO28424.1 - 1.2e-07 31.2 11.4 0.0099 15.9 0.1 4.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 KOO28424.1 - 0.018 15.5 0.2 6.7 7.3 0.0 3.1 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO28424.1 - 0.25 12.0 1.7 57 4.8 0.0 3.7 3 1 0 3 3 3 0 Leucine Rich Repeat YbfN PF13982.6 KOO28425.1 - 0.049 13.9 1.1 0.18 12.1 0.2 2.2 1 1 1 2 2 2 0 YbfN-like lipoprotein APG6_N PF17675.1 KOO28425.1 - 0.17 12.4 7.1 3.5 8.2 0.4 2.3 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF3450 PF11932.8 KOO28425.1 - 0.24 10.7 7.0 2.6 7.3 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) CorA PF01544.18 KOO28425.1 - 0.28 10.5 2.2 0.33 10.2 2.2 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Spc7 PF08317.11 KOO28425.1 - 0.42 9.4 9.3 1.8 7.3 9.3 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 KOO28425.1 - 1.3 9.1 9.6 5.5 7.1 3.9 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein EF-hand_1 PF00036.32 KOO28426.1 - 2.1e-09 36.2 4.1 0.13 11.8 0.2 4.7 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO28426.1 - 1.6e-07 31.6 0.2 0.68 10.4 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO28426.1 - 1.1e-06 27.8 12.5 0.055 13.0 0.4 4.5 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO28426.1 - 1.1e-05 25.1 1.5 0.74 9.7 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO28426.1 - 1.6e-05 24.5 4.0 1.9 8.7 0.2 4.6 4 0 0 4 4 4 2 EF-hand domain DUF1848 PF08902.11 KOO28426.1 - 0.1 12.3 3.1 0.64 9.7 3.1 2.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) NDUFB10 PF10249.9 KOO28426.1 - 3.3 8.2 7.6 0.94 10.0 3.3 2.4 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase subunit 10 PRK PF00485.18 KOO28427.1 - 1.5e-39 135.8 0.0 2.1e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 KOO28427.1 - 1e-07 32.5 0.0 1.8e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KOO28427.1 - 4.4e-06 26.1 0.1 1.8e-05 24.1 0.0 2.0 2 1 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 KOO28427.1 - 3.2e-05 24.1 0.1 6.6e-05 23.1 0.0 1.5 2 0 0 2 2 1 1 AAA domain AAA_26 PF13500.6 KOO28427.1 - 0.00016 21.6 0.0 0.00028 20.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOO28427.1 - 0.00028 21.3 0.2 0.12 12.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain MobB PF03205.14 KOO28427.1 - 0.00074 19.4 0.1 0.0018 18.2 0.1 1.7 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.27 KOO28427.1 - 0.00097 19.7 0.0 0.0024 18.4 0.1 1.5 1 1 0 1 1 1 1 ABC transporter CbiA PF01656.23 KOO28427.1 - 0.0027 17.8 0.0 0.0065 16.5 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Cytidylate_kin PF02224.18 KOO28427.1 - 0.0038 17.0 0.0 1.3 8.7 0.0 2.2 2 0 0 2 2 2 1 Cytidylate kinase IstB_IS21 PF01695.17 KOO28427.1 - 0.0042 16.8 0.0 0.0066 16.2 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein CoaE PF01121.20 KOO28427.1 - 0.0044 16.7 1.4 0.1 12.3 0.4 2.2 2 0 0 2 2 2 1 Dephospho-CoA kinase APS_kinase PF01583.20 KOO28427.1 - 0.0045 16.9 0.0 0.012 15.5 0.0 1.7 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_16 PF13191.6 KOO28427.1 - 0.0054 17.1 0.0 0.014 15.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 KOO28427.1 - 0.0061 17.1 0.0 0.0091 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOO28427.1 - 0.01 16.1 0.0 0.024 14.9 0.0 1.7 2 0 0 2 2 1 0 AAA domain T2SSE PF00437.20 KOO28427.1 - 0.011 14.9 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NB-ARC PF00931.22 KOO28427.1 - 0.015 14.5 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain SRP54 PF00448.22 KOO28427.1 - 0.015 14.9 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Thymidylate_kin PF02223.17 KOO28427.1 - 0.015 15.0 0.2 0.07 12.8 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase MeaB PF03308.16 KOO28427.1 - 0.029 13.4 0.0 0.06 12.3 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 KOO28427.1 - 0.029 13.8 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_28 PF13521.6 KOO28427.1 - 0.031 14.5 0.0 0.057 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KOO28427.1 - 0.048 14.1 0.0 0.08 13.3 0.0 1.3 1 0 0 1 1 1 0 RNA helicase DUF87 PF01935.17 KOO28427.1 - 0.068 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 KOO28427.1 - 0.072 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.15 KOO28427.1 - 0.081 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 KOO28427.1 - 0.091 12.5 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KOO28427.1 - 0.13 12.2 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea CobA_CobO_BtuR PF02572.15 KOO28427.1 - 0.15 12.3 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP AAA PF00004.29 KOO28427.1 - 0.15 12.5 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOO28427.1 - 0.18 11.7 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Ank_2 PF12796.7 KOO28428.1 - 2.4e-18 66.5 0.0 5.4e-11 42.9 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO28428.1 - 4.3e-18 63.5 0.0 0.00023 21.4 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 KOO28428.1 - 1e-16 60.5 0.7 2.3e-05 24.6 0.1 4.9 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 KOO28428.1 - 1.7e-16 60.1 1.3 1.4e-08 34.8 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO28428.1 - 1e-12 48.3 0.1 5.7e-06 26.8 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) SHIPPO-rpt PF07004.12 KOO28431.1 - 0.051 14.5 1.5 11 7.1 0.9 3.0 2 1 0 2 2 2 0 Sperm-tail PG-rich repeat TC1 PF15063.6 KOO28432.1 - 0.027 14.4 0.3 0.095 12.6 0.3 1.9 1 0 0 1 1 1 0 Thyroid cancer protein 1 MlaE PF02405.16 KOO28434.1 - 2.1e-24 86.4 7.8 2.1e-24 86.4 7.8 1.9 2 0 0 2 2 2 1 Permease MlaE AAA_21 PF13304.6 KOO28434.1 - 0.00044 20.1 0.1 0.00074 19.4 0.1 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 KOO28434.1 - 0.012 15.8 0.0 0.099 12.9 0.0 2.5 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit Phage_integrase PF00589.22 KOO28437.1 - 0.0083 15.9 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_5 PF13102.6 KOO28437.1 - 0.017 15.5 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 Phage integrase SAM-like domain Abhydrolase_6 PF12697.7 KOO28440.1 - 0.00011 22.9 1.8 0.00014 22.5 1.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family SpoIIE PF07228.12 KOO28441.1 - 6.5e-12 45.8 0.0 9.8e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KOO28441.1 - 0.00012 21.8 0.1 0.00021 21.0 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C EF-hand_7 PF13499.6 KOO28442.1 - 4.8e-19 68.6 0.0 1.7e-08 34.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO28442.1 - 3.5e-18 63.9 0.3 0.00052 19.7 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO28442.1 - 3.5e-16 57.5 0.1 0.00089 18.6 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO28442.1 - 2.7e-10 39.2 0.1 0.0038 16.7 0.0 4.5 4 0 0 4 4 4 2 EF hand GPS PF01825.21 KOO28442.1 - 2.6e-08 34.3 4.3 5.7e-08 33.2 4.3 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EF-hand_8 PF13833.6 KOO28442.1 - 0.0012 18.7 0.1 0.23 11.3 0.0 2.9 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO28442.1 - 0.0041 17.4 0.0 4.9 7.5 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO28442.1 - 0.13 12.6 0.0 11 6.4 0.0 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region HMG14_17 PF01101.18 KOO28442.1 - 0.15 13.0 3.9 0.33 12.0 3.9 1.5 1 0 0 1 1 1 0 HMG14 and HMG17 HEPN_LA2681 PF18733.1 KOO28442.1 - 0.16 11.2 0.0 8.8 5.6 0.0 2.2 1 1 1 2 2 2 0 LA2681-like HEPN Fibin PF15819.5 KOO28443.1 - 4.1 7.1 17.1 1.6 8.5 11.2 2.9 1 1 1 2 2 2 0 Fin bud initiation factor homologue Hexapep_loop PF18776.1 KOO28444.1 - 0.079 12.6 0.3 0.17 11.5 0.3 1.5 1 0 0 1 1 1 0 Hexapeptide repeat including loop RCC1 PF00415.18 KOO28445.1 - 1e-20 74.0 3.5 2.6e-06 28.0 0.3 4.8 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.7 KOO28445.1 - 9.4e-07 29.3 0.1 2.9e-06 27.8 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO28445.1 - 3.2e-06 27.6 0.1 0.042 14.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) RCC1_2 PF13540.6 KOO28445.1 - 1.3e-05 24.9 25.2 0.0095 15.7 1.5 4.6 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Ank PF00023.30 KOO28445.1 - 0.00014 22.2 1.2 0.005 17.2 0.2 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 KOO28445.1 - 0.00022 21.4 0.3 0.00022 21.4 0.3 2.7 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28445.1 - 0.0034 17.8 2.5 0.026 15.1 0.2 3.2 3 0 0 3 3 3 1 Ankyrin repeat DUF4490 PF14892.6 KOO28446.1 - 0.0053 16.8 0.0 0.0093 16.0 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4490) FA_desaturase PF00487.24 KOO28448.1 - 9e-11 42.1 21.4 9e-11 42.1 21.4 1.5 1 1 0 1 1 1 1 Fatty acid desaturase TGT PF01702.18 KOO28449.1 - 8.6e-15 54.7 0.0 3.2e-10 39.7 0.0 2.5 1 1 2 3 3 3 2 Queuine tRNA-ribosyltransferase WHEP-TRS PF00458.20 KOO28449.1 - 0.00095 19.3 0.1 0.0016 18.5 0.1 1.4 1 0 0 1 1 1 1 WHEP-TRS domain Exostosin PF03016.15 KOO28450.1 - 3.5e-06 26.5 0.0 5.6e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Exostosin family Fer2_3 PF13085.6 KOO28451.1 - 1.2e-31 108.9 0.0 2.1e-31 108.2 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 KOO28451.1 - 8.4e-08 32.6 5.4 8.4e-08 32.6 5.4 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 KOO28451.1 - 4.3e-07 30.3 7.5 4.3e-07 30.3 7.5 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 KOO28451.1 - 1.9e-06 27.9 3.1 1.9e-06 27.9 3.1 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 KOO28451.1 - 0.004 17.1 1.1 0.004 17.1 1.1 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 KOO28451.1 - 0.098 13.3 15.2 0.067 13.8 8.1 3.0 2 2 1 3 3 3 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 KOO28451.1 - 1.3 9.3 13.1 0.74 10.0 8.8 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain FemAB_like PF04339.12 KOO28452.1 - 2.6e-42 145.3 0.0 1.6e-21 76.9 0.0 2.0 1 1 1 2 2 2 2 Peptidogalycan biosysnthesis/recognition Acetyltransf_6 PF13480.7 KOO28452.1 - 0.0015 18.7 0.1 0.0025 18.0 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF2959 PF11172.8 KOO28453.1 - 0.067 13.3 7.3 0.12 12.5 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) BRF1 PF07741.13 KOO28453.1 - 4.4 7.7 0.0 4.4 7.7 0.0 3.2 3 1 1 4 4 4 0 Brf1-like TBP-binding domain PHD PF00628.29 KOO28454.1 - 1.7e-10 40.6 6.7 3.1e-10 39.8 6.7 1.4 1 0 0 1 1 1 1 PHD-finger WHIM1 PF15612.6 KOO28454.1 - 0.00044 19.7 0.0 0.00099 18.6 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 FYVE_2 PF02318.16 KOO28454.1 - 1.5 9.0 5.6 3.2 8.0 0.5 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger Heliorhodopsin PF18761.1 KOO28456.1 - 4.2e-35 121.2 8.1 5.1e-35 120.9 8.1 1.1 1 0 0 1 1 1 1 Heliorhodopsin SPT_ssu-like PF11779.8 KOO28456.1 - 1.1 8.9 5.4 13 5.5 5.4 2.8 1 1 0 1 1 1 0 Small subunit of serine palmitoyltransferase-like LRR_6 PF13516.6 KOO28457.1 - 3.9e-17 60.8 21.1 0.047 13.7 0.2 8.0 8 0 0 8 8 8 6 Leucine Rich repeat LRR_1 PF00560.33 KOO28457.1 - 0.0064 16.9 0.0 24 6.0 0.0 5.1 6 0 0 6 6 6 1 Leucine Rich Repeat Lipase_GDSL_2 PF13472.6 KOO28457.1 - 0.027 14.8 1.3 0.17 12.2 0.0 2.6 3 1 0 3 3 3 0 GDSL-like Lipase/Acylhydrolase family TP_methylase PF00590.20 KOO28458.1 - 7.1e-27 94.7 1.6 7.1e-27 94.7 1.6 1.7 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases LpxC PF03331.13 KOO28458.1 - 0.063 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 UDP-3-O-acyl N-acetylglycosamine deacetylase Chloroa_b-bind PF00504.21 KOO28459.1 - 1.8e-34 119.6 0.0 2.7e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Ion_trans PF00520.31 KOO28460.1 - 9.4e-24 84.0 12.0 1.4e-23 83.4 12.0 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO28460.1 - 6.5e-12 45.2 6.8 6.5e-12 45.2 6.8 2.1 2 1 0 2 2 2 1 Ion channel cNMP_binding PF00027.29 KOO28460.1 - 1.5e-09 37.8 0.0 2.9e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Glucan_synthase PF02364.15 KOO28461.1 - 2.5e-117 393.1 1.8 2.6e-99 333.5 1.7 2.9 1 1 1 2 2 2 2 1,3-beta-glucan synthase component Thioredoxin PF00085.20 KOO28463.1 - 3.8e-16 58.9 0.0 8.1e-16 57.9 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 KOO28463.1 - 0.00057 19.8 0.0 0.0019 18.2 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like domain DUF3456 PF11938.8 KOO28463.1 - 0.021 15.3 0.1 0.044 14.3 0.1 1.6 1 0 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP DTW PF03942.15 KOO28463.1 - 0.099 12.3 0.1 0.23 11.2 0.0 1.6 2 0 0 2 2 2 0 DTW domain Mobilization_B PF17511.2 KOO28465.1 - 0.07 13.5 0.1 0.43 11.0 0.0 2.2 2 0 0 2 2 2 0 Mobilization protein B Glyco_tranf_2_3 PF13641.6 KOO28466.1 - 2.1e-19 70.3 0.0 2.8e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 KOO28466.1 - 7.9e-19 68.4 1.5 1.5e-18 67.5 1.5 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 KOO28466.1 - 3.9e-11 42.7 0.0 6.5e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KOO28466.1 - 7.3e-05 22.6 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Peptidase_U4 PF03419.13 KOO28466.1 - 4.1 6.6 8.2 9 5.5 0.0 2.3 2 0 0 2 2 2 0 Sporulation factor SpoIIGA Ribosomal_L35Ae PF01247.18 KOO28467.1 - 8.1e-43 144.5 0.6 1.4e-42 143.7 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L35Ae Sel1 PF08238.12 KOO28468.1 - 0.00012 22.6 0.2 0.00094 19.8 0.0 2.6 2 0 0 2 2 2 1 Sel1 repeat Aldo_ket_red PF00248.21 KOO28469.1 - 8.6e-44 149.9 0.0 8.5e-35 120.4 0.0 2.1 1 1 1 2 2 2 2 Aldo/keto reductase family Cupin_8 PF13621.6 KOO28470.1 - 3.5e-09 36.8 0.0 0.013 15.3 0.0 3.2 3 0 0 3 3 3 3 Cupin-like domain Cupin_4 PF08007.12 KOO28470.1 - 0.1 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein FAP206 PF12018.8 KOO28471.1 - 3e-19 69.6 0.9 5.2e-19 68.8 0.9 1.4 1 0 0 1 1 1 1 Domain of unknown function YlqD PF11068.8 KOO28471.1 - 1.8 8.9 5.3 1.2 9.5 0.5 2.6 3 1 1 4 4 4 0 YlqD protein Malic_M PF03949.15 KOO28472.1 - 3.6e-83 278.8 0.1 4.6e-83 278.4 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 KOO28472.1 - 1.2e-66 224.0 0.0 2.5e-66 222.9 0.0 1.6 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain Pyr_redox_2 PF07992.14 KOO28472.1 - 0.001 18.4 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF1846 PF08903.11 KOO28473.1 - 0.27 9.7 0.0 0.39 9.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) EXS PF03124.14 KOO28474.1 - 2e-65 221.3 19.6 2.5e-65 221.0 19.6 1.1 1 0 0 1 1 1 1 EXS family ARL2_Bind_BART PF11527.8 KOO28475.1 - 1.1e-07 32.0 0.0 1.7e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART NYN PF01936.18 KOO28475.1 - 8.6e-06 26.3 0.0 1.9e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 NYN domain CSD PF00313.22 KOO28475.1 - 0.005 16.7 0.0 0.0091 15.8 0.0 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain Angiomotin_C PF12240.8 KOO28475.1 - 3 7.4 5.7 0.5 9.9 0.1 2.4 3 0 0 3 3 3 0 Angiomotin C terminal Cro PF09048.10 KOO28476.1 - 0.2 11.7 3.7 0.17 11.9 1.7 1.9 1 1 1 2 2 2 0 Cro HC2 PF07382.11 KOO28477.1 - 0.0048 17.0 14.7 0.0073 16.4 14.7 1.2 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Staphylcoagulse PF04022.12 KOO28477.1 - 0.12 11.9 0.6 0.12 11.9 0.6 2.1 2 0 0 2 2 2 0 Staphylocoagulase repeat Laminin_G_3 PF13385.6 KOO28477.1 - 0.16 12.1 0.1 0.29 11.3 0.1 1.5 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily DASH_Dad4 PF08650.10 KOO28478.1 - 0.23 11.4 2.7 2.6 8.1 0.1 3.6 3 0 0 3 3 3 0 DASH complex subunit Dad4 Surfac_D-trimer PF09006.11 KOO28478.1 - 9.8 6.2 6.6 5 7.1 0.2 3.4 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation Inhibitor_I29 PF08246.12 KOO28479.1 - 0.12 12.9 3.4 0.23 11.9 0.1 2.9 2 1 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) EF-hand_1 PF00036.32 KOO28480.1 - 1.1e-19 68.4 8.7 0.00047 19.5 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO28480.1 - 1.4e-18 67.1 20.0 4.3e-06 27.1 2.7 3.7 1 1 4 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.6 KOO28480.1 - 1.1e-17 62.3 4.1 0.0033 17.2 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO28480.1 - 9.9e-12 43.8 9.5 0.00092 18.6 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO28480.1 - 3.5e-11 42.8 5.6 3.5e-05 23.5 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair BD_b_sandwich PF18820.1 KOO28480.1 - 0.001 19.1 1.1 0.14 12.2 0.1 3.1 1 1 2 3 3 3 1 Bdellovibrio Beta-sandwich EF-hand_10 PF14788.6 KOO28480.1 - 0.0058 16.5 0.4 17 5.4 0.0 4.2 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.9 KOO28480.1 - 0.1 12.9 3.7 1.2 9.5 0.2 3.2 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO28480.1 - 1.5 8.8 3.8 2.7 8.0 1.5 2.5 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand TRAPPC9-Trs120 PF08626.11 KOO28481.1 - 1.6e-13 49.0 0.0 1.2e-05 23.0 0.1 2.7 2 1 0 2 2 2 2 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TRAPPC-Trs85 PF12739.7 KOO28481.1 - 0.11 11.4 4.2 0.19 10.7 4.2 1.4 1 1 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Poxvirus_B22R_N PF13169.6 KOO28482.1 - 0.065 13.7 0.2 0.065 13.7 0.2 2.4 2 2 1 4 4 4 0 Poxvirus B22R protein N-terminal FtsK_alpha PF17854.1 KOO28483.1 - 0.33 11.1 2.3 0.38 10.9 0.2 2.1 2 1 0 2 2 2 0 FtsK alpha domain TPR_MLP1_2 PF07926.12 KOO28483.1 - 0.55 10.3 26.7 1.6 8.8 10.0 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein CENP-K PF11802.8 KOO28483.1 - 1.8 8.1 14.5 1 8.9 3.8 2.1 2 0 0 2 2 2 0 Centromere-associated protein K FUSC PF04632.12 KOO28483.1 - 2.7 6.4 19.8 3.2 6.2 19.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Fez1 PF06818.15 KOO28483.1 - 3.7 8.0 26.9 1.5e+02 2.7 26.9 2.0 1 1 0 1 1 1 0 Fez1 DUF4337 PF14235.6 KOO28483.1 - 4.9 7.3 17.2 4.9 7.2 7.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Lectin_N PF03954.14 KOO28483.1 - 5.1 6.8 8.9 1.7 8.4 1.0 2.6 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain DUF1664 PF07889.12 KOO28483.1 - 6.8 6.7 7.8 9.6 6.3 2.2 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) AAA PF00004.29 KOO28484.1 - 9.6e-19 68.1 0.0 2.5e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IQ PF00612.27 KOO28484.1 - 0.00096 18.7 0.9 0.0023 17.6 0.9 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_5 PF07728.14 KOO28484.1 - 0.061 13.3 0.0 0.21 11.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Casc1 PF12366.8 KOO28484.1 - 4.7 6.7 9.2 1.5 8.3 3.4 2.4 1 1 0 2 2 2 0 Cancer susceptibility candidate 1 MADF_DNA_bdg PF10545.9 KOO28484.1 - 7.4 7.0 9.0 0.57 10.5 0.9 3.0 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF2828 PF11443.8 KOO28486.1 - 3.5e-06 25.4 1.0 5.8e-06 24.7 1.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) LUC7 PF03194.15 KOO28486.1 - 0.091 12.4 1.1 0.18 11.5 1.1 1.4 1 0 0 1 1 1 0 LUC7 N_terminus Motile_Sperm PF00635.26 KOO28487.1 - 6e-18 64.7 0.5 1.1e-17 63.9 0.5 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain TPR_2 PF07719.17 KOO28487.1 - 7.4e-07 28.8 3.6 0.0069 16.4 0.3 5.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TTC5_OB PF16669.5 KOO28487.1 - 1e-06 28.4 0.0 6.8e-06 25.8 0.0 2.3 1 1 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain TPR_16 PF13432.6 KOO28487.1 - 8.8e-06 26.3 1.0 8.8e-06 26.3 1.0 4.6 2 2 2 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28487.1 - 4e-05 23.8 11.8 0.02 15.2 3.2 3.9 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28487.1 - 9.6e-05 22.0 3.3 0.0038 17.0 0.1 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28487.1 - 0.00072 19.2 0.0 0.13 11.9 0.0 3.9 3 1 1 4 4 4 1 TPR repeat ASH PF15780.5 KOO28487.1 - 0.0012 19.1 0.1 0.0024 18.0 0.1 1.5 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TPR_19 PF14559.6 KOO28487.1 - 0.008 16.7 0.3 0.008 16.7 0.3 4.1 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28487.1 - 0.56 11.2 29.0 0.59 11.1 1.0 6.9 2 2 5 7 7 7 0 Tetratricopeptide repeat EF-hand_6 PF13405.6 KOO28488.1 - 2.8e-41 135.9 18.6 3.2e-07 29.7 0.3 6.8 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.32 KOO28488.1 - 2.9e-40 132.8 17.8 5.9e-08 31.7 0.3 6.4 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.6 KOO28488.1 - 2.8e-34 115.1 25.7 1.2e-06 27.8 0.7 6.5 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO28488.1 - 3.2e-30 104.4 19.5 4.8e-10 39.8 0.3 4.7 4 1 2 6 6 6 5 EF-hand domain pair EF-hand_8 PF13833.6 KOO28488.1 - 1.4e-23 82.5 16.3 1.7e-07 31.0 0.2 6.3 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_9 PF14658.6 KOO28488.1 - 0.0001 22.5 0.0 1.4 9.3 0.0 4.6 4 0 0 4 4 4 1 EF-hand domain p25-alpha PF05517.12 KOO28488.1 - 0.00017 21.8 0.0 0.37 11.0 0.0 3.9 2 1 1 4 4 4 1 p25-alpha SPARC_Ca_bdg PF10591.9 KOO28488.1 - 0.0052 17.1 0.8 26 5.2 0.0 4.6 4 2 1 5 5 5 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO28488.1 - 0.0075 17.1 0.0 22 6.0 0.0 3.4 3 0 0 3 3 3 0 EF-hand domain DUF3584 PF12128.8 KOO28488.1 - 0.035 11.6 11.2 0.21 9.1 13.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) EF-hand_4 PF12763.7 KOO28488.1 - 0.097 12.6 2.0 11 6.0 0.1 3.3 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 KOO28488.1 - 0.2 11.6 0.6 36 4.2 0.0 4.0 3 3 2 5 5 5 0 Caleosin related protein RACo_linker PF17650.1 KOO28488.1 - 0.25 11.2 5.0 0.37 10.7 3.1 2.2 2 0 0 2 2 2 0 RACo linker region EF-hand_14 PF17959.1 KOO28488.1 - 0.64 10.4 8.8 35 4.8 0.0 5.6 6 0 0 6 6 6 0 EF-hand domain Fez1 PF06818.15 KOO28488.1 - 1 9.8 14.2 2.2 8.7 14.2 1.6 1 0 0 1 1 1 0 Fez1 SAM_1 PF00536.30 KOO28489.1 - 0.0001 22.7 0.2 0.00026 21.3 0.2 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO28489.1 - 0.0012 18.9 0.1 0.0038 17.3 0.1 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KOO28489.1 - 0.064 13.2 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain LpxB PF02684.15 KOO28489.1 - 0.48 9.2 5.4 0.085 11.7 0.2 2.3 2 0 0 2 2 2 0 Lipid-A-disaccharide synthetase Dermcidin PF15291.6 KOO28489.1 - 1.3 9.6 7.4 11 6.7 0.2 3.6 3 0 0 3 3 3 0 Dermcidin, antibiotic peptide DUF1664 PF07889.12 KOO28489.1 - 3.8 7.6 11.5 2.3 8.3 1.4 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Radical_SAM PF04055.21 KOO28490.1 - 3e-30 105.8 0.0 7.8e-30 104.4 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily UPF0004 PF00919.20 KOO28490.1 - 1.2e-22 79.7 0.0 5e-22 77.8 0.0 2.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 KOO28490.1 - 3.5e-10 39.7 0.0 7.1e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 TRAM domain Rotamase_3 PF13616.6 KOO28490.1 - 3.8e-09 37.1 0.0 1.3e-08 35.4 0.0 1.9 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase PF00639.21 KOO28490.1 - 1.5e-07 32.3 0.0 3.9e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 KOO28490.1 - 0.0017 19.2 0.0 0.0085 16.9 0.0 2.0 2 0 0 2 2 2 1 PPIC-type PPIASE domain TRAM_2 PF18693.1 KOO28490.1 - 0.0044 17.2 0.0 0.012 15.8 0.0 1.8 1 0 0 1 1 1 1 TRAM domain Ribosomal_L10 PF00466.20 KOO28491.1 - 1.4e-13 50.8 0.0 2e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 DUF2809 PF10990.8 KOO28491.1 - 0.088 13.5 0.0 0.17 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2809) Semialdhyde_dhC PF02774.18 KOO28491.1 - 0.2 11.7 0.9 0.45 10.6 0.1 1.9 2 1 1 3 3 3 0 Semialdehyde dehydrogenase, dimerisation domain Ion_trans PF00520.31 KOO28493.1 - 4.5e-07 29.3 1.3 7.3e-07 28.7 1.3 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO28493.1 - 0.17 11.9 5.3 0.39 10.7 5.2 1.7 1 1 0 1 1 1 0 Ion channel Yip1 PF04893.17 KOO28493.1 - 4.1 7.1 9.8 12 5.5 9.8 1.7 1 1 0 1 1 1 0 Yip1 domain Sulfatase PF00884.23 KOO28494.1 - 3.7e-22 79.1 0.1 9.3e-22 77.8 0.1 1.6 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 KOO28494.1 - 6.9e-05 22.6 0.1 0.0061 16.2 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase UCH PF00443.29 KOO28495.1 - 1e-20 74.3 0.3 2.3e-20 73.2 0.1 1.4 1 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 KOO28495.1 - 6.6e-13 49.1 0.2 7.8e-12 45.7 0.0 2.6 2 0 0 2 2 2 1 DUSP domain DUF4795 PF16043.5 KOO28495.1 - 0.001 18.7 0.3 0.0018 17.9 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) UCH_1 PF13423.6 KOO28495.1 - 0.02 14.5 0.2 0.03 13.9 0.0 1.4 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase DUF1682 PF07946.14 KOO28495.1 - 1.9 7.6 3.6 0.35 10.1 0.2 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) ShK PF01549.24 KOO28497.1 - 3.5e-15 56.3 21.0 1.2e-07 32.1 8.9 2.4 2 0 0 2 2 2 2 ShK domain-like zf-CCCH PF00642.24 KOO28497.1 - 0.37 10.8 3.6 6.1 6.9 0.0 3.4 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ion_trans PF00520.31 KOO28498.1 - 6e-15 55.1 5.4 9e-15 54.6 5.4 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO28498.1 - 0.34 10.9 4.7 0.87 9.6 4.7 1.8 1 1 0 1 1 1 0 Ion channel Polysacc_deac_1 PF01522.21 KOO28500.1 - 8e-16 58.1 0.0 1.2e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase 2OG-FeII_Oxy_3 PF13640.6 KOO28500.1 - 0.0007 20.4 0.2 0.0014 19.5 0.2 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fer2_4 PF13510.6 KOO28500.1 - 0.01 15.9 0.1 0.021 14.9 0.1 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Ras PF00071.22 KOO28501.1 - 1.7e-14 53.8 0.1 1.4e-11 44.2 0.0 2.1 1 1 1 2 2 2 2 Ras family AAA_16 PF13191.6 KOO28501.1 - 0.032 14.6 0.1 0.15 12.4 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 KOO28501.1 - 0.033 14.4 0.0 0.32 11.2 0.0 2.1 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 KOO28501.1 - 0.049 13.5 0.0 3.2 7.6 0.0 2.1 1 1 1 2 2 2 0 RsgA GTPase adh_short PF00106.25 KOO28502.1 - 9.5e-24 83.9 0.1 1.7e-18 66.8 0.2 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO28502.1 - 5.7e-16 58.8 0.1 4.6e-14 52.5 0.1 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO28502.1 - 5.4e-06 26.4 0.2 8.2e-06 25.9 0.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOO28502.1 - 1.1e-05 25.1 0.0 1.5e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 KOO28502.1 - 0.05 13.6 0.9 0.55 10.2 0.9 2.2 1 1 0 1 1 1 0 Zinc-binding dehydrogenase PH_12 PF16457.5 KOO28504.1 - 0.03 14.8 0.0 0.065 13.8 0.0 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain Phage_P2_GpU PF06995.11 KOO28504.1 - 0.32 10.6 1.8 20 4.8 0.0 2.9 2 1 0 2 2 2 0 Phage P2 GpU TolA_bind_tri PF16331.5 KOO28505.1 - 0.0001 22.3 18.8 0.0031 17.6 0.4 3.7 3 1 1 4 4 4 3 TolA binding protein trimerisation Atg14 PF10186.9 KOO28505.1 - 0.33 10.0 15.8 1.3 8.1 15.8 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_TATA_bd PF12325.8 KOO28505.1 - 0.34 11.1 19.4 2.6 8.3 8.1 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4140 PF13600.6 KOO28505.1 - 0.67 10.4 20.2 0.067 13.6 1.1 3.3 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) HALZ PF02183.18 KOO28505.1 - 0.76 10.0 4.5 18 5.7 0.0 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper FapA PF03961.13 KOO28505.1 - 0.96 8.0 6.8 0.34 9.5 2.2 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A FliE PF02049.18 KOO28505.1 - 0.99 9.6 6.8 0.36 11.0 3.1 2.2 2 1 0 2 2 2 0 Flagellar hook-basal body complex protein FliE FH2 PF02181.23 KOO28505.1 - 1.5 7.9 8.9 0.45 9.6 2.1 2.1 1 1 1 2 2 2 0 Formin Homology 2 Domain Prominin PF05478.11 KOO28505.1 - 1.9 6.3 5.5 5.1 4.9 0.6 2.0 1 1 0 2 2 2 0 Prominin OmpH PF03938.14 KOO28505.1 - 4.7 7.5 20.6 15 6.0 13.3 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) YabA PF06156.13 KOO28505.1 - 5.4 7.7 10.5 9.6 6.9 1.0 3.1 2 1 0 3 3 3 0 Initiation control protein YabA CLZ PF16526.5 KOO28505.1 - 7.7 7.0 14.5 3.9 7.9 0.4 3.4 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ZapB PF06005.12 KOO28505.1 - 8.8 6.9 25.8 0.13 12.7 4.0 3.8 3 1 0 3 3 3 0 Cell division protein ZapB Nuc_sug_transp PF04142.15 KOO28506.1 - 3.1e-26 92.3 6.3 3.9e-26 92.0 6.3 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO28506.1 - 0.00014 22.0 4.6 0.00014 22.0 4.6 2.7 3 0 0 3 3 3 1 EamA-like transporter family CRT-like PF08627.10 KOO28506.1 - 0.00016 20.8 1.7 0.00022 20.3 1.7 1.2 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 KOO28506.1 - 0.0012 18.1 2.2 0.0012 18.1 2.2 1.8 2 0 0 2 2 2 1 UAA transporter family PUNUT PF16913.5 KOO28506.1 - 0.0079 15.5 4.8 0.015 14.6 4.5 1.6 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport Phage_holin_5_1 PF06946.11 KOO28506.1 - 0.95 9.9 4.4 1.9 8.9 0.3 2.9 2 1 0 3 3 3 0 Bacteriophage A118-like holin, Hol118 ATP-sulfurylase PF01747.17 KOO28507.1 - 7.4e-65 218.4 0.0 1.1e-64 217.8 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 KOO28507.1 - 3.3e-39 134.1 0.0 4.5e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 PUA-like domain 2OG-FeII_Oxy_3 PF13640.6 KOO28508.1 - 0.019 15.8 0.1 0.033 15.1 0.1 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF2968 PF11180.8 KOO28509.1 - 0.053 13.1 10.5 0.061 13.0 10.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF2475 PF10629.9 KOO28510.1 - 0.2 11.9 5.8 6.6 7.0 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2475) DUF2475 PF10629.9 KOO28511.1 - 0.06 13.6 4.1 1.5 9.0 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2475) Aquarius_N PF16399.5 KOO28512.1 - 1e-191 639.0 0.0 6.4e-188 626.5 0.0 2.9 1 1 1 2 2 2 2 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 KOO28512.1 - 2.4e-27 96.4 0.0 1.4e-26 93.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 KOO28512.1 - 5e-25 88.3 0.0 1.3e-24 86.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOO28512.1 - 2.9e-08 33.7 0.0 0.00059 19.6 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 KOO28512.1 - 1.1e-07 32.3 0.1 1.4e-06 28.7 0.1 2.4 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 KOO28512.1 - 0.0056 16.2 0.0 0.0096 15.5 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Parvo_NS1 PF01057.17 KOO28512.1 - 0.0066 15.6 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 PhoH PF02562.16 KOO28512.1 - 0.014 14.9 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.15 KOO28512.1 - 0.021 14.8 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA PF00004.29 KOO28512.1 - 0.026 15.0 0.0 0.055 13.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 KOO28512.1 - 0.04 13.1 0.3 0.13 11.4 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 KOO28512.1 - 0.08 13.2 0.0 0.56 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain PDZ PF00595.24 KOO28513.1 - 7.7e-08 32.6 0.0 1.2e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO28513.1 - 3.1e-05 23.7 0.0 5.9e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain LRR_4 PF12799.7 KOO28514.1 - 1.2e-08 35.1 1.3 0.0013 19.1 0.1 2.2 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO28514.1 - 7.7e-07 28.8 6.8 0.0002 21.0 1.3 2.1 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 KOO28514.1 - 0.0016 18.7 3.3 0.54 11.0 0.1 3.6 3 1 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.6 KOO28514.1 - 1.2 9.4 3.3 25 5.2 0.0 3.1 3 0 0 3 3 3 0 Leucine Rich repeat DUF4379 PF14311.6 KOO28515.1 - 0.05 14.0 1.6 0.11 12.9 0.0 2.2 2 0 0 2 2 2 0 Probable Zinc-ribbon domain THF_DHG_CYH_C PF02882.19 KOO28517.1 - 1e-66 223.2 3.4 1e-66 223.2 3.4 1.7 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 KOO28517.1 - 9.5e-41 138.7 0.3 1.5e-40 138.0 0.3 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 KOO28517.1 - 0.025 13.5 0.4 0.047 12.6 0.4 1.4 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 KOO28517.1 - 0.13 12.3 0.6 2.1 8.4 0.1 2.8 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Gal_Lectin PF02140.18 KOO28518.1 - 1.5e-14 54.2 1.0 3.6e-14 53.0 1.0 1.7 1 0 0 1 1 1 1 Galactose binding lectin domain Thioredox_DsbH PF03190.15 KOO28518.1 - 0.087 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Beta-lactamase PF00144.24 KOO28519.1 - 2.1e-25 89.7 1.6 2.9e-25 89.2 1.6 1.1 1 0 0 1 1 1 1 Beta-lactamase HGWP PF03578.15 KOO28519.1 - 0.13 11.8 0.4 0.29 10.7 0.4 1.6 1 0 0 1 1 1 0 HGWP repeat PUB PF09409.10 KOO28520.1 - 3.5e-15 55.7 0.0 6.2e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 PUB domain DUF2379 PF09543.10 KOO28520.1 - 0.018 15.2 0.4 0.048 13.9 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2379) DnaJ PF00226.31 KOO28522.1 - 1.2e-20 73.4 0.1 3.2e-20 72.0 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain FHA PF00498.26 KOO28523.1 - 7.5e-13 48.6 0.0 1.5e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain Drf_FH3 PF06367.16 KOO28523.1 - 0.028 14.0 1.1 0.067 12.8 1.1 1.6 1 0 0 1 1 1 0 Diaphanous FH3 Domain Glyco_hydr_116N PF12215.8 KOO28524.1 - 6.4e-16 58.7 0.0 1e-08 35.1 0.0 2.5 2 0 0 2 2 2 2 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term DUF608 PF04685.13 KOO28524.1 - 4.2e-11 42.6 0.1 6.7e-11 42.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region PAN_4 PF14295.6 KOO28524.1 - 0.014 15.3 3.2 0.035 14.0 3.2 1.6 1 0 0 1 1 1 0 PAN domain PAN_2 PF08276.11 KOO28524.1 - 0.21 11.8 1.5 0.45 10.7 1.5 1.5 1 0 0 1 1 1 0 PAN-like domain Sacchrp_dh_NADP PF03435.18 KOO28525.1 - 1.3e-30 106.4 0.0 2.3e-30 105.5 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Sacchrp_dh_C PF16653.5 KOO28525.1 - 1.1e-25 91.3 0.0 1.6e-25 90.7 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain LicD PF04991.13 KOO28526.1 - 0.00011 22.5 0.0 0.00025 21.2 0.0 1.6 2 0 0 2 2 2 1 LicD family DUF1295 PF06966.12 KOO28527.1 - 9.3e-45 153.0 3.2 9.3e-45 153.0 3.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) DUF2781 PF10914.8 KOO28527.1 - 6.9e-21 75.2 10.2 6.9e-21 75.2 10.2 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2781) ICMT PF04140.14 KOO28527.1 - 0.005 17.2 0.1 0.023 15.1 0.1 2.2 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family NTP_transferase PF00483.23 KOO28528.1 - 1.7e-10 40.9 0.0 3e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 KOO28528.1 - 7.4e-06 25.5 6.3 0.0033 17.1 3.9 3.1 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 KOO28528.1 - 0.00013 20.3 3.3 0.00019 19.8 3.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 KOO28528.1 - 0.12 11.3 0.9 0.17 10.8 0.9 1.2 1 0 0 1 1 1 0 L-fucokinase DUF4185 PF13810.6 KOO28529.1 - 4.1e-13 49.3 0.1 5.5e-13 48.8 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) AP_endonuc_2 PF01261.24 KOO28530.1 - 0.022 14.2 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Rgp1 PF08737.10 KOO28532.1 - 0.016 14.4 0.0 0.016 14.4 0.0 1.1 1 0 0 1 1 1 0 Rgp1 Cyclin PF08613.11 KOO28533.1 - 3e-20 73.2 0.1 4.8e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 Cyclin Homeodomain PF00046.29 KOO28533.1 - 1.5e-16 60.0 0.7 2.8e-16 59.1 0.7 1.5 1 0 0 1 1 1 1 Homeodomain Cyclin_N PF00134.23 KOO28533.1 - 3.9e-06 26.6 0.1 6.2e-06 26.0 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Homeobox_KN PF05920.11 KOO28533.1 - 0.0099 15.8 0.3 0.028 14.3 0.3 1.8 1 0 0 1 1 1 1 Homeobox KN domain RraB PF06877.11 KOO28534.1 - 0.11 13.3 0.0 0.46 11.2 0.0 2.0 2 0 0 2 2 2 0 Regulator of ribonuclease activity B TRAM_LAG1_CLN8 PF03798.16 KOO28535.1 - 4.8e-20 72.1 12.0 4.8e-20 72.1 12.0 1.4 2 0 0 2 2 2 1 TLC domain Phage_holin_3_6 PF07332.11 KOO28535.1 - 0.041 13.9 1.8 0.37 10.8 0.1 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III TPR_2 PF07719.17 KOO28536.1 - 9.5e-18 62.8 5.7 0.00021 21.2 0.2 6.1 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28536.1 - 1.4e-17 62.7 0.5 0.0036 17.1 0.0 5.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28536.1 - 1.8e-16 60.2 23.0 6.7e-07 29.5 1.8 3.9 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28536.1 - 4.5e-14 51.4 0.2 0.0047 17.0 0.1 5.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28536.1 - 1.6e-10 40.3 11.6 0.14 12.2 0.3 5.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO28536.1 - 6e-08 32.4 14.9 6.2e-08 32.4 9.6 2.4 1 1 2 3 3 3 1 MalT-like TPR region TPR_4 PF07721.14 KOO28536.1 - 6e-06 26.4 21.3 0.18 12.6 0.5 7.5 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28536.1 - 7e-06 26.4 12.5 5.1 8.2 0.0 5.9 3 1 3 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28536.1 - 2.8e-05 24.7 17.7 0.0018 18.9 0.2 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28536.1 - 4.7e-05 23.5 2.5 4.3 7.9 0.0 4.8 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO28536.1 - 0.00019 21.2 11.8 0.018 14.9 0.2 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO28536.1 - 0.00046 20.6 2.5 2.2 9.1 0.1 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28536.1 - 0.0014 19.1 7.0 0.42 11.2 0.5 4.3 3 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28536.1 - 0.054 13.2 5.2 56 3.5 0.2 5.8 6 1 1 7 7 7 0 TPR repeat TPR_9 PF13371.6 KOO28536.1 - 0.1 12.8 11.5 0.48 10.6 0.8 4.1 2 2 1 3 3 3 0 Tetratricopeptide repeat V_ATPase_I_N PF18670.1 KOO28536.1 - 0.16 12.4 1.8 0.29 11.6 0.1 2.2 2 2 1 3 3 3 0 V-type ATPase subunit I, N-terminal domain Fis1_TPR_C PF14853.6 KOO28536.1 - 0.19 11.8 0.8 13 5.9 0.1 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat ANAPC5 PF12862.7 KOO28536.1 - 0.28 11.3 3.6 0.26 11.4 0.9 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 DUF3856 PF12968.7 KOO28536.1 - 0.81 9.8 4.6 4.7 7.3 0.8 2.9 1 1 2 3 3 3 0 Domain of Unknown Function (DUF3856) Glyco_tranf_2_3 PF13641.6 KOO28538.1 - 1.2e-20 74.4 0.0 1.7e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 KOO28538.1 - 9.7e-16 58.3 2.3 9.7e-16 58.3 2.3 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 KOO28538.1 - 7.7e-08 32.0 0.0 1.2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KOO28538.1 - 1.1e-06 28.6 0.0 1.6e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_29 PF00777.18 KOO28539.1 - 6.8e-28 97.8 0.0 1.3e-27 96.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Hydrolase_like PF13242.6 KOO28539.1 - 3.2e-10 39.9 0.0 7.9e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 KOO28539.1 - 1.2e-08 35.0 0.0 4.1e-08 33.3 0.0 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 KOO28539.1 - 0.19 11.3 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Borrelia_P83 PF05262.11 KOO28540.1 - 0.016 13.7 4.1 0.016 13.7 4.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein TTKRSYEDQ PF10212.9 KOO28540.1 - 0.073 12.1 1.7 0.09 11.8 1.7 1.0 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein ERM PF00769.19 KOO28540.1 - 0.56 10.0 20.8 0.66 9.8 20.8 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Presenilin PF01080.17 KOO28540.1 - 0.97 8.1 2.8 1 8.0 2.8 1.0 1 0 0 1 1 1 0 Presenilin DUF4554 PF15091.6 KOO28540.1 - 4.9 5.9 14.5 6.2 5.6 14.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Helicase_C PF00271.31 KOO28541.1 - 2.7e-10 40.6 0.0 5.6e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO28541.1 - 0.0027 17.5 0.0 0.0055 16.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase peroxidase PF00141.23 KOO28542.1 - 0.038 13.7 0.1 0.047 13.4 0.1 1.2 1 0 0 1 1 1 0 Peroxidase FluMu_N PF17891.1 KOO28542.1 - 0.11 12.3 2.3 4 7.3 0.1 2.3 1 1 1 2 2 2 0 Mu-like prophage FluMu N-terminal domain Nuc_sug_transp PF04142.15 KOO28543.1 - 6.5e-66 222.6 11.2 7.5e-66 222.4 11.2 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 KOO28543.1 - 2.3e-06 27.0 7.2 2.3e-06 27.0 7.2 2.1 2 1 1 3 3 3 1 Purine nucleobase transmembrane transport EamA PF00892.20 KOO28543.1 - 5.6e-06 26.6 6.2 5.6e-06 26.6 6.2 2.5 2 1 0 2 2 2 1 EamA-like transporter family UAA PF08449.11 KOO28543.1 - 0.039 13.2 12.8 0.031 13.5 8.7 2.5 1 1 1 2 2 2 0 UAA transporter family CRT-like PF08627.10 KOO28543.1 - 0.072 12.0 8.0 0.0083 15.1 2.6 1.9 2 0 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 KOO28543.1 - 0.11 11.8 9.3 0.14 11.5 7.8 1.9 1 1 0 1 1 1 0 Triose-phosphate Transporter family Helicase_C_2 PF13307.6 KOO28545.1 - 5.2e-40 137.4 0.0 3.8e-38 131.3 0.0 2.4 1 1 1 2 2 2 2 Helicase C-terminal domain DEAD_2 PF06733.15 KOO28545.1 - 1.2e-36 126.0 0.0 2.1e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 Torus PF16131.5 KOO28545.1 - 2.2e-29 102.3 0.7 5.3e-29 101.1 0.7 1.7 1 0 0 1 1 1 1 Torus domain RRM_1 PF00076.22 KOO28545.1 - 1.2e-06 28.2 0.0 2.7e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_22 PF13401.6 KOO28545.1 - 0.01 16.1 0.2 1.9 8.8 0.2 3.1 2 1 1 3 3 3 0 AAA domain zf-CCCH_4 PF18044.1 KOO28545.1 - 0.018 14.8 7.2 0.062 13.1 7.2 1.9 1 0 0 1 1 1 0 CCCH-type zinc finger ResIII PF04851.15 KOO28545.1 - 0.048 13.7 0.0 8 6.4 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.16 KOO28545.1 - 0.072 12.5 0.0 6.2 6.2 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein zf-CCCH_2 PF14608.6 KOO28545.1 - 0.44 11.1 5.3 1 10.0 5.3 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 KOO28545.1 - 1.8 8.7 8.1 3.7 7.7 8.1 1.6 1 0 0 1 1 1 0 Zinc finger domain DAGAT PF03982.13 KOO28546.1 - 2.5e-18 66.1 0.0 3.4e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Ank_2 PF12796.7 KOO28547.1 - 7e-19 68.2 0.0 5.8e-09 36.4 0.0 2.5 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO28547.1 - 4.3e-15 54.3 0.0 0.0047 17.3 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 KOO28547.1 - 2.9e-14 53.0 0.6 2.9e-07 30.6 0.1 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO28547.1 - 1.9e-12 47.4 0.2 4.2e-05 24.0 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO28547.1 - 4.9e-10 39.4 2.5 0.042 14.3 0.2 4.6 3 1 0 3 3 3 3 Ankyrin repeat 2OG-FeII_Oxy_3 PF13640.6 KOO28547.1 - 0.0031 18.4 0.3 0.032 15.1 0.0 2.4 1 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF45 PF01863.17 KOO28547.1 - 0.029 14.4 0.1 0.044 13.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF45 MatE PF01554.18 KOO28548.1 - 4e-30 104.6 13.2 1.7e-17 63.5 2.3 2.1 2 0 0 2 2 2 2 MatE DUF4349 PF14257.6 KOO28549.1 - 0.026 13.9 4.4 0.039 13.4 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Phage-Gp8 PF09215.10 KOO28549.1 - 0.12 11.4 0.0 0.14 11.2 0.0 1.0 1 0 0 1 1 1 0 Bacteriophage T4, Gp8 BRE1 PF08647.11 KOO28549.1 - 0.19 11.8 7.1 3.7 7.7 4.0 2.4 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase TRAF_BIRC3_bd PF16673.5 KOO28549.1 - 0.38 10.6 9.2 1.4 8.8 0.3 2.6 1 1 1 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain ATG16 PF08614.11 KOO28549.1 - 0.94 9.7 15.7 0.24 11.6 11.7 1.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 KOO28549.1 - 2.8 7.2 8.7 0.43 9.9 3.6 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) TIM PF00121.18 KOO28550.1 - 1.6e-68 230.7 0.0 1.8e-68 230.6 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Lsr2 PF11774.8 KOO28550.1 - 0.15 12.2 0.1 0.27 11.4 0.1 1.3 1 0 0 1 1 1 0 Lsr2 GST_N_3 PF13417.6 KOO28551.1 - 2.9e-15 56.5 0.0 6.7e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO28551.1 - 2.9e-14 53.1 0.1 5.4e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOO28551.1 - 7.5e-07 29.3 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOO28551.1 - 2.7e-05 24.4 0.0 8.3e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO28551.1 - 0.00054 19.9 0.1 0.0013 18.7 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 KOO28551.1 - 0.00076 19.6 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_C_5 PF16865.5 KOO28551.1 - 0.00099 19.7 0.0 0.0022 18.5 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOO28551.1 - 0.001 19.2 0.0 0.0019 18.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TniQ PF06527.11 KOO28551.1 - 0.039 14.7 0.2 0.088 13.5 0.2 1.5 1 0 0 1 1 1 0 TniQ GST_N_4 PF17172.4 KOO28551.1 - 0.049 14.4 0.0 0.41 11.4 0.0 2.2 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain Hydrolase PF00702.26 KOO28552.1 - 0.00062 20.1 0.0 0.00084 19.7 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGK PF00162.19 KOO28553.1 - 3.7e-141 470.5 0.7 4.2e-141 470.3 0.7 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Nitro_FeMo-Co PF02579.17 KOO28553.1 - 0.14 12.5 2.4 4.6 7.6 0.1 3.5 4 1 0 4 4 4 0 Dinitrogenase iron-molybdenum cofactor Pkinase PF00069.25 KOO28554.1 - 6.7e-30 104.3 0.0 3.5e-20 72.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28554.1 - 4.3e-18 65.5 0.0 6.1e-12 45.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO28554.1 - 6.9e-06 25.2 0.0 1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOO28554.1 - 0.0021 17.4 0.0 0.0032 16.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO28554.1 - 0.0022 18.0 1.4 0.011 15.7 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO28554.1 - 0.069 12.5 0.0 0.2 10.9 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Ank_2 PF12796.7 KOO28555.1 - 5.1e-38 129.5 3.7 9.6e-18 64.6 1.1 4.0 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO28555.1 - 9.6e-28 96.2 12.0 2.6e-10 40.6 0.2 5.1 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 KOO28555.1 - 2.7e-20 71.8 13.3 0.00044 20.6 0.1 7.1 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 KOO28555.1 - 4.7e-18 63.4 4.3 0.0023 18.3 0.1 7.2 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 KOO28555.1 - 7.6e-13 48.4 8.6 0.00033 20.9 0.4 5.9 3 1 2 6 6 6 4 Ankyrin repeats (many copies) I_LWEQ PF01608.17 KOO28556.1 - 0.047 13.9 0.7 2.6 8.3 0.0 2.3 2 0 0 2 2 2 0 I/LWEQ domain DUF2946 PF11162.8 KOO28556.1 - 0.17 12.6 0.7 0.4 11.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) SNF2_N PF00176.23 KOO28558.1 - 1.2e-66 224.9 0.4 2e-66 224.1 0.4 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO28558.1 - 1.9e-20 73.2 0.0 9.2e-20 71.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 KOO28558.1 - 2e-15 56.9 4.5 2e-15 56.9 4.5 3.0 3 0 0 3 3 3 1 HSA ResIII PF04851.15 KOO28558.1 - 6.2e-13 49.1 0.0 1.3e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-CXXC PF02008.20 KOO28558.1 - 2.7e-11 43.3 8.3 5e-05 23.2 2.2 2.5 2 0 0 2 2 2 2 CXXC zinc finger domain DEAD PF00270.29 KOO28558.1 - 4.5e-06 26.5 0.0 3.7e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 KOO28558.1 - 0.0066 15.7 0.0 3 6.9 0.0 2.5 2 1 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 ApbA_C PF08546.11 KOO28558.1 - 0.11 12.7 0.1 0.31 11.2 0.1 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal KRAB PF01352.27 KOO28558.1 - 1.2 8.8 5.7 34 4.2 3.7 2.8 2 0 0 2 2 2 0 KRAB box FbpA PF05833.11 KOO28559.1 - 2.9e-42 145.0 0.3 2.9e-42 145.0 0.3 2.2 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-C PF11923.8 KOO28559.1 - 1.8e-24 85.7 0.0 1.8e-24 85.7 0.0 3.6 4 0 0 4 4 4 1 NFACT protein C-terminal domain NFACT-R_1 PF05670.13 KOO28559.1 - 2.3e-20 73.2 0.0 8.7e-20 71.4 0.0 2.0 1 0 0 1 1 1 1 NFACT protein RNA binding domain EcoRI_methylase PF13651.6 KOO28559.1 - 0.04 13.2 0.8 0.078 12.2 0.0 1.8 2 0 0 2 2 2 0 Adenine-specific methyltransferase EcoRI LicD PF04991.13 KOO28559.1 - 0.092 12.9 0.8 14 5.7 0.0 2.4 2 0 0 2 2 2 0 LicD family DASH_Spc34 PF08657.10 KOO28559.1 - 8.9 6.0 11.5 0.79 9.5 0.9 2.4 2 0 0 2 2 2 0 DASH complex subunit Spc34 PKD_channel PF08016.12 KOO28560.1 - 4.3e-08 32.3 9.2 8e-08 31.4 9.2 1.4 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 KOO28560.1 - 0.13 11.5 15.5 0.011 15.0 10.6 1.7 2 0 0 2 2 2 0 Ion transport protein HsdM_N PF12161.8 KOO28560.1 - 0.39 11.3 4.0 0.52 10.9 0.8 2.5 2 0 0 2 2 2 0 HsdM N-terminal domain DUF4834 PF16118.5 KOO28560.1 - 1.3 10.1 3.7 2.7 9.0 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Ank_2 PF12796.7 KOO28562.1 - 5.3e-14 52.6 1.1 2.2e-08 34.6 0.1 2.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO28562.1 - 5.3e-12 45.7 4.9 0.00072 19.8 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28562.1 - 8.5e-12 44.2 0.3 0.0067 16.8 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KOO28562.1 - 4.8e-10 39.8 0.1 1.1e-07 32.2 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO28562.1 - 7.3e-09 35.7 3.7 0.0036 17.7 0.2 3.8 3 1 1 4 4 4 2 Ankyrin repeat HET-s_218-289 PF11558.8 KOO28562.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.5 1 0 0 1 1 1 0 Het-s 218-289 ABC1 PF03109.16 KOO28564.1 - 4.5e-21 75.2 0.0 1.2e-20 73.9 0.0 1.7 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO28564.1 - 1.4e-06 28.4 5.8 7.3e-06 26.1 1.8 3.3 3 1 1 4 4 4 2 Phosphotransferase enzyme family Pkinase PF00069.25 KOO28564.1 - 0.19 11.0 0.0 0.86 8.9 0.0 2.0 3 0 0 3 3 3 0 Protein kinase domain EF-hand_6 PF13405.6 KOO28565.1 - 1.9e-11 43.0 0.2 0.0004 20.1 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO28565.1 - 1e-10 40.4 1.0 7.7e-05 22.0 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO28565.1 - 3.5e-09 37.0 0.3 1.8e-06 28.3 0.1 4.0 3 2 1 4 4 4 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO28565.1 - 3.2e-07 30.1 0.3 6.6e-06 25.9 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO28565.1 - 0.0027 17.1 8.5 0.015 14.7 0.1 3.8 4 0 0 4 4 4 2 EF hand ACT_6 PF13740.6 KOO28565.1 - 0.18 11.8 4.2 8.6 6.4 0.0 4.3 4 1 0 4 4 4 0 ACT domain IFT57 PF10498.9 KOO28566.1 - 0.00018 20.6 13.0 0.0016 17.5 6.0 2.3 1 1 1 2 2 2 2 Intra-flagellar transport protein 57 Bacillus_HBL PF05791.11 KOO28566.1 - 0.0094 15.8 0.4 0.0094 15.8 0.4 2.5 2 0 0 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) DUF1664 PF07889.12 KOO28566.1 - 0.017 15.2 8.2 1.8 8.6 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Fez1 PF06818.15 KOO28566.1 - 0.049 14.1 38.2 0.027 14.9 12.6 3.8 3 1 1 4 4 4 0 Fez1 Fib_alpha PF08702.10 KOO28566.1 - 0.16 12.1 7.9 3.9 7.7 1.0 3.0 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Bcr-Abl_Oligo PF09036.10 KOO28566.1 - 0.3 11.1 1.9 30 4.7 0.0 3.3 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Cauli_AT PF03233.13 KOO28566.1 - 0.63 9.9 3.9 7.8 6.4 0.2 2.4 2 0 0 2 2 2 0 Aphid transmission protein Med2 PF11214.8 KOO28566.1 - 3.2 8.0 7.1 3 8.1 0.1 3.5 4 0 0 4 4 4 0 Mediator complex subunit 2 BLOC1_2 PF10046.9 KOO28566.1 - 4.3 7.7 8.9 1.9 8.8 0.2 3.2 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin PF02996.17 KOO28566.1 - 6.3 6.7 17.1 0.56 10.1 1.4 4.0 4 0 0 4 4 4 0 Prefoldin subunit DUF4537 PF15057.6 KOO28567.1 - 5.3e-08 32.9 0.0 1.6e-07 31.3 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4537) 53-BP1_Tudor PF09038.10 KOO28567.1 - 1.1e-05 25.4 0.9 0.00011 22.2 0.2 2.3 1 1 1 2 2 2 1 Tumour suppressor p53-binding protein-1 Tudor Tudor_3 PF18115.1 KOO28567.1 - 1.4e-05 24.8 0.1 5.6e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain DUF1325 PF07039.11 KOO28567.1 - 0.00043 20.4 0.0 0.002 18.2 0.0 1.9 1 1 1 2 2 2 1 SGF29 tudor-like domain TUDOR_5 PF18359.1 KOO28567.1 - 0.00052 19.6 0.0 0.0026 17.4 0.1 2.0 2 0 0 2 2 2 1 Histone methyltransferase Tudor domain 1 Tudor_2 PF18104.1 KOO28567.1 - 0.008 15.8 1.5 0.068 12.9 0.2 2.4 2 0 0 2 2 2 1 Jumonji domain-containing protein 2A Tudor domain KOW PF00467.29 KOO28567.1 - 0.16 12.0 0.1 0.48 10.5 0.1 1.8 1 0 0 1 1 1 0 KOW motif Ank_2 PF12796.7 KOO28568.1 - 2.2e-11 44.2 0.0 4.8e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO28568.1 - 3.7e-11 43.0 2.0 0.00049 20.4 0.0 3.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 KOO28568.1 - 2.8e-09 37.3 0.1 1.5e-08 35.0 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28568.1 - 8e-09 35.0 0.2 0.0029 18.0 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOO28568.1 - 0.0001 22.5 0.1 0.0071 16.6 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) ATXN-1_C PF12547.8 KOO28568.1 - 0.22 11.9 5.6 0.061 13.7 2.2 1.9 2 0 0 2 2 2 0 Capicua transcriptional repressor modulator CDC27 PF09507.10 KOO28568.1 - 2.2 7.6 20.0 3.4 6.9 20.0 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ribonuclease_T2 PF00445.18 KOO28570.1 - 8e-07 29.5 0.2 1.9e-06 28.2 0.2 1.5 1 1 0 1 1 1 1 Ribonuclease T2 family Glyco_transf_25 PF01755.17 KOO28571.1 - 3.4e-26 92.4 0.0 8e-26 91.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) MMR_HSR1 PF01926.23 KOO28573.1 - 2.5e-21 75.9 0.0 3.4e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOO28573.1 - 2.1e-09 37.1 0.0 2.6e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KOO28573.1 - 3.7e-06 26.9 0.0 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 KOO28573.1 - 0.00027 21.1 0.0 0.0023 18.0 0.1 1.9 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 KOO28573.1 - 0.012 15.2 0.0 0.67 9.5 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KOO28573.1 - 0.034 13.5 0.0 0.049 12.9 0.0 1.1 1 0 0 1 1 1 0 AIG1 family AAA_29 PF13555.6 KOO28573.1 - 0.041 13.6 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 KOO28573.1 - 0.069 13.7 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_21 PF13304.6 KOO28573.1 - 0.12 12.2 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 KOO28573.1 - 0.21 11.8 0.0 0.43 10.8 0.0 1.6 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 KOO28573.1 - 0.3 10.8 0.0 0.41 10.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Methyltr_RsmB-F PF01189.17 KOO28574.1 - 3.5e-29 101.9 0.1 5.6e-27 94.7 0.0 3.2 3 1 0 3 3 3 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 KOO28574.1 - 0.15 12.6 0.0 0.33 11.5 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 KOO28574.1 - 0.15 12.2 0.0 0.29 11.2 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase RCC1 PF00415.18 KOO28575.1 - 1.1e-16 61.2 1.5 3.4e-09 37.2 0.0 2.3 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO28575.1 - 9.4e-07 28.5 0.8 3e-05 23.7 0.5 2.6 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat APG6_N PF17675.1 KOO28576.1 - 0.027 15.0 8.1 0.043 14.3 8.1 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region TMF_TATA_bd PF12325.8 KOO28576.1 - 0.032 14.5 5.1 0.06 13.6 5.1 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 KOO28576.1 - 0.36 9.7 6.3 0.44 9.4 6.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Linocin_M18 PF04454.12 KOO28576.1 - 0.53 9.5 4.9 0.31 10.3 2.4 1.7 1 1 1 2 2 2 0 Encapsulating protein for peroxidase CENP-H PF05837.12 KOO28576.1 - 0.82 10.1 7.1 1.3 9.5 6.4 1.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) TPR_1 PF00515.28 KOO28577.1 - 4e-10 39.1 7.4 0.00087 19.0 0.2 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28577.1 - 3.4e-09 36.7 8.4 0.00015 21.8 1.6 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28577.1 - 5.7e-08 32.3 15.0 0.0017 18.3 1.0 4.6 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28577.1 - 1.8e-07 30.7 5.4 0.009 15.7 0.2 3.6 2 2 1 3 3 3 3 TPR repeat TPR_12 PF13424.6 KOO28577.1 - 2e-06 28.0 1.8 2e-06 28.0 1.8 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28577.1 - 2.1e-05 25.1 28.8 0.00048 20.7 4.2 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28577.1 - 2.5e-05 24.0 6.4 0.29 11.2 0.2 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO28577.1 - 0.00042 20.1 19.2 0.11 12.4 0.1 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat IstB_IS21_ATP PF08483.11 KOO28577.1 - 0.038 13.9 1.7 5.4 7.0 0.4 3.1 2 0 0 2 2 2 0 IstB-like ATP binding N-terminal TPR_8 PF13181.6 KOO28577.1 - 0.058 13.6 3.8 2.1 8.8 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28577.1 - 0.21 12.5 29.9 0.15 13.0 1.2 6.5 4 1 3 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28577.1 - 0.22 12.0 7.1 4.5 7.9 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28577.1 - 9.8 6.8 16.5 0.39 11.3 1.6 3.7 2 1 4 6 6 5 0 Tetratricopeptide repeat Filamin PF00630.19 KOO28578.1 - 4.5e-19 69.2 0.0 4.7e-16 59.5 0.1 2.4 2 0 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO28578.1 - 0.00074 19.8 0.2 0.0015 18.8 0.2 1.5 1 0 0 1 1 1 1 Invasin, domain 3 Herpes_UL25 PF01499.16 KOO28578.1 - 0.16 10.4 1.7 0.21 10.1 1.7 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family RNA_pol_A_bac PF01000.26 KOO28580.1 - 2.1e-27 95.7 0.0 3.3e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KOO28580.1 - 8e-23 79.7 0.0 1.5e-22 78.8 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_7 PF12838.7 KOO28580.1 - 0.047 14.3 1.2 0.098 13.3 1.2 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 KOO28580.1 - 0.061 13.5 0.8 0.13 12.4 0.8 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer2 PF00111.27 KOO28582.1 - 4.9e-10 39.2 0.5 8.2e-10 38.5 0.5 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF5585 PF17823.1 KOO28583.1 - 0.85 8.5 3.6 1.3 7.9 3.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) DUF465 PF04325.13 KOO28583.1 - 9.1 6.4 11.0 71 3.6 0.1 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF465) Kinesin PF00225.23 KOO28584.1 - 9.4e-62 208.9 0.0 1.5e-61 208.2 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO28584.1 - 1.3e-13 51.1 0.0 2.5e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding zf-C3HC4_2 PF13923.6 KOO28584.1 - 9.6e-07 28.5 9.0 9.6e-07 28.5 9.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO28584.1 - 6e-05 22.8 8.4 6e-05 22.8 8.4 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 KOO28584.1 - 0.001 18.9 5.5 0.0024 17.7 5.5 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 KOO28584.1 - 0.0011 19.1 7.7 0.0027 17.8 7.7 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-C3HC4_3 PF13920.6 KOO28584.1 - 0.0017 18.2 11.3 0.0048 16.7 11.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO28584.1 - 0.0055 17.0 9.3 0.0055 17.0 9.3 2.7 3 0 0 3 3 2 1 Ring finger domain zf-RING_5 PF14634.6 KOO28584.1 - 0.012 15.6 7.7 0.012 15.6 7.7 2.1 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO28584.1 - 0.054 13.5 6.4 0.028 14.4 3.8 1.9 1 1 0 1 1 1 0 RING-type zinc-finger DbpA PF03880.15 KOO28584.1 - 0.09 12.8 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 DbpA RNA binding domain Prok-RING_4 PF14447.6 KOO28584.1 - 0.45 10.4 11.2 1.1 9.2 11.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF3138 PF11336.8 KOO28584.1 - 1.1 7.8 5.9 1.8 7.1 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) zf-Nse PF11789.8 KOO28584.1 - 1.3 8.9 4.9 3.3 7.6 4.9 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit EF-hand_1 PF00036.32 KOO28586.1 - 1.1e-08 34.0 0.1 2.9e-05 23.3 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO28586.1 - 1.6e-08 33.8 0.0 6.6e-05 22.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO28586.1 - 3.4e-07 30.6 0.8 0.00051 20.4 0.1 3.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO28586.1 - 1.5e-05 24.3 0.4 0.00069 19.0 0.1 2.9 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO28586.1 - 0.0011 18.8 0.1 0.0069 16.2 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair DUF1192 PF06698.11 KOO28586.1 - 0.022 14.8 0.1 0.022 14.8 0.1 9.2 9 1 1 10 10 10 0 Protein of unknown function (DUF1192) Lipoprotein_6 PF01441.19 KOO28586.1 - 0.83 9.6 4.4 4.2 7.4 0.1 3.3 3 0 0 3 3 3 0 Lipoprotein Reprolysin PF01421.19 KOO28588.1 - 0.35 10.8 0.3 0.53 10.1 0.3 1.2 1 0 0 1 1 1 0 Reprolysin (M12B) family zinc metalloprotease Ank_2 PF12796.7 KOO28589.1 - 1.7e-07 31.7 0.2 3.4e-07 30.8 0.2 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO28589.1 - 2.9e-07 30.7 2.0 7.9e-07 29.2 0.6 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28589.1 - 5e-07 29.5 0.2 0.0017 18.7 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KOO28589.1 - 2.3e-06 28.0 0.1 5.2e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO28589.1 - 4.2e-06 26.9 0.6 0.00056 20.2 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat EF-hand_7 PF13499.6 KOO28590.1 - 8.4e-19 67.8 0.9 2.3e-08 34.3 0.0 4.4 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.6 KOO28590.1 - 3.1e-18 64.1 0.1 0.0013 18.5 0.0 5.6 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 KOO28590.1 - 1e-17 62.3 1.5 0.0045 16.4 0.0 5.4 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 KOO28590.1 - 1.7e-15 55.7 9.3 0.0062 16.0 0.1 5.7 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO28590.1 - 5e-06 26.3 0.4 2.6 8.0 0.1 4.8 4 1 0 4 4 4 1 EF-hand domain pair Dockerin_1 PF00404.18 KOO28590.1 - 0.00013 22.1 0.2 2.8 8.2 0.0 4.0 4 0 0 4 4 4 2 Dockerin type I domain VCBS PF13517.6 KOO28590.1 - 0.013 16.0 6.3 1.4 9.6 0.3 3.6 3 0 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella HZS_alpha PF18582.1 KOO28590.1 - 0.035 14.6 0.0 0.14 12.7 0.0 2.0 2 1 0 2 2 2 0 Hydrazine synthase alpha subunit middle domain SPARC_Ca_bdg PF10591.9 KOO28590.1 - 0.074 13.4 0.0 2.1 8.7 0.0 2.9 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region FG-GAP PF01839.23 KOO28590.1 - 1.6 8.9 13.5 2.2 8.5 0.3 3.7 3 0 0 3 3 3 0 FG-GAP repeat EF-hand_7 PF13499.6 KOO28592.1 - 5.4e-13 49.2 0.0 1.6e-06 28.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO28592.1 - 7.7e-13 47.0 0.0 2.3e-05 23.6 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KOO28592.1 - 4.4e-12 44.9 0.0 8.5e-06 25.3 0.0 3.5 4 1 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KOO28592.1 - 1.8e-10 39.8 0.0 1.1e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO28592.1 - 2.6e-07 30.9 0.0 0.00016 21.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO28592.1 - 5.3e-05 23.0 0.1 0.033 14.0 0.0 3.6 3 1 1 4 4 4 2 EF-hand domain pair CDC45 PF02724.14 KOO28593.1 - 0.21 9.8 4.3 0.29 9.4 4.3 1.2 1 0 0 1 1 1 0 CDC45-like protein HalX PF08663.10 KOO28594.1 - 0.015 15.6 5.6 0.017 15.4 2.9 2.3 1 1 1 2 2 2 0 HalX domain Rod-binding PF10135.9 KOO28595.1 - 0.07 13.7 0.7 0.07 13.7 0.7 1.9 2 1 0 2 2 2 0 Rod binding protein DUF962 PF06127.11 KOO28596.1 - 0.31 11.2 13.9 6.4 6.9 0.0 5.3 3 1 0 3 3 3 0 Protein of unknown function (DUF962) DUF2681 PF10883.8 KOO28596.1 - 0.39 11.1 1.0 6.2 7.3 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) Tom5 PF10642.9 KOO28596.1 - 9.6 6.3 10.3 10 6.2 0.4 4.0 4 0 0 4 4 4 0 Mitochondrial import receptor subunit or translocase LRR_6 PF13516.6 KOO28597.1 - 2.4e-27 92.6 17.4 0.00093 19.1 0.0 9.1 10 0 0 10 10 10 7 Leucine Rich repeat LRR_1 PF00560.33 KOO28597.1 - 1.1e-06 28.3 0.3 10 7.1 0.0 6.8 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_4 PF12799.7 KOO28597.1 - 1.4e-06 28.5 6.2 0.19 12.2 0.0 5.3 3 1 4 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO28597.1 - 0.24 11.2 14.3 16 5.3 0.6 6.4 5 2 2 7 7 7 0 Leucine rich repeat adh_short PF00106.25 KOO28599.1 - 3.3e-39 134.4 1.4 4.2e-39 134.0 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO28599.1 - 3.1e-27 95.7 4.0 4.2e-27 95.2 4.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO28599.1 - 2.1e-10 40.8 3.0 3.6e-10 40.1 3.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOO28599.1 - 0.08 12.4 0.6 0.15 11.5 0.6 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 KOO28599.1 - 0.13 12.5 0.3 0.22 11.8 0.3 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NB-ARC PF00931.22 KOO28600.1 - 5.6e-07 29.0 0.0 0.0012 18.0 0.0 2.6 2 1 1 3 3 3 2 NB-ARC domain RRM_1 PF00076.22 KOO28601.1 - 0.082 12.7 0.0 0.47 10.3 0.0 2.2 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Doppel PF11466.8 KOO28601.1 - 0.12 12.0 0.2 0.36 10.5 0.2 1.8 1 0 0 1 1 1 0 Prion-like protein Doppel PCuAC PF04314.13 KOO28602.1 - 0.03 14.1 0.1 0.063 13.1 0.1 1.6 1 0 0 1 1 1 0 Copper chaperone PCu(A)C PIN_5 PF08745.11 KOO28602.1 - 0.11 11.9 1.6 0.11 12.0 0.4 1.6 2 0 0 2 2 2 0 PINc domain ribonuclease TerB PF05099.13 KOO28602.1 - 0.94 9.4 13.7 0.21 11.5 8.9 1.9 1 1 1 2 2 2 0 Tellurite resistance protein TerB TPR_MLP1_2 PF07926.12 KOO28602.1 - 6.7 6.8 15.5 1 9.5 5.4 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein UBA PF00627.31 KOO28603.1 - 0.059 13.3 0.0 0.25 11.3 0.0 2.2 1 1 0 1 1 1 0 UBA/TS-N domain TMEM108 PF15759.5 KOO28604.1 - 0.066 12.2 0.0 0.075 12.0 0.0 1.0 1 0 0 1 1 1 0 TMEM108 family DUF3100 PF11299.8 KOO28604.1 - 0.11 11.9 0.2 0.17 11.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3100) Arm PF00514.23 KOO28606.1 - 1.8e-34 116.7 12.4 4.6e-09 36.0 0.1 7.3 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO28606.1 - 4.8e-05 23.3 0.5 0.15 12.1 0.2 4.4 3 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain HEAT_PBS PF03130.16 KOO28606.1 - 0.038 14.7 6.4 21 6.1 0.9 4.6 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat HEAT_2 PF13646.6 KOO28606.1 - 0.15 12.5 12.8 1.4 9.4 3.4 4.0 1 1 1 3 3 3 0 HEAT repeats HEAT_EZ PF13513.6 KOO28606.1 - 0.35 11.4 14.3 7.8 7.1 0.8 4.9 2 1 2 4 4 4 0 HEAT-like repeat DUF1129 PF06570.11 KOO28607.1 - 0.15 11.6 1.6 0.2 11.1 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF2207 PF09972.9 KOO28607.1 - 0.2 10.4 0.4 0.22 10.3 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3810 PF12725.7 KOO28607.1 - 0.47 9.7 3.2 0.64 9.3 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Kinesin PF00225.23 KOO28608.1 - 4e-79 266.0 0.0 4.8e-79 265.7 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO28608.1 - 4.9e-14 52.5 0.0 7.7e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding AAA_22 PF13401.6 KOO28608.1 - 0.15 12.3 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain zf-CCHC_4 PF14392.6 KOO28609.1 - 0.12 12.1 0.3 11 5.8 0.2 2.3 2 0 0 2 2 2 0 Zinc knuckle Acid_PPase PF12689.7 KOO28611.1 - 0.044 13.6 0.1 0.32 10.8 0.1 2.1 1 1 0 1 1 1 0 Acid Phosphatase DUF2608 PF11019.8 KOO28611.1 - 0.071 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) DivIC PF04977.15 KOO28612.1 - 0.005 16.6 0.2 0.0082 15.9 0.2 1.3 1 0 0 1 1 1 1 Septum formation initiator HALZ PF02183.18 KOO28612.1 - 0.039 14.2 0.4 0.057 13.7 0.4 1.2 1 0 0 1 1 1 0 Homeobox associated leucine zipper Mto2_bdg PF12808.7 KOO28612.1 - 0.042 14.1 0.3 0.074 13.4 0.3 1.4 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Ank_2 PF12796.7 KOO28613.1 - 3e-22 79.0 0.4 5.2e-12 46.2 0.0 2.8 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO28613.1 - 1.4e-21 76.5 0.3 1.8e-08 34.8 0.0 3.8 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO28613.1 - 8.4e-20 70.6 2.9 3.5e-08 33.6 0.0 4.4 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28613.1 - 1.7e-15 55.6 0.1 0.0015 18.9 0.0 6.0 5 1 1 6 6 6 3 Ankyrin repeat Ank PF00023.30 KOO28613.1 - 8.3e-08 32.4 0.2 0.02 15.4 0.0 4.2 3 1 0 3 3 3 2 Ankyrin repeat Bacteriocin_IIi PF11758.8 KOO28613.1 - 1.3 8.9 6.1 26 4.8 0.0 3.8 4 1 0 4 4 4 0 Aureocin-like type II bacteriocin Glyco_transf_64 PF09258.10 KOO28614.1 - 0.0033 16.7 0.0 0.0063 15.8 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 64 domain Radical_SAM PF04055.21 KOO28614.1 - 0.078 13.4 0.2 0.29 11.5 0.1 2.0 2 0 0 2 2 2 0 Radical SAM superfamily Fer4_12 PF13353.6 KOO28614.1 - 0.2 12.0 0.3 0.54 10.5 0.2 1.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain ShK PF01549.24 KOO28614.1 - 1.5 9.4 8.6 0.82 10.3 4.6 2.5 2 1 0 2 2 2 0 ShK domain-like Methyltransf_25 PF13649.6 KOO28615.1 - 3.1e-07 31.0 0.0 1e-06 29.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO28615.1 - 3.6e-06 26.6 0.0 6.8e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 KOO28615.1 - 0.00013 21.7 0.0 0.00025 20.7 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 KOO28615.1 - 0.00019 21.0 0.3 0.00089 18.9 0.1 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.12 KOO28615.1 - 0.00027 21.5 0.0 0.00094 19.8 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO28615.1 - 0.00046 20.0 0.0 0.00092 19.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOO28615.1 - 0.0011 18.7 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 KOO28615.1 - 0.0023 17.7 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_32 PF13679.6 KOO28615.1 - 0.0028 17.7 2.1 0.022 14.7 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_16 PF10294.9 KOO28615.1 - 0.0039 16.9 0.0 0.0077 16.0 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_18 PF12847.7 KOO28615.1 - 0.0094 15.9 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO28615.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 KOO28615.1 - 0.08 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain LRR_6 PF13516.6 KOO28616.1 - 1e-10 40.7 8.4 0.007 16.3 0.0 5.5 6 0 0 6 6 6 4 Leucine Rich repeat LRR_8 PF13855.6 KOO28616.1 - 0.00016 21.4 0.2 1.2 8.9 0.0 3.9 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 KOO28616.1 - 0.0012 19.2 0.3 12 6.5 0.1 3.6 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) APP_Cu_bd PF12924.7 KOO28620.1 - 0.092 13.5 2.0 0.25 12.1 2.0 1.8 1 0 0 1 1 1 0 Copper-binding of amyloid precursor, CuBD Cript PF10235.9 KOO28622.1 - 1.7e-21 76.6 3.5 4.6e-21 75.2 3.5 1.8 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT Tyr-DNA_phospho PF06087.12 KOO28622.1 - 0.064 12.1 0.0 0.078 11.9 0.0 1.1 1 0 0 1 1 1 0 Tyrosyl-DNA phosphodiesterase DUF2039 PF10217.9 KOO28622.1 - 2.4 8.5 11.8 0.45 10.9 7.3 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) Acyltransferase PF01553.21 KOO28623.1 - 1.1e-08 34.8 0.0 2.5e-08 33.6 0.0 1.6 1 1 0 1 1 1 1 Acyltransferase Bromodomain PF00439.25 KOO28624.1 - 8.9e-45 150.7 0.0 1.4e-21 76.3 0.0 2.3 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 KOO28624.1 - 8.1e-13 48.3 0.4 1.6e-12 47.4 0.4 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation HALZ PF02183.18 KOO28625.1 - 0.021 15.0 1.0 0.14 12.4 0.3 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper OmpH PF03938.14 KOO28625.1 - 0.28 11.5 17.1 2.7 8.3 7.8 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3584 PF12128.8 KOO28625.1 - 0.43 8.0 22.7 0.025 12.1 8.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 KOO28625.1 - 0.5 10.8 12.6 2.3 8.7 4.4 2.4 2 0 0 2 2 2 0 Fez1 AAA PF00004.29 KOO28626.1 - 1e-16 61.5 0.0 1.8e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO28626.1 - 7.9e-05 23.1 0.1 0.0011 19.3 0.0 2.3 2 1 1 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 KOO28626.1 - 0.0045 17.5 0.0 0.0084 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO28626.1 - 0.0059 16.6 0.1 0.027 14.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 KOO28626.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 KOO28626.1 - 0.012 15.9 0.0 0.023 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KOO28626.1 - 0.012 14.9 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 KOO28626.1 - 0.012 15.7 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 KOO28626.1 - 0.021 15.1 0.0 0.04 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KOO28626.1 - 0.027 14.5 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 KOO28626.1 - 0.031 13.8 0.0 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 KOO28626.1 - 0.035 14.0 0.0 0.062 13.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DUF815 PF05673.13 KOO28626.1 - 0.04 13.1 0.1 0.1 11.7 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 KOO28626.1 - 0.047 14.2 0.0 0.077 13.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 KOO28626.1 - 0.09 12.3 0.1 0.33 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOO28626.1 - 0.092 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RuvB_N PF05496.12 KOO28626.1 - 0.13 12.0 0.0 0.34 10.6 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain RsgA_GTPase PF03193.16 KOO28626.1 - 0.13 12.2 0.0 0.39 10.6 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 KOO28626.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 KOO28626.1 - 0.14 11.2 0.0 0.28 10.3 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain ATPase PF06745.13 KOO28626.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 KaiC PDZ PF00595.24 KOO28627.1 - 5.5e-05 23.4 0.5 8.4e-05 22.8 0.5 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO28627.1 - 0.00045 20.5 0.3 0.00076 19.8 0.3 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO28627.1 - 0.026 14.3 0.3 0.042 13.7 0.3 1.3 1 0 0 1 1 1 0 PDZ domain SHIPPO-rpt PF07004.12 KOO28628.1 - 0.3 12.1 1.8 0.42 11.6 0.7 1.9 2 1 0 2 2 2 0 Sperm-tail PG-rich repeat NHL PF01436.21 KOO28629.1 - 0.00033 20.6 0.6 2.8 8.1 0.1 3.8 4 0 0 4 4 4 2 NHL repeat PQQ_3 PF13570.6 KOO28629.1 - 0.14 12.7 1.7 19 5.9 0.0 2.9 2 1 0 2 2 2 0 PQQ-like domain BTHB PF18410.1 KOO28630.1 - 8e-05 22.4 0.1 0.00042 20.1 0.0 2.2 2 0 0 2 2 2 1 Basic tilted helix bundle domain SAP PF02037.27 KOO28630.1 - 0.0033 17.2 0.6 0.023 14.4 0.0 2.6 2 0 0 2 2 2 1 SAP domain HATPase_c_3 PF13589.6 KOO28630.1 - 0.026 14.3 0.0 0.077 12.8 0.0 1.7 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF5600 PF18150.1 KOO28631.1 - 1.8e-22 79.9 0.0 3.2e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) Dynamin_N PF00350.23 KOO28631.1 - 1.4e-14 54.5 0.0 4.2e-14 52.9 0.0 1.8 1 1 0 1 1 1 1 Dynamin family EHD_N PF16880.5 KOO28631.1 - 1.7e-08 34.2 1.1 2.9e-08 33.4 0.1 2.0 2 0 0 2 2 2 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.23 KOO28631.1 - 2.1e-08 34.2 0.0 5.2e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 KOO28631.1 - 0.0037 17.5 0.0 0.34 11.1 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 KOO28631.1 - 0.067 13.1 0.0 15 5.5 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase Gtr1_RagA PF04670.12 KOO28631.1 - 0.13 11.6 0.0 0.75 9.1 0.0 2.2 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region CobS PF02654.15 KOO28632.1 - 2.4e-40 138.9 13.7 3.5e-40 138.4 13.7 1.2 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase TetR_C_28 PF17937.1 KOO28632.1 - 0.1 13.0 0.7 0.1 13.0 0.7 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain adh_short_C2 PF13561.6 KOO28634.1 - 6.2e-34 117.6 7.9 4.3e-30 105.0 1.7 3.1 2 1 1 3 3 3 3 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO28634.1 - 3.6e-26 91.8 2.4 1.3e-24 86.7 0.5 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 KOO28634.1 - 5.5e-15 55.7 2.5 5.5e-15 55.7 2.5 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 KOO28634.1 - 0.014 14.9 0.1 0.021 14.3 0.1 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family HAT PF02184.16 KOO28635.1 - 1.1e-22 79.7 58.1 8.5e-10 38.4 0.5 13.5 13 1 0 13 13 13 5 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 KOO28635.1 - 1.9e-16 59.3 42.2 0.0041 17.8 0.3 12.7 5 3 9 14 14 13 5 Tetratricopeptide repeat Suf PF05843.14 KOO28635.1 - 6.2e-16 59.2 11.3 4.9e-06 26.7 3.9 5.6 2 2 1 4 4 4 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 KOO28635.1 - 2.2e-14 53.7 11.9 0.089 13.3 0.2 7.6 6 2 2 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28635.1 - 1.8e-06 27.6 19.1 11 6.5 0.0 10.2 12 0 0 12 12 12 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO28635.1 - 3.8e-06 27.4 22.9 0.86 10.3 0.0 8.4 7 2 2 10 10 10 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28635.1 - 5.3e-06 26.5 4.7 0.051 14.0 0.1 6.0 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO28635.1 - 7.9e-05 22.0 26.3 0.089 12.0 1.4 4.7 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28635.1 - 0.00028 20.8 0.1 88 3.7 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KOO28635.1 - 0.00071 19.6 18.1 1.8 8.5 0.4 6.4 5 2 2 7 7 7 2 Mad3/BUB1 homology region 1 Utp13 PF08625.11 KOO28635.1 - 0.0049 16.8 1.1 0.063 13.2 0.1 2.7 3 0 0 3 3 3 1 Utp13 specific WD40 associated domain TPR_7 PF13176.6 KOO28635.1 - 0.018 15.0 5.5 7.7 6.8 0.0 5.1 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28635.1 - 0.019 15.1 21.8 0.11 12.6 0.4 6.1 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO28635.1 - 0.21 12.3 19.8 5.9 7.7 0.1 8.9 10 0 0 10 10 8 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 KOO28635.1 - 0.23 11.4 4.3 0.43 10.5 0.3 3.3 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal Ribosomal_S19 PF00203.21 KOO28636.1 - 5.3e-14 51.9 0.1 6.1e-14 51.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 PD-C2-AF1 PF09310.10 KOO28636.1 - 0.023 14.1 0.5 0.031 13.7 0.5 1.2 1 0 0 1 1 1 0 POU domain, class 2, associating factor 1 IQ PF00612.27 KOO28637.1 - 2.6e-08 33.0 0.6 0.0019 17.8 0.0 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif X PF00739.19 KOO28637.1 - 6.2 6.9 12.7 0.17 12.0 4.6 2.6 2 0 0 2 2 2 0 Trans-activation protein X Pkinase PF00069.25 KOO28638.1 - 1.2e-59 201.8 0.0 2.3e-59 200.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28638.1 - 9.2e-34 116.9 0.1 3.4e-33 115.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Response_reg PF00072.24 KOO28638.1 - 7.3e-12 45.5 0.0 1.7e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Pkinase_fungal PF17667.1 KOO28638.1 - 7.5e-05 21.7 0.2 0.00037 19.4 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOO28638.1 - 0.012 14.9 0.2 0.042 13.2 0.0 2.1 3 1 0 3 3 3 0 Kinase-like zf-C2HC_2 PF13913.6 KOO28638.1 - 0.65 10.0 2.0 0.44 10.5 0.3 1.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type eIF3_subunit PF08597.10 KOO28639.1 - 0.026 14.4 1.8 0.032 14.1 1.8 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Myb_DNA-bind_6 PF13921.6 KOO28640.1 - 0.00016 21.8 0.0 0.00021 21.5 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 KOO28640.1 - 0.0017 18.5 0.0 0.0025 18.0 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Methyltransf_1N PF02870.15 KOO28640.1 - 0.14 13.0 0.0 0.29 12.0 0.0 1.5 1 1 1 2 2 2 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Glyoxalase_4 PF13669.6 KOO28641.1 - 0.081 13.2 0.0 1.9 8.8 0.0 2.4 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AAA PF00004.29 KOO28642.1 - 2e-31 109.1 0.0 2.7e-10 40.8 0.0 4.0 4 0 0 4 4 3 3 ATPase family associated with various cellular activities (AAA) MIB_HERC2 PF06701.13 KOO28642.1 - 3.3e-15 56.1 6.2 1.1e-14 54.4 6.2 2.0 1 0 0 1 1 1 1 Mib_herc2 AAA_lid_6 PF17866.1 KOO28642.1 - 2.1e-13 50.3 11.5 7.5e-05 22.8 0.1 4.3 5 0 0 5 5 3 3 AAA lid domain SH3_15 PF18346.1 KOO28642.1 - 2.8e-10 40.4 3.3 2.3e-07 31.0 0.3 3.9 3 0 0 3 3 3 1 Mind bomb SH3 repeat domain AAA_30 PF13604.6 KOO28642.1 - 9.4e-10 38.5 1.0 0.039 13.7 0.0 3.9 3 0 0 3 3 3 3 AAA domain AAA_22 PF13401.6 KOO28642.1 - 5.9e-09 36.3 6.8 0.19 12.0 0.2 6.0 3 3 1 4 4 4 2 AAA domain AAA_5 PF07728.14 KOO28642.1 - 8.6e-09 35.5 4.6 0.22 11.5 0.0 4.6 4 0 0 4 4 4 3 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOO28642.1 - 1.7e-08 34.4 0.2 0.074 12.8 0.0 3.6 3 0 0 3 3 3 3 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO28642.1 - 9.5e-08 32.6 0.4 0.44 10.9 0.0 4.3 3 0 0 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 KOO28642.1 - 9.4e-07 29.4 3.9 0.065 13.8 0.0 3.8 3 0 0 3 3 3 2 AAA domain PDZ_6 PF17820.1 KOO28642.1 - 1.4e-06 28.0 0.9 0.0001 22.0 0.1 3.4 2 0 0 2 2 2 1 PDZ domain Mg_chelatase PF01078.21 KOO28642.1 - 1.9e-06 27.4 2.4 0.74 9.2 0.2 4.4 3 1 0 4 4 4 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KOO28642.1 - 6.3e-06 26.0 0.2 1.3 8.7 0.0 3.6 3 0 0 3 3 3 2 IstB-like ATP binding protein TniB PF05621.11 KOO28642.1 - 1.7e-05 24.3 0.0 1.4 8.3 0.0 5.1 5 1 1 6 6 6 1 Bacterial TniB protein AAA_24 PF13479.6 KOO28642.1 - 2.4e-05 24.1 1.5 1.2 8.8 0.0 3.6 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 KOO28642.1 - 3.7e-05 23.6 0.3 0.53 10.0 0.0 3.7 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 KOO28642.1 - 7.3e-05 23.1 2.3 1.1 9.4 0.0 4.2 4 0 0 4 4 3 1 AAA domain Sigma54_activat PF00158.26 KOO28642.1 - 0.00012 21.8 0.3 7.8 6.2 0.0 4.6 4 1 0 4 4 4 0 Sigma-54 interaction domain RNA_helicase PF00910.22 KOO28642.1 - 0.00016 22.0 0.4 4.7 7.7 0.0 3.8 3 0 0 3 3 3 0 RNA helicase ABC_tran PF00005.27 KOO28642.1 - 0.00016 22.2 0.9 3.2 8.3 0.0 3.9 3 0 0 3 3 3 1 ABC transporter PDZ PF00595.24 KOO28642.1 - 0.00018 21.8 1.0 0.00039 20.7 0.3 2.0 2 0 0 2 2 1 1 PDZ domain AAA_19 PF13245.6 KOO28642.1 - 0.00023 21.5 3.0 3.8 7.8 0.1 4.1 3 0 0 3 3 3 1 AAA domain PDZ_2 PF13180.6 KOO28642.1 - 0.00046 20.4 0.2 0.0021 18.4 0.0 2.1 2 0 0 2 2 1 1 PDZ domain TsaE PF02367.17 KOO28642.1 - 0.00062 19.8 0.4 2.4 8.2 0.0 3.4 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 KOO28642.1 - 0.00067 19.6 4.0 3.3 7.6 0.1 3.4 3 0 0 3 3 3 1 NTPase AAA_33 PF13671.6 KOO28642.1 - 0.0018 18.4 9.7 0.38 10.9 0.1 4.0 4 1 0 4 4 3 1 AAA domain AAA_2 PF07724.14 KOO28642.1 - 0.0038 17.4 0.0 1.3 9.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 KOO28642.1 - 0.0046 17.1 0.1 0.22 11.7 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain Torsin PF06309.11 KOO28642.1 - 0.024 14.7 0.2 0.42 10.7 0.0 2.8 3 0 0 3 3 3 0 Torsin AAA_29 PF13555.6 KOO28642.1 - 0.024 14.4 0.1 30 4.5 0.0 3.5 3 0 0 3 3 3 0 P-loop containing region of AAA domain KTI12 PF08433.10 KOO28642.1 - 0.037 13.5 0.4 16 4.8 0.0 3.1 3 0 0 3 3 3 0 Chromatin associated protein KTI12 AAA_7 PF12775.7 KOO28642.1 - 0.047 13.2 3.4 19 4.7 0.0 3.3 3 0 0 3 3 3 0 P-loop containing dynein motor region CbiA PF01656.23 KOO28642.1 - 0.049 13.7 2.8 10 6.2 0.2 3.5 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain MCM PF00493.23 KOO28642.1 - 0.051 12.7 0.0 6.4 5.8 0.0 3.3 3 0 0 3 3 3 0 MCM P-loop domain MobB PF03205.14 KOO28642.1 - 0.13 12.2 3.1 6.6 6.6 0.0 3.0 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 KOO28642.1 - 0.15 11.6 2.3 45 3.5 0.0 4.3 3 1 0 4 4 4 0 AAA domain AAA_17 PF13207.6 KOO28642.1 - 0.18 12.3 7.1 24 5.4 0.0 4.5 4 0 0 4 4 4 0 AAA domain APS_kinase PF01583.20 KOO28642.1 - 0.18 11.7 0.8 23 4.8 0.1 3.2 3 0 0 3 3 3 0 Adenylylsulphate kinase Thymidylate_kin PF02223.17 KOO28642.1 - 0.66 9.6 4.1 18 4.9 0.2 3.3 3 0 0 3 3 3 0 Thymidylate kinase MeaB PF03308.16 KOO28642.1 - 0.74 8.7 4.9 6.7 5.6 0.1 2.7 3 0 0 3 3 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase PF06745.13 KOO28642.1 - 1.1 8.6 5.1 36 3.6 0.0 3.7 4 0 0 4 4 4 0 KaiC NACHT PF05729.12 KOO28642.1 - 1.8 8.4 4.0 26 4.7 0.1 3.3 3 0 0 3 3 3 0 NACHT domain SKI PF01202.22 KOO28642.1 - 4.2 7.5 5.8 71 3.5 0.1 4.0 4 0 0 4 4 4 0 Shikimate kinase Carboxyl_trans PF01039.22 KOO28643.1 - 9.9e-189 628.1 0.1 1.2e-188 627.8 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 KOO28643.1 - 0.0075 15.8 0.1 0.0075 15.8 0.1 2.5 3 0 0 3 3 3 1 Malonate decarboxylase gamma subunit (MdcE) Arm PF00514.23 KOO28644.1 - 5.5e-08 32.6 5.2 9.8e-06 25.4 0.3 2.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat EF-hand_1 PF00036.32 KOO28644.1 - 0.018 14.5 0.1 0.056 13.0 0.0 1.8 2 0 0 2 2 2 0 EF hand EF-hand_5 PF13202.6 KOO28644.1 - 0.021 14.3 0.0 0.058 12.9 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 KOO28644.1 - 0.036 13.9 0.1 0.095 12.6 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_7 PF13499.6 KOO28644.1 - 0.057 13.9 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO28644.1 - 0.15 12.1 0.1 0.46 10.6 0.0 1.8 2 0 0 2 2 2 0 EF-hand domain HEAT_EZ PF13513.6 KOO28644.1 - 0.36 11.4 4.2 1.7 9.2 2.7 2.3 1 1 1 2 2 2 0 HEAT-like repeat PMSR PF01625.21 KOO28645.1 - 6.5e-09 36.1 0.0 1.1e-08 35.4 0.0 1.4 1 1 0 1 1 1 1 Peptide methionine sulfoxide reductase TPR_11 PF13414.6 KOO28645.1 - 0.0087 15.7 0.5 0.03 14.0 0.4 1.9 2 0 0 2 2 2 1 TPR repeat TPR_17 PF13431.6 KOO28645.1 - 0.022 15.1 0.1 0.21 12.0 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat MTS PF05175.14 KOO28645.1 - 0.3 10.6 0.7 0.61 9.6 0.3 1.7 2 0 0 2 2 2 0 Methyltransferase small domain SNARE_assoc PF09335.11 KOO28646.1 - 3.2e-06 27.6 3.2 1.3e-05 25.6 1.6 2.1 1 1 1 2 2 2 2 SNARE associated Golgi protein TPR_16 PF13432.6 KOO28648.1 - 1.8e-13 50.9 13.6 2.7e-08 34.3 3.9 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28648.1 - 5.8e-11 41.6 1.8 0.0037 17.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28648.1 - 1.1e-09 38.6 1.1 0.0003 21.2 0.1 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28648.1 - 2.6e-08 33.7 0.1 0.018 15.4 0.0 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28648.1 - 4.7e-08 33.2 10.5 0.00052 20.6 0.1 4.2 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28648.1 - 4.8e-07 29.3 0.0 0.0019 17.9 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28648.1 - 9.8e-07 28.4 1.0 0.0094 15.9 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28648.1 - 1.1e-06 28.4 0.0 0.002 18.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOO28648.1 - 2.5e-06 27.8 0.9 0.53 11.0 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28648.1 - 5e-06 26.1 0.0 0.018 14.7 0.0 3.2 1 1 2 3 3 3 3 TPR repeat TPR_12 PF13424.6 KOO28648.1 - 0.00018 21.7 3.4 0.52 10.6 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28648.1 - 0.00052 20.1 0.4 0.073 13.2 0.2 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO28648.1 - 2.4 9.0 12.8 10 7.1 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.17 KOO28648.1 - 3.5 8.1 11.4 0.56 10.6 2.4 3.0 2 1 1 3 3 3 0 Bacterial transcriptional activator domain ABC2_membrane PF01061.24 KOO28649.1 - 6.3e-24 84.6 7.7 6.3e-24 84.6 7.7 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_2 PF12679.7 KOO28649.1 - 0.012 14.9 4.4 0.023 14.0 4.4 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein DnaJ PF00226.31 KOO28650.1 - 8e-21 73.9 0.4 1.3e-20 73.2 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain Peptidase_S24 PF00717.23 KOO28650.1 - 6.3e-06 26.0 0.0 1.1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 KOO28650.1 - 0.0085 15.9 0.0 0.56 10.0 0.0 2.5 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 DUF5641 PF18701.1 KOO28650.1 - 0.04 14.1 0.0 0.099 12.8 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5641) SOR_SNZ PF01680.17 KOO28651.1 - 8.3e-98 326.2 4.0 1.3e-97 325.6 4.0 1.3 1 0 0 1 1 1 1 SOR/SNZ family SNO PF01174.19 KOO28651.1 - 2.3e-39 135.2 0.0 4.3e-39 134.3 0.0 1.4 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 KOO28651.1 - 2.6e-09 37.0 0.0 5.3e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain ThiG PF05690.14 KOO28651.1 - 1.3e-07 31.1 2.4 1.3e-06 28.0 0.0 2.3 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG NMO PF03060.15 KOO28651.1 - 0.00081 18.9 0.1 0.0018 17.8 0.1 1.5 1 0 0 1 1 1 1 Nitronate monooxygenase GATase PF00117.28 KOO28651.1 - 0.0022 17.8 0.0 0.0067 16.2 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I His_biosynth PF00977.21 KOO28651.1 - 0.0053 16.2 0.0 0.029 13.8 0.0 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein Milton PF12448.8 KOO28651.1 - 0.0064 16.6 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 Kinesin associated protein TetR_C_27 PF17935.1 KOO28651.1 - 0.08 13.0 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DJ-1_PfpI PF01965.24 KOO28651.1 - 0.087 12.6 0.0 0.27 11.0 0.0 1.8 1 0 0 1 1 1 0 DJ-1/PfpI family IGPS PF00218.21 KOO28651.1 - 0.18 10.9 0.0 0.59 9.2 0.0 1.8 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase TPR_8 PF13181.6 KOO28653.1 - 0.0031 17.6 0.0 4.9 7.6 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28653.1 - 0.0048 17.4 13.2 1.2 9.7 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28653.1 - 0.0099 15.9 7.8 21 5.5 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28653.1 - 0.073 12.8 0.0 3.9 7.2 0.0 3.2 3 0 0 3 3 3 0 TPR repeat TPR_17 PF13431.6 KOO28653.1 - 0.15 12.5 0.4 20 5.8 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28653.1 - 0.36 11.8 12.5 56 4.9 0.0 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat PKD_channel PF08016.12 KOO28655.1 - 3.9e-12 45.6 8.8 2.6e-10 39.6 0.1 2.1 2 0 0 2 2 2 2 Polycystin cation channel DUF1449 PF07290.11 KOO28655.1 - 0.21 11.2 2.6 0.58 9.8 2.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1449) ProQ PF04352.13 KOO28655.1 - 2 8.3 8.4 4.4 7.2 6.9 2.2 2 0 0 2 2 2 0 ProQ/FINO family Ion_trans PF00520.31 KOO28655.1 - 2.8 7.1 11.9 5.8 6.1 11.9 1.4 1 1 0 1 1 1 0 Ion transport protein Clathrin_lg_ch PF01086.17 KOO28656.1 - 1.9e-25 90.3 4.4 2.4e-25 90.0 4.4 1.1 1 0 0 1 1 1 1 Clathrin light chain Forkhead_N PF08430.12 KOO28656.1 - 0.051 14.2 17.5 0.082 13.5 17.5 1.4 1 0 0 1 1 1 0 Forkhead N-terminal region YscO-like PF16789.5 KOO28656.1 - 0.079 13.0 3.4 0.1 12.6 3.4 1.2 1 0 0 1 1 1 0 YscO-like protein HMG_box PF00505.19 KOO28658.1 - 8.6e-21 74.1 3.6 2.2e-20 72.8 3.6 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO28658.1 - 7.2e-13 48.9 4.9 7.6e-13 48.9 3.2 1.9 1 1 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 KOO28658.1 - 0.0013 18.7 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 CHDNT (NUC034) domain YABBY PF04690.13 KOO28658.1 - 0.097 13.2 0.7 0.15 12.6 0.7 1.5 1 1 0 1 1 1 0 YABBY protein DUF4407 PF14362.6 KOO28658.1 - 6.9 5.9 8.7 16 4.7 8.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Myb_DNA-binding PF00249.31 KOO28659.1 - 3.5e-36 123.1 5.4 6.7e-18 64.6 0.3 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO28659.1 - 9.1e-27 93.1 0.8 2.8e-14 53.1 0.0 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO28659.1 - 5e-06 26.3 0.0 5.8e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 KOO28659.1 - 0.017 15.5 1.5 6.7 7.2 0.3 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain SLIDE PF09111.10 KOO28659.1 - 0.022 14.8 0.0 1.7 8.7 0.0 2.2 1 1 1 2 2 2 0 SLIDE GA PF01468.17 KOO28659.1 - 0.028 14.7 1.7 0.94 9.8 0.4 2.4 2 0 0 2 2 2 0 GA module FUSC PF04632.12 KOO28659.1 - 0.81 8.1 7.6 1.5 7.2 7.6 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2057 PF09829.9 KOO28659.1 - 1.1 9.4 5.3 17 5.5 0.2 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) EF-hand_6 PF13405.6 KOO28660.1 - 6.8e-14 50.6 1.8 0.0019 18.0 0.1 4.0 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO28660.1 - 4.5e-12 46.3 0.2 3.2e-06 27.5 0.2 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO28660.1 - 2e-11 42.6 10.2 0.001 18.5 0.3 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO28660.1 - 1.5e-09 37.5 1.0 3.4e-08 33.2 0.6 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO28660.1 - 1.1e-07 31.1 7.2 0.056 13.0 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KOO28660.1 - 0.0087 16.4 0.1 5.5 7.4 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO28660.1 - 0.11 12.5 0.3 4.1 7.4 0.0 2.5 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand SKG6 PF08693.10 KOO28661.1 - 1.1e-06 27.9 1.9 1.1e-06 27.9 1.9 2.5 3 0 0 3 3 3 1 Transmembrane alpha-helix domain LAX PF15681.5 KOO28661.1 - 0.11 11.3 0.1 0.18 10.6 0.1 1.3 1 0 0 1 1 1 0 Lymphocyte activation family X Secretin PF00263.21 KOO28661.1 - 0.3 10.7 2.7 0.54 9.9 2.7 1.4 1 0 0 1 1 1 0 Bacterial type II and III secretion system protein Adeno_E3_CR2 PF02439.15 KOO28661.1 - 4.7 7.0 7.3 0.18 11.6 1.2 1.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 Lipase_GDSL_2 PF13472.6 KOO28662.1 - 0.0049 17.3 0.0 0.02 15.3 0.0 1.9 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Filamin PF00630.19 KOO28663.1 - 3.4e-25 88.8 0.0 5e-05 24.1 0.0 5.5 5 0 0 5 5 5 5 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO28663.1 - 0.017 15.4 0.0 3.3 8.1 0.0 3.7 4 0 0 4 4 4 0 Invasin, domain 3 PepSY_2 PF13670.6 KOO28663.1 - 1.6 8.8 4.4 22 5.2 0.0 2.8 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain ECH_1 PF00378.20 KOO28664.1 - 5.5e-38 130.7 0.0 9.3e-38 130.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOO28664.1 - 2.4e-34 119.3 0.1 2.9e-34 119.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Baculo_PEP_C PF04513.12 KOO28665.1 - 0.0002 21.4 2.0 1.1 9.3 0.0 4.1 3 1 1 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 KOO28665.1 - 0.00024 20.1 3.1 0.00024 20.1 3.1 3.7 1 1 3 4 4 4 1 Spc7 kinetochore protein DUF4515 PF14988.6 KOO28665.1 - 0.0069 16.3 1.2 0.0069 16.3 1.2 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4515) Halo_GVPC PF05465.13 KOO28665.1 - 0.0095 16.2 1.7 0.035 14.4 0.1 3.0 2 0 0 2 2 2 1 Halobacterial gas vesicle protein C (GVPC) repeat Fez1 PF06818.15 KOO28665.1 - 0.035 14.6 0.5 0.035 14.6 0.5 3.3 1 1 1 3 3 3 0 Fez1 CorA PF01544.18 KOO28665.1 - 0.42 9.9 13.0 0.23 10.8 2.0 2.9 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein Phage_GP20 PF06810.11 KOO28665.1 - 0.64 9.8 7.1 3.1 7.6 0.0 3.3 3 1 0 3 3 3 0 Phage minor structural protein GP20 Helo_like_N PF17111.5 KOO28665.1 - 3.8 6.8 6.9 5.1 6.4 0.0 3.6 4 0 0 4 4 4 0 Fungal N-terminal domain of STAND proteins ECM11 PF15463.6 KOO28665.1 - 5.4 7.6 14.0 3.9 8.1 0.1 4.6 3 1 2 5 5 5 0 Extracellular mutant protein 11 TPR_12 PF13424.6 KOO28667.1 - 5.5e-08 33.0 4.1 2.2e-07 31.0 4.1 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat EF-hand_6 PF13405.6 KOO28667.1 - 1.1e-05 24.9 0.0 0.1 12.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain TPR_10 PF13374.6 KOO28667.1 - 1.8e-05 24.5 3.8 0.002 17.9 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28667.1 - 1.9e-05 24.3 0.9 0.0047 16.7 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO28667.1 - 6e-05 22.9 3.3 0.016 15.3 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat EF-hand_1 PF00036.32 KOO28667.1 - 0.00018 20.8 0.1 0.42 10.3 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO28667.1 - 0.0015 19.0 0.0 0.0044 17.5 0.0 1.9 1 1 0 1 1 1 1 EF-hand domain pair TPR_16 PF13432.6 KOO28667.1 - 0.0023 18.6 1.8 0.0023 18.6 1.8 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat EF-hand_5 PF13202.6 KOO28667.1 - 0.01 15.3 0.0 1.3 8.6 0.0 2.4 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 KOO28667.1 - 0.041 13.7 0.1 0.44 10.4 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair TPR_8 PF13181.6 KOO28667.1 - 0.088 13.1 0.2 13 6.3 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANTH PF07651.16 KOO28670.1 - 2.3e-08 33.4 0.2 3.2e-08 32.9 0.2 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 KOO28670.1 - 8.5e-05 22.6 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 ENTH domain CTD PF12815.7 KOO28672.1 - 0.0072 16.9 45.9 0.019 15.5 5.4 5.2 1 1 2 3 3 3 1 Spt5 C-terminal nonapeptide repeat binding Spt4 LpxI_C PF06230.11 KOO28672.1 - 0.013 15.4 0.3 3.9 7.3 0.1 3.0 2 0 0 2 2 2 0 LpxI C-terminal domain DUF3640 PF12342.8 KOO28672.1 - 0.54 10.0 16.8 70 3.3 0.2 7.6 9 0 0 9 9 9 0 Protein of unknown function (DUF3640) Sel1 PF08238.12 KOO28673.1 - 1.4e-35 120.9 37.9 3.7e-07 30.6 0.7 7.6 7 0 0 7 7 7 6 Sel1 repeat U-box PF04564.15 KOO28673.1 - 2e-17 63.1 0.0 3.1e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO28673.1 - 0.00046 20.0 0.0 0.00097 18.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Erythro-docking PF09277.11 KOO28673.1 - 0.042 13.7 24.0 1.9 8.5 0.1 7.0 5 1 3 8 8 8 0 Erythronolide synthase, docking zf-NOSIP PF15906.5 KOO28673.1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TTL PF03133.15 KOO28674.1 - 5e-56 190.0 0.0 6.8e-56 189.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO28674.1 - 1.8e-06 27.4 0.0 0.00062 19.1 0.0 2.8 2 1 1 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO28674.1 - 1.5e-05 24.4 0.0 0.0074 15.6 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 KOO28674.1 - 0.16 12.0 0.0 0.36 10.9 0.0 1.5 2 0 0 2 2 2 0 ATP-grasp domain RabGAP-TBC PF00566.18 KOO28675.1 - 2.7e-15 56.6 0.0 3.4e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain MarC PF01914.17 KOO28675.1 - 0.18 11.1 0.1 0.31 10.4 0.1 1.3 1 0 0 1 1 1 0 MarC family integral membrane protein UreF PF01730.16 KOO28676.1 - 0.31 11.6 3.4 0.53 10.9 0.9 1.8 1 1 1 2 2 2 0 UreF RNase_PH PF01138.21 KOO28677.1 - 1.5e-22 80.5 0.0 1.8e-14 54.4 0.0 2.4 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOO28677.1 - 2.9e-08 33.6 0.1 7.6e-08 32.3 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 zf-CSL PF05207.13 KOO28678.1 - 2.7e-18 65.4 0.7 4e-18 64.9 0.7 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 KOO28678.1 - 0.0083 16.2 0.6 0.014 15.5 0.6 1.4 1 0 0 1 1 1 1 Zinc ribbon domain zinc_ribbon_5 PF13719.6 KOO28678.1 - 0.039 13.7 0.1 1.9 8.3 0.0 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.6 KOO28678.1 - 0.092 12.7 0.3 0.15 12.0 0.3 1.4 1 0 0 1 1 1 0 zinc-ribbon domain WW PF00397.26 KOO28679.1 - 7.1e-11 42.0 0.3 1.3e-10 41.2 0.3 1.4 1 0 0 1 1 1 1 WW domain PRCC PF10253.9 KOO28679.1 - 2.4 8.9 7.8 0.16 12.8 2.7 1.6 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting HycH PF07450.11 KOO28680.1 - 5 7.5 7.3 1.4 9.3 3.5 2.1 1 1 1 2 2 2 0 Formate hydrogenlyase maturation protein HycH Usp PF00582.26 KOO28681.1 - 0.055 14.0 0.1 0.068 13.7 0.1 1.4 1 1 0 1 1 1 0 Universal stress protein family TUDOR_5 PF18359.1 KOO28683.1 - 0.17 11.6 0.1 17 5.2 0.0 2.5 2 0 0 2 2 2 0 Histone methyltransferase Tudor domain 1 DnaJ PF00226.31 KOO28685.1 - 6.6e-22 77.4 0.9 1.1e-21 76.6 0.9 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.6 KOO28685.1 - 4.8e-08 32.7 0.0 1.7e-05 24.3 0.0 2.3 2 0 0 2 2 2 2 X-domain of DnaJ-containing Chromate_transp PF02417.15 KOO28688.1 - 5.5e-07 29.9 0.2 1.1e-06 28.9 0.2 1.4 1 1 0 1 1 1 1 Chromate transporter AAA_9 PF12781.7 KOO28688.1 - 0.76 8.9 2.0 1.2 8.2 2.0 1.3 1 0 0 1 1 1 0 ATP-binding dynein motor region HAUS6_N PF14661.6 KOO28688.1 - 4.6 6.8 8.2 7.7 6.0 8.2 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus LRR_8 PF13855.6 KOO28689.1 - 0.026 14.3 0.3 7.3 6.4 0.0 2.4 2 0 0 2 2 2 0 Leucine rich repeat LRR_6 PF13516.6 KOO28689.1 - 0.067 13.3 7.7 3 8.1 0.3 4.5 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 KOO28689.1 - 0.35 11.6 2.2 19 6.3 0.3 2.9 3 0 0 3 3 3 0 Leucine Rich Repeat Pkinase PF00069.25 KOO28691.1 - 1.7e-50 171.9 0.0 2.1e-50 171.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28691.1 - 2e-32 112.5 0.0 2.5e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO28691.1 - 1.3e-07 30.9 0.0 4.2e-07 29.2 0.0 1.7 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOO28691.1 - 2.9e-05 24.1 5.8 0.049 13.5 0.0 3.0 1 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO28691.1 - 0.0006 19.2 0.0 0.013 14.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO28691.1 - 0.00078 18.3 0.0 0.0017 17.2 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase ABC1 PF03109.16 KOO28691.1 - 0.058 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Seadorna_VP7 PF07387.11 KOO28691.1 - 0.075 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 DUF4407 PF14362.6 KOO28691.1 - 0.4 10.0 4.4 0.49 9.7 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pkinase PF00069.25 KOO28692.1 - 4.5e-52 177.0 0.4 6.3e-52 176.5 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28692.1 - 9.5e-33 113.6 0.1 1.5e-32 112.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO28692.1 - 0.00031 20.2 0.0 0.00041 19.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Csm1 PF12539.8 KOO28693.1 - 0.00068 20.2 0.0 0.0016 19.0 0.0 1.8 1 1 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 DUF5094 PF17015.5 KOO28693.1 - 0.02 15.0 0.0 0.11 12.6 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5094) THOC7 PF05615.13 KOO28693.1 - 0.024 14.9 2.6 0.04 14.2 2.6 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 Filament PF00038.21 KOO28693.1 - 0.04 13.5 0.6 0.066 12.8 0.6 1.4 1 0 0 1 1 1 0 Intermediate filament protein Spc24 PF08286.11 KOO28693.1 - 0.11 12.8 0.0 0.5 10.6 0.0 1.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF2285 PF10074.9 KOO28693.1 - 0.65 10.7 7.4 1.2 9.8 6.0 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2285) Ntox1 PF15500.6 KOO28693.1 - 0.86 10.0 4.7 9.6 6.6 4.7 2.4 1 1 0 1 1 1 0 Putative RNase-like toxin, toxin_1 DUF4140 PF13600.6 KOO28693.1 - 1.3 9.5 7.6 6.9 7.2 0.2 2.6 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) MscS_porin PF12795.7 KOO28693.1 - 1.5 8.3 12.7 2.5 7.6 2.2 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain LRR_6 PF13516.6 KOO28694.1 - 3.1e-25 86.0 46.2 0.016 15.2 0.0 17.3 16 0 0 16 16 16 7 Leucine Rich repeat LRR_1 PF00560.33 KOO28694.1 - 1.2e-15 55.6 4.1 33 5.6 0.0 12.1 13 0 0 13 13 12 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO28694.1 - 1.8e-10 40.4 7.6 11 5.9 0.0 11.6 13 1 0 13 13 13 1 Leucine rich repeat LRR_4 PF12799.7 KOO28694.1 - 1.5e-05 25.3 24.6 3.1 8.4 0.4 10.8 12 2 0 12 12 12 1 Leucine Rich repeats (2 copies) SIN1 PF05422.12 KOO28694.1 - 0.0099 16.4 0.0 40 4.7 0.0 3.2 3 0 0 3 3 3 0 Stress-activated map kinase interacting protein 1 (SIN1) DUF4112 PF13430.6 KOO28694.1 - 0.033 14.5 0.6 24 5.2 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4112) LRR_RI_capping PF18779.1 KOO28694.1 - 0.033 13.8 2.7 5.2 6.8 0.6 2.7 2 0 0 2 2 2 0 Capping Ribonuclease inhibitor Leucine Rich Repeat TA_inhibitor PF17574.2 KOO28694.1 - 0.037 14.1 8.1 35 4.5 0.1 6.1 6 0 0 6 6 6 0 Inhibitor of toxin/antitoxin system (Gp4.5) UPF0181 PF03701.14 KOO28694.1 - 0.037 13.7 12.1 32 4.3 0.0 7.1 8 0 0 8 8 8 0 Uncharacterised protein family (UPF0181) OAR PF03826.17 KOO28694.1 - 0.083 12.8 0.6 45 4.1 0.0 3.3 3 0 0 3 3 3 0 OAR domain SpoU_sub_bind PF08032.12 KOO28694.1 - 0.14 12.5 3.2 16 5.9 0.0 4.3 5 0 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding Aminotran_4 PF01063.19 KOO28695.1 - 5.3e-28 98.4 0.0 5.8e-28 98.3 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV Peptidase_S9 PF00326.21 KOO28696.1 - 1.3e-37 129.3 0.0 4.3e-37 127.6 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 KOO28696.1 - 1.6e-10 40.4 0.0 7e-07 28.4 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Acetyltransf_1 PF00583.25 KOO28696.1 - 3.6e-10 40.1 0.0 9.6e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOO28696.1 - 2.1e-07 30.9 0.0 7.7e-07 29.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOO28696.1 - 3e-06 27.5 0.0 1.1e-05 25.8 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO28696.1 - 6.4e-06 26.0 0.0 1.4e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 KOO28696.1 - 0.001 19.1 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 KOO28696.1 - 0.06 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Clathrin_propel PF01394.20 KOO28698.1 - 4.5e-41 137.2 3.1 2.8e-07 30.5 0.0 6.3 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 KOO28698.1 - 2.1e-29 101.2 0.2 4.9e-29 100.0 0.2 1.7 1 0 0 1 1 1 1 Clathrin-H-link Clathrin-link PF09268.10 KOO28698.1 - 6.2e-08 31.9 0.4 1.3e-07 30.9 0.0 1.8 2 0 0 2 2 2 1 Clathrin, heavy-chain linker Clathrin PF00637.20 KOO28698.1 - 0.12 12.2 0.0 2.4 8.0 0.0 2.8 3 0 0 3 3 3 0 Region in Clathrin and VPS Lactonase PF10282.9 KOO28699.1 - 0.00021 20.6 0.0 0.083 12.1 0.0 2.4 2 0 0 2 2 2 2 Lactonase, 7-bladed beta-propeller WD40 PF00400.32 KOO28700.1 - 4.8e-38 128.5 9.2 5.1e-09 36.6 0.3 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat HEM4 PF02602.15 KOO28700.1 - 1.1e-17 64.2 1.3 1.8e-17 63.5 1.3 1.4 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Ge1_WD40 PF16529.5 KOO28700.1 - 1e-10 41.1 2.9 0.018 14.0 0.1 4.2 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO28700.1 - 9.2e-10 38.7 0.3 0.17 12.2 0.0 4.3 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO28700.1 - 7.8e-09 35.2 0.2 0.67 10.0 0.0 4.4 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO28700.1 - 0.00026 19.5 0.0 0.14 10.4 0.0 2.8 1 1 2 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 KOO28700.1 - 0.0058 16.0 0.0 0.13 11.5 0.0 2.3 1 1 0 2 2 2 1 WD40-like domain DUF1513 PF07433.11 KOO28700.1 - 0.022 13.9 0.0 0.064 12.3 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1513) Cpn60_TCP1 PF00118.24 KOO28701.1 - 2.7e-93 313.3 17.6 7.3e-93 311.8 17.6 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family DOT1 PF08123.13 KOO28701.1 - 0.015 14.8 0.1 0.032 13.8 0.1 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 MFS_1 PF07690.16 KOO28702.1 - 9.3e-23 80.7 25.0 2e-22 79.6 25.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily EF-hand_5 PF13202.6 KOO28702.1 - 9.9e-10 37.5 2.3 0.00064 19.1 0.3 2.3 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO28702.1 - 9.5e-09 34.2 0.8 0.0046 16.4 0.5 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO28702.1 - 2.3e-08 33.3 0.2 0.0065 16.3 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO28702.1 - 2.9e-08 34.0 0.2 4.8e-08 33.3 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO28702.1 - 5.8e-08 32.5 0.1 0.0047 16.8 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair Sugar_tr PF00083.24 KOO28702.1 - 7.7e-08 31.6 7.2 7.7e-08 31.6 7.2 1.9 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 KOO28702.1 - 0.00057 18.4 9.3 0.00057 18.4 9.3 2.1 1 1 1 2 2 2 1 Transmembrane secretion effector MFS_1_like PF12832.7 KOO28702.1 - 0.0094 14.8 1.5 0.013 14.4 1.5 1.2 1 0 0 1 1 1 1 MFS_1 like family OATP PF03137.20 KOO28702.1 - 0.017 13.4 1.2 2.6 6.2 0.0 2.1 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family FKBP_C PF00254.28 KOO28703.1 - 1.6e-19 70.0 0.0 2.5e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 KOO28703.1 - 9.5e-09 36.1 0.0 3.2e-08 34.4 0.0 1.9 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Arm PF00514.23 KOO28704.1 - 2.1e-17 62.5 8.2 0.00011 22.1 0.1 5.7 5 1 0 5 5 5 4 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO28704.1 - 0.055 13.5 0.0 0.78 9.8 0.0 2.5 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain MFS_1 PF07690.16 KOO28706.1 - 1e-16 60.9 27.8 1e-16 60.9 27.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KOO28706.1 - 0.26 9.6 4.8 1 7.6 4.8 1.9 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family zf-H2C2_2 PF13465.6 KOO28709.1 - 2.9e-17 62.2 12.9 1e-05 25.7 0.2 3.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 KOO28709.1 - 6.2e-17 61.0 23.6 0.0001 22.5 0.4 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOO28709.1 - 1.3e-08 35.0 22.4 0.011 16.5 1.2 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOO28709.1 - 0.0072 16.3 7.1 0.37 10.9 0.2 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KOO28709.1 - 0.021 15.1 1.9 1.4 9.2 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 KOO28709.1 - 0.026 15.2 15.3 1.5 9.5 0.5 3.4 3 0 0 3 3 3 0 FOXP coiled-coil domain zf-TRAF PF02176.18 KOO28709.1 - 0.87 10.3 8.8 12 6.7 0.1 3.0 1 1 2 3 3 3 0 TRAF-type zinc finger zf-C2H2_aberr PF17017.5 KOO28709.1 - 0.93 9.6 4.8 3.3 7.8 0.4 2.8 2 1 1 3 3 3 0 Aberrant zinc-finger zf-C2H2_11 PF16622.5 KOO28709.1 - 7.2 6.5 7.1 3.7 7.4 1.8 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type GCP_N_terminal PF17681.1 KOO28710.1 - 2.3e-37 129.3 0.0 5.4e-36 124.8 0.0 2.0 1 1 2 3 3 3 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 KOO28710.1 - 4.2e-32 111.9 4.3 7.3e-32 111.1 4.3 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal SHIPPO-rpt PF07004.12 KOO28711.1 - 3.4e-14 53.0 32.2 0.022 15.7 0.3 8.9 9 0 0 9 9 9 8 Sperm-tail PG-rich repeat CPSF_A PF03178.15 KOO28712.1 - 7e-54 183.3 0.0 8.5e-54 183.0 0.0 1.1 1 0 0 1 1 1 1 CPSF A subunit region RNA_pol_L_2 PF13656.6 KOO28713.1 - 2.6e-24 84.8 0.0 3.5e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KOO28713.1 - 5.5e-05 22.5 0.0 8.6e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Rio2_N PF09202.11 KOO28713.1 - 0.073 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Rio2, N-terminal LeuA_dimer PF08502.10 KOO28713.1 - 0.14 12.1 0.0 0.14 12.0 0.0 1.4 1 1 0 1 1 1 0 LeuA allosteric (dimerisation) domain Pkinase PF00069.25 KOO28714.1 - 3.3e-65 220.1 0.0 3.8e-65 219.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28714.1 - 3.6e-38 131.3 0.0 4.9e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO28714.1 - 3.4e-05 23.3 0.1 5.1e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO28714.1 - 0.00053 18.9 0.0 0.00074 18.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO28714.1 - 0.023 14.6 0.0 0.43 10.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO28714.1 - 0.029 13.7 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 KOO28714.1 - 0.039 12.9 0.0 0.055 12.4 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Ank_4 PF13637.6 KOO28716.1 - 4.4e-16 59.0 0.8 1.1e-05 25.9 0.0 5.6 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO28716.1 - 1.2e-14 54.1 2.1 0.0055 17.0 0.0 6.0 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO28716.1 - 1.1e-10 41.9 0.0 0.00024 21.6 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO28716.1 - 1.9e-10 40.0 0.7 0.46 11.2 0.0 6.2 6 0 0 6 6 5 3 Ankyrin repeat TPR_2 PF07719.17 KOO28716.1 - 1.5e-09 37.2 7.5 0.12 12.5 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat zf-C3HC4_3 PF13920.6 KOO28716.1 - 4.2e-08 32.9 12.3 7.8e-08 32.1 12.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TPR_16 PF13432.6 KOO28716.1 - 7e-07 29.8 18.5 0.0012 19.5 9.2 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO28716.1 - 1.6e-05 24.7 0.7 11 6.6 0.0 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO28716.1 - 5e-05 23.4 0.9 0.25 11.8 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28716.1 - 0.0001 22.5 10.1 0.036 14.4 0.2 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28716.1 - 0.00018 21.1 4.5 0.13 12.1 0.1 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28716.1 - 0.00019 21.9 10.9 0.11 13.0 5.3 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28716.1 - 0.00077 19.1 1.0 1.8 8.3 0.0 4.3 3 1 1 4 4 4 1 TPR repeat TPR_14 PF13428.6 KOO28716.1 - 0.0071 17.1 16.6 2.6 9.1 2.1 5.5 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28716.1 - 0.022 14.8 1.0 1.3 9.2 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat Ank PF00023.30 KOO28716.1 - 0.041 14.3 0.7 20 5.8 0.0 4.7 5 0 0 5 5 5 0 Ankyrin repeat TPR_10 PF13374.6 KOO28716.1 - 0.067 13.1 0.4 0.067 13.1 0.4 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO28716.1 - 1.4 9.7 8.0 53 4.8 0.9 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28716.1 - 3.7 7.8 10.2 4.7 7.4 0.2 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat Thioredoxin PF00085.20 KOO28717.1 - 1.5e-25 89.2 0.0 3e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KOO28717.1 - 0.0029 17.9 0.0 0.54 10.6 0.0 2.5 1 1 1 2 2 2 1 Thioredoxin-like Glutaredoxin PF00462.24 KOO28717.1 - 0.017 15.3 0.2 5.7 7.2 0.0 3.8 4 0 0 4 4 4 0 Glutaredoxin TraF PF13728.6 KOO28717.1 - 0.026 14.4 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 KOO28717.1 - 0.042 14.0 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_2 PF13098.6 KOO28717.1 - 0.077 13.4 0.1 0.36 11.3 0.1 2.2 2 1 0 2 2 2 0 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KOO28717.1 - 0.18 11.6 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_3 PF13192.6 KOO28717.1 - 0.21 11.7 0.0 0.43 10.7 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain DUF3293 PF11697.8 KOO28718.1 - 9.6e-16 58.0 0.6 2.6e-15 56.6 0.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3293) ATG_C PF09333.11 KOO28721.1 - 0.015 15.7 0.2 5.3 7.5 0.1 3.3 1 1 1 2 2 2 0 Autophagy-related protein C terminal domain DUF760 PF05542.11 KOO28721.1 - 0.037 14.4 0.1 0.18 12.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF760) SMBP PF16785.5 KOO28721.1 - 0.08 13.2 0.1 0.08 13.2 0.1 2.4 2 0 0 2 2 2 0 Small metal-binding protein YtxH PF12732.7 KOO28721.1 - 0.11 13.1 3.4 1.3 9.7 3.3 2.3 1 1 0 1 1 1 0 YtxH-like protein Spc7 PF08317.11 KOO28721.1 - 2.5 6.9 7.6 4.8 6.0 7.6 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Trm112p PF03966.16 KOO28723.1 - 9.5e-15 54.9 0.0 1.2e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein Glyco_transf_20 PF00982.21 KOO28725.1 - 4.7e-98 328.9 0.0 5.8e-98 328.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOO28725.1 - 6.2e-31 107.3 0.0 5.7e-30 104.2 0.0 2.1 1 1 0 1 1 1 1 Trehalose-phosphatase CBM_20 PF00686.19 KOO28725.1 - 1.2e-16 60.4 0.0 3.6e-16 58.8 0.0 1.8 2 0 0 2 2 2 1 Starch binding domain O-FucT PF10250.9 KOO28727.1 - 1.3e-05 25.1 0.0 0.058 13.1 0.0 2.2 2 0 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase Helicase_C PF00271.31 KOO28728.1 - 6.2e-17 61.9 0.0 3.9e-16 59.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO28728.1 - 5.6e-16 58.8 0.0 9.4e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase RQC PF09382.10 KOO28728.1 - 5.3e-14 52.0 0.0 3e-13 49.5 0.0 2.3 3 0 0 3 3 3 1 RQC domain HRDC PF00570.23 KOO28728.1 - 2.5e-12 46.6 0.0 5.1e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 HRDC domain RecQ_Zn_bind PF16124.5 KOO28728.1 - 5.5e-12 46.2 1.3 5.5e-12 46.2 1.3 2.4 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 KOO28728.1 - 0.00063 19.8 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Phosphoesterase PF04185.14 KOO28730.1 - 2.5e-52 178.2 0.3 1.4e-48 165.9 0.2 2.1 1 1 0 2 2 2 2 Phosphoesterase family LRR_6 PF13516.6 KOO28731.1 - 1.2e-09 37.4 8.4 0.0056 16.6 0.1 7.4 9 0 0 9 9 9 3 Leucine Rich repeat LRR_4 PF12799.7 KOO28731.1 - 2.2e-06 27.9 0.3 0.021 15.3 0.0 4.8 4 1 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO28731.1 - 0.0013 18.4 0.4 6.9 6.5 0.0 4.2 3 1 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 KOO28731.1 - 1.4 9.8 7.8 18 6.3 0.0 5.2 6 0 0 6 6 6 0 Leucine Rich Repeat Glyco_trans_1_4 PF13692.6 KOO28732.1 - 1.6e-09 38.3 0.0 4.7e-09 36.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 TetR_C_22 PF17928.1 KOO28732.1 - 0.45 10.8 4.4 8.2 6.8 0.2 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Ank_3 PF13606.6 KOO28733.1 - 0.0026 18.1 0.4 0.47 11.2 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeat Methyltransf_25 PF13649.6 KOO28733.1 - 0.0075 16.9 0.0 0.015 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ank_2 PF12796.7 KOO28733.1 - 0.016 15.8 0.0 0.027 15.1 0.0 1.3 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank PF00023.30 KOO28733.1 - 0.058 13.9 0.2 0.32 11.5 0.1 2.2 2 0 0 2 2 2 0 Ankyrin repeat Methyltransf_11 PF08241.12 KOO28733.1 - 0.11 13.2 0.0 0.21 12.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ADH_zinc_N_2 PF13602.6 KOO28734.1 - 3.8e-15 57.1 0.0 1.5e-14 55.2 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOO28734.1 - 2.1e-13 50.4 0.0 3.9e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOO28734.1 - 3.7e-09 36.4 0.0 1.1e-08 35.0 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain LDcluster4 PF18306.1 KOO28734.1 - 0.0042 16.7 0.6 0.0078 15.8 0.6 1.4 1 0 0 1 1 1 1 SLOG cluster4 family TOBE PF03459.17 KOO28734.1 - 0.046 14.0 0.1 0.11 12.8 0.1 1.6 1 0 0 1 1 1 0 TOBE domain ADH_N_2 PF16884.5 KOO28734.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase LRR_4 PF12799.7 KOO28735.1 - 2.1e-05 24.8 4.5 14 6.3 0.1 6.7 5 3 5 10 10 10 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO28735.1 - 0.0012 18.7 0.3 7 7.0 0.1 5.4 5 0 0 5 5 5 1 Leucine Rich repeat LRR_1 PF00560.33 KOO28735.1 - 6.3 7.8 5.4 17 6.5 0.0 4.5 8 0 0 8 8 8 0 Leucine Rich Repeat HA2 PF04408.23 KOO28736.1 - 9.9e-16 58.0 0.0 2.1e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KOO28736.1 - 1.9e-13 50.7 0.0 4.6e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 KOO28736.1 - 6.4e-07 29.7 0.0 1.1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KOO28736.1 - 0.036 13.8 0.2 0.064 13.0 0.2 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase SMN PF06003.12 KOO28736.1 - 0.063 12.5 0.7 0.13 11.5 0.7 1.5 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF4537 PF15057.6 KOO28736.1 - 0.065 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) DUF4558 PF15104.6 KOO28736.1 - 0.11 12.5 0.2 0.11 12.5 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) Rrp44_CSD1 PF17216.3 KOO28736.1 - 0.16 11.7 0.3 0.29 10.8 0.3 1.3 1 0 0 1 1 1 0 Rrp44-like cold shock domain Response_reg PF00072.24 KOO28737.1 - 3e-20 72.4 0.2 3.8e-20 72.1 0.2 1.1 1 0 0 1 1 1 1 Response regulator receiver domain RCC1 PF00415.18 KOO28739.1 - 1.4e-41 140.9 5.7 4e-12 46.6 0.1 4.7 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO28739.1 - 4.7e-28 96.4 12.6 3.9e-09 36.1 0.2 4.5 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat DUF724 PF05266.14 KOO28739.1 - 0.02 14.7 14.5 0.089 12.6 4.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF724) TMF_TATA_bd PF12325.8 KOO28739.1 - 0.038 14.2 22.0 0.31 11.3 0.3 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Golgin_A5 PF09787.9 KOO28739.1 - 0.12 11.8 19.7 1 8.7 7.6 3.3 3 0 0 3 3 3 0 Golgin subfamily A member 5 DUF3037 PF11236.8 KOO28739.1 - 0.36 11.3 0.1 0.36 11.3 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3037) DUF3450 PF11932.8 KOO28739.1 - 1.6 8.0 16.3 8.3 5.6 9.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) KinB_sensor PF16767.5 KOO28739.1 - 1.8 9.0 9.6 0.11 13.0 3.1 2.3 3 0 0 3 3 3 0 Sensor domain of alginate biosynthesis sensor protein KinB APG6_N PF17675.1 KOO28739.1 - 4.3 7.9 30.8 11 6.6 19.3 3.6 2 1 1 3 3 3 0 Apg6 coiled-coil region DUF2240 PF09999.9 KOO28740.1 - 0.0089 15.7 1.2 0.01 15.5 1.2 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2240) CALM_bind PF16025.5 KOO28740.1 - 0.19 12.2 3.1 0.23 12.0 3.1 1.1 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding SLT_L PF14718.6 KOO28740.1 - 0.33 11.1 7.4 0.46 10.7 7.4 1.2 1 0 0 1 1 1 0 Soluble lytic murein transglycosylase L domain RraA-like PF03737.15 KOO28741.1 - 1.1e-29 103.5 0.0 1.6e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 Aldolase/RraA Rep_fac_C PF08542.11 KOO28742.1 - 5.9e-22 77.9 0.0 2.7e-21 75.8 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 KOO28742.1 - 1.1e-14 55.0 0.1 1.7e-14 54.4 0.1 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 KOO28742.1 - 8.1e-11 42.0 0.0 3.4e-09 36.7 0.1 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 KOO28742.1 - 1.5e-06 28.7 0.2 0.00018 21.9 0.0 2.6 1 1 2 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 KOO28742.1 - 2.4e-05 24.4 0.0 3.5e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 KOO28742.1 - 3.4e-05 23.8 0.0 0.00011 22.2 0.0 1.7 1 1 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 KOO28742.1 - 7e-05 23.1 0.2 0.049 13.9 0.1 2.4 1 1 1 2 2 2 2 AAA domain Mg_chelatase PF01078.21 KOO28742.1 - 7.9e-05 22.1 0.1 0.00083 18.8 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 KOO28742.1 - 0.00025 20.7 0.4 0.0025 17.4 0.1 2.4 2 1 1 3 3 3 1 AAA domain TniB PF05621.11 KOO28742.1 - 0.00048 19.6 0.0 0.7 9.3 0.0 2.5 2 0 0 2 2 2 2 Bacterial TniB protein AAA_24 PF13479.6 KOO28742.1 - 0.00064 19.5 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO28742.1 - 0.00064 19.7 0.1 0.002 18.1 0.0 1.9 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOO28742.1 - 0.00089 19.0 0.0 0.0024 17.7 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 KOO28742.1 - 0.00093 19.0 0.0 0.0015 18.4 0.0 1.3 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOO28742.1 - 0.0017 18.1 0.0 0.0031 17.3 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 KOO28742.1 - 0.0038 17.0 0.4 0.0099 15.6 0.4 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOO28742.1 - 0.0062 16.8 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO28742.1 - 0.0072 16.9 0.0 0.013 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO28742.1 - 0.01 16.2 1.0 0.034 14.5 1.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOO28742.1 - 0.016 14.7 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 KOO28742.1 - 0.019 14.8 0.0 0.037 13.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_assoc_2 PF16193.5 KOO28742.1 - 0.025 14.9 0.0 0.083 13.2 0.0 2.0 1 0 0 1 1 1 0 AAA C-terminal domain DEAD PF00270.29 KOO28742.1 - 0.031 14.0 0.2 1.1 9.0 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase RNA_helicase PF00910.22 KOO28742.1 - 0.034 14.5 0.0 0.14 12.6 0.0 1.9 1 1 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 KOO28742.1 - 0.037 13.7 0.1 0.089 12.5 0.1 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.20 KOO28742.1 - 0.045 12.8 0.0 0.075 12.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein MipZ PF09140.11 KOO28742.1 - 0.051 12.9 0.0 0.089 12.1 0.0 1.3 1 0 0 1 1 1 0 ATPase MipZ NTPase_1 PF03266.15 KOO28742.1 - 0.084 12.8 0.6 0.4 10.6 0.1 2.1 1 1 0 2 2 2 0 NTPase ResIII PF04851.15 KOO28742.1 - 0.13 12.2 0.0 14 5.7 0.0 2.3 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit MeaB PF03308.16 KOO28742.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 KOO28742.1 - 0.15 11.8 0.0 0.39 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DNA_pol3_delta PF06144.13 KOO28742.1 - 0.16 11.7 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit DUF2075 PF09848.9 KOO28742.1 - 0.24 10.6 0.4 7.6 5.7 0.4 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 KOO28742.1 - 0.27 10.7 1.0 6.9 6.1 0.1 2.2 1 1 0 2 2 2 0 PhoH-like protein GIT_CC PF16559.5 KOO28743.1 - 0.0016 18.2 4.4 0.042 13.7 0.3 3.2 3 0 0 3 3 3 1 GIT coiled-coil Rho guanine nucleotide exchange factor KASH_CCD PF14662.6 KOO28743.1 - 0.18 11.6 10.1 0.02 14.7 4.3 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Sipho_Gp157 PF05565.11 KOO28743.1 - 0.2 11.7 2.7 0.53 10.3 2.4 1.9 1 1 0 1 1 1 0 Siphovirus Gp157 OmpH PF03938.14 KOO28743.1 - 0.49 10.7 11.6 0.36 11.1 0.8 2.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) YabA PF06156.13 KOO28743.1 - 0.51 11.0 4.3 5 7.8 0.6 2.8 1 1 1 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 KOO28743.1 - 0.53 9.6 19.7 0.27 10.5 5.3 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) SMC_ScpA PF02616.14 KOO28743.1 - 0.93 9.3 6.9 1.5 8.7 6.9 1.3 1 0 0 1 1 1 0 Segregation and condensation protein ScpA V_ATPase_I PF01496.19 KOO28743.1 - 1.1 7.1 5.9 1.1 7.1 5.5 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family TolA_bind_tri PF16331.5 KOO28743.1 - 1.4 9.0 11.2 13 5.9 0.1 3.6 1 1 2 3 3 3 0 TolA binding protein trimerisation Spc7 PF08317.11 KOO28743.1 - 2.1 7.1 14.7 6.3 5.6 1.4 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein bZIP_1 PF00170.21 KOO28743.1 - 6.1 7.0 13.5 4.3 7.5 0.5 3.9 5 0 0 5 5 5 0 bZIP transcription factor DUF724 PF05266.14 KOO28743.1 - 7.5 6.3 8.4 1.7 8.4 0.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DREV PF05219.12 KOO28745.1 - 1e-24 87.1 0.0 1.7e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_12 PF08242.12 KOO28745.1 - 2e-10 41.3 0.0 3.9e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO28745.1 - 1.3e-09 38.5 0.0 2.8e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO28745.1 - 2e-09 37.5 0.0 3.3e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO28745.1 - 2.1e-05 25.1 0.0 4.7e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO28745.1 - 0.0037 17.1 0.0 0.087 12.6 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 KOO28745.1 - 0.059 12.3 0.0 0.087 11.7 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) Arf PF00025.21 KOO28747.1 - 5.3e-56 188.8 0.0 6.7e-56 188.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOO28747.1 - 3.1e-14 53.2 0.0 4.5e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO28747.1 - 6.9e-12 45.3 0.0 8.4e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KOO28747.1 - 1.4e-10 40.9 0.1 4.5e-07 29.4 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 KOO28747.1 - 1.6e-09 37.4 0.0 2.2e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOO28747.1 - 4.5e-06 26.2 0.0 6.3e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO28747.1 - 4.6e-05 23.5 0.0 8.5e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KOO28747.1 - 0.00013 22.4 2.5 0.0016 18.9 0.0 2.4 2 1 0 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 KOO28747.1 - 0.0012 19.4 0.1 0.005 17.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 KOO28747.1 - 0.002 18.1 0.4 0.02 14.8 0.4 2.3 1 1 0 1 1 1 1 NACHT domain RsgA_GTPase PF03193.16 KOO28747.1 - 0.0027 17.6 0.0 0.81 9.6 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 KOO28747.1 - 0.016 14.8 0.0 3.3 7.3 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 KOO28747.1 - 0.018 15.2 0.1 0.084 13.0 0.0 2.1 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.15 KOO28747.1 - 0.035 14.0 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 KOO28747.1 - 0.039 14.2 0.0 0.065 13.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.9 KOO28747.1 - 0.046 12.9 0.0 0.066 12.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 PduV-EutP PF10662.9 KOO28747.1 - 0.065 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KOO28747.1 - 0.078 12.5 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 KOO28747.1 - 0.11 12.5 0.0 1.4 9.0 0.0 2.1 1 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KOO28747.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 NTPase SRP54 PF00448.22 KOO28747.1 - 0.2 11.3 0.0 0.36 10.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RecO_N PF11967.8 KOO28748.1 - 0.055 13.5 0.0 0.098 12.6 0.0 1.4 1 0 0 1 1 1 0 Recombination protein O N terminal COX7a PF02238.15 KOO28748.1 - 0.28 11.6 1.8 0.68 10.4 1.8 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII RVT_2 PF07727.14 KOO28749.1 - 2.6e-25 89.5 0.0 4.4e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ank_2 PF12796.7 KOO28750.1 - 0.012 16.2 0.0 0.024 15.2 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO28750.1 - 0.031 14.9 0.0 0.063 13.9 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO28750.1 - 0.13 12.7 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) eIF3_subunit PF08597.10 KOO28750.1 - 0.59 10.0 6.5 0.067 13.1 1.6 1.8 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit DUF1387 PF07139.11 KOO28750.1 - 1.9 8.1 6.5 5.6 6.6 6.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1387) SAP PF02037.27 KOO28751.1 - 5.4e-15 54.8 0.0 4.9e-07 29.4 0.2 2.5 2 0 0 2 2 2 2 SAP domain Dscam_C PF12355.8 KOO28751.1 - 0.57 11.2 2.7 1 10.3 2.7 1.5 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal PsbW PF07123.12 KOO28752.1 - 2.4e-05 24.3 1.7 4.5e-05 23.5 1.6 1.7 1 1 0 1 1 1 1 Photosystem II reaction centre W protein (PsbW) Aldedh PF00171.22 KOO28753.1 - 2.9e-102 342.6 0.1 4.7e-68 229.8 0.1 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family DUF1995 PF09353.10 KOO28754.1 - 4.6e-13 49.7 0.0 6.3e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) LamB_YcsF PF03746.16 KOO28755.1 - 0.082 12.6 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 LamB/YcsF family Ribosomal_L37e PF01907.19 KOO28756.1 - 4.1e-21 74.9 7.7 7.6e-21 74.0 7.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e SelR PF01641.18 KOO28756.1 - 0.0022 18.1 0.2 0.0026 17.8 0.2 1.2 1 0 0 1 1 1 1 SelR domain DZR PF12773.7 KOO28756.1 - 0.014 15.4 1.6 0.023 14.7 1.6 1.3 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 KOO28756.1 - 0.043 13.5 1.0 7.4 6.4 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 KOO28756.1 - 0.061 13.3 1.1 0.078 13.0 1.1 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rubredoxin_2 PF18073.1 KOO28756.1 - 0.19 11.5 4.4 1.7 8.5 0.3 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain DUF35_N PF12172.8 KOO28756.1 - 0.2 11.6 3.9 0.37 10.7 3.9 1.4 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zn-ribbon_14 PF16503.5 KOO28756.1 - 0.49 9.9 3.9 4.6 6.8 0.3 2.2 2 0 0 2 2 2 0 Zinc-ribbon DUF2688 PF10892.8 KOO28756.1 - 0.61 9.6 5.6 0.72 9.4 2.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) Chloroa_b-bind PF00504.21 KOO28757.1 - 4.6e-29 102.0 0.1 5.9e-29 101.7 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Calpain_III PF01067.22 KOO28760.1 - 1.9e-17 63.8 0.0 9.6e-06 25.9 0.0 5.4 4 1 0 4 4 4 4 Calpain large subunit, domain III EF-hand_1 PF00036.32 KOO28760.1 - 5.2e-05 22.5 0.0 0.48 10.1 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO28760.1 - 0.05 14.0 0.0 7.4 7.1 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair Topoisom_I PF01028.20 KOO28761.1 - 7e-88 293.8 5.4 1.2e-87 293.0 5.4 1.4 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 KOO28761.1 - 3.2e-82 275.2 3.0 3.2e-82 275.2 3.0 2.3 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 KOO28761.1 - 2.5e-30 104.2 0.4 7.8e-30 102.6 0.4 1.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain DUF4407 PF14362.6 KOO28761.1 - 0.023 14.1 9.2 0.037 13.4 4.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 KOO28761.1 - 0.19 11.8 6.0 0.06 13.4 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) RecG_N PF17190.4 KOO28761.1 - 2.7 8.8 8.1 36 5.2 0.0 3.5 3 0 0 3 3 3 0 RecG N-terminal helical domain Ion_trans PF00520.31 KOO28762.1 - 3.4e-21 75.6 10.4 3.4e-21 75.6 10.4 2.0 3 0 0 3 3 3 1 Ion transport protein Ion_trans_2 PF07885.16 KOO28762.1 - 2.7e-09 36.9 9.9 2.7e-09 36.9 9.9 2.7 2 1 0 2 2 2 1 Ion channel cNMP_binding PF00027.29 KOO28762.1 - 2.3e-07 30.8 0.0 4.4e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain APG6_N PF17675.1 KOO28762.1 - 0.49 10.9 11.9 0.18 12.3 1.4 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 KOO28762.1 - 4 7.7 7.5 2.8 8.2 1.0 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ATP-grasp_2 PF08442.10 KOO28763.1 - 3.5e-64 216.1 2.1 5.1e-64 215.6 2.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 KOO28763.1 - 1.1e-25 90.2 1.4 5e-25 88.1 1.5 2.1 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 KOO28763.1 - 2.7e-09 36.8 0.6 5.2e-09 35.9 0.6 1.3 1 0 0 1 1 1 1 ATP-grasp domain RRM_1 PF00076.22 KOO28764.1 - 3.6e-14 52.3 0.1 5.8e-14 51.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.27 KOO28764.1 - 6.6e-09 35.3 0.1 1.1e-08 34.7 0.1 1.3 1 0 0 1 1 1 1 SAP domain LRR_6 PF13516.6 KOO28765.1 - 1.6e-42 139.9 21.1 1.2e-05 25.0 0.2 8.2 8 0 0 8 8 8 8 Leucine Rich repeat LRR_4 PF12799.7 KOO28765.1 - 7.5e-08 32.6 5.2 0.22 12.0 0.2 5.6 4 3 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO28765.1 - 4.3e-05 23.5 0.0 19 6.3 0.0 6.2 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO28765.1 - 0.00042 20.0 2.2 7.5 6.4 0.0 5.7 6 1 0 6 6 6 1 Leucine rich repeat Lipocalin_3 PF12702.7 KOO28765.1 - 0.012 15.7 0.2 5.8 7.1 0.0 3.7 2 2 2 4 4 4 0 Lipocalin-like SpoU_sub_bind PF08032.12 KOO28765.1 - 0.049 13.9 5.4 6.6 7.1 0.1 4.2 2 2 4 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding CbiG_N PF11760.8 KOO28765.1 - 0.18 11.9 23.3 3 7.9 0.1 6.0 4 2 1 5 5 5 0 Cobalamin synthesis G N-terminal Arm-DNA-bind_1 PF09003.10 KOO28765.1 - 4.7 7.4 16.2 8.1 6.7 0.2 5.3 4 3 3 7 7 7 0 Bacteriophage lambda integrase, Arm DNA-binding domain AAA_12 PF13087.6 KOO28767.1 - 3.6e-46 157.3 0.0 5.3e-46 156.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO28767.1 - 5.8e-17 62.3 1.0 9.6e-17 61.6 0.3 1.7 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 KOO28767.1 - 5e-07 29.7 0.0 0.03 14.1 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 KOO28767.1 - 2.1e-05 24.3 0.0 0.00015 21.5 0.0 2.3 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 KOO28767.1 - 0.00036 20.9 0.0 0.53 10.6 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 KOO28767.1 - 0.0024 17.6 2.2 0.041 13.6 0.1 2.8 2 2 1 3 3 3 1 AAA domain HSP70 PF00012.20 KOO28768.1 - 0.16 10.1 0.0 0.23 9.6 0.0 1.1 1 0 0 1 1 1 0 Hsp70 protein Complex1_30kDa PF00329.19 KOO28768.1 - 0.17 12.5 0.0 0.27 11.9 0.0 1.3 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Sigma70_ner PF04546.13 KOO28769.1 - 0.0024 17.8 0.6 0.0038 17.1 0.6 1.2 1 0 0 1 1 1 1 Sigma-70, non-essential region GTP1_OBG PF01018.22 KOO28769.1 - 0.048 13.2 0.4 0.12 11.9 0.3 1.7 1 1 0 1 1 1 0 GTP1/OBG ICL PF00463.21 KOO28770.1 - 7.8e-209 694.5 0.7 9.7e-209 694.2 0.7 1.1 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 KOO28770.1 - 3.2e-12 46.4 0.0 8.2e-12 45.1 0.0 1.7 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DHC_N1 PF08385.12 KOO28771.1 - 1.1e-172 575.6 0.9 1.1e-172 575.6 0.9 2.3 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 KOO28771.1 - 1.3e-132 441.7 0.1 2.4e-131 437.6 0.0 3.1 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO28771.1 - 9.7e-105 350.9 3.0 9.7e-105 350.9 3.0 3.6 4 1 1 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO28771.1 - 4.7e-101 337.5 0.4 2.8e-100 335.0 0.0 2.5 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KOO28771.1 - 3.5e-86 289.2 0.0 2.5e-85 286.4 0.0 2.2 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain MT PF12777.7 KOO28771.1 - 3.6e-77 259.7 12.4 8e-77 258.6 12.4 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.7 KOO28771.1 - 2.1e-70 236.3 0.0 8e-70 234.4 0.0 2.1 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_7 PF12775.7 KOO28771.1 - 1.9e-64 216.5 3.1 1.2e-61 207.4 0.1 4.0 4 0 0 4 4 4 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KOO28771.1 - 2.4e-44 151.0 0.0 5.3e-44 149.9 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO28771.1 - 4.5e-35 120.3 0.0 2.2e-34 118.1 0.0 2.4 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 KOO28771.1 - 6.1e-27 93.8 0.4 2.4e-26 91.8 0.4 2.2 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 KOO28771.1 - 1.5e-18 67.1 0.2 5.3e-18 65.3 0.2 2.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO28771.1 - 1.8e-14 53.9 0.0 3.7e-05 23.7 0.0 5.1 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 KOO28771.1 - 0.056 13.8 4.5 1.6 9.0 0.0 3.7 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 KOO28771.1 - 0.07 13.7 0.7 50 4.4 0.0 4.8 5 0 0 5 5 4 0 AAA domain AAA PF00004.29 KOO28771.1 - 0.27 11.7 2.9 16 5.9 0.0 3.9 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) Snapin_Pallidin PF14712.6 KOO28771.1 - 5.6 7.5 7.6 2.6 8.5 1.1 3.8 3 0 0 3 3 3 0 Snapin/Pallidin UAA PF08449.11 KOO28772.1 - 7.3e-47 160.0 9.6 1.3e-46 159.2 9.6 1.3 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO28772.1 - 0.0078 16.4 18.6 0.024 14.8 4.0 2.3 2 0 0 2 2 2 2 EamA-like transporter family RRM_1 PF00076.22 KOO28773.1 - 2e-20 72.4 0.0 3.1e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO28773.1 - 7.5e-06 25.7 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 KOO28773.1 - 5e-05 22.9 0.0 5.3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOO28773.1 - 0.0011 19.0 0.0 0.0016 18.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.11 KOO28773.1 - 0.058 13.4 0.0 0.082 13.0 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Nup35_RRM_2 PF14605.6 KOO28773.1 - 0.063 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Spore_YpjB PF09577.10 KOO28773.1 - 0.077 12.8 0.0 0.28 11.0 0.0 1.7 2 0 0 2 2 2 0 Sporulation protein YpjB (SpoYpjB) MutS_III PF05192.18 KOO28775.1 - 2.2e-27 96.5 0.8 4.9e-27 95.4 0.8 1.6 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 KOO28775.1 - 2.1e-17 63.7 0.1 6e-17 62.2 0.0 1.8 2 0 0 2 2 2 1 MutS domain II MutS_I PF01624.20 KOO28775.1 - 2.6e-07 30.9 0.0 4.8e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 KOO28775.1 - 5.5e-05 23.4 0.0 0.0001 22.6 0.0 1.5 1 0 0 1 1 1 1 MutS family domain IV LRR_6 PF13516.6 KOO28776.1 - 4.1e-21 73.2 32.5 0.0034 17.3 0.1 12.4 14 0 0 14 14 14 8 Leucine Rich repeat LRR_4 PF12799.7 KOO28776.1 - 7.2e-10 39.0 2.7 1.4 9.4 0.0 7.2 6 2 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO28776.1 - 1.4e-05 24.7 14.6 0.13 12.0 0.1 7.5 5 5 1 6 6 6 2 Leucine rich repeat LRR_1 PF00560.33 KOO28776.1 - 0.025 15.1 6.1 3.9e+02 2.3 0.0 7.6 10 0 0 10 10 10 0 Leucine Rich Repeat SE PF08491.10 KOO28777.1 - 0.13 11.3 0.0 0.62 9.1 0.0 1.9 2 0 0 2 2 2 0 Squalene epoxidase Hid1 PF12722.7 KOO28777.1 - 1.7 6.7 4.7 2.2 6.3 4.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MutS_V PF00488.21 KOO28779.1 - 1.6e-73 246.8 0.1 2e-73 246.4 0.1 1.1 1 0 0 1 1 1 1 MutS domain V Pribosyltran PF00156.27 KOO28780.1 - 8.9e-11 41.6 0.1 2.1e-10 40.3 0.1 1.6 1 1 1 2 2 2 1 Phosphoribosyl transferase domain Bax1-I PF01027.20 KOO28781.1 - 6.8e-48 163.2 33.2 8.1e-48 163.0 33.2 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Pro_isomerase PF00160.21 KOO28782.1 - 1.4e-28 100.2 0.0 1.5e-28 100.0 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Myotub-related PF06602.14 KOO28784.1 - 2.3e-80 270.2 0.0 3.7e-80 269.5 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 KOO28784.1 - 0.068 13.1 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Herpes_IE68 PF02479.16 KOO28786.1 - 0.0082 15.7 0.0 0.0089 15.6 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus immediate early protein TPR_2 PF07719.17 KOO28787.1 - 4.2e-10 38.9 3.1 0.0012 18.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO28787.1 - 2e-09 36.9 1.8 0.096 12.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28787.1 - 0.00023 21.7 14.0 0.03 15.1 0.2 4.1 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28787.1 - 0.00055 20.4 1.9 0.012 16.1 1.0 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO28787.1 - 0.0007 19.8 3.5 0.0007 19.8 3.5 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO28787.1 - 0.0032 17.1 0.0 2.8 7.7 0.0 2.6 2 0 0 2 2 2 2 TPR repeat TPR_8 PF13181.6 KOO28787.1 - 0.016 15.4 0.1 6 7.3 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO28787.1 - 0.026 14.6 8.7 0.094 12.9 1.4 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat FlaC_arch PF05377.11 KOO28787.1 - 0.082 13.3 1.5 0.15 12.5 1.5 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Fis1_TPR_C PF14853.6 KOO28787.1 - 0.096 12.8 2.7 0.1 12.7 0.0 2.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat HemY_N PF07219.13 KOO28787.1 - 1.7 8.8 11.5 1.8 8.8 2.7 3.1 2 1 1 3 3 3 0 HemY protein N-terminus TPR_16 PF13432.6 KOO28787.1 - 3.3 8.5 18.0 0.95 10.2 6.1 3.9 2 2 0 2 2 2 0 Tetratricopeptide repeat Imm50 PF15594.6 KOO28788.1 - 0.051 13.8 0.1 0.15 12.3 0.1 1.9 1 1 0 1 1 1 0 Immunity protein 50 SMI1_KNR4 PF09346.10 KOO28788.1 - 0.19 12.1 0.0 0.3 11.5 0.0 1.6 1 1 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) CK1gamma_C PF12605.8 KOO28790.1 - 0.23 12.6 3.8 0.46 11.7 3.8 1.6 1 1 0 1 1 1 0 Casein kinase 1 gamma C terminal Chloroa_b-bind PF00504.21 KOO28791.1 - 5.9e-28 98.4 0.0 1.1e-27 97.6 0.0 1.5 1 0 0 1 1 1 1 Chlorophyll A-B binding protein XAP5 PF04921.14 KOO28792.1 - 1.4e-52 179.0 0.1 2.3e-52 178.3 0.1 1.3 1 0 0 1 1 1 1 XAP5, circadian clock regulator Methyltransf_16 PF10294.9 KOO28792.1 - 1e-12 48.1 0.0 3.5e-12 46.4 0.0 1.7 1 1 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 KOO28792.1 - 1.9e-08 34.1 0.0 4.3e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KOO28792.1 - 1.2e-06 29.2 0.2 5.5e-06 27.0 0.2 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO28792.1 - 1.4e-05 24.7 0.1 2.9e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 KOO28792.1 - 3.1e-05 23.8 0.0 6.9e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO28792.1 - 3.7e-05 23.6 0.0 0.0002 21.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO28792.1 - 0.00012 22.7 0.1 0.00049 20.7 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KOO28792.1 - 0.0018 17.9 0.0 0.0036 17.0 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.12 KOO28792.1 - 0.0058 17.4 0.2 0.022 15.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Helicase_C PF00271.31 KOO28793.1 - 1.4e-12 47.9 0.0 3.1e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Metallophos_2 PF12850.7 KOO28795.1 - 1.4e-05 25.3 0.0 6.2e-05 23.2 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 KOO28795.1 - 3e-05 24.6 0.0 6.2e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_3 PF14582.6 KOO28795.1 - 0.01 15.2 0.0 0.014 14.7 0.0 1.4 1 1 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily TrkA_C PF02080.21 KOO28795.1 - 0.051 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 TrkA-C domain EF-hand_1 PF00036.32 KOO28796.1 - 4.3e-09 35.3 0.7 0.0019 17.6 0.2 2.9 1 1 1 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO28796.1 - 4.3e-09 35.5 1.2 0.0015 17.9 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO28796.1 - 5.6e-09 35.2 0.7 0.0053 16.6 0.1 3.0 1 1 1 2 2 2 2 EF-hand domain ADPrib_exo_Tox PF03496.14 KOO28796.1 - 5.8e-05 22.5 0.0 0.00041 19.7 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme EF-hand_7 PF13499.6 KOO28796.1 - 8.9e-05 22.9 0.1 1 9.9 0.0 3.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO28796.1 - 0.00094 19.0 1.0 0.53 10.2 0.2 3.0 1 1 1 2 2 2 2 EF-hand domain pair ART PF01129.18 KOO28796.1 - 0.0021 17.4 0.0 0.0066 15.8 0.0 1.8 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase PsbN PF02468.15 KOO28799.1 - 0.14 12.0 0.0 0.66 9.9 0.0 2.2 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) LPD30 PF18850.1 KOO28801.1 - 0.0043 16.8 0.1 0.0075 16.0 0.1 1.3 1 0 0 1 1 1 1 Large polyvalent protein associated domain 30 AI-2E_transport PF01594.16 KOO28803.1 - 1.9e-35 122.6 25.8 3.6e-34 118.4 25.8 2.0 1 1 0 1 1 1 1 AI-2E family transporter S1 PF00575.23 KOO28805.1 - 2.2e-37 127.2 1.0 6.7e-19 68.0 0.2 3.2 3 0 0 3 3 3 3 S1 RNA binding domain DUF2110 PF09883.9 KOO28805.1 - 0.1 12.2 0.0 0.35 10.4 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2110) PARP PF00644.20 KOO28806.1 - 7.9e-05 22.3 0.6 0.011 15.3 0.0 2.1 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain ART-PolyVal PF18760.1 KOO28806.1 - 0.14 13.2 0.0 1.4 10.0 0.0 2.0 1 1 0 1 1 1 0 ADP-Ribosyltransferase in polyvalent proteins DAP3 PF10236.9 KOO28807.1 - 1e-20 74.1 0.0 3e-09 36.5 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 KOO28807.1 - 0.0036 17.7 0.2 0.0063 16.9 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 KOO28807.1 - 0.012 15.2 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO28807.1 - 0.027 14.2 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO28807.1 - 0.028 14.3 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 KOO28807.1 - 0.094 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 KOO28807.1 - 0.14 12.4 0.4 0.29 11.4 0.4 1.4 1 0 0 1 1 1 0 AAA domain Glyco_transf_29 PF00777.18 KOO28808.1 - 7.1e-17 61.7 0.1 2.6e-14 53.3 0.1 2.5 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Ank_2 PF12796.7 KOO28809.1 - 1.1e-12 48.4 0.3 1.5e-11 44.7 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO28809.1 - 6.8e-10 39.0 0.3 4.3e-05 23.7 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO28809.1 - 7.9e-07 29.5 0.3 0.006 17.1 0.1 2.8 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO28809.1 - 3.9e-06 26.8 0.2 0.23 12.1 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KOO28809.1 - 7.4e-06 26.2 1.2 0.023 15.1 0.1 2.8 2 1 1 3 3 3 2 Ankyrin repeat MAGE_N PF12440.8 KOO28809.1 - 0.86 10.3 9.8 1.5 9.6 9.8 1.3 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal GILT PF03227.16 KOO28811.1 - 1.2e-08 35.1 3.0 3.6e-08 33.6 2.6 2.2 1 1 1 2 2 2 1 Gamma interferon inducible lysosomal thiol reductase (GILT) EFP PF01132.20 KOO28812.1 - 2.1e-18 66.1 0.0 4.3e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain Elong-fact-P_C PF09285.11 KOO28812.1 - 9.8e-14 50.8 1.4 1.3e-13 50.4 0.6 1.7 2 0 0 2 2 2 1 Elongation factor P, C-terminal EFP_N PF08207.12 KOO28812.1 - 7.7e-05 22.6 0.7 0.00029 20.8 0.0 2.1 2 1 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain UBA PF00627.31 KOO28813.1 - 1.1e-09 37.9 0.0 0.00024 20.9 0.2 3.0 3 0 0 3 3 3 2 UBA/TS-N domain UQ_con PF00179.26 KOO28813.1 - 1.3e-08 34.6 0.0 3.1e-08 33.4 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO28813.1 - 0.018 14.7 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B Prok-E2_A PF14457.6 KOO28813.1 - 0.076 12.6 0.1 0.54 9.9 0.0 2.0 2 0 0 2 2 2 0 Prokaryotic E2 family A DUF3606 PF12244.8 KOO28813.1 - 0.11 12.4 0.0 17 5.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) HOIP-UBA PF16678.5 KOO28813.1 - 0.13 12.2 0.2 3.1 7.8 0.2 2.4 1 1 0 1 1 1 0 HOIP UBA domain pair RWD PF05773.22 KOO28813.1 - 0.15 12.3 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 RWD domain LRR_8 PF13855.6 KOO28817.1 - 1.4e-19 69.6 9.8 6.6e-07 29.0 0.8 4.2 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 KOO28817.1 - 5.6e-12 45.7 13.0 6.8e-05 23.2 0.7 6.0 4 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO28817.1 - 1.3e-07 31.2 5.6 1.5 9.6 0.0 7.4 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 KOO28817.1 - 0.22 11.7 6.6 24 5.3 0.2 5.0 7 0 0 7 7 7 0 Leucine Rich repeat SMI1_KNR4 PF09346.10 KOO28818.1 - 0.025 14.9 0.0 0.04 14.3 0.0 1.3 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) IncD PF17628.2 KOO28818.1 - 0.07 12.9 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Inclusion membrane protein D Orf78 PF06024.12 KOO28819.1 - 0.29 11.4 0.6 4 7.8 0.0 2.2 2 0 0 2 2 2 0 Orf78 (ac78) CbtA PF09490.10 KOO28819.1 - 1.2 8.9 0.0 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) KH_1 PF00013.29 KOO28820.1 - 0.00047 19.9 0.3 0.00092 19.0 0.3 1.5 1 0 0 1 1 1 1 KH domain KH_8 PF17903.1 KOO28820.1 - 0.017 15.2 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Krr1 KH1 domain KCNQC3-Ank-G_bd PF11956.8 KOO28820.1 - 0.082 13.2 0.1 0.2 11.9 0.1 1.7 1 0 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 RRM_1 PF00076.22 KOO28821.1 - 6.7e-14 51.5 0.0 9.3e-14 51.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NT-C2 PF10358.9 KOO28822.1 - 3.4e-07 30.1 0.0 4.9e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins PH PF00169.29 KOO28822.1 - 0.0034 17.9 0.0 0.0053 17.2 0.0 1.3 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.32 KOO28823.1 - 4.4e-42 138.5 11.7 9.3e-10 37.4 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO28823.1 - 2.4e-35 120.8 4.5 5e-18 65.3 1.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO28823.1 - 1.2e-32 111.5 10.3 7.7e-16 57.7 0.6 4.2 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO28823.1 - 8.5e-29 97.0 9.1 2.5e-09 36.3 0.1 4.9 5 0 0 5 5 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO28823.1 - 4.2e-26 89.2 8.4 1.7e-06 27.3 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KOO28823.1 - 1.1e-16 60.9 0.1 3.5e-09 36.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO28823.1 - 2.7e-10 40.1 0.4 0.00026 20.9 0.1 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO28823.1 - 1.4e-09 38.2 0.1 0.00086 19.6 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 KOO28823.1 - 4.1e-05 23.5 0.1 0.083 12.9 0.0 3.1 3 1 0 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 KOO28823.1 - 6.4e-05 23.8 0.0 0.0028 18.5 0.0 2.3 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.10 KOO28823.1 - 0.00019 21.5 0.3 0.00086 19.4 0.1 2.2 2 1 0 2 2 2 1 Ca2+ insensitive EF hand TerB PF05099.13 KOO28823.1 - 0.0016 18.4 0.7 0.57 10.1 0.2 2.7 1 1 1 2 2 2 1 Tellurite resistance protein TerB Dockerin_1 PF00404.18 KOO28823.1 - 0.0019 18.3 4.3 0.073 13.3 0.2 2.9 1 1 2 3 3 3 1 Dockerin type I domain Poly_export PF02563.16 KOO28823.1 - 0.0024 18.0 0.0 0.19 12.0 0.0 3.1 2 2 1 3 3 3 1 Polysaccharide biosynthesis/export protein Caleosin PF05042.13 KOO28823.1 - 0.011 15.7 0.1 0.87 9.5 0.0 2.9 1 1 2 3 3 3 0 Caleosin related protein RNA_pol_Rpb4 PF03874.16 KOO28823.1 - 0.012 15.9 2.2 1.6 9.1 0.2 2.7 2 1 0 2 2 2 0 RNA polymerase Rpb4 DUF1103 PF06513.11 KOO28823.1 - 0.016 14.9 2.8 0.02 14.5 2.3 1.4 1 1 0 1 1 1 0 Repeat of unknown function (DUF1103) DUF3349 PF11829.8 KOO28823.1 - 0.016 15.9 0.3 4.1 8.2 0.0 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) DUF5580 PF17743.1 KOO28823.1 - 0.037 12.6 0.0 0.043 12.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) MotA_activ PF09114.10 KOO28823.1 - 0.097 12.8 0.1 1.2 9.3 0.0 2.2 2 0 0 2 2 2 0 Transcription factor MotA, activation domain SurA_N_2 PF13623.6 KOO28823.1 - 0.12 12.2 0.7 4.7 7.1 0.1 2.4 1 1 1 2 2 2 0 SurA N-terminal domain Spore_III_AB PF09548.10 KOO28823.1 - 0.13 12.3 0.3 0.27 11.3 0.3 1.5 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Kinase-PPPase PF03618.14 KOO28824.1 - 0.044 13.6 0.0 0.057 13.2 0.0 1.1 1 0 0 1 1 1 0 Kinase/pyrophosphorylase ASCH PF04266.14 KOO28824.1 - 0.1 13.2 0.0 0.17 12.5 0.0 1.3 1 0 0 1 1 1 0 ASCH domain Orai-1 PF07856.12 KOO28825.1 - 0.0074 16.0 0.5 0.01 15.5 0.0 1.5 2 0 0 2 2 2 1 Mediator of CRAC channel activity AstE_AspA PF04952.14 KOO28826.1 - 7.6e-06 25.2 0.0 1.1e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.8 KOO28826.1 - 1.2e-05 25.0 0.0 2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) Peptidase_M14 PF00246.24 KOO28826.1 - 4.4e-05 23.4 0.0 7.8e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase Tubulin PF00091.25 KOO28827.1 - 3.9e-59 200.2 0.0 5.5e-59 199.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOO28827.1 - 1.7e-25 89.6 0.0 4e-25 88.4 0.0 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KOO28827.1 - 0.04 14.2 0.0 0.079 13.3 0.0 1.4 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain DUF1411 PF07199.11 KOO28828.1 - 0.058 13.1 0.2 0.15 11.7 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) Cdh1_DBD_1 PF18196.1 KOO28829.1 - 0.0043 17.4 0.9 0.92 9.8 0.0 2.3 1 1 1 2 2 2 2 Chromodomain helicase DNA-binding domain 1 La PF05383.17 KOO28831.1 - 3.3e-20 71.9 0.0 3.9e-11 42.8 0.0 2.4 2 0 0 2 2 2 2 La domain Exo_endo_phos PF03372.23 KOO28831.1 - 5.7e-18 65.3 0.0 1.4e-17 64.0 0.0 1.7 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PTS_2-RNA PF01885.16 KOO28831.1 - 0.21 11.6 0.0 17 5.4 0.0 2.2 2 0 0 2 2 2 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Cupin_8 PF13621.6 KOO28832.1 - 3.2e-24 86.0 0.0 4.1e-24 85.7 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO28832.1 - 6.6e-08 32.4 0.0 2e-07 30.8 0.0 1.7 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 KOO28832.1 - 0.0029 17.3 0.0 0.0053 16.4 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 KOO28832.1 - 0.039 13.6 0.1 0.092 12.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Cupin_6 PF12852.7 KOO28832.1 - 0.04 13.7 0.0 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 Cupin JmjC PF02373.22 KOO28832.1 - 0.08 13.4 0.0 0.14 12.6 0.0 1.6 1 1 0 1 1 1 0 JmjC domain, hydroxylase Peptidase_C48 PF02902.19 KOO28833.1 - 2.9e-23 82.8 0.2 4.9e-23 82.1 0.2 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Ribosomal_S15 PF00312.22 KOO28833.1 - 0.082 13.1 1.7 15 5.9 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S15 HSP70 PF00012.20 KOO28834.1 - 2e-242 805.7 14.3 1.5e-188 627.8 0.2 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 KOO28834.1 - 9.5e-14 50.9 0.6 1.6e-11 43.6 0.0 2.6 1 1 1 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 KOO28834.1 - 0.0026 17.5 0.0 0.009 15.8 0.0 2.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 KOO28834.1 - 6.2 7.3 9.1 5.1 7.6 0.1 3.6 3 2 0 3 3 3 0 Cell division protein FtsA FAM76 PF16046.5 KOO28834.1 - 7.4 5.8 6.6 16 4.7 6.6 1.5 1 0 0 1 1 1 0 FAM76 protein Exonuc_VII_L PF02601.15 KOO28835.1 - 0.027 14.1 6.2 0.026 14.1 6.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1574 PF07611.11 KOO28835.1 - 1.1 8.5 5.0 1.5 8.1 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) DUF1690 PF07956.11 KOO28835.1 - 1.5 9.3 14.5 1.8 9.0 14.5 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) zf-CCHC PF00098.23 KOO28837.1 - 0.054 13.6 0.2 0.093 12.8 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle Phage_GPD PF05954.11 KOO28839.1 - 0.1 11.8 1.5 0.14 11.4 1.5 1.1 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) Apelin PF15360.6 KOO28839.1 - 0.15 12.6 0.9 0.34 11.5 0.9 1.6 1 0 0 1 1 1 0 APJ endogenous ligand Ribosomal_L24e PF01246.20 KOO28840.1 - 5.7e-29 100.1 2.8 5.7e-29 100.1 2.8 1.7 2 0 0 2 2 2 1 Ribosomal protein L24e NAD_Gly3P_dh_N PF01210.23 KOO28840.1 - 0.0023 17.9 0.3 0.0032 17.5 0.3 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus zf-C3HC4_5 PF17121.5 KOO28840.1 - 0.019 14.8 0.5 0.03 14.2 0.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF2175 PF09943.9 KOO28840.1 - 5.6 7.3 8.3 0.58 10.5 0.4 2.7 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) Peptidase_C65 PF10275.9 KOO28842.1 - 4.4e-15 55.8 0.0 6.5e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase C65 Otubain 2OG-FeII_Oxy_3 PF13640.6 KOO28842.1 - 6.5e-06 27.0 0.0 1.4e-05 25.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UIM PF02809.20 KOO28842.1 - 0.011 15.5 0.8 0.033 14.1 0.8 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif DNA_repr_REX1B PF14966.6 KOO28843.1 - 2.4e-11 44.2 0.6 3.4e-11 43.7 0.2 1.4 2 0 0 2 2 2 1 DNA repair REX1-B NUDIX PF00293.28 KOO28844.1 - 0.0071 16.4 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain V_ATPase_I PF01496.19 KOO28845.1 - 0.0029 15.6 0.8 0.0042 15.1 0.8 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family PIG-L PF02585.17 KOO28845.1 - 0.14 12.7 1.7 0.22 12.1 0.9 1.7 1 1 1 2 2 2 0 GlcNAc-PI de-N-acetylase MRP-S26 PF14943.6 KOO28845.1 - 1.3 8.9 9.1 0.44 10.4 6.5 1.5 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 SlyX PF04102.12 KOO28845.1 - 3.1 8.5 10.4 1.2 9.8 1.5 3.3 3 1 1 4 4 4 0 SlyX SAM_2 PF07647.17 KOO28846.1 - 0.0007 19.7 0.0 0.0021 18.1 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KOO28846.1 - 0.0016 18.8 0.1 0.0038 17.6 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Cyclin_N PF00134.23 KOO28846.1 - 0.0025 17.5 0.1 0.0054 16.5 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 KOO28846.1 - 0.011 16.1 0.0 0.14 12.5 0.0 2.1 1 1 1 2 2 2 0 Cyclin Med14 PF08638.11 KOO28849.1 - 0.0087 15.5 1.2 0.11 11.9 0.3 2.5 2 0 0 2 2 2 1 Mediator complex subunit MED14 DraK_HK_N PF18092.1 KOO28849.1 - 0.1 13.1 3.4 0.41 11.1 3.4 2.0 1 0 0 1 1 1 0 DraK Histidine Kinase N-terminal domain DPRP PF04244.13 KOO28849.1 - 0.2 11.5 4.8 0.14 11.9 2.8 1.7 1 1 1 2 2 2 0 Deoxyribodipyrimidine photo-lyase-related protein Baculo_PEP_C PF04513.12 KOO28849.1 - 0.28 11.2 3.4 25 4.9 0.0 3.4 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HMMR_N PF15905.5 KOO28849.1 - 0.39 10.1 17.2 0.038 13.5 8.5 2.5 2 2 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 KOO28849.1 - 3.3 6.5 24.3 0.94 8.3 8.3 2.9 1 1 3 4 4 4 0 Spc7 kinetochore protein DUF641 PF04859.12 KOO28849.1 - 6.8 7.0 13.9 0.38 11.1 1.0 3.7 2 2 2 4 4 4 0 Plant protein of unknown function (DUF641) Phage_Mu_Gam PF07352.12 KOO28849.1 - 7.4 6.5 10.6 0.29 11.0 1.6 3.1 2 1 2 5 5 5 0 Bacteriophage Mu Gam like protein FAM76 PF16046.5 KOO28849.1 - 7.9 5.7 7.7 1.3 8.3 0.3 2.2 1 1 0 2 2 2 0 FAM76 protein F420_oxidored PF03807.17 KOO28851.1 - 9.4e-07 29.3 0.2 2e-06 28.3 0.2 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.9 KOO28851.1 - 7.5e-06 25.8 1.1 1.7e-05 24.7 1.1 1.6 1 0 0 1 1 1 1 Rossmann-like domain ApbA PF02558.16 KOO28851.1 - 0.00072 19.2 0.1 0.0013 18.4 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 KOO28851.1 - 0.00077 19.7 0.0 0.0016 18.7 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 KOO28851.1 - 0.0053 16.1 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Luteo_Vpg PF01659.16 KOO28851.1 - 0.069 13.5 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Luteovirus putative VPg genome linked protein Bacteriocin_IIc PF10439.9 KOO28851.1 - 0.72 10.0 7.0 8.3 6.6 0.3 2.7 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide SIR2 PF02146.17 KOO28852.1 - 5.5e-31 107.9 0.0 9.6e-31 107.1 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 KOO28852.1 - 5.9e-06 26.1 0.0 0.017 14.8 0.0 2.6 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Filo_VP35 PF02097.15 KOO28852.1 - 0.39 9.7 3.8 3 6.8 0.3 2.2 2 0 0 2 2 2 0 Filoviridae VP35 DUF4074 PF13293.6 KOO28855.1 - 0.046 14.0 0.4 0.089 13.1 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4074) rve PF00665.26 KOO28856.1 - 5.7e-07 29.8 0.0 1.7e-06 28.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain GHL13 PF14883.6 KOO28857.1 - 0.12 11.4 0.2 0.17 10.9 0.2 1.1 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 PX PF00787.24 KOO28858.1 - 4.4e-23 81.4 0.0 1.1e-22 80.2 0.0 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 KOO28858.1 - 0.00042 19.9 10.3 0.0032 17.1 8.2 3.2 2 1 0 2 2 2 1 Vps5 C terminal like Med9 PF07544.13 KOO28858.1 - 0.032 14.3 5.2 0.45 10.6 0.0 3.2 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4795 PF16043.5 KOO28858.1 - 0.085 12.5 1.8 12 5.4 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) TBCC_N PF16752.5 KOO28858.1 - 0.093 13.2 1.5 2.8 8.4 0.7 2.5 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Laminin_II PF06009.12 KOO28858.1 - 0.15 12.1 2.3 2.9 7.9 1.9 2.4 2 0 0 2 2 2 0 Laminin Domain II DUF948 PF06103.11 KOO28858.1 - 0.17 12.1 0.2 14 6.0 0.6 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc24 PF08286.11 KOO28858.1 - 2.5 8.4 5.4 5 7.4 0.3 2.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Csm1_N PF18504.1 KOO28858.1 - 3.7 8.0 5.7 14 6.1 2.0 2.8 2 1 1 3 3 3 0 Csm1 N-terminal domain CBFD_NFYB_HMF PF00808.23 KOO28859.1 - 8.2e-16 58.1 0.7 8.2e-16 58.1 0.7 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOO28859.1 - 0.00012 22.4 0.8 0.00016 22.1 0.2 1.4 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 KOO28859.1 - 0.0089 16.0 0.1 0.019 15.0 0.1 1.7 1 1 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit bZIP_1 PF00170.21 KOO28861.1 - 0.086 13.0 2.1 0.17 12.0 2.1 1.4 1 0 0 1 1 1 0 bZIP transcription factor Spc29 PF17082.5 KOO28861.1 - 0.1 12.4 0.5 0.13 12.1 0.5 1.1 1 0 0 1 1 1 0 Spindle Pole Component 29 Adenine_glyco PF03352.13 KOO28862.1 - 9.1e-56 188.4 0.0 1.3e-55 187.9 0.0 1.2 1 0 0 1 1 1 1 Methyladenine glycosylase K_channel_TID PF07941.11 KOO28862.1 - 4.7 7.7 11.9 7.4 7.1 0.4 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain zf-RING_2 PF13639.6 KOO28863.1 - 1.7e-09 37.8 4.2 2.9e-09 37.1 4.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO28863.1 - 1.1e-07 31.6 3.2 1.7e-07 30.9 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO28863.1 - 1.1e-06 28.4 2.4 1.6e-06 27.9 2.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOO28863.1 - 1.5e-06 28.4 7.9 3.7e-06 27.1 7.9 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KOO28863.1 - 3.5e-06 26.7 2.9 7.1e-06 25.7 2.9 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 KOO28863.1 - 2.6e-05 24.1 2.9 3.9e-05 23.5 2.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOO28863.1 - 0.00014 21.7 2.1 0.00022 21.0 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO28863.1 - 0.0002 21.3 0.9 0.00036 20.5 0.9 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-HC5HC2H PF13771.6 KOO28863.1 - 0.036 14.3 0.5 0.062 13.6 0.5 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-ANAPC11 PF12861.7 KOO28863.1 - 0.039 14.0 4.9 0.13 12.3 4.8 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KOO28863.1 - 0.044 13.4 5.1 0.08 12.6 5.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 KOO28863.1 - 0.059 13.3 5.3 2.1 8.3 6.7 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 KOO28863.1 - 0.084 13.2 4.9 0.13 12.5 4.9 1.3 1 0 0 1 1 1 0 RING-like domain zf-Nse PF11789.8 KOO28863.1 - 0.1 12.4 1.7 0.26 11.1 1.7 1.8 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-P11 PF03854.14 KOO28863.1 - 0.22 11.2 0.3 0.22 11.2 0.3 1.4 2 0 0 2 2 1 0 P-11 zinc finger zf-RING_4 PF14570.6 KOO28863.1 - 0.47 10.3 4.9 4.9 7.0 0.1 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Ribosomal_S27e PF01667.17 KOO28863.1 - 1.2 8.9 4.0 0.36 10.6 0.4 1.8 2 0 0 2 2 2 0 Ribosomal protein S27 FANCL_C PF11793.8 KOO28863.1 - 5.3 7.3 7.1 32 4.8 7.1 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain FAM27 PF15832.5 KOO28864.1 - 1.3 9.6 10.8 0.2 12.2 5.6 2.3 2 1 1 3 3 3 0 FAM27 D and E protein family adh_short PF00106.25 KOO28865.1 - 2.5e-22 79.3 0.1 4.2e-22 78.6 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO28865.1 - 1e-12 48.1 0.1 1.4e-12 47.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Alb1 PF09135.11 KOO28866.1 - 0.17 12.8 2.1 0.24 12.3 0.5 2.1 2 0 0 2 2 2 0 Alb1 DUF1631 PF07793.11 KOO28866.1 - 1.1 7.6 12.3 0.11 11.0 6.1 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1631) CAP_N PF01213.19 KOO28866.1 - 4.8 6.6 11.9 0.25 10.8 5.9 1.8 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Myb_DNA-binding PF00249.31 KOO28867.1 - 8.3e-08 32.3 0.4 8.3e-08 32.3 0.4 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO28867.1 - 4.3e-06 26.9 0.0 1.1e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain RHH_1 PF01402.21 KOO28867.1 - 0.71 9.9 7.3 0.18 11.8 1.5 2.7 2 1 1 3 3 3 0 Ribbon-helix-helix protein, copG family WD40 PF00400.32 KOO28868.1 - 8.3e-34 115.1 14.4 3.2e-06 27.7 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO28868.1 - 2.5e-07 30.9 0.2 0.31 11.4 0.0 5.1 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KOO28868.1 - 2e-05 24.9 1.1 0.12 12.9 0.0 4.8 5 0 0 5 5 5 1 PQQ-like domain PQQ_2 PF13360.6 KOO28868.1 - 0.00035 20.2 1.2 0.029 13.9 0.1 2.3 1 1 1 2 2 2 2 PQQ-like domain Nup160 PF11715.8 KOO28868.1 - 0.00044 19.0 0.5 0.79 8.3 0.2 3.3 3 2 0 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOO28868.1 - 0.1 11.5 0.2 21 3.9 0.0 3.6 3 2 2 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KOO28868.1 - 0.2 11.0 0.0 1.2 8.4 0.0 2.2 2 1 1 3 3 3 0 WD40-like domain DUF5122 PF17164.4 KOO28868.1 - 0.31 11.4 1.1 8 6.8 0.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller TPR_MLP1_2 PF07926.12 KOO28870.1 - 0.01 15.9 13.9 0.01 15.9 13.9 4.4 1 1 3 4 4 4 1 TPR/MLP1/MLP2-like protein ING PF12998.7 KOO28870.1 - 0.28 11.8 8.5 0.031 14.8 2.7 2.4 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding RasGAP_C PF03836.15 KOO28870.1 - 5.4 7.2 14.2 2.2 8.4 0.3 3.5 1 1 0 3 3 3 0 RasGAP C-terminus AMP-binding PF00501.28 KOO28871.1 - 2.1e-79 267.1 0.1 7.5e-79 265.3 0.1 1.8 1 1 0 1 1 1 1 AMP-binding enzyme Oxidored_nitro PF00148.19 KOO28871.1 - 0.064 12.0 0.2 0.25 10.0 0.1 1.9 1 1 1 2 2 2 0 Nitrogenase component 1 type Oxidoreductase PPR_2 PF13041.6 KOO28872.1 - 1.1e-105 345.7 0.0 4.4e-12 46.0 0.0 12.2 3 3 10 13 13 13 13 PPR repeat family PPR_1 PF12854.7 KOO28872.1 - 3.7e-82 269.7 0.0 1.2e-09 37.7 0.1 14.2 14 0 0 14 14 14 11 PPR repeat PPR PF01535.20 KOO28872.1 - 2.6e-74 240.4 0.0 1.7e-08 34.1 0.0 13.4 13 0 0 13 13 13 12 PPR repeat PPR_3 PF13812.6 KOO28872.1 - 2.9e-63 209.8 0.0 8.6e-11 41.8 0.0 8.3 7 1 1 8 8 8 8 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO28872.1 - 1.6e-36 125.7 4.7 1.6e-08 34.2 0.7 5.2 1 1 4 5 5 5 5 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 KOO28872.1 - 3.8e-10 39.7 43.7 0.69 10.9 0.2 10.8 4 2 7 11 11 10 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO28872.1 - 2.4e-09 37.6 13.6 0.0027 18.2 0.2 5.9 6 2 0 6 6 6 2 Tetratricopeptide repeat BKACE PF05853.12 KOO28872.1 - 2.1e-06 27.2 0.4 0.3 10.3 0.0 4.8 1 1 3 4 4 4 1 beta-keto acid cleavage enzyme DUF3368 PF11848.8 KOO28872.1 - 5.4e-06 26.1 0.1 1.8 8.4 0.0 5.7 7 0 0 7 7 6 2 Domain of unknown function (DUF3368) TPR_4 PF07721.14 KOO28872.1 - 0.00015 22.1 60.9 1.5 9.7 0.4 11.0 11 0 0 11 11 11 6 Tetratricopeptide repeat ECSIT PF06239.11 KOO28872.1 - 0.00024 20.3 0.0 0.42 9.7 0.0 4.3 5 0 0 5 5 5 1 Evolutionarily conserved signalling intermediate in Toll pathway SPOB_a PF14689.6 KOO28872.1 - 0.0045 16.7 0.0 7.9 6.3 0.0 4.1 5 0 0 5 5 5 1 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_16 PF13432.6 KOO28872.1 - 0.006 17.2 37.3 0.062 14.0 1.2 6.9 6 1 1 7 7 6 2 Tetratricopeptide repeat MRP-S27 PF10037.9 KOO28872.1 - 0.012 14.5 0.0 0.28 10.0 0.0 2.7 2 1 0 3 3 3 0 Mitochondrial 28S ribosomal protein S27 ANAPC3 PF12895.7 KOO28872.1 - 0.016 15.4 1.8 34 4.8 0.0 4.3 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Wzy_C_2 PF11846.8 KOO28872.1 - 0.037 14.0 23.8 4.7 7.1 0.0 8.6 6 3 5 11 11 11 0 Virulence factor membrane-bound polymerase, C-terminal SelB-wing_2 PF09106.11 KOO28872.1 - 0.042 14.0 3.2 1.3 9.3 0.0 4.4 5 0 0 5 5 4 0 Elongation factor SelB, winged helix B12-binding_2 PF02607.17 KOO28872.1 - 0.054 13.9 1.3 29 5.2 0.0 4.5 5 0 0 5 5 4 0 B12 binding domain Inhibitor_I9 PF05922.16 KOO28872.1 - 0.15 12.7 0.2 28 5.5 0.0 4.3 4 1 1 5 5 5 0 Peptidase inhibitor I9 Clathrin PF00637.20 KOO28872.1 - 0.18 11.7 0.0 44 3.9 0.0 3.6 2 2 1 4 4 4 0 Region in Clathrin and VPS TPR_2 PF07719.17 KOO28872.1 - 0.46 10.7 12.8 43 4.6 0.1 7.2 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO28872.1 - 9.3 6.5 10.4 1.6e+02 2.7 0.0 6.4 8 1 0 8 8 8 0 Tetratricopeptide repeat Ni_hydr_CYTB PF01292.20 KOO28873.1 - 2.6e-17 63.0 9.4 3.2e-17 62.7 9.4 1.1 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 Ferric_reduct PF01794.19 KOO28873.1 - 0.13 12.4 6.2 0.53 10.4 0.5 2.4 2 1 0 2 2 2 0 Ferric reductase like transmembrane component Ubiq_cyt_C_chap PF03981.12 KOO28875.1 - 1e-12 48.3 0.0 1.7e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone AAA PF00004.29 KOO28878.1 - 7.2e-34 117.1 0.1 3e-15 56.8 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_6 PF17866.1 KOO28878.1 - 8e-25 86.8 8.4 3e-13 49.7 0.9 3.9 4 0 0 4 4 3 2 AAA lid domain AAA_22 PF13401.6 KOO28878.1 - 4.1e-11 43.3 2.2 0.28 11.5 0.0 5.1 3 2 0 5 5 4 3 AAA domain AAA_5 PF07728.14 KOO28878.1 - 1.5e-10 41.2 0.3 0.00041 20.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOO28878.1 - 2.6e-10 40.3 1.5 0.00044 20.0 0.2 3.0 2 2 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO28878.1 - 6.2e-08 33.2 2.2 0.022 15.1 0.0 3.4 2 1 0 2 2 2 2 AAA ATPase domain Mg_chelatase PF01078.21 KOO28878.1 - 3.2e-07 30.0 4.6 0.014 14.8 0.1 3.8 2 2 2 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 KOO28878.1 - 3.9e-07 30.0 1.4 0.00091 19.0 0.3 2.8 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KOO28878.1 - 9.3e-07 29.5 0.1 0.021 15.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 KOO28878.1 - 1.8e-06 27.8 1.0 0.38 10.4 0.1 4.0 2 2 0 2 2 2 2 Sigma-54 interaction domain CAP_GLY PF01302.25 KOO28878.1 - 6.8e-06 26.0 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain AAA_19 PF13245.6 KOO28878.1 - 2.2e-05 24.8 1.5 0.25 11.7 0.3 2.8 2 1 0 2 2 2 2 AAA domain DUF815 PF05673.13 KOO28878.1 - 2.9e-05 23.4 2.2 0.22 10.6 0.0 3.9 4 1 1 5 5 5 2 Protein of unknown function (DUF815) Torsin PF06309.11 KOO28878.1 - 8e-05 22.8 0.1 0.3 11.2 0.0 2.7 2 1 0 2 2 2 2 Torsin AAA_33 PF13671.6 KOO28878.1 - 8.2e-05 22.8 0.4 0.14 12.3 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 KOO28878.1 - 0.0002 21.5 0.1 0.77 9.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) NTPase_1 PF03266.15 KOO28878.1 - 0.00023 21.1 0.1 0.53 10.2 0.0 2.6 2 0 0 2 2 2 2 NTPase Viral_helicase1 PF01443.18 KOO28878.1 - 0.00026 20.8 0.0 0.17 11.6 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 KOO28878.1 - 0.00026 20.8 0.2 0.61 9.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KOO28878.1 - 0.00028 21.2 0.1 0.3 11.5 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_28 PF13521.6 KOO28878.1 - 0.00037 20.8 1.0 0.11 12.8 0.1 3.3 2 2 1 3 3 3 1 AAA domain Zeta_toxin PF06414.12 KOO28878.1 - 0.00082 18.7 0.1 0.87 8.8 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_7 PF12775.7 KOO28878.1 - 0.00093 18.8 0.1 1.3 8.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region TrwB_AAD_bind PF10412.9 KOO28878.1 - 0.0011 18.0 0.2 0.99 8.2 0.0 2.4 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain Sigma54_activ_2 PF14532.6 KOO28878.1 - 0.0011 19.1 0.0 1.2 9.3 0.0 3.1 2 2 0 2 2 2 1 Sigma-54 interaction domain MCM PF00493.23 KOO28878.1 - 0.0011 18.1 0.2 0.32 10.0 0.0 2.6 3 0 0 3 3 2 1 MCM P-loop domain KTI12 PF08433.10 KOO28878.1 - 0.0016 18.0 0.1 0.38 10.2 0.0 2.3 2 0 0 2 2 2 1 Chromatin associated protein KTI12 TsaE PF02367.17 KOO28878.1 - 0.0018 18.2 0.1 0.39 10.7 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 KOO28878.1 - 0.0022 18.4 1.5 1.4 9.3 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KOO28878.1 - 0.0024 17.7 0.0 1.8 8.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 KOO28878.1 - 0.0053 16.7 0.3 2.8 7.8 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase Parvo_NS1 PF01057.17 KOO28878.1 - 0.0066 15.6 0.0 1.4 8.0 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 DUF3987 PF13148.6 KOO28878.1 - 0.011 14.8 0.3 7.2 5.5 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) ResIII PF04851.15 KOO28878.1 - 0.018 15.1 0.1 8.7 6.3 0.0 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit SKI PF01202.22 KOO28878.1 - 0.018 15.1 0.4 2.4 8.3 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase CbiA PF01656.23 KOO28878.1 - 0.019 15.0 0.4 0.25 11.4 0.1 2.7 2 2 1 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2075 PF09848.9 KOO28878.1 - 0.02 14.2 2.2 5.6 6.1 0.3 3.5 2 2 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 KOO28878.1 - 0.028 14.9 0.1 9.5 6.7 0.0 2.4 2 0 0 2 2 2 0 ABC transporter IstB_IS21 PF01695.17 KOO28878.1 - 0.044 13.5 0.2 7.8 6.2 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 KOO28878.1 - 0.048 13.6 1.6 1.8 8.5 0.0 2.9 3 0 0 3 3 3 0 NACHT domain TniB PF05621.11 KOO28878.1 - 0.057 12.8 0.0 22 4.4 0.0 3.7 3 1 1 4 4 4 0 Bacterial TniB protein TetR PF13972.6 KOO28878.1 - 0.073 12.8 0.0 0.24 11.1 0.0 1.9 1 0 0 1 1 1 0 Bacterial transcriptional repressor ADK PF00406.22 KOO28878.1 - 0.077 13.1 0.4 1.2 9.3 0.1 2.6 2 0 0 2 2 2 0 Adenylate kinase ParA PF10609.9 KOO28878.1 - 0.082 12.3 0.3 0.82 9.1 0.0 2.1 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase AAA_24 PF13479.6 KOO28878.1 - 0.084 12.6 0.1 11 5.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 KOO28878.1 - 0.088 12.5 0.3 3.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase Zot PF05707.12 KOO28878.1 - 0.13 11.8 0.3 35 4.0 0.0 3.7 2 2 0 2 2 2 0 Zonular occludens toxin (Zot) AAA_10 PF12846.7 KOO28878.1 - 0.18 10.7 0.8 18 4.1 0.0 3.1 4 0 0 4 4 4 0 AAA-like domain NB-ARC PF00931.22 KOO28878.1 - 0.24 10.6 0.2 5.2 6.2 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Metallophos_2 PF12850.7 KOO28879.1 - 1.2e-21 77.6 0.0 1.5e-21 77.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 KOO28879.1 - 5.1e-06 27.1 0.7 0.0013 19.3 0.7 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase CorA PF01544.18 KOO28880.1 - 0.00074 18.9 1.4 0.0035 16.7 0.1 2.3 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF2721 PF11026.8 KOO28880.1 - 0.0079 16.1 0.1 0.022 14.6 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2721) Tmemb_cc2 PF10267.9 KOO28880.1 - 0.041 13.0 0.2 0.065 12.4 0.2 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein ABC_membrane PF00664.23 KOO28881.1 - 1.6e-46 159.2 1.4 2.2e-46 158.7 1.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOO28881.1 - 2.4e-31 109.1 0.0 3.9e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOO28881.1 - 1.6e-05 24.5 0.0 8.7e-05 22.0 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 KOO28881.1 - 0.092 13.0 1.8 1.2 9.4 0.6 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 KOO28881.1 - 0.13 12.6 0.1 1.6 9.0 0.1 2.4 1 1 0 1 1 1 0 AAA domain CLP_protease PF00574.23 KOO28883.1 - 4.2e-53 180.0 0.0 6e-53 179.4 0.0 1.2 1 0 0 1 1 1 1 Clp protease PTPS_related PF10131.9 KOO28884.1 - 0.13 10.5 0.6 0.17 10.2 0.6 1.0 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein SET PF00856.28 KOO28885.1 - 9.3e-10 39.1 0.0 2.3e-09 37.9 0.0 1.7 1 1 0 1 1 1 1 SET domain WD40 PF00400.32 KOO28886.1 - 3.8e-62 204.8 20.5 2.2e-08 34.6 0.1 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO28886.1 - 2.2e-20 72.7 2.9 0.061 13.6 0.1 7.2 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO28886.1 - 7.4e-20 71.2 10.6 0.047 12.7 0.0 7.1 1 1 5 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein Dynamin_N PF00350.23 KOO28886.1 - 2.4e-18 66.7 0.0 4.2e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Dynamin family Arm PF00514.23 KOO28886.1 - 1.6e-10 40.6 7.0 1.5e-05 24.8 0.4 5.1 5 0 0 5 5 4 2 Armadillo/beta-catenin-like repeat PD40 PF07676.12 KOO28886.1 - 4.8e-10 39.1 0.2 3.8 7.5 0.0 6.5 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 KOO28886.1 - 1.4e-09 38.1 0.1 0.00019 21.4 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 KOO28886.1 - 1.8e-08 34.4 0.5 0.011 15.7 0.0 4.5 2 1 2 4 4 4 3 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 KOO28886.1 - 9.5e-08 30.8 0.1 0.52 8.6 0.0 4.9 1 1 2 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 KOO28886.1 - 3e-06 26.8 2.3 0.057 12.7 0.0 3.0 3 0 0 3 3 3 2 WD40-like domain U-box PF04564.15 KOO28886.1 - 0.00031 20.8 0.0 0.00071 19.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain MMR_HSR1 PF01926.23 KOO28886.1 - 0.0018 18.3 0.0 0.014 15.5 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase HEAT PF02985.22 KOO28886.1 - 0.0047 17.1 1.8 0.14 12.5 0.1 4.2 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 KOO28886.1 - 0.0053 17.2 1.3 0.0053 17.2 1.3 4.9 4 1 0 4 4 4 1 HEAT-like repeat PHTB1_N PF14727.6 KOO28886.1 - 0.013 14.9 0.2 2.2 7.6 0.0 3.6 2 2 3 5 5 5 0 PTHB1 N-terminus zf-NOSIP PF15906.5 KOO28886.1 - 0.038 14.1 0.0 0.19 11.9 0.0 2.2 2 0 0 2 2 1 0 Zinc-finger of nitric oxide synthase-interacting protein Dynamin_M PF01031.20 KOO28886.1 - 0.044 13.0 0.0 0.97 8.6 0.0 2.2 1 1 1 2 2 2 0 Dynamin central region Utp8 PF10395.9 KOO28886.1 - 0.084 11.4 0.6 2.8 6.4 0.1 2.6 1 1 1 3 3 3 0 Utp8 family HEAT_2 PF13646.6 KOO28886.1 - 0.13 12.7 19.1 0.029 14.7 4.6 3.9 3 1 0 3 3 2 0 HEAT repeats TFA2_Winged_2 PF18121.1 KOO28886.1 - 0.16 11.7 0.0 0.55 10.0 0.0 2.0 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 Big_7 PF17957.1 KOO28886.1 - 0.45 11.3 12.4 3.6 8.4 0.2 5.5 1 1 2 4 4 4 0 Bacterial Ig domain UCH PF00443.29 KOO28887.1 - 4.6e-24 85.3 0.0 9e-23 81.1 0.0 2.1 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 KOO28887.1 - 1e-10 41.2 0.0 2e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UCH_1 PF13423.6 KOO28887.1 - 8.2e-09 35.5 1.0 0.00021 21.0 0.3 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Rad60-SLD PF11976.8 KOO28887.1 - 0.09 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KOO28887.1 - 0.15 12.5 0.0 0.42 11.1 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain Gly-rich_Ago1 PF12764.7 KOO28887.1 - 0.41 11.4 0.1 0.41 11.4 0.1 2.7 3 0 0 3 3 3 0 Glycine-rich region of argonaut FWWh PF14922.6 KOO28888.1 - 5.7e-08 32.8 0.0 7.7e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF5536 PF17688.1 KOO28888.1 - 0.00033 20.6 0.2 0.00044 20.2 0.2 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5536) EF-hand_6 PF13405.6 KOO28889.1 - 0.0017 18.1 0.2 0.029 14.3 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO28889.1 - 0.36 10.5 0.0 0.36 10.5 0.0 2.6 3 0 0 3 3 3 0 EF hand Ank_3 PF13606.6 KOO28890.1 - 1.2e-12 46.8 1.4 0.0091 16.4 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KOO28890.1 - 4.6e-11 43.0 0.0 1.2e-07 32.1 0.0 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO28890.1 - 5.9e-11 42.8 0.3 7.3e-06 26.5 0.0 3.1 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO28890.1 - 6.5e-06 26.3 2.3 0.0022 18.3 0.1 3.8 2 2 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO28890.1 - 0.0089 16.4 15.5 0.14 12.7 0.0 4.7 5 1 0 5 5 5 2 Ankyrin repeat DUF2497 PF10691.9 KOO28890.1 - 0.11 13.0 0.1 12 6.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2497) EF-hand_6 PF13405.6 KOO28891.1 - 3.4e-14 51.5 2.4 0.0034 17.2 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 KOO28891.1 - 3.9e-13 49.6 12.2 1.1e-05 25.8 0.4 3.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO28891.1 - 2.4e-12 45.5 2.6 0.074 12.6 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO28891.1 - 8.5e-06 25.5 5.3 0.074 12.9 0.1 4.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO28891.1 - 9.5e-05 21.7 5.8 0.047 13.2 0.1 3.9 4 0 0 4 4 4 2 EF hand Caleosin PF05042.13 KOO28891.1 - 0.01 15.8 0.1 0.045 13.7 0.0 2.0 1 1 1 2 2 2 0 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO28891.1 - 0.055 13.8 0.0 0.91 9.9 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region SPOC PF07744.13 KOO28891.1 - 0.093 12.6 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 SPOC domain Cob_adeno_trans PF01923.18 KOO28892.1 - 6.8e-54 182.4 0.0 7.9e-54 182.2 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase Ceramidase PF05875.12 KOO28893.1 - 9.3e-19 67.9 5.8 1.1e-18 67.6 5.8 1.1 1 0 0 1 1 1 1 Ceramidase GTP-bdg_N PF13167.6 KOO28894.1 - 2.7e-28 98.5 0.1 6.1e-28 97.3 0.1 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal GTP-bdg_M PF16360.5 KOO28894.1 - 5.3e-22 78.2 1.4 8.6e-22 77.5 1.4 1.3 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.23 KOO28894.1 - 2.4e-20 72.7 0.1 6.1e-20 71.4 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOO28894.1 - 0.00012 22.2 0.1 0.012 15.7 0.0 2.3 2 0 0 2 2 2 1 Dynamin family cobW PF02492.19 KOO28894.1 - 0.00032 20.3 4.3 0.14 11.7 0.2 2.7 2 1 1 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 KOO28894.1 - 0.00041 19.9 0.1 0.3 10.6 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOO28894.1 - 0.00046 19.8 0.4 0.0017 17.9 0.4 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 KOO28894.1 - 0.00052 20.5 0.0 0.0013 19.2 0.0 1.7 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 KOO28894.1 - 0.00079 19.4 0.0 0.035 14.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KOO28894.1 - 0.0093 16.4 0.6 0.02 15.3 0.6 1.5 1 0 0 1 1 1 1 AAA ATPase domain Arf PF00025.21 KOO28894.1 - 0.013 15.0 0.1 3.6 7.0 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_23 PF13476.6 KOO28894.1 - 0.027 15.0 0.1 0.073 13.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain EF-hand_6 PF13405.6 KOO28895.1 - 2.4e-32 108.0 11.1 5.1e-06 26.0 0.1 8.0 8 0 0 8 8 8 6 EF-hand domain EF-hand_1 PF00036.32 KOO28895.1 - 3.3e-32 107.6 10.0 5.9e-06 25.5 0.4 8.4 8 0 0 8 8 8 6 EF hand EF-hand_7 PF13499.6 KOO28895.1 - 4.7e-27 94.3 3.4 1.2e-08 35.3 0.0 6.2 5 2 2 7 7 7 5 EF-hand domain pair EF-hand_8 PF13833.6 KOO28895.1 - 3.7e-23 81.1 9.3 0.00016 21.4 0.0 7.6 7 1 1 8 8 8 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO28895.1 - 3.8e-12 45.1 15.9 3.5e-05 23.1 0.3 6.9 7 0 0 7 7 7 4 EF hand p25-alpha PF05517.12 KOO28895.1 - 0.025 14.7 0.0 12 6.0 0.0 3.9 4 0 0 4 4 4 0 p25-alpha Asp-B-Hydro_N PF05279.11 KOO28895.1 - 0.063 13.3 0.1 0.063 13.3 0.1 2.1 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region WD40 PF00400.32 KOO28897.1 - 9.1e-54 178.2 13.9 1.3e-09 38.5 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO28897.1 - 8.2e-18 64.4 5.1 0.0058 15.6 0.0 5.0 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO28897.1 - 1.3e-15 57.4 0.5 0.076 13.3 0.1 5.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO28897.1 - 3.4e-14 52.3 2.4 0.58 10.2 0.0 5.4 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat eIF2A PF08662.11 KOO28897.1 - 4.8e-12 46.1 0.6 0.00049 20.0 0.0 2.5 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 KOO28897.1 - 1.3e-07 31.2 2.4 0.37 10.1 0.2 4.1 1 1 3 4 4 4 3 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 KOO28897.1 - 2.2e-06 27.2 0.9 0.00025 20.5 0.7 2.4 1 1 1 2 2 2 1 WD40-like domain Frtz PF11768.8 KOO28897.1 - 2.6e-06 26.1 0.0 0.16 10.2 0.0 3.8 1 1 2 4 4 4 3 WD repeat-containing and planar cell polarity effector protein Fritz Plk4_PB1 PF18190.1 KOO28897.1 - 0.00011 22.4 1.0 15 5.8 0.1 4.6 1 1 4 5 5 5 0 Polo-like Kinase 4 Polo Box 1 P22_Tail-4 PF11650.8 KOO28897.1 - 0.00014 21.9 0.0 20 5.1 0.0 4.7 1 1 4 5 5 5 0 P22 tail accessory factor DCX PF03607.17 KOO28897.1 - 0.00029 20.9 0.0 13 6.0 0.0 4.8 5 0 0 5 5 5 0 Doublecortin WD40_3 PF15911.5 KOO28897.1 - 0.00072 19.5 0.7 60 3.8 0.0 4.9 5 0 0 5 5 5 0 WD domain, G-beta repeat PQQ_3 PF13570.6 KOO28897.1 - 0.0017 18.8 0.8 11 6.6 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain Dfp1_Him1_M PF08630.10 KOO28897.1 - 0.0022 18.2 0.6 14 5.9 0.0 3.8 4 0 0 4 4 4 0 Dfp1/Him1, central region Psu PF07455.11 KOO28897.1 - 0.0044 16.6 0.2 38 3.8 0.0 4.2 4 0 0 4 4 4 0 Phage polarity suppression protein (Psu) Spc110_C PF18520.1 KOO28897.1 - 0.0065 16.1 1.3 40 3.9 0.0 4.6 5 0 0 5 5 5 0 Spindle pole body component 110 C-terminal domain UN_NPL4 PF11543.8 KOO28897.1 - 0.034 14.6 0.9 1.7e+02 2.8 0.0 4.7 5 0 0 5 5 5 0 Nuclear pore localisation protein NPL4 GluRS_N PF18466.1 KOO28897.1 - 0.1 13.0 8.0 2.9 8.4 0.0 4.5 4 1 0 5 5 5 0 Glutamate--tRNA ligase N-terminal domain Proteasome_A_N PF10584.9 KOO28897.1 - 5.9 6.7 14.6 1e+02 2.7 0.1 5.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature XRN_N PF03159.18 KOO28898.1 - 4.1e-78 262.2 0.0 1.5e-39 135.9 0.0 2.1 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 KOO28898.1 - 3.7e-20 72.3 0.0 5.5e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Xrn1 helical domain Ubiq_cyt_C_chap PF03981.12 KOO28899.1 - 0.067 13.3 3.2 0.075 13.1 0.6 2.2 2 0 0 2 2 2 0 Ubiquinol-cytochrome C chaperone DUF3632 PF12311.8 KOO28899.1 - 0.16 12.4 5.1 0.62 10.5 1.0 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3632) DR2241 PF18069.1 KOO28900.1 - 0.022 14.6 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 DR2241 stabilising domain EF-hand_1 PF00036.32 KOO28901.1 - 1.8e-27 92.8 8.3 1.6e-07 30.4 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO28901.1 - 5e-26 90.9 1.1 4.5e-12 46.2 0.6 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO28901.1 - 1.1e-20 71.8 5.6 1.1e-06 28.0 0.3 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO28901.1 - 1.8e-20 72.5 5.2 2.2e-10 40.2 0.2 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO28901.1 - 8.6e-18 63.0 9.8 1.7e-05 24.1 0.6 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KOO28901.1 - 1.1e-06 28.8 0.1 0.00025 21.3 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO28901.1 - 0.00015 22.0 0.0 0.61 10.4 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO28901.1 - 0.00034 20.7 1.1 0.28 11.4 0.1 3.1 3 0 0 3 3 3 2 Dockerin type I domain EF-hand_4 PF12763.7 KOO28901.1 - 0.0011 18.9 1.3 0.034 14.1 0.5 2.4 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EspA PF03433.13 KOO28901.1 - 0.016 15.1 0.1 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 EspA-like secreted protein UPF0154 PF03672.13 KOO28901.1 - 0.021 14.9 0.0 0.51 10.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) tRNA_synt_1c_R1 PF04558.15 KOO28901.1 - 0.071 13.1 0.2 1.3 9.0 0.0 2.1 1 1 1 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 MotA_activ PF09114.10 KOO28901.1 - 0.071 13.2 0.3 1.2 9.3 0.0 2.4 2 1 0 2 2 2 0 Transcription factor MotA, activation domain DUF2267 PF10025.9 KOO28901.1 - 0.14 12.5 0.0 0.73 10.1 0.0 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) Guanylate_cyc_2 PF09778.9 KOO28902.1 - 2.8e-46 157.5 0.0 3.2e-46 157.3 0.0 1.0 1 0 0 1 1 1 1 Guanylylate cyclase Ank_2 PF12796.7 KOO28903.1 - 7e-45 151.5 3.6 4.9e-13 49.5 0.0 5.6 3 3 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO28903.1 - 4.6e-42 141.9 3.6 5.1e-08 33.3 0.1 9.0 4 2 6 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.30 KOO28903.1 - 5.7e-36 121.4 11.9 1.5e-06 28.3 0.2 10.2 10 0 0 10 10 10 7 Ankyrin repeat Ank_3 PF13606.6 KOO28903.1 - 8.4e-33 108.7 4.1 0.0006 20.1 0.1 10.0 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 KOO28903.1 - 1.2e-29 101.9 16.2 1.5e-05 25.2 0.2 7.5 5 3 4 9 9 9 7 Ankyrin repeats (many copies) JmjC PF02373.22 KOO28904.1 - 1.3e-06 28.8 0.0 2.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 KOO28904.1 - 0.00062 19.5 0.0 0.0023 17.7 0.0 1.8 1 1 0 1 1 1 1 Cupin-like domain F-box PF00646.33 KOO28905.1 - 0.00015 21.6 0.1 0.00027 20.7 0.1 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOO28905.1 - 0.0046 16.8 0.2 0.015 15.2 0.3 1.8 2 0 0 2 2 2 1 F-box-like FabA PF07977.13 KOO28906.1 - 4.2e-33 113.9 0.2 5.2e-33 113.6 0.2 1.1 1 0 0 1 1 1 1 FabA-like domain MaoC_dehydratas PF01575.19 KOO28906.1 - 0.013 15.1 0.1 0.024 14.2 0.1 1.5 1 0 0 1 1 1 0 MaoC like domain MaoC_dehydrat_N PF13452.6 KOO28906.1 - 0.11 12.6 0.0 0.32 11.1 0.0 1.8 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase Methyltransf_25 PF13649.6 KOO28907.1 - 6.1e-08 33.3 0.0 1.2e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO28907.1 - 3.2e-07 30.3 0.0 4.5e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO28907.1 - 4.7e-07 29.5 0.0 7.2e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 KOO28907.1 - 1.2e-06 29.0 0.0 2.7e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO28907.1 - 7.1e-05 22.7 0.0 0.00014 21.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO28907.1 - 0.0001 21.9 0.1 0.00017 21.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5 PF05185.16 KOO28907.1 - 0.00076 19.4 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_24 PF13578.6 KOO28907.1 - 0.0015 19.5 0.1 0.013 16.5 0.1 2.4 2 1 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KOO28907.1 - 0.0028 17.3 0.0 0.0055 16.4 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 TehB PF03848.14 KOO28907.1 - 0.0076 15.7 0.0 0.019 14.4 0.0 1.6 1 1 1 2 2 2 1 Tellurite resistance protein TehB Methyltransf_16 PF10294.9 KOO28907.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Met_10 PF02475.16 KOO28907.1 - 0.041 13.6 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein FtsJ PF01728.19 KOO28907.1 - 0.083 13.0 0.1 0.14 12.3 0.1 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_12 PF08242.12 KOO28907.1 - 0.11 13.3 0.0 0.21 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 KOO28907.1 - 0.19 11.7 0.0 0.3 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 KOO28907.1 - 0.2 11.6 0.0 0.31 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain ARL2_Bind_BART PF11527.8 KOO28909.1 - 3.9e-42 143.0 0.0 1.1e-28 99.6 0.0 2.4 2 0 0 2 2 2 2 The ARF-like 2 binding protein BART DUF4395 PF14340.6 KOO28909.1 - 0.039 14.3 0.3 0.092 13.1 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4395) PelD_GGDEF PF16963.5 KOO28910.1 - 0.04 13.7 0.4 0.11 12.3 0.4 1.8 1 1 0 1 1 1 0 PelD GGDEF domain EutC PF05985.11 KOO28910.1 - 0.06 12.6 0.1 0.097 12.0 0.1 1.3 1 0 0 1 1 1 0 Ethanolamine ammonia-lyase light chain (EutC) Pkinase PF00069.25 KOO28911.1 - 1.1e-42 146.3 0.0 3.6e-42 144.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28911.1 - 7.1e-22 77.9 0.0 1e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO28911.1 - 2.1e-06 27.8 5.2 3.7e-05 23.8 0.1 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family NTP_transferase PF00483.23 KOO28911.1 - 0.098 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyl transferase NAD_binding_2 PF03446.15 KOO28912.1 - 8.3e-35 120.3 0.0 1.4e-34 119.6 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KOO28912.1 - 1e-19 70.9 3.4 1.8e-19 70.2 3.4 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 KOO28912.1 - 4e-05 24.1 0.0 0.00015 22.3 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent IF2_N PF04760.15 KOO28912.1 - 0.087 12.7 0.1 0.25 11.2 0.1 1.8 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region CRAL_TRIO PF00650.20 KOO28913.1 - 7.3e-21 74.5 0.0 1.2e-20 73.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Methyltransf_21 PF05050.12 KOO28914.1 - 1.4e-05 25.2 0.0 1.5e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Ribosomal_L28 PF00830.19 KOO28915.1 - 3.7e-20 71.9 2.5 4.8e-20 71.5 2.5 1.2 1 0 0 1 1 1 1 Ribosomal L28 family CR6_interact PF10147.9 KOO28916.1 - 0.019 14.7 0.1 0.023 14.4 0.1 1.0 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Glyco_hydro_39 PF01229.17 KOO28918.1 - 9.4e-51 172.9 0.0 1.4e-37 129.5 0.0 3.0 2 1 1 3 3 3 3 Glycosyl hydrolases family 39 Myotub-related PF06602.14 KOO28919.1 - 2.4e-125 418.1 0.0 3.2e-125 417.7 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GAF PF01590.26 KOO28919.1 - 0.012 16.2 0.1 0.24 12.0 0.0 2.7 3 0 0 3 3 3 0 GAF domain Y_phosphatase3 PF13350.6 KOO28919.1 - 0.073 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family bZIP_2 PF07716.15 KOO28919.1 - 0.13 12.4 2.0 0.22 11.6 2.0 1.4 1 0 0 1 1 1 0 Basic region leucine zipper bZIP_1 PF00170.21 KOO28919.1 - 0.16 12.1 0.5 0.3 11.2 0.5 1.4 1 0 0 1 1 1 0 bZIP transcription factor DUF4554 PF15091.6 KOO28919.1 - 0.35 9.7 2.8 5.7 5.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4554) DUF3138 PF11336.8 KOO28919.1 - 5.8 5.4 7.2 8.4 4.9 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Sulfate_transp PF00916.20 KOO28920.1 - 1.3e-76 257.8 31.2 1.7e-76 257.5 31.2 1.1 1 0 0 1 1 1 1 Sulfate permease family PARP PF00644.20 KOO28921.1 - 4.3e-12 46.0 0.0 6.2e-12 45.5 0.0 1.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PP2C PF00481.21 KOO28923.1 - 9.2e-33 113.9 0.0 1.4e-32 113.3 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO28923.1 - 0.00068 19.3 2.0 0.00068 19.3 2.0 2.2 2 1 0 2 2 2 1 Protein phosphatase 2C Bap31_Bap29_C PF18035.1 KOO28925.1 - 0.025 14.6 0.2 0.025 14.6 0.2 5.0 2 1 1 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Metallophos PF00149.28 KOO28927.1 - 6.9e-06 26.7 0.1 1.3e-05 25.8 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO28927.1 - 0.0025 18.0 0.2 0.029 14.6 0.1 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain TRP PF06011.12 KOO28928.1 - 0.0014 17.4 2.4 0.0052 15.6 2.4 1.9 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel DUF2615 PF11027.8 KOO28928.1 - 0.19 11.9 0.0 1.1 9.4 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) DUF5472 PF17566.2 KOO28928.1 - 7.7 6.5 10.4 7.9 6.5 0.1 3.7 4 0 0 4 4 4 0 Family of unknown function (DUF5472) CbtA PF09490.10 KOO28929.1 - 2e-34 119.4 13.6 2e-34 119.4 13.6 5.5 4 2 0 4 4 4 1 Probable cobalt transporter subunit (CbtA) HMMR_C PF15908.5 KOO28929.1 - 1.3e-06 28.8 3.6 1.3e-06 28.8 3.6 4.4 5 1 1 6 6 6 1 Hyaluronan mediated motility receptor C-terminal SMP_2 PF10144.9 KOO28929.1 - 0.013 15.1 2.0 0.022 14.4 0.8 2.1 2 0 0 2 2 2 0 Bacterial virulence factor haemolysin Sortase PF04203.13 KOO28929.1 - 0.11 12.3 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 Sortase domain HALZ PF02183.18 KOO28929.1 - 6.8 7.0 12.9 1.3 9.3 1.2 4.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper Pyrophosphatase PF00719.19 KOO28930.1 - 8e-42 142.8 0.0 9.1e-42 142.6 0.0 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase EF-hand_1 PF00036.32 KOO28931.1 - 7.6e-19 65.8 12.5 1.4e-05 24.3 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO28931.1 - 6.2e-18 65.0 8.4 4.8e-08 33.3 0.1 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO28931.1 - 6e-17 60.1 10.2 7.8e-06 25.4 0.3 4.4 3 1 1 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO28931.1 - 5.2e-11 41.5 12.0 0.0014 18.0 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO28931.1 - 2e-10 40.4 8.7 0.00042 20.1 0.1 4.5 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO28931.1 - 0.00013 22.3 3.4 0.24 11.7 0.0 2.6 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 KOO28931.1 - 0.0045 15.6 0.0 0.73 8.3 0.0 2.0 2 0 0 2 2 2 2 Family of unknown function (DUF5580) DUF2666 PF10869.8 KOO28931.1 - 0.021 15.0 0.6 0.06 13.6 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) EF-hand_4 PF12763.7 KOO28931.1 - 0.15 12.0 3.8 1.5 8.8 0.3 3.2 3 2 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO28931.1 - 8.2 6.4 6.7 6.7 6.7 0.6 2.9 4 0 0 4 4 4 0 EF hand ChAPs PF09295.10 KOO28932.1 - 2.1e-19 69.8 0.0 4.9e-12 45.6 0.0 2.2 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 KOO28932.1 - 0.14 12.7 14.7 0.47 11.0 0.5 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28932.1 - 1.9 9.5 26.3 1.1 10.2 1.8 6.0 4 1 1 5 5 5 0 Tetratricopeptide repeat SLATT_1 PF18181.1 KOO28933.1 - 0.0053 16.7 1.1 0.0084 16.0 0.0 2.0 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain 1 DUF4231 PF14015.6 KOO28933.1 - 0.015 15.7 2.9 0.017 15.6 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) EGF_2 PF07974.13 KOO28934.1 - 6.8e-07 29.5 29.3 0.00081 19.7 12.7 2.4 2 0 0 2 2 2 2 EGF-like domain NQRA_SLBB PF11973.8 KOO28934.1 - 0.087 13.5 0.1 3.1 8.5 0.0 2.6 2 0 0 2 2 2 0 NQRA C-terminal domain EGF_alliinase PF04863.13 KOO28934.1 - 3.2 8.2 25.2 0.23 11.9 7.5 3.3 1 1 1 2 2 2 0 Alliinase EGF-like domain Laminin_EGF PF00053.24 KOO28934.1 - 3.3 7.9 19.6 3.1 8.0 5.4 2.4 1 1 1 2 2 2 0 Laminin EGF domain EGF_Tenascin PF18720.1 KOO28934.1 - 9.7 6.4 25.1 1.3 9.2 10.8 2.6 2 0 0 2 2 2 0 Tenascin EGF domain Met_gamma_lyase PF06838.11 KOO28935.1 - 2.2e-144 480.9 0.0 2.5e-144 480.8 0.0 1.0 1 0 0 1 1 1 1 Methionine gamma-lyase PDZ_6 PF17820.1 KOO28935.1 - 0.047 13.5 0.0 0.34 10.8 0.0 2.4 3 0 0 3 3 3 0 PDZ domain Kinesin PF00225.23 KOO28936.1 - 9.2e-109 363.4 0.1 1.3e-108 362.9 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO28936.1 - 2.2e-26 92.6 0.1 3.8e-26 91.8 0.1 1.4 1 0 0 1 1 1 1 Microtubule binding Choline_transpo PF04515.12 KOO28937.1 - 4.6e-47 160.8 39.6 6e-47 160.4 34.8 2.1 2 0 0 2 2 2 2 Plasma-membrane choline transporter PspC PF04024.12 KOO28938.1 - 0.086 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 PspC domain Nuc_sug_transp PF04142.15 KOO28939.1 - 1.1e-91 307.4 10.8 1.2e-91 307.1 10.8 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO28939.1 - 1.5e-05 25.2 20.9 0.0003 21.0 2.5 2.6 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO28939.1 - 2.4e-05 23.7 5.1 4.3e-05 22.9 5.1 1.3 1 0 0 1 1 1 1 UAA transporter family CRT-like PF08627.10 KOO28939.1 - 0.00091 18.3 1.0 0.00091 18.3 1.0 1.9 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like Phage_holin_5_2 PF16079.5 KOO28939.1 - 0.54 10.6 8.4 0.61 10.5 0.9 3.0 2 1 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V DUF4342 PF14242.6 KOO28939.1 - 6.9 6.7 5.5 42 4.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4342) SET PF00856.28 KOO28941.1 - 8.3e-20 71.8 0.1 3e-19 70.1 0.1 1.9 1 1 0 1 1 1 1 SET domain PHD PF00628.29 KOO28941.1 - 8.6e-14 51.2 32.4 6.9e-06 25.9 7.2 3.8 3 0 0 3 3 3 3 PHD-finger AWS PF17907.1 KOO28941.1 - 2.7e-08 33.7 5.3 1.2e-07 31.6 5.3 2.2 1 0 0 1 1 1 1 AWS domain MBT PF02820.18 KOO28941.1 - 7.8e-08 32.6 0.2 0.0013 19.1 0.0 2.7 2 0 0 2 2 2 2 mbt repeat Tudor_4 PF18358.1 KOO28941.1 - 0.00014 21.3 4.4 0.00021 20.8 0.5 2.4 2 0 0 2 2 2 1 Histone methyltransferase Tudor domain PHD_2 PF13831.6 KOO28941.1 - 0.00033 20.1 13.5 0.0015 18.0 2.2 3.1 2 0 0 2 2 2 2 PHD-finger Tudor-knot PF11717.8 KOO28941.1 - 0.15 12.0 2.1 9.2 6.2 0.0 2.7 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain zf-HC5HC2H PF13771.6 KOO28941.1 - 0.61 10.4 46.0 0.085 13.1 7.3 4.2 3 1 1 4 4 4 0 PHD-like zinc-binding domain DUF4336 PF14234.6 KOO28942.1 - 9.8e-72 241.8 0.0 7.7e-49 166.6 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4336) PDZ_6 PF17820.1 KOO28943.1 - 9e-06 25.4 0.0 1.7e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Mss4 PF04421.13 KOO28943.1 - 0.00026 21.1 0.0 0.0004 20.5 0.0 1.3 1 0 0 1 1 1 1 Mss4 protein PDZ PF00595.24 KOO28943.1 - 0.0029 17.9 0.0 0.0051 17.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO28943.1 - 0.015 15.6 0.1 0.031 14.6 0.1 1.5 1 0 0 1 1 1 0 PDZ domain EF-hand_1 PF00036.32 KOO28944.1 - 4.1e-23 79.2 4.2 0.00017 20.9 0.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO28944.1 - 7.5e-23 78.5 4.0 6.2e-05 22.6 0.1 4.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO28944.1 - 1.9e-20 73.1 8.2 9.9e-09 35.5 0.1 2.8 1 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO28944.1 - 2.7e-15 55.9 6.6 0.0054 16.6 0.0 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO28944.1 - 3.8e-13 48.3 3.1 0.036 13.6 0.0 4.2 4 0 0 4 4 4 4 EF hand Armet PF10208.9 KOO28944.1 - 0.0003 20.8 0.1 0.0012 18.7 0.0 2.0 1 1 1 2 2 2 1 Degradation arginine-rich protein for mis-folding EF-hand_10 PF14788.6 KOO28944.1 - 0.0009 19.1 1.5 7.5 6.5 0.0 3.7 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 KOO28944.1 - 0.002 18.4 0.7 0.21 11.9 0.0 2.8 2 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO28944.1 - 0.0083 17.0 0.0 4.3 8.3 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO28944.1 - 0.11 12.5 3.3 6.1 6.8 0.1 3.2 1 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand CPL PF08144.11 KOO28945.1 - 1.4e-17 64.3 0.0 7.2e-16 58.8 0.0 3.2 3 1 0 3 3 3 1 CPL (NUC119) domain Patatin PF01734.22 KOO28945.1 - 0.00065 19.9 0.8 0.00065 19.9 0.8 2.3 2 1 0 2 2 2 1 Patatin-like phospholipase SATase_N PF06426.14 KOO28945.1 - 0.15 12.4 2.5 1.7 9.1 0.0 3.0 3 0 0 3 3 3 0 Serine acetyltransferase, N-terminal AAA_16 PF13191.6 KOO28946.1 - 0.01 16.2 0.1 0.046 14.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain GRP PF07172.11 KOO28946.1 - 0.043 14.5 5.0 0.11 13.2 5.0 1.6 1 0 0 1 1 1 0 Glycine rich protein family Peptidase_C48 PF02902.19 KOO28947.1 - 3.9e-39 134.7 0.1 7.6e-38 130.5 0.1 2.6 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain U79_P34 PF03064.16 KOO28947.1 - 0.46 9.8 4.5 3.1 7.1 0.1 3.1 2 2 1 3 3 3 0 HSV U79 / HCMV P34 U-box PF04564.15 KOO28948.1 - 5.8e-13 48.8 0.0 1.6e-12 47.4 0.0 1.8 2 0 0 2 2 2 1 U-box domain FemAB PF02388.16 KOO28949.1 - 0.28 10.0 2.7 0.42 9.4 2.7 1.2 1 0 0 1 1 1 0 FemAB family ABC_tran_CTD PF16326.5 KOO28949.1 - 3.1 8.1 14.1 2.8 8.3 1.0 3.3 3 0 0 3 3 3 0 ABC transporter C-terminal domain Ribosomal_L23 PF00276.20 KOO28950.1 - 5.7e-14 52.2 2.7 5.7e-14 52.2 2.7 2.6 2 1 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 KOO28950.1 - 5.2e-11 42.6 15.1 1.3e-10 41.3 15.1 1.8 1 1 0 1 1 1 1 Ribosomal protein L23, N-terminal domain PAN_4 PF14295.6 KOO28951.1 - 1.5e-05 24.8 8.2 6.2e-05 22.8 8.2 2.1 1 1 0 1 1 1 1 PAN domain APG6_N PF17675.1 KOO28952.1 - 0.015 15.8 2.4 0.015 15.8 2.4 9.8 3 3 4 7 7 7 0 Apg6 coiled-coil region Aa_trans PF01490.18 KOO28954.1 - 2.1e-44 151.9 13.2 2.7e-44 151.5 13.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOO28954.1 - 1.5e-05 24.2 9.9 1.5e-05 24.2 9.9 1.5 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family Porin_5 PF16930.5 KOO28955.1 - 0.31 9.5 1.0 0.49 8.8 1.0 1.2 1 0 0 1 1 1 0 Putative porin DUF1192 PF06698.11 KOO28955.1 - 2.3 8.3 0.0 2.3 8.3 0.0 4.2 4 1 0 4 4 4 0 Protein of unknown function (DUF1192) Hydrolase_6 PF13344.6 KOO28956.1 - 1.7e-15 57.0 0.0 4e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO28956.1 - 1.7e-13 50.4 0.0 3.2e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KOO28956.1 - 4.8e-07 30.0 0.0 0.00023 21.3 0.0 2.1 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO28956.1 - 5e-06 27.0 0.0 0.011 16.1 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase WD40 PF00400.32 KOO28957.1 - 2.6e-14 53.4 0.0 0.08 13.8 0.0 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat PCP_red PF08369.10 KOO28957.1 - 0.0052 17.0 0.2 0.014 15.6 0.2 1.7 1 0 0 1 1 1 1 Proto-chlorophyllide reductase 57 kD subunit ANAPC4_WD40 PF12894.7 KOO28957.1 - 0.0094 16.2 0.0 1 9.7 0.0 3.8 4 2 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain UPRTase PF14681.6 KOO28957.1 - 0.2 11.1 0.0 0.36 10.2 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase RNaseH_like PF04308.12 KOO28958.1 - 1.2e-14 54.5 0.1 8.8e-13 48.4 0.0 2.2 2 0 0 2 2 2 2 Ribonuclease H-like ATPgrasp_ST PF14397.6 KOO28959.1 - 5.9e-05 22.4 0.0 0.00039 19.7 0.0 1.9 1 1 1 2 2 2 1 Sugar-transfer associated ATP-grasp PCI PF01399.27 KOO28960.1 - 2.1e-18 66.8 0.2 7.4e-18 65.0 0.2 2.0 1 0 0 1 1 1 1 PCI domain TPR_7 PF13176.6 KOO28960.1 - 0.00053 19.8 4.5 4 7.7 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28960.1 - 0.0094 16.7 0.0 2 9.5 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat RPN6_N PF18055.1 KOO28960.1 - 0.032 14.6 5.6 1.5 9.2 1.2 2.8 1 1 2 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_6 PF13174.6 KOO28960.1 - 0.13 12.9 1.2 14 6.5 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1910 PF08928.10 KOO28960.1 - 0.19 11.7 4.4 2.5 8.1 2.8 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF1910) Imm70 PF15601.6 KOO28960.1 - 0.38 10.3 2.5 0.78 9.3 0.1 2.5 3 1 0 3 3 3 0 Immunity protein 70 Nudix_N PF12535.8 KOO28960.1 - 1.1 9.0 0.0 1.1 9.0 0.0 2.8 3 0 0 3 3 3 0 Hydrolase of X-linked nucleoside diphosphate N terminal TetR_C_19 PF17924.1 KOO28960.1 - 3.6 8.2 9.3 5.6 7.6 0.1 3.1 3 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain ABC_membrane PF00664.23 KOO28961.1 - 2.8e-06 27.2 0.1 2.8e-06 27.2 0.1 2.7 3 0 0 3 3 3 1 ABC transporter transmembrane region Ribosomal_L3 PF00297.22 KOO28962.1 - 3.3e-171 569.3 9.1 3.8e-171 569.1 9.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 DUF5089 PF17002.5 KOO28962.1 - 0.039 13.8 0.5 0.08 12.8 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) EF-hand_7 PF13499.6 KOO28963.1 - 2.8e-24 85.4 0.2 1.3e-09 38.3 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO28963.1 - 3.4e-23 79.6 0.0 6.1e-05 22.6 0.0 5.4 5 0 0 5 5 5 5 EF-hand domain EF-hand_1 PF00036.32 KOO28963.1 - 8.7e-21 71.9 0.0 0.00027 20.3 0.2 5.3 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.6 KOO28963.1 - 1.1e-14 54.0 0.3 1e-05 25.3 0.4 3.9 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO28963.1 - 8.5e-12 44.0 0.0 0.064 12.8 0.0 4.4 4 0 0 4 4 4 4 EF hand DUF2222 PF09984.9 KOO28964.1 - 0.0019 18.1 0.0 0.013 15.4 0.0 1.9 2 0 0 2 2 2 1 Uncharacterised signal transduction histidine kinase domain (DUF2222) Arm PF00514.23 KOO28965.1 - 2.1e-31 106.9 33.0 8.4e-07 28.8 0.6 6.6 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat U-box PF04564.15 KOO28965.1 - 1.9e-10 40.8 0.0 3.5e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO28965.1 - 1.6e-05 24.6 0.0 3.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO28965.1 - 0.0042 17.2 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Atx10homo_assoc PF09759.9 KOO28965.1 - 0.02 14.9 0.2 0.76 9.8 0.0 2.9 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain zf-RING_UBOX PF13445.6 KOO28965.1 - 0.043 13.9 0.0 0.088 12.8 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger CoA_binding_2 PF13380.6 KOO28965.1 - 0.17 12.4 11.9 8.5 6.9 0.1 4.7 1 1 4 5 5 5 0 CoA binding domain MORN PF02493.20 KOO28966.1 - 2.8e-61 199.9 111.6 1.4e-07 31.0 1.4 16.4 16 0 0 16 16 16 13 MORN repeat Calreticulin PF00262.18 KOO28966.1 - 0.88 8.4 6.9 3.3 6.5 0.3 2.5 3 0 0 3 3 3 0 Calreticulin family CdiI_3 PF18616.1 KOO28966.1 - 1.3 9.0 3.4 2.2e+02 1.8 0.0 4.3 5 0 0 5 5 5 0 CDI immunity proteins HCV_NS5a_1a PF08300.13 KOO28966.1 - 4.6 7.4 13.9 4.6 7.4 0.2 5.0 4 1 0 4 4 4 0 Hepatitis C virus non-structural 5a zinc finger domain Bestrophin PF01062.21 KOO28967.1 - 8.8e-27 94.2 0.5 1.7e-26 93.3 0.5 1.4 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF21 PF01595.20 KOO28967.1 - 3.1e-26 92.1 0.2 7e-26 91.0 0.2 1.6 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain DUF2626 PF11117.8 KOO28967.1 - 0.51 11.1 2.9 0.5 11.1 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2626) DUF3110 PF11360.8 KOO28968.1 - 6.5e-13 48.7 0.0 9.7e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3110) DUF2706 PF10913.8 KOO28968.1 - 0.018 14.8 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) SelR PF01641.18 KOO28969.1 - 2.7e-08 33.9 0.1 0.00067 19.7 0.0 2.1 1 1 1 2 2 2 2 SelR domain Glyco_transf_8 PF01501.20 KOO28971.1 - 4.5e-35 121.4 0.0 6.4e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 WW PF00397.26 KOO28973.1 - 1.2e-14 54.1 0.0 3.5e-05 23.8 0.0 3.6 3 0 0 3 3 3 3 WW domain EF-hand_5 PF13202.6 KOO28973.1 - 2.5e-08 33.1 2.2 6.3e-05 22.3 0.1 3.2 4 0 0 4 4 4 2 EF hand EF-hand_1 PF00036.32 KOO28973.1 - 7.8e-08 31.3 2.6 0.012 15.1 0.0 3.4 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KOO28973.1 - 2.6e-06 26.9 5.6 0.0036 17.1 0.1 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 KOO28973.1 - 0.0009 19.6 4.6 0.001 19.5 0.7 3.0 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO28973.1 - 0.014 15.2 5.6 0.43 10.5 0.1 3.4 4 0 0 4 4 4 0 EF-hand domain pair IQ PF00612.27 KOO28973.1 - 0.016 14.9 2.6 1.9 8.5 0.1 2.4 2 0 0 2 2 2 0 IQ calmodulin-binding motif FAST_1 PF06743.15 KOO28974.1 - 6.3e-06 26.0 0.5 0.18 11.7 0.0 3.5 3 1 2 5 5 5 3 FAST kinase-like protein, subdomain 1 ImpE PF07024.13 KOO28974.1 - 0.27 11.3 1.5 13 5.9 0.1 3.2 2 1 2 4 4 4 0 ImpE protein ATG16 PF08614.11 KOO28975.1 - 0.00068 19.9 4.8 0.00068 19.9 4.8 2.0 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) STI1 PF17830.1 KOO28975.1 - 0.041 13.8 0.0 0.17 11.8 0.0 2.1 1 0 0 1 1 1 0 STI1 domain ABC_tran_CTD PF16326.5 KOO28975.1 - 0.043 14.1 4.6 3.4 8.0 0.0 4.0 3 1 0 3 3 3 0 ABC transporter C-terminal domain CENP-F_leu_zip PF10473.9 KOO28975.1 - 0.09 12.8 3.2 0.26 11.3 0.8 2.5 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BNIP3 PF06553.12 KOO28975.1 - 0.12 12.1 0.6 0.27 10.9 0.6 1.6 1 0 0 1 1 1 0 BNIP3 DUF1319 PF07028.11 KOO28975.1 - 0.14 12.4 0.0 18 5.6 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) APG6_N PF17675.1 KOO28975.1 - 3.6 8.1 8.5 1.4 9.5 4.1 2.3 2 1 1 3 3 3 0 Apg6 coiled-coil region TACC_C PF05010.14 KOO28975.1 - 3.6 7.3 5.6 0.33 10.7 0.8 1.7 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Nnf1 PF03980.14 KOO28975.1 - 8.8 6.8 11.3 0.59 10.5 1.8 3.3 3 1 1 4 4 4 0 Nnf1 CLASP_N PF12348.8 KOO28977.1 - 1.4e-07 31.3 0.2 5.8e-07 29.3 0.0 2.1 3 0 0 3 3 3 1 CLASP N terminal PseudoU_synth_1 PF01416.20 KOO28977.1 - 0.083 13.4 2.0 0.37 11.3 0.6 2.5 2 0 0 2 2 2 0 tRNA pseudouridine synthase HEAT PF02985.22 KOO28977.1 - 0.11 12.8 1.1 4.2 7.9 0.1 3.5 2 0 0 2 2 2 0 HEAT repeat DUF3869 PF12985.7 KOO28977.1 - 0.38 11.2 6.9 8 6.9 6.9 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3869) Chon_Sulph_att PF06566.11 KOO28977.1 - 0.49 10.2 0.0 0.49 10.2 0.0 3.5 4 1 0 4 4 4 0 Chondroitin sulphate attachment domain Pkinase PF00069.25 KOO28978.1 - 5.8e-44 150.4 0.0 2.3e-42 145.2 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO28978.1 - 1.5e-24 86.7 0.0 2.9e-24 85.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO28978.1 - 0.0002 21.4 0.0 0.33 10.8 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family IQ PF00612.27 KOO28978.1 - 0.0011 18.5 0.6 0.0034 17.0 0.6 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Kdo PF06293.14 KOO28978.1 - 0.035 13.5 0.0 0.071 12.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Neur_chan_memb PF02932.16 KOO28979.1 - 3.4e-05 24.0 5.7 8e-05 22.8 3.6 2.0 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DUF179 PF02622.15 KOO28980.1 - 6.7e-18 65.2 0.1 2.7e-17 63.2 0.1 1.9 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 Sugar_tr PF00083.24 KOO28981.1 - 1.8e-80 271.1 13.7 3.2e-80 270.2 13.7 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO28981.1 - 1.5e-14 53.7 62.2 7.9e-13 48.0 39.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Chloroa_b-bind PF00504.21 KOO28982.1 - 5.3e-27 95.3 0.3 1.2e-25 90.9 0.3 2.2 1 1 0 1 1 1 1 Chlorophyll A-B binding protein TFIIIC_delta PF12657.7 KOO28982.1 - 0.16 11.8 0.0 0.75 9.7 0.0 1.8 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term AAA_9 PF12781.7 KOO28983.1 - 2.7e-66 222.8 0.0 2.7e-66 222.8 0.0 2.4 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 KOO28983.1 - 3.5e-55 187.1 0.0 7.9e-54 182.7 0.0 2.9 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 AAA_6 PF12774.7 KOO28983.1 - 5.9e-39 133.9 0.5 3.8e-38 131.3 0.1 2.5 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region AAA_lid_11 PF18198.1 KOO28983.1 - 3.6e-38 131.0 0.0 1.3e-37 129.1 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO28983.1 - 1.5e-34 118.6 3.6 4.3e-33 113.9 0.1 3.9 4 0 0 4 4 4 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 KOO28983.1 - 2.5e-33 115.0 0.0 9.4e-24 84.0 0.0 4.5 4 0 0 4 4 4 3 AAA domain (dynein-related subfamily) MT PF12777.7 KOO28983.1 - 1.3e-27 96.7 6.8 2.1e-27 96.1 6.8 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_C PF18199.1 KOO28983.1 - 6.6e-27 94.5 0.0 1.6e-26 93.2 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 KOO28983.1 - 4.3e-25 88.3 3.6 1.2e-22 80.3 0.0 3.4 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_16 PF13191.6 KOO28983.1 - 3.7e-08 33.9 3.9 0.018 15.4 0.0 5.4 5 0 0 5 5 4 2 AAA ATPase domain AAA_22 PF13401.6 KOO28983.1 - 2.8e-05 24.4 2.1 0.53 10.6 0.0 4.5 4 1 0 4 4 4 2 AAA domain IstB_IS21 PF01695.17 KOO28983.1 - 4.1e-05 23.4 0.2 0.044 13.5 0.0 2.9 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_lid_1 PF17857.1 KOO28983.1 - 8.1e-05 22.8 0.0 0.00021 21.4 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RsgA_GTPase PF03193.16 KOO28983.1 - 9.8e-05 22.3 1.4 0.16 11.9 0.0 4.0 4 0 0 4 4 3 1 RsgA GTPase AAA PF00004.29 KOO28983.1 - 0.00024 21.5 0.2 2.2 8.7 0.0 3.4 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KOO28983.1 - 0.00033 20.6 0.0 0.1 12.5 0.0 3.2 3 0 0 3 3 3 1 Rad17 P-loop domain ABC_tran PF00005.27 KOO28983.1 - 0.00035 21.1 4.1 0.067 13.7 0.0 4.1 4 1 0 4 4 4 1 ABC transporter Guanylate_kin PF00625.21 KOO28983.1 - 0.00065 19.4 0.2 0.14 11.8 0.0 3.4 3 0 0 3 3 3 1 Guanylate kinase AAA_25 PF13481.6 KOO28983.1 - 0.0027 17.3 0.0 1.3 8.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KOO28983.1 - 0.0033 17.4 0.1 3.4 7.6 0.0 3.0 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 KOO28983.1 - 0.0075 16.2 0.0 4.4 7.1 0.0 2.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_29 PF13555.6 KOO28983.1 - 0.0082 15.9 0.0 0.63 9.8 0.0 3.1 3 0 0 3 3 3 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 KOO28983.1 - 0.01 16.2 0.0 0.23 11.9 0.0 2.5 2 0 0 2 2 2 0 RNA helicase ERM PF00769.19 KOO28983.1 - 0.014 15.2 24.8 0.44 10.3 2.7 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Mg_chelatase PF01078.21 KOO28983.1 - 0.024 14.0 0.1 8.6 5.7 0.0 2.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 KOO28983.1 - 0.024 14.9 0.0 3.8 7.7 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KOO28983.1 - 0.025 14.7 0.3 4.8 7.3 0.0 3.0 2 0 0 2 2 2 0 AAA domain Exonuc_VII_L PF02601.15 KOO28983.1 - 0.033 13.8 13.7 0.42 10.1 0.4 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit AAA_23 PF13476.6 KOO28983.1 - 0.26 11.8 0.0 0.26 11.8 0.0 3.8 4 0 0 4 4 3 0 AAA domain Fez1 PF06818.15 KOO28983.1 - 0.35 11.3 15.1 0.86 10.0 0.9 2.6 2 0 0 2 2 2 0 Fez1 DUF3450 PF11932.8 KOO28983.1 - 0.43 9.9 17.8 1.2 8.4 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) ING PF12998.7 KOO28983.1 - 0.55 10.8 3.7 2.3 8.9 1.0 2.8 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DUF1664 PF07889.12 KOO28983.1 - 0.58 10.2 10.6 3.2 7.8 2.2 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Arf PF00025.21 KOO28983.1 - 0.98 8.9 2.9 1.4 8.3 0.0 2.5 3 0 0 3 3 2 0 ADP-ribosylation factor family T3SSipB PF16535.5 KOO28983.1 - 1.1 9.8 15.8 1.8 9.0 6.9 2.8 2 0 0 2 2 2 0 Type III cell invasion protein SipB Phage_GPO PF05929.11 KOO28983.1 - 1.2 8.7 7.8 4.4 6.9 3.5 2.4 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase OmpH PF03938.14 KOO28983.1 - 3.1 8.1 21.3 22 5.4 0.3 2.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 KOO28983.1 - 5 6.3 10.1 10 5.3 0.2 2.2 2 0 0 2 2 2 0 TMPIT-like protein RPGR1_C PF18111.1 KOO28986.1 - 6.4e-05 22.9 0.0 0.00066 19.6 0.0 2.3 2 0 0 2 2 2 1 Retinitis pigmentosa G-protein regulator interacting C-terminal NT-C2 PF10358.9 KOO28986.1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins LIP PF03583.14 KOO28986.1 - 0.069 12.5 0.2 0.14 11.4 0.2 1.4 1 0 0 1 1 1 0 Secretory lipase MFS_1 PF07690.16 KOO28987.1 - 5.2e-06 25.6 7.8 1.8e-05 23.9 7.9 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily MARVEL PF01284.23 KOO28987.1 - 0.0076 16.3 5.4 0.63 10.1 1.0 2.9 3 0 0 3 3 3 2 Membrane-associating domain SCAB-Ig PF16709.5 KOO28988.1 - 0.00012 22.0 0.0 0.0002 21.4 0.0 1.4 1 0 0 1 1 1 1 Ig domain of plant-specific actin-binding protein Hydrolase_like PF13242.6 KOO28989.1 - 3.3e-11 43.1 0.0 1e-10 41.5 0.0 1.9 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 KOO28989.1 - 1.1e-09 38.3 0.0 3.2e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase EF-hand_1 PF00036.32 KOO28989.1 - 0.0024 17.3 0.3 0.2 11.3 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO28989.1 - 0.0029 17.4 0.1 0.05 13.6 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO28989.1 - 0.024 15.1 0.0 0.058 13.9 0.0 1.6 1 1 0 1 1 1 0 EF-hand domain pair PGP_phosphatase PF09419.10 KOO28989.1 - 0.074 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase EF-hand_5 PF13202.6 KOO28989.1 - 0.097 12.2 0.3 0.24 11.0 0.3 1.6 1 0 0 1 1 1 0 EF hand Hydrolase PF00702.26 KOO28989.1 - 0.13 12.5 0.0 3.1 8.0 0.1 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Golgin_A5 PF09787.9 KOO28990.1 - 0.024 14.1 22.7 0.29 10.6 1.5 3.2 3 0 0 3 3 3 0 Golgin subfamily A member 5 LRR_6 PF13516.6 KOO28990.1 - 0.069 13.2 0.8 2.3 8.5 0.1 2.9 3 0 0 3 3 3 0 Leucine Rich repeat Fez1 PF06818.15 KOO28990.1 - 0.27 11.7 27.8 0.27 11.7 9.8 3.6 3 0 0 3 3 3 0 Fez1 Filament PF00038.21 KOO28990.1 - 0.58 9.7 34.5 0.17 11.4 0.3 3.3 3 0 0 3 3 3 0 Intermediate filament protein Prefoldin_2 PF01920.20 KOO28990.1 - 0.85 9.6 7.9 0.13 12.3 1.6 2.6 1 1 0 2 2 2 0 Prefoldin subunit LCIB_C_CA PF18599.1 KOO28990.1 - 0.88 8.8 8.4 1 8.6 5.7 2.4 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases SHIPPO-rpt PF07004.12 KOO28992.1 - 9.9e-08 32.6 32.1 0.02 15.8 0.3 7.5 7 0 0 7 7 7 6 Sperm-tail PG-rich repeat FHA PF00498.26 KOO28993.1 - 0.095 13.1 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 FHA domain UvrD-helicase PF00580.21 KOO28994.1 - 1.2e-46 159.7 0.1 1.6e-26 93.6 0.0 2.4 1 1 1 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 KOO28994.1 - 2.4e-34 118.8 0.1 1.2e-33 116.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain UvrD_C PF13361.6 KOO28994.1 - 1.8e-25 90.0 0.0 3.3e-24 85.9 0.0 2.5 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 KOO28994.1 - 8e-12 45.3 0.8 8e-12 45.3 0.8 2.3 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 KOO28994.1 - 6.3e-10 38.7 0.8 8.5e-09 35.1 0.8 2.6 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 KOO28994.1 - 3e-08 33.8 1.4 4.4e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 KOO28994.1 - 3.3e-06 27.0 1.5 0.23 11.1 0.0 3.6 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KOO28994.1 - 0.02 15.2 0.4 0.069 13.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_12 PF13087.6 KOO28994.1 - 0.18 11.4 0.0 0.65 9.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Herpes_capsid PF06112.11 KOO28994.1 - 1 9.4 13.1 2.2 8.3 11.2 2.3 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein PfkB PF00294.24 KOO28995.1 - 3.3e-47 161.2 2.3 5e-47 160.7 2.3 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase AP_endonuc_2 PF01261.24 KOO28995.1 - 6.7e-17 61.6 0.0 3.4e-16 59.3 0.0 2.2 3 0 0 3 3 3 1 Xylose isomerase-like TIM barrel STAS PF01740.21 KOO28995.1 - 4.3e-10 39.3 0.1 1.4e-09 37.6 0.1 1.9 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 KOO28995.1 - 1.4e-09 37.2 19.3 1.4e-09 37.2 19.3 1.7 2 1 0 2 2 2 1 Sulfate permease family Phos_pyr_kin PF08543.12 KOO28995.1 - 5e-07 29.3 0.0 8.8e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase cNMP_binding PF00027.29 KOO28995.1 - 0.05 13.7 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain CLN3 PF02487.17 KOO28996.1 - 1.4e-46 159.4 7.8 1.6e-24 86.7 0.0 2.0 1 1 0 2 2 2 2 CLN3 protein EF-hand_1 PF00036.32 KOO28997.1 - 8.7e-20 68.7 0.1 4.6e-05 22.7 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO28997.1 - 3.7e-17 60.7 0.3 0.00029 20.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO28997.1 - 1.7e-15 57.2 5.5 2e-06 28.1 0.0 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO28997.1 - 4.9e-11 41.6 0.2 0.047 13.2 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO28997.1 - 6.5e-07 29.1 1.9 0.018 14.9 0.0 4.1 3 1 1 4 4 4 3 EF-hand domain pair TPR_12 PF13424.6 KOO28997.1 - 0.0093 16.2 6.9 0.06 13.6 1.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat EF-hand_4 PF12763.7 KOO28997.1 - 0.013 15.4 0.6 9.7 6.2 0.1 2.7 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF2201 PF09967.9 KOO28997.1 - 0.015 15.4 0.1 10 6.3 0.0 2.7 2 0 0 2 2 2 0 VWA-like domain (DUF2201) TPR_10 PF13374.6 KOO28997.1 - 0.81 9.6 8.6 8.7 6.4 0.1 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO28997.1 - 1.7 9.7 10.5 35 5.6 0.1 5.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO28997.1 - 3.5 8.5 6.8 79 4.2 0.2 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat APH PF01636.23 KOO28998.1 - 7.2e-40 137.4 0.6 7.2e-40 137.4 0.6 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Acyl-CoA_dh_1 PF00441.24 KOO28998.1 - 2.7e-30 105.6 6.4 2.7e-30 105.6 6.4 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOO28998.1 - 2.3e-13 50.8 0.0 6.2e-13 49.4 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KOO28998.1 - 3.7e-11 43.1 0.0 1.9e-10 40.8 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KOO28998.1 - 2.5e-09 37.5 7.6 2.5e-09 37.5 7.6 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain EcKinase PF02958.20 KOO28998.1 - 0.00044 19.7 0.0 0.0007 19.0 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 KOO28998.1 - 0.028 13.3 0.0 0.04 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) HTH_28 PF13518.6 KOO28998.1 - 0.28 11.4 2.0 0.89 9.7 0.9 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain Sulfatase PF00884.23 KOO28999.1 - 1.4e-22 80.5 0.0 1.9e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KOO28999.1 - 5.5e-20 72.4 0.0 9.2e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 KOO28999.1 - 0.025 14.2 0.0 0.037 13.6 0.0 1.1 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Bacteriocin_IIc PF10439.9 KOO29000.1 - 0.0048 17.0 10.2 0.062 13.4 3.0 2.3 2 0 0 2 2 2 2 Bacteriocin class II with double-glycine leader peptide Gly-zipper_YMGG PF13441.6 KOO29000.1 - 0.0094 15.7 21.7 0.037 13.8 6.5 2.6 3 0 0 3 3 3 2 YMGG-like Gly-zipper DUF5518 PF17647.1 KOO29000.1 - 0.016 15.3 4.4 1.1 9.4 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5518) DUF2530 PF10745.9 KOO29000.1 - 0.026 14.8 0.9 0.097 12.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) T2SSM PF04612.12 KOO29000.1 - 0.026 14.6 1.5 0.035 14.1 1.5 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Gly-zipper_Omp PF13488.6 KOO29000.1 - 0.08 13.0 16.3 1.2 9.1 2.0 2.5 2 0 0 2 2 2 0 Glycine zipper MSP1_C PF07462.11 KOO29000.1 - 0.17 10.6 2.8 0.16 10.6 2.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Gly-zipper_OmpA PF13436.6 KOO29000.1 - 0.32 10.8 31.7 0.079 12.8 12.7 2.9 3 0 0 3 3 3 0 Glycine-zipper domain Rrn6 PF10214.9 KOO29000.1 - 0.42 9.1 1.4 0.46 8.9 1.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1269 PF06897.12 KOO29000.1 - 0.58 10.5 5.6 13 6.2 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) Rick_17kDa_Anti PF05433.15 KOO29000.1 - 3.5 7.6 19.8 0.51 10.3 2.8 2.7 2 1 0 2 2 2 0 Glycine zipper 2TM domain Herpes_capsid PF06112.11 KOO29000.1 - 5.8 6.9 14.3 4.8 7.2 13.5 1.3 1 1 0 1 1 1 0 Gammaherpesvirus capsid protein CoatB PF10389.9 KOO29000.1 - 9.4 6.2 12.4 10 6.0 1.4 2.4 2 0 0 2 2 2 0 Bacteriophage coat protein B UvrD-helicase PF00580.21 KOO29001.1 - 4.2e-49 167.8 0.0 9.6e-49 166.6 0.0 1.6 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 KOO29001.1 - 5.1e-45 154.3 0.0 2.3e-22 79.8 0.0 2.1 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 KOO29001.1 - 1.2e-27 97.0 0.0 2.8e-27 95.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KOO29001.1 - 2.9e-11 43.0 1.2 7.2e-10 38.5 1.2 2.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 KOO29001.1 - 4.4e-07 29.8 0.3 0.038 13.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 KOO29001.1 - 1.3e-05 24.9 0.0 0.00062 19.4 0.0 2.7 2 1 1 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 KOO29001.1 - 0.00049 19.9 0.1 0.01 15.6 0.0 2.6 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase LEAP-2 PF07359.11 KOO29001.1 - 0.1 12.4 0.1 0.27 11.1 0.1 1.7 1 0 0 1 1 1 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) EF-hand_7 PF13499.6 KOO29002.1 - 0.026 15.0 0.1 0.07 13.6 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO29002.1 - 0.029 14.3 0.0 0.074 13.0 0.0 1.8 1 1 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 KOO29002.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.6 KOO29002.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 EF hand FtsJ PF01728.19 KOO29003.1 - 6e-68 228.4 0.0 6.8e-68 228.2 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF563 PF04577.14 KOO29004.1 - 6.5e-06 26.4 0.4 1.4e-05 25.3 0.4 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF563) VCBS PF13517.6 KOO29005.1 - 2e-178 579.2 214.6 1.8e-13 50.9 5.6 18.4 2 2 17 19 19 19 19 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO29005.1 - 1.6e-80 264.7 195.7 3.6e-05 23.8 1.8 19.5 19 0 0 19 19 19 19 FG-GAP repeat Dockerin_1 PF00404.18 KOO29005.1 - 1.6e-13 50.6 52.2 14 6.0 0.0 18.2 19 0 0 19 19 19 1 Dockerin type I domain HET-s_218-289 PF11558.8 KOO29005.1 - 4.1e-12 45.9 0.8 32 4.6 0.0 14.4 18 0 0 18 18 18 0 Het-s 218-289 TM_PBP2_N PF16296.5 KOO29005.1 - 2.2e-10 40.5 0.0 52 4.1 0.0 11.8 14 0 0 14 14 13 0 N-terminal of TM subunit in PBP-dependent ABC transporters Arrestin_N PF00339.29 KOO29005.1 - 1.1e-06 28.7 0.0 1.6e+02 2.3 0.0 10.4 16 0 0 16 16 16 0 Arrestin (or S-antigen), N-terminal domain DUF5001 PF16392.5 KOO29005.1 - 9.4e-05 22.2 0.0 32 4.5 0.0 7.7 9 3 3 12 12 12 0 Ig-like domain Peptidase_C41 PF05417.11 KOO29005.1 - 0.0037 17.1 13.7 14 5.5 0.0 10.7 9 5 5 16 16 16 1 Hepatitis E cysteine protease TcdB_toxin_midN PF12256.8 KOO29005.1 - 0.0063 15.9 87.3 7.7 5.8 0.1 17.8 4 4 14 19 19 19 5 Insecticide toxin TcdB middle/N-terminal region T4BSS_DotH_IcmK PF12293.8 KOO29005.1 - 0.018 14.3 0.0 31 3.7 0.0 4.7 3 3 3 6 6 6 0 Putative outer membrane core complex of type IVb secretion LpxI_N PF17930.1 KOO29005.1 - 0.43 10.5 1.7 58 3.6 0.1 5.6 12 0 0 12 12 12 0 LpxI N-terminal domain DUF3716 PF12511.8 KOO29005.1 - 0.94 9.6 3.5 2 8.5 3.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) Pkinase PF00069.25 KOO29006.1 - 6.2e-57 192.9 0.0 7.7e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29006.1 - 2.5e-42 145.0 0.0 3.3e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO29006.1 - 1.4e-06 27.9 0.1 0.0064 15.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KOO29006.1 - 0.0001 21.2 0.0 0.00017 20.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO29006.1 - 0.0018 18.3 0.0 1.6 8.6 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO29006.1 - 0.0089 15.0 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain ABC1 PF03109.16 KOO29007.1 - 1.1e-29 103.0 0.0 2.3e-29 102.0 0.0 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO29007.1 - 0.00028 20.9 0.1 0.00028 20.9 0.1 2.8 3 0 0 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO29007.1 - 0.055 12.8 0.0 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Protein kinase domain Peptidase_S10 PF00450.22 KOO29009.1 - 9e-110 367.9 2.5 1.4e-109 367.4 2.5 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase cNMP_binding PF00027.29 KOO29009.1 - 2.2e-29 101.3 0.1 8.1e-07 29.0 0.0 5.4 4 1 1 5 5 5 5 Cyclic nucleotide-binding domain Myosin_head PF00063.21 KOO29010.1 - 4e-187 623.5 0.0 5.5e-187 623.1 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) PDZ PF00595.24 KOO29010.1 - 8.4e-09 35.7 1.1 0.00085 19.6 0.0 3.8 3 1 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 KOO29010.1 - 3e-08 33.4 6.0 9.6e-06 25.4 0.3 3.3 4 0 0 4 4 4 2 PDZ domain PDZ_2 PF13180.6 KOO29010.1 - 1.9e-06 28.1 0.4 0.71 10.2 0.0 4.3 4 0 0 4 4 4 2 PDZ domain WW PF00397.26 KOO29010.1 - 6.5e-06 26.1 1.0 1.3e-05 25.2 1.0 1.5 1 0 0 1 1 1 1 WW domain AAA_16 PF13191.6 KOO29010.1 - 0.0097 16.3 0.1 0.0097 16.3 0.1 4.0 3 2 1 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 KOO29010.1 - 0.034 14.4 3.5 0.057 13.7 0.1 2.6 2 0 0 2 2 2 0 AAA domain Asp-B-Hydro_N PF05279.11 KOO29010.1 - 2.5 8.1 29.5 6.5 6.7 29.5 1.7 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Caldesmon PF02029.15 KOO29010.1 - 4.2 6.0 48.7 0.23 10.2 42.5 2.0 2 0 0 2 2 2 0 Caldesmon Metallophos PF00149.28 KOO29011.1 - 1.5e-11 45.2 0.5 2.6e-11 44.4 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 KOO29011.1 - 3.6e-08 34.1 0.2 3.6e-08 34.1 0.2 2.6 3 1 0 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C TPR_17 PF13431.6 KOO29012.1 - 2.7e-11 43.0 0.0 0.17 12.4 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO29012.1 - 4e-08 32.7 0.0 0.0046 16.7 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO29012.1 - 4.4e-08 32.6 5.8 0.027 14.6 0.0 5.9 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO29012.1 - 2.4e-06 27.3 0.1 1.7 9.1 0.0 5.4 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO29012.1 - 1.4e-05 25.5 15.4 0.0013 19.4 0.7 4.6 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO29012.1 - 0.00012 22.3 8.4 0.2 12.0 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO29012.1 - 0.00046 20.3 3.9 0.29 11.3 0.2 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO29012.1 - 0.00055 19.6 0.1 1.7 8.4 0.0 4.7 4 2 2 6 6 6 1 TPR repeat ANAPC3 PF12895.7 KOO29012.1 - 0.00068 19.8 0.7 0.82 9.9 0.0 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KOO29012.1 - 0.0009 19.7 4.4 0.43 11.1 0.0 3.1 3 1 1 4 4 4 3 Tetratricopeptide repeat DUF5113 PF17140.4 KOO29012.1 - 0.0077 16.0 1.2 0.0094 15.8 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5113) TPR_15 PF13429.6 KOO29012.1 - 0.011 14.9 6.7 0.25 10.5 0.2 2.7 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO29012.1 - 0.044 14.4 14.9 1.5 9.5 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO29012.1 - 0.048 13.7 5.1 2.2 8.5 0.1 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO29012.1 - 0.088 13.5 3.5 22 5.9 0.4 3.8 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO29012.1 - 0.18 11.7 8.6 5.6 7.0 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Tubulin PF00091.25 KOO29013.1 - 4.5e-09 36.8 0.1 4.7e-09 36.7 0.1 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 KOO29013.1 - 0.051 13.9 0.0 0.051 13.9 0.0 1.1 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain Aa_trans PF01490.18 KOO29014.1 - 7.1e-40 137.0 18.1 9.1e-33 113.6 9.2 2.6 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein NTPase_I-T PF01931.18 KOO29016.1 - 4.8e-31 107.8 0.0 1.5e-30 106.1 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function DUF84 DUF3429 PF11911.8 KOO29016.1 - 0.48 10.7 18.1 0.23 11.8 11.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3429) UPF0261 PF06792.11 KOO29016.1 - 1.5 7.7 6.4 0.11 11.4 1.5 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0261) Ribosomal_L32e PF01655.18 KOO29017.1 - 7.2e-44 148.6 1.1 8.6e-44 148.4 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Exo_endo_phos PF03372.23 KOO29019.1 - 0.00082 19.0 0.8 0.0016 18.0 0.2 1.6 1 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family HA PF03457.14 KOO29020.1 - 2.5e-31 107.8 2.4 2.6e-15 56.5 0.0 3.8 4 0 0 4 4 4 3 Helicase associated domain Peptidase_C14 PF00656.22 KOO29020.1 - 8.8e-11 42.2 0.0 1.3e-10 41.7 0.0 1.2 1 0 0 1 1 1 1 Caspase domain RuvA_C PF07499.13 KOO29020.1 - 0.029 14.8 0.5 0.9 10.0 0.1 2.9 2 0 0 2 2 2 0 RuvA, C-terminal domain RP-C PF03428.13 KOO29020.1 - 0.22 11.1 2.0 1.3 8.6 0.7 2.4 2 0 0 2 2 2 0 Replication protein C N-terminal domain PWI PF01480.17 KOO29021.1 - 8.2e-12 45.3 0.0 1.1e-11 44.9 0.0 1.1 1 0 0 1 1 1 1 PWI domain PIN_8 PF18476.1 KOO29022.1 - 0.0068 16.3 2.0 0.0076 16.1 2.0 1.2 1 0 0 1 1 1 1 PIN like domain DUF4407 PF14362.6 KOO29022.1 - 0.57 9.5 10.4 0.67 9.3 10.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Silic_transp PF03842.13 KOO29022.1 - 1.2 7.3 3.4 1.6 6.9 3.4 1.1 1 0 0 1 1 1 0 Silicon transporter DUF4604 PF15377.6 KOO29022.1 - 3.4 8.1 18.7 5.8 7.3 18.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4604) EF-hand_1 PF00036.32 KOO29023.1 - 9.6e-27 90.5 4.3 4.8e-06 25.7 0.3 6.1 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.6 KOO29023.1 - 2.7e-22 79.0 1.6 3.2e-09 37.1 0.0 3.8 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO29023.1 - 3e-19 68.6 13.4 4.3e-05 23.3 0.0 5.1 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO29023.1 - 2.6e-18 64.3 6.1 0.00055 19.7 0.1 6.4 6 1 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 KOO29023.1 - 2e-17 61.8 7.9 0.00011 21.5 0.1 5.5 5 0 0 5 5 5 4 EF hand EF-hand_10 PF14788.6 KOO29023.1 - 0.00062 19.6 0.5 0.84 9.6 0.0 2.8 2 0 0 2 2 2 2 EF hand RIIa PF02197.17 KOO29023.1 - 0.00073 19.2 0.0 0.0017 18.0 0.0 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EF-hand_4 PF12763.7 KOO29023.1 - 0.0077 16.2 5.2 2.5 8.1 0.1 4.3 3 2 2 5 5 5 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO29023.1 - 0.062 13.6 0.1 44 4.4 0.0 3.4 2 2 2 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region MatE PF01554.18 KOO29024.1 - 3.2e-19 69.1 19.1 1.4e-12 47.6 3.9 3.1 2 1 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 KOO29024.1 - 8.3e-08 32.4 3.8 8.3e-08 32.4 3.8 3.8 3 1 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain AgrD PF05931.11 KOO29024.1 - 0.17 12.0 0.3 0.8 9.8 0.0 2.2 2 0 0 2 2 2 0 Staphylococcal AgrD protein AAA PF00004.29 KOO29026.1 - 1.1e-91 304.1 0.0 4.5e-47 159.8 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO29026.1 - 8.2e-25 86.4 4.5 9.8e-13 47.7 0.8 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 KOO29026.1 - 1.3e-13 51.0 0.0 8.1e-06 25.7 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO29026.1 - 3.5e-12 47.1 2.6 0.00035 21.0 0.0 4.0 2 2 1 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 KOO29026.1 - 9.4e-12 45.3 0.1 8.7e-05 22.7 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_2 PF07724.14 KOO29026.1 - 8.2e-11 42.3 0.0 0.00061 19.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOO29026.1 - 7.1e-10 39.3 1.0 0.0091 16.3 0.0 4.0 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.14 KOO29026.1 - 9.2e-10 38.7 0.2 0.0019 18.2 0.0 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 KOO29026.1 - 4.1e-09 36.1 0.1 0.00046 19.5 0.0 2.4 2 1 0 2 2 2 2 TIP49 P-loop domain AAA_25 PF13481.6 KOO29026.1 - 2.3e-08 33.8 4.1 0.05 13.2 0.1 4.4 3 1 1 4 4 4 2 AAA domain RNA_helicase PF00910.22 KOO29026.1 - 2.7e-08 34.1 0.0 0.012 16.0 0.0 2.4 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 KOO29026.1 - 6.5e-08 32.7 0.6 0.01 15.8 0.0 3.3 2 1 1 3 3 3 2 NACHT domain IstB_IS21 PF01695.17 KOO29026.1 - 9.3e-08 32.0 0.1 0.0052 16.5 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 KOO29026.1 - 1.3e-07 31.7 0.0 0.015 15.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 KOO29026.1 - 2.1e-07 30.8 0.0 0.0022 17.9 0.0 2.5 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KOO29026.1 - 1.3e-06 27.9 0.4 0.041 13.2 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TsaE PF02367.17 KOO29026.1 - 1.8e-06 28.0 0.0 0.015 15.3 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 KOO29026.1 - 2.7e-06 27.4 0.0 0.045 13.7 0.0 2.3 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_28 PF13521.6 KOO29026.1 - 5.9e-06 26.6 0.1 0.12 12.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain ABC_tran PF00005.27 KOO29026.1 - 1.1e-05 25.9 0.0 0.08 13.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_18 PF13238.6 KOO29026.1 - 1.2e-05 25.9 0.0 0.17 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 KOO29026.1 - 4.6e-05 22.9 0.1 2.5 7.4 0.0 3.2 3 0 0 3 3 3 1 KaiC NB-ARC PF00931.22 KOO29026.1 - 5.5e-05 22.5 0.0 0.076 12.2 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Nucleolin_bd PF16725.5 KOO29026.1 - 7.8e-05 22.3 0.0 0.00016 21.3 0.0 1.4 1 0 0 1 1 1 1 Nucleolin binding domain Hydin_ADK PF17213.3 KOO29026.1 - 0.0001 22.7 0.4 0.12 12.6 0.0 2.5 2 0 0 2 2 2 2 Hydin Adenylate kinase-like domain Viral_helicase1 PF01443.18 KOO29026.1 - 0.00022 21.1 0.0 0.1 12.3 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 KOO29026.1 - 0.00037 20.0 0.0 1.5 8.2 0.0 3.1 3 0 0 3 3 3 2 PhoH-like protein AAA_17 PF13207.6 KOO29026.1 - 0.00039 20.8 0.0 0.82 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 KOO29026.1 - 0.00041 20.2 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 KOO29026.1 - 0.0011 18.7 0.1 0.25 11.0 0.0 3.2 3 1 0 3 3 3 1 Sigma-54 interaction domain Cytidylate_kin2 PF13189.6 KOO29026.1 - 0.0014 18.8 0.0 0.29 11.3 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase-like family Zeta_toxin PF06414.12 KOO29026.1 - 0.0017 17.6 0.0 0.86 8.8 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin ATPase_2 PF01637.18 KOO29026.1 - 0.0057 16.6 0.0 2.3 8.1 0.0 2.9 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea DUF2075 PF09848.9 KOO29026.1 - 0.0059 15.9 0.0 2.1 7.5 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 KOO29026.1 - 0.0077 15.8 0.0 2 7.9 0.0 2.5 2 1 0 2 2 2 1 P-loop containing dynein motor region SKI PF01202.22 KOO29026.1 - 0.0092 16.1 0.1 4.1 7.5 0.0 2.9 3 0 0 3 3 3 0 Shikimate kinase Parvo_NS1 PF01057.17 KOO29026.1 - 0.011 14.8 0.0 0.6 9.1 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Zot PF05707.12 KOO29026.1 - 0.012 15.3 0.0 0.33 10.6 0.0 3.0 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) Sigma54_activ_2 PF14532.6 KOO29026.1 - 0.025 14.7 0.0 0.78 9.9 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 KOO29026.1 - 0.029 14.7 0.7 12 6.2 0.1 2.8 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 KOO29026.1 - 0.047 13.4 0.0 6.8 6.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 KOO29026.1 - 0.051 12.5 0.0 1.1 8.1 0.0 2.4 2 0 0 2 2 2 0 AFG1-like ATPase NTPase_1 PF03266.15 KOO29026.1 - 0.069 13.1 0.2 11 5.9 0.0 3.0 3 1 1 4 4 3 0 NTPase DnaB_C PF03796.15 KOO29026.1 - 0.099 12.0 0.1 30 3.8 0.0 3.1 2 1 1 3 3 3 0 DnaB-like helicase C terminal domain Cytidylate_kin PF02224.18 KOO29026.1 - 0.13 12.0 0.4 11 5.7 0.1 2.5 2 0 0 2 2 2 0 Cytidylate kinase DAP3 PF10236.9 KOO29026.1 - 0.16 11.1 0.1 29 3.7 0.0 2.8 2 1 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 TPR_4 PF07721.14 KOO29027.1 - 1.1 10.0 4.1 0.75 10.6 0.4 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.25 KOO29028.1 - 1.3e-51 175.5 0.0 1.8e-51 175.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29028.1 - 7.7e-21 74.5 0.0 1.7e-20 73.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.20 KOO29028.1 - 0.024 14.2 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 KOO29028.1 - 0.031 14.2 0.0 0.067 13.1 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO29028.1 - 0.19 11.1 0.1 0.33 10.3 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Nop10p PF04135.12 KOO29030.1 - 1.2 9.3 10.6 0.067 13.2 1.4 2.6 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family Cast PF10174.9 KOO29032.1 - 0.015 13.6 1.5 0.017 13.4 1.5 1.0 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone YscO-like PF16789.5 KOO29032.1 - 0.036 14.1 2.4 0.24 11.4 0.1 2.1 2 0 0 2 2 2 0 YscO-like protein FdhE PF04216.12 KOO29032.1 - 0.066 13.1 1.1 0.083 12.8 1.1 1.1 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation DUF948 PF06103.11 KOO29032.1 - 0.07 13.4 0.4 0.33 11.2 0.1 2.0 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Sec2p PF06428.11 KOO29032.1 - 0.43 10.6 5.3 0.68 9.9 2.8 2.1 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p CBFD_NFYB_HMF PF00808.23 KOO29033.1 - 6.4e-08 32.8 0.0 8.9e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-X PF09415.10 KOO29033.1 - 0.091 13.1 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 CENP-S associating Centromere protein X PRR18 PF15671.5 KOO29033.1 - 0.16 11.8 4.8 0.21 11.4 4.8 1.3 1 0 0 1 1 1 0 Proline-rich protein family 18 DUF4508 PF14969.6 KOO29034.1 - 0.51 10.6 16.7 1.2 9.4 0.6 5.9 4 1 1 5 5 5 0 Domain of unknown function (DUF4508) Baculo_PEP_C PF04513.12 KOO29034.1 - 2.3 8.3 23.2 2.2 8.3 3.2 5.0 5 0 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Glyco_transf_29 PF00777.18 KOO29035.1 - 1.8e-28 99.7 0.0 1e-27 97.2 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) TMEM43 PF07787.12 KOO29036.1 - 0.092 12.1 0.5 0.16 11.4 0.5 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 EF-hand_7 PF13499.6 KOO29037.1 - 2.3e-32 111.3 12.2 2.2e-08 34.4 1.5 7.2 6 2 2 8 8 8 7 EF-hand domain pair EF-hand_1 PF00036.32 KOO29037.1 - 9.8e-32 106.1 18.0 0.0011 18.4 0.1 9.4 10 0 0 10 10 10 8 EF hand EF-hand_6 PF13405.6 KOO29037.1 - 2e-30 102.0 18.5 0.015 15.2 0.1 10.3 10 0 0 10 10 10 8 EF-hand domain EF-hand_5 PF13202.6 KOO29037.1 - 1.8e-27 93.6 23.4 0.00044 19.6 0.1 9.3 9 0 0 9 9 9 7 EF hand EF-hand_8 PF13833.6 KOO29037.1 - 7.9e-24 83.3 10.6 1e-05 25.2 1.4 8.6 7 2 2 9 9 9 7 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO29037.1 - 1.5e-05 25.2 0.3 4.9 7.5 0.0 4.8 5 1 0 5 5 5 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO29037.1 - 0.001 19.2 0.2 8 6.7 0.0 4.5 4 1 0 4 4 4 1 Dockerin type I domain EF-hand_4 PF12763.7 KOO29037.1 - 0.024 14.6 3.5 1.3 9.0 0.0 4.1 5 1 1 6 6 6 0 Cytoskeletal-regulatory complex EF hand BNIP3 PF06553.12 KOO29037.1 - 0.027 14.2 0.3 0.083 12.6 0.1 1.8 2 0 0 2 2 2 0 BNIP3 EF-hand_10 PF14788.6 KOO29037.1 - 0.042 13.7 0.6 2.1 8.3 0.0 3.6 4 0 0 4 4 4 0 EF hand Caleosin PF05042.13 KOO29037.1 - 0.064 13.2 0.1 10 6.0 0.0 3.0 3 0 0 3 3 3 0 Caleosin related protein Gb3_synth PF04572.12 KOO29038.1 - 1.5e-18 67.2 0.0 7.2e-09 35.9 0.0 2.2 2 0 0 2 2 2 2 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 KOO29038.1 - 2.4e-14 53.7 0.0 3.8e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 KOO29038.1 - 0.015 14.7 0.0 0.021 14.2 0.0 1.1 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein UL21a PF17636.2 KOO29038.1 - 0.064 13.3 0.8 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 Viral Unique Long protein 21a TcdA_TcdB PF12919.7 KOO29038.1 - 0.28 10.4 0.1 0.41 9.9 0.1 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain FGAR-AT_N PF18076.1 KOO29039.1 - 0.045 13.7 0.3 0.045 13.7 0.3 2.5 2 1 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase N-terminal DUF810 PF05664.11 KOO29040.1 - 0.0023 16.5 0.0 0.99 7.9 0.0 2.2 2 0 0 2 2 2 2 Plant family of unknown function (DUF810) EF-hand_1 PF00036.32 KOO29041.1 - 8.1e-17 59.5 3.8 9.2e-08 31.1 0.4 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO29041.1 - 8.2e-16 58.2 8.2 1.1e-10 41.9 2.7 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO29041.1 - 6.9e-15 53.6 3.1 1.1e-06 28.0 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KOO29041.1 - 6.4e-13 47.6 3.1 4.2e-06 26.0 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO29041.1 - 4.7e-11 42.4 3.9 8.1e-07 28.8 1.0 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_10 PF14788.6 KOO29041.1 - 0.06 13.2 1.6 0.28 11.1 0.1 2.4 2 0 0 2 2 2 0 EF hand PAS_3 PF08447.12 KOO29041.1 - 0.065 13.5 0.0 13 6.2 0.0 2.4 2 0 0 2 2 2 0 PAS fold MS_channel PF00924.18 KOO29043.1 - 9.4e-32 110.2 0.0 1.6e-31 109.4 0.0 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel Keratin_2_head PF16208.5 KOO29043.1 - 0.19 11.9 1.6 0.29 11.3 1.6 1.2 1 0 0 1 1 1 0 Keratin type II head Malate_synthase PF01274.22 KOO29044.1 - 1.7e-102 343.4 0.0 1.2e-59 201.9 0.0 2.0 1 1 1 2 2 2 2 Malate synthase Sulfotransfer_2 PF03567.14 KOO29045.1 - 0.045 13.7 0.1 0.11 12.3 0.0 1.6 2 0 0 2 2 2 0 Sulfotransferase family Arm PF00514.23 KOO29046.1 - 8.2e-30 101.9 10.8 1.7e-07 31.0 0.2 5.2 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat U-box PF04564.15 KOO29046.1 - 6e-13 48.8 0.0 1.3e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain Atx10homo_assoc PF09759.9 KOO29046.1 - 1.7e-06 27.9 0.0 0.019 15.0 0.0 3.3 4 0 0 4 4 4 2 Spinocerebellar ataxia type 10 protein domain zf-Nse PF11789.8 KOO29046.1 - 3.9e-05 23.4 0.0 8.7e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO29046.1 - 0.011 15.9 0.0 0.025 14.7 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein SPATA1_C PF15743.5 KOO29046.1 - 0.059 13.4 2.8 0.12 12.4 2.8 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus zf-RING_UBOX PF13445.6 KOO29046.1 - 0.09 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Csm1_N PF18504.1 KOO29046.1 - 0.63 10.4 4.4 4.1 7.8 0.8 2.9 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF1690 PF07956.11 KOO29046.1 - 4.6 7.7 15.2 1.7 9.1 5.7 2.9 3 0 0 3 3 3 0 Protein of Unknown function (DUF1690) Spc7 PF08317.11 KOO29046.1 - 9.7 5.0 7.9 21 3.9 7.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4200 PF13863.6 KOO29047.1 - 0.019 15.3 19.4 0.6 10.5 0.2 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) Spc7 PF08317.11 KOO29047.1 - 0.053 12.4 22.0 0.05 12.5 21.0 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Macoilin PF09726.9 KOO29047.1 - 0.16 10.5 16.2 0.23 10.0 16.2 1.2 1 0 0 1 1 1 0 Macoilin family DUF1664 PF07889.12 KOO29047.1 - 0.44 10.6 4.2 5.7 7.0 3.1 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) YtxH PF12732.7 KOO29047.1 - 0.67 10.5 7.6 1.1 9.8 1.8 3.1 2 1 0 2 2 2 0 YtxH-like protein FAM76 PF16046.5 KOO29047.1 - 0.74 9.1 10.0 2.5 7.4 10.0 1.7 1 1 1 2 2 2 0 FAM76 protein LMBR1 PF04791.16 KOO29047.1 - 0.88 8.4 4.6 1.1 8.1 4.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Lectin_N PF03954.14 KOO29047.1 - 1.2 8.9 7.4 35 4.1 0.7 3.3 2 1 0 3 3 3 0 Hepatic lectin, N-terminal domain ADIP PF11559.8 KOO29047.1 - 1.9 8.6 23.5 5 7.2 9.3 2.4 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 KOO29047.1 - 2.9 8.3 23.5 2.7 8.4 21.7 1.8 1 1 1 2 2 2 0 Fez1 Atg14 PF10186.9 KOO29047.1 - 4.5 6.3 22.0 0.83 8.7 12.5 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_DNA_bd PF12329.8 KOO29047.1 - 9.7 6.3 20.4 8.8 6.4 7.2 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Inositol_P PF00459.25 KOO29048.1 - 8.7e-09 35.3 0.2 1.3e-08 34.7 0.2 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family DUF1499 PF07386.11 KOO29049.1 - 1.7e-16 60.8 0.0 2.8e-16 60.1 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1499) MdcG PF10620.9 KOO29049.1 - 0.2 11.4 2.3 0.67 9.7 2.3 1.7 1 1 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG Methyltransf_21 PF05050.12 KOO29050.1 - 0.0005 20.1 0.0 0.00077 19.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain TSC22 PF01166.18 KOO29052.1 - 0.2 12.0 0.1 0.2 12.0 0.1 3.5 3 1 0 3 3 3 0 TSC-22/dip/bun family DUF3584 PF12128.8 KOO29052.1 - 2.9 5.3 34.2 4.6 4.6 34.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CPSase_L_D2 PF02786.17 KOO29053.1 - 9.2e-06 25.3 0.0 0.12 11.8 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CH PF00307.31 KOO29054.1 - 5e-29 100.7 0.1 6.6e-18 64.9 0.2 2.8 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KOO29054.1 - 5e-05 23.0 0.0 0.0039 17.0 0.0 2.7 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_6 PF13405.6 KOO29055.1 - 1.1e-12 46.8 0.1 0.001 18.8 0.0 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 KOO29055.1 - 4.9e-12 44.5 0.4 0.0039 16.6 0.0 4.5 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KOO29055.1 - 3.1e-11 43.5 0.0 0.00014 22.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO29055.1 - 4.7e-06 25.8 2.0 0.24 10.9 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO29055.1 - 0.00034 20.4 0.0 3.2 7.7 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO29055.1 - 0.0043 17.4 0.0 4 7.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain DNA_ligase_IV PF11411.8 KOO29055.1 - 0.034 14.3 0.3 15 5.8 0.0 2.6 3 0 0 3 3 3 0 DNA ligase IV PipA PF07108.11 KOO29055.1 - 0.038 13.5 0.1 7.9 5.9 0.0 2.2 2 0 0 2 2 2 0 PipA protein DUF2666 PF10869.8 KOO29055.1 - 0.14 12.4 0.0 26 5.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) VCBS PF13517.6 KOO29056.1 - 2e-146 476.7 168.4 2.1e-14 53.9 6.2 15.5 3 3 12 15 15 15 15 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO29056.1 - 1.2e-73 242.7 172.6 1.1e-05 25.4 0.9 17.7 17 0 0 17 17 17 17 FG-GAP repeat Dockerin_1 PF00404.18 KOO29056.1 - 1.8e-11 44.1 58.6 5 7.4 0.0 16.8 16 1 1 17 17 17 5 Dockerin type I domain TM_PBP2_N PF16296.5 KOO29056.1 - 3.6e-06 27.0 0.0 18 5.6 0.0 8.1 11 0 0 11 11 11 1 N-terminal of TM subunit in PBP-dependent ABC transporters TcdB_toxin_midN PF12256.8 KOO29056.1 - 0.00058 19.3 82.0 3.6 6.9 0.1 16.5 4 3 10 17 17 17 10 Insecticide toxin TcdB middle/N-terminal region BBS1 PF14779.6 KOO29056.1 - 0.0085 15.6 14.2 44 3.4 0.0 10.4 14 1 1 15 15 15 0 Ciliary BBSome complex subunit 1 DUF756 PF05506.12 KOO29056.1 - 0.023 15.6 0.0 1.8e+02 3.1 0.0 4.9 3 2 2 5 5 5 0 Domain of unknown function (DUF756) EF-hand_1 PF00036.32 KOO29056.1 - 2.4 7.9 77.3 48 3.8 0.1 16.8 17 0 0 17 17 17 0 EF hand Peptidase_S9 PF00326.21 KOO29057.1 - 1.7e-38 132.2 0.0 2.7e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 KOO29057.1 - 2e-08 33.5 0.0 0.00054 18.9 0.0 2.3 2 1 0 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain NO_synthase PF02898.15 KOO29058.1 - 2.9e-114 381.9 0.0 4.5e-114 381.3 0.0 1.3 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.20 KOO29058.1 - 6.7e-14 52.0 0.0 3e-13 49.9 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 KOO29058.1 - 1.7e-12 48.0 0.0 3.3e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.25 KOO29058.1 - 8.7e-10 39.0 0.0 3.3e-09 37.1 0.0 2.0 1 1 0 1 1 1 1 Flavodoxin SET_assoc PF11767.8 KOO29060.1 - 2.1e-06 27.3 3.5 40 3.9 0.0 7.9 8 0 0 8 8 8 4 Histone lysine methyltransferase SET associated MORN PF02493.20 KOO29062.1 - 6.4e-61 198.8 62.6 2.4e-07 30.3 0.5 11.1 11 0 0 11 11 11 10 MORN repeat Ribosomal_L21e PF01157.18 KOO29063.1 - 5.1e-39 132.2 2.9 7.4e-39 131.7 2.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L21e 2OG-FeII_Oxy_3 PF13640.6 KOO29064.1 - 3e-12 47.3 0.0 5.8e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO29064.1 - 2.1e-07 31.4 8.5 3.9e-07 30.5 8.5 1.5 1 0 0 1 1 1 1 ShK domain-like Exo_endo_phos PF03372.23 KOO29065.1 - 4.2e-05 23.2 0.0 0.15 11.5 0.0 2.1 1 1 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family Chloroa_b-bind PF00504.21 KOO29066.1 - 9.2e-37 127.1 0.3 1.3e-36 126.6 0.3 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein HMGL-like PF00682.19 KOO29067.1 - 3.1e-10 40.1 0.2 4e-10 39.7 0.2 1.1 1 0 0 1 1 1 1 HMGL-like SPDY PF03771.16 KOO29067.1 - 0.23 11.4 0.1 0.23 11.4 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF317) Pkinase PF00069.25 KOO29068.1 - 6.2e-54 183.1 0.0 1.2e-53 182.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29068.1 - 9.8e-30 103.7 0.0 1.7e-29 102.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase IPK PF03770.16 KOO29068.1 - 2.6e-13 50.3 0.0 4.8e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Kinase-like PF14531.6 KOO29068.1 - 0.00013 21.4 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO29068.1 - 0.00081 18.3 0.0 0.0014 17.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 KOO29068.1 - 0.0027 17.4 0.0 1.6 8.3 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KOO29068.1 - 0.028 14.3 0.1 0.09 12.7 0.1 1.9 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA_5 PF07728.14 KOO29069.1 - 4.8e-06 26.6 0.0 0.0026 17.8 0.0 3.0 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA PF00004.29 KOO29069.1 - 1.1e-05 25.8 0.0 0.24 11.8 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO29069.1 - 0.00031 21.2 0.1 0.033 14.6 0.0 4.5 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 KOO29069.1 - 0.00034 20.9 0.0 0.053 13.8 0.0 3.1 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 KOO29069.1 - 0.00093 19.3 0.0 7.3 6.7 0.0 3.8 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_7 PF12775.7 KOO29069.1 - 0.0036 16.8 0.0 2.9 7.4 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_30 PF13604.6 KOO29069.1 - 0.032 14.0 0.1 5.7 6.6 0.0 3.4 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 KOO29069.1 - 0.13 12.3 0.4 1.3 9.0 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Histone_HNS PF00816.21 KOO29070.1 - 2.4 9.1 8.5 9 7.2 2.1 2.6 2 0 0 2 2 2 0 H-NS histone family PIF1 PF05970.14 KOO29071.1 - 1.8e-27 96.5 0.0 3.3e-27 95.6 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 KOO29071.1 - 5.1e-22 79.0 0.4 1.9e-21 77.2 0.4 1.9 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 KOO29071.1 - 1.1e-17 64.5 0.0 2.8e-17 63.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO29071.1 - 0.00017 21.9 0.0 0.00049 20.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KOO29071.1 - 0.012 15.4 0.1 0.047 13.5 0.1 2.0 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 KOO29071.1 - 0.013 15.8 3.0 0.015 15.7 0.1 2.6 3 0 0 3 3 3 0 AAA ATPase domain AAA_5 PF07728.14 KOO29071.1 - 0.024 14.6 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CbiA PF01656.23 KOO29071.1 - 0.031 14.3 0.0 1.7 8.7 0.1 2.4 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Viral_helicase1 PF01443.18 KOO29071.1 - 0.056 13.2 0.0 3.8 7.2 0.0 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KOO29071.1 - 0.068 13.4 0.0 0.21 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Imm31 PF15591.6 KOO29071.1 - 0.13 12.1 0.0 5 7.0 0.0 2.6 2 0 0 2 2 2 0 Immunity protein 31 Inovirus_Gp2 PF11726.8 KOO29071.1 - 0.15 12.0 0.1 0.34 10.9 0.1 1.5 1 0 0 1 1 1 0 Inovirus Gp2 MFMR_assoc PF16596.5 KOO29071.1 - 0.77 10.2 8.2 16 6.0 0.0 2.6 2 0 0 2 2 2 0 Disordered region downstream of MFMR Cwf_Cwc_15 PF04889.12 KOO29071.1 - 1.6 8.4 13.9 2.9 7.5 5.8 2.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein cNMP_binding PF00027.29 KOO29072.1 - 1.5e-31 108.3 0.1 3.6e-14 52.6 0.0 3.4 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain PAN_1 PF00024.26 KOO29073.1 - 0.028 14.4 1.5 0.061 13.3 1.5 1.6 1 0 0 1 1 1 0 PAN domain PAN_4 PF14295.6 KOO29073.1 - 1.5 8.8 20.4 21 5.1 20.4 2.7 1 1 0 1 1 1 0 PAN domain HSF_DNA-bind PF00447.17 KOO29074.1 - 1.3e-22 80.2 0.0 3.3e-20 72.5 0.0 2.3 2 0 0 2 2 2 2 HSF-type DNA-binding PAS_9 PF13426.7 KOO29074.1 - 8.5e-17 61.3 0.0 1.3e-11 44.7 0.0 2.3 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.7 KOO29074.1 - 1.5e-12 47.2 0.0 1.3e-05 25.1 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 KOO29074.1 - 9e-09 35.3 0.0 0.0013 18.7 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 KOO29074.1 - 1.8e-07 31.4 0.0 0.00093 19.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.12 KOO29074.1 - 0.00076 19.7 0.0 1.7 9.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold Ets PF00178.22 KOO29074.1 - 0.062 13.8 0.0 0.9 10.0 0.0 2.4 2 1 1 3 3 3 0 Ets-domain Lipase_GDSL_2 PF13472.6 KOO29075.1 - 0.13 12.7 0.0 0.32 11.4 0.0 1.7 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family DUF4820 PF16091.5 KOO29076.1 - 0.015 14.7 0.1 0.021 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) GILT PF03227.16 KOO29078.1 - 4.8e-06 26.8 0.1 3.6e-05 24.0 0.1 2.4 1 1 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) DUF5082 PF16888.5 KOO29078.1 - 0.45 10.8 4.1 1.8 8.8 0.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) TPR_2 PF07719.17 KOO29079.1 - 3.8e-09 36.0 3.1 0.0044 17.0 0.3 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO29079.1 - 8.7e-06 25.3 1.2 0.068 13.0 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO29079.1 - 4.1e-05 23.4 0.3 2.1 8.7 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO29079.1 - 0.0005 20.3 3.2 0.0005 20.3 3.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO29079.1 - 0.0011 19.6 12.6 0.021 15.5 4.6 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat SAM_2 PF07647.17 KOO29079.1 - 0.0017 18.4 0.0 0.0033 17.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_11 PF13414.6 KOO29079.1 - 0.0023 17.5 0.3 3.4 7.4 0.4 2.8 2 1 0 2 2 2 2 TPR repeat SAM_1 PF00536.30 KOO29079.1 - 0.0036 17.7 0.0 0.012 16.0 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) STAS_2 PF13466.6 KOO29079.1 - 0.06 13.7 0.4 3.2 8.2 0.0 3.4 3 1 0 3 3 3 0 STAS domain TPR_14 PF13428.6 KOO29079.1 - 0.52 11.3 8.7 2.8 9.0 0.6 3.3 1 1 2 3 3 3 0 Tetratricopeptide repeat Ank_2 PF12796.7 KOO29080.1 - 2.9e-25 88.7 2.1 1e-10 42.0 0.4 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO29080.1 - 7.1e-21 74.3 0.7 2.6e-06 27.9 0.0 4.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO29080.1 - 1.4e-15 56.9 4.4 0.0006 20.1 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KOO29080.1 - 3.4e-13 49.5 3.3 1.4e-06 28.5 0.5 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO29080.1 - 8.5e-13 47.2 0.1 0.05 14.2 0.0 4.7 5 0 0 5 5 5 4 Ankyrin repeat UBA PF00627.31 KOO29080.1 - 0.00045 20.1 0.5 0.018 14.9 0.0 2.8 2 0 0 2 2 2 1 UBA/TS-N domain PTS_IIA PF02255.16 KOO29080.1 - 0.0035 17.4 0.4 0.022 14.8 0.1 2.2 2 0 0 2 2 2 1 PTS system, Lactose/Cellobiose specific IIA subunit DUF4226 PF10774.9 KOO29080.1 - 0.024 14.9 0.4 0.024 14.9 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4226) CheD PF03975.13 KOO29080.1 - 0.08 13.0 0.1 0.38 10.9 0.1 2.1 1 1 1 2 2 2 0 CheD chemotactic sensory transduction Sulfate_transp PF00916.20 KOO29081.1 - 4.7e-76 256.0 31.0 6e-76 255.7 31.0 1.0 1 0 0 1 1 1 1 Sulfate permease family ADH_N PF08240.12 KOO29082.1 - 6.5e-21 74.3 1.9 1.8e-20 72.8 1.9 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOO29082.1 - 3e-08 33.7 2.8 1.6e-07 31.3 1.1 2.7 2 1 0 2 2 2 1 Zinc-binding dehydrogenase PALP PF00291.25 KOO29082.1 - 0.00012 21.6 0.4 0.00021 20.8 0.4 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme AlaDh_PNT_C PF01262.21 KOO29082.1 - 0.0036 16.6 1.1 0.0058 16.0 0.3 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 KOO29082.1 - 0.052 12.8 0.1 0.057 12.7 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 KOO29082.1 - 0.16 11.2 1.2 0.34 10.1 1.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RdRP PF05183.12 KOO29083.1 - 1.3e-31 109.9 0.0 4.1e-27 95.1 0.0 2.2 1 1 1 2 2 2 2 RNA dependent RNA polymerase Peptidase_C1 PF00112.23 KOO29084.1 - 1.2e-40 139.9 4.3 1.7e-40 139.5 4.3 1.2 1 0 0 1 1 1 1 Papain family cysteine protease DUF676 PF05057.14 KOO29085.1 - 2.8e-37 128.4 0.0 3.9e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 KOO29085.1 - 1.5e-06 28.2 0.0 2.2e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 KOO29085.1 - 0.00074 19.3 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 KOO29085.1 - 0.003 18.2 0.1 0.003 18.2 0.1 2.8 2 1 0 2 2 2 1 Alpha/beta hydrolase family cNMP_binding PF00027.29 KOO29086.1 - 1.1e-09 38.2 0.2 5e-07 29.7 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain EF-hand_6 PF13405.6 KOO29086.1 - 4.1e-09 35.6 0.0 2.5e-05 23.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO29086.1 - 7.2e-09 34.6 0.0 0.0019 17.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO29086.1 - 1.7e-06 28.3 0.0 4.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO29086.1 - 6.2e-05 22.3 0.0 0.034 13.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO29086.1 - 0.00021 21.1 0.0 0.0011 18.8 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair ATG16 PF08614.11 KOO29086.1 - 0.097 12.9 34.0 0.22 11.8 3.0 2.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CALCOCO1 PF07888.11 KOO29086.1 - 1.1 8.0 34.5 0.5 9.2 22.5 2.2 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like YabA PF06156.13 KOO29086.1 - 1.7 9.3 18.1 1.4 9.6 0.7 3.8 3 0 0 3 3 3 0 Initiation control protein YabA WD40 PF00400.32 KOO29088.1 - 9.7e-14 51.6 10.7 2.2e-05 25.1 0.7 4.1 3 0 0 3 3 3 3 WD domain, G-beta repeat PQQ_3 PF13570.6 KOO29088.1 - 0.019 15.4 1.9 1.2 9.7 0.0 4.1 5 0 0 5 5 5 0 PQQ-like domain Ank_2 PF12796.7 KOO29089.1 - 3.8e-64 213.3 36.7 1.7e-11 44.6 0.8 7.7 1 1 9 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO29089.1 - 7.6e-48 160.3 12.9 5.2e-07 30.1 0.1 9.4 4 3 7 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO29089.1 - 1.7e-45 147.7 15.2 0.0015 18.8 0.0 14.4 14 0 0 14 14 14 12 Ankyrin repeat Ank PF00023.30 KOO29089.1 - 1.8e-42 142.0 34.5 0.00029 21.2 0.1 14.2 14 0 0 14 14 14 11 Ankyrin repeat Ank_5 PF13857.6 KOO29089.1 - 2.7e-35 119.9 20.1 1.8e-05 24.9 0.1 10.2 4 3 6 10 10 10 10 Ankyrin repeats (many copies) PEPCK_ATP PF01293.20 KOO29092.1 - 4.9e-201 668.4 0.0 5.8e-201 668.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 KOO29092.1 - 0.055 13.6 0.0 0.15 12.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO29092.1 - 0.14 12.5 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain WD40 PF00400.32 KOO29093.1 - 7e-22 77.3 0.8 0.00036 21.3 0.0 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO29093.1 - 7.3e-10 39.0 0.0 0.039 14.3 0.0 4.9 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO29093.1 - 0.14 12.2 3.5 1.4 8.9 0.1 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat VID27 PF08553.10 KOO29093.1 - 0.22 10.5 0.0 3.6 6.6 0.0 2.2 2 1 0 2 2 2 0 VID27 C-terminal WD40-like domain Kinesin PF00225.23 KOO29094.1 - 1.6e-93 313.3 0.0 2.5e-93 312.7 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO29094.1 - 2.6e-20 72.9 0.0 5.5e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding PA28_beta PF02252.18 KOO29094.1 - 0.014 15.0 0.5 0.026 14.2 0.5 1.4 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit SRC-1 PF08832.10 KOO29094.1 - 0.13 13.3 0.3 0.66 11.1 0.3 2.2 1 0 0 1 1 1 0 Steroid receptor coactivator AAA_23 PF13476.6 KOO29094.1 - 2.8 8.4 5.4 3.3 8.1 1.9 2.4 2 0 0 2 2 2 0 AAA domain DivIC PF04977.15 KOO29094.1 - 3.3 7.5 7.4 1.3 8.8 0.2 3.5 2 1 2 4 4 4 0 Septum formation initiator Dynamin_N PF00350.23 KOO29095.1 - 1e-19 71.2 0.0 2.1e-19 70.2 0.0 1.5 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 KOO29095.1 - 3.2e-06 27.2 0.0 1.5e-05 25.0 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 KOO29095.1 - 0.017 14.5 0.0 0.82 9.0 0.0 2.2 2 0 0 2 2 2 0 AIG1 family FeoB_N PF02421.18 KOO29095.1 - 0.019 14.5 0.0 1 8.9 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF892 PF05974.12 KOO29095.1 - 0.036 14.1 0.2 0.074 13.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF892) Ras PF00071.22 KOO29096.1 - 2.5e-40 137.7 0.0 3.3e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO29096.1 - 4e-25 88.4 0.0 6.7e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO29096.1 - 4.5e-09 36.0 0.0 6.1e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOO29096.1 - 3.4e-05 23.3 0.0 4.6e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 KOO29096.1 - 0.058 13.1 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 KOO29096.1 - 0.071 12.3 0.2 1.3 8.1 0.0 2.4 1 1 1 2 2 2 0 G-protein alpha subunit SRPRB PF09439.10 KOO29096.1 - 0.15 11.5 0.0 0.2 11.1 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Orai-1 PF07856.12 KOO29097.1 - 0.14 11.8 5.8 0.61 9.8 5.8 1.8 1 1 0 1 1 1 0 Mediator of CRAC channel activity Kinesin PF00225.23 KOO29098.1 - 9.3e-76 254.9 0.0 1.9e-75 253.8 0.0 1.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOO29098.1 - 2.8e-14 53.3 0.4 2.7e-13 50.1 0.0 2.5 3 0 0 3 3 3 1 Microtubule binding YabA PF06156.13 KOO29098.1 - 1.6 9.4 10.8 1.1 10.0 1.7 2.6 2 0 0 2 2 2 0 Initiation control protein YabA DUF4559 PF15112.6 KOO29098.1 - 1.9 8.1 9.5 2.9 7.5 9.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Pkinase PF00069.25 KOO29099.1 - 4.2e-71 239.4 0.0 4.8e-71 239.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29099.1 - 2.1e-32 112.4 0.0 2.6e-32 112.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO29099.1 - 0.014 14.4 0.0 0.029 13.3 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KOO29099.1 - 0.052 13.5 0.1 0.13 12.2 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO29099.1 - 0.081 12.3 0.1 0.29 10.5 0.1 1.8 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO29099.1 - 0.099 11.9 0.1 1.3 8.3 0.0 2.3 2 1 0 2 2 2 0 Kinase-like Lactamase_B_2 PF12706.7 KOO29100.1 - 7.6e-09 35.4 0.4 7.5e-07 28.9 0.4 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KOO29100.1 - 1.8e-05 24.8 0.2 0.00011 22.2 0.0 2.2 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Ion_trans PF00520.31 KOO29102.1 - 7.6e-31 107.2 8.7 1e-30 106.8 8.7 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO29102.1 - 1.7e-05 23.7 7.4 0.0031 16.2 0.8 3.1 3 0 0 3 3 3 2 Polycystin cation channel DUF5090 PF17009.5 KOO29102.1 - 7.8 6.4 11.9 0.64 9.9 4.6 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5090) PG_binding_1 PF01471.18 KOO29103.1 - 4.9e-06 26.7 0.1 1e-05 25.6 0.1 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain ZZ PF00569.17 KOO29103.1 - 0.00035 20.3 0.2 0.00057 19.6 0.2 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF4632 PF15451.6 KOO29103.1 - 0.037 14.1 0.4 0.14 12.3 0.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4632) PG_binding_3 PF09374.10 KOO29103.1 - 0.038 14.3 0.0 0.074 13.3 0.0 1.4 1 0 0 1 1 1 0 Predicted Peptidoglycan domain LRR_6 PF13516.6 KOO29104.1 - 5.5e-22 75.9 14.2 7.1e-05 22.6 0.1 7.1 8 0 0 8 8 8 6 Leucine Rich repeat Ank_2 PF12796.7 KOO29104.1 - 4.5e-17 62.4 0.3 4.8e-07 30.3 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO29104.1 - 1.5e-14 53.8 3.4 4.6e-10 39.5 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO29104.1 - 3e-13 50.0 0.8 8.4e-07 29.4 0.1 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO29104.1 - 1.3e-12 46.7 1.3 0.00071 19.8 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOO29104.1 - 4.2e-12 45.9 0.6 2.9e-05 24.3 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat 3HCDH_RFF PF18321.1 KOO29104.1 - 0.039 14.4 10.6 0.083 13.3 0.1 4.4 5 1 1 6 6 6 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Arm-DNA-bind_1 PF09003.10 KOO29104.1 - 5.1 7.3 14.1 9.2 6.5 0.0 5.1 4 1 1 5 5 5 0 Bacteriophage lambda integrase, Arm DNA-binding domain Fringe PF02434.16 KOO29106.1 - 3.3e-25 89.0 0.0 7.2e-25 87.9 0.0 1.5 1 1 0 1 1 1 1 Fringe-like DUF604 PF04646.12 KOO29106.1 - 0.0019 17.7 0.0 0.0032 16.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Milton PF12448.8 KOO29109.1 - 0.2 11.7 0.5 0.24 11.5 0.5 1.1 1 0 0 1 1 1 0 Kinesin associated protein Renin_r PF07850.14 KOO29110.1 - 9.1e-05 23.0 2.2 9.8e-05 22.9 1.6 1.4 1 1 1 2 2 2 1 Renin receptor-like protein SAP PF02037.27 KOO29111.1 - 5.3e-15 54.8 1.5 2.1e-07 30.6 0.1 2.6 2 0 0 2 2 2 2 SAP domain SURF2 PF05477.11 KOO29111.1 - 7.4e-06 25.8 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) HeH PF12949.7 KOO29111.1 - 0.095 12.4 0.6 3 7.7 0.1 2.4 2 0 0 2 2 2 0 HeH/LEM domain Mito_carr PF00153.27 KOO29112.1 - 3.6e-44 148.6 0.2 3.9e-13 49.1 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EutK_C PF16365.5 KOO29112.1 - 0.02 14.9 0.1 0.058 13.4 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilization protein EutK C-terminus EF-hand_1 PF00036.32 KOO29112.1 - 0.24 11.0 0.4 1.2 8.8 0.0 2.4 3 0 0 3 3 3 0 EF hand zf-RING_2 PF13639.6 KOO29113.1 - 5.4e-08 33.0 9.2 1.4e-07 31.7 9.2 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KOO29113.1 - 2.7e-07 30.4 7.7 6.8e-07 29.1 7.7 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO29113.1 - 3e-07 30.3 5.8 3.1e-07 30.3 2.8 2.5 1 1 1 2 2 2 1 RING-type zinc-finger Glycos_transf_1 PF00534.20 KOO29113.1 - 2.1e-05 24.1 0.0 0.065 12.8 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 zf-C3HC4_3 PF13920.6 KOO29113.1 - 2.2e-05 24.2 8.0 6.2e-05 22.8 8.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO29113.1 - 7.6e-05 22.5 9.2 0.00018 21.3 9.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO29113.1 - 9.9e-05 22.1 8.6 0.00024 20.9 8.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO29113.1 - 0.0012 18.6 11.2 0.014 15.3 11.6 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KOO29113.1 - 0.0041 17.2 12.1 0.0091 16.1 9.7 2.9 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING Asparaginase_C PF17763.1 KOO29113.1 - 0.013 15.7 0.0 0.038 14.2 0.0 1.8 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain Glyco_trans_1_4 PF13692.6 KOO29113.1 - 0.015 15.7 0.1 2.7 8.4 0.0 3.1 2 1 1 3 3 3 0 Glycosyl transferases group 1 CDC24_OB3 PF17244.2 KOO29113.1 - 0.07 12.8 0.5 0.12 12.1 0.5 1.3 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 zf-RING_4 PF14570.6 KOO29113.1 - 0.076 12.8 7.3 0.24 11.2 7.3 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Syndecan PF01034.20 KOO29113.1 - 0.14 12.1 0.5 0.35 10.8 0.5 1.6 1 0 0 1 1 1 0 Syndecan domain Siva PF05458.12 KOO29113.1 - 0.2 11.3 7.3 0.46 10.1 7.3 1.6 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-RING_11 PF17123.5 KOO29113.1 - 0.29 10.9 7.9 0.029 14.1 2.7 2.1 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_6 PF14835.6 KOO29113.1 - 0.47 10.3 7.6 0.14 12.0 3.5 2.3 2 0 0 2 2 1 0 zf-RING of BARD1-type protein DUF1323 PF07037.11 KOO29114.1 - 0.0011 19.4 8.1 2.3 8.6 0.2 4.0 1 1 3 4 4 4 3 Putative transcription regulator (DUF1323) FinO_N PF12602.8 KOO29114.1 - 0.78 10.1 21.5 10 6.5 0.2 4.8 4 1 0 4 4 4 0 Fertility inhibition protein N terminal CSTF_C PF14304.6 KOO29114.1 - 5.5 6.7 12.1 40 3.9 0.2 4.0 4 0 0 4 4 4 0 Transcription termination and cleavage factor C-terminal HTH_23 PF13384.6 KOO29115.1 - 0.00049 19.8 0.2 0.0017 18.1 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 KOO29115.1 - 0.0014 18.7 0.0 0.0069 16.5 0.0 2.3 1 0 0 1 1 1 1 Helix-turn-helix domain DUF3606 PF12244.8 KOO29115.1 - 0.0052 16.7 0.3 0.014 15.3 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3606) HTH_Tnp_ISL3 PF13542.6 KOO29115.1 - 0.0095 15.3 0.0 0.026 13.9 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_7 PF02796.15 KOO29115.1 - 0.073 13.2 0.0 0.78 9.9 0.0 2.3 1 1 1 2 2 2 0 Helix-turn-helix domain of resolvase Ion_trans PF00520.31 KOO29116.1 - 2.6e-161 534.5 58.4 7.6e-51 172.7 2.3 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO29116.1 - 1.9e-10 40.0 52.8 0.00041 19.2 7.6 7.4 5 2 2 7 7 7 7 Polycystin cation channel GPHH PF16905.5 KOO29116.1 - 5.3e-09 35.7 0.0 1.2e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Glutaredoxin PF00462.24 KOO29117.1 - 2.4e-16 59.7 0.0 4.3e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 KOO29117.1 - 0.0011 19.3 0.0 0.0025 18.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF2946 PF11162.8 KOO29117.1 - 0.042 14.5 1.7 0.079 13.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) GST_N_2 PF13409.6 KOO29117.1 - 0.18 12.1 0.0 0.46 10.8 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Phosphoesterase PF04185.14 KOO29118.1 - 3.6e-55 187.6 0.1 5.5e-55 187.0 0.1 1.1 1 0 0 1 1 1 1 Phosphoesterase family cobW PF02492.19 KOO29119.1 - 2.9e-50 170.3 0.3 4.5e-50 169.7 0.3 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KOO29119.1 - 4.6e-22 77.8 0.0 8.9e-22 76.8 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 KOO29119.1 - 0.00081 19.3 0.0 0.22 11.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase TsaE PF02367.17 KOO29119.1 - 0.015 15.3 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KOO29119.1 - 0.016 15.5 0.0 0.037 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO29119.1 - 0.024 15.0 0.1 0.079 13.3 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain MobB PF03205.14 KOO29119.1 - 0.033 14.1 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.6 KOO29119.1 - 0.082 13.1 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 KOO29119.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 KOO29119.1 - 0.19 12.2 0.0 0.35 11.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter PDZ PF00595.24 KOO29121.1 - 4.1e-05 23.8 0.0 7.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO29121.1 - 0.0019 18.0 0.1 0.0036 17.1 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO29121.1 - 0.0065 16.8 0.2 0.011 16.0 0.2 1.4 1 0 0 1 1 1 1 PDZ domain EF-hand_1 PF00036.32 KOO29124.1 - 0.046 13.3 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO29124.1 - 0.063 13.7 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 KOO29124.1 - 0.16 11.6 0.0 0.36 10.4 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_4 PF12763.7 KOO29124.1 - 0.2 11.6 0.0 0.44 10.5 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand CHASE8 PF17152.4 KOO29124.1 - 0.62 10.3 4.2 17 5.7 1.0 2.8 2 1 0 2 2 2 0 Periplasmic sensor domain EF-hand_1 PF00036.32 KOO29125.1 - 1.5e-20 71.2 1.5 5e-05 22.5 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO29125.1 - 1.3e-18 67.1 0.1 9.1e-08 32.4 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO29125.1 - 1.7e-16 58.6 0.9 0.00095 18.9 0.0 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 KOO29125.1 - 9.2e-13 47.1 0.7 0.0017 17.7 0.0 4.7 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO29125.1 - 5.5e-11 42.1 3.6 0.024 14.5 0.0 4.5 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO29125.1 - 0.0011 19.3 0.1 1.1 9.6 0.0 2.8 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 KOO29125.1 - 0.0041 15.7 0.1 0.087 11.3 0.0 2.2 1 1 0 2 2 2 1 Family of unknown function (DUF5580) EF-hand_4 PF12763.7 KOO29125.1 - 0.0046 16.9 0.0 2.9 7.9 0.0 2.6 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Decorin_bind PF02352.15 KOO29126.1 - 0.03 14.6 0.0 0.081 13.2 0.0 1.7 1 0 0 1 1 1 0 Decorin binding protein Cupin_8 PF13621.6 KOO29127.1 - 6.5e-29 101.4 0.1 3.1e-28 99.2 0.1 1.9 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 KOO29127.1 - 0.0015 18.9 0.0 0.0032 17.9 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 KOO29127.1 - 0.002 17.6 0.1 0.029 13.8 0.1 2.2 1 1 0 1 1 1 1 Cupin superfamily protein DUF664 PF04978.12 KOO29127.1 - 0.12 12.7 0.2 0.32 11.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF664) DUF2475 PF10629.9 KOO29131.1 - 0.0059 16.8 0.7 2.2 8.6 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) CNDH2_N PF06278.11 KOO29132.1 - 2.8e-37 127.4 0.9 6.6e-37 126.2 0.9 1.7 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal CNDH2_C PF16858.5 KOO29132.1 - 2.1e-32 113.2 9.6 7.2e-24 85.2 0.1 3.6 3 1 1 4 4 4 3 Condensin II complex subunit CAP-H2 or CNDH2, C-term Cnd2 PF05786.14 KOO29132.1 - 0.0012 17.7 3.1 0.0013 17.5 0.2 2.0 2 0 0 2 2 2 1 Condensin complex subunit 2 DUF2780 PF11075.8 KOO29132.1 - 0.044 13.9 0.3 0.095 12.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function VcgC/VcgE (DUF2780) ECH_1 PF00378.20 KOO29133.1 - 1.5e-79 266.9 0.4 1.7e-79 266.7 0.4 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOO29133.1 - 2.5e-39 135.7 2.0 6.5e-37 127.8 0.6 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase TetR_C_9 PF14514.6 KOO29133.1 - 0.021 15.0 0.1 0.21 11.7 0.0 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Cupin_8 PF13621.6 KOO29134.1 - 1.9e-25 90.0 0.0 2.3e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO29134.1 - 0.0016 18.0 0.2 0.015 14.8 0.1 2.3 2 1 0 2 2 2 1 Cupin superfamily protein Peptidase_A22B PF04258.13 KOO29135.1 - 9.1e-80 268.2 10.7 1.1e-79 267.9 10.7 1.1 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 KOO29135.1 - 5.9e-05 22.7 11.2 5.9e-05 22.7 11.2 2.6 2 1 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease LRR_9 PF14580.6 KOO29137.1 - 5.6e-63 211.6 13.1 1.2e-17 64.0 1.0 7.7 3 2 3 6 6 6 6 Leucine-rich repeat LRR_4 PF12799.7 KOO29137.1 - 6e-49 163.2 65.6 3.8e-07 30.3 1.0 15.0 11 3 7 18 18 18 14 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO29137.1 - 7.5e-41 137.7 81.6 1.5e-07 31.0 1.3 12.7 11 3 4 15 15 15 11 Leucine rich repeat Macoilin PF09726.9 KOO29137.1 - 0.11 11.0 0.1 0.2 10.2 0.1 1.3 1 0 0 1 1 1 0 Macoilin family BORCS6 PF10157.9 KOO29138.1 - 1.8e-11 44.5 0.3 2e-11 44.3 0.3 1.0 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 DUF2388 PF09498.10 KOO29138.1 - 0.035 14.1 0.8 0.055 13.5 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) AAA PF00004.29 KOO29139.1 - 2.1e-43 147.9 0.0 5e-43 146.7 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KOO29139.1 - 1e-11 44.6 0.0 7.8e-11 41.8 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 KOO29139.1 - 4.1e-08 33.3 0.2 1.8e-07 31.3 0.1 2.1 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO29139.1 - 1.2e-07 32.2 0.1 8.5e-05 23.0 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_lid_3 PF17862.1 KOO29139.1 - 1.3e-07 31.3 0.0 3.6e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 KOO29139.1 - 1.1e-06 28.9 0.1 3.5e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOO29139.1 - 1e-05 25.9 1.2 0.0096 16.2 0.0 2.9 2 1 1 3 3 2 2 AAA domain DUF815 PF05673.13 KOO29139.1 - 3.4e-05 23.1 0.0 7.4e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KOO29139.1 - 0.00018 21.3 0.0 0.00043 20.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 KOO29139.1 - 0.00045 20.5 0.0 0.0013 19.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 KOO29139.1 - 0.00067 19.0 0.0 0.0023 17.2 0.0 1.7 1 1 1 2 2 2 1 TIP49 P-loop domain IstB_IS21 PF01695.17 KOO29139.1 - 0.00068 19.4 0.0 0.0017 18.1 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KOO29139.1 - 0.0011 19.3 0.0 0.0058 17.0 0.0 2.2 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 KOO29139.1 - 0.0014 19.1 0.0 0.0054 17.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 KOO29139.1 - 0.0017 17.8 0.1 0.0038 16.6 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 KOO29139.1 - 0.0039 16.8 0.0 0.024 14.3 0.0 2.1 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain AAA_33 PF13671.6 KOO29139.1 - 0.0045 17.1 0.0 0.01 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KOO29139.1 - 0.0056 16.4 0.1 0.017 14.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO29139.1 - 0.0067 16.2 0.6 0.023 14.4 0.3 2.1 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 KOO29139.1 - 0.0069 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 KOO29139.1 - 0.011 15.3 0.1 0.067 12.7 0.1 2.0 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 KOO29139.1 - 0.011 15.3 2.6 0.026 14.1 0.7 2.2 2 1 1 3 3 3 0 AAA domain NACHT PF05729.12 KOO29139.1 - 0.015 15.2 0.1 0.096 12.6 0.1 2.2 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.15 KOO29139.1 - 0.017 15.1 0.1 0.097 12.6 0.0 2.2 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 KOO29139.1 - 0.017 15.2 0.0 0.044 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 KOO29139.1 - 0.021 13.9 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 KOO29139.1 - 0.024 14.4 0.1 0.17 11.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 KOO29139.1 - 0.036 13.9 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 KOO29139.1 - 0.04 13.3 0.0 1.9 7.9 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein ATPase PF06745.13 KOO29139.1 - 0.089 12.1 0.5 0.45 9.8 0.0 2.2 3 0 0 3 3 3 0 KaiC AAA_11 PF13086.6 KOO29139.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain PhoH PF02562.16 KOO29139.1 - 0.12 11.8 0.1 0.25 10.8 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein ATPase_2 PF01637.18 KOO29139.1 - 0.14 12.0 0.4 2.5 7.9 0.0 2.4 2 1 1 3 3 2 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 KOO29139.1 - 0.18 12.1 0.2 0.62 10.4 0.1 1.9 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.27 KOO29139.1 - 0.19 12.2 0.0 1.5 9.3 0.0 2.4 3 0 0 3 3 2 0 ABC transporter HIP1_clath_bdg PF16515.5 KOO29139.1 - 0.22 12.2 1.4 0.87 10.2 0.4 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 GSHPx PF00255.19 KOO29140.1 - 0.00014 21.4 0.0 0.00018 21.0 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase SAD_SRA PF02182.17 KOO29141.1 - 2.4e-14 53.3 0.0 3.3e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 SAD/SRA domain PsbU PF06514.11 KOO29142.1 - 4.2e-20 71.5 0.2 5.6e-20 71.1 0.2 1.2 1 0 0 1 1 1 1 Photosystem II 12 kDa extrinsic protein (PsbU) HHH_3 PF12836.7 KOO29142.1 - 0.00078 19.6 0.2 0.0052 17.0 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif GSHPx PF00255.19 KOO29143.1 - 6.8e-17 61.0 0.0 9.2e-17 60.6 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase ATP-grasp_4 PF13535.6 KOO29144.1 - 8.3e-14 51.5 0.0 1.4e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 KOO29144.1 - 1.1e-09 38.5 0.0 1.8e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 KOO29144.1 - 1.2e-06 28.5 0.0 2e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_Ter PF15632.6 KOO29144.1 - 3.6e-05 23.5 0.0 0.00015 21.5 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.11 KOO29144.1 - 0.0052 16.4 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain LAL_C2 PF18603.1 KOO29144.1 - 0.1 12.7 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 L-amino acid ligase C-terminal domain 2 Ion_trans_2 PF07885.16 KOO29146.1 - 1.1e-21 76.6 14.4 1.1e-10 41.3 5.5 2.3 2 0 0 2 2 2 2 Ion channel MORN PF02493.20 KOO29146.1 - 3.7e-11 42.2 14.7 1.1e-08 34.5 0.4 3.9 4 0 0 4 4 4 2 MORN repeat EF-hand_5 PF13202.6 KOO29146.1 - 4.2e-05 22.8 0.3 4.2e-05 22.8 0.3 2.0 2 0 0 2 2 2 1 EF hand Ion_trans PF00520.31 KOO29146.1 - 0.0007 18.9 0.9 0.0007 18.9 0.9 2.2 2 0 0 2 2 2 1 Ion transport protein EF-hand_7 PF13499.6 KOO29146.1 - 0.003 18.0 0.0 0.0077 16.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO29146.1 - 0.0036 17.1 0.1 0.0036 17.1 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO29146.1 - 0.0046 16.4 0.0 0.0046 16.4 0.0 2.2 2 0 0 2 2 2 1 EF hand DUF4956 PF16316.5 KOO29146.1 - 0.044 13.4 0.9 0.074 12.7 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) Ni_hydr_CYTB PF01292.20 KOO29146.1 - 0.06 12.9 5.7 0.09 12.4 5.7 1.3 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Fumarate_red_C PF02300.17 KOO29146.1 - 8.8 6.4 6.7 58 3.8 6.7 2.0 1 1 0 1 1 1 0 Fumarate reductase subunit C Rossmann-like PF10727.9 KOO29147.1 - 0.11 12.4 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Rossmann-like domain PALP PF00291.25 KOO29149.1 - 6.8e-78 262.0 5.4 9.8e-78 261.5 5.4 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 KOO29149.1 - 2.3e-31 107.4 0.0 2.9e-18 65.4 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase SNARE_assoc PF09335.11 KOO29150.1 - 4.1e-13 49.9 6.2 4.1e-13 49.9 6.2 2.2 2 1 1 3 3 3 1 SNARE associated Golgi protein MrpF_PhaF PF04066.13 KOO29150.1 - 0.54 10.7 0.2 0.54 10.7 0.2 2.6 3 0 0 3 3 3 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) DAO PF01266.24 KOO29151.1 - 3.2e-10 40.1 0.9 1.1e-06 28.5 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase ArfGap PF01412.18 KOO29152.1 - 2e-18 66.6 12.8 2.6e-13 50.1 3.3 2.1 1 1 1 2 2 2 2 Putative GTPase activating protein for Arf DUF1492 PF07374.11 KOO29152.1 - 0.13 12.5 0.1 23 5.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) PhnA_Zn_Ribbon PF08274.12 KOO29152.1 - 2.1 8.4 12.0 9 6.3 0.1 4.0 4 0 0 4 4 4 0 PhnA Zinc-Ribbon OS-D PF03392.13 KOO29152.1 - 5.6 7.1 15.3 3.3 7.9 2.4 2.9 2 2 1 3 3 3 0 Insect pheromone-binding family, A10/OS-D zf-HIT PF04438.16 KOO29152.1 - 7.4 6.5 11.0 60 3.6 0.2 4.2 4 0 0 4 4 4 0 HIT zinc finger Filamin PF00630.19 KOO29154.1 - 2.1e-81 269.4 0.0 1.2e-10 42.2 0.0 10.3 9 1 0 9 9 9 9 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO29154.1 - 4e-15 55.9 0.0 2.3e-05 24.6 0.0 6.7 7 0 0 7 7 7 2 Invasin, domain 3 YtkA PF13115.6 KOO29154.1 - 4.8e-06 27.1 0.2 1.1 9.9 0.1 6.0 6 0 0 6 6 6 1 YtkA-like Big_1 PF02369.16 KOO29154.1 - 0.00012 22.0 0.0 0.81 9.7 0.0 6.0 7 0 0 7 7 7 1 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.12 KOO29154.1 - 0.0033 16.9 0.0 0.08 12.4 0.0 2.8 3 0 0 3 3 3 1 Neurexophilin Cadherin_5 PF17892.1 KOO29154.1 - 0.034 14.1 1.5 15 5.6 0.0 3.9 4 0 0 4 4 4 0 Cadherin-like domain Big_3_5 PF16640.5 KOO29154.1 - 5.5 7.3 6.2 48 4.2 0.5 4.1 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) EF-hand_7 PF13499.6 KOO29155.1 - 8.4e-24 83.8 7.1 2.4e-09 37.5 0.4 3.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 KOO29155.1 - 7.2e-22 75.3 2.1 2.8e-06 26.5 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 KOO29155.1 - 1.3e-20 71.9 2.3 2.5e-06 26.7 0.2 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO29155.1 - 3.5e-19 67.0 0.9 1.1e-05 24.9 0.0 3.9 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 KOO29155.1 - 1.3e-13 50.6 1.1 0.0019 18.0 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO29155.1 - 2.7e-06 27.7 0.9 0.0058 16.9 0.2 3.0 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO29155.1 - 0.00087 19.2 0.4 0.73 9.8 0.1 2.8 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO29155.1 - 0.0011 19.3 0.0 0.055 13.8 0.0 2.6 2 1 0 2 2 2 1 EF-hand domain p25-alpha PF05517.12 KOO29155.1 - 0.01 16.0 1.8 0.48 10.6 0.0 2.2 2 0 0 2 2 2 0 p25-alpha EF-hand_10 PF14788.6 KOO29155.1 - 0.088 12.7 1.3 14 5.6 0.0 3.2 2 1 1 3 3 3 0 EF hand DUF1840 PF08895.11 KOO29155.1 - 0.14 12.5 9.2 1.4 9.2 0.1 4.3 1 1 3 5 5 5 0 Domain of unknown function (DUF1840) MT-A70 PF05063.14 KOO29157.1 - 1.3e-57 194.4 0.1 2e-57 193.8 0.1 1.3 1 0 0 1 1 1 1 MT-A70 Spc7 PF08317.11 KOO29159.1 - 0.0022 16.9 9.6 0.0022 16.9 9.6 2.1 1 1 1 2 2 2 1 Spc7 kinetochore protein BLOC1_2 PF10046.9 KOO29159.1 - 0.54 10.6 4.3 1.2 9.5 0.4 2.7 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HALZ PF02183.18 KOO29159.1 - 0.6 10.4 4.0 37 4.6 0.0 3.7 4 0 0 4 4 4 0 Homeobox associated leucine zipper GAS PF13851.6 KOO29159.1 - 1.3 8.3 14.3 0.85 8.9 12.1 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.9 KOO29159.1 - 2.4 7.1 8.6 4.2 6.4 8.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SlyX PF04102.12 KOO29159.1 - 5.7 7.6 7.8 21 5.8 1.1 3.2 1 1 0 2 2 2 0 SlyX Fez1 PF06818.15 KOO29159.1 - 6.4 7.2 14.9 3.9 7.9 12.4 1.8 1 1 0 1 1 1 0 Fez1 EF-hand_7 PF13499.6 KOO29160.1 - 2.7e-16 59.8 0.4 3.7e-08 33.7 0.1 2.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO29160.1 - 2.2e-14 51.9 0.3 4.1e-06 26.0 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO29160.1 - 6.7e-13 47.5 0.5 2.1e-05 23.8 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO29160.1 - 2e-12 46.0 0.0 8.8e-05 22.1 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO29160.1 - 1.5e-09 37.5 0.3 8e-06 25.6 0.2 2.3 1 1 1 2 2 2 2 EF-hand domain pair p25-alpha PF05517.12 KOO29160.1 - 0.0059 16.8 0.4 0.024 14.8 0.1 2.1 1 1 2 3 3 3 1 p25-alpha EF-hand_9 PF14658.6 KOO29160.1 - 0.0067 16.7 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain DUF3486 PF11985.8 KOO29160.1 - 0.036 14.5 0.9 0.14 12.5 0.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3486) Sec1 PF00995.23 KOO29161.1 - 2e-100 337.7 0.0 2.2e-100 337.6 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Ion_trans PF00520.31 KOO29162.1 - 3.2e-14 52.8 1.7 5e-14 52.1 1.7 1.3 1 0 0 1 1 1 1 Ion transport protein Pkinase PF00069.25 KOO29163.1 - 3.7e-52 177.3 0.0 6.1e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29163.1 - 7.8e-28 97.5 0.0 1.3e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Formyl_trans_N PF00551.19 KOO29163.1 - 0.1 12.3 0.0 0.36 10.6 0.0 1.8 2 0 0 2 2 2 0 Formyl transferase PI3K_C2 PF00792.24 KOO29164.1 - 0.0035 17.2 0.0 0.18 11.7 0.0 3.2 3 0 0 3 3 3 1 Phosphoinositide 3-kinase C2 PDZ_6 PF17820.1 KOO29165.1 - 1.9e-05 24.4 0.2 4e-05 23.4 0.2 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO29165.1 - 0.0004 20.7 0.0 0.00085 19.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Arginase PF00491.21 KOO29165.1 - 0.077 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Arginase family TIG PF01833.24 KOO29167.1 - 4.4e-09 36.3 9.5 0.00044 20.3 0.3 5.4 5 1 0 5 5 5 3 IPT/TIG domain CBM_X2 PF03442.14 KOO29167.1 - 0.017 15.2 0.1 0.043 13.9 0.0 1.7 2 0 0 2 2 2 0 Carbohydrate binding domain X2 OGFr_III PF04680.13 KOO29167.1 - 6.4 7.6 6.1 4.4 8.1 1.3 3.2 2 0 0 2 2 2 0 Opioid growth factor receptor repeat DnaJ PF00226.31 KOO29168.1 - 7.8e-11 42.0 1.6 7.8e-11 42.0 1.6 2.0 2 0 0 2 2 2 1 DnaJ domain DEK_C PF08766.11 KOO29168.1 - 1.6e-09 37.5 2.5 2.6e-09 36.8 0.2 2.4 2 0 0 2 2 2 1 DEK C terminal domain Chromo PF00385.24 KOO29168.1 - 1.3e-07 31.4 0.0 3.2e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ABC1 PF03109.16 KOO29169.1 - 5.4e-22 78.2 0.0 1.2e-21 77.1 0.0 1.6 1 0 0 1 1 1 1 ABC1 family SCP2 PF02036.17 KOO29169.1 - 2.6e-09 37.5 0.0 8.2e-09 35.9 0.0 1.9 1 0 0 1 1 1 1 SCP-2 sterol transfer family Beta-lactamase PF00144.24 KOO29169.1 - 1.9e-05 24.1 0.1 5.7e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase Pkinase PF00069.25 KOO29169.1 - 0.00023 20.6 0.0 0.00037 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PX PF00787.24 KOO29169.1 - 0.0003 20.7 0.0 0.00067 19.6 0.0 1.5 1 0 0 1 1 1 1 PX domain SCP2_2 PF13530.6 KOO29169.1 - 0.014 15.8 0.1 5 7.6 0.0 3.0 2 1 1 3 3 3 0 Sterol carrier protein domain Alkyl_sulf_C PF14864.6 KOO29169.1 - 0.05 13.9 0.0 0.2 11.9 0.0 2.1 3 0 0 3 3 3 0 Alkyl sulfatase C-terminal APH PF01636.23 KOO29169.1 - 0.41 10.5 6.2 0.13 12.2 1.6 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family Rep-A_N PF04057.12 KOO29170.1 - 9.4e-09 35.2 0.0 2.8e-08 33.7 0.0 1.8 1 1 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain DUF5521 PF17659.1 KOO29170.1 - 4.7e-06 24.8 0.0 0.054 11.3 0.0 2.1 2 0 0 2 2 2 2 Family of unknown function (DUF5521) tRNA_anti-codon PF01336.25 KOO29170.1 - 0.0057 16.6 0.0 0.3 11.1 0.0 2.5 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Chromo PF00385.24 KOO29171.1 - 0.11 12.4 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Methyltransf_21 PF05050.12 KOO29172.1 - 2.5e-06 27.6 0.0 2.9e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain adh_short PF00106.25 KOO29173.1 - 1.5e-09 37.6 0.0 4.2e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase Kinesin PF00225.23 KOO29174.1 - 4.2e-82 275.8 0.1 4.6e-82 275.6 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO29174.1 - 1.6e-30 106.0 0.0 2.8e-30 105.2 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding PIF1 PF05970.14 KOO29174.1 - 0.075 12.2 0.4 0.14 11.3 0.4 1.3 1 0 0 1 1 1 0 PIF1-like helicase AAA_19 PF13245.6 KOO29174.1 - 0.19 12.0 0.2 10 6.5 0.1 2.4 1 1 0 2 2 2 0 AAA domain PRKG1_interact PF15898.5 KOO29175.1 - 0.064 14.2 8.7 0.89 10.5 7.7 2.4 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain THOC7 PF05615.13 KOO29175.1 - 0.12 12.7 13.0 0.084 13.2 3.4 2.4 2 1 0 2 2 2 0 Tho complex subunit 7 Alpha-E PF04168.12 KOO29175.1 - 0.17 11.6 4.2 0.37 10.5 4.2 1.5 1 1 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. SlyX PF04102.12 KOO29175.1 - 0.2 12.3 6.6 3 8.5 1.1 3.2 3 0 0 3 3 3 0 SlyX DUF2353 PF09789.9 KOO29175.1 - 0.21 10.9 9.1 0.37 10.1 9.1 1.4 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Exonuc_VII_L PF02601.15 KOO29175.1 - 0.29 10.7 6.6 0.61 9.6 6.6 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit FTA4 PF13093.6 KOO29175.1 - 0.48 10.3 5.4 0.087 12.7 1.4 1.7 2 0 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Occludin_ELL PF07303.13 KOO29175.1 - 1.7 9.4 5.2 0.86 10.4 2.0 2.1 2 1 0 2 2 1 0 Occludin homology domain 3-PAP PF12578.8 KOO29175.1 - 2.3 8.0 5.7 0.42 10.4 0.4 2.4 3 1 0 3 3 3 0 Myotubularin-associated protein Gp-FAR-1 PF05823.12 KOO29175.1 - 2.3 8.5 7.2 4.7 7.5 7.2 1.5 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Yuri_gagarin PF15934.5 KOO29175.1 - 2.4 7.9 9.2 18 5.1 0.1 2.4 2 1 0 2 2 2 0 Yuri gagarin DUF4618 PF15397.6 KOO29175.1 - 2.7 7.4 10.3 3.4 7.0 1.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4618) BST2 PF16716.5 KOO29175.1 - 3.2 8.4 13.6 0.24 12.0 4.7 2.7 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 Seryl_tRNA_N PF02403.22 KOO29175.1 - 4.2 7.7 17.7 1.6 9.0 11.7 2.9 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Spc42p PF11544.8 KOO29175.1 - 4.2 7.4 10.2 1.4 8.9 0.5 3.3 3 1 0 3 3 3 0 Spindle pole body component Spc42p Med9 PF07544.13 KOO29175.1 - 6.6 6.9 13.7 3.3 7.9 0.9 2.6 3 0 0 3 3 2 0 RNA polymerase II transcription mediator complex subunit 9 Arm PF00514.23 KOO29176.1 - 1.2e-25 88.7 11.9 1.4e-06 28.1 0.0 5.4 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO29176.1 - 0.0052 17.1 6.3 0.3 11.5 0.1 3.5 3 1 1 4 4 4 2 HEAT repeats Arm_2 PF04826.13 KOO29176.1 - 0.014 14.8 0.0 0.48 9.8 0.0 2.5 1 1 1 2 2 2 0 Armadillo-like HEAT_EZ PF13513.6 KOO29176.1 - 0.022 15.3 14.8 0.1 13.1 0.1 5.5 5 1 2 7 7 7 0 HEAT-like repeat HEAT PF02985.22 KOO29176.1 - 0.1 12.9 1.6 52 4.5 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat adh_short PF00106.25 KOO29177.1 - 9.3e-22 77.4 0.0 8.3e-19 67.8 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO29177.1 - 9.5e-08 31.9 0.0 1.4e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO29177.1 - 0.0021 18.0 0.0 0.0033 17.4 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF5300 PF17224.3 KOO29177.1 - 0.018 15.3 0.1 0.066 13.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5300) Thioredoxin_6 PF13848.6 KOO29178.1 - 0.00037 20.5 0.0 0.00043 20.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain FA_desaturase PF00487.24 KOO29180.1 - 6.8e-28 98.2 27.2 6.8e-28 98.2 27.2 1.9 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 KOO29180.1 - 3e-20 72.1 0.0 6.5e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PDEase_I PF00233.19 KOO29180.1 - 0.16 11.6 1.0 0.32 10.7 0.9 1.5 1 1 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase Melibiase_2 PF16499.5 KOO29181.1 - 1.5e-57 194.9 0.8 3.1e-57 193.9 0.8 1.5 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 KOO29181.1 - 6.9e-09 35.7 0.0 2.5e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 KOO29181.1 - 0.00018 20.6 0.0 0.00029 19.9 0.0 1.2 1 0 0 1 1 1 1 Melibiase Melibiase_2_C PF17450.2 KOO29181.1 - 0.026 14.7 0.0 0.082 13.1 0.0 1.8 2 0 0 2 2 2 0 Alpha galactosidase A C-terminal beta sandwich domain Pirin PF02678.16 KOO29182.1 - 3.2e-30 104.3 0.4 5.4e-30 103.5 0.4 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 KOO29182.1 - 1.6e-22 79.8 0.0 3e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Ion_trans PF00520.31 KOO29183.1 - 9.9e-30 103.6 6.3 1.9e-29 102.6 6.3 1.5 1 0 0 1 1 1 1 Ion transport protein MFS_1 PF07690.16 KOO29183.1 - 3.1e-14 52.7 37.2 3.1e-14 52.7 37.2 3.0 2 2 2 4 4 4 2 Major Facilitator Superfamily PKD_channel PF08016.12 KOO29183.1 - 0.096 11.3 14.3 0.096 11.3 9.7 2.5 2 1 0 2 2 2 0 Polycystin cation channel Nucleotid_trans PF03407.16 KOO29184.1 - 1.7e-09 38.0 0.0 3.1e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_hydro_127 PF07944.12 KOO29185.1 - 5.7e-20 71.3 0.0 7.2e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Peptidase_M14 PF00246.24 KOO29186.1 - 2.9e-14 53.6 0.0 8.3e-14 52.1 0.0 1.6 1 1 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 KOO29186.1 - 4e-07 30.4 0.0 7.6e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain VKOR PF07884.14 KOO29187.1 - 2e-21 76.5 12.5 3.7e-21 75.6 12.5 1.4 1 0 0 1 1 1 1 Vitamin K epoxide reductase family TEX13 PF15186.6 KOO29189.1 - 0.44 10.2 3.1 0.69 9.6 3.1 1.2 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family HET PF06985.11 KOO29190.1 - 0.16 12.3 0.4 0.94 9.8 0.0 2.3 2 1 0 3 3 3 0 Heterokaryon incompatibility protein (HET) DUF1764 PF08576.10 KOO29193.1 - 2.2e-17 63.8 0.7 2.2e-17 63.8 0.7 2.4 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF1764) DUF1387 PF07139.11 KOO29193.1 - 0.034 13.9 4.6 0.037 13.8 4.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Med3 PF11593.8 KOO29193.1 - 0.87 8.7 10.0 0.97 8.6 10.0 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal LPP PF04728.13 KOO29193.1 - 4.8 7.6 9.8 12 6.4 9.8 1.7 1 0 0 1 1 1 0 Lipoprotein leucine-zipper WW PF00397.26 KOO29194.1 - 7.3e-06 26.0 0.9 0.013 15.6 0.0 3.5 3 0 0 3 3 3 2 WW domain IQ PF00612.27 KOO29194.1 - 0.032 14.0 1.9 0.87 9.6 0.4 3.2 2 0 0 2 2 2 0 IQ calmodulin-binding motif Cupin_8 PF13621.6 KOO29195.1 - 5.2e-31 108.3 0.1 9e-31 107.5 0.1 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO29195.1 - 1.1e-06 28.3 0.7 4e-06 26.5 0.7 2.0 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 KOO29195.1 - 0.035 13.8 0.0 0.084 12.6 0.0 1.6 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.22 KOO29195.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Cupin KH_1 PF00013.29 KOO29197.1 - 9.5e-05 22.1 0.0 0.00018 21.3 0.0 1.4 1 0 0 1 1 1 1 KH domain ADH_zinc_N_2 PF13602.6 KOO29198.1 - 3.9e-15 57.1 0.0 1.2e-14 55.5 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOO29198.1 - 1.3e-09 38.1 0.0 2.7e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOO29198.1 - 1.9e-05 24.5 0.0 9e-05 22.3 0.0 2.0 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain RNA_pol_A_bac PF01000.26 KOO29199.1 - 8.2e-29 100.2 0.0 2.3e-28 98.8 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KOO29199.1 - 1.1e-18 66.4 0.0 2.6e-18 65.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain MORN PF02493.20 KOO29199.1 - 5.2e-16 57.5 9.8 1.3e-05 24.8 0.3 3.8 4 0 0 4 4 4 3 MORN repeat NAD_binding_8 PF13450.6 KOO29201.1 - 8.1e-08 32.4 0.7 2.7e-07 30.7 0.7 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KOO29201.1 - 1.5e-05 24.5 7.7 0.024 13.9 0.1 3.0 1 1 0 2 2 2 2 Flavin containing amine oxidoreductase Radical_SAM PF04055.21 KOO29202.1 - 3e-16 60.3 0.0 5.2e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 KOO29202.1 - 2.5e-06 27.8 0.0 6e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 KOO29202.1 - 0.0037 17.4 0.0 0.013 15.6 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain SelR PF01641.18 KOO29203.1 - 0.0024 17.9 0.6 0.015 15.4 0.6 2.2 1 1 0 1 1 1 1 SelR domain HSDR_N PF04313.14 KOO29204.1 - 0.044 13.7 0.9 0.056 13.4 0.9 1.1 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) FUSC PF04632.12 KOO29204.1 - 0.24 9.9 18.7 0.26 9.8 18.7 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family PhnG PF06754.12 KOO29205.1 - 0.012 15.6 0.3 0.025 14.5 0.3 1.5 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnG DUF4515 PF14988.6 KOO29206.1 - 1.1e-10 41.7 38.6 1.1e-10 41.7 38.6 2.8 2 1 0 3 3 3 1 Domain of unknown function (DUF4515) Pkinase PF00069.25 KOO29208.1 - 5e-56 190.0 0.0 3.4e-49 167.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29208.1 - 8.5e-56 189.1 0.0 5.1e-55 186.5 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Arf PF00025.21 KOO29208.1 - 1.2e-42 145.4 0.0 2.9e-42 144.1 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KOO29208.1 - 2.8e-08 33.4 0.0 4.7e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KOO29208.1 - 3.9e-07 29.6 0.0 0.00085 18.6 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 KOO29208.1 - 5.9e-07 29.6 0.0 1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 KOO29208.1 - 2.2e-05 24.6 0.0 4.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO29208.1 - 7.5e-05 22.4 0.0 0.00012 21.7 0.0 1.3 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KOO29208.1 - 0.00017 21.0 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SH3_1 PF00018.28 KOO29208.1 - 0.00021 20.8 0.0 0.00042 19.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KOO29208.1 - 0.0012 18.5 0.0 0.0024 17.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOO29208.1 - 0.0088 15.9 0.7 0.059 13.2 0.7 2.2 1 1 0 1 1 1 1 Variant SH3 domain Kdo PF06293.14 KOO29208.1 - 0.064 12.6 0.1 5.7 6.2 0.0 2.4 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family GTP_EFTU PF00009.27 KOO29208.1 - 0.093 12.3 0.0 0.89 9.1 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Methyltransf_25 PF13649.6 KOO29209.1 - 6.9e-10 39.5 0.3 1.9e-06 28.5 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 KOO29209.1 - 1e-09 38.9 0.1 1.7e-07 31.8 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO29209.1 - 8.1e-09 36.1 0.0 1e-07 32.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO29209.1 - 1.4e-08 34.7 0.1 2.9e-08 33.7 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO29209.1 - 2.1e-07 30.8 0.2 3e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_28 PF02636.17 KOO29209.1 - 0.014 15.0 0.1 2.5 7.6 0.0 3.0 2 1 0 3 3 3 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 KOO29209.1 - 0.073 12.6 0.1 11 5.5 0.1 2.4 2 1 0 2 2 2 0 Methyltransferase small domain SecE PF00584.20 KOO29210.1 - 5.3e-16 58.3 0.2 6.9e-16 57.9 0.2 1.2 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Agenet PF05641.12 KOO29211.1 - 0.1 13.0 0.0 6.6 7.3 0.0 2.6 2 0 0 2 2 2 0 Agenet domain TUDOR PF00567.24 KOO29211.1 - 0.2 11.7 0.0 2.3 8.3 0.0 2.2 1 1 1 2 2 2 0 Tudor domain VPS9 PF02204.18 KOO29212.1 - 1.1e-13 51.3 0.9 1.2e-13 51.1 0.2 1.5 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain 2OG-FeII_Oxy_3 PF13640.6 KOO29213.1 - 6.2e-16 59.1 0.0 1.7e-15 57.7 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO29213.1 - 0.015 15.8 3.3 0.026 15.1 3.3 1.4 1 0 0 1 1 1 0 ShK domain-like 2OG-FeII_Oxy_4 PF13661.6 KOO29213.1 - 0.19 12.4 0.0 0.38 11.4 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily CBFD_NFYB_HMF PF00808.23 KOO29214.1 - 3.3e-07 30.5 0.0 5.1e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Mg_trans_NIPA PF05653.14 KOO29215.1 - 1.4e-18 67.0 7.9 2e-18 66.5 7.9 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA Multi_Drug_Res PF00893.19 KOO29215.1 - 1.7 9.4 7.9 0.19 12.4 0.7 2.9 2 2 0 2 2 2 0 Small Multidrug Resistance protein MatE PF01554.18 KOO29216.1 - 7.4e-13 48.5 8.0 7.4e-13 48.5 8.0 3.7 5 0 0 5 5 5 2 MatE FKBP_C PF00254.28 KOO29216.1 - 1.1e-07 32.1 0.0 1.9e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase RSN1_7TM PF02714.15 KOO29217.1 - 3.1e-05 23.4 1.3 6.2e-05 22.5 1.3 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate Anoctamin PF04547.12 KOO29217.1 - 0.0012 17.8 0.0 0.0028 16.6 0.0 1.5 1 1 0 1 1 1 1 Calcium-activated chloride channel PHM7_cyt PF14703.6 KOO29217.1 - 0.11 12.7 5.4 0.14 12.3 0.0 2.9 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter ERM PF00769.19 KOO29217.1 - 1.3 8.7 27.1 0.1 12.4 18.3 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Filamin PF00630.19 KOO29218.1 - 9e-06 26.5 0.0 2.5e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 Filamin/ABP280 repeat T3SSipB PF16535.5 KOO29218.1 - 0.46 11.0 13.6 0.67 10.4 13.6 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB Spc7 PF08317.11 KOO29218.1 - 0.76 8.6 9.8 1 8.2 9.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Phage_cap_E PF03864.15 KOO29219.1 - 0.0024 17.1 0.5 0.0051 16.0 0.5 1.5 1 0 0 1 1 1 1 Phage major capsid protein E TMPIT PF07851.13 KOO29219.1 - 0.021 14.1 4.1 0.062 12.5 4.0 1.7 2 0 0 2 2 2 0 TMPIT-like protein Tho2 PF11262.8 KOO29219.1 - 0.12 11.6 6.1 0.13 11.4 5.3 1.3 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF1474 PF07342.11 KOO29219.1 - 0.15 12.6 0.8 16 6.1 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1474) Gly_acyl_tr_N PF06021.11 KOO29219.1 - 0.27 11.3 1.7 0.37 10.9 1.7 1.1 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase DUF4407 PF14362.6 KOO29219.1 - 0.29 10.4 11.4 0.35 10.2 11.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 KOO29219.1 - 0.87 9.7 9.0 1.2 9.2 9.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YlqD PF11068.8 KOO29219.1 - 2.1 8.7 10.8 0.59 10.5 6.5 2.0 1 1 1 2 2 2 0 YlqD protein MIF4G_like_2 PF09090.11 KOO29219.1 - 3.1 7.2 7.4 2 7.9 5.7 1.5 1 1 1 2 2 2 0 MIF4G like XhlA PF10779.9 KOO29219.1 - 6.5 7.0 6.8 34 4.7 4.6 2.7 1 1 1 2 2 2 0 Haemolysin XhlA FapA PF03961.13 KOO29219.1 - 7.1 5.1 11.7 3.2 6.2 8.6 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A TBCA PF02970.16 KOO29219.1 - 8.6 6.8 13.7 6.9 7.1 1.9 2.8 3 0 0 3 3 3 0 Tubulin binding cofactor A V-SNARE_C PF12352.8 KOO29221.1 - 5.1e-11 42.7 0.7 2.4e-10 40.6 0.2 2.3 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus DUF4201 PF13870.6 KOO29221.1 - 0.47 10.2 7.2 0.89 9.3 4.7 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) AP2 PF00847.20 KOO29222.1 - 0.001 19.2 7.6 0.11 12.7 0.1 4.3 3 1 0 3 3 3 2 AP2 domain Fez1 PF06818.15 KOO29223.1 - 2 8.8 14.6 3.4 8.1 2.4 3.1 2 1 1 3 3 3 0 Fez1 UPF0242 PF06785.11 KOO29223.1 - 3.7 7.6 5.5 26 4.8 0.0 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus CCDC158 PF15921.5 KOO29223.1 - 4.3 5.0 10.0 0.42 8.4 1.2 2.4 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 158 HSNSD PF12062.8 KOO29224.1 - 0.002 16.9 0.0 0.0027 16.5 0.0 1.1 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase GSHPx PF00255.19 KOO29225.1 - 5e-23 80.7 0.0 6.4e-23 80.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase S36_mt PF10937.8 KOO29226.1 - 4.3e-07 31.5 0.1 7e-07 30.8 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S36, mitochondrial Biotin_lipoyl PF00364.22 KOO29226.1 - 6.4e-06 25.9 0.2 9.3e-06 25.4 0.2 1.2 1 0 0 1 1 1 1 Biotin-requiring enzyme PYNP_C PF07831.13 KOO29226.1 - 0.092 12.4 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain Bestrophin PF01062.21 KOO29227.1 - 9.9e-13 48.1 0.1 9.9e-13 48.1 0.1 1.7 2 0 0 2 2 2 1 Bestrophin, RFP-TM, chloride channel HSBP1 PF06825.12 KOO29227.1 - 0.43 10.5 1.5 14 5.6 0.0 2.8 2 0 0 2 2 2 0 Heat shock factor binding protein 1 ATP-synt_C PF00137.21 KOO29228.1 - 2.6e-30 104.6 43.7 6.9e-20 71.1 13.8 2.9 3 0 0 3 3 3 2 ATP synthase subunit C Peptidase_C97 PF05903.14 KOO29228.1 - 5.6e-17 62.0 0.0 9.4e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain PT-VENN PF04829.13 KOO29228.1 - 9.2 6.4 6.5 1.5 8.9 1.7 2.2 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif YusW PF14039.6 KOO29230.1 - 0.031 14.8 0.4 0.089 13.3 0.4 1.9 1 1 0 1 1 1 0 YusW-like protein DUF4554 PF15091.6 KOO29230.1 - 5.3 5.8 6.0 12 4.7 6.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Tubulin PF00091.25 KOO29231.1 - 3.5e-61 206.9 0.0 5.4e-61 206.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOO29231.1 - 3e-47 159.9 0.1 4.6e-47 159.3 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain DUF4994 PF16385.5 KOO29231.1 - 0.00058 19.7 0.0 0.0019 18.1 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function Tubulin_3 PF14881.6 KOO29231.1 - 0.015 15.0 0.0 0.045 13.4 0.0 1.8 1 0 0 1 1 1 0 Tubulin domain Arm PF00514.23 KOO29232.1 - 1.4e-11 44.0 11.9 5.9e-05 23.0 0.2 6.4 6 1 0 6 6 6 2 Armadillo/beta-catenin-like repeat EF-hand_6 PF13405.6 KOO29232.1 - 1.1e-10 40.5 0.1 0.0001 22.0 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO29232.1 - 5.8e-10 38.0 0.7 0.0015 18.0 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO29232.1 - 2e-09 37.8 3.7 1.8e-06 28.3 0.2 3.0 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO29232.1 - 1e-06 28.5 0.2 0.00025 20.8 0.1 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO29232.1 - 1.5e-05 24.3 0.9 0.0095 15.4 0.0 2.9 3 0 0 3 3 3 2 EF hand Atx10homo_assoc PF09759.9 KOO29232.1 - 0.0017 18.3 0.0 0.67 10.0 0.0 3.3 4 0 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain EF-hand_10 PF14788.6 KOO29232.1 - 0.051 13.4 2.3 1.1 9.2 0.0 3.3 4 0 0 4 4 4 0 EF hand NusG PF02357.19 KOO29234.1 - 1.3e-12 48.1 0.2 2.7e-12 47.0 0.2 1.6 1 1 0 1 1 1 1 Transcription termination factor nusG Glyco_transf_10 PF00852.19 KOO29234.1 - 0.12 12.1 0.1 0.16 11.7 0.1 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 10 (fucosyltransferase) C-term Het-C PF07217.11 KOO29235.1 - 0.043 12.4 0.1 0.081 11.4 0.1 1.4 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C MAS20 PF02064.15 KOO29235.1 - 1.7 8.7 5.5 0.2 11.7 0.2 2.0 2 0 0 2 2 2 0 MAS20 protein import receptor PrmC_N PF17827.1 KOO29236.1 - 5.9e-17 62.0 0.3 1.4e-16 60.9 0.1 1.7 2 0 0 2 2 1 1 PrmC N-terminal domain MTS PF05175.14 KOO29236.1 - 1.4e-11 44.2 0.0 2.8e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 KOO29236.1 - 3.1e-11 43.3 0.0 4.2e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO29236.1 - 4.8e-11 43.2 0.0 1.4e-10 41.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO29236.1 - 2.8e-07 31.1 0.0 6.1e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO29236.1 - 2.8e-06 26.9 0.0 4.1e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 KOO29236.1 - 1.2e-05 26.0 0.0 3e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO29236.1 - 0.00011 22.0 0.0 0.00019 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KOO29236.1 - 0.00047 19.8 0.0 0.00068 19.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 KOO29236.1 - 0.00067 19.4 0.0 0.0017 18.1 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.6 KOO29236.1 - 0.0024 17.9 0.0 0.0039 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KOO29236.1 - 0.0065 16.4 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 KOO29236.1 - 0.013 15.3 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 KOO29236.1 - 0.032 14.0 0.0 0.048 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Eco57I PF07669.11 KOO29236.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 Eco57I restriction-modification methylase Methyltransf_4 PF02390.17 KOO29236.1 - 0.16 11.4 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase DUF2997 PF11211.8 KOO29237.1 - 2.2e-18 65.8 0.4 3.8e-18 65.0 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2997) Ion_trans PF00520.31 KOO29238.1 - 4.3e-36 124.4 11.5 5.9e-36 123.9 11.5 1.1 1 0 0 1 1 1 1 Ion transport protein EF-hand_1 PF00036.32 KOO29238.1 - 2.3e-06 26.8 0.1 8.5e-06 25.0 0.1 2.1 1 0 0 1 1 1 1 EF hand PKD_channel PF08016.12 KOO29238.1 - 1.4e-05 24.0 9.2 0.0037 16.0 1.9 2.2 2 0 0 2 2 2 2 Polycystin cation channel EF-hand_6 PF13405.6 KOO29238.1 - 2e-05 24.1 0.0 7.2e-05 22.4 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO29238.1 - 0.00019 20.8 0.0 0.00045 19.6 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO29238.1 - 0.0028 18.1 0.0 0.0093 16.4 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair Ni_hydr_CYTB PF01292.20 KOO29238.1 - 0.25 10.9 0.0 0.25 10.9 0.0 2.1 2 1 0 2 2 2 0 Prokaryotic cytochrome b561 SLATT_5 PF18160.1 KOO29239.1 - 0.16 11.3 0.8 1.4 8.2 0.1 2.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF962 PF06127.11 KOO29239.1 - 4.8 7.3 7.2 17 5.6 0.4 4.1 3 2 0 3 3 3 0 Protein of unknown function (DUF962) COG5 PF10392.9 KOO29240.1 - 1.9e-12 47.5 1.0 4.1e-12 46.4 1.0 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Sec8_exocyst PF04048.14 KOO29240.1 - 0.015 15.1 0.0 0.056 13.3 0.0 1.9 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain DUF489 PF04356.12 KOO29240.1 - 0.032 14.2 0.3 0.067 13.2 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF489) U-box PF04564.15 KOO29241.1 - 5.4e-34 116.2 0.1 1.4e-15 57.2 0.0 2.4 1 1 1 2 2 2 2 U-box domain TPR_2 PF07719.17 KOO29241.1 - 7.3e-12 44.4 11.2 0.09 12.9 0.0 10.1 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO29241.1 - 7.5e-12 44.5 0.4 0.072 12.9 0.0 8.0 10 0 0 10 10 10 3 Tetratricopeptide repeat zf-Nse PF11789.8 KOO29241.1 - 4.8e-07 29.5 0.0 0.046 13.6 0.0 2.5 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit TPR_14 PF13428.6 KOO29241.1 - 1.3e-06 28.7 40.1 0.51 11.3 1.5 11.8 9 2 2 12 12 11 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO29241.1 - 1.6e-05 25.0 3.8 10 6.7 0.1 7.9 10 0 0 10 10 8 1 Tetratricopeptide repeat zf-RING_UBOX PF13445.6 KOO29241.1 - 0.00045 20.2 0.2 2.3 8.3 0.0 3.1 3 0 0 3 3 3 2 RING-type zinc-finger zf-NOSIP PF15906.5 KOO29241.1 - 0.0013 18.8 0.0 1.6 9.0 0.0 2.8 3 0 0 3 3 3 2 Zinc-finger of nitric oxide synthase-interacting protein TPR_8 PF13181.6 KOO29241.1 - 0.0083 16.3 0.0 3 8.3 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat zf-rbx1 PF12678.7 KOO29241.1 - 0.009 16.3 0.0 7 7.0 0.0 2.6 2 0 0 2 2 2 2 RING-H2 zinc finger domain ANAPC3 PF12895.7 KOO29241.1 - 0.5 10.6 0.0 0.5 10.6 0.0 4.0 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 LRR_6 PF13516.6 KOO29242.1 - 2e-05 24.3 9.8 0.03 14.3 0.0 7.7 8 0 0 8 8 8 1 Leucine Rich repeat LRR_4 PF12799.7 KOO29242.1 - 0.08 13.4 4.1 89 3.7 0.0 6.5 4 2 3 8 8 8 0 Leucine Rich repeats (2 copies) SAM_Ste50p PF09235.10 KOO29242.1 - 0.26 11.6 7.2 38 4.6 0.0 5.4 5 2 2 7 7 7 0 Ste50p, sterile alpha motif LRR_1 PF00560.33 KOO29242.1 - 3.3 8.6 12.1 84 4.3 0.1 6.7 7 2 0 7 7 7 0 Leucine Rich Repeat GDP_Man_Dehyd PF16363.5 KOO29244.1 - 1.1e-156 521.3 0.0 1.3e-156 521.1 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOO29244.1 - 1.7e-72 243.8 0.0 2.2e-72 243.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOO29244.1 - 0.0052 15.9 0.0 0.0075 15.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KOO29244.1 - 0.14 11.2 0.0 0.33 10.1 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein SPRY PF00622.28 KOO29246.1 - 1.9e-09 37.7 0.0 5e-08 33.1 0.0 2.2 1 1 0 1 1 1 1 SPRY domain Peptidase_C2 PF00648.21 KOO29247.1 - 1.4e-62 211.4 0.0 3e-62 210.3 0.0 1.5 2 0 0 2 2 2 1 Calpain family cysteine protease zf-GRF PF06839.12 KOO29247.1 - 2.2e-11 43.7 2.3 4.1e-11 42.8 2.3 1.5 1 0 0 1 1 1 1 GRF zinc finger LRR_6 PF13516.6 KOO29249.1 - 1.6e-11 43.3 8.1 0.00025 20.8 1.0 4.2 4 0 0 4 4 4 3 Leucine Rich repeat PK PF00224.21 KOO29250.1 - 2.8e-120 401.4 1.7 3.9e-120 400.9 1.7 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KOO29250.1 - 1e-16 61.2 0.0 4.1e-16 59.3 0.0 2.0 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KOO29250.1 - 0.0096 15.1 0.8 0.044 12.9 0.9 2.0 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Pox_A_type_inc PF04508.12 KOO29251.1 - 0.045 13.6 9.5 2.5 8.1 1.2 4.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat LisH PF08513.11 KOO29252.1 - 3.1e-06 26.9 0.0 4.4e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 LisH SNARE_assoc PF09335.11 KOO29253.1 - 4.1e-05 24.0 2.7 4.1e-05 24.0 2.7 1.6 2 0 0 2 2 2 1 SNARE associated Golgi protein Pkinase PF00069.25 KOO29254.1 - 7.3e-56 189.4 0.0 9e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29254.1 - 2.1e-27 96.0 0.0 2.9e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO29254.1 - 0.027 13.8 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like NAD_binding_2 PF03446.15 KOO29255.1 - 1.1e-34 120.0 1.3 2.1e-34 119.0 1.3 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KOO29255.1 - 1.4e-22 80.2 2.6 2.8e-22 79.2 2.6 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase SK_channel PF03530.14 KOO29255.1 - 9.2e-11 41.7 0.2 2.6e-10 40.3 0.2 1.8 1 0 0 1 1 1 1 Calcium-activated SK potassium channel F420_oxidored PF03807.17 KOO29255.1 - 3e-07 30.9 0.0 6.5e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ion_trans_2 PF07885.16 KOO29255.1 - 3.9e-07 29.9 0.7 3.9e-07 29.9 0.7 2.4 2 0 0 2 2 2 1 Ion channel Shikimate_DH PF01488.20 KOO29255.1 - 4.8e-05 23.5 0.0 9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Ion_trans PF00520.31 KOO29255.1 - 0.0093 15.2 0.1 0.016 14.4 0.1 1.6 1 1 0 1 1 1 1 Ion transport protein YpsA PF06908.11 KOO29258.1 - 0.019 15.0 0.8 0.025 14.6 0.8 1.2 1 0 0 1 1 1 0 YspA SLOG family PDZ PF00595.24 KOO29258.1 - 0.071 13.5 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 PDZ domain p25-alpha PF05517.12 KOO29259.1 - 0.018 15.2 17.1 0.22 11.7 2.6 6.8 7 0 0 7 7 7 0 p25-alpha Ndufs5 PF10200.9 KOO29259.1 - 0.039 14.2 6.3 3.8 7.8 0.1 4.6 5 0 0 5 5 5 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa EF-hand_7 PF13499.6 KOO29259.1 - 0.11 13.0 3.5 1.6 9.2 0.0 5.1 6 0 0 6 6 6 0 EF-hand domain pair EF-hand_1 PF00036.32 KOO29259.1 - 0.37 10.4 14.3 46 3.9 0.0 8.1 8 0 0 8 8 8 0 EF hand Ion_trans_2 PF07885.16 KOO29260.1 - 1.3e-22 79.6 9.1 1.2e-13 50.8 1.2 2.2 2 0 0 2 2 2 2 Ion channel EF-hand_6 PF13405.6 KOO29260.1 - 0.001 18.8 7.3 0.0013 18.5 0.2 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 KOO29260.1 - 0.0056 17.1 0.2 0.36 11.3 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain pair Ion_trans PF00520.31 KOO29260.1 - 0.0083 15.4 7.3 0.26 10.5 0.1 2.5 3 0 0 3 3 3 2 Ion transport protein EF-hand_1 PF00036.32 KOO29260.1 - 0.069 12.7 11.0 0.14 11.8 0.3 3.5 3 0 0 3 3 3 0 EF hand EF-hand_5 PF13202.6 KOO29260.1 - 0.25 10.9 11.4 0.4 10.3 0.2 3.6 3 0 0 3 3 3 0 EF hand AAA_28 PF13521.6 KOO29261.1 - 2e-09 37.9 0.5 9.2e-09 35.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF390 PF04094.14 KOO29261.1 - 0.011 14.0 8.8 0.014 13.7 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) Alanine_zipper PF11839.8 KOO29261.1 - 0.1 13.0 14.7 0.21 12.0 14.7 1.5 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein TTL PF03133.15 KOO29262.1 - 9.4e-63 212.1 0.0 1.3e-62 211.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO29262.1 - 0.053 12.8 0.1 0.22 10.8 0.1 1.9 1 1 0 1 1 1 0 YheC/D like ATP-grasp TTL PF03133.15 KOO29263.1 - 4.7e-13 48.9 0.1 5.8e-13 48.6 0.1 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO29263.1 - 0.00063 19.1 0.0 0.00081 18.7 0.0 1.1 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO29263.1 - 0.002 17.4 0.0 0.0023 17.2 0.0 1.1 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp Myosin_head PF00063.21 KOO29264.1 - 1.1e-189 631.9 0.0 4.5e-111 372.2 0.0 2.0 2 0 0 2 2 2 2 Myosin head (motor domain) AAA_22 PF13401.6 KOO29264.1 - 0.00077 19.7 0.0 0.006 16.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO29264.1 - 0.0056 17.1 0.1 0.02 15.3 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 KOO29264.1 - 0.15 11.7 0.0 0.42 10.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain LRR_6 PF13516.6 KOO29265.1 - 0.00069 19.5 0.5 0.045 13.8 0.0 3.4 4 0 0 4 4 4 1 Leucine Rich repeat NACHT PF05729.12 KOO29265.1 - 0.012 15.6 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Methyltransf_21 PF05050.12 KOO29266.1 - 2.8e-09 37.2 0.0 4.5e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain V-SNARE_C PF12352.8 KOO29267.1 - 1.7e-13 50.6 0.9 1.7e-13 50.6 0.9 2.8 2 1 1 3 3 3 2 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 KOO29267.1 - 6.4e-11 42.5 0.7 6.4e-11 42.5 0.7 2.5 2 1 1 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 KOO29267.1 - 5.2e-05 23.1 0.1 0.0002 21.2 0.1 1.9 1 1 0 1 1 1 1 Sec20 Fusion_gly PF00523.18 KOO29267.1 - 0.018 13.3 0.3 0.05 11.9 0.1 1.8 1 1 1 2 2 2 0 Fusion glycoprotein F0 DUF4407 PF14362.6 KOO29267.1 - 0.022 14.1 5.7 0.032 13.6 5.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SF-assemblin PF06705.11 KOO29267.1 - 0.034 13.5 5.1 0.064 12.6 0.6 2.0 1 1 1 2 2 2 0 SF-assemblin/beta giardin DUF2130 PF09903.9 KOO29267.1 - 0.054 12.8 3.0 0.15 11.3 3.0 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) Tho2 PF11262.8 KOO29267.1 - 0.1 11.8 1.5 0.14 11.3 1.5 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Atg14 PF10186.9 KOO29267.1 - 0.13 11.4 3.1 0.15 11.2 3.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 KOO29267.1 - 0.23 11.8 8.2 0.38 11.1 8.2 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) HAUS-augmin3 PF14932.6 KOO29267.1 - 0.31 10.6 2.6 0.37 10.3 2.6 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Uso1_p115_C PF04871.13 KOO29267.1 - 0.71 10.2 11.8 4.4 7.7 10.6 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region V-ATPase_G_2 PF16999.5 KOO29267.1 - 3.2 8.2 13.8 2.7 8.5 9.2 2.3 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit PP-binding PF00550.25 KOO29268.1 - 4.1e-07 30.2 0.1 2.4e-06 27.8 0.0 2.3 2 0 0 2 2 2 1 Phosphopantetheine attachment site RNase_H PF00075.24 KOO29268.1 - 0.07 13.3 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 RNase H MarR_2 PF12802.7 KOO29268.1 - 0.086 12.7 0.1 0.33 10.9 0.1 2.0 1 0 0 1 1 1 0 MarR family RIB43A PF05914.12 KOO29269.1 - 0.042 12.6 18.9 0.049 12.4 18.9 1.0 1 0 0 1 1 1 0 RIB43A Phage_GPO PF05929.11 KOO29269.1 - 0.17 11.5 4.9 0.18 11.4 4.9 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Fib_alpha PF08702.10 KOO29269.1 - 0.17 12.0 2.7 0.21 11.8 2.7 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF724 PF05266.14 KOO29269.1 - 0.29 10.9 4.3 0.38 10.6 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) MAJIN PF15077.6 KOO29269.1 - 0.69 9.7 6.7 0.7 9.6 6.7 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein NPIP PF06409.11 KOO29269.1 - 0.74 8.8 6.9 0.89 8.6 6.9 1.1 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) CorA PF01544.18 KOO29269.1 - 1.1 8.5 4.3 1.3 8.3 4.3 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Casc1_N PF15927.5 KOO29269.1 - 1.1 8.9 17.9 1.5 8.5 17.9 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus V_ATPase_I PF01496.19 KOO29269.1 - 1.2 6.9 2.8 1.2 6.9 2.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Borrelia_P83 PF05262.11 KOO29269.1 - 1.3 7.5 10.4 1.5 7.2 10.4 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Pinin_SDK_memA PF04696.13 KOO29269.1 - 1.9 8.6 17.5 2.2 8.3 17.5 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region MAS20 PF02064.15 KOO29269.1 - 5.5 7.1 10.3 6.4 6.9 10.3 1.1 1 0 0 1 1 1 0 MAS20 protein import receptor ATP-synt_B PF00430.18 KOO29269.1 - 6.4 6.9 18.9 8 6.6 18.9 1.0 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Presenilin PF01080.17 KOO29269.1 - 8.4 5.0 7.5 8.9 5.0 7.5 1.0 1 0 0 1 1 1 0 Presenilin Metallophos PF00149.28 KOO29270.1 - 3.1e-19 70.3 0.0 6.4e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 KOO29270.1 - 8.2e-13 49.0 0.0 8.2e-13 49.0 0.0 2.6 3 0 0 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 KOO29270.1 - 6.4e-09 36.3 0.4 2.1e-08 34.6 0.4 1.9 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ion_trans PF00520.31 KOO29271.1 - 1.2e-08 34.5 16.2 4.4e-08 32.7 16.2 1.8 1 1 0 1 1 1 1 Ion transport protein LSDAT_euk PF18139.1 KOO29271.1 - 6e-08 32.4 0.0 2.8e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 SLOG in TRPM PKD_channel PF08016.12 KOO29271.1 - 3.7e-07 29.2 8.4 8.6e-07 28.0 8.5 1.5 1 1 0 1 1 1 1 Polycystin cation channel LSDAT_prok PF18171.1 KOO29271.1 - 0.009 15.3 0.0 0.048 12.9 0.0 2.1 1 1 0 1 1 1 1 SLOG in TRPM, prokaryote EF-hand_1 PF00036.32 KOO29272.1 - 4.6e-26 88.4 3.7 2.1e-05 23.8 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO29272.1 - 2.7e-25 86.1 2.2 1.8e-05 24.3 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO29272.1 - 4e-20 72.0 0.2 2.7e-07 30.9 0.2 3.8 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO29272.1 - 6.2e-20 69.7 5.9 0.00013 21.3 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO29272.1 - 2.4e-14 52.9 1.3 0.016 15.0 0.0 4.5 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO29272.1 - 3.7e-05 24.0 0.0 4.5 7.6 0.0 4.4 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO29272.1 - 0.041 14.1 0.0 1.3 9.2 0.0 3.2 3 0 0 3 3 3 0 Dockerin type I domain Methyltransf_18 PF12847.7 KOO29272.1 - 0.12 12.3 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_4 PF12763.7 KOO29272.1 - 0.14 12.1 0.1 15 5.6 0.0 3.1 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand DUF2040 PF09745.9 KOO29272.1 - 4.6 7.3 6.9 2 8.5 0.8 2.7 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) Homeodomain PF00046.29 KOO29275.1 - 3.5e-17 62.0 2.0 4.9e-17 61.5 2.0 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOO29275.1 - 4.2e-06 26.6 0.2 7.5e-06 25.8 0.2 1.4 1 0 0 1 1 1 1 Homeobox KN domain HTH_28 PF13518.6 KOO29275.1 - 0.02 15.0 0.1 0.038 14.1 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain AalphaY_MDB PF04611.12 KOO29276.1 - 0.12 12.4 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Mating type protein A alpha Y mating type dependent binding region Nup88 PF10168.9 KOO29277.1 - 0.3 8.9 11.8 0.3 8.9 11.8 1.2 1 0 0 1 1 1 0 Nuclear pore component BCDHK_Adom3 PF10436.9 KOO29278.1 - 5e-13 49.2 0.2 7.3e-13 48.7 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Kinesin PF00225.23 KOO29280.1 - 9.4e-50 169.4 0.0 1.8e-40 138.9 0.0 2.0 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KOO29280.1 - 6.7e-08 32.6 0.0 1.3e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding DUF1192 PF06698.11 KOO29281.1 - 0.11 12.6 0.1 0.11 12.6 0.1 5.9 5 0 0 5 5 5 0 Protein of unknown function (DUF1192) DUF4573 PF15140.6 KOO29282.1 - 0.0091 15.8 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4573) C2 PF00168.30 KOO29283.1 - 9.1e-27 93.4 0.0 5e-12 46.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain DUF350 PF03994.14 KOO29283.1 - 1.1e-17 63.9 49.9 2.1e-05 24.6 0.6 8.5 9 1 0 9 9 9 6 Domain of Unknown Function (DUF350) LPD39 PF18858.1 KOO29283.1 - 0.043 13.9 0.0 0.073 13.2 0.0 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 39 Cupin_8 PF13621.6 KOO29284.1 - 2.2e-20 73.4 0.1 3.8e-19 69.4 0.1 2.5 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 KOO29284.1 - 3.6e-11 43.5 0.2 5.4e-09 36.5 0.1 3.1 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 KOO29284.1 - 6.7e-05 22.5 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 Cupin superfamily protein EF-hand_6 PF13405.6 KOO29285.1 - 2.4e-13 48.8 5.5 0.00014 21.5 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO29285.1 - 5.2e-13 47.5 8.2 6e-05 22.3 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO29285.1 - 1.3e-10 41.6 5.1 0.00038 20.9 0.3 4.3 2 2 2 5 5 5 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO29285.1 - 1.9e-10 40.4 5.8 8.3e-07 28.8 0.5 3.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO29285.1 - 1.8e-05 24.0 14.1 0.00092 18.6 0.6 3.9 4 0 0 4 4 4 2 EF hand EspA PF03433.13 KOO29285.1 - 0.052 13.4 11.2 2.7 7.8 0.2 4.4 3 2 1 4 4 4 0 EspA-like secreted protein Asp-B-Hydro_N PF05279.11 KOO29285.1 - 1.2 9.2 26.9 0.18 11.8 19.6 2.5 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Kinesin PF00225.23 KOO29289.1 - 2.2e-72 243.8 0.0 2.9e-72 243.4 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO29289.1 - 4.2e-18 65.7 0.0 6.5e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding Vps53_N PF04100.12 KOO29291.1 - 2.7e-99 332.7 2.0 9.1e-99 331.0 2.0 1.9 1 1 0 1 1 1 1 Vps53-like, N-terminal Sec6 PF06046.13 KOO29291.1 - 1.4e-11 43.5 0.4 1.4e-11 43.5 0.4 1.7 2 0 0 2 2 2 1 Exocyst complex component Sec6 Vps54_N PF10475.9 KOO29291.1 - 8.2e-11 41.7 5.3 8.2e-11 41.7 5.3 1.8 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex RINT1_TIP1 PF04437.13 KOO29291.1 - 2.3e-05 23.5 0.0 7.6e-05 21.8 0.0 1.9 1 0 0 1 1 1 1 RINT-1 / TIP-1 family COG2 PF06148.11 KOO29291.1 - 0.0032 17.6 2.2 0.0032 17.6 2.2 2.8 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 FAD_binding_5 PF00941.21 KOO29291.1 - 0.12 12.1 0.9 0.36 10.5 0.1 2.0 2 0 0 2 2 2 0 FAD binding domain in molybdopterin dehydrogenase Spc7 PF08317.11 KOO29291.1 - 0.14 11.0 13.9 0.0099 14.8 7.5 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Sec8_exocyst PF04048.14 KOO29291.1 - 0.21 11.4 4.6 0.53 10.2 2.4 2.9 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain Baculo_PEP_C PF04513.12 KOO29291.1 - 0.41 10.7 4.6 2.1 8.4 3.0 3.1 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG5 PF10392.9 KOO29291.1 - 0.68 10.1 5.8 1.9 8.7 3.1 2.9 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Zw10 PF06248.13 KOO29291.1 - 2.1 6.8 10.9 0.23 10.0 6.3 1.7 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 Sec20 PF03908.13 KOO29291.1 - 6.4 6.8 6.2 1.5 8.8 0.7 2.8 3 0 0 3 3 3 0 Sec20 AbiEi_1 PF09407.10 KOO29294.1 - 0.15 12.4 0.1 0.22 11.8 0.1 1.3 1 0 0 1 1 1 0 AbiEi antitoxin C-terminal domain Pex24p PF06398.11 KOO29294.1 - 0.67 8.9 4.9 0.76 8.7 4.9 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin AAA_12 PF13087.6 KOO29296.1 - 6.5e-59 198.9 0.0 9.2e-59 198.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO29296.1 - 9.5e-24 84.6 2.3 5.2e-20 72.3 0.0 3.1 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 KOO29296.1 - 4e-05 23.5 0.0 0.025 14.3 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 KOO29296.1 - 0.033 14.5 0.0 0.13 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 KOO29297.1 - 9.7e-21 73.7 21.2 0.0098 16.7 0.4 9.7 10 0 0 10 10 10 8 WD domain, G-beta repeat HELP PF03451.14 KOO29297.1 - 9.7e-13 47.8 0.0 2.4e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 HELP motif ANAPC4_WD40 PF12894.7 KOO29297.1 - 0.00049 20.3 0.0 1.5 9.1 0.0 4.5 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 KOO29298.1 - 1.7e-46 158.8 0.0 2.2e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29298.1 - 3.9e-32 111.6 0.0 5.3e-32 111.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Nnf1 PF03980.14 KOO29300.1 - 1.1e-09 38.7 6.0 1.4e-09 38.3 5.5 1.5 1 1 0 1 1 1 1 Nnf1 TMF_TATA_bd PF12325.8 KOO29300.1 - 0.0071 16.6 1.2 0.016 15.5 1.2 1.6 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding BRE1 PF08647.11 KOO29300.1 - 0.025 14.6 2.5 0.048 13.7 2.5 1.5 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF773 PF05600.12 KOO29300.1 - 0.05 12.3 3.8 0.071 11.8 3.8 1.1 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 DUF3664 PF12406.8 KOO29300.1 - 0.1 13.3 0.1 0.17 12.5 0.1 1.3 1 0 0 1 1 1 0 Surface protein bZIP_2 PF07716.15 KOO29300.1 - 0.18 11.9 2.5 0.46 10.6 2.5 1.6 1 0 0 1 1 1 0 Basic region leucine zipper Phytase-like PF13449.6 KOO29301.1 - 0.0069 16.4 0.0 0.0077 16.2 0.0 1.1 1 0 0 1 1 1 1 Esterase-like activity of phytase Cyclin_N PF00134.23 KOO29302.1 - 7.5e-46 155.0 1.9 7.5e-46 155.0 1.9 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOO29302.1 - 1.8e-32 111.9 0.6 3.5e-32 111.0 0.1 1.7 2 0 0 2 2 2 1 Cyclin, C-terminal domain DSPc PF00782.20 KOO29303.1 - 2.4e-10 40.3 0.0 3.8e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOO29303.1 - 0.0074 15.9 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KOO29303.1 - 0.053 13.5 0.1 0.095 12.7 0.1 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family ERCC3_RAD25_C PF16203.5 KOO29305.1 - 1.3e-109 365.2 0.1 1.9e-109 364.6 0.1 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 KOO29305.1 - 3.5e-30 104.8 0.0 6.5e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO29305.1 - 3.5e-15 56.4 0.0 5.6e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOO29305.1 - 1.3e-12 48.0 0.2 3.6e-12 46.6 0.2 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KOO29305.1 - 9.3e-06 24.6 0.0 1.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SWI2_SNF2 PF18766.1 KOO29305.1 - 0.077 12.7 0.0 0.18 11.4 0.0 1.5 1 1 0 1 1 1 0 SWI2/SNF2 ATPase WD40 PF00400.32 KOO29307.1 - 9.6e-18 64.2 1.8 5.4e-10 39.7 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO29307.1 - 2.1e-08 33.5 0.1 0.0045 16.0 0.0 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO29307.1 - 2.3e-06 27.8 0.1 0.054 13.8 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO29307.1 - 1.6e-05 24.7 0.0 0.28 11.2 0.0 2.5 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO29307.1 - 0.011 14.0 0.0 0.014 13.7 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO29307.1 - 0.017 14.5 0.1 1.1 8.5 0.0 2.1 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 KOO29307.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 WD40-like domain Nucleoporin_N PF08801.11 KOO29307.1 - 0.13 11.0 0.1 1.1 7.9 0.0 1.9 1 1 1 2 2 2 0 Nup133 N terminal like rOmpB PF12334.8 KOO29307.1 - 0.15 11.5 1.2 5.5 6.4 0.0 2.1 1 1 0 2 2 2 0 Rickettsia outer membrane protein B PAD_porph PF04371.15 KOO29308.1 - 1.7e-56 191.8 0.0 2.1e-56 191.5 0.0 1.0 1 0 0 1 1 1 1 Porphyromonas-type peptidyl-arginine deiminase E1-E2_ATPase PF00122.20 KOO29309.1 - 1.6e-37 128.8 2.5 6.3e-30 104.0 0.2 2.7 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase PF00702.26 KOO29309.1 - 9.4e-31 107.7 0.7 2.2e-30 106.5 0.2 2.0 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase TPR_21 PF09976.9 KOO29309.1 - 1.1 8.9 7.7 9.3 5.9 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain Ank_4 PF13637.6 KOO29310.1 - 4.7e-17 62.1 0.0 6.1e-09 36.2 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO29310.1 - 1.3e-15 57.7 0.1 1.3e-07 32.1 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO29310.1 - 3.8e-10 39.7 0.0 0.001 19.4 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KOO29310.1 - 2.5e-08 33.6 0.0 0.0067 16.9 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOO29310.1 - 3.7e-08 33.5 0.0 3.7e-05 23.9 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) MBOAT PF03062.19 KOO29312.1 - 2.1e-26 93.1 12.9 3.1e-26 92.5 12.9 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 KOO29312.1 - 0.056 13.7 5.5 0.14 12.5 5.5 1.7 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family SMC_N PF02463.19 KOO29313.1 - 0.083 12.3 0.0 0.095 12.1 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain EGF_2 PF07974.13 KOO29314.1 - 6.5e-68 224.7 394.8 4.4e-05 23.8 13.0 20.4 20 0 0 20 20 20 20 EGF-like domain EGF_Tenascin PF18720.1 KOO29314.1 - 1.2e-38 130.5 323.5 9.1e-07 28.8 10.1 20.9 21 0 0 21 21 21 18 Tenascin EGF domain EGF PF00008.27 KOO29314.1 - 1e-11 44.9 317.5 0.021 15.1 8.0 20.8 20 0 0 20 20 20 16 EGF-like domain hEGF PF12661.7 KOO29314.1 - 1.1e-09 38.5 273.0 0.021 15.5 6.9 21.5 20 0 0 20 20 20 14 Human growth factor-like EGF Rdx PF10262.9 KOO29315.1 - 0.0079 16.4 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 Rdx family DivIC PF04977.15 KOO29315.1 - 0.015 15.1 0.4 0.064 13.0 0.4 2.1 1 0 0 1 1 1 0 Septum formation initiator Chloroa_b-bind PF00504.21 KOO29316.1 - 6.1e-33 114.6 0.1 8.2e-33 114.2 0.1 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein ART PF01129.18 KOO29317.1 - 6.5e-10 38.7 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO29317.1 - 8.2e-08 31.8 0.0 2.4e-07 30.3 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme TrmB PF01978.19 KOO29317.1 - 0.00034 20.5 0.0 0.0006 19.7 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB CNOT1_HEAT PF16418.5 KOO29318.1 - 0.022 14.8 0.0 0.094 12.8 0.0 2.1 1 1 1 2 2 2 0 CCR4-NOT transcription complex subunit 1 HEAT repeat Chlorophyllase PF07224.11 KOO29318.1 - 0.2 10.6 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Rubredoxin PF00301.20 KOO29320.1 - 1.9e-05 24.6 2.1 0.00099 19.1 2.1 2.5 1 1 0 1 1 1 1 Rubredoxin DUF1610 PF07754.11 KOO29320.1 - 0.016 15.1 5.1 0.025 14.6 1.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1610) Zn-ribbon_8 PF09723.10 KOO29320.1 - 0.017 15.2 2.6 0.047 13.8 2.6 1.8 1 0 0 1 1 1 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 KOO29320.1 - 0.094 12.3 2.0 5.4 6.6 0.2 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding zf-ribbon_3 PF13248.6 KOO29320.1 - 0.29 10.6 3.2 3.6 7.1 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon domain RNA_POL_M_15KD PF02150.16 KOO29320.1 - 0.56 10.1 1.8 2.6 8.0 0.2 2.0 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit Phage_GP20 PF06810.11 KOO29320.1 - 0.71 9.7 6.5 1.5 8.6 6.5 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 zf-H2C2_2 PF13465.6 KOO29320.1 - 0.95 10.0 2.4 35 5.1 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double domain TFIIS_C PF01096.18 KOO29320.1 - 1.6 8.7 6.4 10 6.1 0.2 3.3 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) Zn_Tnp_IS1595 PF12760.7 KOO29320.1 - 3.9 7.5 6.4 3 7.9 0.0 3.1 3 0 0 3 3 3 0 Transposase zinc-ribbon domain zf-Mss51 PF13824.6 KOO29320.1 - 7.8 6.7 5.5 17 5.6 0.4 2.4 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Vta1 PF04652.16 KOO29321.1 - 3.1e-09 36.9 0.0 5.6e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 Vta1 like UPF0176_N PF17773.1 KOO29322.1 - 1.6e-18 66.8 0.0 3.4e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese PF00581.20 KOO29322.1 - 0.038 14.5 0.0 0.54 10.8 0.0 2.6 2 1 0 2 2 2 0 Rhodanese-like domain MDMPI_N PF11716.8 KOO29322.1 - 0.044 14.5 1.2 0.044 14.5 1.2 3.2 2 1 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain ubiquitin PF00240.23 KOO29322.1 - 0.19 11.5 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family DUF2870 PF11069.8 KOO29323.1 - 0.00016 22.0 0.0 0.00035 20.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) pPIWI_RE_Y PF18156.1 KOO29323.1 - 0.056 13.9 0.5 0.12 12.8 0.1 1.6 2 0 0 2 2 2 0 pPIWI_RE three-gene island domain Y ubiquitin PF00240.23 KOO29323.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family Peptidase_S49 PF01343.18 KOO29324.1 - 1.2e-31 109.7 0.0 2e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S49 Peptidase_S49_N PF08496.10 KOO29324.1 - 1.3e-14 54.6 0.1 7.5e-14 52.1 0.1 2.0 1 1 0 1 1 1 1 Peptidase family S49 N-terminal SDH_sah PF01972.16 KOO29324.1 - 0.0022 17.0 0.2 0.0034 16.4 0.2 1.2 1 0 0 1 1 1 1 Serine dehydrogenase proteinase CLP_protease PF00574.23 KOO29324.1 - 0.036 13.9 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Clp protease Pkinase PF00069.25 KOO29325.1 - 3.3e-21 75.8 0.0 3.6e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29325.1 - 1.5e-09 37.6 0.0 1.6e-09 37.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO29325.1 - 0.031 13.6 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 KOO29325.1 - 0.15 11.1 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 HrpF PF06266.12 KOO29325.1 - 0.19 12.1 0.0 0.25 11.7 0.0 1.1 1 0 0 1 1 1 0 HrpF protein Pkinase_fungal PF17667.1 KOO29325.1 - 0.22 10.2 0.0 0.22 10.2 0.0 1.0 1 0 0 1 1 1 0 Fungal protein kinase Metallophos PF00149.28 KOO29326.1 - 9.5e-19 68.7 0.0 2e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1118 PF06549.12 KOO29326.1 - 2.4e-07 31.0 4.5 4.9e-07 30.1 4.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1118) Band_7 PF01145.25 KOO29328.1 - 7.2e-26 91.3 2.6 1.6e-25 90.1 2.6 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.8 KOO29328.1 - 0.16 12.2 0.9 0.27 11.4 0.9 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 SHR3_chaperone PF08229.11 KOO29329.1 - 0.053 12.5 0.0 0.072 12.1 0.0 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 EF-hand_1 PF00036.32 KOO29330.1 - 4.9e-23 78.9 1.1 4.6e-05 22.7 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO29330.1 - 2.2e-21 73.9 2.1 5.8e-05 22.7 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO29330.1 - 2.8e-18 66.1 5.4 7.7e-09 35.9 1.1 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO29330.1 - 5.7e-12 44.5 8.5 0.0011 18.3 0.1 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO29330.1 - 1.3e-08 34.5 6.7 0.00031 20.5 0.1 3.7 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 KOO29330.1 - 0.0035 17.3 4.8 0.87 9.6 0.7 3.1 2 2 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO29330.1 - 0.0042 16.9 0.5 1.8 8.5 0.0 3.8 4 0 0 4 4 4 1 EF hand EF-hand_11 PF08976.11 KOO29330.1 - 0.0052 17.6 0.0 1.4 9.9 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain Cbl_N2 PF02761.14 KOO29330.1 - 0.014 16.1 0.4 4.9 7.9 0.1 3.1 3 0 0 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain SlyX PF04102.12 KOO29331.1 - 0.023 15.3 0.0 0.026 15.1 0.0 1.1 1 0 0 1 1 1 0 SlyX NPV_P10 PF05531.12 KOO29331.1 - 0.072 13.6 0.0 0.094 13.2 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 KOO29331.1 - 0.093 13.0 0.0 0.13 12.4 0.0 1.3 1 1 0 1 1 1 0 Haemolysin XhlA DUF1664 PF07889.12 KOO29331.1 - 0.1 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) MnmE_helical PF12631.7 KOO29331.1 - 0.15 12.2 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 MnmE helical domain AAA PF00004.29 KOO29333.1 - 4.4e-24 85.4 0.0 2.1e-22 80.0 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SAM_MT PF04445.13 KOO29333.1 - 4.2e-05 23.1 0.1 0.00013 21.5 0.0 1.8 2 0 0 2 2 2 1 Putative SAM-dependent methyltransferase AAA_5 PF07728.14 KOO29333.1 - 0.00026 21.0 0.0 0.00062 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 KOO29333.1 - 0.091 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_25 PF13481.6 KOO29333.1 - 0.11 12.0 5.1 0.23 11.0 0.3 3.3 3 1 1 4 4 4 0 AAA domain AAA_16 PF13191.6 KOO29333.1 - 0.2 12.0 0.1 0.2 12.0 0.1 3.9 3 2 1 4 4 4 0 AAA ATPase domain RNA_helicase PF00910.22 KOO29333.1 - 0.23 11.9 0.0 0.38 11.2 0.0 1.3 1 0 0 1 1 1 0 RNA helicase WD40 PF00400.32 KOO29336.1 - 8.3e-10 39.1 21.9 0.00065 20.5 1.6 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat PQQ_3 PF13570.6 KOO29336.1 - 0.02 15.4 0.8 0.54 10.8 0.0 3.3 3 0 0 3 3 3 0 PQQ-like domain WD40_like PF17005.5 KOO29336.1 - 0.24 10.7 0.0 0.69 9.2 0.0 1.7 1 1 1 2 2 2 0 WD40-like domain Mg_trans_NIPA PF05653.14 KOO29337.1 - 1.8e-17 63.4 12.2 3.4e-17 62.5 12.2 1.5 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KOO29337.1 - 0.024 14.8 1.8 0.024 14.8 1.8 3.1 2 1 0 3 3 3 0 EamA-like transporter family TMEM234 PF10639.9 KOO29337.1 - 0.076 13.1 0.4 0.15 12.1 0.4 1.5 1 0 0 1 1 1 0 Putative transmembrane family 234 TPT PF03151.16 KOO29339.1 - 1.1e-13 51.2 24.8 1.3e-13 50.9 24.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO29339.1 - 4.4e-08 33.4 31.2 1.1e-05 25.6 7.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family Glyco_hydro81C PF17652.1 KOO29340.1 - 7.6e-84 281.9 0.0 1.1e-83 281.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 KOO29340.1 - 5.3e-37 127.7 0.0 1.2e-33 116.7 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 81 N-terminal domain SprT-like PF10263.9 KOO29341.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 SprT-like family Aa_trans PF01490.18 KOO29342.1 - 1.1e-30 106.6 14.8 1.5e-30 106.2 14.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Peptidase_C2 PF00648.21 KOO29343.1 - 7.4e-53 179.5 0.0 1.2e-52 178.8 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Acetyltransf_3 PF13302.7 KOO29343.1 - 3.6e-18 66.6 0.1 8.1e-18 65.4 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain EamA PF00892.20 KOO29343.1 - 1.7e-07 31.5 46.4 1e-05 25.7 17.3 2.3 2 0 0 2 2 2 2 EamA-like transporter family Acetyltransf_1 PF00583.25 KOO29343.1 - 4.7e-06 26.8 0.1 9.2e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family PUNUT PF16913.5 KOO29343.1 - 0.00066 19.0 6.2 0.0015 17.9 6.2 1.5 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport PX PF00787.24 KOO29344.1 - 1.7e-32 111.8 0.0 4.4e-15 55.7 0.0 2.4 2 0 0 2 2 2 2 PX domain PKcGMP_CC PF16808.5 KOO29344.1 - 0.19 11.6 0.1 0.19 11.6 0.1 3.9 6 0 0 6 6 6 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Ephrin_rec_like PF07699.13 KOO29345.1 - 1.5e-30 104.7 65.1 7.4e-08 32.0 4.3 7.3 2 2 5 7 7 7 7 Putative ephrin-receptor like NCD3G PF07562.14 KOO29345.1 - 4.2e-10 39.4 42.1 0.04 13.9 3.0 7.3 4 1 3 7 7 7 7 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 KOO29345.1 - 0.64 10.5 0.0 0.64 10.5 0.0 8.9 4 3 5 9 9 9 0 TNFR/NGFR cysteine-rich region KH_7 PF17214.3 KOO29346.1 - 0.19 11.7 0.0 0.34 10.9 0.0 1.3 1 0 0 1 1 1 0 KH domain Cnd2 PF05786.14 KOO29346.1 - 0.4 9.3 2.8 0.55 8.8 2.8 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 SDA1 PF05285.12 KOO29346.1 - 0.84 9.0 4.2 1.2 8.5 4.2 1.1 1 0 0 1 1 1 0 SDA1 Abhydrolase_2 PF02230.16 KOO29347.1 - 7.1e-18 65.2 0.0 1e-17 64.7 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase PIH1_CS PF18201.1 KOO29347.1 - 4.5e-10 39.8 0.0 7.9e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 PIH1 CS-like domain DLH PF01738.18 KOO29347.1 - 1.7e-08 34.3 0.0 2.7e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 KOO29347.1 - 0.00012 21.5 0.4 0.09 12.0 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOO29347.1 - 0.0016 17.9 0.1 0.027 14.0 0.0 2.1 1 1 1 2 2 2 1 Prolyl oligopeptidase family CS PF04969.16 KOO29347.1 - 0.033 15.2 0.0 0.053 14.6 0.0 1.3 1 0 0 1 1 1 0 CS domain Esterase_phd PF10503.9 KOO29347.1 - 0.14 11.7 4.9 0.11 12.0 0.8 2.4 2 1 0 2 2 2 0 Esterase PHB depolymerase Abhydrolase_3 PF07859.13 KOO29347.1 - 1.3 8.9 4.1 1.9 8.3 0.1 2.6 2 1 1 3 3 3 0 alpha/beta hydrolase fold Arf PF00025.21 KOO29348.1 - 1.1e-47 161.8 0.0 1.3e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KOO29348.1 - 8.8e-11 41.6 0.0 2.1e-07 30.5 0.0 2.4 2 1 0 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 KOO29348.1 - 2.7e-09 36.7 0.0 4e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KOO29348.1 - 1.1e-08 35.3 0.0 2.1e-08 34.4 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO29348.1 - 7.5e-08 32.1 0.0 1.1e-07 31.6 0.0 1.3 1 1 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KOO29348.1 - 6.7e-07 28.9 0.0 7.8e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO29348.1 - 1.6e-05 24.9 0.0 2.6e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOO29348.1 - 0.0073 15.9 0.0 0.015 14.8 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KOO29348.1 - 0.028 14.8 0.0 2 8.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Queuosine_synth PF02547.15 KOO29349.1 - 8.2e-90 301.2 0.0 3.6e-60 203.8 0.0 2.4 2 0 0 2 2 2 2 Queuosine biosynthesis protein QueH PF02677.14 KOO29349.1 - 6.6e-62 208.7 2.1 1.1e-61 207.9 2.1 1.4 1 0 0 1 1 1 1 Epoxyqueuosine reductase QueH U-box PF04564.15 KOO29350.1 - 4e-13 49.4 0.0 8.3e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO29350.1 - 5.2e-08 33.3 15.8 9.5e-07 29.3 1.0 4.4 4 1 0 4 4 4 2 Sel1 repeat zf-NOSIP PF15906.5 KOO29350.1 - 0.0003 20.9 0.0 0.0011 19.1 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO29350.1 - 0.0019 17.9 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit MKLP1_Arf_bdg PF16540.5 KOO29350.1 - 0.077 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Arf6-interacting domain of mitotic kinesin-like protein 1 U-box PF04564.15 KOO29351.1 - 3.2e-12 46.4 0.0 5.8e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO29351.1 - 1.1e-11 45.0 11.8 7.9e-08 32.7 0.5 3.6 3 0 0 3 3 3 2 Sel1 repeat zf-NOSIP PF15906.5 KOO29351.1 - 0.00047 20.2 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO29351.1 - 0.00088 19.0 0.1 0.0041 16.9 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Sigma70_r3 PF04539.16 KOO29351.1 - 0.053 13.6 0.1 0.053 13.6 0.1 2.1 2 0 0 2 2 2 0 Sigma-70 region 3 TPR_6 PF13174.6 KOO29351.1 - 0.084 13.5 2.4 1.1 10.0 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3498 PF12004.8 KOO29351.1 - 0.16 11.1 0.1 0.2 10.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) DUF1269 PF06897.12 KOO29353.1 - 0.0056 16.9 1.6 0.0056 16.9 1.6 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1269) DUF1824 PF08854.10 KOO29353.1 - 0.17 11.8 0.9 1.8 8.5 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1824) NPL PF17800.1 KOO29354.1 - 5.4e-05 23.7 0.0 0.00011 22.8 0.0 1.5 1 0 0 1 1 1 1 Nucleoplasmin-like domain ABC_membrane PF00664.23 KOO29354.1 - 0.00018 21.3 3.5 0.00061 19.5 3.5 1.7 1 1 0 1 1 1 1 ABC transporter transmembrane region Phage_holin_2_4 PF16082.5 KOO29355.1 - 1.5 8.6 5.7 3.4 7.5 5.7 1.6 1 1 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Pkinase PF00069.25 KOO29356.1 - 9.7e-18 64.5 0.0 2.4e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29356.1 - 6.8e-11 41.9 0.1 3.6e-10 39.6 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase ART PF01129.18 KOO29356.1 - 0.013 14.9 0.0 0.013 14.9 0.0 2.4 3 1 0 3 3 3 0 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO29356.1 - 0.072 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme DUF2975 PF11188.8 KOO29359.1 - 0.019 14.8 1.7 0.038 13.9 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) RR_TM4-6 PF06459.12 KOO29359.1 - 6.5 6.5 11.3 9.5 6.0 11.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sel1 PF08238.12 KOO29360.1 - 1.1e-12 48.2 4.4 1e-05 26.0 0.3 3.7 3 0 0 3 3 3 3 Sel1 repeat U-box PF04564.15 KOO29360.1 - 5.5e-12 45.7 0.0 1.3e-11 44.5 0.0 1.6 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 KOO29360.1 - 0.00044 20.0 0.2 0.0016 18.2 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO29360.1 - 0.00083 19.4 0.0 0.0033 17.5 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein CZB PF13682.6 KOO29360.1 - 0.013 15.9 0.5 0.053 14.0 0.5 2.0 2 0 0 2 2 2 0 Chemoreceptor zinc-binding domain Hydrophobin_2 PF06766.11 KOO29360.1 - 0.022 14.7 0.6 0.041 13.8 0.6 1.4 1 0 0 1 1 1 0 Fungal hydrophobin Sigma70_r3 PF04539.16 KOO29360.1 - 0.025 14.7 0.1 0.025 14.7 0.1 2.0 2 0 0 2 2 2 0 Sigma-70 region 3 DUF469 PF04320.14 KOO29360.1 - 0.082 13.8 0.0 3.4 8.6 0.0 2.5 2 0 0 2 2 2 0 Protein with unknown function (DUF469) TPR_19 PF14559.6 KOO29361.1 - 0.076 13.5 0.3 1.3 9.6 0.1 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat APG12 PF04110.13 KOO29362.1 - 4.1e-24 84.8 0.0 4.7e-24 84.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 KOO29362.1 - 0.00078 19.6 0.0 0.00083 19.5 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Amidohydro_1 PF01979.20 KOO29363.1 - 5.2e-37 127.9 0.0 5.2e-14 52.3 0.0 3.2 2 1 1 3 3 3 3 Amidohydrolase family Pribosyltran PF00156.27 KOO29363.1 - 1.5e-08 34.4 0.2 7.1e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 Phosphoribosyl transferase domain Amidohydro_3 PF07969.11 KOO29363.1 - 3.5e-05 23.5 2.2 0.27 10.7 0.2 3.0 2 2 0 2 2 2 2 Amidohydrolase family UPRTase PF14681.6 KOO29363.1 - 0.0021 17.5 0.0 0.0036 16.8 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Xan_ur_permease PF00860.20 KOO29364.1 - 3.4e-33 114.9 33.8 1.6e-17 63.3 18.7 2.4 2 1 0 2 2 2 2 Permease family Phage_holin_2_3 PF16080.5 KOO29364.1 - 1.5 8.6 4.7 3.9 7.3 0.9 3.0 2 0 0 2 2 2 0 Bacteriophage holin family HP1 DoxX_3 PF13781.6 KOO29365.1 - 0.96 10.1 10.3 0.061 14.0 3.2 2.4 2 0 0 2 2 2 0 DoxX-like family Response_reg PF00072.24 KOO29367.1 - 0.00024 21.3 0.0 0.0031 17.7 0.0 2.7 3 0 0 3 3 3 1 Response regulator receiver domain HMG_box PF00505.19 KOO29370.1 - 9.3e-15 54.8 0.0 1.2e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO29370.1 - 1.7e-07 31.7 0.0 2e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 HMG-box domain Exostosin PF03016.15 KOO29371.1 - 3e-31 108.8 0.0 5.1e-31 108.0 0.0 1.3 1 1 0 1 1 1 1 Exostosin family Sulfate_transp PF00916.20 KOO29373.1 - 5.2e-32 111.0 34.6 1.3e-19 70.3 13.7 3.2 1 1 1 2 2 2 2 Sulfate permease family zf-C2H2_aberr PF17017.5 KOO29374.1 - 0.12 12.5 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Aberrant zinc-finger zf-C2H2_4 PF13894.6 KOO29374.1 - 0.38 11.7 2.1 0.74 10.8 2.1 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger PAN_1 PF00024.26 KOO29375.1 - 0.0067 16.4 0.5 0.021 14.8 0.5 1.8 1 0 0 1 1 1 1 PAN domain E1_dh PF00676.20 KOO29376.1 - 4.9e-47 160.3 0.1 9.5e-47 159.4 0.1 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_C PF02780.20 KOO29376.1 - 9.8e-24 83.6 0.1 2.4e-23 82.4 0.1 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 KOO29376.1 - 2.3e-14 53.5 0.3 7.6e-14 51.8 0.0 1.9 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain TPP_enzyme_C PF02775.21 KOO29376.1 - 7.7e-05 22.5 0.7 0.00051 19.9 0.0 2.7 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFOR_II PF17147.4 KOO29376.1 - 0.0037 17.5 0.0 0.033 14.5 0.0 2.4 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II DXP_synthase_N PF13292.6 KOO29376.1 - 0.0079 15.4 0.0 0.018 14.3 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase PhoLip_ATPase_C PF16212.5 KOO29377.1 - 2.2e-53 181.6 22.4 2.2e-53 181.6 22.4 2.5 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 KOO29377.1 - 2.6e-11 43.4 0.0 3.5e-10 39.8 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOO29377.1 - 3e-09 37.5 7.5 4.7e-05 23.8 1.3 3.3 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase PhoLip_ATPase_N PF16209.5 KOO29377.1 - 3.7e-09 36.2 1.8 1.4e-08 34.3 1.8 2.0 1 1 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 KOO29377.1 - 4.8e-05 22.9 0.0 0.00024 20.7 0.0 2.3 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KOO29377.1 - 0.0013 18.6 0.1 0.0025 17.6 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOO29379.1 - 9.9e-09 35.5 0.0 3.3e-08 33.8 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO29379.1 - 2.4e-08 34.5 0.0 4.9e-08 33.5 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO29379.1 - 1.4e-06 28.2 0.0 2.8e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Nucleotid_trans PF03407.16 KOO29380.1 - 6.7e-24 85.0 0.0 9.9e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF5340 PF17275.2 KOO29381.1 - 0.084 13.0 0.1 0.22 11.6 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5340) Kinesin PF00225.23 KOO29382.1 - 7.3e-107 357.1 2.8 9.5e-107 356.8 0.2 2.3 3 0 0 3 3 3 1 Kinesin motor domain PCO_ADO PF07847.12 KOO29382.1 - 2.7e-35 121.7 0.0 8.2e-34 116.8 0.0 2.5 1 1 0 1 1 1 1 PCO_ADO Microtub_bd PF16796.5 KOO29382.1 - 5e-23 81.7 0.0 1.9e-22 79.8 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding Rhodanese PF00581.20 KOO29382.1 - 3.7e-11 43.5 0.0 2.4e-10 40.9 0.0 2.4 2 0 0 2 2 2 1 Rhodanese-like domain T2SSE PF00437.20 KOO29382.1 - 0.004 16.3 0.0 0.15 11.1 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 KOO29382.1 - 0.0045 17.4 11.3 0.0087 16.5 0.0 4.4 4 1 0 4 4 3 1 AAA ATPase domain Zeta_toxin PF06414.12 KOO29382.1 - 0.0047 16.2 0.1 0.07 12.4 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin CDO_I PF05995.12 KOO29382.1 - 0.0075 15.6 0.0 0.022 14.1 0.0 1.7 1 0 0 1 1 1 1 Cysteine dioxygenase type I AAA_22 PF13401.6 KOO29382.1 - 0.013 15.7 0.3 2.5 8.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 KOO29382.1 - 0.069 12.6 0.0 0.29 10.6 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain ResIII PF04851.15 KOO29382.1 - 0.097 12.7 0.1 11 6.0 0.2 2.9 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 KOO29382.1 - 0.23 12.0 1.3 0.68 10.5 0.0 2.5 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 KOO29382.1 - 0.43 10.7 3.2 1.3 9.2 0.0 3.2 3 0 0 3 3 2 0 AAA domain AAA_19 PF13245.6 KOO29382.1 - 0.67 10.3 3.2 2.2 8.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 KOO29382.1 - 1.4 9.4 0.0 1.4 9.4 0.0 4.5 3 1 1 4 4 3 0 AAA domain Kelch_5 PF13854.6 KOO29383.1 - 4.1e-23 80.9 7.6 0.00024 21.0 0.1 6.7 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KOO29383.1 - 1.7e-20 72.8 6.1 0.0015 18.5 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain ACBP PF00887.19 KOO29383.1 - 5.6e-18 64.9 0.3 1e-17 64.1 0.3 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein Kelch_3 PF13415.6 KOO29383.1 - 2.1e-14 53.4 14.7 2.1e-05 24.7 0.0 6.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KOO29383.1 - 2.6e-14 52.5 10.4 0.0016 18.0 0.1 6.5 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KOO29383.1 - 6.7e-14 51.2 4.7 3.3e-05 23.7 0.0 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 KOO29383.1 - 2e-12 46.9 3.9 0.004 17.4 0.0 6.3 6 0 0 6 6 6 3 Kelch motif Cyto_heme_lyase PF01265.17 KOO29384.1 - 6.9e-29 101.3 1.9 2.4e-27 96.3 1.9 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase Hexapep PF00132.24 KOO29385.1 - 4.3e-13 48.4 2.4 0.0048 16.6 0.0 4.4 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 KOO29385.1 - 0.037 13.0 0.1 0.078 11.9 0.0 1.4 1 1 0 1 1 1 0 L-fucokinase Beta_helix PF13229.6 KOO29385.1 - 0.055 13.3 0.2 0.075 12.9 0.2 1.2 1 0 0 1 1 1 0 Right handed beta helix region Hexapep_2 PF14602.6 KOO29385.1 - 0.83 9.5 7.7 4.2 7.2 2.5 4.0 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase Smr PF01713.21 KOO29386.1 - 7.7e-07 29.4 0.0 1.3e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Smr domain PPR PF01535.20 KOO29386.1 - 0.00019 21.4 0.1 0.04 14.2 0.0 2.8 3 0 0 3 3 3 1 PPR repeat TPR_14 PF13428.6 KOO29386.1 - 0.004 17.9 7.2 0.78 10.7 0.2 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO29386.1 - 0.006 17.1 0.4 0.006 17.1 0.4 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO29386.1 - 0.0064 16.4 1.9 2.2 8.5 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOO29386.1 - 0.011 16.4 2.7 0.74 10.6 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KOO29386.1 - 0.031 13.9 0.2 0.57 9.8 0.1 2.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_16 PF13432.6 KOO29386.1 - 5.8 7.6 9.4 0.78 10.4 4.4 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat GMC_oxred_N PF00732.19 KOO29387.1 - 6e-45 153.9 0.2 3e-42 145.0 0.2 3.0 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOO29387.1 - 1.8e-32 112.9 0.2 3.5e-32 111.9 0.2 1.5 1 0 0 1 1 1 1 GMC oxidoreductase CBM_11 PF03425.13 KOO29387.1 - 0.004 17.0 0.0 0.0065 16.4 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain (family 11) FPN1 PF06963.12 KOO29389.1 - 5.5e-55 186.7 12.8 7.8e-27 93.9 9.6 2.5 1 1 1 2 2 2 2 Ferroportin1 (FPN1) PQ-loop PF04193.14 KOO29389.1 - 3.1e-31 106.9 6.7 5.9e-17 61.2 4.3 2.9 2 0 0 2 2 2 2 PQ loop repeat CDH PF02611.15 KOO29389.1 - 0.36 10.4 1.2 0.57 9.8 1.2 1.2 1 0 0 1 1 1 0 CDP-diacylglycerol pyrophosphatase Glyco_hydro_2_C PF02836.17 KOO29391.1 - 5.9e-87 291.6 0.0 1.9e-86 289.9 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 KOO29391.1 - 4.5e-40 137.8 0.0 6.8e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 KOO29391.1 - 4.8e-24 85.2 0.0 1.7e-16 60.6 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 KOO29391.1 - 2.4e-07 31.4 0.0 8.3e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 DUF4981 PF16353.5 KOO29391.1 - 3.1e-05 24.4 0.0 0.00011 22.6 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function(DUF4981) Tfb4 PF03850.14 KOO29392.1 - 5.5e-34 117.9 6.7 6.5e-34 117.7 0.1 2.3 2 0 0 2 2 2 2 Transcription factor Tfb4 Ank_5 PF13857.6 KOO29393.1 - 6.9e-07 29.4 0.0 1.2e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO29393.1 - 2e-05 25.1 0.0 3.9e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO29393.1 - 0.0023 18.4 0.1 0.0099 16.4 0.1 2.0 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO29393.1 - 0.012 16.1 0.5 5.6 7.9 0.1 2.7 2 0 0 2 2 2 0 Ankyrin repeat Ank PF00023.30 KOO29393.1 - 0.15 12.6 0.1 20 5.8 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 KOO29394.1 - 1.5e-25 89.5 3.2 3.4e-09 37.2 0.4 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO29394.1 - 1.4e-20 73.4 0.2 1.6e-06 28.6 0.0 3.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO29394.1 - 5.2e-19 68.1 2.0 3e-07 30.6 0.3 4.0 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO29394.1 - 1e-17 63.7 2.1 4.4e-05 23.7 0.5 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 KOO29394.1 - 1.8e-15 55.4 0.1 0.002 18.4 0.1 6.7 7 0 0 7 7 7 3 Ankyrin repeat SHE3 PF17078.5 KOO29394.1 - 3.2 7.4 7.3 0.22 11.2 2.2 1.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 NOA36 PF06524.12 KOO29395.1 - 0.0019 17.6 13.9 0.0034 16.8 13.9 1.3 1 0 0 1 1 1 1 NOA36 protein SDA1 PF05285.12 KOO29395.1 - 0.035 13.6 13.7 0.04 13.3 13.7 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 KOO29395.1 - 0.04 12.1 12.4 0.044 12.0 12.4 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 KOO29395.1 - 0.17 11.2 13.3 0.23 10.7 13.3 1.2 1 0 0 1 1 1 0 BUD22 DUF2457 PF10446.9 KOO29395.1 - 0.22 10.6 19.8 0.32 10.1 19.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 KOO29395.1 - 0.75 8.0 9.9 0.81 7.9 9.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 KOO29395.1 - 2.4 7.7 14.7 1.1 8.8 12.2 1.6 2 0 0 2 2 2 0 PPP4R2 RRN3 PF05327.11 KOO29395.1 - 2.6 6.5 6.0 2.9 6.3 6.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SURF2 PF05477.11 KOO29395.1 - 9 5.9 10.8 4.2 7.0 8.5 1.5 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) YqaJ PF09588.10 KOO29396.1 - 1.4e-20 73.9 0.0 2e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain DEAD PF00270.29 KOO29398.1 - 4.2e-29 101.6 0.0 5.6e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO29398.1 - 0.00025 21.1 0.0 0.00034 20.7 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ATP-synt_Eps PF04627.13 KOO29399.1 - 1.5 8.9 4.4 1.3 9.1 0.5 2.5 2 1 1 3 3 3 0 Mitochondrial ATP synthase epsilon chain ShK PF01549.24 KOO29400.1 - 0.47 11.0 12.5 22 5.7 0.1 4.4 4 1 0 4 4 4 0 ShK domain-like Chromo PF00385.24 KOO29401.1 - 2.2e-05 24.3 0.0 0.00011 22.0 0.0 2.0 2 1 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DUF3653 PF12375.8 KOO29401.1 - 0.031 14.4 0.9 1.1 9.4 0.2 2.6 1 1 1 2 2 2 0 Phage protein Mtf2_C PF14061.6 KOO29401.1 - 0.16 12.2 0.5 0.4 10.9 0.0 1.9 2 0 0 2 2 2 0 Polycomb-like MTF2 factor 2 DUF382 PF04037.13 KOO29402.1 - 1.2e-43 148.3 8.3 6e-28 97.5 0.0 2.7 2 1 1 3 3 3 2 Domain of unknown function (DUF382) PSP PF04046.16 KOO29402.1 - 4.6e-19 68.0 3.7 1.2e-18 66.7 3.7 1.8 1 0 0 1 1 1 1 PSP Cation_efflux PF01545.21 KOO29403.1 - 2.3e-29 102.5 13.6 3e-29 102.2 13.6 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 KOO29403.1 - 1.4e-09 37.9 0.4 2.6e-09 37.1 0.4 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Holin_SPP1 PF04688.13 KOO29403.1 - 0.037 14.2 0.6 0.12 12.5 0.6 1.9 1 0 0 1 1 1 0 SPP1 phage holin Kelch_1 PF01344.25 KOO29404.1 - 2.6e-92 302.2 5.3 1.1e-18 66.6 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KOO29404.1 - 7.2e-52 172.1 0.0 1.2e-10 41.2 0.0 6.4 1 1 5 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KOO29404.1 - 6.3e-49 162.2 0.0 1.1e-07 31.5 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KOO29404.1 - 6.2e-41 138.0 9.3 8e-10 38.8 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO29404.1 - 7.6e-33 112.3 0.0 9.2e-06 25.6 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO29404.1 - 2.3e-23 81.7 7.9 0.00012 22.0 0.0 6.7 7 0 0 7 7 7 5 Kelch motif BACK PF07707.15 KOO29404.1 - 2.2e-18 66.2 0.1 4.2e-18 65.3 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 KOO29404.1 - 5.8e-14 52.3 0.0 1.2e-13 51.2 0.0 1.5 2 0 0 2 2 1 1 BTB/POZ domain DUF1668 PF07893.13 KOO29404.1 - 8.9e-06 25.3 1.6 0.34 10.2 0.0 4.8 1 1 5 6 6 6 1 Protein of unknown function (DUF1668) DUF134 PF02001.16 KOO29404.1 - 0.00028 21.4 0.3 44 4.7 0.0 5.5 6 0 0 6 6 5 0 Protein of unknown function DUF134 DciA PF05258.12 KOO29404.1 - 0.0016 18.8 0.0 2.7 8.5 0.0 4.0 4 1 1 5 5 5 1 Dna[CI] antecedent, DciA Peptidase_S9_N PF02897.15 KOO29404.1 - 0.11 11.3 0.0 0.22 10.3 0.0 1.4 2 0 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Cupin_8 PF13621.6 KOO29405.1 - 1.1e-09 38.4 0.0 1.5e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO29405.1 - 1.2e-05 25.0 0.1 4e-05 23.2 0.1 1.7 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 KOO29405.1 - 1.8e-05 25.1 0.0 4.2e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cu-oxidase_2 PF07731.14 KOO29405.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Multicopper oxidase Gly-zipper_Omp PF13488.6 KOO29405.1 - 1.2 9.2 12.7 3.5 7.7 12.7 1.9 1 0 0 1 1 1 0 Glycine zipper TPR_2 PF07719.17 KOO29406.1 - 5.9e-06 26.0 7.6 0.34 11.1 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO29406.1 - 0.00024 20.8 3.8 1.9 8.4 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO29406.1 - 0.0012 19.3 6.7 0.0025 18.3 0.3 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO29406.1 - 0.016 15.8 0.8 0.016 15.8 0.8 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO29406.1 - 0.044 14.2 1.6 0.4 11.2 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO29406.1 - 0.056 13.7 1.3 15 6.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO29406.1 - 0.3 12.0 0.4 0.3 12.0 0.4 5.3 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO29406.1 - 3.9 7.8 10.3 10 6.5 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO29406.1 - 7 7.6 26.7 0.48 11.2 1.4 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat IF-2B PF01008.17 KOO29407.1 - 3.5e-67 226.6 0.0 4.3e-67 226.3 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family LRR_4 PF12799.7 KOO29410.1 - 2.2e-19 69.2 6.8 1.4e-08 34.9 0.8 4.2 1 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO29410.1 - 1.1e-13 51.0 0.6 8.1e-07 28.7 0.1 2.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KOO29410.1 - 2.9e-10 39.8 25.2 5.2e-05 22.9 1.1 3.8 2 1 3 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 KOO29410.1 - 0.008 16.6 6.8 2.9 8.8 0.4 4.7 3 2 0 3 3 3 1 Leucine Rich Repeat LRR_6 PF13516.6 KOO29410.1 - 0.077 13.1 4.5 56 4.2 0.1 4.9 5 1 0 5 5 5 0 Leucine Rich repeat Glucosamine_iso PF01182.20 KOO29411.1 - 6.6e-66 222.4 0.0 1.2e-65 221.6 0.0 1.4 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PAC4 PF16093.5 KOO29411.1 - 1.1e-19 70.4 0.1 3e-19 69.0 0.0 1.8 2 0 0 2 2 2 1 Proteasome assembly chaperone 4 PAN_4 PF14295.6 KOO29412.1 - 4.7e-07 29.6 8.1 4.7e-07 29.6 8.1 1.8 2 0 0 2 2 2 1 PAN domain Pro_isomerase PF00160.21 KOO29412.1 - 5.6e-05 23.5 0.0 9.8e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Exo_endo_phos PF03372.23 KOO29413.1 - 3.8e-05 23.3 0.5 7.7e-05 22.3 0.5 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-TRAF PF02176.18 KOO29414.1 - 6.4e-05 23.6 2.2 6.4e-05 23.6 2.2 3.0 2 1 1 3 3 3 1 TRAF-type zinc finger zf-RING_UBOX PF13445.6 KOO29414.1 - 0.0003 20.8 4.3 0.0013 18.7 4.3 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOO29414.1 - 0.00053 19.8 2.8 0.00053 19.8 2.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO29414.1 - 0.0035 17.2 1.7 0.0035 17.2 1.7 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO29414.1 - 0.012 15.5 4.3 0.012 15.5 4.3 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ADIP PF11559.8 KOO29414.1 - 0.023 14.8 1.9 0.15 12.2 0.5 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Sina PF03145.16 KOO29414.1 - 0.19 11.7 6.5 4.1 7.3 0.8 2.3 1 1 1 2 2 2 0 Seven in absentia protein family zf-RING_2 PF13639.6 KOO29414.1 - 1.5 9.2 12.9 0.083 13.2 5.1 2.9 3 0 0 3 3 3 0 Ring finger domain Zn_ribbon_17 PF17120.5 KOO29414.1 - 2.8 7.6 9.2 0.74 9.5 4.6 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-TRAF_2 PF15965.5 KOO29414.1 - 3.6 8.1 10.1 0.098 13.1 2.5 2.3 1 1 1 2 2 2 0 TRAF-like zinc-finger CS PF04969.16 KOO29416.1 - 1.7e-09 38.5 0.3 2.4e-09 38.1 0.3 1.2 1 0 0 1 1 1 1 CS domain Serinc PF03348.15 KOO29417.1 - 6.1e-85 285.7 26.9 7.9e-85 285.4 26.9 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) FAM220 PF15487.6 KOO29418.1 - 0.75 9.4 2.6 3.6 7.1 2.6 2.2 2 0 0 2 2 2 0 FAM220 family XendoU PF09412.10 KOO29419.1 - 2.7e-45 154.7 0.1 3.2e-45 154.4 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU EndoU_bacteria PF14436.6 KOO29419.1 - 0.025 14.9 0.1 0.039 14.3 0.1 1.3 1 0 0 1 1 1 0 Bacterial EndoU nuclease zf-C2H2 PF00096.26 KOO29420.1 - 2.3e-10 40.3 17.2 0.00048 20.4 1.1 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOO29420.1 - 4.6e-07 30.1 17.0 0.0088 16.8 1.0 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOO29420.1 - 1.2e-05 25.4 7.9 0.0027 18.0 0.1 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 KOO29420.1 - 4.4e-05 23.7 11.9 0.61 10.6 3.7 3.9 3 1 0 3 3 3 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 KOO29420.1 - 0.00039 20.4 10.2 0.017 15.1 0.1 3.9 3 1 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 KOO29420.1 - 0.0067 16.8 6.4 0.17 12.3 0.5 3.1 3 0 0 3 3 2 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 KOO29420.1 - 0.11 12.6 1.6 1.4 9.1 0.3 2.7 2 1 0 2 2 2 0 Zinc ribbon domain zf-BED PF02892.15 KOO29420.1 - 0.68 10.0 5.4 22 5.2 2.4 2.7 2 1 0 2 2 2 0 BED zinc finger CpXC PF14353.6 KOO29420.1 - 2.9 8.0 5.5 0.83 9.7 0.9 2.2 1 1 1 2 2 2 0 CpXC protein zf-AN1 PF01428.16 KOO29420.1 - 3.7 7.8 7.3 26 5.1 0.1 3.4 3 0 0 3 3 3 0 AN1-like Zinc finger zf-C2H2_2 PF12756.7 KOO29420.1 - 5.9 7.3 11.3 11 6.4 0.3 3.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Indigoidine_A PF04227.12 KOO29421.1 - 2.1e-104 349.0 2.9 2.6e-104 348.7 2.9 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein TPP_enzyme_N PF02776.18 KOO29421.1 - 0.044 13.4 1.9 0.066 12.8 0.3 1.9 1 1 1 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain FixS PF03597.15 KOO29422.1 - 0.016 14.9 1.2 0.038 13.7 1.2 1.5 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type Kinesin PF00225.23 KOO29423.1 - 3.9e-26 91.8 0.0 1.9e-14 53.3 0.0 3.1 2 1 1 3 3 3 3 Kinesin motor domain Microtub_bd PF16796.5 KOO29423.1 - 0.0075 16.2 0.1 0.021 14.7 0.0 1.7 2 0 0 2 2 2 1 Microtubule binding ERp29_N PF07912.13 KOO29424.1 - 3.8e-30 104.6 0.4 7.6e-30 103.7 0.4 1.5 1 0 0 1 1 1 1 ERp29, N-terminal domain ERp29 PF07749.12 KOO29424.1 - 4.5e-25 88.4 3.5 6.9e-25 87.8 3.5 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Josephin PF02099.17 KOO29424.1 - 0.087 12.9 0.0 0.099 12.7 0.0 1.2 1 0 0 1 1 1 0 Josephin Flagellin_D3 PF08884.11 KOO29424.1 - 0.099 13.1 2.9 0.24 11.8 2.8 1.7 1 1 0 1 1 1 0 Flagellin D3 domain DPCD PF14913.6 KOO29425.1 - 5.5e-70 234.6 0.7 6.9e-70 234.3 0.7 1.0 1 0 0 1 1 1 1 DPCD protein family Pih1_fungal_CS PF18482.1 KOO29425.1 - 0.17 12.4 0.4 1.8 9.2 0.1 2.7 2 1 1 3 3 3 0 Fungal Pih1 CS domain SAP PF02037.27 KOO29426.1 - 0.015 15.0 0.2 0.17 11.6 0.2 2.8 1 1 0 1 1 1 0 SAP domain CENP-F_leu_zip PF10473.9 KOO29426.1 - 0.02 14.9 0.3 0.02 14.9 0.3 2.7 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 UBA_4 PF14555.6 KOO29426.1 - 0.025 14.4 0.0 0.089 12.6 0.0 1.9 1 0 0 1 1 1 0 UBA-like domain FlaC_arch PF05377.11 KOO29426.1 - 1.7 9.1 5.2 11 6.6 0.3 2.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Bcr-Abl_Oligo PF09036.10 KOO29426.1 - 3.6 7.7 6.3 1.7 8.7 0.1 3.1 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain cNMP_binding PF00027.29 KOO29427.1 - 6.4e-30 103.1 1.0 2.2e-13 50.1 0.0 4.4 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain EF-hand_1 PF00036.32 KOO29427.1 - 1.4e-09 36.8 0.1 0.00034 19.9 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO29427.1 - 2.2e-07 30.2 0.4 0.0079 16.1 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO29427.1 - 4.6e-07 29.0 4.2 0.0061 16.0 0.4 3.4 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO29427.1 - 0.00038 20.8 0.1 0.0012 19.2 0.1 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO29427.1 - 0.00093 19.0 0.0 0.0033 17.3 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair Lipocalin_2 PF08212.12 KOO29428.1 - 1.2e-16 60.9 0.0 1.4e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 Lipocalin-like domain PARP PF00644.20 KOO29429.1 - 4e-16 59.2 0.0 6.8e-16 58.4 0.0 1.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain zf-CW PF07496.15 KOO29430.1 - 1.4e-05 25.0 0.9 2.5e-05 24.2 0.9 1.5 1 0 0 1 1 1 1 CW-type Zinc Finger mRNA_triPase PF02940.15 KOO29432.1 - 6.1e-07 29.4 0.1 8.9e-07 28.9 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Ion_trans_2 PF07885.16 KOO29433.1 - 1.2e-27 95.7 22.8 5.1e-15 55.2 10.0 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KOO29433.1 - 5.1e-07 29.2 7.7 0.0011 18.2 0.7 2.2 2 0 0 2 2 2 2 Ion transport protein EF-hand_5 PF13202.6 KOO29433.1 - 0.00097 18.5 3.9 0.023 14.2 0.0 2.8 3 0 0 3 3 3 1 EF hand EF-hand_1 PF00036.32 KOO29433.1 - 0.0024 17.3 1.2 0.046 13.3 0.0 3.1 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 KOO29433.1 - 0.0033 17.2 1.5 0.025 14.5 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain IRK PF01007.20 KOO29433.1 - 0.046 13.5 2.7 3.9 7.3 0.1 2.3 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain EF-hand_7 PF13499.6 KOO29433.1 - 0.084 13.3 0.2 0.73 10.3 0.0 2.4 3 0 0 3 3 3 0 EF-hand domain pair DUF3829 PF12889.7 KOO29435.1 - 0.18 11.3 1.8 0.16 11.4 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) Binary_toxB_2 PF17475.2 KOO29435.1 - 0.27 10.9 0.8 0.68 9.6 0.2 2.0 2 0 0 2 2 2 0 Clostridial binary toxin B/anthrax toxin PA domain 2 EF-hand_6 PF13405.6 KOO29436.1 - 0.00039 20.1 0.1 0.00091 19.0 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO29436.1 - 0.00062 20.2 0.0 0.001 19.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO29436.1 - 0.0035 16.8 0.0 0.0066 15.9 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO29436.1 - 0.0062 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO29436.1 - 0.03 13.8 0.0 0.064 12.8 0.0 1.5 1 0 0 1 1 1 0 EF hand DUF4487 PF14868.6 KOO29436.1 - 0.11 11.2 0.1 0.15 10.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) Ank_2 PF12796.7 KOO29437.1 - 2e-20 73.2 2.4 4e-12 46.5 0.4 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO29437.1 - 1.8e-17 63.1 4.8 2.1e-06 27.9 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO29437.1 - 4.5e-16 59.0 0.4 6.3e-09 36.2 0.2 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO29437.1 - 6.3e-16 56.9 2.6 9.1e-05 22.6 0.2 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 KOO29437.1 - 1e-15 57.3 5.4 7e-06 26.2 0.6 4.5 4 0 0 4 4 4 3 Ankyrin repeat AAA PF00004.29 KOO29438.1 - 6.7e-10 39.5 0.0 1.2e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO29438.1 - 0.00094 19.6 0.0 0.0019 18.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KOO29438.1 - 0.0016 18.5 0.1 0.0047 16.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 KOO29438.1 - 0.0041 16.9 0.0 0.0066 16.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 KOO29438.1 - 0.0047 16.2 0.0 0.0069 15.6 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 KOO29438.1 - 0.0048 16.3 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KOO29438.1 - 0.0063 17.1 0.0 0.019 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOO29438.1 - 0.0097 16.2 0.1 0.16 12.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KOO29438.1 - 0.015 15.0 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RuvB_N PF05496.12 KOO29438.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOO29438.1 - 0.019 15.2 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO29438.1 - 0.048 13.8 0.2 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KOO29438.1 - 0.15 11.8 0.8 0.46 10.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 KOO29438.1 - 0.22 11.0 0.1 0.38 10.2 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein LRR_6 PF13516.6 KOO29439.1 - 3.2e-19 67.3 64.3 0.0016 18.4 0.3 18.1 20 1 0 20 20 20 8 Leucine Rich repeat LRR_4 PF12799.7 KOO29439.1 - 1.2e-08 35.0 8.2 13 6.3 0.0 9.1 10 1 0 10 10 10 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO29439.1 - 6.3e-07 29.1 8.3 67 4.6 0.1 10.4 13 0 0 13 13 13 0 Leucine Rich Repeat Metal_CEHH PF14455.6 KOO29439.1 - 5.8e-05 22.8 0.9 0.25 10.9 0.0 4.3 3 2 1 4 4 4 2 Predicted metal binding domain SLT_L PF14718.6 KOO29439.1 - 0.00064 19.8 0.2 15 5.8 0.0 4.3 4 0 0 4 4 4 1 Soluble lytic murein transglycosylase L domain LRR_8 PF13855.6 KOO29439.1 - 0.00096 18.9 14.2 9.3 6.1 0.0 8.7 10 2 0 10 10 10 1 Leucine rich repeat EIF_2_alpha PF07541.12 KOO29439.1 - 0.0048 17.0 2.0 15 5.7 0.0 6.0 4 2 0 5 5 5 1 Eukaryotic translation initiation factor 2 alpha subunit FIBP PF05427.11 KOO29439.1 - 0.087 12.1 0.1 1.9 7.7 0.0 2.7 4 0 0 4 4 4 0 Acidic fibroblast growth factor binding (FIBP) MttA_Hcf106 PF02416.16 KOO29439.1 - 0.41 10.0 3.7 56 3.2 0.0 5.0 6 0 0 6 6 6 0 mttA/Hcf106 family UBA PF00627.31 KOO29440.1 - 2.6e-06 27.2 1.3 6.9e-06 25.9 0.2 2.3 2 0 0 2 2 2 1 UBA/TS-N domain STI1 PF17830.1 KOO29440.1 - 0.014 15.3 44.1 0.02 14.8 10.2 4.0 1 1 2 3 3 3 0 STI1 domain CUE PF02845.16 KOO29440.1 - 0.029 14.1 0.0 0.074 12.8 0.0 1.7 1 0 0 1 1 1 0 CUE domain PSD5 PF07637.11 KOO29440.1 - 0.042 14.2 0.6 5.2 7.5 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1595) GerD PF17898.1 KOO29440.1 - 0.066 13.2 22.6 0.38 10.7 17.2 2.3 1 1 1 2 2 2 0 Spore germination GerD central core domain Com_YlbF PF06133.11 KOO29440.1 - 1.5 9.4 5.6 3.7 8.2 5.6 1.7 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA Bep_C_terminal PF17841.1 KOO29440.1 - 1.7 8.9 5.0 4.4 7.6 0.4 2.6 2 0 0 2 2 2 0 BID domain of Bartonella effector protein (Bep) TetR_C_28 PF17937.1 KOO29440.1 - 2.8 8.5 7.1 2.6 8.6 1.4 2.8 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Glyco_hydro_85 PF03644.13 KOO29442.1 - 4.2e-63 213.6 0.0 6e-63 213.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 LSM PF01423.22 KOO29442.1 - 5e-18 64.6 0.4 8.2e-18 63.9 0.4 1.3 1 0 0 1 1 1 1 LSM domain PUB PF09409.10 KOO29442.1 - 3.2e-15 55.8 0.0 6e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 PUB domain DUF5320 PF17253.2 KOO29443.1 - 0.00074 20.5 0.0 0.0022 19.0 0.0 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5320) MYO10_CC PF16735.5 KOO29443.1 - 0.057 13.5 5.5 4.7 7.4 0.2 2.6 2 0 0 2 2 2 0 Unconventional myosin-X coiled coil domain ZapB PF06005.12 KOO29443.1 - 7.4 7.1 10.2 0.34 11.4 1.1 2.7 2 0 0 2 2 2 0 Cell division protein ZapB LSDAT_euk PF18139.1 KOO29445.1 - 4e-45 154.3 0.0 6.3e-45 153.6 0.0 1.3 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 KOO29445.1 - 1.9e-30 105.6 0.3 3.4e-30 104.8 0.3 1.3 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 KOO29445.1 - 0.00056 19.2 1.4 0.0026 17.0 1.4 2.1 1 1 0 1 1 1 1 Ion transport protein Ank_2 PF12796.7 KOO29445.1 - 0.00092 19.8 0.3 0.017 15.7 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO29445.1 - 0.03 14.8 0.8 0.79 10.5 0.0 3.7 3 1 1 4 4 4 0 Ankyrin repeat LDcluster4 PF18306.1 KOO29445.1 - 0.065 12.8 0.2 0.62 9.6 0.1 2.1 2 0 0 2 2 2 0 SLOG cluster4 family Serinc PF03348.15 KOO29447.1 - 1.2e-68 232.0 22.0 1.8e-68 231.5 22.0 1.3 1 0 0 1 1 1 1 Serine incorporator (Serinc) Hydrolase_4 PF12146.8 KOO29448.1 - 2.6e-14 53.1 0.0 3.3e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ank_2 PF12796.7 KOO29449.1 - 5.2e-70 232.1 19.2 5.8e-07 30.0 0.1 12.6 6 3 9 15 15 15 15 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO29449.1 - 7.4e-69 226.9 22.2 4e-07 30.2 0.0 19.2 9 5 10 19 19 19 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO29449.1 - 7.9e-49 158.0 31.5 0.23 12.1 0.0 24.6 26 0 0 26 26 26 12 Ankyrin repeat Ank_4 PF13637.6 KOO29449.1 - 7.2e-42 141.3 14.8 0.00024 21.6 0.1 15.3 11 3 5 16 16 16 12 Ankyrin repeats (many copies) Ank PF00023.30 KOO29449.1 - 9.1e-28 95.5 47.7 0.096 13.2 0.0 22.8 24 1 1 25 25 25 5 Ankyrin repeat PgaPase_1 PF06162.12 KOO29449.1 - 0.0033 17.2 0.0 3.7 7.3 0.0 4.8 3 1 0 4 4 4 1 Putative pyroglutamyl peptidase PgaPase_1 mTERF PF02536.14 KOO29449.1 - 0.0035 16.3 0.0 1.1 8.1 0.0 4.1 5 0 0 5 5 5 1 mTERF DUF5492 PF17596.2 KOO29449.1 - 0.022 15.1 2.2 83 3.6 0.0 6.5 7 2 1 8 8 8 0 Family of unknown function (DUF5492) Nucleotid_trans PF03407.16 KOO29450.1 - 7.6e-27 94.7 0.0 1.1e-26 94.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF5642 PF18702.1 KOO29451.1 - 0.08 12.7 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5642) CCDC154 PF15450.6 KOO29451.1 - 0.087 11.3 0.5 0.14 10.6 0.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 154 NUDE_C PF04880.13 KOO29452.1 - 0.07 13.6 0.6 0.12 12.9 0.6 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Clathrin_H_link PF13838.6 KOO29453.1 - 0.14 12.1 1.3 1.2 9.1 0.2 2.6 2 0 0 2 2 2 0 Clathrin-H-link Ysc84 PF04366.12 KOO29454.1 - 9.3e-35 119.2 0.1 1.6e-34 118.4 0.1 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator FYVE PF01363.21 KOO29454.1 - 2.1e-18 66.2 7.3 3.5e-18 65.5 7.3 1.3 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 KOO29454.1 - 0.0078 16.4 2.0 0.013 15.7 2.0 1.3 1 0 0 1 1 1 1 FYVE-type zinc finger Clathrin PF00637.20 KOO29455.1 - 9.1e-18 64.5 13.9 0.012 15.5 0.0 10.4 4 2 7 11 11 11 5 Region in Clathrin and VPS ANAPC4_WD40 PF12894.7 KOO29455.1 - 7.8e-11 42.1 0.5 0.011 16.0 0.1 4.7 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 KOO29455.1 - 1e-06 28.1 8.0 0.00046 19.4 1.0 5.0 4 2 1 5 5 5 2 Coatomer WD associated region TPR_14 PF13428.6 KOO29455.1 - 1.1e-05 25.8 44.4 21 6.3 0.0 16.0 15 2 2 17 17 17 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO29455.1 - 0.0041 16.9 16.6 30 4.6 0.0 9.9 9 0 0 9 9 9 0 Tetratricopeptide repeat WD40 PF00400.32 KOO29455.1 - 0.0056 17.5 9.5 16 6.5 0.0 6.1 7 0 0 7 7 6 0 WD domain, G-beta repeat Mad3_BUB1_I PF08311.12 KOO29455.1 - 0.077 13.0 18.2 2.4 8.1 0.4 6.2 6 0 0 6 6 6 0 Mad3/BUB1 homology region 1 PPR PF01535.20 KOO29455.1 - 0.29 11.5 10.1 32 5.1 0.1 7.9 9 0 0 9 9 8 0 PPR repeat TPR_2 PF07719.17 KOO29455.1 - 1.5 9.1 41.9 28 5.2 0.2 13.5 16 0 0 16 16 16 0 Tetratricopeptide repeat MIT PF04212.18 KOO29455.1 - 3.5 7.8 14.2 49 4.1 0.1 6.9 8 0 0 8 8 8 0 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 KOO29455.1 - 4.7 7.7 19.6 73 4.0 0.1 8.9 10 0 0 10 10 10 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO29455.1 - 5.9 7.2 14.8 5.7 7.2 0.3 6.6 6 1 0 7 7 7 0 Anaphase-promoting complex, cyclosome, subunit 3 EF-hand_1 PF00036.32 KOO29458.1 - 2e-25 86.4 15.6 0.00032 20.1 0.0 7.5 7 0 0 7 7 7 6 EF hand EF-hand_6 PF13405.6 KOO29458.1 - 1.1e-23 81.1 13.8 0.0036 17.1 0.1 7.7 7 0 0 7 7 7 7 EF-hand domain EF-hand_7 PF13499.6 KOO29458.1 - 3.8e-20 72.1 6.1 1e-06 29.1 0.7 5.7 5 1 0 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO29458.1 - 1.1e-11 43.7 9.8 0.17 11.5 0.0 6.1 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO29458.1 - 1.7e-11 43.8 9.5 0.2 11.6 0.0 7.1 6 1 1 7 7 7 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO29458.1 - 0.016 15.5 1.8 12 6.3 0.0 4.3 2 2 1 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO29458.1 - 0.02 14.8 2.2 4.2 7.3 0.0 4.6 4 1 1 5 5 5 0 EF hand IQ PF00612.27 KOO29458.1 - 0.14 12.0 0.2 0.36 10.8 0.2 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif CDI PF02234.19 KOO29458.1 - 0.18 12.0 0.8 2.5 8.4 0.0 2.9 3 0 0 3 3 3 0 Cyclin-dependent kinase inhibitor Pkinase PF00069.25 KOO29459.1 - 4.1e-67 226.3 0.0 5.1e-67 226.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29459.1 - 1.9e-34 119.1 0.0 2.4e-34 118.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO29459.1 - 1.4e-07 31.1 0.0 2.3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO29459.1 - 0.057 13.3 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Engrail_1_C_sig PF10525.9 KOO29459.1 - 0.11 11.7 0.1 0.23 10.7 0.1 1.5 1 0 0 1 1 1 0 Engrailed homeobox C-terminal signature domain 2OG-FeII_Oxy_3 PF13640.6 KOO29461.1 - 2.7e-22 79.5 0.0 3.3e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO29461.1 - 4e-11 43.4 0.0 5.5e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4202 PF13875.6 KOO29461.1 - 0.1 12.5 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4202) Hydrolase_like PF13242.6 KOO29462.1 - 0.00014 21.9 0.1 0.00022 21.2 0.1 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KOO29462.1 - 0.0033 17.8 0.0 0.0088 16.4 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOO29462.1 - 0.012 15.7 0.0 0.015 15.4 0.0 1.1 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Na_sulph_symp PF00939.19 KOO29463.1 - 7.7e-63 213.2 9.2 3.8e-62 210.9 9.2 1.8 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KOO29463.1 - 1.9e-14 53.6 36.9 1.9e-14 53.6 36.9 2.8 1 1 1 2 2 2 1 Citrate transporter DcuC PF03606.15 KOO29463.1 - 0.1 11.0 12.6 0.18 10.2 12.6 1.3 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier DUF485 PF04341.12 KOO29463.1 - 3.8 7.5 8.0 0.17 11.9 0.9 2.4 3 0 0 3 3 3 0 Protein of unknown function, DUF485 Phosphodiest PF01663.22 KOO29465.1 - 2.8e-08 33.7 0.1 2.8e-08 33.7 0.1 2.0 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase ATG16 PF08614.11 KOO29465.1 - 0.011 16.0 16.2 0.011 16.0 16.2 3.3 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Glyco_trans_1_2 PF13524.6 KOO29465.1 - 0.034 14.5 0.2 5 7.6 0.0 3.1 2 0 0 2 2 2 0 Glycosyl transferases group 1 GAS PF13851.6 KOO29465.1 - 0.94 8.8 34.4 1.6 8.0 4.3 3.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 KOO29465.1 - 2.6 8.0 36.0 5 7.2 23.4 3.4 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Peptidase_M13_N PF05649.13 KOO29465.1 - 3.8 7.1 9.1 10 5.7 9.1 1.6 1 1 0 1 1 1 0 Peptidase family M13 Fez1 PF06818.15 KOO29465.1 - 7.6 6.9 26.8 1.2 9.6 17.4 2.4 2 0 0 2 2 2 0 Fez1 DSHCT PF08148.12 KOO29466.1 - 1.8e-37 128.5 3.7 1.8e-37 128.5 3.7 2.8 2 1 0 2 2 2 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 KOO29466.1 - 3.3e-27 96.1 1.6 8.4e-21 75.1 0.0 2.2 1 1 1 2 2 2 2 rRNA-processing arch domain DEAD PF00270.29 KOO29466.1 - 3.4e-20 72.5 0.0 6.7e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO29466.1 - 4.1e-06 27.1 0.0 9.7e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO29466.1 - 8.7e-05 22.6 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ABC_tran_CTD PF16326.5 KOO29466.1 - 0.045 14.0 0.9 0.045 14.0 0.9 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain EF-hand_7 PF13499.6 KOO29467.1 - 4.1e-11 43.2 0.5 5.9e-11 42.7 0.5 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO29467.1 - 5.5e-10 38.1 0.8 5.9e-05 22.3 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO29467.1 - 1.9e-08 33.6 0.2 0.0024 17.6 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO29467.1 - 9.6e-05 22.1 1.3 0.00022 21.0 0.2 2.1 1 1 1 2 2 2 1 EF-hand domain pair DUF4845 PF16137.5 KOO29467.1 - 0.18 12.7 0.0 0.27 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4845) ubiquitin PF00240.23 KOO29468.1 - 2.8e-34 116.7 0.3 3.4e-34 116.4 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOO29468.1 - 4.1e-16 58.6 0.3 5.4e-16 58.2 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_L41 PF05162.13 KOO29468.1 - 4.6e-08 33.0 26.1 9.7e-08 31.9 26.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L41 Ubiquitin_2 PF14560.6 KOO29468.1 - 2.9e-05 24.4 0.1 0.00011 22.5 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 KOO29468.1 - 0.0045 17.1 0.1 0.008 16.3 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 KOO29468.1 - 0.0057 17.0 0.0 0.01 16.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 KOO29468.1 - 0.013 15.4 0.0 0.017 15.1 0.0 1.2 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 KOO29468.1 - 0.032 14.8 0.4 0.041 14.4 0.4 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Lum_binding PF00677.17 KOO29469.1 - 1.1e-45 153.5 0.0 7.8e-22 77.1 0.0 2.1 2 0 0 2 2 2 2 Lumazine binding domain IFT81_CH PF18383.1 KOO29471.1 - 3.4e-36 124.2 0.2 3.4e-36 124.2 0.2 3.9 4 0 0 4 4 4 1 Intraflagellar transport 81 calponin homology domain ATG16 PF08614.11 KOO29471.1 - 0.003 17.8 12.4 0.003 17.8 12.4 5.2 1 1 4 5 5 5 2 Autophagy protein 16 (ATG16) ABC_tran_CTD PF16326.5 KOO29471.1 - 0.013 15.8 9.7 0.013 15.8 9.7 7.0 4 2 4 8 8 8 0 ABC transporter C-terminal domain Tyr_Deacylase PF02580.16 KOO29471.1 - 0.42 11.1 4.9 2.5 8.6 1.1 2.7 2 0 0 2 2 2 0 D-Tyr-tRNA(Tyr) deacylase SlyX PF04102.12 KOO29471.1 - 0.46 11.1 0.1 0.46 11.1 0.1 7.4 4 1 4 8 8 8 0 SlyX Anthrax_toxA PF03497.16 KOO29472.1 - 0.076 13.1 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Anthrax toxin LF subunit eIF2A PF08662.11 KOO29473.1 - 1.6e-66 223.9 0.0 2.2e-66 223.4 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A HEV_ORF1 PF02444.16 KOO29474.1 - 0.0022 18.6 0.3 0.0032 18.0 0.3 1.3 1 0 0 1 1 1 1 Hepatitis E virus ORF-2 (Putative capsid protein) MtmB PF05369.12 KOO29474.1 - 0.13 11.1 0.1 0.16 10.8 0.1 1.1 1 0 0 1 1 1 0 Monomethylamine methyltransferase MtmB COPIIcoated_ERV PF07970.12 KOO29477.1 - 3.3e-27 95.8 0.1 5.2e-27 95.1 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOO29477.1 - 5.6e-21 74.7 0.0 1.6e-20 73.2 0.0 1.8 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.20 KOO29477.1 - 2e-15 56.7 0.0 4e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 KOO29477.1 - 0.0097 16.1 0.1 0.031 14.4 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like Peptidase_M6 PF05547.11 KOO29481.1 - 7.2 4.8 6.0 8.9 4.5 0.7 2.0 2 0 0 2 2 2 0 Immune inhibitor A peptidase M6 Pkinase PF00069.25 KOO29482.1 - 2.2e-67 227.2 0.0 2.7e-67 226.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29482.1 - 1.8e-32 112.6 0.0 2.6e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO29482.1 - 0.0005 19.5 0.1 0.0008 18.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOO29482.1 - 0.0011 18.1 0.2 0.0016 17.5 0.2 1.4 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOO29482.1 - 0.012 15.5 0.1 0.023 14.6 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 KOO29482.1 - 0.04 13.5 0.1 0.061 12.9 0.1 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 YukC PF10140.9 KOO29482.1 - 0.12 11.2 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC MFA1_2 PF17317.2 KOO29482.1 - 4.7 7.1 4.9 2.8 7.8 0.0 2.6 3 0 0 3 3 3 0 Mating hormone A-factor 1&2 OmpA PF00691.20 KOO29483.1 - 0.0016 18.8 0.0 0.0064 16.9 0.0 1.9 2 0 0 2 2 2 1 OmpA family Pentapeptide PF00805.22 KOO29484.1 - 2.3e-20 71.9 17.2 1.5e-09 37.3 6.2 3.5 1 1 2 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 KOO29484.1 - 1.5e-13 50.7 2.0 5e-13 49.0 1.4 2.1 2 1 0 2 2 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 KOO29484.1 - 4e-12 46.1 6.4 3.4e-08 33.5 4.3 2.8 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) SIKE PF05769.11 KOO29484.1 - 0.0031 17.5 8.8 0.0046 16.9 8.8 1.2 1 0 0 1 1 1 1 SIKE family TolA_bind_tri PF16331.5 KOO29484.1 - 0.0044 17.1 9.6 0.01 15.9 9.6 1.5 1 0 0 1 1 1 1 TolA binding protein trimerisation Tmemb_cc2 PF10267.9 KOO29484.1 - 0.026 13.7 10.1 0.037 13.2 10.1 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein RPAP1_C PF08620.10 KOO29484.1 - 0.05 13.7 8.1 19 5.4 0.0 5.6 2 2 2 4 4 4 0 RPAP1-like, C-terminal TetR_C_15 PF17918.1 KOO29484.1 - 0.12 13.1 5.7 0.13 13.0 4.5 1.6 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain UPF0242 PF06785.11 KOO29484.1 - 0.2 11.8 6.1 0.3 11.2 6.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 KOO29484.1 - 0.22 11.1 5.8 0.32 10.5 5.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mto2_bdg PF12808.7 KOO29484.1 - 0.24 11.7 11.1 3 8.2 3.4 2.6 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region CENP-K PF11802.8 KOO29484.1 - 0.28 10.7 5.0 0.37 10.3 5.0 1.1 1 0 0 1 1 1 0 Centromere-associated protein K DUF1993 PF09351.10 KOO29484.1 - 0.33 11.1 6.9 0.28 11.3 4.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1993) Tup_N PF08581.10 KOO29484.1 - 0.34 11.3 5.9 0.76 10.1 5.9 1.7 1 0 0 1 1 1 0 Tup N-terminal Prominin PF05478.11 KOO29484.1 - 0.38 8.7 3.6 0.49 8.3 3.6 1.1 1 0 0 1 1 1 0 Prominin Atg14 PF10186.9 KOO29484.1 - 0.48 9.5 10.7 0.7 8.9 10.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 KOO29484.1 - 0.56 9.5 12.5 1.1 8.6 12.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 KOO29484.1 - 1.1 9.9 6.6 2.3 8.9 6.4 1.7 1 1 0 1 1 1 0 Initiation control protein YabA FUSC PF04632.12 KOO29484.1 - 4.4 5.7 12.4 5.5 5.4 12.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Zein-binding PF04576.15 KOO29484.1 - 5.4 7.4 20.0 7.3 7.0 0.9 3.5 1 1 2 3 3 3 0 Zein-binding Antigen_Bd37 PF11641.8 KOO29484.1 - 6.3 6.2 7.2 9.9 5.6 2.1 2.1 1 1 1 2 2 2 0 Glycosylphosphatidylinositol-anchored merozoite surface protein Spc7 PF08317.11 KOO29484.1 - 6.8 5.5 13.1 9.8 5.0 13.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein NAP PF00956.18 KOO29485.1 - 1.4e-07 31.0 0.1 3.7e-07 29.6 0.1 1.7 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) C2 PF00168.30 KOO29485.1 - 0.0053 17.0 0.0 0.023 15.0 0.0 2.0 2 0 0 2 2 2 1 C2 domain FlgN PF05130.12 KOO29485.1 - 2.6 8.6 4.9 0.49 10.9 1.2 1.7 2 0 0 2 2 2 0 FlgN protein Pox_A11 PF05061.13 KOO29486.1 - 0.019 14.3 2.1 0.031 13.5 2.1 1.3 1 0 0 1 1 1 0 Poxvirus A11 Protein DUF148 PF02520.17 KOO29486.1 - 2.9 8.0 14.0 0.058 13.5 5.5 2.7 3 0 0 3 3 3 0 Domain of unknown function DUF148 YojJ PF10372.9 KOO29486.1 - 8 6.6 7.7 35 4.6 0.7 3.9 2 2 2 4 4 4 0 Bacterial membrane-spanning protein N-terminus DUF4407 PF14362.6 KOO29486.1 - 8.5 5.6 33.7 0.16 11.3 10.9 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) COG5 PF10392.9 KOO29486.1 - 9.1 6.5 16.7 0.26 11.4 1.3 3.8 2 2 1 3 3 3 0 Golgi transport complex subunit 5 PHD PF00628.29 KOO29487.1 - 2.6e-14 52.8 17.8 1.3e-12 47.4 3.3 3.4 2 1 1 3 3 3 2 PHD-finger zf-PHD-like PF15446.6 KOO29487.1 - 0.011 15.4 0.1 0.011 15.4 0.1 2.8 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.6 KOO29487.1 - 0.012 15.1 0.6 0.012 15.1 0.6 4.0 4 1 0 4 4 4 0 PHD-finger C1_1 PF00130.22 KOO29487.1 - 0.02 14.8 0.1 0.02 14.8 0.1 3.3 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 KOO29487.1 - 0.025 14.7 0.3 0.025 14.7 0.3 2.7 2 1 1 3 3 3 0 KIAA1045 RING finger zf-RRPl_C4 PF17026.5 KOO29487.1 - 0.17 12.0 2.5 0.7 10.0 2.5 2.0 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-4CXXC_R1 PF10497.9 KOO29487.1 - 0.41 10.9 12.0 0.059 13.6 4.7 2.8 3 0 0 3 3 3 0 Zinc-finger domain of monoamine-oxidase A repressor R1 C1_2 PF03107.16 KOO29487.1 - 2.5 8.5 23.6 0.31 11.4 0.5 3.6 3 0 0 3 3 3 0 C1 domain Pentapeptide_3 PF13576.6 KOO29488.1 - 9.5e-16 57.7 11.9 2.4e-09 37.2 1.7 2.7 1 1 2 3 3 3 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 KOO29488.1 - 1.7e-15 56.3 5.4 1.2e-11 44.0 1.2 2.8 2 1 1 3 3 3 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 KOO29488.1 - 7.8e-10 38.8 0.6 4.2e-09 36.5 0.2 2.2 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) SIKE PF05769.11 KOO29488.1 - 0.00051 20.0 7.7 0.0007 19.6 7.7 1.1 1 0 0 1 1 1 1 SIKE family HOOK PF05622.12 KOO29488.1 - 0.015 13.5 9.0 0.02 13.0 9.0 1.1 1 0 0 1 1 1 0 HOOK protein DUF2717 PF10911.8 KOO29488.1 - 0.019 14.7 0.2 0.082 12.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2717) TolA_bind_tri PF16331.5 KOO29488.1 - 0.034 14.2 12.7 0.045 13.8 11.8 1.7 1 1 0 1 1 1 0 TolA binding protein trimerisation Tmemb_cc2 PF10267.9 KOO29488.1 - 0.048 12.8 8.6 0.068 12.3 8.6 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF4407 PF14362.6 KOO29488.1 - 0.17 11.2 11.9 0.25 10.7 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tup_N PF08581.10 KOO29488.1 - 0.2 12.0 6.5 0.43 10.9 6.5 1.6 1 0 0 1 1 1 0 Tup N-terminal DUF1993 PF09351.10 KOO29488.1 - 0.29 11.3 7.7 0.12 12.5 4.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1993) Tho2 PF11262.8 KOO29488.1 - 0.32 10.2 4.6 0.47 9.6 4.6 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Mto2_bdg PF12808.7 KOO29488.1 - 0.48 10.8 11.3 3.2 8.1 3.7 2.6 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Atg14 PF10186.9 KOO29488.1 - 0.9 8.6 8.7 1.3 8.1 8.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prominin PF05478.11 KOO29488.1 - 1.1 7.2 3.0 1.4 6.8 3.0 1.1 1 0 0 1 1 1 0 Prominin Phage_GPO PF05929.11 KOO29488.1 - 1.3 8.6 10.2 2.4 7.7 10.2 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3450 PF11932.8 KOO29488.1 - 1.4 8.2 14.7 2.1 7.6 14.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ZapB PF06005.12 KOO29488.1 - 1.8 9.1 12.0 4.6 7.8 12.0 1.7 1 0 0 1 1 1 0 Cell division protein ZapB YabA PF06156.13 KOO29488.1 - 2.1 9.0 6.7 3.6 8.3 6.3 1.7 1 1 0 1 1 1 0 Initiation control protein YabA FUSC PF04632.12 KOO29488.1 - 3.3 6.1 14.5 4.2 5.8 14.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Antigen_Bd37 PF11641.8 KOO29488.1 - 5.9 6.3 6.2 19 4.6 2.5 2.1 1 1 1 2 2 2 0 Glycosylphosphatidylinositol-anchored merozoite surface protein PARP PF00644.20 KOO29489.1 - 0.0026 17.4 0.0 0.0026 17.4 0.0 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PALP PF00291.25 KOO29491.1 - 4.8e-19 68.9 0.2 3.8e-18 65.9 0.2 1.9 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Plant_vir_prot PF01307.17 KOO29491.1 - 0.015 15.5 0.1 0.15 12.3 0.0 2.1 2 0 0 2 2 2 0 Plant viral movement protein SUI1 PF01253.22 KOO29492.1 - 3.3e-19 69.2 0.4 6.5e-19 68.2 0.4 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 Adaptin_N PF01602.20 KOO29493.1 - 1.6e-109 366.9 0.0 2.1e-109 366.5 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 KOO29493.1 - 2e-15 57.0 0.0 4.4e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 KOO29493.1 - 1.5e-13 51.0 0.0 2.8e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 KOO29493.1 - 1.4e-05 25.2 0.1 0.0037 17.3 0.0 2.9 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 ketoacyl-synt PF00109.26 KOO29495.1 - 1.2e-47 162.7 0.1 1.8e-47 162.1 0.1 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOO29495.1 - 5.3e-37 126.4 0.8 1.3e-36 125.2 0.2 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 KOO29495.1 - 0.00071 19.0 0.2 0.0021 17.5 0.2 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Ank PF00023.30 KOO29496.1 - 1.6e-07 31.5 1.2 0.053 14.0 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 KOO29496.1 - 2e-07 31.5 0.0 4.1e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO29496.1 - 2.4e-05 24.4 0.2 3.6 8.4 0.0 4.0 3 1 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 KOO29496.1 - 0.0024 18.4 0.1 1.6 9.4 0.0 3.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO29496.1 - 0.0027 18.0 0.1 0.0083 16.4 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) HRDC PF00570.23 KOO29498.1 - 5.1e-09 36.0 0.0 1.3e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 HRDC domain Transglut_core PF01841.19 KOO29499.1 - 8.9e-15 55.1 0.1 2e-14 54.0 0.1 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_core3 PF13471.6 KOO29499.1 - 0.00035 20.5 0.9 0.00035 20.5 0.9 2.9 2 1 1 3 3 3 1 Transglutaminase-like superfamily Peptidase_C25 PF01364.18 KOO29500.1 - 2.7e-33 115.7 0.3 3.4e-33 115.4 0.3 1.1 1 0 0 1 1 1 1 Peptidase family C25 Propeptide_C25 PF08126.11 KOO29500.1 - 2.8e-08 33.1 0.0 4.1e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Propeptide_C25 DUF4797 PF16051.5 KOO29500.1 - 0.16 11.9 0.1 3.1 7.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4797) GSH_synth_ATP PF03917.17 KOO29501.1 - 5.3e-90 301.9 0.0 6.4e-90 301.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 KOO29501.1 - 2.2e-28 98.7 0.0 3.5e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Pkinase PF00069.25 KOO29502.1 - 3.8e-39 134.6 0.0 7e-39 133.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29502.1 - 5.5e-12 45.5 0.0 8.4e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 KOO29502.1 - 0.081 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DWNN PF08783.11 KOO29503.1 - 7.8e-15 54.9 0.0 1.3e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 DWNN domain U-box PF04564.15 KOO29503.1 - 0.1 12.8 0.0 0.31 11.2 0.0 1.9 1 1 0 1 1 1 0 U-box domain zf-C3HC4_3 PF13920.6 KOO29503.1 - 0.1 12.4 0.4 0.19 11.6 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF5585 PF17823.1 KOO29503.1 - 2 7.3 20.8 2.8 6.8 20.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Sybindin PF04099.12 KOO29504.1 - 1.4e-31 109.4 0.0 1.5e-31 109.2 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 KOO29504.1 - 4e-06 27.0 0.0 1.8e-05 24.8 0.0 1.8 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region WD40 PF00400.32 KOO29505.1 - 3.5e-68 223.8 21.7 1.6e-08 35.0 0.1 9.2 9 0 0 9 9 9 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO29505.1 - 4.3e-27 94.2 2.3 9.7e-06 25.8 0.1 6.7 3 3 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 KOO29505.1 - 3.5e-12 46.7 0.1 6.3e-12 45.8 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 KOO29505.1 - 2.3e-10 40.0 0.0 0.00064 18.8 0.0 3.9 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KOO29505.1 - 2.4e-06 26.5 1.4 0.38 9.3 0.1 3.8 3 1 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 KOO29505.1 - 0.00056 19.3 0.0 1.2 8.4 0.0 3.7 4 0 0 4 4 4 1 WD40-like domain PD40 PF07676.12 KOO29505.1 - 0.0021 17.9 2.4 13 5.9 0.0 4.8 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 KOO29505.1 - 0.015 14.6 0.3 19 4.5 0.0 3.7 2 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.12 KOO29505.1 - 0.018 13.1 0.1 0.034 12.2 0.1 1.4 2 0 0 2 2 2 0 IKI3 family Frtz PF11768.8 KOO29505.1 - 0.024 13.0 0.0 0.21 9.9 0.0 2.0 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz SUKH-4 PF14435.6 KOO29505.1 - 0.026 14.6 0.2 1.5 8.9 0.0 3.3 2 2 1 3 3 3 0 SUKH-4 immunity protein 7TM-7TMR_HD PF07698.11 KOO29506.1 - 0.067 12.9 0.1 0.09 12.5 0.1 1.1 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF4407 PF14362.6 KOO29506.1 - 5.7 6.2 11.1 7.4 5.8 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BRE1 PF08647.11 KOO29507.1 - 0.00012 22.1 5.6 0.00012 22.1 5.6 8.4 4 3 2 7 7 7 3 BRE1 E3 ubiquitin ligase MMS1_N PF10433.9 KOO29508.1 - 1e-92 311.3 0.0 1.4e-92 310.9 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KOO29508.1 - 5.2e-71 239.6 0.0 1.2e-70 238.4 0.0 1.6 2 0 0 2 2 2 1 CPSF A subunit region cobW PF02492.19 KOO29510.1 - 4.7e-56 189.2 0.1 6.3e-56 188.7 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KOO29510.1 - 1.2e-18 66.8 0.0 2.1e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 KOO29510.1 - 0.0021 18.0 0.0 0.047 13.6 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KOO29510.1 - 0.0025 18.2 0.1 0.005 17.2 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 KOO29510.1 - 0.0063 17.0 0.5 0.013 16.0 0.4 1.4 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 KOO29510.1 - 0.0082 16.2 0.1 0.025 14.7 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase TsaE PF02367.17 KOO29510.1 - 0.012 15.6 0.1 0.025 14.6 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KOO29510.1 - 0.015 15.6 0.7 0.12 12.6 0.7 2.4 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOO29510.1 - 0.022 15.3 0.2 0.35 11.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain GTP_EFTU PF00009.27 KOO29510.1 - 0.028 13.9 0.9 0.31 10.6 0.8 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_30 PF13604.6 KOO29510.1 - 0.031 14.0 0.1 0.1 12.3 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOO29510.1 - 0.072 12.8 0.1 0.2 11.4 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 KOO29510.1 - 0.15 12.5 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 KOO29510.1 - 0.16 12.3 0.1 0.4 11.0 0.0 1.7 2 0 0 2 2 1 0 AAA domain DAP3 PF10236.9 KOO29510.1 - 0.17 11.0 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_33 PF13671.6 KOO29510.1 - 0.18 11.9 0.1 0.35 11.0 0.1 1.6 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 KOO29510.1 - 0.19 11.6 0.5 0.38 10.6 0.1 1.7 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.29 KOO29513.1 - 4e-59 198.8 0.0 1.2e-32 113.1 0.0 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO29513.1 - 4.4e-17 61.6 4.6 7.5e-08 32.1 1.5 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_5 PF07728.14 KOO29513.1 - 9.4e-06 25.7 0.1 0.00036 20.5 0.0 3.0 2 2 1 3 3 3 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOO29513.1 - 2e-05 24.4 0.0 0.00016 21.4 0.0 2.3 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO29513.1 - 0.00018 21.9 10.9 0.0013 19.2 0.1 4.5 4 1 1 5 5 5 1 AAA ATPase domain AAA_33 PF13671.6 KOO29513.1 - 0.00085 19.5 0.0 0.0027 17.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOO29513.1 - 0.003 17.8 0.3 0.094 13.0 0.1 2.9 2 1 1 3 3 3 1 AAA domain Mg_chelatase PF01078.21 KOO29513.1 - 0.013 14.9 0.2 0.046 13.1 0.1 1.8 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KOO29513.1 - 0.022 14.5 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.14 KOO29513.1 - 0.03 14.4 0.0 6.7 6.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) NACHT PF05729.12 KOO29513.1 - 0.07 13.0 0.0 1.3 8.9 0.0 2.7 1 1 1 2 2 2 0 NACHT domain TsaE PF02367.17 KOO29513.1 - 0.11 12.6 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 KOO29513.1 - 0.15 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KOO29513.1 - 0.15 11.7 0.0 1.1 8.9 0.0 2.4 2 1 0 2 2 2 0 Sigma-54 interaction domain TIP49 PF06068.13 KOO29513.1 - 0.31 10.2 0.0 0.53 9.4 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Bin3 PF06859.12 KOO29514.1 - 7.9e-07 29.7 0.0 3.1e-06 27.8 0.0 1.9 2 0 0 2 2 2 1 Bicoid-interacting protein 3 (Bin3) RRP14 PF15459.6 KOO29514.1 - 1.3 9.7 12.7 1.8 9.2 4.7 2.5 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 Tombus_movement PF05318.12 KOO29514.1 - 6.9 7.6 8.4 19 6.2 0.2 2.5 2 0 0 2 2 2 0 Tombusvirus movement protein ABC1 PF03109.16 KOO29515.1 - 1.9e-21 76.4 0.0 9.1e-21 74.2 0.0 1.9 2 0 0 2 2 2 1 ABC1 family APH PF01636.23 KOO29515.1 - 4.4e-05 23.5 5.1 6.8e-05 22.9 0.8 3.3 3 1 0 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 KOO29515.1 - 0.0001 22.0 0.0 0.00093 18.8 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 KOO29515.1 - 0.016 14.6 0.0 0.039 13.3 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain LRR_5 PF13306.6 KOO29517.1 - 2.8e-113 373.2 0.0 4.3e-35 120.5 0.0 4.2 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO29517.1 - 1.5e-21 75.9 0.0 0.31 10.9 0.0 10.1 3 2 10 13 13 13 10 Leucine rich repeat CCDC71L PF15374.6 KOO29518.1 - 0.69 9.1 10.0 0.78 9.0 10.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Spc7 PF08317.11 KOO29518.1 - 1 8.2 25.8 0.87 8.4 24.4 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Cytidylate_kin2 PF13189.6 KOO29518.1 - 2.6 8.1 9.9 13 5.9 9.9 1.9 1 1 0 1 1 1 0 Cytidylate kinase-like family Tox-ODYAM1 PF15642.6 KOO29518.1 - 3 6.7 13.4 0.088 11.8 6.6 1.7 1 1 1 2 2 2 0 Toxin in Odyssella and Amoebophilus Ax_dynein_light PF10211.9 KOO29518.1 - 6.6 6.6 26.3 0.46 10.4 7.7 2.2 1 1 0 2 2 2 0 Axonemal dynein light chain SLAIN PF15301.6 KOO29520.1 - 0.07 12.4 3.3 0.09 12.0 3.3 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family DUF515 PF04415.12 KOO29520.1 - 0.12 10.8 1.2 0.16 10.4 1.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) PHM7_cyt PF14703.6 KOO29521.1 - 0.18 12.0 0.0 0.34 11.1 0.0 1.5 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter ATPgrasp_ST PF14397.6 KOO29524.1 - 0.11 11.7 0.0 0.37 10.0 0.0 1.7 1 1 0 1 1 1 0 Sugar-transfer associated ATP-grasp tRNA_U5-meth_tr PF05958.11 KOO29525.1 - 1.5e-112 376.1 0.0 1.8e-112 375.9 0.0 1.0 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_25 PF13649.6 KOO29525.1 - 0.0012 19.6 0.0 0.0029 18.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO29525.1 - 0.0013 18.5 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO29525.1 - 0.0024 17.4 0.1 0.0062 16.1 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 KOO29525.1 - 0.0056 17.3 0.0 0.018 15.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOO29525.1 - 0.0091 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Met_10 PF02475.16 KOO29525.1 - 0.018 14.8 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_15 PF09445.10 KOO29525.1 - 0.033 13.8 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_12 PF08242.12 KOO29525.1 - 0.16 12.7 0.0 0.36 11.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PqiA PF04403.13 KOO29527.1 - 4.2e-06 26.7 2.9 4.2e-06 26.7 2.9 3.1 4 0 0 4 4 4 2 Paraquat-inducible protein A IBR PF01485.21 KOO29528.1 - 6.9e-15 55.0 44.2 7.3e-12 45.3 6.6 4.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 KOO29528.1 - 0.00081 19.3 8.6 0.00081 19.3 8.6 3.6 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOO29528.1 - 0.0013 18.5 5.1 0.0013 18.5 5.1 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO29528.1 - 0.0043 17.1 5.6 0.0043 17.1 5.6 3.7 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOO29528.1 - 0.0058 16.4 3.7 0.0058 16.4 3.7 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Kinesin PF00225.23 KOO29529.1 - 6.4e-88 294.9 0.0 1.3e-87 293.9 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO29529.1 - 6.5e-24 84.6 0.0 1.1e-23 83.8 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding TolA_bind_tri PF16331.5 KOO29529.1 - 0.0087 16.1 3.3 0.019 15.0 3.3 1.6 1 0 0 1 1 1 1 TolA binding protein trimerisation Syntaxin_2 PF14523.6 KOO29529.1 - 0.16 12.4 0.9 0.5 10.8 0.9 1.8 1 0 0 1 1 1 0 Syntaxin-like protein YabA PF06156.13 KOO29529.1 - 0.27 11.9 6.8 0.18 12.5 4.5 1.9 2 0 0 2 2 2 0 Initiation control protein YabA V_ATPase_I PF01496.19 KOO29529.1 - 3.8 5.3 9.2 4.9 4.9 9.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDRGK PF09756.9 KOO29530.1 - 7e-49 166.0 15.7 8.3e-49 165.7 15.7 1.1 1 0 0 1 1 1 1 DDRGK domain FeoC PF09012.10 KOO29530.1 - 0.00046 20.2 0.4 0.051 13.7 0.1 2.5 2 0 0 2 2 2 1 FeoC like transcriptional regulator DHQS PF01959.16 KOO29530.1 - 0.034 13.1 6.7 0.042 12.8 6.7 1.0 1 0 0 1 1 1 0 3-dehydroquinate synthase II DUF1825 PF08855.10 KOO29530.1 - 0.07 13.1 1.2 0.14 12.1 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1825) RPA_C PF08784.11 KOO29530.1 - 0.072 13.8 0.1 0.11 13.1 0.1 1.5 1 1 0 1 1 1 0 Replication protein A C terminal UPF0240 PF06784.11 KOO29530.1 - 0.1 12.6 2.9 0.17 11.9 2.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) PTEN_C2 PF10409.9 KOO29531.1 - 5.9e-17 61.7 0.2 1.3e-09 37.9 0.1 3.3 3 0 0 3 3 3 3 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 KOO29531.1 - 8.1e-15 54.8 0.0 3.9e-07 30.0 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOO29531.1 - 2e-10 40.6 0.0 0.00013 21.6 0.0 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KOO29531.1 - 2.1e-09 37.7 0.0 0.0011 19.0 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KOO29531.1 - 3.4e-07 30.5 0.1 0.0066 16.6 0.0 2.3 2 0 0 2 2 2 2 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 KOO29531.1 - 0.00068 19.3 0.0 0.7 9.4 0.0 2.5 2 0 0 2 2 2 2 Tyrosine phosphatase family XET_C PF06955.12 KOO29531.1 - 0.46 10.4 5.4 11 6.0 0.5 2.5 2 0 0 2 2 2 0 Xyloglucan endo-transglycosylase (XET) C-terminus LapA_dom PF06305.11 KOO29533.1 - 0.58 10.0 1.9 0.56 10.1 0.3 1.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Flu_M1_C PF08289.11 KOO29533.1 - 2 8.7 5.6 4.3 7.6 5.3 1.6 1 1 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Abhydrolase_1 PF00561.20 KOO29534.1 - 3.5e-13 49.8 0.0 9.3e-09 35.3 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO29534.1 - 3.5e-07 29.8 0.0 0.0015 17.8 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO29534.1 - 1.5e-05 25.7 2.2 0.048 14.3 0.2 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Pro_CA PF00484.19 KOO29535.1 - 3.1e-43 147.8 0.3 4.2e-43 147.3 0.3 1.2 1 0 0 1 1 1 1 Carbonic anhydrase DUF2540 PF10802.8 KOO29535.1 - 0.043 13.9 0.0 0.078 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) Pkinase PF00069.25 KOO29536.1 - 5.9e-45 153.7 0.0 8.4e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29536.1 - 1e-38 133.1 0.0 1.7e-38 132.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO29536.1 - 0.0014 17.5 0.0 0.0023 16.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO29536.1 - 0.025 13.9 0.0 0.04 13.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 KOO29536.1 - 0.047 13.6 0.1 0.45 10.4 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family DHC_N1 PF08385.12 KOO29537.1 - 2.4e-156 521.7 2.9 2.4e-156 521.7 2.9 3.7 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 KOO29537.1 - 5.2e-151 502.2 0.0 1.9e-150 500.4 0.0 2.0 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO29537.1 - 1.7e-125 419.2 9.5 1.7e-125 419.2 9.5 4.9 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO29537.1 - 4.3e-91 304.8 0.0 9.4e-91 303.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KOO29537.1 - 2e-81 272.3 1.5 5e-81 271.0 0.4 2.4 2 0 0 2 2 2 1 ATP-binding dynein motor region Dynein_C PF18199.1 KOO29537.1 - 5.2e-78 262.4 0.0 2e-77 260.4 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 KOO29537.1 - 9.6e-71 237.0 1.1 5.5e-65 218.3 0.0 3.8 4 0 0 4 4 4 3 P-loop containing dynein motor region MT PF12777.7 KOO29537.1 - 3.3e-53 180.9 16.5 7.8e-53 179.7 16.5 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 KOO29537.1 - 3.4e-53 179.8 0.0 4e-52 176.4 0.0 2.6 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO29537.1 - 1.8e-41 141.0 0.0 1.5e-40 138.0 0.0 2.7 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 KOO29537.1 - 8.7e-20 71.1 0.0 5.5e-05 23.2 0.0 5.9 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 KOO29537.1 - 1e-17 64.4 0.2 6.8e-17 61.8 0.0 2.7 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KOO29537.1 - 3.5e-12 46.4 0.0 3e-11 43.4 0.0 2.8 2 0 0 2 2 1 1 AAA+ lid domain AAA_16 PF13191.6 KOO29537.1 - 1e-07 32.5 1.1 3.3 8.1 0.0 6.3 6 0 0 6 6 6 2 AAA ATPase domain AAA_22 PF13401.6 KOO29537.1 - 2.4e-06 27.8 0.3 0.33 11.2 0.0 4.7 4 0 0 4 4 4 2 AAA domain AAA PF00004.29 KOO29537.1 - 0.0045 17.4 4.4 6.1 7.3 0.1 4.9 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOO29537.1 - 0.0072 16.1 1.9 5.6 6.6 0.0 4.0 4 0 0 4 4 4 1 AAA domain AAA_29 PF13555.6 KOO29537.1 - 0.013 15.2 0.5 45 3.9 0.0 3.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_25 PF13481.6 KOO29537.1 - 0.019 14.6 0.5 2.4 7.7 0.0 3.3 3 0 0 3 3 2 0 AAA domain Adeno_IVa2 PF02456.15 KOO29537.1 - 0.05 12.4 0.1 0.12 11.1 0.1 1.5 1 0 0 1 1 1 0 Adenovirus IVa2 protein Pro-rich PF15240.6 KOO29537.1 - 0.71 10.1 23.8 1.3 9.3 23.8 1.3 1 0 0 1 1 1 0 Proline-rich Med22 PF06179.12 KOO29537.1 - 6 7.1 7.5 3.8 7.8 2.3 3.4 3 0 0 3 3 3 0 Surfeit locus protein 5 subunit 22 of Mediator complex EF-hand_1 PF00036.32 KOO29538.1 - 4.2e-51 166.7 3.3 3.7e-05 23.0 0.0 10.2 8 2 2 10 10 10 9 EF hand EF-hand_6 PF13405.6 KOO29538.1 - 4.7e-44 144.6 17.3 1.7e-06 27.5 0.0 10.2 6 4 4 10 10 10 8 EF-hand domain EF-hand_7 PF13499.6 KOO29538.1 - 1.1e-40 137.9 5.8 1.1e-08 35.4 0.0 5.6 5 1 1 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO29538.1 - 4.8e-36 120.7 11.2 9.3e-05 21.8 0.0 8.9 9 0 0 9 9 9 8 EF hand EF-hand_8 PF13833.6 KOO29538.1 - 2.5e-25 88.1 13.3 5e-05 23.1 0.0 9.4 5 4 4 9 9 9 9 EF-hand domain pair Caleosin PF05042.13 KOO29538.1 - 2.3e-07 30.9 0.1 0.39 10.6 0.0 5.5 3 1 3 6 6 6 1 Caleosin related protein EF-hand_9 PF14658.6 KOO29538.1 - 1.7e-06 28.2 0.9 6.3 7.2 0.0 5.1 4 1 1 5 5 5 1 EF-hand domain EF-hand_10 PF14788.6 KOO29538.1 - 5.6e-05 22.9 0.8 1 9.3 0.0 4.9 5 1 1 6 6 6 2 EF hand UPF0242 PF06785.11 KOO29538.1 - 0.0022 18.1 0.4 0.0032 17.6 0.4 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus CorA PF01544.18 KOO29538.1 - 0.1 11.9 0.2 0.16 11.3 0.2 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF5640 PF18692.1 KOO29538.1 - 0.1 12.6 0.0 19 5.4 0.0 3.7 4 1 0 4 4 4 0 Family of unknown function (DUF5640) Use1 PF09753.9 KOO29538.1 - 0.18 11.5 3.2 0.35 10.6 3.2 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 Herpes_UL36 PF03586.13 KOO29538.1 - 0.19 11.0 0.6 1.8 7.8 0.3 2.3 2 0 0 2 2 2 0 Herpesvirus UL36 tegument protein Dockerin_1 PF00404.18 KOO29538.1 - 0.19 11.9 4.8 6.6 7.0 0.1 4.0 5 0 0 5 5 5 0 Dockerin type I domain U-box PF04564.15 KOO29539.1 - 1.1e-22 80.0 0.1 4.6e-10 39.5 0.0 2.4 2 0 0 2 2 2 2 U-box domain Ank_2 PF12796.7 KOO29539.1 - 9.1e-10 39.0 0.6 6.6e-09 36.2 0.3 2.4 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) zf-Nse PF11789.8 KOO29539.1 - 9.1e-08 31.8 0.0 0.011 15.5 0.0 2.6 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO29539.1 - 9.9e-08 32.0 0.0 0.022 14.9 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger of nitric oxide synthase-interacting protein Ank_5 PF13857.6 KOO29539.1 - 6.2e-06 26.4 0.1 0.00074 19.8 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO29539.1 - 1.5e-05 25.2 1.5 0.00061 20.1 0.1 3.6 4 0 0 4 4 4 1 Ankyrin repeat DUF5097 PF17020.5 KOO29539.1 - 0.0018 18.6 0.0 1.7 9.0 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF5097) Ank_4 PF13637.6 KOO29539.1 - 0.0018 18.8 0.1 0.28 11.8 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Germane PF10646.9 KOO29539.1 - 0.0073 17.1 0.0 18 6.2 0.0 3.3 1 1 1 3 3 3 0 Sporulation and spore germination Ank_3 PF13606.6 KOO29539.1 - 0.024 15.2 0.1 1.6 9.6 0.1 3.4 4 0 0 4 4 3 0 Ankyrin repeat 2C_adapt PF08793.10 KOO29539.1 - 0.043 14.0 0.0 7.9 6.8 0.0 2.8 2 0 0 2 2 2 0 2-cysteine adaptor domain HTH_9 PF08221.11 KOO29539.1 - 0.061 13.4 0.0 8.5 6.6 0.0 2.7 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain zf-rbx1 PF12678.7 KOO29539.1 - 0.093 13.0 0.0 21 5.5 0.0 2.7 2 1 0 2 2 2 0 RING-H2 zinc finger domain DUF2680 PF10925.8 KOO29539.1 - 0.12 12.4 0.0 6.5 6.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) YdfZ PF14001.6 KOO29539.1 - 0.49 10.9 4.0 2 8.9 0.1 2.8 3 0 0 3 3 2 0 YdfZ protein Glyco_hydro_59 PF02057.15 KOO29540.1 - 4.1e-111 370.9 0.2 5e-111 370.6 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_59M PF17387.2 KOO29540.1 - 2.2e-30 105.2 0.0 4.1e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 central domain Glyco_hydro_30 PF02055.16 KOO29540.1 - 0.041 12.8 0.7 0.074 12.0 0.0 1.7 2 1 0 2 2 2 0 Glycosyl hydrolase family 30 TIM-barrel domain Ank PF00023.30 KOO29542.1 - 0.11 13.0 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 Ankyrin repeat DUF3589 PF12141.8 KOO29543.1 - 0.065 11.8 0.0 0.098 11.2 0.0 1.1 1 0 0 1 1 1 0 Beta-mannosyltransferases Exostosin PF03016.15 KOO29544.1 - 2.9e-08 33.3 0.0 1.3e-07 31.1 0.0 1.9 1 1 0 1 1 1 1 Exostosin family EF-hand_6 PF13405.6 KOO29545.1 - 1.2e-17 62.3 3.3 0.0039 17.0 0.1 6.4 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.6 KOO29545.1 - 2.3e-16 60.0 6.7 0.01 16.3 0.3 6.1 5 1 0 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.32 KOO29545.1 - 7.1e-13 47.1 6.9 0.0069 15.9 0.2 6.4 6 0 0 6 6 6 4 EF hand EF-hand_5 PF13202.6 KOO29545.1 - 1.9e-08 33.4 7.7 0.00013 21.3 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO29545.1 - 7.4e-08 32.1 6.7 0.044 13.6 0.1 5.8 6 0 0 6 6 6 3 EF-hand domain pair CBFD_NFYB_HMF PF00808.23 KOO29546.1 - 4.3e-06 26.9 0.0 6.7e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2884 PF11101.8 KOO29546.1 - 0.014 14.9 0.1 0.017 14.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) His_Phos_1 PF00300.22 KOO29547.1 - 1.1e-06 28.5 1.3 5.7e-06 26.1 0.2 2.3 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Na_Ca_ex PF01699.24 KOO29548.1 - 4.2e-29 101.5 21.5 1.3e-16 60.9 9.1 2.1 1 1 1 2 2 2 2 Sodium/calcium exchanger protein EF-hand_1 PF00036.32 KOO29549.1 - 1.9e-09 36.4 0.1 0.0013 18.1 0.0 2.4 2 0 0 2 2 2 2 EF hand LETM1 PF07766.13 KOO29549.1 - 1.6e-07 31.0 0.1 2.9e-07 30.1 0.1 1.3 1 0 0 1 1 1 1 LETM1-like protein EF-hand_7 PF13499.6 KOO29549.1 - 1.6e-07 31.6 0.1 4.3e-07 30.3 0.1 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO29549.1 - 1.4e-06 27.7 0.1 0.0052 16.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO29549.1 - 6.9e-05 22.6 0.0 0.017 15.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO29549.1 - 0.0051 16.3 0.4 0.22 11.1 0.1 2.4 2 0 0 2 2 2 1 EF hand DUF4116 PF13475.6 KOO29550.1 - 1.8e-54 181.2 0.0 1.2e-14 53.7 0.0 5.2 2 2 2 5 5 5 4 Domain of unknown function (DUF4116) EF-hand_1 PF00036.32 KOO29550.1 - 3.1e-16 57.6 0.5 5.5e-07 28.7 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO29550.1 - 5.8e-12 45.9 0.0 1.2e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO29550.1 - 8.4e-12 44.0 0.0 4.5e-06 26.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO29550.1 - 1.7e-11 43.7 0.9 1.1e-10 41.2 0.2 2.2 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO29550.1 - 3.1e-09 35.9 2.9 0.00013 21.3 0.0 3.4 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 KOO29550.1 - 6.2e-05 23.3 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain Rsbr_N PF08678.10 KOO29550.1 - 0.00026 21.1 0.0 6.9 6.8 0.0 4.0 1 1 4 5 5 5 2 Rsbr N terminal EF-hand_4 PF12763.7 KOO29550.1 - 0.0079 16.1 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand S-l_SbsC_C PF18316.1 KOO29550.1 - 0.016 15.7 9.5 7.8 7.1 0.1 5.0 1 1 1 4 4 4 0 S-layer protein SbsC C-terminal domain Mersacidin PF16934.5 KOO29550.1 - 0.023 14.4 8.2 0.22 11.3 0.1 4.1 4 0 0 4 4 4 0 Two-component Enterococcus faecalis cytolysin (EFC) PRA-CH PF01502.18 KOO29550.1 - 0.038 13.8 0.5 1.1e+02 2.8 0.0 4.5 1 1 3 5 5 5 0 Phosphoribosyl-AMP cyclohydrolase DUF1667 PF07892.11 KOO29550.1 - 0.11 12.6 0.1 93 3.2 0.0 3.7 1 1 2 4 4 4 0 Protein of unknown function (DUF1667) CbiG_C PF01890.16 KOO29550.1 - 0.14 12.7 13.2 3.9 8.1 0.1 4.9 1 1 3 4 4 4 0 Cobalamin synthesis G C-terminus SPARC_Ca_bdg PF10591.9 KOO29550.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Bestrophin PF01062.21 KOO29552.1 - 1.9e-35 122.7 1.0 2.8e-35 122.2 1.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Beach PF02138.18 KOO29552.1 - 0.026 13.9 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 Beige/BEACH domain Sugar_tr PF00083.24 KOO29553.1 - 0.046 12.6 0.5 0.062 12.2 0.5 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter US30 PF17624.2 KOO29553.1 - 0.12 11.4 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function PRRSV_2b PF07069.11 KOO29553.1 - 0.57 10.7 2.4 1.2 9.7 2.4 1.5 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b 7tm_3 PF00003.22 KOO29554.1 - 0.098 12.4 6.6 0.12 12.1 6.6 1.1 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR DUF4407 PF14362.6 KOO29554.1 - 0.38 10.1 4.5 0.51 9.6 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3742 PF12553.8 KOO29554.1 - 4.1 7.5 8.8 1.1 9.4 4.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3742) MatE PF01554.18 KOO29555.1 - 0.00048 19.8 5.8 0.00048 19.8 5.8 2.4 2 1 1 3 3 3 1 MatE DUF443 PF04276.12 KOO29555.1 - 0.28 11.0 7.5 0.62 9.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF443) DHHC PF01529.20 KOO29555.1 - 2.8 8.1 10.3 0.36 11.0 0.4 2.6 2 1 0 2 2 2 0 DHHC palmitoyltransferase FAD_binding_6 PF00970.24 KOO29556.1 - 8.5e-22 77.4 0.0 1.8e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain MlaD PF02470.20 KOO29556.1 - 0.086 13.2 0.1 0.26 11.6 0.1 1.8 1 0 0 1 1 1 0 MlaD protein Pkinase PF00069.25 KOO29557.1 - 5.1e-44 150.6 0.0 5.8e-44 150.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29557.1 - 9.2e-31 107.1 0.1 1e-30 106.9 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO29557.1 - 0.00023 20.6 0.0 0.0003 20.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO29557.1 - 0.00034 19.5 0.0 0.00042 19.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO29557.1 - 0.067 13.1 0.5 1.3 8.9 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO29557.1 - 0.17 11.2 0.1 0.21 10.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Adap_comp_sub PF00928.21 KOO29558.1 - 4.4e-15 55.8 0.0 7.9e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KOO29558.1 - 1.7e-07 31.2 0.2 3e-07 30.5 0.1 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 KOO29558.1 - 0.0035 16.8 0.0 0.0054 16.2 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain PTPLA PF04387.14 KOO29560.1 - 1.4e-05 24.9 0.4 0.036 13.8 0.1 2.3 1 1 1 2 2 2 2 Protein tyrosine phosphatase-like protein, PTPLA MMR_HSR1 PF01926.23 KOO29562.1 - 5.1e-23 81.3 0.0 8e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.22 KOO29562.1 - 3.4e-12 46.2 0.1 6.2e-12 45.4 0.1 1.4 1 0 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.18 KOO29562.1 - 9.6e-07 28.5 0.0 2.8e-06 26.9 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B PduV-EutP PF10662.9 KOO29562.1 - 0.02 14.6 0.0 0.066 13.0 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 KOO29562.1 - 0.069 12.9 0.0 0.5 10.1 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DnaJ PF00226.31 KOO29563.1 - 1.4e-15 57.2 1.3 4.3e-15 55.6 0.0 2.6 3 0 0 3 3 3 1 DnaJ domain PP2C PF00481.21 KOO29564.1 - 5e-35 121.4 0.0 8.3e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO29564.1 - 1.7e-06 27.9 0.9 6.7e-06 25.9 0.2 2.3 1 1 1 2 2 2 1 Protein phosphatase 2C VitK2_biosynth PF02621.14 KOO29564.1 - 0.12 11.8 0.1 0.24 10.9 0.1 1.4 1 0 0 1 1 1 0 Menaquinone biosynthesis Toxin_28 PF08115.11 KOO29564.1 - 0.23 11.3 0.4 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 SFI toxin family UPF0004 PF00919.20 KOO29565.1 - 4e-28 97.3 0.1 1.2e-27 95.8 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 KOO29565.1 - 2.7e-20 73.4 0.0 5.8e-20 72.3 0.0 1.6 2 0 0 2 2 2 1 Radical SAM superfamily TRAM_2 PF18693.1 KOO29565.1 - 3.5e-10 39.9 0.2 2.4e-09 37.2 0.1 2.3 2 0 0 2 2 2 1 TRAM domain WD40 PF00400.32 KOO29566.1 - 2.5e-23 81.9 16.9 2.3e-06 28.2 0.4 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat Sof1 PF04158.14 KOO29566.1 - 7.6e-23 80.6 10.7 1.4e-22 79.8 10.7 1.4 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 KOO29566.1 - 0.0006 20.1 0.0 2.4 8.5 0.0 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO29566.1 - 0.1 11.5 0.1 4.5 6.1 0.0 2.6 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Baculo_LEF-11 PF06385.12 KOO29566.1 - 0.11 13.0 0.0 25 5.5 0.0 2.7 2 0 0 2 2 2 0 Baculovirus LEF-11 protein Kinesin PF00225.23 KOO29567.1 - 3.3e-129 430.6 9.9 7.1e-108 360.5 0.7 4.1 5 0 0 5 5 5 2 Kinesin motor domain Microtub_bd PF16796.5 KOO29567.1 - 1.2e-42 145.3 0.1 1.2e-41 142.2 0.1 2.5 2 0 0 2 2 2 1 Microtubule binding VHS PF00790.19 KOO29567.1 - 3.5e-06 26.9 0.2 1.9e-05 24.5 0.0 2.4 2 1 0 2 2 2 1 VHS domain TPR_12 PF13424.6 KOO29567.1 - 4.7e-05 23.6 4.0 4.7e-05 23.6 4.0 3.0 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO29567.1 - 0.00084 19.2 0.3 0.062 13.3 0.1 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO29567.1 - 0.96 9.8 9.0 2.2 8.7 0.3 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO29567.1 - 3.2 7.7 4.3 14 5.7 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO29567.1 - 6.2 6.8 9.3 1.2 9.1 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PAS_9 PF13426.7 KOO29568.1 - 6.8e-09 35.9 0.0 1.7e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 KOO29568.1 - 0.0043 17.0 0.0 0.0074 16.3 0.0 1.4 1 0 0 1 1 1 1 PAS fold Myb_DNA-binding PF00249.31 KOO29569.1 - 0.0038 17.4 0.2 0.009 16.2 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO29569.1 - 0.17 12.1 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Ank_2 PF12796.7 KOO29570.1 - 1.2e-21 77.1 0.7 9.6e-13 48.5 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO29570.1 - 2.4e-12 45.9 0.1 0.009 16.5 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO29570.1 - 2.5e-12 46.6 2.4 0.011 16.1 0.1 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO29570.1 - 2e-11 43.9 0.6 1.1e-06 28.7 0.2 2.9 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO29570.1 - 3.9e-09 36.9 0.1 2.4e-06 27.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Nucleotid_trans PF03407.16 KOO29571.1 - 1.2e-30 107.0 0.0 1.9e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase 3HCDH_N PF02737.18 KOO29572.1 - 3.6e-67 225.7 1.2 1.2e-52 178.4 0.3 3.6 5 0 0 5 5 3 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 KOO29572.1 - 3.1e-66 223.2 14.7 6.2e-33 114.2 3.5 2.5 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOO29572.1 - 1.2e-46 159.8 9.7 5.2e-23 82.1 1.5 2.3 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase EF-hand_1 PF00036.32 KOO29572.1 - 6.6e-33 109.8 0.7 4e-06 26.0 0.1 6.6 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.6 KOO29572.1 - 4.4e-30 101.0 1.7 2.8e-06 26.8 0.1 6.7 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.6 KOO29572.1 - 1.6e-29 102.1 0.0 8.8e-11 42.1 0.2 4.0 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO29572.1 - 1.8e-26 90.4 4.9 1.8e-06 27.2 0.2 5.5 5 0 0 5 5 5 5 EF hand 3HCDH PF00725.22 KOO29572.1 - 1.5e-25 89.6 0.1 6.2e-20 71.6 0.0 3.5 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain EF-hand_8 PF13833.6 KOO29572.1 - 2.7e-16 59.1 3.7 0.022 14.6 0.0 6.0 5 0 0 5 5 5 5 EF-hand domain pair 3HCDH_RFF PF18321.1 KOO29572.1 - 1.2e-05 25.6 0.4 2.7 8.5 0.0 4.0 3 0 0 3 3 3 2 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain NAD_binding_8 PF13450.6 KOO29572.1 - 5.5e-05 23.3 1.1 0.57 10.5 0.1 3.0 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain EF-hand_11 PF08976.11 KOO29572.1 - 0.00096 20.0 0.0 0.17 12.8 0.0 3.4 4 0 0 4 4 4 1 EF-hand domain Caleosin PF05042.13 KOO29572.1 - 0.0025 17.8 0.4 3.3 7.6 0.0 4.8 6 0 0 6 6 6 1 Caleosin related protein 2-Hacid_dh_C PF02826.19 KOO29572.1 - 0.0036 16.7 7.8 0.37 10.1 0.1 3.1 4 0 0 4 4 4 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 KOO29572.1 - 0.004 17.2 0.1 3.6 7.5 0.0 3.2 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF3798 PF12683.7 KOO29572.1 - 0.0043 16.5 5.4 0.88 8.9 0.5 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3798) NAD_binding_2 PF03446.15 KOO29572.1 - 0.0053 16.9 10.8 0.24 11.6 0.0 3.7 4 0 0 4 4 4 2 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 KOO29572.1 - 0.037 14.6 13.2 0.77 10.4 0.7 4.2 4 0 0 4 4 2 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.27 KOO29572.1 - 0.66 10.6 7.8 13 6.4 0.2 3.9 4 0 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO29572.1 - 1.4 8.4 6.8 5.4 6.5 0.0 2.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase Nucleoporin_FG PF13634.6 KOO29572.1 - 5 8.0 5.7 47 4.9 0.5 2.5 2 0 0 2 2 2 0 Nucleoporin FG repeat region Sdh_cyt PF01127.22 KOO29574.1 - 0.03 14.3 0.3 0.03 14.3 0.3 2.0 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Phage_holin_3_6 PF07332.11 KOO29574.1 - 0.036 14.1 0.0 0.067 13.2 0.0 1.4 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DHHC PF01529.20 KOO29574.1 - 0.051 13.7 0.1 0.07 13.2 0.1 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase BacteriocIIc_cy PF12173.8 KOO29574.1 - 0.13 12.6 2.0 0.97 9.7 0.1 2.1 2 0 0 2 2 2 0 Bacteriocin class IIc cyclic gassericin A-like TMEMspv1-c74-12 PF11044.8 KOO29574.1 - 0.2 11.7 0.1 0.2 11.7 0.1 2.1 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein ASC PF00858.24 KOO29574.1 - 3.4 6.5 3.8 1.2 8.1 1.4 1.5 1 1 1 2 2 2 0 Amiloride-sensitive sodium channel MatE PF01554.18 KOO29575.1 - 4.7e-23 81.6 26.8 7.2e-17 61.5 7.2 2.4 2 1 0 2 2 2 2 MatE PP2C PF00481.21 KOO29576.1 - 3.6e-43 148.1 0.0 4.5e-43 147.7 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO29576.1 - 7.9e-06 25.6 1.7 0.0004 20.1 1.8 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 KOO29576.1 - 5.1e-05 23.3 0.1 0.004 17.1 0.0 2.4 2 1 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Zip PF02535.22 KOO29577.1 - 2.4e-34 119.0 8.9 2.6e-34 118.9 8.9 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Clp1 PF06807.14 KOO29577.1 - 0.16 12.4 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 Strumpellin PF10266.9 KOO29578.1 - 5e-21 74.2 0.1 1.6e-20 72.6 0.0 1.8 2 0 0 2 2 2 1 Hereditary spastic paraplegia protein strumpellin Histone PF00125.24 KOO29580.1 - 1.7e-18 67.2 0.1 2.1e-18 66.9 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 KOO29580.1 - 8e-15 54.3 0.3 1.5e-14 53.4 0.3 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 KOO29580.1 - 0.086 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RRM_1 PF00076.22 KOO29581.1 - 5.5e-19 67.8 0.1 2.2e-15 56.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOO29581.1 - 1.9e-06 27.9 0.0 2.3e-05 24.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif RRM_Rrp7 PF17799.1 KOO29581.1 - 0.091 12.6 0.0 1.3 8.8 0.0 2.1 1 1 1 2 2 2 0 Rrp7 RRM-like N-terminal domain LRR_9 PF14580.6 KOO29582.1 - 1.8e-15 56.9 0.2 3e-15 56.2 0.2 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KOO29582.1 - 5.5e-09 36.2 7.1 8.3e-05 22.9 0.3 2.8 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO29582.1 - 0.00027 20.6 10.1 0.0032 17.2 5.1 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 KOO29582.1 - 0.0033 17.3 0.3 0.95 9.7 0.2 3.3 3 0 0 3 3 3 1 Leucine Rich repeat Dev_Cell_Death PF10539.9 KOO29583.1 - 8.7e-17 61.2 0.0 9.6e-17 61.0 0.0 1.0 1 0 0 1 1 1 1 Development and cell death domain RlaP PF10127.9 KOO29585.1 - 3.3e-06 26.9 0.2 4.6e-06 26.4 0.2 1.3 1 0 0 1 1 1 1 RNA repair pathway DNA polymerase beta family Polbeta PF18765.1 KOO29585.1 - 0.23 11.6 0.0 0.42 10.7 0.0 1.3 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase EF-hand_1 PF00036.32 KOO29586.1 - 4.1e-39 129.2 1.4 5.5e-05 22.4 0.0 7.5 7 0 0 7 7 7 7 EF hand EF-hand_6 PF13405.6 KOO29586.1 - 9.1e-31 103.1 6.8 0.0011 18.8 0.1 7.7 7 0 0 7 7 7 7 EF-hand domain EF-hand_7 PF13499.6 KOO29586.1 - 1.2e-30 105.8 0.0 4.7e-05 23.8 0.0 7.1 5 1 2 7 7 7 7 EF-hand domain pair EF-hand_5 PF13202.6 KOO29586.1 - 1.2e-27 94.1 6.4 0.00022 20.6 0.0 6.6 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.6 KOO29586.1 - 7.3e-27 93.0 7.7 0.00021 21.0 0.0 8.3 7 1 1 8 8 8 7 EF-hand domain pair EF-hand_4 PF12763.7 KOO29586.1 - 1e-06 28.7 0.1 12 5.9 0.0 6.7 7 1 0 7 7 7 1 Cytoskeletal-regulatory complex EF hand fn3 PF00041.21 KOO29586.1 - 9.9e-06 25.8 0.0 2.1e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain TcdB_toxin_midN PF12256.8 KOO29586.1 - 0.014 14.7 0.1 0.068 12.5 0.0 2.2 3 0 0 3 3 3 0 Insecticide toxin TcdB middle/N-terminal region EF-hand_9 PF14658.6 KOO29586.1 - 0.016 15.5 0.4 11 6.5 0.0 4.8 7 0 0 7 7 7 0 EF-hand domain EF-hand_10 PF14788.6 KOO29586.1 - 0.13 12.1 3.5 10 6.1 0.2 5.0 8 0 0 8 8 8 0 EF hand DUF3545 PF12065.8 KOO29586.1 - 0.18 11.9 0.0 0.47 10.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3545) VCBS PF13517.6 KOO29586.1 - 0.87 10.2 6.9 2.2 8.9 0.3 3.8 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TMF_TATA_bd PF12325.8 KOO29587.1 - 0.0014 18.8 13.8 0.093 13.0 0.6 3.1 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding Filament PF00038.21 KOO29587.1 - 0.0072 15.9 11.9 0.017 14.7 11.6 1.8 1 1 0 1 1 1 1 Intermediate filament protein Cep57_CLD PF14073.6 KOO29587.1 - 0.0076 16.3 12.2 0.012 15.7 12.2 1.3 1 1 0 1 1 1 1 Centrosome localisation domain of Cep57 SHE3 PF17078.5 KOO29587.1 - 0.026 14.3 3.6 0.81 9.4 1.1 2.1 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 bZIP_1 PF00170.21 KOO29587.1 - 0.065 13.3 6.5 1.3 9.2 0.3 3.4 3 1 0 3 3 3 0 bZIP transcription factor Cep57_MT_bd PF06657.13 KOO29587.1 - 0.13 12.7 8.5 0.91 10.0 0.4 2.7 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Rho_Binding PF08912.11 KOO29587.1 - 0.22 12.4 10.8 0.45 11.4 0.4 3.1 1 1 2 3 3 3 0 Rho Binding TolA_bind_tri PF16331.5 KOO29587.1 - 0.48 10.5 9.6 0.1 12.7 2.1 2.8 3 1 0 3 3 3 0 TolA binding protein trimerisation ZapB PF06005.12 KOO29587.1 - 0.56 10.7 12.7 2.4 8.6 2.5 2.9 2 1 0 2 2 2 0 Cell division protein ZapB Spc7 PF08317.11 KOO29587.1 - 0.67 8.8 14.6 0.59 9.0 8.0 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4407 PF14362.6 KOO29587.1 - 0.91 8.8 20.5 3.6 6.9 20.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4201 PF13870.6 KOO29587.1 - 0.95 9.2 9.0 4.6 6.9 0.3 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) DUF4472 PF14739.6 KOO29587.1 - 1.4 9.7 12.6 9.5 7.0 5.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) DUF4054 PF13262.6 KOO29587.1 - 1.4 9.0 8.3 0.6 10.2 0.9 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF4054) Ax_dynein_light PF10211.9 KOO29587.1 - 1.4 8.8 10.1 0.44 10.5 0.4 2.5 1 1 0 2 2 2 0 Axonemal dynein light chain HALZ PF02183.18 KOO29587.1 - 1.5 9.1 8.6 12 6.2 0.9 3.7 4 0 0 4 4 3 0 Homeobox associated leucine zipper CENP-H PF05837.12 KOO29587.1 - 1.7 9.1 15.7 6.3 7.2 6.1 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) NPV_P10 PF05531.12 KOO29587.1 - 2 8.9 4.3 14 6.2 1.5 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Golgin_A5 PF09787.9 KOO29587.1 - 2.4 7.6 11.9 1.8 8.0 6.2 1.8 1 1 1 2 2 2 0 Golgin subfamily A member 5 Spc24 PF08286.11 KOO29587.1 - 3.4 8.0 13.8 24 5.2 5.5 2.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Nup54 PF13874.6 KOO29587.1 - 5 7.2 14.5 8.7e+02 -0.0 14.5 2.4 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 DUF3641 PF12345.8 KOO29588.1 - 7e-48 162.1 0.0 1.2e-47 161.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3641) Radical_SAM PF04055.21 KOO29588.1 - 2e-09 38.0 0.0 6.4e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 KOO29588.1 - 0.0017 18.6 0.0 0.0032 17.8 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Methyltransf_11 PF08241.12 KOO29589.1 - 6.7e-12 45.9 0.0 1.1e-11 45.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO29589.1 - 3.2e-07 31.0 0.0 6.1e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO29589.1 - 8.3e-06 25.3 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 KOO29589.1 - 3.7e-05 24.4 0.0 6.6e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO29589.1 - 4e-05 23.5 0.0 5.8e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO29589.1 - 7.9e-05 22.5 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 KOO29589.1 - 8.2e-05 21.3 0.0 0.00011 21.0 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 KOO29589.1 - 0.018 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 KOO29589.1 - 0.06 13.2 0.0 0.085 12.7 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase HRDC PF00570.23 KOO29590.1 - 1.1e-16 60.6 1.4 1.6e-16 60.0 0.2 1.8 2 0 0 2 2 2 1 HRDC domain QRPTase_N PF02749.16 KOO29590.1 - 0.092 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, N-terminal domain TylF PF05711.11 KOO29591.1 - 6.6e-47 160.0 0.0 9.6e-47 159.4 0.0 1.2 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) PPR_2 PF13041.6 KOO29591.1 - 8.2e-26 90.0 0.0 1e-11 44.8 0.1 4.4 3 1 1 4 4 4 4 PPR repeat family PPR_3 PF13812.6 KOO29591.1 - 1.9e-12 47.0 0.0 6.4e-09 35.8 0.0 3.3 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR PF01535.20 KOO29591.1 - 1.1e-11 44.1 0.5 0.0023 18.0 0.0 4.7 5 0 0 5 5 5 3 PPR repeat PPR_1 PF12854.7 KOO29591.1 - 7.9e-10 38.3 0.8 0.02 14.6 0.0 4.7 6 0 0 6 6 6 3 PPR repeat PPR_long PF17177.4 KOO29591.1 - 1.4e-08 34.4 0.1 4.5e-06 26.2 0.0 2.4 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP Methyltransf_24 PF13578.6 KOO29591.1 - 6.6e-08 33.5 0.5 2.1e-06 28.7 0.0 3.0 2 1 0 2 2 2 1 Methyltransferase domain Smr PF01713.21 KOO29591.1 - 0.13 12.7 0.0 0.4 11.1 0.0 1.8 1 0 0 1 1 1 0 Smr domain Cullin_binding PF03556.15 KOO29591.1 - 0.18 12.3 0.0 0.53 10.7 0.0 1.8 1 0 0 1 1 1 0 Cullin binding Pkinase PF00069.25 KOO29592.1 - 9.2e-21 74.4 0.0 1.9e-20 73.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29592.1 - 1.1e-19 70.7 0.0 8.5e-19 67.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 KOO29592.1 - 0.021 14.4 0.0 2.2 7.9 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Sugar_transport PF06800.12 KOO29593.1 - 1.4e-13 50.9 18.0 8.9e-11 41.6 0.9 2.7 2 1 1 3 3 3 2 Sugar transport protein TMEM144 PF07857.12 KOO29593.1 - 1.9e-12 46.9 1.1 9.9e-07 28.0 0.3 2.1 2 0 0 2 2 2 2 Transmembrane family, TMEM144 of transporters Multi_Drug_Res PF00893.19 KOO29593.1 - 0.0087 16.7 6.3 0.031 14.9 3.5 3.1 2 1 1 3 3 3 1 Small Multidrug Resistance protein DUF1304 PF06993.12 KOO29593.1 - 0.034 14.1 6.0 3.3 7.8 0.0 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF1304) Sulfotransfer_1 PF00685.27 KOO29594.1 - 1.9e-05 24.3 0.0 8.2e-05 22.2 0.0 1.9 2 1 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KOO29594.1 - 0.00033 21.1 1.7 0.89 9.9 1.0 3.3 2 1 0 2 2 2 1 Sulfotransferase family LRR_6 PF13516.6 KOO29595.1 - 6.6e-25 85.0 17.5 0.00036 20.4 0.0 6.6 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.7 KOO29595.1 - 0.00077 19.8 5.8 2 9.0 0.0 4.7 4 2 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO29595.1 - 0.0064 16.2 3.8 7.9 6.3 0.3 5.0 5 1 1 6 6 6 1 Leucine rich repeat CbiG_N PF11760.8 KOO29595.1 - 0.28 11.2 10.6 18 5.4 1.8 4.3 4 1 0 4 4 4 0 Cobalamin synthesis G N-terminal HOASN PF14515.6 KOO29595.1 - 1.4 9.4 10.1 8.1 6.9 0.1 4.2 1 1 3 4 4 4 0 Haem-oxygenase-associated N-terminal helices LVIVD PF08309.11 KOO29596.1 - 9.9e-52 172.0 43.8 2.6e-11 42.6 1.2 5.3 5 0 0 5 5 5 5 LVIVD repeat Beta_propel PF09826.9 KOO29596.1 - 0.00013 20.9 0.4 3.1 6.5 0.0 4.6 4 1 0 5 5 5 2 Beta propeller domain Chitin_bind_4 PF00379.23 KOO29596.1 - 0.0071 16.8 9.0 29 5.3 0.0 5.2 5 0 0 5 5 5 0 Insect cuticle protein MTTB PF06253.11 KOO29596.1 - 0.011 13.7 0.6 0.72 7.8 0.0 2.2 2 0 0 2 2 2 0 Trimethylamine methyltransferase (MTTB) SBP56 PF05694.11 KOO29596.1 - 0.014 14.3 0.0 13 4.5 0.0 3.8 1 1 3 4 4 4 0 56kDa selenium binding protein (SBP56) PQQ_3 PF13570.6 KOO29596.1 - 0.017 15.6 13.4 13 6.4 0.6 5.4 4 0 0 4 4 4 0 PQQ-like domain Lactonase PF10282.9 KOO29596.1 - 0.067 12.4 2.2 0.89 8.8 0.5 3.0 1 1 2 3 3 3 0 Lactonase, 7-bladed beta-propeller FlpD PF02662.16 KOO29596.1 - 0.19 11.7 0.1 5.2 7.1 0.0 2.4 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit ADH_zinc_N_2 PF13602.6 KOO29598.1 - 1.6e-10 42.1 0.2 1.6e-10 42.1 0.2 1.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PAS_4 PF08448.10 KOO29598.1 - 0.072 13.3 0.0 0.08 13.2 0.0 1.1 1 0 0 1 1 1 0 PAS fold Pyrophosphatase PF00719.19 KOO29599.1 - 2.7e-46 157.3 0.1 3.8e-46 156.8 0.1 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase EF-hand_7 PF13499.6 KOO29599.1 - 4.9e-12 46.1 0.0 1e-11 45.1 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO29599.1 - 2.4e-08 33.2 0.2 0.0018 18.0 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO29599.1 - 3.1e-06 26.3 0.1 0.022 14.3 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO29599.1 - 0.00011 21.9 0.0 0.00046 20.0 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO29599.1 - 0.0054 16.2 0.7 0.06 12.9 0.2 2.4 2 0 0 2 2 2 1 EF hand MobL PF18555.1 KOO29599.1 - 0.14 11.4 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 MobL relaxases PPR_2 PF13041.6 KOO29600.1 - 5.8e-10 39.2 0.0 2.9e-05 24.2 0.0 3.8 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.20 KOO29600.1 - 0.00051 20.1 0.0 0.39 11.1 0.0 3.8 3 0 0 3 3 3 1 PPR repeat PPR_3 PF13812.6 KOO29600.1 - 0.0012 18.9 0.0 0.0046 17.0 0.0 2.0 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 KOO29600.1 - 0.02 14.6 1.9 0.93 9.3 0.0 3.8 4 0 0 4 4 4 0 PPR repeat TPR_14 PF13428.6 KOO29600.1 - 1.8 9.6 9.3 8.6 7.5 0.3 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat Exostosin PF03016.15 KOO29601.1 - 1.1e-06 28.0 0.1 1.9e-06 27.3 0.0 1.6 1 1 1 2 2 2 1 Exostosin family TMEM70 PF06979.12 KOO29602.1 - 5.6e-08 33.3 0.0 7.7e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex HALZ PF02183.18 KOO29603.1 - 1.3 9.4 23.9 9.1 6.6 0.4 7.5 8 0 0 8 8 8 0 Homeobox associated leucine zipper Radical_SAM PF04055.21 KOO29604.1 - 2.9e-22 79.8 0.0 3.6e-10 40.5 0.0 2.4 2 0 0 2 2 2 2 Radical SAM superfamily Pkinase PF00069.25 KOO29605.1 - 3.9e-30 105.1 0.0 5.7e-30 104.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29605.1 - 1.8e-12 47.1 0.0 2.6e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO29605.1 - 0.00071 19.6 5.2 0.048 13.6 0.2 3.1 2 2 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 KOO29605.1 - 0.00088 18.7 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO29605.1 - 0.093 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like BT1 PF03092.16 KOO29607.1 - 2.4e-12 45.9 16.5 2.2e-06 26.2 0.5 3.4 3 1 0 3 3 3 3 BT1 family MFS_1 PF07690.16 KOO29607.1 - 3.8e-05 22.8 4.2 3.8e-05 22.8 4.2 3.5 1 1 1 3 3 3 2 Major Facilitator Superfamily Ank_2 PF12796.7 KOO29608.1 - 3.6e-06 27.5 0.0 0.0035 17.9 0.0 3.9 2 2 1 3 3 3 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO29608.1 - 0.0034 17.8 0.4 13 6.4 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KOO29608.1 - 0.0055 17.1 0.1 11 7.0 0.0 4.4 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.6 KOO29608.1 - 0.13 12.9 0.0 43 4.8 0.0 3.7 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Filamin PF00630.19 KOO29609.1 - 1.6e-19 70.6 0.0 3.3e-08 34.3 0.0 3.2 3 0 0 3 3 3 3 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO29609.1 - 1.7e-06 28.2 1.3 9.8e-06 25.8 0.1 2.5 2 1 1 3 3 3 1 Invasin, domain 3 SH3_3 PF08239.11 KOO29609.1 - 1.1e-05 25.7 0.0 2.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Cadherin_5 PF17892.1 KOO29609.1 - 6.6e-05 22.8 0.0 0.00016 21.6 0.0 1.6 1 0 0 1 1 1 1 Cadherin-like domain Big_1 PF02369.16 KOO29609.1 - 0.14 12.1 2.1 1.1 9.3 0.1 3.4 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 1) SET PF00856.28 KOO29610.1 - 2.9e-22 79.8 0.0 2.3e-21 76.9 0.0 2.3 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 KOO29610.1 - 8.8e-16 58.5 2.0 8.8e-16 58.5 2.0 2.2 2 0 0 2 2 2 1 Pre-SET motif Band_7 PF01145.25 KOO29611.1 - 2e-06 28.0 1.3 4.1e-06 26.9 1.3 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family UQ_con PF00179.26 KOO29613.1 - 1.4e-43 147.9 0.0 1.9e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO29613.1 - 0.00014 21.6 0.0 0.00023 20.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KOO29613.1 - 0.003 17.8 0.0 0.0049 17.1 0.0 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KOO29613.1 - 0.0058 16.5 0.1 0.013 15.4 0.1 1.5 1 1 0 1 1 1 1 UEV domain Ion_trans PF00520.31 KOO29614.1 - 1.5e-20 73.5 5.3 2.6e-20 72.7 5.3 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO29614.1 - 6.1e-06 26.1 6.4 6.1e-06 26.1 6.4 3.2 3 1 1 4 4 4 1 Ion channel SHOCT PF09851.9 KOO29614.1 - 0.0005 19.7 0.2 0.0011 18.6 0.2 1.6 1 0 0 1 1 1 1 Short C-terminal domain IRK PF01007.20 KOO29614.1 - 0.012 15.4 0.1 0.037 13.8 0.1 1.8 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain GvpG PF05120.12 KOO29614.1 - 0.13 12.3 1.1 0.23 11.5 0.5 1.7 2 0 0 2 2 2 0 Gas vesicle protein G Ald_Xan_dh_C2 PF02738.18 KOO29615.1 - 3.4e-95 319.6 0.3 3.4e-95 319.6 0.3 2.2 2 0 0 2 2 2 1 Molybdopterin-binding domain of aldehyde dehydrogenase Fer2_2 PF01799.20 KOO29615.1 - 2.6e-24 85.0 1.1 8.6e-24 83.4 1.1 2.0 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.22 KOO29615.1 - 2.1e-16 60.3 0.7 5.2e-16 59.0 0.7 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain FAD_binding_5 PF00941.21 KOO29615.1 - 4.2e-15 55.9 0.1 1.3e-14 54.4 0.1 1.8 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Fer2 PF00111.27 KOO29615.1 - 8.2e-05 22.5 0.3 8.2e-05 22.5 0.3 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain CO_deh_flav_C PF03450.17 KOO29615.1 - 0.0034 17.5 0.1 0.024 14.8 0.1 2.6 1 1 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain PPR_3 PF13812.6 KOO29616.1 - 2.7e-53 177.9 0.0 8.5e-11 41.8 0.0 7.4 4 3 4 8 8 8 8 Pentatricopeptide repeat domain PPR_2 PF13041.6 KOO29616.1 - 4.6e-50 167.6 0.0 1.6e-07 31.4 0.0 9.2 3 3 7 10 10 10 10 PPR repeat family PPR PF01535.20 KOO29616.1 - 1.4e-39 131.6 7.6 0.00066 19.8 0.1 12.3 13 0 0 13 13 13 9 PPR repeat PPR_long PF17177.4 KOO29616.1 - 3.3e-37 127.9 0.0 3.6e-12 46.1 0.0 4.1 1 1 3 4 4 4 4 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 KOO29616.1 - 7e-28 96.0 0.0 9.7e-05 22.0 0.0 10.8 11 0 0 11 11 11 6 PPR repeat PDZ PF00595.24 KOO29616.1 - 0.032 14.6 0.1 0.072 13.5 0.1 1.5 1 0 0 1 1 1 0 PDZ domain TPR_19 PF14559.6 KOO29616.1 - 0.088 13.3 4.7 1.5 9.4 0.1 4.1 3 1 0 4 4 4 0 Tetratricopeptide repeat RRM_1 PF00076.22 KOO29617.1 - 1.2e-18 66.7 0.1 2e-18 66.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.6 KOO29617.1 - 1.8e-09 37.9 0.0 5.8e-09 36.3 0.0 1.7 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_occluded PF16842.5 KOO29617.1 - 0.029 14.2 0.0 0.087 12.7 0.0 1.8 2 1 0 2 2 2 0 Occluded RNA-recognition motif HAD_SAK_2 PF18143.1 KOO29618.1 - 8.9e-05 22.8 0.0 0.00012 22.4 0.0 1.2 1 0 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins Na_H_Exchanger PF00999.21 KOO29619.1 - 9.9e-56 189.2 30.6 1.2e-55 188.8 30.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family MHYT PF03707.16 KOO29619.1 - 1.6 9.0 8.7 0.23 11.7 0.7 3.5 3 0 0 3 3 3 0 Bacterial signalling protein N terminal repeat zf-CCHC PF00098.23 KOO29621.1 - 0.012 15.6 2.0 0.022 14.9 2.0 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 KOO29621.1 - 0.11 12.4 0.6 0.23 11.3 0.6 1.5 1 0 0 1 1 1 0 Zinc knuckle RVT_2 PF07727.14 KOO29622.1 - 1e-22 81.0 0.0 1.5e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Nucleotid_trans PF03407.16 KOO29623.1 - 4.6e-22 79.1 0.0 6.4e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Anoctamin PF04547.12 KOO29624.1 - 5e-98 328.9 7.8 6.1e-98 328.6 7.8 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KOO29624.1 - 0.00027 20.8 0.0 0.052 13.3 0.0 2.2 1 1 1 2 2 2 2 Dimerisation domain of Ca+-activated chloride-channel, anoctamin ART PF01129.18 KOO29625.1 - 2.5e-05 23.7 0.0 0.00024 20.5 0.0 2.1 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO29625.1 - 0.00054 19.4 0.0 0.001 18.5 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme PHD20L1_u1 PF16660.5 KOO29628.1 - 0.14 12.9 0.9 0.14 12.9 0.9 2.1 2 1 0 2 2 2 0 PHD finger protein 20-like protein 1 Radical_SAM PF04055.21 KOO29629.1 - 3.1e-05 24.4 0.0 6e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Radical SAM superfamily DUF2608 PF11019.8 KOO29630.1 - 0.00025 20.7 0.0 0.00032 20.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2608) Tetraspanin PF00335.20 KOO29631.1 - 7.9e-05 22.5 5.1 7.9e-05 22.5 5.1 2.0 2 0 0 2 2 2 1 Tetraspanin family DEAD PF00270.29 KOO29633.1 - 7.1e-48 162.7 0.0 1.1e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO29633.1 - 3.3e-25 88.6 0.0 7.5e-25 87.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO29633.1 - 0.00047 20.2 0.0 0.0009 19.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOO29633.1 - 0.0015 17.8 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.14 KOO29633.1 - 0.016 14.5 0.0 0.036 13.4 0.0 1.5 1 1 0 1 1 1 0 SecA DEAD-like domain AAA_22 PF13401.6 KOO29633.1 - 0.037 14.3 0.1 0.18 12.1 0.1 2.2 1 1 0 1 1 1 0 AAA domain SWI2_SNF2 PF18766.1 KOO29633.1 - 0.078 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 SWI2/SNF2 ATPase HMMR_C PF15908.5 KOO29634.1 - 0.0024 18.1 1.9 0.0042 17.4 1.7 1.4 1 1 0 1 1 1 1 Hyaluronan mediated motility receptor C-terminal KASH_CCD PF14662.6 KOO29634.1 - 0.0056 16.5 7.4 0.0081 16.0 7.4 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH BRE1 PF08647.11 KOO29634.1 - 0.015 15.3 8.2 0.015 15.3 8.2 2.1 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase TMCO5 PF14992.6 KOO29634.1 - 0.062 12.9 2.6 0.076 12.6 2.6 1.1 1 0 0 1 1 1 0 TMCO5 family ATG16 PF08614.11 KOO29634.1 - 0.17 12.1 22.0 0.25 11.5 22.0 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) FAM76 PF16046.5 KOO29634.1 - 2.9 7.2 7.0 3.7 6.8 7.0 1.1 1 0 0 1 1 1 0 FAM76 protein Seryl_tRNA_N PF02403.22 KOO29634.1 - 4.7 7.5 9.6 4.7 7.5 8.1 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.9 KOO29634.1 - 6.8 5.7 15.7 8.9 5.3 15.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Lzipper-MIP1 PF14389.6 KOO29634.1 - 7.1 7.0 10.8 0.94 9.8 3.4 2.8 3 1 1 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 Spc24 PF08286.11 KOO29634.1 - 7.6 6.8 6.5 6.3 7.1 4.2 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 AAA_13 PF13166.6 KOO29634.1 - 9 4.8 10.2 13 4.3 10.2 1.1 1 0 0 1 1 1 0 AAA domain TFIIA PF03153.13 KOO29634.1 - 9.6 6.1 10.2 12 5.8 10.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PP2C PF00481.21 KOO29635.1 - 2.2e-27 96.3 0.6 4.3e-13 49.5 0.1 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 KOO29635.1 - 0.01 15.7 0.0 0.034 14.1 0.0 1.7 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) DMRT-like PF15791.5 KOO29635.1 - 2.9 8.3 5.6 7.2 7.1 0.6 3.1 3 0 0 3 3 3 0 Doublesex-and mab-3-related transcription factor C1 and C2 DUF1995 PF09353.10 KOO29636.1 - 1.9e-18 67.2 0.0 2.6e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) SIR2 PF02146.17 KOO29637.1 - 4.4e-49 166.8 0.0 5.4e-49 166.5 0.0 1.1 1 0 0 1 1 1 1 Sir2 family Cwf_Cwc_15 PF04889.12 KOO29637.1 - 0.16 11.7 12.3 0.24 11.1 12.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 KOO29637.1 - 3.7 5.5 17.7 5.1 5.1 17.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi TPT PF03151.16 KOO29638.1 - 2.2e-74 250.4 14.9 2.5e-74 250.2 14.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO29638.1 - 1.1e-07 32.1 23.4 2.8e-05 24.3 8.8 2.7 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO29638.1 - 0.00038 19.8 9.1 0.0021 17.3 9.1 2.0 1 1 0 1 1 1 1 UAA transporter family Ycf66_N PF07444.11 KOO29638.1 - 0.071 13.3 5.4 1.1 9.5 0.1 3.7 4 0 0 4 4 4 0 Ycf66 protein N-terminus WD40 PF00400.32 KOO29639.1 - 0.13 13.2 0.2 11 7.1 0.0 3.1 3 0 0 3 3 3 0 WD domain, G-beta repeat Mito_fiss_reg PF05308.11 KOO29639.1 - 0.71 9.9 4.0 0.98 9.4 4.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 KOO29639.1 - 7.6 5.9 8.1 11 5.4 8.1 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal FKBP_C PF00254.28 KOO29640.1 - 1.1e-29 102.6 0.0 1.6e-29 102.1 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase AhpC-TSA_2 PF13911.6 KOO29641.1 - 0.00062 19.9 0.0 0.00081 19.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DnaJ_C PF01556.18 KOO29642.1 - 0.16 12.0 0.0 7.7 6.6 0.0 2.5 1 1 1 2 2 2 0 DnaJ C terminal domain LRR_6 PF13516.6 KOO29643.1 - 1.2e-28 96.7 13.0 6.2e-06 25.9 0.0 7.4 7 0 0 7 7 7 5 Leucine Rich repeat LRR_1 PF00560.33 KOO29643.1 - 0.00066 19.9 0.0 46 5.1 0.0 6.0 7 0 0 7 7 7 0 Leucine Rich Repeat CbiG_N PF11760.8 KOO29643.1 - 0.0012 18.8 9.7 1.5 8.9 0.2 4.2 4 0 0 4 4 4 3 Cobalamin synthesis G N-terminal LRR_4 PF12799.7 KOO29643.1 - 0.0079 16.6 13.1 4.2 7.9 0.3 5.7 2 2 4 6 6 6 3 Leucine Rich repeats (2 copies) HOASN PF14515.6 KOO29643.1 - 0.0086 16.4 11.3 9.6 6.7 0.1 5.1 2 1 3 5 5 5 3 Haem-oxygenase-associated N-terminal helices CoatB PF10389.9 KOO29643.1 - 0.0087 15.9 5.6 2.2 8.2 0.3 3.8 3 1 1 4 4 4 2 Bacteriophage coat protein B SpoU_sub_bind PF08032.12 KOO29643.1 - 0.069 13.4 1.6 1.7 9.0 0.2 3.2 4 1 0 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding YusW PF14039.6 KOO29643.1 - 0.19 12.3 2.1 16 6.1 0.1 3.3 2 1 2 4 4 4 0 YusW-like protein RACo_linker PF17650.1 KOO29644.1 - 0.61 10.0 3.0 12 5.8 0.2 2.7 1 1 1 2 2 2 0 RACo linker region DUF4014 PF13198.6 KOO29644.1 - 2.4 8.6 4.2 66 4.0 0.1 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF4014) LRR_6 PF13516.6 KOO29645.1 - 0.0028 17.6 0.0 0.006 16.5 0.0 1.5 1 0 0 1 1 1 1 Leucine Rich repeat EMP70 PF02990.16 KOO29646.1 - 1.6e-223 743.1 4.8 1.6e-223 743.1 4.8 1.4 2 0 0 2 2 2 1 Endomembrane protein 70 Acetyltransf_6 PF13480.7 KOO29648.1 - 0.034 14.3 0.2 0.065 13.4 0.1 1.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO29649.1 - 4.9e-09 36.4 0.0 9e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO29649.1 - 7.5e-06 26.3 0.0 3.2e-05 24.3 0.0 2.0 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO29649.1 - 9.4e-06 25.6 0.0 1.6e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF1707 PF08044.11 KOO29649.1 - 0.08 13.0 1.0 1.2 9.3 0.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1707) AAA_16 PF13191.6 KOO29650.1 - 9e-05 22.9 5.0 0.0001 22.8 0.2 2.9 2 1 0 2 2 2 1 AAA ATPase domain APS_kinase PF01583.20 KOO29650.1 - 0.036 14.0 0.0 0.08 12.8 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA PF00004.29 KOO29650.1 - 0.086 13.3 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 KOO29650.1 - 0.09 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 KOO29650.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CPT PF07931.12 KOO29650.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.6 KOO29650.1 - 0.16 12.3 0.0 0.48 10.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO29650.1 - 0.17 11.6 0.0 0.4 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain EF-hand_7 PF13499.6 KOO29651.1 - 5.4e-14 52.4 0.9 1.2e-13 51.3 0.4 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO29651.1 - 4.3e-12 44.7 4.1 2.9e-06 26.4 0.2 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO29651.1 - 1.3e-11 43.4 2.4 0.00037 20.2 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO29651.1 - 8.4e-09 35.1 1.0 2e-08 34.0 0.6 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO29651.1 - 1.5e-08 33.8 4.6 0.0021 17.4 0.0 3.1 4 0 0 4 4 4 2 EF hand WW PF00397.26 KOO29652.1 - 0.0035 17.4 6.8 0.051 13.7 1.0 3.2 3 0 0 3 3 3 2 WW domain Kinesin PF00225.23 KOO29654.1 - 1.2e-54 185.5 0.0 2.8e-54 184.3 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO29654.1 - 5.9e-20 71.7 0.0 1e-19 71.0 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Taxilin PF09728.9 KOO29654.1 - 0.00035 19.9 3.4 0.00035 19.9 3.4 1.9 2 0 0 2 2 2 1 Myosin-like coiled-coil protein Atg14 PF10186.9 KOO29654.1 - 0.00044 19.4 13.0 0.00044 19.4 13.0 1.6 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 KOO29654.1 - 0.15 10.9 29.8 0.036 13.0 12.6 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Kre28 PF17097.5 KOO29654.1 - 0.23 10.4 3.3 0.4 9.6 3.3 1.3 1 0 0 1 1 1 0 Spindle pole body component DUF4201 PF13870.6 KOO29654.1 - 1.6 8.5 12.1 0.19 11.4 4.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF1515 PF07439.11 KOO29654.1 - 2.8 8.0 6.2 0.7 9.9 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) HAP1_N PF04849.13 KOO29654.1 - 8.5 5.5 21.5 16 4.5 4.7 2.1 1 1 1 2 2 2 0 HAP1 N-terminal conserved region ATG16 PF08614.11 KOO29654.1 - 8.8 6.5 38.7 6.5 6.9 15.8 2.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Ncstrn_small PF18266.1 KOO29656.1 - 7.4e-22 78.1 0.0 1e-21 77.7 0.0 1.2 1 0 0 1 1 1 1 Nicastrin small lobe Nicastrin PF05450.15 KOO29656.1 - 2e-21 76.5 0.0 2.8e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Nicastrin Sulfatase PF00884.23 KOO29657.1 - 3e-50 171.4 0.0 2.4e-49 168.4 0.0 2.0 1 1 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KOO29657.1 - 4.5e-05 24.2 0.0 0.00016 22.4 0.0 1.9 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphoesterase PF04185.14 KOO29657.1 - 0.077 12.2 0.0 1.8 7.7 0.0 2.2 2 0 0 2 2 2 0 Phosphoesterase family Aha1_N PF09229.11 KOO29658.1 - 1e-29 103.5 2.8 1e-29 103.5 1.6 1.6 2 0 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 KOO29658.1 - 3e-18 66.3 0.0 7e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein WD40 PF00400.32 KOO29659.1 - 8.9e-22 77.0 15.3 2.9e-06 27.9 0.2 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO29659.1 - 3.4e-17 62.5 3.7 1.7e-05 25.0 0.3 4.2 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO29659.1 - 1.5e-06 28.3 0.1 0.61 9.9 0.0 2.9 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOO29659.1 - 0.037 13.0 0.3 0.33 9.9 0.0 2.3 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Abhydrolase_1 PF00561.20 KOO29660.1 - 3.1e-12 46.7 0.0 8e-11 42.1 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 KOO29660.1 - 4.1e-08 33.3 0.0 2.5e-07 30.7 0.0 2.1 1 1 0 1 1 1 1 TAP-like protein Hydrolase_4 PF12146.8 KOO29660.1 - 0.07 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 SbcD_C PF12320.8 KOO29661.1 - 0.011 16.0 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain mTERF PF02536.14 KOO29662.1 - 9.6e-24 83.9 0.0 1.1e-17 64.0 0.0 2.5 1 1 1 2 2 2 2 mTERF Acyl_transf_3 PF01757.22 KOO29662.1 - 5.7e-09 35.5 2.6 8.3e-09 35.0 2.6 1.2 1 0 0 1 1 1 1 Acyltransferase family Pkinase PF00069.25 KOO29663.1 - 1.1e-68 231.5 0.0 4e-68 229.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29663.1 - 3.1e-34 118.4 0.0 3.6e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO29663.1 - 0.00015 20.8 0.0 0.0025 16.8 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KOO29663.1 - 0.0028 17.3 0.0 0.0039 16.8 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KOO29663.1 - 0.0033 17.4 0.1 0.0045 16.9 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO29663.1 - 0.0061 15.9 0.0 0.024 13.9 0.0 1.9 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 KOO29663.1 - 0.087 12.2 0.2 0.23 10.8 0.2 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KOO29663.1 - 0.098 11.7 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 AA_permease_2 PF13520.6 KOO29665.1 - 3.5e-25 88.7 20.0 1.5e-24 86.6 20.0 1.8 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOO29665.1 - 3.5e-07 29.2 12.6 3.5e-07 29.2 12.6 1.8 2 1 0 2 2 2 1 Amino acid permease Homeodomain PF00046.29 KOO29666.1 - 1.7e-17 63.0 0.5 3.5e-17 62.0 0.5 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOO29666.1 - 0.00024 20.9 0.6 0.00064 19.6 0.6 1.7 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 KOO29666.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Sugar_tr PF00083.24 KOO29668.1 - 5.6e-86 289.2 13.7 6.6e-86 289.0 13.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO29668.1 - 9.5e-24 84.0 58.3 2.1e-19 69.7 28.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily PP2C PF00481.21 KOO29669.1 - 3.7e-27 95.6 0.0 5.1e-27 95.1 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO29669.1 - 0.035 13.7 0.6 0.26 10.9 0.6 2.0 1 1 0 1 1 1 0 Protein phosphatase 2C DUF45 PF01863.17 KOO29670.1 - 0.33 11.0 12.1 0.49 10.4 12.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 Nairo_nucleo PF02477.15 KOO29670.1 - 0.55 9.0 4.7 0.68 8.7 4.0 1.3 1 1 0 1 1 1 0 Nucleocapsid N protein Fis1_TPR_C PF14853.6 KOO29670.1 - 5.6 7.1 9.4 4 7.6 1.2 3.2 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat RCC1 PF00415.18 KOO29671.1 - 9.9e-54 179.8 29.6 8.6e-12 45.5 0.4 7.4 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO29671.1 - 3.8e-29 99.9 35.8 2.2e-07 30.5 0.7 6.8 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Filamin PF00630.19 KOO29671.1 - 2.5e-05 25.0 0.0 0.0076 17.1 0.0 3.1 2 1 0 2 2 2 1 Filamin/ABP280 repeat EDR1 PF14381.6 KOO29671.1 - 0.019 14.7 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 Glyco_hydro2_C5 PF18565.1 KOO29671.1 - 0.049 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 EF-hand_1 PF00036.32 KOO29672.1 - 1.4e-57 187.0 12.9 9.4e-07 28.0 1.4 11.2 11 0 0 11 11 11 10 EF hand EF-hand_6 PF13405.6 KOO29672.1 - 2.4e-55 179.8 12.8 2.3e-06 27.1 1.2 10.9 11 0 0 11 11 11 10 EF-hand domain EF-hand_7 PF13499.6 KOO29672.1 - 3.5e-51 171.5 7.2 4.5e-10 39.8 0.9 7.6 5 2 2 7 7 7 7 EF-hand domain pair EF-hand_5 PF13202.6 KOO29672.1 - 6.5e-38 126.6 24.8 7.7e-07 28.3 2.2 11.6 11 0 0 11 11 11 10 EF hand EF-hand_8 PF13833.6 KOO29672.1 - 2.4e-34 117.0 16.4 0.00031 20.5 2.0 10.2 6 4 4 10 10 10 9 EF-hand domain pair EF-hand_9 PF14658.6 KOO29672.1 - 4.7e-07 30.0 0.0 3.6 8.0 0.0 7.3 7 1 0 7 7 7 1 EF-hand domain EF-hand_10 PF14788.6 KOO29672.1 - 0.00023 21.0 1.9 29 4.6 0.0 6.2 7 1 1 8 8 8 0 EF hand EF-hand_4 PF12763.7 KOO29672.1 - 0.0096 15.9 7.7 8 6.5 0.0 6.3 6 1 1 7 7 7 1 Cytoskeletal-regulatory complex EF hand GPHH PF16905.5 KOO29672.1 - 0.016 14.9 0.0 2.6 7.9 0.0 4.1 4 0 0 4 4 4 0 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_14 PF17959.1 KOO29672.1 - 0.02 15.2 2.8 16 5.9 0.0 4.8 4 1 0 4 4 4 0 EF-hand domain Caleosin PF05042.13 KOO29672.1 - 0.3 11.0 2.3 76 3.2 0.1 4.9 4 2 2 6 6 6 0 Caleosin related protein OrfB_IS605 PF01385.19 KOO29672.1 - 2.3 8.5 5.6 0.6 10.4 0.9 2.4 2 0 0 2 2 2 0 Probable transposase Asp_Arg_Hydrox PF05118.15 KOO29673.1 - 1e-42 145.6 0.0 9.1e-42 142.5 0.0 2.0 2 0 0 2 2 2 1 Aspartyl/Asparaginyl beta-hydroxylase ELM2 PF01448.24 KOO29673.1 - 0.069 13.9 0.7 4.4 8.1 0.0 2.6 2 1 0 2 2 2 0 ELM2 domain FTCD_N PF07837.12 KOO29674.1 - 1.6e-24 86.7 0.2 7.4e-24 84.5 0.0 1.9 2 0 0 2 2 2 1 Formiminotransferase domain, N-terminal subdomain Rad21_Rec8_N PF04825.13 KOO29675.1 - 2.3e-33 114.7 0.0 5.7e-33 113.4 0.0 1.6 2 0 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 KOO29675.1 - 8.7e-09 34.5 0.0 8.2e-06 25.0 0.0 2.4 2 0 0 2 2 2 2 Conserved region of Rad21 / Rec8 like protein GUN4 PF05419.12 KOO29676.1 - 0.0085 16.2 0.7 0.014 15.5 0.7 1.3 1 1 0 1 1 1 1 GUN4-like Ribosomal_L13e PF01294.18 KOO29678.1 - 4.4e-08 33.2 15.8 0.44 10.4 0.0 7.9 3 2 3 7 7 7 3 Ribosomal protein L13e MerR_1 PF13411.6 KOO29678.1 - 3.5e-07 30.2 0.0 8.7 6.5 0.0 8.3 6 2 3 10 10 10 1 MerR HTH family regulatory protein TFIID_30kDa PF03540.13 KOO29678.1 - 0.00066 19.6 1.6 1.6e+02 2.3 0.0 7.7 8 2 0 8 8 8 0 Transcription initiation factor TFIID 23-30kDa subunit ART-PolyVal PF18760.1 KOO29678.1 - 0.0032 18.5 0.0 0.21 12.6 0.0 2.8 1 1 0 1 1 1 1 ADP-Ribosyltransferase in polyvalent proteins Maf_N PF08383.11 KOO29678.1 - 0.0044 16.8 14.5 1.1e+02 2.7 0.0 10.7 14 4 3 17 17 17 0 Maf N-terminal region RraB PF06877.11 KOO29678.1 - 0.011 16.5 0.1 21 5.9 0.0 4.2 3 1 1 4 4 4 0 Regulator of ribonuclease activity B PARP PF00644.20 KOO29678.1 - 0.016 14.8 0.4 0.53 9.8 0.0 2.5 1 1 1 2 2 2 0 Poly(ADP-ribose) polymerase catalytic domain RPAP1_C PF08620.10 KOO29678.1 - 0.083 13.0 8.6 27 5.0 0.0 7.0 6 4 3 9 9 9 0 RPAP1-like, C-terminal Peripla_BP_3 PF13377.6 KOO29678.1 - 0.094 13.0 9.0 12 6.1 1.3 4.3 1 1 3 4 4 4 0 Periplasmic binding protein-like domain PTH2 PF01981.16 KOO29678.1 - 0.75 10.1 2.8 30 4.9 1.3 3.0 1 1 1 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 Hydrophob_seed PF14547.6 KOO29678.1 - 1.7 8.9 12.7 1.4e+02 2.8 0.1 5.7 4 1 0 5 5 5 0 Hydrophobic seed protein 17kDa_Anti_2 PF16998.5 KOO29678.1 - 1.8 8.5 8.3 1.6 8.7 0.2 3.7 1 1 2 3 3 3 0 17 kDa outer membrane surface antigen Pyr_redox_dim PF02852.22 KOO29678.1 - 3.3 8.0 12.2 17 5.7 0.6 5.3 3 2 3 6 6 5 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain DUF3849 PF12960.7 KOO29678.1 - 6.2 6.8 14.6 28 4.7 0.0 5.0 1 1 3 5 5 5 0 Protein of unknown function (DUF3849) Rieske PF00355.26 KOO29679.1 - 2.4e-17 62.6 0.0 3.3e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 KOO29679.1 - 3.3e-13 49.5 0.0 4.6e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain RRM_1 PF00076.22 KOO29680.1 - 1e-17 63.7 0.0 1.5e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 KOO29680.1 - 5.3e-06 26.9 3.6 5.3e-06 26.9 3.6 4.1 2 2 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 KOO29680.1 - 0.016 15.1 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_8 PF11835.8 KOO29680.1 - 0.087 13.0 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 RRM-like domain ZapB PF06005.12 KOO29681.1 - 0.087 13.3 19.0 19 5.8 0.1 4.4 3 1 0 3 3 3 0 Cell division protein ZapB YabA PF06156.13 KOO29681.1 - 0.21 12.3 13.6 1.7 9.3 1.8 3.8 3 1 1 4 4 4 0 Initiation control protein YabA KASH_CCD PF14662.6 KOO29681.1 - 1.3 8.8 18.2 0.22 11.4 10.4 3.1 3 1 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH Ino80_Iec3 PF14612.6 KOO29681.1 - 1.9 9.1 7.4 3.8 8.1 7.4 1.5 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling Atg14 PF10186.9 KOO29681.1 - 2.2 7.3 14.8 0.11 11.5 7.6 2.3 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 WD40 PF00400.32 KOO29682.1 - 5e-14 52.5 11.9 0.0081 17.0 0.0 6.0 4 2 2 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO29682.1 - 0.00012 22.3 0.1 0.86 9.9 0.0 3.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Replic_Relax PF13814.6 KOO29682.1 - 0.015 15.4 0.1 0.024 14.7 0.1 1.3 1 0 0 1 1 1 0 Replication-relaxation CHU_C PF13585.6 KOO29682.1 - 0.23 11.5 0.0 0.4 10.8 0.0 1.3 1 0 0 1 1 1 0 C-terminal domain of CHU protein family DUF3611 PF12263.8 KOO29683.1 - 7e-40 136.8 8.3 8.3e-40 136.6 8.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3611) DUF3040 PF11239.8 KOO29683.1 - 4.6 7.6 9.4 2.5 8.4 0.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) Ribosomal_L19e PF01280.20 KOO29684.1 - 9.6e-64 213.8 12.0 9.6e-64 213.8 12.0 1.3 2 0 0 2 2 2 1 Ribosomal protein L19e ATP-synt_C PF00137.21 KOO29685.1 - 2.6e-30 104.5 33.5 3.2e-17 62.6 11.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C TadF PF16964.5 KOO29685.1 - 0.21 11.3 1.5 0.31 10.8 1.5 1.2 1 0 0 1 1 1 0 Putative tight adherence pilin protein F SLATT_5 PF18160.1 KOO29685.1 - 0.27 10.5 1.8 0.41 9.9 0.0 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 CCDC23 PF15674.5 KOO29688.1 - 9.5e-05 22.3 10.0 0.0001 22.2 8.4 2.0 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 23 PGBA_C PF15437.6 KOO29688.1 - 1 9.8 6.8 3.5 8.1 6.8 1.9 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal Glycos_trans_3N PF02885.17 KOO29689.1 - 0.082 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain DUF179 PF02622.15 KOO29690.1 - 1.4e-13 51.1 0.0 1.5e-12 47.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 Ribosomal_L7Ae PF01248.26 KOO29690.1 - 5.8e-09 35.6 0.8 1.6e-07 30.9 0.8 2.3 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family AAA_lid_5 PF17865.1 KOO29690.1 - 0.14 12.2 0.5 0.95 9.6 0.1 2.2 1 1 1 2 2 2 0 Midasin AAA lid domain Peptidase_C12 PF01088.21 KOO29691.1 - 2.4e-50 171.2 0.0 2.9e-50 171.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 T2SSC PF11356.8 KOO29691.1 - 0.1 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Type II secretion system protein C Glyco_transf_25 PF01755.17 KOO29692.1 - 1.9e-10 41.0 0.0 9e-09 35.5 0.0 2.7 1 1 1 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) CAP_N PF01213.19 KOO29692.1 - 0.59 9.6 2.9 0.89 9.0 2.9 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF3584 PF12128.8 KOO29693.1 - 5.6 4.3 13.8 6.8 4.1 13.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) PRP1_N PF06424.12 KOO29694.1 - 0.014 15.8 0.6 0.35 11.2 0.0 2.4 2 1 0 2 2 2 0 PRP1 splicing factor, N-terminal DUF4805 PF16063.5 KOO29694.1 - 0.034 13.5 0.9 0.049 13.0 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4805) MBF1 PF08523.10 KOO29694.1 - 0.052 14.0 2.2 0.052 14.0 2.2 2.5 3 0 0 3 3 3 0 Multiprotein bridging factor 1 SR-25 PF10500.9 KOO29694.1 - 0.14 11.7 5.4 0.12 12.0 3.0 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SAP PF02037.27 KOO29695.1 - 5.9e-10 38.7 0.3 1.8e-09 37.1 0.4 1.8 2 0 0 2 2 2 1 SAP domain HeH PF12949.7 KOO29695.1 - 0.0003 20.4 0.3 0.0021 17.7 0.2 2.2 2 0 0 2 2 2 1 HeH/LEM domain BRCT PF00533.26 KOO29695.1 - 0.0014 19.0 0.0 0.0024 18.2 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KOO29695.1 - 0.034 14.1 0.0 0.11 12.4 0.0 1.9 1 1 0 1 1 1 0 twin BRCT domain MYCBPAP PF14646.6 KOO29695.1 - 0.15 11.0 0.7 0.21 10.5 0.7 1.1 1 0 0 1 1 1 0 MYCBP-associated protein family THOC2_N PF16134.5 KOO29695.1 - 0.17 10.5 0.6 0.22 10.1 0.6 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Myc_N PF01056.18 KOO29695.1 - 0.18 11.7 1.5 0.24 11.3 1.5 1.2 1 0 0 1 1 1 0 Myc amino-terminal region PRP38_assoc PF12871.7 KOO29695.1 - 2.7 8.7 9.9 24 5.6 7.9 2.4 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term PARP PF00644.20 KOO29696.1 - 2.1e-60 203.7 0.0 3.5e-60 202.9 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 KOO29696.1 - 7.1e-29 100.6 0.1 1.2e-28 99.9 0.1 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain CHAT PF12770.7 KOO29696.1 - 0.0004 19.9 2.0 0.00062 19.3 2.0 1.2 1 0 0 1 1 1 1 CHAT domain PRT_C PF08372.10 KOO29696.1 - 0.047 13.4 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal WGR PF05406.15 KOO29696.1 - 0.15 12.1 3.1 1 9.5 3.1 2.2 1 1 0 1 1 1 0 WGR domain PNTB PF02233.16 KOO29697.1 - 2.9e-165 550.7 25.6 2.5e-164 547.5 16.3 2.2 2 0 0 2 2 2 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 KOO29697.1 - 1.9e-66 223.4 2.7 3.5e-66 222.6 1.5 2.2 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 KOO29697.1 - 9.7e-33 113.4 0.2 2.5e-32 112.0 0.0 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 KOO29697.1 - 8.8e-28 96.6 3.0 8.8e-28 96.6 3.0 3.8 2 1 0 2 2 2 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 KOO29697.1 - 0.00046 19.6 0.2 0.065 12.6 0.1 2.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_M PF00205.22 KOO29697.1 - 0.00068 19.4 0.1 0.0029 17.3 0.1 2.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Pyr_redox_2 PF07992.14 KOO29697.1 - 0.0052 16.1 0.2 0.013 14.7 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 KOO29697.1 - 0.0074 16.3 1.5 0.022 14.7 0.2 2.6 3 0 0 3 3 3 1 Zinc-binding dehydrogenase NAD_binding_8 PF13450.6 KOO29697.1 - 0.018 15.2 0.5 0.083 13.1 0.5 2.2 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 KOO29697.1 - 0.054 13.4 0.3 0.11 12.4 0.3 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TPR_2 PF07719.17 KOO29698.1 - 1.6e-07 30.9 0.1 0.19 11.9 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO29698.1 - 8.6e-05 22.2 0.0 1.5 8.8 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO29698.1 - 0.0059 17.3 0.2 6.5 7.9 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO29698.1 - 0.02 15.6 0.1 26 5.6 0.0 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO29698.1 - 0.059 13.1 0.1 3 7.6 0.0 2.7 3 0 0 3 3 3 0 TPR repeat NPR2 PF06218.11 KOO29699.1 - 1.2e-30 106.7 0.0 1.4e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Nitrogen permease regulator 2 GhoS PF11080.8 KOO29700.1 - 0.0098 15.9 0.2 0.025 14.6 0.0 1.8 2 0 0 2 2 2 1 Endoribonuclease GhoS ATP-synt_E PF05680.12 KOO29700.1 - 0.074 13.4 7.2 3.1 8.2 0.1 2.4 2 0 0 2 2 2 0 ATP synthase E chain DUF4407 PF14362.6 KOO29700.1 - 0.76 9.1 11.5 1.1 8.6 11.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cytochrom_C552 PF02335.15 KOO29700.1 - 1.2 7.9 5.5 1.5 7.6 5.5 1.2 1 0 0 1 1 1 0 Cytochrome c552 Peptidase_S49_N PF08496.10 KOO29700.1 - 1.5 8.9 8.0 0.5 10.4 3.4 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal WD40 PF00400.32 KOO29701.1 - 1e-64 212.9 17.9 1.2e-09 38.6 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO29701.1 - 4.1e-15 55.9 0.0 0.0039 17.5 0.0 5.5 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO29701.1 - 3.2e-10 39.5 3.6 0.051 12.5 0.1 5.5 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KOO29701.1 - 1.2e-06 27.5 9.3 0.011 14.4 0.1 4.5 1 1 3 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 KOO29701.1 - 0.0015 18.4 0.0 0.35 10.7 0.0 3.1 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 KOO29701.1 - 0.0039 17.1 1.3 21 5.2 0.1 3.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 KOO29701.1 - 0.0092 15.3 1.5 1.6 8.0 0.2 3.5 1 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 KOO29701.1 - 0.056 11.8 0.2 11 4.1 0.0 2.7 1 1 1 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 KOO29701.1 - 0.095 11.2 0.0 1.2 7.6 0.0 2.2 1 1 2 3 3 3 0 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 KOO29701.1 - 0.43 10.3 5.4 1.6 8.5 0.1 3.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Filamin PF00630.19 KOO29702.1 - 3.2e-68 227.0 0.0 9.4e-17 61.7 0.0 9.1 9 1 0 9 9 9 7 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO29702.1 - 4e-09 36.6 0.0 0.34 11.2 0.0 5.8 6 0 0 6 6 6 3 Invasin, domain 3 DUF5060 PF16586.5 KOO29702.1 - 2.5e-05 24.6 0.5 5.4 7.5 0.0 4.3 4 0 0 4 4 4 2 Domain of unknown function (DUF5060) YtkA PF13115.6 KOO29702.1 - 0.00011 22.7 0.3 3.2 8.4 0.0 4.7 4 0 0 4 4 4 1 YtkA-like Y_Y_Y PF07495.13 KOO29702.1 - 0.08 12.9 0.0 20 5.2 0.0 3.4 3 0 0 3 3 3 0 Y_Y_Y domain EGF_Tenascin PF18720.1 KOO29704.1 - 4.5e-34 115.9 198.4 3.6e-05 23.7 12.4 13.4 13 0 0 13 13 13 11 Tenascin EGF domain EGF_2 PF07974.13 KOO29704.1 - 2.9e-33 113.9 232.0 3.7e-05 24.0 10.7 12.9 13 0 0 13 13 13 12 EGF-like domain Kelch_4 PF13418.6 KOO29704.1 - 1.6e-24 85.6 3.1 1.5e-09 37.7 0.0 5.5 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KOO29704.1 - 1.4e-20 72.6 9.1 8.9e-05 22.0 0.0 6.6 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.6 KOO29704.1 - 1.2e-19 70.0 16.8 8.7e-07 29.1 0.1 6.9 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO29704.1 - 3.5e-16 58.9 4.0 0.031 14.6 0.0 5.8 3 2 2 5 5 5 5 Kelch motif Kelch_5 PF13854.6 KOO29704.1 - 2.4e-14 52.9 3.3 0.0015 18.5 0.1 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 KOO29704.1 - 2.3e-13 49.6 0.1 0.52 10.4 0.0 6.1 5 0 0 5 5 5 5 Kelch motif EGF PF00008.27 KOO29704.1 - 0.0097 16.2 175.5 0.088 13.1 6.1 13.1 12 0 0 12 12 12 7 EGF-like domain EGF_2 PF07974.13 KOO29705.1 - 1.1e-47 160.0 293.0 3.1e-05 24.2 12.8 15.8 15 0 0 15 15 15 15 EGF-like domain EGF_Tenascin PF18720.1 KOO29705.1 - 1.1e-35 121.1 235.2 0.00017 21.6 5.1 15.6 15 0 0 15 15 15 14 Tenascin EGF domain Kelch_4 PF13418.6 KOO29705.1 - 3.3e-23 81.4 7.6 2e-09 37.3 0.0 6.5 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KOO29705.1 - 1.5e-17 62.9 20.8 0.00012 21.5 0.0 7.9 9 0 0 9 9 9 5 Kelch motif Kelch_3 PF13415.6 KOO29705.1 - 2.7e-16 59.4 26.9 1.2e-06 28.6 0.1 8.1 9 0 0 9 9 9 5 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO29705.1 - 3e-15 55.9 5.2 0.042 14.2 0.0 6.0 3 2 3 6 6 6 4 Kelch motif Kelch_5 PF13854.6 KOO29705.1 - 3e-13 49.4 4.9 0.0021 18.0 0.1 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 KOO29705.1 - 9.8e-13 47.5 0.6 0.72 9.9 0.0 6.5 6 0 0 6 6 6 5 Kelch motif HSP70 PF00012.20 KOO29706.1 - 3.8e-94 316.0 12.2 3.2e-91 306.4 12.2 2.9 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOO29706.1 - 1.4e-06 27.4 0.0 0.0073 15.2 0.0 2.7 1 1 0 2 2 2 2 MreB/Mbl protein TAN PF11640.8 KOO29706.1 - 0.06 13.5 2.0 0.25 11.5 0.6 2.4 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair WW PF00397.26 KOO29708.1 - 5.5e-26 90.3 5.6 1.3e-12 47.5 1.6 2.6 2 0 0 2 2 2 2 WW domain BAR PF03114.18 KOO29708.1 - 1.8e-11 44.1 0.7 3.5e-11 43.2 0.7 1.4 1 1 0 1 1 1 1 BAR domain SH3_2 PF07653.17 KOO29708.1 - 2.5e-09 36.7 0.0 5e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOO29708.1 - 2.1e-08 33.9 0.1 1.9e-07 30.8 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KOO29708.1 - 3.1e-05 23.5 0.5 0.00018 21.1 0.0 2.5 3 0 0 3 3 3 1 SH3 domain Glyco_hyd_101C PF17451.2 KOO29708.1 - 0.033 14.5 0.5 3.5 7.9 0.1 2.5 2 0 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain Arfaptin PF06456.13 KOO29708.1 - 0.065 12.8 0.1 0.14 11.7 0.0 1.5 2 0 0 2 2 2 0 Arfaptin-like domain T2SSF PF00482.23 KOO29708.1 - 0.11 12.4 0.9 3.2 7.7 0.0 2.3 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Aldedh PF00171.22 KOO29709.1 - 2.3e-159 530.8 0.2 2.6e-159 530.6 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family AAA PF00004.29 KOO29710.1 - 4.1e-15 56.4 0.0 7.8e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 KOO29710.1 - 4.4e-15 55.8 0.1 1.1e-14 54.6 0.0 1.7 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 KOO29710.1 - 1.3e-11 44.5 0.0 2.4e-10 40.4 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_30 PF13604.6 KOO29710.1 - 1.4e-05 24.9 0.0 4.8e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO29710.1 - 4.5e-05 23.7 0.0 0.00068 19.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 KOO29710.1 - 7.2e-05 22.8 0.0 0.00014 21.8 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 KOO29710.1 - 0.00018 21.9 0.0 0.0068 16.8 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 KOO29710.1 - 0.0002 21.2 0.0 0.00039 20.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KOO29710.1 - 0.00024 20.9 0.0 0.0025 17.6 0.0 2.3 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain ResIII PF04851.15 KOO29710.1 - 0.00034 20.6 0.0 0.00063 19.8 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 KOO29710.1 - 0.0007 19.5 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO29710.1 - 0.0026 18.1 0.0 0.015 15.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO29710.1 - 0.0029 17.6 0.0 0.014 15.4 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KOO29710.1 - 0.01 15.4 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_assoc_2 PF16193.5 KOO29710.1 - 0.011 16.1 0.0 0.035 14.4 0.0 2.0 1 0 0 1 1 1 0 AAA C-terminal domain DUF2075 PF09848.9 KOO29710.1 - 0.014 14.6 0.0 0.033 13.4 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DNA_pol3_gamma3 PF12169.8 KOO29710.1 - 0.015 15.2 1.8 2.9 7.8 0.1 2.6 1 1 1 2 2 2 0 DNA polymerase III subunits gamma and tau domain III AAA_14 PF13173.6 KOO29710.1 - 0.017 15.2 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain TK PF00265.18 KOO29710.1 - 0.021 14.7 0.0 0.26 11.1 0.0 2.1 2 0 0 2 2 2 0 Thymidine kinase Mg_chelatase PF01078.21 KOO29710.1 - 0.033 13.6 0.0 0.69 9.3 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 KOO29710.1 - 0.062 13.2 0.0 0.093 12.6 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PhoH PF02562.16 KOO29710.1 - 0.091 12.2 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein DUF815 PF05673.13 KOO29710.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Peptidase_S8 PF00082.22 KOO29711.1 - 2.7e-10 40.0 4.8 3.2e-05 23.4 1.8 2.5 1 1 1 2 2 2 2 Subtilase family S-layer PF07752.11 KOO29711.1 - 0.14 11.1 0.2 0.26 10.3 0.2 1.3 1 0 0 1 1 1 0 S-layer protein Pyrophosphatase PF00719.19 KOO29712.1 - 1.5e-45 154.9 0.1 2.9e-45 154.0 0.1 1.5 1 0 0 1 1 1 1 Inorganic pyrophosphatase DIOX_N PF14226.6 KOO29713.1 - 5.3e-16 59.4 0.0 6.1e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal EF-hand_7 PF13499.6 KOO29714.1 - 7.2e-05 23.2 5.0 9.5e-05 22.8 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO29714.1 - 0.019 15.3 0.1 0.019 15.3 0.1 3.0 3 0 0 3 3 3 0 EF-hand domain CDC45 PF02724.14 KOO29714.1 - 0.022 13.1 0.3 0.024 12.9 0.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Drc1-Sld2 PF11719.8 KOO29714.1 - 1.6 8.2 4.7 2.1 7.8 4.7 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein Pes-10 PF07149.11 KOO29714.1 - 2.3 7.2 11.3 3.2 6.7 11.3 1.1 1 0 0 1 1 1 0 Pes-10 Astro_capsid_p PF12226.8 KOO29714.1 - 2.5 7.2 14.1 4 6.5 14.1 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.12 KOO29714.1 - 5.3 5.1 8.5 7.2 4.7 8.5 1.2 1 0 0 1 1 1 0 Nop14-like family bMG6 PF17962.1 KOO29715.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial macroglobulin domain 6 WD40 PF00400.32 KOO29719.1 - 2.7e-62 205.2 37.0 3.9e-09 37.0 0.4 8.4 7 2 1 8 8 8 7 WD domain, G-beta repeat PD40 PF07676.12 KOO29719.1 - 4.1e-20 71.2 6.1 0.11 12.5 0.0 8.6 8 0 0 8 8 8 7 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 KOO29719.1 - 9.8e-18 64.3 4.5 0.0095 16.2 0.1 6.6 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO29719.1 - 1.9e-17 63.2 12.2 0.0085 15.1 0.1 7.1 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOO29719.1 - 2e-11 44.1 0.1 0.001 19.0 0.0 3.7 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 KOO29719.1 - 1.5e-09 36.7 0.0 0.059 11.7 0.0 4.3 1 1 4 5 5 5 5 WD repeat-containing and planar cell polarity effector protein Fritz BBS2_Mid PF14783.6 KOO29719.1 - 5.1e-06 26.5 0.2 0.46 10.5 0.0 4.9 2 2 3 5 5 5 1 Ciliary BBSome complex subunit 2, middle region dsrm PF00035.26 KOO29719.1 - 0.0053 17.4 0.5 30 5.4 0.0 4.2 4 0 0 4 4 4 0 Double-stranded RNA binding motif WD40_like PF17005.5 KOO29719.1 - 0.038 13.3 0.8 73 2.5 0.0 4.1 3 1 1 5 5 5 0 WD40-like domain WD40_3 PF15911.5 KOO29719.1 - 0.47 10.5 4.8 2.3e+02 1.9 0.0 5.5 7 1 0 7 7 7 0 WD domain, G-beta repeat B_lectin PF01453.24 KOO29719.1 - 2.5 8.7 7.1 34 5.0 0.6 3.6 1 1 1 3 3 3 0 D-mannose binding lectin eIF-5a PF01287.20 KOO29720.1 - 4e-19 68.5 0.0 6.2e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 KOO29720.1 - 9.1e-05 22.4 0.8 0.00015 21.7 0.1 1.8 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain EF-hand_5 PF13202.6 KOO29720.1 - 0.021 14.3 0.2 0.051 13.1 0.2 1.6 1 0 0 1 1 1 0 EF hand LRR_6 PF13516.6 KOO29721.1 - 4.5e-08 32.5 27.4 0.11 12.6 0.1 9.1 9 0 0 9 9 9 4 Leucine Rich repeat SAM_1 PF00536.30 KOO29721.1 - 2.8e-07 30.9 0.0 4.8e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO29721.1 - 1.5e-06 28.2 0.0 3.8e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 KOO29721.1 - 0.0039 17.0 0.0 0.0065 16.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KOO29721.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 SH3 domain EF-hand_1 PF00036.32 KOO29722.1 - 2.7e-05 23.4 0.0 3.8e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO29722.1 - 5e-05 22.9 0.0 7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 KOO29722.1 - 0.00016 21.5 0.0 0.0002 21.1 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO29722.1 - 0.0008 18.8 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO29722.1 - 0.00093 19.6 0.0 0.00098 19.5 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO29725.1 - 6.2e-30 100.5 5.8 0.00024 20.8 0.0 9.5 10 0 0 10 10 10 6 EF-hand domain EF-hand_1 PF00036.32 KOO29725.1 - 2.2e-29 98.8 8.7 6.2e-05 22.3 0.5 9.1 10 0 0 10 10 10 6 EF hand EF-hand_7 PF13499.6 KOO29725.1 - 4.8e-25 87.8 8.4 2.4e-07 31.1 0.0 7.2 4 2 4 8 8 8 7 EF-hand domain pair EF-hand_5 PF13202.6 KOO29725.1 - 7.3e-23 79.0 11.4 8.6e-06 25.0 0.0 7.3 7 0 0 7 7 7 5 EF hand EF-hand_8 PF13833.6 KOO29725.1 - 1.4e-17 63.2 9.7 0.00017 21.4 1.3 6.8 4 3 2 6 6 6 5 EF-hand domain pair EF-hand_4 PF12763.7 KOO29725.1 - 0.00023 21.1 2.9 0.08 12.9 0.1 3.7 3 1 1 4 4 4 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO29725.1 - 0.00048 20.4 0.3 8.6 6.7 0.0 3.8 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO29725.1 - 0.00062 20.0 0.0 30 5.0 0.0 5.5 7 0 0 7 7 7 0 EF-hand domain Dockerin_1 PF00404.18 KOO29725.1 - 0.003 17.7 0.0 16 5.8 0.0 3.5 3 0 0 3 3 3 1 Dockerin type I domain RST PF12174.8 KOO29725.1 - 0.0053 16.6 0.0 3.8 7.5 0.0 3.5 3 0 0 3 3 3 1 RCD1-SRO-TAF4 (RST) plant domain Transcript_VP30 PF11507.8 KOO29725.1 - 0.13 12.3 0.1 0.45 10.6 0.0 1.9 2 0 0 2 2 2 0 Ebola virus-specific transcription factor VP30 AAA PF00004.29 KOO29726.1 - 4.4e-41 140.4 0.2 5.6e-17 62.4 0.0 4.9 5 0 0 5 5 5 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOO29726.1 - 1.1e-12 48.3 3.0 0.33 11.2 0.0 6.5 3 3 1 4 4 4 3 AAA domain RuvB_N PF05496.12 KOO29726.1 - 1.7e-12 47.4 0.1 0.0014 18.4 0.0 3.7 3 0 0 3 3 3 3 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_6 PF17866.1 KOO29726.1 - 6.2e-12 45.5 9.8 6.1e-05 23.1 0.2 3.9 3 0 0 3 3 3 2 AAA lid domain AAA_30 PF13604.6 KOO29726.1 - 5.3e-11 42.6 0.5 0.0034 17.1 0.0 3.9 3 0 0 3 3 3 3 AAA domain Mg_chelatase PF01078.21 KOO29726.1 - 2.8e-10 39.9 2.5 0.042 13.2 0.0 5.0 3 2 2 5 5 5 3 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 KOO29726.1 - 1.4e-08 35.2 4.1 0.0039 17.5 0.3 4.8 4 1 0 4 4 3 2 AAA domain AAA_16 PF13191.6 KOO29726.1 - 5.2e-08 33.5 5.7 0.03 14.7 0.0 4.4 4 1 0 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 KOO29726.1 - 1.4e-07 31.6 2.6 0.2 11.7 0.0 4.2 4 1 0 4 4 3 3 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KOO29726.1 - 2.3e-07 30.7 0.2 0.02 14.7 0.0 3.5 3 0 0 3 3 3 2 IstB-like ATP binding protein Sigma54_activat PF00158.26 KOO29726.1 - 1.1e-06 28.5 3.2 0.048 13.4 0.2 5.4 3 2 0 3 3 3 1 Sigma-54 interaction domain Viral_helicase1 PF01443.18 KOO29726.1 - 1.2e-06 28.5 0.2 0.67 9.7 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 KOO29726.1 - 1.3e-06 29.0 2.3 0.23 12.0 0.0 3.8 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 KOO29726.1 - 1.7e-05 25.2 0.2 2.3 8.7 0.0 3.6 3 0 0 3 3 3 1 RNA helicase AAA_33 PF13671.6 KOO29726.1 - 2.2e-05 24.6 5.8 0.076 13.2 0.0 4.7 4 0 0 4 4 4 1 AAA domain AAA_2 PF07724.14 KOO29726.1 - 3.1e-05 24.1 0.1 0.57 10.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) ABC_tran PF00005.27 KOO29726.1 - 5.8e-05 23.6 1.6 6.9 7.2 0.2 3.8 3 0 0 3 3 3 0 ABC transporter KTI12 PF08433.10 KOO29726.1 - 6.5e-05 22.5 0.1 0.52 9.7 0.0 3.3 3 0 0 3 3 3 1 Chromatin associated protein KTI12 AAA_24 PF13479.6 KOO29726.1 - 8.4e-05 22.4 4.2 2.8 7.6 0.2 4.0 3 1 1 4 4 4 1 AAA domain AAA_28 PF13521.6 KOO29726.1 - 0.00012 22.4 8.9 0.049 13.9 0.1 4.6 5 0 0 5 5 3 1 AAA domain Sigma54_activ_2 PF14532.6 KOO29726.1 - 0.00039 20.6 0.5 0.76 9.9 0.0 4.3 4 1 0 4 4 4 1 Sigma-54 interaction domain AAA_7 PF12775.7 KOO29726.1 - 0.00044 19.8 0.5 5 6.6 0.0 3.3 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_3 PF07726.11 KOO29726.1 - 0.00052 19.9 0.0 3.3 7.6 0.0 3.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 KOO29726.1 - 0.001 19.5 2.8 1.3 9.5 0.1 4.2 3 0 0 3 3 3 1 AAA domain Torsin PF06309.11 KOO29726.1 - 0.0054 16.8 0.0 29 4.8 0.0 3.7 3 0 0 3 3 3 0 Torsin Zeta_toxin PF06414.12 KOO29726.1 - 0.0066 15.8 0.1 4.9 6.4 0.0 3.5 3 0 0 3 3 3 0 Zeta toxin PRK PF00485.18 KOO29726.1 - 0.0091 15.7 0.2 1.9 8.2 0.0 3.0 3 0 0 3 3 3 1 Phosphoribulokinase / Uridine kinase family CbiA PF01656.23 KOO29726.1 - 0.01 15.9 2.2 0.47 10.5 0.0 3.8 4 0 0 4 4 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATPase PF06745.13 KOO29726.1 - 0.011 15.1 1.3 5.4 6.3 0.1 3.5 3 0 0 3 3 3 0 KaiC AAA_11 PF13086.6 KOO29726.1 - 0.015 15.1 5.1 1.6 8.4 0.0 4.3 5 0 0 5 5 4 0 AAA domain ResIII PF04851.15 KOO29726.1 - 0.017 15.2 0.4 18 5.3 0.0 4.0 4 1 1 5 5 4 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 KOO29726.1 - 0.017 15.1 2.4 8 6.3 0.1 3.6 3 0 0 3 3 3 0 NTPase DUF815 PF05673.13 KOO29726.1 - 0.02 14.1 0.1 9.4 5.3 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF815) TsaE PF02367.17 KOO29726.1 - 0.022 14.7 0.4 6.9 6.7 0.0 3.3 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE APS_kinase PF01583.20 KOO29726.1 - 0.029 14.3 0.3 14 5.5 0.0 3.9 4 0 0 4 4 4 0 Adenylylsulphate kinase SRP1_TIP1 PF00660.17 KOO29726.1 - 0.045 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Seripauperin and TIP1 family AAA_29 PF13555.6 KOO29726.1 - 0.06 13.1 0.0 8.7 6.2 0.0 3.3 3 0 0 3 3 3 0 P-loop containing region of AAA domain NACHT PF05729.12 KOO29726.1 - 0.07 13.1 2.7 15 5.5 0.1 3.7 3 0 0 3 3 3 0 NACHT domain DUF2075 PF09848.9 KOO29726.1 - 0.099 11.9 4.6 11 5.1 0.1 4.0 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.9 KOO29726.1 - 0.11 11.3 1.2 2.1 7.2 0.0 2.9 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain SRP54 PF00448.22 KOO29726.1 - 0.15 11.7 2.9 5.5 6.6 0.1 3.4 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain PhoH PF02562.16 KOO29726.1 - 0.15 11.5 3.4 27 4.1 0.0 4.1 4 1 0 4 4 4 0 PhoH-like protein SKI PF01202.22 KOO29726.1 - 0.17 12.0 3.1 3.9 7.6 0.0 3.6 3 0 0 3 3 3 0 Shikimate kinase TIP49 PF06068.13 KOO29726.1 - 0.26 10.5 1.5 9.3 5.3 0.0 3.8 4 1 1 5 5 4 0 TIP49 P-loop domain Mur_ligase_M PF08245.12 KOO29726.1 - 0.33 10.9 1.3 12 5.8 0.1 3.2 3 0 0 3 3 3 0 Mur ligase middle domain ATP_bind_1 PF03029.17 KOO29726.1 - 2.6 7.8 4.5 3.7 7.2 0.1 3.0 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein DUF4551 PF15087.6 KOO29728.1 - 0.61 8.8 5.4 1.1 8.0 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Nop53 PF07767.11 KOO29728.1 - 3.2 7.1 16.6 6.8 6.0 16.6 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Chromo PF00385.24 KOO29730.1 - 5.1e-07 29.5 0.0 9e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Stc1 PF12898.7 KOO29730.1 - 0.00023 21.7 1.6 0.00044 20.7 1.6 1.5 1 0 0 1 1 1 1 Stc1 domain TackOD1 PF18551.1 KOO29730.1 - 0.014 15.1 0.6 0.026 14.2 0.6 1.4 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Pkinase PF00069.25 KOO29731.1 - 1.2e-37 129.8 0.0 2e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29731.1 - 1.3e-16 60.7 0.1 2.2e-16 60.0 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO29731.1 - 0.016 14.6 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 KOO29731.1 - 0.083 12.8 0.1 0.24 11.3 0.0 1.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO29731.1 - 0.18 10.7 0.1 0.18 10.7 0.1 1.9 2 0 0 2 2 2 0 Haspin like kinase domain Amidohydro_1 PF01979.20 KOO29733.1 - 3.9e-06 26.4 0.0 8.3e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KOO29733.1 - 0.00012 21.8 2.1 0.0012 18.4 0.1 2.5 3 0 0 3 3 3 2 Amidohydrolase family Brix PF04427.18 KOO29736.1 - 1e-28 100.8 0.0 1.4e-28 100.3 0.0 1.2 1 0 0 1 1 1 1 Brix domain Mqo PF06039.15 KOO29739.1 - 6.4e-181 602.2 0.0 5.2e-180 599.2 0.0 1.9 1 1 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) DAO PF01266.24 KOO29739.1 - 4.2e-08 33.2 0.0 5.9e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 KOO29740.1 - 1.9e-44 152.7 0.9 2.9e-44 152.1 0.9 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T PF01571.21 KOO29740.1 - 1.1e-33 116.7 0.0 1.8e-33 116.0 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain FAO_M PF16350.5 KOO29740.1 - 8e-10 38.9 0.2 1.8e-09 37.8 0.2 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Pyr_redox_2 PF07992.14 KOO29740.1 - 1.8e-08 34.0 0.5 9.3e-05 21.8 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GCV_T_C PF08669.11 KOO29740.1 - 2.2e-08 33.9 0.0 1.1e-07 31.7 0.0 2.2 2 0 0 2 2 2 1 Glycine cleavage T-protein C-terminal barrel domain Amino_oxidase PF01593.24 KOO29740.1 - 0.00011 21.6 0.0 0.0002 20.8 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 KOO29740.1 - 0.00069 18.8 4.5 0.14 11.1 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein HI0933_like PF03486.14 KOO29740.1 - 0.0011 17.7 4.0 0.28 9.8 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 KOO29740.1 - 0.0013 18.9 3.3 0.0034 17.6 3.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 KOO29740.1 - 0.0094 15.1 1.4 0.039 13.1 0.6 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 KOO29740.1 - 0.0098 15.2 2.4 0.068 12.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO29740.1 - 0.016 14.4 3.6 0.078 12.2 2.0 2.1 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 KOO29740.1 - 0.02 15.4 1.7 0.18 12.4 1.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 KOO29740.1 - 0.03 14.2 0.3 0.054 13.4 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 KOO29740.1 - 0.031 14.3 5.0 0.95 9.4 0.2 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 KOO29740.1 - 0.87 8.4 2.3 24 3.6 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_2 PF00890.24 KOO29740.1 - 9 5.3 9.2 26 3.7 9.2 1.9 1 1 0 1 1 1 0 FAD binding domain tRNA_U5-meth_tr PF05958.11 KOO29742.1 - 2.6e-13 49.7 0.0 5.3e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 KOO29742.1 - 1.9e-09 37.5 0.1 3.3e-09 36.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO29742.1 - 1e-06 29.3 1.3 1.5e-06 28.8 0.1 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOO29742.1 - 2.6e-06 27.5 0.0 5.7e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOO29742.1 - 9.6e-06 25.2 0.6 1.8e-05 24.3 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 KOO29742.1 - 0.00025 20.7 0.0 0.00044 19.9 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_4 PF02390.17 KOO29742.1 - 0.00028 20.4 0.1 0.00045 19.7 0.1 1.3 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 KOO29742.1 - 0.0005 19.6 0.2 0.0011 18.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 KOO29742.1 - 0.011 15.6 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RRM_1 PF00076.22 KOO29742.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ubie_methyltran PF01209.18 KOO29742.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 KOO29742.1 - 0.013 16.2 0.0 0.039 14.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 KOO29742.1 - 0.034 13.7 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase NodS PF05401.11 KOO29742.1 - 0.077 12.6 0.4 0.17 11.4 0.4 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) PCMT PF01135.19 KOO29742.1 - 0.14 11.9 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 KOO29742.1 - 0.2 11.3 1.2 1.2 8.8 1.2 2.0 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Ring_hydroxyl_A PF00848.19 KOO29743.1 - 3.9e-36 125.0 0.0 6.1e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 KOO29743.1 - 1.8e-16 59.9 0.0 3.2e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Galactosyl_T PF01762.21 KOO29746.1 - 2e-17 63.6 0.0 3.4e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 KOO29746.1 - 0.035 13.5 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 Fringe-like SSF PF00474.17 KOO29747.1 - 1.5e-13 50.4 32.0 7.5e-13 48.1 32.0 2.0 1 1 0 1 1 1 1 Sodium:solute symporter family RSN1_7TM PF02714.15 KOO29748.1 - 0.002 17.5 2.4 0.002 17.5 2.4 2.7 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 KOO29748.1 - 1.7 8.4 6.5 2.2 8.0 0.0 3.6 4 0 0 4 4 4 0 Late exocytosis, associated with Golgi transport DUF4713 PF15831.5 KOO29748.1 - 7.8 7.0 17.7 26 5.4 17.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) HD_6 PF18019.1 KOO29749.1 - 0.048 13.8 0.0 0.072 13.2 0.0 1.3 1 0 0 1 1 1 0 HD domain Usp PF00582.26 KOO29750.1 - 4.1e-08 33.8 2.0 0.02 15.4 0.0 3.2 2 1 0 2 2 2 2 Universal stress protein family PX PF00787.24 KOO29752.1 - 1.2e-05 25.2 0.0 2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 PX domain GARP PF16731.5 KOO29754.1 - 0.0038 16.9 14.1 0.0069 16.1 14.1 1.3 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma GATA PF00320.27 KOO29755.1 - 1.3e-14 53.5 29.2 1.2e-05 24.8 4.3 6.0 6 0 0 6 6 6 4 GATA zinc finger zf-C2H2_6 PF13912.6 KOO29755.1 - 4.8e-11 42.4 27.7 0.0014 18.6 0.2 7.2 8 0 0 8 8 7 4 C2H2-type zinc finger WSD PF15613.6 KOO29755.1 - 4.5e-10 39.9 0.1 2.6e-09 37.4 0.0 2.4 3 0 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif zf-C2H2_jaz PF12171.8 KOO29755.1 - 7e-05 23.0 0.0 28 5.1 0.0 5.8 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Trm112p PF03966.16 KOO29755.1 - 0.0091 16.6 5.9 0.21 12.2 1.3 4.4 3 0 0 3 3 3 1 Trm112p-like protein zf-MYST PF17772.1 KOO29755.1 - 0.068 12.8 2.2 1.1 8.9 0.0 3.7 4 0 0 4 4 4 0 MYST family zinc finger domain zf_UBZ PF18439.1 KOO29755.1 - 0.19 11.4 13.3 17 5.1 0.0 5.9 7 0 0 7 7 7 0 Ubiquitin-Binding Zinc Finger Rad50_zn_hook PF04423.14 KOO29755.1 - 0.49 10.3 2.4 10 6.0 0.2 3.4 3 0 0 3 3 3 0 Rad50 zinc hook motif DUF3039 PF11238.8 KOO29755.1 - 0.86 9.4 7.2 3.1 7.6 0.2 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3039) zf-C2H2_9 PF16293.5 KOO29755.1 - 2.3 8.1 11.7 1.1e+02 2.7 0.1 6.4 7 0 0 7 7 6 0 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 KOO29755.1 - 2.9 8.5 32.0 0.82 10.2 0.6 7.5 7 0 0 7 7 6 0 Zinc finger, C2H2 type zf-FPG_IleRS PF06827.14 KOO29755.1 - 3.6 7.5 20.6 11 6.0 0.9 5.5 5 0 0 5 5 5 0 Zinc finger found in FPG and IleRS DUF4440 PF14534.6 KOO29756.1 - 3.7e-07 30.5 0.5 0.086 13.3 0.0 4.2 3 1 0 3 3 3 2 Domain of unknown function (DUF4440) CSD PF00313.22 KOO29756.1 - 3.5e-05 23.6 1.5 4.8 7.1 0.0 3.7 3 0 0 3 3 3 3 'Cold-shock' DNA-binding domain OB_NTP_bind PF07717.16 KOO29756.1 - 0.0024 18.2 0.1 4.6 7.7 0.1 3.3 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold SnoaL_2 PF12680.7 KOO29756.1 - 0.0063 17.1 1.2 0.66 10.6 0.0 3.4 3 1 1 4 4 4 1 SnoaL-like domain ComC PF03047.14 KOO29756.1 - 0.17 11.7 2.9 44 4.0 0.2 3.4 3 0 0 3 3 3 0 COMC family DUF220 PF02713.14 KOO29756.1 - 5.9 7.1 7.2 52 4.0 0.2 3.9 4 0 0 4 4 4 0 Domain of unknown function DUF220 RPAP3_C PF13877.6 KOO29757.1 - 4.2e-14 52.8 0.0 1e-13 51.6 0.0 1.7 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_2 PF07719.17 KOO29757.1 - 8.8e-05 22.3 11.5 0.013 15.5 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO29757.1 - 0.00038 20.2 8.1 0.03 14.2 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO29757.1 - 0.0013 19.3 2.8 0.0013 19.3 2.8 6.0 5 2 2 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO29757.1 - 0.023 14.4 1.0 1.8 8.3 0.4 2.8 2 0 0 2 2 2 0 TPR repeat TPR_17 PF13431.6 KOO29757.1 - 0.078 13.4 0.0 0.29 11.6 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO29757.1 - 0.14 12.9 5.0 0.59 10.9 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO29757.1 - 0.19 12.0 2.1 0.26 11.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO29757.1 - 0.27 11.4 12.8 0.26 11.5 7.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat ABC_tran PF00005.27 KOO29758.1 - 8.5e-30 104.1 0.0 1.3e-29 103.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOO29758.1 - 3e-13 50.0 0.0 3.9e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 KOO29758.1 - 2.2e-07 30.5 0.1 2.5e-05 23.8 0.0 2.0 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 KOO29758.1 - 9.9e-06 25.3 0.2 0.00041 20.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO29758.1 - 0.00018 21.9 0.8 0.00051 20.5 0.8 1.7 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 KOO29758.1 - 0.00021 21.3 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_29 PF13555.6 KOO29758.1 - 0.0012 18.5 0.1 0.0024 17.6 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 KOO29758.1 - 0.0025 17.7 1.7 1.3 8.7 0.5 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 KOO29758.1 - 0.01 16.0 0.1 0.022 14.9 0.1 1.5 2 0 0 2 2 1 0 Helicase HerA, central domain Mg_chelatase PF01078.21 KOO29758.1 - 0.021 14.2 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 KOO29758.1 - 0.023 14.9 0.1 0.15 12.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 KOO29758.1 - 0.036 13.7 0.1 0.062 12.9 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain IstB_IS21 PF01695.17 KOO29758.1 - 0.045 13.5 0.0 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_5 PF07728.14 KOO29758.1 - 0.067 13.2 0.1 0.21 11.6 0.1 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 KOO29758.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 KOO29758.1 - 0.14 12.1 0.3 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 KOO29758.1 - 0.18 12.3 0.0 0.37 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Herpes_BLLF1 PF05109.13 KOO29758.1 - 6.7 4.6 17.4 9.1 4.1 17.4 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Vac14_Fig4_bd PF11916.8 KOO29760.1 - 1.1e-69 233.6 0.8 1.1e-69 233.6 0.8 2.4 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 KOO29760.1 - 1.2e-43 147.6 0.1 2e-36 124.5 0.1 4.1 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KOO29760.1 - 7.9e-10 38.1 0.2 0.084 13.2 0.0 6.8 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 KOO29760.1 - 3.7e-07 30.4 1.3 0.51 10.8 0.1 5.1 2 2 0 3 3 3 2 HEAT repeats Cnd1 PF12717.7 KOO29760.1 - 3.7e-06 27.1 0.8 0.024 14.7 0.1 3.8 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 KOO29760.1 - 0.00035 20.7 1.1 0.075 13.2 0.0 3.7 2 1 2 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 NopRA1 PF16201.5 KOO29760.1 - 0.0005 19.7 3.1 2.2 7.8 0.8 3.7 3 0 0 3 3 3 2 Nucleolar pre-ribosomal-associated protein 1 Tti2 PF10521.9 KOO29760.1 - 0.0011 18.5 0.2 0.87 9.1 0.0 3.8 3 1 0 3 3 3 1 Tti2 family HEAT_EZ PF13513.6 KOO29760.1 - 0.0018 18.8 6.8 4.6 7.8 0.0 5.8 6 1 1 7 7 7 2 HEAT-like repeat Xpo1 PF08389.12 KOO29760.1 - 0.0033 17.5 4.7 1.1 9.3 0.0 4.4 4 1 1 5 5 5 1 Exportin 1-like protein UME PF08064.13 KOO29760.1 - 0.021 14.7 3.3 3.6 7.6 0.0 3.7 1 1 1 2 2 2 0 UME (NUC010) domain RIX1 PF08167.12 KOO29760.1 - 0.055 13.2 3.7 0.42 10.3 0.2 3.2 2 1 1 3 3 3 0 rRNA processing/ribosome biogenesis Ipi1_N PF12333.8 KOO29760.1 - 0.21 12.2 2.1 0.6 10.7 1.2 2.3 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation V-ATPase_H_N PF03224.14 KOO29760.1 - 0.58 9.4 6.5 0.19 11.0 1.9 2.4 2 1 0 3 3 3 0 V-ATPase subunit H ThiF PF00899.21 KOO29761.1 - 1.4e-64 217.8 0.0 1.9e-64 217.3 0.0 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 KOO29761.1 - 2.4e-13 50.0 0.0 3.7e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 E2 binding domain AlaDh_PNT_C PF01262.21 KOO29761.1 - 0.0073 15.6 0.1 0.53 9.5 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain ANAPC4_WD40 PF12894.7 KOO29762.1 - 1.9e-06 28.1 0.0 0.2 12.0 0.0 3.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOO29762.1 - 7.7e-06 26.6 0.3 1.2 10.1 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO29762.1 - 0.0041 16.1 0.4 3.4 6.5 0.0 3.3 4 0 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein TruB_C PF09142.11 KOO29762.1 - 0.48 10.3 10.0 17 5.3 0.0 5.3 5 1 0 5 5 5 0 tRNA Pseudouridine synthase II, C terminal GBP_C PF02841.14 KOO29762.1 - 1.1 8.6 10.8 1.7 7.9 10.8 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain HAUS-augmin3 PF14932.6 KOO29762.1 - 1.9 8.0 10.6 3.4 7.2 10.6 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF2201_N PF13203.6 KOO29763.1 - 0.016 14.8 5.1 0.037 13.6 5.1 1.6 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF724 PF05266.14 KOO29763.1 - 1.7 8.4 8.1 0.74 9.6 4.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) CDC37_N PF03234.14 KOO29763.1 - 2.2 9.2 8.0 0.81 10.6 3.0 2.6 2 1 1 3 3 3 0 Cdc37 N terminal kinase binding Med25_SD1 PF11235.8 KOO29763.1 - 5.2 7.4 8.5 6.2 7.1 2.0 2.4 2 0 0 2 2 2 0 Mediator complex subunit 25 synapsin 1 YabA PF06156.13 KOO29763.1 - 5.5 7.7 7.4 0.41 11.3 0.7 2.5 2 1 1 3 3 3 0 Initiation control protein YabA TPH PF13868.6 KOO29764.1 - 1.3e-20 73.2 100.8 1.3e-20 73.2 100.8 2.1 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain PAS PF00989.25 KOO29764.1 - 8.5 6.4 12.3 0.12 12.4 0.5 3.1 3 0 0 3 3 3 0 PAS fold RVT_2 PF07727.14 KOO29765.1 - 4.1e-30 105.2 0.1 4.2e-29 101.9 0.1 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KOO29765.1 - 6.1e-07 29.6 0.0 2.6e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 KOO29765.1 - 0.005 16.7 0.2 0.013 15.3 0.2 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain FAP PF07174.11 KOO29766.1 - 5.6 6.3 26.9 0.14 11.6 20.2 1.7 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) NACHT PF05729.12 KOO29767.1 - 0.00012 22.0 0.1 0.00089 19.2 0.1 2.3 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 KOO29767.1 - 0.0092 16.3 0.0 0.024 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 KOO29767.1 - 0.11 12.0 1.7 0.18 11.3 0.0 2.1 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain G-alpha PF00503.20 KOO29768.1 - 5.4e-89 298.8 0.0 9.6e-89 298.0 0.0 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KOO29768.1 - 4.5e-14 52.3 1.0 4.4e-11 42.5 0.2 2.8 2 0 0 2 2 2 2 ADP-ribosylation factor family Myosin_head PF00063.21 KOO29768.1 - 0.058 11.6 0.3 0.088 11.0 0.3 1.2 1 0 0 1 1 1 0 Myosin head (motor domain) Methyltrn_RNA_3 PF02598.17 KOO29769.1 - 2.4e-70 237.3 0.0 4.4e-45 154.4 0.0 2.1 1 1 1 2 2 2 2 Putative RNA methyltransferase SpoU_methylase PF00588.19 KOO29769.1 - 0.096 12.8 0.0 1 9.5 0.0 2.4 3 0 0 3 3 3 0 SpoU rRNA Methylase family Pro_isomerase PF00160.21 KOO29770.1 - 5.5e-44 150.2 0.2 6.5e-44 150.0 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD EURL PF06937.11 KOO29771.1 - 6.2 6.1 6.8 9.4 5.6 6.8 1.2 1 0 0 1 1 1 0 EURL protein Mito_carr PF00153.27 KOO29772.1 - 1.2e-19 70.0 2.1 5.1e-11 42.4 0.1 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF3535 PF12054.8 KOO29774.1 - 0.086 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) HEAT_2 PF13646.6 KOO29774.1 - 3.3 8.1 16.0 3.6 8.1 7.2 3.4 1 1 0 2 2 2 0 HEAT repeats Kelch_1 PF01344.25 KOO29776.1 - 1.3e-96 316.0 7.6 9.2e-18 63.6 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KOO29776.1 - 1e-57 190.6 0.0 8.2e-11 41.8 0.0 6.1 2 1 4 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KOO29776.1 - 1.4e-52 173.8 0.0 3.5e-11 42.6 0.0 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KOO29776.1 - 1e-40 137.3 3.8 6.7e-07 29.4 0.0 6.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO29776.1 - 4.2e-34 116.3 0.0 2e-05 24.5 0.0 6.1 4 2 2 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO29776.1 - 8.2e-24 83.1 8.7 0.00011 22.1 0.0 6.7 7 0 0 7 7 7 6 Kelch motif PQQ_3 PF13570.6 KOO29776.1 - 9.6e-09 35.5 14.6 1.6 9.3 0.1 5.6 6 0 0 6 6 6 4 PQQ-like domain DciA PF05258.12 KOO29776.1 - 6.3e-08 32.9 0.0 0.14 12.6 0.0 4.6 4 1 1 5 5 5 2 Dna[CI] antecedent, DciA Glyoxal_oxid_N PF07250.11 KOO29776.1 - 2.2e-06 27.1 0.0 0.022 14.0 0.0 3.1 1 1 3 4 4 4 3 Glyoxal oxidase N-terminus DUF134 PF02001.16 KOO29776.1 - 2.7e-06 27.9 0.0 3.6 8.2 0.0 5.0 5 0 0 5 5 5 1 Protein of unknown function DUF134 VLPT PF07122.11 KOO29776.1 - 4.2e-05 23.2 0.0 46 3.8 0.0 5.0 5 0 0 5 5 5 0 Variable length PCR target protein (VLPT) Peptidase_S9_N PF02897.15 KOO29776.1 - 0.00027 19.9 0.0 0.11 11.2 0.0 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF1668 PF07893.13 KOO29776.1 - 0.0013 18.2 4.2 0.9 8.8 0.2 4.2 1 1 4 5 5 5 1 Protein of unknown function (DUF1668) LppX_LprAFG PF07161.13 KOO29776.1 - 0.013 15.4 0.6 5.4 6.8 0.0 3.8 2 1 3 5 5 5 0 LppX_LprAFG lipoprotein Alpha-amyl_C2 PF07821.12 KOO29776.1 - 0.016 15.4 4.5 14 6.0 0.1 4.6 1 1 3 4 4 4 0 Alpha-amylase C-terminal beta-sheet domain Mannosyl_trans4 PF15971.5 KOO29776.1 - 0.075 12.9 3.0 1.2 9.0 0.0 3.5 5 0 0 5 5 5 0 DolP-mannose mannosyltransferase DUF2529 PF10740.9 KOO29776.1 - 0.15 11.7 3.1 36 4.0 0.0 4.1 3 1 2 5 5 5 0 Domain of unknown function (DUF2529) Ion_trans PF00520.31 KOO29777.1 - 4e-193 638.7 55.9 2.4e-53 180.9 0.5 4.0 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO29777.1 - 9e-09 35.0 0.0 2.3e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO29777.1 - 1.7e-06 27.0 79.3 0.00013 20.7 5.4 9.7 8 2 2 10 10 10 8 Polycystin cation channel DUF4834 PF16118.5 KOO29777.1 - 9.8e-05 23.3 0.6 2.2 9.3 0.0 4.3 4 0 0 4 4 4 2 Domain of unknown function (DUF4834) EF-hand_1 PF00036.32 KOO29779.1 - 2.6e-28 95.4 5.1 8.8e-06 24.9 0.0 5.4 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 KOO29779.1 - 9.2e-28 93.8 7.0 1.9e-05 24.2 0.0 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_7 PF13499.6 KOO29779.1 - 2.1e-23 82.5 6.5 5.2e-08 33.2 0.5 3.8 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO29779.1 - 6.6e-17 60.2 11.2 0.0019 17.6 0.1 5.5 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO29779.1 - 9.8e-17 60.6 5.8 7.5e-08 32.1 0.1 4.2 2 2 1 4 4 4 3 EF-hand domain pair Caleosin PF05042.13 KOO29779.1 - 3.1e-05 24.0 0.6 2.3 8.1 0.0 3.7 2 2 2 4 4 4 2 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO29779.1 - 0.00037 20.8 0.2 0.83 10.0 0.0 2.6 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region RHH_1 PF01402.21 KOO29779.1 - 0.017 15.0 2.8 0.084 12.8 0.1 3.1 3 0 0 3 3 3 0 Ribbon-helix-helix protein, copG family EF-hand_9 PF14658.6 KOO29779.1 - 0.018 15.3 0.1 18 5.8 0.0 3.6 3 2 0 3 3 3 0 EF-hand domain Mesd PF10185.9 KOO29779.1 - 0.14 12.1 0.7 0.83 9.6 0.0 2.3 2 1 1 3 3 3 0 Chaperone for wingless signalling and trafficking of LDL receptor LRR_8 PF13855.6 KOO29780.1 - 1.7e-09 37.3 4.4 9.2e-06 25.3 0.2 3.5 1 1 2 3 3 3 3 Leucine rich repeat Ank_2 PF12796.7 KOO29780.1 - 6.3e-09 36.3 0.0 1.4e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO29780.1 - 5.2e-06 26.6 0.0 1.4e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) LRR_4 PF12799.7 KOO29780.1 - 3.4e-05 24.1 7.1 0.012 16.0 0.3 4.1 1 1 4 5 5 5 2 Leucine Rich repeats (2 copies) Ank PF00023.30 KOO29780.1 - 0.00015 22.0 0.0 0.00053 20.3 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 KOO29780.1 - 0.0026 18.1 0.0 0.01 16.3 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.6 KOO29780.1 - 0.0037 17.8 0.0 0.011 16.3 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) LRR_9 PF14580.6 KOO29780.1 - 0.013 15.0 2.6 0.091 12.3 1.0 2.2 1 1 2 3 3 3 0 Leucine-rich repeat Med24_N PF11277.8 KOO29780.1 - 0.026 12.6 0.1 0.039 12.0 0.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal EPF PF17181.4 KOO29780.1 - 0.58 10.2 9.8 1 9.4 7.8 2.2 2 0 0 2 2 2 0 Epidermal patterning factor proteins Carn_acyltransf PF00755.20 KOO29781.1 - 1.7e-56 192.1 0.0 4.2e-29 101.6 0.0 2.0 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase DUF3404 PF11884.8 KOO29781.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) DHC_N1 PF08385.12 KOO29782.1 - 3.2e-158 527.9 13.6 3.2e-158 527.9 13.6 2.7 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 KOO29782.1 - 3.4e-131 437.1 0.1 1.5e-130 435.0 0.0 2.2 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO29782.1 - 8.2e-114 380.8 2.3 1.9e-113 379.6 0.1 3.0 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 KOO29782.1 - 2.4e-87 291.7 0.8 2.2e-86 288.5 2.0 2.1 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 KOO29782.1 - 6.9e-87 291.0 0.0 1.8e-86 289.7 0.0 1.8 2 0 0 2 2 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KOO29782.1 - 6.1e-81 272.0 0.0 1.7e-80 270.5 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 KOO29782.1 - 4.2e-59 199.1 0.6 2.4e-54 183.6 0.0 3.5 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KOO29782.1 - 1.5e-50 171.2 0.1 4.5e-50 169.7 0.1 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 KOO29782.1 - 1.2e-45 156.0 11.4 3.5e-45 154.5 11.4 1.8 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KOO29782.1 - 1.1e-37 128.8 0.0 4.6e-37 126.7 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 KOO29782.1 - 1.5e-20 73.3 4.7 8.3e-20 70.9 0.2 3.5 3 0 0 3 3 3 1 AAA+ lid domain AAA_5 PF07728.14 KOO29782.1 - 5.9e-16 58.7 0.0 0.00023 21.1 0.0 6.2 6 1 0 6 6 5 2 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 KOO29782.1 - 2.4e-14 53.5 0.0 8.4e-14 51.8 0.0 2.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 KOO29782.1 - 6e-07 30.0 0.6 0.063 13.7 0.0 4.7 5 0 0 5 5 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO29782.1 - 8.5e-06 26.3 0.9 0.096 13.1 0.0 4.6 4 0 0 4 4 3 1 AAA ATPase domain AAA_33 PF13671.6 KOO29782.1 - 0.0023 18.1 0.2 0.018 15.2 0.0 2.8 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 KOO29782.1 - 0.003 17.8 2.5 1.7 8.9 0.0 4.6 5 0 0 5 5 3 1 AAA domain AAA_19 PF13245.6 KOO29782.1 - 0.0093 16.3 3.9 1.5 9.1 0.1 3.8 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 KOO29782.1 - 0.014 15.9 1.3 4.7 7.7 0.0 3.5 3 0 0 3 3 2 0 ABC transporter Mg_chelatase PF01078.21 KOO29782.1 - 0.043 13.2 0.0 0.62 9.4 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Cep57_CLD_2 PF14197.6 KOO29782.1 - 0.058 13.5 2.8 0.37 10.9 2.8 2.5 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 RNA_helicase PF00910.22 KOO29782.1 - 0.077 13.4 0.0 3.2 8.2 0.0 3.2 2 0 0 2 2 2 0 RNA helicase MCM PF00493.23 KOO29782.1 - 0.086 11.9 0.6 1.5 7.9 0.0 2.7 3 0 0 3 3 3 0 MCM P-loop domain DUF3846 PF12957.7 KOO29782.1 - 0.088 13.1 0.0 0.38 11.1 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3846) DUF3450 PF11932.8 KOO29782.1 - 0.47 9.7 15.8 2.8 7.2 2.0 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 KOO29782.1 - 0.55 10.0 9.1 5.6 6.7 1.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) AAA_30 PF13604.6 KOO29782.1 - 3 7.5 14.7 5.4 6.7 0.0 4.7 5 0 0 5 5 4 0 AAA domain AAA_29 PF13555.6 KOO29782.1 - 3.9 7.3 5.7 4.4 7.1 0.0 3.5 4 0 0 4 4 4 0 P-loop containing region of AAA domain T6SS_Vgr PF13296.6 KOO29783.1 - 0.00092 19.3 0.9 0.00092 19.3 0.9 1.5 2 0 0 2 2 2 1 Putative type VI secretion system Rhs element Vgr EF-hand_5 PF13202.6 KOO29783.1 - 0.013 15.0 0.0 0.031 13.8 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 KOO29783.1 - 0.034 14.0 0.0 3.7 7.5 0.0 2.8 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_7 PF13499.6 KOO29783.1 - 0.039 14.4 0.0 0.18 12.3 0.0 2.0 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO29783.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain Rep_fac-A_3 PF08661.11 KOO29784.1 - 1.6e-08 34.9 0.0 2.1e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Replication factor A protein 3 Ten1_2 PF15490.6 KOO29784.1 - 0.099 12.4 0.0 0.15 11.8 0.0 1.4 1 1 0 1 1 1 0 Telomere-capping, CST complex subunit FoP_duplication PF13865.6 KOO29786.1 - 3.3 8.3 5.7 7.5 7.2 5.7 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Ribosomal_L5_C PF00673.21 KOO29787.1 - 5.1e-25 87.5 0.0 7.9e-25 86.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 KOO29787.1 - 3.6e-05 24.0 0.0 6.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 MerR_1 PF13411.6 KOO29788.1 - 2e-11 43.8 0.0 3.4 7.8 0.0 12.2 13 1 1 14 14 14 1 MerR HTH family regulatory protein DUF2717 PF10911.8 KOO29788.1 - 5.1e-08 32.5 42.5 0.015 15.0 0.1 12.7 4 2 7 13 13 13 3 Protein of unknown function (DUF2717) MerR-DNA-bind PF09278.11 KOO29788.1 - 9.1e-06 26.1 13.2 31 5.2 0.0 13.3 15 4 2 17 17 17 0 MerR, DNA binding Ribosomal_L13e PF01294.18 KOO29788.1 - 0.00021 21.2 33.9 6.8 6.5 0.2 14.3 6 5 9 18 18 18 2 Ribosomal protein L13e HTH_27 PF13463.6 KOO29788.1 - 0.0029 18.1 0.1 38 4.9 0.0 6.3 7 0 0 7 7 7 0 Winged helix DNA-binding domain AdoMetDC_leader PF08132.11 KOO29788.1 - 0.0047 16.8 15.9 3.1 7.8 0.0 9.0 11 0 0 11 11 11 1 S-adenosyl-l-methionine decarboxylase leader peptide CENP-F_leu_zip PF10473.9 KOO29788.1 - 0.064 13.3 0.6 0.11 12.5 0.6 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Nup54 PF13874.6 KOO29788.1 - 0.24 11.5 1.9 0.52 10.4 1.9 1.5 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 RPAP1_C PF08620.10 KOO29788.1 - 1.1 9.5 30.1 94 3.2 0.0 13.4 10 5 4 14 14 14 0 RPAP1-like, C-terminal DUF4110 PF13422.6 KOO29788.1 - 1.9 8.6 6.9 18 5.5 0.1 4.1 4 0 0 4 4 3 0 Domain of unknown function (DUF4110) Hepsin-SRCR PF09272.10 KOO29788.1 - 6 7.4 7.9 10 6.7 0.5 4.6 3 2 2 5 5 5 0 Hepsin, SRCR domain YmdB PF13277.6 KOO29789.1 - 1.2 8.4 6.0 9.9 5.4 0.2 3.2 3 0 0 3 3 3 0 YmdB-like protein HAD_2 PF13419.6 KOO29791.1 - 1.3e-22 80.8 0.0 6.1e-22 78.6 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO29791.1 - 1.2e-15 58.4 0.1 2.8e-15 57.2 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO29791.1 - 3.5e-07 30.2 0.0 1.3e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like EF-hand_1 PF00036.32 KOO29793.1 - 2.1e-34 114.5 13.2 1.4e-08 33.6 0.0 6.7 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.6 KOO29793.1 - 4.5e-30 103.9 10.6 1.1e-13 51.4 0.2 4.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO29793.1 - 4.3e-27 91.7 11.6 1.2e-07 31.1 0.0 6.7 6 0 0 6 6 6 5 EF-hand domain EF-hand_5 PF13202.6 KOO29793.1 - 2.3e-22 77.4 10.1 0.00017 20.9 0.0 6.3 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO29793.1 - 3.3e-21 74.9 10.9 2.5e-06 27.2 0.3 5.8 5 1 1 6 6 6 5 EF-hand domain pair cNMP_binding PF00027.29 KOO29793.1 - 4.9e-19 68.2 0.1 1.1e-18 67.1 0.1 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_9 PF14658.6 KOO29793.1 - 2.7e-05 24.4 0.3 0.0065 16.8 0.0 3.3 3 1 1 4 4 4 1 EF-hand domain EF-hand_4 PF12763.7 KOO29793.1 - 0.0029 17.5 3.6 1.2 9.1 0.1 4.1 3 1 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 KOO29793.1 - 0.0047 16.9 4.2 4.3 7.2 0.4 4.3 2 1 3 5 5 5 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO29793.1 - 0.022 15.1 1.1 18 5.7 0.0 3.6 4 0 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region DUF853 PF05872.12 KOO29793.1 - 0.086 11.4 0.9 6.4 5.2 0.1 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) DUF3037 PF11236.8 KOO29793.1 - 0.1 13.1 0.0 1.8 9.0 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3037) PNPase PF03726.14 KOO29793.1 - 0.35 11.4 2.8 0.63 10.6 0.2 2.7 3 0 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain EF-hand_10 PF14788.6 KOO29793.1 - 0.49 10.3 3.3 15 5.5 0.1 3.7 4 0 0 4 4 4 0 EF hand Fer2 PF00111.27 KOO29794.1 - 8.5e-08 32.0 1.6 1.2e-07 31.5 1.6 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain ShK PF01549.24 KOO29795.1 - 3.4e-14 53.1 34.9 1.5e-06 28.6 4.2 5.0 5 0 0 5 5 5 3 ShK domain-like 2OG-FeII_Oxy_3 PF13640.6 KOO29795.1 - 3.2e-13 50.4 0.0 6.5e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Mito_fiss_reg PF05308.11 KOO29796.1 - 0.084 12.9 0.3 0.15 12.1 0.3 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 KOO29796.1 - 0.43 10.6 4.3 0.16 12.0 0.9 1.9 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 KOO29796.1 - 1.2 8.6 3.6 1.8 8.0 3.6 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal GBP PF02263.19 KOO29797.1 - 7.2e-34 117.2 0.0 9.7e-32 110.2 0.0 2.3 1 1 1 2 2 2 2 Guanylate-binding protein, N-terminal domain RHD3 PF05879.12 KOO29797.1 - 0.00023 19.5 0.0 0.00034 18.9 0.0 1.2 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 KOO29797.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 KOO29797.1 - 0.15 12.4 6.2 4.6 7.6 3.7 3.4 1 1 1 2 2 2 0 AAA ATPase domain PsbP PF01789.16 KOO29798.1 - 3.1e-24 85.9 0.1 4.2e-24 85.5 0.1 1.1 1 0 0 1 1 1 1 PsbP DOT1 PF08123.13 KOO29799.1 - 7.4e-05 22.4 0.0 0.00013 21.5 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.6 KOO29799.1 - 0.0097 15.7 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO29799.1 - 0.015 16.0 0.0 0.029 15.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 KOO29799.1 - 0.017 15.1 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 KOO29799.1 - 0.03 14.1 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 KOO29799.1 - 0.052 14.2 0.0 0.09 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOO29799.1 - 0.095 12.2 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 KOO29799.1 - 0.16 11.4 0.0 0.32 10.5 0.0 1.4 2 0 0 2 2 2 0 Putative methyltransferase EF-hand_1 PF00036.32 KOO29800.1 - 1.3e-20 71.3 0.3 0.00056 19.3 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO29800.1 - 1.5e-20 71.3 1.0 0.00041 20.1 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO29800.1 - 1.5e-18 67.0 0.3 1.5e-07 31.7 0.0 3.7 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO29800.1 - 4.9e-12 45.5 2.5 4.1e-06 26.6 0.0 4.7 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO29800.1 - 1.7e-06 27.2 6.5 0.088 12.3 0.0 5.1 5 1 1 6 6 6 3 EF hand EF-hand_4 PF12763.7 KOO29800.1 - 0.00066 19.6 0.1 1 9.4 0.0 2.8 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO29800.1 - 0.017 15.5 0.2 15 6.0 0.0 3.3 3 1 2 5 5 5 0 EF-hand domain SMC_N PF02463.19 KOO29801.1 - 9.5e-56 188.7 0.0 3.4e-55 186.9 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOO29801.1 - 3.3e-24 85.4 0.1 6.7e-22 78.0 0.0 3.3 2 1 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 KOO29801.1 - 4.4e-14 53.0 8.2 7.1e-12 45.7 0.0 4.1 2 2 1 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 KOO29801.1 - 1.6e-11 44.6 0.4 3.9e-05 23.6 0.0 2.9 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KOO29801.1 - 1.6e-06 28.8 85.1 0.0067 17.0 44.7 7.1 4 2 0 4 4 4 2 AAA domain AAA_29 PF13555.6 KOO29801.1 - 0.00043 20.0 0.0 0.00097 18.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DEAD PF00270.29 KOO29801.1 - 0.016 15.0 0.7 0.086 12.6 0.0 2.5 3 0 0 3 3 3 0 DEAD/DEAH box helicase EF-hand_5 PF13202.6 KOO29802.1 - 4.3e-16 57.6 1.1 8.1e-07 28.3 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO29802.1 - 3.4e-13 48.4 0.4 1.5e-06 27.7 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO29802.1 - 5.1e-13 47.6 1.3 9.2e-06 24.9 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO29802.1 - 4.8e-12 45.5 0.1 0.00012 21.8 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO29802.1 - 5.9e-11 42.7 0.0 3.1e-10 40.4 0.0 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO29802.1 - 0.068 13.5 0.0 18 5.7 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain ABC_tran PF00005.27 KOO29803.1 - 7.2e-34 117.2 0.0 1.2e-33 116.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOO29803.1 - 2.3e-28 99.6 6.9 4.3e-28 98.7 6.9 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 KOO29803.1 - 9e-08 31.8 0.2 1.4e-05 24.6 0.1 2.5 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KOO29803.1 - 0.0003 21.1 0.1 0.0024 18.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO29803.1 - 0.0011 19.4 0.2 0.0027 18.1 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 KOO29803.1 - 0.0022 17.7 0.2 0.006 16.3 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO29803.1 - 0.0027 17.6 0.1 0.0084 16.0 0.1 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 KOO29803.1 - 0.011 16.3 0.0 0.031 14.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_21 PF13304.6 KOO29803.1 - 0.012 15.4 0.0 0.032 14.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 KOO29803.1 - 0.013 15.1 1.1 0.19 11.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 KOO29803.1 - 0.034 13.5 0.0 0.072 12.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KOO29803.1 - 0.034 14.3 0.0 0.079 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 KOO29803.1 - 0.044 14.0 0.5 1.1 9.6 0.5 2.9 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NTPase_1 PF03266.15 KOO29803.1 - 0.048 13.6 0.4 3.8 7.4 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA PF00004.29 KOO29803.1 - 0.052 14.0 4.5 0.54 10.7 2.1 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO29803.1 - 0.052 13.6 0.2 0.76 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 KOO29803.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 KOO29803.1 - 0.19 11.6 0.1 0.37 10.7 0.1 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain ABC_ATPase PF09818.9 KOO29803.1 - 0.52 9.1 6.4 1.1 8.0 0.2 3.1 4 0 0 4 4 4 0 Predicted ATPase of the ABC class Exo_endo_phos PF03372.23 KOO29805.1 - 1.2e-08 34.8 1.1 1.7e-08 34.3 1.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MORN PF02493.20 KOO29806.1 - 2.9e-39 130.6 43.0 1e-05 25.1 0.6 8.7 8 0 0 8 8 8 8 MORN repeat Mitofilin PF09731.9 KOO29806.1 - 4.8 5.9 4.4 6.8 5.4 4.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF4203 PF13886.6 KOO29807.1 - 0.82 9.3 22.4 6.1 6.5 17.8 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4203) DEAD PF00270.29 KOO29808.1 - 4e-43 147.2 0.0 9.5e-43 146.0 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO29808.1 - 1.4e-24 86.6 0.0 4.7e-24 84.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO29808.1 - 5.6e-05 23.2 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 KOO29808.1 - 0.068 13.1 0.3 0.31 11.0 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain UFD1 PF03152.14 KOO29809.1 - 1.1e-12 47.8 0.0 1.8e-07 30.8 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 UIM PF02809.20 KOO29809.1 - 0.011 15.5 1.3 0.011 15.5 1.3 2.1 2 0 0 2 2 2 0 Ubiquitin interaction motif Neur_chan_memb PF02932.16 KOO29810.1 - 5.1e-07 30.0 3.0 5.1e-07 30.0 3.0 1.7 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DUF1843 PF08898.10 KOO29811.1 - 0.26 11.8 8.0 5.1 7.7 0.3 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) Homeodomain PF00046.29 KOO29813.1 - 8.2e-16 57.6 1.9 1.2e-15 57.1 1.9 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOO29813.1 - 5.7e-05 22.9 0.1 0.0001 22.1 0.1 1.4 1 0 0 1 1 1 1 Homeobox KN domain DNA_mis_repair PF01119.19 KOO29813.1 - 0.085 12.5 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 DNA mismatch repair protein, C-terminal domain DUF4079 PF13301.6 KOO29814.1 - 1.1e-18 67.8 7.7 1.3e-18 67.5 7.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4079) Ni_hydr_CYTB PF01292.20 KOO29814.1 - 0.1 12.2 10.9 0.47 10.0 1.1 2.2 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 UPF0147 PF03685.13 KOO29816.1 - 0.075 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) MRP-S27 PF10037.9 KOO29817.1 - 0.015 14.2 4.8 0.021 13.7 4.8 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 VIT1 PF01988.19 KOO29817.1 - 8 6.3 6.9 11 5.8 6.9 1.2 1 0 0 1 1 1 0 VIT family Ank_5 PF13857.6 KOO29818.1 - 1.1e-08 35.1 4.0 5.3e-06 26.6 0.2 3.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO29818.1 - 1.2e-08 35.5 0.4 5.4e-08 33.3 0.1 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO29818.1 - 3.5e-08 33.8 0.2 3.1e-07 30.8 0.2 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO29818.1 - 0.0001 22.6 11.6 0.0023 18.3 0.3 4.1 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO29818.1 - 0.00014 22.0 0.5 0.018 15.5 0.0 3.5 2 0 0 2 2 2 1 Ankyrin repeat DUF5535 PF17687.1 KOO29818.1 - 0.023 14.8 0.0 0.1 12.8 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5535) TPR_1 PF00515.28 KOO29818.1 - 0.046 13.6 0.3 2.7 7.9 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO29818.1 - 0.55 10.5 3.8 1.3 9.3 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Big_2 PF02368.18 KOO29820.1 - 0.0019 18.0 6.4 0.0082 16.0 0.1 3.7 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 2) Cupin_8 PF13621.6 KOO29821.1 - 1.7e-29 103.3 0.1 2.5e-29 102.8 0.1 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO29821.1 - 0.00033 20.2 0.3 0.0009 18.8 0.3 1.5 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 KOO29821.1 - 0.00084 19.0 0.2 0.0027 17.4 0.2 1.8 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 KOO29821.1 - 0.00095 18.8 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Cupin AAA PF00004.29 KOO29822.1 - 0.00025 21.5 0.0 0.00062 20.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 KOO29822.1 - 0.0014 18.7 0.0 0.0035 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Torsin PF06309.11 KOO29822.1 - 0.0094 16.1 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 1 Torsin AAA_5 PF07728.14 KOO29822.1 - 0.015 15.3 0.0 0.37 10.8 0.0 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO29822.1 - 0.035 14.4 0.0 0.25 11.6 0.0 2.5 2 1 0 2 2 2 0 AAA domain RuvB_N PF05496.12 KOO29822.1 - 0.074 12.8 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 KOO29822.1 - 0.081 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KOO29822.1 - 0.083 13.0 0.4 0.91 9.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain PIF1 PF05970.14 KOO29822.1 - 0.21 10.7 0.0 0.32 10.1 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase AAA_13 PF13166.6 KOO29822.1 - 0.3 9.7 0.0 0.46 9.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain Wbp11 PF09429.10 KOO29823.1 - 3.4e-09 37.0 14.7 6.3e-09 36.1 14.7 1.5 1 1 0 1 1 1 1 WW domain binding protein 11 RIO1 PF01163.22 KOO29825.1 - 3.3e-46 157.3 0.0 5.4e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 KOO29825.1 - 1e-32 112.2 0.1 3.5e-32 110.5 0.1 1.9 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 KOO29825.1 - 1.4e-10 41.5 3.5 7.2e-06 26.1 0.7 3.1 1 1 2 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 KOO29825.1 - 7.1e-05 22.2 0.3 0.013 14.9 0.2 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 KOO29825.1 - 0.0044 16.4 0.6 0.012 15.0 0.6 1.7 1 1 0 1 1 1 1 Protein kinase domain Sulf_transp PF04143.14 KOO29826.1 - 1.6e-09 37.8 42.8 1.4e-05 24.8 9.6 3.6 2 2 1 3 3 3 2 Sulphur transport Glyco_transf_28 PF03033.20 KOO29827.1 - 3.2e-06 27.2 0.0 7.1e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain DUF922 PF06037.11 KOO29827.1 - 0.15 11.9 2.2 0.24 11.2 2.2 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Muted PF14942.6 KOO29827.1 - 0.34 11.3 3.1 0.64 10.4 3.1 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DSBA PF01323.20 KOO29831.1 - 4.9 6.9 6.7 12 5.7 6.7 1.6 1 0 0 1 1 1 0 DSBA-like thioredoxin domain PQQ_2 PF13360.6 KOO29832.1 - 0.039 13.5 0.0 0.13 11.8 0.0 1.9 1 0 0 1 1 1 0 PQQ-like domain TRP PF06011.12 KOO29834.1 - 0.00036 19.4 2.4 0.00073 18.4 2.4 1.4 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel FixH PF05751.11 KOO29834.1 - 0.1 12.6 0.0 2 8.4 0.0 2.8 2 1 1 3 3 3 0 FixH Ank_4 PF13637.6 KOO29835.1 - 0.00058 20.4 0.0 0.0015 19.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO29835.1 - 0.00072 20.1 0.0 0.0014 19.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO29835.1 - 0.024 15.2 0.1 0.14 12.8 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeat DASH_Hsk3 PF08227.11 KOO29837.1 - 0.12 12.7 0.3 0.18 12.2 0.3 1.1 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like ABC_tran_CTD PF16326.5 KOO29837.1 - 0.12 12.6 0.2 0.15 12.4 0.2 1.1 1 0 0 1 1 1 0 ABC transporter C-terminal domain PseudoU_synth_1 PF01416.20 KOO29838.1 - 9.6e-13 48.6 0.0 5.4e-10 39.7 0.0 2.9 3 1 0 3 3 3 2 tRNA pseudouridine synthase DHC_N2 PF08393.13 KOO29839.1 - 3.1e-98 329.5 4.3 3.1e-98 329.5 4.3 1.6 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 Kelch_4 PF13418.6 KOO29839.1 - 7.1e-33 112.4 9.1 2.7e-08 33.7 0.0 7.5 7 0 0 7 7 7 6 Galactose oxidase, central domain AAA_6 PF12774.7 KOO29839.1 - 2.2e-30 105.8 0.8 8e-30 103.9 0.3 2.2 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region Kelch_5 PF13854.6 KOO29839.1 - 3.4e-22 78.0 0.1 0.014 15.4 0.0 7.7 7 0 0 7 7 7 6 Kelch motif Kelch_3 PF13415.6 KOO29839.1 - 6e-22 77.4 15.4 3e-05 24.2 0.0 8.1 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KOO29839.1 - 3.6e-13 48.9 19.9 0.03 14.3 0.1 8.0 8 0 0 8 8 8 5 Kelch motif Kelch_6 PF13964.6 KOO29839.1 - 7.9e-12 45.0 11.0 0.0061 16.8 0.0 7.5 6 1 1 7 7 7 3 Kelch motif Filamin PF00630.19 KOO29839.1 - 5.1e-11 43.3 0.0 1.1e-10 42.3 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat Kelch_1 PF01344.25 KOO29839.1 - 2.2e-10 39.9 10.4 0.072 12.7 0.6 6.6 6 0 0 6 6 6 4 Kelch motif TIG PF01833.24 KOO29839.1 - 3.2e-08 33.5 0.1 1.1e-07 31.9 0.1 2.0 1 0 0 1 1 1 1 IPT/TIG domain Trypan_PARP PF05887.11 KOO29839.1 - 0.015 15.3 15.4 0.032 14.2 15.4 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) HsbA PF12296.8 KOO29839.1 - 0.061 13.8 0.4 0.18 12.2 0.4 1.8 1 0 0 1 1 1 0 Hydrophobic surface binding protein A SPESP1 PF15754.5 KOO29839.1 - 2.6 7.2 4.7 4.4 6.4 4.7 1.2 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Mito_carr PF00153.27 KOO29840.1 - 1.1e-33 115.0 0.9 9.8e-17 60.7 0.0 3.1 1 1 1 3 3 3 3 Mitochondrial carrier protein FKBP_C PF00254.28 KOO29841.1 - 7.7e-16 58.2 0.0 1.4e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase AIG1 PF04548.16 KOO29841.1 - 4e-07 29.6 0.0 5.9e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 AIG1 family FKBP_N PF01346.18 KOO29841.1 - 4.5e-05 24.3 0.0 0.00014 22.8 0.0 1.8 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DUF563 PF04577.14 KOO29842.1 - 8.6e-06 26.0 0.0 1.3e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Hydrolase_6 PF13344.6 KOO29843.1 - 1.6e-12 47.4 0.0 3.2e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO29843.1 - 8.3e-11 41.8 0.0 2e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KOO29843.1 - 3.8e-07 30.6 0.0 0.02 15.2 0.0 2.7 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOO29843.1 - 0.00039 20.6 0.0 0.23 11.5 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 KOO29843.1 - 0.1 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) ADK PF00406.22 KOO29844.1 - 3.8e-54 182.9 0.0 4.5e-54 182.6 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO29844.1 - 1.7e-27 96.5 0.3 3.5e-27 95.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 KOO29844.1 - 3.1e-15 55.8 0.0 7e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 KOO29844.1 - 5.6e-06 26.8 0.5 0.0017 18.7 0.2 2.5 1 1 1 2 2 2 2 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 KOO29844.1 - 0.00017 22.2 0.0 0.00037 21.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 KOO29844.1 - 0.011 15.4 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase AAA_33 PF13671.6 KOO29844.1 - 0.012 15.7 0.0 0.028 14.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 KOO29844.1 - 0.11 13.0 0.1 0.16 12.4 0.1 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 KOO29844.1 - 0.16 11.2 0.1 0.3 10.3 0.1 1.7 1 1 0 1 1 1 0 Zeta toxin SnoaL_2 PF12680.7 KOO29845.1 - 0.014 16.0 0.0 0.017 15.8 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain DUF2358 PF10184.9 KOO29845.1 - 0.12 12.6 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) FACT-Spt16_Nlob PF14826.6 KOO29846.1 - 1.6e-45 154.8 0.4 4.8e-45 153.2 0.0 2.0 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain SPT16 PF08644.11 KOO29846.1 - 5.8e-45 153.2 0.1 5.8e-45 153.2 0.1 2.0 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 KOO29846.1 - 1.4e-26 93.5 0.0 2.4e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 KOO29846.1 - 2.6e-13 50.2 0.0 6.3e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 Histone chaperone Rttp106-like CDC45 PF02724.14 KOO29846.1 - 6 5.0 30.1 0.055 11.8 22.1 1.6 2 0 0 2 2 2 0 CDC45-like protein ADK PF00406.22 KOO29847.1 - 1e-41 142.5 0.0 2.1e-41 141.5 0.0 1.5 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO29847.1 - 5.2e-24 85.2 0.0 1.2e-23 84.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain MORN PF02493.20 KOO29847.1 - 6.3e-14 51.0 35.8 3.9e-08 32.7 1.8 6.3 6 0 0 6 6 6 3 MORN repeat AAA_18 PF13238.6 KOO29847.1 - 1.1e-06 29.2 0.0 3.3e-06 27.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO29847.1 - 0.00015 21.9 0.1 0.00062 19.9 0.0 2.0 2 1 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 KOO29847.1 - 0.034 13.9 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase Hydin_ADK PF17213.3 KOO29847.1 - 0.053 13.8 0.2 0.44 10.8 0.1 2.2 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain BTHB PF18410.1 KOO29848.1 - 8.6e-27 92.8 0.1 1.2e-26 92.3 0.1 1.2 1 0 0 1 1 1 1 Basic tilted helix bundle domain NIF PF03031.18 KOO29849.1 - 5.2e-18 65.3 0.0 8.7e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase LIG3_BRCT PF16759.5 KOO29849.1 - 0.084 13.2 0.1 0.16 12.3 0.1 1.4 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 KOO29849.1 - 0.12 12.3 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 twin BRCT domain zf-PARP PF00645.18 KOO29851.1 - 1.5e-16 61.0 0.2 3.2e-16 59.9 0.2 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WGR PF05406.15 KOO29851.1 - 2.7e-11 43.3 0.2 2.7e-11 43.3 0.2 1.9 2 0 0 2 2 2 1 WGR domain PARP PF00644.20 KOO29851.1 - 4.8e-11 42.6 1.9 6.2e-11 42.3 0.0 2.1 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain SAP PF02037.27 KOO29851.1 - 1.2e-08 34.5 1.9 1.9e-08 33.8 1.0 1.9 2 0 0 2 2 2 1 SAP domain RNA_polI_A34 PF08208.11 KOO29851.1 - 0.17 11.9 20.0 2.6 8.1 18.7 2.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Sec7 PF01369.20 KOO29852.1 - 1.5e-46 158.4 0.0 2.4e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 KOO29852.1 - 4.8e-19 68.8 0.0 9.8e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 PH domain FHA PF00498.26 KOO29852.1 - 5e-11 42.8 0.1 1.7e-10 41.1 0.1 1.9 2 0 0 2 2 2 1 FHA domain PH_11 PF15413.6 KOO29852.1 - 4.3e-08 33.5 0.0 9.8e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Yop-YscD_cpl PF16697.5 KOO29852.1 - 3.7e-05 24.0 0.0 8.4e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PH_6 PF15406.6 KOO29852.1 - 0.0024 18.1 0.2 1.4 9.2 0.0 2.5 1 1 1 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 KOO29852.1 - 0.12 12.7 0.0 1.2 9.5 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain PH_3 PF14593.6 KOO29852.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.7 1 1 0 1 1 1 0 PH domain PH_4 PF15404.6 KOO29852.1 - 0.17 11.7 0.1 3.8 7.3 0.1 2.2 1 1 0 2 2 2 0 Pleckstrin homology domain GLE1 PF07817.13 KOO29853.1 - 0.024 13.8 1.1 0.041 13.1 1.1 1.4 1 0 0 1 1 1 0 GLE1-like protein Lebercilin PF15619.6 KOO29853.1 - 0.088 12.5 11.8 0.22 11.2 11.8 1.6 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease CDH1_2_SANT_HL1 PF18375.1 KOO29853.1 - 1.4 9.7 4.1 2 9.1 1.6 2.5 2 1 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 FAM76 PF16046.5 KOO29853.1 - 7.3 5.8 7.3 8.4 5.6 6.5 1.5 1 1 0 1 1 1 0 FAM76 protein Pkinase PF00069.25 KOO29857.1 - 8.5e-41 140.0 0.0 1.3e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO29857.1 - 6.9e-37 127.1 0.0 1.1e-36 126.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO29857.1 - 0.12 11.6 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like CAP-ZIP_m PF15255.6 KOO29858.1 - 0.21 11.9 10.1 0.77 10.0 0.2 3.3 3 0 0 3 3 3 0 WASH complex subunit CAP-Z interacting, central region PP2C PF00481.21 KOO29859.1 - 3.8e-41 141.4 0.0 5.1e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO29859.1 - 0.00034 20.3 0.8 0.0019 17.9 0.8 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C CheY-binding PF09078.11 KOO29859.1 - 0.032 14.4 0.0 0.064 13.4 0.0 1.5 1 0 0 1 1 1 0 CheY binding Man-6-P_recep PF02157.15 KOO29861.1 - 5.5e-08 32.2 0.0 6.1e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 KOO29861.1 - 7.9e-06 25.9 0.0 1e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 COX14 PF14880.6 KOO29861.1 - 0.14 12.0 0.4 0.3 11.0 0.4 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Guanylate_cyc PF00211.20 KOO29862.1 - 4.6e-15 55.7 0.0 7.1e-07 29.0 0.0 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.6 KOO29862.1 - 2.9e-09 37.5 0.2 5.7e-05 23.6 0.0 3.9 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 KOO29862.1 - 0.012 15.8 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO29862.1 - 0.055 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Bac_DnaA PF00308.18 KOO29862.1 - 0.09 12.6 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein TRAPPC-Trs85 PF12739.7 KOO29863.1 - 0.017 14.1 9.2 8.4 5.2 0.2 4.8 1 1 1 4 4 4 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit MIF PF01187.18 KOO29863.1 - 0.17 12.2 14.6 3.7 7.9 0.2 5.0 3 3 1 5 5 5 0 Macrophage migration inhibitory factor (MIF) Phage_Coat_A PF05357.13 KOO29863.1 - 0.69 9.7 8.5 15 5.5 0.1 5.8 8 0 0 8 8 8 0 Phage Coat Protein A NinD PF17466.2 KOO29865.1 - 0.47 10.6 3.0 1.9 8.6 0.0 3.0 4 0 0 4 4 4 0 Family of unknown function AAA PF00004.29 KOO29866.1 - 2.7e-14 53.7 0.1 2.8e-06 27.8 0.1 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) TIG PF01833.24 KOO29866.1 - 3.2e-13 49.6 0.0 6e-05 23.0 0.0 4.4 3 0 0 3 3 3 3 IPT/TIG domain AAA_lid_6 PF17866.1 KOO29866.1 - 4.1e-06 26.9 0.4 8e-06 26.0 0.4 1.5 1 0 0 1 1 1 1 AAA lid domain AAA_30 PF13604.6 KOO29866.1 - 0.012 15.3 3.5 1.2 8.8 0.2 2.7 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 KOO29866.1 - 0.013 15.5 0.2 4.2 7.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KOO29866.1 - 0.02 15.1 0.2 0.57 10.3 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KOO29866.1 - 0.046 14.0 0.8 1.2 9.4 0.0 2.8 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 KOO29866.1 - 0.046 13.1 0.0 0.38 10.1 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 KOO29866.1 - 0.11 12.8 0.5 4.2 7.6 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_11 PF13086.6 KOO29866.1 - 0.17 11.7 0.0 11 5.7 0.0 3.2 4 0 0 4 4 4 0 AAA domain Torsin PF06309.11 KOO29866.1 - 0.24 11.5 0.0 0.65 10.1 0.0 1.6 1 0 0 1 1 1 0 Torsin Thioredoxin PF00085.20 KOO29867.1 - 6.1e-25 87.2 0.1 8e-25 86.8 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 KOO29867.1 - 1.9e-05 24.8 0.1 3.2e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 KOO29867.1 - 0.00053 19.4 0.0 0.00059 19.3 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KOO29867.1 - 0.0012 19.3 0.1 0.0077 16.7 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOO29867.1 - 0.0028 17.9 0.0 0.0052 17.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 KOO29867.1 - 0.0051 16.6 0.0 0.0081 15.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 KOO29867.1 - 0.014 15.3 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 KOO29867.1 - 0.05 13.3 0.0 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 Redoxin HD_4 PF13328.6 KOO29868.1 - 2.3e-46 157.4 0.3 5.2e-46 156.2 0.3 1.6 1 0 0 1 1 1 1 HD domain RelA_SpoT PF04607.17 KOO29868.1 - 1.3e-27 96.3 0.0 3.3e-27 95.1 0.0 1.7 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins ACT_4 PF13291.6 KOO29868.1 - 6e-09 36.4 1.1 1e-08 35.6 1.1 1.4 1 0 0 1 1 1 1 ACT domain HD PF01966.22 KOO29868.1 - 1.8e-08 34.6 0.2 5.3e-08 33.1 0.0 2.0 2 0 0 2 2 2 1 HD domain TGS PF02824.21 KOO29868.1 - 0.0024 17.9 0.0 0.006 16.6 0.0 1.7 1 0 0 1 1 1 1 TGS domain ThiS PF02597.20 KOO29868.1 - 0.051 14.2 0.0 0.14 12.8 0.0 1.8 1 0 0 1 1 1 0 ThiS family ACT PF01842.25 KOO29868.1 - 0.1 12.4 0.2 0.26 11.1 0.2 1.8 1 0 0 1 1 1 0 ACT domain Apolipoprotein PF01442.18 KOO29868.1 - 0.24 11.2 1.9 1.6 8.5 0.0 2.8 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain EF-hand_5 PF13202.6 KOO29869.1 - 0.00019 20.8 0.2 0.00056 19.3 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO29869.1 - 0.0039 16.6 0.1 0.0093 15.4 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO29869.1 - 0.016 15.1 0.1 0.046 13.7 0.1 1.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.6 KOO29869.1 - 0.018 15.5 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair DUF1707 PF08044.11 KOO29869.1 - 0.1 12.7 0.0 0.35 11.0 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) Methyltransf_21 PF05050.12 KOO29870.1 - 3.9e-07 30.3 0.0 4.3e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain DUF680 PF05079.12 KOO29870.1 - 0.0041 17.8 0.1 0.0073 17.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF680) RNase_P_pop3 PF08228.11 KOO29873.1 - 0.047 13.7 0.3 0.13 12.3 0.1 1.8 2 0 0 2 2 2 0 RNase P subunit Pop3 PDZ_2 PF13180.6 KOO29873.1 - 0.11 12.9 0.2 0.32 11.4 0.1 1.9 2 0 0 2 2 2 0 PDZ domain DUF760 PF05542.11 KOO29876.1 - 5.2e-20 71.6 6.3 2e-12 47.3 0.1 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF760) Kelch_4 PF13418.6 KOO29878.1 - 0.0034 17.4 0.0 0.082 12.9 0.0 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain VASP_tetra PF08776.11 KOO29878.1 - 0.0055 16.2 4.0 0.012 15.1 4.0 1.5 1 0 0 1 1 1 1 VASP tetramerisation domain Filamin PF00630.19 KOO29879.1 - 7.5e-06 26.7 0.0 0.2 12.5 0.0 3.4 4 0 0 4 4 4 2 Filamin/ABP280 repeat PPP4R2 PF09184.11 KOO29879.1 - 0.53 9.8 8.5 0.71 9.4 8.5 1.1 1 0 0 1 1 1 0 PPP4R2 ANAPC15 PF15243.6 KOO29879.1 - 3.1 8.3 10.5 6 7.3 10.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Actin PF00022.19 KOO29880.1 - 1.8e-69 234.3 0.0 5.9e-61 206.3 0.0 2.1 1 1 1 2 2 2 2 Actin NACHT PF05729.12 KOO29882.1 - 1e-05 25.5 0.1 2.8e-05 24.1 0.1 1.8 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 KOO29882.1 - 0.00014 21.5 0.3 0.00027 20.6 0.3 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO29882.1 - 0.0084 16.5 3.1 0.012 16.0 0.3 2.3 2 1 0 2 2 2 1 AAA ATPase domain NPDC1 PF06809.11 KOO29884.1 - 0.0064 15.6 1.7 0.0069 15.5 1.7 1.1 1 0 0 1 1 1 1 Neural proliferation differentiation control-1 protein (NPDC1) Peripla_BP_2 PF01497.18 KOO29885.1 - 0.24 11.0 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein CPSase_L_D2 PF02786.17 KOO29886.1 - 8.6e-54 182.2 0.0 1.3e-53 181.6 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain HMGL-like PF00682.19 KOO29886.1 - 1.2e-31 110.2 0.0 2.4e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 HMGL-like Biotin_carb_C PF02785.19 KOO29886.1 - 1.6e-31 108.6 0.0 3.8e-31 107.4 0.0 1.7 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain PYC_OADA PF02436.18 KOO29886.1 - 3.2e-18 66.2 0.0 7.3e-18 65.0 0.0 1.6 2 0 0 2 2 2 1 Conserved carboxylase domain Dala_Dala_lig_C PF07478.13 KOO29886.1 - 0.00022 20.8 0.0 0.00064 19.3 0.0 1.7 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus MFS_5 PF05631.14 KOO29888.1 - 2.7e-72 243.6 10.7 6.1e-53 180.0 2.8 2.2 1 1 1 2 2 2 2 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 KOO29888.1 - 2.7e-15 56.2 33.3 2.7e-15 56.2 33.3 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Ribosomal_60s PF00428.19 KOO29888.1 - 0.44 11.2 6.6 0.96 10.1 6.6 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF4044 PF13253.6 KOO29888.1 - 2.4 7.7 4.6 0.57 9.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) RAP PF08373.10 KOO29889.1 - 1.8e-14 53.6 0.0 2.7e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 RAP domain DUF1601 PF07671.11 KOO29889.1 - 7e-13 48.2 19.9 0.78 9.7 0.2 8.7 8 0 0 8 8 8 5 Protein of unknown function (DUF1601) FAST_1 PF06743.15 KOO29889.1 - 4.8e-11 42.4 0.0 0.5 10.3 0.0 6.5 1 1 7 8 8 8 5 FAST kinase-like protein, subdomain 1 MTES_1575 PF18741.1 KOO29889.1 - 2.8e-05 24.2 0.0 5.3e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 REase_MTES_1575 FAST_2 PF08368.12 KOO29889.1 - 0.13 13.0 0.0 0.33 11.7 0.0 1.6 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 2 RsdA_SigD_bd PF16751.5 KOO29889.1 - 0.15 12.3 32.4 7.9 6.8 0.4 7.3 7 0 0 7 7 7 0 Anti-sigma-D factor RsdA to sigma factor binding region PGA_cap PF09587.10 KOO29889.1 - 5.1 6.5 10.0 3.2 7.1 1.8 2.5 1 1 1 2 2 2 0 Bacterial capsule synthesis protein PGA_cap NTP_transf_9 PF04248.12 KOO29889.1 - 6.6 6.7 22.2 59 3.7 0.2 6.5 7 0 0 7 7 7 0 Domain of unknown function (DUF427) ShK PF01549.24 KOO29890.1 - 1.7e-08 34.8 23.6 2.8e-07 30.9 3.4 3.8 4 0 0 4 4 4 3 ShK domain-like TetR_C_14 PF17754.1 KOO29892.1 - 0.0093 15.9 1.4 3 7.8 0.1 2.6 2 0 0 2 2 2 2 MftR C-terminal domain DUF2203 PF09969.9 KOO29892.1 - 0.012 16.3 0.1 0.023 15.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Not3 PF04065.15 KOO29892.1 - 0.17 11.3 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component SlyX PF04102.12 KOO29892.1 - 0.22 12.1 3.3 3.1 8.5 0.6 2.6 2 1 1 3 3 3 0 SlyX LRR_6 PF13516.6 KOO29893.1 - 8.6e-58 187.5 27.1 2e-05 24.3 0.0 11.5 11 0 0 11 11 11 11 Leucine Rich repeat LRR_1 PF00560.33 KOO29893.1 - 2.8e-08 33.2 0.0 30 5.7 0.0 9.5 13 0 0 13 13 13 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO29893.1 - 9.3e-07 29.1 18.7 0.14 12.6 0.2 7.4 3 3 4 8 8 8 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO29893.1 - 0.00086 19.0 17.2 2 8.2 0.3 8.0 5 3 1 6 6 6 2 Leucine rich repeat HOASN PF14515.6 KOO29893.1 - 0.029 14.7 24.8 8.2 6.9 0.3 8.8 1 1 7 9 9 9 0 Haem-oxygenase-associated N-terminal helices EIF_2_alpha PF07541.12 KOO29893.1 - 0.046 13.8 1.4 16 5.6 0.7 3.9 1 1 0 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit SpoU_sub_bind PF08032.12 KOO29893.1 - 0.05 13.9 14.3 0.086 13.1 0.1 5.3 5 3 2 7 7 7 0 RNA 2'-O ribose methyltransferase substrate binding DUF2202 PF09968.9 KOO29893.1 - 5.2 6.9 6.1 66 3.3 0.1 4.2 1 1 2 4 4 4 0 Uncharacterized protein domain (DUF2202) SbcCD_C PF13558.6 KOO29894.1 - 0.02 15.1 0.1 0.046 14.0 0.1 1.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 KOO29894.1 - 0.18 11.2 0.0 0.23 10.9 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DPM3 PF08285.11 KOO29895.1 - 0.017 15.3 3.5 11 6.3 0.1 3.0 1 1 2 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF2430 PF10353.9 KOO29895.1 - 0.3 11.5 0.6 47 4.4 0.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2430) DUF5403 PF17395.2 KOO29895.1 - 0.51 10.7 8.3 2.1 8.7 1.1 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5403) LRR_6 PF13516.6 KOO29896.1 - 1.7e-15 55.7 4.6 0.15 12.2 0.0 5.8 5 0 0 5 5 5 5 Leucine Rich repeat LRR_4 PF12799.7 KOO29896.1 - 8.4e-07 29.2 0.6 0.12 12.8 0.1 4.0 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO29896.1 - 6.5e-06 25.8 3.2 0.0052 16.5 0.8 3.9 3 1 0 3 3 3 2 Leucine rich repeat AAA_5 PF07728.14 KOO29897.1 - 1.4e-38 132.0 0.0 5.6e-15 55.6 0.0 5.9 6 0 0 6 6 6 4 AAA domain (dynein-related subfamily) AAA PF00004.29 KOO29897.1 - 4.9e-09 36.7 0.1 1.3e-05 25.6 0.0 4.0 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO29897.1 - 1.8e-08 34.9 6.4 0.00027 21.4 0.1 4.7 4 2 0 4 4 4 2 AAA ATPase domain AAA_3 PF07726.11 KOO29897.1 - 8.8e-08 32.1 0.0 0.00064 19.6 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOO29897.1 - 4.3e-07 30.3 0.0 0.013 15.7 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_33 PF13671.6 KOO29897.1 - 0.00087 19.5 0.0 7 6.8 0.0 3.6 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 KOO29897.1 - 0.0012 18.3 0.0 0.19 11.1 0.0 3.2 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 KOO29897.1 - 0.0017 18.4 0.0 6.4 6.8 0.0 3.4 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 KOO29897.1 - 0.0018 17.8 0.0 15 5.0 0.0 3.9 4 0 0 4 4 4 0 P-loop containing dynein motor region TIP49 PF06068.13 KOO29897.1 - 0.028 13.6 0.1 2.3 7.3 0.0 3.3 4 0 0 4 4 4 0 TIP49 P-loop domain AAA_6 PF12774.7 KOO29897.1 - 0.037 13.0 0.0 8.7 5.2 0.0 3.1 4 0 0 4 4 4 0 Hydrolytic ATP binding site of dynein motor region AAA_18 PF13238.6 KOO29897.1 - 0.064 13.8 0.0 12 6.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 KOO29897.1 - 0.074 13.0 0.0 3.7 7.4 0.0 2.7 3 0 0 3 3 2 0 Rad17 P-loop domain AAA_19 PF13245.6 KOO29897.1 - 0.13 12.6 0.0 2.8 8.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain OmpA PF00691.20 KOO29898.1 - 1.7e-07 31.5 0.0 2.9e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 OmpA family Peptidase_S10 PF00450.22 KOO29899.1 - 4.1e-47 161.5 0.0 2.2e-46 159.1 0.0 2.1 1 1 0 1 1 1 1 Serine carboxypeptidase DNA_pol_B_palm PF14792.6 KOO29899.1 - 1.2e-10 41.6 0.0 3.5e-10 40.1 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 KOO29899.1 - 9.4e-07 28.9 0.0 2.2e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 KOO29899.1 - 3.4e-06 26.8 0.0 0.00021 21.1 0.0 2.4 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda NTP_transf_2 PF01909.23 KOO29899.1 - 0.0059 16.9 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH_8 PF14716.6 KOO29899.1 - 0.043 14.2 0.0 1.9 8.9 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain HHH_5 PF14520.6 KOO29899.1 - 0.059 14.0 0.0 33 5.2 0.0 3.2 3 1 0 4 4 4 0 Helix-hairpin-helix domain HHH PF00633.23 KOO29899.1 - 0.078 12.9 0.1 17 5.5 0.0 3.2 2 0 0 2 2 2 0 Helix-hairpin-helix motif EF-hand_1 PF00036.32 KOO29901.1 - 7.4e-13 47.1 0.3 3.3e-05 23.1 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO29901.1 - 9.1e-10 38.9 2.3 1.3e-09 38.4 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO29901.1 - 2.4e-09 36.9 3.9 4.4e-06 26.4 0.4 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO29901.1 - 3.6e-09 35.8 0.4 0.0026 17.5 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO29901.1 - 1.6e-08 33.6 0.1 0.00084 18.7 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO29901.1 - 2e-05 24.8 0.1 3.5e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO29901.1 - 0.014 15.3 0.2 0.052 13.5 0.2 2.0 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand LANC_like PF05147.13 KOO29902.1 - 8.6e-38 129.8 0.0 1e-37 129.6 0.0 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein SHIPPO-rpt PF07004.12 KOO29903.1 - 0.0014 19.4 3.8 0.014 16.3 1.4 6.5 6 1 0 6 6 6 3 Sperm-tail PG-rich repeat PEP_mutase PF13714.6 KOO29904.1 - 5.4e-41 140.6 0.9 6.6e-41 140.3 0.9 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 KOO29904.1 - 4.8e-10 38.6 0.9 6.1e-10 38.2 0.9 1.1 1 0 0 1 1 1 1 Isocitrate lyase family zinc_ribbon_6 PF14599.6 KOO29906.1 - 3.8e-25 87.7 0.2 3.8e-25 87.7 0.2 4.0 3 1 1 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 KOO29906.1 - 2.8e-17 63.0 19.1 2.8e-17 63.0 19.1 4.0 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 KOO29906.1 - 1.5e-09 38.1 4.7 1.5e-09 38.1 4.7 5.3 4 1 1 5 5 5 1 Ring finger domain zf-RING_UBOX PF13445.6 KOO29906.1 - 1.1e-08 34.9 3.0 1.1e-08 34.9 3.0 4.0 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOO29906.1 - 4.6e-08 32.8 4.0 4.6e-08 32.8 4.0 5.0 4 1 2 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO29906.1 - 1.7e-07 31.0 2.3 1.7e-07 31.0 2.3 4.6 4 2 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO29906.1 - 1.2e-06 28.4 4.6 1.2e-06 28.4 4.6 5.9 3 3 2 5 5 5 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOO29906.1 - 6.6e-06 26.2 4.5 6.6e-06 26.2 4.5 4.8 5 2 1 6 6 6 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 KOO29906.1 - 0.011 15.4 2.4 0.011 15.4 2.4 5.3 4 1 2 6 6 6 0 Zinc-ribbon, C4HC2 type SPRY PF00622.28 KOO29907.1 - 3.3e-20 72.4 0.2 5.9e-11 42.5 0.0 2.4 2 0 0 2 2 2 2 SPRY domain PHD PF00628.29 KOO29907.1 - 0.076 12.9 0.3 0.16 11.9 0.3 1.5 1 0 0 1 1 1 0 PHD-finger Ank_2 PF12796.7 KOO29908.1 - 1e-18 67.7 0.2 2.7e-17 63.1 0.0 2.0 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO29908.1 - 2.2e-16 60.0 0.0 8.4e-06 26.2 0.0 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO29908.1 - 3.9e-14 52.5 0.1 3.6e-09 36.7 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO29908.1 - 1.4e-11 44.3 0.0 0.00086 19.7 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KOO29908.1 - 2.1e-08 33.8 0.1 0.015 15.8 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat HEAT_PBS PF03130.16 KOO29908.1 - 0.045 14.4 1.1 59 4.8 0.1 4.0 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat LMF1 PF06762.14 KOO29910.1 - 3.2e-11 43.0 0.0 3e-09 36.5 0.0 2.2 2 0 0 2 2 2 2 Lipase maturation factor ShK PF01549.24 KOO29910.1 - 0.12 13.0 1.0 0.19 12.3 1.0 1.4 1 0 0 1 1 1 0 ShK domain-like MitoNEET_N PF10660.9 KOO29911.1 - 0.12 12.5 0.1 0.12 12.5 0.1 2.5 3 0 0 3 3 3 0 Iron-containing outer mitochondrial membrane protein N-terminus PKD_channel PF08016.12 KOO29912.1 - 1.6e-08 33.7 0.0 2.8e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Polycystin cation channel DHR10 PF18595.1 KOO29912.1 - 0.0066 16.5 6.3 0.0066 16.5 6.3 2.2 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain CemA PF03040.14 KOO29912.1 - 0.037 14.0 0.1 0.037 14.0 0.1 1.9 2 0 0 2 2 2 0 CemA family Sec34 PF04136.15 KOO29912.1 - 0.14 12.0 4.1 0.28 11.1 4.1 1.5 1 0 0 1 1 1 0 Sec34-like family Med4 PF10018.9 KOO29912.1 - 0.35 10.5 4.5 0.77 9.4 4.5 1.5 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 TMPIT PF07851.13 KOO29912.1 - 0.79 8.9 7.7 0.16 11.2 2.9 1.9 2 0 0 2 2 2 0 TMPIT-like protein DUF1542 PF07564.11 KOO29912.1 - 0.87 9.7 5.6 1.8 8.7 5.6 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) DUF3053 PF11254.8 KOO29912.1 - 7.7 6.0 7.9 0.14 11.8 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3053) UMP1 PF05348.11 KOO29913.1 - 9.4e-26 90.4 0.1 1.1e-25 90.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 ANT PF03374.14 KOO29913.1 - 0.0081 16.5 0.0 0.01 16.1 0.0 1.3 1 0 0 1 1 1 1 Phage antirepressor protein KilAC domain THOC2_N PF16134.5 KOO29914.1 - 0.018 13.7 0.0 0.022 13.4 0.0 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Peptidase_Mx PF15887.5 KOO29915.1 - 0.021 14.2 0.1 0.031 13.7 0.1 1.2 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase DUF1729 PF08354.10 KOO29916.1 - 0.0075 15.2 0.0 0.0095 14.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Ion_trans PF00520.31 KOO29917.1 - 5.9e-193 638.1 56.6 1.1e-56 191.8 0.3 4.0 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO29917.1 - 0.00039 19.2 2.1 0.00039 19.2 2.1 8.8 7 3 3 10 10 10 5 Polycystin cation channel TMEM208_SND2 PF05620.11 KOO29917.1 - 0.013 15.3 0.0 0.68 9.7 0.1 3.1 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 SplA PF11132.8 KOO29917.1 - 0.37 10.6 1.7 0.96 9.3 1.7 1.7 1 0 0 1 1 1 0 Transcriptional regulator protein (SplA) Sec7 PF01369.20 KOO29918.1 - 2.5e-69 232.6 0.2 7e-69 231.2 0.2 1.8 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 KOO29918.1 - 8.6e-42 142.7 14.2 4.7e-41 140.3 4.9 4.0 4 0 0 4 4 4 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 KOO29918.1 - 4.5e-32 111.2 4.5 6e-31 107.5 1.5 3.4 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF1981 PF09324.10 KOO29918.1 - 1.8e-29 101.4 0.3 1.2e-25 89.2 0.0 4.8 4 0 0 4 4 4 2 Domain of unknown function (DUF1981) DUF3583 PF12126.8 KOO29918.1 - 0.0079 15.7 1.9 0.03 13.8 0.1 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3583) B56 PF01603.20 KOO29918.1 - 0.21 10.5 4.2 0.043 12.8 0.5 1.8 2 0 0 2 2 2 0 Protein phosphatase 2A regulatory B subunit (B56 family) Ank_4 PF13637.6 KOO29919.1 - 2e-18 66.5 1.0 1e-13 51.5 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO29919.1 - 3e-16 59.8 0.1 5.5e-16 58.9 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO29919.1 - 4.2e-15 55.6 0.1 1.3e-09 38.1 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO29919.1 - 3.1e-12 45.5 0.1 2.3e-05 24.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KOO29919.1 - 6.6e-10 39.0 0.5 0.00023 21.5 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Enkurin PF13864.6 KOO29919.1 - 3.4 8.2 10.8 0.19 12.2 2.9 2.3 2 0 0 2 2 2 0 Calmodulin-binding SAM_2 PF07647.17 KOO29920.1 - 3.3e-11 43.1 0.0 5.5e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KOO29920.1 - 5.9e-08 33.0 0.0 1e-07 32.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) tRNA_anti-like PF12869.7 KOO29920.1 - 0.037 13.6 0.2 0.11 12.1 0.2 1.7 1 0 0 1 1 1 0 tRNA_anti-like PDEase_I PF00233.19 KOO29921.1 - 8.1e-29 101.0 0.0 1.3e-28 100.3 0.0 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase WD40 PF00400.32 KOO29922.1 - 0.00017 22.3 3.9 0.78 10.7 0.0 4.4 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO29922.1 - 0.0027 18.0 0.0 0.08 13.3 0.0 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain CPSF_A PF03178.15 KOO29922.1 - 0.038 13.3 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 0 CPSF A subunit region Kelch_3 PF13415.6 KOO29923.1 - 3.5e-40 135.6 17.6 2.8e-11 43.4 0.2 7.2 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO29923.1 - 8.4e-36 121.7 19.4 1e-08 35.1 0.0 6.6 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KOO29923.1 - 5.2e-33 112.4 0.1 1.1e-07 31.3 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 KOO29923.1 - 8.4e-30 102.3 0.1 5e-06 26.4 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KOO29923.1 - 1.7e-29 101.1 2.3 3.1e-05 24.1 0.0 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KOO29923.1 - 2.9e-26 90.4 4.9 0.0002 21.2 0.0 6.8 6 1 0 6 6 6 5 Kelch motif zf-RING_2 PF13639.6 KOO29924.1 - 3.6e-13 49.6 2.2 3.6e-13 49.6 2.2 1.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO29924.1 - 3.7e-10 39.5 1.8 3.7e-10 39.5 1.8 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOO29924.1 - 3e-08 33.8 5.4 1.4e-07 31.7 5.4 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KOO29924.1 - 4.8e-08 32.6 0.7 4.8e-08 32.6 0.7 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 KOO29924.1 - 5.6e-07 29.3 0.6 1.2e-06 28.3 0.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO29924.1 - 8.5e-07 28.9 0.3 3.8e-06 26.8 0.1 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOO29924.1 - 6e-06 26.1 0.9 6e-06 26.1 0.9 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KOO29924.1 - 9.4e-06 25.6 0.7 1.8e-05 24.7 0.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KOO29924.1 - 1.9e-05 24.5 1.5 1.9e-05 24.5 1.5 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KOO29924.1 - 0.00071 19.1 1.8 0.0018 17.8 1.8 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 KOO29924.1 - 0.0022 17.8 2.6 0.0055 16.5 2.6 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KOO29924.1 - 0.0033 17.2 2.3 0.0063 16.3 2.3 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 KOO29924.1 - 0.0074 16.4 1.1 0.029 14.5 1.2 2.1 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 KOO29924.1 - 0.068 13.3 5.1 0.87 9.8 5.1 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 KOO29924.1 - 3.1 8.2 6.9 0.53 10.6 1.8 2.3 2 0 0 2 2 2 0 RING-like domain Pex14_N PF04695.13 KOO29924.1 - 5.4 7.7 7.8 47 4.6 5.0 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EMC1_C PF07774.13 KOO29925.1 - 2.2e-59 200.7 0.0 3.2e-59 200.2 0.0 1.3 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 KOO29925.1 - 3.6e-07 30.0 4.2 1.2e-06 28.3 3.9 1.9 1 1 0 1 1 1 1 PQQ-like domain NACHT PF05729.12 KOO29925.1 - 0.00017 21.6 0.1 0.00034 20.6 0.1 1.5 1 0 0 1 1 1 1 NACHT domain CheZ PF04344.13 KOO29925.1 - 0.33 10.8 1.9 0.38 10.6 0.2 1.9 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ Glyco_hydro_2_C PF02836.17 KOO29926.1 - 6.1e-78 262.0 0.0 2.9e-77 259.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 KOO29926.1 - 8.5e-31 107.1 0.0 1.6e-30 106.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 KOO29926.1 - 4.8e-10 39.8 0.0 1.5e-09 38.2 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 KOO29926.1 - 4.3e-07 30.6 0.0 1e-06 29.4 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_72 PF03198.14 KOO29926.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Glucanosyltransferase Bgal_small_N PF02929.17 KOO29926.1 - 0.019 14.6 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 Beta galactosidase small chain Glyco_hydro_42 PF02449.15 KOO29926.1 - 0.14 11.5 0.0 0.38 10.0 0.0 1.6 2 0 0 2 2 2 0 Beta-galactosidase DUF2249 PF10006.9 KOO29927.1 - 0.21 11.5 0.0 23 4.9 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2249) VCBS PF13517.6 KOO29928.1 - 4.1e-122 398.8 135.1 7.5e-14 52.1 4.7 13.1 3 2 10 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO29928.1 - 2.5e-63 209.7 151.7 2.3e-05 24.4 3.9 14.5 14 0 0 14 14 14 14 FG-GAP repeat Dockerin_1 PF00404.18 KOO29928.1 - 6e-21 74.4 37.8 1.8 8.8 0.0 14.1 14 0 0 14 14 14 9 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO29928.1 - 1.8e-06 27.5 69.8 3.1 7.1 0.1 13.9 2 2 10 14 14 14 11 Insecticide toxin TcdB middle/N-terminal region Arrestin_N PF00339.29 KOO29928.1 - 5.9e-06 26.4 0.0 1.4e+02 2.5 0.0 9.2 10 2 1 12 12 12 0 Arrestin (or S-antigen), N-terminal domain BBS1 PF14779.6 KOO29928.1 - 2.2e-05 24.0 12.6 16 4.8 0.0 10.8 13 1 1 14 14 14 1 Ciliary BBSome complex subunit 1 DUF1629 PF07791.11 KOO29928.1 - 0.0013 18.9 0.0 77 3.5 0.0 5.6 6 1 0 7 7 7 0 Protein of unknown function (DUF1629) EF-hand_1 PF00036.32 KOO29928.1 - 0.0086 15.6 61.7 27 4.6 0.1 14.0 14 0 0 14 14 14 0 EF hand EF-hand_5 PF13202.6 KOO29928.1 - 0.63 9.6 98.3 4.4 7.0 0.5 14.5 14 0 0 14 14 14 0 EF hand LpxI_N PF17930.1 KOO29928.1 - 8.7 6.3 5.5 86 3.0 0.0 5.4 12 0 0 12 12 12 0 LpxI N-terminal domain LRR_4 PF12799.7 KOO29929.1 - 1.4e-18 66.7 9.7 0.00022 21.6 0.1 4.6 2 1 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO29929.1 - 2.5e-18 65.6 10.4 5.1e-10 39.0 0.6 3.8 3 1 0 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 KOO29929.1 - 1e-09 37.7 2.5 0.25 11.5 0.0 6.5 6 0 0 6 6 6 3 Leucine Rich repeat LRR_9 PF14580.6 KOO29929.1 - 2.2e-05 24.0 0.2 0.014 14.9 0.0 2.2 2 0 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 KOO29929.1 - 0.00021 21.4 10.6 32 5.6 0.1 7.6 8 1 0 8 8 8 1 Leucine Rich Repeat WD40 PF00400.32 KOO29930.1 - 5.6e-26 90.3 4.5 3.6e-06 27.6 0.0 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO29930.1 - 2.6e-08 34.0 0.0 1.5 9.2 0.0 4.8 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO29930.1 - 0.011 14.7 0.0 4.4 6.2 0.0 3.4 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FLgD_tudor PF13861.6 KOO29930.1 - 0.056 13.7 0.0 0.079 13.2 0.0 1.4 1 0 0 1 1 1 0 FlgD Tudor-like domain EF-hand_6 PF13405.6 KOO29933.1 - 1.6e-55 180.3 25.0 8.2e-05 22.2 0.2 16.1 15 1 1 16 16 16 15 EF-hand domain EF-hand_7 PF13499.6 KOO29933.1 - 6.7e-54 180.2 43.3 2e-09 37.8 0.4 12.2 10 2 1 12 12 12 10 EF-hand domain pair EF-hand_1 PF00036.32 KOO29933.1 - 6.6e-47 153.6 30.9 3.1e-05 23.2 0.2 16.2 16 0 0 16 16 16 14 EF hand EF-hand_8 PF13833.6 KOO29933.1 - 6.6e-19 67.5 50.6 0.0045 16.8 0.2 15.1 12 4 4 16 16 16 8 EF-hand domain pair EF-hand_5 PF13202.6 KOO29933.1 - 2e-16 58.6 36.6 0.0019 17.6 0.0 12.6 14 0 0 14 14 14 5 EF hand EF-hand_9 PF14658.6 KOO29933.1 - 0.00034 20.9 0.2 8.2 6.8 0.0 4.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_10 PF14788.6 KOO29933.1 - 0.14 12.1 17.0 18 5.3 0.1 8.7 8 1 1 9 9 9 0 EF hand EF-hand_4 PF12763.7 KOO29933.1 - 0.52 10.3 30.9 3.2 7.7 0.0 9.6 9 2 2 11 11 11 0 Cytoskeletal-regulatory complex EF hand ThiF PF00899.21 KOO29934.1 - 3.1e-62 210.1 0.0 4.4e-62 209.6 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 KOO29934.1 - 4.1e-05 24.1 0.0 0.00011 22.6 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Sacchrp_dh_NADP PF03435.18 KOO29934.1 - 0.28 11.5 1.2 3 8.1 0.9 2.4 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain RVT_2 PF07727.14 KOO29935.1 - 7.7e-29 101.0 0.0 1.3e-28 100.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KOO29935.1 - 9.4e-05 22.6 0.0 0.00037 20.7 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain C1_2 PF03107.16 KOO29935.1 - 0.00074 19.8 5.6 0.0026 18.0 5.6 2.0 1 0 0 1 1 1 1 C1 domain DUF1336 PF07059.12 KOO29937.1 - 1.1e-34 120.5 0.0 1.6e-34 120.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) PH PF00169.29 KOO29937.1 - 3.5e-06 27.5 0.0 0.22 12.1 0.0 3.0 2 1 0 2 2 2 2 PH domain SNF2_N PF00176.23 KOO29940.1 - 6.7e-56 189.5 0.0 1e-55 188.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_3 PF13920.6 KOO29940.1 - 7.7e-06 25.7 2.1 2e-05 24.3 2.1 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO29940.1 - 1.2e-05 25.3 0.1 1.2e-05 25.3 0.1 1.9 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KOO29940.1 - 1.2e-05 25.5 5.4 3.3e-05 24.1 5.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO29940.1 - 0.0001 22.0 0.8 0.0001 22.0 0.8 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO29940.1 - 0.00016 21.5 3.6 0.00037 20.3 3.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 KOO29940.1 - 0.00022 21.6 0.0 0.00041 20.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 KOO29940.1 - 0.00091 19.1 4.4 0.0019 18.1 4.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Tmpp129 PF10272.9 KOO29940.1 - 0.015 14.6 3.2 0.027 13.8 3.2 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor Zn_ribbon_17 PF17120.5 KOO29940.1 - 0.033 13.8 0.3 0.083 12.5 0.3 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 KOO29940.1 - 0.043 13.6 2.0 0.12 12.1 2.0 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_4 PF14570.6 KOO29940.1 - 0.28 11.0 4.7 0.64 9.9 4.7 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KOO29940.1 - 0.28 11.5 3.0 0.8 10.0 3.0 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOO29940.1 - 0.65 10.1 4.6 3.2 7.9 4.6 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 KOO29940.1 - 1.4 9.2 3.1 2.8 8.2 2.3 1.9 2 0 0 2 2 2 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 KOO29940.1 - 2.4 8.1 12.6 42 4.1 12.9 2.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Filamin PF00630.19 KOO29941.1 - 3.2e-39 133.9 0.0 1.3e-10 42.0 0.0 6.2 6 0 0 6 6 6 5 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO29941.1 - 7.9e-09 35.7 0.0 7.6e-05 23.0 0.0 4.1 5 0 0 5 5 5 2 Invasin, domain 3 EF-hand_1 PF00036.32 KOO29941.1 - 1.3e-07 30.7 0.6 4.6e-07 28.9 0.2 2.1 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO29941.1 - 9.2e-07 29.2 1.3 0.00068 20.0 0.1 1.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO29941.1 - 2e-06 27.2 1.0 6.9e-06 25.6 0.3 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO29941.1 - 1.2e-05 24.6 0.6 3.4e-05 23.1 0.6 1.8 1 0 0 1 1 1 1 EF hand Big_1 PF02369.16 KOO29941.1 - 0.018 15.1 0.0 4.3 7.4 0.0 4.2 4 1 0 4 4 4 0 Bacterial Ig-like domain (group 1) EF-hand_8 PF13833.6 KOO29941.1 - 0.1 12.5 0.4 0.47 10.3 0.2 2.1 1 1 1 2 2 2 0 EF-hand domain pair RPA43_OB PF17875.1 KOO29942.1 - 0.17 12.5 7.8 0.18 12.5 7.8 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I PTPRCAP PF15713.5 KOO29942.1 - 0.18 12.1 17.9 0.25 11.7 17.9 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RPN2_C PF18004.1 KOO29942.1 - 0.24 11.3 5.8 0.24 11.3 5.8 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain NOA36 PF06524.12 KOO29942.1 - 0.31 10.3 21.7 0.39 10.0 21.7 1.3 1 0 0 1 1 1 0 NOA36 protein Pes-10 PF07149.11 KOO29942.1 - 0.33 10.0 21.4 0.38 9.8 21.4 1.0 1 0 0 1 1 1 0 Pes-10 CDC45 PF02724.14 KOO29942.1 - 0.47 8.7 18.6 0.43 8.8 18.6 1.0 1 0 0 1 1 1 0 CDC45-like protein FYDLN_acid PF09538.10 KOO29942.1 - 0.57 10.9 20.3 0.74 10.5 20.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) TFB6 PF17110.5 KOO29942.1 - 0.84 9.4 10.8 0.92 9.2 10.8 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Pox_Ag35 PF03286.14 KOO29942.1 - 0.91 9.3 15.0 1.1 9.0 15.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nop14 PF04147.12 KOO29942.1 - 1.3 7.1 24.2 1.2 7.3 24.2 1.0 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 KOO29942.1 - 1.6 7.6 17.0 1.5 7.7 17.0 1.0 1 0 0 1 1 1 0 Paf1 PPP4R2 PF09184.11 KOO29942.1 - 1.7 8.1 23.9 1.9 8.0 23.9 1.0 1 0 0 1 1 1 0 PPP4R2 eIF-3c_N PF05470.12 KOO29942.1 - 2 6.6 10.5 2 6.6 10.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF2457 PF10446.9 KOO29942.1 - 3.4 6.7 34.4 3.9 6.5 34.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF1115 PF06544.12 KOO29942.1 - 3.7 7.6 8.9 5 7.2 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) Presenilin PF01080.17 KOO29942.1 - 4 6.1 3.9 4 6.1 3.9 1.0 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 KOO29942.1 - 4.9 6.5 23.1 4.8 6.5 23.1 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sporozoite_P67 PF05642.11 KOO29942.1 - 5.9 4.8 13.6 7.2 4.6 13.6 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF913 PF06025.12 KOO29942.1 - 6.1 5.7 6.0 6.1 5.7 6.0 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SDA1 PF05285.12 KOO29942.1 - 7 6.0 25.2 7.5 5.9 25.2 1.0 1 0 0 1 1 1 0 SDA1 V_ATPase_I PF01496.19 KOO29942.1 - 10 3.9 5.9 10 3.9 5.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LysR_substrate PF03466.20 KOO29944.1 - 0.0077 15.6 1.5 0.17 11.2 0.1 2.3 2 0 0 2 2 2 2 LysR substrate binding domain Xpo1 PF08389.12 KOO29945.1 - 0.00046 20.3 0.0 0.00077 19.6 0.0 1.3 1 0 0 1 1 1 1 Exportin 1-like protein Spt4 PF06093.13 KOO29946.1 - 6.5e-20 71.0 0.0 8.8e-20 70.6 0.0 1.2 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.11 KOO29946.1 - 0.00021 21.2 0.0 0.0013 18.6 0.0 1.9 1 1 1 2 2 2 1 Coronavirus gene 5 protein LRR_6 PF13516.6 KOO29947.1 - 1.6e-13 49.5 36.9 0.031 14.3 0.0 12.1 14 0 0 14 14 14 6 Leucine Rich repeat LRR_1 PF00560.33 KOO29947.1 - 6.4e-06 26.0 0.0 14 6.7 0.1 6.2 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_4 PF12799.7 KOO29947.1 - 0.00019 21.8 0.0 31 5.2 0.0 5.8 6 0 0 6 6 6 0 Leucine Rich repeats (2 copies) PikAIV_N PF18605.1 KOO29947.1 - 0.0031 17.1 5.2 43 3.8 0.0 5.2 5 0 0 5 5 5 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain LRR_8 PF13855.6 KOO29947.1 - 0.0052 16.5 0.0 20 5.1 0.0 4.9 6 0 0 6 6 6 1 Leucine rich repeat DUF3197 PF11432.8 KOO29947.1 - 0.012 15.5 0.2 49 3.9 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3197) Adeno_shaft PF00608.17 KOO29947.1 - 0.082 12.7 13.8 6.4 6.7 0.0 6.2 6 0 0 6 6 6 0 Adenoviral fibre protein (repeat/shaft region) PAD_M PF08527.10 KOO29947.1 - 0.12 12.1 5.7 60 3.2 0.0 4.8 4 1 1 5 5 5 0 Protein-arginine deiminase (PAD) middle domain VCBS PF13517.6 KOO29948.1 - 6.5e-85 279.7 78.3 2.4e-13 50.5 5.0 10.3 5 3 5 10 10 10 10 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO29948.1 - 2.6e-50 168.1 135.8 1.9e-05 24.6 1.9 14.0 13 1 1 14 14 14 13 FG-GAP repeat Ephrin_rec_like PF07699.13 KOO29948.1 - 4.8e-16 58.2 51.7 9e-08 31.8 2.3 7.3 4 1 3 7 7 7 4 Putative ephrin-receptor like Dockerin_1 PF00404.18 KOO29948.1 - 0.00066 19.8 42.7 28 5.0 0.1 12.2 13 0 0 13 13 13 3 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO29948.1 - 0.0016 17.8 57.4 1.1 8.6 0.3 12.7 8 2 3 13 13 13 6 Insecticide toxin TcdB middle/N-terminal region DP PF08781.10 KOO29950.1 - 2.5e-37 127.9 0.8 4.7e-37 127.0 0.8 1.4 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.20 KOO29950.1 - 3.7e-24 84.6 0.0 7.8e-24 83.5 0.0 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain CLASP_N PF12348.8 KOO29951.1 - 4.7e-22 78.7 0.0 4e-13 49.5 0.0 2.9 4 0 0 4 4 4 2 CLASP N terminal ATG16 PF08614.11 KOO29951.1 - 0.00035 20.9 3.6 0.00035 20.9 3.6 4.1 3 1 1 4 4 4 1 Autophagy protein 16 (ATG16) Cnd1 PF12717.7 KOO29951.1 - 0.024 14.7 0.1 0.048 13.7 0.1 1.5 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOO29951.1 - 0.07 13.4 0.1 0.07 13.4 0.1 5.5 6 0 0 6 6 6 0 HEAT repeat HEAT_EZ PF13513.6 KOO29951.1 - 0.72 10.4 9.9 0.16 12.5 0.6 4.3 3 0 0 3 3 3 0 HEAT-like repeat Filamin PF00630.19 KOO29952.1 - 1.8e-33 115.4 0.0 4.5e-11 43.5 0.0 6.3 5 1 1 6 6 6 4 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO29952.1 - 6.2e-08 32.8 0.1 0.0026 18.0 0.0 5.0 5 1 0 5 5 5 2 Invasin, domain 3 MORN PF02493.20 KOO29953.1 - 3.8e-56 183.8 54.4 2.6e-08 33.3 1.7 10.8 11 0 0 11 11 11 10 MORN repeat ZZ PF00569.17 KOO29953.1 - 0.01 15.6 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 0 Zinc finger, ZZ type DUF3048_C PF17479.2 KOO29953.1 - 4.8 7.6 19.5 18 5.8 0.2 5.8 1 1 6 7 7 7 0 Protein of unknown function (DUF3048) C-terminal domain DUF1330 PF07045.11 KOO29953.1 - 7.4 7.0 6.2 13 6.2 0.0 4.3 3 2 2 6 6 6 0 Domain of unknown function (DUF1330) SAP PF02037.27 KOO29956.1 - 1.8e-05 24.4 0.8 3.8e-05 23.3 0.8 1.5 1 0 0 1 1 1 1 SAP domain FA_desaturase PF00487.24 KOO29957.1 - 6.7e-31 108.0 11.8 9.8e-31 107.5 11.8 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 KOO29957.1 - 1.4e-08 34.7 0.0 3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain EF-hand_1 PF00036.32 KOO29958.1 - 1.6e-10 39.8 4.3 2.1e-05 23.8 0.3 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO29958.1 - 3.3e-10 39.0 1.3 0.00048 19.8 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO29958.1 - 4.2e-09 36.7 1.3 8.8e-09 35.7 1.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO29958.1 - 1.1e-07 31.0 1.0 0.003 17.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO29958.1 - 7.7e-07 28.9 1.2 0.00041 20.1 0.3 2.6 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO29958.1 - 0.0061 16.9 0.1 0.014 15.7 0.1 1.6 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO29958.1 - 0.072 13.1 1.5 0.59 10.1 1.3 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 KOO29958.1 - 0.11 13.4 0.0 0.2 12.6 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain SecA_DEAD PF07517.14 KOO29959.1 - 1.3e-11 44.4 0.0 3e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain ResIII PF04851.15 KOO29959.1 - 0.083 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit WD40 PF00400.32 KOO29960.1 - 1.1e-12 48.2 0.6 0.0035 18.1 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO29960.1 - 2.5e-10 40.5 0.0 0.00054 20.2 0.0 3.5 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KOO29960.1 - 0.08 13.5 3.5 23 5.6 0.0 4.6 5 0 0 5 5 5 0 PQQ-like domain RAB3GAP2_N PF14655.6 KOO29960.1 - 0.16 11.2 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DOT1 PF08123.13 KOO29961.1 - 4.4e-07 29.6 0.0 8.4e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 Complex1_LYR_2 PF13233.6 KOO29962.1 - 1.1e-05 26.1 0.0 1.3e-05 25.8 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like FAM199X PF15814.5 KOO29963.1 - 4.7 6.2 5.4 5.5 6.0 5.4 1.0 1 0 0 1 1 1 0 Protein family FAM199X VMA21 PF09446.10 KOO29963.1 - 9.1 6.5 7.7 0.27 11.4 1.6 1.6 2 0 0 2 2 2 0 VMA21-like domain LRR_5 PF13306.6 KOO29964.1 - 7.7e-107 352.4 0.0 5.6e-31 107.2 0.0 4.7 2 1 1 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO29964.1 - 7.6e-18 64.0 0.0 1.5 8.6 0.0 12.0 6 4 8 14 14 14 7 Leucine rich repeat SpoVAB PF13782.6 KOO29964.1 - 0.0015 18.8 7.9 23 5.3 0.2 6.8 2 2 6 8 8 8 1 Stage V sporulation protein AB IBR PF01485.21 KOO29964.1 - 0.065 13.5 0.1 0.065 13.5 0.1 3.6 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain Herpes_UL21 PF03252.13 KOO29964.1 - 0.11 11.2 0.8 1.1e+02 1.4 0.0 4.6 4 1 2 6 6 6 0 Herpesvirus UL21 TylF PF05711.11 KOO29966.1 - 3.3e-46 157.7 0.0 4.4e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 KOO29966.1 - 3.5e-08 34.4 0.0 7.5e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ank_4 PF13637.6 KOO29967.1 - 3.4e-28 97.6 4.2 7e-08 32.9 0.0 5.0 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO29967.1 - 8.5e-28 96.8 0.1 1.1e-09 38.8 0.3 3.6 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 KOO29967.1 - 8.1e-19 67.2 0.0 0.021 15.3 0.0 6.8 6 1 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 KOO29967.1 - 5.7e-18 64.7 7.9 0.00012 22.3 0.1 6.0 3 3 3 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO29967.1 - 6.3e-17 59.9 2.0 0.045 14.3 0.0 7.4 7 0 0 7 7 7 3 Ankyrin repeat TylF PF05711.11 KOO29968.1 - 8.2e-30 103.9 0.0 1.3e-29 103.3 0.0 1.3 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 KOO29968.1 - 4e-05 24.6 0.0 8.9e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Agenet PF05641.12 KOO29970.1 - 0.039 14.4 0.1 0.2 12.2 0.0 2.1 2 0 0 2 2 2 0 Agenet domain UCH PF00443.29 KOO29971.1 - 1.8e-06 27.6 0.0 2.4e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 KOO29971.1 - 0.25 11.1 0.0 0.96 9.3 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin family zf-RING_2 PF13639.6 KOO29972.1 - 1.5e-09 38.0 2.0 3.2e-09 37.0 2.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KOO29972.1 - 2.8e-07 30.4 1.7 5.5e-07 29.4 1.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOO29972.1 - 5.1e-07 29.5 1.5 1e-06 28.5 1.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO29972.1 - 6.8e-07 29.2 1.5 1.5e-06 28.2 1.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 KOO29972.1 - 3.3e-05 23.5 2.4 6.5e-05 22.6 2.4 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 KOO29972.1 - 0.00019 21.2 1.2 0.00042 20.1 1.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO29972.1 - 0.00096 19.0 6.2 0.0058 16.5 6.2 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KOO29972.1 - 0.0015 18.2 0.3 0.0045 16.7 0.3 1.8 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KOO29972.1 - 0.003 17.8 2.8 0.0083 16.4 2.8 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KOO29972.1 - 0.0032 17.6 2.4 0.023 14.8 2.4 2.2 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_1 PF14446.6 KOO29972.1 - 0.0076 16.2 0.5 0.0076 16.2 0.5 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 Prok-RING_4 PF14447.6 KOO29972.1 - 0.013 15.4 1.9 0.38 10.7 2.4 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF4129 PF13559.6 KOO29972.1 - 0.033 14.4 0.4 0.067 13.5 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) zf-ANAPC11 PF12861.7 KOO29972.1 - 0.06 13.4 0.8 0.19 11.8 0.8 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn-C2H2_12 PF18112.1 KOO29972.1 - 0.063 13.8 1.1 12 6.5 0.0 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Rtf2 PF04641.12 KOO29972.1 - 0.12 11.7 1.6 0.41 10.0 0.1 1.9 1 1 1 2 2 2 0 Rtf2 RING-finger Heme_oxygenase PF01126.20 KOO29973.1 - 5.9e-59 199.3 0.1 7.1e-59 199.0 0.1 1.1 1 0 0 1 1 1 1 Heme oxygenase CpeT PF06206.11 KOO29974.1 - 6e-22 78.5 0.0 7.7e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 CpeT/CpcT family (DUF1001) Flu_C_NS2 PF03555.14 KOO29974.1 - 0.0065 16.6 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Influenza C non-structural protein (NS2) TIR_2 PF13676.6 KOO29975.1 - 6.4e-17 62.2 0.0 2.5e-08 34.5 0.0 2.9 2 0 0 2 2 2 2 TIR domain Proteasom_PSMB PF10508.9 KOO29975.1 - 2.5e-05 23.0 1.5 0.046 12.2 0.0 3.8 3 0 0 3 3 3 2 Proteasome non-ATPase 26S subunit DUF3636 PF12331.8 KOO29975.1 - 0.0071 16.2 0.3 0.34 10.7 0.0 3.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3636) Arm PF00514.23 KOO29975.1 - 0.034 14.2 30.3 0.73 10.0 0.0 12.1 15 0 0 15 15 15 0 Armadillo/beta-catenin-like repeat TIR PF01582.20 KOO29975.1 - 0.25 11.1 0.0 21 4.9 0.1 2.5 2 0 0 2 2 2 0 TIR domain NiFe-hyd_HybE PF11939.8 KOO29975.1 - 0.67 9.8 3.6 1.5 8.7 0.8 3.3 2 1 0 2 2 2 0 [NiFe]-hydrogenase assembly, chaperone, HybE AAA PF00004.29 KOO29977.1 - 0.0017 18.8 0.2 0.0028 18.1 0.2 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 KOO29977.1 - 0.06 13.1 1.7 0.2 11.4 0.0 2.1 1 1 0 2 2 2 0 DEAD/DEAH box helicase PRKCSH-like PF12999.7 KOO29979.1 - 2.6e-22 79.4 8.9 5.8e-22 78.3 8.9 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 KOO29979.1 - 5e-16 58.8 0.0 1.7e-15 57.0 0.0 1.8 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 KOO29979.1 - 0.027 15.5 0.0 0.053 14.5 0.0 1.5 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein ATG27 PF09451.10 KOO29979.1 - 0.028 14.3 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 Autophagy-related protein 27 Chromo PF00385.24 KOO29981.1 - 4.8e-11 42.4 0.2 1.3e-10 41.1 0.2 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PRO8NT PF08082.11 KOO29981.1 - 0.048 13.6 3.5 1.7 8.6 0.3 2.9 3 0 0 3 3 3 0 PRO8NT (NUC069), PrP8 N-terminal domain Topoisom_bac PF01131.20 KOO29982.1 - 7.4e-87 292.0 0.0 2e-60 205.0 0.0 2.0 1 1 1 2 2 2 2 DNA topoisomerase Toprim PF01751.22 KOO29982.1 - 1.7e-18 66.8 0.0 2.9e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Toprim domain SAP PF02037.27 KOO29982.1 - 5.2e-10 38.8 0.5 1.2e-09 37.7 0.5 1.6 1 0 0 1 1 1 1 SAP domain Toprim_4 PF13662.6 KOO29982.1 - 0.04 14.4 0.0 0.47 10.9 0.0 2.8 3 1 0 3 3 3 0 Toprim domain DNA_binding_1 PF01035.20 KOO29982.1 - 0.091 12.9 1.8 2.9 8.1 0.0 3.3 2 1 1 3 3 3 0 6-O-methylguanine DNA methyltransferase, DNA binding domain HeH PF12949.7 KOO29982.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 HeH/LEM domain DUF4326 PF14216.6 KOO29983.1 - 0.00028 21.6 0.0 0.00028 21.6 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4326) Exo_endo_phos PF03372.23 KOO29983.1 - 0.063 12.8 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 KOO29983.1 - 0.19 11.2 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) NAD_binding_8 PF13450.6 KOO29984.1 - 5.6e-11 42.5 1.3 8.2e-11 42.0 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO29984.1 - 0.0059 16.2 0.1 0.013 15.1 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 KOO29984.1 - 0.04 13.2 3.4 1.9 7.7 0.4 2.3 1 1 1 2 2 2 0 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 KOO29984.1 - 0.053 13.5 0.0 0.13 12.2 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding PARP PF00644.20 KOO29985.1 - 5.7e-15 55.4 0.0 6.9e-15 55.2 0.0 1.2 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Exotox-A_cataly PF09009.10 KOO29985.1 - 0.0053 16.5 0.0 0.007 16.1 0.0 1.2 1 0 0 1 1 1 1 Exotoxin A catalytic InvH PF04741.12 KOO29987.1 - 0.11 12.4 1.3 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 InvH outer membrane lipoprotein ABC_membrane PF00664.23 KOO29988.1 - 5.6e-17 62.3 6.9 5.6e-17 62.3 6.9 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOO29988.1 - 7.5e-12 45.9 0.0 1.7e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter UBA PF00627.31 KOO29989.1 - 3.3e-06 26.9 0.1 8.7e-06 25.5 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Ras PF00071.22 KOO29989.1 - 0.00019 21.0 0.0 0.00031 20.4 0.0 1.4 1 0 0 1 1 1 1 Ras family CUE PF02845.16 KOO29989.1 - 0.048 13.4 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 CUE domain cobW PF02492.19 KOO29991.1 - 5.1e-05 22.9 0.0 6.1e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain HisKA_2 PF07568.12 KOO29992.1 - 0.16 12.1 0.9 0.29 11.3 0.9 1.4 1 0 0 1 1 1 0 Histidine kinase SAP PF02037.27 KOO29993.1 - 6e-08 32.3 1.7 1.1e-07 31.4 1.7 1.4 1 0 0 1 1 1 1 SAP domain BID PF06393.11 KOO29993.1 - 0.039 13.5 1.3 0.068 12.7 1.3 1.3 1 0 0 1 1 1 0 BH3 interacting domain (BID) Ank_5 PF13857.6 KOO29995.1 - 4.8e-10 39.5 0.2 1.4e-09 38.0 0.2 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO29995.1 - 3.6e-09 37.0 0.1 1.3e-05 25.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO29995.1 - 6e-07 30.0 0.0 1.4e-06 28.8 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO29995.1 - 1e-05 25.7 0.1 0.0003 21.1 0.1 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 KOO29995.1 - 0.0025 18.1 0.0 0.054 14.1 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat SAP PF02037.27 KOO29995.1 - 0.18 11.6 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 SAP domain Glyco_hydro_2_C PF02836.17 KOO29996.1 - 5.4e-78 262.2 0.0 2.7e-77 259.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 KOO29996.1 - 7.8e-31 107.2 0.0 1.5e-30 106.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 KOO29996.1 - 4.4e-10 39.9 0.0 1.4e-09 38.3 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 KOO29996.1 - 4e-07 30.7 0.0 8.6e-07 29.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_72 PF03198.14 KOO29996.1 - 0.01 15.1 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 Glucanosyltransferase Glyco_hydro_42 PF02449.15 KOO29996.1 - 0.13 11.6 0.0 0.36 10.1 0.0 1.6 2 0 0 2 2 2 0 Beta-galactosidase zf-RING_2 PF13639.6 KOO29997.1 - 1.7e-13 50.7 2.2 1.7e-13 50.7 2.2 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO29997.1 - 1.7e-10 40.5 1.8 1.7e-10 40.5 1.8 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOO29997.1 - 2.4e-08 33.6 0.7 2.4e-08 33.6 0.7 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 KOO29997.1 - 9.1e-08 32.3 5.9 9.1e-08 32.3 5.9 2.3 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KOO29997.1 - 2.8e-07 30.4 0.3 1.8e-06 27.9 0.1 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOO29997.1 - 5.7e-07 29.3 0.6 5.7e-07 29.3 0.6 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO29997.1 - 2.8e-06 27.2 0.9 2.8e-06 27.2 0.9 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KOO29997.1 - 4.3e-06 26.7 0.6 8.2e-06 25.8 0.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KOO29997.1 - 8.4e-06 25.6 1.5 8.4e-06 25.6 1.5 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO29997.1 - 0.00085 19.1 1.1 0.00085 19.1 1.1 1.7 2 1 0 2 2 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 KOO29997.1 - 0.00086 18.9 1.8 0.00086 18.9 1.8 1.7 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 KOO29997.1 - 0.0029 17.4 2.3 0.0029 17.4 2.3 1.5 2 0 0 2 2 1 1 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 KOO29997.1 - 0.03 14.5 5.8 0.65 10.2 5.8 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 KOO29997.1 - 0.03 14.5 2.2 0.03 14.5 2.2 2.3 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Prok-RING_1 PF14446.6 KOO29997.1 - 0.15 12.0 1.4 18 5.3 0.3 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 RINGv PF12906.7 KOO29997.1 - 0.16 12.1 2.2 0.53 10.4 2.2 1.9 1 1 0 1 1 1 0 RING-variant domain zinc_ribbon_16 PF17034.5 KOO29997.1 - 0.3 11.3 1.4 0.63 10.3 0.2 2.0 2 0 0 2 2 2 0 Zinc-ribbon like family zf-RING-like PF08746.11 KOO29997.1 - 1 9.7 6.4 0.21 12.0 1.5 2.1 2 0 0 2 2 2 0 RING-like domain CSN8_PSD8_EIF3K PF10075.9 KOO29998.1 - 1.4e-21 77.0 0.0 1.8e-21 76.6 0.0 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family DUF563 PF04577.14 KOO29999.1 - 2.2e-10 41.0 0.0 3.3e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Bclx_interact PF08945.10 KOO30001.1 - 0.02 14.7 0.7 5.5 6.8 0.2 2.6 2 0 0 2 2 2 0 Bcl-x interacting, BH3 domain 2OG-FeII_Oxy_3 PF13640.6 KOO30004.1 - 2.6e-07 31.4 0.0 5.1e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO30004.1 - 0.0079 16.7 0.0 0.012 16.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 KOO30004.1 - 0.096 12.9 0.0 3.1 8.0 0.1 2.1 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) Lactamase_B_4 PF13691.6 KOO30005.1 - 1.7e-05 24.4 0.0 3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 tRNase Z endonuclease DNA_pol_phi PF04931.13 KOO30005.1 - 4.8 5.2 4.8 6.2 4.8 4.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi PSI_PSAK PF01241.18 KOO30006.1 - 4e-08 33.1 8.6 7.5e-08 32.3 3.0 2.3 2 1 0 2 2 2 2 Photosystem I psaG / psaK Disulph_isomer PF06491.11 KOO30006.1 - 0.088 12.9 1.3 0.17 12.0 1.0 1.5 1 1 1 2 2 2 0 Disulphide isomerase Lactamase_B_2 PF12706.7 KOO30007.1 - 3.7e-17 62.5 1.9 1.7e-07 31.0 0.1 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KOO30007.1 - 9.3e-05 22.5 2.9 9.5e-05 22.5 1.0 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily DUF2188 PF09954.9 KOO30007.1 - 0.049 13.8 0.9 0.63 10.2 0.1 3.0 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) Alanine_zipper PF11839.8 KOO30007.1 - 5.6 7.4 7.9 19 5.7 7.9 1.9 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein SPRY PF00622.28 KOO30008.1 - 1.5e-07 31.5 0.0 2.3e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 SPRY domain Succ_CoA_lig PF13607.6 KOO30009.1 - 0.19 11.5 0.1 0.19 11.5 0.1 1.9 2 1 1 3 3 3 0 Succinyl-CoA ligase like flavodoxin domain LRR_8 PF13855.6 KOO30010.1 - 1.1e-12 47.6 4.2 2.5e-05 23.9 0.1 3.6 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 KOO30010.1 - 4.9e-12 45.9 0.1 0.00018 21.8 0.1 3.4 2 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO30010.1 - 6.7e-11 42.0 0.0 1.3e-09 37.8 0.0 2.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 KOO30010.1 - 0.055 13.5 2.8 38 4.7 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 KOO30010.1 - 0.24 12.1 0.5 1.6e+02 3.5 0.0 4.2 5 1 0 5 5 5 0 Leucine Rich Repeat DUF4407 PF14362.6 KOO30010.1 - 1.9 7.8 11.2 2.9 7.2 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YlqD PF11068.8 KOO30011.1 - 0.17 12.2 2.2 0.25 11.7 1.0 1.7 1 1 0 1 1 1 0 YlqD protein UPF0242 PF06785.11 KOO30011.1 - 0.18 11.9 3.3 0.31 11.1 3.4 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 KOO30011.1 - 0.85 9.9 8.5 1.4 9.1 0.5 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding OEP PF02321.18 KOO30011.1 - 1.6 8.5 26.6 2.4 7.9 8.9 2.1 1 1 1 2 2 2 0 Outer membrane efflux protein APG6_N PF17675.1 KOO30011.1 - 4.7 7.7 17.2 8.1 7.0 6.3 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region ubiquitin PF00240.23 KOO30012.1 - 7.2e-07 28.9 0.0 9.4e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOO30012.1 - 0.00018 21.3 0.0 0.00029 20.6 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 KOO30012.1 - 0.0072 16.4 0.0 0.0084 16.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Nuc_sug_transp PF04142.15 KOO30013.1 - 1.4e-65 221.5 2.5 1.7e-65 221.3 2.5 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO30013.1 - 0.001 19.2 6.5 0.001 19.2 6.5 2.7 2 1 0 2 2 2 1 EamA-like transporter family PUNUT PF16913.5 KOO30013.1 - 0.0077 15.5 1.2 0.0077 15.5 1.2 2.3 3 0 0 3 3 3 1 Purine nucleobase transmembrane transport Presenilin PF01080.17 KOO30014.1 - 0.2 10.4 11.7 0.29 9.8 11.7 1.2 1 0 0 1 1 1 0 Presenilin GAGA_bind PF06217.12 KOO30014.1 - 0.69 10.1 8.6 0.95 9.7 8.6 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Exonuc_VII_L PF02601.15 KOO30014.1 - 0.82 9.2 15.5 1.5 8.4 15.5 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit GREB1 PF15782.5 KOO30014.1 - 2 5.5 7.9 2.3 5.2 7.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S46 PF10459.9 KOO30014.1 - 9.5 4.7 14.7 13 4.3 14.7 1.1 1 0 0 1 1 1 0 Peptidase S46 PHD PF00628.29 KOO30015.1 - 0.0015 18.3 3.6 0.0015 18.3 3.6 3.1 2 1 0 2 2 2 1 PHD-finger SHOCT PF09851.9 KOO30015.1 - 0.068 12.9 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Short C-terminal domain LBR_tudor PF09465.10 KOO30015.1 - 0.095 12.5 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain zf-RING_9 PF13901.6 KOO30015.1 - 0.29 11.1 8.4 0.62 10.0 8.4 1.5 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-HC5HC2H_2 PF13832.6 KOO30015.1 - 0.54 10.4 6.5 1.6 8.9 6.5 1.9 1 0 0 1 1 1 0 PHD-zinc-finger like domain SpoU_methylase PF00588.19 KOO30016.1 - 2.9e-15 56.7 0.0 3.9e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family Isochorismatase PF00857.20 KOO30017.1 - 4.7e-25 88.8 0.2 1.1e-24 87.5 0.2 1.7 1 1 0 1 1 1 1 Isochorismatase family EF-hand_1 PF00036.32 KOO30017.1 - 2.8e-09 35.9 1.1 0.00025 20.3 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO30017.1 - 1.8e-07 30.5 0.3 0.0061 16.4 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO30017.1 - 7.2e-07 29.6 0.2 3.1e-06 27.6 0.3 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO30017.1 - 9.4e-07 28.1 0.1 0.0018 17.7 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO30017.1 - 0.0028 17.5 0.8 0.015 15.1 0.5 2.3 2 1 1 3 3 3 1 EF-hand domain pair RIIa PF02197.17 KOO30017.1 - 0.0037 16.9 0.0 0.0085 15.7 0.0 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit SPARC_Ca_bdg PF10591.9 KOO30017.1 - 0.063 13.6 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region HipN PF18253.1 KOO30017.1 - 0.076 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Hsp70-interacting protein N N-terminal domain Filamin PF00630.19 KOO30018.1 - 5.8e-24 84.9 0.0 3.6e-19 69.5 0.0 2.1 2 0 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO30018.1 - 1.1e-06 28.9 0.0 2.9e-06 27.5 0.0 1.6 2 0 0 2 2 2 1 Invasin, domain 3 Big_3_5 PF16640.5 KOO30018.1 - 0.037 14.2 0.2 0.06 13.5 0.2 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) Big_6 PF17936.1 KOO30018.1 - 0.039 14.2 0.3 3.7 7.9 0.1 2.4 1 1 1 2 2 2 0 Bacterial Ig domain BclA_C PF18573.1 KOO30018.1 - 0.08 12.9 0.3 0.53 10.2 0.3 2.0 1 1 1 2 2 2 0 BclA C-terminal domain Big_1 PF02369.16 KOO30018.1 - 0.09 12.8 0.2 0.18 11.9 0.2 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) DUF5011 PF16403.5 KOO30018.1 - 0.11 12.6 0.3 0.19 11.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5011) DUF775 PF05603.12 KOO30019.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) PSK_trans_fac PF07704.11 KOO30020.1 - 3.3 8.5 5.7 2.1 9.2 0.2 3.0 3 1 0 3 3 3 0 Rv0623-like transcription factor DUF4821 PF16092.5 KOO30022.1 - 8.5e-76 255.1 0.0 2.2e-68 230.7 0.0 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF4821) Pyr_redox_2 PF07992.14 KOO30022.1 - 2.1e-08 33.8 0.0 2.7e-07 30.1 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO30022.1 - 0.034 14.7 0.7 0.53 10.9 0.0 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF4407 PF14362.6 KOO30022.1 - 7.4 5.8 14.5 13 5.0 14.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EF-hand_6 PF13405.6 KOO30023.1 - 1e-50 165.3 31.3 3.4e-05 23.4 0.0 12.3 12 0 0 12 12 12 11 EF-hand domain EF-hand_1 PF00036.32 KOO30023.1 - 1.3e-46 152.7 44.8 0.00013 21.2 0.2 12.7 13 0 0 13 13 13 12 EF hand EF-hand_7 PF13499.6 KOO30023.1 - 3.1e-45 152.5 27.5 1.3e-08 35.1 0.1 7.0 6 1 0 6 6 6 6 EF-hand domain pair EF-hand_8 PF13833.6 KOO30023.1 - 2.9e-26 91.1 38.0 5.5e-08 32.5 0.0 10.1 6 6 6 12 12 12 9 EF-hand domain pair EF-hand_5 PF13202.6 KOO30023.1 - 4.8e-25 85.9 33.3 0.00059 19.2 0.1 11.5 11 0 0 11 11 11 6 EF hand p25-alpha PF05517.12 KOO30023.1 - 6.9e-07 29.6 4.8 3.5 7.8 0.4 5.1 4 1 1 5 5 5 3 p25-alpha EF-hand_9 PF14658.6 KOO30023.1 - 4.2e-06 27.0 0.0 6.6 7.1 0.0 5.4 5 1 1 6 6 5 1 EF-hand domain Caleosin PF05042.13 KOO30023.1 - 0.0012 18.7 5.4 4.8 7.1 0.0 5.1 4 1 1 5 5 5 2 Caleosin related protein EF-hand_14 PF17959.1 KOO30023.1 - 0.0018 18.6 3.6 1e+02 3.3 0.0 6.4 6 1 1 7 7 6 0 EF-hand domain Toprim_2 PF13155.6 KOO30023.1 - 0.0056 17.1 1.2 34 5.0 0.0 4.7 4 1 1 5 5 5 0 Toprim-like EF-hand_4 PF12763.7 KOO30023.1 - 0.0074 16.2 27.6 5.9 6.9 0.3 9.0 6 3 5 11 11 11 2 Cytoskeletal-regulatory complex EF hand Tcp11 PF05794.13 KOO30023.1 - 0.015 14.4 0.0 0.37 9.8 0.0 2.2 2 0 0 2 2 2 0 T-complex protein 11 TolB_N PF04052.13 KOO30023.1 - 0.088 13.0 0.0 25 5.1 0.0 2.7 2 0 0 2 2 2 0 TolB amino-terminal domain Hormone_6 PF00236.18 KOO30023.1 - 0.13 12.2 0.1 29 4.7 0.0 2.5 2 0 0 2 2 2 0 Glycoprotein hormone SPARC_Ca_bdg PF10591.9 KOO30023.1 - 0.18 12.1 14.8 4 7.8 0.2 6.3 4 3 3 7 7 7 0 Secreted protein acidic and rich in cysteine Ca binding region RST PF12174.8 KOO30023.1 - 0.38 10.7 2.7 50 3.9 0.0 4.0 4 1 1 5 5 5 0 RCD1-SRO-TAF4 (RST) plant domain UPF0158 PF03682.13 KOO30023.1 - 0.4 10.7 3.6 0.73 9.8 0.2 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0158) TERF2_RBM PF16772.5 KOO30023.1 - 0.69 9.4 3.0 22 4.6 0.2 3.2 3 0 0 3 3 3 0 Telomeric repeat-binding factor 2 Rap1-binding motif TUDOR PF00567.24 KOO30025.1 - 4.7e-08 33.1 0.6 1.7e-07 31.3 0.0 2.1 2 1 0 2 2 2 1 Tudor domain SMN PF06003.12 KOO30025.1 - 4.9e-05 22.7 0.1 4.9e-05 22.7 0.1 2.6 1 1 1 2 2 2 1 Survival motor neuron protein (SMN) Agenet PF05641.12 KOO30025.1 - 0.0013 19.2 0.0 0.091 13.2 0.0 2.5 2 0 0 2 2 2 1 Agenet domain Chromo PF00385.24 KOO30026.1 - 6.4e-09 35.6 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Acetyltransf_7 PF13508.7 KOO30027.1 - 0.001 19.5 0.0 0.002 18.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO30027.1 - 0.003 17.5 0.0 0.0045 16.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO30027.1 - 0.016 15.4 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family SET PF00856.28 KOO30027.1 - 0.017 15.5 0.0 0.027 14.9 0.0 1.3 1 0 0 1 1 1 0 SET domain LRR_6 PF13516.6 KOO30028.1 - 1.5e-15 55.8 0.4 0.018 15.0 0.1 4.5 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.7 KOO30028.1 - 0.00029 21.2 0.0 0.072 13.5 0.0 2.9 2 2 0 2 2 2 2 Leucine Rich repeats (2 copies) Ccdc124 PF06244.12 KOO30032.1 - 7.8e-28 97.6 1.1 9.3e-28 97.4 1.1 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 DUF3126 PF11324.8 KOO30032.1 - 0.024 14.5 0.1 0.049 13.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3126) FliS_cochap PF16522.5 KOO30032.1 - 0.089 12.7 0.2 0.14 12.1 0.2 1.2 1 0 0 1 1 1 0 Flagellar FLiS export co-chaperone, HP1076 YABBY PF04690.13 KOO30032.1 - 0.22 12.1 1.2 0.36 11.4 1.2 1.5 1 1 0 1 1 1 0 YABBY protein Melibiase_2 PF16499.5 KOO30033.1 - 1.1e-15 57.6 1.1 2.4e-11 43.4 0.9 2.4 2 1 0 2 2 2 2 Alpha galactosidase A Glyco_hydro_97 PF10566.9 KOO30033.1 - 0.0044 16.4 0.0 0.007 15.7 0.0 1.2 1 0 0 1 1 1 1 Glycoside hydrolase 97 Glyco_hydro_2 PF00703.21 KOO30034.1 - 1.6e-06 28.8 4.3 3.5e-06 27.6 0.0 3.1 2 2 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 KOO30034.1 - 6.5e-06 25.5 0.2 0.0026 16.9 0.2 2.9 2 1 0 2 2 2 2 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 KOO30034.1 - 0.00022 21.2 0.0 0.00074 19.5 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain GDI PF00996.18 KOO30035.1 - 8.1e-152 505.7 0.0 1e-151 505.4 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Aminotran_1_2 PF00155.21 KOO30036.1 - 5.2e-39 134.4 0.0 6.5e-39 134.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KOO30036.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase FKBP_C PF00254.28 KOO30037.1 - 5.9e-58 193.2 0.1 1.1e-27 96.2 0.0 2.3 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 KOO30037.1 - 5.4e-05 23.0 0.1 0.002 18.1 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO30037.1 - 0.0001 22.0 0.1 0.0017 18.1 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO30037.1 - 0.016 15.3 0.6 0.03 14.5 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30037.1 - 0.019 15.8 0.4 0.1 13.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30037.1 - 0.021 15.0 0.0 0.076 13.3 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO30037.1 - 0.079 13.3 0.0 0.55 10.6 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO30037.1 - 0.091 13.4 0.0 0.7 10.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO30037.1 - 0.13 11.9 0.2 0.71 9.6 0.0 2.2 2 0 0 2 2 2 0 TPR repeat Aldose_epim PF01263.20 KOO30038.1 - 1.2e-74 251.3 0.0 1.5e-74 251.1 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Tad PF13400.6 KOO30038.1 - 0.026 14.8 0.6 0.051 13.9 0.6 1.4 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like Nrap PF03813.14 KOO30039.1 - 2.6e-13 50.3 0.1 4.8e-12 46.2 0.1 2.2 2 0 0 2 2 2 1 Nrap protein domain 1 Nrap_D2 PF17403.2 KOO30039.1 - 4.2e-08 33.1 0.3 8.3e-08 32.1 0.3 1.5 1 0 0 1 1 1 1 Nrap protein PAP/OAS-like domain Pribosyltran_N PF13793.6 KOO30040.1 - 2e-47 159.9 0.0 1.2e-46 157.4 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 KOO30040.1 - 1.5e-28 100.1 0.1 8.1e-28 97.7 0.1 2.0 1 1 0 2 2 2 1 Phosphoribosyl synthetase-associated domain SPX PF03105.19 KOO30040.1 - 3.8e-18 66.6 9.4 5.6e-08 33.1 0.0 3.1 2 1 1 3 3 3 3 SPX domain Pribosyltran PF00156.27 KOO30040.1 - 2.1e-09 37.1 0.1 1.1e-08 34.7 0.1 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase domain Arfaptin PF06456.13 KOO30041.1 - 0.045 13.3 0.2 0.057 13.0 0.2 1.1 1 0 0 1 1 1 0 Arfaptin-like domain Syntaxin-6_N PF09177.11 KOO30041.1 - 0.061 13.9 0.2 0.097 13.2 0.2 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Speriolin_N PF15058.6 KOO30041.1 - 0.33 11.0 5.3 0.62 10.1 5.3 1.5 1 1 0 1 1 1 0 Speriolin N terminus ABC1 PF03109.16 KOO30042.1 - 8.3e-32 109.9 0.1 1.8e-31 108.7 0.1 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO30042.1 - 0.0082 16.1 0.2 0.28 11.1 0.2 2.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family DNA_pol3_chi PF04364.13 KOO30042.1 - 0.13 12.4 0.8 0.32 11.1 0.1 1.9 2 0 0 2 2 2 0 DNA polymerase III chi subunit, HolC UPF0160 PF03690.13 KOO30043.1 - 1.3e-100 337.2 0.0 1.9e-100 336.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) DUF2914 PF11141.8 KOO30043.1 - 0.15 11.9 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) SpoU_methylase PF00588.19 KOO30044.1 - 1.9e-34 118.9 0.0 2.8e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 KOO30044.1 - 0.005 17.1 0.0 0.017 15.4 0.0 1.9 2 0 0 2 2 2 1 RNA 2'-O ribose methyltransferase substrate binding Pro_isomerase PF00160.21 KOO30046.1 - 1.3e-44 152.3 0.3 1.6e-44 152.0 0.3 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Tubulin PF00091.25 KOO30047.1 - 7.5e-66 222.1 0.0 9.9e-66 221.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 KOO30047.1 - 0.025 14.3 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain LSM PF01423.22 KOO30048.1 - 1.3e-18 66.5 0.8 1.6e-18 66.2 0.8 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 KOO30048.1 - 0.043 14.0 1.0 0.071 13.2 0.4 1.7 1 1 1 2 2 2 0 RimP C-terminal SH3 domain SM-ATX PF14438.6 KOO30048.1 - 0.073 13.2 0.1 0.095 12.9 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Metallophos PF00149.28 KOO30049.1 - 0.0039 17.7 0.0 0.005 17.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ank_4 PF13637.6 KOO30051.1 - 5.2e-05 23.7 0.4 0.026 15.1 0.1 1.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO30051.1 - 0.00046 20.7 0.2 0.00068 20.2 0.2 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) TGS PF02824.21 KOO30051.1 - 0.026 14.5 0.1 0.082 13.0 0.0 1.9 2 0 0 2 2 2 0 TGS domain Ank_5 PF13857.6 KOO30051.1 - 0.052 13.9 0.1 0.34 11.3 0.0 2.2 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Aminotran_1_2 PF00155.21 KOO30052.1 - 3e-18 66.2 0.0 3.5e-18 65.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 KOO30052.1 - 0.0036 16.2 0.0 0.0059 15.4 0.0 1.3 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Beta_elim_lyase PF01212.21 KOO30052.1 - 0.0064 15.8 0.0 0.0086 15.4 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KOO30052.1 - 0.019 14.3 0.1 0.46 9.7 0.0 2.3 3 0 0 3 3 3 0 DegT/DnrJ/EryC1/StrS aminotransferase family ExsD PF16806.5 KOO30053.1 - 0.03 14.2 6.9 0.041 13.8 6.9 1.2 1 0 0 1 1 1 0 Antiactivator protein ExsD UPF0767 PF15990.5 KOO30053.1 - 0.67 10.1 5.9 1.6 8.9 0.8 2.4 2 0 0 2 2 2 0 UPF0767 family CCDC50_N PF15295.6 KOO30053.1 - 1.3 9.1 36.6 0.088 13.0 7.5 3.9 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 50 N-terminus AAA PF00004.29 KOO30054.1 - 1.9e-38 131.9 0.0 3e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 KOO30054.1 - 1.9e-21 75.8 0.0 7.1e-21 74.0 0.0 2.0 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 KOO30054.1 - 8.6e-09 35.1 0.0 1e-07 31.6 0.0 2.6 2 1 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 KOO30054.1 - 8.1e-08 32.2 0.0 1.3e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO30054.1 - 4e-07 30.6 0.2 0.00029 21.3 0.0 2.6 1 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KOO30054.1 - 5.9e-06 26.5 0.0 9.3e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOO30054.1 - 6.5e-06 26.5 0.3 0.0072 16.6 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 KOO30054.1 - 4.7e-05 23.4 0.1 0.00057 19.9 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KOO30054.1 - 0.00024 20.9 0.0 0.00039 20.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 KOO30054.1 - 0.0003 20.1 0.0 0.00061 19.1 0.0 1.3 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 KOO30054.1 - 0.00033 20.8 0.0 0.0015 18.7 0.0 2.1 2 1 1 3 3 2 1 AAA domain AAA_25 PF13481.6 KOO30054.1 - 0.0012 18.5 0.5 0.56 9.8 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_24 PF13479.6 KOO30054.1 - 0.0014 18.4 0.0 0.003 17.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO30054.1 - 0.002 18.7 0.0 0.0034 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOO30054.1 - 0.0038 17.6 0.0 0.0063 16.9 0.0 1.4 1 0 0 1 1 1 1 RNA helicase DUF815 PF05673.13 KOO30054.1 - 0.0039 16.4 0.0 0.0058 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Bac_DnaA PF00308.18 KOO30054.1 - 0.0058 16.5 0.0 0.013 15.4 0.0 1.7 1 1 0 1 1 1 1 Bacterial dnaA protein AAA_14 PF13173.6 KOO30054.1 - 0.0059 16.6 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KOO30054.1 - 0.014 14.8 0.1 0.048 13.0 0.1 1.8 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 KOO30054.1 - 0.018 15.0 0.1 0.09 12.7 0.1 2.0 1 1 0 1 1 1 0 NACHT domain AAA_17 PF13207.6 KOO30054.1 - 0.019 15.4 0.0 0.035 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KOO30054.1 - 0.021 14.8 0.0 0.17 11.8 0.0 1.9 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 KOO30054.1 - 0.029 14.4 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 KOO30054.1 - 0.033 13.3 0.0 0.055 12.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 KOO30054.1 - 0.039 13.8 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KOO30054.1 - 0.049 13.2 0.0 0.13 11.7 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 KOO30054.1 - 0.068 13.4 0.1 0.17 12.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOO30054.1 - 0.09 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KOO30054.1 - 0.12 11.8 0.1 0.25 10.8 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.6 KOO30054.1 - 0.18 12.1 0.3 0.84 10.0 0.2 2.0 1 1 1 2 2 2 0 AAA domain AAA_30 PF13604.6 KOO30054.1 - 0.18 11.5 1.4 0.43 10.3 0.1 2.2 2 1 0 2 2 2 0 AAA domain Myb_DNA-bind_5 PF13873.6 KOO30055.1 - 0.0074 16.3 0.1 0.0077 16.3 0.1 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF737 PF05300.11 KOO30056.1 - 3.7 7.8 7.0 7.3 6.9 7.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF737) Acetyltransf_1 PF00583.25 KOO30057.1 - 0.073 13.3 0.0 0.084 13.1 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOO30057.1 - 0.1 12.5 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KOO30057.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase ABC1 PF03109.16 KOO30059.1 - 7.2e-25 87.5 0.1 2.5e-24 85.7 0.0 1.9 2 0 0 2 2 2 1 ABC1 family Pkinase PF00069.25 KOO30059.1 - 0.2 11.0 0.0 14 5.0 0.0 2.4 2 0 0 2 2 2 0 Protein kinase domain Ion_trans PF00520.31 KOO30060.1 - 3.8e-34 118.0 16.8 4.8e-34 117.7 16.8 1.1 1 0 0 1 1 1 1 Ion transport protein Abhydrolase_2 PF02230.16 KOO30060.1 - 6.5e-09 35.9 0.2 4e-06 26.8 0.0 2.2 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase PIH1_CS PF18201.1 KOO30060.1 - 9.4e-05 22.8 0.0 0.00021 21.6 0.0 1.6 1 0 0 1 1 1 1 PIH1 CS-like domain Peptidase_S9 PF00326.21 KOO30060.1 - 0.0051 16.3 0.0 0.0086 15.6 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 KOO30060.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family PKD_channel PF08016.12 KOO30060.1 - 0.014 14.1 12.5 0.052 12.2 2.7 2.3 2 0 0 2 2 2 0 Polycystin cation channel Ion_trans PF00520.31 KOO30061.1 - 1.6e-37 129.1 16.9 2e-37 128.7 16.9 1.1 1 0 0 1 1 1 1 Ion transport protein EF-hand_1 PF00036.32 KOO30061.1 - 0.00083 18.7 0.0 0.0031 16.9 0.0 2.1 1 0 0 1 1 1 1 EF hand PKD_channel PF08016.12 KOO30061.1 - 0.0013 17.5 19.7 0.069 11.8 9.9 2.5 2 1 0 2 2 2 2 Polycystin cation channel EF-hand_7 PF13499.6 KOO30061.1 - 0.0026 18.2 0.0 0.0063 16.9 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO30061.1 - 0.047 13.6 0.0 0.23 11.5 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 KOO30061.1 - 0.06 12.9 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 EF hand PP-binding PF00550.25 KOO30062.1 - 6.1e-13 48.9 0.0 9.7e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 KOO30062.1 - 1.5e-05 25.4 0.0 2.9e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension TPR_12 PF13424.6 KOO30063.1 - 1.4e-40 137.5 29.5 2.7e-14 53.2 2.0 4.5 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 KOO30063.1 - 3.4e-32 109.4 23.9 4.7e-09 35.8 0.3 6.7 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOO30063.1 - 1.8e-22 78.1 7.2 4.6e-06 26.2 0.1 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO30063.1 - 1.6e-14 52.8 18.2 0.0002 21.2 0.1 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOO30063.1 - 2.6e-13 49.0 9.9 0.038 14.0 0.0 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30063.1 - 5.9e-11 41.7 3.4 0.032 14.4 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO30063.1 - 3.6e-10 39.7 17.5 5.3e-08 32.6 4.9 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_16 PF13432.6 KOO30063.1 - 4.7e-08 33.6 16.2 0.033 14.8 3.2 5.1 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO30063.1 - 2.9e-07 30.9 10.3 0.0093 16.5 0.9 4.3 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_4 PF07721.14 KOO30063.1 - 1.4e-06 28.3 5.4 0.024 15.2 0.5 4.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30063.1 - 2.7e-05 24.6 20.4 0.077 13.9 0.5 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 KOO30063.1 - 9.4e-05 21.8 2.8 0.0015 18.0 0.1 3.2 4 0 0 4 4 4 1 SHNi-TPR SNAP PF14938.6 KOO30063.1 - 0.0033 16.9 1.4 0.4 10.1 0.2 2.5 1 1 2 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 KOO30063.1 - 0.0053 16.4 6.7 3.6 7.3 0.1 4.4 4 0 0 4 4 4 2 TPR repeat PI3K_P85_iSH2 PF16454.5 KOO30063.1 - 0.0088 15.7 0.1 2.1 7.9 0.1 2.7 1 1 1 2 2 2 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TPR_17 PF13431.6 KOO30063.1 - 0.026 14.9 0.1 58 4.4 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Vps35 PF03635.17 KOO30063.1 - 0.054 12.0 0.0 0.074 11.5 0.0 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 35 TPR_3 PF07720.12 KOO30063.1 - 0.21 11.6 1.2 33 4.6 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat His_Phos_1 PF00300.22 KOO30064.1 - 3.7e-11 43.1 0.2 3.4e-07 30.1 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF4129 PF13559.6 KOO30065.1 - 0.029 14.6 12.3 1.5 9.1 0.2 4.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4129) HEAT_EZ PF13513.6 KOO30065.1 - 0.043 14.3 1.4 0.39 11.3 1.4 2.9 1 0 0 1 1 1 0 HEAT-like repeat DM PF00751.18 KOO30066.1 - 0.066 13.1 0.7 0.13 12.2 0.7 1.5 1 0 0 1 1 1 0 DM DNA binding domain Chordopox_RPO7 PF05864.12 KOO30066.1 - 0.43 10.9 2.2 1.6 9.0 0.3 2.7 2 1 1 3 3 3 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) WD40 PF00400.32 KOO30068.1 - 6.7e-24 83.7 13.7 7.6e-07 29.7 0.0 5.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO30068.1 - 1.1e-14 54.4 1.0 0.0019 18.4 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO30068.1 - 1.9e-06 27.1 1.9 0.0012 17.9 0.0 3.4 1 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOO30068.1 - 2e-05 24.6 0.0 0.029 14.2 0.0 2.7 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A LIFR_N PF18207.1 KOO30068.1 - 0.0063 16.9 2.0 0.01 16.2 0.6 2.0 2 0 0 2 2 2 1 Leukemia inhibitory factor receptor N-terminal domain Nup160 PF11715.8 KOO30068.1 - 0.081 11.6 0.9 1.2 7.7 0.3 2.2 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Mg-por_mtran_C PF07109.11 KOO30068.1 - 0.12 12.8 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium-protoporphyrin IX methyltransferase C-terminus Methyltransf_23 PF13489.6 KOO30069.1 - 0.0093 15.8 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO30069.1 - 0.072 13.8 0.0 0.12 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SAYSvFN PF10260.9 KOO30072.1 - 5.7e-13 48.6 0.0 8.6e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) ubiquitin PF00240.23 KOO30072.1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin family Peptidase_S8 PF00082.22 KOO30073.1 - 3.7e-14 52.7 0.6 6.2e-14 52.0 0.6 1.3 1 0 0 1 1 1 1 Subtilase family DCP1 PF06058.13 KOO30074.1 - 2.1e-39 134.1 0.0 2.9e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family RRP7 PF12923.7 KOO30074.1 - 0.021 14.9 0.0 0.038 14.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Ran_BP1 PF00638.18 KOO30074.1 - 0.1 12.9 0.0 4.4 7.6 0.0 2.2 2 0 0 2 2 2 0 RanBP1 domain TFIIB PF00382.19 KOO30075.1 - 6.3e-32 109.5 0.8 7.3e-16 58.0 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 KOO30075.1 - 6.2e-14 51.2 3.0 1.1e-13 50.4 3.0 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding BRF1 PF07741.13 KOO30075.1 - 0.00032 21.0 0.5 0.00032 21.0 0.5 1.8 2 0 0 2 2 2 1 Brf1-like TBP-binding domain DUF1204 PF06721.11 KOO30075.1 - 0.0081 15.6 3.3 0.014 14.8 2.6 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1204) TackOD1 PF18551.1 KOO30075.1 - 0.043 13.5 1.4 0.12 12.1 1.4 1.7 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Kri1 PF05178.12 KOO30075.1 - 0.058 14.0 4.5 0.11 13.1 4.5 1.5 1 0 0 1 1 1 0 KRI1-like family OrfB_Zn_ribbon PF07282.11 KOO30075.1 - 0.14 12.1 1.9 0.31 11.0 1.9 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DZR PF12773.7 KOO30075.1 - 0.14 12.2 2.5 0.34 11.0 2.5 1.6 1 0 0 1 1 1 0 Double zinc ribbon Auto_anti-p27 PF06677.12 KOO30075.1 - 0.26 11.5 3.4 0.49 10.6 3.4 1.5 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) CDC37_N PF03234.14 KOO30075.1 - 0.65 10.9 3.6 0.42 11.5 1.5 1.8 2 0 0 2 2 1 0 Cdc37 N terminal kinase binding zf-ribbon_3 PF13248.6 KOO30075.1 - 2.3 7.8 9.0 1.4e+02 2.0 9.0 2.5 1 1 0 1 1 1 0 zinc-ribbon domain Prim_Zn_Ribbon PF08273.12 KOO30075.1 - 4.2 7.7 8.1 2.7 8.4 5.7 1.9 2 1 0 2 2 1 0 Zinc-binding domain of primase-helicase zinc_ribbon_2 PF13240.6 KOO30075.1 - 4.3 7.2 7.4 22 4.9 0.0 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Caudo_TAP PF02413.17 KOO30075.1 - 7.9 6.6 8.8 3 8.0 6.1 1.7 2 1 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK EF-hand_1 PF00036.32 KOO30076.1 - 2.2e-28 95.6 11.1 1.8e-06 27.1 0.3 6.1 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.6 KOO30076.1 - 5.4e-28 94.5 10.6 7.4e-06 25.5 0.1 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.6 KOO30076.1 - 1.4e-25 89.5 0.9 1.7e-06 28.4 0.0 5.3 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO30076.1 - 3.5e-24 83.2 16.5 1.1e-06 27.8 0.1 5.9 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO30076.1 - 3.6e-24 84.4 3.4 2.9e-06 27.0 0.3 5.0 4 1 0 4 4 4 4 EF-hand domain pair Caleosin PF05042.13 KOO30076.1 - 0.01 15.8 0.3 3.7 7.4 0.0 3.3 2 1 2 4 4 4 0 Caleosin related protein dCache_2 PF08269.11 KOO30076.1 - 0.028 13.6 0.0 1.2 8.2 0.0 2.1 2 0 0 2 2 2 0 Cache domain SPARC_Ca_bdg PF10591.9 KOO30076.1 - 0.065 13.6 0.0 53 4.2 0.0 3.7 4 0 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region LMP PF04778.12 KOO30076.1 - 0.088 12.7 0.1 0.27 11.1 0.0 1.8 3 0 0 3 3 3 0 LMP repeated region DUF5486 PF17588.2 KOO30076.1 - 0.12 12.2 1.5 22 5.1 0.0 3.9 4 0 0 4 4 4 0 Family of unknown function (DUF5486) Peptidase_S8 PF00082.22 KOO30078.1 - 5e-26 91.7 0.2 7.8e-26 91.0 0.2 1.2 1 0 0 1 1 1 1 Subtilase family XPC-binding PF09280.11 KOO30079.1 - 0.0001 22.0 0.5 0.0001 22.0 0.5 2.2 3 0 0 3 3 3 1 XPC-binding domain UBA PF00627.31 KOO30079.1 - 0.0013 18.6 0.3 0.0033 17.3 0.0 1.8 2 0 0 2 2 2 1 UBA/TS-N domain Mo25 PF08569.11 KOO30079.1 - 0.23 10.8 0.0 0.53 9.6 0.0 1.5 2 0 0 2 2 2 0 Mo25-like Zn_Tnp_IS91 PF14319.6 KOO30079.1 - 2.6 8.1 6.2 5.8 7.0 2.5 2.2 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-B_box PF00643.24 KOO30079.1 - 3.8 7.8 8.7 0.23 11.7 2.1 2.3 3 0 0 3 3 3 0 B-box zinc finger Taxilin PF09728.9 KOO30080.1 - 0.0085 15.3 0.6 0.0085 15.3 0.6 3.8 2 1 0 2 2 2 1 Myosin-like coiled-coil protein SKA2 PF16740.5 KOO30080.1 - 0.17 11.7 0.1 0.17 11.7 0.1 3.3 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Vac_Fusion PF02346.16 KOO30080.1 - 0.27 10.9 2.8 1.6 8.4 0.0 3.1 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Jnk-SapK_ap_N PF09744.9 KOO30080.1 - 0.31 11.2 0.1 0.31 11.2 0.1 3.2 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Sec34 PF04136.15 KOO30080.1 - 0.38 10.6 9.3 2.7 7.9 0.1 3.3 3 1 0 3 3 3 0 Sec34-like family DcrB PF08786.11 KOO30080.1 - 0.47 10.6 5.1 0.4 10.8 1.5 2.4 2 0 0 2 2 2 0 DcrB TMF_TATA_bd PF12325.8 KOO30080.1 - 0.53 10.5 16.0 0.083 13.1 2.1 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding MCPVI PF02993.14 KOO30080.1 - 0.79 9.5 4.4 0.7 9.7 2.6 1.8 1 1 0 1 1 1 0 Minor capsid protein VI L27_1 PF09058.10 KOO30080.1 - 0.82 9.7 4.7 5.7 7.0 1.2 3.3 3 0 0 3 3 3 0 L27_1 YabA PF06156.13 KOO30080.1 - 1.1 9.9 11.1 1.1 9.9 0.3 3.5 2 1 2 4 4 4 0 Initiation control protein YabA V_ATPase_I PF01496.19 KOO30080.1 - 1.5 6.6 7.3 9.7 4.0 0.1 2.8 2 1 1 3 3 3 0 V-type ATPase 116kDa subunit family Baculo_PEP_C PF04513.12 KOO30080.1 - 8.8 6.4 8.4 13 5.8 0.8 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pyr_redox_2 PF07992.14 KOO30081.1 - 9.2e-72 241.7 5.3 1.3e-71 241.2 5.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOO30081.1 - 2.2e-40 137.4 2.0 3.6e-40 136.6 0.7 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOO30081.1 - 6.8e-21 74.6 8.9 3.3e-18 66.0 0.3 4.0 5 0 0 5 5 4 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KOO30081.1 - 1.4e-12 47.8 3.3 4.4e-10 39.5 0.4 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 KOO30081.1 - 5.2e-10 39.0 6.5 5.2e-09 35.7 2.9 2.7 2 1 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 KOO30081.1 - 1.2e-09 38.3 2.9 0.00019 21.6 0.6 3.1 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOO30081.1 - 3.2e-09 36.5 4.3 8.2e-06 25.3 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO30081.1 - 2.5e-08 33.5 11.1 1.1e-05 24.7 0.9 3.6 4 0 0 4 4 4 2 FAD binding domain AlaDh_PNT_C PF01262.21 KOO30081.1 - 7.9e-07 28.6 2.7 0.019 14.3 0.1 2.7 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KOO30081.1 - 2.6e-05 23.1 12.0 0.00036 19.4 1.4 3.5 4 0 0 4 4 4 2 HI0933-like protein K_oxygenase PF13434.6 KOO30081.1 - 4.3e-05 22.8 0.7 0.14 11.2 0.1 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 KOO30081.1 - 0.00014 21.2 3.6 0.019 14.2 0.8 2.3 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 KOO30081.1 - 0.00045 19.5 0.2 0.00045 19.5 0.2 2.7 3 1 0 3 3 3 1 Thi4 family Lycopene_cycl PF05834.12 KOO30081.1 - 0.06 12.4 3.0 0.3 10.1 0.0 2.8 2 1 1 3 3 3 0 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 KOO30081.1 - 0.12 11.7 0.3 9.1 5.6 0.1 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 KOO30081.1 - 0.19 12.2 0.3 5.2 7.6 0.1 2.7 2 0 0 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 KOO30081.1 - 0.23 11.3 3.8 0.22 11.4 0.2 2.6 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 KOO30081.1 - 0.42 10.1 12.0 1.5 8.4 0.4 3.5 3 0 0 3 3 3 0 FAD dependent oxidoreductase tRNA-synt_2 PF00152.20 KOO30082.1 - 1.2e-63 215.1 0.0 8.1e-43 146.7 0.0 3.1 2 1 1 3 3 3 3 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOO30082.1 - 9.4e-11 41.5 0.2 1.7e-10 40.7 0.2 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain WHEP-TRS PF00458.20 KOO30082.1 - 3.9e-10 39.7 1.9 7.2e-10 38.9 1.9 1.5 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_2d PF01409.20 KOO30082.1 - 0.054 13.0 0.1 1.8 8.0 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Pro_racemase PF05544.11 KOO30083.1 - 3e-90 302.6 0.0 5.9e-90 301.6 0.0 1.4 1 1 0 1 1 1 1 Proline racemase DAP_epimerase PF01678.19 KOO30083.1 - 0.002 18.3 0.0 0.19 11.9 0.2 2.3 2 0 0 2 2 2 2 Diaminopimelate epimerase TTL PF03133.15 KOO30084.1 - 3.5e-84 282.4 0.0 5e-84 281.9 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO30084.1 - 0.00096 18.5 0.0 0.063 12.5 0.0 2.8 2 1 1 3 3 3 1 YheC/D like ATP-grasp ATP-grasp_3 PF02655.14 KOO30084.1 - 0.035 14.2 0.0 0.29 11.2 0.0 2.3 2 1 1 3 3 3 0 ATP-grasp domain ATPgrasp_ST PF14397.6 KOO30084.1 - 0.07 12.4 0.0 0.73 9.0 0.0 2.0 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Ubiquitin_3 PF14836.6 KOO30085.1 - 0.11 12.5 1.3 2.4 8.2 0.1 2.8 2 2 0 2 2 2 0 Ubiquitin-like domain CBP4 PF07960.11 KOO30085.1 - 0.73 9.7 4.5 0.17 11.8 0.4 2.0 2 1 1 3 3 3 0 CBP4 YscO-like PF16789.5 KOO30085.1 - 5.4 7.0 18.2 5.8 6.9 15.9 2.5 1 1 1 2 2 2 0 YscO-like protein EF-hand_1 PF00036.32 KOO30086.1 - 2.3e-33 111.2 11.3 4.6e-09 35.2 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO30086.1 - 1e-29 102.8 8.4 1.6e-16 60.5 0.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO30086.1 - 7.4e-26 87.8 9.4 2.6e-09 36.2 0.0 4.9 4 2 2 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 KOO30086.1 - 1.8e-25 88.5 10.9 5.7e-12 45.3 0.3 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO30086.1 - 3.5e-20 70.5 9.0 2.1e-06 26.9 0.2 4.7 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.6 KOO30086.1 - 6.5e-14 52.0 0.2 8.2e-08 32.5 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO30086.1 - 2.5e-06 27.4 4.0 0.2 11.7 0.9 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SurA_N_3 PF13624.6 KOO30086.1 - 0.00015 21.6 0.8 0.4 10.4 0.0 2.1 1 1 1 2 2 2 2 SurA N-terminal domain Caleosin PF05042.13 KOO30086.1 - 0.00046 20.1 1.0 3.7 7.4 0.0 3.6 1 1 3 4 4 4 1 Caleosin related protein SurA_N_2 PF13623.6 KOO30086.1 - 0.00092 19.1 0.7 0.93 9.3 0.0 2.3 1 1 1 2 2 2 2 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KOO30086.1 - 0.0016 18.7 0.5 0.81 10.0 0.2 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO30086.1 - 0.0037 17.6 0.6 1.5 9.2 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain SUB1_ProdP9 PF18213.1 KOO30086.1 - 0.013 15.4 1.4 0.03 14.2 0.5 2.0 1 1 1 2 2 2 0 SUB1 protease Prodomain ProdP9 DUF3008 PF11450.8 KOO30086.1 - 0.019 15.1 5.0 0.025 14.8 0.2 3.0 4 0 0 4 4 3 0 Protein of unknwon function (DUF3008) TerB PF05099.13 KOO30086.1 - 0.049 13.6 1.9 4.8 7.1 0.1 2.5 1 1 1 2 2 2 0 Tellurite resistance protein TerB LETM1 PF07766.13 KOO30086.1 - 0.058 12.7 0.6 0.19 11.1 0.5 1.8 1 1 1 2 2 2 0 LETM1-like protein YolD PF08863.10 KOO30086.1 - 0.087 12.9 2.1 4.4 7.4 0.0 2.7 3 1 0 3 3 3 0 YolD-like protein Peptidase_M24 PF00557.24 KOO30086.1 - 0.095 12.4 0.2 1.8 8.2 0.0 2.4 2 1 1 3 3 3 0 Metallopeptidase family M24 DUF3911 PF13050.6 KOO30086.1 - 0.12 12.5 1.5 0.43 10.7 0.6 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3911) Acetyltransf_11 PF13720.6 KOO30086.1 - 0.15 12.5 0.3 1.2 9.6 0.1 2.3 1 1 1 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 PMBR PF09373.10 KOO30086.1 - 0.17 12.1 0.2 23 5.4 0.0 4.2 6 0 0 6 6 6 0 Pseudomurein-binding repeat SapB_1 PF05184.15 KOO30086.1 - 1.2 9.2 6.8 3.3 7.8 0.2 2.6 3 0 0 3 3 2 0 Saposin-like type B, region 1 IQ PF00612.27 KOO30087.1 - 0.00012 21.5 0.1 0.0096 15.6 0.0 2.6 2 0 0 2 2 2 1 IQ calmodulin-binding motif PX PF00787.24 KOO30087.1 - 0.0015 18.5 0.0 0.0023 17.9 0.0 1.2 1 0 0 1 1 1 1 PX domain Mg_trans_NIPA PF05653.14 KOO30088.1 - 5.1e-12 45.5 10.3 8e-12 44.9 10.3 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA TMEM234 PF10639.9 KOO30088.1 - 0.33 11.0 3.9 0.084 12.9 0.5 1.8 2 0 0 2 2 2 0 Putative transmembrane family 234 TMP-TENI PF02581.17 KOO30089.1 - 2.4e-44 150.8 2.7 4.4e-44 150.0 2.7 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 KOO30089.1 - 1.5e-29 103.1 0.7 2.4e-29 102.5 0.1 1.6 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase DUF561 PF04481.12 KOO30089.1 - 0.035 13.3 0.0 0.087 12.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF561) AOX PF01786.17 KOO30089.1 - 0.096 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Alternative oxidase AIRS PF00586.24 KOO30089.1 - 3.2 8.5 6.1 1.2 9.9 1.7 2.5 2 1 1 3 3 3 0 AIR synthase related protein, N-terminal domain DUF1143 PF06608.11 KOO30090.1 - 0.11 12.6 0.4 0.26 11.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1143) Mg_trans_NIPA PF05653.14 KOO30091.1 - 2.2e-05 23.7 3.9 0.00055 19.1 0.2 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 KOO30091.1 - 0.024 14.8 1.3 0.024 14.8 1.3 2.8 3 0 0 3 3 3 0 EamA-like transporter family VDE PF07137.11 KOO30092.1 - 1.1e-92 309.9 1.3 1.3e-92 309.6 1.3 1.1 1 0 0 1 1 1 1 VDE lipocalin domain TylF PF05711.11 KOO30093.1 - 4.1e-22 78.7 0.0 5.4e-22 78.3 0.0 1.3 1 1 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 KOO30093.1 - 1.4e-05 26.1 0.0 1.9e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FAD_binding_3 PF01494.19 KOO30094.1 - 4.7e-19 68.8 0.0 7.8e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 KOO30094.1 - 0.0011 18.1 0.0 0.02 13.9 0.0 2.0 2 0 0 2 2 2 1 Squalene epoxidase Lycopene_cycl PF05834.12 KOO30094.1 - 0.0036 16.4 1.5 0.0066 15.5 0.0 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 KOO30094.1 - 0.068 12.5 0.3 0.2 10.9 0.1 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PseudoU_synth_2 PF00849.22 KOO30095.1 - 9.6e-28 97.3 0.0 1.7e-27 96.5 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 KOO30095.1 - 4e-06 26.4 0.1 3.4e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 S4 domain S4_2 PF13275.6 KOO30095.1 - 0.0041 16.9 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 S4 domain DUF3138 PF11336.8 KOO30095.1 - 7 5.1 6.7 10 4.6 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Methyltransf_16 PF10294.9 KOO30096.1 - 1.5e-09 37.9 0.0 2e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Na_H_Exchanger PF00999.21 KOO30097.1 - 1.5e-43 149.0 18.4 2.2e-43 148.5 18.4 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family UCH PF00443.29 KOO30098.1 - 9.4e-27 94.1 0.0 1.5e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 KOO30098.1 - 1.3e-22 79.3 0.0 2.4e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 Variant UBP zinc finger UBA PF00627.31 KOO30098.1 - 1.7e-16 59.7 2.6 4.9e-09 35.9 0.1 3.4 3 0 0 3 3 3 2 UBA/TS-N domain zf-UBP PF02148.19 KOO30098.1 - 7.6e-08 32.6 0.0 1.4e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein DNA_Packaging_2 PF11123.8 KOO30098.1 - 0.015 15.5 0.6 0.035 14.3 0.0 1.9 2 0 0 2 2 2 0 DNA packaging protein UCH_1 PF13423.6 KOO30098.1 - 0.038 13.6 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Ank_2 PF12796.7 KOO30100.1 - 2.5e-17 63.2 3.2 9.6e-09 35.7 0.3 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO30100.1 - 4.4e-14 52.7 5.2 5.2e-06 26.9 0.3 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO30100.1 - 1.1e-13 50.9 7.0 0.00047 20.5 0.2 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 KOO30100.1 - 8.6e-11 41.1 2.4 0.005 17.2 0.1 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KOO30100.1 - 2.5e-09 37.2 3.4 0.0013 19.0 0.3 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) LSDAT_euk PF18139.1 KOO30101.1 - 8.2e-20 71.3 0.0 1.3e-12 47.7 0.0 3.2 2 1 0 2 2 2 2 SLOG in TRPM LSDAT_prok PF18171.1 KOO30101.1 - 5.5e-12 45.3 0.5 0.00024 20.4 0.1 3.2 2 1 0 2 2 2 2 SLOG in TRPM, prokaryote NUDIX PF00293.28 KOO30101.1 - 2.7e-09 37.1 0.2 5.8e-08 32.8 0.0 2.6 2 0 0 2 2 2 1 NUDIX domain EF-hand_6 PF13405.6 KOO30101.1 - 0.00026 20.7 0.0 0.00084 19.1 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO30101.1 - 0.0033 16.9 0.0 0.0074 15.8 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO30101.1 - 0.0087 16.5 0.0 0.025 15.0 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair Cas3_C PF18395.1 KOO30101.1 - 0.11 13.0 0.0 3.4 8.2 0.0 2.8 2 0 0 2 2 2 0 Cas3 C-terminal domain Ion_trans PF00520.31 KOO30101.1 - 0.6 9.3 3.0 0.94 8.7 3.0 1.2 1 0 0 1 1 1 0 Ion transport protein DUF4473 PF14747.6 KOO30102.1 - 0.0077 16.8 0.1 0.03 14.9 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4473) RNA_pol_N PF01194.17 KOO30103.1 - 1e-30 105.8 1.1 1.5e-30 105.2 1.1 1.3 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 KOO30103.1 - 0.02 15.2 0.2 0.028 14.7 0.2 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) YebG PF07130.12 KOO30103.1 - 0.075 12.9 0.2 8.9 6.2 0.1 2.2 2 0 0 2 2 2 0 YebG protein Cytochrom_B561 PF03188.16 KOO30104.1 - 4.6e-22 78.6 11.2 4.6e-22 78.6 11.2 1.7 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF2407_C PF13373.6 KOO30104.1 - 0.26 11.5 0.2 0.46 10.7 0.2 1.4 1 0 0 1 1 1 0 DUF2407 C-terminal domain DUF4079 PF13301.6 KOO30104.1 - 3.9 7.6 19.5 2.8 8.1 8.1 3.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) DUF3011 PF11218.8 KOO30105.1 - 0.056 13.4 0.2 0.087 12.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3011) PA28_beta PF02252.18 KOO30107.1 - 0.0001 22.0 0.0 0.00025 20.7 0.0 1.6 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit MitMem_reg PF13012.6 KOO30107.1 - 0.033 14.6 0.8 0.12 12.8 0.8 2.0 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function gag_pre-integrs PF13976.6 KOO30108.1 - 0.0015 18.4 1.9 0.002 18.0 0.2 1.9 2 0 0 2 2 2 1 GAG-pre-integrase domain LRR_6 PF13516.6 KOO30111.1 - 3e-17 61.1 4.3 0.002 18.0 0.0 5.7 5 0 0 5 5 5 4 Leucine Rich repeat NACHT PF05729.12 KOO30111.1 - 0.00028 20.9 0.0 0.00071 19.5 0.0 1.7 1 0 0 1 1 1 1 NACHT domain LRR_4 PF12799.7 KOO30111.1 - 0.016 15.6 1.0 0.64 10.5 0.2 3.6 3 1 0 4 4 4 0 Leucine Rich repeats (2 copies) CENP-B_dimeris PF09026.10 KOO30113.1 - 0.023 15.1 14.6 0.03 14.7 14.6 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF3246 PF11596.8 KOO30113.1 - 0.024 14.1 1.6 0.026 14.0 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) FAM176 PF14851.6 KOO30113.1 - 0.051 13.2 8.3 0.062 13.0 8.3 1.2 1 0 0 1 1 1 0 FAM176 family DUF2457 PF10446.9 KOO30113.1 - 0.06 12.5 11.8 0.063 12.4 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 KOO30113.1 - 0.094 12.0 12.9 0.1 11.9 12.9 1.0 1 0 0 1 1 1 0 NOA36 protein GP67 PF17634.2 KOO30113.1 - 0.12 12.8 16.7 0.19 12.2 16.7 1.4 1 0 0 1 1 1 0 Gene product 67 DUF3464 PF11947.8 KOO30113.1 - 0.15 11.8 3.4 0.18 11.5 3.4 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Dicty_REP PF05086.12 KOO30113.1 - 0.16 10.0 13.3 0.17 9.8 13.3 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Trypan_PARP PF05887.11 KOO30113.1 - 0.18 11.8 5.5 0.2 11.6 5.5 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) eIF-3c_N PF05470.12 KOO30113.1 - 0.21 9.8 7.0 0.23 9.7 7.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DNA_pol_phi PF04931.13 KOO30113.1 - 0.26 9.3 12.7 0.25 9.4 12.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 KOO30113.1 - 0.36 10.6 10.4 0.42 10.4 10.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RXT2_N PF08595.11 KOO30113.1 - 0.43 10.6 9.4 0.46 10.5 9.4 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal Rhabdo_ncap PF00945.18 KOO30113.1 - 0.45 9.3 2.8 0.46 9.3 2.8 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein TFB6 PF17110.5 KOO30113.1 - 0.47 10.2 5.8 0.49 10.1 5.8 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Myc_N PF01056.18 KOO30113.1 - 0.47 10.3 7.8 0.49 10.3 7.8 1.1 1 0 0 1 1 1 0 Myc amino-terminal region RIBIOP_C PF04950.12 KOO30113.1 - 0.48 9.8 1.4 0.53 9.7 1.4 1.0 1 0 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Sporozoite_P67 PF05642.11 KOO30113.1 - 0.65 8.0 7.5 0.65 8.0 7.5 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Cwf_Cwc_15 PF04889.12 KOO30113.1 - 1 9.0 15.7 1.2 8.8 15.7 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4637 PF15470.6 KOO30113.1 - 1.3 8.7 8.0 1.5 8.6 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CDC45 PF02724.14 KOO30113.1 - 1.3 7.2 11.8 1.4 7.1 11.8 1.0 1 0 0 1 1 1 0 CDC45-like protein TLP-20 PF06088.11 KOO30113.1 - 1.4 8.8 6.1 1.6 8.6 6.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) GCIP PF13324.6 KOO30113.1 - 1.5 8.4 5.5 1.4 8.5 5.5 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Nop14 PF04147.12 KOO30113.1 - 2.1 6.5 12.9 2.1 6.5 12.9 1.0 1 0 0 1 1 1 0 Nop14-like family SLAIN PF15301.6 KOO30113.1 - 2.3 7.4 6.5 2.6 7.2 6.5 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family Nucleo_P87 PF07267.11 KOO30113.1 - 2.5 6.9 12.6 2.7 6.7 12.6 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4746 PF15928.5 KOO30113.1 - 2.6 7.4 8.0 2.8 7.3 8.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PPP4R2 PF09184.11 KOO30113.1 - 3.5 7.2 14.8 4 6.9 14.8 1.0 1 0 0 1 1 1 0 PPP4R2 SURF2 PF05477.11 KOO30113.1 - 3.8 7.2 8.8 4.2 7.0 8.8 1.0 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) RRN3 PF05327.11 KOO30113.1 - 5.1 5.5 7.7 5 5.6 7.7 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pes-10 PF07149.11 KOO30113.1 - 5.2 6.0 8.2 5 6.1 8.2 1.1 1 0 0 1 1 1 0 Pes-10 TRAP_alpha PF03896.16 KOO30113.1 - 5.7 6.1 8.0 5.9 6.0 8.0 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Cytomega_UL84 PF06284.11 KOO30113.1 - 8.5 4.7 8.2 8.7 4.7 8.2 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein LRR_5 PF13306.6 KOO30114.1 - 9.8e-66 219.5 0.2 7.7e-36 122.9 0.0 2.1 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO30114.1 - 1.3e-13 50.5 0.0 0.033 13.9 0.0 6.0 3 2 4 7 7 7 6 Leucine rich repeat ZF-HD_dimer PF04770.12 KOO30114.1 - 0.31 11.4 1.3 11 6.5 0.0 3.3 3 0 0 3 3 3 0 ZF-HD protein dimerisation region Mitoc_L55 PF09776.9 KOO30115.1 - 0.0049 16.6 0.1 32 4.3 0.0 3.9 1 1 3 4 4 4 3 Mitochondrial ribosomal protein L55 EF-hand_7 PF13499.6 KOO30116.1 - 2.6e-18 66.2 0.0 8.3e-08 32.6 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO30116.1 - 5.1e-17 60.3 0.9 0.00012 21.7 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO30116.1 - 5.9e-16 56.8 0.1 3.6e-05 23.0 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO30116.1 - 4.6e-12 44.9 0.2 0.002 17.5 0.0 4.5 4 0 0 4 4 4 2 EF hand GPS PF01825.21 KOO30116.1 - 4.3e-08 33.6 3.2 1e-07 32.4 3.2 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EF-hand_8 PF13833.6 KOO30116.1 - 0.0097 15.7 0.0 2 8.3 0.0 2.9 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO30116.1 - 0.027 14.8 0.6 11 6.5 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain Ctr PF04145.15 KOO30116.1 - 0.2 12.2 0.9 0.54 10.9 0.2 2.1 2 0 0 2 2 2 0 Ctr copper transporter family DUF4690 PF15756.5 KOO30117.1 - 0.0023 18.5 0.3 0.013 16.1 0.3 2.3 1 0 0 1 1 1 1 Small Novel Rich in Cartilage rve PF00665.26 KOO30118.1 - 2.3e-07 31.0 0.0 5.6e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain SH3_19 PF18597.1 KOO30119.1 - 0.082 12.7 0.1 0.3 11.0 0.1 1.8 2 0 0 2 2 2 0 Myosin X N-terminal SH3 domain Gelsolin PF00626.22 KOO30121.1 - 3.1e-44 148.7 0.0 2.4e-10 40.2 0.0 6.9 7 0 0 7 7 7 6 Gelsolin repeat VHP PF02209.19 KOO30121.1 - 3.6e-14 52.5 4.6 7.3e-14 51.6 4.6 1.5 1 0 0 1 1 1 1 Villin headpiece domain EF-hand_1 PF00036.32 KOO30121.1 - 2e-06 26.9 4.0 0.00054 19.3 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO30121.1 - 3.5e-05 24.2 0.2 0.00011 22.5 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO30121.1 - 7.8e-05 22.3 5.4 0.00077 19.2 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain Ank_3 PF13606.6 KOO30121.1 - 0.00029 21.0 0.2 34 5.5 0.1 5.5 5 0 0 5 5 5 0 Ankyrin repeat EF-hand_5 PF13202.6 KOO30121.1 - 0.00066 19.1 0.0 0.00066 19.1 0.0 2.9 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 KOO30121.1 - 0.0011 18.7 0.1 0.072 12.9 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain pair FliH PF02108.16 KOO30123.1 - 0.11 12.6 3.5 0.28 11.3 3.5 1.7 1 0 0 1 1 1 0 Flagellar assembly protein FliH Pilus_CpaD PF09476.10 KOO30123.1 - 0.15 11.8 5.2 0.36 10.5 4.5 1.9 2 0 0 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) FapA PF03961.13 KOO30123.1 - 2.1 6.9 6.4 3.3 6.2 6.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A YlqD PF11068.8 KOO30123.1 - 6.6 7.1 14.8 6.7 7.1 6.1 2.3 2 0 0 2 2 2 0 YlqD protein Ribosomal_S15 PF00312.22 KOO30125.1 - 1.7e-26 92.2 0.7 2.3e-26 91.8 0.7 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 Csm2_III-A PF03750.13 KOO30125.1 - 0.1 13.4 0.5 1.3 9.9 0.3 2.2 1 1 1 2 2 2 0 Csm2 Type III-A TAT_signal PF10518.9 KOO30126.1 - 0.0046 16.7 0.8 0.0046 16.7 0.8 4.3 4 0 0 4 4 4 1 TAT (twin-arginine translocation) pathway signal sequence Exo_endo_phos PF03372.23 KOO30127.1 - 1.9e-08 34.1 0.4 3.4e-07 30.0 0.4 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ShK PF01549.24 KOO30129.1 - 6.1e-26 90.7 44.8 1.3e-06 28.8 4.0 5.6 5 0 0 5 5 5 5 ShK domain-like 2OG-FeII_Oxy_3 PF13640.6 KOO30129.1 - 4.7e-16 59.4 0.0 8.9e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily BACK PF07707.15 KOO30130.1 - 1.4e-17 63.6 0.2 3e-17 62.6 0.0 1.6 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 KOO30130.1 - 6.1e-06 26.4 0.0 1.9e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain Wtap PF17098.5 KOO30132.1 - 3e-25 89.0 13.6 3e-25 89.0 13.6 1.8 1 1 1 2 2 2 1 WTAP/Mum2p family GAS PF13851.6 KOO30132.1 - 0.0023 17.3 15.7 0.007 15.7 14.4 1.9 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding GldM_N PF12081.8 KOO30132.1 - 0.012 15.7 2.6 0.14 12.2 0.1 2.0 1 1 1 2 2 2 0 GldM N-terminal domain RNA_pol_Rpb1_6 PF04992.14 KOO30132.1 - 0.015 15.1 0.5 0.016 15.1 0.5 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 DUF4618 PF15397.6 KOO30132.1 - 0.02 14.3 10.0 0.024 14.0 10.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) ArsR PF09824.9 KOO30132.1 - 0.05 13.2 0.1 0.068 12.8 0.1 1.3 1 1 0 1 1 1 0 ArsR transcriptional regulator TSC22 PF01166.18 KOO30132.1 - 0.058 13.7 0.6 0.058 13.7 0.6 3.2 2 1 0 3 3 3 0 TSC-22/dip/bun family bZIP_1 PF00170.21 KOO30132.1 - 0.074 13.2 2.1 0.074 13.2 2.1 3.1 2 1 2 4 4 4 0 bZIP transcription factor WEMBL PF05701.11 KOO30132.1 - 0.11 11.2 15.5 0.46 9.1 15.5 1.8 1 1 0 1 1 1 0 Weak chloroplast movement under blue light DUF4201 PF13870.6 KOO30132.1 - 0.14 11.9 13.4 0.44 10.3 7.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Seryl_tRNA_N PF02403.22 KOO30132.1 - 0.33 11.2 12.1 0.45 10.8 11.4 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HIP1_clath_bdg PF16515.5 KOO30132.1 - 0.47 11.1 16.4 13 6.4 13.6 2.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PV-1 PF06637.11 KOO30132.1 - 0.47 9.2 11.9 0.61 8.9 11.9 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) Cep57_MT_bd PF06657.13 KOO30132.1 - 0.62 10.6 11.6 0.15 12.6 2.3 2.5 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 ATG16 PF08614.11 KOO30132.1 - 0.66 10.2 17.8 3.2 7.9 2.8 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Atg14 PF10186.9 KOO30132.1 - 0.85 8.6 9.1 1.3 8.1 9.1 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 KOO30132.1 - 0.97 9.5 4.2 0.79 9.8 2.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) HAP1_N PF04849.13 KOO30132.1 - 1.1 8.4 15.5 3.9 6.6 7.3 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region CENP-K PF11802.8 KOO30132.1 - 1.6 8.3 10.9 2.3 7.7 10.9 1.4 1 1 0 1 1 1 0 Centromere-associated protein K DUF641 PF04859.12 KOO30132.1 - 1.6 9.1 9.6 10 6.5 9.6 2.1 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) TMPIT PF07851.13 KOO30132.1 - 2.6 7.2 6.1 3.4 6.8 6.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 KOO30132.1 - 2.8 6.5 6.4 3.4 6.2 6.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc7 PF08317.11 KOO30132.1 - 3 6.6 15.7 4.6 6.0 15.7 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein FliJ PF02050.16 KOO30132.1 - 3.7 7.8 16.2 3.2 8.0 8.3 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein DUF2968 PF11180.8 KOO30132.1 - 5.1 6.7 16.4 0.49 10.0 9.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF2205 PF10224.9 KOO30132.1 - 5.8 7.0 10.4 3.5 7.7 2.0 2.3 1 1 1 2 2 2 0 Short coiled-coil protein DUF4407 PF14362.6 KOO30132.1 - 6.2 6.1 12.8 1.9 7.8 2.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) YabA PF06156.13 KOO30132.1 - 6.6 7.4 10.1 38 5.0 2.1 2.5 1 1 1 2 2 2 0 Initiation control protein YabA SlyX PF04102.12 KOO30132.1 - 6.6 7.4 14.4 6.6 7.4 5.8 3.5 2 1 1 3 3 3 0 SlyX FliT PF05400.13 KOO30132.1 - 8.5 7.3 11.8 0.99 10.3 7.3 1.9 2 1 0 2 2 1 0 Flagellar protein FliT MRP-S26 PF14943.6 KOO30132.1 - 8.5 6.3 11.5 17 5.3 11.5 1.5 1 1 0 1 1 1 0 Mitochondrial ribosome subunit S26 ZapB PF06005.12 KOO30132.1 - 10 6.7 21.0 75 3.9 0.8 3.2 2 1 0 2 2 2 0 Cell division protein ZapB FA_hydroxylase PF04116.13 KOO30133.1 - 5.1e-17 62.5 5.7 7.3e-17 62.0 5.7 1.2 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily DUF4381 PF14316.6 KOO30133.1 - 0.11 12.8 6.2 0.15 12.3 3.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4381) TTRAP PF14203.6 KOO30133.1 - 0.11 12.5 5.3 5.9 6.9 0.5 4.1 2 1 0 2 2 2 0 Putative tranposon-transfer assisting protein DUF1664 PF07889.12 KOO30133.1 - 0.19 11.8 49.9 0.14 12.2 2.9 7.3 1 1 6 8 8 8 0 Protein of unknown function (DUF1664) DUF2433 PF10360.9 KOO30133.1 - 0.51 10.4 1.9 37 4.4 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2433) DASH_Duo1 PF08651.10 KOO30133.1 - 0.62 9.9 8.0 8 6.3 1.0 4.7 2 1 2 4 4 4 0 DASH complex subunit Duo1 DASH_Dam1 PF08653.10 KOO30133.1 - 1.7 8.5 5.4 6.3 6.7 0.1 4.3 5 0 0 5 5 5 0 DASH complex subunit Dam1 DUF1542 PF07564.11 KOO30133.1 - 3.3 7.9 10.1 0.61 10.2 0.1 3.9 3 1 0 3 3 3 0 Domain of Unknown Function (DUF1542) cNMP_binding PF00027.29 KOO30134.1 - 3.3e-23 81.6 0.1 7.2e-14 51.6 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain HlyIII PF03006.20 KOO30135.1 - 5.7e-49 166.9 18.5 6.7e-49 166.6 18.5 1.0 1 0 0 1 1 1 1 Haemolysin-III related UAA PF08449.11 KOO30136.1 - 1.4e-50 172.2 6.1 1.6e-50 172.0 6.1 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO30136.1 - 5.6e-06 26.6 20.0 0.0033 17.6 8.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family SLC35F PF06027.12 KOO30136.1 - 0.00077 19.1 4.1 0.0011 18.6 4.1 1.1 1 0 0 1 1 1 1 Solute carrier family 35 TPT PF03151.16 KOO30136.1 - 0.0033 16.8 4.0 0.005 16.2 4.0 1.3 1 0 0 1 1 1 1 Triose-phosphate Transporter family CRT-like PF08627.10 KOO30136.1 - 0.059 12.3 5.9 0.046 12.7 0.6 2.3 1 1 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like L6_membrane PF05805.12 KOO30136.1 - 0.21 11.2 5.0 0.042 13.4 1.2 1.8 2 0 0 2 2 2 0 L6 membrane protein TMEM234 PF10639.9 KOO30136.1 - 2.5 8.2 6.6 0.42 10.7 1.0 2.1 2 0 0 2 2 2 0 Putative transmembrane family 234 RabGAP-TBC PF00566.18 KOO30137.1 - 1.4e-17 64.1 0.0 2.2e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Glyco_hydro_31 PF01055.26 KOO30138.1 - 3.3e-82 277.0 0.5 4.2e-82 276.7 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 ShK PF01549.24 KOO30138.1 - 0.00053 20.5 3.6 0.0011 19.4 3.6 1.5 1 0 0 1 1 1 1 ShK domain-like UCH PF00443.29 KOO30139.1 - 2.5e-47 161.5 0.0 3.2e-47 161.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO30139.1 - 3.5e-19 69.5 0.2 1.1e-18 68.0 0.2 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase IQ PF00612.27 KOO30142.1 - 4e-15 54.1 41.7 0.0016 18.1 0.1 7.2 7 0 0 7 7 7 6 IQ calmodulin-binding motif EF-hand_7 PF13499.6 KOO30142.1 - 1.3e-08 35.2 1.8 2.1e-08 34.5 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO30142.1 - 7.1e-08 31.8 0.0 0.0049 16.7 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO30142.1 - 3.3e-07 29.4 0.0 0.011 15.2 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO30142.1 - 7.4e-05 22.1 1.1 0.12 11.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO30142.1 - 0.00082 19.2 0.0 0.076 12.9 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair FKBP_C PF00254.28 KOO30143.1 - 2.4e-20 72.6 0.0 3.5e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 KOO30143.1 - 2.2e-09 38.2 0.0 5.8e-09 36.8 0.0 1.7 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase AAA_34 PF13872.6 KOO30144.1 - 2.1e-110 368.3 0.0 4.9e-110 367.2 0.0 1.6 1 1 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 KOO30144.1 - 1.3e-86 290.7 1.6 1.3e-85 287.4 1.6 2.3 1 1 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.15 KOO30144.1 - 4.5e-06 26.8 0.0 0.00079 19.5 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Phage_int_SAM_4 PF13495.6 KOO30144.1 - 0.083 13.4 0.0 0.23 11.9 0.0 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain RVT_2 PF07727.14 KOO30145.1 - 4.6e-23 82.1 0.0 7.8e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lipase_GDSL_2 PF13472.6 KOO30146.1 - 0.0071 16.8 0.0 0.031 14.7 0.0 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family SHS2_Rpb7-N PF03876.17 KOO30147.1 - 9.5e-13 48.3 0.0 1.7e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 KOO30147.1 - 1.6e-12 47.6 0.0 3.9e-12 46.3 0.0 1.6 1 1 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 KOO30147.1 - 0.00013 22.2 0.0 0.00025 21.3 0.0 1.4 2 0 0 2 2 2 1 RNA polymerase III subunit Rpc25 Ank_2 PF12796.7 KOO30148.1 - 3.1e-21 75.7 0.4 2.4e-11 44.0 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) DnaJ PF00226.31 KOO30148.1 - 7.5e-16 58.0 0.1 1.6e-15 57.0 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Ank_4 PF13637.6 KOO30148.1 - 1e-09 38.7 0.2 0.0035 17.9 0.1 3.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO30148.1 - 7.8e-09 35.6 0.1 3.5e-05 24.0 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO30148.1 - 4e-08 32.9 0.1 0.12 13.0 0.0 4.8 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 KOO30148.1 - 4.3e-05 23.8 1.4 0.63 10.6 0.0 4.3 4 1 1 5 5 5 2 Ankyrin repeat TPR_2 PF07719.17 KOO30148.1 - 6.1e-05 22.8 2.6 0.96 9.7 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat CEP209_CC5 PF16574.5 KOO30148.1 - 0.9 9.7 12.3 0.21 11.8 0.4 2.6 2 0 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 Filamin PF00630.19 KOO30149.1 - 8.9e-39 132.5 0.1 2.8e-10 40.9 0.0 7.2 6 1 1 7 7 7 6 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO30149.1 - 1.4e-10 41.3 1.3 0.013 15.7 0.1 5.1 5 1 0 5 5 5 4 Invasin, domain 3 Phycoerythr_ab PF02972.14 KOO30150.1 - 0.48 10.3 1.9 1.1 9.1 1.9 1.6 1 0 0 1 1 1 0 Phycoerythrin, alpha/beta chain Ham1p_like PF01725.16 KOO30152.1 - 2.2e-46 158.1 0.0 2.9e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 Ham1 family DUF295 PF03478.18 KOO30152.1 - 0.11 12.1 0.0 2.9 7.6 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF295) DUF2475 PF10629.9 KOO30154.1 - 1.5e-05 25.1 4.8 0.055 13.7 0.3 3.6 4 0 0 4 4 4 2 Protein of unknown function (DUF2475) IlvN PF07991.12 KOO30155.1 - 8.7e-57 191.3 0.4 1.8e-56 190.3 0.1 1.7 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 KOO30155.1 - 7.4e-49 165.7 0.4 1.4e-26 93.5 0.0 2.2 2 0 0 2 2 2 2 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.19 KOO30155.1 - 0.0005 19.5 0.0 0.00092 18.6 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 KOO30155.1 - 0.0015 18.2 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA AdoHcyase_NAD PF00670.21 KOO30155.1 - 0.0045 17.1 0.1 0.0095 16.0 0.1 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 KOO30155.1 - 0.047 14.1 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF4205 PF13898.6 KOO30156.1 - 4.1e-57 193.7 0.0 1e-53 182.5 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4205) Chloroa_b-bind PF00504.21 KOO30157.1 - 9.6e-29 101.0 0.0 1.6e-28 100.3 0.0 1.3 1 1 0 1 1 1 1 Chlorophyll A-B binding protein HIG_1_N PF04588.13 KOO30158.1 - 2.1e-18 66.2 2.7 3e-18 65.8 2.7 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Pkinase PF00069.25 KOO30159.1 - 3.4e-13 49.6 0.0 9.6e-12 44.8 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30159.1 - 3.6e-05 23.2 0.0 0.0002 20.8 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KOO30159.1 - 0.004 17.1 0.0 0.004 17.1 0.0 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family MMR_HSR1_Xtn PF16897.5 KOO30160.1 - 1.7e-37 127.7 0.2 3.1e-37 126.8 0.2 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 KOO30160.1 - 7.6e-18 64.3 0.1 2e-17 63.0 0.0 1.8 2 0 0 2 2 2 1 TGS domain MMR_HSR1 PF01926.23 KOO30160.1 - 1.2e-17 64.0 0.0 2e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOO30160.1 - 8.1e-07 28.7 0.0 7.1e-06 25.6 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOO30160.1 - 0.005 16.9 0.0 0.32 11.1 0.0 2.3 1 1 1 2 2 2 1 Dynamin family MeaB PF03308.16 KOO30160.1 - 0.024 13.6 0.0 0.047 12.7 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FA_desaturase PF00487.24 KOO30161.1 - 1.3e-13 51.4 23.7 1.3e-13 51.4 23.7 2.7 2 1 1 3 3 3 2 Fatty acid desaturase Halogen_Hydrol PF10112.9 KOO30161.1 - 0.24 11.4 0.0 0.44 10.5 0.0 1.3 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein SSF PF00474.17 KOO30162.1 - 1.1e-14 54.2 30.5 1.1e-14 54.2 30.5 2.0 2 1 0 2 2 2 1 Sodium:solute symporter family SabA_adhesion PF18304.1 KOO30162.1 - 0.045 13.0 0.3 0.071 12.3 0.3 1.2 1 0 0 1 1 1 0 SabA N-terminal extracellular adhesion domain Creatinase_N_2 PF16189.5 KOO30163.1 - 1.4e-38 132.5 0.0 2.4e-37 128.5 0.0 2.2 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 KOO30163.1 - 1.4e-33 116.4 0.0 2.4e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 KOO30163.1 - 6.7e-16 59.2 0.1 4.6e-13 50.0 0.0 2.8 2 1 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 KOO30163.1 - 0.0005 20.1 0.0 0.0017 18.4 0.0 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 EccE PF11203.8 KOO30163.1 - 0.031 14.6 0.2 0.13 12.6 0.0 2.1 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE DUF2007 PF09413.10 KOO30163.1 - 0.081 13.1 0.0 2.2 8.5 0.0 3.0 3 0 0 3 3 3 0 Putative prokaryotic signal transducing protein DUF1803 PF08820.10 KOO30164.1 - 0.063 13.3 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1803) Peptidase_C2 PF00648.21 KOO30165.1 - 1.8e-31 109.3 0.4 2.9e-31 108.6 0.4 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease WWE PF02825.20 KOO30165.1 - 1.4e-23 83.2 0.3 5.6e-11 42.9 0.0 2.7 2 0 0 2 2 2 2 WWE domain FAM199X PF15814.5 KOO30166.1 - 4.5 6.2 8.2 10 5.1 8.2 1.6 1 0 0 1 1 1 0 Protein family FAM199X DSPc PF00782.20 KOO30167.1 - 9.9e-26 90.1 0.0 1.8e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOO30167.1 - 0.0081 15.7 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pkinase_Tyr PF07714.17 KOO30168.1 - 1.8e-08 34.0 0.0 2.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO30168.1 - 3.2e-06 26.7 0.0 5.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PAP_fibrillin PF04755.12 KOO30170.1 - 7.7e-18 65.1 0.0 5.1e-16 59.2 0.0 2.2 1 1 0 1 1 1 1 PAP_fibrillin PP2C PF00481.21 KOO30171.1 - 3.4e-36 125.2 0.0 4.2e-36 124.9 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO30171.1 - 0.0054 16.4 0.1 0.0068 16.1 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C RVT_2 PF07727.14 KOO30172.1 - 4.4e-22 78.9 0.0 6.7e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KOO30172.1 - 1.9e-06 28.1 0.0 4.2e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Macro PF01661.21 KOO30173.1 - 1.3e-21 76.8 0.0 1.7e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Macro domain PP2C PF00481.21 KOO30174.1 - 8.1e-46 156.7 0.1 1.7e-45 155.7 0.0 1.6 2 0 0 2 2 2 1 Protein phosphatase 2C Peptidase_M35 PF02102.15 KOO30174.1 - 0.018 14.0 0.1 0.018 14.0 0.1 1.7 2 0 0 2 2 2 0 Deuterolysin metalloprotease (M35) family DUF4298 PF14131.6 KOO30174.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) DUF5356 PF17309.2 KOO30174.1 - 1.5 8.8 10.0 9.6 6.2 3.8 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5356) Filamin PF00630.19 KOO30175.1 - 8.1e-60 200.1 0.0 1.7e-14 54.5 0.0 6.5 6 0 0 6 6 6 6 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO30175.1 - 2.8e-23 82.0 0.0 5.8e-07 29.7 0.0 4.6 4 0 0 4 4 4 4 Invasin, domain 3 CAP_GLY PF01302.25 KOO30175.1 - 6e-15 55.0 1.6 6e-15 55.0 1.6 1.8 2 0 0 2 2 2 1 CAP-Gly domain YtkA PF13115.6 KOO30175.1 - 0.0014 19.2 0.1 10 6.8 0.0 5.0 5 0 0 5 5 5 1 YtkA-like Big_1 PF02369.16 KOO30175.1 - 0.0018 18.2 0.1 0.37 10.8 0.0 4.3 4 1 1 5 5 5 1 Bacterial Ig-like domain (group 1) MG2 PF01835.19 KOO30175.1 - 0.027 14.9 0.1 0.99 9.9 0.0 3.1 2 0 0 2 2 2 0 MG2 domain Cadherin_5 PF17892.1 KOO30175.1 - 0.031 14.2 0.0 15 5.6 0.0 3.4 3 0 0 3 3 3 0 Cadherin-like domain Big_9 PF17963.1 KOO30175.1 - 0.44 11.3 2.5 31 5.4 0.0 3.9 4 0 0 4 4 4 0 Bacterial Ig domain DUF4239 PF14023.6 KOO30176.1 - 6.3e-30 104.5 3.5 1e-29 103.8 3.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4239) Med20 PF08612.11 KOO30177.1 - 1.9e-11 43.8 0.0 2.5e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex HSP70 PF00012.20 KOO30178.1 - 3.7e-249 827.9 4.1 4.3e-249 827.7 4.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOO30178.1 - 6e-16 58.2 0.4 2.9e-14 52.7 0.2 2.1 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 KOO30178.1 - 0.001 18.8 0.1 0.011 15.4 0.0 2.7 3 1 1 4 4 4 1 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.11 KOO30178.1 - 0.011 15.1 4.3 0.019 14.3 4.3 1.4 1 0 0 1 1 1 0 Radial spoke protein 3 FtsA PF14450.6 KOO30178.1 - 0.087 13.3 1.0 3.7 8.0 0.1 3.3 2 1 0 2 2 2 0 Cell division protein FtsA Hydantoinase_A PF01968.18 KOO30178.1 - 0.098 11.9 1.1 0.53 9.5 0.1 2.4 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase CDP-OH_P_transf PF01066.21 KOO30179.1 - 2.8e-10 40.8 2.0 2.8e-10 40.8 2.0 2.4 2 1 0 2 2 2 2 CDP-alcohol phosphatidyltransferase Pkinase PF00069.25 KOO30180.1 - 1.6e-41 142.4 0.0 3.2e-41 141.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30180.1 - 1.2e-19 70.7 0.0 2.1e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO30180.1 - 0.0012 18.2 0.0 0.0029 17.0 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO30180.1 - 0.029 13.7 0.0 0.69 9.2 0.0 2.5 2 1 0 2 2 2 0 Kinase-like APH PF01636.23 KOO30180.1 - 2.7 7.8 11.5 0.53 10.2 0.1 3.4 2 2 2 4 4 4 0 Phosphotransferase enzyme family OmpA PF00691.20 KOO30181.1 - 6.4e-28 97.0 1.8 1.2e-16 60.8 0.0 3.1 3 0 0 3 3 3 2 OmpA family AP_endonuc_2 PF01261.24 KOO30181.1 - 0.064 12.7 2.3 0.078 12.4 0.1 2.2 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel Pkinase PF00069.25 KOO30184.1 - 7.4e-35 120.6 0.0 1e-34 120.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30184.1 - 2e-20 73.2 0.0 2.8e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO30184.1 - 0.018 14.4 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Aminotran_1_2 PF00155.21 KOO30185.1 - 1.5e-41 142.8 0.0 1.8e-41 142.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KOO30185.1 - 6.3e-05 22.5 0.0 8.4e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Neur_chan_memb PF02932.16 KOO30187.1 - 1.2e-05 25.5 0.1 2e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Helicase_C PF00271.31 KOO30190.1 - 1.5e-11 44.7 0.4 3.5e-11 43.4 0.2 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO30190.1 - 9.1e-08 32.1 0.1 1.8e-07 31.1 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AP2 PF00847.20 KOO30190.1 - 0.00057 20.1 8.1 0.072 13.3 0.1 3.5 4 0 0 4 4 4 2 AP2 domain CedA PF10729.9 KOO30190.1 - 0.0008 19.2 0.0 1 9.2 0.0 3.1 2 0 0 2 2 2 2 Cell division activator CedA ResIII PF04851.15 KOO30190.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Patched PF02460.18 KOO30192.1 - 6.5e-09 34.5 20.2 0.00073 17.8 0.0 2.5 2 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 KOO30192.1 - 0.00035 20.4 23.2 0.0013 18.6 3.3 2.6 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation DUF3899 PF13038.6 KOO30192.1 - 0.032 14.7 0.3 0.73 10.4 0.1 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DUF4804 PF16062.5 KOO30193.1 - 6e-67 226.4 0.0 6.9e-67 226.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4804) Dimer_Tnp_hAT PF05699.14 KOO30194.1 - 3.7e-17 61.9 0.3 1.6e-16 59.8 0.0 2.2 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region HTH_AsnC-type PF13404.6 KOO30196.1 - 0.041 13.7 0.0 19 5.2 0.0 3.1 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain FKBP_N PF01346.18 KOO30197.1 - 4.1e-08 34.1 0.1 1.4e-07 32.3 0.0 1.9 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Tudor-knot PF11717.8 KOO30197.1 - 5.5e-05 23.0 0.1 0.0001 22.1 0.1 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF445 PF04286.12 KOO30197.1 - 0.17 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) EF-hand_6 PF13405.6 KOO30198.1 - 5.1e-20 69.6 2.4 1.8e-05 24.3 0.3 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO30198.1 - 2.9e-19 67.1 7.2 1.1e-05 24.6 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO30198.1 - 5.8e-16 57.2 8.3 0.0012 18.2 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO30198.1 - 2.7e-14 53.3 0.1 9.9e-07 29.1 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO30198.1 - 5.7e-07 29.3 9.5 0.012 15.4 0.1 4.1 2 2 2 4 4 4 2 EF-hand domain pair LRR_4 PF12799.7 KOO30198.1 - 3.2e-05 24.2 0.5 0.25 11.8 0.0 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO30198.1 - 0.0049 16.6 0.5 0.27 11.0 0.2 2.6 2 0 0 2 2 2 1 Leucine rich repeat Glutaredoxin2_C PF04399.13 KOO30198.1 - 0.022 14.6 1.1 1 9.2 0.1 2.8 3 0 0 3 3 3 0 Glutaredoxin 2, C terminal domain VIT1 PF01988.19 KOO30199.1 - 2.4e-52 177.9 3.6 2.8e-52 177.7 3.6 1.0 1 0 0 1 1 1 1 VIT family GST_N PF02798.20 KOO30201.1 - 7.5e-09 35.8 0.0 1.2e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOO30201.1 - 1.8e-08 34.5 0.0 2.8e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOO30201.1 - 0.082 13.3 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain TPR_16 PF13432.6 KOO30202.1 - 3.3e-07 30.9 25.5 3.4e-05 24.4 0.2 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO30202.1 - 0.0011 18.6 9.0 0.081 12.6 0.4 4.1 4 0 0 4 4 4 1 TPR repeat TPR_2 PF07719.17 KOO30202.1 - 0.0035 17.3 20.6 0.36 11.1 1.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO30202.1 - 0.0079 16.5 2.3 8.6 7.0 0.0 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30202.1 - 0.016 16.0 22.4 0.022 15.6 0.2 5.0 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO30202.1 - 0.16 11.9 15.3 2.3 8.2 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO30202.1 - 0.18 12.3 0.2 0.18 12.3 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO30202.1 - 0.6 10.4 16.6 3.2 8.1 0.9 3.4 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO30202.1 - 0.72 10.0 11.7 0.13 12.4 3.4 2.8 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30202.1 - 9.8 6.7 10.5 16 6.0 0.0 4.5 6 1 0 6 6 6 0 Tetratricopeptide repeat Glyco_transf_34 PF05637.12 KOO30207.1 - 0.0003 20.6 0.0 0.76 9.5 0.0 2.2 2 0 0 2 2 2 2 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 KOO30207.1 - 0.012 15.6 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase CreA PF05981.12 KOO30208.1 - 5e-31 107.4 0.1 6.3e-31 107.1 0.1 1.1 1 0 0 1 1 1 1 CreA protein Sema PF01403.19 KOO30208.1 - 0.0029 16.5 0.0 0.0035 16.2 0.0 1.1 1 0 0 1 1 1 1 Sema domain Peptidase_S10 PF00450.22 KOO30209.1 - 5.1e-77 260.0 0.3 6.4e-77 259.7 0.3 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Cyclin_N PF00134.23 KOO30210.1 - 1.8e-07 30.9 0.2 3.1e-07 30.2 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 KOO30210.1 - 2.4e-06 27.9 0.1 2.5e-05 24.6 0.0 2.3 2 1 0 2 2 2 1 Cyclin C-terminal domain Spy1 PF11357.8 KOO30210.1 - 0.003 17.9 0.0 0.0054 17.0 0.0 1.3 1 0 0 1 1 1 1 Cell cycle regulatory protein FMO-like PF00743.19 KOO30211.1 - 4.9e-44 150.6 1.0 8.6e-16 57.4 0.0 5.0 4 1 0 4 4 4 4 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KOO30211.1 - 2e-17 63.4 0.2 1.8e-07 30.8 0.0 3.1 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOO30211.1 - 3.1e-13 49.6 1.3 1.9e-09 37.2 0.8 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOO30211.1 - 4.4e-11 42.5 0.9 1.5e-05 24.3 0.0 4.1 3 1 1 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KOO30211.1 - 5.2e-10 39.4 1.7 3.5e-09 36.8 0.1 3.0 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KOO30211.1 - 1.2e-06 28.1 0.2 3.4e-05 23.3 0.0 2.6 2 1 1 3 3 3 1 Flavin containing amine oxidoreductase DAO PF01266.24 KOO30211.1 - 4.5e-06 26.5 1.8 3.2e-05 23.7 0.1 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOO30211.1 - 7.9e-06 26.4 1.3 0.00024 21.6 0.4 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO30211.1 - 1.4e-05 24.4 0.8 3.3e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 KOO30211.1 - 2.8e-05 23.6 0.5 0.00012 21.4 0.3 1.9 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 KOO30211.1 - 3.2e-05 23.3 2.8 0.00042 19.6 0.9 2.4 3 0 0 3 3 2 1 Thi4 family FAD_oxidored PF12831.7 KOO30211.1 - 6e-05 22.6 1.1 9.7e-05 21.9 1.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 KOO30211.1 - 8.6e-05 22.9 0.0 0.16 12.5 0.0 2.5 2 0 0 2 2 2 2 Putative NAD(P)-binding Shikimate_DH PF01488.20 KOO30211.1 - 0.00014 21.9 0.1 0.065 13.3 0.1 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 KOO30211.1 - 0.00042 19.1 2.2 0.00044 19.1 0.3 1.9 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 KOO30211.1 - 0.0015 18.6 0.9 0.6 10.1 0.1 4.1 4 1 0 4 4 3 1 FAD-NAD(P)-binding GIDA PF01134.22 KOO30211.1 - 0.0078 15.3 4.5 0.16 11.0 0.8 2.8 3 0 0 3 3 3 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 KOO30211.1 - 0.012 14.6 1.2 0.92 8.5 0.2 2.6 2 0 0 2 2 2 0 Lycopene cyclase protein TrkA_N PF02254.18 KOO30211.1 - 0.014 15.7 1.1 0.44 10.8 0.2 2.5 2 0 0 2 2 2 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 KOO30211.1 - 0.021 14.2 0.1 5.1 6.4 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KOO30211.1 - 0.036 13.4 2.0 0.056 12.7 0.3 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 KOO30211.1 - 0.039 13.5 0.3 0.62 9.6 0.1 2.6 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DUF1998 PF09369.10 KOO30211.1 - 0.099 13.4 0.4 13 6.6 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1998) ThiF PF00899.21 KOO30211.1 - 0.1 11.9 0.1 5.6 6.2 0.1 2.3 2 0 0 2 2 2 0 ThiF family Trp_halogenase PF04820.14 KOO30211.1 - 0.11 11.4 1.2 0.4 9.5 0.8 2.0 2 0 0 2 2 2 0 Tryptophan halogenase ApbA PF02558.16 KOO30211.1 - 0.11 12.1 0.2 0.23 11.1 0.2 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Glu_dehyd_C PF16912.5 KOO30211.1 - 0.13 11.7 0.0 0.51 9.8 0.0 1.9 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus Skp1_POZ PF03931.15 KOO30212.1 - 1e-10 41.6 0.0 1.5e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.31 KOO30212.1 - 0.00019 21.6 0.0 0.00026 21.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain MCM_lid PF17855.1 KOO30212.1 - 0.013 15.9 0.1 2 8.9 0.0 2.2 2 0 0 2 2 2 0 MCM AAA-lid domain Gly_transf_sug PF04488.15 KOO30213.1 - 8.8e-07 29.5 0.0 1.9e-06 28.4 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 KOO30213.1 - 0.00022 20.7 0.1 0.47 9.7 0.0 2.1 2 0 0 2 2 2 2 TcdA/TcdB catalytic glycosyltransferase domain CAP_GLY PF01302.25 KOO30216.1 - 2.1e-15 56.5 0.2 3.4e-15 55.8 0.2 1.3 1 0 0 1 1 1 1 CAP-Gly domain Arm PF00514.23 KOO30217.1 - 0.0087 16.1 0.0 0.017 15.2 0.0 1.6 1 0 0 1 1 1 1 Armadillo/beta-catenin-like repeat FlgH PF02107.16 KOO30218.1 - 8 6.0 13.9 0.49 10.0 2.9 2.5 2 1 0 2 2 2 0 Flagellar L-ring protein Arm PF00514.23 KOO30219.1 - 1.4e-39 132.9 57.1 3.8e-05 23.6 0.1 22.7 25 0 0 25 25 25 9 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO30219.1 - 1e-08 35.1 3.6 0.099 12.7 0.1 8.0 7 2 3 10 10 10 3 Spinocerebellar ataxia type 10 protein domain RICTOR_N PF14664.6 KOO30219.1 - 0.00053 19.1 0.7 1.8 7.4 0.0 4.6 3 3 2 5 5 5 1 Rapamycin-insensitive companion of mTOR, N-term Cnd1 PF12717.7 KOO30219.1 - 0.0021 18.1 1.9 8.7 6.4 0.0 5.0 6 0 0 6 6 6 1 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 KOO30219.1 - 0.0031 17.6 0.1 0.098 12.8 0.0 3.4 3 1 1 4 4 4 1 V-ATPase subunit H DUF5578 PF17741.1 KOO30219.1 - 0.038 13.4 15.0 1.3 8.3 0.1 6.9 6 3 2 8 8 8 0 Family of unknown function (DUF5578) RYDR_ITPR PF01365.21 KOO30219.1 - 0.16 11.4 0.3 0.69 9.3 0.0 2.2 3 0 0 3 3 3 0 RIH domain HEAT_2 PF13646.6 KOO30219.1 - 2.4 8.6 58.7 3.5 8.1 0.8 12.1 10 3 3 13 13 13 0 HEAT repeats RNA_pol_Rpb1_R PF05001.13 KOO30219.1 - 3.5 8.2 9.5 24 5.5 6.5 2.7 2 0 0 2 2 2 0 RNA polymerase Rpb1 C-terminal repeat IQ PF00612.27 KOO30220.1 - 3.8e-08 32.4 30.2 0.24 11.3 0.1 8.4 9 0 0 9 9 9 6 IQ calmodulin-binding motif Arm PF00514.23 KOO30221.1 - 3.1e-11 42.9 22.3 0.053 13.6 0.0 10.1 9 2 2 11 11 11 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO30221.1 - 0.76 10.3 12.9 0.64 10.6 0.4 5.0 5 0 0 5 5 5 0 HEAT-like repeat Arm PF00514.23 KOO30222.1 - 9e-18 63.7 4.5 0.00042 20.3 0.0 4.4 4 1 0 4 4 4 4 Armadillo/beta-catenin-like repeat RasGEF_N_2 PF14663.6 KOO30222.1 - 0.0043 17.4 0.6 0.38 11.2 0.1 2.4 2 1 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_2 PF13646.6 KOO30222.1 - 0.01 16.2 8.3 0.13 12.7 1.6 2.4 1 1 1 2 2 2 0 HEAT repeats WAPL PF07814.13 KOO30222.1 - 0.016 14.0 0.2 0.091 11.5 0.1 1.9 1 1 1 2 2 2 0 Wings apart-like protein regulation of heterochromatin V-ATPase_H_N PF03224.14 KOO30222.1 - 0.026 13.8 0.0 0.056 12.7 0.0 1.5 1 1 0 1 1 1 0 V-ATPase subunit H CSN5_C PF18323.1 KOO30222.1 - 0.065 14.2 0.8 0.24 12.4 0.8 2.1 1 1 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain RICTOR_N PF14664.6 KOO30222.1 - 0.096 11.6 0.1 2.1 7.3 0.0 2.1 1 1 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term DUF1702 PF08012.11 KOO30222.1 - 0.1 11.4 1.4 0.18 10.6 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1702) HEAT_EZ PF13513.6 KOO30222.1 - 0.53 10.8 5.9 5.6 7.6 0.2 3.4 2 1 2 4 4 4 0 HEAT-like repeat LRR_6 PF13516.6 KOO30223.1 - 3.3e-09 36.1 0.1 3.9e-05 23.4 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 KOO30223.1 - 0.0058 17.0 0.0 4.2 8.3 0.0 3.1 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_4 PF12799.7 KOO30223.1 - 0.0083 16.5 0.0 0.088 13.3 0.0 2.3 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) LEDGF PF11467.8 KOO30223.1 - 0.062 12.9 0.0 0.079 12.6 0.0 1.1 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) DUF1336 PF07059.12 KOO30224.1 - 5.2e-43 147.7 0.0 6.3e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) DUF572 PF04502.13 KOO30225.1 - 1.7e-62 212.0 7.3 1.9e-62 211.8 7.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) zf-FCS PF06467.14 KOO30225.1 - 0.055 13.4 0.5 4.5 7.3 0.1 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif RNA_pol_N PF01194.17 KOO30225.1 - 1.7 9.0 0.1 1.7 9.0 0.1 2.8 3 1 0 3 3 3 0 RNA polymerases N / 8 kDa subunit zf-C3HC4_4 PF15227.6 KOO30227.1 - 3.9e-08 33.3 11.9 6.5e-08 32.6 11.9 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 KOO30227.1 - 3.3e-06 26.8 8.8 6e-06 26.0 8.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO30227.1 - 3.4e-06 26.8 11.4 5.6e-06 26.1 11.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rad60-SLD PF11976.8 KOO30227.1 - 6.5e-06 25.9 0.0 1.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-RING_UBOX PF13445.6 KOO30227.1 - 1.5e-05 24.9 14.3 3.6e-05 23.7 14.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOO30227.1 - 7.4e-05 22.6 12.4 0.00014 21.8 12.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOO30227.1 - 0.00012 21.8 13.4 0.00026 20.8 13.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO30227.1 - 0.00017 21.9 12.5 0.0003 21.0 12.5 1.4 1 0 0 1 1 1 1 Ring finger domain U-box PF04564.15 KOO30227.1 - 0.0035 17.5 0.0 0.0099 16.0 0.0 1.7 2 0 0 2 2 2 1 U-box domain Prok-RING_4 PF14447.6 KOO30227.1 - 0.0053 16.6 11.5 0.013 15.3 11.5 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KOO30227.1 - 0.0073 16.1 2.1 0.017 14.9 2.1 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.14 KOO30227.1 - 0.023 14.5 0.1 0.063 13.1 0.1 1.8 1 0 0 1 1 1 0 Rad50 zinc hook motif ubiquitin PF00240.23 KOO30227.1 - 0.094 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family zf-rbx1 PF12678.7 KOO30227.1 - 0.9 9.9 6.4 1.8 8.9 6.4 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Filament PF00038.21 KOO30228.1 - 0.0025 17.5 6.1 0.0025 17.5 6.1 5.6 5 2 1 6 6 6 1 Intermediate filament protein GRP PF07172.11 KOO30228.1 - 0.14 12.9 30.0 0.56 10.9 6.4 2.8 2 0 0 2 2 2 0 Glycine rich protein family Ala_racemase_N PF01168.20 KOO30230.1 - 4.9e-20 72.1 0.0 6e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Lant_dehydr_N PF04738.13 KOO30230.1 - 0.11 10.6 0.1 0.23 9.5 0.0 1.5 1 1 0 2 2 2 0 Lantibiotic dehydratase, N terminus Mg_trans_NIPA PF05653.14 KOO30231.1 - 2.7e-17 62.8 11.9 7.2e-10 38.4 0.8 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 KOO30231.1 - 0.0016 18.6 22.1 0.037 14.2 4.1 3.4 3 1 0 3 3 3 2 EamA-like transporter family Glyco_transf_22 PF03901.17 KOO30232.1 - 2.5e-24 86.3 0.5 3.5e-24 85.8 0.5 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family SET PF00856.28 KOO30232.1 - 0.00026 21.4 0.0 0.00049 20.5 0.0 1.5 2 0 0 2 2 2 1 SET domain Amino_oxidase PF01593.24 KOO30234.1 - 0.0052 16.1 0.1 0.007 15.7 0.1 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase F5_F8_type_C PF00754.25 KOO30236.1 - 9.1e-06 25.8 0.0 1.2e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain Glyco_transf_22 PF03901.17 KOO30239.1 - 4.3e-53 181.0 3.4 5.1e-53 180.8 3.4 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF563 PF04577.14 KOO30240.1 - 3.5e-06 27.3 0.0 5.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) PPR_2 PF13041.6 KOO30241.1 - 9.7e-61 201.8 0.1 6.3e-09 35.9 0.0 11.1 2 2 10 12 12 12 10 PPR repeat family PPR_3 PF13812.6 KOO30241.1 - 1.4e-46 156.4 0.0 1.4e-10 41.0 0.0 8.1 6 3 2 8 8 8 6 Pentatricopeptide repeat domain PPR PF01535.20 KOO30241.1 - 5.1e-45 148.6 7.5 0.00024 21.1 0.0 13.3 13 0 0 13 13 13 9 PPR repeat PPR_1 PF12854.7 KOO30241.1 - 5.4e-32 109.2 0.0 0.00011 21.9 0.0 9.7 11 0 0 11 11 11 7 PPR repeat PPR_long PF17177.4 KOO30241.1 - 3.6e-30 104.9 0.1 3.5e-15 56.0 0.0 5.1 1 1 3 5 5 5 5 Pentacotripeptide-repeat region of PRORP SAP PF02037.27 KOO30241.1 - 1.7e-08 34.0 0.4 4.5e-08 32.6 0.4 1.8 1 0 0 1 1 1 1 SAP domain LETM1 PF07766.13 KOO30241.1 - 0.0071 15.7 0.2 0.011 15.0 0.2 1.2 1 0 0 1 1 1 1 LETM1-like protein NETI PF14044.6 KOO30241.1 - 0.016 14.9 0.0 8.4 6.2 0.0 3.5 3 0 0 3 3 3 0 NETI protein ECSIT PF06239.11 KOO30241.1 - 0.027 13.6 0.4 20 4.2 0.0 4.2 3 2 2 5 5 5 0 Evolutionarily conserved signalling intermediate in Toll pathway DUF3368 PF11848.8 KOO30241.1 - 0.047 13.5 0.0 1.1e+02 2.7 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3368) Radical_SAM PF04055.21 KOO30241.1 - 0.15 12.4 0.0 1.3 9.3 0.0 2.4 2 0 0 2 2 2 0 Radical SAM superfamily Aldedh PF00171.22 KOO30242.1 - 1.3e-147 492.1 0.1 1.6e-147 491.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldo_ket_red PF00248.21 KOO30243.1 - 1.9e-42 145.5 0.0 2.6e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family SRCR PF00530.18 KOO30243.1 - 8.7e-16 58.3 0.3 8.7e-16 58.3 0.3 2.2 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KOO30243.1 - 0.091 13.3 0.0 0.54 10.8 0.0 2.3 2 0 0 2 2 2 0 Hepsin, SRCR domain DNA_pol_phi PF04931.13 KOO30243.1 - 9.5 4.2 12.3 14 3.7 12.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi DnaJ_CXXCXGXG PF00684.19 KOO30245.1 - 0.00024 21.4 5.4 0.00042 20.6 5.4 1.4 1 0 0 1 1 1 1 DnaJ central domain PhyH PF05721.13 KOO30246.1 - 0.00076 19.8 0.0 0.001 19.4 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) NYN_YacP PF05991.11 KOO30247.1 - 1.1e-28 100.3 0.1 1.7e-28 99.6 0.1 1.4 1 0 0 1 1 1 1 YacP-like NYN domain DEAD_assoc PF08494.11 KOO30247.1 - 0.051 13.4 1.8 0.14 11.9 1.8 1.7 1 1 0 1 1 1 0 DEAD/H associated DUF5616 PF18481.1 KOO30247.1 - 0.055 13.8 0.2 3.6 7.9 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF5616) HTH_13 PF11972.8 KOO30247.1 - 0.079 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain RNA_pol_Rpb4 PF03874.16 KOO30248.1 - 1.4e-15 57.7 0.2 1.8e-15 57.3 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 PH PF00169.29 KOO30249.1 - 3.4e-08 33.9 0.0 6.1e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 PH domain Drf_GBD PF06371.13 KOO30249.1 - 7.2e-07 28.9 0.0 1.9e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 KOO30249.1 - 4.6e-05 23.1 0.0 7.9e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Diaphanous FH3 Domain PH_4 PF15404.6 KOO30249.1 - 0.085 12.6 0.0 8.9 6.1 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain Pox_A_type_inc PF04508.12 KOO30249.1 - 0.098 12.5 1.0 0.23 11.4 1.0 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat LRR_6 PF13516.6 KOO30252.1 - 1e-19 68.8 2.6 0.0019 18.1 0.1 5.0 4 0 0 4 4 4 4 Leucine Rich repeat SpoU_sub_bind PF08032.12 KOO30252.1 - 0.011 16.0 0.8 1.8 8.9 0.1 2.9 2 1 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding LRR_4 PF12799.7 KOO30252.1 - 0.19 12.2 2.8 1.8 9.1 0.3 3.1 1 1 3 4 4 4 0 Leucine Rich repeats (2 copies) Arm-DNA-bind_1 PF09003.10 KOO30252.1 - 6.8 6.9 17.7 23 5.2 0.2 5.1 3 1 3 6 6 6 0 Bacteriophage lambda integrase, Arm DNA-binding domain HeH PF12949.7 KOO30253.1 - 0.00027 20.6 0.0 0.00079 19.1 0.0 1.8 2 0 0 2 2 2 1 HeH/LEM domain EF-hand_7 PF13499.6 KOO30253.1 - 0.078 13.4 0.0 0.19 12.2 0.0 1.6 2 0 0 2 2 2 0 EF-hand domain pair Rho_N PF07498.12 KOO30253.1 - 0.094 12.7 0.9 0.28 11.1 0.4 2.1 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain EF-hand_6 PF13405.6 KOO30253.1 - 0.14 12.1 0.0 0.43 10.6 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain Methyltransf_16 PF10294.9 KOO30254.1 - 0.072 12.8 0.0 0.075 12.8 0.0 1.0 1 0 0 1 1 1 0 Lysine methyltransferase NTP_transf_2 PF01909.23 KOO30255.1 - 3.4e-10 40.1 0.0 4.3e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 KOO30255.1 - 0.00076 19.5 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Tubulin PF00091.25 KOO30256.1 - 3.7e-36 125.2 0.0 4.1e-36 125.0 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Cons_hypoth698 PF03601.14 KOO30257.1 - 6.3e-62 209.2 16.6 8.5e-62 208.8 16.6 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 698 DUF3487 PF11990.8 KOO30257.1 - 9 6.2 7.1 0.76 9.7 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) OCD_Mu_crystall PF02423.15 KOO30260.1 - 5.2e-47 160.3 0.1 6.8e-47 159.9 0.1 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 KOO30260.1 - 0.00031 20.8 0.0 0.00046 20.3 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Filamin PF00630.19 KOO30261.1 - 7.7e-05 23.5 0.0 1.1 10.2 0.0 3.5 3 1 0 3 3 3 3 Filamin/ABP280 repeat zf-RING_2 PF13639.6 KOO30262.1 - 2.2e-11 43.9 6.3 4e-11 43.1 6.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOO30262.1 - 4.1e-07 29.6 1.8 9.1e-07 28.5 1.8 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 KOO30262.1 - 7e-07 29.4 8.2 1.2e-05 25.5 8.2 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KOO30262.1 - 1.7e-06 27.7 6.4 3e-06 27.0 6.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO30262.1 - 4.1e-06 26.6 5.1 7.2e-06 25.8 5.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO30262.1 - 4.9e-05 23.2 7.3 8.2e-05 22.5 7.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO30262.1 - 0.00022 21.2 0.2 0.00022 21.2 0.2 1.9 1 1 1 2 2 2 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 KOO30262.1 - 0.00061 19.4 6.3 0.0012 18.5 6.3 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 KOO30262.1 - 0.0038 17.1 7.5 0.0061 16.4 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 KOO30262.1 - 0.014 15.3 0.3 0.014 15.3 0.3 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Prok-RING_4 PF14447.6 KOO30262.1 - 0.018 14.9 5.8 0.018 14.9 5.8 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zinc_ribbon_16 PF17034.5 KOO30262.1 - 0.047 13.9 1.2 0.086 13.1 1.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon like family Ferritin_2 PF13668.6 KOO30262.1 - 0.11 12.7 0.4 0.93 9.7 1.4 2.1 2 1 0 2 2 2 0 Ferritin-like domain zf-ANAPC11 PF12861.7 KOO30262.1 - 0.14 12.2 6.8 1.3 9.1 6.7 2.2 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Sin_N PF04801.13 KOO30262.1 - 0.16 11.2 2.4 0.2 10.8 2.4 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region RINGv PF12906.7 KOO30262.1 - 0.2 11.8 6.2 0.43 10.7 6.2 1.5 1 0 0 1 1 1 0 RING-variant domain PHD PF00628.29 KOO30262.1 - 0.44 10.5 7.6 0.69 9.8 7.1 1.7 1 1 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 KOO30262.1 - 7.6 6.8 9.5 9.9 6.4 7.7 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain ESSS PF10183.9 KOO30263.1 - 5.7e-06 26.5 0.1 8.6e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) ABM PF03992.16 KOO30263.1 - 0.13 12.4 0.2 0.43 10.7 0.0 2.0 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase MIG-14_Wnt-bd PF06664.12 KOO30264.1 - 1.3e-32 113.2 0.6 1.8e-32 112.7 0.6 1.1 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion HisKA_7TM PF16927.5 KOO30264.1 - 0.051 13.6 13.5 0.053 13.5 3.1 2.4 1 1 1 2 2 2 0 N-terminal 7TM region of histidine kinase PP2C PF00481.21 KOO30265.1 - 2.1e-46 158.7 0.6 2.1e-45 155.4 0.6 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C FAD_binding_4 PF01565.23 KOO30266.1 - 9.5e-16 57.8 0.4 1.6e-15 57.1 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 KOO30266.1 - 1.6e-13 51.1 0.0 2.5e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase RL10P_insert PF17777.1 KOO30267.1 - 6.7e-26 90.1 0.0 1.3e-25 89.2 0.0 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 KOO30267.1 - 1.9e-13 50.4 0.0 2.9e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 CENP-H PF05837.12 KOO30268.1 - 0.022 15.2 17.6 0.16 12.4 4.5 3.1 2 1 1 3 3 3 0 Centromere protein H (CENP-H) SOGA PF11365.8 KOO30268.1 - 0.096 13.8 1.3 0.096 13.8 1.3 2.8 2 1 0 2 2 2 0 Protein SOGA OmpH PF03938.14 KOO30268.1 - 0.098 13.0 20.9 0.031 14.6 10.8 2.8 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Defensin_propep PF00879.18 KOO30268.1 - 0.12 12.6 8.2 3.7 7.9 5.6 3.1 2 0 0 2 2 2 0 Defensin propeptide rRNA_proc-arch PF13234.6 KOO30268.1 - 1.3 8.9 9.0 1.6 8.6 0.6 3.0 3 0 0 3 3 3 0 rRNA-processing arch domain PKcGMP_CC PF16808.5 KOO30268.1 - 2 8.3 5.7 25 4.8 0.3 3.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Ank_4 PF13637.6 KOO30269.1 - 2.9e-10 40.5 2.6 4.2e-07 30.4 0.3 1.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO30269.1 - 6.3e-10 39.1 0.2 1.3e-09 38.1 0.2 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO30269.1 - 2e-09 37.9 0.1 4.6e-09 36.8 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO30269.1 - 1.7e-06 28.2 0.2 4.2e-06 27.0 0.2 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 KOO30269.1 - 2e-06 27.7 0.1 7e-06 26.0 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeat DUF3798 PF12683.7 KOO30269.1 - 0.064 12.7 0.0 0.14 11.6 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3798) YdaS_antitoxin PF15943.5 KOO30270.1 - 0.0016 18.3 0.0 0.0036 17.1 0.0 1.6 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_3 PF01381.22 KOO30270.1 - 0.048 13.7 0.0 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix HTH_31 PF13560.6 KOO30270.1 - 0.1 12.9 0.2 0.1 12.9 0.2 2.8 2 1 0 2 2 2 0 Helix-turn-helix domain EF-hand_1 PF00036.32 KOO30273.1 - 1e-13 49.7 4.0 1.4e-06 27.4 0.2 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO30273.1 - 1.9e-10 40.4 0.6 0.0038 17.0 0.2 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 KOO30273.1 - 1.3e-09 38.4 0.7 0.00018 21.9 0.2 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO30273.1 - 2.1e-09 36.6 1.3 0.0032 17.3 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KOO30273.1 - 6.1e-07 28.7 6.9 0.0031 17.0 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.7 KOO30273.1 - 0.00011 22.1 0.3 0.78 9.7 0.0 3.1 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand Sel1 PF08238.12 KOO30274.1 - 2.1e-12 47.3 6.4 4.3e-05 24.0 1.6 3.6 3 0 0 3 3 3 3 Sel1 repeat U-box PF04564.15 KOO30274.1 - 5e-10 39.4 0.0 9.2e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO30274.1 - 0.00078 19.2 0.1 0.0027 17.5 0.0 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO30274.1 - 0.0018 18.3 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein CZB PF13682.6 KOO30274.1 - 0.058 13.9 0.4 0.058 13.9 0.4 2.0 2 0 0 2 2 2 0 Chemoreceptor zinc-binding domain ADK PF00406.22 KOO30275.1 - 7.2e-72 240.4 0.1 6.6e-39 133.4 0.0 2.7 3 0 0 3 3 3 2 Adenylate kinase AAA_17 PF13207.6 KOO30275.1 - 1e-50 171.7 0.6 1.4e-28 100.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 KOO30275.1 - 5.9e-10 39.5 0.0 0.00022 21.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KOO30275.1 - 8.9e-10 39.2 0.0 0.0021 18.6 0.0 2.8 2 1 0 2 2 2 2 AAA domain EF-hand_7 PF13499.6 KOO30275.1 - 6.2e-09 36.2 0.1 2.5e-08 34.2 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair 5_nucleotid_C PF02872.18 KOO30275.1 - 8.8e-09 35.8 0.0 1.9e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain EF-hand_1 PF00036.32 KOO30275.1 - 1e-07 31.0 4.5 0.0014 18.0 0.0 3.3 3 0 0 3 3 3 2 EF hand Thymidylate_kin PF02223.17 KOO30275.1 - 2.5e-07 30.6 4.2 0.03 14.0 0.1 3.5 3 0 0 3 3 3 2 Thymidylate kinase EF-hand_6 PF13405.6 KOO30275.1 - 2.8e-07 29.9 0.4 0.021 14.7 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO30275.1 - 1.2e-06 27.7 3.7 0.0073 15.8 0.1 2.7 2 0 0 2 2 2 2 EF hand Hydin_ADK PF17213.3 KOO30275.1 - 0.00014 22.2 0.1 0.64 10.3 0.0 2.4 2 0 0 2 2 2 2 Hydin Adenylate kinase-like domain SRP54 PF00448.22 KOO30275.1 - 0.00027 20.6 0.1 0.43 10.2 0.0 2.5 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain EF-hand_8 PF13833.6 KOO30275.1 - 0.00044 20.1 0.9 0.03 14.2 0.1 2.9 1 1 0 2 2 2 1 EF-hand domain pair Ploopntkinase3 PF18751.1 KOO30275.1 - 0.0012 18.7 0.1 1.7 8.5 0.0 2.4 2 0 0 2 2 2 2 P-loop Nucleotide Kinase3 AAA PF00004.29 KOO30275.1 - 0.0048 17.3 0.3 7.1 7.1 0.0 3.6 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 KOO30275.1 - 0.0066 16.8 0.4 1 9.7 0.1 2.6 2 0 0 2 2 2 1 AAA domain NFACT-R_2 PF18297.1 KOO30275.1 - 0.048 13.9 0.0 9.4 6.5 0.0 2.9 2 0 0 2 2 2 0 NFACT protein RNA binding domain AAA_28 PF13521.6 KOO30275.1 - 0.094 12.9 0.1 15 5.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain Metallophos PF00149.28 KOO30275.1 - 0.17 12.4 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase AAA_16 PF13191.6 KOO30275.1 - 0.24 11.8 0.4 51 4.2 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain Cytidylate_kin PF02224.18 KOO30275.1 - 0.92 9.2 2.3 3.5 7.3 0.0 2.7 3 0 0 3 3 3 0 Cytidylate kinase FOXP-CC PF16159.5 KOO30277.1 - 0.024 15.3 0.1 0.042 14.5 0.1 1.4 1 0 0 1 1 1 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 KOO30277.1 - 0.19 11.8 0.0 0.27 11.3 0.0 1.1 1 0 0 1 1 1 0 Aberrant zinc-finger Pilosulin PF17499.2 KOO30278.1 - 0.52 10.5 0.1 0.52 10.5 0.1 1.9 2 1 1 3 3 3 0 Ant venom peptides VIR_N PF15912.5 KOO30278.1 - 5.1 6.6 6.6 9.4 5.7 6.6 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal NPV_P10 PF05531.12 KOO30279.1 - 2.7 8.5 8.0 1.2 9.6 1.5 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein 2OG-FeII_Oxy_4 PF13661.6 KOO30280.1 - 0.0017 19.0 0.0 0.0047 17.6 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Dus PF01207.17 KOO30281.1 - 5.9e-43 147.1 1.7 9.7e-43 146.4 0.0 1.9 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) Peptidase_M10 PF00413.24 KOO30281.1 - 6.5e-05 22.8 0.0 0.0005 19.9 0.0 2.4 3 1 0 3 3 3 1 Matrixin YscJ_FliF PF01514.17 KOO30281.1 - 0.011 15.4 0.6 0.023 14.4 0.6 1.4 1 0 0 1 1 1 0 Secretory protein of YscJ/FliF family Astacin PF01400.24 KOO30281.1 - 0.51 9.9 3.2 0.29 10.7 0.8 1.8 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) PPR_2 PF13041.6 KOO30282.1 - 8.3e-38 128.4 0.0 4.2e-05 23.7 0.0 10.6 10 1 1 11 11 11 6 PPR repeat family PPR PF01535.20 KOO30282.1 - 1.1e-31 106.8 2.1 0.0029 17.8 0.0 13.1 13 0 0 13 13 13 4 PPR repeat BNR_2 PF13088.6 KOO30282.1 - 5.1e-16 58.8 0.0 1.1e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain PPR_3 PF13812.6 KOO30282.1 - 1.1e-11 44.6 0.0 0.75 9.9 0.0 8.6 8 1 1 9 9 9 1 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO30282.1 - 1.1e-10 41.3 13.6 0.093 12.1 0.1 6.7 3 2 2 6 6 6 4 Pentacotripeptide-repeat region of PRORP BNR PF02012.20 KOO30282.1 - 1.5e-05 24.3 7.9 0.59 10.4 0.1 4.0 3 0 0 3 3 3 3 BNR/Asp-box repeat TPR_7 PF13176.6 KOO30282.1 - 0.00025 20.9 3.1 27 5.1 0.0 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat PPR_1 PF12854.7 KOO30282.1 - 0.00076 19.1 3.7 1.1 9.1 0.0 5.4 7 0 0 7 7 7 1 PPR repeat CesT PF05932.13 KOO30282.1 - 0.075 13.2 0.1 0.34 11.1 0.1 2.1 1 0 0 1 1 1 0 Tir chaperone protein (CesT) family TPR_19 PF14559.6 KOO30282.1 - 0.12 12.8 27.9 0.34 11.4 0.4 7.2 5 2 1 7 7 7 0 Tetratricopeptide repeat FtsK_gamma PF09397.10 KOO30282.1 - 0.17 11.7 0.3 5.1 7.0 0.0 2.8 2 0 0 2 2 2 0 Ftsk gamma domain TPR_14 PF13428.6 KOO30282.1 - 1 10.4 60.2 0.85 10.6 0.5 13.1 8 3 6 14 14 14 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 KOO30283.1 - 1.8e-07 30.2 0.0 0.084 12.5 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KOO30283.1 - 2.5e-07 29.9 0.2 0.0064 15.9 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO30283.1 - 9.8e-07 28.2 0.4 0.079 12.9 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO30283.1 - 3.1e-06 27.5 0.4 0.00018 21.9 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair IQ PF00612.27 KOO30283.1 - 0.022 14.5 0.2 0.058 13.2 0.2 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif EF-hand_8 PF13833.6 KOO30283.1 - 0.023 14.5 0.6 7.6 6.5 0.0 3.4 2 1 2 4 4 4 0 EF-hand domain pair DUF3275 PF11679.8 KOO30283.1 - 0.75 9.7 4.7 1.2 9.1 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Med3 PF11593.8 KOO30283.1 - 1.4 8.0 3.3 2.4 7.3 3.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-RING_2 PF13639.6 KOO30286.1 - 1.8e-06 28.2 10.2 1.8e-06 28.2 10.2 1.7 2 0 0 2 2 1 1 Ring finger domain FANCL_C PF11793.8 KOO30286.1 - 1.2e-05 25.4 7.0 3.1e-05 24.1 7.0 1.7 1 1 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 KOO30286.1 - 0.0026 17.8 6.5 0.0059 16.6 6.5 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 KOO30286.1 - 0.014 15.5 7.2 0.035 14.2 7.2 1.8 1 0 0 1 1 1 0 RING-variant domain zf-rbx1 PF12678.7 KOO30286.1 - 0.018 15.3 11.9 0.1 12.9 12.2 2.0 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOO30286.1 - 0.02 14.8 10.6 0.044 13.7 10.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 KOO30286.1 - 0.1 12.9 8.4 0.06 13.7 5.4 2.1 2 0 0 2 2 2 0 RING-like domain SIR2 PF02146.17 KOO30286.1 - 0.14 12.0 0.2 0.22 11.4 0.2 1.3 1 0 0 1 1 1 0 Sir2 family PHD PF00628.29 KOO30286.1 - 0.17 11.8 7.5 0.32 10.9 7.5 1.5 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 KOO30286.1 - 0.28 10.8 9.4 0.32 10.6 7.6 2.0 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 KOO30286.1 - 0.31 11.0 9.6 0.061 13.2 4.8 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_4 PF16866.5 KOO30286.1 - 0.48 10.6 8.9 6.5 6.9 3.8 2.6 1 1 1 2 2 2 0 PHD-finger Prok-RING_4 PF14447.6 KOO30286.1 - 1.6 8.6 10.6 6.9 6.6 5.2 3.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KOO30286.1 - 1.7 8.6 9.3 8.2 6.4 9.4 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) GAGA PF09237.11 KOO30286.1 - 1.7 8.5 6.9 7.4 6.5 0.4 2.4 1 1 1 2 2 2 0 GAGA factor zf-C3HC4_2 PF13923.6 KOO30286.1 - 4.1 7.3 15.8 3.5 7.6 13.2 2.3 2 1 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO30286.1 - 4.9 7.3 8.2 14 5.9 8.2 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Laminin_II PF06009.12 KOO30287.1 - 0.00071 19.6 1.4 0.0015 18.5 1.1 1.7 1 1 1 2 2 2 1 Laminin Domain II Pex26 PF07163.12 KOO30287.1 - 0.0017 17.7 3.1 0.0022 17.4 3.1 1.1 1 0 0 1 1 1 1 Pex26 protein Rrp15p PF07890.12 KOO30287.1 - 0.012 15.9 0.2 3 8.2 0.0 2.1 1 1 1 2 2 2 0 Rrp15p DUF2721 PF11026.8 KOO30287.1 - 0.39 10.6 7.4 0.045 13.6 2.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Ion_trans PF00520.31 KOO30288.1 - 2.4e-80 269.3 39.5 8e-38 130.0 9.9 3.4 3 1 0 3 3 3 3 Ion transport protein EF-hand_1 PF00036.32 KOO30288.1 - 0.00016 21.0 0.0 0.0011 18.4 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO30288.1 - 0.00067 19.0 0.0 0.0016 17.9 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO30288.1 - 0.011 16.2 0.0 0.025 15.0 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair PKD_channel PF08016.12 KOO30288.1 - 1.3 7.6 36.7 0.082 11.6 1.2 5.7 4 2 2 6 6 6 0 Polycystin cation channel PDZ_6 PF17820.1 KOO30289.1 - 2.1e-06 27.5 0.1 4.2e-06 26.5 0.1 1.5 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KOO30289.1 - 9.7e-05 22.7 0.1 0.00018 21.8 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO30289.1 - 0.00026 21.3 0.2 0.00039 20.7 0.2 1.4 1 1 0 1 1 1 1 PDZ domain Pcc1 PF09341.10 KOO30289.1 - 0.069 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Transcription factor Pcc1 Glyco_transf_34 PF05637.12 KOO30290.1 - 0.096 12.4 0.2 0.18 11.5 0.2 1.3 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family EF-hand_1 PF00036.32 KOO30292.1 - 2.2e-18 64.4 10.5 8.7e-05 21.8 0.9 5.3 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO30292.1 - 1.7e-17 63.6 5.2 4.6e-08 33.4 0.1 4.0 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO30292.1 - 4e-15 54.4 12.8 0.00042 20.0 0.0 5.6 6 0 0 6 6 6 3 EF-hand domain EF-hand_8 PF13833.6 KOO30292.1 - 2.7e-13 49.5 9.3 6.2e-06 26.0 0.5 5.0 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO30292.1 - 1.1e-09 37.3 11.5 0.00067 19.0 0.0 4.7 4 0 0 4 4 4 2 EF hand GSCFA PF08885.11 KOO30292.1 - 5e-06 26.4 1.2 5.7e-06 26.2 0.1 1.7 2 0 0 2 2 2 1 GSCFA family Caleosin PF05042.13 KOO30292.1 - 0.031 14.2 0.0 13 5.7 0.0 2.8 2 1 0 2 2 2 0 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO30292.1 - 0.071 13.4 0.1 6.9 7.0 0.0 3.3 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO30292.1 - 0.16 11.8 1.4 13 5.8 0.0 3.3 3 0 0 3 3 3 0 EF hand PIP5K PF01504.18 KOO30293.1 - 3e-58 197.2 0.0 3e-57 193.9 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Siah-Interact_N PF09032.11 KOO30293.1 - 0.0078 16.5 0.1 0.016 15.5 0.1 1.5 1 0 0 1 1 1 1 Siah interacting protein, N terminal Git3 PF11710.8 KOO30293.1 - 0.032 14.0 0.5 0.064 13.0 0.5 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 HMG_box PF00505.19 KOO30297.1 - 1.4e-07 31.8 0.7 1.4e-07 31.8 0.7 3.3 2 2 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO30297.1 - 0.0012 19.3 0.3 0.0012 19.3 0.3 3.1 2 2 1 3 3 3 1 HMG-box domain PHD20L1_u1 PF16660.5 KOO30297.1 - 0.11 13.3 0.2 0.11 13.3 0.2 3.3 4 1 0 4 4 4 0 PHD finger protein 20-like protein 1 SHIPPO-rpt PF07004.12 KOO30298.1 - 4.5e-13 49.4 10.0 0.087 13.8 0.3 7.5 7 0 0 7 7 7 4 Sperm-tail PG-rich repeat Fasciclin PF02469.22 KOO30299.1 - 1.6e-63 212.6 0.6 7.6e-31 107.0 0.1 2.1 2 0 0 2 2 2 2 Fasciclin domain HydF_dimer PF18128.1 KOO30299.1 - 7.9e-05 22.7 0.4 0.51 10.4 0.1 2.5 2 0 0 2 2 2 2 Hydrogen maturase F dimerization domain AbiEi_1 PF09407.10 KOO30299.1 - 0.59 10.4 4.2 2 8.7 0.6 2.5 2 0 0 2 2 2 0 AbiEi antitoxin C-terminal domain CSD PF00313.22 KOO30300.1 - 2.2e-12 46.7 0.0 3.4e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCCH PF00642.24 KOO30300.1 - 0.00041 20.2 0.2 0.00041 20.2 0.2 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KOO30300.1 - 0.00078 19.2 0.4 0.0015 18.3 0.4 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOO30300.1 - 0.00095 19.1 1.1 0.0022 18.0 1.1 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_2 PF14608.6 KOO30300.1 - 0.36 11.4 0.1 0.36 11.4 0.1 1.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger JmjC PF02373.22 KOO30301.1 - 1.4e-33 115.7 0.1 2.4e-33 115.0 0.1 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 KOO30301.1 - 5.2e-11 42.3 0.3 1.1e-10 41.3 0.3 1.6 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 KOO30301.1 - 0.11 12.9 2.8 0.15 12.5 0.1 2.3 2 0 0 2 2 2 0 C5HC2 zinc finger NDK PF00334.19 KOO30302.1 - 3e-23 82.3 0.0 1.5e-22 80.0 0.0 1.9 2 0 0 2 2 2 1 Nucleoside diphosphate kinase DUF1126 PF06565.12 KOO30302.1 - 6.2e-05 22.8 0.1 0.00011 22.0 0.1 1.4 1 0 0 1 1 1 1 DUF1126 PH-like domain YdaS_antitoxin PF15943.5 KOO30302.1 - 0.085 12.7 0.0 0.31 10.9 0.0 2.0 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT VCBS PF13517.6 KOO30303.1 - 5.3e-21 75.0 1.6 2.2e-13 50.6 0.2 2.8 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO30303.1 - 7.7e-12 45.1 13.9 0.0011 19.1 0.2 4.2 3 0 0 3 3 3 3 FG-GAP repeat Ank_5 PF13857.6 KOO30303.1 - 6.7e-07 29.5 0.4 0.081 13.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO30303.1 - 0.0012 19.2 0.6 3.9 8.4 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 KOO30303.1 - 0.0018 18.8 0.0 1.2 9.8 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO30303.1 - 0.027 15.1 0.2 5.1 7.8 0.2 2.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) BBS2_Mid PF14783.6 KOO30303.1 - 0.038 14.0 0.0 4.8 7.3 0.0 3.1 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region TcdB_toxin_midN PF12256.8 KOO30303.1 - 0.34 10.3 1.9 15 4.9 0.1 2.5 1 1 1 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region EF-hand_5 PF13202.6 KOO30303.1 - 2.1 8.0 4.1 11 5.7 0.2 2.5 2 0 0 2 2 2 0 EF hand Mito_carr PF00153.27 KOO30305.1 - 5.2e-37 125.7 8.1 1.5e-15 56.9 0.1 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Metallophos PF00149.28 KOO30306.1 - 1.1e-17 65.2 0.0 1.9e-17 64.5 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 KOO30306.1 - 3.9e-15 56.5 0.0 1.1e-14 55.0 0.0 1.8 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C DUF2169 PF09937.9 KOO30306.1 - 0.034 13.6 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2169) TauE PF01925.19 KOO30306.1 - 0.076 12.6 0.2 0.13 11.9 0.2 1.3 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE PGA_cap PF09587.10 KOO30306.1 - 0.18 11.2 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap PBP1_TM PF14812.6 KOO30307.1 - 0.018 15.4 0.8 0.022 15.1 0.8 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UQ_con PF00179.26 KOO30308.1 - 1.6e-14 53.7 0.0 9.7e-14 51.2 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_A PF14457.6 KOO30308.1 - 0.0038 16.9 0.0 0.0059 16.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family A Prok-E2_B PF14461.6 KOO30308.1 - 0.072 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B LAT PF15234.6 KOO30308.1 - 0.26 11.0 5.0 0.43 10.3 4.7 1.4 1 1 0 1 1 1 0 Linker for activation of T-cells PBP1_TM PF14812.6 KOO30308.1 - 0.65 10.4 7.3 1.1 9.7 7.3 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 KOO30308.1 - 1.6 6.8 9.7 2 6.4 9.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 KOO30308.1 - 2.9 8.3 13.1 6.4 7.2 13.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Nop14 PF04147.12 KOO30308.1 - 3.5 5.7 4.8 4 5.5 4.8 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 KOO30308.1 - 5.4 6.2 9.9 7.5 5.8 9.9 1.1 1 0 0 1 1 1 0 NOA36 protein E1-E2_ATPase PF00122.20 KOO30309.1 - 7.8e-41 139.6 3.0 7.8e-41 139.6 3.0 2.9 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 KOO30309.1 - 1.3e-19 71.3 0.1 7.5e-19 68.8 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOO30309.1 - 2.4e-09 36.7 0.0 6.3e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOO30309.1 - 0.00037 20.3 0.5 0.0028 17.5 0.2 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOO30309.1 - 0.00099 19.2 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) HAD PF12710.7 KOO30309.1 - 0.12 12.7 0.1 0.43 10.9 0.0 2.1 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase PsbI PF02532.14 KOO30309.1 - 0.59 10.1 2.6 2.1 8.4 2.6 1.9 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Sp38 PF07354.12 KOO30310.1 - 0.051 13.0 0.0 0.51 9.8 0.0 2.0 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) Phage_int_SAM_1 PF02899.17 KOO30311.1 - 0.088 13.1 3.2 0.18 12.1 3.2 1.6 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Ndc1_Nup PF09531.10 KOO30311.1 - 1 8.0 4.4 1.3 7.7 4.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Diphthami_syn_2 PF01902.17 KOO30312.1 - 0.098 12.1 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Diphthamide synthase Methyltransf_15 PF09445.10 KOO30313.1 - 1.6e-41 141.7 0.0 2e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Gemin7 PF11095.8 KOO30313.1 - 6.2e-07 29.2 0.0 1.1e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Gem-associated protein 7 (Gemin7) Methyltransf_25 PF13649.6 KOO30313.1 - 0.00022 21.9 0.0 0.00089 19.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 KOO30313.1 - 0.00026 20.8 0.0 0.00054 19.8 0.0 1.3 1 1 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.18 KOO30313.1 - 0.00031 20.5 0.0 0.0005 19.8 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.15 KOO30313.1 - 0.00048 19.8 0.0 0.00068 19.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 KOO30313.1 - 0.058 12.9 0.0 0.087 12.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain RrnaAD PF00398.20 KOO30313.1 - 0.083 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase IF3_C PF00707.22 KOO30315.1 - 4.7e-08 32.9 0.0 7.9e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 KOO30315.1 - 2.9e-07 30.6 0.2 8e-07 29.2 0.1 1.7 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain GTP_EFTU PF00009.27 KOO30316.1 - 6.1e-60 202.1 0.0 9.3e-60 201.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KOO30316.1 - 1.4e-38 131.4 0.0 3.1e-38 130.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 KOO30316.1 - 2.1e-29 101.4 0.0 4.8e-29 100.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KOO30316.1 - 7.9e-23 80.3 0.1 1.9e-22 79.1 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOO30316.1 - 1.4e-11 44.6 0.0 3.6e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 KOO30316.1 - 1.1e-05 25.2 0.0 2.9e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 KOO30316.1 - 0.00015 21.8 0.0 0.00036 20.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 KOO30316.1 - 0.0063 15.9 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 AIG1 family PIF3 PF05006.12 KOO30316.1 - 0.024 14.7 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Per os infectivity factor 3 MobB PF03205.14 KOO30316.1 - 0.15 12.0 0.2 17 5.3 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AvrPtoB_bdg PF16847.5 KOO30316.1 - 0.15 12.5 0.0 0.82 10.2 0.0 2.2 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain Amidohydro_2 PF04909.14 KOO30317.1 - 4.1e-25 89.2 0.6 5.2e-25 88.8 0.6 1.1 1 0 0 1 1 1 1 Amidohydrolase IQ PF00612.27 KOO30318.1 - 2.8e-05 23.5 52.0 0.63 10.0 0.0 11.9 12 0 0 12 12 12 6 IQ calmodulin-binding motif UBA_4 PF14555.6 KOO30318.1 - 0.045 13.6 0.1 1.7 8.5 0.0 2.7 2 0 0 2 2 2 0 UBA-like domain MAAL_C PF07476.11 KOO30318.1 - 0.22 10.6 4.4 0.31 10.2 0.2 2.9 2 1 1 3 3 3 0 Methylaspartate ammonia-lyase C-terminus PheRS_DBD2 PF18554.1 KOO30318.1 - 1.1 9.3 10.4 50 4.0 0.2 4.8 4 0 0 4 4 4 0 PheRS DNA binding domain 2 GST_C_3 PF14497.6 KOO30319.1 - 2e-11 44.0 0.0 4.1e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOO30319.1 - 9.4e-08 32.3 0.0 2.2e-07 31.1 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO30319.1 - 0.0011 19.3 0.0 0.0021 18.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO30319.1 - 0.0015 18.5 0.2 0.0033 17.4 0.2 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 KOO30319.1 - 0.066 13.5 0.0 0.18 12.1 0.0 1.8 1 1 1 2 2 2 0 Outer mitochondrial membrane transport complex protein GST_N_3 PF13417.6 KOO30319.1 - 0.085 13.3 0.0 0.28 11.6 0.0 1.9 2 1 0 2 2 2 0 Glutathione S-transferase, N-terminal domain HC2 PF07382.11 KOO30320.1 - 0.021 14.9 18.5 0.021 14.9 18.5 1.0 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 HC2 PF07382.11 KOO30321.1 - 0.012 15.7 14.2 0.012 15.7 14.2 1.0 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Hc1 PF07432.13 KOO30321.1 - 0.52 10.7 14.5 0.49 10.8 14.5 1.0 1 0 0 1 1 1 0 Histone H1-like protein Hc1 DUF4573 PF15140.6 KOO30323.1 - 0.062 13.1 0.6 0.078 12.8 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4573) 6PF2K PF01591.18 KOO30325.1 - 5.8e-37 127.2 0.1 1.1e-36 126.3 0.1 1.5 1 1 1 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOO30325.1 - 6.8e-31 107.5 0.0 1.2e-30 106.7 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) FTA4 PF13093.6 KOO30325.1 - 0.13 12.1 0.1 0.33 10.8 0.0 1.7 2 0 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 NCBP3 PF10309.9 KOO30326.1 - 2.7e-17 62.3 0.0 4.8e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Tho1_MOS11_C PF18592.1 KOO30326.1 - 0.00054 19.7 0.0 0.78 9.6 0.0 2.8 2 0 0 2 2 2 2 Tho1/MOS11 C-terminal domain SPT6_acidic PF14632.6 KOO30326.1 - 0.0016 19.0 2.0 0.003 18.1 2.0 1.4 1 0 0 1 1 1 1 Acidic N-terminal SPT6 RNA_bind PF08675.11 KOO30326.1 - 0.21 11.6 0.0 0.36 10.9 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain Ribosomal_S10 PF00338.22 KOO30327.1 - 2.1e-14 53.5 0.1 2.8e-14 53.1 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S10p/S20e DLIC PF05783.11 KOO30329.1 - 3.5e-14 52.5 0.0 3.4e-08 32.8 0.0 2.1 1 1 0 2 2 2 2 Dynein light intermediate chain (DLIC) Roc PF08477.13 KOO30329.1 - 6e-07 29.7 0.0 2.6e-06 27.6 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO30329.1 - 7.2e-05 22.4 0.0 0.00028 20.5 0.0 1.9 2 0 0 2 2 2 1 Ras family Dynamin_N PF00350.23 KOO30329.1 - 0.00055 20.0 0.1 0.0019 18.3 0.0 1.9 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 KOO30329.1 - 0.0035 17.4 0.0 0.0073 16.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 KOO30329.1 - 0.0052 16.1 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 Septin Arf PF00025.21 KOO30329.1 - 0.012 15.1 0.0 0.24 10.8 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family Plasmid_stab_B PF10784.9 KOO30329.1 - 0.016 15.0 0.3 0.037 13.9 0.3 1.5 1 0 0 1 1 1 0 Plasmid stability protein GTP_EFTU PF00009.27 KOO30329.1 - 0.023 14.2 0.0 1.2 8.6 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Pilt PF15453.6 KOO30329.1 - 0.028 13.8 0.1 0.037 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions G-alpha PF00503.20 KOO30329.1 - 0.051 12.7 0.0 0.24 10.5 0.0 2.3 1 1 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 KOO30329.1 - 0.054 13.3 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO30329.1 - 0.058 13.3 0.0 0.7 9.8 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase ATP_bind_1 PF03029.17 KOO30329.1 - 0.072 12.9 0.0 2.7 7.7 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF1515 PF07439.11 KOO30329.1 - 0.11 12.6 0.4 0.23 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) tRNA-synt_1g PF09334.11 KOO30330.1 - 7e-104 347.7 0.1 1.7e-61 208.1 0.0 2.2 1 1 1 2 2 2 2 tRNA synthetases class I (M) PPR_2 PF13041.6 KOO30330.1 - 2.4e-80 264.5 0.0 2.2e-12 47.0 0.0 12.3 5 3 8 13 13 13 12 PPR repeat family PPR_3 PF13812.6 KOO30330.1 - 2.3e-62 206.9 0.0 1.3e-11 44.4 0.0 8.8 8 1 1 9 9 9 7 Pentatricopeptide repeat domain PPR_1 PF12854.7 KOO30330.1 - 1e-56 188.3 1.7 1.2e-08 34.5 0.0 10.9 12 0 0 12 12 12 8 PPR repeat PPR PF01535.20 KOO30330.1 - 6.1e-56 182.9 0.4 2.2e-05 24.4 0.0 12.6 13 0 0 13 13 13 10 PPR repeat PPR_long PF17177.4 KOO30330.1 - 4.8e-42 143.7 13.1 5e-11 42.4 0.0 5.9 2 2 4 6 6 6 5 Pentacotripeptide-repeat region of PRORP tRNA-synt_1 PF00133.22 KOO30330.1 - 1.6e-29 102.7 0.0 8.3e-13 47.4 0.0 4.1 3 1 1 4 4 4 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 KOO30330.1 - 7.7e-13 48.5 0.0 1e-05 25.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain CDC73_N PF16050.5 KOO30330.1 - 0.03 13.7 1.8 0.053 12.8 1.8 1.3 1 0 0 1 1 1 0 Paf1 complex subunit CDC73 N-terminal ECSIT PF06239.11 KOO30330.1 - 0.041 13.0 0.0 4 6.5 0.0 3.2 3 0 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway tRNA-synt_1f PF01921.18 KOO30330.1 - 0.13 11.1 0.0 1.8 7.4 0.0 2.4 3 0 0 3 3 3 0 tRNA synthetases class I (K) Enolase_C PF00113.22 KOO30331.1 - 4.5e-129 429.9 0.0 5.8e-129 429.5 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KOO30331.1 - 3.5e-53 179.3 0.2 5.7e-53 178.6 0.2 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MAAL_C PF07476.11 KOO30331.1 - 6.4e-06 25.5 0.7 6.4e-06 25.5 0.7 1.8 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus MR_MLE_C PF13378.6 KOO30331.1 - 0.00011 21.8 0.0 0.00022 20.8 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like Roc PF08477.13 KOO30331.1 - 0.013 15.7 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RPGR1_C PF18111.1 KOO30332.1 - 4.4e-07 29.9 0.0 1.1e-05 25.4 0.0 2.6 2 1 0 2 2 2 1 Retinitis pigmentosa G-protein regulator interacting C-terminal DUF1471 PF07338.13 KOO30333.1 - 1 9.4 6.2 22 5.1 0.8 5.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1471) SsgA PF04686.12 KOO30333.1 - 2.2 8.3 6.9 0.56 10.3 0.6 3.0 3 0 0 3 3 3 0 Streptomyces sporulation and cell division protein, SsgA DRY_EERY PF09750.9 KOO30334.1 - 0.25 11.6 1.6 0.59 10.4 1.6 1.6 1 0 0 1 1 1 0 Alternative splicing regulator PUF PF00806.19 KOO30335.1 - 5.4e-17 60.4 0.0 0.0041 16.7 0.0 6.2 7 0 0 7 7 7 5 Pumilio-family RNA binding repeat EF-hand_6 PF13405.6 KOO30336.1 - 7.3e-15 53.6 1.0 0.00017 21.2 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO30336.1 - 1.8e-14 52.1 1.4 0.0023 17.4 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO30336.1 - 5e-12 46.1 0.2 1.9e-06 28.2 0.5 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO30336.1 - 1.8e-10 40.5 0.4 2.9e-07 30.2 0.3 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO30336.1 - 1.1e-06 27.8 10.8 0.098 12.2 0.0 3.7 4 0 0 4 4 4 3 EF hand V-SNARE PF05008.15 KOO30336.1 - 0.1 13.0 0.7 0.36 11.2 0.7 1.8 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus EF-hand_4 PF12763.7 KOO30336.1 - 0.17 11.9 1.1 77 3.3 0.0 3.2 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO30336.1 - 0.21 11.5 2.9 19 5.2 0.1 3.8 3 2 1 5 5 5 0 EF hand LCM PF04072.14 KOO30337.1 - 2.2e-20 73.4 0.0 3.5e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase GARS_A PF01071.19 KOO30338.1 - 2.6e-45 154.6 0.0 4e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.19 KOO30338.1 - 3.5e-41 140.9 0.0 5e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase GARS_C PF02843.16 KOO30338.1 - 3e-12 46.6 0.2 9.9e-12 45.0 0.0 2.0 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_2 PF08442.10 KOO30338.1 - 0.019 14.6 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain FGE-sulfatase PF03781.16 KOO30339.1 - 7.5e-27 94.5 0.2 1.5e-26 93.5 0.2 1.5 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 C_tripleX PF02363.19 KOO30340.1 - 2 8.8 5.5 3.6 8.1 0.8 4.1 2 0 0 2 2 2 0 Cysteine rich repeat PMC2NT PF08066.12 KOO30341.1 - 1.2 9.9 9.7 1.3 9.7 2.4 3.3 2 1 1 3 3 3 0 PMC2NT (NUC016) domain RmuC PF02646.16 KOO30341.1 - 1.5 7.9 19.7 0.077 12.1 4.7 3.4 2 1 2 4 4 4 0 RmuC family MAD PF05557.13 KOO30341.1 - 3.3 6.0 35.6 1.2 7.4 26.1 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF724 PF05266.14 KOO30341.1 - 7 6.4 26.8 1.4 8.7 1.1 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF724) Tic22 PF04278.12 KOO30342.1 - 8e-06 25.4 0.0 0.01 15.2 0.0 2.3 2 0 0 2 2 2 2 Tic22-like family IQ PF00612.27 KOO30343.1 - 9.2e-07 28.1 0.2 0.04 13.7 0.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif PH PF00169.29 KOO30343.1 - 0.046 14.2 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 PH domain Golgin_A5 PF09787.9 KOO30344.1 - 0.02 14.4 10.2 0.013 15.0 8.4 1.5 1 1 0 1 1 1 0 Golgin subfamily A member 5 TMF_DNA_bd PF12329.8 KOO30344.1 - 0.038 14.0 0.8 0.038 14.0 0.8 3.9 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding HAUS6_N PF14661.6 KOO30344.1 - 0.078 12.6 4.1 0.11 12.1 4.1 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus FAM76 PF16046.5 KOO30344.1 - 0.14 11.5 12.2 1.6 8.0 0.5 2.2 2 0 0 2 2 2 0 FAM76 protein Fib_alpha PF08702.10 KOO30344.1 - 0.16 12.2 5.9 0.16 12.1 3.6 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FUSC PF04632.12 KOO30344.1 - 0.23 10.0 7.7 0.25 9.8 7.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family AA_kinase PF00696.28 KOO30344.1 - 0.29 10.7 3.6 0.45 10.1 3.6 1.3 1 1 0 1 1 1 0 Amino acid kinase family Prefoldin_2 PF01920.20 KOO30344.1 - 0.42 10.6 13.2 16 5.5 0.8 3.4 2 1 1 3 3 3 0 Prefoldin subunit DUF641 PF04859.12 KOO30344.1 - 0.98 9.8 10.9 6.4 7.1 2.9 3.1 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) FlxA PF14282.6 KOO30344.1 - 1 9.4 8.8 11 6.0 0.7 3.2 1 1 2 3 3 3 0 FlxA-like protein UPF0242 PF06785.11 KOO30344.1 - 8.7 6.4 13.7 7.6 6.6 10.7 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 KOO30344.1 - 9.7 5.0 16.4 4.3 6.1 13.3 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein TIG PF01833.24 KOO30345.1 - 6.7e-62 205.6 0.3 3.3e-08 33.5 0.0 12.2 11 1 0 11 11 11 11 IPT/TIG domain Bact_lectin PF18483.1 KOO30345.1 - 0.016 15.3 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial lectin Peptidase_M24 PF00557.24 KOO30346.1 - 7.1e-46 156.5 0.0 1.3e-45 155.7 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 KOO30346.1 - 9.7e-38 129.8 0.0 4.5e-36 124.4 0.0 2.2 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Creatinase_N PF01321.18 KOO30346.1 - 1.6e-23 83.8 0.0 1.2e-19 71.2 0.0 2.8 3 0 0 3 3 3 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 KOO30346.1 - 2.4e-20 72.3 0.0 5.6e-20 71.2 0.0 1.7 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Phage_holin_3_3 PF16083.5 KOO30346.1 - 0.085 13.0 5.2 5.8 7.1 0.3 2.6 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III TIG PF01833.24 KOO30347.1 - 9.6e-71 233.9 15.8 4.8e-10 39.4 0.0 17.1 17 1 0 17 17 17 13 IPT/TIG domain TIG_plexin PF17960.1 KOO30347.1 - 1.1e-18 67.0 0.0 0.035 14.1 0.0 9.6 11 0 0 11 11 11 6 TIG domain MORN PF02493.20 KOO30348.1 - 1.9e-82 266.5 89.7 2.6e-06 27.0 2.4 15.5 16 0 0 16 16 16 14 MORN repeat Ion_trans PF00520.31 KOO30348.1 - 3.3e-24 85.4 5.1 4.9e-24 84.9 5.1 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO30348.1 - 2.3e-12 46.7 7.9 5.2e-12 45.6 7.9 1.6 1 0 0 1 1 1 1 Ion channel NQRA_SLBB PF11973.8 KOO30348.1 - 0.00051 20.6 0.1 5.2 7.8 0.0 4.9 5 1 1 6 6 6 1 NQRA C-terminal domain EF-hand_1 PF00036.32 KOO30348.1 - 0.0076 15.7 0.1 0.021 14.3 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO30348.1 - 0.037 13.5 0.4 0.037 13.5 0.4 2.1 2 0 0 2 2 2 0 EF hand SecD_SecF PF02355.16 KOO30348.1 - 0.041 13.3 1.6 0.071 12.5 1.6 1.3 1 0 0 1 1 1 0 Protein export membrane protein EF-hand_7 PF13499.6 KOO30348.1 - 0.06 13.8 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair PKD_channel PF08016.12 KOO30348.1 - 0.89 8.2 4.8 0.4 9.3 1.0 1.9 1 1 1 2 2 2 0 Polycystin cation channel BTB PF00651.31 KOO30349.1 - 2.8e-09 37.2 0.0 2.8e-07 30.8 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain Kelch_5 PF13854.6 KOO30349.1 - 1.5e-05 24.8 0.0 0.047 13.7 0.0 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 KOO30349.1 - 0.00063 19.9 2.2 0.46 10.8 0.0 3.3 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 KOO30349.1 - 0.0019 18.1 6.7 0.0069 16.4 0.0 3.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 KOO30349.1 - 0.0024 18.1 1.6 1.2 9.5 0.0 3.9 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KOO30349.1 - 0.0057 16.2 0.0 6.5 6.4 0.0 3.1 3 0 0 3 3 3 2 Kelch motif BACK PF07707.15 KOO30349.1 - 0.18 11.9 0.0 0.46 10.6 0.0 1.7 2 0 0 2 2 2 0 BTB And C-terminal Kelch PDZ_6 PF17820.1 KOO30351.1 - 0.0081 16.0 1.3 0.045 13.6 0.3 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO30351.1 - 0.0083 16.4 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF212 PF02681.14 KOO30351.1 - 0.43 10.7 5.1 0.95 9.6 5.1 1.5 1 0 0 1 1 1 0 Divergent PAP2 family Ribosomal_L14e PF01929.17 KOO30352.1 - 0.045 14.2 0.1 0.12 12.9 0.1 1.7 1 0 0 1 1 1 0 Ribosomal protein L14 MobA_MobL PF03389.15 KOO30353.1 - 0.067 12.9 0.2 0.12 12.1 0.2 1.6 2 1 0 2 2 2 0 MobA/MobL family Shufflon_N PF04917.12 KOO30354.1 - 0.12 11.8 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region CBS PF00571.28 KOO30355.1 - 1.8e-23 82.7 3.5 2.7e-09 37.3 0.1 4.2 4 0 0 4 4 4 4 CBS domain ATPgrasp_N PF18130.1 KOO30355.1 - 0.055 14.0 1.6 2.3 8.8 0.0 3.1 3 1 1 4 4 4 0 ATP-grasp N-terminal domain Peptidase_C69 PF03577.15 KOO30356.1 - 3.1e-54 184.4 0.1 1.2e-53 182.5 0.1 1.9 1 1 0 1 1 1 1 Peptidase family C69 Mtc PF03820.17 KOO30358.1 - 6e-29 101.1 0.0 6.6e-29 100.9 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier Asp PF00026.23 KOO30359.1 - 2.9e-25 89.3 0.0 3e-24 86.0 0.0 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO30359.1 - 1.7e-06 28.4 0.2 0.00044 20.5 0.2 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Hexapep PF00132.24 KOO30360.1 - 2e-18 65.3 15.2 9.5e-08 31.5 1.3 4.9 4 1 1 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KOO30360.1 - 0.0062 16.3 2.6 0.0062 16.3 2.6 4.1 3 1 1 4 4 4 3 Hexapeptide repeat of succinyl-transferase GBP PF02263.19 KOO30361.1 - 0.0016 17.8 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain EF-hand_6 PF13405.6 KOO30362.1 - 3e-26 89.1 0.2 7.1e-06 25.6 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO30362.1 - 1.4e-23 80.6 0.0 8.6e-05 21.8 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO30362.1 - 4.7e-21 75.0 0.1 2.8e-08 34.1 0.1 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO30362.1 - 4.2e-18 63.9 0.3 0.001 18.5 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO30362.1 - 5e-17 61.5 0.0 1.3e-06 28.2 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_10 PF14788.6 KOO30362.1 - 0.015 15.2 0.0 1.9 8.4 0.0 3.2 3 0 0 3 3 3 0 EF hand EF-hand_9 PF14658.6 KOO30362.1 - 0.015 15.6 0.0 0.68 10.3 0.0 2.7 2 1 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO30362.1 - 0.028 14.7 0.0 27 5.1 0.0 3.3 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO30362.1 - 0.18 11.8 0.2 3.4 7.7 0.0 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand FoP_duplication PF13865.6 KOO30363.1 - 7.8e-06 26.4 16.6 0.0014 19.2 9.8 2.2 1 1 1 2 2 2 2 C-terminal duplication domain of Friend of PRMT1 SelK_SelG PF10961.8 KOO30363.1 - 2.1 9.0 9.4 4.2 8.0 9.4 1.5 1 1 0 1 1 1 0 Selenoprotein SelK_SelG zf-PARP PF00645.18 KOO30364.1 - 5.2e-11 43.3 0.5 1.1e-07 32.6 0.1 2.9 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Sterol-sensing PF12349.8 KOO30365.1 - 6e-05 22.9 8.1 6.7e-05 22.8 6.7 1.8 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation DsrD PF08679.11 KOO30365.1 - 0.0011 19.2 0.0 0.21 11.9 0.0 2.3 2 0 0 2 2 2 2 Dissimilatory sulfite reductase D (DsrD) Patched PF02460.18 KOO30365.1 - 0.0021 16.3 0.6 0.0028 15.8 0.3 1.4 1 1 0 1 1 1 1 Patched family MMPL PF03176.15 KOO30365.1 - 0.26 10.2 7.8 0.45 9.4 7.8 1.3 1 0 0 1 1 1 0 MMPL family Patched PF02460.18 KOO30366.1 - 0.00017 19.8 16.4 0.00025 19.3 16.4 1.1 1 0 0 1 1 1 1 Patched family Sugar_tr PF00083.24 KOO30367.1 - 4.3e-17 62.1 9.0 6.2e-14 51.7 0.4 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Cyclin_N PF00134.23 KOO30368.1 - 1.4e-11 44.2 0.0 2.3e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 KOO30368.1 - 1.1e-08 35.7 0.0 1.7e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin SKG6 PF08693.10 KOO30369.1 - 0.0011 18.4 2.8 0.0026 17.1 2.8 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain PRIMA1 PF16101.5 KOO30369.1 - 0.19 11.8 15.3 1.6 8.8 7.4 2.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Adeno_E3_CR2 PF02439.15 KOO30369.1 - 2.5 7.9 6.5 0.22 11.3 1.2 2.0 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 Plavaka PF18759.1 KOO30370.1 - 2.3e-10 40.2 0.0 3.5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Plavaka transposase EF-hand_5 PF13202.6 KOO30372.1 - 2.6e-14 52.0 2.9 4.5e-05 22.8 0.3 3.7 3 0 0 3 3 3 3 EF hand EF-hand_1 PF00036.32 KOO30372.1 - 1.7e-13 49.1 3.0 0.0012 18.2 0.3 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO30372.1 - 1.7e-12 46.2 1.8 0.00082 19.1 0.2 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 KOO30372.1 - 2.4e-12 47.1 1.5 1.5e-07 31.8 0.3 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO30372.1 - 4.4e-08 32.9 2.1 0.26 11.2 0.0 4.0 3 1 1 4 4 4 3 EF-hand domain pair LRR_6 PF13516.6 KOO30372.1 - 7.4e-06 25.6 0.3 0.15 12.1 0.2 3.1 2 0 0 2 2 2 2 Leucine Rich repeat EF-hand_9 PF14658.6 KOO30372.1 - 0.067 13.5 0.1 5.9 7.3 0.0 3.6 4 0 0 4 4 4 0 EF-hand domain Myosin_head PF00063.21 KOO30373.1 - 1.3e-111 374.0 0.0 3e-89 300.0 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) AAA_16 PF13191.6 KOO30373.1 - 0.0029 18.0 4.6 0.014 15.8 4.6 2.3 1 1 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 KOO30373.1 - 0.0057 15.8 0.0 0.0089 15.1 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 KOO30373.1 - 0.034 14.4 0.0 0.066 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KOO30373.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 KOO30373.1 - 0.13 11.5 0.1 0.26 10.5 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin CbiA PF01656.23 KOO30373.1 - 0.14 12.2 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PARP PF00644.20 KOO30374.1 - 2.7e-14 53.2 0.0 6.3e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain EF-hand_7 PF13499.6 KOO30374.1 - 0.088 13.3 0.0 0.32 11.5 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair H2TH PF06831.14 KOO30378.1 - 2.5e-10 40.2 0.0 3.9e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.24 KOO30378.1 - 0.17 12.5 0.0 0.38 11.4 0.0 1.6 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase N-terminal domain Pkinase PF00069.25 KOO30379.1 - 1.2e-10 41.2 0.0 3.7e-10 39.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 KOO30379.1 - 0.0014 18.1 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO30379.1 - 0.0014 18.0 0.0 0.0029 17.0 0.0 1.4 2 0 0 2 2 2 1 Kinase-like 2OG-FeII_Oxy_3 PF13640.6 KOO30380.1 - 8.1e-14 52.3 0.0 1.3e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 KOO30380.1 - 0.32 10.1 0.0 0.36 9.9 0.0 1.1 1 0 0 1 1 1 0 Poxvirus C4/C10 protein Pentapeptide_4 PF13599.6 KOO30382.1 - 2.7e-26 91.5 0.0 3.8e-09 36.6 0.0 3.2 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.18 KOO30382.1 - 4.7e-05 23.3 5.2 1.5 8.7 0.1 5.5 2 1 2 6 6 6 2 Ribosomal protein L13e Ntox33 PF15533.6 KOO30382.1 - 0.0029 18.1 0.0 24 5.5 0.1 4.8 3 1 1 5 5 5 0 Bacterial toxin 33 AAA_lid_3 PF17862.1 KOO30382.1 - 0.0035 17.1 3.3 7.4 6.5 0.1 5.5 6 1 0 6 6 6 1 AAA+ lid domain Pentapeptide PF00805.22 KOO30382.1 - 0.069 12.8 0.6 3.3 7.4 0.1 2.9 2 1 0 2 2 2 0 Pentapeptide repeats (8 copies) LytR_C PF13399.6 KOO30382.1 - 0.086 13.8 4.3 29 5.7 1.3 4.7 1 1 1 2 2 2 0 LytR cell envelope-related transcriptional attenuator MerR-DNA-bind PF09278.11 KOO30382.1 - 0.2 12.2 3.8 28 5.3 0.0 4.7 4 2 0 4 4 4 0 MerR, DNA binding N_methyl PF07963.12 KOO30382.1 - 0.7 9.6 5.4 4.5 7.0 0.0 4.1 4 0 0 4 4 4 0 Prokaryotic N-terminal methylation motif Clp_N PF02861.20 KOO30382.1 - 0.81 9.9 3.4 40 4.4 0.0 4.0 4 0 0 4 4 4 0 Clp amino terminal domain, pathogenicity island component Porin_3 PF01459.22 KOO30383.1 - 3.2e-48 164.5 0.2 3.7e-48 164.3 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin OprB PF04966.12 KOO30383.1 - 0.014 14.8 3.1 0.066 12.6 2.1 2.0 2 0 0 2 2 2 0 Carbohydrate-selective porin, OprB family DAGK_cat PF00781.24 KOO30384.1 - 3.4e-20 71.9 0.0 5.2e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain PT PF04886.12 KOO30384.1 - 0.0088 15.6 10.4 0.017 14.6 10.4 1.4 1 0 0 1 1 1 1 PT repeat Peptidase_M8 PF01457.16 KOO30385.1 - 1.8e-18 66.6 0.2 4e-18 65.4 0.0 1.6 2 0 0 2 2 2 1 Leishmanolysin Astacin PF01400.24 KOO30385.1 - 0.087 12.4 0.2 0.19 11.3 0.2 1.4 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Tail_VII PF17091.5 KOO30385.1 - 0.58 10.1 2.5 1.9 8.4 2.5 1.9 1 0 0 1 1 1 0 Inovirus G7P protein Bax1-I PF01027.20 KOO30385.1 - 3.5 7.4 15.1 1.3 8.8 11.6 1.9 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 Reprolysin_3 PF13582.6 KOO30385.1 - 5.2 7.6 5.3 6.8 7.2 0.3 2.6 3 0 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like IMS PF00817.20 KOO30386.1 - 7e-36 123.5 0.0 1.3e-35 122.6 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_HHH PF11798.8 KOO30386.1 - 2.8e-07 30.5 0.0 6.8e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif UCMA PF17085.5 KOO30386.1 - 0.011 15.7 1.1 0.019 15.0 1.1 1.3 1 0 0 1 1 1 0 Unique cartilage matrix associated protein Peptidase_C1 PF00112.23 KOO30387.1 - 3.4e-71 239.8 1.5 4.5e-71 239.4 1.5 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KOO30387.1 - 9.2e-12 45.2 0.1 1.5e-11 44.5 0.1 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KOO30387.1 - 7.7e-07 28.2 2.7 0.0002 20.3 0.2 3.2 1 1 1 3 3 3 3 Peptidase C1-like family Rad60-SLD PF11976.8 KOO30388.1 - 1e-24 86.1 0.1 1.2e-24 85.9 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOO30388.1 - 6.3e-13 48.3 0.0 7.5e-13 48.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family zf-CCHC PF00098.23 KOO30389.1 - 2.8e-06 27.2 13.7 0.0002 21.3 0.9 2.2 2 0 0 2 2 2 2 Zinc knuckle Rhodanese_C PF12368.8 KOO30389.1 - 0.0031 17.9 2.0 0.0044 17.4 2.0 1.2 1 0 0 1 1 1 1 Rhodanase C-terminal zf-CCHC_4 PF14392.6 KOO30389.1 - 0.0032 17.1 7.8 0.027 14.2 0.8 2.2 2 0 0 2 2 2 2 Zinc knuckle zf-C2H2_10 PF16588.5 KOO30389.1 - 0.015 15.0 16.2 0.046 13.5 5.4 2.2 2 0 0 2 2 2 0 C2H2 zinc-finger zf-CCHC_2 PF13696.6 KOO30389.1 - 0.016 15.1 13.3 0.58 10.0 0.6 2.2 2 0 0 2 2 2 0 Zinc knuckle PHD_4 PF16866.5 KOO30389.1 - 0.023 14.8 3.1 0.036 14.2 3.1 1.2 1 0 0 1 1 1 0 PHD-finger Cys_rich_CPXG PF14255.6 KOO30389.1 - 0.023 14.6 0.6 6.2 6.8 0.0 2.3 2 0 0 2 2 2 0 Cysteine-rich CPXCG zf-CCHC_3 PF13917.6 KOO30389.1 - 0.19 11.7 0.1 0.19 11.7 0.1 2.3 1 1 1 2 2 2 0 Zinc knuckle Lar_restr_allev PF14354.6 KOO30389.1 - 0.22 11.9 3.8 0.4 11.1 3.8 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar Mre11_DNA_bind PF04152.14 KOO30390.1 - 2.2e-18 67.1 0.1 2.6e-17 63.6 0.0 2.1 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain TPH PF13868.6 KOO30391.1 - 0.00011 20.9 110.9 0.00014 20.6 110.1 1.6 1 1 0 1 1 1 1 Trichohyalin-plectin-homology domain SET PF00856.28 KOO30392.1 - 1.6e-08 35.1 0.0 3.6e-08 34.0 0.0 1.7 1 1 0 1 1 1 1 SET domain HalOD2 PF18547.1 KOO30392.1 - 0.011 15.6 7.1 0.011 15.6 7.1 2.3 2 0 0 2 2 2 0 Halobacterial output domain 2 rve PF00665.26 KOO30393.1 - 1.3e-06 28.6 0.0 3.4e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Glyco_transf_8 PF01501.20 KOO30394.1 - 3.5e-14 53.0 0.0 1.2e-13 51.2 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 KOO30394.1 - 0.0057 16.1 0.1 0.0094 15.3 0.1 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative MRP-L47 PF06984.13 KOO30394.1 - 0.0075 16.4 0.4 0.014 15.5 0.4 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) MT PF12777.7 KOO30395.1 - 4.3e-05 22.7 0.0 6.1e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor PUB PF09409.10 KOO30396.1 - 6.4e-12 45.3 0.0 9.5e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 PUB domain ClpS PF02617.17 KOO30397.1 - 1e-08 34.9 0.0 1.6e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS PUMA PF15826.5 KOO30397.1 - 0.0026 18.0 0.2 0.003 17.7 0.2 1.2 1 0 0 1 1 1 1 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis PMSR PF01625.21 KOO30399.1 - 2.5e-09 37.5 0.1 4.3e-09 36.7 0.1 1.4 1 1 0 1 1 1 1 Peptide methionine sulfoxide reductase WD40 PF00400.32 KOO30400.1 - 3.3e-39 132.2 14.8 1.1e-07 32.4 0.0 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO30400.1 - 5.4e-13 49.1 0.4 0.0025 18.0 0.0 4.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO30400.1 - 2.6e-10 39.8 2.3 0.046 12.7 0.0 4.2 2 1 2 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_16 PF13191.6 KOO30400.1 - 2e-08 34.8 0.0 9.2e-08 32.6 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 KOO30400.1 - 7.5e-08 32.5 0.0 1.7e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain PD40 PF07676.12 KOO30400.1 - 1.6e-07 31.1 0.0 4.6 7.3 0.0 4.6 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat APAF1_C PF17908.1 KOO30400.1 - 2.1e-05 24.6 0.0 6.9e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 APAF-1 helical domain Frtz PF11768.8 KOO30400.1 - 0.0041 15.5 0.0 2.6 6.3 0.0 3.0 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO30400.1 - 0.018 14.4 0.7 16 4.7 0.0 3.5 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal KAP_NTPase PF07693.14 KOO30400.1 - 0.039 13.2 0.0 0.27 10.4 0.0 2.0 2 0 0 2 2 2 0 KAP family P-loop domain ELL PF10390.9 KOO30401.1 - 0.095 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL EF-hand_1 PF00036.32 KOO30402.1 - 2.5e-11 42.3 0.0 2.2e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO30402.1 - 8.8e-11 40.8 0.1 1.8e-05 24.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO30402.1 - 6.1e-10 38.2 0.1 0.0003 20.5 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO30402.1 - 8.4e-08 32.6 0.1 6.6e-07 29.7 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO30402.1 - 0.00042 20.1 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair LRR_6 PF13516.6 KOO30402.1 - 0.0056 16.6 0.1 0.12 12.5 0.0 3.1 2 0 0 2 2 2 1 Leucine Rich repeat LRR_8 PF13855.6 KOO30402.1 - 0.019 14.7 0.9 0.19 11.5 0.9 2.4 1 1 0 1 1 1 0 Leucine rich repeat LRR_4 PF12799.7 KOO30402.1 - 0.14 12.6 2.2 0.64 10.5 2.1 2.2 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) KH_1 PF00013.29 KOO30403.1 - 9.4e-20 70.2 0.2 1.5e-07 31.2 0.0 3.6 4 0 0 4 4 4 3 KH domain KH_2 PF07650.17 KOO30403.1 - 0.00035 20.3 0.2 0.57 10.0 0.1 2.5 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 KOO30403.1 - 0.00096 19.0 0.1 0.32 10.9 0.0 2.5 2 0 0 2 2 2 2 KH domain CAP_N PF01213.19 KOO30403.1 - 4.3 6.7 7.4 8.5 5.8 7.4 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Kringle PF00051.18 KOO30404.1 - 9.2e-30 102.8 6.9 1.6e-20 73.2 0.6 2.7 2 0 0 2 2 2 2 Kringle domain Notch PF00066.17 KOO30404.1 - 2.7e-27 94.9 90.0 3e-06 27.6 10.6 5.6 5 0 0 5 5 5 5 LNR domain Sulfotransfer_3 PF13469.6 KOO30404.1 - 0.00015 22.2 0.0 0.00036 21.0 0.0 1.6 1 0 0 1 1 1 1 Sulfotransferase family Glyco_transf_8 PF01501.20 KOO30404.1 - 0.31 10.6 0.0 0.54 9.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 8 Ion_trans PF00520.31 KOO30405.1 - 1.8e-205 679.1 61.5 1.1e-57 195.0 0.1 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO30405.1 - 2.6e-10 39.6 76.6 2.1e-07 30.0 1.6 8.4 7 2 2 9 9 9 8 Polycystin cation channel GPHH PF16905.5 KOO30405.1 - 1.9e-07 30.7 0.0 4.3e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Kinesin PF00225.23 KOO30406.1 - 1.7e-20 73.2 0.0 1.9e-19 69.8 0.0 2.2 1 1 0 1 1 1 1 Kinesin motor domain TPR_12 PF13424.6 KOO30406.1 - 1.9e-17 63.3 18.1 2.2e-09 37.5 7.1 3.4 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO30406.1 - 3.3e-08 33.1 9.7 0.00025 20.8 2.3 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat Microtub_bd PF16796.5 KOO30406.1 - 1e-06 28.7 0.0 1.7e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding TPR_2 PF07719.17 KOO30406.1 - 0.0002 21.2 6.6 0.44 10.8 0.9 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO30406.1 - 0.0011 18.7 1.0 0.4 10.6 0.7 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_22 PF13401.6 KOO30406.1 - 0.049 13.9 1.1 0.16 12.2 0.3 2.3 3 0 0 3 3 3 0 AAA domain TPR_7 PF13176.6 KOO30406.1 - 0.24 11.5 6.5 15 5.9 0.5 4.2 3 1 0 3 3 3 0 Tetratricopeptide repeat Alk_phosphatase PF00245.20 KOO30407.1 - 3e-91 306.4 0.0 1.7e-81 274.3 0.0 2.3 2 0 0 2 2 2 2 Alkaline phosphatase Metalloenzyme PF01676.18 KOO30407.1 - 5.5e-05 22.7 0.0 0.00019 20.9 0.0 1.9 1 1 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 KOO30407.1 - 0.00043 19.8 0.0 0.00059 19.3 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Peptidase_A25 PF03418.14 KOO30407.1 - 0.069 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Germination protease Laminin_G_3 PF13385.6 KOO30410.1 - 3.5e-07 30.5 0.0 4.2e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EXS PF03124.14 KOO30411.1 - 4.1e-69 233.4 17.1 5.3e-69 233.1 17.1 1.1 1 0 0 1 1 1 1 EXS family WW PF00397.26 KOO30412.1 - 8.3e-06 25.8 5.3 1.2e-05 25.3 5.3 1.2 1 0 0 1 1 1 1 WW domain Frigida PF07899.11 KOO30412.1 - 0.0034 16.7 0.1 0.0045 16.3 0.1 1.1 1 0 0 1 1 1 1 Frigida-like protein UQ_con PF00179.26 KOO30413.1 - 2.8e-41 140.4 0.0 3.1e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO30413.1 - 3.5e-05 23.5 0.0 4.4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 KOO30413.1 - 0.037 13.7 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 KOO30413.1 - 0.22 11.8 0.4 0.33 11.3 0.4 1.4 1 1 0 1 1 1 0 RWD domain DUF5527 PF17665.1 KOO30414.1 - 0.16 11.5 0.4 0.25 10.9 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5527) HSP70 PF00012.20 KOO30416.1 - 4.1e-138 461.2 0.9 4.6e-138 461.1 0.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOO30416.1 - 2.5e-11 43.0 0.0 5.9e-10 38.5 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 KOO30416.1 - 0.048 12.9 0.2 0.086 12.1 0.1 1.5 1 1 1 2 2 2 0 Hydantoinase/oxoprolinase StbA PF06406.11 KOO30416.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 StbA protein DUF4381 PF14316.6 KOO30418.1 - 9.6e-07 29.1 2.9 1.2e-06 28.9 2.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) DUF2681 PF10883.8 KOO30418.1 - 0.0002 21.7 0.8 0.00032 21.0 0.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) T2SSM PF04612.12 KOO30418.1 - 0.00045 20.3 1.9 0.00067 19.8 1.9 1.3 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein M HemX PF04375.14 KOO30418.1 - 0.00083 18.7 0.1 0.00092 18.6 0.1 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase Holin_BhlA PF10960.8 KOO30418.1 - 0.0023 17.9 0.2 0.0031 17.4 0.2 1.2 1 0 0 1 1 1 1 BhlA holin family SKG6 PF08693.10 KOO30418.1 - 0.012 15.0 0.1 0.017 14.5 0.1 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain YajC PF02699.15 KOO30418.1 - 0.012 15.4 0.1 0.021 14.7 0.1 1.3 1 0 0 1 1 1 0 Preprotein translocase subunit MFS_1 PF07690.16 KOO30418.1 - 0.032 13.1 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily OPA3 PF07047.12 KOO30418.1 - 0.033 14.0 0.1 0.055 13.2 0.1 1.3 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) DUF4131 PF13567.6 KOO30418.1 - 0.038 13.6 0.1 0.05 13.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Helo_like_N PF17111.5 KOO30418.1 - 0.088 12.2 0.2 0.1 11.9 0.2 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins MukB_hinge PF16330.5 KOO30418.1 - 0.1 12.3 0.2 0.14 11.8 0.2 1.2 1 0 0 1 1 1 0 MukB hinge domain Vpu PF00558.19 KOO30418.1 - 0.11 12.3 0.2 0.18 11.6 0.2 1.4 1 0 0 1 1 1 0 Vpu protein EphA2_TM PF14575.6 KOO30418.1 - 0.15 13.0 0.0 0.17 12.8 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain BT1 PF03092.16 KOO30418.1 - 0.2 9.9 0.0 0.2 9.9 0.0 1.0 1 0 0 1 1 1 0 BT1 family LapA_dom PF06305.11 KOO30418.1 - 0.73 9.7 7.6 1.6 8.6 7.6 1.6 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Stevor PF17410.2 KOO30418.1 - 2.8 7.4 4.1 11 5.5 2.6 2.1 1 1 1 2 2 2 0 Subtelomeric Variable Open Reading frame TPR_1 PF00515.28 KOO30419.1 - 2.5e-25 87.2 14.3 2.6e-06 27.0 0.0 10.1 11 1 0 11 11 11 5 Tetratricopeptide repeat TPR_2 PF07719.17 KOO30419.1 - 3.8e-22 76.6 16.3 6.3e-06 25.9 0.0 9.0 10 0 0 10 10 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30419.1 - 4.7e-21 73.2 1.6 0.0025 17.9 0.0 10.0 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30419.1 - 4.2e-16 58.3 18.1 0.0024 18.5 0.4 8.4 6 2 3 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO30419.1 - 7.5e-15 55.2 3.4 0.00067 20.1 0.2 5.1 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO30419.1 - 1.3e-14 54.5 9.6 1.8e-05 25.3 2.3 5.2 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOO30419.1 - 1.6e-13 50.1 5.3 5.8e-06 25.9 0.2 7.2 7 1 1 8 8 7 3 TPR repeat TPR_6 PF13174.6 KOO30419.1 - 5.1e-11 42.5 3.5 0.099 13.3 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO30419.1 - 1.8e-10 40.1 10.4 0.00057 19.7 0.1 6.9 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_21 PF09976.9 KOO30419.1 - 1.4e-09 38.0 4.6 0.0058 16.4 0.1 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 KOO30419.1 - 1.5e-09 38.0 21.3 0.058 13.7 1.9 7.5 5 2 1 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO30419.1 - 3.7e-09 36.3 6.8 0.27 11.7 0.1 7.6 10 0 0 10 10 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO30419.1 - 2.4e-08 34.0 17.0 0.0015 18.6 1.8 6.3 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_15 PF13429.6 KOO30419.1 - 3.9e-08 32.8 5.7 0.062 12.5 0.0 4.3 4 1 1 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO30419.1 - 2.2e-05 24.6 6.8 8.2e-05 22.8 0.2 3.5 4 0 0 4 4 3 1 Anaphase-promoting complex, cyclosome, subunit 3 FAT PF02259.23 KOO30419.1 - 0.0015 17.8 0.1 1.9 7.6 0.0 3.0 2 1 0 2 2 2 2 FAT domain TPR_MalT PF17874.1 KOO30419.1 - 0.0023 17.4 4.2 0.58 9.5 0.1 3.6 3 1 1 4 4 4 2 MalT-like TPR region TPR_10 PF13374.6 KOO30419.1 - 0.0052 16.6 5.6 1.3 9.0 0.2 4.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 KOO30419.1 - 0.007 16.7 3.9 2.3 8.6 0.1 3.2 3 1 1 4 4 3 2 Tetratricopeptide repeat Arg_decarb_HB PF17810.1 KOO30419.1 - 0.028 14.7 2.6 5.3 7.4 0.1 3.7 4 0 0 4 4 4 0 Arginine decarboxylase helical bundle domain SNAP PF14938.6 KOO30419.1 - 0.039 13.4 5.0 3.6 6.9 0.0 3.5 3 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP TOM20_plant PF06552.12 KOO30419.1 - 0.07 12.9 0.4 12 5.6 0.0 3.7 3 1 0 4 4 3 0 Plant specific mitochondrial import receptor subunit TOM20 BTAD PF03704.17 KOO30419.1 - 0.072 13.5 3.0 0.11 13.0 0.7 2.5 2 0 0 2 2 2 0 Bacterial transcriptional activator domain ChAPs PF09295.10 KOO30419.1 - 0.073 12.1 0.1 0.19 10.7 0.0 1.7 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) Coatomer_WDAD PF04053.14 KOO30419.1 - 0.17 10.9 0.7 0.37 9.8 0.0 1.7 2 0 0 2 2 2 0 Coatomer WD associated region TRM PF02005.16 KOO30421.1 - 7.4e-57 193.2 0.0 9e-57 192.9 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase DUF2067 PF09840.9 KOO30421.1 - 0.15 11.7 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) DUF1298 PF06974.13 KOO30422.1 - 8.7e-27 93.8 0.0 1.7e-26 92.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) WES_acyltransf PF03007.16 KOO30422.1 - 3.8e-12 46.5 1.2 3.5e-11 43.4 0.1 2.8 3 0 0 3 3 3 1 Wax ester synthase-like Acyl-CoA acyltransferase domain Condensation PF00668.20 KOO30422.1 - 0.0011 17.7 0.0 0.053 12.2 0.0 2.1 2 0 0 2 2 2 2 Condensation domain Ly-6_related PF06579.12 KOO30423.1 - 0.14 12.4 0.1 0.22 11.8 0.1 1.3 1 0 0 1 1 1 0 Caenorhabditis elegans ly-6-related protein HEAT_2 PF13646.6 KOO30425.1 - 0.0012 19.2 0.9 0.0012 19.2 0.9 3.1 3 1 1 4 4 4 1 HEAT repeats HEAT PF02985.22 KOO30425.1 - 0.016 15.4 5.9 0.15 12.4 0.1 3.6 3 0 0 3 3 3 0 HEAT repeat CCDC92 PF14916.6 KOO30427.1 - 0.097 12.4 3.9 0.18 11.6 0.4 2.7 2 0 0 2 2 2 0 Coiled-coil domain of unknown function SpoU_methylase PF00588.19 KOO30427.1 - 0.64 10.2 4.9 0.13 12.4 0.8 2.0 2 0 0 2 2 2 0 SpoU rRNA Methylase family Methyltransf_24 PF13578.6 KOO30428.1 - 1.3e-06 29.4 0.0 1.7e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain zf-C3HC4_3 PF13920.6 KOO30429.1 - 8.9e-12 44.7 8.5 1.8e-11 43.7 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO30429.1 - 1.1e-05 25.2 8.6 2.1e-05 24.3 8.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOO30429.1 - 2.5e-05 24.5 8.6 5.4e-05 23.4 8.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KOO30429.1 - 0.038 14.0 7.8 0.075 13.0 7.8 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOO30429.1 - 0.046 13.6 9.4 0.1 12.5 9.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO30429.1 - 0.06 13.4 5.3 0.11 12.5 5.3 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KOO30429.1 - 0.33 11.1 8.7 0.61 10.3 8.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PhyH PF05721.13 KOO30432.1 - 2.1e-14 54.3 0.0 7.6e-14 52.5 0.0 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Helicase_C PF00271.31 KOO30433.1 - 6.3e-15 55.5 0.0 1.1e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KOO30433.1 - 1.2e-12 47.3 0.0 7.5e-06 24.9 0.0 2.9 3 0 0 3 3 3 2 SNF2 family N-terminal domain ERCC3_RAD25_C PF16203.5 KOO30433.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CS PF04969.16 KOO30434.1 - 0.00056 20.9 0.0 0.0013 19.7 0.0 1.7 1 1 0 1 1 1 1 CS domain BAF1_ABF1 PF04684.13 KOO30434.1 - 0.4 9.7 11.1 0.52 9.3 11.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor EII-Sor PF03609.14 KOO30435.1 - 0.0036 16.7 4.0 0.0057 16.1 4.0 1.3 1 0 0 1 1 1 1 PTS system sorbose-specific iic component Bact_lectin PF18483.1 KOO30436.1 - 0.00042 20.4 0.0 0.0089 16.1 0.0 2.3 1 1 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 KOO30436.1 - 0.14 11.7 0.0 0.44 10.0 0.0 1.8 2 0 0 2 2 2 0 Legume lectin domain Inositol_P PF00459.25 KOO30438.1 - 5.6e-33 114.6 0.0 1e-32 113.8 0.0 1.3 1 1 0 1 1 1 1 Inositol monophosphatase family Ion_trans_2 PF07885.16 KOO30439.1 - 6.7e-06 26.0 15.9 6.4e-05 22.8 4.4 2.5 2 0 0 2 2 2 2 Ion channel EI24 PF07264.11 KOO30439.1 - 0.12 12.7 2.7 0.53 10.5 2.8 2.0 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) PhoLip_ATPase_C PF16212.5 KOO30439.1 - 3.9 7.1 7.7 3.5 7.3 3.0 2.1 2 0 0 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal DUF4191 PF13829.6 KOO30439.1 - 6.3 6.1 5.6 62 2.8 3.0 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4191) Ribosomal_S5_C PF03719.15 KOO30441.1 - 4.4e-25 86.9 0.2 1.5e-24 85.3 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 KOO30441.1 - 1.6e-23 82.5 0.1 2.7e-23 81.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain DUF1635 PF07795.11 KOO30442.1 - 0.07 13.0 2.8 0.1 12.4 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) IKKbetaNEMObind PF12179.8 KOO30442.1 - 0.15 12.1 0.8 0.28 11.3 0.8 1.4 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain Presenilin PF01080.17 KOO30442.1 - 2.6 6.7 3.6 2.9 6.5 3.6 1.1 1 0 0 1 1 1 0 Presenilin ADK PF00406.22 KOO30443.1 - 0.00054 20.1 0.0 0.00059 20.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase Na_H_antiporter PF03553.14 KOO30444.1 - 4.1e-40 137.9 7.2 4.1e-40 137.9 7.2 2.1 1 1 1 2 2 2 2 Na+/H+ antiporter family DnaJ PF00226.31 KOO30445.1 - 3.6e-21 75.1 0.6 6.3e-21 74.3 0.2 1.6 2 0 0 2 2 2 1 DnaJ domain TPR_2 PF07719.17 KOO30445.1 - 9.1e-05 22.3 4.3 0.26 11.5 0.1 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO30445.1 - 0.00034 20.3 0.2 0.16 11.9 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30445.1 - 0.039 14.2 0.1 2.2 8.7 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SecA_DEAD PF07517.14 KOO30446.1 - 4.7e-06 26.1 2.0 1.2e-05 24.7 0.0 2.9 3 0 0 3 3 3 1 SecA DEAD-like domain PLU-1 PF08429.11 KOO30446.1 - 0.00011 21.5 26.6 0.0026 17.0 0.4 5.3 4 1 1 5 5 5 4 PLU-1-like protein ResIII PF04851.15 KOO30446.1 - 0.045 13.7 0.0 0.19 11.8 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit TauE PF01925.19 KOO30448.1 - 3.2e-23 82.6 38.7 1.8e-12 47.5 3.8 2.2 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE DUF3169 PF11368.8 KOO30448.1 - 0.0095 15.5 2.0 0.23 10.9 0.0 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF3169) VitK2_biosynth PF02621.14 KOO30448.1 - 0.027 14.0 0.5 0.048 13.2 0.5 1.3 1 0 0 1 1 1 0 Menaquinone biosynthesis RRM_1 PF00076.22 KOO30449.1 - 0.00063 19.5 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.12 KOO30449.1 - 0.012 15.3 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Calcipressin LRR_8 PF13855.6 KOO30450.1 - 1.3e-06 28.0 2.8 1.4e-06 27.9 0.2 2.3 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 KOO30450.1 - 9.9e-06 25.8 2.0 0.00087 19.6 0.1 2.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) DUF4795 PF16043.5 KOO30450.1 - 0.26 10.9 4.4 0.47 10.0 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) TRP PF06011.12 KOO30450.1 - 0.39 9.4 3.0 0.27 9.9 0.6 1.8 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel DUF5362 PF17319.2 KOO30450.1 - 2.6 7.9 6.0 0.44 10.4 1.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5362) DUF4083 PF13314.6 KOO30450.1 - 3.3 7.7 4.3 34 4.5 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) EF-hand_1 PF00036.32 KOO30452.1 - 1.4e-13 49.3 7.2 3.5e-05 23.1 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO30452.1 - 2.9e-13 48.6 4.1 0.0039 17.0 0.0 3.8 4 0 0 4 4 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO30452.1 - 5.7e-09 36.3 11.1 0.012 16.0 0.3 4.4 3 2 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO30452.1 - 5.2e-07 29.4 1.2 0.0014 18.5 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO30452.1 - 1e-06 28.0 11.7 0.013 15.0 0.2 4.2 5 0 0 5 5 5 2 EF hand Caleosin PF05042.13 KOO30452.1 - 0.0028 17.6 1.0 2.2 8.2 0.1 3.2 3 1 1 4 4 4 1 Caleosin related protein PIG-L PF02585.17 KOO30452.1 - 0.0091 16.6 0.3 5.7 7.6 0.1 2.6 2 2 0 2 2 2 1 GlcNAc-PI de-N-acetylase SesA PF17107.5 KOO30452.1 - 0.01 16.0 5.8 0.35 11.1 0.8 2.7 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases KxDL PF10241.9 KOO30452.1 - 0.011 16.0 5.1 1.1 9.6 0.4 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF948 PF06103.11 KOO30452.1 - 0.053 13.8 4.6 0.26 11.6 0.2 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) LMBR1 PF04791.16 KOO30452.1 - 0.056 12.3 1.2 0.077 11.9 1.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TSNAXIP1_N PF15739.5 KOO30452.1 - 0.16 12.3 7.9 1.3 9.4 2.3 2.6 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus RGS-like PF09128.11 KOO30452.1 - 0.18 11.5 5.8 0.23 11.1 0.3 2.4 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain ACP_PD PF04336.12 KOO30452.1 - 0.23 11.9 2.2 1.7 9.1 0.1 2.4 2 0 0 2 2 2 0 Acyl carrier protein phosphodiesterase TMPIT PF07851.13 KOO30452.1 - 0.44 9.7 8.1 0.85 8.8 0.2 2.1 2 0 0 2 2 2 0 TMPIT-like protein p25-alpha PF05517.12 KOO30452.1 - 1.1 9.4 5.9 1.4 9.0 0.5 2.6 2 1 0 2 2 2 0 p25-alpha Nup88 PF10168.9 KOO30452.1 - 2.7 5.7 15.0 0.32 8.8 1.8 2.1 2 0 0 2 2 2 0 Nuclear pore component TnpV PF14198.6 KOO30452.1 - 3.4 7.7 11.2 2.1 8.4 6.0 2.2 2 0 0 2 2 2 0 Transposon-encoded protein TnpV ALMT PF11744.8 KOO30452.1 - 3.9 6.2 9.1 6.4 5.5 0.6 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF16 PF01519.16 KOO30452.1 - 6.6 7.3 11.1 9.5 6.8 1.2 2.6 2 1 1 3 3 3 0 Protein of unknown function DUF16 EF-hand_1 PF00036.32 KOO30454.1 - 8.4e-10 37.5 0.9 0.00067 19.0 0.1 2.3 2 0 0 2 2 2 2 EF hand FAST_1 PF06743.15 KOO30454.1 - 8.6e-10 38.4 2.5 0.005 16.8 0.1 4.2 2 1 4 6 6 6 4 FAST kinase-like protein, subdomain 1 EF-hand_7 PF13499.6 KOO30454.1 - 2e-08 34.6 0.2 3.3e-08 33.8 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO30454.1 - 6.7e-08 31.9 0.0 0.00014 21.5 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO30454.1 - 8.3e-07 28.8 1.8 0.0019 18.0 0.2 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO30454.1 - 0.00067 19.0 1.4 0.003 17.0 0.4 2.2 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 KOO30454.1 - 0.0023 18.2 0.1 0.0063 16.8 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain HEAT_PBS PF03130.16 KOO30454.1 - 0.44 11.4 3.7 9.7 7.2 0.8 3.6 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat Pkinase PF00069.25 KOO30455.1 - 5e-65 219.5 0.0 6.1e-65 219.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30455.1 - 6.8e-32 110.8 0.0 9.1e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO30455.1 - 0.0018 17.7 0.0 0.0049 16.2 0.0 1.6 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOO30455.1 - 0.0061 15.5 1.3 0.011 14.7 1.3 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOO30455.1 - 0.043 13.2 1.0 0.081 12.3 1.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GMC_oxred_N PF00732.19 KOO30457.1 - 1.1e-51 176.0 0.0 1.8e-51 175.3 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOO30457.1 - 2.4e-31 109.2 0.0 4e-31 108.5 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 KOO30457.1 - 0.00066 19.9 0.5 0.0021 18.3 0.5 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO30457.1 - 0.0039 16.8 6.3 0.011 15.3 3.2 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOO30457.1 - 0.031 13.4 6.1 0.13 11.3 3.0 2.1 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 KOO30457.1 - 0.052 12.3 0.3 0.092 11.4 0.3 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_2 PF07992.14 KOO30457.1 - 0.071 12.3 1.1 0.15 11.3 1.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO30457.1 - 0.19 10.9 1.4 0.38 10.0 1.4 1.4 1 0 0 1 1 1 0 FAD binding domain HATPase_c_3 PF13589.6 KOO30458.1 - 2e-08 34.1 0.0 4.8e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Tudor_3 PF18115.1 KOO30458.1 - 9.1e-07 28.6 0.3 1e-05 25.2 0.0 2.4 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain TUDOR_5 PF18359.1 KOO30458.1 - 0.00047 19.8 0.1 0.0012 18.5 0.1 1.6 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 Morc6_S5 PF17942.1 KOO30458.1 - 0.004 17.2 0.0 3.8 7.6 0.0 3.1 2 1 0 2 2 2 1 Morc6 ribosomal protein S5 domain 2-like HATPase_c PF02518.26 KOO30458.1 - 0.021 15.3 0.0 0.052 14.1 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1325 PF07039.11 KOO30458.1 - 0.034 14.2 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 SGF29 tudor-like domain Agenet PF05641.12 KOO30458.1 - 0.051 14.0 0.0 0.24 11.9 0.0 2.1 2 0 0 2 2 2 0 Agenet domain Sporozoite_P67 PF05642.11 KOO30458.1 - 0.15 10.1 0.9 0.33 9.0 0.9 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ion_trans PF00520.31 KOO30459.1 - 5e-27 94.7 6.9 7.6e-27 94.1 6.9 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO30459.1 - 5.9e-12 45.4 1.0 5.9e-12 45.4 1.0 2.9 4 0 0 4 4 4 1 Ion channel cNMP_binding PF00027.29 KOO30459.1 - 2.4e-05 24.3 0.0 0.00019 21.4 0.0 2.3 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_7 PF13499.6 KOO30460.1 - 9.5e-12 45.2 0.1 1.7e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO30460.1 - 3.3e-11 41.9 1.9 0.00017 20.9 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO30460.1 - 2.8e-10 39.9 0.1 6.8e-10 38.6 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO30460.1 - 3.2e-10 39.1 0.9 5.6e-06 25.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO30460.1 - 5.3e-06 25.7 3.4 0.0021 17.4 0.1 2.8 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.7 KOO30460.1 - 0.018 15.0 0.0 3.7 7.6 0.0 3.0 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO30460.1 - 0.11 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Bac_surface_Ag PF01103.23 KOO30461.1 - 4.8e-10 39.4 2.4 4.9e-08 32.8 1.0 2.1 2 0 0 2 2 2 2 Surface antigen POTRA_2 PF08479.11 KOO30461.1 - 0.0022 17.8 0.1 0.0098 15.7 0.1 2.1 1 1 0 1 1 1 1 POTRA domain, ShlB-type POTRA PF07244.15 KOO30461.1 - 0.18 12.4 0.1 0.93 10.1 0.1 2.0 1 1 0 1 1 1 0 Surface antigen variable number repeat ABC_tran PF00005.27 KOO30462.1 - 9e-35 120.2 0.0 1.5e-34 119.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOO30462.1 - 9.8e-25 87.7 7.4 1.8e-24 86.9 7.4 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region C1_2 PF03107.16 KOO30462.1 - 0.00068 19.9 11.2 0.0013 19.0 11.2 1.5 1 0 0 1 1 1 1 C1 domain SMC_N PF02463.19 KOO30462.1 - 0.002 17.6 0.0 0.012 15.0 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO30462.1 - 0.0077 16.6 0.1 0.017 15.5 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain SbcCD_C PF13558.6 KOO30462.1 - 0.01 16.1 3.1 0.06 13.6 1.3 2.7 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 KOO30462.1 - 0.039 14.2 0.3 0.22 11.8 0.3 2.1 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KOO30462.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 KOO30462.1 - 0.073 12.6 0.0 0.56 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOO30462.1 - 0.099 12.4 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain zf-B_box PF00643.24 KOO30462.1 - 1.5 9.0 8.3 4.6 7.5 8.3 1.9 1 0 0 1 1 1 0 B-box zinc finger zf-HIT PF04438.16 KOO30462.1 - 2.6 8.0 5.0 5.2 7.0 5.0 1.5 1 0 0 1 1 1 0 HIT zinc finger 2-oxoacid_dh PF00198.23 KOO30463.1 - 4.7e-75 252.0 0.0 5.3e-75 251.8 0.0 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) HTH_10 PF04967.12 KOO30463.1 - 0.053 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain UQ_con PF00179.26 KOO30464.1 - 1.1e-53 180.6 0.0 1.2e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOO30464.1 - 0.0002 21.6 0.0 0.00029 21.1 0.0 1.4 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 KOO30464.1 - 0.0019 17.9 0.0 0.0023 17.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KOO30464.1 - 0.068 13.0 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 UEV domain Filamin PF00630.19 KOO30465.1 - 1.8e-12 47.9 0.0 0.0012 19.6 0.1 3.8 3 1 0 3 3 3 3 Filamin/ABP280 repeat Dam PF05869.11 KOO30465.1 - 0.004 16.7 0.0 0.0067 16.0 0.0 1.2 1 0 0 1 1 1 1 DNA N-6-adenine-methyltransferase (Dam) Guanylate_cyc PF00211.20 KOO30466.1 - 1.9e-19 70.0 0.0 2.9e-10 40.1 0.0 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain cNMP_binding PF00027.29 KOO30466.1 - 8.9e-18 64.2 0.1 2e-17 63.0 0.1 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain AAA_16 PF13191.6 KOO30466.1 - 4.3e-10 40.2 0.5 2.7e-09 37.6 0.5 2.5 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 KOO30466.1 - 0.003 17.5 0.2 0.076 12.9 0.2 2.9 2 1 0 2 2 2 1 NACHT domain TPR_12 PF13424.6 KOO30466.1 - 0.0043 17.3 11.8 0.44 10.9 0.7 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat AAA_22 PF13401.6 KOO30466.1 - 0.0064 16.8 0.0 0.18 12.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF2791 PF10923.8 KOO30466.1 - 0.041 12.7 0.0 1.3 7.8 0.0 2.2 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) Sel1 PF08238.12 KOO30466.1 - 0.083 13.6 0.3 0.26 12.0 0.3 1.9 1 0 0 1 1 1 0 Sel1 repeat Zeta_toxin PF06414.12 KOO30466.1 - 0.18 11.1 0.0 0.54 9.5 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin DHHC PF01529.20 KOO30467.1 - 1.8e-31 109.0 4.4 1.8e-31 109.0 4.4 2.4 3 0 0 3 3 3 1 DHHC palmitoyltransferase ENOD93 PF03386.14 KOO30468.1 - 0.0053 16.6 0.5 0.0097 15.8 0.5 1.4 1 0 0 1 1 1 1 Early nodulin 93 ENOD93 protein Cofac_haem_bdg PF04187.13 KOO30469.1 - 1.4e-28 100.4 0.1 1.8e-28 100.0 0.1 1.1 1 0 0 1 1 1 1 Haem-binding uptake, Tiki superfamily, ChaN Ank_2 PF12796.7 KOO30471.1 - 9e-42 141.6 0.1 1.1e-15 58.0 0.0 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO30471.1 - 1e-31 108.9 4.0 3.3e-10 40.3 0.0 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO30471.1 - 7.3e-26 87.4 2.7 2.3e-05 24.4 0.0 5.5 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 KOO30471.1 - 1.7e-23 81.9 2.2 0.00046 20.5 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KOO30471.1 - 8.1e-23 80.2 5.0 1.1e-08 35.1 0.0 5.3 2 1 3 5 5 5 4 Ankyrin repeats (many copies) NMT1_2 PF13379.6 KOO30471.1 - 0.026 14.2 0.1 0.05 13.3 0.1 1.4 1 1 0 1 1 1 0 NMT1-like family ketoacyl-synt PF00109.26 KOO30472.1 - 2.5e-58 197.6 0.0 8.1e-58 196.0 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 KOO30472.1 - 2.7e-47 161.0 0.4 5.3e-44 150.3 0.0 2.9 3 0 0 3 3 2 2 KR domain Acyl_transf_1 PF00698.21 KOO30472.1 - 3.6e-46 158.1 0.0 7.9e-46 157.0 0.0 1.6 1 0 0 1 1 1 1 Acyl transferase domain NAD_binding_4 PF07993.12 KOO30472.1 - 1.9e-39 135.4 0.0 4e-39 134.3 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein Sulfotransfer_3 PF13469.6 KOO30472.1 - 3e-30 106.2 0.5 6.2e-30 105.2 0.5 1.6 1 0 0 1 1 1 1 Sulfotransferase family Ketoacyl-synt_C PF02801.22 KOO30472.1 - 5.7e-26 90.9 0.7 1.9e-25 89.2 0.7 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 KOO30472.1 - 3.3e-24 85.6 0.0 6.1e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_zinc_N PF00107.26 KOO30472.1 - 1.2e-17 64.2 1.5 2.2e-16 60.0 0.4 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 KOO30472.1 - 5.7e-15 55.8 0.0 2e-14 54.0 0.0 1.9 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 KOO30472.1 - 2e-10 40.5 0.0 3e-08 33.4 0.0 2.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ADH_zinc_N_2 PF13602.6 KOO30472.1 - 7.8e-10 39.9 0.0 2.6e-09 38.2 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 KOO30472.1 - 4.1e-06 26.4 0.1 0.00044 19.8 0.0 2.7 2 0 0 2 2 2 1 short chain dehydrogenase ADH_N PF08240.12 KOO30472.1 - 2.4e-05 24.2 0.1 6.1e-05 22.9 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 KOO30472.1 - 0.00036 20.8 0.0 0.0017 18.7 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site GDP_Man_Dehyd PF16363.5 KOO30472.1 - 0.0054 16.2 0.0 0.033 13.6 0.0 2.2 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Sulfotransfer_4 PF17784.1 KOO30472.1 - 0.011 15.6 1.1 0.4 10.5 0.5 2.5 2 0 0 2 2 2 0 Sulfotransferase domain Piwi PF02171.17 KOO30473.1 - 9.4e-20 71.0 0.1 1.5e-19 70.4 0.1 1.3 1 0 0 1 1 1 1 Piwi domain PDZ PF00595.24 KOO30474.1 - 0.00099 19.4 0.0 0.0027 18.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain NPV_P10 PF05531.12 KOO30474.1 - 0.039 14.4 6.4 2.9 8.4 1.5 3.9 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein ACCA PF03255.14 KOO30474.1 - 0.045 13.6 0.3 0.045 13.6 0.3 4.5 5 0 0 5 5 5 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Arena_nucleocap PF00843.17 KOO30475.1 - 0.053 12.4 0.1 0.074 12.0 0.1 1.2 1 0 0 1 1 1 0 Arenavirus nucleocapsid N-terminal domain tRNA-synt_1c PF00749.21 KOO30477.1 - 3.2e-91 305.5 0.0 3.2e-91 305.5 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KOO30477.1 - 4e-26 91.9 0.0 1.3e-25 90.3 0.0 1.9 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain WHEP-TRS PF00458.20 KOO30477.1 - 2.6e-10 40.3 0.6 1.1e-09 38.2 0.6 2.2 1 0 0 1 1 1 1 WHEP-TRS domain GST_C_2 PF13410.6 KOO30477.1 - 0.0018 18.3 0.0 0.0058 16.6 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOO30477.1 - 0.003 17.7 1.8 0.0052 17.0 0.0 2.4 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.19 KOO30477.1 - 0.47 9.8 0.0 0.47 9.8 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain DUF3883 PF13020.6 KOO30479.1 - 0.15 12.1 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) JmjC PF02373.22 KOO30481.1 - 0.018 15.5 0.0 0.036 14.5 0.0 1.6 1 1 0 1 1 1 0 JmjC domain, hydroxylase DUF3994 PF13159.6 KOO30483.1 - 0.11 13.0 11.8 19 5.9 0.1 5.6 5 0 0 5 5 5 0 Domain of unknown function (DUF3994) Flavoprotein PF02441.19 KOO30483.1 - 0.71 9.6 5.6 1.8 8.3 1.3 3.0 2 0 0 2 2 2 0 Flavoprotein DNA_ligase_A_C PF04679.15 KOO30483.1 - 1 10.0 8.2 25 5.5 0.0 5.2 4 2 0 4 4 4 0 ATP dependent DNA ligase C terminal region RVT_1 PF00078.27 KOO30485.1 - 6.4e-14 52.0 0.0 9.9e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KOO30485.1 - 9.4e-05 22.7 0.0 0.00043 20.5 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KOO30485.1 - 0.00051 20.0 0.0 0.0015 18.5 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Mito_carr PF00153.27 KOO30486.1 - 1.1e-39 134.2 1.0 1.3e-13 50.7 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein ARL2_Bind_BART PF11527.8 KOO30486.1 - 7.4e-16 58.3 0.0 1.4e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART DUF3437 PF11919.8 KOO30486.1 - 0.1 12.5 0.0 5.5 7.0 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) Pkinase PF00069.25 KOO30487.1 - 1.2e-59 201.8 0.1 1.5e-59 201.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30487.1 - 1.6e-39 135.8 0.0 2.1e-39 135.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO30487.1 - 7e-07 28.9 0.0 1.5e-06 27.8 0.0 1.4 2 0 0 2 2 2 1 Kinase-like HIT PF01230.23 KOO30487.1 - 7.9e-06 26.5 0.0 1.6e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 HIT domain Pkinase_fungal PF17667.1 KOO30487.1 - 6.9e-05 21.8 0.0 0.0001 21.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase CoA_binding PF02629.19 KOO30488.1 - 0.16 12.7 0.3 2 9.1 0.0 2.7 4 0 0 4 4 4 0 CoA binding domain DUF3613 PF12266.8 KOO30488.1 - 0.39 10.5 4.4 0.13 12.0 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3613) PH PF00169.29 KOO30490.1 - 2.6e-18 66.4 0.0 2.8e-05 24.6 0.0 5.2 5 0 0 5 5 5 4 PH domain PH_8 PF15409.6 KOO30490.1 - 1e-09 38.5 2.9 0.0019 18.4 0.0 5.4 6 0 0 6 6 6 3 Pleckstrin homology domain PH_11 PF15413.6 KOO30490.1 - 0.0019 18.6 3.5 0.044 14.2 0.1 4.2 5 0 0 5 5 5 1 Pleckstrin homology domain RAMA PF18755.1 KOO30490.1 - 0.0091 16.4 6.8 0.61 10.5 1.3 3.8 1 1 2 3 3 3 2 Restriction Enzyme Adenine Methylase Associated Glycos_transf_2 PF00535.26 KOO30491.1 - 8.2e-15 55.0 0.0 1.6e-14 54.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 KOO30491.1 - 5.4e-09 35.6 0.0 9.5e-09 34.8 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 KOO30491.1 - 4.8e-06 26.6 0.1 1e-05 25.5 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 GlcNAc PF11397.8 KOO30491.1 - 0.025 14.0 0.0 0.038 13.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase (GlcNAc) Glyco_tranf_2_2 PF10111.9 KOO30491.1 - 0.039 13.4 0.0 4.7 6.6 0.0 2.3 2 0 0 2 2 2 0 Glycosyltransferase like family 2 UcrQ PF02939.16 KOO30492.1 - 5.3e-05 23.1 0.1 7.9e-05 22.5 0.1 1.3 1 1 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 KOO30492.1 - 0.027 14.8 0.4 0.092 13.2 0.4 1.7 1 1 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 Peptidase_C2 PF00648.21 KOO30493.1 - 1.1e-76 257.7 0.0 1.6e-76 257.2 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Chlam_PMP PF02415.17 KOO30498.1 - 0.00031 21.0 0.7 0.088 13.3 0.1 3.1 3 0 0 3 3 3 2 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat TPR_17 PF13431.6 KOO30498.1 - 0.027 14.8 0.0 0.15 12.5 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_6 PF13516.6 KOO30499.1 - 2.8e-05 23.8 1.4 0.29 11.3 0.0 3.7 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.7 KOO30499.1 - 0.18 12.3 1.8 2.7 8.6 0.0 3.3 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) HEAT_2 PF13646.6 KOO30500.1 - 2e-21 76.2 25.9 0.0006 20.1 0.2 8.3 3 3 2 7 7 7 7 HEAT repeats HEAT PF02985.22 KOO30500.1 - 8.2e-15 53.7 20.6 1.1 9.7 0.1 11.3 11 0 0 11 11 11 5 HEAT repeat Adaptin_N PF01602.20 KOO30500.1 - 1.1e-07 30.8 8.9 0.0032 16.1 0.0 4.2 3 1 1 4 4 4 3 Adaptin N terminal region HEAT_EZ PF13513.6 KOO30500.1 - 2.1e-07 31.3 20.5 2.7 8.6 0.0 9.2 7 2 3 10 10 10 4 HEAT-like repeat Cnd1 PF12717.7 KOO30500.1 - 3.2e-07 30.5 10.8 2.3 8.2 0.9 6.1 5 1 1 6 6 6 3 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 KOO30500.1 - 0.041 14.6 2.0 29 5.7 0.1 4.5 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Kinocilin PF15033.6 KOO30500.1 - 0.068 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Kinocilin protein Cohesin_HEAT PF12765.7 KOO30500.1 - 0.17 12.2 0.2 0.17 12.2 0.2 4.7 4 1 1 5 5 5 0 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.8 KOO30500.1 - 0.65 9.5 8.3 2.1 7.9 0.1 4.8 5 2 2 7 7 7 0 CLASP N terminal ALF PF03752.13 KOO30500.1 - 8.6 6.4 9.5 5.2 7.1 0.8 3.5 3 0 0 3 3 3 0 Short repeats of unknown function Ion_trans_2 PF07885.16 KOO30501.1 - 2.4e-30 104.3 12.9 1.8e-16 59.8 6.4 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KOO30501.1 - 9.7e-08 31.5 1.5 0.0037 16.5 0.1 2.3 1 1 0 2 2 2 2 Ion transport protein IRK PF01007.20 KOO30501.1 - 0.054 13.3 0.2 0.96 9.3 0.0 2.5 3 0 0 3 3 3 0 Inward rectifier potassium channel transmembrane domain PDZ PF00595.24 KOO30502.1 - 1.3e-05 25.5 0.0 3.5e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 PDZ domain DUF2587 PF10759.9 KOO30502.1 - 0.00034 20.2 4.3 0.19 11.3 0.6 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF2587) PDZ_6 PF17820.1 KOO30502.1 - 0.00095 19.0 0.0 0.0033 17.2 0.0 2.0 1 0 0 1 1 1 1 PDZ domain DUF2786 PF10979.8 KOO30502.1 - 0.014 15.3 11.8 0.13 12.2 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2786) PDZ_2 PF13180.6 KOO30502.1 - 0.017 15.5 0.7 0.051 13.9 0.0 2.1 2 0 0 2 2 2 0 PDZ domain DUF2001 PF09393.10 KOO30502.1 - 0.031 14.3 0.5 7.7 6.5 0.0 2.4 2 0 0 2 2 2 0 Phage tail tube protein UPF0149 PF03695.13 KOO30502.1 - 0.034 14.4 0.2 0.35 11.1 0.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0149) DUF4079 PF13301.6 KOO30502.1 - 0.057 13.6 0.1 8.2 6.6 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) IQ PF00612.27 KOO30502.1 - 0.067 13.0 10.7 1.3 9.0 0.7 3.3 3 0 0 3 3 3 0 IQ calmodulin-binding motif SPARC_Ca_bdg PF10591.9 KOO30502.1 - 0.068 13.5 0.2 13 6.2 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF5427 PF10310.9 KOO30502.1 - 9.2 5.1 18.5 3.4 6.5 1.8 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5427) FlaC_arch PF05377.11 KOO30504.1 - 0.1 13.0 0.4 0.53 10.7 0.3 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4618 PF15397.6 KOO30504.1 - 0.16 11.4 8.3 1.4 8.3 2.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) HC2 PF07382.11 KOO30504.1 - 1.3 9.0 32.5 0.034 14.2 25.6 1.8 2 0 0 2 2 2 0 Histone H1-like nucleoprotein HC2 AAA_13 PF13166.6 KOO30504.1 - 1.7 7.2 12.1 1.4 7.5 5.3 2.3 2 0 0 2 2 2 0 AAA domain TPK_catalytic PF04263.16 KOO30505.1 - 6.4e-28 97.2 0.0 3.3e-27 94.9 0.0 2.1 2 1 0 2 2 2 1 Thiamin pyrophosphokinase, catalytic domain EF-hand_1 PF00036.32 KOO30505.1 - 8e-27 90.8 4.0 6.1e-06 25.4 0.0 5.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO30505.1 - 2e-23 82.0 4.0 7.3e-05 22.5 0.1 5.8 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_7 PF13499.6 KOO30505.1 - 1.7e-22 79.6 0.6 1.8e-09 37.9 0.1 3.6 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO30505.1 - 3.7e-18 63.8 1.9 0.0014 18.4 0.1 5.8 5 1 1 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 KOO30505.1 - 5.7e-18 63.5 2.6 0.0011 18.4 0.0 5.4 4 1 1 5 5 5 4 EF hand TPK_B1_binding PF04265.14 KOO30505.1 - 1.3e-16 60.0 0.0 2.5e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain RIIa PF02197.17 KOO30505.1 - 2e-11 43.4 0.6 4.1e-11 42.4 0.6 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EF-hand_4 PF12763.7 KOO30505.1 - 1.7e-06 27.9 3.7 1.5 8.8 0.0 5.6 2 1 4 6 6 6 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO30505.1 - 5.9e-06 26.6 0.4 0.3 11.4 0.0 3.4 1 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO30505.1 - 0.031 14.1 5.2 7.3 6.5 0.2 4.1 4 1 1 5 5 5 0 EF hand APG6_N PF17675.1 KOO30505.1 - 3.5 8.2 7.0 0.63 10.6 0.2 2.7 3 0 0 3 3 3 0 Apg6 coiled-coil region Nucleotid_trans PF03407.16 KOO30506.1 - 1.7e-06 28.2 0.0 4.7e-06 26.7 0.0 1.7 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase Pkinase PF00069.25 KOO30508.1 - 3.4e-33 115.1 0.0 1.1e-32 113.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30508.1 - 1.8e-10 40.5 0.0 3.9e-10 39.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Fez1 PF06818.15 KOO30508.1 - 0.00063 20.3 12.5 0.0013 19.2 12.5 1.4 1 1 0 1 1 1 1 Fez1 TMF_TATA_bd PF12325.8 KOO30508.1 - 0.017 15.3 13.0 0.078 13.2 10.2 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding EF-hand_1 PF00036.32 KOO30508.1 - 0.017 14.6 1.7 1.9 8.2 1.5 2.6 2 0 0 2 2 2 0 EF hand Pkinase_fungal PF17667.1 KOO30508.1 - 0.049 12.4 0.6 0.11 11.2 0.0 1.8 3 0 0 3 3 3 0 Fungal protein kinase TolA_bind_tri PF16331.5 KOO30508.1 - 0.15 12.2 2.4 1.2 9.3 0.1 3.0 3 0 0 3 3 3 0 TolA binding protein trimerisation THOC7 PF05615.13 KOO30508.1 - 0.15 12.3 10.2 2.5 8.4 7.2 2.5 2 0 0 2 2 2 0 Tho complex subunit 7 Spc7 PF08317.11 KOO30508.1 - 1.5 7.6 13.4 5.3 5.8 0.2 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Ribosomal_60s PF00428.19 KOO30508.1 - 2.1 9.0 16.1 3.5 8.3 0.6 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein UPF0242 PF06785.11 KOO30508.1 - 2.5 8.1 6.3 37 4.3 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 KOO30508.1 - 2.7 7.3 13.9 9.4 5.5 9.1 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.7 KOO30508.1 - 3 8.0 19.5 0.11 12.6 0.4 2.6 2 1 0 2 2 2 0 Tropomyosin like HAUS6_N PF14661.6 KOO30508.1 - 5.7 6.4 11.6 3 7.4 0.3 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus BRCT_2 PF16589.5 KOO30509.1 - 1.9e-07 31.4 0.0 0.018 15.4 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KOO30509.1 - 6.1e-05 23.3 0.0 0.097 13.1 0.0 2.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 KOO30509.1 - 0.1 12.5 0.0 4 7.4 0.0 2.3 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Nop14 PF04147.12 KOO30509.1 - 2.4 6.3 10.4 2.9 6.0 10.4 1.1 1 0 0 1 1 1 0 Nop14-like family DUF572 PF04502.13 KOO30509.1 - 9.3 5.8 7.8 13 5.3 7.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Arm PF00514.23 KOO30510.1 - 2.4e-24 84.5 3.6 9e-05 22.4 0.1 6.2 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KOO30510.1 - 0.063 13.6 5.9 82 3.9 0.0 5.1 5 0 0 5 5 5 0 HEAT repeat Retinal PF15449.6 KOO30510.1 - 1.9 6.2 12.4 2.3 5.9 12.4 1.0 1 0 0 1 1 1 0 Retinal protein HEAT_EZ PF13513.6 KOO30510.1 - 2 9.0 12.1 0.21 12.2 2.3 3.8 3 1 2 5 5 5 0 HEAT-like repeat TPR_10 PF13374.6 KOO30511.1 - 6.4e-112 362.9 51.0 6.8e-12 44.9 0.0 14.4 14 0 0 14 14 14 13 Tetratricopeptide repeat TPR_12 PF13424.6 KOO30511.1 - 1.3e-110 361.8 100.7 5.3e-14 52.3 0.1 10.9 1 1 13 14 14 14 12 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30511.1 - 3.1e-35 117.4 27.9 0.0028 17.8 0.1 12.7 13 0 0 13 13 12 11 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO30511.1 - 7.2e-33 114.4 27.1 4.8e-10 39.3 4.8 5.2 1 1 4 5 5 5 5 MalT-like TPR region TPR_1 PF00515.28 KOO30511.1 - 9e-31 104.4 29.5 0.029 14.2 0.1 12.4 12 0 0 12 12 12 10 Tetratricopeptide repeat TPR_7 PF13176.6 KOO30511.1 - 2.1e-28 96.2 45.2 0.031 14.3 0.2 13.0 13 0 0 13 13 13 10 Tetratricopeptide repeat TPR_2 PF07719.17 KOO30511.1 - 5.1e-23 79.3 43.8 0.062 13.4 0.2 12.9 13 0 0 13 13 12 10 Tetratricopeptide repeat TPR_4 PF07721.14 KOO30511.1 - 4.7e-21 73.2 35.2 0.054 14.1 0.3 14.7 13 0 0 13 13 13 3 Tetratricopeptide repeat TPR_3 PF07720.12 KOO30511.1 - 2.9e-16 59.1 0.3 0.86 9.7 0.0 10.6 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO30511.1 - 7.8e-12 44.7 12.8 3.6 8.2 0.0 11.0 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO30511.1 - 1.1e-10 42.0 49.1 0.043 14.5 0.8 11.9 6 3 3 9 9 9 5 Tetratricopeptide repeat TPR_5 PF12688.7 KOO30511.1 - 5.7e-10 39.5 37.4 0.0036 17.5 2.0 6.5 2 1 4 6 6 6 4 Tetratrico peptide repeat TPR_19 PF14559.6 KOO30511.1 - 3.6e-07 30.6 43.4 1.2 9.6 1.6 8.9 5 2 4 9 9 9 5 Tetratricopeptide repeat RPN6_N PF18055.1 KOO30511.1 - 6.2e-07 29.8 9.4 2.5 8.5 0.0 6.8 4 3 4 8 8 8 3 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_14 PF13428.6 KOO30511.1 - 8.3e-06 26.2 55.0 2.4 9.2 0.4 13.5 12 2 2 14 14 13 3 Tetratricopeptide repeat Sec16_C PF12931.7 KOO30511.1 - 0.00014 21.6 6.0 14 5.2 0.0 7.0 3 2 3 7 7 7 0 Sec23-binding domain of Sec16 MIT PF04212.18 KOO30511.1 - 0.0005 20.1 7.1 23 5.1 0.0 6.9 6 1 0 7 7 7 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 KOO30511.1 - 0.0031 17.2 27.8 3.2 7.5 0.1 9.8 11 0 0 11 11 11 2 TPR repeat SPESP1 PF15754.5 KOO30511.1 - 0.03 13.5 0.1 13 4.8 0.0 4.1 2 1 1 4 4 4 0 Sperm equatorial segment protein 1 TPR_20 PF14561.6 KOO30511.1 - 0.2 12.0 22.0 1.2 9.5 0.1 6.2 3 3 4 8 8 7 0 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO30511.1 - 0.31 11.3 16.0 95 3.4 0.2 9.0 11 0 0 11 11 10 0 Osmosensory transporter coiled coil Arm PF00514.23 KOO30512.1 - 1.3e-08 34.6 0.3 2.3e-05 24.2 0.0 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Citrate_synt PF00285.21 KOO30513.1 - 6e-105 351.3 0.0 7.3e-105 351.0 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain HTH_Tnp_Tc5 PF03221.16 KOO30513.1 - 0.1 12.6 0.1 0.91 9.6 0.0 2.2 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain Filamin PF00630.19 KOO30514.1 - 3.4e-44 149.9 0.0 1e-12 48.8 0.0 7.2 6 1 0 6 6 6 6 Filamin/ABP280 repeat CAP_GLY PF01302.25 KOO30514.1 - 1.6e-15 56.8 1.7 3.3e-15 55.8 1.7 1.6 1 0 0 1 1 1 1 CAP-Gly domain Invasin_D3 PF09134.10 KOO30514.1 - 5.3e-14 52.3 4.4 6.5e-07 29.6 0.2 5.0 5 0 0 5 5 5 2 Invasin, domain 3 Big_1 PF02369.16 KOO30514.1 - 0.001 19.0 0.1 0.019 14.9 0.1 3.2 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) Cadherin_5 PF17892.1 KOO30514.1 - 0.004 17.1 0.1 1.2 9.2 0.0 3.3 3 0 0 3 3 3 1 Cadherin-like domain Neurexophilin PF06312.12 KOO30514.1 - 0.016 14.7 0.0 0.37 10.2 0.0 2.2 2 0 0 2 2 2 0 Neurexophilin 2-Hacid_dh_C PF02826.19 KOO30515.1 - 2.6e-33 114.9 0.0 8.5e-30 103.4 0.0 2.2 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.6 KOO30515.1 - 0.0042 17.6 0.0 0.0077 16.7 0.0 1.4 1 0 0 1 1 1 1 XdhC Rossmann domain U-box PF04564.15 KOO30516.1 - 8.5e-12 45.1 0.0 1.9e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain SH3_15 PF18346.1 KOO30516.1 - 5e-05 23.5 0.6 0.8 10.1 0.0 3.8 3 0 0 3 3 3 2 Mind bomb SH3 repeat domain C1_2 PF03107.16 KOO30516.1 - 0.0012 19.1 2.9 0.0021 18.3 2.9 1.4 1 0 0 1 1 1 1 C1 domain zf-Nse PF11789.8 KOO30516.1 - 0.0059 16.4 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO30516.1 - 0.012 15.7 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein LRR_5 PF13306.6 KOO30517.1 - 3e-102 337.6 3.0 1.6e-35 121.8 0.1 3.1 3 0 0 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO30517.1 - 1.6e-16 59.8 0.0 0.22 11.3 0.0 9.4 5 3 7 12 12 12 8 Leucine rich repeat ZZ PF00569.17 KOO30517.1 - 0.00013 21.7 0.0 0.00032 20.5 0.0 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type LRR_4 PF12799.7 KOO30517.1 - 0.00017 21.9 0.0 10 6.7 0.0 4.9 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) MT PF12777.7 KOO30517.1 - 0.0055 15.8 0.0 1 8.3 0.0 2.9 3 0 0 3 3 3 1 Microtubule-binding stalk of dynein motor Peptidase_M8 PF01457.16 KOO30517.1 - 0.01 14.6 8.5 3.8 6.1 0.2 5.1 3 3 1 5 5 5 0 Leishmanolysin PilA4 PF18682.1 KOO30517.1 - 0.015 15.6 17.5 12 6.3 0.4 8.1 4 3 6 10 10 10 0 Pilin A4 ZF-HD_dimer PF04770.12 KOO30517.1 - 0.074 13.4 1.1 4.3 7.7 0.0 3.8 5 0 0 5 5 5 0 ZF-HD protein dimerisation region IncF PF17626.2 KOO30517.1 - 7.5 7.0 9.2 35 4.8 1.1 4.0 3 2 0 3 3 3 0 Inclusion membrane protein F LRR_5 PF13306.6 KOO30519.1 - 1.1e-23 83.5 0.0 1.8e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Dpy-30 PF05186.13 KOO30519.1 - 0.023 14.4 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 Dpy-30 motif PilA4 PF18682.1 KOO30519.1 - 0.13 12.7 1.9 18 5.8 0.0 3.7 2 1 1 3 3 3 0 Pilin A4 Zip PF02535.22 KOO30520.1 - 1.7e-17 63.7 19.4 4e-09 36.1 2.9 2.3 1 1 1 2 2 2 2 ZIP Zinc transporter EAGR_box PF16713.5 KOO30520.1 - 0.028 14.1 1.1 0.052 13.2 1.1 1.4 1 0 0 1 1 1 0 Enriched in aromatic and glycine Residues box Tetraspanin PF00335.20 KOO30520.1 - 0.13 12.0 0.3 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 Tetraspanin family JAKMIP_CC3 PF16034.5 KOO30523.1 - 0.33 10.9 2.7 0.41 10.6 2.7 1.0 1 0 0 1 1 1 0 JAKMIP CC3 domain DDE_Tnp_1_6 PF13751.6 KOO30524.1 - 0.69 10.1 8.2 2.4 8.4 3.3 2.2 1 1 1 2 2 2 0 Transposase DDE domain LRR_5 PF13306.6 KOO30525.1 - 2.4e-98 325.0 0.0 3.8e-38 130.4 0.2 3.4 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) Adenylsucc_synt PF00709.21 KOO30525.1 - 2e-73 247.7 0.0 2.9e-73 247.2 0.0 1.2 1 0 0 1 1 1 1 Adenylosuccinate synthetase LRR_8 PF13855.6 KOO30525.1 - 5e-13 48.6 0.0 0.11 12.3 0.0 7.0 2 1 8 10 10 10 9 Leucine rich repeat SAF PF08666.12 KOO30528.1 - 0.0071 16.9 0.0 2.9 8.6 0.0 2.3 2 0 0 2 2 2 2 SAF domain Arb2 PF09757.9 KOO30528.1 - 0.019 14.1 0.0 3.3 6.8 0.0 2.1 2 0 0 2 2 2 0 Arb2 domain DUF1317 PF07026.11 KOO30528.1 - 0.03 14.1 0.1 18 5.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1317) Rod_cone_degen PF15201.6 KOO30528.1 - 0.058 13.5 0.0 14 5.8 0.0 2.4 2 0 0 2 2 2 0 Progressive rod-cone degeneration RmlD_sub_bind PF04321.17 KOO30528.1 - 0.17 11.0 0.0 0.61 9.1 0.0 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain Pkinase PF00069.25 KOO30530.1 - 3.4e-59 200.3 0.0 4e-59 200.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30530.1 - 7.6e-32 110.6 0.0 8.8e-32 110.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO30530.1 - 0.03 13.7 0.1 0.047 13.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOO30530.1 - 0.13 11.2 0.1 0.16 10.9 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KOO30530.1 - 0.17 11.8 0.2 1.3 8.9 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Asp_protease_2 PF13650.6 KOO30531.1 - 1.7e-11 44.6 6.0 3.3e-06 27.7 0.8 2.7 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 KOO30531.1 - 4.4e-11 43.2 5.6 8.9e-05 23.0 0.1 3.7 3 1 0 3 3 3 2 gag-polyprotein putative aspartyl protease RVP PF00077.20 KOO30531.1 - 0.0016 18.7 0.8 0.027 14.8 0.1 2.5 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease PF09668.10 KOO30531.1 - 0.0091 15.8 0.0 0.056 13.2 0.0 2.1 2 0 0 2 2 2 1 Aspartyl protease APG9 PF04109.16 KOO30532.1 - 4e-142 474.6 8.3 4.8e-142 474.3 8.3 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 RRM_1 PF00076.22 KOO30533.1 - 4.3e-14 52.1 0.0 5.8e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arm PF00514.23 KOO30535.1 - 1.8e-14 53.1 18.8 0.0015 18.5 0.0 8.9 10 0 0 10 10 10 4 Armadillo/beta-catenin-like repeat TPR_1 PF00515.28 KOO30535.1 - 2.1e-12 46.3 5.0 5.8e-05 22.7 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat UNC45-central PF11701.8 KOO30535.1 - 2.5e-09 37.3 11.9 4.3e-09 36.5 0.1 4.3 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central TPR_2 PF07719.17 KOO30535.1 - 3.7e-07 29.8 17.3 0.0068 16.4 0.1 4.3 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO30535.1 - 0.00039 20.0 2.4 0.035 13.8 0.2 2.8 2 1 0 2 2 2 1 TPR repeat TPR_8 PF13181.6 KOO30535.1 - 0.0029 17.7 2.8 0.17 12.2 0.1 3.5 3 0 0 3 3 2 1 Tetratricopeptide repeat HEAT_2 PF13646.6 KOO30535.1 - 0.0034 17.7 29.3 0.017 15.5 0.0 8.3 4 2 3 8 8 8 2 HEAT repeats TPR_16 PF13432.6 KOO30535.1 - 0.0046 17.6 0.9 0.0046 17.6 0.9 6.4 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO30535.1 - 0.006 16.8 2.9 1.2 9.4 0.7 3.4 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO30535.1 - 0.0082 16.5 3.8 0.41 11.1 0.6 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF383 PF04063.14 KOO30535.1 - 0.0082 15.8 0.1 6.3 6.4 0.1 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF383) RIX1 PF08167.12 KOO30535.1 - 0.0094 15.7 0.0 0.04 13.7 0.1 2.0 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Fis1_TPR_C PF14853.6 KOO30535.1 - 0.018 15.1 4.6 0.029 14.5 0.7 2.9 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat HEAT PF02985.22 KOO30535.1 - 0.037 14.3 12.4 1.7 9.1 0.0 6.2 6 0 0 6 6 6 0 HEAT repeat Cnd1 PF12717.7 KOO30535.1 - 0.059 13.4 1.5 4.2 7.4 0.1 2.9 3 0 0 3 3 2 0 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 KOO30535.1 - 0.084 13.0 1.3 3 8.0 0.1 3.2 3 0 0 3 3 3 0 V-ATPase subunit H Adaptin_N PF01602.20 KOO30535.1 - 0.17 10.4 0.6 4.4 5.7 0.1 3.1 3 1 0 3 3 3 0 Adaptin N terminal region 2OG-FeII_Oxy_3 PF13640.6 KOO30536.1 - 2.3e-14 54.0 0.0 2.3e-13 50.9 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO30536.1 - 5.6e-08 33.3 0.0 1e-07 32.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 KOO30536.1 - 0.17 12.3 0.1 0.51 10.8 0.1 1.9 1 1 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Med3 PF11593.8 KOO30536.1 - 1.8 7.7 3.5 2.3 7.3 3.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PRIMA1 PF16101.5 KOO30537.1 - 0.78 9.8 5.1 1.3 9.1 5.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 THF_DHG_CYH PF00763.23 KOO30538.1 - 6.3e-19 68.4 0.0 9.5e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 KOO30538.1 - 0.028 13.7 0.0 0.71 9.2 0.0 2.4 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PDZ_6 PF17820.1 KOO30540.1 - 1.5e-13 50.3 0.4 4.7e-06 26.4 0.0 3.7 4 0 0 4 4 4 2 PDZ domain PDZ PF00595.24 KOO30540.1 - 2.7e-09 37.3 0.0 0.00027 21.2 0.0 3.0 2 1 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KOO30540.1 - 5.4e-07 29.8 0.0 0.029 14.7 0.0 3.0 2 1 0 2 2 2 2 PDZ domain Tmpp129 PF10272.9 KOO30540.1 - 0.34 10.2 0.9 0.51 9.6 0.9 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor THP2 PF09432.10 KOO30540.1 - 0.38 10.8 3.2 0.88 9.6 3.2 1.6 1 0 0 1 1 1 0 Tho complex subunit THP2 Frag1 PF10277.9 KOO30541.1 - 3.5e-13 49.6 18.1 3.6e-11 43.0 3.8 2.7 2 2 0 2 2 2 2 Frag1/DRAM/Sfk1 family PrmA PF06325.13 KOO30542.1 - 6.3e-10 38.9 0.0 9e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 KOO30542.1 - 3.4e-06 26.9 0.0 5.1e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.19 KOO30542.1 - 4.3e-05 23.4 0.0 6.9e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 KOO30542.1 - 6.6e-05 22.6 0.0 0.00012 21.8 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 RrnaAD PF00398.20 KOO30542.1 - 0.00042 19.5 0.0 0.00066 18.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 KOO30542.1 - 0.00075 20.2 0.0 0.0029 18.3 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOO30542.1 - 0.0016 18.4 0.0 0.003 17.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KOO30542.1 - 0.0036 17.2 0.0 0.0057 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO30542.1 - 0.015 14.8 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_3 PF01596.17 KOO30542.1 - 0.017 14.3 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_23 PF13489.6 KOO30542.1 - 0.017 14.9 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KOO30542.1 - 0.02 14.7 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 KOO30542.1 - 0.036 15.1 0.1 0.11 13.6 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 KOO30542.1 - 0.073 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_16 PF10294.9 KOO30542.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase LRR_6 PF13516.6 KOO30543.1 - 1.3e-12 46.7 1.6 0.00018 21.3 0.0 3.9 3 0 0 3 3 3 3 Leucine Rich repeat ResIII PF04851.15 KOO30543.1 - 3.7e-05 23.8 0.0 0.0017 18.4 0.0 2.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 KOO30543.1 - 0.00071 19.1 0.0 0.0015 18.1 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein AAA_22 PF13401.6 KOO30543.1 - 0.081 13.2 0.4 2.8 8.2 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF3197 PF11432.8 KOO30543.1 - 0.19 11.6 1.1 1.2 9.0 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3197) RVT_1 PF00078.27 KOO30544.1 - 1.2e-12 47.9 0.0 2e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_6 PF13516.6 KOO30545.1 - 8.6e-05 22.3 0.2 0.00045 20.1 0.1 2.1 2 0 0 2 2 2 1 Leucine Rich repeat zf-CCHC PF00098.23 KOO30546.1 - 0.036 14.2 0.2 0.065 13.3 0.2 1.5 1 0 0 1 1 1 0 Zinc knuckle S_4TM PF18159.1 KOO30548.1 - 0.013 14.8 0.7 0.017 14.4 0.7 1.1 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain DUF5065 PF16723.5 KOO30549.1 - 0.042 13.9 0.1 0.078 13.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5065) Pkinase PF00069.25 KOO30551.1 - 2.4e-41 141.9 0.0 5.8e-41 140.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30551.1 - 4.9e-21 75.2 0.0 6.9e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NTP_transf_3 PF12804.7 KOO30551.1 - 1.6e-07 31.8 0.1 4.5e-07 30.4 0.1 1.7 1 0 0 1 1 1 1 MobA-like NTP transferase domain Kinase-like PF14531.6 KOO30551.1 - 1.9e-05 24.2 0.0 2.7e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like NTP_transferase PF00483.23 KOO30551.1 - 0.0099 15.5 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase APH PF01636.23 KOO30551.1 - 0.033 14.1 3.1 0.16 11.8 0.7 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Peptidase_M16 PF00675.20 KOO30552.1 - 9e-32 110.1 0.0 1.6e-31 109.3 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) PriCT_1 PF08708.11 KOO30552.1 - 0.021 14.5 1.1 0.18 11.6 0.1 2.7 3 1 0 3 3 3 0 Primase C terminal 1 (PriCT-1) Carbpep_Y_N PF05388.11 KOO30553.1 - 0.093 13.3 0.1 0.11 13.0 0.1 1.2 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide Abhydrolase_2 PF02230.16 KOO30554.1 - 6.5e-48 163.4 0.0 7.8e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 KOO30554.1 - 1.8e-09 37.3 0.0 0.0011 18.4 0.0 2.7 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOO30554.1 - 1.4e-08 34.5 0.1 1.8e-06 27.6 0.0 2.3 1 1 1 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.13 KOO30554.1 - 5.4e-08 32.8 0.0 1.6e-07 31.2 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 KOO30554.1 - 1.2e-07 31.5 0.0 1.5e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 KOO30554.1 - 5.8e-07 29.4 0.0 1.1e-05 25.3 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOO30554.1 - 1.9e-05 25.4 0.6 2.4e-05 25.0 0.6 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KOO30554.1 - 0.00011 22.1 0.1 0.15 11.9 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Esterase PF00756.20 KOO30554.1 - 0.00012 21.8 0.1 0.0011 18.7 0.0 2.0 2 0 0 2 2 2 1 Putative esterase Esterase_phd PF10503.9 KOO30554.1 - 0.00023 20.7 0.4 0.019 14.5 0.0 2.3 2 1 1 3 3 3 1 Esterase PHB depolymerase Abhydrolase_5 PF12695.7 KOO30554.1 - 0.0026 17.5 0.0 0.0035 17.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 KOO30554.1 - 0.0064 16.4 0.0 0.0086 15.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 KOO30554.1 - 0.0066 16.0 0.0 0.0084 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) BAAT_C PF08840.11 KOO30554.1 - 0.0066 16.4 0.1 0.64 9.9 0.2 2.1 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF829 PF05705.14 KOO30554.1 - 0.032 14.1 0.0 0.61 9.9 0.0 2.0 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF829) DUF2048 PF09752.9 KOO30554.1 - 0.044 12.9 0.0 0.061 12.4 0.0 1.2 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Cutinase PF01083.22 KOO30554.1 - 0.076 13.0 0.0 0.14 12.1 0.0 1.4 1 1 0 1 1 1 0 Cutinase EF-hand_8 PF13833.6 KOO30555.1 - 7.9e-12 44.8 0.8 0.00032 20.5 0.0 3.7 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO30555.1 - 1.1e-11 43.7 0.0 2.3e-07 30.2 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 KOO30555.1 - 1.2e-11 44.9 0.1 1.2e-08 35.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO30555.1 - 1.4e-11 43.1 0.1 1.9e-07 30.1 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 KOO30555.1 - 2.8e-09 37.1 0.0 1e-08 35.4 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO30555.1 - 0.0038 16.6 0.0 0.035 13.6 0.0 2.5 3 0 0 3 3 3 1 EF hand EF-hand_like PF09279.11 KOO30555.1 - 0.0075 16.7 0.0 1.4 9.5 0.0 2.9 1 1 2 3 3 3 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_14 PF17959.1 KOO30555.1 - 0.046 14.1 0.0 2 8.8 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain SurA_N_3 PF13624.6 KOO30555.1 - 0.12 12.2 0.5 0.42 10.4 0.1 1.8 2 0 0 2 2 2 0 SurA N-terminal domain DUF3008 PF11450.8 KOO30555.1 - 0.16 12.1 0.3 0.5 10.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknwon function (DUF3008) MIEAP PF16026.5 KOO30556.1 - 5.8 7.1 10.3 0.44 10.7 5.2 1.6 2 0 0 2 2 2 0 Mitochondria-eating protein PH PF00169.29 KOO30558.1 - 8.4e-08 32.7 0.0 2.6e-07 31.1 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 KOO30558.1 - 0.029 14.7 0.2 0.58 10.5 0.0 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.6 KOO30558.1 - 0.13 12.7 0.9 1.1 9.7 0.0 2.9 3 1 0 3 3 3 0 Pleckstrin homology domain PH_8 PF15409.6 KOO30558.1 - 0.14 12.4 0.0 33 4.9 0.0 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain ETRAMP PF09716.10 KOO30558.1 - 0.14 12.2 3.1 0.28 11.3 0.0 2.3 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Golgin_A5 PF09787.9 KOO30558.1 - 2.9 7.3 19.4 13 5.1 16.2 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 TFIIA PF03153.13 KOO30558.1 - 4.2 7.3 16.1 6 6.8 16.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PGPGW PF09656.10 KOO30559.1 - 0.061 12.8 1.3 0.1 12.1 0.1 2.0 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) MFS_MOT1 PF16983.5 KOO30560.1 - 6e-21 74.9 22.4 9.2e-14 51.8 6.3 2.7 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily CENP-K PF11802.8 KOO30561.1 - 0.7 9.4 6.9 0.94 9.0 6.9 1.2 1 0 0 1 1 1 0 Centromere-associated protein K NPV_P10 PF05531.12 KOO30561.1 - 1.1 9.8 2.7 34 5.0 0.2 3.0 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4600 PF15372.6 KOO30561.1 - 7.5 7.0 9.9 2.8 8.4 1.9 2.7 1 1 1 3 3 3 0 Domain of unknown function (DUF4600) HD PF01966.22 KOO30562.1 - 6.9e-08 32.8 0.0 1.6e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 HD domain PhyH PF05721.13 KOO30562.1 - 6.5e-06 26.5 0.0 0.00011 22.5 0.0 2.2 1 1 1 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 KOO30562.1 - 0.013 15.9 0.0 0.04 14.3 0.0 1.9 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Mpv17_PMP22 PF04117.12 KOO30563.1 - 6.7e-17 61.5 1.4 1e-16 60.9 1.4 1.3 1 0 0 1 1 1 1 Mpv17 / PMP22 family zf-CCHC PF00098.23 KOO30564.1 - 0.00047 20.1 10.4 0.00057 19.8 3.6 3.0 2 1 0 2 2 2 1 Zinc knuckle zf-CCCH_4 PF18044.1 KOO30564.1 - 0.017 14.9 1.3 0.017 14.9 1.3 2.1 2 0 0 2 2 2 0 CCCH-type zinc finger zf-CCHC_5 PF14787.6 KOO30564.1 - 0.03 14.0 1.0 0.03 14.0 1.0 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 KOO30564.1 - 0.034 14.0 0.5 0.034 14.0 0.5 2.8 3 0 0 3 3 3 0 Zinc knuckle GLTP PF08718.11 KOO30565.1 - 1.5e-12 48.1 0.0 2.2e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) ELYS PF13934.6 KOO30566.1 - 0.066 13.2 0.2 0.13 12.2 0.1 1.3 1 1 0 1 1 1 0 Nuclear pore complex assembly Lectin_C PF00059.21 KOO30568.1 - 1.6e-05 25.6 0.4 4.8e-05 24.0 0.4 1.9 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 KOO30568.1 - 0.00014 21.6 0.2 0.023 14.3 0.2 2.5 2 0 0 2 2 2 2 UL45 protein, carbohydrate-binding C-type lectin-like WW PF00397.26 KOO30568.1 - 0.011 15.9 4.2 0.016 15.3 0.8 2.4 2 0 0 2 2 2 0 WW domain Ank_2 PF12796.7 KOO30569.1 - 1.9e-12 47.6 0.0 6.5e-12 45.9 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO30569.1 - 2e-10 41.0 0.3 1e-08 35.5 0.0 3.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO30569.1 - 7.3e-09 35.7 0.4 0.0001 22.5 0.1 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO30569.1 - 1.2e-07 31.9 0.0 0.0053 17.1 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KOO30569.1 - 5.5e-06 26.3 0.0 0.11 13.1 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ion_trans PF00520.31 KOO30569.1 - 7.9e-05 22.0 0.1 0.00015 21.1 0.1 1.4 1 0 0 1 1 1 1 Ion transport protein LRR_6 PF13516.6 KOO30570.1 - 6.1e-17 60.2 10.5 0.0017 18.3 0.2 5.7 5 0 0 5 5 5 4 Leucine Rich repeat NACHT PF05729.12 KOO30570.1 - 1.6e-05 24.9 0.4 7.5e-05 22.7 0.0 2.2 2 0 0 2 2 2 1 NACHT domain RRM_1 PF00076.22 KOO30570.1 - 0.045 13.6 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_4 PF12799.7 KOO30570.1 - 1.2 9.7 3.2 27 5.4 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) ABC1 PF03109.16 KOO30572.1 - 1e-20 74.0 0.0 1.6e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO30572.1 - 0.0002 21.4 2.4 0.0002 21.4 2.4 3.7 2 2 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO30572.1 - 0.0036 16.7 0.0 0.0074 15.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TPR_2 PF07719.17 KOO30573.1 - 3.1e-05 23.8 2.0 0.017 15.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO30573.1 - 0.0023 17.7 1.5 0.02 14.7 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_5 PF12688.7 KOO30573.1 - 0.01 16.1 0.1 0.02 15.1 0.1 1.5 1 0 0 1 1 1 0 Tetratrico peptide repeat TPR_19 PF14559.6 KOO30573.1 - 0.024 15.1 0.7 0.024 15.1 0.7 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO30573.1 - 0.054 13.5 0.0 1.5 9.0 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30573.1 - 0.14 13.1 4.0 10 7.3 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_transf_11 PF01531.16 KOO30575.1 - 0.17 11.1 0.4 1.1 8.4 0.3 2.1 1 1 0 1 1 1 0 Glycosyl transferase family 11 ANAPC15 PF15243.6 KOO30576.1 - 6.2e-08 32.9 10.6 1.4e-07 31.8 10.6 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 15 NOA36 PF06524.12 KOO30576.1 - 1.3 8.2 12.0 1.5 8.0 12.0 1.0 1 0 0 1 1 1 0 NOA36 protein Cytomega_UL84 PF06284.11 KOO30576.1 - 4.4 5.6 6.4 4.9 5.5 6.4 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein NeA_P2 PF12312.8 KOO30578.1 - 0.075 12.5 0.2 0.12 11.8 0.2 1.3 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein Myosin_head PF00063.21 KOO30579.1 - 1.4e-89 301.1 0.0 1.1e-57 195.7 0.0 3.9 2 1 1 3 3 3 2 Myosin head (motor domain) AAA_16 PF13191.6 KOO30579.1 - 0.0031 17.9 0.8 0.024 15.0 0.4 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 KOO30579.1 - 0.022 14.5 0.5 0.06 13.1 0.5 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KOO30579.1 - 0.08 12.2 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.26 KOO30579.1 - 0.088 12.5 0.1 0.96 9.1 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain DJ-1_PfpI PF01965.24 KOO30580.1 - 1.9e-47 161.1 1.0 2.3e-47 160.9 1.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family 2OG-FeII_Oxy_3 PF13640.6 KOO30582.1 - 0.0019 19.0 0.0 0.0033 18.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily adh_short PF00106.25 KOO30583.1 - 1.4e-45 155.2 0.1 1.7e-45 154.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO30583.1 - 3.5e-27 95.5 0.7 4.7e-27 95.1 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO30583.1 - 7.7e-16 58.5 0.9 1.4e-15 57.7 0.9 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 KOO30583.1 - 2e-05 24.5 0.9 3.6e-05 23.7 0.9 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOO30583.1 - 0.00044 19.8 0.6 0.00061 19.3 0.1 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO30583.1 - 0.002 17.6 0.0 0.0035 16.8 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase THF_DHG_CYH_C PF02882.19 KOO30583.1 - 0.0059 15.9 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.6 KOO30583.1 - 0.0084 16.5 0.1 0.015 15.8 0.1 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding 3Beta_HSD PF01073.19 KOO30583.1 - 0.011 14.7 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KOO30583.1 - 0.02 14.0 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ApbA PF02558.16 KOO30583.1 - 0.029 14.0 0.1 0.044 13.4 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 KOO30583.1 - 0.14 12.8 0.1 0.29 11.7 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DFP PF04127.15 KOO30583.1 - 0.2 11.5 1.6 0.35 10.7 1.6 1.5 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein BBIP10 PF14777.6 KOO30586.1 - 4.1e-23 80.7 0.3 5e-23 80.4 0.3 1.1 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 FYVE PF01363.21 KOO30587.1 - 1.5e-16 60.3 1.1 5.4e-16 58.5 0.7 2.1 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.16 KOO30587.1 - 0.043 14.0 1.7 0.11 12.7 1.7 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger TPR_10 PF13374.6 KOO30588.1 - 1.7e-51 170.8 22.0 8.5e-10 38.2 0.3 6.1 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.6 KOO30588.1 - 6.1e-50 167.4 35.9 3e-16 59.5 2.7 5.0 1 1 5 6 6 6 6 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO30588.1 - 7.6e-19 68.3 13.1 6e-14 52.2 6.1 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_1 PF00515.28 KOO30588.1 - 6.5e-18 63.7 4.0 0.0015 18.3 0.6 5.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_4 PF07721.14 KOO30588.1 - 1.4e-16 59.3 33.3 0.015 15.9 0.2 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOO30588.1 - 7.4e-16 56.9 11.2 0.0076 16.3 0.8 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30588.1 - 7.3e-14 50.8 3.5 0.063 13.5 0.1 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30588.1 - 1.6e-09 37.8 18.9 0.31 12.0 0.0 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO30588.1 - 3.6e-08 32.9 19.1 0.29 11.2 0.8 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO30588.1 - 4.9e-08 33.4 19.6 0.0051 17.3 2.3 4.4 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOO30588.1 - 2.6e-07 30.6 10.2 1.9 9.0 0.0 6.2 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO30588.1 - 4e-06 27.4 24.8 0.49 11.1 1.8 5.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_3 PF07720.12 KOO30588.1 - 6.7e-06 26.0 0.0 5.7 7.0 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO30588.1 - 3e-05 23.6 10.7 2.8 7.7 0.4 6.1 6 0 0 6 6 6 2 TPR repeat HisKA_3 PF07730.13 KOO30588.1 - 0.0013 19.2 11.1 0.72 10.4 0.1 5.1 4 1 1 5 5 5 1 Histidine kinase TPR_21 PF09976.9 KOO30588.1 - 0.033 13.9 1.1 20 4.8 0.0 3.6 3 1 2 5 5 5 0 Tetratricopeptide repeat-like domain Sec16_C PF12931.7 KOO30588.1 - 0.036 13.7 1.3 28 4.3 0.1 3.9 1 1 2 3 3 3 0 Sec23-binding domain of Sec16 Osmo_CC PF08946.10 KOO30588.1 - 0.078 13.2 0.0 1.8e+02 2.5 0.0 4.4 4 0 0 4 4 4 0 Osmosensory transporter coiled coil TPR_6 PF13174.6 KOO30588.1 - 0.82 10.4 16.3 18 6.2 0.1 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat tRNA-synt_1 PF00133.22 KOO30589.1 - 1.5e-33 116.0 0.1 6e-10 38.0 0.1 4.1 4 0 0 4 4 4 4 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KOO30589.1 - 1.6e-16 60.1 0.0 4.9e-08 32.1 0.0 3.3 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KOO30589.1 - 2.1e-12 47.3 0.1 4.1e-12 46.3 0.1 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA fn3 PF00041.21 KOO30589.1 - 1.3e-07 31.8 0.0 2.7e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain tRNA-synt_1e PF01406.19 KOO30589.1 - 2.1e-05 24.0 0.0 3.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 KOO30589.1 - 0.035 13.0 0.0 0.062 12.2 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) tRNA-synt_1b PF00579.25 KOO30589.1 - 0.1 11.9 0.0 0.38 10.0 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) DNA_ligase_IV PF11411.8 KOO30589.1 - 0.85 9.8 2.8 12 6.2 0.1 2.9 3 0 0 3 3 3 0 DNA ligase IV PDZ PF00595.24 KOO30590.1 - 0.18 12.2 0.2 0.41 11.0 0.2 1.6 1 0 0 1 1 1 0 PDZ domain DUF5610 PF18433.1 KOO30590.1 - 0.26 11.8 1.3 0.37 11.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5610) DUF2922 PF11148.8 KOO30591.1 - 0.64 9.8 0.1 0.64 9.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2922) Zip PF02535.22 KOO30591.1 - 8.4 5.5 13.4 11 5.1 13.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Cytidylate_kin PF02224.18 KOO30592.1 - 0.0029 17.4 0.4 0.04 13.7 0.0 2.4 2 1 0 2 2 2 1 Cytidylate kinase AAA_30 PF13604.6 KOO30592.1 - 0.0051 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO30592.1 - 0.0096 16.3 0.9 0.019 15.4 0.1 2.1 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 KOO30592.1 - 0.083 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain LRR_6 PF13516.6 KOO30593.1 - 1.5e-31 105.7 16.9 0.00019 21.2 0.1 8.9 9 0 0 9 9 9 6 Leucine Rich repeat SpoU_sub_bind PF08032.12 KOO30593.1 - 3.5e-05 24.0 2.4 0.091 13.1 0.0 3.9 3 0 0 3 3 3 2 RNA 2'-O ribose methyltransferase substrate binding Skp1 PF01466.19 KOO30593.1 - 0.00039 20.5 0.0 0.0014 18.6 0.0 2.0 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_4 PF12799.7 KOO30593.1 - 0.00078 19.8 1.5 14 6.3 0.1 5.2 3 3 1 4 4 4 1 Leucine Rich repeats (2 copies) FIST_C PF10442.9 KOO30593.1 - 0.015 15.2 2.4 1.5 8.8 0.3 2.7 1 1 1 2 2 2 0 FIST C domain CbiG_N PF11760.8 KOO30593.1 - 0.02 14.9 20.3 0.42 10.7 0.1 5.6 3 1 2 5 5 5 0 Cobalamin synthesis G N-terminal EIF_2_alpha PF07541.12 KOO30593.1 - 0.026 14.6 1.8 12 6.1 0.1 3.6 1 1 0 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit SET PF00856.28 KOO30594.1 - 6.3e-07 29.9 0.0 2e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 SET domain SAM_2 PF07647.17 KOO30595.1 - 0.11 12.6 2.1 36 4.6 0.1 2.8 1 1 2 3 3 3 0 SAM domain (Sterile alpha motif) PSI_8 PF00796.18 KOO30595.1 - 0.5 10.3 2.2 0.84 9.5 2.2 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VIII Forkhead_N PF08430.12 KOO30595.1 - 0.7 10.5 27.6 0.91 10.1 27.6 1.3 1 0 0 1 1 1 0 Forkhead N-terminal region Snf7 PF03357.21 KOO30596.1 - 2.8e-20 72.6 10.2 3.7e-20 72.2 10.2 1.1 1 0 0 1 1 1 1 Snf7 Seryl_tRNA_N PF02403.22 KOO30596.1 - 0.026 14.8 13.5 0.062 13.5 6.6 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Cullin PF00888.22 KOO30596.1 - 0.046 12.3 1.8 0.055 12.1 1.8 1.1 1 0 0 1 1 1 0 Cullin family Spc7 PF08317.11 KOO30596.1 - 0.11 11.3 5.7 0.15 10.9 5.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein SOGA PF11365.8 KOO30596.1 - 0.23 12.6 5.5 0.1 13.8 2.8 1.8 2 0 0 2 2 2 0 Protein SOGA DUF2981 PF11200.8 KOO30596.1 - 0.72 9.5 3.5 0.89 9.2 3.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2981) DSBA PF01323.20 KOO30596.1 - 3.9 7.2 8.7 1 9.1 2.5 2.2 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DivIC PF04977.15 KOO30596.1 - 9.1 6.1 9.1 3.1 7.7 3.2 2.7 3 0 0 3 3 3 0 Septum formation initiator YlqD PF11068.8 KOO30596.1 - 9.3 6.6 10.9 2.4e+02 2.1 10.9 2.3 1 1 0 1 1 1 0 YlqD protein Armet PF10208.9 KOO30597.1 - 2.3e-32 111.9 2.3 2.9e-32 111.6 2.3 1.0 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding SAP PF02037.27 KOO30597.1 - 0.0031 17.2 0.0 0.0081 15.9 0.0 1.7 1 0 0 1 1 1 1 SAP domain Slx4 PF09494.10 KOO30597.1 - 0.039 13.9 0.3 8.1 6.5 0.0 2.5 2 0 0 2 2 2 0 Slx4 endonuclease NUFIP2 PF15293.6 KOO30597.1 - 0.12 11.2 0.8 0.15 10.9 0.8 1.1 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 LRR_8 PF13855.6 KOO30598.1 - 2.3e-07 30.5 2.2 3.5e-07 29.9 0.2 2.1 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 KOO30598.1 - 2.3e-07 31.0 1.0 7.3e-05 23.1 0.0 2.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) DUF5362 PF17319.2 KOO30598.1 - 0.29 11.0 0.8 0.87 9.5 0.8 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5362) PTPlike_phytase PF14566.6 KOO30599.1 - 1.4e-27 96.7 0.0 2.3e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate TPR_2 PF07719.17 KOO30600.1 - 0.0037 17.3 13.5 0.047 13.8 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat GCIP PF13324.6 KOO30600.1 - 0.071 12.7 1.4 0.11 12.0 1.4 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting TPR_1 PF00515.28 KOO30600.1 - 0.076 12.9 6.9 1.2 9.0 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30600.1 - 0.18 12.1 2.9 29 5.2 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat SNARE PF05739.19 KOO30603.1 - 6.7e-13 48.4 0.6 2e-11 43.7 0.0 2.5 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 KOO30603.1 - 0.00018 21.3 8.8 0.041 13.6 4.7 2.5 2 1 1 3 3 3 2 Syntaxin Collagen_mid PF15984.5 KOO30603.1 - 0.00081 19.2 1.2 0.0041 16.9 0.1 2.1 2 0 0 2 2 2 1 Bacterial collagen, middle region Syntaxin-18_N PF10496.9 KOO30603.1 - 0.0065 16.7 2.6 0.41 10.9 0.0 2.8 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus EzrA PF06160.12 KOO30603.1 - 0.016 13.4 7.2 0.014 13.6 2.4 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA HisKA_4TM PF16926.5 KOO30603.1 - 0.025 14.1 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 Archaeal 4TM region of histidine kinase Cep3 PF16846.5 KOO30603.1 - 0.03 12.8 0.2 0.052 12.0 0.2 1.3 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B Baculo_PEP_C PF04513.12 KOO30603.1 - 0.034 14.2 9.1 0.31 11.1 0.7 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cluap1 PF10234.9 KOO30603.1 - 0.065 12.6 9.3 0.02 14.3 5.3 1.9 2 0 0 2 2 2 0 Clusterin-associated protein-1 DUF16 PF01519.16 KOO30603.1 - 0.07 13.6 0.4 0.07 13.6 0.4 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 Rx_N PF18052.1 KOO30603.1 - 0.13 12.5 2.1 1.7 9.0 0.6 2.3 2 0 0 2 2 2 0 Rx N-terminal domain SKA1 PF07160.12 KOO30603.1 - 0.2 11.5 8.2 0.39 10.5 0.4 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Tup_N PF08581.10 KOO30603.1 - 0.26 11.6 3.5 4 7.8 0.2 2.9 2 2 0 2 2 2 0 Tup N-terminal Apolipoprotein PF01442.18 KOO30603.1 - 0.33 10.8 9.7 5 7.0 4.6 2.4 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain Syntaxin-6_N PF09177.11 KOO30603.1 - 0.48 11.0 4.5 1.3 9.7 0.9 2.9 2 2 1 3 3 3 0 Syntaxin 6, N-terminal ABC_tran_CTD PF16326.5 KOO30603.1 - 0.78 10.0 4.1 0.89 9.9 1.3 2.5 2 1 0 2 2 2 0 ABC transporter C-terminal domain CdvA PF18822.1 KOO30603.1 - 0.99 9.2 5.3 0.92 9.3 2.2 2.3 2 1 0 2 2 2 0 CdvA-like coiled-coil domain Allexi_40kDa PF05549.11 KOO30603.1 - 1.4 8.4 8.8 1.9 7.9 4.0 2.3 2 1 0 2 2 2 0 Allexivirus 40kDa protein DUF1664 PF07889.12 KOO30603.1 - 2 8.5 6.3 4.3 7.4 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 KOO30603.1 - 2.6 6.8 11.0 2.5 6.9 0.6 2.4 2 1 0 2 2 2 0 Spc7 kinetochore protein DEAD PF00270.29 KOO30604.1 - 0.022 14.5 0.0 0.32 10.8 0.0 2.7 3 0 0 3 3 3 0 DEAD/DEAH box helicase XK-related PF09815.9 KOO30605.1 - 0.00038 19.6 0.1 0.0011 18.1 0.1 1.7 1 1 0 1 1 1 1 XK-related protein zf-PARP PF00645.18 KOO30605.1 - 0.033 15.0 0.0 0.069 14.0 0.0 1.5 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Ank_2 PF12796.7 KOO30606.1 - 1.2e-20 73.9 0.0 1.2e-09 38.6 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO30606.1 - 4.2e-14 52.7 1.6 1.3e-10 41.6 0.0 3.5 3 1 1 4 4 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO30606.1 - 1.1e-11 44.6 2.0 4.1e-06 27.0 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO30606.1 - 1.7e-11 43.3 0.6 0.00016 21.8 0.0 4.7 4 1 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOO30606.1 - 2.1e-10 40.6 1.7 2.4e-05 24.5 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) TPR_2 PF07719.17 KOO30606.1 - 9.8e-06 25.3 11.9 0.00076 19.4 0.3 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO30606.1 - 0.03 14.1 0.1 0.03 14.1 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO30606.1 - 0.044 13.8 1.4 1.8 8.8 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO30606.1 - 0.049 14.1 8.1 0.15 12.6 8.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO30606.1 - 0.055 14.1 20.1 0.42 11.3 3.7 3.3 3 0 0 3 3 2 0 Tetratricopeptide repeat BTAD PF03704.17 KOO30606.1 - 0.52 10.7 10.8 0.98 9.8 8.3 2.9 3 1 0 3 3 3 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 KOO30606.1 - 1.2 10.0 3.8 3.8 8.3 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30606.1 - 1.2 10.2 13.3 5.1 8.2 2.6 3.6 2 0 0 2 2 2 0 Tetratricopeptide repeat PolyA_pol PF01743.20 KOO30607.1 - 7.6e-11 42.5 0.3 2.3e-08 34.5 0.3 3.1 2 1 0 2 2 2 2 Poly A polymerase head domain LRR_6 PF13516.6 KOO30610.1 - 4.5e-23 79.3 15.1 0.0028 17.6 0.1 8.8 9 0 0 9 9 9 7 Leucine Rich repeat LRR_4 PF12799.7 KOO30610.1 - 1.9e-11 44.0 2.0 0.034 14.6 0.0 5.5 6 0 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO30610.1 - 1.6e-07 30.9 0.1 8.3 7.4 0.1 6.9 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO30610.1 - 3.9e-05 23.3 10.0 4.9 7.0 0.5 6.7 6 2 0 6 6 6 3 Leucine rich repeat YusW PF14039.6 KOO30610.1 - 0.0031 18.0 0.0 26 5.4 0.0 3.3 3 0 0 3 3 3 0 YusW-like protein SpoU_sub_bind PF08032.12 KOO30610.1 - 0.039 14.2 0.1 20 5.6 0.0 3.0 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding DUF2202 PF09968.9 KOO30610.1 - 0.072 12.9 0.2 14 5.4 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized protein domain (DUF2202) SQS_PSY PF00494.19 KOO30611.1 - 7.2e-71 238.8 0.2 9.5e-71 238.4 0.2 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase DUF1386 PF07138.11 KOO30611.1 - 0.0024 17.2 0.0 0.0034 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1386) Beach PF02138.18 KOO30612.1 - 1.6e-118 395.1 0.0 2.2e-118 394.7 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain DUF4704 PF15787.5 KOO30612.1 - 5.4e-22 78.3 1.5 1e-09 38.0 0.0 3.5 2 2 1 3 3 3 2 Domain of unknown function (DUF4704) PH_BEACH PF14844.6 KOO30612.1 - 1.6e-19 69.9 0.0 2.6e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 KOO30612.1 - 4.3e-15 55.8 2.5 3.3e-05 24.6 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat DUF4800 PF16057.5 KOO30612.1 - 3.2e-05 23.3 7.4 6.9e-05 22.2 7.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) Laminin_G_3 PF13385.6 KOO30612.1 - 7.5e-05 22.9 0.0 0.026 14.7 0.0 2.5 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily DUF1088 PF06469.11 KOO30612.1 - 0.0021 17.8 5.0 0.004 16.8 5.0 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) tRNA-synt_1d PF00750.19 KOO30613.1 - 3.4e-113 378.1 0.0 1.3e-112 376.2 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 KOO30613.1 - 1.5e-25 89.7 0.0 4.2e-25 88.2 0.0 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 KOO30613.1 - 1.7e-11 44.5 0.1 4.1e-11 43.3 0.1 1.7 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 KOO30613.1 - 0.0093 15.3 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.22 KOO30613.1 - 0.027 12.7 0.0 0.042 12.1 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KOO30613.1 - 0.091 11.5 0.0 0.14 10.8 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (M) SapB_2 PF03489.17 KOO30613.1 - 0.59 10.3 1.9 0.97 9.6 0.2 2.4 2 0 0 2 2 2 0 Saposin-like type B, region 2 DUF2828 PF11443.8 KOO30614.1 - 1.4e-48 165.5 0.8 4.7e-20 71.2 0.0 4.7 2 2 2 4 4 4 4 Domain of unknown function (DUF2828) VWA_CoxE PF05762.14 KOO30614.1 - 1.2e-05 24.8 0.1 3.3e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein RRM_1 PF00076.22 KOO30615.1 - 9.3e-37 124.7 0.5 7.4e-18 64.1 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOO30615.1 - 7.4e-08 32.0 0.0 0.0027 17.3 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 KOO30615.1 - 7.2e-07 30.2 0.3 3.3e-06 28.1 0.3 2.1 1 1 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 KOO30615.1 - 0.0051 16.7 0.0 0.68 9.8 0.0 3.1 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_3 PF08777.11 KOO30615.1 - 0.013 15.5 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 RNA binding motif Limkain-b1 PF11608.8 KOO30615.1 - 0.096 12.8 0.1 0.63 10.2 0.1 2.4 3 0 0 3 3 3 0 Limkain b1 UBX PF00789.20 KOO30616.1 - 3.9e-06 27.0 0.0 3.4e-05 24.0 0.0 2.2 1 1 0 1 1 1 1 UBX domain Bac_small_YrzI PF09501.10 KOO30616.1 - 0.023 14.8 0.8 0.05 13.7 0.8 1.6 1 0 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) DRMBL PF07522.14 KOO30618.1 - 0.094 12.9 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase Pyrophosphatase PF00719.19 KOO30619.1 - 9.7e-37 126.2 0.0 1.2e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Phos_pyr_kin PF08543.12 KOO30620.1 - 3.3e-10 39.8 0.0 4.4e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 KOO30620.1 - 1.1e-05 25.0 0.0 1.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase NACHT PF05729.12 KOO30621.1 - 0.0001 22.3 0.1 0.00023 21.2 0.1 1.6 1 0 0 1 1 1 1 NACHT domain PHD PF00628.29 KOO30622.1 - 3.3e-10 39.7 4.6 5.6e-10 39.0 4.6 1.4 1 0 0 1 1 1 1 PHD-finger zf-RING-like PF08746.11 KOO30622.1 - 0.012 15.9 0.7 0.029 14.7 0.7 1.6 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 KOO30622.1 - 0.013 15.6 5.6 0.076 13.2 5.6 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-HC5HC2H PF13771.6 KOO30622.1 - 0.067 13.5 1.5 0.11 12.7 1.5 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain DZR PF12773.7 KOO30622.1 - 1.4 9.0 5.2 15 5.7 5.2 2.3 1 1 0 1 1 1 0 Double zinc ribbon ABC_membrane PF00664.23 KOO30624.1 - 0.00016 21.4 0.1 0.00027 20.7 0.1 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region Pkinase PF00069.25 KOO30625.1 - 2.1e-28 99.4 0.0 2.3e-28 99.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30625.1 - 1.4e-12 47.4 0.0 1.6e-12 47.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO30625.1 - 3e-05 23.5 0.1 5e-05 22.8 0.1 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO30625.1 - 0.00012 21.0 0.0 0.00014 20.7 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Inhibitor_Mig-6 PF11555.8 KOO30625.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 EGFR receptor inhibitor Mig-6 CENP-Q PF13094.6 KOO30626.1 - 0.00021 21.6 8.8 0.00024 21.3 8.8 1.1 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF1640 PF07798.11 KOO30626.1 - 0.00025 21.2 5.2 0.00029 20.9 5.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) CDC37_N PF03234.14 KOO30626.1 - 0.021 15.8 3.7 0.026 15.5 3.7 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Borrelia_P83 PF05262.11 KOO30626.1 - 0.41 9.1 6.3 0.45 8.9 6.3 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein FUSC PF04632.12 KOO30626.1 - 0.7 8.4 12.5 0.82 8.1 12.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family OmpH PF03938.14 KOO30626.1 - 0.71 10.2 11.7 0.86 9.9 11.7 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 KOO30626.1 - 1.1 8.5 3.7 1.3 8.2 3.7 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 KOO30626.1 - 1.5 8.1 11.9 1.7 8.0 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Uso1_p115_C PF04871.13 KOO30626.1 - 4.3 7.7 14.8 3.6 8.0 13.2 1.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Macoilin PF09726.9 KOO30626.1 - 7.5 5.0 12.7 8.9 4.7 12.7 1.0 1 0 0 1 1 1 0 Macoilin family MMtag PF10159.9 KOO30627.1 - 1.9e-30 105.0 3.9 4e-30 103.9 3.9 1.6 1 0 0 1 1 1 1 Multiple myeloma tumor-associated Drc1-Sld2 PF11719.8 KOO30628.1 - 0.0086 15.7 0.5 0.0086 15.7 0.5 1.1 1 0 0 1 1 1 1 DNA replication and checkpoint protein TOH_N PF12549.8 KOO30628.1 - 7.5 6.5 6.8 32 4.5 0.3 3.1 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal MMPL PF03176.15 KOO30629.1 - 6.2e-49 166.7 27.1 2e-28 99.3 6.6 2.9 2 1 0 2 2 2 2 MMPL family LSM PF01423.22 KOO30631.1 - 1.9e-20 72.3 0.5 2.5e-20 72.0 0.5 1.2 1 0 0 1 1 1 1 LSM domain Prefoldin_2 PF01920.20 KOO30631.1 - 0.069 13.1 0.3 0.11 12.4 0.3 1.4 1 0 0 1 1 1 0 Prefoldin subunit DUF150_C PF17384.2 KOO30631.1 - 0.079 13.1 0.8 0.18 12.0 0.8 1.6 1 1 0 1 1 1 0 RimP C-terminal SH3 domain Peptidase_C2 PF00648.21 KOO30633.1 - 3e-64 216.9 0.1 2.9e-63 213.7 0.0 2.1 2 0 0 2 2 2 1 Calpain family cysteine protease UIM PF02809.20 KOO30633.1 - 1.7e-07 30.6 22.6 0.0016 18.2 1.5 4.4 3 0 0 3 3 3 2 Ubiquitin interaction motif zf-Sec23_Sec24 PF04810.15 KOO30633.1 - 0.00024 21.1 0.1 0.048 13.7 0.0 2.6 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger CDC37_N PF03234.14 KOO30633.1 - 0.19 12.7 1.5 0.42 11.5 1.5 1.7 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Type_III_YscX PF09474.10 KOO30633.1 - 0.62 10.4 6.7 6.4 7.1 1.1 2.7 1 1 1 2 2 2 0 Type III secretion system YscX (type_III_YscX) MTBP_C PF14920.6 KOO30633.1 - 0.67 9.7 4.2 1.1 8.9 4.2 1.3 1 0 0 1 1 1 0 MDM2-binding LRR_8 PF13855.6 KOO30633.1 - 0.9 9.3 5.1 11 5.8 2.3 2.8 1 1 1 2 2 2 0 Leucine rich repeat Proteasome PF00227.26 KOO30634.1 - 2.5e-47 160.8 0.3 3.4e-47 160.4 0.3 1.2 1 0 0 1 1 1 1 Proteasome subunit p25-alpha PF05517.12 KOO30635.1 - 3.6e-07 30.5 0.0 7.1e-06 26.3 0.0 2.4 2 1 0 2 2 2 1 p25-alpha MiaE_2 PF13794.6 KOO30635.1 - 0.038 13.7 2.8 0.79 9.4 0.2 2.6 3 0 0 3 3 3 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like DUF1863 PF08937.11 KOO30636.1 - 0.075 13.3 0.0 0.79 10.0 0.0 2.5 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) QH-AmDH_gamma PF08992.11 KOO30638.1 - 0.024 14.6 1.1 3.3 7.8 0.0 3.1 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, gamma subunit Aldedh PF00171.22 KOO30640.1 - 2.9e-11 42.6 0.0 2.2e-10 39.6 0.0 2.4 1 1 0 1 1 1 1 Aldehyde dehydrogenase family DcuC PF03606.15 KOO30640.1 - 0.017 13.6 0.1 0.025 13.1 0.1 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Acetyltransf_1 PF00583.25 KOO30641.1 - 0.007 16.6 0.0 0.0098 16.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO30641.1 - 0.032 14.6 0.0 0.058 13.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO30641.1 - 0.041 13.8 0.0 0.064 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Kinesin PF00225.23 KOO30643.1 - 0.0059 15.6 0.0 0.008 15.1 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain UCH PF00443.29 KOO30644.1 - 5.7e-13 49.0 0.0 7.4e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO30644.1 - 0.00025 20.7 0.0 0.00029 20.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C2H2 PF00096.26 KOO30644.1 - 0.29 11.7 4.4 2.2 8.9 0.4 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2HC_2 PF13913.6 KOO30644.1 - 3 7.8 6.1 1.6 8.7 2.8 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Glyco_hydro_32C PF08244.12 KOO30645.1 - 0.0026 17.7 0.0 0.0042 17.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal RNA_pol_A_CTD PF03118.15 KOO30646.1 - 0.082 12.7 1.0 3.5 7.4 0.0 3.2 3 0 0 3 3 3 0 Bacterial RNA polymerase, alpha chain C terminal domain Baculo_PEP_C PF04513.12 KOO30646.1 - 1.3 9.0 4.4 2.4 8.2 1.0 2.8 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PhoR PF11808.8 KOO30647.1 - 0.0092 16.4 0.6 0.013 15.9 0.6 1.3 1 0 0 1 1 1 1 Phosphate regulon sensor protein PhoR UPF0242 PF06785.11 KOO30647.1 - 0.21 11.7 0.0 0.21 11.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus MtrF PF09472.10 KOO30647.1 - 4.2 6.8 5.4 1.5 8.3 2.3 1.8 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Myb_DNA-binding PF00249.31 KOO30648.1 - 2.5e-05 24.4 0.0 5.1e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO30648.1 - 0.0013 18.9 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Chromo PF00385.24 KOO30648.1 - 0.027 14.4 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Glyco_hydro_16 PF00722.21 KOO30649.1 - 5.6e-09 35.7 0.1 0.0034 16.9 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 16 SKN1 PF03935.15 KOO30649.1 - 0.0028 16.1 6.8 0.02 13.4 0.0 2.8 3 0 0 3 3 3 2 Beta-glucan synthesis-associated protein (SKN1) DUF3357 PF11837.8 KOO30649.1 - 0.057 13.9 0.9 0.1 13.1 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) SNF2_N PF00176.23 KOO30650.1 - 9.4e-11 41.0 0.0 1.6e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 KOO30650.1 - 7.3e-07 29.3 0.0 1.8e-06 28.1 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO30650.1 - 2.6e-06 27.3 0.0 4.8e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Cucumo_coat PF00760.18 KOO30652.1 - 0.025 14.3 0.1 0.051 13.2 0.1 1.5 1 0 0 1 1 1 0 Cucumovirus coat protein Sulfate_transp PF00916.20 KOO30654.1 - 2.4e-09 36.4 1.2 2.4e-09 36.4 1.2 2.3 2 1 0 2 2 2 1 Sulfate permease family Nup35_RRM PF05172.13 KOO30654.1 - 6.3e-07 29.3 0.0 3.2e-06 27.0 0.0 2.0 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 KOO30654.1 - 0.0053 16.7 0.0 0.013 15.5 0.0 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif GPI-anchored PF10342.9 KOO30655.1 - 3e-10 40.7 0.0 6.6e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family EGF_2 PF07974.13 KOO30655.1 - 0.0022 18.3 11.0 0.0022 18.3 11.0 8.5 8 0 0 8 8 8 4 EGF-like domain Pkinase PF00069.25 KOO30656.1 - 1e-39 136.5 0.0 2.1e-39 135.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30656.1 - 1.7e-25 89.8 0.0 3.9e-25 88.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase IPK PF03770.16 KOO30656.1 - 3.5e-08 33.6 0.0 6.5e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase Kinase-like PF14531.6 KOO30656.1 - 4.9e-05 22.8 0.0 8.2e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 KOO30656.1 - 0.01 15.5 0.0 1.9 8.1 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KOO30656.1 - 0.011 15.7 0.0 0.054 13.4 0.0 2.2 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO30656.1 - 0.025 13.4 0.0 0.039 12.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase KH_1 PF00013.29 KOO30657.1 - 2.6e-54 180.9 18.2 5.4e-15 55.0 0.8 5.2 5 0 0 5 5 5 4 KH domain KH_4 PF13083.6 KOO30657.1 - 7.7e-17 60.9 10.5 0.00062 19.6 0.4 4.7 4 0 0 4 4 4 4 KH domain KH_2 PF07650.17 KOO30657.1 - 2.1e-11 43.5 13.6 0.012 15.4 0.9 4.6 3 1 0 4 4 4 4 KH domain KH_5 PF13184.6 KOO30657.1 - 7.4e-06 26.0 16.5 0.69 10.0 0.6 4.7 4 1 0 4 4 4 4 NusA-like KH domain MOEP19 PF16005.5 KOO30657.1 - 0.0037 17.2 0.0 2.9 7.9 0.0 3.9 4 0 0 4 4 4 1 KH-like RNA-binding domain SLS PF14611.6 KOO30657.1 - 0.0055 16.6 2.1 0.14 12.0 0.1 3.2 3 1 0 4 4 4 1 Mitochondrial inner-membrane-bound regulator DUF5300 PF17224.3 KOO30657.1 - 0.0096 16.2 0.8 0.92 9.8 0.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF5300) Diacid_rec PF05651.13 KOO30657.1 - 0.0099 15.5 0.2 3.7 7.2 0.0 2.6 2 0 0 2 2 2 2 Putative sugar diacid recognition BMC PF00936.19 KOO30657.1 - 0.054 13.5 1.3 4.2 7.4 0.1 2.9 2 0 0 2 2 2 0 BMC domain Arg_repressor PF01316.21 KOO30657.1 - 0.058 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain EFG_C PF00679.24 KOO30657.1 - 0.19 11.8 1.1 87 3.3 0.0 3.8 3 1 0 3 3 3 0 Elongation factor G C-terminus MscS_porin PF12795.7 KOO30658.1 - 0.0012 18.5 13.8 0.0014 18.2 13.8 1.0 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain SCAN PF02023.17 KOO30658.1 - 0.006 16.4 3.8 0.01 15.6 3.3 1.7 2 0 0 2 2 2 1 SCAN domain Pkinase PF00069.25 KOO30659.1 - 1.8e-44 152.1 0.0 2.5e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30659.1 - 1.3e-38 132.8 0.0 2.2e-38 132.1 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO30659.1 - 0.00028 19.8 0.0 0.00047 19.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO30659.1 - 0.003 16.9 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like V-SNARE PF05008.15 KOO30660.1 - 2.4e-13 50.3 4.3 2.4e-13 50.3 4.3 1.8 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 KOO30660.1 - 6.1e-13 48.9 4.6 1.7e-12 47.4 4.6 1.9 1 1 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus PAS PF00989.25 KOO30661.1 - 7.7e-160 522.0 6.0 1.1e-24 86.6 0.0 8.5 8 0 0 8 8 8 7 PAS fold PAS_9 PF13426.7 KOO30661.1 - 1.1e-91 301.9 16.5 1.3e-15 57.6 0.1 8.4 8 0 0 8 8 8 7 PAS domain PAS_4 PF08448.10 KOO30661.1 - 2.3e-85 282.1 1.5 3.9e-13 49.6 0.0 8.7 8 0 0 8 8 8 8 PAS fold PAS_3 PF08447.12 KOO30661.1 - 2.6e-50 168.7 0.0 1.1e-08 35.2 0.0 7.5 7 0 0 7 7 7 7 PAS fold PAS_8 PF13188.7 KOO30661.1 - 1.4e-39 133.5 6.7 7.8e-06 25.8 0.0 7.7 7 0 0 7 7 7 7 PAS domain HATPase_c PF02518.26 KOO30661.1 - 5.1e-27 94.6 0.0 1.6e-26 93.0 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOO30661.1 - 2e-21 76.3 0.0 4.7e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain PAS_10 PF13596.6 KOO30661.1 - 3.6e-17 62.9 3.8 2.9e-05 24.6 0.0 7.4 7 0 0 7 7 7 2 PAS domain HisKA PF00512.25 KOO30661.1 - 3.6e-17 62.1 2.7 6.8e-17 61.3 0.0 3.2 3 0 0 3 3 2 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 KOO30661.1 - 1.9e-15 56.9 12.1 1.6e-06 28.3 0.1 4.5 3 0 0 3 3 3 3 Hpt domain PAS_7 PF12860.7 KOO30661.1 - 1.2e-07 31.9 3.8 2 8.6 0.0 8.0 8 1 0 8 8 7 2 PAS fold PEP-utilizers_C PF02896.18 KOO30661.1 - 0.0092 15.1 5.5 19 4.2 0.0 5.9 7 0 0 7 7 7 0 PEP-utilising enzyme, TIM barrel domain dCache_1 PF02743.18 KOO30661.1 - 0.11 12.3 4.8 14 5.4 0.0 4.4 4 1 1 5 5 5 0 Cache domain DUF1824 PF08854.10 KOO30661.1 - 0.5 10.3 2.7 1.3e+02 2.5 0.0 4.9 6 0 0 6 6 6 0 Domain of unknown function (DUF1824) TBP PF00352.21 KOO30662.1 - 4.2e-70 231.7 0.1 3.4e-35 119.8 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 KOO30662.1 - 8.9e-07 28.9 0.0 0.012 15.7 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 KOO30662.1 - 0.017 14.9 0.1 0.13 12.1 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) Fer4_19 PF06902.11 KOO30663.1 - 0.15 12.1 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Divergent 4Fe-4S mono-cluster His_Phos_2 PF00328.22 KOO30664.1 - 0.036 13.4 0.0 7.1 5.9 0.1 2.6 2 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) DUF4148 PF13663.6 KOO30664.1 - 0.18 12.0 1.7 0.49 10.6 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Choline_transpo PF04515.12 KOO30665.1 - 7.9e-52 176.5 41.3 7.9e-52 176.5 41.3 2.3 3 0 0 3 3 3 1 Plasma-membrane choline transporter EGF_2 PF07974.13 KOO30665.1 - 0.21 12.0 125.8 0.052 13.9 12.7 7.9 8 0 0 8 8 8 0 EGF-like domain DUF4381 PF14316.6 KOO30665.1 - 1.7 8.9 5.7 1.8 8.8 0.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) ShK PF01549.24 KOO30666.1 - 2.8e-51 171.7 75.6 6.3e-11 42.6 6.9 6.1 6 0 0 6 6 6 6 ShK domain-like zf-CCCH PF00642.24 KOO30666.1 - 0.0037 17.1 4.9 5.1 7.1 0.2 5.4 5 0 0 5 5 5 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF1126 PF06565.12 KOO30667.1 - 0.0015 18.4 0.0 0.0079 16.0 0.0 2.1 1 1 0 1 1 1 1 DUF1126 PH-like domain IQ PF00612.27 KOO30667.1 - 0.0027 17.3 4.3 0.98 9.4 0.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif GTP-bdg_M PF16360.5 KOO30667.1 - 0.023 15.3 0.1 0.075 13.6 0.1 1.8 1 0 0 1 1 1 0 GTP-binding GTPase Middle Region TSKS PF15358.6 KOO30668.1 - 0.00044 18.8 1.8 0.00046 18.7 1.8 1.0 1 0 0 1 1 1 1 Testis-specific serine kinase substrate CENP-F_leu_zip PF10473.9 KOO30668.1 - 0.00093 19.2 9.3 0.0013 18.8 7.0 1.8 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tab2_like PF06485.11 KOO30668.1 - 0.012 15.1 1.4 0.014 14.9 1.4 1.0 1 0 0 1 1 1 0 RNA-binding protein Tab2/Atab2 SOAR PF16533.5 KOO30668.1 - 0.46 10.5 7.9 0.59 10.1 4.6 2.3 1 1 1 2 2 2 0 STIM1 Orai1-activating region COG2 PF06148.11 KOO30668.1 - 4.4 7.4 8.5 9.6 6.3 4.5 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Glyco_hydro_38N PF01074.22 KOO30669.1 - 7.1e-83 278.3 1.7 9.5e-83 277.9 1.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 KOO30669.1 - 4.7e-39 134.7 0.0 8.4e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro38C2 PF17677.1 KOO30669.1 - 0.00013 22.0 0.0 0.00031 20.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Flagellin_IN PF07196.13 KOO30669.1 - 0.28 11.4 1.2 0.38 11.0 0.1 1.8 2 0 0 2 2 2 0 Flagellin hook IN motif EF-hand_6 PF13405.6 KOO30670.1 - 4.5e-18 63.6 0.4 0.00014 21.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO30670.1 - 6.3e-17 61.8 0.0 4e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO30670.1 - 1.3e-15 55.6 0.0 4.3e-05 22.7 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 KOO30670.1 - 8.7e-12 44.0 0.1 0.00069 19.0 0.0 4.4 4 0 0 4 4 4 2 EF hand GPS PF01825.21 KOO30670.1 - 3.3e-08 33.9 3.6 3.3e-08 33.9 3.6 2.0 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif EF-hand_9 PF14658.6 KOO30670.1 - 0.022 15.1 0.0 6 7.3 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.6 KOO30670.1 - 0.13 12.1 0.0 31 4.5 0.0 2.9 2 1 1 3 3 3 0 EF-hand domain pair HEPN_LA2681 PF18733.1 KOO30670.1 - 0.26 10.5 0.1 14 4.9 0.0 2.2 1 1 1 2 2 2 0 LA2681-like HEPN SAP PF02037.27 KOO30670.1 - 0.49 10.2 3.7 38 4.2 0.1 3.3 3 0 0 3 3 3 0 SAP domain Antimicrobial13 PF08108.11 KOO30670.1 - 9.4 6.5 9.4 28 5.0 1.4 2.9 2 0 0 2 2 2 0 Halocidin family Beach PF02138.18 KOO30671.1 - 2.1e-88 296.3 0.0 2.9e-88 295.9 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain VPS9 PF02204.18 KOO30671.1 - 9e-14 51.6 0.0 1.6e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain PH_BEACH PF14844.6 KOO30671.1 - 2.6e-05 24.2 0.1 9.5e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH IQ PF00612.27 KOO30671.1 - 0.033 14.0 0.0 0.079 12.8 0.0 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif COPIIcoated_ERV PF07970.12 KOO30672.1 - 4e-24 85.7 0.1 6.9e-24 84.9 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOO30672.1 - 7.3e-16 58.3 0.0 1.3e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.20 KOO30672.1 - 4.3e-12 45.9 0.0 1e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin ShK PF01549.24 KOO30672.1 - 3.9e-07 30.5 10.7 0.0035 17.8 2.0 2.4 2 0 0 2 2 2 2 ShK domain-like GAGA_bind PF06217.12 KOO30672.1 - 0.16 12.2 2.8 0.26 11.5 2.8 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DUF5427 PF10310.9 KOO30672.1 - 2.7 6.9 12.3 4.1 6.3 12.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) PAT1 PF09770.9 KOO30672.1 - 6.2 5.0 15.7 11 4.1 15.7 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.12 KOO30672.1 - 7.4 6.3 11.6 14 5.4 11.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GSH-S_N PF02951.14 KOO30673.1 - 0.53 10.4 3.8 20 5.3 0.1 4.3 4 0 0 4 4 4 0 Prokaryotic glutathione synthetase, N-terminal domain PI_PP_I PF18363.1 KOO30673.1 - 5.3 7.3 7.6 71 3.7 0.4 4.5 4 0 0 4 4 4 0 Phosphoinositide phosphatase insertion domain GSH-S_N PF02951.14 KOO30674.1 - 0.1 12.8 7.3 7.9 6.6 0.1 3.5 3 0 0 3 3 3 0 Prokaryotic glutathione synthetase, N-terminal domain DUF2396 PF09654.10 KOO30674.1 - 0.43 10.7 12.0 5.9 7.0 0.9 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2396) Agenet PF05641.12 KOO30675.1 - 0.035 14.6 0.1 0.15 12.5 0.0 1.9 2 0 0 2 2 2 0 Agenet domain TUDOR_5 PF18359.1 KOO30675.1 - 0.13 11.9 0.4 0.35 10.6 0.2 1.8 2 0 0 2 2 2 0 Histone methyltransferase Tudor domain 1 AP2 PF00847.20 KOO30676.1 - 0.00083 19.5 0.9 0.003 17.7 0.4 4.7 4 1 1 5 5 5 2 AP2 domain GIT_CC PF16559.5 KOO30677.1 - 6.7 6.7 9.0 0.41 10.5 0.3 3.2 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor SecA_SW PF07516.13 KOO30678.1 - 0.016 15.3 0.1 0.021 14.9 0.1 1.2 1 0 0 1 1 1 0 SecA Wing and Scaffold domain Pyr_redox_2 PF07992.14 KOO30679.1 - 2.9e-43 148.2 0.1 4.6e-43 147.5 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOO30679.1 - 3.7e-24 85.1 0.1 9e-24 83.9 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOO30679.1 - 3.5e-16 59.5 0.4 8.3e-16 58.3 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO30679.1 - 0.0007 18.9 0.0 0.0031 16.8 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 KOO30679.1 - 0.0032 17.4 0.4 0.0062 16.4 0.1 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 KOO30679.1 - 0.01 15.2 0.0 0.022 14.1 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 KOO30679.1 - 0.022 14.0 0.2 0.046 13.0 0.2 1.5 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 KOO30679.1 - 0.026 13.3 0.2 1.1 7.9 0.0 2.9 3 1 0 3 3 3 0 HI0933-like protein XdhC_C PF13478.6 KOO30679.1 - 0.04 14.4 0.1 0.1 13.1 0.1 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain PT-VENN PF04829.13 KOO30679.1 - 0.073 13.2 1.1 2.1 8.5 0.1 2.9 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif NAD_binding_7 PF13241.6 KOO30679.1 - 0.13 12.7 0.1 0.4 11.2 0.1 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding DAO PF01266.24 KOO30679.1 - 0.18 11.3 8.5 0.19 11.3 0.1 3.2 3 1 0 4 4 4 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KOO30679.1 - 0.23 10.4 1.5 0.45 9.5 0.1 2.1 2 1 1 3 3 3 0 Lycopene cyclase protein P22_CoatProtein PF11651.8 KOO30680.1 - 0.038 12.6 0.0 0.041 12.5 0.0 1.0 1 0 0 1 1 1 0 P22 coat protein - gene protein 5 RNA_pol_Rpb2_6 PF00562.28 KOO30681.1 - 3.7e-123 411.4 0.0 6.3e-123 410.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_4 PF04566.13 KOO30681.1 - 5.6e-23 81.0 2.3 2.4e-22 79.0 0.2 2.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.14 KOO30681.1 - 1.5e-22 80.2 0.0 2.6e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 KOO30681.1 - 6.5e-20 71.1 0.6 1.6e-19 69.8 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 KOO30681.1 - 4.3e-14 52.8 0.1 1.3e-13 51.3 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_7 PF04560.20 KOO30681.1 - 4.7e-14 52.5 0.2 1.1e-13 51.3 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_1 PF04563.15 KOO30681.1 - 1.6e-13 50.6 0.0 2.4e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit CDC37_N PF03234.14 KOO30682.1 - 0.0082 17.1 10.1 0.092 13.7 0.6 2.3 2 0 0 2 2 2 2 Cdc37 N terminal kinase binding CS PF04969.16 KOO30682.1 - 0.2 12.7 0.0 0.34 12.0 0.0 1.5 1 1 0 1 1 1 0 CS domain CD52 PF15116.6 KOO30682.1 - 4.8 7.3 5.3 10 6.2 5.3 1.6 1 0 0 1 1 1 0 CAMPATH-1 antigen PP2C PF00481.21 KOO30683.1 - 1.7e-43 149.2 0.0 2.2e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO30683.1 - 0.0064 16.2 1.1 0.082 12.5 1.1 2.5 1 1 0 1 1 1 1 Protein phosphatase 2C CitG PF01874.16 KOO30683.1 - 0.13 11.9 1.7 1.6 8.3 0.3 2.6 3 0 0 3 3 3 0 ATP:dephospho-CoA triphosphoribosyl transferase Ion_trans_2 PF07885.16 KOO30684.1 - 2.1e-33 114.1 42.2 1.2e-10 41.2 0.1 5.4 6 0 0 6 6 6 4 Ion channel DUF2157 PF09925.9 KOO30684.1 - 3.9 7.3 11.1 6.9 6.5 0.1 4.5 4 2 1 5 5 5 0 Predicted membrane protein (DUF2157) IDO PF01231.18 KOO30685.1 - 2.1e-52 178.4 0.0 8e-46 156.7 0.0 3.6 2 1 0 2 2 2 2 Indoleamine 2,3-dioxygenase Cyt-b5 PF00173.28 KOO30685.1 - 4.8e-20 71.5 0.1 1.3e-19 70.1 0.1 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ion_trans_2 PF07885.16 KOO30686.1 - 3.9e-07 29.9 0.1 6.9e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 KOO30686.1 - 0.067 12.4 0.2 0.097 11.9 0.2 1.2 1 0 0 1 1 1 0 Ion transport protein Tub PF01167.18 KOO30689.1 - 4.8e-89 298.3 0.1 4.8e-89 298.3 0.1 1.7 2 0 0 2 2 2 1 Tub family DUF3527 PF12043.8 KOO30689.1 - 0.16 11.5 0.0 0.16 11.5 0.0 2.8 3 1 1 4 4 4 0 Domain of unknown function (DUF3527) Nuc_deoxyri_tr2 PF15891.5 KOO30689.1 - 1 9.7 2.8 2.8 8.3 0.6 2.6 2 1 1 3 3 3 0 Nucleoside 2-deoxyribosyltransferase like Ion_trans PF00520.31 KOO30690.1 - 1.3e-30 106.4 12.0 1.6e-30 106.2 12.0 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO30690.1 - 0.0027 16.5 15.6 0.036 12.7 8.2 3.0 2 1 0 2 2 2 2 Polycystin cation channel Prefoldin PF02996.17 KOO30691.1 - 6.2e-18 64.9 0.2 7.8e-18 64.5 0.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit ZapB PF06005.12 KOO30691.1 - 1.6 9.2 8.8 2 8.9 0.6 2.8 2 1 1 3 3 3 0 Cell division protein ZapB Methyltransf_25 PF13649.6 KOO30692.1 - 6e-17 62.1 0.0 1.1e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO30692.1 - 1.4e-16 60.9 0.0 2.5e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO30692.1 - 5.9e-13 48.7 0.0 1.6e-11 44.0 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 KOO30692.1 - 7.3e-12 45.3 0.0 1.2e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO30692.1 - 2e-11 44.5 0.0 3.1e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO30692.1 - 9.6e-07 28.8 0.0 1.8e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KOO30692.1 - 0.0047 16.9 0.0 0.0092 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOO30692.1 - 0.015 15.3 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOO30692.1 - 0.053 13.1 0.0 0.089 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain SNF2_N PF00176.23 KOO30694.1 - 6e-71 239.0 0.0 1e-70 238.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain RCC1 PF00415.18 KOO30694.1 - 1.1e-43 147.7 27.2 3.7e-09 37.0 0.0 8.3 7 2 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO30694.1 - 8.5e-27 92.4 39.7 4.6e-06 26.3 1.9 8.0 9 0 0 9 9 7 6 Regulator of chromosome condensation (RCC1) repeat Helicase_C PF00271.31 KOO30694.1 - 7.9e-19 68.0 0.0 1.5e-17 63.9 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PHD PF00628.29 KOO30694.1 - 6.4e-11 42.0 7.7 6.4e-11 42.0 7.7 3.6 3 0 0 3 3 3 2 PHD-finger ResIII PF04851.15 KOO30694.1 - 2.1e-10 40.9 0.0 4.7e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO30694.1 - 3e-08 33.6 0.0 5.6e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase TPR_11 PF13414.6 KOO30694.1 - 8e-06 25.4 2.4 0.15 11.8 0.2 3.8 4 0 0 4 4 4 2 TPR repeat TPR_2 PF07719.17 KOO30694.1 - 0.00031 20.6 12.7 0.13 12.4 0.7 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30694.1 - 0.0032 17.6 2.2 0.33 11.3 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-PHD-like PF15446.6 KOO30694.1 - 0.0054 16.4 2.1 0.017 14.8 2.1 1.9 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain AAA_22 PF13401.6 KOO30694.1 - 0.007 16.6 1.6 0.011 16.0 0.1 2.1 2 0 0 2 2 2 1 AAA domain HDA2-3 PF11496.8 KOO30694.1 - 0.01 15.0 0.0 0.034 13.3 0.0 1.8 1 1 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 TPR_14 PF13428.6 KOO30694.1 - 0.014 16.2 8.8 1.3 10.0 0.2 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO30694.1 - 0.052 13.4 12.7 0.083 12.7 0.6 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Cu-oxidase_2 PF07731.14 KOO30695.1 - 2.7e-14 53.1 8.6 9.5e-09 35.1 1.0 4.8 4 2 0 4 4 4 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 KOO30695.1 - 2e-10 40.7 4.1 2.1e-07 31.0 0.1 4.5 6 1 0 6 6 6 2 Multicopper oxidase DUF1717 PF05414.11 KOO30695.1 - 0.00017 22.0 0.0 0.38 11.2 0.0 3.3 3 0 0 3 3 3 2 Viral domain of unknown function (DUF1717) MORN PF02493.20 KOO30696.1 - 1.2e-163 521.9 315.3 7e-07 28.8 0.2 58.0 60 0 0 60 60 60 50 MORN repeat Ank_2 PF12796.7 KOO30698.1 - 6.8e-65 215.7 14.8 6.4e-15 55.5 0.0 7.5 2 1 6 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO30698.1 - 3.3e-44 148.7 11.9 1.8e-08 34.8 0.0 10.5 5 2 6 11 11 11 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO30698.1 - 4.2e-41 138.5 22.5 4.2e-07 30.1 0.0 10.0 4 2 7 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.30 KOO30698.1 - 8.8e-34 114.5 23.2 0.00068 20.0 0.0 12.9 12 1 0 12 12 12 9 Ankyrin repeat Ank_3 PF13606.6 KOO30698.1 - 5.1e-33 109.4 14.7 0.0097 16.4 0.0 13.9 14 0 0 14 14 14 9 Ankyrin repeat DUF5349 PF17298.2 KOO30700.1 - 3.5 7.3 9.4 5.7 6.6 9.4 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5349) WD40 PF00400.32 KOO30701.1 - 6e-62 204.1 19.9 4.9e-09 36.7 0.1 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat Arm PF00514.23 KOO30701.1 - 3.9e-29 99.7 24.0 2.4e-06 27.4 0.0 8.4 8 0 0 8 8 8 6 Armadillo/beta-catenin-like repeat Ge1_WD40 PF16529.5 KOO30701.1 - 4.4e-19 68.6 9.0 0.011 14.7 0.1 7.2 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO30701.1 - 1.1e-17 64.0 5.1 0.011 16.0 0.0 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO30701.1 - 4.4e-15 55.2 4.1 2.2 8.3 0.0 7.5 7 0 0 7 7 7 5 WD40-like Beta Propeller Repeat eIF2A PF08662.11 KOO30701.1 - 1.4e-09 38.2 0.7 0.00014 21.8 0.1 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 KOO30701.1 - 3e-09 35.8 0.0 0.27 9.5 0.0 4.9 1 1 4 5 5 5 5 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 KOO30701.1 - 2.4e-07 29.6 0.9 0.01 14.4 0.0 3.3 1 1 2 3 3 3 3 Cytochrome D1 heme domain Nbas_N PF15492.6 KOO30701.1 - 1.7e-06 27.6 6.7 1.1 8.5 0.1 5.7 1 1 5 6 6 6 3 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 KOO30701.1 - 7.3e-05 22.2 1.5 0.54 9.5 0.3 3.6 1 1 3 4 4 4 2 WD40-like domain HEAT PF02985.22 KOO30701.1 - 0.00025 21.0 25.1 0.26 11.7 0.1 7.9 9 0 0 9 9 8 2 HEAT repeat Emaravirus_P4 PF16505.5 KOO30701.1 - 0.0011 18.1 0.6 1.5 7.8 0.0 3.9 1 1 2 4 4 4 1 P4 movement protein of Emaravirus, and the 30K superfamily DCX PF03607.17 KOO30701.1 - 0.0015 18.6 0.0 27 4.9 0.0 5.6 7 0 0 7 7 7 0 Doublecortin IKI3 PF04762.12 KOO30701.1 - 0.0051 14.9 3.1 0.25 9.3 1.4 3.6 1 1 0 2 2 2 1 IKI3 family HEAT_2 PF13646.6 KOO30701.1 - 0.014 15.8 41.5 0.13 12.7 6.2 5.4 3 2 3 6 6 6 0 HEAT repeats LigD_N PF13298.6 KOO30701.1 - 0.019 15.3 0.1 15 5.9 0.0 3.8 2 2 2 4 4 4 0 DNA polymerase Ligase (LigD) HEAT_EZ PF13513.6 KOO30701.1 - 0.2 12.2 35.6 3.1 8.4 0.3 7.4 5 2 3 8 8 8 0 HEAT-like repeat Utp8 PF10395.9 KOO30701.1 - 0.87 8.0 3.9 3.4 6.0 0.8 2.5 1 1 1 2 2 2 0 Utp8 family RWD PF05773.22 KOO30702.1 - 0.00027 21.2 0.1 0.0014 18.9 0.1 1.9 1 1 0 1 1 1 1 RWD domain PhoLip_ATPase_C PF16212.5 KOO30704.1 - 3.2e-57 194.2 13.6 3.2e-57 194.2 13.6 1.9 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 KOO30704.1 - 4.1e-14 53.4 0.2 5.6e-06 26.8 0.2 3.5 3 1 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOO30704.1 - 4.2e-08 33.2 0.0 8.2e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KOO30704.1 - 0.00016 21.5 0.0 0.026 14.2 0.0 2.8 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KOO30704.1 - 0.0017 17.9 0.0 0.054 13.0 0.0 2.7 2 0 0 2 2 2 1 E1-E2 ATPase Herpes_UL4 PF03277.13 KOO30704.1 - 0.1 12.2 0.1 0.24 11.0 0.1 1.6 1 0 0 1 1 1 0 Herpesvirus UL4 family Phosphonate-bd PF12974.7 KOO30705.1 - 3.3e-07 30.2 0.0 5.1e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1 PF09084.11 KOO30705.1 - 6.1e-06 26.3 0.0 8e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 KOO30705.1 - 1.1e-05 25.2 0.1 2.8e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 NMT1-like family OpuAC PF04069.12 KOO30705.1 - 0.03 13.9 0.0 0.066 12.8 0.0 1.5 1 1 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system PARP PF00644.20 KOO30706.1 - 1.9e-09 37.4 0.0 4.2e-09 36.3 0.0 1.6 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WW PF00397.26 KOO30706.1 - 2e-05 24.6 2.9 4.9e-05 23.3 2.9 1.7 1 0 0 1 1 1 1 WW domain CUE PF02845.16 KOO30706.1 - 0.0062 16.2 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 CUE domain Ank_2 PF12796.7 KOO30706.1 - 0.044 14.4 0.5 0.11 13.2 0.5 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO30706.1 - 0.081 13.3 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DMA PF03474.14 KOO30706.1 - 0.2 11.3 0.0 0.39 10.4 0.0 1.4 1 0 0 1 1 1 0 DMRTA motif Sdh_cyt PF01127.22 KOO30708.1 - 1.4e-17 63.8 3.2 1.7e-17 63.6 3.2 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit RRM_1 PF00076.22 KOO30709.1 - 8.4e-17 60.8 0.0 1.9e-10 40.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OCRE PF17780.1 KOO30709.1 - 2.6e-10 40.2 5.6 4.1e-10 39.5 5.6 1.3 1 0 0 1 1 1 1 OCRE domain zf-RanBP PF00641.18 KOO30709.1 - 7.9e-05 21.9 1.9 0.00012 21.3 1.9 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_5 PF13893.6 KOO30709.1 - 0.018 14.7 0.0 0.13 11.9 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldo_ket_red PF00248.21 KOO30711.1 - 1.3e-16 60.7 0.0 1.9e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family EMP70 PF02990.16 KOO30712.1 - 5.7e-79 266.1 34.0 7.7e-79 265.7 34.0 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 TMEM219 PF14940.6 KOO30712.1 - 0.015 14.9 1.9 0.031 13.9 1.9 1.5 1 0 0 1 1 1 0 Transmembrane 219 Fea1 PF07692.11 KOO30713.1 - 0.0022 17.1 0.1 0.0045 16.1 0.1 1.5 1 1 0 1 1 1 1 Low iron-inducible periplasmic protein FAM163 PF15069.6 KOO30713.1 - 0.027 14.9 0.8 0.048 14.1 0.8 1.4 1 0 0 1 1 1 0 FAM163 family HemY_N PF07219.13 KOO30713.1 - 0.13 12.5 2.2 11 6.3 0.1 3.0 3 0 0 3 3 3 0 HemY protein N-terminus His_Phos_2 PF00328.22 KOO30714.1 - 0.0018 17.7 0.2 0.0025 17.3 0.2 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RR_TM4-6 PF06459.12 KOO30714.1 - 0.098 12.5 6.4 0.13 12.0 6.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EMP70 PF02990.16 KOO30715.1 - 1.3e-48 166.0 0.0 1.7e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Filamin PF00630.19 KOO30716.1 - 2.5e-07 31.5 0.0 0.015 16.1 0.0 2.7 3 0 0 3 3 3 2 Filamin/ABP280 repeat DUF3306 PF11748.8 KOO30716.1 - 0.76 10.7 5.4 8.1 7.3 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) PDZ PF00595.24 KOO30718.1 - 6.7e-05 23.2 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Fer2 PF00111.27 KOO30718.1 - 0.0014 18.5 1.6 0.0026 17.7 1.6 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain PDZ_6 PF17820.1 KOO30718.1 - 0.16 11.9 0.3 0.5 10.3 0.3 2.0 1 1 0 1 1 1 0 PDZ domain Filamin PF00630.19 KOO30719.1 - 0.0066 17.3 0.0 0.83 10.5 0.0 2.2 2 0 0 2 2 2 2 Filamin/ABP280 repeat Filamin PF00630.19 KOO30720.1 - 0.0015 19.3 0.0 0.0029 18.4 0.0 1.4 1 0 0 1 1 1 1 Filamin/ABP280 repeat YtkA PF13115.6 KOO30720.1 - 0.15 12.7 0.0 0.28 11.8 0.0 1.5 1 0 0 1 1 1 0 YtkA-like CarboxypepD_reg PF13620.6 KOO30720.1 - 0.16 12.3 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain MFS_1 PF07690.16 KOO30722.1 - 4.3e-09 35.8 5.4 4.6e-09 35.7 5.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily FA_desaturase PF00487.24 KOO30722.1 - 0.77 9.5 4.5 0.93 9.3 4.5 1.0 1 0 0 1 1 1 0 Fatty acid desaturase MFS_1 PF07690.16 KOO30723.1 - 1.5e-10 40.6 14.5 2.6e-10 39.8 14.5 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO30723.1 - 4.2e-05 22.6 0.5 5.4e-05 22.3 0.5 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter Mito_carr PF00153.27 KOO30724.1 - 2.8e-54 181.0 0.8 4.3e-18 65.0 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOO30724.1 - 0.11 11.7 0.7 0.86 8.7 0.0 2.5 3 0 0 3 3 3 0 Gammaproteobacterial serine protease PDEase_I PF00233.19 KOO30725.1 - 1.2e-16 61.2 0.0 1.6e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Allantoicase PF03561.15 KOO30728.1 - 2.3e-47 160.6 0.0 1.7e-36 125.3 0.0 2.2 2 0 0 2 2 2 2 Allantoicase repeat Macin PF14865.6 KOO30729.1 - 0.13 12.8 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 Macin CE2_N PF17996.1 KOO30730.1 - 5.8e-08 32.7 0.0 2.9 7.9 0.0 7.4 7 1 0 8 8 8 1 Carbohydrate esterase 2 N-terminal Cadherin_C_2 PF16492.5 KOO30730.1 - 1.4e-07 32.1 1.0 28 5.5 0.1 6.8 7 0 0 7 7 7 2 Cadherin cytoplasmic C-terminal RS4NT PF08071.12 KOO30730.1 - 0.05 13.7 0.0 44 4.3 0.0 3.9 4 0 0 4 4 4 0 RS4NT (NUC023) domain DUF3042 PF11240.8 KOO30730.1 - 0.1 12.6 6.3 4.5 7.4 0.2 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3042) tRNA_int_endo PF01974.17 KOO30730.1 - 2.4 8.3 11.5 31 4.7 0.0 5.6 6 0 0 6 6 6 0 tRNA intron endonuclease, catalytic C-terminal domain Arb1 PF09692.10 KOO30730.1 - 5.9 5.9 5.3 1.2e+02 1.7 0.0 4.1 4 0 0 4 4 4 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Yip1 PF04893.17 KOO30731.1 - 5e-13 49.1 9.3 6.7e-13 48.7 9.3 1.1 1 0 0 1 1 1 1 Yip1 domain zf-RING_2 PF13639.6 KOO30732.1 - 2.4e-08 34.1 7.3 3.6e-08 33.6 7.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOO30732.1 - 9.7e-07 28.6 6.2 1.5e-06 28.0 6.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KOO30732.1 - 5.1e-06 26.2 5.5 7.5e-06 25.6 5.5 1.3 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KOO30732.1 - 1e-05 25.7 10.6 3.8e-05 23.9 10.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KOO30732.1 - 1.1e-05 25.1 3.1 2.2e-05 24.1 3.1 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KOO30732.1 - 1.9e-05 24.4 6.0 3.6e-05 23.5 6.0 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO30732.1 - 0.00014 21.7 5.0 0.00024 20.9 5.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KOO30732.1 - 0.00018 21.0 8.2 0.00031 20.3 8.2 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 KOO30732.1 - 0.00048 20.0 5.7 0.00072 19.5 5.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO30732.1 - 0.00067 19.6 2.5 0.0012 18.8 2.5 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-UDP PF14569.6 KOO30732.1 - 0.0009 19.3 5.2 0.0016 18.5 5.2 1.3 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-RING-like PF08746.11 KOO30732.1 - 0.018 15.3 9.4 0.029 14.7 9.4 1.3 1 0 0 1 1 1 0 RING-like domain zf-ANAPC11 PF12861.7 KOO30732.1 - 0.021 14.9 5.4 0.043 13.9 5.4 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 KOO30732.1 - 0.037 13.9 8.1 0.06 13.2 8.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 SAP PF02037.27 KOO30732.1 - 0.038 13.8 0.3 0.07 12.9 0.3 1.4 1 0 0 1 1 1 0 SAP domain PHD PF00628.29 KOO30732.1 - 0.18 11.8 6.7 0.28 11.1 6.7 1.3 1 0 0 1 1 1 0 PHD-finger zf-RING_9 PF13901.6 KOO30732.1 - 0.47 10.4 4.5 0.74 9.8 4.5 1.2 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon FANCL_C PF11793.8 KOO30732.1 - 2.5 8.4 8.6 33 4.7 8.6 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.6 KOO30732.1 - 2.6 8.0 12.0 2.1 8.4 5.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 DZR PF12773.7 KOO30732.1 - 4.4 7.4 8.4 60 3.8 8.7 2.1 1 1 0 1 1 1 0 Double zinc ribbon Ribosomal_L25p PF01386.19 KOO30734.1 - 1e-07 32.4 0.0 1.8e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L25p family Ribosomal_TL5_C PF14693.6 KOO30734.1 - 5.3e-07 29.9 0.0 9.7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein TL5, C-terminal domain Exo_endo_phos PF03372.23 KOO30735.1 - 0.00023 20.8 1.9 0.00043 19.9 0.2 2.1 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family AAA_33 PF13671.6 KOO30736.1 - 1e-07 32.2 0.4 1.2e-07 32.0 0.4 1.1 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KOO30736.1 - 0.00067 19.0 0.3 0.00085 18.7 0.3 1.2 1 0 0 1 1 1 1 Zeta toxin Ank_2 PF12796.7 KOO30737.1 - 3.6e-05 24.3 0.2 6.3e-05 23.5 0.2 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) IBR PF01485.21 KOO30737.1 - 0.00011 22.4 12.8 0.00011 22.4 12.8 2.2 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain Ank_3 PF13606.6 KOO30737.1 - 0.39 11.4 1.8 1.8 9.4 0.1 2.7 3 0 0 3 3 3 0 Ankyrin repeat SLATT_1 PF18181.1 KOO30738.1 - 0.19 11.7 0.9 0.39 10.6 0.1 1.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 Tic22 PF04278.12 KOO30739.1 - 0.00089 18.7 0.0 0.0014 18.0 0.0 1.4 1 1 0 1 1 1 1 Tic22-like family Hint PF01079.20 KOO30740.1 - 0.0027 17.2 0.0 0.0038 16.8 0.0 1.1 1 0 0 1 1 1 1 Hint module DUF1454 PF07305.12 KOO30741.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1454) Sel1 PF08238.12 KOO30742.1 - 7.6e-08 32.8 8.5 0.0018 18.9 2.1 3.6 3 0 0 3 3 3 2 Sel1 repeat U-box PF04564.15 KOO30742.1 - 1.9e-05 24.8 0.0 4.1e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 KOO30742.1 - 0.00069 19.7 0.0 0.0013 18.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO30742.1 - 0.0018 18.1 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Nucleoporin_FG PF13634.6 KOO30744.1 - 0.0092 16.8 8.3 0.019 15.8 8.3 1.5 1 0 0 1 1 1 1 Nucleoporin FG repeat region NUP50 PF08911.11 KOO30745.1 - 3.5e-10 40.4 20.2 2.6e-06 28.0 20.2 4.0 1 1 0 1 1 1 1 NUP50 (Nucleoporin 50 kDa) Cupin_8 PF13621.6 KOO30746.1 - 2.9e-34 119.0 0.0 3.3e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain RPN7 PF10602.9 KOO30747.1 - 0.014 15.1 0.5 0.028 14.1 0.5 1.4 1 0 0 1 1 1 0 26S proteasome subunit RPN7 TPR_19 PF14559.6 KOO30747.1 - 0.023 15.2 14.9 0.25 11.9 2.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO30747.1 - 0.029 15.0 21.6 0.72 10.5 5.5 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30747.1 - 0.063 13.5 3.1 1.9 8.9 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30747.1 - 0.065 14.1 16.1 0.53 11.2 1.8 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat ESX-1_EspG PF14011.6 KOO30747.1 - 0.17 11.5 9.0 0.031 13.9 2.9 2.1 1 1 1 2 2 2 0 EspG family MIT PF04212.18 KOO30747.1 - 0.78 9.9 5.9 4.9 7.3 2.8 2.7 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.17 KOO30747.1 - 3.5 8.0 17.6 0.28 11.4 2.8 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO30747.1 - 6.4 6.8 8.1 10 6.1 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat GSIII_N PF12437.8 KOO30748.1 - 9e-51 171.7 0.0 3.4e-50 169.8 0.0 1.9 2 0 0 2 2 2 1 Glutamine synthetase type III N terminal Gln-synt_C-ter PF18318.1 KOO30748.1 - 7.3e-31 106.5 0.0 1.5e-30 105.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase C-terminal domain Gln-synt_C PF00120.24 KOO30748.1 - 2.3e-18 66.3 0.0 7.3e-18 64.7 0.0 1.7 2 0 0 2 2 2 1 Glutamine synthetase, catalytic domain DAGK_acc PF00609.19 KOO30749.1 - 1.1e-37 129.9 0.0 2.8e-37 128.5 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KOO30749.1 - 6.9e-16 58.0 0.0 1.9e-15 56.6 0.0 1.8 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain V-ATPase_H_N PF03224.14 KOO30749.1 - 0.0002 20.8 3.5 0.14 11.4 0.5 2.3 1 1 0 2 2 2 2 V-ATPase subunit H Arm PF00514.23 KOO30749.1 - 0.00055 19.9 14.2 0.48 10.5 0.0 5.0 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KOO30749.1 - 0.0029 17.1 0.8 0.65 9.6 0.1 2.7 2 0 0 2 2 2 2 Atypical Arm repeat Arm PF00514.23 KOO30750.1 - 8.4e-06 25.7 3.1 0.092 12.8 0.1 3.6 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat EF-hand_5 PF13202.6 KOO30750.1 - 1e-05 24.8 0.1 2.1e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO30750.1 - 0.00026 20.3 0.1 0.00058 19.2 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO30750.1 - 0.001 18.8 0.1 0.003 17.4 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain V-ATPase_H_N PF03224.14 KOO30750.1 - 0.0036 16.6 1.0 0.0045 16.3 1.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H Arm_3 PF16186.5 KOO30750.1 - 0.0074 15.8 0.0 0.027 14.0 0.0 1.9 2 0 0 2 2 2 1 Atypical Arm repeat EF-hand_7 PF13499.6 KOO30750.1 - 0.011 16.2 0.0 0.028 14.9 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair PP-binding_2 PF14573.6 KOO30750.1 - 0.029 14.6 0.0 0.06 13.6 0.0 1.5 1 0 0 1 1 1 0 Acyl-carrier EF-hand_8 PF13833.6 KOO30750.1 - 0.13 12.1 0.1 0.33 10.8 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 KOO30751.1 - 6.5e-13 47.2 1.3 1.1e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO30751.1 - 5.5e-12 44.6 0.9 4e-06 26.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO30751.1 - 1.2e-11 43.5 2.2 3.5e-06 26.3 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO30751.1 - 4.4e-11 43.1 1.2 1e-10 41.9 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO30751.1 - 5.8e-10 38.9 0.6 2.6e-09 36.8 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO30751.1 - 5.8e-05 23.3 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain DUF5580 PF17743.1 KOO30751.1 - 0.00027 19.7 2.5 0.00084 18.0 0.0 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF5580) EF-hand_4 PF12763.7 KOO30751.1 - 0.0051 16.7 0.1 0.01 15.8 0.1 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO30751.1 - 0.012 15.9 0.0 0.012 15.9 0.0 2.6 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO30751.1 - 0.032 15.1 0.0 0.082 13.8 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain Phage_GPO PF05929.11 KOO30751.1 - 0.4 10.3 7.2 4 7.0 0.0 2.2 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF2291 PF10054.9 KOO30751.1 - 0.53 10.0 2.7 28 4.4 0.1 2.9 2 1 1 3 3 3 0 Predicted periplasmic lipoprotein (DUF2291) Pkinase PF00069.25 KOO30752.1 - 2.8e-32 112.1 0.0 4.4e-21 75.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30752.1 - 6.4e-30 104.3 0.0 1.7e-22 79.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase EF-hand_7 PF13499.6 KOO30752.1 - 4.6e-14 52.6 2.6 4.4e-09 36.6 0.5 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO30752.1 - 4.6e-11 41.4 0.4 8.8e-05 21.8 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO30752.1 - 1.3e-08 34.1 0.1 0.00024 20.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO30752.1 - 1.9e-08 33.4 0.2 0.00014 21.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO30752.1 - 0.0017 18.1 1.6 0.035 14.0 0.6 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO30752.1 - 0.081 13.3 0.1 0.24 11.7 0.1 1.9 1 0 0 1 1 1 0 EF-hand domain PDZ_6 PF17820.1 KOO30752.1 - 0.12 12.2 0.1 0.49 10.3 0.1 2.0 2 0 0 2 2 2 0 PDZ domain Borrelia_P83 PF05262.11 KOO30752.1 - 0.74 8.2 4.9 12 4.3 4.7 2.0 2 0 0 2 2 2 0 Borrelia P83/100 protein Myb_DNA-binding PF00249.31 KOO30753.1 - 7.8e-26 90.0 1.4 1.2e-14 54.2 0.3 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO30753.1 - 2.2e-19 69.5 0.3 1.2e-15 57.5 0.1 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF268 PF03269.14 KOO30753.1 - 1.6e-06 28.1 0.0 2.8e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Caenorhabditis protein of unknown function, DUF268 SLIDE PF09111.10 KOO30753.1 - 1e-05 25.5 0.0 0.061 13.3 0.0 2.6 2 0 0 2 2 2 2 SLIDE SANT_DAMP1_like PF16282.5 KOO30753.1 - 0.0063 16.7 0.0 0.88 9.8 0.0 2.5 1 1 1 2 2 2 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 KOO30753.1 - 0.14 12.0 0.0 0.7 9.8 0.0 2.0 1 1 1 2 2 2 0 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 KOO30753.1 - 1.5 9.2 4.1 16 6.0 0.4 2.9 2 2 0 2 2 2 0 Myb/SANT-like DNA-binding domain Ank_2 PF12796.7 KOO30754.1 - 1.5e-27 96.0 2.7 7.3e-13 48.9 0.1 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO30754.1 - 3.6e-26 91.2 6.9 1.1e-07 32.3 0.0 6.6 6 1 1 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO30754.1 - 3.8e-19 68.5 5.8 0.0045 17.3 0.0 5.6 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO30754.1 - 8.5e-19 65.7 1.4 0.00059 20.1 0.0 6.1 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 KOO30754.1 - 2e-17 62.7 14.0 1.2e-05 25.5 0.4 6.7 7 0 0 7 7 7 4 Ankyrin repeat Lin0512_fam PF09585.10 KOO30755.1 - 1.4e-09 37.9 0.0 2.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein (Lin0512_fam) DUF4680 PF15730.5 KOO30755.1 - 0.088 13.2 0.2 0.14 12.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) HypF_C PF17788.1 KOO30756.1 - 0.18 12.5 0.0 0.37 11.5 0.0 1.4 1 0 0 1 1 1 0 HypF Kae1-like domain Sel1 PF08238.12 KOO30757.1 - 4.1e-16 59.1 1.7 0.00024 21.7 0.1 3.4 3 0 0 3 3 3 3 Sel1 repeat DUF1199 PF06712.11 KOO30757.1 - 0.33 11.0 0.1 0.33 11.0 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1199) Bap31_Bap29_C PF18035.1 KOO30757.1 - 4.8 7.3 8.1 7.8 6.6 0.3 2.5 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain TPT PF03151.16 KOO30758.1 - 5.4e-80 268.8 7.1 6.4e-80 268.6 7.1 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO30758.1 - 4e-16 59.4 21.0 4e-08 33.5 7.1 2.7 2 1 0 2 2 2 2 EamA-like transporter family 7TM_GPCR_Srt PF10321.9 KOO30758.1 - 0.0083 15.1 0.1 0.013 14.5 0.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srt RPGR1_C PF18111.1 KOO30759.1 - 5e-70 234.7 0.0 3e-07 30.5 0.1 10.6 10 0 0 10 10 10 9 Retinitis pigmentosa G-protein regulator interacting C-terminal NT-C2 PF10358.9 KOO30759.1 - 0.0063 16.2 0.1 5 6.8 0.0 3.8 5 0 0 5 5 5 2 N-terminal C2 in EEIG1 and EHBP1 proteins Glyco_hydro_31 PF01055.26 KOO30760.1 - 4.5e-80 270.0 4.5 5.9e-80 269.6 4.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 KOO30760.1 - 3.3e-08 33.7 0.0 7.6e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) PAN_4 PF14295.6 KOO30760.1 - 2.3e-07 30.6 2.4 2.3e-07 30.6 2.4 2.0 2 0 0 2 2 2 1 PAN domain PAN_1 PF00024.26 KOO30760.1 - 0.0092 15.9 0.2 0.02 14.8 0.2 1.5 1 0 0 1 1 1 1 PAN domain MANEC PF07502.14 KOO30760.1 - 0.016 15.4 0.5 0.033 14.5 0.5 1.4 1 0 0 1 1 1 0 MANEC domain Pkinase PF00069.25 KOO30761.1 - 6.7e-42 143.7 0.0 3.1e-41 141.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30761.1 - 2e-15 56.8 0.0 3.1e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RabGAP-TBC PF00566.18 KOO30762.1 - 7e-46 156.6 0.0 9.5e-46 156.1 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LRR_6 PF13516.6 KOO30765.1 - 3.2e-13 48.6 3.4 0.013 15.5 0.0 5.8 6 0 0 6 6 6 3 Leucine Rich repeat LRR_1 PF00560.33 KOO30765.1 - 5.9e-06 26.1 0.0 7.6 7.5 0.0 5.0 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_8 PF13855.6 KOO30765.1 - 0.00012 21.8 1.1 22 4.9 0.0 5.4 5 0 0 5 5 5 1 Leucine rich repeat LRR_4 PF12799.7 KOO30765.1 - 0.00038 20.8 0.1 62 4.2 0.1 4.9 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) VWA PF00092.28 KOO30766.1 - 3.3e-17 63.3 0.0 3.8e-17 63.1 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KOO30766.1 - 1.6e-09 38.3 0.1 3.7e-09 37.2 0.0 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 KOO30766.1 - 0.00017 21.1 0.1 0.0002 20.8 0.1 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF1194 PF06707.11 KOO30766.1 - 0.0011 18.2 0.5 0.0014 17.8 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1194) VWA_3 PF13768.6 KOO30766.1 - 0.0096 15.9 0.0 0.013 15.4 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Pkinase_Tyr PF07714.17 KOO30769.1 - 1.1e-34 119.9 0.0 1.5e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO30769.1 - 8.4e-33 113.8 0.0 1.3e-32 113.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PP2C PF00481.21 KOO30769.1 - 1.2e-24 87.4 0.0 1.9e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO30769.1 - 5.4e-06 26.5 0.0 0.0052 16.7 0.1 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KOO30769.1 - 0.00075 19.2 2.8 0.0074 15.9 2.6 2.2 1 1 1 2 2 2 1 Protein phosphatase 2C Pkinase_fungal PF17667.1 KOO30769.1 - 0.025 13.3 0.0 0.044 12.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 KOO30769.1 - 0.057 13.3 0.2 0.15 12.0 0.2 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family TetR_C_11 PF16859.5 KOO30769.1 - 0.12 12.7 0.6 0.33 11.3 0.1 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PH PF00169.29 KOO30770.1 - 1e-10 42.1 0.0 9e-06 26.1 0.0 2.2 2 0 0 2 2 2 2 PH domain PDZ_6 PF17820.1 KOO30770.1 - 1.2e-05 25.1 1.9 2.5e-05 24.0 1.6 1.8 1 1 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO30770.1 - 3e-05 24.3 0.5 7.2e-05 23.1 0.5 1.6 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KOO30770.1 - 0.0009 19.2 0.3 0.0023 17.8 0.3 1.7 1 0 0 1 1 1 1 Tricorn protease PDZ domain PH_11 PF15413.6 KOO30770.1 - 0.0032 17.9 0.0 0.028 14.8 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PDZ_2 PF13180.6 KOO30770.1 - 0.0069 16.7 0.3 0.015 15.6 0.2 1.6 1 1 0 1 1 1 1 PDZ domain MnmE_helical PF12631.7 KOO30771.1 - 2.2e-51 174.9 0.0 2.8e-51 174.6 0.0 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 KOO30771.1 - 3.9e-25 88.4 0.0 8.1e-25 87.4 0.0 1.5 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 KOO30771.1 - 2.1e-18 66.4 0.0 4.3e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOO30771.1 - 4e-05 23.7 0.0 6.5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Dynamin family FeoB_N PF02421.18 KOO30771.1 - 0.00016 21.2 0.0 0.00026 20.5 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 KOO30771.1 - 0.0015 19.1 0.0 0.0055 17.2 0.0 1.8 1 1 1 2 2 2 1 ABC transporter Arf PF00025.21 KOO30771.1 - 0.018 14.5 0.0 0.091 12.2 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KOO30771.1 - 0.029 14.3 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_28 PF13521.6 KOO30771.1 - 0.043 14.1 0.0 0.098 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOO30771.1 - 0.21 11.3 0.0 0.37 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO30771.1 - 0.55 10.6 6.6 0.45 10.9 0.1 3.0 2 1 1 3 3 3 0 AAA ATPase domain IQ PF00612.27 KOO30772.1 - 0.071 12.9 0.4 0.29 11.1 0.4 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif CRAL_TRIO PF00650.20 KOO30773.1 - 8.3e-14 51.6 0.0 1.2e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain MG2 PF01835.19 KOO30774.1 - 0.013 15.9 0.0 1.1 9.7 0.0 2.6 2 0 0 2 2 2 0 MG2 domain bMG3 PF11974.8 KOO30774.1 - 0.09 12.8 0.1 0.23 11.5 0.1 1.7 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain GUN4 PF05419.12 KOO30775.1 - 0.085 12.9 0.0 0.19 11.8 0.0 1.5 1 1 0 1 1 1 0 GUN4-like zf-C2H2_2 PF12756.7 KOO30778.1 - 2.7e-21 75.8 0.0 5.6e-19 68.4 0.1 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) Ploopntkinase3 PF18751.1 KOO30778.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 2OG-FeII_Oxy_3 PF13640.6 KOO30779.1 - 5.4e-13 49.7 0.0 1.4e-12 48.3 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO30779.1 - 3.1e-05 24.6 0.0 0.00042 20.9 0.0 2.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 KOO30779.1 - 0.043 14.1 0.0 0.32 11.2 0.0 2.2 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 KOO30779.1 - 0.11 13.0 0.7 0.25 11.8 0.0 2.1 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase PABP PF00658.18 KOO30780.1 - 2.8e-07 30.6 0.0 5.6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Kinesin PF00225.23 KOO30781.1 - 8.9e-47 159.6 0.0 1.8e-46 158.6 0.0 1.4 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO30781.1 - 1.1e-05 25.4 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding NACHT PF05729.12 KOO30781.1 - 0.0041 17.0 0.0 0.0072 16.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain DAP3 PF10236.9 KOO30781.1 - 0.007 15.6 0.1 0.011 14.9 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 KOO30781.1 - 0.0072 16.6 0.2 0.02 15.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KOO30781.1 - 0.012 14.7 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 KOO30781.1 - 0.015 14.8 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 KOO30781.1 - 0.035 13.5 0.2 0.069 12.5 0.2 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ResIII PF04851.15 KOO30781.1 - 0.039 14.0 0.1 0.065 13.2 0.1 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_16 PF13191.6 KOO30781.1 - 0.042 14.2 3.0 0.094 13.1 2.5 2.0 1 1 0 1 1 1 0 AAA ATPase domain CbiA PF01656.23 KOO30781.1 - 0.076 13.1 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain RNA_helicase PF00910.22 KOO30781.1 - 0.087 13.2 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Fucose_iso_N2 PF07882.12 KOO30782.1 - 0.016 14.8 0.7 0.026 14.1 0.4 1.5 1 1 0 1 1 1 0 L-fucose isomerase, second N-terminal domain Nse4_C PF08743.10 KOO30782.1 - 0.1 12.9 0.2 22 5.4 0.0 2.5 2 1 0 2 2 2 0 Nse4 C-terminal IQ PF00612.27 KOO30782.1 - 0.14 12.0 5.9 0.18 11.7 0.5 3.2 3 0 0 3 3 3 0 IQ calmodulin-binding motif DUF892 PF05974.12 KOO30783.1 - 0.011 15.7 3.2 0.084 12.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF892) ZapD PF07072.11 KOO30783.1 - 0.086 12.6 0.6 0.24 11.2 0.6 1.7 1 0 0 1 1 1 0 Cell division protein RXLR PF16810.5 KOO30783.1 - 0.42 11.0 0.0 0.42 11.0 0.0 2.9 4 0 0 4 4 4 0 RXLR phytopathogen effector protein, Avirulence activity PCRF PF03462.18 KOO30783.1 - 1.1 9.0 5.1 0.49 10.2 1.7 2.1 2 0 0 2 2 2 0 PCRF domain DUF2939 PF11159.8 KOO30784.1 - 0.00055 20.3 0.1 0.51 10.8 0.0 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF2939) Exop_C PF18559.1 KOO30784.1 - 0.095 12.6 0.0 5.9 6.7 0.0 2.9 3 1 1 4 4 4 0 Galactose-binding domain-like LRR_6 PF13516.6 KOO30785.1 - 6.6e-45 147.4 20.4 4.3e-05 23.2 0.0 9.7 10 0 0 10 10 10 9 Leucine Rich repeat LRR_4 PF12799.7 KOO30785.1 - 2.8e-06 27.6 5.8 0.27 11.7 0.0 6.3 3 3 4 7 7 7 2 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.12 KOO30785.1 - 0.0023 18.1 2.4 2.5 8.4 0.0 4.6 3 1 3 6 6 6 1 RNA 2'-O ribose methyltransferase substrate binding LRR_1 PF00560.33 KOO30785.1 - 0.0077 16.6 0.0 2.2e+02 3.1 0.0 5.5 5 0 0 5 5 5 0 Leucine Rich Repeat CoatB PF10389.9 KOO30785.1 - 0.25 11.2 24.0 3 7.8 0.2 7.1 6 2 1 7 7 7 0 Bacteriophage coat protein B CbiG_N PF11760.8 KOO30785.1 - 7.6 6.6 29.2 11 6.1 0.1 7.2 6 2 1 7 7 7 0 Cobalamin synthesis G N-terminal RRM_1 PF00076.22 KOO30786.1 - 1.2e-19 69.8 0.0 2.3e-13 49.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4283 PF14111.6 KOO30786.1 - 0.068 12.7 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) PHM7_cyt PF14703.6 KOO30786.1 - 0.13 12.5 0.0 6.3 7.0 0.1 2.9 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter RRM_Rrp7 PF17799.1 KOO30786.1 - 0.23 11.3 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain EF-hand_1 PF00036.32 KOO30787.1 - 1.9e-18 64.5 7.4 6.3e-05 22.3 0.1 5.3 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 KOO30787.1 - 8.3e-18 62.7 6.0 0.00043 20.0 0.1 5.9 5 0 0 5 5 5 4 EF-hand domain DnaJ PF00226.31 KOO30787.1 - 1.6e-16 60.2 1.6 3.6e-16 59.0 1.6 1.6 1 0 0 1 1 1 1 DnaJ domain EF-hand_8 PF13833.6 KOO30787.1 - 7.1e-14 51.4 0.5 1.5e-06 28.0 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO30787.1 - 8e-14 51.9 5.7 2.8e-05 24.5 0.1 4.2 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO30787.1 - 5.4e-11 41.5 4.0 2e-05 23.8 0.1 4.1 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 KOO30787.1 - 0.92 9.9 2.5 32 4.9 0.0 3.7 3 2 1 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region MerR-DNA-bind PF09278.11 KOO30788.1 - 9.1 6.9 9.1 15 6.2 7.4 2.5 2 0 0 2 2 2 0 MerR, DNA binding COR PF16095.5 KOO30789.1 - 1.2e-17 64.4 0.0 2.5e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 KOO30789.1 - 2.8e-05 24.3 0.0 0.09 13.0 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ank_5 PF13857.6 KOO30789.1 - 8.4e-05 22.8 0.0 0.0003 21.0 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO30789.1 - 0.0033 17.8 0.1 0.014 15.9 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeat Ras PF00071.22 KOO30789.1 - 0.0043 16.7 0.0 3 7.4 0.0 2.3 2 0 0 2 2 2 2 Ras family VIGSSK PF14773.6 KOO30789.1 - 0.0053 16.9 0.1 0.0053 16.9 0.1 2.0 2 0 0 2 2 2 1 Helicase-associated putative binding domain, C-terminal Ank_2 PF12796.7 KOO30789.1 - 0.081 13.5 0.1 0.28 11.8 0.1 2.0 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO30789.1 - 0.15 12.7 0.0 0.64 10.8 0.0 2.1 1 0 0 1 1 1 0 Ankyrin repeat Ank_4 PF13637.6 KOO30789.1 - 0.16 12.6 0.0 0.46 11.1 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) zf-U1 PF06220.12 KOO30790.1 - 4.4e-08 32.8 0.2 9.2e-08 31.7 0.2 1.5 1 0 0 1 1 1 1 U1 zinc finger DUF1033 PF06279.11 KOO30790.1 - 0.078 13.2 0.4 0.12 12.6 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1033) zf-C2H2_jaz PF12171.8 KOO30790.1 - 0.81 10.1 6.8 3.1 8.2 6.8 1.9 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding G-patch PF01585.23 KOO30791.1 - 1.3e-14 53.8 5.7 1.5e-14 53.6 4.3 1.9 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 KOO30791.1 - 3.3e-10 39.9 1.9 3.3e-10 39.9 1.9 2.0 2 0 0 2 2 2 1 G-patch domain zf-PARP PF00645.18 KOO30792.1 - 2.5e-29 102.0 3.1 5e-16 59.3 0.1 2.5 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WGR PF05406.15 KOO30792.1 - 1.1e-11 44.6 0.3 3e-11 43.2 0.3 1.7 1 0 0 1 1 1 1 WGR domain ART PF01129.18 KOO30792.1 - 2.3e-11 43.4 0.0 4e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase PARP_reg PF02877.14 KOO30792.1 - 4.2e-08 33.4 0.0 9e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain SAP PF02037.27 KOO30792.1 - 6.1e-08 32.2 0.7 1.8e-07 30.8 0.7 1.9 1 0 0 1 1 1 1 SAP domain ADPrib_exo_Tox PF03496.14 KOO30792.1 - 1.1e-05 24.9 0.0 8.5e-05 22.0 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme TF_Zn_Ribbon PF08271.12 KOO30792.1 - 0.078 12.5 0.7 12 5.5 0.2 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Amnionless PF14828.6 KOO30793.1 - 0.0033 16.3 1.0 0.0038 16.1 1.0 1.0 1 0 0 1 1 1 1 Amnionless Mid2 PF04478.12 KOO30793.1 - 0.0078 16.1 1.2 0.0078 16.1 1.2 1.6 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor LAX PF15681.5 KOO30793.1 - 0.012 14.5 0.1 0.021 13.6 0.1 1.4 1 0 0 1 1 1 0 Lymphocyte activation family X Adeno_E3_CR2 PF02439.15 KOO30793.1 - 0.026 14.3 3.4 0.026 14.3 3.4 2.1 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 SP24 PF16504.5 KOO30793.1 - 0.062 13.3 2.7 0.11 12.5 0.1 2.2 2 0 0 2 2 2 0 Putative virion membrane protein of plant and insect virus TraL PF07178.11 KOO30793.1 - 0.083 13.4 0.6 0.083 13.4 0.6 1.5 2 0 0 2 2 2 0 TraL protein Syndecan PF01034.20 KOO30793.1 - 0.093 12.7 2.2 0.19 11.7 2.2 1.5 1 0 0 1 1 1 0 Syndecan domain DUF4448 PF14610.6 KOO30793.1 - 0.15 11.9 0.5 0.18 11.6 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) EphA2_TM PF14575.6 KOO30793.1 - 0.22 12.4 1.3 0.36 11.7 1.3 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 KOO30793.1 - 0.23 11.4 3.7 0.12 12.2 1.3 1.8 1 1 1 2 2 2 0 TMEM154 protein family Stevor PF17410.2 KOO30793.1 - 1.2 8.6 7.7 1.6 8.2 7.7 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame SNAP PF14938.6 KOO30794.1 - 3.9e-99 331.6 26.8 4.5e-99 331.4 26.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KOO30794.1 - 3.5e-09 36.8 24.3 0.0004 20.6 0.9 4.4 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_6 PF13174.6 KOO30794.1 - 9.3e-07 29.1 20.3 0.15 12.8 1.3 6.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO30794.1 - 2.8e-06 27.0 17.8 0.56 10.4 0.8 6.3 3 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30794.1 - 8.8e-05 22.4 20.0 0.18 12.1 2.4 7.1 4 1 3 7 7 7 1 Tetratricopeptide repeat TRAPPC-Trs85 PF12739.7 KOO30794.1 - 0.0004 19.5 7.4 0.00055 19.0 7.4 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_16 PF13432.6 KOO30794.1 - 0.00076 20.1 22.8 0.05 14.3 7.2 5.0 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30794.1 - 0.003 18.2 18.7 0.45 11.5 1.2 6.5 4 1 3 7 7 7 1 Tetratricopeptide repeat PPR_long PF17177.4 KOO30794.1 - 0.0082 15.5 8.0 0.027 13.9 0.7 3.2 1 1 2 3 3 3 1 Pentacotripeptide-repeat region of PRORP NSF PF02071.20 KOO30794.1 - 0.022 15.4 32.0 13 7.1 0.1 8.4 6 2 2 8 8 8 0 Aromatic-di-Alanine (AdAR) repeat PHA_gran_rgn PF09650.10 KOO30794.1 - 0.023 15.0 2.3 0.33 11.3 0.0 3.5 3 1 1 4 4 4 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) PDEase_I PF00233.19 KOO30794.1 - 0.043 13.5 0.1 0.076 12.7 0.1 1.5 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase TPR_19 PF14559.6 KOO30794.1 - 0.17 12.5 19.7 2.2 8.9 5.1 5.3 2 1 3 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO30794.1 - 0.28 11.4 35.7 0.061 13.5 4.3 7.1 6 2 3 9 9 7 0 Tetratricopeptide repeat RPN7 PF10602.9 KOO30794.1 - 0.3 10.8 11.8 0.057 13.1 2.3 3.5 1 1 2 3 3 3 0 26S proteasome subunit RPN7 TPR_1 PF00515.28 KOO30794.1 - 0.63 10.0 28.4 0.17 11.7 3.7 6.1 6 1 1 7 7 7 0 Tetratricopeptide repeat DUF2225 PF09986.9 KOO30794.1 - 5.2 6.7 15.8 3.5e+02 0.8 15.8 2.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_9 PF13371.6 KOO30794.1 - 8.8 6.6 6.6 25 5.1 0.2 3.4 2 2 1 3 3 3 0 Tetratricopeptide repeat HEAT_2 PF13646.6 KOO30795.1 - 1.2e-42 144.2 44.1 1.8e-10 41.0 0.1 6.2 2 2 5 7 7 7 7 HEAT repeats HEAT PF02985.22 KOO30795.1 - 3.3e-34 114.0 19.7 0.00059 19.9 0.0 11.6 10 1 1 11 11 11 8 HEAT repeat HEAT_EZ PF13513.6 KOO30795.1 - 1.7e-24 85.9 19.0 0.0091 16.5 0.1 10.4 9 1 2 11 11 10 9 HEAT-like repeat ART PF01129.18 KOO30795.1 - 5.9e-12 45.4 0.0 1.1e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase PARP_reg PF02877.14 KOO30795.1 - 1e-10 41.9 0.0 3.2e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 KOO30795.1 - 2.9e-09 36.8 0.1 5.9e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 WGR domain Cnd1 PF12717.7 KOO30795.1 - 7e-09 35.9 1.6 0.21 11.6 0.2 5.4 2 1 3 5 5 5 4 non-SMC mitotic condensation complex subunit 1 SAP PF02037.27 KOO30795.1 - 4.6e-08 32.6 0.3 4.6e-08 32.6 0.3 3.9 5 0 0 5 5 5 1 SAP domain Cohesin_HEAT PF12765.7 KOO30795.1 - 0.00096 19.4 45.9 0.23 11.8 0.4 10.5 11 0 0 11 11 11 2 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.20 KOO30795.1 - 0.003 16.2 0.0 0.03 12.9 0.0 2.1 1 1 0 1 1 1 1 Adaptin N terminal region Arm PF00514.23 KOO30795.1 - 0.0047 16.9 5.8 11 6.2 0.0 5.7 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 KOO30795.1 - 0.013 15.7 0.3 14 5.9 0.1 4.0 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 DNA_alkylation PF08713.11 KOO30795.1 - 0.016 14.9 0.1 12 5.6 0.0 4.1 3 1 2 5 5 5 0 DNA alkylation repair enzyme ADPrib_exo_Tox PF03496.14 KOO30795.1 - 0.071 12.4 0.1 0.25 10.7 0.0 1.8 2 0 0 2 2 2 0 ADP-ribosyltransferase exoenzyme ATP_bind_1 PF03029.17 KOO30795.1 - 0.2 11.4 0.0 59 3.3 0.0 3.2 1 1 0 3 3 3 0 Conserved hypothetical ATP binding protein HEAT_PBS PF03130.16 KOO30795.1 - 0.27 12.0 34.9 17 6.4 0.0 9.3 10 0 0 10 10 8 0 PBS lyase HEAT-like repeat EF-hand_1 PF00036.32 KOO30796.1 - 6.6e-24 81.6 2.5 0.00024 20.4 0.1 5.6 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 KOO30796.1 - 2.6e-21 73.7 7.9 0.00058 19.6 0.2 5.6 5 0 0 5 5 5 5 EF-hand domain EF-hand_7 PF13499.6 KOO30796.1 - 7.2e-19 68.0 7.5 1.2e-06 28.9 0.1 4.0 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO30796.1 - 1.7e-18 65.2 10.8 0.0023 17.4 0.2 5.6 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.6 KOO30796.1 - 2.5e-11 43.3 2.5 4.4e-05 23.2 0.1 4.7 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO30796.1 - 0.0048 17.2 0.2 1.4 9.3 0.0 3.5 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region CstA_5TM PF13722.6 KOO30798.1 - 0.043 14.2 0.8 0.089 13.2 0.8 1.5 1 0 0 1 1 1 0 5TM C-terminal transporter carbon starvation CstA FlaC_arch PF05377.11 KOO30801.1 - 0.35 11.3 1.9 1.1 9.7 0.3 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) V_ATPase_I PF01496.19 KOO30801.1 - 2.7 5.8 4.1 3.1 5.6 4.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ras PF00071.22 KOO30802.1 - 4.5e-61 205.2 2.0 5.6e-61 204.9 2.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO30802.1 - 1.9e-35 121.7 0.4 3.9e-35 120.7 0.4 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO30802.1 - 3e-15 56.1 0.1 3.8e-15 55.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO30802.1 - 9.3e-08 32.1 0.6 3.2e-07 30.4 0.2 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO30802.1 - 8.7e-07 29.0 0.2 0.019 14.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOO30802.1 - 3.1e-06 26.9 0.9 3.1e-05 23.6 0.9 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KOO30802.1 - 0.00034 20.1 0.1 0.00052 19.5 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOO30802.1 - 0.00044 19.7 0.1 0.00054 19.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 KOO30802.1 - 0.00085 19.7 0.1 0.0015 19.0 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO30802.1 - 0.012 15.9 0.1 0.038 14.3 0.1 2.0 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 KOO30802.1 - 0.03 13.6 0.0 0.074 12.3 0.0 1.6 1 0 0 1 1 1 0 Septin ABC_tran PF00005.27 KOO30802.1 - 0.034 14.6 0.2 0.057 13.9 0.2 1.5 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 KOO30802.1 - 0.052 13.3 0.1 0.32 10.7 0.1 2.4 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 KOO30802.1 - 0.09 12.2 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_21 PF13304.6 KOO30802.1 - 0.17 11.6 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF3533 PF12051.8 KOO30802.1 - 0.68 8.8 3.1 0.93 8.3 2.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3533) SAC3_GANP PF03399.16 KOO30803.1 - 9.3e-55 186.1 0.3 1.3e-54 185.6 0.3 1.2 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 KOO30803.1 - 0.013 15.5 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family DSPc PF00782.20 KOO30804.1 - 3.2e-23 82.0 0.0 4.1e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOO30804.1 - 0.055 13.0 0.0 0.075 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF1877 PF08974.10 KOO30804.1 - 0.1 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) eIF-4B PF06273.11 KOO30804.1 - 0.11 11.6 0.5 0.25 10.4 0.7 1.4 2 0 0 2 2 2 0 Plant specific eukaryotic initiation factor 4B Acyl-CoA_dh_1 PF00441.24 KOO30805.1 - 4e-32 111.5 1.4 7.4e-32 110.6 1.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 KOO30805.1 - 8.9e-18 64.3 0.0 1.9e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KOO30805.1 - 7.9e-10 39.1 4.9 7.9e-10 39.1 4.9 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOO30805.1 - 1.2e-09 38.8 0.6 2.4e-09 37.8 0.2 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain DNA_ligase_A_C PF04679.15 KOO30805.1 - 0.045 14.3 0.0 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 ATP dependent DNA ligase C terminal region LRR_6 PF13516.6 KOO30806.1 - 2e-10 39.9 17.9 0.011 15.8 1.2 6.4 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.7 KOO30806.1 - 0.098 13.1 5.0 5.3 7.6 0.1 3.7 2 2 2 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO30806.1 - 0.1 12.4 4.1 18 5.2 0.0 4.4 5 1 0 5 5 5 0 Leucine rich repeat Na_H_Exchanger PF00999.21 KOO30807.1 - 7.5e-63 212.6 48.6 9.5e-63 212.3 48.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 KOO30807.1 - 2.2e-10 40.8 0.1 4.4e-10 39.8 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain 2-Hacid_dh_C PF02826.19 KOO30807.1 - 0.043 13.2 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Aminotran_1_2 PF00155.21 KOO30808.1 - 1.8e-18 66.8 0.0 3.3e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II FluMu_N PF17891.1 KOO30808.1 - 0.083 12.7 0.0 12 5.7 0.1 2.7 2 0 0 2 2 2 0 Mu-like prophage FluMu N-terminal domain WW PF00397.26 KOO30809.1 - 1.7e-10 40.8 0.2 2.9e-10 40.0 0.2 1.4 1 0 0 1 1 1 1 WW domain WD40 PF00400.32 KOO30810.1 - 3.1e-42 141.8 21.4 5.8e-09 36.4 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO30810.1 - 7.3e-11 42.2 0.2 0.3 11.4 0.0 4.8 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO30810.1 - 0.00022 20.3 4.2 0.66 8.9 0.1 4.4 2 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Golgin_A5 PF09787.9 KOO30810.1 - 0.0017 17.9 0.7 0.0027 17.2 0.7 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 PALB2_WD40 PF16756.5 KOO30810.1 - 0.026 13.5 4.9 0.17 10.8 0.3 3.2 2 1 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain eIF2A PF08662.11 KOO30810.1 - 0.031 14.2 0.0 0.46 10.3 0.0 2.4 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOO30810.1 - 0.04 12.6 8.9 5.7 5.5 0.1 5.1 3 1 3 6 6 6 0 Nucleoporin Nup120/160 DUF3585 PF12130.8 KOO30810.1 - 2.9 8.0 8.2 0.41 10.8 2.5 2.0 1 1 1 2 2 2 0 Bivalent Mical/EHBP Rab binding domain Na_Ca_ex PF01699.24 KOO30811.1 - 3e-36 124.7 43.2 8e-18 64.8 19.9 2.8 2 1 0 2 2 2 2 Sodium/calcium exchanger protein HECT PF00632.25 KOO30812.1 - 4.1e-48 164.4 0.0 6.1e-48 163.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBA PF00627.31 KOO30812.1 - 5.5e-10 39.0 1.2 0.00032 20.5 0.2 3.4 4 0 0 4 4 4 2 UBA/TS-N domain UBA_4 PF14555.6 KOO30812.1 - 0.013 15.3 0.1 0.054 13.3 0.0 2.1 2 0 0 2 2 2 0 UBA-like domain zf-RING_5 PF14634.6 KOO30813.1 - 1e-05 25.4 5.1 1.7e-05 24.7 5.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOO30813.1 - 0.00011 22.0 6.9 0.00023 21.0 6.9 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO30813.1 - 0.00078 19.3 5.4 0.002 17.9 5.4 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO30813.1 - 0.0025 17.8 1.8 0.0042 17.1 1.2 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.6 KOO30813.1 - 0.005 16.7 2.6 0.0087 15.9 2.6 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 KOO30813.1 - 0.014 15.3 3.5 0.022 14.6 3.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO30813.1 - 0.029 14.7 6.7 0.064 13.6 6.7 1.6 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 KOO30813.1 - 0.086 12.7 6.1 0.18 11.7 6.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn-ribbon_8 PF09723.10 KOO30813.1 - 0.15 12.2 1.3 0.33 11.1 1.3 1.6 1 0 0 1 1 1 0 Zinc ribbon domain zf-RING_10 PF16685.5 KOO30813.1 - 0.22 11.7 3.1 0.46 10.7 3.1 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 KOO30813.1 - 0.44 10.7 4.4 1.2 9.3 4.4 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Mad3_BUB1_I PF08311.12 KOO30814.1 - 1.7e-10 40.9 0.0 6.5e-10 39.1 0.0 1.8 1 1 1 2 2 2 1 Mad3/BUB1 homology region 1 Aldo_ket_red PF00248.21 KOO30815.1 - 1.2e-55 188.8 0.0 1.5e-55 188.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Hexapep PF00132.24 KOO30817.1 - 0.15 11.9 0.1 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) DUF563 PF04577.14 KOO30820.1 - 2.6e-05 24.5 0.1 3.6e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) PDZ PF00595.24 KOO30821.1 - 0.0073 16.6 0.1 0.014 15.7 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO30821.1 - 0.081 12.8 0.1 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 PDZ domain Macro PF01661.21 KOO30822.1 - 2.6e-12 46.8 0.0 3.7e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Macro domain EF-hand_6 PF13405.6 KOO30825.1 - 9.6e-05 22.0 0.4 0.00026 20.7 0.4 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO30825.1 - 0.00047 19.5 0.2 0.00098 18.5 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO30825.1 - 0.024 14.1 0.8 0.057 12.9 0.8 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO30825.1 - 0.039 14.4 0.4 0.082 13.4 0.4 1.5 1 0 0 1 1 1 0 EF-hand domain pair DUF1772 PF08592.11 KOO30825.1 - 0.098 13.0 0.3 2 8.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) HTH_28 PF13518.6 KOO30827.1 - 0.04 14.1 4.5 0.21 11.7 2.9 3.2 2 1 1 3 3 3 0 Helix-turn-helix domain TPR_12 PF13424.6 KOO30827.1 - 0.13 12.6 3.0 0.63 10.4 3.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TilS PF09179.11 KOO30827.1 - 0.67 10.5 6.2 14 6.3 0.1 3.5 3 0 0 3 3 3 0 TilS substrate binding domain XPG_I PF00867.18 KOO30828.1 - 3.5e-16 59.3 0.0 6.5e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 KOO30828.1 - 1.9e-15 57.2 0.0 3.4e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 KOO30828.1 - 6.4e-06 25.8 0.0 9e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing JmjC PF02373.22 KOO30829.1 - 4.5e-13 49.6 0.0 1.1e-12 48.4 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Chromo PF00385.24 KOO30829.1 - 3.1e-06 27.0 2.1 3.1e-06 27.0 2.1 1.7 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain NAD_binding_1 PF00175.21 KOO30830.1 - 1.4e-13 51.5 0.0 2.3e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOO30830.1 - 0.029 14.5 0.2 0.61 10.2 0.0 2.2 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Pkinase PF00069.25 KOO30831.1 - 2.4e-26 92.7 0.0 4.4e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30831.1 - 7.6e-26 90.9 0.0 1.3e-25 90.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CRC_subunit PF08624.10 KOO30831.1 - 0.13 12.7 0.0 1.6 9.2 0.0 2.3 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit SAP PF02037.27 KOO30832.1 - 5.7e-07 29.1 0.0 1.3e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 SAP domain Chromo PF00385.24 KOO30832.1 - 1.2e-06 28.3 1.4 2.5e-06 27.3 1.4 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CENP-Q PF13094.6 KOO30833.1 - 0.16 12.2 1.6 0.21 11.8 1.6 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit MLD PF11647.8 KOO30834.1 - 0.69 10.2 2.6 44 4.4 0.0 3.5 3 0 0 3 3 3 0 Membrane Localization Domain T4_Rnl2_C PF18043.1 KOO30834.1 - 0.7 10.1 2.7 2.9 8.1 0.1 2.8 3 0 0 3 3 3 0 T4 RNA ligase 2 C-terminal EF-hand_1 PF00036.32 KOO30835.1 - 2e-05 23.8 0.1 3.9e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO30835.1 - 4.3e-05 23.1 0.1 9.5e-05 22.0 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO30835.1 - 0.0046 16.4 0.1 0.0088 15.5 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO30835.1 - 0.0079 16.6 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair AAA_28 PF13521.6 KOO30836.1 - 2.5e-16 60.3 0.0 1.4e-15 57.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 KOO30836.1 - 0.0076 15.3 0.1 0.016 14.2 0.1 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SET PF00856.28 KOO30837.1 - 1.5e-06 28.7 0.0 7.2e-06 26.5 0.0 1.9 1 1 0 1 1 1 1 SET domain SAF PF08666.12 KOO30837.1 - 0.05 14.2 1.2 5.2 7.8 0.0 2.8 3 0 0 3 3 3 0 SAF domain U-box PF04564.15 KOO30840.1 - 1.2e-12 47.8 0.0 2.2e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO30840.1 - 5.1e-11 42.9 11.2 5.5e-06 26.9 1.0 3.6 3 0 0 3 3 3 2 Sel1 repeat zf-NOSIP PF15906.5 KOO30840.1 - 0.004 17.3 0.0 0.0098 16.0 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO30840.1 - 0.0062 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Pkinase PF00069.25 KOO30842.1 - 5.1e-63 212.9 0.0 6.3e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30842.1 - 1.1e-43 149.4 0.0 1.7e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO30842.1 - 0.00063 18.6 0.0 0.0013 17.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO30842.1 - 0.044 13.1 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 KOO30842.1 - 0.044 13.4 0.1 2.9 7.5 0.0 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 His_Phos_1 PF00300.22 KOO30843.1 - 2.2e-11 43.8 0.0 6.8e-08 32.4 0.0 2.3 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Pkinase PF00069.25 KOO30844.1 - 1.7e-45 155.5 0.0 9.6e-45 153.0 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO30844.1 - 1.1e-27 97.0 0.0 9.1e-16 57.9 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 KOO30844.1 - 5.1e-05 23.3 0.2 5.1e-05 23.3 0.2 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 KOO30844.1 - 0.0062 16.2 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 KOO30844.1 - 0.009 15.4 0.0 0.022 14.1 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO30844.1 - 0.0094 14.8 0.0 0.016 14.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase YukC PF10140.9 KOO30844.1 - 0.011 14.6 0.0 0.015 14.2 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC RIO1 PF01163.22 KOO30844.1 - 0.065 12.8 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 KOO30844.1 - 0.1 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOO30844.1 - 0.15 11.0 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain EF-hand_6 PF13405.6 KOO30845.1 - 4.2e-14 51.2 5.3 0.00022 20.9 0.2 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO30845.1 - 1.6e-12 46.0 7.0 0.0012 18.2 0.5 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO30845.1 - 1.7e-10 40.5 3.5 0.00037 20.3 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO30845.1 - 3.1e-09 37.1 5.2 0.0013 19.1 0.1 3.6 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO30845.1 - 7.2e-07 28.4 6.3 0.083 12.4 0.2 4.4 4 0 0 4 4 4 3 EF hand Fib_alpha PF08702.10 KOO30845.1 - 2.2 8.5 7.7 2.5 8.3 2.0 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family MDM10 PF12519.8 KOO30845.1 - 4.5 6.0 7.4 7.7 5.3 7.4 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 YabA PF06156.13 KOO30845.1 - 4.7 7.9 12.1 15 6.3 7.7 3.1 2 1 0 2 2 2 0 Initiation control protein YabA PALP PF00291.25 KOO30846.1 - 1.5e-61 208.4 0.0 2e-61 208.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Glutaredoxin PF00462.24 KOO30846.1 - 4.7e-11 42.8 0.0 1e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin Abhydrolase_6 PF12697.7 KOO30846.1 - 0.048 14.2 1.6 0.11 13.1 1.2 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family CMD PF02627.20 KOO30847.1 - 0.0032 17.5 0.0 0.01 15.9 0.0 1.9 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family N6-adenineMlase PF10237.9 KOO30848.1 - 2.2e-18 66.6 0.0 4.7e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase PDZ PF00595.24 KOO30848.1 - 8.7e-09 35.6 1.1 0.31 11.4 0.0 3.9 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KOO30848.1 - 9.6e-09 35.5 0.7 0.24 11.8 0.1 3.7 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KOO30848.1 - 3.4e-07 30.0 0.2 0.49 10.3 0.0 4.3 4 0 0 4 4 4 3 PDZ domain EF-hand_7 PF13499.6 KOO30848.1 - 0.00012 22.4 5.4 0.00032 21.1 5.4 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO30848.1 - 0.00021 20.6 2.6 0.064 12.8 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO30848.1 - 0.0072 16.1 4.3 0.015 15.1 3.4 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO30848.1 - 0.029 13.9 0.3 0.029 13.9 0.3 2.3 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 KOO30848.1 - 0.068 13.1 1.8 0.83 9.7 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain Glyco_hydro_79n PF03662.14 KOO30849.1 - 1e-23 83.8 0.0 3.3e-15 55.8 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 79, N-terminal domain BAF PF02961.14 KOO30850.1 - 1.1e-16 61.0 0.1 3.3e-07 30.6 0.0 3.9 4 0 0 4 4 4 3 Barrier to autointegration factor HHH_5 PF14520.6 KOO30850.1 - 0.063 13.9 0.3 37 5.0 0.0 3.2 3 0 0 3 3 3 0 Helix-hairpin-helix domain Patatin PF01734.22 KOO30853.1 - 0.046 13.9 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 Patatin-like phospholipase DUF4253 PF14062.6 KOO30854.1 - 0.0099 16.0 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4253) DUF4381 PF14316.6 KOO30855.1 - 0.09 13.0 0.2 0.22 11.8 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4381) TFIIE-A_C PF11521.8 KOO30856.1 - 1e-09 38.5 0.5 2.6e-09 37.3 0.5 1.7 1 0 0 1 1 1 1 C-terminal general transcription factor TFIIE alpha TFIIE_alpha PF02002.17 KOO30856.1 - 0.00064 19.5 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 TFIIE alpha subunit MarR_2 PF12802.7 KOO30856.1 - 0.0095 15.8 0.3 0.03 14.2 0.3 1.9 1 1 0 1 1 1 1 MarR family Methyltransf_13 PF08421.11 KOO30856.1 - 0.16 12.2 0.1 0.36 11.1 0.1 1.6 1 0 0 1 1 1 0 Putative zinc binding domain HATPase_c PF02518.26 KOO30857.1 - 2.7e-15 56.8 0.9 5.5e-15 55.8 0.2 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOO30857.1 - 1.2e-14 54.4 0.0 3.1e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Hpt PF01627.23 KOO30857.1 - 7.5e-07 29.3 0.3 2.1e-06 27.9 0.3 1.8 1 0 0 1 1 1 1 Hpt domain HATPase_c_3 PF13589.6 KOO30857.1 - 0.0084 15.9 0.0 0.023 14.5 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase rve PF00665.26 KOO30859.1 - 8.2e-10 38.9 0.1 1.5e-09 38.1 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain ART PF01129.18 KOO30860.1 - 8.2e-08 31.8 1.6 1.2e-06 28.0 0.0 3.0 3 0 0 3 3 3 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO30860.1 - 1.7e-07 30.8 0.0 3.9e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme PA26 PF04636.13 KOO30860.1 - 0.39 9.6 4.6 0.62 8.9 4.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FAST_1 PF06743.15 KOO30861.1 - 4.1e-07 29.8 0.0 3.4 7.7 0.0 5.4 5 1 2 7 7 7 4 FAST kinase-like protein, subdomain 1 DUF3486 PF11985.8 KOO30861.1 - 0.062 13.7 1.1 0.12 12.8 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3486) Vps55 PF04133.14 KOO30862.1 - 2.1e-17 63.2 10.1 2.3e-17 63.0 10.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF3397 PF11877.8 KOO30862.1 - 0.016 15.4 2.8 0.016 15.4 2.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3397) Hanta_G2 PF01561.16 KOO30862.1 - 0.45 9.1 2.6 0.64 8.6 2.6 1.2 1 0 0 1 1 1 0 Hantavirus glycoprotein G2 EF-hand_7 PF13499.6 KOO30863.1 - 6.6e-19 68.1 0.0 2e-08 34.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO30863.1 - 5.5e-17 60.2 1.2 0.00017 21.3 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO30863.1 - 3.3e-15 54.4 0.2 0.00032 20.0 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 KOO30863.1 - 8e-12 44.1 0.7 0.0019 17.6 0.0 4.3 4 0 0 4 4 4 2 EF hand GPS PF01825.21 KOO30863.1 - 2e-08 34.6 4.4 4.3e-08 33.5 4.4 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EF-hand_8 PF13833.6 KOO30863.1 - 0.00048 19.9 0.4 1.1 9.2 0.0 3.9 2 2 2 4 4 4 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO30863.1 - 0.0024 18.1 0.0 1.5 9.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain HEPN_LA2681 PF18733.1 KOO30863.1 - 0.044 13.1 0.1 8.6 5.6 0.0 2.2 1 1 1 2 2 2 0 LA2681-like HEPN LRR_6 PF13516.6 KOO30865.1 - 5.3e-15 54.1 13.8 0.0092 16.0 0.0 7.5 8 0 0 8 8 8 4 Leucine Rich repeat LRR_4 PF12799.7 KOO30865.1 - 0.00024 21.4 0.0 64 4.2 0.0 5.1 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO30865.1 - 0.00071 19.8 0.1 96 4.2 0.0 5.3 5 1 0 5 5 5 0 Leucine Rich Repeat Ecm33 PF12454.8 KOO30865.1 - 0.013 15.6 3.7 0.23 11.6 0.1 3.8 4 0 0 4 4 4 0 GPI-anchored cell wall organization protein LRR_8 PF13855.6 KOO30865.1 - 0.059 13.2 0.0 86 3.0 0.0 4.5 5 0 0 5 5 5 0 Leucine rich repeat Branch PF02485.21 KOO30866.1 - 1e-21 77.6 0.1 1e-13 51.4 0.0 2.1 1 1 1 2 2 2 2 Core-2/I-Branching enzyme NolV PF06635.12 KOO30866.1 - 0.023 14.1 0.0 0.056 12.8 0.0 1.6 1 0 0 1 1 1 0 Nodulation protein NolV WWE PF02825.20 KOO30867.1 - 2.6e-05 24.7 0.1 0.0052 17.3 0.1 2.9 2 1 0 2 2 2 1 WWE domain CBM_25 PF03423.13 KOO30867.1 - 0.062 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) HTH_1 PF00126.27 KOO30867.1 - 0.074 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Lipase_GDSL_2 PF13472.6 KOO30868.1 - 2.6e-29 102.9 0.0 5.1e-29 101.9 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KOO30868.1 - 1.4e-23 84.0 0.0 1.7e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase WWE PF02825.20 KOO30869.1 - 3.9e-13 49.8 0.1 7e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 WWE domain UBA PF00627.31 KOO30869.1 - 0.032 14.2 0.3 0.091 12.7 0.2 1.8 2 0 0 2 2 2 0 UBA/TS-N domain PSD4 PF07631.11 KOO30870.1 - 0.031 14.8 0.2 0.049 14.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) rve PF00665.26 KOO30871.1 - 0.00011 22.3 0.0 0.00028 21.0 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain DHHC PF01529.20 KOO30873.1 - 8.3e-13 48.6 9.7 8.3e-13 48.6 9.7 2.5 2 0 0 2 2 2 2 DHHC palmitoyltransferase Thiolase_N PF00108.23 KOO30877.1 - 2.1e-50 171.5 9.2 4.9e-50 170.3 9.2 1.6 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOO30877.1 - 1.3e-42 144.3 0.3 1.3e-42 144.3 0.3 2.4 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KOO30877.1 - 0.024 14.2 3.9 0.33 10.5 1.5 3.2 2 1 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain BLOC1S3 PF15753.5 KOO30878.1 - 0.026 14.7 3.2 0.03 14.5 3.2 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 CCDC144C PF14915.6 KOO30878.1 - 0.062 12.4 8.3 0.11 11.5 8.4 1.6 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region PhoU PF01895.19 KOO30878.1 - 0.063 13.7 3.6 0.12 12.9 3.6 1.5 1 0 0 1 1 1 0 PhoU domain Fez1 PF06818.15 KOO30878.1 - 0.6 10.5 7.2 0.76 10.2 7.2 1.2 1 0 0 1 1 1 0 Fez1 FUSC PF04632.12 KOO30878.1 - 2.2 6.7 13.9 2.7 6.4 13.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3450 PF11932.8 KOO30878.1 - 2.3 7.5 12.5 0.42 9.9 4.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Kinesin PF00225.23 KOO30879.1 - 7.8e-53 179.5 0.2 1.7e-25 89.7 0.5 2.1 1 1 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KOO30879.1 - 1.4e-16 60.7 0.0 1.5e-15 57.4 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding Adenylsucc_synt PF00709.21 KOO30880.1 - 0.79 8.6 2.8 0.4 9.5 0.1 1.7 2 0 0 2 2 2 0 Adenylosuccinate synthetase Golgin_A5 PF09787.9 KOO30881.1 - 0.005 16.4 2.6 0.005 16.4 2.6 2.2 2 0 0 2 2 2 1 Golgin subfamily A member 5 ERM PF00769.19 KOO30881.1 - 0.14 11.9 34.3 0.6 9.9 7.6 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Spc7 PF08317.11 KOO30881.1 - 0.22 10.4 25.9 0.14 11.0 8.6 2.5 2 1 0 2 2 2 0 Spc7 kinetochore protein IFT57 PF10498.9 KOO30881.1 - 1.1 8.2 13.1 0.014 14.4 3.8 1.9 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 FapA PF03961.13 KOO30881.1 - 8.3 4.9 10.7 0.27 9.8 0.7 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A PFK PF00365.20 KOO30883.1 - 1.1e-59 202.1 0.8 1.6e-59 201.6 0.8 1.2 1 0 0 1 1 1 1 Phosphofructokinase NAD_kinase PF01513.21 KOO30883.1 - 0.059 12.6 0.1 0.1 11.7 0.1 1.3 1 0 0 1 1 1 0 ATP-NAD kinase DAGK_cat PF00781.24 KOO30883.1 - 0.059 13.0 0.2 0.059 13.0 0.2 2.4 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain Choline_transpo PF04515.12 KOO30884.1 - 1.7e-48 165.5 41.4 2.5e-48 165.0 32.3 2.3 1 1 0 2 2 2 2 Plasma-membrane choline transporter Fungus-induced PF10917.8 KOO30884.1 - 4.6 7.6 10.3 27 5.2 0.2 3.9 3 0 0 3 3 3 0 Fungus-induced protein Thioredoxin PF00085.20 KOO30885.1 - 2e-15 56.6 0.1 4.5e-15 55.5 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin EF-hand_6 PF13405.6 KOO30885.1 - 1.3e-11 43.4 0.1 0.00056 19.6 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO30885.1 - 1.1e-07 30.8 0.0 0.027 14.0 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO30885.1 - 2.2e-07 31.2 0.1 0.034 14.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO30885.1 - 2e-06 27.0 0.2 0.088 12.3 0.0 2.6 2 0 0 2 2 2 2 EF hand Thioredoxin_8 PF13905.6 KOO30885.1 - 0.00011 22.4 0.1 0.00023 21.4 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like EF-hand_8 PF13833.6 KOO30885.1 - 0.00022 21.0 0.2 0.5 10.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair Thioredoxin_2 PF13098.6 KOO30885.1 - 0.0042 17.5 0.1 0.011 16.1 0.1 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 KOO30885.1 - 0.016 15.1 0.1 0.033 14.1 0.1 1.4 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 KOO30885.1 - 0.09 12.5 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Redoxin DUF2866 PF11065.8 KOO30885.1 - 0.13 12.3 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2866) EF-hand_7 PF13499.6 KOO30886.1 - 3.7e-40 136.2 17.1 5.7e-14 52.3 2.4 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO30886.1 - 1e-39 131.0 24.2 7.4e-07 28.6 0.4 6.3 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.32 KOO30886.1 - 1.6e-39 130.5 26.1 2.3e-07 29.9 0.4 6.3 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.6 KOO30886.1 - 1.1e-35 119.6 30.7 1.1e-07 31.0 0.4 6.3 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.6 KOO30886.1 - 9e-21 73.5 29.5 1.3e-06 28.1 1.9 6.1 3 3 3 6 6 6 6 EF-hand domain pair Caleosin PF05042.13 KOO30886.1 - 5.9e-06 26.3 9.8 1.5 8.7 0.1 6.0 5 2 1 7 7 7 2 Caleosin related protein EF-hand_9 PF14658.6 KOO30886.1 - 8.5e-06 26.0 0.0 0.64 10.4 0.0 4.8 5 1 1 6 6 5 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO30886.1 - 2.3e-05 24.7 8.5 0.45 10.8 0.2 5.2 1 1 3 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO30886.1 - 5e-05 23.2 4.6 2.8 8.0 0.0 4.2 2 1 0 4 4 4 2 Cytoskeletal-regulatory complex EF hand DUF2744 PF10910.8 KOO30886.1 - 0.00049 20.1 0.0 5.5 7.0 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF2744) EF-hand_14 PF17959.1 KOO30886.1 - 0.0048 17.2 3.7 12 6.3 0.1 5.1 6 0 0 6 6 6 0 EF-hand domain ART PF01129.18 KOO30886.1 - 0.0099 15.2 7.5 1.3 8.3 0.1 3.0 3 0 0 3 3 3 2 NAD:arginine ADP-ribosyltransferase XS PF03468.14 KOO30886.1 - 0.025 14.9 6.1 0.15 12.4 1.2 3.1 3 1 0 3 3 3 0 XS domain Dockerin_1 PF00404.18 KOO30886.1 - 0.026 14.7 6.9 9.9 6.4 0.0 4.2 3 3 1 4 4 4 0 Dockerin type I domain Ad_Cy_reg PF16701.5 KOO30886.1 - 0.039 13.7 0.0 11 5.7 0.0 2.9 3 0 0 3 3 3 0 Adenylate cyclase regulatory domain DUF2780 PF11075.8 KOO30886.1 - 0.082 13.0 0.2 28 4.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function VcgC/VcgE (DUF2780) Imm40 PF15569.6 KOO30886.1 - 0.1 12.7 0.0 0.56 10.4 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 40 DUF1062 PF06353.12 KOO30886.1 - 0.18 12.6 0.6 46 4.8 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1062) Barwin PF00967.17 KOO30886.1 - 0.24 11.3 2.9 24 4.8 0.0 3.8 3 2 2 5 5 5 0 Barwin family VCBS PF13517.6 KOO30886.1 - 0.77 10.4 0.0 0.77 10.4 0.0 4.6 6 0 0 6 6 6 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Glyco_hydro_31 PF01055.26 KOO30887.1 - 2.3e-140 468.7 6.1 2.9e-140 468.3 6.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 KOO30887.1 - 6e-18 64.9 0.3 2.3e-17 63.1 0.1 2.2 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 KOO30887.1 - 6.6e-06 26.3 0.1 2.2e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) LRR_5 PF13306.6 KOO30888.1 - 1.5e-47 160.7 0.0 3.6e-26 91.6 0.0 2.1 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO30888.1 - 1.8e-07 30.8 0.0 0.059 13.1 0.0 3.9 3 1 2 5 5 5 3 Leucine rich repeat PilA4 PF18682.1 KOO30888.1 - 0.19 12.1 4.5 7 7.1 0.1 4.2 2 1 3 5 5 5 0 Pilin A4 LETM1 PF07766.13 KOO30889.1 - 1e-78 264.4 10.3 4.6e-44 150.8 2.8 2.5 1 1 1 2 2 2 2 LETM1-like protein EF-hand_7 PF13499.6 KOO30889.1 - 7.1e-11 42.4 0.0 1.9e-09 37.8 0.0 3.2 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO30889.1 - 7.5e-10 37.6 1.3 0.00055 19.3 0.1 3.0 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO30889.1 - 8.6e-10 37.7 0.5 0.00058 19.2 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO30889.1 - 7.5e-09 34.8 0.6 0.00071 19.3 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO30889.1 - 4.3e-06 26.5 1.1 0.093 12.6 0.2 3.2 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO30889.1 - 0.0018 18.6 0.0 0.0018 18.6 0.0 2.4 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region PG_binding_1 PF01471.18 KOO30889.1 - 0.014 15.5 0.0 0.04 14.1 0.0 1.8 1 0 0 1 1 1 0 Putative peptidoglycan binding domain HEAT PF02985.22 KOO30890.1 - 9.5e-07 28.6 0.7 0.11 12.8 0.0 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 KOO30890.1 - 1.7e-06 28.3 2.1 0.0098 16.3 0.0 4.1 3 2 0 3 3 3 2 HEAT repeats DUF4042 PF13251.6 KOO30890.1 - 0.046 13.4 0.0 0.72 9.5 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4042) HEAT_PBS PF03130.16 KOO30890.1 - 0.4 11.5 4.3 6.2 7.8 0.3 3.6 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat HEAT PF02985.22 KOO30891.1 - 1.4e-09 37.4 8.6 0.085 13.2 0.0 5.5 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 KOO30891.1 - 1.4e-05 25.4 3.6 0.89 10.0 0.0 4.5 3 1 1 4 4 4 3 HEAT repeats HEAT_EZ PF13513.6 KOO30891.1 - 0.032 14.7 8.7 8.4 7.0 0.0 4.8 5 0 0 5 5 5 0 HEAT-like repeat baeRF_family2 PF18844.1 KOO30891.1 - 0.16 12.1 0.1 0.42 10.7 0.1 1.6 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 2 2OG-FeII_Oxy_3 PF13640.6 KOO30892.1 - 6.2e-08 33.4 0.0 1.6e-07 32.1 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2163 PF09931.9 KOO30892.1 - 0.012 15.8 0.0 0.018 15.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2163) PfkB PF00294.24 KOO30893.1 - 7.8e-25 87.8 0.1 1.2e-24 87.2 0.1 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase EccE PF11203.8 KOO30893.1 - 0.17 12.2 0.2 0.17 12.2 0.2 2.4 1 1 1 2 2 2 0 Putative type VII ESX secretion system translocon, EccE Glyco_transf_34 PF05637.12 KOO30894.1 - 0.00051 19.8 1.7 0.78 9.4 0.2 2.5 2 0 0 2 2 2 2 galactosyl transferase GMA12/MNN10 family MHB PF16525.5 KOO30894.1 - 0.019 15.2 0.0 6.1 7.2 0.0 3.3 3 0 0 3 3 3 0 Haemophore, haem-binding DUF2237 PF09996.9 KOO30895.1 - 2.9e-11 43.3 2.8 5.4e-11 42.5 2.8 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2237) DMRT-like PF15791.5 KOO30895.1 - 0.29 11.6 3.6 0.8 10.1 3.6 1.7 1 0 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 GST_N_3 PF13417.6 KOO30896.1 - 1.3e-07 31.9 0.0 2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KOO30896.1 - 2.3e-07 31.0 0.0 3.8e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO30896.1 - 3e-06 27.1 0.7 6.1e-06 26.2 0.7 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KOO30896.1 - 8.9e-05 22.7 0.0 0.00016 21.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOO30896.1 - 0.00052 20.2 0.0 0.00088 19.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOO30896.1 - 0.011 15.9 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain RRM_1 PF00076.22 KOO30897.1 - 1.4e-15 56.9 0.0 2.1e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOO30897.1 - 6.1e-06 25.8 0.0 7.1e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MazE_antitoxin PF04014.18 KOO30897.1 - 0.12 12.4 0.3 18 5.4 0.0 2.3 2 0 0 2 2 2 0 Antidote-toxin recognition MazE, bacterial antitoxin L51_S25_CI-B8 PF05047.16 KOO30900.1 - 1.5e-08 34.4 0.0 1.9e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DNA_primase_S PF01896.19 KOO30901.1 - 5.2e-45 153.7 0.0 7.1e-45 153.2 0.0 1.2 1 0 0 1 1 1 1 DNA primase small subunit Histone PF00125.24 KOO30902.1 - 1.7e-39 135.2 0.5 2e-39 135.0 0.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KOO30902.1 - 4.8e-05 23.4 0.0 6.1e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KOO30902.1 - 0.0018 18.6 0.1 0.0024 18.2 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 KOO30902.1 - 0.0032 17.5 0.0 0.0039 17.2 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 KOO30902.1 - 0.009 16.3 0.7 0.014 15.6 0.7 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 KOO30902.1 - 0.04 14.1 0.3 0.071 13.3 0.3 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) XPG_N PF00752.17 KOO30904.1 - 1.3e-20 73.8 0.0 2.1e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KOO30904.1 - 6.4e-19 68.1 0.0 1.9e-18 66.6 0.0 1.9 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 KOO30904.1 - 1.6e-08 34.3 0.3 2.5e-08 33.7 0.3 1.2 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 KOO30904.1 - 0.0098 16.5 0.0 0.028 15.0 0.0 1.7 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 KOO30904.1 - 0.045 14.4 0.0 0.13 12.8 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain HEAT PF02985.22 KOO30905.1 - 6.4e-12 44.7 31.1 0.32 11.4 0.1 12.3 11 0 0 11 11 11 5 HEAT repeat Telomere_reg-2 PF10193.9 KOO30905.1 - 0.0087 16.5 0.1 0.059 13.8 0.1 2.5 1 0 0 1 1 1 1 Telomere length regulation protein RTP1_C1 PF10363.9 KOO30905.1 - 0.037 14.2 0.0 7 6.9 0.0 3.5 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 KOO30905.1 - 0.12 11.0 0.2 1.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Adaptin N terminal region IMS PF00817.20 KOO30906.1 - 2.5e-18 66.5 0.0 3.5e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 impB/mucB/samB family Ribosomal_L30_N PF08079.12 KOO30907.1 - 2.9e-22 78.7 15.1 4.4e-22 78.1 15.1 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 KOO30907.1 - 1.3e-12 47.4 0.5 3.9e-12 45.9 0.5 1.8 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF908 PF06012.12 KOO30907.1 - 0.0044 16.5 0.1 0.006 16.1 0.1 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) adh_short PF00106.25 KOO30908.1 - 4.4e-27 94.8 4.6 2e-24 86.1 0.6 2.4 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO30908.1 - 2.3e-13 50.2 7.8 4.9e-13 49.2 1.5 2.4 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO30908.1 - 1.1e-05 25.4 0.9 2.3e-05 24.4 0.9 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOO30908.1 - 0.025 14.0 0.1 0.074 12.5 0.1 1.8 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family RNA_pol_L_2 PF13656.6 KOO30909.1 - 6.1e-25 86.8 0.0 7.4e-25 86.5 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KOO30909.1 - 1.6e-07 30.7 0.0 2.2e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SbmA_BacA PF05992.12 KOO30910.1 - 3.6e-32 112.1 0.0 4e-32 111.9 0.0 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.15 KOO30910.1 - 8e-08 32.0 0.0 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 Ecotin PF03974.13 KOO30912.1 - 6.8e-37 126.2 0.0 1.1e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 Ecotin GFO_IDH_MocA PF01408.22 KOO30912.1 - 1.8e-12 48.1 0.1 4e-12 47.0 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DHC_N1 PF08385.12 KOO30915.1 - 5.8e-182 606.3 12.7 5.8e-182 606.3 12.7 3.0 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 KOO30915.1 - 4.9e-119 398.0 2.8 4.9e-119 398.0 2.8 3.6 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 KOO30915.1 - 1.4e-115 385.7 0.5 1.7e-108 362.5 0.1 2.6 1 1 1 2 2 2 2 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 KOO30915.1 - 1.9e-45 154.6 3.9 2.1e-40 138.2 0.1 4.4 5 0 0 5 5 5 2 P-loop containing dynein motor region AAA_lid_1 PF17857.1 KOO30915.1 - 1.2e-18 67.2 0.0 6e-18 64.9 0.0 2.3 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 KOO30915.1 - 1.6e-16 60.6 0.7 1.1e-15 57.9 0.1 2.9 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_8 PF12780.7 KOO30915.1 - 3.4e-16 59.4 2.0 1.5e-15 57.2 0.6 3.0 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_5 PF07728.14 KOO30915.1 - 1.8e-10 40.9 4.4 0.01 15.8 0.0 5.8 4 2 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA PF00004.29 KOO30915.1 - 1.8e-05 25.1 4.3 0.7 10.3 0.0 4.2 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOO30915.1 - 0.001 19.3 6.9 0.071 13.4 0.0 5.1 5 0 0 5 5 5 1 AAA domain AAA_19 PF13245.6 KOO30915.1 - 0.0012 19.2 4.6 0.31 11.4 0.0 4.1 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KOO30915.1 - 0.017 15.5 0.0 0.017 15.5 0.0 5.7 5 2 1 6 6 6 0 AAA ATPase domain AAA_29 PF13555.6 KOO30915.1 - 0.031 14.0 0.1 12 5.7 0.0 2.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_24 PF13479.6 KOO30915.1 - 0.079 12.7 0.6 6.2 6.5 0.0 3.6 4 0 0 4 4 4 0 AAA domain RNA_helicase PF00910.22 KOO30915.1 - 0.12 12.7 0.3 5.7 7.4 0.0 3.4 3 0 0 3 3 2 0 RNA helicase AAA_33 PF13671.6 KOO30915.1 - 0.15 12.3 6.1 0.22 11.7 0.0 4.1 4 1 0 4 4 4 0 AAA domain CCDC-167 PF15188.6 KOO30915.1 - 0.86 10.0 10.9 0.57 10.6 6.9 2.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 PDZ_6 PF17820.1 KOO30916.1 - 0.041 13.7 0.0 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 PDZ domain EF-hand_1 PF00036.32 KOO30917.1 - 1.2e-35 118.4 13.7 6.2e-10 37.9 2.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO30917.1 - 6.8e-32 109.7 4.8 2.7e-17 63.0 0.7 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO30917.1 - 9.1e-30 100.0 10.4 1.2e-07 31.1 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO30917.1 - 1.3e-25 87.7 11.7 6.2e-07 28.6 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO30917.1 - 8.9e-25 86.3 13.8 8.1e-14 51.2 2.1 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO30917.1 - 2.7e-13 50.0 0.4 8.1e-06 26.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO30917.1 - 4.9e-06 26.8 0.2 0.022 15.1 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO30917.1 - 0.00022 21.1 1.2 0.19 11.7 0.1 2.4 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand ERAP1_C PF11838.8 KOO30917.1 - 0.0021 17.7 0.0 0.0072 15.9 0.0 1.6 1 1 0 1 1 1 1 ERAP1-like C-terminal domain Caleosin PF05042.13 KOO30917.1 - 0.0077 16.2 2.6 4.1 7.3 0.1 3.3 1 1 3 4 4 4 1 Caleosin related protein EF-hand_11 PF08976.11 KOO30917.1 - 0.023 15.5 0.1 0.11 13.3 0.1 2.2 1 1 0 1 1 1 0 EF-hand domain DUF5640 PF18692.1 KOO30917.1 - 0.065 13.3 0.4 13 5.9 0.0 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5640) DUF2267 PF10025.9 KOO30917.1 - 0.11 12.7 0.1 0.22 11.8 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) PRK PF00485.18 KOO30918.1 - 2.6e-18 66.5 0.0 1.7e-17 63.9 0.0 1.9 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family T2SSE PF00437.20 KOO30918.1 - 0.022 13.9 0.0 0.041 12.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 KOO30918.1 - 0.024 15.0 0.0 0.073 13.4 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 KOO30918.1 - 0.028 14.7 0.0 0.13 12.5 0.0 2.2 1 1 1 2 2 2 0 AAA domain MobB PF03205.14 KOO30918.1 - 0.062 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 KOO30918.1 - 0.063 13.8 0.0 0.11 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 KOO30918.1 - 0.1 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_33 PF13671.6 KOO30918.1 - 0.1 12.7 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KOO30918.1 - 0.13 12.3 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRP54 PF00448.22 KOO30918.1 - 0.15 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain E2F_CC-MB PF16421.5 KOO30919.1 - 1.6e-30 105.3 0.0 2.5e-30 104.7 0.0 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 KOO30919.1 - 5.5e-25 87.2 0.0 1.1e-24 86.3 0.0 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 KOO30919.1 - 0.026 14.4 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Snapin_Pallidin PF14712.6 KOO30919.1 - 0.18 12.3 0.2 0.44 11.0 0.2 1.6 2 0 0 2 2 2 0 Snapin/Pallidin tRNA_synthFbeta PF17759.1 KOO30920.1 - 7.2e-45 153.0 0.0 1.1e-44 152.5 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 KOO30920.1 - 1.6e-32 111.6 0.0 1.6e-32 111.6 0.0 1.8 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 KOO30920.1 - 5.9e-21 74.9 0.0 1.1e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 KOO30920.1 - 4.8e-11 42.8 0.0 1.8e-09 37.8 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetase B5 domain RVT_2 PF07727.14 KOO30922.1 - 1.4e-08 34.7 0.0 2.4e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TAF4 PF05236.14 KOO30922.1 - 7.5 6.2 6.6 6.7 6.4 4.0 2.0 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family TarH PF02203.15 KOO30923.1 - 0.18 11.7 7.4 0.36 10.7 1.2 2.7 3 0 0 3 3 3 0 Tar ligand binding domain homologue ISG65-75 PF11727.8 KOO30923.1 - 0.72 9.0 6.0 1.3 8.2 6.0 1.3 1 0 0 1 1 1 0 Invariant surface glycoprotein RVT_2 PF07727.14 KOO30924.1 - 2e-09 37.5 0.0 3.2e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TUDOR_5 PF18359.1 KOO30924.1 - 0.002 17.8 0.0 0.0045 16.7 0.0 1.6 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 EF-hand_6 PF13405.6 KOO30926.1 - 2.8e-18 64.2 3.0 0.00078 19.2 0.2 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO30926.1 - 1.3e-17 62.0 4.6 0.0014 18.1 0.9 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO30926.1 - 4.5e-14 52.6 2.2 4.6e-06 27.0 0.2 4.4 3 2 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO30926.1 - 5.7e-11 41.4 5.9 0.0034 16.8 0.1 4.7 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO30926.1 - 4.4e-06 26.4 1.5 0.00062 19.6 0.1 3.8 3 1 1 4 4 4 1 EF-hand domain pair T2SSF PF00482.23 KOO30926.1 - 0.02 14.8 1.9 0.087 12.8 0.4 2.6 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Myb_DNA-binding PF00249.31 KOO30927.1 - 7.8e-07 29.2 0.2 1.9e-06 28.0 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain CUT PF02376.15 KOO30927.1 - 0.15 12.2 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 CUT domain DUF3792 PF12670.7 KOO30928.1 - 0.0083 16.3 0.1 0.0096 16.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3792) CS PF04969.16 KOO30929.1 - 7.4e-09 36.5 0.0 2.2e-08 35.0 0.0 1.8 2 0 0 2 2 2 1 CS domain Fibrillarin PF01269.17 KOO30930.1 - 7.4e-99 329.5 0.0 8.3e-99 329.3 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 KOO30930.1 - 4.6e-05 23.2 0.0 6.3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 KOO30930.1 - 0.0056 16.3 0.0 0.0085 15.8 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 KOO30930.1 - 0.14 11.9 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DHHC PF01529.20 KOO30931.1 - 2e-25 89.5 1.7 2.4e-25 89.2 1.7 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase AAA PF00004.29 KOO30932.1 - 8.7e-36 123.3 0.0 1.3e-35 122.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO30932.1 - 6.8e-10 38.6 0.1 1.7e-09 37.3 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain CDC37_C PF08564.10 KOO30932.1 - 4.5e-05 23.5 0.0 0.00013 22.0 0.0 1.7 2 0 0 2 2 1 1 Cdc37 C terminal domain Vps4_C PF09336.10 KOO30932.1 - 8.2e-05 22.5 0.0 0.00018 21.4 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.14 KOO30932.1 - 0.00035 20.6 0.1 0.003 17.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO30932.1 - 0.00065 20.1 0.0 0.0017 18.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 KOO30932.1 - 0.0014 18.0 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 KOO30932.1 - 0.0027 17.8 0.0 0.0048 17.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 KOO30932.1 - 0.011 15.9 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KOO30932.1 - 0.014 14.8 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 KOO30932.1 - 0.015 15.6 0.1 0.082 13.2 0.0 2.0 1 1 1 2 2 2 0 AAA domain RuvB_N PF05496.12 KOO30932.1 - 0.016 15.0 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 KOO30932.1 - 0.023 14.4 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOO30932.1 - 0.028 15.0 0.0 0.062 13.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF1080 PF06439.11 KOO30932.1 - 0.031 14.4 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) IstB_IS21 PF01695.17 KOO30932.1 - 0.033 13.9 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 KOO30932.1 - 0.047 13.7 0.0 0.078 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KOO30932.1 - 0.049 14.0 0.0 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 RNA helicase DUF2944 PF11161.8 KOO30932.1 - 0.15 11.9 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) FAD_binding_3 PF01494.19 KOO30933.1 - 3.8e-10 39.5 0.0 5.5e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain LBR_tudor PF09465.10 KOO30936.1 - 0.0047 16.7 0.9 0.96 9.3 0.1 2.7 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain Glyco_transf_34 PF05637.12 KOO30936.1 - 0.097 12.4 0.4 0.19 11.4 0.4 1.4 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family Neuralized PF07177.12 KOO30937.1 - 3.6e-10 40.0 0.0 7.9e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Neuralized CLPTM1 PF05602.12 KOO30941.1 - 2.4e-105 353.0 0.1 8.6e-96 321.6 0.1 2.0 1 1 1 2 2 2 2 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 KOO30941.1 - 0.00087 19.0 7.7 0.4 10.5 0.3 3.5 2 1 0 2 2 2 2 PQ loop repeat DUF4293 PF14126.6 KOO30941.1 - 0.081 13.2 2.3 0.19 12.0 2.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) SURF6 PF04935.12 KOO30943.1 - 1.3e-22 80.5 26.3 1.7e-22 80.2 26.3 1.1 1 0 0 1 1 1 1 Surfeit locus protein 6 Peptidase_C2 PF00648.21 KOO30944.1 - 1.2e-86 290.5 0.0 3.2e-50 170.8 0.0 2.2 2 0 0 2 2 2 2 Calpain family cysteine protease Calpain_III PF01067.22 KOO30944.1 - 2.4e-50 170.4 0.0 3.2e-12 46.9 0.0 5.4 5 0 0 5 5 5 5 Calpain large subunit, domain III EF-hand_5 PF13202.6 KOO30944.1 - 0.00049 19.5 3.2 0.76 9.4 0.2 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO30944.1 - 0.01 15.7 1.6 3.7 7.7 0.1 3.2 1 1 1 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO30944.1 - 0.032 13.8 9.3 0.1 12.2 0.2 3.6 2 1 1 3 3 3 0 EF hand EF-hand_7 PF13499.6 KOO30944.1 - 0.15 12.6 5.7 11 6.5 0.3 3.6 3 1 1 4 4 4 0 EF-hand domain pair Dockerin_1 PF00404.18 KOO30944.1 - 0.29 11.3 1.9 19 5.5 2.7 2.5 1 1 1 2 2 2 0 Dockerin type I domain Aa_trans PF01490.18 KOO30945.1 - 3.8e-38 131.3 24.6 4.8e-38 130.9 24.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF4267 PF14087.6 KOO30946.1 - 1.8 8.6 6.2 3.5 7.7 6.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4267) Mlf1IP PF10248.9 KOO30947.1 - 3.5e-09 36.9 0.4 6.5e-09 36.0 0.4 1.5 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein BRO1 PF03097.18 KOO30948.1 - 7.5e-30 104.0 0.5 9.2e-30 103.7 0.5 1.0 1 0 0 1 1 1 1 BRO1-like domain SLS PF14611.6 KOO30948.1 - 0.14 11.9 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator PX PF00787.24 KOO30950.1 - 4.3e-11 42.8 0.0 8.5e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 PX domain Peptidase_C92 PF05708.12 KOO30950.1 - 4.7e-05 23.5 0.0 0.022 14.9 0.0 2.4 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Y_phosphatase3 PF13350.6 KOO30951.1 - 0.013 15.5 1.3 0.013 15.5 1.3 1.9 2 0 0 2 2 2 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 KOO30951.1 - 0.04 13.5 0.1 0.078 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase GalP_UDP_transf PF01087.22 KOO30952.1 - 7.6e-12 46.0 0.0 2.6e-11 44.3 0.0 1.8 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain Fascin PF06268.13 KOO30952.1 - 0.013 15.7 0.0 0.12 12.6 0.0 2.3 2 1 1 3 3 3 0 Fascin domain DUF4931 PF16285.5 KOO30952.1 - 0.015 14.6 0.0 0.091 12.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4931) Tudor-knot PF11717.8 KOO30953.1 - 0.045 13.6 0.0 9 6.3 0.0 2.6 1 1 1 2 2 2 0 RNA binding activity-knot of a chromodomain PABP PF00658.18 KOO30954.1 - 1.3e-12 47.7 0.0 2.7e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain ZZ PF00569.17 KOO30954.1 - 0.025 14.4 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Zinc finger, ZZ type SPRY PF00622.28 KOO30955.1 - 7.9e-12 45.3 0.1 1.1e-11 44.8 0.1 1.3 1 1 0 1 1 1 1 SPRY domain ParD_antitoxin PF03693.14 KOO30957.1 - 0.079 13.4 0.7 0.75 10.3 0.1 2.0 1 1 1 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH PTPS PF01242.19 KOO30959.1 - 1.4e-34 118.7 0.0 1.9e-13 50.4 0.0 3.3 3 0 0 3 3 3 3 6-pyruvoyl tetrahydropterin synthase ADH_zinc_N PF00107.26 KOO30959.1 - 1e-09 38.5 0.0 3.4e-09 36.8 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOO30959.1 - 0.0055 16.2 0.0 0.021 14.3 0.0 1.9 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus 2-Hacid_dh_C PF02826.19 KOO30959.1 - 0.033 13.5 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Thump_like PF18096.1 KOO30959.1 - 0.081 12.9 0.0 17 5.4 0.0 2.8 2 0 0 2 2 2 0 THUMP domain-like ADH_N PF08240.12 KOO30959.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Glyco_hydro_31 PF01055.26 KOO30961.1 - 1e-53 183.1 3.1 1.6e-48 166.0 1.2 2.2 1 1 0 2 2 2 2 Glycosyl hydrolases family 31 DUF5110 PF17137.4 KOO30961.1 - 6.5e-10 39.1 0.0 1.6e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Ricin_B_lectin PF00652.22 KOO30961.1 - 5.7e-09 36.3 1.1 8.3e-09 35.8 0.2 1.8 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Gal_mutarotas_2 PF13802.6 KOO30961.1 - 0.043 14.2 0.5 0.12 12.7 0.5 1.8 1 0 0 1 1 1 0 Galactose mutarotase-like RicinB_lectin_2 PF14200.6 KOO30961.1 - 0.056 14.2 0.2 26 5.6 0.0 2.6 1 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like DUF2403 PF10290.9 KOO30961.1 - 0.11 12.9 0.0 0.31 11.5 0.0 1.7 1 0 0 1 1 1 0 Glycine-rich protein domain (DUF2403) Ank_2 PF12796.7 KOO30962.1 - 8.7e-35 119.2 2.1 4.9e-12 46.3 0.0 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO30962.1 - 6.3e-22 77.7 1.5 5.5e-08 33.2 0.1 4.8 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO30962.1 - 6.5e-15 53.8 0.3 0.026 15.1 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 KOO30962.1 - 2.6e-13 49.8 6.2 0.0064 16.9 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KOO30962.1 - 3.7e-13 49.4 2.6 0.0045 17.3 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ion_trans PF00520.31 KOO30963.1 - 1.3e-21 76.9 8.0 1.9e-21 76.4 8.0 1.2 1 0 0 1 1 1 1 Ion transport protein EF-hand_1 PF00036.32 KOO30963.1 - 3.5e-18 63.7 7.4 5.2e-07 28.8 0.1 3.7 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO30963.1 - 1.5e-17 62.0 7.3 3e-06 26.7 0.1 3.9 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO30963.1 - 3.7e-17 62.5 1.9 3.3e-10 40.3 0.5 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO30963.1 - 7.7e-14 51.3 5.2 8.9e-05 22.3 0.2 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 KOO30963.1 - 3.3e-08 33.4 1.9 0.018 15.0 0.0 3.4 2 1 1 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 KOO30963.1 - 1e-07 31.1 5.6 0.00069 19.0 0.1 3.6 3 0 0 3 3 3 2 EF hand Ion_trans_2 PF07885.16 KOO30963.1 - 2e-05 24.5 2.4 3e-05 23.9 0.3 2.2 2 0 0 2 2 2 1 Ion channel TerB PF05099.13 KOO30963.1 - 0.00047 20.1 0.0 0.19 11.7 0.0 2.6 2 1 0 2 2 2 2 Tellurite resistance protein TerB EF-hand_10 PF14788.6 KOO30963.1 - 0.08 12.8 1.2 1.5 8.8 0.0 2.7 3 0 0 3 3 3 0 EF hand DUF2070 PF09843.9 KOO30963.1 - 0.89 7.8 5.4 1.5 7.0 5.4 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) EF-hand_6 PF13405.6 KOO30964.1 - 0.00016 21.4 0.1 0.0049 16.7 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO30964.1 - 0.00075 18.9 0.2 0.02 14.4 0.0 2.6 2 1 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO30964.1 - 0.0035 16.8 0.9 0.021 14.3 0.0 2.4 2 1 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO30964.1 - 0.023 15.1 0.0 0.21 12.1 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair Phage_integrase PF00589.22 KOO30966.1 - 3.7e-06 26.8 0.0 0.00024 21.0 0.0 2.4 3 0 0 3 3 3 2 Phage integrase family WD40 PF00400.32 KOO30968.1 - 1.1e-74 244.4 40.3 2.8e-09 37.5 0.2 10.3 10 0 0 10 10 10 9 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO30968.1 - 1.2e-25 90.2 11.6 0.0085 15.1 0.0 8.2 1 1 6 8 8 8 8 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO30968.1 - 5.5e-22 77.9 8.9 0.0048 17.2 0.0 9.7 2 2 7 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO30968.1 - 5.8e-21 73.9 4.6 0.48 10.4 0.0 8.6 8 0 0 8 8 8 8 WD40-like Beta Propeller Repeat eIF2A PF08662.11 KOO30968.1 - 5e-13 49.4 2.6 0.0016 18.3 0.0 4.4 1 1 3 5 5 5 5 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 KOO30968.1 - 2.4e-08 32.8 0.0 0.57 8.4 0.0 5.4 1 1 6 7 7 7 4 WD repeat-containing and planar cell polarity effector protein Fritz APAF1_C PF17908.1 KOO30968.1 - 1.6e-05 24.9 0.0 7.8e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 APAF-1 helical domain Utp8 PF10395.9 KOO30968.1 - 0.0011 17.6 0.9 2 6.8 0.1 3.7 3 1 1 5 5 5 1 Utp8 family dsrm PF00035.26 KOO30968.1 - 0.0017 19.1 1.3 4.6 8.0 0.0 5.5 6 0 0 6 6 6 1 Double-stranded RNA binding motif IKI3 PF04762.12 KOO30968.1 - 0.0017 16.5 3.6 20 3.0 0.0 4.1 1 1 1 3 3 3 0 IKI3 family Emaravirus_P4 PF16505.5 KOO30968.1 - 0.012 14.7 0.0 6 5.8 0.0 3.3 2 2 2 5 5 5 0 P4 movement protein of Emaravirus, and the 30K superfamily Glyco_transf_15 PF01793.16 KOO30970.1 - 4.7e-09 36.0 0.0 1.1e-08 34.7 0.0 1.7 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Myb_DNA-binding PF00249.31 KOO30972.1 - 1.4e-23 82.8 0.1 5.5e-11 42.5 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO30972.1 - 3.4e-18 65.7 0.0 9.8e-14 51.4 0.0 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Sigma70_r4_2 PF08281.12 KOO30972.1 - 0.036 13.7 0.0 0.081 12.6 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 Myb_DNA-bind_2 PF08914.11 KOO30972.1 - 0.16 12.2 0.1 6.8 7.0 0.1 3.0 3 1 0 3 3 3 0 Rap1 Myb domain Chloroa_b-bind PF00504.21 KOO30973.1 - 3.7e-13 50.3 0.2 4.3e-13 50.1 0.2 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DUF4079 PF13301.6 KOO30974.1 - 6.7e-45 152.7 0.3 1.2e-44 151.8 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4079) MerR-DNA-bind PF09278.11 KOO30974.1 - 0.0081 16.7 0.2 0.016 15.7 0.2 1.5 1 0 0 1 1 1 1 MerR, DNA binding Fez1 PF06818.15 KOO30974.1 - 0.027 14.9 0.2 0.04 14.4 0.2 1.2 1 0 0 1 1 1 0 Fez1 Phage_GP20 PF06810.11 KOO30974.1 - 0.044 13.6 0.0 0.063 13.1 0.0 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 Dynamitin PF04912.14 KOO30974.1 - 0.064 12.6 0.2 0.093 12.0 0.2 1.1 1 0 0 1 1 1 0 Dynamitin DivIC PF04977.15 KOO30974.1 - 0.093 12.5 0.9 4.4 7.1 0.0 2.7 3 0 0 3 3 3 0 Septum formation initiator Seryl_tRNA_N PF02403.22 KOO30974.1 - 0.4 10.9 1.1 0.89 9.8 1.1 1.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DHC_N2 PF08393.13 KOO30978.1 - 1.5e-46 159.3 0.1 1.5e-46 159.3 0.1 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 Suf PF05843.14 KOO30979.1 - 1.6e-30 107.1 0.0 7.9e-13 49.0 0.0 3.9 4 0 0 4 4 4 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 KOO30979.1 - 5.4e-06 26.8 3.2 0.0072 16.8 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30979.1 - 0.00056 20.5 32.5 0.019 15.8 1.2 9.2 4 3 6 10 10 10 3 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KOO30979.1 - 0.056 13.4 1.8 22 5.1 0.2 3.4 2 1 1 3 3 3 0 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 KOO30979.1 - 0.11 12.7 0.7 17 5.8 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat STIMATE PF12400.8 KOO30980.1 - 3.3e-27 95.5 3.7 5.4e-27 94.8 3.7 1.3 1 0 0 1 1 1 1 STIMATE family Nucleotid_trans PF03407.16 KOO30981.1 - 8.5e-31 107.6 0.0 1.1e-30 107.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Vir_act_alpha_C PF10400.9 KOO30981.1 - 0.14 12.9 0.0 0.31 11.7 0.0 1.5 1 0 0 1 1 1 0 Virulence activator alpha C-term ClpS PF02617.17 KOO30982.1 - 1.2e-12 47.4 0.2 1.9e-12 46.8 0.2 1.2 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS DUF900 PF05990.12 KOO30982.1 - 3.2e-05 23.5 0.1 4.2e-05 23.2 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 KOO30982.1 - 0.026 13.8 0.0 0.034 13.4 0.0 1.1 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Imm44 PF15571.6 KOO30982.1 - 0.06 13.6 0.0 0.091 13.0 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 44 Abhydrolase_1 PF00561.20 KOO30982.1 - 0.18 11.4 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold Oxidored_FMN PF00724.20 KOO30985.1 - 2e-71 241.1 0.0 1.4e-70 238.3 0.0 1.9 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Pyr_redox_2 PF07992.14 KOO30985.1 - 2.5e-26 92.6 5.1 4.3e-15 55.7 0.1 3.2 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO30985.1 - 2.3e-07 30.4 2.8 0.0006 19.2 0.0 3.2 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOO30985.1 - 4.3e-07 30.1 9.3 3.2e-05 24.1 0.1 3.3 2 1 1 3 3 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KOO30985.1 - 2.4e-06 28.0 6.6 0.29 11.7 0.3 4.8 4 1 0 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO30985.1 - 0.00057 19.6 12.6 0.099 12.2 1.3 4.6 3 1 1 4 4 4 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 KOO30985.1 - 0.00069 19.0 0.0 0.0014 18.0 0.0 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 KOO30985.1 - 0.0018 17.5 7.6 0.13 11.3 1.4 3.2 3 0 0 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 KOO30985.1 - 0.0026 17.2 6.4 0.056 12.8 0.1 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 KOO30985.1 - 0.017 14.4 2.3 0.56 9.4 0.6 3.2 2 1 0 2 2 2 0 Thi4 family K_oxygenase PF13434.6 KOO30985.1 - 0.02 14.1 0.0 3.3 6.8 0.0 2.4 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 KOO30985.1 - 0.023 13.4 14.8 0.1 11.2 0.0 3.7 4 1 1 5 5 5 0 HI0933-like protein FAD_binding_3 PF01494.19 KOO30985.1 - 0.1 11.8 2.6 1.1 8.4 0.2 2.5 3 0 0 3 3 3 0 FAD binding domain NAD_binding_9 PF13454.6 KOO30985.1 - 0.2 11.6 4.7 0.46 10.5 0.1 3.4 4 0 0 4 4 4 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 KOO30985.1 - 0.65 9.0 5.9 0.13 11.3 0.8 2.3 2 1 0 2 2 2 0 Lycopene cyclase protein CoA_binding PF02629.19 KOO30985.1 - 0.92 10.2 3.4 36 5.1 0.1 3.8 4 0 0 4 4 4 0 CoA binding domain GIDA PF01134.22 KOO30985.1 - 2.7 7.0 5.8 34 3.3 5.8 2.3 1 1 0 1 1 1 0 Glucose inhibited division protein A ATPgrasp_ST PF14397.6 KOO30986.1 - 5.9e-05 22.4 0.0 0.00039 19.7 0.0 1.9 1 1 1 2 2 2 1 Sugar-transfer associated ATP-grasp TPR_7 PF13176.6 KOO30988.1 - 0.00037 20.3 5.9 1.6 8.9 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO30988.1 - 0.0021 18.7 0.1 0.81 10.7 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat mRNA_stabil PF13929.6 KOO30988.1 - 0.0033 16.5 0.7 0.0059 15.6 0.7 1.4 1 0 0 1 1 1 1 mRNA stabilisation TPR_6 PF13174.6 KOO30988.1 - 0.054 14.2 0.5 6.2 7.7 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO30988.1 - 0.26 11.6 7.4 10 6.6 0.0 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF1910 PF08928.10 KOO30988.1 - 0.29 11.1 4.6 1.4 8.9 4.4 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1910) Methyltransf_21 PF05050.12 KOO30989.1 - 1.3e-08 35.0 0.0 2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain DUF3011 PF11218.8 KOO30989.1 - 0.0057 16.7 3.4 0.013 15.5 3.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3011) BRCT_3 PF18428.1 KOO30989.1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.6 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain BLM10_mid PF16507.5 KOO30990.1 - 8.1e-55 186.4 0.0 8.6e-30 103.9 0.0 2.2 2 0 0 2 2 2 2 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 KOO30990.1 - 5.1e-29 100.0 3.4 3e-28 97.6 0.0 3.9 3 1 1 4 4 4 1 Domain of unknown function (DUF3437) HEAT PF02985.22 KOO30990.1 - 0.093 13.0 4.6 2.4 8.6 0.0 4.8 3 0 0 3 3 3 0 HEAT repeat Calc_CGRP_IAPP PF00214.19 KOO30995.1 - 0.071 13.5 0.1 0.071 13.5 0.1 1.2 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family PDZ_6 PF17820.1 KOO30996.1 - 4.6e-18 64.8 0.0 3.3e-09 36.4 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KOO30996.1 - 3.1e-16 59.5 0.0 3e-07 30.7 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 KOO30996.1 - 1.4e-15 57.4 0.0 1.2e-06 28.8 0.0 2.4 2 0 0 2 2 2 2 PDZ domain Lig_chan PF00060.26 KOO30996.1 - 2.9e-07 30.4 0.1 5.5e-07 29.5 0.1 1.5 1 0 0 1 1 1 1 Ligand-gated ion channel Tricorn_PDZ PF14685.6 KOO30996.1 - 2.9e-06 27.1 0.0 0.02 14.8 0.0 2.4 2 0 0 2 2 2 2 Tricorn protease PDZ domain GRASP55_65 PF04495.14 KOO30996.1 - 0.00015 22.1 0.0 1.4 9.2 0.0 2.9 3 0 0 3 3 3 2 GRASP55/65 PDZ-like domain Aldo_ket_red PF00248.21 KOO30997.1 - 9.4e-19 67.7 0.0 1.5e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_16 PF10294.9 KOO30998.1 - 3.6e-27 95.2 0.0 4.9e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 KOO30998.1 - 0.00015 21.3 0.0 0.00019 21.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KOO30998.1 - 0.00035 20.2 0.0 0.00056 19.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 KOO30998.1 - 0.0015 19.2 0.0 0.0028 18.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO30998.1 - 0.019 15.7 0.0 0.037 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 KOO30998.1 - 0.066 13.0 0.0 0.081 12.7 0.0 1.1 1 0 0 1 1 1 0 Met-10+ like-protein DUF4586 PF15239.6 KOO30999.1 - 6.6e-07 29.8 0.0 1.4e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) Dpy-30 PF05186.13 KOO31000.1 - 1.8e-18 65.9 0.1 4e-18 64.8 0.1 1.6 1 0 0 1 1 1 1 Dpy-30 motif Epimerase PF01370.21 KOO31000.1 - 5.5e-05 22.7 0.0 0.011 15.2 0.0 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADK PF00406.22 KOO31000.1 - 0.00011 22.3 0.0 0.0003 20.9 0.0 1.6 2 0 0 2 2 2 1 Adenylate kinase AAA_17 PF13207.6 KOO31000.1 - 0.0015 18.9 0.9 0.0046 17.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain PknG_rubred PF16919.5 KOO31000.1 - 0.012 15.8 0.9 1.7 8.8 0.2 3.0 3 0 0 3 3 3 0 Protein kinase G rubredoxin domain PsbP PF01789.16 KOO31001.1 - 0.00057 20.1 0.0 0.00075 19.7 0.0 1.1 1 0 0 1 1 1 1 PsbP Beach PF02138.18 KOO31002.1 - 1.1e-93 313.6 0.0 1.2e-93 313.4 0.0 1.0 1 0 0 1 1 1 1 Beige/BEACH domain EF-hand_1 PF00036.32 KOO31004.1 - 7.5e-10 37.7 0.0 0.0021 17.5 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO31004.1 - 9.5e-08 32.4 0.1 1.7e-05 25.2 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO31004.1 - 2.1e-06 27.5 0.3 0.06 13.2 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO31004.1 - 4.1e-06 26.3 0.0 0.12 12.4 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO31004.1 - 2.8e-05 23.4 0.0 0.28 10.8 0.0 3.0 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 KOO31004.1 - 0.00034 20.9 0.8 0.0069 16.7 0.0 2.8 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Lipase_chap PF03280.14 KOO31004.1 - 0.029 14.4 2.5 0.068 13.1 2.5 1.6 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein Hemerythrin PF01814.23 KOO31004.1 - 0.039 14.6 0.8 0.099 13.3 0.6 1.8 1 1 0 1 1 1 0 Hemerythrin HHE cation binding domain Drc1-Sld2 PF11719.8 KOO31004.1 - 0.11 12.0 2.5 0.25 10.9 0.4 2.0 2 0 0 2 2 2 0 DNA replication and checkpoint protein SLATT_fungal PF18142.1 KOO31004.1 - 0.16 12.0 0.6 5.5 7.0 0.0 2.3 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain Ketoacyl-synt_C PF02801.22 KOO31005.1 - 2.3e-30 105.1 1.7 6.3e-30 103.6 1.7 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 KOO31005.1 - 9.4e-26 90.9 7.7 2.4e-25 89.6 7.7 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thioesterase PF00975.20 KOO31005.1 - 1.4e-06 28.6 0.1 2.4e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 KOO31005.1 - 0.00049 20.8 4.8 0.00049 20.8 4.8 2.3 1 1 1 2 2 2 1 Alpha/beta hydrolase family PX PF00787.24 KOO31007.1 - 5.5e-23 81.1 0.0 9.1e-23 80.4 0.0 1.4 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 KOO31007.1 - 3e-05 23.7 4.7 0.00069 19.2 4.5 2.4 1 1 0 1 1 1 1 Vps5 C terminal like Haem_bd PF14376.6 KOO31008.1 - 0.087 12.8 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Haem-binding domain Nuc_sug_transp PF04142.15 KOO31009.1 - 6.6e-13 48.5 4.8 9e-13 48.1 4.8 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EF-hand_1 PF00036.32 KOO31010.1 - 1.7e-16 58.4 0.2 6.4e-08 31.6 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO31010.1 - 2.3e-14 52.1 0.2 2.8e-06 26.6 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31010.1 - 9.5e-14 50.1 0.1 1.7e-05 24.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO31010.1 - 4.1e-12 46.4 0.0 7.8e-12 45.5 0.0 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO31010.1 - 4.1e-12 45.7 0.4 3.5e-10 39.6 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO31010.1 - 4.8e-05 23.6 0.0 7.5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO31010.1 - 0.00023 21.0 0.1 0.0032 17.4 0.1 2.0 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Tudor_1_RapA PF18339.1 KOO31011.1 - 9e-08 31.9 0.4 25 4.9 0.0 7.6 9 0 0 9 9 9 4 RapA N-terminal Tudor like domain 1 HycI PF01750.18 KOO31011.1 - 0.34 10.7 7.1 32 4.3 0.0 5.3 5 2 2 7 7 7 0 Hydrogenase maturation protease LpxC PF03331.13 KOO31013.1 - 8.5e-62 209.1 0.0 1.7e-61 208.1 0.0 1.4 1 1 0 1 1 1 1 UDP-3-O-acyl N-acetylglycosamine deacetylase CS PF04969.16 KOO31014.1 - 1.6e-08 35.4 0.0 2.4e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 CS domain Siah-Interact_N PF09032.11 KOO31014.1 - 0.00022 21.5 0.0 0.00041 20.6 0.0 1.4 1 0 0 1 1 1 1 Siah interacting protein, N terminal SGS PF05002.15 KOO31014.1 - 0.0034 17.5 0.2 0.0061 16.6 0.2 1.4 1 0 0 1 1 1 1 SGS domain FTHFS PF01268.19 KOO31014.1 - 0.071 11.3 0.0 0.094 10.9 0.0 1.1 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase Abhydrolase_3 PF07859.13 KOO31015.1 - 3.1e-15 56.6 0.2 7.2e-15 55.4 0.2 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold LRR_8 PF13855.6 KOO31015.1 - 2.2e-09 37.0 0.7 7.8e-09 35.2 0.1 2.2 3 0 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 KOO31015.1 - 7.7e-08 32.5 0.1 0.00064 20.1 0.1 2.8 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) Say1_Mug180 PF10340.9 KOO31015.1 - 3.2e-06 26.2 0.0 4.9e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase LRR_9 PF14580.6 KOO31015.1 - 0.0036 16.8 0.0 0.016 14.7 0.0 1.8 1 1 0 2 2 2 1 Leucine-rich repeat DUF3089 PF11288.8 KOO31015.1 - 0.064 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Lactamase_B_2 PF12706.7 KOO31015.1 - 0.094 12.2 2.3 0.092 12.3 0.4 1.9 2 0 0 2 2 2 0 Beta-lactamase superfamily domain DUF1843 PF08898.10 KOO31015.1 - 0.35 11.4 3.6 0.29 11.7 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) PaO PF08417.12 KOO31019.1 - 5.7e-13 48.8 0.0 1e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 Pheophorbide a oxygenase ABM PF03992.16 KOO31020.1 - 1.3e-18 66.8 0.1 1.6e-18 66.6 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Mob1_phocein PF03637.17 KOO31022.1 - 4.9e-65 218.7 0.1 6.7e-65 218.2 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family Mpv17_PMP22 PF04117.12 KOO31022.1 - 2.2e-15 56.6 0.5 4.6e-15 55.6 0.5 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family DUF3754 PF12576.8 KOO31023.1 - 6.8e-09 35.8 0.0 1.1e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) DAO PF01266.24 KOO31024.1 - 1e-10 41.8 0.0 1.4e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase CPBP PF02517.16 KOO31026.1 - 1.4e-14 54.2 5.3 1.4e-14 54.2 5.3 1.7 1 1 0 2 2 2 1 CPBP intramembrane metalloprotease DUF2723 PF11028.8 KOO31026.1 - 0.11 12.4 8.0 0.046 13.7 3.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2723) EF-hand_1 PF00036.32 KOO31027.1 - 1.7e-21 74.1 6.6 6e-06 25.4 0.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO31027.1 - 2e-15 55.3 3.0 0.0053 16.6 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO31027.1 - 4e-15 55.4 8.5 1.1e-05 25.2 1.0 3.6 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 KOO31027.1 - 8.8e-13 48.5 6.6 0.00028 21.3 0.2 3.3 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO31027.1 - 5e-10 38.4 3.4 0.033 13.7 0.0 3.7 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 KOO31027.1 - 2.4e-06 27.4 0.6 0.017 15.0 0.0 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO31027.1 - 0.0067 16.7 0.2 0.6 10.5 0.0 2.9 2 1 1 3 3 3 1 EF-hand domain Galactosyl_T PF01762.21 KOO31028.1 - 0.0042 16.9 0.0 0.013 15.4 0.0 1.8 1 1 0 1 1 1 1 Galactosyltransferase Transferase PF02458.15 KOO31028.1 - 0.023 13.3 0.0 0.034 12.8 0.0 1.1 1 0 0 1 1 1 0 Transferase family WGG PF10273.9 KOO31029.1 - 1.3e-15 57.8 0.1 2.3e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 TBCC PF07986.12 KOO31030.1 - 4e-32 110.5 0.0 6e-32 109.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 KOO31030.1 - 4.1e-05 24.0 0.9 6.1e-05 23.4 0.9 1.2 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain HOIP-UBA PF16678.5 KOO31030.1 - 0.091 12.8 0.3 0.18 11.8 0.3 1.5 1 0 0 1 1 1 0 HOIP UBA domain pair Glyco_hydro_67M PF07488.12 KOO31030.1 - 0.093 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 middle domain Dynein_light PF01221.18 KOO31032.1 - 7.9e-21 74.2 1.9 1e-20 73.8 1.9 1.2 1 0 0 1 1 1 1 Dynein light chain type 1 Glyco_transf_8 PF01501.20 KOO31033.1 - 0.00012 21.7 0.2 0.0047 16.5 0.2 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 8 PP_kinase_C PF13090.6 KOO31033.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain 2 Glyco_hydro_3 PF00933.21 KOO31034.1 - 1.9e-40 139.2 0.0 2.4e-40 138.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOO31034.1 - 9.2e-20 70.5 0.0 1.6e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain CBM_25 PF03423.13 KOO31034.1 - 0.017 15.3 1.8 0.057 13.7 0.2 2.5 3 0 0 3 3 3 0 Carbohydrate binding domain (family 25) HTH_40 PF14493.6 KOO31035.1 - 0.00048 20.5 0.0 0.00062 20.2 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain Mitoc_L55 PF09776.9 KOO31036.1 - 0.032 14.0 0.1 1.3 8.7 0.0 3.0 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L55 Gly-zipper_Omp PF13488.6 KOO31037.1 - 0.016 15.2 0.4 0.016 15.2 0.4 3.2 3 0 0 3 3 3 0 Glycine zipper Phage_holin_3_1 PF05106.12 KOO31037.1 - 0.029 14.8 2.9 0.056 13.9 0.2 2.3 1 1 1 2 2 2 0 Phage holin family (Lysis protein S) 7TM-7TMR_HD PF07698.11 KOO31037.1 - 0.062 13.1 0.6 0.08 12.7 0.6 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DAHP_snth_FXD PF18152.1 KOO31037.1 - 0.19 11.6 0.4 0.72 9.7 0.1 1.9 2 0 0 2 2 2 0 DAHP synthase ferredoxin-like domain FUN14 PF04930.15 KOO31037.1 - 1.2 9.6 7.9 2.6 8.5 7.9 1.6 1 1 0 1 1 1 0 FUN14 family LRR_5 PF13306.6 KOO31038.1 - 3.7e-51 172.4 0.0 6.8e-28 97.2 0.0 2.0 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO31038.1 - 4.3e-10 39.2 0.0 0.0072 16.1 0.0 5.0 2 2 3 5 5 5 4 Leucine rich repeat He_PIG PF05345.12 KOO31038.1 - 0.0042 17.2 9.5 77 3.6 0.9 6.3 6 1 1 7 7 7 0 Putative Ig domain Transp_Tc5_C PF04236.15 KOO31038.1 - 1.6 9.1 5.7 24 5.4 0.1 3.9 4 1 1 5 5 5 0 Tc5 transposase C-terminal domain TetR_C_11 PF16859.5 KOO31040.1 - 0.036 14.4 1.1 0.036 14.4 1.1 3.5 3 1 1 4 4 4 0 Tetracyclin repressor-like, C-terminal domain APG6_N PF17675.1 KOO31040.1 - 0.32 11.5 2.5 0.55 10.7 2.5 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Circo_capsid PF02443.15 KOO31042.1 - 0.24 11.0 3.2 0.29 10.7 3.2 1.1 1 0 0 1 1 1 0 Circovirus capsid protein PRIMA1 PF16101.5 KOO31043.1 - 0.0031 17.5 0.9 0.0092 16.0 0.6 1.9 1 1 1 2 2 2 1 Proline-rich membrane anchor 1 RIFIN PF02009.16 KOO31043.1 - 0.25 11.2 4.9 20 4.9 0.0 2.3 2 0 0 2 2 2 0 Rifin Tmemb_170 PF10190.9 KOO31043.1 - 0.57 10.6 0.1 0.57 10.6 0.1 2.4 2 0 0 2 2 2 0 Putative transmembrane protein 170 DUF2613 PF11021.8 KOO31043.1 - 0.7 10.1 0.1 0.7 10.1 0.1 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF2613) Amnionless PF14828.6 KOO31043.1 - 1.1 8.0 2.9 12 4.6 0.0 2.1 2 0 0 2 2 2 0 Amnionless FtsJ PF01728.19 KOO31044.1 - 0.0011 19.2 0.1 0.0014 18.8 0.1 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 KOO31044.1 - 0.0074 16.1 0.0 0.0095 15.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 KOO31044.1 - 0.014 15.1 0.0 0.019 14.7 0.0 1.4 1 1 0 1 1 1 0 Met-10+ like-protein Methyltransf_25 PF13649.6 KOO31044.1 - 0.025 15.3 0.1 0.043 14.5 0.1 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KOO31044.1 - 0.026 14.3 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UPF0146 PF03686.13 KOO31044.1 - 0.039 13.8 0.0 0.051 13.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Methyltransf_11 PF08241.12 KOO31044.1 - 0.078 13.6 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain OMPdecase PF00215.24 KOO31045.1 - 5.4e-23 81.8 0.2 7.1e-23 81.4 0.2 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family SEP PF08059.13 KOO31046.1 - 0.069 13.7 0.0 0.46 11.1 0.0 2.3 2 0 0 2 2 2 0 SEP domain SlyX PF04102.12 KOO31046.1 - 2.7 8.7 7.5 1.8 9.3 0.7 2.8 3 0 0 3 3 3 0 SlyX MORN PF02493.20 KOO31049.1 - 8.6e-21 72.5 35.6 6.3e-05 22.6 0.3 9.8 11 0 0 11 11 11 6 MORN repeat DUF2576 PF10845.8 KOO31049.1 - 0.086 12.5 0.1 0.24 11.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) FHA PF00498.26 KOO31049.1 - 0.094 13.1 0.1 22 5.5 0.0 2.4 2 0 0 2 2 2 0 FHA domain TPR_16 PF13432.6 KOO31050.1 - 5.3e-05 23.8 8.6 5.3e-05 23.8 8.6 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO31050.1 - 7e-05 22.6 0.2 0.19 11.9 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO31050.1 - 0.0083 15.9 0.0 2.5 8.1 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat AlkA_N PF06029.11 KOO31050.1 - 0.064 13.5 0.7 9.3 6.6 0.3 2.3 2 0 0 2 2 2 0 AlkA N-terminal domain DUF4856 PF16148.5 KOO31050.1 - 0.11 11.5 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4856) TPR_19 PF14559.6 KOO31050.1 - 0.71 10.4 11.4 0.13 12.8 4.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO31050.1 - 4.7 7.4 12.7 0.23 11.6 4.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat ABC_tran PF00005.27 KOO31051.1 - 6.6e-52 175.7 0.7 1.4e-28 100.1 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 KOO31051.1 - 8.7e-18 64.1 10.4 5e-13 48.9 1.0 3.4 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 KOO31051.1 - 1.3e-13 51.5 8.0 0.0085 15.9 0.1 4.4 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO31051.1 - 5.4e-10 39.1 0.9 0.00034 20.1 0.1 4.3 3 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO31051.1 - 6.6e-10 39.6 0.3 3.8e-05 24.2 0.3 2.5 2 0 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 KOO31051.1 - 7.6e-08 32.6 0.1 0.00024 21.2 0.0 3.1 2 1 1 3 3 3 1 Dynamin family AAA_23 PF13476.6 KOO31051.1 - 2.1e-07 31.6 6.0 0.0061 17.1 0.0 4.5 5 0 0 5 5 4 2 AAA domain AAA_29 PF13555.6 KOO31051.1 - 7.3e-07 28.8 0.1 0.0059 16.3 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 KOO31051.1 - 1.7e-06 27.9 0.9 0.0081 15.9 0.2 3.1 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KOO31051.1 - 8.6e-06 26.3 0.4 0.17 12.4 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.6 KOO31051.1 - 1.8e-05 25.0 0.2 0.13 12.6 0.1 3.2 3 1 0 3 3 3 2 AAA domain AAA_28 PF13521.6 KOO31051.1 - 4.2e-05 23.8 0.1 0.45 10.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 KOO31051.1 - 6.1e-05 23.2 0.0 0.55 10.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 KOO31051.1 - 6.6e-05 22.9 0.0 0.14 12.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KOO31051.1 - 7.9e-05 22.7 0.0 0.046 13.8 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_24 PF13479.6 KOO31051.1 - 0.00024 20.9 0.0 1.1 8.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain ATG16 PF08614.11 KOO31051.1 - 0.00049 20.4 1.9 0.00049 20.4 1.9 2.5 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) cobW PF02492.19 KOO31051.1 - 0.0005 19.7 0.1 2.4 7.7 0.0 3.5 4 0 0 4 4 3 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 KOO31051.1 - 0.00055 19.9 0.0 0.63 9.9 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 KOO31051.1 - 0.00056 20.3 0.0 0.68 10.4 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 KOO31051.1 - 0.00086 19.5 1.4 1.1 9.4 0.0 3.7 5 0 0 5 5 3 1 Helicase HerA, central domain TsaE PF02367.17 KOO31051.1 - 0.0015 18.5 0.1 0.44 10.6 0.0 2.7 3 0 0 3 3 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran_CTD PF16326.5 KOO31051.1 - 0.0019 18.4 3.8 0.0019 18.4 3.8 2.6 3 0 0 3 3 1 1 ABC transporter C-terminal domain AAA_15 PF13175.6 KOO31051.1 - 0.0022 17.8 0.9 3.3 7.3 0.0 3.7 3 1 1 4 4 4 1 AAA ATPase domain AAA_14 PF13173.6 KOO31051.1 - 0.0024 17.9 0.3 1.6 8.7 0.0 3.3 3 1 0 3 3 2 1 AAA domain MeaB PF03308.16 KOO31051.1 - 0.0027 16.7 1.1 0.21 10.5 0.1 2.7 3 0 0 3 3 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 KOO31051.1 - 0.0035 17.0 0.4 0.6 9.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_13 PF13166.6 KOO31051.1 - 0.004 15.9 8.0 1.5 7.4 0.0 4.3 4 1 1 5 5 5 1 AAA domain Thymidylate_kin PF02223.17 KOO31051.1 - 0.0066 16.1 2.0 0.21 11.3 0.0 2.9 3 0 0 3 3 2 1 Thymidylate kinase Roc PF08477.13 KOO31051.1 - 0.008 16.4 0.0 1.5 9.0 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 KOO31051.1 - 0.017 14.8 0.0 0.46 10.1 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 KOO31051.1 - 0.018 14.7 0.1 5.4 6.5 0.0 4.0 4 1 1 5 5 5 0 AAA domain Zeta_toxin PF06414.12 KOO31051.1 - 0.027 13.8 2.3 1.7 7.9 0.0 3.1 3 1 0 3 3 3 0 Zeta toxin AAA_17 PF13207.6 KOO31051.1 - 0.032 14.7 3.3 1.2 9.6 0.0 3.5 3 1 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 KOO31051.1 - 0.037 13.8 0.0 3 7.5 0.0 2.7 3 0 0 3 3 2 0 IstB-like ATP binding protein NTPase_1 PF03266.15 KOO31051.1 - 0.038 13.9 0.0 15 5.5 0.0 3.0 2 0 0 2 2 2 0 NTPase RuvB_N PF05496.12 KOO31051.1 - 0.044 13.5 0.0 9.9 5.9 0.0 3.0 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 KOO31051.1 - 0.048 14.0 0.1 16 6.0 0.0 3.0 3 0 0 3 3 2 0 RNA helicase ATP-synt_ab PF00006.25 KOO31051.1 - 0.05 13.3 0.0 5.6 6.6 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF5082 PF16888.5 KOO31051.1 - 0.051 13.9 4.0 0.19 12.0 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) ATPase_2 PF01637.18 KOO31051.1 - 0.051 13.5 0.4 6.2 6.7 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 KOO31051.1 - 0.051 12.7 0.1 2.2 7.4 0.0 2.7 2 1 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 KOO31051.1 - 0.071 12.6 0.0 14 5.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF503 PF04456.12 KOO31051.1 - 0.08 12.8 0.1 17 5.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF503) Rad17 PF03215.15 KOO31051.1 - 0.095 12.6 0.0 6.6 6.6 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain GTP_EFTU PF00009.27 KOO31051.1 - 0.13 11.8 0.0 2.4 7.6 0.0 2.9 4 0 0 4 4 3 0 Elongation factor Tu GTP binding domain DUF4615 PF15393.6 KOO31051.1 - 0.26 11.8 2.0 4.5 7.8 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) BEX PF04538.12 KOO31051.1 - 0.41 11.3 0.1 0.41 11.3 0.1 3.1 3 0 0 3 3 2 0 Brain expressed X-linked like family APG6_N PF17675.1 KOO31051.1 - 0.89 10.1 8.8 6.7 7.2 1.4 2.8 2 0 0 2 2 2 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 KOO31051.1 - 1.5 9.8 5.4 2.1 9.3 0.2 2.9 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF3584 PF12128.8 KOO31051.1 - 2.6 5.5 17.8 0.23 8.9 0.4 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3584) Metal_resist PF13801.6 KOO31051.1 - 4.1 7.6 16.3 3.5 7.8 0.2 3.3 3 1 0 3 3 3 0 Heavy-metal resistance Ank_2 PF12796.7 KOO31054.1 - 3.9e-22 78.6 1.7 1e-12 48.4 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 KOO31054.1 - 3.7e-17 61.9 0.9 0.00015 22.0 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 KOO31054.1 - 9.2e-17 61.2 0.3 7.4e-05 23.2 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO31054.1 - 1.1e-12 46.9 0.2 0.12 13.0 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KOO31054.1 - 3.8e-12 46.2 0.1 4.1e-08 33.3 0.0 4.2 4 1 1 5 5 5 1 Ankyrin repeats (many copies) DUF1843 PF08898.10 KOO31054.1 - 0.24 11.9 6.8 0.6 10.6 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) Ank_2 PF12796.7 KOO31055.1 - 1.9e-58 195.0 19.1 3.2e-13 50.1 0.3 8.1 5 1 3 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO31055.1 - 4.5e-42 141.9 9.3 8.8e-09 35.7 0.0 9.2 6 3 3 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 KOO31055.1 - 2.4e-34 116.3 20.3 0.0036 17.7 0.0 12.3 12 0 0 12 12 12 9 Ankyrin repeat Ank_3 PF13606.6 KOO31055.1 - 7.1e-33 109.0 16.2 0.012 16.1 0.0 12.9 12 0 0 12 12 12 8 Ankyrin repeat Ank_5 PF13857.6 KOO31055.1 - 9.7e-33 111.8 21.1 2e-06 28.0 0.0 11.4 6 3 6 12 12 12 10 Ankyrin repeats (many copies) ADPrib_exo_Tox PF03496.14 KOO31055.1 - 0.00089 18.6 0.0 0.002 17.5 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Thioredoxin PF00085.20 KOO31055.1 - 0.0092 16.0 0.0 0.045 13.7 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.6 KOO31055.1 - 0.048 13.9 0.1 0.18 12.0 0.1 2.0 1 0 0 1 1 1 0 Thioredoxin-like DUF3881 PF12997.7 KOO31055.1 - 0.28 10.4 0.7 2.8 7.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) Peptidase_M3 PF01432.20 KOO31056.1 - 6.6e-61 207.0 1.1 9.8e-41 140.5 0.1 3.2 1 1 2 3 3 3 3 Peptidase family M3 DUF5375 PF17345.2 KOO31056.1 - 0.064 13.1 0.7 0.23 11.3 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5375) LIP1 PF15904.5 KOO31056.1 - 0.072 13.4 0.0 4.4 7.7 0.0 2.5 2 0 0 2 2 2 0 LKB1 serine/threonine kinase interacting protein 1 GCIP PF13324.6 KOO31056.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting AhpC-TSA PF00578.21 KOO31057.1 - 2.2e-08 34.1 0.0 5.5e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 AhpC/TSA family Med9 PF07544.13 KOO31057.1 - 0.15 12.2 1.6 0.37 10.9 0.2 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Glyco_transf_49 PF13896.6 KOO31058.1 - 1.3e-28 100.3 0.0 9.5e-26 90.9 0.0 2.2 2 0 0 2 2 2 2 Glycosyl-transferase for dystroglycan pPIWI_RE_REase PF18154.1 KOO31058.1 - 0.11 12.5 0.0 0.46 10.5 0.0 2.0 2 0 0 2 2 2 0 REase associating with pPIWI_RE TetR_C_25 PF17933.1 KOO31058.1 - 0.17 12.2 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain RCC1 PF00415.18 KOO31059.1 - 1.5e-58 195.2 20.0 4.9e-10 39.9 0.5 7.7 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 KOO31059.1 - 8.3e-18 64.6 0.0 3.3e-07 30.5 0.0 3.1 2 2 1 3 3 3 2 BTB/POZ domain RCC1_2 PF13540.6 KOO31059.1 - 2.3e-15 55.9 51.3 1.5e-05 24.6 3.9 8.0 9 0 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat EF-hand_1 PF00036.32 KOO31060.1 - 7.9e-16 56.3 0.1 0.01 15.3 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO31060.1 - 2.4e-14 52.0 0.3 0.015 15.2 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO31060.1 - 6.7e-14 50.7 0.5 0.015 14.8 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO31060.1 - 4.7e-12 46.2 0.0 0.00069 20.0 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO31060.1 - 4.3e-07 29.7 0.0 1.1 9.2 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain pair Indigoidine_A PF04227.12 KOO31060.1 - 0.059 12.7 0.1 0.088 12.2 0.1 1.2 1 0 0 1 1 1 0 Indigoidine synthase A like protein SPARC_Ca_bdg PF10591.9 KOO31060.1 - 0.09 13.1 0.0 0.6 10.5 0.0 2.3 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region HMMR_C PF15908.5 KOO31061.1 - 1.1e-08 35.5 7.5 1.1e-08 35.5 7.5 2.7 2 2 1 3 3 3 1 Hyaluronan mediated motility receptor C-terminal HALZ PF02183.18 KOO31061.1 - 0.056 13.7 0.6 0.056 13.7 0.6 4.1 3 1 0 3 3 3 0 Homeobox associated leucine zipper HOOK PF05622.12 KOO31061.1 - 0.33 9.0 20.1 0.19 9.9 12.7 2.2 2 0 0 2 2 2 0 HOOK protein FAM76 PF16046.5 KOO31061.1 - 1.5 8.2 10.9 0.69 9.2 3.9 2.1 2 0 0 2 2 2 0 FAM76 protein Fez1 PF06818.15 KOO31061.1 - 2 8.8 22.5 1.1 9.7 10.8 2.3 2 0 0 2 2 2 0 Fez1 TPT PF03151.16 KOO31062.1 - 1.2e-22 80.7 19.8 1.4e-22 80.4 19.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO31062.1 - 5.1e-15 55.9 29.6 9.2e-09 35.6 11.9 2.8 2 1 1 3 3 3 2 EamA-like transporter family EF-hand_1 PF00036.32 KOO31066.1 - 4.8e-16 57.0 0.9 2.3e-06 26.8 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO31066.1 - 3.1e-12 46.2 1.6 1.8e-11 43.7 0.4 2.5 1 1 1 2 2 2 2 EF-hand domain pair Helicase_C PF00271.31 KOO31066.1 - 3.2e-12 46.8 0.0 1.7e-11 44.5 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain EF-hand_6 PF13405.6 KOO31066.1 - 6.7e-12 44.3 0.3 1.5e-05 24.5 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO31066.1 - 3e-11 43.6 0.2 1.2e-10 41.7 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO31066.1 - 9.4e-09 34.4 2.1 0.00022 20.5 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 KOO31066.1 - 1.2e-05 25.5 0.0 2.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO31066.1 - 0.013 15.8 0.0 0.19 12.0 0.0 2.4 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO31066.1 - 0.04 13.9 0.0 0.08 12.9 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand BAF PF02961.14 KOO31067.1 - 0.0013 19.1 0.0 0.0017 18.8 0.0 1.2 1 0 0 1 1 1 1 Barrier to autointegration factor HHH_5 PF14520.6 KOO31067.1 - 0.0021 18.6 0.0 0.0037 17.9 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_8 PF14716.6 KOO31067.1 - 0.14 12.6 0.2 0.37 11.2 0.1 1.7 1 1 1 2 2 2 0 Helix-hairpin-helix domain GST_N PF02798.20 KOO31068.1 - 0.014 15.7 0.0 0.049 14.0 0.0 2.0 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 KOO31068.1 - 0.022 15.3 0.5 0.048 14.2 0.2 1.9 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Methyltransf_16 PF10294.9 KOO31070.1 - 1.4e-11 44.5 0.0 1.9e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase zf-C3H2C3 PF17122.5 KOO31071.1 - 4.5e-06 26.6 12.9 8.3e-06 25.7 12.9 1.5 1 0 0 1 1 1 1 Zinc-finger VPS11_C PF12451.8 KOO31071.1 - 1e-05 25.7 0.2 1.8e-05 24.9 0.2 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal HTH_18 PF12833.7 KOO31071.1 - 0.023 14.9 0.2 0.13 12.5 0.2 2.3 1 0 0 1 1 1 0 Helix-turn-helix domain Clathrin PF00637.20 KOO31071.1 - 0.033 14.1 0.0 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 KOO31071.1 - 0.033 14.0 10.7 0.064 13.1 10.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO31071.1 - 0.065 13.6 9.9 0.15 12.4 9.9 1.7 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 KOO31071.1 - 0.33 11.0 8.5 0.87 9.6 8.5 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO31071.1 - 0.33 11.0 8.4 0.74 9.9 8.4 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 KOO31071.1 - 1.9 8.9 10.1 4 7.8 10.1 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOO31071.1 - 2.3 8.2 9.0 5.1 7.1 9.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DnaJ PF00226.31 KOO31072.1 - 2.1e-15 56.6 0.3 3.4e-14 52.7 0.3 2.7 1 1 0 1 1 1 1 DnaJ domain Myb_DNA-binding PF00249.31 KOO31072.1 - 1.6e-12 47.4 3.9 7e-08 32.5 0.4 2.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO31072.1 - 2.1e-06 27.9 0.0 0.015 15.6 0.0 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Ion_trans PF00520.31 KOO31074.1 - 1.4e-33 116.2 19.3 1.7e-33 115.8 19.3 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO31074.1 - 9.7e-05 21.2 10.7 0.00017 20.4 3.4 2.1 2 0 0 2 2 2 2 Polycystin cation channel PKcGMP_CC PF16808.5 KOO31076.1 - 0.28 11.1 7.1 0.25 11.2 2.1 3.2 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase XhlA PF10779.9 KOO31076.1 - 0.4 10.9 2.0 1.3 9.2 0.2 2.6 2 0 0 2 2 2 0 Haemolysin XhlA Ank_2 PF12796.7 KOO31079.1 - 1.1e-25 90.0 1.0 1.7e-14 54.2 0.0 2.8 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO31079.1 - 2.4e-19 67.4 0.5 0.00033 20.9 0.0 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 KOO31079.1 - 4e-18 65.5 0.0 2e-07 31.4 0.0 3.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO31079.1 - 8.8e-16 57.6 3.9 0.00058 20.2 0.0 5.4 4 1 1 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KOO31079.1 - 4.1e-13 49.3 2.4 7.6e-05 22.9 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO31080.1 - 4.1e-22 78.0 1.1 2.3e-08 34.1 0.0 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO31080.1 - 1.9e-15 57.2 1.0 6.7e-08 33.0 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO31080.1 - 7.9e-13 48.6 1.7 3.3e-06 27.5 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO31080.1 - 2.2e-12 46.8 0.8 0.00033 21.0 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 KOO31080.1 - 3.5e-11 42.3 0.0 0.0042 17.5 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat DUF2520 PF10728.9 KOO31080.1 - 0.44 10.3 2.7 1.1 9.1 0.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF2520) Flexi_CP_N PF08358.10 KOO31081.1 - 0.099 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Carlavirus coat Pentapeptide_4 PF13599.6 KOO31081.1 - 0.22 11.7 0.0 19 5.5 0.0 2.6 3 0 0 3 3 3 0 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.18 KOO31081.1 - 0.5 10.2 6.5 18 5.1 0.1 4.5 4 1 0 5 5 5 0 Ribosomal protein L13e Pkinase_Tyr PF07714.17 KOO31082.1 - 6.3e-36 124.0 0.0 7.6e-36 123.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO31082.1 - 8.6e-33 113.8 0.0 1.2e-32 113.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO31082.1 - 0.029 14.3 1.1 0.11 12.4 1.0 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO31082.1 - 0.068 11.9 0.0 0.097 11.4 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase PP2C PF00481.21 KOO31083.1 - 9.3e-29 100.8 0.0 1.1e-28 100.6 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO31083.1 - 1.1e-06 28.7 0.5 0.0023 17.9 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KOO31083.1 - 2.9e-05 23.8 0.6 0.00033 20.4 0.6 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C EF-hand_5 PF13202.6 KOO31084.1 - 2e-06 27.0 6.1 0.00024 20.5 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 KOO31084.1 - 5.6e-06 25.5 3.2 0.0016 17.9 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO31084.1 - 0.011 15.6 1.4 0.31 10.9 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO31084.1 - 0.018 14.9 2.9 0.25 11.4 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain VCBS PF13517.6 KOO31084.1 - 0.092 13.3 1.4 3.3 8.4 0.1 2.6 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_7 PF13499.6 KOO31084.1 - 0.23 11.9 2.7 0.72 10.3 0.0 2.8 3 1 0 3 3 3 0 EF-hand domain pair Dockerin_1 PF00404.18 KOO31084.1 - 0.31 11.3 1.6 32 4.8 0.0 2.9 3 0 0 3 3 3 0 Dockerin type I domain FG-GAP PF01839.23 KOO31084.1 - 5.6 7.2 9.0 19 5.5 0.4 2.7 2 0 0 2 2 2 0 FG-GAP repeat CAP_N PF01213.19 KOO31084.1 - 8 5.8 8.0 13 5.1 8.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Pkinase PF00069.25 KOO31086.1 - 6.8e-38 130.5 0.0 1.9e-35 122.5 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31086.1 - 3.7e-31 108.3 0.0 5.4e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO31086.1 - 0.046 13.6 0.2 1.6 8.6 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Strumpellin PF10266.9 KOO31087.1 - 0 1080.1 6.9 1e-181 606.3 8.5 2.0 1 1 1 2 2 2 2 Hereditary spastic paraplegia protein strumpellin UCR_hinge PF02320.16 KOO31087.1 - 0.088 13.0 1.3 0.22 11.8 1.3 1.6 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein YlbD_coat PF14071.6 KOO31087.1 - 1.8 8.9 4.7 2.3 8.5 2.5 2.3 2 0 0 2 2 2 0 Putative coat protein EF-hand_6 PF13405.6 KOO31089.1 - 1.5e-50 164.8 13.0 0.00016 21.4 0.1 11.8 12 0 0 12 12 12 10 EF-hand domain EF-hand_1 PF00036.32 KOO31089.1 - 1e-48 159.3 24.3 3.5e-05 23.0 0.0 11.4 11 0 0 11 11 11 10 EF hand EF-hand_7 PF13499.6 KOO31089.1 - 8.3e-45 151.1 6.9 1.2e-07 32.1 0.2 7.0 7 1 0 7 7 7 6 EF-hand domain pair EF-hand_8 PF13833.6 KOO31089.1 - 5.2e-34 115.9 16.0 1.3e-05 24.9 0.0 9.2 7 2 2 9 9 9 7 EF-hand domain pair EF-hand_5 PF13202.6 KOO31089.1 - 4e-29 98.8 33.6 0.00013 21.3 0.2 10.5 10 0 0 10 10 10 7 EF hand EF-hand_11 PF08976.11 KOO31089.1 - 1.2e-11 45.4 0.0 0.00018 22.4 0.0 5.7 4 1 2 6 6 6 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO31089.1 - 4.7e-05 23.7 0.0 4.2 7.7 0.0 4.9 5 0 0 5 5 5 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO31089.1 - 0.00012 22.3 0.5 18 5.7 0.0 5.6 6 1 1 7 7 7 0 EF-hand domain EF-hand_10 PF14788.6 KOO31089.1 - 0.001 18.9 1.6 24 4.9 0.0 5.5 6 0 0 6 6 6 0 EF hand EF-hand_9 PF14658.6 KOO31089.1 - 0.0075 16.6 0.7 3.2 8.2 0.0 4.7 5 1 2 7 7 7 1 EF-hand domain CCD48 PF15799.5 KOO31089.1 - 0.11 10.8 1.9 3.1 6.0 0.0 3.7 3 1 0 4 4 4 0 Coiled-coil domain-containing protein 48 EspA PF03433.13 KOO31089.1 - 0.19 11.5 0.7 15 5.3 0.0 3.4 2 2 2 4 4 4 0 EspA-like secreted protein TPR_2 PF07719.17 KOO31090.1 - 1.1e-17 62.7 26.6 0.00024 21.0 0.3 8.8 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31090.1 - 3.1e-17 61.3 15.9 6.7e-05 22.8 0.0 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO31090.1 - 1.6e-14 54.3 37.8 0.00053 20.6 3.0 6.0 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOO31090.1 - 5.4e-13 48.2 16.0 0.00089 19.0 0.1 7.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO31090.1 - 9.7e-13 47.8 47.9 0.0029 18.3 2.5 10.0 4 4 5 9 9 9 7 Tetratricopeptide repeat TPR_12 PF13424.6 KOO31090.1 - 2.9e-11 43.5 35.7 0.0009 19.5 1.0 7.2 2 2 4 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO31090.1 - 3.5e-11 43.5 37.0 0.0048 17.4 2.8 7.4 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOO31090.1 - 1.1e-08 34.6 16.9 0.18 11.5 0.3 6.5 4 2 2 6 6 6 3 TPR repeat ANAPC3 PF12895.7 KOO31090.1 - 1.3e-06 28.6 17.6 0.004 17.4 0.2 5.2 3 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KOO31090.1 - 3.7e-06 26.6 23.4 0.89 9.7 0.0 8.4 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO31090.1 - 1.4e-05 25.1 12.0 10 6.8 0.0 7.6 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO31090.1 - 0.00012 22.3 40.2 2.7 8.9 0.9 8.2 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_15 PF13429.6 KOO31090.1 - 0.0054 16.0 16.6 0.043 13.0 1.8 3.6 2 2 1 3 3 3 2 Tetratricopeptide repeat C2 PF00168.30 KOO31090.1 - 0.0079 16.5 0.0 0.019 15.2 0.0 1.7 2 0 0 2 2 1 1 C2 domain TPR_9 PF13371.6 KOO31090.1 - 0.015 15.4 24.1 0.059 13.5 1.9 5.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 KOO31090.1 - 0.03 14.3 1.8 5.4 7.1 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO31090.1 - 0.16 12.7 0.2 0.16 12.7 0.2 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat NARP1 PF12569.8 KOO31090.1 - 0.18 10.6 0.8 0.73 8.7 0.1 2.2 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 TPR_21 PF09976.9 KOO31090.1 - 0.18 11.5 16.7 0.11 12.2 5.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 KOO31090.1 - 0.46 10.4 25.0 9 6.3 0.0 6.5 7 0 0 7 7 6 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 KOO31090.1 - 2.6 7.0 3.8 1 8.3 0.2 1.9 2 0 0 2 2 2 0 Coatomer WD associated region Myosin_head PF00063.21 KOO31091.1 - 9.9e-245 813.9 0.1 9.9e-245 813.9 0.1 1.6 2 0 0 2 2 2 1 Myosin head (motor domain) IQ PF00612.27 KOO31091.1 - 0.00029 20.4 51.9 0.012 15.4 2.3 6.8 6 0 0 6 6 6 4 IQ calmodulin-binding motif AAA_16 PF13191.6 KOO31091.1 - 0.00043 20.7 0.0 0.00043 20.7 0.0 4.2 4 1 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 KOO31091.1 - 0.35 11.1 0.0 0.35 11.1 0.0 4.5 3 2 2 6 6 6 0 AAA domain Phage_int_SAM_1 PF02899.17 KOO31092.1 - 0.0076 16.5 0.0 0.026 14.8 0.0 1.9 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 KOO31092.1 - 0.015 15.8 0.0 0.029 14.9 0.0 1.4 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain RVT_1 PF00078.27 KOO31093.1 - 5.7e-06 26.0 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DnaG_DnaB_bind PF08278.11 KOO31093.1 - 0.068 13.8 0.8 3.2 8.4 0.1 2.8 2 1 0 2 2 2 0 DNA primase DnaG DnaB-binding Glyco_hydro_76 PF03663.14 KOO31094.1 - 3.1e-22 79.6 6.1 5.3e-22 78.8 6.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 KOO31094.1 - 0.001 18.2 0.3 0.003 16.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyl Hydrolase Family 88 Bromodomain PF00439.25 KOO31095.1 - 1.1e-25 89.5 0.0 1.6e-13 50.5 0.0 2.8 2 1 1 3 3 3 2 Bromodomain Cut12 PF11500.8 KOO31096.1 - 0.00062 19.7 0.9 0.00062 19.7 0.9 2.0 3 0 0 3 3 3 1 Spindle pole body formation-associated protein DUF1244 PF06844.11 KOO31096.1 - 0.68 10.1 6.0 0.87 9.8 1.8 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) LRR_4 PF12799.7 KOO31097.1 - 3.6e-10 39.9 4.0 2.2 8.8 0.2 6.9 7 1 0 7 7 7 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO31097.1 - 6.2e-10 38.3 32.2 0.3 11.3 0.1 12.0 13 0 0 13 13 13 3 Leucine Rich repeat NACHT PF05729.12 KOO31097.1 - 6.1e-06 26.2 0.1 1.2e-05 25.3 0.1 1.4 1 0 0 1 1 1 1 NACHT domain LRR_1 PF00560.33 KOO31097.1 - 0.001 19.3 2.3 76 4.5 0.0 6.9 9 0 0 9 9 9 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO31097.1 - 0.005 16.6 5.9 50 3.8 0.0 6.2 5 1 0 5 5 5 0 Leucine rich repeat AAA_19 PF13245.6 KOO31097.1 - 0.12 12.7 0.1 0.44 10.9 0.1 1.9 1 0 0 1 1 1 0 AAA domain AdoHcyase PF05221.17 KOO31098.1 - 6.5e-134 445.8 0.1 8.4e-134 445.4 0.1 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase MTHFR PF02219.17 KOO31098.1 - 1e-91 307.2 0.0 3.3e-91 305.6 0.0 1.9 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase AdoHcyase_NAD PF00670.21 KOO31098.1 - 1.5e-77 259.2 4.3 2.5e-77 258.5 4.3 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KOO31098.1 - 5.9e-05 22.5 0.5 0.00011 21.6 0.5 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KOO31098.1 - 0.0027 17.3 0.3 0.0047 16.5 0.3 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain ELFV_dehydrog PF00208.21 KOO31098.1 - 0.017 14.8 0.2 0.043 13.5 0.2 1.6 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase UPF0180 PF03698.13 KOO31098.1 - 0.05 13.8 0.8 0.14 12.3 0.8 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) NAD_binding_7 PF13241.6 KOO31098.1 - 0.055 13.9 0.2 0.16 12.4 0.2 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.18 KOO31098.1 - 0.13 12.6 1.1 0.68 10.2 1.1 2.2 1 1 0 1 1 1 0 TrkA-N domain TFIIA PF03153.13 KOO31099.1 - 0.033 14.2 14.7 0.048 13.6 14.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EIF4E-T PF10477.9 KOO31099.1 - 0.63 8.8 12.2 8.1 5.1 14.4 1.7 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E NPR3 PF03666.13 KOO31099.1 - 1.4 7.6 8.3 2.2 7.0 8.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TSC22 PF01166.18 KOO31099.1 - 6.2 7.2 8.9 4.7 7.6 1.3 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family Ndc1_Nup PF09531.10 KOO31099.1 - 7.5 5.1 8.1 12 4.5 8.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FA_desaturase PF00487.24 KOO31100.1 - 9e-22 78.1 37.5 1.9e-21 77.1 37.5 1.5 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 KOO31100.1 - 1.5e-05 25.0 0.0 5.3e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Pkinase PF00069.25 KOO31101.1 - 7.3e-68 228.8 0.0 1.4e-67 227.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31101.1 - 1e-34 120.0 0.0 1.6e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO31101.1 - 0.00075 18.9 0.0 0.0016 17.8 0.0 1.7 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KOO31101.1 - 0.0022 18.0 1.0 0.072 13.0 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KOO31101.1 - 0.0047 16.3 0.0 0.0081 15.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family OmpH PF03938.14 KOO31101.1 - 0.017 15.4 3.2 0.061 13.7 3.2 1.9 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SAM_Ste50p PF09235.10 KOO31101.1 - 0.16 12.3 0.4 0.52 10.6 0.4 1.9 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Spc7 PF08317.11 KOO31101.1 - 0.48 9.3 6.6 0.85 8.4 6.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Fez1 PF06818.15 KOO31101.1 - 1 9.8 5.8 0.17 12.3 1.5 1.8 2 0 0 2 2 2 0 Fez1 DUF3584 PF12128.8 KOO31101.1 - 1.1 6.6 6.9 1.7 6.0 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) UPF0242 PF06785.11 KOO31101.1 - 5 7.2 6.4 14 5.7 6.4 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Methyltransf_21 PF05050.12 KOO31105.1 - 2e-09 37.7 0.0 3.4e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain V_cholerae_RfbT PF05575.11 KOO31105.1 - 0.01 15.1 0.1 0.045 13.0 0.1 1.8 1 1 0 1 1 1 0 Vibrio cholerae RfbT protein Methyltransf_23 PF13489.6 KOO31105.1 - 0.023 14.5 0.0 0.047 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain NOC3p PF07540.11 KOO31107.1 - 5e-24 84.6 0.2 1e-23 83.6 0.2 1.5 1 0 0 1 1 1 1 Nucleolar complex-associated protein DUF3306 PF11748.8 KOO31107.1 - 2.7 8.9 8.2 0.62 10.9 4.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Metallophos PF00149.28 KOO31109.1 - 2.3e-06 28.3 0.0 5.5e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase AAA PF00004.29 KOO31111.1 - 3.1e-20 72.9 0.0 5.2e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 KOO31111.1 - 1.4e-15 57.8 0.2 2.1e-15 57.2 0.2 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA_16 PF13191.6 KOO31111.1 - 9.4e-06 26.1 0.4 2.8e-05 24.6 0.4 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 KOO31111.1 - 0.001 19.3 0.0 0.0021 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOO31111.1 - 0.0018 18.5 0.0 0.0049 17.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO31111.1 - 0.0026 17.6 0.0 0.0038 17.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KOO31111.1 - 0.0027 17.5 0.0 0.0045 16.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOO31111.1 - 0.0078 16.5 0.0 0.026 14.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KOO31111.1 - 0.0095 15.9 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KOO31111.1 - 0.03 13.9 0.1 0.071 12.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 KOO31111.1 - 0.042 13.1 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_18 PF13238.6 KOO31111.1 - 0.044 14.3 0.0 0.068 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KOO31111.1 - 0.045 13.8 0.0 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 KOO31111.1 - 0.06 12.7 0.0 0.095 12.0 0.0 1.2 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 KOO31111.1 - 0.061 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 KOO31111.1 - 0.14 12.6 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 KOO31111.1 - 0.14 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 KOO31111.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOO31111.1 - 0.15 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region IPT PF01745.16 KOO31111.1 - 0.19 11.1 0.0 0.29 10.5 0.0 1.2 1 0 0 1 1 1 0 Isopentenyl transferase DNA_pol_B PF00136.21 KOO31115.1 - 1.8e-138 462.1 0.1 2.5e-138 461.7 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KOO31115.1 - 4.9e-73 246.2 0.0 7.7e-73 245.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 KOO31115.1 - 8.9e-05 22.9 0.8 0.00021 21.7 0.8 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 KOO31115.1 - 0.035 13.0 0.0 0.061 12.2 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral WD40 PF00400.32 KOO31116.1 - 4.6e-91 296.3 21.9 2.7e-09 37.5 0.3 10.4 10 0 0 10 10 10 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO31116.1 - 5.3e-25 87.5 6.0 0.0095 16.2 0.0 9.0 1 1 8 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO31116.1 - 5.4e-22 77.2 3.9 0.45 10.5 0.0 8.5 8 0 0 8 8 8 6 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 KOO31116.1 - 3.3e-19 69.0 13.9 0.07 12.1 0.0 8.2 1 1 7 8 8 8 7 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 KOO31116.1 - 1.2e-13 50.3 0.0 0.042 12.2 0.0 5.4 1 1 5 6 6 6 4 WD repeat-containing and planar cell polarity effector protein Fritz BBS2_Mid PF14783.6 KOO31116.1 - 1.3e-12 47.7 5.3 0.074 13.1 0.0 8.2 1 1 7 8 8 8 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 KOO31116.1 - 9.2e-08 31.8 5.1 0.0065 15.8 0.1 5.6 2 1 4 6 6 6 1 WD40-like domain Dfp1_Him1_M PF08630.10 KOO31116.1 - 7.5e-06 26.2 2.5 8.9 6.5 0.0 6.2 7 0 0 7 7 7 1 Dfp1/Him1, central region CPSF_A PF03178.15 KOO31116.1 - 0.012 14.9 0.2 0.88 8.8 0.0 2.8 2 2 1 3 3 3 0 CPSF A subunit region DUF3261 PF11659.8 KOO31116.1 - 0.018 14.9 0.0 12 5.7 0.0 4.2 1 1 1 4 4 4 0 Protein of unknown function (DUF3261) Utp8 PF10395.9 KOO31116.1 - 0.027 13.0 2.1 3.2 6.1 0.1 2.8 1 1 1 2 2 2 0 Utp8 family WD40_3 PF15911.5 KOO31116.1 - 0.028 14.4 1.3 81 3.3 0.0 5.9 9 0 0 9 9 9 0 WD domain, G-beta repeat dsrm PF00035.26 KOO31116.1 - 0.057 14.1 0.1 7.7 7.3 0.0 4.1 5 0 0 5 5 4 0 Double-stranded RNA binding motif Spc110_C PF18520.1 KOO31116.1 - 0.1 12.2 0.9 48 3.7 0.0 4.8 6 0 0 6 6 6 0 Spindle pole body component 110 C-terminal domain DUF2222 PF09984.9 KOO31116.1 - 0.14 12.0 0.3 8.6 6.2 0.0 3.4 4 0 0 4 4 4 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) rOmpB PF12334.8 KOO31116.1 - 0.18 11.3 5.6 14 5.0 0.0 5.4 1 1 6 7 7 7 0 Rickettsia outer membrane protein B bPH_4 PF06713.11 KOO31116.1 - 0.2 11.8 1.9 22 5.2 0.1 4.3 4 1 1 5 5 4 0 Bacterial PH domain YflT PF11181.8 KOO31116.1 - 0.28 11.7 6.1 91 3.7 0.0 4.9 3 1 2 5 5 5 0 Heat induced stress protein YflT YhzD PF14120.6 KOO31116.1 - 0.66 10.1 3.4 1e+02 3.1 0.0 6.0 9 3 1 10 10 5 0 YhzD-like protein DUF2621 PF11084.8 KOO31116.1 - 1.8 8.6 3.4 2e+02 1.9 0.0 4.7 4 2 2 6 6 5 0 Protein of unknown function (DUF2621) Aldo_ket_red PF00248.21 KOO31117.1 - 3.3e-17 62.6 0.0 5.4e-10 39.0 0.0 2.1 1 1 1 2 2 2 2 Aldo/keto reductase family LSDAT_euk PF18139.1 KOO31118.1 - 1.8e-18 66.9 0.4 5.3e-15 55.5 0.1 2.2 1 1 1 2 2 2 2 SLOG in TRPM LSDAT_prok PF18171.1 KOO31118.1 - 1.8e-12 46.9 0.2 1.2e-06 27.9 0.1 2.5 1 1 1 2 2 2 2 SLOG in TRPM, prokaryote Ion_trans PF00520.31 KOO31118.1 - 0.0001 21.6 4.3 0.13 11.5 0.3 2.2 1 1 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 KOO31118.1 - 0.00047 19.0 0.2 0.00047 19.0 0.2 1.5 2 0 0 2 2 2 1 Polycystin cation channel DUF1910 PF08928.10 KOO31118.1 - 0.004 17.1 0.5 0.01 15.8 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1910) Nmad5 PF18757.1 KOO31118.1 - 0.041 14.1 0.0 0.041 14.1 0.0 1.8 2 0 0 2 2 2 0 Nucleotide modification associated domain 5 LD_cluster2 PF18163.1 KOO31118.1 - 0.07 12.7 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 SLOG cluster2 Cauli_AT PF03233.13 KOO31118.1 - 0.15 12.0 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Aphid transmission protein HATPase_c PF02518.26 KOO31120.1 - 0.0042 17.6 0.0 0.03 14.8 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOO31120.1 - 0.018 15.2 0.0 0.053 13.7 0.0 1.9 1 1 0 1 1 1 0 Response regulator receiver domain 5TM-5TMR_LYT PF07694.12 KOO31120.1 - 0.14 11.7 3.0 0.17 11.4 0.3 2.2 2 1 0 2 2 2 0 5TMR of 5TMR-LYT PHD PF00628.29 KOO31121.1 - 1.7e-10 40.6 8.2 2.4e-10 40.1 8.2 1.2 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 KOO31121.1 - 0.00023 21.3 1.0 0.00039 20.6 1.0 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-PHD-like PF15446.6 KOO31121.1 - 0.00043 19.9 1.1 0.00069 19.3 1.1 1.3 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain zf-HC5HC2H_2 PF13832.6 KOO31121.1 - 0.24 11.6 4.5 0.43 10.7 4.4 1.5 1 1 0 1 1 1 0 PHD-zinc-finger like domain PHD_4 PF16866.5 KOO31121.1 - 2.7 8.1 10.8 21 5.3 10.8 2.1 1 1 0 1 1 1 0 PHD-finger PHD_2 PF13831.6 KOO31121.1 - 3 7.5 8.4 0.071 12.7 1.7 1.7 2 0 0 2 2 2 0 PHD-finger DUF4978 PF16349.5 KOO31122.1 - 0.058 13.0 0.1 0.16 11.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4978) DUF2577 PF10844.8 KOO31122.1 - 0.24 11.6 1.4 2.3 8.5 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2577) SLATT_6 PF18169.1 KOO31122.1 - 3.2 7.3 5.9 0.51 9.9 0.9 2.3 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 Type2_restr_D3 PF16902.5 KOO31122.1 - 3.7 7.5 6.0 1.1 9.2 0.2 3.0 3 0 0 3 3 3 0 Type-2 restriction enzyme D3 domain AAA_12 PF13087.6 KOO31124.1 - 1.6e-30 106.2 0.0 5.2e-21 75.2 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 KOO31124.1 - 1.2e-09 38.3 0.6 3.7e-09 36.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOO31124.1 - 0.0039 16.9 0.0 0.0039 16.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain DEC-1_N PF04625.13 KOO31124.1 - 0.084 11.9 5.5 0.18 10.7 5.5 1.5 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Abhydrolase_3 PF07859.13 KOO31126.1 - 2.5e-26 92.9 0.3 3.9e-26 92.2 0.3 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 KOO31126.1 - 2.7e-05 23.2 0.0 0.049 12.5 0.0 2.0 2 0 0 2 2 2 2 Steryl acetyl hydrolase DUF3999 PF13163.6 KOO31127.1 - 0.057 12.6 0.1 0.066 12.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3999) UCH PF00443.29 KOO31128.1 - 4.3e-23 82.1 0.0 7.8e-11 41.9 0.0 2.3 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO31128.1 - 3.2e-05 23.7 0.0 0.84 9.2 0.0 3.1 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase Nucleotid_trans PF03407.16 KOO31129.1 - 5.1e-31 108.3 0.0 7.6e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase 2OG-FeII_Oxy_3 PF13640.6 KOO31130.1 - 4e-10 40.4 0.0 6.6e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 KOO31130.1 - 0.0024 18.2 0.0 0.004 17.4 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy PF03171.20 KOO31130.1 - 0.008 16.6 0.0 0.015 15.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RRM_1 PF00076.22 KOO31131.1 - 4.5e-17 61.6 0.0 7.1e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KASH_CCD PF14662.6 KOO31131.1 - 0.023 14.5 5.1 0.04 13.8 5.1 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Nup35_RRM_2 PF14605.6 KOO31131.1 - 0.032 14.2 0.1 0.075 13.0 0.0 1.6 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif WD40_alt PF14077.6 KOO31131.1 - 0.032 14.1 2.1 0.067 13.1 2.1 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif Laminin_II PF06009.12 KOO31131.1 - 0.07 13.1 0.7 0.14 12.2 0.7 1.4 1 0 0 1 1 1 0 Laminin Domain II BLOC1_2 PF10046.9 KOO31131.1 - 0.12 12.7 2.2 0.23 11.8 2.2 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec3_C_2 PF15278.6 KOO31131.1 - 0.12 12.7 1.6 0.32 11.4 1.5 1.7 2 0 0 2 2 2 0 Sec3 exocyst complex subunit NPV_P10 PF05531.12 KOO31131.1 - 0.19 12.2 0.5 0.37 11.3 0.5 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein PSII_Pbs31 PF18240.1 KOO31132.1 - 2.9e-32 111.0 7.7 4.7e-32 110.3 7.7 1.3 1 0 0 1 1 1 1 Photosystem II Psb31 protein Glyco_hydro_9 PF00759.19 KOO31132.1 - 0.21 11.0 5.3 0.26 10.7 5.3 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 zf-CCCH PF00642.24 KOO31133.1 - 2.6e-06 27.2 4.6 4e-06 26.6 4.6 1.2 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOO31133.1 - 6.1e-06 26.1 6.6 9.8e-06 25.5 6.6 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KOO31133.1 - 1.4e-05 24.8 5.3 2e-05 24.2 5.3 1.2 1 0 0 1 1 1 1 CCCH-type zinc finger Retinal PF15449.6 KOO31133.1 - 0.062 11.1 7.6 0.074 10.8 7.6 1.0 1 0 0 1 1 1 0 Retinal protein zf-CCCH_2 PF14608.6 KOO31133.1 - 0.069 13.6 3.7 0.1 13.1 3.7 1.3 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 KOO31133.1 - 0.21 12.3 1.7 0.42 11.3 1.7 1.5 1 0 0 1 1 1 0 Torus domain YrhK PF14145.6 KOO31134.1 - 0.3 11.0 19.0 1.4 8.8 0.9 4.1 5 0 0 5 5 5 0 YrhK-like protein Abhydrolase_6 PF12697.7 KOO31135.1 - 1.7e-13 51.7 7.8 2.3e-13 51.3 7.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO31135.1 - 6.6e-11 41.9 0.0 1e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO31135.1 - 0.0008 19.1 0.0 0.018 14.7 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold TPR_21 PF09976.9 KOO31135.1 - 0.18 11.5 0.5 1.1 8.9 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain Dynamin_N PF00350.23 KOO31136.1 - 1.5e-13 51.1 0.0 6.6e-13 49.1 0.0 2.1 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KOO31136.1 - 2.4e-05 24.4 0.0 0.002 18.2 0.0 3.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO31136.1 - 0.0018 18.2 0.0 0.0049 16.8 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase IIGP PF05049.13 KOO31136.1 - 0.0025 16.9 0.0 0.0085 15.2 0.0 1.7 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) T2SSE PF00437.20 KOO31136.1 - 0.0039 16.3 0.0 0.01 14.9 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 KOO31136.1 - 0.0096 16.4 0.2 0.028 15.0 0.2 1.7 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 KOO31136.1 - 0.016 14.9 0.9 0.092 12.5 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_28 PF13521.6 KOO31136.1 - 0.021 15.1 0.7 0.16 12.2 0.1 2.7 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 KOO31136.1 - 0.022 14.1 0.0 0.055 12.8 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family cobW PF02492.19 KOO31136.1 - 0.04 13.5 0.8 0.89 9.1 0.1 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 KOO31136.1 - 0.054 12.8 0.5 0.22 10.8 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin Septin PF00735.18 KOO31136.1 - 0.18 11.1 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Septin Adeno_IVa2 PF02456.15 KOO31136.1 - 0.24 10.2 0.0 0.39 9.5 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_23 PF13476.6 KOO31136.1 - 0.42 11.1 5.2 0.062 13.8 0.5 2.0 2 0 0 2 2 2 0 AAA domain COG2 PF06148.11 KOO31136.1 - 9.9 6.3 6.6 5.9 7.0 0.1 3.3 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Med6 PF04934.14 KOO31137.1 - 9.7e-28 96.6 0.0 1.2e-27 96.3 0.0 1.0 1 0 0 1 1 1 1 MED6 mediator sub complex component Sulfotransfer_3 PF13469.6 KOO31138.1 - 5.7e-06 26.9 0.4 0.0031 17.9 0.3 3.1 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO31138.1 - 0.00071 19.1 0.0 0.0013 18.3 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase domain LRR_8 PF13855.6 KOO31139.1 - 8.9e-18 63.8 27.2 2.2e-08 33.8 1.8 7.4 4 2 3 7 7 7 5 Leucine rich repeat LRR_4 PF12799.7 KOO31139.1 - 1.1e-14 54.3 21.3 1.5e-05 25.2 0.4 7.4 7 0 0 7 7 6 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO31139.1 - 8e-13 47.3 34.2 0.71 10.1 0.0 13.5 13 0 0 13 13 13 4 Leucine Rich repeat Roc PF08477.13 KOO31139.1 - 1.8e-09 37.8 0.0 3.7e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 KOO31139.1 - 0.00024 21.0 0.1 0.0015 18.5 0.0 2.4 2 0 0 2 2 2 1 NACHT domain COR PF16095.5 KOO31139.1 - 0.019 14.8 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 C-terminal of Roc, COR, domain Ras PF00071.22 KOO31139.1 - 0.021 14.4 0.0 0.049 13.2 0.0 1.6 1 0 0 1 1 1 0 Ras family SH3_3 PF08239.11 KOO31139.1 - 0.026 14.8 0.0 4.2 7.7 0.0 2.9 2 0 0 2 2 2 0 Bacterial SH3 domain AAA_19 PF13245.6 KOO31139.1 - 0.078 13.3 1.5 0.14 12.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KOO31139.1 - 0.083 13.3 0.0 0.37 11.2 0.0 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 KOO31139.1 - 0.19 10.8 0.0 0.37 9.9 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit LRR_1 PF00560.33 KOO31139.1 - 0.47 11.2 20.4 16 6.6 0.1 9.5 13 0 0 13 13 9 0 Leucine Rich Repeat UvrD-helicase PF00580.21 KOO31139.1 - 1.3 8.5 4.3 0.71 9.3 0.0 2.4 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain Dynamin_N PF00350.23 KOO31140.1 - 4.5e-15 56.1 0.0 2.1e-14 53.9 0.0 2.0 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KOO31140.1 - 2.8e-07 30.6 0.0 0.00033 20.7 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO31140.1 - 3.3e-05 23.8 0.0 0.00027 20.9 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 KOO31140.1 - 6.8e-05 23.4 0.2 0.00045 20.7 0.0 2.5 2 2 1 3 3 2 1 ABC transporter T2SSE PF00437.20 KOO31140.1 - 0.0038 16.3 3.1 0.012 14.7 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AIG1 PF04548.16 KOO31140.1 - 0.0092 15.3 0.2 0.067 12.5 0.2 2.1 2 0 0 2 2 2 1 AIG1 family AAA_29 PF13555.6 KOO31140.1 - 0.0098 15.6 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 KOO31140.1 - 0.011 15.2 1.7 0.053 12.9 0.0 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_22 PF13401.6 KOO31140.1 - 0.019 15.2 0.0 0.11 12.7 0.0 2.4 2 0 0 2 2 1 0 AAA domain AAA_23 PF13476.6 KOO31140.1 - 0.044 14.3 2.1 0.075 13.5 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO31140.1 - 0.046 14.1 0.0 0.046 14.1 0.0 4.3 3 1 0 3 3 2 0 AAA ATPase domain IIGP PF05049.13 KOO31140.1 - 0.13 11.3 0.0 0.27 10.2 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) GTP_EFTU PF00009.27 KOO31140.1 - 0.13 11.8 0.0 0.51 9.9 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOO31140.1 - 0.15 11.5 0.4 0.81 9.2 0.2 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B cobW PF02492.19 KOO31140.1 - 0.16 11.5 0.2 0.46 10.1 0.2 1.8 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 KOO31140.1 - 0.2 10.9 0.0 0.37 10.0 0.0 1.3 1 0 0 1 1 1 0 Septin LUC7 PF03194.15 KOO31140.1 - 1.3 8.6 3.5 3.2 7.4 3.5 1.6 1 0 0 1 1 1 0 LUC7 N_terminus Period_C PF12114.8 KOO31140.1 - 9.9 5.7 10.7 25 4.4 10.7 1.6 1 0 0 1 1 1 0 Period protein 2/3C-terminal region GST_C PF00043.25 KOO31141.1 - 2.3e-06 27.8 0.0 3.8e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOO31141.1 - 5.7e-06 26.3 0.1 1.4e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOO31141.1 - 1.7e-05 24.9 0.0 3.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOO31141.1 - 0.026 14.9 0.0 0.12 12.8 0.0 2.1 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Dpy-30 PF05186.13 KOO31141.1 - 0.064 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Dpy-30 motif TMEM173 PF15009.6 KOO31141.1 - 0.14 11.2 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 173 SAM_1 PF00536.30 KOO31142.1 - 6.2e-06 26.6 0.1 1.5e-05 25.4 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO31142.1 - 0.00014 21.9 0.1 0.00031 20.8 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) KLRAQ PF10205.9 KOO31142.1 - 3.7 7.8 7.9 1.1 9.5 2.7 2.5 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein FKBP_C PF00254.28 KOO31143.1 - 6.1e-24 84.2 0.0 8.7e-24 83.7 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.6 KOO31143.1 - 2.2e-06 28.0 0.3 4.4e-06 27.1 0.3 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO31143.1 - 1.1e-05 24.6 1.7 0.033 13.7 0.9 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31143.1 - 2.6e-05 23.8 1.0 0.32 11.0 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO31143.1 - 0.0063 16.0 2.8 0.074 12.6 1.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO31143.1 - 0.029 14.2 0.1 1.2 9.0 0.4 2.3 2 0 0 2 2 2 0 EF-hand domain pair Fasciclin PF02469.22 KOO31144.1 - 3.4e-34 117.8 0.0 4.8e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Fasciclin domain HlyIII PF03006.20 KOO31145.1 - 5.3e-19 68.8 18.0 7.5e-19 68.3 18.0 1.2 1 0 0 1 1 1 1 Haemolysin-III related YrhC PF14143.6 KOO31145.1 - 0.16 12.1 0.6 0.53 10.4 0.0 2.1 2 0 0 2 2 2 0 YrhC-like protein MSA-2c PF12238.8 KOO31146.1 - 0.0057 16.7 2.7 0.0058 16.7 2.7 1.1 1 0 0 1 1 1 1 Merozoite surface antigen 2c CAP_N PF01213.19 KOO31146.1 - 0.14 11.6 3.6 0.13 11.7 3.6 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal EF-hand_5 PF13202.6 KOO31147.1 - 3.5e-05 23.1 0.0 6.1e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO31147.1 - 4.9e-05 22.6 0.0 7.5e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO31147.1 - 9.3e-05 22.1 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO31147.1 - 0.031 14.7 0.0 0.052 14.0 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair Toprim_2 PF13155.6 KOO31147.1 - 0.13 12.7 0.0 0.19 12.2 0.0 1.2 1 0 0 1 1 1 0 Toprim-like EF-hand_9 PF14658.6 KOO31147.1 - 0.16 12.3 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain Ribosomal_S10 PF00338.22 KOO31148.1 - 7.5e-31 106.3 0.1 1.1e-30 105.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DHHC PF01529.20 KOO31150.1 - 6.8e-18 65.1 1.9 6.8e-18 65.1 1.9 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase Golgin_A5 PF09787.9 KOO31151.1 - 5.8 6.3 32.7 2 7.8 17.9 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 EF-hand_1 PF00036.32 KOO31155.1 - 1.6e-25 86.7 15.2 0.00021 20.6 0.1 7.4 6 1 1 7 7 7 6 EF hand EF-hand_6 PF13405.6 KOO31155.1 - 1.3e-24 83.9 12.8 0.0039 17.0 0.1 7.4 6 1 1 7 7 7 7 EF-hand domain EF-hand_7 PF13499.6 KOO31155.1 - 4.1e-21 75.2 10.0 4.8e-06 26.9 0.5 6.6 5 2 2 7 7 7 7 EF-hand domain pair EF-hand_5 PF13202.6 KOO31155.1 - 8.3e-21 72.5 11.2 0.00018 20.9 0.1 7.5 7 0 0 7 7 7 5 EF hand EF-hand_8 PF13833.6 KOO31155.1 - 3.6e-11 42.7 10.9 0.0011 18.7 0.3 6.8 6 1 1 7 7 7 5 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO31155.1 - 2.4e-06 27.8 0.8 0.88 9.9 0.0 4.7 3 2 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO31155.1 - 2e-05 24.5 3.8 3.5 7.6 0.0 4.8 3 1 2 5 5 5 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO31155.1 - 0.057 13.6 0.0 0.41 10.9 0.0 2.4 2 0 0 2 2 2 0 Dockerin type I domain DDE_Tnp_IS66 PF03050.14 KOO31157.1 - 0.00086 18.9 0.2 0.002 17.7 0.1 1.6 2 0 0 2 2 2 1 Transposase IS66 family MULE PF10551.9 KOO31157.1 - 0.0039 17.6 0.2 0.025 15.0 0.0 2.3 2 0 0 2 2 2 1 MULE transposase domain BUD22 PF09073.10 KOO31158.1 - 0.0011 18.4 11.2 0.0014 18.1 11.2 1.1 1 0 0 1 1 1 1 BUD22 DUF5442 PF17514.2 KOO31158.1 - 0.035 14.3 0.1 0.084 13.1 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5442) PTPRCAP PF15713.5 KOO31158.1 - 0.35 11.2 11.7 0.15 12.3 5.5 2.4 3 0 0 3 3 3 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 KOO31158.1 - 0.67 8.2 6.4 0.9 7.8 6.4 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4611 PF15387.6 KOO31158.1 - 0.67 10.2 11.5 1.9 8.8 11.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) YL1 PF05764.13 KOO31158.1 - 6.6 6.8 17.2 1.6 8.8 13.9 1.5 2 0 0 2 2 2 0 YL1 nuclear protein DUF2237 PF09996.9 KOO31159.1 - 0.31 11.1 2.8 1.7 8.7 2.8 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) PDZ PF00595.24 KOO31161.1 - 1.9e-23 82.6 0.1 2.6e-06 27.7 0.0 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KOO31161.1 - 1.1e-19 69.9 2.5 1.3e-05 24.9 0.1 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KOO31161.1 - 8e-11 42.1 1.4 0.0076 16.6 0.1 3.5 3 0 0 3 3 3 3 PDZ domain EF-hand_1 PF00036.32 KOO31161.1 - 3.4e-09 35.6 0.1 0.0006 19.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO31161.1 - 4.9e-09 35.9 0.1 1e-08 34.9 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair cNMP_binding PF00027.29 KOO31161.1 - 2.1e-08 34.1 0.1 2.6e-05 24.2 0.1 4.2 2 1 1 3 3 3 1 Cyclic nucleotide-binding domain EF-hand_6 PF13405.6 KOO31161.1 - 3.1e-08 32.9 0.0 0.0027 17.5 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO31161.1 - 1.5e-06 27.4 0.3 0.00027 20.3 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO31161.1 - 0.00011 22.6 0.6 0.13 12.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair DUF4220 PF13968.6 KOO31161.1 - 0.083 12.3 0.1 0.12 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) GLE1 PF07817.13 KOO31162.1 - 9.6e-12 44.6 1.5 1.2e-11 44.3 0.1 1.9 2 0 0 2 2 2 1 GLE1-like protein CDC37_N PF03234.14 KOO31162.1 - 0.0025 18.7 4.5 0.0025 18.7 4.5 3.0 3 1 0 3 3 3 1 Cdc37 N terminal kinase binding Rrn6 PF10214.9 KOO31162.1 - 3.2 6.1 15.3 0.37 9.2 0.5 2.2 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor ERM PF00769.19 KOO31162.1 - 4.6 7.0 35.5 0.019 14.8 15.9 2.7 3 0 0 3 3 3 0 Ezrin/radixin/moesin family DUF572 PF04502.13 KOO31162.1 - 6.2 6.3 15.7 1 8.9 6.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) zf-CXXC PF02008.20 KOO31165.1 - 8.2e-07 28.9 1.6 1.9e-06 27.8 1.6 1.5 1 0 0 1 1 1 1 CXXC zinc finger domain AP2 PF00847.20 KOO31165.1 - 5.1e-06 26.6 8.9 0.1 12.9 0.1 4.6 3 1 0 3 3 3 3 AP2 domain RecQ_Zn_bind PF16124.5 KOO31165.1 - 0.17 12.7 0.6 0.53 11.0 0.1 2.2 2 0 0 2 2 2 0 RecQ zinc-binding NAD_binding_10 PF13460.6 KOO31167.1 - 3.9e-20 72.5 0.5 7.6e-20 71.6 0.1 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 KOO31167.1 - 2.1e-12 47.0 0.0 5.6e-12 45.6 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 KOO31167.1 - 1e-08 35.0 0.2 1.5e-08 34.5 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 KOO31167.1 - 1.7e-06 27.2 0.0 2.8e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KOO31167.1 - 5.9e-05 22.3 0.2 0.00017 20.8 0.2 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain Semialdhyde_dh PF01118.24 KOO31167.1 - 0.0055 17.1 0.1 0.01 16.3 0.1 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 KOO31167.1 - 0.0062 16.8 0.1 0.014 15.7 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 KOO31167.1 - 0.056 12.6 0.3 3.5 6.7 0.1 2.4 2 1 0 2 2 2 0 Male sterility protein Glyco_transf_8 PF01501.20 KOO31168.1 - 6e-11 42.4 0.0 4.6e-10 39.5 0.0 2.5 2 1 0 2 2 2 1 Glycosyl transferase family 8 DUF447 PF04289.12 KOO31169.1 - 0.22 11.3 3.0 0.37 10.6 2.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF447) Draxin PF15550.6 KOO31169.1 - 5.3 6.8 10.6 8.7 6.1 10.6 1.3 1 0 0 1 1 1 0 Draxin TFIIA PF03153.13 KOO31169.1 - 7.2 6.5 24.0 8.3 6.3 24.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PALP PF00291.25 KOO31170.1 - 4.9e-55 187.0 0.1 6.5e-55 186.6 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme RabGAP-TBC PF00566.18 KOO31171.1 - 3.4e-36 124.9 0.1 5.1e-36 124.4 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Macoilin PF09726.9 KOO31172.1 - 0.015 13.9 7.6 0.052 12.1 0.0 2.0 2 0 0 2 2 2 0 Macoilin family LMBR1 PF04791.16 KOO31172.1 - 0.086 11.7 0.6 0.11 11.4 0.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ATG16 PF08614.11 KOO31172.1 - 0.67 10.1 29.9 0.19 11.9 6.6 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) HAUS6_N PF14661.6 KOO31172.1 - 3 7.4 14.9 5.8 6.4 0.7 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DNA_pack_N PF02500.15 KOO31172.1 - 8.3 6.2 7.2 1.1 9.1 0.3 2.1 2 0 0 2 2 2 0 Probable DNA packing protein, N-terminus UPF0370 PF13980.6 KOO31174.1 - 0.11 12.6 0.1 0.11 12.6 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) TPR_11 PF13414.6 KOO31175.1 - 0.00078 19.1 0.0 0.88 9.3 0.0 2.2 2 0 0 2 2 2 2 TPR repeat TPR_16 PF13432.6 KOO31175.1 - 0.0039 17.8 1.1 0.0092 16.6 1.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO31175.1 - 0.0097 16.0 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31175.1 - 0.027 14.6 0.0 0.058 13.6 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO31175.1 - 0.043 14.0 0.5 0.085 13.0 0.5 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO31175.1 - 0.056 14.3 1.3 0.08 13.8 0.3 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat HrpB4 PF09502.10 KOO31175.1 - 0.14 12.0 4.8 0.31 10.8 4.8 1.7 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB4) U-box PF04564.15 KOO31176.1 - 8.9e-19 67.5 0.0 1.3e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO31176.1 - 3.5e-17 62.5 8.4 4.6e-05 24.0 0.1 4.2 4 0 0 4 4 4 3 Sel1 repeat zf-Nse PF11789.8 KOO31176.1 - 0.00012 21.9 0.0 0.00021 21.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit BUD22 PF09073.10 KOO31176.1 - 0.0011 18.4 8.5 0.0015 18.0 8.5 1.1 1 0 0 1 1 1 1 BUD22 zf-NOSIP PF15906.5 KOO31176.1 - 0.13 12.5 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein SAPS PF04499.15 KOO31176.1 - 0.3 9.8 0.9 0.37 9.5 0.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PRP21_like_P PF12230.8 KOO31176.1 - 0.37 10.6 4.7 0.55 10.1 4.7 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein RR_TM4-6 PF06459.12 KOO31176.1 - 1.7 8.4 8.4 2.3 7.9 8.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BAF1_ABF1 PF04684.13 KOO31176.1 - 2.1 7.3 7.7 2.6 7.0 7.7 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Sel1 PF08238.12 KOO31177.1 - 3e-49 164.3 65.4 1.8e-05 25.2 1.0 10.3 10 0 0 10 10 10 10 Sel1 repeat U-box PF04564.15 KOO31177.1 - 2.5e-16 59.6 0.0 3.6e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO31177.1 - 0.00045 20.0 0.0 0.00082 19.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit PRP21_like_P PF12230.8 KOO31177.1 - 0.017 15.0 3.5 0.025 14.4 3.5 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein zf-NOSIP PF15906.5 KOO31177.1 - 0.03 14.5 0.0 0.061 13.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein AmpE PF17113.5 KOO31177.1 - 0.12 11.6 0.1 11 5.2 0.0 3.2 2 1 2 4 4 4 0 Regulatory signalling modulator protein AmpE RR_TM4-6 PF06459.12 KOO31177.1 - 0.24 11.2 6.1 0.36 10.6 6.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Blt1_C PF17183.4 KOO31177.1 - 0.85 9.3 4.8 5.2e+02 0.4 0.0 6.4 9 0 0 9 9 9 0 Get5 carboxyl domain DUF4050 PF13259.6 KOO31177.1 - 1.1 9.5 3.1 1.8 8.9 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) TraV PF09676.10 KOO31177.1 - 8.7 7.3 9.7 59 4.6 9.7 2.2 1 1 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Pkinase PF00069.25 KOO31180.1 - 2.9e-50 171.1 0.0 4.2e-50 170.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31180.1 - 3.1e-42 144.7 0.0 4e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO31180.1 - 0.0034 16.8 0.0 0.0053 16.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO31180.1 - 0.049 12.4 0.0 0.079 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase CDC27 PF09507.10 KOO31181.1 - 8.8e-24 84.7 30.4 3.9e-23 82.5 30.4 2.4 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 TauD PF02668.16 KOO31181.1 - 5.2e-17 62.5 0.3 4e-16 59.6 0.1 2.3 2 1 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family YfiO PF13525.6 KOO31181.1 - 0.047 13.4 0.5 0.1 12.3 0.1 1.6 2 0 0 2 2 2 0 Outer membrane lipoprotein ADPrib_exo_Tox PF03496.14 KOO31183.1 - 4.3e-06 26.2 0.0 0.0093 15.3 0.0 2.6 2 1 0 2 2 2 2 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO31183.1 - 0.13 11.6 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase WLM PF08325.10 KOO31184.1 - 4.1e-35 121.6 0.0 8.4e-35 120.6 0.0 1.5 2 0 0 2 2 2 1 WLM domain ubiquitin PF00240.23 KOO31184.1 - 0.01 15.6 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family DUF45 PF01863.17 KOO31184.1 - 0.019 15.0 0.8 0.038 14.0 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 Ubiquitin_5 PF18037.1 KOO31184.1 - 0.058 13.8 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain BT1 PF03092.16 KOO31185.1 - 7.2e-63 212.6 3.1 1.4e-31 109.4 0.3 2.3 2 0 0 2 2 2 2 BT1 family Ank_2 PF12796.7 KOO31186.1 - 1.7e-21 76.6 0.9 6.7e-11 42.6 0.9 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO31186.1 - 9.5e-21 73.6 1.6 1.2e-06 28.7 0.0 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO31186.1 - 2.7e-14 53.3 0.7 0.0011 19.5 0.0 4.9 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO31186.1 - 2.1e-13 50.0 7.6 0.00021 21.6 0.0 5.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KOO31186.1 - 9.6e-12 44.0 2.9 0.15 12.7 0.0 5.9 5 0 0 5 5 5 5 Ankyrin repeat EutK_C PF16365.5 KOO31186.1 - 0.09 12.8 5.2 11 6.1 0.8 3.9 3 0 0 3 3 3 0 Ethanolamine utilization protein EutK C-terminus Apyrase PF06079.11 KOO31187.1 - 7.4e-68 228.9 0.0 1e-67 228.4 0.0 1.1 1 0 0 1 1 1 1 Apyrase 4HBT_2 PF13279.6 KOO31189.1 - 3.3e-14 53.4 0.0 4.6e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 KOO31189.1 - 1.5e-08 34.8 0.3 4.4e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 KOO31189.1 - 0.015 14.6 0.0 0.029 13.6 0.0 1.4 2 0 0 2 2 2 0 Acyl-ACP thioesterase cNMP_binding PF00027.29 KOO31190.1 - 1.1e-22 79.9 0.0 1.8e-10 40.7 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain DUF2564 PF10819.8 KOO31191.1 - 0.18 12.2 6.9 3.1 8.3 0.6 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2564) PX PF00787.24 KOO31192.1 - 0.049 13.6 0.0 0.094 12.7 0.0 1.4 1 0 0 1 1 1 0 PX domain VapB_antitoxin PF09957.9 KOO31192.1 - 0.13 12.2 4.3 0.39 10.7 0.1 3.5 3 0 0 3 3 3 0 Bacterial antitoxin of type II TA system, VapB SET PF00856.28 KOO31193.1 - 1.1e-19 71.5 0.0 3.5e-19 69.8 0.0 1.9 1 0 0 1 1 1 1 SET domain PHD PF00628.29 KOO31193.1 - 9.6 6.2 33.9 2.5 8.0 12.1 3.6 3 1 0 3 3 3 0 PHD-finger DUF393 PF04134.12 KOO31194.1 - 1.6e-19 71.3 0.0 2.7e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF393 WW PF00397.26 KOO31196.1 - 1.6e-05 24.8 1.1 3.8e-05 23.7 1.1 1.6 1 0 0 1 1 1 1 WW domain TIR PF01582.20 KOO31196.1 - 0.11 12.3 3.1 3.2 7.5 0.0 2.7 2 0 0 2 2 2 0 TIR domain DUF572 PF04502.13 KOO31196.1 - 0.88 9.1 11.3 1.8 8.1 11.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF572) Dynein_light PF01221.18 KOO31196.1 - 0.92 9.9 2.5 1.8 8.9 1.6 2.0 1 1 0 1 1 1 0 Dynein light chain type 1 IQ PF00612.27 KOO31196.1 - 2.1 8.4 5.4 0.65 10.0 0.2 3.0 3 0 0 3 3 3 0 IQ calmodulin-binding motif MatE PF01554.18 KOO31198.1 - 1.8e-48 164.2 35.5 9.4e-26 90.4 11.7 2.1 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 KOO31198.1 - 1.4 9.0 36.8 0.038 14.1 17.6 4.7 2 2 2 4 4 4 0 Polysaccharide biosynthesis C-terminal domain NUP PF06516.11 KOO31199.1 - 2.5e-37 128.8 0.0 2.9e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) TPR_2 PF07719.17 KOO31200.1 - 1e-06 28.4 22.8 0.12 12.6 0.1 6.4 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31200.1 - 1.9e-05 24.5 9.0 0.032 14.4 0.2 5.1 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO31200.1 - 0.00042 20.0 11.6 0.12 12.2 0.1 5.1 4 1 0 4 4 4 2 Tetratricopeptide repeat DUF640 PF04852.12 KOO31200.1 - 0.13 12.5 0.1 0.5 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF640) Terminase_4 PF05119.12 KOO31200.1 - 0.54 10.7 5.1 2.4 8.6 5.1 2.1 1 0 0 1 1 1 0 Phage terminase, small subunit Agenet PF05641.12 KOO31201.1 - 1.6e-07 31.6 0.8 6.1e-07 29.8 0.1 2.3 2 0 0 2 2 2 1 Agenet domain MBD PF01429.19 KOO31201.1 - 0.00069 19.3 0.1 0.002 17.8 0.1 1.7 1 0 0 1 1 1 1 Methyl-CpG binding domain Clr2_transil PF16761.5 KOO31201.1 - 0.051 14.4 0.1 0.12 13.2 0.1 1.5 1 0 0 1 1 1 0 Transcription-silencing protein, cryptic loci regulator Clr2 DUF5017 PF16409.5 KOO31202.1 - 0.0045 16.5 0.2 0.014 14.9 0.1 1.8 1 1 0 2 2 2 1 Domain of unknown function (DUF5017) DUF5093 PF17011.5 KOO31202.1 - 0.15 12.4 0.2 0.52 10.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5093) Ribosomal_60s PF00428.19 KOO31203.1 - 0.41 11.3 5.2 0.52 10.9 5.2 1.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ank_4 PF13637.6 KOO31205.1 - 6.3e-16 58.5 0.2 2e-10 41.0 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO31205.1 - 1.6e-12 47.8 0.0 2.9e-10 40.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO31205.1 - 1.5e-11 44.3 0.7 0.001 19.3 0.0 4.2 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO31205.1 - 4e-11 42.8 0.5 0.00028 21.2 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO31205.1 - 9.8e-11 40.9 0.1 0.006 17.0 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat AA_permease PF00324.21 KOO31206.1 - 1.7e-22 79.7 30.1 1.7e-13 50.0 23.1 2.1 1 1 1 2 2 2 2 Amino acid permease TUDOR_5 PF18359.1 KOO31207.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain 1 Sulphotransf PF09037.10 KOO31207.1 - 0.12 11.9 1.1 0.39 10.2 0.4 2.0 2 0 0 2 2 2 0 Stf0 sulphotransferase zf-RING_5 PF14634.6 KOO31209.1 - 7.4e-06 25.8 3.8 1.8e-05 24.6 3.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KOO31209.1 - 2.3e-05 24.6 2.7 5.3e-05 23.5 2.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOO31209.1 - 5.3e-05 22.9 0.3 0.00011 21.8 0.3 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KOO31209.1 - 5.6e-05 22.9 4.1 0.00019 21.2 4.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO31209.1 - 0.0024 17.9 3.6 0.005 16.8 3.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOO31209.1 - 0.0041 17.0 7.8 0.018 14.9 7.8 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KOO31209.1 - 0.022 14.4 4.0 0.06 13.0 4.0 1.8 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 KOO31209.1 - 0.24 11.7 3.0 0.54 10.6 3.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain KxDL PF10241.9 KOO31209.1 - 0.28 11.5 4.7 0.23 11.8 0.9 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF3797 PF12677.7 KOO31209.1 - 1 9.3 4.3 3.1 7.8 3.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) ZapB PF06005.12 KOO31209.1 - 1.3 9.5 4.4 2.3 8.7 0.8 2.5 2 1 0 2 2 2 0 Cell division protein ZapB zf-RING-like PF08746.11 KOO31209.1 - 1.3 9.4 6.2 0.95 9.8 4.0 2.0 2 0 0 2 2 2 0 RING-like domain VCBS PF13517.6 KOO31212.1 - 1.9e-80 265.4 104.9 4.4e-13 49.6 6.5 9.5 2 2 7 9 9 9 9 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO31212.1 - 5.5e-40 135.1 98.9 0.00028 20.9 1.4 10.7 10 0 0 10 10 10 10 FG-GAP repeat Ephrin_rec_like PF07699.13 KOO31212.1 - 1.5e-15 56.7 93.3 6.2e-08 32.3 2.0 10.5 7 1 6 14 14 14 7 Putative ephrin-receptor like Dockerin_1 PF00404.18 KOO31212.1 - 0.0025 18.0 38.2 36 4.7 0.1 10.0 9 1 1 10 10 10 0 Dockerin type I domain EF-hand_1 PF00036.32 KOO31212.1 - 8 6.3 41.6 25 4.7 0.2 10.1 10 0 0 10 10 10 0 EF hand Pkinase PF00069.25 KOO31213.1 - 3.6e-45 154.4 0.0 5.2e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31213.1 - 8.1e-39 133.4 0.0 1.4e-38 132.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO31213.1 - 0.00021 20.2 0.0 0.00063 18.6 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOO31213.1 - 0.00064 19.1 0.0 0.00096 18.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Ank_5 PF13857.6 KOO31214.1 - 0.00011 22.4 0.3 0.002 18.4 0.1 2.8 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO31214.1 - 0.00019 22.0 0.1 0.00038 21.0 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO31214.1 - 0.00026 21.5 0.2 0.0031 18.1 0.0 1.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO31214.1 - 0.0048 17.3 0.4 0.1 13.2 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 KOO31214.1 - 0.2 12.2 1.2 0.42 11.1 0.2 2.0 2 0 0 2 2 2 0 Ankyrin repeat EF-hand_7 PF13499.6 KOO31215.1 - 2e-15 57.0 7.8 0.00011 22.5 0.0 4.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO31215.1 - 6e-14 50.7 11.3 0.015 15.2 0.0 7.8 7 2 1 8 8 8 3 EF-hand domain EF-hand_1 PF00036.32 KOO31215.1 - 3.6e-13 48.0 10.0 0.0045 16.4 0.0 7.4 7 2 1 8 8 8 3 EF hand EF-hand_8 PF13833.6 KOO31215.1 - 3.5e-10 39.6 0.3 0.0044 16.9 0.0 4.6 3 2 2 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO31215.1 - 1.6e-08 33.7 12.0 0.00096 18.5 0.1 5.5 6 0 0 6 6 6 3 EF hand EF-hand_4 PF12763.7 KOO31215.1 - 2.6 8.0 5.3 6.3 6.8 0.1 3.5 3 2 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand AAA PF00004.29 KOO31216.1 - 1.4e-17 64.3 0.0 3.4e-17 63.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO31216.1 - 1.9e-06 27.9 0.0 4.2e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO31216.1 - 0.00032 21.1 0.1 0.0017 18.8 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 KOO31216.1 - 0.0014 18.8 0.0 0.0038 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO31216.1 - 0.002 18.7 0.0 0.014 15.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO31216.1 - 0.0074 16.6 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO31216.1 - 0.0088 15.9 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOO31216.1 - 0.0096 16.2 0.1 0.04 14.2 0.0 2.0 3 0 0 3 3 2 1 AAA domain Sigma54_activ_2 PF14532.6 KOO31216.1 - 0.023 14.8 0.0 0.12 12.5 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_6 PF12774.7 KOO31216.1 - 0.037 13.0 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region SAM_2 PF07647.17 KOO31216.1 - 0.043 13.9 0.0 0.092 12.9 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SHIRT PF18655.1 KOO31216.1 - 0.074 13.7 0.3 0.31 11.7 0.0 2.1 2 0 0 2 2 2 0 SHIRT domain AAA_25 PF13481.6 KOO31216.1 - 0.076 12.6 0.0 0.68 9.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 KOO31216.1 - 0.085 13.2 0.0 0.23 11.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 KOO31216.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ras PF00071.22 KOO31217.1 - 1.6e-55 187.1 0.0 1.9e-55 186.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO31217.1 - 2.2e-31 108.6 0.0 3.1e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO31217.1 - 4.5e-12 45.8 0.0 5.3e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO31217.1 - 3.7e-07 30.2 0.0 5.7e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOO31217.1 - 8e-05 22.1 0.0 9.8e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KOO31217.1 - 0.00012 22.0 0.0 0.00086 19.2 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_5 PF07728.14 KOO31217.1 - 0.0042 17.1 0.0 0.0072 16.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO31217.1 - 0.0054 17.0 0.0 0.0086 16.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO31217.1 - 0.0056 17.1 0.1 0.013 15.9 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 KOO31217.1 - 0.013 15.3 0.1 0.096 12.4 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 KOO31217.1 - 0.015 14.6 0.1 0.028 13.7 0.1 1.4 1 0 0 1 1 1 0 Septin AAA_7 PF12775.7 KOO31217.1 - 0.016 14.7 0.1 0.025 14.1 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 KOO31217.1 - 0.021 14.6 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KOO31217.1 - 0.023 14.6 0.3 0.057 13.3 0.0 1.7 2 0 0 2 2 2 0 NTPase SRPRB PF09439.10 KOO31217.1 - 0.024 14.1 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit cobW PF02492.19 KOO31217.1 - 0.027 14.0 0.0 0.052 13.1 0.0 1.5 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 KOO31217.1 - 0.07 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TniB PF05621.11 KOO31217.1 - 0.075 12.4 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NB-ARC PF00931.22 KOO31217.1 - 0.094 11.9 0.1 0.15 11.2 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 KOO31217.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain MCM PF00493.23 KOO31217.1 - 0.14 11.2 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain AAA_14 PF13173.6 KOO31217.1 - 0.15 12.1 0.0 0.27 11.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 KOO31217.1 - 0.15 11.8 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 KOO31217.1 - 0.16 12.4 0.0 0.37 11.2 0.0 1.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AFG1_ATPase PF03969.16 KOO31217.1 - 0.17 10.7 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase TPT PF03151.16 KOO31218.1 - 1.6e-05 24.4 17.3 2.2e-05 23.9 17.3 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO31218.1 - 0.00021 21.5 33.1 0.021 15.0 11.6 3.2 2 2 1 3 3 3 2 EamA-like transporter family UAA PF08449.11 KOO31218.1 - 0.0098 15.1 18.2 0.039 13.2 18.0 2.0 1 1 0 1 1 1 1 UAA transporter family Ax_dynein_light PF10211.9 KOO31219.1 - 1.7e-06 28.1 9.4 4.2e-06 26.8 9.4 1.7 1 0 0 1 1 1 1 Axonemal dynein light chain EF-hand_1 PF00036.32 KOO31219.1 - 1.2e-05 24.5 0.2 3.5e-05 23.1 0.2 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO31219.1 - 5.8e-05 22.7 0.0 0.00022 20.9 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO31219.1 - 0.00046 19.5 0.1 0.0021 17.5 0.1 2.2 1 0 0 1 1 1 1 EF hand Wtap PF17098.5 KOO31219.1 - 0.022 14.7 10.4 0.053 13.5 10.4 1.7 1 0 0 1 1 1 0 WTAP/Mum2p family EF-hand_7 PF13499.6 KOO31219.1 - 0.023 15.2 0.0 0.076 13.5 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair DUF2913 PF11140.8 KOO31219.1 - 0.15 11.8 4.9 0.11 12.2 2.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2913) AP1AR PF15745.5 KOO31219.1 - 0.16 11.6 9.3 0.3 10.7 9.3 1.3 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein Atg14 PF10186.9 KOO31219.1 - 0.19 10.8 6.9 0.33 10.0 6.9 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fmp27_WPPW PF10359.9 KOO31219.1 - 0.2 10.4 3.0 0.18 10.7 1.5 1.5 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain AAA_16 PF13191.6 KOO31219.1 - 0.81 10.1 7.5 2.3 8.5 7.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain FlaC_arch PF05377.11 KOO31219.1 - 0.85 10.1 4.5 0.84 10.1 0.4 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.12 KOO31219.1 - 1.7 8.7 5.5 2.1 8.4 2.4 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cep57_MT_bd PF06657.13 KOO31219.1 - 2.3 8.8 13.6 3.4 8.2 0.8 3.7 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 AAA_23 PF13476.6 KOO31219.1 - 3 8.3 8.3 7.2 7.1 8.3 1.6 1 0 0 1 1 1 0 AAA domain IFT20 PF14931.6 KOO31219.1 - 4.5 7.5 17.7 0.32 11.2 2.9 2.9 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 DUF5320 PF17253.2 KOO31219.1 - 4.9 8.3 7.9 6.3 7.9 3.7 3.0 2 1 0 2 2 2 0 Family of unknown function (DUF5320) V_ATPase_I PF01496.19 KOO31219.1 - 5.5 4.8 12.2 0.92 7.4 3.1 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 KOO31219.1 - 5.7 6.4 9.9 12 5.3 9.9 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fzo_mitofusin PF04799.13 KOO31219.1 - 6.5 6.3 12.5 5.7 6.5 2.0 2.5 1 1 1 2 2 2 0 fzo-like conserved region FKBP_C PF00254.28 KOO31220.1 - 5.6e-33 113.1 0.0 6.9e-33 112.8 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CRT-like PF08627.10 KOO31221.1 - 5.5e-31 107.7 5.5 1.3e-29 103.2 5.5 2.1 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like Coatomer_b_Cpla PF14806.6 KOO31221.1 - 0.026 14.5 0.1 0.049 13.6 0.1 1.4 1 0 0 1 1 1 0 Coatomer beta subunit appendage platform EamA PF00892.20 KOO31221.1 - 3.8 7.7 23.5 0.74 10.0 0.1 3.6 4 0 0 4 4 4 0 EamA-like transporter family SAYSvFN PF10260.9 KOO31221.1 - 5.9 6.9 6.3 11 6.1 0.0 4.1 4 1 1 5 5 5 0 Uncharacterized conserved domain (SAYSvFN) VlpA_repeat PF04649.12 KOO31223.1 - 2.5 8.5 19.0 6.9 7.1 0.2 6.1 7 1 1 8 8 8 0 Mycoplasma hyorhinis VlpA repeat AAA_8 PF12780.7 KOO31224.1 - 3.4e-97 324.8 0.0 5.6e-97 324.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KOO31224.1 - 4.3e-84 281.0 0.0 1.3e-83 279.5 0.1 1.8 2 0 0 2 2 2 1 ATP-binding dynein motor region Dynein_C PF18199.1 KOO31224.1 - 3.1e-78 263.1 0.0 2.5e-77 260.1 0.0 2.6 2 1 0 2 2 2 1 Dynein heavy chain C-terminal domain MT PF12777.7 KOO31224.1 - 8.9e-57 192.7 9.1 1.3e-56 192.1 9.1 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KOO31224.1 - 4.2e-43 146.2 0.1 2.5e-37 127.6 0.0 2.8 3 0 0 3 3 2 2 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 KOO31224.1 - 3.2e-16 59.6 0.0 1.2e-11 44.7 0.0 2.6 2 0 0 2 2 2 2 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KOO31224.1 - 3.7e-13 49.5 0.0 1e-12 48.1 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain Sec34 PF04136.15 KOO31224.1 - 0.24 11.3 6.4 0.23 11.3 0.1 2.4 2 0 0 2 2 2 0 Sec34-like family TACC_C PF05010.14 KOO31224.1 - 2 8.2 10.4 0.73 9.6 2.7 2.4 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Spc7 PF08317.11 KOO31224.1 - 4.5 6.0 14.9 2.1 7.2 6.1 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Mod_r PF07200.13 KOO31224.1 - 6.6 6.8 12.1 0.42 10.7 4.9 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein LSM PF01423.22 KOO31226.1 - 9.4e-25 86.1 0.6 1e-24 86.0 0.6 1.0 1 0 0 1 1 1 1 LSM domain Methyltransf_23 PF13489.6 KOO31227.1 - 0.0012 18.8 0.0 0.0016 18.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain HEAT PF02985.22 KOO31228.1 - 0.0054 16.9 0.1 0.015 15.5 0.1 1.7 1 0 0 1 1 1 1 HEAT repeat NPR3 PF03666.13 KOO31229.1 - 0.037 12.8 0.0 2.2 7.0 0.0 2.9 2 2 2 4 4 4 0 Nitrogen Permease regulator of amino acid transport activity 3 Pyr_redox_2 PF07992.14 KOO31230.1 - 6.5e-05 22.3 0.0 0.0001 21.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO31230.1 - 0.00039 20.9 0.0 0.001 19.6 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO31230.1 - 0.00077 18.3 0.1 0.0013 17.6 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 KOO31230.1 - 0.0039 16.8 1.6 0.65 9.5 0.7 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOO31230.1 - 0.011 14.9 0.2 0.02 14.0 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 KOO31230.1 - 0.018 15.3 0.1 0.053 13.7 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOO31230.1 - 0.019 14.2 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO31230.1 - 0.03 13.6 0.2 0.063 12.5 0.2 1.5 1 0 0 1 1 1 0 FAD binding domain CDC48_2 PF02933.17 KOO31230.1 - 0.18 11.6 0.0 0.46 10.3 0.0 1.6 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 AlaDh_PNT_C PF01262.21 KOO31230.1 - 0.19 11.0 0.1 0.62 9.3 0.0 2.0 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain Dynamin_M PF01031.20 KOO31231.1 - 3.9e-29 101.8 0.2 1.3e-28 100.1 0.2 1.8 1 1 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 KOO31231.1 - 1.6e-15 57.5 0.0 3.6e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 KOO31231.1 - 3.4e-08 33.5 1.5 7.7e-08 32.4 0.4 2.2 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KOO31231.1 - 0.01 15.9 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase GBP PF02263.19 KOO31233.1 - 7e-63 212.3 0.0 8.9e-63 212.0 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 KOO31233.1 - 2.5e-13 50.1 0.0 3.3e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Arm PF00514.23 KOO31234.1 - 8.4e-92 298.8 69.3 2.3e-06 27.4 0.8 18.3 18 0 0 18 18 18 17 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO31234.1 - 7.3e-07 29.1 14.0 0.027 14.5 0.1 7.3 2 2 8 10 10 10 3 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO31234.1 - 1.1e-06 28.3 34.3 0.041 13.3 0.8 7.4 2 2 4 8 8 8 6 Armadillo-like HECT PF00632.25 KOO31234.1 - 0.049 13.1 0.0 0.084 12.3 0.0 1.3 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) Acyl-CoA_dh_N PF02771.16 KOO31234.1 - 0.051 14.2 38.4 67 4.2 0.4 12.9 6 5 8 14 14 14 0 Acyl-CoA dehydrogenase, N-terminal domain Reprolysin_5 PF13688.6 KOO31234.1 - 5.3 7.2 8.3 87 3.2 0.0 4.9 3 1 1 5 5 5 0 Metallo-peptidase family M12 Ribonuc_red_lgC PF02867.15 KOO31235.1 - 2.4e-184 613.8 0.0 2.9e-184 613.5 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 KOO31235.1 - 9.5e-24 83.2 0.0 2e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 KOO31235.1 - 4.8e-17 62.3 0.0 1.1e-16 61.1 0.0 1.7 1 0 0 1 1 1 1 ATP cone domain NDK PF00334.19 KOO31236.1 - 1.5e-06 28.3 0.0 0.024 14.6 0.0 2.2 2 0 0 2 2 2 2 Nucleoside diphosphate kinase EF-hand_1 PF00036.32 KOO31237.1 - 1e-26 90.4 6.3 1.4e-06 27.4 0.0 5.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO31237.1 - 6.4e-26 90.6 1.6 1.3e-10 41.6 0.3 4.6 4 2 0 4 4 4 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO31237.1 - 1.7e-21 75.8 13.5 1.5e-06 27.9 0.3 6.2 3 3 3 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO31237.1 - 5e-20 70.0 13.5 1.7e-06 27.2 0.0 6.0 5 2 2 7 7 7 4 EF hand EF-hand_6 PF13405.6 KOO31237.1 - 3.1e-18 64.1 6.1 0.00011 21.8 0.0 5.8 5 1 1 6 6 6 4 EF-hand domain EF-hand_4 PF12763.7 KOO31237.1 - 3.8e-09 36.4 2.9 0.033 14.1 0.0 5.0 2 1 3 5 5 5 3 Cytoskeletal-regulatory complex EF hand RIIa PF02197.17 KOO31237.1 - 2.6e-08 33.4 0.4 8.6e-08 31.7 0.4 1.9 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit SPARC_Ca_bdg PF10591.9 KOO31237.1 - 5.1e-06 26.8 0.1 0.046 14.0 0.1 2.5 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO31237.1 - 3.8e-05 24.5 0.1 1.6 9.7 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain DUF5580 PF17743.1 KOO31237.1 - 0.00024 19.8 0.0 0.91 8.0 0.0 3.0 1 1 2 3 3 3 2 Family of unknown function (DUF5580) EF-hand_10 PF14788.6 KOO31237.1 - 0.00041 20.2 0.9 2.5 8.0 0.0 4.6 5 1 1 6 6 6 2 EF hand NblA PF04485.12 KOO31237.1 - 0.045 14.2 0.1 1.6 9.2 0.0 2.7 2 0 0 2 2 2 0 Phycobilisome degradation protein nblA ADH_N PF08240.12 KOO31238.1 - 2e-31 108.1 1.1 4.1e-31 107.1 1.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOO31238.1 - 6.5e-21 74.7 1.2 1.6e-20 73.4 1.2 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase LRR_6 PF13516.6 KOO31238.1 - 3.7e-19 67.1 23.4 0.0001 22.0 0.1 9.2 9 0 0 9 9 9 5 Leucine Rich repeat ADH_zinc_N_2 PF13602.6 KOO31238.1 - 0.00016 22.7 0.6 0.00064 20.8 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 KOO31238.1 - 0.0011 18.4 0.0 0.0024 17.3 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KOO31238.1 - 0.012 15.0 3.3 0.026 13.8 3.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain LRR_8 PF13855.6 KOO31238.1 - 0.032 14.0 12.5 1.7 8.5 0.0 5.7 3 1 3 6 6 6 0 Leucine rich repeat LRR_4 PF12799.7 KOO31238.1 - 0.035 14.5 6.2 9.7 6.8 0.0 4.5 3 2 3 6 6 6 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO31238.1 - 0.083 13.5 4.3 1.9e+02 3.2 0.0 5.7 7 0 0 7 7 6 0 Leucine Rich Repeat FAD-SLDH PF12318.8 KOO31238.1 - 0.25 11.4 2.4 0.59 10.2 2.4 1.7 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase ATG16 PF08614.11 KOO31238.1 - 0.58 10.3 18.3 0.49 10.6 16.1 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4605 PF15378.6 KOO31238.1 - 0.81 9.6 2.2 2.8 7.9 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4605) V_ATPase_I PF01496.19 KOO31238.1 - 1.7 6.5 3.6 2.4 5.9 3.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 KOO31238.1 - 1.8 7.8 14.5 3 7.1 14.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GAS PF13851.6 KOO31238.1 - 3.1 7.1 10.8 4.9 6.4 10.8 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.15 KOO31238.1 - 8.4 5.9 9.4 14 5.2 9.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sulfotransfer_3 PF13469.6 KOO31239.1 - 4.5e-08 33.8 0.9 1.4e-07 32.1 0.0 2.3 3 0 0 3 3 3 1 Sulfotransferase family Glyco_transf_8 PF01501.20 KOO31239.1 - 8.7e-07 28.7 0.0 7.8e-06 25.6 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 CLN5 PF15014.6 KOO31239.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Ceroid-lipofuscinosis neuronal protein 5 Kelch_4 PF13418.6 KOO31240.1 - 1.1e-25 89.4 5.4 1.2e-05 25.2 0.1 6.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO31240.1 - 2.1e-21 75.5 4.0 0.00028 20.8 0.0 6.7 6 1 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KOO31240.1 - 2.8e-21 75.3 9.7 1e-05 25.7 0.1 5.5 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KOO31240.1 - 2.9e-17 61.9 2.9 8.4e-06 25.6 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 KOO31240.1 - 1.1e-13 51.0 4.1 0.00019 21.6 0.0 5.4 3 2 3 6 6 6 3 Kelch motif Kelch_1 PF01344.25 KOO31240.1 - 4.7e-13 48.5 0.3 4.3e-05 23.0 0.0 5.4 6 0 0 6 6 6 2 Kelch motif MAD PF05557.13 KOO31241.1 - 1.6e-08 33.5 1.0 1.6e-08 33.5 1.0 4.6 3 2 0 4 4 4 2 Mitotic checkpoint protein betaPIX_CC PF16523.5 KOO31241.1 - 0.47 10.3 10.9 9.7 6.1 0.1 3.4 3 0 0 3 3 3 0 betaPIX coiled coil ARL2_Bind_BART PF11527.8 KOO31242.1 - 5.9e-36 123.1 1.2 1e-35 122.3 1.2 1.4 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART UIM PF02809.20 KOO31242.1 - 0.48 10.5 27.4 0.051 13.5 3.4 4.6 4 0 0 4 4 4 0 Ubiquitin interaction motif Spermine_synth PF01564.17 KOO31243.1 - 0.0014 18.0 0.0 0.0031 16.9 0.0 1.5 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_25 PF13649.6 KOO31243.1 - 0.0052 17.5 0.0 0.025 15.3 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain XS PF03468.14 KOO31243.1 - 0.029 14.7 3.3 0.073 13.4 0.1 2.7 2 0 0 2 2 2 0 XS domain SET PF00856.28 KOO31244.1 - 3.2e-11 43.9 0.1 4.7e-10 40.1 0.1 2.1 1 1 0 1 1 1 1 SET domain Cu2_monoox_C PF03712.15 KOO31245.1 - 3.6e-07 29.8 0.0 0.0082 15.7 0.0 2.1 2 0 0 2 2 2 2 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Myb_DNA-binding PF00249.31 KOO31246.1 - 5.1e-05 23.4 0.0 7e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain AAA PF00004.29 KOO31247.1 - 1e-37 129.5 0.0 2.1e-37 128.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO31247.1 - 3.9e-12 45.8 0.6 9.4e-12 44.5 0.6 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KOO31247.1 - 1.9e-06 28.3 0.8 0.0017 18.7 0.1 2.8 2 1 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.13 KOO31247.1 - 0.0002 20.7 0.0 0.00051 19.4 0.0 1.6 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 KOO31247.1 - 0.00047 20.4 0.1 0.058 13.7 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 KOO31247.1 - 0.0014 18.7 0.0 0.0045 17.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KOO31247.1 - 0.0043 16.8 0.1 0.0081 15.9 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.12 KOO31247.1 - 0.0055 16.5 0.0 0.018 14.8 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 KOO31247.1 - 0.0078 15.6 0.0 0.018 14.4 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KOO31247.1 - 0.029 14.9 0.0 0.048 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO31247.1 - 0.093 12.9 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KOO31247.1 - 0.2 11.4 0.0 0.41 10.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Peptidase_C69 PF03577.15 KOO31248.1 - 2.9e-48 164.8 0.0 6.9e-48 163.5 0.0 1.5 1 1 0 1 1 1 1 Peptidase family C69 DUF3323 PF11796.8 KOO31248.1 - 0.13 12.1 0.7 0.28 11.0 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) UBA_4 PF14555.6 KOO31249.1 - 1.2e-11 44.2 0.2 2.6e-11 43.1 0.2 1.6 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.6 KOO31249.1 - 7.8e-11 42.0 0.0 1.3e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 KOO31249.1 - 0.00031 20.9 0.0 0.00055 20.1 0.0 1.4 1 0 0 1 1 1 1 UBX domain TAP_C PF03943.13 KOO31249.1 - 0.094 12.4 0.2 0.2 11.3 0.2 1.5 1 0 0 1 1 1 0 TAP C-terminal domain UIM PF02809.20 KOO31249.1 - 2 8.5 7.3 0.15 12.0 0.5 2.6 3 0 0 3 3 3 0 Ubiquitin interaction motif Abhydrolase_3 PF07859.13 KOO31250.1 - 6.4e-38 130.7 0.0 1e-37 130.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold KIAA1430 PF13879.6 KOO31250.1 - 2.3e-14 54.0 0.0 6.5e-14 52.5 0.0 1.8 1 1 0 1 1 1 1 KIAA1430 homologue Lipase_C PF18067.1 KOO31250.1 - 0.0019 18.7 0.0 0.0044 17.6 0.0 1.6 1 0 0 1 1 1 1 Lipase C-terminal domain COesterase PF00135.28 KOO31250.1 - 0.069 12.0 0.0 0.15 10.9 0.0 1.5 2 0 0 2 2 2 0 Carboxylesterase family Say1_Mug180 PF10340.9 KOO31250.1 - 0.23 10.3 0.1 1.3 7.8 0.1 1.9 1 1 0 1 1 1 0 Steryl acetyl hydrolase CAP_GLY PF01302.25 KOO31251.1 - 1.5e-09 37.7 0.0 2.8e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain IQ PF00612.27 KOO31251.1 - 0.32 10.9 21.5 2.6 8.1 0.2 5.3 5 0 0 5 5 5 0 IQ calmodulin-binding motif Ank_2 PF12796.7 KOO31252.1 - 3.5e-14 53.2 0.0 3.2e-07 30.9 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO31252.1 - 7.6e-13 48.3 0.0 0.0007 19.9 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KOO31252.1 - 1.5e-12 47.5 0.1 1.4e-06 28.4 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO31252.1 - 3.5e-12 46.6 0.0 3.9e-11 43.3 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO31252.1 - 6.8e-07 29.1 0.0 0.028 14.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat MHB PF16525.5 KOO31252.1 - 0.12 12.6 0.0 0.45 10.8 0.0 1.9 2 0 0 2 2 2 0 Haemophore, haem-binding EF-hand_6 PF13405.6 KOO31253.1 - 7.1e-27 91.0 2.9 8.1e-06 25.4 0.1 4.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO31253.1 - 3.4e-26 88.8 2.5 5.7e-06 25.5 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO31253.1 - 6.4e-23 81.0 4.0 1.3e-12 48.0 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO31253.1 - 2e-21 74.5 7.3 2e-05 23.9 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO31253.1 - 3.2e-12 46.1 7.9 0.00075 19.3 0.2 4.0 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_11 PF08976.11 KOO31253.1 - 0.0093 16.8 0.1 0.96 10.4 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain LPD7 PF18821.1 KOO31253.1 - 0.062 13.4 0.0 0.14 12.3 0.0 1.7 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 7 EF-hand_10 PF14788.6 KOO31253.1 - 0.15 12.0 0.6 8.5 6.3 0.0 2.9 3 0 0 3 3 3 0 EF hand EF-hand_4 PF12763.7 KOO31253.1 - 0.47 10.4 5.0 4.6 7.3 0.3 3.3 1 1 3 4 4 4 0 Cytoskeletal-regulatory complex EF hand IQ PF00612.27 KOO31254.1 - 2.4e-06 26.8 18.3 0.75 9.8 0.5 6.2 5 0 0 5 5 5 5 IQ calmodulin-binding motif tRNA-synt_2 PF00152.20 KOO31255.1 - 2.6e-77 260.0 0.0 3.3e-77 259.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOO31255.1 - 3e-11 43.1 0.0 7.7e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOO31255.1 - 1.7e-09 37.5 0.0 0.00013 21.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Ribosomal_60s PF00428.19 KOO31255.1 - 0.45 11.1 15.4 1.1 9.9 15.4 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Agenet PF05641.12 KOO31256.1 - 5.8e-05 23.5 0.4 0.002 18.6 0.0 2.7 2 0 0 2 2 2 1 Agenet domain Acetyltransf_1 PF00583.25 KOO31256.1 - 0.0079 16.4 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family SET PF00856.28 KOO31256.1 - 0.013 15.9 0.0 0.2 12.1 0.0 2.3 1 1 0 1 1 1 0 SET domain Acetyltransf_10 PF13673.7 KOO31256.1 - 0.063 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RVT_1 PF00078.27 KOO31257.1 - 0.15 11.5 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) LNS2 PF08235.13 KOO31258.1 - 6e-50 169.8 0.0 9.1e-50 169.2 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 KOO31258.1 - 2.7e-14 53.0 0.0 8.4e-14 51.4 0.0 1.7 2 0 0 2 2 2 1 lipin, N-terminal conserved region Ank_5 PF13857.6 KOO31258.1 - 3.5e-11 43.1 0.1 1.3e-10 41.3 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO31258.1 - 2.1e-08 34.7 0.2 1.1e-06 29.2 0.2 2.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO31258.1 - 1.3e-07 32.0 0.1 2.3e-06 28.1 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO31258.1 - 2.6e-07 30.8 4.1 2.7e-06 27.6 0.6 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 KOO31258.1 - 3e-07 30.2 0.0 0.0001 22.5 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat Apocytochr_F_C PF01333.19 KOO31258.1 - 0.039 14.0 0.0 3.2 7.8 0.0 2.4 2 0 0 2 2 2 0 Apocytochrome F, C-terminal DUF1930 PF09122.10 KOO31258.1 - 0.04 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1930) cobW PF02492.19 KOO31259.1 - 4.6e-37 127.3 0.1 5.8e-37 127.0 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 KOO31259.1 - 0.0011 19.3 0.0 0.002 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 KOO31259.1 - 0.0016 18.4 0.0 0.0029 17.6 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KOO31259.1 - 0.018 15.3 0.1 0.028 14.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOO31259.1 - 0.04 14.5 0.0 0.076 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO31259.1 - 0.069 13.3 0.1 0.26 11.4 0.1 1.9 2 0 0 2 2 2 0 AAA domain HC2 PF07382.11 KOO31260.1 - 0.0032 17.6 24.8 0.0043 17.2 24.8 1.1 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 RNA_pol_Rpc4 PF05132.14 KOO31260.1 - 2.8 8.3 5.4 3 8.2 5.4 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Agenet PF05641.12 KOO31261.1 - 0.005 17.3 0.2 0.56 10.7 0.0 2.6 2 0 0 2 2 2 2 Agenet domain CobW_C PF07683.14 KOO31262.1 - 0.0022 17.9 0.0 2.8 7.9 0.0 2.4 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain iPGM_N PF06415.13 KOO31263.1 - 5e-69 232.0 0.0 6.6e-69 231.6 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 KOO31263.1 - 1.5e-43 148.9 0.0 1.8e-43 148.7 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF563 PF04577.14 KOO31264.1 - 3.8e-21 76.2 0.0 5.3e-21 75.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF563) LRR_6 PF13516.6 KOO31265.1 - 1.5e-10 40.2 4.9 0.00091 19.1 0.1 5.4 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 KOO31265.1 - 0.0026 18.1 0.1 0.065 13.7 0.2 2.8 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) Raffinose_syn PF05691.12 KOO31266.1 - 0.088 10.6 0.0 0.17 9.6 0.0 1.4 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 zf_CCCH_4 PF18345.1 KOO31267.1 - 0.78 9.9 1.8 1.5 9.0 1.8 1.5 1 0 0 1 1 1 0 Zinc finger domain RGCC PF15151.6 KOO31267.1 - 0.79 9.9 3.6 1.4 9.1 0.3 2.6 2 0 0 2 2 2 0 Response gene to complement 32 protein family DUF4326 PF14216.6 KOO31268.1 - 1.8e-07 31.8 3.9 1.9e-07 31.7 1.8 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4326) CART PF06373.11 KOO31268.1 - 0.013 15.7 0.5 0.035 14.3 0.5 1.7 1 0 0 1 1 1 0 Cocaine and amphetamine regulated transcript protein (CART) HMG_box PF00505.19 KOO31270.1 - 7.4e-11 42.3 0.0 1.4e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box DUF2263 PF10021.9 KOO31270.1 - 2.3e-09 37.8 0.0 5.3e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) HMG_box_2 PF09011.10 KOO31270.1 - 1.4e-07 32.0 0.0 3.1e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 HMG-box domain hSac2 PF12456.8 KOO31270.1 - 0.00027 20.6 0.1 0.00089 19.0 0.0 1.8 2 0 0 2 2 2 1 Inositol phosphatase EF-hand_1 PF00036.32 KOO31270.1 - 0.0014 18.0 0.3 0.0032 16.9 0.3 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO31270.1 - 0.062 13.3 0.3 0.17 11.9 0.3 1.6 1 0 0 1 1 1 0 EF-hand domain Phosphoesterase PF04185.14 KOO31272.1 - 1.9e-43 149.1 1.6 1.2e-41 143.2 1.6 2.7 1 1 0 1 1 1 1 Phosphoesterase family DSBA PF01323.20 KOO31273.1 - 0.0019 18.0 0.0 0.0024 17.7 0.0 1.2 1 0 0 1 1 1 1 DSBA-like thioredoxin domain ThrE PF06738.12 KOO31275.1 - 0.024 14.0 0.1 0.038 13.4 0.1 1.2 1 0 0 1 1 1 0 Putative threonine/serine exporter DUF1995 PF09353.10 KOO31275.1 - 0.092 12.8 0.2 0.18 11.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1995) DUF5412 PF17428.2 KOO31276.1 - 0.093 12.6 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5412) Orbi_VP1 PF05788.12 KOO31276.1 - 0.15 9.6 0.0 0.18 9.3 0.0 1.0 1 0 0 1 1 1 0 Orbivirus RNA-dependent RNA polymerase (VP1) Pkinase PF00069.25 KOO31277.1 - 1.2e-47 162.6 0.0 1.6e-47 162.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31277.1 - 9.3e-30 103.8 0.0 1.5e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO31277.1 - 0.0032 16.8 0.0 0.0071 15.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO31277.1 - 0.13 12.2 0.2 0.13 12.2 0.2 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family MCLC PF05934.11 KOO31277.1 - 9.3 4.8 11.3 15 4.1 11.3 1.3 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) EF-hand_7 PF13499.6 KOO31278.1 - 9e-16 58.1 0.1 1.8e-09 37.9 0.0 1.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO31278.1 - 2.6e-13 48.5 0.2 8.5e-06 25.0 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO31278.1 - 1.8e-11 43.0 0.7 3.4e-05 23.1 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31278.1 - 7.6e-11 41.0 0.0 5.9e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO31278.1 - 1.3e-05 25.0 0.2 0.032 14.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair Dockerin_1 PF00404.18 KOO31278.1 - 0.22 11.8 2.3 2.3 8.5 0.1 2.2 1 1 1 2 2 2 0 Dockerin type I domain EF-hand_4 PF12763.7 KOO31278.1 - 0.24 11.4 0.3 4.8 7.2 0.0 2.0 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DcpS_C PF11969.8 KOO31279.1 - 7.5e-23 81.2 0.2 1.6e-22 80.1 0.2 1.6 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding AMP-binding PF00501.28 KOO31280.1 - 1.6e-94 316.9 0.1 1.9e-94 316.7 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOO31280.1 - 7.2e-13 49.3 3.2 1.3e-12 48.5 2.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain BT1 PF03092.16 KOO31281.1 - 1.2e-13 50.2 19.5 4.5e-06 25.2 1.7 3.3 3 0 0 3 3 3 3 BT1 family MFS_1 PF07690.16 KOO31281.1 - 5.3e-05 22.3 33.2 5.3e-05 22.3 33.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Herpes_UL49_5 PF05702.11 KOO31281.1 - 0.0047 17.0 0.7 0.0047 17.0 0.7 2.7 3 0 0 3 3 3 1 Herpesvirus UL49.5 envelope/tegument protein DUF5345 PF17280.2 KOO31281.1 - 8.9 6.4 8.5 4.5 7.3 0.0 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5345) CS PF04969.16 KOO31282.1 - 1.8e-12 48.1 0.0 2.7e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 CS domain Arm PF00514.23 KOO31283.1 - 4.7e-36 121.7 18.1 4.3e-07 29.7 0.0 6.8 8 0 0 8 8 8 6 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 KOO31283.1 - 2.6e-05 23.7 0.0 0.018 14.3 0.0 2.1 1 1 1 2 2 2 2 V-ATPase subunit H HEAT_EZ PF13513.6 KOO31283.1 - 5.1e-05 23.7 21.3 0.024 15.1 0.8 6.0 1 1 5 6 6 6 4 HEAT-like repeat HEAT_2 PF13646.6 KOO31283.1 - 0.00011 22.5 15.2 0.0077 16.6 4.2 4.3 2 2 2 4 4 4 2 HEAT repeats DUF5578 PF17741.1 KOO31283.1 - 0.00019 21.0 0.0 0.00045 19.7 0.0 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF5578) HEAT PF02985.22 KOO31283.1 - 0.00067 19.7 15.8 0.17 12.2 0.1 5.5 6 0 0 6 6 6 2 HEAT repeat RICTOR_N PF14664.6 KOO31283.1 - 0.017 14.1 0.0 2.7 6.9 0.0 2.4 1 1 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term TetR_C_16 PF17920.1 KOO31283.1 - 0.088 13.0 2.0 1.4 9.2 0.0 2.8 1 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Cnd1 PF12717.7 KOO31283.1 - 0.17 11.9 0.0 6 6.9 0.0 2.5 1 1 2 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Glyco_hydro_47 PF01532.20 KOO31284.1 - 2.2e-114 382.9 0.0 4e-114 382.0 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Pro_isomerase PF00160.21 KOO31285.1 - 4.1e-20 72.6 0.2 4.9e-20 72.4 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PRK PF00485.18 KOO31286.1 - 7.4e-60 202.1 0.0 1e-59 201.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_23 PF13476.6 KOO31286.1 - 0.033 14.7 0.0 0.068 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOO31286.1 - 0.035 14.7 0.0 0.16 12.6 0.0 2.2 2 1 0 2 2 2 0 AAA domain G-alpha PF00503.20 KOO31286.1 - 0.055 12.6 0.0 0.069 12.3 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit RNA_pol_Rpb8 PF03870.15 KOO31287.1 - 4.6e-42 143.5 0.1 5.2e-42 143.3 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 KOO31287.1 - 0.00026 21.0 0.0 0.0036 17.3 0.0 2.0 2 0 0 2 2 2 1 DNA-directed RNA polymerase, subunit G Arm PF00514.23 KOO31288.1 - 1.3e-40 136.2 24.2 8.4e-08 32.0 0.2 7.6 6 1 1 7 7 7 7 Armadillo/beta-catenin-like repeat U-box PF04564.15 KOO31288.1 - 6.7e-16 58.2 0.1 1.1e-15 57.6 0.1 1.3 1 0 0 1 1 1 1 U-box domain Arm_2 PF04826.13 KOO31288.1 - 5.9e-11 42.3 0.0 0.015 14.8 0.0 4.1 1 1 3 4 4 4 4 Armadillo-like zf-Nse PF11789.8 KOO31288.1 - 0.00081 19.2 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO31288.1 - 0.038 14.1 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Arm PF00514.23 KOO31290.1 - 9.5e-12 44.5 4.8 1.8e-05 24.6 0.0 4.0 3 1 1 4 4 4 3 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO31290.1 - 0.005 16.8 0.0 0.0071 16.3 0.0 1.3 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain MotA_ExbB PF01618.16 KOO31290.1 - 0.082 12.7 0.5 0.7 9.6 0.0 2.0 1 1 1 2 2 2 0 MotA/TolQ/ExbB proton channel family MORN PF02493.20 KOO31291.1 - 1.1e-29 100.5 31.4 1.5e-07 30.9 3.3 5.3 5 0 0 5 5 5 5 MORN repeat CH_2 PF06294.11 KOO31292.1 - 0.78 9.9 9.7 0.71 10.0 0.3 4.0 4 0 0 4 4 4 0 CH-like domain in sperm protein EF-hand_8 PF13833.6 KOO31292.1 - 1.9 8.4 10.5 36 4.3 0.1 5.7 5 0 0 5 5 5 0 EF-hand domain pair DUF3188 PF11384.8 KOO31293.1 - 0.064 13.0 0.3 0.11 12.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) Phage_HK97_TLTM PF06120.11 KOO31293.1 - 0.88 8.7 4.1 1.2 8.2 4.1 1.1 1 0 0 1 1 1 0 Tail length tape measure protein MFS_1 PF07690.16 KOO31296.1 - 3e-09 36.3 16.9 3e-09 36.3 16.9 3.2 2 2 0 2 2 2 1 Major Facilitator Superfamily SPX PF03105.19 KOO31296.1 - 0.023 14.6 0.5 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 SPX domain TPR_12 PF13424.6 KOO31297.1 - 1.5e-10 41.2 16.9 2.3e-07 31.0 12.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO31297.1 - 1.3e-06 28.0 14.7 0.0038 17.1 0.4 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO31297.1 - 2.9e-06 26.8 7.5 0.19 11.6 0.7 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31297.1 - 6.3e-06 26.0 4.9 0.1 12.8 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO31297.1 - 0.00052 19.9 21.7 0.11 12.7 2.9 4.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO31297.1 - 0.0022 17.8 25.1 0.083 12.8 3.2 4.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO31297.1 - 0.012 16.0 7.1 0.97 10.0 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Prefoldin PF02996.17 KOO31297.1 - 0.053 13.4 0.3 0.9 9.5 0.0 2.6 2 1 0 2 2 2 0 Prefoldin subunit TPR_14 PF13428.6 KOO31297.1 - 3.6 8.7 30.9 1.9 9.5 0.4 5.0 2 2 3 5 5 5 0 Tetratricopeptide repeat Arginosuc_synth PF00764.19 KOO31298.1 - 1.5e-72 245.1 0.0 1.8e-72 244.8 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 KOO31298.1 - 0.00065 19.3 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 KOO31298.1 - 0.001 18.8 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase Cupin_2 PF07883.11 KOO31299.1 - 0.0023 17.6 0.3 0.0058 16.3 0.0 1.7 1 1 1 2 2 2 1 Cupin domain AraC_binding_2 PF14525.6 KOO31299.1 - 0.0062 16.2 0.0 0.0067 16.1 0.0 1.3 1 1 0 1 1 1 1 AraC-binding-like domain PEN-2 PF10251.9 KOO31300.1 - 2.5e-17 63.1 0.1 3.3e-17 62.7 0.1 1.1 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase Myc_target_1 PF15179.6 KOO31301.1 - 0.044 13.7 2.3 0.063 13.2 2.3 1.2 1 0 0 1 1 1 0 Myc target protein 1 V_ATPase_I PF01496.19 KOO31301.1 - 0.4 8.6 3.3 0.44 8.4 3.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 KOO31301.1 - 0.51 9.9 8.5 0.7 9.4 8.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 KOO31301.1 - 0.94 8.5 13.1 1.2 8.1 13.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3584 PF12128.8 KOO31301.1 - 1.3 6.4 17.2 1.7 6.1 17.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Sec34 PF04136.15 KOO31301.1 - 1.6 8.6 7.3 0.23 11.3 1.5 2.0 1 1 1 2 2 2 0 Sec34-like family PV-1 PF06637.11 KOO31301.1 - 1.7 7.4 13.2 2.2 7.0 13.2 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) Spc7 PF08317.11 KOO31301.1 - 2.8 6.8 17.8 3.3 6.5 17.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Methyltransf_21 PF05050.12 KOO31303.1 - 0.00075 19.6 0.0 0.0014 18.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase FkbM domain START PF01852.19 KOO31304.1 - 0.0019 17.7 0.3 0.0024 17.3 0.3 1.2 1 0 0 1 1 1 1 START domain NAD_binding_1 PF00175.21 KOO31305.1 - 7.5e-26 90.9 0.0 2e-25 89.5 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOO31305.1 - 4.4e-05 23.6 0.0 0.00095 19.3 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Glyco_hydro_38C PF07748.13 KOO31305.1 - 0.0021 18.2 0.0 0.37 10.8 0.0 2.4 2 1 0 2 2 2 2 Glycosyl hydrolases family 38 C-terminal domain CAP_GLY PF01302.25 KOO31306.1 - 1.4e-14 53.9 0.1 2.3e-14 53.2 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain Isochorismatase PF00857.20 KOO31306.1 - 5.2e-14 52.8 0.0 1.1e-05 25.7 0.0 2.2 2 0 0 2 2 2 2 Isochorismatase family WW PF00397.26 KOO31307.1 - 0.00026 21.0 0.1 0.00048 20.2 0.1 1.5 1 0 0 1 1 1 1 WW domain YtxH PF12732.7 KOO31307.1 - 0.077 13.5 0.1 0.077 13.5 0.1 4.5 3 1 0 3 3 3 0 YtxH-like protein BLOC1_2 PF10046.9 KOO31307.1 - 0.095 13.0 11.2 0.25 11.6 2.7 3.5 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ApoO PF09769.9 KOO31307.1 - 0.44 10.5 2.3 6.1 6.8 0.0 3.0 3 0 0 3 3 3 0 Apolipoprotein O GAS PF13851.6 KOO31307.1 - 1.6 8.1 29.6 0.34 10.2 8.5 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding zf-C3HC4_2 PF13923.6 KOO31309.1 - 0.21 11.5 3.2 14 5.6 0.0 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) HAD_2 PF13419.6 KOO31310.1 - 8.5e-18 65.1 0.0 4.8e-17 62.6 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO31310.1 - 1.5e-10 41.7 0.0 3.3e-10 40.6 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO31310.1 - 0.013 15.6 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like NIF PF03031.18 KOO31310.1 - 0.043 13.6 0.0 0.069 12.9 0.0 1.3 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase BROMI PF14961.6 KOO31312.1 - 0.031 11.7 0.4 0.032 11.7 0.4 1.0 1 0 0 1 1 1 0 Broad-minded protein Arena_nucleocap PF00843.17 KOO31312.1 - 0.047 12.6 0.7 0.054 12.4 0.7 1.1 1 0 0 1 1 1 0 Arenavirus nucleocapsid N-terminal domain Thymidylat_synt PF00303.19 KOO31314.1 - 5.1e-98 327.5 0.0 7e-98 327.0 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.19 KOO31314.1 - 2.6e-31 108.5 0.0 5.1e-29 101.1 0.0 2.3 2 0 0 2 2 2 2 Dihydrofolate reductase 40S_S4_C PF16121.5 KOO31314.1 - 0.029 14.0 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 40S ribosomal protein S4 C-terminus SKI PF01202.22 KOO31315.1 - 4.4e-07 30.1 0.0 6.5e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase DUF3506 PF12014.8 KOO31315.1 - 1.7e-06 28.1 0.0 3.8e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3506) AAA_33 PF13671.6 KOO31315.1 - 9.1e-06 25.9 0.0 1.6e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO31315.1 - 0.016 15.6 0.0 0.042 14.2 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 KOO31315.1 - 0.058 13.9 0.1 0.29 11.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOO31315.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KOO31315.1 - 0.18 12.2 0.0 0.52 10.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 KOO31316.1 - 2.4e-46 158.3 0.0 2.9e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31316.1 - 4e-20 72.2 0.0 5.5e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO31316.1 - 0.0031 17.5 0.0 0.0058 16.6 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Aldo_ket_red PF00248.21 KOO31317.1 - 9.1e-05 21.8 0.0 0.00017 20.9 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Fasciclin PF02469.22 KOO31318.1 - 1.5e-35 122.2 0.0 2e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Fasciclin domain RPS31 PF17067.5 KOO31318.1 - 2.2e-05 24.5 0.2 5.8e-05 23.2 0.2 1.7 1 0 0 1 1 1 1 Ribosomal protein S31e RVT_2 PF07727.14 KOO31319.1 - 1.5e-23 83.7 0.0 2.3e-23 83.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EF-hand_6 PF13405.6 KOO31320.1 - 4.9e-16 57.2 6.6 0.00017 21.2 0.2 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO31320.1 - 9.2e-16 56.2 3.3 3.2e-05 23.2 0.2 3.7 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO31320.1 - 6.9e-13 48.8 3.7 1.8e-06 28.3 1.4 4.4 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO31320.1 - 1e-10 40.6 8.2 0.00041 19.7 0.5 3.7 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO31320.1 - 6.1e-08 32.4 2.1 0.11 12.3 0.1 3.7 2 1 1 3 3 3 3 EF-hand domain pair BLOC1S3 PF15753.5 KOO31320.1 - 0.0077 16.4 9.7 0.029 14.5 0.8 4.0 3 0 0 3 3 3 2 Biogenesis of lysosome-related organelles complex 1 subunit 3 EF-hand_11 PF08976.11 KOO31320.1 - 0.022 15.6 0.0 0.21 12.5 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain HALZ PF02183.18 KOO31320.1 - 1.8 8.9 0.0 1.8 8.9 0.0 7.2 9 0 0 9 9 9 0 Homeobox associated leucine zipper IQ PF00612.27 KOO31321.1 - 0.0048 16.6 0.1 0.015 15.0 0.1 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif Neur_chan_memb PF02932.16 KOO31322.1 - 0.00032 20.8 1.7 0.00032 20.8 1.7 2.2 2 1 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DEAD PF00270.29 KOO31324.1 - 2.1e-05 24.4 0.0 0.00019 21.3 0.0 2.6 3 1 0 3 3 3 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOO31324.1 - 0.00094 19.5 0.4 0.1 12.9 0.0 4.1 3 1 1 4 4 4 1 AAA domain ResIII PF04851.15 KOO31324.1 - 0.0041 17.2 0.0 0.21 11.6 0.0 2.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Rpr2 PF04032.16 KOO31324.1 - 0.22 11.8 0.5 1.6 9.1 0.0 2.8 4 0 0 4 4 4 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain UvrD-helicase PF00580.21 KOO31324.1 - 0.47 9.9 0.0 0.47 9.9 0.0 3.2 4 0 0 4 4 4 0 UvrD/REP helicase N-terminal domain SesA PF17107.5 KOO31324.1 - 0.54 10.5 12.5 2.2 8.5 0.1 5.3 5 0 0 5 5 5 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Thioredoxin PF00085.20 KOO31325.1 - 6.7e-27 93.5 0.0 1.1e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin PUB PF09409.10 KOO31325.1 - 4.2e-20 71.5 0.0 6e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 PUB domain Thioredoxin_2 PF13098.6 KOO31325.1 - 0.0002 21.8 0.0 0.0023 18.3 0.0 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 KOO31325.1 - 0.00024 20.6 0.0 0.0003 20.2 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 KOO31325.1 - 0.00031 21.0 0.0 0.00055 20.2 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 KOO31325.1 - 0.00057 19.7 0.0 0.00091 19.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 KOO31325.1 - 0.0015 18.4 0.0 0.0031 17.4 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family TraF PF13728.6 KOO31325.1 - 0.0057 16.5 0.0 0.0096 15.8 0.0 1.4 1 0 0 1 1 1 1 F plasmid transfer operon protein Redoxin PF08534.10 KOO31325.1 - 0.014 15.1 0.0 0.14 11.8 0.0 2.2 2 0 0 2 2 2 0 Redoxin Thioredoxin_7 PF13899.6 KOO31325.1 - 0.014 15.5 0.1 0.036 14.3 0.1 1.8 1 1 0 1 1 1 0 Thioredoxin-like 2OG-FeII_Oxy_3 PF13640.6 KOO31326.1 - 4.3e-15 56.4 0.0 1.4e-14 54.7 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily CS PF04969.16 KOO31326.1 - 8e-06 26.8 0.0 1.6e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 CS domain 2OG-FeII_Oxy_4 PF13661.6 KOO31326.1 - 2.2e-05 25.0 0.0 4e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3886 PF13025.6 KOO31326.1 - 2.1 8.6 6.7 2.8 8.2 5.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) Fez1 PF06818.15 KOO31328.1 - 0.0043 17.5 15.5 0.0058 17.1 15.5 1.2 1 0 0 1 1 1 1 Fez1 Muted PF14942.6 KOO31328.1 - 0.069 13.5 11.0 0.048 14.0 8.8 1.8 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Prok-E2_C PF14459.6 KOO31328.1 - 0.092 12.9 1.2 0.16 12.1 1.2 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family C RasGAP_C PF03836.15 KOO31328.1 - 0.33 11.1 6.1 0.47 10.6 6.0 1.5 1 1 0 1 1 1 0 RasGAP C-terminus Prominin PF05478.11 KOO31328.1 - 0.49 8.3 6.0 0.54 8.1 5.1 1.5 1 1 0 1 1 1 0 Prominin FLYWCH_u PF16662.5 KOO31328.1 - 0.53 10.4 3.5 0.48 10.5 1.3 2.1 1 1 1 2 2 2 0 FLYWCH-type zinc finger-containing protein 1 Adeno_PIX PF03955.14 KOO31328.1 - 2.4 8.3 6.1 0.52 10.5 1.0 2.2 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) TFIIA PF03153.13 KOO31328.1 - 5.6 6.9 13.1 6.2 6.7 13.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 KOO31328.1 - 6 4.7 7.6 7.2 4.4 7.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 KOO31328.1 - 7.2 6.1 14.7 9.9 5.6 14.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.11 KOO31328.1 - 7.4 5.3 20.0 0.31 9.9 4.4 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Fringe PF02434.16 KOO31329.1 - 7.7e-10 38.6 0.2 4.5e-09 36.1 0.2 2.1 1 1 0 1 1 1 1 Fringe-like Sulfotransfer_3 PF13469.6 KOO31329.1 - 7.7e-09 36.3 13.1 0.0039 17.6 0.0 4.7 2 2 2 4 4 4 3 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO31329.1 - 4e-08 33.1 0.1 2.5e-07 30.5 0.1 2.2 1 1 0 1 1 1 1 Sulfotransferase domain LisH_2 PF16045.5 KOO31329.1 - 6.3e-05 21.9 0.4 0.00012 21.0 0.4 1.5 1 0 0 1 1 1 1 LisH Sulfotransfer_2 PF03567.14 KOO31329.1 - 0.0013 18.7 0.1 0.0037 17.2 0.1 1.8 1 0 0 1 1 1 1 Sulfotransferase family FOP_dimer PF09398.10 KOO31329.1 - 0.0014 18.9 0.0 0.0042 17.3 0.0 1.8 1 0 0 1 1 1 1 FOP N terminal dimerisation domain DUF4810 PF16068.5 KOO31329.1 - 0.089 13.3 0.6 0.37 11.4 0.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4810) LisH PF08513.11 KOO31329.1 - 0.12 12.3 0.0 1.1 9.3 0.0 2.5 3 0 0 3 3 3 0 LisH CRAL_TRIO PF00650.20 KOO31331.1 - 4.4e-10 39.5 0.0 8.3e-09 35.4 0.0 2.1 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KOO31331.1 - 0.00087 19.5 0.0 0.0014 18.7 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Proteasome PF00227.26 KOO31334.1 - 1.1e-45 155.5 0.0 1.3e-45 155.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOO31334.1 - 4.6e-14 51.8 0.0 8.8e-14 50.9 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature HEAT_EZ PF13513.6 KOO31335.1 - 0.00012 22.5 24.0 0.95 10.0 0.0 8.5 8 2 2 10 10 10 4 HEAT-like repeat MIP PF00230.20 KOO31336.1 - 3.8e-06 26.8 8.8 2.1e-05 24.3 8.7 2.0 1 1 0 1 1 1 1 Major intrinsic protein DUF4577 PF15145.6 KOO31336.1 - 0.08 13.0 0.2 0.23 11.5 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) LRR_6 PF13516.6 KOO31337.1 - 0.14 12.3 1.2 0.26 11.4 0.7 1.8 2 0 0 2 2 2 0 Leucine Rich repeat Proteasome PF00227.26 KOO31338.1 - 0.0017 17.9 0.1 0.0023 17.5 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Ribosomal_L12_N PF16320.5 KOO31338.1 - 0.16 11.7 2.5 0.7 9.6 2.5 2.0 1 1 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain Spc7 PF08317.11 KOO31339.1 - 0.22 10.4 9.1 0.27 10.1 9.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein adh_short PF00106.25 KOO31341.1 - 3.9e-18 65.6 0.3 5.6e-18 65.1 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO31341.1 - 3.4e-16 59.5 0.4 3.5e-16 59.5 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 KOO31341.1 - 0.00016 21.2 0.0 0.00019 20.9 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Cpn60_TCP1 PF00118.24 KOO31342.1 - 5.7e-146 487.0 11.0 6.5e-146 486.8 11.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dak2 PF02734.17 KOO31342.1 - 0.018 14.9 1.4 0.28 11.1 0.2 2.6 2 0 0 2 2 2 0 DAK2 domain YbaB_DNA_bd PF02575.16 KOO31342.1 - 0.53 10.5 5.1 0.93 9.8 0.3 3.1 2 1 0 2 2 2 0 YbaB/EbfC DNA-binding family Arm PF00514.23 KOO31344.1 - 0.00076 19.4 0.2 2.1 8.5 0.0 3.4 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat Biotin_lipoyl PF00364.22 KOO31345.1 - 0.12 12.2 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Biotin-requiring enzyme Ank_5 PF13857.6 KOO31346.1 - 1.2e-13 51.0 0.3 1.1e-05 25.5 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO31346.1 - 2.6e-13 50.4 0.0 7.3e-10 39.3 0.0 2.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Hydrolase_like PF13242.6 KOO31346.1 - 9e-12 44.9 0.4 2.8e-11 43.3 0.1 2.0 2 0 0 2 2 2 1 HAD-hyrolase-like Ank_4 PF13637.6 KOO31346.1 - 1.9e-11 44.2 0.2 9.9e-05 22.8 0.0 4.2 2 1 3 5 5 5 3 Ankyrin repeats (many copies) HAD_2 PF13419.6 KOO31346.1 - 1.9e-11 44.3 0.0 2.7e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Ank_3 PF13606.6 KOO31346.1 - 2.8e-11 42.6 0.0 0.0056 17.1 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Hydrolase PF00702.26 KOO31346.1 - 1.4e-09 38.6 0.5 4.7e-09 36.8 0.0 1.9 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ank PF00023.30 KOO31346.1 - 4.5e-09 36.4 0.9 0.0011 19.3 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat HAD PF12710.7 KOO31346.1 - 0.0001 22.8 0.0 0.00023 21.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KOO31346.1 - 0.027 14.6 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pyr_redox_2 PF07992.14 KOO31347.1 - 3e-57 194.1 6.6 4e-57 193.7 6.6 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOO31347.1 - 8e-32 109.8 2.1 1.7e-31 108.7 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOO31347.1 - 9e-13 48.6 0.0 9e-13 48.6 0.0 2.9 4 0 0 4 4 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO31347.1 - 8.9e-07 28.3 10.1 0.0088 15.2 0.1 2.9 3 0 0 3 3 3 2 FAD binding domain K_oxygenase PF13434.6 KOO31347.1 - 0.00028 20.1 0.3 0.00089 18.5 0.0 1.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 KOO31347.1 - 0.001 18.2 15.3 0.0048 16.0 10.3 2.6 2 1 0 2 2 2 1 Glucose inhibited division protein A 3HCDH_N PF02737.18 KOO31347.1 - 0.0019 18.1 1.4 1.4 8.7 0.0 2.5 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 KOO31347.1 - 0.015 14.6 4.9 0.022 14.1 4.9 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 KOO31347.1 - 0.037 13.6 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Thi4 PF01946.17 KOO31347.1 - 0.066 12.4 2.3 0.079 12.2 0.8 1.9 2 0 0 2 2 2 0 Thi4 family Pyr_redox_3 PF13738.6 KOO31347.1 - 6.3 5.9 6.8 13 4.9 0.1 2.5 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Roc PF08477.13 KOO31348.1 - 3.7e-06 27.1 0.0 6.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RPGR1_C PF18111.1 KOO31348.1 - 4.7e-06 26.6 0.0 1.2e-05 25.3 0.0 1.7 2 0 0 2 2 2 1 Retinitis pigmentosa G-protein regulator interacting C-terminal DUF2505 PF10698.9 KOO31349.1 - 4.6e-07 30.1 0.0 1.2e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) Proteasome PF00227.26 KOO31350.1 - 4.8e-27 94.7 0.1 5.6e-27 94.5 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit CS PF04969.16 KOO31351.1 - 4.7e-11 43.6 0.0 0.00094 20.2 0.0 3.3 3 0 0 3 3 3 3 CS domain BCAS2 PF05700.11 KOO31352.1 - 1.7e-62 210.8 11.5 2.1e-62 210.5 11.5 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) HAUS-augmin3 PF14932.6 KOO31352.1 - 0.036 13.7 5.8 0.029 14.0 4.6 1.4 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4995 PF16386.5 KOO31352.1 - 0.081 12.9 1.5 0.21 11.6 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function NYD-SP28 PF14772.6 KOO31352.1 - 3 7.9 10.5 0.15 12.1 0.5 2.2 1 1 1 2 2 2 0 Sperm tail Pkinase_Tyr PF07714.17 KOO31354.1 - 5.9e-24 84.7 0.0 7.3e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO31354.1 - 3.8e-22 78.9 0.0 5.1e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO31354.1 - 0.0013 18.8 0.3 0.0024 17.8 0.1 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO31354.1 - 0.12 11.1 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase RabGAP-TBC PF00566.18 KOO31355.1 - 1.3e-41 142.6 0.4 4e-31 108.3 0.0 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Copine PF07002.16 KOO31355.1 - 0.00048 19.6 0.0 0.0016 17.9 0.0 1.8 2 0 0 2 2 2 1 Copine Chloroa_b-bind PF00504.21 KOO31356.1 - 1.9e-36 126.0 0.2 2.4e-36 125.7 0.2 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Nop14 PF04147.12 KOO31357.1 - 0.16 10.1 0.0 0.19 9.9 0.0 1.0 1 0 0 1 1 1 0 Nop14-like family MBOAT_2 PF13813.6 KOO31358.1 - 1e-09 38.5 1.1 1e-09 38.5 1.1 2.0 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family MBOAT PF03062.19 KOO31358.1 - 1.9e-05 24.2 1.6 2.9e-05 23.6 1.6 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF4491 PF14898.6 KOO31358.1 - 0.52 10.8 6.1 0.63 10.5 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4491) LRR_4 PF12799.7 KOO31359.1 - 3e-15 56.1 26.6 0.0003 21.1 0.4 10.8 10 0 0 10 10 10 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO31359.1 - 7.8e-10 38.4 14.4 2.2e-07 30.5 2.1 9.2 8 3 2 11 11 11 3 Leucine rich repeat LRR_6 PF13516.6 KOO31359.1 - 1.2e-09 37.5 43.2 0.19 11.9 0.3 15.1 19 0 0 19 19 19 5 Leucine Rich repeat FKBP_C PF00254.28 KOO31359.1 - 4.3e-07 30.2 0.1 9.4e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NACHT PF05729.12 KOO31359.1 - 0.028 14.3 0.1 0.069 13.1 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 KOO31359.1 - 0.12 12.7 0.0 0.34 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain LRR_1 PF00560.33 KOO31359.1 - 0.46 11.2 20.4 41 5.3 0.5 9.9 10 1 0 10 10 10 0 Leucine Rich Repeat LRR_9 PF14580.6 KOO31359.1 - 1.4 8.4 5.1 0.76 9.3 0.9 2.8 3 0 0 3 3 3 0 Leucine-rich repeat Chromo PF00385.24 KOO31361.1 - 2.2e-09 37.1 0.0 4.4e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain LysM PF01476.20 KOO31361.1 - 2.4e-06 27.5 0.0 0.002 18.2 0.0 2.8 3 0 0 3 3 3 2 LysM domain Acetyltransf_10 PF13673.7 KOO31361.1 - 0.0014 18.6 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO31361.1 - 0.038 14.2 0.1 0.087 13.1 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family zf-MIZ PF02891.20 KOO31362.1 - 2.4e-19 68.8 1.4 5.3e-19 67.7 1.4 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KOO31362.1 - 5.1e-05 23.0 0.1 0.00016 21.4 0.1 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit TetR_C_36 PF18598.1 KOO31363.1 - 0.017 15.1 0.0 0.29 11.1 0.0 2.3 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Tctex-1 PF03645.13 KOO31364.1 - 6e-22 77.8 0.0 6.4e-22 77.7 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family HRDC PF00570.23 KOO31365.1 - 0.026 14.5 7.3 0.27 11.3 0.0 3.4 3 0 0 3 3 3 0 HRDC domain BSD PF03909.17 KOO31365.1 - 0.12 12.3 0.1 19 5.3 0.0 2.6 2 0 0 2 2 2 0 BSD domain DUF3135 PF11333.8 KOO31365.1 - 4.6 7.6 8.3 4.1 7.7 0.5 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3135) RRN9 PF10680.9 KOO31365.1 - 5.3 7.4 5.6 2.1 8.7 0.1 2.8 3 1 0 3 3 3 0 RNA polymerase I specific transcription initiation factor SGL PF08450.12 KOO31366.1 - 4.5e-58 196.7 0.0 5.5e-58 196.4 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 KOO31366.1 - 0.00025 20.9 0.0 0.99 9.8 0.0 3.0 2 0 0 2 2 2 2 Two component regulator propeller EF-hand_1 PF00036.32 KOO31367.1 - 2.4e-10 39.2 0.2 0.0011 18.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31367.1 - 8.6e-10 37.8 0.1 0.002 17.9 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO31367.1 - 1.3e-09 37.1 0.5 0.00046 19.6 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO31367.1 - 2.7e-08 34.1 0.2 0.0044 17.4 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO31367.1 - 0.00021 21.1 0.0 0.66 9.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair Kelch_5 PF13854.6 KOO31368.1 - 7.7e-36 121.5 3.5 5.5e-06 26.2 0.1 9.7 9 0 0 9 9 9 8 Kelch motif Kelch_4 PF13418.6 KOO31368.1 - 7.5e-33 112.3 5.9 9e-09 35.2 0.0 9.4 10 0 0 10 10 10 6 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO31368.1 - 2.3e-32 110.2 3.7 0.00021 21.4 0.0 9.6 8 2 2 10 10 9 6 Kelch motif Kelch_1 PF01344.25 KOO31368.1 - 6.4e-29 99.3 14.1 0.0014 18.2 0.0 10.3 10 1 0 10 10 10 7 Kelch motif Kelch_3 PF13415.6 KOO31368.1 - 4.4e-28 97.0 15.0 3.8e-05 23.9 0.0 9.5 10 0 0 10 10 10 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KOO31368.1 - 6.2e-28 95.7 9.0 0.00099 19.0 0.1 9.4 10 0 0 10 10 9 7 Kelch motif Pkinase PF00069.25 KOO31368.1 - 8.2e-20 71.3 0.0 5.1e-19 68.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 KOO31368.1 - 3.4e-10 40.2 0.1 6.8e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO31368.1 - 2.7e-08 33.8 0.1 5.4e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_Tyr PF07714.17 KOO31368.1 - 2e-07 30.6 0.0 7.7e-07 28.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO31368.1 - 5.4e-06 25.9 0.0 2.7e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO31368.1 - 0.00016 21.1 0.2 0.00033 20.1 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOO31368.1 - 0.0076 15.9 0.1 0.014 15.0 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Acyl-CoA_dh_1 PF00441.24 KOO31368.1 - 0.65 10.2 8.6 1.9 8.6 3.4 2.7 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain Glyco_hydro_30 PF02055.16 KOO31369.1 - 1.9e-74 250.7 0.1 2.4e-74 250.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 KOO31369.1 - 1.3e-11 44.6 0.1 3.9e-11 43.0 0.1 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Ricin_B_lectin PF00652.22 KOO31369.1 - 5.8e-10 39.5 0.2 1.2e-08 35.2 0.2 2.4 1 1 1 2 2 2 1 Ricin-type beta-trefoil lectin domain Glyco_hydro_59 PF02057.15 KOO31369.1 - 2e-07 30.5 0.1 3.2e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 RicinB_lectin_2 PF14200.6 KOO31369.1 - 1.7e-05 25.5 0.3 0.00013 22.6 0.1 2.6 2 1 1 3 3 3 2 Ricin-type beta-trefoil lectin domain-like rve PF00665.26 KOO31370.1 - 0.013 15.7 0.0 0.032 14.4 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain EF-hand_1 PF00036.32 KOO31371.1 - 6.5e-25 84.8 0.4 3.9e-06 26.0 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO31371.1 - 6.2e-22 76.1 2.6 1.7e-06 27.2 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO31371.1 - 2.8e-21 73.6 2.7 0.00014 21.5 0.0 4.8 4 1 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO31371.1 - 9e-20 70.9 0.8 7.4e-09 35.9 0.1 2.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO31371.1 - 9.3e-13 47.8 2.4 0.0033 17.2 0.1 4.4 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO31371.1 - 5.3e-05 23.5 0.6 0.098 13.0 0.0 2.6 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO31371.1 - 0.071 13.0 0.4 3.6 7.5 0.1 2.8 2 1 1 3 3 3 0 Caleosin related protein EF-hand_4 PF12763.7 KOO31371.1 - 0.13 12.2 2.7 16 5.5 0.0 3.3 2 2 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Arm PF00514.23 KOO31372.1 - 1.8e-69 227.9 39.2 4.7e-07 29.6 0.3 16.4 17 0 0 17 17 17 13 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 KOO31372.1 - 1.2e-08 34.7 3.8 0.42 10.0 0.0 6.1 2 2 2 5 5 5 3 Armadillo-like V-ATPase_H_N PF03224.14 KOO31372.1 - 5.6e-08 32.4 0.0 0.072 12.4 0.0 4.2 1 1 1 3 3 3 2 V-ATPase subunit H KAP PF05804.12 KOO31372.1 - 9.8e-06 24.0 0.0 3.8e-05 22.0 0.0 1.9 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) Cnd1 PF12717.7 KOO31372.1 - 0.00095 19.2 0.4 0.66 10.0 0.0 4.7 5 1 1 6 6 6 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOO31372.1 - 0.0034 17.5 12.3 7.6 7.1 0.0 8.0 8 0 0 8 8 7 1 HEAT repeat Adaptin_N PF01602.20 KOO31372.1 - 0.0043 15.7 4.4 3.5 6.1 0.4 3.7 2 1 0 3 3 3 2 Adaptin N terminal region RTTN_N PF14726.6 KOO31372.1 - 0.013 16.3 0.3 5.4 7.9 0.0 3.7 5 0 0 5 5 4 0 Rotatin, an armadillo repeat protein, centriole functioning RTP1_C1 PF10363.9 KOO31372.1 - 0.034 14.3 0.3 0.71 10.1 0.0 3.4 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 KOO31372.1 - 2.2 8.8 45.6 0.34 11.3 3.3 7.8 2 2 5 8 8 8 0 HEAT repeats HEAT_EZ PF13513.6 KOO31372.1 - 3.2 8.4 33.7 2.2 8.9 0.7 8.4 5 1 3 8 8 8 0 HEAT-like repeat Arm PF00514.23 KOO31373.1 - 5.4e-65 213.6 49.9 3.8e-06 26.7 0.1 18.5 18 1 1 19 19 19 14 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO31373.1 - 1.4e-12 47.5 3.7 0.077 13.0 0.0 7.6 4 3 4 8 8 8 4 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_C PF11698.8 KOO31373.1 - 4.6e-05 23.5 0.5 0.87 9.7 0.0 3.7 2 1 1 3 3 3 2 V-ATPase subunit H DUF5578 PF17741.1 KOO31373.1 - 0.0062 16.0 10.6 0.5 9.7 1.0 4.3 2 1 3 5 5 5 3 Family of unknown function (DUF5578) Adaptin_N PF01602.20 KOO31373.1 - 0.0096 14.5 4.9 0.039 12.5 2.9 2.7 2 1 1 3 3 3 2 Adaptin N terminal region HEAT_EZ PF13513.6 KOO31373.1 - 0.098 13.2 49.9 1.8 9.2 1.5 10.3 6 2 6 12 12 12 0 HEAT-like repeat HEAT PF02985.22 KOO31373.1 - 2 8.9 24.1 0.97 9.9 0.1 9.5 10 0 0 10 10 10 0 HEAT repeat DUF3361 PF11841.8 KOO31373.1 - 2.4 8.1 7.5 8.1 6.4 1.4 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF3361) DUF2993 PF11209.8 KOO31374.1 - 3.6e-09 37.2 4.8 5.7e-09 36.5 4.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2993) Sulfotransfer_2 PF03567.14 KOO31375.1 - 0.0055 16.6 0.0 0.056 13.4 0.0 2.1 1 1 0 1 1 1 1 Sulfotransferase family B9-C2 PF07162.11 KOO31377.1 - 4.7e-33 114.8 0.0 5.4e-33 114.6 0.0 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Thioredoxin_3 PF13192.6 KOO31377.1 - 0.097 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Pkinase PF00069.25 KOO31378.1 - 8.8e-13 48.2 0.0 1.1e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31378.1 - 1.2e-07 31.3 0.0 1.5e-07 31.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO31378.1 - 0.0035 17.3 0.0 0.0038 17.2 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family CBM_19 PF03427.13 KOO31378.1 - 0.02 14.9 0.0 0.041 13.9 0.0 1.6 2 0 0 2 2 2 0 Carbohydrate binding domain (family 19) EF-hand_1 PF00036.32 KOO31379.1 - 1.2e-18 65.2 0.3 1.4e-05 24.3 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO31379.1 - 2e-17 61.6 0.7 1.8e-05 24.3 0.0 3.9 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KOO31379.1 - 1e-16 59.6 0.8 1e-06 28.0 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO31379.1 - 1.8e-11 44.3 0.0 1.4e-08 35.0 0.0 2.9 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO31379.1 - 1.9e-09 37.3 0.3 0.00013 21.7 0.0 3.4 2 1 1 3 3 3 2 EF-hand domain pair TPR_2 PF07719.17 KOO31380.1 - 3e-11 42.5 1.5 0.0009 19.2 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO31380.1 - 5.2e-11 42.4 6.0 0.0057 17.4 0.3 4.1 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO31380.1 - 8.3e-10 39.0 3.1 6.2e-05 23.4 0.4 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO31380.1 - 1.1e-09 38.3 14.4 0.00012 22.2 1.0 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO31380.1 - 3.1e-09 37.3 2.8 9.8e-05 22.9 0.7 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO31380.1 - 5.1e-09 35.6 1.0 0.0035 17.1 0.1 3.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31380.1 - 8.2e-07 28.8 0.0 0.096 12.9 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 KOO31380.1 - 8.3e-07 29.3 4.4 3e-05 24.3 0.5 2.9 1 1 3 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO31380.1 - 1.5e-06 27.7 2.9 7e-06 25.4 1.1 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO31380.1 - 3.7e-06 26.5 0.6 0.042 13.5 0.0 2.7 2 0 0 2 2 2 2 TPR repeat TPR_6 PF13174.6 KOO31380.1 - 5.1e-06 26.8 3.8 3.5 8.5 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO31380.1 - 0.00033 20.8 0.1 1.2 9.7 0.0 3.9 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO31380.1 - 0.00096 19.0 1.6 4.6 7.5 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat FAT PF02259.23 KOO31380.1 - 0.001 18.4 0.1 0.029 13.6 0.5 2.0 1 1 1 2 2 2 1 FAT domain ANAPC3 PF12895.7 KOO31380.1 - 0.0014 18.8 3.5 0.22 11.8 1.5 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 KOO31380.1 - 0.0024 18.3 5.2 0.76 10.2 0.2 2.9 1 1 2 3 3 3 2 Bacterial transcriptional activator domain NARP1 PF12569.8 KOO31380.1 - 0.0049 15.8 0.0 0.65 8.8 0.0 2.0 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_12 PF13424.6 KOO31380.1 - 0.0058 16.9 7.7 0.13 12.6 0.2 3.5 1 1 1 3 3 3 1 Tetratricopeptide repeat DUF1347 PF07079.11 KOO31380.1 - 0.012 14.2 0.0 0.04 12.5 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1347) Clathrin PF00637.20 KOO31380.1 - 0.041 13.7 0.2 0.97 9.3 0.0 2.5 1 1 1 2 2 2 0 Region in Clathrin and VPS RPN7 PF10602.9 KOO31380.1 - 0.046 13.4 0.3 14 5.4 0.0 3.0 2 1 1 3 3 3 0 26S proteasome subunit RPN7 XOO_2897-deam PF14440.6 KOO31380.1 - 0.072 13.2 0.2 0.17 12.0 0.1 1.7 2 1 0 2 2 2 0 Xanthomonas XOO_2897-like deaminase Alkyl_sulf_dimr PF14863.6 KOO31380.1 - 0.086 13.3 0.5 8.8 6.8 0.3 2.2 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation SNAP PF14938.6 KOO31380.1 - 0.1 12.0 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_10 PF13374.6 KOO31380.1 - 0.47 10.4 3.9 6.7 6.7 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat PRORP PF16953.5 KOO31381.1 - 9.9e-20 71.1 0.0 1.5e-11 44.3 0.0 2.2 1 1 1 2 2 2 2 Protein-only RNase P PPR_long PF17177.4 KOO31381.1 - 4.7e-14 52.3 0.0 7.2e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP R3H PF01424.22 KOO31381.1 - 1.4e-05 25.0 0.0 9.5e-05 22.3 0.0 2.6 2 1 1 3 3 3 1 R3H domain PPR PF01535.20 KOO31381.1 - 0.062 13.6 0.1 4.9 7.6 0.0 3.2 4 0 0 4 4 4 0 PPR repeat RNase_Zc3h12a PF11977.8 KOO31381.1 - 0.15 11.9 0.1 0.43 10.3 0.1 1.8 1 1 1 2 2 2 0 Zc3h12a-like Ribonuclease NYN domain DUF677 PF05055.12 KOO31382.1 - 0.0024 16.9 0.3 0.0057 15.6 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF677) DUF713 PF05218.14 KOO31382.1 - 0.036 13.8 0.1 0.1 12.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF713) PSD5 PF07637.11 KOO31382.1 - 2.7 8.4 7.9 0.27 11.6 0.5 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1595) COG2 PF06148.11 KOO31382.1 - 3 8.0 8.5 0.64 10.1 0.9 2.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Herpes_UL36 PF03586.13 KOO31382.1 - 3.1 7.0 15.6 3.4 6.9 11.6 2.8 2 1 0 2 2 2 0 Herpesvirus UL36 tegument protein ShK PF01549.24 KOO31383.1 - 1.9e-15 57.1 41.6 2.1e-09 37.8 9.0 4.5 3 1 0 3 3 3 2 ShK domain-like 2OG-FeII_Oxy_3 PF13640.6 KOO31383.1 - 1.6e-14 54.6 0.1 2.8e-14 53.8 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pkinase PF00069.25 KOO31384.1 - 1.9e-44 152.1 0.0 1.3e-43 149.3 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31384.1 - 4.7e-24 85.1 0.0 1e-23 84.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO31384.1 - 0.062 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 KOO31384.1 - 0.16 11.5 0.0 0.22 11.1 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Ank_4 PF13637.6 KOO31385.1 - 7.1e-17 61.5 0.3 1.8e-09 37.9 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO31385.1 - 1.7e-12 47.7 0.1 4.3e-12 46.4 0.1 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO31385.1 - 3.1e-12 46.5 0.1 9e-10 38.6 0.1 2.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO31385.1 - 2e-11 43.0 0.4 2.7e-05 24.2 0.0 2.9 2 1 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KOO31385.1 - 2.2e-10 40.5 0.5 0.00083 19.7 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat Colicin_V PF02674.16 KOO31386.1 - 0.0033 17.4 1.8 0.49 10.4 1.3 2.4 2 0 0 2 2 2 2 Colicin V production protein YtpI PF14007.6 KOO31386.1 - 0.11 12.7 3.1 0.47 10.6 3.1 2.1 1 1 0 1 1 1 0 YtpI-like protein ERO1 PF04137.15 KOO31387.1 - 6.5e-84 282.1 0.0 7.7e-84 281.9 0.0 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) LRR_5 PF13306.6 KOO31388.1 - 1.1e-62 209.7 0.1 3.5e-31 107.8 0.0 2.0 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO31388.1 - 2.9e-09 36.6 0.0 0.12 12.1 0.0 3.7 1 1 3 4 4 4 3 Leucine rich repeat Peptidase_M8 PF01457.16 KOO31388.1 - 0.016 13.9 0.3 4.1 6.0 0.0 2.6 1 1 2 3 3 3 0 Leishmanolysin HRM PF02793.22 KOO31388.1 - 0.043 14.1 0.1 5 7.5 0.0 3.1 2 2 0 2 2 2 0 Hormone receptor domain ZoocinA_TRD PF16775.5 KOO31388.1 - 0.11 12.7 0.0 5.3 7.3 0.0 2.2 1 1 1 2 2 2 0 Target recognition domain of lytic exoenzyme Opi1 PF08618.10 KOO31388.1 - 0.13 11.5 0.0 2.2 7.4 0.0 2.2 1 1 1 2 2 2 0 Transcription factor Opi1 PARP PF00644.20 KOO31389.1 - 2.7e-11 43.5 0.2 1.6e-10 40.9 0.2 2.1 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain YqaJ PF09588.10 KOO31391.1 - 1.4e-19 70.7 0.0 2.4e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain YIF1 PF03878.15 KOO31392.1 - 2.9e-59 200.5 0.0 3.5e-59 200.2 0.0 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 KOO31392.1 - 0.00025 20.8 9.9 0.00074 19.3 9.7 1.9 1 1 0 1 1 1 1 Yip1 domain GWT1 PF06423.12 KOO31392.1 - 0.022 14.9 0.1 0.047 13.8 0.1 1.5 1 0 0 1 1 1 0 GWT1 Pkinase PF00069.25 KOO31393.1 - 5.5e-46 157.1 0.0 8.4e-46 156.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31393.1 - 5.3e-38 130.8 0.0 9e-38 130.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO31393.1 - 0.00029 19.7 0.0 0.00059 18.7 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO31393.1 - 0.0084 15.5 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO31393.1 - 0.045 13.7 0.2 0.56 10.1 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO31393.1 - 0.099 12.0 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VbhA PF18495.1 KOO31393.1 - 0.24 11.3 2.7 15 5.5 0.1 2.8 2 0 0 2 2 2 0 Antitoxin VbhA SpoU_methylase PF00588.19 KOO31395.1 - 5.4e-25 88.2 0.1 7.6e-25 87.7 0.1 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family FAD-oxidase_C PF02913.19 KOO31395.1 - 0.074 12.7 1.1 0.082 12.5 0.1 1.5 2 0 0 2 2 2 0 FAD linked oxidases, C-terminal domain TPT PF03151.16 KOO31396.1 - 1.1e-93 313.8 13.2 1.3e-93 313.5 13.2 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO31396.1 - 1.1e-10 41.8 29.0 2.4e-06 27.7 10.0 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO31396.1 - 6.9e-07 28.8 10.4 8.9e-06 25.1 7.1 2.4 1 1 0 2 2 2 2 UAA transporter family Tom22 PF04281.13 KOO31396.1 - 0.28 11.0 1.9 2.7 7.8 0.5 2.4 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 DUF1240 PF06836.12 KOO31396.1 - 1.1 9.9 7.6 1.6 9.3 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1240) WD40 PF00400.32 KOO31397.1 - 3e-53 176.6 15.0 7.8e-10 39.2 0.3 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO31397.1 - 1.3e-17 63.8 3.9 0.0091 15.0 0.0 5.0 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO31397.1 - 2.9e-15 55.7 1.2 0.052 13.5 0.0 5.4 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 KOO31397.1 - 1.4e-13 51.0 1.4 0.04 14.2 0.0 4.9 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO31397.1 - 1.2e-09 38.3 0.5 2.5e-05 24.2 0.2 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 KOO31397.1 - 7.2e-08 31.2 0.0 0.097 11.0 0.0 4.1 1 1 3 4 4 4 4 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO31397.1 - 1.6e-06 27.7 3.3 0.74 9.1 0.1 4.4 1 1 4 5 5 5 3 Neuroblastoma-amplified sequence, N terminal Plk4_PB1 PF18190.1 KOO31397.1 - 3.4e-06 27.2 0.3 6 7.1 0.0 4.7 1 1 4 5 5 5 1 Polo-like Kinase 4 Polo Box 1 WD40_like PF17005.5 KOO31397.1 - 8.5e-05 22.0 0.4 0.2 11.0 0.0 3.0 1 1 1 3 3 3 3 WD40-like domain DCX PF03607.17 KOO31397.1 - 0.00037 20.5 0.0 26 5.0 0.0 4.9 5 0 0 5 5 5 0 Doublecortin WD40_3 PF15911.5 KOO31397.1 - 0.0031 17.5 0.2 23 5.1 0.0 4.6 5 0 0 5 5 5 0 WD domain, G-beta repeat Ribosomal_L18p PF00861.22 KOO31397.1 - 0.0095 16.3 0.5 0.025 15.0 0.5 1.8 1 1 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast DpaA_N PF16924.5 KOO31397.1 - 0.062 13.4 0.0 5.8 7.0 0.0 2.9 1 1 2 3 3 3 0 Dipicolinate synthase subunit A N-terminal domain Carla_C4 PF01623.17 KOO31397.1 - 1.2 9.1 8.3 2.2 8.3 8.3 1.4 1 0 0 1 1 1 0 Carlavirus putative nucleic acid binding protein Proteasome_A_N PF10584.9 KOO31397.1 - 2.5 7.8 13.1 1.1e+02 2.7 0.1 5.7 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature PPR_2 PF13041.6 KOO31398.1 - 7.9e-130 423.0 10.9 4.3e-14 52.4 0.0 13.1 1 1 13 14 14 14 14 PPR repeat family PPR_1 PF12854.7 KOO31398.1 - 1.3e-98 322.3 0.8 8.9e-10 38.1 0.0 14.0 14 0 0 14 14 14 13 PPR repeat PPR PF01535.20 KOO31398.1 - 5.1e-93 299.1 6.7 7.7e-07 29.0 0.0 14.3 14 0 0 14 14 14 14 PPR repeat PPR_3 PF13812.6 KOO31398.1 - 6.6e-90 295.2 0.0 1.3e-13 50.8 0.0 8.5 7 2 1 8 8 8 8 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO31398.1 - 1.1e-59 201.4 5.0 7.4e-21 74.5 0.2 5.2 1 1 3 5 5 5 5 Pentacotripeptide-repeat region of PRORP MRP-S27 PF10037.9 KOO31398.1 - 6.2e-12 45.1 0.5 0.031 13.2 0.0 5.1 2 1 3 5 5 5 4 Mitochondrial 28S ribosomal protein S27 ECSIT PF06239.11 KOO31398.1 - 1.7e-08 33.9 0.0 13 4.8 0.0 7.8 3 2 3 7 7 7 1 Evolutionarily conserved signalling intermediate in Toll pathway Clathrin PF00637.20 KOO31398.1 - 7.1e-08 32.4 0.0 0.89 9.4 0.0 5.2 4 1 1 5 5 5 3 Region in Clathrin and VPS GMP_synt_C PF00958.22 KOO31398.1 - 3.3e-06 27.0 0.4 2.7 8.1 0.0 7.5 4 2 7 11 11 11 1 GMP synthase C terminal domain Vps23_core PF09454.10 KOO31398.1 - 0.0027 17.6 0.0 2.5 8.1 0.0 4.2 2 1 3 5 5 5 1 Vps23 core domain TPR_7 PF13176.6 KOO31398.1 - 0.04 14.0 0.0 1.9 8.7 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO31398.1 - 0.13 12.5 0.8 16 5.8 0.0 3.5 3 0 0 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KOO31398.1 - 0.13 12.8 7.7 3.5 8.2 0.1 4.8 5 1 1 6 6 5 0 Tetratricopeptide repeat TH1 PF04858.13 KOO31399.1 - 7.1e-38 130.6 0.0 1.3e-19 70.3 0.0 2.1 2 0 0 2 2 2 2 TH1 protein Glycogen_syn PF05693.13 KOO31399.1 - 0.063 11.8 0.0 0.085 11.4 0.0 1.1 1 0 0 1 1 1 0 Glycogen synthase Phage_lysis PF03245.13 KOO31400.1 - 0.00013 22.1 3.1 0.0002 21.5 3.1 1.3 1 0 0 1 1 1 1 Bacteriophage Rz lysis protein DASH_Spc19 PF08287.11 KOO31400.1 - 0.0012 18.7 0.6 0.0017 18.3 0.6 1.2 1 0 0 1 1 1 1 Spc19 DLIC PF05783.11 KOO31400.1 - 0.0015 17.4 0.8 0.002 17.0 0.8 1.2 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) Snapin_Pallidin PF14712.6 KOO31400.1 - 0.0029 18.0 0.3 0.0052 17.2 0.3 1.5 1 0 0 1 1 1 1 Snapin/Pallidin TMF_TATA_bd PF12325.8 KOO31400.1 - 0.0057 16.9 3.7 0.01 16.1 3.7 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding DUF773 PF05600.12 KOO31400.1 - 0.0065 15.3 0.1 0.0085 14.9 0.1 1.1 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 Dynamitin PF04912.14 KOO31400.1 - 0.024 14.0 0.2 0.03 13.7 0.2 1.1 1 0 0 1 1 1 0 Dynamitin DUF1640 PF07798.11 KOO31400.1 - 0.043 13.9 1.1 0.064 13.3 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Lectin_N PF03954.14 KOO31400.1 - 0.043 13.6 0.4 0.09 12.5 0.4 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Ax_dynein_light PF10211.9 KOO31400.1 - 0.044 13.7 0.5 0.059 13.3 0.5 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain Phage_Mu_Gam PF07352.12 KOO31400.1 - 0.063 13.2 2.7 0.092 12.6 2.7 1.2 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein DivIC PF04977.15 KOO31400.1 - 0.079 12.7 0.4 0.14 11.9 0.4 1.4 1 0 0 1 1 1 0 Septum formation initiator Herpes_UL6 PF01763.16 KOO31400.1 - 0.16 10.5 0.0 0.19 10.2 0.0 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like FlaC_arch PF05377.11 KOO31400.1 - 0.21 12.0 0.6 0.69 10.3 0.5 1.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 KOO31400.1 - 0.23 10.7 0.3 0.33 10.2 0.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF5315 PF17242.2 KOO31400.1 - 0.68 9.8 5.4 0.19 11.6 2.0 1.7 2 0 0 2 2 2 0 Disordered region of unknown function (DUF5315) Carn_acyltransf PF00755.20 KOO31401.1 - 5.2e-162 540.5 0.0 7.9e-162 539.9 0.0 1.3 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Zn_Tnp_IS91 PF14319.6 KOO31401.1 - 0.11 12.5 0.2 0.3 11.1 0.2 1.7 1 0 0 1 1 1 0 Transposase zinc-binding domain zf-tcix PF14952.6 KOO31401.1 - 0.18 11.4 3.1 0.41 10.3 3.1 1.5 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding DUF2388 PF09498.10 KOO31401.1 - 4.6 7.3 6.7 1.3 9.0 1.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2388) Msg2_C PF12373.8 KOO31404.1 - 0.18 11.3 1.1 27 4.3 0.1 3.1 3 0 0 3 3 3 0 Major surface glycoprotein 2 C terminal PKD_channel PF08016.12 KOO31405.1 - 7.9e-25 87.4 16.2 2.5e-23 82.4 17.6 2.1 2 0 0 2 2 2 1 Polycystin cation channel EF-hand_1 PF00036.32 KOO31405.1 - 1.9e-09 36.4 0.2 0.00051 19.4 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31405.1 - 5.7e-08 32.1 0.1 0.001 18.8 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO31405.1 - 8.2e-07 29.4 0.1 2.3e-06 27.9 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO31405.1 - 0.00031 20.1 0.2 1 9.0 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO31405.1 - 0.00052 19.8 0.4 1.4 8.8 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO31405.1 - 0.0012 19.1 0.0 0.0029 17.9 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO31405.1 - 0.16 12.0 0.1 0.37 10.8 0.1 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DUF3270 PF11674.8 KOO31405.1 - 0.23 11.7 0.1 0.23 11.7 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3270) Mon1 PF03164.14 KOO31406.1 - 1.9e-106 356.6 0.0 2.4e-106 356.2 0.0 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 ACT PF01842.25 KOO31406.1 - 2.2e-12 46.5 3.4 5.2e-08 32.5 0.3 3.0 2 1 0 2 2 2 2 ACT domain ACT_4 PF13291.6 KOO31406.1 - 5.4e-05 23.7 0.3 0.061 13.9 0.0 2.5 2 0 0 2 2 2 2 ACT domain Importin_rep_6 PF18829.1 KOO31406.1 - 0.12 12.5 1.9 0.34 11.1 1.9 1.7 1 0 0 1 1 1 0 Importin repeat 6 ACT_7 PF13840.6 KOO31406.1 - 0.18 11.6 3.1 6.8 6.6 0.1 2.7 2 0 0 2 2 2 0 ACT domain PBP1_TM PF14812.6 KOO31406.1 - 1.8 9.0 4.6 6.3 7.2 4.6 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 KOO31406.1 - 3.9 7.9 7.4 12 6.3 7.4 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_ligase_A_M PF01068.21 KOO31407.1 - 1.8e-40 138.8 0.0 2.8e-40 138.2 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KOO31407.1 - 3.5e-17 63.3 0.0 7.1e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus zf-PARP PF00645.18 KOO31407.1 - 3.4e-16 59.9 0.0 7.2e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DNA_ligase_A_C PF04679.15 KOO31407.1 - 1.1e-11 45.2 0.0 3.4e-11 43.6 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region zf-CCHH PF10283.9 KOO31407.1 - 2.4e-11 43.4 3.7 5.1e-11 42.4 3.7 1.5 1 0 0 1 1 1 1 PBZ domain RNA_ligase PF09414.10 KOO31407.1 - 6.1e-07 29.9 0.0 3.4e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 RNA ligase WWE PF02825.20 KOO31407.1 - 3e-05 24.5 0.1 6.3e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 WWE domain mRNA_cap_enzyme PF01331.19 KOO31407.1 - 0.16 11.7 0.0 0.51 10.1 0.0 1.8 1 1 1 2 2 2 0 mRNA capping enzyme, catalytic domain kleA_kleC PF17383.2 KOO31407.1 - 0.94 9.8 3.2 0.7 10.3 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A FAM176 PF14851.6 KOO31407.1 - 6.1 6.5 6.2 9.6 5.9 1.5 2.4 2 0 0 2 2 2 0 FAM176 family PAS_3 PF08447.12 KOO31408.1 - 2.7e-37 126.9 0.1 7.6e-10 39.0 0.0 5.0 5 0 0 5 5 5 4 PAS fold PAS_11 PF14598.6 KOO31408.1 - 6.7e-21 74.5 0.0 7.8e-07 29.2 0.0 4.6 4 0 0 4 4 4 4 PAS domain PAS PF00989.25 KOO31408.1 - 1.4e-18 67.0 0.0 0.00017 21.6 0.0 4.6 4 0 0 4 4 4 3 PAS fold PAS_9 PF13426.7 KOO31408.1 - 4.5e-18 65.4 0.0 0.00016 21.9 0.0 4.6 5 0 0 5 5 5 3 PAS domain PAS_4 PF08448.10 KOO31408.1 - 2.5e-15 56.7 0.3 0.00017 21.8 0.0 4.7 4 0 0 4 4 4 4 PAS fold PAS_8 PF13188.7 KOO31408.1 - 5.6e-05 23.1 0.0 2.6 8.1 0.0 3.4 3 0 0 3 3 3 2 PAS domain PAS_2 PF08446.11 KOO31408.1 - 0.0029 18.3 0.0 33 5.2 0.0 4.1 4 0 0 4 4 4 0 PAS fold AAA_5 PF07728.14 KOO31408.1 - 0.17 11.9 0.0 0.38 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Glyoxalase PF00903.25 KOO31409.1 - 5.6e-06 26.6 0.0 3.9e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 KOO31409.1 - 1.2e-05 25.5 0.0 0.022 15.0 0.0 2.5 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.6 KOO31409.1 - 0.0031 17.7 0.2 0.024 14.8 0.1 2.2 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_3 PF13468.6 KOO31409.1 - 0.011 15.9 1.2 14 5.8 0.0 3.7 4 0 0 4 4 4 0 Glyoxalase-like domain TPT PF03151.16 KOO31410.1 - 8e-54 183.0 8.1 1.1e-53 182.5 8.1 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO31410.1 - 0.00047 20.3 10.7 0.0089 16.2 2.3 2.5 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO31410.1 - 0.0078 15.5 6.2 0.012 14.8 6.2 1.2 1 0 0 1 1 1 1 UAA transporter family Met_10 PF02475.16 KOO31410.1 - 0.018 14.8 0.1 0.047 13.4 0.0 1.7 2 0 0 2 2 2 0 Met-10+ like-protein DUF747 PF05346.11 KOO31410.1 - 0.049 13.1 0.5 0.089 12.2 0.5 1.3 1 0 0 1 1 1 0 Eukaryotic membrane protein family Methyltransf_21 PF05050.12 KOO31410.1 - 0.063 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase FkbM domain efb-c PF12199.8 KOO31410.1 - 0.64 10.1 2.0 1.6 8.9 2.0 1.6 1 0 0 1 1 1 0 Extracellular fibrinogen binding protein C terminal LSDAT_euk PF18139.1 KOO31412.1 - 7.5e-42 143.6 0.3 1.2e-41 142.9 0.3 1.3 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 KOO31412.1 - 2.7e-25 88.8 0.8 5.7e-25 87.7 0.8 1.5 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 KOO31412.1 - 6.7e-08 32.1 6.7 2.8e-07 30.0 6.7 2.0 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO31412.1 - 2.6e-05 23.1 1.7 5.1e-05 22.1 1.7 1.4 1 0 0 1 1 1 1 Polycystin cation channel DUF4184 PF13803.6 KOO31412.1 - 0.039 13.7 1.5 0.097 12.4 1.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4184) SRPRB PF09439.10 KOO31413.1 - 7.5e-28 97.2 0.0 9.6e-28 96.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 KOO31413.1 - 6.4e-08 32.2 0.0 8.8e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO31413.1 - 1.7e-05 24.9 0.0 0.00014 21.9 0.0 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOO31413.1 - 0.00026 20.6 0.0 0.0038 16.8 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 KOO31413.1 - 0.0063 16.8 0.0 0.023 15.0 0.0 1.8 1 1 1 2 2 2 1 AAA domain Roc PF08477.13 KOO31413.1 - 0.041 14.1 0.0 0.066 13.4 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_PrkA PF08298.11 KOO31413.1 - 0.065 12.1 0.0 0.094 11.6 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain DUF1129 PF06570.11 KOO31413.1 - 0.21 11.1 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Hydrolase_4 PF12146.8 KOO31415.1 - 1.5e-30 106.2 0.1 9.3e-29 100.4 0.0 2.5 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO31415.1 - 7.3e-13 49.6 1.5 2e-12 48.2 0.1 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO31415.1 - 9.5e-12 45.1 0.2 4.6e-10 39.6 0.3 2.5 3 0 0 3 3 3 1 alpha/beta hydrolase fold E3_UbLigase_R4 PF13764.6 KOO31416.1 - 3e-176 588.0 0.0 9.4e-124 414.4 0.0 3.1 1 1 2 3 3 3 3 E3 ubiquitin-protein ligase UBR4 ZZ PF00569.17 KOO31416.1 - 4.9e-11 42.3 11.2 4.9e-11 42.3 11.2 3.7 3 0 0 3 3 3 2 Zinc finger, ZZ type NLE PF08154.12 KOO31416.1 - 0.0079 16.7 0.1 2 9.0 0.0 3.1 3 0 0 3 3 3 1 NLE (NUC135) domain FANCI_S4 PF14678.6 KOO31416.1 - 0.075 12.1 0.0 0.18 10.9 0.0 1.6 1 0 0 1 1 1 0 FANCI solenoid 4 Ion_trans PF00520.31 KOO31417.1 - 3.1e-10 39.7 5.2 6.8e-10 38.6 5.1 1.7 1 1 0 1 1 1 1 Ion transport protein NUDIX PF00293.28 KOO31417.1 - 8e-08 32.4 0.0 2.6e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain PKD_channel PF08016.12 KOO31417.1 - 0.012 14.3 8.9 4 6.0 8.8 3.1 2 1 0 2 2 2 0 Polycystin cation channel Terminase_6C PF17289.2 KOO31417.1 - 0.071 13.2 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 Terminase RNaseH-like domain HC2 PF07382.11 KOO31418.1 - 1.8 8.6 53.4 0.13 12.3 40.5 2.1 1 1 1 2 2 2 0 Histone H1-like nucleoprotein HC2 Glyco_hydro_31 PF01055.26 KOO31419.1 - 9.3e-131 437.0 1.2 1.5e-117 393.5 0.4 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 KOO31419.1 - 6e-18 64.9 0.1 3e-17 62.7 0.0 2.2 2 0 0 2 2 2 1 Galactose mutarotase-like Calreticulin PF00262.18 KOO31419.1 - 0.0052 15.7 0.2 0.008 15.1 0.2 1.1 1 0 0 1 1 1 1 Calreticulin family PC-Esterase PF13839.6 KOO31420.1 - 9.5e-09 35.4 0.0 1.2e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p RCC1_2 PF13540.6 KOO31420.1 - 0.17 11.8 0.4 0.53 10.1 0.0 2.1 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat Arm PF00514.23 KOO31421.1 - 7.5e-39 130.6 21.4 1.9e-09 37.2 0.0 9.8 10 0 0 10 10 10 6 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KOO31421.1 - 3.2e-17 61.1 10.4 0.00072 19.6 0.0 8.3 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 KOO31421.1 - 1.2e-16 60.8 15.2 0.00019 21.7 0.2 5.5 3 2 2 5 5 5 5 HEAT repeats HEAT_EZ PF13513.6 KOO31421.1 - 2.8e-14 53.3 16.5 0.00037 20.9 0.4 7.3 6 1 1 7 7 7 4 HEAT-like repeat Cnd1 PF12717.7 KOO31421.1 - 1.3e-12 48.0 0.4 0.0078 16.3 0.1 4.1 2 2 3 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KOO31421.1 - 4.1e-08 32.3 1.4 0.0022 16.6 0.7 3.6 2 1 1 3 3 3 2 Adaptin N terminal region DNA_alkylation PF08713.11 KOO31421.1 - 1.3e-07 31.6 0.0 0.72 9.5 0.0 3.7 3 1 0 3 3 3 3 DNA alkylation repair enzyme Proteasom_PSMB PF10508.9 KOO31421.1 - 4.3e-07 28.8 1.2 0.00041 19.0 0.1 2.9 1 1 2 3 3 3 2 Proteasome non-ATPase 26S subunit CLASP_N PF12348.8 KOO31421.1 - 1e-05 25.2 0.3 0.55 9.8 0.0 3.5 3 0 0 3 3 3 2 CLASP N terminal CHASE6_C PF17150.4 KOO31421.1 - 3.1e-05 24.6 0.8 35 5.2 0.0 6.4 6 1 0 7 7 7 0 C-terminal domain of two-partite extracellular sensor domain V-ATPase_H_C PF11698.8 KOO31421.1 - 0.00036 20.6 0.2 32 4.7 0.0 4.3 3 1 1 4 4 4 0 V-ATPase subunit H API5 PF05918.11 KOO31421.1 - 0.0009 18.2 0.3 2.9 6.6 0.0 3.5 1 1 2 3 3 3 1 Apoptosis inhibitory protein 5 (API5) GatB_Yqey PF02637.18 KOO31421.1 - 0.0078 16.1 0.1 1.4 8.8 0.0 3.7 5 0 0 5 5 4 1 GatB domain Mo25 PF08569.11 KOO31421.1 - 0.021 14.2 0.1 3.5 6.9 0.0 2.9 1 1 0 2 2 2 0 Mo25-like HEAT_UF PF18817.1 KOO31421.1 - 0.033 14.5 0.1 3.1 8.1 0.0 3.5 3 0 0 3 3 3 0 Repeat of uncharacterized protein PH0542 HEAT_PBS PF03130.16 KOO31421.1 - 0.27 12.0 17.6 0.73 10.7 0.2 6.8 8 0 0 8 8 7 0 PBS lyase HEAT-like repeat DUF2274 PF10038.9 KOO31422.1 - 0.091 13.2 0.3 2.1 8.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2274) RPE65 PF03055.15 KOO31423.1 - 3.3e-57 194.7 0.0 1.7e-28 100.0 0.0 2.0 1 1 1 2 2 2 2 Retinal pigment epithelial membrane protein Cupin_3 PF05899.12 KOO31424.1 - 2e-06 27.4 1.3 0.0013 18.3 0.3 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Cupin_2 PF07883.11 KOO31424.1 - 5.3e-05 22.9 0.0 0.17 11.6 0.0 2.3 2 0 0 2 2 2 2 Cupin domain AraC_binding_2 PF14525.6 KOO31424.1 - 0.0016 18.1 0.1 1.3 8.6 0.1 2.2 2 0 0 2 2 2 2 AraC-binding-like domain AgrD PF05931.11 KOO31424.1 - 0.15 12.1 0.2 0.97 9.5 0.1 2.1 2 0 0 2 2 2 0 Staphylococcal AgrD protein EF-hand_1 PF00036.32 KOO31425.1 - 4.7e-24 82.1 4.2 1.2e-05 24.5 0.2 5.0 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 KOO31425.1 - 6.1e-24 81.9 1.0 6.8e-05 22.5 0.1 4.9 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO31425.1 - 6.8e-22 75.9 7.1 1.1e-05 24.6 0.1 5.1 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO31425.1 - 1.8e-19 69.9 1.2 3.4e-10 40.2 0.0 4.1 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO31425.1 - 2e-14 53.2 0.5 5.3e-06 26.2 0.0 5.0 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO31425.1 - 0.00014 22.1 1.2 0.00078 19.8 0.0 2.7 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1471 PF07338.13 KOO31425.1 - 0.065 13.2 2.3 9 6.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1471) RepB PF07506.11 KOO31426.1 - 0.067 13.3 0.1 0.09 12.9 0.1 1.1 1 0 0 1 1 1 0 RepB plasmid partitioning protein FA_desaturase PF00487.24 KOO31427.1 - 7.6e-22 78.4 14.2 2.6e-21 76.6 14.2 1.8 1 1 0 1 1 1 1 Fatty acid desaturase EF-hand_6 PF13405.6 KOO31429.1 - 4.2e-09 35.6 0.5 0.00097 18.9 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO31429.1 - 1.2e-06 28.8 0.0 2.8e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO31429.1 - 1.5e-06 27.3 0.0 0.012 15.1 0.0 2.5 2 0 0 2 2 2 2 EF hand BUD22 PF09073.10 KOO31429.1 - 0.00033 20.1 17.5 0.00042 19.8 17.5 1.1 1 0 0 1 1 1 1 BUD22 AP3D1 PF06375.11 KOO31429.1 - 0.0033 17.7 19.0 0.074 13.3 3.7 2.2 2 0 0 2 2 2 2 AP-3 complex subunit delta-1 EF-hand_5 PF13202.6 KOO31429.1 - 0.046 13.2 0.0 1.8 8.2 0.0 2.5 2 0 0 2 2 2 0 EF hand DUF3381 PF11861.8 KOO31429.1 - 0.14 12.0 17.9 1.2 9.0 1.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) RNA_polI_A34 PF08208.11 KOO31429.1 - 0.3 11.2 24.9 1.5 8.8 10.9 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 SRP9-21 PF05486.12 KOO31429.1 - 1.5 9.3 6.8 0.94 9.9 0.1 2.6 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) SR-25 PF10500.9 KOO31429.1 - 1.6 8.3 25.8 0.29 10.7 10.3 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein U3_snoRNA_assoc PF08297.11 KOO31429.1 - 2.3 9.0 21.3 3.3 8.5 8.7 2.6 2 0 0 2 2 2 0 U3 snoRNA associated Peptidase_S49_N PF08496.10 KOO31429.1 - 3.3 7.8 15.9 9.7 6.2 8.3 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TFIIF_alpha PF05793.12 KOO31429.1 - 6.2 5.3 29.2 1 7.9 8.4 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PRC2_HTH_1 PF18118.1 KOO31429.1 - 9.9 7.0 13.3 3.7 8.4 1.9 2.5 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Lon_C PF05362.13 KOO31430.1 - 4.1e-75 251.8 1.5 1.2e-74 250.3 1.5 1.8 1 1 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 KOO31430.1 - 2.2e-22 79.9 0.0 4.4e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO31430.1 - 1.1e-09 38.5 0.0 1.9e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 KOO31430.1 - 1.1e-06 28.5 0.1 6.4e-06 26.0 0.0 2.2 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.11 KOO31430.1 - 1.3e-06 27.6 0.0 2.1e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_2 PF07724.14 KOO31430.1 - 8.8e-05 22.7 0.0 0.0031 17.7 0.0 2.7 1 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOO31430.1 - 0.00012 22.4 0.0 0.0032 17.7 0.0 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KOO31430.1 - 0.00013 21.7 0.0 0.0004 20.2 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO31430.1 - 0.00028 21.3 0.4 0.017 15.5 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain IstB_IS21 PF01695.17 KOO31430.1 - 0.0024 17.6 0.0 0.0069 16.1 0.0 1.8 1 1 0 1 1 1 1 IstB-like ATP binding protein RsgA_GTPase PF03193.16 KOO31430.1 - 0.006 16.5 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase AAA_3 PF07726.11 KOO31430.1 - 0.012 15.5 0.0 0.031 14.1 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Birna_VP4 PF01768.16 KOO31430.1 - 0.021 14.6 3.4 0.49 10.2 0.1 2.7 2 1 1 3 3 3 0 Birnavirus VP4 protein NTPase_1 PF03266.15 KOO31430.1 - 0.023 14.6 0.0 0.36 10.7 0.0 2.3 1 1 1 2 2 2 0 NTPase OMPdecase PF00215.24 KOO31430.1 - 0.049 13.2 0.4 0.075 12.6 0.4 1.2 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family NACHT PF05729.12 KOO31430.1 - 0.054 13.4 0.0 0.16 11.8 0.0 1.8 1 0 0 1 1 1 0 NACHT domain MCM PF00493.23 KOO31430.1 - 0.065 12.3 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain DUF724 PF05266.14 KOO31430.1 - 0.076 12.8 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) AAA_24 PF13479.6 KOO31430.1 - 0.17 11.6 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KOO31430.1 - 0.22 12.0 0.0 0.38 11.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase ACC_epsilon PF13822.6 KOO31430.1 - 2.4 8.9 9.0 6.2 7.6 9.0 1.7 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit PUB PF09409.10 KOO31431.1 - 3.3e-08 33.3 0.0 5.4e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 PUB domain DnaJ PF00226.31 KOO31432.1 - 3.4e-18 65.5 1.0 6.1e-18 64.7 1.0 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.11 KOO31432.1 - 1.1e-16 61.0 0.0 1.9e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) MORN PF02493.20 KOO31434.1 - 0.022 14.6 1.0 0.69 9.9 0.1 3.3 2 1 1 3 3 3 0 MORN repeat FHA PF00498.26 KOO31435.1 - 2.7e-13 50.1 0.0 4.2e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO31435.1 - 2.2e-09 37.5 0.0 1.2e-07 32.0 0.0 2.2 1 1 1 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain PTCB-BRCT PF12738.7 KOO31435.1 - 1.5e-07 31.2 0.0 2.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 KOO31435.1 - 4.3e-05 23.3 0.0 6.5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain Anoctamin PF04547.12 KOO31436.1 - 6.9e-07 28.5 0.1 1.8e-06 27.1 0.1 1.6 1 0 0 1 1 1 1 Calcium-activated chloride channel PHM7_cyt PF14703.6 KOO31436.1 - 0.0002 21.6 0.0 0.00039 20.7 0.0 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_7TM PF02714.15 KOO31436.1 - 0.086 12.1 4.3 0.05 12.9 0.4 2.2 2 0 0 2 2 2 0 Calcium-dependent channel, 7TM region, putative phosphate SHMT PF00464.19 KOO31437.1 - 1.7e-202 672.4 0.0 2e-202 672.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 KOO31437.1 - 1.6e-05 24.4 0.0 3.6e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KOO31437.1 - 0.089 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Ank_2 PF12796.7 KOO31439.1 - 0.0019 18.7 0.6 0.096 13.3 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO31439.1 - 0.04 14.5 0.0 0.14 12.8 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeats (many copies) FIST_C PF10442.9 KOO31439.1 - 0.11 12.5 0.1 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 FIST C domain KELK PF15796.5 KOO31440.1 - 0.0076 16.7 13.5 0.0076 16.7 13.5 3.2 3 1 2 5 5 5 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase Golgin_A5 PF09787.9 KOO31440.1 - 0.26 10.7 14.7 0.03 13.8 10.3 1.8 2 0 0 2 2 2 0 Golgin subfamily A member 5 LMBR1 PF04791.16 KOO31440.1 - 1.6 7.5 5.9 2.2 7.1 5.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein V_ATPase_I PF01496.19 KOO31440.1 - 2 6.3 6.6 2.6 5.8 6.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0242 PF06785.11 KOO31440.1 - 2.4 8.2 11.6 3.3 7.8 11.2 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus XhlA PF10779.9 KOO31440.1 - 3 8.1 10.1 3 8.1 1.3 3.6 1 1 2 3 3 3 0 Haemolysin XhlA PA26 PF04636.13 KOO31440.1 - 7.1 5.4 8.9 12 4.7 8.9 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GREB1 PF15782.5 KOO31440.1 - 9.4 3.2 7.3 12 2.9 7.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GLE1 PF07817.13 KOO31441.1 - 0.039 13.2 1.1 0.064 12.5 1.1 1.3 1 0 0 1 1 1 0 GLE1-like protein Lebercilin PF15619.6 KOO31441.1 - 0.11 12.2 8.3 0.21 11.2 8.3 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Cor1 PF04803.12 KOO31441.1 - 0.13 12.5 8.6 0.16 12.1 4.4 2.2 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Morc6_S5 PF17942.1 KOO31444.1 - 1.9e-10 40.9 0.0 6.6e-06 26.2 0.0 2.5 2 1 0 2 2 2 2 Morc6 ribosomal protein S5 domain 2-like HATPase_c_3 PF13589.6 KOO31444.1 - 1.5e-07 31.3 0.0 1.1e-06 28.5 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SQS_PSY PF00494.19 KOO31446.1 - 0.13 11.7 0.1 0.14 11.7 0.1 1.1 1 0 0 1 1 1 0 Squalene/phytoene synthase PGM_PMM_II PF02879.16 KOO31447.1 - 0.024 15.2 7.7 32 5.2 0.2 5.1 1 1 4 5 5 5 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II ANAPC3 PF12895.7 KOO31447.1 - 0.026 14.7 7.3 26 5.1 0.1 4.4 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3860 PF12976.7 KOO31447.1 - 0.032 14.2 3.3 37 4.4 0.1 4.5 5 0 0 5 5 5 0 Domain of Unknown Function with PDB structure (DUF3860) D_CNTX PF17492.2 KOO31447.1 - 0.46 10.7 12.6 48 4.2 0.2 4.3 4 0 0 4 4 4 0 Delta Ctenitoxins Ribosomal_S13_N PF08069.12 KOO31447.1 - 0.5 10.5 13.0 38 4.4 0.1 5.7 6 0 0 6 6 6 0 Ribosomal S13/S15 N-terminal domain Tipalpha PF16753.5 KOO31447.1 - 2.8 7.8 12.2 45 3.8 0.3 4.9 5 0 0 5 5 5 0 TNF-alpha-Inducing protein of Helicobacter Rep_fac_C PF08542.11 KOO31447.1 - 6.2 7.3 8.1 38 4.8 0.1 4.3 6 0 0 6 6 6 0 Replication factor C C-terminal domain PhyH PF05721.13 KOO31448.1 - 6.1e-05 23.4 0.1 9.1e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 KOO31448.1 - 0.037 14.9 0.0 0.075 13.9 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DEAD PF00270.29 KOO31451.1 - 5.7e-17 62.0 0.0 9.2e-16 58.1 0.0 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO31451.1 - 0.00018 21.9 0.0 0.00031 21.1 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO31451.1 - 0.041 13.9 0.0 0.068 13.2 0.0 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Glycos_trans_3N PF02885.17 KOO31451.1 - 0.19 11.6 1.5 0.24 11.3 0.2 1.9 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Pam16 PF03656.13 KOO31451.1 - 0.69 9.9 2.2 1 9.4 0.2 2.2 2 0 0 2 2 2 0 Pam16 bPH_6 PF10756.9 KOO31452.1 - 0.042 13.9 0.1 6.6 6.9 0.0 2.4 2 0 0 2 2 2 0 Bacterial PH domain TruB_C PF09142.11 KOO31452.1 - 0.058 13.2 0.3 0.13 12.0 0.1 1.7 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal IZUMO PF15005.6 KOO31454.1 - 0.18 12.3 0.6 0.34 11.4 0.1 1.6 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Transglycosylas PF06737.14 KOO31455.1 - 0.041 14.5 1.0 0.13 12.9 0.0 2.4 2 0 0 2 2 2 0 Transglycosylase-like domain DUF393 PF04134.12 KOO31455.1 - 0.13 13.7 3.4 0.81 11.0 3.4 2.5 1 1 0 1 1 1 0 Protein of unknown function, DUF393 zf-C3HC4_3 PF13920.6 KOO31455.1 - 0.31 11.0 10.8 0.089 12.7 6.2 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO31455.1 - 0.56 10.6 9.1 0.72 10.2 6.7 2.6 2 1 0 2 2 2 0 Ring finger domain DZR PF12773.7 KOO31455.1 - 7.6 6.6 9.9 25 5.0 3.6 3.4 2 1 0 2 2 2 0 Double zinc ribbon Gcd10p PF04189.13 KOO31456.1 - 0.13 11.3 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Gcd10p family DUF1336 PF07059.12 KOO31457.1 - 0.00048 20.3 0.0 0.00091 19.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) Aa_trans PF01490.18 KOO31458.1 - 1.6e-21 76.5 12.6 8.9e-18 64.2 3.0 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Glucosamine_iso PF01182.20 KOO31459.1 - 1.2e-31 110.4 0.2 1.5e-31 110.0 0.2 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF737 PF05300.11 KOO31461.1 - 0.0048 17.3 0.3 0.0067 16.8 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF737) Activator_LAG-3 PF11498.8 KOO31461.1 - 0.088 11.8 12.4 0.13 11.2 12.4 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Erf4 PF10256.9 KOO31461.1 - 0.094 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family Dzip-like_N PF13815.6 KOO31461.1 - 0.51 10.3 5.8 0.84 9.6 5.8 1.2 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal SNF2_N PF00176.23 KOO31463.1 - 6.8e-61 205.9 0.0 9.8e-61 205.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO31463.1 - 3.5e-19 69.2 0.0 6.2e-17 61.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 KOO31463.1 - 3e-07 29.9 0.0 1.1e-06 28.0 0.0 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 KOO31463.1 - 5.6e-07 29.7 0.0 1.3e-06 28.5 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO31463.1 - 2e-05 24.4 0.0 3.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase PHD PF00628.29 KOO31463.1 - 9.7e-05 22.2 4.2 0.0044 16.9 0.1 2.5 2 0 0 2 2 2 1 PHD-finger C5HCH PF17982.1 KOO31463.1 - 0.0073 16.4 5.8 0.0073 16.4 5.8 2.7 2 0 0 2 2 2 1 NSD Cys-His rich domain zf-AN1 PF01428.16 KOO31463.1 - 0.024 14.8 2.3 0.056 13.6 2.3 1.6 1 0 0 1 1 1 0 AN1-like Zinc finger zf-PHD-like PF15446.6 KOO31463.1 - 0.06 13.0 1.6 0.95 9.1 0.2 2.4 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain NOA36 PF06524.12 KOO31463.1 - 1.9 7.8 9.7 3.4 6.9 9.7 1.3 1 0 0 1 1 1 0 NOA36 protein RAWUL PF16207.5 KOO31464.1 - 2e-11 44.4 0.0 3.4e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like DUF3337 PF11816.8 KOO31464.1 - 0.00085 19.2 0.0 0.0029 17.5 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3337) G-alpha PF00503.20 KOO31465.1 - 1.7e-103 346.5 1.5 1.9e-103 346.3 1.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KOO31465.1 - 9.7e-17 61.0 0.6 2.7e-14 53.0 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOO31465.1 - 3e-05 23.5 4.4 0.00024 20.5 0.8 2.6 2 1 0 3 3 3 1 Gtr1/RagA G protein conserved region Roc PF08477.13 KOO31465.1 - 0.0087 16.3 0.2 3.2 8.0 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KOO31465.1 - 0.028 14.5 0.1 2.6 8.2 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase MINDY_DUB PF04424.13 KOO31466.1 - 3.8e-33 114.0 0.2 1.1e-32 112.5 0.1 1.9 2 0 0 2 2 2 1 MINDY deubiquitinase LRR_6 PF13516.6 KOO31467.1 - 8.2e-20 69.1 25.2 0.0091 16.0 0.0 10.9 11 0 0 11 11 11 7 Leucine Rich repeat LRR_4 PF12799.7 KOO31467.1 - 4e-08 33.4 6.8 0.26 11.8 0.0 6.7 6 1 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO31467.1 - 7.3e-07 28.9 0.7 61 4.8 0.1 7.2 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO31467.1 - 0.00019 21.2 6.7 54 3.7 0.0 6.7 5 2 0 5 5 5 0 Leucine rich repeat SpoU_sub_bind PF08032.12 KOO31467.1 - 0.0029 17.8 0.3 32 4.9 0.0 4.2 4 0 0 4 4 4 1 RNA 2'-O ribose methyltransferase substrate binding TPR_12 PF13424.6 KOO31469.1 - 0.00057 20.1 11.2 0.035 14.4 0.6 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO31469.1 - 0.0034 17.4 3.6 6.7 7.1 0.1 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO31469.1 - 0.0037 16.7 5.2 0.0037 16.7 5.2 2.3 2 0 0 2 2 2 1 MalT-like TPR region SNAP PF14938.6 KOO31469.1 - 0.078 12.4 0.0 0.19 11.1 0.0 1.6 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP PT PF04886.12 KOO31469.1 - 0.28 10.7 6.7 0.63 9.6 6.7 1.6 1 0 0 1 1 1 0 PT repeat TPR_19 PF14559.6 KOO31469.1 - 0.6 10.6 4.5 1 9.9 0.2 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat HemY_N PF07219.13 KOO31469.1 - 3.7 7.8 11.0 0.27 11.5 0.3 3.9 4 0 0 4 4 4 0 HemY protein N-terminus ERGIC_N PF13850.6 KOO31471.1 - 0.007 16.7 1.0 0.46 10.9 0.0 3.2 3 0 0 3 3 3 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) ABC2_membrane_2 PF12679.7 KOO31471.1 - 0.038 13.3 0.8 0.086 12.1 0.8 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein Claudin_3 PF06653.11 KOO31471.1 - 0.066 13.1 4.8 0.052 13.5 0.7 2.4 1 1 1 2 2 2 0 Tight junction protein, Claudin-like DUF5056 PF16479.5 KOO31471.1 - 0.23 11.7 2.5 0.26 11.6 0.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF5056) Cation_efflux PF01545.21 KOO31471.1 - 1.4 8.6 12.9 57 3.3 9.2 2.9 2 1 0 2 2 2 0 Cation efflux family Arm PF00514.23 KOO31472.1 - 1.1e-30 104.7 15.9 7.3e-08 32.2 0.3 5.8 5 0 0 5 5 5 5 Armadillo/beta-catenin-like repeat Rep-A_N PF04057.12 KOO31472.1 - 1.6e-26 92.2 2.5 3.1e-26 91.3 2.5 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain HEAT PF02985.22 KOO31472.1 - 0.026 14.8 6.8 9.2 6.8 0.0 5.7 6 0 0 6 6 6 0 HEAT repeat NucS PF01939.16 KOO31472.1 - 0.074 12.4 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Endonuclease NucS TRL PF13146.6 KOO31472.1 - 0.091 13.0 20.9 5.7 7.3 0.1 5.4 3 1 2 5 5 5 0 TRL-like protein family Succ_CoA_lig PF13607.6 KOO31472.1 - 0.11 12.3 18.4 1.5 8.6 2.3 4.1 2 1 2 4 4 4 0 Succinyl-CoA ligase like flavodoxin domain ParBc PF02195.18 KOO31472.1 - 0.12 12.6 0.2 82 3.6 0.0 3.9 4 0 0 4 4 4 0 ParB-like nuclease domain ChlamPMP_M PF07548.11 KOO31472.1 - 0.13 12.2 0.1 0.2 11.6 0.1 1.2 1 0 0 1 1 1 0 Chlamydia polymorphic membrane protein middle domain Peptidase_A24 PF01478.18 KOO31472.1 - 0.36 11.2 6.0 3.4 8.1 0.1 2.6 2 1 0 2 2 2 0 Type IV leader peptidase family HEAT_EZ PF13513.6 KOO31472.1 - 4.8 7.8 31.6 1.7 9.2 3.7 5.5 3 2 2 5 5 5 0 HEAT-like repeat Mg_trans_NIPA PF05653.14 KOO31473.1 - 2.5e-08 33.4 19.0 1.9e-05 23.9 1.7 2.6 3 0 0 3 3 3 2 Magnesium transporter NIPA SHOCT PF09851.9 KOO31473.1 - 0.0039 16.9 0.5 0.0073 16.0 0.5 1.5 1 0 0 1 1 1 1 Short C-terminal domain DUF910 PF06014.11 KOO31473.1 - 0.061 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) SURF6 PF04935.12 KOO31473.1 - 0.67 9.7 3.7 1 9.1 3.7 1.2 1 0 0 1 1 1 0 Surfeit locus protein 6 DUF2841 PF11001.8 KOO31475.1 - 0.072 13.1 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2841) GATase_6 PF13522.6 KOO31475.1 - 0.087 13.0 0.3 0.19 11.9 0.3 1.5 1 0 0 1 1 1 0 Glutamine amidotransferase domain DUF4407 PF14362.6 KOO31475.1 - 1.8 7.8 6.7 2.7 7.3 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Snf7 PF03357.21 KOO31476.1 - 4.7e-35 120.7 26.3 5.7e-35 120.4 26.3 1.0 1 0 0 1 1 1 1 Snf7 T2SSM_b PF10741.9 KOO31476.1 - 0.0037 17.0 0.2 0.0074 16.1 0.2 1.5 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein M subtype b Ist1 PF03398.14 KOO31476.1 - 0.0046 16.9 4.5 0.0056 16.6 4.2 1.4 1 1 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Integrase_H2C2 PF17921.1 KOO31476.1 - 0.043 13.9 0.4 13 6.0 0.1 2.4 2 0 0 2 2 2 0 Integrase zinc binding domain ACP_PD PF04336.12 KOO31476.1 - 0.17 12.3 5.0 0.5 10.8 1.2 2.4 2 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase Atg14 PF10186.9 KOO31476.1 - 0.48 9.4 6.3 0.72 8.9 6.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PIN_8 PF18476.1 KOO31476.1 - 0.6 9.9 9.6 2.5 7.9 10.0 1.7 1 1 0 1 1 1 0 PIN like domain 3HCDH_N PF02737.18 KOO31476.1 - 1.1 9.1 7.9 1.8 8.4 6.1 1.9 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DNA_pol_B PF00136.21 KOO31477.1 - 1.1e-44 152.9 0.0 2.2e-44 151.9 0.0 1.5 1 1 0 1 1 1 1 DNA polymerase family B zf-C4pol PF14260.6 KOO31477.1 - 1.7e-10 41.2 5.9 1.7e-10 41.2 5.9 1.8 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta Pro_isomerase PF00160.21 KOO31478.1 - 2.6e-42 144.8 0.1 2.8e-42 144.7 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Aha1_N PF09229.11 KOO31479.1 - 0.024 14.9 0.0 0.036 14.3 0.0 1.2 1 0 0 1 1 1 0 Activator of Hsp90 ATPase, N-terminal DNA_pol_B PF00136.21 KOO31480.1 - 1.7e-21 76.5 0.0 2.3e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KOO31480.1 - 9.1e-08 31.6 0.0 1.3e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain Bacteriocin_IIc PF10439.9 KOO31480.1 - 3.7 7.7 16.4 8.5 6.6 16.4 1.6 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Ion_trans PF00520.31 KOO31481.1 - 3.4e-79 265.5 11.3 1.4e-38 132.5 13.3 2.3 1 1 1 2 2 2 2 Ion transport protein PKD_channel PF08016.12 KOO31481.1 - 0.78 8.3 25.9 0.14 10.8 0.1 4.0 1 1 2 3 3 3 0 Polycystin cation channel Ion_trans PF00520.31 KOO31482.1 - 4e-17 62.3 0.6 4.6e-17 62.1 0.6 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO31482.1 - 0.034 12.8 0.4 0.041 12.6 0.4 1.0 1 0 0 1 1 1 0 Polycystin cation channel Ion_trans_2 PF07885.16 KOO31484.1 - 8.2e-15 54.5 11.9 1.6e-09 37.6 1.4 3.6 4 0 0 4 4 4 2 Ion channel Glyco_hydro_127 PF07944.12 KOO31485.1 - 3.7e-07 29.0 0.0 0.00065 18.3 0.0 3.0 3 0 0 3 3 3 3 Beta-L-arabinofuranosidase, GH127 Ion_trans_2 PF07885.16 KOO31486.1 - 2.2e-22 78.8 8.7 9.5e-12 44.7 0.2 2.8 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KOO31486.1 - 0.00024 20.4 1.2 0.0087 15.3 0.0 2.5 2 1 0 2 2 2 2 Ion transport protein PMP22_Claudin PF00822.20 KOO31486.1 - 0.045 13.6 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family PPR_2 PF13041.6 KOO31487.1 - 5.7e-92 301.8 11.4 2.8e-15 56.2 0.0 11.6 3 2 9 12 12 12 11 PPR repeat family PPR PF01535.20 KOO31487.1 - 8.3e-70 226.3 5.6 5.9e-07 29.3 0.0 12.6 12 0 0 12 12 12 12 PPR repeat PPR_3 PF13812.6 KOO31487.1 - 2e-64 213.6 0.0 3.3e-13 49.5 0.0 7.8 4 2 5 9 9 9 9 Pentatricopeptide repeat domain PPR_1 PF12854.7 KOO31487.1 - 3.1e-62 205.9 2.6 2.3e-08 33.6 0.0 12.3 12 0 0 12 12 12 9 PPR repeat PPR_long PF17177.4 KOO31487.1 - 7.5e-44 149.6 3.4 4.5e-21 75.2 0.3 4.5 1 1 4 5 5 5 4 Pentacotripeptide-repeat region of PRORP MRP-S27 PF10037.9 KOO31487.1 - 2.3e-07 30.1 0.2 0.075 11.9 0.0 3.9 2 1 3 5 5 5 2 Mitochondrial 28S ribosomal protein S27 Clathrin PF00637.20 KOO31487.1 - 2.8e-05 24.0 0.0 3 7.7 0.0 4.3 3 2 1 4 4 4 1 Region in Clathrin and VPS TPR_19 PF14559.6 KOO31487.1 - 4.9e-05 23.8 9.4 0.016 15.7 0.4 5.8 6 1 1 7 7 7 1 Tetratricopeptide repeat ATP13 PF12921.7 KOO31487.1 - 0.00056 19.8 0.0 2.9 7.8 0.0 4.8 3 3 2 5 5 5 1 Mitochondrial ATPase expression TPR_14 PF13428.6 KOO31487.1 - 0.014 16.2 11.0 26 6.0 0.5 6.9 8 0 0 8 8 6 0 Tetratricopeptide repeat Pex19 PF04614.12 KOO31487.1 - 0.021 14.6 0.1 0.32 10.7 0.1 2.5 2 1 0 2 2 2 0 Pex19 protein family COX5A PF02284.16 KOO31487.1 - 0.13 12.3 0.5 73 3.4 0.0 4.3 3 1 0 4 4 4 0 Cytochrome c oxidase subunit Va RIC1 PF07064.13 KOO31487.1 - 0.2 11.0 0.8 2.4 7.5 0.0 3.1 3 1 1 4 4 4 0 RIC1 Sda PF08970.10 KOO31487.1 - 0.28 10.9 2.5 65 3.4 0.0 4.9 6 0 0 6 6 6 0 Sporulation inhibitor A POR PF01558.18 KOO31488.1 - 0.031 14.4 0.0 0.04 14.0 0.0 1.1 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase DUF1275 PF06912.11 KOO31489.1 - 3.4e-24 85.9 10.3 4.2e-24 85.6 10.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) PMP22_Claudin PF00822.20 KOO31489.1 - 0.028 14.3 0.9 0.18 11.7 0.6 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family FAM76 PF16046.5 KOO31490.1 - 4.5 6.5 10.8 10 5.3 10.8 1.6 1 0 0 1 1 1 0 FAM76 protein DUF1499 PF07386.11 KOO31492.1 - 5.3e-12 46.3 0.3 7.2e-11 42.7 0.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1499) Beach PF02138.18 KOO31494.1 - 6.8e-90 301.2 0.0 9.2e-90 300.8 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 KOO31494.1 - 2.1e-07 31.0 0.2 2.5e-05 24.3 0.0 2.7 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH GCP_N_terminal PF17681.1 KOO31494.1 - 0.13 11.9 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Gamma tubulin complex component N-terminal RsbRD_N PF14361.6 KOO31494.1 - 0.27 11.9 2.1 1.6 9.4 0.0 3.1 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain Romo1 PF10247.9 KOO31494.1 - 0.29 11.5 1.1 0.57 10.6 1.1 1.4 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Pro_isomerase PF00160.21 KOO31495.1 - 5.6e-24 85.2 0.1 6.2e-24 85.1 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MMR_HSR1 PF01926.23 KOO31498.1 - 3.8e-06 27.0 0.0 1.2e-05 25.3 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 KOO31498.1 - 0.027 14.1 0.0 2.8 7.5 0.0 2.2 2 0 0 2 2 2 0 Ras family DUF3297 PF11730.8 KOO31498.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) FlgN PF05130.12 KOO31499.1 - 2.2e-05 25.0 6.1 2.2e-05 25.0 6.1 1.4 2 0 0 2 2 2 1 FlgN protein GHMP_kinases_C PF08544.13 KOO31499.1 - 0.0067 16.8 0.3 0.016 15.6 0.3 2.0 1 1 0 1 1 1 1 GHMP kinases C terminal Med30 PF11315.8 KOO31499.1 - 0.008 16.4 0.3 0.011 15.9 0.3 1.3 1 0 0 1 1 1 1 Mediator complex subunit 30 DUF4407 PF14362.6 KOO31499.1 - 0.086 12.2 3.8 0.11 11.8 3.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sipho_Gp157 PF05565.11 KOO31499.1 - 5.7 6.9 8.1 0.58 10.2 4.0 1.6 2 1 0 2 2 2 0 Siphovirus Gp157 DUF2058 PF09831.9 KOO31500.1 - 3.3 7.8 19.2 3.3 7.8 19.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) Rtf2 PF04641.12 KOO31500.1 - 6.8 6.0 19.6 7 5.9 19.6 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Methyltransf_25 PF13649.6 KOO31501.1 - 0.00047 20.8 0.1 0.00079 20.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO31501.1 - 0.0012 19.4 0.1 0.0021 18.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO31501.1 - 0.017 15.0 0.0 0.039 13.8 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain C2 PF00168.30 KOO31502.1 - 6e-67 222.4 0.0 1.3e-18 67.2 0.0 6.4 5 1 1 6 6 6 6 C2 domain Glyco_hydro_3_C PF01915.22 KOO31503.1 - 8.2e-34 117.3 0.0 1.6e-33 116.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOO31503.1 - 4.8e-31 108.3 0.0 7e-30 104.5 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOO31503.1 - 2.9e-06 27.3 0.0 5.8e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain CS PF04969.16 KOO31504.1 - 0.00058 20.8 0.2 0.001 20.1 0.2 1.3 1 0 0 1 1 1 1 CS domain DUF995 PF06191.12 KOO31504.1 - 0.13 11.9 0.0 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF995) Ephrin_rec_like PF07699.13 KOO31505.1 - 3.4e-28 97.2 144.1 4.1e-08 32.8 1.3 16.3 8 1 9 20 20 20 12 Putative ephrin-receptor like VCBS PF13517.6 KOO31505.1 - 7.6e-20 71.3 14.3 2.7e-12 47.1 6.2 2.6 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO31505.1 - 4.1e-13 49.2 25.5 7.2e-05 22.8 3.3 3.9 3 0 0 3 3 3 3 FG-GAP repeat Tmemb_14 PF03647.13 KOO31505.1 - 0.07 13.9 0.2 0.23 12.2 0.2 1.9 1 0 0 1 1 1 0 Transmembrane proteins 14C Dockerin_1 PF00404.18 KOO31505.1 - 0.083 13.1 2.8 20 5.5 0.1 3.3 3 0 0 3 3 3 0 Dockerin type I domain Coronavirus_5 PF05528.11 KOO31507.1 - 0.00032 20.6 5.1 0.33 10.9 0.1 4.2 2 1 2 4 4 4 2 Coronavirus gene 5 protein Peptidase_C92 PF05708.12 KOO31507.1 - 0.093 12.8 0.1 25 4.9 0.0 3.8 4 1 1 5 5 5 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family DUF282 PF03380.14 KOO31507.1 - 0.42 10.6 8.9 5.6 7.0 0.1 4.3 4 0 0 4 4 4 0 Caenorhabditis protein of unknown function, DUF282 MtrA PF04208.14 KOO31507.1 - 0.48 10.0 5.5 1.3 8.6 1.1 2.6 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit A DUF4357 PF14267.6 KOO31507.1 - 3.1 7.8 4.3 41 4.2 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) UCH PF00443.29 KOO31508.1 - 2.2e-41 142.1 0.0 3.2e-41 141.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO31508.1 - 9.4e-11 41.9 0.0 2.1e-09 37.4 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SET PF00856.28 KOO31510.1 - 0.0002 21.8 0.0 0.0012 19.3 0.0 1.9 2 0 0 2 2 2 1 SET domain Voldacs PF03517.13 KOO31510.1 - 0.05 13.7 0.0 0.075 13.2 0.0 1.3 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling TPR_16 PF13432.6 KOO31511.1 - 5.7e-16 58.9 1.3 1.7e-08 34.9 0.3 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO31511.1 - 2.5e-15 55.6 0.0 2e-06 27.8 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO31511.1 - 9.9e-15 54.0 0.1 4.8e-05 23.0 0.0 3.9 3 1 1 4 4 4 3 TPR repeat TPR_2 PF07719.17 KOO31511.1 - 1.2e-12 46.9 1.5 0.00014 21.7 0.1 4.1 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO31511.1 - 8.2e-12 44.9 1.0 8.9e-05 23.0 0.0 3.9 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO31511.1 - 1.2e-10 40.7 1.1 9.4e-05 22.1 0.1 4.4 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO31511.1 - 2.1e-09 37.8 0.2 0.0033 17.9 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31511.1 - 1.1e-08 34.5 0.0 0.00068 19.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO31511.1 - 6.8e-08 32.7 0.3 6.3e-06 26.4 0.1 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOO31511.1 - 3.1e-06 27.4 0.1 0.46 11.2 0.0 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO31511.1 - 6.7e-06 25.8 0.5 0.27 11.4 0.0 3.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO31511.1 - 3.8e-05 23.4 2.3 0.12 12.3 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO31511.1 - 0.0019 18.3 0.4 0.1 12.8 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_20 PF14561.6 KOO31511.1 - 0.023 15.0 0.0 14 6.1 0.0 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat Glyco_transf_29 PF00777.18 KOO31512.1 - 5.2e-30 104.8 0.0 8.7e-30 104.0 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Laminin_EGF PF00053.24 KOO31512.1 - 0.32 11.2 10.8 1.2 9.3 10.8 2.0 1 1 0 1 1 1 0 Laminin EGF domain EGF_Tenascin PF18720.1 KOO31512.1 - 0.83 9.8 5.6 1.8 8.7 5.6 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 KOO31512.1 - 1 9.8 20.5 0.059 13.7 12.8 2.4 2 0 0 2 2 2 0 EGF-like domain PIP5K PF01504.18 KOO31513.1 - 5.6e-46 157.0 0.0 8e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Methyltransf_28 PF02636.17 KOO31513.1 - 1.7e-21 77.1 0.0 2.8e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Chloroa_b-bind PF00504.21 KOO31514.1 - 3.2e-37 128.5 0.1 4.3e-37 128.1 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein RPAP1_C PF08620.10 KOO31515.1 - 1.9e-21 76.0 0.1 4.4e-21 74.8 0.1 1.7 1 0 0 1 1 1 1 RPAP1-like, C-terminal PIP5K PF01504.18 KOO31516.1 - 8.8e-33 113.7 0.0 2.1e-16 60.0 0.0 2.0 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase LVIVD PF08309.11 KOO31517.1 - 6.3e-50 166.2 41.7 5.8e-13 47.9 3.0 5.2 5 0 0 5 5 5 5 LVIVD repeat PSCyt3 PF07627.11 KOO31517.1 - 0.0002 21.6 0.1 19 5.6 0.0 4.8 3 2 2 5 5 5 0 Protein of unknown function (DUF1588) SBP56 PF05694.11 KOO31517.1 - 0.00022 20.2 0.0 0.26 10.1 0.0 3.6 1 1 3 4 4 4 1 56kDa selenium binding protein (SBP56) Beta_propel PF09826.9 KOO31517.1 - 0.003 16.5 0.1 5.8 5.6 0.0 3.9 2 2 1 4 4 4 2 Beta propeller domain Lactonase PF10282.9 KOO31517.1 - 0.0036 16.6 5.8 1.5 8.0 0.4 3.2 1 1 2 3 3 3 2 Lactonase, 7-bladed beta-propeller MTTB PF06253.11 KOO31517.1 - 0.013 13.6 5.8 0.069 11.1 0.4 2.4 1 1 1 2 2 2 0 Trimethylamine methyltransferase (MTTB) Chitin_bind_4 PF00379.23 KOO31517.1 - 0.17 12.5 13.0 22 5.7 0.1 4.8 5 0 0 5 5 5 0 Insect cuticle protein PQQ_3 PF13570.6 KOO31517.1 - 0.6 10.7 25.7 18 6.0 0.1 5.6 5 0 0 5 5 5 0 PQQ-like domain Kelch_6 PF13964.6 KOO31517.1 - 0.62 10.4 7.1 11 6.5 0.4 3.4 3 0 0 3 3 3 0 Kelch motif TMEM126 PF07114.11 KOO31517.1 - 2.3 7.6 9.9 7.7 5.9 0.1 4.6 2 2 4 6 6 6 0 Transmembrane protein 126 Myb_DNA-bind_7 PF15963.5 KOO31518.1 - 1.3e-22 79.5 0.0 2.3e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 KOO31518.1 - 1.5e-08 34.7 0.0 3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO31518.1 - 8.4e-05 22.7 0.0 0.00042 20.5 0.0 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain GSK-3_bind PF05350.12 KOO31518.1 - 0.004 16.5 1.3 1.3 8.3 0.1 2.7 2 0 0 2 2 2 2 Glycogen synthase kinase-3 binding DUF155 PF02582.14 KOO31519.1 - 1.5e-08 34.9 0.2 2.3e-08 34.3 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 CCDC144C PF14915.6 KOO31519.1 - 0.043 12.9 0.1 0.054 12.6 0.1 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Sel1 PF08238.12 KOO31520.1 - 2e-22 79.1 34.1 2.5e-05 24.8 0.2 9.9 10 0 0 10 10 10 5 Sel1 repeat TPR_1 PF00515.28 KOO31520.1 - 0.016 15.0 3.1 4.9 7.1 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO31520.1 - 0.018 15.7 0.2 0.018 15.7 0.2 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO31520.1 - 0.029 14.7 8.2 0.93 9.8 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO31520.1 - 0.034 14.2 7.4 0.12 12.5 0.1 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31520.1 - 0.1 12.9 3.8 0.66 10.3 0.1 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TetR_C_24 PF17932.1 KOO31520.1 - 0.1 12.8 0.4 0.24 11.7 0.4 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TPR_17 PF13431.6 KOO31520.1 - 0.11 12.9 0.3 29 5.4 0.0 4.2 2 1 1 3 3 3 0 Tetratricopeptide repeat SelB-wing_1 PF09105.10 KOO31520.1 - 0.15 12.1 1.9 1.1 9.3 0.2 2.9 2 0 0 2 2 2 0 Elongation factor SelB, winged helix TPR_14 PF13428.6 KOO31520.1 - 0.28 12.1 0.0 0.28 12.1 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO31520.1 - 0.83 9.9 0.0 0.83 9.9 0.0 5.3 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO31520.1 - 7.3 7.5 7.4 46 5.0 0.1 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Cyclin PF08613.11 KOO31521.1 - 6.4e-07 29.9 0.0 9.8e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KOO31521.1 - 1.3e-05 25.0 0.0 2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain FANCA_interact PF15751.5 KOO31521.1 - 0.017 15.6 0.5 0.06 13.8 0.5 2.0 1 0 0 1 1 1 0 FAAP20 FANCA interaction domain ABC1 PF03109.16 KOO31522.1 - 3e-29 101.6 0.0 6.7e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO31522.1 - 0.00026 21.0 0.7 0.00077 19.5 0.4 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO31522.1 - 0.055 12.8 0.0 0.15 11.4 0.0 1.8 2 1 0 2 2 2 0 Protein kinase domain ADK PF00406.22 KOO31523.1 - 9.7e-37 126.4 0.0 1.3e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO31523.1 - 5.4e-22 78.7 0.0 7e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO31523.1 - 1.3e-10 42.0 0.0 2.2e-10 41.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO31523.1 - 1.4e-05 25.2 0.2 8.6e-05 22.7 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO31523.1 - 0.0033 17.8 0.0 0.0034 17.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOO31523.1 - 0.004 17.4 0.1 0.032 14.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 KOO31523.1 - 0.011 15.6 0.0 0.18 11.6 0.0 2.0 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_22 PF13401.6 KOO31523.1 - 0.026 14.8 0.1 0.068 13.5 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO31523.1 - 0.044 14.2 0.1 0.072 13.5 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Thymidylate_kin PF02223.17 KOO31523.1 - 0.062 13.0 0.0 7 6.3 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase Ploopntkinase3 PF18751.1 KOO31523.1 - 0.075 12.9 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 EF-hand_1 PF00036.32 KOO31524.1 - 5.1e-16 57.0 0.4 7.7e-06 25.1 0.5 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO31524.1 - 3.5e-14 53.0 0.1 2.1e-09 37.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO31524.1 - 1.1e-13 49.9 0.1 0.004 17.0 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KOO31524.1 - 1.2e-13 50.7 0.2 2.9e-08 33.4 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO31524.1 - 2.3e-07 30.0 2.0 0.0054 16.2 0.2 3.2 3 0 0 3 3 3 2 EF hand Voltage_CLC PF00654.20 KOO31525.1 - 6.3e-61 206.6 24.5 3.7e-60 204.1 24.5 2.2 1 1 0 1 1 1 1 Voltage gated chloride channel CBM_1 PF00734.18 KOO31525.1 - 1.6e-09 37.5 24.5 1.4e-06 28.1 1.9 3.3 3 0 0 3 3 3 2 Fungal cellulose binding domain SMC_N PF02463.19 KOO31526.1 - 1.5e-62 211.0 0.0 2.2e-62 210.3 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOO31526.1 - 7e-19 68.3 0.6 2e-18 66.8 0.0 2.2 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KOO31526.1 - 6.2e-12 45.9 2.7 1.4e-05 25.0 0.0 2.8 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KOO31526.1 - 1.9e-10 41.6 0.0 1.9e-10 41.6 0.0 6.2 3 2 1 4 4 4 1 AAA domain AAA_15 PF13175.6 KOO31526.1 - 0.00015 21.6 0.1 0.00015 21.6 0.1 2.9 3 0 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 KOO31526.1 - 0.002 17.8 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DNA_Packaging_2 PF11123.8 KOO31526.1 - 0.0065 16.7 0.1 0.022 14.9 0.1 1.9 1 0 0 1 1 1 1 DNA packaging protein FlaC_arch PF05377.11 KOO31526.1 - 0.065 13.6 12.0 0.063 13.7 0.5 5.4 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) ABC_tran PF00005.27 KOO31526.1 - 0.55 10.8 12.3 3.6 8.1 0.1 5.4 4 2 0 4 4 4 0 ABC transporter DnaJ PF00226.31 KOO31527.1 - 4.3e-22 78.0 0.1 6.4e-22 77.4 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.9 KOO31527.1 - 3.4e-14 53.2 14.7 3.4e-14 53.2 14.7 2.0 1 1 1 2 2 2 1 Transmembrane Fragile-X-F protein DUF423 PF04241.15 KOO31527.1 - 0.3 11.3 3.7 0.39 11.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF423) Pox_A12 PF04651.13 KOO31528.1 - 0.42 10.6 3.8 0.67 10.0 3.8 1.4 1 0 0 1 1 1 0 Poxvirus A12 protein IQ PF00612.27 KOO31530.1 - 0.037 13.8 1.0 0.1 12.5 1.0 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif ORF6C PF10552.9 KOO31532.1 - 0.22 11.6 4.0 2.7 8.1 0.0 2.9 2 1 1 3 3 3 0 ORF6C domain Spc7 PF08317.11 KOO31532.1 - 0.56 9.0 17.7 0.17 10.7 9.3 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 KOO31532.1 - 1.9 7.8 18.7 1.2 8.5 6.4 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding SOGA PF11365.8 KOO31532.1 - 4.8 8.4 14.2 71 4.6 3.3 3.0 1 1 1 2 2 2 0 Protein SOGA TPR_MLP1_2 PF07926.12 KOO31532.1 - 7.8 6.6 23.3 14 5.7 0.2 3.2 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein GrpE PF01025.19 KOO31532.1 - 8.1 6.1 16.7 3.7 7.2 7.8 2.8 1 1 1 2 2 2 0 GrpE ADIP PF11559.8 KOO31532.1 - 10 6.2 17.1 1.3 9.1 5.1 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Ion_trans PF00520.31 KOO31533.1 - 3.3e-202 668.4 52.3 4.4e-56 189.8 2.1 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO31533.1 - 6.2e-25 87.8 47.3 1.2e-10 40.7 0.4 9.2 7 3 2 9 9 9 7 Polycystin cation channel GPHH PF16905.5 KOO31533.1 - 1.2e-06 28.2 0.0 3.1e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated 2OG-FeII_Oxy_3 PF13640.6 KOO31533.1 - 2.3e-05 25.2 0.0 4.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_1 PF00036.32 KOO31534.1 - 5.9e-36 119.3 4.0 0.00011 21.5 0.1 6.5 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO31534.1 - 9.5e-34 112.4 1.7 0.00062 19.5 0.0 6.6 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.6 KOO31534.1 - 5e-30 103.8 0.7 4.8e-07 30.1 0.5 5.8 6 0 0 6 6 6 5 EF-hand domain pair EF-hand_8 PF13833.6 KOO31534.1 - 4.8e-22 77.6 7.2 1.3e-07 31.4 0.1 5.1 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO31534.1 - 1.7e-21 74.7 16.4 0.0016 17.9 0.1 6.8 6 0 0 6 6 6 6 EF hand Caleosin PF05042.13 KOO31534.1 - 5.6e-05 23.1 0.3 9 6.2 0.0 5.0 3 3 2 5 5 5 2 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO31534.1 - 0.0075 16.6 1.6 4.4 7.7 0.0 4.1 3 1 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region NOA36 PF06524.12 KOO31534.1 - 0.69 9.2 2.8 17 4.6 2.6 2.3 2 0 0 2 2 2 0 NOA36 protein Band_7 PF01145.25 KOO31535.1 - 0.0037 17.3 1.6 0.008 16.2 0.1 1.9 1 1 1 2 2 2 1 SPFH domain / Band 7 family FAD_binding_7 PF03441.14 KOO31536.1 - 1.5e-79 266.2 2.1 2.3e-79 265.6 2.1 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KOO31536.1 - 0.0054 16.8 0.0 0.03 14.3 0.0 2.2 3 0 0 3 3 3 1 DNA photolyase Cpn60_TCP1 PF00118.24 KOO31537.1 - 5.4e-156 520.0 3.7 6.2e-156 519.9 3.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PC-Esterase PF13839.6 KOO31538.1 - 0.038 13.7 0.0 0.085 12.6 0.0 1.6 1 0 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Heme_oxygenase PF01126.20 KOO31539.1 - 3.3e-10 40.1 0.1 3.8e-10 39.9 0.1 1.1 1 0 0 1 1 1 1 Heme oxygenase VCBS PF13517.6 KOO31541.1 - 2.8e-31 107.9 26.8 1.1e-13 51.5 5.7 3.4 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO31541.1 - 3.7e-15 55.7 22.8 1.2e-05 25.3 1.2 3.4 3 0 0 3 3 3 3 FG-GAP repeat Dockerin_1 PF00404.18 KOO31541.1 - 0.00052 20.2 3.2 6.7 7.0 0.0 3.3 3 0 0 3 3 3 3 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO31541.1 - 0.0012 18.3 8.3 0.14 11.5 0.0 3.1 2 1 1 3 3 3 2 Insecticide toxin TcdB middle/N-terminal region EF-hand_1 PF00036.32 KOO31541.1 - 0.0044 16.5 5.4 5.8 6.7 0.1 3.3 3 0 0 3 3 3 3 EF hand Asp-B-Hydro_N PF05279.11 KOO31541.1 - 0.023 14.8 3.9 20 5.2 0.1 3.2 3 0 0 3 3 3 0 Aspartyl beta-hydroxylase N-terminal region EF-hand_5 PF13202.6 KOO31541.1 - 0.054 13.0 13.2 4.2 7.0 0.5 3.3 3 0 0 3 3 3 0 EF hand BBS1 PF14779.6 KOO31541.1 - 0.14 11.6 0.1 28 4.1 0.0 2.8 2 1 0 3 3 3 0 Ciliary BBSome complex subunit 1 DUF2530 PF10745.9 KOO31541.1 - 1.6 9.1 5.3 15 5.9 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Nop52 PF05997.12 KOO31542.1 - 5.4e-55 186.5 0.1 1.1e-54 185.6 0.0 1.5 2 0 0 2 2 2 1 Nucleolar protein,Nop52 CENP-B_dimeris PF09026.10 KOO31542.1 - 0.00047 20.5 14.7 0.00058 20.2 13.3 1.8 2 0 0 2 2 2 1 Centromere protein B dimerisation domain HEAT_2 PF13646.6 KOO31542.1 - 0.0022 18.4 0.2 0.0086 16.4 0.0 2.1 2 0 0 2 2 2 1 HEAT repeats Sigma70_ner PF04546.13 KOO31542.1 - 0.0093 15.9 5.3 0.016 15.1 5.3 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region RXT2_N PF08595.11 KOO31542.1 - 0.02 15.0 1.3 0.031 14.3 1.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4611 PF15387.6 KOO31542.1 - 0.025 14.8 4.8 0.06 13.6 4.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Cwf_Cwc_15 PF04889.12 KOO31542.1 - 0.032 14.0 6.6 0.052 13.3 6.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 KOO31542.1 - 0.039 14.3 7.6 0.092 13.1 7.6 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4217 PF13959.6 KOO31542.1 - 0.049 13.9 0.1 0.097 12.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4217) HEAT_EZ PF13513.6 KOO31542.1 - 0.061 13.8 0.1 0.32 11.5 0.0 2.2 2 0 0 2 2 2 0 HEAT-like repeat DNA_pol_phi PF04931.13 KOO31542.1 - 0.069 11.3 8.9 0.11 10.5 8.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi Rhabdo_ncap PF00945.18 KOO31542.1 - 0.087 11.7 0.9 0.12 11.2 0.9 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein FAM176 PF14851.6 KOO31542.1 - 0.27 10.9 4.5 0.051 13.2 1.0 1.5 2 0 0 2 2 2 0 FAM176 family NOA36 PF06524.12 KOO31542.1 - 0.69 9.2 10.2 1.1 8.5 10.2 1.3 1 0 0 1 1 1 0 NOA36 protein Importin_rep_6 PF18829.1 KOO31542.1 - 4.5 7.5 6.7 16 5.7 0.0 2.4 2 0 0 2 2 2 0 Importin repeat 6 S-antigen PF05756.11 KOO31542.1 - 9.7 6.6 6.5 17 5.9 6.5 1.3 1 0 0 1 1 1 0 S-antigen protein Sod_Cu PF00080.20 KOO31544.1 - 4.6e-43 146.8 0.9 7.7e-43 146.1 0.9 1.4 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) BASP1 PF05466.12 KOO31544.1 - 7.4 6.5 15.0 2.2 8.3 0.8 2.1 2 0 0 2 2 2 0 Brain acid soluble protein 1 (BASP1 protein) RhoGEF PF00621.20 KOO31546.1 - 9.3e-24 84.7 0.0 2.6e-23 83.2 0.0 1.7 2 0 0 2 2 2 1 RhoGEF domain Ras PF00071.22 KOO31547.1 - 1.2e-20 73.7 0.0 2.4e-17 63.0 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 KOO31547.1 - 5.8e-12 45.9 0.0 4.2e-07 30.2 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_1 PF00036.32 KOO31547.1 - 1.2e-11 43.3 1.0 1.3e-05 24.4 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31547.1 - 2.8e-11 42.4 1.6 1e-05 25.0 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO31547.1 - 1.3e-10 41.6 0.2 2.8e-10 40.5 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO31547.1 - 1.2e-07 31.5 0.0 3.2e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO31547.1 - 1.3e-06 27.6 1.4 0.017 14.6 0.2 2.7 2 0 0 2 2 2 2 EF hand MMR_HSR1 PF01926.23 KOO31547.1 - 0.00057 20.0 0.0 0.88 9.7 0.2 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase ABC_tran PF00005.27 KOO31547.1 - 0.0014 19.1 0.2 0.0035 17.9 0.2 1.6 1 0 0 1 1 1 1 ABC transporter Arf PF00025.21 KOO31547.1 - 0.0082 15.6 0.0 1.7 8.0 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KOO31547.1 - 0.017 15.1 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 KOO31547.1 - 0.034 14.5 0.1 0.1 13.0 0.1 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 KOO31547.1 - 0.046 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 KOO31547.1 - 0.063 13.8 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 KOO31547.1 - 0.14 11.6 0.0 6.7 6.1 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 KOO31547.1 - 0.16 11.6 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOO31547.1 - 0.2 11.9 0.2 0.42 10.8 0.2 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KOO31547.1 - 0.21 11.2 0.3 0.43 10.1 0.2 1.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Redoxin PF08534.10 KOO31548.1 - 7.6e-15 54.9 0.4 6.1e-14 52.0 0.4 1.9 1 1 0 1 1 1 1 Redoxin Glyco_transf_10 PF00852.19 KOO31549.1 - 1.1e-28 100.1 0.0 1.7e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term EF-hand_6 PF13405.6 KOO31550.1 - 2.5e-10 39.4 0.0 5.6e-05 22.7 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO31550.1 - 1.6e-09 36.7 0.1 0.00079 18.8 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO31550.1 - 3.7e-08 32.5 0.9 0.009 15.5 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO31550.1 - 1.2e-07 32.1 0.1 4.1e-05 23.9 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO31550.1 - 0.011 15.5 0.2 0.21 11.5 0.0 2.6 2 1 0 2 2 2 0 EF-hand domain pair NHL PF01436.21 KOO31551.1 - 2.3e-06 27.4 0.4 0.16 12.1 0.0 5.9 6 0 0 6 6 6 2 NHL repeat F-box-like PF12937.7 KOO31552.1 - 7.3e-09 35.4 0.3 1.6e-08 34.3 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOO31552.1 - 0.00034 20.4 0.0 0.001 18.9 0.0 1.7 1 0 0 1 1 1 1 F-box domain PDZ_6 PF17820.1 KOO31553.1 - 0.12 12.2 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Glyoxalase_6 PF18029.1 KOO31554.1 - 0.017 15.9 1.5 0.73 10.6 0.1 2.8 2 1 0 2 2 2 0 Glyoxalase-like domain SLC12 PF03522.15 KOO31555.1 - 1.8 7.5 4.6 1.7 7.6 0.0 2.7 1 1 0 2 2 2 0 Solute carrier family 12 TFIIA PF03153.13 KOO31555.1 - 4.5 7.2 6.9 6.4 6.7 6.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPR_2 PF07719.17 KOO31556.1 - 3.1e-24 83.1 23.3 2.3e-06 27.3 0.1 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 KOO31556.1 - 2e-17 62.2 14.1 3.2e-06 26.7 0.0 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOO31556.1 - 7.3e-14 51.2 19.3 0.0059 16.3 0.0 6.8 4 2 2 6 6 6 6 TPR repeat TPR_16 PF13432.6 KOO31556.1 - 1e-12 48.5 41.5 1.2e-06 29.0 3.8 6.3 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO31556.1 - 4.9e-08 33.4 24.3 9.3e-05 22.9 1.6 5.0 2 2 4 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO31556.1 - 1e-07 32.2 33.0 0.0087 16.8 0.3 7.2 3 2 4 7 7 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31556.1 - 2.3e-07 30.5 7.1 0.014 15.5 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO31556.1 - 5.3e-07 29.7 7.7 0.00029 20.9 0.7 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 KOO31556.1 - 2.3e-06 27.7 24.2 0.13 13.0 0.4 6.7 5 2 0 5 5 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO31556.1 - 5.5e-06 26.4 2.2 0.19 12.2 0.0 3.5 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO31556.1 - 2.5e-05 24.6 16.6 0.81 10.5 0.1 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO31556.1 - 2.7e-05 24.3 6.9 0.068 13.4 0.4 3.2 2 2 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KOO31556.1 - 3.1e-05 24.2 21.7 0.34 11.2 1.1 5.1 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_21 PF09976.9 KOO31556.1 - 0.00018 21.3 23.0 0.037 13.7 7.5 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat-like domain NARP1 PF12569.8 KOO31556.1 - 0.0012 17.9 0.2 1.4 7.7 0.0 2.4 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 KOO31556.1 - 0.0083 16.0 18.1 7.7 6.5 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat NYD-SP12_N PF15015.6 KOO31556.1 - 0.0086 14.5 2.1 1.4 7.2 0.2 2.1 2 0 0 2 2 2 2 Spermatogenesis-associated, N-terminal TPR_7 PF13176.6 KOO31556.1 - 0.022 14.8 6.5 70 3.8 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.17 KOO31556.1 - 0.45 11.0 25.1 3.2 8.2 6.2 4.3 3 2 0 3 3 3 0 Bacterial transcriptional activator domain TPR_15 PF13429.6 KOO31556.1 - 1.6 7.9 13.4 1.9 7.7 0.5 3.4 2 2 2 4 4 4 0 Tetratricopeptide repeat GAS PF13851.6 KOO31558.1 - 6.7e-84 280.2 27.1 6.7e-84 280.2 27.1 2.8 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 KOO31558.1 - 0.014 13.0 66.3 0.69 7.3 47.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) E6 PF00518.17 KOO31558.1 - 1.8 9.0 6.1 8.1 6.9 6.1 2.2 1 0 0 1 1 1 0 Early Protein (E6) TPR_1 PF00515.28 KOO31559.1 - 1.8e-07 30.7 3.3 0.011 15.6 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO31559.1 - 2.2e-06 27.3 2.5 0.1 12.8 0.3 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31559.1 - 5.7e-05 23.0 1.6 0.18 12.1 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO31559.1 - 0.00016 21.9 0.5 0.96 10.0 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO31559.1 - 0.00019 21.0 1.4 0.0016 18.1 0.2 2.4 1 1 1 2 2 2 1 TPR repeat TPR_16 PF13432.6 KOO31559.1 - 0.0024 18.5 0.5 0.012 16.2 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat CAF1A PF12253.8 KOO31560.1 - 0.034 14.3 4.9 0.043 14.0 4.9 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Astro_capsid_p PF12226.8 KOO31560.1 - 0.34 10.0 5.4 0.36 9.9 5.4 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein AAA_11 PF13086.6 KOO31561.1 - 5.9e-19 68.9 0.2 2.6e-08 34.0 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_12 PF13087.6 KOO31561.1 - 1.6e-16 60.5 0.0 2.7e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KOO31561.1 - 0.0012 18.7 1.5 0.17 11.7 0.9 3.4 3 1 0 3 3 3 1 UvrD-like helicase C-terminal domain PhyH PF05721.13 KOO31562.1 - 4.1e-14 53.3 0.2 7.4e-14 52.5 0.2 1.5 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 KOO31562.1 - 0.019 15.4 0.3 1.4 9.4 0.0 2.3 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase Aldo_ket_red PF00248.21 KOO31565.1 - 5.5e-15 55.3 0.0 2.7e-13 49.8 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family Galactosyl_T PF01762.21 KOO31566.1 - 7e-06 26.0 0.0 1.2e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Galactosyltransferase EF-hand_1 PF00036.32 KOO31567.1 - 4.2e-29 97.9 0.8 4e-05 22.8 0.0 6.5 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO31567.1 - 2.4e-28 98.4 6.0 1.4e-08 35.1 0.1 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO31567.1 - 6.6e-26 88.0 3.6 9.1e-05 22.1 0.0 6.7 7 0 0 7 7 7 6 EF-hand domain EF-hand_5 PF13202.6 KOO31567.1 - 3.2e-17 61.1 6.0 0.00058 19.2 0.0 6.5 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO31567.1 - 5.4e-15 55.0 8.1 0.03 14.2 0.0 6.3 5 1 1 6 6 6 4 EF-hand domain pair zf-C2HC_2 PF13913.6 KOO31567.1 - 1.3e-08 34.6 16.4 6.2e-07 29.2 4.2 3.0 3 0 0 3 3 3 2 zinc-finger of a C2HC-type EF-hand_4 PF12763.7 KOO31567.1 - 7.8e-05 22.6 0.7 1.6 8.8 0.0 3.6 1 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO31567.1 - 0.00023 21.5 7.9 0.35 11.2 0.1 4.5 3 2 2 5 5 5 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO31567.1 - 0.00096 19.3 0.0 0.024 14.8 0.0 2.3 1 1 1 2 2 2 2 Dockerin type I domain DUF3486 PF11985.8 KOO31567.1 - 0.0011 19.4 5.0 0.016 15.6 3.7 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3486) EF-hand_9 PF14658.6 KOO31567.1 - 0.038 14.3 0.1 0.62 10.4 0.0 2.8 3 1 1 4 4 4 0 EF-hand domain Gp-FAR-1 PF05823.12 KOO31567.1 - 0.054 13.8 0.2 0.27 11.6 0.0 2.1 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) CCDC154 PF15450.6 KOO31567.1 - 0.071 11.7 3.4 0.13 10.8 3.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 154 zf_Rg PF17915.1 KOO31567.1 - 0.24 10.8 8.9 3.1 7.3 0.3 4.4 4 0 0 4 4 4 0 Reverse gyrase zinc finger Myb_DNA-bind_7 PF15963.5 KOO31567.1 - 0.86 9.5 3.9 21 5.1 0.2 3.1 3 0 0 3 3 3 0 Myb DNA-binding like TarH PF02203.15 KOO31567.1 - 3.1 7.7 7.8 7.1 6.5 7.8 1.5 1 0 0 1 1 1 0 Tar ligand binding domain homologue zf-NADH-PPase PF09297.11 KOO31567.1 - 5 6.9 7.3 18 5.1 1.1 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain OEP PF02321.18 KOO31567.1 - 8.5 6.1 13.1 13 5.6 13.1 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein DAO PF01266.24 KOO31568.1 - 1.5e-47 162.9 4.5 1.8e-47 162.6 4.5 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOO31568.1 - 0.00061 20.0 1.1 0.0014 18.8 1.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 KOO31568.1 - 0.00084 18.7 0.1 0.0063 15.8 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Trypsin_2 PF13365.6 KOO31569.1 - 1.4e-20 74.7 1.6 2.8e-20 73.7 1.6 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 KOO31569.1 - 7.1e-11 42.3 0.1 9.7e-11 41.9 0.1 1.2 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 KOO31569.1 - 3.3e-05 24.1 0.0 0.00041 20.6 0.0 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_3 PF17815.1 KOO31569.1 - 0.00013 21.9 0.4 0.00019 21.3 0.4 1.3 1 0 0 1 1 1 1 PDZ domain Peptidase_S46 PF10459.9 KOO31569.1 - 0.012 14.3 0.1 0.016 13.8 0.1 1.1 1 0 0 1 1 1 0 Peptidase S46 Phosphoesterase PF04185.14 KOO31571.1 - 3.6e-55 187.6 0.1 5.5e-55 187.0 0.1 1.1 1 0 0 1 1 1 1 Phosphoesterase family DUF3119 PF11317.8 KOO31572.1 - 2.5e-24 85.9 0.0 4.7e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3119) IMP2_N PF18590.1 KOO31573.1 - 1.4e-13 51.2 0.0 2.8e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain MIF4G_like_2 PF09090.11 KOO31573.1 - 0.77 9.2 6.9 0.19 11.2 0.3 2.3 2 0 0 2 2 2 0 MIF4G like RabGAP-TBC PF00566.18 KOO31575.1 - 7.1e-18 65.1 0.0 9.8e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain AAA PF00004.29 KOO31577.1 - 1.2e-36 126.0 0.0 2.1e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO31577.1 - 5e-07 29.4 0.7 1.7e-06 27.7 0.4 2.0 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 KOO31577.1 - 1e-05 25.5 0.0 2.8e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO31577.1 - 1.6e-05 25.4 0.0 6e-05 23.5 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 KOO31577.1 - 6.6e-05 23.1 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOO31577.1 - 0.00046 20.5 0.1 0.011 16.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KOO31577.1 - 0.0021 17.8 0.0 0.0049 16.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 KOO31577.1 - 0.0061 16.0 0.1 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KOO31577.1 - 0.0082 16.5 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 KOO31577.1 - 0.019 14.5 0.3 0.083 12.5 0.3 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO31577.1 - 0.028 14.3 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 KOO31577.1 - 0.036 14.1 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KOO31577.1 - 0.059 13.6 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KOO31577.1 - 0.067 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain TIP49 PF06068.13 KOO31577.1 - 0.07 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_33 PF13671.6 KOO31577.1 - 0.088 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOO31577.1 - 0.092 13.3 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KOO31577.1 - 0.099 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 KOO31577.1 - 0.12 12.0 0.0 0.25 11.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 KOO31577.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MFS_1 PF07690.16 KOO31578.1 - 1.4e-24 86.7 43.4 1.4e-15 57.0 23.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO31578.1 - 7.2e-24 84.5 16.9 2e-23 83.0 16.9 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter PAE PF03283.13 KOO31579.1 - 7.2e-59 199.7 0.0 1.1e-58 199.1 0.0 1.2 1 0 0 1 1 1 1 Pectinacetylesterase SAS4 PF15460.6 KOO31580.1 - 0.019 15.0 0.0 0.024 14.7 0.0 1.2 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 Ank_5 PF13857.6 KOO31581.1 - 2.3e-09 37.3 0.0 3.9e-08 33.4 0.1 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO31581.1 - 4.3e-09 36.7 0.3 3.2e-06 27.6 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO31581.1 - 6.2e-08 33.1 0.0 5.4e-07 30.1 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO31581.1 - 6.1e-06 26.4 0.0 0.00038 20.8 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 KOO31581.1 - 2.5e-05 24.3 0.0 0.00015 21.9 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat DEAD PF00270.29 KOO31582.1 - 8.1e-43 146.2 0.0 1.3e-42 145.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO31582.1 - 1.1e-26 93.4 0.0 2.6e-26 92.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO31582.1 - 0.00016 21.8 0.0 0.00025 21.1 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_S28 PF05577.12 KOO31584.1 - 2.1e-39 135.6 0.0 1.6e-32 112.9 0.0 2.5 2 1 0 2 2 2 2 Serine carboxypeptidase S28 Trypan_PARP PF05887.11 KOO31584.1 - 3.9e-06 26.9 5.6 8.2e-06 25.8 5.6 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Peptidase_S37 PF05576.11 KOO31584.1 - 9.9e-05 21.2 0.0 0.00044 19.0 0.0 1.8 1 1 0 1 1 1 1 PS-10 peptidase S37 Hydrolase_4 PF12146.8 KOO31584.1 - 0.00014 21.2 0.1 0.00028 20.2 0.1 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO31584.1 - 0.0027 17.4 0.0 0.0047 16.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOO31584.1 - 0.013 16.1 3.6 0.035 14.7 3.2 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOO31584.1 - 0.035 13.6 0.2 0.058 12.9 0.2 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF2920 PF11144.8 KOO31584.1 - 0.21 10.7 0.0 0.31 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Ank_2 PF12796.7 KOO31586.1 - 2.3e-23 82.6 0.1 1e-14 54.9 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO31586.1 - 3.4e-12 46.2 1.0 0.00034 20.9 0.0 4.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KOO31586.1 - 3.5e-12 46.3 2.1 4e-08 33.4 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO31586.1 - 4.1e-11 42.1 1.3 0.00013 22.1 0.0 4.5 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 KOO31586.1 - 9.2e-11 42.1 0.0 1e-05 26.0 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Glyoxalase_6 PF18029.1 KOO31586.1 - 0.073 13.9 0.0 0.2 12.5 0.0 1.7 1 0 0 1 1 1 0 Glyoxalase-like domain Atx10homo_assoc PF09759.9 KOO31587.1 - 0.00018 21.5 2.1 1.1 9.4 0.0 3.5 3 0 0 3 3 3 2 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 KOO31587.1 - 0.0004 20.3 0.1 0.0036 17.3 0.1 2.6 2 1 0 2 2 2 1 Armadillo/beta-catenin-like repeat SDA1 PF05285.12 KOO31587.1 - 0.0047 16.4 19.7 0.0047 16.4 19.7 2.7 2 1 0 2 2 2 1 SDA1 F-box PF00646.33 KOO31588.1 - 0.0013 18.6 0.1 0.0055 16.6 0.1 2.0 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 KOO31588.1 - 0.019 15.4 2.0 11 6.6 0.1 4.1 3 1 3 6 6 6 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO31588.1 - 0.73 10.6 4.6 3.8e+02 2.3 1.4 5.3 3 1 0 3 3 3 0 Leucine Rich Repeat DUF812 PF05667.11 KOO31589.1 - 1.8e-97 327.7 15.5 2.9e-58 198.2 19.9 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF812) T7SS_ESX_EspC PF10824.8 KOO31589.1 - 0.67 10.5 0.1 0.67 10.5 0.1 4.5 4 2 1 5 5 5 0 Excreted virulence factor EspC, type VII ESX diderm DUF1664 PF07889.12 KOO31589.1 - 9.7 6.3 20.3 3 7.9 1.4 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Abhydrolase_6 PF12697.7 KOO31590.1 - 1.4e-07 32.4 0.1 2.3e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO31590.1 - 9.9e-06 25.0 0.0 1.4e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 KOO31590.1 - 2.1e-05 24.5 0.0 3.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOO31590.1 - 0.00071 19.1 0.1 0.0011 18.5 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF818 PF05677.12 KOO31590.1 - 0.011 14.8 0.0 0.014 14.4 0.0 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Abhydrolase_1 PF00561.20 KOO31590.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 KOO31590.1 - 0.019 13.6 0.0 0.054 12.2 0.1 1.6 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) Lipase_3 PF01764.25 KOO31590.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.5 1 1 0 1 1 1 0 Lipase (class 3) CRAL_TRIO PF00650.20 KOO31591.1 - 4.3e-16 59.0 0.0 5.6e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain PARP PF00644.20 KOO31592.1 - 9.8e-13 48.1 0.0 1.6e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain TIR_2 PF13676.6 KOO31592.1 - 3.9e-08 33.9 0.0 8.2e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 TIR domain Ank_2 PF12796.7 KOO31592.1 - 7.3e-06 26.5 0.0 1.5e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO31592.1 - 0.00081 19.9 0.0 0.0059 17.2 0.0 2.4 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO31592.1 - 0.057 13.9 0.7 0.18 12.3 0.1 2.2 2 0 0 2 2 2 0 Ankyrin repeat DNA_methylase PF00145.17 KOO31593.1 - 1.5e-12 47.5 0.0 3.2e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase SNF2_N PF00176.23 KOO31595.1 - 1.2e-19 70.2 0.0 4.8e-19 68.3 0.0 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 KOO31595.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit MutS_V PF00488.21 KOO31597.1 - 2.5e-18 66.8 0.0 4.3e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 MutS domain V AAA_21 PF13304.6 KOO31597.1 - 0.0032 17.3 0.0 0.29 10.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 KOO31597.1 - 0.074 13.3 0.1 0.37 11.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO31597.1 - 0.18 11.6 1.5 0.24 11.1 0.2 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain EF-hand_1 PF00036.32 KOO31598.1 - 1.7e-23 80.3 1.0 1.9e-05 23.9 0.0 5.5 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 KOO31598.1 - 3.4e-21 73.3 1.6 0.0019 18.0 0.0 5.7 5 0 0 5 5 5 5 EF-hand domain EF-hand_7 PF13499.6 KOO31598.1 - 2.5e-19 69.5 1.6 6.8e-09 36.0 0.0 4.6 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO31598.1 - 2.3e-14 52.1 7.7 8.5e-05 21.9 0.0 5.1 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO31598.1 - 6.2e-13 48.4 1.5 0.007 16.2 0.0 4.7 4 1 1 5 5 5 3 EF-hand domain pair Dockerin_1 PF00404.18 KOO31598.1 - 0.0025 18.0 0.0 0.46 10.7 0.0 3.3 3 0 0 3 3 3 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KOO31598.1 - 0.036 14.4 0.0 12 6.2 0.0 3.6 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO31598.1 - 0.18 12.2 0.0 1.4 9.3 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain DprA_WH PF17782.1 KOO31598.1 - 1.7 8.8 9.3 0.57 10.3 2.7 3.4 2 0 0 2 2 2 0 DprA winged helix domain DUF155 PF02582.14 KOO31600.1 - 5e-41 140.7 0.0 7.8e-41 140.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 EF-hand_1 PF00036.32 KOO31600.1 - 2.1e-12 45.7 1.7 8.2e-06 25.0 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31600.1 - 6.6e-12 44.3 2.4 6.7e-05 22.5 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO31600.1 - 8.5e-12 44.0 3.7 7e-05 22.1 0.8 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO31600.1 - 3.3e-09 37.1 0.7 1.1e-08 35.5 0.7 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO31600.1 - 1.1e-08 34.8 1.0 2.7e-08 33.5 1.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.7 KOO31600.1 - 0.034 14.1 1.3 0.13 12.2 0.2 2.3 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO31600.1 - 0.13 12.6 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region LRR_5 PF13306.6 KOO31602.1 - 1.1e-05 25.3 0.0 1.8e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Ank_2 PF12796.7 KOO31602.1 - 3.8e-05 24.2 0.0 9.8e-05 22.9 0.0 1.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO31602.1 - 0.00045 20.5 0.1 1.7 9.2 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KOO31602.1 - 0.0033 17.7 0.1 0.032 14.5 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO31602.1 - 0.0056 17.1 0.0 1.1 10.0 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 KOO31602.1 - 0.014 16.0 0.0 0.048 14.3 0.0 1.9 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Pyr_redox_2 PF07992.14 KOO31603.1 - 1.6e-07 30.9 0.0 8.2e-07 28.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO31603.1 - 2e-07 31.4 0.0 1.3e-06 28.9 0.0 2.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOO31603.1 - 0.0018 17.0 0.9 0.0037 16.0 0.0 1.9 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 KOO31603.1 - 0.0025 17.1 0.0 0.0057 16.0 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOO31603.1 - 0.0062 16.7 0.1 0.016 15.4 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO31603.1 - 0.045 13.3 0.1 0.045 13.3 0.1 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 KOO31603.1 - 0.19 12.2 0.0 0.19 12.2 0.0 2.9 2 1 0 2 2 2 0 Putative NAD(P)-binding ESP PF16590.5 KOO31603.1 - 1.3 9.4 3.0 2.7 8.3 1.1 2.5 2 0 0 2 2 2 0 Exocrine gland-secreting peptide IFT20 PF14931.6 KOO31603.1 - 4.3 7.5 10.1 4.2 7.6 7.0 2.5 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 UPF0020 PF01170.18 KOO31605.1 - 1.4e-30 106.5 0.0 1.9e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 SAP PF02037.27 KOO31605.1 - 1.7e-12 46.8 0.0 3.5e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 SAP domain THUMP PF02926.17 KOO31605.1 - 0.019 15.1 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 THUMP domain TIG PF01833.24 KOO31606.1 - 1e-15 57.5 9.1 5.2e-13 48.9 0.3 4.6 5 0 0 5 5 5 2 IPT/TIG domain PA14 PF07691.12 KOO31606.1 - 1.7e-05 24.7 0.0 0.0019 18.0 0.0 2.3 2 0 0 2 2 2 2 PA14 domain AAA_28 PF13521.6 KOO31607.1 - 3.5e-07 30.6 0.0 5.8e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain BPL_N PF09825.9 KOO31607.1 - 0.11 11.6 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal TPR_12 PF13424.6 KOO31608.1 - 5.1e-32 110.0 11.2 4.4e-13 49.3 1.9 4.9 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO31608.1 - 7e-27 92.5 24.4 1.9e-06 27.5 0.9 8.4 7 1 0 7 7 7 5 Tetratricopeptide repeat NACHT PF05729.12 KOO31608.1 - 1.7e-09 37.8 0.0 4.9e-09 36.3 0.0 1.7 2 0 0 2 2 1 1 NACHT domain AAA_16 PF13191.6 KOO31608.1 - 1.7e-08 35.1 2.4 1.8e-08 35.0 0.4 2.1 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 KOO31608.1 - 2.8e-07 30.0 0.0 5.5e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TPR_MalT PF17874.1 KOO31608.1 - 4.7e-06 26.2 0.7 3.8e-05 23.2 0.4 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_8 PF13181.6 KOO31608.1 - 1.3e-05 25.0 11.3 0.043 14.0 0.0 5.0 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO31608.1 - 9.9e-05 22.1 15.6 0.014 15.4 0.1 5.5 7 0 0 7 7 5 2 Tetratricopeptide repeat CHAT PF12770.7 KOO31608.1 - 0.00023 20.7 0.1 0.00048 19.6 0.1 1.6 1 0 0 1 1 1 1 CHAT domain TPR_1 PF00515.28 KOO31608.1 - 0.00038 20.2 12.4 0.071 13.0 0.7 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO31608.1 - 0.001 19.3 4.0 15 6.3 0.1 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat AAA_22 PF13401.6 KOO31608.1 - 0.0021 18.4 0.2 0.015 15.6 0.0 2.5 3 0 0 3 3 2 1 AAA domain PPR PF01535.20 KOO31608.1 - 0.01 16.0 0.3 0.38 11.1 0.0 3.5 3 0 0 3 3 3 0 PPR repeat TPR_16 PF13432.6 KOO31608.1 - 0.014 16.0 3.3 0.014 16.0 3.3 6.0 6 1 0 6 6 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO31608.1 - 0.036 14.7 1.7 33 5.5 0.0 5.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 KOO31608.1 - 0.056 13.5 0.4 1.3 9.1 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat IstB_IS21 PF01695.17 KOO31608.1 - 0.066 12.9 0.1 0.37 10.5 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 KOO31608.1 - 0.15 11.8 3.2 0.33 10.7 0.2 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KOO31608.1 - 0.2 11.2 2.0 0.4 10.2 0.1 2.5 3 1 0 3 3 3 0 AAA domain TPR_2 PF07719.17 KOO31608.1 - 0.34 11.1 18.3 0.63 10.3 0.8 5.4 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO31608.1 - 0.69 10.9 14.7 1.3 10.0 0.2 6.5 7 0 0 7 7 6 0 Tetratricopeptide repeat Pkinase PF00069.25 KOO31609.1 - 7.5e-33 114.0 0.0 1e-32 113.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31609.1 - 3.1e-26 92.2 0.0 5.7e-26 91.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO31609.1 - 7.8e-06 24.9 0.0 1.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO31609.1 - 0.00029 20.2 0.0 0.00038 19.9 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO31609.1 - 0.026 14.4 0.0 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.32 KOO31610.1 - 5.6e-09 36.5 0.1 0.037 14.9 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO31610.1 - 0.0091 16.3 0.0 0.73 10.2 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF3515 PF12028.8 KOO31610.1 - 0.094 12.4 0.2 0.15 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3515) 3HCDH_N PF02737.18 KOO31611.1 - 2.4e-59 200.3 0.4 3.2e-59 199.8 0.4 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 KOO31611.1 - 7.3e-33 113.1 0.1 4.1e-32 110.7 0.0 2.1 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KOO31611.1 - 5.7e-06 26.6 4.1 5.9e-05 23.3 4.1 2.1 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 KOO31611.1 - 0.0016 18.9 3.5 0.014 15.9 3.5 2.2 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 KOO31611.1 - 0.007 15.7 1.3 0.014 14.7 1.3 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Spidroin_MaSp PF11260.8 KOO31611.1 - 0.03 14.6 0.0 0.066 13.5 0.0 1.5 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 LpxI_N PF17930.1 KOO31611.1 - 0.1 12.5 0.4 0.4 10.6 0.2 2.0 2 1 1 3 3 3 0 LpxI N-terminal domain UDPG_MGDP_dh_N PF03721.14 KOO31611.1 - 0.3 10.6 2.0 0.59 9.7 2.0 1.7 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain zf-Tim10_DDP PF02953.15 KOO31612.1 - 0.069 12.8 0.3 0.13 11.9 0.3 1.4 1 0 0 1 1 1 0 Tim10/DDP family zinc finger Med3 PF11593.8 KOO31612.1 - 1.7 7.7 7.3 2.8 7.0 7.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Amino_oxidase PF01593.24 KOO31613.1 - 2.3e-63 215.1 2.8 1.2e-62 212.7 2.8 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Hint PF01079.20 KOO31613.1 - 2.2e-23 82.9 0.0 3.5e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Hint module NAD_binding_8 PF13450.6 KOO31613.1 - 4.6e-08 33.2 0.7 1.4e-07 31.6 0.7 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOO31613.1 - 1.5e-07 31.5 1.1 0.0006 19.8 0.1 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.17 KOO31613.1 - 0.0014 17.9 0.2 0.0031 16.8 0.2 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 KOO31613.1 - 0.0082 15.4 0.2 0.11 11.7 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO31613.1 - 0.018 14.3 1.5 0.63 9.2 0.4 2.6 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO31613.1 - 0.02 14.5 7.4 0.086 12.4 7.4 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 KOO31613.1 - 0.062 12.0 0.4 2.5 6.7 0.2 2.2 2 0 0 2 2 2 0 HI0933-like protein Vint PF14623.6 KOO31613.1 - 0.083 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Hint-domain SBBP PF06739.11 KOO31616.1 - 3.8e-15 55.6 46.5 0.00095 19.1 0.5 7.4 7 0 0 7 7 7 6 Beta-propeller repeat Bombesin PF02044.17 KOO31616.1 - 0.0019 18.1 1.4 13 6.1 0.1 5.0 3 0 0 3 3 3 2 Bombesin-like peptide Keratin_2_head PF16208.5 KOO31616.1 - 0.1 12.7 82.8 5.7 7.1 8.0 5.8 1 1 5 6 6 6 0 Keratin type II head Lactamase_B PF00753.27 KOO31616.1 - 4.6 7.2 14.7 0.29 11.1 0.4 4.0 2 1 0 4 4 4 0 Metallo-beta-lactamase superfamily Trypsin_2 PF13365.6 KOO31617.1 - 0.0012 19.8 1.1 0.0032 18.4 1.1 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain Vert_IL3-reg_TF PF06529.11 KOO31619.1 - 0.031 13.4 0.8 0.048 12.8 0.1 1.6 2 0 0 2 2 2 0 Vertebrate interleukin-3 regulated transcription factor Methyltransf_16 PF10294.9 KOO31620.1 - 2.6e-15 56.6 0.0 4e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 KOO31620.1 - 1.4e-05 25.7 0.0 3.4e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO31620.1 - 0.00027 20.5 0.0 0.00044 19.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.16 KOO31620.1 - 0.00059 19.6 0.0 0.00087 19.1 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.12 KOO31620.1 - 0.00065 20.3 0.0 0.0013 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO31620.1 - 0.0036 17.1 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOO31620.1 - 0.0038 17.2 0.0 0.0069 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO31620.1 - 0.0046 16.8 0.0 0.0079 16.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO31620.1 - 0.018 15.8 0.0 0.03 15.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 KOO31620.1 - 0.021 14.2 0.0 0.051 13.0 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 KOO31620.1 - 0.04 13.7 0.0 0.064 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 KOO31620.1 - 0.051 13.5 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain tRNA_U5-meth_tr PF05958.11 KOO31620.1 - 0.063 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase DUF938 PF06080.12 KOO31620.1 - 0.08 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) EF-hand_6 PF13405.6 KOO31622.1 - 7.5e-31 103.4 19.1 1.9e-05 24.2 0.1 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.32 KOO31622.1 - 2.3e-29 98.7 23.9 8.7e-05 21.8 2.9 6.4 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO31622.1 - 1.1e-26 93.1 19.8 2.5e-10 40.6 1.4 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO31622.1 - 1.9e-22 77.7 24.6 0.0081 15.6 0.3 6.4 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.6 KOO31622.1 - 1.8e-18 66.1 25.2 1.1e-06 28.4 0.5 6.1 4 2 2 6 6 6 5 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO31622.1 - 8.4e-05 22.9 5.7 0.22 11.8 0.0 4.1 3 1 1 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO31622.1 - 0.0018 18.6 1.3 23 5.4 0.0 4.8 4 2 0 4 4 4 0 EF-hand domain EF-hand_4 PF12763.7 KOO31622.1 - 0.0036 17.2 0.5 0.0036 17.2 0.5 3.7 3 1 2 5 5 5 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO31622.1 - 0.019 14.8 4.9 4.6 7.2 0.3 4.3 3 1 1 4 4 4 0 EF hand EF-hand_14 PF17959.1 KOO31622.1 - 0.27 11.6 1.0 36 4.8 0.1 3.5 2 1 1 3 3 3 0 EF-hand domain Caleosin PF05042.13 KOO31622.1 - 0.3 11.0 1.3 2.4 8.1 0.0 2.9 3 2 2 5 5 5 0 Caleosin related protein P2X_receptor PF00864.19 KOO31625.1 - 2.6e-28 99.2 0.0 2.2e-17 63.2 0.0 2.1 2 0 0 2 2 2 2 ATP P2X receptor DUF1897 PF09005.10 KOO31625.1 - 0.58 9.7 2.9 1.9 8.0 2.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1897) Nodulin_late PF07127.11 KOO31625.1 - 1.1 9.7 2.8 2.2 8.7 2.8 1.5 1 0 0 1 1 1 0 Late nodulin protein DNA_pol_viral_C PF00336.18 KOO31627.1 - 0.084 12.3 0.0 0.39 10.1 0.0 2.0 2 0 0 2 2 2 0 DNA polymerase (viral) C-terminal domain Complex1_LYR PF05347.15 KOO31628.1 - 6.9e-09 35.6 0.0 1.8e-08 34.3 0.0 1.7 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOO31628.1 - 0.0025 18.5 0.1 0.0056 17.4 0.1 1.8 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 KOO31628.1 - 0.0084 16.7 0.0 0.026 15.1 0.0 1.8 1 0 0 1 1 1 1 Complex1_LYR-like SHE3 PF17078.5 KOO31628.1 - 0.031 14.0 3.8 0.046 13.4 3.5 1.3 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 YtxH PF12732.7 KOO31628.1 - 2.8 8.5 9.4 3.2 8.3 6.7 2.6 2 1 0 2 2 2 0 YtxH-like protein Spc24 PF08286.11 KOO31630.1 - 0.0032 17.7 2.6 0.0032 17.7 2.6 3.0 1 1 2 3 3 3 1 Spc24 subunit of Ndc80 TPR_MLP1_2 PF07926.12 KOO31630.1 - 0.0054 16.8 20.6 0.017 15.2 12.8 2.3 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein Tropomyosin_1 PF12718.7 KOO31630.1 - 0.019 15.1 14.2 0.019 15.1 14.2 2.1 1 1 0 2 2 2 0 Tropomyosin like SlyX PF04102.12 KOO31630.1 - 0.036 14.7 10.7 0.75 10.5 1.6 3.2 2 1 1 3 3 3 0 SlyX Jnk-SapK_ap_N PF09744.9 KOO31630.1 - 0.048 13.9 14.7 0.022 15.0 8.7 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 CENP-F_leu_zip PF10473.9 KOO31630.1 - 0.05 13.6 15.8 0.28 11.2 10.4 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APC_N_CC PF16689.5 KOO31630.1 - 0.064 13.3 14.1 1.4 9.1 0.7 3.5 4 0 0 4 4 3 0 Coiled-coil N-terminus of APC, dimerisation domain B3_4 PF03483.17 KOO31630.1 - 0.096 12.4 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 B3/4 domain DUF4618 PF15397.6 KOO31630.1 - 0.12 11.7 11.7 0.079 12.4 7.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF4191 PF13829.6 KOO31630.1 - 0.13 11.6 1.3 0.31 10.4 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) NPV_P10 PF05531.12 KOO31630.1 - 0.14 12.6 1.0 3.5 8.2 0.0 2.5 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein PhoU PF01895.19 KOO31630.1 - 0.36 11.3 4.8 2.4 8.7 0.5 2.8 2 1 1 3 3 3 0 PhoU domain XhlA PF10779.9 KOO31630.1 - 0.55 10.5 11.2 0.72 10.1 0.6 2.9 2 1 1 3 3 3 0 Haemolysin XhlA KfrA_N PF11740.8 KOO31630.1 - 0.69 10.6 21.1 0.2 12.4 5.7 2.9 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term Fib_alpha PF08702.10 KOO31630.1 - 0.88 9.7 3.4 0.76 10.0 0.9 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family HAUS-augmin3 PF14932.6 KOO31630.1 - 0.89 9.1 13.5 5.7 6.4 13.4 2.0 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 FlaC_arch PF05377.11 KOO31630.1 - 1 9.8 6.1 2.5 8.6 0.3 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) MRP-L28 PF09812.9 KOO31630.1 - 1.4 9.0 9.3 1.8 8.7 8.0 1.9 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L28 Spc7 PF08317.11 KOO31630.1 - 1.5 7.7 17.8 1.4 7.7 7.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4200 PF13863.6 KOO31630.1 - 1.5 9.2 18.8 1.7 9.0 11.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) ATG16 PF08614.11 KOO31630.1 - 1.5 9.0 24.4 3.1 8.0 1.6 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Rop-like PF05082.13 KOO31630.1 - 1.5 8.7 13.2 1.8 8.4 0.6 3.9 4 1 0 4 4 4 0 Rop-like DUF4201 PF13870.6 KOO31630.1 - 1.8 8.2 13.5 2.4 7.9 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Prominin PF05478.11 KOO31630.1 - 2 6.3 4.6 3.2 5.6 4.6 1.3 1 0 0 1 1 1 0 Prominin Cnn_1N PF07989.11 KOO31630.1 - 2.3 8.4 13.5 10 6.4 5.2 3.3 1 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Lectin_N PF03954.14 KOO31630.1 - 2.6 7.8 6.7 32 4.3 0.7 3.1 2 1 0 3 3 3 0 Hepatic lectin, N-terminal domain AAA_13 PF13166.6 KOO31630.1 - 2.8 6.5 12.9 0.15 10.7 2.8 2.3 1 1 1 2 2 2 0 AAA domain Ax_dynein_light PF10211.9 KOO31630.1 - 3.1 7.7 17.6 1.2 9.1 2.6 3.0 2 1 1 3 3 3 0 Axonemal dynein light chain CLZ PF16526.5 KOO31630.1 - 3.2 8.2 16.6 11 6.5 0.3 3.3 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PEARLI-4 PF05278.12 KOO31630.1 - 4.6 6.7 11.8 19 4.7 7.0 2.2 2 1 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF4472 PF14739.6 KOO31630.1 - 5.1 7.9 16.2 3.4 8.4 1.2 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) ADIP PF11559.8 KOO31630.1 - 6.7 6.8 19.8 14 5.7 1.2 3.0 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.20 KOO31630.1 - 9.5 6.2 16.2 11 6.0 2.2 3.2 3 0 0 3 3 3 0 Prefoldin subunit Mg_trans_NIPA PF05653.14 KOO31631.1 - 2.1e-05 23.8 11.9 0.0003 20.0 8.0 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA CENP-F_leu_zip PF10473.9 KOO31631.1 - 0.002 18.2 10.8 0.002 18.2 10.8 5.1 3 3 1 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EamA PF00892.20 KOO31631.1 - 3.6 7.8 16.8 0.46 10.6 8.8 2.4 1 1 1 2 2 2 0 EamA-like transporter family HlyD_2 PF12700.7 KOO31631.1 - 6.7 5.3 5.4 1.8 7.2 1.8 1.7 1 1 1 2 2 2 0 HlyD family secretion protein EF-hand_1 PF00036.32 KOO31632.1 - 1.5e-41 136.9 9.3 5e-06 25.7 0.0 7.6 8 0 0 8 8 8 7 EF hand EF-hand_6 PF13405.6 KOO31632.1 - 1.1e-40 134.1 8.2 2.8e-06 26.8 0.0 8.1 8 0 0 8 8 8 7 EF-hand domain EF-hand_7 PF13499.6 KOO31632.1 - 7e-35 119.3 8.1 6.1e-11 42.6 0.1 5.7 3 2 1 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO31632.1 - 8.6e-31 104.1 12.3 1.5e-05 24.3 0.0 7.7 7 0 0 7 7 7 7 EF hand EF-hand_8 PF13833.6 KOO31632.1 - 8.4e-27 92.8 9.9 1.9e-07 30.8 0.1 7.0 5 2 2 7 7 7 6 EF-hand domain pair EF-hand_11 PF08976.11 KOO31632.1 - 2.5e-05 25.1 0.0 1.5 9.7 0.0 3.6 3 1 0 3 3 3 2 EF-hand domain EF-hand_9 PF14658.6 KOO31632.1 - 5.3e-05 23.5 0.2 6.1 7.2 0.0 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_4 PF12763.7 KOO31632.1 - 0.0016 18.4 2.6 7.2 6.6 0.0 4.1 4 1 0 4 4 4 2 Cytoskeletal-regulatory complex EF hand AA_permease_2 PF13520.6 KOO31634.1 - 3.9e-38 131.4 13.5 5.4e-38 130.9 13.3 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOO31634.1 - 4.1e-18 65.2 20.5 1.1e-17 63.9 20.5 1.5 1 1 0 1 1 1 1 Amino acid permease LEAP-2 PF07359.11 KOO31634.1 - 0.02 14.7 0.0 0.078 12.8 0.0 2.0 1 0 0 1 1 1 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) DUF4381 PF14316.6 KOO31634.1 - 0.26 11.5 5.6 0.2 11.9 2.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4381) CX9C PF16860.5 KOO31635.1 - 8.8e-05 22.4 1.1 0.017 15.2 0.4 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 KOO31635.1 - 0.00032 20.8 4.7 0.2 11.8 0.1 2.6 2 1 0 2 2 2 2 CHCH domain NDUF_B7 PF05676.13 KOO31635.1 - 0.016 15.0 0.8 0.068 12.9 0.2 2.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX6B PF02297.17 KOO31635.1 - 0.1 12.8 5.6 0.96 9.7 5.6 2.1 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb TSP_1 PF00090.19 KOO31635.1 - 0.54 10.5 3.2 35 4.7 1.5 2.7 2 1 1 3 3 3 0 Thrombospondin type 1 domain EF-hand_7 PF13499.6 KOO31636.1 - 9.4e-11 42.0 0.0 7.4e-10 39.1 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO31636.1 - 2.7e-09 36.7 0.0 0.0025 17.6 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO31636.1 - 3.5e-09 35.6 0.2 0.0021 17.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31636.1 - 4.2e-07 29.4 0.1 0.028 14.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO31636.1 - 2.9e-06 26.5 0.1 0.081 12.4 0.0 2.4 2 0 0 2 2 2 2 EF hand FHA PF00498.26 KOO31636.1 - 6.8e-06 26.3 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain WW PF00397.26 KOO31636.1 - 0.0013 18.8 0.1 0.0024 17.9 0.1 1.5 1 0 0 1 1 1 1 WW domain EF-hand_4 PF12763.7 KOO31636.1 - 0.0019 18.1 0.0 0.19 11.7 0.0 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Cucumo_2B PF03263.13 KOO31636.1 - 0.092 13.2 0.1 0.29 11.6 0.1 1.8 1 0 0 1 1 1 0 Cucumovirus protein 2B PI3_PI4_kinase PF00454.27 KOO31638.1 - 6.7e-10 39.2 0.0 9.4e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TPR_8 PF13181.6 KOO31639.1 - 0.015 15.5 0.0 0.054 13.7 0.0 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO31639.1 - 0.029 14.5 0.2 0.029 14.5 0.2 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO31639.1 - 0.06 13.2 0.0 0.06 13.2 0.0 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO31639.1 - 0.16 12.7 0.0 0.16 12.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO31639.1 - 0.27 12.2 6.5 2.1 9.4 6.5 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat cNMP_binding PF00027.29 KOO31640.1 - 8.6e-17 61.0 0.1 1.6e-16 60.1 0.1 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KOO31640.1 - 2.7e-07 30.4 0.2 2.7e-07 30.4 0.2 1.8 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.31 KOO31640.1 - 1.4e-05 24.4 0.0 2.8e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Ion transport protein zf-rbx1 PF12678.7 KOO31641.1 - 5.1e-21 74.7 4.1 7.3e-21 74.2 4.1 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOO31641.1 - 3.9e-14 52.5 7.3 5e-14 52.1 7.3 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 KOO31641.1 - 1.8e-09 37.8 9.5 2.3e-08 34.2 9.5 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO31641.1 - 9.4e-09 35.0 5.7 4.4e-07 29.6 2.6 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO31641.1 - 1.7e-07 31.0 1.1 4.9e-07 29.5 1.1 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO31641.1 - 7.4e-07 29.1 0.3 1.7e-06 27.9 0.1 1.8 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KOO31641.1 - 4.5e-05 23.2 5.2 0.00011 22.0 1.0 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOO31641.1 - 5.2e-05 23.1 4.8 0.00016 21.6 4.9 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOO31641.1 - 0.00026 20.8 5.3 0.00072 19.4 0.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KOO31641.1 - 0.0024 17.4 3.8 0.0024 17.4 3.8 2.2 2 1 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 KOO31641.1 - 0.0026 17.5 1.3 0.0026 17.5 1.3 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-Nse PF11789.8 KOO31641.1 - 0.013 15.3 0.2 0.025 14.4 0.2 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF2318 PF10080.9 KOO31641.1 - 0.039 14.1 1.2 2.2 8.5 0.1 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2318) zinc_ribbon_16 PF17034.5 KOO31641.1 - 0.049 13.9 5.0 0.063 13.5 4.4 1.7 1 1 0 1 1 1 0 Zinc-ribbon like family zf-C3HC4_4 PF15227.6 KOO31641.1 - 0.061 13.5 4.3 0.061 13.5 4.3 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 KOO31641.1 - 0.25 10.7 1.0 0.41 10.0 0.1 1.7 2 0 0 2 2 2 0 Rtf2 RING-finger zf-C3H2C3 PF17122.5 KOO31641.1 - 0.34 11.0 7.1 0.12 12.4 3.1 2.2 2 1 0 2 2 2 0 Zinc-finger RINGv PF12906.7 KOO31641.1 - 2.1 8.6 11.1 0.25 11.5 4.8 2.2 2 0 0 2 2 2 0 RING-variant domain Mito_carr PF00153.27 KOO31642.1 - 5.9e-27 93.4 2.4 4e-14 52.3 0.1 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein ADK PF00406.22 KOO31644.1 - 5.2e-51 172.7 0.0 7.2e-51 172.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO31644.1 - 6.3e-24 84.9 0.0 1.3e-23 83.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 KOO31644.1 - 1.2e-13 50.8 0.0 2.2e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid NDK PF00334.19 KOO31644.1 - 8.7e-06 25.8 0.0 0.012 15.7 0.0 2.4 2 0 0 2 2 2 2 Nucleoside diphosphate kinase Hydin_ADK PF17213.3 KOO31644.1 - 0.0013 19.1 0.4 0.0061 16.9 0.1 2.0 1 1 1 2 2 2 1 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 KOO31644.1 - 0.014 16.0 0.0 0.028 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO31644.1 - 0.021 15.0 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain TetR_C_31 PF17940.1 KOO31645.1 - 0.029 14.6 0.8 0.052 13.7 0.2 1.7 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TPR_14 PF13428.6 KOO31645.1 - 0.15 12.9 3.1 0.55 11.2 0.1 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat SET PF00856.28 KOO31647.1 - 5e-06 27.0 0.0 4e-05 24.1 0.0 2.0 1 1 0 1 1 1 1 SET domain Metallophos PF00149.28 KOO31648.1 - 2.8e-08 34.5 0.0 4.5e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase UAA PF08449.11 KOO31649.1 - 1.3e-08 34.5 11.0 2.4e-08 33.6 10.8 1.7 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.16 KOO31649.1 - 1.1e-06 28.3 11.3 5e-06 26.1 11.3 1.9 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO31649.1 - 0.12 12.6 24.2 0.14 12.4 11.7 3.2 2 2 1 3 3 3 0 EamA-like transporter family Hint PF01079.20 KOO31650.1 - 5e-22 78.5 0.1 8.5e-22 77.7 0.1 1.3 1 0 0 1 1 1 1 Hint module SecY PF00344.20 KOO31650.1 - 1e-17 64.4 0.0 1.8e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 SecY translocase Vint PF14623.6 KOO31650.1 - 0.028 14.2 0.1 0.045 13.6 0.1 1.3 1 0 0 1 1 1 0 Hint-domain FANCAA PF15146.6 KOO31650.1 - 0.066 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Fanconi anemia-associated DUF3487 PF11990.8 KOO31650.1 - 0.089 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) PAXNEB PF05625.11 KOO31652.1 - 0.019 14.1 6.9 0.032 13.4 6.9 1.2 1 0 0 1 1 1 0 PAXNEB protein Syntaxin-6_N PF09177.11 KOO31652.1 - 0.17 12.4 4.7 0.7 10.5 1.6 3.3 3 0 0 3 3 3 0 Syntaxin 6, N-terminal Bul1_C PF04426.12 KOO31652.1 - 0.18 11.2 0.0 0.18 11.2 0.0 3.1 3 0 0 3 3 3 0 Bul1 C terminus MPS2 PF17060.5 KOO31652.1 - 0.82 8.9 8.3 1.3 8.2 8.3 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 LMBR1 PF04791.16 KOO31652.1 - 7.5 5.3 5.1 12 4.7 5.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein ABC1 PF03109.16 KOO31653.1 - 1.4e-23 83.3 0.0 2.3e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 KOO31654.1 - 7e-32 110.8 0.0 1e-31 110.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31654.1 - 5.9e-30 104.4 0.0 8.4e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Methyltransf_11 PF08241.12 KOO31654.1 - 6e-12 46.1 0.0 1.4e-11 44.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO31654.1 - 2.1e-11 44.4 0.0 5.1e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO31654.1 - 0.00014 21.8 0.1 0.00033 20.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO31654.1 - 0.00016 21.5 0.0 0.00044 20.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Kinase-like PF14531.6 KOO31654.1 - 0.00093 18.6 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO31654.1 - 0.0028 17.6 0.4 0.0028 17.6 0.4 2.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO31654.1 - 0.0037 16.1 0.0 0.0076 15.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Methyltransf_12 PF08242.12 KOO31654.1 - 0.005 17.6 0.0 0.012 16.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain TIR_2 PF13676.6 KOO31654.1 - 0.02 15.5 0.0 0.044 14.4 0.0 1.5 1 0 0 1 1 1 0 TIR domain MetW PF07021.12 KOO31654.1 - 0.067 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Kdo PF06293.14 KOO31654.1 - 0.12 11.7 0.2 0.2 11.0 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TLD PF07534.16 KOO31655.1 - 2.2e-21 76.5 0.0 3.3e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 TLD LpxI_N PF17930.1 KOO31655.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 LpxI N-terminal domain UQ_con PF00179.26 KOO31656.1 - 2.6e-18 66.0 0.0 3.8e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOO31656.1 - 0.0024 18.1 0.0 0.0037 17.5 0.0 1.3 1 0 0 1 1 1 1 RWD domain XhlA PF10779.9 KOO31656.1 - 0.11 12.7 0.6 0.21 11.8 0.6 1.3 1 0 0 1 1 1 0 Haemolysin XhlA Dimer_Tnp_hAT PF05699.14 KOO31658.1 - 1.7e-06 27.7 0.0 4.1e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region AKAP95 PF04988.12 KOO31658.1 - 0.0028 17.9 1.0 0.0069 16.6 0.4 1.9 2 0 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) GAGBD PF16828.5 KOO31658.1 - 0.0079 16.3 0.3 0.015 15.4 0.3 1.3 1 0 0 1 1 1 1 GAG-binding domain on surface antigen Actin_micro PF17003.5 KOO31658.1 - 0.033 13.4 1.7 0.21 10.7 0.8 2.1 1 1 0 2 2 2 0 Putative actin-like family PAN_4 PF14295.6 KOO31659.1 - 0.044 13.7 2.0 0.14 12.1 2.0 1.9 1 0 0 1 1 1 0 PAN domain AAA_5 PF07728.14 KOO31660.1 - 9.2e-75 249.2 0.0 4.5e-26 91.5 0.0 3.4 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO31660.1 - 3.8e-07 30.5 0.3 0.0014 18.9 0.0 3.6 2 2 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KOO31660.1 - 5.2e-05 23.7 13.4 0.0045 17.4 0.1 5.5 4 2 1 5 5 5 2 AAA ATPase domain AAA PF00004.29 KOO31660.1 - 0.0002 21.8 0.0 0.017 15.5 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 KOO31660.1 - 0.00078 19.3 0.0 0.18 11.7 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KOO31660.1 - 0.0025 18.0 0.0 0.11 12.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 KOO31660.1 - 0.0041 16.5 4.8 1.2 8.4 0.1 3.6 3 1 1 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 KOO31660.1 - 0.0072 15.9 0.0 3 7.3 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 KOO31660.1 - 0.0097 15.8 0.4 1 9.2 0.0 3.3 3 0 0 3 3 3 1 NACHT domain AAA_30 PF13604.6 KOO31660.1 - 0.024 14.4 0.1 2.3 7.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOO31660.1 - 0.038 13.7 0.0 4.7 7.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 KOO31660.1 - 0.081 12.6 0.0 0.56 9.9 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein TsaE PF02367.17 KOO31660.1 - 0.096 12.7 0.0 1 9.4 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 KOO31660.1 - 0.14 12.7 0.0 0.59 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 KOO31660.1 - 0.18 11.5 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_24 PF13479.6 KOO31660.1 - 0.18 11.5 0.0 1.7 8.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 KOO31660.1 - 0.21 11.8 0.0 18 5.6 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RRM_1 PF00076.22 KOO31661.1 - 1.3e-61 204.3 1.7 4.1e-20 71.4 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KOO31661.1 - 1.8e-24 85.7 0.1 2e-23 82.4 0.1 2.6 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 KOO31661.1 - 7.1e-11 41.8 0.2 0.0082 15.7 0.0 3.3 1 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arm PF00514.23 KOO31661.1 - 1.9e-09 37.3 1.5 6.2e-05 22.9 0.8 2.7 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat RRM_occluded PF16842.5 KOO31661.1 - 5.2e-06 26.2 0.0 0.16 11.9 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif HEAT PF02985.22 KOO31661.1 - 0.0029 17.7 0.2 0.043 14.1 0.0 2.8 2 0 0 2 2 2 1 HEAT repeat RRM_3 PF08777.11 KOO31661.1 - 0.0038 17.3 1.6 2.4 8.2 0.0 3.6 4 0 0 4 4 4 1 RNA binding motif HEAT_EZ PF13513.6 KOO31661.1 - 0.057 13.9 0.3 0.057 13.9 0.3 3.5 2 1 1 3 3 3 0 HEAT-like repeat HEAT_2 PF13646.6 KOO31661.1 - 0.094 13.1 7.8 0.11 12.9 4.0 2.8 1 1 1 2 2 2 0 HEAT repeats EamA PF00892.20 KOO31664.1 - 1.5e-05 25.2 20.5 2.1e-05 24.7 0.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family Hid1 PF12722.7 KOO31664.1 - 0.14 10.3 0.0 0.19 9.8 0.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ETC_C1_NDUFA5 PF04716.14 KOO31665.1 - 4.2e-19 68.1 0.0 6.9e-19 67.4 0.0 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region PCI PF01399.27 KOO31666.1 - 6.7e-13 49.1 0.0 1.3e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 PCI domain eIF3m_C_helix PF18005.1 KOO31666.1 - 9.4e-05 22.0 1.0 9.4e-05 22.0 1.0 2.3 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix Sigma70_r4_2 PF08281.12 KOO31666.1 - 0.017 14.8 0.3 0.25 11.1 0.0 2.6 2 0 0 2 2 2 0 Sigma-70, region 4 P21-Arc PF04062.14 KOO31667.1 - 2.7e-64 216.4 0.0 3.7e-64 216.0 0.0 1.2 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Methyltransf_25 PF13649.6 KOO31668.1 - 1e-07 32.5 0.7 2.2e-07 31.5 0.1 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO31668.1 - 1.1e-06 29.2 0.1 2.1e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO31668.1 - 1.1e-05 26.1 0.0 2.7e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO31668.1 - 0.00026 20.8 0.0 0.00045 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO31668.1 - 0.012 15.2 0.1 0.024 14.2 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 KOO31668.1 - 0.037 13.3 0.0 0.05 12.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KOO31668.1 - 0.096 12.5 0.0 0.15 11.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 KOO31668.1 - 0.12 12.1 0.1 0.25 11.0 0.1 1.6 1 1 0 1 1 1 0 Lysine methyltransferase Na_H_Exchanger PF00999.21 KOO31669.1 - 2.5e-48 164.8 27.8 2.5e-48 164.8 27.8 2.0 1 1 1 2 2 2 2 Sodium/hydrogen exchanger family Peptidase_M24 PF00557.24 KOO31671.1 - 1.6e-52 178.2 0.0 2.4e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 KOO31671.1 - 7.4e-16 58.0 0.0 1.4e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain AhpC-TSA PF00578.21 KOO31672.1 - 0.022 14.7 0.0 0.052 13.5 0.0 1.7 1 0 0 1 1 1 0 AhpC/TSA family V-ATPase_G PF03179.15 KOO31675.1 - 4.1e-27 94.8 9.2 4.8e-27 94.6 9.2 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Adenine_deam_C PF13382.6 KOO31675.1 - 0.04 13.3 0.2 0.072 12.4 0.1 1.5 1 1 1 2 2 2 0 Adenine deaminase C-terminal domain DUF4407 PF14362.6 KOO31675.1 - 0.058 12.7 3.8 0.067 12.5 3.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3072 PF11272.8 KOO31675.1 - 2 8.4 5.2 3.2 7.7 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3072) Pkinase PF00069.25 KOO31677.1 - 0.016 14.6 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.25 KOO31678.1 - 1.2e-54 185.5 0.0 1.6e-54 185.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31678.1 - 2.4e-34 118.8 0.0 3.1e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO31678.1 - 0.00063 18.6 0.0 0.00085 18.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO31678.1 - 0.012 15.6 0.2 0.099 12.5 0.0 2.3 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO31678.1 - 0.16 11.3 0.0 9.5 5.4 0.0 3.1 3 1 0 3 3 3 0 Kinase-like Seadorna_VP7 PF07387.11 KOO31678.1 - 0.26 10.3 0.0 0.4 9.7 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 EF-hand_1 PF00036.32 KOO31679.1 - 1.7e-25 86.6 7.1 2.1e-05 23.8 0.1 5.6 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.6 KOO31679.1 - 1.8e-21 76.4 7.5 5.4e-10 39.6 0.1 4.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO31679.1 - 2e-18 64.7 0.2 0.0031 17.3 0.0 6.0 6 0 0 6 6 6 5 EF-hand domain EF-hand_5 PF13202.6 KOO31679.1 - 5.4e-17 60.4 11.0 0.0013 18.1 0.1 5.0 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO31679.1 - 4e-16 58.6 11.4 1.8e-06 27.7 0.7 4.0 3 1 1 4 4 4 3 EF-hand domain pair PDZ PF00595.24 KOO31679.1 - 1.2e-13 51.2 0.1 6.6e-06 26.4 0.0 3.5 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 KOO31679.1 - 6.5e-12 45.1 0.1 6.6e-08 32.3 0.0 2.8 2 0 0 2 2 2 2 PDZ domain EF-hand_4 PF12763.7 KOO31679.1 - 3.1e-09 36.7 1.5 0.066 13.2 0.1 3.6 3 1 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO31679.1 - 7.5e-08 32.7 0.0 0.19 12.1 0.0 3.4 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region PDZ_2 PF13180.6 KOO31679.1 - 2.8e-07 30.8 0.0 0.0078 16.5 0.0 2.8 2 0 0 2 2 2 2 PDZ domain Dockerin_1 PF00404.18 KOO31679.1 - 3.1e-05 24.1 5.8 0.11 12.8 0.1 3.7 3 1 0 3 3 3 2 Dockerin type I domain EF-hand_9 PF14658.6 KOO31679.1 - 0.0009 19.5 2.8 1.5 9.2 0.0 3.7 4 0 0 4 4 3 1 EF-hand domain RuvB_N PF05496.12 KOO31679.1 - 0.027 14.2 0.0 5.7 6.7 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Tricorn_PDZ PF14685.6 KOO31679.1 - 0.028 14.4 0.1 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 Tricorn protease PDZ domain CEP19 PF14933.6 KOO31679.1 - 0.04 14.2 2.2 16 5.8 0.1 3.3 3 0 0 3 3 3 0 CEP19-like protein DUF2939 PF11159.8 KOO31679.1 - 1.1 9.7 5.8 5.7 7.4 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2939) RibD_C PF01872.17 KOO31681.1 - 3.4e-35 121.7 0.0 4.6e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 RibD C-terminal domain EF-hand_1 PF00036.32 KOO31682.1 - 4.3e-30 101.0 22.0 4.5e-09 35.2 0.0 4.5 5 0 0 5 5 4 4 EF hand EF-hand_7 PF13499.6 KOO31682.1 - 4.6e-30 103.9 8.7 6.8e-17 61.7 0.5 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO31682.1 - 1.3e-25 89.0 10.7 5.6e-12 45.3 0.3 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO31682.1 - 1.5e-24 83.8 14.5 2.6e-09 36.3 0.0 5.2 4 2 2 7 7 7 4 EF-hand domain EF-hand_5 PF13202.6 KOO31682.1 - 1.1e-19 68.9 9.6 2.1e-06 27.0 0.2 5.0 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.6 KOO31682.1 - 6.5e-14 52.0 0.2 7.9e-08 32.5 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO31682.1 - 3.7e-06 26.8 4.7 0.2 11.6 0.9 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SurA_N_3 PF13624.6 KOO31682.1 - 0.00019 21.3 0.6 0.48 10.2 0.1 2.1 1 1 1 2 2 2 2 SurA N-terminal domain Caleosin PF05042.13 KOO31682.1 - 0.00033 20.6 0.9 4.5 7.2 0.0 3.7 1 1 3 4 4 4 1 Caleosin related protein SurA_N_2 PF13623.6 KOO31682.1 - 0.00087 19.2 0.7 0.88 9.4 0.0 2.3 1 1 1 2 2 2 2 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KOO31682.1 - 0.0025 18.1 0.5 0.74 10.1 0.2 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOO31682.1 - 0.0034 17.7 0.8 1.5 9.2 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain SUB1_ProdP9 PF18213.1 KOO31682.1 - 0.012 15.5 1.6 0.029 14.2 0.5 2.1 1 1 2 3 3 3 0 SUB1 protease Prodomain ProdP9 DUF3008 PF11450.8 KOO31682.1 - 0.024 14.8 0.2 0.024 14.8 0.2 3.2 4 0 0 4 4 3 0 Protein of unknwon function (DUF3008) TerB PF05099.13 KOO31682.1 - 0.053 13.5 1.6 6.1 6.8 0.1 2.5 1 1 1 2 2 2 0 Tellurite resistance protein TerB LETM1 PF07766.13 KOO31682.1 - 0.057 12.8 0.8 0.17 11.2 0.7 1.8 1 1 0 1 1 1 0 LETM1-like protein Peptidase_M24 PF00557.24 KOO31682.1 - 0.08 12.6 0.2 1.8 8.2 0.0 2.5 2 1 1 3 3 3 0 Metallopeptidase family M24 DUF3911 PF13050.6 KOO31682.1 - 0.13 12.4 1.5 0.43 10.7 0.7 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3911) Acetyltransf_11 PF13720.6 KOO31682.1 - 0.16 12.5 0.4 1.2 9.6 0.1 2.3 1 1 1 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 PMBR PF09373.10 KOO31682.1 - 0.16 12.2 0.2 23 5.4 0.0 4.2 6 0 0 6 6 6 0 Pseudomurein-binding repeat DUF1456 PF07308.13 KOO31682.1 - 0.17 12.2 3.5 6.2 7.2 0.1 3.3 2 1 1 3 3 2 0 Protein of unknown function (DUF1456) YolD PF08863.10 KOO31682.1 - 0.22 11.6 2.3 10 6.2 0.1 2.8 3 1 0 3 3 3 0 YolD-like protein SapB_1 PF05184.15 KOO31682.1 - 1.2 9.3 6.8 3.2 7.8 0.2 2.7 3 0 0 3 3 2 0 Saposin-like type B, region 1 Bac_DNA_binding PF00216.21 KOO31683.1 - 2.2e-28 98.3 0.3 2.5e-28 98.1 0.3 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 KOO31683.1 - 5e-08 33.1 0.0 6.2e-08 32.8 0.0 1.0 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif LacI PF00356.21 KOO31683.1 - 0.049 13.4 1.7 0.089 12.6 1.7 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family S1-like PF14444.6 KOO31683.1 - 0.095 12.6 0.1 7.6 6.5 0.0 2.3 2 0 0 2 2 2 0 S1-like HU-CCDC81_bac_2 PF18175.1 KOO31683.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 TRAM_LAG1_CLN8 PF03798.16 KOO31684.1 - 2.6e-07 30.6 2.1 3.6e-07 30.1 2.1 1.3 1 0 0 1 1 1 1 TLC domain DEAD PF00270.29 KOO31685.1 - 3.6e-10 39.9 0.0 5.7e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO31685.1 - 0.012 15.9 0.0 0.021 15.2 0.0 1.4 1 0 0 1 1 1 0 Helicase conserved C-terminal domain UVR PF02151.19 KOO31685.1 - 0.07 12.9 0.9 0.16 11.7 0.9 1.5 1 0 0 1 1 1 0 UvrB/uvrC motif T4SS-DNA_transf PF02534.14 KOO31685.1 - 0.14 11.0 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Endonuclease_7 PF02945.15 KOO31686.1 - 0.018 15.0 0.1 0.042 13.8 0.1 1.5 1 0 0 1 1 1 0 Recombination endonuclease VII Neuropep_like PF15161.6 KOO31687.1 - 0.02 14.5 1.1 5.6 6.7 0.1 2.6 2 0 0 2 2 2 0 Neuropeptide-like SCP1201-deam PF14428.6 KOO31687.1 - 0.18 11.6 8.4 4.7 7.1 0.3 3.1 1 1 2 3 3 3 0 SCP1.201-like deaminase VCBS PF13517.6 KOO31688.1 - 1.5e-153 499.5 159.1 1e-13 51.6 4.7 15.1 1 1 14 15 15 15 15 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO31688.1 - 2.6e-73 241.7 162.6 1e-05 25.6 1.1 16.5 16 0 0 16 16 16 16 FG-GAP repeat Dockerin_1 PF00404.18 KOO31688.1 - 2.5e-22 78.8 45.0 0.65 10.2 0.1 16.1 16 0 0 16 16 16 9 Dockerin type I domain Arrestin_N PF00339.29 KOO31688.1 - 5.8e-07 29.7 0.0 61 3.6 0.0 10.1 12 1 1 13 13 13 0 Arrestin (or S-antigen), N-terminal domain BBS1 PF14779.6 KOO31688.1 - 9.9e-07 28.5 9.5 39 3.6 0.0 12.1 15 1 1 16 16 16 0 Ciliary BBSome complex subunit 1 TM_PBP2_N PF16296.5 KOO31688.1 - 1.2e-05 25.4 0.0 83 3.4 0.0 8.7 12 0 0 12 12 12 0 N-terminal of TM subunit in PBP-dependent ABC transporters TcdB_toxin_midN PF12256.8 KOO31688.1 - 1.6e-05 24.3 78.6 1.1 8.6 0.2 15.8 3 3 11 16 16 16 6 Insecticide toxin TcdB middle/N-terminal region DUF1629 PF07791.11 KOO31688.1 - 2.4e-05 24.4 0.1 1.9e+02 2.2 0.0 9.0 10 2 1 13 13 13 0 Protein of unknown function (DUF1629) Cucumo_2B PF03263.13 KOO31688.1 - 0.018 15.5 0.4 1.4e+02 3.0 0.0 6.8 10 0 0 10 10 9 0 Cucumovirus protein 2B EF-hand_1 PF00036.32 KOO31688.1 - 0.033 13.7 71.5 16 5.4 0.3 16.0 16 0 0 16 16 16 0 EF hand EF-hand_5 PF13202.6 KOO31688.1 - 0.35 10.5 108.6 5.7 6.6 1.3 16.5 16 0 0 16 16 16 0 EF hand DnaJ PF00226.31 KOO31689.1 - 0.0023 18.0 0.0 0.0047 17.0 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain RPGR1_C PF18111.1 KOO31690.1 - 0.083 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Retinitis pigmentosa G-protein regulator interacting C-terminal DUF547 PF04784.14 KOO31692.1 - 1.9e-27 95.7 0.0 3.8e-27 94.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF547 DUF948 PF06103.11 KOO31693.1 - 4 7.8 11.5 9 6.6 0.2 3.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Bactofilin PF04519.13 KOO31696.1 - 0.061 13.6 1.6 0.24 11.7 0.6 2.2 2 0 0 2 2 2 0 Polymer-forming cytoskeletal zf-TRAF PF02176.18 KOO31697.1 - 0.52 11.0 2.4 33 5.3 0.1 2.8 2 1 1 3 3 3 0 TRAF-type zinc finger EF-hand_1 PF00036.32 KOO31698.1 - 2.4e-14 51.7 0.2 0.00037 19.8 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO31698.1 - 4.6e-14 51.1 0.2 0.00032 20.4 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KOO31698.1 - 6.3e-13 47.6 0.2 3.2e-05 23.2 0.0 3.2 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO31698.1 - 2e-12 47.4 0.1 4.6e-09 36.6 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO31698.1 - 6e-09 35.6 0.3 6.7e-06 25.9 0.1 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO31698.1 - 0.0014 18.5 0.1 0.34 10.9 0.0 2.8 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand IQ PF00612.27 KOO31698.1 - 0.017 14.9 3.1 0.15 12.0 0.4 2.9 3 0 0 3 3 3 0 IQ calmodulin-binding motif SPARC_Ca_bdg PF10591.9 KOO31698.1 - 0.026 14.8 0.5 0.2 12.0 0.3 2.3 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO31698.1 - 0.053 13.9 0.0 0.23 11.8 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain Kri1 PF05178.12 KOO31699.1 - 6.3e-21 74.9 4.8 6.3e-21 74.9 4.8 5.0 5 1 1 6 6 6 1 KRI1-like family Kri1_C PF12936.7 KOO31699.1 - 8.2e-15 54.8 0.0 8.2e-15 54.8 0.0 3.3 5 0 0 5 5 5 1 KRI1-like family C-terminal Vpu PF00558.19 KOO31699.1 - 1.6 8.5 6.5 0.34 10.7 0.7 2.7 2 0 0 2 2 2 0 Vpu protein EF-hand_1 PF00036.32 KOO31700.1 - 1.9e-05 23.9 0.0 0.00037 19.8 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO31700.1 - 0.00069 19.0 0.1 0.012 15.0 0.1 2.7 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO31700.1 - 0.0014 18.4 0.0 0.0044 16.8 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO31700.1 - 0.0024 17.6 0.1 0.023 14.6 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO31700.1 - 0.075 13.5 0.2 0.81 10.2 0.0 2.7 2 1 0 2 2 2 0 EF-hand domain pair DUF4375 PF14300.6 KOO31700.1 - 1.3 9.3 6.1 0.47 10.7 1.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) DUF948 PF06103.11 KOO31700.1 - 9.7 6.5 8.0 73 3.7 3.0 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) 2OG-FeII_Oxy_3 PF13640.6 KOO31701.1 - 2.1e-08 34.9 0.0 4.1e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 KOO31701.1 - 0.003 16.7 0.0 0.0069 15.5 0.0 1.4 1 1 0 1 1 1 1 Poxvirus C4/C10 protein KDZ PF18758.1 KOO31702.1 - 2.3e-10 40.5 2.3 3e-10 40.1 2.3 1.2 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase Chromo PF00385.24 KOO31702.1 - 0.00016 21.5 0.1 0.00026 20.8 0.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SbcD_C PF12320.8 KOO31703.1 - 0.067 13.5 0.0 57 4.1 0.0 4.1 4 0 0 4 4 4 0 Type 5 capsule protein repressor C-terminal domain CBP_BcsF PF11120.8 KOO31703.1 - 0.14 12.3 1.0 36 4.6 0.0 4.1 3 0 0 3 3 3 0 Cellulose biosynthesis protein BcsF Glycogen_syn PF05693.13 KOO31703.1 - 0.18 10.3 0.1 13 4.2 0.0 3.1 2 0 0 2 2 2 0 Glycogen synthase DUF4267 PF14087.6 KOO31703.1 - 3.9 7.6 7.4 2.1e+02 2.0 0.0 5.6 6 0 0 6 6 6 0 Domain of unknown function (DUF4267) MFS_1 PF07690.16 KOO31704.1 - 3.2e-22 78.9 59.9 1.5e-19 70.1 45.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily UreD PF01774.17 KOO31705.1 - 3.4e-29 102.3 0.1 5.7e-29 101.6 0.1 1.4 1 1 0 1 1 1 1 UreD urease accessory protein XPG_I PF00867.18 KOO31706.1 - 3.5e-16 59.3 0.0 6.5e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 KOO31706.1 - 1.9e-15 57.2 0.0 3.4e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 KOO31706.1 - 6.4e-06 25.8 0.0 9e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing JmjC PF02373.22 KOO31707.1 - 1.2e-15 57.9 0.0 3.7e-15 56.4 0.0 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase Chromo PF00385.24 KOO31707.1 - 2e-06 27.6 2.1 5.3e-06 26.3 2.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Arm PF00514.23 KOO31709.1 - 8.8e-74 241.5 55.5 2.2e-06 27.5 0.0 21.6 20 2 2 22 22 22 17 Armadillo/beta-catenin-like repeat ACC_central PF08326.12 KOO31709.1 - 1.1e-24 86.8 0.1 1.1e-24 86.8 0.1 1.9 2 1 0 2 2 2 1 Acetyl-CoA carboxylase, central region Atx10homo_assoc PF09759.9 KOO31709.1 - 1.6e-12 47.3 11.2 0.4 10.7 0.0 8.6 7 1 2 9 9 9 3 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO31709.1 - 1.7e-09 37.5 3.7 0.05 13.0 0.0 6.5 6 2 2 8 8 8 2 Armadillo-like DUF5578 PF17741.1 KOO31709.1 - 5.5e-07 29.3 5.3 0.00039 19.9 0.1 5.7 5 1 1 6 6 6 2 Family of unknown function (DUF5578) Cnd1 PF12717.7 KOO31709.1 - 6.3e-07 29.6 0.0 0.18 11.9 0.0 5.5 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOO31709.1 - 1.3e-05 25.5 44.1 0.0063 16.9 2.1 8.4 5 2 2 8 8 8 4 HEAT repeats Adaptin_N PF01602.20 KOO31709.1 - 0.00013 20.7 0.5 0.87 8.1 0.0 3.8 2 1 1 3 3 3 2 Adaptin N terminal region HEAT_EZ PF13513.6 KOO31709.1 - 0.017 15.6 38.3 1.1 9.8 0.1 10.0 9 0 0 9 9 9 0 HEAT-like repeat TIG PF01833.24 KOO31709.1 - 0.037 14.1 0.1 0.62 10.2 0.1 2.4 2 0 0 2 2 2 0 IPT/TIG domain HEAT PF02985.22 KOO31709.1 - 0.047 14.0 8.6 5.2 7.6 0.3 6.7 5 0 0 5 5 5 0 HEAT repeat MAD PF05557.13 KOO31709.1 - 4.8 5.4 31.6 9.1 4.5 31.6 1.4 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF4666 PF15697.5 KOO31710.1 - 1 10.1 5.3 55 4.5 5.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4666) EF-hand_6 PF13405.6 KOO31711.1 - 4.2e-09 35.6 0.1 2.1e-05 24.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO31711.1 - 1.1e-07 30.8 0.0 9.5e-05 21.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO31711.1 - 1.7e-06 28.4 0.0 0.0027 18.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO31711.1 - 3.1e-05 23.3 0.0 0.0036 16.7 0.0 2.4 2 0 0 2 2 2 2 EF hand DUF4381 PF14316.6 KOO31711.1 - 0.16 12.2 0.0 0.16 12.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) PDZ_6 PF17820.1 KOO31712.1 - 0.017 15.0 0.1 0.03 14.2 0.1 1.5 1 0 0 1 1 1 0 PDZ domain rve PF00665.26 KOO31713.1 - 1.3e-05 25.3 0.0 2e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Aa_trans PF01490.18 KOO31714.1 - 3.1e-20 72.3 23.2 1.8e-19 69.7 9.4 2.2 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein Gly_transf_sug PF04488.15 KOO31715.1 - 1.9e-05 25.2 0.0 3.5e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif tRNA-synt_2b PF00587.25 KOO31716.1 - 2.2e-31 109.2 0.0 3.5e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 KOO31716.1 - 6.2e-13 48.9 4.2 8.8e-13 48.4 4.2 1.2 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain RdRP_4 PF02123.16 KOO31717.1 - 4.5 6.0 11.4 6.6 5.5 11.4 1.3 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase CBP_BcsG PF11658.8 KOO31718.1 - 0.21 10.0 0.0 0.31 9.4 0.0 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG GHMP_kinases_N PF00288.26 KOO31719.1 - 9.3e-12 45.0 5.5 6.2e-11 42.4 5.5 2.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KOO31719.1 - 1.6e-06 28.4 0.3 6.1e-06 26.5 0.3 2.0 1 0 0 1 1 1 1 GHMP kinases C terminal Agenet PF05641.12 KOO31720.1 - 0.048 14.1 0.0 0.11 13.0 0.0 1.6 1 0 0 1 1 1 0 Agenet domain SET PF00856.28 KOO31721.1 - 4.9e-09 36.8 0.0 9.8e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 SET domain DUF4505 PF14956.6 KOO31722.1 - 4.5e-18 65.6 0.0 6.5e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) TTL PF03133.15 KOO31723.1 - 1.4e-61 208.2 0.0 3.7e-61 206.8 0.0 1.7 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO31723.1 - 7.3e-09 35.2 0.0 4.9e-05 22.7 0.0 2.6 2 1 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO31723.1 - 0.00024 20.5 0.0 0.0088 15.3 0.0 2.5 2 1 0 2 2 2 1 Sugar-transfer associated ATP-grasp DHHC PF01529.20 KOO31724.1 - 5.3e-27 94.5 0.5 5.3e-27 94.5 0.5 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase RbpA PF13397.6 KOO31724.1 - 0.19 12.3 0.0 0.33 11.6 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase-binding protein DUF4131 PF13567.6 KOO31724.1 - 3.7 7.2 6.4 6.1 6.5 0.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) AAA_12 PF13087.6 KOO31725.1 - 9.2e-49 165.8 0.0 1.3e-48 165.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO31725.1 - 3.9e-40 138.3 0.2 2.1e-39 135.9 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOO31725.1 - 2.1e-11 43.9 10.4 2.4e-09 37.2 0.3 3.8 3 1 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 KOO31725.1 - 2.7e-06 27.3 0.2 0.58 9.8 0.1 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 KOO31725.1 - 3.9e-06 27.3 0.0 1.7e-05 25.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KOO31725.1 - 3.6e-05 23.5 0.8 0.00011 22.0 0.8 1.9 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.14 KOO31725.1 - 0.00052 19.9 0.1 0.017 15.0 0.0 2.7 2 0 0 2 2 2 1 Helicase AAA_16 PF13191.6 KOO31725.1 - 0.0013 19.1 0.8 0.0013 19.1 0.8 3.3 4 1 0 4 4 4 1 AAA ATPase domain IstB_IS21 PF01695.17 KOO31725.1 - 0.0079 15.9 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 KOO31725.1 - 0.021 15.0 0.1 0.19 11.9 0.0 2.6 3 1 0 3 3 3 0 AAA domain Phage_30_3 PF08010.11 KOO31725.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 cobW PF02492.19 KOO31725.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.9 KOO31725.1 - 0.15 11.2 0.0 0.92 8.7 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Zot PF05707.12 KOO31725.1 - 0.22 11.2 0.0 0.51 9.9 0.0 1.6 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) Ank_4 PF13637.6 KOO31726.1 - 3.8e-05 24.2 0.7 0.024 15.2 0.1 1.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO31726.1 - 0.0028 18.2 0.0 0.0063 17.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO31726.1 - 0.018 15.5 0.0 0.048 14.2 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeat Ank PF00023.30 KOO31726.1 - 0.022 15.2 0.0 0.055 13.9 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeat ResIII PF04851.15 KOO31727.1 - 6.3e-06 26.3 0.0 0.0035 17.4 0.0 3.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 KOO31727.1 - 0.0016 17.9 0.0 0.0038 16.7 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein AAA_25 PF13481.6 KOO31727.1 - 0.32 10.5 0.0 0.32 10.5 0.0 3.6 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 KOO31727.1 - 1.5 9.1 0.0 1.5 9.1 0.0 3.7 3 1 0 3 3 3 0 AAA ATPase domain Radical_SAM PF04055.21 KOO31729.1 - 5.3e-19 69.2 0.0 7.1e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 KOO31729.1 - 0.019 15.1 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain UCH PF00443.29 KOO31730.1 - 3.6e-53 180.7 0.0 4.6e-53 180.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO31730.1 - 2.1e-20 73.6 0.1 3.7e-18 66.2 0.1 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 KOO31730.1 - 0.00036 20.1 1.4 0.29 10.6 0.2 3.1 3 0 0 3 3 3 3 Ubiquitin-specific peptidase-like, SUMO isopeptidase Agenet PF05641.12 KOO31731.1 - 0.031 14.7 0.1 0.078 13.5 0.1 1.6 1 0 0 1 1 1 0 Agenet domain DUF737 PF05300.11 KOO31731.1 - 0.05 14.0 5.4 0.075 13.4 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF5384 PF17358.2 KOO31731.1 - 0.43 10.6 17.7 0.16 12.0 15.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5384) eIF3_subunit PF08597.10 KOO31731.1 - 2.4 8.0 12.3 3.7 7.4 12.3 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit ERCC4 PF02732.15 KOO31732.1 - 2.8e-07 30.9 0.0 4e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain DUF3676 PF12429.8 KOO31732.1 - 0.041 13.7 2.0 0.059 13.2 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3676) AI-2E_transport PF01594.16 KOO31733.1 - 1.2e-30 106.8 24.9 1.6e-29 103.1 24.9 2.0 1 1 0 1 1 1 1 AI-2E family transporter ATP-synt_D PF01813.17 KOO31734.1 - 7.7e-65 218.4 4.7 7.7e-65 218.4 4.7 1.8 2 0 0 2 2 2 1 ATP synthase subunit D DUF1719 PF08224.11 KOO31734.1 - 0.13 11.3 0.2 0.2 10.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1719) NGP1NT PF08153.12 KOO31735.1 - 1.1e-41 142.1 0.0 1.9e-41 141.3 0.0 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 KOO31735.1 - 1.1e-16 61.0 0.0 2.1e-14 53.5 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOO31735.1 - 9.7e-07 28.4 0.1 4.5e-06 26.3 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KOO31735.1 - 0.00017 21.5 0.0 0.00047 20.1 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 KOO31735.1 - 0.0006 19.3 0.0 0.14 11.6 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Dynamin_N PF00350.23 KOO31735.1 - 0.04 14.0 1.1 0.96 9.5 0.1 2.8 3 1 1 4 4 4 0 Dynamin family AAA_18 PF13238.6 KOO31735.1 - 0.16 12.6 0.0 0.45 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain FAE1_CUT1_RppA PF08392.12 KOO31736.1 - 3.3e-105 351.6 0.0 4.1e-105 351.2 0.0 1.1 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Chal_sti_synt_C PF02797.15 KOO31736.1 - 2.2e-11 44.0 0.0 8.5e-11 42.1 0.0 1.9 3 0 0 3 3 3 1 Chalcone and stilbene synthases, C-terminal domain ACP_syn_III_C PF08541.10 KOO31736.1 - 2.9e-10 40.2 0.0 2e-09 37.5 0.0 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_N PF00195.19 KOO31736.1 - 0.0086 15.5 0.1 0.015 14.8 0.1 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III PF08545.10 KOO31736.1 - 0.086 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 KOO31736.1 - 0.092 12.3 0.2 0.14 11.7 0.2 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain DUF179 PF02622.15 KOO31737.1 - 5e-14 52.6 0.0 7e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 DUF2470 PF10615.9 KOO31738.1 - 1.6e-05 25.5 0.0 3.7e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Pyrid_oxidase_2 PF13883.6 KOO31738.1 - 0.013 15.4 0.0 0.048 13.6 0.0 1.8 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase SH3_2 PF07653.17 KOO31739.1 - 0.12 12.1 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SH3_9 PF14604.6 KOO31739.1 - 0.17 11.8 0.0 0.55 10.1 0.0 1.9 2 0 0 2 2 2 0 Variant SH3 domain IQ PF00612.27 KOO31739.1 - 2.1 8.4 13.7 2.2 8.3 1.4 4.3 3 0 0 3 3 3 0 IQ calmodulin-binding motif IQ PF00612.27 KOO31740.1 - 4.8e-15 53.9 41.7 0.0016 18.0 0.1 7.2 7 0 0 7 7 7 6 IQ calmodulin-binding motif EF-hand_7 PF13499.6 KOO31740.1 - 1.4e-08 35.1 1.8 2.2e-08 34.4 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO31740.1 - 7.8e-08 31.7 0.0 0.0051 16.7 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO31740.1 - 3.7e-07 29.2 0.0 0.012 15.2 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO31740.1 - 8.2e-05 21.9 1.1 0.12 11.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO31740.1 - 0.00095 19.0 0.0 0.08 12.8 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair Aldo_ket_red PF00248.21 KOO31742.1 - 6.1e-27 94.6 0.2 2.7e-26 92.5 0.2 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family TniB PF05621.11 KOO31742.1 - 0.064 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein MMR_HSR1 PF01926.23 KOO31743.1 - 0.00076 19.5 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO31743.1 - 0.04 13.8 0.0 0.42 10.5 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 KOO31743.1 - 0.05 13.1 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NOG1_N PF17835.1 KOO31744.1 - 1.5e-53 181.0 0.3 1.5e-53 181.0 0.3 2.5 4 0 0 4 4 4 1 NOG1 N-terminal helical domain NOG1 PF06858.14 KOO31744.1 - 4.4e-27 93.6 1.3 5.3e-26 90.2 0.2 2.5 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 KOO31744.1 - 1.2e-18 67.2 0.0 2.8e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase NOGCT PF08155.11 KOO31744.1 - 2e-15 56.5 0.4 5.4e-15 55.1 0.4 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain FeoB_N PF02421.18 KOO31744.1 - 4.5e-12 45.8 0.1 8.9e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 KOO31744.1 - 0.00095 18.6 0.8 0.0066 15.8 0.0 2.3 2 0 0 2 2 2 1 AIG1 family GTP_EFTU PF00009.27 KOO31744.1 - 0.0016 18.0 2.0 0.014 15.0 2.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOO31744.1 - 0.0018 18.2 2.5 1.3 8.9 0.0 3.2 3 1 0 3 3 3 2 RsgA GTPase Dynamin_N PF00350.23 KOO31744.1 - 0.0099 15.9 3.1 2.9 7.9 0.0 3.4 2 1 1 3 3 3 2 Dynamin family SRPRB PF09439.10 KOO31744.1 - 0.018 14.5 0.0 0.042 13.3 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KOO31744.1 - 0.047 14.1 0.1 0.21 12.0 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain Ead_Ea22 PF13935.6 KOO31744.1 - 0.073 13.7 2.4 0.16 12.6 2.4 1.6 1 0 0 1 1 1 0 Ead/Ea22-like protein Mesd PF10185.9 KOO31744.1 - 0.08 12.9 2.9 0.16 11.9 2.9 1.5 1 0 0 1 1 1 0 Chaperone for wingless signalling and trafficking of LDL receptor Lip_prot_lig_C PF10437.9 KOO31744.1 - 0.081 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus Hypoth_Ymh PF09509.10 KOO31745.1 - 0.079 12.9 0.0 0.088 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (Hypoth_ymh) TPR_12 PF13424.6 KOO31746.1 - 8.2e-37 125.4 18.4 5.5e-12 45.8 4.7 5.2 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 KOO31746.1 - 5.8e-31 105.5 25.6 6.3e-08 32.2 0.2 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_7 PF13176.6 KOO31746.1 - 6.9e-07 28.9 17.1 0.055 13.5 0.1 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO31746.1 - 8.5e-07 28.6 8.5 0.18 12.0 0.0 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO31746.1 - 1.4e-06 27.9 3.5 0.59 10.1 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO31746.1 - 7.3e-06 25.6 3.9 7.1e-05 22.3 1.1 2.8 3 1 0 3 3 3 1 MalT-like TPR region TPR_17 PF13431.6 KOO31746.1 - 4.5e-05 23.5 0.4 3.8 8.1 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31746.1 - 0.0023 18.0 5.5 4.5 7.7 0.1 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO31746.1 - 0.082 13.6 0.0 0.082 13.6 0.0 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF630 PF04783.12 KOO31746.1 - 0.19 11.9 2.1 22 5.3 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF630) TPR_16 PF13432.6 KOO31746.1 - 0.28 11.9 18.3 0.23 12.2 0.7 5.7 3 2 3 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO31746.1 - 0.31 11.6 8.1 1.7 9.2 1.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat BSP_II PF05432.11 KOO31746.1 - 0.31 10.7 7.8 0.45 10.2 7.8 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) TPR_14 PF13428.6 KOO31746.1 - 0.61 11.1 11.7 67 4.7 0.1 5.7 4 1 1 5 5 4 0 Tetratricopeptide repeat Pox_Ag35 PF03286.14 KOO31746.1 - 1.2 8.9 5.2 2.2 8.0 5.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Ank_2 PF12796.7 KOO31747.1 - 2.6e-23 82.4 1.7 4.7e-16 59.1 0.3 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO31747.1 - 1.8e-16 60.0 3.1 1.2e-10 41.5 0.1 3.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO31747.1 - 3.2e-16 59.5 4.2 5.5e-08 33.2 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO31747.1 - 1.8e-14 52.4 1.2 8.1e-05 22.7 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO31747.1 - 2.7e-11 43.4 8.5 6.7e-06 26.3 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat JmjC PF02373.22 KOO31747.1 - 0.038 14.4 0.0 0.081 13.4 0.0 1.6 1 1 0 1 1 1 0 JmjC domain, hydroxylase SOGA PF11365.8 KOO31749.1 - 0.012 16.7 3.9 0.012 16.7 3.9 3.1 2 1 1 3 3 3 0 Protein SOGA SPOR PF05036.13 KOO31749.1 - 0.082 13.3 0.6 0.082 13.3 0.6 3.9 2 2 1 3 3 3 0 Sporulation related domain Fez1 PF06818.15 KOO31749.1 - 2.1 8.8 25.0 1.7 9.0 12.9 2.1 1 1 1 2 2 2 0 Fez1 Glyco_transf_90 PF05686.12 KOO31753.1 - 1.2e-22 80.4 0.0 2.3e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 90 NPV_P10 PF05531.12 KOO31753.1 - 0.0034 17.8 7.1 2.6 8.6 0.1 3.3 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein SKA2 PF16740.5 KOO31753.1 - 0.0058 16.4 4.4 0.0058 16.4 4.4 2.4 2 0 0 2 2 2 1 Spindle and kinetochore-associated protein 2 Dynactin_p22 PF07426.11 KOO31753.1 - 0.02 14.7 11.2 0.44 10.4 12.4 2.5 2 1 0 2 2 2 0 Dynactin subunit p22 FlaC_arch PF05377.11 KOO31753.1 - 0.022 15.1 2.0 0.022 15.1 2.0 3.3 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) PKcGMP_CC PF16808.5 KOO31753.1 - 0.024 14.5 0.7 0.024 14.5 0.7 3.7 3 1 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF2730 PF10805.8 KOO31753.1 - 0.024 14.7 10.4 0.031 14.4 3.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) Baculo_PEP_C PF04513.12 KOO31753.1 - 0.063 13.3 0.3 0.14 12.2 0.0 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF489 PF04356.12 KOO31753.1 - 0.1 12.6 10.3 1.9 8.4 0.5 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF489) RIC3 PF15361.6 KOO31753.1 - 0.19 12.1 15.1 0.074 13.5 0.9 2.7 2 1 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 XhlA PF10779.9 KOO31753.1 - 0.21 11.8 19.6 0.49 10.6 0.7 3.4 3 0 0 3 3 3 0 Haemolysin XhlA Fib_alpha PF08702.10 KOO31753.1 - 0.25 11.5 11.1 1.5 9.0 2.7 2.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.8 KOO31753.1 - 0.66 10.0 23.5 0.41 10.7 3.0 3.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF16 PF01519.16 KOO31753.1 - 0.87 10.1 14.4 7.9 7.0 0.4 3.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 FemAB PF02388.16 KOO31753.1 - 1 8.2 4.3 0.55 9.0 2.4 1.3 1 1 0 1 1 1 0 FemAB family FapA PF03961.13 KOO31753.1 - 1.5 7.4 15.6 0.052 12.2 7.2 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A Spc29 PF17082.5 KOO31753.1 - 1.6 8.5 14.4 0.28 11.0 0.4 3.4 2 1 2 4 4 4 0 Spindle Pole Component 29 ExsD PF16806.5 KOO31753.1 - 2 8.2 5.2 63 3.4 6.4 2.6 2 1 0 2 2 2 0 Antiactivator protein ExsD BLOC1_2 PF10046.9 KOO31753.1 - 2.1 8.7 13.9 6.6 7.1 0.6 3.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4795 PF16043.5 KOO31753.1 - 3.5 7.2 17.7 8.6 5.9 17.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Fez1 PF06818.15 KOO31753.1 - 3.7 8.0 13.7 13 6.2 14.1 1.7 2 0 0 2 2 1 0 Fez1 CREPT PF16566.5 KOO31753.1 - 3.8 7.7 13.4 4.4 7.5 0.3 3.3 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF1664 PF07889.12 KOO31753.1 - 4 7.5 10.8 2.6 8.1 3.2 2.9 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.7 KOO31753.1 - 4.3 7.5 27.7 0.11 12.6 15.3 2.2 1 1 1 2 2 2 0 Tropomyosin like Snapin_Pallidin PF14712.6 KOO31753.1 - 5.9 7.4 10.7 2.8 8.4 3.3 3.0 2 1 1 3 3 3 0 Snapin/Pallidin Exonuc_VII_L PF02601.15 KOO31753.1 - 6 6.3 9.9 16 4.9 9.9 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit MPS2 PF17060.5 KOO31753.1 - 7.2 5.8 10.2 0.64 9.2 3.0 2.0 1 1 1 2 2 2 0 Monopolar spindle protein 2 Occludin_ELL PF07303.13 KOO31753.1 - 7.7 7.3 8.3 2.1 9.1 2.4 2.4 1 1 0 2 2 2 0 Occludin homology domain SlyX PF04102.12 KOO31753.1 - 8 7.2 16.7 2 9.1 1.1 3.5 1 1 1 3 3 3 0 SlyX Pkinase PF00069.25 KOO31754.1 - 1.1e-46 159.3 0.0 1.9e-46 158.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31754.1 - 5.6e-27 94.6 0.0 7.3e-27 94.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO31754.1 - 5.1e-06 26.0 0.0 7.8e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO31754.1 - 0.00058 18.8 0.0 0.0035 16.2 0.0 1.9 1 1 1 2 2 2 1 Fungal protein kinase APH PF01636.23 KOO31754.1 - 0.034 14.1 8.9 0.1 12.5 0.3 3.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family IATP PF04568.12 KOO31754.1 - 0.075 13.5 0.1 0.19 12.2 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Kdo PF06293.14 KOO31754.1 - 0.22 10.8 1.5 0.37 10.1 1.5 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MHB PF16525.5 KOO31756.1 - 0.055 13.7 0.0 0.28 11.5 0.0 2.1 2 0 0 2 2 2 0 Haemophore, haem-binding AAT PF03417.16 KOO31757.1 - 1.2e-24 87.2 0.0 1.7e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Ceramidase PF05875.12 KOO31758.1 - 3.9e-07 29.8 0.0 4.2e-07 29.7 0.0 1.0 1 0 0 1 1 1 1 Ceramidase Mitoc_mL59 PF18126.1 KOO31759.1 - 6.3 7.1 13.1 1 9.7 0.5 2.6 2 1 0 2 2 2 0 Mitochondrial ribosomal protein mL59 CHAT PF12770.7 KOO31761.1 - 0.0068 15.8 0.3 0.0075 15.7 0.3 1.1 1 0 0 1 1 1 1 CHAT domain EF-hand_1 PF00036.32 KOO31761.1 - 0.015 14.8 0.0 0.034 13.7 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.6 KOO31761.1 - 0.026 14.0 0.1 0.049 13.2 0.1 1.5 1 0 0 1 1 1 0 EF hand SET PF00856.28 KOO31761.1 - 0.11 12.9 0.0 0.12 12.7 0.0 1.1 1 0 0 1 1 1 0 SET domain EF-hand_7 PF13499.6 KOO31761.1 - 0.12 12.8 0.1 0.23 11.9 0.1 1.7 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO31761.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Glyco_transf_8C PF08437.10 KOO31761.1 - 0.17 12.0 0.2 0.29 11.3 0.2 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 8 C-terminal HEAT_2 PF13646.6 KOO31762.1 - 2.5e-07 31.0 27.0 0.048 14.1 3.9 7.3 5 2 3 8 8 8 5 HEAT repeats HEAT_EZ PF13513.6 KOO31762.1 - 2.9e-07 30.9 44.6 0.00017 22.0 0.5 9.7 9 2 2 11 11 11 4 HEAT-like repeat HEAT PF02985.22 KOO31762.1 - 3.1e-06 27.0 21.2 0.89 10.0 0.1 9.4 9 0 0 9 9 9 2 HEAT repeat Cnd1 PF12717.7 KOO31762.1 - 1.4e-05 25.2 1.6 0.0093 16.0 0.0 4.3 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Tti2 PF10521.9 KOO31762.1 - 4.8e-05 23.0 0.3 9.6 5.6 0.0 5.5 5 1 1 6 6 6 1 Tti2 family Adaptin_N PF01602.20 KOO31762.1 - 7.7e-05 21.4 1.1 0.0065 15.1 0.1 2.9 3 0 0 3 3 3 1 Adaptin N terminal region IFRD PF05004.13 KOO31762.1 - 0.0056 15.8 0.4 0.076 12.1 0.0 3.0 4 0 0 4 4 4 1 Interferon-related developmental regulator (IFRD) ParcG PF10274.9 KOO31762.1 - 0.006 16.7 0.0 0.026 14.7 0.1 1.9 2 0 0 2 2 2 1 Parkin co-regulated protein RTP1_C1 PF10363.9 KOO31762.1 - 0.015 15.4 1.2 13 6.0 0.3 4.0 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_N PF14500.6 KOO31762.1 - 0.026 14.1 0.3 3.5 7.1 0.2 3.1 3 1 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II Ribosomal_S30AE PF02482.19 KOO31763.1 - 2.9e-12 47.2 1.1 4e-12 46.7 1.1 1.2 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein Borrelia_REV PF03978.13 KOO31763.1 - 0.021 14.8 1.2 0.025 14.5 1.2 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein CagA PF03507.13 KOO31763.1 - 0.039 13.9 0.0 0.046 13.7 0.0 1.3 1 0 0 1 1 1 0 CagA exotoxin DFF-C PF09033.10 KOO31763.1 - 0.04 13.8 0.0 0.058 13.3 0.0 1.2 1 0 0 1 1 1 0 DNA Fragmentation factor 45kDa, C terminal domain Cortex-I_coil PF09304.10 KOO31763.1 - 0.079 13.2 3.2 0.083 13.1 2.3 1.6 1 1 1 2 2 2 0 Cortexillin I, coiled coil Pkinase PF00069.25 KOO31764.1 - 7.6e-58 195.9 0.0 1.1e-57 195.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31764.1 - 6.5e-39 133.8 0.0 9.5e-39 133.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO31764.1 - 0.0007 19.0 0.0 0.0019 17.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO31764.1 - 0.035 12.9 0.2 0.082 11.7 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase GreA_GreB PF01272.19 KOO31764.1 - 0.06 13.2 0.1 7.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Transcription elongation factor, GreA/GreB, C-term DUF2431 PF10354.9 KOO31765.1 - 1.5e-08 35.1 0.0 2.2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) PEGSRP PF07623.11 KOO31765.1 - 0.021 14.6 0.1 0.054 13.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1584) Tudor-knot PF11717.8 KOO31766.1 - 0.06 13.3 2.8 15 5.6 2.6 2.6 2 1 0 2 2 2 0 RNA binding activity-knot of a chromodomain Pkinase_Tyr PF07714.17 KOO31767.1 - 2.7e-35 121.9 0.0 6.5e-35 120.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO31767.1 - 3.9e-33 114.9 0.0 6.5e-33 114.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain FTA2 PF13095.6 KOO31767.1 - 0.017 14.8 0.0 2.1 7.9 0.0 2.7 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Mito_carr PF00153.27 KOO31768.1 - 1.3e-22 79.5 3.1 3.5e-18 65.3 0.2 2.9 2 1 0 2 2 2 2 Mitochondrial carrier protein Sterol_MT_C PF08498.10 KOO31768.1 - 0.019 15.3 0.1 9.4 6.6 0.0 2.5 2 0 0 2 2 2 0 Sterol methyltransferase C-terminal Ost5 PF05251.12 KOO31768.1 - 0.095 13.0 0.6 0.26 11.6 0.1 2.1 1 1 1 2 2 2 0 Oligosaccharyltransferase subunit 5 SHIPPO-rpt PF07004.12 KOO31769.1 - 5.4e-05 23.9 8.2 0.65 11.0 0.0 5.1 5 0 0 5 5 5 3 Sperm-tail PG-rich repeat RPA_C PF08784.11 KOO31770.1 - 1.7e-08 35.0 0.2 6.4e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 KOO31770.1 - 7.7e-08 32.2 0.0 1.3e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 KOO31770.1 - 1.7e-05 24.6 0.0 3.5e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 Ten1_2 PF15490.6 KOO31770.1 - 0.074 12.8 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit Keratin_2_head PF16208.5 KOO31770.1 - 0.087 13.0 18.3 0.15 12.2 18.3 1.3 1 0 0 1 1 1 0 Keratin type II head ABC_tran PF00005.27 KOO31771.1 - 1.4e-34 119.5 0.0 3e-34 118.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOO31771.1 - 1.7e-27 96.8 12.7 2.8e-27 96.1 12.7 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 KOO31771.1 - 3.1e-06 26.8 2.3 4.5e-05 23.0 0.2 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO31771.1 - 0.00019 21.9 0.0 0.00039 20.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO31771.1 - 0.00065 20.0 0.1 0.0041 17.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 KOO31771.1 - 0.00071 20.0 0.2 0.027 14.9 0.2 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 KOO31771.1 - 0.0025 17.5 0.0 0.006 16.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain IstB_IS21 PF01695.17 KOO31771.1 - 0.0034 17.1 0.2 7.2 6.3 0.0 3.1 3 0 0 3 3 3 1 IstB-like ATP binding protein Zeta_toxin PF06414.12 KOO31771.1 - 0.01 15.2 0.0 0.027 13.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 KOO31771.1 - 0.014 15.3 0.1 0.03 14.2 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase DUF87 PF01935.17 KOO31771.1 - 0.018 15.2 0.4 0.075 13.1 0.4 2.0 1 1 0 1 1 1 0 Helicase HerA, central domain AAA_25 PF13481.6 KOO31771.1 - 0.038 13.6 0.1 0.46 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KOO31771.1 - 0.042 14.0 0.0 0.096 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO31771.1 - 0.049 13.5 0.1 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA_15 PF13175.6 KOO31771.1 - 0.093 12.4 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain DUF815 PF05673.13 KOO31771.1 - 0.13 11.4 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 KOO31771.1 - 0.17 11.9 0.1 13 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 KOO31771.1 - 0.2 11.6 0.5 6.2 6.7 0.0 2.2 2 0 0 2 2 2 0 NTPase SbcCD_C PF13558.6 KOO31771.1 - 2.2 8.6 5.2 2.7 8.3 0.5 3.2 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit TraL PF07178.11 KOO31771.1 - 6.1 7.4 5.8 15 6.1 0.0 3.4 3 0 0 3 3 3 0 TraL protein SAA PF00277.18 KOO31772.1 - 0.011 16.2 0.6 0.026 15.0 0.6 1.6 2 0 0 2 2 2 0 Serum amyloid A protein ECR1_N PF14382.6 KOO31772.1 - 0.12 12.2 0.0 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 Exosome complex exonuclease RRP4 N-terminal region Acid_PPase PF12689.7 KOO31774.1 - 8.3e-19 68.1 0.0 2.2e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 Acid Phosphatase Ribonuclease_3 PF00636.26 KOO31774.1 - 3.4e-17 63.0 0.0 2.3e-10 41.0 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III domain DEAD PF00270.29 KOO31774.1 - 2.2e-14 53.6 0.0 5.7e-14 52.3 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO31774.1 - 4.5e-14 52.8 0.0 8.1e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOO31774.1 - 9.9e-14 51.6 0.0 3.3e-13 49.9 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ribonucleas_3_3 PF14622.6 KOO31774.1 - 3.2e-05 24.1 0.0 0.18 12.0 0.0 3.4 3 0 0 3 3 3 2 Ribonuclease-III-like Dicer_dimer PF03368.14 KOO31774.1 - 0.0043 17.2 0.0 0.018 15.2 0.0 2.0 1 0 0 1 1 1 1 Dicer dimerisation domain AAA_22 PF13401.6 KOO31774.1 - 0.012 15.9 0.0 0.067 13.5 0.0 2.3 1 0 0 1 1 1 0 AAA domain CS PF04969.16 KOO31775.1 - 4.5e-10 40.4 0.0 7.5e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 CS domain fn3 PF00041.21 KOO31775.1 - 3.5e-06 27.3 3.5 9.3e-05 22.7 1.1 3.1 2 2 0 2 2 2 1 Fibronectin type III domain Branch PF02485.21 KOO31776.1 - 0.045 13.3 0.0 0.049 13.1 0.0 1.1 1 0 0 1 1 1 0 Core-2/I-Branching enzyme YABBY PF04690.13 KOO31779.1 - 2.1e-10 41.4 0.1 2.6e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 YABBY protein HMG_box PF00505.19 KOO31779.1 - 1.8e-05 25.0 0.7 2.8e-05 24.5 0.0 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO31779.1 - 6.4e-05 23.5 0.4 0.00019 21.9 0.0 1.8 2 0 0 2 2 2 1 HMG-box domain Ccdc124 PF06244.12 KOO31779.1 - 0.068 13.7 0.3 0.11 13.1 0.3 1.4 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 124 /Oxs1 MFS_2 PF13347.6 KOO31784.1 - 9e-13 47.6 3.7 1e-12 47.3 3.7 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein Arm PF00514.23 KOO31785.1 - 5.1e-154 496.4 150.0 5.5e-06 26.2 0.5 43.8 44 1 1 45 45 43 39 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO31785.1 - 1.9e-16 59.9 9.2 0.0028 17.6 0.2 11.4 13 0 0 13 13 10 4 Spinocerebellar ataxia type 10 protein domain EF-hand_1 PF00036.32 KOO31785.1 - 4e-09 35.4 0.1 0.0043 16.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO31785.1 - 9.9e-09 34.3 0.6 0.0021 17.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31785.1 - 3.5e-08 32.7 0.1 0.0024 17.7 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO31785.1 - 4.2e-07 30.3 0.0 0.052 14.0 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair Arm_2 PF04826.13 KOO31785.1 - 4.5e-07 29.6 9.4 0.14 11.6 1.1 8.3 3 2 4 8 8 8 2 Armadillo-like EF-hand_8 PF13833.6 KOO31785.1 - 5.8e-07 29.3 0.0 1.4e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair DUF5578 PF17741.1 KOO31785.1 - 1.1e-05 25.0 23.4 0.096 12.1 0.0 9.4 8 3 2 10 10 10 2 Family of unknown function (DUF5578) Adaptin_N PF01602.20 KOO31785.1 - 0.00042 19.0 5.8 0.23 10.0 0.3 3.7 3 1 0 3 3 3 2 Adaptin N terminal region DUF3361 PF11841.8 KOO31785.1 - 0.00047 20.1 11.0 28 4.6 0.0 8.0 7 0 0 7 7 7 0 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 KOO31785.1 - 0.00068 19.7 4.3 1.1 9.4 0.1 6.2 7 0 0 7 7 6 1 V-ATPase subunit H RICTOR_N PF14664.6 KOO31785.1 - 0.001 18.2 11.9 7.5 5.4 0.1 8.8 10 1 1 11 11 11 1 Rapamycin-insensitive companion of mTOR, N-term CLASP_N PF12348.8 KOO31785.1 - 0.002 17.8 1.1 4.2 6.9 0.0 3.7 2 1 0 2 2 2 2 CLASP N terminal Cnd1 PF12717.7 KOO31785.1 - 0.002 18.2 4.9 9.6 6.2 0.0 7.1 6 2 3 9 9 9 1 non-SMC mitotic condensation complex subunit 1 KAP PF05804.12 KOO31785.1 - 0.0059 14.8 0.0 2 6.4 0.0 4.6 7 0 0 7 7 7 1 Kinesin-associated protein (KAP) RTTN_N PF14726.6 KOO31785.1 - 0.01 16.6 0.1 22 5.9 0.0 3.8 3 0 0 3 3 2 0 Rotatin, an armadillo repeat protein, centriole functioning DUF4704 PF15787.5 KOO31785.1 - 0.022 14.0 0.9 7.5 5.7 0.1 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4704) GETHR PF05671.11 KOO31786.1 - 1.5e-05 24.2 3.5 3e-05 23.3 3.5 1.5 1 0 0 1 1 1 1 GETHR pentapeptide repeat (5 copies) DUF4235 PF14019.6 KOO31786.1 - 0.025 14.7 0.0 0.064 13.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4235) RF-1 PF00472.20 KOO31787.1 - 3.8e-06 26.8 3.6 5e-06 26.4 3.6 1.2 1 0 0 1 1 1 1 RF-1 domain Pkinase PF00069.25 KOO31788.1 - 1.8e-69 234.0 0.0 2.2e-69 233.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31788.1 - 6.7e-30 104.2 0.0 8.5e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO31788.1 - 4.9e-06 26.1 0.0 7.4e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO31788.1 - 2.5e-05 24.3 1.8 0.00013 21.9 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO31788.1 - 0.0001 21.8 0.0 0.0017 17.7 0.0 2.3 1 1 0 2 2 2 1 Kinase-like Choline_kinase PF01633.20 KOO31788.1 - 0.0012 18.5 0.0 0.0018 17.9 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 KOO31788.1 - 0.0013 17.5 0.0 0.002 17.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 KOO31788.1 - 0.0041 16.8 0.0 0.87 9.2 0.0 2.1 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 DUF1679 PF07914.11 KOO31788.1 - 0.027 13.4 0.0 0.043 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) RIO1 PF01163.22 KOO31788.1 - 0.052 13.2 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 KOO31788.1 - 0.25 10.9 0.0 0.4 10.2 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF4431 PF14485.6 KOO31789.1 - 0.18 11.6 0.0 0.44 10.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4431) Nup88 PF10168.9 KOO31790.1 - 0.4 8.4 11.8 0.42 8.4 11.8 1.1 1 0 0 1 1 1 0 Nuclear pore component DUF4407 PF14362.6 KOO31790.1 - 8.7 5.6 46.5 11 5.3 33.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) BCDHK_Adom3 PF10436.9 KOO31791.1 - 3.1e-13 49.9 0.2 4.4e-13 49.4 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF563 PF04577.14 KOO31795.1 - 1.4e-11 44.9 0.0 2.4e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DHDPS PF00701.22 KOO31796.1 - 4.9e-24 84.5 0.0 6.4e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Amidohydro_2 PF04909.14 KOO31796.1 - 0.055 13.2 0.1 0.47 10.2 0.0 2.0 2 0 0 2 2 2 0 Amidohydrolase Ank_2 PF12796.7 KOO31797.1 - 4.5e-09 36.8 0.2 9.3e-09 35.8 0.2 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO31797.1 - 1.1e-07 32.2 0.4 8.2e-07 29.5 0.2 2.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO31797.1 - 2.4e-06 27.7 0.3 0.00026 21.2 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO31797.1 - 5.4e-06 26.6 0.3 0.011 16.1 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO31797.1 - 3.1e-05 24.0 0.3 0.12 13.0 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat CAF1C_H4-bd PF12265.8 KOO31798.1 - 2.7e-29 101.2 0.2 1.5e-28 98.8 0.1 2.4 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 KOO31798.1 - 7.4e-26 89.9 12.8 2.8e-06 28.0 0.0 6.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO31798.1 - 0.00017 21.8 1.9 0.092 13.1 0.0 4.1 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO31798.1 - 0.00056 19.8 0.2 0.015 15.2 0.0 2.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A DUF1995 PF09353.10 KOO31799.1 - 1.2e-40 139.6 0.0 1.6e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) DUF4358 PF14270.6 KOO31800.1 - 0.11 12.8 0.5 1.8 8.9 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) Aminotran_3 PF00202.21 KOO31801.1 - 5.9e-109 364.4 0.4 6.8e-109 364.2 0.4 1.0 1 0 0 1 1 1 1 Aminotransferase class-III zf-C2H2 PF00096.26 KOO31802.1 - 1.5e-29 100.8 58.5 6.7e-05 23.1 2.4 7.4 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO31802.1 - 5.4e-28 96.1 55.6 4.2e-06 27.0 1.3 8.1 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO31802.1 - 5.7e-20 70.3 47.9 0.0085 16.9 1.2 7.6 7 0 0 7 7 7 6 C2H2-type zinc finger FANCL_C PF11793.8 KOO31802.1 - 0.086 13.0 0.7 0.086 13.0 0.7 7.8 2 2 6 8 8 8 0 FANCL C-terminal domain CHORD PF04968.12 KOO31802.1 - 0.33 11.7 36.7 5.9 7.7 0.5 6.5 1 1 5 6 6 6 0 CHORD zf-C2H2_aberr PF17017.5 KOO31802.1 - 1 9.4 23.3 1.5 8.9 1.8 5.7 3 2 2 5 5 5 0 Aberrant zinc-finger zf-LYAR PF08790.11 KOO31802.1 - 2.3 8.2 19.4 5 7.1 0.4 6.0 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.6 KOO31802.1 - 2.3 8.3 44.3 2.7 8.1 0.4 7.2 7 0 0 7 7 7 0 C2H2-type zinc finger Hydin_ADK PF17213.3 KOO31806.1 - 0.042 14.1 3.5 0.1 12.9 3.5 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF179 PF02622.15 KOO31807.1 - 5.8e-24 84.9 0.0 1e-23 84.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 TPR_2 PF07719.17 KOO31808.1 - 2.3e-21 74.1 18.4 8.4e-06 25.5 0.3 6.0 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO31808.1 - 4.1e-21 73.9 7.7 1.9e-07 30.6 0.2 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO31808.1 - 2.6e-12 46.2 3.0 0.0017 18.0 0.4 4.3 3 1 1 4 4 4 4 TPR repeat TPR_12 PF13424.6 KOO31808.1 - 4e-11 43.0 18.7 0.0022 18.2 3.4 5.5 3 2 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO31808.1 - 6e-11 41.6 1.8 0.098 12.7 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO31808.1 - 2.2e-09 36.8 11.3 0.0024 18.0 0.1 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO31808.1 - 8.7e-08 31.8 14.1 0.29 11.1 0.2 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO31808.1 - 1.7e-07 31.7 9.8 9.4e-06 26.2 2.4 5.3 4 1 0 4 4 3 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO31808.1 - 3.3e-07 30.3 0.4 0.00021 21.3 0.1 4.0 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 KOO31808.1 - 1.9e-05 24.7 2.3 1.9e-05 24.7 2.3 4.8 3 3 3 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO31808.1 - 0.00012 22.6 4.9 0.012 16.4 0.6 7.3 2 2 5 7 7 6 3 Tetratricopeptide repeat MIT PF04212.18 KOO31808.1 - 0.0051 16.9 2.7 0.55 10.3 0.2 3.6 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 KOO31808.1 - 0.018 15.5 27.8 0.11 13.0 2.3 5.3 3 2 3 6 6 5 0 Tetratricopeptide repeat BTAD PF03704.17 KOO31808.1 - 0.035 14.5 0.7 0.035 14.5 0.7 4.9 2 1 1 4 4 3 0 Bacterial transcriptional activator domain SHNi-TPR PF10516.9 KOO31808.1 - 0.04 13.4 2.5 8.7 5.9 0.1 4.2 5 0 0 5 5 5 0 SHNi-TPR DUF3856 PF12968.7 KOO31808.1 - 0.09 12.8 15.1 0.16 12.1 0.7 4.8 3 2 0 3 3 3 0 Domain of Unknown Function (DUF3856) TPR_4 PF07721.14 KOO31808.1 - 0.22 12.2 0.1 0.22 12.2 0.1 7.2 7 0 0 7 7 6 0 Tetratricopeptide repeat TFIIA PF03153.13 KOO31808.1 - 0.26 11.2 8.3 0.31 11.0 8.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.10 KOO31808.1 - 1.3 7.6 5.0 1.5 7.4 5.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MAS20 PF02064.15 KOO31808.1 - 3.8 7.6 0.0 3.8 7.6 0.0 3.6 2 1 1 3 3 1 0 MAS20 protein import receptor LRR_6 PF13516.6 KOO31809.1 - 4.1e-48 157.4 35.0 0.00016 21.5 0.0 11.6 11 0 0 11 11 11 9 Leucine Rich repeat LRR_4 PF12799.7 KOO31809.1 - 6.1e-11 42.4 2.5 0.36 11.3 0.0 7.6 6 1 2 8 8 8 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO31809.1 - 0.00019 21.6 0.0 1.3e+02 3.7 0.0 7.0 9 0 0 9 9 9 0 Leucine Rich Repeat SpoU_sub_bind PF08032.12 KOO31809.1 - 0.014 15.7 8.9 24 5.3 0.0 6.1 6 0 0 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding RHH_7 PF16777.5 KOO31809.1 - 0.019 15.3 0.0 2.4e+02 2.2 0.0 5.4 6 2 1 7 7 7 0 Transcriptional regulator, RHH-like, CopG HOASN PF14515.6 KOO31809.1 - 0.19 12.1 28.9 17 5.9 0.1 8.7 2 1 8 10 10 10 0 Haem-oxygenase-associated N-terminal helices CoatB PF10389.9 KOO31809.1 - 5.9 6.8 20.0 18 5.2 0.5 6.1 5 2 1 6 6 6 0 Bacteriophage coat protein B CbiG_N PF11760.8 KOO31809.1 - 7.2 6.7 33.1 2 8.5 1.8 7.6 7 2 1 8 8 8 0 Cobalamin synthesis G N-terminal ABC_tran PF00005.27 KOO31810.1 - 8.6e-25 87.8 0.0 1.5e-24 87.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOO31810.1 - 1.4e-11 44.6 2.5 3.2e-11 43.4 1.7 1.8 1 1 1 2 2 2 1 ABC transporter transmembrane region AAA_29 PF13555.6 KOO31810.1 - 0.0008 19.1 0.1 0.005 16.5 0.1 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO31810.1 - 0.0047 17.2 0.1 0.038 14.3 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 KOO31810.1 - 0.0071 16.1 0.6 0.1 12.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 KOO31810.1 - 0.038 13.4 0.7 2.4 7.5 0.0 2.2 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO31810.1 - 0.095 13.1 7.0 0.035 14.5 1.9 2.7 3 1 0 3 3 3 0 AAA ATPase domain AAA_19 PF13245.6 KOO31810.1 - 0.14 12.5 0.0 4.3 7.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 KOO31810.1 - 0.21 11.3 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Transglycosylas PF06737.14 KOO31811.1 - 0.014 16.0 0.0 0.035 14.8 0.0 1.6 1 0 0 1 1 1 0 Transglycosylase-like domain DNA_methylase PF00145.17 KOO31811.1 - 0.18 11.1 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase LRV PF01816.17 KOO31811.1 - 7.7 7.1 10.4 4.1 8.0 2.0 3.4 2 1 0 2 2 2 0 Leucine rich repeat variant PP2C PF00481.21 KOO31813.1 - 4.1e-52 177.4 0.0 5.2e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C Metal_CEHH PF14455.6 KOO31813.1 - 0.092 12.4 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Predicted metal binding domain Ank_2 PF12796.7 KOO31814.1 - 6.2e-43 145.3 7.6 9.3e-13 48.6 0.4 5.5 2 2 1 5 5 5 5 Ankyrin repeats (3 copies) VPS13_C PF16909.5 KOO31814.1 - 7.8e-29 100.7 0.6 5.7e-24 84.9 0.0 2.6 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Ank_4 PF13637.6 KOO31814.1 - 2.9e-28 97.9 11.5 2.1e-09 37.7 0.2 7.2 5 2 4 9 9 8 7 Ankyrin repeats (many copies) Chorein_N PF12624.7 KOO31814.1 - 1.7e-23 82.9 0.0 3.8e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 Ank PF00023.30 KOO31814.1 - 1e-21 76.3 28.2 0.0021 18.4 0.1 11.0 10 1 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 KOO31814.1 - 4.2e-21 74.7 18.9 2e-06 28.0 0.2 8.7 4 3 5 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO31814.1 - 5.9e-20 69.2 14.2 0.024 15.2 0.0 10.0 9 0 0 9 9 9 4 Ankyrin repeat EF-hand_7 PF13499.6 KOO31814.1 - 5.3e-07 30.0 0.0 2.2e-06 28.0 0.0 2.1 2 0 0 2 2 1 1 EF-hand domain pair SHR-BD PF06650.12 KOO31814.1 - 1.3e-06 28.0 0.0 0.0027 17.1 0.0 3.1 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 EF-hand_1 PF00036.32 KOO31814.1 - 1.8e-06 27.0 0.0 0.0033 16.9 0.0 2.6 2 0 0 2 2 2 2 EF hand ATG_C PF09333.11 KOO31814.1 - 1e-05 25.8 0.2 6.4e-05 23.2 0.1 2.6 2 0 0 2 2 1 1 Autophagy-related protein C terminal domain EF-hand_5 PF13202.6 KOO31814.1 - 1.7e-05 24.1 0.1 7.6e-05 22.0 0.0 2.1 2 0 0 2 2 2 1 EF hand PH PF00169.29 KOO31814.1 - 5e-05 23.8 0.0 0.00015 22.2 0.0 1.8 2 0 0 2 2 1 1 PH domain EF-hand_6 PF13405.6 KOO31814.1 - 0.00066 19.4 0.0 0.069 13.1 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain VPS13 PF16908.5 KOO31814.1 - 0.0085 15.9 1.0 6.2 6.5 1.7 3.3 2 1 1 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal Glyoxalase_4 PF13669.6 KOO31814.1 - 0.016 15.5 0.2 1.1 9.6 0.1 2.9 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GRAM PF02893.20 KOO31814.1 - 0.026 14.4 0.0 0.98 9.3 0.0 2.4 2 0 0 2 2 2 0 GRAM domain Apt1 PF10351.9 KOO31814.1 - 0.063 12.1 0.2 0.21 10.4 0.0 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain zf-C3HC4_3 PF13920.6 KOO31815.1 - 0.29 11.0 5.1 0.32 10.9 2.6 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rotamase PF00639.21 KOO31816.1 - 4.2e-19 69.3 0.3 1.5e-11 45.1 0.1 2.2 1 1 1 2 2 2 2 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOO31816.1 - 2.3e-15 57.2 0.8 5.3e-10 39.9 0.3 2.4 1 1 1 2 2 2 2 PPIC-type PPIASE domain Rotamase_2 PF13145.6 KOO31816.1 - 0.0016 19.3 0.3 0.005 17.7 0.3 1.7 1 1 0 1 1 1 1 PPIC-type PPIASE domain SNase PF00565.17 KOO31819.1 - 4e-57 191.3 0.0 9.9e-17 61.4 0.0 5.2 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 KOO31819.1 - 3.4e-22 78.7 0.0 6e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 Tudor domain Thioredoxin_14 PF18402.1 KOO31819.1 - 0.058 13.3 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Cnd1 PF12717.7 KOO31820.1 - 6.7e-31 107.5 0.0 9.4e-27 94.0 0.0 3.6 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 KOO31820.1 - 7e-12 45.5 0.0 7e-12 45.5 0.0 2.3 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 KOO31820.1 - 8.1e-08 31.9 0.5 0.82 10.1 0.2 6.0 5 0 0 5 5 5 2 HEAT repeat Cnd3 PF12719.7 KOO31820.1 - 0.00024 20.4 0.1 0.0028 16.9 0.0 2.6 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Adaptin_N PF01602.20 KOO31820.1 - 0.00033 19.3 0.1 0.06 11.9 0.3 3.5 3 1 0 4 4 4 1 Adaptin N terminal region SAPS PF04499.15 KOO31820.1 - 0.015 14.1 2.9 0.25 10.1 1.0 2.7 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein mRNA_stabil PF13929.6 KOO31820.1 - 0.033 13.2 0.0 0.065 12.2 0.0 1.4 1 0 0 1 1 1 0 mRNA stabilisation PAP_fibrillin PF04755.12 KOO31821.1 - 1.1e-08 35.2 0.0 2.3e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 PAP_fibrillin Exostosin PF03016.15 KOO31822.1 - 8e-06 25.3 1.9 4.4e-05 22.8 0.0 2.6 2 1 0 2 2 2 1 Exostosin family EGF_2 PF07974.13 KOO31822.1 - 0.0049 17.2 13.5 0.012 16.0 13.5 1.7 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 KOO31822.1 - 0.041 13.9 9.2 0.086 12.9 9.2 1.6 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 KOO31822.1 - 0.61 10.8 8.3 1.8 9.3 8.3 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.27 KOO31822.1 - 0.91 9.9 8.8 2.5 8.5 8.8 1.7 1 0 0 1 1 1 0 EGF-like domain ANAPC4_WD40 PF12894.7 KOO31823.1 - 6e-12 45.7 0.8 0.013 15.8 0.1 5.4 3 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 KOO31823.1 - 2.3e-07 30.8 0.1 0.00049 20.0 0.0 3.9 3 1 1 4 4 4 2 Region in Clathrin and VPS WD40 PF00400.32 KOO31823.1 - 9.6e-07 29.4 2.4 0.025 15.4 0.0 6.0 6 0 0 6 6 6 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 KOO31823.1 - 0.00019 20.6 9.6 0.012 14.7 0.0 3.4 2 1 1 3 3 3 2 Coatomer WD associated region TPR_2 PF07719.17 KOO31823.1 - 0.025 14.7 16.7 1.2 9.4 0.6 7.1 6 1 0 6 6 6 0 Tetratricopeptide repeat PD40 PF07676.12 KOO31823.1 - 0.035 14.1 0.4 2.7 8.1 0.4 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat eIF2A PF08662.11 KOO31823.1 - 0.052 13.4 0.1 0.22 11.4 0.1 2.0 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A zinc_ribbon_15 PF17032.5 KOO31823.1 - 0.064 14.0 1.9 0.49 11.2 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon family TPR_1 PF00515.28 KOO31823.1 - 0.073 12.9 6.7 5.5 7.0 0.4 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO31823.1 - 0.084 13.2 7.9 1.2 9.5 0.1 4.3 3 1 0 3 3 3 0 Tetratricopeptide repeat Chlam_OMP3 PF03503.13 KOO31823.1 - 0.17 12.2 3.7 0.51 10.7 3.7 1.8 1 0 0 1 1 1 0 Chlamydia cysteine-rich outer membrane protein 3 DZR PF12773.7 KOO31823.1 - 0.32 11.1 11.5 11 6.2 11.5 2.6 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 KOO31823.1 - 0.4 10.4 6.4 0.66 9.8 3.8 2.5 2 0 0 2 2 2 0 zinc-ribbon domain PPR PF01535.20 KOO31823.1 - 2 8.8 6.2 2 8.8 0.2 4.0 5 0 0 5 5 2 0 PPR repeat Catalase-rel PF06628.12 KOO31824.1 - 0.044 14.0 0.0 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 Catalase-related immune-responsive TruB_C PF09142.11 KOO31824.1 - 1 9.2 6.3 8.1 6.3 0.1 2.4 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal SecY PF00344.20 KOO31825.1 - 5.6e-75 252.4 8.3 7.1e-75 252.1 8.3 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 KOO31825.1 - 2.8e-16 59.1 0.0 1e-15 57.3 0.0 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p Pkinase PF00069.25 KOO31826.1 - 4.2e-58 196.8 0.0 5.2e-58 196.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31826.1 - 1.6e-35 122.6 0.0 1.9e-35 122.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO31826.1 - 1.2e-05 24.8 0.0 0.023 14.0 0.0 2.5 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 KOO31826.1 - 9.5e-05 21.3 0.0 0.00056 18.8 0.0 1.8 1 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KOO31826.1 - 0.036 14.0 0.1 0.062 13.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO31826.1 - 0.04 13.3 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF35_N PF12172.8 KOO31826.1 - 0.14 12.0 0.9 0.39 10.6 0.9 1.7 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Dcc1 PF09724.9 KOO31827.1 - 4.2e-71 240.0 0.0 4.9e-71 239.8 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 NACHT PF05729.12 KOO31828.1 - 0.00011 22.1 0.1 0.00034 20.6 0.1 1.9 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 KOO31828.1 - 0.0017 18.0 0.4 0.0037 16.8 0.4 1.5 1 0 0 1 1 1 1 AAA domain RRM_1 PF00076.22 KOO31828.1 - 0.0082 15.9 0.0 0.02 14.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_16 PF13191.6 KOO31828.1 - 0.2 12.0 5.2 0.054 13.9 0.6 2.3 2 0 0 2 2 2 0 AAA ATPase domain DUF1863 PF08937.11 KOO31829.1 - 0.033 14.5 0.0 0.76 10.1 0.0 2.4 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) TIR_2 PF13676.6 KOO31829.1 - 0.058 14.0 0.0 0.12 13.0 0.0 1.6 1 0 0 1 1 1 0 TIR domain Spore_YtrH PF14034.6 KOO31829.1 - 0.11 12.7 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Sporulation protein YtrH ERp29 PF07749.12 KOO31829.1 - 0.72 10.8 6.9 2.9 8.8 6.9 2.0 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain TRAM_LAG1_CLN8 PF03798.16 KOO31830.1 - 8.7e-12 45.2 8.6 1.1e-11 44.8 8.6 1.2 1 0 0 1 1 1 1 TLC domain SAP PF02037.27 KOO31831.1 - 8.5e-09 35.0 2.3 2.5e-08 33.5 2.3 1.8 1 0 0 1 1 1 1 SAP domain Arm PF00514.23 KOO31831.1 - 0.065 13.3 0.1 0.66 10.1 0.0 2.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Chromo PF00385.24 KOO31832.1 - 1.8e-12 46.9 0.9 5.7e-12 45.3 0.9 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ubiquitin PF00240.23 KOO31832.1 - 0.0031 17.2 0.4 0.0089 15.8 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family Sigma70_r4_2 PF08281.12 KOO31832.1 - 0.014 15.0 0.0 3.3 7.4 0.1 3.2 3 0 0 3 3 3 0 Sigma-70, region 4 CutC PF03932.14 KOO31832.1 - 0.04 13.4 0.0 0.44 10.0 0.0 2.3 2 0 0 2 2 2 0 CutC family Mtf2_C PF14061.6 KOO31832.1 - 0.042 14.0 0.1 0.097 12.8 0.1 1.6 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 HTH_10 PF04967.12 KOO31832.1 - 0.19 11.5 2.8 0.15 11.9 0.3 2.1 2 0 0 2 2 2 0 HTH DNA binding domain DNA_pol_viral_C PF00336.18 KOO31833.1 - 0.0029 17.1 0.0 0.004 16.6 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase (viral) C-terminal domain Herpes_UL6 PF01763.16 KOO31834.1 - 0.11 11.0 0.1 0.15 10.6 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like GvpG PF05120.12 KOO31834.1 - 0.31 11.1 8.2 5.9 7.0 0.1 3.7 4 0 0 4 4 4 0 Gas vesicle protein G CheR PF01739.18 KOO31835.1 - 3.5e-09 36.4 0.0 1e-07 31.6 0.0 2.3 1 1 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_25 PF13649.6 KOO31835.1 - 0.0093 16.6 0.0 0.027 15.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain RTX PF02382.15 KOO31835.1 - 0.17 11.5 0.1 0.25 11.0 0.1 1.1 1 0 0 1 1 1 0 N-terminal domain in RTX protein FlgM PF04316.13 KOO31835.1 - 1.7 9.1 4.4 13 6.3 0.2 3.1 3 0 0 3 3 3 0 Anti-sigma-28 factor, FlgM T2SSF PF00482.23 KOO31835.1 - 7.5 6.5 7.9 5.4 7.0 0.1 2.9 2 1 1 3 3 3 0 Type II secretion system (T2SS), protein F P34-Arc PF04045.14 KOO31837.1 - 4.6e-46 157.5 0.0 6.2e-46 157.0 0.0 1.2 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc UPF0730 PF15827.5 KOO31837.1 - 0.23 11.2 0.4 0.55 10.0 0.4 1.6 1 0 0 1 1 1 0 UPF0730 unknown protein family IF-2B PF01008.17 KOO31839.1 - 0.0068 15.7 0.1 0.0079 15.4 0.1 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Peptidase_Mx PF15887.5 KOO31840.1 - 0.16 11.3 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase Aha1_N PF09229.11 KOO31841.1 - 1.5e-05 25.2 0.0 4.6e-05 23.7 0.0 1.9 1 1 1 2 2 2 1 Activator of Hsp90 ATPase, N-terminal STI1 PF17830.1 KOO31841.1 - 1.7e-05 24.7 0.0 2.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 STI1 domain NUDE_C PF04880.13 KOO31841.1 - 0.0048 17.4 0.6 0.01 16.3 0.6 1.5 1 0 0 1 1 1 1 NUDE protein, C-terminal conserved region TPR_1 PF00515.28 KOO31841.1 - 0.0057 16.4 0.3 9 6.3 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO31841.1 - 0.02 15.0 9.2 2.2 8.6 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO31841.1 - 0.085 12.6 0.8 0.31 10.7 0.0 2.4 3 0 0 3 3 3 0 TPR repeat TPR_7 PF13176.6 KOO31841.1 - 0.25 11.5 1.7 24 5.3 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 KOO31842.1 - 2e-07 30.1 0.8 3.6e-07 29.3 0.8 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO31842.1 - 3.7e-07 29.6 0.2 7.8e-07 28.5 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO31842.1 - 1.5e-05 25.4 0.3 2.2e-05 24.8 0.4 1.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO31842.1 - 0.0034 17.2 0.1 0.0065 16.3 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO31842.1 - 0.025 14.0 1.1 0.084 12.4 1.0 2.0 2 1 1 3 3 3 0 EF hand EF-hand_6 PF13405.6 KOO31843.1 - 6.8e-05 22.5 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO31843.1 - 8.1e-05 21.9 0.0 0.00016 21.0 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO31843.1 - 0.00017 21.9 0.2 0.062 13.8 0.1 1.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO31843.1 - 0.0073 16.1 0.1 0.11 12.3 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO31843.1 - 0.043 13.3 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 EF hand Sel1 PF08238.12 KOO31844.1 - 7.7e-29 99.5 8.7 4.4e-10 39.9 0.3 4.0 4 0 0 4 4 4 3 Sel1 repeat TPR_6 PF13174.6 KOO31844.1 - 0.0026 18.3 5.4 2 9.2 0.1 4.1 3 1 0 3 3 3 2 Tetratricopeptide repeat DUF3580 PF12117.8 KOO31844.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3580) zf-RING_UBOX PF13445.6 KOO31845.1 - 3.2e-07 30.2 1.2 7.8e-07 29.0 1.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KOO31845.1 - 4.6e-07 29.9 0.3 1.1e-06 28.6 0.3 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KOO31845.1 - 1.9e-05 24.5 1.1 3.8e-05 23.5 1.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO31845.1 - 0.0002 21.1 1.8 0.00055 19.7 1.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO31845.1 - 0.05 13.6 2.7 0.1 12.6 2.7 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 KOO31845.1 - 0.097 13.0 3.0 0.25 11.7 3.0 1.8 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_3 PF13920.6 KOO31845.1 - 0.14 12.0 4.2 0.44 10.5 4.2 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) 2OG-FeII_Oxy_3 PF13640.6 KOO31846.1 - 2.8e-07 31.3 0.0 1.5e-06 29.0 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3638 PF12340.8 KOO31848.1 - 1.6e-32 112.7 0.5 3.3e-32 111.6 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO31848.1 - 5e-15 54.6 0.2 1.5e-14 53.1 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) AAA PF00004.29 KOO31848.1 - 0.047 14.1 0.4 3.9 7.9 0.0 3.6 3 1 1 4 4 4 0 ATPase family associated with various cellular activities (AAA) Nup188 PF10487.9 KOO31848.1 - 0.085 10.8 0.0 0.12 10.3 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 Amino_oxidase PF01593.24 KOO31849.1 - 4.7e-31 108.6 0.0 9.8e-31 107.5 0.0 1.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase PHD PF00628.29 KOO31849.1 - 1.6e-05 24.7 11.9 3.3e-05 23.7 11.9 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KOO31849.1 - 0.3 10.7 6.3 0.63 9.6 6.3 1.5 1 0 0 1 1 1 0 PHD-finger PHD_3 PF13922.6 KOO31849.1 - 0.75 10.2 4.7 1.2 9.5 4.7 1.4 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx LRR_6 PF13516.6 KOO31850.1 - 2.9e-33 111.1 15.1 9.9e-05 22.1 0.0 7.3 7 0 0 7 7 7 6 Leucine Rich repeat LRR_4 PF12799.7 KOO31850.1 - 0.00016 22.0 0.7 0.48 10.9 0.1 4.3 3 2 1 5 5 5 1 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.12 KOO31850.1 - 0.16 12.2 1.2 3.8 7.8 0.2 3.1 1 1 2 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding CRS1_YhbY PF01985.21 KOO31850.1 - 0.26 11.5 3.9 1.4 9.1 1.3 2.7 2 1 0 2 2 2 0 CRS1 / YhbY (CRM) domain CbiG_N PF11760.8 KOO31850.1 - 0.74 9.9 12.1 20 5.3 0.2 4.3 4 1 1 5 5 5 0 Cobalamin synthesis G N-terminal zf-C2H2 PF00096.26 KOO31851.1 - 0.19 12.2 0.3 0.43 11.1 0.3 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type Pkinase PF00069.25 KOO31852.1 - 7.8e-22 77.9 0.0 1.1e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Choline_kinase PF01633.20 KOO31852.1 - 0.025 14.1 0.0 0.036 13.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase CENP-B_dimeris PF09026.10 KOO31852.1 - 0.06 13.7 1.5 0.095 13.1 1.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Kdo PF06293.14 KOO31852.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_20 PF00728.22 KOO31853.1 - 1.2e-44 153.2 0.0 7.8e-42 143.9 0.0 3.5 2 1 0 2 2 2 1 Glycosyl hydrolase family 20, catalytic domain Ricin_B_lectin PF00652.22 KOO31853.1 - 3.3e-09 37.1 0.2 3.6e-05 24.0 0.1 2.3 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain FKBP_C PF00254.28 KOO31855.1 - 6.4e-29 100.1 0.0 1.1e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Rubis-subs-bind PF09273.11 KOO31855.1 - 0.0052 17.5 2.3 0.91 10.2 0.1 2.8 2 1 1 3 3 3 2 Rubisco LSMT substrate-binding WWE PF02825.20 KOO31857.1 - 2.8e-06 27.8 0.0 5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 WWE domain FCH PF00611.23 KOO31859.1 - 2.5e-05 24.5 2.3 8.4e-05 22.8 2.3 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Dyp_perox PF04261.12 KOO31859.1 - 0.029 13.4 0.2 0.042 12.8 0.2 1.2 1 0 0 1 1 1 0 Dyp-type peroxidase family RCC1_2 PF13540.6 KOO31860.1 - 7.7e-25 86.1 47.8 8.6e-05 22.2 3.6 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 KOO31860.1 - 8.1e-20 71.2 33.2 0.00036 21.1 0.2 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat EF-hand_1 PF00036.32 KOO31860.1 - 3.7e-09 35.5 2.2 0.00067 19.0 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO31860.1 - 5.1e-07 30.0 0.3 1.1e-06 29.0 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO31860.1 - 8.5e-07 28.4 0.3 0.00041 20.0 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO31860.1 - 3.9e-05 23.4 5.3 7.8e-05 22.4 0.5 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO31860.1 - 0.03 13.8 0.1 0.03 13.8 0.1 2.6 3 0 0 3 3 3 0 EF hand DUF5580 PF17743.1 KOO31860.1 - 0.17 10.4 0.0 0.26 9.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) HECT PF00632.25 KOO31862.1 - 3.8e-29 102.2 0.0 4.7e-28 98.6 0.0 2.5 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) PUB PF09409.10 KOO31862.1 - 3.7e-11 42.8 0.0 9.8e-11 41.4 0.0 1.6 2 0 0 2 2 2 1 PUB domain Big_1 PF02369.16 KOO31863.1 - 0.00069 19.6 0.2 1.2 9.2 0.0 5.3 7 0 0 7 7 7 1 Bacterial Ig-like domain (group 1) Mod_r PF07200.13 KOO31863.1 - 0.46 10.6 7.9 0.86 9.7 7.9 1.4 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Spc7 PF08317.11 KOO31863.1 - 1.7 7.5 10.8 3 6.6 10.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF724 PF05266.14 KOO31863.1 - 3 7.6 6.9 5 6.9 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Atg14 PF10186.9 KOO31863.1 - 3.4 6.7 5.3 28 3.7 6.9 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 LemA PF04011.12 KOO31863.1 - 4.5 7.1 8.3 1.4 8.8 4.6 1.9 2 0 0 2 2 2 0 LemA family DUF4407 PF14362.6 KOO31863.1 - 9.5 5.5 12.7 24 4.1 12.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) WD40 PF00400.32 KOO31865.1 - 1.6e-16 60.4 16.4 0.00024 21.8 0.2 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO31865.1 - 0.0036 17.6 0.1 4.9 7.5 0.0 3.6 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KOO31865.1 - 1.4 9.5 5.7 70 4.1 0.0 4.5 5 0 0 5 5 5 0 PQQ-like domain DUF1501 PF07394.12 KOO31866.1 - 1.7e-39 136.0 0.1 3.4e-39 135.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) DUF1800 PF08811.11 KOO31866.1 - 4.8e-22 78.6 0.0 8.5e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1800) NAD_binding_10 PF13460.6 KOO31868.1 - 1.7e-16 60.7 0.7 9.9e-16 58.2 0.7 2.1 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOO31868.1 - 3.5e-05 23.4 0.0 0.055 12.9 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NmrA PF05368.13 KOO31868.1 - 0.00013 21.6 0.1 0.00032 20.3 0.1 1.7 2 0 0 2 2 2 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 KOO31868.1 - 0.013 15.8 0.0 0.032 14.5 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 KOO31868.1 - 0.073 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Ldh_1_N PF00056.23 KOO31868.1 - 0.074 13.1 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 KOO31868.1 - 0.08 13.4 0.2 0.16 12.4 0.0 1.7 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Pkinase PF00069.25 KOO31869.1 - 1e-51 175.8 0.0 1.3e-51 175.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO31869.1 - 1.5e-19 70.3 0.0 2e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Plectin PF00681.20 KOO31869.1 - 0.014 15.3 0.0 0.04 13.8 0.0 1.8 1 0 0 1 1 1 0 Plectin repeat DUF5579 PF17742.1 KOO31869.1 - 0.033 13.7 0.1 0.057 13.0 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5579) CM_1 PF07736.11 KOO31873.1 - 0.13 12.7 0.0 0.14 12.6 0.0 1.1 1 0 0 1 1 1 0 Chorismate mutase type I DUF3494 PF11999.8 KOO31874.1 - 0.0037 16.9 0.1 0.0063 16.2 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3494) EF-hand_1 PF00036.32 KOO31875.1 - 6e-12 44.2 1.4 2.8e-05 23.4 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO31875.1 - 1.5e-08 33.8 0.3 7.8e-05 22.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO31875.1 - 3.8e-08 33.7 0.2 6.2e-08 33.0 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO31875.1 - 5.5e-07 29.3 2.6 5e-05 23.1 0.5 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO31875.1 - 5.7e-05 22.4 0.6 0.0031 16.9 0.1 2.3 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.9 KOO31875.1 - 0.046 14.0 0.0 0.083 13.2 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 KOO31875.1 - 0.052 12.1 0.0 0.08 11.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EF-hand_4 PF12763.7 KOO31875.1 - 0.14 12.1 0.1 0.29 11.1 0.1 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand ketoacyl-synt PF00109.26 KOO31876.1 - 2.8e-42 145.0 5.7 5.1e-42 144.2 5.7 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOO31876.1 - 1.5e-27 95.9 2.5 3.4e-27 94.8 2.5 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 KOO31876.1 - 7.6e-07 29.4 0.0 1.6e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site PDZ_6 PF17820.1 KOO31878.1 - 0.00016 21.4 0.2 0.00032 20.5 0.2 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO31878.1 - 0.0045 17.3 0.1 0.0076 16.6 0.1 1.3 1 0 0 1 1 1 1 PDZ domain EF-hand_1 PF00036.32 KOO31879.1 - 0.0017 17.8 0.0 0.0034 16.8 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO31879.1 - 0.0046 16.8 0.0 0.0095 15.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO31879.1 - 0.0089 16.5 0.0 0.012 16.0 0.0 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO31879.1 - 0.018 14.9 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 KOO31879.1 - 0.04 13.4 0.0 0.084 12.4 0.0 1.5 1 0 0 1 1 1 0 EF hand RTX PF02382.15 KOO31879.1 - 0.29 10.8 1.6 0.45 10.1 1.6 1.3 1 0 0 1 1 1 0 N-terminal domain in RTX protein Bacteriocin_IIc PF10439.9 KOO31879.1 - 0.77 9.9 6.5 1.2 9.3 6.5 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_YMGG PF13441.6 KOO31879.1 - 5 6.9 12.7 8.4 6.2 12.7 1.4 1 1 0 1 1 1 0 YMGG-like Gly-zipper Xpo1 PF08389.12 KOO31880.1 - 0.0045 17.1 0.2 0.097 12.7 0.0 2.9 3 0 0 3 3 3 1 Exportin 1-like protein RNase_E_G PF10150.9 KOO31880.1 - 0.24 10.8 4.0 0.38 10.1 4.0 1.3 1 0 0 1 1 1 0 Ribonuclease E/G family TMF_TATA_bd PF12325.8 KOO31880.1 - 3.6 7.8 9.0 8.4 6.7 9.0 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Guanylate_cyc PF00211.20 KOO31881.1 - 1.1e-06 28.4 0.0 1.8e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Agenet PF05641.12 KOO31881.1 - 0.17 12.4 0.4 0.4 11.2 0.4 1.6 1 0 0 1 1 1 0 Agenet domain Peptidase_M24 PF00557.24 KOO31882.1 - 1.1e-49 169.0 0.1 1.7e-49 168.4 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 SnoaL_2 PF12680.7 KOO31882.1 - 2.7e-06 27.9 0.1 1.6e-05 25.5 0.0 2.3 2 0 0 2 2 2 1 SnoaL-like domain DUF4829 PF16111.5 KOO31882.1 - 0.1 13.4 0.0 0.19 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4829) RVT_1 PF00078.27 KOO31883.1 - 0.14 11.6 0.0 0.34 10.4 0.0 1.5 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) HD_4 PF13328.6 KOO31885.1 - 1e-35 122.8 0.3 1.9e-35 121.9 0.3 1.5 1 0 0 1 1 1 1 HD domain RelA_SpoT PF04607.17 KOO31885.1 - 8.5e-29 100.2 0.0 1.2e-27 96.5 0.0 2.7 3 1 0 3 3 3 1 Region found in RelA / SpoT proteins ACT_4 PF13291.6 KOO31885.1 - 4.3e-17 62.5 0.2 7.5e-17 61.7 0.2 1.4 1 0 0 1 1 1 1 ACT domain HD PF01966.22 KOO31885.1 - 8.3e-05 22.8 0.0 0.00018 21.7 0.0 1.5 1 0 0 1 1 1 1 HD domain TGS PF02824.21 KOO31885.1 - 0.0018 18.3 0.0 0.0052 16.8 0.0 1.9 1 0 0 1 1 1 1 TGS domain ACT PF01842.25 KOO31885.1 - 0.0029 17.3 0.1 0.0061 16.3 0.1 1.6 1 0 0 1 1 1 1 ACT domain DNA_pol3_gamma3 PF12169.8 KOO31885.1 - 0.086 12.7 1.7 0.11 12.4 0.1 1.9 2 0 0 2 2 2 0 DNA polymerase III subunits gamma and tau domain III CN_hydrolase PF00795.22 KOO31887.1 - 1.2e-25 90.4 0.0 1.5e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase FAD_binding_7 PF03441.14 KOO31888.1 - 2.4e-40 138.2 0.5 3.2e-40 137.8 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase Glyco_transf_90 PF05686.12 KOO31890.1 - 8e-14 51.3 0.0 2.3e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 KOO31890.1 - 0.019 15.4 0.0 0.043 14.2 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 ASCH PF04266.14 KOO31891.1 - 0.04 14.5 0.0 0.09 13.4 0.0 1.6 1 0 0 1 1 1 0 ASCH domain DUF4614 PF15391.6 KOO31892.1 - 0.08 12.9 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) RhoGAP PF00620.27 KOO31893.1 - 2.5e-14 53.3 0.0 6.5e-14 52.0 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain PDZ PF00595.24 KOO31893.1 - 0.0016 18.7 0.0 0.0026 18.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Hemerythrin PF01814.23 KOO31895.1 - 0.0021 18.6 5.2 2 9.0 0.0 3.1 3 0 0 3 3 3 2 Hemerythrin HHE cation binding domain NUDIX PF00293.28 KOO31896.1 - 3.1e-05 24.0 0.0 4.5e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Bestrophin PF01062.21 KOO31897.1 - 1.6e-21 77.0 0.0 2e-21 76.6 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel SAM_1 PF00536.30 KOO31898.1 - 2.7e-10 40.5 0.0 8.3e-05 22.9 0.0 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO31898.1 - 2.2e-07 30.9 0.0 0.0002 21.4 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) HHH_2 PF12826.7 KOO31898.1 - 0.17 12.0 0.0 2 8.6 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif GFA PF04828.14 KOO31899.1 - 1.2e-10 41.6 0.5 1.2e-10 41.6 0.5 2.0 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme S4_2 PF13275.6 KOO31900.1 - 0.014 15.2 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 S4 domain DUF4116 PF13475.6 KOO31905.1 - 1.8e-54 181.2 0.0 1.2e-14 53.7 0.0 5.2 2 2 2 5 5 5 4 Domain of unknown function (DUF4116) EF-hand_1 PF00036.32 KOO31905.1 - 3.1e-16 57.6 0.5 5.5e-07 28.7 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO31905.1 - 5.8e-12 45.9 0.0 1.2e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO31905.1 - 8.4e-12 44.0 0.0 4.5e-06 26.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO31905.1 - 1.7e-11 43.7 0.9 1.1e-10 41.2 0.2 2.2 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO31905.1 - 3.1e-09 35.9 2.9 0.00013 21.3 0.0 3.4 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 KOO31905.1 - 6.2e-05 23.3 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain Rsbr_N PF08678.10 KOO31905.1 - 0.00026 21.1 0.0 6.9 6.8 0.0 4.0 1 1 4 5 5 5 2 Rsbr N terminal EF-hand_4 PF12763.7 KOO31905.1 - 0.0079 16.1 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand S-l_SbsC_C PF18316.1 KOO31905.1 - 0.016 15.7 9.5 7.8 7.1 0.1 5.0 1 1 1 4 4 4 0 S-layer protein SbsC C-terminal domain Mersacidin PF16934.5 KOO31905.1 - 0.023 14.4 8.2 0.22 11.3 0.1 4.1 4 0 0 4 4 4 0 Two-component Enterococcus faecalis cytolysin (EFC) PRA-CH PF01502.18 KOO31905.1 - 0.038 13.8 0.5 1.1e+02 2.8 0.0 4.5 1 1 3 5 5 5 0 Phosphoribosyl-AMP cyclohydrolase DUF1667 PF07892.11 KOO31905.1 - 0.11 12.6 0.1 93 3.2 0.0 3.7 1 1 2 4 4 4 0 Protein of unknown function (DUF1667) CbiG_C PF01890.16 KOO31905.1 - 0.14 12.7 13.2 3.9 8.1 0.1 4.9 1 1 3 4 4 4 0 Cobalamin synthesis G C-terminus SPARC_Ca_bdg PF10591.9 KOO31905.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Fringe PF02434.16 KOO31908.1 - 1.6e-07 31.0 0.0 2.2e-05 24.0 0.0 2.2 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 KOO31908.1 - 0.00011 22.1 0.0 0.00019 21.3 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Mhr1 PF12829.7 KOO31908.1 - 0.16 12.1 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination MOZ_SAS PF01853.18 KOO31909.1 - 2.2e-75 252.3 0.0 3.2e-75 251.7 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KOO31909.1 - 7.1e-18 64.0 0.4 6e-17 61.0 0.0 2.3 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 KOO31909.1 - 1.1e-17 63.6 0.8 3.4e-17 62.1 0.8 1.9 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 KOO31909.1 - 0.0063 16.9 0.0 0.02 15.3 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO31909.1 - 0.016 15.4 0.0 0.039 14.2 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family TrpBP PF02081.15 KOO31909.1 - 0.19 11.6 0.3 0.42 10.5 0.3 1.6 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein Chromo PF00385.24 KOO31909.1 - 0.2 11.6 3.5 0.89 9.5 0.8 2.5 1 1 1 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain NESP55 PF06390.12 KOO31910.1 - 0.31 10.6 0.9 0.42 10.2 0.9 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Ion_trans PF00520.31 KOO31911.1 - 8.1e-18 64.5 1.2 1.1e-17 64.1 1.2 1.2 1 0 0 1 1 1 1 Ion transport protein GPHH PF16905.5 KOO31911.1 - 1.6e-07 31.0 0.0 3.1e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO31911.1 - 0.0025 16.6 1.2 0.0033 16.2 1.2 1.2 1 0 0 1 1 1 1 Polycystin cation channel PARP PF00644.20 KOO31912.1 - 4.8e-52 176.4 0.0 9e-29 100.5 0.0 3.7 4 0 0 4 4 4 3 Poly(ADP-ribose) polymerase catalytic domain AAA_12 PF13087.6 KOO31912.1 - 3.1e-29 102.0 0.0 4.2e-28 98.3 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO31912.1 - 3e-21 76.4 1.2 8.3e-20 71.7 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOO31912.1 - 1.1e-08 35.5 0.0 0.00011 22.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 KOO31912.1 - 8.7e-08 32.1 0.1 0.00013 21.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain zf-CCCH PF00642.24 KOO31912.1 - 8.7e-06 25.5 1.9 1.8e-05 24.5 1.9 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KOO31912.1 - 0.00083 19.1 4.6 0.002 17.9 4.6 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger Viral_helicase1 PF01443.18 KOO31912.1 - 0.0023 17.7 0.0 4.5 6.9 0.0 3.4 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KOO31912.1 - 0.021 15.1 0.0 0.086 13.1 0.0 2.1 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KOO31912.1 - 0.06 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 KOO31912.1 - 0.17 11.3 0.0 0.38 10.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Tox-ART-HYD1 PF15633.6 KOO31912.1 - 0.2 12.3 0.0 2.5 8.8 0.0 2.7 3 0 0 3 3 3 0 HYD1 signature containing ADP-ribosyltransferase FUSC-like PF12805.7 KOO31912.1 - 0.36 9.9 1.9 0.92 8.5 1.9 1.7 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS AAA_16 PF13191.6 KOO31912.1 - 1.5 9.2 9.4 0.23 11.9 1.2 3.8 3 1 0 3 3 3 0 AAA ATPase domain zf-CCCH_2 PF14608.6 KOO31912.1 - 1.5 9.4 4.0 3.4 8.3 4.0 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger PARP PF00644.20 KOO31913.1 - 6.6e-37 127.0 0.0 1.5e-23 83.4 0.0 2.4 2 1 1 3 3 3 2 Poly(ADP-ribose) polymerase catalytic domain Ras PF00071.22 KOO31914.1 - 1.3e-48 164.6 0.0 1.5e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO31914.1 - 2.9e-28 98.5 0.0 4.4e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO31914.1 - 2.9e-16 59.4 0.0 3.4e-16 59.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KOO31914.1 - 0.00023 21.1 0.1 0.29 11.0 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 KOO31914.1 - 0.00055 19.4 0.0 0.00076 18.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 KOO31914.1 - 0.0011 19.2 0.3 0.13 12.5 0.2 2.5 1 1 1 2 2 2 1 AAA domain MeaB PF03308.16 KOO31914.1 - 0.0012 17.9 0.5 0.07 12.1 0.2 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 KOO31914.1 - 0.0037 17.4 0.0 0.0059 16.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO31914.1 - 0.0061 17.0 0.1 0.63 10.4 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA PF00004.29 KOO31914.1 - 0.022 15.2 0.1 0.14 12.6 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO31914.1 - 0.033 14.2 0.1 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 KOO31914.1 - 0.077 12.7 0.0 0.094 12.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain Ribosomal_S3_C PF00189.20 KOO31914.1 - 0.091 13.3 0.0 0.15 12.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S3, C-terminal domain DUF2183 PF09949.9 KOO31914.1 - 0.18 12.2 0.0 1.1 9.6 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) ATPase PF06745.13 KOO31914.1 - 0.19 11.0 0.1 0.34 10.2 0.1 1.3 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 KOO31914.1 - 0.23 11.0 0.0 0.39 10.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SH3_2 PF07653.17 KOO31915.1 - 7.1e-11 41.6 0.0 1.4e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOO31915.1 - 8.4e-09 35.2 0.0 1.9e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KOO31915.1 - 1.4e-08 34.2 0.2 2.9e-08 33.2 0.2 1.6 1 0 0 1 1 1 1 SH3 domain WW PF00397.26 KOO31916.1 - 1.7e-19 69.6 0.1 1.4e-08 34.7 0.0 2.5 2 0 0 2 2 2 2 WW domain NUC173 PF08161.12 KOO31917.1 - 2.2e-37 128.7 0.1 5.9e-33 114.3 0.0 2.5 2 0 0 2 2 2 2 NUC173 domain Mg_trans_NIPA PF05653.14 KOO31918.1 - 3.9e-05 22.9 3.3 0.0017 17.5 0.2 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 KOO31918.1 - 0.047 13.9 1.5 0.047 13.9 1.5 2.9 3 1 0 3 3 3 0 EamA-like transporter family MORN PF02493.20 KOO31919.1 - 5.5e-31 104.6 22.6 7.5e-08 31.8 1.9 6.3 6 0 0 6 6 6 5 MORN repeat DUF3048_C PF17479.2 KOO31919.1 - 0.098 13.0 3.0 9.4 6.7 0.1 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3048) C-terminal domain ART PF01129.18 KOO31920.1 - 1.1e-17 64.1 0.0 1.6e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Ank_5 PF13857.6 KOO31920.1 - 7e-09 35.8 0.2 2.6e-08 33.9 0.0 2.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO31920.1 - 1e-05 26.0 0.1 3.7e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) ADPrib_exo_Tox PF03496.14 KOO31920.1 - 6.4e-05 22.4 0.0 0.00015 21.2 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Ank_3 PF13606.6 KOO31920.1 - 0.0001 22.4 0.0 0.2 12.3 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KOO31920.1 - 0.0014 19.1 0.0 0.0029 18.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO31920.1 - 0.0027 18.1 0.0 0.065 13.7 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat DNase_II PF03265.15 KOO31921.1 - 2.8e-56 191.2 0.1 3.6e-56 190.8 0.1 1.1 1 0 0 1 1 1 1 Deoxyribonuclease II AAA_6 PF12774.7 KOO31922.1 - 4.8e-159 528.6 0.0 1.1e-157 524.1 0.0 2.8 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO31922.1 - 9.1e-124 413.6 0.1 9.1e-124 413.6 0.1 2.4 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 KOO31922.1 - 1.7e-67 226.5 0.5 9.8e-64 214.2 0.0 3.4 3 0 0 3 3 3 1 P-loop containing dynein motor region Dynein_AAA_lid PF17852.1 KOO31922.1 - 9e-26 90.5 0.0 3.1e-25 88.7 0.0 2.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO31922.1 - 6.6e-19 68.3 0.0 0.00016 21.7 0.0 4.6 3 1 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 KOO31922.1 - 3e-16 59.4 0.0 8.9e-16 57.9 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 KOO31922.1 - 1.8e-06 28.3 0.1 0.032 14.5 0.0 4.2 4 0 0 4 4 3 1 AAA domain RNA_helicase PF00910.22 KOO31922.1 - 2e-06 28.2 0.2 0.069 13.5 0.0 4.2 4 0 0 4 4 4 2 RNA helicase AAA_16 PF13191.6 KOO31922.1 - 2.4e-06 28.0 0.3 0.046 14.1 0.0 4.0 4 0 0 4 4 3 2 AAA ATPase domain AAA PF00004.29 KOO31922.1 - 1.1e-05 25.8 0.5 0.49 10.8 0.0 3.7 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOO31922.1 - 0.00026 21.0 5.2 0.036 14.0 0.0 4.1 4 0 0 4 4 4 1 NACHT domain AAA_30 PF13604.6 KOO31922.1 - 0.00031 20.5 0.1 0.66 9.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 KOO31922.1 - 0.00043 20.3 3.2 0.04 13.9 0.1 3.5 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KOO31922.1 - 0.0086 15.8 0.1 0.09 12.5 0.0 2.7 3 0 0 3 3 3 1 Sigma-54 interaction domain MnmE_helical PF12631.7 KOO31922.1 - 0.011 15.9 0.0 0.099 12.8 0.0 2.6 3 1 0 3 3 2 0 MnmE helical domain Mg_chelatase PF01078.21 KOO31922.1 - 0.028 13.8 2.9 0.47 9.8 0.0 3.1 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 KOO31922.1 - 0.031 13.3 1.5 0.92 8.5 0.0 2.9 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_19 PF13245.6 KOO31922.1 - 0.04 14.3 0.1 16 5.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 KOO31922.1 - 0.041 13.3 0.0 0.35 10.2 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein DUF853 PF05872.12 KOO31922.1 - 0.055 12.1 3.0 1.9 7.0 0.1 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) DUF815 PF05673.13 KOO31922.1 - 0.058 12.5 0.0 0.16 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 KOO31922.1 - 0.061 13.9 0.0 0.83 10.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain Self-incomp_S1 PF05938.11 KOO31922.1 - 0.07 13.7 0.2 0.18 12.4 0.2 1.6 1 0 0 1 1 1 0 Plant self-incompatibility protein S1 IstB_IS21 PF01695.17 KOO31922.1 - 0.13 11.9 0.1 2 8.1 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein ABC_tran PF00005.27 KOO31922.1 - 0.16 12.5 0.2 1.2 9.6 0.0 2.6 3 0 0 3 3 1 0 ABC transporter AAA_25 PF13481.6 KOO31922.1 - 0.17 11.5 1.0 10 5.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 KOO31922.1 - 0.22 11.7 4.2 4.9 7.3 0.1 3.6 4 0 0 4 4 3 0 AAA domain KinB_sensor PF16767.5 KOO31922.1 - 0.61 10.6 7.0 0.52 10.8 0.2 3.5 3 0 0 3 3 3 0 Sensor domain of alginate biosynthesis sensor protein KinB DUF5304 PF17230.2 KOO31922.1 - 1.4 9.2 3.7 0.74 10.1 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5304) OGFr_N PF04664.13 KOO31923.1 - 9.7e-52 175.5 0.0 1.2e-51 175.3 0.0 1.1 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Inhibitor_I9 PF05922.16 KOO31923.1 - 0.14 12.9 0.0 0.26 12.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I9 RRM_1 PF00076.22 KOO31924.1 - 2e-20 72.4 0.0 3.1e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ACC_epsilon PF13822.6 KOO31924.1 - 0.05 14.3 9.4 0.099 13.3 1.5 2.8 1 1 1 2 2 2 0 Acyl-CoA carboxylase epsilon subunit Choline_transpo PF04515.12 KOO31925.1 - 2.9e-58 197.6 32.8 2.9e-58 197.6 32.8 2.9 3 0 0 3 3 3 2 Plasma-membrane choline transporter Raftlin PF15250.6 KOO31926.1 - 0.099 11.4 6.7 0.15 10.8 6.7 1.2 1 0 0 1 1 1 0 Raftlin Epimerase PF01370.21 KOO31927.1 - 7e-18 65.0 0.0 8e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOO31927.1 - 2.3e-06 26.9 0.9 2.8e-06 26.7 0.1 1.4 2 0 0 2 2 2 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 KOO31927.1 - 0.00012 21.6 0.5 0.0002 20.9 0.1 1.4 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 KOO31927.1 - 0.00032 19.9 1.3 0.0025 17.0 0.0 2.0 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein Epimerase PF01370.21 KOO31928.1 - 2.2e-23 83.0 0.0 2.9e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO31928.1 - 0.0004 19.9 0.0 0.0005 19.6 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Filamin PF00630.19 KOO31929.1 - 1.2e-12 48.6 0.0 4.5e-07 30.6 0.0 4.3 4 0 0 4 4 4 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO31929.1 - 0.0057 16.9 0.0 0.091 13.1 0.0 2.7 3 0 0 3 3 3 1 Invasin, domain 3 MerR-DNA-bind PF09278.11 KOO31930.1 - 8.5e-16 58.3 9.9 0.94 10.1 0.1 11.4 8 2 4 12 12 12 5 MerR, DNA binding N_methyl PF07963.12 KOO31930.1 - 2.7e-10 39.4 12.7 6 6.6 0.1 9.9 8 2 3 11 11 11 4 Prokaryotic N-terminal methylation motif HTH_20 PF12840.7 KOO31930.1 - 3.8e-05 23.7 2.2 0.86 9.7 0.6 5.1 2 2 2 4 4 4 2 Helix-turn-helix domain Ribosomal_L13e PF01294.18 KOO31930.1 - 5.5e-05 23.1 17.7 0.36 10.7 0.2 8.0 2 2 8 10 10 10 3 Ribosomal protein L13e DUF5568 PF17724.1 KOO31930.1 - 0.00045 20.1 1.4 0.03 14.2 0.2 3.3 1 1 1 2 2 2 1 Family of unknown function (DUF5568) HTH_27 PF13463.6 KOO31930.1 - 0.0016 18.9 0.3 4.5 7.8 0.0 4.9 3 2 2 5 5 5 1 Winged helix DNA-binding domain AdoMetDC_leader PF08132.11 KOO31930.1 - 0.0062 16.4 0.6 1.1 9.2 0.0 4.2 5 1 1 6 6 6 1 S-adenosyl-l-methionine decarboxylase leader peptide RraB PF06877.11 KOO31930.1 - 0.01 16.5 0.1 29 5.5 0.0 4.1 2 2 2 4 4 4 0 Regulator of ribonuclease activity B Pentapeptide_4 PF13599.6 KOO31930.1 - 0.019 15.1 0.0 0.45 10.7 0.0 2.9 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) RPAP1_C PF08620.10 KOO31930.1 - 0.037 14.1 13.7 37 4.5 0.1 9.1 7 3 1 8 8 8 0 RPAP1-like, C-terminal DUF2812 PF11193.8 KOO31930.1 - 0.066 13.4 7.9 11 6.3 0.0 6.2 4 2 3 7 7 7 0 Protein of unknown function (DUF2812) GFRP PF06399.13 KOO31930.1 - 0.13 12.2 0.1 20 5.1 0.0 4.2 3 2 2 6 6 6 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) LytR_C PF13399.6 KOO31930.1 - 1.3 10.1 5.7 54 4.9 0.1 5.0 2 2 2 4 4 4 0 LytR cell envelope-related transcriptional attenuator UQ_con PF00179.26 KOO31932.1 - 1.3e-20 73.5 0.0 3.2e-20 72.2 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Ufd2P_core PF10408.9 KOO31932.1 - 2.2e-07 29.9 0.0 2.9e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core UEV PF05743.13 KOO31932.1 - 0.0075 16.1 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 UEV domain CRAL_TRIO PF00650.20 KOO31933.1 - 2.2e-15 56.7 0.0 3.4e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Peptidase_S49 PF01343.18 KOO31934.1 - 1.4e-60 203.7 0.0 2.5e-38 131.4 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 SDH_sah PF01972.16 KOO31934.1 - 5.9e-05 22.2 0.1 0.00011 21.3 0.1 1.3 1 0 0 1 1 1 1 Serine dehydrogenase proteinase CLP_protease PF00574.23 KOO31934.1 - 0.0062 16.4 0.0 0.1 12.5 0.0 2.7 3 0 0 3 3 3 1 Clp protease OKR_DC_1_N PF03709.15 KOO31934.1 - 0.011 15.9 0.0 1 9.7 0.0 2.5 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain MRP-L28 PF09812.9 KOO31935.1 - 0.019 15.1 0.0 0.022 14.9 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 Ribosomal_L14 PF00238.19 KOO31936.1 - 1.3e-31 109.2 0.2 2.3e-31 108.4 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e ABC_tran_CTD PF16326.5 KOO31937.1 - 0.097 12.9 3.8 7.3 6.9 0.1 2.6 2 0 0 2 2 2 0 ABC transporter C-terminal domain PP2C PF00481.21 KOO31938.1 - 4.5e-28 98.6 0.0 5.9e-28 98.2 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO31938.1 - 1.7e-06 28.1 0.1 0.01 15.8 0.1 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) DNA_pol_B_palm PF14792.6 KOO31939.1 - 2.9e-21 75.8 0.0 1.3e-19 70.5 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 KOO31939.1 - 4.7e-20 71.5 0.0 1.1e-19 70.4 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.6 KOO31939.1 - 1.4e-17 63.8 2.5 1.4e-16 60.6 0.6 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 KOO31939.1 - 2.3e-09 37.0 0.1 7.9e-09 35.2 0.0 2.0 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda WWE PF02825.20 KOO31939.1 - 3.9e-05 24.1 0.0 8.8e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 WWE domain HHH_5 PF14520.6 KOO31939.1 - 0.00014 22.4 1.4 0.081 13.5 0.1 2.6 2 0 0 2 2 2 2 Helix-hairpin-helix domain HHH PF00633.23 KOO31939.1 - 0.0095 15.8 0.7 4.1 7.5 0.2 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif Cdd1 PF11731.8 KOO31939.1 - 0.056 13.7 0.1 1.8 8.9 0.0 2.8 2 1 1 3 3 3 0 Pathogenicity locus HHH_3 PF12836.7 KOO31939.1 - 0.06 13.6 0.3 1.1 9.6 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix motif IMS_HHH PF11798.8 KOO31939.1 - 0.18 12.2 1.1 13 6.3 0.1 2.6 2 0 0 2 2 2 0 IMS family HHH motif DUF4719 PF15843.5 KOO31939.1 - 1.5 8.9 6.1 4.3 7.4 6.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) EF-hand_6 PF13405.6 KOO31940.1 - 2.5e-46 151.6 7.0 1.2e-05 24.9 0.0 9.0 9 0 0 9 9 9 8 EF-hand domain EF-hand_1 PF00036.32 KOO31940.1 - 1.9e-44 145.9 11.4 4.7e-06 25.8 0.0 8.5 8 0 0 8 8 8 8 EF hand EF-hand_7 PF13499.6 KOO31940.1 - 1.5e-41 140.7 14.0 3.7e-10 40.1 0.0 4.9 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO31940.1 - 1.9e-31 106.2 18.2 8.6e-06 25.0 0.1 8.4 9 0 0 9 9 9 7 EF hand EF-hand_8 PF13833.6 KOO31940.1 - 1.7e-24 85.4 18.2 2.3e-05 24.2 0.0 7.9 4 4 4 8 8 8 7 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO31940.1 - 1.9e-09 37.8 0.2 0.33 11.3 0.0 4.7 4 1 0 5 5 5 3 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO31940.1 - 2.2e-05 24.5 1.0 18 5.2 0.0 5.3 4 1 1 5 5 5 0 Caleosin related protein EF-hand_11 PF08976.11 KOO31940.1 - 3.9e-05 24.5 0.0 4.3 8.3 0.0 4.7 4 1 1 5 5 5 1 EF-hand domain EF-hand_9 PF14658.6 KOO31940.1 - 0.00028 21.1 0.2 6.1 7.2 0.0 5.5 6 2 1 7 7 7 2 EF-hand domain EF-hand_10 PF14788.6 KOO31940.1 - 0.045 13.6 5.8 4.7 7.1 0.0 4.9 6 1 1 7 7 7 0 EF hand EF-hand_4 PF12763.7 KOO31940.1 - 0.16 11.9 5.0 19 5.3 0.1 4.7 3 2 2 5 5 5 0 Cytoskeletal-regulatory complex EF hand SNARE PF05739.19 KOO31941.1 - 0.00016 21.6 0.3 0.00044 20.2 0.3 1.8 1 0 0 1 1 1 1 SNARE domain DDE_Tnp_1_6 PF13751.6 KOO31941.1 - 0.024 14.9 1.6 0.076 13.3 1.6 1.8 1 0 0 1 1 1 0 Transposase DDE domain Baculo_PEP_C PF04513.12 KOO31941.1 - 0.06 13.4 3.0 0.24 11.4 0.4 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.13 KOO31941.1 - 0.78 8.9 11.5 0.21 10.8 0.5 2.1 2 0 0 2 2 2 0 TMPIT-like protein NPV_P10 PF05531.12 KOO31941.1 - 2.1 8.9 10.5 5.5 7.5 4.4 3.3 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 KOO31941.1 - 4.7 6.5 18.9 5.3 6.3 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Rhodanese PF00581.20 KOO31942.1 - 1.3e-22 80.4 0.0 3.9e-12 46.6 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain MFS_1 PF07690.16 KOO31943.1 - 0.0025 16.8 8.0 0.0028 16.6 8.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily YoqO PF14037.6 KOO31943.1 - 0.092 13.3 7.2 0.15 12.6 7.2 1.5 1 1 0 1 1 1 0 YoqO-like protein FUSC-like PF12805.7 KOO31943.1 - 1.5 7.8 4.3 2.1 7.3 4.3 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS Laminin_G_3 PF13385.6 KOO31944.1 - 6.6e-11 42.6 0.0 2.9e-09 37.2 0.0 2.0 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily DUF4348 PF14254.6 KOO31944.1 - 0.00062 19.2 0.0 0.63 9.4 0.0 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4348) Methyltransf_12 PF08242.12 KOO31946.1 - 2.3e-10 41.1 0.0 4.8e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO31946.1 - 6.5e-10 39.6 0.1 4.9e-09 36.8 0.1 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO31946.1 - 2.1e-09 37.4 0.0 4e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO31946.1 - 4.8e-05 23.9 0.1 0.00011 22.8 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO31946.1 - 0.0033 17.2 0.0 0.0077 16.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOO31946.1 - 0.25 10.8 0.0 0.68 9.4 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase tRNA_bind PF01588.20 KOO31947.1 - 5.9e-26 90.4 0.0 8.3e-26 89.9 0.0 1.2 1 0 0 1 1 1 1 Putative tRNA binding domain DUF846 PF05832.12 KOO31948.1 - 6e-47 159.2 11.8 7.6e-47 158.8 11.8 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) FA_desaturase PF00487.24 KOO31950.1 - 8.9e-23 81.4 21.4 1.2e-22 80.9 14.9 2.2 1 1 1 2 2 2 2 Fatty acid desaturase KRBA1 PF15287.6 KOO31951.1 - 0.099 12.4 0.5 0.099 12.4 0.5 2.4 2 0 0 2 2 2 0 KRBA1 family repeat EamA PF00892.20 KOO31952.1 - 1.1e-17 64.5 22.1 7.5e-12 45.6 9.6 2.3 2 0 0 2 2 2 2 EamA-like transporter family 2OG-FeII_Oxy_3 PF13640.6 KOO31953.1 - 8.9e-17 61.8 0.0 2.2e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KOO31953.1 - 4.5e-06 27.2 0.0 0.0016 19.0 0.0 2.4 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily Carbam_trans_C PF16861.5 KOO31954.1 - 2.5e-27 95.5 0.0 6.7e-25 87.6 0.0 2.4 1 1 1 2 2 2 2 Carbamoyltransferase C-terminus Carbam_trans_N PF02543.15 KOO31954.1 - 9e-26 91.3 0.1 2.2e-21 76.9 0.0 3.3 2 1 0 2 2 2 2 Carbamoyltransferase N-terminus ABC_tran PF00005.27 KOO31954.1 - 3.7e-07 30.7 0.0 8.7e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOO31954.1 - 0.0009 19.1 0.0 0.0015 18.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOO31954.1 - 0.032 14.0 0.2 0.076 12.8 0.2 1.6 1 1 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 KOO31954.1 - 0.055 14.0 0.1 0.055 14.0 0.1 1.7 2 0 0 2 2 1 0 AAA domain AAA PF00004.29 KOO31954.1 - 0.1 13.0 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 KOO31954.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein NACHT PF05729.12 KOO31954.1 - 0.13 12.2 0.0 0.81 9.6 0.0 2.2 2 0 0 2 2 2 0 NACHT domain DUF815 PF05673.13 KOO31954.1 - 0.16 11.1 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_15 PF13175.6 KOO31954.1 - 0.18 11.5 0.0 0.27 10.9 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_13 PF13166.6 KOO31954.1 - 0.19 10.4 0.0 0.34 9.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain SWIRM-assoc_3 PF16498.5 KOO31954.1 - 0.32 11.3 3.2 23 5.3 0.1 3.2 2 0 0 2 2 2 0 SWIRM-associated domain at the C-terminal AAA_16 PF13191.6 KOO31954.1 - 0.39 11.1 4.4 4.5 7.6 0.1 3.9 3 0 0 3 3 3 0 AAA ATPase domain Arm PF00514.23 KOO31955.1 - 1.7e-47 158.1 74.0 8.7e-09 35.1 0.0 19.9 22 0 0 22 22 22 12 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO31955.1 - 0.00049 20.1 0.0 38 4.4 0.0 5.5 5 1 2 7 7 7 2 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.6 KOO31955.1 - 0.037 14.4 0.1 0.037 14.4 0.1 11.2 4 2 8 12 12 12 0 HEAT repeats Adaptin_N PF01602.20 KOO31955.1 - 0.09 11.3 0.1 0.8 8.2 0.0 2.0 2 0 0 2 2 2 0 Adaptin N terminal region Arm PF00514.23 KOO31956.1 - 2e-101 329.3 107.9 1.6e-05 24.7 0.1 29.7 30 2 1 31 31 31 23 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO31956.1 - 2.2e-12 46.8 9.0 0.0038 17.2 0.3 8.9 9 1 1 10 10 10 2 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO31956.1 - 1.7e-10 40.8 8.0 2.6 7.4 0.0 8.9 8 3 2 11 11 11 4 Armadillo-like C2 PF00168.30 KOO31956.1 - 1.2e-09 38.3 0.0 1.5e-08 34.9 0.0 2.3 1 1 0 1 1 1 1 C2 domain Cnd1 PF12717.7 KOO31956.1 - 2.3e-07 31.0 0.0 0.32 11.0 0.0 6.9 5 3 2 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KOO31956.1 - 0.00021 20.0 3.4 0.086 11.4 0.0 5.5 4 2 2 6 6 6 2 Adaptin N terminal region HEAT PF02985.22 KOO31956.1 - 0.00033 20.7 44.8 0.052 13.8 0.1 14.4 15 0 0 15 15 15 2 HEAT repeat HEAT_2 PF13646.6 KOO31956.1 - 0.0006 20.2 1.7 0.0006 20.2 1.7 14.2 8 4 6 16 16 16 6 HEAT repeats V-ATPase_H_C PF11698.8 KOO31956.1 - 0.00081 19.5 0.0 14 5.8 0.0 5.0 4 1 0 4 4 4 1 V-ATPase subunit H RYDR_ITPR PF01365.21 KOO31956.1 - 0.00085 18.8 0.4 0.49 9.8 0.0 3.8 3 1 0 4 4 4 1 RIH domain HEAT_EZ PF13513.6 KOO31956.1 - 0.0034 17.9 1.8 0.0034 17.9 1.8 16.0 17 3 1 18 18 17 3 HEAT-like repeat BAF250_C PF12031.8 KOO31956.1 - 0.014 14.7 4.8 2.1 7.6 0.0 5.4 5 0 0 5 5 5 0 SWI/SNF-like complex subunit BAF250/Osa Nucleotid_trans PF03407.16 KOO31957.1 - 3e-26 92.7 0.0 5.1e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ArfGap PF01412.18 KOO31957.1 - 3.8e-22 78.6 0.0 3.5e-21 75.5 0.3 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 KOO31957.1 - 6.6e-06 26.0 0.0 1.7e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 KOO31957.1 - 2.7e-05 24.6 0.0 4.7e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_2 PF08458.10 KOO31957.1 - 0.17 12.2 0.0 0.38 11.1 0.0 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Cytochrom_C552 PF02335.15 KOO31957.1 - 0.21 10.5 0.1 0.47 9.3 0.1 1.5 1 0 0 1 1 1 0 Cytochrome c552 Ub-Mut7C PF14451.6 KOO31957.1 - 0.77 9.6 2.7 2.1 8.2 0.1 2.7 3 0 0 3 3 3 0 Mut7-C ubiquitin LRR_6 PF13516.6 KOO31958.1 - 5.4e-34 113.3 18.6 0.00018 21.3 0.4 7.9 8 0 0 8 8 8 7 Leucine Rich repeat LRR_4 PF12799.7 KOO31958.1 - 4.9e-07 30.0 5.4 2.1 8.9 0.0 6.3 3 2 5 8 8 8 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO31958.1 - 0.0051 17.2 0.0 1.7e+02 3.4 0.0 5.9 8 0 0 8 8 8 0 Leucine Rich Repeat HOASN PF14515.6 KOO31958.1 - 0.42 11.0 12.2 14 6.1 0.2 6.1 1 1 5 6 6 6 0 Haem-oxygenase-associated N-terminal helices CoatB PF10389.9 KOO31958.1 - 6.8 6.6 9.3 43 4.1 0.3 4.3 2 2 3 5 5 5 0 Bacteriophage coat protein B Cyclin_N PF00134.23 KOO31961.1 - 2.7e-19 69.2 0.5 3.8e-19 68.7 0.5 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOO31961.1 - 0.00016 21.7 0.3 0.0012 18.9 0.0 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain GLE1 PF07817.13 KOO31962.1 - 0.0088 15.3 1.9 0.014 14.6 1.9 1.2 1 0 0 1 1 1 1 GLE1-like protein FAM76 PF16046.5 KOO31962.1 - 0.028 13.8 2.8 0.044 13.2 2.8 1.5 1 0 0 1 1 1 0 FAM76 protein Lectin_N PF03954.14 KOO31962.1 - 0.58 9.9 4.9 36 4.1 2.5 3.3 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain Muted PF14942.6 KOO31962.1 - 1.2 9.4 8.7 0.44 10.9 5.4 1.9 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein KIAA1430 PF13879.6 KOO31965.1 - 3.1e-18 66.4 0.7 1.8e-17 63.9 0.3 2.0 2 0 0 2 2 2 1 KIAA1430 homologue DUF4315 PF14193.6 KOO31965.1 - 0.12 12.4 2.5 0.1 12.6 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) Chloroa_b-bind PF00504.21 KOO31966.1 - 7.1e-28 98.2 0.1 1e-27 97.6 0.1 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein CRAL_TRIO PF00650.20 KOO31967.1 - 4.8e-18 65.4 0.0 8.5e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Rad52_Rad22 PF04098.15 KOO31968.1 - 2e-06 27.8 0.0 3.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein RRM_1 PF00076.22 KOO31968.1 - 0.24 11.3 0.0 0.74 9.7 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PP2C PF00481.21 KOO31970.1 - 3e-44 151.6 0.0 3.7e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_5 PF13306.6 KOO31971.1 - 5.5e-151 495.2 0.0 1.8e-34 118.5 0.0 5.0 1 1 4 5 5 5 5 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO31971.1 - 7.5e-31 105.7 0.0 0.032 14.0 0.0 11.4 1 1 14 15 15 15 15 Leucine rich repeat Forkhead_N PF08430.12 KOO31971.1 - 0.63 10.6 48.4 1.8e+04 -31.4 48.4 6.0 1 1 0 1 1 1 0 Forkhead N-terminal region Pyridoxal_deC PF00282.19 KOO31972.1 - 2.6e-21 75.8 0.0 6.9e-21 74.4 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 KOO31972.1 - 2.2e-06 26.9 0.0 5.5e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KOO31972.1 - 2.5e-05 23.7 0.0 3.4e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DNA_photolyase PF00875.18 KOO31973.1 - 1.7e-10 41.1 0.6 4e-10 40.0 0.6 1.6 1 1 0 1 1 1 1 DNA photolyase SRP54 PF00448.22 KOO31973.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.1 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain INCENP_ARK-bind PF03941.15 KOO31973.1 - 0.19 11.7 1.1 0.47 10.4 1.1 1.6 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region Cas9_REC PF16592.5 KOO31974.1 - 0.072 11.8 0.0 0.097 11.4 0.0 1.1 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 ANAPC5 PF12862.7 KOO31976.1 - 0.0075 16.3 0.3 3.5 7.7 0.1 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 5 YjgF_endoribonc PF14588.6 KOO31978.1 - 5e-19 68.9 0.0 6.2e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 KOO31978.1 - 3.5e-10 39.9 0.0 5.9e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP Haem_degrading PF03928.14 KOO31978.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Haem-degrading Homeodomain PF00046.29 KOO31979.1 - 6.9e-12 45.0 0.1 1.7e-11 43.8 0.1 1.6 1 0 0 1 1 1 1 Homeodomain SRA1 PF07304.11 KOO31979.1 - 1.6e-07 31.2 0.4 1.2e-06 28.3 0.0 2.2 2 0 0 2 2 2 1 Steroid receptor RNA activator (SRA1) Homeobox_KN PF05920.11 KOO31979.1 - 0.0039 17.1 0.2 0.0067 16.3 0.2 1.4 1 0 0 1 1 1 1 Homeobox KN domain HMG_box PF00505.19 KOO31981.1 - 1.1e-27 96.2 13.9 1.1e-16 61.0 1.1 3.4 5 0 0 5 5 5 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO31981.1 - 4.4e-24 84.9 6.0 4.2e-14 52.9 1.3 2.6 2 0 0 2 2 2 2 HMG-box domain Ccdc124 PF06244.12 KOO31981.1 - 0.00094 19.7 1.0 0.00094 19.7 1.0 3.1 2 1 1 3 3 3 1 Coiled-coil domain-containing protein 124 /Oxs1 DUF5082 PF16888.5 KOO31981.1 - 0.029 14.7 4.1 0.083 13.2 4.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) RNR_N PF08343.10 KOO31981.1 - 0.046 13.7 0.5 0.11 12.6 0.5 1.5 1 0 0 1 1 1 0 Ribonucleotide reductase N-terminal CHDNT PF08073.12 KOO31981.1 - 0.062 13.3 0.0 4.8 7.2 0.0 2.5 2 0 0 2 2 2 0 CHDNT (NUC034) domain KRAB PF01352.27 KOO31981.1 - 0.14 11.8 0.0 3.1 7.5 0.0 2.3 2 0 0 2 2 2 0 KRAB box HMG_box_5 PF14887.6 KOO31981.1 - 2.3 8.3 9.2 1.5 8.9 0.4 2.8 3 0 0 3 3 3 0 HMG (high mobility group) box 5 Endonuc-FokI_C PF09254.11 KOO31982.1 - 0.045 13.0 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal RYDR_ITPR PF01365.21 KOO31984.1 - 8e-05 22.1 0.2 0.00017 21.0 0.2 1.5 1 0 0 1 1 1 1 RIH domain Radical_SAM PF04055.21 KOO31985.1 - 0.14 12.5 0.0 0.66 10.3 0.0 2.0 2 0 0 2 2 2 0 Radical SAM superfamily RYDR_ITPR PF01365.21 KOO31986.1 - 1.1e-21 77.2 0.9 1.6e-21 76.6 0.9 1.3 1 0 0 1 1 1 1 RIH domain Opiods_neuropep PF01160.18 KOO31986.1 - 0.025 14.7 0.5 0.09 12.9 0.5 2.0 1 0 0 1 1 1 0 Vertebrate endogenous opioids neuropeptide MIR PF02815.19 KOO31986.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 MIR domain KH_1 PF00013.29 KOO31987.1 - 1.4e-38 130.5 4.7 2.8e-15 55.9 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 KOO31987.1 - 8.9e-11 41.5 3.4 0.011 15.5 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 KOO31987.1 - 0.00019 21.2 9.4 0.11 12.3 0.1 3.5 2 1 1 3 3 3 3 KH domain KH_5 PF13184.6 KOO31987.1 - 0.0047 17.0 4.1 3.5 7.8 0.1 3.2 3 0 0 3 3 3 2 NusA-like KH domain RIH_assoc PF08454.11 KOO31988.1 - 8.5e-20 70.5 2.6 5.8e-19 67.8 0.5 3.0 3 0 0 3 3 3 1 RyR and IP3R Homology associated Ion_trans PF00520.31 KOO31988.1 - 1.9e-09 37.2 12.7 3e-09 36.5 12.7 1.3 1 0 0 1 1 1 1 Ion transport protein PRKG1_interact PF15898.5 KOO31988.1 - 0.17 12.8 6.4 0.072 14.0 3.6 1.8 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF3138 PF11336.8 KOO31988.1 - 0.29 9.7 1.5 0.4 9.2 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TSNAXIP1_N PF15739.5 KOO31988.1 - 0.49 10.8 3.0 1.8 8.9 3.0 2.0 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus CENP-F_leu_zip PF10473.9 KOO31988.1 - 0.72 9.9 9.0 0.4 10.7 5.9 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF948 PF06103.11 KOO31988.1 - 1.1 9.6 4.6 5.6 7.3 1.0 3.6 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF4282 PF14110.6 KOO31988.1 - 3.8 8.3 10.6 31 5.4 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) Glycolytic PF00274.19 KOO31989.1 - 5.5e-137 456.2 0.0 6.3e-137 456.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I LPD22 PF18834.1 KOO31989.1 - 0.11 12.7 0.4 0.49 10.6 0.0 2.3 3 0 0 3 3 3 0 Large polyvalent protein associated domain 22 NHL PF01436.21 KOO31990.1 - 7e-24 82.6 11.9 0.00014 21.7 0.2 6.6 6 1 0 6 6 6 5 NHL repeat SGL PF08450.12 KOO31990.1 - 8.5e-08 32.1 0.0 0.0039 16.8 0.0 3.0 2 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region PQQ_2 PF13360.6 KOO31990.1 - 0.00028 20.5 0.2 4.6 6.7 0.0 3.5 1 1 0 3 3 3 2 PQQ-like domain PQQ_3 PF13570.6 KOO31990.1 - 0.0035 17.8 8.9 0.22 12.1 0.2 4.6 4 1 1 5 5 5 2 PQQ-like domain DUF5128 PF17170.4 KOO31990.1 - 0.0062 15.7 0.0 3.9 6.5 0.0 3.0 2 1 1 3 3 3 1 6-bladed beta-propeller Str_synth PF03088.16 KOO31990.1 - 0.033 14.3 0.0 2.8 8.1 0.0 2.9 2 0 0 2 2 2 0 Strictosidine synthase PG_isomerase_N PF18353.1 KOO31990.1 - 0.034 14.5 0.0 8 6.9 0.0 2.3 1 1 1 2 2 2 0 Phosphoglucose isomerase N-terminal domain GlutR_N PF05201.15 KOO31991.1 - 4.6e-38 130.3 0.0 1e-37 129.1 0.0 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.20 KOO31991.1 - 1.3e-34 119.2 0.0 7.9e-34 116.7 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.20 KOO31991.1 - 1.6e-21 76.6 0.7 3.3e-21 75.5 0.7 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain F420_oxidored PF03807.17 KOO31991.1 - 0.00073 20.1 0.5 0.0045 17.5 0.0 2.7 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.15 KOO31991.1 - 0.0013 17.8 0.0 0.0036 16.3 0.0 1.7 2 0 0 2 2 2 1 Ornithine cyclodeaminase/mu-crystallin family NAD_binding_2 PF03446.15 KOO31991.1 - 0.0091 16.2 0.2 0.083 13.1 0.0 2.6 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 KOO31991.1 - 0.0092 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA GFO_IDH_MocA PF01408.22 KOO31991.1 - 0.011 16.6 0.0 2 9.2 0.0 3.3 3 0 0 3 3 3 0 Oxidoreductase family, NAD-binding Rossmann fold KR PF08659.10 KOO31991.1 - 0.017 15.1 1.8 0.099 12.5 0.0 2.5 2 0 0 2 2 2 0 KR domain ThiF PF00899.21 KOO31991.1 - 0.033 13.6 0.3 0.084 12.2 0.3 1.6 1 0 0 1 1 1 0 ThiF family Sacchrp_dh_NADP PF03435.18 KOO31991.1 - 0.05 13.9 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1133 PF06576.11 KOO31991.1 - 0.34 10.3 1.1 1.1 8.7 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1133) SHIPPO-rpt PF07004.12 KOO31993.1 - 1.3e-05 25.9 8.6 9.1 7.4 0.0 6.8 6 0 0 6 6 6 3 Sperm-tail PG-rich repeat Peptidase_M50 PF02163.22 KOO31993.1 - 0.038 13.3 0.0 8.5 5.6 0.0 2.1 2 0 0 2 2 2 0 Peptidase family M50 Myb_DNA-binding PF00249.31 KOO31994.1 - 6e-18 64.8 0.8 1.1e-11 44.7 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO31994.1 - 3.4e-11 43.2 0.4 3.2e-05 24.1 0.4 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO31994.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Myb DNA-binding like NDUF_B12 PF08122.12 KOO31995.1 - 5.5e-07 29.5 0.3 1.2e-06 28.4 0.3 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family DUF2777 PF10949.8 KOO31996.1 - 0.23 11.1 0.0 0.36 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2777) Tad PF13400.6 KOO31996.1 - 5.3 7.4 12.2 0.15 12.4 5.6 1.8 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like CytochromB561_N PF09786.9 KOO31997.1 - 1.6e-24 86.9 0.2 1.7e-23 83.5 0.2 2.5 1 1 0 1 1 1 1 Cytochrome B561, N terminal MFS_3 PF05977.13 KOO32000.1 - 4e-05 22.2 8.1 4e-05 22.2 8.1 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_1 PF07690.16 KOO32000.1 - 0.5 9.2 37.4 0.16 10.8 31.2 2.2 1 1 1 2 2 2 0 Major Facilitator Superfamily DUF21 PF01595.20 KOO32000.1 - 3.4 7.3 9.7 1.4 8.6 2.0 3.3 2 1 1 3 3 3 0 Cyclin M transmembrane N-terminal domain Homeodomain PF00046.29 KOO32001.1 - 3.4e-16 58.8 0.5 7.1e-16 57.8 0.5 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOO32001.1 - 6.8e-06 25.9 0.2 2.7e-05 24.0 0.1 2.1 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.5 KOO32001.1 - 0.0073 16.1 0.3 0.013 15.3 0.3 1.3 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Homez PF11569.8 KOO32001.1 - 0.21 11.1 1.6 0.3 10.6 0.1 1.9 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez HTH_28 PF13518.6 KOO32001.1 - 0.33 11.1 2.5 0.22 11.7 0.7 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain CH PF00307.31 KOO32002.1 - 3.7e-18 65.7 0.4 1.1e-10 41.6 0.1 2.9 2 1 1 3 3 3 2 Calponin homology (CH) domain YAcAr PF10686.9 KOO32002.1 - 3.4 7.7 6.6 0.33 10.9 0.3 2.5 2 0 0 2 2 2 0 YspA, cpYpsA-related SLOG family LRR_6 PF13516.6 KOO32003.1 - 2.5e-12 45.8 0.3 0.013 15.5 0.0 7.0 8 0 0 8 8 8 4 Leucine Rich repeat ART PF01129.18 KOO32003.1 - 0.00076 18.8 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_4 PF12799.7 KOO32003.1 - 0.03 14.7 5.0 10 6.7 0.0 4.2 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO32003.1 - 0.037 14.6 0.0 45 5.2 0.0 4.4 4 1 0 4 4 4 0 Leucine Rich Repeat GIT_CC PF16559.5 KOO32004.1 - 0.00018 21.3 8.7 0.028 14.3 1.7 4.0 3 0 0 3 3 3 2 GIT coiled-coil Rho guanine nucleotide exchange factor ATG16 PF08614.11 KOO32004.1 - 0.0013 19.0 11.2 0.0013 19.0 11.2 4.6 2 1 2 4 4 3 1 Autophagy protein 16 (ATG16) Rootletin PF15035.6 KOO32004.1 - 0.0033 17.5 3.6 0.0033 17.5 3.6 3.7 3 1 0 3 3 2 1 Ciliary rootlet component, centrosome cohesion MscS_porin PF12795.7 KOO32004.1 - 0.0037 16.9 12.4 0.0037 16.9 12.4 5.3 2 1 3 5 5 4 2 Mechanosensitive ion channel porin domain Spc7 PF08317.11 KOO32004.1 - 0.0042 16.0 1.6 0.0042 16.0 1.6 4.2 2 1 2 4 4 4 2 Spc7 kinetochore protein Vps52 PF04129.12 KOO32004.1 - 0.025 13.3 0.2 0.025 13.3 0.2 1.6 2 0 0 2 2 2 0 Vps52 / Sac2 family BLOC1_2 PF10046.9 KOO32004.1 - 0.077 13.3 22.7 0.036 14.4 2.0 5.5 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin_1 PF12718.7 KOO32004.1 - 0.27 11.4 60.1 0.12 12.5 0.9 5.6 2 1 2 5 5 5 0 Tropomyosin like DUF1664 PF07889.12 KOO32004.1 - 0.57 10.2 17.2 3 7.9 0.2 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 KOO32004.1 - 1.1 9.4 13.9 8 6.6 0.0 4.5 4 1 1 5 5 5 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.20 KOO32004.1 - 5.4 7.0 30.8 0.77 9.7 1.5 5.7 4 2 1 5 5 5 0 Prefoldin subunit EF-hand_6 PF13405.6 KOO32005.1 - 6e-11 41.4 5.7 9.7e-05 22.0 0.2 3.6 3 1 1 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 KOO32005.1 - 2e-10 39.4 11.5 6.9e-05 22.1 0.1 4.6 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.6 KOO32005.1 - 4.1e-10 40.0 4.9 0.00022 21.6 0.1 2.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO32005.1 - 4.1e-10 38.7 0.9 0.00026 20.3 0.1 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO32005.1 - 1.2e-09 37.9 8.6 0.00041 20.1 0.2 3.9 2 1 2 4 4 4 2 EF-hand domain pair DUF1456 PF07308.13 KOO32005.1 - 0.0058 16.9 3.3 0.016 15.5 0.3 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF1456) SurA_N_3 PF13624.6 KOO32005.1 - 0.033 14.0 0.7 0.092 12.5 0.6 1.9 1 1 0 1 1 1 0 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KOO32005.1 - 0.072 13.4 0.4 11 6.4 0.0 2.3 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3008 PF11450.8 KOO32005.1 - 0.21 11.8 5.2 8.1 6.7 0.6 2.9 3 0 0 3 3 3 0 Protein of unknwon function (DUF3008) His_Phos_1 PF00300.22 KOO32006.1 - 9.4e-13 48.3 0.0 1.6e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Tubulin PF00091.25 KOO32006.1 - 0.0016 18.6 0.4 0.0027 17.9 0.4 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Abhydro_lipase PF04083.16 KOO32006.1 - 0.15 11.7 0.0 0.33 10.5 0.0 1.6 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region HA2 PF04408.23 KOO32007.1 - 2.5e-16 59.9 0.2 8.5e-16 58.2 0.2 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KOO32007.1 - 1.3e-10 41.6 0.0 3e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 KOO32007.1 - 1.1e-08 35.3 0.0 2.3e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold TPR_12 PF13424.6 KOO32007.1 - 7e-08 32.7 4.2 6.5e-05 23.1 1.6 5.3 2 2 2 4 4 4 3 Tetratricopeptide repeat DEAD PF00270.29 KOO32007.1 - 3.7e-07 30.1 0.0 6.7e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase TPR_8 PF13181.6 KOO32007.1 - 5.1e-05 23.2 0.1 0.059 13.6 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO32007.1 - 0.0007 19.4 17.1 0.12 12.3 0.9 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat AAA_22 PF13401.6 KOO32007.1 - 0.0013 19.0 0.0 0.0036 17.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain zf-met PF12874.7 KOO32007.1 - 0.0061 16.9 0.2 0.014 15.8 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Peptidase_S26 PF10502.9 KOO32007.1 - 0.039 13.7 0.1 0.42 10.4 0.0 2.4 2 0 0 2 2 2 0 Signal peptidase, peptidase S26 TPR_1 PF00515.28 KOO32007.1 - 0.69 9.8 6.3 9.1 6.3 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO32007.1 - 1.1 9.6 20.0 0.07 13.3 0.3 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat MAGE_N PF12440.8 KOO32007.1 - 1.3 9.7 5.6 7.9 7.2 5.6 2.4 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal RVT_2 PF07727.14 KOO32009.1 - 5.6e-08 32.7 0.0 9e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ank_2 PF12796.7 KOO32011.1 - 4.7e-23 81.6 4.2 6.1e-12 46.0 0.1 3.2 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) LRR_8 PF13855.6 KOO32011.1 - 6e-17 61.2 3.5 1.2e-09 37.8 0.3 3.0 3 0 0 3 3 3 2 Leucine rich repeat Ank_4 PF13637.6 KOO32011.1 - 1.1e-15 57.8 3.5 3.7e-07 30.6 0.3 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO32011.1 - 1.2e-13 51.0 10.7 2.4e-06 27.7 1.0 5.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) LRR_4 PF12799.7 KOO32011.1 - 1.4e-10 41.3 2.0 0.0084 16.5 0.0 4.0 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) C2 PF00168.30 KOO32011.1 - 5e-10 39.6 0.0 8.3e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain Ank_3 PF13606.6 KOO32011.1 - 1.2e-09 37.6 6.8 0.49 11.1 0.1 5.9 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 KOO32011.1 - 1.3e-08 34.9 16.6 0.0053 17.2 0.3 5.4 4 1 1 5 5 5 3 Ankyrin repeat LRR_1 PF00560.33 KOO32011.1 - 0.0019 18.5 2.9 4.1 8.3 0.1 5.1 4 2 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 KOO32011.1 - 0.0071 16.3 4.1 3.7 7.8 0.0 4.9 5 0 0 5 5 5 1 Leucine Rich repeat Rdx PF10262.9 KOO32011.1 - 0.18 12.0 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 Rdx family KIAA1430 PF13879.6 KOO32014.1 - 6e-09 36.6 0.0 1.3e-08 35.5 0.0 1.5 1 0 0 1 1 1 1 KIAA1430 homologue CCDC-167 PF15188.6 KOO32014.1 - 0.11 12.9 0.2 0.25 11.7 0.2 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 CDC37_N PF03234.14 KOO32015.1 - 1.3 9.9 3.4 25 5.8 2.1 2.3 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding LRR_6 PF13516.6 KOO32017.1 - 3.1e-06 26.8 7.6 0.052 13.6 0.1 5.5 6 0 0 6 6 6 3 Leucine Rich repeat Kelch_1 PF01344.25 KOO32018.1 - 2.4e-82 270.3 0.1 3.9e-16 58.4 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KOO32018.1 - 4.2e-50 166.5 0.0 5.4e-12 45.5 0.0 6.6 4 1 2 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KOO32018.1 - 1.5e-36 123.0 0.0 1.4e-08 34.4 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KOO32018.1 - 1.1e-33 114.9 6.1 1.6e-07 31.4 0.1 6.6 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO32018.1 - 2.7e-27 94.5 0.0 5e-07 29.6 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain DUF1350 PF07082.11 KOO32018.1 - 2.9e-23 82.5 0.0 5.2e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1350) BACK PF07707.15 KOO32018.1 - 3.1e-17 62.6 0.0 6.2e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.6 KOO32018.1 - 7e-16 57.8 0.2 0.0066 16.4 0.0 6.3 6 0 0 6 6 6 4 Kelch motif BTB PF00651.31 KOO32018.1 - 1.5e-13 50.9 0.0 2.3e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF1668 PF07893.13 KOO32018.1 - 0.00013 21.5 0.6 1.6 8.0 0.0 4.5 1 1 4 5 5 5 1 Protein of unknown function (DUF1668) DciA PF05258.12 KOO32018.1 - 0.0048 17.3 0.0 53 4.3 0.0 4.9 5 1 0 5 5 5 0 Dna[CI] antecedent, DciA Peptidase_S9_N PF02897.15 KOO32018.1 - 0.11 11.3 0.0 5.5 5.7 0.0 2.2 1 1 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain LydB PF16084.5 KOO32020.1 - 0.094 12.5 0.1 1 9.1 0.0 2.2 1 1 1 2 2 2 0 LydA-holin antagonist FAM217 PF15344.6 KOO32020.1 - 0.27 11.1 6.6 0.35 10.8 6.6 1.1 1 0 0 1 1 1 0 FAM217 family DEAD PF00270.29 KOO32021.1 - 2.7e-41 141.2 0.0 5.4e-41 140.3 0.0 1.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase SPRY PF00622.28 KOO32021.1 - 2.2e-16 60.1 0.0 3.8e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 SPRY domain CMS1 PF14617.6 KOO32021.1 - 0.12 11.7 0.4 0.97 8.7 0.0 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit zf-CGNR PF11706.8 KOO32022.1 - 0.037 13.9 4.5 0.082 12.8 4.5 1.6 1 0 0 1 1 1 0 CGNR zinc finger adh_short PF00106.25 KOO32023.1 - 2.1e-33 115.5 0.0 2.6e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO32023.1 - 2.5e-23 82.9 0.0 3.4e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO32023.1 - 7.9e-06 25.9 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 KOO32023.1 - 0.00087 18.5 0.0 0.0011 18.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 KOO32023.1 - 0.01 15.2 0.0 0.025 14.0 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 KOO32023.1 - 0.083 12.3 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family tRNA_SAD PF07973.14 KOO32024.1 - 1.3e-09 38.0 0.7 2.2e-09 37.3 0.7 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 KOO32024.1 - 0.0045 15.6 0.0 0.0059 15.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 KOO32024.1 - 0.016 15.6 5.1 0.037 14.5 5.1 1.6 1 0 0 1 1 1 0 DHHA1 domain Gamma-thionin PF00304.20 KOO32025.1 - 8.9 6.7 9.1 3.5 7.9 6.3 1.8 2 0 0 2 2 2 0 Gamma-thionin family DnaJ PF00226.31 KOO32026.1 - 5.1e-14 52.1 0.3 1.5e-13 50.7 0.0 1.9 2 0 0 2 2 2 1 DnaJ domain Costars PF14705.6 KOO32026.1 - 0.0065 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Costars Trp_oprn_chp PF09534.10 KOO32027.1 - 0.0033 17.2 5.3 0.0047 16.7 5.3 1.2 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Trypan_PARP PF05887.11 KOO32027.1 - 0.0053 16.7 5.7 0.0074 16.3 5.7 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) BRO1 PF03097.18 KOO32027.1 - 0.069 12.0 0.6 0.075 11.8 0.6 1.0 1 0 0 1 1 1 0 BRO1-like domain 5TM-5TMR_LYT PF07694.12 KOO32027.1 - 0.16 11.5 0.1 0.19 11.2 0.1 1.1 1 0 0 1 1 1 0 5TMR of 5TMR-LYT DUF2937 PF11157.8 KOO32028.1 - 0.99 9.1 4.7 2.9 7.6 0.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2937) O-FucT PF10250.9 KOO32029.1 - 1e-08 35.3 0.0 1.2e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Holin_2-3 PF13272.6 KOO32030.1 - 0.51 10.7 25.0 6.4 7.1 0.1 6.1 6 0 0 6 6 6 0 Putative 2/3 transmembrane domain holin T4BSS_DotH_IcmK PF12293.8 KOO32031.1 - 0.05 12.8 0.1 0.086 12.1 0.1 1.4 1 0 0 1 1 1 0 Putative outer membrane core complex of type IVb secretion DUF2730 PF10805.8 KOO32031.1 - 0.23 11.6 7.6 3.8 7.7 0.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) Macoilin PF09726.9 KOO32031.1 - 0.29 9.7 3.7 0.4 9.2 3.7 1.4 1 0 0 1 1 1 0 Macoilin family PIEZO PF15917.5 KOO32031.1 - 0.96 8.9 4.1 0.41 10.1 2.0 1.6 2 0 0 2 2 2 0 Piezo TPT PF03151.16 KOO32032.1 - 4.2e-05 23.0 1.2 4.9e-05 22.8 1.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family DUF872 PF05915.12 KOO32032.1 - 0.0072 16.5 1.2 2.6 8.3 0.5 2.1 1 1 0 2 2 2 2 Eukaryotic protein of unknown function (DUF872) TPT PF03151.16 KOO32033.1 - 7.9e-13 48.4 1.7 9.5e-13 48.1 1.7 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO32033.1 - 0.0021 18.2 7.9 0.0021 18.2 7.9 1.5 2 1 0 2 2 2 1 EamA-like transporter family UAA PF08449.11 KOO32033.1 - 0.071 12.3 6.1 0.089 12.0 6.1 1.1 1 0 0 1 1 1 0 UAA transporter family APC_N_CC PF16689.5 KOO32034.1 - 0.061 13.4 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain COMM_domain PF07258.14 KOO32034.1 - 0.092 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 COMM domain E3_UFM1_ligase PF09743.9 KOO32035.1 - 2.7e-85 286.3 0.0 3e-85 286.2 0.0 1.0 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 MarR PF01047.22 KOO32035.1 - 0.026 14.5 0.0 4.8 7.2 0.0 3.2 4 0 0 4 4 4 0 MarR family HTH_9 PF08221.11 KOO32035.1 - 0.037 14.1 0.0 0.14 12.3 0.0 2.0 1 1 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain RCC1 PF00415.18 KOO32036.1 - 5.1e-43 145.5 28.8 1.9e-06 28.4 0.4 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO32036.1 - 4.5e-35 118.7 42.7 1.2e-05 24.9 0.6 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat Pep1_7 PF17232.2 KOO32036.1 - 0.013 16.0 2.9 52 4.4 0.0 6.2 8 0 0 8 8 8 0 Elicitor peptide 1-7 DUF108 PF01958.18 KOO32036.1 - 0.03 14.7 3.4 1.3e+02 3.0 0.0 5.4 7 0 0 7 7 7 0 Domain of unknown function DUF108 Babuvirus_MP PF07234.11 KOO32037.1 - 0.35 11.0 3.3 1.4 9.1 0.3 2.1 1 1 1 2 2 2 0 Movement and RNA silencing protein TIR_2 PF13676.6 KOO32038.1 - 5.1e-08 33.5 0.0 9e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 KOO32038.1 - 0.0082 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 TIR domain Acyl-CoA_dh_N PF02771.16 KOO32038.1 - 0.069 13.8 0.5 0.12 13.0 0.5 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain Nucleotid_trans PF03407.16 KOO32039.1 - 6.8e-09 36.0 0.0 2.8e-08 34.0 0.0 2.0 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase NDK PF00334.19 KOO32039.1 - 4.8e-05 23.4 0.0 0.0031 17.5 0.0 2.2 1 1 1 2 2 2 2 Nucleoside diphosphate kinase NMT_C PF02799.15 KOO32039.1 - 0.089 12.3 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Glyco_transf_34 PF05637.12 KOO32040.1 - 0.025 14.3 0.1 0.045 13.5 0.1 1.3 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family TB2_DP1_HVA22 PF03134.19 KOO32041.1 - 3.4e-15 55.7 0.1 3.4e-15 55.7 0.1 2.5 2 0 0 2 2 2 1 TB2/DP1, HVA22 family C2 PF00168.30 KOO32041.1 - 4.8e-08 33.2 0.0 3.3e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 C2 domain PDZ PF00595.24 KOO32041.1 - 9e-06 26.0 0.1 1.8e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO32041.1 - 8.6e-05 22.3 0.1 0.00027 20.7 0.1 1.9 1 0 0 1 1 1 1 PDZ domain LBR_tudor PF09465.10 KOO32042.1 - 0.00076 19.2 3.0 0.082 12.7 0.2 2.7 2 1 0 2 2 2 2 Lamin-B receptor of TUDOR domain DUF4407 PF14362.6 KOO32042.1 - 0.48 9.7 3.9 1.3 8.3 3.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EF-hand_1 PF00036.32 KOO32044.1 - 0.00051 19.4 0.5 0.0013 18.1 0.5 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO32044.1 - 0.0011 18.7 0.2 0.0034 17.2 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO32044.1 - 0.0032 17.9 0.1 0.015 15.8 0.1 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO32044.1 - 0.0032 16.9 0.0 0.0095 15.4 0.0 1.7 1 0 0 1 1 1 1 EF hand Caleosin PF05042.13 KOO32044.1 - 0.08 12.9 0.1 0.2 11.6 0.1 1.6 1 0 0 1 1 1 0 Caleosin related protein NuA4 PF09340.10 KOO32044.1 - 3.5 7.6 5.8 0.92 9.4 0.9 2.6 2 1 0 2 2 2 0 Histone acetyltransferase subunit NuA4 Hydrolase_like PF13242.6 KOO32045.1 - 0.00014 21.9 0.1 0.00022 21.2 0.1 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KOO32045.1 - 0.0033 17.8 0.0 0.0088 16.4 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOO32045.1 - 0.012 15.7 0.0 0.015 15.4 0.0 1.1 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Na_sulph_symp PF00939.19 KOO32046.1 - 7.7e-63 213.2 9.2 3.8e-62 210.9 9.2 1.8 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KOO32046.1 - 1.9e-14 53.6 36.9 1.9e-14 53.6 36.9 2.8 1 1 1 2 2 2 1 Citrate transporter DcuC PF03606.15 KOO32046.1 - 0.1 11.0 12.6 0.18 10.2 12.6 1.3 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier DUF485 PF04341.12 KOO32046.1 - 3.8 7.5 8.0 0.17 11.9 0.9 2.4 3 0 0 3 3 3 0 Protein of unknown function, DUF485 tRNA-synt_1d PF00750.19 KOO32047.1 - 1.2e-117 392.8 0.0 1.4e-117 392.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 KOO32047.1 - 8.8e-29 100.1 0.2 2.2e-28 98.8 0.2 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 KOO32047.1 - 2.6e-23 82.4 0.0 1.2e-22 80.2 0.0 2.2 3 0 0 3 3 3 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 KOO32047.1 - 0.2 11.0 0.0 0.44 9.8 0.0 1.6 1 1 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.22 KOO32047.1 - 0.3 9.3 0.0 0.53 8.5 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) EF-hand_1 PF00036.32 KOO32048.1 - 1.7e-19 67.8 5.1 0.0019 17.6 0.0 5.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 KOO32048.1 - 8.9e-16 56.4 9.8 0.0032 17.3 0.0 6.2 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.6 KOO32048.1 - 2.4e-15 56.7 11.5 2.6e-05 24.6 0.2 5.4 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO32048.1 - 6.6e-15 53.8 1.8 0.00024 20.5 0.0 5.3 5 0 0 5 5 5 4 EF hand SPARC_Ca_bdg PF10591.9 KOO32048.1 - 2.1e-07 31.3 0.0 0.00099 19.4 0.0 3.3 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KOO32048.1 - 2.7e-07 30.3 8.0 0.18 11.7 0.1 5.3 4 1 1 5 5 5 3 EF-hand domain pair Dockerin_1 PF00404.18 KOO32048.1 - 0.039 14.1 0.1 25 5.2 0.0 3.3 4 0 0 4 4 4 0 Dockerin type I domain EF-hand_9 PF14658.6 KOO32048.1 - 0.055 13.8 0.1 50 4.3 0.0 4.3 4 1 1 5 5 5 0 EF-hand domain GFRP PF06399.13 KOO32048.1 - 0.12 12.3 0.3 2.1 8.3 0.0 3.0 3 1 1 4 4 4 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) Ion_trans PF00520.31 KOO32049.1 - 1.2e-20 73.8 4.7 1.6e-20 73.4 4.7 1.1 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 KOO32049.1 - 4.9e-10 39.4 0.1 3.7e-08 33.3 0.1 2.4 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KOO32049.1 - 2e-08 34.1 2.0 4.2e-08 33.0 2.0 1.6 1 0 0 1 1 1 1 Ion channel TFIID-31kDa PF02291.15 KOO32050.1 - 2e-19 69.9 0.1 3.2e-19 69.2 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit NFRKB_winged PF14465.6 KOO32050.1 - 1.1 9.5 4.2 0.71 10.1 0.7 2.1 1 1 1 2 2 2 0 NFRKB Winged Helix-like DUF1517 PF07466.11 KOO32052.1 - 3.1e-36 125.2 0.3 4e-36 124.9 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1517) TfuA PF07812.12 KOO32055.1 - 0.19 11.5 1.7 0.42 10.4 0.2 2.4 2 0 0 2 2 2 0 TfuA-like protein Orbi_NS3 PF01616.16 KOO32055.1 - 1.2 8.8 4.5 7.3 6.2 1.2 2.3 2 0 0 2 2 2 0 Orbivirus NS3 DUF630 PF04783.12 KOO32055.1 - 5.6 7.2 13.2 42 4.4 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF630) SPX PF03105.19 KOO32056.1 - 4.8e-16 59.7 0.1 1.8e-06 28.1 0.0 3.4 2 1 1 3 3 3 2 SPX domain zf-C3HC4_2 PF13923.6 KOO32056.1 - 1.3e-08 34.6 9.8 1.3e-08 34.6 9.8 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO32056.1 - 1e-07 31.7 8.3 1e-07 31.7 8.3 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO32056.1 - 2.4e-07 30.5 6.5 2.4e-07 30.5 6.5 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO32056.1 - 1e-06 28.6 4.5 1e-06 28.6 4.5 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KOO32056.1 - 1.8e-06 28.0 9.1 1.8e-06 28.0 9.1 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KOO32056.1 - 2.1e-06 27.9 9.4 2.1e-06 27.9 9.4 2.7 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 KOO32056.1 - 0.00018 21.3 9.2 0.00018 21.3 9.2 2.2 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOO32056.1 - 0.00077 19.4 8.5 0.00077 19.4 8.5 2.3 2 1 0 2 2 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KOO32056.1 - 0.046 13.8 1.8 0.11 12.5 1.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger AIRC PF00731.20 KOO32056.1 - 0.062 12.9 0.6 0.16 11.6 0.6 1.6 1 0 0 1 1 1 0 AIR carboxylase Zn_clus PF00172.18 KOO32056.1 - 0.092 12.9 13.5 0.28 11.3 13.5 1.9 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Baculo_IE-1 PF05290.11 KOO32056.1 - 0.16 11.9 1.2 0.28 11.1 1.2 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_6 PF14835.6 KOO32056.1 - 0.44 10.5 9.3 0.045 13.6 4.4 1.9 2 0 0 2 2 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 KOO32056.1 - 1.4 8.7 9.4 0.27 11.0 4.7 2.3 2 0 0 2 2 2 0 RING-like zinc finger HlyIII PF03006.20 KOO32057.1 - 7.4e-23 81.4 12.0 7.8e-22 78.1 12.0 2.1 1 1 0 1 1 1 1 Haemolysin-III related Ephrin_rec_like PF07699.13 KOO32058.1 - 1.3e-09 37.7 16.0 3.1e-06 26.8 6.5 3.0 1 1 2 3 3 3 2 Putative ephrin-receptor like NCD3G PF07562.14 KOO32058.1 - 0.0016 18.3 4.6 0.0096 15.9 4.6 2.1 1 1 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 KOO32058.1 - 8 7.0 9.8 1.2 9.6 3.3 2.7 1 1 2 3 3 3 0 TNFR/NGFR cysteine-rich region LRR_6 PF13516.6 KOO32059.1 - 0.01 15.8 0.0 2.4 8.4 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich repeat CWC25 PF12542.8 KOO32059.1 - 0.036 15.0 0.0 0.048 14.6 0.0 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing factor LRR_4 PF12799.7 KOO32059.1 - 0.16 12.5 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) Patatin PF01734.22 KOO32060.1 - 2.7 8.1 5.5 2.3 8.3 3.4 1.8 1 1 1 2 2 2 0 Patatin-like phospholipase Cnd2 PF05786.14 KOO32061.1 - 9.2e-34 117.2 2.1 2.2e-19 69.7 2.6 4.2 3 2 0 3 3 3 3 Condensin complex subunit 2 Trypan_PARP PF05887.11 KOO32061.1 - 7.2e-05 22.8 21.1 7.2e-05 22.8 21.1 2.2 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) SPESP1 PF15754.5 KOO32061.1 - 0.064 12.4 2.0 0.12 11.6 2.0 1.4 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Transketolase_N PF00456.21 KOO32062.1 - 3.8e-149 496.2 0.0 5e-149 495.8 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 KOO32062.1 - 1.1e-40 139.2 0.0 2e-40 138.4 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 KOO32062.1 - 0.00083 18.6 0.0 0.002 17.4 0.0 1.5 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_C PF02780.20 KOO32062.1 - 0.0022 17.8 0.0 0.017 15.0 0.0 2.5 1 1 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 KOO32062.1 - 0.0038 16.2 0.1 0.0059 15.6 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 KOO32062.1 - 0.039 13.7 1.4 0.24 11.2 0.7 2.5 1 1 1 2 2 2 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Nodulin-like PF06813.13 KOO32063.1 - 1.2e-18 67.5 6.1 2.5e-18 66.5 6.1 1.5 1 0 0 1 1 1 1 Nodulin-like MFS_1 PF07690.16 KOO32063.1 - 6.8e-12 45.0 36.2 6.8e-12 45.0 36.2 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily PITH PF06201.13 KOO32065.1 - 2.7e-37 128.3 0.0 3.2e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 PITH domain TPT PF03151.16 KOO32067.1 - 3.5e-27 95.5 22.8 4.3e-27 95.2 22.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO32067.1 - 3.9e-05 23.8 35.2 0.00046 20.4 16.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family FAM176 PF14851.6 KOO32067.1 - 0.042 13.5 0.2 7.5 6.2 0.0 2.6 2 0 0 2 2 2 0 FAM176 family peroxidase PF00141.23 KOO32068.1 - 3.5e-45 154.5 0.0 5.1e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Peroxidase Mersacidin PF16934.5 KOO32068.1 - 0.069 12.9 0.2 4.1 7.2 0.0 2.5 2 0 0 2 2 2 0 Two-component Enterococcus faecalis cytolysin (EFC) SAP PF02037.27 KOO32069.1 - 3.5e-20 71.3 8.9 5.4e-11 42.0 1.1 4.0 4 1 1 5 5 5 2 SAP domain Telomere_Sde2_2 PF13297.6 KOO32069.1 - 0.008 15.8 2.2 0.18 11.5 1.5 2.4 2 0 0 2 2 2 1 Telomere stability C-terminal SAP30_Sin3_bdg PF13867.6 KOO32069.1 - 0.018 15.4 0.0 0.21 11.9 0.0 2.5 2 0 0 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 DUF3736 PF12540.8 KOO32069.1 - 0.054 13.6 0.2 0.36 10.9 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3736) AI-2E_transport PF01594.16 KOO32070.1 - 4.9e-10 39.1 10.7 4.9e-10 39.1 10.7 2.5 3 0 0 3 3 3 1 AI-2E family transporter GCP_C_terminal PF04130.13 KOO32071.1 - 3.1e-73 246.9 5.9 4.4e-73 246.4 5.9 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KOO32071.1 - 8.8e-29 101.1 0.2 4.9e-28 98.6 0.0 2.2 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal Methyltransf_16 PF10294.9 KOO32071.1 - 7.1e-08 32.4 0.0 1.3e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase EF-hand_7 PF13499.6 KOO32072.1 - 3.9e-09 36.8 0.0 0.00077 19.9 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO32072.1 - 1.6e-08 33.7 0.2 0.0065 15.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO32072.1 - 2e-08 33.2 0.4 0.0087 15.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO32072.1 - 5.7e-08 32.1 0.3 0.01 15.7 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO32072.1 - 3.6e-07 29.9 0.2 2.9e-06 27.0 0.3 2.2 2 0 0 2 2 2 1 EF-hand domain pair Polyketide_cyc PF03364.20 KOO32072.1 - 0.0026 17.9 0.0 0.0047 17.1 0.0 1.4 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport HRDC PF00570.23 KOO32073.1 - 3.9e-10 39.6 0.0 8.4e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 HRDC domain HHH PF00633.23 KOO32073.1 - 0.043 13.7 1.7 9.1 6.4 0.0 4.3 5 0 0 5 5 5 0 Helix-hairpin-helix motif dNK PF01712.19 KOO32074.1 - 2.9e-23 82.8 0.0 3.6e-23 82.5 0.0 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 KOO32074.1 - 5.4e-07 29.5 0.0 1.1e-06 28.5 0.0 1.5 1 1 0 1 1 1 1 Thymidylate kinase Herpes_TK PF00693.18 KOO32074.1 - 0.014 14.6 0.0 0.056 12.7 0.0 1.8 2 0 0 2 2 2 0 Thymidine kinase from herpesvirus FKBP_C PF00254.28 KOO32075.1 - 1.2e-06 28.7 0.0 1.7e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PDZ PF00595.24 KOO32076.1 - 9e-05 22.8 0.0 0.00099 19.4 0.0 2.6 2 1 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO32076.1 - 0.077 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 PDZ domain PDZ_6 PF17820.1 KOO32076.1 - 0.098 12.5 0.0 0.28 11.0 0.0 1.9 1 1 0 1 1 1 0 PDZ domain Ribosomal_L17 PF01196.19 KOO32077.1 - 1.5e-31 109.1 0.9 2.3e-31 108.6 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 NAD_binding_1 PF00175.21 KOO32078.1 - 1.5e-24 86.8 0.0 2.1e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOO32078.1 - 1e-16 61.1 0.0 2e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KOO32078.1 - 0.00051 20.2 0.0 0.0057 16.8 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain GMC_oxred_N PF00732.19 KOO32081.1 - 1.8e-64 218.0 0.0 2.9e-64 217.3 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOO32081.1 - 5.9e-34 117.7 0.1 9.6e-34 117.0 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 KOO32081.1 - 3.7e-06 26.3 4.8 0.00013 21.2 1.6 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 KOO32081.1 - 1.3e-05 25.3 1.1 4.6e-05 23.6 1.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO32081.1 - 6.2e-05 22.7 2.6 6.2e-05 22.7 2.6 2.2 2 1 1 3 3 3 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KOO32081.1 - 0.00029 20.0 0.2 0.00043 19.4 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 KOO32081.1 - 0.00067 19.0 1.1 0.0014 17.9 0.4 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 KOO32081.1 - 0.0036 17.0 1.0 0.0073 16.0 1.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 KOO32081.1 - 0.014 14.1 0.8 0.023 13.4 0.8 1.3 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 KOO32081.1 - 0.015 14.5 0.2 0.025 13.8 0.2 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 KOO32081.1 - 0.019 14.1 1.2 0.026 13.6 1.2 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 KOO32081.1 - 0.048 12.9 0.7 0.075 12.3 0.7 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 KOO32081.1 - 0.35 10.1 2.4 0.52 9.6 2.4 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase DUF1712 PF08217.11 KOO32082.1 - 5.9e-28 97.7 0.0 1e-22 80.4 0.0 3.1 2 1 1 3 3 3 3 Fungal domain of unknown function (DUF1712) Ribosomal_L22e PF01776.17 KOO32083.1 - 5.3e-49 165.2 2.2 7.1e-49 164.7 2.2 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family T4_Gp59_N PF08993.10 KOO32083.1 - 0.0069 16.8 0.9 0.012 16.0 0.7 1.5 1 1 0 1 1 1 1 T4 gene Gp59 loader of gp41 DNA helicase FmdA_AmdA PF03069.15 KOO32084.1 - 1.1e-89 300.9 0.0 1.3e-89 300.7 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family Tab2_like PF06485.11 KOO32085.1 - 8.3e-84 281.3 0.0 9.5e-84 281.1 0.0 1.0 1 0 0 1 1 1 1 RNA-binding protein Tab2/Atab2 FKBP_C PF00254.28 KOO32087.1 - 5e-47 158.2 0.0 2.7e-12 46.9 0.0 5.4 5 0 0 5 5 5 4 FKBP-type peptidyl-prolyl cis-trans isomerase Pro_isomerase PF00160.21 KOO32087.1 - 4.7e-42 143.9 0.0 8.3e-42 143.1 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.6 KOO32087.1 - 7.3e-15 54.4 9.7 0.00055 19.6 0.0 4.7 4 0 0 4 4 4 3 TPR repeat TPR_1 PF00515.28 KOO32087.1 - 3.7e-09 36.0 25.9 0.0047 16.7 0.2 7.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO32087.1 - 8.5e-09 34.9 28.8 0.034 14.2 0.2 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO32087.1 - 1.8e-05 24.6 9.8 0.045 14.0 0.4 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO32087.1 - 3.2e-05 24.4 14.0 0.0045 17.5 2.6 4.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO32087.1 - 0.0014 18.9 0.4 0.11 13.0 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO32087.1 - 0.0015 19.2 18.7 0.25 12.0 1.4 4.7 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO32087.1 - 0.0028 18.3 9.7 0.93 10.5 0.3 5.1 4 1 0 4 4 3 1 Tetratricopeptide repeat FKBP_N_2 PF18023.1 KOO32087.1 - 0.0048 17.0 0.0 2.8 8.1 0.0 3.7 3 0 0 3 3 3 1 BDBT FKBP like N-terminal TPR_MalT PF17874.1 KOO32087.1 - 0.016 14.6 4.5 0.34 10.2 0.1 2.5 2 0 0 2 2 2 0 MalT-like TPR region MIT PF04212.18 KOO32087.1 - 0.039 14.0 7.1 3.3 7.8 0.1 4.2 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_9 PF13371.6 KOO32087.1 - 0.07 13.3 7.8 1.2 9.3 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO32087.1 - 0.078 13.1 5.4 4.5 7.4 0.1 3.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 KOO32087.1 - 1.3 9.8 7.2 58 4.6 0.9 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO32087.1 - 3.1 8.1 20.8 2.8 8.3 0.2 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Metallophos PF00149.28 KOO32090.1 - 5.5e-10 40.1 0.0 1.3e-09 38.9 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOO32090.1 - 1.8e-06 28.2 0.0 3.3e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain 3HCDH_N PF02737.18 KOO32092.1 - 2.1e-30 105.9 1.6 7.5e-30 104.1 0.7 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 KOO32092.1 - 8.4e-30 103.3 0.0 9.1e-21 74.3 0.0 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Kinesin PF00225.23 KOO32093.1 - 9.8e-97 323.8 0.1 1.7e-96 323.0 0.0 1.4 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOO32093.1 - 1.2e-48 164.8 0.0 2.7e-48 163.7 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 KOO32093.1 - 0.016 15.6 0.0 0.016 15.6 0.0 2.6 2 1 0 2 2 1 0 AAA ATPase domain rRNA_proc-arch PF13234.6 KOO32093.1 - 0.036 14.0 1.2 0.15 12.0 0.0 2.2 2 0 0 2 2 2 0 rRNA-processing arch domain DUF4407 PF14362.6 KOO32093.1 - 0.066 12.6 15.0 0.11 11.8 15.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KASH_CCD PF14662.6 KOO32093.1 - 0.095 12.5 18.7 0.16 11.8 18.7 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Golgin_A5 PF09787.9 KOO32093.1 - 0.31 10.5 16.2 0.58 9.6 16.2 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 AAA_22 PF13401.6 KOO32093.1 - 0.38 11.0 0.0 0.38 11.0 0.0 2.5 2 1 0 2 2 2 0 AAA domain V_ATPase_I PF01496.19 KOO32093.1 - 0.44 8.4 1.3 0.68 7.8 1.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 KOO32093.1 - 2.1 8.5 4.9 4.9 7.3 4.9 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 KOO32093.1 - 2.2 7.5 17.3 0.57 9.4 13.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Syntaxin-6_N PF09177.11 KOO32093.1 - 3.7 8.2 10.0 18 6.0 10.0 2.2 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TBCA PF02970.16 KOO32093.1 - 3.9 7.9 14.6 26 5.2 14.4 2.4 1 1 0 1 1 1 0 Tubulin binding cofactor A FUSC PF04632.12 KOO32093.1 - 4 5.9 15.7 8.2 4.8 15.7 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family DASH_Spc19 PF08287.11 KOO32093.1 - 4.8 7.1 20.5 0.28 11.0 14.6 1.9 2 0 0 2 2 2 0 Spc19 Atg14 PF10186.9 KOO32093.1 - 5.3 6.0 15.3 8.4 5.4 13.3 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TFIIA PF03153.13 KOO32093.1 - 5.7 6.8 7.2 10 6.0 7.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2937 PF11157.8 KOO32093.1 - 6.9 6.4 7.4 17 5.1 7.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) AAA_12 PF13087.6 KOO32094.1 - 1.4e-28 99.9 0.0 2.1e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO32094.1 - 3e-22 79.7 0.0 1.7e-15 57.5 0.0 2.8 2 1 0 2 2 2 2 AAA domain WW PF00397.26 KOO32094.1 - 7e-09 35.6 10.6 1.4e-05 25.1 4.1 2.6 2 0 0 2 2 2 2 WW domain AAA_30 PF13604.6 KOO32094.1 - 2e-05 24.4 1.6 0.022 14.5 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 KOO32094.1 - 4.6e-05 23.8 0.1 0.06 13.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOO32094.1 - 0.024 15.0 0.2 2.6 8.4 0.0 3.2 2 0 0 2 2 2 0 AAA ATPase domain DEAD PF00270.29 KOO32094.1 - 0.06 13.1 0.1 3.3 7.5 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_22 PF13401.6 KOO32094.1 - 0.063 13.6 0.6 0.85 9.9 0.0 2.7 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 KOO32094.1 - 0.064 12.5 0.1 0.17 11.1 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) zf-NADH-PPase PF09297.11 KOO32094.1 - 0.069 12.8 0.1 0.25 11.1 0.1 2.0 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_9 PF14369.6 KOO32094.1 - 0.16 12.2 1.5 0.46 10.8 1.5 1.7 1 0 0 1 1 1 0 zinc-ribbon DUF2478 PF10649.9 KOO32097.1 - 0.023 14.3 0.0 0.074 12.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2478) zf-C2H2 PF00096.26 KOO32097.1 - 0.16 12.4 0.2 0.16 12.4 0.2 2.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type NDK PF00334.19 KOO32100.1 - 4.4e-05 23.5 0.0 0.0023 18.0 0.0 2.5 2 0 0 2 2 2 2 Nucleoside diphosphate kinase Hydrolase_6 PF13344.6 KOO32101.1 - 9.9e-30 102.6 0.0 1.6e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO32101.1 - 2e-19 69.4 0.0 6.1e-19 67.9 0.0 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 KOO32101.1 - 6.1e-11 43.0 0.2 2e-10 41.3 0.1 2.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOO32101.1 - 7.8e-07 29.3 0.1 0.007 16.5 0.0 2.9 3 1 1 4 4 4 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 KOO32101.1 - 0.0069 16.0 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Acid_phosphat_B PF03767.14 KOO32101.1 - 0.16 11.6 0.1 0.34 10.5 0.1 1.5 1 1 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) OTU PF02338.19 KOO32103.1 - 2.1e-15 57.3 0.0 4.7e-15 56.2 0.0 1.5 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 KOO32103.1 - 0.033 13.6 0.2 4.8 6.6 0.1 2.1 1 1 1 2 2 2 0 Peptidase C65 Otubain SAP PF02037.27 KOO32104.1 - 0.086 12.6 0.1 2.9 7.8 0.2 2.5 2 0 0 2 2 2 0 SAP domain FKBP_C PF00254.28 KOO32105.1 - 9.8e-18 64.3 0.0 1.7e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 KOO32105.1 - 0.003 18.1 0.0 0.0059 17.1 0.0 1.5 1 0 0 1 1 1 1 Nucleoplasmin-like domain Ribosomal_L6e PF01159.19 KOO32106.1 - 1.1e-34 119.3 0.0 1.5e-34 118.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e Choline_transpo PF04515.12 KOO32107.1 - 1.9e-72 244.2 26.6 1.9e-72 244.2 26.6 1.8 2 0 0 2 2 2 1 Plasma-membrane choline transporter PHO4 PF01384.20 KOO32107.1 - 3 6.8 10.9 6.9 5.6 10.9 1.6 1 1 0 1 1 1 0 Phosphate transporter family DUF563 PF04577.14 KOO32108.1 - 0.00011 22.4 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) TPR_1 PF00515.28 KOO32109.1 - 0.00028 20.6 0.2 1.2 9.1 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat ATG16 PF08614.11 KOO32109.1 - 0.0071 16.6 7.8 0.0071 16.6 7.8 8.9 6 2 3 9 9 9 2 Autophagy protein 16 (ATG16) Spc29 PF17082.5 KOO32109.1 - 5.8 6.7 9.1 0.54 10.1 0.1 3.4 3 0 0 3 3 3 0 Spindle Pole Component 29 Apolipoprotein PF01442.18 KOO32110.1 - 0.41 10.5 24.1 2 8.3 6.1 3.9 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Hamartin PF04388.12 KOO32110.1 - 0.53 8.9 2.6 0.7 8.5 2.6 1.1 1 0 0 1 1 1 0 Hamartin protein Mga PF05043.13 KOO32111.1 - 0.1 13.2 0.5 18 6.0 0.1 2.6 2 0 0 2 2 2 0 Mga helix-turn-helix domain Pre-PUA PF17832.1 KOO32111.1 - 0.31 11.8 2.0 9.5 7.0 0.2 3.3 3 0 0 3 3 3 0 Pre-PUA-like domain DUF4407 PF14362.6 KOO32111.1 - 3.1 7.1 75.8 0.074 12.4 22.1 4.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) V-SNARE_C PF12352.8 KOO32111.1 - 3.3 8.1 7.8 1.8 8.9 0.8 3.0 2 1 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Fez1 PF06818.15 KOO32111.1 - 5.6 7.4 64.0 27 5.1 18.5 5.3 1 1 5 6 6 6 0 Fez1 AAA PF00004.29 KOO32113.1 - 4.3e-06 27.2 0.0 1e-05 26.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_6 PF17866.1 KOO32113.1 - 0.0011 19.1 2.2 0.0032 17.6 2.2 1.8 1 0 0 1 1 1 1 AAA lid domain AAA_7 PF12775.7 KOO32113.1 - 0.029 13.9 0.0 0.053 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 KOO32113.1 - 0.033 13.9 0.4 0.099 12.4 0.4 1.7 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 KOO32113.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Torsin PF06309.11 KOO32113.1 - 0.19 11.8 0.0 0.46 10.6 0.0 1.6 1 0 0 1 1 1 0 Torsin PBP_like_2 PF12849.7 KOO32116.1 - 3.7e-47 161.4 0.2 6.3e-47 160.6 0.1 1.4 1 1 0 1 1 1 1 PBP superfamily domain RNA_pol_L PF01193.24 KOO32116.1 - 0.14 11.6 0.2 0.35 10.3 0.2 1.7 1 1 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Beta_helix PF13229.6 KOO32117.1 - 2.6e-11 43.6 11.0 6.2e-11 42.4 11.0 1.6 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 KOO32117.1 - 2.7e-05 23.5 2.3 4.2e-05 22.9 2.3 1.2 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) SNF2_N PF00176.23 KOO32118.1 - 4.4e-20 71.7 0.0 6.6e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Nuc_recep-AF1 PF11825.8 KOO32118.1 - 3.2 7.8 5.3 55 3.9 5.3 2.3 1 1 0 1 1 1 0 Nuclear/hormone receptor activator site AF-1 Rick_17kDa_Anti PF05433.15 KOO32119.1 - 0.0021 17.9 1.1 0.0042 16.9 1.1 1.6 1 0 0 1 1 1 1 Glycine zipper 2TM domain Helicase_C PF00271.31 KOO32119.1 - 0.01 16.2 0.0 0.03 14.6 0.0 1.8 1 1 0 1 1 1 0 Helicase conserved C-terminal domain Bacteriocin_IIc PF10439.9 KOO32119.1 - 0.067 13.3 0.6 0.17 12.0 0.6 1.6 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide FOXP-CC PF16159.5 KOO32119.1 - 0.13 12.9 0.1 7.3 7.3 0.0 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain Pkinase PF00069.25 KOO32120.1 - 2.6e-21 76.2 0.0 3.8e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32120.1 - 1.6e-19 70.2 0.0 4.5e-19 68.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 KOO32120.1 - 0.034 13.8 0.0 1.9 8.1 0.0 2.1 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Wzy_C PF04932.15 KOO32120.1 - 0.07 12.8 0.1 0.099 12.3 0.1 1.2 1 0 0 1 1 1 0 O-Antigen ligase Rrn6 PF10214.9 KOO32120.1 - 0.088 11.3 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Stevor PF17410.2 KOO32120.1 - 0.13 11.8 1.6 0.26 10.8 1.6 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Insulin_TMD PF17870.1 KOO32120.1 - 0.14 12.3 1.5 0.26 11.4 1.5 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF2755 PF10954.8 KOO32120.1 - 0.17 11.9 1.2 0.35 10.8 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2755) MtrF PF09472.10 KOO32120.1 - 0.19 11.2 4.0 0.42 10.0 4.0 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Adeno_E3_CR2 PF02439.15 KOO32120.1 - 0.23 11.2 7.2 0.44 10.3 7.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Syndecan PF01034.20 KOO32120.1 - 0.34 10.9 1.8 0.75 9.8 1.8 1.5 1 0 0 1 1 1 0 Syndecan domain RIFIN PF02009.16 KOO32120.1 - 2.7 7.8 7.0 0.37 10.6 3.2 1.5 2 0 0 2 2 2 0 Rifin His_Phos_1 PF00300.22 KOO32121.1 - 1e-65 221.1 2.1 1.2e-25 90.3 0.0 4.4 3 1 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) SprA-related PF12118.8 KOO32121.1 - 0.073 12.2 0.3 0.11 11.6 0.3 1.2 1 0 0 1 1 1 0 SprA-related family WD40 PF00400.32 KOO32122.1 - 5.7e-20 71.3 12.6 0.0004 21.1 1.2 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO32122.1 - 3.2e-10 40.2 0.0 0.29 11.5 0.0 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Topoisom_bac PF01131.20 KOO32124.1 - 0.00013 21.2 0.0 0.00016 20.8 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Rotamase_3 PF13616.6 KOO32125.1 - 1.3e-14 54.7 0.0 1.4e-14 54.6 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 KOO32125.1 - 2.1e-12 47.8 0.0 2.3e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain PRR20 PF15708.5 KOO32125.1 - 0.089 12.7 0.0 0.095 12.6 0.0 1.0 1 0 0 1 1 1 0 Proline-rich protein family 20 Lactonase PF10282.9 KOO32127.1 - 8.1e-58 196.3 0.0 2.4e-55 188.2 0.0 2.3 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Emaravirus_P4 PF16505.5 KOO32129.1 - 0.13 11.3 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 P4 movement protein of Emaravirus, and the 30K superfamily 2-oxoacid_dh PF00198.23 KOO32130.1 - 3.6e-74 249.1 0.2 4.7e-74 248.7 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KOO32130.1 - 5.5e-16 58.2 1.3 1.2e-15 57.1 1.3 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 KOO32130.1 - 1.6e-07 31.5 0.2 4.3e-07 30.2 0.2 1.8 1 0 0 1 1 1 1 e3 binding domain zf-C4H2 PF10146.9 KOO32131.1 - 0.0029 18.0 1.1 0.0029 18.0 1.1 2.3 1 1 1 2 2 2 1 Zinc finger-containing protein rRNA_proc-arch PF13234.6 KOO32131.1 - 0.15 11.9 7.2 0.52 10.2 2.0 2.3 2 0 0 2 2 2 0 rRNA-processing arch domain DUF16 PF01519.16 KOO32131.1 - 0.94 10.0 7.4 0.26 11.8 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 HAP1_N PF04849.13 KOO32131.1 - 2.1 7.5 23.8 34 3.5 0.0 3.1 2 1 0 2 2 2 0 HAP1 N-terminal conserved region Peptidase_S46 PF10459.9 KOO32131.1 - 2.7 6.5 16.0 3.9 6.0 16.0 1.2 1 0 0 1 1 1 0 Peptidase S46 ThiS PF02597.20 KOO32131.1 - 5 7.9 6.6 1.3 9.8 0.8 2.8 1 1 0 2 2 2 0 ThiS family PsbP PF01789.16 KOO32132.1 - 0.087 13.0 0.1 0.21 11.7 0.1 1.7 1 1 0 1 1 1 0 PsbP NUMOD3 PF07460.11 KOO32133.1 - 4.3e-18 65.2 7.7 1.8e-13 50.5 0.1 4.8 5 0 0 5 5 5 3 NUMOD3 motif (2 copies) HSP70 PF00012.20 KOO32134.1 - 7.8e-21 73.9 0.0 1.1e-20 73.4 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein RRM_1 PF00076.22 KOO32135.1 - 1.9e-31 107.7 0.1 1.6e-12 47.0 0.0 3.9 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 KOO32135.1 - 3.9e-09 36.4 1.1 8.4e-09 35.4 1.1 1.5 1 0 0 1 1 1 1 WW domain RRM_7 PF16367.5 KOO32135.1 - 7.7e-08 32.4 0.0 0.012 15.7 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KOO32135.1 - 0.00011 22.1 0.1 0.27 11.2 0.0 3.0 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KOO32135.1 - 0.00017 21.6 0.0 0.073 13.1 0.0 3.0 3 1 0 3 3 3 1 RNA binding motif RRM_5 PF13893.6 KOO32135.1 - 0.057 13.0 0.0 9.1 5.9 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4651 PF15513.6 KOO32135.1 - 0.077 12.8 0.1 17 5.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4651) PCI PF01399.27 KOO32136.1 - 1.9e-06 28.3 2.3 3.3e-05 24.3 0.1 3.4 3 0 0 3 3 3 1 PCI domain ACP_PD PF04336.12 KOO32136.1 - 0.26 11.7 3.6 0.41 11.1 0.2 3.1 2 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase HATPase_c PF02518.26 KOO32137.1 - 0.00051 20.5 0.0 0.038 14.5 0.0 2.6 1 1 1 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 PF00183.18 KOO32137.1 - 0.074 11.9 2.7 0.1 11.5 2.7 1.1 1 0 0 1 1 1 0 Hsp90 protein EF-hand_1 PF00036.32 KOO32138.1 - 3.9e-05 22.9 0.1 7.8e-05 21.9 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO32138.1 - 0.00036 20.2 0.1 0.0009 19.0 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO32138.1 - 0.011 15.2 0.0 0.03 13.8 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO32138.1 - 0.013 16.0 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair DUF294_C PF10335.9 KOO32138.1 - 0.086 12.6 3.5 0.17 11.7 1.8 2.4 2 0 0 2 2 2 0 Putative nucleotidyltransferase substrate binding domain Glyco_transf_34 PF05637.12 KOO32138.1 - 0.087 12.5 0.0 0.89 9.2 0.0 2.4 3 0 0 3 3 3 0 galactosyl transferase GMA12/MNN10 family TipAS PF07739.13 KOO32138.1 - 4.5 7.9 6.1 2.5 8.7 1.1 2.6 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain TPR_12 PF13424.6 KOO32140.1 - 1.9e-06 28.1 7.8 1.9e-06 28.1 7.8 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO32140.1 - 0.00086 19.1 3.2 0.00086 19.1 3.2 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat SHIPPO-rpt PF07004.12 KOO32141.1 - 0.64 11.0 61.6 0.13 13.2 2.4 11.9 13 1 0 13 13 13 0 Sperm-tail PG-rich repeat MMADHC PF10229.9 KOO32142.1 - 0.00011 22.0 0.0 0.00024 20.9 0.0 1.6 1 1 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein GIT_CC PF16559.5 KOO32145.1 - 0.014 15.3 0.1 0.024 14.5 0.0 1.5 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor YL1 PF05764.13 KOO32145.1 - 0.03 14.5 0.1 0.042 14.0 0.1 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DUF4140 PF13600.6 KOO32145.1 - 0.047 14.1 0.9 0.048 14.1 0.9 1.0 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Mito_fiss_reg PF05308.11 KOO32145.1 - 0.062 13.4 0.5 0.069 13.2 0.4 1.3 1 1 0 1 1 1 0 Mitochondrial fission regulator PIP5K PF01504.18 KOO32146.1 - 3.1e-46 157.8 0.0 1.8e-45 155.3 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Seryl_tRNA_N PF02403.22 KOO32147.1 - 0.35 11.1 12.4 0.041 14.1 2.7 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain OHCU_decarbox PF09349.10 KOO32147.1 - 2.7 8.4 10.4 18 5.8 10.4 2.0 1 1 0 1 1 1 0 OHCU decarboxylase EF-hand_6 PF13405.6 KOO32148.1 - 1.4e-56 183.6 17.8 5.1e-07 29.1 0.1 13.3 13 0 0 13 13 13 11 EF-hand domain EF-hand_1 PF00036.32 KOO32148.1 - 1.8e-52 171.0 21.8 2.9e-07 29.6 0.2 13.3 13 0 0 13 13 13 7 EF hand EF-hand_7 PF13499.6 KOO32148.1 - 8.4e-43 144.7 27.9 6.4e-07 29.7 0.2 11.0 6 3 6 12 12 12 10 EF-hand domain pair EF-hand_5 PF13202.6 KOO32148.1 - 1.6e-26 90.6 49.5 3.8e-06 26.2 0.0 10.4 12 0 0 12 12 11 6 EF hand EF-hand_8 PF13833.6 KOO32148.1 - 6.6e-24 83.5 27.2 9e-05 22.2 0.0 10.1 7 4 3 10 10 10 7 EF-hand domain pair EF-hand_9 PF14658.6 KOO32148.1 - 5e-06 26.7 0.4 7.9 6.9 0.0 6.1 6 0 0 6 6 6 1 EF-hand domain Sigma_reg_C PF13791.6 KOO32148.1 - 3.4e-05 24.1 0.0 17 5.6 0.0 5.7 6 0 0 6 6 6 0 Sigma factor regulator C-terminal p25-alpha PF05517.12 KOO32148.1 - 0.0009 19.4 0.3 6.8 6.8 0.0 5.0 6 0 0 6 6 6 1 p25-alpha DUF615 PF04751.14 KOO32148.1 - 0.0023 17.9 8.0 0.69 9.9 0.2 4.6 5 0 0 5 5 5 2 Protein of unknown function (DUF615) HAUS4 PF14735.6 KOO32148.1 - 0.0032 17.2 10.0 2.8 7.6 0.1 5.7 7 0 0 7 7 7 2 HAUS augmin-like complex subunit 4 DDT PF02791.17 KOO32148.1 - 0.0073 16.6 4.8 19 5.6 0.0 5.4 6 0 0 6 6 6 0 DDT domain EF-hand_4 PF12763.7 KOO32148.1 - 0.0086 16.0 20.9 4.8 7.2 0.0 7.5 6 2 2 8 8 8 1 Cytoskeletal-regulatory complex EF hand DUF111 PF01969.17 KOO32148.1 - 0.014 14.5 0.1 32 3.5 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function DUF111 EF-hand_10 PF14788.6 KOO32148.1 - 0.018 14.9 9.1 6.2 6.8 0.0 6.0 6 0 0 6 6 6 0 EF hand SAM_KSR1 PF13543.6 KOO32148.1 - 0.065 13.4 3.4 6.8 6.8 0.0 3.9 5 0 0 5 5 4 0 SAM like domain present in kinase suppressor RAS 1 DOG1 PF14144.6 KOO32148.1 - 0.071 13.3 4.8 4.4 7.6 0.0 4.0 4 0 0 4 4 3 0 Seed dormancy control Peptidase_C65 PF10275.9 KOO32148.1 - 0.092 12.2 0.0 11 5.3 0.0 3.3 3 0 0 3 3 3 0 Peptidase C65 Otubain DUF2458 PF10454.9 KOO32148.1 - 1.1 8.9 5.8 10 5.7 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2458) DUF4242 PF14026.6 KOO32148.1 - 1.3 9.3 3.5 23 5.3 0.0 4.6 6 0 0 6 6 5 0 Protein of unknown function (DUF4242) Vps5 PF09325.10 KOO32148.1 - 2.6 7.5 16.6 0.49 9.9 0.1 4.5 5 0 0 5 5 5 0 Vps5 C terminal like EF-hand_6 PF13405.6 KOO32149.1 - 1.7e-30 102.3 7.3 3e-06 26.7 0.2 7.5 7 0 0 7 7 7 6 EF-hand domain EF-hand_1 PF00036.32 KOO32149.1 - 7.9e-30 100.2 13.7 3.6e-06 26.1 1.1 7.5 7 0 0 7 7 7 5 EF hand EF-hand_7 PF13499.6 KOO32149.1 - 7.4e-22 77.6 16.3 3.3e-05 24.2 0.5 6.2 2 2 3 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO32149.1 - 8.8e-14 50.3 21.2 0.0004 19.8 0.6 5.4 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO32149.1 - 1.5e-13 50.3 18.4 0.00054 19.7 0.8 5.7 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_4 PF12763.7 KOO32149.1 - 0.00058 19.8 12.1 0.94 9.5 0.1 5.3 3 3 3 6 6 6 2 Cytoskeletal-regulatory complex EF hand Sigma_reg_C PF13791.6 KOO32149.1 - 0.00086 19.5 0.0 7.7 6.7 0.0 4.0 4 0 0 4 4 4 1 Sigma factor regulator C-terminal EF-hand_11 PF08976.11 KOO32149.1 - 0.0031 18.3 0.4 1.4 9.8 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain Lipoprotein_10 PF03202.13 KOO32149.1 - 0.0079 16.6 1.2 1.6 9.1 0.2 2.4 2 0 0 2 2 2 1 Putative mycoplasma lipoprotein, C-terminal region MLTR_LBD PF17765.1 KOO32149.1 - 0.012 15.7 2.1 0.028 14.6 2.1 1.6 1 0 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain Peptidase_S66 PF02016.15 KOO32149.1 - 0.16 12.1 0.0 3.5 7.8 0.0 2.8 2 0 0 2 2 2 0 LD-carboxypeptidase N-terminal domain DUF5319 PF17252.2 KOO32150.1 - 0.022 15.0 0.1 0.042 14.1 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5319) TFIIE-A_C PF11521.8 KOO32150.1 - 3.4 8.0 7.0 21 5.5 0.9 3.1 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha Ank_2 PF12796.7 KOO32152.1 - 1.1e-09 38.7 0.0 1e-07 32.5 0.0 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO32152.1 - 3.3e-06 27.0 0.1 0.15 12.7 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 KOO32152.1 - 7e-05 23.3 0.0 0.00015 22.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO32152.1 - 0.00035 20.9 0.2 0.088 13.3 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 KOO32152.1 - 0.0011 19.2 0.1 0.007 16.7 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Pkinase PF00069.25 KOO32154.1 - 1.1e-50 172.5 0.0 5.7e-35 120.9 0.0 3.0 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32154.1 - 5.5e-23 81.6 0.0 5.6e-19 68.4 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 KOO32154.1 - 5.4e-06 25.9 0.0 0.0029 17.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 KOO32154.1 - 0.00091 18.6 0.0 0.0053 16.1 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO32154.1 - 0.017 15.1 0.3 0.017 15.1 0.3 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.22 KOO32154.1 - 0.073 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 KOO32154.1 - 0.078 12.6 0.0 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Neisseria_TspB PF05616.13 KOO32154.1 - 0.18 10.2 1.8 0.27 9.7 1.8 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein RRM_1 PF00076.22 KOO32155.1 - 2.9e-50 167.9 0.0 9.3e-14 51.0 0.0 4.2 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOO32155.1 - 0.00067 19.7 0.0 0.71 10.0 0.0 3.6 3 1 1 4 4 4 1 RNA recognition motif PHM7_cyt PF14703.6 KOO32155.1 - 0.0037 17.5 0.7 21 5.3 0.0 4.3 4 1 1 5 5 5 1 Cytosolic domain of 10TM putative phosphate transporter RNA_bind PF08675.11 KOO32155.1 - 0.083 12.9 0.0 3.7 7.7 0.0 3.1 3 0 0 3 3 3 0 RNA binding domain RRM_occluded PF16842.5 KOO32155.1 - 0.087 12.7 0.0 15 5.6 0.0 2.8 3 0 0 3 3 3 0 Occluded RNA-recognition motif Sacchrp_dh_NADP PF03435.18 KOO32156.1 - 4.6e-14 52.8 0.2 7.6e-14 52.1 0.2 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain PTPLA PF04387.14 KOO32156.1 - 2e-10 40.7 0.9 3.4e-10 39.9 0.9 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA EF-hand_1 PF00036.32 KOO32158.1 - 9.4e-19 65.5 0.6 6.7e-09 34.7 0.4 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO32158.1 - 8.9e-15 54.3 1.1 6.2e-14 51.6 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO32158.1 - 1.1e-13 49.9 0.1 1.8e-06 27.4 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO32158.1 - 2.3e-13 50.4 0.0 4e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO32158.1 - 9.5e-10 37.5 4.8 0.0001 21.6 0.0 2.6 2 1 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO32158.1 - 2.7e-07 30.8 0.0 4.5e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO32158.1 - 0.00015 21.7 0.0 0.00026 20.9 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO32158.1 - 0.02 15.2 0.0 0.033 14.5 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3349 PF11829.8 KOO32158.1 - 0.079 13.7 0.1 9.2 7.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) EF-hand_11 PF08976.11 KOO32158.1 - 0.14 13.1 0.0 0.32 11.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain OAD_gamma PF04277.13 KOO32158.1 - 2.4 8.8 0.0 2.4 8.8 0.0 3.6 2 1 0 2 2 1 0 Oxaloacetate decarboxylase, gamma chain Pyridoxal_deC PF00282.19 KOO32159.1 - 2.5e-14 52.8 0.0 3.7e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 KOO32159.1 - 1.5e-07 30.8 0.0 4.2e-07 29.3 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V Herpes_TAF50 PF03326.13 KOO32161.1 - 2.4 6.7 7.0 4 6.0 1.5 2.0 2 0 0 2 2 2 0 Herpesvirus transcription activation factor (transactivator) Acetyltransf_7 PF13508.7 KOO32163.1 - 7.2e-10 39.2 0.0 3.5e-09 36.9 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO32163.1 - 3.7e-09 36.6 0.0 6.8e-09 35.7 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO32163.1 - 4.9e-09 36.4 0.0 1.5e-08 34.9 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 KOO32163.1 - 0.00012 21.9 0.0 0.00041 20.3 0.0 1.9 1 1 1 2 2 2 1 FR47-like protein DnaJ PF00226.31 KOO32164.1 - 0.00022 21.3 0.0 0.00058 19.9 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain HhH-GPD PF00730.25 KOO32165.1 - 2.3e-16 60.2 0.0 3.6e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KOO32165.1 - 8.1e-07 28.6 0.3 2.1e-06 27.3 0.1 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif zf-C2H2 PF00096.26 KOO32166.1 - 0.029 14.8 3.3 0.29 11.7 0.0 3.5 3 1 0 3 3 3 0 Zinc finger, C2H2 type EF-hand_7 PF13499.6 KOO32167.1 - 9.9e-14 51.5 2.2 2.2e-09 37.6 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO32167.1 - 3.2e-12 45.1 0.2 9.4e-05 21.7 0.0 2.6 2 0 0 2 2 2 2 EF hand Metallophos PF00149.28 KOO32167.1 - 5.8e-12 46.5 0.0 1.1e-11 45.6 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_6 PF13405.6 KOO32167.1 - 7.1e-11 41.1 0.1 0.00074 19.2 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO32167.1 - 1.7e-09 36.8 0.5 0.00057 19.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO32167.1 - 1.5e-08 34.3 0.2 0.003 17.4 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair tRNA-synt_1c PF00749.21 KOO32168.1 - 1.1e-93 313.6 0.0 1.6e-93 313.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KOO32168.1 - 4e-28 98.4 0.0 3.5e-26 92.1 0.0 2.4 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Peptidase_M10 PF00413.24 KOO32169.1 - 0.0013 18.6 0.0 0.0031 17.4 0.0 1.7 2 0 0 2 2 2 1 Matrixin Metallopep PF12044.8 KOO32169.1 - 0.078 11.6 1.0 0.12 10.9 1.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Ceramidase PF05875.12 KOO32169.1 - 0.2 11.1 2.9 0.16 11.3 1.1 1.7 2 0 0 2 2 2 0 Ceramidase Pkinase PF00069.25 KOO32172.1 - 2.1e-31 109.3 0.0 4.4e-31 108.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32172.1 - 7.7e-12 45.0 0.0 1.4e-10 40.9 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO32172.1 - 0.031 13.0 0.1 0.25 10.1 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 KOO32172.1 - 0.078 12.9 10.0 0.12 12.3 0.0 3.5 3 0 0 3 3 3 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO32172.1 - 0.092 12.0 0.0 0.34 10.2 0.0 1.8 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 KOO32172.1 - 0.15 11.4 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PIF1 PF05970.14 KOO32173.1 - 5.1e-55 187.1 0.5 9.5e-45 153.3 0.0 2.6 2 1 1 3 3 3 2 PIF1-like helicase AAA_30 PF13604.6 KOO32173.1 - 1.5e-17 63.9 0.2 1.5e-16 60.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOO32173.1 - 1.1e-11 45.3 0.1 7e-11 42.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain HRDC PF00570.23 KOO32173.1 - 2.1e-06 27.6 0.0 5.8e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 HRDC domain AAA_22 PF13401.6 KOO32173.1 - 0.0012 19.1 0.0 0.0045 17.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 KOO32173.1 - 0.012 15.1 0.0 0.032 13.7 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_5 PF07728.14 KOO32173.1 - 0.013 15.5 0.0 0.37 10.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 KOO32173.1 - 0.017 14.2 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein UvrD-helicase PF00580.21 KOO32173.1 - 0.075 12.5 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain LEA_6 PF10714.9 KOO32173.1 - 0.18 11.9 0.1 0.48 10.5 0.1 1.7 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 Viral_helicase1 PF01443.18 KOO32173.1 - 0.21 11.3 0.3 4.4 7.0 0.1 2.6 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TPR_1 PF00515.28 KOO32173.1 - 0.26 11.2 5.5 5.2 7.1 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO32173.1 - 0.28 11.5 15.1 0.39 11.0 3.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat AAA_11 PF13086.6 KOO32173.1 - 0.42 10.4 2.8 4.4 7.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 KOO32173.1 - 0.82 10.0 6.1 0.29 11.5 0.1 3.1 2 1 0 2 2 2 0 AAA ATPase domain RRM_1 PF00076.22 KOO32174.1 - 0.0096 15.7 0.0 0.023 14.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_19 PF13245.6 KOO32174.1 - 0.066 13.5 0.6 0.18 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 KOO32174.1 - 0.23 10.6 0.0 2.1 7.5 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 CinA PF02464.17 KOO32175.1 - 0.0065 16.0 0.4 0.0083 15.7 0.4 1.2 1 0 0 1 1 1 1 Competence-damaged protein VCBS PF13517.6 KOO32177.1 - 3.2e-157 511.3 177.9 2.8e-14 53.4 4.0 18.8 4 3 15 19 19 19 19 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO32177.1 - 3.9e-87 285.9 186.8 2.8e-05 24.1 1.8 20.7 20 0 0 20 20 20 20 FG-GAP repeat Ephrin_rec_like PF07699.13 KOO32177.1 - 4.4e-12 45.6 82.8 4.2e-06 26.4 8.5 10.3 2 1 3 9 9 9 6 Putative ephrin-receptor like Dockerin_1 PF00404.18 KOO32177.1 - 2.2e-07 31.0 65.4 16 5.8 0.0 18.0 18 2 2 20 20 20 4 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO32177.1 - 1.3e-06 27.9 92.7 2.7 7.3 0.1 19.1 5 3 14 20 20 20 14 Insecticide toxin TcdB middle/N-terminal region CPBP PF02517.16 KOO32178.1 - 3.3e-16 59.4 5.4 3.3e-16 59.4 5.4 2.5 2 1 1 3 3 3 1 CPBP intramembrane metalloprotease zf-Nse PF11789.8 KOO32179.1 - 1.9e-05 24.4 0.1 3.7e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 KOO32179.1 - 0.0098 15.7 0.7 0.025 14.4 0.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO32179.1 - 0.011 15.7 0.1 0.027 14.5 0.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger BCDHK_Adom3 PF10436.9 KOO32179.1 - 0.02 14.7 0.1 0.033 14.0 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Usp PF00582.26 KOO32179.1 - 0.025 15.1 0.7 0.053 14.0 0.6 1.6 1 1 0 1 1 1 0 Universal stress protein family zf-RING_2 PF13639.6 KOO32179.1 - 0.096 13.0 0.3 0.36 11.2 0.1 2.1 1 1 1 2 2 2 0 Ring finger domain Rtf2 PF04641.12 KOO32179.1 - 0.74 9.1 8.7 0.094 12.1 2.9 2.0 1 1 1 2 2 2 0 Rtf2 RING-finger DUF4407 PF14362.6 KOO32180.1 - 0.063 12.6 48.6 0.084 12.2 9.2 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 KOO32180.1 - 0.16 10.8 51.6 0.49 9.2 16.2 3.9 2 2 2 4 4 4 0 Spc7 kinetochore protein FIVAR PF07554.13 KOO32180.1 - 0.25 12.2 0.0 0.25 12.2 0.0 3.1 3 1 0 3 3 3 0 FIVAR domain BRI3BP PF14965.6 KOO32180.1 - 0.77 9.3 4.1 4.6 6.7 0.1 3.0 3 0 0 3 3 3 0 Negative regulator of p53/TP53 GAS PF13851.6 KOO32180.1 - 0.78 9.0 46.9 0.24 10.7 19.9 3.9 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding UvrD_C PF13361.6 KOO32180.1 - 0.98 8.7 16.0 2.5 7.4 3.0 2.3 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain DUF3972 PF13118.6 KOO32180.1 - 1.6 9.2 14.3 5 7.6 0.2 4.2 4 1 0 4 4 4 0 Protein of unknown function (DUF3972) IQ PF00612.27 KOO32181.1 - 3.2e-08 32.6 57.3 0.32 10.9 0.1 9.4 8 0 0 8 8 8 8 IQ calmodulin-binding motif RNA_pol_Rpb4 PF03874.16 KOO32182.1 - 9.3e-17 61.5 0.1 1.1e-16 61.2 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Vps54_N PF10475.9 KOO32182.1 - 0.03 13.6 0.1 0.053 12.8 0.1 1.3 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex SET PF00856.28 KOO32183.1 - 1.4e-15 58.1 0.0 4e-15 56.6 0.0 1.8 1 0 0 1 1 1 1 SET domain Cys_Met_Meta_PP PF01053.20 KOO32184.1 - 9e-137 455.7 0.0 1e-136 455.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 KOO32184.1 - 3e-06 26.8 0.8 6.7e-06 25.6 0.5 1.7 1 1 1 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 KOO32184.1 - 7.9e-06 25.1 0.0 2.5e-05 23.4 0.1 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Pkinase PF00069.25 KOO32185.1 - 3.5e-43 147.9 0.0 7.6e-43 146.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32185.1 - 3e-18 66.1 0.0 4.2e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO32185.1 - 0.23 10.7 0.0 0.48 9.7 0.0 1.5 1 0 0 1 1 1 0 Kinase-like DUF5107 PF17128.4 KOO32187.1 - 5.3e-18 65.2 0.0 4.7e-16 58.8 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF5107) SIX1_SD PF16878.5 KOO32187.1 - 0.0068 16.9 0.0 0.011 16.3 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Myosin_head PF00063.21 KOO32188.1 - 2.9e-136 455.4 0.0 4.1e-136 454.9 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) DUF2599 PF10783.9 KOO32188.1 - 0.26 11.9 0.1 0.26 11.9 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2599) TAF4 PF05236.14 KOO32188.1 - 0.6 9.8 10.1 1.1 8.9 10.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF1635 PF07795.11 KOO32188.1 - 1.1 9.1 7.1 0.77 9.6 5.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF4200 PF13863.6 KOO32188.1 - 1.4 9.3 10.0 3.1 8.2 10.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) AAA_12 PF13087.6 KOO32190.1 - 1.3e-42 145.7 0.0 1.7e-42 145.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KOO32190.1 - 4.9e-06 26.3 0.1 1.3e-05 24.9 0.1 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain PARP PF00644.20 KOO32191.1 - 5.7e-14 52.2 0.0 1.3e-13 50.9 0.0 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain MHB PF16525.5 KOO32191.1 - 0.0025 18.0 0.2 2.2 8.6 0.2 2.9 2 0 0 2 2 2 2 Haemophore, haem-binding SNF5 PF04855.12 KOO32193.1 - 0.0044 16.8 0.0 0.0082 16.0 0.0 1.5 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 Chloroa_b-bind PF00504.21 KOO32196.1 - 1.4e-24 87.5 0.2 6.6e-24 85.3 0.0 2.1 2 1 0 2 2 2 1 Chlorophyll A-B binding protein U-box PF04564.15 KOO32197.1 - 0.043 14.0 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 U-box domain GIT_CC PF16559.5 KOO32197.1 - 0.15 12.0 0.1 0.15 12.0 0.1 7.3 6 1 2 8 8 8 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc7 PF08317.11 KOO32197.1 - 0.8 8.5 110.2 0.0069 15.3 22.6 6.0 3 2 4 7 7 7 0 Spc7 kinetochore protein Myb_DNA-binding PF00249.31 KOO32198.1 - 3.8e-29 100.6 1.6 6.9e-14 51.8 0.2 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO32198.1 - 9.5e-20 70.6 0.0 7.8e-12 45.3 0.0 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO32198.1 - 0.015 15.2 0.0 0.036 14.0 0.0 1.6 2 0 0 2 2 2 0 Myb DNA-binding like FB_lectin PF07367.11 KOO32198.1 - 0.022 14.7 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 Fungal fruit body lectin Trypsin_2 PF13365.6 KOO32199.1 - 7.3e-22 78.9 4.1 7.3e-22 78.9 4.1 1.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain ClpS PF02617.17 KOO32199.1 - 2.9e-06 27.0 0.0 5.4e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS Trypsin PF00089.26 KOO32199.1 - 0.00015 21.6 0.0 0.00036 20.4 0.0 1.6 1 1 0 1 1 1 1 Trypsin Peptidase_S32 PF05579.13 KOO32199.1 - 3.3 6.8 7.6 2.2 7.4 3.8 2.3 2 1 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Myb_DNA-binding PF00249.31 KOO32200.1 - 2e-26 91.9 0.0 1.7e-12 47.3 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO32200.1 - 2e-21 76.0 0.0 2.6e-10 40.4 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO32200.1 - 8.4e-07 28.8 0.0 0.019 14.8 0.0 2.2 2 0 0 2 2 2 2 Myb DNA-binding like Myb_DNA-bind_2 PF08914.11 KOO32200.1 - 0.014 15.6 0.9 1.3 9.3 0.1 2.9 2 2 0 2 2 2 0 Rap1 Myb domain TRAPP PF04051.16 KOO32201.1 - 8.1e-34 116.4 0.1 9.5e-34 116.2 0.1 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Pkinase PF00069.25 KOO32202.1 - 5.6e-72 242.3 0.0 7.8e-72 241.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32202.1 - 4.5e-38 131.0 0.0 6.3e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO32202.1 - 1e-06 28.3 0.3 2.1e-06 27.3 0.0 1.7 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 KOO32202.1 - 1.9e-05 24.4 0.5 3.6e-05 23.4 0.5 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KOO32202.1 - 0.00029 20.3 1.0 0.00069 19.0 1.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOO32202.1 - 0.00062 19.4 0.3 0.0012 18.5 0.3 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 KOO32202.1 - 0.0064 16.4 0.2 0.0064 16.4 0.2 2.7 3 1 1 4 4 4 1 Phosphotransferase enzyme family Vitellogenin_N PF01347.22 KOO32202.1 - 0.5 8.7 3.0 2 6.7 3.0 1.9 1 1 0 1 1 1 0 Lipoprotein amino terminal region SET PF00856.28 KOO32203.1 - 6.2e-09 36.5 0.0 9.3e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 SET domain DLIC PF05783.11 KOO32203.1 - 0.83 8.4 4.3 0.45 9.3 1.8 1.7 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) Chloroa_b-bind PF00504.21 KOO32204.1 - 5.7e-26 92.0 0.0 3e-25 89.6 0.0 1.9 1 1 0 1 1 1 1 Chlorophyll A-B binding protein WD40 PF00400.32 KOO32205.1 - 1e-45 152.8 20.6 1.8e-09 38.1 0.1 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO32205.1 - 2.3e-16 59.8 1.7 0.004 17.4 0.0 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO32205.1 - 9.4e-05 22.4 0.1 0.087 12.7 0.0 3.1 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOO32205.1 - 0.012 14.6 0.1 10 5.0 0.0 4.0 2 1 3 6 6 6 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WDCP PF15390.6 KOO32205.1 - 0.019 13.4 0.4 0.029 12.8 0.4 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family IKI3 PF04762.12 KOO32205.1 - 0.029 12.4 0.1 0.27 9.2 0.0 2.0 2 0 0 2 2 2 0 IKI3 family DUF3551 PF12071.8 KOO32205.1 - 0.17 12.0 2.3 0.27 11.3 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3551) ROK PF00480.20 KOO32207.1 - 8.6e-30 104.2 1.4 1e-29 104.0 1.4 1.0 1 0 0 1 1 1 1 ROK family Galactosyl_T PF01762.21 KOO32209.1 - 2.7e-05 24.1 0.0 6.5e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Galactosyltransferase Ldl_recept_b PF00058.17 KOO32209.1 - 0.00098 19.6 0.0 0.037 14.5 0.0 3.1 3 0 0 3 3 3 1 Low-density lipoprotein receptor repeat class B Acylphosphatase PF00708.18 KOO32210.1 - 9.3e-09 35.6 0.0 0.00045 20.6 0.0 3.0 2 1 1 3 3 3 2 Acylphosphatase Sec23_helical PF04815.15 KOO32211.1 - 1.5e-13 50.5 0.0 2.4e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 KOO32211.1 - 4.1e-08 33.0 0.0 6.2e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Gelsolin repeat Pkinase PF00069.25 KOO32212.1 - 3.1e-48 164.4 0.0 4.8e-48 163.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO32212.1 - 5.1e-25 87.4 3.7 9.9e-12 44.8 0.1 3.3 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO32212.1 - 1.4e-20 73.7 0.0 2.9e-20 72.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase RGS PF00615.19 KOO32212.1 - 2.3e-05 24.6 0.0 0.00028 21.2 0.0 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Kinase-like PF14531.6 KOO32212.1 - 0.0091 15.3 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DUF4888 PF16229.5 KOO32212.1 - 0.013 15.5 0.1 0.025 14.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4888) APH PF01636.23 KOO32212.1 - 0.11 12.4 0.0 0.11 12.4 0.0 3.0 3 0 0 3 3 3 0 Phosphotransferase enzyme family UQ_con PF00179.26 KOO32213.1 - 5.2e-52 175.2 0.0 7.3e-30 103.4 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO32213.1 - 7e-07 29.0 0.0 0.016 14.9 0.0 2.5 2 0 0 2 2 2 2 Prokaryotic E2 family B RWD PF05773.22 KOO32213.1 - 3.8e-06 27.2 0.0 0.02 15.2 0.0 2.4 2 0 0 2 2 2 2 RWD domain UEV PF05743.13 KOO32213.1 - 2.2e-05 24.3 0.1 0.0016 18.3 0.0 2.5 2 0 0 2 2 2 1 UEV domain Amidohydro_1 PF01979.20 KOO32214.1 - 4.6e-13 49.2 0.2 6.1e-13 48.8 0.2 1.0 1 0 0 1 1 1 1 Amidohydrolase family Baculo_LEF-11 PF06385.12 KOO32214.1 - 0.17 12.4 0.1 0.3 11.6 0.1 1.3 1 0 0 1 1 1 0 Baculovirus LEF-11 protein DnaJ PF00226.31 KOO32216.1 - 3.7e-06 26.9 1.3 1.5e-05 25.0 0.0 2.5 2 0 0 2 2 2 1 DnaJ domain z-alpha PF02295.17 KOO32216.1 - 0.074 13.1 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 Adenosine deaminase z-alpha domain VP_N-CPKC PF11475.8 KOO32216.1 - 0.95 9.4 4.6 8.5 6.4 0.1 3.3 3 0 0 3 3 3 0 Virion protein N terminal domain Bestrophin PF01062.21 KOO32217.1 - 2.4e-40 138.8 1.2 3.1e-40 138.4 1.2 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel YWFCY PF14293.6 KOO32217.1 - 0.081 13.2 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 YWFCY protein COesterase PF00135.28 KOO32218.1 - 6.3e-86 289.3 0.0 8.3e-86 288.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KOO32218.1 - 5.3e-09 36.2 5.1 0.0011 18.8 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold UPF0020 PF01170.18 KOO32220.1 - 1.5e-06 28.0 0.0 0.0098 15.6 0.1 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 KOO32220.1 - 0.00061 19.6 0.0 0.017 14.8 0.0 2.1 2 0 0 2 2 2 1 DNA methylase Cons_hypoth95 PF03602.15 KOO32220.1 - 0.018 14.7 0.0 5.7 6.5 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical protein 95 DAO PF01266.24 KOO32221.1 - 9e-15 55.1 1.7 1.1e-14 54.9 1.7 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase MscS_porin PF12795.7 KOO32222.1 - 0.0051 16.4 5.0 0.0053 16.3 3.9 1.6 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain HR1 PF02185.16 KOO32222.1 - 0.015 15.4 0.4 10 6.3 0.7 2.6 2 1 0 2 2 2 0 Hr1 repeat Macoilin PF09726.9 KOO32222.1 - 0.36 9.3 1.9 0.47 9.0 1.9 1.1 1 0 0 1 1 1 0 Macoilin family TetR_C_15 PF17918.1 KOO32222.1 - 0.7 10.7 8.7 0.53 11.1 4.8 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain JAKMIP_CC3 PF16034.5 KOO32222.1 - 2 8.3 6.6 20 5.1 6.5 2.3 1 1 0 1 1 1 0 JAKMIP CC3 domain PH PF00169.29 KOO32223.1 - 1.7e-08 34.9 0.0 3e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KOO32223.1 - 0.00021 21.5 0.2 0.00056 20.1 0.1 1.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 KOO32223.1 - 0.06 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Mcp5_PH PF12814.7 KOO32223.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology LMBR1 PF04791.16 KOO32225.1 - 2.1e-60 205.1 0.0 2.9e-60 204.6 0.0 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein LrgA PF03788.14 KOO32225.1 - 0.017 15.0 1.0 0.06 13.3 1.0 1.9 1 0 0 1 1 1 0 LrgA family PMP22_Claudin PF00822.20 KOO32225.1 - 0.05 13.5 0.9 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family betaPIX_CC PF16523.5 KOO32225.1 - 0.32 10.9 3.3 0.22 11.3 0.5 1.9 2 0 0 2 2 2 0 betaPIX coiled coil UPF0669 PF17065.5 KOO32226.1 - 0.016 15.0 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Putative cytokine, C6ORF120 PPC PF04151.15 KOO32226.1 - 0.069 14.3 0.0 0.18 12.9 0.0 1.7 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain PSI_PsaE PF02427.17 KOO32227.1 - 5.1e-31 106.1 0.3 6.2e-31 105.9 0.3 1.1 1 0 0 1 1 1 1 Photosystem I reaction centre subunit IV / PsaE EF-hand_7 PF13499.6 KOO32228.1 - 1.4e-13 51.0 7.8 2.3e-07 31.2 2.0 3.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO32228.1 - 6e-12 44.2 6.5 0.00048 19.5 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO32228.1 - 2.5e-11 42.6 3.8 0.0016 18.2 0.2 4.1 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KOO32228.1 - 5.2e-11 41.5 11.0 0.00021 20.6 0.4 4.4 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO32228.1 - 3.9e-10 39.4 6.9 0.0022 17.8 0.4 3.8 3 1 0 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 KOO32228.1 - 0.014 15.7 0.1 4.3 7.7 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO32228.1 - 0.018 15.4 0.4 0.085 13.2 0.2 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1997 PF09366.10 KOO32229.1 - 9.7e-09 35.5 0.0 1.7e-08 34.7 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1997) Thioredoxin_8 PF13905.6 KOO32230.1 - 5.7e-56 186.9 0.0 7.5e-28 96.7 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 KOO32230.1 - 5.6e-20 71.5 0.0 1.5e-09 37.8 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.10 KOO32230.1 - 1.1e-17 64.1 0.0 3.9e-09 36.4 0.0 2.5 1 1 1 2 2 2 2 Redoxin Thioredoxin PF00085.20 KOO32230.1 - 1.5e-14 53.9 0.0 0.00015 21.7 0.0 4.2 3 1 0 4 4 4 3 Thioredoxin Thioredoxin_2 PF13098.6 KOO32230.1 - 7.6e-14 52.1 0.0 2.1e-06 28.2 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KOO32230.1 - 0.0021 17.9 0.0 1.9 8.2 0.0 3.7 2 2 0 2 2 2 1 Thioredoxin TraF PF13728.6 KOO32230.1 - 0.0042 16.9 0.0 4.2 7.1 0.0 2.7 2 2 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 KOO32230.1 - 0.026 14.7 0.1 2.7 8.2 0.0 2.9 2 2 0 2 2 2 0 Thioredoxin-like Peptidase_M16_M PF16187.5 KOO32230.1 - 0.03 13.6 0.0 0.3 10.4 0.0 2.0 2 0 0 2 2 2 0 Middle or third domain of peptidase_M16 DUF1906 PF08924.11 KOO32230.1 - 0.077 13.1 0.0 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1906) NADH_4Fe-4S PF10589.9 KOO32230.1 - 0.18 11.9 0.0 32 4.7 0.0 2.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region AAA_30 PF13604.6 KOO32232.1 - 2.1e-30 105.9 0.0 7.2e-30 104.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO32232.1 - 1.4e-20 74.1 0.1 4.6e-20 72.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 KOO32232.1 - 5.8e-17 61.3 0.3 2e-16 59.6 0.1 2.1 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain HHH_4 PF14490.6 KOO32232.1 - 9.4e-13 48.0 0.0 2.4e-11 43.5 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix containing domain SH3_13 PF18335.1 KOO32232.1 - 1.3e-10 40.9 0.1 2.5e-08 33.6 0.0 2.4 2 0 0 2 2 2 1 ATP-dependent RecD-like DNA helicase SH3 domain Viral_helicase1 PF01443.18 KOO32232.1 - 5.2e-08 32.9 0.2 0.00013 21.8 0.0 2.8 2 1 1 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD_C PF13361.6 KOO32232.1 - 0.0068 15.8 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 KOO32232.1 - 0.0099 15.7 0.1 0.021 14.7 0.1 1.5 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 KOO32232.1 - 0.097 13.3 0.2 0.39 11.3 0.2 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix domain EF-hand_6 PF13405.6 KOO32234.1 - 1e-18 65.5 5.3 0.00022 20.9 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO32234.1 - 1.7e-18 66.8 1.0 6.6e-10 39.3 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO32234.1 - 7.9e-18 62.6 5.7 0.00025 20.4 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO32234.1 - 6.8e-14 51.5 1.9 6.2e-06 26.0 0.2 3.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO32234.1 - 2.7e-11 42.4 7.0 0.0097 15.4 0.0 5.0 5 0 0 5 5 5 3 EF hand EF-hand_9 PF14658.6 KOO32234.1 - 0.0038 17.5 0.0 0.23 11.8 0.0 3.3 2 0 0 2 2 2 1 EF-hand domain SH3_3 PF08239.11 KOO32234.1 - 0.013 15.8 0.0 0.039 14.2 0.0 1.8 1 0 0 1 1 1 0 Bacterial SH3 domain Myb_DNA-binding PF00249.31 KOO32235.1 - 3.9e-24 84.6 8.1 5.6e-13 48.8 2.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO32235.1 - 6.4e-17 61.6 3.8 2.9e-08 33.8 3.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO32235.1 - 0.00062 19.6 0.1 0.2 11.6 0.2 2.2 2 0 0 2 2 2 2 Myb DNA-binding like DUF4872 PF16169.5 KOO32235.1 - 1.2 8.9 5.2 42 3.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4872) LRR_6 PF13516.6 KOO32236.1 - 4e-25 85.7 54.7 0.0016 18.4 0.0 16.8 17 0 0 17 17 17 7 Leucine Rich repeat EF-hand_1 PF00036.32 KOO32236.1 - 3.9e-14 51.0 2.1 5.2e-07 28.8 0.2 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO32236.1 - 1.2e-13 49.8 1.4 8.7e-07 28.4 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO32236.1 - 8.5e-09 35.1 3.1 2.4e-07 30.5 0.5 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO32236.1 - 9.4e-09 35.6 0.8 3.4e-08 33.8 0.8 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO32236.1 - 4.1e-08 32.3 3.8 0.0011 18.4 0.2 2.8 2 0 0 2 2 2 2 EF hand LRR_4 PF12799.7 KOO32236.1 - 5.6e-08 33.0 28.7 0.057 13.9 1.2 9.7 9 1 1 10 10 9 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO32236.1 - 0.00071 19.3 33.4 0.68 9.7 1.4 9.0 6 3 3 9 9 9 4 Leucine rich repeat LRR_1 PF00560.33 KOO32236.1 - 0.0017 18.7 13.8 63 4.7 0.0 9.6 10 1 0 10 10 9 0 Leucine Rich Repeat NACHT PF05729.12 KOO32236.1 - 0.0022 17.9 0.9 0.04 13.8 0.9 3.1 2 1 0 2 2 2 1 NACHT domain UvrD-helicase PF00580.21 KOO32236.1 - 0.0027 17.3 0.3 0.2 11.2 0.1 2.4 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 KOO32236.1 - 0.073 13.4 2.0 0.11 12.8 0.1 2.4 2 0 0 2 2 1 0 AAA domain EF-hand_9 PF14658.6 KOO32236.1 - 0.089 13.1 0.0 0.29 11.5 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain AAA PF00004.29 KOO32236.1 - 0.11 12.9 0.0 0.43 11.0 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Pantoate_ligase PF02569.15 KOO32236.1 - 9.8 5.3 7.2 21 4.2 7.2 1.5 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase Asp_Arg_Hydrox PF05118.15 KOO32238.1 - 1e-38 132.6 0.0 1.7e-38 131.9 0.0 1.4 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase ANAPC3 PF12895.7 KOO32238.1 - 0.013 15.8 0.1 0.031 14.5 0.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Lipase_3 PF01764.25 KOO32239.1 - 1.1e-19 70.8 0.0 1.4e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 KOO32239.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF3089 PF11288.8 KOO32239.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) VCBS PF13517.6 KOO32240.1 - 1.4e-76 253.0 86.3 1.1e-13 51.6 4.2 9.3 3 2 6 9 9 9 9 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO32240.1 - 9.1e-45 150.4 88.8 6.9e-06 26.1 1.8 9.9 10 0 0 10 10 10 9 FG-GAP repeat Dockerin_1 PF00404.18 KOO32240.1 - 1.2e-09 38.2 24.7 13 6.1 0.0 9.2 9 0 0 9 9 9 5 Dockerin type I domain HET-s_218-289 PF11558.8 KOO32240.1 - 1.7e-06 27.9 0.0 7.1 6.7 0.0 7.4 9 0 0 9 9 9 1 Het-s 218-289 BBS1 PF14779.6 KOO32240.1 - 0.006 16.1 3.8 35 3.7 0.0 6.7 9 0 0 9 9 9 0 Ciliary BBSome complex subunit 1 EF-hand_1 PF00036.32 KOO32240.1 - 0.0085 15.6 36.2 27 4.6 0.1 9.3 9 0 0 9 9 9 0 EF hand TcdB_toxin_midN PF12256.8 KOO32240.1 - 0.024 14.0 47.9 0.86 8.9 0.3 9.0 3 3 6 9 9 9 0 Insecticide toxin TcdB middle/N-terminal region DUF756 PF05506.12 KOO32240.1 - 0.086 13.8 0.0 37 5.3 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF756) Tuberculin PF12198.8 KOO32240.1 - 5 7.3 12.4 1.6 8.9 1.4 3.0 2 0 0 2 2 2 0 Theoretical tuberculin protein EF-hand_5 PF13202.6 KOO32240.1 - 6.1 6.5 57.4 7.5 6.2 0.3 9.4 9 0 0 9 9 9 0 EF hand VCBS PF13517.6 KOO32242.1 - 3.1e-32 111.0 36.4 9.9e-15 54.9 6.6 3.1 1 1 3 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO32242.1 - 1.8e-17 63.1 21.8 1.2e-05 25.3 3.8 3.5 3 0 0 3 3 3 3 FG-GAP repeat Dockerin_1 PF00404.18 KOO32242.1 - 1.7e-05 24.9 3.7 2.1 8.6 0.1 3.3 3 0 0 3 3 3 3 Dockerin type I domain EF-hand_1 PF00036.32 KOO32242.1 - 0.0025 17.2 7.0 5.7 6.7 0.2 3.3 3 0 0 3 3 3 3 EF hand TcdB_toxin_midN PF12256.8 KOO32242.1 - 0.0048 16.3 11.7 0.63 9.4 0.3 3.1 1 1 1 3 3 3 3 Insecticide toxin TcdB middle/N-terminal region EF-hand_5 PF13202.6 KOO32242.1 - 0.0073 15.8 14.3 2.1 8.0 0.7 3.5 3 0 0 3 3 3 3 EF hand HET-s_218-289 PF11558.8 KOO32242.1 - 0.084 12.9 0.0 5.8 7.0 0.0 2.9 3 0 0 3 3 3 0 Het-s 218-289 Itfg2 PF15907.5 KOO32242.1 - 0.17 10.9 0.2 3.7 6.5 0.0 2.6 3 0 0 3 3 3 0 Integrin-alpha FG-GAP repeat-containing protein 2 Peptidase_C41 PF05417.11 KOO32242.1 - 0.18 11.6 0.8 9.7 6.0 0.0 2.9 1 1 1 3 3 3 0 Hepatitis E cysteine protease BBS1 PF14779.6 KOO32242.1 - 0.19 11.1 1.6 14 5.1 0.0 2.9 1 1 0 3 3 3 0 Ciliary BBSome complex subunit 1 EF-hand_6 PF13405.6 KOO32242.1 - 2.1 8.5 6.0 89 3.4 0.1 3.3 3 0 0 3 3 3 0 EF-hand domain VID27 PF08553.10 KOO32244.1 - 0.0028 16.8 0.0 0.0036 16.4 0.0 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain WD40 PF00400.32 KOO32244.1 - 0.024 15.5 0.0 17 6.5 0.0 2.9 2 0 0 2 2 2 0 WD domain, G-beta repeat CBFD_NFYB_HMF PF00808.23 KOO32245.1 - 5.3e-08 33.0 1.2 0.00079 19.7 0.1 2.4 2 0 0 2 2 2 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOO32245.1 - 6.5e-06 26.5 2.1 0.054 13.9 0.1 2.3 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 HTH_AsnC-type PF13404.6 KOO32245.1 - 0.00086 19.1 0.9 0.44 10.4 0.1 2.8 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain AAA_lid_4 PF17864.1 KOO32245.1 - 0.044 13.5 0.4 15 5.4 0.0 2.7 2 0 0 2 2 2 0 RuvB AAA lid domain TAFII28 PF04719.14 KOO32245.1 - 0.046 13.8 2.2 3.7 7.7 0.2 2.2 2 0 0 2 2 2 0 hTAFII28-like protein conserved region Bromo_TP PF07524.13 KOO32245.1 - 0.1 12.6 0.3 20 5.3 0.1 2.4 2 0 0 2 2 2 0 Bromodomain associated DUF1441 PF07278.11 KOO32245.1 - 0.12 12.3 0.1 4.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1441) RRM_1 PF00076.22 KOO32246.1 - 3.1e-12 46.1 0.0 4.8e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 KOO32246.1 - 0.0014 18.9 0.7 0.0035 17.6 0.7 1.7 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RNAse_A_bac PF18431.1 KOO32246.1 - 0.025 15.5 0.1 0.062 14.3 0.0 1.6 2 0 0 2 2 2 0 Bacterial CdiA-CT RNAse A domain RRM_7 PF16367.5 KOO32246.1 - 0.073 13.2 0.0 0.13 12.4 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif Limkain-b1 PF11608.8 KOO32246.1 - 0.14 12.2 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Limkain b1 EF-hand_6 PF13405.6 KOO32247.1 - 3.9e-10 38.8 0.1 0.0012 18.6 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO32247.1 - 3.1e-09 37.2 2.3 9.5e-07 29.2 0.4 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO32247.1 - 2.6e-08 32.8 1.0 0.0035 16.8 0.3 2.7 2 0 0 2 2 2 2 EF hand Ank_2 PF12796.7 KOO32247.1 - 1.1e-06 29.1 0.5 0.072 13.7 0.1 2.9 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO32247.1 - 1.4e-06 28.4 0.8 0.04 14.2 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) EF-hand_8 PF13833.6 KOO32247.1 - 1.3e-05 24.9 0.0 4.6e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair Ank_3 PF13606.6 KOO32247.1 - 0.0037 17.6 0.2 3.8 8.4 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 KOO32247.1 - 0.0037 17.8 0.2 0.31 11.7 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) ART PF01129.18 KOO32247.1 - 0.034 13.4 0.0 0.082 12.2 0.0 1.6 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase Ank PF00023.30 KOO32247.1 - 0.058 13.9 0.1 6.9 7.3 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat EF-hand_5 PF13202.6 KOO32247.1 - 0.1 12.1 1.1 1.9 8.1 0.1 2.6 2 0 0 2 2 2 0 EF hand Sec5 PF15469.6 KOO32247.1 - 8.7 6.1 7.8 18 5.1 0.4 2.7 2 0 0 2 2 2 0 Exocyst complex component Sec5 ArfGap PF01412.18 KOO32248.1 - 2.8e-28 98.3 1.6 3.4e-28 98.1 1.6 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 KOO32248.1 - 0.14 12.4 0.2 0.14 12.4 0.2 2.7 3 0 0 3 3 3 0 B-box zinc finger GRDA PF04723.14 KOO32248.1 - 0.14 11.9 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A PKD_channel PF08016.12 KOO32250.1 - 1.5e-26 93.1 11.8 3.2e-25 88.7 13.5 1.9 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 KOO32250.1 - 4.6e-12 45.7 15.9 6.1e-12 45.3 15.9 1.1 1 0 0 1 1 1 1 Ion transport protein SlyX PF04102.12 KOO32250.1 - 0.078 13.6 0.5 0.2 12.3 0.0 1.8 2 0 0 2 2 2 0 SlyX ATP-gua_Ptrans PF00217.19 KOO32251.1 - 1.6e-26 93.1 0.0 2.6e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 KOO32251.1 - 4e-22 78.4 0.0 6.9e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain LRR_4 PF12799.7 KOO32251.1 - 3.7e-08 33.5 4.5 0.22 12.0 0.6 6.7 7 0 0 7 7 7 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO32251.1 - 1.3e-07 31.1 13.0 0.034 14.2 0.2 7.9 8 0 0 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.33 KOO32251.1 - 0.0016 18.7 5.8 55 4.9 0.1 6.6 6 1 1 7 7 7 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO32251.1 - 0.067 13.0 15.4 1.4 8.7 1.0 6.0 7 0 0 7 7 7 0 Leucine rich repeat SecA_SW PF07516.13 KOO32252.1 - 9.9e-33 113.9 0.1 1.7e-32 113.1 0.1 1.4 1 0 0 1 1 1 1 SecA Wing and Scaffold domain SecA_PP_bind PF01043.20 KOO32252.1 - 2.4e-26 92.5 0.0 6.9e-26 91.1 0.0 1.8 1 0 0 1 1 1 1 SecA preprotein cross-linking domain SecA_DEAD PF07517.14 KOO32252.1 - 1.1e-14 54.4 0.2 1.9e-13 50.4 0.1 2.3 2 0 0 2 2 2 1 SecA DEAD-like domain Peptidase_M60 PF13402.6 KOO32252.1 - 0.074 12.6 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase M60, enhancin and enhancin-like Helicase_C PF00271.31 KOO32252.1 - 0.099 13.0 0.2 2.9 8.3 0.0 2.5 2 0 0 2 2 2 0 Helicase conserved C-terminal domain acVLRF1 PF18859.1 KOO32252.1 - 0.43 10.9 8.1 5.8 7.2 0.3 3.5 3 0 0 3 3 3 0 Actinobacteria/chloroflexi VLRF1 release factor SecA_DEAD PF07517.14 KOO32253.1 - 2.4e-94 315.9 0.1 2.9e-94 315.6 0.1 1.0 1 0 0 1 1 1 1 SecA DEAD-like domain DEAD PF00270.29 KOO32253.1 - 0.0002 21.2 0.0 0.00031 20.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Tnp_22_trimer PF17489.2 KOO32253.1 - 0.48 10.4 1.7 0.6 10.1 0.6 1.7 1 1 1 2 2 2 0 L1 transposable element trimerization domain COesterase PF00135.28 KOO32254.1 - 9.9e-14 51.1 0.0 1.1e-13 50.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family DUF5047 PF16466.5 KOO32254.1 - 0.12 12.7 0.2 0.27 11.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5047) Pro_isomerase PF00160.21 KOO32255.1 - 3.3e-37 128.2 0.0 5.3e-37 127.5 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ank_2 PF12796.7 KOO32255.1 - 4.1e-17 62.5 2.2 7.6e-09 36.0 0.1 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) FKBP_C PF00254.28 KOO32255.1 - 1.3e-09 38.3 0.0 2.9e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Ank_5 PF13857.6 KOO32255.1 - 3.9e-09 36.6 0.8 7.6e-07 29.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Nucleoporin_FG PF13634.6 KOO32255.1 - 6.3e-06 27.0 103.4 0.83 10.5 46.1 5.4 1 1 2 3 3 3 1 Nucleoporin FG repeat region Ank PF00023.30 KOO32255.1 - 9.4e-06 25.8 0.4 0.24 11.9 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KOO32255.1 - 9.8e-05 22.5 0.0 0.088 13.4 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 KOO32255.1 - 0.0026 18.3 0.5 1 10.0 0.1 2.9 2 1 0 3 3 3 1 Ankyrin repeats (many copies) Microvir_lysis PF04517.12 KOO32255.1 - 0.088 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Microvirus lysis protein (E), C terminus EGF_2 PF07974.13 KOO32258.1 - 1.6e-28 98.7 221.3 0.00014 22.1 7.2 13.1 11 2 1 12 12 12 10 EGF-like domain EGF_Tenascin PF18720.1 KOO32258.1 - 2.4e-07 30.6 184.2 0.0022 18.0 10.9 12.8 12 0 0 12 12 12 7 Tenascin EGF domain DUF1045 PF06299.12 KOO32258.1 - 0.27 11.2 1.7 0.51 10.3 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1045) EGF PF00008.27 KOO32258.1 - 4.8 7.6 191.7 0.24 11.7 12.3 13.4 13 1 0 13 13 13 0 EGF-like domain Lipase_3 PF01764.25 KOO32259.1 - 1.3e-17 64.0 0.0 2.1e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.20 KOO32259.1 - 0.12 12.0 1.0 6.3 6.4 0.1 2.3 2 0 0 2 2 2 0 Putative esterase Sporozoite_P67 PF05642.11 KOO32259.1 - 0.57 8.2 1.6 0.8 7.7 1.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen HC2 PF07382.11 KOO32260.1 - 0.0094 16.1 15.8 0.0094 16.1 15.8 2.6 3 0 0 3 3 3 1 Histone H1-like nucleoprotein HC2 Glyco_transf_34 PF05637.12 KOO32260.1 - 0.033 13.9 0.1 0.072 12.8 0.1 1.5 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family DUF3139 PF11337.8 KOO32260.1 - 0.056 14.1 0.3 0.19 12.4 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) AP2 PF00847.20 KOO32261.1 - 0.14 12.4 0.8 0.3 11.4 0.8 1.6 1 0 0 1 1 1 0 AP2 domain Sec16_N PF12935.7 KOO32261.1 - 2.3 8.3 9.7 3.2 7.9 4.6 2.1 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 N-terminus SBBP PF06739.11 KOO32262.1 - 0.0022 18.0 11.1 0.077 13.0 0.4 3.3 3 0 0 3 3 3 3 Beta-propeller repeat PKD_channel PF08016.12 KOO32263.1 - 6.5e-29 100.9 13.3 6.5e-29 100.9 13.3 2.3 3 0 0 3 3 3 1 Polycystin cation channel Ion_trans PF00520.31 KOO32263.1 - 8.1e-12 44.9 15.6 1.3e-11 44.2 15.6 1.3 1 0 0 1 1 1 1 Ion transport protein Peroxin-13_N PF04088.13 KOO32263.1 - 0.39 11.0 0.0 0.39 11.0 0.0 2.1 3 0 0 3 3 3 0 Peroxin 13, N-terminal region AP2 PF00847.20 KOO32264.1 - 0.0008 19.6 6.6 0.3 11.4 0.1 4.3 3 1 1 4 4 4 3 AP2 domain UPF0061 PF02696.14 KOO32265.1 - 1.3e-86 291.3 0.0 1.7e-86 290.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family ABC2_membrane_3 PF12698.7 KOO32266.1 - 5.9e-22 78.2 26.6 1e-20 74.2 26.6 2.1 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 KOO32266.1 - 2.7e-06 26.9 18.6 2.7e-06 26.9 18.6 1.9 1 1 0 1 1 1 1 ABC-2 type transporter UPF0258 PF06789.12 KOO32266.1 - 0.62 10.2 1.4 1.1 9.3 1.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) ABC2_membrane_2 PF12679.7 KOO32266.1 - 0.7 9.1 22.2 3.6 6.8 21.7 2.1 1 1 1 2 2 2 0 ABC-2 family transporter protein Pro_isomerase PF00160.21 KOO32267.1 - 4.7e-08 33.5 0.0 1.2e-07 32.1 0.0 1.5 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD LRR_6 PF13516.6 KOO32268.1 - 0.006 16.5 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 Leucine Rich repeat DUF523 PF04463.12 KOO32269.1 - 0.033 14.2 1.8 3.6 7.6 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF523) TRAPPC-Trs85 PF12739.7 KOO32269.1 - 0.14 11.1 0.2 0.37 9.7 0.2 1.7 1 1 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Meleagrin PF08189.11 KOO32269.1 - 0.58 9.9 6.0 6.9 6.5 0.1 3.0 3 0 0 3 3 3 0 Meleagrin/Cygnin family SpoU_methylase PF00588.19 KOO32270.1 - 7.4e-15 55.4 0.0 1.5e-06 28.5 0.0 2.7 2 1 0 3 3 3 2 SpoU rRNA Methylase family DUF952 PF06108.12 KOO32271.1 - 1.6e-13 50.4 0.0 2.8e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF952) Cupin_3 PF05899.12 KOO32271.1 - 4.4e-05 23.1 0.1 9.9e-05 22.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) AraC_binding_2 PF14525.6 KOO32271.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 AraC-binding-like domain Cupin_2 PF07883.11 KOO32271.1 - 0.18 11.5 0.0 0.18 11.5 0.0 1.6 2 0 0 2 2 2 0 Cupin domain zf-Tim10_DDP PF02953.15 KOO32272.1 - 1.3e-20 72.8 5.8 1.5e-20 72.6 5.8 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger SPC22 PF04573.12 KOO32272.1 - 0.024 14.1 0.0 0.026 14.0 0.0 1.0 1 0 0 1 1 1 0 Signal peptidase subunit Galactosyl_T PF01762.21 KOO32273.1 - 0.00068 19.5 0.0 0.6 9.9 0.0 2.5 2 1 0 2 2 2 2 Galactosyltransferase Fringe PF02434.16 KOO32273.1 - 0.21 11.0 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 Fringe-like Ank_4 PF13637.6 KOO32274.1 - 4.4e-25 87.7 9.9 1.2e-05 25.8 0.0 6.2 3 3 3 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO32274.1 - 5.5e-24 84.6 10.3 5.3e-07 30.1 0.0 4.0 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 KOO32274.1 - 1.4e-20 72.8 18.3 1.1e-05 25.6 0.3 6.8 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 KOO32274.1 - 5.7e-18 63.2 10.1 5.4e-05 23.3 0.0 7.9 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 KOO32274.1 - 4.5e-13 49.1 10.7 0.00014 22.1 0.2 5.3 3 2 3 6 6 6 4 Ankyrin repeats (many copies) YjbE PF11106.8 KOO32274.1 - 0.51 10.6 9.5 2.6 8.3 0.3 2.8 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE Methyltransf_11 PF08241.12 KOO32277.1 - 6.3e-12 46.0 0.0 1.3e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO32277.1 - 5.1e-08 33.5 0.0 1.9e-07 31.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO32277.1 - 2.6e-05 24.1 0.0 3.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO32277.1 - 7.6e-05 23.4 0.0 0.00019 22.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO32277.1 - 8.1e-05 22.5 0.0 0.00011 22.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO32277.1 - 0.0006 19.2 0.0 0.00081 18.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 KOO32277.1 - 0.027 13.0 0.0 0.037 12.6 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ion_trans PF00520.31 KOO32278.1 - 4e-13 49.2 2.5 5.8e-13 48.6 2.5 1.2 1 0 0 1 1 1 1 Ion transport protein WW PF00397.26 KOO32279.1 - 7e-11 42.0 0.3 1.2e-10 41.3 0.3 1.4 1 0 0 1 1 1 1 WW domain PTPA PF03095.15 KOO32281.1 - 4.5e-108 361.3 0.0 1.1e-107 359.9 0.0 1.6 1 1 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein RCC1_2 PF13540.6 KOO32282.1 - 3.5e-21 74.4 32.8 3.4e-05 23.5 0.4 6.6 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 KOO32282.1 - 2.2e-17 63.4 33.0 0.0011 19.5 0.3 6.8 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat zf-CCHH PF10283.9 KOO32282.1 - 0.019 14.9 0.7 44 4.2 0.0 4.1 3 0 0 3 3 3 0 PBZ domain DUF5353 PF17304.2 KOO32282.1 - 2.1 8.1 4.3 4.4 7.1 0.0 3.3 4 0 0 4 4 4 0 Family of unknown function (DUF5353) Pkinase PF00069.25 KOO32283.1 - 5.8e-69 232.4 0.0 7e-69 232.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32283.1 - 1.4e-35 122.8 0.0 1.9e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO32283.1 - 6.3e-07 29.0 0.0 7.1e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like cNMP_binding PF00027.29 KOO32283.1 - 0.0026 17.8 0.0 0.0068 16.4 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain U-box PF04564.15 KOO32284.1 - 6.1e-13 48.7 0.0 9.9e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO32284.1 - 8.6e-13 48.5 1.5 4.5e-05 24.0 0.5 3.5 3 0 0 3 3 3 3 Sel1 repeat zf-NOSIP PF15906.5 KOO32284.1 - 0.00095 19.3 0.0 0.0025 17.9 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO32284.1 - 0.0015 18.3 0.2 0.0051 16.6 0.0 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit MKLP1_Arf_bdg PF16540.5 KOO32284.1 - 0.06 13.4 0.0 0.093 12.8 0.0 1.4 1 0 0 1 1 1 0 Arf6-interacting domain of mitotic kinesin-like protein 1 DIOX_N PF14226.6 KOO32285.1 - 3.8e-21 76.0 0.0 6e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 KOO32285.1 - 1.3e-12 48.0 0.0 2.2e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CG-1 PF03859.16 KOO32286.1 - 1.3e-17 63.7 0.1 1.6e-17 63.4 0.1 1.1 1 0 0 1 1 1 1 CG-1 domain DUF1298 PF06974.13 KOO32287.1 - 4.3e-21 75.4 0.0 7.9e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) WES_acyltransf PF03007.16 KOO32287.1 - 4e-05 23.5 0.5 0.00062 19.6 0.0 2.0 2 0 0 2 2 2 1 Wax ester synthase-like Acyl-CoA acyltransferase domain Condensation PF00668.20 KOO32287.1 - 0.0023 16.7 0.1 0.065 11.9 0.0 2.3 3 0 0 3 3 3 1 Condensation domain LRR_6 PF13516.6 KOO32288.1 - 0.00067 19.5 0.4 0.069 13.2 0.0 2.6 2 0 0 2 2 2 1 Leucine Rich repeat NACHT PF05729.12 KOO32288.1 - 0.0067 16.4 2.8 0.017 15.0 2.5 1.9 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 KOO32288.1 - 0.0078 15.8 0.0 0.029 13.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO32288.1 - 0.012 16.0 0.3 0.012 16.0 0.3 3.3 2 1 0 2 2 2 0 AAA ATPase domain WXG100 PF06013.12 KOO32288.1 - 0.013 15.7 0.1 0.056 13.7 0.1 2.1 1 0 0 1 1 1 0 Proteins of 100 residues with WXG AAA_22 PF13401.6 KOO32288.1 - 0.014 15.6 0.0 0.048 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.6 KOO32288.1 - 0.22 10.8 6.9 0.37 10.1 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CorA PF01544.18 KOO32288.1 - 4.6 6.5 6.6 8.3 5.6 6.6 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein His_Phos_1 PF00300.22 KOO32289.1 - 3.8e-17 62.6 0.4 1.8e-12 47.4 0.2 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Sel1 PF08238.12 KOO32290.1 - 4.5e-12 46.2 12.8 0.00011 22.8 1.5 4.0 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.15 KOO32290.1 - 1.7e-11 44.1 0.0 2.9e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO32290.1 - 0.0029 17.4 0.0 0.006 16.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO32290.1 - 0.0079 16.3 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 KOO32291.1 - 4.3e-12 46.0 0.0 8e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO32291.1 - 9.8e-11 42.0 9.5 4.5e-06 27.2 1.4 3.7 3 0 0 3 3 3 2 Sel1 repeat zf-NOSIP PF15906.5 KOO32291.1 - 0.00046 20.3 0.0 0.0009 19.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO32291.1 - 0.0009 19.0 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit ADP_ribosyl_GH PF03747.14 KOO32291.1 - 0.0043 16.8 0.7 0.0066 16.2 0.7 1.3 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase DUF469 PF04320.14 KOO32291.1 - 0.047 14.5 0.0 2.3 9.1 0.0 2.6 2 0 0 2 2 2 0 Protein with unknown function (DUF469) Sigma70_r3 PF04539.16 KOO32291.1 - 0.054 13.6 0.1 0.14 12.3 0.1 1.7 1 0 0 1 1 1 0 Sigma-70 region 3 TPR_6 PF13174.6 KOO32291.1 - 0.52 11.1 3.0 4 8.3 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.12 KOO32292.1 - 1.3e-11 44.7 4.9 1.6e-05 25.4 0.8 3.4 3 0 0 3 3 3 3 Sel1 repeat CZB PF13682.6 KOO32292.1 - 0.0037 17.7 0.8 0.0076 16.7 0.8 1.5 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain zf-Nse PF11789.8 KOO32292.1 - 0.089 12.6 0.3 2.8 7.8 0.0 2.8 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 KOO32293.1 - 2.1e-12 47.0 0.0 4.7e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO32293.1 - 4.7e-08 33.4 22.6 1.1e-06 29.1 1.7 3.7 4 0 0 4 4 4 2 Sel1 repeat zf-NOSIP PF15906.5 KOO32293.1 - 0.00051 20.1 0.0 0.001 19.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO32293.1 - 0.00094 18.9 0.3 0.0022 17.8 0.0 1.7 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Sigma70_r3 PF04539.16 KOO32293.1 - 0.06 13.5 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Sigma-70 region 3 Nucleotid_trans PF03407.16 KOO32294.1 - 1.5e-17 64.3 0.0 1.6e-08 34.8 0.1 2.3 2 0 0 2 2 2 2 Nucleotide-diphospho-sugar transferase LRR_8 PF13855.6 KOO32295.1 - 1.9e-18 66.0 11.6 2.9e-09 36.6 0.6 4.2 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 KOO32295.1 - 9.2e-16 57.7 11.1 5.6e-05 23.4 0.4 5.0 1 1 6 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO32295.1 - 5.3e-07 29.3 1.9 4.3e-05 23.1 0.3 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 KOO32295.1 - 0.00027 21.1 7.7 15 6.7 2.7 6.2 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 KOO32295.1 - 0.0099 15.9 9.2 2.8 8.2 0.0 4.8 6 0 0 6 6 6 2 Leucine Rich repeat Pkinase_Tyr PF07714.17 KOO32295.1 - 0.085 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.25 KOO32295.1 - 0.1 11.9 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain 6PGD PF00393.19 KOO32296.1 - 1.7e-62 211.4 0.0 2.2e-62 211.1 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KOO32296.1 - 1.5e-40 139.0 0.2 2.3e-40 138.4 0.2 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 KOO32296.1 - 0.00052 20.0 0.0 0.00087 19.2 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_11 PF14833.6 KOO32296.1 - 0.026 14.8 0.2 0.058 13.6 0.2 1.6 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_Gly3P_dh_N PF01210.23 KOO32296.1 - 0.14 12.2 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus IlvN PF07991.12 KOO32296.1 - 0.21 11.1 0.8 1.2 8.7 0.0 2.4 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain EF-hand_7 PF13499.6 KOO32297.1 - 1.5e-08 35.0 0.2 3.2e-08 33.9 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO32297.1 - 3.3e-06 26.4 2.2 0.00065 19.1 0.5 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO32297.1 - 3.6e-06 26.1 2.0 0.00015 21.1 0.6 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO32297.1 - 5e-06 26.0 0.8 0.00011 21.8 0.3 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 KOO32297.1 - 0.0013 18.5 2.5 0.0054 16.6 0.6 2.3 1 1 1 2 2 2 2 EF-hand domain pair FeThRed_B PF02943.15 KOO32298.1 - 2.1e-38 130.6 2.5 3.1e-38 130.0 2.5 1.2 1 0 0 1 1 1 1 Ferredoxin thioredoxin reductase catalytic beta chain DUF3008 PF11450.8 KOO32298.1 - 0.096 12.9 1.0 0.16 12.1 1.0 1.3 1 0 0 1 1 1 0 Protein of unknwon function (DUF3008) GRIP PF01465.20 KOO32299.1 - 0.00062 19.6 0.0 0.0018 18.1 0.0 1.9 1 0 0 1 1 1 1 GRIP domain EF-hand_1 PF00036.32 KOO32301.1 - 3e-26 89.0 9.0 1.9e-08 33.2 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO32301.1 - 8.3e-26 90.2 8.0 2.9e-14 53.3 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO32301.1 - 3.5e-22 76.4 4.3 6e-09 35.1 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO32301.1 - 1.2e-19 69.9 16.2 1e-08 34.9 0.2 3.8 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO32301.1 - 3.7e-14 52.8 0.4 9.3e-06 25.9 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO32301.1 - 1.9e-07 30.3 13.7 7.3e-05 22.1 0.4 4.1 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.7 KOO32301.1 - 2.4e-06 27.4 2.5 0.085 12.8 0.1 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SUB1_ProdP9 PF18213.1 KOO32301.1 - 0.0016 18.3 0.2 0.0034 17.2 0.2 1.5 1 0 0 1 1 1 1 SUB1 protease Prodomain ProdP9 DUF2992 PF11208.8 KOO32301.1 - 0.011 16.0 0.1 0.016 15.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) MgtE_N PF03448.17 KOO32301.1 - 0.019 15.6 1.2 0.029 15.0 0.2 1.8 2 1 0 2 2 2 0 MgtE intracellular N domain Caleosin PF05042.13 KOO32301.1 - 0.027 14.4 0.4 20 5.0 0.0 3.6 1 1 3 4 4 4 0 Caleosin related protein EF-hand_11 PF08976.11 KOO32301.1 - 0.032 15.1 0.3 3.3 8.6 0.1 2.2 1 1 1 2 2 2 0 EF-hand domain SurA_N_3 PF13624.6 KOO32301.1 - 0.045 13.5 0.2 0.51 10.1 0.0 2.1 1 1 1 2 2 2 0 SurA N-terminal domain EF-hand_14 PF17959.1 KOO32301.1 - 0.047 14.0 0.4 1.3 9.5 0.1 2.5 2 1 0 2 2 2 0 EF-hand domain Toprim PF01751.22 KOO32301.1 - 0.047 13.9 0.0 0.078 13.2 0.0 1.3 1 0 0 1 1 1 0 Toprim domain DUF3008 PF11450.8 KOO32301.1 - 1.9 8.7 0.0 1.9 8.7 0.0 3.0 3 0 0 3 3 2 0 Protein of unknwon function (DUF3008) Epimerase PF01370.21 KOO32302.1 - 8.9e-17 61.4 0.0 1.6e-14 54.0 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO32302.1 - 7.7e-14 51.8 0.0 8.6e-08 31.9 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 KOO32302.1 - 5.8e-12 45.9 0.0 1e-11 45.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 KOO32302.1 - 0.00014 21.0 0.0 0.00059 19.0 0.0 1.8 2 0 0 2 2 2 1 RmlD substrate binding domain DUF4848 PF16140.5 KOO32302.1 - 0.0082 15.7 0.0 0.018 14.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4848) adh_short PF00106.25 KOO32302.1 - 0.092 12.2 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase TylF PF05711.11 KOO32303.1 - 1.2e-21 77.2 0.0 1.7e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 KOO32303.1 - 0.0067 17.4 0.0 0.0088 17.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_6 PF13405.6 KOO32304.1 - 8e-30 100.2 12.2 2.2e-06 27.1 0.1 6.8 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.32 KOO32304.1 - 1.6e-27 92.9 18.8 4.5e-05 22.7 0.3 6.8 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO32304.1 - 6.2e-25 87.5 12.3 3.2e-08 33.9 0.5 4.9 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO32304.1 - 9.1e-18 62.9 18.1 0.00082 18.8 0.4 6.5 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO32304.1 - 6.1e-14 51.6 12.9 0.00085 19.1 0.9 5.9 4 1 1 5 5 5 5 EF-hand domain pair LCE6A PF15858.5 KOO32304.1 - 0.69 10.7 3.3 2.1 9.2 3.3 1.8 1 0 0 1 1 1 0 Late cornified envelope protein 6A family EF-hand_4 PF12763.7 KOO32304.1 - 0.81 9.7 4.5 3.9 7.5 0.1 3.4 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand DUF1116 PF06545.11 KOO32305.1 - 9e-71 237.7 0.0 1.4e-70 237.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1116) Isochorismatase PF00857.20 KOO32305.1 - 3e-37 128.5 0.0 5.9e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family Catalase_C PF18011.1 KOO32305.1 - 0.14 11.8 0.1 0.3 10.7 0.1 1.4 1 0 0 1 1 1 0 C-terminal domain found in long catalases NAD_binding_10 PF13460.6 KOO32307.1 - 6.5e-36 123.9 0.1 9.6e-36 123.4 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO32307.1 - 3.4e-08 33.3 1.2 0.01 15.4 0.6 3.1 3 1 0 3 3 3 2 NmrA-like family Epimerase PF01370.21 KOO32307.1 - 5.8e-07 29.2 0.0 0.0001 21.9 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 KOO32307.1 - 3.5e-06 27.1 0.3 5.6e-06 26.5 0.3 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.19 KOO32307.1 - 6.1e-06 25.5 0.0 0.046 12.7 0.1 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.20 KOO32307.1 - 0.00033 20.7 0.2 0.00058 19.9 0.2 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 KOO32307.1 - 0.00047 20.6 0.2 0.00085 19.7 0.2 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 KOO32307.1 - 0.00056 19.1 0.0 0.93 8.6 0.0 2.2 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 KOO32307.1 - 0.017 15.4 0.5 0.029 14.6 0.5 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Ldh_1_N PF00056.23 KOO32307.1 - 0.039 14.1 0.2 0.51 10.4 0.3 2.1 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain GARS_N PF02844.15 KOO32307.1 - 0.097 13.5 0.3 0.28 12.0 0.1 1.9 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, N domain CoA_binding PF02629.19 KOO32307.1 - 0.28 11.9 0.1 0.28 11.9 0.1 2.2 3 0 0 3 3 3 0 CoA binding domain eIF-5a PF01287.20 KOO32308.1 - 7.1e-18 64.5 0.0 1.1e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 KOO32308.1 - 0.00026 21.0 0.2 0.00026 21.0 0.2 1.7 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain Rcd1 PF04078.13 KOO32309.1 - 8.9e-129 428.3 0.1 1e-128 428.1 0.1 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Ank_2 PF12796.7 KOO32310.1 - 1.9e-43 146.9 16.1 6.2e-10 39.5 0.5 5.8 2 1 3 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO32310.1 - 1.1e-31 108.8 12.8 1.2e-07 32.2 0.5 6.2 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Pkinase PF00069.25 KOO32310.1 - 9.5e-28 97.3 0.0 2.2e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.6 KOO32310.1 - 8.8e-27 92.8 16.3 2.9e-07 30.6 0.2 7.1 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 KOO32310.1 - 6.8e-22 78.0 0.0 1.4e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 KOO32310.1 - 2.2e-19 69.0 31.5 0.00064 20.1 0.7 8.8 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 KOO32310.1 - 2.7e-18 64.2 16.6 0.0012 19.1 0.1 9.1 9 0 0 9 9 9 5 Ankyrin repeat DUF5323 PF17257.2 KOO32310.1 - 3.6e-07 29.9 4.7 8.4e-07 28.8 4.7 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5323) APH PF01636.23 KOO32310.1 - 1.8 8.4 11.8 0.33 10.8 5.6 3.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Phospholip_A2_2 PF05826.12 KOO32310.1 - 3.2 8.1 5.2 14 6.0 0.1 2.9 2 1 1 3 3 3 0 Phospholipase A2 DUF3446 PF11928.8 KOO32310.1 - 4.7 7.6 8.0 19 5.6 0.5 3.0 2 0 0 2 2 2 0 Early growth response N-terminal domain C2 PF00168.30 KOO32312.1 - 4e-61 203.7 0.0 6.7e-13 48.8 0.0 6.8 6 0 0 6 6 6 6 C2 domain FerI PF08151.12 KOO32312.1 - 0.00064 19.8 0.0 0.002 18.2 0.0 1.9 1 0 0 1 1 1 1 FerI (NUC094) domain BBS2_C PF14782.6 KOO32312.1 - 1.4 7.6 3.9 2.5 6.7 3.9 1.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF1764 PF08576.10 KOO32312.1 - 3.2 8.7 4.5 1.9 9.5 0.1 2.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Pkinase PF00069.25 KOO32313.1 - 4.4e-64 216.4 0.0 6.8e-64 215.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32313.1 - 1.3e-32 113.2 0.0 2e-32 112.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 KOO32313.1 - 2.1e-21 76.2 12.2 9.7e-08 32.4 0.1 3.2 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO32313.1 - 2.4e-15 56.1 9.1 7.1e-05 22.6 0.1 4.6 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO32313.1 - 2.6e-15 54.9 3.8 2.2e-05 24.0 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO32313.1 - 5e-12 44.5 4.9 0.00012 21.4 0.1 4.2 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 KOO32313.1 - 6.7e-12 44.3 0.3 1.1e-05 24.7 0.0 2.9 2 0 0 2 2 2 2 EF hand Pkinase_fungal PF17667.1 KOO32313.1 - 0.00071 18.5 0.1 0.0015 17.4 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase EF-hand_11 PF08976.11 KOO32313.1 - 0.0023 18.8 0.0 0.099 13.5 0.0 2.7 1 1 1 2 2 2 1 EF-hand domain Kinase-like PF14531.6 KOO32313.1 - 0.0058 16.0 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like NADPH_Ox PF08414.10 KOO32313.1 - 0.045 14.1 0.1 2.3 8.6 0.0 2.9 2 1 0 3 3 3 0 Respiratory burst NADPH oxidase HisKA PF00512.25 KOO32313.1 - 0.069 13.2 0.0 0.26 11.4 0.0 2.0 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain YrbL-PhoP_reg PF10707.9 KOO32313.1 - 0.14 11.7 0.1 0.25 10.8 0.1 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL EF-hand_9 PF14658.6 KOO32313.1 - 0.17 12.2 0.2 1.9 8.9 0.0 2.8 3 0 0 3 3 2 0 EF-hand domain Chloroa_b-bind PF00504.21 KOO32314.1 - 1.2e-31 110.4 0.5 1.5e-31 110.1 0.5 1.0 1 0 0 1 1 1 1 Chlorophyll A-B binding protein PDZ_6 PF17820.1 KOO32315.1 - 7.3e-08 32.1 0.0 2e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO32315.1 - 7.6e-06 26.2 0.0 1.9e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 PDZ domain UPF0175 PF03683.13 KOO32316.1 - 0.04 13.6 1.5 5.6 6.7 0.0 3.4 2 1 0 3 3 3 0 Uncharacterised protein family (UPF0175) WD40 PF00400.32 KOO32318.1 - 3.5e-37 125.7 37.2 3.2e-06 27.8 0.0 11.3 13 0 0 13 13 13 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO32318.1 - 1.4e-15 57.3 2.5 6.5e-05 23.2 0.2 6.4 4 3 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOO32318.1 - 1.7e-07 30.3 0.4 0.0036 16.0 0.0 3.7 3 1 1 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOO32318.1 - 1e-06 28.0 0.2 0.032 13.2 0.0 4.2 4 1 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 KOO32318.1 - 5.2e-06 26.2 2.6 0.0015 18.1 0.2 3.5 2 2 0 3 3 3 1 PQQ-like domain WD40_like PF17005.5 KOO32318.1 - 6.1e-05 22.5 0.1 0.1 11.9 0.0 3.7 3 2 1 4 4 4 2 WD40-like domain PQQ_3 PF13570.6 KOO32318.1 - 0.0061 17.0 13.9 20 5.8 0.2 8.6 9 1 0 9 9 9 0 PQQ-like domain Cytochrom_D1 PF02239.16 KOO32318.1 - 0.021 13.3 0.6 2.7 6.4 0.2 3.5 3 0 0 3 3 3 0 Cytochrome D1 heme domain Hira PF07569.11 KOO32318.1 - 0.094 12.4 0.1 97 2.6 0.0 4.0 4 1 1 5 5 5 0 TUP1-like enhancer of split Nucleotid_trans PF03407.16 KOO32319.1 - 3.1e-31 109.0 0.0 5.5e-31 108.2 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Peptidase_M18 PF02127.15 KOO32320.1 - 1.8e-144 481.7 0.0 7.3e-81 272.1 0.0 2.0 2 0 0 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 KOO32320.1 - 2.2e-06 26.9 0.0 0.00094 18.3 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Melibiase_2 PF16499.5 KOO32321.1 - 4.2e-58 196.8 0.2 5.5e-50 170.1 0.2 2.2 2 0 0 2 2 2 2 Alpha galactosidase A RVT_2 PF07727.14 KOO32321.1 - 2.8e-19 69.7 0.0 4.1e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Melibiase_C PF17801.1 KOO32321.1 - 3.2e-11 43.2 0.5 5.4e-07 29.6 0.0 2.9 3 0 0 3 3 3 2 Alpha galactosidase C-terminal beta sandwich domain ShK PF01549.24 KOO32321.1 - 2.1e-06 28.1 9.3 6.1e-06 26.7 9.3 1.9 1 0 0 1 1 1 1 ShK domain-like Melibiase PF02065.18 KOO32321.1 - 0.05 12.6 0.0 0.085 11.8 0.0 1.2 1 0 0 1 1 1 0 Melibiase PPDK_N PF01326.19 KOO32322.1 - 2.2e-29 102.8 0.0 2.1e-28 99.6 0.0 2.0 1 1 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain Response_reg PF00072.24 KOO32322.1 - 0.00061 19.9 0.0 0.0039 17.4 0.0 2.2 2 0 0 2 2 2 1 Response regulator receiver domain APH PF01636.23 KOO32323.1 - 2e-44 152.3 0.6 2e-44 152.3 0.6 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family adh_short PF00106.25 KOO32323.1 - 3.3e-28 98.5 0.1 5.2e-28 97.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO32323.1 - 6.7e-21 74.9 0.1 1.5e-20 73.8 0.1 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO32323.1 - 2.6e-09 37.2 0.1 4.8e-09 36.4 0.1 1.4 1 0 0 1 1 1 1 KR domain EcKinase PF02958.20 KOO32323.1 - 2.5e-06 27.0 0.0 3.9e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 KOO32323.1 - 0.00043 19.3 0.0 0.00064 18.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 KOO32323.1 - 0.025 14.2 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 KOO32323.1 - 0.036 13.2 0.0 0.54 9.4 0.0 2.0 2 0 0 2 2 2 0 Fructosamine kinase RIO1 PF01163.22 KOO32323.1 - 0.066 12.8 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 RIO1 family Phage_TAC_7 PF10109.9 KOO32323.1 - 0.093 12.8 0.0 0.32 11.1 0.0 1.9 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, E, or 41 or 14 LRR_8 PF13855.6 KOO32324.1 - 5.7e-14 51.6 4.6 9e-05 22.2 0.0 3.5 3 0 0 3 3 3 3 Leucine rich repeat Zeta_toxin PF06414.12 KOO32324.1 - 1.8e-12 47.0 5.2 3.5e-08 33.0 0.0 3.2 4 0 0 4 4 4 2 Zeta toxin LRR_4 PF12799.7 KOO32324.1 - 2.1e-11 43.8 9.3 0.00065 20.0 2.1 4.6 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) AAA_33 PF13671.6 KOO32324.1 - 2.9e-06 27.5 0.2 0.00011 22.4 0.0 3.3 3 1 0 3 3 3 1 AAA domain LRR_1 PF00560.33 KOO32324.1 - 9.3e-06 25.5 7.4 24 6.0 0.6 6.4 6 0 0 6 6 6 0 Leucine Rich Repeat AAA PF00004.29 KOO32324.1 - 0.0037 17.7 0.1 0.028 14.8 0.0 2.6 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KOO32324.1 - 0.0059 16.6 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain ABC_tran PF00005.27 KOO32324.1 - 0.0064 17.0 1.0 0.05 14.1 0.0 2.8 3 0 0 3 3 3 1 ABC transporter zf-RING_9 PF13901.6 KOO32324.1 - 0.0068 16.4 3.8 0.0068 16.4 3.8 2.3 1 1 0 2 2 2 1 Putative zinc-RING and/or ribbon AAA_15 PF13175.6 KOO32324.1 - 0.011 15.5 4.4 0.83 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KOO32324.1 - 0.014 15.6 0.2 0.16 12.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 KOO32324.1 - 0.035 14.5 5.6 0.26 11.7 0.0 3.7 3 0 0 3 3 3 0 AAA ATPase domain AAA_18 PF13238.6 KOO32324.1 - 0.035 14.7 0.0 0.25 11.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Leucyl-specific PF14795.6 KOO32324.1 - 0.1 12.7 1.8 0.17 11.9 0.0 2.4 2 0 0 2 2 1 0 Leucine-tRNA synthetase-specific domain RNA_helicase PF00910.22 KOO32324.1 - 0.2 12.0 0.0 0.54 10.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 KOO32324.1 - 0.33 10.8 4.7 1.7 8.5 0.0 2.7 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea LRR_6 PF13516.6 KOO32324.1 - 0.84 9.9 3.9 93 3.5 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich repeat Folliculin PF11704.8 KOO32324.1 - 2.1 8.2 0.0 2.1 8.2 0.0 3.0 3 0 0 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport FtsX_ECD PF18075.1 KOO32324.1 - 2.3 8.9 5.6 1.7 9.4 2.3 2.5 2 0 0 2 2 1 0 FtsX extracellular domain Aldo_ket_red PF00248.21 KOO32325.1 - 3.1e-23 82.4 0.0 3.6e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Ank_2 PF12796.7 KOO32327.1 - 3.9e-31 107.5 2.4 1.8e-09 38.1 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO32327.1 - 7.7e-22 77.4 0.8 2.6e-07 31.0 0.0 4.2 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO32327.1 - 2.2e-21 75.6 2.7 0.00029 21.0 0.0 5.8 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 KOO32327.1 - 5.1e-18 64.6 6.5 0.00041 20.7 0.0 5.9 3 1 3 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 KOO32327.1 - 3.8e-17 60.6 0.2 0.0069 16.8 0.0 6.0 6 0 0 6 6 6 4 Ankyrin repeat I_LWEQ PF01608.17 KOO32327.1 - 0.011 16.0 4.5 0.29 11.4 0.1 2.3 1 1 1 2 2 2 0 I/LWEQ domain ING PF12998.7 KOO32328.1 - 0.048 14.2 0.2 0.12 13.0 0.2 1.6 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding DUF3340 PF11818.8 KOO32328.1 - 0.085 13.0 6.9 5.9 7.0 2.3 3.0 1 1 1 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) Stomagen PF16851.5 KOO32328.1 - 0.41 10.7 4.8 40 4.3 0.3 3.5 3 0 0 3 3 3 0 Stomagen Phage_Mu_Gam PF07352.12 KOO32328.1 - 5.7 6.8 14.6 16 5.3 4.7 3.4 1 1 3 4 4 4 0 Bacteriophage Mu Gam like protein Filamin PF00630.19 KOO32329.1 - 1.4e-24 86.9 0.0 4.2e-06 27.5 0.0 5.0 4 1 1 5 5 5 4 Filamin/ABP280 repeat CAP_GLY PF01302.25 KOO32329.1 - 3.3e-16 59.1 1.5 8.4e-16 57.7 1.5 1.8 1 0 0 1 1 1 1 CAP-Gly domain Y_Y_Y PF07495.13 KOO32329.1 - 0.031 14.2 0.0 5.7 7.0 0.0 2.4 2 0 0 2 2 2 0 Y_Y_Y domain Invasin_D3 PF09134.10 KOO32329.1 - 0.071 13.4 0.0 0.86 10.0 0.0 2.3 2 0 0 2 2 2 0 Invasin, domain 3 Defensin_4 PF07936.12 KOO32329.1 - 3.7 7.5 5.3 0.76 9.7 0.8 2.0 2 0 0 2 2 2 0 Potassium-channel blocking toxin Acetyltransf_1 PF00583.25 KOO32333.1 - 2.3e-13 50.4 0.0 2.6e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO32333.1 - 4.2e-10 39.9 0.0 6.3e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO32333.1 - 6.4e-10 39.1 0.0 3.8e-09 36.6 0.0 1.9 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO32333.1 - 1e-07 31.8 0.0 2.1e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 KOO32333.1 - 4.2e-07 30.1 0.0 4.9e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain zf-Nse PF11789.8 KOO32334.1 - 0.00034 20.4 2.7 0.0014 18.4 2.7 1.9 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit mRNA_cap_enzyme PF01331.19 KOO32336.1 - 0.043 13.6 0.0 0.14 12.0 0.0 1.8 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain F1F0-ATPsyn_F PF10791.9 KOO32337.1 - 0.004 17.6 0.1 0.0088 16.5 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi Peptidase_M14 PF00246.24 KOO32338.1 - 1.4e-15 57.8 0.0 4.4e-15 56.3 0.0 1.8 2 0 0 2 2 2 1 Zinc carboxypeptidase LELP1 PF15042.6 KOO32338.1 - 0.0048 17.3 1.0 0.0099 16.3 0.1 1.8 2 1 0 2 2 2 1 Late cornified envelope-like proline-rich protein 1 Mg_trans_NIPA PF05653.14 KOO32339.1 - 1.7e-14 53.6 10.8 2.5e-14 53.1 10.8 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA Amidohydro_2 PF04909.14 KOO32340.1 - 1.1e-08 35.2 0.9 1.1e-07 32.0 0.8 2.6 2 1 0 2 2 2 1 Amidohydrolase RhoGEF PF00621.20 KOO32342.1 - 1.9e-26 93.4 0.0 3.2e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain IlvGEDA_leader PF08046.11 KOO32345.1 - 0.66 9.5 4.7 2.3 7.7 1.3 2.2 2 0 0 2 2 2 0 IlvGEDA operon leader peptide GTP_cyclohydro2 PF00925.20 KOO32346.1 - 1.9e-58 196.7 0.0 2.8e-58 196.1 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II Harakiri PF15196.6 KOO32347.1 - 0.071 13.6 3.5 7 7.2 0.6 3.1 1 1 1 2 2 2 0 Activator of apoptosis harakiri PH PF00169.29 KOO32351.1 - 3.5e-05 24.2 0.0 7.6e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 KOO32351.1 - 0.072 13.4 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain Peptidase_S24 PF00717.23 KOO32352.1 - 2.4e-11 43.4 0.2 4e-11 42.7 0.2 1.3 1 0 0 1 1 1 1 Peptidase S24-like DSPc PF00782.20 KOO32353.1 - 1.1e-11 44.7 0.0 1.9e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 KOO32353.1 - 0.016 15.5 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase PF00102.27 KOO32353.1 - 0.02 14.5 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Suppressor_APC PF11414.8 KOO32354.1 - 0.13 12.4 0.5 0.46 10.6 0.1 2.1 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein UTP15_C PF09384.10 KOO32355.1 - 1.1e-41 142.0 0.0 1.6e-41 141.4 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 KOO32355.1 - 1.1e-18 67.2 2.8 0.00055 20.7 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO32355.1 - 5.4e-05 23.4 0.0 0.0051 17.1 0.0 3.3 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleotid_trans PF03407.16 KOO32355.1 - 0.024 14.6 0.0 0.038 14.0 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Rotamase PF00639.21 KOO32356.1 - 5.6e-18 65.7 0.9 4.9e-17 62.7 0.0 2.4 3 0 0 3 3 3 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOO32356.1 - 4.5e-16 59.4 0.0 1.2e-15 58.1 0.0 1.7 1 1 0 1 1 1 1 PPIC-type PPIASE domain PUB PF09409.10 KOO32356.1 - 1.4e-13 50.5 0.0 4.1e-13 49.1 0.0 1.7 2 0 0 2 2 2 1 PUB domain ECM1 PF05782.11 KOO32356.1 - 0.018 14.0 0.0 0.023 13.7 0.0 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) Kri1 PF05178.12 KOO32356.1 - 0.036 14.6 3.8 0.14 12.7 2.5 2.4 3 0 0 3 3 3 0 KRI1-like family UPF0561 PF10573.9 KOO32356.1 - 0.11 12.6 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 SF-assemblin PF06705.11 KOO32357.1 - 7.1e-05 22.3 13.4 0.00085 18.7 13.1 2.6 1 1 1 2 2 2 1 SF-assemblin/beta giardin LCIB_C_CA PF18599.1 KOO32357.1 - 0.58 9.4 2.5 6.3 6.0 0.2 2.1 1 1 1 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases DUF1178 PF06676.11 KOO32357.1 - 1.3 9.4 10.2 3.7 7.9 10.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1178) ECH_1 PF00378.20 KOO32359.1 - 3.3e-39 134.7 0.1 3.6e-39 134.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOO32359.1 - 4.1e-27 95.6 2.7 4.9e-22 78.9 0.8 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase LRR_6 PF13516.6 KOO32361.1 - 7.5e-21 72.4 50.6 0.00037 20.3 0.4 15.8 17 0 0 17 17 17 7 Leucine Rich repeat LRR_4 PF12799.7 KOO32361.1 - 1.3e-10 41.4 13.1 1.6 9.3 0.0 8.2 7 2 0 8 8 8 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO32361.1 - 1.2e-09 37.4 0.9 34 5.5 0.2 9.3 10 0 0 10 10 10 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO32361.1 - 0.00038 20.2 16.2 0.91 9.3 0.1 7.9 7 4 0 7 7 7 2 Leucine rich repeat FIBP PF05427.11 KOO32361.1 - 0.00076 18.9 0.1 11 5.2 0.0 3.1 3 0 0 3 3 3 3 Acidic fibroblast growth factor binding (FIBP) Metal_CEHH PF14455.6 KOO32361.1 - 0.0015 18.1 0.1 8.6 5.9 0.0 4.4 3 2 2 5 5 5 1 Predicted metal binding domain Sec23_BS PF08033.12 KOO32361.1 - 0.01 16.6 0.1 11 6.9 0.0 4.5 4 1 1 5 5 5 0 Sec23/Sec24 beta-sandwich domain SpoU_sub_bind PF08032.12 KOO32361.1 - 0.15 12.4 1.9 1.6e+02 2.7 0.0 4.7 5 0 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding Costars PF14705.6 KOO32363.1 - 2e-13 50.3 0.0 3e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Costars Mg-por_mtran_C PF07109.11 KOO32364.1 - 1.7e-33 114.9 0.0 2.9e-33 114.1 0.0 1.4 1 0 0 1 1 1 1 Magnesium-protoporphyrin IX methyltransferase C-terminus Methyltransf_25 PF13649.6 KOO32364.1 - 2.8e-15 56.8 0.1 6.5e-15 55.6 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO32364.1 - 2e-12 47.1 0.0 2.9e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO32364.1 - 3.7e-11 43.6 0.0 6.8e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO32364.1 - 1.5e-10 41.1 0.0 2.2e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO32364.1 - 2e-10 41.2 0.2 7.8e-10 39.3 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 KOO32364.1 - 1.2e-08 34.6 0.0 2.7e-08 33.4 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 KOO32364.1 - 4.2e-07 29.7 0.1 7.3e-07 28.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 KOO32364.1 - 2.8e-06 27.4 0.1 4.5e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KOO32364.1 - 9.3e-06 25.6 0.0 1.7e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO32364.1 - 0.00012 21.5 0.2 0.00022 20.6 0.1 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family tRNA_U5-meth_tr PF05958.11 KOO32364.1 - 0.00037 19.6 0.0 0.0045 16.0 0.0 2.0 1 1 1 2 2 2 1 tRNA (Uracil-5-)-methyltransferase PrmA PF06325.13 KOO32364.1 - 0.00048 19.6 0.1 0.00094 18.6 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 KOO32364.1 - 0.00049 19.6 0.0 0.00062 19.2 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB UPF0020 PF01170.18 KOO32364.1 - 0.0018 18.0 0.3 0.0068 16.1 0.3 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 CheR PF01739.18 KOO32364.1 - 0.0063 16.0 0.3 2.2 7.7 0.0 2.2 1 1 1 2 2 2 2 CheR methyltransferase, SAM binding domain Mur_ligase PF01225.25 KOO32364.1 - 0.033 14.5 0.0 0.07 13.5 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, catalytic domain NodS PF05401.11 KOO32364.1 - 0.036 13.7 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) DREV PF05219.12 KOO32364.1 - 0.036 13.2 0.0 0.048 12.8 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Pro_dh PF01619.18 KOO32365.1 - 8.5e-55 186.4 0.0 1e-54 186.1 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase VitK2_biosynth PF02621.14 KOO32365.1 - 0.012 15.1 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Menaquinone biosynthesis YtxH PF12732.7 KOO32365.1 - 0.077 13.5 1.8 0.17 12.5 0.2 2.3 2 0 0 2 2 2 0 YtxH-like protein PPR_3 PF13812.6 KOO32365.1 - 0.13 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Pentatricopeptide repeat domain PhoD PF09423.10 KOO32366.1 - 3e-87 292.9 6.9 4e-87 292.5 6.9 1.2 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 KOO32366.1 - 2.5e-18 66.4 0.7 3.3e-17 62.8 0.0 2.6 2 0 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain E1-E2_ATPase PF00122.20 KOO32369.1 - 3.6e-41 140.7 1.7 3.6e-41 140.7 1.7 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 KOO32369.1 - 5.6e-18 66.0 0.1 1.1e-17 65.0 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOO32369.1 - 1.2e-08 34.5 0.0 4.4e-08 32.7 0.0 2.0 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOO32369.1 - 0.004 16.9 0.4 0.01 15.6 0.2 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Radical_SAM PF04055.21 KOO32371.1 - 1.4e-07 32.1 0.0 1.8e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Collagen PF01391.18 KOO32372.1 - 0.089 12.6 6.8 0.13 12.0 6.8 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) 2OG-FeII_Oxy_3 PF13640.6 KOO32373.1 - 0.00081 20.2 0.0 0.0026 18.6 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Flavodoxin_2 PF02525.17 KOO32374.1 - 0.0042 16.8 0.1 0.0045 16.7 0.1 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold RRM_1 PF00076.22 KOO32375.1 - 0.0023 17.7 0.0 0.0045 16.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NHL PF01436.21 KOO32376.1 - 2.5e-17 61.9 1.9 7.4e-05 22.6 0.1 5.7 5 0 0 5 5 5 4 NHL repeat PDZ_2 PF13180.6 KOO32376.1 - 0.00053 20.2 0.0 0.0012 19.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO32376.1 - 0.0015 18.3 0.3 0.0048 16.7 0.3 1.9 1 1 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO32376.1 - 0.034 14.5 0.0 0.068 13.5 0.0 1.4 1 0 0 1 1 1 0 PDZ domain AbrB_C PF18277.1 KOO32376.1 - 0.081 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 AbrB C-terminal domain Kinesin PF00225.23 KOO32377.1 - 1.7e-93 313.2 0.0 2e-93 312.9 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO32377.1 - 4.8e-25 88.2 0.0 8e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.5 KOO32377.1 - 4.4e-06 26.9 0.6 0.00089 19.4 0.2 2.7 2 0 0 2 2 2 2 Kinesin-associated ABC1 PF03109.16 KOO32378.1 - 1.1e-23 83.6 0.0 2e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO32378.1 - 0.00019 21.4 2.3 0.098 12.6 0.3 2.9 2 1 0 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 KOO32378.1 - 0.026 13.9 0.0 0.061 12.7 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain zf-UBR PF02207.20 KOO32379.1 - 2.9 8.1 6.5 8.9 6.6 6.5 1.8 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) EF-hand_1 PF00036.32 KOO32380.1 - 2.8e-22 76.6 6.2 1.4e-05 24.3 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO32380.1 - 1.7e-21 76.4 7.1 6.9e-12 45.7 0.5 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO32380.1 - 1.7e-19 69.4 7.6 1.2e-08 34.6 0.0 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO32380.1 - 2e-17 61.5 5.0 0.00055 19.6 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO32380.1 - 1.9e-16 58.7 8.1 0.00043 19.6 0.0 4.6 4 0 0 4 4 4 4 EF hand zf-C2HC_2 PF13913.6 KOO32380.1 - 2.6e-12 46.3 29.5 2.8e-09 36.7 1.4 4.4 4 0 0 4 4 4 2 zinc-finger of a C2HC-type SPARC_Ca_bdg PF10591.9 KOO32380.1 - 0.00013 22.3 1.0 0.47 10.8 0.0 2.7 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO32380.1 - 0.00057 19.8 4.6 0.71 9.9 0.0 3.6 2 2 2 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO32380.1 - 0.0071 16.2 2.9 1.5 8.8 0.1 3.3 2 1 2 4 4 4 1 EF hand zf_UBZ PF18439.1 KOO32380.1 - 0.009 15.6 4.7 1.7 8.3 0.2 4.3 4 0 0 4 4 4 1 Ubiquitin-Binding Zinc Finger XAF1_C PF18608.1 KOO32380.1 - 0.021 14.3 1.1 0.59 9.7 0.1 2.7 2 0 0 2 2 2 0 XIAP-associated factor 1 C-terminal domain zf-C2H2_4 PF13894.6 KOO32380.1 - 0.07 14.0 13.6 0.38 11.7 1.3 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-ribbon_3 PF13248.6 KOO32380.1 - 0.14 11.6 11.4 0.2 11.1 0.4 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2H2 PF00096.26 KOO32380.1 - 0.28 11.7 7.7 6.9 7.3 0.3 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zinc_ribbon_2 PF13240.6 KOO32380.1 - 0.65 9.8 11.3 2.3 8.0 1.2 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 KOO32380.1 - 0.91 9.6 9.2 2.1 8.4 1.2 3.2 3 0 0 3 3 3 0 Transposase zinc-ribbon domain zinc_ribbon_9 PF14369.6 KOO32380.1 - 2.5 8.4 5.0 8.7 6.7 0.6 3.1 2 0 0 2 2 2 0 zinc-ribbon DUF35_N PF12172.8 KOO32380.1 - 6.3 6.8 13.2 4.9 7.1 0.6 3.7 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 KOO32380.1 - 7.2 6.7 9.5 11 6.1 5.3 3.1 2 1 0 2 2 2 0 Double zinc ribbon LRR_6 PF13516.6 KOO32381.1 - 6.3e-11 41.4 48.1 0.003 17.5 0.1 13.0 13 0 0 13 13 13 4 Leucine Rich repeat LRR_8 PF13855.6 KOO32381.1 - 1.6e-07 30.9 10.4 2.2 8.1 0.0 7.3 7 2 0 7 7 7 3 Leucine rich repeat LRR_1 PF00560.33 KOO32381.1 - 3e-07 30.1 9.0 18 6.4 0.1 9.5 10 0 0 10 10 10 1 Leucine Rich Repeat LRR_4 PF12799.7 KOO32381.1 - 0.00017 21.9 19.5 5.2 7.6 0.0 8.0 6 2 0 7 7 7 1 Leucine Rich repeats (2 copies) Skp1_POZ PF03931.15 KOO32381.1 - 0.038 14.2 0.0 0.08 13.1 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain DNA_pol_lambd_f PF10391.9 KOO32381.1 - 0.15 11.9 0.0 15 5.5 0.0 3.1 2 1 0 2 2 2 0 Fingers domain of DNA polymerase lambda Mito_carr PF00153.27 KOO32382.1 - 5.4e-16 58.3 0.8 4.3e-07 29.8 0.0 4.5 4 0 0 4 4 4 4 Mitochondrial carrier protein DHHC PF01529.20 KOO32383.1 - 4.9e-34 117.3 4.5 4.9e-34 117.3 4.5 1.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase EF-hand_7 PF13499.6 KOO32385.1 - 1.3e-13 51.2 1.1 5e-12 46.1 0.5 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO32385.1 - 9.7e-12 43.6 4.1 0.00058 19.2 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOO32385.1 - 8.5e-10 37.8 5.0 0.00014 21.5 0.2 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO32385.1 - 7.8e-07 28.9 1.5 3.4e-06 26.8 0.2 2.6 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO32385.1 - 1.2e-05 24.6 4.4 0.052 13.1 0.3 2.9 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 KOO32385.1 - 0.02 15.2 0.3 0.034 14.5 0.3 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region FUSC PF04632.12 KOO32385.1 - 1.3 7.4 2.5 1.6 7.2 2.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Polysacc_deac_1 PF01522.21 KOO32386.1 - 0.058 13.3 0.0 0.072 13.0 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide deacetylase MORN PF02493.20 KOO32387.1 - 2.4e-05 23.9 0.2 0.0081 16.0 0.0 2.8 2 0 0 2 2 2 2 MORN repeat C2 PF00168.30 KOO32388.1 - 9.3e-16 58.0 0.0 7.1e-15 55.2 0.0 2.2 1 1 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 KOO32388.1 - 7.8e-12 45.5 29.5 2e-07 31.3 8.6 3.2 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO32388.1 - 1.3e-11 43.1 22.7 0.006 16.0 0.6 5.3 4 1 1 5 5 5 4 EF hand EF-hand_6 PF13405.6 KOO32388.1 - 1.4e-11 43.3 21.9 0.0096 15.8 0.3 5.5 3 1 1 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO32388.1 - 6.8e-11 41.1 15.9 0.0012 18.2 0.1 4.5 4 1 0 4 4 4 3 EF hand XK-related PF09815.9 KOO32388.1 - 0.0007 18.8 3.7 0.0007 18.8 3.7 1.5 2 0 0 2 2 2 1 XK-related protein EF-hand_8 PF13833.6 KOO32388.1 - 0.0064 16.3 14.2 0.047 13.5 0.7 4.3 3 2 2 5 5 5 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO32388.1 - 0.062 13.6 8.3 0.71 10.2 1.9 2.9 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO32388.1 - 0.063 13.2 3.3 0.54 10.2 0.1 2.6 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Toprim PF01751.22 KOO32388.1 - 0.36 11.1 1.4 3.4 7.9 0.0 2.5 1 1 1 2 2 2 0 Toprim domain DUF2975 PF11188.8 KOO32388.1 - 3.9 7.4 7.8 1.2 9.0 2.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) ATG16 PF08614.11 KOO32389.1 - 0.0098 16.1 16.1 0.0098 16.1 16.1 5.8 2 1 2 5 5 5 2 Autophagy protein 16 (ATG16) Pkinase PF00069.25 KOO32390.1 - 5e-74 249.0 0.0 5.8e-74 248.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32390.1 - 8.2e-46 156.4 0.0 1e-45 156.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO32390.1 - 1.4e-07 31.1 0.0 1.9e-06 27.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KOO32390.1 - 0.017 14.5 0.1 0.027 13.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOO32390.1 - 0.06 12.9 0.1 0.13 11.8 0.1 1.6 1 1 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 KOO32390.1 - 0.073 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 FHA PF00498.26 KOO32391.1 - 1.1e-15 57.7 0.1 1.8e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO32391.1 - 1.5e-13 50.9 0.0 3.2e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain INCENP_ARK-bind PF03941.15 KOO32391.1 - 5.1e-06 26.3 0.0 1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region DUF3552 PF12072.8 KOO32391.1 - 0.00052 19.5 9.7 0.00083 18.8 2.8 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF3552) Tmemb_cc2 PF10267.9 KOO32391.1 - 0.024 13.8 0.6 0.034 13.3 0.6 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Ureidogly_lyase PF04115.12 KOO32392.1 - 1.8e-06 27.9 0.0 2.4e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Ureidoglycolate lyase Prim-Pol PF09250.11 KOO32392.1 - 0.00076 19.9 0.9 0.11 12.9 0.2 2.1 1 1 1 2 2 2 2 Bifunctional DNA primase/polymerase, N-terminal zf-RING_2 PF13639.6 KOO32395.1 - 5.3e-08 33.1 10.3 7.5e-08 32.6 10.3 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOO32395.1 - 0.00067 19.3 3.4 0.0011 18.6 3.4 1.4 1 0 0 1 1 1 1 RING-like zinc finger C1_1 PF00130.22 KOO32395.1 - 0.0023 17.8 5.6 0.0023 17.8 5.6 1.6 1 1 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 KOO32395.1 - 0.027 14.4 7.4 0.04 13.8 7.4 1.3 1 0 0 1 1 1 0 PHD-finger GAGA PF09237.11 KOO32395.1 - 0.067 13.0 7.7 0.79 9.6 2.2 2.4 2 0 0 2 2 2 0 GAGA factor zf-C3HC4_3 PF13920.6 KOO32395.1 - 0.16 11.9 10.6 0.29 11.0 10.6 1.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zf_RING PF16744.5 KOO32395.1 - 0.17 12.0 3.4 0.33 11.1 3.4 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger zf-ANAPC11 PF12861.7 KOO32395.1 - 0.33 11.0 3.2 0.56 10.3 3.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD_4 PF16866.5 KOO32395.1 - 0.81 9.8 6.3 22 5.3 4.9 2.3 2 0 0 2 2 2 0 PHD-finger Ank_2 PF12796.7 KOO32396.1 - 8.3e-23 80.8 1.2 1e-17 64.5 0.4 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO32396.1 - 1.4e-20 72.8 1.3 3.7e-06 27.1 0.0 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 KOO32396.1 - 7.4e-19 67.9 0.3 1.5e-08 35.0 0.1 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO32396.1 - 6.6e-18 62.9 0.8 4.5e-06 26.6 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 KOO32396.1 - 1.4e-15 57.2 0.4 2.3e-09 37.3 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Phospholip_A2_2 PF05826.12 KOO32396.1 - 0.11 12.7 0.6 0.29 11.4 0.6 1.7 1 0 0 1 1 1 0 Phospholipase A2 Aminotran_1_2 PF00155.21 KOO32397.1 - 1.1e-87 294.5 0.0 1.3e-87 294.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 KOO32397.1 - 0.012 14.5 0.0 0.021 13.7 0.0 1.4 1 1 0 1 1 1 0 Alanine-glyoxylate amino-transferase EF-hand_6 PF13405.6 KOO32398.1 - 1.8e-19 67.9 1.7 3.3e-05 23.5 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO32398.1 - 1.3e-18 67.2 0.1 2.5e-08 34.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO32398.1 - 9.8e-18 62.3 0.2 1.1e-05 24.6 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO32398.1 - 2.4e-13 48.9 0.4 0.00064 19.1 0.0 4.2 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.9 KOO32398.1 - 6.9e-05 23.1 0.0 0.15 12.4 0.0 2.4 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO32398.1 - 0.00049 20.4 0.0 0.35 11.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO32398.1 - 0.019 14.8 0.4 19 5.2 0.1 3.5 2 1 2 4 4 4 0 EF-hand domain pair DUF5580 PF17743.1 KOO32398.1 - 0.028 13.0 0.0 0.12 10.9 0.0 1.7 1 1 0 2 2 2 0 Family of unknown function (DUF5580) HEPN_LA2681 PF18733.1 KOO32398.1 - 0.064 12.6 0.1 9.6 5.4 0.0 2.2 1 1 1 2 2 2 0 LA2681-like HEPN SAP PF02037.27 KOO32398.1 - 0.1 12.4 3.7 7.2 6.5 0.1 2.9 3 0 0 3 3 3 0 SAP domain E3_binding PF02817.17 KOO32398.1 - 0.16 12.3 0.4 6.1 7.3 0.1 2.7 2 0 0 2 2 2 0 e3 binding domain DnaJ PF00226.31 KOO32399.1 - 1.7e-06 28.0 0.0 4.8e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain TUDOR_5 PF18359.1 KOO32399.1 - 3.5e-05 23.4 0.1 8.9e-05 22.1 0.1 1.7 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 MTBP_C PF14920.6 KOO32399.1 - 0.92 9.2 8.8 1.6 8.5 8.8 1.4 1 0 0 1 1 1 0 MDM2-binding TFIIA PF03153.13 KOO32399.1 - 1.1 9.1 18.3 1.6 8.6 18.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit JmjC PF02373.22 KOO32400.1 - 2.1e-30 105.5 0.0 3.1e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase DUF2514 PF10721.9 KOO32400.1 - 0.11 12.6 0.3 0.29 11.2 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2514) Baculo_PEP_C PF04513.12 KOO32401.1 - 0.3 11.1 2.1 4.6 7.3 0.2 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HTH_15 PF12324.8 KOO32401.1 - 0.87 9.6 4.9 8.2 6.5 0.1 3.6 1 1 1 3 3 3 0 Helix-turn-helix domain of alkylmercury lyase DUF4359 PF14271.6 KOO32401.1 - 9 7.1 7.6 2.1 9.1 0.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4359) LRR_5 PF13306.6 KOO32402.1 - 1.3e-80 267.7 5.4 2.2e-42 144.1 1.2 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO32402.1 - 1.8e-13 50.0 0.0 0.022 14.5 0.0 6.0 2 1 4 6 6 6 4 Leucine rich repeat Peptidase_M8 PF01457.16 KOO32402.1 - 0.011 14.5 6.0 1.2 7.8 0.2 3.6 1 1 3 4 4 4 0 Leishmanolysin LRR_4 PF12799.7 KOO32402.1 - 0.14 12.6 0.0 1.1e+02 3.5 0.0 3.9 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) DUF3684 PF12449.8 KOO32402.1 - 0.37 8.5 5.9 3 5.5 0.1 3.7 3 1 2 5 5 5 0 Protein of unknown function (DUF3684) PilA4 PF18682.1 KOO32402.1 - 1.6 9.2 15.1 30 5.1 0.1 6.6 1 1 9 10 10 10 0 Pilin A4 NACHT PF05729.12 KOO32404.1 - 8.1e-08 32.3 0.4 1.6e-07 31.4 0.4 1.5 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 KOO32404.1 - 0.046 12.9 0.0 0.081 12.1 0.0 1.4 1 1 0 1 1 1 0 NB-ARC domain LRR_6 PF13516.6 KOO32405.1 - 9e-14 50.3 10.4 0.19 11.9 0.0 8.3 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 KOO32405.1 - 0.0027 18.0 1.5 30 5.7 0.0 5.3 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_4 PF12799.7 KOO32405.1 - 0.0027 18.1 0.1 8 7.0 0.0 4.6 4 1 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO32405.1 - 0.0056 16.4 0.1 16 5.4 0.0 4.1 5 0 0 5 5 5 2 Leucine rich repeat NLRC4_HD2 PF17776.1 KOO32405.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 NLRC4 helical domain HD2 HALZ PF02183.18 KOO32406.1 - 0.003 17.7 7.7 0.18 12.0 0.4 3.0 2 1 1 3 3 3 2 Homeobox associated leucine zipper Syntaxin PF00804.25 KOO32406.1 - 3.5 7.3 9.6 8.5 6.0 0.1 3.0 1 1 2 3 3 3 0 Syntaxin PIF1 PF05970.14 KOO32407.1 - 1e-22 80.8 0.0 1.2e-09 37.8 0.0 3.2 2 1 1 3 3 3 3 PIF1-like helicase AAA_30 PF13604.6 KOO32407.1 - 4.5e-17 62.4 0.6 2.6e-16 59.9 0.0 2.6 3 1 0 3 3 2 1 AAA domain AAA_19 PF13245.6 KOO32407.1 - 5.3e-13 49.5 0.1 2.2e-12 47.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO32407.1 - 7.3e-07 29.2 0.2 0.00096 19.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KOO32407.1 - 1.2e-06 28.8 0.0 3.2e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain zf-CCHC PF00098.23 KOO32407.1 - 1.4e-06 28.1 5.5 1.4e-06 28.1 5.5 3.0 3 0 0 3 3 3 1 Zinc knuckle UvrD_C_2 PF13538.6 KOO32407.1 - 7.5e-06 25.7 0.2 2e-05 24.3 0.2 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 KOO32407.1 - 1.5e-05 23.1 0.0 2.9e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Helicase Mg_chelatase PF01078.21 KOO32407.1 - 0.00095 18.6 0.2 0.0023 17.4 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOO32407.1 - 0.0014 18.6 0.0 0.0035 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO32407.1 - 0.0016 18.9 0.1 0.0091 16.4 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 KOO32407.1 - 0.0095 16.2 0.1 0.024 14.9 0.1 1.7 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 KOO32407.1 - 0.03 14.3 0.0 0.076 12.9 0.0 1.7 1 0 0 1 1 1 0 NTPase AAA PF00004.29 KOO32407.1 - 0.035 14.5 0.0 0.29 11.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 KOO32407.1 - 0.085 12.1 0.0 0.46 9.7 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 KOO32407.1 - 0.11 13.0 0.0 0.3 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KOO32407.1 - 0.11 12.8 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DEAD PF00270.29 KOO32407.1 - 0.13 12.0 0.0 16 5.2 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase UvrD-helicase PF00580.21 KOO32407.1 - 0.14 11.6 0.0 0.31 10.5 0.0 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain zf-CCHC_2 PF13696.6 KOO32407.1 - 0.15 11.9 5.4 0.11 12.4 2.1 2.3 2 0 0 2 2 2 0 Zinc knuckle AAA_7 PF12775.7 KOO32407.1 - 0.18 11.3 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region zf-CCHC_5 PF14787.6 KOO32407.1 - 0.41 10.4 3.2 0.89 9.3 2.3 2.1 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger DUF563 PF04577.14 KOO32408.1 - 2.4e-07 31.1 0.0 5.8e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF563) ART PF01129.18 KOO32409.1 - 0.00095 18.5 0.0 0.0048 16.2 0.0 2.0 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase CHAP PF05257.16 KOO32409.1 - 0.011 16.3 0.0 0.025 15.1 0.0 1.6 1 0 0 1 1 1 0 CHAP domain ADPrib_exo_Tox PF03496.14 KOO32409.1 - 0.17 11.2 0.0 1.9 7.8 0.0 2.2 2 1 0 2 2 2 0 ADP-ribosyltransferase exoenzyme Bromodomain PF00439.25 KOO32410.1 - 9.5e-22 76.9 0.1 1.5e-21 76.3 0.1 1.3 1 0 0 1 1 1 1 Bromodomain BET PF17035.5 KOO32410.1 - 5.5e-05 23.2 0.0 0.00013 22.1 0.0 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation GDP_Man_Dehyd PF16363.5 KOO32411.1 - 8.7e-60 202.9 0.0 9.8e-60 202.7 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOO32411.1 - 9.5e-17 61.3 0.1 1.3e-16 60.9 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO32412.1 - 2.8e-77 260.3 0.2 3.2e-77 260.2 0.2 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOO32412.1 - 1e-45 156.1 0.1 1.1e-45 155.9 0.1 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOO32412.1 - 1.2e-07 31.1 0.0 1.6e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KOO32412.1 - 0.01 15.0 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NmrA PF05368.13 KOO32412.1 - 0.081 12.5 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family TTL PF03133.15 KOO32413.1 - 1.4e-53 182.0 0.0 1.6e-35 122.7 0.0 2.1 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 KOO32413.1 - 2.6e-08 33.5 0.0 0.00097 18.5 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 KOO32413.1 - 2e-07 30.5 0.0 2.3e-05 23.8 0.0 2.9 2 1 1 3 3 3 1 YheC/D like ATP-grasp RimK PF08443.11 KOO32413.1 - 0.0057 16.3 0.0 1.5 8.4 0.0 2.2 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 KOO32413.1 - 0.0069 16.5 0.0 0.15 12.1 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain LRR_6 PF13516.6 KOO32414.1 - 2.7e-35 117.4 12.5 3.4e-05 23.5 0.0 7.6 7 0 0 7 7 7 7 Leucine Rich repeat LRR_4 PF12799.7 KOO32414.1 - 2.3e-06 27.8 4.8 0.41 11.1 1.1 5.5 4 3 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO32414.1 - 8.2e-06 25.7 0.0 18 6.4 0.1 6.0 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO32414.1 - 0.00049 19.8 6.3 1.9 8.3 0.1 5.8 5 3 0 5 5 5 1 Leucine rich repeat HOASN PF14515.6 KOO32414.1 - 0.0024 18.2 13.3 2 8.8 1.1 5.1 2 1 3 5 5 5 2 Haem-oxygenase-associated N-terminal helices CbiG_N PF11760.8 KOO32414.1 - 0.099 12.7 10.6 7.1 6.7 0.0 5.0 4 1 1 5 5 5 0 Cobalamin synthesis G N-terminal EIF_2_alpha PF07541.12 KOO32414.1 - 0.17 12.0 0.0 3.5 7.8 0.0 2.5 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Arm-DNA-bind_1 PF09003.10 KOO32414.1 - 0.29 11.3 14.0 1.5 9.0 0.1 4.5 3 1 2 5 5 5 0 Bacteriophage lambda integrase, Arm DNA-binding domain DUF3168 PF11367.8 KOO32414.1 - 0.8 9.9 3.4 2.2 8.5 0.2 3.0 2 1 2 4 4 4 0 Protein of unknown function (DUF3168) CoatB PF10389.9 KOO32414.1 - 6.9 6.6 8.8 18 5.3 0.1 4.3 4 1 1 5 5 5 0 Bacteriophage coat protein B MFS_1 PF07690.16 KOO32415.1 - 7.2e-05 21.9 8.0 0.00011 21.2 8.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily SNF2_N PF00176.23 KOO32417.1 - 5.2e-49 166.8 0.1 8.8e-49 166.1 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO32417.1 - 9.2e-16 58.2 0.0 1.6e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO32417.1 - 3.5e-06 26.9 0.0 6.2e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO32417.1 - 8.6e-05 22.6 0.0 0.00017 21.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KOO32417.1 - 0.013 14.7 0.0 0.091 11.9 0.0 2.1 2 0 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 KOO32417.1 - 0.21 11.2 0.0 0.38 10.4 0.0 1.3 1 0 0 1 1 1 0 SWI2/SNF2 ATPase YL1 PF05764.13 KOO32418.1 - 0.11 12.6 1.0 0.16 12.0 1.0 1.2 1 0 0 1 1 1 0 YL1 nuclear protein ERO1 PF04137.15 KOO32419.1 - 8.7e-82 275.1 0.0 1.5e-80 271.1 0.0 2.0 1 1 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Fer4_22 PF17179.4 KOO32419.1 - 0.021 15.6 0.1 0.14 13.0 0.2 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain LRR_6 PF13516.6 KOO32420.1 - 2.8e-19 67.5 37.1 0.0019 18.1 0.3 11.1 13 0 0 13 13 13 6 Leucine Rich repeat EF-hand_1 PF00036.32 KOO32420.1 - 1.4e-09 36.8 0.1 0.0003 20.1 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO32420.1 - 2.3e-07 30.2 0.6 0.004 17.0 0.1 3.7 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO32420.1 - 1.3e-06 28.8 0.4 3.5e-06 27.4 0.4 1.7 1 0 0 1 1 1 1 EF-hand domain pair LRR_1 PF00560.33 KOO32420.1 - 6.1e-05 23.0 1.6 2.1e+02 3.1 0.0 8.0 11 0 0 11 11 11 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO32420.1 - 0.0071 16.1 7.6 21 5.0 0.0 7.0 7 1 1 8 8 8 0 Leucine rich repeat SPARC_Ca_bdg PF10591.9 KOO32420.1 - 0.036 14.4 0.1 0.085 13.2 0.1 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 KOO32420.1 - 0.036 13.6 5.5 0.43 10.2 0.0 2.8 3 0 0 3 3 3 0 EF hand EF-hand_8 PF13833.6 KOO32420.1 - 0.23 11.3 0.5 0.84 9.5 0.2 2.2 2 0 0 2 2 2 0 EF-hand domain pair LRR_4 PF12799.7 KOO32420.1 - 1 9.9 22.3 5.3 7.6 0.0 7.3 7 3 0 7 7 7 0 Leucine Rich repeats (2 copies) FAM219A PF15260.6 KOO32421.1 - 1.2e-07 32.2 3.0 2.4e-07 31.2 3.0 1.6 1 1 0 1 1 1 1 Protein family FAM219A CRIM PF16978.5 KOO32421.1 - 0.14 12.3 1.0 0.2 11.8 0.8 1.3 1 1 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), middle CRIM domain EF-hand_1 PF00036.32 KOO32422.1 - 2.5e-13 48.5 1.9 9.9e-06 24.8 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO32422.1 - 4.3e-13 48.0 0.3 2.5e-06 26.9 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO32422.1 - 3.2e-11 43.5 0.2 5.3e-11 42.8 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO32422.1 - 3.6e-11 42.7 0.3 9.8e-07 28.5 0.4 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO32422.1 - 2.7e-10 39.3 1.8 9e-05 21.8 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO32422.1 - 0.00016 21.9 0.0 0.00028 21.2 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO32422.1 - 0.00032 20.6 0.1 0.00079 19.3 0.1 1.6 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO32422.1 - 0.013 15.3 0.1 0.026 14.4 0.1 1.5 1 0 0 1 1 1 0 EF hand DUF1133 PF06576.11 KOO32422.1 - 0.017 14.5 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) SPARC_Ca_bdg PF10591.9 KOO32422.1 - 0.042 14.2 0.0 0.073 13.4 0.0 1.5 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3293 PF11697.8 KOO32422.1 - 0.17 12.4 0.0 0.28 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3293) CN_hydrolase PF00795.22 KOO32426.1 - 2.4e-29 102.5 0.0 3.4e-29 102.0 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 KOO32426.1 - 1.7e-24 86.3 0.0 4.9e-24 84.8 0.0 1.7 1 1 0 1 1 1 1 NAD synthase DUF1174 PF06671.11 KOO32426.1 - 0.42 10.4 2.3 1 9.1 2.3 1.7 1 0 0 1 1 1 0 Repeat of unknown function (DUF1174) GLTP PF08718.11 KOO32427.1 - 1.5e-17 64.2 0.0 2.5e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) EF-hand_6 PF13405.6 KOO32427.1 - 2.6e-05 23.8 0.2 6.6e-05 22.5 0.2 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO32427.1 - 4.5e-05 22.7 0.8 0.00012 21.4 0.8 1.8 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO32427.1 - 0.0051 16.3 0.4 0.012 15.0 0.4 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO32427.1 - 0.0086 16.5 0.1 0.02 15.4 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair VPS13_C PF16909.5 KOO32427.1 - 0.25 11.1 1.0 8.5 6.1 0.3 2.6 1 1 2 3 3 3 0 Vacuolar-sorting-associated 13 protein C-terminal PHB_acc_N PF07879.11 KOO32428.1 - 0.039 14.1 0.5 0.063 13.4 0.5 1.3 1 0 0 1 1 1 0 PHB/PHA accumulation regulator DNA-binding domain Arm PF00514.23 KOO32429.1 - 1.3e-17 63.1 3.6 9.7e-06 25.5 0.1 3.5 2 1 1 3 3 3 3 Armadillo/beta-catenin-like repeat Nucleotid_trans PF03407.16 KOO32429.1 - 0.24 11.3 0.0 0.52 10.3 0.0 1.5 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase MORN PF02493.20 KOO32430.1 - 6.5e-29 98.1 36.3 2.2e-06 27.2 0.2 8.8 9 0 0 9 9 9 8 MORN repeat VHS PF00790.19 KOO32431.1 - 0.11 12.3 1.5 0.5 10.2 1.5 2.0 1 1 0 1 1 1 0 VHS domain DUF3636 PF12331.8 KOO32431.1 - 2.6 7.9 6.3 5.9 6.7 1.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3636) UBA PF00627.31 KOO32433.1 - 0.041 13.8 0.6 0.21 11.5 0.1 2.5 2 1 0 2 2 2 0 UBA/TS-N domain DUF1075 PF06388.11 KOO32433.1 - 0.096 12.7 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) RuvA_C PF07499.13 KOO32433.1 - 0.16 12.4 1.2 0.27 11.7 0.2 1.8 2 0 0 2 2 2 0 RuvA, C-terminal domain TMEM65 PF10507.9 KOO32436.1 - 3.1e-36 123.6 6.0 4.8e-36 123.0 6.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 65 GAF PF01590.26 KOO32436.1 - 1.3e-13 51.7 0.1 8.4e-13 49.1 0.1 2.2 1 1 0 1 1 1 1 GAF domain GAF_2 PF13185.6 KOO32436.1 - 1.8e-10 41.3 0.0 0.00011 22.5 0.0 3.2 3 0 0 3 3 3 2 GAF domain EF-hand_9 PF14658.6 KOO32436.1 - 3.8e-05 23.9 0.0 6.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_6 PF13405.6 KOO32436.1 - 6.1e-05 22.6 0.0 0.00018 21.2 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO32436.1 - 0.00012 21.4 0.0 0.0023 17.4 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO32436.1 - 0.00052 20.4 0.0 0.0012 19.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair Romo1 PF10247.9 KOO32436.1 - 0.0035 17.7 0.8 0.1 13.0 0.1 2.5 2 0 0 2 2 2 1 Reactive mitochondrial oxygen species modulator 1 EF-hand_5 PF13202.6 KOO32436.1 - 0.0098 15.4 0.0 0.033 13.7 0.0 1.9 1 0 0 1 1 1 1 EF hand Tail_spike_N PF18668.1 KOO32436.1 - 0.014 15.2 0.0 0.048 13.5 0.0 1.8 2 0 0 2 2 2 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain Rossmann-like PF10727.9 KOO32436.1 - 0.13 12.2 0.1 0.39 10.6 0.0 1.8 2 0 0 2 2 2 0 Rossmann-like domain GAF_3 PF13492.6 KOO32436.1 - 0.14 12.6 0.0 14 6.1 0.0 2.9 3 0 0 3 3 3 0 GAF domain VPS9 PF02204.18 KOO32437.1 - 1.5e-19 70.1 0.1 2.4e-19 69.5 0.1 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain LRR_6 PF13516.6 KOO32438.1 - 5.2e-13 47.9 3.4 0.034 14.2 0.1 7.6 7 0 0 7 7 7 4 Leucine Rich repeat Skp1 PF01466.19 KOO32438.1 - 0.0015 18.6 0.0 0.0089 16.1 0.0 2.3 3 0 0 3 3 3 1 Skp1 family, dimerisation domain DUF3754 PF12576.8 KOO32441.1 - 1.4e-13 50.9 0.0 2.4e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) DUF5087 PF17006.5 KOO32441.1 - 0.014 15.0 0.0 0.02 14.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5087) Ion_trans PF00520.31 KOO32442.1 - 4.4e-15 55.6 5.9 8.1e-15 54.7 5.9 1.5 1 1 0 1 1 1 1 Ion transport protein tRNA_synthFbeta PF17759.1 KOO32443.1 - 0.15 11.5 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Phenylalanyl tRNA synthetase beta chain CLM domain zf-NOSIP PF15906.5 KOO32444.1 - 7.9e-14 51.6 0.0 1.7e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 KOO32444.1 - 1.5e-12 47.5 1.8 5.6e-07 29.2 0.1 2.6 2 1 0 2 2 2 2 Rtf2 RING-finger U-box PF04564.15 KOO32444.1 - 9.8e-06 25.7 0.3 0.28 11.4 0.0 3.1 3 1 0 3 3 3 2 U-box domain zf-Nse PF11789.8 KOO32444.1 - 0.02 14.7 0.1 4.8 7.1 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit DUF3134 PF11332.8 KOO32446.1 - 0.17 12.2 2.3 0.29 11.5 2.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3134) DHHC PF01529.20 KOO32447.1 - 1.3e-31 109.5 1.8 1.8e-31 109.0 1.8 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase EF-hand_5 PF13202.6 KOO32448.1 - 0.00026 20.3 0.8 0.0006 19.2 0.8 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO32448.1 - 0.0017 17.8 0.1 0.0035 16.8 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO32448.1 - 0.013 15.9 0.0 0.027 14.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO32448.1 - 0.015 15.2 0.1 0.036 14.0 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain BTAD PF03704.17 KOO32448.1 - 0.047 14.1 0.6 0.17 12.3 0.1 1.8 1 1 1 2 2 2 0 Bacterial transcriptional activator domain DUF1707 PF08044.11 KOO32448.1 - 0.084 13.0 0.1 0.31 11.1 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) SpoU_methylase PF00588.19 KOO32449.1 - 2.8e-20 72.9 0.0 8.1e-19 68.2 0.0 2.5 1 1 0 1 1 1 1 SpoU rRNA Methylase family Ank_2 PF12796.7 KOO32450.1 - 2.9e-18 66.2 0.7 7.7e-05 23.2 0.0 5.3 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO32450.1 - 2.5e-16 59.8 0.0 3.6e-06 27.4 0.0 4.2 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO32450.1 - 1.1e-11 44.7 0.7 0.006 16.9 0.0 5.8 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO32450.1 - 1.8e-10 40.1 0.9 0.0084 16.5 0.0 5.7 6 1 0 6 6 6 2 Ankyrin repeat Ank PF00023.30 KOO32450.1 - 8.8e-10 38.6 0.0 0.00023 21.5 0.0 5.3 6 0 0 6 6 6 2 Ankyrin repeat LRR_8 PF13855.6 KOO32451.1 - 8.9e-06 25.4 0.1 1.9e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KOO32451.1 - 4.8e-05 23.6 0.1 0.00019 21.8 0.1 2.1 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) AAA_15 PF13175.6 KOO32452.1 - 0.0094 15.7 7.5 0.017 14.8 7.5 1.3 1 0 0 1 1 1 1 AAA ATPase domain V_ATPase_I_N PF18670.1 KOO32452.1 - 0.026 14.9 0.6 0.026 14.9 0.6 3.6 2 1 1 3 3 3 0 V-type ATPase subunit I, N-terminal domain Phage_min_cap2 PF06152.11 KOO32452.1 - 0.066 12.1 1.9 0.11 11.4 1.9 1.3 1 0 0 1 1 1 0 Phage minor capsid protein 2 Cas_DxTHG PF09455.10 KOO32452.1 - 0.11 12.0 2.4 0.18 11.4 2.4 1.3 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family CobN-Mg_chel PF02514.16 KOO32452.1 - 0.23 9.1 6.9 0.33 8.6 6.9 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase 5_nucleotid PF05761.14 KOO32452.1 - 4.9 5.9 6.5 8.1 5.2 6.5 1.3 1 0 0 1 1 1 0 5' nucleotidase family Exonuc_VII_L PF02601.15 KOO32452.1 - 7.3 6.1 12.9 0.31 10.6 6.9 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit Ank_2 PF12796.7 KOO32454.1 - 3.4e-36 123.7 11.3 6e-13 49.2 1.9 6.2 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO32454.1 - 5.9e-30 103.3 7.1 4.4e-10 39.9 0.5 7.4 3 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO32454.1 - 1.4e-19 68.1 5.1 0.018 15.5 0.0 9.4 10 0 0 10 10 10 5 Ankyrin repeat Ank PF00023.30 KOO32454.1 - 2e-19 69.1 8.3 0.0075 16.7 0.1 9.4 10 0 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 KOO32454.1 - 2.1e-19 69.3 8.5 0.00011 22.5 0.7 8.7 5 2 4 9 9 9 6 Ankyrin repeats (many copies) ART PF01129.18 KOO32454.1 - 2.8e-05 23.5 0.0 0.00016 21.0 0.0 2.1 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO32454.1 - 5.3e-05 22.6 0.9 0.0019 17.6 1.2 2.9 2 1 0 2 2 2 1 ADP-ribosyltransferase exoenzyme DUF2877 PF11392.8 KOO32454.1 - 0.0094 16.7 0.1 0.076 13.7 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2877) NUDIX PF00293.28 KOO32454.1 - 0.025 14.6 0.1 0.085 12.9 0.1 1.9 1 0 0 1 1 1 0 NUDIX domain DUF4050 PF13259.6 KOO32454.1 - 1.7 9.0 5.0 2.8 8.2 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) RVT_2 PF07727.14 KOO32455.1 - 0.022 14.4 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) 2OG-FeII_Oxy_2 PF13532.6 KOO32457.1 - 0.0024 18.1 0.0 0.0045 17.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily WHEP-TRS PF00458.20 KOO32458.1 - 3e-05 24.1 2.8 3e-05 24.1 2.8 1.9 2 1 0 2 2 2 1 WHEP-TRS domain Sel1 PF08238.12 KOO32459.1 - 1.2e-217 699.3 320.9 3.8e-07 30.6 0.7 40.3 40 0 0 40 40 40 40 Sel1 repeat CRISPR_Cas2 PF09827.9 KOO32459.1 - 0.0099 16.0 0.1 1e+02 3.2 0.0 6.0 4 0 0 4 4 4 0 CRISPR associated protein Cas2 DUF4521 PF15021.6 KOO32459.1 - 0.021 14.8 0.3 25 4.7 0.0 4.8 4 1 1 5 5 5 0 Protein of unknown function (DUF4521) GlgS PF08971.11 KOO32459.1 - 1.1 9.4 19.8 1.4e+02 2.6 0.0 9.8 10 0 0 10 10 10 0 Glycogen synthesis protein RIC1 PF07064.13 KOO32459.1 - 1.7 8.0 7.8 70 2.7 0.0 6.8 9 0 0 9 9 9 0 RIC1 DUF4307 PF14155.6 KOO32459.1 - 4.4 7.2 31.4 10 6.0 0.1 10.6 9 4 4 14 14 14 0 Domain of unknown function (DUF4307) MBG_2 PF18676.1 KOO32459.1 - 5.8 7.6 11.1 1.2e+02 3.4 0.0 7.5 9 1 1 10 10 10 0 MBG domain (YGX type) DUF2321 PF10083.9 KOO32460.1 - 1.7 8.3 18.9 3.3 7.3 0.5 4.4 1 1 3 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2321) Na_Ca_ex PF01699.24 KOO32461.1 - 8.1e-33 113.5 24.1 1.8e-21 76.7 9.9 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein TFIIE-A_C PF11521.8 KOO32461.1 - 0.084 13.2 0.8 4.2 7.7 0.0 2.4 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha LRR_5 PF13306.6 KOO32462.1 - 5.9e-19 68.3 0.0 7.8e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO32462.1 - 0.0025 17.6 0.0 1.9 8.3 0.0 3.7 3 2 1 4 4 4 1 Leucine rich repeat SLATT_1 PF18181.1 KOO32463.1 - 3e-19 69.1 1.1 3e-19 69.1 1.1 2.2 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain 1 DUF4231 PF14015.6 KOO32463.1 - 1.7e-10 41.3 5.9 2.9e-09 37.3 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF4231) SLATT_3 PF18184.1 KOO32463.1 - 0.067 13.3 1.2 0.13 12.5 0.1 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 4HB_MCP_1 PF12729.7 KOO32463.1 - 0.17 11.4 2.9 35 3.9 0.1 3.3 3 0 0 3 3 3 0 Four helix bundle sensory module for signal transduction Choline_transpo PF04515.12 KOO32464.1 - 9e-66 222.3 38.4 9e-66 222.3 38.4 2.6 3 0 0 3 3 3 1 Plasma-membrane choline transporter EF-hand_1 PF00036.32 KOO32465.1 - 2.7e-27 92.2 5.4 1e-05 24.7 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO32465.1 - 8.5e-26 89.6 3.0 1.5e-05 24.7 0.1 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_7 PF13499.6 KOO32465.1 - 7.3e-24 84.0 0.1 3.9e-10 40.0 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO32465.1 - 2.5e-23 80.0 0.5 0.00012 21.7 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO32465.1 - 6.7e-20 69.6 12.3 7.7e-05 22.0 0.0 4.7 5 0 0 5 5 5 4 EF hand EF-hand_4 PF12763.7 KOO32465.1 - 1.8e-14 53.6 0.2 0.017 15.1 0.0 4.2 3 1 1 4 4 4 4 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO32465.1 - 8.3e-06 25.6 0.7 3.5 7.6 0.0 4.1 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 KOO32465.1 - 0.021 15.1 0.1 5.7 7.3 0.0 3.5 3 1 1 4 4 4 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO32465.1 - 0.025 14.9 0.0 5 7.5 0.0 3.3 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3459 PF11941.8 KOO32465.1 - 0.22 11.9 3.2 2.8 8.3 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3459) rve PF00665.26 KOO32466.1 - 2.2e-07 31.1 0.0 5.9e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 KOO32466.1 - 1.3e-05 25.0 0.0 0.00016 21.4 0.0 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 KOO32466.1 - 0.0031 17.3 0.2 0.0072 16.2 0.2 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain Pkinase_Tyr PF07714.17 KOO32469.1 - 4.3e-39 134.3 0.0 5.1e-18 65.3 0.0 3.2 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KOO32469.1 - 6.2e-33 114.3 0.0 7.4e-32 110.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO32469.1 - 0.0025 17.8 0.9 0.017 15.1 0.0 2.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family zf-primase PF09329.11 KOO32470.1 - 0.17 11.7 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Primase zinc finger PDZ_6 PF17820.1 KOO32471.1 - 0.0002 21.1 0.1 0.00057 19.7 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO32471.1 - 0.052 13.9 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 PDZ domain RVT_2 PF07727.14 KOO32472.1 - 0.021 14.5 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) PROCN PF08083.11 KOO32473.1 - 1.7e-234 777.9 4.3 3.1e-234 777.1 4.3 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 KOO32473.1 - 7.9e-127 421.6 0.4 1.4e-126 420.8 0.4 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 KOO32473.1 - 2.4e-89 297.3 2.5 6e-89 296.0 2.5 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 KOO32473.1 - 8.8e-87 288.7 2.5 2e-86 287.6 2.5 1.6 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 KOO32473.1 - 2.3e-72 241.3 0.0 4.3e-72 240.5 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 KOO32473.1 - 2.9e-53 179.0 0.2 8.1e-53 177.6 0.1 1.8 2 0 0 2 2 2 1 PROCT (NUC072) domain RRM_4 PF10598.9 KOO32473.1 - 1.1e-46 157.0 0.3 3.5e-46 155.5 0.3 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 KOO32473.1 - 3.7e-07 30.1 0.0 8.3e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF4407 PF14362.6 KOO32474.1 - 0.081 12.3 15.4 0.1 11.9 15.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 KOO32474.1 - 0.23 11.9 7.7 0.32 11.4 7.7 1.3 1 0 0 1 1 1 0 Fez1 PolyA_pol PF01743.20 KOO32474.1 - 0.61 10.5 4.6 3.3 8.1 4.6 2.0 1 1 0 1 1 1 0 Poly A polymerase head domain DUF3584 PF12128.8 KOO32474.1 - 0.65 7.4 13.0 0.73 7.3 13.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Nucleotid_trans PF03407.16 KOO32476.1 - 6.5e-21 75.3 0.0 1.1e-20 74.5 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase GBP PF02263.19 KOO32478.1 - 2.7e-16 59.6 0.0 4.4e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Bactofilin PF04519.13 KOO32479.1 - 0.039 14.3 4.2 0.21 11.9 0.8 2.6 2 0 0 2 2 2 0 Polymer-forming cytoskeletal Trehalase PF01204.18 KOO32481.1 - 0.051 12.4 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Trehalase Spermine_synth PF01564.17 KOO32482.1 - 2.8e-61 206.2 0.0 4.5e-61 205.6 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KOO32482.1 - 7.6e-22 77.0 0.1 1.3e-21 76.2 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 KOO32482.1 - 0.0034 18.0 0.1 0.01 16.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_30 PF05430.11 KOO32482.1 - 0.16 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Pkinase_Tyr PF07714.17 KOO32483.1 - 3e-09 36.6 0.0 3.5e-09 36.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO32483.1 - 4.4e-07 29.5 0.0 5.6e-07 29.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Nuf2 PF03800.14 KOO32484.1 - 1.2e-31 109.7 0.0 4.2e-31 107.9 0.0 1.9 1 0 0 1 1 1 1 Nuf2 family DHR10 PF18595.1 KOO32484.1 - 5.2e-06 26.5 30.9 5.2e-06 26.5 30.9 3.7 3 1 0 3 3 3 1 Designed helical repeat protein 10 domain EF-hand_5 PF13202.6 KOO32486.1 - 4.8e-07 29.0 0.1 1.4e-06 27.5 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO32486.1 - 1.9e-05 25.1 0.0 3.4e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO32486.1 - 3.9e-05 23.2 0.1 0.00016 21.3 0.1 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO32486.1 - 7e-05 22.1 0.0 0.0002 20.7 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO32486.1 - 0.0021 17.9 0.1 0.044 13.6 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair IQ PF00612.27 KOO32488.1 - 1.4e-05 24.4 16.3 0.0015 18.2 1.2 3.6 3 0 0 3 3 3 2 IQ calmodulin-binding motif PDZ_6 PF17820.1 KOO32488.1 - 0.016 15.0 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 KOO32488.1 - 0.066 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 PDZ domain DUF148 PF02520.17 KOO32488.1 - 6.8 6.9 8.6 1.6 8.9 2.5 2.4 3 0 0 3 3 3 0 Domain of unknown function DUF148 cNMP_binding PF00027.29 KOO32489.1 - 6.1e-68 224.9 2.0 1.5e-18 66.7 0.0 4.9 5 0 0 5 5 5 4 Cyclic nucleotide-binding domain Pkinase PF00069.25 KOO32489.1 - 1.4e-63 214.8 0.0 2.1e-63 214.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32489.1 - 3.2e-35 121.7 0.0 5.8e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO32489.1 - 0.0012 18.3 0.0 0.0026 17.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO32489.1 - 0.038 13.3 0.1 0.1 11.9 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO32489.1 - 0.066 12.0 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 KOO32489.1 - 0.078 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO32489.1 - 0.14 11.0 0.0 0.24 10.3 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain EF-hand_6 PF13405.6 KOO32490.1 - 1.7e-28 96.0 7.1 1.8e-06 27.4 0.1 5.4 5 0 0 5 5 5 5 EF-hand domain EF-hand_1 PF00036.32 KOO32490.1 - 7.6e-28 94.0 9.4 5.5e-06 25.6 0.4 5.3 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 KOO32490.1 - 1.1e-21 77.1 10.5 2.2e-07 31.2 3.3 3.7 1 1 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO32490.1 - 4.7e-19 67.0 16.2 0.00021 20.6 1.4 5.4 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.6 KOO32490.1 - 1.4e-17 63.2 13.0 0.00021 21.1 0.0 5.2 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_9 PF14658.6 KOO32490.1 - 0.01 16.1 0.1 12 6.3 0.0 3.8 4 0 0 4 4 4 0 EF-hand domain Caleosin PF05042.13 KOO32490.1 - 0.013 15.4 0.3 26 4.7 0.0 3.6 2 2 2 4 4 4 0 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO32490.1 - 0.047 14.0 0.1 10 6.5 0.0 2.8 2 2 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region CCD48 PF15799.5 KOO32490.1 - 0.055 11.8 0.0 0.97 7.7 0.0 2.4 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 48 EF-hand_10 PF14788.6 KOO32490.1 - 0.067 13.1 1.8 14 5.7 0.0 3.9 5 0 0 5 5 5 0 EF hand Pkinase PF00069.25 KOO32492.1 - 3.9e-65 219.8 0.0 5.7e-65 219.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32492.1 - 5.5e-37 127.5 0.0 7.2e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO32492.1 - 0.00031 19.7 0.0 0.0005 19.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO32492.1 - 0.0011 18.4 0.1 0.002 17.5 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 KOO32492.1 - 0.0012 19.5 0.1 0.0024 18.6 0.1 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 KOO32492.1 - 0.0018 18.2 0.1 0.076 12.9 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 KOO32492.1 - 0.0032 17.1 0.0 1.5 8.4 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 ATP_bind_1 PF03029.17 KOO32492.1 - 0.19 11.5 0.1 1 9.1 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein EF-hand_1 PF00036.32 KOO32493.1 - 3.2e-15 54.5 2.9 7.3e-07 28.3 0.5 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO32493.1 - 4.9e-12 44.8 3.0 0.00034 20.3 0.0 3.4 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO32493.1 - 1.1e-11 45.0 0.7 1.1e-11 45.0 0.7 1.8 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO32493.1 - 2.1e-10 39.6 6.4 5.2e-05 22.6 0.3 2.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO32493.1 - 1.6e-08 34.2 1.4 2.9e-07 30.2 0.6 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO32493.1 - 6.9e-05 23.1 0.1 0.00021 21.6 0.1 1.8 2 0 0 2 2 2 1 EF-hand domain TPR_12 PF13424.6 KOO32493.1 - 0.0001 22.6 0.1 0.00018 21.7 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO32493.1 - 0.00056 19.7 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat EF-hand_4 PF12763.7 KOO32493.1 - 0.003 17.5 1.4 0.011 15.7 0.2 1.9 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO32493.1 - 0.014 15.6 1.0 0.025 14.8 0.9 1.5 1 1 0 1 1 1 0 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KOO32493.1 - 0.029 14.7 0.2 0.043 14.1 0.2 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region LXG PF04740.12 KOO32493.1 - 0.044 13.5 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 LXG domain of WXG superfamily DUF1161 PF06649.12 KOO32493.1 - 0.18 12.0 0.1 2.1 8.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1161) TPR_12 PF13424.6 KOO32494.1 - 3.8e-25 88.0 28.2 1.8e-09 37.7 0.2 5.5 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 KOO32494.1 - 1.3e-16 59.8 41.0 0.0067 16.3 0.5 8.9 8 2 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 KOO32494.1 - 1.5e-06 27.8 6.1 0.88 9.5 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO32494.1 - 1.4e-05 24.9 7.5 20 5.7 0.0 6.9 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO32494.1 - 2.2e-05 24.2 22.0 3.6 7.9 0.1 6.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 KOO32494.1 - 0.0052 16.7 20.6 1.8 8.8 0.0 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_4 PF07721.14 KOO32494.1 - 1.3 9.8 0.1 1.3 9.8 0.1 7.9 8 1 1 9 9 9 0 Tetratricopeptide repeat Pkinase PF00069.25 KOO32496.1 - 3.5e-67 226.5 0.0 4.2e-67 226.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32496.1 - 2e-27 96.1 0.0 3.3e-27 95.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO32496.1 - 2.1e-06 27.3 0.0 2.2e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOO32496.1 - 7.4e-05 21.8 0.0 0.0001 21.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOO32496.1 - 0.001 19.0 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Imm7 PF15585.6 KOO32496.1 - 0.13 12.5 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 7 UFD1 PF03152.14 KOO32498.1 - 5.4e-10 39.0 0.0 8.3e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 UBX PF00789.20 KOO32498.1 - 0.00037 20.6 0.0 0.00074 19.7 0.0 1.4 1 0 0 1 1 1 1 UBX domain Prenyltrans PF00432.21 KOO32499.1 - 3.3e-39 132.3 8.1 3.2e-10 39.6 0.3 5.7 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 KOO32499.1 - 0.009 15.1 0.0 0.68 9.0 0.0 2.4 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain zf-HIT PF04438.16 KOO32500.1 - 1.9e-06 27.6 9.6 3.3e-06 26.9 9.6 1.3 1 0 0 1 1 1 1 HIT zinc finger Neur_chan_memb PF02932.16 KOO32501.1 - 1e-06 29.0 0.1 1.6e-06 28.3 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Bac_DNA_binding PF00216.21 KOO32501.1 - 0.077 13.2 0.0 0.29 11.4 0.0 1.9 2 0 0 2 2 2 0 Bacterial DNA-binding protein PARP PF00644.20 KOO32502.1 - 1.5e-06 27.9 0.0 2.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF484 PF04340.12 KOO32502.1 - 0.00091 19.0 0.8 0.0015 18.2 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF484 FAP206 PF12018.8 KOO32502.1 - 0.29 10.6 1.1 0.43 10.1 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF3450 PF11932.8 KOO32502.1 - 0.48 9.7 9.1 0.75 9.1 9.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PulG PF11773.8 KOO32502.1 - 0.5 10.2 3.4 0.92 9.4 3.4 1.3 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin YscO PF07321.12 KOO32502.1 - 0.51 10.3 13.4 1.1 9.3 13.4 1.5 1 0 0 1 1 1 0 Type III secretion protein YscO DUF3584 PF12128.8 KOO32502.1 - 3.3 5.1 6.2 4.5 4.6 6.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Pkinase PF00069.25 KOO32503.1 - 1.1e-22 80.7 0.0 8.9e-22 77.7 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32503.1 - 4.1e-05 23.0 0.0 8.3e-05 22.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO32503.1 - 0.014 14.7 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GlgX_C PF18390.1 KOO32503.1 - 0.043 13.6 0.0 0.16 11.8 0.0 1.9 1 0 0 1 1 1 0 Glycogen debranching enzyme C-terminal domain Kinase-like PF14531.6 KOO32503.1 - 0.092 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 KOO32503.1 - 1.1 9.2 10.2 0.067 13.1 0.8 2.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family Zeta_toxin PF06414.12 KOO32504.1 - 6.1e-24 84.4 0.0 1.1e-23 83.6 0.0 1.4 1 1 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 KOO32504.1 - 1.7e-09 38.0 0.4 2.6e-09 37.4 0.4 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO32504.1 - 0.00036 21.1 0.0 0.00068 20.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 KOO32504.1 - 0.00094 19.1 0.1 0.0015 18.4 0.1 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Kinesin PF00225.23 KOO32504.1 - 0.051 12.5 0.0 0.11 11.4 0.0 1.5 1 1 0 1 1 1 0 Kinesin motor domain APS_kinase PF01583.20 KOO32504.1 - 0.065 13.1 0.0 0.11 12.4 0.0 1.5 1 1 0 1 1 1 0 Adenylylsulphate kinase Microtub_bd PF16796.5 KOO32504.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Microtubule binding IstB_IS21 PF01695.17 KOO32504.1 - 0.16 11.7 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Metal_resist PF13801.6 KOO32505.1 - 0.0055 16.9 1.4 0.0055 16.9 1.4 3.1 3 1 0 3 3 3 1 Heavy-metal resistance UPF0242 PF06785.11 KOO32505.1 - 0.063 13.4 5.1 0.089 12.9 5.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF447 PF04289.12 KOO32505.1 - 0.096 12.5 0.7 0.15 11.8 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF447) adh_short_C2 PF13561.6 KOO32506.1 - 0.1 12.1 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase PRP1_N PF06424.12 KOO32507.1 - 2.1e-47 161.2 2.3 5.3e-47 159.9 2.3 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 KOO32507.1 - 9.3e-26 88.3 45.7 0.012 16.3 0.7 15.2 5 4 10 15 15 15 12 Tetratricopeptide repeat TPR_19 PF14559.6 KOO32507.1 - 1.9e-15 57.1 17.7 0.0007 20.1 0.2 9.6 7 4 2 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO32507.1 - 1.7e-05 24.7 1.0 3.5 8.1 0.0 7.4 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO32507.1 - 0.0028 17.9 0.2 27 5.4 0.0 5.9 5 0 0 5 5 5 0 Tetratricopeptide repeat ZNRF_3_ecto PF18212.1 KOO32507.1 - 0.0053 16.7 0.4 0.27 11.2 0.0 3.4 3 0 0 3 3 3 1 ZNRF-3 Ectodomain Suf PF05843.14 KOO32507.1 - 0.0055 16.7 0.4 2.7 7.9 0.0 3.8 4 0 0 4 4 4 1 Suppressor of forked protein (Suf) TPR_16 PF13432.6 KOO32507.1 - 0.006 17.2 37.4 2.9 8.6 2.2 8.8 7 3 3 10 10 10 3 Tetratricopeptide repeat NolX PF05819.11 KOO32507.1 - 0.055 12.8 0.4 1 8.6 0.0 2.2 2 0 0 2 2 2 0 NolX protein Sec2p PF06428.11 KOO32507.1 - 0.14 12.1 1.3 0.61 10.1 1.3 2.1 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p TPR_2 PF07719.17 KOO32507.1 - 0.82 9.9 12.9 9.5 6.6 0.0 7.4 9 0 0 9 9 9 0 Tetratricopeptide repeat SRP54 PF00448.22 KOO32508.1 - 4.3e-54 183.1 0.0 7.1e-54 182.4 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 KOO32508.1 - 1.8e-42 146.3 0.0 2.3e-42 145.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal MeaB PF03308.16 KOO32508.1 - 2.4e-06 26.8 0.1 1.3e-05 24.4 0.0 2.1 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54_N PF02881.19 KOO32508.1 - 4e-05 23.8 0.1 0.00014 22.0 0.0 2.0 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain AAA_16 PF13191.6 KOO32508.1 - 0.00013 22.4 0.0 0.00049 20.5 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 KOO32508.1 - 0.00021 21.1 0.0 0.0004 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOO32508.1 - 0.0005 20.4 0.0 0.02 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 KOO32508.1 - 0.014 15.3 0.0 0.48 10.3 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA PF00004.29 KOO32508.1 - 0.043 14.2 0.0 0.31 11.5 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 KOO32508.1 - 0.053 13.6 0.5 0.62 10.2 0.5 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase Peptidase_M14 PF00246.24 KOO32509.1 - 2.2e-30 106.4 0.0 3.1e-30 106.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase BRE1 PF08647.11 KOO32511.1 - 0.012 15.6 5.2 0.012 15.6 5.2 6.1 3 2 4 7 7 7 0 BRE1 E3 ubiquitin ligase SHE3 PF17078.5 KOO32511.1 - 5 6.8 23.7 0.024 14.3 6.7 3.3 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 FAD_binding_4 PF01565.23 KOO32512.1 - 2.7e-13 49.9 0.6 4.8e-13 49.0 0.6 1.5 1 1 0 1 1 1 1 FAD binding domain Spc7 PF08317.11 KOO32513.1 - 0.00036 19.5 5.4 0.00036 19.5 5.4 6.1 1 1 5 7 7 7 2 Spc7 kinetochore protein Zn_peptidase_2 PF04298.12 KOO32514.1 - 0.037 13.4 0.0 0.043 13.2 0.0 1.1 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase eIF-3_zeta PF05091.12 KOO32515.1 - 7.3e-165 549.9 0.0 5.6e-164 547.0 0.0 1.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 KOO32515.1 - 0.0013 18.3 0.0 0.0031 17.1 0.0 1.6 1 1 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus DUF569 PF04601.13 KOO32515.1 - 0.12 12.1 0.1 0.33 10.6 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF569) Na_sulph_symp PF00939.19 KOO32516.1 - 0.017 14.2 4.0 0.25 10.3 0.3 2.3 2 0 0 2 2 2 0 Sodium:sulfate symporter transmembrane region DEAD PF00270.29 KOO32517.1 - 1.3e-07 31.6 0.1 2.1e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO32517.1 - 0.044 13.8 0.0 0.096 12.7 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Dus PF01207.17 KOO32518.1 - 1.5e-61 208.2 0.0 2.7e-61 207.4 0.0 1.4 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) ThiG PF05690.14 KOO32518.1 - 1.2e-05 24.8 0.2 2.2e-05 23.9 0.2 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG NMO PF03060.15 KOO32518.1 - 1.3e-05 24.7 1.1 2.3e-05 24.0 1.1 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 KOO32518.1 - 8.9e-05 22.1 0.0 0.00019 21.0 0.0 1.5 2 0 0 2 2 2 1 Histidine biosynthesis protein SOR_SNZ PF01680.17 KOO32518.1 - 0.0037 17.1 0.2 0.034 13.9 0.2 2.1 2 0 0 2 2 2 1 SOR/SNZ family BKACE PF05853.12 KOO32518.1 - 0.004 16.5 0.3 0.0065 15.8 0.3 1.4 1 0 0 1 1 1 1 beta-keto acid cleavage enzyme DHO_dh PF01180.21 KOO32518.1 - 0.0048 16.1 0.0 0.021 14.1 0.1 1.8 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase TMP-TENI PF02581.17 KOO32518.1 - 0.01 15.2 0.4 0.019 14.3 0.4 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase IMPDH PF00478.25 KOO32518.1 - 0.022 13.8 0.9 0.033 13.2 0.9 1.2 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain G3P_antiterm PF04309.12 KOO32518.1 - 0.12 11.8 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator Pkinase PF00069.25 KOO32520.1 - 2.1e-57 194.5 0.0 2.7e-57 194.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32520.1 - 1.1e-23 83.9 0.0 1.6e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DSPc PF00782.20 KOO32520.1 - 7.5e-18 64.6 0.0 1.8e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Kinase-like PF14531.6 KOO32520.1 - 0.00078 18.8 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO32520.1 - 0.0078 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO32520.1 - 0.009 16.0 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOO32520.1 - 0.051 13.2 0.2 0.2 11.2 0.1 1.8 1 1 0 2 2 2 0 Choline/ethanolamine kinase UDPG_MGDP_dh_N PF03721.14 KOO32521.1 - 3.1e-57 193.2 0.0 4.4e-57 192.7 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 KOO32521.1 - 3.6e-34 117.3 0.1 2e-33 114.9 0.0 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 KOO32521.1 - 9.7e-32 109.0 0.0 2.9e-31 107.5 0.0 1.9 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Sacchrp_dh_NADP PF03435.18 KOO32521.1 - 0.098 12.9 0.0 0.47 10.7 0.0 2.2 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Glyco_hydro_3_C PF01915.22 KOO32521.1 - 0.15 12.0 0.1 0.26 11.2 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain DUF4262 PF14081.6 KOO32522.1 - 0.088 13.0 0.0 7.1 6.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4262) TPR_1 PF00515.28 KOO32523.1 - 7.9e-39 129.9 31.3 4.8e-07 29.3 0.5 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.17 KOO32523.1 - 6.2e-27 91.5 39.4 0.00025 20.9 0.2 9.1 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 KOO32523.1 - 1.2e-11 43.8 23.6 0.047 13.9 0.3 7.6 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOO32523.1 - 1.1e-10 41.7 38.7 5.7e-07 29.7 2.7 6.2 5 1 1 6 6 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO32523.1 - 1.6e-10 40.6 17.7 0.0044 17.3 1.2 7.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO32523.1 - 7.7e-10 38.3 21.4 0.00044 19.9 0.2 6.2 6 1 1 7 7 7 3 TPR repeat RPAP3_C PF13877.6 KOO32523.1 - 2.4e-08 34.4 0.0 7.5e-08 32.8 0.0 1.9 2 0 0 2 2 1 1 Potential Monad-binding region of RPAP3 TPR_19 PF14559.6 KOO32523.1 - 3.9e-08 33.7 24.6 0.023 15.2 3.4 5.9 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO32523.1 - 3.1e-07 30.0 20.1 0.033 14.2 0.0 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO32523.1 - 1e-06 29.0 21.2 3 8.7 0.2 8.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO32523.1 - 6.3e-06 26.2 24.4 0.043 14.0 4.4 5.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO32523.1 - 2e-05 25.2 57.2 0.014 16.1 7.1 7.6 8 1 0 8 8 5 4 Tetratricopeptide repeat DTHCT PF08070.11 KOO32523.1 - 4.5e-05 24.1 30.1 0.0027 18.4 5.9 4.4 2 1 1 3 3 3 2 DTHCT (NUC029) region TPR_14 PF13428.6 KOO32523.1 - 0.0036 18.0 40.0 0.012 16.4 0.2 7.5 6 2 2 8 8 6 4 Tetratricopeptide repeat TPR_3 PF07720.12 KOO32523.1 - 0.022 14.7 0.5 0.091 12.8 0.2 2.2 2 0 0 2 2 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO32523.1 - 0.056 13.7 23.9 0.33 11.2 0.1 4.7 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KOO32523.1 - 0.091 12.7 28.7 4.4 7.3 0.1 6.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO32523.1 - 0.54 10.4 14.1 0.93 9.6 0.0 4.8 5 1 1 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat SPO22 PF08631.10 KOO32523.1 - 4.8 6.6 9.8 10 5.5 0.9 3.4 3 1 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like RNase_T PF00929.24 KOO32524.1 - 0.0088 16.6 0.0 0.065 13.8 0.0 2.0 1 1 0 1 1 1 1 Exonuclease SPX PF03105.19 KOO32525.1 - 6.8e-05 23.0 1.1 0.036 14.0 0.1 2.1 2 0 0 2 2 2 2 SPX domain AAA PF00004.29 KOO32526.1 - 1.8e-34 119.0 0.0 3e-34 118.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO32526.1 - 9.8e-10 38.1 4.6 9.8e-10 38.1 4.6 2.0 2 0 0 2 2 1 1 AAA+ lid domain RuvB_N PF05496.12 KOO32526.1 - 2.5e-05 24.1 0.0 6.2e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO32526.1 - 6e-05 23.5 6.5 0.00013 22.3 0.0 3.3 1 1 2 3 3 3 1 AAA ATPase domain TIP49 PF06068.13 KOO32526.1 - 8.9e-05 21.8 0.0 0.00037 19.8 0.0 1.8 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 KOO32526.1 - 0.00016 21.9 0.0 0.0014 18.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO32526.1 - 0.00037 20.5 0.0 0.0022 18.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KOO32526.1 - 0.00042 20.1 0.0 0.00068 19.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 KOO32526.1 - 0.0011 19.1 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOO32526.1 - 0.0017 18.1 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 KOO32526.1 - 0.0034 17.3 0.0 0.097 12.6 0.0 2.5 1 1 1 2 2 2 1 NACHT domain Sigma54_activat PF00158.26 KOO32526.1 - 0.0035 17.1 0.0 0.015 15.0 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.6 KOO32526.1 - 0.0056 17.2 0.0 0.015 15.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain AFG1_ATPase PF03969.16 KOO32526.1 - 0.012 14.6 0.1 0.43 9.4 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase TsaE PF02367.17 KOO32526.1 - 0.013 15.5 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KOO32526.1 - 0.013 15.5 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KOO32526.1 - 0.02 14.3 0.1 0.04 13.3 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 KOO32526.1 - 0.027 14.3 0.0 0.046 13.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOO32526.1 - 0.032 13.9 3.1 0.61 9.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_2 PF07724.14 KOO32526.1 - 0.045 13.9 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 KOO32526.1 - 0.05 14.0 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 KOO32526.1 - 0.058 13.6 1.3 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 KOO32526.1 - 0.062 12.7 0.0 7.7 5.9 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein Zeta_toxin PF06414.12 KOO32526.1 - 0.064 12.5 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 KOO32526.1 - 0.073 12.8 0.0 0.37 10.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 KOO32526.1 - 0.074 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 KOO32526.1 - 0.12 11.9 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 KOO32526.1 - 0.15 11.9 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 KOO32526.1 - 0.18 11.2 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein NB-ARC PF00931.22 KOO32526.1 - 0.21 10.8 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain DUF2075 PF09848.9 KOO32526.1 - 0.28 10.4 0.0 0.39 9.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Hydin_ADK PF17213.3 KOO32526.1 - 0.43 10.8 3.9 2.8 8.2 0.1 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain ISN1 PF06437.11 KOO32527.1 - 8.2e-85 285.2 0.0 9.4e-85 285.0 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Hydrolase_3 PF08282.12 KOO32527.1 - 0.11 12.3 0.0 6.2 6.5 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase SAP PF02037.27 KOO32527.1 - 0.43 10.4 1.5 2.4 8.0 0.2 2.5 2 0 0 2 2 2 0 SAP domain DHC_N1 PF08385.12 KOO32528.1 - 2.3e-160 535.0 17.2 5.4e-160 533.7 17.2 1.7 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 BACK PF07707.15 KOO32528.1 - 0.058 13.5 2.6 0.066 13.3 0.5 2.2 2 0 0 2 2 2 0 BTB And C-terminal Kelch SbsC_C PF18058.1 KOO32528.1 - 1.1 9.5 0.0 1.1 9.5 0.0 3.8 5 1 1 6 6 6 0 SbsC C-terminal domain Na_sulph_symp PF00939.19 KOO32529.1 - 4.2e-09 36.0 7.3 5e-09 35.7 7.3 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KOO32529.1 - 2.7e-07 30.1 8.7 2.7e-07 30.1 8.7 1.4 1 1 1 2 2 2 2 Citrate transporter CitMHS PF03600.16 KOO32530.1 - 7.5e-21 74.6 2.5 7.5e-21 74.6 2.5 1.8 2 0 0 2 2 2 1 Citrate transporter Methyltransf_10 PF05971.12 KOO32531.1 - 4.2e-78 262.7 0.0 5.5e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 KOO32531.1 - 0.0054 16.3 0.0 0.0086 15.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ank_2 PF12796.7 KOO32532.1 - 3.6e-17 62.7 1.6 2.2e-06 28.1 0.2 3.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO32532.1 - 7.5e-13 47.4 4.3 0.00023 21.3 0.1 5.9 6 0 0 6 6 5 3 Ankyrin repeat Ank_5 PF13857.6 KOO32532.1 - 3.3e-10 40.0 2.5 0.00022 21.5 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeats (many copies) EF-hand_7 PF13499.6 KOO32532.1 - 1e-09 38.7 0.0 4.8e-09 36.5 0.0 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO32532.1 - 1.9e-09 36.7 0.2 8.7e-05 22.2 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO32532.1 - 3.6e-09 35.5 0.1 3.6e-05 23.0 0.0 3.0 2 0 0 2 2 2 2 EF hand Ank PF00023.30 KOO32532.1 - 1.6e-08 34.6 2.7 0.0045 17.4 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat ART PF01129.18 KOO32532.1 - 2.2e-07 30.4 0.0 2.2e-07 30.4 0.0 2.3 2 0 0 2 2 1 1 NAD:arginine ADP-ribosyltransferase Ank_4 PF13637.6 KOO32532.1 - 7.8e-06 26.3 1.7 0.06 13.9 0.2 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) EF-hand_5 PF13202.6 KOO32532.1 - 0.00014 21.2 0.1 0.015 14.8 0.0 2.9 2 0 0 2 2 2 1 EF hand GrpE PF01025.19 KOO32532.1 - 0.0031 17.2 7.0 0.0031 17.2 7.0 2.9 2 0 0 2 2 2 1 GrpE EF-hand_8 PF13833.6 KOO32532.1 - 0.017 15.0 0.1 0.3 11.0 0.0 2.8 1 1 1 2 2 2 0 EF-hand domain pair Arm PF00514.23 KOO32534.1 - 5.5e-05 23.1 11.7 0.11 12.6 0.1 6.0 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KOO32534.1 - 0.0006 19.8 16.8 1.5 9.3 0.1 6.7 6 2 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 KOO32534.1 - 0.0022 18.4 13.5 1.5 9.4 0.5 6.2 6 2 1 7 7 7 2 HEAT-like repeat PK_C PF02887.16 KOO32534.1 - 0.017 15.3 0.1 0.14 12.4 0.0 2.2 2 0 0 2 2 2 0 Pyruvate kinase, alpha/beta domain IFRD PF05004.13 KOO32534.1 - 0.024 13.8 0.5 0.064 12.4 0.3 1.8 1 1 0 1 1 1 0 Interferon-related developmental regulator (IFRD) Cnd1 PF12717.7 KOO32534.1 - 0.14 12.2 0.2 1.2 9.2 0.1 2.1 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 EF-hand_1 PF00036.32 KOO32535.1 - 3.6e-11 41.8 2.4 5.5e-05 22.4 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO32535.1 - 2.9e-10 39.2 3.5 0.00046 19.9 0.5 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO32535.1 - 4.5e-09 35.4 2.2 4.5e-05 22.8 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO32535.1 - 2.1e-08 34.5 0.9 0.0042 17.5 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO32535.1 - 0.00011 22.0 0.3 0.041 13.7 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair PEP-utilisers_N PF05524.13 KOO32535.1 - 3 8.0 7.1 12 6.1 0.0 2.8 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal RRM_1 PF00076.22 KOO32536.1 - 4.5e-22 77.6 0.0 2.6e-09 36.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KOO32536.1 - 0.01 15.9 0.0 0.031 14.3 0.0 1.8 2 0 0 2 2 2 1 RNA binding motif RRM_5 PF13893.6 KOO32536.1 - 0.013 15.1 0.0 0.053 13.1 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 KOO32536.1 - 0.026 14.4 0.0 0.67 9.8 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) Keratin_2_head PF16208.5 KOO32536.1 - 1.1 9.4 31.9 2 8.6 15.6 2.5 2 0 0 2 2 2 0 Keratin type II head rve PF00665.26 KOO32538.1 - 9.3e-13 48.4 0.0 2e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Nuc_rec_co-act PF08815.10 KOO32538.1 - 0.14 12.0 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Nuclear receptor coactivator RVT_2 PF07727.14 KOO32540.1 - 5e-30 104.9 0.0 8.4e-30 104.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KOO32540.1 - 8.6e-13 48.5 0.0 1.8e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain LRR_4 PF12799.7 KOO32541.1 - 4.1e-17 62.0 26.2 0.00025 21.4 0.0 7.6 1 1 7 10 10 10 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO32541.1 - 9.1e-17 60.6 21.5 0.0027 17.4 2.1 5.9 2 2 4 6 6 6 6 Leucine rich repeat ADPrib_exo_Tox PF03496.14 KOO32541.1 - 0.0027 17.1 0.0 0.0061 15.9 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO32541.1 - 0.1 11.9 0.0 0.25 10.6 0.0 1.6 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase Attacin_N PF03768.15 KOO32541.1 - 0.6 10.3 4.8 2.5 8.3 4.8 2.0 1 0 0 1 1 1 0 Attacin, N-terminal region LRR_1 PF00560.33 KOO32541.1 - 0.62 10.8 26.5 52 5.0 0.0 9.5 10 1 0 10 10 10 0 Leucine Rich Repeat U-box PF04564.15 KOO32544.1 - 1.5e-13 50.7 0.0 2.6e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO32544.1 - 2.8e-06 27.8 0.5 6.4e-06 26.7 0.5 1.7 1 0 0 1 1 1 1 Sel1 repeat zf-NOSIP PF15906.5 KOO32544.1 - 0.00012 22.1 0.0 0.0004 20.4 0.0 1.7 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO32544.1 - 0.0019 17.9 0.0 0.0058 16.4 0.0 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Glyco_transf_90 PF05686.12 KOO32546.1 - 2.2e-25 89.4 0.0 4.3e-25 88.5 0.0 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 90 Pre-PUA PF17832.1 KOO32546.1 - 0.0036 17.9 0.0 0.0064 17.2 0.0 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain Glyco_trans_1_2 PF13524.6 KOO32546.1 - 0.15 12.5 0.0 0.31 11.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Ank_2 PF12796.7 KOO32547.1 - 3e-56 187.9 12.6 4.1e-13 49.7 1.7 7.3 2 1 7 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO32547.1 - 4.1e-52 173.9 3.5 2.1e-07 31.3 0.0 10.6 6 3 4 10 10 10 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO32547.1 - 2.7e-31 107.2 9.3 4.2e-05 23.7 0.1 9.3 7 2 1 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO32547.1 - 1.2e-25 86.7 12.5 0.015 15.8 0.0 14.0 14 0 0 14 14 14 4 Ankyrin repeat Ank PF00023.30 KOO32547.1 - 2.3e-25 87.9 19.5 0.009 16.4 0.1 13.1 13 0 0 13 13 13 6 Ankyrin repeat PUB PF09409.10 KOO32547.1 - 3.2e-14 52.6 0.0 7.9e-14 51.4 0.0 1.6 1 0 0 1 1 1 1 PUB domain SH3_15 PF18346.1 KOO32547.1 - 3.5e-07 30.5 1.1 1.1e-06 28.9 0.3 2.4 2 0 0 2 2 2 1 Mind bomb SH3 repeat domain SAM_1 PF00536.30 KOO32547.1 - 2.3e-06 28.0 0.3 0.015 15.7 0.0 2.9 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) ResIII PF04851.15 KOO32547.1 - 2.9e-06 27.4 0.0 3.2e-05 24.0 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SAM_2 PF07647.17 KOO32547.1 - 0.00013 22.0 0.1 0.026 14.6 0.0 3.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) ADPrib_exo_Tox PF03496.14 KOO32547.1 - 0.00024 20.5 0.0 0.027 13.8 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosyltransferase exoenzyme DEAD PF00270.29 KOO32547.1 - 0.022 14.5 0.0 0.089 12.6 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_12 PF13087.6 KOO32547.1 - 0.17 11.5 0.0 0.36 10.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain IQ PF00612.27 KOO32547.1 - 0.28 11.1 3.0 0.83 9.6 3.0 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Filamin PF00630.19 KOO32548.1 - 1.1e-14 55.0 0.0 0.00016 22.5 0.0 4.1 2 1 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO32548.1 - 2e-05 24.8 0.0 0.0009 19.5 0.0 3.3 3 1 0 3 3 3 1 Invasin, domain 3 Ank_2 PF12796.7 KOO32549.1 - 0.00073 20.1 0.0 0.072 13.7 0.0 2.6 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) CHAT PF12770.7 KOO32549.1 - 0.014 14.8 0.1 0.026 13.9 0.1 1.4 1 0 0 1 1 1 0 CHAT domain Ank_5 PF13857.6 KOO32549.1 - 0.14 12.5 0.1 2.6 8.5 0.0 3.0 2 1 1 3 3 3 0 Ankyrin repeats (many copies) UIM PF02809.20 KOO32549.1 - 0.39 10.7 4.3 1.5 8.9 4.3 2.1 1 0 0 1 1 1 0 Ubiquitin interaction motif Metallophos PF00149.28 KOO32550.1 - 0.00082 19.9 0.0 0.0011 19.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Alpha_kinase PF02816.18 KOO32551.1 - 2e-29 103.0 0.0 3.8e-29 102.1 0.0 1.3 1 0 0 1 1 1 1 Alpha-kinase family Shugoshin_N PF07558.11 KOO32551.1 - 6.8e-05 22.6 2.6 4.5 7.2 0.1 4.4 4 0 0 4 4 4 3 Shugoshin N-terminal coiled-coil region VWA_2 PF13519.6 KOO32551.1 - 0.0012 19.5 0.0 0.0012 19.5 0.0 2.8 3 1 0 3 3 3 1 von Willebrand factor type A domain VWA PF00092.28 KOO32551.1 - 0.0021 18.3 0.0 0.0062 16.8 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain TssR PF17643.1 KOO32551.1 - 0.025 12.5 0.0 0.042 11.8 0.0 1.3 1 1 0 1 1 1 0 Type VI secretion system, TssR Med25_VWA PF11265.8 KOO32551.1 - 0.027 14.3 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Mediator complex subunit 25 von Willebrand factor type A DUF3349 PF11829.8 KOO32551.1 - 1 10.2 3.4 1.4 9.8 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3349) Ribosomal_L13e PF01294.18 KOO32552.1 - 9.6e-06 25.6 4.8 0.17 11.8 0.1 3.6 1 1 2 3 3 3 3 Ribosomal protein L13e RPAP1_C PF08620.10 KOO32552.1 - 0.00029 20.9 7.9 4.9 7.3 0.2 5.4 2 2 3 5 5 5 2 RPAP1-like, C-terminal CelD_N PF02927.14 KOO32552.1 - 0.097 13.6 0.9 19 6.2 0.2 2.8 1 1 2 3 3 3 0 Cellulase N-terminal ig-like domain SinI PF08671.10 KOO32552.1 - 0.18 11.7 0.2 34 4.4 0.0 3.0 3 0 0 3 3 3 0 Anti-repressor SinI Rhabdo_glycop PF00974.18 KOO32552.1 - 0.18 10.2 0.1 1.1 7.7 0.0 1.9 1 1 1 2 2 2 0 Rhabdovirus spike glycoprotein Pyr_redox_dim PF02852.22 KOO32552.1 - 0.41 10.9 6.3 18 5.6 0.2 3.1 1 1 2 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain AAA_lid_3 PF17862.1 KOO32552.1 - 0.74 9.7 6.6 13 5.7 0.9 3.9 2 1 0 3 3 3 0 AAA+ lid domain Sigma70_r4_2 PF08281.12 KOO32553.1 - 0.00046 19.8 10.6 42 3.9 0.0 9.1 4 2 3 10 10 10 0 Sigma-70, region 4 DUF1289 PF06945.13 KOO32553.1 - 0.00069 19.4 49.0 7.6 6.4 0.2 11.4 4 1 9 14 14 14 9 Protein of unknown function (DUF1289) DUF2299 PF10061.9 KOO32553.1 - 0.014 15.1 14.5 7.8 6.2 0.1 6.7 1 1 4 7 7 7 0 Uncharacterized conserved protein (DUF2299) DUF4473 PF14747.6 KOO32553.1 - 0.06 13.9 52.5 0.1 13.1 2.0 8.0 3 2 4 8 8 8 0 Domain of unknown function (DUF4473) YjbR PF04237.13 KOO32553.1 - 1.8 9.2 12.1 1.8e+02 2.8 0.1 5.2 1 1 1 2 2 2 0 YjbR Pkinase PF00069.25 KOO32554.1 - 1.8e-43 148.8 0.0 1.7e-42 145.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32554.1 - 2.1e-28 99.3 0.0 3.5e-25 88.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOO32554.1 - 9.2e-10 38.3 0.0 0.0005 19.5 0.0 3.0 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 KOO32554.1 - 0.017 13.9 0.0 0.032 13.0 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase ABC1 PF03109.16 KOO32554.1 - 0.031 14.4 0.0 0.07 13.3 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Kdo PF06293.14 KOO32554.1 - 0.15 11.4 0.2 0.27 10.6 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Med3 PF11593.8 KOO32554.1 - 0.45 9.6 4.1 0.77 8.9 4.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal APH PF01636.23 KOO32554.1 - 1.7 8.5 5.7 7.2 6.5 5.7 2.2 1 1 0 1 1 1 0 Phosphotransferase enzyme family FAM199X PF15814.5 KOO32554.1 - 2 7.4 5.5 3.4 6.6 5.5 1.3 1 0 0 1 1 1 0 Protein family FAM199X Pkinase_Tyr PF07714.17 KOO32555.1 - 2.5e-21 76.2 0.0 3.6e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO32555.1 - 6.9e-21 74.8 0.0 9.2e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO32555.1 - 0.004 17.1 3.4 0.012 15.5 0.3 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family zf-trcl PF13451.6 KOO32558.1 - 1.5e-13 50.4 1.5 1.5e-13 50.4 1.5 2.4 2 1 0 2 2 2 1 Probable zinc-ribbon domain SART-1 PF03343.13 KOO32560.1 - 0.25 9.9 3.5 0.29 9.6 3.5 1.0 1 0 0 1 1 1 0 SART-1 family adh_short PF00106.25 KOO32561.1 - 3.2e-13 49.6 0.0 4e-10 39.5 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase DEAD PF00270.29 KOO32562.1 - 2.2e-50 170.9 0.0 5.2e-50 169.6 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO32562.1 - 3.6e-33 114.2 0.0 2.8e-31 108.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO32562.1 - 0.00011 22.2 0.0 0.00044 20.3 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOO32562.1 - 0.0031 16.8 0.0 0.0045 16.2 0.0 1.1 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 KOO32562.1 - 0.063 13.5 0.0 0.66 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain SMC_hinge PF06470.13 KOO32563.1 - 2.5e-24 85.8 0.0 7.9e-24 84.2 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.19 KOO32563.1 - 1.9e-20 73.3 24.6 2.4e-20 72.9 24.6 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 KOO32563.1 - 2e-06 27.8 5.2 2e-06 27.8 5.2 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 KOO32563.1 - 5.8e-06 26.0 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 KOO32563.1 - 2.1e-05 24.5 0.0 6.6e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 KOO32563.1 - 0.84 10.2 0.0 0.84 10.2 0.0 5.5 3 2 0 3 3 3 0 ABC transporter Epimerase PF01370.21 KOO32564.1 - 1.2e-41 142.8 0.0 1.8e-41 142.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO32564.1 - 3.2e-38 131.9 0.0 4.8e-38 131.4 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 KOO32564.1 - 3.7e-11 42.6 0.0 1.1e-09 37.8 0.0 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KOO32564.1 - 2.7e-10 39.8 0.0 4.2e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KOO32564.1 - 7.9e-10 38.3 0.0 4.5e-09 35.9 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_8 PF13450.6 KOO32564.1 - 7.7e-09 35.7 1.3 1.6e-05 25.0 0.0 3.7 4 0 0 4 4 3 2 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KOO32564.1 - 2.4e-07 30.4 0.0 1.5e-06 27.8 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 KOO32564.1 - 4.9e-05 22.7 0.0 0.058 12.6 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_10 PF13460.6 KOO32564.1 - 0.00025 21.0 0.0 0.00061 19.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)H-binding DAO PF01266.24 KOO32564.1 - 0.00035 20.3 3.3 0.026 14.1 0.2 3.1 4 0 0 4 4 4 1 FAD dependent oxidoreductase Sacchrp_dh_NADP PF03435.18 KOO32564.1 - 0.0013 19.0 0.6 0.011 16.0 0.1 2.4 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 KOO32564.1 - 0.0018 17.8 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase DUF3431 PF11913.8 KOO32564.1 - 0.0024 17.7 0.0 0.073 12.8 0.0 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) KR PF08659.10 KOO32564.1 - 0.0046 16.9 0.0 0.0083 16.0 0.0 1.4 1 0 0 1 1 1 1 KR domain Pyr_redox PF00070.27 KOO32564.1 - 0.0058 17.2 1.8 1.5 9.4 0.0 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FLgD_tudor PF13861.6 KOO32564.1 - 0.0068 16.6 0.2 0.021 15.1 0.0 1.9 2 0 0 2 2 1 1 FlgD Tudor-like domain NmrA PF05368.13 KOO32564.1 - 0.016 14.8 0.1 0.028 14.0 0.1 1.4 1 0 0 1 1 1 0 NmrA-like family FAD_binding_2 PF00890.24 KOO32564.1 - 0.041 13.0 0.0 0.091 11.8 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain FAD_binding_3 PF01494.19 KOO32564.1 - 0.13 11.5 0.6 0.34 10.1 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 KOO32564.1 - 0.14 12.1 2.9 4.8 7.1 0.0 3.4 4 0 0 4 4 3 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 KOO32564.1 - 0.16 11.2 0.0 0.27 10.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UBA_4 PF14555.6 KOO32565.1 - 5.4e-10 38.9 0.0 1.1e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain WD40 PF00400.32 KOO32566.1 - 1.6e-20 73.1 17.5 0.003 18.4 0.0 7.5 8 0 0 8 8 8 5 WD domain, G-beta repeat SPRY PF00622.28 KOO32566.1 - 0.055 13.6 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 SPRY domain Aldose_epim PF01263.20 KOO32567.1 - 2.9e-28 99.0 0.0 6.1e-28 98.0 0.0 1.4 1 1 0 1 1 1 1 Aldose 1-epimerase ABATE PF07336.11 KOO32568.1 - 0.00029 21.5 0.9 0.17 12.5 0.0 2.8 2 0 0 2 2 2 2 Putative stress-induced transcription regulator HrpB7 PF09486.10 KOO32568.1 - 0.39 11.1 5.7 0.17 12.3 2.2 2.2 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Arm PF00514.23 KOO32569.1 - 1.5e-127 412.3 92.9 2.1e-06 27.6 0.1 34.2 35 0 0 35 35 35 25 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO32569.1 - 8.5e-22 77.0 3.6 0.01 15.9 0.0 12.7 10 1 4 14 14 14 4 Spinocerebellar ataxia type 10 protein domain DUF5578 PF17741.1 KOO32569.1 - 1.1e-21 77.5 16.1 0.00012 21.6 0.0 9.6 5 3 3 10 10 10 4 Family of unknown function (DUF5578) Cnd1 PF12717.7 KOO32569.1 - 2.1e-12 47.4 0.0 0.023 14.7 0.1 8.6 8 1 0 8 8 8 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 KOO32569.1 - 2.9e-11 43.2 3.1 0.0074 15.6 0.8 6.8 3 2 2 5 5 5 2 V-ATPase subunit H HEAT_2 PF13646.6 KOO32569.1 - 1.5e-09 38.1 70.1 1.8e-06 28.2 2.5 13.8 9 4 6 16 16 16 4 HEAT repeats Arm_2 PF04826.13 KOO32569.1 - 8.8e-09 35.2 3.2 0.82 9.1 0.0 8.3 8 2 1 10 10 10 1 Armadillo-like RICTOR_N PF14664.6 KOO32569.1 - 2.7e-08 33.2 4.6 0.32 10.0 0.0 8.1 6 2 3 9 9 9 2 Rapamycin-insensitive companion of mTOR, N-term Adaptin_N PF01602.20 KOO32569.1 - 1.3e-06 27.3 5.2 2.6 6.5 0.1 7.4 6 2 2 9 9 9 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 KOO32569.1 - 3.4e-06 27.2 0.1 1.9 8.6 0.0 6.6 7 1 1 8 8 8 1 V-ATPase subunit H HEAT_EZ PF13513.6 KOO32569.1 - 0.00018 22.0 6.5 0.0013 19.2 2.1 16.4 19 2 2 21 21 18 4 HEAT-like repeat RYDR_ITPR PF01365.21 KOO32569.1 - 0.002 17.6 0.2 1.4 8.3 0.0 3.5 3 0 0 3 3 3 1 RIH domain Peptidase_C26 PF07722.13 KOO32569.1 - 0.021 14.6 0.2 3 7.5 0.0 3.7 3 0 0 3 3 3 0 Peptidase C26 NopRA1 PF16201.5 KOO32569.1 - 0.66 9.5 4.4 0.6 9.6 0.0 3.3 4 0 0 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 MMS19_N PF14500.6 KOO32569.1 - 0.68 9.5 3.3 15 5.1 0.0 4.0 4 0 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.22 KOO32569.1 - 4.5 7.8 44.0 9.2 6.8 0.0 13.0 13 0 0 13 13 13 0 HEAT repeat WD40 PF00400.32 KOO32570.1 - 3.2e-05 24.6 2.0 0.4 11.6 0.0 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat NUC205 PF08168.11 KOO32570.1 - 0.28 10.7 0.8 0.67 9.5 0.8 1.6 1 0 0 1 1 1 0 NUC205 domain DUF5541 PF17695.1 KOO32571.1 - 0.071 13.5 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5541) EF-hand_6 PF13405.6 KOO32572.1 - 0.0056 16.5 0.1 0.012 15.4 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO32572.1 - 0.027 14.0 0.3 0.059 12.9 0.3 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO32572.1 - 0.077 13.5 0.3 0.21 12.1 0.2 1.7 1 1 1 2 2 2 0 EF-hand domain pair DUF3810 PF12725.7 KOO32572.1 - 0.12 11.8 0.2 0.17 11.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) PDZ_6 PF17820.1 KOO32573.1 - 5.6e-16 58.1 0.3 1.9e-08 34.0 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 KOO32573.1 - 2.7e-08 34.1 0.1 0.00018 21.8 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KOO32573.1 - 4.8e-07 30.0 0.1 0.0054 17.0 0.0 2.6 2 0 0 2 2 2 2 PDZ domain GP67 PF17634.2 KOO32573.1 - 0.052 14.0 9.7 0.15 12.5 9.7 1.8 1 0 0 1 1 1 0 Gene product 67 DNA_pol_phi PF04931.13 KOO32573.1 - 2.3 6.2 4.8 2.9 5.9 4.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi BPL_LplA_LipB PF03099.19 KOO32574.1 - 1.7e-10 40.9 0.0 2.4e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family EF-hand_1 PF00036.32 KOO32575.1 - 0.00017 20.9 0.2 0.00036 19.9 0.2 1.6 1 0 0 1 1 1 1 EF hand LRR_8 PF13855.6 KOO32575.1 - 0.0012 18.5 3.1 0.047 13.5 2.3 3.1 2 1 0 2 2 2 1 Leucine rich repeat EF-hand_8 PF13833.6 KOO32575.1 - 0.0025 17.6 0.1 0.0069 16.2 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO32575.1 - 0.0026 17.5 0.2 0.0066 16.3 0.2 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO32575.1 - 0.01 15.3 0.3 0.023 14.2 0.3 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO32575.1 - 0.024 15.1 0.1 0.062 13.8 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair PMI_typeI PF01238.21 KOO32576.1 - 9.4e-39 133.6 0.0 1.2e-38 133.3 0.0 1.2 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 KOO32576.1 - 0.023 14.6 0.5 22 5.0 0.0 3.5 3 1 0 4 4 4 0 AraC-like ligand binding domain 2OG-FeII_Oxy_3 PF13640.6 KOO32577.1 - 1.6e-11 44.9 0.0 9.9e-11 42.4 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SelR PF01641.18 KOO32578.1 - 1e-32 112.8 0.0 1.7e-32 112.0 0.0 1.3 1 1 0 1 1 1 1 SelR domain zf-ribbon_3 PF13248.6 KOO32578.1 - 0.00023 20.4 1.1 0.5 9.9 0.2 2.4 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 KOO32578.1 - 0.00032 20.7 0.1 0.00068 19.6 0.0 1.5 2 0 0 2 2 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 KOO32578.1 - 0.00075 19.1 4.0 0.051 13.3 0.1 2.5 2 0 0 2 2 2 2 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 KOO32578.1 - 0.0064 16.0 0.1 0.65 9.6 0.0 2.4 2 0 0 2 2 2 1 TFIIB zinc-binding GFA PF04828.14 KOO32578.1 - 0.026 14.9 0.0 2.8 8.3 0.0 2.5 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-RRN7 PF11781.8 KOO32578.1 - 0.066 12.9 0.9 2 8.2 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zinc_ribbon_10 PF10058.9 KOO32578.1 - 0.068 12.9 0.1 8.9 6.1 0.0 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-LITAF-like PF10601.9 KOO32578.1 - 0.079 13.2 0.1 9.6 6.6 0.2 2.3 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain Prim_Zn_Ribbon PF08273.12 KOO32578.1 - 0.11 12.8 0.8 2.3 8.6 0.1 2.3 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF678 PF05077.12 KOO32578.1 - 0.12 12.5 0.1 8.6 6.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF678) Nudix_N_2 PF14803.6 KOO32578.1 - 0.14 12.1 2.3 6.8 6.7 0.2 2.6 2 0 0 2 2 2 0 Nudix N-terminal zf-NADH-PPase PF09297.11 KOO32578.1 - 0.19 11.4 2.5 2 8.2 0.3 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain HscB_4_cys PF18256.1 KOO32578.1 - 0.27 11.1 1.7 17 5.3 0.1 2.6 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif Yippee-Mis18 PF03226.14 KOO32578.1 - 0.27 11.4 0.8 1.2 9.4 0.8 1.9 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF4440 PF14534.6 KOO32579.1 - 0.0019 18.5 0.1 0.0037 17.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 KOO32579.1 - 0.038 14.2 0.0 0.089 13.1 0.0 1.6 1 0 0 1 1 1 0 SnoaL-like domain Styelin PF17562.2 KOO32579.1 - 3.8 7.9 5.0 16 5.9 0.4 2.9 3 0 0 3 3 3 0 Styelin SBBP PF06739.11 KOO32580.1 - 1.8e-24 85.4 40.5 0.0005 20.0 0.8 7.3 7 0 0 7 7 7 7 Beta-propeller repeat Ponericin PF07442.11 KOO32580.1 - 0.9 9.6 4.7 1.9e+02 2.2 0.0 5.0 6 0 0 6 6 6 0 Ponericin Ku_PK_bind PF08785.11 KOO32582.1 - 5.6e-12 45.9 0.0 1.7e-11 44.3 0.0 1.9 2 0 0 2 2 2 1 Ku C terminal domain like Ku PF02735.16 KOO32582.1 - 3.4e-11 43.2 0.0 5.6e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 KOO32582.1 - 1.2e-10 41.6 0.0 1.8e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 KOO32582.1 - 1.1e-05 26.0 0.0 7.4e-05 23.4 0.0 2.5 1 1 0 1 1 1 1 Ku70/Ku80 C-terminal arm VWA PF00092.28 KOO32582.1 - 4.4e-05 23.8 0.0 0.17 12.1 0.0 2.6 3 0 0 3 3 3 2 von Willebrand factor type A domain GGDEF_2 PF17853.1 KOO32582.1 - 0.02 15.1 3.1 1.7 8.9 0.0 3.8 3 0 0 3 3 3 0 GGDEF-like domain VWA_2 PF13519.6 KOO32582.1 - 0.043 14.5 0.0 0.32 11.7 0.0 2.5 3 0 0 3 3 3 0 von Willebrand factor type A domain Ank_2 PF12796.7 KOO32584.1 - 1.8e-26 92.5 5.2 4.8e-10 39.9 0.1 4.3 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO32584.1 - 1.5e-23 82.9 3.1 1.4e-06 28.7 0.0 5.7 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO32584.1 - 7e-22 77.2 8.5 6.4e-08 32.7 0.6 4.2 3 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO32584.1 - 7.1e-16 57.9 7.1 0.0044 17.4 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 KOO32584.1 - 7.3e-15 53.6 3.3 0.053 14.1 0.0 6.7 7 0 0 7 7 7 5 Ankyrin repeat TraT PF05818.12 KOO32584.1 - 7.8 6.1 8.9 22 4.6 8.9 1.8 1 1 0 1 1 1 0 Enterobacterial TraT complement resistance protein EF-hand_6 PF13405.6 KOO32585.1 - 0.00032 20.4 0.2 0.0011 18.7 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO32585.1 - 0.0012 18.2 0.1 0.0038 16.7 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO32585.1 - 0.0052 16.2 0.3 0.013 15.0 0.3 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO32585.1 - 0.019 15.4 0.0 0.043 14.3 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair UPF0261 PF06792.11 KOO32586.1 - 0.02 13.8 0.1 0.039 12.9 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0261) DUF2796 PF10986.8 KOO32586.1 - 0.22 11.5 8.0 13 5.7 7.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) Dicty_REP PF05086.12 KOO32586.1 - 0.68 7.8 7.1 1 7.3 7.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein GCIP PF13324.6 KOO32586.1 - 1.1 8.8 9.6 2.9 7.4 9.6 1.7 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting LRR_4 PF12799.7 KOO32587.1 - 4.6e-14 52.3 0.1 7e-06 26.3 0.3 5.0 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO32587.1 - 8.7e-11 41.6 0.0 6.2e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KOO32587.1 - 2.6e-06 27.1 1.2 2.4 8.0 0.1 4.6 4 1 0 4 4 4 1 Leucine rich repeat LRR_1 PF00560.33 KOO32587.1 - 0.00022 21.3 0.1 13 6.8 0.0 5.4 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 KOO32587.1 - 0.027 14.5 6.2 14 6.1 0.1 5.4 6 0 0 6 6 6 0 Leucine Rich repeat Rrp15p PF07890.12 KOO32588.1 - 4e-20 72.5 3.7 5.3e-20 72.1 3.7 1.2 1 0 0 1 1 1 1 Rrp15p SAM_1 PF00536.30 KOO32589.1 - 7.6e-06 26.3 0.0 1.3e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) OmdA PF13376.6 KOO32589.1 - 0.093 12.8 0.4 0.19 11.7 0.4 1.6 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated SAM_2 PF07647.17 KOO32589.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) YrhK PF14145.6 KOO32590.1 - 1.2e-05 25.1 18.8 0.01 15.7 0.8 3.8 3 1 0 3 3 3 3 YrhK-like protein ART PF01129.18 KOO32590.1 - 0.00012 21.5 0.0 0.00022 20.6 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO32590.1 - 0.022 14.1 0.0 2.3 7.5 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosyltransferase exoenzyme Spc7 PF08317.11 KOO32591.1 - 0.00047 19.1 16.3 0.0027 16.6 3.6 2.1 1 1 1 2 2 2 2 Spc7 kinetochore protein Alpha-2-MRAP_C PF06401.11 KOO32591.1 - 0.0018 18.3 4.1 0.0052 16.8 3.7 1.8 1 1 1 2 2 2 1 Alpha-2-macroglobulin RAP, C-terminal domain Fib_alpha PF08702.10 KOO32591.1 - 0.0039 17.4 6.9 0.34 11.1 0.2 3.2 1 1 1 3 3 3 2 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.9 KOO32591.1 - 0.011 15.7 4.5 0.011 15.7 4.5 3.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CorA PF01544.18 KOO32591.1 - 0.02 14.2 0.6 0.02 14.2 0.6 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein COG2 PF06148.11 KOO32591.1 - 0.06 13.4 11.8 0.48 10.5 0.2 3.7 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 PelD_GGDEF PF16963.5 KOO32591.1 - 0.077 12.8 7.2 0.061 13.1 3.8 2.3 1 1 1 2 2 2 0 PelD GGDEF domain BLOC1_2 PF10046.9 KOO32591.1 - 0.089 13.1 5.3 2.7 8.4 0.1 3.5 1 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 KOO32591.1 - 0.12 12.4 8.5 0.56 10.3 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) SOGA PF11365.8 KOO32591.1 - 0.15 13.2 0.8 0.15 13.2 0.8 3.9 1 1 3 4 4 4 0 Protein SOGA DHR10 PF18595.1 KOO32591.1 - 0.16 12.0 27.3 0.038 14.0 2.9 3.0 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain SlyX PF04102.12 KOO32591.1 - 0.29 11.8 23.8 0.092 13.4 8.4 4.5 2 2 2 5 5 5 0 SlyX HAUS-augmin3 PF14932.6 KOO32591.1 - 0.43 10.1 20.5 0.023 14.3 10.8 2.2 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Med9 PF07544.13 KOO32591.1 - 0.44 10.7 9.5 0.75 9.9 0.4 3.3 1 1 2 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 EMP24_GP25L PF01105.24 KOO32591.1 - 0.56 10.1 2.3 1.8 8.5 0.1 2.5 1 1 2 3 3 3 0 emp24/gp25L/p24 family/GOLD KxDL PF10241.9 KOO32591.1 - 1.3 9.3 11.9 2.9 8.2 0.3 3.6 2 2 1 3 3 3 0 Uncharacterized conserved protein H-kinase_dim PF02895.14 KOO32591.1 - 1.8 9.0 13.2 2.4e+03 -1.0 13.2 4.0 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain Seryl_tRNA_N PF02403.22 KOO32591.1 - 2.4 8.4 16.1 0.5 10.6 2.2 2.7 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain RasGAP_C PF03836.15 KOO32591.1 - 2.8 8.1 8.0 10 6.3 3.2 3.0 1 1 1 3 3 3 0 RasGAP C-terminus PRKG1_interact PF15898.5 KOO32591.1 - 2.9 8.8 17.3 1.5 9.8 5.3 2.9 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Syntaxin-6_N PF09177.11 KOO32591.1 - 3.7 8.2 9.8 6.4 7.4 0.6 3.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal HIP1_clath_bdg PF16515.5 KOO32591.1 - 4.6 7.9 23.5 3.2 8.4 2.5 3.5 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TPR_MLP1_2 PF07926.12 KOO32591.1 - 6.7 6.8 26.8 1.9 8.6 11.0 3.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 KOO32591.1 - 8.8 5.3 15.6 0.27 10.3 6.5 1.9 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ank_4 PF13637.6 KOO32592.1 - 6e-16 58.6 1.3 3.8e-08 33.7 0.3 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO32592.1 - 6.7e-16 58.1 0.2 1.1e-10 41.6 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO32592.1 - 1.3e-14 54.5 0.0 1.6e-12 47.8 0.0 2.7 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO32592.1 - 1.8e-08 33.9 0.1 0.00086 19.6 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOO32592.1 - 1.6e-07 31.5 0.1 0.03 14.8 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Tcp11 PF05794.13 KOO32593.1 - 2.7e-13 49.8 1.8 1.5e-08 34.2 0.0 3.2 3 0 0 3 3 3 2 T-complex protein 11 UBA PF00627.31 KOO32593.1 - 2.1e-06 27.5 6.8 5.9e-06 26.1 2.9 2.7 2 0 0 2 2 2 1 UBA/TS-N domain XPC-binding PF09280.11 KOO32593.1 - 1.2e-05 24.9 2.9 0.089 12.5 0.0 3.5 3 0 0 3 3 3 2 XPC-binding domain Hexapep PF00132.24 KOO32594.1 - 3.9e-08 32.7 5.6 0.0083 15.8 1.6 3.6 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 KOO32594.1 - 0.0013 17.7 0.1 0.0018 17.3 0.1 1.2 1 0 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 KOO32594.1 - 0.0084 15.8 4.9 1.7 8.5 0.3 4.1 3 1 2 5 5 5 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 KOO32594.1 - 0.29 9.2 0.2 0.35 8.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Filamin PF00630.19 KOO32595.1 - 1.4e-17 64.4 0.0 6e-06 27.0 0.0 3.7 3 0 0 3 3 3 3 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO32595.1 - 0.00041 20.6 0.4 0.0086 16.4 0.3 2.9 3 0 0 3 3 3 1 Invasin, domain 3 SnoaL_4 PF13577.6 KOO32595.1 - 0.0028 17.8 0.1 0.012 15.7 0.1 2.0 2 0 0 2 2 2 1 SnoaL-like domain DUF1509 PF07420.11 KOO32595.1 - 7.2 5.5 9.1 13 4.6 9.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) VCBS PF13517.6 KOO32596.1 - 3.7e-59 197.2 77.7 2.8e-13 50.2 5.6 7.0 1 1 6 7 7 7 7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO32596.1 - 1.8e-28 98.3 74.0 0.0003 20.8 3.8 7.8 7 0 0 7 7 7 7 FG-GAP repeat Ephrin_rec_like PF07699.13 KOO32596.1 - 8.5e-19 67.1 72.9 1.2e-07 31.4 1.3 9.5 3 1 4 9 9 9 6 Putative ephrin-receptor like TcdB_toxin_midN PF12256.8 KOO32596.1 - 0.0011 18.4 16.9 2.2 7.6 0.1 6.3 6 0 0 6 6 6 3 Insecticide toxin TcdB middle/N-terminal region Dockerin_1 PF00404.18 KOO32596.1 - 0.0072 16.5 21.3 18 5.6 0.1 7.2 7 0 0 7 7 7 2 Dockerin type I domain Pax2_C PF12403.8 KOO32597.1 - 3.2 7.9 19.4 7.7 6.6 1.8 4.2 4 0 0 4 4 4 0 Paired-box protein 2 C terminal SET PF00856.28 KOO32598.1 - 3.6e-10 40.5 0.0 1.2e-09 38.7 0.0 1.8 1 1 0 1 1 1 1 SET domain Beta-lactamase PF00144.24 KOO32599.1 - 2.4e-13 50.0 1.1 8.5e-13 48.2 1.1 1.8 1 1 0 1 1 1 1 Beta-lactamase MFS_1 PF07690.16 KOO32600.1 - 2.1e-29 102.5 105.9 2.3e-13 49.8 33.2 4.1 2 2 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO32600.1 - 4.5e-24 85.1 3.8 4.5e-24 85.1 3.8 4.3 4 1 0 4 4 4 2 Sugar (and other) transporter Pam17 PF08566.10 KOO32600.1 - 2.4 8.0 6.3 9.4 6.1 0.2 3.3 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 Pkinase PF00069.25 KOO32601.1 - 1.4e-37 129.5 0.0 2.5e-37 128.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO32601.1 - 7.6e-16 58.0 0.0 7.9e-15 54.7 0.0 2.1 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO32601.1 - 3.2e-15 56.1 0.0 5.7e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO32601.1 - 0.028 13.7 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kinase-PolyVal PF18762.1 KOO32601.1 - 0.1 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins APG17 PF04108.12 KOO32602.1 - 0.00045 19.4 4.8 0.00065 18.9 4.8 1.3 1 0 0 1 1 1 1 Autophagy protein Apg17 Hrs_helical PF12210.8 KOO32602.1 - 0.16 12.5 3.7 0.38 11.3 3.7 1.6 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF3584 PF12128.8 KOO32602.1 - 0.29 8.6 16.4 0.35 8.3 16.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GAS PF13851.6 KOO32602.1 - 0.35 10.2 6.2 0.53 9.6 6.2 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding V_ATPase_I PF01496.19 KOO32602.1 - 4.1 5.2 3.9 5.4 4.8 3.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 KOO32602.1 - 7.9 5.3 13.7 9.7 5.0 10.1 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein Ank_4 PF13637.6 KOO32603.1 - 0.00048 20.6 0.0 0.0014 19.1 0.0 1.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO32603.1 - 0.00068 20.0 0.0 0.0029 18.0 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 KOO32603.1 - 0.0077 16.8 0.0 0.013 16.1 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO32603.1 - 0.03 14.9 0.0 2.9 8.8 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 KOO32603.1 - 0.048 14.0 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Glycos_transf_3 PF00591.21 KOO32605.1 - 2.8e-87 292.5 4.7 3.6e-87 292.2 4.7 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 KOO32605.1 - 9.8e-15 54.2 0.5 2.2e-14 53.0 0.1 1.8 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain Sld5 PF05916.11 KOO32606.1 - 2.1e-06 28.1 0.0 3.8e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 GINS complex protein EF-hand_1 PF00036.32 KOO32607.1 - 3.6e-52 170.1 17.8 2.3e-05 23.6 0.0 12.7 11 2 2 13 13 13 11 EF hand EF-hand_6 PF13405.6 KOO32607.1 - 7.3e-45 147.1 28.2 5.5e-05 22.8 0.0 12.4 11 2 2 13 13 13 9 EF-hand domain EF-hand_7 PF13499.6 KOO32607.1 - 5.7e-44 148.4 20.2 4.8e-09 36.5 0.2 8.4 7 2 1 8 8 8 7 EF-hand domain pair EF-hand_5 PF13202.6 KOO32607.1 - 8e-35 116.8 20.3 2.1e-06 26.9 0.0 10.9 11 0 0 11 11 11 7 EF hand EF-hand_8 PF13833.6 KOO32607.1 - 3.4e-27 94.1 15.1 5.4e-05 22.9 0.1 9.2 9 0 0 9 9 9 7 EF-hand domain pair EF-hand_9 PF14658.6 KOO32607.1 - 2.1e-06 28.0 2.9 0.97 9.8 0.0 5.9 6 0 0 6 6 6 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO32607.1 - 3.9e-06 27.2 3.4 2.3 8.5 0.0 5.3 5 1 1 6 6 6 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO32607.1 - 2e-05 24.6 0.4 11 5.9 0.0 6.2 5 1 0 6 6 6 1 Caleosin related protein EF-hand_14 PF17959.1 KOO32607.1 - 0.028 14.7 2.0 13 6.2 0.0 4.9 5 1 1 6 6 6 0 EF-hand domain Dockerin_1 PF00404.18 KOO32607.1 - 0.055 13.7 11.9 2.4 8.4 0.0 5.9 6 2 1 7 7 7 0 Dockerin type I domain Armet PF10208.9 KOO32607.1 - 0.089 12.7 0.1 0.25 11.3 0.1 1.8 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding SOUL PF04832.12 KOO32608.1 - 4.4e-13 49.7 0.0 5.1e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 SOUL heme-binding protein MFS_1 PF07690.16 KOO32609.1 - 1.6e-40 139.1 27.4 1.6e-40 139.1 27.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 KOO32609.1 - 0.0091 14.9 9.4 0.079 11.8 8.0 2.5 1 1 2 3 3 3 2 MFS_1 like family PRIMA1 PF16101.5 KOO32609.1 - 1.4 8.9 8.3 20 5.3 5.8 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 ZZ PF00569.17 KOO32610.1 - 0.038 13.8 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 Zinc finger, ZZ type CCB2_CCB4 PF11152.8 KOO32612.1 - 0.038 13.3 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 Rhodanese PF00581.20 KOO32614.1 - 0.00068 20.1 0.0 0.0013 19.2 0.0 1.5 1 1 0 1 1 1 1 Rhodanese-like domain Glyco_transf_7C PF02709.14 KOO32614.1 - 0.091 12.4 0.3 0.14 11.8 0.3 1.2 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase Phage_integrase PF00589.22 KOO32616.1 - 2e-06 27.7 0.0 7.2e-06 25.9 0.0 1.8 2 0 0 2 2 2 1 Phage integrase family DUF383 PF04063.14 KOO32617.1 - 0.032 13.9 0.0 0.58 9.8 0.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF383) DAGAT PF03982.13 KOO32619.1 - 9.6e-24 83.8 0.0 1.2e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase RTTN_N PF14726.6 KOO32620.1 - 0.0033 18.2 0.0 0.0072 17.1 0.0 1.5 1 0 0 1 1 1 1 Rotatin, an armadillo repeat protein, centriole functioning EF-hand_6 PF13405.6 KOO32621.1 - 1.3e-18 65.2 4.3 0.00031 20.4 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO32621.1 - 2.9e-18 64.0 11.6 6.8e-05 22.1 0.5 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO32621.1 - 2.6e-14 53.4 3.3 7.5e-06 26.3 0.6 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO32621.1 - 5e-14 51.1 11.0 0.0012 18.2 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO32621.1 - 7.2e-11 41.8 7.5 2.3e-05 24.1 3.3 2.9 2 1 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO32621.1 - 0.0094 16.3 3.5 1.5 9.2 0.1 3.7 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO32621.1 - 0.023 14.5 0.5 13 5.8 0.3 3.2 3 0 0 3 3 3 0 EF hand EspA PF03433.13 KOO32621.1 - 0.25 11.2 18.1 0.37 10.6 0.3 4.1 1 1 2 3 3 3 0 EspA-like secreted protein RNB PF00773.19 KOO32621.1 - 0.5 9.6 3.5 0.35 10.1 1.8 1.5 2 0 0 2 2 2 0 RNB domain Glyco_transf_90 PF05686.12 KOO32622.1 - 2.4e-37 128.8 0.1 3.2e-37 128.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 KOO32622.1 - 0.00033 21.0 0.0 0.00058 20.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Arm PF00514.23 KOO32623.1 - 4.1e-71 233.1 62.3 1.9e-06 27.7 0.0 22.1 23 0 0 23 23 23 17 Armadillo/beta-catenin-like repeat CAP_GLY PF01302.25 KOO32623.1 - 3.3e-15 55.9 0.2 6.7e-15 54.9 0.2 1.5 1 0 0 1 1 1 1 CAP-Gly domain DUF5578 PF17741.1 KOO32623.1 - 1.2e-07 31.5 7.8 0.013 14.9 0.0 5.5 4 1 3 7 7 7 2 Family of unknown function (DUF5578) V-ATPase_H_N PF03224.14 KOO32623.1 - 9.8e-07 28.4 0.0 0.022 14.0 0.0 5.1 2 2 3 5 5 5 1 V-ATPase subunit H Cnd1 PF12717.7 KOO32623.1 - 0.0041 17.2 0.0 3 7.9 0.0 4.8 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 JHY PF15261.6 KOO32623.1 - 0.0045 17.7 2.8 0.01 16.5 2.8 1.6 1 0 0 1 1 1 1 Jhy protein HEAT_2 PF13646.6 KOO32623.1 - 0.0063 16.9 0.4 0.0063 16.9 0.4 11.1 5 3 8 13 13 13 5 HEAT repeats Adaptin_N PF01602.20 KOO32623.1 - 0.0074 14.9 1.8 10 4.5 0.0 3.8 3 1 0 4 4 4 2 Adaptin N terminal region Arm_2 PF04826.13 KOO32623.1 - 0.051 13.0 0.0 45 3.4 0.1 4.5 4 1 1 5 5 5 0 Armadillo-like CLASP_N PF12348.8 KOO32623.1 - 0.099 12.2 0.7 19 4.8 0.0 3.8 4 0 0 4 4 4 0 CLASP N terminal HEAT_EZ PF13513.6 KOO32623.1 - 8.6 7.0 56.4 0.36 11.4 0.8 12.8 10 4 5 15 15 15 0 HEAT-like repeat Pkinase PF00069.25 KOO32624.1 - 7.2e-49 166.5 0.0 1.3e-48 165.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32624.1 - 3.7e-38 131.3 0.0 5.1e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.24 KOO32624.1 - 1.7e-05 25.0 0.1 5.2e-05 23.5 0.1 1.7 1 0 0 1 1 1 1 PDZ domain Pkinase_fungal PF17667.1 KOO32624.1 - 2.7e-05 23.2 0.0 4.3e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO32624.1 - 0.0091 15.3 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PDZ_2 PF13180.6 KOO32624.1 - 0.011 16.0 0.0 0.028 14.7 0.0 1.6 1 0 0 1 1 1 0 PDZ domain PDZ_6 PF17820.1 KOO32624.1 - 0.021 14.7 0.1 0.053 13.4 0.1 1.7 1 0 0 1 1 1 0 PDZ domain Peptidase_S28 PF05577.12 KOO32625.1 - 3.8e-10 39.1 0.0 5.2e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 PPR_3 PF13812.6 KOO32626.1 - 8.3e-21 73.8 0.0 3.8e-09 36.5 0.0 3.9 2 1 3 5 5 5 5 Pentatricopeptide repeat domain PPR_2 PF13041.6 KOO32626.1 - 1.2e-18 67.0 0.0 3.2e-10 40.0 0.0 4.1 4 1 1 5 5 5 3 PPR repeat family PPR PF01535.20 KOO32626.1 - 1.1e-15 56.7 0.0 0.0042 17.2 0.0 6.2 6 0 0 6 6 6 4 PPR repeat PPR_1 PF12854.7 KOO32626.1 - 2.4e-13 49.5 0.5 0.00022 20.9 0.0 4.6 4 0 0 4 4 4 3 PPR repeat PPR_long PF17177.4 KOO32626.1 - 7.4e-06 25.5 0.0 1.6e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP Dimerisation2 PF16864.5 KOO32626.1 - 0.097 12.7 0.5 11 6.1 0.1 2.2 2 0 0 2 2 2 0 Dimerisation domain ATP13 PF12921.7 KOO32626.1 - 0.21 11.4 0.0 6.3 6.7 0.0 2.5 2 1 1 3 3 3 0 Mitochondrial ATPase expression Ion_trans_2 PF07885.16 KOO32628.1 - 2.1e-28 98.1 17.1 2.8e-14 52.8 1.2 2.6 2 1 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KOO32628.1 - 4.3e-08 32.7 6.7 7.2e-05 22.1 3.8 2.1 2 0 0 2 2 2 2 Ion transport protein EF-hand_7 PF13499.6 KOO32628.1 - 5.9e-06 26.6 0.3 0.02 15.3 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO32628.1 - 4.1e-05 22.8 1.4 0.093 12.3 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO32628.1 - 5.2e-05 22.8 1.7 0.024 14.6 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO32628.1 - 0.00016 21.0 4.1 0.0082 15.6 0.8 2.5 2 0 0 2 2 2 2 EF hand RCC1_2 PF13540.6 KOO32629.1 - 8.3e-45 149.8 35.4 4.3e-10 39.1 0.5 9.4 9 0 0 9 9 9 9 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 KOO32629.1 - 1.3e-34 118.5 15.8 0.0017 18.9 0.0 10.4 9 1 0 9 9 9 8 Regulator of chromosome condensation (RCC1) repeat Pneumo_ncap PF03246.13 KOO32630.1 - 0.036 12.8 0.9 0.056 12.2 0.9 1.4 1 0 0 1 1 1 0 Pneumovirus nucleocapsid protein 3-PAP PF12578.8 KOO32630.1 - 0.12 12.1 4.9 3.2 7.5 0.0 2.8 2 1 0 2 2 2 0 Myotubularin-associated protein APG6_N PF17675.1 KOO32630.1 - 5.1 7.6 32.3 0.31 11.6 8.5 2.7 2 1 1 3 3 3 0 Apg6 coiled-coil region YebO PF13974.6 KOO32630.1 - 7.2 6.8 13.1 2.5 8.2 9.4 2.4 2 1 0 2 2 2 0 YebO-like protein SHQ1 PF04925.15 KOO32631.1 - 2.4e-51 173.8 0.0 3.7e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 SHQ1 protein ubiquitin PF00240.23 KOO32632.1 - 8.5e-05 22.2 0.0 0.23 11.3 0.0 3.3 3 0 0 3 3 3 2 Ubiquitin family TPR_7 PF13176.6 KOO32632.1 - 0.0015 18.4 0.0 0.0064 16.4 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO32632.1 - 0.005 16.8 0.5 0.046 13.9 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Rad60-SLD PF11976.8 KOO32632.1 - 0.072 12.9 0.0 1.3 8.9 0.0 2.6 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like TUG-UBL1 PF11470.8 KOO32632.1 - 0.098 12.9 0.3 20 5.5 0.0 2.5 2 0 0 2 2 2 0 TUG ubiquitin-like domain TPR_14 PF13428.6 KOO32632.1 - 0.12 13.3 0.0 0.49 11.4 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Arm PF00514.23 KOO32633.1 - 1.7e-47 158.1 33.2 7.1e-07 29.1 1.0 11.3 11 1 0 11 11 11 9 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO32633.1 - 4.8e-11 42.6 0.1 0.0073 16.3 0.0 4.9 4 0 0 4 4 4 3 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO32633.1 - 1e-07 31.7 0.0 0.023 14.2 0.0 3.5 1 1 1 2 2 2 2 Armadillo-like HEAT_EZ PF13513.6 KOO32633.1 - 1.2e-07 32.1 46.7 0.00063 20.2 0.3 8.5 7 1 1 8 8 8 5 HEAT-like repeat V-ATPase_H_N PF03224.14 KOO32633.1 - 3.4e-06 26.6 0.0 0.24 10.7 0.0 3.8 1 1 2 3 3 3 3 V-ATPase subunit H HEAT PF02985.22 KOO32633.1 - 1 9.8 12.2 22 5.7 0.0 6.8 8 0 0 8 8 8 0 HEAT repeat FlxA PF14282.6 KOO32633.1 - 1.3 9.0 6.9 7.1 6.7 1.5 2.8 2 0 0 2 2 2 0 FlxA-like protein Ion_trans PF00520.31 KOO32634.1 - 2.7e-189 626.1 0.0 3.9e-55 186.7 0.0 4.1 3 1 1 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO32634.1 - 1.3e-06 28.1 0.0 3.8e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO32634.1 - 2.6e-05 23.1 8.4 2.6e-05 23.1 8.4 8.1 8 2 2 10 10 10 3 Polycystin cation channel FragX_IP PF05994.11 KOO32635.1 - 1.8e-163 545.7 0.0 1.5e-162 542.7 0.0 1.9 1 1 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.12 KOO32635.1 - 0.0021 17.4 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Pkinase PF00069.25 KOO32636.1 - 3.3e-31 108.6 0.0 4.6e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32636.1 - 3.7e-31 108.4 0.0 5.1e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO32636.1 - 0.00083 19.3 0.6 0.015 15.2 0.3 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO32636.1 - 0.0063 15.9 0.0 0.0095 15.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SKG6 PF08693.10 KOO32636.1 - 0.076 12.4 0.2 0.19 11.1 0.2 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pkinase_fungal PF17667.1 KOO32636.1 - 0.11 11.3 0.0 0.24 10.1 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase cobW PF02492.19 KOO32637.1 - 8.5e-42 142.7 0.0 1.3e-41 142.1 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KOO32637.1 - 4.3e-23 81.1 0.1 3e-22 78.3 0.1 2.3 2 1 0 2 2 2 1 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.14 KOO32637.1 - 0.0029 17.5 0.5 0.0065 16.4 0.0 1.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 KOO32637.1 - 0.0081 16.7 0.1 0.017 15.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 KOO32637.1 - 0.028 14.4 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KOO32637.1 - 0.056 13.6 0.1 0.13 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain PE_PPE_C PF12484.8 KOO32637.1 - 0.51 11.3 8.3 0.087 13.7 3.0 2.4 2 0 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal bZIP_1 PF00170.21 KOO32638.1 - 6e-08 32.7 3.8 9.9e-08 32.0 3.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KOO32638.1 - 7.9e-05 22.7 7.2 0.00015 21.7 7.2 1.4 1 0 0 1 1 1 1 Basic region leucine zipper adh_short_C2 PF13561.6 KOO32639.1 - 7.4e-56 189.3 5.7 8.7e-56 189.1 5.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO32639.1 - 2.3e-54 183.8 5.4 2.8e-54 183.5 5.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOO32639.1 - 1.2e-13 51.4 1.3 1.6e-13 51.0 0.5 1.5 1 1 1 2 2 2 1 KR domain 3HCDH_N PF02737.18 KOO32639.1 - 0.00016 21.7 0.3 0.0003 20.7 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 KOO32639.1 - 0.00017 21.1 0.5 0.00031 20.3 0.5 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PALP PF00291.25 KOO32639.1 - 0.0015 18.0 1.6 0.0021 17.5 0.4 1.7 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme ELFV_dehydrog PF00208.21 KOO32639.1 - 0.0047 16.7 1.0 0.031 14.0 0.2 2.0 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Methyltransf_25 PF13649.6 KOO32639.1 - 0.0061 17.2 0.0 0.019 15.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain GDP_Man_Dehyd PF16363.5 KOO32639.1 - 0.01 15.3 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase ApbA PF02558.16 KOO32639.1 - 0.015 14.9 0.3 0.03 14.0 0.3 1.5 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 KOO32639.1 - 0.027 14.7 0.2 0.065 13.5 0.2 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 KOO32639.1 - 0.041 13.8 4.5 0.06 13.2 4.5 1.4 1 1 0 1 1 1 0 NAD(P)H-binding Methyltransf_12 PF08242.12 KOO32639.1 - 0.055 14.2 0.0 0.12 13.1 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 KOO32639.1 - 0.067 12.8 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UPF0146 PF03686.13 KOO32639.1 - 0.068 13.0 0.1 0.18 11.7 0.0 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0146) 3Beta_HSD PF01073.19 KOO32639.1 - 0.074 12.0 0.1 0.11 11.4 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Ldh_1_N PF00056.23 KOO32639.1 - 0.1 12.7 1.8 0.22 11.6 0.3 2.1 2 1 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain ThiF PF00899.21 KOO32639.1 - 3.4 7.0 6.1 1.8 7.9 2.1 2.2 1 1 1 2 2 2 0 ThiF family zf-CW PF07496.15 KOO32640.1 - 3.1e-13 49.5 4.3 1e-12 47.8 3.4 2.4 2 0 0 2 2 2 1 CW-type Zinc Finger zf-CXXC PF02008.20 KOO32640.1 - 1.1e-10 41.4 20.9 1.1e-10 41.4 20.9 3.0 4 0 0 4 4 4 1 CXXC zinc finger domain V_ATPase_I PF01496.19 KOO32640.1 - 0.14 10.1 5.7 0.18 9.7 5.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MAD PF05557.13 KOO32640.1 - 2.3 6.5 24.9 3.4 5.9 24.9 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein FliT PF05400.13 KOO32641.1 - 0.074 13.9 0.0 0.089 13.6 0.0 1.2 1 0 0 1 1 1 0 Flagellar protein FliT TcdA_TcdB_pore PF12920.7 KOO32641.1 - 0.17 10.1 0.3 0.16 10.1 0.3 1.0 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain Hint PF01079.20 KOO32642.1 - 1.6e-13 50.7 0.5 1.2e-11 44.5 0.3 2.2 1 1 0 1 1 1 1 Hint module TruB_C PF09142.11 KOO32644.1 - 0.12 12.2 0.8 0.44 10.4 0.8 1.9 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal JmjC PF02373.22 KOO32646.1 - 2.6e-05 24.6 0.7 0.00016 22.1 0.0 2.5 2 1 1 3 3 3 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 KOO32646.1 - 0.005 16.6 0.4 0.011 15.4 0.2 1.6 1 1 1 2 2 2 1 Cupin-like domain Cupin_4 PF08007.12 KOO32646.1 - 0.019 14.4 0.1 0.039 13.4 0.1 1.5 1 0 0 1 1 1 0 Cupin superfamily protein Collagen PF01391.18 KOO32649.1 - 0.00051 19.8 9.6 0.00051 19.8 9.6 2.1 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) PRP38 PF03371.15 KOO32651.1 - 2.2e-40 138.4 0.0 3e-40 137.9 0.0 1.1 1 0 0 1 1 1 1 PRP38 family Sulfatase PF00884.23 KOO32652.1 - 2e-17 63.6 0.0 6.1e-16 58.7 0.0 2.6 1 1 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 KOO32652.1 - 8.9e-05 22.2 0.0 0.00016 21.4 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PAP_fibrillin PF04755.12 KOO32653.1 - 0.00012 22.1 0.0 0.00046 20.2 0.0 1.8 2 0 0 2 2 2 1 PAP_fibrillin Exo_endo_phos PF03372.23 KOO32654.1 - 9.5e-06 25.3 0.4 0.018 14.6 0.0 2.2 1 1 1 2 2 2 2 Endonuclease/Exonuclease/phosphatase family Exostosin PF03016.15 KOO32656.1 - 2.2e-14 53.4 0.0 3.3e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Exostosin family DNA_primase_lrg PF04104.14 KOO32657.1 - 5e-78 262.2 0.0 7.3e-78 261.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit HTH_54 PF18607.1 KOO32657.1 - 0.04 14.0 0.1 4.4 7.4 0.0 2.7 2 0 0 2 2 2 0 ParA helix turn helix domain p25-alpha PF05517.12 KOO32658.1 - 0.015 15.5 32.8 0.25 11.5 0.4 12.5 15 1 0 15 15 15 0 p25-alpha UPF0227 PF05728.12 KOO32658.1 - 0.13 12.1 0.1 0.31 11.0 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) CRISPR_Cas6 PF10040.9 KOO32658.1 - 0.14 12.8 3.0 40 4.9 0.1 5.9 6 1 0 6 6 6 0 CRISPR-associated endoribonuclease Cas6 DUF4179 PF13786.6 KOO32658.1 - 0.16 12.5 0.4 1.7 9.2 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Abhydrolase_6 PF12697.7 KOO32658.1 - 0.17 12.5 0.6 0.55 10.8 0.1 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF2670 PF10875.8 KOO32658.1 - 0.19 11.8 2.6 1.6e+02 2.4 0.0 5.4 6 0 0 6 6 6 0 Protein of unknown function (DUF2670) DUF1877 PF08974.10 KOO32658.1 - 7.5 6.6 6.9 41 4.2 0.0 5.1 7 0 0 7 7 7 0 Domain of unknown function (DUF1877) PPR_2 PF13041.6 KOO32659.1 - 7.7e-17 61.2 0.0 1.2e-08 35.0 0.0 2.6 1 1 2 3 3 3 3 PPR repeat family PPR PF01535.20 KOO32659.1 - 6.5e-12 44.9 0.0 0.014 15.6 0.0 3.2 3 0 0 3 3 3 3 PPR repeat PPR_1 PF12854.7 KOO32659.1 - 5.3e-10 38.8 0.1 0.0004 20.0 0.0 3.2 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 KOO32659.1 - 3.7e-08 33.3 0.0 4e-06 26.8 0.0 1.8 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO32659.1 - 0.00011 21.7 0.0 0.00013 21.4 0.0 1.1 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 KOO32659.1 - 0.032 15.0 2.9 7.3 7.7 0.0 3.8 1 1 3 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO32659.1 - 0.11 13.2 5.9 17 6.4 0.4 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Metallophos PF00149.28 KOO32660.1 - 9e-08 32.9 0.8 1.5e-07 32.2 0.2 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DnaJ PF00226.31 KOO32661.1 - 2e-22 79.1 1.5 3.1e-22 78.5 1.5 1.3 1 0 0 1 1 1 1 DnaJ domain Ge1_WD40 PF16529.5 KOO32662.1 - 1.7e-06 27.2 0.0 3.3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein GerPC PF10737.9 KOO32662.1 - 0.012 15.6 0.0 0.15 12.1 0.0 2.2 2 0 0 2 2 2 0 Spore germination protein GerPC YpjP PF14005.6 KOO32662.1 - 0.071 13.2 0.0 0.41 10.7 0.0 2.3 2 1 1 3 3 3 0 YpjP-like protein AbiTii PF18864.1 KOO32662.1 - 0.2 11.8 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 AbiTii MORN PF02493.20 KOO32663.1 - 1.4e-31 106.5 40.6 7.3e-08 31.9 0.3 9.3 9 1 1 10 10 10 7 MORN repeat ECR1_N PF14382.6 KOO32663.1 - 0.013 15.3 4.5 2.2 8.2 0.0 4.4 4 0 0 4 4 4 0 Exosome complex exonuclease RRP4 N-terminal region DUF3048_C PF17479.2 KOO32663.1 - 0.47 10.8 20.7 0.45 10.9 2.2 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF3048) C-terminal domain ubiquitin PF00240.23 KOO32666.1 - 8.1e-05 22.3 0.0 0.032 14.0 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin family 2OG-FeII_Oxy_5 PF13759.6 KOO32668.1 - 7.3e-10 39.2 0.2 3.2e-08 33.9 0.0 2.8 3 0 0 3 3 3 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 KOO32668.1 - 0.0058 17.5 0.0 0.012 16.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EMP70 PF02990.16 KOO32670.1 - 9.1e-180 598.7 31.0 7e-99 331.8 30.7 2.2 1 1 1 2 2 2 2 Endomembrane protein 70 Ion_trans PF00520.31 KOO32672.1 - 7.8e-199 657.3 56.0 1.3e-57 194.9 6.4 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO32672.1 - 2.4e-06 27.2 0.0 6.1e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO32672.1 - 4.7e-06 25.5 9.1 1.1e-05 24.3 3.0 8.9 7 2 2 9 9 9 6 Polycystin cation channel Galactosyl_T PF01762.21 KOO32673.1 - 0.00039 20.3 0.0 0.0012 18.7 0.0 1.7 1 1 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 KOO32673.1 - 0.25 10.7 0.0 0.5 9.8 0.0 1.5 1 1 0 1 1 1 0 Fringe-like Cys_Knot_tox PF17486.2 KOO32673.1 - 0.34 11.2 4.2 1.1 9.5 4.2 1.9 1 0 0 1 1 1 0 Cystine knot toxins DUF1798 PF08807.10 KOO32674.1 - 0.016 15.4 0.1 0.016 15.4 0.1 4.7 4 2 0 5 5 5 0 Bacterial domain of unknown function (DUF1798) Spc7 PF08317.11 KOO32675.1 - 0.013 14.4 4.5 0.029 13.2 4.5 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein WD40 PF00400.32 KOO32676.1 - 1.3e-22 79.6 0.6 0.0018 19.1 0.0 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO32676.1 - 4.1e-16 59.0 0.0 0.0026 18.0 0.0 5.0 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PHM7_cyt PF14703.6 KOO32677.1 - 2.1e-11 44.3 0.0 3.5e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_7TM PF02714.15 KOO32677.1 - 0.0036 16.7 3.4 0.0036 16.7 3.4 1.9 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RRM_1 PF00076.22 KOO32677.1 - 0.042 13.7 0.0 0.54 10.1 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Abhydrolase_9_N PF15420.6 KOO32677.1 - 0.16 12.0 13.5 0.14 12.1 4.4 3.3 3 0 0 3 3 3 0 Alpha/beta-hydrolase family N-terminus CS PF04969.16 KOO32678.1 - 1.7e-14 54.6 0.2 3.5e-14 53.6 0.2 1.6 1 0 0 1 1 1 1 CS domain Nudc_N PF14050.6 KOO32678.1 - 4.8e-13 48.9 0.4 1.4e-12 47.4 0.4 1.8 1 1 0 1 1 1 1 N-terminal conserved domain of Nudc. Nop25 PF09805.9 KOO32678.1 - 0.39 11.2 19.4 0.023 15.2 13.1 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) FAM60A PF15396.6 KOO32678.1 - 2.1 8.3 15.9 0.75 9.8 9.1 2.1 2 0 0 2 2 2 0 Protein Family FAM60A SAGA-Tad1 PF12767.7 KOO32678.1 - 2.7 7.6 11.7 0.24 11.1 6.9 1.6 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit WD40 PF00400.32 KOO32679.1 - 1.5e-31 107.9 7.5 1.8e-09 38.1 0.1 3.6 4 0 0 4 4 3 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO32679.1 - 6.1e-10 38.6 0.2 0.042 12.8 0.0 3.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO32679.1 - 3e-08 33.8 1.0 0.037 14.3 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO32679.1 - 7.7e-08 32.1 0.0 0.69 9.9 0.0 3.3 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat eIF2A PF08662.11 KOO32679.1 - 0.00026 20.9 0.3 0.00045 20.1 0.3 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 KOO32679.1 - 0.0005 18.5 0.0 0.043 12.1 0.0 2.1 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz DCX PF03607.17 KOO32679.1 - 0.0061 16.6 0.0 11 6.2 0.0 3.2 3 0 0 3 3 3 1 Doublecortin Plk4_PB1 PF18190.1 KOO32679.1 - 0.0062 16.7 0.0 4.1 7.6 0.0 3.1 1 1 2 3 3 3 1 Polo-like Kinase 4 Polo Box 1 FlaE PF07559.14 KOO32679.1 - 0.079 13.5 0.1 0.17 12.5 0.1 1.6 1 1 0 1 1 1 0 Flagellar basal body protein FlaE dsrm PF00035.26 KOO32679.1 - 0.094 13.4 0.0 6.4 7.6 0.0 2.8 3 0 0 3 3 3 0 Double-stranded RNA binding motif WD40_like PF17005.5 KOO32679.1 - 0.095 12.0 0.0 1 8.6 0.0 2.1 1 1 1 2 2 2 0 WD40-like domain Proteasome_A_N PF10584.9 KOO32679.1 - 0.61 9.8 3.4 76 3.1 0.1 3.3 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature PAPS_reduct PF01507.19 KOO32680.1 - 1.8e-24 86.7 0.0 3.6e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Thioredoxin PF00085.20 KOO32680.1 - 1.8e-07 31.1 0.0 3.9e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOO32680.1 - 0.023 15.1 0.1 0.16 12.4 0.1 2.3 1 1 0 1 1 1 0 Thioredoxin-like domain PAP_fibrillin PF04755.12 KOO32681.1 - 0.00028 20.9 0.1 0.00078 19.4 0.1 1.6 1 1 1 2 2 2 1 PAP_fibrillin GRA6 PF05084.13 KOO32681.1 - 0.061 13.3 0.5 0.14 12.1 0.4 1.6 2 0 0 2 2 2 0 Granule antigen protein (GRA6) DUF3774 PF12609.8 KOO32682.1 - 0.014 16.4 0.1 0.17 12.9 0.2 2.4 2 0 0 2 2 2 0 Wound-induced protein PsbQ PF05757.11 KOO32682.1 - 0.51 10.0 4.7 0.17 11.6 0.2 2.3 2 0 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) CLASP_N PF12348.8 KOO32683.1 - 6.4e-48 163.3 1.3 2.9e-28 99.0 0.0 4.5 4 0 0 4 4 4 3 CLASP N terminal HEAT PF02985.22 KOO32683.1 - 2e-13 49.3 46.4 0.0044 17.1 0.0 13.6 14 0 0 14 14 14 3 HEAT repeat Cnd1 PF12717.7 KOO32683.1 - 1.2e-09 38.4 10.3 5.1 7.1 0.0 7.9 6 2 2 9 9 9 4 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 KOO32683.1 - 3.5e-09 37.0 4.9 0.00023 21.3 0.7 5.0 4 1 1 5 5 5 2 Parkin co-regulated protein HEAT_2 PF13646.6 KOO32683.1 - 4.6e-07 30.1 48.9 0.22 12.0 0.7 10.0 6 3 6 12 12 12 8 HEAT repeats HEAT_EZ PF13513.6 KOO32683.1 - 3.9e-06 27.2 32.7 0.0055 17.2 0.2 9.4 9 1 1 10 10 10 2 HEAT-like repeat Tti2 PF10521.9 KOO32683.1 - 0.0019 17.8 0.6 3.8 7.0 0.1 3.6 4 1 0 4 4 4 2 Tti2 family Vac14_Fab1_bd PF12755.7 KOO32683.1 - 0.0071 16.9 0.1 27 5.5 0.1 5.5 7 1 1 8 8 7 0 Vacuolar 14 Fab1-binding region DUF3363 PF11843.8 KOO32683.1 - 0.053 12.5 0.4 0.11 11.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3363) DUF1981 PF09324.10 KOO32683.1 - 0.057 13.3 0.0 2.6 8.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) MMS19_C PF12460.8 KOO32683.1 - 0.062 12.4 15.3 0.22 10.6 0.1 4.8 5 1 0 5 5 5 0 RNAPII transcription regulator C-terminal Adaptin_N PF01602.20 KOO32683.1 - 0.16 10.5 13.4 9.7 4.6 2.4 5.7 6 1 0 6 6 6 0 Adaptin N terminal region Arm PF00514.23 KOO32683.1 - 1.4 9.1 10.5 29 4.9 0.5 6.1 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat DSPc PF00782.20 KOO32684.1 - 1.6e-22 79.7 0.0 2.1e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOO32684.1 - 0.00019 21.1 0.0 0.00027 20.6 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KOO32684.1 - 0.021 15.1 0.0 0.03 14.6 0.0 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain Myotub-related PF06602.14 KOO32684.1 - 0.23 10.3 0.0 0.31 9.9 0.0 1.1 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain LRR_RI_capping PF18779.1 KOO32685.1 - 0.072 12.8 0.1 0.24 11.1 0.1 1.9 2 0 0 2 2 2 0 Capping Ribonuclease inhibitor Leucine Rich Repeat Fasciclin PF02469.22 KOO32686.1 - 1.5e-34 119.0 0.0 2.2e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Fasciclin domain Glyco_transf_21 PF13506.6 KOO32687.1 - 2.3e-08 33.7 0.0 6.5e-08 32.2 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 KOO32687.1 - 1.3e-06 28.5 0.0 5e-06 26.6 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 KOO32687.1 - 0.00022 21.1 0.0 0.0004 20.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 KOO32687.1 - 0.029 14.3 1.4 0.059 13.3 1.4 1.5 1 0 0 1 1 1 0 Glycosyl transferase family group 2 Chitin_synth_2 PF03142.15 KOO32687.1 - 0.16 10.5 0.0 0.24 10.0 0.0 1.1 1 0 0 1 1 1 0 Chitin synthase LRR_8 PF13855.6 KOO32688.1 - 6.8e-07 29.0 0.7 1.6e-06 27.8 0.7 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KOO32688.1 - 4e-06 27.1 5.4 0.00066 20.0 0.5 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) RRM_1 PF00076.22 KOO32688.1 - 8.6e-05 22.3 1.5 1.3 8.9 0.1 3.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fzo_mitofusin PF04799.13 KOO32688.1 - 0.022 14.3 8.7 0.055 13.0 8.7 1.7 1 0 0 1 1 1 0 fzo-like conserved region Cas_DxTHG PF09455.10 KOO32688.1 - 0.024 14.2 1.3 0.052 13.1 1.3 1.5 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family Dna2 PF08696.11 KOO32688.1 - 0.13 12.1 4.5 0.24 11.2 4.5 1.4 1 0 0 1 1 1 0 DNA replication factor Dna2 UPF0014 PF03649.13 KOO32688.1 - 0.17 11.2 1.7 0.3 10.4 1.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0014) V_ATPase_I_N PF18670.1 KOO32688.1 - 0.27 11.7 7.7 0.092 13.1 0.2 3.4 2 1 1 3 3 3 0 V-type ATPase subunit I, N-terminal domain FapA PF03961.13 KOO32688.1 - 0.33 9.5 8.6 0.6 8.6 8.6 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prominin PF05478.11 KOO32688.1 - 0.43 8.5 6.7 0.65 7.9 6.7 1.2 1 0 0 1 1 1 0 Prominin DUF1664 PF07889.12 KOO32688.1 - 0.43 10.6 5.7 1.4 8.9 5.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TRP PF06011.12 KOO32688.1 - 0.75 8.5 4.7 0.76 8.4 0.3 2.6 2 1 1 3 3 3 0 Transient receptor potential (TRP) ion channel DUF3810 PF12725.7 KOO32688.1 - 1.3 8.4 3.8 0.92 8.8 0.3 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3810) EST1_DNA_bind PF10373.9 KOO32688.1 - 1.5 8.2 4.0 2.9 7.3 4.0 1.4 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain RHD3 PF05879.12 KOO32688.1 - 1.7 6.7 9.7 2.9 5.9 9.7 1.3 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) FAST_2 PF08368.12 KOO32688.1 - 1.8 9.4 11.4 0.9 10.4 6.9 2.6 1 1 1 2 2 2 0 FAST kinase-like protein, subdomain 2 DUF1515 PF07439.11 KOO32688.1 - 2.5 8.2 9.2 12 5.9 0.1 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1515) V_ATPase_I PF01496.19 KOO32688.1 - 2.6 5.9 4.2 4.2 5.2 4.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_11 PF13086.6 KOO32688.1 - 3.7 7.3 7.5 0.24 11.2 0.9 2.1 2 0 0 2 2 2 0 AAA domain DUF445 PF04286.12 KOO32688.1 - 5.3 6.7 11.4 0.25 11.1 5.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF445) Sigma70_ner PF04546.13 KOO32688.1 - 6.4 6.6 13.1 0.17 11.8 6.1 1.9 2 0 0 2 2 1 0 Sigma-70, non-essential region DUF2748 PF10871.8 KOO32688.1 - 7.5 5.1 8.2 12 4.4 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) Exonuc_VII_L PF02601.15 KOO32688.1 - 8 5.9 15.4 0.023 14.3 3.0 2.4 3 0 0 3 3 2 0 Exonuclease VII, large subunit TMPIT PF07851.13 KOO32688.1 - 8.2 5.6 9.2 19 4.3 9.2 1.6 1 0 0 1 1 1 0 TMPIT-like protein Pkinase PF00069.25 KOO32689.1 - 7.8e-27 94.3 0.0 1e-26 93.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32689.1 - 0.021 14.1 0.0 0.047 13.0 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase Kinase-like PF14531.6 KOO32689.1 - 0.18 11.1 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like HSBP1 PF06825.12 KOO32691.1 - 0.14 12.0 0.9 0.27 11.1 0.2 1.8 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Arm PF00514.23 KOO32692.1 - 2.2e-43 145.0 4.7 5.3e-07 29.5 0.6 7.2 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO32692.1 - 0.00037 20.8 24.6 0.5 10.8 1.9 4.1 1 1 3 4 4 4 4 HEAT repeats HEAT PF02985.22 KOO32692.1 - 0.00071 19.6 4.5 2.2 8.8 0.0 5.2 5 0 0 5 5 5 1 HEAT repeat Op_neuropeptide PF08035.11 KOO32692.1 - 0.00095 19.0 0.1 11 5.9 0.0 3.9 3 0 0 3 3 3 2 Opioids neuropeptide Atx10homo_assoc PF09759.9 KOO32692.1 - 0.0013 18.7 0.0 4.3 7.4 0.0 3.8 2 1 2 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Succ_CoA_lig PF13607.6 KOO32692.1 - 0.042 13.6 17.3 2.6 7.9 2.7 4.6 1 1 5 6 6 6 0 Succinyl-CoA ligase like flavodoxin domain Arm_2 PF04826.13 KOO32692.1 - 0.046 13.2 0.0 14 5.1 0.0 2.6 1 1 0 2 2 2 0 Armadillo-like Alkyl_sulf_dimr PF14863.6 KOO32692.1 - 0.083 13.4 3.3 0.11 13.0 0.5 2.3 1 1 2 3 3 3 0 Alkyl sulfatase dimerisation DUF2537 PF10801.8 KOO32692.1 - 0.14 12.4 2.7 3.5 7.9 0.2 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2537) mono-CXXC PF15626.6 KOO32692.1 - 0.22 11.9 2.8 75 3.8 0.1 3.6 3 0 0 3 3 3 0 single CXXC unit HEAT_EZ PF13513.6 KOO32692.1 - 0.95 10.0 0.1 0.95 10.0 0.1 5.4 3 1 2 5 5 5 0 HEAT-like repeat PMT PF02366.18 KOO32693.1 - 9.7e-45 153.1 8.7 1.4e-44 152.5 8.7 1.2 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOO32693.1 - 3.1e-24 85.7 0.9 8.1e-16 58.2 0.2 2.4 2 0 0 2 2 2 2 C-terminal four TMM region of protein-O-mannosyltransferase Phos_pyr_kin PF08543.12 KOO32694.1 - 1e-71 241.2 4.6 1.4e-71 240.7 4.6 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 KOO32694.1 - 3.3e-21 76.1 0.0 5.3e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 TENA/THI-4/PQQC family SDH_sah PF01972.16 KOO32694.1 - 0.0023 17.0 1.1 0.0035 16.4 1.1 1.2 1 0 0 1 1 1 1 Serine dehydrogenase proteinase TPR_12 PF13424.6 KOO32695.1 - 7.7e-38 128.6 22.8 7.4e-18 64.6 2.5 3.2 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO32695.1 - 2.5e-37 125.7 17.0 7.5e-12 44.7 0.1 5.1 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOO32695.1 - 2.7e-10 39.6 7.7 0.0059 16.4 0.7 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO32695.1 - 1.2e-07 31.2 14.1 0.0081 16.2 0.4 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO32695.1 - 1.6e-07 30.8 15.6 0.02 14.9 0.1 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_4 PF07721.14 KOO32695.1 - 5.7e-06 26.5 21.9 0.0068 16.9 0.1 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO32695.1 - 6.9e-06 26.5 12.4 0.0062 17.0 1.2 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO32695.1 - 1.8e-05 25.3 22.5 0.013 16.2 0.6 4.5 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO32695.1 - 2.4e-05 24.2 6.7 0.036 14.3 0.2 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO32695.1 - 2.5e-05 23.8 7.6 9.1e-05 22.0 3.3 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_17 PF13431.6 KOO32695.1 - 0.00021 21.5 1.2 0.72 10.4 0.1 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO32695.1 - 0.00032 21.3 16.9 0.13 13.2 0.4 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_5 PF12688.7 KOO32695.1 - 0.0072 16.6 7.8 0.2 11.9 0.8 2.6 2 1 1 3 3 3 2 Tetratrico peptide repeat DUF4404 PF14357.6 KOO32695.1 - 0.022 15.4 0.2 22 5.8 0.0 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) 14-3-3 PF00244.20 KOO32695.1 - 0.027 14.0 1.1 0.034 13.7 0.3 1.6 2 0 0 2 2 2 0 14-3-3 protein ANAPC3 PF12895.7 KOO32695.1 - 0.078 13.2 7.3 0.59 10.4 0.7 3.1 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KOO32695.1 - 1.6 9.5 0.1 1.6 9.5 0.1 4.6 5 1 0 5 5 5 0 Tetratricopeptide repeat ANAPC5 PF12862.7 KOO32695.1 - 1.9 8.6 4.8 2.2 8.4 2.1 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 Ank_2 PF12796.7 KOO32696.1 - 2.1e-27 95.6 0.0 1.6e-12 47.8 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO32696.1 - 2.2e-26 91.1 5.9 5.2e-06 26.7 0.1 4.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KOO32696.1 - 6.5e-26 87.6 0.4 3e-05 24.0 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 KOO32696.1 - 3.7e-25 88.0 1.6 1.9e-09 37.9 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO32696.1 - 4.2e-22 77.9 3.5 2.3e-07 31.0 0.1 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Kinesin PF00225.23 KOO32697.1 - 5.1e-76 255.8 0.0 6.4e-76 255.4 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO32697.1 - 6.2e-17 61.9 0.0 9.3e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding ACBP PF00887.19 KOO32698.1 - 1.1e-15 57.6 0.0 1.8e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein BSD PF03909.17 KOO32698.1 - 9.4e-06 25.5 0.4 1.7e-05 24.7 0.4 1.4 1 0 0 1 1 1 1 BSD domain HU-CCDC81_euk_2 PF18289.1 KOO32699.1 - 0.00032 20.8 0.0 0.0066 16.6 0.0 2.7 3 0 0 3 3 3 1 CCDC81 eukaryotic HU domain 2 HU-CCDC81_euk_1 PF14908.6 KOO32699.1 - 0.00071 19.7 1.0 0.003 17.7 0.1 2.5 2 1 0 2 2 2 1 CCDC81 eukaryotic HU domain 1 SPOC PF07744.13 KOO32699.1 - 1.9 8.4 5.1 0.72 9.8 1.4 2.0 2 0 0 2 2 2 0 SPOC domain DnaJ PF00226.31 KOO32700.1 - 1e-05 25.6 0.5 2.5e-05 24.3 0.5 1.7 1 0 0 1 1 1 1 DnaJ domain OMP_b-brl PF13505.6 KOO32701.1 - 0.12 12.5 5.2 0.12 12.5 0.9 2.5 1 1 0 2 2 2 0 Outer membrane protein beta-barrel domain Ank_2 PF12796.7 KOO32702.1 - 5.8e-27 94.1 1.1 9.6e-16 58.2 0.0 3.0 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO32702.1 - 2.1e-21 76.0 0.3 3.6e-07 30.6 0.0 4.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KOO32702.1 - 1.9e-20 72.3 9.4 0.00019 21.7 0.0 6.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 KOO32702.1 - 1.3e-18 66.8 1.8 2.6e-06 27.6 0.0 5.3 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO32702.1 - 8.2e-18 62.7 0.9 0.00093 19.5 0.0 6.8 6 0 0 6 6 6 3 Ankyrin repeat PSII_Pbs27 PF13326.6 KOO32702.1 - 0.05 13.9 0.0 2.3 8.5 0.0 2.6 3 0 0 3 3 3 0 Photosystem II Pbs27 SoPB_HTH PF18090.1 KOO32702.1 - 0.066 13.4 0.5 2.4 8.3 0.2 2.7 2 0 0 2 2 2 0 Centromere-binding protein HTH domain Atg14 PF10186.9 KOO32704.1 - 0.07 12.2 12.0 0.052 12.6 3.2 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4224 PF13986.6 KOO32704.1 - 0.15 12.0 1.4 0.5 10.3 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4224) ZapB PF06005.12 KOO32704.1 - 0.22 12.0 13.5 6.9 7.2 0.3 3.8 3 1 1 4 4 4 0 Cell division protein ZapB CC2-LZ PF16516.5 KOO32704.1 - 0.27 11.6 0.1 0.27 11.6 0.1 2.7 3 1 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator UPF0449 PF15136.6 KOO32704.1 - 0.52 10.8 8.2 9.1 6.8 0.2 2.9 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 GAS PF13851.6 KOO32704.1 - 1.1 8.6 11.7 1.1 8.5 3.7 3.0 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Troponin PF00992.20 KOO32704.1 - 1.2 9.5 9.6 0.08 13.2 2.9 2.2 3 0 0 3 3 3 0 Troponin Atx10homo_assoc PF09759.9 KOO32705.1 - 1.7e-07 31.2 0.0 6.2e-06 26.2 0.0 3.0 1 1 1 2 2 2 2 Spinocerebellar ataxia type 10 protein domain Aldedh PF00171.22 KOO32707.1 - 2e-34 118.9 0.0 2.9e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family WW PF00397.26 KOO32708.1 - 4.6e-05 23.4 2.8 0.028 14.5 0.8 2.8 2 1 0 2 2 2 2 WW domain zf-HC2 PF13490.6 KOO32708.1 - 0.068 13.4 0.1 0.23 11.7 0.1 2.0 1 0 0 1 1 1 0 Putative zinc-finger TraH PF06122.11 KOO32708.1 - 0.2 10.9 0.0 0.39 9.9 0.0 1.4 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein Tubulin PF00091.25 KOO32709.1 - 6.1e-18 65.7 0.0 6.6e-18 65.6 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 KOO32709.1 - 0.00018 21.8 0.0 0.00024 21.4 0.0 1.2 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain DUF3071 PF11268.8 KOO32712.1 - 0.0057 16.7 0.8 0.0057 16.7 0.8 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3071) Methyltransf_2 PF00891.18 KOO32714.1 - 7.7e-16 58.0 0.0 1e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 KOO32714.1 - 3.3e-10 39.8 0.2 6.2e-10 38.9 0.2 1.5 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_23 PF13489.6 KOO32714.1 - 1.5e-06 28.2 0.0 2.2e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO32714.1 - 2.8e-06 28.0 0.0 8.7e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO32714.1 - 3.1e-05 24.6 0.0 9.9e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 KOO32714.1 - 0.0085 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOO32714.1 - 0.01 15.6 0.0 0.046 13.5 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 KOO32714.1 - 0.013 16.1 0.0 0.031 14.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOO32714.1 - 0.05 13.2 0.1 0.77 9.3 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase small domain Ubie_methyltran PF01209.18 KOO32714.1 - 0.076 12.3 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF4200 PF13863.6 KOO32715.1 - 0.077 13.4 5.8 3.1 8.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Asp PF00026.23 KOO32718.1 - 1.5e-25 90.3 0.2 3e-25 89.3 0.2 1.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO32718.1 - 1.8e-07 31.5 6.1 2.4e-06 27.9 1.9 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Peptidase_S15 PF02129.18 KOO32719.1 - 3.1e-37 128.6 0.0 4.4e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 KOO32719.1 - 3.2e-17 63.2 0.0 2.2e-16 60.5 0.0 2.1 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain COPI_assoc PF08507.10 KOO32720.1 - 0.057 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 COPI associated protein Na_H_antiport_2 PF13726.6 KOO32720.1 - 0.13 12.4 0.3 0.13 12.4 0.3 1.8 2 0 0 2 2 2 0 Na+-H+ antiporter family Med3 PF11593.8 KOO32720.1 - 0.45 9.7 12.1 0.56 9.3 12.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal S6PP PF05116.13 KOO32721.1 - 1.5e-16 60.7 0.0 2.1e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 KOO32721.1 - 3.6e-08 33.4 0.0 5.1e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase OATP PF03137.20 KOO32721.1 - 0.036 12.4 0.6 0.089 11.1 0.0 1.8 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Hydrolase PF00702.26 KOO32721.1 - 0.081 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase MTBP_C PF14920.6 KOO32722.1 - 0.58 9.9 8.1 0.73 9.5 8.1 1.1 1 0 0 1 1 1 0 MDM2-binding Exonuc_VII_L PF02601.15 KOO32722.1 - 0.9 9.1 15.8 1 8.9 15.8 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.12 KOO32722.1 - 5.7 5.4 9.9 6.3 5.2 9.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family SBBP PF06739.11 KOO32723.1 - 9.2e-16 57.6 33.5 0.0014 18.6 1.4 7.1 7 0 0 7 7 7 6 Beta-propeller repeat VCBS PF13517.6 KOO32723.1 - 3.5 8.3 20.1 6.5 7.4 0.8 4.3 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TIR_2 PF13676.6 KOO32724.1 - 2.6e-08 34.5 0.0 4.9e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 TIR domain SSF PF00474.17 KOO32724.1 - 0.00028 19.9 1.3 0.00028 19.9 1.3 1.7 2 0 0 2 2 2 1 Sodium:solute symporter family Peptidase_C1 PF00112.23 KOO32725.1 - 0.00021 21.5 0.2 0.67 10.0 0.0 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Rtf2 PF04641.12 KOO32726.1 - 6.8e-41 140.4 0.0 9.3e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger SOUL PF04832.12 KOO32726.1 - 5.4e-05 23.4 0.0 8e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 SOUL heme-binding protein DUF2694 PF10904.8 KOO32726.1 - 0.17 12.0 0.7 0.98 9.5 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2694) UBX PF00789.20 KOO32727.1 - 6.9e-06 26.2 0.0 1.2e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 UBX domain FKBP_C PF00254.28 KOO32730.1 - 5.6e-16 58.7 0.0 8.1e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase ShK PF01549.24 KOO32731.1 - 1.5e-21 76.6 34.2 8.5e-08 32.6 3.5 3.3 3 0 0 3 3 3 3 ShK domain-like UPF0640 PF15114.6 KOO32734.1 - 4.6e-09 36.0 0.0 6.3e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0640 CENP-T_C PF15511.6 KOO32735.1 - 1.2e-08 35.1 0.1 1.4e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KOO32735.1 - 0.00011 22.5 0.1 0.00014 22.1 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 KOO32735.1 - 0.00016 21.7 0.2 0.00023 21.3 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 KOO32735.1 - 0.00069 19.9 0.1 0.0011 19.1 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOO32735.1 - 0.00077 19.8 0.3 0.00086 19.7 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 KOO32735.1 - 0.0088 16.1 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KOO32735.1 - 0.0098 15.9 0.1 0.015 15.3 0.1 1.2 1 0 0 1 1 1 1 Bromodomain associated UPF0137 PF03677.13 KOO32735.1 - 0.16 11.7 0.1 0.2 11.4 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Psb28 PF03912.14 KOO32737.1 - 1.7e-37 127.9 0.0 2e-37 127.7 0.0 1.1 1 0 0 1 1 1 1 Psb28 protein HC2 PF07382.11 KOO32738.1 - 0.1 12.6 53.6 0.15 12.2 53.6 1.2 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 B9-C2 PF07162.11 KOO32739.1 - 6e-45 153.5 0.0 6.9e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein ADH_zinc_N PF00107.26 KOO32740.1 - 6.4e-19 68.2 0.1 1.1e-18 67.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOO32740.1 - 1.1e-14 55.6 0.0 3.7e-14 53.9 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOO32740.1 - 5.5e-13 48.7 0.3 2.4e-12 46.7 0.1 2.1 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 KOO32740.1 - 0.0063 16.0 0.5 0.011 15.2 0.5 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Tho2 PF11262.8 KOO32741.1 - 2.1e-97 326.0 2.4 3.4e-97 325.3 2.4 1.3 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 KOO32741.1 - 1.2e-69 235.6 0.0 5.6e-37 127.7 0.1 3.2 3 0 0 3 3 3 3 THO complex subunit 2 N-terminus Thoc2 PF11732.8 KOO32741.1 - 5.9e-30 103.1 0.3 2.1e-29 101.4 0.3 2.0 1 0 0 1 1 1 1 Transcription- and export-related complex subunit p25-alpha PF05517.12 KOO32742.1 - 0.037 14.2 0.0 2.8 8.1 0.0 2.6 2 0 0 2 2 2 0 p25-alpha TPD52 PF04201.15 KOO32743.1 - 0.014 15.0 12.9 0.08 12.6 0.1 3.5 3 0 0 3 3 3 0 Tumour protein D52 family HALZ PF02183.18 KOO32743.1 - 0.55 10.5 13.4 11 6.4 0.0 5.7 5 0 0 5 5 5 0 Homeobox associated leucine zipper DUF1912 PF08930.10 KOO32743.1 - 7.1 6.9 7.3 19 5.5 0.6 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1912) Na_Ca_ex PF01699.24 KOO32746.1 - 1.2e-28 100.0 38.2 7.2e-15 55.3 16.6 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Glutaredoxin2_C PF04399.13 KOO32747.1 - 3e-27 95.0 0.0 4.2e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin 2, C terminal domain GST_N_3 PF13417.6 KOO32747.1 - 0.00037 20.8 0.1 0.0051 17.2 0.0 2.7 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO32747.1 - 0.0039 17.4 0.0 0.011 16.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 KOO32747.1 - 0.17 12.1 0.1 0.34 11.2 0.1 1.5 1 0 0 1 1 1 0 Glutaredoxin ETC_C1_NDUFA4 PF04800.12 KOO32748.1 - 3.2e-27 94.6 5.0 4.4e-27 94.2 5.0 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Ribonuclease_T2 PF00445.18 KOO32749.1 - 7.4e-09 36.1 0.0 9.4e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family COPI_assoc PF08507.10 KOO32750.1 - 2.6e-12 46.9 1.9 3.2e-12 46.6 1.9 1.1 1 0 0 1 1 1 1 COPI associated protein PGPGW PF09656.10 KOO32750.1 - 1.4 8.5 9.9 53 3.4 11.0 2.7 2 1 0 2 2 2 0 Putative transmembrane protein (PGPGW) AAA_30 PF13604.6 KOO32752.1 - 2e-14 53.8 0.2 2.8e-12 46.8 0.0 2.7 2 1 1 3 3 3 1 AAA domain PIF1 PF05970.14 KOO32752.1 - 1.2e-13 51.0 0.0 2.2e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase AAA_19 PF13245.6 KOO32752.1 - 5.1e-06 26.9 0.0 1.2e-05 25.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOO32752.1 - 0.0022 18.3 0.0 0.0056 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KOO32752.1 - 0.005 16.1 1.0 0.029 13.6 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_6 PF12774.7 KOO32752.1 - 0.047 12.7 0.1 0.074 12.0 0.1 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 KOO32752.1 - 0.13 12.3 0.2 1.4 8.9 0.0 2.5 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Herpes_Helicase PF02689.14 KOO32752.1 - 0.18 9.7 0.0 0.6 8.0 0.0 1.8 2 0 0 2 2 2 0 Helicase Melittin PF01372.17 KOO32753.1 - 0.17 11.9 3.2 12 6.1 0.0 3.0 3 0 0 3 3 3 0 Melittin Pkinase PF00069.25 KOO32754.1 - 1.2e-60 205.2 0.0 3.2e-60 203.7 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain cNMP_binding PF00027.29 KOO32754.1 - 1.8e-55 184.9 0.0 1.4e-18 66.8 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO32754.1 - 2.6e-27 95.7 0.0 5.3e-27 94.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Arabinose_Isome PF02610.15 KOO32754.1 - 0.037 13.2 0.2 0.061 12.5 0.2 1.2 1 0 0 1 1 1 0 L-arabinose isomerase Kinase-like PF14531.6 KOO32754.1 - 0.09 12.1 0.0 0.24 10.7 0.0 1.7 1 1 1 2 2 2 0 Kinase-like MgtE_N PF03448.17 KOO32754.1 - 0.18 12.4 1.5 6.3 7.5 0.0 3.2 3 0 0 3 3 3 0 MgtE intracellular N domain DREV PF05219.12 KOO32755.1 - 0.039 13.1 0.0 0.053 12.6 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase DEAD PF00270.29 KOO32756.1 - 2.2e-45 154.6 0.0 6.4e-45 153.1 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO32756.1 - 1.7e-28 99.1 0.0 3.4e-27 95.0 0.3 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Coa1 PF08695.10 KOO32756.1 - 7.1e-06 25.8 0.1 1.3e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 ResIII PF04851.15 KOO32756.1 - 0.004 17.2 0.0 0.0068 16.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Arm PF00514.23 KOO32757.1 - 3.8e-16 58.5 2.7 5e-09 35.9 0.1 5.1 4 1 1 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KOO32757.1 - 0.00053 20.0 0.2 0.12 12.7 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 KOO32757.1 - 0.0059 17.0 6.2 0.01 16.2 1.8 2.9 1 1 1 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 KOO32757.1 - 0.081 13.5 1.3 0.081 13.5 1.3 3.8 4 2 1 5 5 5 0 HEAT-like repeat Rad60-SLD PF11976.8 KOO32759.1 - 2.9e-06 27.0 0.0 6.4e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOO32759.1 - 0.005 16.6 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family TilS PF09179.11 KOO32759.1 - 0.47 11.0 2.1 5.1 7.7 0.1 3.0 2 1 0 3 3 3 0 TilS substrate binding domain LRR_8 PF13855.6 KOO32760.1 - 3.3e-10 39.6 2.8 0.014 15.2 0.1 4.6 4 1 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 KOO32760.1 - 0.00062 20.1 2.2 0.19 12.2 0.0 4.4 5 1 1 6 6 6 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO32760.1 - 0.35 11.6 8.3 1.1e+02 4.0 0.0 6.8 9 0 0 9 9 9 0 Leucine Rich Repeat 2OG-FeII_Oxy_2 PF13532.6 KOO32762.1 - 6.4e-16 59.1 0.0 8.9e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Filament PF00038.21 KOO32763.1 - 0.2 11.2 11.2 1.5 8.4 1.7 2.4 1 1 1 2 2 2 0 Intermediate filament protein Cytochrom_C552 PF02335.15 KOO32763.1 - 2.5 6.9 9.0 4.1 6.2 9.0 1.3 1 0 0 1 1 1 0 Cytochrome c552 BSMAP PF12280.8 KOO32764.1 - 0.018 15.3 0.1 0.023 14.9 0.1 1.2 1 0 0 1 1 1 0 Brain specific membrane anchored protein Form_Nir_trans PF01226.17 KOO32765.1 - 1.9e-57 194.4 18.2 2.3e-57 194.1 18.2 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter ComS PF17584.2 KOO32766.1 - 0.018 14.6 0.0 0.035 13.6 0.0 1.5 1 0 0 1 1 1 0 Bacillus competence protein S Nucleotid_trans PF03407.16 KOO32767.1 - 2.2e-10 40.9 0.0 3.9e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Aminotran_4 PF01063.19 KOO32771.1 - 1.2e-26 94.0 0.0 6.8e-25 88.2 0.0 2.1 2 0 0 2 2 2 2 Amino-transferase class IV zf-CXXC PF02008.20 KOO32774.1 - 4.7e-12 45.7 19.8 9e-12 44.8 19.8 1.5 1 0 0 1 1 1 1 CXXC zinc finger domain LRR_4 PF12799.7 KOO32775.1 - 1.7e-18 66.4 6.7 7.7e-06 26.2 0.2 4.7 3 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO32775.1 - 1.1e-13 50.7 2.3 0.00092 18.9 0.1 3.4 3 0 0 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 KOO32775.1 - 2.1e-05 24.1 0.3 0.072 12.6 0.0 2.6 2 1 0 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 KOO32775.1 - 0.036 14.1 0.0 3.3 8.0 0.0 3.9 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 KOO32775.1 - 0.13 12.9 2.5 1.1e+02 4.0 0.2 5.0 5 1 0 5 5 5 0 Leucine Rich Repeat COG4 PF08318.12 KOO32777.1 - 1.8e-11 43.7 0.0 6.1e-11 42.0 0.0 1.8 1 1 0 1 1 1 1 COG4 transport protein RINT1_TIP1 PF04437.13 KOO32777.1 - 6.5e-05 22.0 0.1 0.00012 21.1 0.1 1.4 1 0 0 1 1 1 1 RINT-1 / TIP-1 family Spc7 PF08317.11 KOO32777.1 - 0.086 11.7 1.3 0.21 10.4 1.3 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein Vitellogenin_N PF01347.22 KOO32778.1 - 0.18 10.2 0.0 0.26 9.6 0.0 1.1 1 0 0 1 1 1 0 Lipoprotein amino terminal region PKD_channel PF08016.12 KOO32780.1 - 2.5e-23 82.4 13.1 1.6e-21 76.5 12.8 2.9 3 0 0 3 3 3 2 Polycystin cation channel Ion_trans PF00520.31 KOO32780.1 - 1.6e-11 43.9 15.4 1.6e-11 43.9 15.4 2.1 2 0 0 2 2 2 2 Ion transport protein Glyco_transf_8 PF01501.20 KOO32781.1 - 7.3e-10 38.8 0.1 6.1e-09 35.8 0.1 2.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 LNS2 PF08235.13 KOO32782.1 - 0.15 11.6 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) Chorein_N PF12624.7 KOO32783.1 - 3.5e-23 81.9 0.0 5e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 T4_deiodinase PF00837.17 KOO32784.1 - 1e-26 93.7 0.1 1.3e-26 93.4 0.1 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase DUF282 PF03380.14 KOO32784.1 - 0.096 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF282 Glycos_transf_2 PF00535.26 KOO32785.1 - 1.1e-23 83.9 0.0 1.4e-11 44.5 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KOO32785.1 - 1.1e-12 48.3 0.4 3.1e-05 24.0 0.4 3.1 2 1 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KOO32785.1 - 3.3e-08 33.3 0.0 0.00017 21.2 0.0 3.1 2 1 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 KOO32785.1 - 0.021 14.7 0.2 0.021 14.7 0.2 2.2 2 1 0 2 2 2 0 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 KOO32785.1 - 0.027 14.0 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 Ion_trans PF00520.31 KOO32786.1 - 1.7e-204 675.8 59.1 5.9e-56 189.4 5.8 4.1 4 0 0 4 4 4 4 Ion transport protein TPR_10 PF13374.6 KOO32786.1 - 7.8e-24 82.8 5.5 1.4e-08 34.3 0.5 4.0 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO32786.1 - 1e-23 83.4 2.1 4e-11 43.0 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat PKD_channel PF08016.12 KOO32786.1 - 5e-10 38.6 72.7 2.1e-05 23.4 10.8 8.3 7 2 2 9 9 9 7 Polycystin cation channel GPHH PF16905.5 KOO32786.1 - 3.3e-06 26.8 0.0 7.1e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated TPR_7 PF13176.6 KOO32786.1 - 0.00016 21.4 0.5 1.6 9.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO32786.1 - 0.0067 17.2 1.6 9.2 7.4 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO32786.1 - 0.0097 15.7 0.0 18 5.3 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO32786.1 - 0.015 15.8 0.1 0.75 10.4 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO32786.1 - 0.065 13.4 0.1 9.5 6.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO32786.1 - 0.15 12.7 3.0 4.4 8.0 0.7 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO32786.1 - 0.69 10.7 2.6 1.9e+02 3.1 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat UL45 PF05473.12 KOO32786.1 - 3.2 7.3 4.2 4.4 6.9 0.1 3.1 4 0 0 4 4 4 0 UL45 protein, carbohydrate-binding C-type lectin-like CLASP_N PF12348.8 KOO32787.1 - 1.4e-07 31.3 0.2 5.8e-07 29.3 0.0 2.1 3 0 0 3 3 3 1 CLASP N terminal PseudoU_synth_1 PF01416.20 KOO32787.1 - 0.083 13.4 2.0 0.37 11.3 0.6 2.5 2 0 0 2 2 2 0 tRNA pseudouridine synthase HEAT PF02985.22 KOO32787.1 - 0.11 12.8 1.1 4.2 7.9 0.1 3.5 2 0 0 2 2 2 0 HEAT repeat DUF3869 PF12985.7 KOO32787.1 - 0.38 11.2 6.9 8 6.9 6.9 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3869) Chon_Sulph_att PF06566.11 KOO32787.1 - 0.49 10.2 0.0 0.49 10.2 0.0 3.5 4 1 0 4 4 4 0 Chondroitin sulphate attachment domain Neur_chan_memb PF02932.16 KOO32788.1 - 3.4e-05 24.0 5.7 8e-05 22.8 3.6 2.0 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DUF179 PF02622.15 KOO32789.1 - 6.7e-18 65.2 0.1 2.7e-17 63.2 0.1 1.9 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 Sugar_tr PF00083.24 KOO32791.1 - 1.8e-80 271.1 13.7 3.2e-80 270.2 13.7 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO32791.1 - 1.5e-14 53.7 62.2 7.9e-13 48.0 39.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily p25-alpha PF05517.12 KOO32792.1 - 0.00034 20.8 0.0 0.0062 16.7 0.0 2.7 3 1 1 4 4 4 1 p25-alpha Head-tail_con PF12236.8 KOO32792.1 - 0.043 12.3 0.3 0.066 11.6 0.3 1.2 1 0 0 1 1 1 0 Bacteriophage head to tail connecting protein Mis12 PF05859.12 KOO32793.1 - 0.15 12.1 0.3 0.67 10.0 0.1 2.2 2 1 0 2 2 2 0 Mis12 protein FliG_N PF14842.6 KOO32793.1 - 0.34 11.5 9.8 0.56 10.8 3.2 3.9 4 0 0 4 4 4 0 FliG N-terminal domain Neur_chan_memb PF02932.16 KOO32794.1 - 1.2e-06 28.8 0.4 2e-06 28.0 0.4 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region EamA PF00892.20 KOO32794.1 - 7.7e-05 22.9 36.1 0.00032 20.9 6.8 3.9 4 0 0 4 4 4 2 EamA-like transporter family SLC35F PF06027.12 KOO32794.1 - 0.0013 18.3 0.1 0.0013 18.3 0.1 1.7 2 0 0 2 2 2 1 Solute carrier family 35 CRT-like PF08627.10 KOO32794.1 - 0.0043 16.1 0.3 0.0071 15.3 0.3 1.2 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like Pkinase PF00069.25 KOO32795.1 - 2.8e-48 164.6 0.0 5.8e-48 163.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain ABC_tran PF00005.27 KOO32795.1 - 2.6e-31 109.0 0.0 1.2e-19 71.2 0.0 3.0 2 1 0 2 2 2 2 ABC transporter Pkinase_Tyr PF07714.17 KOO32795.1 - 4.4e-24 85.2 0.0 7.2e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase AAA_21 PF13304.6 KOO32795.1 - 1.1e-11 45.1 0.1 0.0079 16.0 0.0 3.3 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO32795.1 - 5.5e-06 26.0 0.0 0.021 14.3 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain Kinase-like PF14531.6 KOO32795.1 - 5.4e-05 22.6 0.0 9.9e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like AAA_23 PF13476.6 KOO32795.1 - 0.0012 19.4 2.4 0.14 12.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KOO32795.1 - 0.017 14.8 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 KOO32795.1 - 0.025 14.8 0.0 0.2 11.9 0.0 2.5 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 KOO32795.1 - 0.038 14.1 0.1 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_22 PF13401.6 KOO32795.1 - 0.097 12.9 0.0 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 KOO32795.1 - 0.14 11.8 2.6 0.2 11.4 0.1 2.2 3 0 0 3 3 3 0 AAA ATPase domain p450 PF00067.22 KOO32796.1 - 1.1e-58 199.1 0.0 1.4e-58 198.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HCO3_cotransp PF00955.21 KOO32797.1 - 7.6e-86 288.9 4.2 3.4e-46 158.1 0.0 2.3 1 1 1 2 2 2 2 HCO3- transporter family LRR_6 PF13516.6 KOO32798.1 - 1.5e-59 193.0 43.4 0.00014 21.7 0.0 16.7 16 0 0 16 16 15 14 Leucine Rich repeat LRR_8 PF13855.6 KOO32798.1 - 2.1e-07 30.6 18.6 0.12 12.2 0.2 8.5 5 3 5 10 10 9 3 Leucine rich repeat LRR_1 PF00560.33 KOO32798.1 - 4e-06 26.6 0.4 2.9e+02 2.7 0.0 9.3 11 1 0 11 11 8 0 Leucine Rich Repeat NACHT PF05729.12 KOO32798.1 - 5e-06 26.5 0.0 1.8e-05 24.7 0.1 2.0 2 0 0 2 2 2 1 NACHT domain LRR_4 PF12799.7 KOO32798.1 - 6.5e-06 26.4 27.1 0.097 13.1 0.2 9.0 5 4 7 12 12 12 4 Leucine Rich repeats (2 copies) AAA_25 PF13481.6 KOO32798.1 - 0.0062 16.1 3.6 0.0085 15.7 0.2 3.1 2 1 1 3 3 3 1 AAA domain NUDIX PF00293.28 KOO32798.1 - 0.0064 16.5 0.2 0.024 14.7 0.2 2.0 1 0 0 1 1 1 1 NUDIX domain CheY-binding PF09078.11 KOO32798.1 - 0.052 13.7 0.1 0.14 12.3 0.1 1.7 1 0 0 1 1 1 0 CheY binding EcKinase PF02958.20 KOO32798.1 - 0.072 12.4 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Kdo PF06293.14 KOO32798.1 - 0.077 12.3 0.5 0.27 10.6 0.2 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_16 PF13191.6 KOO32798.1 - 0.077 13.4 0.1 0.077 13.4 0.1 4.1 4 0 0 4 4 4 0 AAA ATPase domain RIO1 PF01163.22 KOO32798.1 - 0.088 12.4 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 RIO1 family AAA_14 PF13173.6 KOO32798.1 - 0.17 11.9 0.0 5.8 7.0 0.0 3.1 2 1 1 3 3 3 0 AAA domain Tudor_RapA PF18337.1 KOO32799.1 - 0.028 14.6 0.4 1.7 8.9 0.2 2.7 2 0 0 2 2 2 0 RapA N-terminal Tudor like domain Seryl_tRNA_N PF02403.22 KOO32799.1 - 6.2 7.1 18.9 0.26 11.5 11.4 2.6 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ECH_1 PF00378.20 KOO32800.1 - 2.9e-09 36.6 0.6 3.1e-09 36.5 0.6 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 KOO32800.1 - 0.017 15.1 0.8 0.048 13.6 0.3 1.8 2 0 0 2 2 2 0 Peptidase family S49 Plectin PF00681.20 KOO32800.1 - 0.069 13.0 0.1 0.74 9.7 0.0 2.2 2 0 0 2 2 2 0 Plectin repeat DUF4597 PF15366.6 KOO32803.1 - 0.19 11.5 0.4 0.81 9.5 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) Arm PF00514.23 KOO32804.1 - 9.5e-29 98.5 16.1 6.7e-05 22.8 0.0 10.5 9 1 1 10 10 10 8 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO32804.1 - 0.00037 20.5 0.0 22 5.1 0.0 4.9 4 1 1 5 5 5 2 Spinocerebellar ataxia type 10 protein domain DUF5578 PF17741.1 KOO32804.1 - 0.00091 18.7 0.4 0.38 10.1 0.0 3.8 2 2 2 4 4 4 1 Family of unknown function (DUF5578) DUF3220 PF11516.8 KOO32804.1 - 0.0068 16.6 0.2 0.017 15.4 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3120) V-ATPase_H_C PF11698.8 KOO32804.1 - 0.018 15.2 0.0 0.33 11.1 0.0 2.5 2 0 0 2 2 2 0 V-ATPase subunit H HEAT PF02985.22 KOO32804.1 - 0.03 14.6 1.8 26 5.4 0.0 5.5 5 0 0 5 5 5 0 HEAT repeat 2OG-FeII_Oxy_3 PF13640.6 KOO32805.1 - 7.3e-10 39.6 0.0 8.9e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO32805.1 - 0.00022 21.7 0.0 0.00027 21.4 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1765 PF08578.10 KOO32806.1 - 7.8e-11 42.5 0.2 1.5e-10 41.6 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) B56 PF01603.20 KOO32806.1 - 3.4e-05 23.0 0.5 5e-05 22.4 0.5 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Phage_int_SAM_2 PF12834.7 KOO32808.1 - 0.03 15.0 1.6 75 4.1 0.0 4.7 2 1 5 7 7 7 0 Phage integrase, N-terminal Tubulin PF00091.25 KOO32813.1 - 1.2e-66 224.7 0.0 2.2e-66 223.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOO32813.1 - 1e-39 135.6 0.1 1.6e-39 135.0 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KOO32813.1 - 0.00038 20.7 0.0 0.00092 19.5 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 KOO32813.1 - 0.0048 16.1 0.1 0.013 14.7 0.0 1.7 2 0 0 2 2 2 1 Tubulin like Rib_recp_KP_reg PF05104.12 KOO32814.1 - 3 8.8 13.8 3.8 8.5 13.8 1.1 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region PolyA_pol PF01743.20 KOO32815.1 - 0.069 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Poly A polymerase head domain cobW PF02492.19 KOO32816.1 - 3.2e-46 157.1 0.1 4.8e-46 156.6 0.0 1.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KOO32816.1 - 0.00057 19.7 0.7 0.0018 18.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KOO32816.1 - 0.0011 18.9 0.5 1 9.2 0.2 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOO32816.1 - 0.0022 17.5 0.5 0.13 11.7 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOO32816.1 - 0.0038 16.8 0.1 0.0087 15.6 0.0 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_33 PF13671.6 KOO32816.1 - 0.0058 16.8 0.7 0.039 14.1 0.7 2.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOO32816.1 - 0.0072 16.1 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 KOO32816.1 - 0.01 15.8 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 KOO32816.1 - 0.016 15.6 2.5 0.11 12.9 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KOO32816.1 - 0.017 15.4 0.0 0.037 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 KOO32816.1 - 0.044 13.7 0.4 0.14 12.0 0.2 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.23 KOO32816.1 - 0.048 13.7 0.0 0.12 12.5 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 KOO32816.1 - 0.07 12.9 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 KOO32816.1 - 0.12 12.9 0.1 0.19 12.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 KOO32816.1 - 0.26 10.2 3.3 3.5 6.5 0.2 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PIN_10 PF18478.1 KOO32817.1 - 0.12 12.6 0.1 2 8.7 0.1 2.7 2 0 0 2 2 2 0 PIN like domain EF-hand_1 PF00036.32 KOO32817.1 - 0.13 11.8 0.0 0.33 10.6 0.0 1.7 1 0 0 1 1 1 0 EF hand SCAI PF12070.8 KOO32819.1 - 4.5e-97 326.1 2.7 1.4e-40 139.7 4.9 3.0 3 0 0 3 3 3 3 Protein SCAI CAP_N PF01213.19 KOO32819.1 - 0.0047 16.5 2.5 0.0089 15.5 2.5 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 KOO32819.1 - 0.045 13.8 0.9 0.084 12.9 0.9 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF3040 PF11239.8 KOO32819.1 - 0.083 13.2 7.0 0.11 12.8 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) PRIMA1 PF16101.5 KOO32819.1 - 0.58 10.2 9.0 1.4 9.0 9.0 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 fn3 PF00041.21 KOO32820.1 - 5e-07 30.0 0.0 1.1e-06 28.9 0.0 1.6 1 1 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KOO32820.1 - 0.09 13.4 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain LRR_6 PF13516.6 KOO32822.1 - 1.9e-10 39.9 1.3 0.027 14.5 0.0 4.6 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.7 KOO32822.1 - 0.005 17.2 0.0 0.062 13.8 0.4 2.5 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) RNase_T PF00929.24 KOO32823.1 - 4.7e-19 69.5 0.0 6e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Exonuclease DNA_ligase_A_M PF01068.21 KOO32823.1 - 0.21 11.2 0.0 1.2 8.8 0.0 1.9 2 0 0 2 2 2 0 ATP dependent DNA ligase domain DUF2476 PF10630.9 KOO32824.1 - 0.0021 18.2 0.9 0.0025 18.0 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2476) RRP14 PF15459.6 KOO32824.1 - 0.13 12.8 2.9 0.14 12.8 0.1 2.1 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 M16C_assoc PF08367.11 KOO32825.1 - 5.4e-50 169.9 0.0 8e-50 169.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 KOO32825.1 - 7.9e-27 94.4 0.0 3.5e-23 82.6 0.0 3.2 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOO32825.1 - 2.3e-06 27.6 0.1 6.8e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) EF-hand_1 PF00036.32 KOO32827.1 - 6e-30 100.5 14.0 4.3e-09 35.3 3.9 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO32827.1 - 1.6e-28 98.9 4.5 4.2e-14 52.7 1.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO32827.1 - 3.6e-26 90.8 7.9 5.3e-15 55.0 2.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO32827.1 - 9.7e-24 81.2 7.6 1.5e-05 24.6 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO32827.1 - 1.4e-20 71.8 11.0 2.8e-05 23.4 2.7 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KOO32827.1 - 9.1e-10 38.7 0.1 1.4e-05 25.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO32827.1 - 3.6e-05 24.1 0.2 0.068 13.5 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO32827.1 - 0.0013 18.7 1.8 1.3 9.0 0.0 2.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Glycos_trans_3N PF02885.17 KOO32827.1 - 0.043 13.7 1.6 0.68 9.8 0.5 2.8 2 1 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Caleosin PF05042.13 KOO32827.1 - 0.047 13.6 2.1 4.5 7.2 0.2 3.2 1 1 1 3 3 3 0 Caleosin related protein PMBR PF09373.10 KOO32827.1 - 0.16 12.2 0.0 19 5.6 0.0 3.2 4 0 0 4 4 4 0 Pseudomurein-binding repeat DUF1529 PF07485.11 KOO32827.1 - 0.18 11.7 0.4 1.3 8.9 0.1 2.2 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1259) DUF1296 PF06972.11 KOO32827.1 - 0.46 10.7 2.0 12 6.1 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) Dockerin_1 PF00404.18 KOO32827.1 - 0.57 10.4 1.9 33 4.8 0.1 2.8 2 1 0 2 2 2 0 Dockerin type I domain SNARE_assoc PF09335.11 KOO32828.1 - 3.4e-20 72.7 11.8 3.4e-20 72.7 11.8 1.6 2 0 0 2 2 2 1 SNARE associated Golgi protein Mg_trans_NIPA PF05653.14 KOO32829.1 - 7e-34 117.3 12.8 1.7e-33 116.0 12.8 1.5 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KOO32829.1 - 7e-08 32.7 5.3 7e-08 32.7 5.3 3.2 2 2 0 2 2 2 1 EamA-like transporter family TMEM234 PF10639.9 KOO32829.1 - 0.03 14.4 0.4 0.03 14.4 0.4 1.9 2 0 0 2 2 2 0 Putative transmembrane family 234 DUF1634 PF07843.11 KOO32829.1 - 0.097 12.8 5.3 0.12 12.5 0.7 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF1634) Agenet PF05641.12 KOO32830.1 - 9.1e-17 61.3 2.0 1.2e-12 48.1 0.1 2.4 2 0 0 2 2 2 2 Agenet domain DUF4129 PF13559.6 KOO32830.1 - 0.14 12.4 3.4 0.52 10.6 3.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4129) zf-CXXC PF02008.20 KOO32831.1 - 8.1e-06 25.8 4.7 8.1e-06 25.8 4.7 2.1 2 0 0 2 2 2 1 CXXC zinc finger domain zf-CW PF07496.15 KOO32831.1 - 0.00066 19.7 0.6 0.0024 17.9 0.6 2.0 1 0 0 1 1 1 1 CW-type Zinc Finger JmjC PF02373.22 KOO32831.1 - 0.0077 16.7 0.0 0.021 15.3 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 KOO32831.1 - 0.071 13.0 0.1 0.071 13.0 0.1 2.3 2 0 0 2 2 2 0 PHD-finger WWE PF02825.20 KOO32833.1 - 1.9e-15 57.2 0.1 8.2e-05 23.1 0.0 3.4 2 1 1 3 3 3 3 WWE domain Epimerase PF01370.21 KOO32833.1 - 1.8e-12 47.3 0.0 6.3e-12 45.5 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 KOO32833.1 - 3.9e-08 32.8 0.0 5.9e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 KOO32833.1 - 1.9e-07 30.4 0.0 2.8e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KOO32833.1 - 0.00072 19.5 0.0 0.0018 18.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding PARP PF00644.20 KOO32833.1 - 0.0045 16.6 0.2 0.069 12.7 0.2 2.2 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain LRR_8 PF13855.6 KOO32836.1 - 9.9e-07 28.4 0.1 1.8e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KOO32836.1 - 1e-05 25.8 0.0 2.3e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) TRP PF06011.12 KOO32836.1 - 0.023 13.4 0.4 0.023 13.4 0.4 3.6 1 1 3 4 4 4 0 Transient receptor potential (TRP) ion channel LRR_6 PF13516.6 KOO32836.1 - 0.038 14.0 0.0 1.4 9.2 0.0 2.9 2 0 0 2 2 2 0 Leucine Rich repeat PDZ_3 PF17815.1 KOO32836.1 - 0.069 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 PDZ domain LRR_1 PF00560.33 KOO32836.1 - 0.11 13.1 0.3 1.4 9.8 0.0 2.8 3 0 0 3 3 3 0 Leucine Rich Repeat Mpv17_PMP22 PF04117.12 KOO32837.1 - 8.3e-14 51.6 2.1 8.3e-14 51.6 2.1 1.7 2 0 0 2 2 2 1 Mpv17 / PMP22 family TPR_12 PF13424.6 KOO32838.1 - 2e-10 40.8 3.9 2e-10 40.8 3.9 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF4131 PF13567.6 KOO32838.1 - 0.023 14.4 0.1 0.049 13.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) TPR_2 PF07719.17 KOO32838.1 - 0.6 10.4 6.2 10 6.5 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO32838.1 - 0.72 10.0 7.0 0.38 10.9 0.2 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Leo1 PF04004.13 KOO32839.1 - 3.8e-38 130.9 1.4 3.8e-38 130.9 1.4 1.7 2 0 0 2 2 2 1 Leo1-like protein Dynamin_N PF00350.23 KOO32840.1 - 0.078 13.0 0.6 0.13 12.3 0.6 1.4 1 0 0 1 1 1 0 Dynamin family Type_III_YscX PF09474.10 KOO32841.1 - 7.6 6.9 10.4 14 6.0 0.0 3.5 3 0 0 3 3 3 0 Type III secretion system YscX (type_III_YscX) UCH PF00443.29 KOO32844.1 - 7.7e-34 117.3 0.0 1e-33 116.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KOO32844.1 - 1e-11 44.9 1.7 2.5e-11 43.7 1.7 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 KOO32844.1 - 0.0087 15.7 0.1 0.15 11.6 0.0 2.2 1 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Ribosomal_S4e PF00900.20 KOO32844.1 - 0.042 13.8 0.1 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 Ribosomal family S4e zf-C3HC4 PF00097.25 KOO32846.1 - 3e-09 36.6 14.5 4.9e-09 35.9 14.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO32846.1 - 3.4e-09 36.4 13.5 5.2e-09 35.8 13.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO32846.1 - 1.3e-08 34.6 14.6 2.1e-08 33.9 14.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO32846.1 - 1.1e-07 31.8 13.1 2.3e-07 30.7 13.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KOO32846.1 - 1.4e-07 31.5 12.4 2.5e-07 30.7 12.4 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING U-box PF04564.15 KOO32846.1 - 7.2e-07 29.3 0.1 2.1e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 U-box domain zf-RING_5 PF14634.6 KOO32846.1 - 1.4e-06 28.1 13.8 2.5e-06 27.3 13.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KOO32846.1 - 7.5e-06 26.2 14.1 1.4e-05 25.4 14.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_6 PF14835.6 KOO32846.1 - 7.1e-05 22.6 5.2 0.00013 21.7 5.2 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.8 KOO32846.1 - 7.3e-05 22.5 6.8 0.00014 21.6 6.8 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 KOO32846.1 - 0.0053 16.9 9.3 0.009 16.1 9.3 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 KOO32846.1 - 0.007 16.6 10.8 0.016 15.5 10.8 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KOO32846.1 - 0.016 15.0 13.0 0.083 12.8 13.5 1.8 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KOO32846.1 - 0.036 13.9 16.3 0.37 10.6 16.9 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 KOO32846.1 - 0.07 13.2 3.2 0.12 12.4 3.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_5 PF17121.5 KOO32846.1 - 0.17 11.8 9.7 0.6 10.0 9.7 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 KOO32846.1 - 0.87 9.4 12.3 1.4 8.7 12.3 1.3 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger GST_N_3 PF13417.6 KOO32848.1 - 5.5e-15 55.5 0.0 1.5e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO32848.1 - 1.9e-12 47.3 0.0 3.8e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO32848.1 - 2.9e-10 40.0 0.2 6.9e-10 38.8 0.2 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOO32848.1 - 6e-08 32.8 0.0 1.1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 KOO32848.1 - 3.4e-07 30.8 0.0 6.8e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOO32848.1 - 9e-05 22.6 0.0 0.00019 21.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 KOO32848.1 - 0.0043 17.2 0.0 0.0075 16.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin GST_N PF02798.20 KOO32848.1 - 0.0072 16.6 0.0 0.018 15.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain HEAT_PBS PF03130.16 KOO32848.1 - 7.7 7.5 6.6 35 5.5 0.1 3.7 3 1 0 3 3 3 0 PBS lyase HEAT-like repeat rve PF00665.26 KOO32849.1 - 0.0028 17.8 0.0 0.0085 16.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Iso_dh PF00180.20 KOO32850.1 - 5e-116 387.6 0.0 5.7e-116 387.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Laminin_I PF06008.14 KOO32851.1 - 0.00027 20.7 4.6 0.00027 20.7 4.6 1.6 2 0 0 2 2 2 1 Laminin Domain I Fib_alpha PF08702.10 KOO32851.1 - 0.02 15.1 2.9 0.038 14.2 2.9 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF507 PF04368.13 KOO32851.1 - 0.053 13.5 3.1 3 7.7 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF507) DivIC PF04977.15 KOO32851.1 - 0.35 10.7 0.1 0.35 10.7 0.1 2.6 2 1 1 3 3 3 0 Septum formation initiator Jnk-SapK_ap_N PF09744.9 KOO32851.1 - 4.8 7.4 14.5 0.24 11.6 7.1 1.9 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 PP2C PF00481.21 KOO32852.1 - 1.7e-15 57.4 0.1 1.9e-15 57.2 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO32852.1 - 0.00021 21.3 0.1 0.00027 20.9 0.1 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) LRR_6 PF13516.6 KOO32853.1 - 1.7e-42 139.8 12.5 0.00012 21.9 0.0 8.8 8 0 0 8 8 8 8 Leucine Rich repeat LRR_4 PF12799.7 KOO32853.1 - 0.0028 18.0 6.6 35 5.0 1.0 5.3 3 3 1 5 5 5 2 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.12 KOO32853.1 - 0.039 14.2 1.8 30 5.0 0.1 4.1 3 1 1 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding TRL PF13146.6 KOO32853.1 - 0.37 11.1 3.0 6.4 7.1 0.0 3.5 3 1 1 4 4 4 0 TRL-like protein family CoatB PF10389.9 KOO32853.1 - 1.7 8.6 11.6 60 3.6 0.1 5.3 5 1 1 6 6 6 0 Bacteriophage coat protein B Bromo_TP PF07524.13 KOO32854.1 - 0.11 12.6 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 Bromodomain associated SAP PF02037.27 KOO32855.1 - 9.2e-06 25.3 0.1 1.5e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 SAP domain Staph_haemo PF05480.11 KOO32855.1 - 0.092 12.5 1.4 0.24 11.2 1.4 1.7 1 0 0 1 1 1 0 Staphylococcus haemolytic protein PDZ PF00595.24 KOO32856.1 - 6.3e-05 23.2 0.0 0.00013 22.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO32856.1 - 0.0002 21.1 0.1 0.00051 19.8 0.1 1.7 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO32856.1 - 0.0011 19.2 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Smr PF01713.21 KOO32857.1 - 3.5e-10 40.1 1.1 5.6e-10 39.5 1.1 1.3 1 0 0 1 1 1 1 Smr domain PDZ_6 PF17820.1 KOO32858.1 - 1.6e-05 24.6 0.0 4.1e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain IQ PF00612.27 KOO32858.1 - 0.00012 21.5 8.9 0.054 13.3 0.1 3.3 3 0 0 3 3 3 2 IQ calmodulin-binding motif PDZ PF00595.24 KOO32858.1 - 0.018 15.4 0.1 0.044 14.1 0.1 1.6 1 0 0 1 1 1 0 PDZ domain Glyco_transf_20 PF00982.21 KOO32859.1 - 2.3e-133 445.3 0.0 1.6e-132 442.6 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOO32859.1 - 1.7e-56 190.9 0.0 1.3e-25 89.9 0.0 4.2 3 1 1 4 4 4 4 Trehalose-phosphatase MSSP PF03940.13 KOO32859.1 - 0.061 12.9 4.4 0.15 11.6 4.4 1.6 1 0 0 1 1 1 0 Male specific sperm protein Spore-coat_CotD PF11122.8 KOO32859.1 - 2.9 8.8 4.0 8.7 7.2 4.0 1.8 1 0 0 1 1 1 0 Inner spore coat protein D RVT_2 PF07727.14 KOO32862.1 - 1.2e-24 87.3 0.0 2.6e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KOO32862.1 - 4.9e-10 39.6 0.1 2.2e-09 37.6 0.1 2.2 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 KOO32862.1 - 2.1e-06 27.5 0.0 5.8e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain DUF3466 PF11949.8 KOO32862.1 - 0.056 12.0 0.0 0.089 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3466) DUF737 PF05300.11 KOO32862.1 - 6.7 7.0 8.3 3.3 8.0 4.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF737) Sel1 PF08238.12 KOO32863.1 - 3.1e-67 221.5 68.5 5.8e-07 30.0 0.8 11.7 11 0 0 11 11 11 11 Sel1 repeat U-box PF04564.15 KOO32863.1 - 3.6e-16 59.1 0.0 5.3e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO32863.1 - 0.00036 20.3 0.0 0.00094 18.9 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit BUD22 PF09073.10 KOO32863.1 - 0.029 13.7 24.8 0.047 13.0 24.8 1.2 1 0 0 1 1 1 0 BUD22 AmpE PF17113.5 KOO32863.1 - 0.069 12.5 3.7 15 4.8 0.0 4.3 1 1 6 7 7 7 0 Regulatory signalling modulator protein AmpE SAPS PF04499.15 KOO32863.1 - 9.3 4.9 11.1 18 3.9 11.2 1.4 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein EF-hand_6 PF13405.6 KOO32864.1 - 2.1e-25 86.4 10.6 1.3e-06 27.8 0.0 6.3 6 0 0 6 6 6 4 EF-hand domain EF-hand_7 PF13499.6 KOO32864.1 - 8e-25 87.1 12.0 6.8e-09 36.1 1.5 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO32864.1 - 5.4e-24 81.9 12.5 1.6e-05 24.1 0.0 6.1 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO32864.1 - 3.5e-15 55.6 9.6 4.2e-06 26.5 0.8 4.9 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO32864.1 - 9.9e-14 50.1 15.2 0.0016 17.8 0.7 4.8 4 0 0 4 4 4 4 EF hand Caleosin PF05042.13 KOO32864.1 - 0.00027 20.9 2.1 2.8 7.9 0.0 3.9 3 1 1 4 4 4 2 Caleosin related protein EF-hand_9 PF14658.6 KOO32864.1 - 0.0038 17.5 0.4 14 6.1 0.0 3.9 4 0 0 4 4 4 1 EF-hand domain EF-hand_11 PF08976.11 KOO32864.1 - 0.042 14.7 0.0 0.75 10.7 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 KOO32864.1 - 0.2 11.6 3.0 29 4.7 0.1 3.8 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand TIG PF01833.24 KOO32865.1 - 5.3e-94 308.5 71.4 3.7e-09 36.5 0.0 23.9 23 2 0 23 23 23 20 IPT/TIG domain Anth_Ig PF05587.13 KOO32865.1 - 5.1e-11 42.8 0.0 0.34 11.2 0.0 8.9 11 0 0 11 11 11 3 Anthrax receptor extracellular domain Myosin_head PF00063.21 KOO32866.1 - 9.6e-188 625.6 0.0 1.2e-187 625.3 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) RUN PF02759.19 KOO32866.1 - 3.9e-19 68.9 0.1 1.1e-18 67.4 0.1 1.9 1 0 0 1 1 1 1 RUN domain AAA_16 PF13191.6 KOO32866.1 - 0.023 15.1 0.1 0.12 12.8 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Sad1_UNC PF07738.13 KOO32867.1 - 4.2e-22 78.6 0.0 5.9e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.25 KOO32867.1 - 0.0038 17.3 0.0 0.0082 16.3 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain VirC1 PF07015.11 KOO32867.1 - 0.0092 15.3 0.2 0.016 14.6 0.2 1.3 1 0 0 1 1 1 1 VirC1 protein Not3 PF04065.15 KOO32869.1 - 0.045 13.2 0.1 0.1 12.0 0.1 1.5 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component Pcc1 PF09341.10 KOO32869.1 - 0.13 12.5 12.0 2.2 8.5 0.1 5.9 6 1 1 7 7 7 0 Transcription factor Pcc1 T3SSipB PF16535.5 KOO32869.1 - 3.3 8.2 7.1 0.41 11.1 1.4 2.3 3 0 0 3 3 3 0 Type III cell invasion protein SipB WD-3 PF09765.9 KOO32870.1 - 9.2e-59 199.1 0.0 1.1e-58 198.9 0.0 1.0 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.8 KOO32870.1 - 1.7e-22 79.4 6.6 2.5e-22 78.8 6.6 1.2 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 KOO32870.1 - 4.2e-05 23.8 7.5 7.1e-05 23.1 7.5 1.4 1 0 0 1 1 1 1 Ring finger domain RINGv PF12906.7 KOO32870.1 - 0.0027 17.8 3.1 0.0051 16.9 3.1 1.5 1 0 0 1 1 1 1 RING-variant domain PHD PF00628.29 KOO32870.1 - 0.0078 16.1 8.0 0.014 15.3 8.0 1.4 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.6 KOO32870.1 - 0.028 14.1 3.4 0.04 13.5 3.4 1.2 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.6 KOO32870.1 - 0.052 13.5 0.6 0.052 13.5 0.6 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-rbx1 PF12678.7 KOO32870.1 - 0.13 12.6 5.3 0.34 11.2 5.3 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain Zf_RING PF16744.5 KOO32870.1 - 0.49 10.6 3.6 1.1 9.4 3.6 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger PHD_4 PF16866.5 KOO32870.1 - 0.82 9.8 6.7 3.2 7.9 1.9 2.4 1 1 1 2 2 2 0 PHD-finger SpoIIE PF07228.12 KOO32871.1 - 6.7e-07 29.4 0.1 2.8e-06 27.4 0.1 2.1 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) Ion_trans PF00520.31 KOO32873.1 - 1.5e-14 53.8 6.6 2.9e-14 52.9 6.6 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO32873.1 - 9.9e-10 38.3 1.6 9.9e-10 38.3 1.6 2.0 2 0 0 2 2 2 1 Ion channel His_Phos_1 PF00300.22 KOO32874.1 - 3.3e-22 79.1 0.0 1.9e-19 70.1 0.0 2.2 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF3253 PF11625.8 KOO32874.1 - 0.064 13.5 0.1 0.18 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3253) Ras PF00071.22 KOO32875.1 - 7.1e-55 185.0 0.7 1.1e-54 184.4 0.7 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO32875.1 - 7e-35 119.9 0.9 2.3e-34 118.2 0.4 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Kelch_3 PF13415.6 KOO32875.1 - 8.8e-29 99.2 9.4 4.6e-10 39.5 0.2 7.6 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO32875.1 - 5e-27 93.7 3.9 1.9e-07 31.0 0.0 7.1 7 1 0 7 7 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO32875.1 - 5.8e-23 80.4 5.1 8.4e-05 22.5 0.0 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 KOO32875.1 - 1.1e-16 60.1 2.5 0.0011 18.5 0.3 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KOO32875.1 - 3.7e-16 58.4 9.5 0.0028 17.6 0.1 7.4 8 1 0 8 8 8 4 Kelch motif Kelch_6 PF13964.6 KOO32875.1 - 7.3e-15 54.6 5.5 0.012 15.9 0.1 6.6 7 1 0 7 7 7 3 Kelch motif Arf PF00025.21 KOO32875.1 - 1.9e-13 50.2 0.2 3.5e-13 49.4 0.2 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family RAG2 PF03089.14 KOO32875.1 - 4.7e-05 22.5 0.7 0.67 8.9 0.1 3.2 3 0 0 3 3 3 2 Recombination activating protein 2 Gtr1_RagA PF04670.12 KOO32875.1 - 7.2e-05 22.3 0.1 0.00011 21.7 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO32875.1 - 7.6e-05 22.8 0.0 0.00014 22.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 KOO32875.1 - 0.0012 18.2 0.2 0.0022 17.3 0.2 1.3 1 0 0 1 1 1 1 Septin SRPRB PF09439.10 KOO32875.1 - 0.0017 17.8 0.1 0.0033 16.9 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KOO32875.1 - 0.0035 16.9 1.1 0.014 15.0 0.2 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain NACHT PF05729.12 KOO32875.1 - 0.022 14.7 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 KOO32875.1 - 0.026 14.0 0.1 0.053 13.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 KOO32875.1 - 0.062 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 KOO32875.1 - 0.062 13.7 0.1 0.18 12.2 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO32875.1 - 0.12 12.7 0.1 0.3 11.5 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 KOO32875.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO32876.1 - 0.0099 16.3 0.3 0.13 12.7 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain Torsin PF06309.11 KOO32876.1 - 0.01 15.9 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 Torsin AAA_22 PF13401.6 KOO32876.1 - 0.018 15.3 0.0 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KOO32876.1 - 0.02 14.7 0.0 0.072 12.8 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA PF00004.29 KOO32876.1 - 0.037 14.5 0.0 0.53 10.7 0.1 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOO32876.1 - 0.14 11.9 0.0 0.38 10.5 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Ribosomal_S21 PF01165.20 KOO32877.1 - 2.4e-08 33.6 8.8 5.2e-08 32.5 8.8 1.6 1 1 0 1 1 1 1 Ribosomal protein S21 SHIPPO-rpt PF07004.12 KOO32878.1 - 0.0093 16.8 0.1 0.045 14.7 0.1 2.3 1 1 0 1 1 1 1 Sperm-tail PG-rich repeat BTB PF00651.31 KOO32879.1 - 6.5e-09 36.0 0.0 1.5e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain PUB_1 PF18486.1 KOO32881.1 - 0.025 14.5 3.2 3.1 7.7 0.2 2.7 2 2 0 2 2 2 0 PNGase/UBA- or UBX-containing domain CTNNBL PF08216.11 KOO32882.1 - 1.2e-32 112.2 0.1 2.4e-32 111.2 0.1 1.6 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear DUF3341 PF11821.8 KOO32883.1 - 0.055 13.1 0.0 0.091 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) EF-hand_6 PF13405.6 KOO32883.1 - 0.072 13.1 0.1 1.4 9.0 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain GST_N_3 PF13417.6 KOO32884.1 - 3.1e-17 62.7 0.0 1.2e-16 60.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO32884.1 - 1.4e-12 47.8 0.0 2.7e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KOO32884.1 - 4.7e-08 33.3 0.0 9.4e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO32884.1 - 4.2e-05 23.5 0.1 0.0001 22.3 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 KOO32884.1 - 0.0019 18.4 0.0 0.0036 17.5 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Phycobilisome PF00502.19 KOO32884.1 - 0.039 13.9 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Phycobilisome protein GST_C_3 PF14497.6 KOO32884.1 - 0.046 13.9 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KOO32884.1 - 0.072 13.8 0.0 0.51 11.1 0.0 2.3 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C PF00043.25 KOO32884.1 - 0.13 12.5 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SMN PF06003.12 KOO32884.1 - 0.18 11.0 0.3 0.28 10.4 0.3 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF1344 PF07076.11 KOO32885.1 - 0.04 13.8 0.1 5.6 7.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) 2OG-FeII_Oxy_3 PF13640.6 KOO32886.1 - 1.6e-06 28.9 0.0 2.9e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO32886.1 - 0.004 17.6 0.0 0.0093 16.4 0.0 1.6 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 KOO32886.1 - 0.0042 16.6 0.0 0.0074 15.8 0.0 1.4 1 0 0 1 1 1 1 Oxygenase, catalysing oxidative methylation of damaged DNA MMR_HSR1 PF01926.23 KOO32887.1 - 2.4e-08 34.1 0.0 5.5e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO32887.1 - 1.7e-05 24.8 0.0 0.00026 20.9 0.0 2.4 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 KOO32887.1 - 0.0027 17.2 0.0 0.005 16.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOO32887.1 - 0.0069 16.4 0.0 0.059 13.4 0.0 2.1 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 KOO32887.1 - 0.013 15.9 0.2 0.031 14.7 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 KOO32887.1 - 0.032 14.7 0.0 0.073 13.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Septin PF00735.18 KOO32887.1 - 0.12 11.6 0.0 29 3.8 0.0 3.0 3 1 1 4 4 4 0 Septin AAA_29 PF13555.6 KOO32887.1 - 0.2 11.4 0.0 1.2 8.9 0.0 2.1 1 1 1 2 2 2 0 P-loop containing region of AAA domain EF-hand_5 PF13202.6 KOO32889.1 - 5.9e-05 22.4 1.0 0.00015 21.1 1.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO32889.1 - 0.00061 19.1 0.6 0.0015 18.0 0.6 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO32889.1 - 0.0038 17.0 0.4 0.0038 17.0 0.4 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO32889.1 - 0.088 13.3 0.2 0.22 12.0 0.2 1.6 1 0 0 1 1 1 0 EF-hand domain pair TPR_1 PF00515.28 KOO32889.1 - 0.46 10.4 3.2 0.41 10.5 1.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO32889.1 - 1.1 9.5 3.4 1.3 9.3 2.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat RRM_1 PF00076.22 KOO32890.1 - 2.4e-07 30.5 0.0 3.6e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_transf_88 PF16849.5 KOO32891.1 - 0.014 14.4 0.8 0.021 13.8 0.8 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 88 HRG PF16954.5 KOO32891.1 - 0.076 13.4 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene DUF3584 PF12128.8 KOO32891.1 - 0.2 9.1 4.9 0.26 8.8 4.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) cNMP_binding PF00027.29 KOO32892.1 - 1.7e-05 24.8 0.0 5.5e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 KOO32892.1 - 0.00021 20.6 4.0 0.00072 18.9 4.0 2.0 1 1 0 1 1 1 1 Ion transport protein AAA_28 PF13521.6 KOO32893.1 - 1.2e-23 84.2 0.7 2.8e-23 82.9 0.0 2.0 3 0 0 3 3 3 1 AAA domain MPS2 PF17060.5 KOO32893.1 - 0.025 13.8 1.7 0.071 12.4 0.0 2.0 2 0 0 2 2 2 0 Monopolar spindle protein 2 Sec2p PF06428.11 KOO32893.1 - 0.031 14.2 0.4 0.031 14.2 0.4 2.0 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p AAA_18 PF13238.6 KOO32893.1 - 0.08 13.5 0.0 0.32 11.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain CAP_N PF01213.19 KOO32893.1 - 0.083 12.4 0.1 0.18 11.2 0.1 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SUKH-4 PF14435.6 KOO32893.1 - 0.21 11.6 3.2 4.9 7.2 0.5 2.3 2 0 0 2 2 2 0 SUKH-4 immunity protein GxGYxYP_C PF14323.6 KOO32894.1 - 3.7e-35 122.0 0.0 5.5e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 GxGYxYP putative glycoside hydrolase C-terminal domain GxGYxYP_N PF16216.5 KOO32894.1 - 1.5e-25 90.7 0.0 2.1e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 GxGYxY sequence motif in domain of unknown function N-terminal MSA-2c PF12238.8 KOO32894.1 - 0.44 10.5 3.0 0.99 9.4 3.0 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF2451 PF10474.9 KOO32896.1 - 2.2e-49 168.4 0.0 5.6e-49 167.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 KOO32896.1 - 1.2e-35 123.3 0.0 1.8e-35 122.6 0.0 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF3510 PF12022.8 KOO32896.1 - 0.16 12.3 0.1 1.2 9.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3510) FlgN PF05130.12 KOO32896.1 - 1.2 9.6 9.6 4.5 7.8 0.0 3.9 4 0 0 4 4 4 0 FlgN protein DUF1138 PF06592.13 KOO32897.1 - 0.021 14.9 0.1 4.7 7.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1138) Methyltransf_21 PF05050.12 KOO32898.1 - 8.2e-08 32.4 0.0 1.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain Toxin_38 PF14866.6 KOO32898.1 - 0.1 12.9 1.0 0.2 11.9 1.0 1.4 1 0 0 1 1 1 0 Potassium channel toxin SAM_MT PF04445.13 KOO32898.1 - 0.2 11.1 0.0 0.35 10.2 0.0 1.3 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase LRR_6 PF13516.6 KOO32899.1 - 3.3e-44 145.2 81.1 0.00028 20.7 0.4 28.2 31 0 0 31 31 31 14 Leucine Rich repeat LRR_4 PF12799.7 KOO32899.1 - 5.9e-16 58.3 28.4 0.39 11.2 0.1 14.9 12 3 3 15 15 15 4 Leucine Rich repeats (2 copies) MFS_1 PF07690.16 KOO32899.1 - 8.3e-15 54.6 81.3 2.2e-06 26.9 8.9 3.6 2 1 1 3 3 3 3 Major Facilitator Superfamily LRR_1 PF00560.33 KOO32899.1 - 5e-11 41.6 12.7 66 4.7 0.1 16.2 22 0 0 22 22 22 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO32899.1 - 9.1e-09 35.0 17.4 11 5.9 0.0 13.6 15 0 0 15 15 15 1 Leucine rich repeat NACHT PF05729.12 KOO32899.1 - 1.3e-05 25.2 1.4 2.7e-05 24.1 0.1 2.0 2 0 0 2 2 2 1 NACHT domain SpoU_sub_bind PF08032.12 KOO32899.1 - 0.0028 17.9 0.5 1e+02 3.2 0.0 6.8 9 0 0 9 9 9 0 RNA 2'-O ribose methyltransferase substrate binding AAA_19 PF13245.6 KOO32899.1 - 0.17 12.2 0.5 0.58 10.5 0.1 2.1 2 0 0 2 2 2 0 AAA domain DUF2202 PF09968.9 KOO32899.1 - 0.35 10.7 1.0 1.5e+02 2.2 0.0 4.1 4 0 0 4 4 4 0 Uncharacterized protein domain (DUF2202) DUF1011 PF06237.12 KOO32899.1 - 1.8 9.0 8.1 13 6.2 1.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) Kinesin PF00225.23 KOO32902.1 - 4.2e-87 292.2 0.2 2.5e-45 154.9 0.0 2.6 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KOO32902.1 - 1.5e-17 63.9 0.0 4.4e-17 62.4 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding IQ PF00612.27 KOO32902.1 - 0.017 14.8 0.1 0.059 13.2 0.1 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Mannosyl_trans3 PF11051.8 KOO32903.1 - 1.1e-06 28.2 0.0 1.4e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.20 KOO32903.1 - 0.049 13.2 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 8 NHL PF01436.21 KOO32904.1 - 6.8e-17 60.6 5.2 0.013 15.5 0.0 6.4 6 0 0 6 6 6 5 NHL repeat DUF5128 PF17170.4 KOO32904.1 - 1.5e-07 30.9 0.6 0.061 12.5 0.1 3.2 2 1 1 3 3 3 3 6-bladed beta-propeller SGL PF08450.12 KOO32904.1 - 4.5e-05 23.2 0.0 0.013 15.1 0.0 2.9 2 2 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region PQQ_3 PF13570.6 KOO32904.1 - 0.00065 20.1 0.3 2.2 8.9 0.1 3.3 3 0 0 3 3 3 2 PQQ-like domain TolB_like PF15869.5 KOO32904.1 - 0.026 13.7 0.0 5.3 6.2 0.0 2.8 1 1 1 3 3 3 0 TolB-like 6-blade propeller-like HoxA13_N PF12284.8 KOO32905.1 - 1.5 9.5 5.7 36 5.0 3.1 2.6 2 0 0 2 2 2 0 Hox protein A13 N terminal Leader_Trp PF08255.11 KOO32906.1 - 0.11 12.5 0.5 0.36 10.9 0.5 1.9 1 0 0 1 1 1 0 Trp-operon Leader Peptide Cupin_8 PF13621.6 KOO32907.1 - 1.3e-31 110.2 0.0 3.9e-31 108.7 0.0 1.7 1 0 0 1 1 1 1 Cupin-like domain Golgin_A5 PF09787.9 KOO32907.1 - 6.7e-11 42.2 4.0 6.7e-11 42.2 4.0 2.2 1 1 1 2 2 2 1 Golgin subfamily A member 5 Cupin_4 PF08007.12 KOO32907.1 - 0.00091 18.8 4.5 0.0013 18.2 0.0 3.0 3 1 0 3 3 3 1 Cupin superfamily protein ubiquitin PF00240.23 KOO32908.1 - 0.00042 20.0 0.0 0.21 11.4 0.0 2.6 2 0 0 2 2 2 2 Ubiquitin family ART PF01129.18 KOO32909.1 - 8.7e-06 25.2 0.0 1.3e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO32909.1 - 0.0012 18.2 0.0 0.86 8.9 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme CCDC106 PF15794.5 KOO32910.1 - 0.022 14.4 5.5 0.034 13.9 5.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 PhaP_Bmeg PF09602.10 KOO32910.1 - 0.041 13.8 2.3 0.065 13.2 2.3 1.3 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) UPF0242 PF06785.11 KOO32910.1 - 0.21 11.7 9.0 0.32 11.1 9.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus STPPase_N PF16891.5 KOO32911.1 - 1.2e-11 44.8 0.0 2.6e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Aa_trans PF01490.18 KOO32912.1 - 8.4e-52 176.2 18.7 9.9e-52 176.0 18.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOO32912.1 - 1.2e-09 37.7 10.9 1.2e-09 37.7 10.9 2.7 3 1 0 3 3 3 1 Tryptophan/tyrosine permease family GTP_EFTU PF00009.27 KOO32913.1 - 4.6e-31 107.9 0.1 1.5e-30 106.2 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KOO32913.1 - 2.6e-24 85.3 1.2 5.6e-24 84.3 0.1 2.0 2 0 0 2 2 2 1 Translation-initiation factor 2 IF2_N PF04760.15 KOO32913.1 - 4.9e-12 45.5 0.1 1.4e-11 44.0 0.1 1.9 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region GTP_EFTU_D2 PF03144.25 KOO32913.1 - 7.6e-07 29.4 1.9 0.029 14.7 0.1 3.2 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOO32913.1 - 4.4e-06 26.8 0.0 1.1e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 KOO32913.1 - 0.0042 17.3 0.0 0.0087 16.3 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO32913.1 - 0.012 15.2 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 Ras family SRPRB PF09439.10 KOO32913.1 - 0.064 12.7 0.0 0.35 10.3 0.0 2.1 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU_D4 PF14578.6 KOO32913.1 - 0.082 12.8 0.6 0.4 10.6 0.1 2.4 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Mito_carr PF00153.27 KOO32914.1 - 9.7e-47 156.8 3.5 9.9e-16 57.5 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Laminin_G_3 PF13385.6 KOO32915.1 - 6.4e-06 26.4 0.4 6.4e-06 26.4 0.4 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Dimer_Tnp_hAT PF05699.14 KOO32916.1 - 8.2e-05 22.3 0.1 0.00017 21.3 0.1 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region NUDIX PF00293.28 KOO32917.1 - 7.3e-21 74.6 0.1 1.4e-20 73.6 0.1 1.5 1 0 0 1 1 1 1 NUDIX domain DUF4427 PF14468.6 KOO32919.1 - 0.2 11.7 0.2 0.35 10.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4427) HSP70 PF00012.20 KOO32920.1 - 0.0052 15.0 2.0 0.0056 14.9 2.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Sec1 PF00995.23 KOO32921.1 - 5.7e-86 290.0 0.0 5.8e-74 250.3 0.0 2.0 1 1 1 2 2 2 2 Sec1 family 23S_rRNA_IVP PF05635.11 KOO32921.1 - 0.088 13.1 0.7 0.15 12.4 0.7 1.3 1 0 0 1 1 1 0 23S rRNA-intervening sequence protein EF-hand_7 PF13499.6 KOO32922.1 - 9.6e-10 38.8 0.1 1.6e-09 38.1 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO32922.1 - 6.5e-06 25.7 0.0 0.00055 19.6 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO32922.1 - 8.8e-05 21.8 0.0 0.00017 20.9 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO32922.1 - 0.00049 19.4 0.1 0.0011 18.4 0.0 1.7 2 0 0 2 2 2 1 EF hand EF_assoc_1 PF08355.12 KOO32922.1 - 0.00076 19.0 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 EF hand associated EF-hand_8 PF13833.6 KOO32922.1 - 0.013 15.3 0.2 0.26 11.2 0.0 2.3 1 1 1 2 2 2 0 EF-hand domain pair EF_assoc_2 PF08356.12 KOO32922.1 - 0.08 13.0 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 EF hand associated ANT PF03374.14 KOO32923.1 - 0.054 13.8 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain Tub PF01167.18 KOO32925.1 - 6.1e-88 294.6 0.1 9.7e-88 294.0 0.1 1.3 1 0 0 1 1 1 1 Tub family OTU PF02338.19 KOO32925.1 - 1.8e-10 41.4 0.1 4.5e-10 40.1 0.1 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease Trypsin_2 PF13365.6 KOO32925.1 - 7.5e-05 23.7 0.2 0.00029 21.8 0.2 2.1 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_C65 PF10275.9 KOO32925.1 - 0.39 10.1 1.5 1.2 8.5 0.7 1.9 1 1 1 2 2 2 0 Peptidase C65 Otubain Succ_DH_flav_C PF02910.20 KOO32925.1 - 2.4 8.1 4.9 2.5 8.1 0.1 3.1 3 0 0 3 3 3 0 Fumarate reductase flavoprotein C-term Flagellin_N PF00669.20 KOO32926.1 - 0.0053 16.9 0.1 0.014 15.5 0.1 1.6 1 0 0 1 1 1 1 Bacterial flagellin N-terminal helical region DUF2457 PF10446.9 KOO32927.1 - 0.19 10.8 3.7 0.22 10.6 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) FAD_binding_4 PF01565.23 KOO32928.1 - 0.039 13.7 0.1 0.069 12.9 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Acetyltransf_1 PF00583.25 KOO32928.1 - 0.13 12.5 0.0 4.9 7.4 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family ADK PF00406.22 KOO32929.1 - 2.6e-30 105.5 0.0 2.6e-20 73.0 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 KOO32929.1 - 3.3e-15 56.7 0.0 1.2e-08 35.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KOO32929.1 - 0.0036 17.9 0.0 0.014 16.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain DUF5582 PF17819.1 KOO32929.1 - 0.011 16.2 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5582) Cytidylate_kin2 PF13189.6 KOO32929.1 - 0.063 13.4 0.0 3.7 7.6 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase-like family 2OG-FeII_Oxy_3 PF13640.6 KOO32930.1 - 5.5e-16 59.2 0.1 1.1e-15 58.3 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO32930.1 - 4.5e-05 23.9 11.1 4.5e-05 23.9 11.1 2.4 2 0 0 2 2 2 1 ShK domain-like Chorismate_bind PF00425.18 KOO32931.1 - 1.8e-82 276.8 0.0 2.5e-82 276.3 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Aminotran_4 PF01063.19 KOO32931.1 - 4.3e-18 66.0 0.0 7e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 Amino-transferase class IV TrbM PF07424.11 KOO32931.1 - 0.12 12.3 0.3 11 6.0 0.1 2.3 2 0 0 2 2 2 0 TrbM CLP_protease PF00574.23 KOO32932.1 - 1.7e-47 161.7 0.0 2.9e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 Clp protease Fer2 PF00111.27 KOO32933.1 - 5.2e-06 26.3 1.8 9.2e-06 25.5 1.8 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain EF-hand_6 PF13405.6 KOO32934.1 - 2.8e-08 33.1 0.1 0.00038 20.1 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO32934.1 - 2.8e-06 27.7 0.5 0.014 15.9 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO32934.1 - 7.9e-06 25.1 0.1 0.014 14.9 0.0 3.3 3 0 0 3 3 3 2 EF hand UTP15_C PF09384.10 KOO32934.1 - 0.0069 16.1 0.1 0.017 14.8 0.1 1.6 1 0 0 1 1 1 1 UTP15 C terminal EF-hand_5 PF13202.6 KOO32934.1 - 0.085 12.4 0.2 2.8 7.6 0.0 3.0 3 0 0 3 3 3 0 EF hand EF-hand_8 PF13833.6 KOO32934.1 - 0.16 11.9 0.1 0.82 9.6 0.1 2.4 1 1 0 1 1 1 0 EF-hand domain pair XPG_I_2 PF12813.7 KOO32934.1 - 0.69 9.3 6.1 0.062 12.8 0.8 1.8 2 0 0 2 2 2 0 XPG domain containing Ank_2 PF12796.7 KOO32935.1 - 8e-07 29.6 0.6 2.7e-06 27.9 0.5 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO32935.1 - 2.3e-06 28.0 0.4 0.0045 17.5 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO32935.1 - 5.2e-05 23.5 3.7 0.012 16.1 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO32935.1 - 0.00012 22.3 1.2 1.9 9.3 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat CDC45 PF02724.14 KOO32936.1 - 0.18 10.1 8.3 0.27 9.5 8.3 1.1 1 0 0 1 1 1 0 CDC45-like protein VIR_N PF15912.5 KOO32936.1 - 3.5 7.1 4.5 5.5 6.5 4.5 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal APG6_N PF17675.1 KOO32936.1 - 5.3 7.6 25.5 13 6.3 25.5 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Borrelia_P83 PF05262.11 KOO32936.1 - 9.6 4.6 18.8 14 4.0 18.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein WD40 PF00400.32 KOO32937.1 - 6.9e-19 67.8 14.4 0.0066 17.3 0.2 7.4 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO32937.1 - 0.0087 16.3 0.1 13 6.2 0.0 3.7 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOO32937.1 - 0.024 14.0 0.0 0.07 12.4 0.0 1.6 1 1 0 1 1 1 0 WD40-like domain Kelch_6 PF13964.6 KOO32937.1 - 0.041 14.2 0.2 7 7.1 0.0 3.4 3 0 0 3 3 3 0 Kelch motif LRR_4 PF12799.7 KOO32937.1 - 0.045 14.2 0.0 61 4.2 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOO32937.1 - 0.17 12.0 5.8 14 6.0 0.1 4.7 6 0 0 6 6 6 0 Leucine Rich repeat IQ PF00612.27 KOO32939.1 - 0.012 15.3 3.3 0.012 15.3 3.3 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif MSC PF09402.10 KOO32939.1 - 0.018 14.5 0.1 0.032 13.7 0.1 1.3 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain LRR_6 PF13516.6 KOO32940.1 - 2.7e-09 36.3 4.9 0.16 12.1 0.1 4.9 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.7 KOO32940.1 - 0.0011 19.3 0.0 0.072 13.5 0.2 2.9 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) DUF3197 PF11432.8 KOO32940.1 - 0.15 12.0 0.1 0.32 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3197) NYD-SP12_N PF15015.6 KOO32941.1 - 0.28 9.5 0.3 4.3 5.6 0.0 2.0 2 0 0 2 2 2 0 Spermatogenesis-associated, N-terminal Pkinase PF00069.25 KOO32942.1 - 3.1e-59 200.5 0.0 3.9e-59 200.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO32942.1 - 1.6e-45 155.4 0.0 2.1e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Chloroa_b-bind PF00504.21 KOO32942.1 - 9.1e-36 123.8 0.1 2.2e-35 122.6 0.1 1.6 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Kinase-like PF14531.6 KOO32942.1 - 1.4e-07 31.1 0.0 1.6e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOO32942.1 - 1.4e-05 25.1 0.4 0.015 15.3 0.1 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO32942.1 - 0.00015 20.7 0.0 0.00032 19.6 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KOO32942.1 - 0.021 14.2 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ntox46 PF15538.6 KOO32942.1 - 0.027 14.4 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial toxin 46 Herpes_capsid PF06112.11 KOO32942.1 - 0.031 14.3 5.7 0.054 13.6 5.7 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Haspin_kinase PF12330.8 KOO32942.1 - 0.081 11.8 0.1 0.39 9.6 0.1 1.9 1 1 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 KOO32942.1 - 0.12 11.9 0.1 0.25 10.9 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 KOO32942.1 - 0.17 10.9 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 COQ9 PF08511.11 KOO32943.1 - 9.4e-11 41.3 0.0 1.7e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 COQ9 Peptidase_M16_M PF16187.5 KOO32944.1 - 6e-48 163.5 0.0 2.1e-35 122.4 0.0 3.0 3 0 0 3 3 3 2 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 KOO32944.1 - 2.3e-25 89.7 0.0 6.1e-13 49.2 0.0 2.9 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOO32944.1 - 1.2e-13 51.3 0.0 4.1e-13 49.5 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Ribosomal_L13e PF01294.18 KOO32945.1 - 0.00046 20.1 10.0 1 9.2 0.2 4.4 2 1 3 5 5 5 3 Ribosomal protein L13e RPAP1_C PF08620.10 KOO32945.1 - 1.6 8.9 8.2 34 4.7 0.3 4.6 3 2 2 5 5 5 0 RPAP1-like, C-terminal RTX PF02382.15 KOO32945.1 - 5.9 6.5 6.5 9.3 5.8 6.5 1.2 1 0 0 1 1 1 0 N-terminal domain in RTX protein Peptidase_M17 PF00883.21 KOO32946.1 - 4.3e-101 338.3 0.2 6.9e-101 337.6 0.2 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 KOO32946.1 - 3.5e-20 72.1 1.6 5.8e-19 68.2 0.5 2.5 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain DUF4419 PF14388.6 KOO32946.1 - 1.3e-19 70.7 0.0 1.9e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) RrnaAD PF00398.20 KOO32948.1 - 9.6e-25 87.1 0.0 1.2e-24 86.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase TPR_MLP1_2 PF07926.12 KOO32949.1 - 1.7 8.7 4.1 4.8 7.3 0.8 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Ammonium_transp PF00909.21 KOO32950.1 - 2.4e-117 392.0 29.8 2.7e-117 391.8 29.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family p25-alpha PF05517.12 KOO32951.1 - 0.083 13.0 0.1 0.31 11.2 0.1 1.9 1 1 0 1 1 1 0 p25-alpha DEAD PF00270.29 KOO32954.1 - 2.2e-32 112.2 0.0 2.7e-19 69.6 0.0 3.2 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO32954.1 - 3.2e-29 101.5 0.0 9.9e-29 99.9 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain TAF4 PF05236.14 KOO32954.1 - 0.091 12.5 13.5 0.14 11.9 13.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CMS1 PF14617.6 KOO32954.1 - 0.88 8.9 0.0 0.88 8.9 0.0 3.3 2 1 1 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit TRAP_alpha PF03896.16 KOO32954.1 - 3.2 6.9 4.6 5.9 6.0 4.6 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RPN2_C PF18004.1 KOO32954.1 - 7.3 6.5 16.2 13 5.6 16.2 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain IHABP4_N PF16174.5 KOO32955.1 - 2.3 8.8 11.0 13 6.4 11.1 2.1 1 1 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Mito_carr PF00153.27 KOO32956.1 - 2.7e-58 193.9 0.7 1e-23 83.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOO32956.1 - 0.00016 20.9 0.4 0.21 10.7 0.0 2.4 2 1 0 2 2 2 2 Gammaproteobacterial serine protease PK PF00224.21 KOO32957.1 - 1e-113 379.8 1.0 1.3e-113 379.5 1.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KOO32957.1 - 2.3e-13 50.4 0.2 8.2e-13 48.6 0.0 2.0 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KOO32957.1 - 0.025 13.7 0.1 0.061 12.5 0.1 1.7 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family URO-D PF01208.17 KOO32958.1 - 4.8e-98 328.5 0.0 5.7e-98 328.3 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) IF2_N PF04760.15 KOO32958.1 - 0.052 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region E1-E2_ATPase PF00122.20 KOO32959.1 - 2.7e-34 118.3 1.8 2.7e-34 118.3 1.8 1.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 KOO32959.1 - 4.4e-06 26.7 0.0 1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KOO32959.1 - 2e-05 24.2 0.0 4.9e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Endosulfine PF04667.17 KOO32960.1 - 2.4e-08 34.0 0.1 2.9e-08 33.7 0.1 1.1 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region NDK PF00334.19 KOO32961.1 - 0.0046 17.0 0.0 0.01 15.9 0.0 1.6 2 0 0 2 2 2 1 Nucleoside diphosphate kinase Calreticulin PF00262.18 KOO32962.1 - 2.7e-146 487.1 3.1 3.2e-146 486.9 3.1 1.0 1 0 0 1 1 1 1 Calreticulin family TPR_14 PF13428.6 KOO32963.1 - 1e-08 35.2 24.4 0.0083 16.9 0.6 8.0 4 3 3 7 7 7 4 Tetratricopeptide repeat TPR_20 PF14561.6 KOO32963.1 - 4.6e-06 26.9 8.6 0.0069 16.7 0.3 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO32963.1 - 8.4e-06 25.9 7.3 0.049 13.9 0.0 4.5 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KOO32963.1 - 8.8e-06 26.2 22.5 0.00025 21.5 1.9 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO32963.1 - 1.1e-05 25.1 13.3 0.76 10.0 0.0 6.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO32963.1 - 0.00012 22.3 5.9 0.018 15.3 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO32963.1 - 0.0015 17.8 11.6 0.0097 15.1 1.5 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO32963.1 - 0.0019 18.7 3.5 7.7 7.4 0.4 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO32963.1 - 0.0036 17.2 3.4 4.1 7.7 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO32963.1 - 0.0052 16.4 2.8 2.1 8.1 0.1 4.4 4 0 0 4 4 4 1 TPR repeat TPR_8 PF13181.6 KOO32963.1 - 0.0059 16.7 3.1 6.2 7.3 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO32963.1 - 0.0072 16.9 0.6 0.0072 16.9 0.6 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO32963.1 - 0.072 13.5 2.9 0.61 10.6 0.3 3.8 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO32963.1 - 0.96 10.3 8.4 7.4 7.5 0.2 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO32963.1 - 1.1 9.2 6.7 27 4.8 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat DLH PF01738.18 KOO32964.1 - 1.4e-16 60.7 0.0 1.5e-16 60.6 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 KOO32964.1 - 4.6e-05 23.0 0.0 0.21 11.0 0.0 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 KOO32964.1 - 0.0014 18.5 0.0 0.0017 18.2 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF1100 PF06500.11 KOO32964.1 - 0.0037 16.1 0.0 0.0052 15.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_1 PF00561.20 KOO32964.1 - 0.014 15.1 0.0 0.3 10.7 0.0 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold BAAT_C PF08840.11 KOO32964.1 - 0.12 12.3 0.4 4.6 7.1 0.0 2.3 2 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Kinesin PF00225.23 KOO32965.1 - 1.3e-34 119.7 0.0 3.2e-33 115.1 0.0 2.5 2 1 0 2 2 2 1 Kinesin motor domain His_Phos_1 PF00300.22 KOO32965.1 - 1.4e-19 70.5 0.0 2.5e-18 66.5 0.0 2.8 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Microtub_bd PF16796.5 KOO32965.1 - 5.8e-09 36.0 0.0 1e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding AAA_22 PF13401.6 KOO32965.1 - 0.0069 16.7 0.1 0.057 13.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO32965.1 - 0.044 14.2 1.1 0.1 13.0 0.6 2.0 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 KOO32965.1 - 0.047 13.4 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein EMP70 PF02990.16 KOO32966.1 - 6.3e-164 546.5 5.6 8.4e-164 546.1 5.6 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 CorA PF01544.18 KOO32966.1 - 0.031 13.6 0.4 0.031 13.6 0.4 2.4 4 0 0 4 4 4 0 CorA-like Mg2+ transporter protein SMC_Nse1 PF07574.13 KOO32967.1 - 3e-05 24.0 0.0 0.00038 20.4 0.0 2.0 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex Asp_Arg_Hydrox PF05118.15 KOO32969.1 - 4.1e-38 130.7 0.0 5.9e-38 130.2 0.0 1.2 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Cupin_2 PF07883.11 KOO32969.1 - 0.065 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Replic_Relax PF13814.6 KOO32969.1 - 0.082 13.0 0.1 0.2 11.7 0.1 1.6 2 0 0 2 2 2 0 Replication-relaxation Chloroa_b-bind PF00504.21 KOO32970.1 - 2.2e-32 112.8 0.0 2.9e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Sel1 PF08238.12 KOO32971.1 - 2.3e-57 190.1 60.2 1.3e-06 28.9 0.6 10.1 11 0 0 11 11 11 9 Sel1 repeat Dehyd-heme_bind PF09098.10 KOO32971.1 - 0.02 14.5 5.9 0.44 10.1 0.1 3.6 1 1 1 3 3 3 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding Ribosomal_S13_N PF08069.12 KOO32971.1 - 1 9.5 17.0 1e+02 3.0 0.1 7.2 8 0 0 8 8 8 0 Ribosomal S13/S15 N-terminal domain RIC1 PF07064.13 KOO32971.1 - 3.2 7.1 12.5 7.8 5.8 0.6 5.5 4 3 3 8 8 8 0 RIC1 Arm PF00514.23 KOO32973.1 - 4.9e-31 105.8 30.7 2.8e-06 27.2 0.0 7.1 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KOO32973.1 - 1.4e-07 31.7 0.0 0.053 13.6 0.0 3.4 1 1 4 5 5 5 4 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.13 KOO32973.1 - 0.028 13.9 0.1 6.4 6.1 0.0 3.5 3 1 1 4 4 4 0 Armadillo-like Succ_CoA_lig PF13607.6 KOO32973.1 - 8.9 6.1 24.5 0.18 11.6 1.7 4.0 2 2 3 5 5 5 0 Succinyl-CoA ligase like flavodoxin domain Arm PF00514.23 KOO32974.1 - 1.5e-40 136.0 40.1 3.8e-06 26.7 0.0 9.1 9 0 0 9 9 9 9 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KOO32974.1 - 1e-10 41.9 0.0 0.097 12.7 0.0 4.8 1 1 4 5 5 5 4 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.13 KOO32974.1 - 0.0032 17.0 0.0 10 5.5 0.0 4.7 3 2 1 5 5 5 1 Armadillo-like Ish1 PF10281.9 KOO32975.1 - 0.07 13.5 0.0 0.71 10.2 0.0 2.4 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein HBS1_N PF08938.10 KOO32975.1 - 0.11 12.8 1.5 0.14 12.4 1.5 1.3 1 0 0 1 1 1 0 HBS1 N-terminus HisKA_3 PF07730.13 KOO32975.1 - 0.16 12.5 5.1 0.79 10.3 4.6 2.1 1 1 1 2 2 2 0 Histidine kinase Vir_act_alpha_C PF10400.9 KOO32975.1 - 0.66 10.7 5.7 36 5.1 5.7 2.2 1 1 0 1 1 1 0 Virulence activator alpha C-term WASH-7_C PF14746.6 KOO32976.1 - 1.6e-49 167.9 0.4 1.8e-49 167.8 0.4 1.0 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal Linocin_M18 PF04454.12 KOO32976.1 - 0.04 13.2 0.1 0.051 12.9 0.1 1.1 1 0 0 1 1 1 0 Encapsulating protein for peroxidase PolyA_pol_arg_C PF12626.7 KOO32976.1 - 0.044 13.8 1.1 0.058 13.4 1.1 1.1 1 0 0 1 1 1 0 Polymerase A arginine-rich C-terminus DUF1673 PF07895.11 KOO32976.1 - 0.14 11.9 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Mitofilin PF09731.9 KOO32977.1 - 1.9e-26 93.1 27.1 2.6e-26 92.6 27.1 1.2 1 0 0 1 1 1 1 Mitochondrial inner membrane protein zf-C4H2 PF10146.9 KOO32977.1 - 0.029 14.7 0.0 0.029 14.7 0.0 2.4 1 1 1 2 2 2 0 Zinc finger-containing protein Glyco_hydro_1 PF00232.18 KOO32978.1 - 6.1e-137 456.7 0.1 7.3e-137 456.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 ArfGap PF01412.18 KOO32979.1 - 1.7e-29 102.2 1.3 2.1e-29 102.0 1.3 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DnaJ_CXXCXGXG PF00684.19 KOO32979.1 - 0.1 13.0 2.8 0.26 11.7 2.6 1.7 1 1 1 2 2 2 0 DnaJ central domain zf-B_box PF00643.24 KOO32979.1 - 0.17 12.1 0.2 0.17 12.1 0.2 2.0 2 0 0 2 2 2 0 B-box zinc finger ACBP PF00887.19 KOO32980.1 - 4.9e-16 58.7 0.0 9.6e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein RVT_2 PF07727.14 KOO32983.1 - 1.7e-22 80.3 0.0 2.4e-21 76.5 0.0 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 KOO32983.1 - 0.0027 17.5 0.6 0.0068 16.2 0.1 1.8 2 0 0 2 2 2 1 GAG-pre-integrase domain LRR_6 PF13516.6 KOO32984.1 - 6.1e-22 75.8 11.8 4.3e-05 23.2 0.1 6.7 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.7 KOO32984.1 - 0.0013 19.0 1.3 47 4.6 0.0 5.0 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) CbiG_N PF11760.8 KOO32984.1 - 0.013 15.4 6.0 7.3 6.7 0.2 4.3 4 0 0 4 4 4 0 Cobalamin synthesis G N-terminal Arm-DNA-bind_1 PF09003.10 KOO32984.1 - 0.017 15.2 7.7 3.2 8.0 0.1 4.1 1 1 3 4 4 4 0 Bacteriophage lambda integrase, Arm DNA-binding domain HHH_5 PF14520.6 KOO32984.1 - 0.062 13.9 6.7 1.5 9.5 1.2 4.7 3 1 1 4 4 4 0 Helix-hairpin-helix domain HOASN PF14515.6 KOO32984.1 - 0.53 10.7 6.6 16 5.9 0.6 4.1 1 1 2 3 3 3 0 Haem-oxygenase-associated N-terminal helices Peptidase_C48 PF02902.19 KOO32985.1 - 7.5e-11 42.3 0.0 4.1e-10 39.9 0.0 1.9 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain ACC_epsilon PF13822.6 KOO32985.1 - 0.13 12.9 0.8 0.44 11.3 0.1 2.0 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit Gelsolin PF00626.22 KOO32986.1 - 1.2e-24 86.0 0.0 1e-07 31.7 0.0 3.3 3 0 0 3 3 3 3 Gelsolin repeat Tfb2_C PF18307.1 KOO32986.1 - 0.0037 17.7 0.0 0.014 15.8 0.0 2.0 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain DNA_pol_B_exo1 PF03104.19 KOO32988.1 - 6.2e-46 157.1 0.0 1e-45 156.4 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 KOO32988.1 - 5.3e-15 55.1 0.4 6.3e-12 44.9 0.5 3.7 2 1 0 2 2 2 1 DNA polymerase family B RNase_H_2 PF13482.6 KOO32988.1 - 3.2e-07 30.5 0.0 1.8e-06 28.0 0.0 2.1 2 0 0 2 2 2 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.9 KOO32988.1 - 8.6e-06 25.6 0.0 2.3e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB NAPRTase_C PF17956.1 KOO32988.1 - 0.12 12.8 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain WD40 PF00400.32 KOO32989.1 - 4.8e-24 84.2 0.8 1.6e-08 35.1 0.0 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat Prp19 PF08606.11 KOO32989.1 - 9.8e-15 54.3 1.2 2e-14 53.3 1.2 1.6 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 KOO32989.1 - 2.2e-07 31.1 0.0 0.0024 18.1 0.0 4.4 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO32989.1 - 0.015 14.3 0.9 1.6 7.6 0.0 3.0 1 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 KOO32989.1 - 0.09 12.5 0.0 4.4 7.0 0.0 2.5 2 0 0 2 2 2 0 TUP1-like enhancer of split DUF3987 PF13148.6 KOO32990.1 - 0.00042 19.4 0.2 0.91 8.5 0.1 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF3987) YqaJ PF09588.10 KOO32991.1 - 7.9e-18 65.0 0.0 1.1e-17 64.5 0.0 1.2 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain BAH PF01426.18 KOO32992.1 - 2.5e-08 33.8 0.0 3.6e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 BAH domain Laminin_G_3 PF13385.6 KOO32993.1 - 0.097 12.8 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Rdx PF10262.9 KOO32994.1 - 0.00012 22.2 0.0 0.00013 22.1 0.0 1.1 1 0 0 1 1 1 1 Rdx family zf-C3HC4_3 PF13920.6 KOO32995.1 - 5.2e-12 45.4 9.9 9.7e-12 44.6 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO32995.1 - 3.4e-05 23.6 9.3 7.6e-05 22.5 9.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOO32995.1 - 3.9e-05 23.9 12.1 7.9e-05 22.9 12.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO32995.1 - 0.0099 15.7 10.8 0.019 14.8 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO32995.1 - 0.015 15.3 9.8 0.037 14.0 9.8 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-P11 PF03854.14 KOO32995.1 - 0.089 12.5 5.7 0.23 11.2 5.7 1.6 1 0 0 1 1 1 0 P-11 zinc finger zf-C2H2 PF00096.26 KOO32997.1 - 3.3e-35 118.6 63.5 0.0001 22.5 1.4 8.4 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO32997.1 - 1.6e-32 110.4 59.7 3.9e-06 27.0 1.0 9.2 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO32997.1 - 3.6e-22 77.1 54.4 0.015 16.1 0.7 8.6 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOO32997.1 - 3e-05 23.9 47.6 0.11 12.5 0.4 8.2 8 0 0 8 8 8 6 C2H2-type zinc finger CHORD PF04968.12 KOO32997.1 - 0.033 14.9 44.1 2.6 8.8 0.8 7.4 1 1 6 7 7 7 0 CHORD zf-LYAR PF08790.11 KOO32997.1 - 0.13 12.2 17.3 16 5.5 0.1 7.2 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger zf-C2H2_aberr PF17017.5 KOO32997.1 - 0.45 10.6 25.3 0.28 11.3 1.1 6.1 2 1 3 6 6 6 0 Aberrant zinc-finger RuBisCo_chap_C PF18087.1 KOO32998.1 - 6.3e-05 22.7 0.0 9.5e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Rubisco Assembly chaperone C-terminal domain Radical_SAM PF04055.21 KOO32999.1 - 2e-09 38.1 0.0 2.4e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 KOO33000.1 - 1.3e-22 80.5 0.0 1.6e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_NdrI PF07972.11 KOO33000.1 - 0.018 15.2 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 NrdI Flavodoxin like Flavodoxin_5 PF12724.7 KOO33000.1 - 0.049 13.9 0.0 0.085 13.1 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin domain GerD PF17898.1 KOO33001.1 - 3.6e-06 26.9 12.3 0.00045 20.2 8.7 2.7 2 1 0 2 2 2 2 Spore germination GerD central core domain STI1 PF17830.1 KOO33001.1 - 7.9e-06 25.7 24.1 0.031 14.2 6.6 4.5 3 2 0 3 3 3 3 STI1 domain DUF2999 PF11212.8 KOO33001.1 - 0.02 15.2 0.2 0.02 15.2 0.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF2999) TetR_C_11 PF16859.5 KOO33001.1 - 0.038 14.3 2.2 0.35 11.2 0.3 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain FlgM PF04316.13 KOO33001.1 - 0.082 13.3 0.3 0.082 13.3 0.3 2.5 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM DUF3417 PF11897.8 KOO33001.1 - 0.091 13.2 4.7 17 5.9 0.2 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF3417) Dehydrin PF00257.19 KOO33001.1 - 0.13 12.8 1.3 0.16 12.5 0.5 1.6 2 0 0 2 2 2 0 Dehydrin Rotamase PF00639.21 KOO33001.1 - 0.97 10.4 4.3 1.4 9.9 0.2 2.5 2 1 0 2 2 2 0 PPIC-type PPIASE domain ABC_tran_CTD PF16326.5 KOO33001.1 - 9.1 6.6 17.8 7.7 6.8 0.8 4.7 3 2 2 5 5 5 0 ABC transporter C-terminal domain SET PF00856.28 KOO33002.1 - 3.7e-07 30.7 0.0 6.7e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 SET domain Elong-fact-P_C PF09285.11 KOO33005.1 - 1.2e-05 24.9 0.8 17 5.3 0.0 5.0 1 1 3 4 4 4 4 Elongation factor P, C-terminal SRRM_C PF15230.6 KOO33005.1 - 0.47 11.1 25.1 20 5.8 0.2 5.4 1 1 3 4 4 4 0 Serine/arginine repetitive matrix protein C-terminus Aldo_ket_red PF00248.21 KOO33006.1 - 1.8e-46 158.6 0.0 9.6e-25 87.4 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family adh_short_C2 PF13561.6 KOO33007.1 - 0.0002 21.0 0.1 0.00025 20.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF3349 PF11829.8 KOO33008.1 - 0.2 12.5 0.9 5.6 7.8 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) F420_oxidored PF03807.17 KOO33009.1 - 4.4e-07 30.4 0.0 1.9e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Allexi_40kDa PF05549.11 KOO33009.1 - 0.08 12.4 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein AbiEi_3_N PF17194.4 KOO33009.1 - 0.096 12.7 0.1 0.28 11.2 0.1 1.8 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain TRAM_LAG1_CLN8 PF03798.16 KOO33010.1 - 9.6e-16 58.1 10.6 1.3e-15 57.7 10.6 1.1 1 0 0 1 1 1 1 TLC domain LRR_6 PF13516.6 KOO33011.1 - 1.7e-27 93.1 14.7 4.5e-05 23.2 0.0 9.8 10 0 0 10 10 10 7 Leucine Rich repeat LRR_4 PF12799.7 KOO33011.1 - 2.8e-07 30.7 8.1 0.29 11.6 0.1 6.5 4 3 3 7 7 7 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO33011.1 - 1.5e-05 24.9 0.9 11 7.0 0.0 6.8 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO33011.1 - 0.013 15.3 11.5 30 4.5 0.1 7.4 6 2 1 7 7 7 0 Leucine rich repeat 60KD_IMP PF02096.20 KOO33013.1 - 2.9e-37 128.1 0.0 3.6e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein SfLAP PF11139.8 KOO33013.1 - 0.0029 17.1 0.1 0.0063 16.0 0.1 1.6 1 0 0 1 1 1 1 Sap, sulfolipid-1-addressing protein UBA_6 PF18039.1 KOO33014.1 - 0.014 15.3 10.1 8.4 6.4 0.6 4.6 4 0 0 4 4 4 0 UBA-like domain FtsK_alpha PF17854.1 KOO33014.1 - 1.5 9.0 4.1 5.5 7.2 0.1 4.0 2 2 1 3 3 3 0 FtsK alpha domain TRAM_LAG1_CLN8 PF03798.16 KOO33015.1 - 8.7e-09 35.4 8.6 1.1e-08 35.0 8.5 1.4 1 1 0 1 1 1 1 TLC domain TPR_2 PF07719.17 KOO33016.1 - 2.2e-08 33.6 26.2 5.1e-06 26.2 0.6 7.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33016.1 - 1.4e-07 31.1 21.8 7.3e-05 22.4 0.3 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO33016.1 - 2.6e-05 23.8 6.1 0.004 16.8 0.2 4.3 4 0 0 4 4 4 1 TPR repeat SHNi-TPR PF10516.9 KOO33016.1 - 8.1e-05 22.0 0.4 0.03 13.8 0.0 3.1 2 0 0 2 2 2 1 SHNi-TPR TPR_8 PF13181.6 KOO33016.1 - 0.00095 19.2 9.1 0.035 14.3 0.1 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat CS PF04969.16 KOO33016.1 - 0.0035 18.3 0.0 0.0062 17.5 0.0 1.4 1 0 0 1 1 1 1 CS domain TPR_9 PF13371.6 KOO33016.1 - 0.07 13.3 22.6 0.22 11.7 1.4 5.8 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO33016.1 - 0.22 11.8 24.5 0.13 12.6 1.2 6.5 7 2 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO33016.1 - 0.79 9.9 10.9 1.1 9.5 0.6 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat BTAD PF03704.17 KOO33016.1 - 3.1 8.2 49.9 0.1 13.0 2.0 6.7 4 2 2 6 6 6 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 KOO33016.1 - 3.3 8.5 7.6 25 5.8 0.7 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.32 KOO33018.1 - 1.9e-27 94.9 10.3 0.0022 18.8 0.2 9.9 10 0 0 10 10 10 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO33018.1 - 1.7e-05 25.1 0.0 0.29 11.5 0.0 4.7 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_5 PF13202.6 KOO33018.1 - 0.00056 19.3 0.2 0.015 14.8 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 KOO33018.1 - 0.0021 17.5 0.5 0.014 14.9 0.0 2.6 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 KOO33018.1 - 0.02 14.8 0.2 0.27 11.3 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.6 KOO33018.1 - 0.19 12.2 0.0 0.58 10.7 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair Beta_helix PF13229.6 KOO33019.1 - 0.0021 18.0 1.6 0.0021 18.0 1.6 3.3 1 1 2 3 3 3 1 Right handed beta helix region PAN_4 PF14295.6 KOO33019.1 - 0.16 11.9 0.0 0.44 10.5 0.0 1.6 1 0 0 1 1 1 0 PAN domain TBCC PF07986.12 KOO33020.1 - 3e-23 81.8 2.1 3.8e-23 81.5 2.1 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 KOO33020.1 - 0.031 13.9 9.4 0.11 12.1 9.4 1.7 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal ATP-synt_ab PF00006.25 KOO33021.1 - 9.2e-61 205.2 0.0 1.4e-60 204.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KOO33021.1 - 2.1e-22 79.4 3.5 4.1e-22 78.5 3.5 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 KOO33021.1 - 0.0061 15.9 0.2 0.0087 15.4 0.2 1.3 1 0 0 1 1 1 1 KaiC RecA PF00154.21 KOO33021.1 - 0.039 13.4 0.2 0.084 12.3 0.2 1.5 1 0 0 1 1 1 0 recA bacterial DNA recombination protein AAA_16 PF13191.6 KOO33021.1 - 0.05 14.0 0.4 0.24 11.8 0.3 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 KOO33021.1 - 0.052 13.9 0.2 0.11 12.8 0.2 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KOO33021.1 - 0.056 12.6 0.2 0.083 12.1 0.2 1.2 1 0 0 1 1 1 0 NB-ARC domain TrwB_AAD_bind PF10412.9 KOO33021.1 - 0.19 10.6 0.1 0.29 10.0 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF2075 PF09848.9 KOO33021.1 - 0.2 10.9 0.1 0.35 10.1 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PGA_cap PF09587.10 KOO33022.1 - 3.1e-35 121.8 0.0 5e-35 121.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap 2OG-FeII_Oxy_3 PF13640.6 KOO33026.1 - 1.2e-14 54.9 0.1 6.2e-14 52.7 0.1 2.2 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO33026.1 - 0.00038 20.9 0.0 0.001 19.5 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Galactosyl_T PF01762.21 KOO33026.1 - 0.023 14.5 0.0 0.056 13.3 0.0 1.6 2 0 0 2 2 2 0 Galactosyltransferase Chloroa_b-bind PF00504.21 KOO33027.1 - 9.5e-37 127.0 0.1 1.2e-36 126.6 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Phage_holin_2_1 PF04971.12 KOO33028.1 - 0.052 13.6 0.4 0.089 12.8 0.4 1.3 1 0 0 1 1 1 0 Bacteriophage P21 holin S Mg_trans_NIPA PF05653.14 KOO33029.1 - 4e-14 52.4 14.2 6.4e-14 51.7 14.2 1.3 1 0 0 1 1 1 1 Magnesium transporter NIPA SepZ PF06066.11 KOO33029.1 - 3.1 8.1 9.4 4.6 7.5 0.7 3.3 3 0 0 3 3 3 0 SepZ Cullin PF00888.22 KOO33030.1 - 2.9e-220 733.1 6.7 3.9e-220 732.6 6.7 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KOO33030.1 - 2.1e-27 95.0 1.2 2.1e-27 95.0 1.2 2.0 2 0 0 2 2 2 1 Cullin protein neddylation domain HTH_IclR PF09339.10 KOO33030.1 - 0.04 13.7 0.0 0.26 11.1 0.0 2.5 2 0 0 2 2 2 0 IclR helix-turn-helix domain Penicillinase_R PF03965.16 KOO33030.1 - 0.098 13.0 1.5 0.6 10.5 0.1 3.2 3 0 0 3 3 3 0 Penicillinase repressor DNA_repr_REX1B PF14966.6 KOO33030.1 - 0.11 13.2 1.5 26 5.6 0.0 3.6 3 0 0 3 3 3 0 DNA repair REX1-B Trehalase PF01204.18 KOO33031.1 - 9.7e-11 41.2 2.3 2.4e-08 33.3 0.9 2.2 2 0 0 2 2 2 2 Trehalase Glyco_hydro_63 PF03200.16 KOO33031.1 - 1.3e-10 40.7 0.0 1.6e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain TIMELESS PF04821.14 KOO33031.1 - 0.0066 15.8 0.0 0.07 12.4 0.0 2.0 2 0 0 2 2 2 1 Timeless protein NCA2 PF08637.10 KOO33033.1 - 1.2e-11 44.4 0.0 7.1e-11 41.8 0.0 1.9 1 1 1 2 2 2 2 ATP synthase regulation protein NCA2 Form_Nir_trans PF01226.17 KOO33034.1 - 2.1e-64 217.1 21.3 2.5e-64 216.9 21.3 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter DEAD PF00270.29 KOO33035.1 - 3.2e-21 75.9 0.0 5.5e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Sec63 PF02889.16 KOO33035.1 - 3e-20 72.5 0.0 4e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.31 KOO33035.1 - 1.5e-07 31.7 0.0 5.8e-07 29.8 0.0 2.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO33035.1 - 3.4e-07 30.4 0.0 6.2e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HHH_5 PF14520.6 KOO33035.1 - 0.00099 19.7 0.1 0.0024 18.4 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain T2SSE PF00437.20 KOO33035.1 - 0.0055 15.8 0.0 0.014 14.5 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein UvrD-helicase PF00580.21 KOO33035.1 - 0.0067 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 KOO33035.1 - 0.02 15.2 0.0 0.074 13.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO33035.1 - 0.021 15.2 0.0 0.021 15.2 0.0 2.8 3 1 0 3 3 3 0 AAA ATPase domain AAA_19 PF13245.6 KOO33035.1 - 0.027 14.8 0.0 0.13 12.6 0.0 2.2 1 1 0 1 1 1 0 AAA domain DUF1858 PF08984.11 KOO33035.1 - 0.032 14.4 0.0 0.081 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1858) zf-UBR PF02207.20 KOO33036.1 - 1.5e-20 73.1 12.0 3.2e-20 72.1 12.0 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DUF779 PF05610.11 KOO33036.1 - 0.16 12.2 0.6 0.35 11.1 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF779) PNRC PF15365.6 KOO33039.1 - 0.25 11.2 2.6 0.46 10.4 2.6 1.5 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator motif AAA_9 PF12781.7 KOO33040.1 - 2e-18 66.3 0.4 4.7e-18 65.1 0.3 1.6 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_6 PF12774.7 KOO33041.1 - 9.4e-118 392.9 0.0 2e-109 365.6 0.0 2.0 1 1 1 2 2 2 2 Hydrolytic ATP binding site of dynein motor region AAA_9 PF12781.7 KOO33041.1 - 3.6e-12 45.9 0.0 5.3e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_5 PF07728.14 KOO33041.1 - 0.091 12.8 0.0 2.2 8.3 0.0 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 KOO33042.1 - 1.5e-28 99.3 0.0 2e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain ART PF01129.18 KOO33043.1 - 0.0092 15.3 0.0 0.047 13.0 0.0 1.8 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase Cation_ATPase_N PF00690.26 KOO33044.1 - 0.00024 20.7 0.0 0.00053 19.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus DUF3182 PF11379.8 KOO33044.1 - 0.11 11.5 0.2 0.18 10.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) KH_1 PF00013.29 KOO33046.1 - 5.4e-20 71.0 3.1 1.1e-09 38.0 0.4 2.7 2 0 0 2 2 2 2 KH domain NYD-SP28 PF14772.6 KOO33046.1 - 2.9e-19 69.0 17.7 2.9e-19 69.0 17.7 5.4 2 1 2 4 4 4 1 Sperm tail Agenet PF05641.12 KOO33046.1 - 1.2e-09 38.5 4.0 0.001 19.5 0.0 3.1 3 0 0 3 3 3 2 Agenet domain NYD-SP28_assoc PF14775.6 KOO33046.1 - 4e-09 36.4 0.1 4e-09 36.4 0.1 3.3 3 0 0 3 3 3 1 Sperm tail C-terminal domain KH_2 PF07650.17 KOO33046.1 - 6.5e-05 22.7 2.3 0.22 11.4 0.4 3.5 1 1 2 3 3 3 2 KH domain KH_4 PF13083.6 KOO33046.1 - 0.00014 21.6 0.4 0.27 11.1 0.1 3.0 2 0 0 2 2 2 2 KH domain VCBS PF13517.6 KOO33048.1 - 3.4e-148 482.4 209.0 3.1e-13 50.1 5.2 18.3 6 4 13 19 19 19 18 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO33048.1 - 9.4e-94 307.0 227.1 3.9e-05 23.7 2.7 22.8 22 0 0 22 22 22 22 FG-GAP repeat Ephrin_rec_like PF07699.13 KOO33048.1 - 4.1e-25 87.3 131.1 1.7e-06 27.7 0.8 15.5 9 2 5 16 16 16 10 Putative ephrin-receptor like Dockerin_1 PF00404.18 KOO33048.1 - 6.3e-08 32.7 72.2 11 6.3 0.1 21.2 22 0 0 22 22 22 3 Dockerin type I domain zf-HYPF PF07503.12 KOO33048.1 - 2 8.2 24.4 4 7.3 0.3 5.4 5 0 0 5 5 5 0 HypF finger EF-hand_7 PF13499.6 KOO33049.1 - 1e-18 67.5 3.4 2e-10 41.0 0.0 3.5 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO33049.1 - 1.5e-18 65.0 4.2 0.00036 20.2 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO33049.1 - 9e-16 56.2 6.6 0.00032 20.0 0.1 4.7 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 KOO33049.1 - 3.7e-11 42.0 10.1 0.0072 15.8 0.9 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO33049.1 - 4.2e-09 36.1 4.5 3.6e-07 29.9 0.1 4.0 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_10 PF14788.6 KOO33049.1 - 0.12 12.3 0.4 46 4.0 0.0 3.2 3 0 0 3 3 3 0 EF hand Ion_trans PF00520.31 KOO33052.1 - 1e-132 440.8 43.4 4.9e-50 170.1 1.6 5.1 4 1 1 5 5 5 5 Ion transport protein PKD_channel PF08016.12 KOO33052.1 - 1.4e-09 37.2 34.5 0.00064 18.5 6.2 4.3 3 1 0 3 3 3 3 Polycystin cation channel GPHH PF16905.5 KOO33052.1 - 7.4e-07 28.8 0.0 1.7e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated NESP55 PF06390.12 KOO33053.1 - 0.31 10.6 0.9 0.42 10.2 0.9 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) NDK PF00334.19 KOO33055.1 - 1.3e-24 86.7 0.0 2e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DUF563 PF04577.14 KOO33055.1 - 0.00044 20.4 0.1 0.00069 19.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DUF5327 PF17261.2 KOO33056.1 - 0.018 15.8 0.2 0.033 14.9 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5327) Dimer_Tnp_hAT PF05699.14 KOO33057.1 - 0.00026 20.7 0.5 0.00061 19.5 0.2 1.8 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region V-SNARE_C PF12352.8 KOO33058.1 - 9.8e-08 32.2 6.2 1.4e-07 31.7 6.2 1.2 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus MARVEL PF01284.23 KOO33058.1 - 0.0013 18.8 4.6 0.19 11.8 0.9 3.0 3 0 0 3 3 3 1 Membrane-associating domain HTH_Bact PF18768.1 KOO33058.1 - 0.005 16.4 0.1 0.0083 15.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix bacterial domain Na_sulph_symp PF00939.19 KOO33058.1 - 0.0094 15.0 0.0 0.0098 15.0 0.0 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region DUF2721 PF11026.8 KOO33058.1 - 0.01 15.7 0.0 0.01 15.7 0.0 2.8 3 1 1 4 4 3 0 Protein of unknown function (DUF2721) PalH PF08733.10 KOO33058.1 - 0.019 14.0 0.0 0.36 9.8 0.0 2.0 2 0 0 2 2 2 0 PalH/RIM21 Cyt_bd_oxida_II PF02322.15 KOO33058.1 - 0.032 13.6 2.7 0.049 13.0 2.8 1.3 1 1 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II Sec20 PF03908.13 KOO33058.1 - 0.056 13.4 0.4 0.12 12.3 0.1 1.8 2 0 0 2 2 2 0 Sec20 DUF202 PF02656.15 KOO33058.1 - 0.11 13.0 3.6 0.5 10.8 0.4 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF202) GPDPase_memb PF10110.9 KOO33058.1 - 0.12 11.2 1.4 0.34 9.7 0.0 2.0 2 0 0 2 2 2 0 Membrane domain of glycerophosphoryl diester phosphodiesterase DUF2207 PF09972.9 KOO33058.1 - 0.18 10.5 2.3 0.49 9.1 2.3 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) FixQ PF05545.11 KOO33058.1 - 0.71 9.9 12.2 3.7 7.6 2.3 3.9 4 0 0 4 4 4 0 Cbb3-type cytochrome oxidase component FixQ DUF2976 PF11190.8 KOO33058.1 - 3.9 7.3 7.9 0.3 10.9 0.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) Synaptobrevin PF00957.21 KOO33058.1 - 4.6 7.1 6.1 0.22 11.3 0.2 2.0 2 0 0 2 2 1 0 Synaptobrevin DUF4131 PF13567.6 KOO33058.1 - 5.3 6.7 13.7 2.8 7.6 4.4 3.2 1 1 3 4 4 4 0 Domain of unknown function (DUF4131) NT-C2 PF10358.9 KOO33059.1 - 2.3e-05 24.1 0.0 4.9e-05 23.1 0.0 1.5 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins COG5 PF10392.9 KOO33059.1 - 0.031 14.4 2.7 0.031 14.4 2.7 2.1 2 1 0 2 2 2 0 Golgi transport complex subunit 5 DUF4472 PF14739.6 KOO33059.1 - 2.8 8.7 8.2 21 5.9 4.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) Cupin_3 PF05899.12 KOO33060.1 - 1.4e-07 31.1 0.1 4e-07 29.6 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF861) DZR PF12773.7 KOO33060.1 - 0.084 12.9 2.9 0.15 12.1 2.9 1.4 1 0 0 1 1 1 0 Double zinc ribbon TrmO PF01980.16 KOO33061.1 - 1.4e-20 73.7 0.2 2.9e-10 40.4 0.1 2.3 1 1 1 2 2 2 2 tRNA-methyltransferase O TrmO_C PF18389.1 KOO33061.1 - 3e-07 30.4 0.0 5e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 TrmO C-terminal domain PgpA PF04608.13 KOO33062.1 - 0.013 15.5 0.2 0.017 15.1 0.2 1.2 1 0 0 1 1 1 0 Phosphatidylglycerophosphatase A Ion_trans PF00520.31 KOO33063.1 - 3.9e-28 98.3 13.6 5.5e-28 97.8 13.6 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 KOO33063.1 - 3.5e-15 55.8 0.1 2e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KOO33063.1 - 4.1e-11 42.7 4.4 4.1e-11 42.7 4.4 2.3 2 1 0 2 2 2 1 Ion channel AC_N PF16214.5 KOO33063.1 - 0.11 11.5 0.1 0.22 10.6 0.1 1.3 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region ShK PF01549.24 KOO33065.1 - 1.5e-13 51.0 22.7 2.6e-09 37.5 7.3 3.3 3 0 0 3 3 3 2 ShK domain-like LRR_8 PF13855.6 KOO33066.1 - 1.4e-21 76.0 24.3 1.3e-07 31.2 1.5 5.2 3 1 1 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KOO33066.1 - 2.4e-19 69.1 16.3 0.00052 20.4 0.1 6.2 4 1 2 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO33066.1 - 6.7e-09 35.1 16.0 2.3 9.1 0.0 8.6 8 2 0 8 8 8 4 Leucine Rich Repeat LRR_6 PF13516.6 KOO33066.1 - 4.6 7.5 22.2 8.6 6.7 0.4 7.1 8 0 0 8 8 8 0 Leucine Rich repeat EF-hand_1 PF00036.32 KOO33067.1 - 6.1e-32 106.8 13.7 2e-07 30.0 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO33067.1 - 1.4e-28 99.1 3.5 4.1e-14 52.8 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO33067.1 - 6.3e-24 81.8 7.7 1.9e-06 27.3 0.0 4.4 3 1 1 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO33067.1 - 2.7e-23 81.5 7.9 3.5e-10 39.6 0.2 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO33067.1 - 1.1e-20 72.1 11.6 8.3e-06 25.1 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KOO33067.1 - 4.2e-10 39.8 0.3 2.9e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 KOO33067.1 - 1.2e-05 25.3 0.1 0.13 12.3 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.7 KOO33067.1 - 2.4e-05 24.2 2.2 0.012 15.5 0.1 2.7 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO33067.1 - 2.9e-05 24.4 0.0 0.19 12.0 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 KOO33067.1 - 9.1e-05 22.4 1.4 0.43 10.5 0.0 2.7 2 1 0 2 2 2 2 Tellurite resistance protein TerB p25-alpha PF05517.12 KOO33067.1 - 0.037 14.2 0.1 0.75 10.0 0.0 2.5 1 1 1 2 2 2 0 p25-alpha Dockerin_1 PF00404.18 KOO33067.1 - 0.11 12.7 3.0 2.9 8.2 0.8 2.8 2 1 1 3 3 3 0 Dockerin type I domain MotA_activ PF09114.10 KOO33067.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Transcription factor MotA, activation domain EFhand_Ca_insen PF08726.10 KOO33067.1 - 0.15 12.2 0.4 0.64 10.1 0.1 2.3 3 1 0 3 3 3 0 Ca2+ insensitive EF hand DUF533 PF04391.12 KOO33067.1 - 3.3 7.2 6.9 6 6.4 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF533) EF-hand_5 PF13202.6 KOO33068.1 - 5.1e-132 424.1 146.0 6.5e-06 25.4 1.2 28.1 14 14 14 28 28 28 28 EF hand EF-hand_1 PF00036.32 KOO33068.1 - 1.6e-117 374.6 141.2 2e-05 23.8 0.5 28.0 10 10 18 28 28 28 28 EF hand EF-hand_6 PF13405.6 KOO33068.1 - 1.5e-110 351.9 136.3 7.5e-05 22.4 0.4 28.0 10 10 18 28 28 28 28 EF-hand domain EF-hand_7 PF13499.6 KOO33068.1 - 1e-86 285.4 91.8 5.4e-09 36.4 3.5 20.0 5 5 9 14 14 14 14 EF-hand domain pair EF-hand_8 PF13833.6 KOO33068.1 - 5.1e-50 167.2 131.9 0.0059 16.4 0.2 27.6 13 12 15 28 28 28 23 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO33068.1 - 1e-08 35.5 40.6 7.4 6.9 0.1 18.5 1 1 12 14 14 14 1 Secreted protein acidic and rich in cysteine Ca binding region SHOCT PF09851.9 KOO33068.1 - 2.9e-08 33.2 27.6 3.7 7.4 0.0 14.9 19 0 0 19 19 19 3 Short C-terminal domain EF-hand_4 PF12763.7 KOO33068.1 - 2e-06 27.7 41.6 0.15 12.0 0.2 12.9 2 2 12 16 16 16 3 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO33068.1 - 3.7e-05 23.8 57.6 0.5 10.6 0.0 19.1 14 7 5 19 19 19 2 Dockerin type I domain PMBR PF09373.10 KOO33068.1 - 0.00052 20.1 6.4 1.7e+02 2.6 0.0 9.9 15 0 0 15 15 15 0 Pseudomurein-binding repeat DUF2782 PF11191.8 KOO33068.1 - 0.00073 19.7 0.0 8.2 6.7 0.0 5.9 4 2 0 5 5 5 1 Protein of unknown function (DUF2782) EFhand_Ca_insen PF08726.10 KOO33068.1 - 0.0017 18.4 0.9 18 5.5 0.0 5.3 5 0 0 5 5 5 0 Ca2+ insensitive EF hand Caleosin PF05042.13 KOO33068.1 - 0.041 13.8 40.0 3.1 7.7 0.3 10.4 4 3 3 8 8 8 0 Caleosin related protein CCD48 PF15799.5 KOO33068.1 - 0.11 10.7 0.6 16 3.7 0.1 4.4 5 2 2 7 7 7 0 Coiled-coil domain-containing protein 48 SPRY PF00622.28 KOO33069.1 - 0.018 15.2 0.0 0.039 14.1 0.0 1.6 1 1 0 1 1 1 0 SPRY domain TPT PF03151.16 KOO33070.1 - 2.1e-07 30.6 14.2 2.6e-07 30.3 14.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO33070.1 - 0.12 12.6 24.7 0.3 11.3 7.8 2.7 1 1 2 3 3 3 0 EamA-like transporter family Dimer_Tnp_hAT PF05699.14 KOO33072.1 - 1.9e-05 24.4 0.1 2.4e-05 24.0 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region N_BRCA1_IG PF16158.5 KOO33073.1 - 2.4e-28 98.8 0.4 5.4e-28 97.7 0.1 1.7 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene UBA PF00627.31 KOO33073.1 - 0.15 12.0 0.7 20 5.2 0.2 2.7 2 1 0 2 2 2 0 UBA/TS-N domain Nucleotid_trans PF03407.16 KOO33074.1 - 3.6e-09 36.9 0.0 6.1e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase NACHT PF05729.12 KOO33075.1 - 2.3e-05 24.4 0.0 6.6e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 KOO33075.1 - 0.0032 17.8 0.0 0.013 15.9 0.1 1.8 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 KOO33075.1 - 0.021 14.3 0.0 0.065 12.8 0.0 1.7 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA PF00004.29 KOO33075.1 - 0.076 13.4 0.0 0.26 11.7 0.0 1.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Amidohydro_1 PF01979.20 KOO33076.1 - 1.4e-21 77.3 0.0 1.1e-12 48.0 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family LRR_4 PF12799.7 KOO33076.1 - 3.7e-14 52.6 35.7 0.038 14.4 0.6 9.7 6 2 1 8 8 8 6 Leucine Rich repeats (2 copies) Amidohydro_3 PF07969.11 KOO33076.1 - 9.7e-12 45.1 0.1 1.8e-07 31.0 0.0 2.5 2 0 0 2 2 2 2 Amidohydrolase family Roc PF08477.13 KOO33076.1 - 1.6e-10 41.2 0.0 4.2e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 KOO33076.1 - 1.3e-08 34.5 33.7 0.00015 21.4 1.1 9.2 5 3 4 9 9 9 4 Leucine rich repeat Arf PF00025.21 KOO33076.1 - 0.00016 21.1 0.0 0.00036 20.0 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family LRR_6 PF13516.6 KOO33076.1 - 0.00017 21.3 48.6 0.0017 18.3 0.1 12.8 15 0 0 15 15 15 2 Leucine Rich repeat Ras PF00071.22 KOO33076.1 - 0.0009 18.9 0.0 0.0022 17.6 0.0 1.7 1 0 0 1 1 1 1 Ras family LRR_1 PF00560.33 KOO33076.1 - 0.029 14.9 20.2 16 6.5 0.0 10.4 13 0 0 13 13 12 0 Leucine Rich Repeat GTP_EFTU PF00009.27 KOO33076.1 - 0.037 13.5 0.0 0.26 10.8 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOO33076.1 - 0.05 13.7 0.0 0.27 11.3 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase LRR_6 PF13516.6 KOO33077.1 - 2.6e-12 45.7 31.5 0.0038 17.2 0.1 11.1 12 0 0 12 12 12 5 Leucine Rich repeat LRR_1 PF00560.33 KOO33077.1 - 1.5e-07 31.0 0.0 9.5 7.2 0.0 7.2 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO33077.1 - 1.9e-05 24.3 1.0 17 5.2 0.1 6.0 5 1 0 5 5 5 2 Leucine rich repeat LRR_4 PF12799.7 KOO33077.1 - 9.2e-05 22.7 2.1 26 5.4 0.0 6.4 5 1 0 6 6 6 0 Leucine Rich repeats (2 copies) Metal_CEHH PF14455.6 KOO33077.1 - 0.0004 20.1 0.0 0.004 16.8 0.0 2.2 1 1 1 2 2 2 1 Predicted metal binding domain TA_inhibitor PF17574.2 KOO33077.1 - 0.1 12.6 0.7 33 4.6 0.0 3.6 3 0 0 3 3 3 0 Inhibitor of toxin/antitoxin system (Gp4.5) Skp1 PF01466.19 KOO33077.1 - 0.3 11.2 5.3 0.6 10.3 0.0 2.5 2 0 0 2 2 2 0 Skp1 family, dimerisation domain Methyltransf_24 PF13578.6 KOO33078.1 - 4e-09 37.4 0.2 1.4e-07 32.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO33078.1 - 2.7e-07 31.2 0.0 4.6e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO33078.1 - 1.5e-05 24.8 0.0 2e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO33078.1 - 4e-05 24.2 0.0 7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 KOO33078.1 - 0.0001 22.1 0.0 0.00014 21.6 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_12 PF08242.12 KOO33078.1 - 0.00021 22.0 0.0 0.00042 21.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FerA PF08165.11 KOO33079.1 - 0.079 12.9 0.1 0.23 11.4 0.1 1.7 1 0 0 1 1 1 0 FerA (NUC095) domain DUF743 PF05332.11 KOO33079.1 - 0.15 12.1 0.7 0.59 10.2 0.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF743) Phage_int_SAM_1 PF02899.17 KOO33083.1 - 2.4 8.5 4.5 0.99 9.7 0.4 2.5 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain Presenilin PF01080.17 KOO33088.1 - 0.3 9.8 4.7 0.36 9.6 4.7 1.2 1 0 0 1 1 1 0 Presenilin Asp-B-Hydro_N PF05279.11 KOO33088.1 - 2.9 7.9 13.8 5 7.1 13.8 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Herpes_UL25 PF01499.16 KOO33089.1 - 8.2 4.8 9.4 12 4.3 9.4 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family WD40 PF00400.32 KOO33091.1 - 6.2e-41 137.6 8.1 4.5e-10 40.0 0.1 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO33091.1 - 6.6e-14 51.6 2.4 0.003 16.6 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO33091.1 - 8.5e-12 44.7 0.1 0.041 13.8 0.0 4.3 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 KOO33091.1 - 6.4e-11 42.4 0.4 0.029 14.7 0.0 3.9 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KOO33091.1 - 1.1e-07 30.6 0.0 0.002 16.6 0.0 3.3 1 1 2 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KOO33091.1 - 4.5e-06 26.7 0.1 0.00045 20.1 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 KOO33091.1 - 1e-05 25.0 1.4 0.69 9.2 0.0 3.7 1 1 3 4 4 4 3 Neuroblastoma-amplified sequence, N terminal DCX PF03607.17 KOO33091.1 - 0.00044 20.3 0.0 2.3 8.4 0.0 3.8 4 0 0 4 4 4 1 Doublecortin BBS2_Mid PF14783.6 KOO33091.1 - 0.0015 18.6 0.3 3.3 7.8 0.0 3.7 2 2 2 4 4 4 1 Ciliary BBSome complex subunit 2, middle region rOmpB PF12334.8 KOO33091.1 - 0.0021 17.6 2.3 2.9 7.3 0.1 3.7 1 1 2 4 4 4 1 Rickettsia outer membrane protein B WD40_like PF17005.5 KOO33091.1 - 0.0029 17.0 0.3 0.04 13.3 0.2 2.5 1 1 1 2 2 2 2 WD40-like domain IKI3 PF04762.12 KOO33091.1 - 0.015 13.3 0.1 1.4 6.8 0.1 2.8 1 1 0 1 1 1 0 IKI3 family CIDE-N PF02017.15 KOO33091.1 - 0.021 14.8 0.0 21 5.2 0.0 3.7 2 1 2 4 4 4 0 CIDE-N domain Dfp1_Him1_M PF08630.10 KOO33091.1 - 0.043 14.0 0.1 15 5.8 0.0 2.8 3 0 0 3 3 3 0 Dfp1/Him1, central region Peptidase_S9_N PF02897.15 KOO33091.1 - 0.048 12.5 0.3 1.6 7.5 0.3 2.3 1 1 1 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain HalOD1 PF18545.1 KOO33091.1 - 0.067 13.5 0.0 17 5.7 0.0 3.5 2 1 2 4 4 4 0 Halobacterial output domain 1 Proteasome_A_N PF10584.9 KOO33091.1 - 0.32 10.7 4.7 94 2.8 0.1 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF1769 PF08588.10 KOO33092.1 - 1.4e-05 25.2 0.0 0.00014 22.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1769) EF-hand_1 PF00036.32 KOO33093.1 - 8e-26 87.6 9.8 0.00023 20.5 0.0 7.3 5 2 2 7 7 7 6 EF hand EF-hand_7 PF13499.6 KOO33093.1 - 7.6e-22 77.5 4.6 0.0057 17.1 0.0 7.7 5 2 2 7 7 7 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO33093.1 - 3.9e-21 73.5 12.3 0.00022 20.6 0.3 6.0 4 2 2 6 6 6 5 EF hand EF-hand_6 PF13405.6 KOO33093.1 - 5e-20 69.7 12.1 0.013 15.4 0.1 8.6 7 2 2 9 9 9 6 EF-hand domain EF-hand_8 PF13833.6 KOO33093.1 - 1.5e-14 53.6 13.3 0.0016 18.2 0.3 6.9 5 1 1 6 6 6 5 EF-hand domain pair EF-hand_4 PF12763.7 KOO33093.1 - 0.0068 16.3 1.7 69 3.5 0.2 4.3 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand Excalibur PF05901.11 KOO33093.1 - 0.014 16.0 1.3 17 6.2 0.1 3.5 3 0 0 3 3 3 0 Excalibur calcium-binding domain Dioxygenase_N PF04444.14 KOO33093.1 - 0.091 12.6 0.0 22 5.0 0.0 3.2 3 0 0 3 3 3 0 Catechol dioxygenase N terminus EF-hand_9 PF14658.6 KOO33093.1 - 0.16 12.3 0.0 1.2e+02 3.2 0.0 4.3 5 0 0 5 5 5 0 EF-hand domain SHOCT PF09851.9 KOO33093.1 - 0.25 11.1 3.8 2.7 7.8 0.1 4.0 4 0 0 4 4 4 0 Short C-terminal domain Asp_Arg_Hydrox PF05118.15 KOO33094.1 - 1.5e-44 151.6 0.0 2e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Cupin_2 PF07883.11 KOO33094.1 - 0.0016 18.1 0.0 0.0035 17.0 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Surfac_D-trimer PF09006.11 KOO33095.1 - 5.8 6.9 8.4 0.25 11.3 0.8 2.8 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation CDC45 PF02724.14 KOO33097.1 - 0.33 9.2 2.8 0.46 8.7 2.8 1.1 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 KOO33097.1 - 0.57 10.3 11.4 1.2 9.2 11.4 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Ion_trans PF00520.31 KOO33098.1 - 1.1e-180 597.9 43.0 4.6e-52 176.7 9.2 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO33098.1 - 9e-11 41.4 0.0 2.5e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO33098.1 - 2.4e-10 39.7 36.9 3.3e-06 26.0 0.9 7.9 6 3 2 8 8 8 6 Polycystin cation channel DUF4834 PF16118.5 KOO33098.1 - 0.15 13.0 1.7 8.5 7.4 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) Metallophos_C PF14008.6 KOO33099.1 - 7e-12 46.0 0.2 3e-11 44.0 0.2 2.2 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 KOO33099.1 - 2.9e-09 37.7 0.0 4.6e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ion_trans_2 PF07885.16 KOO33100.1 - 1.2e-05 25.2 6.4 2.5e-05 24.2 6.4 1.5 1 0 0 1 1 1 1 Ion channel Filamin PF00630.19 KOO33101.1 - 8.5e-42 142.2 0.0 1.5e-14 54.7 0.0 5.9 5 1 0 5 5 5 5 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO33101.1 - 4e-12 46.3 0.0 0.00025 21.3 0.0 5.2 5 0 0 5 5 5 2 Invasin, domain 3 YtkA PF13115.6 KOO33101.1 - 0.0095 16.5 0.4 22 5.8 0.0 4.4 5 0 0 5 5 5 1 YtkA-like SH3_3 PF08239.11 KOO33101.1 - 0.04 14.2 0.1 0.28 11.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial SH3 domain CopC PF04234.12 KOO33101.1 - 0.088 13.9 0.0 36 5.5 0.0 3.5 3 0 0 3 3 3 0 CopC domain PCC_BT PF18140.1 KOO33101.1 - 0.096 13.0 0.0 5.7 7.3 0.0 3.5 4 0 0 4 4 4 0 Propionyl-coenzyme A carboxylase BT domain LRR_6 PF13516.6 KOO33103.1 - 1.7e-06 27.6 1.5 0.0027 17.6 0.1 3.5 3 0 0 3 3 3 2 Leucine Rich repeat LRR_5 PF13306.6 KOO33104.1 - 4.5e-60 201.2 0.6 6e-32 110.3 0.1 2.0 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO33104.1 - 1.1e-13 50.7 0.0 0.00033 20.4 0.0 4.1 1 1 3 4 4 4 4 Leucine rich repeat He_PIG PF05345.12 KOO33104.1 - 0.043 14.0 3.9 60 3.9 0.0 5.0 5 1 0 5 5 5 0 Putative Ig domain Ion_trans_2 PF07885.16 KOO33105.1 - 3.7e-30 103.7 12.0 2.3e-16 59.5 3.5 2.6 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 KOO33105.1 - 4.2e-10 39.3 3.8 6e-08 32.2 0.8 2.1 2 0 0 2 2 2 2 Ion transport protein EF-hand_5 PF13202.6 KOO33105.1 - 0.00027 20.3 2.7 0.056 13.0 0.5 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO33105.1 - 0.00046 20.6 1.7 0.16 12.4 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO33105.1 - 0.0026 17.5 0.4 0.12 12.3 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO33105.1 - 0.017 14.6 1.0 0.77 9.5 0.1 2.6 2 0 0 2 2 2 0 EF hand IRK PF01007.20 KOO33105.1 - 0.018 14.8 0.4 3.3 7.5 0.1 2.3 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain cNMP_binding PF00027.29 KOO33106.1 - 7.1e-10 38.8 0.1 1.6e-07 31.3 0.0 3.0 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain GAS PF13851.6 KOO33106.1 - 1.1 8.6 45.5 0.21 10.9 9.1 4.3 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding Lectin_C PF00059.21 KOO33107.1 - 0.016 15.9 0.0 0.04 14.6 0.0 1.6 1 0 0 1 1 1 0 Lectin C-type domain TIR_2 PF13676.6 KOO33107.1 - 0.15 12.7 0.0 0.29 11.8 0.0 1.5 1 0 0 1 1 1 0 TIR domain DUF724 PF05266.14 KOO33107.1 - 0.17 11.7 1.6 0.32 10.8 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PIN_9 PF18477.1 KOO33107.1 - 0.42 10.9 2.3 0.8 10.0 2.3 1.5 1 0 0 1 1 1 0 PIN like domain DUF1304 PF06993.12 KOO33107.1 - 0.51 10.3 5.9 1.7 8.7 5.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1304) PQQ_2 PF13360.6 KOO33109.1 - 3.9e-06 26.6 1.8 1.1e-05 25.2 1.7 1.8 1 1 0 1 1 1 1 PQQ-like domain PQQ_3 PF13570.6 KOO33109.1 - 0.0024 18.3 1.3 0.016 15.7 0.1 3.1 4 0 0 4 4 4 1 PQQ-like domain WD40 PF00400.32 KOO33109.1 - 0.11 13.5 7.9 52 4.9 1.9 4.8 4 1 0 4 4 4 0 WD domain, G-beta repeat PAP_fibrillin PF04755.12 KOO33111.1 - 1.2e-14 54.7 0.0 7.4e-14 52.1 0.0 1.9 1 1 0 1 1 1 1 PAP_fibrillin HTH_15 PF12324.8 KOO33111.1 - 0.11 12.5 0.3 0.31 11.0 0.3 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase FYVE PF01363.21 KOO33112.1 - 1.1e-12 47.9 7.2 1.9e-12 47.2 7.2 1.3 1 0 0 1 1 1 1 FYVE zinc finger WW PF00397.26 KOO33112.1 - 2.5e-05 24.3 0.0 5.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 WW domain FYVE_2 PF02318.16 KOO33112.1 - 0.072 13.3 3.6 0.12 12.5 3.6 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger Siva PF05458.12 KOO33112.1 - 0.5 10.0 4.1 1.1 8.9 4.1 1.6 1 1 0 1 1 1 0 Cd27 binding protein (Siva) Abhydrolase_6 PF12697.7 KOO33114.1 - 1.2e-16 62.0 5.0 1.4e-16 61.8 5.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO33114.1 - 1.3e-10 40.9 0.0 2.2e-09 36.9 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO33114.1 - 3.2e-08 33.5 0.0 2.2e-05 24.2 0.0 2.0 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 KOO33114.1 - 0.03 14.2 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold CDO_I PF05995.12 KOO33115.1 - 5.5e-18 64.8 0.0 7.2e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Cysteine dioxygenase type I Cupin_2 PF07883.11 KOO33115.1 - 0.0017 18.0 0.2 2.1 8.1 0.1 2.6 1 1 1 2 2 2 2 Cupin domain Glyco_hydro_3_C PF01915.22 KOO33117.1 - 7e-42 143.7 0.0 1.3e-41 142.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOO33117.1 - 4.8e-29 101.7 0.0 8.3e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOO33117.1 - 5.1e-12 45.7 0.0 1.1e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Radical_SAM PF04055.21 KOO33117.1 - 0.0022 18.4 0.0 0.0039 17.6 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily C_GCAxxG_C_C PF09719.10 KOO33117.1 - 2.6 8.4 5.8 4.2 7.7 1.6 3.2 3 1 1 4 4 4 0 Putative redox-active protein (C_GCAxxG_C_C) Pkinase PF00069.25 KOO33118.1 - 1.4e-36 126.2 0.0 2.2e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33118.1 - 2.9e-30 105.4 0.0 4.9e-30 104.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase LRS4 PF10422.9 KOO33119.1 - 0.086 12.4 16.0 0.083 12.5 14.1 1.9 1 1 1 2 2 2 0 Monopolin complex subunit LRS4 Eaf7 PF07904.13 KOO33119.1 - 1.9 8.9 5.5 4.6 7.7 5.5 1.7 1 1 0 1 1 1 0 Chromatin modification-related protein EAF7 Sulf_transp PF04143.14 KOO33120.1 - 1.7e-09 37.7 44.2 8e-08 32.2 14.4 2.9 2 1 1 3 3 3 2 Sulphur transport TPR_12 PF13424.6 KOO33121.1 - 3.5e-09 36.8 1.6 3.4e-08 33.7 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO33121.1 - 3.9e-06 26.6 1.3 0.0024 17.8 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33121.1 - 0.0008 19.1 5.4 0.0014 18.3 0.3 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO33121.1 - 0.0016 18.2 4.8 0.48 10.4 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO33121.1 - 0.0068 16.4 6.0 0.79 9.9 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO33121.1 - 0.012 16.1 2.8 3.5 8.2 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO33121.1 - 0.014 15.6 0.1 0.057 13.7 0.1 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1897 PF09005.10 KOO33121.1 - 0.36 10.3 3.3 0.44 10.1 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1897) FAM199X PF15814.5 KOO33121.1 - 2 7.4 10.0 4.2 6.3 10.0 1.5 1 0 0 1 1 1 0 Protein family FAM199X TPR_14 PF13428.6 KOO33121.1 - 3.4 8.7 8.8 22 6.2 0.7 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DNA_photolyase PF00875.18 KOO33122.1 - 5.1e-05 23.3 0.0 7.2e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 DNA photolyase CW_binding_2 PF04122.12 KOO33123.1 - 5.9 7.6 6.3 1e+02 3.7 0.1 3.2 1 1 0 2 2 2 0 Putative cell wall binding repeat 2 Peptidase_M16_C PF05193.21 KOO33124.1 - 3.5e-07 30.4 0.0 7.5e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOO33124.1 - 3.5e-06 27.1 0.0 6.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) WD40 PF00400.32 KOO33125.1 - 1.1e-27 95.7 6.2 2.4e-09 37.6 0.1 4.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO33125.1 - 8.4e-06 26.0 0.0 0.25 11.7 0.0 3.5 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO33125.1 - 4e-05 22.7 0.0 0.047 12.7 0.0 3.1 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KOO33125.1 - 0.00052 18.8 0.1 0.045 12.4 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Frtz PF11768.8 KOO33125.1 - 0.027 12.8 0.0 0.034 12.5 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO33125.1 - 0.089 12.1 0.3 0.77 9.0 0.0 2.3 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Peptidase_S41 PF03572.18 KOO33126.1 - 7.3e-21 74.4 0.0 1.1e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S41 VCBS PF13517.6 KOO33127.1 - 1.1e-126 413.4 143.0 7.1e-14 52.1 4.8 12.4 1 1 11 12 12 12 12 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO33127.1 - 9.5e-60 198.3 123.6 4.8e-05 23.4 2.5 13.6 13 0 0 13 13 13 13 FG-GAP repeat Dockerin_1 PF00404.18 KOO33127.1 - 2.4e-14 53.2 35.7 3.3 8.0 0.0 13.1 13 0 0 13 13 13 6 Dockerin type I domain HET-s_218-289 PF11558.8 KOO33127.1 - 1.9e-11 43.8 0.0 22 5.2 0.0 11.3 13 0 0 13 13 13 0 Het-s 218-289 TM_PBP2_N PF16296.5 KOO33127.1 - 3e-07 30.5 0.0 11 6.2 0.0 7.9 12 0 0 12 12 12 2 N-terminal of TM subunit in PBP-dependent ABC transporters Pkinase PF00069.25 KOO33127.1 - 1.6e-05 24.4 0.0 0.039 13.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain TcdB_toxin_midN PF12256.8 KOO33127.1 - 2.4e-05 23.8 59.8 2.9 7.2 0.2 12.8 5 3 8 13 13 13 8 Insecticide toxin TcdB middle/N-terminal region Pkinase_Tyr PF07714.17 KOO33127.1 - 0.0009 18.6 0.0 0.33 10.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase EF-hand_1 PF00036.32 KOO33127.1 - 0.76 9.5 60.0 33 4.3 0.2 13.0 13 0 0 13 13 13 0 EF hand SBBP PF06739.11 KOO33128.1 - 1.8e-13 50.2 38.9 0.0042 17.1 0.7 6.4 6 0 0 6 6 6 6 Beta-propeller repeat DUF3712 PF12505.8 KOO33128.1 - 0.0036 17.6 0.0 33 4.8 0.0 4.4 5 0 0 5 5 5 1 Protein of unknown function (DUF3712) Keratin_2_head PF16208.5 KOO33128.1 - 1 9.5 49.6 8.6 6.5 12.9 4.7 1 1 4 5 5 5 0 Keratin type II head E1-E2_ATPase PF00122.20 KOO33129.1 - 2.1e-37 128.4 0.1 4.3e-37 127.4 0.1 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 KOO33129.1 - 4.8e-12 46.6 8.4 5.7e-11 43.1 8.4 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase MerC PF03203.14 KOO33129.1 - 0.0096 16.4 2.1 0.0096 16.4 2.1 2.2 2 0 0 2 2 2 1 MerC mercury resistance protein Hydrolase_3 PF08282.12 KOO33129.1 - 0.016 15.0 0.2 0.025 14.3 0.2 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase CHAD PF05235.14 KOO33129.1 - 0.36 10.8 4.1 0.35 10.8 3.0 1.6 1 1 0 1 1 1 0 CHAD domain DUF805 PF05656.14 KOO33129.1 - 3.9 7.9 5.6 0.6 10.5 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF805) Sec39 PF08314.11 KOO33131.1 - 3e-06 26.0 0.0 4.4e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Secretory pathway protein Sec39 FlgT_M PF16539.5 KOO33132.1 - 0.00018 21.7 0.3 0.35 11.0 0.1 2.4 2 0 0 2 2 2 2 Flagellar assembly protein T, middle domain R3H PF01424.22 KOO33132.1 - 0.00099 19.0 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 R3H domain Pannexin_like PF12534.8 KOO33132.1 - 0.066 12.3 0.1 0.14 11.2 0.1 1.5 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 RRXRR PF14239.6 KOO33132.1 - 0.11 12.4 0.4 0.23 11.3 0.4 1.4 1 0 0 1 1 1 0 RRXRR protein FAM176 PF14851.6 KOO33132.1 - 0.77 9.4 3.5 18 5.0 0.4 2.5 2 0 0 2 2 2 0 FAM176 family FeoB_Cyto PF17910.1 KOO33132.1 - 1 10.0 3.7 0.57 10.8 0.6 2.0 2 0 0 2 2 2 0 FeoB cytosolic helical domain Glyco_trans_1_2 PF13524.6 KOO33133.1 - 5.7e-07 29.9 0.0 1.1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 AAA_12 PF13087.6 KOO33135.1 - 3.3e-14 53.0 0.0 5.8e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO33135.1 - 8.7e-13 48.6 0.2 2.4e-11 43.9 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOO33135.1 - 4.5e-07 29.8 0.0 0.0052 16.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KOO33135.1 - 6.3e-07 29.8 0.0 3e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 KOO33135.1 - 1.3e-06 28.4 0.0 0.004 17.0 0.0 2.5 2 0 0 2 2 2 2 Helicase AAA_22 PF13401.6 KOO33135.1 - 1.1e-05 25.8 0.0 0.0002 21.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 KOO33135.1 - 0.00011 21.8 0.0 0.00025 20.7 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 KOO33135.1 - 0.00012 21.9 0.0 0.00033 20.4 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_25 PF13481.6 KOO33135.1 - 0.00028 20.5 0.5 0.00086 18.9 0.1 2.0 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 KOO33135.1 - 0.00099 18.9 0.4 0.98 9.1 0.1 3.7 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 KOO33135.1 - 0.0075 16.7 0.6 0.14 12.5 0.0 2.9 3 0 0 3 3 2 1 AAA ATPase domain AAA_33 PF13671.6 KOO33135.1 - 0.0078 16.4 0.0 0.026 14.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 KOO33135.1 - 0.0091 15.4 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family PhoH PF02562.16 KOO33135.1 - 0.053 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 KOO33135.1 - 0.081 12.6 0.0 0.26 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 KOO33135.1 - 0.11 11.6 0.0 0.25 10.4 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 KOO33135.1 - 0.19 11.5 0.0 0.45 10.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Phage_head_chap PF11113.8 KOO33136.1 - 0.029 14.5 0.0 0.063 13.4 0.0 1.5 1 0 0 1 1 1 0 Head assembly gene product CLIP1_ZNF PF16641.5 KOO33136.1 - 0.03 14.2 0.2 0.051 13.5 0.2 1.4 1 0 0 1 1 1 0 CLIP1 zinc knuckle Trp_repressor PF01371.19 KOO33136.1 - 0.071 13.3 0.0 0.17 12.0 0.0 1.6 1 1 0 1 1 1 0 Trp repressor protein FATC PF02260.20 KOO33136.1 - 0.096 12.5 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 FATC domain Sacchrp_dh_NADP PF03435.18 KOO33137.1 - 0.068 13.4 0.1 0.26 11.5 0.1 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Septin PF00735.18 KOO33138.1 - 8.9e-29 100.6 0.0 5.2e-22 78.4 0.1 2.2 2 0 0 2 2 2 2 Septin G-alpha PF00503.20 KOO33138.1 - 1.2e-05 24.6 0.0 1.5e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit RsgA_GTPase PF03193.16 KOO33138.1 - 3e-05 24.0 0.0 0.13 12.1 0.0 3.2 3 0 0 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 KOO33138.1 - 0.00018 21.1 1.0 0.95 9.0 0.1 3.3 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KOO33138.1 - 0.0002 21.8 5.3 0.00038 20.9 5.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOO33138.1 - 0.00037 20.8 0.2 0.0012 19.1 0.2 1.9 1 1 0 1 1 1 1 AAA domain DUF572 PF04502.13 KOO33138.1 - 0.00055 19.7 4.7 0.00066 19.4 4.7 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF572) MMR_HSR1 PF01926.23 KOO33138.1 - 0.00058 19.9 0.0 0.025 14.6 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KOO33138.1 - 0.00059 20.4 0.0 0.00093 19.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter Dynamin_N PF00350.23 KOO33138.1 - 0.0015 18.6 0.5 0.011 15.8 0.5 2.3 1 1 0 1 1 1 1 Dynamin family TMF_DNA_bd PF12329.8 KOO33138.1 - 0.0016 18.4 7.1 0.0037 17.2 7.1 1.7 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding AAA_24 PF13479.6 KOO33138.1 - 0.0043 16.8 0.5 0.35 10.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KOO33138.1 - 0.005 16.4 0.0 0.0096 15.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region MCM PF00493.23 KOO33138.1 - 0.029 13.5 0.0 0.059 12.5 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain NB-ARC PF00931.22 KOO33138.1 - 0.031 13.5 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 KOO33138.1 - 0.053 13.4 0.6 0.25 11.2 0.3 2.3 2 1 0 2 2 2 0 NACHT domain AAA_29 PF13555.6 KOO33138.1 - 0.087 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Spc7 PF08317.11 KOO33138.1 - 0.11 11.4 12.2 0.19 10.5 12.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Pox_A32 PF04665.12 KOO33138.1 - 0.11 11.9 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein DUF4407 PF14362.6 KOO33138.1 - 0.12 11.7 8.8 0.2 11.0 8.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 KOO33138.1 - 0.13 11.3 8.0 0.2 10.7 8.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PAS_4 PF08448.10 KOO33138.1 - 0.16 12.3 8.3 0.74 10.1 0.2 2.5 1 1 1 2 2 2 0 PAS fold TMPIT PF07851.13 KOO33138.1 - 0.2 10.9 0.4 0.29 10.3 0.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein Herpes_UL25 PF01499.16 KOO33138.1 - 0.22 10.0 8.3 0.31 9.5 8.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family AAA PF00004.29 KOO33138.1 - 0.35 11.3 1.6 4 7.9 0.2 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF724 PF05266.14 KOO33138.1 - 0.4 10.5 6.6 0.93 9.3 6.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Macoilin PF09726.9 KOO33138.1 - 1.2 7.6 8.3 1.8 7.1 8.3 1.2 1 0 0 1 1 1 0 Macoilin family Fib_alpha PF08702.10 KOO33138.1 - 3 8.0 7.2 0.53 10.5 2.7 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.19 KOO33138.1 - 3.6 5.4 4.8 5.8 4.7 4.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Med9 PF07544.13 KOO33138.1 - 4.2 7.5 10.5 8 6.6 9.2 2.1 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DivIC PF04977.15 KOO33138.1 - 9.9 6.0 14.4 0.31 10.9 5.3 2.6 1 1 2 3 3 3 0 Septum formation initiator IQ PF00612.27 KOO33141.1 - 0.0048 16.6 0.0 0.024 14.4 0.0 2.3 1 0 0 1 1 1 1 IQ calmodulin-binding motif RasGAP PF00616.19 KOO33142.1 - 1.2e-30 106.8 0.0 2.4e-30 105.8 0.0 1.5 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Sensor PF13796.6 KOO33142.1 - 0.68 10.0 5.7 0.11 12.6 0.7 2.1 3 0 0 3 3 3 0 Putative sensor Tubulin PF00091.25 KOO33143.1 - 3.3e-08 34.0 0.1 7.6e-08 32.8 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain EF-hand_1 PF00036.32 KOO33144.1 - 4.9e-23 78.9 0.9 2.7e-06 26.5 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO33144.1 - 5.3e-21 74.8 5.7 7.6e-10 39.1 0.1 3.0 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO33144.1 - 2.1e-19 67.7 0.3 1.9e-05 24.2 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KOO33144.1 - 3e-19 67.6 2.2 2.8e-06 26.5 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO33144.1 - 8.7e-14 51.1 2.2 0.00016 21.5 0.1 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 KOO33144.1 - 7.2e-06 25.9 0.3 2.1 8.4 0.0 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO33144.1 - 3.3e-05 24.1 0.6 0.024 15.0 0.0 2.7 3 0 0 3 3 2 2 EF-hand domain p25-alpha PF05517.12 KOO33144.1 - 0.0007 19.8 4.3 0.0095 16.1 0.1 2.7 1 1 2 3 3 3 2 p25-alpha SPARC_Ca_bdg PF10591.9 KOO33144.1 - 0.0043 17.3 3.2 2 8.8 0.0 3.0 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region COMMD1_N PF17221.3 KOO33144.1 - 0.032 14.5 0.3 3.6 7.9 0.0 2.6 1 1 0 2 2 2 0 COMMD1 N-terminal domain EspA PF03433.13 KOO33144.1 - 0.034 14.0 1.0 0.18 11.6 1.0 2.2 1 1 0 1 1 1 0 EspA-like secreted protein VIT1 PF01988.19 KOO33144.1 - 0.25 11.2 1.3 0.28 11.0 1.3 1.2 1 1 0 1 1 1 0 VIT family DUF4690 PF15756.5 KOO33145.1 - 0.002 18.7 2.6 0.0023 18.5 2.6 1.3 1 1 0 1 1 1 1 Small Novel Rich in Cartilage Rax2 PF12768.7 KOO33145.1 - 0.11 11.9 0.1 0.12 11.9 0.1 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity ASFV_J13L PF05568.11 KOO33145.1 - 0.36 10.5 0.1 0.36 10.5 0.1 2.1 2 1 0 2 2 2 0 African swine fever virus J13L protein Tubulin PF00091.25 KOO33146.1 - 1.6e-06 28.5 0.8 1.6e-06 28.4 0.8 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 KOO33146.1 - 0.0024 18.2 0.0 0.0024 18.2 0.0 1.0 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain VCBS PF13517.6 KOO33148.1 - 7.9e-136 442.7 151.4 2.4e-14 53.6 3.4 13.7 1 1 12 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO33148.1 - 1.3e-58 194.6 142.6 6.7e-05 22.9 3.0 15.9 15 0 0 15 15 15 14 FG-GAP repeat Pkinase PF00069.25 KOO33148.1 - 1.4e-29 103.3 0.0 6.7e-15 55.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33148.1 - 2.4e-27 95.9 0.0 3.5e-27 95.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Dockerin_1 PF00404.18 KOO33148.1 - 4e-09 36.5 34.2 12 6.2 0.0 13.9 14 0 0 14 14 14 1 Dockerin type I domain Tudor_3 PF18115.1 KOO33148.1 - 3.5e-06 26.8 0.1 0.14 12.0 0.0 3.4 4 0 0 4 4 4 2 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 KOO33148.1 - 0.013 15.6 0.0 0.051 13.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4537) TcdB_toxin_midN PF12256.8 KOO33148.1 - 0.13 11.6 62.7 3.4 7.0 0.1 13.2 2 2 12 14 14 14 0 Insecticide toxin TcdB middle/N-terminal region DUF5348 PF17295.2 KOO33148.1 - 0.18 11.8 0.0 19 5.2 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF5348) Nuc_sug_transp PF04142.15 KOO33149.1 - 5.6e-43 147.3 11.7 7.1e-43 147.0 11.7 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 KOO33149.1 - 1.4e-07 31.1 6.5 1.4e-07 31.1 6.5 1.5 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport EamA PF00892.20 KOO33149.1 - 0.00013 22.2 7.4 0.00013 22.2 7.4 3.6 2 2 0 2 2 2 1 EamA-like transporter family UAA PF08449.11 KOO33149.1 - 0.00091 18.5 1.2 0.0015 17.8 1.2 1.3 1 0 0 1 1 1 1 UAA transporter family MFS_1 PF07690.16 KOO33150.1 - 4.9e-20 71.8 29.8 4.9e-20 71.8 29.8 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily ACBP PF00887.19 KOO33150.1 - 3.9e-16 59.0 0.0 6.3e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein Sugar_tr PF00083.24 KOO33150.1 - 5.1e-09 35.5 7.7 5.1e-09 35.5 7.7 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 KOO33150.1 - 1.9e-07 29.8 3.0 3.4e-07 28.9 3.0 1.4 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family FoP_duplication PF13865.6 KOO33150.1 - 0.18 12.3 5.5 0.29 11.7 5.5 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 TTL PF03133.15 KOO33154.1 - 1.2e-74 251.2 0.0 1.6e-74 250.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO33154.1 - 0.00035 19.9 0.0 0.011 14.9 0.0 2.6 2 1 1 3 3 3 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO33154.1 - 0.0019 17.5 0.0 0.044 13.0 0.0 2.3 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 KOO33154.1 - 0.039 14.0 0.0 0.25 11.4 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain Mg_trans_NIPA PF05653.14 KOO33156.1 - 3.1e-11 42.9 13.2 7.2e-08 31.9 4.4 2.2 2 0 0 2 2 2 2 Magnesium transporter NIPA Nucleotid_trans PF03407.16 KOO33156.1 - 7.1e-06 26.1 0.1 1.1e-05 25.5 0.1 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase EamA PF00892.20 KOO33156.1 - 0.02 15.0 4.7 0.02 15.0 4.7 3.0 3 0 0 3 3 3 0 EamA-like transporter family Glyco_hydro_92 PF07971.12 KOO33158.1 - 4.9e-87 292.8 1.1 1e-86 291.7 0.8 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 KOO33158.1 - 1.5e-15 57.7 2.8 3.3e-15 56.7 2.8 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Chloroa_b-bind PF00504.21 KOO33159.1 - 3.2e-14 53.8 0.0 4.2e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein bZIP_1 PF00170.21 KOO33160.1 - 1e-09 38.3 7.3 1.5e-09 37.8 7.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KOO33160.1 - 2.3e-07 30.8 8.4 3.9e-07 30.0 8.4 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KOO33160.1 - 2.1e-05 24.9 3.3 3.5e-05 24.3 3.3 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Spc7 PF08317.11 KOO33160.1 - 0.009 14.9 1.0 0.013 14.4 1.0 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein GvpL_GvpF PF06386.11 KOO33160.1 - 0.014 15.4 2.1 0.023 14.6 2.1 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF TSC22 PF01166.18 KOO33160.1 - 0.027 14.8 0.1 0.055 13.8 0.1 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family Vps5 PF09325.10 KOO33160.1 - 0.029 13.9 0.3 0.046 13.3 0.3 1.2 1 0 0 1 1 1 0 Vps5 C terminal like DUF4618 PF15397.6 KOO33160.1 - 0.047 13.1 0.4 0.065 12.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) LPP PF04728.13 KOO33160.1 - 0.065 13.6 1.3 0.15 12.5 1.3 1.6 1 0 0 1 1 1 0 Lipoprotein leucine-zipper DUF3138 PF11336.8 KOO33160.1 - 0.56 8.8 1.4 0.88 8.1 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) PAH PF02671.21 KOO33161.1 - 1.6e-16 60.2 1.0 2.9e-16 59.3 1.0 1.5 1 0 0 1 1 1 1 Paired amphipathic helix repeat PHD PF00628.29 KOO33161.1 - 2.4e-08 33.7 8.6 2.4e-08 33.7 8.6 2.6 3 0 0 3 3 3 1 PHD-finger zf-CXXC PF02008.20 KOO33161.1 - 1.9e-05 24.6 0.2 1.9e-05 24.6 0.2 2.9 4 0 0 4 4 4 1 CXXC zinc finger domain FCH PF00611.23 KOO33161.1 - 0.012 15.9 2.2 0.58 10.5 0.2 3.1 3 0 0 3 3 3 0 Fes/CIP4, and EFC/F-BAR homology domain Carbpep_Y_N PF05388.11 KOO33161.1 - 0.028 15.0 0.6 3.3 8.3 0.1 2.6 2 1 0 2 2 2 0 Carboxypeptidase Y pro-peptide PHD_Oberon PF07227.11 KOO33161.1 - 0.058 13.3 5.7 0.11 12.4 3.7 2.4 2 0 0 2 2 2 0 PHD - plant homeodomain finger protein zf-CW PF07496.15 KOO33161.1 - 0.19 11.8 4.6 0.65 10.1 4.6 2.0 1 0 0 1 1 1 0 CW-type Zinc Finger OAM_dimer PF16554.5 KOO33161.1 - 5.5 7.5 5.1 6.2 7.4 0.4 3.1 2 1 1 3 3 3 0 Dimerisation domain of d-ornithine 4,5-aminomutase Ank_2 PF12796.7 KOO33162.1 - 6.8e-30 103.5 2.0 8e-16 58.4 0.0 4.2 2 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33162.1 - 3e-22 78.7 0.3 1.3e-07 32.0 0.0 5.7 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33162.1 - 7.8e-19 65.8 6.2 0.005 17.3 0.0 7.5 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 KOO33162.1 - 1.9e-17 63.1 4.6 0.00014 22.1 0.0 6.0 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 KOO33162.1 - 7.3e-16 57.8 10.5 0.07 13.6 0.0 6.8 6 0 0 6 6 6 5 Ankyrin repeat zf-PARP PF00645.18 KOO33163.1 - 3.1e-17 63.2 0.0 6.1e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region SAP PF02037.27 KOO33163.1 - 3.8e-12 45.7 2.0 5.8e-08 32.3 0.1 2.4 2 0 0 2 2 2 2 SAP domain PADR1 PF08063.12 KOO33163.1 - 1.9e-10 40.3 1.0 1.9e-10 40.3 1.0 1.9 2 1 0 2 2 2 1 PADR1 (NUC008) domain HeH PF12949.7 KOO33163.1 - 0.012 15.3 0.2 0.063 13.0 0.0 2.3 2 1 0 2 2 2 0 HeH/LEM domain DNA_ligase_ZBD PF03119.16 KOO33163.1 - 0.099 12.7 0.7 0.38 10.8 0.4 2.2 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-RING_7 PF02591.15 KOO33163.1 - 0.11 12.7 0.6 0.9 9.8 0.2 2.4 2 0 0 2 2 2 0 C4-type zinc ribbon domain zf-Dof PF02701.15 KOO33163.1 - 0.69 10.1 2.8 3.9 7.7 0.0 2.8 3 0 0 3 3 3 0 Dof domain, zinc finger Aa_trans PF01490.18 KOO33164.1 - 6.2e-44 150.3 9.4 7.8e-44 150.0 9.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Cyt-b5 PF00173.28 KOO33165.1 - 1.9e-17 63.2 0.0 2.5e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain WW PF00397.26 KOO33165.1 - 5.3e-05 23.2 0.0 0.0001 22.3 0.0 1.5 1 0 0 1 1 1 1 WW domain Multi_Drug_Res PF00893.19 KOO33166.1 - 0.00025 21.7 0.5 0.0004 21.0 0.5 1.3 1 0 0 1 1 1 1 Small Multidrug Resistance protein Sugar_tr PF00083.24 KOO33166.1 - 0.00077 18.4 0.1 0.00077 18.4 0.1 1.5 2 0 0 2 2 2 1 Sugar (and other) transporter DivIC PF04977.15 KOO33166.1 - 0.0061 16.3 0.6 0.0061 16.3 0.6 4.1 2 2 1 4 4 4 1 Septum formation initiator YabA PF06156.13 KOO33166.1 - 0.027 15.1 8.1 0.74 10.5 4.0 3.0 2 1 0 2 2 2 0 Initiation control protein YabA bZIP_2 PF07716.15 KOO33166.1 - 0.029 14.5 1.6 0.029 14.5 1.6 3.9 3 2 1 4 4 4 0 Basic region leucine zipper MRP-S27 PF10037.9 KOO33166.1 - 0.086 11.7 14.0 0.019 13.9 9.4 1.8 1 1 1 2 2 2 0 Mitochondrial 28S ribosomal protein S27 Prominin PF05478.11 KOO33166.1 - 0.1 10.6 6.4 0.13 10.2 6.4 1.2 1 0 0 1 1 1 0 Prominin BAR_3 PF16746.5 KOO33166.1 - 0.14 11.8 6.4 0.12 12.0 5.1 1.5 1 1 0 1 1 1 0 BAR domain of APPL family GAS PF13851.6 KOO33166.1 - 0.16 11.3 21.1 0.7 9.2 13.0 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Fungal_TACC PF12709.7 KOO33166.1 - 0.2 12.1 4.6 8.4 6.9 0.1 2.9 2 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF4618 PF15397.6 KOO33166.1 - 0.7 9.3 16.7 0.018 14.5 9.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF4145 PF13643.6 KOO33166.1 - 1.3 9.2 7.7 0.17 12.0 1.8 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4145) PI3K_P85_iSH2 PF16454.5 KOO33166.1 - 2.3 7.8 16.7 0.14 11.7 6.8 2.7 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Hamartin PF04388.12 KOO33166.1 - 4.4 5.9 12.3 5.4 5.6 12.3 1.0 1 0 0 1 1 1 0 Hamartin protein DUF3138 PF11336.8 KOO33166.1 - 4.7 5.7 15.5 0.41 9.2 10.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) DUF3450 PF11932.8 KOO33166.1 - 9.2 5.5 25.4 0.36 10.1 8.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) GalKase_gal_bdg PF10509.9 KOO33168.1 - 3.1e-07 29.9 0.0 7.7e-07 28.6 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 KOO33168.1 - 0.00017 21.9 0.2 0.00052 20.3 0.2 1.9 1 1 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 KOO33168.1 - 0.0016 18.7 0.7 0.0077 16.4 0.7 2.3 1 0 0 1 1 1 1 GHMP kinases N terminal domain EF-hand_8 PF13833.6 KOO33170.1 - 3.1e-14 52.6 7.6 9.7e-12 44.6 1.2 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO33170.1 - 7.7e-14 50.1 3.8 4.7e-07 28.9 0.5 2.9 2 0 0 2 2 2 2 EF hand PH PF00169.29 KOO33170.1 - 1.4e-13 51.3 0.1 2.6e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 PH domain EF-hand_7 PF13499.6 KOO33170.1 - 5.8e-11 42.7 2.7 1.2e-10 41.7 0.8 2.4 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO33170.1 - 1.8e-10 39.8 5.8 2.1e-06 27.2 0.2 2.9 3 0 0 3 3 3 2 EF-hand domain PDZ PF00595.24 KOO33170.1 - 8.7e-05 22.8 0.0 0.00017 21.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain EF-hand_5 PF13202.6 KOO33170.1 - 0.00011 21.5 6.1 0.0011 18.4 0.5 3.2 4 0 0 4 4 4 2 EF hand PDZ_6 PF17820.1 KOO33170.1 - 0.00039 20.2 0.1 0.0014 18.5 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PH_8 PF15409.6 KOO33170.1 - 0.0034 17.6 0.0 0.0062 16.8 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KOO33170.1 - 0.011 16.2 2.1 0.024 15.0 2.0 1.6 1 1 0 1 1 1 0 Pleckstrin homology domain Dockerin_1 PF00404.18 KOO33170.1 - 0.034 14.3 0.2 0.065 13.4 0.2 1.5 1 0 0 1 1 1 0 Dockerin type I domain PDZ_2 PF13180.6 KOO33170.1 - 0.057 13.8 0.0 0.2 12.0 0.0 1.9 2 0 0 2 2 2 0 PDZ domain Mcp5_PH PF12814.7 KOO33170.1 - 0.16 12.1 0.1 0.31 11.2 0.1 1.6 1 1 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Pectate_lyase_3 PF12708.7 KOO33171.1 - 0.013 15.4 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Pectate lyase superfamily protein Guanylate_cyc PF00211.20 KOO33172.1 - 8.7e-20 71.1 0.0 5.8e-11 42.4 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain cNMP_binding PF00027.29 KOO33172.1 - 1.2e-15 57.4 0.1 2.8e-15 56.2 0.1 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Sel1 PF08238.12 KOO33172.1 - 0.047 14.4 0.6 0.2 12.4 0.0 2.5 3 0 0 3 3 3 0 Sel1 repeat TPR_12 PF13424.6 KOO33172.1 - 0.19 12.1 13.5 1.9 8.8 0.1 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat MukE PF04288.13 KOO33173.1 - 0.048 12.6 0.0 0.081 11.8 0.0 1.3 1 0 0 1 1 1 0 MukE-like family HATPase_c_3 PF13589.6 KOO33173.1 - 0.067 13.0 0.0 2.7 7.8 0.0 2.3 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HlyIII PF03006.20 KOO33174.1 - 2.4e-12 47.1 9.0 2.8e-12 46.8 9.0 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF1129 PF06570.11 KOO33174.1 - 0.0042 16.6 0.7 0.0062 16.1 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) TT_ORF2 PF02957.15 KOO33174.1 - 2.5 9.0 3.4 0.64 10.9 0.5 1.5 2 0 0 2 2 2 0 TT viral ORF2 Pkinase PF00069.25 KOO33175.1 - 2.1e-34 119.1 0.0 3e-34 118.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33175.1 - 1e-20 74.2 0.0 3.4e-20 72.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO33175.1 - 0.021 14.7 0.2 0.29 11.0 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family AA_permease_2 PF13520.6 KOO33177.1 - 2.6e-41 141.9 18.1 3.3e-41 141.5 18.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOO33177.1 - 2.8e-24 85.6 13.2 3.9e-24 85.1 13.2 1.1 1 0 0 1 1 1 1 Amino acid permease Mg_trans_NIPA PF05653.14 KOO33178.1 - 3.7e-18 65.7 12.7 7.8e-17 61.3 9.7 2.1 1 1 1 2 2 2 2 Magnesium transporter NIPA FHA PF00498.26 KOO33179.1 - 1.7e-05 25.1 0.0 2.8e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 FHA domain PEP-utilisers_N PF05524.13 KOO33180.1 - 0.0063 16.7 2.4 0.074 13.2 0.1 2.3 2 0 0 2 2 2 1 PEP-utilising enzyme, N-terminal Nsp1_C PF05064.13 KOO33180.1 - 0.032 14.0 0.6 0.18 11.6 0.0 2.0 1 1 1 2 2 2 0 Nsp1-like C-terminal region DUF1664 PF07889.12 KOO33180.1 - 0.055 13.5 2.5 0.2 11.7 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF5601 PF18151.1 KOO33180.1 - 0.15 12.4 1.5 1.6 9.1 0.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF5601) ATP-synt_D PF01813.17 KOO33180.1 - 0.16 11.8 1.0 2.7 7.8 0.1 2.2 1 1 1 2 2 2 0 ATP synthase subunit D SIKE PF05769.11 KOO33180.1 - 0.44 10.5 3.6 0.75 9.7 0.2 2.1 1 1 0 2 2 2 0 SIKE family LRR_5 PF13306.6 KOO33181.1 - 9.2e-100 329.5 0.0 3.2e-38 130.6 0.0 2.9 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO33181.1 - 5.2e-14 51.8 0.0 0.11 12.3 0.0 6.4 2 1 7 9 9 9 7 Leucine rich repeat Myosin_head PF00063.21 KOO33182.1 - 2e-161 538.6 0.0 2.8e-65 220.9 0.0 4.8 3 1 1 4 4 4 4 Myosin head (motor domain) AAA_16 PF13191.6 KOO33182.1 - 0.0099 16.3 0.0 0.0099 16.3 0.0 3.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOO33182.1 - 0.025 14.8 2.5 0.15 12.4 0.0 3.0 3 0 0 3 3 3 0 AAA domain Hpr_kinase_C PF07475.12 KOO33182.1 - 0.066 12.7 0.0 0.69 9.4 0.0 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Mitoc_L55 PF09776.9 KOO33183.1 - 2.4e-05 24.0 0.1 7.5 6.3 0.0 4.1 1 1 3 4 4 4 4 Mitochondrial ribosomal protein L55 LRR_5 PF13306.6 KOO33184.1 - 1.3e-167 548.9 1.0 2.8e-39 134.0 0.1 3.9 1 1 4 5 5 5 5 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO33184.1 - 8.4e-21 73.5 0.0 0.14 11.9 0.0 9.0 3 1 7 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 KOO33184.1 - 0.025 15.0 2.4 2.3e+02 2.4 0.1 6.6 6 2 1 7 7 7 0 Leucine Rich repeats (2 copies) Transp_Tc5_C PF04236.15 KOO33184.1 - 0.047 14.1 4.5 7.6 7.0 0.1 4.3 4 0 0 4 4 4 0 Tc5 transposase C-terminal domain GATase_7 PF13537.6 KOO33185.1 - 0.048 13.6 0.0 0.088 12.7 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferase domain PUB PF09409.10 KOO33186.1 - 4e-27 94.0 0.1 1.2e-12 47.6 0.0 2.4 2 0 0 2 2 2 2 PUB domain OTU PF02338.19 KOO33186.1 - 2.8e-14 53.7 0.0 5.6e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease Leptin PF02024.15 KOO33186.1 - 0.012 15.3 0.3 0.3 10.9 0.0 2.9 3 0 0 3 3 3 0 Leptin TUDOR_5 PF18359.1 KOO33186.1 - 0.019 14.6 0.0 0.14 11.9 0.0 2.2 2 0 0 2 2 2 0 Histone methyltransferase Tudor domain 1 Agenet PF05641.12 KOO33186.1 - 0.021 15.3 0.2 1.5 9.4 0.0 2.5 2 0 0 2 2 2 0 Agenet domain GM_CSF PF01109.17 KOO33187.1 - 0.0042 17.3 0.0 0.21 11.8 0.0 2.2 2 0 0 2 2 2 1 Granulocyte-macrophage colony-stimulating factor CW_binding_2 PF04122.12 KOO33187.1 - 0.098 13.3 0.1 0.25 12.0 0.1 1.8 1 0 0 1 1 1 0 Putative cell wall binding repeat 2 DUF5471 PF17565.2 KOO33187.1 - 0.3 11.4 2.1 0.96 9.8 2.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5471) PUB PF09409.10 KOO33188.1 - 1.1e-16 60.5 0.1 2.7e-16 59.3 0.1 1.5 1 0 0 1 1 1 1 PUB domain OTU PF02338.19 KOO33188.1 - 4.1e-15 56.4 0.0 7.9e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Pkinase PF00069.25 KOO33189.1 - 9.5e-57 192.4 0.0 1.2e-56 192.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33189.1 - 3.8e-28 98.5 0.0 5.3e-28 98.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_6 PF13516.6 KOO33189.1 - 6e-09 35.3 15.3 8.1e-05 22.4 0.3 4.9 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 KOO33189.1 - 7.7e-05 23.0 3.1 0.074 13.5 0.2 2.6 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) Haspin_kinase PF12330.8 KOO33189.1 - 0.0057 15.7 0.1 0.0085 15.1 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOO33189.1 - 0.043 13.2 0.1 0.074 12.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_8 PF13855.6 KOO33189.1 - 1 9.2 6.5 15 5.4 3.2 3.1 1 1 1 2 2 2 0 Leucine rich repeat DUF812 PF05667.11 KOO33190.1 - 1.7 7.4 28.3 4.2 6.1 28.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF812) EF-hand_7 PF13499.6 KOO33191.1 - 6.3e-23 81.0 13.2 1.7e-06 28.3 1.2 5.6 3 1 2 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.32 KOO33191.1 - 4e-18 63.5 16.2 0.00023 20.5 0.5 6.7 7 0 0 7 7 7 5 EF hand EF-hand_6 PF13405.6 KOO33191.1 - 5.1e-16 57.2 18.2 0.0013 18.5 0.1 7.1 6 1 1 7 7 7 5 EF-hand domain EF-hand_8 PF13833.6 KOO33191.1 - 6.5e-13 48.3 11.4 0.00011 21.9 0.2 5.6 5 1 1 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO33191.1 - 6.3e-05 22.3 20.6 0.0061 16.0 0.9 6.0 7 0 0 7 7 7 3 EF hand SPARC_Ca_bdg PF10591.9 KOO33191.1 - 0.056 13.8 1.9 0.45 10.9 0.2 3.2 4 0 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO33191.1 - 0.06 13.2 6.9 4.4 7.2 0.0 4.2 5 0 0 5 5 5 0 EF hand CDP-OH_P_transf PF01066.21 KOO33192.1 - 1.2e-08 35.5 1.9 9.4e-08 32.7 0.0 2.8 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase Trp_oprn_chp PF09534.10 KOO33192.1 - 0.12 12.2 0.1 0.12 12.2 0.1 2.6 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Ig_mannosidase PF17753.1 KOO33193.1 - 3.3e-10 39.6 0.0 7.7e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 Ig-fold domain PAN_1 PF00024.26 KOO33193.1 - 0.00012 22.0 0.3 0.00029 20.8 0.3 1.6 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 KOO33193.1 - 0.00023 21.0 1.8 0.0006 19.7 1.8 1.7 1 0 0 1 1 1 1 PAN domain Glyco_hydro_2_N PF02837.18 KOO33193.1 - 0.00084 19.3 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 KOO33193.1 - 0.02 14.0 0.0 0.039 13.1 0.0 1.5 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain BetaGal_dom4_5 PF13364.6 KOO33193.1 - 0.16 12.6 0.6 0.97 10.0 0.0 2.5 3 0 0 3 3 3 0 Beta-galactosidase jelly roll domain Methyltransf_31 PF13847.6 KOO33194.1 - 9.7e-07 28.7 0.0 1.6e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO33194.1 - 9.9e-07 29.4 0.0 4e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOO33194.1 - 9.7e-06 25.2 0.0 0.00069 19.1 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_11 PF08241.12 KOO33194.1 - 0.00023 21.8 0.0 0.00042 20.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO33194.1 - 0.00039 21.1 0.0 0.00074 20.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO33194.1 - 0.00062 19.4 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 KOO33194.1 - 0.06 13.2 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Toprim_N PF08275.11 KOO33195.1 - 5.2e-28 97.6 0.0 9e-28 96.9 0.0 1.3 1 0 0 1 1 1 1 DNA primase catalytic core, N-terminal domain zf-CHC2 PF01807.20 KOO33195.1 - 1.8e-20 72.5 0.0 3.3e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 CHC2 zinc finger Toprim_2 PF13155.6 KOO33195.1 - 8.7e-17 61.3 0.0 2.3e-16 60.0 0.0 1.8 1 0 0 1 1 1 1 Toprim-like Toprim_4 PF13662.6 KOO33195.1 - 1.6e-14 54.1 0.0 4e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 Toprim domain Toprim_3 PF13362.6 KOO33195.1 - 4.9e-08 33.2 0.2 2.8e-07 30.8 0.0 2.4 2 0 0 2 2 2 1 Toprim domain Toprim PF01751.22 KOO33195.1 - 9.3e-06 25.8 0.0 3.5e-05 24.0 0.0 2.0 1 0 0 1 1 1 1 Toprim domain AAA PF00004.29 KOO33196.1 - 1.4e-88 294.1 0.0 2.4e-43 147.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO33196.1 - 1.4e-22 79.2 4.0 3.4e-12 46.0 0.4 2.8 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 KOO33196.1 - 4.6e-15 55.7 0.0 1.3e-07 31.5 0.0 3.1 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KOO33196.1 - 3.9e-13 49.9 0.0 1.7e-06 28.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOO33196.1 - 1.2e-12 48.6 0.6 0.00011 22.7 0.1 3.9 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 KOO33196.1 - 1.6e-12 47.6 0.1 1.8e-06 28.0 0.0 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO33196.1 - 1.1e-09 38.7 0.7 0.015 15.6 0.1 3.8 2 2 1 3 3 3 2 AAA domain TIP49 PF06068.13 KOO33196.1 - 2.4e-09 36.9 0.0 0.00052 19.3 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 KOO33196.1 - 6.4e-08 32.9 0.0 0.0019 18.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 KOO33196.1 - 1.5e-07 31.5 0.0 0.0064 16.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 KOO33196.1 - 5.2e-07 30.0 0.0 0.0049 17.2 0.0 3.2 3 0 0 3 3 2 2 RNA helicase AAA_18 PF13238.6 KOO33196.1 - 7.7e-07 29.7 0.0 0.021 15.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 KOO33196.1 - 9.4e-07 29.4 0.0 0.0051 17.3 0.0 2.7 2 1 0 2 2 2 2 ABC transporter Mg_chelatase PF01078.21 KOO33196.1 - 1.1e-06 28.2 0.1 0.0096 15.3 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 KOO33196.1 - 1.5e-06 28.3 0.0 0.08 13.1 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 KOO33196.1 - 4.3e-06 26.5 0.6 1 8.9 0.0 3.6 2 1 1 3 3 3 1 AAA domain Sigma54_activat PF00158.26 KOO33196.1 - 4.3e-06 26.5 0.1 0.061 13.0 0.0 3.5 3 1 0 3 3 3 2 Sigma-54 interaction domain AAA_7 PF12775.7 KOO33196.1 - 6.4e-06 25.8 0.1 0.05 13.1 0.0 2.8 3 0 0 3 3 3 2 P-loop containing dynein motor region Zeta_toxin PF06414.12 KOO33196.1 - 8.1e-06 25.2 0.6 0.059 12.6 0.0 2.8 3 0 0 3 3 2 2 Zeta toxin IstB_IS21 PF01695.17 KOO33196.1 - 2.5e-05 24.1 0.1 0.15 11.8 0.1 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_24 PF13479.6 KOO33196.1 - 2.7e-05 24.0 0.0 0.15 11.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 KOO33196.1 - 3.4e-05 23.8 0.0 0.037 13.9 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain Vps4_C PF09336.10 KOO33196.1 - 3.9e-05 23.5 0.6 0.0011 18.9 0.1 3.1 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain TsaE PF02367.17 KOO33196.1 - 5.2e-05 23.2 0.0 0.22 11.5 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 KOO33196.1 - 5.3e-05 23.2 0.1 0.53 10.2 0.0 3.0 3 0 0 3 3 3 2 NACHT domain CDC48_N PF02359.18 KOO33196.1 - 8.5e-05 22.7 0.2 0.00029 20.9 0.2 1.9 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain ATPase PF06745.13 KOO33196.1 - 9.4e-05 21.9 0.1 6.4 6.0 0.0 3.3 3 0 0 3 3 3 0 KaiC AAA_28 PF13521.6 KOO33196.1 - 0.00017 21.9 0.0 0.32 11.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 KOO33196.1 - 0.00017 22.0 0.0 0.22 12.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain Molydop_binding PF01568.21 KOO33196.1 - 0.00075 19.5 0.2 0.0017 18.4 0.2 1.5 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Bac_DnaA PF00308.18 KOO33196.1 - 0.00095 19.1 0.1 0.25 11.1 0.0 2.6 3 0 0 3 3 2 1 Bacterial dnaA protein NB-ARC PF00931.22 KOO33196.1 - 0.0012 18.1 0.1 0.43 9.7 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain DUF815 PF05673.13 KOO33196.1 - 0.0029 16.8 0.0 0.13 11.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_3 PF07726.11 KOO33196.1 - 0.0036 17.2 0.0 2.7 7.9 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 KOO33196.1 - 0.0038 17.0 0.1 0.75 9.5 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase ATPase_2 PF01637.18 KOO33196.1 - 0.0039 17.1 0.3 0.065 13.1 0.0 2.6 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 KOO33196.1 - 0.0049 17.2 0.5 3.9 7.8 0.4 3.0 2 1 1 3 3 2 0 AAA domain AAA_29 PF13555.6 KOO33196.1 - 0.006 16.3 0.0 4.4 7.1 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Cytidylate_kin2 PF13189.6 KOO33196.1 - 0.0071 16.5 0.0 3 7.9 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family Viral_helicase1 PF01443.18 KOO33196.1 - 0.0087 15.8 0.0 0.2 11.4 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 KOO33196.1 - 0.0087 15.8 0.2 1.3 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 KOO33196.1 - 0.01 15.2 0.1 4.4 6.7 0.0 3.0 2 1 1 3 3 3 0 Bacterial TniB protein PduV-EutP PF10662.9 KOO33196.1 - 0.017 14.9 0.0 3.7 7.3 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 KOO33196.1 - 0.024 14.1 0.1 2.5 7.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AFG1_ATPase PF03969.16 KOO33196.1 - 0.062 12.2 0.1 8.7 5.1 0.1 2.2 2 0 0 2 2 2 0 AFG1-like ATPase AAA_11 PF13086.6 KOO33196.1 - 0.071 12.9 0.0 5.6 6.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 KOO33196.1 - 0.074 12.3 0.0 10 5.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 KOO33196.1 - 0.083 12.8 4.3 5.5 6.9 0.0 3.6 3 1 1 4 4 4 0 NTPase ResIII PF04851.15 KOO33196.1 - 0.086 12.8 0.0 14 5.7 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.17 KOO33196.1 - 0.088 11.9 0.0 1.1 8.3 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_23 PF13476.6 KOO33196.1 - 0.11 13.0 0.0 9.1 6.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain CPT PF07931.12 KOO33196.1 - 0.12 12.2 0.0 16 5.3 0.0 2.6 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein APS_kinase PF01583.20 KOO33196.1 - 0.12 12.3 0.1 20 5.1 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase SKI PF01202.22 KOO33196.1 - 0.15 12.2 0.3 4 7.5 0.1 2.3 2 0 0 2 2 2 0 Shikimate kinase SRPRB PF09439.10 KOO33196.1 - 0.16 11.4 0.0 13 5.1 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit DEAD PF00270.29 KOO33196.1 - 0.18 11.6 0.1 87 2.8 0.0 3.6 4 0 0 4 4 3 0 DEAD/DEAH box helicase AAA_21 PF13304.6 KOO33196.1 - 0.21 11.4 0.3 7.1 6.3 0.0 2.9 2 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Exo_endo_phos PF03372.23 KOO33197.1 - 4e-08 33.1 0.0 4e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Hint PF01079.20 KOO33198.1 - 2.7e-16 59.8 0.2 3.1e-16 59.5 0.2 1.0 1 0 0 1 1 1 1 Hint module Intein_splicing PF14890.6 KOO33198.1 - 0.0075 16.2 0.0 0.1 12.5 0.0 2.0 1 1 1 2 2 2 1 Intein splicing domain DUF3482 PF11981.8 KOO33199.1 - 2.9 7.2 7.6 4.3 6.6 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Patatin PF01734.22 KOO33200.1 - 2.2e-20 73.7 0.0 5.9e-20 72.3 0.0 1.7 1 0 0 1 1 1 1 Patatin-like phospholipase DUF3336 PF11815.8 KOO33200.1 - 2.5e-20 72.6 0.0 4.9e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) VPS13 PF16908.5 KOO33201.1 - 3.3e-16 59.8 0.0 5.4e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 KOO33201.1 - 2.6e-07 30.7 0.0 1.3e-06 28.5 0.0 2.1 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 Orthopox_A5L PF06193.11 KOO33201.1 - 0.49 9.8 3.1 1 8.8 3.1 1.4 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like Rod_cone_degen PF15201.6 KOO33202.1 - 0.0079 16.3 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 Progressive rod-cone degeneration CENP-B_dimeris PF09026.10 KOO33203.1 - 0.69 10.3 12.5 0.046 14.1 6.6 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM176 PF14851.6 KOO33203.1 - 0.87 9.2 4.7 0.23 11.1 1.2 1.8 2 0 0 2 2 2 0 FAM176 family Nop14 PF04147.12 KOO33203.1 - 1.5 6.9 8.0 1.9 6.6 8.0 1.0 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 KOO33203.1 - 4.7 6.4 9.0 7.1 5.9 9.0 1.2 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 KOO33203.1 - 5.8 4.9 7.6 7 4.6 7.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 KOO33203.1 - 6.3 6.8 6.3 0.81 9.7 1.6 1.8 2 0 0 2 2 2 0 RXT2-like, N-terminal Bestrophin PF01062.21 KOO33205.1 - 8.2e-29 100.9 0.7 1e-28 100.6 0.7 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel MTTB PF06253.11 KOO33205.1 - 0.067 11.2 0.1 0.1 10.6 0.1 1.2 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) NARP1 PF12569.8 KOO33206.1 - 0.37 9.7 2.7 0.56 9.1 2.7 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 LRR_5 PF13306.6 KOO33208.1 - 2.3e-112 370.3 5.8 1.8e-41 141.1 0.1 3.9 1 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) NB-ARC PF00931.22 KOO33208.1 - 2.2e-21 76.2 0.1 5.3e-21 75.0 0.0 1.5 2 0 0 2 2 2 1 NB-ARC domain CHAT PF12770.7 KOO33208.1 - 1.3e-09 37.9 1.1 2.2e-09 37.2 1.1 1.3 1 0 0 1 1 1 1 CHAT domain AAA_22 PF13401.6 KOO33208.1 - 0.033 14.5 0.0 0.073 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO33208.1 - 0.064 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 NACHT domain TFIIB_C_1 PF18542.1 KOO33208.1 - 0.11 12.6 0.1 6.4 6.9 0.0 2.6 2 0 0 2 2 2 0 Transcription factor IIB C-terminal module 1 A2M PF00207.22 KOO33208.1 - 0.28 11.1 6.2 13 5.7 0.1 5.5 6 1 1 7 7 7 0 Alpha-2-macroglobulin family DUF295 PF03478.18 KOO33208.1 - 0.54 9.9 8.0 24 4.6 0.3 6.3 6 4 3 9 9 8 0 Protein of unknown function (DUF295) LRR_5 PF13306.6 KOO33209.1 - 1e-38 132.2 0.4 2.8e-38 130.8 0.5 1.6 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) A2M PF00207.22 KOO33209.1 - 0.00085 19.1 2.1 3.5 7.5 0.1 3.6 1 1 2 4 4 4 2 Alpha-2-macroglobulin family MitoNEET_N PF10660.9 KOO33209.1 - 0.011 15.8 0.2 8.8 6.4 0.0 3.6 1 1 2 3 3 3 0 Iron-containing outer mitochondrial membrane protein N-terminus Fer2_BFD PF04324.15 KOO33209.1 - 0.016 15.6 0.2 24 5.4 0.0 3.4 3 2 0 3 3 3 0 BFD-like [2Fe-2S] binding domain PIF1 PF05970.14 KOO33210.1 - 2.2e-13 50.2 0.1 3.3e-13 49.5 0.1 1.2 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 KOO33210.1 - 5e-07 29.6 1.2 1.1e-06 28.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain SAP PF02037.27 KOO33210.1 - 2.3e-06 27.2 1.6 6.7e-06 25.7 1.6 1.8 1 0 0 1 1 1 1 SAP domain AAA_5 PF07728.14 KOO33210.1 - 0.0015 18.5 0.0 0.06 13.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 KOO33210.1 - 0.0017 18.7 0.0 0.0038 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 KOO33210.1 - 0.031 14.1 0.1 0.56 10.0 0.0 2.2 2 0 0 2 2 2 0 Helicase AAA_16 PF13191.6 KOO33210.1 - 0.045 14.1 0.0 0.045 14.1 0.0 2.7 2 1 0 2 2 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 KOO33210.1 - 0.079 12.9 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 KOO33210.1 - 0.097 12.9 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOO33210.1 - 0.22 11.0 0.1 0.41 10.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 KOO33210.1 - 0.36 10.2 1.5 0.76 9.1 1.5 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF3280 PF11684.8 KOO33210.1 - 3.7 8.0 5.4 2.7 8.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2380) Apolipoprotein PF01442.18 KOO33210.1 - 6.1 6.7 13.6 0.43 10.4 6.4 2.4 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain Ank_4 PF13637.6 KOO33211.1 - 5.1e-18 65.2 2.5 4.6e-08 33.4 0.5 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO33211.1 - 3.1e-16 59.7 0.1 2.1e-12 47.4 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO33211.1 - 1.2e-11 44.5 0.6 0.0016 18.8 0.1 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO33211.1 - 1.4e-11 44.4 0.7 3.3e-09 36.8 0.3 3.1 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33211.1 - 5.3e-06 26.4 0.0 0.27 11.9 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat FAM221 PF14753.6 KOO33212.1 - 9.2e-20 71.0 23.4 1.6e-19 70.3 23.4 1.3 1 0 0 1 1 1 1 Protein FAM221A/B DnaJ PF00226.31 KOO33212.1 - 1.4e-11 44.4 0.0 2.7e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain TIR_2 PF13676.6 KOO33213.1 - 0.00086 19.9 0.0 0.0018 18.9 0.0 1.5 1 0 0 1 1 1 1 TIR domain DDT PF02791.17 KOO33214.1 - 9.6e-12 45.0 0.6 2.1e-11 43.9 0.6 1.6 1 0 0 1 1 1 1 DDT domain MBD PF01429.19 KOO33214.1 - 0.00015 21.4 0.0 0.00033 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyl-CpG binding domain HMG_box_2 PF09011.10 KOO33214.1 - 0.00023 21.7 5.0 0.59 10.8 0.8 3.8 3 0 0 3 3 3 2 HMG-box domain WHIM1 PF15612.6 KOO33214.1 - 0.0014 18.1 0.0 0.0029 17.1 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 HMG_box PF00505.19 KOO33214.1 - 0.026 14.9 11.4 0.048 14.1 1.1 4.3 3 1 0 3 3 3 0 HMG (high mobility group) box Exonuc_VII_L PF02601.15 KOO33214.1 - 0.2 11.2 1.0 0.57 9.7 0.0 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Pkinase PF00069.25 KOO33215.1 - 3.4e-32 111.8 0.0 5e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33215.1 - 2.6e-31 108.9 0.0 3.6e-31 108.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO33215.1 - 0.00014 21.9 0.3 0.034 14.1 0.0 2.1 1 1 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO33215.1 - 0.0012 18.2 0.0 0.0026 17.1 0.0 1.5 2 0 0 2 2 2 1 Kinase-like TIR_2 PF13676.6 KOO33215.1 - 0.0068 17.0 0.0 0.017 15.8 0.0 1.6 1 0 0 1 1 1 1 TIR domain Kdo PF06293.14 KOO33215.1 - 0.0075 15.6 0.2 0.011 15.0 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO33215.1 - 0.034 12.9 0.0 0.067 12.0 0.0 1.4 1 1 0 1 1 1 0 Fungal protein kinase TFIIE_beta PF02186.15 KOO33215.1 - 0.086 13.1 0.1 1.4 9.2 0.1 2.3 2 0 0 2 2 2 0 TFIIE beta subunit core domain NIF PF03031.18 KOO33216.1 - 5.2e-24 84.8 0.0 1.1e-23 83.7 0.0 1.6 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase YGGT PF02325.17 KOO33217.1 - 1.3e-15 57.6 2.7 2.1e-15 56.9 2.7 1.3 1 0 0 1 1 1 1 YGGT family EF-hand_7 PF13499.6 KOO33219.1 - 1.8e-05 25.1 0.8 0.01 16.3 0.1 1.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO33219.1 - 0.00042 19.7 0.2 0.003 17.0 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO33219.1 - 0.0012 18.6 0.0 0.004 17.0 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO33219.1 - 0.0046 16.4 0.0 0.011 15.2 0.0 1.7 1 0 0 1 1 1 1 EF hand DUF3708 PF12501.8 KOO33219.1 - 0.015 15.1 0.0 0.036 13.8 0.0 1.7 2 0 0 2 2 2 0 Phosphate ATP-binding cassette transporter EF-hand_8 PF13833.6 KOO33219.1 - 0.03 14.1 0.8 0.26 11.2 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain pair SPRY PF00622.28 KOO33220.1 - 2.2e-23 82.7 0.0 3e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 SPRY domain LisH_2 PF16045.5 KOO33220.1 - 0.13 11.3 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 LisH LisH PF08513.11 KOO33220.1 - 0.16 11.9 0.1 0.32 11.0 0.1 1.4 1 0 0 1 1 1 0 LisH Thx PF17070.5 KOO33222.1 - 0.38 10.9 7.0 7.6 6.8 0.7 2.6 2 0 0 2 2 2 0 30S ribosomal protein Thx Ank_2 PF12796.7 KOO33223.1 - 3.2e-59 197.5 4.3 3.9e-19 69.0 0.6 4.3 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 KOO33223.1 - 5e-36 121.6 12.9 6.3e-07 29.6 0.3 7.4 7 0 0 7 7 7 7 Ankyrin repeat Ank_4 PF13637.6 KOO33223.1 - 8e-34 115.6 1.3 3.5e-07 30.6 0.0 5.5 3 2 1 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO33223.1 - 2.1e-33 114.0 7.6 1.9e-05 24.8 0.1 7.2 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33223.1 - 2.6e-32 107.2 1.9 0.00023 21.3 0.1 7.5 7 0 0 7 7 7 7 Ankyrin repeat TRAM_LAG1_CLN8 PF03798.16 KOO33224.1 - 1.6e-11 44.4 14.6 1.8e-11 44.2 14.6 1.0 1 0 0 1 1 1 1 TLC domain CLP_protease PF00574.23 KOO33225.1 - 1.3e-75 253.3 0.0 1.5e-75 253.1 0.0 1.0 1 0 0 1 1 1 1 Clp protease SwrA PF17423.2 KOO33225.1 - 0.19 11.7 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Swarming motility protein DNA_ligase_A_M PF01068.21 KOO33227.1 - 1.8e-60 204.1 0.0 3e-60 203.4 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KOO33227.1 - 3.1e-41 141.6 0.1 5.3e-41 140.8 0.1 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 KOO33227.1 - 8.6e-25 87.2 0.0 2.1e-24 86.0 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.6 KOO33227.1 - 0.023 14.7 0.7 4.9 7.3 0.0 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain PDZ_6 PF17820.1 KOO33228.1 - 8.2e-11 41.6 3.5 7.8e-05 22.4 0.1 2.8 2 0 0 2 2 2 2 PDZ domain C2 PF00168.30 KOO33228.1 - 3.5e-08 33.7 0.0 5.9e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain PDZ PF00595.24 KOO33228.1 - 5.9e-08 33.0 1.0 0.0015 18.8 0.1 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KOO33228.1 - 8.5e-06 26.0 0.4 0.028 14.7 0.0 2.4 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 KOO33228.1 - 6.2e-05 22.9 0.7 0.0017 18.3 0.0 2.3 2 0 0 2 2 2 1 Tricorn protease PDZ domain PIH1_CS PF18201.1 KOO33230.1 - 3.7e-12 46.5 0.0 1.5e-11 44.6 0.0 1.8 1 1 1 2 2 2 1 PIH1 CS-like domain ArsA_HSP20 PF17886.1 KOO33230.1 - 3e-06 26.7 0.2 4.1e-05 23.0 0.1 2.1 2 0 0 2 2 2 1 HSP20-like domain found in ArsA CS PF04969.16 KOO33230.1 - 3.2e-05 24.9 0.0 0.015 16.3 0.0 2.1 1 1 1 2 2 2 2 CS domain 2OG-FeII_Oxy_2 PF13532.6 KOO33231.1 - 0.018 15.3 0.0 0.028 14.6 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily E1_dh PF00676.20 KOO33232.1 - 1.9e-102 342.3 0.1 2.4e-102 341.9 0.1 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 KOO33232.1 - 0.00035 19.9 0.1 0.0005 19.4 0.1 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E3_binding PF02817.17 KOO33232.1 - 0.00047 20.4 0.0 0.0012 19.1 0.0 1.8 1 0 0 1 1 1 1 e3 binding domain Transketolase_N PF00456.21 KOO33232.1 - 0.51 9.2 2.2 0.69 8.8 0.0 2.3 4 0 0 4 4 4 0 Transketolase, thiamine diphosphate binding domain Pkinase PF00069.25 KOO33233.1 - 1.5e-59 201.5 0.0 1.9e-59 201.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33233.1 - 3.3e-41 141.3 0.0 4.1e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO33233.1 - 1.7e-05 24.3 0.1 2.7e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO33233.1 - 0.00023 20.0 0.0 0.00033 19.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO33233.1 - 0.00099 18.5 0.0 0.0063 15.9 0.0 2.2 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 KOO33233.1 - 0.046 13.6 0.0 0.083 12.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ank_4 PF13637.6 KOO33234.1 - 0.0023 18.5 0.2 0.33 11.6 0.0 3.2 3 1 0 3 3 3 2 Ankyrin repeats (many copies) DUF1517 PF07466.11 KOO33235.1 - 0.12 12.5 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) CBM_1 PF00734.18 KOO33238.1 - 2e-23 82.0 65.0 3.6e-08 33.2 7.6 5.9 6 1 0 6 6 6 4 Fungal cellulose binding domain FtsZ_C PF12327.8 KOO33240.1 - 0.1 12.9 2.8 0.17 12.2 2.7 1.5 1 1 0 1 1 1 0 FtsZ family, C-terminal domain Pkinase_Tyr PF07714.17 KOO33241.1 - 4.7e-23 81.8 0.1 7.1e-23 81.2 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO33241.1 - 2.2e-20 73.1 0.0 3.5e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 KOO33241.1 - 1.1e-06 29.0 0.1 0.00032 21.2 0.1 2.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO33241.1 - 1.4e-06 28.8 0.1 8.1e-06 26.3 0.0 2.3 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) tRNA_U5-meth_tr PF05958.11 KOO33241.1 - 6.9e-05 22.0 0.0 0.00014 20.9 0.0 1.5 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Ank_3 PF13606.6 KOO33241.1 - 0.0018 18.6 0.0 3.7 8.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KOO33241.1 - 0.0066 16.8 0.2 0.038 14.3 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) FA_desaturase PF00487.24 KOO33241.1 - 0.16 11.8 2.0 0.29 10.9 2.0 1.3 1 0 0 1 1 1 0 Fatty acid desaturase Ank_2 PF12796.7 KOO33244.1 - 5.9e-07 30.0 0.0 1.9e-06 28.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33244.1 - 4.8e-06 27.0 0.0 1.3e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO33244.1 - 9.6e-05 22.7 0.0 0.0006 20.1 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 KOO33244.1 - 0.00017 21.8 0.0 0.0017 18.6 0.0 2.4 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33244.1 - 0.00086 19.6 0.0 0.0051 17.2 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat IQ PF00612.27 KOO33244.1 - 0.0014 18.3 2.3 0.0042 16.7 2.3 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif RRM_1 PF00076.22 KOO33244.1 - 0.16 11.8 0.0 0.41 10.5 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_1 PF00036.32 KOO33245.1 - 1.4e-19 68.1 2.9 0.00017 20.9 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO33245.1 - 1.6e-18 65.0 3.6 8.6e-05 22.2 0.1 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KOO33245.1 - 4.9e-17 60.6 8.6 2.3e-05 23.6 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO33245.1 - 1.5e-16 60.6 0.8 6.9e-09 36.0 0.1 3.3 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO33245.1 - 4e-16 58.6 1.4 1.8e-06 27.7 0.1 3.7 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO33245.1 - 0.042 14.2 0.0 0.61 10.4 0.0 2.6 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO33245.1 - 0.14 12.5 0.0 2.1 8.7 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain APOBEC_N PF08210.11 KOO33246.1 - 2.5e-13 50.3 0.0 4e-12 46.4 0.0 2.2 1 1 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC4 PF18775.1 KOO33246.1 - 0.00038 20.5 0.1 0.0042 17.2 0.1 2.6 1 1 0 1 1 1 1 APOBEC4 SNAD4 PF18750.1 KOO33246.1 - 0.0044 17.1 0.0 3.2 7.9 0.0 4.0 3 1 0 3 3 3 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 KOO33246.1 - 0.0078 16.3 0.0 0.23 11.5 0.0 3.0 3 1 0 3 3 3 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 KOO33246.1 - 0.048 13.7 0.0 1.8 8.6 0.0 2.7 3 0 0 3 3 3 0 APOBEC2 APOBEC_C PF05240.14 KOO33246.1 - 0.11 12.5 0.0 0.33 11.0 0.0 1.8 1 0 0 1 1 1 0 APOBEC-like C-terminal domain APOBEC4_like PF18774.1 KOO33246.1 - 0.14 12.1 0.0 0.91 9.5 0.0 2.4 2 1 0 2 2 2 0 APOBEC4-like -AID/APOBEC-deaminase ABM PF03992.16 KOO33246.1 - 0.25 11.5 0.2 0.25 11.5 0.2 2.8 2 1 1 3 3 3 0 Antibiotic biosynthesis monooxygenase zf-CCCH PF00642.24 KOO33247.1 - 2.9e-23 81.2 18.0 7.6e-09 35.3 0.3 3.4 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOO33247.1 - 2.6e-14 52.7 18.6 0.00011 22.2 5.8 3.6 3 0 0 3 3 3 3 Zinc finger domain zf-CCCH_4 PF18044.1 KOO33247.1 - 0.00033 20.4 14.5 0.064 13.1 0.4 3.5 3 0 0 3 3 3 3 CCCH-type zinc finger Torus PF16131.5 KOO33247.1 - 0.0013 19.4 11.7 0.52 11.0 0.7 3.8 1 1 2 3 3 3 3 Torus domain zf-CCCH_2 PF14608.6 KOO33247.1 - 0.0093 16.4 11.9 0.9 10.1 3.0 3.4 3 0 0 3 3 3 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 KOO33247.1 - 0.67 10.2 7.4 8.3 6.7 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger containing family Ion_trans PF00520.31 KOO33250.1 - 2e-22 79.6 17.0 2.9e-22 79.1 17.0 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO33250.1 - 1.6e-11 44.0 6.2 1.6e-11 44.0 6.2 2.4 2 1 0 2 2 2 1 Ion channel cNMP_binding PF00027.29 KOO33250.1 - 2.6e-10 40.2 0.0 5.6e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain YkyB PF14177.6 KOO33250.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 YkyB-like protein CENP-T_C PF15511.6 KOO33252.1 - 2.7e-05 24.2 0.2 3.8e-05 23.8 0.2 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KOO33252.1 - 0.006 16.9 0.1 0.0091 16.4 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 KOO33252.1 - 0.023 15.0 0.2 0.036 14.4 0.2 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 KOO33252.1 - 0.096 12.7 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Bromodomain associated CBFD_NFYB_HMF PF00808.23 KOO33252.1 - 0.21 11.9 0.3 0.35 11.2 0.3 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2841 PF11001.8 KOO33253.1 - 0.065 13.3 0.3 1 9.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2841) Bromodomain PF00439.25 KOO33254.1 - 3.7e-14 52.5 0.0 8.5e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 KOO33254.1 - 3.9e-08 33.0 10.6 9.5e-08 31.8 10.6 1.7 1 0 0 1 1 1 1 PHD-finger Acetyltransf_7 PF13508.7 KOO33254.1 - 1.6e-07 31.6 0.0 3.6e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO33254.1 - 1.9e-07 31.0 0.3 8.8e-07 28.9 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO33254.1 - 4.6e-07 30.1 0.0 9.4e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family PanZ PF12568.8 KOO33254.1 - 0.038 13.7 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ DUF1336 PF07059.12 KOO33256.1 - 9.7e-21 74.9 0.0 1.1e-20 74.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) Exo_endo_phos PF03372.23 KOO33257.1 - 0.0011 18.5 0.1 0.0017 17.9 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ku_PK_bind PF08785.11 KOO33259.1 - 0.089 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Ku C terminal domain like IF3_C PF00707.22 KOO33260.1 - 4.4e-29 100.3 0.3 6.5e-29 99.7 0.3 1.2 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 KOO33260.1 - 2.8e-20 72.3 0.2 5.8e-20 71.3 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain mIF3 PF14877.6 KOO33260.1 - 0.0043 16.7 0.8 0.0064 16.2 0.8 1.2 1 0 0 1 1 1 1 Mitochondrial translation initiation factor PhdYeFM_antitox PF02604.19 KOO33260.1 - 0.069 13.0 0.3 0.12 12.2 0.3 1.3 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system PSP1 PF04468.12 KOO33260.1 - 0.094 13.0 0.4 0.15 12.3 0.4 1.3 1 0 0 1 1 1 0 PSP1 C-terminal conserved region Exo_endo_phos PF03372.23 KOO33261.1 - 0.0011 18.5 0.1 0.0017 17.9 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4203 PF13886.6 KOO33262.1 - 1.1e-09 38.3 25.1 4.4e-06 26.5 22.9 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4203) DDDD PF10161.9 KOO33262.1 - 0.096 12.5 0.1 0.55 10.0 0.1 2.3 1 0 0 1 1 1 0 Putative mitochondrial precursor protein DUF2480 PF10652.9 KOO33262.1 - 0.11 12.3 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2480) IF3_C PF00707.22 KOO33263.1 - 4.4e-29 100.3 0.3 6.5e-29 99.7 0.3 1.2 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 KOO33263.1 - 2.8e-20 72.3 0.2 5.8e-20 71.3 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain mIF3 PF14877.6 KOO33263.1 - 0.0043 16.7 0.8 0.0064 16.2 0.8 1.2 1 0 0 1 1 1 1 Mitochondrial translation initiation factor PhdYeFM_antitox PF02604.19 KOO33263.1 - 0.069 13.0 0.3 0.12 12.2 0.3 1.3 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system PSP1 PF04468.12 KOO33263.1 - 0.094 13.0 0.4 0.15 12.3 0.4 1.3 1 0 0 1 1 1 0 PSP1 C-terminal conserved region PHO4 PF01384.20 KOO33264.1 - 2.3e-48 165.0 0.6 2.4e-48 164.9 0.6 1.1 1 0 0 1 1 1 1 Phosphate transporter family Ank_5 PF13857.6 KOO33265.1 - 0.0015 18.8 0.0 0.003 17.8 0.0 1.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) TIG PF01833.24 KOO33266.1 - 3.2e-54 181.0 0.9 5.3e-06 26.4 0.0 15.2 15 2 0 15 15 15 11 IPT/TIG domain TIG_plexin PF17960.1 KOO33266.1 - 6.9e-14 51.6 0.0 0.12 12.4 0.0 10.7 15 1 1 16 16 16 3 TIG domain Anth_Ig PF05587.13 KOO33266.1 - 0.068 13.5 0.0 43 4.5 0.0 4.0 5 0 0 5 5 5 0 Anthrax receptor extracellular domain Pkinase PF00069.25 KOO33267.1 - 2e-63 214.2 0.0 3.7e-63 213.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33267.1 - 4e-42 144.3 0.0 7.2e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO33267.1 - 0.00017 20.6 0.0 0.00039 19.5 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Vps51 PF08700.11 KOO33267.1 - 0.00037 20.5 0.7 0.0093 16.0 0.0 3.0 3 0 0 3 3 3 1 Vps51/Vps67 Sec5 PF15469.6 KOO33267.1 - 0.00046 20.1 0.5 0.00046 20.1 0.5 1.8 2 0 0 2 2 2 1 Exocyst complex component Sec5 Pkinase_fungal PF17667.1 KOO33267.1 - 0.0011 17.8 0.0 0.0021 16.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO33267.1 - 0.012 15.0 0.0 0.42 9.9 0.0 2.5 2 0 0 2 2 2 0 Kinase-like Seadorna_VP7 PF07387.11 KOO33267.1 - 0.042 12.9 0.1 0.076 12.1 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 KOO33267.1 - 0.24 11.3 2.3 0.74 9.7 0.0 2.9 3 1 1 4 4 4 0 Phosphotransferase enzyme family LMBR1 PF04791.16 KOO33268.1 - 2.5e-18 66.3 1.3 3.3e-18 65.9 1.3 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein CitMHS PF03600.16 KOO33269.1 - 2.7e-27 95.8 67.3 1.6e-24 86.7 39.9 2.3 2 1 1 3 3 3 2 Citrate transporter TrkA_C PF02080.21 KOO33269.1 - 0.00043 20.0 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 2 TrkA-C domain Kinesin PF00225.23 KOO33270.1 - 6.9e-07 28.5 0.7 4e-06 26.0 0.0 2.5 3 0 0 3 3 3 1 Kinesin motor domain DUF3287 PF11690.8 KOO33270.1 - 7.6 6.3 7.0 0.74 9.5 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3287) DnaJ PF00226.31 KOO33271.1 - 7.8e-27 93.2 1.9 1.1e-26 92.7 1.9 1.3 1 0 0 1 1 1 1 DnaJ domain PDZ PF00595.24 KOO33271.1 - 4.4e-16 59.0 2.9 5.4e-10 39.5 0.2 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KOO33271.1 - 3.8e-15 55.5 1.2 1.9e-07 30.8 0.2 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KOO33271.1 - 1.4e-09 38.1 1.1 7.7e-05 22.9 0.1 2.4 2 1 0 2 2 2 2 PDZ domain RPT PF13446.6 KOO33271.1 - 0.0028 17.5 0.3 0.0059 16.5 0.0 1.6 2 0 0 2 2 2 1 A repeated domain in UCH-protein Rad60-SLD PF11976.8 KOO33272.1 - 7e-25 86.7 0.1 8.4e-25 86.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOO33272.1 - 1.7e-14 53.3 0.0 2e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family DUF917 PF06032.12 KOO33272.1 - 0.063 12.1 0.0 0.074 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF917) Sushi PF00084.20 KOO33272.1 - 0.1 13.2 0.0 0.17 12.5 0.0 1.3 1 0 0 1 1 1 0 Sushi repeat (SCR repeat) DUF3045 PF11243.8 KOO33272.1 - 0.16 12.2 0.0 0.18 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3045) Glucodextran_B PF09136.10 KOO33273.1 - 0.09 13.2 0.3 0.09 13.2 0.3 1.9 2 0 0 2 2 2 0 Glucodextranase, domain B HECT PF00632.25 KOO33274.1 - 3.8e-27 95.6 0.0 5.4e-27 95.1 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RRM_1 PF00076.22 KOO33274.1 - 7.4e-08 32.1 0.0 1.5e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DLH PF01738.18 KOO33275.1 - 1.9e-17 63.5 0.0 3.2e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Gly_transf_sug PF04488.15 KOO33275.1 - 9.2e-11 42.2 0.0 1.6e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 KOO33275.1 - 0.0078 15.6 0.1 0.97 8.7 0.0 2.1 2 0 0 2 2 2 2 TcdA/TcdB catalytic glycosyltransferase domain Hydrolase_4 PF12146.8 KOO33275.1 - 0.16 11.2 0.0 0.85 8.8 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 SAM_1 PF00536.30 KOO33278.1 - 4e-16 59.2 0.5 4.4e-16 59.1 0.5 1.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO33278.1 - 6.6e-12 45.4 0.2 7.3e-12 45.2 0.2 1.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KOO33278.1 - 0.0014 18.6 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain DUF5340 PF17275.2 KOO33278.1 - 0.044 13.9 0.3 0.062 13.4 0.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5340) NatB_MDM20 PF09797.9 KOO33279.1 - 2.1e-33 115.8 0.0 2.8e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 KOO33279.1 - 0.0064 17.0 37.4 0.1 13.1 0.4 5.5 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO33279.1 - 0.7 10.4 3.2 33 5.2 0.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO33279.1 - 1.5 9.8 0.0 1.4 9.9 1.1 8.2 3 3 6 10 10 10 0 Tetratricopeptide repeat NARP1 PF12569.8 KOO33279.1 - 1.7 7.4 7.5 0.055 12.4 0.9 1.8 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 KOO33279.1 - 3.6 7.8 21.6 0.12 12.5 4.8 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat PDZ PF00595.24 KOO33281.1 - 3e-05 24.3 0.0 6.8e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DNA_ligase_A_M PF01068.21 KOO33282.1 - 3.4e-16 59.5 0.0 6.2e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KOO33282.1 - 4.8e-15 56.3 0.0 1.6e-14 54.6 0.0 1.9 3 0 0 3 3 3 1 DNA ligase N terminus Thiolase_N PF00108.23 KOO33283.1 - 4.7e-72 242.5 0.0 6.8e-72 241.9 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOO33283.1 - 4.6e-43 145.8 0.0 9.4e-43 144.8 0.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KOO33283.1 - 4.8e-07 29.6 0.1 1.2e-06 28.3 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.11 KOO33283.1 - 0.099 11.3 0.0 0.16 10.6 0.0 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) Chromo PF00385.24 KOO33284.1 - 6.8e-07 29.1 0.2 1.7e-06 27.8 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Baculo_VP91_N PF08475.10 KOO33285.1 - 0.18 11.4 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal HAD_SAK_2 PF18143.1 KOO33287.1 - 6.3e-30 104.3 0.0 1.1e-29 103.6 0.0 1.4 1 0 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins HRCT1 PF15758.5 KOO33287.1 - 0.078 13.9 0.1 19 6.3 0.0 2.2 2 0 0 2 2 2 0 Histidine-rich carboxyl terminus protein 1 GCIP PF13324.6 KOO33287.1 - 0.31 10.6 3.6 0.36 10.4 2.8 1.4 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting Lactamase_B_2 PF12706.7 KOO33288.1 - 1e-10 41.5 0.3 0.00012 21.6 0.1 2.9 2 1 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KOO33288.1 - 5.4e-05 23.3 0.0 9.3e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 KOO33288.1 - 0.17 11.6 0.0 0.4 10.4 0.0 1.6 1 0 0 1 1 1 0 tRNase Z endonuclease YrhK PF14145.6 KOO33290.1 - 0.0016 18.3 36.7 0.33 10.8 3.6 6.1 5 1 0 5 5 5 4 YrhK-like protein DUF1003 PF06210.11 KOO33290.1 - 0.78 9.9 0.1 0.78 9.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) Nucleotid_trans PF03407.16 KOO33291.1 - 9.3e-13 48.6 0.0 2.9e-06 27.4 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-diphospho-sugar transferase GDPD PF03009.17 KOO33292.1 - 0.0032 17.3 0.0 0.0046 16.7 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family EamA PF00892.20 KOO33294.1 - 8e-05 22.8 14.9 8e-05 22.8 14.9 2.3 2 1 1 3 3 3 2 EamA-like transporter family DUF423 PF04241.15 KOO33294.1 - 0.085 13.1 5.3 4.2 7.6 0.7 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF423) TPR_2 PF07719.17 KOO33296.1 - 4.6e-29 98.2 27.4 0.00064 19.6 0.0 11.9 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33296.1 - 2.6e-28 96.6 1.9 0.00092 18.9 0.0 10.8 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOO33296.1 - 1.1e-17 62.7 0.2 0.0025 17.9 0.0 8.1 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO33296.1 - 2.1e-17 62.5 4.8 0.0025 17.5 0.0 9.3 7 2 3 10 10 10 3 TPR repeat TPR_16 PF13432.6 KOO33296.1 - 9.6e-16 58.2 56.2 0.00019 22.0 0.4 8.2 5 2 4 9 9 9 7 Tetratricopeptide repeat TPR_9 PF13371.6 KOO33296.1 - 1.8e-13 50.4 42.8 0.00011 22.3 0.8 7.5 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOO33296.1 - 3.3e-13 49.7 38.3 0.02 15.2 0.1 8.5 5 2 4 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO33296.1 - 1.8e-11 44.4 37.4 0.014 15.9 1.8 6.8 5 1 2 7 7 7 6 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO33296.1 - 4.7e-07 29.8 5.2 0.22 11.6 0.0 4.0 3 1 1 4 4 3 3 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 KOO33296.1 - 4.6e-06 27.0 54.4 0.29 12.1 0.8 10.5 5 3 6 12 12 10 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOO33296.1 - 4.9e-06 26.6 8.9 0.12 12.8 0.0 7.5 10 1 0 10 10 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO33296.1 - 1.9e-05 24.4 14.1 1.3 9.2 0.1 8.3 9 1 1 10 10 9 2 Tetratricopeptide repeat BASP1 PF05466.12 KOO33296.1 - 0.0042 17.2 1.8 0.0073 16.4 1.8 1.3 1 0 0 1 1 1 1 Brain acid soluble protein 1 (BASP1 protein) SUIM_assoc PF16619.5 KOO33296.1 - 0.011 15.8 2.3 0.022 14.8 2.3 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Sin_N PF04801.13 KOO33296.1 - 0.057 12.6 1.5 0.081 12.1 1.5 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Streptin-Immun PF11083.8 KOO33296.1 - 0.1 13.0 1.4 5 7.6 0.0 2.9 3 0 0 3 3 3 0 Lantibiotic streptin immunity protein DUF3275 PF11679.8 KOO33296.1 - 0.1 12.5 1.9 0.18 11.8 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Coatomer_E PF04733.14 KOO33296.1 - 0.44 9.9 7.0 8.5 5.7 1.9 3.7 3 1 1 4 4 4 0 Coatomer epsilon subunit SHNi-TPR PF10516.9 KOO33296.1 - 0.45 10.0 6.9 2.9 7.4 0.0 4.7 5 0 0 5 5 5 0 SHNi-TPR TPR_10 PF13374.6 KOO33296.1 - 1.8 8.6 24.4 14 5.7 0.2 8.1 8 1 1 9 9 9 0 Tetratricopeptide repeat EF-hand_7 PF13499.6 KOO33298.1 - 1.1e-13 51.4 0.3 7.8e-09 35.9 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO33298.1 - 2.1e-13 48.8 0.8 4.6e-05 22.7 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KOO33298.1 - 9.7e-11 40.7 1.3 0.00015 21.1 0.0 2.9 3 0 0 3 3 3 2 EF hand C2 PF00168.30 KOO33298.1 - 3.9e-10 40.0 0.0 1.1e-09 38.5 0.0 1.8 1 0 0 1 1 1 1 C2 domain EF-hand_6 PF13405.6 KOO33298.1 - 7.6e-09 34.8 1.1 0.0012 18.6 0.0 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KOO33298.1 - 1.9e-06 27.6 0.1 0.00024 20.9 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO33298.1 - 0.0031 17.8 0.0 0.0077 16.5 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO33298.1 - 0.074 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Enolase_C PF00113.22 KOO33298.1 - 0.13 11.5 3.2 0.35 10.1 0.8 2.5 2 1 1 3 3 3 0 Enolase, C-terminal TIM barrel domain Helicase_C PF00271.31 KOO33299.1 - 7.5e-07 29.5 0.0 1.2e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain 2CSK_N PF08521.10 KOO33299.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Two-component sensor kinase N-terminal Ank_2 PF12796.7 KOO33300.1 - 9.7e-13 48.5 0.0 4.9e-12 46.3 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Sel1 PF08238.12 KOO33300.1 - 2.8e-10 40.5 14.5 2.1e-07 31.4 1.6 4.8 5 0 0 5 5 5 2 Sel1 repeat Ank_4 PF13637.6 KOO33300.1 - 4.3e-10 39.9 0.4 3.2e-06 27.6 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) U-box PF04564.15 KOO33300.1 - 7.2e-10 38.9 0.0 1.4e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain Ank_5 PF13857.6 KOO33300.1 - 9.2e-09 35.4 0.4 0.0017 18.6 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33300.1 - 9.4e-07 28.7 0.9 0.79 10.5 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KOO33300.1 - 1.7e-06 28.2 2.4 0.074 13.5 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat zf-Nse PF11789.8 KOO33300.1 - 0.00085 19.1 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO33300.1 - 0.008 16.3 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein YtxH PF12732.7 KOO33300.1 - 0.11 13.0 0.0 0.37 11.4 0.0 1.9 1 0 0 1 1 1 0 YtxH-like protein DUF2396 PF09654.10 KOO33300.1 - 0.4 10.8 3.9 11 6.1 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2396) VPS13 PF16908.5 KOO33302.1 - 1.4e-07 31.5 0.0 2.1e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 KOO33302.1 - 2.8e-06 27.4 0.0 4.5e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 Pkinase PF00069.25 KOO33304.1 - 7e-29 101.0 0.0 1e-28 100.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33304.1 - 3.3e-23 82.3 0.0 7.2e-23 81.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO33304.1 - 0.0084 15.5 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO33304.1 - 0.016 14.0 0.0 0.036 12.9 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Pkinase PF00069.25 KOO33305.1 - 2.8e-44 151.5 0.0 3.8e-44 151.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33305.1 - 4.3e-38 131.1 0.0 7.7e-38 130.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO33305.1 - 0.00015 20.7 0.0 0.00023 20.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO33305.1 - 0.0017 17.7 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO33305.1 - 0.045 13.1 0.0 0.078 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO33305.1 - 0.054 13.4 0.1 0.35 10.8 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Tubulin PF00091.25 KOO33306.1 - 1.6e-42 146.0 0.0 1.8e-42 145.8 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Pro_isomerase PF00160.21 KOO33307.1 - 1.7e-23 83.6 0.0 2.2e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Guanylate_kin PF00625.21 KOO33308.1 - 9.1e-43 146.1 0.0 1.3e-42 145.6 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase HEAT PF02985.22 KOO33309.1 - 0.0023 18.0 0.0 0.004 17.3 0.0 1.4 1 0 0 1 1 1 1 HEAT repeat HEAT_2 PF13646.6 KOO33309.1 - 0.0065 16.8 0.0 0.009 16.4 0.0 1.2 1 0 0 1 1 1 1 HEAT repeats WASH-7_mid PF14744.6 KOO33310.1 - 3.6e-82 276.2 0.0 1.6e-81 274.1 0.0 2.0 1 1 0 1 1 1 1 WASH complex subunit 7 WASH-7_N PF14745.6 KOO33310.1 - 6.2e-65 219.8 0.0 1.5e-62 211.9 0.0 2.1 1 1 1 2 2 2 2 WASH complex subunit 7, N-terminal WASH-7_C PF14746.6 KOO33310.1 - 2.1e-50 170.9 0.1 3.9e-50 169.9 0.1 1.4 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal zf-C2H2 PF00096.26 KOO33311.1 - 1.1e-27 94.9 54.3 7.4e-05 23.0 2.1 7.4 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO33311.1 - 6.7e-26 89.5 50.6 9.8e-07 28.9 0.5 7.9 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO33311.1 - 4.1e-14 52.0 45.5 0.014 16.2 1.2 7.7 7 0 0 7 7 7 6 C2H2-type zinc finger CHORD PF04968.12 KOO33311.1 - 0.00028 21.5 40.9 0.52 11.1 0.9 6.8 1 1 5 6 6 6 5 CHORD MORN_2 PF07661.13 KOO33311.1 - 0.002 18.2 0.2 5.5 7.5 0.0 4.3 5 0 0 5 5 5 1 MORN repeat variant zf-C2H2_8 PF15909.5 KOO33311.1 - 0.055 13.8 18.1 1.1 9.6 3.6 3.6 1 1 1 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 KOO33311.1 - 0.068 13.2 0.2 0.068 13.2 0.2 7.1 7 0 0 7 7 7 0 C2H2-type zinc finger Choline_kinase PF01633.20 KOO33311.1 - 0.13 11.9 0.0 15 5.1 0.0 2.8 1 1 3 4 4 4 0 Choline/ethanolamine kinase FANCL_C PF11793.8 KOO33311.1 - 3.8 7.8 30.4 0.3 11.3 1.2 7.5 2 2 6 8 8 8 0 FANCL C-terminal domain DnaJ PF00226.31 KOO33312.1 - 4e-21 74.9 0.1 6.7e-21 74.2 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain FATC PF02260.20 KOO33313.1 - 7.2e-06 25.7 0.1 1.5e-05 24.7 0.1 1.6 1 0 0 1 1 1 1 FATC domain Complex1_LYR PF05347.15 KOO33314.1 - 3.1e-15 56.0 0.1 4.3e-15 55.5 0.1 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOO33314.1 - 1.3e-05 25.8 0.3 1.5e-05 25.6 0.3 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 KOO33314.1 - 0.00037 21.0 0.1 0.00038 21.0 0.1 1.3 1 1 0 1 1 1 1 Complex1_LYR-like SKA2 PF16740.5 KOO33314.1 - 0.045 13.5 0.1 0.11 12.3 0.1 1.5 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Hemerythrin PF01814.23 KOO33315.1 - 0.18 12.4 2.4 0.67 10.6 0.2 2.8 2 1 2 4 4 4 0 Hemerythrin HHE cation binding domain IQ PF00612.27 KOO33318.1 - 0.025 14.4 5.9 2.6 8.1 0.2 4.2 3 0 0 3 3 3 0 IQ calmodulin-binding motif EF-hand_8 PF13833.6 KOO33319.1 - 1.8e-11 43.7 0.4 9.9e-08 31.7 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO33319.1 - 2e-10 39.4 0.1 3.8e-06 26.1 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO33319.1 - 4e-10 38.8 0.2 7.9e-06 25.4 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO33319.1 - 1.8e-09 37.9 0.3 3.4e-09 37.0 0.3 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO33319.1 - 2e-09 36.5 0.7 5e-07 28.9 0.3 2.4 2 0 0 2 2 2 2 EF hand WW PF00397.26 KOO33319.1 - 6.2e-05 23.0 4.1 7.9e-05 22.7 0.3 2.4 2 0 0 2 2 2 1 WW domain EF-hand_11 PF08976.11 KOO33319.1 - 0.0042 17.9 0.0 0.0082 17.0 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain zf-C3HC4_2 PF13923.6 KOO33320.1 - 4.8e-09 35.9 9.0 4.8e-09 35.9 9.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO33320.1 - 1.4e-08 34.5 10.7 1.4e-08 34.5 10.7 2.2 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO33320.1 - 1.1e-06 28.4 7.8 1.1e-06 28.4 7.8 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO33320.1 - 5.9e-06 26.5 9.8 5.9e-06 26.5 9.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RanBP PF00641.18 KOO33320.1 - 6.1e-06 25.5 7.7 6.1e-06 25.5 7.7 2.4 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others zf-RING_UBOX PF13445.6 KOO33320.1 - 3.7e-05 23.7 9.6 3.7e-05 23.7 9.6 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KOO33320.1 - 8.7e-05 22.6 9.6 8.7e-05 22.6 9.6 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KOO33320.1 - 0.00045 20.1 8.5 0.00045 20.1 8.5 2.4 2 1 0 2 2 1 1 zinc-RING finger domain zf-Nse PF11789.8 KOO33320.1 - 0.006 16.4 5.9 0.006 16.4 5.9 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 KOO33320.1 - 0.0082 16.0 4.3 0.0082 16.0 4.3 1.7 2 0 0 2 2 1 1 zf-RING of BARD1-type protein Ribosomal_L37e PF01907.19 KOO33320.1 - 0.054 13.7 2.2 0.17 12.0 2.2 1.8 1 0 0 1 1 1 0 Ribosomal protein L37e DZR PF12773.7 KOO33320.1 - 0.083 12.9 11.1 1.9 8.6 0.7 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-RING_10 PF16685.5 KOO33320.1 - 0.42 10.8 10.9 0.055 13.6 4.1 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-4CXXC_R1 PF10497.9 KOO33320.1 - 0.85 9.9 7.4 2.6 8.3 0.6 2.7 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-MIZ PF02891.20 KOO33320.1 - 1.1 9.0 13.7 1.6 8.5 0.5 2.4 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-Sec23_Sec24 PF04810.15 KOO33320.1 - 3.2 7.9 5.4 11 6.2 0.5 3.1 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger Prok-RING_4 PF14447.6 KOO33320.1 - 4.8 7.1 14.0 40 4.2 0.3 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 KOO33320.1 - 8.7 6.7 15.2 0.72 10.2 7.6 2.8 2 1 1 3 3 3 0 RING-H2 zinc finger domain zf-C3HC4_5 PF17121.5 KOO33320.1 - 9 6.3 12.0 0.93 9.4 6.2 2.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Inhibitor_G39P PF11417.8 KOO33321.1 - 0.17 12.5 0.5 1.4 9.5 0.0 2.5 3 0 0 3 3 3 0 Loader and inhibitor of phage G40P FliD_C PF07195.12 KOO33321.1 - 0.69 9.3 5.6 2.5 7.5 5.6 2.0 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus NTPase_I-T PF01931.18 KOO33322.1 - 5.3e-20 71.8 0.0 6.4e-20 71.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 IglC PF11550.8 KOO33323.1 - 0.21 11.1 0.8 0.36 10.3 0.8 1.3 1 0 0 1 1 1 0 Intracellular growth locus C protein Amidohydro_1 PF01979.20 KOO33324.1 - 4e-56 190.8 0.0 6.7e-55 186.8 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KOO33324.1 - 2.7e-09 37.0 0.1 6.1e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family GIDA_assoc PF13932.6 KOO33325.1 - 0.0085 16.3 1.1 0.012 15.8 1.1 1.2 1 0 0 1 1 1 1 GidA associated domain DUF4200 PF13863.6 KOO33325.1 - 0.032 14.6 2.2 0.051 14.0 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) PBP_N PF17093.5 KOO33325.1 - 0.057 13.7 3.2 0.086 13.1 3.2 1.3 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus FeS PF04060.13 KOO33325.1 - 0.17 11.6 0.2 0.33 10.7 0.2 1.5 1 0 0 1 1 1 0 Putative Fe-S cluster DUF5024 PF16427.5 KOO33327.1 - 0.29 11.5 2.0 28 5.1 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5024) GFO_IDH_MocA PF01408.22 KOO33328.1 - 4.5e-10 40.4 0.1 2.8e-09 37.8 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold DUF5064 PF16703.5 KOO33328.1 - 0.18 12.3 0.0 0.42 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5064) EF-hand_1 PF00036.32 KOO33329.1 - 2.5e-22 76.7 0.1 0.00016 21.0 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO33329.1 - 9.8e-19 67.6 0.6 1.9e-07 31.4 0.0 4.2 6 0 0 6 6 6 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO33329.1 - 1.2e-18 65.3 0.0 0.0061 16.4 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO33329.1 - 5.1e-17 60.5 0.7 0.0025 17.2 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO33329.1 - 4.9e-09 35.9 1.0 0.58 10.1 0.1 4.5 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 KOO33329.1 - 8.1e-07 28.9 0.0 0.042 13.8 0.0 2.6 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Terminase_5 PF06056.12 KOO33329.1 - 0.066 13.1 0.2 20 5.2 0.0 2.6 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) MerR-DNA-bind PF09278.11 KOO33329.1 - 0.073 13.6 7.2 0.32 11.5 0.1 4.1 5 0 0 5 5 4 0 MerR, DNA binding Pox_F11 PF04943.12 KOO33329.1 - 0.1 11.6 0.5 1.8 7.6 0.1 2.0 2 0 0 2 2 2 0 Poxvirus F11 protein FliG_M PF14841.6 KOO33329.1 - 0.13 12.5 2.0 18 5.7 0.1 2.7 2 0 0 2 2 2 0 FliG middle domain HTH_23 PF13384.6 KOO33329.1 - 0.13 12.1 4.3 67 3.5 0.0 5.0 5 0 0 5 5 5 0 Homeodomain-like domain SCRG1 PF15224.6 KOO33329.1 - 0.24 11.5 0.5 37 4.5 0.1 2.4 2 0 0 2 2 2 0 Scrapie-responsive protein 1 DUF4140 PF13600.6 KOO33329.1 - 1.2 9.7 5.2 33 5.0 0.0 3.7 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) TetR_C_31 PF17940.1 KOO33329.1 - 4 7.7 15.6 15 5.9 0.0 4.5 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain CCDC-167 PF15188.6 KOO33329.1 - 7.4 7.0 6.7 8.5 6.8 0.2 3.2 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 3Beta_HSD PF01073.19 KOO33330.1 - 5.3e-17 61.7 0.5 7.7e-17 61.2 0.5 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KOO33330.1 - 1.2e-14 54.6 0.0 1.8e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Amidohydro_2 PF04909.14 KOO33330.1 - 8.2e-14 52.1 0.1 1.8e-11 44.4 0.0 2.5 2 1 0 2 2 2 2 Amidohydrolase Epimerase PF01370.21 KOO33330.1 - 2e-10 40.6 0.0 2.7e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 KOO33330.1 - 3e-05 23.3 0.3 0.00048 19.4 0.1 2.1 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 KOO33330.1 - 0.00023 20.4 2.1 0.00068 18.9 2.1 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 KOO33330.1 - 0.00093 18.8 0.1 0.0014 18.2 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 KOO33330.1 - 0.076 12.4 0.1 0.26 10.6 0.1 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase TrkA_N PF02254.18 KOO33330.1 - 0.08 13.2 0.3 0.14 12.5 0.3 1.5 1 0 0 1 1 1 0 TrkA-N domain Lysine_decarbox PF03641.14 KOO33332.1 - 4.1e-22 78.7 0.0 5.6e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 KOO33332.1 - 7.8e-15 54.8 1.5 1.1e-14 54.3 1.5 1.3 1 0 0 1 1 1 1 SLOG cluster4 family HMA PF00403.26 KOO33332.1 - 0.00068 20.0 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Ank_5 PF13857.6 KOO33333.1 - 1.6e-08 34.6 0.4 2.1e-06 27.9 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO33333.1 - 4.1e-08 33.7 0.0 8.3e-06 26.3 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO33333.1 - 1.3e-07 31.3 0.9 0.0081 16.6 0.1 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 KOO33333.1 - 9.5e-05 22.7 1.5 0.076 13.5 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 KOO33333.1 - 0.00014 22.3 1.5 0.038 14.6 0.1 2.9 2 1 2 4 4 4 2 Ankyrin repeats (many copies) zf-HC2 PF13490.6 KOO33333.1 - 0.82 10.0 3.0 16 5.8 0.0 3.5 3 0 0 3 3 3 0 Putative zinc-finger LRR_6 PF13516.6 KOO33336.1 - 7.5e-35 116.0 17.4 4e-05 23.3 0.1 8.1 8 0 0 8 8 8 7 Leucine Rich repeat LRR_4 PF12799.7 KOO33336.1 - 0.0029 18.0 13.7 4.8 7.7 2.4 5.5 3 2 3 6 6 6 3 Leucine Rich repeats (2 copies) Lipocalin_3 PF12702.7 KOO33336.1 - 0.0058 16.7 0.1 25 5.0 0.0 4.0 1 1 2 4 4 4 1 Lipocalin-like SpoU_sub_bind PF08032.12 KOO33336.1 - 0.018 15.3 3.3 2 8.7 0.1 3.8 3 2 1 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding YycC PF14174.6 KOO33336.1 - 0.034 14.0 0.0 24 4.8 0.0 4.4 6 0 0 6 6 6 0 YycC-like protein CoatB PF10389.9 KOO33336.1 - 0.12 12.2 12.3 15 5.5 0.1 4.8 3 1 2 5 5 5 0 Bacteriophage coat protein B LRR_8 PF13855.6 KOO33336.1 - 0.66 9.8 10.7 23 4.8 0.3 5.2 5 2 0 5 5 5 0 Leucine rich repeat HTH_23 PF13384.6 KOO33337.1 - 7.1e-06 25.7 0.1 7.1e-06 25.7 0.1 3.0 3 0 0 3 3 3 1 Homeodomain-like domain rve PF00665.26 KOO33337.1 - 0.0047 17.1 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain HTH_29 PF13551.6 KOO33337.1 - 0.01 15.8 0.9 0.022 14.8 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix Ion_trans PF00520.31 KOO33338.1 - 1.3e-37 129.3 12.1 1.7e-37 129.0 12.1 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO33338.1 - 2e-05 23.5 17.0 0.01 14.6 2.0 3.6 4 0 0 4 4 4 2 Polycystin cation channel EF-hand_1 PF00036.32 KOO33338.1 - 0.0001 21.6 0.1 0.00031 20.1 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO33338.1 - 0.00034 20.3 0.0 0.0011 18.7 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO33338.1 - 0.00059 19.2 0.0 0.0013 18.1 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO33338.1 - 0.15 12.5 0.0 0.38 11.2 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Syndecan PF01034.20 KOO33338.1 - 1.8 8.6 3.8 6.1 6.8 2.1 2.6 2 0 0 2 2 2 0 Syndecan domain DUF5090 PF17009.5 KOO33338.1 - 3 7.8 10.4 0.51 10.3 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF5090) Peptidase_S28 PF05577.12 KOO33339.1 - 3.8e-79 266.5 0.0 5e-79 266.1 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 KOO33339.1 - 0.0051 15.5 0.1 0.67 8.6 0.0 2.2 2 0 0 2 2 2 2 PS-10 peptidase S37 Peptidase_S9 PF00326.21 KOO33339.1 - 0.008 15.7 0.1 0.016 14.6 0.1 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2920 PF11144.8 KOO33339.1 - 0.25 10.4 0.0 0.36 9.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Nucleotid_trans PF03407.16 KOO33341.1 - 2.3e-27 96.4 0.0 2.3e-26 93.1 0.0 2.1 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase FKBP_C PF00254.28 KOO33342.1 - 5.8e-31 106.7 0.0 7.9e-31 106.2 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase UBA_4 PF14555.6 KOO33342.1 - 0.0046 16.8 0.2 0.01 15.7 0.2 1.6 1 0 0 1 1 1 1 UBA-like domain Pkinase PF00069.25 KOO33343.1 - 3.3e-38 131.6 0.0 6e-38 130.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33343.1 - 3.8e-38 131.3 0.0 8.6e-38 130.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase DUF2525 PF10733.9 KOO33343.1 - 0.24 11.7 0.6 0.58 10.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2525) Chlam_PMP PF02415.17 KOO33344.1 - 0.042 14.3 17.1 3.5 8.3 0.5 4.9 4 0 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat S4 PF01479.25 KOO33344.1 - 0.16 11.7 1.1 14 5.5 0.0 2.7 2 0 0 2 2 2 0 S4 domain TGT_C2 PF14810.6 KOO33345.1 - 0.15 12.2 0.0 16 5.7 0.0 2.4 2 0 0 2 2 2 0 Patch-forming domain C2 of tRNA-guanine transglycosylase HAGH_C PF16123.5 KOO33346.1 - 2e-10 41.0 0.1 4.2e-10 40.0 0.1 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 KOO33346.1 - 6.2e-09 36.1 0.0 1.4e-08 35.0 0.0 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOO33346.1 - 0.00065 19.3 0.1 0.0029 17.1 0.0 2.1 2 1 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.12 KOO33346.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Tho1_MOS11_C PF18592.1 KOO33347.1 - 1.3e-05 24.9 8.3 0.00098 18.9 0.7 3.4 2 1 2 4 4 4 4 Tho1/MOS11 C-terminal domain DNAPolymera_Pol PF11590.8 KOO33347.1 - 0.098 12.6 0.5 0.098 12.6 0.5 2.0 3 0 0 3 3 3 0 DNA polymerase catalytic subunit Pol MgtE_N PF03448.17 KOO33348.1 - 0.018 15.6 4.6 3.8 8.2 0.9 3.2 1 1 1 3 3 3 0 MgtE intracellular N domain DUF4930 PF16284.5 KOO33348.1 - 1.1 9.2 7.0 4.7 7.2 1.1 3.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4930) Abhydrolase_2 PF02230.16 KOO33349.1 - 4.4e-21 75.7 0.0 1.4e-20 74.0 0.0 1.7 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase PIH1_CS PF18201.1 KOO33349.1 - 5.5e-06 26.7 0.0 8.3e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 PIH1 CS-like domain Hydrolase_4 PF12146.8 KOO33349.1 - 0.00013 21.3 0.1 0.14 11.4 0.1 2.7 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 KOO33349.1 - 0.0018 18.2 0.3 0.0044 16.9 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOO33349.1 - 0.011 15.2 0.0 0.029 13.9 0.0 1.6 1 1 1 2 2 2 0 Prolyl oligopeptidase family Lipase_3 PF01764.25 KOO33349.1 - 0.045 13.6 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DLH PF01738.18 KOO33349.1 - 0.072 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Lipase PF00151.19 KOO33349.1 - 0.22 10.8 0.1 0.31 10.3 0.1 1.1 1 0 0 1 1 1 0 Lipase EPL1 PF10513.9 KOO33350.1 - 1.3e-08 35.3 0.0 2.3e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-CCCH PF00642.24 KOO33350.1 - 0.7 9.9 4.7 1.2 9.1 4.7 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KOO33350.1 - 0.8 9.6 4.3 1.8 8.5 4.3 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOO33350.1 - 2.7 8.2 10.1 5.1 7.3 10.1 1.5 1 0 0 1 1 1 0 Zinc finger domain Nucleotid_trans PF03407.16 KOO33351.1 - 2.2e-15 57.2 0.0 4.9e-14 52.8 0.0 2.4 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase AAA PF00004.29 KOO33352.1 - 9.8e-08 32.5 0.0 1.4e-07 32.0 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOO33352.1 - 6.3e-05 22.8 0.0 9.4e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KOO33352.1 - 0.0003 20.6 0.0 0.0011 18.8 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 KOO33352.1 - 0.001 18.5 0.0 0.16 11.4 0.0 2.2 2 0 0 2 2 2 2 Bacterial TniB protein Viral_helicase1 PF01443.18 KOO33352.1 - 0.0024 17.7 0.0 0.0035 17.1 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KOO33352.1 - 0.0086 16.3 0.1 1.1 9.5 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO33352.1 - 0.011 15.7 0.1 0.033 14.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF3709 PF12493.8 KOO33352.1 - 0.078 13.0 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3709) Mg_chelatase PF01078.21 KOO33352.1 - 0.12 11.7 0.1 0.33 10.3 0.0 1.5 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 KOO33353.1 - 5.2e-13 49.6 0.1 1.4e-12 48.1 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KOO33353.1 - 1.4e-06 27.9 0.2 0.035 13.5 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_lid_6 PF17866.1 KOO33353.1 - 2.3e-05 24.5 4.7 8.6e-05 22.6 4.7 2.0 1 0 0 1 1 1 1 AAA lid domain AAA_22 PF13401.6 KOO33353.1 - 8.7e-05 22.8 0.1 0.051 13.9 0.2 2.5 1 1 1 2 2 2 2 AAA domain Sigma54_activat PF00158.26 KOO33353.1 - 0.00011 22.0 0.0 0.27 10.9 0.0 2.3 1 1 1 2 2 2 2 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 KOO33353.1 - 0.00053 20.1 0.0 0.0015 18.6 0.0 1.7 2 0 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.12 KOO33353.1 - 0.00064 19.5 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Torsin PF06309.11 KOO33353.1 - 0.0012 19.0 0.0 0.0025 17.9 0.0 1.5 1 0 0 1 1 1 1 Torsin MCM PF00493.23 KOO33353.1 - 0.0022 17.1 0.4 0.011 14.9 0.0 2.2 2 1 0 2 2 2 1 MCM P-loop domain AAA_18 PF13238.6 KOO33353.1 - 0.0063 17.1 0.7 0.024 15.2 0.3 2.3 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 KOO33353.1 - 0.0085 16.2 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 KOO33353.1 - 0.021 15.1 2.4 1.1 9.5 0.0 3.5 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 KOO33353.1 - 0.036 14.1 0.1 0.11 12.5 0.1 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KOO33353.1 - 0.046 13.5 0.1 0.13 12.0 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.6 KOO33353.1 - 0.057 13.8 0.2 0.29 11.5 0.1 2.1 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 KOO33353.1 - 0.11 13.0 0.1 0.41 11.2 0.0 1.9 2 0 0 2 2 2 0 ABC transporter TsaE PF02367.17 KOO33353.1 - 0.14 12.1 0.1 1.1 9.3 0.1 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 KOO33353.1 - 0.15 11.8 0.1 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO33353.1 - 2 8.8 7.2 1.9 8.8 3.3 3.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_lid_6 PF17866.1 KOO33354.1 - 0.0034 17.5 0.1 0.01 16.0 0.1 1.9 1 0 0 1 1 1 1 AAA lid domain F5_F8_type_C PF00754.25 KOO33355.1 - 0.0034 17.5 0.0 0.0074 16.4 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain hSac2 PF12456.8 KOO33356.1 - 1.4e-10 40.9 0.0 2.6e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Inositol phosphatase Ldh_1_C PF02866.18 KOO33356.1 - 0.1 12.5 0.3 0.17 11.8 0.3 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain DUF2505 PF10698.9 KOO33357.1 - 1.8e-09 37.9 0.0 3.1e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) Ank_2 PF12796.7 KOO33358.1 - 3.2e-17 62.9 0.1 9.7e-09 35.7 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO33358.1 - 3.5e-17 62.2 1.7 5.6e-09 36.1 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO33358.1 - 7.9e-17 61.4 0.1 7.7e-14 51.9 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33358.1 - 2.3e-15 55.2 0.0 0.00014 22.0 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO33358.1 - 6.6e-15 54.8 0.3 5.8e-05 23.4 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat PspA_IM30 PF04012.12 KOO33359.1 - 0.023 14.3 1.1 0.023 14.3 1.1 1.7 2 0 0 2 2 2 0 PspA/IM30 family T3SS_needle_E PF08988.10 KOO33359.1 - 3.7 7.8 8.2 3.4 7.9 0.7 2.7 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle SET PF00856.28 KOO33360.1 - 0.0062 16.9 0.0 0.0092 16.4 0.0 1.3 1 0 0 1 1 1 1 SET domain XPG_N PF00752.17 KOO33362.1 - 0.11 13.0 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 XPG N-terminal domain TTL PF03133.15 KOO33363.1 - 2.3e-69 233.8 0.0 1.3e-68 231.3 0.0 1.9 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO33363.1 - 1.9e-10 40.5 0.2 2.2e-06 27.1 0.0 3.4 2 1 1 3 3 3 3 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO33363.1 - 0.00037 19.8 0.0 0.01 15.1 0.0 2.2 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 KOO33363.1 - 0.18 11.8 0.0 1.4 8.9 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain Pkinase PF00069.25 KOO33364.1 - 3.3e-60 203.7 0.0 3.8e-60 203.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33364.1 - 9.6e-34 116.8 0.0 1.1e-33 116.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO33364.1 - 6.4e-05 22.4 0.0 8.9e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO33364.1 - 0.0007 19.6 0.4 0.0018 18.3 0.2 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO33364.1 - 0.00078 18.8 0.0 0.0089 15.4 0.0 2.2 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOO33364.1 - 0.0016 17.5 0.0 0.002 17.1 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 KOO33364.1 - 0.14 11.8 0.1 0.31 10.6 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YukC PF10140.9 KOO33364.1 - 0.15 10.9 0.0 0.26 10.1 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC T3SSipB PF16535.5 KOO33365.1 - 2.5 8.5 5.7 4 7.9 0.3 2.3 2 0 0 2 2 2 0 Type III cell invasion protein SipB Glyco_transf_29 PF00777.18 KOO33366.1 - 2e-29 102.8 0.0 6.1e-28 98.0 0.0 2.4 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) ABC2_membrane PF01061.24 KOO33367.1 - 4.1e-16 59.1 0.4 6.3e-16 58.4 0.4 1.2 1 0 0 1 1 1 1 ABC-2 type transporter EF-hand_6 PF13405.6 KOO33367.1 - 1.9e-14 52.2 4.8 0.00045 19.9 0.0 3.9 3 0 0 3 3 3 3 EF-hand domain ABC_tran PF00005.27 KOO33367.1 - 6.5e-13 49.4 0.0 2.8e-12 47.3 0.0 2.0 2 1 1 3 3 3 1 ABC transporter EF-hand_1 PF00036.32 KOO33367.1 - 4.4e-12 44.6 13.3 0.0006 19.2 0.1 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO33367.1 - 6.3e-08 33.0 5.2 0.00017 21.9 0.2 3.1 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO33367.1 - 5.1e-07 29.4 4.6 0.00015 21.6 0.6 3.5 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO33367.1 - 0.00027 20.3 15.4 0.00041 19.7 0.1 4.0 4 0 0 4 4 4 2 EF hand AAA_21 PF13304.6 KOO33367.1 - 0.016 15.0 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 KOO33367.1 - 0.03 13.4 1.1 0.049 12.7 1.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein FKBP_N PF01346.18 KOO33367.1 - 0.059 14.3 0.7 14 6.7 0.0 2.6 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase FA_hydroxylase PF04116.13 KOO33368.1 - 5.2e-19 68.9 10.1 1.2e-18 67.8 10.1 1.6 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily PsbI PF02532.14 KOO33368.1 - 0.18 11.8 0.2 0.55 10.2 0.2 1.8 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Croc_4 PF17691.1 KOO33368.1 - 0.19 11.8 4.0 0.23 11.5 0.0 2.3 2 0 0 2 2 2 0 Contingent replication of cDNA 4 Protocadherin PF08374.11 KOO33369.1 - 0.078 12.9 0.2 0.19 11.7 0.2 1.6 1 0 0 1 1 1 0 Protocadherin CcmD PF04995.14 KOO33369.1 - 3.3 7.9 7.2 0.54 10.4 2.0 2.5 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) MMR_HSR1 PF01926.23 KOO33370.1 - 2.1e-19 69.7 0.0 2.8e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOO33370.1 - 1.6e-06 27.7 0.0 1.9e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KOO33370.1 - 3.7e-06 26.9 1.3 6.3e-05 22.9 0.1 2.4 1 1 2 3 3 3 1 RsgA GTPase Dynamin_N PF00350.23 KOO33370.1 - 0.00015 21.9 0.2 0.12 12.4 0.0 2.2 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 KOO33370.1 - 0.0018 17.6 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 KOO33370.1 - 0.0048 16.4 0.2 0.046 13.2 0.2 2.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Resolvase PF00239.21 KOO33370.1 - 0.0085 16.2 0.6 0.013 15.7 0.6 1.2 1 0 0 1 1 1 1 Resolvase, N terminal domain GTP_EFTU PF00009.27 KOO33370.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Nuc_deoxyri_tr3 PF11071.8 KOO33370.1 - 0.014 15.5 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase YtoQ DHHA2 PF02833.14 KOO33370.1 - 0.047 13.9 0.0 0.064 13.4 0.0 1.3 1 0 0 1 1 1 0 DHHA2 domain AAA_22 PF13401.6 KOO33370.1 - 0.15 12.4 0.1 0.3 11.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain LRR_6 PF13516.6 KOO33371.1 - 1.2e-13 49.9 2.7 0.042 13.9 0.0 8.8 9 0 0 9 9 9 4 Leucine Rich repeat LRR_4 PF12799.7 KOO33371.1 - 4.2e-11 42.9 0.1 0.87 10.1 0.0 7.0 3 3 3 7 7 7 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO33371.1 - 0.002 18.4 6.4 66 4.6 0.4 6.6 7 1 0 7 7 7 0 Leucine Rich Repeat YadA_head PF05658.14 KOO33372.1 - 0.11 12.9 2.4 0.11 12.9 2.4 5.1 7 1 1 8 8 8 0 Head domain of trimeric autotransporter adhesin KRTAP PF11759.8 KOO33372.1 - 0.22 12.1 20.2 7.8e+02 0.7 20.2 2.3 1 1 0 1 1 1 0 Keratin-associated matrix Rad60-SLD PF11976.8 KOO33373.1 - 6.9e-15 54.6 0.0 1.2e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOO33373.1 - 4.4e-06 26.3 0.0 1e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family ERM PF00769.19 KOO33373.1 - 0.00019 21.4 15.6 0.00019 21.4 15.6 1.8 2 0 0 2 2 1 1 Ezrin/radixin/moesin family Borrelia_P83 PF05262.11 KOO33373.1 - 0.0026 16.3 16.2 0.004 15.7 16.2 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein TMPIT PF07851.13 KOO33373.1 - 2.3 7.4 4.7 3.7 6.7 4.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein RRF PF01765.19 KOO33373.1 - 3.3 7.6 13.6 7.3 6.5 13.6 1.5 1 0 0 1 1 1 0 Ribosome recycling factor Red1 PF07964.11 KOO33373.1 - 3.7 5.7 7.6 5.2 5.2 7.6 1.1 1 0 0 1 1 1 0 Rec10 / Red1 DUF3584 PF12128.8 KOO33373.1 - 3.8 4.9 18.4 5.8 4.3 18.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) PPP4R2 PF09184.11 KOO33373.1 - 3.9 7.0 13.8 6.9 6.2 13.8 1.4 1 0 0 1 1 1 0 PPP4R2 HSP70 PF00012.20 KOO33373.1 - 5.9 4.9 15.0 11 4.0 15.0 1.4 1 0 0 1 1 1 0 Hsp70 protein Nucleoporin_FG PF13634.6 KOO33373.1 - 6.8 7.6 24.7 12 6.8 24.1 1.8 1 1 0 1 1 1 0 Nucleoporin FG repeat region DUF4407 PF14362.6 KOO33373.1 - 8 5.7 18.2 15 4.8 18.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3450 PF11932.8 KOO33373.1 - 8.1 5.7 13.6 3 7.1 10.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Glyco_hydro_18 PF00704.28 KOO33375.1 - 7.1e-07 29.3 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Transmemb_17 PF09799.9 KOO33376.1 - 9.6e-24 84.0 10.7 1.5e-23 83.4 10.7 1.3 1 0 0 1 1 1 1 Predicted membrane protein FYVE PF01363.21 KOO33377.1 - 1.7e-17 63.3 15.1 3.3e-17 62.4 15.1 1.4 1 0 0 1 1 1 1 FYVE zinc finger PH_12 PF16457.5 KOO33377.1 - 0.089 13.3 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain FYVE_2 PF02318.16 KOO33377.1 - 0.99 9.6 10.1 2.2 8.5 10.1 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger AAA_16 PF13191.6 KOO33379.1 - 3.1e-09 37.4 0.2 1.3e-08 35.4 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 KOO33379.1 - 6.1e-08 32.8 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 KOO33379.1 - 0.0015 17.8 0.0 0.045 13.0 0.0 2.2 1 1 0 2 2 2 1 KAP family P-loop domain NB-ARC PF00931.22 KOO33379.1 - 0.017 14.3 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain PIF1 PF05970.14 KOO33379.1 - 0.046 12.9 0.0 0.065 12.4 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase Abhydrolase_9 PF10081.9 KOO33379.1 - 0.09 11.8 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta-hydrolase family LRR_6 PF13516.6 KOO33380.1 - 1.1e-11 43.8 0.7 0.12 12.5 0.0 4.6 5 0 0 5 5 5 4 Leucine Rich repeat LRR_1 PF00560.33 KOO33380.1 - 0.025 15.1 0.1 18 6.4 0.1 4.1 5 0 0 5 5 5 0 Leucine Rich Repeat Glucokinase PF02685.16 KOO33382.1 - 4.7e-78 262.4 0.0 1.3e-43 149.2 0.0 2.2 2 0 0 2 2 2 2 Glucokinase Methyltransf_16 PF10294.9 KOO33382.1 - 2.8e-17 63.0 0.0 5.2e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase EF-hand_1 PF00036.32 KOO33382.1 - 2.5e-06 26.6 0.2 4.9e-06 25.7 0.2 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO33382.1 - 7.1e-06 25.5 0.4 2.6e-05 23.8 0.2 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO33382.1 - 4.6e-05 23.8 0.1 0.00011 22.6 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO33382.1 - 0.00023 20.5 0.2 0.00046 19.6 0.2 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO33382.1 - 0.0015 18.4 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair PrmA PF06325.13 KOO33382.1 - 0.02 14.3 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KOO33382.1 - 0.022 14.3 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PAN_4 PF14295.6 KOO33382.1 - 0.047 13.6 0.3 0.16 11.9 0.3 1.9 1 0 0 1 1 1 0 PAN domain Methyltransf_23 PF13489.6 KOO33382.1 - 0.057 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 KOO33382.1 - 0.077 12.6 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 KOO33382.1 - 0.12 13.1 0.0 0.29 11.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MTHFR PF02219.17 KOO33383.1 - 1.1e-05 24.9 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF1835 PF08874.10 KOO33385.1 - 0.031 14.5 0.9 0.054 13.7 0.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1835) DUF4411 PF14367.6 KOO33385.1 - 0.031 14.2 1.3 0.031 14.2 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) TRAP_alpha PF03896.16 KOO33385.1 - 2.4 7.3 5.8 2.6 7.2 5.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4332 PF14229.6 KOO33386.1 - 0.021 15.1 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) PALP PF00291.25 KOO33387.1 - 0.00055 19.4 0.0 0.00098 18.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF1971 PF09313.11 KOO33387.1 - 0.023 14.7 0.0 0.96 9.5 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1971) AnkUBD PF18418.1 KOO33387.1 - 0.11 12.6 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Ankyrin ubiquitin-binding domain Trp_syntA PF00290.20 KOO33388.1 - 1.3e-68 230.7 0.2 1.2e-67 227.5 0.2 2.0 1 1 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 KOO33388.1 - 1.5e-26 93.5 0.1 3.5e-26 92.3 0.1 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme HORMA PF02301.18 KOO33389.1 - 3.2e-24 85.7 0.5 1.5e-23 83.5 0.5 1.8 1 1 0 1 1 1 1 HORMA domain Utp14 PF04615.13 KOO33390.1 - 2.6e-99 333.9 79.1 7.4e-50 170.3 66.4 3.0 1 1 2 3 3 3 2 Utp14 protein Hydant_A_N PF05378.13 KOO33390.1 - 2.4 7.8 7.0 0.99 9.1 2.6 2.3 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase N-terminal region Leucyl-specific PF14795.6 KOO33390.1 - 3.4 7.8 16.7 0.42 10.7 1.5 3.7 3 1 0 3 3 3 0 Leucine-tRNA synthetase-specific domain TFIIF_alpha PF05793.12 KOO33390.1 - 10 4.6 45.3 0.095 11.3 10.9 2.5 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Ank_4 PF13637.6 KOO33391.1 - 3.1e-10 40.4 0.3 2e-08 34.6 0.2 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO33391.1 - 1.3e-09 38.0 0.7 0.00018 21.8 0.2 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 KOO33391.1 - 6e-09 36.4 0.0 2.5e-08 34.4 0.0 2.0 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO33391.1 - 1.5e-07 31.6 1.4 6.6e-05 23.1 0.4 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33391.1 - 5e-06 26.5 0.9 0.0012 19.1 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Elongin_A PF06881.11 KOO33391.1 - 0.00031 21.2 0.1 0.0005 20.6 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box-like PF12937.7 KOO33391.1 - 0.00051 19.9 3.1 0.00052 19.8 1.4 2.0 2 0 0 2 2 2 1 F-box-like MANEC PF07502.14 KOO33392.1 - 2 8.7 5.8 1.6 9.0 4.1 1.7 2 0 0 2 2 2 0 MANEC domain Isochorismatase PF00857.20 KOO33393.1 - 4.4e-30 105.2 0.0 8.3e-30 104.2 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family 2OG-FeII_Oxy_2 PF13532.6 KOO33393.1 - 1.8e-11 44.6 0.0 3.3e-11 43.7 0.0 1.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-NADH-PPase PF09297.11 KOO33393.1 - 0.0024 17.5 0.8 0.0057 16.3 0.8 1.6 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Oxygenase-NA PF09859.9 KOO33393.1 - 0.022 14.3 0.0 0.069 12.7 0.0 1.8 2 0 0 2 2 2 0 Oxygenase, catalysing oxidative methylation of damaged DNA TF_Zn_Ribbon PF08271.12 KOO33393.1 - 0.064 12.8 0.6 0.14 11.6 0.6 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding 2OG-FeII_Oxy_5 PF13759.6 KOO33393.1 - 0.12 12.8 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase SesA PF17107.5 KOO33394.1 - 0.061 13.5 10.7 0.072 13.3 2.4 3.2 1 1 2 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DapB_C PF05173.14 KOO33395.1 - 7.3e-18 64.7 0.0 1.1e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, C-terminus DapB_N PF01113.20 KOO33395.1 - 3.1e-16 59.6 0.0 5.5e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Tape_meas_lam_C PF09718.10 KOO33395.1 - 0.11 12.6 0.4 0.44 10.7 0.4 2.0 1 1 0 1 1 1 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) DUF167 PF02594.16 KOO33396.1 - 1.8e-13 50.4 0.1 4.3e-13 49.2 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised ACR, YggU family COG1872 Actin PF00022.19 KOO33398.1 - 4.3e-65 219.9 0.0 1.5e-63 214.8 0.0 2.5 1 1 1 2 2 2 1 Actin MreB_Mbl PF06723.13 KOO33398.1 - 0.14 11.0 0.0 3.6 6.3 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein FKBP_C PF00254.28 KOO33399.1 - 1.2e-19 70.4 0.0 2.3e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_5 PF13202.6 KOO33399.1 - 3.1e-06 26.4 2.0 0.008 15.6 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO33399.1 - 6.6e-06 25.3 2.7 0.012 15.1 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO33399.1 - 6.8e-06 25.6 1.1 0.0027 17.5 0.1 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO33399.1 - 1.4e-05 25.5 1.5 4.8e-05 23.7 1.5 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO33399.1 - 9.8e-05 22.1 0.8 0.11 12.4 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair CNP1 PF08750.11 KOO33399.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 CNP1-like family GHMP_kinases_C PF08544.13 KOO33400.1 - 3.5e-10 40.1 0.1 1.6e-09 38.0 0.1 2.2 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 KOO33400.1 - 9.9e-06 25.7 2.1 4.4e-05 23.6 0.2 2.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain ATG11 PF10377.9 KOO33401.1 - 7.3e-05 22.8 0.0 7.9e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 11 Filamin PF00630.19 KOO33402.1 - 4.9e-40 136.5 0.0 8.5e-08 33.0 0.0 6.1 5 1 0 5 5 5 5 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO33402.1 - 2.1e-10 40.8 12.8 0.00086 19.6 0.0 6.0 7 0 0 7 7 7 3 Invasin, domain 3 MG2 PF01835.19 KOO33402.1 - 0.0019 18.6 0.0 0.064 13.7 0.0 3.2 3 0 0 3 3 3 1 MG2 domain VWA PF00092.28 KOO33403.1 - 2.8e-30 105.9 0.0 7.1e-19 68.7 0.0 2.0 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 KOO33403.1 - 2.1e-20 73.4 0.3 1.8e-10 41.4 0.0 2.8 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 KOO33403.1 - 1.3e-10 41.1 0.2 0.00024 20.6 0.0 2.3 2 1 0 2 2 2 2 VWA domain containing CoxE-like protein LexA_DNA_bind PF01726.16 KOO33403.1 - 0.0042 16.8 0.0 0.69 9.7 0.0 3.1 3 0 0 3 3 3 1 LexA DNA binding domain DUF1194 PF06707.11 KOO33403.1 - 0.0075 15.5 1.1 0.035 13.3 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1194) OB_aCoA_assoc PF01796.17 KOO33403.1 - 0.059 13.4 0.0 9.6 6.3 0.0 2.7 3 0 0 3 3 3 0 DUF35 OB-fold domain, acyl-CoA-associated ABC2_membrane PF01061.24 KOO33404.1 - 1.5e-34 119.3 19.5 1.5e-34 119.3 19.5 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KOO33404.1 - 3.2e-28 99.0 0.0 4.5e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOO33404.1 - 2.1e-07 31.1 0.0 0.0028 17.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 KOO33404.1 - 0.00017 20.8 25.0 0.00044 19.5 25.0 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 KOO33404.1 - 0.00056 19.9 0.0 0.00098 19.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 KOO33404.1 - 0.00063 19.4 0.2 0.0016 18.1 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 KOO33404.1 - 0.00064 19.2 0.1 0.72 9.2 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO33404.1 - 0.0012 19.3 0.0 0.004 17.6 0.0 2.0 2 0 0 2 2 1 1 AAA ATPase domain PDR_assoc PF08370.11 KOO33404.1 - 0.0084 15.8 2.1 0.027 14.2 2.1 1.8 1 0 0 1 1 1 1 Plant PDR ABC transporter associated MMR_HSR1 PF01926.23 KOO33404.1 - 0.01 15.9 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 KOO33404.1 - 0.016 15.5 0.0 0.12 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOO33404.1 - 0.019 15.5 0.0 0.03 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain PDR_CDR PF06422.12 KOO33404.1 - 0.064 13.2 0.6 0.064 13.2 0.6 2.2 2 0 0 2 2 2 0 CDR ABC transporter cobW PF02492.19 KOO33404.1 - 0.075 12.6 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 KOO33404.1 - 0.076 12.1 1.1 0.13 11.3 0.2 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Dynamin_N PF00350.23 KOO33404.1 - 0.076 13.1 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Dynamin family AAA_33 PF13671.6 KOO33404.1 - 0.1 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOO33404.1 - 0.1 12.8 0.1 0.17 12.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOO33404.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 KOO33404.1 - 0.13 12.0 0.7 0.24 11.1 0.2 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 KOO33404.1 - 0.14 11.7 0.1 0.35 10.4 0.1 1.6 2 0 0 2 2 1 0 Ferrous iron transport protein B AAA_24 PF13479.6 KOO33404.1 - 0.29 10.8 0.2 0.73 9.5 0.1 1.6 2 0 0 2 2 2 0 AAA domain TFIIA PF03153.13 KOO33405.1 - 0.35 10.8 14.2 0.44 10.5 14.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4778 PF16008.5 KOO33405.1 - 0.37 10.8 6.4 0.53 10.3 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) DUF5427 PF10310.9 KOO33405.1 - 1.8 7.4 15.9 2.5 6.9 15.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF4355 PF14265.6 KOO33405.1 - 3.5 7.9 19.8 7.9 6.7 19.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) Neur_chan_memb PF02932.16 KOO33405.1 - 3.7 7.5 5.1 5.6 6.9 5.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Methyltransf_16 PF10294.9 KOO33406.1 - 1.3e-14 54.3 0.0 1.6e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 KOO33406.1 - 0.00035 20.5 0.0 0.00037 20.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain SET PF00856.28 KOO33407.1 - 1.2e-12 48.5 0.0 4.9e-12 46.6 0.0 2.0 1 1 0 1 1 1 1 SET domain Ribosomal_S3_C PF00189.20 KOO33408.1 - 1e-20 74.0 2.6 6.3e-20 71.5 3.1 1.9 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 KOO33408.1 - 2.9e-11 43.0 0.4 7e-11 41.8 0.4 1.7 1 0 0 1 1 1 1 KH domain Lipase_GDSL_2 PF13472.6 KOO33409.1 - 0.0024 18.3 0.0 0.0048 17.3 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family ATG_C PF09333.11 KOO33409.1 - 0.14 12.5 0.1 0.28 11.5 0.1 1.4 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain MOFRL PF05161.13 KOO33410.1 - 5.7 7.2 6.4 20 5.4 0.6 2.8 2 1 0 2 2 2 0 MOFRL family DUF4705 PF15788.5 KOO33411.1 - 0.42 10.9 6.6 0.31 11.3 1.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4705) Inhibitor_I68 PF10468.9 KOO33411.1 - 3 8.3 6.8 0.93 9.9 3.4 1.9 2 0 0 2 2 2 0 Carboxypeptidase inhibitor I68 Ank_2 PF12796.7 KOO33414.1 - 5.2e-170 552.5 82.9 5e-19 68.7 0.6 10.1 1 1 13 14 14 14 14 Ankyrin repeats (3 copies) Ank PF00023.30 KOO33414.1 - 1.6e-89 290.7 33.6 3.7e-05 24.0 0.0 17.9 17 1 1 18 18 18 17 Ankyrin repeat Ank_4 PF13637.6 KOO33414.1 - 4.7e-84 275.8 18.8 2.4e-09 37.5 0.1 13.9 3 2 10 14 14 14 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33414.1 - 8.6e-83 262.3 11.3 0.00015 21.9 0.0 17.7 18 0 0 18 18 18 15 Ankyrin repeat Ank_5 PF13857.6 KOO33414.1 - 1.2e-62 207.2 37.1 1.8e-08 34.4 0.1 14.6 5 2 10 15 15 15 15 Ankyrin repeats (many copies) DUF1296 PF06972.11 KOO33414.1 - 2.2e-08 34.1 5.9 1.4e+02 2.7 0.0 11.0 12 0 0 12 12 12 0 Protein of unknown function (DUF1296) 3HCDH_RFF PF18321.1 KOO33414.1 - 2.7e-08 34.1 43.4 1.3 9.5 0.1 12.4 5 3 8 13 13 13 4 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Ser_hydrolase PF06821.13 KOO33414.1 - 1.8e-05 24.6 35.2 0.48 10.3 0.5 9.7 2 1 9 11 11 11 5 Serine hydrolase Phage_tail_U PF06141.11 KOO33414.1 - 2.5e-05 24.6 1.2 7.3 7.0 0.0 4.9 5 1 1 6 6 6 2 Phage minor tail protein U DUF5583 PF17821.1 KOO33414.1 - 0.00014 21.8 1.4 8.4 6.4 0.0 5.9 1 1 6 7 7 7 1 Family of unknown function (DUF5583) PP_kinase_C_1 PF17941.1 KOO33414.1 - 0.014 15.0 23.2 42 3.6 0.0 10.2 2 2 7 11 11 11 0 Polyphosphate kinase C-terminal domain 1 DUF1835 PF08874.10 KOO33414.1 - 0.076 13.2 0.1 12 6.1 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF1835) NTP_transf_3 PF12804.7 KOO33417.1 - 2.5e-08 34.5 0.0 5.9e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 KOO33417.1 - 0.0022 17.8 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase AAA_2 PF07724.14 KOO33418.1 - 4.4e-19 69.2 0.0 9.5e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 KOO33418.1 - 3e-10 40.6 0.0 7.8e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO33418.1 - 1.9e-07 31.1 0.0 6.2e-07 29.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Torsin PF06309.11 KOO33418.1 - 3.5e-05 23.9 0.0 6.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Torsin AAA_16 PF13191.6 KOO33418.1 - 0.00022 21.7 6.4 0.00056 20.3 0.2 3.6 2 2 1 3 3 3 1 AAA ATPase domain Sigma54_activat PF00158.26 KOO33418.1 - 0.00075 19.2 0.0 0.0046 16.7 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_22 PF13401.6 KOO33418.1 - 0.0034 17.6 0.0 0.015 15.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KOO33418.1 - 0.026 14.1 0.2 1.5 8.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KOO33418.1 - 0.034 14.5 0.0 0.073 13.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase ResIII PF04851.15 KOO33418.1 - 0.099 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NACHT PF05729.12 KOO33418.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 KOO33418.1 - 0.13 12.3 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 KOO33418.1 - 0.17 11.0 0.0 0.53 9.4 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_7 PF12775.7 KOO33418.1 - 0.17 11.4 0.0 0.43 10.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 KOO33418.1 - 0.22 12.0 0.7 0.47 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain GBP PF02263.19 KOO33419.1 - 1.1e-08 34.7 0.0 1.8e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MscS_TM PF12794.7 KOO33419.1 - 0.05 12.5 0.6 0.081 11.8 0.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 ATPase_2 PF01637.18 KOO33419.1 - 0.17 11.8 0.0 0.45 10.4 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea adh_short PF00106.25 KOO33420.1 - 4.1e-16 59.0 0.0 1.2e-07 31.3 0.0 2.7 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO33420.1 - 3.1e-14 53.1 0.0 1.2e-08 34.8 0.0 2.6 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Spt4 PF06093.13 KOO33420.1 - 0.017 15.2 2.0 0.026 14.6 0.7 2.0 3 0 0 3 3 3 0 Spt4/RpoE2 zinc finger Response_reg PF00072.24 KOO33421.1 - 3.3e-14 53.0 0.0 5.1e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Cupin_2 PF07883.11 KOO33422.1 - 9.1e-07 28.5 0.1 3.4e-06 26.7 0.2 1.9 2 0 0 2 2 2 1 Cupin domain AraC_binding PF02311.19 KOO33422.1 - 0.0053 16.7 0.1 0.045 13.7 0.1 2.1 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_3 PF05899.12 KOO33422.1 - 0.058 13.1 0.0 0.27 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Ank_2 PF12796.7 KOO33423.1 - 6.5e-12 45.9 0.1 1.9e-11 44.4 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33423.1 - 2.1e-10 40.9 0.1 1e-05 25.9 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO33423.1 - 7.4e-10 38.8 0.1 6.4e-05 23.2 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat ART PF01129.18 KOO33423.1 - 3.7e-09 36.2 0.4 1.2e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase Ank_3 PF13606.6 KOO33423.1 - 4.9e-09 35.7 0.1 0.0038 17.6 0.0 4.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KOO33423.1 - 1.3e-07 31.8 0.4 0.00074 19.8 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Pex16 PF08610.10 KOO33423.1 - 8.5e-06 25.2 0.6 9.1e-05 21.8 0.6 2.1 1 1 0 1 1 1 1 Peroxisomal membrane protein (Pex16) ADPrib_exo_Tox PF03496.14 KOO33423.1 - 0.00028 20.3 0.0 0.00082 18.8 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme LRR_4 PF12799.7 KOO33424.1 - 3.1e-06 27.4 0.9 0.011 16.1 0.6 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO33424.1 - 0.0032 17.2 0.2 0.049 13.4 0.3 2.2 1 1 1 2 2 2 2 Leucine rich repeat MlrC_C PF07171.12 KOO33424.1 - 0.069 13.3 0.3 0.13 12.4 0.3 1.4 1 0 0 1 1 1 0 MlrC C-terminus PWWP PF00855.17 KOO33426.1 - 1.3e-10 41.5 0.4 3.3e-10 40.2 0.4 1.7 1 0 0 1 1 1 1 PWWP domain Glyco_trans_1_4 PF13692.6 KOO33427.1 - 2.7e-14 53.7 0.0 9.5e-14 52.0 0.0 1.9 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 KOO33427.1 - 0.062 12.8 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 SPOUT_MTase PF02590.17 KOO33429.1 - 2.7e-36 124.9 0.0 5.2e-36 124.0 0.0 1.4 1 1 0 1 1 1 1 Predicted SPOUT methyltransferase Transketolase_C PF02780.20 KOO33429.1 - 0.12 12.2 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Transketolase, C-terminal domain LRR_4 PF12799.7 KOO33430.1 - 1.3e-13 50.8 17.1 1.1e-05 25.7 4.1 4.1 2 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO33430.1 - 1e-11 44.6 6.7 3e-07 30.1 1.0 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KOO33430.1 - 1.5e-07 31.1 17.3 0.00014 21.5 4.8 3.5 2 1 2 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 KOO33430.1 - 0.14 12.3 3.2 5.6 7.3 0.1 3.3 3 0 0 3 3 3 0 Leucine Rich repeat Kinesin PF00225.23 KOO33431.1 - 1.3e-66 224.8 0.0 1.9e-66 224.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO33431.1 - 3.8e-25 88.6 0.0 5.8e-25 88.0 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding SAP PF02037.27 KOO33431.1 - 2.1e-05 24.2 0.7 5.2e-05 22.9 0.7 1.8 1 0 0 1 1 1 1 SAP domain ATG16 PF08614.11 KOO33431.1 - 0.027 14.7 9.2 0.055 13.7 9.2 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 KOO33431.1 - 0.034 14.6 0.6 0.056 13.9 0.6 1.5 1 0 0 1 1 1 0 Fez1 AAA_22 PF13401.6 KOO33431.1 - 0.062 13.6 0.0 0.25 11.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain DUF4201 PF13870.6 KOO33431.1 - 0.1 12.3 0.7 0.19 11.4 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) AAA_16 PF13191.6 KOO33431.1 - 0.12 12.8 0.1 0.12 12.8 0.1 2.5 2 0 0 2 2 2 0 AAA ATPase domain Phage_GPO PF05929.11 KOO33431.1 - 0.13 11.8 6.3 0.24 11.0 6.3 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase YabA PF06156.13 KOO33431.1 - 0.17 12.6 1.6 1.2 9.8 1.4 2.4 2 1 0 2 2 2 0 Initiation control protein YabA SlyX PF04102.12 KOO33431.1 - 0.32 11.6 5.1 2.7 8.7 0.9 2.6 2 0 0 2 2 2 0 SlyX SCP-1 PF05483.12 KOO33431.1 - 0.41 8.6 3.8 0.58 8.1 3.8 1.1 1 0 0 1 1 1 0 Synaptonemal complex protein 1 (SCP-1) AAA_13 PF13166.6 KOO33431.1 - 0.52 8.9 2.9 0.42 9.2 1.6 1.4 2 0 0 2 2 2 0 AAA domain Syntaxin-6_N PF09177.11 KOO33431.1 - 0.66 10.6 2.9 2.8 8.6 2.1 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal NifQ PF04891.12 KOO33431.1 - 1.1 9.5 2.9 3.7 7.9 2.9 1.9 1 0 0 1 1 1 0 NifQ TMF_TATA_bd PF12325.8 KOO33431.1 - 1.4 9.2 8.1 4.8 7.4 7.8 2.0 2 1 0 2 2 1 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 KOO33431.1 - 6.8 5.5 6.8 11 4.8 6.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Chloroa_b-bind PF00504.21 KOO33432.1 - 5.1e-27 95.4 0.1 8.2e-27 94.7 0.1 1.3 1 1 0 1 1 1 1 Chlorophyll A-B binding protein Ank_5 PF13857.6 KOO33433.1 - 6e-13 48.7 0.5 1.7e-11 44.1 0.2 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO33433.1 - 6.9e-13 49.0 0.3 1.1e-09 38.8 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33433.1 - 1e-10 41.9 0.1 7.9e-08 32.7 0.2 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO33433.1 - 1.1e-08 35.1 0.3 0.0024 18.2 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO33433.1 - 3.4e-05 23.9 0.0 0.041 14.4 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat Gly-rich_Ago1 PF12764.7 KOO33433.1 - 0.19 12.5 0.0 0.37 11.6 0.0 1.4 1 0 0 1 1 1 0 Glycine-rich region of argonaut HECT PF00632.25 KOO33434.1 - 1.3e-05 24.9 0.0 2.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HATPase_c_3 PF13589.6 KOO33435.1 - 2.5e-11 43.5 0.0 4.3e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOO33435.1 - 2.6e-05 24.7 0.0 5.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PmbA_TldD PF01523.16 KOO33435.1 - 0.04 13.8 0.4 0.069 13.0 0.4 1.6 1 0 0 1 1 1 0 Putative modulator of DNA gyrase DEAD PF00270.29 KOO33436.1 - 1.1e-39 136.0 0.1 3e-39 134.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO33436.1 - 1.5e-18 67.2 0.0 4.1e-18 65.7 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO33436.1 - 9.1e-05 22.5 0.0 0.00014 21.9 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOO33436.1 - 0.04 13.1 0.0 0.071 12.3 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase HpcH_HpaI PF03328.14 KOO33437.1 - 4e-34 117.7 0.0 5.7e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 KOO33437.1 - 0.072 12.1 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain TAP42 PF04177.12 KOO33438.1 - 1.4e-48 165.7 0.0 1.9e-48 165.3 0.0 1.2 1 0 0 1 1 1 1 TAP42-like family ELO PF01151.18 KOO33439.1 - 2e-64 217.5 7.9 2.3e-64 217.3 7.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family SNF2_assoc PF08455.10 KOO33440.1 - 0.12 11.4 0.0 0.15 11.1 0.0 1.0 1 0 0 1 1 1 0 Bacterial SNF2 helicase associated Gly-zipper_YMGG PF13441.6 KOO33441.1 - 0.0056 16.4 6.2 0.014 15.1 6.2 1.6 1 0 0 1 1 1 1 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.6 KOO33441.1 - 0.0093 15.7 9.7 0.027 14.2 9.7 1.7 1 0 0 1 1 1 1 Glycine-zipper domain Gly-zipper_Omp PF13488.6 KOO33441.1 - 0.14 12.2 6.6 0.32 11.0 6.6 1.5 1 0 0 1 1 1 0 Glycine zipper CCDC84 PF14968.6 KOO33441.1 - 4.5 6.8 5.8 6.6 6.3 5.8 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 WD40 PF00400.32 KOO33444.1 - 2.8e-67 221.0 24.2 6.5e-09 36.3 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO33444.1 - 1e-20 74.0 6.5 0.012 14.6 0.0 7.0 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO33444.1 - 2.7e-20 71.8 6.9 0.081 12.9 0.0 7.3 7 0 0 7 7 7 7 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 KOO33444.1 - 2.1e-17 63.2 6.8 0.2 12.0 0.1 6.8 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KOO33444.1 - 4.9e-09 35.1 0.0 0.79 8.0 0.0 5.2 1 1 3 5 5 5 5 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO33444.1 - 6.5e-08 32.2 7.7 1.2 8.4 0.1 5.8 1 1 6 7 7 7 4 Neuroblastoma-amplified sequence, N terminal WD40_3 PF15911.5 KOO33444.1 - 0.0035 17.3 0.2 1.4e+02 2.5 0.0 5.9 7 0 0 7 7 7 0 WD domain, G-beta repeat CIDE-N PF02017.15 KOO33444.1 - 0.036 14.1 0.1 63 3.7 0.0 4.7 5 1 0 6 6 6 0 CIDE-N domain Spc110_C PF18520.1 KOO33444.1 - 0.045 13.4 0.3 64 3.3 0.0 4.8 5 0 0 5 5 5 0 Spindle pole body component 110 C-terminal domain DpaA_N PF16924.5 KOO33444.1 - 0.045 13.9 0.0 87 3.3 0.0 3.6 1 1 4 5 5 5 0 Dipicolinate synthase subunit A N-terminal domain DUF2789 PF10982.8 KOO33444.1 - 0.23 11.6 1.4 15 5.9 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2789) VPS13_C PF16909.5 KOO33445.1 - 4.5e-23 81.9 0.0 1.4e-21 77.0 0.0 2.2 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal IQ PF00612.27 KOO33446.1 - 4.4 7.4 11.6 0.78 9.7 1.0 3.5 3 0 0 3 3 3 0 IQ calmodulin-binding motif SGL PF08450.12 KOO33448.1 - 0.00045 19.9 0.0 3.8 7.0 0.0 4.0 2 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Kelch_6 PF13964.6 KOO33448.1 - 0.00063 19.9 0.0 11 6.5 0.0 5.0 5 0 0 5 5 5 1 Kelch motif DUF5050 PF16472.5 KOO33448.1 - 0.047 12.9 0.0 21 4.2 0.0 4.6 7 0 0 7 7 7 0 Domain of unknown function (DUF5050) DUF630 PF04783.12 KOO33448.1 - 1 9.6 4.7 0.29 11.3 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF630) DUF4419 PF14388.6 KOO33449.1 - 0.093 12.1 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4419) ExbD PF02472.16 KOO33449.1 - 0.13 12.5 0.1 0.15 12.3 0.1 1.1 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR Dpy-30 PF05186.13 KOO33451.1 - 1.8e-17 62.7 0.1 2.3e-17 62.4 0.1 1.1 1 0 0 1 1 1 1 Dpy-30 motif RIIa PF02197.17 KOO33451.1 - 0.0034 17.0 0.1 0.0066 16.1 0.1 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Myb_DNA-binding PF00249.31 KOO33452.1 - 0.056 13.6 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain PHP_C PF13263.6 KOO33452.1 - 0.075 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 PHP-associated PRAP PF15314.6 KOO33452.1 - 0.81 10.2 2.9 0.85 10.1 0.6 2.3 2 0 0 2 2 2 0 Proline-rich acidic protein 1, pregnancy-specific uterine ABC1 PF03109.16 KOO33453.1 - 9.3e-24 83.9 0.0 1.9e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO33453.1 - 2.5e-05 24.3 0.3 0.00011 22.2 0.3 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 KOO33453.1 - 0.017 14.7 0.0 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Pkinase PF00069.25 KOO33453.1 - 0.019 14.3 0.0 0.094 12.1 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain WaaY PF06176.11 KOO33453.1 - 0.17 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Galactosyl_T PF01762.21 KOO33454.1 - 7.5e-08 32.4 0.0 1.8e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Galactosyltransferase PAN_1 PF00024.26 KOO33454.1 - 0.0015 18.4 2.1 0.0015 18.4 2.1 2.1 2 0 0 2 2 2 1 PAN domain DUF2527 PF10736.9 KOO33454.1 - 0.036 13.9 2.1 0.44 10.4 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) Glycolytic PF00274.19 KOO33456.1 - 6.2e-112 373.8 0.0 8.1e-112 373.4 0.0 1.1 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Ank PF00023.30 KOO33456.1 - 6.6e-10 39.0 1.7 0.00022 21.5 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 KOO33456.1 - 1.7e-08 34.9 0.1 0.00042 20.8 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO33456.1 - 2.4e-07 30.9 2.9 0.00012 22.3 0.4 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO33456.1 - 4.4e-07 30.3 1.0 1.9e-06 28.3 0.1 2.6 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33456.1 - 4.1e-05 23.7 0.7 0.63 10.8 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat DUF5572 PF17733.1 KOO33456.1 - 0.15 11.9 0.2 0.36 10.7 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5572) Myb_DNA-binding PF00249.31 KOO33457.1 - 1.2e-28 99.0 0.1 1.1e-14 54.3 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO33457.1 - 6.4e-20 71.2 0.0 1.9e-14 53.6 0.0 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 KOO33457.1 - 1.7e-06 28.0 0.0 0.066 13.2 0.0 2.2 1 1 1 2 2 2 2 SLIDE Myb_DNA-bind_4 PF13837.6 KOO33457.1 - 0.19 12.1 0.6 25 5.3 0.3 2.6 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO33457.1 - 0.22 11.4 0.0 0.68 9.9 0.0 1.7 2 0 0 2 2 2 0 Myb DNA-binding like NTP_transferase PF00483.23 KOO33458.1 - 1.9e-36 125.9 0.0 2.4e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 KOO33458.1 - 6.6e-11 42.8 0.0 9.4e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 KOO33458.1 - 7.8e-09 34.9 1.2 7.8e-09 34.9 1.2 3.3 2 1 2 4 4 4 1 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 KOO33458.1 - 0.015 13.5 0.1 0.023 12.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Fucokinase PF07959.12 KOO33458.1 - 0.015 14.3 0.4 0.055 12.4 0.2 1.9 2 1 0 2 2 2 0 L-fucokinase Hexapep_2 PF14602.6 KOO33458.1 - 0.021 14.6 2.3 0.021 14.6 2.3 2.7 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase WD40 PF00400.32 KOO33459.1 - 6.3e-11 42.7 5.2 0.00033 21.4 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat YmzC PF14157.6 KOO33459.1 - 0.0061 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 YmzC-like protein Cytidylate_kin PF02224.18 KOO33460.1 - 0.014 15.2 0.1 0.24 11.1 0.0 2.3 2 1 0 2 2 2 0 Cytidylate kinase SRP54 PF00448.22 KOO33460.1 - 0.031 13.9 0.3 0.08 12.6 0.1 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 KOO33460.1 - 0.087 13.2 1.0 0.16 12.4 0.3 2.0 1 1 1 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 KOO33460.1 - 0.14 11.4 0.1 3.6 6.8 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Rad17 PF03215.15 KOO33460.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Mito_carr PF00153.27 KOO33461.1 - 1.2e-16 60.4 11.9 1e-06 28.5 0.3 3.4 2 1 1 3 3 3 3 Mitochondrial carrier protein Dynein_C PF18199.1 KOO33462.1 - 4e-83 279.2 0.0 1.9e-81 273.7 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain MT PF12777.7 KOO33462.1 - 1.1e-76 258.1 2.2 3.6e-45 154.5 0.1 2.5 2 0 0 2 2 2 2 Microtubule-binding stalk of dynein motor AAA_9 PF12781.7 KOO33462.1 - 2.3e-62 210.0 0.0 8.1e-62 208.2 0.0 2.0 1 1 0 1 1 1 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 KOO33462.1 - 7e-45 152.8 0.0 1.1e-44 152.1 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO33462.1 - 2.7e-32 111.4 0.0 7.2e-32 110.0 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain Spc7 PF08317.11 KOO33462.1 - 0.098 11.5 1.0 0.22 10.4 1.0 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein MazG PF03819.17 KOO33462.1 - 0.19 11.9 0.7 2.9 8.1 0.6 2.6 2 0 0 2 2 2 0 MazG nucleotide pyrophosphohydrolase domain CENP-F_leu_zip PF10473.9 KOO33462.1 - 0.29 11.1 1.2 1.1 9.3 1.2 1.9 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PABP PF00658.18 KOO33463.1 - 1.1e-05 25.5 0.1 2.5e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Methyltransf_21 PF05050.12 KOO33464.1 - 3.8e-11 43.3 0.0 5.2e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_25 PF13649.6 KOO33464.1 - 0.0048 17.6 0.0 0.0086 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO33464.1 - 0.023 14.5 0.0 0.023 14.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Ank_5 PF13857.6 KOO33465.1 - 1.4e-12 47.6 2.1 2.1e-08 34.3 0.4 3.0 2 1 1 3 3 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO33465.1 - 1.6e-12 47.8 3.2 9e-11 42.2 1.8 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) EF-hand_6 PF13405.6 KOO33465.1 - 1.9e-12 46.0 0.2 0.00011 21.9 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO33465.1 - 5.1e-12 44.4 0.2 2.4e-05 23.6 0.1 2.6 2 0 0 2 2 2 2 EF hand Ank_4 PF13637.6 KOO33465.1 - 1.3e-11 44.7 0.1 3.3e-05 24.3 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33465.1 - 5e-10 38.7 0.3 0.002 18.5 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOO33465.1 - 1.1e-08 35.1 0.2 0.00032 21.0 0.1 3.8 3 0 0 3 3 3 1 Ankyrin repeat EF-hand_5 PF13202.6 KOO33465.1 - 1.4e-08 33.9 1.4 5.8e-05 22.4 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO33465.1 - 1.7e-08 34.8 0.1 5.6e-08 33.1 0.1 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO33465.1 - 5e-08 32.7 0.1 6.8e-06 25.8 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair ADPrib_exo_Tox PF03496.14 KOO33465.1 - 5e-06 26.0 0.0 2.4e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO33465.1 - 0.002 17.4 0.0 0.0051 16.1 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_6 PF13516.6 KOO33465.1 - 0.0021 18.0 0.0 0.006 16.5 0.0 1.9 1 0 0 1 1 1 1 Leucine Rich repeat Ferritin PF00210.24 KOO33465.1 - 0.065 13.2 0.4 1.6 8.7 0.2 2.5 2 0 0 2 2 2 0 Ferritin-like domain LRR_6 PF13516.6 KOO33466.1 - 1.2e-33 112.3 64.2 0.00047 20.0 0.2 22.6 23 0 0 23 23 23 9 Leucine Rich repeat LRR_4 PF12799.7 KOO33466.1 - 5.3e-11 42.6 34.3 0.51 10.9 0.0 13.7 13 1 1 14 14 14 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO33466.1 - 1.2e-05 25.2 17.5 1.3e+02 3.8 0.3 12.7 16 0 0 16 16 16 0 Leucine Rich Repeat SpoU_sub_bind PF08032.12 KOO33466.1 - 0.00093 19.4 2.5 22 5.4 0.0 7.2 8 0 0 8 8 8 0 RNA 2'-O ribose methyltransferase substrate binding YusW PF14039.6 KOO33466.1 - 0.013 16.0 2.1 2.2e+02 2.4 0.0 6.4 6 1 1 7 7 7 0 YusW-like protein DUF2202 PF09968.9 KOO33466.1 - 0.018 14.9 10.4 22 4.8 0.0 6.3 6 1 1 7 7 7 0 Uncharacterized protein domain (DUF2202) LRR_8 PF13855.6 KOO33466.1 - 0.026 14.3 39.1 20 5.1 0.9 13.2 11 4 2 13 13 13 0 Leucine rich repeat EpsG PF14897.6 KOO33466.1 - 0.12 11.6 2.6 0.21 10.9 2.6 1.3 1 0 0 1 1 1 0 EpsG family DUF445 PF04286.12 KOO33466.1 - 1.2 8.9 8.9 4.9 6.9 2.0 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF445) Helicase_C PF00271.31 KOO33467.1 - 0.00027 21.2 0.0 0.00048 20.5 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KOO33468.1 - 1.3e-11 43.8 0.0 1.9e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain DNA_methylase PF00145.17 KOO33468.1 - 1.7e-06 27.6 0.0 0.049 13.0 0.0 2.4 2 1 0 2 2 2 2 C-5 cytosine-specific DNA methylase ResIII PF04851.15 KOO33468.1 - 0.041 13.9 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit FYVE_2 PF02318.16 KOO33468.1 - 7 6.9 9.6 14 6.0 9.6 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Roughex PF06020.11 KOO33469.1 - 0.036 13.2 0.9 0.041 13.0 0.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein PDZ PF00595.24 KOO33470.1 - 5.6e-17 61.9 1.6 1.4e-07 31.7 0.3 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KOO33470.1 - 9.6e-17 60.6 1.1 2.2e-07 30.6 0.1 2.8 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 KOO33470.1 - 3.1e-16 59.4 2.1 6.7e-08 32.8 0.2 2.5 2 0 0 2 2 2 2 PDZ domain FAIM1 PF06905.13 KOO33470.1 - 3.4e-08 33.4 0.0 5.9e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Fas apoptotic inhibitory molecule (FAIM1) Tricorn_PDZ PF14685.6 KOO33470.1 - 0.0018 18.2 0.4 2 8.4 0.1 3.1 3 0 0 3 3 3 2 Tricorn protease PDZ domain PT-HINT PF07591.11 KOO33470.1 - 0.12 12.6 0.0 1.1 9.6 0.0 2.2 2 0 0 2 2 2 0 Pretoxin HINT domain BLOC1_2 PF10046.9 KOO33471.1 - 0.17 12.2 3.8 0.28 11.5 2.5 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Arg_decarbox_C PF17944.1 KOO33471.1 - 1.5 9.4 6.3 0.49 11.0 0.7 3.0 3 0 0 3 3 3 0 Arginine decarboxylase C-terminal helical extension PI3K_P85_iSH2 PF16454.5 KOO33471.1 - 1.6 8.3 3.8 2.1 7.9 0.5 2.3 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain AAA_13 PF13166.6 KOO33471.1 - 4.4 5.8 8.4 26 3.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain UPF0242 PF06785.11 KOO33471.1 - 6.8 6.7 5.7 11 6.0 0.7 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Methyltr_RsmB-F PF01189.17 KOO33472.1 - 1.9e-20 73.3 0.0 7.6e-20 71.4 0.0 1.9 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KOO33472.1 - 0.0034 17.5 0.0 0.0061 16.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Amino_oxidase PF01593.24 KOO33474.1 - 4.8e-15 55.8 0.0 1.1e-14 54.5 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO33474.1 - 1.2e-12 47.9 0.1 3.4e-12 46.4 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO33474.1 - 9.6e-08 31.5 0.5 6.3e-05 22.2 0.4 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 KOO33474.1 - 3.7e-07 30.1 0.2 0.012 15.3 0.0 2.7 2 1 0 2 2 2 2 FAD dependent oxidoreductase GDI PF00996.18 KOO33474.1 - 4.7e-06 25.4 0.3 0.0043 15.6 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor Pyr_redox_2 PF07992.14 KOO33474.1 - 5.6e-06 25.8 1.6 0.015 14.5 0.3 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOO33474.1 - 4.7e-05 22.8 0.5 9.1e-05 21.8 0.1 1.6 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 KOO33474.1 - 0.00032 19.5 0.6 0.032 13.0 0.3 2.3 2 0 0 2 2 2 2 HI0933-like protein FAD_oxidored PF12831.7 KOO33474.1 - 0.0052 16.2 0.7 0.014 14.8 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOO33474.1 - 0.0069 16.9 0.8 0.55 10.8 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 KOO33474.1 - 0.0097 15.3 0.1 0.033 13.6 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_3 PF01494.19 KOO33474.1 - 0.034 13.4 0.4 0.055 12.7 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 KOO33474.1 - 0.041 13.0 0.3 2.2 7.3 0.2 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A UPF0227 PF05728.12 KOO33474.1 - 0.067 13.1 0.0 0.26 11.2 0.0 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Pyr_redox_3 PF13738.6 KOO33474.1 - 0.088 12.1 0.1 0.17 11.1 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase zf-RanBP PF00641.18 KOO33476.1 - 5.9e-05 22.3 1.5 0.00011 21.4 1.5 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Peptidase_S49 PF01343.18 KOO33477.1 - 1.2e-31 109.7 0.0 2e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S49 Peptidase_S49_N PF08496.10 KOO33477.1 - 1.3e-14 54.6 0.1 7.5e-14 52.1 0.1 2.0 1 1 0 1 1 1 1 Peptidase family S49 N-terminal SDH_sah PF01972.16 KOO33477.1 - 0.0022 17.0 0.2 0.0034 16.4 0.2 1.2 1 0 0 1 1 1 1 Serine dehydrogenase proteinase CLP_protease PF00574.23 KOO33477.1 - 0.036 13.9 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Clp protease RmlD_sub_bind PF04321.17 KOO33478.1 - 2e-56 191.2 0.0 2.4e-56 191.0 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 KOO33478.1 - 2.4e-11 43.6 0.0 3.2e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KOO33478.1 - 0.0011 18.2 0.1 0.57 9.3 0.0 2.3 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 KOO33478.1 - 0.016 14.6 0.0 0.03 13.7 0.0 1.5 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase GST_N PF02798.20 KOO33479.1 - 2.4e-12 47.0 0.0 4.5e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOO33479.1 - 4.5e-08 33.2 0.0 1.1e-07 31.9 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOO33479.1 - 4.1e-05 23.5 1.1 7.9e-05 22.6 0.2 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOO33479.1 - 0.0091 16.4 0.0 0.019 15.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Ion_trans_2 PF07885.16 KOO33481.1 - 3.7e-06 26.8 1.5 3.7e-06 26.8 1.5 2.1 2 0 0 2 2 2 1 Ion channel Peptidase_U4 PF03419.13 KOO33481.1 - 0.038 13.3 1.7 0.062 12.6 1.7 1.3 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Nuc_sug_transp PF04142.15 KOO33482.1 - 1.4e-07 31.0 4.6 2.8e-07 30.0 4.6 1.4 1 1 0 1 1 1 1 Nucleotide-sugar transporter CRT-like PF08627.10 KOO33482.1 - 1.8e-06 27.2 1.5 1.8e-06 27.2 1.5 1.5 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 KOO33482.1 - 0.00022 20.7 4.5 0.00046 19.6 4.5 1.7 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO33482.1 - 0.0013 18.9 8.1 0.0013 18.9 8.1 3.7 4 1 0 4 4 4 1 EamA-like transporter family Phage_holin_2_3 PF16080.5 KOO33482.1 - 0.97 9.2 0.0 0.97 9.2 0.0 4.0 6 0 0 6 6 6 0 Bacteriophage holin family HP1 WD40 PF00400.32 KOO33486.1 - 4.5e-20 71.6 3.7 0.00025 21.7 0.8 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO33486.1 - 1.3e-06 28.6 0.0 0.00035 20.8 0.0 3.6 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO33486.1 - 6.6e-05 22.0 0.0 0.24 10.3 0.0 2.5 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein EF-hand_7 PF13499.6 KOO33488.1 - 0.00019 21.8 0.2 0.00056 20.3 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO33488.1 - 0.0011 18.7 0.2 0.0048 16.7 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO33488.1 - 0.002 17.5 0.1 0.016 14.7 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO33488.1 - 0.062 12.8 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 EF hand Stn1 PF10451.9 KOO33489.1 - 3e-06 26.4 0.0 4.5e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.25 KOO33489.1 - 0.0025 17.7 0.0 0.005 16.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain MP PF01107.18 KOO33489.1 - 0.28 10.7 0.0 0.4 10.2 0.0 1.1 1 0 0 1 1 1 0 Viral movement protein (MP) PDEase_I PF00233.19 KOO33490.1 - 3.2e-15 56.5 0.0 4.2e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Melibiase_2 PF16499.5 KOO33491.1 - 3.4e-64 216.8 2.3 5.9e-64 216.0 2.3 1.4 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 KOO33491.1 - 1.2e-16 60.5 0.0 7.4e-16 58.0 0.0 2.2 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 KOO33491.1 - 4.5e-05 22.6 0.0 0.00015 20.8 0.0 1.8 3 0 0 3 3 3 1 Melibiase Melibiase_2_C PF17450.2 KOO33491.1 - 0.088 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Alpha galactosidase A C-terminal beta sandwich domain EF-hand_6 PF13405.6 KOO33492.1 - 3.5e-11 42.1 2.1 5.3e-05 22.8 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO33492.1 - 3e-09 35.8 2.5 0.00024 20.4 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO33492.1 - 6.8e-09 36.0 0.7 1.3e-08 35.1 0.3 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO33492.1 - 3.3e-08 33.2 0.5 3.2e-07 30.1 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair IQ PF00612.27 KOO33492.1 - 5.8e-06 25.6 5.9 0.038 13.8 2.8 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif EF-hand_5 PF13202.6 KOO33492.1 - 1.5e-05 24.3 1.9 0.044 13.3 0.1 2.4 2 0 0 2 2 2 2 EF hand Mpp10 PF04006.12 KOO33495.1 - 2e-69 234.7 20.1 2.8e-69 234.2 20.1 1.2 1 0 0 1 1 1 1 Mpp10 protein FAST_2 PF08368.12 KOO33495.1 - 0.16 12.8 0.1 0.52 11.1 0.1 1.9 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 2 Pro-NT_NN PF07421.11 KOO33495.1 - 2.7 8.2 6.1 0.24 11.7 1.1 1.8 2 0 0 2 2 2 0 Neurotensin/neuromedin N precursor HTH_ABP1_N PF18107.1 KOO33495.1 - 2.9 7.7 5.1 23 4.8 2.8 2.6 1 1 1 2 2 2 0 Fission yeast centromere protein N-terminal domain Metallophos PF00149.28 KOO33496.1 - 8.5e-34 117.8 0.2 1.3e-33 117.2 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 KOO33496.1 - 3.3e-19 69.0 0.0 7.4e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 KOO33496.1 - 7.5e-17 60.4 7.2 9e-08 31.6 0.4 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO33496.1 - 1.2e-13 50.5 0.2 1.3e-06 28.0 0.0 3.6 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.17 KOO33496.1 - 2.2e-13 49.2 12.0 6.7e-07 29.0 0.4 4.5 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO33496.1 - 1.9e-07 31.6 0.7 0.0051 17.4 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO33496.1 - 5.3e-07 29.3 4.2 0.0012 18.9 0.4 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO33496.1 - 5.4e-07 29.6 4.1 0.0074 16.6 0.1 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO33496.1 - 7e-07 29.3 0.3 0.051 13.7 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO33496.1 - 6.6e-06 26.5 1.5 0.0064 17.2 0.4 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO33496.1 - 0.00018 21.7 0.2 0.19 12.0 0.0 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO33496.1 - 0.0013 18.6 0.2 0.87 9.8 0.1 3.1 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOO33496.1 - 0.016 15.8 1.3 0.18 12.5 0.4 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO33496.1 - 0.074 13.6 1.1 1.7 9.2 0.2 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat Paf67 PF10255.9 KOO33496.1 - 0.12 11.3 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 NAD_kinase PF01513.21 KOO33498.1 - 0.0034 16.6 0.0 0.0056 15.9 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 KOO33498.1 - 0.0037 16.9 0.1 0.014 15.0 0.0 2.0 2 1 0 2 2 2 1 Diacylglycerol kinase catalytic domain cwf21 PF08312.12 KOO33498.1 - 0.061 13.5 0.8 7.1 6.9 0.0 2.4 2 0 0 2 2 2 0 cwf21 domain CENP-F_leu_zip PF10473.9 KOO33498.1 - 0.067 13.2 0.9 0.11 12.6 0.9 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4164 PF13747.6 KOO33498.1 - 0.094 13.0 3.5 0.18 12.1 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Pkinase PF00069.25 KOO33499.1 - 5.9e-48 163.5 0.0 8.5e-48 163.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33499.1 - 8.7e-41 139.9 0.0 1.2e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO33499.1 - 0.28 11.1 0.3 0.52 10.2 0.3 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-H2C2_2 PF13465.6 KOO33500.1 - 6.3e-29 99.1 59.0 5.2e-06 26.7 1.3 7.5 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.26 KOO33500.1 - 4.2e-28 96.2 58.8 0.00012 22.4 2.8 7.2 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOO33500.1 - 3.7e-18 64.6 51.9 0.0043 17.8 1.7 7.2 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KOO33500.1 - 1e-05 25.7 20.8 0.028 14.7 6.7 3.6 1 1 2 3 3 3 3 C2H2-type zinc ribbon CHORD PF04968.12 KOO33500.1 - 8.8e-05 23.2 43.5 2.8 8.7 1.1 7.1 2 2 5 7 7 7 6 CHORD Arm PF00514.23 KOO33500.1 - 0.019 15.0 0.1 0.019 15.0 0.1 1.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat zf-met PF12874.7 KOO33500.1 - 0.099 13.1 16.3 11 6.6 0.1 6.0 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOO33500.1 - 0.24 11.7 23.2 12 6.3 0.7 6.4 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 KOO33500.1 - 0.76 9.9 23.7 15 5.7 0.2 6.6 1 1 6 7 7 7 0 Aberrant zinc-finger FRG2 PF15315.6 KOO33500.1 - 6 7.0 17.7 3 8.0 6.1 3.1 1 1 2 3 3 3 0 Facioscapulohumeral muscular dystrophy candidate 2 ASD2 PF08687.11 KOO33501.1 - 0.59 9.7 26.5 1.3 8.5 1.8 2.3 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 PRTase_3 PF15610.6 KOO33502.1 - 9.4e-09 34.9 0.0 2.5e-08 33.5 0.0 1.6 2 0 0 2 2 2 1 PRTase ComF-like zf-RING_11 PF17123.5 KOO33502.1 - 0.071 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 RING-like zinc finger Syntaxin_2 PF14523.6 KOO33503.1 - 2.6e-10 40.6 6.5 1.3e-09 38.3 0.2 2.3 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 KOO33503.1 - 3.2e-09 36.7 0.1 8.4e-09 35.3 0.1 1.8 1 0 0 1 1 1 1 SNARE domain MCPsignal PF00015.21 KOO33503.1 - 8.8e-06 25.6 2.6 1.1e-05 25.3 2.6 1.3 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Syntaxin PF00804.25 KOO33503.1 - 7.5e-05 22.5 9.2 0.0013 18.5 0.6 2.9 1 1 2 3 3 3 2 Syntaxin Allexi_40kDa PF05549.11 KOO33503.1 - 0.00044 19.9 0.6 0.00058 19.5 0.6 1.1 1 0 0 1 1 1 1 Allexivirus 40kDa protein Laminin_II PF06009.12 KOO33503.1 - 0.00073 19.6 2.8 0.00073 19.6 2.8 2.1 2 0 0 2 2 2 1 Laminin Domain II Prominin PF05478.11 KOO33503.1 - 0.0057 14.7 0.3 0.0066 14.5 0.3 1.2 1 0 0 1 1 1 1 Prominin DUF948 PF06103.11 KOO33503.1 - 0.012 15.8 2.0 0.012 15.8 2.0 2.4 2 1 1 3 3 2 0 Bacterial protein of unknown function (DUF948) AIP3 PF03915.13 KOO33503.1 - 0.02 14.0 5.8 0.024 13.8 5.8 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 DUF148 PF02520.17 KOO33503.1 - 0.052 13.6 6.1 0.087 12.9 6.1 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 Peptidase_M29 PF02073.15 KOO33503.1 - 0.064 12.0 1.2 0.084 11.6 1.2 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) DUF3112 PF11309.8 KOO33503.1 - 0.12 11.8 0.9 0.15 11.5 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Exonuc_VII_L PF02601.15 KOO33503.1 - 0.12 11.9 4.0 0.15 11.6 4.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2605 PF10792.9 KOO33503.1 - 0.16 11.9 1.8 0.23 11.4 1.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2605) SKA1 PF07160.12 KOO33503.1 - 0.26 11.1 5.8 0.35 10.7 4.6 1.7 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 T2SSF PF00482.23 KOO33503.1 - 0.39 10.7 3.6 1 9.4 3.6 2.0 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F LPP PF04728.13 KOO33503.1 - 0.41 11.1 4.6 1.1 9.7 1.2 2.5 1 1 1 2 2 2 0 Lipoprotein leucine-zipper Ax_dynein_light PF10211.9 KOO33503.1 - 0.52 10.2 9.3 0.77 9.7 9.3 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain DUF883 PF05957.13 KOO33503.1 - 0.71 10.5 7.5 4.2 8.0 1.1 2.4 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) MCU PF04678.13 KOO33503.1 - 0.74 9.9 4.8 2 8.5 4.8 1.7 1 1 0 1 1 1 0 Mitochondrial calcium uniporter KxDL PF10241.9 KOO33503.1 - 0.85 9.9 10.2 0.33 11.3 5.0 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein PIN_8 PF18476.1 KOO33503.1 - 0.98 9.2 5.1 1.3 8.8 5.1 1.2 1 0 0 1 1 1 0 PIN like domain DUF16 PF01519.16 KOO33503.1 - 1.2 9.6 4.8 7.8 7.0 2.8 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 THOC7 PF05615.13 KOO33503.1 - 3.1 8.1 12.7 5.5 7.3 12.5 1.4 1 1 0 1 1 1 0 Tho complex subunit 7 CENP-H PF05837.12 KOO33503.1 - 3.4 8.1 11.7 1.4 9.4 1.3 2.5 2 1 0 2 2 2 0 Centromere protein H (CENP-H) TMPIT PF07851.13 KOO33503.1 - 3.7 6.7 6.8 0.89 8.7 1.1 1.8 1 1 1 2 2 2 0 TMPIT-like protein SlyX PF04102.12 KOO33503.1 - 7.4 7.3 7.8 29 5.4 1.2 2.5 1 1 1 2 2 2 0 SlyX PNTB PF02233.16 KOO33504.1 - 8.7e-172 572.2 17.2 8.7e-172 572.2 17.2 2.1 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 KOO33504.1 - 3.2e-65 219.4 3.1 1.3e-64 217.4 3.1 2.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ParA PF10609.9 KOO33504.1 - 8.1e-47 159.7 0.0 2.4e-45 154.9 0.0 2.8 2 1 1 3 3 3 1 NUBPL iron-transfer P-loop NTPase AlaDh_PNT_N PF05222.15 KOO33504.1 - 4.1e-33 114.6 0.0 9.5e-33 113.4 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 KOO33504.1 - 3.2e-28 98.0 5.6 3.2e-28 98.0 5.6 4.2 4 0 0 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch Pyr_redox_2 PF07992.14 KOO33504.1 - 0.0022 17.3 1.9 0.018 14.3 0.3 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOO33504.1 - 0.023 13.8 0.9 0.05 12.7 0.9 1.6 1 0 0 1 1 1 0 Glucose inhibited division protein A TPP_enzyme_M PF00205.22 KOO33504.1 - 0.031 14.0 0.1 0.14 11.9 0.1 2.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain 2-Hacid_dh_C PF02826.19 KOO33504.1 - 0.047 13.1 0.4 1 8.7 0.2 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 KOO33504.1 - 0.057 13.4 5.8 0.096 12.7 0.6 3.6 3 0 0 3 3 3 0 Zinc-binding dehydrogenase Pyr_redox PF00070.27 KOO33504.1 - 0.27 11.8 3.4 1.1 9.9 0.5 3.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase RseC_MucC PF04246.12 KOO33504.1 - 1.5 8.8 7.6 7.9 6.4 0.1 3.7 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC WD40 PF00400.32 KOO33505.1 - 6.4e-35 118.6 21.9 5.2e-06 27.1 0.7 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO33505.1 - 2.3e-21 75.9 1.9 0.00029 21.1 0.0 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO33505.1 - 1.1e-05 25.4 0.4 0.14 12.0 0.0 3.1 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A LRR_6 PF13516.6 KOO33506.1 - 1.2e-09 37.5 22.8 0.00046 20.0 0.1 7.8 10 0 0 10 10 10 5 Leucine Rich repeat LRR_8 PF13855.6 KOO33506.1 - 3.1e-08 33.3 0.1 5.2 6.9 0.0 5.4 5 1 0 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 KOO33506.1 - 7.3e-08 31.9 0.5 19 6.3 0.0 5.8 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_4 PF12799.7 KOO33506.1 - 3.4e-05 24.1 5.7 10 6.7 0.8 5.4 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) UPF0181 PF03701.14 KOO33506.1 - 0.0054 16.3 0.2 16 5.2 0.1 3.5 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0181) Herpes_TK_C PF08465.10 KOO33506.1 - 0.11 12.2 0.9 2.4 8.0 0.1 2.8 3 0 0 3 3 3 0 Thymidine kinase from Herpesvirus C-terminal PCP PF02429.15 KOO33506.1 - 0.59 10.4 5.6 17 5.7 0.1 4.1 2 1 2 5 5 5 0 Peridinin-chlorophyll A binding protein Skp1 PF01466.19 KOO33507.1 - 0.0046 17.0 0.0 0.0099 16.0 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Ank_2 PF12796.7 KOO33508.1 - 9.3e-21 74.2 0.0 3e-06 27.7 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO33508.1 - 3.3e-18 63.9 0.3 0.0025 18.2 0.0 6.4 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 KOO33508.1 - 1.2e-16 60.6 3.5 0.00056 20.2 0.0 5.9 3 1 3 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO33508.1 - 2.8e-15 56.0 4.7 0.0012 19.2 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 KOO33508.1 - 2.6e-12 47.0 0.6 0.00045 20.7 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeats (many copies) ParG PF09274.10 KOO33508.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 ParG LRR_6 PF13516.6 KOO33509.1 - 3.4e-15 54.7 0.2 3.4e-05 23.6 0.0 3.4 3 0 0 3 3 3 3 Leucine Rich repeat HOASN PF14515.6 KOO33509.1 - 0.0034 17.7 2.0 0.73 10.3 0.6 2.4 1 1 1 2 2 2 2 Haem-oxygenase-associated N-terminal helices LRR_8 PF13855.6 KOO33509.1 - 0.13 12.0 0.3 3 7.7 0.1 2.7 2 1 0 2 2 2 0 Leucine rich repeat LRR_4 PF12799.7 KOO33509.1 - 0.14 12.6 0.1 0.94 10.0 0.1 2.3 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO33509.1 - 0.15 12.7 0.0 44 5.2 0.0 2.9 3 0 0 3 3 3 0 Leucine Rich Repeat KAsynt_C_assoc PF16197.5 KOO33510.1 - 0.058 13.8 0.0 0.068 13.6 0.0 1.1 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension DUF3431 PF11913.8 KOO33511.1 - 1.1e-08 35.1 0.1 1.8e-07 31.2 0.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) PH_TFIIH PF08567.11 KOO33512.1 - 8.4e-11 42.1 0.0 1.3e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 KOO33512.1 - 1.5e-08 34.5 0.1 2.7e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 BSD domain UbiA PF01040.18 KOO33513.1 - 1e-33 116.7 24.3 1.4e-33 116.3 24.3 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Cation_efflux PF01545.21 KOO33515.1 - 5.6e-05 23.0 3.7 7.9e-05 22.5 3.7 1.4 1 1 0 1 1 1 1 Cation efflux family Tetraspanin PF00335.20 KOO33515.1 - 0.18 11.5 2.0 0.28 10.9 2.0 1.3 1 0 0 1 1 1 0 Tetraspanin family Glyco_hydro_18 PF00704.28 KOO33516.1 - 2.2e-34 119.6 0.0 2.6e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Herpes_LMP1 PF05297.11 KOO33516.1 - 3.9 6.6 5.0 5.4 6.1 5.0 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) SNF2_N PF00176.23 KOO33517.1 - 1.7e-31 109.3 3.4 2.5e-24 85.6 0.0 3.0 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO33517.1 - 5.2e-14 52.5 0.0 1.6e-13 51.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.29 KOO33517.1 - 0.00011 22.0 6.4 0.00011 22.0 6.4 3.1 3 0 0 3 3 3 2 PHD-finger AAA_22 PF13401.6 KOO33517.1 - 0.014 15.7 1.2 0.094 13.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 KOO33517.1 - 0.032 14.2 0.0 0.032 14.2 0.0 2.8 3 2 1 4 4 4 0 Type III restriction enzyme, res subunit Atg14 PF10186.9 KOO33517.1 - 3.8 6.5 19.2 7.7 5.5 19.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_12 PF13424.6 KOO33518.1 - 5.1e-67 222.1 45.2 3e-15 56.3 0.5 8.8 2 1 6 9 9 9 7 Tetratricopeptide repeat TPR_10 PF13374.6 KOO33518.1 - 2.3e-64 211.6 43.6 5.1e-12 45.3 0.2 10.2 10 1 0 10 10 9 8 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO33518.1 - 2.5e-22 79.7 24.9 7.1e-11 42.1 4.2 3.6 1 1 2 3 3 3 3 MalT-like TPR region TPR_8 PF13181.6 KOO33518.1 - 2.2e-19 68.0 9.0 0.14 12.5 0.0 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33518.1 - 2.5e-19 68.2 16.5 0.014 15.2 0.0 7.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO33518.1 - 9.3e-18 62.9 21.2 0.016 15.3 0.1 8.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_4 PF07721.14 KOO33518.1 - 2.8e-12 46.0 38.3 0.022 15.4 0.3 10.4 10 0 0 10 10 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOO33518.1 - 4.2e-10 39.3 5.7 3.8 8.1 0.0 7.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO33518.1 - 1e-09 37.7 29.3 0.013 15.4 0.1 7.7 9 0 0 9 9 7 5 Tetratricopeptide repeat TPR_3 PF07720.12 KOO33518.1 - 1.4e-06 28.2 0.2 0.1 12.6 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO33518.1 - 2.9e-06 27.7 29.7 0.027 15.0 0.2 6.7 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOO33518.1 - 2.5e-05 23.9 16.5 5.2 6.8 0.0 7.9 8 0 0 8 8 8 1 TPR repeat TPR_16 PF13432.6 KOO33518.1 - 2.6e-05 24.7 56.6 0.028 15.1 3.5 9.8 6 4 1 7 7 6 4 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO33518.1 - 0.0019 18.4 10.6 2.9 8.2 0.1 6.2 8 0 0 8 8 7 2 Osmosensory transporter coiled coil V-SNARE_C PF12352.8 KOO33518.1 - 0.035 14.4 0.1 3.5 8.0 0.0 3.0 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Sec16_C PF12931.7 KOO33518.1 - 0.046 13.4 1.1 45 3.6 0.1 4.0 2 2 2 4 4 4 0 Sec23-binding domain of Sec16 DUF2806 PF10987.8 KOO33518.1 - 0.16 11.9 0.2 2.1 8.2 0.1 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2806) PPR PF01535.20 KOO33518.1 - 0.18 12.1 8.2 33 5.0 0.1 5.8 7 0 0 7 7 6 0 PPR repeat TPR_14 PF13428.6 KOO33518.1 - 0.18 12.7 45.6 2 9.5 0.1 10.7 11 0 0 11 11 9 0 Tetratricopeptide repeat FYRN PF05964.14 KOO33518.1 - 0.24 11.3 0.5 41 4.1 0.0 4.1 5 0 0 5 5 5 0 F/Y-rich N-terminus Calpain_inhib PF00748.19 KOO33518.1 - 0.76 10.3 3.1 1.7 9.1 0.6 2.7 4 0 0 4 4 2 0 Calpain inhibitor PPR_1 PF12854.7 KOO33518.1 - 7.6 6.3 7.3 35 4.2 0.1 4.5 5 0 0 5 5 5 0 PPR repeat Amino_oxidase PF01593.24 KOO33521.1 - 0.063 12.6 0.4 4 6.6 0.2 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase GDA1_CD39 PF01150.17 KOO33522.1 - 2.2e-24 85.9 0.0 2.4e-24 85.8 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF2341 PF10102.9 KOO33523.1 - 0.22 12.1 0.0 1.5 9.5 0.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF2341) IQ PF00612.27 KOO33524.1 - 0.0017 17.9 0.0 0.0067 16.1 0.0 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif RVT_3 PF13456.6 KOO33524.1 - 0.12 12.2 0.3 8.6 6.2 0.0 2.4 2 0 0 2 2 2 0 Reverse transcriptase-like RNA_pol_L_2 PF13656.6 KOO33525.1 - 6.1e-25 86.8 0.0 7.4e-25 86.5 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KOO33525.1 - 1.6e-07 30.7 0.0 2.2e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain adh_short PF00106.25 KOO33526.1 - 4.4e-27 94.8 4.6 2e-24 86.1 0.6 2.4 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO33526.1 - 2.3e-13 50.2 7.8 4.9e-13 49.2 1.5 2.4 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO33526.1 - 1.1e-05 25.4 0.9 2.3e-05 24.4 0.9 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOO33526.1 - 0.025 14.0 0.1 0.074 12.5 0.1 1.8 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family SbmA_BacA PF05992.12 KOO33527.1 - 4.9e-44 151.0 0.0 5.6e-44 150.8 0.0 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.15 KOO33527.1 - 2.5e-08 33.7 0.0 9.4e-08 31.8 0.0 1.9 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 Sulfotransfer_4 PF17784.1 KOO33528.1 - 7.7e-08 32.4 0.2 1.1e-05 25.3 0.0 2.0 1 1 1 2 2 2 2 Sulfotransferase domain eIF-5_eIF-2B PF01873.17 KOO33529.1 - 1.4e-27 95.9 0.0 1.3e-26 92.8 0.0 2.1 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.18 KOO33529.1 - 1.4e-20 73.2 1.4 1.4e-20 73.2 1.4 2.8 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon CHASE8 PF17152.4 KOO33529.1 - 0.0029 17.8 0.2 0.0081 16.4 0.2 1.7 1 0 0 1 1 1 1 Periplasmic sensor domain Paramyx_P_V_C PF03210.13 KOO33529.1 - 0.012 15.4 0.6 0.021 14.6 0.6 1.3 1 0 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal Sec6 PF06046.13 KOO33530.1 - 1.3e-13 50.2 0.0 1.8e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 CDP-OH_P_transf PF01066.21 KOO33530.1 - 0.02 15.6 0.0 0.055 14.2 0.0 1.8 1 0 0 1 1 1 0 CDP-alcohol phosphatidyltransferase PAP_fibrillin PF04755.12 KOO33531.1 - 3.5e-18 66.3 0.0 1.1e-17 64.6 0.0 1.8 1 1 0 1 1 1 1 PAP_fibrillin Abhydrolase_6 PF12697.7 KOO33531.1 - 0.00027 21.6 6.6 0.00027 21.6 6.6 2.5 1 1 1 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 KOO33531.1 - 0.00078 19.2 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 KOO33531.1 - 0.0035 17.2 0.0 0.0053 16.6 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 KOO33531.1 - 0.011 15.3 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF900 PF05990.12 KOO33531.1 - 0.014 14.9 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.15 KOO33531.1 - 0.018 14.2 0.0 0.035 13.3 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 KOO33531.1 - 0.02 14.1 0.0 0.047 13.0 0.0 1.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 ATP-synt_Eps PF04627.13 KOO33531.1 - 0.046 13.7 0.0 0.098 12.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ATP synthase epsilon chain Abhydrolase_1 PF00561.20 KOO33531.1 - 0.095 12.3 0.0 0.2 11.3 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold CAP_N PF01213.19 KOO33531.1 - 1.4 8.3 2.7 2.2 7.7 2.7 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF309 PF03745.14 KOO33532.1 - 0.097 12.4 0.6 3.9 7.2 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF309) Arm PF00514.23 KOO33533.1 - 3.4e-34 115.8 30.4 7.8e-06 25.7 0.2 7.1 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KOO33533.1 - 7e-09 35.9 0.0 0.087 12.9 0.0 3.7 1 1 3 4 4 4 4 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.13 KOO33533.1 - 0.0059 16.1 0.0 40 3.6 0.0 4.1 1 1 2 4 4 4 1 Armadillo-like DUF3247 PF11607.8 KOO33533.1 - 0.19 12.0 0.0 41 4.5 0.0 3.7 2 2 3 5 5 5 0 Protein of unknown function (DUF3247) ABC_membrane PF00664.23 KOO33534.1 - 3e-50 171.4 14.2 1.3e-29 103.8 5.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOO33534.1 - 4.2e-45 153.6 0.0 1e-24 87.6 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOO33534.1 - 1.6e-10 40.8 0.0 0.0058 16.1 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO33534.1 - 6.6e-08 33.1 0.8 0.00071 20.0 0.0 3.0 3 0 0 3 3 2 2 AAA ATPase domain AAA_29 PF13555.6 KOO33534.1 - 5e-07 29.4 0.0 0.0015 18.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOO33534.1 - 3.5e-06 27.0 0.0 0.017 15.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 KOO33534.1 - 4.5e-06 27.3 0.0 0.00038 21.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KOO33534.1 - 6.6e-06 26.2 0.7 0.07 13.2 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 KOO33534.1 - 4.2e-05 23.5 0.2 0.0049 16.7 0.1 3.1 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 KOO33534.1 - 0.00043 19.9 0.1 0.085 12.4 0.1 2.6 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KOO33534.1 - 0.00047 19.3 0.1 0.014 14.5 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 KOO33534.1 - 0.00059 20.1 1.0 0.11 12.7 0.1 2.9 2 1 0 2 2 2 1 AAA domain DUF87 PF01935.17 KOO33534.1 - 0.00062 19.9 0.7 0.55 10.3 0.2 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_27 PF13514.6 KOO33534.1 - 0.0028 17.3 0.0 0.019 14.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain Adeno_IVa2 PF02456.15 KOO33534.1 - 0.0049 15.7 0.1 0.055 12.3 0.0 2.0 2 0 0 2 2 2 1 Adenovirus IVa2 protein IstB_IS21 PF01695.17 KOO33534.1 - 0.005 16.6 0.4 2.4 7.9 0.0 3.4 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_30 PF13604.6 KOO33534.1 - 0.0082 15.9 2.1 0.64 9.7 0.0 2.9 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KOO33534.1 - 0.013 15.9 0.0 2.7 8.4 0.0 2.8 3 0 0 3 3 2 0 RNA helicase AAA_7 PF12775.7 KOO33534.1 - 0.016 14.7 0.1 1 8.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase_2 PF01637.18 KOO33534.1 - 0.018 15.0 0.0 0.049 13.5 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Dynamin_N PF00350.23 KOO33534.1 - 0.033 14.2 1.9 1.7 8.7 0.0 2.5 2 0 0 2 2 2 0 Dynamin family cobW PF02492.19 KOO33534.1 - 0.034 13.7 0.8 0.12 12.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 KOO33534.1 - 0.037 13.2 0.1 6.3 5.9 0.0 3.1 3 1 0 3 3 3 0 NB-ARC domain AAA_18 PF13238.6 KOO33534.1 - 0.046 14.3 0.2 5.9 7.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KOO33534.1 - 0.051 12.9 0.6 10 5.3 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin ABC_ATPase PF09818.9 KOO33534.1 - 0.051 12.4 0.8 3.8 6.2 0.1 2.9 3 0 0 3 3 3 0 Predicted ATPase of the ABC class FtsK_SpoIIIE PF01580.18 KOO33534.1 - 0.077 12.3 0.1 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family MeaB PF03308.16 KOO33534.1 - 0.12 11.3 0.5 1.1 8.1 0.1 2.5 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 KOO33534.1 - 0.15 12.5 0.1 3.7 8.0 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KOO33534.1 - 0.15 12.2 0.8 1 9.5 0.1 2.4 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 KOO33534.1 - 0.17 11.6 1.2 3.5 7.3 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 KOO33534.1 - 0.21 11.3 0.1 3 7.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 KOO33534.1 - 0.23 10.7 0.9 4.4 6.4 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Form_Nir_trans PF01226.17 KOO33535.1 - 1.8e-25 89.7 6.9 1.9e-25 89.6 6.9 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter Yip1 PF04893.17 KOO33535.1 - 0.76 9.5 14.2 1.4 8.6 14.0 1.5 1 1 0 1 1 1 0 Yip1 domain TPR_2 PF07719.17 KOO33536.1 - 1.7e-22 77.7 55.4 0.00014 21.7 0.5 12.5 12 1 1 13 13 13 7 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33536.1 - 2.2e-22 77.9 42.7 0.00014 21.5 0.3 10.6 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 KOO33536.1 - 2e-18 66.7 54.4 1.9e-05 25.2 0.1 8.7 4 3 5 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 KOO33536.1 - 1.4e-16 59.8 54.0 1.6e-05 25.3 1.8 10.7 7 3 3 11 11 11 5 Tetratricopeptide repeat DnaJ PF00226.31 KOO33536.1 - 2.7e-16 59.5 0.0 7.8e-16 58.0 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain TPR_19 PF14559.6 KOO33536.1 - 1e-12 48.4 50.1 2.8e-05 24.5 10.0 8.0 5 3 3 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOO33536.1 - 2.6e-12 46.2 37.5 0.0022 17.6 0.1 8.9 8 2 2 10 10 10 6 TPR repeat TPR_8 PF13181.6 KOO33536.1 - 8.2e-10 38.1 21.6 0.0022 18.1 0.0 8.2 9 0 0 9 9 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO33536.1 - 2.2e-07 31.0 24.0 0.023 14.9 0.2 6.0 5 1 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KOO33536.1 - 1.7e-06 28.0 14.8 3.4 8.2 0.1 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO33536.1 - 8.8e-05 22.3 29.7 0.22 11.6 0.1 9.2 9 1 1 10 10 9 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO33536.1 - 0.00082 19.4 7.7 0.13 12.3 0.1 5.0 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 KOO33536.1 - 0.0013 19.0 51.1 0.0054 17.0 0.8 9.5 5 4 5 10 10 10 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO33536.1 - 0.003 18.1 2.5 0.074 13.7 0.3 8.6 11 0 0 11 11 9 2 Tetratricopeptide repeat CLZ PF16526.5 KOO33536.1 - 0.023 15.1 7.6 0.55 10.6 0.6 4.2 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ChAPs PF09295.10 KOO33536.1 - 0.99 8.3 3.9 0.94 8.4 0.5 2.1 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) His_Phos_1 PF00300.22 KOO33537.1 - 7.2e-14 51.9 0.0 1.9e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pkinase PF00069.25 KOO33537.1 - 4.1e-05 23.1 0.0 8e-05 22.1 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33537.1 - 0.0002 20.8 0.0 0.00094 18.5 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Spt4 PF06093.13 KOO33537.1 - 0.14 12.3 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger RRM_1 PF00076.22 KOO33538.1 - 7.7e-07 28.8 0.0 1.5e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 KOO33539.1 - 1.3e-23 82.8 0.9 9e-08 32.7 0.1 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO33539.1 - 2.2e-05 24.7 0.1 0.0022 18.3 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 KOO33539.1 - 0.00043 20.2 0.2 0.001 19.0 0.2 1.6 1 1 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 KOO33539.1 - 0.0006 18.9 0.1 0.17 10.8 0.0 2.2 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein RRM_1 PF00076.22 KOO33539.1 - 0.0026 17.6 0.0 0.012 15.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF664 PF04978.12 KOO33540.1 - 0.039 14.4 0.3 0.81 10.1 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF664) DUF4058 PF13267.6 KOO33541.1 - 0.085 12.3 0.2 0.11 11.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4058) PI-PLC-X PF00388.19 KOO33542.1 - 1.7e-22 79.6 0.1 1.2e-11 44.4 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KOO33542.1 - 8e-21 74.5 0.0 2e-20 73.3 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 KOO33542.1 - 0.00033 20.9 0.0 0.00076 19.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF2834 PF11196.8 KOO33542.1 - 0.17 12.3 7.7 0.082 13.3 3.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2834) SQAPI PF16845.5 KOO33543.1 - 0.00082 19.7 0.0 0.0015 18.8 0.0 1.4 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cystatin PF00031.21 KOO33543.1 - 0.012 15.8 0.0 0.019 15.2 0.0 1.3 1 0 0 1 1 1 0 Cystatin domain EF-hand_1 PF00036.32 KOO33544.1 - 1.4e-21 74.3 0.4 3.2e-05 23.2 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO33544.1 - 1.1e-19 68.6 0.1 0.00096 18.9 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO33544.1 - 5e-18 65.3 1.0 4.7e-09 36.6 0.1 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO33544.1 - 1.1e-15 56.3 3.2 4.6e-05 22.7 0.6 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO33544.1 - 1.1e-11 44.4 0.1 0.024 14.5 0.1 3.7 3 1 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO33544.1 - 1.2e-05 25.6 0.0 0.00032 21.0 0.0 2.3 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO33544.1 - 0.00014 22.1 0.0 0.063 13.6 0.0 3.3 4 0 0 4 4 4 1 EF-hand domain Toprim_2 PF13155.6 KOO33544.1 - 0.014 15.8 0.2 2.6 8.5 0.0 2.7 1 1 2 3 3 3 0 Toprim-like EF-hand_4 PF12763.7 KOO33544.1 - 0.024 14.6 0.1 0.89 9.5 0.0 2.8 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO33544.1 - 0.11 12.4 0.1 5.4 7.0 0.0 2.9 3 0 0 3 3 3 0 EF hand Desulfoferrodox PF01880.18 KOO33547.1 - 1.2e-07 32.2 0.1 3.1e-07 30.9 0.1 1.6 1 1 0 1 1 1 1 Desulfoferrodoxin Cwf_Cwc_15 PF04889.12 KOO33548.1 - 0.3 10.8 24.2 0.59 9.8 5.6 3.2 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein AAA_2 PF07724.14 KOO33549.1 - 1.3e-14 54.7 0.0 8.3e-14 52.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 KOO33549.1 - 1.5e-09 38.4 0.0 5e-09 36.7 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MCM PF00493.23 KOO33549.1 - 2.3e-06 26.9 0.0 3.5e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain Mg_chelatase PF01078.21 KOO33549.1 - 3.6e-06 26.5 0.6 0.13 11.6 0.2 3.3 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOO33549.1 - 0.00011 22.3 1.4 0.00046 20.2 0.1 2.7 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO33549.1 - 0.00028 21.3 3.7 0.00034 21.0 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain IstB_IS21 PF01695.17 KOO33549.1 - 0.001 18.9 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 KOO33549.1 - 0.0025 18.3 0.0 0.0064 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 KOO33549.1 - 0.0027 17.5 0.0 0.0057 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOO33549.1 - 0.003 17.2 0.0 0.0063 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO33549.1 - 0.0032 17.7 1.2 0.014 15.6 0.1 2.7 3 1 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 KOO33549.1 - 0.013 15.2 0.0 0.23 11.2 0.0 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 KOO33549.1 - 0.018 14.7 0.0 0.03 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOO33549.1 - 0.022 15.3 0.0 0.066 13.7 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_3 PF07726.11 KOO33549.1 - 0.038 13.9 0.0 0.64 9.9 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 KOO33549.1 - 0.058 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KOO33549.1 - 0.062 13.5 0.8 0.22 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain VWA_CoxE PF05762.14 KOO33549.1 - 0.064 12.6 6.2 0.14 11.5 6.2 1.5 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein NACHT PF05729.12 KOO33549.1 - 0.075 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RuvB_N PF05496.12 KOO33549.1 - 0.096 12.4 0.1 0.43 10.3 0.1 2.1 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Bac_DnaA PF00308.18 KOO33549.1 - 0.099 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_7 PF12775.7 KOO33549.1 - 0.19 11.2 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 KOO33549.1 - 0.21 11.3 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 KOO33549.1 - 0.25 11.8 0.0 0.45 10.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase ArnB_C PF18677.1 KOO33549.1 - 2 8.6 5.2 0.29 11.3 0.6 1.9 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain Glutaredoxin PF00462.24 KOO33550.1 - 2e-05 24.7 0.0 3.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin zf-RING_UBOX PF13445.6 KOO33551.1 - 7e-08 32.4 5.2 1e-07 31.8 5.2 1.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOO33551.1 - 1.2e-07 31.5 5.9 1.6e-07 31.1 5.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO33551.1 - 9.8e-07 28.5 4.8 1.4e-06 28.1 4.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO33551.1 - 6.9e-06 25.9 5.3 1.1e-05 25.3 5.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOO33551.1 - 1.4e-05 24.8 6.1 2.1e-05 24.3 6.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOO33551.1 - 6.9e-05 22.9 6.1 0.00013 22.1 6.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KOO33551.1 - 0.00011 22.4 5.0 0.00016 21.9 5.0 1.2 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KOO33551.1 - 0.0019 18.0 5.0 0.0029 17.4 5.0 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-NOSIP PF15906.5 KOO33551.1 - 0.061 13.5 0.2 0.07 13.3 0.2 1.1 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_11 PF17123.5 KOO33551.1 - 1.2 9.0 8.9 3.5 7.5 8.9 1.8 1 1 0 1 1 1 0 RING-like zinc finger Bud13 PF09736.9 KOO33552.1 - 2e-06 28.3 2.9 4.1e-05 24.0 0.0 2.4 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex Hydantoinase_A PF01968.18 KOO33552.1 - 0.032 13.5 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase SelP_N PF04592.14 KOO33552.1 - 0.26 10.6 6.8 0.33 10.3 6.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Kelch_1 PF01344.25 KOO33553.1 - 6.4e-09 35.3 5.6 0.002 17.7 0.0 4.3 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 KOO33553.1 - 3e-07 30.5 2.0 0.15 12.4 0.0 5.0 5 1 1 6 6 6 2 Kelch motif Kelch_2 PF07646.15 KOO33553.1 - 1.6e-05 24.7 1.3 6.9 6.8 0.0 4.7 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 KOO33553.1 - 0.00024 21.3 2.8 1.7 9.0 0.0 5.0 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO33553.1 - 0.0011 18.9 1.6 0.5 10.4 0.0 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO33553.1 - 0.0034 17.3 1.6 0.0096 15.9 0.0 2.6 3 0 0 3 3 3 1 Kelch motif C2 PF00168.30 KOO33555.1 - 1.9e-18 66.7 0.0 5.5e-18 65.1 0.0 1.7 2 0 0 2 2 2 1 C2 domain EF-hand_6 PF13405.6 KOO33555.1 - 1.3e-17 62.2 1.8 9.1e-06 25.2 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO33555.1 - 3e-14 51.4 0.0 4.2e-05 22.8 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KOO33555.1 - 1.3e-13 51.2 0.1 6.3e-08 33.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO33555.1 - 6.3e-13 47.6 0.1 0.00012 21.4 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO33555.1 - 6.7e-05 22.7 0.0 0.44 10.4 0.0 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO33555.1 - 0.017 15.4 0.0 1.9 8.9 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO33555.1 - 0.081 13.2 0.0 7.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2749 PF10907.8 KOO33555.1 - 0.35 11.1 1.2 26 5.1 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) PRIMA1 PF16101.5 KOO33555.1 - 2.1 8.4 7.5 22 5.1 6.7 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 KOO33555.1 - 2.6 7.5 6.0 5 6.5 6.0 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal TPR_12 PF13424.6 KOO33556.1 - 3.4e-47 158.6 22.6 1e-17 64.2 2.5 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO33556.1 - 3.5e-45 150.7 17.2 3e-13 49.2 0.3 4.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33556.1 - 2.6e-19 68.1 7.9 0.00016 21.4 0.1 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO33556.1 - 1.2e-17 62.5 3.8 0.00055 19.9 0.0 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO33556.1 - 2.5e-14 52.2 11.7 0.0031 17.5 0.1 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO33556.1 - 1.5e-11 44.3 2.6 1.1e-08 34.9 0.9 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_4 PF07721.14 KOO33556.1 - 7.1e-11 41.7 1.6 0.14 12.9 0.0 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO33556.1 - 3.7e-10 40.3 11.4 0.00042 20.9 1.0 4.1 1 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO33556.1 - 3.7e-09 36.0 14.3 0.036 14.1 0.2 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO33556.1 - 1.7e-07 31.2 9.5 0.083 13.3 0.0 5.0 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO33556.1 - 5.6e-07 29.2 8.2 0.85 9.4 0.1 4.3 4 0 0 4 4 4 3 TPR repeat Osmo_CC PF08946.10 KOO33556.1 - 2.7e-06 27.5 0.7 0.89 9.9 0.1 3.6 3 0 0 3 3 3 2 Osmosensory transporter coiled coil TPR_14 PF13428.6 KOO33556.1 - 6.1e-06 26.6 13.6 0.59 11.1 0.2 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF2399 PF09664.10 KOO33556.1 - 8.6e-05 22.5 1.6 0.28 11.1 0.0 3.1 1 1 2 3 3 3 2 Protein of unknown function C-terminus (DUF2399) TPR_3 PF07720.12 KOO33556.1 - 0.0005 20.0 0.1 4.3 7.4 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO33556.1 - 0.0028 18.1 12.5 0.027 15.0 3.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 KOO33556.1 - 0.0044 16.7 5.2 3.3 7.4 0.4 3.9 1 1 2 3 3 3 1 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 KOO33556.1 - 0.0053 17.3 9.4 18 6.2 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF630 PF04783.12 KOO33556.1 - 0.0072 16.5 1.0 15 5.9 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF630) TPR_5 PF12688.7 KOO33556.1 - 0.0089 16.3 8.0 0.14 12.4 3.3 3.1 1 1 1 3 3 3 1 Tetratrico peptide repeat MIT PF04212.18 KOO33556.1 - 0.029 14.4 0.4 25 5.0 0.0 3.4 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF2806 PF10987.8 KOO33556.1 - 0.032 14.1 0.1 11 5.8 0.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2806) Transposase_1 PF01359.18 KOO33556.1 - 0.045 13.6 0.0 2.7 7.9 0.0 3.2 4 0 0 4 4 4 0 Transposase (partial DDE domain) TetR_C_18 PF17923.1 KOO33556.1 - 0.056 14.0 1.8 72 3.9 0.0 3.8 3 1 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain DUF4810 PF16068.5 KOO33556.1 - 0.26 11.9 3.0 74 4.0 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4810) DUF5302 PF17227.2 KOO33556.1 - 0.44 11.6 6.0 28 5.8 0.1 4.0 4 0 0 4 4 4 0 Family of unknown function (DUF5302) HisKA_3 PF07730.13 KOO33556.1 - 0.96 10.0 8.5 6.6 7.3 1.6 3.6 3 1 0 3 3 3 0 Histidine kinase PPR_1 PF12854.7 KOO33556.1 - 4.1 7.2 6.0 65 3.4 0.1 3.9 4 0 0 4 4 4 0 PPR repeat TPR_10 PF13374.6 KOO33557.1 - 2.7e-57 189.2 23.1 1.1e-12 47.4 0.2 7.6 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_12 PF13424.6 KOO33557.1 - 5.2e-50 167.7 21.1 1.7e-14 53.8 2.9 6.3 2 2 4 6 6 6 5 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO33557.1 - 1.6e-18 67.2 5.2 4.1e-14 52.7 1.4 2.9 1 1 0 1 1 1 1 MalT-like TPR region TPR_8 PF13181.6 KOO33557.1 - 1.6e-14 52.8 0.8 0.039 14.2 0.0 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33557.1 - 4.4e-14 51.6 3.8 0.0036 17.0 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_4 PF07721.14 KOO33557.1 - 1.7e-12 46.7 20.4 0.015 15.9 0.3 8.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO33557.1 - 4.1e-11 42.1 10.1 0.13 12.4 0.1 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO33557.1 - 1.7e-10 40.6 0.3 0.41 11.1 0.0 6.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO33557.1 - 2.2e-07 31.2 12.8 0.0082 16.6 0.8 4.7 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO33557.1 - 3.4e-07 29.8 14.5 0.084 12.9 0.2 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO33557.1 - 5.2e-07 29.8 8.4 3.5 7.9 0.0 6.1 6 1 0 6 6 5 3 Osmosensory transporter coiled coil TPR_16 PF13432.6 KOO33557.1 - 3.5e-06 27.6 21.5 0.76 10.5 0.1 6.7 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOO33557.1 - 0.00015 21.4 6.6 3.8 7.3 0.1 6.0 6 0 0 6 6 6 1 TPR repeat TPR_21 PF09976.9 KOO33557.1 - 0.62 9.7 5.7 0.63 9.7 1.6 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain TPR_14 PF13428.6 KOO33557.1 - 0.84 10.6 25.3 48 5.2 0.1 7.4 7 1 1 8 8 6 0 Tetratricopeptide repeat Sugar_tr PF00083.24 KOO33558.1 - 3.3e-21 75.7 15.8 9.2e-19 67.6 5.2 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOO33558.1 - 3.7e-13 49.1 28.0 3.7e-13 49.1 28.0 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily TIP49 PF06068.13 KOO33560.1 - 4.4e-170 565.5 0.3 5.6e-170 565.2 0.3 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 KOO33560.1 - 7e-23 80.6 0.0 1.8e-22 79.2 0.0 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 KOO33560.1 - 1.1e-11 45.2 0.5 4.4e-07 30.4 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOO33560.1 - 1.7e-10 40.9 0.4 5.2e-07 29.6 0.1 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOO33560.1 - 1e-07 32.3 0.4 0.0023 18.2 0.4 2.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO33560.1 - 1.8e-05 25.2 0.2 0.00022 21.6 0.2 2.3 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 KOO33560.1 - 6.7e-05 22.4 0.7 0.0029 17.0 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 KOO33560.1 - 7.4e-05 23.0 0.1 0.00027 21.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KOO33560.1 - 0.00027 21.0 0.1 0.038 14.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KOO33560.1 - 0.00041 20.0 0.1 0.0031 17.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOO33560.1 - 0.00094 19.5 0.8 1.9 8.8 0.2 2.5 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 KOO33560.1 - 0.0027 17.1 0.1 0.0061 15.9 0.0 1.6 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Sigma54_activat PF00158.26 KOO33560.1 - 0.0065 16.2 0.3 2.7 7.7 0.1 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain ResIII PF04851.15 KOO33560.1 - 0.0073 16.3 0.1 0.49 10.4 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_18 PF13238.6 KOO33560.1 - 0.0081 16.7 0.1 0.028 15.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO33560.1 - 0.0092 16.1 0.0 0.03 14.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KOO33560.1 - 0.012 15.7 0.0 2.6 8.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KOO33560.1 - 0.017 14.8 0.1 0.036 13.8 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 KOO33560.1 - 0.028 13.7 0.2 0.075 12.3 0.2 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.6 KOO33560.1 - 0.033 14.6 0.3 0.32 11.4 0.0 2.4 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 KOO33560.1 - 0.055 12.7 0.0 0.1 11.8 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 KOO33560.1 - 0.061 13.3 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 KOO33560.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF815 PF05673.13 KOO33560.1 - 0.13 11.3 0.0 0.3 10.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 KOO33560.1 - 0.14 11.7 0.1 0.59 9.6 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region SGL PF08450.12 KOO33562.1 - 3.1e-06 27.0 0.0 3.5e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region DUF802 PF05650.11 KOO33563.1 - 0.00079 19.8 2.8 0.00079 19.8 2.8 3.5 2 2 1 3 3 3 1 Domain of unknown function (DUF802) CENP-F_leu_zip PF10473.9 KOO33563.1 - 0.005 16.9 22.2 0.038 14.0 5.9 2.5 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FTO_CTD PF12934.7 KOO33563.1 - 1.2 8.8 7.4 1 9.1 1.3 2.2 1 1 1 2 2 2 0 FTO C-terminal domain AAA_13 PF13166.6 KOO33563.1 - 2.5 6.7 17.0 3.1 6.3 17.0 1.1 1 0 0 1 1 1 0 AAA domain GAS PF13851.6 KOO33563.1 - 3.2 7.0 21.8 6.6 6.0 19.3 2.4 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding TFIIA PF03153.13 KOO33563.1 - 6.6 6.6 14.9 8.6 6.2 14.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.6 KOO33563.1 - 7 5.9 20.3 10 5.4 20.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Arm PF00514.23 KOO33564.1 - 0.012 15.6 9.9 4.1 7.6 0.2 5.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Ank_4 PF13637.6 KOO33566.1 - 2.5e-18 66.2 0.4 8e-10 39.1 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO33566.1 - 8.3e-16 57.9 0.7 9.8e-13 48.1 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO33566.1 - 1.8e-14 54.1 0.1 1.8e-11 44.4 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO33566.1 - 2e-10 40.6 0.0 0.00045 20.5 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO33566.1 - 4.2e-10 39.0 0.0 8.4e-05 22.7 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat Abhydrolase_9_N PF15420.6 KOO33567.1 - 0.02 14.9 2.2 0.044 13.8 2.2 1.5 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Mito_fiss_reg PF05308.11 KOO33567.1 - 0.04 14.0 4.1 0.11 12.6 4.1 1.7 1 0 0 1 1 1 0 Mitochondrial fission regulator ABC_tran PF00005.27 KOO33568.1 - 1.7e-31 109.6 0.0 2.6e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOO33568.1 - 6.4e-23 81.8 0.9 9.6e-23 81.2 0.1 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 KOO33568.1 - 4.8e-06 26.2 0.0 0.00027 20.4 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KOO33568.1 - 0.00044 20.5 0.1 0.016 15.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO33568.1 - 0.00071 20.0 2.1 0.0061 16.9 2.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 KOO33568.1 - 0.0011 19.4 0.1 2.3 8.7 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KOO33568.1 - 0.0014 18.5 0.0 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 KOO33568.1 - 0.0047 16.7 0.0 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 KOO33568.1 - 0.0055 16.3 0.8 0.078 12.5 0.1 2.2 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 KOO33568.1 - 0.012 15.8 0.4 0.16 12.2 0.4 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.12 KOO33568.1 - 0.013 14.8 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 KOO33568.1 - 0.013 15.2 0.5 0.47 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KOO33568.1 - 0.026 14.4 0.0 4.4 7.2 0.0 2.2 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 KOO33568.1 - 0.026 14.5 0.1 0.57 10.2 0.0 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 KOO33568.1 - 0.043 13.7 0.0 0.086 12.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain NACHT PF05729.12 KOO33568.1 - 0.11 12.4 0.0 0.63 9.9 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 KOO33568.1 - 0.15 12.6 0.0 0.38 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 KOO33568.1 - 0.23 11.2 0.0 0.45 10.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Gp_dh_C PF02800.20 KOO33569.1 - 1.6e-11 44.1 0.0 2e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain IQ PF00612.27 KOO33570.1 - 0.015 15.0 2.6 0.037 13.8 2.6 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Hep_59 PF07052.11 KOO33571.1 - 1.3e-20 74.1 0.0 1.9e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Hepatocellular carcinoma-associated antigen 59 Tet_JBP PF12851.7 KOO33571.1 - 0.1 11.9 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily COX6B PF02297.17 KOO33572.1 - 5.5e-10 39.3 7.0 7.2e-10 39.0 7.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Pkinase PF00069.25 KOO33573.1 - 3.2e-44 151.3 0.0 1.4e-28 100.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain B56 PF01603.20 KOO33573.1 - 4.7e-29 101.6 0.0 6.8e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Pkinase_Tyr PF07714.17 KOO33573.1 - 4.5e-24 85.1 0.0 6.2e-16 58.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 KOO33573.1 - 0.015 14.7 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sigma70_r2 PF04542.14 KOO33574.1 - 1.6e-22 79.0 0.1 1.2e-21 76.3 0.0 2.3 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r3 PF04539.16 KOO33574.1 - 2.8e-12 46.6 0.6 2.2e-08 34.1 0.0 2.5 2 0 0 2 2 2 2 Sigma-70 region 3 Sigma70_r4 PF04545.16 KOO33574.1 - 6.7e-11 41.5 1.1 1.9e-08 33.7 0.4 2.7 2 0 0 2 2 2 2 Sigma-70, region 4 Sigma70_r1_2 PF00140.20 KOO33574.1 - 0.0054 16.7 3.3 0.0058 16.6 0.3 2.5 2 1 0 2 2 2 1 Sigma-70 factor, region 1.2 HTH_37 PF13744.6 KOO33574.1 - 0.023 14.6 0.8 9 6.3 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_3 PF01381.22 KOO33574.1 - 0.039 14.0 0.1 5.1 7.2 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix WW PF00397.26 KOO33575.1 - 6.4e-18 64.5 4.0 8.1e-12 45.0 0.8 2.5 2 0 0 2 2 2 2 WW domain zf-CCCH PF00642.24 KOO33575.1 - 0.00032 20.5 7.2 0.065 13.2 2.5 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) MbtH PF03621.13 KOO33575.1 - 0.071 12.6 2.8 6.2 6.4 0.1 2.5 2 0 0 2 2 2 0 MbtH-like protein zf-CCCH_3 PF15663.5 KOO33575.1 - 0.095 12.9 0.4 3.3 8.0 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger containing family Acetyltransf_1 PF00583.25 KOO33576.1 - 3.7e-08 33.6 0.0 6.7e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO33576.1 - 0.00024 21.5 0.0 0.00043 20.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO33576.1 - 0.00036 20.5 0.0 0.00066 19.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TetR_N PF00440.23 KOO33576.1 - 0.024 14.4 2.3 0.23 11.3 0.0 2.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Cnd1 PF12717.7 KOO33577.1 - 2.4e-08 34.2 0.3 0.0002 21.4 0.1 3.2 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 KOO33577.1 - 4.9e-06 26.4 14.4 0.084 13.0 0.2 6.2 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO33577.1 - 1.9e-05 25.0 21.0 0.025 15.1 0.3 5.9 4 2 2 6 6 6 3 HEAT-like repeat Adaptin_N PF01602.20 KOO33577.1 - 4e-05 22.4 0.0 0.046 12.3 0.0 2.2 1 1 1 2 2 2 2 Adaptin N terminal region HEAT_2 PF13646.6 KOO33577.1 - 4.3e-05 23.8 20.9 0.0014 19.0 5.2 3.7 1 1 4 5 5 5 4 HEAT repeats HEAT PF02985.22 KOO33577.1 - 0.00011 22.1 13.4 0.045 14.0 0.1 5.0 6 1 0 6 6 6 2 HEAT repeat ACT PF01842.25 KOO33577.1 - 0.052 13.3 0.1 0.19 11.5 0.1 2.0 1 0 0 1 1 1 0 ACT domain V-ATPase_H_C PF11698.8 KOO33577.1 - 0.093 12.9 0.4 2.1 8.5 0.1 2.8 3 0 0 3 3 3 0 V-ATPase subunit H ABC_tran_CTD PF16326.5 KOO33577.1 - 0.23 11.8 0.6 0.95 9.8 0.3 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain Ceramidase_alk PF04734.13 KOO33579.1 - 8e-185 615.3 0.0 9.5e-185 615.0 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 KOO33579.1 - 4e-24 85.4 0.0 6.6e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Peptidase_M22 PF00814.25 KOO33580.1 - 2.4e-43 148.8 0.0 3.3e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family TsaE PF02367.17 KOO33580.1 - 6.8e-20 71.3 0.0 6.4e-19 68.2 0.0 2.1 1 1 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Carbam_trans_N PF02543.15 KOO33580.1 - 0.00017 21.4 0.0 0.00024 20.9 0.0 1.1 1 0 0 1 1 1 1 Carbamoyltransferase N-terminus AAA_16 PF13191.6 KOO33580.1 - 0.025 15.0 0.3 0.17 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain NIF PF03031.18 KOO33581.1 - 3.3e-18 65.9 0.0 5.2e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase CPP1-like PF11833.8 KOO33582.1 - 2.6e-13 50.1 0.0 4.1e-13 49.4 0.0 1.3 1 1 0 1 1 1 1 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DnaJ PF00226.31 KOO33582.1 - 0.00081 19.5 0.1 0.0013 18.8 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain CytB6-F_Fe-S PF08802.10 KOO33582.1 - 0.042 13.9 1.0 0.15 12.1 1.0 2.0 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit Swi3 PF07962.12 KOO33583.1 - 1.4e-19 69.9 0.1 2.3e-19 69.2 0.1 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 FliD_N PF02465.18 KOO33584.1 - 0.015 16.0 5.1 0.51 11.1 0.0 3.9 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Baculo_PEP_C PF04513.12 KOO33584.1 - 0.017 15.2 0.1 2.1 8.4 0.1 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HAUS-augmin3 PF14932.6 KOO33584.1 - 0.063 12.8 7.1 0.036 13.7 4.5 1.9 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Snapin_Pallidin PF14712.6 KOO33584.1 - 0.088 13.2 4.6 5.1 7.6 0.0 2.9 2 1 0 2 2 2 0 Snapin/Pallidin Syntaxin-6_N PF09177.11 KOO33584.1 - 0.73 10.4 4.0 0.66 10.6 2.1 2.0 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF724 PF05266.14 KOO33584.1 - 2.6 7.8 7.4 6.7 6.5 2.3 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF724) DHR10 PF18595.1 KOO33584.1 - 3.7 7.6 19.2 0.61 10.2 6.9 3.7 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain STI1 PF17830.1 KOO33585.1 - 0.0017 18.3 22.7 0.07 13.1 1.5 3.7 2 2 1 3 3 3 2 STI1 domain GerD PF17898.1 KOO33585.1 - 0.0026 17.7 9.0 0.063 13.2 4.6 2.3 2 0 0 2 2 2 2 Spore germination GerD central core domain NOA36 PF06524.12 KOO33585.1 - 6.8 5.9 9.1 8.5 5.6 9.1 1.1 1 0 0 1 1 1 0 NOA36 protein MORN PF02493.20 KOO33586.1 - 5.9e-31 104.5 42.8 4.7e-06 26.2 1.0 8.0 7 1 1 8 8 8 7 MORN repeat PUB PF09409.10 KOO33586.1 - 6.2e-19 67.7 0.0 1.2e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 PUB domain FA_desaturase PF00487.24 KOO33588.1 - 1e-18 68.1 13.9 1.9e-18 67.3 13.9 1.4 1 1 0 1 1 1 1 Fatty acid desaturase DUF327 PF03885.13 KOO33588.1 - 0.26 11.3 0.0 0.42 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF327) EF-hand_1 PF00036.32 KOO33590.1 - 1.2e-26 90.2 5.7 1.5e-05 24.2 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO33590.1 - 1.4e-25 87.0 8.2 3.1e-05 23.6 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO33590.1 - 7.9e-21 74.3 0.0 1.7e-08 34.8 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO33590.1 - 2.6e-19 67.8 7.4 0.00029 20.2 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO33590.1 - 8.1e-11 41.6 8.1 0.009 15.8 0.2 4.3 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO33590.1 - 1.3e-05 25.4 1.8 0.04 14.2 0.1 3.9 1 1 3 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO33590.1 - 0.00042 20.3 0.2 5.4 6.9 0.1 3.3 2 1 1 3 3 3 2 Caleosin related protein EF-hand_4 PF12763.7 KOO33590.1 - 0.00056 19.8 0.2 1 9.3 0.0 3.8 4 0 0 4 4 4 1 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.25 KOO33591.1 - 4.4e-43 147.5 0.0 6.4e-43 147.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33591.1 - 7.2e-39 133.6 0.0 1.1e-38 133.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO33591.1 - 0.18 11.1 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pyr_redox_dim PF02852.22 KOO33592.1 - 1.7e-13 50.8 0.4 2.8e-13 50.1 0.4 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 KOO33592.1 - 3.6e-13 49.4 0.4 4.6e-13 49.1 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOO33593.1 - 9.5e-15 54.6 0.1 1.6e-14 53.9 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO33593.1 - 9.8e-07 29.3 0.2 2.4e-06 28.0 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF3918 PF13056.6 KOO33593.1 - 0.41 10.3 1.3 0.91 9.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3918) Upf2 PF04050.14 KOO33595.1 - 0.07 13.9 0.2 0.12 13.1 0.2 1.3 1 0 0 1 1 1 0 Up-frameshift suppressor 2 RPAP1_N PF08621.10 KOO33595.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 RPAP1-like, N-terminal SLATT_1 PF18181.1 KOO33595.1 - 2.5 8.0 6.3 3.7 7.5 0.2 3.1 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 EF-hand_1 PF00036.32 KOO33597.1 - 2e-08 33.2 0.9 0.0065 15.9 0.1 2.7 2 0 0 2 2 2 2 EF hand LRR_6 PF13516.6 KOO33597.1 - 3.1e-08 33.0 13.2 1.4 9.2 0.8 7.3 8 0 0 8 8 8 4 Leucine Rich repeat EF-hand_7 PF13499.6 KOO33597.1 - 6e-08 33.0 0.1 1.4e-07 31.9 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO33597.1 - 1.2e-06 28.3 1.0 0.00059 19.6 0.0 2.9 1 1 1 2 2 2 2 EF-hand domain pair ART PF01129.18 KOO33597.1 - 6e-06 25.7 0.0 1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase EF-hand_6 PF13405.6 KOO33597.1 - 7.1e-06 25.5 0.2 0.0072 16.2 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain ADPrib_exo_Tox PF03496.14 KOO33597.1 - 1.2e-05 24.8 0.0 3.1e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme EF-hand_5 PF13202.6 KOO33597.1 - 4.3e-05 22.8 0.4 0.091 12.3 0.1 2.5 2 0 0 2 2 2 2 EF hand LRR_4 PF12799.7 KOO33597.1 - 0.073 13.5 5.1 29 5.3 0.0 4.8 6 0 0 6 6 6 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO33597.1 - 0.16 11.8 5.6 9 6.2 0.0 4.8 5 0 0 5 5 5 0 Leucine rich repeat Arm PF00514.23 KOO33598.1 - 4.1e-54 179.1 67.3 2.1e-05 24.4 0.5 13.1 13 0 0 13 13 13 12 Armadillo/beta-catenin-like repeat zf-C2H2 PF00096.26 KOO33598.1 - 2.2e-13 49.9 34.4 0.00014 22.1 2.2 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO33598.1 - 4.5e-12 45.8 34.4 3.4e-05 24.1 1.3 4.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO33598.1 - 1.3e-11 44.2 30.3 0.0026 18.4 1.3 4.2 4 0 0 4 4 4 4 C2H2-type zinc finger DUF302 PF03625.14 KOO33598.1 - 7.4e-11 41.8 5.8 5.6 6.9 0.0 10.5 11 0 0 11 11 11 2 Domain of unknown function DUF302 Cnd1 PF12717.7 KOO33598.1 - 0.00014 22.0 0.0 13 5.7 0.0 4.7 3 1 3 6 6 6 1 non-SMC mitotic condensation complex subunit 1 TRL PF13146.6 KOO33598.1 - 0.25 11.6 38.8 1.3 9.4 0.1 8.6 9 2 2 11 11 11 0 TRL-like protein family CHORD PF04968.12 KOO33598.1 - 2.4 9.0 24.9 8.6 7.2 1.3 4.2 1 1 3 4 4 4 0 CHORD zf-C2H2_jaz PF12171.8 KOO33598.1 - 3.6 8.0 8.8 13 6.2 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding PolyA_pol_RNAbd PF12627.7 KOO33599.1 - 0.15 11.8 1.4 5.4 6.9 0.1 2.8 3 0 0 3 3 3 0 Probable RNA and SrmB- binding site of polymerase A Chloroa_b-bind PF00504.21 KOO33600.1 - 2.1e-30 106.4 0.1 2.8e-30 106.0 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein XPG_I PF00867.18 KOO33601.1 - 5e-20 71.7 0.0 1.3e-19 70.3 0.0 1.8 1 1 0 1 1 1 1 XPG I-region XPG_N PF00752.17 KOO33601.1 - 1.3e-14 54.5 0.0 2.2e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 KOO33601.1 - 2.5e-07 30.4 0.0 3.9e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 KOO33601.1 - 0.0097 16.5 0.0 0.022 15.4 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold EF-hand_6 PF13405.6 KOO33602.1 - 5.1e-12 44.7 0.1 3.9e-05 23.2 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain Sigma70_r2 PF04542.14 KOO33602.1 - 4.8e-10 39.1 0.0 1.1e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 EF-hand_7 PF13499.6 KOO33602.1 - 8e-10 39.0 1.1 1.3e-07 31.9 0.3 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO33602.1 - 2.7e-09 35.9 0.2 0.002 17.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO33602.1 - 1.6e-08 34.2 1.0 9.7e-07 28.5 0.1 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO33602.1 - 1.4e-07 30.7 0.3 0.005 16.3 0.0 2.8 2 0 0 2 2 2 2 EF hand Sigma70_r4 PF04545.16 KOO33602.1 - 1.8e-05 24.2 0.2 1.8e-05 24.2 0.2 2.4 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r1_2 PF00140.20 KOO33602.1 - 0.031 14.3 0.3 0.086 12.9 0.3 1.8 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 Caleosin PF05042.13 KOO33602.1 - 0.13 12.2 0.3 20 5.0 0.1 2.7 2 1 1 3 3 3 0 Caleosin related protein FAD-oxidase_C PF02913.19 KOO33603.1 - 5.1e-51 173.7 0.0 8.1e-51 173.1 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KOO33603.1 - 8.8e-28 96.8 0.3 1.8e-27 95.8 0.3 1.6 1 0 0 1 1 1 1 FAD binding domain Fer4_8 PF13183.6 KOO33603.1 - 3.3e-08 33.9 3.2 7.9e-08 32.6 3.2 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 KOO33603.1 - 6.9e-08 33.0 3.0 1.7e-07 31.7 3.0 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 KOO33603.1 - 5.1e-06 26.9 4.9 1.4e-05 25.6 4.9 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 KOO33603.1 - 6.6e-05 22.9 1.6 0.13 12.4 0.2 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 KOO33603.1 - 0.00011 23.1 4.5 0.00023 22.0 4.5 1.6 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4 PF00037.27 KOO33603.1 - 0.0004 20.1 8.9 0.0027 17.5 1.5 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain CCG PF02754.16 KOO33603.1 - 0.00086 19.5 9.8 0.011 15.9 0.0 3.5 4 0 0 4 4 4 2 Cysteine-rich domain Fer4_21 PF14697.6 KOO33603.1 - 0.0015 18.6 1.5 0.36 11.0 0.2 2.7 2 0 0 2 2 2 1 4Fe-4S dicluster domain CHASE8 PF17152.4 KOO33603.1 - 0.009 16.2 0.2 0.029 14.6 0.2 1.9 1 0 0 1 1 1 1 Periplasmic sensor domain Fer4_20 PF14691.6 KOO33603.1 - 0.011 15.5 1.9 0.22 11.3 0.0 2.5 2 0 0 2 2 2 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_9 PF13187.6 KOO33603.1 - 0.065 13.4 8.0 0.41 10.8 1.9 2.3 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 KOO33603.1 - 3.7 7.8 10.0 0.27 11.4 2.4 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_2 PF12797.7 KOO33603.1 - 8 6.8 10.3 0.4 10.9 2.9 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Pkinase PF00069.25 KOO33604.1 - 4.3e-70 236.1 0.0 8.7e-70 235.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33604.1 - 7.7e-34 117.1 0.0 2.1e-33 115.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 KOO33604.1 - 7.7e-13 48.6 0.2 1.4e-12 47.8 0.2 1.4 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 KOO33604.1 - 0.00091 18.6 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Yop-YscD_cpl PF16697.5 KOO33604.1 - 0.0014 18.9 0.0 0.0034 17.7 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 KOO33604.1 - 0.0037 16.1 0.0 0.0061 15.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO33604.1 - 0.011 15.7 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO33604.1 - 0.022 13.7 0.0 0.032 13.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 KOO33604.1 - 0.028 14.0 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 KOO33604.1 - 0.048 13.0 0.1 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KOO33604.1 - 0.082 12.4 0.0 0.25 10.8 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL PH PF00169.29 KOO33605.1 - 1.3e-07 32.1 0.0 2e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.6 KOO33605.1 - 0.0046 16.8 0.0 0.01 15.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain TPR_12 PF13424.6 KOO33606.1 - 0.00016 21.9 1.1 0.0014 18.9 1.1 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO33606.1 - 0.0007 19.5 1.8 0.54 10.5 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33606.1 - 0.0022 17.7 2.3 0.3 11.0 0.3 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO33606.1 - 0.097 13.2 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Bac_GH3_C PF18034.1 KOO33607.1 - 0.2 11.4 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial Glycosyl hydrolase family 3 C-terminal domain WD40 PF00400.32 KOO33608.1 - 6.8e-15 55.2 10.1 0.00025 21.8 0.0 8.8 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO33608.1 - 2.2e-09 37.5 0.1 0.015 15.6 0.0 6.1 3 3 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_8 PF13833.6 KOO33608.1 - 3.8e-06 26.7 0.0 7.7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair PQQ_2 PF13360.6 KOO33608.1 - 6.7e-06 25.9 1.9 0.00073 19.2 0.0 3.2 3 0 0 3 3 3 1 PQQ-like domain EF-hand_5 PF13202.6 KOO33608.1 - 1.8e-05 24.0 0.1 6.1e-05 22.3 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO33608.1 - 7.6e-05 23.1 0.0 0.0014 19.1 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO33608.1 - 0.00014 21.5 0.1 0.00069 19.3 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO33608.1 - 0.0002 20.7 0.1 0.00081 18.8 0.0 2.1 2 0 0 2 2 2 1 EF hand Abhydrolase_6 PF12697.7 KOO33609.1 - 1.6e-11 45.3 1.8 1.8e-11 45.1 1.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO33609.1 - 5.3e-08 32.4 0.0 6.4e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOO33609.1 - 1e-06 28.6 0.0 1e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 KOO33609.1 - 2.9e-06 27.3 0.0 4.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Peptidase_S9 PF00326.21 KOO33609.1 - 0.00038 20.0 0.0 0.00042 19.9 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family HrpB7 PF09486.10 KOO33609.1 - 0.00088 19.7 2.3 0.0013 19.1 2.3 1.2 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) FSH1 PF03959.13 KOO33609.1 - 0.0014 18.3 0.0 0.0015 18.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Ser_hydrolase PF06821.13 KOO33609.1 - 0.0024 17.7 0.0 0.0028 17.5 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase LIP PF03583.14 KOO33609.1 - 0.0057 16.0 0.0 0.0076 15.6 0.0 1.2 1 0 0 1 1 1 1 Secretory lipase Ndr PF03096.14 KOO33609.1 - 0.018 13.8 0.0 0.023 13.4 0.0 1.1 1 0 0 1 1 1 0 Ndr family Abhydrolase_2 PF02230.16 KOO33609.1 - 0.1 12.4 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DLH PF01738.18 KOO33609.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family BRO1 PF03097.18 KOO33610.1 - 1.1e-61 208.9 0.0 1.4e-61 208.5 0.0 1.1 1 0 0 1 1 1 1 BRO1-like domain UBA PF00627.31 KOO33610.1 - 0.00018 21.3 0.1 0.00043 20.1 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Importin_rep_3 PF18806.1 KOO33613.1 - 0.029 14.4 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 Importin 13 repeat SesA PF17107.5 KOO33613.1 - 0.05 13.8 0.3 0.11 12.7 0.1 1.7 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Dpy-30 PF05186.13 KOO33613.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Dpy-30 motif Ammonium_transp PF00909.21 KOO33614.1 - 3.5e-109 365.1 29.4 4.2e-109 364.9 29.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family PP2C PF00481.21 KOO33615.1 - 8.6e-18 64.9 0.0 1.3e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Ank_2 PF12796.7 KOO33615.1 - 3.3e-17 62.9 6.3 4.7e-10 39.9 0.3 3.0 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 KOO33615.1 - 2.2e-10 40.5 5.0 0.018 15.5 0.1 4.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KOO33615.1 - 1.7e-09 38.0 0.7 0.00013 22.4 0.2 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO33615.1 - 2.3e-07 30.9 1.9 0.031 14.6 0.2 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33615.1 - 2.8e-06 27.2 1.2 0.65 10.7 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat SpoIIE PF07228.12 KOO33615.1 - 4.7e-05 23.4 2.9 0.0014 18.6 0.9 2.8 3 0 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) Asparaginase_2 PF01112.18 KOO33616.1 - 6.8e-74 248.6 0.5 8.5e-74 248.3 0.5 1.0 1 0 0 1 1 1 1 Asparaginase G_glu_transpept PF01019.21 KOO33616.1 - 0.065 12.0 0.0 0.089 11.5 0.0 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Cation_efflux PF01545.21 KOO33617.1 - 3.1e-22 79.3 7.4 6.8e-21 74.9 7.4 2.0 1 1 0 1 1 1 1 Cation efflux family DctQ PF04290.12 KOO33617.1 - 0.00036 20.5 2.4 0.0008 19.3 0.8 2.0 2 0 0 2 2 2 1 Tripartite ATP-independent periplasmic transporters, DctQ component DUF2076 PF09849.9 KOO33617.1 - 0.37 10.8 1.1 0.51 10.3 1.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Chloroa_b-bind PF00504.21 KOO33618.1 - 4.2e-30 105.4 0.0 5.5e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DUF441 PF04284.13 KOO33618.1 - 0.092 12.8 0.0 0.4 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF441) DnaJ PF00226.31 KOO33619.1 - 4.1e-05 23.6 0.0 0.00022 21.3 0.0 2.2 2 0 0 2 2 2 1 DnaJ domain NapB PF03892.14 KOO33619.1 - 0.56 10.2 0.1 0.56 10.2 0.1 2.4 1 1 0 2 2 2 0 Nitrate reductase cytochrome c-type subunit (NapB) EF-hand_7 PF13499.6 KOO33621.1 - 1.8e-11 44.3 7.1 2e-06 28.1 2.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO33621.1 - 7.4e-11 41.1 4.6 0.0042 16.9 0.4 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO33621.1 - 5.1e-09 35.1 15.5 0.0031 17.0 0.8 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO33621.1 - 1.9e-07 30.8 11.8 8.1e-07 28.8 2.1 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO33621.1 - 0.0072 15.8 7.7 1.8 8.2 0.1 3.4 3 0 0 3 3 3 2 EF hand cNMP_binding PF00027.29 KOO33622.1 - 0.015 15.3 0.0 0.033 14.2 0.0 1.6 1 1 0 1 1 1 0 Cyclic nucleotide-binding domain Shadoo PF14999.6 KOO33623.1 - 0.13 12.3 0.1 0.13 12.3 0.1 3.0 3 1 0 3 3 3 0 Shadow of prion protein, neuroprotective AMP-binding PF00501.28 KOO33624.1 - 6.9e-96 321.4 0.0 8.9e-96 321.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOO33624.1 - 2.9e-05 25.0 0.1 0.00011 23.2 0.1 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Kinesin PF00225.23 KOO33626.1 - 1.4e-95 320.0 0.0 2.8e-95 319.0 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO33626.1 - 1.1e-41 142.3 0.0 1.8e-36 125.3 0.0 2.6 2 0 0 2 2 2 2 Microtubule binding CENP-Q PF13094.6 KOO33626.1 - 0.00072 19.8 4.6 0.00072 19.8 4.6 4.2 4 1 0 4 4 3 1 CENP-Q, a CENPA-CAD centromere complex subunit MAD PF05557.13 KOO33626.1 - 0.0026 16.2 8.3 0.0026 16.2 8.3 2.7 3 0 0 3 3 3 1 Mitotic checkpoint protein HLH PF00010.26 KOO33626.1 - 0.026 14.5 1.0 1.5 8.8 0.1 3.1 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain OmpH PF03938.14 KOO33626.1 - 0.43 10.9 38.3 0.12 12.7 13.3 3.3 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Filo_VP35 PF02097.15 KOO33626.1 - 1.1 8.2 8.6 8.2 5.4 1.1 3.0 3 0 0 3 3 3 0 Filoviridae VP35 ATG16 PF08614.11 KOO33626.1 - 1.5 9.0 37.8 0.71 10.1 13.6 3.2 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) V_ATPase_I PF01496.19 KOO33626.1 - 3.5 5.4 11.9 4.1 5.2 3.8 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 KOO33626.1 - 4.6 6.7 17.9 0.43 10.1 1.0 2.7 3 0 0 3 3 3 0 Exonuclease VII, large subunit Fmp27_WPPW PF10359.9 KOO33626.1 - 5.4 5.7 16.2 0.55 9.0 5.5 2.3 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain JAB PF01398.21 KOO33627.1 - 5.7e-31 106.9 0.0 1.3e-30 105.8 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 KOO33627.1 - 2.3e-11 44.1 0.8 4.3e-11 43.2 0.8 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 KOO33627.1 - 1.9e-05 24.4 0.0 3.7e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain CIA30 PF08547.12 KOO33628.1 - 4.7e-30 104.7 0.0 5.6e-30 104.5 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Dpy-30 PF05186.13 KOO33630.1 - 0.0089 15.7 0.3 0.028 14.1 0.3 1.9 1 0 0 1 1 1 1 Dpy-30 motif YHS PF04945.13 KOO33630.1 - 0.051 13.7 0.0 0.25 11.5 0.0 2.0 2 0 0 2 2 2 0 YHS domain Exo_endo_phos PF03372.23 KOO33632.1 - 0.023 14.2 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family EF-hand_5 PF13202.6 KOO33633.1 - 0.0047 16.4 0.1 0.01 15.3 0.1 1.5 1 0 0 1 1 1 1 EF hand FliT PF05400.13 KOO33633.1 - 0.06 14.2 21.2 0.098 13.5 8.5 2.9 2 0 0 2 2 2 0 Flagellar protein FliT Dapper PF15268.6 KOO33633.1 - 1.8 7.3 12.4 0.05 12.5 3.1 2.0 2 0 0 2 2 2 0 Dapper Pkinase PF00069.25 KOO33634.1 - 2e-59 201.1 0.3 5.9e-38 130.7 0.0 2.3 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33634.1 - 7.2e-30 104.1 2.6 3.2e-22 79.1 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 KOO33634.1 - 5.9e-05 23.1 0.1 0.29 11.0 0.1 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_C PF00433.24 KOO33634.1 - 0.0014 19.3 0.1 0.0032 18.1 0.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KOO33634.1 - 0.0018 17.6 0.0 0.31 10.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 KOO33634.1 - 0.007 15.3 0.0 0.016 14.2 0.0 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Glyco_transf_34 PF05637.12 KOO33635.1 - 2.9e-26 92.7 0.0 1.1e-24 87.5 0.0 2.5 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 KOO33635.1 - 9.8e-05 22.4 0.0 0.00015 21.8 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DcrB PF08786.11 KOO33635.1 - 0.18 11.9 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 DcrB MIOX PF05153.15 KOO33638.1 - 4.4e-11 42.8 0.1 1.2e-06 28.3 0.1 3.3 2 1 0 2 2 2 2 Myo-inositol oxygenase DUF737 PF05300.11 KOO33638.1 - 0.18 12.1 2.7 0.37 11.1 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF737) CIA30 PF08547.12 KOO33639.1 - 4.7e-20 72.2 0.0 5.3e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Glyco_transf_8 PF01501.20 KOO33640.1 - 2.1e-07 30.8 0.3 1.5e-06 28.0 0.3 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 Ribosomal_L12 PF00542.19 KOO33642.1 - 2.1e-21 76.0 3.6 2.3e-21 75.9 3.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain Pesticin PF16754.5 KOO33642.1 - 0.03 14.3 0.1 0.031 14.3 0.1 1.1 1 0 0 1 1 1 0 Bacterial toxin homologue of phage lysozyme, C-term Adhesin_P1_N PF18652.1 KOO33643.1 - 0.16 12.0 0.1 0.31 11.1 0.1 1.4 1 0 0 1 1 1 0 Adhesin P1 N-terminal domain MgtE PF01769.16 KOO33644.1 - 1.9e-19 70.2 6.6 2.3e-19 70.0 6.6 1.1 1 0 0 1 1 1 1 Divalent cation transporter FSH1 PF03959.13 KOO33645.1 - 3.3e-22 79.2 0.0 5.9e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Pkinase PF00069.25 KOO33646.1 - 3.8e-34 118.2 0.0 4.9e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33646.1 - 2e-17 63.4 0.0 2.6e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO33646.1 - 4e-05 23.6 2.4 0.00052 20.0 0.1 3.1 1 1 2 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 KOO33646.1 - 0.0056 16.0 0.0 0.0093 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family CBM_19 PF03427.13 KOO33646.1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) Haspin_kinase PF12330.8 KOO33646.1 - 0.13 11.2 0.0 0.19 10.6 0.0 1.3 1 1 0 1 1 1 0 Haspin like kinase domain Myosin_head PF00063.21 KOO33649.1 - 1.1e-196 655.1 0.0 2.7e-194 647.2 0.0 2.1 1 1 0 2 2 2 2 Myosin head (motor domain) PDZ_6 PF17820.1 KOO33649.1 - 2.8e-23 81.5 8.3 4e-09 36.2 0.1 3.7 3 0 0 3 3 3 3 PDZ domain PDZ PF00595.24 KOO33649.1 - 7.2e-19 67.9 7.3 7.8e-07 29.4 0.1 3.7 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KOO33649.1 - 4.6e-14 52.5 2.2 0.0027 18.0 0.0 3.6 3 0 0 3 3 3 3 PDZ domain WW PF00397.26 KOO33649.1 - 1e-05 25.5 0.1 2.2e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 WW domain AAA_22 PF13401.6 KOO33649.1 - 0.075 13.3 0.0 0.31 11.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.12 KOO33649.1 - 0.099 12.2 0.1 0.25 10.8 0.1 1.6 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.6 KOO33649.1 - 0.23 11.8 1.6 1.9 8.9 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain GvpL_GvpF PF06386.11 KOO33649.1 - 9.7 6.0 8.9 0.25 11.2 0.6 2.2 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Alpha_kinase PF02816.18 KOO33650.1 - 1.3e-42 146.0 0.2 3.1e-42 144.8 0.2 1.6 1 1 0 1 1 1 1 Alpha-kinase family DUF1378 PF07125.11 KOO33650.1 - 0.065 13.4 1.9 0.12 12.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1378) Ras PF00071.22 KOO33651.1 - 4e-63 211.8 0.3 4.9e-63 211.6 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO33651.1 - 4.4e-33 114.0 0.4 7.7e-33 113.3 0.2 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO33651.1 - 8.1e-14 51.5 0.1 1e-13 51.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO33651.1 - 2.6e-05 24.3 0.0 4.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO33651.1 - 9.6e-05 22.3 0.1 0.067 13.1 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 KOO33651.1 - 0.00031 20.2 0.1 0.00039 19.9 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOO33651.1 - 0.00083 18.9 0.2 0.0035 16.9 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 KOO33651.1 - 0.0022 18.2 0.1 0.081 13.2 0.1 2.4 2 1 0 2 2 2 1 AAA domain DAP3 PF10236.9 KOO33651.1 - 0.055 12.6 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 SRPRB PF09439.10 KOO33651.1 - 0.056 12.9 0.0 0.1 12.0 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF3456 PF11938.8 KOO33652.1 - 0.036 14.6 2.0 0.47 11.0 0.4 2.3 1 1 1 2 2 2 0 TLR4 regulator and MIR-interacting MSAP LLC1 PF14945.6 KOO33653.1 - 1.2e-07 32.3 0.2 1.2e-07 32.3 0.2 1.1 1 0 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein ARPC4 PF05856.12 KOO33654.1 - 1.4e-71 239.5 3.5 1.6e-71 239.3 3.5 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Fe-S_biosyn PF01521.20 KOO33655.1 - 1.1e-14 54.5 0.0 1.4e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Succ_CoA_lig PF13607.6 KOO33655.1 - 0.069 12.9 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain BTB PF00651.31 KOO33657.1 - 8.4e-15 55.0 0.0 1.7e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain SDA1 PF05285.12 KOO33657.1 - 0.43 9.9 6.7 0.65 9.4 6.7 1.2 1 0 0 1 1 1 0 SDA1 Glutaredoxin PF00462.24 KOO33658.1 - 2.4e-16 59.7 0.1 4.4e-16 58.8 0.0 1.5 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin_2 PF13098.6 KOO33658.1 - 0.00043 20.7 0.1 0.00075 19.9 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_4 PF13462.6 KOO33658.1 - 0.026 14.7 0.4 4.4 7.4 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin Ion_trans PF00520.31 KOO33659.1 - 1.1e-197 653.6 40.6 3.4e-54 183.7 0.1 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 KOO33659.1 - 1.2e-11 44.2 0.2 4.2e-11 42.4 0.1 2.0 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO33659.1 - 4.3e-07 29.0 45.8 0.013 14.2 5.6 8.9 6 4 4 10 10 10 6 Polycystin cation channel Methyltransf_21 PF05050.12 KOO33660.1 - 0.21 11.6 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase FkbM domain EF-hand_6 PF13405.6 KOO33661.1 - 1.4e-09 37.1 0.0 0.0005 19.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO33661.1 - 3.4e-09 35.8 0.3 0.00026 20.4 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO33661.1 - 4.5e-09 35.2 0.0 0.0006 19.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO33661.1 - 4.1e-08 33.5 3.7 0.0096 16.4 0.0 3.6 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO33661.1 - 3.8e-05 23.4 0.0 8.4e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair Drf_FH3 PF06367.16 KOO33662.1 - 4.7e-13 49.2 0.1 1.5e-12 47.6 0.1 1.7 1 1 0 1 1 1 1 Diaphanous FH3 Domain WGR PF05406.15 KOO33663.1 - 7.9e-15 54.7 0.0 1.5e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 WGR domain WWE PF02825.20 KOO33663.1 - 4.1e-11 43.3 1.1 6.8e-11 42.6 1.1 1.4 1 0 0 1 1 1 1 WWE domain PH PF00169.29 KOO33664.1 - 2.2e-08 34.5 0.0 4.5e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 KOO33664.1 - 7.1e-06 26.4 0.0 3e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 KOO33664.1 - 0.015 15.6 0.1 0.065 13.5 0.0 2.1 3 0 0 3 3 3 0 Pleckstrin homology domain PARP PF00644.20 KOO33665.1 - 3.4e-08 33.3 0.0 4.1e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WD40 PF00400.32 KOO33668.1 - 2.9e-30 103.9 7.4 7.1e-08 33.0 0.7 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO33668.1 - 0.00036 20.8 0.3 1 9.7 0.2 3.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOO33668.1 - 3.9 6.0 4.0 32 3.0 0.0 3.5 3 1 1 5 5 5 0 Nucleoporin Nup120/160 YL1 PF05764.13 KOO33669.1 - 0.0028 17.8 0.8 0.0036 17.5 0.8 1.2 1 0 0 1 1 1 1 YL1 nuclear protein GCIP PF13324.6 KOO33669.1 - 0.43 10.1 2.2 0.84 9.2 0.6 1.9 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting STAG PF08514.11 KOO33670.1 - 8.7e-18 64.3 0.1 1.7e-17 63.4 0.1 1.4 1 0 0 1 1 1 1 STAG domain HEAT PF02985.22 KOO33670.1 - 0.01 16.0 6.7 3.5 8.1 0.0 5.3 5 0 0 5 5 5 0 HEAT repeat ABC1 PF03109.16 KOO33671.1 - 4.8e-25 88.0 0.0 7.4e-25 87.4 0.0 1.3 1 0 0 1 1 1 1 ABC1 family RNB PF00773.19 KOO33672.1 - 1e-57 195.9 0.0 4.4e-42 144.6 0.0 2.2 1 1 1 2 2 2 2 RNB domain Rrp44_S1 PF17215.3 KOO33672.1 - 2.7e-05 24.0 0.0 7.4e-05 22.6 0.0 1.7 1 1 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 KOO33672.1 - 3e-05 23.8 0.0 5.9e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain RsgA_GTPase PF03193.16 KOO33672.1 - 0.00036 20.5 0.0 0.016 15.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KOO33672.1 - 0.0093 16.4 1.5 0.016 15.6 0.3 2.0 2 0 0 2 2 2 1 AAA ATPase domain CSD2 PF17876.1 KOO33672.1 - 0.019 15.1 0.0 9 6.5 0.0 3.3 3 0 0 3 3 3 0 Cold shock domain MMR_HSR1 PF01926.23 KOO33672.1 - 0.072 13.2 1.7 2.7 8.1 0.3 3.1 3 1 0 3 3 3 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 KOO33672.1 - 0.093 13.1 0.1 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 RNA helicase KH_1 PF00013.29 KOO33673.1 - 5.2e-10 39.0 0.0 1e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 KOO33673.1 - 0.0034 17.2 0.0 0.0079 16.0 0.0 1.7 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 KOO33673.1 - 0.027 14.3 0.1 0.048 13.5 0.1 1.3 1 0 0 1 1 1 0 KH domain ARL2_Bind_BART PF11527.8 KOO33674.1 - 2.3e-08 34.1 0.9 3.4e-08 33.6 0.9 1.2 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART DUF3006 PF11213.8 KOO33674.1 - 0.13 12.5 0.1 8 6.8 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3006) TPT PF03151.16 KOO33675.1 - 7.5e-27 94.4 3.7 1.1e-26 93.9 3.7 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO33675.1 - 3.9e-09 36.8 25.8 8.6e-06 26.0 8.7 3.3 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 KOO33675.1 - 0.0024 17.1 4.8 0.004 16.4 4.8 1.4 1 1 0 1 1 1 1 UAA transporter family DUF5405 PF17399.2 KOO33675.1 - 0.12 12.7 0.1 2.4 8.5 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5405) FSAP_sig_propep PF03032.15 KOO33675.1 - 0.27 11.3 1.1 0.38 10.8 0.0 1.8 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide Arf PF00025.21 KOO33676.1 - 1.3e-68 229.9 0.0 1.7e-68 229.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOO33676.1 - 6.6e-15 55.4 0.0 9.3e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO33676.1 - 9.7e-13 48.0 0.0 1.2e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KOO33676.1 - 6.8e-12 45.2 0.0 8.5e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KOO33676.1 - 1.4e-10 40.9 0.2 3.4e-06 26.5 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KOO33676.1 - 4.3e-08 32.8 0.0 5.6e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO33676.1 - 1.3e-05 25.3 0.0 2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 KOO33676.1 - 0.064 13.2 0.0 0.13 12.1 0.0 1.7 1 1 0 1 1 1 0 NACHT domain 6PF2K PF01591.18 KOO33676.1 - 0.097 12.0 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Alg14 PF08660.11 KOO33678.1 - 6.5e-65 218.3 0.0 7.2e-65 218.2 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Ank_2 PF12796.7 KOO33679.1 - 4.6e-16 59.2 1.0 4.3e-13 49.6 0.6 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO33679.1 - 5.5e-14 52.1 0.3 2.3e-07 31.0 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO33679.1 - 1.1e-12 48.2 0.5 1.2e-08 35.3 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) EF-hand_6 PF13405.6 KOO33679.1 - 1.3e-11 43.4 2.2 0.00017 21.2 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO33679.1 - 2.7e-10 39.0 1.5 0.00011 21.5 0.2 2.8 2 0 0 2 2 2 2 EF hand Ank_3 PF13606.6 KOO33679.1 - 4e-10 39.1 0.0 0.012 16.1 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KOO33679.1 - 9e-10 38.6 0.1 0.00075 19.8 0.0 4.8 4 1 1 5 5 5 2 Ankyrin repeat EF-hand_7 PF13499.6 KOO33679.1 - 3.5e-08 33.8 9.2 8.8e-07 29.3 1.0 2.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO33679.1 - 1.9e-07 30.8 0.1 8.5e-07 28.7 0.1 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO33679.1 - 4.4e-06 25.9 2.9 0.0063 16.0 0.2 2.5 2 0 0 2 2 2 2 EF hand ADPrib_exo_Tox PF03496.14 KOO33679.1 - 9.4e-05 21.8 0.0 0.00021 20.7 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO33679.1 - 0.00023 20.5 0.0 0.00056 19.3 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ARGLU PF15346.6 KOO33679.1 - 0.017 15.0 5.8 0.067 13.1 5.8 2.0 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 DUF1778 PF08681.11 KOO33679.1 - 0.02 14.8 1.4 0.89 9.5 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1778) SQAPI PF16845.5 KOO33680.1 - 3.7e-07 30.4 0.1 9.7e-07 29.1 0.1 1.7 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cystatin PF00031.21 KOO33680.1 - 0.0015 18.7 0.1 0.004 17.4 0.1 1.7 1 0 0 1 1 1 1 Cystatin domain DHHC PF01529.20 KOO33681.1 - 1.1e-16 61.1 0.1 3.6e-15 56.2 0.1 2.2 1 1 0 1 1 1 1 DHHC palmitoyltransferase Chlorophyllase2 PF12740.7 KOO33682.1 - 9.4e-08 31.3 0.0 1.4e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 KOO33682.1 - 1.2e-06 27.8 0.1 1.7e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Chlorophyllase Hydrolase_4 PF12146.8 KOO33682.1 - 1.5e-06 27.7 0.9 0.13 11.5 0.0 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 PAF-AH_p_II PF03403.13 KOO33682.1 - 8.2e-05 21.3 0.2 0.047 12.2 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_3 PF07859.13 KOO33682.1 - 9.4e-05 22.4 0.1 0.00014 21.8 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOO33682.1 - 0.00049 19.6 0.3 0.4 10.1 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Lipase_3 PF01764.25 KOO33682.1 - 0.00055 19.8 0.3 0.00093 19.1 0.3 1.3 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.20 KOO33682.1 - 0.00074 19.2 0.9 0.0016 18.2 0.5 1.6 2 0 0 2 2 2 1 Putative esterase Abhydrolase_5 PF12695.7 KOO33682.1 - 0.00098 18.9 0.1 0.0024 17.7 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 KOO33682.1 - 0.029 13.9 0.2 0.044 13.3 0.2 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF2974 PF11187.8 KOO33682.1 - 0.067 12.7 0.4 0.1 12.1 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 KOO33682.1 - 0.32 11.6 7.5 0.28 11.8 6.2 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF1970 PF09301.10 KOO33683.1 - 0.71 10.2 2.1 0.83 9.9 0.1 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1970) DUF3584 PF12128.8 KOO33683.1 - 5.2 4.4 60.8 1.4 6.4 9.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF2859 PF11072.8 KOO33683.1 - 8.6 6.1 10.7 0.077 12.7 1.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2859) DUF2188 PF09954.9 KOO33684.1 - 0.13 12.4 6.2 0.27 11.4 6.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) Borrelia_lipo_1 PF05714.11 KOO33684.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Lactamase_B PF00753.27 KOO33685.1 - 1e-18 68.1 0.5 2.1e-18 67.1 0.5 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Rhodanese PF00581.20 KOO33685.1 - 0.0028 18.2 0.0 0.0065 17.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Lactamase_B_2 PF12706.7 KOO33685.1 - 0.0046 16.5 0.4 0.014 14.9 0.4 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain PB1 PF00564.24 KOO33686.1 - 0.071 13.1 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 PB1 domain Lipase_GDSL_2 PF13472.6 KOO33687.1 - 0.026 14.9 0.0 0.032 14.6 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Mito_carr PF00153.27 KOO33688.1 - 1.9e-42 143.1 4.1 1.8e-15 56.7 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_13 PF17958.1 KOO33691.1 - 5.4e-21 74.2 0.1 1.2e-17 63.4 0.0 3.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 KOO33691.1 - 8.2e-13 48.6 4.9 3.1e-12 46.7 1.3 3.4 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO33691.1 - 1e-05 25.0 0.9 0.0015 18.3 0.2 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO33691.1 - 2.1e-05 23.7 0.3 0.03 13.9 0.1 3.6 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KOO33691.1 - 0.017 14.6 0.1 0.24 11.0 0.0 2.6 2 0 0 2 2 2 0 EF hand LRR_6 PF13516.6 KOO33692.1 - 1.3e-31 105.9 34.1 0.00051 19.9 0.1 14.2 16 0 0 16 16 16 10 Leucine Rich repeat LRR_4 PF12799.7 KOO33692.1 - 1.8e-08 34.5 8.3 6.7 7.3 0.3 9.6 2 1 11 13 13 13 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO33692.1 - 0.00064 19.9 20.6 26 5.9 0.0 10.7 10 3 1 11 11 11 2 Leucine Rich Repeat F-box PF00646.33 KOO33692.1 - 0.96 9.4 0.0 0.96 9.4 0.0 3.5 4 0 0 4 4 4 0 F-box domain La PF05383.17 KOO33693.1 - 1.2e-21 76.5 0.0 1.7e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 La domain DUF3223 PF11523.8 KOO33693.1 - 2e-18 67.0 0.0 4.1e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3223) RRM_3 PF08777.11 KOO33693.1 - 0.00066 19.7 0.1 0.0032 17.5 0.1 2.1 1 1 0 1 1 1 1 RNA binding motif GRP PF07172.11 KOO33693.1 - 0.89 10.3 29.9 3.7 8.3 18.6 2.6 2 0 0 2 2 2 0 Glycine rich protein family Cupin_4 PF08007.12 KOO33694.1 - 3.3e-59 200.9 0.0 5.5e-59 200.2 0.0 1.4 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_8 PF13621.6 KOO33694.1 - 0.014 15.1 0.1 0.074 12.8 0.1 2.0 1 1 0 1 1 1 0 Cupin-like domain AraC_binding PF02311.19 KOO33694.1 - 0.05 13.5 0.0 0.22 11.5 0.0 2.0 2 0 0 2 2 2 0 AraC-like ligand binding domain TPR_12 PF13424.6 KOO33695.1 - 1.4e-06 28.5 3.9 0.024 14.9 0.1 4.0 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO33695.1 - 0.013 15.4 4.8 0.015 15.1 0.8 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat LRR_6 PF13516.6 KOO33697.1 - 7.8e-46 150.3 57.2 0.00071 19.4 0.4 13.3 13 0 0 13 13 13 12 Leucine Rich repeat LRR_4 PF12799.7 KOO33697.1 - 8e-15 54.7 23.5 0.012 16.1 0.8 7.4 6 1 1 7 7 7 7 Leucine Rich repeats (2 copies) LRR_2 PF07723.13 KOO33697.1 - 5.3e-05 23.7 0.3 45 4.9 0.0 5.9 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO33697.1 - 1.4 8.8 47.1 11 5.9 0.8 10.3 1 1 11 12 12 12 0 Leucine rich repeat Arm-DNA-bind_1 PF09003.10 KOO33697.1 - 2.3 8.4 21.5 80 3.5 0.1 8.2 6 4 4 10 10 10 0 Bacteriophage lambda integrase, Arm DNA-binding domain FAD_oxidored PF12831.7 KOO33697.1 - 9.1 5.5 9.4 1.2e+02 1.9 0.1 4.4 5 0 0 5 5 5 0 FAD dependent oxidoreductase DUF2457 PF10446.9 KOO33698.1 - 3 6.9 7.6 3.1 6.8 7.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Filamin PF00630.19 KOO33699.1 - 9.2e-25 87.5 0.0 1.7e-05 25.6 0.0 4.5 4 0 0 4 4 4 4 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO33699.1 - 0.0061 16.8 5.9 0.11 12.9 0.0 4.1 5 1 0 5 5 5 1 Invasin, domain 3 SO_alpha_A3 PF17806.1 KOO33699.1 - 10 6.6 6.8 15 6.0 0.5 3.0 3 0 0 3 3 3 0 Sarcosine oxidase A3 domain EF-hand_1 PF00036.32 KOO33700.1 - 1.6e-15 55.4 2.3 5.4e-07 28.7 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO33700.1 - 2.4e-11 43.9 0.3 5.6e-11 42.7 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO33700.1 - 3.5e-11 42.1 0.3 4.4e-06 26.2 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO33700.1 - 1.3e-09 37.1 0.7 2e-05 23.8 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO33700.1 - 1.7e-08 34.2 2.4 6.3e-05 22.7 0.2 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO33700.1 - 0.00093 19.5 0.2 0.002 18.4 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO33700.1 - 0.0027 18.0 0.0 0.0027 18.0 0.0 3.5 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO33700.1 - 0.006 17.4 0.0 0.016 16.0 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO33700.1 - 0.0095 15.9 0.4 0.0095 15.9 0.4 2.3 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO33700.1 - 0.085 12.7 0.4 0.25 11.2 0.1 2.0 2 0 0 2 2 2 0 EF hand Arm PF00514.23 KOO33701.1 - 2.2e-05 24.3 7.0 0.0028 17.7 0.1 3.9 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat PCMT PF01135.19 KOO33702.1 - 2e-25 89.8 0.0 2.9e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOO33702.1 - 9.8e-09 35.2 0.0 2.1e-08 34.1 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO33702.1 - 0.00012 22.7 0.0 0.00045 20.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOO33702.1 - 0.001 19.1 0.0 0.002 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 KOO33702.1 - 0.0053 15.8 0.0 0.0078 15.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DOT1 PF08123.13 KOO33702.1 - 0.027 14.0 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_11 PF08241.12 KOO33702.1 - 0.04 14.6 0.0 0.2 12.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 KOO33702.1 - 0.046 13.3 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Pyrid_oxidase_2 PF13883.6 KOO33703.1 - 4.2e-46 157.0 0.0 7.9e-28 97.5 0.0 2.1 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase TetR_C_28 PF17937.1 KOO33703.1 - 0.016 15.7 0.1 4.2 7.9 0.0 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Beta_propel PF09826.9 KOO33704.1 - 4.4e-110 369.0 0.0 7.5e-93 312.1 0.0 2.0 1 1 0 2 2 2 2 Beta propeller domain SprB PF13573.6 KOO33704.1 - 0.35 10.7 0.1 0.35 10.7 0.1 3.1 3 0 0 3 3 3 0 SprB repeat Fanconi_C PF02106.15 KOO33705.1 - 0.066 11.9 3.7 0.11 11.1 3.7 1.3 1 0 0 1 1 1 0 Fanconi anaemia group C protein IL6 PF00489.17 KOO33705.1 - 0.084 12.4 1.6 0.1 12.2 0.5 1.7 2 1 0 2 2 2 0 Interleukin-6/G-CSF/MGF family LMBR1 PF04791.16 KOO33705.1 - 3.2 6.5 7.1 3.4 6.5 2.7 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein KxDL PF10241.9 KOO33705.1 - 5.3 7.4 18.4 0.57 10.5 3.1 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF1658 PF07871.11 KOO33707.1 - 1.1 9.3 4.4 5 7.2 1.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1658) Mon2_C PF16206.5 KOO33709.1 - 1.4e-38 132.7 0.1 1.4e-38 132.7 0.1 2.6 4 0 0 4 4 4 1 C-terminal region of Mon2 protein DCB PF16213.5 KOO33709.1 - 1.5e-30 106.2 4.6 1.9e-30 105.8 2.1 2.7 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 KOO33709.1 - 1.1e-27 96.9 0.0 1.2e-26 93.5 0.0 2.9 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 KOO33709.1 - 1.2e-13 50.7 0.2 9.7e-09 35.0 0.0 4.2 3 0 0 3 3 3 3 Domain of unknown function (DUF1981) Ribosomal_L5_C PF00673.21 KOO33710.1 - 2.1e-21 75.9 0.1 3.1e-21 75.3 0.1 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 KOO33710.1 - 6.7e-18 64.8 0.4 1.3e-17 63.9 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L5 FctA PF12892.7 KOO33710.1 - 0.036 14.9 0.0 0.044 14.6 0.0 1.2 1 0 0 1 1 1 0 Spy0128-like isopeptide containing domain Copper-fist PF00649.18 KOO33710.1 - 0.087 12.3 0.4 0.15 11.6 0.4 1.4 1 0 0 1 1 1 0 Copper fist DNA binding domain DUF4200 PF13863.6 KOO33711.1 - 2.1e-25 89.4 32.9 2.1e-25 89.4 32.9 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) DUF1664 PF07889.12 KOO33711.1 - 2.8 8.0 12.4 2.8 8.0 4.5 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) adh_short PF00106.25 KOO33712.1 - 5.4e-07 29.3 0.7 7e-06 25.6 0.7 2.1 1 1 0 1 1 1 1 short chain dehydrogenase Pyr_redox_3 PF13738.6 KOO33712.1 - 0.0093 15.2 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 KOO33712.1 - 0.097 13.1 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Glyco_transf_4 PF13439.6 KOO33712.1 - 0.13 12.2 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 3HCDH_N PF02737.18 KOO33712.1 - 0.17 11.7 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF218 PF02698.17 KOO33713.1 - 4.6e-15 55.8 0.0 7.3e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 DUF218 domain ASFV_J13L PF05568.11 KOO33714.1 - 5.1 6.8 9.3 0.62 9.8 1.5 2.4 2 0 0 2 2 2 0 African swine fever virus J13L protein LRR_6 PF13516.6 KOO33716.1 - 3.1e-27 92.3 44.3 0.00088 19.1 0.3 16.2 17 0 0 17 17 17 7 Leucine Rich repeat LRR_4 PF12799.7 KOO33716.1 - 2e-08 34.4 16.4 3 8.4 0.1 8.9 9 1 0 9 9 9 2 Leucine Rich repeats (2 copies) NACHT PF05729.12 KOO33716.1 - 7.3e-06 26.0 0.1 1.3e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 NACHT domain LRR_8 PF13855.6 KOO33716.1 - 9.4e-06 25.3 4.4 23 4.9 0.0 8.5 9 0 0 9 9 9 0 Leucine rich repeat LRR_1 PF00560.33 KOO33716.1 - 0.00011 22.2 11.8 65 4.7 0.0 10.3 14 0 0 14 14 10 0 Leucine Rich Repeat SASP PF00269.20 KOO33716.1 - 0.0052 16.8 1.5 11 6.1 0.0 4.2 4 0 0 4 4 4 1 Small, acid-soluble spore proteins, alpha/beta type RRM_1 PF00076.22 KOO33716.1 - 0.024 14.5 0.0 0.055 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_19 PF13245.6 KOO33716.1 - 0.081 13.3 0.1 0.21 11.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain ATP1G1_PLM_MAT8 PF02038.16 KOO33716.1 - 0.5 9.9 1.5 12 5.4 0.1 2.5 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family DUF5471 PF17565.2 KOO33716.1 - 0.67 10.3 3.5 12 6.3 0.8 3.3 2 0 0 2 2 2 0 Family of unknown function (DUF5471) AAA_16 PF13191.6 KOO33716.1 - 1.1 9.6 5.0 0.33 11.3 0.3 2.6 2 0 0 2 2 2 0 AAA ATPase domain DUF2853 PF11015.8 KOO33716.1 - 3.6 8.3 4.7 79 4.0 0.0 4.5 6 0 0 6 6 4 0 Protein of unknown function (DUF2853) DUF3149 PF11346.8 KOO33717.1 - 0.084 12.5 2.7 0.15 11.7 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) DUF4460 PF14687.6 KOO33718.1 - 0.0027 17.7 0.1 0.0039 17.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) tRNA-synt_1g PF09334.11 KOO33718.1 - 0.062 12.0 0.5 0.082 11.6 0.5 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (M) Peptidase_C74 PF12387.8 KOO33718.1 - 0.32 10.5 1.4 0.57 9.6 1.4 1.3 1 0 0 1 1 1 0 Pestivirus NS2 peptidase zf-ribbon_3 PF13248.6 KOO33718.1 - 0.54 9.7 4.4 15 5.1 0.3 2.0 1 1 0 2 2 2 0 zinc-ribbon domain YrhK PF14145.6 KOO33719.1 - 4.4e-07 29.7 29.7 0.0015 18.4 5.7 4.2 2 2 0 3 3 3 3 YrhK-like protein DUF3239 PF11580.8 KOO33721.1 - 0.062 13.6 0.0 0.067 13.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3239) adh_short PF00106.25 KOO33722.1 - 7.9e-09 35.2 0.2 6.1e-08 32.4 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO33722.1 - 1.9e-05 24.4 0.3 0.00058 19.5 0.0 2.0 1 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Aldedh PF00171.22 KOO33724.1 - 1.3e-152 508.5 0.2 1.5e-152 508.4 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 KOO33724.1 - 0.067 12.2 1.2 0.54 9.3 1.2 2.1 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF1542 PF07564.11 KOO33724.1 - 0.18 11.9 0.6 0.35 11.0 0.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) BT1 PF03092.16 KOO33727.1 - 2.5e-60 204.2 7.1 8.2e-33 113.4 0.4 2.4 3 0 0 3 3 3 2 BT1 family DUF1810 PF08837.11 KOO33728.1 - 2.4e-17 63.0 0.0 3e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1810) DUF1668 PF07893.13 KOO33728.1 - 0.053 12.9 0.1 0.072 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1668) Costars PF14705.6 KOO33728.1 - 0.17 12.1 0.0 0.44 10.8 0.0 1.6 1 0 0 1 1 1 0 Costars DHHC PF01529.20 KOO33729.1 - 1.3e-33 115.9 10.9 1.3e-33 115.9 10.9 2.7 2 1 0 2 2 2 1 DHHC palmitoyltransferase DNA_circ_N PF07157.12 KOO33729.1 - 0.13 12.7 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 DNA circularisation protein N-terminus Esterase PF00756.20 KOO33730.1 - 0.00029 20.6 0.5 0.00066 19.4 0.5 1.7 1 1 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 KOO33730.1 - 0.00038 20.0 0.3 0.0059 16.1 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KOO33730.1 - 0.027 14.1 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase PF07224.11 KOO33730.1 - 0.062 12.3 0.1 0.11 11.5 0.1 1.3 1 0 0 1 1 1 0 Chlorophyllase Abhydrolase_3 PF07859.13 KOO33730.1 - 0.087 12.7 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold RACo_linker PF17650.1 KOO33730.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 RACo linker region Chlorophyllase2 PF12740.7 KOO33730.1 - 0.19 10.6 0.2 0.39 9.6 0.0 1.5 2 0 0 2 2 2 0 Chlorophyllase enzyme Abhydrolase_2 PF02230.16 KOO33730.1 - 0.22 11.3 0.0 1.7 8.4 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Phage_int_SAM_5 PF13102.6 KOO33731.1 - 0.012 15.9 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 Phage integrase SAM-like domain PapD_C PF02753.17 KOO33732.1 - 0.034 14.5 0.0 0.5 10.7 0.0 2.3 2 0 0 2 2 2 0 Pili assembly chaperone PapD, C-terminal domain Lipase_3 PF01764.25 KOO33734.1 - 4.3e-23 81.7 0.0 7.9e-23 80.9 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 KOO33734.1 - 0.0001 21.7 0.3 0.00023 20.5 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO33734.1 - 0.00031 21.4 3.1 0.00031 21.4 3.1 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 KOO33734.1 - 0.0017 18.5 0.1 0.0047 17.1 0.1 1.7 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 KOO33734.1 - 0.025 14.2 0.1 0.049 13.3 0.1 1.4 1 0 0 1 1 1 0 Putative esterase DUF2974 PF11187.8 KOO33734.1 - 0.053 13.1 0.0 0.13 11.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) PGAP1 PF07819.13 KOO33734.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein MTHFR PF02219.17 KOO33735.1 - 1.6e-06 27.7 0.0 2.3e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF1289 PF06945.13 KOO33736.1 - 4.7e-05 23.1 17.4 3.9 7.4 0.1 7.4 4 3 5 9 9 9 3 Protein of unknown function (DUF1289) DUF2299 PF10061.9 KOO33736.1 - 0.00051 19.8 12.7 6 6.6 0.0 6.2 4 3 1 6 6 6 2 Uncharacterized conserved protein (DUF2299) HMG_box PF00505.19 KOO33736.1 - 0.0007 20.0 43.4 0.32 11.4 1.4 8.3 4 4 5 9 9 9 3 HMG (high mobility group) box DUF3106 PF11304.8 KOO33736.1 - 0.0013 19.1 26.9 0.06 13.8 4.0 5.3 4 1 0 4 4 3 3 Protein of unknown function (DUF3106) EF-hand_1 PF00036.32 KOO33736.1 - 0.0038 16.7 0.1 0.01 15.3 0.1 1.8 1 0 0 1 1 1 1 EF hand Catalase-rel PF06628.12 KOO33736.1 - 0.0056 16.9 8.6 23 5.3 0.0 6.9 4 4 2 7 7 7 0 Catalase-related immune-responsive EF-hand_6 PF13405.6 KOO33736.1 - 0.0083 16.0 0.1 0.023 14.6 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO33736.1 - 0.14 12.6 0.0 0.44 11.0 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair WHIM1 PF15612.6 KOO33736.1 - 0.19 11.3 0.0 29 4.4 0.0 3.5 4 0 0 4 4 4 0 WSTF, HB1, Itc1p, MBD9 motif 1 MgtE_N PF03448.17 KOO33736.1 - 0.45 11.2 21.1 2.8 8.6 1.2 4.9 4 1 1 5 5 5 0 MgtE intracellular N domain HSP9_HSP12 PF04119.12 KOO33736.1 - 0.57 10.6 0.0 0.57 10.6 0.0 3.1 3 1 0 3 3 2 0 Heat shock protein 9/12 PG_binding_3 PF09374.10 KOO33736.1 - 0.8 10.0 6.5 3.8 7.8 0.1 4.0 3 1 1 4 4 4 0 Predicted Peptidoglycan domain ParB_C PF18064.1 KOO33736.1 - 0.92 9.7 4.6 19 5.5 0.0 4.1 3 0 0 3 3 3 0 Centromere-binding protein ParB C-terminal DUF4473 PF14747.6 KOO33736.1 - 2.4 8.7 29.3 3.4 8.3 1.6 5.8 2 1 2 5 5 5 0 Domain of unknown function (DUF4473) TerB_N PF13208.6 KOO33736.1 - 3.1 7.5 5.1 12 5.6 0.8 3.7 3 2 0 3 3 3 0 TerB N-terminal domain COX4 PF02936.14 KOO33736.1 - 3.3 7.7 12.8 6.8 6.7 0.2 4.8 2 1 3 5 5 5 0 Cytochrome c oxidase subunit IV DUF1104 PF06518.11 KOO33736.1 - 3.4 8.1 26.9 3.7 8.0 0.7 5.4 4 1 0 4 4 4 0 Protein of unknown function (DUF1104) Ank_5 PF13857.6 KOO33737.1 - 1.1e-08 35.1 0.1 6.4e-08 32.7 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO33737.1 - 2.8e-08 34.2 0.2 6e-08 33.2 0.2 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33737.1 - 5e-07 30.2 0.0 1.6e-06 28.5 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33737.1 - 0.00068 19.9 0.0 0.011 16.2 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Rhabdo_glycop PF00974.18 KOO33737.1 - 0.0038 15.7 4.9 2.1 6.7 0.2 4.0 4 0 0 4 4 4 2 Rhabdovirus spike glycoprotein RPAP1_C PF08620.10 KOO33737.1 - 0.0061 16.6 29.3 43 4.3 0.7 12.8 9 4 1 10 10 10 0 RPAP1-like, C-terminal Ank PF00023.30 KOO33737.1 - 0.0065 16.9 0.1 0.087 13.3 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat GST_C_2 PF13410.6 KOO33737.1 - 0.037 14.0 5.4 3.1 7.9 0.1 4.2 4 0 0 4 4 4 0 Glutathione S-transferase, C-terminal domain Rootletin PF15035.6 KOO33737.1 - 0.072 13.1 10.8 0.11 12.5 10.8 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion MbeB_N PF04837.12 KOO33737.1 - 0.17 12.2 4.5 0.16 12.3 2.0 2.3 1 1 1 2 2 2 0 MbeB-like, N-term conserved region Apolipoprotein PF01442.18 KOO33737.1 - 0.21 11.5 16.4 0.34 10.8 16.4 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Ribosomal_L13e PF01294.18 KOO33737.1 - 2.1 8.1 27.6 9.1 6.1 0.1 9.6 5 2 6 11 11 11 0 Ribosomal protein L13e DUF1640 PF07798.11 KOO33737.1 - 3.6 7.6 8.0 11 6.0 6.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) DUF883 PF05957.13 KOO33737.1 - 6.2 7.5 10.9 4.9 7.8 6.9 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) WD40 PF00400.32 KOO33739.1 - 5e-39 131.6 17.1 5.7e-10 39.6 0.0 5.0 4 1 0 4 4 4 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO33739.1 - 5.9e-16 58.3 2.6 0.0037 16.3 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO33739.1 - 1.7e-13 50.7 1.0 0.00029 21.1 0.0 3.7 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO33739.1 - 1.2e-11 44.2 0.1 0.074 13.0 0.0 4.7 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat eIF2A PF08662.11 KOO33739.1 - 4.5e-10 39.7 0.1 2e-06 27.8 0.0 2.9 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 KOO33739.1 - 1.4e-06 27.0 0.1 0.052 11.9 0.0 2.9 1 1 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 KOO33739.1 - 4e-05 23.1 1.2 1.3 8.3 0.0 3.7 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 KOO33739.1 - 0.0029 17.0 0.3 0.12 11.6 0.2 2.2 1 1 1 2 2 2 1 WD40-like domain Plk4_PB1 PF18190.1 KOO33739.1 - 0.0047 17.1 0.5 20 5.4 0.0 3.8 1 1 3 4 4 4 0 Polo-like Kinase 4 Polo Box 1 WD40_3 PF15911.5 KOO33739.1 - 0.008 16.2 0.6 18 5.4 0.0 3.5 3 0 0 3 3 3 0 WD domain, G-beta repeat rOmpB PF12334.8 KOO33739.1 - 0.017 14.6 2.7 8.7 5.7 0.1 3.5 1 1 3 4 4 4 0 Rickettsia outer membrane protein B IKI3 PF04762.12 KOO33739.1 - 0.019 13.0 0.9 0.44 8.5 0.2 2.1 1 1 1 2 2 2 0 IKI3 family Proteasome_A_N PF10584.9 KOO33739.1 - 0.02 14.6 8.2 11 5.8 0.2 4.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Utp8 PF10395.9 KOO33739.1 - 0.021 13.4 0.1 0.44 9.0 0.0 1.9 1 1 1 2 2 2 0 Utp8 family Dfp1_Him1_M PF08630.10 KOO33739.1 - 0.13 12.5 1.6 43 4.3 0.0 3.3 3 1 0 3 3 3 0 Dfp1/Him1, central region Rdx PF10262.9 KOO33740.1 - 0.0008 19.5 0.0 0.0031 17.6 0.0 2.1 1 0 0 1 1 1 1 Rdx family CSTF1_dimer PF16699.5 KOO33740.1 - 0.23 11.2 1.0 2.4 8.0 0.0 3.0 3 0 0 3 3 3 0 Cleavage stimulation factor subunit 1, dimerisation domain PTCB-BRCT PF12738.7 KOO33742.1 - 0.00016 21.5 0.1 0.00025 20.9 0.1 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 KOO33742.1 - 0.00023 21.5 0.0 0.00033 21.0 0.0 1.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PRA-CH PF01502.18 KOO33743.1 - 7.9e-24 83.3 0.3 1.3e-23 82.6 0.3 1.3 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 KOO33743.1 - 1.6e-11 44.5 0.1 3.2e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase 2OG-FeII_Oxy_3 PF13640.6 KOO33743.1 - 2.8e-11 44.1 0.0 1.4e-10 41.9 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DNA_ligase_OB_2 PF14743.6 KOO33744.1 - 4.1e-22 78.0 0.1 6.6e-22 77.3 0.1 1.3 1 0 0 1 1 1 1 DNA ligase OB-like domain zf-CCHC PF00098.23 KOO33746.1 - 0.044 13.9 0.2 0.071 13.2 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle Abhydrolase_3 PF07859.13 KOO33747.1 - 1.2e-09 38.4 0.0 1.8e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold PDZ PF00595.24 KOO33747.1 - 1.6e-08 34.8 0.0 2.5e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO33747.1 - 3.7e-08 33.1 0.1 7e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO33747.1 - 0.00059 20.1 0.0 0.0009 19.5 0.0 1.3 1 0 0 1 1 1 1 PDZ domain zf-CCHC PF00098.23 KOO33748.1 - 0.037 14.1 0.2 0.062 13.4 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle Mem_trans PF03547.18 KOO33749.1 - 3.1e-08 32.4 9.3 1.3e-06 27.1 2.4 2.1 2 0 0 2 2 2 2 Membrane transport protein EF-hand_1 PF00036.32 KOO33750.1 - 7.9e-25 84.5 11.2 3.7e-05 23.0 0.0 6.2 5 1 1 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO33750.1 - 2.3e-23 82.4 9.5 2.7e-09 37.4 0.5 4.1 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO33750.1 - 8.9e-22 75.1 13.1 6.3e-05 22.6 0.0 6.2 5 1 1 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 KOO33750.1 - 1.3e-16 59.3 7.6 4.9e-06 25.8 0.0 5.5 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO33750.1 - 2.9e-11 43.0 8.4 0.00014 21.6 0.4 4.7 5 0 0 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO33750.1 - 0.00051 20.3 1.1 0.053 13.9 0.0 2.9 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO33750.1 - 0.0011 19.2 0.9 0.18 12.1 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain Armet PF10208.9 KOO33750.1 - 0.047 13.6 0.1 0.1 12.5 0.1 1.6 1 1 0 1 1 1 0 Degradation arginine-rich protein for mis-folding EF-hand_14 PF17959.1 KOO33750.1 - 0.063 13.6 0.8 2.5 8.5 0.0 3.0 1 1 1 3 3 3 0 EF-hand domain EF-hand_4 PF12763.7 KOO33750.1 - 0.16 12.0 1.6 0.86 9.6 0.4 2.7 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO33750.1 - 1.2 9.4 6.4 2.3 8.4 0.1 3.5 2 2 1 3 3 3 0 Dockerin type I domain DUF2181 PF10223.9 KOO33751.1 - 1.2e-40 139.6 0.0 1.6e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) ABC_tran_CTD PF16326.5 KOO33751.1 - 0.25 11.6 1.0 24 5.3 0.0 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain EF-hand_1 PF00036.32 KOO33752.1 - 4e-52 169.9 19.0 7.2e-05 22.1 0.0 12.7 11 2 2 13 13 13 11 EF hand EF-hand_6 PF13405.6 KOO33752.1 - 7.3e-45 147.1 28.0 0.00012 21.7 0.0 12.4 10 2 2 12 12 12 10 EF-hand domain EF-hand_7 PF13499.6 KOO33752.1 - 7.6e-44 148.0 23.4 1.1e-09 38.6 0.4 8.5 6 3 2 8 8 8 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO33752.1 - 2e-35 118.7 18.9 2.2e-05 23.7 0.0 11.4 12 0 0 12 12 12 8 EF hand EF-hand_8 PF13833.6 KOO33752.1 - 7.6e-25 86.5 13.5 0.00011 21.9 0.1 9.6 11 0 0 11 11 10 6 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO33752.1 - 3.4e-08 33.8 5.7 0.74 10.2 0.0 5.4 5 1 1 6 6 6 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO33752.1 - 5.1e-07 29.9 3.7 0.8 10.1 0.0 5.9 6 0 0 6 6 6 1 EF-hand domain Caleosin PF05042.13 KOO33752.1 - 0.0001 22.3 2.1 11 5.9 0.0 6.3 5 1 1 7 7 7 1 Caleosin related protein Dockerin_1 PF00404.18 KOO33752.1 - 0.0029 17.8 12.0 2.1 8.6 0.0 5.8 6 2 1 7 7 7 2 Dockerin type I domain EF-hand_14 PF17959.1 KOO33752.1 - 0.069 13.5 2.7 15 6.0 0.0 4.8 5 1 0 5 5 5 0 EF-hand domain TM231 PF10149.9 KOO33752.1 - 0.09 12.1 1.6 2.7 7.2 0.0 3.1 2 1 0 3 3 3 0 Transmembrane protein 231 Armet PF10208.9 KOO33752.1 - 0.091 12.7 0.1 0.28 11.1 0.1 1.8 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding GPHH PF16905.5 KOO33752.1 - 0.18 11.6 0.1 62 3.5 0.0 4.3 5 0 0 5 5 5 0 Voltage-dependent L-type calcium channel, IQ-associated Phage_NinH PF06322.11 KOO33752.1 - 0.76 9.7 2.2 7.5 6.5 0.3 3.0 3 0 0 3 3 3 0 Phage NinH protein Glyco_hydro_28 PF00295.17 KOO33753.1 - 9.3e-32 110.4 0.1 3.5e-16 59.2 0.1 3.1 3 0 0 3 3 3 3 Glycosyl hydrolases family 28 Beta_helix PF13229.6 KOO33753.1 - 0.022 14.6 0.0 19 5.1 0.0 3.6 2 2 1 3 3 3 0 Right handed beta helix region Filamin PF00630.19 KOO33754.1 - 9.5e-09 36.0 0.1 6.5e-07 30.1 0.1 2.4 2 0 0 2 2 2 1 Filamin/ABP280 repeat Big_1 PF02369.16 KOO33754.1 - 0.00054 19.9 0.0 0.0033 17.4 0.0 2.3 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) CarboxypepD_reg PF13620.6 KOO33754.1 - 0.028 14.7 0.0 0.09 13.1 0.0 1.9 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Invasin_D3 PF09134.10 KOO33754.1 - 0.03 14.6 0.0 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 Invasin, domain 3 Coprogen_oxidas PF01218.18 KOO33755.1 - 5.5e-85 284.7 0.0 6.7e-85 284.4 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase PDEase_I PF00233.19 KOO33756.1 - 4.8e-84 281.8 3.0 1.7e-56 191.7 0.0 3.0 2 1 1 3 3 3 3 3'5'-cyclic nucleotide phosphodiesterase DUF1011 PF06237.12 KOO33756.1 - 0.00013 22.2 0.4 0.65 10.4 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1011) RyR PF02026.16 KOO33756.1 - 0.049 13.8 0.3 16 5.8 0.0 2.5 2 0 0 2 2 2 0 RyR domain Methyltransf_32 PF13679.6 KOO33757.1 - 4.8e-13 49.4 0.2 8.2e-13 48.6 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 KOO33757.1 - 0.01 15.5 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.6 KOO33757.1 - 0.014 16.1 0.0 0.044 14.5 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KOO33757.1 - 0.015 15.1 0.0 0.035 13.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.13 KOO33757.1 - 0.17 11.4 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 LuxE PF04443.12 KOO33759.1 - 0.12 11.4 0.1 0.12 11.4 0.1 1.1 1 0 0 1 1 1 0 Acyl-protein synthetase, LuxE DUF4449 PF14613.6 KOO33759.1 - 0.17 12.0 2.5 0.2 11.7 2.4 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4449) DUF349 PF03993.12 KOO33760.1 - 2.3 8.6 7.1 0.2 12.0 1.4 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) LRR_6 PF13516.6 KOO33761.1 - 6.8e-11 41.3 45.1 0.03 14.4 0.1 13.3 13 0 0 13 13 13 5 Leucine Rich repeat LRR_1 PF00560.33 KOO33761.1 - 4.4e-08 32.6 10.4 14 6.7 0.0 9.2 10 0 0 10 10 8 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO33761.1 - 3.1e-07 30.0 10.9 27 4.6 0.0 8.9 8 1 0 8 8 8 0 Leucine rich repeat LRR_4 PF12799.7 KOO33761.1 - 2.9e-05 24.3 17.6 7 7.2 0.0 8.7 8 1 0 8 8 8 1 Leucine Rich repeats (2 copies) DprA_WH PF17782.1 KOO33761.1 - 0.0012 19.0 3.9 5.3 7.2 0.1 4.9 5 0 0 5 5 5 1 DprA winged helix domain FIBP PF05427.11 KOO33761.1 - 0.0016 17.8 0.3 5 6.3 0.0 3.6 4 0 0 4 4 4 1 Acidic fibroblast growth factor binding (FIBP) SLT_L PF14718.6 KOO33761.1 - 0.002 18.2 0.1 92 3.3 0.0 4.4 4 0 0 4 4 4 0 Soluble lytic murein transglycosylase L domain Mesd PF10185.9 KOO33761.1 - 0.0056 16.6 0.0 34 4.3 0.0 3.7 4 0 0 4 4 4 0 Chaperone for wingless signalling and trafficking of LDL receptor ATP-synt_10 PF05176.14 KOO33761.1 - 0.013 14.7 0.0 14 4.9 0.0 3.7 4 0 0 4 4 4 0 ATP10 protein UPF0181 PF03701.14 KOO33761.1 - 0.019 14.6 3.9 31 4.3 0.1 5.2 5 0 0 5 5 5 0 Uncharacterised protein family (UPF0181) Skp1 PF01466.19 KOO33761.1 - 0.054 13.6 0.0 0.3 11.2 0.0 2.3 2 0 0 2 2 2 0 Skp1 family, dimerisation domain Beach PF02138.18 KOO33762.1 - 1.4e-95 319.8 0.0 1.9e-95 319.4 0.0 1.1 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 KOO33762.1 - 3.2e-06 27.2 0.0 6.2e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 KOO33762.1 - 6.3e-06 26.8 2.6 0.78 10.7 0.0 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat Ion_trans_2 PF07885.16 KOO33763.1 - 7.3e-14 51.5 9.8 1.1e-13 50.9 8.0 2.3 2 0 0 2 2 2 1 Ion channel Ank_2 PF12796.7 KOO33763.1 - 8.9e-13 48.6 1.1 1.6e-09 38.2 0.6 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33763.1 - 2e-12 47.3 0.6 8.9e-08 32.5 0.1 4.2 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO33763.1 - 2.6e-12 46.7 3.4 1.5e-06 28.4 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33763.1 - 5.7e-09 35.5 1.0 0.091 13.4 0.0 4.3 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KOO33763.1 - 2.3e-07 30.9 5.8 0.029 14.8 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat DUF1418 PF07214.12 KOO33763.1 - 0.0066 16.3 0.1 0.018 14.9 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1418) EF-hand_7 PF13499.6 KOO33763.1 - 0.14 12.7 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair DWNN PF08783.11 KOO33764.1 - 3.6e-21 75.2 0.1 5.1e-21 74.7 0.1 1.2 1 0 0 1 1 1 1 DWNN domain DUF4704 PF15787.5 KOO33766.1 - 0.0074 15.6 0.3 0.061 12.6 0.2 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4704) SAM_1 PF00536.30 KOO33767.1 - 0.046 14.2 0.5 0.35 11.4 0.5 2.1 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) Ribosomal_S5_C PF03719.15 KOO33768.1 - 3.6e-17 61.6 0.0 9.7e-17 60.2 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 KOO33768.1 - 1e-13 51.0 2.4 2e-13 50.1 2.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain PPR_2 PF13041.6 KOO33769.1 - 3e-48 161.8 0.0 9.6e-12 44.9 0.0 8.2 3 1 6 9 9 9 9 PPR repeat family PPR_1 PF12854.7 KOO33769.1 - 2.4e-41 139.1 7.1 5.5e-07 29.2 0.0 10.0 11 0 0 11 11 11 8 PPR repeat PPR PF01535.20 KOO33769.1 - 2.7e-37 124.4 0.9 3.9e-05 23.6 0.0 11.0 12 0 0 12 12 12 7 PPR repeat PPR_3 PF13812.6 KOO33769.1 - 2.5e-23 81.9 0.0 2.5e-08 33.9 0.0 6.3 2 2 4 7 7 7 5 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO33769.1 - 1.7e-16 60.2 0.0 1.3e-08 34.5 0.0 3.9 1 1 3 4 4 4 4 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 KOO33769.1 - 2.7e-05 24.6 2.1 3.3 8.3 0.0 4.8 5 1 1 6 6 6 2 Tetratricopeptide repeat ATP13 PF12921.7 KOO33769.1 - 0.0042 16.9 0.0 12 5.8 0.0 4.0 3 1 1 4 4 4 1 Mitochondrial ATPase expression TPR_14 PF13428.6 KOO33769.1 - 0.0059 17.3 17.6 4 8.5 0.4 7.5 4 1 5 9 9 9 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO33769.1 - 0.055 14.1 4.8 41 5.2 0.6 5.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO33769.1 - 0.082 13.1 0.2 33 4.9 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO33769.1 - 0.13 12.9 8.6 3.6 8.3 0.0 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat Meckelin PF09773.9 KOO33771.1 - 3.2e-155 518.4 0.3 1.1e-107 361.2 0.0 3.0 3 0 0 3 3 3 3 Meckelin (Transmembrane protein 67) S-AdoMet_synt_C PF02773.16 KOO33771.1 - 0.078 13.0 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, C-terminal domain Melibiase_2 PF16499.5 KOO33773.1 - 2.3e-14 53.3 0.1 3.2e-14 52.8 0.1 1.1 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 KOO33773.1 - 2.2e-09 37.3 0.1 2.6e-08 33.8 0.1 2.4 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain HC2 PF07382.11 KOO33774.1 - 0.00015 21.9 32.8 0.00019 21.5 32.8 1.2 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 MCPVI PF02993.14 KOO33774.1 - 9.4 6.0 9.6 6.5 6.5 8.4 1.3 1 1 0 1 1 1 0 Minor capsid protein VI PDZ_6 PF17820.1 KOO33775.1 - 5.5e-08 32.5 1.1 4.1e-06 26.5 0.1 2.8 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO33775.1 - 1.4e-05 25.4 0.0 0.015 15.6 0.0 3.5 3 0 0 3 3 3 1 PDZ domain PDZ PF00595.24 KOO33775.1 - 0.00014 22.2 0.0 0.00052 20.3 0.0 1.9 2 0 0 2 2 2 1 PDZ domain Tudor_2 PF18104.1 KOO33775.1 - 0.16 11.7 0.2 0.46 10.2 0.2 1.8 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain UBA PF00627.31 KOO33776.1 - 1.5e-11 43.9 0.7 3.1e-11 42.9 0.7 1.6 1 0 0 1 1 1 1 UBA/TS-N domain DUF3327 PF11806.8 KOO33776.1 - 0.0085 16.8 0.1 5.6 7.7 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3327) PD40 PF07676.12 KOO33776.1 - 0.061 13.3 1.9 5.3 7.1 0.1 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Ntox21 PF15526.6 KOO33776.1 - 0.15 12.4 0.0 10 6.5 0.0 2.9 2 0 0 2 2 2 0 Novel toxin 21 Glyco_hydro_32N PF00251.20 KOO33776.1 - 0.31 10.6 2.2 14 5.1 0.5 2.2 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain Phage_lysis PF03245.13 KOO33776.1 - 0.7 10.0 5.2 5.3 7.2 0.4 2.8 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein bZIP_1 PF00170.21 KOO33776.1 - 2.1 8.5 6.2 0.25 11.5 0.8 2.2 3 0 0 3 3 3 0 bZIP transcription factor Cnn_1N PF07989.11 KOO33776.1 - 2.4 8.4 8.9 3 8.0 0.7 3.1 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 YabA PF06156.13 KOO33776.1 - 3.6 8.3 7.6 3 8.5 0.8 3.2 2 1 1 3 3 3 0 Initiation control protein YabA Spc24 PF08286.11 KOO33776.1 - 8.2 6.7 10.5 2.7 8.3 0.1 3.2 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 PsbN PF02468.15 KOO33777.1 - 0.16 11.8 0.3 0.71 9.8 0.0 2.3 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) PP2C PF00481.21 KOO33779.1 - 2.4e-29 102.7 0.0 3.1e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C DEAD PF00270.29 KOO33780.1 - 3.2e-15 56.3 0.0 5.4e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO33780.1 - 1.5e-06 28.6 0.0 1.7e-05 25.2 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain MRP-S33 PF08293.11 KOO33780.1 - 0.043 14.0 0.1 17 5.7 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial ribosomal subunit S27 XLF PF09302.11 KOO33780.1 - 0.079 13.1 0.0 3.1 7.9 0.0 2.3 2 0 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component CMS1 PF14617.6 KOO33780.1 - 0.096 12.0 0.0 0.096 12.0 0.0 2.2 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit DHQS PF01959.16 KOO33781.1 - 5.5e-66 222.9 0.3 3.7e-60 203.7 0.1 2.0 1 1 1 2 2 2 2 3-dehydroquinate synthase II Hint PF01079.20 KOO33781.1 - 0.0059 16.1 0.0 0.04 13.4 0.0 2.2 3 0 0 3 3 3 1 Hint module LRR_8 PF13855.6 KOO33782.1 - 1.7e-06 27.7 0.8 1.7e-06 27.7 0.8 2.0 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 KOO33782.1 - 1.1e-05 25.6 5.8 0.0011 19.4 0.4 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) DUF2976 PF11190.8 KOO33782.1 - 0.078 12.8 0.1 0.078 12.8 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) DUF4083 PF13314.6 KOO33782.1 - 0.22 11.5 5.1 0.13 12.2 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) DUF3165 PF11364.8 KOO33782.1 - 6.3 7.2 6.1 2.4 8.6 2.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3165) Cellulase PF00150.18 KOO33783.1 - 7.4e-09 35.4 0.0 0.003 17.0 0.3 2.1 1 1 1 2 2 2 2 Cellulase (glycosyl hydrolase family 5) tRNA-synt_2b PF00587.25 KOO33784.1 - 4e-34 118.1 0.0 6.2e-34 117.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 KOO33784.1 - 8.3e-25 87.1 1.8 8.3e-25 87.1 1.8 2.9 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain Dpy-30 PF05186.13 KOO33784.1 - 1.6e-06 27.7 0.1 3.1e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Dpy-30 motif PEARLI-4 PF05278.12 KOO33784.1 - 1.6 8.3 10.6 0.47 10.0 1.0 2.4 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) CCDC53 PF10152.9 KOO33784.1 - 8 6.9 7.7 4 7.8 4.0 2.0 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex COX15-CtaA PF02628.15 KOO33785.1 - 0.18 10.8 0.0 0.18 10.8 0.0 1.0 1 0 0 1 1 1 0 Cytochrome oxidase assembly protein Nucleotid_trans PF03407.16 KOO33787.1 - 1.4e-36 126.5 0.1 2e-36 126.0 0.1 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase O-FucT PF10250.9 KOO33787.1 - 0.0054 16.5 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase EF-hand_1 PF00036.32 KOO33788.1 - 1.9e-19 67.6 3.4 7e-06 25.2 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO33788.1 - 5.8e-17 60.1 5.3 3.2e-06 26.6 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 KOO33788.1 - 2.5e-16 59.9 0.2 2.2e-07 31.2 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO33788.1 - 2.1e-11 43.5 3.9 0.00023 20.9 0.0 4.1 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO33788.1 - 5.8e-09 35.0 7.9 0.0019 17.6 0.1 4.0 4 0 0 4 4 4 3 EF hand PUA PF01472.20 KOO33789.1 - 1e-15 57.4 0.0 1.3e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 PUA domain Pre-PUA PF17832.1 KOO33789.1 - 2.5e-09 37.7 0.1 3.5e-09 37.2 0.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain DNA_meth_N PF18284.1 KOO33790.1 - 0.081 12.8 0.1 0.29 11.1 0.1 1.9 1 0 0 1 1 1 0 DNA methylase N-terminal domain Methyltransf_21 PF05050.12 KOO33791.1 - 3.5e-05 23.9 0.0 7.2e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase FkbM domain cNMP_binding PF00027.29 KOO33793.1 - 5.8e-21 74.4 1.3 1e-09 38.3 1.2 5.3 4 1 0 4 4 4 3 Cyclic nucleotide-binding domain Ion_trans PF00520.31 KOO33793.1 - 6.6e-12 45.2 12.0 9.8e-08 31.5 3.1 2.3 2 0 0 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 KOO33793.1 - 9e-05 22.4 1.4 9e-05 22.4 1.4 2.7 2 0 0 2 2 2 1 Ion channel DUF3597 PF12200.8 KOO33794.1 - 0.04 14.5 0.2 0.082 13.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) Serglycin PF04360.12 KOO33795.1 - 0.078 12.9 1.0 0.12 12.4 1.0 1.3 1 0 0 1 1 1 0 Serglycin MSP1_C PF07462.11 KOO33795.1 - 0.13 11.0 1.8 0.14 10.9 1.8 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Peptidase_M50 PF02163.22 KOO33796.1 - 1.5e-32 112.9 0.0 5e-32 111.2 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M50 PDZ PF00595.24 KOO33796.1 - 4.4e-06 27.0 0.0 1.2e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO33796.1 - 1.8e-05 24.5 0.0 4.3e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO33796.1 - 0.00064 20.0 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Neur_chan_LBD PF02931.23 KOO33797.1 - 0.18 11.2 0.1 0.18 11.2 0.1 2.2 3 1 1 4 4 4 0 Neurotransmitter-gated ion-channel ligand binding domain TMEM171 PF15471.6 KOO33797.1 - 3.3 6.6 4.6 3.4 6.6 0.5 2.1 1 1 1 2 2 2 0 Transmembrane protein family 171 Agenet PF05641.12 KOO33798.1 - 2.6e-07 31.0 5.5 0.0052 17.2 0.0 4.0 5 0 0 5 5 5 2 Agenet domain Arm PF00514.23 KOO33799.1 - 2.9e-31 106.5 28.2 3.1e-05 23.9 0.0 8.4 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat DsrH PF04077.12 KOO33799.1 - 0.0071 16.5 5.9 7.4 6.8 0.1 4.4 1 1 1 2 2 2 1 DsrH like protein Nif11 PF07862.11 KOO33799.1 - 0.025 14.9 3.5 29 5.1 0.1 4.2 4 0 0 4 4 4 0 Nif11 domain EF-hand_14 PF17959.1 KOO33799.1 - 0.14 12.5 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain DSPc PF00782.20 KOO33800.1 - 3.8e-17 62.3 0.0 6.6e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PDZ PF00595.24 KOO33801.1 - 6.3e-07 29.7 0.1 1.1e-06 28.9 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO33801.1 - 6e-06 26.0 0.0 1.5e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO33801.1 - 2.3e-05 24.7 0.1 5.7e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 PDZ domain Bax1-I PF01027.20 KOO33801.1 - 1.4 8.7 7.7 0.3 10.9 3.9 1.8 2 1 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 Ammonium_transp PF00909.21 KOO33802.1 - 5.7e-58 196.5 8.3 6.7e-58 196.3 8.3 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family Polysacc_synt_C PF14667.6 KOO33802.1 - 5.7 7.0 15.2 0.33 11.0 8.6 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain Ank_2 PF12796.7 KOO33803.1 - 4.1e-71 235.6 22.0 1.4e-13 51.2 1.9 6.3 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33803.1 - 9.5e-51 169.6 19.9 1.3e-09 38.4 0.1 8.0 6 3 2 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO33803.1 - 8.7e-43 143.8 27.1 1.8e-07 31.3 0.1 10.5 1 1 8 10 10 10 10 Ankyrin repeats (many copies) Ank PF00023.30 KOO33803.1 - 2.7e-37 125.6 48.7 6.8e-05 23.1 0.2 11.6 11 0 0 11 11 11 11 Ankyrin repeat Ank_3 PF13606.6 KOO33803.1 - 3.2e-31 103.9 29.0 0.0016 18.8 0.0 11.9 12 0 0 12 12 12 10 Ankyrin repeat SR1P PF13790.6 KOO33803.1 - 2.9e-05 24.1 2.3 4.9 7.3 0.0 5.9 6 0 0 6 6 6 2 SR1 protein Prok-RING_1 PF14446.6 KOO33803.1 - 0.043 13.8 21.0 2.5 8.1 0.3 6.2 6 1 1 7 7 7 0 Prokaryotic RING finger family 1 GST_N_5 PF18485.1 KOO33803.1 - 6.7 7.1 13.6 29 5.1 0.2 7.0 8 1 1 9 9 9 0 Glutathione S-transferase, N-terminal domain FAD_binding_3 PF01494.19 KOO33804.1 - 1.2e-11 44.4 1.3 1.8e-11 43.9 1.3 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KOO33804.1 - 0.00044 20.4 1.8 0.001 19.3 1.8 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOO33804.1 - 0.00046 20.2 1.2 0.18 11.8 0.8 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 KOO33804.1 - 0.0014 17.9 1.6 0.097 11.9 1.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 KOO33804.1 - 0.0044 16.4 0.0 0.0071 15.7 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 KOO33804.1 - 0.013 15.1 3.2 0.013 15.1 3.2 2.2 1 1 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOO33804.1 - 0.25 11.9 1.3 1 10.0 1.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KOO33804.1 - 0.68 8.9 2.1 8.4 5.3 0.5 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein P66_CC PF16563.5 KOO33806.1 - 0.33 10.6 2.0 0.37 10.5 0.2 2.0 2 0 0 2 2 2 0 Coiled-coil and interaction region of P66A and P66B with MBD2 Complex1_LYR PF05347.15 KOO33807.1 - 3e-09 36.8 0.0 4.7e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOO33807.1 - 0.027 15.2 0.1 0.035 14.8 0.1 1.2 1 0 0 1 1 1 0 Complex1_LYR-like DUF1664 PF07889.12 KOO33808.1 - 1.7 8.7 18.2 0.81 9.7 2.4 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Neurensin PF14927.6 KOO33809.1 - 0.48 10.1 1.8 4.5 7.0 0.1 2.5 1 1 2 3 3 3 0 Neurensin WD40 PF00400.32 KOO33810.1 - 4.7e-36 122.2 6.5 4.7e-09 36.7 0.0 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO33810.1 - 4.4e-18 65.4 0.0 1.7e-06 28.3 0.0 4.6 1 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 KOO33810.1 - 5e-12 45.2 0.3 1e-11 44.2 0.3 1.6 1 0 0 1 1 1 1 LisH-like dimerisation domain Ge1_WD40 PF16529.5 KOO33810.1 - 1.6e-08 33.9 0.4 0.29 10.1 0.0 4.0 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 KOO33810.1 - 0.002 18.6 0.3 2.5 8.7 0.1 3.2 3 0 0 3 3 3 2 PQQ-like domain Nup160 PF11715.8 KOO33810.1 - 0.021 13.5 0.0 0.4 9.2 0.0 2.3 2 0 0 2 2 2 0 Nucleoporin Nup120/160 PD40 PF07676.12 KOO33810.1 - 0.026 14.5 0.0 0.45 10.5 0.0 2.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat HPS6 PF15702.5 KOO33810.1 - 0.13 10.2 0.0 0.21 9.5 0.0 1.2 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 6 protein SBP_bac_3 PF00497.20 KOO33810.1 - 0.16 11.3 0.1 0.34 10.3 0.1 1.6 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Myb_DNA-binding PF00249.31 KOO33812.1 - 2.2e-34 117.4 3.6 2.5e-16 59.6 0.4 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO33812.1 - 1.6e-22 79.5 1.0 2.3e-14 53.4 0.0 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO33812.1 - 0.015 15.2 0.0 0.12 12.3 0.0 2.1 1 1 1 2 2 2 0 Myb DNA-binding like SLIDE PF09111.10 KOO33812.1 - 0.11 12.5 0.0 3.1 7.9 0.0 2.2 1 1 1 2 2 2 0 SLIDE DUF2475 PF10629.9 KOO33814.1 - 0.00028 21.0 16.4 0.065 13.4 0.2 4.7 4 0 0 4 4 4 3 Protein of unknown function (DUF2475) DUF563 PF04577.14 KOO33815.1 - 4.1e-11 43.4 0.1 9.5e-11 42.2 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF563) NAPRTase_N PF17767.1 KOO33816.1 - 0.0024 18.2 0.4 0.0062 16.9 0.0 1.9 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain ETF PF01012.21 KOO33817.1 - 1.1e-47 162.2 3.3 1.5e-47 161.8 3.3 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain EIIBC-GUT_C PF07663.11 KOO33817.1 - 0.028 14.6 0.0 0.54 10.4 0.0 2.3 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II C-terminus Epimerase PF01370.21 KOO33819.1 - 1.3e-50 172.2 0.0 2.2e-50 171.4 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO33819.1 - 8.6e-47 160.1 0.0 1.7e-46 159.2 0.0 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Calpain_III PF01067.22 KOO33819.1 - 1.7e-15 57.6 0.0 0.00023 21.4 0.0 4.8 4 1 0 4 4 4 3 Calpain large subunit, domain III 3Beta_HSD PF01073.19 KOO33819.1 - 4.9e-11 42.2 0.0 8.9e-11 41.3 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KOO33819.1 - 3.9e-09 36.0 0.0 6.8e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain EF-hand_1 PF00036.32 KOO33819.1 - 0.00012 21.4 0.0 0.74 9.5 0.0 2.8 2 0 0 2 2 2 2 EF hand adh_short PF00106.25 KOO33819.1 - 0.0028 17.1 0.0 0.0078 15.7 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 KOO33819.1 - 0.0096 15.5 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 KOO33819.1 - 0.087 12.7 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 KR domain EF-hand_7 PF13499.6 KOO33819.1 - 0.2 12.2 0.1 11 6.6 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_8 PF13833.6 KOO33820.1 - 2.5e-06 27.2 0.0 4.6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO33820.1 - 5.1e-06 25.7 0.0 9.8e-06 24.8 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO33820.1 - 0.0006 19.2 0.0 0.001 18.5 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO33820.1 - 0.00072 19.9 0.0 0.0013 19.1 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO33820.1 - 0.0064 16.3 0.0 0.021 14.7 0.0 1.8 1 1 1 2 2 2 1 EF-hand domain DUF1126 PF06565.12 KOO33821.1 - 3.4e-08 33.3 0.0 9.8e-08 31.8 0.0 1.7 1 1 0 1 1 1 1 DUF1126 PH-like domain Dak1_2 PF13684.6 KOO33821.1 - 2.6 7.0 7.0 3.8 6.5 7.0 1.1 1 0 0 1 1 1 0 Dihydroxyacetone kinase family UNC-93 PF05978.16 KOO33822.1 - 3.3e-12 46.4 6.9 5.5e-12 45.7 6.3 1.7 1 1 1 2 2 2 1 Ion channel regulatory protein UNC-93 DUF4246 PF14033.6 KOO33823.1 - 0.022 13.9 0.0 0.024 13.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4246) Pkinase PF00069.25 KOO33824.1 - 1.7e-55 188.3 0.0 3.2e-55 187.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO33824.1 - 2.4e-31 107.6 1.1 1.8e-15 56.8 0.1 3.1 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO33824.1 - 1.3e-26 93.5 0.0 2e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO33824.1 - 0.0013 18.1 0.0 0.0022 17.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like GRAM PF02893.20 KOO33824.1 - 0.0015 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 GRAM domain IRK_C PF17655.1 KOO33824.1 - 0.06 13.0 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Inward rectifier potassium channel C-terminal domain APH PF01636.23 KOO33824.1 - 0.14 12.1 1.9 1.3 8.9 0.0 3.2 4 0 0 4 4 4 0 Phosphotransferase enzyme family LBR_tudor PF09465.10 KOO33825.1 - 1.1e-13 50.8 0.1 0.0023 17.7 0.0 3.6 4 0 0 4 4 4 3 Lamin-B receptor of TUDOR domain Agenet PF05641.12 KOO33825.1 - 5.3e-07 30.0 0.0 0.013 16.0 0.0 3.3 3 0 0 3 3 3 2 Agenet domain 53-BP1_Tudor PF09038.10 KOO33825.1 - 0.00044 20.2 0.0 0.14 12.1 0.0 3.1 3 0 0 3 3 3 1 Tumour suppressor p53-binding protein-1 Tudor Tudor_3 PF18115.1 KOO33825.1 - 0.003 17.4 0.0 2 8.3 0.0 2.7 3 0 0 3 3 3 2 DNA repair protein Crb2 Tudor domain SMN PF06003.12 KOO33825.1 - 0.0037 16.6 0.0 0.46 9.7 0.0 2.6 3 0 0 3 3 3 1 Survival motor neuron protein (SMN) Rad9_Rad53_bind PF08605.10 KOO33825.1 - 0.018 15.3 0.0 1.7 8.8 0.0 2.9 2 1 1 3 3 3 0 Fungal Rad9-like Rad53-binding EF-hand_7 PF13499.6 KOO33825.1 - 0.022 15.2 0.1 0.043 14.3 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO33825.1 - 0.026 14.5 0.0 0.17 11.9 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 KOO33825.1 - 0.082 12.5 0.0 0.46 10.2 0.0 2.3 2 0 0 2 2 2 0 EF hand ABC_membrane PF00664.23 KOO33826.1 - 1.4e-20 74.1 0.8 1.7e-20 73.8 0.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region Pkinase PF00069.25 KOO33827.1 - 5.2e-73 245.6 0.0 6.9e-73 245.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33827.1 - 4.9e-49 167.0 0.0 7.4e-49 166.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KOO33827.1 - 2.4e-07 31.2 0.1 5.2e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 KOO33827.1 - 3.8e-07 29.2 0.0 6.4e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO33827.1 - 0.00057 19.3 0.0 0.0036 16.6 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KOO33827.1 - 0.031 13.6 0.1 0.066 12.6 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO33827.1 - 0.062 13.2 2.0 0.35 10.8 0.0 2.5 2 1 0 3 3 3 0 Phosphotransferase enzyme family Gly-zipper_OmpA PF13436.6 KOO33827.1 - 2.1 8.2 12.2 1.9e+02 1.9 12.2 2.6 1 1 0 1 1 1 0 Glycine-zipper domain E1-E2_ATPase PF00122.20 KOO33828.1 - 1.8e-47 161.2 0.0 3.6e-47 160.2 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KOO33828.1 - 1e-39 136.2 0.0 2.1e-39 135.1 0.0 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 KOO33828.1 - 5.8e-18 64.8 0.0 1e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOO33828.1 - 8.4e-17 62.2 8.6 1.5e-15 58.1 6.7 3.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOO33828.1 - 4.5e-12 45.5 0.0 9.2e-12 44.5 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOO33828.1 - 2.6e-05 24.1 1.6 2.8e-05 24.0 0.6 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DSPc PF00782.20 KOO33829.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DUF3431 PF11913.8 KOO33830.1 - 7.2e-16 58.6 0.0 1.1e-15 58.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) LRR_6 PF13516.6 KOO33831.1 - 9.8e-09 34.6 0.1 0.054 13.6 0.1 4.7 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 KOO33831.1 - 0.02 15.3 0.0 0.15 12.5 0.0 2.2 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) FKBP_C PF00254.28 KOO33832.1 - 4.3e-24 84.7 0.0 9.1e-24 83.6 0.0 1.6 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase CS PF04969.16 KOO33832.1 - 9.6e-07 29.7 0.0 1.4e-06 29.2 0.0 1.2 1 0 0 1 1 1 1 CS domain DnaJ PF00226.31 KOO33832.1 - 0.00089 19.3 0.0 0.0014 18.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain EamA PF00892.20 KOO33833.1 - 0.00037 20.7 10.0 0.012 15.8 0.1 3.0 3 0 0 3 3 3 2 EamA-like transporter family Cys_Met_Meta_PP PF01053.20 KOO33834.1 - 1.1e-126 422.5 0.1 1.2e-126 422.3 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 KOO33834.1 - 9.1e-10 38.4 0.3 1.5e-09 37.7 0.3 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 KOO33834.1 - 5.7e-08 32.3 0.2 8.7e-08 31.7 0.2 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KOO33834.1 - 2.3e-06 26.8 0.4 4e-06 26.0 0.4 1.4 1 0 0 1 1 1 1 Aminotransferase class-V SepSecS PF05889.13 KOO33834.1 - 0.0001 21.1 0.0 0.00017 20.4 0.0 1.2 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS GDC-P PF02347.16 KOO33834.1 - 0.004 16.0 0.3 0.0066 15.3 0.3 1.4 1 0 0 1 1 1 1 Glycine cleavage system P-protein P22_CoatProtein PF11651.8 KOO33834.1 - 0.032 12.8 0.2 0.047 12.3 0.2 1.2 1 0 0 1 1 1 0 P22 coat protein - gene protein 5 Beta_elim_lyase PF01212.21 KOO33834.1 - 0.09 12.0 0.1 0.17 11.1 0.1 1.6 1 1 0 1 1 1 0 Beta-eliminating lyase Glyco_transf_41 PF13844.6 KOO33836.1 - 3e-24 85.3 0.0 3.8e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_2 PF07719.17 KOO33836.1 - 9.2e-15 53.5 17.1 0.0014 18.6 0.1 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33836.1 - 2.6e-12 46.0 1.5 0.14 12.0 0.1 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO33836.1 - 9.4e-11 41.1 1.3 0.054 13.7 0.0 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO33836.1 - 7.6e-08 31.9 4.5 6.9e-05 22.4 0.0 4.4 3 2 1 4 4 4 2 TPR repeat TPR_12 PF13424.6 KOO33836.1 - 4.4e-07 30.1 27.1 2.3e-05 24.6 1.2 4.5 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO33836.1 - 7.4e-07 29.1 3.5 1.6 9.3 0.1 5.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO33836.1 - 3.3e-06 27.5 37.0 0.034 14.9 0.8 7.4 2 1 4 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO33836.1 - 0.0013 19.3 24.8 0.0043 17.7 7.6 5.7 2 1 6 8 8 7 5 Tetratricopeptide repeat TPR_9 PF13371.6 KOO33836.1 - 0.0028 17.8 21.9 0.04 14.1 3.8 3.7 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO33836.1 - 0.0033 17.9 7.8 2.4 9.0 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat EST1_DNA_bind PF10373.9 KOO33836.1 - 0.051 13.1 0.1 0.076 12.5 0.1 1.3 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain BTAD PF03704.17 KOO33836.1 - 0.26 11.7 16.0 0.26 11.7 12.9 2.8 1 1 0 1 1 1 0 Bacterial transcriptional activator domain PCO_ADO PF07847.12 KOO33837.1 - 7.8e-43 146.3 0.0 1e-42 145.9 0.0 1.2 1 0 0 1 1 1 1 PCO_ADO Kinesin PF00225.23 KOO33838.1 - 7.6e-87 291.3 0.0 2e-86 289.9 0.0 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO33838.1 - 1.5e-15 57.5 0.2 1.1e-14 54.7 0.0 2.6 3 0 0 3 3 3 1 Microtubule binding FATC PF02260.20 KOO33838.1 - 0.27 11.1 1.4 0.83 9.5 1.4 1.9 1 0 0 1 1 1 0 FATC domain WD40_alt PF14077.6 KOO33838.1 - 0.42 10.5 11.0 8.8 6.3 0.1 5.2 5 0 0 5 5 5 0 Alternative WD40 repeat motif TPR_12 PF13424.6 KOO33841.1 - 7.6e-41 138.3 19.6 3.7e-15 56.0 0.5 3.6 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO33841.1 - 5.8e-17 61.0 5.2 4.7e-07 29.5 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO33841.1 - 2e-13 49.4 7.0 0.00033 20.5 0.1 4.6 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO33841.1 - 2e-10 40.1 0.3 0.01 15.6 0.0 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO33841.1 - 4.2e-10 39.5 2.7 6.3e-10 38.9 2.7 1.3 1 0 0 1 1 1 1 MalT-like TPR region TPR_2 PF07719.17 KOO33841.1 - 4.6e-10 38.8 1.1 0.046 13.8 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO33841.1 - 1e-08 34.7 0.3 0.14 12.4 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO33841.1 - 2e-07 31.6 11.4 2.7e-05 24.7 0.5 4.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 KOO33841.1 - 4.1e-07 30.0 10.9 0.28 11.9 0.0 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO33841.1 - 1.2e-06 29.0 6.5 0.00035 21.0 0.2 4.0 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO33841.1 - 5.8e-06 26.7 14.8 0.52 11.3 0.0 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO33841.1 - 1.3e-05 25.2 2.1 1.1 9.9 0.1 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO33841.1 - 3.4e-05 24.2 5.1 1.4 9.7 0.0 4.3 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_3 PF07720.12 KOO33841.1 - 0.00038 20.4 0.0 5.7 7.0 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_21 PF09976.9 KOO33841.1 - 5.5 6.6 5.8 12 5.6 0.0 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain DUF2452 PF10504.9 KOO33842.1 - 7.7e-15 54.7 5.3 1.7e-12 47.0 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2452) ToxN_toxin PF13958.6 KOO33842.1 - 0.015 15.5 0.3 2.8 8.1 0.2 2.4 1 1 1 2 2 2 0 Toxin ToxN, type III toxin-antitoxin system Pkinase PF00069.25 KOO33843.1 - 7.5e-28 97.6 0.0 2e-27 96.2 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain PARP PF00644.20 KOO33843.1 - 4.3e-16 59.1 0.0 9.5e-16 58.0 0.0 1.5 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase_Tyr PF07714.17 KOO33843.1 - 1.2e-15 57.6 0.0 1.9e-11 43.7 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOO33843.1 - 0.0017 17.8 0.0 0.003 16.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO33843.1 - 0.0043 16.4 0.0 0.01 15.2 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family InPase PF18823.1 KOO33843.1 - 0.02 14.6 0.9 0.041 13.6 0.1 1.9 2 0 0 2 2 2 0 Inorganic Pyrophosphatase APH PF01636.23 KOO33843.1 - 0.049 13.5 0.1 0.049 13.5 0.1 4.0 4 2 0 5 5 5 0 Phosphotransferase enzyme family YukC PF10140.9 KOO33843.1 - 0.11 11.3 0.0 0.24 10.2 0.0 1.5 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC DUF4230 PF14014.6 KOO33843.1 - 0.7 10.1 2.4 2.5 8.4 2.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) Syntaxin PF00804.25 KOO33844.1 - 4.3e-50 170.2 8.6 4.3e-50 170.2 8.6 1.4 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 KOO33844.1 - 1.9e-13 50.1 2.7 5.8e-13 48.6 2.7 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 KOO33844.1 - 4.9e-07 30.1 1.5 4.9e-07 30.1 1.5 2.3 2 1 0 2 2 2 1 Syntaxin-like protein DUF3671 PF12420.8 KOO33844.1 - 0.012 15.7 0.2 0.034 14.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function WXG100 PF06013.12 KOO33844.1 - 0.034 14.4 4.1 1.4 9.2 0.2 3.6 2 1 0 3 3 3 0 Proteins of 100 residues with WXG Baculo_PEP_C PF04513.12 KOO33844.1 - 0.1 12.6 0.2 3.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Herpes_US9 PF06072.11 KOO33844.1 - 0.1 12.5 0.6 0.22 11.4 0.6 1.5 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 DLP_helical PF18709.1 KOO33844.1 - 0.13 11.4 6.2 0.11 11.7 1.2 2.6 2 1 1 3 3 3 0 Dynamin-like helical domain OppC_N PF12911.7 KOO33844.1 - 0.16 11.9 0.9 0.31 11.0 0.9 1.3 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C ABC_tran_CTD PF16326.5 KOO33844.1 - 0.4 11.0 3.9 15 5.9 0.2 3.3 3 0 0 3 3 3 0 ABC transporter C-terminal domain Spectrin PF00435.21 KOO33844.1 - 0.57 10.7 3.6 16 6.0 0.1 3.1 3 1 0 3 3 3 0 Spectrin repeat Ima1_N PF09779.9 KOO33844.1 - 1.8 9.4 6.7 7.1 7.5 4.2 2.7 2 1 0 2 2 2 0 Ima1 N-terminal domain DUF5344 PF17279.2 KOO33844.1 - 2.2 8.9 8.0 3.5 8.3 0.9 3.5 2 2 1 3 3 3 0 Family of unknown function (DUF5344) DUF948 PF06103.11 KOO33844.1 - 2.5 8.4 6.7 1.8 8.9 0.1 3.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Synaptobrevin PF00957.21 KOO33844.1 - 2.9 7.8 8.7 1.2 9.0 3.0 2.8 2 2 0 2 2 2 0 Synaptobrevin V_ATPase_I PF01496.19 KOO33844.1 - 4.4 5.1 9.0 0.42 8.5 3.1 1.8 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF883 PF05957.13 KOO33844.1 - 7.9 7.2 10.6 9.4 6.9 1.4 3.6 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF883) PUB_1 PF18486.1 KOO33845.1 - 0.028 14.2 2.2 1 9.3 0.6 2.8 2 0 0 2 2 2 0 PNGase/UBA- or UBX-containing domain TilS PF09179.11 KOO33847.1 - 0.015 15.7 0.2 0.046 14.2 0.2 1.8 1 0 0 1 1 1 0 TilS substrate binding domain FHA PF00498.26 KOO33849.1 - 2.4e-14 53.4 0.0 3.8e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO33849.1 - 6.6e-08 32.8 0.1 1.4e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA_2 PF17913.1 KOO33849.1 - 2.6e-05 24.4 0.0 4.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain DUF433 PF04255.14 KOO33849.1 - 0.059 13.2 0.1 1 9.3 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF433) HC2 PF07382.11 KOO33850.1 - 5.9e-15 55.9 218.8 4.1e-07 30.3 49.0 4.4 2 1 3 5 5 5 4 Histone H1-like nucleoprotein HC2 Pentapeptide_4 PF13599.6 KOO33852.1 - 2.2e-07 31.0 11.7 1.3e-05 25.2 5.0 2.9 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 KOO33852.1 - 0.051 13.2 18.0 0.32 10.7 2.7 4.0 4 1 0 4 4 4 0 Pentapeptide repeats (8 copies) LRR_6 PF13516.6 KOO33853.1 - 3.5e-06 26.6 11.9 0.84 9.9 0.0 6.7 8 0 0 8 8 8 3 Leucine Rich repeat ADPrib_exo_Tox PF03496.14 KOO33853.1 - 1.2e-05 24.8 0.0 2.7e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO33853.1 - 0.0073 15.6 0.0 0.029 13.7 0.0 1.9 2 1 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase EF-hand_7 PF13499.6 KOO33854.1 - 0.005 17.3 0.0 0.012 16.1 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_10 PF14788.6 KOO33854.1 - 0.044 13.7 0.2 0.43 10.5 0.2 2.2 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.32 KOO33854.1 - 0.053 13.1 0.0 15 5.4 0.0 2.4 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 KOO33854.1 - 0.066 13.2 0.0 14 5.9 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain FXR_C1 PF16096.5 KOO33854.1 - 0.29 11.4 2.7 1 9.6 1.7 2.3 1 1 1 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 DUF2151 PF10221.9 KOO33854.1 - 1.8 7.0 6.4 2.4 6.6 6.4 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Rotamase PF00639.21 KOO33856.1 - 1.5e-20 73.9 0.1 3.6e-20 72.7 0.1 1.7 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOO33856.1 - 1.3e-14 54.8 0.0 2.3e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain PH PF00169.29 KOO33856.1 - 0.0024 18.4 0.0 0.0055 17.2 0.0 1.6 1 0 0 1 1 1 1 PH domain EccE PF11203.8 KOO33859.1 - 0.013 15.9 1.6 0.017 15.5 1.6 1.2 1 0 0 1 1 1 0 Putative type VII ESX secretion system translocon, EccE B9-C2 PF07162.11 KOO33861.1 - 2.4e-48 164.5 0.0 2.7e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein TT1725 PF18324.1 KOO33862.1 - 0.0084 16.2 0.0 0.012 15.7 0.0 1.2 1 0 0 1 1 1 1 Hypothetical protein TT1725 DEAD PF00270.29 KOO33863.1 - 1.9e-16 60.3 0.0 9.2e-16 58.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO33863.1 - 9.9e-08 32.3 0.1 4.3e-07 30.3 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 KOO33863.1 - 1.9e-05 25.3 1.2 4.1e-05 24.2 1.2 1.6 1 0 0 1 1 1 1 RecQ zinc-binding HRDC PF00570.23 KOO33863.1 - 0.002 18.0 0.2 0.0046 16.9 0.2 1.7 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 KOO33863.1 - 0.13 12.3 0.0 0.87 9.6 0.0 2.2 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Glyco_hydro_3 PF00933.21 KOO33864.1 - 3e-39 135.3 0.0 4.1e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain CBM_25 PF03423.13 KOO33864.1 - 0.06 13.6 1.6 0.33 11.2 0.2 2.5 2 0 0 2 2 2 0 Carbohydrate binding domain (family 25) DUF1538 PF07556.11 KOO33866.1 - 2.7e-93 311.1 41.1 1.2e-51 175.0 17.3 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF1538) SWIM PF04434.17 KOO33867.1 - 0.0014 18.3 0.5 0.0026 17.4 0.5 1.5 1 0 0 1 1 1 1 SWIM zinc finger Neur_chan_LBD PF02931.23 KOO33868.1 - 0.00017 21.1 0.0 0.00033 20.2 0.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain EF-hand_6 PF13405.6 KOO33868.1 - 0.0069 16.2 0.1 0.018 14.9 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO33868.1 - 0.056 13.0 0.3 0.12 11.9 0.3 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO33868.1 - 0.16 12.5 0.1 0.38 11.2 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair MTES_1575 PF18741.1 KOO33868.1 - 0.25 11.6 0.7 4.5 7.5 0.2 2.4 2 0 0 2 2 2 0 REase_MTES_1575 SPX PF03105.19 KOO33870.1 - 1.1e-18 68.4 4.2 1.8e-07 31.4 0.0 3.6 2 1 2 4 4 4 3 SPX domain VTC PF09359.10 KOO33870.1 - 2e-18 66.8 0.0 3.2e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 VTC domain UBA PF00627.31 KOO33871.1 - 6.9e-09 35.4 0.1 6.9e-09 35.4 0.1 2.0 2 0 0 2 2 2 1 UBA/TS-N domain PX PF00787.24 KOO33871.1 - 0.00015 21.8 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 PX domain UIM PF02809.20 KOO33871.1 - 0.0079 16.0 0.7 0.0079 16.0 0.7 3.6 4 0 0 4 4 4 2 Ubiquitin interaction motif UBA_4 PF14555.6 KOO33871.1 - 0.013 15.3 0.1 0.035 13.9 0.1 1.7 1 0 0 1 1 1 0 UBA-like domain YjbT PF17089.5 KOO33872.1 - 0.049 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family DnaB_bind PF10410.9 KOO33872.1 - 0.071 13.3 0.1 0.25 11.6 0.0 2.0 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase DNA_pol_A_exo1 PF01612.20 KOO33873.1 - 1.7e-19 70.2 0.0 2.3e-19 69.8 0.0 1.1 1 0 0 1 1 1 1 3'-5' exonuclease CxC6 PF18721.1 KOO33876.1 - 0.032 14.5 40.4 0.96 9.8 1.2 5.9 1 1 5 6 6 6 0 CxC6 like cysteine cluster associated with KDZ transposases ABC1 PF03109.16 KOO33877.1 - 2e-32 111.9 0.0 2.6e-24 85.7 0.0 2.7 1 1 1 2 2 2 2 ABC1 family APH PF01636.23 KOO33877.1 - 0.0012 18.9 2.7 0.082 12.8 0.0 4.0 3 2 1 4 4 4 1 Phosphotransferase enzyme family Remorin_C PF03763.13 KOO33877.1 - 0.6 10.0 3.0 1.5 8.7 0.2 2.3 2 0 0 2 2 2 0 Remorin, C-terminal region EutN_CcmL PF03319.13 KOO33879.1 - 0.68 10.6 4.0 0.99 10.0 0.0 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation protein EutN/carboxysome Lsm_C PF14894.6 KOO33880.1 - 0.17 11.7 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Lsm C-terminal VCBS PF13517.6 KOO33881.1 - 6.3e-50 167.6 63.6 1.2e-12 48.2 3.9 7.5 3 2 4 7 7 7 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO33881.1 - 2.1e-34 117.2 65.6 4.2e-05 23.6 0.5 7.8 7 0 0 7 7 7 7 FG-GAP repeat Laminin_G_3 PF13385.6 KOO33881.1 - 3.7e-09 36.9 0.0 1.3e-08 35.2 0.0 2.1 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Dockerin_1 PF00404.18 KOO33881.1 - 5.3e-05 23.3 20.6 17 5.7 0.1 7.2 7 0 0 7 7 7 1 Dockerin type I domain BBS1 PF14779.6 KOO33881.1 - 0.003 17.0 0.3 34 3.7 0.0 5.7 7 0 0 7 7 7 0 Ciliary BBSome complex subunit 1 EF-hand_1 PF00036.32 KOO33881.1 - 0.16 11.6 28.0 36 4.2 0.2 7.2 7 0 0 7 7 7 0 EF hand zf-HYPF PF07503.12 KOO33881.1 - 1.7 8.5 7.3 11 5.9 1.4 2.8 2 0 0 2 2 2 0 HypF finger EF-hand_5 PF13202.6 KOO33881.1 - 9.1 6.0 45.1 14 5.4 0.6 7.3 7 0 0 7 7 7 0 EF hand AOX PF01786.17 KOO33882.1 - 1.8e-26 93.0 0.1 2.4e-26 92.7 0.1 1.1 1 0 0 1 1 1 1 Alternative oxidase GIDA PF01134.22 KOO33883.1 - 2.1e-133 445.3 0.0 3.4e-133 444.5 0.0 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 KOO33883.1 - 9.3e-65 218.7 0.0 1.3e-64 218.3 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 KOO33883.1 - 2.1e-07 30.6 3.3 3.4e-07 30.0 3.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOO33883.1 - 4.1e-05 22.9 7.2 0.00013 21.2 3.7 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 KOO33883.1 - 6e-05 22.4 2.5 0.00012 21.4 2.5 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOO33883.1 - 0.00071 18.9 1.7 0.0015 17.9 1.7 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 KOO33883.1 - 0.0091 16.5 1.4 0.027 15.0 1.2 1.9 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOO33883.1 - 0.015 14.6 4.2 0.26 10.5 4.2 2.2 1 1 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 KOO33883.1 - 0.018 13.8 2.7 0.11 11.2 3.3 1.8 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 KOO33883.1 - 0.019 14.2 0.5 0.046 13.0 0.4 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO33883.1 - 0.052 12.8 2.2 0.1 11.8 2.2 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 KOO33883.1 - 0.077 13.2 1.9 0.26 11.5 1.9 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 KOO33883.1 - 0.77 8.5 1.9 1.2 8.0 1.9 1.2 1 0 0 1 1 1 0 Tryptophan halogenase DAO PF01266.24 KOO33883.1 - 8.6 5.8 11.8 13 5.3 6.8 2.4 1 1 0 2 2 2 0 FAD dependent oxidoreductase MA3 PF02847.17 KOO33884.1 - 1.7e-20 73.1 0.0 3.3e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 KOO33884.1 - 0.00057 19.6 0.1 0.0019 17.8 0.0 1.8 2 0 0 2 2 2 1 MIF4G domain ADH_zinc_N PF00107.26 KOO33884.1 - 0.075 13.0 0.0 0.19 11.7 0.0 1.6 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Ank_2 PF12796.7 KOO33885.1 - 1.2e-12 48.2 0.1 2e-07 31.5 0.0 2.9 2 2 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33885.1 - 4.5e-08 33.5 0.1 0.0021 18.6 0.1 3.7 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO33885.1 - 8e-07 29.2 1.4 0.24 11.9 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOO33885.1 - 0.00025 21.3 0.1 0.075 13.4 0.2 3.2 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33885.1 - 0.05 14.2 0.2 8.4 7.3 0.0 3.8 3 1 0 3 3 3 0 Ankyrin repeat ShK PF01549.24 KOO33886.1 - 9.7e-43 144.4 100.9 3.5e-08 33.8 10.0 8.2 8 0 0 8 8 8 7 ShK domain-like DnaJ PF00226.31 KOO33886.1 - 8.1e-19 67.5 0.3 1.3e-18 66.8 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain TetR_C_20 PF17925.1 KOO33887.1 - 0.08 13.3 5.4 0.38 11.1 0.6 2.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain p450 PF00067.22 KOO33888.1 - 4.6e-12 45.4 0.0 6.4e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 SelR PF01641.18 KOO33889.1 - 1.4e-13 51.0 0.0 2.5e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 SelR domain SAP PF02037.27 KOO33889.1 - 5.7e-08 32.3 0.1 1.1e-07 31.5 0.1 1.4 1 0 0 1 1 1 1 SAP domain WD40 PF00400.32 KOO33890.1 - 1.9e-43 145.6 27.6 2.4e-10 40.8 0.6 8.0 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO33890.1 - 1.4e-22 79.8 6.3 0.00031 21.0 0.1 6.0 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 KOO33890.1 - 7.3e-09 35.3 0.2 1.4e-08 34.4 0.2 1.5 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 KOO33890.1 - 8.3e-09 35.6 0.3 0.0073 16.2 0.1 3.2 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KOO33890.1 - 6.4e-05 22.4 0.0 0.089 12.1 0.0 2.7 3 1 0 3 3 3 2 WD40-like domain VID27 PF08553.10 KOO33890.1 - 0.091 11.8 0.0 4.8 6.1 0.0 2.1 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain ubiquitin PF00240.23 KOO33891.1 - 9.2e-07 28.5 0.0 1.7e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOO33891.1 - 0.049 13.5 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like CENP-B_dimeris PF09026.10 KOO33891.1 - 0.13 12.7 5.3 0.29 11.6 5.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain MAJIN PF15077.6 KOO33892.1 - 0.038 13.8 6.6 0.044 13.6 6.6 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein SPT16 PF08644.11 KOO33892.1 - 1.1 9.5 8.0 1.3 9.2 8.0 1.1 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) Exonuc_VII_L PF02601.15 KOO33892.1 - 4.7 6.7 11.4 5.2 6.5 11.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.12 KOO33892.1 - 8 4.9 8.5 8.5 4.8 8.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Peptidase_M41 PF01434.18 KOO33893.1 - 4.9e-62 209.2 0.1 8e-62 208.5 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KOO33893.1 - 1.8e-42 144.9 0.0 4e-42 143.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOO33893.1 - 7.7e-12 44.8 0.1 2.3e-11 43.3 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 KOO33893.1 - 3e-10 40.4 0.0 7.8e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 KOO33893.1 - 9.5e-05 22.4 0.0 0.00041 20.4 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO33893.1 - 0.001 19.3 0.5 0.13 12.5 0.1 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 KOO33893.1 - 0.0014 18.4 0.0 0.0053 16.5 0.0 2.0 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 KOO33893.1 - 0.0032 17.2 0.1 0.11 12.3 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein TIP49 PF06068.13 KOO33893.1 - 0.0066 15.7 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 KOO33893.1 - 0.0075 16.4 0.0 0.033 14.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOO33893.1 - 0.0091 16.4 2.3 0.057 13.8 0.2 2.9 2 1 1 3 3 3 1 AAA ATPase domain Mg_chelatase PF01078.21 KOO33893.1 - 0.053 12.9 0.1 0.14 11.6 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KOO33893.1 - 0.061 13.5 0.2 0.19 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KOO33893.1 - 0.14 12.6 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain LRR_6 PF13516.6 KOO33894.1 - 1.9e-15 55.5 4.1 0.00067 19.5 0.1 3.8 3 0 0 3 3 3 3 Leucine Rich repeat partial_CstF PF15861.5 KOO33894.1 - 0.12 12.2 0.9 6.7 6.6 0.1 2.7 2 0 0 2 2 2 0 Partial cleavage stimulation factor domain CbiG_N PF11760.8 KOO33894.1 - 0.71 9.9 8.0 28 4.8 0.4 3.8 2 1 1 3 3 3 0 Cobalamin synthesis G N-terminal Arm-DNA-bind_1 PF09003.10 KOO33894.1 - 0.74 10.0 5.0 11 6.3 0.1 3.2 3 0 0 3 3 3 0 Bacteriophage lambda integrase, Arm DNA-binding domain Proteasome PF00227.26 KOO33895.1 - 1.7e-45 154.9 0.7 2.3e-45 154.4 0.7 1.2 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 KOO33895.1 - 0.023 14.1 0.2 0.023 14.1 0.2 2.1 2 0 0 2 2 2 0 Proteasome beta subunits C terminal Trehalase PF01204.18 KOO33896.1 - 3e-08 32.9 0.2 1.3e-06 27.6 0.2 2.6 2 1 0 2 2 2 2 Trehalase Glyco_hydro_63 PF03200.16 KOO33896.1 - 0.053 12.3 0.0 0.092 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 C-terminal domain DAGAT PF03982.13 KOO33897.1 - 2.5e-41 141.5 0.1 3.5e-41 141.1 0.1 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Glyco_transf_24 PF18404.1 KOO33897.1 - 0.066 12.6 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Glucosyltransferase 24 Myb_DNA-bind_7 PF15963.5 KOO33898.1 - 0.041 13.8 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 Myb DNA-binding like NTP_transf_2 PF01909.23 KOO33900.1 - 5.6e-07 29.8 0.0 1.2e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 KOO33900.1 - 0.024 14.7 0.0 0.044 13.9 0.0 1.3 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Pribosyltran PF00156.27 KOO33901.1 - 3.5e-12 46.1 0.2 4.6e-12 45.7 0.2 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain M16C_assoc PF08367.11 KOO33902.1 - 4.1e-55 186.6 0.0 6.5e-55 186.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 KOO33902.1 - 1.7e-14 54.3 0.0 6.3e-12 45.9 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOO33902.1 - 2.9e-06 27.3 0.0 1.2e-05 25.3 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Pkinase PF00069.25 KOO33903.1 - 2.1e-14 53.5 0.0 2.6e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33903.1 - 8.1e-05 22.0 0.0 0.00011 21.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO33903.1 - 0.0051 16.8 0.8 0.78 9.6 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family EF-hand_7 PF13499.6 KOO33904.1 - 8.3e-13 48.6 1.5 3.7e-12 46.5 0.0 2.6 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO33904.1 - 1.7e-11 42.8 1.8 5.3e-05 22.5 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KOO33904.1 - 4.9e-10 38.5 0.1 2.1e-06 27.2 0.0 3.5 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO33904.1 - 0.033 14.0 2.9 2.5 8.0 0.1 3.4 3 0 0 3 3 3 0 EF-hand domain pair VCBS PF13517.6 KOO33904.1 - 0.049 14.2 0.3 3.7 8.2 0.0 2.7 3 0 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_5 PF13202.6 KOO33904.1 - 0.1 12.1 1.1 0.76 9.4 0.0 2.8 3 0 0 3 3 3 0 EF hand PHBC_N PF12551.8 KOO33905.1 - 0.13 12.1 0.1 0.35 10.7 0.1 1.7 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase N terminal Helitron_like_N PF14214.6 KOO33906.1 - 1.3e-08 35.3 0.0 2.4e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus MUG113 PF13455.6 KOO33906.1 - 0.11 13.2 0.0 0.29 11.8 0.0 1.7 1 0 0 1 1 1 0 Meiotically up-regulated gene 113 AhpC-TSA_2 PF13911.6 KOO33907.1 - 1.2e-05 25.4 0.0 3.9e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme IQ PF00612.27 KOO33908.1 - 0.00018 21.0 0.3 0.00018 21.0 0.3 2.7 3 0 0 3 3 3 1 IQ calmodulin-binding motif PX PF00787.24 KOO33908.1 - 0.00068 19.6 0.0 0.002 18.1 0.0 1.7 2 0 0 2 2 2 1 PX domain ABC_membrane PF00664.23 KOO33909.1 - 1.4e-51 175.7 0.5 1.7e-29 103.4 0.7 2.9 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOO33909.1 - 1.4e-16 61.3 0.1 5.3e-12 46.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOO33909.1 - 0.01 15.3 0.1 5 6.5 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 KOO33909.1 - 0.24 11.5 0.2 0.38 10.8 0.2 1.3 1 0 0 1 1 1 0 Dynamin family AAA_23 PF13476.6 KOO33909.1 - 0.27 11.7 0.0 0.48 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 KOO33909.1 - 0.3 10.8 0.9 25 4.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Phosphoesterase PF04185.14 KOO33910.1 - 2.9e-49 168.2 0.5 1.3e-47 162.7 0.5 2.7 1 1 0 1 1 1 1 Phosphoesterase family Pkinase PF00069.25 KOO33911.1 - 2.3e-22 79.6 0.0 4e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33911.1 - 2.8e-13 49.7 0.0 5.3e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO33911.1 - 5.3e-06 25.9 0.1 1.6e-05 24.4 0.1 1.8 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ion_trans_2 PF07885.16 KOO33912.1 - 3.9e-37 126.1 30.6 1.2e-10 41.2 2.5 4.5 4 0 0 4 4 4 4 Ion channel Ion_trans PF00520.31 KOO33912.1 - 0.0024 17.2 10.7 0.25 10.5 0.0 3.3 3 1 1 4 4 4 2 Ion transport protein TMEM65 PF10507.9 KOO33912.1 - 0.019 14.9 0.6 0.14 12.1 0.0 2.7 2 0 0 2 2 2 0 Transmembrane protein 65 IRK PF01007.20 KOO33912.1 - 0.19 11.6 4.5 0.32 10.8 0.9 2.5 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain Ank_2 PF12796.7 KOO33913.1 - 3.8e-99 325.4 32.1 8.3e-16 58.4 0.2 5.8 1 1 8 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33913.1 - 2.4e-39 133.2 8.5 1.6e-06 28.6 0.0 8.1 5 4 5 10 10 10 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO33913.1 - 1.7e-37 127.0 13.9 2.4e-08 34.1 0.1 9.1 1 1 8 10 10 10 10 Ankyrin repeats (many copies) Ank PF00023.30 KOO33913.1 - 6.7e-29 99.1 36.6 0.005 17.2 0.0 11.1 11 0 0 11 11 11 9 Ankyrin repeat Ank_3 PF13606.6 KOO33913.1 - 1.1e-21 74.5 10.7 0.68 10.7 0.0 11.0 11 0 0 11 11 11 4 Ankyrin repeat SR1P PF13790.6 KOO33913.1 - 6.5e-05 23.0 4.7 0.56 10.4 0.0 4.9 5 0 0 5 5 5 2 SR1 protein VWA_3_C PF18571.1 KOO33913.1 - 0.0026 17.6 2.2 8.7 6.3 0.0 5.0 4 0 0 4 4 4 1 von Willebrand factor type A C-terminal domain FCD PF07729.12 KOO33913.1 - 0.3 11.5 4.1 4.8 7.6 0.0 4.3 5 2 1 6 6 6 0 FCD domain Nucleotid_trans PF03407.16 KOO33916.1 - 0.00014 21.9 0.0 0.21 11.6 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-diphospho-sugar transferase PMT_2 PF13231.6 KOO33919.1 - 0.024 14.9 5.9 0.024 14.9 5.9 2.5 2 2 1 3 3 3 0 Dolichyl-phosphate-mannose-protein mannosyltransferase GSHPx PF00255.19 KOO33920.1 - 5.1e-36 122.5 0.0 7.5e-36 122.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase ShK PF01549.24 KOO33920.1 - 2.3e-08 34.4 5.6 4.8e-08 33.4 5.6 1.5 1 0 0 1 1 1 1 ShK domain-like mRNA_cap_enzyme PF01331.19 KOO33922.1 - 3.7e-34 118.3 0.0 3e-19 69.6 0.0 3.1 2 1 0 2 2 2 2 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 KOO33922.1 - 6.7e-17 62.1 0.2 1.1e-16 61.4 0.2 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain LRR_8 PF13855.6 KOO33923.1 - 1.3e-11 44.1 3.2 0.0051 16.5 0.0 4.9 4 1 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 KOO33923.1 - 2.4e-05 24.2 4.0 44 5.2 0.0 7.1 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_4 PF12799.7 KOO33923.1 - 0.00029 21.1 1.5 2.9 8.4 0.2 4.7 4 1 0 5 5 5 1 Leucine Rich repeats (2 copies) CD24 PF14984.6 KOO33923.1 - 0.071 13.3 2.2 0.37 11.1 2.2 2.3 1 0 0 1 1 1 0 CD24 protein CIA30 PF08547.12 KOO33924.1 - 5e-32 111.1 0.0 5.7e-32 110.9 0.0 1.0 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Peptidase_C1 PF00112.23 KOO33925.1 - 2.4e-43 148.7 2.8 3.8e-43 148.1 2.8 1.2 1 0 0 1 1 1 1 Papain family cysteine protease TraB PF01963.17 KOO33926.1 - 1.5e-05 25.0 0.0 2.8e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 TraB family FAA_hydro_N_2 PF18288.1 KOO33926.1 - 0.073 13.5 0.5 1.1 9.7 0.0 2.6 2 1 1 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 Fasciclin PF02469.22 KOO33927.1 - 1.6e-35 122.1 0.0 2.6e-35 121.4 0.0 1.4 1 0 0 1 1 1 1 Fasciclin domain Ribosomal_L38e PF01781.18 KOO33927.1 - 0.13 12.3 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 Ribosomal L38e protein family PseudoU_synth_2 PF00849.22 KOO33928.1 - 8.9e-26 90.9 0.0 1.3e-25 90.4 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Peptidase_M41 PF01434.18 KOO33929.1 - 1.8e-56 191.0 0.0 3e-56 190.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KOO33929.1 - 5.4e-42 143.3 0.0 1.7e-41 141.8 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) EF-hand_6 PF13405.6 KOO33929.1 - 5.1e-15 54.1 10.0 0.00016 21.4 0.1 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO33929.1 - 1.8e-14 52.1 7.9 6e-05 22.3 0.3 5.1 4 0 0 4 4 4 3 EF hand Exo_endo_phos PF03372.23 KOO33929.1 - 6.6e-13 48.7 0.0 1.4e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family EF-hand_7 PF13499.6 KOO33929.1 - 1.1e-11 45.0 3.1 1.7e-08 34.8 0.6 3.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO33929.1 - 1e-08 34.3 16.0 0.00047 19.5 0.7 4.6 5 0 0 5 5 4 3 EF hand AAA_lid_3 PF17862.1 KOO33929.1 - 1.5e-08 34.3 0.1 4.2e-08 32.9 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain EF-hand_8 PF13833.6 KOO33929.1 - 1.3e-07 31.3 1.5 0.0053 16.6 0.1 3.8 3 0 0 3 3 3 2 EF-hand domain pair Caleosin PF05042.13 KOO33929.1 - 0.0016 18.4 0.2 0.67 9.9 0.1 3.2 1 1 0 2 2 2 1 Caleosin related protein RuvB_N PF05496.12 KOO33929.1 - 0.0042 16.9 0.1 0.024 14.4 0.0 2.3 4 0 0 4 4 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KOO33929.1 - 0.0042 17.2 0.1 0.065 13.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 KOO33929.1 - 0.0087 15.3 0.1 0.016 14.5 0.1 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_17 PF13207.6 KOO33929.1 - 0.036 14.5 0.1 0.11 13.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 KOO33929.1 - 0.042 14.0 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) SPARC_Ca_bdg PF10591.9 KOO33929.1 - 0.049 14.0 0.3 0.29 11.5 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region AAA_5 PF07728.14 KOO33929.1 - 0.073 13.1 0.2 0.6 10.1 0.2 2.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 KOO33929.1 - 0.099 12.9 0.0 0.35 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain 4HB_MCP_1 PF12729.7 KOO33929.1 - 0.14 11.7 0.1 0.33 10.5 0.1 1.5 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Mg_chelatase PF01078.21 KOO33929.1 - 0.15 11.4 0.1 0.32 10.4 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 KOO33929.1 - 0.17 12.2 0.1 1.3 9.3 0.0 2.5 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.6 KOO33929.1 - 0.25 11.7 0.0 0.25 11.7 0.0 3.6 4 1 0 4 4 3 0 AAA ATPase domain DnaJ PF00226.31 KOO33930.1 - 1.3e-07 31.6 0.1 3.2e-07 30.4 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain DUF4407 PF14362.6 KOO33930.1 - 0.095 12.0 4.4 0.12 11.7 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Keratin_2_head PF16208.5 KOO33930.1 - 0.11 12.6 12.1 0.15 12.2 12.1 1.2 1 0 0 1 1 1 0 Keratin type II head Methyltransf_28 PF02636.17 KOO33930.1 - 0.12 11.9 0.4 0.18 11.4 0.4 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Phage_holin_7_1 PF16081.5 KOO33930.1 - 0.19 11.9 0.3 0.27 11.4 0.3 1.2 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family DUF4140 PF13600.6 KOO33930.1 - 0.23 11.9 5.3 46 4.5 6.8 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF2967 PF11179.8 KOO33930.1 - 1.6 6.7 4.2 1.8 6.6 4.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) TipAS PF07739.13 KOO33930.1 - 3.6 8.2 10.1 5.1 7.7 5.4 2.2 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain 14-3-3 PF00244.20 KOO33931.1 - 8.8e-95 316.4 1.7 9.9e-95 316.2 1.7 1.0 1 0 0 1 1 1 1 14-3-3 protein NIBRIN_BRCT_II PF16508.5 KOO33931.1 - 0.21 12.0 1.0 4.1 7.8 0.1 2.7 1 1 2 3 3 3 0 Second BRCT domain on Nijmegen syndrome breakage protein TPR_8 PF13181.6 KOO33931.1 - 2.2 8.7 5.8 2.5 8.5 0.6 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Branch PF02485.21 KOO33932.1 - 1e-10 41.6 0.0 1.4e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme RRM_1 PF00076.22 KOO33933.1 - 2.4e-85 280.3 1.5 1.9e-20 72.4 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KOO33933.1 - 2e-29 101.6 0.2 6.7e-28 96.7 0.2 2.9 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 KOO33933.1 - 7.9e-13 48.1 0.1 0.024 14.3 0.0 4.2 1 1 3 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO33933.1 - 2.1e-06 27.5 0.0 0.1 12.5 0.0 2.9 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 KOO33933.1 - 0.00012 22.1 0.2 4.1 7.6 0.0 4.9 4 2 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KOO33933.1 - 0.00013 21.8 0.2 3.6 7.7 0.0 4.1 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif SET_assoc PF11767.8 KOO33933.1 - 0.0019 17.8 0.0 2.9 7.6 0.0 3.3 3 0 0 3 3 3 1 Histone lysine methyltransferase SET associated RRM_3 PF08777.11 KOO33933.1 - 0.0033 17.4 1.1 42 4.3 0.1 4.0 4 0 0 4 4 4 0 RNA binding motif OB_RNB PF08206.11 KOO33933.1 - 0.13 12.0 5.5 12 5.6 0.0 3.5 3 0 0 3 3 3 0 Ribonuclease B OB domain Arm PF00514.23 KOO33935.1 - 8e-177 568.8 164.3 1.2e-06 28.3 0.1 49.9 49 2 1 50 50 50 38 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO33935.1 - 2.4e-18 66.0 8.9 0.015 15.3 0.0 15.0 14 3 4 20 20 20 4 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO33935.1 - 1e-13 51.4 4.1 11 5.4 0.0 12.8 10 5 3 15 15 15 2 Armadillo-like DUF5578 PF17741.1 KOO33935.1 - 5.4e-13 49.0 22.6 0.013 15.0 0.3 10.5 7 2 3 11 11 11 4 Family of unknown function (DUF5578) V-ATPase_H_N PF03224.14 KOO33935.1 - 3.5e-10 39.7 0.8 3.4 6.9 0.0 7.8 6 3 0 6 6 6 3 V-ATPase subunit H Adaptin_N PF01602.20 KOO33935.1 - 8.2e-08 31.2 9.6 0.37 9.3 0.0 8.8 7 4 1 9 9 9 2 Adaptin N terminal region Cnd1 PF12717.7 KOO33935.1 - 2.1e-06 27.9 0.9 3.6 7.6 0.1 6.7 6 0 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 RICTOR_N PF14664.6 KOO33935.1 - 0.0042 16.1 0.4 20 4.0 0.0 6.5 7 2 1 8 8 8 0 Rapamycin-insensitive companion of mTOR, N-term HEAT_EZ PF13513.6 KOO33935.1 - 0.0091 16.5 1.8 0.0091 16.5 1.8 25.1 22 4 8 30 30 30 6 HEAT-like repeat DUF3432 PF11914.8 KOO33935.1 - 0.042 14.1 12.1 0.14 12.4 12.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) zf-CCCH_4 PF18044.1 KOO33936.1 - 0.24 11.3 6.2 1.2 9.0 6.2 2.1 1 1 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOO33936.1 - 0.28 11.3 4.9 1.5 9.0 0.6 2.5 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH PF00642.24 KOO33936.1 - 2.7 8.0 4.7 12 5.9 4.7 2.0 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pkinase PF00069.25 KOO33938.1 - 0.0057 16.1 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO33939.1 - 3.1e-33 115.2 0.0 3.7e-33 114.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO33939.1 - 7.7e-32 110.7 0.0 9.1e-32 110.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 KOO33939.1 - 7e-05 22.3 0.0 8.8e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO33939.1 - 0.00017 21.6 1.0 0.00066 19.7 0.6 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO33939.1 - 0.0023 16.8 0.0 0.004 16.0 0.0 1.5 1 1 0 1 1 1 1 Fungal protein kinase UCH PF00443.29 KOO33941.1 - 6.8e-32 111.0 0.0 8.1e-32 110.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO33941.1 - 5.2e-21 75.6 0.0 9.4e-21 74.7 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C2H2 PF00096.26 KOO33941.1 - 7.6 7.2 8.0 2.6 8.7 3.2 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type TIR_2 PF13676.6 KOO33943.1 - 0.0058 17.2 0.0 1 10.0 0.0 2.5 2 0 0 2 2 2 2 TIR domain SbcD_C PF12320.8 KOO33943.1 - 0.0072 16.6 0.9 2.2 8.6 0.0 2.5 2 0 0 2 2 2 2 Type 5 capsule protein repressor C-terminal domain PRIMA1 PF16101.5 KOO33943.1 - 5.2 7.1 6.6 17 5.4 6.6 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 C2 PF00168.30 KOO33946.1 - 6.8e-17 61.6 0.0 1.2e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain Ion_trans PF00520.31 KOO33946.1 - 8.7e-14 51.3 4.0 1.3e-13 50.7 4.0 1.3 1 0 0 1 1 1 1 Ion transport protein Exo_endo_phos PF03372.23 KOO33948.1 - 0.00057 19.5 0.6 0.0011 18.5 0.6 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family UPF0227 PF05728.12 KOO33948.1 - 0.0017 18.3 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_1 PF00561.20 KOO33948.1 - 0.03 14.0 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOO33948.1 - 0.039 13.2 0.1 0.061 12.6 0.1 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Esterase PF00756.20 KOO33948.1 - 0.077 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative esterase AlaDh_PNT_C PF01262.21 KOO33948.1 - 0.19 11.0 0.9 0.4 10.0 0.9 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DEC-1_N PF04625.13 KOO33948.1 - 0.43 9.5 4.3 0.74 8.8 4.3 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Abhydrolase_6 PF12697.7 KOO33948.1 - 1.5 9.4 18.5 0.14 12.7 10.8 2.7 1 1 2 3 3 3 0 Alpha/beta hydrolase family Glyco_hydro_127 PF07944.12 KOO33949.1 - 1.6e-61 208.4 0.0 2.1e-48 165.1 0.0 2.9 2 1 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 PAN_1 PF00024.26 KOO33949.1 - 0.0039 17.1 0.2 0.008 16.1 0.2 1.5 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 KOO33949.1 - 0.021 14.7 0.5 0.021 14.7 0.5 2.8 4 0 0 4 4 4 0 PAN domain FtsJ PF01728.19 KOO33950.1 - 4.2e-20 72.6 0.0 1.3e-19 71.0 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.23 KOO33950.1 - 4.1e-11 42.6 1.0 1e-10 41.3 1.0 1.7 1 0 0 1 1 1 1 G-patch domain PsbN PF02468.15 KOO33952.1 - 0.095 12.6 0.2 0.55 10.1 0.0 2.5 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) Ank_2 PF12796.7 KOO33953.1 - 1.4e-85 281.9 42.0 1.7e-18 66.9 0.5 6.2 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO33953.1 - 1.6e-45 152.9 11.7 1.5e-07 31.8 0.0 8.2 5 1 1 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO33953.1 - 4.1e-44 148.0 30.3 3.4e-06 27.2 0.5 11.2 1 1 10 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO33953.1 - 1.7e-34 113.9 24.5 0.0054 17.1 0.1 12.1 12 0 0 12 12 12 11 Ankyrin repeat Ank PF00023.30 KOO33953.1 - 6.7e-31 105.4 57.6 0.0011 19.3 0.2 12.4 11 1 2 13 13 13 11 Ankyrin repeat SR1P PF13790.6 KOO33953.1 - 1.3e-07 31.6 2.5 2 8.6 0.0 7.2 8 0 0 8 8 8 2 SR1 protein GREB1 PF15782.5 KOO33953.1 - 2.6 5.0 3.7 3.2 4.7 3.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer JmjC PF02373.22 KOO33954.1 - 2e-11 44.3 0.0 4.7e-11 43.1 0.0 1.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 KOO33954.1 - 2.4e-11 43.9 0.0 3.1e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO33954.1 - 0.012 15.1 0.0 0.019 14.4 0.0 1.4 2 0 0 2 2 2 0 Cupin superfamily protein Cupin_2 PF07883.11 KOO33954.1 - 0.031 14.0 0.0 0.13 12.0 0.0 1.9 2 0 0 2 2 2 0 Cupin domain Cupin_1 PF00190.22 KOO33954.1 - 0.081 12.5 0.0 0.16 11.6 0.0 1.5 2 0 0 2 2 2 0 Cupin RRM_1 PF00076.22 KOO33955.1 - 2.5e-15 56.0 0.0 6.5e-14 51.5 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nop14 PF04147.12 KOO33955.1 - 0.0059 14.9 1.9 0.0082 14.4 1.9 1.1 1 0 0 1 1 1 1 Nop14-like family RAB3GAP2_C PF14656.6 KOO33955.1 - 0.08 11.2 0.2 0.11 10.7 0.2 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus RRM_7 PF16367.5 KOO33955.1 - 0.18 12.0 0.0 0.51 10.5 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif SWIRM-assoc_2 PF16496.5 KOO33955.1 - 1.5 7.6 6.3 2.6 6.8 6.3 1.3 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal TLD PF07534.16 KOO33956.1 - 4.5e-17 62.6 0.0 1.1e-16 61.3 0.0 1.6 1 1 0 1 1 1 1 TLD Nucleotid_trans PF03407.16 KOO33957.1 - 7.7e-31 107.7 0.0 1.1e-30 107.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Ank_4 PF13637.6 KOO33958.1 - 4.1e-17 62.3 0.6 7.7e-11 42.3 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO33958.1 - 1.4e-14 53.9 1.5 1.4e-10 41.2 0.3 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO33958.1 - 3e-14 53.4 0.0 2.9e-13 50.2 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO33958.1 - 2.8e-13 49.6 0.0 6.1e-08 32.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO33958.1 - 1.1e-07 31.5 0.0 4.9e-05 23.4 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat JmjC PF02373.22 KOO33961.1 - 5e-35 120.4 0.6 8.1e-35 119.7 0.6 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 KOO33961.1 - 4.7e-12 45.7 1.5 8.6e-12 44.8 1.5 1.5 1 0 0 1 1 1 1 jmjN domain MBD PF01429.19 KOO33961.1 - 0.0025 17.5 0.0 0.0051 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyl-CpG binding domain Clr2_transil PF16761.5 KOO33961.1 - 0.1 13.5 0.1 0.29 12.0 0.1 1.8 1 0 0 1 1 1 0 Transcription-silencing protein, cryptic loci regulator Clr2 SOGA PF11365.8 KOO33962.1 - 1.2 10.3 0.1 1.2 10.3 0.1 3.8 4 1 0 4 4 4 0 Protein SOGA TRAF_BIRC3_bd PF16673.5 KOO33962.1 - 3.4 7.5 7.8 1.6 8.6 0.5 3.3 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain PMSR PF01625.21 KOO33964.1 - 2.1e-53 180.6 0.2 2.7e-53 180.3 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Vsr PF03852.15 KOO33964.1 - 0.014 15.3 0.0 0.61 10.0 0.1 2.4 2 0 0 2 2 2 0 DNA mismatch endonuclease Vsr Mg_chelatase PF01078.21 KOO33966.1 - 1.5e-14 53.9 0.4 3.2e-09 36.5 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI VWA_2 PF13519.6 KOO33966.1 - 1.3e-13 51.5 0.1 9.7e-13 48.7 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain AAA_lid_2 PF17863.1 KOO33966.1 - 1.7e-10 40.6 0.0 1.7e-10 40.6 0.0 2.6 2 0 0 2 2 1 1 AAA lid domain VWA PF00092.28 KOO33966.1 - 8.8e-08 32.6 0.0 2.4e-07 31.2 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain MCM PF00493.23 KOO33966.1 - 1.1e-07 31.2 0.0 9.3e-07 28.2 0.0 2.2 2 0 0 2 2 2 1 MCM P-loop domain Sigma54_activat PF00158.26 KOO33966.1 - 1e-05 25.3 0.0 0.0043 16.8 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.14 KOO33966.1 - 0.00012 22.1 0.0 0.0047 16.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO33966.1 - 0.0061 17.0 0.1 0.023 15.1 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain PAXIP1_C PF15364.6 KOO33966.1 - 0.088 13.1 7.1 0.2 12.0 7.1 1.5 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein VIR_N PF15912.5 KOO33966.1 - 0.12 11.9 7.3 0.21 11.1 7.3 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal DUF3834 PF12916.7 KOO33966.1 - 0.12 11.6 0.6 0.46 9.7 0.1 2.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3834) CAP_N PF01213.19 KOO33966.1 - 0.21 11.0 7.7 0.43 10.0 7.7 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CCDC53 PF10152.9 KOO33966.1 - 2.3 8.6 10.2 4.9 7.6 10.2 1.8 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex SPRY PF00622.28 KOO33967.1 - 9.7e-26 90.3 0.1 1.5e-12 47.6 0.0 3.6 3 0 0 3 3 3 3 SPRY domain PKD_channel PF08016.12 KOO33967.1 - 1.7e-24 86.3 3.9 4.7e-24 84.8 3.9 1.6 1 1 0 1 1 1 1 Polycystin cation channel DUF3638 PF12340.8 KOO33967.1 - 9.9e-15 54.5 0.0 1.1e-13 51.0 0.0 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO33967.1 - 6.5e-14 51.0 0.4 1.6e-13 49.7 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) LRR_6 PF13516.6 KOO33967.1 - 4e-13 48.3 14.2 0.0026 17.7 0.5 7.0 6 0 0 6 6 6 3 Leucine Rich repeat ATP-gua_Ptrans PF00217.19 KOO33967.1 - 3.4e-10 39.8 0.0 7.7e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain Ank_2 PF12796.7 KOO33967.1 - 8.3e-09 35.9 0.1 1.1e-07 32.3 0.1 3.1 2 1 0 2 2 1 1 Ankyrin repeats (3 copies) Ion_trans PF00520.31 KOO33967.1 - 5e-07 29.2 13.1 9e-07 28.4 13.1 1.3 1 0 0 1 1 1 1 Ion transport protein Ank_4 PF13637.6 KOO33967.1 - 8.9e-07 29.3 0.6 6.9e-06 26.5 0.0 3.0 3 1 0 3 3 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO33967.1 - 4.2e-06 26.9 0.7 0.0062 16.8 0.0 3.2 3 0 0 3 3 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO33967.1 - 0.00021 21.6 0.1 0.091 13.3 0.0 3.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 KOO33967.1 - 0.00043 20.5 0.2 0.54 11.0 0.0 3.7 2 0 0 2 2 2 1 Ankyrin repeat CUB PF00431.20 KOO33967.1 - 0.042 14.2 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 CUB domain LRR_4 PF12799.7 KOO33967.1 - 0.23 11.9 9.4 0.088 13.3 0.4 3.8 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KOO33969.1 - 6.3e-89 294.5 11.6 3.2e-37 127.3 3.2 3.0 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO33969.1 - 7.7e-21 73.6 0.0 0.0021 17.8 0.0 6.3 1 1 7 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 KOO33969.1 - 0.0015 18.9 0.4 33 5.1 0.0 5.7 5 2 2 7 7 7 0 Leucine Rich repeats (2 copies) AIMP2_LysRS_bd PF16780.5 KOO33969.1 - 0.0057 16.4 2.9 18 5.1 0.0 5.3 7 1 0 7 7 7 1 AIMP2 lysyl-tRNA synthetase binding domain AgrD PF05931.11 KOO33969.1 - 0.088 12.9 1.3 75 3.5 0.0 4.7 3 2 3 6 6 6 0 Staphylococcal AgrD protein Consortin_C PF15281.6 KOO33969.1 - 6.5 6.8 12.6 8.8 6.4 0.3 3.8 3 1 1 4 4 4 0 Consortin C-terminus NDUF_B7 PF05676.13 KOO33970.1 - 1.4e-27 95.1 1.5 1.9e-27 94.7 1.5 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 KOO33970.1 - 0.018 15.0 0.1 0.028 14.4 0.1 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like 60KD_IMP PF02096.20 KOO33971.1 - 8.7e-24 84.3 0.0 1.2e-23 83.8 0.0 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein TPR_12 PF13424.6 KOO33971.1 - 3.2e-05 24.1 1.9 8.9e-05 22.7 1.9 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat NRBF2_MIT PF17169.4 KOO33971.1 - 0.34 11.2 2.3 0.81 9.9 2.3 1.6 1 0 0 1 1 1 0 MIT domain of nuclear receptor-binding factor 2 TPR_10 PF13374.6 KOO33971.1 - 0.8 9.7 5.4 0.43 10.5 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_6 PF13516.6 KOO33973.1 - 1.1e-17 62.4 18.4 6.9e-05 22.6 0.2 8.8 9 0 0 9 9 9 6 Leucine Rich repeat LRR_1 PF00560.33 KOO33973.1 - 1.5e-05 24.9 0.5 19 6.3 0.0 6.8 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO33973.1 - 0.0001 22.0 3.3 21 5.0 0.1 6.4 7 1 1 8 8 8 2 Leucine rich repeat LRR_4 PF12799.7 KOO33973.1 - 0.00057 20.2 9.2 5.6 7.5 0.2 5.3 4 2 1 5 5 5 2 Leucine Rich repeats (2 copies) YusW PF14039.6 KOO33973.1 - 0.16 12.5 0.1 30 5.2 0.0 2.8 3 0 0 3 3 3 0 YusW-like protein UBA_e1_thiolCys PF10585.9 KOO33974.1 - 1.2e-65 222.0 0.0 1.7e-65 221.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site ThiF PF00899.21 KOO33974.1 - 4.1e-61 206.5 0.0 8.4e-40 136.7 0.0 3.2 2 1 1 3 3 3 2 ThiF family E1_4HB PF16191.5 KOO33974.1 - 2.1e-14 53.4 0.0 6.6e-14 51.9 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle CRISPR_Cse1 PF09481.10 KOO33974.1 - 0.044 12.9 0.6 0.74 8.8 0.1 2.1 2 0 0 2 2 2 0 CRISPR-associated protein Cse1 (CRISPR_cse1) T3SS_LEE_assoc PF13327.6 KOO33975.1 - 0.01 15.9 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 1 Type III secretion system subunit ResIII PF04851.15 KOO33976.1 - 1.5e-05 25.1 0.0 0.00091 19.3 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ADPrib_exo_Tox PF03496.14 KOO33976.1 - 2.6e-05 23.7 0.0 0.01 15.2 0.0 2.5 2 1 0 2 2 2 2 ADP-ribosyltransferase exoenzyme DEAD PF00270.29 KOO33976.1 - 4.9e-05 23.2 0.0 0.00017 21.4 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_12 PF13087.6 KOO33976.1 - 0.026 14.2 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.6 KOO33976.1 - 0.049 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_25 PF13481.6 KOO33976.1 - 0.056 13.0 0.0 0.29 10.7 0.0 2.2 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO33976.1 - 0.066 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TauE PF01925.19 KOO33976.1 - 1.1 8.8 2.6 5.8 6.5 0.0 2.5 3 0 0 3 3 3 0 Sulfite exporter TauE/SafE Beta_helix PF13229.6 KOO33978.1 - 1.1e-22 80.6 9.1 4.8e-13 49.2 2.8 2.2 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.13 KOO33978.1 - 1.2e-15 57.4 1.1 2.8e-09 36.6 0.2 2.1 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.11 KOO33978.1 - 0.0045 16.4 4.9 0.097 12.0 5.0 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1565) Methyltransf_31 PF13847.6 KOO33979.1 - 1.4e-11 44.4 0.0 1.8e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO33979.1 - 2.1e-10 41.2 0.0 4.5e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO33979.1 - 1.1e-08 35.1 0.0 1.5e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO33979.1 - 2.5e-08 34.6 0.0 5e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO33979.1 - 1.1e-07 32.4 0.0 3.5e-07 30.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO33979.1 - 0.0043 16.6 0.0 0.0072 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain AdoMet_MTase PF07757.13 KOO33979.1 - 0.046 14.1 0.0 0.093 13.1 0.0 1.6 1 1 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase WD40 PF00400.32 KOO33980.1 - 5.7e-14 52.3 9.0 7.1e-07 29.8 0.3 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat ArfGap PF01412.18 KOO33981.1 - 1.1e-32 112.5 0.0 2.5e-32 111.4 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 KOO33981.1 - 4e-20 72.3 0.5 1.7e-09 38.1 0.0 3.0 2 1 0 2 2 2 2 PH domain Ank_2 PF12796.7 KOO33981.1 - 4.6e-09 36.8 2.2 1.6e-07 31.8 0.9 3.1 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) PH_8 PF15409.6 KOO33981.1 - 4.3e-08 33.3 0.1 1.1e-06 28.8 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain Ank_4 PF13637.6 KOO33981.1 - 3.2e-07 30.7 0.8 0.081 13.5 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) BAR_3 PF16746.5 KOO33981.1 - 2.4e-05 24.2 0.7 0.00038 20.2 0.7 2.4 1 1 0 1 1 1 1 BAR domain of APPL family Ank_3 PF13606.6 KOO33981.1 - 8.5e-05 22.7 2.9 2.7 8.9 0.0 4.1 4 0 0 4 4 3 1 Ankyrin repeat PH_11 PF15413.6 KOO33981.1 - 0.0001 22.7 5.1 0.003 17.9 1.1 3.5 2 2 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 KOO33981.1 - 0.00016 21.8 0.0 0.0091 16.1 0.0 2.4 2 0 0 2 2 2 1 PH domain Ank PF00023.30 KOO33981.1 - 0.0035 17.7 5.5 0.25 11.9 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat PH_13 PF16652.5 KOO33981.1 - 0.0051 16.6 0.5 4.2 7.2 0.0 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain Ank_5 PF13857.6 KOO33981.1 - 0.007 16.7 3.4 1.2 9.6 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) PH_2 PF08458.10 KOO33981.1 - 0.046 14.1 0.1 3.2 8.1 0.0 2.4 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_17 PF18012.1 KOO33981.1 - 0.11 12.3 0.1 13 5.6 0.0 2.7 2 0 0 2 2 2 0 PH domain PH_9 PF15410.6 KOO33981.1 - 0.13 12.6 0.0 0.41 11.0 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain HIP1_clath_bdg PF16515.5 KOO33981.1 - 0.7 10.5 5.7 0.65 10.6 0.2 3.3 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 BCL_N PF04714.13 KOO33981.1 - 1.1 9.3 4.3 7.9 6.6 0.3 2.9 3 0 0 3 3 2 0 BCL7, N-terminal conserver region Dus PF01207.17 KOO33982.1 - 0.00023 20.4 0.0 0.00038 19.7 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) LON_substr_bdg PF02190.16 KOO33982.1 - 0.0011 18.9 0.0 0.1 12.5 0.0 2.4 2 0 0 2 2 2 2 ATP-dependent protease La (LON) substrate-binding domain GcrA PF07750.11 KOO33984.1 - 0.18 12.2 3.6 0.21 12.0 3.6 1.1 1 0 0 1 1 1 0 GcrA cell cycle regulator FKBP_C PF00254.28 KOO33985.1 - 1e-21 77.0 0.0 1.5e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Tmemb_185A PF10269.9 KOO33988.1 - 3e-07 30.4 1.1 5.3e-07 29.6 1.1 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein ResIII PF04851.15 KOO33988.1 - 0.00025 21.1 0.0 0.0016 18.5 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO33988.1 - 0.00067 19.5 0.0 0.0017 18.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD_C_2 PF13538.6 KOO33988.1 - 0.0021 17.8 0.2 0.0089 15.8 0.1 2.2 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 KOO33988.1 - 0.017 15.4 0.0 0.098 12.9 0.0 2.3 3 0 0 3 3 3 0 AAA domain DUF2075 PF09848.9 KOO33988.1 - 0.087 12.0 0.0 0.19 11.0 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RAP1 PF07218.11 KOO33988.1 - 1.7 6.8 4.7 3.1 6.0 4.7 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Tudor-knot PF11717.8 KOO33990.1 - 1.3e-22 79.4 8.4 0.00033 20.5 0.1 5.6 6 0 0 6 6 6 4 RNA binding activity-knot of a chromodomain MBT PF02820.18 KOO33990.1 - 3.5e-11 43.3 0.1 0.0067 16.8 0.0 4.5 4 0 0 4 4 4 3 mbt repeat TTD PF12148.8 KOO33990.1 - 2.3e-07 30.8 0.7 2.5 7.9 0.0 4.7 5 0 0 5 5 5 3 Tandem tudor domain within UHRF1 AAA_16 PF13191.6 KOO33990.1 - 6.6e-07 29.9 0.1 6.6e-07 29.9 0.1 3.3 3 1 1 4 4 3 1 AAA ATPase domain Agenet PF05641.12 KOO33990.1 - 1.1e-06 29.0 14.9 0.47 10.9 0.6 5.4 5 0 0 5 5 5 3 Agenet domain Cdc6_C PF09079.11 KOO33990.1 - 2e-06 27.7 0.0 5.1e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain SAWADEE PF16719.5 KOO33990.1 - 5.3e-06 26.5 1.3 1.9 8.5 0.0 4.8 6 0 0 6 6 6 2 SAWADEE domain AAA_22 PF13401.6 KOO33990.1 - 1.4e-05 25.4 0.0 5.4e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain PHD PF00628.29 KOO33990.1 - 0.0011 18.9 0.4 0.0026 17.6 0.4 1.7 1 0 0 1 1 1 1 PHD-finger AAA_lid_10 PF17872.1 KOO33990.1 - 0.0012 18.9 0.5 0.0031 17.6 0.5 1.6 1 0 0 1 1 1 1 AAA lid domain AAA PF00004.29 KOO33990.1 - 0.03 14.8 0.2 11 6.4 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Tudor_4 PF18358.1 KOO33990.1 - 0.34 10.5 16.8 2.6 7.7 0.2 5.8 5 1 1 6 6 6 0 Histone methyltransferase Tudor domain Retrotran_gag_2 PF14223.6 KOO33991.1 - 0.0068 16.1 0.2 0.0089 15.7 0.2 1.0 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Coiled PF05710.12 KOO33992.1 - 0.04 14.7 2.0 0.04 14.7 2.0 1.6 2 0 0 2 2 2 0 Coiled coil DUF2214 PF09980.9 KOO33992.1 - 0.19 11.5 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2214) Melibiase_2 PF16499.5 KOO33993.1 - 3.4e-37 128.2 0.0 4.3e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.18 KOO33993.1 - 0.066 12.2 0.0 0.09 11.7 0.0 1.1 1 0 0 1 1 1 0 Melibiase HMG_box PF00505.19 KOO33994.1 - 1.8e-05 25.1 0.1 1.8e-05 25.1 0.1 3.3 3 1 0 3 3 3 1 HMG (high mobility group) box RNA_polI_A34 PF08208.11 KOO33994.1 - 0.99 9.5 18.3 0.24 11.5 3.4 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 FKBP_C PF00254.28 KOO33995.1 - 9.1e-19 67.6 0.0 1.3e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase LRR_6 PF13516.6 KOO33996.1 - 4.3e-05 23.2 0.0 3.8 7.8 0.0 5.8 6 0 0 6 6 6 1 Leucine Rich repeat LRR_4 PF12799.7 KOO33996.1 - 0.025 15.0 0.0 45 4.7 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) EF-hand_6 PF13405.6 KOO33997.1 - 4.5e-24 82.3 11.1 0.00021 21.0 0.1 7.4 7 0 0 7 7 7 5 EF-hand domain EF-hand_7 PF13499.6 KOO33997.1 - 1.5e-22 79.8 15.7 9e-08 32.5 0.2 6.3 5 1 0 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.32 KOO33997.1 - 8.7e-21 71.9 15.0 0.0011 18.4 0.3 7.7 7 0 0 7 7 7 6 EF hand EF-hand_5 PF13202.6 KOO33997.1 - 1.2e-07 30.9 17.7 0.02 14.4 0.4 5.8 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO33997.1 - 1.7e-07 31.0 15.7 0.013 15.3 0.1 6.5 5 2 2 7 7 7 3 EF-hand domain pair Ribosomal_L6e PF01159.19 KOO33997.1 - 0.27 11.8 4.2 3.4 8.2 0.5 2.5 2 0 0 2 2 2 0 Ribosomal protein L6e EF-hand_4 PF12763.7 KOO33997.1 - 0.45 10.5 11.3 1.4 8.9 0.1 4.9 4 2 1 5 5 5 0 Cytoskeletal-regulatory complex EF hand Zip PF02535.22 KOO33999.1 - 2.1e-15 56.8 17.1 6.6e-13 48.6 12.5 2.2 1 1 0 2 2 2 2 ZIP Zinc transporter Na_Ca_ex PF01699.24 KOO34002.1 - 1.3e-28 99.8 31.4 2.5e-16 60.0 10.1 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SHR3_chaperone PF08229.11 KOO34002.1 - 0.079 11.9 0.3 0.21 10.5 0.3 1.7 1 1 0 1 1 1 0 ER membrane protein SH3 LRR_4 PF12799.7 KOO34003.1 - 5.7e-12 45.7 50.9 0.00029 21.2 1.8 10.3 6 3 7 13 13 13 8 Leucine Rich repeats (2 copies) Roc PF08477.13 KOO34003.1 - 2.2e-10 40.8 0.0 9.3e-10 38.8 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 KOO34003.1 - 4.3e-09 36.0 27.4 8.6e-07 28.6 6.3 8.3 7 2 2 9 9 9 4 Leucine rich repeat LRR_6 PF13516.6 KOO34003.1 - 4.5e-09 35.6 66.4 0.019 15.0 0.2 15.8 17 0 0 17 17 17 4 Leucine Rich repeat LRR_9 PF14580.6 KOO34003.1 - 0.003 17.1 1.9 0.011 15.2 1.9 2.0 1 0 0 1 1 1 1 Leucine-rich repeat NACHT PF05729.12 KOO34003.1 - 0.013 15.4 0.0 0.057 13.3 0.0 2.2 1 1 0 1 1 1 0 NACHT domain Ras PF00071.22 KOO34003.1 - 0.014 15.0 0.0 0.035 13.7 0.0 1.6 1 0 0 1 1 1 0 Ras family AAA_19 PF13245.6 KOO34003.1 - 0.024 15.0 0.0 0.11 12.9 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 KOO34003.1 - 0.035 14.5 0.0 0.26 11.7 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) LRR_1 PF00560.33 KOO34003.1 - 0.036 14.6 27.9 31 5.7 0.0 11.4 12 1 0 12 12 11 0 Leucine Rich Repeat G-alpha PF00503.20 KOO34003.1 - 0.087 12.0 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit zf-C2H2_aberr PF17017.5 KOO34004.1 - 0.15 12.2 0.1 0.19 11.8 0.1 1.1 1 0 0 1 1 1 0 Aberrant zinc-finger FOXP-CC PF16159.5 KOO34004.1 - 0.18 12.4 0.3 0.34 11.6 0.3 1.4 1 0 0 1 1 1 0 FOXP coiled-coil domain TMEM43 PF07787.12 KOO34005.1 - 0.14 11.5 3.5 0.2 11.0 3.5 1.2 1 0 0 1 1 1 0 Transmembrane protein 43 efThoc1 PF11957.8 KOO34007.1 - 5.9e-92 308.9 0.0 7.3e-92 308.6 0.0 1.0 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Pkinase PF00069.25 KOO34008.1 - 1.7e-33 116.1 0.0 5e-30 104.8 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34008.1 - 7.5e-20 71.3 0.0 1.8e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase PABP PF00658.18 KOO34008.1 - 4.8e-13 49.1 0.0 1.1e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain zf-RING_UBOX PF13445.6 KOO34008.1 - 0.012 15.6 0.7 0.039 14.0 0.7 2.0 1 0 0 1 1 1 0 RING-type zinc-finger Pkinase_fungal PF17667.1 KOO34008.1 - 0.012 14.4 0.0 0.028 13.2 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase zf-RING_2 PF13639.6 KOO34008.1 - 0.014 15.7 0.9 0.053 13.9 0.9 2.0 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 KOO34008.1 - 0.031 14.2 0.3 0.086 12.7 0.3 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Kinase-like PF14531.6 KOO34008.1 - 0.041 13.2 0.0 0.077 12.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like zf-RING_14 PF17978.1 KOO34008.1 - 0.11 12.9 0.2 0.23 11.9 0.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF3520 PF12034.8 KOO34008.1 - 1.8 8.7 5.4 0.3 11.2 1.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3520) zf-C3HC4_2 PF13923.6 KOO34008.1 - 4.6 7.2 5.3 4.8 7.1 1.3 2.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF3431 PF11913.8 KOO34009.1 - 9.3e-15 55.0 0.0 1.3e-13 51.2 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) Caps_synth PF05704.12 KOO34009.1 - 1.5e-10 40.9 0.3 3.2e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 KOO34009.1 - 0.0042 17.7 0.0 0.011 16.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif 14-3-3 PF00244.20 KOO34010.1 - 3.2e-83 278.6 3.1 3.6e-83 278.4 3.1 1.0 1 0 0 1 1 1 1 14-3-3 protein Anoctamin PF04547.12 KOO34011.1 - 1.8e-94 317.1 0.0 2.4e-94 316.8 0.0 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Actin PF00022.19 KOO34012.1 - 4e-29 101.4 0.0 6.9e-28 97.4 0.0 2.5 1 1 1 2 2 2 1 Actin FtsA PF14450.6 KOO34012.1 - 0.032 14.6 0.0 0.067 13.6 0.0 1.6 1 1 0 1 1 1 0 Cell division protein FtsA EF-hand_6 PF13405.6 KOO34014.1 - 1.7e-10 39.9 0.4 4.3e-06 26.2 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO34014.1 - 2e-10 39.4 0.4 4.1e-06 26.0 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34014.1 - 7.5e-10 39.1 5.7 3.7e-06 27.3 0.5 2.2 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO34014.1 - 1.4e-07 30.7 1.2 0.0002 20.7 0.3 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO34014.1 - 0.00016 21.4 2.1 0.069 13.0 1.1 2.3 1 1 1 2 2 2 2 EF-hand domain pair CedA PF10729.9 KOO34014.1 - 0.083 12.7 1.5 0.49 10.3 0.4 2.4 2 0 0 2 2 2 0 Cell division activator CedA DUF2309 PF10070.9 KOO34015.1 - 1.1e-154 516.8 0.0 1.5e-147 493.1 0.0 2.2 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2309) RdRP PF05183.12 KOO34016.1 - 1.3 7.5 6.0 6.5 5.3 0.1 2.1 1 1 1 2 2 2 0 RNA dependent RNA polymerase DUF1664 PF07889.12 KOO34016.1 - 1.5 8.8 7.8 8.1 6.5 0.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Pentapeptide_4 PF13599.6 KOO34017.1 - 1.9e-20 72.8 0.0 0.0021 18.2 0.0 8.3 5 3 1 7 7 7 6 Pentapeptide repeats (9 copies) Ntox33 PF15533.6 KOO34017.1 - 6.3e-05 23.4 9.1 7.9 7.0 0.0 10.5 8 6 5 13 13 13 1 Bacterial toxin 33 DUF2639 PF11121.8 KOO34017.1 - 0.013 15.6 0.2 57 3.9 0.0 5.8 4 1 1 5 5 5 0 Protein of unknown function (DUF2639) XK-related PF09815.9 KOO34017.1 - 0.024 13.7 7.9 0.069 12.2 8.0 1.6 1 1 0 1 1 1 0 XK-related protein SinI PF08671.10 KOO34017.1 - 0.062 13.1 0.0 0.21 11.4 0.0 1.9 1 0 0 1 1 1 0 Anti-repressor SinI MFAP1 PF06991.11 KOO34017.1 - 5.6 6.7 14.3 9.9 5.9 14.3 1.3 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing SURF6 PF04935.12 KOO34017.1 - 5.8 6.7 17.7 11 5.7 17.7 1.4 1 0 0 1 1 1 0 Surfeit locus protein 6 Ribosomal_L13e PF01294.18 KOO34017.1 - 9.3 6.1 37.7 1.4 8.8 0.1 11.5 9 3 5 14 14 14 0 Ribosomal protein L13e Sulfate_transp PF00916.20 KOO34018.1 - 4.6e-06 25.6 24.2 5.1e-06 25.5 15.6 4.0 2 2 2 4 4 4 1 Sulfate permease family STAS PF01740.21 KOO34018.1 - 6.2e-06 25.8 0.2 2.7e-05 23.8 0.2 2.0 1 1 0 1 1 1 1 STAS domain STAS_2 PF13466.6 KOO34018.1 - 0.14 12.6 2.7 0.32 11.4 0.2 2.9 3 0 0 3 3 3 0 STAS domain DUF4191 PF13829.6 KOO34018.1 - 7.3 5.9 6.6 1.9 7.7 2.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) CLN3 PF02487.17 KOO34019.1 - 1.1e-24 87.2 0.0 2e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 CLN3 protein RE_Bpu10I PF09549.10 KOO34019.1 - 0.19 11.3 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 Bpu10I restriction endonuclease LRR_6 PF13516.6 KOO34021.1 - 1.2e-25 87.3 16.4 0.015 15.3 0.1 8.5 8 0 0 8 8 8 7 Leucine Rich repeat EF-hand_7 PF13499.6 KOO34021.1 - 1.6e-21 76.5 5.1 5.1e-05 23.6 0.2 5.0 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO34021.1 - 1.6e-20 71.2 3.0 0.00034 20.3 0.0 7.6 7 0 0 7 7 7 5 EF-hand domain EF-hand_1 PF00036.32 KOO34021.1 - 2.9e-17 60.9 0.0 0.5 10.0 0.0 7.6 7 0 0 7 7 7 5 EF hand LSDAT_euk PF18139.1 KOO34021.1 - 4.9e-12 45.8 0.0 1.2e-11 44.6 0.0 1.5 1 1 0 1 1 1 1 SLOG in TRPM EF-hand_5 PF13202.6 KOO34021.1 - 3.1e-10 39.1 1.1 0.43 10.2 0.0 6.9 7 0 0 7 7 7 2 EF hand EF-hand_8 PF13833.6 KOO34021.1 - 4.5e-08 32.8 0.2 0.57 10.1 0.0 4.7 3 1 1 4 4 4 3 EF-hand domain pair LRR_4 PF12799.7 KOO34021.1 - 1.8e-07 31.3 0.0 5.7 7.5 0.0 4.7 3 1 1 5 5 5 2 Leucine Rich repeats (2 copies) LSDAT_prok PF18171.1 KOO34021.1 - 8.7e-07 28.4 0.0 3.9e-05 23.0 0.0 2.4 1 1 0 1 1 1 1 SLOG in TRPM, prokaryote Ank_2 PF12796.7 KOO34021.1 - 0.083 13.5 8.5 3.1 8.4 1.2 3.5 3 0 0 3 3 3 0 Ankyrin repeats (3 copies) LRR_8 PF13855.6 KOO34021.1 - 0.16 11.8 0.3 9.1 6.1 0.0 4.0 4 2 0 4 4 4 0 Leucine rich repeat DUF2783 PF10932.8 KOO34021.1 - 1 9.1 5.5 36 4.1 0.1 4.8 5 0 0 5 5 5 0 Protein of unknown function (DUF2783) Anoctamin PF04547.12 KOO34022.1 - 8.5e-106 354.5 5.2 1e-105 354.2 5.2 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KOO34022.1 - 7.8e-05 22.5 0.0 0.057 13.1 0.0 2.2 1 1 1 2 2 2 2 Dimerisation domain of Ca+-activated chloride-channel, anoctamin DUF1672 PF07901.11 KOO34022.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) IQ PF00612.27 KOO34023.1 - 0.0015 18.2 16.8 0.034 13.9 3.1 4.0 3 0 0 3 3 3 2 IQ calmodulin-binding motif TRAPPC-Trs85 PF12739.7 KOO34025.1 - 4.1 6.3 8.2 42 2.9 8.2 2.3 1 1 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Glyco_hydro_31 PF01055.26 KOO34026.1 - 3.4e-34 118.8 11.8 2.2e-33 116.2 11.8 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 DUF3584 PF12128.8 KOO34027.1 - 0.048 11.2 4.2 0.077 10.5 4.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) ATG16 PF08614.11 KOO34027.1 - 7.2 6.8 13.1 20 5.3 10.4 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) LRR_6 PF13516.6 KOO34028.1 - 1.9e-22 77.3 48.4 0.00025 20.9 0.2 16.8 17 0 0 17 17 17 7 Leucine Rich repeat LRR_1 PF00560.33 KOO34028.1 - 1.5e-09 37.0 11.9 10 7.1 0.0 9.5 10 0 0 10 10 10 3 Leucine Rich Repeat LRR_8 PF13855.6 KOO34028.1 - 4.5e-09 35.9 10.9 2.3 8.0 0.0 8.9 9 1 0 9 9 9 4 Leucine rich repeat LRR_4 PF12799.7 KOO34028.1 - 2.4e-06 27.8 22.5 0.48 10.9 0.4 8.4 8 1 0 8 8 8 1 Leucine Rich repeats (2 copies) FIBP PF05427.11 KOO34028.1 - 0.24 10.7 0.0 14 4.9 0.0 2.1 2 0 0 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) Phage_r1t_holin PF16945.5 KOO34028.1 - 0.64 10.3 4.2 24 5.2 0.1 3.2 2 0 0 2 2 2 0 Putative lactococcus lactis phage r1t holin EF-hand_1 PF00036.32 KOO34030.1 - 2.1e-05 23.7 0.1 3.6e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO34030.1 - 3.4e-05 23.4 0.1 6.6e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO34030.1 - 0.0016 17.9 0.1 0.003 17.0 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO34030.1 - 0.004 17.6 0.0 0.0066 16.9 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair Phage_holin_2_4 PF16082.5 KOO34030.1 - 0.11 12.3 0.4 0.11 12.3 0.4 3.0 2 1 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Arm PF00514.23 KOO34031.1 - 0.16 12.0 0.4 0.48 10.6 0.1 1.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Vma12 PF11712.8 KOO34031.1 - 0.83 9.7 12.4 0.52 10.4 1.8 3.2 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF1385 PF07136.11 KOO34031.1 - 2.2 7.5 7.3 0.18 11.0 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1385) Vma12 PF11712.8 KOO34032.1 - 9 6.4 10.2 9.9 6.2 0.8 3.4 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SGT1 PF07093.11 KOO34033.1 - 0.19 10.1 0.0 0.24 9.8 0.0 1.1 1 0 0 1 1 1 0 SGT1 protein U-box PF04564.15 KOO34034.1 - 6.1e-10 39.1 0.0 9.6e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 U-box domain DUF5631 PF18645.1 KOO34034.1 - 0.012 16.0 0.2 0.023 15.1 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5631) Gly-zipper_OmpA PF13436.6 KOO34034.1 - 0.048 13.5 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 Glycine-zipper domain zf-NOSIP PF15906.5 KOO34034.1 - 0.071 13.2 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein DUF5446 PF17522.2 KOO34034.1 - 0.69 10.1 3.2 1.4 9.1 3.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5446) HalX PF08663.10 KOO34034.1 - 3.3 8.1 9.9 1.7 9.0 1.2 2.4 1 1 1 2 2 2 0 HalX domain Arm PF00514.23 KOO34035.1 - 3.6e-38 128.4 28.1 7.7e-07 29.0 0.5 6.3 6 0 0 6 6 6 6 Armadillo/beta-catenin-like repeat U-box PF04564.15 KOO34035.1 - 3.3e-07 30.4 0.0 6e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain Atx10homo_assoc PF09759.9 KOO34035.1 - 5.7e-07 29.5 0.3 0.026 14.6 0.0 4.1 2 1 3 5 5 5 2 Spinocerebellar ataxia type 10 protein domain zf-Nse PF11789.8 KOO34035.1 - 0.00011 22.0 0.0 0.00026 20.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO34035.1 - 0.0057 16.8 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein DHBP_synthase PF00926.19 KOO34035.1 - 0.0079 15.7 12.7 1.1 8.8 0.1 4.3 1 1 2 4 4 4 3 3,4-dihydroxy-2-butanone 4-phosphate synthase Succ_CoA_lig PF13607.6 KOO34035.1 - 0.0083 15.9 29.5 0.19 11.5 1.1 6.0 1 1 4 6 6 6 3 Succinyl-CoA ligase like flavodoxin domain zf-RING_UBOX PF13445.6 KOO34035.1 - 0.019 15.0 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 RING-type zinc-finger LysM PF01476.20 KOO34035.1 - 0.1 12.7 5.3 17 5.6 0.1 4.3 5 0 0 5 5 5 0 LysM domain SUZ-C PF12901.7 KOO34035.1 - 0.24 11.4 7.9 57 3.8 0.0 5.9 7 0 0 7 7 7 0 SUZ-C motif TDRP PF15683.5 KOO34035.1 - 6.4 6.7 10.5 23 5.0 0.1 4.4 1 1 5 6 6 6 0 Testis development-related protein TIG PF01833.24 KOO34038.1 - 5.4e-17 61.7 0.6 2e-11 43.8 0.6 2.7 2 0 0 2 2 2 2 IPT/TIG domain TIG_plexin PF17960.1 KOO34038.1 - 0.018 15.0 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 TIG domain RdRP PF05183.12 KOO34040.1 - 4.8e-31 108.1 0.0 6.6e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Radical_SAM PF04055.21 KOO34041.1 - 4.6e-15 56.4 0.0 8.4e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily H_kinase_N PF12282.8 KOO34043.1 - 1.6 8.7 20.4 23 4.9 0.8 5.0 1 1 2 3 3 3 0 Signal transduction histidine kinase Pkinase PF00069.25 KOO34046.1 - 3.3e-05 23.4 0.0 4.4e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DnaJ PF00226.31 KOO34048.1 - 6.4e-07 29.4 1.8 1.1e-06 28.6 0.1 2.0 2 0 0 2 2 2 1 DnaJ domain SR-25 PF10500.9 KOO34049.1 - 0.0011 18.7 7.4 0.0017 18.0 7.4 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 KOO34049.1 - 0.0078 16.9 9.2 0.015 15.9 9.2 1.5 1 0 0 1 1 1 1 Immortalisation up-regulated protein DDHD PF02862.17 KOO34049.1 - 0.022 14.9 1.5 0.033 14.4 1.5 1.3 1 0 0 1 1 1 0 DDHD domain Med3 PF11593.8 KOO34049.1 - 0.051 12.8 9.3 0.077 12.2 9.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal BAF1_ABF1 PF04684.13 KOO34049.1 - 0.053 12.6 6.6 0.058 12.5 6.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CDC45 PF02724.14 KOO34049.1 - 0.18 10.0 5.4 0.22 9.8 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Raftlin PF15250.6 KOO34049.1 - 0.26 10.0 4.0 0.36 9.5 4.0 1.2 1 0 0 1 1 1 0 Raftlin RAP1 PF07218.11 KOO34049.1 - 0.37 9.0 3.9 0.46 8.7 3.9 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF913 PF06025.12 KOO34049.1 - 0.61 9.0 4.7 1.1 8.2 4.7 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 KOO34049.1 - 0.94 8.2 9.4 7.6 5.2 9.3 1.9 1 1 1 2 2 2 0 SIT4 phosphatase-associated protein DUF2052 PF09747.9 KOO34049.1 - 1.3 9.1 10.4 2.2 8.3 10.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 KOO34049.1 - 1.7 8.4 7.4 2.5 7.9 7.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 XAP5 PF04921.14 KOO34049.1 - 1.8 8.3 6.8 2.7 7.8 6.8 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator DUF2058 PF09831.9 KOO34049.1 - 1.9 8.6 11.3 0.13 12.4 5.5 1.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) Hid1 PF12722.7 KOO34049.1 - 2.1 6.4 4.4 2.3 6.3 4.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Vfa1 PF08432.10 KOO34049.1 - 2.1 8.6 9.6 3.5 7.9 9.6 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sec62 PF03839.16 KOO34049.1 - 10 5.6 5.4 15 5.0 5.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 COPI_assoc PF08507.10 KOO34052.1 - 3.6e-06 27.1 7.3 5.3e-06 26.5 7.3 1.2 1 0 0 1 1 1 1 COPI associated protein EF-hand_7 PF13499.6 KOO34052.1 - 0.092 13.2 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 KOO34052.1 - 0.14 11.8 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 EF hand UPF0016 PF01169.19 KOO34053.1 - 3.1 8.2 12.6 0.055 13.8 2.0 3.1 3 1 0 3 3 3 0 Uncharacterized protein family UPF0016 TPR_17 PF13431.6 KOO34054.1 - 0.0017 18.6 6.1 1.1 9.8 0.2 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34054.1 - 0.039 13.8 0.5 16 5.5 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO34054.1 - 0.13 12.4 2.7 6.4 7.1 0.4 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO34054.1 - 1.3 9.6 15.5 0.29 11.7 3.8 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.25 KOO34055.1 - 2.6e-31 109.0 0.0 3.7e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34055.1 - 1.5e-29 103.1 0.0 2.1e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TIR_2 PF13676.6 KOO34055.1 - 0.00017 22.2 0.0 0.0003 21.4 0.0 1.4 1 0 0 1 1 1 1 TIR domain APH PF01636.23 KOO34055.1 - 0.00019 21.4 1.6 0.0062 16.5 0.9 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO34055.1 - 0.012 14.4 0.0 0.02 13.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 KOO34055.1 - 0.063 12.6 0.4 0.098 12.0 0.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4304 PF14137.6 KOO34055.1 - 0.079 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4304) Kinase-like PF14531.6 KOO34055.1 - 0.15 11.4 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Phytochelatin PF05023.14 KOO34056.1 - 1.1e-74 250.3 0.0 1.2e-74 250.1 0.0 1.0 1 0 0 1 1 1 1 Phytochelatin synthase Arf PF00025.21 KOO34057.1 - 2.3e-70 235.6 0.3 2.6e-70 235.4 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KOO34057.1 - 3.1e-13 49.6 0.7 5.2e-07 29.1 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 KOO34057.1 - 9.9e-13 48.4 0.0 1.4e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO34057.1 - 1.9e-11 43.8 0.0 2.3e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KOO34057.1 - 2e-10 40.4 0.0 2.6e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOO34057.1 - 3.8e-09 36.3 0.0 4.6e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO34057.1 - 6.3e-06 26.3 0.0 1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOO34057.1 - 5.4e-05 22.8 0.0 0.00013 21.5 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 KOO34057.1 - 0.0077 15.7 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein cobW PF02492.19 KOO34057.1 - 0.15 11.7 0.1 0.58 9.7 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PADR1 PF08063.12 KOO34058.1 - 0.41 10.5 5.7 2.2 8.1 4.3 2.5 2 0 0 2 2 2 0 PADR1 (NUC008) domain Sec3-PIP2_bind PF15277.6 KOO34059.1 - 0.076 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH BOP1NT PF08145.12 KOO34060.1 - 3.3e-95 318.9 4.6 4.2e-95 318.6 4.6 1.1 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 KOO34060.1 - 1.3e-26 92.3 3.7 3.8e-07 30.7 0.0 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO34060.1 - 2e-07 31.2 0.0 0.11 12.9 0.0 5.2 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KOO34060.1 - 0.034 12.5 0.0 0.23 9.8 0.0 2.2 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 KOO34060.1 - 0.049 12.3 0.0 0.074 11.7 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOO34060.1 - 0.088 11.7 0.0 0.2 10.6 0.0 1.5 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Treacle PF03546.14 KOO34060.1 - 0.67 8.7 2.8 1.2 7.8 1.0 1.9 2 0 0 2 2 2 0 Treacher Collins syndrome protein Treacle Epimerase PF01370.21 KOO34061.1 - 6.2e-08 32.4 0.2 2e-06 27.5 0.2 2.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 KOO34061.1 - 0.00036 19.9 0.0 0.00064 19.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Arm PF00514.23 KOO34062.1 - 1.2e-122 396.7 150.1 4.7e-08 32.8 0.0 45.5 48 0 0 48 48 48 29 Armadillo/beta-catenin-like repeat EF-hand_7 PF13499.6 KOO34062.1 - 4.1e-20 72.0 1.8 5e-09 36.5 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO34062.1 - 1.7e-15 55.4 5.9 0.0049 16.3 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO34062.1 - 3.5e-15 54.6 2.6 0.00079 19.2 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 KOO34062.1 - 1.5e-13 50.3 1.0 6.9e-06 25.8 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain pair Atx10homo_assoc PF09759.9 KOO34062.1 - 2.7e-10 40.2 12.0 0.18 11.9 0.0 10.8 9 2 5 14 14 11 3 Spinocerebellar ataxia type 10 protein domain EF-hand_5 PF13202.6 KOO34062.1 - 1.5e-08 33.8 9.1 0.19 11.3 0.0 4.6 4 0 0 4 4 4 4 EF hand KAP PF05804.12 KOO34062.1 - 3e-08 32.3 0.0 3e-05 22.4 0.0 4.5 5 1 0 5 5 5 1 Kinesin-associated protein (KAP) DUF5578 PF17741.1 KOO34062.1 - 5.7e-05 22.7 24.0 0.022 14.2 2.7 9.7 6 3 3 11 11 11 2 Family of unknown function (DUF5578) PH PF00169.29 KOO34062.1 - 0.00012 22.6 0.0 0.00023 21.7 0.0 1.4 1 0 0 1 1 1 1 PH domain Arm_2 PF04826.13 KOO34062.1 - 0.002 17.6 9.7 28 4.0 0.1 8.5 6 4 3 9 9 9 0 Armadillo-like Adaptin_N PF01602.20 KOO34062.1 - 0.0021 16.7 8.8 1.2 7.6 0.1 5.8 7 0 0 7 7 7 2 Adaptin N terminal region Cnd1 PF12717.7 KOO34062.1 - 0.0068 16.5 7.7 17 5.4 0.2 8.3 8 2 3 11 11 11 0 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 KOO34062.1 - 0.083 13.0 0.8 9 6.4 0.3 4.5 3 0 0 3 3 3 0 V-ATPase subunit H Put_DNA-bind_N PF06971.13 KOO34062.1 - 0.16 12.0 0.2 23 5.1 0.0 2.7 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus BAF250_C PF12031.8 KOO34062.1 - 0.43 9.8 9.7 29 3.9 0.4 5.6 5 0 0 5 5 5 0 SWI/SNF-like complex subunit BAF250/Osa Cnn_1N PF07989.11 KOO34065.1 - 0.047 13.8 5.7 0.25 11.5 0.0 3.0 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Ank_2 PF12796.7 KOO34066.1 - 0.00076 20.0 0.0 0.31 11.6 0.0 3.3 4 0 0 4 4 4 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO34066.1 - 0.016 15.7 0.1 39 5.3 0.0 5.4 7 0 0 7 7 7 0 Ankyrin repeat Pico_P2B PF01552.17 KOO34066.1 - 0.075 13.2 0.0 0.29 11.3 0.0 2.0 2 0 0 2 2 2 0 Picornavirus 2B protein Ank_5 PF13857.6 KOO34066.1 - 0.14 12.5 0.0 1.2 9.6 0.0 2.5 3 0 0 3 3 3 0 Ankyrin repeats (many copies) PhageMin_Tail PF10145.9 KOO34067.1 - 0.0028 17.5 0.9 0.0028 17.5 0.9 2.3 1 1 1 2 2 2 1 Phage-related minor tail protein Filament PF00038.21 KOO34067.1 - 0.004 16.8 20.4 0.017 14.7 0.5 2.5 2 1 0 2 2 2 1 Intermediate filament protein AAA_13 PF13166.6 KOO34067.1 - 0.23 10.1 16.3 0.35 9.5 16.3 1.2 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 KOO34067.1 - 0.23 8.9 24.0 0.3 8.6 24.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 KOO34067.1 - 0.42 9.5 27.2 0.86 8.4 15.0 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.10 KOO34067.1 - 0.52 10.5 12.0 0.71 10.0 3.3 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 KOO34067.1 - 0.95 9.5 42.1 0.5 10.4 12.1 3.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.5 KOO34067.1 - 1 10.3 18.8 5.5 7.9 0.9 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF948 PF06103.11 KOO34067.1 - 1 9.7 14.5 0.62 10.4 1.2 3.1 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Golgin_A5 PF09787.9 KOO34067.1 - 2.1 7.7 17.2 7.8 5.9 0.5 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 UPF0242 PF06785.11 KOO34067.1 - 3.1 7.9 18.1 1.4 9.0 11.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 KOO34067.1 - 3.1 7.0 28.8 0.48 9.7 10.4 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) Phage_holin_7_1 PF16081.5 KOO34067.1 - 3.8 7.7 19.4 7.7 6.7 2.3 2.3 2 0 0 2 2 2 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family OmpH PF03938.14 KOO34067.1 - 3.9 7.8 35.2 0.14 12.5 7.9 2.4 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) PRTP PF01366.18 KOO34067.1 - 4.5 5.2 11.0 0.15 10.1 3.6 1.8 2 0 0 2 2 2 0 Herpesvirus processing and transport protein ApoO PF09769.9 KOO34067.1 - 4.6 7.2 6.5 0.94 9.4 1.9 2.1 2 1 0 2 2 2 0 Apolipoprotein O IFT57 PF10498.9 KOO34067.1 - 6.2 5.7 15.8 3.1 6.7 10.2 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 CENP-H PF05837.12 KOO34067.1 - 9.9 6.6 25.0 4.8 7.6 4.5 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Fimbrial_CS1 PF04449.12 KOO34070.1 - 0.13 12.3 0.7 1.1 9.4 0.5 2.0 1 1 1 2 2 2 0 CS1 type fimbrial major subunit Glutaredoxin2_C PF04399.13 KOO34071.1 - 1.3e-32 112.4 0.1 2e-21 76.2 0.0 2.1 2 0 0 2 2 2 2 Glutaredoxin 2, C terminal domain EF-hand_6 PF13405.6 KOO34072.1 - 1.1e-09 37.5 0.1 0.00045 19.9 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO34072.1 - 4.3e-09 35.3 0.1 0.0015 18.0 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34072.1 - 1.2e-06 28.9 0.0 2.8e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO34072.1 - 1.2e-05 24.5 0.0 0.14 11.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO34072.1 - 0.00039 20.2 0.1 0.0076 16.1 0.0 2.4 1 1 1 2 2 2 1 EF-hand domain pair HTH_31 PF13560.6 KOO34073.1 - 0.00053 20.3 0.1 0.0017 18.6 0.1 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain Pou PF00157.17 KOO34073.1 - 0.03 14.3 0.0 0.064 13.2 0.0 1.5 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain MFS_1 PF07690.16 KOO34074.1 - 4.2e-31 108.2 52.0 4.2e-21 75.3 28.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KOO34074.1 - 1.8e-10 40.0 22.2 1.8e-10 40.0 22.2 1.4 1 1 0 1 1 1 1 MFS/sugar transport protein MFS_3 PF05977.13 KOO34074.1 - 9.9e-05 20.9 12.3 0.00017 20.1 11.4 1.8 1 1 1 2 2 2 2 Transmembrane secretion effector DUF3485 PF11984.8 KOO34075.1 - 0.058 13.1 0.4 0.44 10.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3485) Hydrolase_4 PF12146.8 KOO34076.1 - 2.7e-07 30.1 0.0 6.6e-07 28.8 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO34076.1 - 8e-07 29.9 9.7 8e-07 29.9 9.7 3.0 2 2 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KOO34076.1 - 0.00038 20.4 0.0 0.00082 19.3 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 KOO34076.1 - 0.00056 19.6 0.0 0.011 15.4 0.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold DAGAT PF03982.13 KOO34076.1 - 0.0022 17.0 0.0 0.0031 16.5 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase UPF0227 PF05728.12 KOO34076.1 - 0.036 14.0 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Apolipoprotein PF01442.18 KOO34077.1 - 0.00066 19.6 3.8 0.00066 19.6 3.8 1.9 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain Med9 PF07544.13 KOO34077.1 - 0.21 11.7 0.9 0.49 10.5 0.9 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Ceramidase PF05875.12 KOO34078.1 - 5.8e-33 114.4 9.2 7.7e-33 114.0 9.2 1.1 1 0 0 1 1 1 1 Ceramidase LURAP PF14854.6 KOO34079.1 - 0.1 12.6 4.6 2.6 8.0 0.1 2.8 2 2 1 3 3 3 0 Leucine rich adaptor protein ADIP PF11559.8 KOO34079.1 - 10 6.2 11.0 0.32 11.1 2.9 2.3 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Pkinase PF00069.25 KOO34080.1 - 5.8e-61 206.2 0.0 6.8e-61 205.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34080.1 - 2.5e-30 105.6 0.0 3.1e-30 105.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO34080.1 - 1.5e-05 25.0 0.7 0.011 15.6 0.2 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KOO34080.1 - 7.9e-05 22.1 0.2 0.00015 21.2 0.2 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO34080.1 - 0.00016 21.1 0.0 0.001 18.4 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO34080.1 - 0.011 14.6 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase AIP3 PF03915.13 KOO34080.1 - 0.097 11.7 0.1 0.13 11.3 0.1 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 Pantoate_transf PF02548.15 KOO34081.1 - 3.7e-108 360.8 0.6 6e-108 360.1 0.6 1.3 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase Pantoate_ligase PF02569.15 KOO34081.1 - 1.2e-89 300.1 0.0 1.8e-89 299.5 0.0 1.3 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase PEP_mutase PF13714.6 KOO34081.1 - 4e-07 29.7 0.2 4e-07 29.7 0.2 1.9 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DUF4861 PF16153.5 KOO34081.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4861) AIRS PF00586.24 KOO34081.1 - 1.9 9.2 5.1 7.2 7.3 0.6 3.2 3 0 0 3 3 3 0 AIR synthase related protein, N-terminal domain HI0933_like PF03486.14 KOO34082.1 - 2.5e-84 283.4 0.0 8.2e-47 159.8 0.0 2.0 1 1 1 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 KOO34082.1 - 5.7e-06 25.7 2.7 1.3e-05 24.5 0.8 2.3 2 1 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 KOO34082.1 - 4.5e-05 22.8 0.2 0.037 13.3 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOO34082.1 - 0.00027 20.2 1.1 0.39 9.8 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A DAO PF01266.24 KOO34082.1 - 0.00063 19.4 4.7 0.23 11.0 0.2 2.7 2 1 1 3 3 3 2 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 KOO34082.1 - 0.00064 19.1 0.1 0.0011 18.3 0.1 1.5 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 KOO34082.1 - 0.0014 18.1 0.2 0.0019 17.6 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KOO34082.1 - 0.0019 17.3 0.2 0.003 16.7 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 KOO34082.1 - 0.033 14.7 0.2 4.3 8.0 0.0 2.6 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF4224 PF13986.6 KOO34082.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) NAD_binding_8 PF13450.6 KOO34082.1 - 0.36 11.1 1.9 0.43 10.8 0.3 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HSP70 PF00012.20 KOO34083.1 - 1.6e-62 211.6 0.1 1.8e-51 175.1 0.0 2.9 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 KOO34083.1 - 1.9e-15 56.5 1.6 7.4e-15 54.6 0.4 2.4 2 1 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KOO34083.1 - 0.012 15.3 0.4 0.031 14.0 0.4 1.7 1 1 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 KOO34083.1 - 0.19 11.0 0.0 0.29 10.3 0.0 1.3 1 0 0 1 1 1 0 StbA protein DUF1917 PF08939.10 KOO34084.1 - 0.15 11.9 0.1 0.22 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) MRI PF15325.6 KOO34084.1 - 6.3 7.9 6.2 1 10.5 0.4 2.6 3 1 0 3 3 3 0 Modulator of retrovirus infection EF-hand_7 PF13499.6 KOO34086.1 - 6.9e-24 84.1 3.4 9.6e-13 48.4 0.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO34086.1 - 1.1e-19 68.4 8.0 1.2e-06 27.6 1.1 4.8 4 1 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO34086.1 - 8.6e-18 62.7 2.7 0.00053 19.7 0.0 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO34086.1 - 1.2e-15 57.1 6.6 3.7e-08 33.1 0.2 3.8 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO34086.1 - 6e-09 35.0 11.4 0.001 18.4 0.4 4.4 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KOO34086.1 - 5.8e-07 29.7 0.0 0.0055 17.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SurA_N_3 PF13624.6 KOO34086.1 - 1.7e-05 24.7 2.1 0.0046 16.8 0.9 2.1 2 0 0 2 2 2 2 SurA N-terminal domain Dockerin_1 PF00404.18 KOO34086.1 - 0.00099 19.3 0.1 0.033 14.4 0.0 2.7 1 1 2 3 3 3 1 Dockerin type I domain SurA_N_2 PF13623.6 KOO34086.1 - 0.013 15.3 0.9 2.5 8.0 0.3 2.3 1 1 1 2 2 2 0 SurA N-terminal domain RNase_H_2 PF13482.6 KOO34086.1 - 0.026 14.5 0.1 2.9 7.8 0.0 2.1 1 1 1 2 2 2 0 RNase_H superfamily SPARC_Ca_bdg PF10591.9 KOO34086.1 - 0.028 14.7 1.0 0.12 12.7 1.2 1.8 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3349 PF11829.8 KOO34086.1 - 0.094 13.5 0.6 1 10.2 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) DUF2267 PF10025.9 KOO34086.1 - 0.1 12.9 1.2 1.3 9.4 1.2 2.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) Toprim_2 PF13155.6 KOO34086.1 - 0.12 12.8 1.0 10 6.6 0.0 2.8 1 1 2 3 3 3 0 Toprim-like DUF179 PF02622.15 KOO34087.1 - 5.3e-14 52.5 0.0 1.7e-13 50.8 0.0 1.8 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 Nucleotid_trans PF03407.16 KOO34088.1 - 5.4e-39 134.4 0.0 7.7e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ATP-synt_ab PF00006.25 KOO34089.1 - 2.9e-102 340.8 0.0 4.4e-102 340.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 KOO34089.1 - 1.6e-43 147.4 0.1 3.1e-43 146.5 0.1 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 KOO34089.1 - 1.5e-16 60.6 1.1 5.9e-16 58.7 1.1 2.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Presenilin PF01080.17 KOO34090.1 - 2.1 7.0 2.8 2.6 6.7 2.8 1.1 1 0 0 1 1 1 0 Presenilin Ax_dynein_light PF10211.9 KOO34090.1 - 3.7 7.5 10.6 0.054 13.4 1.4 1.9 1 1 0 2 2 2 0 Axonemal dynein light chain Glutaredoxin PF00462.24 KOO34091.1 - 2.9e-15 56.2 0.0 4.1e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin EF-hand_6 PF13405.6 KOO34093.1 - 6.2e-19 66.2 5.1 3.1e-06 26.7 0.1 5.3 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 KOO34093.1 - 3.6e-17 60.5 8.5 1.5e-05 24.2 0.1 5.4 7 0 0 7 7 7 4 EF hand EF-hand_7 PF13499.6 KOO34093.1 - 1.1e-13 51.4 5.3 0.00013 22.3 0.3 4.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO34093.1 - 5.4e-09 35.2 6.6 0.012 15.1 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO34093.1 - 1.9e-08 34.0 4.2 0.0058 16.4 0.1 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO34093.1 - 0.033 14.5 0.0 5.2 7.5 0.0 3.4 3 0 0 3 3 3 0 EF-hand domain Caleosin PF05042.13 KOO34093.1 - 0.069 13.1 0.0 3.8 7.4 0.0 2.6 2 1 1 3 3 3 0 Caleosin related protein BAF1_ABF1 PF04684.13 KOO34095.1 - 3.9 6.4 10.4 0.28 10.2 2.8 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Aa_trans PF01490.18 KOO34096.1 - 7.5e-20 71.0 8.7 4.9e-19 68.3 8.7 1.8 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF373 PF04123.13 KOO34096.1 - 0.39 10.1 3.4 0.32 10.4 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF373) Aa_trans PF01490.18 KOO34097.1 - 4.4e-26 91.5 18.3 3.9e-25 88.4 18.3 2.1 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.18 KOO34098.1 - 0.0016 17.2 1.2 0.0017 17.2 1.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Myosin_head PF00063.21 KOO34099.1 - 2.6e-163 544.8 0.0 3e-85 286.8 0.0 2.2 1 1 1 2 2 2 2 Myosin head (motor domain) AAA_16 PF13191.6 KOO34099.1 - 0.011 16.1 0.1 0.011 16.1 0.1 2.8 3 2 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 KOO34099.1 - 0.02 15.2 0.2 0.16 12.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 KOO34099.1 - 0.092 12.4 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Tho2 PF11262.8 KOO34099.1 - 0.22 10.7 3.4 0.36 10.0 3.4 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Pkinase PF00069.25 KOO34100.1 - 4.2e-50 170.6 0.0 6.1e-50 170.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34100.1 - 1.3e-45 155.7 0.0 1.9e-45 155.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO34100.1 - 0.011 14.5 0.0 0.022 13.6 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Keratin_matx PF04579.12 KOO34100.1 - 0.046 14.1 1.0 0.1 12.9 1.0 1.5 1 0 0 1 1 1 0 Keratin, high-sulphur matrix protein Serglycin PF04360.12 KOO34100.1 - 2.2 8.2 4.0 1.9 8.4 1.9 1.9 2 0 0 2 2 2 0 Serglycin FKBP_C PF00254.28 KOO34101.1 - 1.4e-13 51.0 0.0 2.5e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_5 PF13202.6 KOO34101.1 - 8.4e-08 31.4 3.3 0.00088 18.7 0.3 2.7 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KOO34101.1 - 2.2e-07 29.9 1.2 0.017 14.6 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34101.1 - 2.6e-06 27.8 1.1 3.9e-06 27.2 0.2 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO34101.1 - 9.2e-05 22.2 0.3 0.076 12.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO34101.1 - 0.00037 20.2 4.0 0.53 10.4 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain Helicase_C PF00271.31 KOO34103.1 - 1.4e-28 99.4 0.8 2.2e-28 98.8 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO34103.1 - 6e-12 45.7 0.0 1.6e-11 44.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase CMS1 PF14617.6 KOO34103.1 - 0.15 11.3 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit UTP25 PF06862.12 KOO34103.1 - 0.16 10.7 0.0 2.9 6.6 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Aminotran_3 PF00202.21 KOO34104.1 - 7.8e-17 61.0 0.3 1.1e-16 60.5 0.3 1.1 1 0 0 1 1 1 1 Aminotransferase class-III zf-ANAPC11 PF12861.7 KOO34105.1 - 3.1e-29 100.9 8.4 3.9e-29 100.6 8.4 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KOO34105.1 - 1.9e-19 69.7 6.2 3e-19 69.0 6.2 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KOO34105.1 - 1.6e-07 31.6 9.9 1.6e-07 31.6 9.9 2.2 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO34105.1 - 1.7e-07 30.9 3.1 1.7e-07 30.9 3.1 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO34105.1 - 1.9e-06 27.7 2.8 1.9e-06 27.7 2.8 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOO34105.1 - 2e-05 24.4 1.7 2e-05 24.4 1.7 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO34105.1 - 7.1e-05 22.8 1.5 0.00028 20.8 0.7 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-P11 PF03854.14 KOO34105.1 - 0.00027 20.5 6.1 0.0068 16.0 2.1 2.2 2 0 0 2 2 2 2 P-11 zinc finger Prok-RING_4 PF14447.6 KOO34105.1 - 0.00065 19.5 0.7 0.00065 19.5 0.7 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KOO34105.1 - 0.0014 18.5 7.1 0.016 15.0 7.4 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOO34105.1 - 0.0074 16.0 0.1 0.0074 16.0 0.1 2.8 3 0 0 3 3 3 1 RING-like zinc finger zf-Nse PF11789.8 KOO34105.1 - 0.011 15.5 0.8 0.023 14.5 0.8 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RecR PF02132.15 KOO34105.1 - 0.028 14.0 0.8 2.4 7.8 0.1 2.3 2 0 0 2 2 2 0 RecR protein zf-RING_4 PF14570.6 KOO34105.1 - 0.046 13.5 1.6 0.046 13.5 1.6 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain TerY_C PF15616.6 KOO34105.1 - 0.22 11.6 1.7 0.25 11.5 1.0 1.5 1 1 0 1 1 1 0 TerY-C metal binding domain Nucleotid_trans PF03407.16 KOO34106.1 - 8e-17 61.9 0.0 2.7e-16 60.2 0.0 1.8 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase Glyco_transf_8 PF01501.20 KOO34106.1 - 0.2 11.2 0.0 0.6 9.6 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferase family 8 Ank_2 PF12796.7 KOO34107.1 - 3.1e-22 79.0 0.0 4.1e-14 52.9 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34107.1 - 1.7e-13 50.7 0.1 1.6e-09 38.1 0.0 3.9 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO34107.1 - 2.4e-11 43.5 3.1 0.0017 18.7 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 KOO34107.1 - 4.8e-11 41.9 1.5 0.0067 16.8 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 KOO34107.1 - 7.6e-10 38.9 1.9 0.0023 18.2 0.0 4.0 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Glyoxalase_6 PF18029.1 KOO34107.1 - 1 10.2 0.0 1 10.2 0.0 2.9 4 1 0 4 4 4 0 Glyoxalase-like domain Gly_transf_sug PF04488.15 KOO34109.1 - 5.5e-05 23.7 0.0 0.00012 22.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 KOO34109.1 - 0.00026 20.5 0.0 0.00034 20.1 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.7 KOO34109.1 - 0.026 13.9 0.0 0.035 13.4 0.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain adh_short PF00106.25 KOO34110.1 - 1.3e-07 31.2 0.0 4.6e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 short chain dehydrogenase baeRF_family12 PF18856.1 KOO34111.1 - 0.32 11.6 8.1 0.066 13.8 3.3 2.2 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 IPPT PF01715.17 KOO34112.1 - 3.5e-62 210.2 0.0 8.7e-62 208.9 0.0 1.6 2 0 0 2 2 2 1 IPP transferase LVIVD PF08309.11 KOO34113.1 - 1.4e-53 178.0 54.0 5.5e-11 41.6 2.1 6.4 6 0 0 6 6 6 6 LVIVD repeat Laminin_G_3 PF13385.6 KOO34113.1 - 1.3e-09 38.3 0.1 3.2e-09 37.1 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily PSCyt3 PF07627.11 KOO34113.1 - 1.8e-07 31.4 0.0 4.3 7.7 0.0 5.0 2 1 3 5 5 5 4 Protein of unknown function (DUF1588) SBP56 PF05694.11 KOO34113.1 - 0.0027 16.6 0.3 0.85 8.4 0.0 3.3 1 1 1 3 3 3 2 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 KOO34113.1 - 0.011 15.0 1.7 0.89 8.7 0.3 2.3 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Beta_propel PF09826.9 KOO34113.1 - 0.039 12.8 0.1 72 2.0 0.0 4.0 4 1 0 4 4 4 0 Beta propeller domain ELFV_dehydrog_N PF02812.18 KOO34116.1 - 0.13 12.2 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Myb_DNA-binding PF00249.31 KOO34117.1 - 4.5e-06 26.8 6.4 7.1e-05 22.9 0.5 3.1 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO34117.1 - 1.3e-05 25.3 0.5 6.6e-05 23.1 0.3 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain HTH_38 PF13936.6 KOO34117.1 - 0.3 10.9 1.6 0.43 10.4 0.3 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain VWA_2 PF13519.6 KOO34118.1 - 3.9e-05 24.3 0.0 9.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 KOO34118.1 - 0.0041 17.4 0.0 0.0073 16.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain PX PF00787.24 KOO34119.1 - 1.2e-12 47.8 0.2 2e-12 47.1 0.2 1.4 1 0 0 1 1 1 1 PX domain RUN PF02759.19 KOO34119.1 - 4.1e-11 43.0 0.5 9.6e-11 41.8 0.1 1.8 2 0 0 2 2 2 1 RUN domain CtaG_Cox11 PF04442.14 KOO34120.1 - 9.8e-60 201.0 0.0 1.1e-59 200.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 FHA PF00498.26 KOO34123.1 - 3.7e-11 43.2 0.0 5.8e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO34123.1 - 0.04 14.2 0.0 0.093 13.1 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain EF-hand_1 PF00036.32 KOO34126.1 - 2.4e-07 29.8 0.2 2.4e-07 29.8 0.2 1.9 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO34126.1 - 1.7e-06 27.2 0.2 1.7e-06 27.2 0.2 1.8 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO34126.1 - 6e-05 22.7 0.2 6e-05 22.7 0.2 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 KOO34126.1 - 0.0002 21.1 0.1 0.0002 21.1 0.1 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 KOO34126.1 - 0.0042 17.5 1.2 0.0057 17.1 1.2 1.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO34127.1 - 1.8e-19 67.7 2.0 1.8e-05 23.9 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO34127.1 - 5.7e-17 61.9 2.8 4.6e-10 39.8 0.1 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO34127.1 - 5.1e-15 54.0 0.1 0.0027 17.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO34127.1 - 4.6e-14 51.2 4.4 0.0011 18.3 0.1 3.7 3 0 0 3 3 3 3 EF hand PDZ PF00595.24 KOO34127.1 - 8.3e-14 51.7 0.1 5.7e-06 26.6 0.0 3.5 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 KOO34127.1 - 4.7e-12 45.6 0.1 5.7e-08 32.5 0.0 2.8 2 0 0 2 2 2 2 PDZ domain EF-hand_8 PF13833.6 KOO34127.1 - 7.5e-10 38.5 4.9 1.5e-06 27.9 0.7 3.1 2 1 1 3 3 3 2 EF-hand domain pair PDZ_2 PF13180.6 KOO34127.1 - 2.1e-07 31.1 0.0 0.0067 16.7 0.0 2.8 2 0 0 2 2 2 2 PDZ domain SPARC_Ca_bdg PF10591.9 KOO34127.1 - 9.7e-06 25.9 0.0 0.16 12.3 0.0 2.5 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO34127.1 - 3.8e-05 23.6 0.2 0.25 11.3 0.1 2.7 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO34127.1 - 0.0014 18.8 1.6 0.09 13.0 0.1 2.7 2 1 0 2 2 2 1 Dockerin type I domain EF-hand_9 PF14658.6 KOO34127.1 - 0.016 15.5 0.4 1.3 9.4 0.0 2.8 3 0 0 3 3 2 0 EF-hand domain Tricorn_PDZ PF14685.6 KOO34127.1 - 0.025 14.5 0.1 0.094 12.7 0.0 2.0 2 0 0 2 2 2 0 Tricorn protease PDZ domain DUF2939 PF11159.8 KOO34127.1 - 0.92 10.0 5.9 4.9 7.6 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2939) Bac_DNA_binding PF00216.21 KOO34128.1 - 2.2e-28 98.3 0.3 2.5e-28 98.1 0.3 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 KOO34128.1 - 5e-08 33.1 0.0 6.2e-08 32.8 0.0 1.0 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif LacI PF00356.21 KOO34128.1 - 0.049 13.4 1.7 0.089 12.6 1.7 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family S1-like PF14444.6 KOO34128.1 - 0.095 12.6 0.1 7.6 6.5 0.0 2.3 2 0 0 2 2 2 0 S1-like HU-CCDC81_bac_2 PF18175.1 KOO34128.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 ATG16 PF08614.11 KOO34130.1 - 0.01 16.1 0.9 0.015 15.5 0.9 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Bcr-Abl_Oligo PF09036.10 KOO34130.1 - 0.052 13.6 1.4 0.15 12.1 0.3 2.1 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Spc7 PF08317.11 KOO34130.1 - 0.31 9.9 2.8 0.53 9.1 2.8 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein Totivirus_coat PF05518.11 KOO34130.1 - 6 4.8 6.2 7.2 4.5 6.2 1.1 1 0 0 1 1 1 0 Totivirus coat protein SPRY PF00622.28 KOO34131.1 - 9.7e-06 25.7 0.0 0.1 12.7 0.0 2.3 2 0 0 2 2 2 2 SPRY domain LRR_6 PF13516.6 KOO34131.1 - 0.0015 18.5 1.1 11 6.3 0.0 5.2 6 0 0 6 6 6 1 Leucine Rich repeat 60KD_IMP PF02096.20 KOO34133.1 - 7.3e-52 175.6 0.2 9.2e-52 175.3 0.2 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein Bmt2 PF11968.8 KOO34134.1 - 3.1e-07 30.5 0.0 0.00086 19.2 0.0 2.1 2 0 0 2 2 2 2 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_12 PF08242.12 KOO34134.1 - 0.054 14.2 0.0 0.11 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TMA7 PF09072.10 KOO34135.1 - 0.0066 17.3 3.9 0.014 16.2 3.9 1.5 1 0 0 1 1 1 1 Translation machinery associated TMA7 LRR_6 PF13516.6 KOO34136.1 - 8.8e-15 53.4 10.7 0.002 18.0 0.6 7.6 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 KOO34136.1 - 1.2e-06 28.8 0.9 4.1 8.0 0.0 4.4 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO34136.1 - 0.00012 21.8 0.3 2.2 8.1 0.0 4.7 5 1 0 5 5 5 2 Leucine rich repeat LRR_1 PF00560.33 KOO34136.1 - 0.0039 17.5 0.0 49 5.1 0.1 4.8 7 0 0 7 7 7 0 Leucine Rich Repeat DUF3506 PF12014.8 KOO34138.1 - 2e-06 27.9 0.0 3e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) LRR_4 PF12799.7 KOO34141.1 - 0.00028 21.2 0.8 0.012 16.0 0.1 3.5 5 0 0 5 5 5 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO34141.1 - 0.0016 18.1 0.6 0.048 13.4 0.1 3.6 5 1 0 5 5 5 1 Leucine rich repeat LRR_1 PF00560.33 KOO34141.1 - 0.039 14.5 1.9 1.9 9.3 0.0 4.2 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.6 KOO34141.1 - 0.059 13.5 4.7 2.1 8.6 0.0 4.4 5 0 0 5 5 5 0 Leucine Rich repeat O-FucT PF10250.9 KOO34143.1 - 7.3e-05 22.6 0.0 0.00064 19.5 0.0 1.9 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase TMEM18 PF14770.6 KOO34144.1 - 5e-44 149.1 0.9 6.7e-44 148.7 0.9 1.1 1 0 0 1 1 1 1 Transmembrane protein 18 HCV_env PF01539.17 KOO34144.1 - 0.069 12.8 0.5 0.084 12.6 0.5 1.1 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 DAGK_prokar PF01219.19 KOO34144.1 - 0.11 12.3 0.4 0.11 12.3 0.4 1.6 2 0 0 2 2 2 0 Prokaryotic diacylglycerol kinase ECM1 PF05782.11 KOO34145.1 - 0.026 13.5 5.2 0.033 13.2 5.2 1.0 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) DUF1779 PF08680.10 KOO34145.1 - 0.37 10.9 3.0 0.36 11.0 2.0 1.5 1 1 0 1 1 1 0 TATA-box binding FAD_binding_3 PF01494.19 KOO34146.1 - 2.9e-08 33.4 1.3 2.3e-07 30.4 1.3 2.3 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 KOO34146.1 - 0.00019 20.3 0.0 0.00028 19.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 KOO34146.1 - 0.0004 20.5 0.0 0.00087 19.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO34146.1 - 0.00087 19.0 0.1 0.0013 18.4 0.1 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Glu_dehyd_C PF16912.5 KOO34146.1 - 0.0036 16.8 0.0 0.0089 15.5 0.0 1.6 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus Pyr_redox_2 PF07992.14 KOO34146.1 - 0.011 15.0 0.0 0.021 14.1 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RskA PF10099.9 KOO34146.1 - 0.023 15.0 3.0 0.44 10.8 0.1 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Lycopene_cycl PF05834.12 KOO34146.1 - 0.041 12.9 0.2 0.078 12.0 0.0 1.4 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 KOO34146.1 - 0.052 12.6 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain CPT_N PF16484.5 KOO34146.1 - 0.06 13.3 0.1 0.35 10.9 0.0 2.3 3 0 0 3 3 3 0 Carnitine O-palmitoyltransferase N-terminus NAD_binding_9 PF13454.6 KOO34146.1 - 0.11 12.5 0.0 0.56 10.2 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 KOO34146.1 - 0.16 11.2 0.7 0.23 10.7 0.2 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase T3SSipB PF16535.5 KOO34147.1 - 1.1 9.7 4.0 1.7 9.1 0.0 2.7 3 0 0 3 3 3 0 Type III cell invasion protein SipB Na_Ca_ex PF01699.24 KOO34148.1 - 6.1e-41 139.9 32.4 2.5e-22 79.5 12.5 2.9 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Calx-beta PF03160.14 KOO34148.1 - 1.2e-20 73.5 0.1 1e-17 64.1 0.3 2.7 3 0 0 3 3 3 2 Calx-beta domain UCR_hinge PF02320.16 KOO34148.1 - 3.3e-08 33.6 0.2 6.4e-08 32.7 0.2 1.5 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein DCR PF14047.6 KOO34148.1 - 0.049 13.8 0.1 0.34 11.2 0.0 2.3 2 0 0 2 2 2 0 Dppa2/4 conserved region CX9C PF16860.5 KOO34148.1 - 0.45 10.6 1.5 1.3 9.1 0.3 2.1 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, WD40 PF00400.32 KOO34149.1 - 0.079 13.9 0.1 0.24 12.3 0.0 1.8 2 0 0 2 2 2 0 WD domain, G-beta repeat MspA PF09203.11 KOO34149.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.4 1 1 0 1 1 1 0 MspA HAT_KAT11 PF08214.11 KOO34151.1 - 8.7e-26 91.0 0.7 3.4e-25 89.1 0.7 1.8 1 1 0 1 1 1 1 Histone acetylation protein PHD PF00628.29 KOO34151.1 - 0.00023 21.0 18.4 0.00058 19.7 7.7 2.7 2 0 0 2 2 2 2 PHD-finger zf-CW PF07496.15 KOO34151.1 - 0.02 14.9 6.3 0.06 13.4 6.3 1.8 1 0 0 1 1 1 0 CW-type Zinc Finger PHD_2 PF13831.6 KOO34151.1 - 4.7 6.8 14.4 3.9 7.1 0.9 2.8 2 0 0 2 2 2 0 PHD-finger LRR_6 PF13516.6 KOO34152.1 - 1.3e-09 37.3 4.7 0.0064 16.5 0.1 5.0 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.7 KOO34152.1 - 0.0036 17.7 0.0 0.068 13.6 0.3 2.7 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) GlcNAc_2-epim PF07221.11 KOO34152.1 - 0.08 12.2 0.1 0.13 11.4 0.1 1.2 1 0 0 1 1 1 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) AMP-binding PF00501.28 KOO34153.1 - 3.7e-62 210.3 0.0 4.7e-62 209.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 KOO34154.1 - 2.3e-19 69.5 0.0 4.3e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 KOO34154.1 - 0.0014 19.0 0.0 0.64 10.4 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site DUF2321 PF10083.9 KOO34155.1 - 0.047 13.3 0.8 0.064 12.9 0.8 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-HYPF PF07503.12 KOO34157.1 - 0.25 11.2 7.2 1.3 8.9 1.2 2.6 2 0 0 2 2 2 0 HypF finger Lipase_GDSL_2 PF13472.6 KOO34159.1 - 0.0017 18.8 0.0 0.0027 18.1 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Ax_dynein_light PF10211.9 KOO34160.1 - 9.9e-35 120.2 0.2 1.4e-34 119.7 0.2 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain DUF3818 PF12825.7 KOO34160.1 - 0.1 11.6 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) DUF4909 PF16253.5 KOO34160.1 - 0.2 11.5 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4909) PKD_channel PF08016.12 KOO34161.1 - 2.2e-49 168.3 25.9 1.5e-38 132.6 23.3 2.1 2 0 0 2 2 2 2 Polycystin cation channel Ion_trans PF00520.31 KOO34161.1 - 3.7e-10 39.4 24.5 5.7e-10 38.8 24.5 1.3 1 0 0 1 1 1 1 Ion transport protein SARAF PF06682.12 KOO34161.1 - 0.042 13.5 0.0 0.074 12.7 0.0 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis OppC_N PF12911.7 KOO34161.1 - 0.25 11.4 4.3 3.2 7.8 0.7 2.8 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DUF4834 PF16118.5 KOO34161.1 - 0.32 12.0 1.9 0.79 10.7 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) HemY_N PF07219.13 KOO34161.1 - 2.4 8.4 4.8 0.95 9.7 0.4 2.6 2 0 0 2 2 2 0 HemY protein N-terminus TMEM208_SND2 PF05620.11 KOO34161.1 - 4.1 7.1 6.9 3.9 7.2 0.6 3.0 2 1 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 FUN14 PF04930.15 KOO34162.1 - 2.3e-22 79.2 0.7 4.2e-22 78.4 0.7 1.4 1 0 0 1 1 1 1 FUN14 family EF-hand_1 PF00036.32 KOO34162.1 - 0.01 15.3 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 EF hand Dockerin_1 PF00404.18 KOO34162.1 - 0.012 15.8 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 Dockerin type I domain EF-hand_6 PF13405.6 KOO34162.1 - 0.017 15.0 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 KOO34162.1 - 0.035 13.6 0.0 0.063 12.8 0.0 1.3 1 0 0 1 1 1 0 EF hand Tim17 PF02466.19 KOO34163.1 - 6e-18 65.2 5.6 7.8e-18 64.9 5.6 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF418 PF04235.12 KOO34163.1 - 0.064 13.2 0.8 0.083 12.8 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF418) NARP1 PF12569.8 KOO34166.1 - 1.7e-187 624.5 19.5 1.4e-186 621.4 15.6 2.2 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 KOO34166.1 - 7.8e-12 44.4 26.2 0.0028 17.6 0.1 9.3 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO34166.1 - 9.2e-08 32.3 41.9 0.0073 17.0 0.6 9.6 9 2 2 11 11 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO34166.1 - 2.3e-07 30.5 10.4 0.25 11.7 0.0 7.3 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34166.1 - 7.9e-07 28.6 15.8 0.052 13.4 0.1 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 KOO34166.1 - 4.3e-06 26.1 14.8 0.012 14.9 0.0 4.5 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO34166.1 - 4.7e-06 26.2 2.0 0.041 13.6 0.0 4.3 5 0 0 5 5 5 2 TPR repeat TPR_19 PF14559.6 KOO34166.1 - 0.0001 22.8 40.2 0.015 15.8 0.7 9.1 7 2 2 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO34166.1 - 0.00011 22.3 7.7 19 5.9 0.1 8.9 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO34166.1 - 0.00019 21.2 12.0 0.15 12.2 0.1 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO34166.1 - 0.00019 22.0 0.3 0.0019 18.8 1.5 9.6 9 1 1 10 10 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO34166.1 - 0.0026 18.0 14.1 0.37 11.0 0.1 5.9 5 1 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 KOO34166.1 - 0.0057 16.7 6.9 0.34 11.0 0.1 4.6 5 1 1 6 6 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 KOO34166.1 - 0.078 13.1 26.1 1.2 9.3 2.3 6.0 7 1 1 8 8 7 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO34166.1 - 0.28 11.5 27.6 0.15 12.4 2.0 7.6 6 2 0 7 7 7 0 Tetratricopeptide repeat ISG65-75 PF11727.8 KOO34166.1 - 0.39 9.9 10.1 1.6 7.9 10.3 1.8 2 0 0 2 2 2 0 Invariant surface glycoprotein Coilin_N PF15862.5 KOO34166.1 - 4.3 7.1 6.3 16 5.3 6.1 1.9 2 0 0 2 2 2 0 Coilin N-terminus EF-hand_1 PF00036.32 KOO34167.1 - 5.3e-27 91.3 5.3 3.3e-05 23.1 0.0 6.5 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO34167.1 - 1.3e-22 77.7 3.2 0.00038 20.1 0.0 6.6 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.6 KOO34167.1 - 1.1e-20 73.8 1.8 2.2e-08 34.4 0.0 4.4 4 1 1 5 5 5 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO34167.1 - 1.8e-15 56.5 6.9 3e-06 27.0 0.1 5.9 5 1 1 6 6 6 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO34167.1 - 2.1e-13 49.1 9.7 9.1e-05 21.8 0.0 5.9 6 0 0 6 6 6 3 EF hand SPARC_Ca_bdg PF10591.9 KOO34167.1 - 0.001 19.4 0.0 0.077 13.3 0.0 3.0 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO34167.1 - 0.032 14.2 0.6 6.6 6.7 0.1 3.6 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand PAP_fibrillin PF04755.12 KOO34168.1 - 0.0039 17.1 0.0 0.0059 16.6 0.0 1.2 1 0 0 1 1 1 1 PAP_fibrillin E1_dh PF00676.20 KOO34169.1 - 3.2e-101 338.2 0.1 4e-101 337.9 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 KOO34169.1 - 1.7e-05 24.2 0.0 2.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 KOO34169.1 - 0.0014 18.4 0.6 0.0014 18.4 0.6 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CoaE PF01121.20 KOO34171.1 - 0.06 13.0 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase PIG-X PF08320.12 KOO34172.1 - 0.16 11.9 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 PIG-X / PBN1 EF-hand_6 PF13405.6 KOO34173.1 - 4.6e-35 116.5 16.1 3.1e-06 26.7 1.1 7.1 7 0 0 7 7 7 6 EF-hand domain EF-hand_1 PF00036.32 KOO34173.1 - 1.9e-34 114.6 17.6 1.8e-06 27.0 1.3 7.4 8 0 0 8 8 8 6 EF hand EF-hand_7 PF13499.6 KOO34173.1 - 7.7e-31 106.4 7.6 8.5e-09 35.7 0.1 4.2 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO34173.1 - 5e-25 87.1 9.3 0.00015 21.5 0.0 6.3 3 3 3 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO34173.1 - 4.1e-23 79.8 19.3 1.2e-06 27.7 2.0 7.6 7 0 0 7 7 7 6 EF hand EF-hand_9 PF14658.6 KOO34173.1 - 4.8e-05 23.6 0.6 1.2 9.6 0.0 4.7 4 1 0 4 4 4 1 EF-hand domain GPHH PF16905.5 KOO34173.1 - 0.00052 19.7 0.0 3.3 7.6 0.0 3.8 4 0 0 4 4 4 2 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_14 PF17959.1 KOO34173.1 - 0.0015 18.9 0.1 8.9 6.7 0.0 4.0 4 1 1 5 5 5 1 EF-hand domain EF-hand_10 PF14788.6 KOO34173.1 - 0.064 13.1 5.0 20 5.1 0.0 4.9 6 1 1 7 7 7 0 EF hand Caleosin PF05042.13 KOO34173.1 - 0.34 10.8 4.2 33 4.4 0.1 4.6 3 3 2 5 5 5 0 Caleosin related protein WD40 PF00400.32 KOO34175.1 - 6.7e-88 286.3 26.2 7e-10 39.3 0.5 9.2 9 0 0 9 9 9 9 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO34175.1 - 1.6e-30 106.2 15.0 0.0084 15.1 0.0 9.0 2 2 7 9 9 9 9 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO34175.1 - 3.2e-23 81.9 8.4 0.037 14.3 0.1 8.9 2 2 7 9 9 9 8 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO34175.1 - 1.4e-22 79.1 7.2 0.2 11.7 0.0 9.3 9 0 0 9 9 9 8 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO34175.1 - 1e-13 50.5 0.0 0.0058 15.0 0.0 5.7 2 2 1 5 5 5 3 WD repeat-containing and planar cell polarity effector protein Fritz BBS2_Mid PF14783.6 KOO34175.1 - 3e-11 43.3 0.7 0.093 12.8 0.0 6.6 2 2 3 6 6 6 2 Ciliary BBSome complex subunit 2, middle region DCX PF03607.17 KOO34175.1 - 6.1e-07 29.4 0.0 68 3.7 0.0 7.7 9 0 0 9 9 9 0 Doublecortin Nbas_N PF15492.6 KOO34175.1 - 6.7e-06 25.6 10.6 10 5.4 0.0 7.3 2 2 6 8 8 8 2 Neuroblastoma-amplified sequence, N terminal WD40_3 PF15911.5 KOO34175.1 - 0.00046 20.1 0.6 91 3.2 0.0 6.5 8 1 1 9 9 8 0 WD domain, G-beta repeat Utp8 PF10395.9 KOO34175.1 - 0.0069 15.0 1.4 3.1 6.2 0.2 3.8 2 2 3 5 5 5 1 Utp8 family Nucleoporin_N PF08801.11 KOO34175.1 - 0.016 14.0 8.1 1.1 7.9 0.1 4.3 2 2 1 3 3 3 0 Nup133 N terminal like Dfp1_Him1_M PF08630.10 KOO34175.1 - 0.022 15.0 8.7 14 5.9 0.0 5.7 8 0 0 8 8 8 0 Dfp1/Him1, central region DnaB_2 PF07261.11 KOO34175.1 - 0.036 13.8 0.4 12 5.7 0.1 2.9 2 0 0 2 2 2 0 Replication initiation and membrane attachment Plk4_PB1 PF18190.1 KOO34175.1 - 0.042 14.0 6.0 86 3.4 0.0 5.5 4 2 3 7 7 7 0 Polo-like Kinase 4 Polo Box 1 Cep57_MT_bd PF06657.13 KOO34175.1 - 0.083 13.4 0.1 63 4.1 0.0 3.5 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 KicB PF03882.14 KOO34175.1 - 0.11 12.8 1.2 10 6.4 0.1 2.3 2 0 0 2 2 2 0 MukF winged-helix domain RTTN_N PF14726.6 KOO34175.1 - 0.83 10.5 3.0 7 7.5 0.3 2.4 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning LRR_6 PF13516.6 KOO34176.1 - 2.1e-32 108.4 7.8 0.00068 19.5 0.1 9.4 9 0 0 9 9 9 6 Leucine Rich repeat LRR_4 PF12799.7 KOO34176.1 - 2e-10 40.7 0.0 0.0053 17.1 0.0 4.9 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO34176.1 - 5.1e-07 29.4 1.3 1.8 8.4 0.1 5.8 4 3 0 5 5 5 1 Leucine rich repeat LRR_1 PF00560.33 KOO34176.1 - 8.4e-05 22.6 0.0 2.6e+02 2.8 0.0 7.0 7 1 0 7 7 7 0 Leucine Rich Repeat EF-hand_7 PF13499.6 KOO34176.1 - 0.0014 19.1 0.1 0.0099 16.3 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO34176.1 - 0.0019 17.6 0.0 0.0044 16.5 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO34176.1 - 0.0039 17.0 0.0 0.012 15.4 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO34176.1 - 0.011 15.1 0.1 0.038 13.5 0.1 1.9 1 0 0 1 1 1 0 EF hand Borrelia_P83 PF05262.11 KOO34176.1 - 0.027 13.0 20.1 0.05 12.1 20.1 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein Golgin_A5 PF09787.9 KOO34176.1 - 0.11 11.9 16.5 0.17 11.3 16.5 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 V_ATPase_I PF01496.19 KOO34176.1 - 0.14 10.0 8.3 0.18 9.7 8.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-C4H2 PF10146.9 KOO34176.1 - 0.58 10.4 9.5 0.9 9.8 9.5 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein BNIP2 PF12496.8 KOO34176.1 - 0.82 10.1 3.9 1.6 9.1 3.9 1.4 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 NPV_P10 PF05531.12 KOO34176.1 - 2.3 8.7 6.4 4.7 7.7 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Phage_GPO PF05929.11 KOO34176.1 - 2.7 7.5 16.9 4.4 6.8 16.9 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Exonuc_VII_L PF02601.15 KOO34176.1 - 4.9 6.6 16.3 8.7 5.8 16.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_13 PF13166.6 KOO34176.1 - 5.2 5.6 15.4 7.1 5.1 15.4 1.1 1 0 0 1 1 1 0 AAA domain GTSE1_N PF15259.6 KOO34176.1 - 8.2 6.6 12.9 3.1 8.0 9.2 2.0 1 1 1 2 2 2 0 G-2 and S-phase expressed 1 EF-hand_5 PF13202.6 KOO34177.1 - 7.4e-10 37.9 0.4 0.00045 19.6 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO34177.1 - 1.1e-09 37.5 0.3 0.0006 19.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO34177.1 - 5.8e-09 34.9 0.3 0.00046 19.5 0.3 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34177.1 - 4.9e-07 30.1 0.2 1.4e-06 28.7 0.2 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO34177.1 - 1.3e-06 28.1 0.3 0.026 14.4 0.6 2.5 2 0 0 2 2 2 2 EF-hand domain pair Acyl-thio_N PF12590.8 KOO34178.1 - 0.028 15.0 0.1 0.037 14.6 0.1 1.2 1 0 0 1 1 1 0 Acyl-ATP thioesterase LCIB_C_CA PF18599.1 KOO34179.1 - 9e-77 257.3 0.0 1.2e-76 257.0 0.0 1.1 1 0 0 1 1 1 1 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases EF-hand_1 PF00036.32 KOO34179.1 - 1.2e-15 55.8 12.5 9.6e-07 27.9 1.5 3.8 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO34179.1 - 5.9e-14 51.6 4.8 2.3e-09 36.9 0.7 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO34179.1 - 6.7e-13 47.4 10.7 0.0015 18.3 1.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO34179.1 - 3.9e-11 43.3 3.0 1.1e-07 32.2 0.6 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO34179.1 - 4.8e-08 32.1 10.1 0.0079 15.6 0.2 3.7 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 KOO34179.1 - 0.0001 22.2 0.0 0.0003 20.7 0.0 1.7 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO34179.1 - 0.017 15.0 1.7 5.7 6.9 0.0 2.6 2 0 0 2 2 2 0 EF hand EF-hand_like PF09279.11 KOO34179.1 - 0.1 13.1 0.0 3.8 8.1 0.0 2.5 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like TIR_2 PF13676.6 KOO34180.1 - 8e-07 29.7 0.0 2.4e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 TIR domain Na_H_Exchanger PF00999.21 KOO34181.1 - 8.2e-40 136.8 36.5 1.2e-39 136.3 36.5 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Peptidase_M17_N PF02789.17 KOO34181.1 - 0.97 9.3 4.7 0.96 9.3 0.7 2.6 2 1 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain tRNA_SAD PF07973.14 KOO34184.1 - 1.3e-09 38.0 0.7 2.2e-09 37.3 0.7 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 KOO34184.1 - 0.0045 15.6 0.0 0.0059 15.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 KOO34184.1 - 0.016 15.6 5.1 0.037 14.5 5.1 1.6 1 0 0 1 1 1 0 DHHA1 domain La PF05383.17 KOO34185.1 - 6.7e-15 54.9 0.0 1.6e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 La domain DEAD PF00270.29 KOO34185.1 - 8.2e-15 55.0 0.0 2.1e-14 53.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase SPRY PF00622.28 KOO34185.1 - 5.1e-13 49.2 0.0 9.5e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 SPRY domain EF-hand_6 PF13405.6 KOO34185.1 - 3.6e-08 32.7 0.2 2.1e-05 24.1 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO34185.1 - 2.8e-07 29.6 0.0 0.0019 17.6 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34185.1 - 6.3e-07 29.7 0.0 2e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO34185.1 - 1.4e-05 24.8 0.0 0.0017 18.2 0.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair SH3_3 PF08239.11 KOO34185.1 - 0.00018 21.8 0.2 0.81 10.0 0.0 3.4 3 0 0 3 3 3 2 Bacterial SH3 domain EF-hand_5 PF13202.6 KOO34185.1 - 0.0015 18.0 0.0 0.26 10.8 0.0 2.7 2 0 0 2 2 2 1 EF hand adh_short PF00106.25 KOO34187.1 - 2.1e-33 115.5 0.0 2.6e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO34187.1 - 2.5e-23 82.9 0.0 3.4e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO34187.1 - 7.9e-06 25.9 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 KOO34187.1 - 0.00087 18.5 0.0 0.0011 18.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 KOO34187.1 - 0.01 15.2 0.0 0.025 14.0 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 KOO34187.1 - 0.083 12.3 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Esterase PF00756.20 KOO34188.1 - 0.00095 18.9 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 KOO34189.1 - 1.3e-06 28.3 0.0 1.5e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ndr PF03096.14 KOO34189.1 - 2.8e-05 23.0 0.1 3.9e-05 22.5 0.1 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_6 PF12697.7 KOO34189.1 - 7e-05 23.5 4.7 8.2e-05 23.3 4.7 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO34189.1 - 0.00025 20.4 0.0 0.00026 20.3 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 OTU PF02338.19 KOO34190.1 - 4.1e-08 33.8 0.4 5.8e-06 26.8 0.0 2.7 3 0 0 3 3 3 2 OTU-like cysteine protease Peptidase_C65 PF10275.9 KOO34190.1 - 0.23 10.9 2.0 1.2 8.5 0.0 2.5 2 1 0 3 3 3 0 Peptidase C65 Otubain Adeno_shaft PF00608.17 KOO34191.1 - 0.063 13.1 0.1 0.22 11.4 0.1 1.9 1 0 0 1 1 1 0 Adenoviral fibre protein (repeat/shaft region) E1-E2_ATPase PF00122.20 KOO34192.1 - 2.1e-46 157.7 3.4 7.1e-46 156.0 3.4 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 KOO34192.1 - 2.1e-18 67.4 1.1 2.1e-17 64.1 1.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOO34192.1 - 3.5e-11 42.6 0.0 8.7e-11 41.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOO34192.1 - 0.00053 19.8 0.3 0.0019 18.0 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Pur_ac_phosph_N PF16656.5 KOO34193.1 - 5.9e-07 30.0 0.3 1.5e-06 28.7 0.1 1.7 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 KOO34193.1 - 0.0014 19.2 0.0 1.6 9.2 0.0 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase Peptidase_C2 PF00648.21 KOO34194.1 - 4.1e-45 154.1 0.0 5.4e-45 153.7 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KOO34194.1 - 4e-16 59.6 0.0 1.5e-07 31.8 0.0 2.7 2 0 0 2 2 2 2 Calpain large subunit, domain III Helicase_C PF00271.31 KOO34195.1 - 6.4e-08 32.9 0.0 1.6e-07 31.6 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO34195.1 - 8.4e-07 28.9 0.0 4.5e-06 26.6 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase Ribosomal_L4 PF00573.22 KOO34195.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family TPR_10 PF13374.6 KOO34195.1 - 2.9 7.9 8.9 7.9 6.5 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat 2OG-FeII_Oxy_3 PF13640.6 KOO34196.1 - 3.2e-13 50.4 0.3 6.8e-13 49.3 0.1 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 KOO34196.1 - 5.2e-10 39.7 22.4 5.1e-06 26.9 3.5 3.0 4 0 0 4 4 4 2 ShK domain-like WW PF00397.26 KOO34196.1 - 1.5e-05 24.9 1.3 3e-05 24.0 1.3 1.5 1 0 0 1 1 1 1 WW domain Acatn PF13000.7 KOO34197.1 - 2.9e-96 323.2 1.3 6.9e-65 219.6 0.7 3.1 2 1 1 3 3 3 3 Acetyl-coenzyme A transporter 1 Jnk-SapK_ap_N PF09744.9 KOO34198.1 - 0.012 15.8 12.4 0.012 15.8 12.4 5.9 3 1 3 6 6 6 0 JNK_SAPK-associated protein-1 DUF4097 PF13349.6 KOO34199.1 - 0.26 10.6 0.0 0.31 10.4 0.0 1.1 1 0 0 1 1 1 0 Putative adhesin HET PF06985.11 KOO34200.1 - 0.11 12.9 0.2 0.91 9.9 0.0 2.2 1 1 1 2 2 2 0 Heterokaryon incompatibility protein (HET) DUF4126 PF13548.6 KOO34201.1 - 4e-27 95.0 22.8 4e-27 95.0 22.8 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4126) Peptidase_C2 PF00648.21 KOO34201.1 - 1.3e-06 27.7 0.0 1.8e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease NAD_binding_1 PF00175.21 KOO34203.1 - 3.7e-18 66.2 0.0 5.1e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOO34203.1 - 0.00011 22.4 0.0 0.0044 17.1 0.0 2.0 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Arm PF00514.23 KOO34205.1 - 5.5e-77 251.7 50.6 1.6e-08 34.3 0.3 12.9 13 0 0 13 13 13 11 Armadillo/beta-catenin-like repeat PARP PF00644.20 KOO34205.1 - 7.1e-09 35.5 0.1 2.3e-08 33.9 0.1 1.8 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain TM1506 PF08973.10 KOO34205.1 - 4.5e-06 26.4 0.0 63 3.2 0.0 8.1 2 2 7 9 9 9 0 Domain of unknown function (DUF1893) Arm_2 PF04826.13 KOO34205.1 - 0.0034 16.9 3.9 4.3 6.7 0.1 4.1 2 2 2 5 5 5 2 Armadillo-like HEAT_EZ PF13513.6 KOO34205.1 - 0.041 14.4 1.0 0.041 14.4 1.0 7.1 4 2 5 9 9 9 0 HEAT-like repeat UPF0561 PF10573.9 KOO34205.1 - 0.041 14.0 1.0 18 5.5 0.1 4.8 2 2 4 6 6 6 0 Uncharacterised protein family UPF0561 RHS_repeat PF05593.14 KOO34205.1 - 0.058 13.9 0.1 4.4 7.9 0.0 3.1 3 0 0 3 3 3 0 RHS Repeat SdiA-regulated PF06977.11 KOO34205.1 - 0.13 11.5 0.0 4.1 6.5 0.0 2.9 2 1 1 3 3 3 0 SdiA-regulated Reprolysin_5 PF13688.6 KOO34205.1 - 3 8.0 7.0 1.2e+02 2.8 0.0 4.7 1 1 2 4 4 4 0 Metallo-peptidase family M12 Thioredoxin PF00085.20 KOO34206.1 - 6.4e-09 35.7 0.0 9.8e-08 31.9 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin TraF PF13728.6 KOO34206.1 - 0.016 15.0 0.0 2 8.2 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein SIR2_2 PF13289.6 KOO34209.1 - 8.6e-20 71.3 0.0 1.7e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 SIR2-like domain DUF676 PF05057.14 KOO34210.1 - 2.9e-21 76.0 0.0 4.2e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PPR_2 PF13041.6 KOO34211.1 - 2.4e-15 56.5 0.0 1.7e-08 34.5 0.0 2.8 2 1 1 3 3 3 2 PPR repeat family PPR_1 PF12854.7 KOO34211.1 - 1.1e-09 37.8 0.3 0.00079 19.1 0.0 3.2 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 KOO34211.1 - 1.8e-09 37.5 0.0 6.7e-06 26.1 0.0 3.2 1 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO34211.1 - 3.5e-07 29.8 0.1 1.7e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 KOO34211.1 - 1.2e-06 28.4 2.9 0.11 12.7 0.0 4.3 5 0 0 5 5 5 2 PPR repeat PGM_PMM_I PF02878.16 KOO34213.1 - 2.3e-31 108.3 0.0 3.6e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 KOO34213.1 - 1.3e-24 86.6 0.0 2.4e-24 85.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 KOO34213.1 - 1.4e-10 41.7 0.0 3.7e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 KOO34213.1 - 1.4e-06 28.4 0.0 3.3e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain bPH_2 PF03703.14 KOO34214.1 - 1.3e-10 41.3 0.2 2.2e-10 40.6 0.2 1.3 1 0 0 1 1 1 1 Bacterial PH domain Trypan_PARP PF05887.11 KOO34216.1 - 0.5 10.3 22.0 0.8 9.7 21.0 1.9 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) Chloroa_b-bind PF00504.21 KOO34217.1 - 2.6e-32 112.6 0.0 3.4e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein RhoGEF PF00621.20 KOO34218.1 - 1.1e-23 84.4 0.0 1.3e-23 84.1 0.0 1.1 1 0 0 1 1 1 1 RhoGEF domain DUF3136 PF11334.8 KOO34219.1 - 0.1 12.4 0.0 0.32 10.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) Glycos_transf_2 PF00535.26 KOO34220.1 - 2.2e-13 50.4 0.0 2.5e-12 46.9 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 KOO34220.1 - 0.039 14.5 0.0 0.16 12.5 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 2 VID27_N PF17748.1 KOO34221.1 - 0.2 11.5 2.0 0.33 10.8 2.0 1.3 1 0 0 1 1 1 0 VID27 N-terminal region Pkinase PF00069.25 KOO34223.1 - 7e-47 160.0 0.0 1e-46 159.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34223.1 - 7.7e-40 136.8 0.0 1.3e-39 136.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO34223.1 - 1.6e-05 23.9 0.0 3e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO34223.1 - 0.0055 16.1 0.0 0.009 15.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like UTP25 PF06862.12 KOO34224.1 - 7.1e-31 107.5 0.0 1.2e-30 106.8 0.0 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF4326 PF14216.6 KOO34225.1 - 4.3e-11 43.4 0.0 1.4e-09 38.6 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4326) Phage_integrase PF00589.22 KOO34225.1 - 0.00059 19.7 0.1 0.042 13.6 0.0 2.3 2 0 0 2 2 2 2 Phage integrase family NmrA PF05368.13 KOO34226.1 - 6.6e-44 150.2 0.2 1.3e-43 149.2 0.2 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 KOO34226.1 - 6.8e-16 58.7 0.0 8.9e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOO34226.1 - 0.00015 21.4 0.0 0.0002 20.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 KOO34226.1 - 0.037 13.9 0.3 0.062 13.2 0.3 1.4 1 0 0 1 1 1 0 KR domain 3Beta_HSD PF01073.19 KOO34226.1 - 0.085 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 KOO34226.1 - 0.36 11.3 1.4 0.72 10.3 1.0 1.9 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Abhydrolase_1 PF00561.20 KOO34227.1 - 1.1e-18 67.8 0.1 7.3e-15 55.3 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOO34227.1 - 3.1e-18 67.2 3.4 4.8e-18 66.6 3.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO34227.1 - 7.6e-09 35.2 0.0 5.2e-08 32.4 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 KOO34227.1 - 4.9e-08 33.4 0.1 1e-07 32.3 0.0 1.6 2 0 0 2 2 2 1 Thioesterase domain LIDHydrolase PF10230.9 KOO34227.1 - 0.0084 15.7 0.0 0.011 15.2 0.0 1.3 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 KOO34227.1 - 0.045 13.6 0.0 0.14 12.0 0.0 1.8 1 1 0 1 1 1 0 Serine hydrolase Palm_thioest PF02089.15 KOO34227.1 - 0.048 13.5 0.0 0.055 13.3 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF3089 PF11288.8 KOO34227.1 - 0.057 13.0 0.0 0.095 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PGAP1 PF07819.13 KOO34227.1 - 0.25 11.1 0.1 23 4.6 0.0 2.2 1 1 1 2 2 2 0 PGAP1-like protein FAD-oxidase_C PF02913.19 KOO34228.1 - 8.1e-62 209.1 0.0 1.8e-61 207.9 0.0 1.6 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KOO34228.1 - 3.5e-34 117.5 3.3 6.1e-34 116.7 3.3 1.4 1 0 0 1 1 1 1 FAD binding domain Ank_2 PF12796.7 KOO34229.1 - 5.1e-79 260.9 21.6 1.4e-16 60.8 0.8 7.2 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34229.1 - 1.7e-55 184.7 21.7 5.4e-09 36.4 0.2 11.3 5 2 9 14 14 14 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO34229.1 - 2.8e-44 148.6 26.7 3.9e-07 30.2 0.3 9.9 3 3 4 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 KOO34229.1 - 3.2e-38 128.5 57.7 0.0011 19.3 0.1 13.6 13 0 0 13 13 13 11 Ankyrin repeat Ank_3 PF13606.6 KOO34229.1 - 1.3e-30 102.0 23.6 0.1 13.2 0.0 14.0 14 0 0 14 14 14 10 Ankyrin repeat Pkinase PF00069.25 KOO34229.1 - 1.2e-27 96.9 0.0 2.2e-27 96.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34229.1 - 5.9e-22 78.2 0.0 1.1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Prok-RING_1 PF14446.6 KOO34229.1 - 0.00016 21.6 7.0 17 5.4 0.0 7.9 10 0 0 10 10 10 0 Prokaryotic RING finger family 1 GREB1 PF15782.5 KOO34229.1 - 0.81 6.7 8.4 1.1 6.3 8.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer HPIP PF15226.6 KOO34229.1 - 3.1 8.2 9.1 0.35 11.3 1.1 2.9 3 0 0 3 3 3 0 HCF-1 beta-propeller-interacting protein family DUF2390 PF09523.10 KOO34229.1 - 8.4 6.8 8.6 4.7 7.6 2.3 3.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2390) Ank_2 PF12796.7 KOO34230.1 - 1.1e-31 109.2 8.8 3.8e-13 49.8 0.4 5.3 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34230.1 - 1.8e-27 95.3 6.2 1.1e-11 45.0 0.1 6.1 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 KOO34230.1 - 2.8e-19 68.6 24.8 0.00018 21.8 0.4 8.2 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 KOO34230.1 - 2e-18 66.2 14.2 4.3e-05 23.7 0.3 7.5 3 1 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34230.1 - 1.8e-16 58.5 10.0 0.004 17.5 0.1 8.8 7 1 1 8 8 8 4 Ankyrin repeat F-box-like PF12937.7 KOO34230.1 - 0.00027 20.8 0.2 0.0009 19.1 0.2 1.9 1 0 0 1 1 1 1 F-box-like RCC1 PF00415.18 KOO34231.1 - 2e-44 150.0 20.8 2.1e-11 44.2 0.4 7.9 6 2 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO34231.1 - 2.6e-33 113.1 35.3 3.1e-09 36.4 1.1 7.3 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Peroxin-13_N PF04088.13 KOO34232.1 - 0.1 12.9 0.1 0.2 11.9 0.1 1.5 1 1 0 1 1 1 0 Peroxin 13, N-terminal region Phage_P2_GpU PF06995.11 KOO34232.1 - 0.16 11.6 0.1 0.37 10.4 0.0 1.6 2 0 0 2 2 2 0 Phage P2 GpU SpoVS PF04232.12 KOO34233.1 - 7.8e-07 28.7 0.0 7.8e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 Stage V sporulation protein S (SpoVS) PDZ PF00595.24 KOO34234.1 - 1.7e-06 28.3 0.0 1.9e-06 28.1 0.0 1.0 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO34234.1 - 0.006 16.4 0.0 0.0092 15.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Carb_kinase PF01256.17 KOO34237.1 - 1.1e-46 159.4 0.0 1.3e-46 159.1 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 KOO34237.1 - 0.037 13.4 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase EF-hand_1 PF00036.32 KOO34238.1 - 3.2e-06 26.3 0.3 8.9e-06 24.9 0.2 1.9 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO34238.1 - 2.9e-05 23.6 0.1 0.00031 20.4 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO34238.1 - 0.0043 17.5 0.5 0.025 15.0 0.3 2.2 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO34238.1 - 0.015 14.8 0.9 0.032 13.7 0.3 1.9 2 0 0 2 2 2 0 EF hand Glyco_trans_1_2 PF13524.6 KOO34238.1 - 0.046 14.1 0.3 0.14 12.6 0.1 1.9 2 0 0 2 2 2 0 Glycosyl transferases group 1 TetR PF13972.6 KOO34239.1 - 0.13 12.0 1.1 0.27 11.0 0.1 1.9 2 0 0 2 2 2 0 Bacterial transcriptional repressor Hexapep_2 PF14602.6 KOO34240.1 - 0.037 13.8 0.4 0.12 12.2 0.4 1.9 1 0 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase Pkinase PF00069.25 KOO34243.1 - 3.1e-76 256.2 0.0 3.8e-76 255.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34243.1 - 2.1e-43 148.5 0.0 2.7e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO34243.1 - 2.2e-09 37.1 0.0 6.4e-09 35.5 0.0 1.7 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 KOO34243.1 - 7.6e-05 22.4 0.1 0.00012 21.7 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KOO34243.1 - 0.00035 20.0 0.1 0.0008 18.8 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO34243.1 - 0.0011 19.0 0.0 0.0026 17.7 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO34243.1 - 0.0021 17.1 0.0 0.0029 16.6 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain DUF1908 PF08926.11 KOO34243.1 - 0.0075 15.4 0.1 0.012 14.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1908) YukC PF10140.9 KOO34243.1 - 0.016 14.1 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC HTH_32 PF13565.6 KOO34243.1 - 0.02 15.5 1.3 0.048 14.3 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain Pkinase_fungal PF17667.1 KOO34243.1 - 0.031 13.1 0.0 0.067 12.0 0.0 1.3 1 1 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 KOO34243.1 - 0.17 11.4 0.1 0.3 10.6 0.1 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase adh_short PF00106.25 KOO34245.1 - 1.9e-09 37.2 0.0 3.2e-08 33.3 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO34245.1 - 1.3e-07 31.5 0.0 1.2e-06 28.3 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase LRR_6 PF13516.6 KOO34246.1 - 4.7e-14 51.2 7.8 0.00011 22.0 0.0 4.8 4 0 0 4 4 4 4 Leucine Rich repeat LRR_1 PF00560.33 KOO34246.1 - 0.00032 20.8 0.0 6.5 7.7 0.0 4.5 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO34246.1 - 0.00094 18.9 0.9 4.2 7.2 0.0 4.3 3 1 0 3 3 3 1 Leucine rich repeat NACHT PF05729.12 KOO34246.1 - 0.0039 17.1 0.0 0.01 15.8 0.0 1.7 1 0 0 1 1 1 1 NACHT domain LRR_4 PF12799.7 KOO34246.1 - 0.1 13.1 2.5 1.4 9.4 0.2 3.3 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) GCD14 PF08704.10 KOO34247.1 - 1.8e-51 175.2 0.0 2.2e-51 174.9 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 KOO34247.1 - 0.00012 21.9 0.1 0.00016 21.5 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 KOO34247.1 - 0.00019 22.4 0.2 0.0003 21.8 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO34247.1 - 0.00051 20.7 0.1 0.00086 20.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO34247.1 - 0.0034 17.2 0.0 0.0044 16.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 KOO34247.1 - 0.27 10.3 0.0 0.34 10.0 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Ndc1_Nup PF09531.10 KOO34248.1 - 4.9 5.7 7.3 5 5.7 7.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pkinase PF00069.25 KOO34251.1 - 3.1e-47 161.2 0.0 3.9e-47 160.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34251.1 - 7.4e-25 87.7 0.0 1e-24 87.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO34251.1 - 2.8e-06 26.9 0.0 3.9e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO34251.1 - 9e-06 25.8 0.1 9e-06 25.8 0.1 2.3 3 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO34251.1 - 0.0047 15.8 0.3 0.0059 15.4 0.3 1.4 1 1 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 KOO34251.1 - 0.18 11.4 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Peptidase_M8 PF01457.16 KOO34252.1 - 1.8e-86 290.9 0.0 3.5e-86 290.0 0.0 1.4 1 1 0 1 1 1 1 Leishmanolysin TIG PF01833.24 KOO34252.1 - 0.00026 21.0 0.0 0.00048 20.1 0.0 1.4 1 0 0 1 1 1 1 IPT/TIG domain DUF2818 PF10993.8 KOO34252.1 - 0.024 15.2 0.8 0.056 14.0 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2818) GAS2 PF02187.17 KOO34252.1 - 0.085 13.0 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 Growth-Arrest-Specific Protein 2 Domain Chloroa_b-bind PF00504.21 KOO34253.1 - 6e-30 104.9 0.0 8.3e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein LRR_6 PF13516.6 KOO34256.1 - 8.4e-26 87.8 6.1 0.00045 20.0 0.0 6.0 6 0 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.7 KOO34256.1 - 2.1e-09 37.5 2.5 0.018 15.5 0.0 4.8 2 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO34256.1 - 7.3e-06 25.8 0.0 58 4.8 0.0 5.8 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO34256.1 - 1.2e-05 25.0 3.8 0.56 10.0 0.0 5.2 1 1 4 5 5 5 2 Leucine rich repeat SpoU_sub_bind PF08032.12 KOO34256.1 - 1.5e-05 25.2 1.9 0.76 10.1 0.0 4.0 3 2 2 5 5 5 2 RNA 2'-O ribose methyltransferase substrate binding FAM25 PF15825.5 KOO34256.1 - 0.0035 17.6 8.8 2.4 8.6 0.2 4.3 4 0 0 4 4 4 1 FAM25 family CoatB PF10389.9 KOO34256.1 - 0.096 12.5 6.2 2.8 7.9 1.2 3.2 3 1 1 4 4 4 0 Bacteriophage coat protein B EIF_2_alpha PF07541.12 KOO34256.1 - 0.14 12.2 0.1 7.5 6.7 0.0 2.8 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit CbiG_N PF11760.8 KOO34256.1 - 0.55 10.3 13.9 6 6.9 0.1 4.4 3 2 2 5 5 5 0 Cobalamin synthesis G N-terminal Arm-DNA-bind_1 PF09003.10 KOO34256.1 - 0.93 9.7 6.9 28 4.9 0.1 3.8 4 1 0 4 4 4 0 Bacteriophage lambda integrase, Arm DNA-binding domain OapA_N PF08525.11 KOO34257.1 - 0.17 11.9 0.9 0.32 11.0 0.9 1.5 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif Chloroa_b-bind PF00504.21 KOO34258.1 - 5.4e-28 98.6 0.0 1.2e-27 97.4 0.0 1.5 1 1 0 1 1 1 1 Chlorophyll A-B binding protein Mating_N PF12731.7 KOO34259.1 - 0.016 15.3 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein beta 1 DUF2267 PF10025.9 KOO34259.1 - 0.057 13.7 0.0 0.065 13.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) PfUIS3 PF11567.8 KOO34259.1 - 0.12 12.7 0.0 0.34 11.3 0.0 1.8 1 1 0 1 1 1 0 Plasmodium falciparum UIS3 membrane protein Cupin_8 PF13621.6 KOO34260.1 - 3.2e-22 79.5 0.0 5.2e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain TPR_2 PF07719.17 KOO34260.1 - 9.1e-16 56.6 6.8 0.00083 19.3 0.0 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOO34260.1 - 3.5e-08 33.3 0.1 0.17 12.4 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO34260.1 - 3.6e-08 33.9 15.9 5.7e-05 23.7 0.4 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO34260.1 - 3e-07 30.7 14.7 0.027 15.3 1.0 5.3 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO34260.1 - 5.4e-06 26.6 7.1 0.021 15.1 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34260.1 - 9.6e-06 25.2 1.8 0.00067 19.4 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO34260.1 - 2.7e-05 23.8 6.5 0.00044 19.9 0.0 4.5 2 1 3 5 5 5 1 TPR repeat TPR_19 PF14559.6 KOO34260.1 - 2.7e-05 24.6 3.8 0.017 15.6 0.0 3.3 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO34260.1 - 3.3e-05 23.6 1.7 1.1 9.5 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO34260.1 - 9.4e-05 22.3 0.3 0.02 15.1 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat Cupin_4 PF08007.12 KOO34260.1 - 0.005 16.4 0.0 0.22 10.9 0.0 2.3 2 0 0 2 2 2 1 Cupin superfamily protein TPR_9 PF13371.6 KOO34260.1 - 0.011 15.8 0.5 0.011 15.8 0.5 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO34260.1 - 0.036 13.4 3.9 0.072 12.4 1.1 2.2 1 1 1 2 2 2 0 MalT-like TPR region TPR_4 PF07721.14 KOO34260.1 - 0.044 14.4 3.2 0.044 14.4 3.2 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO34260.1 - 0.062 13.2 13.0 0.29 11.1 0.0 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat NAD_binding_1 PF00175.21 KOO34261.1 - 4.4e-26 91.7 0.0 7e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOO34261.1 - 0.0023 18.3 0.0 0.0045 17.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain HEAT_EZ PF13513.6 KOO34262.1 - 0.001 19.5 5.2 0.53 10.8 0.3 4.4 4 0 0 4 4 4 2 HEAT-like repeat LisH PF08513.11 KOO34262.1 - 0.0077 16.2 0.2 0.017 15.1 0.2 1.6 1 0 0 1 1 1 1 LisH Arm PF00514.23 KOO34262.1 - 0.011 15.7 4.1 3 8.0 0.6 4.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat CCDC53 PF10152.9 KOO34263.1 - 0.19 12.2 6.8 4.5 7.7 0.1 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex RRM_1 PF00076.22 KOO34264.1 - 0.00017 21.3 0.1 0.0005 19.8 0.1 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dynamin_N PF00350.23 KOO34265.1 - 2.3e-24 86.3 0.0 3.2e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KOO34265.1 - 7.3e-05 22.8 0.0 0.00035 20.6 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 KOO34265.1 - 0.0027 17.1 0.1 1.2 8.4 0.0 2.4 2 0 0 2 2 2 2 AIG1 family Exonuc_VII_L PF02601.15 KOO34265.1 - 0.039 13.5 1.1 0.064 12.8 1.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit F_actin_bind PF08919.10 KOO34265.1 - 0.066 13.3 0.3 0.19 11.9 0.3 1.7 1 0 0 1 1 1 0 F-actin binding zf-CCCH PF00642.24 KOO34267.1 - 2.2e-08 33.8 0.4 3.3e-08 33.2 0.4 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOO34267.1 - 5.6e-06 26.2 3.2 8.2e-06 25.7 3.2 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KOO34267.1 - 9.7e-06 25.3 0.6 1.5e-05 24.7 0.6 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 KOO34267.1 - 0.0012 19.5 0.1 0.0018 19.0 0.1 1.2 1 0 0 1 1 1 1 Torus domain YjeF_N PF03853.15 KOO34267.1 - 0.0044 16.9 0.1 0.0057 16.6 0.1 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus PhyH PF05721.13 KOO34268.1 - 0.0029 17.9 0.0 0.0039 17.5 0.0 1.3 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Methyltransf_32 PF13679.6 KOO34272.1 - 0.013 15.5 0.0 0.015 15.3 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain AAA_7 PF12775.7 KOO34274.1 - 2.5e-16 59.7 0.0 3.9e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_lid_1 PF17857.1 KOO34274.1 - 4.1e-11 43.0 0.0 7.3e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_8 PF12780.7 KOO34275.1 - 3.4e-97 324.8 0.0 5.1e-97 324.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KOO34275.1 - 1.3e-81 272.9 0.0 1.3e-81 272.9 0.0 2.5 3 0 0 3 3 3 1 ATP-binding dynein motor region MT PF12777.7 KOO34275.1 - 6.4e-46 157.0 6.5 1.1e-45 156.2 6.5 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor PEARLI-4 PF05278.12 KOO34275.1 - 0.011 15.3 3.0 0.011 15.3 3.0 2.3 3 1 1 4 4 4 0 Arabidopsis phospholipase-like protein (PEARLI 4) Fez1 PF06818.15 KOO34275.1 - 0.19 12.2 10.4 0.2 12.1 0.8 2.6 2 0 0 2 2 2 0 Fez1 KIP1 PF07765.12 KOO34275.1 - 0.45 10.7 0.0 0.45 10.7 0.0 3.0 4 0 0 4 4 4 0 KIP1-like protein DUF3584 PF12128.8 KOO34275.1 - 1.1 6.7 8.0 1.8 6.0 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) ATG16 PF08614.11 KOO34275.1 - 1.2 9.3 11.1 0.11 12.7 2.1 2.6 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) UPF0242 PF06785.11 KOO34275.1 - 1.4 9.0 7.1 1.5 8.9 0.5 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Lebercilin PF15619.6 KOO34275.1 - 2.3 7.9 13.7 0.11 12.1 1.6 3.3 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Phage_GPO PF05929.11 KOO34275.1 - 4.6 6.8 12.7 0.12 12.0 0.6 3.1 2 1 1 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase Laminin_II PF06009.12 KOO34275.1 - 9.8 6.2 10.5 6.6 6.8 0.5 3.4 2 1 1 3 3 3 0 Laminin Domain II TMEM247 PF15444.6 KOO34276.1 - 0.019 15.0 1.0 0.021 14.9 1.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 247 BST2 PF16716.5 KOO34276.1 - 0.058 14.0 4.7 0.085 13.4 4.2 1.5 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 DUF4200 PF13863.6 KOO34276.1 - 0.16 12.3 8.6 0.21 12.0 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) GST_N_3 PF13417.6 KOO34277.1 - 1.3e-14 54.3 0.0 2.5e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KOO34277.1 - 1.1e-09 38.5 0.0 3.5e-09 36.9 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOO34277.1 - 1.2e-09 38.3 0.0 2.2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOO34277.1 - 5.7e-06 26.3 0.1 1.1e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 KOO34277.1 - 0.00036 21.1 0.1 0.00062 20.3 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOO34277.1 - 0.00048 20.3 0.1 0.0009 19.4 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOO34277.1 - 0.073 13.3 0.0 0.23 11.7 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KOO34277.1 - 0.12 13.1 0.0 0.29 11.9 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain PHD PF00628.29 KOO34278.1 - 1.1e-07 31.6 2.7 2.7e-07 30.3 1.4 2.3 2 1 0 2 2 2 1 PHD-finger Agenet PF05641.12 KOO34278.1 - 0.044 14.3 0.3 7.1 7.2 0.1 2.8 2 0 0 2 2 2 0 Agenet domain Pex24p PF06398.11 KOO34280.1 - 0.067 12.2 3.0 0.083 11.9 3.0 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Ank_2 PF12796.7 KOO34281.1 - 1.2e-07 32.2 0.1 0.00011 22.7 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO34281.1 - 9e-06 25.7 0.5 0.2 12.3 0.0 4.4 4 0 0 4 4 4 1 Ankyrin repeat PfkB PF00294.24 KOO34281.1 - 6.6e-05 22.4 0.1 0.00012 21.5 0.1 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Ank_4 PF13637.6 KOO34281.1 - 0.00034 21.1 2.3 0.15 12.7 0.0 4.3 4 1 2 6 6 6 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO34281.1 - 0.00056 20.2 0.7 0.013 15.8 0.1 3.5 4 0 0 4 4 4 1 Ankyrin repeats (many copies) TIR_2 PF13676.6 KOO34281.1 - 0.0052 17.4 0.0 0.02 15.5 0.0 2.0 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 KOO34281.1 - 0.012 15.4 0.0 0.034 14.0 0.0 1.6 2 0 0 2 2 2 0 TIR domain Ank PF00023.30 KOO34281.1 - 0.023 15.1 2.5 4.8 7.8 0.1 4.6 5 0 0 5 5 5 0 Ankyrin repeat DUF1863 PF08937.11 KOO34281.1 - 0.025 14.9 0.0 0.054 13.8 0.0 1.6 1 0 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) His_Phos_1 PF00300.22 KOO34282.1 - 0.028 14.1 0.1 0.13 12.0 0.1 2.0 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) Cupin_4 PF08007.12 KOO34283.1 - 4.9e-26 91.9 0.0 2.2e-25 89.8 0.0 1.9 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 KOO34283.1 - 0.0033 17.2 0.0 0.011 15.5 0.0 1.8 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 KOO34283.1 - 0.035 13.8 0.0 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 Cupin domain Cupin_1 PF00190.22 KOO34283.1 - 0.071 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Cupin JmjC PF02373.22 KOO34283.1 - 0.16 12.4 0.0 2.8 8.4 0.0 2.3 2 0 0 2 2 2 0 JmjC domain, hydroxylase LRR_6 PF13516.6 KOO34284.1 - 2.3e-39 130.1 13.1 1.4e-06 27.9 0.0 8.2 8 0 0 8 8 8 7 Leucine Rich repeat LRR_4 PF12799.7 KOO34284.1 - 1.3e-05 25.5 0.5 2.4 8.7 0.0 5.6 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO34284.1 - 1.4e-05 25.0 0.0 13 6.8 0.0 6.1 7 1 0 7 7 7 1 Leucine Rich Repeat SpoU_sub_bind PF08032.12 KOO34284.1 - 0.026 14.8 3.2 1.7 9.0 0.1 3.9 3 1 0 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding YycC PF14174.6 KOO34284.1 - 0.028 14.2 0.0 92 3.0 0.0 4.9 7 0 0 7 7 7 0 YycC-like protein HTH_3 PF01381.22 KOO34284.1 - 0.036 14.1 0.9 6 7.0 0.1 3.8 3 1 0 3 3 3 0 Helix-turn-helix CbiG_N PF11760.8 KOO34284.1 - 0.09 12.8 19.0 2.5 8.2 0.3 5.9 5 1 1 6 6 6 0 Cobalamin synthesis G N-terminal HOASN PF14515.6 KOO34284.1 - 0.094 13.1 10.6 13 6.2 0.2 5.3 2 1 2 5 5 5 0 Haem-oxygenase-associated N-terminal helices CTV_P13 PF06922.11 KOO34284.1 - 0.2 11.8 2.2 4.1 7.5 0.1 3.5 1 1 4 5 5 5 0 Citrus tristeza virus P13 protein CoatB PF10389.9 KOO34284.1 - 0.63 9.9 9.8 71 3.4 0.0 4.8 4 1 0 4 4 4 0 Bacteriophage coat protein B Homeodomain PF00046.29 KOO34285.1 - 2.6e-08 33.6 0.2 3.2e-08 33.3 0.2 1.2 1 0 0 1 1 1 1 Homeodomain A_deaminase PF00962.22 KOO34286.1 - 5.2e-108 361.2 0.1 7.6e-108 360.7 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase RIX1 PF08167.12 KOO34287.1 - 6.2e-13 48.9 0.1 8.1e-13 48.5 0.1 1.1 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis FdhE PF04216.12 KOO34287.1 - 0.019 14.9 2.3 0.026 14.4 2.3 1.2 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation HEAT PF02985.22 KOO34287.1 - 0.022 15.0 3.6 1.2 9.6 0.6 2.9 2 0 0 2 2 2 0 HEAT repeat Mito_carr PF00153.27 KOO34288.1 - 6.6e-36 122.1 4.0 4.8e-15 55.3 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PARP PF00644.20 KOO34289.1 - 6.2e-12 45.5 0.0 3.1e-11 43.2 0.0 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Sigma_reg_N PF13800.6 KOO34290.1 - 0.053 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Borrelia_P83 PF05262.11 KOO34291.1 - 0.042 12.4 8.4 0.057 11.9 8.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Golgin_A5 PF09787.9 KOO34291.1 - 0.12 11.9 13.8 0.19 11.2 13.8 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 SRP-alpha_N PF04086.13 KOO34291.1 - 0.69 9.8 15.4 1.1 9.1 15.4 1.5 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Sec34 PF04136.15 KOO34291.1 - 2.4 8.0 5.3 1.9 8.3 1.8 2.1 1 1 1 2 2 2 0 Sec34-like family AAA_13 PF13166.6 KOO34291.1 - 6.1 5.3 10.2 8.9 4.8 10.2 1.1 1 0 0 1 1 1 0 AAA domain Fez1 PF06818.15 KOO34291.1 - 7.6 6.9 16.9 14 6.1 16.9 1.5 1 0 0 1 1 1 0 Fez1 EF-hand_1 PF00036.32 KOO34292.1 - 2.1e-41 136.4 0.0 2.2e-06 26.8 0.0 6.4 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO34292.1 - 1.6e-39 134.2 0.4 2.5e-10 40.6 0.0 4.3 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO34292.1 - 1.1e-38 127.8 0.1 6.5e-05 22.5 0.0 6.8 6 1 1 7 7 7 6 EF-hand domain EF-hand_8 PF13833.6 KOO34292.1 - 6.3e-29 99.6 2.1 4.8e-09 35.9 0.0 5.4 4 3 3 7 7 7 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO34292.1 - 1.7e-27 93.7 0.3 7.2e-05 22.1 0.0 6.3 6 0 0 6 6 6 6 EF hand EF-hand_11 PF08976.11 KOO34292.1 - 3e-07 31.3 0.0 0.079 13.8 0.0 3.4 3 1 0 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO34292.1 - 5.6e-05 23.4 0.0 0.85 10.0 0.0 3.3 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO34292.1 - 0.00083 19.3 0.6 11 6.1 0.0 4.5 3 3 2 5 5 5 1 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.10 KOO34292.1 - 0.18 11.9 0.2 94 3.2 0.0 3.7 4 0 0 4 4 4 0 Ca2+ insensitive EF hand Tape_meas_lam_C PF09718.10 KOO34292.1 - 0.3 11.3 3.1 1.7 8.9 0.1 2.8 3 0 0 3 3 3 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Pkinase PF00069.25 KOO34293.1 - 4.5e-54 183.6 0.0 5.2e-53 180.1 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34293.1 - 1e-25 90.5 0.0 1.6e-24 86.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO34293.1 - 6.6e-08 32.2 0.1 0.0007 19.0 0.0 3.1 3 0 0 3 3 3 2 Kinase-like NIT PF08376.10 KOO34293.1 - 6e-06 26.9 0.2 1.1e-05 26.1 0.2 1.4 1 0 0 1 1 1 1 Nitrate and nitrite sensing Pkinase_fungal PF17667.1 KOO34293.1 - 5.6e-05 22.1 0.0 8.2e-05 21.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO34293.1 - 0.051 13.5 6.1 0.19 11.6 0.2 3.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF4326 PF14216.6 KOO34294.1 - 2.9e-12 47.1 0.0 6e-11 42.9 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4326) Kinesin PF00225.23 KOO34295.1 - 1.7e-13 50.2 0.0 8e-13 48.0 0.0 1.8 1 1 1 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOO34295.1 - 2.5e-05 24.2 0.0 3.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding EF-hand_6 PF13405.6 KOO34295.1 - 0.00014 21.5 0.0 0.0024 17.7 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 KOO34295.1 - 0.00019 21.2 0.0 0.00042 20.1 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 KOO34295.1 - 0.00049 20.5 0.0 0.019 15.4 0.0 2.3 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO34295.1 - 0.0029 17.0 0.0 0.028 13.9 0.0 2.5 3 0 0 3 3 3 1 EF hand CEP44 PF15007.6 KOO34297.1 - 0.031 14.4 0.1 0.4 10.8 0.0 2.3 2 0 0 2 2 2 0 Centrosomal spindle body, CEP44 DMSP_lyase PF16867.5 KOO34297.1 - 0.77 9.4 2.9 8 6.1 0.8 2.5 2 0 0 2 2 2 0 Dimethlysulfonioproprionate lyase eIF-5a PF01287.20 KOO34298.1 - 2.1e-10 40.5 0.2 3.5e-10 39.8 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 KOO34298.1 - 0.019 15.0 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Methyltransf_21 PF05050.12 KOO34299.1 - 0.00066 19.8 0.0 0.001 19.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain TehB PF03848.14 KOO34299.1 - 0.016 14.6 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_23 PF13489.6 KOO34299.1 - 0.14 11.9 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TAT_signal PF10518.9 KOO34300.1 - 5.3 7.1 10.3 0.08 12.8 2.7 1.9 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence HMG_box PF00505.19 KOO34301.1 - 1.1e-08 35.4 0.3 3.6e-08 33.7 0.3 1.8 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO34301.1 - 6.2e-05 23.5 1.5 0.00019 21.9 1.5 1.8 1 1 0 1 1 1 1 HMG-box domain Inhibitor_I29 PF08246.12 KOO34302.1 - 0.001 19.5 0.1 0.0017 18.8 0.1 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) E1_DerP2_DerF2 PF02221.15 KOO34302.1 - 0.18 12.3 0.0 0.26 11.7 0.0 1.2 1 0 0 1 1 1 0 ML domain Ribosomal_60s PF00428.19 KOO34302.1 - 8.3 7.1 11.0 0.61 10.7 5.9 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein SKG6 PF08693.10 KOO34303.1 - 0.16 11.4 4.3 0.13 11.7 1.6 2.2 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Ank_2 PF12796.7 KOO34304.1 - 2.2e-27 95.5 22.6 1.4e-10 41.6 0.8 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34304.1 - 2.8e-22 78.8 8.3 2.9e-07 30.9 0.0 5.0 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO34304.1 - 7.5e-15 54.6 20.2 0.00016 21.9 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 KOO34304.1 - 2.4e-14 53.2 13.5 2.5e-06 27.6 0.1 6.0 3 1 3 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34304.1 - 1.9e-12 46.2 9.9 0.16 12.7 0.1 6.3 6 0 0 6 6 6 4 Ankyrin repeat Crust_neuro_H PF03858.13 KOO34304.1 - 0.015 16.1 6.4 0.37 11.6 0.1 4.3 3 1 1 4 4 4 0 Crustacean neurohormone H OB_NTP_bind PF07717.16 KOO34305.1 - 5.6e-18 65.1 0.0 1.2e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOO34305.1 - 1.1e-12 48.3 0.0 2.1e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 KOO34305.1 - 1.2e-12 48.0 0.0 3.6e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 KOO34305.1 - 4.5e-05 23.3 0.1 7.6e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 KOO34305.1 - 0.00097 19.5 0.4 0.0023 18.3 0.4 1.6 1 0 0 1 1 1 1 AAA domain zf-met PF12874.7 KOO34305.1 - 0.0012 19.1 8.7 0.13 12.7 1.0 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type AAA_30 PF13604.6 KOO34305.1 - 0.0084 15.8 0.2 0.026 14.2 0.2 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOO34305.1 - 0.01 16.1 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KOO34305.1 - 0.011 15.0 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 KaiC zf-C2H2_jaz PF12171.8 KOO34305.1 - 0.036 14.4 8.6 0.19 12.0 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding T2SSE PF00437.20 KOO34305.1 - 0.1 11.6 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein zf_UBZ PF18439.1 KOO34305.1 - 4.7 6.9 5.3 22 4.8 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger MgtE PF01769.16 KOO34306.1 - 6.8e-17 62.0 6.7 1.2e-16 61.2 6.7 1.4 1 0 0 1 1 1 1 Divalent cation transporter Dpy-30 PF05186.13 KOO34306.1 - 0.0046 16.6 0.0 0.0098 15.6 0.0 1.6 1 0 0 1 1 1 1 Dpy-30 motif FKBP_C PF00254.28 KOO34307.1 - 1e-23 83.5 0.1 1.1e-23 83.3 0.1 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 PF00036.32 KOO34308.1 - 2.6e-22 76.6 10.5 3.4e-06 26.2 0.0 5.3 4 1 1 5 5 5 5 EF hand EF-hand_7 PF13499.6 KOO34308.1 - 1.5e-21 76.6 8.6 3e-09 37.2 1.4 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO34308.1 - 3.6e-21 73.2 10.3 2.1e-08 33.5 0.0 5.4 4 1 1 5 5 5 5 EF-hand domain EF-hand_5 PF13202.6 KOO34308.1 - 1.2e-11 43.5 9.4 0.00011 21.6 0.0 5.2 4 1 1 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO34308.1 - 4.5e-07 29.6 16.0 0.0077 16.1 0.9 5.1 3 3 3 6 6 6 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO34308.1 - 2.7e-06 27.7 1.0 0.0039 17.5 0.4 3.2 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO34308.1 - 0.00014 21.7 5.1 0.2 11.6 0.3 3.1 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO34308.1 - 0.016 15.1 0.6 17 5.4 0.0 3.5 4 0 0 4 4 4 0 EF hand EF-hand_9 PF14658.6 KOO34308.1 - 0.12 12.8 1.9 12 6.4 0.0 3.1 2 1 0 2 2 2 0 EF-hand domain LRR_6 PF13516.6 KOO34309.1 - 1.1e-17 62.5 13.4 0.099 12.7 0.2 10.4 10 0 0 10 10 10 6 Leucine Rich repeat LRR_4 PF12799.7 KOO34309.1 - 1.9e-07 31.2 2.9 0.063 13.7 0.0 5.5 5 1 1 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO34309.1 - 7.3e-05 22.8 0.1 77 4.5 0.0 6.3 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO34309.1 - 0.0029 17.3 6.9 4.7 7.0 0.1 6.3 5 3 0 6 6 6 1 Leucine rich repeat RNase_HII PF01351.18 KOO34310.1 - 5.2e-30 104.8 0.0 9.4e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease HII Titin_Z PF09042.11 KOO34310.1 - 0.44 10.5 5.2 1.5 8.8 5.2 1.9 1 0 0 1 1 1 0 Titin Z ZZ PF00569.17 KOO34311.1 - 0.00049 19.9 0.0 0.0011 18.8 0.0 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type Pro_isomerase PF00160.21 KOO34312.1 - 9.5e-29 100.7 0.0 1.5e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_A22B PF04258.13 KOO34313.1 - 1.7e-44 152.5 7.9 1.4e-43 149.5 7.9 1.9 1 1 0 1 1 1 1 Signal peptide peptidase PA PF02225.22 KOO34313.1 - 0.0036 17.3 0.7 0.0079 16.2 0.7 1.6 1 0 0 1 1 1 1 PA domain LRR_5 PF13306.6 KOO34314.1 - 1.4e-71 238.5 0.1 8.5e-38 129.2 0.0 2.0 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO34314.1 - 1.1e-13 50.7 0.0 0.0019 17.9 0.0 5.3 2 2 4 6 6 6 4 Leucine rich repeat He_PIG PF05345.12 KOO34314.1 - 0.0051 17.0 9.0 42 4.4 0.1 6.9 8 0 0 8 8 8 1 Putative Ig domain DDE_Tnp_1_6 PF13751.6 KOO34315.1 - 0.0034 17.6 5.0 3.9 7.7 0.1 3.8 1 1 2 4 4 4 3 Transposase DDE domain Phage-tail_3 PF13550.6 KOO34315.1 - 0.029 14.2 1.2 1.9 8.3 0.1 3.0 2 1 1 3 3 3 0 Putative phage tail protein Pkinase PF00069.25 KOO34316.1 - 2.4e-43 148.4 0.0 2e-38 132.3 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34316.1 - 4.7e-19 68.7 0.0 6.4e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO34316.1 - 0.054 13.4 0.0 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1381 PF07129.11 KOO34316.1 - 7 6.6 6.4 26 4.7 0.3 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1381) FKBP_C PF00254.28 KOO34319.1 - 1.8e-19 69.8 0.0 2.9e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Zea_mays_MuDR PF05928.11 KOO34320.1 - 0.93 9.1 5.8 1.2 8.8 5.8 1.3 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) RRM_1 PF00076.22 KOO34321.1 - 1.8e-12 46.9 0.0 3.4e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TruB_C_2 PF16198.5 KOO34322.1 - 0.39 10.9 5.6 0.33 11.1 1.5 2.4 2 0 0 2 2 2 0 tRNA pseudouridylate synthase B C-terminal domain Asp4 PF16996.5 KOO34323.1 - 0.16 11.8 0.1 0.24 11.2 0.1 1.3 1 0 0 1 1 1 0 Accessory secretory protein Sec Asp4 Metallophos_2 PF12850.7 KOO34324.1 - 2.1e-09 37.8 0.0 3.9e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 KOO34324.1 - 4.6e-08 33.8 0.0 1.6e-07 32.0 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase REV PF00424.18 KOO34324.1 - 0.071 13.1 0.5 0.34 11.0 0.3 2.2 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Tudor-knot PF11717.8 KOO34325.1 - 1.9e-07 30.9 0.3 2.2e-06 27.4 0.3 2.3 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain BRCT_3 PF18428.1 KOO34325.1 - 1.3e-05 25.2 0.0 2.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Agenet PF05641.12 KOO34325.1 - 0.003 18.0 0.6 0.74 10.3 0.0 3.0 2 1 1 3 3 3 2 Agenet domain BRCT_2 PF16589.5 KOO34325.1 - 0.027 14.9 0.0 0.3 11.5 0.0 2.1 1 1 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain MBT PF02820.18 KOO34325.1 - 0.12 12.8 0.1 0.78 10.1 0.1 2.2 1 1 0 1 1 1 0 mbt repeat PTCB-BRCT PF12738.7 KOO34325.1 - 0.17 11.8 0.0 1.1 9.3 0.0 2.2 2 1 1 3 3 3 0 twin BRCT domain HA PF03457.14 KOO34326.1 - 3.2e-37 126.7 0.4 1.3e-11 44.7 0.0 3.4 3 0 0 3 3 3 3 Helicase associated domain DHHC PF01529.20 KOO34327.1 - 9.9e-15 54.8 11.3 9.9e-15 54.8 11.3 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase CobD_Cbib PF03186.13 KOO34327.1 - 0.21 10.7 2.7 0.48 9.6 0.1 2.0 2 0 0 2 2 2 0 CobD/Cbib protein MHYT PF03707.16 KOO34327.1 - 7.4 6.8 8.1 19 5.5 1.0 2.5 2 0 0 2 2 2 0 Bacterial signalling protein N terminal repeat DUF2828 PF11443.8 KOO34328.1 - 3e-75 253.6 0.0 5.7e-52 176.7 0.0 3.8 2 2 1 3 3 3 3 Domain of unknown function (DUF2828) VWA_CoxE PF05762.14 KOO34328.1 - 4.5e-07 29.5 0.0 8.8e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_2 PF13519.6 KOO34328.1 - 0.00044 20.9 0.0 0.00094 19.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 KOO34328.1 - 0.085 12.8 0.0 0.4 10.6 0.0 2.2 2 0 0 2 2 2 0 von Willebrand factor type A domain Glyco_hydro_30 PF02055.16 KOO34329.1 - 7.7e-46 156.7 0.8 7.6e-26 90.9 0.1 3.0 3 0 0 3 3 3 2 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 KOO34329.1 - 3.6e-05 23.1 0.0 0.001 18.4 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 59 Glyco_hydro_30 PF02055.16 KOO34330.1 - 1.9e-15 56.7 0.1 6.8e-15 54.9 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 30 TIM-barrel domain TPR_10 PF13374.6 KOO34331.1 - 2.1e-43 145.0 11.4 2.1e-09 37.0 0.1 6.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_12 PF13424.6 KOO34331.1 - 8.1e-42 141.4 17.9 3.7e-12 46.3 0.1 5.2 1 1 3 5 5 5 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO34331.1 - 6.6e-16 58.6 5.8 2.1e-11 43.8 0.5 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_2 PF07719.17 KOO34331.1 - 1.4e-11 43.5 6.1 0.23 11.7 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO34331.1 - 6.2e-11 41.5 7.1 0.014 15.3 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO34331.1 - 8.6e-09 34.9 0.2 0.098 12.9 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34331.1 - 1.4e-08 34.2 1.6 0.9 9.5 0.0 6.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO34331.1 - 2e-08 34.4 15.1 1.2 10.1 0.3 6.5 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO34331.1 - 1.1e-07 31.7 7.8 1.7 9.5 0.0 6.2 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO34331.1 - 1.5e-07 32.0 20.2 0.0029 18.2 0.4 5.9 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO34331.1 - 6.6e-05 23.4 11.5 0.03 14.8 0.5 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO34331.1 - 0.0021 18.3 0.3 0.37 11.1 0.0 4.0 4 0 0 4 4 4 1 Osmosensory transporter coiled coil TPR_17 PF13431.6 KOO34331.1 - 0.0027 18.0 2.9 0.94 10.0 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat HisKA_3 PF07730.13 KOO34331.1 - 0.022 15.2 6.2 1.4 9.4 0.0 4.1 4 2 0 4 4 4 0 Histidine kinase TPR_3 PF07720.12 KOO34331.1 - 0.053 13.5 0.4 0.78 9.8 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat DNA_ligase_A_N PF04675.14 KOO34331.1 - 0.098 13.0 0.1 0.57 10.5 0.0 2.1 2 1 0 2 2 2 0 DNA ligase N terminus LRR_4 PF12799.7 KOO34333.1 - 1.4e-18 66.6 4.2 5.7e-08 32.9 2.7 3.9 3 1 1 4 4 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOO34333.1 - 1.2e-10 41.2 0.0 5.3e-07 29.3 0.0 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KOO34333.1 - 1.5e-09 37.5 7.5 4e-05 23.3 3.1 3.4 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 KOO34333.1 - 0.0075 16.7 4.9 8.7 7.3 0.2 4.4 4 0 0 4 4 4 1 Leucine Rich Repeat Mto2_bdg PF12808.7 KOO34333.1 - 0.025 14.9 0.7 0.025 14.9 0.7 2.6 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region LRR_6 PF13516.6 KOO34333.1 - 0.11 12.6 10.5 31 5.0 0.0 5.1 6 0 0 6 6 5 0 Leucine Rich repeat ALIX_LYPXL_bnd PF13949.6 KOO34333.1 - 0.19 11.0 3.8 0.33 10.2 3.8 1.4 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV CENP-F_leu_zip PF10473.9 KOO34333.1 - 0.64 10.0 7.7 6.4 6.8 0.1 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.12 KOO34333.1 - 0.89 10.0 11.1 0.14 12.6 5.8 2.5 2 0 0 2 2 2 0 Cell division protein ZapB YabA PF06156.13 KOO34333.1 - 1.9 9.2 6.0 3 8.5 3.9 2.3 2 1 0 2 2 2 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 KOO34333.1 - 3.3 7.9 8.5 3.4 7.9 3.5 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding HALZ PF02183.18 KOO34333.1 - 3.5 7.9 5.9 6.6 7.1 0.6 2.8 1 1 1 2 2 2 0 Homeobox associated leucine zipper PRKG1_interact PF15898.5 KOO34333.1 - 4.2 8.3 7.8 8.6 7.3 5.7 2.4 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain NYD-SP28_assoc PF14775.6 KOO34333.1 - 4.5 7.4 5.4 24 5.1 0.2 2.8 3 0 0 3 3 3 0 Sperm tail C-terminal domain bZIP_2 PF07716.15 KOO34333.1 - 5.1 7.3 9.0 8.6 6.5 1.6 2.7 1 1 1 2 2 2 0 Basic region leucine zipper EF-hand_5 PF13202.6 KOO34334.1 - 1.2e-05 24.6 0.0 2.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO34334.1 - 0.0043 16.5 0.0 0.011 15.2 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO34334.1 - 0.031 14.2 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.6 KOO34334.1 - 0.082 12.8 0.1 0.68 9.8 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair VIR_N PF15912.5 KOO34336.1 - 0.07 12.7 1.0 0.1 12.1 1.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Myb_DNA-binding PF00249.31 KOO34337.1 - 9.4e-32 109.0 4.6 9.7e-16 57.7 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO34337.1 - 6.2e-24 84.0 1.7 1.1e-14 54.4 0.1 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Sigma70_r4_2 PF08281.12 KOO34337.1 - 0.0014 18.3 0.0 0.0027 17.3 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Myb_DNA-bind_7 PF15963.5 KOO34337.1 - 0.0025 17.6 0.1 0.083 12.8 0.0 2.2 1 1 1 2 2 2 1 Myb DNA-binding like SLIDE PF09111.10 KOO34337.1 - 0.017 15.2 0.0 2 8.5 0.0 2.3 2 0 0 2 2 2 0 SLIDE SANT_DAMP1_like PF16282.5 KOO34337.1 - 0.047 13.9 0.4 0.32 11.2 0.1 2.0 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Peptidase_M10 PF00413.24 KOO34339.1 - 2.6e-07 30.6 0.0 0.00017 21.5 0.0 2.2 2 0 0 2 2 2 2 Matrixin Reprolysin_5 PF13688.6 KOO34339.1 - 0.033 14.3 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 EF-hand_5 PF13202.6 KOO34339.1 - 0.046 13.2 0.0 0.083 12.4 0.0 1.3 1 0 0 1 1 1 0 EF hand Reprolysin_3 PF13582.6 KOO34339.1 - 0.049 14.1 0.0 0.098 13.2 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 KOO34339.1 - 0.065 12.4 0.2 0.11 11.7 0.2 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_4 PF13583.6 KOO34339.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Arm PF00514.23 KOO34340.1 - 3.1e-09 36.6 12.4 0.027 14.5 0.2 7.4 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat Hist_deacetyl PF00850.19 KOO34341.1 - 1e-51 176.3 0.1 1.5e-51 175.7 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Ank_2 PF12796.7 KOO34341.1 - 1.4e-16 60.9 5.8 5e-08 33.4 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO34341.1 - 4.8e-10 39.5 5.0 0.0015 18.8 0.1 4.5 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO34341.1 - 7e-10 38.9 16.8 0.00014 22.2 0.1 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 KOO34341.1 - 1.2e-08 35.3 3.4 0.0025 18.4 0.2 5.0 3 2 3 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34341.1 - 1.9e-05 24.7 6.5 0.048 14.2 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeat HMG_box PF00505.19 KOO34342.1 - 2.6e-21 75.8 16.6 1.5e-15 57.4 0.5 3.0 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO34342.1 - 1.8e-17 63.7 18.5 2.1e-11 44.3 0.7 3.1 3 0 0 3 3 3 2 HMG-box domain Ribosomal_L27A PF00828.19 KOO34343.1 - 1.8e-11 44.8 0.0 2.8e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A ADH_zinc_N PF00107.26 KOO34345.1 - 2.1e-08 34.2 0.0 3e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOO34345.1 - 2.5e-07 31.8 0.0 3.9e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TRAPP PF04051.16 KOO34346.1 - 2e-39 134.6 0.0 2.4e-39 134.4 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Phosphoesterase PF04185.14 KOO34347.1 - 2.1e-50 171.9 0.1 4e-50 171.0 0.1 1.5 1 1 0 1 1 1 1 Phosphoesterase family C1ORF64 PF15547.6 KOO34347.1 - 0.072 13.6 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Steroid receptor-associated and regulated protein Cupin_8 PF13621.6 KOO34348.1 - 1.8e-19 70.4 0.0 2.5e-12 47.0 0.2 2.1 1 1 0 2 2 2 2 Cupin-like domain Folate_rec PF03024.14 KOO34349.1 - 6.8e-22 78.2 17.9 1.4e-21 77.1 17.9 1.4 1 1 0 1 1 1 1 Folate receptor family SKG6 PF08693.10 KOO34349.1 - 8.1 6.0 7.8 16 5.0 7.8 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Cupin_8 PF13621.6 KOO34350.1 - 0.0017 18.2 0.0 0.0031 17.3 0.0 1.4 2 0 0 2 2 2 1 Cupin-like domain JmjC PF02373.22 KOO34350.1 - 0.0021 18.5 0.0 0.04 14.3 0.0 2.1 1 1 0 1 1 1 1 JmjC domain, hydroxylase DUF3304 PF11745.8 KOO34353.1 - 0.058 13.8 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3304) 2OG-FeII_Oxy_2 PF13532.6 KOO34354.1 - 1.7e-14 54.4 0.1 1.9e-13 51.1 0.1 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily AF-4 PF05110.13 KOO34354.1 - 0.059 11.5 1.4 0.066 11.3 1.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein 2OG-FeII_Oxy PF03171.20 KOO34354.1 - 0.14 12.7 0.1 0.24 11.9 0.1 1.4 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Glyco_hydro_92 PF07971.12 KOO34355.1 - 1.2e-71 242.0 0.0 5.2e-63 213.6 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 92 DUF4855 PF16147.5 KOO34356.1 - 0.25 10.4 0.1 0.3 10.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4855) Arm PF00514.23 KOO34357.1 - 0.00041 20.3 0.4 1.1 9.5 0.3 2.9 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Aldo_ket_red PF00248.21 KOO34358.1 - 1.1e-16 60.9 0.0 1.2e-16 60.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TTL PF03133.15 KOO34359.1 - 3.8e-16 59.1 0.3 3.6e-15 55.9 0.9 1.8 1 1 1 2 2 2 2 Tubulin-tyrosine ligase family F-box-like PF12937.7 KOO34360.1 - 0.0029 17.5 0.1 0.0029 17.5 0.1 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 KOO34360.1 - 0.039 13.8 1.7 0.055 13.4 0.1 2.2 2 0 0 2 2 2 0 F-box domain PH PF00169.29 KOO34361.1 - 0.0029 18.1 0.0 0.0057 17.1 0.0 1.5 1 0 0 1 1 1 1 PH domain Hexapep PF00132.24 KOO34361.1 - 0.23 11.3 0.2 2 8.3 0.1 2.2 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) HECA PF15353.6 KOO34362.1 - 8e-10 38.9 4.8 8.5e-08 32.4 4.8 2.7 1 1 0 1 1 1 1 Headcase protein family homologue RRM_1 PF00076.22 KOO34362.1 - 1.4e-07 31.2 0.1 5e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Jiraiya PF15038.6 KOO34363.1 - 0.0024 17.3 0.3 0.0041 16.6 0.3 1.3 1 0 0 1 1 1 1 Jiraiya PDZ_6 PF17820.1 KOO34368.1 - 4.2e-11 42.5 0.0 1.4e-05 24.9 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 KOO34368.1 - 7.5e-10 39.0 0.0 0.00064 20.0 0.0 2.3 2 0 0 2 2 2 2 PDZ domain M16C_assoc PF08367.11 KOO34368.1 - 1.9 7.5 5.9 0.56 9.3 3.1 1.4 2 0 0 2 2 2 0 Peptidase M16C associated Spc7 PF08317.11 KOO34370.1 - 0.015 14.2 0.2 0.015 14.2 0.2 4.9 1 1 3 5 5 5 0 Spc7 kinetochore protein Vps51 PF08700.11 KOO34370.1 - 0.022 14.8 1.0 12 6.1 0.0 4.8 4 0 0 4 4 4 0 Vps51/Vps67 DUF1664 PF07889.12 KOO34370.1 - 0.45 10.6 12.6 45 4.1 0.5 5.5 2 2 4 7 7 7 0 Protein of unknown function (DUF1664) DELLA PF12041.8 KOO34370.1 - 0.52 10.2 3.4 18 5.3 0.0 3.8 3 0 0 3 3 3 0 Transcriptional regulator DELLA protein N terminal Baculo_PEP_C PF04513.12 KOO34370.1 - 2.5 8.1 15.4 2.4 8.2 1.5 4.7 2 1 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 KOO34370.1 - 2.7 8.2 10.2 1.7 8.9 1.0 4.1 2 1 1 4 4 4 0 Fibrinogen alpha/beta chain family Arm PF00514.23 KOO34371.1 - 1.1e-09 38.0 6.8 0.097 12.8 0.1 6.5 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KOO34371.1 - 0.039 13.5 0.0 1.3 8.6 0.1 2.6 2 0 0 2 2 2 0 Atypical Arm repeat HEAT PF02985.22 KOO34371.1 - 4 7.9 6.3 8.3 7.0 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat Myosin_head PF00063.21 KOO34372.1 - 2.2e-182 607.8 0.0 5e-182 606.7 0.0 1.6 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_18 PF13238.6 KOO34372.1 - 0.012 16.2 0.0 0.012 16.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 KOO34372.1 - 0.019 15.3 0.0 0.019 15.3 0.0 3.6 4 1 0 4 4 4 0 AAA domain AAA_16 PF13191.6 KOO34372.1 - 0.028 14.8 0.0 0.028 14.8 0.0 6.3 4 1 0 4 4 4 0 AAA ATPase domain RNA_helicase PF00910.22 KOO34372.1 - 0.14 12.5 0.0 0.49 10.8 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.6 KOO34372.1 - 0.35 11.2 0.0 0.35 11.2 0.0 3.6 3 1 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 KOO34372.1 - 0.47 10.3 2.2 0.75 9.7 0.1 2.3 2 0 0 2 2 2 0 NTPase DUF5600 PF18150.1 KOO34373.1 - 4.6e-40 136.5 0.3 8.2e-40 135.7 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 KOO34373.1 - 9.5e-21 73.7 0.0 2.7e-20 72.2 0.0 1.8 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Dynamin_N PF00350.23 KOO34373.1 - 1.6e-15 57.6 0.0 2.5e-13 50.4 0.0 2.3 1 1 0 1 1 1 1 Dynamin family EHD_N PF16880.5 KOO34373.1 - 9.9e-15 54.1 0.0 1.9e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.23 KOO34373.1 - 2.4e-10 40.5 0.0 4.4e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 KOO34373.1 - 0.0002 21.5 0.0 0.36 11.0 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KOO34373.1 - 0.00066 19.1 0.0 0.0031 16.9 0.0 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region EF-hand_1 PF00036.32 KOO34373.1 - 0.0023 17.4 0.0 0.0074 15.8 0.0 2.0 1 0 0 1 1 1 1 EF hand GTP_EFTU PF00009.27 KOO34373.1 - 0.0048 16.5 0.1 0.012 15.2 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EF-hand_6 PF13405.6 KOO34373.1 - 0.014 15.3 0.0 0.066 13.2 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain DEC-1_N PF04625.13 KOO34373.1 - 0.019 14.0 10.3 0.03 13.4 10.3 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region EF-hand_7 PF13499.6 KOO34373.1 - 0.022 15.2 0.1 0.18 12.3 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair AAA_24 PF13479.6 KOO34373.1 - 0.026 14.2 0.1 11 5.7 0.1 2.8 2 1 0 2 2 2 0 AAA domain EF-hand_8 PF13833.6 KOO34373.1 - 0.035 13.9 0.0 5.6 6.9 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair RsgA_GTPase PF03193.16 KOO34373.1 - 0.038 13.9 0.1 17 5.3 0.0 3.0 2 1 1 3 3 3 0 RsgA GTPase CAP_N PF01213.19 KOO34373.1 - 0.08 12.4 8.5 0.16 11.4 8.5 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Ras PF00071.22 KOO34373.1 - 0.13 11.9 0.1 8.1 6.0 0.0 2.3 2 0 0 2 2 2 0 Ras family AIG1 PF04548.16 KOO34373.1 - 0.13 11.6 0.0 0.79 9.0 0.0 2.0 2 0 0 2 2 2 0 AIG1 family Focal_AT PF03623.13 KOO34373.1 - 0.14 12.1 0.1 0.51 10.3 0.0 1.9 2 0 0 2 2 2 0 Focal adhesion targeting region AAA_16 PF13191.6 KOO34373.1 - 0.18 12.2 0.2 1.3 9.4 0.2 2.2 1 1 0 1 1 1 0 AAA ATPase domain Ank_2 PF12796.7 KOO34374.1 - 1.8e-07 31.6 0.2 7.7e-06 26.4 0.2 2.6 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34374.1 - 5.7e-07 30.0 0.1 0.0077 16.8 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO34374.1 - 7.8e-07 29.3 0.4 2.8e-06 27.5 0.2 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO34374.1 - 4.1e-05 23.8 0.1 0.022 15.2 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 KOO34374.1 - 0.015 15.8 0.0 55 4.8 0.0 4.3 4 1 0 4 4 4 0 Ankyrin repeat FKBP_C PF00254.28 KOO34375.1 - 2.5e-29 101.4 0.0 5.7e-29 100.3 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 KOO34375.1 - 7.9e-08 31.8 6.6 0.0066 16.5 0.0 5.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34375.1 - 4.9e-06 26.1 7.0 0.00041 20.0 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO34375.1 - 0.00028 21.0 0.0 0.00028 21.0 0.0 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO34375.1 - 0.033 14.4 3.0 0.087 13.1 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat SCVP PF17619.2 KOO34375.1 - 0.1 13.4 0.0 0.28 12.1 0.0 1.7 1 0 0 1 1 1 0 Secreted clade V proteins Porin_2 PF02530.14 KOO34375.1 - 3.1 7.0 9.8 5 6.3 9.8 1.2 1 0 0 1 1 1 0 Porin subfamily Adap_comp_sub PF00928.21 KOO34376.1 - 5.3e-87 291.5 0.0 6.7e-87 291.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KOO34376.1 - 0.02 14.8 0.2 0.055 13.4 0.2 1.8 1 1 0 1 1 1 0 Clathrin adaptor complex small chain DUF3481 PF11980.8 KOO34377.1 - 0.054 13.2 0.2 0.63 9.8 0.0 2.5 2 0 0 2 2 2 0 C-terminal domain of neuropilin glycoprotein ubiquitin PF00240.23 KOO34378.1 - 1.1e-07 31.5 0.3 2.8e-07 30.2 0.3 1.6 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 KOO34378.1 - 2.7e-06 27.7 0.1 1.5e-05 25.4 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 KOO34378.1 - 0.046 13.6 0.2 0.22 11.4 0.2 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like RAWUL PF16207.5 KOO34378.1 - 0.071 13.8 0.0 0.093 13.4 0.0 1.2 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like Arm PF00514.23 KOO34379.1 - 9.1e-32 108.1 17.7 1.7e-06 27.8 0.1 6.3 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat TetR_C_34 PF17929.1 KOO34379.1 - 0.00021 21.4 2.5 2.5 8.2 0.2 4.0 2 1 3 5 5 5 2 Tetracyclin repressor-like, C-terminal domain Atx10homo_assoc PF09759.9 KOO34379.1 - 0.00047 20.1 0.1 2.5 8.2 0.0 3.7 2 1 2 4 4 4 2 Spinocerebellar ataxia type 10 protein domain LysM PF01476.20 KOO34379.1 - 0.0057 16.7 3.6 4.6 7.4 0.0 3.7 4 0 0 4 4 4 2 LysM domain Succ_CoA_lig PF13607.6 KOO34379.1 - 0.0093 15.8 16.2 1.2 9.0 0.4 4.3 1 1 3 4 4 4 3 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 KOO34379.1 - 0.26 11.8 12.0 30 5.1 0.1 4.2 1 1 3 4 4 4 0 CoA binding domain PPE PF00823.19 KOO34379.1 - 6.9 6.7 28.4 2.6 8.1 2.4 4.6 4 1 0 4 4 4 0 PPE family 2OG-FeII_Oxy_3 PF13640.6 KOO34380.1 - 4.6e-06 27.4 0.1 6.5e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HMG_box PF00505.19 KOO34381.1 - 3.4e-14 53.0 8.4 4.1e-08 33.5 0.4 4.5 4 1 1 5 5 5 2 HMG (high mobility group) box PWWP PF00855.17 KOO34381.1 - 4.4e-12 46.2 0.0 4.4e-12 46.2 0.0 3.6 3 1 1 4 4 4 1 PWWP domain HMG_box_2 PF09011.10 KOO34381.1 - 7.5e-06 26.4 16.0 0.0006 20.4 0.6 3.9 1 1 2 3 3 3 2 HMG-box domain DDT PF02791.17 KOO34381.1 - 1.4e-05 25.3 0.3 5e-05 23.5 0.3 2.0 1 0 0 1 1 1 1 DDT domain WSD PF15613.6 KOO34381.1 - 0.00017 22.0 3.6 0.00028 21.3 0.0 3.2 2 1 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif RNA_polI_A34 PF08208.11 KOO34381.1 - 2.4 8.2 17.2 0.92 9.6 3.4 2.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 2OG-FeII_Oxy_3 PF13640.6 KOO34382.1 - 0.00029 21.7 0.0 0.00085 20.2 0.0 1.9 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 KOO34382.1 - 0.0045 16.1 0.0 0.0071 15.5 0.0 1.2 1 0 0 1 1 1 1 Poxvirus C4/C10 protein Tli4_C PF18426.1 KOO34382.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Tle cognate immunity protein 4 C-terminal domain GDPD PF03009.17 KOO34384.1 - 0.01 15.6 0.0 0.02 14.7 0.0 1.6 1 1 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family rve PF00665.26 KOO34385.1 - 1.1e-06 28.8 0.0 2.9e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain UQ_con PF00179.26 KOO34386.1 - 1e-44 151.6 0.0 1.7e-44 150.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFD1 PF03152.14 KOO34386.1 - 7e-19 68.0 0.0 1.1e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 PDZ PF00595.24 KOO34386.1 - 3.7e-08 33.6 0.1 7.4e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 PDZ domain UBX PF00789.20 KOO34386.1 - 9.6e-08 32.1 0.0 2.4e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 UBX domain PDZ_6 PF17820.1 KOO34386.1 - 3.9e-06 26.6 0.0 1e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 PDZ domain RMI1_N PF08585.12 KOO34386.1 - 0.0023 17.7 0.9 0.0039 17.0 0.9 1.3 1 0 0 1 1 1 1 RecQ mediated genome instability protein PDZ_2 PF13180.6 KOO34386.1 - 0.034 14.5 0.1 0.072 13.4 0.1 1.5 1 0 0 1 1 1 0 PDZ domain Spc7 PF08317.11 KOO34386.1 - 8.5 5.2 14.4 13 4.5 14.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Borrelia_P83 PF05262.11 KOO34386.1 - 9.1 4.6 11.9 13 4.1 11.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein LRR_6 PF13516.6 KOO34387.1 - 5.7e-22 75.8 59.5 0.0049 16.8 0.2 18.9 22 0 0 22 22 22 8 Leucine Rich repeat LRR_4 PF12799.7 KOO34387.1 - 3.1e-09 37.0 15.8 0.34 11.4 0.1 10.9 12 3 0 12 12 12 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO34387.1 - 6.8e-08 32.0 0.5 1e+02 4.0 0.0 10.4 14 0 0 14 14 14 0 Leucine Rich Repeat SLT_L PF14718.6 KOO34387.1 - 0.011 15.8 0.1 1e+02 3.2 0.0 4.3 4 0 0 4 4 4 0 Soluble lytic murein transglycosylase L domain SpoU_sub_bind PF08032.12 KOO34387.1 - 0.047 14.0 3.6 73 3.7 0.0 5.5 6 0 0 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding Metal_CEHH PF14455.6 KOO34387.1 - 0.063 12.9 0.3 34 4.0 0.0 4.3 5 1 1 6 6 6 0 Predicted metal binding domain Peptidase_M23_N PF18421.1 KOO34387.1 - 0.14 12.1 0.4 51 3.9 0.1 4.1 4 0 0 4 4 4 0 Peptidase family M23 N-terminal domain TA_inhibitor PF17574.2 KOO34387.1 - 1.2 9.3 4.0 20 5.3 0.1 3.9 4 0 0 4 4 4 0 Inhibitor of toxin/antitoxin system (Gp4.5) Pkinase PF00069.25 KOO34388.1 - 2.5e-42 145.1 0.0 3.5e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34388.1 - 1.6e-37 129.2 0.0 2.2e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO34388.1 - 5.4e-05 22.2 0.0 7.9e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO34388.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 KOO34388.1 - 0.035 14.0 0.1 0.077 12.9 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO34388.1 - 0.17 11.2 0.1 0.27 10.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_topoisoIV PF00521.20 KOO34389.1 - 3.5e-41 141.5 0.0 4.9e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KOO34389.1 - 5.8e-13 49.2 0.0 1e-12 48.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM SAP PF02037.27 KOO34389.1 - 2.1e-12 46.5 0.1 4.2e-12 45.5 0.1 1.6 1 0 0 1 1 1 1 SAP domain HATPase_c PF02518.26 KOO34389.1 - 1.8e-10 41.3 0.0 3e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_gyraseB PF00204.25 KOO34389.1 - 1.7e-05 24.3 0.0 3.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.22 KOO34389.1 - 0.0015 18.7 0.0 0.0069 16.6 0.0 2.0 1 1 0 1 1 1 1 Toprim domain HeH PF12949.7 KOO34389.1 - 0.012 15.3 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 HeH/LEM domain Pkinase PF00069.25 KOO34390.1 - 4.4e-46 157.4 0.0 6.3e-46 156.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34390.1 - 2e-38 132.2 0.0 3.1e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Comm PF15957.5 KOO34390.1 - 0.11 12.8 0.1 0.3 11.4 0.1 1.7 1 0 0 1 1 1 0 Commissureless Ribosomal_S28e PF01200.18 KOO34391.1 - 2e-32 111.0 0.5 2.2e-32 110.9 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e WD40 PF00400.32 KOO34392.1 - 2.9e-17 62.7 12.6 0.00034 21.4 0.6 10.1 10 0 0 10 10 10 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO34392.1 - 1.4e-05 25.3 0.0 4 7.8 0.0 5.4 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 KOO34392.1 - 0.0079 16.0 2.2 0.018 14.8 0.0 2.4 3 0 0 3 3 3 1 Lipoprotein LpqB beta-propeller domain Fibrillarin PF01269.17 KOO34392.1 - 0.096 11.8 0.0 0.26 10.4 0.0 1.7 1 0 0 1 1 1 0 Fibrillarin Ge1_WD40 PF16529.5 KOO34392.1 - 0.2 10.6 0.3 0.91 8.4 0.0 2.3 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ENTH PF01417.20 KOO34393.1 - 8.6e-05 22.6 0.0 0.44 10.6 0.0 2.2 2 0 0 2 2 2 2 ENTH domain VHS PF00790.19 KOO34393.1 - 0.0028 17.5 0.0 0.76 9.6 0.0 2.2 2 0 0 2 2 2 2 VHS domain ANTH PF07651.16 KOO34393.1 - 0.0093 15.0 0.1 0.035 13.1 0.0 1.7 2 0 0 2 2 2 1 ANTH domain WD40 PF00400.32 KOO34394.1 - 3.1e-18 65.8 9.5 0.00069 20.4 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO34394.1 - 3.6e-08 33.6 0.0 0.025 14.9 0.0 3.7 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO34394.1 - 0.013 15.4 0.0 0.073 12.9 0.0 2.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A RF-1 PF00472.20 KOO34395.1 - 7.6e-38 129.0 1.1 1.4e-37 128.2 1.1 1.4 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.18 KOO34395.1 - 1.5e-25 90.2 0.8 1.5e-25 90.2 0.8 1.9 2 0 0 2 2 2 1 PCRF domain Lamp PF01299.17 KOO34395.1 - 0.069 13.0 0.0 0.096 12.5 0.0 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) MucB_RseB PF03888.14 KOO34396.1 - 0.078 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 MucB/RseB N-terminal domain cNMP_binding PF00027.29 KOO34397.1 - 0.028 14.5 0.0 0.091 12.8 0.0 1.9 2 0 0 2 2 2 0 Cyclic nucleotide-binding domain zf-RING_2 PF13639.6 KOO34398.1 - 1.4e-10 41.3 9.8 3.5e-10 40.1 9.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KOO34398.1 - 5.9e-09 36.1 12.2 4.5e-08 33.3 12.2 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOO34398.1 - 1.1e-06 28.4 7.9 2.2e-06 27.4 7.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO34398.1 - 1.3e-06 28.1 5.7 1.3e-06 28.1 5.7 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO34398.1 - 1.8e-06 27.7 8.1 1.8e-06 27.7 8.1 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO34398.1 - 6.7e-05 22.8 5.5 0.00015 21.7 5.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 KOO34398.1 - 0.0018 18.3 6.1 0.0055 16.7 6.1 1.8 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 KOO34398.1 - 0.002 18.0 7.7 0.002 18.0 7.7 1.8 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOO34398.1 - 0.0023 18.0 4.8 0.0055 16.8 4.8 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 KOO34398.1 - 0.0043 16.6 5.7 0.0043 16.6 5.7 1.8 2 0 0 2 2 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 KOO34398.1 - 0.017 15.0 6.6 0.033 14.0 6.6 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 KOO34398.1 - 0.18 11.6 12.0 0.11 12.2 9.6 2.0 2 0 0 2 2 2 0 RING-like zinc finger Cid2 PF09774.9 KOO34398.1 - 0.21 12.0 0.2 0.36 11.2 0.2 1.3 1 0 0 1 1 1 0 Caffeine-induced death protein 2 FANCL_C PF11793.8 KOO34398.1 - 0.67 10.2 5.9 3.3 8.0 5.9 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 KOO34398.1 - 2.7 8.4 8.7 6 7.3 8.7 1.6 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 KOO34398.1 - 4.7 7.1 6.4 18 5.3 6.4 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Mitoc_L55 PF09776.9 KOO34399.1 - 0.00015 21.5 4.1 1.4 8.6 0.0 5.7 2 1 4 6 6 6 3 Mitochondrial ribosomal protein L55 LRR_5 PF13306.6 KOO34400.1 - 3.8e-67 224.1 1.0 1.7e-39 134.7 0.1 2.2 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO34400.1 - 1.2e-12 47.4 0.0 0.054 13.3 0.0 7.1 2 1 6 8 8 8 6 Leucine rich repeat Sporozoite_P67 PF05642.11 KOO34401.1 - 6.5 4.7 6.9 12 3.8 2.2 2.3 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Piwi PF02171.17 KOO34402.1 - 7.4e-65 219.2 0.0 1.1e-64 218.7 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 KOO34402.1 - 1.4e-09 37.9 0.0 5e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 PAZ domain VWA_3 PF13768.6 KOO34402.1 - 0.043 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain UPF0242 PF06785.11 KOO34404.1 - 0.011 15.8 7.1 0.011 15.8 7.1 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3972 PF13118.6 KOO34404.1 - 0.48 10.9 6.2 1.7 9.1 6.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3972) EcoEI_R_C PF08463.10 KOO34404.1 - 0.56 10.3 6.7 1 9.4 6.7 1.4 1 0 0 1 1 1 0 EcoEI R protein C-terminal Atg14 PF10186.9 KOO34404.1 - 1.4 8.0 16.5 2.4 7.2 16.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5446 PF17522.2 KOO34404.1 - 1.4 9.1 7.1 0.58 10.4 3.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5446) Fez1 PF06818.15 KOO34404.1 - 1.4 9.3 21.8 2.4 8.5 21.8 1.3 1 0 0 1 1 1 0 Fez1 Exonuc_VII_L PF02601.15 KOO34404.1 - 3.3 7.2 14.8 5.8 6.4 14.8 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF16 PF01519.16 KOO34404.1 - 6.4 7.3 10.3 0.4 11.2 3.1 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 FapA PF03961.13 KOO34404.1 - 8.9 4.8 8.4 17 3.9 8.4 1.5 1 0 0 1 1 1 0 Flagellar Assembly Protein A LRR_5 PF13306.6 KOO34405.1 - 1.3e-219 717.0 9.6 2e-45 153.9 0.0 6.0 2 2 4 6 6 6 6 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO34405.1 - 9.5e-30 102.2 0.0 0.09 12.6 0.0 13.1 4 2 12 17 17 17 12 Leucine rich repeat Peptidase_M8 PF01457.16 KOO34405.1 - 0.073 11.7 14.4 3.1 6.4 0.1 7.0 2 2 5 10 10 10 0 Leishmanolysin DUF1565 PF07602.11 KOO34405.1 - 0.1 11.9 0.0 1.2e+02 1.9 0.0 4.7 4 1 1 5 5 5 0 Protein of unknown function (DUF1565) NTP_transf_8 PF12281.8 KOO34405.1 - 0.12 12.4 0.3 51 3.8 0.0 4.8 4 2 2 7 7 7 0 Nucleotidyltransferase PRC PF05239.16 KOO34405.1 - 0.15 12.1 0.0 11 6.1 0.0 2.3 2 0 0 2 2 2 0 PRC-barrel domain Ank_2 PF12796.7 KOO34407.1 - 8.1e-28 96.9 0.0 7.1e-11 42.5 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34407.1 - 8.6e-27 93.2 1.0 6.4e-11 42.6 0.0 4.9 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO34407.1 - 2.4e-23 81.9 6.0 3.2e-07 30.5 0.0 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34407.1 - 2.2e-20 70.6 0.7 0.0031 17.9 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 KOO34407.1 - 2.5e-16 59.3 7.4 0.0058 17.0 0.0 5.2 5 0 0 5 5 5 5 Ankyrin repeat Ribosomal_S21e PF01249.18 KOO34410.1 - 1.5e-35 121.2 0.0 1.8e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S21e LrgB PF04172.16 KOO34411.1 - 1.9e-36 125.6 16.1 1.9e-36 125.6 16.1 1.8 2 0 0 2 2 2 1 LrgB-like family LrgA PF03788.14 KOO34411.1 - 0.0042 17.0 17.1 0.035 14.1 3.5 3.5 2 1 1 3 3 3 2 LrgA family MgsA_C PF12002.8 KOO34411.1 - 0.82 9.6 2.5 11 5.9 0.1 2.3 1 1 1 2 2 2 0 MgsA AAA+ ATPase C terminal Methyltransf_31 PF13847.6 KOO34412.1 - 1.4e-23 83.3 0.0 2.1e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO34412.1 - 2.1e-23 82.8 0.0 4.2e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO34412.1 - 2.2e-23 82.8 0.0 4e-23 81.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO34412.1 - 3.8e-21 75.6 0.0 6e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO34412.1 - 8e-17 61.8 0.0 1.5e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO34412.1 - 2.4e-13 50.0 0.0 3.2e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 KOO34412.1 - 3.1e-12 46.4 0.0 4.9e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 KOO34412.1 - 3.2e-08 32.6 0.0 4.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_4 PF02390.17 KOO34412.1 - 1.2e-06 28.1 0.0 0.00037 20.0 0.0 2.4 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_PK PF05891.12 KOO34412.1 - 1.3e-05 24.8 0.0 2.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase MTS PF05175.14 KOO34412.1 - 2.8e-05 23.7 0.0 5.6e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 KOO34412.1 - 7.9e-05 22.5 0.0 0.00012 21.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NAS PF03059.16 KOO34412.1 - 0.00013 21.5 0.0 0.00017 21.1 0.0 1.1 1 0 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_8 PF05148.15 KOO34412.1 - 0.00017 21.5 0.0 0.00046 20.1 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase DREV PF05219.12 KOO34412.1 - 0.0004 19.6 0.0 0.00091 18.4 0.0 1.5 2 0 0 2 2 2 1 DREV methyltransferase Methyltransf_32 PF13679.6 KOO34412.1 - 0.0013 18.7 0.0 0.002 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 KOO34412.1 - 0.0024 17.5 0.0 0.0038 16.8 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW NodS PF05401.11 KOO34412.1 - 0.0086 15.7 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) ADH_zinc_N PF00107.26 KOO34412.1 - 0.012 15.6 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase TehB PF03848.14 KOO34412.1 - 0.017 14.6 0.0 0.039 13.4 0.0 1.7 2 1 0 2 2 1 0 Tellurite resistance protein TehB Methyltransf_2 PF00891.18 KOO34412.1 - 0.02 14.2 0.0 0.053 12.8 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase domain Methyltransf_9 PF08003.11 KOO34412.1 - 0.023 13.6 0.0 0.03 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) FtsJ PF01728.19 KOO34412.1 - 0.024 14.8 0.0 0.079 13.1 0.0 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase DUF5305 PF17231.2 KOO34412.1 - 0.086 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF938 PF06080.12 KOO34412.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Shikimate_DH PF01488.20 KOO34412.1 - 0.18 11.9 0.0 0.28 11.3 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Methyltransf_5 PF01795.19 KOO34412.1 - 0.22 11.0 0.0 6.8 6.1 0.0 2.1 2 0 0 2 2 2 0 MraW methylase family EF-hand_1 PF00036.32 KOO34413.1 - 1.3e-09 36.9 0.0 0.0058 16.1 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KOO34413.1 - 8.2e-09 34.7 0.0 0.0052 16.6 0.0 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KOO34413.1 - 1.8e-07 30.3 0.1 0.033 13.7 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO34413.1 - 1.9e-07 31.4 0.1 0.096 13.2 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO34413.1 - 1e-05 25.3 0.1 0.07 13.0 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair GAS PF13851.6 KOO34413.1 - 6.3 6.1 16.7 3.2 7.1 0.7 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DehI PF10778.9 KOO34413.1 - 9.4 6.4 10.3 85 3.3 10.3 2.3 1 1 0 1 1 1 0 Halocarboxylic acid dehydrogenase DehI Chromo PF00385.24 KOO34414.1 - 0.04 13.8 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain tRNA-synt_1g PF09334.11 KOO34416.1 - 6.4e-94 314.9 0.0 4.2e-91 305.6 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) FH2 PF02181.23 KOO34416.1 - 1.2e-37 130.0 0.0 2.4e-37 129.0 0.0 1.4 1 0 0 1 1 1 1 Formin Homology 2 Domain tRNA-synt_1 PF00133.22 KOO34416.1 - 4.3e-28 97.9 0.0 1.9e-16 59.5 0.0 3.1 3 0 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA_bind PF01588.20 KOO34416.1 - 4.2e-27 94.1 1.4 3.3e-26 91.2 0.3 2.4 2 0 0 2 2 2 1 Putative tRNA binding domain NDK PF00334.19 KOO34416.1 - 1.3e-18 67.4 0.0 2.4e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 Nucleoside diphosphate kinase tRNA-synt_1e PF01406.19 KOO34416.1 - 5.1e-12 45.7 0.0 4.2e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Pepdidase_M14_N PF18027.1 KOO34416.1 - 1.9e-11 44.3 0.0 4.7e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain tRNA-synt_1f PF01921.18 KOO34416.1 - 0.00064 18.7 0.0 0.21 10.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (K) PABP PF00658.18 KOO34417.1 - 2.3e-08 34.1 0.1 5.4e-08 32.9 0.1 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain OTU PF02338.19 KOO34417.1 - 0.15 12.5 0.0 0.36 11.3 0.0 1.6 1 0 0 1 1 1 0 OTU-like cysteine protease RAP1 PF07218.11 KOO34417.1 - 8 4.6 6.5 12 4.1 6.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) LRR_6 PF13516.6 KOO34420.1 - 1.1e-56 184.1 25.9 0.00033 20.5 0.0 13.7 13 0 0 13 13 13 12 Leucine Rich repeat NACHT PF05729.12 KOO34420.1 - 2.8e-05 24.1 0.1 6.4e-05 22.9 0.1 1.7 1 0 0 1 1 1 1 NACHT domain SpoU_sub_bind PF08032.12 KOO34420.1 - 0.0042 17.3 12.7 3.3 8.1 0.0 6.4 4 3 3 7 7 7 2 RNA 2'-O ribose methyltransferase substrate binding LRR_1 PF00560.33 KOO34420.1 - 0.0048 17.2 0.0 42 5.2 0.1 6.8 10 0 0 10 10 10 0 Leucine Rich Repeat AAA_19 PF13245.6 KOO34420.1 - 0.12 12.7 0.0 0.37 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain EIF_2_alpha PF07541.12 KOO34420.1 - 0.25 11.5 4.7 8.4 6.5 0.3 4.2 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit LRR_4 PF12799.7 KOO34420.1 - 0.25 11.8 16.7 11 6.6 0.2 6.8 5 2 5 10 10 10 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO34420.1 - 3.2 7.6 9.8 12 5.8 0.0 6.0 7 2 0 7 7 7 0 Leucine rich repeat EF-hand_6 PF13405.6 KOO34421.1 - 2.8e-11 42.4 2.0 2.6e-05 23.8 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO34421.1 - 1.2e-10 40.2 2.0 3.3e-05 23.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34421.1 - 1.7e-09 38.0 0.3 3.1e-09 37.1 0.2 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO34421.1 - 1.1e-08 34.1 1.8 0.00076 18.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 KOO34421.1 - 6.7e-06 25.9 0.2 0.084 12.7 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 KOO34421.1 - 0.00012 22.0 1.2 0.25 11.3 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.6 KOO34421.1 - 0.00057 19.7 2.2 0.074 12.9 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO34422.1 - 5.9e-13 47.4 0.6 2.7e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO34422.1 - 1.1e-12 46.7 0.4 4.8e-05 23.0 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO34422.1 - 2.4e-11 43.9 0.1 8.3e-06 26.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO34422.1 - 1.1e-10 41.2 0.6 0.00027 20.7 0.1 2.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO34422.1 - 2e-08 33.4 1.5 0.0005 19.4 0.2 2.2 2 0 0 2 2 2 2 EF hand Caleosin PF05042.13 KOO34422.1 - 0.016 15.2 0.2 0.1 12.5 0.1 1.9 1 1 1 2 2 2 0 Caleosin related protein EF-hand_4 PF12763.7 KOO34422.1 - 0.06 13.3 1.5 3 7.8 0.2 2.1 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 KOO34423.1 - 1.7e-11 42.8 1.0 5.7e-05 22.4 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34423.1 - 3.1e-09 37.2 0.3 5.1e-09 36.5 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO34423.1 - 1.9e-07 30.4 0.3 0.00015 21.4 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO34423.1 - 2.5e-07 30.4 3.1 5e-06 26.3 0.4 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO34423.1 - 1e-05 24.8 0.7 0.0067 15.9 0.1 2.4 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 KOO34423.1 - 0.22 11.9 0.0 0.39 11.1 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Mito_fiss_reg PF05308.11 KOO34423.1 - 0.89 9.6 5.1 2.8 7.9 2.2 2.6 2 0 0 2 2 2 0 Mitochondrial fission regulator TrkH PF02386.16 KOO34424.1 - 1.4e-22 79.8 8.2 2.1e-15 56.2 0.5 3.0 3 0 0 3 3 3 3 Cation transport protein TAF4 PF05236.14 KOO34429.1 - 0.11 12.3 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Arm PF00514.23 KOO34431.1 - 5.9e-26 89.7 12.4 1.9e-08 34.1 0.1 5.7 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat U-box PF04564.15 KOO34431.1 - 7.3e-13 48.5 0.0 1.4e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain UPF0020 PF01170.18 KOO34431.1 - 5.4e-09 36.0 5.0 6.6e-08 32.5 0.1 2.9 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 zf-Nse PF11789.8 KOO34431.1 - 4.7e-05 23.1 0.0 9.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Methyltransf_25 PF13649.6 KOO34431.1 - 0.00012 22.7 0.0 0.00012 22.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO34431.1 - 0.00036 21.1 0.0 0.0012 19.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Atx10homo_assoc PF09759.9 KOO34431.1 - 0.0065 16.5 0.0 2.4 8.2 0.0 3.1 1 1 1 3 3 3 1 Spinocerebellar ataxia type 10 protein domain zf-NOSIP PF15906.5 KOO34431.1 - 0.014 15.5 0.0 0.034 14.3 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_UBOX PF13445.6 KOO34431.1 - 0.07 13.2 0.1 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 RING-type zinc-finger DUF4407 PF14362.6 KOO34431.1 - 0.17 11.2 9.3 0.34 10.2 9.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Arm_2 PF04826.13 KOO34431.1 - 0.32 10.4 0.0 11 5.3 0.0 2.1 1 1 1 2 2 2 0 Armadillo-like DUF1690 PF07956.11 KOO34431.1 - 0.53 10.7 5.8 0.97 9.9 5.8 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DivIVA PF05103.13 KOO34431.1 - 5.4 7.1 14.6 11 6.1 14.6 1.5 1 0 0 1 1 1 0 DivIVA protein Csm1_N PF18504.1 KOO34431.1 - 7 7.1 8.2 2.7 8.4 1.1 2.6 1 1 2 3 3 3 0 Csm1 N-terminal domain DUF3138 PF11336.8 KOO34431.1 - 7.1 5.1 11.1 14 4.1 11.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) PP2C PF00481.21 KOO34432.1 - 2.8e-47 161.5 0.0 3.3e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO34432.1 - 1e-05 25.3 0.3 2.2e-05 24.2 0.1 1.7 2 1 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO34432.1 - 3.5e-05 23.8 0.3 0.00029 20.8 0.3 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) MccV PF17508.2 KOO34433.1 - 9.2 6.9 10.9 1.6 9.3 6.0 2.0 2 0 0 2 2 2 0 Microcin V bacteriocin SHIPPO-rpt PF07004.12 KOO34434.1 - 3.6e-09 37.1 5.4 0.25 12.3 0.1 4.7 4 1 0 4 4 4 3 Sperm-tail PG-rich repeat Pro_isomerase PF00160.21 KOO34435.1 - 2.8e-21 76.4 0.0 4.8e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Orthoreo_P10 PF07204.11 KOO34435.1 - 0.13 12.2 0.1 0.27 11.2 0.1 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 SBF PF01758.16 KOO34436.1 - 4.8e-14 52.5 7.8 4.8e-14 52.5 7.8 1.6 2 0 0 2 2 2 1 Sodium Bile acid symporter family Mem_trans PF03547.18 KOO34436.1 - 1.2 7.5 8.5 0.035 12.5 1.4 2.0 2 1 1 3 3 3 0 Membrane transport protein GFA PF04828.14 KOO34437.1 - 8.5e-06 26.0 0.5 2e-05 24.9 0.5 1.6 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme EBP50_C PF09007.11 KOO34438.1 - 2.3 9.2 6.5 20 6.1 1.0 2.2 2 0 0 2 2 2 0 EBP50, C-terminal LRR_6 PF13516.6 KOO34439.1 - 1.7e-25 86.8 25.6 9.1e-07 28.4 0.1 7.8 7 0 0 7 7 7 6 Leucine Rich repeat LRR_8 PF13855.6 KOO34439.1 - 0.0002 21.1 22.6 0.28 11.0 9.6 5.6 3 2 1 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 KOO34439.1 - 0.0015 18.8 8.7 51 5.0 0.1 6.3 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO34439.1 - 0.14 12.6 26.8 0.24 11.9 3.1 5.1 3 1 4 7 7 7 0 Leucine Rich repeats (2 copies) NHL PF01436.21 KOO34440.1 - 5.1e-25 86.2 9.9 0.00014 21.7 0.4 6.3 6 0 0 6 6 6 5 NHL repeat PQQ_3 PF13570.6 KOO34440.1 - 1.5e-06 28.5 0.8 0.29 11.7 0.0 4.2 4 0 0 4 4 4 2 PQQ-like domain SGL PF08450.12 KOO34440.1 - 0.00024 20.8 0.0 0.029 13.9 0.0 2.9 2 2 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 KOO34440.1 - 0.059 13.3 0.0 7 6.5 0.0 3.4 2 1 0 2 2 2 0 Esterase-like activity of phytase DUF5128 PF17170.4 KOO34440.1 - 0.075 12.2 0.0 0.83 8.7 0.0 2.1 2 0 0 2 2 2 0 6-bladed beta-propeller DUF3456 PF11938.8 KOO34441.1 - 3.6e-22 79.6 0.0 5.5e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP ABC_tran PF00005.27 KOO34443.1 - 2.3e-11 44.4 0.0 3.7e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SbcCD_C PF13558.6 KOO34443.1 - 0.0095 16.2 0.0 0.11 12.7 0.0 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 KOO34443.1 - 0.011 16.0 0.0 0.023 14.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KOO34443.1 - 0.19 11.5 0.2 1.3 8.7 0.1 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein Filament PF00038.21 KOO34444.1 - 2.2 7.8 54.3 1.3 8.5 37.0 2.6 1 1 1 2 2 2 0 Intermediate filament protein PP2C PF00481.21 KOO34445.1 - 8.3e-16 58.4 0.0 9.9e-13 48.3 0.0 2.0 1 1 1 2 2 2 2 Protein phosphatase 2C EF-hand_7 PF13499.6 KOO34447.1 - 6.1e-10 39.4 0.1 9.4e-10 38.8 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO34447.1 - 1.2e-09 37.0 1.5 2.8e-05 23.3 0.4 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO34447.1 - 3.9e-06 26.3 0.5 0.027 14.4 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO34447.1 - 7.7e-05 22.5 1.7 0.32 10.9 0.4 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO34447.1 - 0.00021 21.5 0.0 0.0004 20.6 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO34447.1 - 0.0021 17.5 1.0 0.04 13.4 0.0 2.5 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.9 KOO34447.1 - 0.055 13.8 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO34447.1 - 0.11 12.5 0.1 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Rhodanese PF00581.20 KOO34448.1 - 0.00015 22.3 0.0 0.00018 22.0 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain NAD_binding_1 PF00175.21 KOO34449.1 - 1.5e-27 96.3 0.0 2.5e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOO34449.1 - 0.00015 22.1 0.0 0.00028 21.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain DEAD PF00270.29 KOO34450.1 - 1.2e-35 122.9 0.0 1.9e-35 122.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO34450.1 - 1.1e-19 70.8 0.0 6.7e-19 68.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO34450.1 - 0.0066 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3731 PF12531.8 KOO34451.1 - 0.089 12.6 0.6 0.3 10.9 0.0 2.1 3 0 0 3 3 3 0 DNA-K related protein SLC12 PF03522.15 KOO34453.1 - 2.8e-16 59.6 2.5 4.1e-16 59.1 2.2 1.4 1 1 0 1 1 1 1 Solute carrier family 12 Pkinase PF00069.25 KOO34454.1 - 2.5e-37 128.7 0.0 4.6e-37 127.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34454.1 - 5.1e-37 127.6 0.0 1.9e-36 125.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase DUF4448 PF14610.6 KOO34454.1 - 0.0065 16.3 0.1 0.013 15.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) FTA2 PF13095.6 KOO34454.1 - 0.066 12.8 0.0 5.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 CRC_subunit PF08624.10 KOO34454.1 - 0.32 11.4 0.6 3 8.3 0.0 2.4 3 0 0 3 3 3 0 Chromatin remodelling complex Rsc7/Swp82 subunit CASP_C PF08172.12 KOO34454.1 - 0.37 10.1 1.9 0.85 8.9 1.9 1.6 1 0 0 1 1 1 0 CASP C terminal Cas9_Topo PF17894.1 KOO34455.1 - 0.12 12.4 0.8 0.31 11.1 0.7 1.8 1 1 0 1 1 1 0 Topo homolgy domain in CRISPR-associated endonuclease Cas9 DUF87 PF01935.17 KOO34455.1 - 0.64 10.1 3.6 0.76 9.8 3.6 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain THRAP3_BCLAF1 PF15440.6 KOO34455.1 - 1.4 7.8 11.9 1.6 7.6 11.9 1.0 1 0 0 1 1 1 0 THRAP3/BCLAF1 family DUF4407 PF14362.6 KOO34455.1 - 1.9 7.8 15.9 7.1 5.9 5.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 KOO34455.1 - 3.4 6.5 4.0 3.8 6.3 4.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Efg1 PF10153.9 KOO34455.1 - 3.9 7.9 14.3 1.1 9.6 10.9 1.8 1 1 1 2 2 2 0 rRNA-processing protein Efg1 Glyco_hydro_127 PF07944.12 KOO34456.1 - 8e-59 199.5 0.0 1.2e-58 198.9 0.0 1.3 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 GLTP PF08718.11 KOO34457.1 - 4.7e-32 111.3 0.0 6.8e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF2810 PF10928.8 KOO34457.1 - 0.053 13.5 0.2 0.91 9.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2810) DUF1275 PF06912.11 KOO34458.1 - 7.8e-16 58.6 4.8 1.1e-15 58.1 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) PDZ PF00595.24 KOO34458.1 - 0.00022 21.5 0.0 0.00038 20.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain CRM1_C PF08767.11 KOO34459.1 - 0.013 14.7 0.0 0.016 14.4 0.0 1.1 1 0 0 1 1 1 0 CRM1 C terminal FKBP_N PF01346.18 KOO34463.1 - 0.15 13.1 0.6 0.28 12.2 0.6 1.4 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase IBN_N PF03810.19 KOO34464.1 - 0.0038 17.1 0.1 0.16 11.9 0.1 2.3 1 1 1 2 2 2 2 Importin-beta N-terminal domain DUF3203 PF11462.8 KOO34465.1 - 0.17 12.1 0.6 0.31 11.2 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3203) Ank_2 PF12796.7 KOO34467.1 - 1.7e-17 63.7 0.1 1.2e-10 41.8 0.1 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO34467.1 - 1.4e-13 50.8 0.3 0.00012 22.2 0.1 5.3 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO34467.1 - 4.4e-13 49.5 0.2 2.6e-05 24.7 0.0 4.0 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO34467.1 - 2.7e-11 43.4 0.4 5.2e-05 23.5 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat EF-hand_1 PF00036.32 KOO34467.1 - 3.3e-10 38.8 2.1 0.00017 20.9 0.1 3.0 2 0 0 2 2 2 2 EF hand Ank_3 PF13606.6 KOO34467.1 - 1.4e-08 34.3 0.1 0.041 14.4 0.0 5.1 4 2 0 4 4 4 2 Ankyrin repeat EF-hand_7 PF13499.6 KOO34467.1 - 6.5e-07 29.7 0.8 1.5e-06 28.5 0.8 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO34467.1 - 0.00045 19.9 0.2 0.28 11.2 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_11 PF08976.11 KOO34467.1 - 0.0081 17.0 0.0 0.015 16.1 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO34467.1 - 0.014 15.4 0.2 0.036 14.0 0.2 1.7 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand HycA_repressor PF11046.8 KOO34467.1 - 0.061 13.5 0.1 0.24 11.6 0.0 1.9 2 0 0 2 2 2 0 Transcriptional repressor of hyc and hyp operons Gamma_PGA_hydro PF05908.11 KOO34467.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase EF-hand_8 PF13833.6 KOO34467.1 - 0.67 9.9 4.8 4.9 7.1 3.2 2.9 2 2 0 2 2 2 0 EF-hand domain pair Pkinase_Tyr PF07714.17 KOO34469.1 - 1.3e-31 109.8 0.0 1.9e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO34469.1 - 4.1e-31 108.3 0.0 5.6e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO34469.1 - 0.0024 17.8 0.7 0.01 15.8 0.4 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO34469.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 KOO34469.1 - 0.078 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 KOO34469.1 - 0.2 11.0 0.3 0.3 10.4 0.3 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ADIP PF11559.8 KOO34470.1 - 1.2e-06 28.7 6.5 1.2e-06 28.7 6.5 2.1 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding Antimicrobial24 PF16049.5 KOO34470.1 - 0.96 9.5 3.3 2.1 8.4 3.3 1.5 1 0 0 1 1 1 0 Frog antimicrobial peptide AAA_13 PF13166.6 KOO34470.1 - 4 6.0 6.5 5.5 5.5 6.5 1.2 1 0 0 1 1 1 0 AAA domain GAS PF13851.6 KOO34470.1 - 6.8 6.0 15.6 2.3 7.5 1.7 3.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Kinesin PF00225.23 KOO34471.1 - 4e-103 344.9 0.1 4e-103 344.9 0.1 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOO34471.1 - 3.9e-23 82.0 0.0 8.1e-23 81.0 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Filament PF00038.21 KOO34471.1 - 2.1 7.8 55.9 0.088 12.4 9.3 3.5 1 1 2 3 3 3 0 Intermediate filament protein zf-C4H2 PF10146.9 KOO34473.1 - 0.0056 17.0 0.4 0.0068 16.7 0.4 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein LUC7 PF03194.15 KOO34473.1 - 0.037 13.7 1.2 0.037 13.7 1.2 1.1 1 0 0 1 1 1 0 LUC7 N_terminus Baculo_ME53 PF06061.11 KOO34473.1 - 0.076 12.2 0.6 0.098 11.9 0.6 1.0 1 0 0 1 1 1 0 Baculoviridae ME53 YabA PF06156.13 KOO34473.1 - 0.3 11.7 3.8 0.17 12.5 1.0 1.8 1 1 1 2 2 2 0 Initiation control protein YabA BST2 PF16716.5 KOO34473.1 - 1.3 9.7 6.4 0.24 12.0 2.4 1.7 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 EF-hand_1 PF00036.32 KOO34474.1 - 4.6e-22 75.9 0.2 1.7e-05 24.1 0.1 4.9 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO34474.1 - 8.1e-22 77.5 0.0 8.7e-13 48.5 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO34474.1 - 1.5e-20 71.3 0.0 2.4e-05 23.9 0.0 4.8 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 KOO34474.1 - 3.3e-12 45.3 2.7 0.0011 18.3 0.0 4.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO34474.1 - 2.9e-11 43.0 3.0 0.0018 18.1 0.0 4.5 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_9 PF14658.6 KOO34474.1 - 0.0011 19.3 0.0 0.35 11.2 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain Kinesin PF00225.23 KOO34475.1 - 3.7e-92 308.8 0.0 9.4e-92 307.5 0.0 1.8 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO34475.1 - 2.1e-14 53.7 0.0 1.9e-13 50.6 0.0 2.6 2 1 0 2 2 2 1 Microtubule binding FapA PF03961.13 KOO34475.1 - 3.5 6.1 21.1 0.42 9.2 0.2 3.4 3 1 1 4 4 4 0 Flagellar Assembly Protein A Hydrolase_4 PF12146.8 KOO34479.1 - 2.6e-13 49.8 0.0 3.2e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO34479.1 - 9.6e-12 46.0 0.1 1.3e-11 45.5 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO34479.1 - 5.6e-08 32.7 0.1 8.8e-08 32.1 0.1 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 KOO34479.1 - 0.012 14.5 0.3 0.025 13.5 0.3 1.5 1 1 0 1 1 1 0 Chlorophyllase enzyme RMMBL PF07521.12 KOO34479.1 - 0.051 13.5 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain EF-hand_1 PF00036.32 KOO34480.1 - 6.4e-08 31.6 0.1 0.00055 19.3 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34480.1 - 1.2e-06 28.9 0.1 2.7e-06 27.7 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO34480.1 - 2e-05 24.2 0.1 0.0031 17.3 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO34480.1 - 0.00023 20.5 0.4 0.00099 18.5 0.4 2.0 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KOO34480.1 - 0.00029 20.6 0.1 0.49 10.3 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair VWA_2 PF13519.6 KOO34481.1 - 0.0015 19.2 0.0 0.0072 17.0 0.0 2.1 1 1 0 1 1 1 1 von Willebrand factor type A domain OKR_DC_1_N PF03709.15 KOO34481.1 - 0.0083 16.4 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain VWA PF00092.28 KOO34481.1 - 0.015 15.5 0.1 0.11 12.7 0.1 2.3 2 1 0 2 2 2 0 von Willebrand factor type A domain Exo_endo_phos PF03372.23 KOO34482.1 - 0.00014 21.4 0.0 0.00025 20.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CENP-H PF05837.12 KOO34482.1 - 0.022 15.2 3.2 0.034 14.6 3.2 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) OmpH PF03938.14 KOO34482.1 - 0.035 14.5 2.1 0.055 13.8 2.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ADIP PF11559.8 KOO34482.1 - 0.13 12.3 3.8 0.21 11.7 3.8 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding UPF0242 PF06785.11 KOO34482.1 - 0.16 12.0 2.3 0.26 11.4 2.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 KOO34482.1 - 0.19 10.8 1.5 0.25 10.4 1.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 KOO34482.1 - 0.31 9.9 4.2 0.41 9.5 4.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.8 KOO34482.1 - 1.2 6.5 7.8 0.95 6.9 6.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Ank_2 PF12796.7 KOO34484.1 - 3.5e-61 203.8 5.3 4.9e-16 59.1 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34484.1 - 4.3e-50 167.5 11.9 6.7e-10 39.3 0.0 7.0 3 1 5 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 KOO34484.1 - 9e-44 146.1 12.3 8.6e-05 22.8 0.3 9.9 9 1 1 10 10 10 9 Ankyrin repeat Ank_5 PF13857.6 KOO34484.1 - 9.7e-38 127.7 9.7 1.2e-07 31.8 0.0 8.6 1 1 9 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34484.1 - 3.1e-34 113.1 11.1 3.5e-05 23.9 0.0 9.9 10 0 0 10 10 10 6 Ankyrin repeat GILT PF03227.16 KOO34484.1 - 5.3e-06 26.6 15.5 3.2 8.1 0.4 6.6 1 1 5 6 6 6 3 Gamma interferon inducible lysosomal thiol reductase (GILT) Robl_LC7 PF03259.17 KOO34484.1 - 0.0045 16.7 0.0 9.9 6.0 0.0 3.8 2 1 2 4 4 4 1 Roadblock/LC7 domain DUF1847 PF08901.11 KOO34484.1 - 0.014 15.1 9.5 0.6 9.7 0.3 3.8 1 1 1 3 3 3 0 Protein of unknown function (DUF1847) Y_phosphatase PF00102.27 KOO34484.1 - 0.16 11.5 0.2 12 5.3 0.0 3.5 2 2 1 3 3 3 0 Protein-tyrosine phosphatase XPG_I PF00867.18 KOO34484.1 - 1 9.8 7.7 8.5 6.8 0.5 4.0 4 0 0 4 4 4 0 XPG I-region GST_N_5 PF18485.1 KOO34484.1 - 1.8 9.0 13.0 11 6.5 0.0 5.8 7 1 1 8 8 8 0 Glutathione S-transferase, N-terminal domain ADAM_CR PF08516.12 KOO34484.1 - 4.4 7.7 12.8 2.1 8.8 2.8 3.9 2 1 2 4 4 4 0 ADAM cysteine-rich Yip1 PF04893.17 KOO34485.1 - 5e-13 49.1 9.3 6.7e-13 48.7 9.3 1.1 1 0 0 1 1 1 1 Yip1 domain Cadherin_C_2 PF16492.5 KOO34486.1 - 4.8e-07 30.4 1.2 12 6.8 0.1 5.2 5 0 0 5 5 5 4 Cadherin cytoplasmic C-terminal CE2_N PF17996.1 KOO34486.1 - 8.9e-05 22.4 0.1 20 5.2 0.0 4.6 5 0 0 5 5 5 1 Carbohydrate esterase 2 N-terminal RS4NT PF08071.12 KOO34486.1 - 0.035 14.2 0.0 20 5.4 0.0 3.0 3 0 0 3 3 3 0 RS4NT (NUC023) domain tRNA_int_endo PF01974.17 KOO34486.1 - 0.037 14.1 5.9 21 5.3 0.1 4.0 4 0 0 4 4 4 0 tRNA intron endonuclease, catalytic C-terminal domain Macin PF14865.6 KOO34487.1 - 0.13 12.8 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 Macin Chromo PF00385.24 KOO34490.1 - 8.6e-14 51.2 1.5 1.6e-13 50.3 1.5 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SH3_3 PF08239.11 KOO34490.1 - 0.011 16.0 0.1 0.037 14.3 0.1 2.0 1 0 0 1 1 1 0 Bacterial SH3 domain CD99L2 PF12301.8 KOO34490.1 - 0.2 11.9 4.4 1 9.7 0.8 2.5 2 0 0 2 2 2 0 CD99 antigen like protein 2 ADPrib_exo_Tox PF03496.14 KOO34491.1 - 4.6e-05 22.8 0.0 0.016 14.6 0.0 2.7 3 0 0 3 3 3 2 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO34491.1 - 0.0021 17.4 0.0 0.0068 15.7 0.0 1.8 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase DUF1152 PF06626.12 KOO34492.1 - 0.00057 19.2 0.7 0.66 9.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1152) F-box PF00646.33 KOO34493.1 - 4.4e-05 23.3 0.9 5.6e-05 22.9 0.0 1.6 2 0 0 2 2 2 1 F-box domain SAP PF02037.27 KOO34494.1 - 1.4e-05 24.7 0.2 2.8e-05 23.7 0.2 1.6 1 0 0 1 1 1 1 SAP domain SHIPPO-rpt PF07004.12 KOO34496.1 - 0.0029 18.5 18.9 5.3 8.1 0.1 5.9 6 1 0 6 6 6 4 Sperm-tail PG-rich repeat Methyltransf_3 PF01596.17 KOO34497.1 - 1.6e-58 197.3 0.0 6.7e-37 126.7 0.0 2.9 2 1 0 2 2 2 2 O-methyltransferase Methyltransf_24 PF13578.6 KOO34497.1 - 1.4e-28 100.0 3.7 1.3e-14 55.1 0.0 3.0 4 0 0 4 4 3 2 Methyltransferase domain PCMT PF01135.19 KOO34497.1 - 7.7e-16 58.5 0.0 3.8e-07 30.1 0.0 2.3 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOO34497.1 - 1.5e-14 54.0 0.0 5.8e-07 29.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 KOO34497.1 - 1.1e-10 42.0 1.1 2.8e-05 24.7 0.0 2.9 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.7 KOO34497.1 - 3.6e-07 30.2 0.0 0.028 14.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 KOO34497.1 - 5.1e-07 30.3 0.9 0.0028 18.3 0.0 2.8 3 0 0 3 3 3 2 Methyltransferase domain MTS PF05175.14 KOO34497.1 - 8.2e-07 28.7 0.1 0.02 14.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_12 PF08242.12 KOO34497.1 - 1.8e-06 28.6 0.0 0.0042 17.8 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.6 KOO34497.1 - 2.5e-05 24.2 0.0 0.013 15.3 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain GCD14 PF08704.10 KOO34497.1 - 6e-05 22.8 0.0 0.33 10.6 0.0 2.3 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Cons_hypoth95 PF03602.15 KOO34497.1 - 0.00082 19.1 0.0 0.052 13.2 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical protein 95 TrmK PF04816.12 KOO34497.1 - 0.015 14.8 0.0 4.7 6.7 0.0 2.2 2 0 0 2 2 2 0 tRNA (adenine(22)-N(1))-methyltransferase Cep57_CLD_2 PF14197.6 KOO34497.1 - 0.29 11.3 4.8 12 6.1 0.5 2.7 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF5403 PF17395.2 KOO34497.1 - 0.55 10.6 2.6 40 4.6 0.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5403) Thioredoxin PF00085.20 KOO34498.1 - 2.8e-14 52.9 0.0 6.9e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Acetyltransf_1 PF00583.25 KOO34498.1 - 1.1e-10 41.7 0.0 2.3e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOO34498.1 - 2.1e-07 30.9 0.0 4.1e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO34498.1 - 9.5e-07 28.7 0.0 2.4e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 KOO34498.1 - 4e-06 27.2 0.0 7.9e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Thioredoxin_8 PF13905.6 KOO34498.1 - 7e-05 23.1 0.0 0.0038 17.5 0.0 2.4 1 1 1 2 2 2 1 Thioredoxin-like Acetyltransf_9 PF13527.7 KOO34498.1 - 0.00011 22.3 0.1 0.00028 20.9 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Thioredoxin_2 PF13098.6 KOO34498.1 - 0.00019 21.8 0.0 0.00044 20.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KOO34498.1 - 0.00074 19.7 0.0 0.0029 17.7 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like Dsh_C PF12316.8 KOO34498.1 - 0.0043 17.5 3.9 0.0043 17.5 3.9 1.8 2 0 0 2 2 2 1 Segment polarity protein dishevelled (Dsh) C terminal TraF PF13728.6 KOO34498.1 - 0.0054 16.6 0.0 0.016 15.0 0.0 1.8 1 0 0 1 1 1 1 F plasmid transfer operon protein PEARLI-4 PF05278.12 KOO34499.1 - 0.063 12.9 0.0 0.088 12.4 0.0 1.1 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Exostosin PF03016.15 KOO34501.1 - 4.1e-16 59.1 0.0 5.9e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Exostosin family TBCA PF02970.16 KOO34502.1 - 1.6e-14 54.0 4.3 2.3e-14 53.5 4.3 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor A Porph_ging PF09697.10 KOO34502.1 - 0.062 13.8 0.1 0.084 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (Porph_ging) DUF3022 PF11226.8 KOO34502.1 - 0.1 13.1 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3022) Pkinase PF00069.25 KOO34503.1 - 2.2e-24 86.2 0.0 4.6e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain PARP PF00644.20 KOO34503.1 - 5e-15 55.6 0.0 1e-14 54.6 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase_Tyr PF07714.17 KOO34503.1 - 3.1e-12 46.3 0.0 6e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO34503.1 - 6.6e-06 25.6 0.0 1.8e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2572 PF10833.8 KOO34503.1 - 0.19 11.5 0.3 0.34 10.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Ham1p_like PF01725.16 KOO34504.1 - 1.7e-50 171.5 0.0 1.9e-50 171.4 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Ank_5 PF13857.6 KOO34505.1 - 6.7e-20 70.9 1.3 7.1e-10 38.9 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO34505.1 - 3.7e-16 59.5 0.1 1.8e-08 34.8 0.0 2.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34505.1 - 2.1e-13 50.5 2.2 1.1e-05 25.9 0.2 3.7 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34505.1 - 5.7e-12 44.7 0.1 0.00062 20.0 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOO34505.1 - 1.2e-09 38.1 0.2 0.00036 20.8 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat FH2 PF02181.23 KOO34508.1 - 4.3e-59 200.5 0.0 6.6e-59 199.9 0.0 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Cofilin_ADF PF00241.20 KOO34508.1 - 3.9e-06 26.7 0.0 6.2e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF4679 PF15728.5 KOO34508.1 - 0.13 11.3 2.2 0.24 10.4 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) Glyco_hydro_7 PF00840.20 KOO34509.1 - 3.7e-156 520.2 7.3 5.3e-156 519.7 7.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 GTP_EFTU PF00009.27 KOO34509.1 - 3.4e-54 183.4 0.1 7.3e-54 182.3 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 KOO34509.1 - 2.3e-44 149.9 0.4 2.3e-44 149.9 0.4 2.6 2 0 0 2 2 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 KOO34509.1 - 2.5e-20 72.3 0.0 8.2e-20 70.6 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOO34509.1 - 2.8e-10 40.4 3.5 6.9e-10 39.2 3.5 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KOO34509.1 - 0.00032 20.7 0.0 0.001 19.1 0.0 1.8 1 1 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 KOO34509.1 - 0.0025 17.6 1.1 0.0054 16.6 0.0 2.0 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain AhpC-TSA PF00578.21 KOO34509.1 - 0.015 15.2 0.0 0.1 12.5 0.0 2.2 2 0 0 2 2 2 0 AhpC/TSA family Asp-B-Hydro_N PF05279.11 KOO34509.1 - 0.25 11.4 17.5 0.52 10.3 17.5 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF812 PF05667.11 KOO34509.1 - 0.85 8.4 18.8 1.4 7.8 18.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) GREB1 PF15782.5 KOO34509.1 - 1.7 5.7 10.6 2.4 5.2 10.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Draxin PF15550.6 KOO34509.1 - 7.6 6.3 9.8 13 5.5 9.8 1.3 1 0 0 1 1 1 0 Draxin Hydin_ADK PF17213.3 KOO34509.1 - 9.6 6.4 17.6 20 5.4 17.6 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain SNF2_N PF00176.23 KOO34510.1 - 1.2e-50 172.2 0.0 2.5e-50 171.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_3 PF13920.6 KOO34510.1 - 9.5e-07 28.6 7.6 9.5e-07 28.6 7.6 3.6 3 1 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 KOO34510.1 - 6.9e-06 25.9 10.5 6.9e-06 25.9 10.5 3.7 3 0 0 3 3 3 1 PHD-finger zf-RING_2 PF13639.6 KOO34510.1 - 7.1e-06 26.3 9.2 7.1e-06 26.3 9.2 3.5 3 0 0 3 3 2 1 Ring finger domain Helicase_C PF00271.31 KOO34510.1 - 1.8e-05 25.1 0.0 4.1e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 KOO34510.1 - 3.1e-05 23.9 5.1 8.7e-05 22.5 5.1 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOO34510.1 - 3.7e-05 23.5 7.4 3.7e-05 23.5 7.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO34510.1 - 7.3e-05 22.7 8.3 7.3e-05 22.7 8.3 3.4 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOO34510.1 - 0.00049 19.9 8.0 0.00049 19.9 8.0 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) ERCC3_RAD25_C PF16203.5 KOO34510.1 - 0.0011 18.2 0.0 0.012 14.8 0.0 2.1 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase zf-RING_4 PF14570.6 KOO34510.1 - 0.0078 16.0 6.8 0.0078 16.0 6.8 2.8 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.14 KOO34510.1 - 0.19 11.6 0.7 1.8 8.5 0.1 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_5 PF17121.5 KOO34510.1 - 4.7 7.2 7.7 17 5.4 7.7 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TauE PF01925.19 KOO34511.1 - 1.3e-22 80.6 21.7 2.1e-20 73.4 10.2 2.0 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE Acyl_transf_3 PF01757.22 KOO34513.1 - 2.1e-15 56.6 35.1 1.8e-14 53.6 35.1 2.2 1 1 0 1 1 1 1 Acyltransferase family DUF1624 PF07786.12 KOO34513.1 - 0.23 11.0 9.0 0.45 10.0 2.7 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1624) NHL PF01436.21 KOO34515.1 - 9.8e-28 94.8 7.9 4.8e-09 35.8 0.0 6.2 6 0 0 6 6 6 5 NHL repeat Transglut_core PF01841.19 KOO34515.1 - 4.9e-07 30.2 0.0 1e-06 29.1 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF5128 PF17170.4 KOO34515.1 - 0.0021 17.3 0.0 0.1 11.7 0.0 2.7 3 0 0 3 3 3 1 6-bladed beta-propeller PQQ_3 PF13570.6 KOO34515.1 - 0.0051 17.3 1.2 2.9 8.5 0.0 4.0 4 0 0 4 4 4 1 PQQ-like domain TolB_like PF15869.5 KOO34515.1 - 0.011 15.0 0.0 0.73 9.0 0.0 2.6 1 1 1 3 3 3 0 TolB-like 6-blade propeller-like SGL PF08450.12 KOO34515.1 - 0.019 14.6 0.0 0.53 9.8 0.0 2.8 3 1 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Acetyltransf_1 PF00583.25 KOO34516.1 - 0.089 13.0 0.0 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Tfb5 PF06331.12 KOO34518.1 - 2.1e-12 46.8 0.1 2.6e-12 46.5 0.1 1.1 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 G-patch_2 PF12656.7 KOO34519.1 - 4.3e-13 49.2 0.1 4.3e-13 49.2 0.1 2.1 2 0 0 2 2 2 1 G-patch domain KOW PF00467.29 KOO34519.1 - 0.0026 17.7 0.0 0.42 10.6 0.0 2.8 2 0 0 2 2 2 2 KOW motif VCBS PF13517.6 KOO34521.1 - 0.0026 18.3 0.7 0.072 13.7 0.3 2.7 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PSI PF01437.25 KOO34521.1 - 0.011 16.2 22.6 0.12 12.9 11.8 2.8 2 0 0 2 2 2 0 Plexin repeat Methyltransf_16 PF10294.9 KOO34522.1 - 2e-17 63.5 0.0 8.1e-14 51.7 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 KOO34522.1 - 8.7e-05 22.4 0.0 0.04 13.8 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 KOO34522.1 - 0.0065 17.2 0.1 5 7.9 0.0 3.3 3 1 0 3 3 3 1 Methyltransferase domain DUF4573 PF15140.6 KOO34522.1 - 0.0082 16.0 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4573) Methyltransf_25 PF13649.6 KOO34522.1 - 0.0086 16.8 0.4 0.22 12.2 0.2 3.1 2 1 0 2 2 2 1 Methyltransferase domain HEAT_PBS PF03130.16 KOO34522.1 - 0.053 14.2 2.5 5.8 7.9 0.1 4.6 2 1 1 3 3 3 0 PBS lyase HEAT-like repeat Abhydrolase_2 PF02230.16 KOO34523.1 - 6.3e-24 85.0 0.0 1.3e-23 84.0 0.0 1.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KOO34523.1 - 1.9e-06 27.5 0.1 0.00047 19.7 0.0 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 KOO34523.1 - 0.00016 21.6 0.7 0.055 13.3 0.2 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 KOO34523.1 - 0.00063 19.4 0.1 0.0009 18.9 0.1 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 KOO34523.1 - 0.0051 16.5 0.0 0.0068 16.1 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) PE-PPE PF08237.11 KOO34523.1 - 0.016 14.7 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain Cutinase PF01083.22 KOO34523.1 - 0.033 14.2 0.2 0.13 12.3 0.1 1.8 1 1 1 2 2 2 0 Cutinase LIP PF03583.14 KOO34523.1 - 0.094 12.0 0.2 0.2 11.0 0.2 1.5 1 0 0 1 1 1 0 Secretory lipase EF-hand_7 PF13499.6 KOO34524.1 - 2.3e-11 44.0 0.4 5.2e-11 42.8 0.4 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO34524.1 - 4.1e-07 29.4 0.8 0.0036 17.1 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO34524.1 - 3.5e-05 23.1 3.4 0.017 14.6 0.1 3.9 3 1 1 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO34524.1 - 0.00019 21.2 2.1 0.00097 18.9 0.1 3.0 2 1 2 4 4 4 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO34524.1 - 0.00038 20.7 0.0 0.0006 20.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain CobN-Mg_chel PF02514.16 KOO34524.1 - 0.0071 14.2 0.0 0.0071 14.2 0.0 1.0 1 0 0 1 1 1 1 CobN/Magnesium Chelatase EF-hand_5 PF13202.6 KOO34524.1 - 0.028 13.9 6.1 1.2 8.8 0.1 3.9 4 0 0 4 4 4 0 EF hand UPF0154 PF03672.13 KOO34524.1 - 0.029 14.4 0.0 0.064 13.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) PRESAN PF09687.10 KOO34524.1 - 0.053 14.1 0.0 0.087 13.4 0.0 1.3 1 0 0 1 1 1 0 Plasmodium RESA N-terminal Cro PF09048.10 KOO34524.1 - 0.071 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Cro Mg_trans_NIPA PF05653.14 KOO34525.1 - 8.6e-23 80.9 12.9 1.3e-22 80.3 12.9 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA BRO1 PF03097.18 KOO34526.1 - 2.9e-58 197.6 0.9 3.9e-58 197.1 0.9 1.1 1 0 0 1 1 1 1 BRO1-like domain UBA PF00627.31 KOO34526.1 - 6.8e-05 22.7 0.2 6.8e-05 22.7 0.2 2.0 2 0 0 2 2 2 1 UBA/TS-N domain UIM PF02809.20 KOO34526.1 - 0.059 13.3 2.0 0.25 11.4 2.0 2.2 1 0 0 1 1 1 0 Ubiquitin interaction motif IQ PF00612.27 KOO34527.1 - 0.00055 19.5 0.0 0.0015 18.2 0.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Tox-HDC PF15656.6 KOO34527.1 - 0.19 11.9 0.0 1 9.5 0.0 1.9 2 0 0 2 2 2 0 Toxin with a H, D/N and C signature RVT_2 PF07727.14 KOO34528.1 - 1.1e-09 38.3 0.0 1.8e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TUDOR_5 PF18359.1 KOO34528.1 - 0.0019 17.8 0.0 0.0043 16.7 0.0 1.5 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 TonB_C PF03544.14 KOO34528.1 - 0.1 13.1 0.0 0.4 11.2 0.0 2.0 2 0 0 2 2 2 0 Gram-negative bacterial TonB protein C-terminal Arm PF00514.23 KOO34529.1 - 2.2e-43 145.0 29.6 1.9e-07 30.9 0.1 10.5 10 1 1 11 11 11 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO34529.1 - 3.1e-07 30.7 38.2 0.0011 19.3 5.2 6.8 2 2 5 7 7 7 4 HEAT repeats V-ATPase_H_N PF03224.14 KOO34529.1 - 6.2e-07 29.0 0.0 0.002 17.5 0.0 2.5 2 1 1 3 3 3 2 V-ATPase subunit H Atx10homo_assoc PF09759.9 KOO34529.1 - 2.9e-05 24.0 0.0 0.012 15.6 0.0 3.4 2 1 1 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Neurochondrin PF05536.11 KOO34529.1 - 0.00062 18.3 2.5 0.0033 15.9 0.1 2.6 3 0 0 3 3 3 1 Neurochondrin HEAT PF02985.22 KOO34529.1 - 0.073 13.4 15.4 37 4.9 0.1 8.4 9 0 0 9 9 9 0 HEAT repeat UNC45-central PF11701.8 KOO34529.1 - 0.12 12.4 0.2 5.6 6.9 0.0 3.4 2 1 1 3 3 3 0 Myosin-binding striated muscle assembly central TPR_12 PF13424.6 KOO34531.1 - 7.3e-91 298.5 47.5 4.4e-17 62.1 3.8 6.9 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 KOO34531.1 - 3.8e-82 268.2 32.6 1.4e-11 43.9 0.1 8.2 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34531.1 - 5.7e-24 82.9 0.7 0.0054 16.5 0.0 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 KOO34531.1 - 1.1e-17 62.7 15.2 0.025 14.6 0.3 7.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOO34531.1 - 1.7e-16 59.3 5.3 0.17 12.4 0.0 7.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO34531.1 - 6.1e-14 52.3 12.3 0.00085 19.8 0.6 5.7 1 1 4 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO34531.1 - 1.2e-13 51.5 8.3 0.12 13.0 0.0 6.8 3 1 3 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO34531.1 - 4.6e-13 48.2 5.6 0.15 12.2 0.0 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO34531.1 - 3.8e-12 45.9 15.0 0.17 12.8 0.6 7.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_4 PF07721.14 KOO34531.1 - 1.2e-11 44.0 6.4 0.2 12.4 0.0 7.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO34531.1 - 3.4e-11 42.4 4.7 0.61 10.4 0.0 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat PPR PF01535.20 KOO34531.1 - 2.2e-09 36.9 2.9 6.3 7.3 0.0 7.3 7 0 0 7 7 7 0 PPR repeat TPR_5 PF12688.7 KOO34531.1 - 7.4e-07 29.4 17.0 0.00071 19.8 3.7 4.0 1 1 3 4 4 4 3 Tetratrico peptide repeat DUF3856 PF12968.7 KOO34531.1 - 7.4e-06 26.1 12.5 0.14 12.3 2.3 5.8 1 1 2 5 5 5 2 Domain of Unknown Function (DUF3856) ANAPC3 PF12895.7 KOO34531.1 - 1.2e-05 25.4 1.5 0.22 11.8 0.1 4.3 2 2 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Gly_radical PF01228.21 KOO34531.1 - 2.5e-05 24.8 2.0 1.2 9.7 0.1 3.9 3 1 1 4 4 3 1 Glycine radical TPR_20 PF14561.6 KOO34531.1 - 8e-05 22.9 18.3 1.7 9.0 1.1 6.6 1 1 2 4 4 4 1 Tetratricopeptide repeat TMEM251 PF15190.6 KOO34531.1 - 0.0003 20.7 0.6 0.00087 19.2 0.6 1.8 1 0 0 1 1 1 1 Transmembrane protein 251 TPR_6 PF13174.6 KOO34531.1 - 0.0094 16.5 12.5 4.2 8.2 0.1 7.3 7 1 0 7 7 7 1 Tetratricopeptide repeat MIT PF04212.18 KOO34531.1 - 0.013 15.6 6.4 4.1 7.5 0.1 4.5 5 1 1 6 6 4 0 MIT (microtubule interacting and transport) domain DIRP PF06584.13 KOO34531.1 - 0.12 12.5 0.1 9.7 6.4 0.0 3.1 2 1 1 3 3 2 0 DIRP DUF4145 PF13643.6 KOO34531.1 - 0.7 10.1 12.0 1.2 9.3 0.3 4.8 3 2 2 5 5 5 0 Domain of unknown function (DUF4145) Fis1_TPR_C PF14853.6 KOO34531.1 - 0.86 9.7 4.7 36 4.5 0.1 4.3 5 0 0 5 5 3 0 Fis1 C-terminal tetratricopeptide repeat SAM_KSR1 PF13543.6 KOO34531.1 - 2.4 8.3 7.2 25 5.0 0.1 3.6 2 1 4 6 6 6 0 SAM like domain present in kinase suppressor RAS 1 AIP3 PF03915.13 KOO34531.1 - 3.3 6.7 12.4 0.17 10.9 0.8 2.7 2 1 1 3 3 3 0 Actin interacting protein 3 Spectrin PF00435.21 KOO34531.1 - 4.1 7.9 18.3 0.34 11.4 0.7 4.1 3 1 1 4 4 4 0 Spectrin repeat LapA_dom PF06305.11 KOO34531.1 - 4.7 7.1 9.8 17 5.4 1.4 3.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SLX9 PF15341.6 KOO34531.1 - 7.8 6.9 19.4 12 6.3 0.3 5.6 2 1 2 4 4 4 0 Ribosome biogenesis protein SLX9 Gln_amidase PF15644.6 KOO34531.1 - 8.3 7.5 6.6 4.6 8.3 0.3 3.2 2 1 1 4 4 3 0 Papain fold toxin 1, glutamine deamidase DUF3825 PF12873.7 KOO34532.1 - 0.0087 15.5 0.1 0.037 13.5 0.0 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3825) LRR_6 PF13516.6 KOO34533.1 - 1.6e-22 77.6 4.2 0.0001 22.1 0.0 4.3 4 0 0 4 4 4 4 Leucine Rich repeat LRR_8 PF13855.6 KOO34533.1 - 5.5e-05 22.8 1.0 3.4 7.5 0.0 3.9 3 1 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 KOO34533.1 - 0.00016 22.0 5.5 1.4 9.5 0.1 3.9 3 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO34533.1 - 0.0013 19.0 0.0 8.2 7.4 0.0 3.8 4 0 0 4 4 4 1 Leucine Rich Repeat FAM25 PF15825.5 KOO34533.1 - 2.6 8.4 5.8 9 6.7 0.6 3.0 2 1 1 3 3 3 0 FAM25 family HR1 PF02185.16 KOO34534.1 - 0.0009 19.3 3.1 0.0009 19.3 3.1 7.9 5 3 3 8 8 8 1 Hr1 repeat PI3K_P85_iSH2 PF16454.5 KOO34534.1 - 0.0039 16.8 4.9 0.0039 16.8 4.9 4.3 2 1 0 3 3 3 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Pox_A_type_inc PF04508.12 KOO34534.1 - 0.8 9.7 6.8 0.64 10.0 0.1 4.1 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat RNA_pol_Rpb1_1 PF04997.12 KOO34536.1 - 2.4e-31 109.2 0.0 3.7e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 SlyX PF04102.12 KOO34536.1 - 0.024 15.3 3.8 0.024 15.3 3.8 4.8 3 1 0 4 4 4 0 SlyX NPV_P10 PF05531.12 KOO34536.1 - 1.5 9.3 6.6 7.2 7.2 0.3 3.7 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Lipase_GDSL_2 PF13472.6 KOO34537.1 - 4.5e-23 82.6 0.4 7.9e-23 81.8 0.4 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KOO34537.1 - 6.4e-07 29.5 0.0 4.3e-06 26.8 0.0 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Aminotran_1_2 PF00155.21 KOO34538.1 - 1.8e-87 293.9 0.0 3.2e-52 177.9 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class I and II PqiA PF04403.13 KOO34538.1 - 2.5e-08 33.9 7.3 0.001 18.9 1.4 2.8 2 0 0 2 2 2 2 Paraquat-inducible protein A PAP2 PF01569.21 KOO34538.1 - 9.1e-07 28.7 1.7 9.1e-07 28.7 1.7 2.6 3 0 0 3 3 3 1 PAP2 superfamily Pkinase PF00069.25 KOO34539.1 - 1.4e-45 155.7 0.0 6.9e-28 97.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34539.1 - 3.7e-21 75.6 0.1 5.3e-11 42.3 0.3 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOO34539.1 - 0.0029 17.0 0.0 2.1 7.6 0.0 2.5 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 KOO34539.1 - 0.035 12.9 0.0 0.07 11.9 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase MHYT PF03707.16 KOO34540.1 - 6 7.1 12.2 6 7.1 8.4 2.2 1 1 1 2 2 2 0 Bacterial signalling protein N terminal repeat Galactosyl_T PF01762.21 KOO34541.1 - 3.2e-10 40.1 0.0 6.4e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 KOO34541.1 - 0.09 12.2 0.1 0.15 11.4 0.1 1.4 1 1 0 1 1 1 0 Fringe-like zf-C2H2_11 PF16622.5 KOO34541.1 - 1.4 8.8 4.0 3 7.7 4.0 1.5 1 0 0 1 1 1 0 zinc-finger C2H2-type DUF4698 PF15769.5 KOO34542.1 - 0.027 13.5 0.3 0.04 13.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) GSH-S_N PF02951.14 KOO34542.1 - 0.44 10.7 2.1 27 4.9 0.0 2.5 1 1 1 2 2 2 0 Prokaryotic glutathione synthetase, N-terminal domain Gene66 PF02053.15 KOO34544.1 - 0.013 15.2 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Gene 66 (IR5) protein Imm49 PF15575.6 KOO34544.1 - 0.033 13.9 0.0 0.097 12.4 0.0 1.7 2 0 0 2 2 2 0 Immunity protein 49 Pkinase PF00069.25 KOO34545.1 - 3.7e-06 26.5 0.0 5.8e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain KA1 PF02149.19 KOO34545.1 - 0.022 14.6 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Kinase associated domain 1 Pkinase_Tyr PF07714.17 KOO34545.1 - 0.034 13.4 0.0 0.051 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase TMEM189_B_dmain PF10520.9 KOO34546.1 - 1.5e-31 109.8 2.4 2.8e-31 109.0 0.1 2.0 2 0 0 2 2 2 1 B domain of TMEM189, localisation domain FA_hydroxylase PF04116.13 KOO34546.1 - 0.029 14.7 1.7 0.053 13.9 1.7 1.3 1 0 0 1 1 1 0 Fatty acid hydroxylase superfamily LRR_6 PF13516.6 KOO34547.1 - 7.9e-13 47.4 20.5 0.00044 20.1 0.4 7.4 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.33 KOO34547.1 - 4.4e-05 23.5 1.4 13 6.8 0.3 5.6 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO34547.1 - 0.00097 18.8 3.5 12 5.7 0.0 5.0 6 0 0 6 6 6 2 Leucine rich repeat Skp1 PF01466.19 KOO34547.1 - 0.0017 18.4 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_4 PF12799.7 KOO34547.1 - 0.0061 16.9 4.0 26 5.4 0.7 4.2 3 1 0 3 3 3 1 Leucine Rich repeats (2 copies) MAGE PF01454.19 KOO34548.1 - 3.2e-25 89.1 0.0 4.5e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 MAGE family DUF1940 PF09155.10 KOO34549.1 - 0.05 13.7 0.4 0.11 12.6 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1940) Pkinase PF00069.25 KOO34550.1 - 3.2e-65 220.1 0.0 4.4e-65 219.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34550.1 - 3.3e-26 92.1 0.0 4.8e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 KOO34550.1 - 2e-19 69.8 0.6 1.9e-05 25.0 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO34550.1 - 1.2e-16 59.1 2.7 1.9e-05 24.2 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KOO34550.1 - 1.6e-16 58.5 0.9 5.1e-06 25.6 0.0 3.7 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOO34550.1 - 3.7e-15 55.5 1.3 1.7e-05 24.5 0.1 4.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO34550.1 - 2.9e-10 39.2 2.6 0.00027 20.3 0.2 3.4 3 0 0 3 3 3 2 EF hand Pkinase_fungal PF17667.1 KOO34550.1 - 1.7e-05 23.8 0.0 3.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO34550.1 - 6.9e-05 22.3 0.0 0.00014 21.3 0.0 1.5 1 1 0 1 1 1 1 Kinase-like EF-hand_11 PF08976.11 KOO34550.1 - 0.00031 21.6 0.0 0.00072 20.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain Kdo PF06293.14 KOO34550.1 - 0.0027 17.1 0.0 0.0046 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF5580 PF17743.1 KOO34550.1 - 0.013 14.1 0.1 0.018 13.6 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) APH PF01636.23 KOO34550.1 - 0.016 15.2 0.7 0.048 13.6 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Sp38 PF07354.12 KOO34550.1 - 0.04 13.4 0.0 0.073 12.5 0.0 1.3 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) SPARC_Ca_bdg PF10591.9 KOO34550.1 - 0.14 12.5 0.2 2.6 8.4 0.0 2.5 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Ank_2 PF12796.7 KOO34551.1 - 5.4e-23 81.4 3.6 1.7e-10 41.3 0.0 2.9 3 0 0 3 3 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34551.1 - 4.5e-22 78.1 3.3 8.6e-08 32.6 0.0 4.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO34551.1 - 1.4e-16 60.1 1.5 0.00013 22.3 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO34551.1 - 8.1e-13 48.3 0.4 6.9e-05 23.0 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34551.1 - 5.9e-11 41.6 0.3 0.012 16.1 0.0 5.3 5 0 0 5 5 4 2 Ankyrin repeat TPR_1 PF00515.28 KOO34551.1 - 3.3e-06 26.7 0.2 0.2 11.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO34551.1 - 0.00049 20.0 3.8 2.5 8.4 0.1 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO34551.1 - 0.0029 17.2 0.1 0.048 13.4 0.0 2.6 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.6 KOO34551.1 - 0.042 14.7 14.1 9.2 7.4 0.0 5.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO34551.1 - 0.059 13.8 0.5 2.1 8.9 0.1 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat MAS20 PF02064.15 KOO34551.1 - 0.16 12.1 0.9 0.52 10.4 0.9 1.9 1 0 0 1 1 1 0 MAS20 protein import receptor FAM176 PF14851.6 KOO34551.1 - 3.6 7.3 5.8 6.8 6.3 5.8 1.4 1 0 0 1 1 1 0 FAM176 family Nha1_C PF08619.10 KOO34551.1 - 8.6 5.4 12.0 13 4.8 12.0 1.2 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus EF-hand_1 PF00036.32 KOO34552.1 - 2.8e-15 54.6 2.0 2.2e-06 26.8 0.3 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO34552.1 - 4.9e-15 55.7 0.1 8.9e-15 54.9 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO34552.1 - 2.2e-13 48.9 2.9 1.3e-07 31.0 0.0 3.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KOO34552.1 - 2.3e-12 46.6 0.1 3.4e-07 30.0 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO34552.1 - 1.6e-11 43.2 5.3 6.3e-06 25.5 0.1 2.7 3 0 0 3 3 3 2 EF hand Peptidase_C14 PF00656.22 KOO34552.1 - 0.018 15.0 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Caspase domain YqzH PF14164.6 KOO34552.1 - 0.18 11.9 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 YqzH-like protein Asp_Arg_Hydrox PF05118.15 KOO34553.1 - 1.7e-19 70.2 0.3 4.5e-19 68.8 0.0 1.8 2 0 0 2 2 2 1 Aspartyl/Asparaginyl beta-hydroxylase TPR_8 PF13181.6 KOO34553.1 - 0.0021 18.1 0.1 0.12 12.6 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO34553.1 - 0.012 15.6 0.4 0.7 10.2 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34553.1 - 0.016 15.0 0.0 0.45 10.4 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_6 PF13516.6 KOO34554.1 - 4.4e-11 41.9 8.7 0.00082 19.2 0.3 5.8 6 0 0 6 6 6 3 Leucine Rich repeat LRR_1 PF00560.33 KOO34554.1 - 0.0041 17.5 0.1 37 5.4 0.1 3.9 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO34554.1 - 0.0063 16.2 0.3 13 5.7 0.1 3.5 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 KOO34554.1 - 0.017 15.6 3.0 6.8 7.3 0.7 3.5 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) DprA_WH PF17782.1 KOO34554.1 - 0.069 13.3 1.3 11 6.2 0.0 2.8 3 0 0 3 3 3 0 DprA winged helix domain DUF4523 PF15023.6 KOO34555.1 - 0.049 13.4 0.0 0.14 12.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) WD40 PF00400.32 KOO34559.1 - 3.7e-79 258.6 36.5 7.3e-09 36.1 0.3 10.7 10 0 0 10 10 10 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO34559.1 - 1.2e-23 83.2 6.8 0.0032 17.7 0.0 8.4 3 1 5 9 9 8 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO34559.1 - 2e-22 79.6 12.1 0.0024 16.9 0.0 8.2 1 1 7 8 8 8 8 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO34559.1 - 2.4e-17 62.4 2.1 1.1 9.3 0.0 8.6 8 0 0 8 8 8 3 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 KOO34559.1 - 1.6e-08 34.2 8.6 0.81 9.0 0.0 6.2 1 1 7 8 8 8 4 Neuroblastoma-amplified sequence, N terminal NACHT PF05729.12 KOO34559.1 - 2.8e-08 33.9 0.0 6.1e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Frtz PF11768.8 KOO34559.1 - 5.7e-08 31.5 0.0 1 7.6 0.0 5.0 1 1 5 6 6 6 5 WD repeat-containing and planar cell polarity effector protein Fritz DCX PF03607.17 KOO34559.1 - 2.3e-07 30.8 0.0 4.8 7.4 0.0 7.6 8 0 0 8 8 8 1 Doublecortin AAA_16 PF13191.6 KOO34559.1 - 2.9e-07 31.0 0.0 7.3e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain WD40_like PF17005.5 KOO34559.1 - 1.9e-05 24.2 1.7 0.29 10.4 0.0 4.1 2 1 2 4 4 4 2 WD40-like domain APAF1_C PF17908.1 KOO34559.1 - 2.1e-05 24.5 0.0 5.8e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 APAF-1 helical domain KAP_NTPase PF07693.14 KOO34559.1 - 0.0025 17.1 0.0 0.63 9.2 0.0 2.4 2 0 0 2 2 2 2 KAP family P-loop domain WD40_3 PF15911.5 KOO34559.1 - 0.053 13.5 2.0 2e+02 2.1 0.0 5.8 8 0 0 8 8 8 0 WD domain, G-beta repeat Utp8 PF10395.9 KOO34559.1 - 0.099 11.1 1.1 7.4 4.9 0.1 2.7 2 1 1 3 3 3 0 Utp8 family 3-dmu-9_3-mt PF06983.13 KOO34559.1 - 0.16 12.5 0.2 88 3.7 0.0 4.2 3 1 2 5 5 5 0 3-demethylubiquinone-9 3-methyltransferase dsrm PF00035.26 KOO34559.1 - 2.7 8.8 5.4 22 5.8 0.1 4.7 6 0 0 6 6 5 0 Double-stranded RNA binding motif Lin-8 PF03353.15 KOO34560.1 - 0.011 15.4 3.2 0.3 10.6 0.3 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MDM10 PF12519.8 KOO34560.1 - 2.6 6.8 3.8 0.83 8.5 0.1 1.8 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 EF-hand_6 PF13405.6 KOO34561.1 - 8.7e-07 28.4 0.5 0.0044 16.9 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO34561.1 - 0.00038 20.9 0.3 0.013 15.9 0.3 2.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO34561.1 - 0.0034 16.8 0.0 0.0093 15.5 0.0 1.8 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO34561.1 - 0.0076 15.7 0.1 0.017 14.6 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO34561.1 - 0.015 15.1 0.1 0.048 13.5 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_like PF09279.11 KOO34561.1 - 0.15 12.6 1.5 3.3 8.3 0.1 2.6 2 1 1 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like UBA_4 PF14555.6 KOO34563.1 - 5.5e-05 22.9 0.0 8.6e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 UBA-like domain UBA PF00627.31 KOO34563.1 - 0.00015 21.6 0.0 0.00025 20.9 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain DUF1296 PF06972.11 KOO34563.1 - 0.11 12.6 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) ERG4_ERG24 PF01222.17 KOO34564.1 - 1.8e-43 148.9 0.0 4.7e-43 147.5 0.0 1.5 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 KOO34564.1 - 0.019 14.5 0.1 0.032 13.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) PRIMA1 PF16101.5 KOO34564.1 - 1.7 8.7 6.3 4.8 7.3 6.3 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 fn3 PF00041.21 KOO34565.1 - 1.6e-08 34.8 0.1 2.7e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KOO34565.1 - 0.025 15.2 0.3 0.12 13.0 0.0 1.9 1 1 1 2 2 2 0 Purple acid Phosphatase, N-terminal domain ADPrib_exo_Tox PF03496.14 KOO34567.1 - 4.6e-05 22.8 0.0 0.0073 15.7 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO34567.1 - 0.00034 20.0 0.0 0.00081 18.7 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase KxDL PF10241.9 KOO34567.1 - 0.077 13.3 0.2 0.25 11.7 0.2 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein U-box PF04564.15 KOO34568.1 - 9.4e-12 44.9 0.1 2.5e-11 43.6 0.0 1.7 2 0 0 2 2 2 1 U-box domain Sel1 PF08238.12 KOO34568.1 - 2.5e-07 31.2 9.6 0.0048 17.5 1.0 3.5 3 0 0 3 3 3 2 Sel1 repeat zf-Nse PF11789.8 KOO34568.1 - 0.001 18.8 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO34568.1 - 0.004 17.2 0.0 0.0085 16.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein LRR_5 PF13306.6 KOO34569.1 - 4.1e-30 104.4 0.5 4.4e-30 104.3 0.5 1.0 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO34569.1 - 0.003 17.3 0.0 0.12 12.1 0.0 2.3 1 1 1 2 2 2 1 Leucine rich repeat DUF4072 PF13284.6 KOO34569.1 - 0.017 15.5 0.1 1.6 9.2 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4072) Sel1 PF08238.12 KOO34570.1 - 1.8e-12 47.5 13.7 1.7e-07 31.7 1.8 3.8 3 0 0 3 3 3 3 Sel1 repeat U-box PF04564.15 KOO34570.1 - 5.4e-12 45.7 0.1 1.6e-11 44.2 0.0 1.8 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 KOO34570.1 - 0.00054 19.7 0.0 0.0018 18.0 0.0 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO34570.1 - 0.0051 16.9 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein TPR_6 PF13174.6 KOO34570.1 - 0.065 13.9 1.5 0.39 11.5 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Ank_3 PF13606.6 KOO34572.1 - 1.3e-09 37.5 1.1 0.00024 21.3 0.0 4.5 3 0 0 3 3 3 2 Ankyrin repeat PfkB PF00294.24 KOO34572.1 - 1.4e-09 37.7 1.8 4.4e-05 22.9 0.0 3.1 3 0 0 3 3 3 2 pfkB family carbohydrate kinase Ank_2 PF12796.7 KOO34572.1 - 1.6e-09 38.2 1.6 3.4e-09 37.2 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34572.1 - 5.6e-05 23.6 1.7 0.00013 22.4 0.3 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO34572.1 - 6.4e-05 23.2 8.0 0.0061 17.0 0.1 4.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 KOO34572.1 - 0.002 18.4 0.1 0.031 14.6 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) TIR_2 PF13676.6 KOO34572.1 - 0.02 15.5 0.2 1.2 9.8 0.1 2.6 2 0 0 2 2 2 0 TIR domain TIR_2 PF13676.6 KOO34573.1 - 2.7e-09 37.7 0.0 6.7e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 TIR domain EF-hand_5 PF13202.6 KOO34573.1 - 7.5e-06 25.2 0.0 1.8e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 EF hand Methyltransf_25 PF13649.6 KOO34573.1 - 9.8e-06 26.2 0.2 6e-05 23.7 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO34573.1 - 1.8e-05 25.3 0.8 0.00016 22.2 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain EF-hand_1 PF00036.32 KOO34573.1 - 0.00021 20.6 0.0 0.0005 19.4 0.0 1.6 1 0 0 1 1 1 1 EF hand NACHT PF05729.12 KOO34573.1 - 0.00026 20.9 0.0 0.0014 18.5 0.0 2.1 1 1 0 1 1 1 1 NACHT domain RrnaAD PF00398.20 KOO34573.1 - 0.00047 19.3 0.0 0.00077 18.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase EF-hand_6 PF13405.6 KOO34573.1 - 0.00066 19.4 0.1 0.0023 17.7 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain TIR PF01582.20 KOO34573.1 - 0.0031 17.3 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 TIR domain MTS PF05175.14 KOO34573.1 - 0.0048 16.5 0.0 0.014 15.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain AAA_22 PF13401.6 KOO34573.1 - 0.007 16.6 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOO34573.1 - 0.0086 16.6 0.0 0.017 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO34573.1 - 0.0092 16.4 0.0 0.026 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain Methyltransf_12 PF08242.12 KOO34573.1 - 0.012 16.3 0.0 0.038 14.7 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 KOO34573.1 - 0.018 14.9 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain AAA_28 PF13521.6 KOO34573.1 - 0.022 15.0 0.0 0.05 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain EF-hand_7 PF13499.6 KOO34573.1 - 0.027 14.9 0.0 0.078 13.4 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair AAA_29 PF13555.6 KOO34573.1 - 0.04 13.7 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 KOO34573.1 - 0.045 13.5 0.0 0.08 12.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 KOO34573.1 - 0.15 12.2 0.1 0.73 10.0 0.1 2.1 2 0 0 2 2 2 0 AAA domain RPGR1_C PF18111.1 KOO34574.1 - 5.7e-11 42.6 0.0 7.3e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Retinitis pigmentosa G-protein regulator interacting C-terminal UBA PF00627.31 KOO34574.1 - 4e-05 23.4 1.3 5.6e-05 23.0 0.1 1.9 2 0 0 2 2 2 1 UBA/TS-N domain HOIP-UBA PF16678.5 KOO34574.1 - 0.026 14.5 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair CUE PF02845.16 KOO34574.1 - 0.026 14.2 0.1 0.05 13.3 0.1 1.5 1 0 0 1 1 1 0 CUE domain BSD PF03909.17 KOO34575.1 - 3.4e-06 27.0 0.0 6.4e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 BSD domain Maf PF02545.14 KOO34576.1 - 1.2e-26 93.5 0.0 1.4e-26 93.3 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein FUSC PF04632.12 KOO34577.1 - 0.029 12.9 8.3 0.032 12.8 8.3 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Pro_isomerase PF00160.21 KOO34578.1 - 2.2e-29 102.7 0.0 2.9e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PDZ PF00595.24 KOO34579.1 - 1.3e-05 25.4 3.0 1.6e-05 25.2 0.4 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KOO34579.1 - 0.00036 20.3 0.9 0.0014 18.4 0.9 2.1 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO34579.1 - 0.062 13.6 0.7 0.23 11.8 0.3 2.3 2 0 0 2 2 2 0 PDZ domain PH_12 PF16457.5 KOO34579.1 - 0.083 13.4 1.0 5.3 7.6 0.1 3.2 2 1 0 2 2 2 0 Pleckstrin homology domain ST7 PF04184.12 KOO34579.1 - 0.32 9.4 2.6 0.52 8.7 1.7 1.6 1 1 1 2 2 2 0 ST7 protein EF-hand_1 PF00036.32 KOO34580.1 - 4e-25 85.4 6.9 6.8e-06 25.3 0.3 5.6 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 KOO34580.1 - 3.3e-21 75.5 6.0 7.4e-09 35.9 0.3 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO34580.1 - 9.8e-20 68.8 10.4 0.00021 21.0 0.0 5.7 5 0 0 5 5 5 5 EF-hand domain EF-hand_8 PF13833.6 KOO34580.1 - 1e-19 70.1 7.3 7.5e-07 28.9 0.1 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO34580.1 - 3.6e-17 61.0 10.1 0.00022 20.6 0.2 4.9 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 KOO34580.1 - 0.00025 21.3 0.1 0.17 12.2 0.0 2.7 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO34580.1 - 0.0029 17.5 4.2 0.35 10.8 0.2 3.4 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 KOO34580.1 - 0.0072 17.2 0.0 0.87 10.5 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_9 PF14658.6 KOO34580.1 - 0.024 15.0 0.5 13 6.2 0.0 3.9 4 1 0 4 4 4 0 EF-hand domain PIG-P PF08510.12 KOO34582.1 - 1.1e-08 35.0 0.1 1.3e-08 34.8 0.1 1.1 1 0 0 1 1 1 1 PIG-P TPR_19 PF14559.6 KOO34583.1 - 1.7 9.2 16.9 0.18 12.3 1.5 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat CRAL_TRIO PF00650.20 KOO34584.1 - 0.037 13.7 0.0 0.059 13.1 0.0 1.3 1 0 0 1 1 1 0 CRAL/TRIO domain Esterase PF00756.20 KOO34585.1 - 3e-55 187.6 0.0 3.4e-55 187.4 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 KOO34585.1 - 0.00013 21.5 0.1 0.0013 18.2 0.0 2.0 2 0 0 2 2 2 1 Esterase PHB depolymerase Hydrolase_4 PF12146.8 KOO34585.1 - 0.00026 20.4 0.1 0.00085 18.7 0.0 1.8 2 1 0 2 2 2 1 Serine aminopeptidase, S33 KH_1 PF00013.29 KOO34586.1 - 3.1e-35 119.8 0.0 2.3e-07 30.6 0.0 6.2 6 0 0 6 6 6 6 KH domain KH_2 PF07650.17 KOO34586.1 - 0.00025 20.8 0.0 1.4 8.8 0.0 4.7 4 1 1 5 5 5 1 KH domain KH_4 PF13083.6 KOO34586.1 - 0.0014 18.5 0.1 27 4.7 0.0 4.2 4 0 0 4 4 4 2 KH domain PIF1 PF05970.14 KOO34587.1 - 1.1e-29 103.7 0.0 3.2e-20 72.6 0.0 2.5 2 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 KOO34587.1 - 6.4e-21 74.9 0.0 2e-17 63.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KOO34587.1 - 4.3e-16 59.6 0.0 1.3e-15 58.0 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KOO34587.1 - 4.7e-05 23.3 0.0 0.0099 15.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOO34587.1 - 0.00031 21.0 0.0 0.0017 18.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 KOO34587.1 - 0.0005 20.0 0.9 0.048 13.5 0.6 2.9 2 1 0 2 2 2 1 Helicase Viral_helicase1 PF01443.18 KOO34587.1 - 0.004 16.9 0.0 0.0072 16.1 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 KOO34587.1 - 0.0052 16.7 0.1 0.015 15.2 0.0 1.8 3 0 0 3 3 3 1 NTPase NACHT PF05729.12 KOO34587.1 - 0.0096 15.9 0.1 0.035 14.0 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_5 PF07728.14 KOO34587.1 - 0.01 15.8 0.2 0.046 13.7 0.2 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOO34587.1 - 0.026 14.9 0.1 0.068 13.5 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 KOO34587.1 - 0.031 14.7 0.0 0.054 13.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.9 KOO34587.1 - 0.1 11.5 0.1 0.17 10.8 0.1 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF2075 PF09848.9 KOO34587.1 - 0.1 11.8 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MeaB PF03308.16 KOO34587.1 - 0.11 11.4 0.1 0.19 10.7 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Nucleotid_trans PF03407.16 KOO34588.1 - 7.6e-29 101.2 0.0 2.1e-28 99.7 0.0 1.7 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ARL2_Bind_BART PF11527.8 KOO34589.1 - 3.8e-14 52.8 0.0 4.7e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART PBP1_TM PF14812.6 KOO34590.1 - 1.2 9.5 5.5 1 9.8 2.6 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BRO1 PF03097.18 KOO34591.1 - 4.7e-44 150.8 0.0 7.7e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KOO34591.1 - 1.1e-19 70.9 10.2 1.1e-19 70.9 10.2 2.1 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Pkinase_Tyr PF07714.17 KOO34592.1 - 1e-26 93.8 0.0 1.3e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO34592.1 - 8.4e-26 90.9 0.0 1.3e-25 90.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO34592.1 - 0.001 19.1 0.1 0.0018 18.2 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO34592.1 - 0.16 10.7 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase 2OG-FeII_Oxy_4 PF13661.6 KOO34593.1 - 2e-14 54.0 0.9 6.1e-14 52.5 0.9 1.9 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 KOO34593.1 - 3.3e-09 37.5 1.6 7.1e-09 36.4 1.6 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pkinase_Tyr PF07714.17 KOO34593.1 - 0.0017 17.7 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ofd1_CTDD PF10637.9 KOO34593.1 - 0.0035 16.7 0.0 0.14 11.4 0.0 2.4 1 1 0 1 1 1 1 Oxoglutarate and iron-dependent oxygenase degradation C-term DUF4525 PF15027.6 KOO34594.1 - 0.051 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) Peptidase_M15_2 PF05951.13 KOO34594.1 - 0.068 12.8 0.0 0.71 9.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) LVIVD PF08309.11 KOO34595.1 - 5.7e-21 73.6 18.1 8.6e-09 34.6 1.7 3.6 3 0 0 3 3 3 3 LVIVD repeat Tmemb_40 PF10160.9 KOO34595.1 - 0.0045 16.5 0.2 0.0079 15.7 0.2 1.3 1 0 0 1 1 1 1 Predicted membrane protein GCV_T_C PF08669.11 KOO34595.1 - 0.025 14.5 0.1 0.025 14.5 0.1 2.7 3 1 0 3 3 3 0 Glycine cleavage T-protein C-terminal barrel domain PSCyt3 PF07627.11 KOO34595.1 - 0.11 12.7 0.0 12 6.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1588) Chitin_bind_4 PF00379.23 KOO34595.1 - 0.25 11.9 6.3 31 5.2 0.0 3.8 4 0 0 4 4 4 0 Insect cuticle protein Ank_2 PF12796.7 KOO34596.1 - 4.1e-07 30.5 0.0 7.3e-07 29.7 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34596.1 - 5.5e-07 30.0 0.1 0.0019 18.8 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO34596.1 - 3.9e-06 27.0 0.0 0.0023 18.2 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34596.1 - 3.4e-05 23.9 0.0 1.5 9.7 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KOO34596.1 - 0.0011 19.3 0.0 0.55 10.8 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat HTH_7 PF02796.15 KOO34596.1 - 0.065 13.3 0.0 0.2 11.8 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase VCBS PF13517.6 KOO34597.1 - 5.4e-94 308.8 129.5 1.8e-12 47.6 5.5 11.5 2 1 9 11 11 11 11 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO34597.1 - 6.5e-47 157.3 122.5 0.00018 21.5 1.1 13.8 13 0 0 13 13 13 13 FG-GAP repeat Ephrin_rec_like PF07699.13 KOO34597.1 - 3.2e-44 148.5 214.8 2e-07 30.6 2.1 21.4 8 4 14 24 24 24 19 Putative ephrin-receptor like Dockerin_1 PF00404.18 KOO34597.1 - 0.00017 21.7 39.0 39 4.5 0.2 11.3 11 0 0 11 11 11 0 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO34597.1 - 0.00082 18.8 53.1 0.5 9.7 0.3 11.2 5 2 5 11 11 11 6 Insecticide toxin TcdB middle/N-terminal region Glyco_transf_56 PF07429.11 KOO34597.1 - 0.22 10.6 2.0 72 2.3 0.0 5.1 7 0 0 7 7 7 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 Tmemb_14 PF03647.13 KOO34597.1 - 0.45 11.3 3.8 0.17 12.6 0.4 2.1 2 0 0 2 2 2 0 Transmembrane proteins 14C Methyltransf_21 PF05050.12 KOO34598.1 - 1.3e-09 38.3 0.0 2.2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain HrpB1_HrpK PF09613.10 KOO34599.1 - 0.036 13.7 1.0 2.3 7.9 0.0 2.9 3 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) OTU PF02338.19 KOO34600.1 - 4.6e-05 23.9 0.0 0.0003 21.3 0.0 2.2 2 0 0 2 2 2 1 OTU-like cysteine protease Methyltransf_25 PF13649.6 KOO34601.1 - 1.4e-11 44.9 0.0 2.4e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO34601.1 - 5.7e-07 29.5 0.0 8.2e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO34601.1 - 1.3e-06 29.0 0.0 2.1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOO34601.1 - 5.1e-06 26.0 0.0 1.2e-05 24.8 0.0 1.5 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 KOO34601.1 - 0.00045 20.9 0.0 0.00071 20.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO34601.1 - 0.00057 19.7 0.0 0.00078 19.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO34601.1 - 0.0013 18.5 0.0 0.0018 18.1 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 KOO34601.1 - 0.022 14.4 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.14 KOO34601.1 - 0.076 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain MitMem_reg PF13012.6 KOO34602.1 - 1e-22 80.7 0.0 1.7e-22 80.0 0.0 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 KOO34602.1 - 2.5e-18 66.2 0.0 4.2e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Myb_DNA-binding PF00249.31 KOO34604.1 - 2.1e-12 47.0 0.0 4.2e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO34604.1 - 0.007 16.6 1.1 0.018 15.2 0.1 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain SlyX PF04102.12 KOO34604.1 - 0.013 16.1 5.2 0.019 15.6 1.3 2.5 3 0 0 3 3 3 0 SlyX Myb_DNA-bind_7 PF15963.5 KOO34604.1 - 0.023 14.6 0.1 0.051 13.5 0.1 1.5 1 1 0 1 1 1 0 Myb DNA-binding like HrpB7 PF09486.10 KOO34604.1 - 0.14 12.5 6.0 1.2 9.5 3.9 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF641 PF04859.12 KOO34604.1 - 0.18 12.1 1.5 0.35 11.2 1.5 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) UCH PF00443.29 KOO34605.1 - 4.3e-51 173.9 0.0 5.1e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO34605.1 - 5.2e-19 69.0 0.0 4.6e-18 65.9 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 KOO34605.1 - 0.13 11.7 0.0 11 5.4 0.0 2.7 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase SOSSC PF15925.5 KOO34606.1 - 5.4 8.4 6.1 2.6 9.4 1.4 2.6 2 1 0 2 2 2 0 SOSS complex subunit C DnaJ PF00226.31 KOO34607.1 - 1.3e-16 60.5 0.1 2.5e-16 59.6 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Peptidase_C58 PF03543.14 KOO34607.1 - 0.055 13.2 3.0 0.2 11.3 3.0 1.9 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen VESA1_N PF12785.7 KOO34607.1 - 2 7.3 8.9 5 6.0 4.5 2.2 2 0 0 2 2 2 0 Variant erythrocyte surface antigen-1 GAS PF13851.6 KOO34608.1 - 0.024 14.0 0.6 0.024 14.0 0.6 4.5 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding Fungal_TACC PF12709.7 KOO34608.1 - 4.5 7.8 18.9 7.3 7.1 0.1 4.7 3 1 1 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins WD40 PF00400.32 KOO34609.1 - 2.4e-15 56.6 0.0 1.2e-06 29.1 0.0 4.6 4 1 1 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO34609.1 - 1.4e-05 25.3 0.0 0.014 15.6 0.0 3.3 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 KOO34609.1 - 0.015 15.3 0.0 0.061 13.4 0.0 1.9 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region HPS3_N PF14761.6 KOO34609.1 - 0.076 12.5 0.0 0.14 11.7 0.0 1.4 1 1 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Ndufs5 PF10200.9 KOO34610.1 - 0.00033 20.9 0.3 0.00037 20.7 0.3 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa CHCH PF06747.13 KOO34610.1 - 0.001 19.1 0.8 0.0015 18.6 0.8 1.3 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 KOO34610.1 - 0.06 13.4 3.0 0.39 10.8 0.5 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 KOO34610.1 - 0.11 12.8 1.7 0.19 12.0 1.7 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Uds1 PF15456.6 KOO34611.1 - 0.0082 16.3 4.1 0.014 15.6 4.1 1.4 1 1 0 1 1 1 1 Up-regulated During Septation Ion_trans_N PF08412.10 KOO34611.1 - 0.023 14.3 0.0 0.052 13.2 0.0 1.6 1 0 0 1 1 1 0 Ion transport protein N-terminal Bcr-Abl_Oligo PF09036.10 KOO34611.1 - 0.045 13.8 5.1 1.4 9.0 0.6 2.2 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DUF892 PF05974.12 KOO34611.1 - 0.053 13.6 5.8 1 9.4 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF892) Rootletin PF15035.6 KOO34611.1 - 0.1 12.6 10.8 0.5 10.4 1.6 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF2721 PF11026.8 KOO34611.1 - 0.38 10.6 5.4 1.9 8.4 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) ATG16 PF08614.11 KOO34611.1 - 0.39 10.9 14.0 0.11 12.7 2.1 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Snapin_Pallidin PF14712.6 KOO34611.1 - 0.74 10.3 10.0 0.59 10.6 2.4 2.3 2 0 0 2 2 2 0 Snapin/Pallidin Rx_N PF18052.1 KOO34611.1 - 1.9 8.8 7.3 0.33 11.2 1.3 2.1 2 0 0 2 2 2 0 Rx N-terminal domain OmpH PF03938.14 KOO34611.1 - 7.6 6.9 9.3 21 5.4 9.1 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) MORN PF02493.20 KOO34612.1 - 3.7e-20 70.5 15.1 1.1e-07 31.3 0.3 4.2 4 0 0 4 4 4 3 MORN repeat EF-hand_7 PF13499.6 KOO34612.1 - 4.4e-13 49.5 0.3 2.1e-11 44.1 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO34612.1 - 3.7e-11 41.7 8.9 9.3e-06 24.8 0.5 4.0 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 KOO34612.1 - 6.4e-10 38.7 0.5 3e-09 36.6 0.1 2.4 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO34612.1 - 1.6e-08 33.8 7.1 9.8e-05 22.0 0.0 3.7 4 0 0 4 4 3 2 EF-hand domain EF-hand_9 PF14658.6 KOO34612.1 - 1.9e-07 31.3 0.0 5.6e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO34612.1 - 4.3e-05 22.8 0.6 0.21 11.1 0.0 3.0 2 0 0 2 2 2 2 EF hand PDZ PF00595.24 KOO34612.1 - 0.00027 21.2 0.0 0.00051 20.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain EF-hand_4 PF12763.7 KOO34612.1 - 0.00037 20.4 0.0 0.00096 19.1 0.0 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SnoaL_2 PF12680.7 KOO34612.1 - 0.0076 16.9 1.6 0.38 11.4 0.1 3.3 2 1 1 3 3 3 1 SnoaL-like domain PDZ_6 PF17820.1 KOO34612.1 - 0.0083 16.0 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Epimerase PF01370.21 KOO34613.1 - 4.3e-46 157.3 0.0 9.8e-46 156.2 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO34613.1 - 3.9e-27 95.5 0.0 7.7e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KOO34613.1 - 9.5e-11 41.3 0.0 2.8e-09 36.5 0.0 2.5 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 KOO34613.1 - 6.1e-08 32.0 0.0 1.2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KOO34613.1 - 1.2e-07 31.1 0.0 9e-05 21.7 0.0 2.5 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 KOO34613.1 - 1.8e-05 25.0 0.1 0.00022 21.5 0.0 2.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain KIAA1430 PF13879.6 KOO34613.1 - 0.17 12.6 14.9 0.13 13.1 0.7 3.5 2 1 2 4 4 4 0 KIAA1430 homologue Hydrolase_4 PF12146.8 KOO34615.1 - 1.9e-05 24.1 0.0 4.7e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO34615.1 - 0.00066 20.3 4.5 0.00066 20.3 4.5 1.8 1 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO34615.1 - 0.0053 16.4 0.1 0.0096 15.6 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 KOO34615.1 - 0.016 15.0 0.4 0.046 13.6 0.4 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 KOO34615.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative esterase OmpA PF00691.20 KOO34616.1 - 9e-24 83.7 0.0 3.6e-13 49.7 0.0 2.9 2 0 0 2 2 2 2 OmpA family Pilus_CpaD PF09476.10 KOO34616.1 - 0.00056 19.7 2.0 0.017 14.8 0.1 2.8 2 1 0 2 2 2 1 Pilus biogenesis CpaD protein (pilus_cpaD) DUF3394 PF11874.8 KOO34616.1 - 0.043 13.5 0.2 0.15 11.7 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3394) ERM PF00769.19 KOO34616.1 - 0.1 12.4 16.3 0.16 11.7 5.3 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF2203 PF09969.9 KOO34616.1 - 3.7 8.3 9.3 44 4.8 1.0 3.4 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) SNARE_assoc PF09335.11 KOO34618.1 - 1.8e-17 63.9 7.5 1.8e-17 63.9 7.5 1.4 2 0 0 2 2 2 1 SNARE associated Golgi protein SpoVAB PF13782.6 KOO34618.1 - 0.044 14.1 1.3 0.052 13.9 0.1 1.8 2 0 0 2 2 2 0 Stage V sporulation protein AB DUF5495 PF17599.2 KOO34618.1 - 0.14 12.4 0.2 9.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5495) ATP-synt_I PF03899.15 KOO34618.1 - 2 8.8 10.6 0.63 10.4 3.5 2.3 1 1 1 2 2 2 0 ATP synthase I chain TTc_toxin_rep PF18807.1 KOO34621.1 - 0.068 13.0 4.7 12 5.8 0.1 4.2 4 0 0 4 4 4 0 Tripartite Tc toxins repeat PKS_DE PF18369.1 KOO34621.1 - 0.29 11.7 16.9 8.2 7.1 0.7 4.6 4 0 0 4 4 4 0 Polyketide synthase dimerisation element domain Ank_2 PF12796.7 KOO34622.1 - 9.8e-87 285.7 32.3 3.4e-14 53.2 0.7 7.5 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34622.1 - 7.1e-62 205.0 17.4 8.9e-09 35.7 0.1 11.0 5 3 6 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO34622.1 - 9.6e-48 159.6 30.7 2.1e-08 34.2 0.6 12.3 1 1 13 14 14 14 14 Ankyrin repeats (many copies) Ank PF00023.30 KOO34622.1 - 2.7e-44 147.7 52.2 0.013 15.9 0.1 14.2 13 1 1 14 14 14 13 Ankyrin repeat Ank_3 PF13606.6 KOO34622.1 - 4.5e-36 118.8 19.2 0.021 15.3 0.0 14.1 14 0 0 14 14 14 11 Ankyrin repeat SR1P PF13790.6 KOO34622.1 - 5.1e-06 26.5 16.7 12 6.1 0.0 10.5 13 0 0 13 13 13 1 SR1 protein Robl_LC7 PF03259.17 KOO34622.1 - 0.0034 17.1 2.1 93 2.9 0.0 7.1 5 4 4 9 9 9 0 Roadblock/LC7 domain KdpD PF02702.17 KOO34622.1 - 0.059 12.8 0.0 16 4.9 0.0 4.3 6 0 0 6 6 6 0 Osmosensitive K+ channel His kinase sensor domain LIN37 PF15306.6 KOO34622.1 - 1.5 9.0 4.6 2.3e+02 1.9 0.0 4.8 6 0 0 6 6 6 0 LIN37 Phospholip_A2_2 PF05826.12 KOO34622.1 - 2.2 8.5 12.9 2.3 8.5 0.1 4.6 2 2 2 5 5 5 0 Phospholipase A2 DUF3613 PF12266.8 KOO34623.1 - 0.024 14.4 0.3 0.071 12.9 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3613) DUF4880 PF16220.5 KOO34623.1 - 2 8.4 7.1 0.19 11.6 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4880) MFS_1 PF07690.16 KOO34624.1 - 1.7e-26 93.0 42.1 2.1e-26 92.7 42.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOO34624.1 - 1.8e-24 86.4 18.9 2.6e-24 85.9 18.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter LRR_6 PF13516.6 KOO34627.1 - 1.9e-06 27.5 16.7 0.3 11.2 0.0 6.5 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 KOO34627.1 - 3.1e-05 24.2 5.1 0.13 12.7 0.1 3.8 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) Skp1 PF01466.19 KOO34627.1 - 0.00019 21.4 0.0 0.0053 16.8 0.0 3.0 3 0 0 3 3 3 1 Skp1 family, dimerisation domain LRR_1 PF00560.33 KOO34627.1 - 0.00053 20.2 0.1 6.7 7.7 0.1 4.8 5 0 0 5 5 5 1 Leucine Rich Repeat DUF2202 PF09968.9 KOO34627.1 - 0.17 11.7 0.1 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein domain (DUF2202) LRR_8 PF13855.6 KOO34627.1 - 2.3 8.1 8.4 20 5.0 0.1 4.3 3 2 0 3 3 3 0 Leucine rich repeat Glyco_transf_15 PF01793.16 KOO34628.1 - 6.6e-29 101.2 0.0 7.8e-29 101.0 0.0 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PHD PF00628.29 KOO34629.1 - 1.6e-29 101.5 53.6 2.7e-11 43.2 5.8 4.9 3 1 1 4 4 4 4 PHD-finger Bromodomain PF00439.25 KOO34629.1 - 8.9e-12 44.9 0.0 1.5e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Bromodomain MBD PF01429.19 KOO34629.1 - 0.00088 18.9 0.0 0.0023 17.6 0.0 1.7 1 0 0 1 1 1 1 Methyl-CpG binding domain PHD_2 PF13831.6 KOO34629.1 - 0.0019 17.7 8.1 0.0063 16.0 1.7 5.2 5 1 0 5 5 5 2 PHD-finger LBR_tudor PF09465.10 KOO34629.1 - 0.0027 17.4 0.0 0.011 15.6 0.1 1.9 2 0 0 2 2 2 1 Lamin-B receptor of TUDOR domain PQQ PF01011.21 KOO34629.1 - 0.084 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 PQQ enzyme repeat PQQ_2 PF13360.6 KOO34629.1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 PQQ-like domain C1_1 PF00130.22 KOO34629.1 - 1.5 8.7 49.5 5.1 7.1 0.6 6.6 5 1 0 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PAN_4 PF14295.6 KOO34631.1 - 0.0016 18.3 1.5 0.0048 16.8 1.5 1.8 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 KOO34631.1 - 0.02 14.8 0.5 0.055 13.4 0.5 1.7 1 0 0 1 1 1 0 PAN domain RdgC PF04381.12 KOO34631.1 - 0.26 10.5 0.0 0.41 9.9 0.0 1.2 1 0 0 1 1 1 0 Putative exonuclease, RdgC RVT_1 PF00078.27 KOO34633.1 - 1.3e-09 37.9 0.0 1.5e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAS PF00989.25 KOO34634.1 - 0.05 13.6 0.0 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 PAS fold Kelch_1 PF01344.25 KOO34636.1 - 0.041 13.5 0.1 0.082 12.5 0.1 1.5 1 0 0 1 1 1 0 Kelch motif Hydrolase_4 PF12146.8 KOO34637.1 - 0.085 12.1 1.7 8.6 5.5 1.1 2.2 1 1 0 2 2 2 0 Serine aminopeptidase, S33 zf-TRAF PF02176.18 KOO34638.1 - 3.6e-13 50.0 16.3 6.1e-12 46.0 9.4 3.3 3 0 0 3 3 3 2 TRAF-type zinc finger Sina PF03145.16 KOO34638.1 - 0.00032 20.7 12.6 0.014 15.4 5.1 3.0 1 1 2 3 3 3 2 Seven in absentia protein family zf-TRAF_2 PF15965.5 KOO34638.1 - 0.0014 19.1 6.0 0.0014 19.1 6.0 3.0 1 1 2 3 3 3 2 TRAF-like zinc-finger FAM184 PF15665.5 KOO34638.1 - 0.046 13.5 2.7 0.083 12.7 1.1 2.1 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B DUF790 PF05626.11 KOO34638.1 - 0.059 12.1 0.2 0.1 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF790) DUF4407 PF14362.6 KOO34638.1 - 0.19 11.0 7.6 0.027 13.8 1.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Apolipoprotein PF01442.18 KOO34638.1 - 2.2 8.1 10.2 0.18 11.6 4.0 2.2 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain HSCB_C PF07743.13 KOO34638.1 - 5.7 7.5 11.2 2.4 8.7 0.9 4.0 2 2 0 2 2 2 0 HSCB C-terminal oligomerisation domain EF-hand_6 PF13405.6 KOO34639.1 - 3.9e-10 38.8 1.1 0.00013 21.6 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO34639.1 - 9.5e-10 37.3 0.4 4e-05 22.9 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO34639.1 - 1.1e-07 31.0 2.2 0.0011 18.4 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34639.1 - 3.5e-07 30.6 4.3 2.1e-06 28.1 0.8 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO34639.1 - 0.0029 17.4 1.0 0.38 10.6 0.1 2.5 1 1 1 2 2 2 1 EF-hand domain pair KELK PF15796.5 KOO34639.1 - 0.012 16.0 3.5 0.012 16.0 3.5 4.9 6 1 0 6 6 5 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase FAM76 PF16046.5 KOO34639.1 - 0.037 13.4 3.7 0.28 10.5 0.2 2.5 2 0 0 2 2 2 0 FAM76 protein EF-hand_11 PF08976.11 KOO34639.1 - 0.066 14.1 0.0 0.2 12.6 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain HSBP1 PF06825.12 KOO34639.1 - 0.082 12.8 1.5 52 3.8 0.0 3.6 3 0 0 3 3 3 0 Heat shock factor binding protein 1 COG5 PF10392.9 KOO34639.1 - 0.4 10.9 7.3 8.3 6.6 2.7 3.8 3 0 0 3 3 3 0 Golgi transport complex subunit 5 MRF_C1 PF13887.6 KOO34639.1 - 3.1 7.0 5.2 13 5.0 0.1 3.4 4 0 0 4 4 4 0 Myelin gene regulatory factor -C-terminal domain 1 WD40 PF00400.32 KOO34641.1 - 6.4e-31 105.9 5.8 2.2e-06 28.3 0.0 5.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO34641.1 - 9.6e-06 25.8 0.5 0.1 12.9 0.2 3.8 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOO34641.1 - 0.013 14.8 0.0 0.063 12.6 0.0 1.9 2 0 0 2 2 2 0 WD40-like domain PQQ_3 PF13570.6 KOO34641.1 - 0.037 14.5 1.9 4.1 8.0 0.0 4.0 3 1 2 5 5 5 0 PQQ-like domain Hira PF07569.11 KOO34641.1 - 0.077 12.7 0.3 4.4 7.0 0.1 2.4 2 0 0 2 2 2 0 TUP1-like enhancer of split Nup160 PF11715.8 KOO34641.1 - 0.1 11.2 0.4 4.3 5.9 0.0 2.8 1 1 1 3 3 3 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 KOO34641.1 - 0.11 10.9 0.0 2.5 6.5 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain MOSC PF03473.17 KOO34641.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 MOSC domain Nucleoporin_N PF08801.11 KOO34641.1 - 0.16 10.7 0.0 23 3.6 0.0 3.1 1 1 3 4 4 4 0 Nup133 N terminal like VPDSG-CTERM PF18205.1 KOO34641.1 - 0.26 11.1 0.5 0.62 9.9 0.5 1.6 1 0 0 1 1 1 0 VPDSG-CTERM motif SAPS PF04499.15 KOO34642.1 - 0.00035 19.5 0.0 0.0011 17.8 0.0 1.8 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein NOA36 PF06524.12 KOO34642.1 - 3.3 7.0 6.5 6.4 6.0 6.5 1.4 1 0 0 1 1 1 0 NOA36 protein Dynamin_M PF01031.20 KOO34643.1 - 2.9e-41 141.6 0.0 1e-40 139.8 0.0 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 KOO34643.1 - 1.5e-39 135.7 0.0 2.3e-39 135.1 0.0 1.3 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 KOO34643.1 - 8e-12 45.2 0.1 1.1e-10 41.6 0.0 2.6 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KOO34643.1 - 7.2e-07 29.3 0.0 0.033 14.3 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase AIG1 PF04548.16 KOO34643.1 - 0.022 14.1 0.0 1.2 8.5 0.0 2.3 2 0 0 2 2 2 0 AIG1 family IIGP PF05049.13 KOO34643.1 - 0.042 12.9 0.1 0.67 9.0 0.0 2.5 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) FtsK_SpoIIIE PF01580.18 KOO34643.1 - 0.14 11.5 0.0 0.51 9.6 0.0 1.9 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.6 KOO34643.1 - 0.18 12.2 2.4 0.78 10.1 0.2 2.9 2 2 0 2 2 2 0 AAA ATPase domain IZUMO PF15005.6 KOO34643.1 - 0.37 11.3 1.5 0.7 10.4 0.3 2.0 2 1 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated ALF PF03752.13 KOO34644.1 - 0.048 13.6 0.9 0.12 12.3 0.3 2.0 2 0 0 2 2 2 0 Short repeats of unknown function DUF1664 PF07889.12 KOO34645.1 - 0.00065 19.7 0.2 0.00086 19.3 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Laminin_II PF06009.12 KOO34645.1 - 0.0026 17.8 0.1 0.0035 17.4 0.1 1.2 1 0 0 1 1 1 1 Laminin Domain II TRPM_tetra PF16519.5 KOO34645.1 - 0.0031 17.6 0.1 0.0077 16.3 0.0 1.7 2 0 0 2 2 2 1 Tetramerisation domain of TRPM BORCS7 PF16088.5 KOO34645.1 - 0.011 16.0 0.3 0.019 15.2 0.3 1.4 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 7 Dynamitin PF04912.14 KOO34645.1 - 0.015 14.7 0.1 0.02 14.2 0.1 1.3 1 0 0 1 1 1 0 Dynamitin Baculo_PEP_C PF04513.12 KOO34645.1 - 0.015 15.3 0.4 0.019 15.0 0.4 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PspA_IM30 PF04012.12 KOO34645.1 - 0.016 14.8 0.8 0.02 14.5 0.8 1.1 1 0 0 1 1 1 0 PspA/IM30 family DUF4164 PF13747.6 KOO34645.1 - 0.023 15.0 0.2 0.04 14.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) COG2 PF06148.11 KOO34645.1 - 0.044 13.9 0.2 0.059 13.5 0.2 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 ADIP PF11559.8 KOO34645.1 - 0.057 13.5 0.0 0.077 13.1 0.0 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 KOO34645.1 - 0.06 14.0 0.3 0.12 13.0 0.2 1.5 1 1 0 1 1 1 0 SlyX Sugarporin_N PF11471.8 KOO34645.1 - 0.086 12.8 5.4 1.5 8.9 2.9 2.5 1 1 1 2 2 2 0 Maltoporin periplasmic N-terminal extension YabA PF06156.13 KOO34645.1 - 0.1 13.3 0.1 0.15 12.7 0.1 1.2 1 0 0 1 1 1 0 Initiation control protein YabA Mating_N PF12731.7 KOO34645.1 - 0.14 12.2 1.0 0.33 11.1 1.0 1.6 1 1 0 1 1 1 0 Mating-type protein beta 1 CLZ PF16526.5 KOO34645.1 - 0.19 12.1 0.4 0.63 10.4 0.4 1.8 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SSrecog PF03531.14 KOO34646.1 - 1.3e-21 76.3 0.1 3.8e-21 74.8 0.1 1.9 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 KOO34646.1 - 2.1e-20 72.9 1.3 3.1e-20 72.4 0.6 1.6 2 0 0 2 2 2 1 Histone chaperone Rttp106-like HMG_box PF00505.19 KOO34646.1 - 3.5e-15 56.2 0.4 3.5e-15 56.2 0.4 2.2 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO34646.1 - 1.6e-10 41.4 2.5 4.8e-10 39.9 2.5 1.9 1 0 0 1 1 1 1 HMG-box domain POB3_N PF17292.2 KOO34646.1 - 8.7e-07 29.3 2.2 9.8e-06 25.9 0.1 2.9 2 1 1 3 3 3 1 POB3-like N-terminal PH domain HMG_box_5 PF14887.6 KOO34646.1 - 0.00059 19.8 2.4 0.00059 19.8 2.4 2.8 3 0 0 3 3 3 1 HMG (high mobility group) box 5 TFIIF_alpha PF05793.12 KOO34646.1 - 2.8 6.4 53.1 0.031 12.9 42.3 2.4 3 0 0 3 3 3 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Trypsin_2 PF13365.6 KOO34647.1 - 3.6e-32 112.4 3.6 4.3e-32 112.1 1.7 2.0 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.26 KOO34647.1 - 1.9e-15 57.3 0.0 2.8e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 KOO34647.1 - 2.9e-11 43.5 0.0 6.3e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO34647.1 - 3.4e-06 26.8 4.5 0.06 13.2 0.2 3.7 4 0 0 4 4 4 2 PDZ domain GRASP55_65 PF04495.14 KOO34647.1 - 0.024 14.9 0.0 0.056 13.8 0.0 1.7 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain Peptidase_S46 PF10459.9 KOO34647.1 - 0.028 13.1 0.2 0.049 12.3 0.2 1.3 1 0 0 1 1 1 0 Peptidase S46 PDZ PF00595.24 KOO34647.1 - 0.11 12.9 0.1 2.6 8.5 0.1 2.9 1 1 0 1 1 1 0 PDZ domain Peptidase_S29 PF02907.15 KOO34647.1 - 0.26 11.0 1.2 0.4 10.4 0.2 1.9 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease p450 PF00067.22 KOO34648.1 - 1.4e-13 50.5 0.0 2.5e-13 49.6 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 HrpJ PF07201.11 KOO34648.1 - 0.1 12.9 2.7 0.14 12.5 2.3 1.2 1 1 0 1 1 1 0 HrpJ-like domain DUF3494 PF11999.8 KOO34649.1 - 0.028 14.0 3.2 0.033 13.8 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3494) RVT_2 PF07727.14 KOO34651.1 - 7e-16 58.6 0.0 1e-15 58.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KOO34651.1 - 3e-11 43.5 0.0 6.1e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain ketoacyl-synt PF00109.26 KOO34653.1 - 6.2e-52 176.7 1.7 7.3e-52 176.5 1.0 1.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOO34653.1 - 2.9e-35 120.8 1.1 2.9e-35 120.8 1.1 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 KOO34653.1 - 0.0048 16.3 0.7 0.013 14.9 0.3 1.9 2 1 0 2 2 2 1 Thiolase, N-terminal domain Ketoacyl-synt_2 PF13723.6 KOO34653.1 - 0.12 12.0 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain GST_C_3 PF14497.6 KOO34654.1 - 1.4e-06 28.4 0.0 2.4e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOO34654.1 - 0.00013 21.9 0.0 0.00045 20.2 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOO34654.1 - 0.079 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain cNMP_binding PF00027.29 KOO34655.1 - 2.4e-07 30.7 0.0 8.7e-05 22.5 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DUF4333 PF14230.6 KOO34656.1 - 0.14 12.4 0.0 0.17 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4333) MAGE PF01454.19 KOO34657.1 - 0.089 12.5 8.9 0.81 9.4 2.7 2.3 2 0 0 2 2 2 0 MAGE family DUF2570 PF10828.8 KOO34657.1 - 0.14 12.0 4.3 0.44 10.4 4.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) pP_pnuc_2 PF18166.1 KOO34657.1 - 4 7.5 7.4 24 5.0 0.3 3.1 2 1 0 3 3 3 0 Predicted pPIWI-associating nuclease Hist_deacetyl PF00850.19 KOO34658.1 - 1.3e-49 169.4 0.0 2.7e-49 168.3 0.0 1.4 1 1 0 1 1 1 1 Histone deacetylase domain EF-hand_6 PF13405.6 KOO34659.1 - 1.3e-06 27.8 0.2 0.071 13.1 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain Ank_4 PF13637.6 KOO34659.1 - 5.5e-06 26.8 0.4 0.005 17.4 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_7 PF13499.6 KOO34659.1 - 1.9e-05 25.0 0.9 0.0055 17.1 0.4 3.0 2 0 0 2 2 2 1 EF-hand domain pair Ank_2 PF12796.7 KOO34659.1 - 4.8e-05 23.9 0.1 0.00011 22.7 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) EF-hand_1 PF00036.32 KOO34659.1 - 0.0014 18.0 0.0 0.21 11.2 0.0 2.6 2 0 0 2 2 2 1 EF hand Ank PF00023.30 KOO34659.1 - 0.0047 17.3 0.1 0.015 15.8 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.6 KOO34659.1 - 0.02 15.2 0.0 0.059 13.7 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34659.1 - 0.24 12.1 0.4 0.87 10.4 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeat DRY_EERY PF09750.9 KOO34659.1 - 3.6 7.9 7.6 0.32 11.3 2.2 2.0 2 0 0 2 2 2 0 Alternative splicing regulator Fringe PF02434.16 KOO34660.1 - 3.6e-06 26.6 0.0 4.9e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 KOO34660.1 - 1.6e-05 24.8 0.0 2.5e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase DUF16 PF01519.16 KOO34661.1 - 0.039 14.4 8.5 0.27 11.7 8.5 2.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 SSP160 PF06933.11 KOO34661.1 - 0.23 9.7 9.7 0.36 9.0 9.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF536 PF04394.14 KOO34661.1 - 6.2 6.8 16.2 6.2 6.8 1.8 3.5 2 1 1 3 3 3 0 Protein of unknown function, DUF536 DUF5381 PF17353.2 KOO34663.1 - 8 6.2 6.6 6.5 6.5 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5381) Ntox21 PF15526.6 KOO34664.1 - 2.7e-05 24.4 0.1 4.4 7.7 0.0 4.6 4 0 0 4 4 4 1 Novel toxin 21 DUF3327 PF11806.8 KOO34664.1 - 2.7e-05 24.8 1.0 9.8 6.9 0.0 4.3 4 0 0 4 4 4 2 Domain of unknown function (DUF3327) Iron_traffic PF04362.14 KOO34664.1 - 0.19 11.4 5.1 6.5 6.5 0.1 3.0 3 0 0 3 3 3 0 Bacterial Fe(2+) trafficking PD40 PF07676.12 KOO34664.1 - 0.32 11.0 4.8 46 4.1 0.2 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Glyco_hydro_32N PF00251.20 KOO34664.1 - 4.4 6.8 12.5 1.1 8.8 0.2 3.4 4 0 0 4 4 4 0 Glycosyl hydrolases family 32 N-terminal domain Topo_Zn_Ribbon PF08272.11 KOO34664.1 - 6.9 6.4 14.5 14 5.4 0.7 3.5 3 0 0 3 3 3 0 Topoisomerase I zinc-ribbon-like Aconitase_2_N PF06434.13 KOO34665.1 - 2.4e-89 298.4 0.0 4.2e-89 297.6 0.0 1.4 1 0 0 1 1 1 1 Aconitate hydratase 2 N-terminus Aconitase_B_N PF11791.8 KOO34665.1 - 7.7e-64 214.4 0.2 1.9e-63 213.1 0.3 1.7 2 0 0 2 2 2 1 Aconitate B N-terminal domain Aconitase PF00330.20 KOO34665.1 - 7.5e-43 147.2 0.0 2e-41 142.5 0.0 2.4 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) HisKA_3 PF07730.13 KOO34666.1 - 0.03 14.9 4.8 0.03 14.9 4.8 3.3 1 1 0 2 2 2 0 Histidine kinase Sbi-IV PF11621.8 KOO34666.1 - 0.78 10.1 3.9 0.26 11.7 0.4 2.1 2 0 0 2 2 2 0 C3 binding domain 4 of IgG-bind protein SBI Herpes_heli_pri PF05774.11 KOO34669.1 - 0.037 14.2 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus helicase-primase complex component Herpes_UL36 PF03586.13 KOO34669.1 - 0.073 12.4 0.7 0.13 11.5 0.7 1.4 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein Glyco_hydro_42 PF02449.15 KOO34670.1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 Beta-galactosidase SURNod19 PF07712.12 KOO34671.1 - 4.7e-07 28.9 0.0 1.3e-05 24.2 0.0 2.6 2 1 0 2 2 2 1 Stress up-regulated Nod 19 AI-2E_transport PF01594.16 KOO34672.1 - 9e-25 87.5 30.7 7e-24 84.6 30.7 1.9 1 1 0 1 1 1 1 AI-2E family transporter CCB1 PF12046.8 KOO34672.1 - 2.3 7.5 11.4 4.1 6.7 2.0 3.0 3 0 0 3 3 3 0 Cofactor assembly of complex C subunit B Pcc1 PF09341.10 KOO34673.1 - 0.003 17.7 6.6 1.5 9.0 0.0 4.4 2 2 2 4 4 4 2 Transcription factor Pcc1 IFT46_B_C PF12317.8 KOO34673.1 - 0.0072 16.1 0.0 0.0092 15.7 0.0 1.3 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal Endonuc_Holl PF10107.9 KOO34673.1 - 0.67 9.8 4.8 11 5.8 0.9 2.4 1 1 1 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase EF-1_beta_acid PF10587.9 KOO34673.1 - 2.1 8.9 3.9 47 4.6 0.2 2.8 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region PDZ_6 PF17820.1 KOO34676.1 - 3.3e-06 26.8 0.1 6.6e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO34676.1 - 0.026 14.9 0.0 0.054 13.9 0.0 1.5 1 0 0 1 1 1 0 PDZ domain PHM7_cyt PF14703.6 KOO34676.1 - 0.082 13.1 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter PDZ_2 PF13180.6 KOO34676.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Anoctamin PF04547.12 KOO34676.1 - 0.24 10.2 6.5 0.033 13.0 1.6 1.9 2 1 0 2 2 2 0 Calcium-activated chloride channel Sel1 PF08238.12 KOO34677.1 - 4.6e-63 208.2 66.8 7.1e-09 36.1 0.6 10.2 11 0 0 11 11 11 9 Sel1 repeat TRL PF13146.6 KOO34677.1 - 1.5e-05 25.2 0.5 7.1 7.0 0.0 6.1 4 2 2 7 7 7 1 TRL-like protein family PPR_long PF17177.4 KOO34677.1 - 0.00014 21.3 5.4 5.8 6.2 0.0 5.8 1 1 5 6 6 6 2 Pentacotripeptide-repeat region of PRORP Inhibitor_I48 PF10467.9 KOO34677.1 - 0.00017 21.5 0.1 1.3e+02 2.5 0.0 6.1 3 2 4 7 7 7 0 Peptidase inhibitor clitocypin RIC1 PF07064.13 KOO34677.1 - 0.038 13.4 0.1 15 4.9 0.0 3.9 2 1 1 3 3 3 0 RIC1 Pilin_N PF07790.11 KOO34677.1 - 0.12 13.3 0.0 82 4.2 0.0 4.0 4 1 1 5 5 5 0 Archaeal Type IV pilin, N-terminal TPR_7 PF13176.6 KOO34677.1 - 0.84 9.8 16.9 23 5.3 0.3 6.6 6 1 1 7 7 7 0 Tetratricopeptide repeat TonB_N PF16031.5 KOO34678.1 - 0.0049 17.4 5.1 0.0072 16.8 5.1 1.4 1 0 0 1 1 1 1 TonB polyproline region RVT_2 PF07727.14 KOO34680.1 - 0.14 11.8 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_8 PF13855.6 KOO34682.1 - 4.1e-36 122.5 52.7 2e-09 37.1 4.9 9.5 5 2 5 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 KOO34682.1 - 4.2e-25 87.4 43.5 8.4e-05 22.9 1.0 11.1 10 1 1 11 11 11 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO34682.1 - 3.2e-09 36.1 35.7 1.7 9.5 0.3 14.4 16 0 0 16 16 16 4 Leucine Rich Repeat PSII_BNR PF14870.6 KOO34682.1 - 6e-05 22.4 0.2 0.00017 20.9 0.2 1.7 1 1 0 1 1 1 1 Photosynthesis system II assembly factor YCF48 Sortilin-Vps10 PF15902.5 KOO34682.1 - 0.085 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, LRR_9 PF14580.6 KOO34682.1 - 4.4 6.8 9.0 39 3.7 0.0 4.3 2 2 4 6 6 6 0 Leucine-rich repeat ATP-synt_ab PF00006.25 KOO34683.1 - 3.4e-14 53.0 0.0 8.8e-12 45.1 0.0 2.3 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 KOO34683.1 - 0.014 15.7 0.0 0.51 10.7 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta chain, C terminal domain EF-hand_7 PF13499.6 KOO34684.1 - 0.00015 22.1 0.1 0.00038 20.8 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO34684.1 - 0.00044 20.0 0.2 0.0011 18.7 0.2 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO34684.1 - 0.0029 17.0 0.0 0.0062 16.0 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO34684.1 - 0.003 17.0 0.0 0.0062 16.0 0.0 1.5 1 0 0 1 1 1 1 EF hand Dockerin_1 PF00404.18 KOO34684.1 - 0.0054 16.9 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Dockerin type I domain Peptidase_S26 PF10502.9 KOO34685.1 - 1.5e-07 31.3 0.0 2.9e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 KOO34685.1 - 2e-06 27.7 0.0 3.8e-06 26.7 0.0 1.5 1 1 0 1 1 1 1 Peptidase S24-like RST PF12174.8 KOO34685.1 - 0.16 11.9 0.0 3.4 7.7 0.1 2.4 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain DUF4815 PF16075.5 KOO34685.1 - 0.21 9.9 0.0 0.28 9.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4815) ABC2_membrane PF01061.24 KOO34686.1 - 2.3e-38 131.8 6.4 3.4e-38 131.2 6.4 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 KOO34686.1 - 3.3e-24 86.0 0.0 8e-24 84.7 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 KOO34686.1 - 4.9e-09 36.4 0.1 0.00037 20.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 KOO34686.1 - 9e-08 31.6 6.6 5.1e-07 29.1 6.6 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 KOO34686.1 - 5.5e-07 29.2 7.0 5.5e-07 29.2 7.0 1.5 2 0 0 2 2 2 1 ABC-2 family transporter protein SMC_N PF02463.19 KOO34686.1 - 5.4e-05 22.7 1.6 0.00065 19.2 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOO34686.1 - 0.00013 22.4 0.5 0.00013 22.4 0.5 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOO34686.1 - 0.0037 17.5 0.0 0.011 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KOO34686.1 - 0.015 15.2 0.7 0.029 14.3 0.7 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 KOO34686.1 - 0.028 14.1 0.9 0.073 12.8 0.9 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 KOO34686.1 - 0.045 14.0 0.4 0.11 12.8 0.4 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOO34686.1 - 0.087 12.4 0.6 0.21 11.1 0.6 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOO34686.1 - 0.19 12.2 0.0 0.4 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO34686.1 - 0.2 11.5 0.5 0.43 10.5 0.5 1.5 1 0 0 1 1 1 0 NACHT domain Zeta_toxin PF06414.12 KOO34686.1 - 0.22 10.8 0.1 0.4 9.9 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin SH3_19 PF18597.1 KOO34687.1 - 0.006 16.4 0.0 0.009 15.8 0.0 1.2 1 0 0 1 1 1 1 Myosin X N-terminal SH3 domain CortBP2 PF09727.9 KOO34688.1 - 0.039 13.9 107.9 0.16 11.9 10.6 8.4 2 2 8 10 10 10 0 Cortactin-binding protein-2 NUP50 PF08911.11 KOO34688.1 - 0.96 10.2 4.4 2 9.1 0.2 3.6 2 1 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) MCPVI PF02993.14 KOO34688.1 - 2.7 7.8 32.5 21 4.8 0.2 9.3 2 2 7 9 9 9 0 Minor capsid protein VI SLATT_1 PF18181.1 KOO34689.1 - 1.6e-12 47.4 1.5 1.9e-12 47.2 1.5 1.1 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain 1 GTP_EFTU PF00009.27 KOO34692.1 - 1.3e-21 77.1 0.0 2.7e-21 76.0 0.0 1.6 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KOO34692.1 - 5e-08 33.2 0.3 1.6e-07 31.6 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 KOO34692.1 - 0.0034 17.3 0.2 0.0088 15.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 KOO34692.1 - 0.0036 17.4 0.0 0.009 16.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KOO34692.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOO34692.1 - 0.18 11.1 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Pirin_C_2 PF17954.1 KOO34694.1 - 7.3 6.8 52.0 26 5.1 0.1 13.9 18 0 0 18 18 18 0 Quercetinase C-terminal cupin domain DAO PF01266.24 KOO34695.1 - 1.2e-29 104.0 5.1 2.7e-16 60.1 1.5 5.5 2 2 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOO34695.1 - 8.4e-06 25.9 0.1 3.4e-05 24.0 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOO34695.1 - 0.0059 15.9 0.0 0.017 14.3 0.0 1.7 1 0 0 1 1 1 1 Thi4 family MtrD PF04207.12 KOO34695.1 - 0.23 11.1 0.4 8.6 6.0 0.1 2.3 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit D TIR_2 PF13676.6 KOO34696.1 - 2.5e-07 31.3 0.0 7e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 TIR domain HC2 PF07382.11 KOO34696.1 - 6.2e-07 29.7 46.5 1.1e-06 28.8 46.5 1.3 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Cwf_Cwc_15 PF04889.12 KOO34696.1 - 0.58 9.8 17.3 0.9 9.2 17.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Ank_5 PF13857.6 KOO34698.1 - 2.4e-12 46.8 0.3 1.6e-10 41.0 0.2 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO34698.1 - 1.8e-09 37.6 0.6 3.6e-05 24.0 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 KOO34698.1 - 2.7e-09 37.5 0.0 5.6e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34698.1 - 8e-08 32.7 0.1 3.6e-06 27.4 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34698.1 - 5.7e-07 29.3 0.2 0.00086 19.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat UQ_con PF00179.26 KOO34699.1 - 1.4e-06 28.1 0.0 4.8e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Dscam_C PF12355.8 KOO34699.1 - 0.053 14.5 2.0 0.12 13.4 2.0 1.5 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal C2 PF00168.30 KOO34700.1 - 9e-10 38.8 0.0 1.8e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain PDZ_6 PF17820.1 KOO34700.1 - 0.00014 21.6 0.1 0.00032 20.5 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO34700.1 - 0.00028 21.2 0.1 0.00054 20.3 0.1 1.5 1 0 0 1 1 1 1 PDZ domain TPR_2 PF07719.17 KOO34701.1 - 5.1e-30 101.2 18.4 6.3e-05 22.8 0.0 9.9 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34701.1 - 1.1e-27 94.6 16.2 7.9e-07 28.6 0.0 9.5 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_12 PF13424.6 KOO34701.1 - 1.8e-21 76.2 19.5 3.4e-05 24.0 0.1 7.7 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOO34701.1 - 1.3e-19 69.2 18.7 0.00029 21.4 0.1 8.7 4 2 6 10 10 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOO34701.1 - 2e-19 68.1 4.3 0.029 14.6 0.0 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO34701.1 - 1.6e-18 67.0 13.2 2.7e-06 27.8 0.5 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO34701.1 - 1.8e-18 66.9 8.2 0.00019 22.0 0.0 7.4 5 2 2 7 7 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO34701.1 - 1.1e-11 44.8 18.2 0.011 16.0 0.5 5.6 3 1 3 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KOO34701.1 - 1.2e-11 44.1 14.8 0.022 15.1 0.0 9.6 9 1 0 9 9 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO34701.1 - 1.5e-09 37.2 11.6 0.025 14.6 0.2 7.2 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO34701.1 - 1.6e-07 31.3 10.1 0.0012 18.9 0.5 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOO34701.1 - 6.5e-07 29.6 12.3 0.11 13.2 0.1 7.7 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO34701.1 - 1.7e-05 24.2 5.8 0.042 13.1 2.2 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO34701.1 - 0.00039 20.2 15.0 0.64 10.0 0.1 6.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO34701.1 - 0.00088 18.9 8.0 4.5 7.0 0.0 6.1 5 2 2 7 7 7 2 TPR repeat PknG_TPR PF16918.5 KOO34701.1 - 0.0057 15.4 0.2 0.01 14.6 0.2 1.3 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat ChAPs PF09295.10 KOO34701.1 - 0.013 14.5 0.6 0.047 12.7 0.1 2.0 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) Coatomer_WDAD PF04053.14 KOO34701.1 - 0.026 13.6 0.2 0.1 11.6 0.0 2.0 2 1 1 3 3 3 0 Coatomer WD associated region TPR_MalT PF17874.1 KOO34701.1 - 0.05 13.0 4.3 6.7 6.0 0.1 3.9 3 2 1 4 4 4 0 MalT-like TPR region DUF5113 PF17140.4 KOO34701.1 - 0.058 13.2 3.8 5.7 6.7 0.0 3.8 3 2 0 3 3 3 0 Domain of unknown function (DUF5113) PPR PF01535.20 KOO34701.1 - 0.16 12.3 3.2 34 5.0 0.0 5.0 5 0 0 5 5 4 0 PPR repeat Coatomer_E PF04733.14 KOO34701.1 - 0.69 9.3 3.2 12 5.2 0.0 3.0 2 1 2 4 4 4 0 Coatomer epsilon subunit BTAD PF03704.17 KOO34701.1 - 1.7 9.1 7.2 25 5.3 1.6 4.0 3 1 0 4 4 4 0 Bacterial transcriptional activator domain Ank_2 PF12796.7 KOO34702.1 - 1.8e-55 185.5 19.3 6.4e-13 49.1 0.1 6.3 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34702.1 - 3.3e-44 148.7 13.9 1.7e-10 41.2 0.1 8.4 2 1 7 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 KOO34702.1 - 7.5e-42 140.0 28.9 0.00034 20.9 0.0 11.3 11 0 0 11 11 11 10 Ankyrin repeat Ank_3 PF13606.6 KOO34702.1 - 7.5e-35 115.0 16.3 0.017 15.6 0.0 11.6 11 0 0 11 11 11 9 Ankyrin repeat Ank_5 PF13857.6 KOO34702.1 - 2.3e-32 110.6 24.8 6e-08 32.8 0.2 9.6 3 2 6 10 10 10 9 Ankyrin repeats (many copies) NACHT PF05729.12 KOO34702.1 - 0.00035 20.5 0.0 0.0012 18.8 0.0 1.9 2 0 0 2 2 2 1 NACHT domain Mic1 PF07035.12 KOO34702.1 - 0.0013 18.4 0.2 13 5.5 0.0 3.5 3 0 0 3 3 3 2 Colon cancer-associated protein Mic1-like LuxT_C PF18285.1 KOO34702.1 - 0.085 13.4 0.1 2.2 8.9 0.0 2.5 2 0 0 2 2 2 0 Tetracycline repressor LuxT C-terminal domain LRR_6 PF13516.6 KOO34704.1 - 3.4e-19 67.2 7.8 0.0049 16.8 0.1 6.5 6 1 0 6 6 6 5 Leucine Rich repeat HOASN PF14515.6 KOO34704.1 - 0.00011 22.5 10.4 0.88 10.0 0.3 4.7 1 1 3 4 4 4 3 Haem-oxygenase-associated N-terminal helices SpoU_sub_bind PF08032.12 KOO34704.1 - 0.00022 21.4 1.9 0.48 10.7 0.1 4.2 3 1 1 4 4 4 2 RNA 2'-O ribose methyltransferase substrate binding LRR_4 PF12799.7 KOO34704.1 - 0.0004 20.7 1.1 13 6.3 0.0 4.4 3 2 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO34704.1 - 0.00043 20.0 0.6 20 5.0 0.0 4.8 3 3 0 3 3 3 0 Leucine rich repeat Put_DNA-bind_N PF06971.13 KOO34704.1 - 0.019 14.9 2.8 37 4.4 0.0 4.8 5 0 0 5 5 5 0 Putative DNA-binding protein N-terminus EIF_2_alpha PF07541.12 KOO34704.1 - 0.026 14.6 0.3 1.5 8.9 0.1 2.4 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit FAM25 PF15825.5 KOO34704.1 - 0.21 11.9 20.2 13 6.3 0.6 6.0 5 1 1 6 6 6 0 FAM25 family CbiG_N PF11760.8 KOO34704.1 - 0.37 10.8 16.7 10 6.2 0.2 5.2 4 1 1 5 5 5 0 Cobalamin synthesis G N-terminal CoatB PF10389.9 KOO34704.1 - 1.1 9.2 14.4 3.9 7.4 0.4 4.7 5 1 1 6 6 6 0 Bacteriophage coat protein B CAP_N PF01213.19 KOO34705.1 - 1.9 7.9 5.4 2 7.8 5.4 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 KOO34705.1 - 2.7 8.0 5.8 2.9 7.9 5.8 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF1039 PF06287.11 KOO34707.1 - 0.044 14.2 0.0 0.14 12.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1039) DUF2205 PF10224.9 KOO34707.1 - 0.08 12.9 6.9 0.1 12.6 0.7 3.0 1 1 1 2 2 2 0 Short coiled-coil protein PcfJ PF14284.6 KOO34707.1 - 0.21 11.5 8.3 0.98 9.3 4.2 2.5 2 1 0 2 2 2 0 PcfJ-like protein FlaC_arch PF05377.11 KOO34707.1 - 0.5 10.8 4.6 1.7 9.1 0.4 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.12 KOO34707.1 - 0.51 10.4 8.7 0.083 12.9 3.2 2.3 1 1 1 2 2 2 0 Laminin Domain II DUF5082 PF16888.5 KOO34707.1 - 2.3 8.5 12.7 0.42 10.9 0.8 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) ZapB PF06005.12 KOO34707.1 - 3.2 8.3 15.1 0.64 10.5 4.8 3.5 2 2 0 2 2 2 0 Cell division protein ZapB BLOC1S3 PF15753.5 KOO34708.1 - 0.0046 17.1 2.2 0.0046 17.1 2.2 2.5 3 0 0 3 3 3 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 DPM3 PF08285.11 KOO34708.1 - 0.094 12.9 0.6 0.18 12.0 0.6 1.5 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) RINT1_TIP1 PF04437.13 KOO34709.1 - 2.8e-13 49.6 0.0 5.6e-09 35.4 0.0 2.0 1 1 1 2 2 2 2 RINT-1 / TIP-1 family Unstab_antitox PF09720.10 KOO34709.1 - 0.011 15.8 0.2 0.025 14.6 0.2 1.6 1 0 0 1 1 1 0 Putative addiction module component N6_N4_Mtase PF01555.18 KOO34711.1 - 1.8e-33 116.2 0.0 2.3e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 DNA methylase Methyltransf_11 PF08241.12 KOO34711.1 - 0.0069 17.0 0.0 0.021 15.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO34711.1 - 0.079 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain UPF0020 PF01170.18 KOO34711.1 - 0.094 12.4 0.0 0.48 10.1 0.0 2.0 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 TruB_N PF01509.18 KOO34712.1 - 1.7e-46 158.3 0.0 8e-46 156.1 0.0 1.8 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 KOO34712.1 - 4.7e-07 29.8 0.1 1.1e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain MgpC PF05220.12 KOO34712.1 - 0.036 13.4 0.0 0.34 10.2 0.0 2.0 2 0 0 2 2 2 0 MgpC protein precursor Kinesin PF00225.23 KOO34713.1 - 6.5e-26 91.0 0.0 2.3e-19 69.5 0.0 3.0 2 1 1 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 KOO34713.1 - 3.6e-08 33.5 0.0 2.7e-07 30.6 0.0 2.4 2 1 0 2 2 2 1 Microtubule binding DUF4472 PF14739.6 KOO34713.1 - 7.4e-08 33.1 10.5 7.4e-08 33.1 10.5 6.7 3 2 3 7 7 7 1 Domain of unknown function (DUF4472) ORF6C PF10552.9 KOO34713.1 - 0.22 11.6 3.4 1.4 9.0 0.4 2.9 2 0 0 2 2 2 0 ORF6C domain CppA_N PF14506.6 KOO34713.1 - 0.36 10.9 2.1 8.4 6.5 0.3 2.5 2 0 0 2 2 2 0 CppA N-terminal TctC PF03401.14 KOO34713.1 - 1.1 8.2 8.4 0.068 12.2 1.8 2.1 3 0 0 3 3 3 0 Tripartite tricarboxylate transporter family receptor RecG_N PF17190.4 KOO34713.1 - 2.7 8.8 6.4 9.6 7.0 0.7 3.9 3 1 0 3 3 3 0 RecG N-terminal helical domain SNARE PF05739.19 KOO34713.1 - 4.5 7.3 5.5 13 5.9 0.2 3.2 3 0 0 3 3 3 0 SNARE domain W2 PF02020.18 KOO34714.1 - 1.5e-12 47.5 8.1 1.5e-12 47.5 8.1 2.1 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.23 KOO34714.1 - 7.1e-07 29.0 0.0 1.6e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 KOO34714.1 - 4.4e-05 23.9 3.5 5.5e-05 23.6 0.4 2.5 3 0 0 3 3 3 1 MobA-like NTP transferase domain Hexapep PF00132.24 KOO34714.1 - 0.0012 18.5 3.5 0.0012 18.5 3.5 2.7 1 1 2 3 3 3 1 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 KOO34714.1 - 0.055 11.6 1.3 0.1 10.7 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Fucokinase PF07959.12 KOO34714.1 - 0.11 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.6 KOO34714.1 - 0.99 9.2 13.0 0.11 12.3 4.6 2.8 1 1 2 3 3 3 0 Hexapeptide repeat of succinyl-transferase Carn_acyltransf PF00755.20 KOO34715.1 - 3.7e-159 531.1 0.0 4.2e-159 530.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Rer1 PF03248.13 KOO34716.1 - 5.6e-72 241.0 10.7 6.6e-72 240.8 10.7 1.0 1 0 0 1 1 1 1 Rer1 family DUF2208 PF09973.9 KOO34716.1 - 0.024 14.3 2.5 0.024 14.3 2.5 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) SecD_SecF PF02355.16 KOO34716.1 - 0.037 13.4 0.3 0.087 12.2 0.0 1.6 2 0 0 2 2 2 0 Protein export membrane protein Halogen_Hydrol PF10112.9 KOO34716.1 - 0.23 11.4 3.5 5.3 7.0 0.0 2.1 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein TctA PF01970.16 KOO34716.1 - 2.9 6.5 6.2 0.25 10.0 0.3 1.8 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctA family Ank_2 PF12796.7 KOO34717.1 - 9.1e-12 45.4 0.2 7.9e-05 23.2 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO34717.1 - 3.9e-09 36.6 4.6 0.0004 20.6 0.0 3.7 3 2 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34717.1 - 1.3e-07 31.3 3.0 0.13 12.9 0.1 5.4 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 KOO34717.1 - 3.4e-07 30.4 12.1 0.28 11.7 0.1 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 KOO34717.1 - 6.5e-07 29.8 5.1 0.00099 19.6 0.7 4.4 3 2 1 4 4 4 2 Ankyrin repeats (many copies) Cas_VVA1548 PF09652.10 KOO34717.1 - 0.22 11.8 0.3 1.6 9.0 0.0 2.5 2 2 0 2 2 2 0 Putative CRISPR-associated protein (Cas_VVA1548) Exostosin PF03016.15 KOO34718.1 - 1.2e-55 188.9 0.0 1.6e-55 188.4 0.0 1.2 1 0 0 1 1 1 1 Exostosin family EGF_2 PF07974.13 KOO34718.1 - 0.063 13.7 16.8 0.16 12.4 16.8 1.7 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 KOO34718.1 - 0.17 12.0 8.8 0.28 11.4 5.6 2.4 2 0 0 2 2 2 0 Laminin EGF domain I-EGF_1 PF18372.1 KOO34718.1 - 0.94 9.6 11.2 2.3 8.4 11.2 1.7 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EGF_Tenascin PF18720.1 KOO34718.1 - 0.96 9.6 11.4 2.6 8.2 11.4 1.8 1 0 0 1 1 1 0 Tenascin EGF domain DUF503 PF04456.12 KOO34720.1 - 0.0051 16.6 6.1 0.013 15.3 6.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF503) RRM_1 PF00076.22 KOO34722.1 - 0.00088 19.1 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sgf11 PF08209.11 KOO34723.1 - 0.026 14.1 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) Pyr_redox_2 PF07992.14 KOO34724.1 - 5.1e-27 94.9 2.0 1.2e-26 93.7 2.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TIR_2 PF13676.6 KOO34724.1 - 1.2e-19 71.1 0.0 1.2e-08 35.5 0.0 3.4 3 0 0 3 3 3 2 TIR domain Pyr_redox PF00070.27 KOO34724.1 - 4e-09 36.9 0.2 4.9e-06 27.0 0.0 2.9 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase TIR PF01582.20 KOO34724.1 - 2.4e-08 34.0 0.2 0.00018 21.4 0.1 2.3 2 0 0 2 2 2 2 TIR domain Pyr_redox_3 PF13738.6 KOO34724.1 - 4.4e-06 26.2 0.7 0.0011 18.2 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOO34724.1 - 0.0021 17.3 0.0 0.042 13.0 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 KOO34724.1 - 0.013 15.1 6.2 0.95 9.0 0.0 4.0 4 1 1 5 5 5 0 FAD dependent oxidoreductase LytR_C PF13399.6 KOO34724.1 - 0.021 15.8 0.0 0.33 12.0 0.0 3.1 3 0 0 3 3 3 0 LytR cell envelope-related transcriptional attenuator Lycopene_cycl PF05834.12 KOO34724.1 - 0.046 12.8 0.3 0.93 8.5 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Ank_2 PF12796.7 KOO34725.1 - 1.3e-180 586.4 62.5 4.7e-19 68.8 0.4 10.1 1 1 12 13 13 13 13 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34725.1 - 5.5e-102 332.9 39.8 6.4e-09 36.2 0.0 13.9 3 2 14 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.30 KOO34725.1 - 3.2e-91 296.1 22.9 0.0006 20.2 0.0 18.0 18 0 0 18 18 18 17 Ankyrin repeat Ank_3 PF13606.6 KOO34725.1 - 8e-82 259.3 7.8 0.0046 17.3 0.0 17.9 17 1 1 18 18 18 17 Ankyrin repeat Ank_5 PF13857.6 KOO34725.1 - 3.8e-69 227.8 32.8 9e-07 29.1 0.0 15.3 2 2 15 17 17 17 17 Ankyrin repeats (many copies) DUF5583 PF17821.1 KOO34725.1 - 5.3e-14 52.3 12.8 0.063 13.2 0.0 9.0 1 1 9 10 10 10 5 Family of unknown function (DUF5583) 3HCDH_RFF PF18321.1 KOO34725.1 - 4e-06 27.2 41.1 7.1 7.2 0.3 13.3 5 4 10 15 15 15 2 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain DUF2099 PF09872.9 KOO34725.1 - 1.3e-05 24.5 6.1 63 2.6 0.0 9.0 1 1 12 14 14 14 0 Uncharacterized protein conserved in archaea (DUF2099) PP_kinase_C_1 PF17941.1 KOO34725.1 - 0.00011 21.7 27.0 26 4.3 0.1 12.3 11 3 3 14 14 14 0 Polyphosphate kinase C-terminal domain 1 Rop-like PF05082.13 KOO34725.1 - 0.00025 20.8 5.2 15 5.5 0.0 6.4 5 2 2 7 7 7 0 Rop-like Tox-REase-5 PF15648.6 KOO34725.1 - 0.00026 21.4 0.1 1e+02 3.5 0.0 7.5 4 3 8 12 12 11 0 Restriction endonuclease fold toxin 5 TIR_2 PF13676.6 KOO34725.1 - 0.00059 20.4 0.5 1e+02 3.5 0.0 5.6 1 1 7 8 8 8 0 TIR domain DUF3618 PF12277.8 KOO34725.1 - 1.6 9.0 8.6 76 3.7 0.1 6.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3618) Remorin_N PF03766.13 KOO34725.1 - 2 8.5 10.0 3.5 7.7 0.0 5.8 6 0 0 6 6 6 0 Remorin, N-terminal region Glyco_hydro_36C PF16874.5 KOO34725.1 - 2.1 8.9 11.5 43 4.7 0.0 7.5 9 1 0 9 9 8 0 Glycosyl hydrolase family 36 C-terminal domain NAD_binding_8 PF13450.6 KOO34725.1 - 3.1 8.1 11.8 4.5e+02 1.2 0.0 8.4 13 0 0 13 13 13 0 NAD(P)-binding Rossmann-like domain Ser_hydrolase PF06821.13 KOO34725.1 - 8.7 6.2 30.4 30 4.4 0.7 8.3 2 2 6 9 9 9 0 Serine hydrolase Peptidase_C58 PF03543.14 KOO34726.1 - 0.024 14.4 4.2 66 3.1 0.1 6.8 4 3 1 5 5 5 0 Yersinia/Haemophilus virulence surface antigen Pribosyltran PF00156.27 KOO34727.1 - 3.4e-15 55.9 0.0 4.4e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KOO34727.1 - 0.02 14.3 0.0 0.029 13.8 0.0 1.1 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Clathrin PF00637.20 KOO34728.1 - 4.8e-18 65.4 0.8 8.6e-08 32.2 0.0 2.5 2 0 0 2 2 2 2 Region in Clathrin and VPS MerR PF00376.23 KOO34728.1 - 0.024 14.4 0.0 0.062 13.1 0.0 1.7 2 0 0 2 2 2 0 MerR family regulatory protein FATC PF02260.20 KOO34730.1 - 0.48 10.3 1.6 1.1 9.1 0.1 2.2 2 0 0 2 2 2 0 FATC domain Cor1 PF04803.12 KOO34731.1 - 0.0078 16.4 5.2 0.0078 16.4 5.2 1.9 2 0 0 2 2 2 1 Cor1/Xlr/Xmr conserved region Asp23 PF03780.13 KOO34731.1 - 0.048 14.1 0.7 0.1 13.0 0.7 1.5 1 0 0 1 1 1 0 Asp23 family, cell envelope-related function GLE1 PF07817.13 KOO34731.1 - 0.056 12.6 2.8 0.073 12.3 2.8 1.3 1 1 0 1 1 1 0 GLE1-like protein Tht1 PF04163.12 KOO34731.1 - 0.38 9.5 4.5 0.48 9.1 4.5 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein TPR_2 PF07719.17 KOO34732.1 - 5.3e-06 26.1 6.3 0.02 15.0 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34732.1 - 8.9e-06 25.3 1.2 0.1 12.4 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO34732.1 - 0.00056 19.5 0.8 0.5 10.1 0.1 3.6 2 1 1 3 3 3 2 TPR repeat TPR_16 PF13432.6 KOO34732.1 - 0.013 16.2 17.0 0.029 15.0 5.5 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO34732.1 - 0.39 11.0 8.0 7.2 7.0 0.2 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat 2OG-FeII_Oxy_3 PF13640.6 KOO34733.1 - 3.5e-16 59.9 0.0 5.6e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.6 KOO34733.1 - 0.17 12.0 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily HPIP PF15226.6 KOO34734.1 - 3.7 8.0 6.9 0.56 10.6 0.2 2.3 2 0 0 2 2 2 0 HCF-1 beta-propeller-interacting protein family CutC PF03932.14 KOO34735.1 - 5.7e-65 218.6 0.2 9e-65 217.9 0.2 1.3 1 0 0 1 1 1 1 CutC family Glucokinase PF02685.16 KOO34735.1 - 1.5e-57 195.0 0.0 2.3e-57 194.4 0.0 1.3 1 0 0 1 1 1 1 Glucokinase DAO PF01266.24 KOO34737.1 - 3.1e-63 214.5 1.6 4.4e-63 214.0 1.6 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T PF01571.21 KOO34737.1 - 2.3e-54 184.5 0.0 4.2e-54 183.6 0.0 1.4 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain FAO_M PF16350.5 KOO34737.1 - 6.6e-12 45.6 0.3 1.3e-11 44.6 0.3 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain SoxG PF04268.12 KOO34737.1 - 3.8e-10 40.1 0.0 1.3e-09 38.4 0.0 1.8 2 0 0 2 2 2 1 Sarcosine oxidase, gamma subunit family Pyr_redox_2 PF07992.14 KOO34737.1 - 8.8e-08 31.7 0.0 0.0056 15.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOO34737.1 - 2.1e-07 30.1 1.9 3e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase FAD_binding_2 PF00890.24 KOO34737.1 - 4e-05 22.9 1.1 0.0081 15.3 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 KOO34737.1 - 0.00019 21.9 0.8 0.032 14.8 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 KOO34737.1 - 0.00023 20.8 0.7 0.0016 18.1 0.1 2.2 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 KOO34737.1 - 0.00029 20.2 0.0 0.13 11.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOO34737.1 - 0.0011 18.2 1.3 0.34 10.1 0.3 2.2 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.6 KOO34737.1 - 0.003 17.8 0.3 0.011 16.0 0.3 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GMC_oxred_N PF00732.19 KOO34737.1 - 0.0038 16.7 0.9 2.1 7.7 0.2 2.2 2 0 0 2 2 2 2 GMC oxidoreductase FAD_binding_3 PF01494.19 KOO34737.1 - 0.0041 16.4 0.5 0.014 14.6 0.5 1.8 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 KOO34737.1 - 0.025 13.9 0.4 0.092 12.1 0.4 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 KOO34737.1 - 0.028 13.1 0.2 0.063 12.0 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein ThiF PF00899.21 KOO34737.1 - 0.055 12.8 0.0 0.61 9.4 0.0 2.1 2 0 0 2 2 2 0 ThiF family GIDA PF01134.22 KOO34737.1 - 0.069 12.2 1.0 6.2 5.8 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A TrkA_N PF02254.18 KOO34737.1 - 0.13 12.5 0.0 0.38 11.0 0.0 1.8 1 0 0 1 1 1 0 TrkA-N domain Pkinase PF00069.25 KOO34738.1 - 6.6e-33 114.2 0.0 1.9e-32 112.7 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34738.1 - 4.8e-19 68.7 0.0 6e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO34738.1 - 0.00016 21.1 0.1 0.00024 20.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO34738.1 - 0.029 14.3 0.2 0.054 13.4 0.2 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO34738.1 - 0.031 13.1 0.0 0.037 12.8 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 KOO34738.1 - 0.16 11.3 0.0 0.22 10.8 0.0 1.1 1 0 0 1 1 1 0 Kinase-like IQ PF00612.27 KOO34740.1 - 7.2e-05 22.2 3.7 0.0056 16.4 1.3 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif TolA PF06519.11 KOO34740.1 - 0.00069 19.8 5.2 3.5 7.9 0.4 3.5 1 1 2 3 3 3 3 TolA C-terminal RVT_2 PF07727.14 KOO34741.1 - 8.1e-30 104.2 0.0 1.3e-29 103.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3638 PF12340.8 KOO34742.1 - 1.3e-25 90.0 0.4 2.4e-25 89.2 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KOO34742.1 - 3e-14 52.1 0.2 3e-14 52.1 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) TPR_11 PF13414.6 KOO34742.1 - 0.0086 15.7 0.0 0.03 14.0 0.0 2.0 1 0 0 1 1 1 1 TPR repeat IQ PF00612.27 KOO34743.1 - 0.00033 20.2 0.2 0.0012 18.5 0.2 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif PCMT PF01135.19 KOO34744.1 - 9.4e-19 68.0 0.0 1.9e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOO34744.1 - 2e-10 40.7 0.0 4e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain ANAPC10 PF03256.16 KOO34744.1 - 3.5e-08 33.3 0.0 7.4e-06 25.7 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex, subunit 10 (APC10) Ubie_methyltran PF01209.18 KOO34744.1 - 6.9e-05 22.3 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 KOO34744.1 - 0.00063 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain F5_F8_type_C PF00754.25 KOO34744.1 - 0.015 15.4 2.2 0.045 13.9 0.3 2.6 3 0 0 3 3 3 0 F5/8 type C domain DOT1 PF08123.13 KOO34744.1 - 0.033 13.7 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 CMAS PF02353.20 KOO34744.1 - 0.055 12.7 0.0 0.093 12.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase RrnaAD PF00398.20 KOO34744.1 - 0.068 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_4 PF02390.17 KOO34744.1 - 0.085 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase GCD14 PF08704.10 KOO34744.1 - 0.18 11.4 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Glyco_hydro_7 PF00840.20 KOO34745.1 - 5.7e-138 460.3 4.2 5.7e-138 460.3 4.2 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 7 PH PF00169.29 KOO34746.1 - 3.9e-17 62.7 0.0 1e-06 29.2 0.0 3.3 3 0 0 3 3 3 2 PH domain PH_9 PF15410.6 KOO34746.1 - 1.2e-05 25.7 0.1 4.6 7.6 0.0 3.5 3 0 0 3 3 3 3 Pleckstrin homology domain PhrC_PhrF PF11131.8 KOO34746.1 - 0.17 11.5 2.3 20 4.9 0.2 3.2 2 0 0 2 2 2 0 Rap-phr extracellular signalling Nup54_C PF18437.1 KOO34746.1 - 0.81 9.6 5.5 55 3.8 0.0 4.3 4 0 0 4 4 4 0 Nup54 C-terminal interacting domain PmbA_TldD PF01523.16 KOO34746.1 - 2 8.2 6.5 3.8 7.3 6.5 1.4 1 0 0 1 1 1 0 Putative modulator of DNA gyrase TPR_12 PF13424.6 KOO34747.1 - 1.9e-147 479.8 47.7 1.8e-19 69.8 0.5 7.5 1 1 8 9 9 9 9 Tetratricopeptide repeat TPR_10 PF13374.6 KOO34747.1 - 2e-122 396.2 26.5 2.6e-14 52.5 0.1 10.1 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34747.1 - 4.2e-44 146.6 4.3 7e-05 22.5 0.1 10.1 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_2 PF07719.17 KOO34747.1 - 4.5e-42 138.8 8.8 0.0029 17.6 0.2 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO34747.1 - 9.5e-40 137.0 8.6 5.9e-13 48.9 0.4 4.4 1 1 3 4 4 4 4 MalT-like TPR region TPR_7 PF13176.6 KOO34747.1 - 5.4e-39 129.4 23.0 0.00064 19.6 0.1 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_8 PF13181.6 KOO34747.1 - 1.3e-37 124.9 5.1 0.035 14.3 0.0 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_16 PF13432.6 KOO34747.1 - 1.6e-32 111.9 27.4 1.8e-06 28.5 1.5 9.1 4 2 4 8 8 8 8 Tetratricopeptide repeat TPR_4 PF07721.14 KOO34747.1 - 2.1e-32 108.4 10.9 0.11 13.2 0.1 10.7 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_19 PF14559.6 KOO34747.1 - 1.8e-22 79.6 28.1 4.3e-05 23.9 0.2 6.4 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOO34747.1 - 4.1e-21 73.9 29.3 0.14 13.1 0.4 10.2 7 2 3 10 10 10 6 Tetratricopeptide repeat TPR_17 PF13431.6 KOO34747.1 - 4.4e-18 64.3 15.6 0.2 12.1 0.1 10.1 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOO34747.1 - 2.1e-12 46.5 4.8 0.11 12.2 0.0 9.0 10 0 0 10 10 10 3 TPR repeat Osmo_CC PF08946.10 KOO34747.1 - 6.2e-10 39.2 8.2 15 5.9 0.0 9.5 9 0 0 9 9 9 0 Osmosensory transporter coiled coil RPN6_N PF18055.1 KOO34747.1 - 1.2e-09 38.5 3.8 1.3 9.4 0.0 6.5 3 2 4 7 7 7 2 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_5 PF12688.7 KOO34747.1 - 3.5e-09 36.9 22.8 0.014 15.6 0.7 5.4 1 1 5 6 6 6 4 Tetratrico peptide repeat TPR_6 PF13174.6 KOO34747.1 - 3.1e-07 30.6 13.1 26 5.7 0.0 9.8 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_3 PF07720.12 KOO34747.1 - 4.9e-07 29.6 0.0 3.4 7.7 0.0 7.7 9 0 0 9 9 9 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO34747.1 - 5.1e-07 29.8 0.0 5.6 7.3 0.0 6.1 2 2 3 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 HisKA_3 PF07730.13 KOO34747.1 - 7.5e-07 29.6 23.5 2.3 8.8 0.1 8.9 6 3 4 10 10 10 1 Histidine kinase Lectin_N PF03954.14 KOO34747.1 - 0.00032 20.4 1.4 2.8 7.7 0.0 4.2 2 1 2 5 5 5 1 Hepatic lectin, N-terminal domain RPN7 PF10602.9 KOO34747.1 - 0.00051 19.8 0.0 7.6 6.2 0.0 5.0 2 2 3 5 5 5 0 26S proteasome subunit RPN7 DUF4810 PF16068.5 KOO34747.1 - 0.0011 19.4 3.5 27 5.4 0.0 6.2 5 3 1 6 6 6 0 Domain of unknown function (DUF4810) PPR_1 PF12854.7 KOO34747.1 - 0.0014 18.3 8.6 20 5.0 0.0 8.0 9 0 0 9 9 9 0 PPR repeat YfdX PF10938.8 KOO34747.1 - 0.0041 17.1 14.6 11 5.9 0.2 7.8 6 2 0 7 7 7 0 YfdX protein V-SNARE_C PF12352.8 KOO34747.1 - 0.0049 17.1 2.0 27 5.2 0.0 6.2 7 1 1 8 8 8 0 Snare region anchored in the vesicle membrane C-terminus Sec16_C PF12931.7 KOO34747.1 - 0.027 14.1 2.0 20 4.7 0.0 4.8 2 2 2 5 5 5 0 Sec23-binding domain of Sec16 HEAT_PBS PF03130.16 KOO34747.1 - 0.24 12.2 30.1 43 5.2 0.2 9.3 10 0 0 10 10 9 0 PBS lyase HEAT-like repeat DUF3368 PF11848.8 KOO34747.1 - 0.42 10.4 10.1 12 5.7 0.2 7.0 9 0 0 9 9 9 0 Domain of unknown function (DUF3368) DED PF01335.21 KOO34747.1 - 0.46 10.8 14.8 43 4.5 0.3 6.2 3 2 5 8 8 8 0 Death effector domain CHASE3 PF05227.13 KOO34747.1 - 4.9 7.1 9.8 23 4.9 0.0 4.6 1 1 5 7 7 7 0 CHASE3 domain BT1 PF03092.16 KOO34748.1 - 1.2e-49 169.0 8.0 9.8e-30 103.3 0.7 2.3 2 0 0 2 2 2 2 BT1 family Ecm29 PF13001.7 KOO34749.1 - 6.1e-48 163.7 0.0 2.9e-29 102.1 0.0 3.5 2 1 2 4 4 4 2 Proteasome stabiliser HEAT PF02985.22 KOO34749.1 - 0.0001 22.2 25.1 4.7 7.8 0.0 10.8 11 0 0 11 11 11 3 HEAT repeat HEAT_2 PF13646.6 KOO34749.1 - 0.002 18.5 35.1 0.18 12.2 0.1 9.9 6 2 5 11 11 11 3 HEAT repeats CLASP_N PF12348.8 KOO34749.1 - 0.026 14.1 0.0 2.4 7.7 0.0 3.0 3 1 0 4 4 4 0 CLASP N terminal Tex_YqgF PF16921.5 KOO34750.1 - 0.026 15.0 0.0 0.11 12.9 0.0 2.1 1 0 0 1 1 1 0 Tex protein YqgF-like domain CheB_methylest PF01339.17 KOO34750.1 - 0.22 11.2 5.7 1.1 9.0 0.0 3.3 2 1 0 3 3 3 0 CheB methylesterase Ion_trans PF00520.31 KOO34751.1 - 1.7e-22 79.9 6.6 2.3e-22 79.4 6.6 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO34751.1 - 1.7e-06 27.9 4.9 1.7e-06 27.9 4.9 3.3 3 1 1 4 4 4 1 Ion channel EF-hand_1 PF00036.32 KOO34752.1 - 2.2e-24 83.1 2.1 6e-06 25.4 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO34752.1 - 3.1e-23 79.7 0.7 1.8e-06 27.4 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO34752.1 - 3.2e-23 82.0 0.3 2.3e-12 47.2 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO34752.1 - 4.8e-16 57.5 11.4 0.00012 21.4 0.0 5.0 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO34752.1 - 1.1e-13 50.8 7.3 0.00011 21.9 0.5 4.5 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO34752.1 - 0.00065 20.0 0.1 0.011 16.0 0.0 2.7 2 1 1 3 3 3 1 EF-hand domain EF-hand_4 PF12763.7 KOO34752.1 - 0.0022 17.9 0.1 1.3 9.0 0.1 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Selenoprotein_S PF06936.11 KOO34752.1 - 0.0033 17.3 6.0 0.0071 16.2 6.0 1.5 1 0 0 1 1 1 1 Selenoprotein S (SelS) SPARC_Ca_bdg PF10591.9 KOO34752.1 - 0.0097 16.2 1.0 4.9 7.5 0.1 3.2 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Peptidase_S49_N PF08496.10 KOO34752.1 - 6.1 6.9 9.5 21 5.1 9.5 1.9 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EF-hand_7 PF13499.6 KOO34753.1 - 0.0022 18.4 0.0 0.0048 17.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO34753.1 - 0.0061 16.0 0.0 0.033 13.7 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO34753.1 - 0.051 13.1 0.0 0.15 11.6 0.0 1.9 1 0 0 1 1 1 0 EF hand PAZ_siRNAbind PF12212.8 KOO34753.1 - 0.067 13.0 0.2 0.23 11.3 0.0 1.8 2 0 0 2 2 2 0 PAZ domain EF-hand_8 PF13833.6 KOO34753.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_4 PF12763.7 KOO34753.1 - 0.17 11.9 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Ank_5 PF13857.6 KOO34756.1 - 3.2e-24 84.7 3.3 1.6e-09 37.9 0.1 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO34756.1 - 6.8e-21 74.7 1.3 3e-10 40.6 0.2 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34756.1 - 1.1e-19 70.6 0.3 2.6e-08 34.2 0.1 3.4 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO34756.1 - 5.3e-19 67.7 1.5 0.00031 21.1 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 KOO34756.1 - 2.6e-17 61.1 0.3 0.016 15.7 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat DUF1930 PF09122.10 KOO34756.1 - 0.049 13.6 0.0 0.2 11.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1930) DUF3223 PF11523.8 KOO34756.1 - 0.062 14.2 0.0 15 6.5 0.0 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF3223) Sial-lect-inser PF09264.10 KOO34756.1 - 0.12 12.2 0.1 0.79 9.5 0.0 2.1 1 1 0 2 2 2 0 Vibrio cholerae sialidase, lectin insertion Lipid_DES PF08557.10 KOO34756.1 - 0.17 11.4 0.1 2e+02 1.6 0.0 3.8 4 0 0 4 4 4 0 Sphingolipid Delta4-desaturase (DES) Arm PF00514.23 KOO34757.1 - 7.5e-73 238.6 58.3 1e-08 34.9 0.3 14.0 13 1 0 13 13 13 12 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO34757.1 - 1.7e-20 72.8 4.7 0.0046 16.9 0.6 8.5 2 1 7 9 9 9 7 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KOO34757.1 - 1.8e-18 66.9 6.1 0.00037 20.1 0.0 6.3 1 1 3 6 6 6 5 Armadillo-like U-box PF04564.15 KOO34757.1 - 6.9e-08 32.6 0.0 1.4e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KOO34757.1 - 0.00035 20.3 0.0 0.0007 19.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit CdiI_2 PF18593.1 KOO34757.1 - 0.027 15.1 0.0 2.3 8.9 0.0 2.8 3 0 0 3 3 3 0 CdiI immunity protein zf-NOSIP PF15906.5 KOO34757.1 - 0.033 14.3 0.0 0.083 13.0 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein V-ATPase_H_N PF03224.14 KOO34757.1 - 0.057 12.7 0.0 24 4.1 0.0 3.0 1 1 3 4 4 4 0 V-ATPase subunit H DUF1454 PF07305.12 KOO34757.1 - 0.099 12.1 0.3 5.1 6.5 0.1 3.3 3 2 2 5 5 5 0 Protein of unknown function (DUF1454) Rhodanese PF00581.20 KOO34758.1 - 7.9e-08 32.8 0.0 1.3e-07 32.1 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain EF-hand_1 PF00036.32 KOO34759.1 - 1.5e-19 68.0 15.7 1.9e-06 27.0 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO34759.1 - 2e-18 64.6 9.2 1.8e-05 24.3 0.4 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO34759.1 - 1.1e-17 64.2 22.2 6.7e-09 36.1 4.4 2.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO34759.1 - 3.6e-15 54.7 7.7 3.7e-07 29.3 0.7 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO34759.1 - 2e-12 46.7 15.2 3.6e-05 23.5 0.8 3.8 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO34759.1 - 0.028 14.7 11.2 0.24 11.8 4.4 2.3 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Elong-fact-P_C PF09285.11 KOO34761.1 - 3.9e-23 81.0 0.5 8.3e-23 79.9 0.5 1.6 1 0 0 1 1 1 1 Elongation factor P, C-terminal EFP_N PF08207.12 KOO34761.1 - 1.8e-22 79.1 0.0 3.5e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain EFP PF01132.20 KOO34761.1 - 3.1e-17 62.3 1.7 3.1e-17 62.3 1.7 1.5 2 0 0 2 2 2 1 Elongation factor P (EF-P) OB domain PAS_9 PF13426.7 KOO34762.1 - 1.6e-26 92.6 0.0 6.3e-14 52.1 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 KOO34762.1 - 8.7e-09 35.4 0.0 0.00012 22.1 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.12 KOO34762.1 - 8.5e-06 26.0 0.0 0.0025 18.1 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 KOO34762.1 - 1.4e-05 25.0 0.0 0.0044 17.0 0.0 2.8 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 KOO34762.1 - 0.028 14.7 5.0 0.057 13.7 0.1 3.1 4 0 0 4 4 4 0 PAS fold Rhomboid_SP PF12595.8 KOO34764.1 - 0.091 12.1 4.1 0.1 12.0 4.1 1.1 1 0 0 1 1 1 0 Rhomboid serine protease Pkinase PF00069.25 KOO34765.1 - 9.2e-52 176.0 0.0 1.1e-51 175.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34765.1 - 5.2e-21 75.1 0.0 6.7e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO34765.1 - 2.9e-07 30.1 0.0 0.00013 21.4 0.0 2.5 2 1 0 2 2 2 2 Kinase-like APH PF01636.23 KOO34765.1 - 2.2e-06 27.8 0.4 8.1e-06 25.9 0.2 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO34765.1 - 2.7e-05 23.2 0.0 4e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 KOO34765.1 - 0.00043 19.9 0.0 0.00068 19.2 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.14 KOO34765.1 - 0.0012 18.2 0.0 0.0019 17.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOO34765.1 - 0.0031 17.1 0.0 0.0047 16.5 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase FTA2 PF13095.6 KOO34765.1 - 0.0058 16.3 0.0 0.66 9.6 0.0 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pex19 PF04614.12 KOO34766.1 - 3.8e-36 125.1 0.1 7.2e-29 101.3 0.0 2.2 2 0 0 2 2 2 2 Pex19 protein family fn3 PF00041.21 KOO34768.1 - 4.5e-14 52.6 0.0 1.3e-09 38.2 0.0 2.3 1 1 1 2 2 2 2 Fibronectin type III domain SHIPPO-rpt PF07004.12 KOO34768.1 - 4.5e-07 30.5 3.2 0.053 14.4 2.0 3.8 3 0 0 3 3 3 2 Sperm-tail PG-rich repeat Pur_ac_phosph_N PF16656.5 KOO34768.1 - 0.00013 22.5 0.4 0.024 15.2 0.1 2.6 1 1 1 2 2 2 1 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 KOO34768.1 - 0.08 13.3 0.0 2.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) PhoD_N PF16655.5 KOO34768.1 - 0.15 12.6 0.0 2.2 8.9 0.0 2.3 1 1 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain UCH PF00443.29 KOO34769.1 - 3.7e-41 141.3 0.0 5.2e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO34769.1 - 2.2e-16 60.4 0.0 5.9e-16 59.0 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rad60-SLD_2 PF13881.6 KOO34769.1 - 8e-05 22.7 0.0 0.00016 21.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOO34769.1 - 0.0031 17.2 0.0 0.0059 16.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Neur_chan_memb PF02932.16 KOO34770.1 - 5e-07 30.0 0.2 7.9e-07 29.4 0.2 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region KASH PF10541.9 KOO34771.1 - 0.039 14.2 2.5 0.1 12.9 2.5 1.7 1 0 0 1 1 1 0 Nuclear envelope localisation domain PH PF00169.29 KOO34772.1 - 2.9e-18 66.3 0.0 1.4e-17 64.1 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KOO34772.1 - 1.7e-06 28.4 0.4 8.3e-06 26.2 0.1 2.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 KOO34772.1 - 0.0014 19.0 0.0 0.0057 17.0 0.0 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain APG6_N PF17675.1 KOO34772.1 - 0.019 15.5 12.2 0.019 15.5 12.2 2.7 2 1 0 2 2 1 0 Apg6 coiled-coil region ATG16 PF08614.11 KOO34772.1 - 0.62 10.3 27.3 0.38 10.9 11.5 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF4140 PF13600.6 KOO34772.1 - 0.87 10.1 18.5 0.062 13.7 6.2 2.9 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF4337 PF14235.6 KOO34772.1 - 1.9 8.6 14.4 0.038 14.1 5.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) DUF5446 PF17522.2 KOO34772.1 - 2.2 8.5 9.1 7.9 6.7 1.8 3.5 2 1 1 3 3 3 0 Family of unknown function (DUF5446) Nsp1_C PF05064.13 KOO34772.1 - 2.4 8.0 8.6 0.46 10.3 3.3 2.2 2 0 0 2 2 2 0 Nsp1-like C-terminal region AAA_23 PF13476.6 KOO34772.1 - 3.3 8.2 9.3 0.39 11.2 2.9 2.1 2 0 0 2 2 2 0 AAA domain ADIP PF11559.8 KOO34772.1 - 3.9 7.5 17.2 0.15 12.1 6.5 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 KOO34772.1 - 8.3 5.7 22.6 0.044 13.1 7.2 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) DUF3037 PF11236.8 KOO34772.1 - 8.9 6.8 7.5 1.7 9.1 2.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3037) HAD PF12710.7 KOO34773.1 - 8.6e-11 42.6 0.0 9e-10 39.3 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO34773.1 - 1.2e-07 32.3 0.3 0.0097 16.2 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOO34773.1 - 7.4e-06 26.2 0.0 0.0053 16.9 0.0 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO34773.1 - 0.015 15.4 0.2 0.19 11.8 0.2 2.4 1 1 0 1 1 1 0 HAD-hyrolase-like MoCF_biosynth PF00994.24 KOO34773.1 - 0.13 11.9 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 Probable molybdopterin binding domain DUF2828 PF11443.8 KOO34774.1 - 3.5e-75 253.4 0.0 8.3e-52 176.1 0.0 3.9 2 2 1 3 3 3 3 Domain of unknown function (DUF2828) VWA_CoxE PF05762.14 KOO34774.1 - 1.5e-07 31.0 0.0 3.2e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_2 PF13519.6 KOO34774.1 - 0.00074 20.1 0.0 0.0016 19.0 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain HEAT PF02985.22 KOO34775.1 - 4.9e-05 23.2 10.8 0.19 12.1 0.1 5.9 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.23 KOO34775.1 - 0.0002 21.3 8.3 0.033 14.3 0.0 5.4 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO34775.1 - 0.0006 20.1 8.6 0.049 14.0 0.1 3.4 3 1 0 3 3 3 2 HEAT repeats RICTOR_V PF14668.6 KOO34775.1 - 0.00097 19.3 0.0 0.66 10.3 0.0 3.3 2 1 2 4 4 4 2 Rapamycin-insensitive companion of mTOR, domain 5 RICTOR_N PF14664.6 KOO34775.1 - 0.017 14.1 0.6 0.17 10.9 0.0 2.4 2 1 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term IFRD PF05004.13 KOO34775.1 - 0.13 11.3 5.2 0.17 11.0 0.8 2.3 1 1 1 2 2 2 0 Interferon-related developmental regulator (IFRD) Ion_trans_2 PF07885.16 KOO34776.1 - 4.5e-19 68.2 18.6 5.7e-13 48.6 6.3 2.5 2 0 0 2 2 2 2 Ion channel EF-hand_1 PF00036.32 KOO34776.1 - 1.2e-10 40.1 0.2 0.00054 19.3 0.3 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO34776.1 - 1.5e-10 41.4 0.0 4e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO34776.1 - 2.9e-09 36.0 0.9 0.00046 19.6 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO34776.1 - 1.6e-08 33.8 0.1 0.00056 19.6 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO34776.1 - 3.8e-07 29.9 0.0 9.2e-07 28.6 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO34776.1 - 0.00027 21.2 0.0 0.00054 20.2 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain Ion_trans PF00520.31 KOO34776.1 - 0.27 10.4 15.2 0.16 11.2 4.0 2.3 2 0 0 2 2 2 0 Ion transport protein BfiI_DBD PF18243.1 KOO34777.1 - 0.041 13.5 0.3 39 3.8 0.0 3.3 3 0 0 3 3 3 0 Metal-independent restriction enzyme BfiI DNA binding domain Leukocidin PF07968.12 KOO34777.1 - 0.34 10.8 1.1 12 5.7 0.1 2.4 2 0 0 2 2 2 0 Leukocidin/Hemolysin toxin family DUF5436 PF17504.2 KOO34778.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5436) YL1 PF05764.13 KOO34778.1 - 1.9 8.5 8.4 2.9 7.9 8.4 1.2 1 0 0 1 1 1 0 YL1 nuclear protein UDPG_MGDP_dh_N PF03721.14 KOO34780.1 - 1.4e-26 93.3 0.0 1.9e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 KOO34780.1 - 3.4e-12 46.4 0.3 1.3e-05 25.3 0.1 2.5 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, central domain ApbA PF02558.16 KOO34780.1 - 0.00066 19.3 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 KOO34780.1 - 0.0013 18.6 0.0 0.0021 18.0 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF5402 PF17393.2 KOO34780.1 - 0.021 14.8 0.0 0.94 9.4 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5402) NAD_Gly3P_dh_N PF01210.23 KOO34780.1 - 0.08 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.21 KOO34780.1 - 0.13 11.6 0.6 0.29 10.4 0.4 1.7 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain SBBP PF06739.11 KOO34781.1 - 3e-10 39.9 63.0 0.00097 19.1 1.8 7.3 7 0 0 7 7 7 6 Beta-propeller repeat Keratin_2_head PF16208.5 KOO34781.1 - 8.5 6.5 70.2 11 6.2 12.3 5.0 1 1 4 5 5 5 0 Keratin type II head UPF0016 PF01169.19 KOO34782.1 - 7.9e-37 125.4 27.1 2.1e-19 69.6 6.6 3.0 3 0 0 3 3 3 2 Uncharacterized protein family UPF0016 Pantoate_transf PF02548.15 KOO34782.1 - 0.0027 17.1 0.1 0.0044 16.4 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase Filamin PF00630.19 KOO34783.1 - 3.5e-32 111.3 0.0 9.7e-07 29.6 0.0 7.6 5 2 1 6 6 6 6 Filamin/ABP280 repeat C2 PF00168.30 KOO34783.1 - 2.1e-14 53.7 0.0 5.3e-14 52.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain Invasin_D3 PF09134.10 KOO34783.1 - 3.8e-13 49.5 3.7 0.00061 20.1 0.0 5.7 6 0 0 6 6 6 3 Invasin, domain 3 Big_1 PF02369.16 KOO34783.1 - 2e-08 34.1 0.2 0.092 12.8 0.0 4.9 4 0 0 4 4 4 3 Bacterial Ig-like domain (group 1) MG2 PF01835.19 KOO34783.1 - 0.044 14.2 0.0 2.9 8.4 0.0 3.8 4 0 0 4 4 4 0 MG2 domain Pol_alpha_B_N PF08418.10 KOO34783.1 - 0.45 10.4 12.9 0.59 10.1 10.9 2.0 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal PWWP PF00855.17 KOO34784.1 - 3e-07 30.7 0.1 9.1e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 PWWP domain CW_binding_2 PF04122.12 KOO34785.1 - 0.14 12.8 2.5 13 6.5 0.2 2.4 1 1 1 2 2 2 0 Putative cell wall binding repeat 2 LRR_6 PF13516.6 KOO34787.1 - 1e-12 47.0 13.8 7.1e-06 25.7 0.1 5.5 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.7 KOO34787.1 - 0.014 15.8 0.2 3.9 8.0 0.0 3.2 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) WD40 PF00400.32 KOO34788.1 - 1.1e-66 219.1 26.4 1e-08 35.6 0.1 7.6 8 0 0 8 8 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO34788.1 - 3.3e-23 82.2 6.5 0.0099 14.9 0.0 7.0 2 2 5 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO34788.1 - 2.9e-17 62.1 5.5 0.71 9.9 0.0 7.4 7 0 0 7 7 7 7 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 KOO34788.1 - 2.9e-17 62.7 1.1 0.51 10.7 0.0 6.9 2 2 5 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KOO34788.1 - 8.5e-12 44.2 0.0 0.024 13.0 0.0 5.2 2 2 3 5 5 5 5 WD repeat-containing and planar cell polarity effector protein Fritz IKI3 PF04762.12 KOO34788.1 - 2.7e-08 32.3 0.1 0.015 13.3 0.0 4.1 2 1 3 5 5 5 3 IKI3 family Nbas_N PF15492.6 KOO34788.1 - 3.8e-08 33.0 8.5 1.3 8.3 0.0 5.6 1 1 5 6 6 6 4 Neuroblastoma-amplified sequence, N terminal DUF1513 PF07433.11 KOO34788.1 - 2e-06 27.1 0.9 0.52 9.3 0.0 4.9 1 1 3 5 5 5 2 Protein of unknown function (DUF1513) WD40_like PF17005.5 KOO34788.1 - 6.4e-05 22.4 0.3 2.7 7.2 0.0 4.0 4 1 0 4 4 4 1 WD40-like domain rOmpB PF12334.8 KOO34788.1 - 0.012 15.1 9.2 5.1 6.5 0.0 5.9 5 2 0 7 7 7 0 Rickettsia outer membrane protein B Daxx PF03344.15 KOO34788.1 - 0.018 15.1 0.0 1.7e+02 2.4 0.0 4.9 6 0 0 6 6 6 0 Daxx N-terminal Rassf1C-interacting domain Utp8 PF10395.9 KOO34788.1 - 0.054 12.0 0.0 1.7 7.1 0.0 2.4 2 1 1 3 3 3 0 Utp8 family Il2rg PF15874.5 KOO34788.1 - 0.21 11.9 0.1 44 4.4 0.0 3.0 3 0 0 3 3 3 0 Putative Interleukin 2 receptor, gamma chain Ank_2 PF12796.7 KOO34789.1 - 2.8e-10 40.6 0.1 1.3e-09 38.5 0.1 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO34789.1 - 6.7e-08 32.2 0.6 0.25 12.0 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat EF-hand_7 PF13499.6 KOO34789.1 - 2.9e-06 27.6 0.1 0.017 15.6 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO34789.1 - 3.9e-06 26.4 0.1 0.11 12.5 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain Ank_5 PF13857.6 KOO34789.1 - 1.3e-05 25.4 0.1 0.057 13.8 0.1 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO34789.1 - 1.7e-05 25.0 3.7 0.016 15.6 0.2 3.7 3 0 0 3 3 3 1 Ankyrin repeat EF-hand_1 PF00036.32 KOO34789.1 - 0.00065 19.1 0.0 1.8 8.3 0.0 3.6 4 0 0 4 4 4 2 EF hand Laminin_G_3 PF13385.6 KOO34789.1 - 0.00069 19.8 0.1 0.0012 19.0 0.1 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Ank_4 PF13637.6 KOO34789.1 - 0.00083 19.9 1.0 0.0094 16.5 0.1 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) EF-hand_5 PF13202.6 KOO34789.1 - 0.018 14.5 0.5 1.6 8.3 0.0 3.1 3 0 0 3 3 3 0 EF hand PaO PF08417.12 KOO34790.1 - 1.9e-19 69.5 0.2 4e-19 68.5 0.0 1.6 2 0 0 2 2 2 1 Pheophorbide a oxygenase TMF_TATA_bd PF12325.8 KOO34792.1 - 0.017 15.3 7.3 0.017 15.3 7.3 7.5 3 2 3 7 7 7 0 TATA element modulatory factor 1 TATA binding Pox_A_type_inc PF04508.12 KOO34792.1 - 0.72 9.8 5.9 0.51 10.3 0.2 3.9 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF3287 PF11690.8 KOO34792.1 - 5.4 6.7 12.1 7.2 6.3 1.7 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3287) Galactosyl_T PF01762.21 KOO34793.1 - 1e-06 28.7 0.0 3.2e-06 27.1 0.0 1.8 2 1 0 2 2 2 1 Galactosyltransferase EF-hand_6 PF13405.6 KOO34793.1 - 0.00065 19.4 0.3 0.059 13.3 0.2 3.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO34793.1 - 0.00066 19.1 0.3 0.058 13.0 0.3 3.2 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 KOO34793.1 - 0.014 15.8 0.2 0.71 10.4 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_8 PF13833.6 KOO34793.1 - 0.028 14.2 0.6 1.3 8.9 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain pair MMPL PF03176.15 KOO34793.1 - 0.27 10.1 1.6 0.43 9.5 1.6 1.2 1 0 0 1 1 1 0 MMPL family ANAPC5 PF12862.7 KOO34794.1 - 0.092 12.8 0.1 0.092 12.8 0.1 1.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 TssO PF17561.2 KOO34794.1 - 0.14 12.3 4.2 1.1 9.3 1.7 2.2 1 1 1 2 2 2 0 Type VI secretion system, TssO CHASE6_C PF17150.4 KOO34794.1 - 0.26 12.0 0.3 0.26 12.0 0.3 2.4 2 1 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain RhoGAP PF00620.27 KOO34794.1 - 0.28 11.0 3.8 0.33 10.8 0.1 2.4 1 1 0 2 2 2 0 RhoGAP domain Cellulose_synt PF03552.14 KOO34794.1 - 0.32 9.4 2.3 0.4 9.1 2.3 1.0 1 0 0 1 1 1 0 Cellulose synthase PIN_12 PF16289.5 KOO34794.1 - 1.8 9.0 11.0 0.3 11.6 5.4 2.0 2 0 0 2 2 2 0 PIN domain RIC3 PF15361.6 KOO34794.1 - 3.7 7.9 6.9 8.2 6.8 6.9 1.6 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Vps16_C PF04840.12 KOO34795.1 - 1.1e-23 83.8 0.0 1.7e-22 79.9 0.0 2.0 2 0 0 2 2 2 1 Vps16, C-terminal region Kelch_6 PF13964.6 KOO34795.1 - 7.2e-09 35.6 4.5 0.0018 18.5 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 KOO34795.1 - 1.2e-08 34.4 1.4 0.0015 18.1 0.4 4.1 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KOO34795.1 - 2e-08 33.9 2.0 0.12 12.4 0.1 4.8 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 KOO34795.1 - 1.2e-07 31.6 0.6 0.01 15.8 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 KOO34795.1 - 1.5e-06 28.3 6.2 0.54 10.6 0.0 5.6 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO34795.1 - 1.1e-05 25.4 9.5 0.65 10.0 0.1 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain SAP PF02037.27 KOO34796.1 - 4.9e-07 29.3 5.7 2.7e-05 23.8 0.1 2.3 2 0 0 2 2 2 2 SAP domain Peptidase_U40 PF10464.9 KOO34796.1 - 0.1 12.2 4.2 16 5.1 0.0 4.4 3 1 1 4 4 4 0 Peptidase U40 Staph_haemo PF05480.11 KOO34796.1 - 0.12 12.1 1.4 0.41 10.4 1.4 2.0 1 0 0 1 1 1 0 Staphylococcus haemolytic protein AP2 PF00847.20 KOO34796.1 - 0.2 11.9 6.6 3.5 7.9 0.3 4.7 4 0 0 4 4 4 0 AP2 domain YppG PF14179.6 KOO34797.1 - 0.022 15.5 1.1 0.037 14.7 1.1 1.4 1 0 0 1 1 1 0 YppG-like protein BAALC_N PF06989.12 KOO34799.1 - 0.086 13.2 0.0 0.25 11.7 0.0 1.8 1 0 0 1 1 1 0 BAALC N-terminus TMF_DNA_bd PF12329.8 KOO34800.1 - 0.0073 16.3 1.2 0.0073 16.3 1.2 3.8 2 2 3 5 5 5 1 TATA element modulatory factor 1 DNA binding Exostosin PF03016.15 KOO34801.1 - 2.3e-16 59.9 0.0 3.4e-15 56.1 0.0 2.1 1 1 0 1 1 1 1 Exostosin family Ion_trans PF00520.31 KOO34803.1 - 3.9e-121 402.9 37.7 6.4e-49 166.4 7.3 4.0 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO34803.1 - 2e-07 30.1 3.8 2e-07 30.1 3.8 6.0 6 1 1 7 7 7 4 Polycystin cation channel PAN_2 PF08276.11 KOO34804.1 - 4.9 7.3 7.5 5.5 7.2 1.7 2.4 2 0 0 2 2 2 0 PAN-like domain NAD_binding_10 PF13460.6 KOO34805.1 - 1.5e-10 41.3 0.0 2.3e-10 40.7 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOO34805.1 - 1.9e-08 34.1 0.0 6.9e-08 32.2 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 KOO34805.1 - 5.5e-08 32.7 0.0 8.3e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 KOO34805.1 - 0.0021 17.5 0.0 0.039 13.3 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase TPT PF03151.16 KOO34806.1 - 1.1e-15 57.8 13.2 1.3e-15 57.5 13.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO34806.1 - 0.0015 18.7 22.8 0.025 14.7 7.4 2.4 2 1 0 2 2 2 2 EamA-like transporter family DUF423 PF04241.15 KOO34806.1 - 7.9 6.8 8.3 0.68 10.2 0.8 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF423) WD40 PF00400.32 KOO34807.1 - 4.3e-34 116.0 3.8 2.8e-10 40.6 0.2 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO34807.1 - 6.2e-12 45.1 0.7 0.00078 18.5 0.0 3.0 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO34807.1 - 7.9e-10 38.9 0.1 0.028 14.7 0.0 3.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO34807.1 - 2.7e-09 36.7 0.0 0.09 12.7 0.0 3.5 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO34807.1 - 8.8e-06 24.3 0.0 0.0034 15.8 0.0 2.6 1 1 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KOO34807.1 - 1.5e-05 25.0 0.1 2.1e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KOO34807.1 - 0.00013 21.4 0.0 0.0003 20.2 0.0 1.6 1 1 0 1 1 1 1 WD40-like domain Nbas_N PF15492.6 KOO34807.1 - 0.00031 20.2 0.8 1.6 8.0 0.0 2.9 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal BBS2_Mid PF14783.6 KOO34807.1 - 0.0011 19.0 0.0 0.0072 16.4 0.0 2.2 1 1 1 2 2 2 1 Ciliary BBSome complex subunit 2, middle region Utp8 PF10395.9 KOO34807.1 - 0.0027 16.3 0.1 0.003 16.1 0.1 1.0 1 0 0 1 1 1 1 Utp8 family dsrm PF00035.26 KOO34807.1 - 0.0093 16.7 0.2 17 6.2 0.1 3.0 3 0 0 3 3 3 0 Double-stranded RNA binding motif Plk4_PB1 PF18190.1 KOO34807.1 - 0.052 13.7 0.0 7.4 6.8 0.0 2.8 1 1 2 3 3 3 0 Polo-like Kinase 4 Polo Box 1 CIDE-N PF02017.15 KOO34807.1 - 0.073 13.1 0.0 52 4.0 0.0 3.3 1 1 0 3 3 3 0 CIDE-N domain DUF727 PF05303.12 KOO34807.1 - 0.16 12.0 0.0 26 4.9 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF727) DUF3694 PF12473.8 KOO34807.1 - 0.23 12.1 1.2 0.83 10.3 0.2 2.1 1 1 1 2 2 2 0 Kinesin protein Proteasome_A_N PF10584.9 KOO34807.1 - 0.53 10.0 5.6 51 3.7 0.1 3.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature HIG_1_N PF04588.13 KOO34808.1 - 5.1 7.4 5.4 1.1 9.6 0.6 2.3 2 1 0 2 2 2 0 Hypoxia induced protein conserved region Pkinase PF00069.25 KOO34809.1 - 1.2e-12 47.8 0.0 1.5e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34809.1 - 0.027 13.8 0.0 0.047 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase PPR_2 PF13041.6 KOO34810.1 - 1.4e-24 86.0 0.0 5.9e-10 39.2 0.0 4.2 2 1 2 4 4 4 4 PPR repeat family PPR PF01535.20 KOO34810.1 - 2.6e-24 83.7 0.0 1.2e-05 25.2 0.0 4.4 4 0 0 4 4 4 4 PPR repeat PPR_1 PF12854.7 KOO34810.1 - 3.3e-15 55.5 0.0 4.1e-05 23.2 0.0 4.3 4 0 0 4 4 4 3 PPR repeat PPR_3 PF13812.6 KOO34810.1 - 2.5e-13 49.9 0.0 2e-09 37.4 0.0 3.2 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO34810.1 - 4.1e-10 39.4 0.5 5e-05 22.8 0.0 2.0 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 KOO34810.1 - 0.025 15.1 0.4 3.5 8.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO34810.1 - 0.042 14.1 2.8 5 7.5 0.6 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF3322 PF11795.8 KOO34810.1 - 0.89 9.5 4.1 9.1 6.2 0.1 3.0 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) TPR_16 PF13432.6 KOO34810.1 - 2.1 9.1 13.0 8.6 7.1 0.3 4.9 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO34810.1 - 3.3 8.8 20.1 4.5 8.3 0.1 5.3 5 2 2 7 7 7 0 Tetratricopeptide repeat adh_short PF00106.25 KOO34811.1 - 1.4e-23 83.3 0.0 1.7e-15 57.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO34811.1 - 1.8e-17 63.7 0.0 1.6e-08 34.4 0.0 2.3 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOO34811.1 - 6.9e-08 32.6 0.0 1.2e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 KOO34811.1 - 0.0028 16.9 0.0 0.004 16.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 KOO34811.1 - 0.013 15.4 0.2 0.034 14.1 0.2 1.6 1 0 0 1 1 1 0 NAD(P)H-binding DUF4817 PF16087.5 KOO34811.1 - 0.028 14.2 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) Epimerase PF01370.21 KOO34811.1 - 0.066 12.7 0.0 2.5 7.5 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Glyco_tranf_2_3 PF13641.6 KOO34811.1 - 0.11 12.4 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DUF778 PF05608.12 KOO34811.1 - 0.17 12.2 0.0 0.23 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) Fringe PF02434.16 KOO34812.1 - 8.1e-23 81.1 0.0 1.3e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Fringe-like DUF604 PF04646.12 KOO34812.1 - 2.8e-10 40.1 0.0 4.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Glyco_transf_34 PF05637.12 KOO34812.1 - 0.071 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family Galactosyl_T PF01762.21 KOO34812.1 - 0.16 11.7 0.0 2.2 8.1 0.0 2.2 1 1 0 1 1 1 0 Galactosyltransferase 2OG-FeII_Oxy_3 PF13640.6 KOO34813.1 - 2.1e-06 28.5 0.2 9e-06 26.5 0.2 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 KOO34813.1 - 0.01 15.0 0.0 0.013 14.6 0.0 1.1 1 0 0 1 1 1 1 Poxvirus C4/C10 protein MMS19_N PF14500.6 KOO34815.1 - 0.039 13.5 0.0 0.1 12.2 0.0 1.7 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Kringle PF00051.18 KOO34816.1 - 1.8e-39 133.9 14.9 1.9e-22 79.3 2.3 2.8 2 0 0 2 2 2 2 Kringle domain Notch PF00066.17 KOO34816.1 - 1.7e-22 79.6 91.7 1.7e-07 31.6 11.4 5.7 5 0 0 5 5 5 5 LNR domain SOG2 PF10428.9 KOO34817.1 - 0.23 10.6 2.4 0.26 10.4 2.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein CDPS PF16715.5 KOO34818.1 - 0.025 14.2 0.1 0.043 13.5 0.1 1.3 1 0 0 1 1 1 0 Cyclodipeptide synthase Alpha_kinase PF02816.18 KOO34819.1 - 6e-21 75.4 0.0 9.3e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family Rad51 PF08423.11 KOO34819.1 - 1.8e-05 24.1 0.0 3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_16 PF13191.6 KOO34819.1 - 0.026 14.9 1.3 0.18 12.2 1.3 2.3 1 1 0 1 1 1 0 AAA ATPase domain ICAT PF06384.11 KOO34820.1 - 2.6e-18 66.0 6.9 4.6e-18 65.2 0.1 2.2 2 0 0 2 2 2 1 Beta-catenin-interacting protein ICAT GvpG PF05120.12 KOO34820.1 - 0.0056 16.7 9.4 0.018 15.0 0.0 2.6 2 1 0 2 2 2 1 Gas vesicle protein G CAMP_factor PF07373.11 KOO34820.1 - 0.0099 15.5 0.4 0.015 15.0 0.4 1.2 1 0 0 1 1 1 1 CAMP factor (Cfa) T2SSF PF00482.23 KOO34820.1 - 0.024 14.6 6.1 0.22 11.5 0.5 3.2 2 1 0 3 3 3 0 Type II secretion system (T2SS), protein F MTS PF05175.14 KOO34820.1 - 0.052 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain FlxA PF14282.6 KOO34820.1 - 0.08 12.9 1.1 0.13 12.2 1.1 1.3 1 0 0 1 1 1 0 FlxA-like protein Methyltransf_25 PF13649.6 KOO34820.1 - 0.092 13.5 0.1 0.28 11.9 0.1 1.8 1 0 0 1 1 1 0 Methyltransferase domain IclR PF01614.18 KOO34820.1 - 0.27 11.1 2.0 0.36 10.7 0.6 1.8 2 0 0 2 2 2 0 Bacterial transcriptional regulator DUF883 PF05957.13 KOO34820.1 - 3.8 8.2 10.2 0.4 11.3 4.2 2.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Arm PF00514.23 KOO34821.1 - 1.1e-20 72.9 24.7 6.1e-05 22.9 0.0 9.5 10 1 1 11 11 11 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO34821.1 - 0.00013 22.3 19.1 0.027 14.8 0.3 5.3 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 KOO34821.1 - 0.014 15.6 10.4 0.59 10.5 0.0 5.4 5 0 0 5 5 5 0 HEAT repeat SRP68 PF16969.5 KOO34821.1 - 0.064 12.3 0.0 0.097 11.7 0.0 1.2 1 0 0 1 1 1 0 RNA-binding signal recognition particle 68 Methyltransf_11 PF08241.12 KOO34822.1 - 1.5e-07 32.0 0.0 2.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 KOO34822.1 - 1.5e-05 23.8 0.0 1.6e-05 23.6 0.0 1.0 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_23 PF13489.6 KOO34822.1 - 0.00013 21.8 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO34822.1 - 0.00021 21.1 0.0 0.00024 20.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO34822.1 - 0.00049 20.7 0.0 0.00077 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO34822.1 - 0.016 16.0 0.0 0.023 15.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 KOO34822.1 - 0.039 13.3 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Sulfotransfer_3 PF13469.6 KOO34823.1 - 0.049 14.0 0.9 0.13 12.7 0.9 1.8 1 1 0 1 1 1 0 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO34823.1 - 0.09 12.2 0.2 0.29 10.6 0.1 1.9 1 1 0 1 1 1 0 Sulfotransferase domain AIM5 PF17050.5 KOO34823.1 - 0.14 12.9 0.4 0.44 11.4 0.4 1.8 1 0 0 1 1 1 0 Altered inheritance of mitochondria 5 PRIMA1 PF16101.5 KOO34823.1 - 2.3 8.3 6.0 5.9 7.0 6.0 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 EF-hand_1 PF00036.32 KOO34824.1 - 1.8e-22 77.1 4.7 2.7e-07 29.6 0.2 6.6 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.6 KOO34824.1 - 5.6e-22 78.0 3.2 4.4e-08 33.4 0.3 4.5 3 1 2 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO34824.1 - 1.1e-18 65.5 3.8 7.1e-05 22.4 0.1 6.6 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 KOO34824.1 - 2.5e-16 59.3 2.0 1.5e-05 24.7 0.0 5.6 5 1 1 6 6 6 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO34824.1 - 1.4e-07 30.7 6.1 0.0057 16.1 0.1 5.1 5 0 0 5 5 5 2 EF hand EF-hand_9 PF14658.6 KOO34824.1 - 7.9e-06 26.1 0.0 0.013 15.9 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain TerB PF05099.13 KOO34824.1 - 0.0076 16.2 0.1 0.19 11.7 0.0 2.4 2 0 0 2 2 2 1 Tellurite resistance protein TerB EF-hand_4 PF12763.7 KOO34824.1 - 0.022 14.7 0.0 4.8 7.2 0.0 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Leukocidin PF07968.12 KOO34825.1 - 0.0017 18.3 1.4 2.3 8.1 0.1 3.0 3 0 0 3 3 3 2 Leukocidin/Hemolysin toxin family HS1_rep PF02218.15 KOO34825.1 - 8.1 6.9 0.0 8.1 6.9 0.0 3.8 4 0 0 4 4 4 0 Repeat in HS1/Cortactin cNMP_binding PF00027.29 KOO34827.1 - 6e-33 112.8 0.3 4.7e-17 61.8 0.0 2.9 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Arm PF00514.23 KOO34827.1 - 7.6e-14 51.2 19.2 0.0039 17.2 0.1 8.4 8 0 0 8 8 8 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO34827.1 - 0.0011 19.4 6.8 1.9 9.1 0.2 5.3 3 1 1 4 4 4 2 HEAT-like repeat Arm_2 PF04826.13 KOO34827.1 - 0.0051 16.3 0.0 6.2 6.2 0.0 3.1 2 1 1 3 3 3 2 Armadillo-like HEAT PF02985.22 KOO34827.1 - 0.28 11.6 6.0 1.1e+02 3.4 0.1 6.0 5 0 0 5 5 5 0 HEAT repeat IQ PF00612.27 KOO34827.1 - 0.86 9.6 3.9 12 6.0 0.7 3.3 2 0 0 2 2 2 0 IQ calmodulin-binding motif DEAD PF00270.29 KOO34828.1 - 1.7e-39 135.4 0.0 2.6e-39 134.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO34828.1 - 2.5e-18 66.4 0.0 2.3e-17 63.4 0.0 2.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO34828.1 - 0.0067 16.5 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KOO34828.1 - 0.02 15.2 0.3 0.13 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain SecA_DEAD PF07517.14 KOO34828.1 - 0.044 13.1 0.0 2.3 7.4 0.0 2.2 2 0 0 2 2 2 0 SecA DEAD-like domain CMS1 PF14617.6 KOO34828.1 - 0.07 12.4 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit ELFV_dehydrog PF00208.21 KOO34829.1 - 1.1e-27 97.3 0.0 1.8e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 KOO34829.1 - 5.3e-13 47.5 0.0 9.7e-09 33.4 0.0 3.6 4 0 0 4 4 4 3 Bacterial NAD-glutamate dehydrogenase FeS_assembly_P PF01883.19 KOO34830.1 - 6.7e-16 58.2 0.0 1.3e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein RNA_pol_Rpb2_6 PF00562.28 KOO34831.1 - 1.2e-123 413.0 0.0 1.5e-123 412.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_4 PF04566.13 KOO34831.1 - 2.3e-16 59.8 0.1 5.8e-16 58.5 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 KOO34831.1 - 2.7e-14 53.5 0.1 6.5e-14 52.2 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_7 PF04560.20 KOO34831.1 - 2.8e-14 53.3 0.2 5.9e-14 52.2 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 Myb_DNA-binding PF00249.31 KOO34832.1 - 8e-07 29.2 0.1 0.0043 17.2 0.0 2.7 1 1 2 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO34832.1 - 0.012 15.8 0.1 0.045 14.0 0.1 1.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain Pentapeptide_4 PF13599.6 KOO34833.1 - 7.3e-48 160.6 0.0 0.00075 19.6 0.0 13.0 4 4 8 14 14 14 12 Pentapeptide repeats (9 copies) XK-related PF09815.9 KOO34833.1 - 0.00021 20.5 7.2 0.00041 19.5 7.2 1.4 1 1 0 1 1 1 1 XK-related protein Ribosomal_L13e PF01294.18 KOO34833.1 - 0.0012 18.7 49.6 7.4 6.4 0.0 19.0 8 8 18 27 27 27 2 Ribosomal protein L13e DUF4110 PF13422.6 KOO34833.1 - 0.042 13.9 1.7 38 4.4 0.0 5.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4110) 2-ph_phosp PF04029.14 KOO34833.1 - 0.1 11.7 0.3 2 7.6 0.0 3.2 4 0 0 4 4 4 0 2-phosphosulpholactate phosphatase SinI PF08671.10 KOO34833.1 - 0.11 12.3 1.1 0.41 10.5 0.1 2.6 3 0 0 3 3 3 0 Anti-repressor SinI Peptidase_S74 PF13884.6 KOO34833.1 - 0.16 12.3 0.3 1.3e+02 3.0 0.0 5.2 5 0 0 5 5 5 0 Chaperone of endosialidase DUF3110 PF11360.8 KOO34834.1 - 8.2e-22 77.2 0.0 1.2e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3110) DUF1244 PF06844.11 KOO34835.1 - 1.5e-29 101.9 0.1 2.8e-29 101.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1244) MoCF_biosynth PF00994.24 KOO34835.1 - 2.2e-24 85.8 0.1 1.9e-22 79.5 0.0 2.6 2 1 0 2 2 2 1 Probable molybdopterin binding domain ASF1_hist_chap PF04729.13 KOO34836.1 - 2e-67 225.9 0.0 2.2e-67 225.8 0.0 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Ank_2 PF12796.7 KOO34837.1 - 2.8e-127 415.6 56.3 3.4e-15 56.4 0.0 11.3 3 2 11 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34837.1 - 3.1e-72 238.1 19.8 3e-06 27.6 0.0 16.0 8 4 7 16 16 16 15 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO34837.1 - 9e-67 220.3 43.3 1.8e-07 31.3 0.2 17.0 7 5 13 20 20 20 18 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34837.1 - 3e-65 208.4 25.2 0.00035 20.8 0.0 21.6 22 0 0 22 22 22 19 Ankyrin repeat Ank PF00023.30 KOO34837.1 - 1.4e-62 205.6 79.8 0.00047 20.5 0.0 22.0 22 0 0 22 22 22 20 Ankyrin repeat HEAT PF02985.22 KOO34838.1 - 1.6e-10 40.3 9.0 0.0018 18.3 0.0 5.0 5 0 0 5 5 5 3 HEAT repeat Cnd1 PF12717.7 KOO34838.1 - 1.8e-05 24.8 0.1 0.0096 16.0 0.0 2.9 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOO34838.1 - 2.2e-05 24.8 10.0 0.0016 18.8 1.7 3.5 3 1 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 KOO34838.1 - 0.001 19.5 12.7 0.89 10.1 0.0 4.6 5 0 0 5 5 5 3 HEAT-like repeat Adaptin_N PF01602.20 KOO34838.1 - 0.13 10.8 0.0 1.4 7.4 0.0 2.0 1 1 1 2 2 2 0 Adaptin N terminal region Cohesin_HEAT PF12765.7 KOO34838.1 - 0.17 12.2 10.5 8.6 6.8 0.2 4.4 4 1 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion RasGEF_N_2 PF14663.6 KOO34838.1 - 0.4 11.1 1.6 25 5.3 0.1 3.5 2 1 2 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain KH_1 PF00013.29 KOO34839.1 - 0.17 11.8 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 KH domain zf-C3HC4_2 PF13923.6 KOO34840.1 - 1e-07 31.7 3.4 2.8e-07 30.3 3.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CXXC PF02008.20 KOO34840.1 - 2.3e-06 27.5 2.4 2.3e-06 27.5 2.4 2.4 2 1 0 2 2 1 1 CXXC zinc finger domain zf-C3HC4 PF00097.25 KOO34840.1 - 3.7e-06 26.7 2.8 3.7e-06 26.7 2.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO34840.1 - 5.7e-06 26.6 4.6 5.7e-06 26.6 4.6 2.1 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 KOO34840.1 - 5.3e-05 23.4 1.3 0.00013 22.1 1.3 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 KOO34840.1 - 0.00018 21.3 5.1 0.00018 21.3 5.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO34840.1 - 0.0038 17.1 2.8 0.0089 15.9 2.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOO34840.1 - 0.0042 17.0 2.5 0.0042 17.0 2.5 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_5 PF17121.5 KOO34840.1 - 0.0064 16.4 2.2 0.023 14.5 2.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KOO34840.1 - 0.093 12.5 4.7 0.22 11.4 4.7 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 KOO34840.1 - 0.37 11.0 7.1 0.096 12.9 2.2 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KOO34840.1 - 2.3 8.3 10.0 0.036 14.1 2.5 1.8 2 0 0 2 2 2 0 RING-type zinc-finger EF-hand_7 PF13499.6 KOO34841.1 - 1.9e-10 41.0 0.1 4.9e-10 39.7 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO34841.1 - 1.7e-09 36.6 0.6 3.8e-05 22.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO34841.1 - 5.7e-09 35.1 0.9 9.4e-05 21.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO34841.1 - 1.1e-07 31.2 0.3 0.00016 21.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO34841.1 - 5.5e-05 22.9 0.3 0.00023 20.9 0.3 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO34841.1 - 0.00025 21.3 0.0 0.00069 19.9 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain DUF3810 PF12725.7 KOO34841.1 - 2.7 7.3 4.3 7.7 5.8 4.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) SDA1 PF05285.12 KOO34842.1 - 2 7.8 28.7 2.2 7.6 28.7 1.1 1 0 0 1 1 1 0 SDA1 AGTRAP PF06396.11 KOO34843.1 - 0.078 12.8 2.2 0.18 11.6 2.2 1.6 1 0 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) Dimer_Tnp_Tn5 PF02281.16 KOO34843.1 - 0.081 12.6 0.1 3.4 7.4 0.1 2.4 2 0 0 2 2 2 0 Transposase Tn5 dimerisation domain Kelch_5 PF13854.6 KOO34845.1 - 3.2e-26 90.8 6.4 2.7e-08 33.6 0.3 6.8 6 2 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KOO34845.1 - 8.1e-21 73.8 13.8 9.5e-07 28.7 0.3 7.1 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO34845.1 - 1.3e-15 57.0 5.0 0.0018 18.5 0.1 6.4 5 1 1 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KOO34845.1 - 1.8e-15 56.8 16.7 1.8e-06 28.1 0.1 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KOO34845.1 - 2e-08 33.6 10.9 0.0057 16.2 0.1 5.6 6 1 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KOO34845.1 - 2.4e-08 33.6 3.4 0.0023 17.9 0.1 5.4 5 0 0 5 5 5 2 Kelch motif Aminotran_1_2 PF00155.21 KOO34846.1 - 1.4e-44 152.7 0.0 1.7e-44 152.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Pkinase PF00069.25 KOO34847.1 - 7.5e-45 153.3 0.0 1.2e-44 152.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34847.1 - 3e-23 82.4 0.0 4.3e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO34847.1 - 0.00023 21.2 0.9 0.00039 20.4 0.1 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO34847.1 - 0.0046 16.3 0.0 0.007 15.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO34847.1 - 0.024 14.0 0.1 0.049 13.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO34847.1 - 0.068 11.9 0.0 0.37 9.5 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase DUF2258 PF10015.9 KOO34847.1 - 0.33 11.1 1.2 0.7 10.1 1.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) ANF_receptor PF01094.28 KOO34848.1 - 5.8e-14 52.0 0.0 3.2e-07 29.8 0.0 3.0 2 1 0 2 2 2 2 Receptor family ligand binding region MFS_1 PF07690.16 KOO34851.1 - 9e-14 51.2 39.9 7.6e-07 28.4 16.1 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOO34851.1 - 0.74 8.6 10.5 0.17 10.7 0.3 2.2 1 1 0 2 2 2 0 MFS_1 like family Bestrophin PF01062.21 KOO34852.1 - 2.9e-12 46.6 0.4 3.6e-12 46.3 0.4 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel YtpI PF14007.6 KOO34852.1 - 0.19 11.9 1.4 0.5 10.5 1.4 1.7 1 0 0 1 1 1 0 YtpI-like protein Cpn60_TCP1 PF00118.24 KOO34853.1 - 3.5e-155 517.4 13.4 3.9e-155 517.2 13.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cupin_4 PF08007.12 KOO34854.1 - 1.4e-07 31.3 0.0 0.00013 21.5 0.0 2.1 2 0 0 2 2 2 2 Cupin superfamily protein Cupin_8 PF13621.6 KOO34854.1 - 7e-05 22.7 0.0 8.7e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Arm PF00514.23 KOO34858.1 - 1.5e-58 193.2 35.5 1.6e-08 34.3 0.0 10.1 10 0 0 10 10 10 10 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 KOO34858.1 - 1.7e-06 27.7 0.5 0.39 10.1 0.0 4.8 2 1 1 4 4 4 2 Armadillo-like HEAT_EZ PF13513.6 KOO34858.1 - 3.4e-06 27.4 37.9 0.0027 18.2 0.6 6.3 5 2 2 7 7 7 3 HEAT-like repeat Atx10homo_assoc PF09759.9 KOO34858.1 - 0.0018 18.3 0.3 8.2 6.5 0.0 4.4 3 2 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain SBP_bac_8 PF13416.6 KOO34858.1 - 0.0021 17.9 10.3 1.5 8.5 0.1 4.7 2 2 2 4 4 4 3 Bacterial extracellular solute-binding protein RPAP1_C PF08620.10 KOO34858.1 - 0.0022 18.1 0.6 30 4.8 0.0 5.8 6 0 0 6 6 6 0 RPAP1-like, C-terminal RICTOR_N PF14664.6 KOO34858.1 - 0.0024 16.9 0.0 0.67 8.9 0.0 2.8 1 1 2 3 3 3 2 Rapamycin-insensitive companion of mTOR, N-term HEAT PF02985.22 KOO34858.1 - 0.044 14.0 14.4 12 6.4 0.0 7.3 8 0 0 8 8 8 0 HEAT repeat Fungal_TACC PF12709.7 KOO34859.1 - 0.12 12.8 1.6 1.7 9.2 0.0 3.2 3 0 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Prefoldin_2 PF01920.20 KOO34859.1 - 0.16 12.0 5.2 3.1 7.8 0.2 3.3 2 0 0 2 2 2 0 Prefoldin subunit DUF4094 PF13334.6 KOO34859.1 - 1.2 9.6 4.9 0.63 10.5 1.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) SAP PF02037.27 KOO34860.1 - 0.026 14.3 0.8 0.036 13.8 0.1 1.6 2 0 0 2 2 2 0 SAP domain CSD PF00313.22 KOO34861.1 - 1.2e-26 92.3 0.3 1.4e-26 92.1 0.3 1.1 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KOO34861.1 - 2.9e-05 23.7 0.1 4.6e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 Ribonuclease B OB domain DUF3572 PF12096.8 KOO34861.1 - 0.18 12.1 0.0 0.23 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3572) DIM1 PF02966.16 KOO34862.1 - 6.6e-20 71.2 0.0 9.1e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredox_DsbH PF03190.15 KOO34862.1 - 0.007 16.3 0.0 0.018 15.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF255 Glyco_hydro_76 PF03663.14 KOO34863.1 - 2.2e-47 162.3 17.3 2.7e-47 162.1 17.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_127 PF07944.12 KOO34863.1 - 0.0032 16.1 0.0 0.013 14.0 0.0 1.8 2 0 0 2 2 2 1 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_88 PF07470.13 KOO34863.1 - 0.075 12.1 7.6 0.23 10.5 0.1 2.1 1 1 1 2 2 2 0 Glycosyl Hydrolase Family 88 Acetyltransf_16 PF05301.11 KOO34865.1 - 2e-45 154.7 0.0 2.5e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.7 KOO34865.1 - 0.11 13.0 0.0 0.26 11.8 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO34865.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Aa_trans PF01490.18 KOO34866.1 - 2.1e-31 109.1 11.6 1.7e-20 73.2 4.6 2.0 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein F-box-like PF12937.7 KOO34869.1 - 1.5e-06 28.0 1.8 1.5e-06 28.0 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KOO34869.1 - 0.00093 19.0 0.9 0.002 17.9 0.0 2.0 2 0 0 2 2 2 1 F-box domain EF-hand_8 PF13833.6 KOO34870.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair p450 PF00067.22 KOO34871.1 - 3.4e-43 148.1 0.0 4.4e-43 147.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lactamase_B PF00753.27 KOO34872.1 - 1.1e-08 35.3 3.2 7.9e-08 32.5 3.2 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOO34872.1 - 0.0007 19.2 0.2 0.0017 17.9 0.2 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KOO34872.1 - 0.029 14.3 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 Beta-lactamase superfamily domain FAD_binding_3 PF01494.19 KOO34873.1 - 5.8e-25 88.3 4.2 3.6e-24 85.7 4.2 2.1 1 1 0 1 1 1 1 FAD binding domain Radical_SAM PF04055.21 KOO34873.1 - 1.4e-06 28.8 0.0 3.2e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily NAD_binding_8 PF13450.6 KOO34873.1 - 7.9e-05 22.8 0.6 0.0003 20.9 0.6 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO34873.1 - 0.00023 20.9 4.8 0.00024 20.8 2.3 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOO34873.1 - 0.0025 17.1 1.5 0.0038 16.5 0.5 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase M20_dimer PF07687.14 KOO34873.1 - 0.026 14.4 0.0 0.059 13.3 0.0 1.6 1 0 0 1 1 1 0 Peptidase dimerisation domain Pyr_redox PF00070.27 KOO34873.1 - 0.058 14.0 0.9 0.18 12.4 0.9 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KOO34873.1 - 0.068 12.2 0.8 4.7 6.2 0.2 3.0 3 0 0 3 3 3 0 Lycopene cyclase protein Imm1 PF14430.6 KOO34873.1 - 0.081 13.6 0.3 0.33 11.6 0.0 2.2 2 0 0 2 2 2 0 Immunity protein Imm1 AAA_5 PF07728.14 KOO34874.1 - 1.1e-19 70.8 0.0 1.2e-18 67.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) VWA_2 PF13519.6 KOO34874.1 - 8.5e-10 39.2 0.0 2.7e-09 37.6 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 KOO34874.1 - 3.9e-08 33.7 0.0 7.2e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA_3 PF07726.11 KOO34874.1 - 2.5e-06 27.4 0.0 5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) VWA_3 PF13768.6 KOO34874.1 - 3.2e-05 23.9 0.0 0.00052 20.0 0.0 2.7 3 1 0 3 3 3 1 von Willebrand factor type A domain AAA_16 PF13191.6 KOO34874.1 - 9.2e-05 22.9 0.1 9.2e-05 22.9 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 KOO34874.1 - 0.00014 21.7 0.0 0.00026 20.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA PF00004.29 KOO34874.1 - 0.00028 21.3 0.0 0.00077 19.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KOO34874.1 - 0.0021 17.5 0.0 0.0066 15.9 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI VWA_CoxE PF05762.14 KOO34874.1 - 0.0027 17.1 0.0 0.022 14.2 0.0 2.2 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein AAA_22 PF13401.6 KOO34874.1 - 0.0067 16.7 0.1 0.049 13.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_lid_8 PF17868.1 KOO34874.1 - 0.044 13.7 0.1 0.13 12.2 0.1 1.8 1 0 0 1 1 1 0 AAA lid domain AAA_33 PF13671.6 KOO34874.1 - 0.056 13.6 0.0 0.35 11.0 0.0 2.4 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 KOO34874.1 - 0.12 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain SET PF00856.28 KOO34875.1 - 2.7e-12 47.4 0.0 4.5e-11 43.4 0.0 2.2 1 1 0 1 1 1 1 SET domain Ank_2 PF12796.7 KOO34876.1 - 1.3e-60 201.9 13.2 3.1e-13 50.1 0.0 7.6 4 2 2 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34876.1 - 2.1e-43 146.1 11.3 2.4e-09 37.5 0.0 9.7 6 4 5 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO34876.1 - 1.8e-37 126.9 14.8 1.4e-06 28.5 0.0 10.9 5 3 6 11 11 11 9 Ankyrin repeats (many copies) Ank PF00023.30 KOO34876.1 - 4.2e-35 118.7 14.6 0.0073 16.7 0.0 12.1 11 0 0 11 11 11 8 Ankyrin repeat Ank_3 PF13606.6 KOO34876.1 - 8.5e-34 111.8 14.7 0.17 12.5 0.0 12.4 12 0 0 12 12 11 9 Ankyrin repeat ART PF01129.18 KOO34876.1 - 2.3e-07 30.4 0.0 6.6e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase EF-hand_5 PF13202.6 KOO34876.1 - 6.7e-05 22.2 2.2 0.0077 15.7 0.0 3.7 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 KOO34876.1 - 0.00079 19.2 0.3 0.064 13.2 0.0 3.8 3 0 0 3 3 3 1 EF-hand domain ADPrib_exo_Tox PF03496.14 KOO34876.1 - 0.00099 18.5 0.0 0.0035 16.7 0.0 1.9 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme EF-hand_1 PF00036.32 KOO34876.1 - 0.0021 17.5 1.2 0.099 12.2 0.0 3.8 4 0 0 4 4 4 1 EF hand EF-hand_7 PF13499.6 KOO34876.1 - 0.0034 17.8 0.4 0.1 13.1 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain pair YabA PF06156.13 KOO34876.1 - 0.67 10.6 6.3 0.78 10.4 1.4 3.2 2 0 0 2 2 2 0 Initiation control protein YabA Pro_CA PF00484.19 KOO34876.1 - 0.99 9.7 3.3 22 5.3 1.9 3.3 2 0 0 2 2 2 0 Carbonic anhydrase COG2 PF06148.11 KOO34876.1 - 5 7.2 8.0 4.3 7.4 1.8 2.8 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FOXP-CC PF16159.5 KOO34876.1 - 8.1 7.2 7.3 0.73 10.5 0.7 2.8 2 0 0 2 2 1 0 FOXP coiled-coil domain TPD52 PF04201.15 KOO34876.1 - 8.3 6.0 8.4 0.37 10.4 1.3 2.4 2 0 0 2 2 2 0 Tumour protein D52 family Y_phosphatase2 PF03162.13 KOO34877.1 - 1e-56 191.0 0.0 1.2e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 KOO34877.1 - 2.6e-09 37.4 0.0 2e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KOO34877.1 - 0.00073 19.2 0.0 0.00089 18.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KOO34877.1 - 0.0012 18.7 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Zip PF02535.22 KOO34878.1 - 1.8e-12 47.1 5.4 3.5e-12 46.2 5.4 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter UCH PF00443.29 KOO34879.1 - 1.9e-26 93.1 0.2 4.8e-15 55.7 0.0 3.1 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO34879.1 - 2e-11 44.0 0.0 0.00024 20.8 0.0 2.7 1 1 2 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 KOO34879.1 - 9.8e-07 28.4 0.0 0.0011 18.7 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family C_LFY_FLO PF17538.2 KOO34880.1 - 0.094 12.2 0.0 14 5.1 0.0 2.5 2 0 0 2 2 2 0 DNA Binding Domain (C-terminal) Leafy/Floricaula Phage-MuB_C PF09077.11 KOO34880.1 - 0.14 12.1 3.2 21 5.1 0.0 3.9 4 0 0 4 4 4 0 Mu B transposition protein, C terminal Bestrophin PF01062.21 KOO34881.1 - 2e-25 89.8 1.8 2.7e-25 89.4 1.8 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel TIP49 PF06068.13 KOO34882.1 - 5.2e-160 532.4 2.4 5.2e-160 532.4 2.4 1.5 2 0 0 2 2 2 1 TIP49 P-loop domain TIP49_C PF17856.1 KOO34882.1 - 2.3e-26 91.7 0.7 5.5e-26 90.5 0.7 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 KOO34882.1 - 2e-08 34.7 2.7 1.9e-05 25.1 0.2 3.3 2 2 1 3 3 3 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 KOO34882.1 - 1e-06 28.3 0.6 2e-06 27.3 0.6 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain RuvB_N PF05496.12 KOO34882.1 - 1.5e-06 28.0 0.9 0.0013 18.5 0.2 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOO34882.1 - 3.2e-06 27.6 0.5 3.3e-05 24.4 0.5 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KOO34882.1 - 1e-05 25.5 0.5 0.0035 17.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOO34882.1 - 1.4e-05 25.3 1.7 0.036 14.3 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KOO34882.1 - 0.00013 22.4 1.8 0.00073 19.9 1.8 2.2 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 KOO34882.1 - 0.00013 21.7 0.1 0.19 11.5 0.1 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 KOO34882.1 - 0.00026 20.6 0.1 0.00074 19.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KOO34882.1 - 0.0004 19.8 1.2 0.0092 15.4 0.4 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 KOO34882.1 - 0.00094 18.6 0.9 0.0017 17.7 0.9 1.4 1 0 0 1 1 1 1 KaiC Zeta_toxin PF06414.12 KOO34882.1 - 0.003 16.9 0.3 0.0074 15.6 0.3 1.6 1 0 0 1 1 1 1 Zeta toxin NACHT PF05729.12 KOO34882.1 - 0.01 15.7 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 KOO34882.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 KOO34882.1 - 0.027 14.0 0.1 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_17 PF13207.6 KOO34882.1 - 0.042 14.3 1.0 0.12 12.8 0.5 2.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOO34882.1 - 0.044 14.3 0.3 0.044 14.3 0.3 1.6 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 KOO34882.1 - 0.055 13.7 0.4 0.19 11.9 0.2 2.0 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KOO34882.1 - 0.056 13.5 1.2 0.1 12.6 0.2 1.9 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KOO34882.1 - 0.063 13.4 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOO34882.1 - 0.071 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOO34882.1 - 0.08 12.7 4.1 2 8.1 2.2 2.5 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KOO34882.1 - 0.085 12.6 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ResIII PF04851.15 KOO34882.1 - 0.09 12.8 1.7 3.6 7.5 1.7 2.3 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 KOO34882.1 - 0.18 12.4 0.5 0.8 10.3 0.1 2.3 2 1 0 2 2 2 0 AAA domain AAA_2 PF07724.14 KOO34882.1 - 0.22 11.6 2.9 0.48 10.5 0.3 2.7 1 1 1 3 3 3 0 AAA domain (Cdc48 subfamily) Scramblase PF03803.15 KOO34883.1 - 5.7e-27 94.5 0.0 1.9e-26 92.8 0.0 1.7 1 1 0 1 1 1 1 Scramblase S-AdoMet_synt_C PF02773.16 KOO34884.1 - 3.2e-60 202.1 0.0 5.2e-60 201.4 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 KOO34884.1 - 8.8e-38 129.2 0.0 4.8e-37 126.9 0.0 2.1 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 KOO34884.1 - 5e-36 123.4 0.3 9.4e-36 122.5 0.3 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain Amdase PF17645.1 KOO34884.1 - 0.13 11.9 0.0 2 8.0 0.0 2.1 2 0 0 2 2 2 0 Arylmalonate decarboxylase Fez1 PF06818.15 KOO34885.1 - 1.1 9.7 8.8 0.21 12.0 2.8 2.0 2 0 0 2 2 2 0 Fez1 Pkinase PF00069.25 KOO34886.1 - 0.0066 15.8 0.0 0.0066 15.8 0.0 3.8 2 1 0 2 2 2 1 Protein kinase domain DUF4573 PF15140.6 KOO34886.1 - 0.082 12.7 16.4 0.019 14.8 9.5 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4573) DSBA PF01323.20 KOO34886.1 - 0.4 10.4 11.5 0.96 9.2 11.3 1.7 1 1 0 1 1 1 0 DSBA-like thioredoxin domain adh_short PF00106.25 KOO34888.1 - 1.7e-11 43.9 0.7 1.7e-05 24.4 0.0 2.5 2 0 0 2 2 2 2 short chain dehydrogenase TPT PF03151.16 KOO34888.1 - 2.9e-10 40.0 17.4 3.8e-10 39.6 17.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family adh_short_C2 PF13561.6 KOO34888.1 - 5.3e-07 29.4 1.5 8.4e-06 25.5 0.1 2.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase UAA PF08449.11 KOO34888.1 - 1.5e-06 27.7 15.7 3.1e-06 26.6 15.7 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO34888.1 - 0.00034 20.8 31.3 0.012 15.7 10.6 2.3 2 0 0 2 2 2 2 EamA-like transporter family COX14 PF14880.6 KOO34888.1 - 0.024 14.5 0.0 0.094 12.6 0.0 2.0 1 0 0 1 1 1 0 Cytochrome oxidase c assembly DUF4017 PF13209.6 KOO34888.1 - 0.87 9.6 5.9 3.3 7.7 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4017) TFIIE_beta PF02186.15 KOO34890.1 - 3.1e-08 33.8 0.0 7.6e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 TFIIE beta subunit core domain Nuc_rec_co-act PF08815.10 KOO34890.1 - 0.0032 17.3 0.5 0.0066 16.3 0.5 1.5 1 0 0 1 1 1 1 Nuclear receptor coactivator FAM76 PF16046.5 KOO34890.1 - 0.071 12.5 5.6 0.064 12.6 0.4 2.0 2 0 0 2 2 2 0 FAM76 protein CdiI_2 PF18593.1 KOO34890.1 - 0.12 13.0 0.2 0.39 11.4 0.2 1.8 1 0 0 1 1 1 0 CdiI immunity protein TPR_2 PF07719.17 KOO34891.1 - 3.4e-05 23.6 2.8 4.7 7.6 0.1 5.1 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO34891.1 - 0.014 15.2 0.6 58 3.7 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO34891.1 - 3.1 8.2 9.6 13 6.1 0.8 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO34891.1 - 7.5 7.5 19.3 7.3 7.5 1.4 6.0 4 0 0 4 4 4 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 KOO34892.1 - 1.8e-12 45.8 0.8 1.8e-05 23.9 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO34892.1 - 2.3e-10 39.5 0.1 0.00024 20.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO34892.1 - 7e-09 36.0 0.1 1e-08 35.5 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO34892.1 - 3.3e-07 30.0 0.1 0.00092 19.0 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO34892.1 - 1.5e-06 27.4 0.1 0.00033 20.0 0.0 2.3 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 KOO34892.1 - 0.068 13.5 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region MBOAT PF03062.19 KOO34894.1 - 1.1e-32 113.8 12.3 1.3e-32 113.5 11.8 1.3 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF997 PF06196.12 KOO34894.1 - 0.36 10.9 11.9 1.5 8.9 1.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF997) ABC_tran PF00005.27 KOO34895.1 - 2.1e-09 38.0 0.4 1.2e-08 35.6 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ABC_tran_CTD PF16326.5 KOO34895.1 - 0.00027 21.1 6.0 0.00027 21.1 6.0 1.7 2 0 0 2 2 2 1 ABC transporter C-terminal domain AAA_21 PF13304.6 KOO34895.1 - 0.0088 15.9 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Amidohydro_2 PF04909.14 KOO34895.1 - 0.081 12.7 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Amidohydrolase Pro_CA PF00484.19 KOO34896.1 - 2.1e-11 44.4 0.4 1e-10 42.2 0.0 1.9 2 0 0 2 2 2 1 Carbonic anhydrase PWWP PF00855.17 KOO34898.1 - 1.1e-11 45.0 0.4 1.1e-11 45.0 0.4 2.9 2 1 0 2 2 2 1 PWWP domain Chromo PF00385.24 KOO34898.1 - 4e-10 39.5 0.0 9.1e-10 38.3 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CAF1A PF12253.8 KOO34898.1 - 5.7e-08 32.8 0.8 5.7e-08 32.8 0.8 3.7 3 0 0 3 3 3 1 Chromatin assembly factor 1 subunit A KHA PF11834.8 KOO34898.1 - 9.5e-08 32.0 0.0 1.9e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel TEX19 PF15553.6 KOO34898.1 - 0.02 14.9 0.6 0.02 14.9 0.6 3.2 4 1 1 5 5 5 0 Testis-expressed protein 19 LRR_6 PF13516.6 KOO34899.1 - 7.3e-10 38.1 1.0 0.043 13.9 0.0 5.2 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 KOO34899.1 - 0.0032 17.8 0.2 0.16 12.4 0.6 2.7 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) DUF1242 PF06842.12 KOO34899.1 - 0.048 13.5 0.5 3.6 7.5 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1242) LRR_8 PF13855.6 KOO34899.1 - 0.14 11.9 0.2 4.1 7.3 0.5 2.8 2 1 0 2 2 2 0 Leucine rich repeat ODR4-like PF14778.6 KOO34900.1 - 1.9e-33 116.0 0.0 2.4e-33 115.6 0.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 4-like RNA_capsid PF03035.14 KOO34902.1 - 0.028 14.5 2.4 0.032 14.2 2.4 1.1 1 0 0 1 1 1 0 Calicivirus putative RNA polymerase/capsid protein EF-hand_7 PF13499.6 KOO34903.1 - 1.1e-07 32.2 0.0 0.0028 18.1 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO34903.1 - 2e-06 27.3 0.2 0.21 11.6 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KOO34903.1 - 3.2e-06 26.4 0.0 0.064 12.8 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 KOO34903.1 - 0.00014 21.2 0.5 4.7 7.0 0.0 4.6 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 KOO34903.1 - 0.00069 19.4 0.2 0.93 9.4 0.0 3.8 4 0 0 4 4 4 1 EF-hand domain pair PT PF04886.12 KOO34903.1 - 7.8 6.1 20.4 6.8 6.3 0.6 2.7 2 0 0 2 2 2 0 PT repeat TFIIA PF03153.13 KOO34905.1 - 0.83 9.6 10.3 1 9.3 10.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF572 PF04502.13 KOO34905.1 - 3.2 7.3 13.1 4.4 6.8 13.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) UCH PF00443.29 KOO34906.1 - 2.8e-19 69.6 0.0 4.2e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO34906.1 - 0.00023 20.9 0.0 0.00041 20.0 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase EF-hand_5 PF13202.6 KOO34907.1 - 0.0037 16.7 0.0 0.0073 15.8 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO34907.1 - 0.029 13.9 0.0 0.057 13.0 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 KOO34907.1 - 0.097 12.6 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 KOO34907.1 - 0.17 12.4 0.1 0.6 10.6 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair AAA_34 PF13872.6 KOO34908.1 - 1e-106 356.3 0.0 1.5e-106 355.8 0.0 1.2 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 KOO34908.1 - 2e-96 322.8 1.1 3.4e-96 322.1 1.1 1.4 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue Dimer_Tnp_hAT PF05699.14 KOO34909.1 - 6.1e-11 42.0 0.0 8.5e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region LRR_5 PF13306.6 KOO34911.1 - 9.1e-96 316.6 0.0 3.2e-36 124.1 0.0 3.2 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO34911.1 - 4.7e-22 77.5 0.0 0.034 13.9 0.0 8.0 2 1 8 10 10 10 9 Leucine rich repeat Adeno_E1B_55K PF01696.17 KOO34911.1 - 0.045 12.4 0.4 0.093 11.4 0.4 1.5 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen Peptidase_S8 PF00082.22 KOO34912.1 - 2.2e-18 66.6 1.0 3.9e-18 65.7 1.0 1.4 1 0 0 1 1 1 1 Subtilase family Peptidase_C69 PF03577.15 KOO34912.1 - 2.6e-09 36.5 0.0 4e-08 32.6 0.0 2.2 1 1 0 1 1 1 1 Peptidase family C69 P_proprotein PF01483.20 KOO34912.1 - 2.2e-07 30.8 0.1 1.1e-06 28.5 0.0 2.1 2 0 0 2 2 2 1 Proprotein convertase P-domain Syja_N PF02383.18 KOO34913.1 - 1.5e-49 169.0 0.0 9.8e-49 166.4 0.0 1.9 2 0 0 2 2 2 1 SacI homology domain DUF1978 PF09321.10 KOO34913.1 - 0.23 10.8 0.0 0.43 9.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) HEAT_2 PF13646.6 KOO34913.1 - 0.3 11.5 8.1 7.1 7.1 0.1 4.2 4 0 0 4 4 4 0 HEAT repeats PAP_fibrillin PF04755.12 KOO34914.1 - 1.5e-08 34.8 0.0 0.00038 20.5 0.0 2.2 2 0 0 2 2 2 2 PAP_fibrillin Sel1 PF08238.12 KOO34915.1 - 0.00037 21.1 0.7 0.0016 19.0 0.0 2.5 3 0 0 3 3 3 1 Sel1 repeat Torus PF16131.5 KOO34916.1 - 1.5e-10 41.7 0.0 2.5e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Torus domain WW PF00397.26 KOO34916.1 - 3.4e-08 33.4 1.1 6.2e-08 32.6 1.1 1.5 1 0 0 1 1 1 1 WW domain DUF1501 PF07394.12 KOO34918.1 - 4.2e-41 141.3 0.0 6.7e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) DUF1800 PF08811.11 KOO34918.1 - 5.1e-21 75.2 0.0 8.3e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1800) AAA_6 PF12774.7 KOO34920.1 - 6.1e-77 258.8 0.1 8.2e-77 258.3 0.1 1.1 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region WD40 PF00400.32 KOO34921.1 - 8.6e-08 32.7 6.3 0.069 14.0 0.4 5.2 6 0 0 6 6 6 2 WD domain, G-beta repeat PQQ_3 PF13570.6 KOO34921.1 - 0.00049 20.5 0.4 2.3 8.8 0.0 3.8 4 0 0 4 4 4 2 PQQ-like domain LRR_6 PF13516.6 KOO34922.1 - 7.5e-18 63.0 20.5 0.0034 17.3 0.2 9.8 10 0 0 10 10 10 6 Leucine Rich repeat LRR_4 PF12799.7 KOO34922.1 - 5.7e-06 26.6 0.5 0.68 10.4 0.1 4.7 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) Metal_CEHH PF14455.6 KOO34922.1 - 0.00031 20.4 0.2 0.11 12.1 0.0 3.1 1 1 2 3 3 3 1 Predicted metal binding domain LRR_1 PF00560.33 KOO34922.1 - 0.0028 18.0 0.0 1.5e+02 3.6 0.0 5.6 7 0 0 7 7 7 0 Leucine Rich Repeat FIBP PF05427.11 KOO34922.1 - 0.1 11.9 0.1 3.8 6.7 0.0 2.1 2 0 0 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) SpoU_sub_bind PF08032.12 KOO34922.1 - 0.15 12.3 0.0 51 4.2 0.0 3.5 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding PH PF00169.29 KOO34923.1 - 4.5e-11 43.2 0.0 7.5e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 PH domain Gelsolin PF00626.22 KOO34923.1 - 6.8e-06 25.9 0.0 0.0018 18.1 0.0 2.4 2 0 0 2 2 2 2 Gelsolin repeat PH_11 PF15413.6 KOO34923.1 - 0.11 12.9 0.1 0.21 12.1 0.1 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Pkinase PF00069.25 KOO34924.1 - 3.2e-21 75.9 0.0 7.2e-21 74.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34924.1 - 4.6e-20 72.0 0.1 3.3e-19 69.2 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 KOO34924.1 - 0.0018 18.0 0.0 0.19 11.3 0.0 2.1 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 CBM_14 PF01607.24 KOO34925.1 - 0.038 14.2 0.5 0.091 12.9 0.1 1.7 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain SBBP PF06739.11 KOO34927.1 - 1.7e-14 53.5 37.0 0.0016 18.4 2.0 7.1 7 0 0 7 7 7 5 Beta-propeller repeat Glyco_hydro_42M PF08532.10 KOO34927.1 - 9.2 5.7 8.2 50 3.3 0.3 3.5 3 0 0 3 3 3 0 Beta-galactosidase trimerisation domain PHO4 PF01384.20 KOO34928.1 - 8.4e-105 350.5 11.5 1.1e-104 350.1 11.5 1.1 1 0 0 1 1 1 1 Phosphate transporter family SDP_N PF12278.8 KOO34928.1 - 0.065 13.4 1.3 0.1 12.7 1.3 1.2 1 0 0 1 1 1 0 Sex determination protein N terminal Spc7 PF08317.11 KOO34929.1 - 0.065 12.1 7.6 0.095 11.6 7.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 KOO34929.1 - 0.11 12.6 3.0 0.17 12.0 3.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus MRP-S26 PF14943.6 KOO34929.1 - 0.36 10.7 5.3 0.72 9.8 5.3 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Atg14 PF10186.9 KOO34929.1 - 2.6 7.0 8.1 3.6 6.6 8.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Pkinase PF00069.25 KOO34930.1 - 9.7e-44 149.7 0.0 1.3e-43 149.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34930.1 - 2.4e-20 72.9 0.0 4.9e-19 68.6 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO34930.1 - 0.00025 20.4 0.1 0.00042 19.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOO34930.1 - 0.012 14.6 0.0 0.015 14.2 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KOO34930.1 - 0.013 15.4 0.2 0.013 15.4 0.2 2.7 3 1 1 4 4 4 0 Phosphotransferase enzyme family Cdd1 PF11731.8 KOO34930.1 - 0.073 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Pathogenicity locus SPX PF03105.19 KOO34932.1 - 1.8e-16 61.1 2.9 1e-09 38.9 0.7 3.1 1 1 2 3 3 3 2 SPX domain CENP-S PF15630.6 KOO34932.1 - 0.05 14.0 0.0 0.094 13.1 0.0 1.3 1 0 0 1 1 1 0 CENP-S protein Chloroa_b-bind PF00504.21 KOO34933.1 - 4.2e-34 118.4 0.1 8.4e-34 117.4 0.0 1.5 2 0 0 2 2 2 1 Chlorophyll A-B binding protein TBCC PF07986.12 KOO34934.1 - 2.9e-20 72.2 2.8 4.2e-20 71.7 2.8 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 KOO34934.1 - 0.12 12.0 0.5 0.19 11.4 0.5 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal LRR_6 PF13516.6 KOO34935.1 - 4.9e-18 63.6 42.6 0.031 14.3 0.1 17.8 19 0 0 19 19 19 4 Leucine Rich repeat LRR_1 PF00560.33 KOO34935.1 - 0.00034 20.7 5.6 81 4.4 0.0 8.5 10 0 0 10 10 10 0 Leucine Rich Repeat SIN1 PF05422.12 KOO34935.1 - 0.016 15.7 0.0 23 5.6 0.0 3.5 3 0 0 3 3 3 0 Stress-activated map kinase interacting protein 1 (SIN1) OAR PF03826.17 KOO34935.1 - 0.14 12.0 3.4 82 3.2 0.0 4.3 4 0 0 4 4 4 0 OAR domain LRR_8 PF13855.6 KOO34935.1 - 2.2 8.1 12.2 34 4.3 0.1 6.3 8 0 0 8 8 8 0 Leucine rich repeat Lipoprotein_1 PF00820.19 KOO34935.1 - 4.6 6.2 5.6 16 4.4 0.5 2.3 2 0 0 2 2 2 0 Borrelia lipoprotein Tic110 PF16940.5 KOO34937.1 - 5.7e-09 35.0 2.5 3e-05 22.7 1.7 3.3 3 1 0 3 3 3 2 Chloroplast envelope transporter DIE2_ALG10 PF04922.12 KOO34938.1 - 2.8e-70 237.6 1.0 3.5e-70 237.3 1.0 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family DUF563 PF04577.14 KOO34939.1 - 3.7e-19 69.7 0.0 4.8e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Hydrolase PF00702.26 KOO34940.1 - 4.3e-05 23.9 0.0 7.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOO34940.1 - 0.012 15.7 0.0 0.031 14.4 0.0 1.7 1 1 0 1 1 1 0 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KOO34941.1 - 2e-17 63.3 0.0 1.6e-14 53.9 0.0 2.5 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_N PF00690.26 KOO34941.1 - 0.00015 21.4 0.0 0.00033 20.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus TPR_1 PF00515.28 KOO34942.1 - 2e-17 62.2 9.4 6.5e-06 25.7 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO34942.1 - 1.9e-12 46.6 5.6 0.00026 20.6 0.4 4.3 3 2 2 5 5 5 3 TPR repeat TPR_17 PF13431.6 KOO34942.1 - 4.2e-12 45.5 2.8 0.0002 21.5 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO34942.1 - 6e-12 44.8 7.2 0.0019 18.3 0.1 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO34942.1 - 7.5e-10 38.2 16.8 0.00012 21.9 0.1 5.3 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO34942.1 - 1.5e-08 35.1 11.6 6.4e-05 23.5 4.5 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO34942.1 - 4.7e-08 33.2 10.7 0.0044 17.3 1.7 4.9 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO34942.1 - 3e-07 30.7 12.2 0.0044 17.7 0.2 5.5 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO34942.1 - 1.5e-06 27.9 10.0 0.016 15.0 0.1 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO34942.1 - 1.9e-05 25.0 7.7 0.0016 18.9 4.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO34942.1 - 0.00018 21.3 8.0 0.0047 16.9 0.3 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.6 KOO34942.1 - 0.00033 20.9 0.6 0.086 13.2 0.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_3 PF07720.12 KOO34942.1 - 0.004 17.1 0.1 1.2 9.2 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO34942.1 - 0.013 14.7 0.6 0.022 14.0 0.6 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO34942.1 - 0.024 15.2 2.9 0.35 11.6 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat SRP1_TIP1 PF00660.17 KOO34942.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Seripauperin and TIP1 family TPR_9 PF13371.6 KOO34942.1 - 0.54 10.4 4.0 4.9 7.4 1.5 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.25 KOO34943.1 - 1.7e-29 103.0 0.0 1.9e-24 86.5 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34943.1 - 1.3e-13 50.9 0.0 3.2e-08 33.2 0.0 2.6 2 1 0 3 3 3 2 Protein tyrosine kinase FTA2 PF13095.6 KOO34943.1 - 4.8e-06 26.3 0.0 0.033 13.8 0.0 2.1 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 KOO34943.1 - 0.00073 18.9 0.0 0.0043 16.4 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 KOO34943.1 - 0.0034 16.8 0.1 0.007 15.7 0.0 1.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO34943.1 - 0.044 12.6 0.0 0.059 12.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 KOO34943.1 - 0.097 12.6 0.0 0.21 11.5 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 KOO34943.1 - 0.19 11.3 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Histone PF00125.24 KOO34945.1 - 3.9e-54 182.5 2.0 4.4e-54 182.4 2.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KOO34945.1 - 0.00012 22.2 0.3 0.00022 21.3 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 KOO34945.1 - 0.00023 21.7 1.5 0.00028 21.5 1.5 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 KOO34945.1 - 0.00036 20.8 0.0 0.00055 20.3 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 KOO34945.1 - 0.0032 17.7 0.0 0.0062 16.8 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KOO34945.1 - 0.11 12.6 0.1 0.22 11.6 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Ribosomal_S19 PF00203.21 KOO34946.1 - 1.4e-29 101.8 0.1 1.9e-29 101.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 FliH PF02108.16 KOO34946.1 - 0.058 13.5 0.0 0.076 13.1 0.0 1.1 1 0 0 1 1 1 0 Flagellar assembly protein FliH DNA_pol_A PF00476.20 KOO34947.1 - 4.2e-17 62.3 0.4 1.2e-11 44.3 0.0 2.0 1 1 1 2 2 2 2 DNA polymerase family A DNA_pol_A PF00476.20 KOO34948.1 - 1.2e-05 24.6 0.0 0.0087 15.1 0.1 2.0 2 0 0 2 2 2 2 DNA polymerase family A Herpes_IE68 PF02479.16 KOO34948.1 - 0.071 12.7 0.0 0.083 12.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus immediate early protein Kinesin PF00225.23 KOO34950.1 - 1.2e-82 277.5 0.0 1.5e-82 277.2 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO34950.1 - 6.6e-18 65.1 0.0 1e-16 61.2 0.0 2.2 1 1 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 KOO34950.1 - 0.046 14.1 0.0 0.1 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain PUB PF09409.10 KOO34952.1 - 5.6e-13 48.6 0.0 1.4e-11 44.2 0.0 2.8 3 0 0 3 3 3 1 PUB domain UBA PF00627.31 KOO34952.1 - 1.8e-08 34.1 0.0 1.8e-08 34.1 0.0 3.1 3 0 0 3 3 3 1 UBA/TS-N domain CH PF00307.31 KOO34953.1 - 4.9e-26 91.1 0.0 3.4e-17 62.6 0.1 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain MFS_1 PF07690.16 KOO34954.1 - 6.2e-08 32.0 38.0 7.1e-08 31.8 18.5 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily HMG_box PF00505.19 KOO34955.1 - 3.8e-05 24.0 0.1 0.00011 22.6 0.1 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOO34955.1 - 0.0025 18.4 0.0 0.0059 17.2 0.0 1.6 1 0 0 1 1 1 1 HMG-box domain CDC45 PF02724.14 KOO34955.1 - 0.58 8.4 2.1 0.8 7.9 2.1 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 KOO34955.1 - 4.3 6.6 9.4 6.3 6.0 9.4 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 KOO34955.1 - 9.4 6.7 12.2 19 5.7 12.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain MMPL PF03176.15 KOO34956.1 - 1.5 7.7 6.1 3 6.7 6.1 1.4 1 0 0 1 1 1 0 MMPL family IQ PF00612.27 KOO34957.1 - 0.00055 19.5 1.7 0.00094 18.8 1.3 8.3 8 0 0 8 8 8 3 IQ calmodulin-binding motif DUF4878 PF12870.7 KOO34957.1 - 0.019 15.2 0.8 0.064 13.6 0.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4878) PP2C PF00481.21 KOO34959.1 - 3.7e-41 141.5 0.0 5e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO34959.1 - 0.00034 20.3 0.9 0.0019 17.9 0.9 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C CheY-binding PF09078.11 KOO34959.1 - 0.17 12.0 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 CheY binding Lsm_C PF14894.6 KOO34960.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Lsm C-terminal EutB PF06751.11 KOO34962.1 - 0.00033 19.6 2.5 0.00033 19.6 2.5 1.6 2 0 0 2 2 2 1 Ethanolamine ammonia lyase large subunit (EutB) UPF0016 PF01169.19 KOO34964.1 - 4.5e-43 145.5 21.9 5.3e-22 77.9 4.9 2.4 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 TerC PF03741.16 KOO34964.1 - 0.00051 19.8 2.6 0.00051 19.8 2.6 2.1 2 0 0 2 2 2 1 Integral membrane protein TerC family HXXEE PF13787.6 KOO34964.1 - 0.02 15.7 1.9 0.2 12.5 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif LodA_C PF18417.1 KOO34964.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 L-lysine epsilon oxidase C-terminal domain DUF373 PF04123.13 KOO34964.1 - 3.1 7.2 5.8 1.4 8.3 0.4 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF373) Mur_ligase_M PF08245.12 KOO34965.1 - 1.5e-05 25.1 0.0 3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 KOO34965.1 - 0.00015 22.0 0.0 0.00056 20.1 0.0 2.0 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Myb_DNA-binding PF00249.31 KOO34966.1 - 1.2e-26 92.6 1.9 1.5e-12 47.5 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO34966.1 - 5.9e-17 61.7 0.9 1.2e-07 31.9 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO34966.1 - 1.2e-05 25.1 0.0 0.086 12.7 0.0 2.4 2 0 0 2 2 2 2 Myb DNA-binding like SLIDE PF09111.10 KOO34966.1 - 0.0036 17.3 0.0 0.14 12.1 0.0 2.3 2 0 0 2 2 2 1 SLIDE Pkinase PF00069.25 KOO34967.1 - 2.7e-25 89.2 0.0 4.2e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34967.1 - 4.6e-24 85.1 0.0 6.3e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 KOO34967.1 - 0.038 13.6 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 RIO1 family SRP_SPB PF02978.19 KOO34967.1 - 0.057 14.0 0.0 0.2 12.3 0.0 1.8 2 0 0 2 2 2 0 Signal peptide binding domain Pkinase_fungal PF17667.1 KOO34967.1 - 0.16 10.7 0.0 0.23 10.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Pkinase_Tyr PF07714.17 KOO34968.1 - 2.1e-48 164.9 0.0 3e-48 164.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO34968.1 - 1.2e-37 129.8 0.0 1.8e-37 129.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain p450 PF00067.22 KOO34968.1 - 2.6e-09 36.3 0.0 3.9e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Kinase-like PF14531.6 KOO34968.1 - 0.0011 18.4 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Tmemb_40 PF10160.9 KOO34968.1 - 0.016 14.7 7.0 0.037 13.5 7.0 1.6 1 0 0 1 1 1 0 Predicted membrane protein APH PF01636.23 KOO34968.1 - 0.018 15.0 0.0 0.052 13.5 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family DEC-1_N PF04625.13 KOO34969.1 - 0.14 11.2 2.8 0.17 10.9 2.8 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Rieske PF00355.26 KOO34970.1 - 6.2e-13 48.5 0.0 9.5e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain AP2 PF00847.20 KOO34974.1 - 0.012 15.8 0.0 0.012 15.8 0.0 3.5 6 0 0 6 6 6 0 AP2 domain IF3_N PF05198.16 KOO34974.1 - 0.18 12.1 0.2 26 5.2 0.1 2.8 2 1 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain Myosin_N PF02736.19 KOO34974.1 - 0.2 11.5 0.0 1.3 8.9 0.1 2.0 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain Tom5 PF10642.9 KOO34974.1 - 4 7.5 6.3 69 3.6 0.2 3.7 3 0 0 3 3 3 0 Mitochondrial import receptor subunit or translocase YcaO PF02624.16 KOO34974.1 - 8 5.6 12.7 28 3.9 0.1 2.8 2 1 1 3 3 3 0 YcaO cyclodehydratase, ATP-ad Mg2+-binding zf-CCCH_4 PF18044.1 KOO34976.1 - 0.094 12.5 5.3 0.32 10.8 5.3 1.9 1 1 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOO34976.1 - 0.16 12.1 4.1 5.1 7.3 4.1 2.4 1 1 0 1 1 1 0 Zinc finger domain Nkap_C PF06047.11 KOO34978.1 - 5.8e-44 148.4 2.2 8.3e-44 147.9 2.2 1.2 1 0 0 1 1 1 1 NF-kappa-B-activating protein C-terminal domain DnaJ PF00226.31 KOO34979.1 - 7.8e-21 74.0 0.1 1.3e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Sigma70_ner PF04546.13 KOO34979.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region ELF PF03317.13 KOO34979.1 - 0.09 12.8 0.0 0.48 10.4 0.0 1.9 2 0 0 2 2 2 0 ELF protein Mito_carr PF00153.27 KOO34980.1 - 1.3e-31 108.3 8.6 1.1e-14 54.1 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PT-VENN PF04829.13 KOO34980.1 - 0.13 12.4 1.0 0.6 10.2 1.0 2.2 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif Pentapeptide_4 PF13599.6 KOO34981.1 - 5.8e-12 45.6 0.0 0.0079 16.3 0.1 7.4 6 2 1 7 7 7 3 Pentapeptide repeats (9 copies) XK-related PF09815.9 KOO34981.1 - 0.0021 17.2 11.2 0.039 13.0 11.2 2.1 1 1 0 1 1 1 1 XK-related protein SinI PF08671.10 KOO34981.1 - 1.5 8.6 8.5 3.7 7.4 0.0 5.6 8 0 0 8 8 8 0 Anti-repressor SinI Chloroa_b-bind PF00504.21 KOO34982.1 - 1.2e-37 130.0 0.1 1.4e-37 129.7 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein ADP_PFK_GK PF04587.15 KOO34984.1 - 0.062 11.9 1.2 0.09 11.3 1.2 1.2 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region BshC PF10079.9 KOO34984.1 - 1.8 7.2 5.7 1.1 7.9 0.5 2.0 2 0 0 2 2 2 0 Bacillithiol biosynthesis BshC MRP-S31 PF15433.6 KOO34984.1 - 6.4 6.4 9.8 0.56 9.8 1.2 2.1 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 Pkinase PF00069.25 KOO34986.1 - 6.8e-07 28.9 0.3 2.5e-06 27.1 0.2 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO34986.1 - 3.1e-06 26.6 0.1 9.1e-06 25.1 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO34986.1 - 0.04 13.8 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOO34986.1 - 0.051 13.2 0.4 0.2 11.2 0.4 2.0 1 1 0 1 1 1 0 Choline/ethanolamine kinase OrfB_IS605 PF01385.19 KOO34986.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Probable transposase TPT PF03151.16 KOO34987.1 - 2e-06 27.4 6.5 2e-06 27.4 6.5 2.3 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 KOO34987.1 - 0.00014 22.0 8.2 0.00014 22.0 8.2 2.5 2 1 0 2 2 2 1 EamA-like transporter family Ank_5 PF13857.6 KOO34989.1 - 2.8e-11 43.4 0.1 8.6e-06 25.9 0.0 3.3 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO34989.1 - 1.1e-09 38.7 0.3 3.7e-05 24.2 0.0 3.7 3 2 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO34989.1 - 1.1e-06 29.1 0.0 0.056 14.0 0.0 3.1 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO34989.1 - 0.00018 21.7 0.1 1.4 9.7 0.0 4.0 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 KOO34989.1 - 0.00025 21.3 0.0 0.73 10.4 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeat Inhibitor_I53 PF11714.8 KOO34989.1 - 0.73 10.1 3.6 6.5 7.0 0.5 2.4 1 1 1 2 2 2 0 Thrombin inhibitor Madanin PIP5K PF01504.18 KOO34990.1 - 4.5e-40 137.6 0.0 1.5e-39 135.9 0.0 1.7 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase ART PF01129.18 KOO34991.1 - 4.7e-11 42.4 0.0 6.5e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Myosin_head PF00063.21 KOO34993.1 - 4.8e-16 58.1 0.0 1.1e-07 30.5 0.0 2.3 2 0 0 2 2 2 2 Myosin head (motor domain) Mem_trans PF03547.18 KOO34993.1 - 4e-08 32.1 0.1 1.3e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 Membrane transport protein TMEM144 PF07857.12 KOO34993.1 - 1.1e-07 31.2 10.8 1.7e-07 30.6 10.8 1.3 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters LRR_6 PF13516.6 KOO34993.1 - 1.1e-06 28.2 0.1 0.073 13.2 0.0 3.8 3 0 0 3 3 3 2 Leucine Rich repeat Sugar_transport PF06800.12 KOO34993.1 - 3.3e-05 23.4 1.7 3.3e-05 23.4 1.7 3.2 3 0 0 3 3 3 1 Sugar transport protein Beta-lactamase PF00144.24 KOO34994.1 - 3.5e-19 69.2 0.2 6.4e-19 68.4 0.2 1.3 1 0 0 1 1 1 1 Beta-lactamase AAT PF03417.16 KOO34995.1 - 2.6e-11 43.6 0.0 5.6e-11 42.6 0.0 1.4 1 1 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase GPS2_interact PF15784.5 KOO34997.1 - 0.16 12.4 0.0 0.28 11.7 0.0 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain RCC1 PF00415.18 KOO34998.1 - 3.1e-19 69.3 7.9 7.9e-09 36.0 0.1 4.4 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO34998.1 - 1.3e-14 53.6 18.3 4.5e-08 32.7 0.6 4.0 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat DUF4575 PF15143.6 KOO34999.1 - 0.0066 16.7 3.3 0.0066 16.7 3.3 5.7 4 1 2 6 6 6 3 Domain of unknown function (DUF4575) DAZAP2 PF11029.8 KOO34999.1 - 5.3 8.0 17.7 7.9 7.4 0.1 4.0 4 0 0 4 4 4 0 DAZ associated protein 2 (DAZAP2) DSHCT PF08148.12 KOO35001.1 - 2.4e-37 128.2 0.3 3.5e-37 127.6 0.3 1.2 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 KOO35002.1 - 3.8e-15 56.1 0.0 5.7e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO35002.1 - 4.8e-05 23.4 0.0 8.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOO35002.1 - 0.0071 16.6 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Guanylate_kin PF00625.21 KOO35003.1 - 4.3e-57 192.7 0.0 4.9e-57 192.5 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 KOO35003.1 - 1.9e-05 24.8 0.0 0.00039 20.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KOO35003.1 - 0.00067 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 KOO35003.1 - 0.0021 18.3 0.0 0.0044 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO35003.1 - 0.0044 17.4 0.0 0.0066 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 KOO35003.1 - 0.016 15.8 0.4 0.086 13.4 0.4 2.0 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOO35003.1 - 0.026 14.0 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region HopW1-1 PF15457.6 KOO35003.1 - 0.053 12.8 0.0 0.064 12.5 0.0 1.1 1 0 0 1 1 1 0 Type III T3SS secreted effector HopW1-1/HopPmaA MMR_HSR1 PF01926.23 KOO35003.1 - 0.066 13.3 0.0 0.085 12.9 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATPase_2 PF01637.18 KOO35003.1 - 0.085 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Roc PF08477.13 KOO35003.1 - 0.097 12.9 0.1 0.25 11.5 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 KOO35003.1 - 0.11 12.3 0.2 1.1 9.1 0.0 2.5 2 1 1 3 3 3 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 KOO35003.1 - 0.13 12.7 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TniB PF05621.11 KOO35003.1 - 0.2 11.0 0.0 0.44 9.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Rad17 PF03215.15 KOO35003.1 - 0.22 11.4 0.0 0.34 10.8 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain Helicase_C PF00271.31 KOO35004.1 - 0.00013 22.2 0.0 0.00031 21.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain rRNA_proc-arch PF13234.6 KOO35004.1 - 0.0072 16.3 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 rRNA-processing arch domain DUF3516 PF12029.8 KOO35004.1 - 0.26 10.3 0.0 0.38 9.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) 2OG-FeII_Oxy_3 PF13640.6 KOO35005.1 - 0.058 14.3 0.0 0.13 13.2 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily BAG PF02179.16 KOO35006.1 - 0.033 14.6 0.2 0.12 12.8 0.2 1.9 1 0 0 1 1 1 0 BAG domain DUF3638 PF12340.8 KOO35007.1 - 1.7e-33 115.9 0.0 4.2e-33 114.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) Thioredoxin_8 PF13905.6 KOO35007.1 - 1e-28 99.5 0.0 6.1e-22 77.8 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like DUF3645 PF12359.8 KOO35007.1 - 2e-14 52.7 0.2 7.3e-12 44.5 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3645) AhpC-TSA PF00578.21 KOO35007.1 - 0.00026 20.9 0.0 0.00087 19.2 0.0 1.9 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.20 KOO35007.1 - 0.00046 20.1 0.0 0.0032 17.4 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin Redoxin PF08534.10 KOO35007.1 - 0.0023 17.7 0.0 0.0074 16.0 0.0 1.9 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 KOO35007.1 - 0.0076 16.7 0.0 0.029 14.8 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain Laminin_G_3 PF13385.6 KOO35007.1 - 0.014 15.5 0.0 0.033 14.4 0.0 1.5 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily DUF1681 PF07933.14 KOO35008.1 - 4.9e-44 149.6 0.0 6.5e-44 149.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Mito_fiss_reg PF05308.11 KOO35009.1 - 0.23 11.5 5.2 0.072 13.2 1.8 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator SAM_1 PF00536.30 KOO35010.1 - 6.4e-25 87.4 0.3 5.6e-11 42.7 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO35010.1 - 3.1e-24 84.9 0.1 6.8e-11 42.1 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 KOO35010.1 - 0.0039 17.1 0.3 0.077 13.0 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DERM PF14704.6 KOO35010.1 - 0.0061 17.1 0.8 0.013 16.0 0.8 1.6 1 1 0 1 1 1 1 Dermatopontin SAM_PNT PF02198.16 KOO35010.1 - 0.028 14.4 0.3 2.4 8.2 0.0 2.9 2 2 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain CNOT11 PF10155.9 KOO35011.1 - 7.3e-54 181.2 5.9 7.3e-54 181.2 5.9 1.5 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 11 Creb_binding PF09030.10 KOO35011.1 - 0.086 13.5 0.0 0.28 11.9 0.0 1.8 1 0 0 1 1 1 0 Creb binding Ribosomal_S27e PF01667.17 KOO35012.1 - 7e-29 99.3 6.9 8.6e-29 99.0 6.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.21 KOO35012.1 - 0.022 14.9 1.3 0.029 14.6 1.3 1.2 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-CSL PF05207.13 KOO35012.1 - 0.26 11.0 2.6 0.56 10.0 2.6 1.7 1 1 0 1 1 1 0 CSL zinc finger Nop PF01798.18 KOO35013.1 - 5.6e-66 222.3 0.0 7.7e-66 221.9 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 KOO35013.1 - 5.4e-35 120.9 3.7 5.4e-35 120.9 3.7 1.8 2 0 0 2 2 2 1 Prp31 C terminal domain IDH PF03971.14 KOO35014.1 - 0 1192.2 0.3 0 1192.1 0.3 1.0 1 0 0 1 1 1 1 Monomeric isocitrate dehydrogenase TPR_12 PF13424.6 KOO35015.1 - 2.9e-34 117.2 22.4 7.2e-12 45.4 0.9 5.7 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 KOO35015.1 - 6.2e-33 111.7 26.0 4.9e-10 39.0 0.3 7.7 7 1 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 KOO35015.1 - 2e-08 33.7 6.2 0.031 14.3 0.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO35015.1 - 2.7e-08 33.3 3.2 0.11 12.4 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO35015.1 - 1e-06 28.4 5.1 0.28 11.4 0.1 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 KOO35015.1 - 2.5e-06 27.5 29.9 0.00067 20.1 0.1 7.2 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO35015.1 - 2.6e-05 23.8 2.7 2.6e-05 23.8 2.7 2.9 1 1 1 3 3 3 2 MalT-like TPR region TPR_16 PF13432.6 KOO35015.1 - 3.6e-05 24.3 24.7 0.00059 20.4 2.4 6.1 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO35015.1 - 4.5e-05 23.9 24.0 0.0037 17.7 2.3 5.7 4 2 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO35015.1 - 0.0031 18.2 22.3 1.9 9.6 0.1 6.9 3 3 4 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO35015.1 - 0.0033 17.6 4.8 1.3 9.3 0.2 4.2 4 1 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KOO35015.1 - 0.024 14.8 0.1 4.6 7.7 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOO35015.1 - 0.076 13.4 8.6 8 7.1 0.2 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF5588 PF17826.1 KOO35015.1 - 0.32 9.8 4.0 0.4 9.5 0.0 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5588) TPR_20 PF14561.6 KOO35015.1 - 8.6 6.8 9.0 23 5.4 0.3 4.3 3 1 3 6 6 6 0 Tetratricopeptide repeat Orai-1 PF07856.12 KOO35016.1 - 0.00016 21.4 0.2 0.00031 20.5 0.2 1.4 1 0 0 1 1 1 1 Mediator of CRAC channel activity MLANA PF14991.6 KOO35016.1 - 0.033 14.5 0.0 0.033 14.5 0.0 2.9 2 1 1 3 3 3 0 Protein melan-A HC2 PF07382.11 KOO35016.1 - 4.8 7.2 126.0 0.62 10.1 69.3 2.6 1 1 1 2 2 2 0 Histone H1-like nucleoprotein HC2 Melibiase_2 PF16499.5 KOO35017.1 - 6.6e-44 150.2 0.0 8.4e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.18 KOO35017.1 - 0.0013 17.8 0.0 0.0023 17.0 0.0 1.4 1 0 0 1 1 1 1 Melibiase EF-hand_1 PF00036.32 KOO35018.1 - 2.7e-36 120.4 11.5 2.1e-05 23.7 0.0 10.6 11 0 0 11 11 11 6 EF hand EF-hand_6 PF13405.6 KOO35018.1 - 6.5e-36 119.2 12.6 5.2e-05 22.8 0.0 10.7 11 0 0 11 11 11 6 EF-hand domain EF-hand_7 PF13499.6 KOO35018.1 - 4.1e-32 110.4 11.1 6.7e-07 29.7 0.0 6.7 6 0 0 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO35018.1 - 3.6e-22 76.8 7.7 0.0014 18.1 0.1 6.9 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 KOO35018.1 - 1.6e-17 63.1 17.5 0.0014 18.5 0.0 8.1 8 1 1 9 9 9 6 EF-hand domain pair DUF4473 PF14747.6 KOO35018.1 - 0.0076 16.8 0.0 2.5 8.7 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF4473) Endonuc-dimeris PF09124.10 KOO35018.1 - 0.011 15.9 0.0 17 5.7 0.0 4.0 3 0 0 3 3 3 0 T4 recombination endonuclease VII, dimerisation DUF3885 PF13021.6 KOO35018.1 - 0.046 13.8 3.6 23 5.2 0.0 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF3885) DUF4895 PF16236.5 KOO35018.1 - 0.12 12.1 1.0 2.7 7.7 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4895) ASL_C PF08328.11 KOO35018.1 - 0.14 12.3 3.7 3.7 7.7 0.1 3.8 4 0 0 4 4 4 0 Adenylosuccinate lyase C-terminal RloB PF13707.6 KOO35018.1 - 0.88 9.7 2.9 26 5.0 0.0 3.8 5 0 0 5 5 5 0 RloB-like protein SPARC_Ca_bdg PF10591.9 KOO35018.1 - 2.3 8.6 6.6 14 6.1 0.1 4.5 4 1 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region PRCC PF10253.9 KOO35019.1 - 1.4e-09 39.0 6.5 1.4e-09 39.0 6.5 2.4 1 1 1 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting Epimerase PF01370.21 KOO35020.1 - 1e-44 152.8 0.0 1.5e-44 152.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOO35020.1 - 5.1e-24 85.3 0.0 1e-22 81.0 0.0 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 KOO35020.1 - 3.3e-10 39.4 0.0 4.7e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KOO35020.1 - 9e-10 38.7 0.0 1.3e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO35020.1 - 4.9e-06 26.3 0.0 1.1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 KOO35020.1 - 0.00036 19.8 0.0 0.042 13.0 0.0 2.7 2 1 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 KOO35020.1 - 0.0014 17.9 0.0 0.061 12.5 0.0 2.3 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 KOO35020.1 - 0.0015 17.7 0.0 0.0031 16.7 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 KOO35020.1 - 0.012 15.0 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Abhydrolase_6 PF12697.7 KOO35021.1 - 0.68 10.5 8.4 1.5 9.4 8.5 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Ins145_P3_rec PF08709.11 KOO35022.1 - 1.3e-26 93.1 0.0 1.6e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 KOO35022.1 - 0.0066 16.3 0.0 0.017 15.0 0.0 1.6 1 1 1 2 2 2 1 MIR domain ACT_3 PF10000.9 KOO35022.1 - 0.11 12.5 0.0 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 ACT domain Ribonuc_red_sm PF00268.21 KOO35023.1 - 1.4e-115 385.6 0.0 1.6e-115 385.3 0.0 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain EF-hand_1 PF00036.32 KOO35024.1 - 1.1e-18 65.3 1.0 0.0035 16.8 0.1 6.0 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO35024.1 - 2.6e-18 66.3 11.7 1.1e-05 25.8 0.2 5.0 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOO35024.1 - 2.7e-15 54.9 5.0 0.022 14.7 0.1 6.5 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 KOO35024.1 - 0.0067 16.2 7.7 4.7 7.1 0.1 4.6 4 0 0 4 4 4 2 EF-hand domain pair DUF3215 PF11503.8 KOO35024.1 - 0.062 13.2 0.0 25 4.8 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3215) Sigma_reg_C PF13791.6 KOO35024.1 - 0.077 13.2 0.1 26 5.0 0.0 3.0 3 0 0 3 3 3 0 Sigma factor regulator C-terminal HTH_3 PF01381.22 KOO35024.1 - 0.077 13.1 0.1 33 4.6 0.0 3.5 4 0 0 4 4 4 0 Helix-turn-helix EF-hand_5 PF13202.6 KOO35024.1 - 0.17 11.4 4.1 25 4.6 0.1 4.3 4 0 0 4 4 4 0 EF hand EF-hand_7 PF13499.6 KOO35025.1 - 5.2e-18 65.3 9.8 5.8e-06 26.7 0.5 5.7 4 2 0 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO35025.1 - 1.8e-15 55.2 23.3 3.3e-05 23.1 0.9 6.7 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 KOO35025.1 - 2.1e-15 55.3 15.9 6e-05 22.7 0.8 6.7 6 0 0 6 6 6 3 EF-hand domain EF-hand_5 PF13202.6 KOO35025.1 - 9.5e-11 40.7 17.9 9.4e-05 21.7 2.2 5.3 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOO35025.1 - 4.1e-08 32.9 12.4 0.0092 15.8 0.3 4.7 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO35025.1 - 0.008 16.5 0.1 4.1 7.8 0.0 3.2 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KOO35025.1 - 0.086 12.7 0.9 7 6.6 0.0 3.2 3 0 0 3 3 3 0 EF hand Bac_rhamnosid6H PF17389.2 KOO35026.1 - 2.2e-61 208.0 0.0 3.2e-61 207.5 0.0 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 KOO35026.1 - 3.4e-19 69.3 0.0 5.4e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 KOO35026.1 - 1.8e-18 66.4 0.0 3.5e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Gal_Lectin PF02140.18 KOO35026.1 - 4.5e-05 23.8 0.0 0.0001 22.7 0.0 1.6 1 0 0 1 1 1 1 Galactose binding lectin domain Bac_rhamnosid_C PF17390.2 KOO35026.1 - 0.00023 20.9 0.1 0.26 11.1 0.0 2.5 2 0 0 2 2 2 2 Bacterial alpha-L-rhamnosidase C-terminal domain Diphthamide_syn PF01866.17 KOO35027.1 - 9.2e-60 202.6 0.0 4.1e-35 121.7 0.0 2.2 1 1 1 2 2 2 2 Putative diphthamide synthesis protein Thioesterase PF00975.20 KOO35028.1 - 3.8e-10 40.3 0.0 4.8e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 KOO35028.1 - 0.00051 20.7 0.0 0.00062 20.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO35028.1 - 0.059 12.6 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 KOO35028.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Pkinase PF00069.25 KOO35029.1 - 1.1e-53 182.3 0.0 1.4e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35029.1 - 1.2e-34 119.7 0.0 1.6e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO35029.1 - 1.7e-06 27.6 0.0 2.7e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Epimerase_2 PF02350.19 KOO35030.1 - 0.031 13.2 1.0 0.056 12.3 1.0 1.3 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Calpain_inhib PF00748.19 KOO35030.1 - 0.17 12.4 2.6 0.34 11.4 0.6 2.2 2 0 0 2 2 2 0 Calpain inhibitor RRP36 PF06102.12 KOO35030.1 - 0.41 10.6 8.0 0.8 9.7 8.0 1.4 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 Laps PF10169.9 KOO35030.1 - 4.2 8.0 7.4 0.65 10.6 2.5 2.0 1 1 1 2 2 2 0 Learning-associated protein DUF1295 PF06966.12 KOO35031.1 - 2.2e-34 119.0 2.8 6.2e-34 117.5 2.8 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 KOO35031.1 - 0.0033 17.4 0.1 0.008 16.2 0.1 1.7 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase HD_4 PF13328.6 KOO35032.1 - 6.4e-35 120.2 0.5 1.3e-34 119.3 0.5 1.5 1 0 0 1 1 1 1 HD domain HD PF01966.22 KOO35032.1 - 8.4e-07 29.2 0.0 3.3e-06 27.3 0.0 2.0 1 1 0 1 1 1 1 HD domain UreF PF01730.16 KOO35032.1 - 0.13 12.9 2.2 0.15 12.7 0.2 2.2 2 0 0 2 2 2 0 UreF DprA_WH PF17782.1 KOO35032.1 - 6.4 7.0 7.1 1.5 9.0 0.1 3.4 3 0 0 3 3 3 0 DprA winged helix domain DEAD PF00270.29 KOO35033.1 - 8e-08 32.3 0.0 1.2e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOO35033.1 - 3.3e-06 27.2 0.0 4.3e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 KOO35033.1 - 0.0041 16.0 0.1 0.0086 15.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Exo_endo_phos PF03372.23 KOO35034.1 - 1.1e-06 28.4 0.1 1.7e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2475 PF10629.9 KOO35035.1 - 0.011 16.0 11.6 0.22 11.7 0.2 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2475) Lebercilin PF15619.6 KOO35035.1 - 0.038 13.6 3.4 0.054 13.2 3.4 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Nuc_rec_co-act PF08815.10 KOO35036.1 - 0.057 13.3 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Nuclear receptor coactivator TrbC PF04956.13 KOO35036.1 - 0.7 10.2 4.2 0.51 10.6 0.1 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family Ras PF00071.22 KOO35038.1 - 5.1e-27 94.5 0.0 9.4e-27 93.6 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KOO35038.1 - 3.8e-12 46.5 0.0 9.7e-12 45.2 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase WW PF00397.26 KOO35038.1 - 2.9e-07 30.5 4.0 6.1e-07 29.4 4.0 1.6 1 0 0 1 1 1 1 WW domain Arf PF00025.21 KOO35038.1 - 0.00044 19.7 0.0 0.004 16.6 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family NACHT PF05729.12 KOO35038.1 - 0.037 13.9 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 KOO35038.1 - 0.11 12.8 0.0 0.55 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain PKD_channel PF08016.12 KOO35039.1 - 1e-19 70.5 8.5 1.2e-19 70.3 8.5 1.1 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 KOO35039.1 - 1.1e-09 38.0 10.3 1.3e-09 37.6 10.3 1.1 1 0 0 1 1 1 1 Ion transport protein ABC_trans_N PF14510.6 KOO35040.1 - 0.49 11.0 4.9 4.4 8.0 0.2 2.7 2 0 0 2 2 2 0 ABC-transporter N-terminal BCDHK_Adom3 PF10436.9 KOO35040.1 - 0.86 9.4 4.2 1.7 8.4 1.4 2.5 2 1 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase CIAPIN1 PF05093.13 KOO35040.1 - 1.3 9.6 4.3 3.2 8.3 1.8 2.7 2 1 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis TPR_10 PF13374.6 KOO35042.1 - 1.3e-68 225.1 29.4 7.8e-13 47.8 0.3 7.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_12 PF13424.6 KOO35042.1 - 1.9e-60 201.1 36.1 7e-17 61.5 2.0 5.1 2 1 4 6 6 6 6 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO35042.1 - 2.7e-25 89.5 9.4 5.9e-13 48.9 3.4 3.0 1 1 2 3 3 3 3 MalT-like TPR region TPR_8 PF13181.6 KOO35042.1 - 4.8e-24 82.5 3.2 0.0088 16.2 0.0 7.0 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 KOO35042.1 - 2e-23 81.2 12.3 0.0014 18.4 0.0 6.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 KOO35042.1 - 2.5e-20 70.9 18.3 0.038 14.1 0.2 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_4 PF07721.14 KOO35042.1 - 6.1e-20 69.7 22.9 0.0048 17.4 0.7 8.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 KOO35042.1 - 2e-15 55.6 23.6 0.038 14.0 0.2 6.9 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 KOO35042.1 - 1.2e-12 47.3 3.2 3.3 8.3 0.1 7.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO35042.1 - 7.4e-10 39.3 32.3 0.068 13.8 4.5 6.8 2 1 5 7 7 7 7 Tetratricopeptide repeat TPR_11 PF13414.6 KOO35042.1 - 8.5e-10 38.2 15.7 0.28 10.9 0.1 7.1 7 0 0 7 7 7 3 TPR repeat TPR_3 PF07720.12 KOO35042.1 - 3.2e-09 36.6 0.0 4.2 7.5 0.0 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO35042.1 - 3.9e-09 36.6 2.2 1.7 8.9 0.0 5.6 5 0 0 5 5 5 3 Osmosensory transporter coiled coil TPR_19 PF14559.6 KOO35042.1 - 6.2e-08 33.0 22.1 0.046 14.2 0.3 5.1 2 1 2 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOO35042.1 - 4.1e-07 30.3 28.6 4.8 8.3 0.2 7.4 7 0 0 7 7 7 1 Tetratricopeptide repeat FYRN PF05964.14 KOO35042.1 - 0.012 15.4 1.9 46 4.0 0.0 4.7 6 0 0 6 6 6 0 F/Y-rich N-terminus TPR_21 PF09976.9 KOO35042.1 - 0.024 14.4 13.5 6.1 6.5 0.0 5.3 2 2 2 5 5 5 0 Tetratricopeptide repeat-like domain MIT PF04212.18 KOO35042.1 - 0.026 14.6 0.3 78 3.5 0.0 3.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain RPN6_N PF18055.1 KOO35042.1 - 0.033 14.5 0.0 6.5 7.1 0.0 3.3 2 2 3 5 5 5 0 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_6 PF13174.6 KOO35042.1 - 6.7 7.6 17.2 2.1e+02 2.9 0.1 6.5 7 0 0 7 7 6 0 Tetratricopeptide repeat PCMT PF01135.19 KOO35043.1 - 0.00034 20.4 0.0 0.00042 20.1 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF4213 PF13938.6 KOO35043.1 - 0.013 15.7 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 Putative heavy-metal chelation MTS PF05175.14 KOO35043.1 - 0.066 12.8 0.0 0.087 12.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 KOO35043.1 - 0.081 13.6 0.0 0.14 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 KOO35043.1 - 0.12 12.2 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_6 PF13405.6 KOO35044.1 - 1.9e-08 33.5 0.1 0.0078 16.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO35044.1 - 3.4e-07 29.3 0.1 0.011 15.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO35044.1 - 3.2e-05 23.2 0.1 0.023 14.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO35044.1 - 0.0019 18.6 0.1 0.98 9.9 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair Tannase PF07519.11 KOO35044.1 - 0.032 13.2 0.1 0.049 12.5 0.1 1.2 1 0 0 1 1 1 0 Tannase and feruloyl esterase LRV_FeS PF05484.11 KOO35045.1 - 0.071 13.1 1.5 10 6.2 0.0 3.0 3 0 0 3 3 3 0 LRV protein FeS4 cluster Shikimate_DH PF01488.20 KOO35045.1 - 0.075 13.1 1.2 10 6.2 0.0 2.8 1 1 2 3 3 3 0 Shikimate / quinate 5-dehydrogenase Repressor_Mnt PF11423.8 KOO35045.1 - 2.6 7.9 9.2 27 4.7 0.4 3.5 3 0 0 3 3 3 0 Regulatory protein Mnt TGT_C1 PF14809.6 KOO35045.1 - 8.1 6.8 6.6 61 4.0 0.2 3.0 3 0 0 3 3 3 0 C1 domain of tRNA-guanine transglycosylase dimerisation LVIVD PF08309.11 KOO35047.1 - 1.7e-118 385.7 129.2 9e-12 44.1 3.8 14.2 14 0 0 14 14 14 14 LVIVD repeat PSCyt3 PF07627.11 KOO35047.1 - 1.4e-11 44.5 2.5 0.34 11.2 0.0 9.2 6 3 3 10 10 10 1 Protein of unknown function (DUF1588) SBP56 PF05694.11 KOO35047.1 - 1.2e-05 24.4 0.0 0.38 9.5 0.0 6.2 3 2 2 7 7 7 1 56kDa selenium binding protein (SBP56) Beta_propel PF09826.9 KOO35047.1 - 2.1e-05 23.6 3.9 25 3.5 0.0 7.9 7 2 0 9 9 9 0 Beta propeller domain Chitin_bind_4 PF00379.23 KOO35047.1 - 7.4e-05 23.2 40.7 33 5.1 0.0 13.1 13 1 1 14 14 14 0 Insect cuticle protein DUF4440 PF14534.6 KOO35047.1 - 0.1 13.0 2.3 41 4.7 0.0 5.2 5 1 0 5 5 5 0 Domain of unknown function (DUF4440) HCV_NS5a_1b PF08301.13 KOO35047.1 - 1.9 9.1 18.1 13 6.4 0.1 8.1 5 2 2 9 9 9 0 Hepatitis C virus non-structural 5a domain 1b DUF3060 PF11259.8 KOO35047.1 - 4.4 7.1 7.2 67 3.3 0.0 5.1 5 0 0 5 5 5 0 Protein of unknown function (DUF3060) Dynamin_N PF00350.23 KOO35048.1 - 1.7e-06 28.2 0.0 2.5e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Dynamin family U-box PF04564.15 KOO35048.1 - 0.00011 22.3 0.0 0.00019 21.5 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 KOO35048.1 - 0.0083 16.2 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein TniB PF05621.11 KOO35048.1 - 0.035 13.5 0.0 0.21 10.9 0.0 1.9 1 1 1 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 KOO35048.1 - 0.065 13.6 0.7 0.31 11.4 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.18 KOO35048.1 - 0.099 12.5 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF1455 PF07306.11 KOO35048.1 - 0.12 12.3 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1455) SNF2_N PF00176.23 KOO35050.1 - 1.2e-33 116.3 0.0 2.4e-27 95.6 0.1 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain DEAD PF00270.29 KOO35050.1 - 7.6e-09 35.6 0.0 1.8e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO35050.1 - 8.4e-09 35.8 0.0 1.7e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO35050.1 - 4.2e-08 33.4 0.0 5.4e-07 29.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 KOO35050.1 - 0.0086 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 KOO35050.1 - 0.049 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Serglycin PF04360.12 KOO35050.1 - 0.16 11.9 0.3 1 9.3 0.7 2.0 2 0 0 2 2 2 0 Serglycin Pkinase PF00069.25 KOO35052.1 - 2e-41 142.1 0.0 4.2e-27 95.2 0.0 2.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35052.1 - 6.8e-21 74.7 0.0 8.4e-12 44.9 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase FTA2 PF13095.6 KOO35052.1 - 0.036 13.7 0.0 8.2 6.0 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PKcGMP_CC PF16808.5 KOO35052.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Mito_carr PF00153.27 KOO35054.1 - 4.4e-40 135.5 0.4 2.6e-16 59.3 0.0 4.3 3 1 0 3 3 3 3 Mitochondrial carrier protein adh_short_C2 PF13561.6 KOO35055.1 - 1.9e-21 76.7 0.2 2.1e-21 76.6 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO35055.1 - 4.5e-18 65.4 0.0 5.7e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Cupin_8 PF13621.6 KOO35056.1 - 4.3e-13 49.6 0.0 4.5e-11 42.9 0.0 2.2 1 1 1 2 2 2 2 Cupin-like domain Cupin_4 PF08007.12 KOO35056.1 - 7.6e-05 22.3 0.1 0.00017 21.2 0.0 1.5 2 0 0 2 2 2 1 Cupin superfamily protein PP2C PF00481.21 KOO35057.1 - 2.8e-40 138.6 0.0 1.4e-31 110.1 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C WD40 PF00400.32 KOO35058.1 - 8.1e-67 219.5 18.3 2.2e-09 37.8 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO35058.1 - 2.9e-22 79.1 9.7 0.015 14.3 0.0 7.0 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO35058.1 - 6.8e-20 71.2 6.9 0.015 15.6 0.1 6.9 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO35058.1 - 2.4e-19 68.7 0.9 0.39 10.7 0.0 7.3 7 0 0 7 7 7 7 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOO35058.1 - 5.9e-11 41.4 0.1 0.1 10.9 0.0 5.1 1 1 5 6 6 6 6 WD repeat-containing and planar cell polarity effector protein Fritz BBS2_Mid PF14783.6 KOO35058.1 - 2.6e-09 37.1 1.5 2.9 8.0 0.0 6.6 1 1 6 7 7 7 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 KOO35058.1 - 6.9e-06 25.6 2.2 2.2 7.5 0.0 4.8 2 2 2 5 5 5 2 WD40-like domain Osteoregulin PF07175.11 KOO35058.1 - 2.6e-05 24.5 0.2 4.4 7.5 0.0 4.6 2 1 3 5 5 5 1 Osteoregulin WD40_3 PF15911.5 KOO35058.1 - 0.0012 18.8 0.7 73 3.5 0.0 6.0 7 0 0 7 7 7 0 WD domain, G-beta repeat CIDE-N PF02017.15 KOO35058.1 - 0.0075 16.3 0.0 34 4.6 0.0 5.2 3 2 3 7 7 7 0 CIDE-N domain TcfC PF16967.5 KOO35058.1 - 0.009 15.5 0.0 8.7 5.9 0.0 3.5 5 0 0 5 5 5 1 E-set like domain FAM165 PF14981.6 KOO35058.1 - 0.01 15.6 0.0 31 4.5 0.0 4.2 5 0 0 5 5 4 0 FAM165 family AsnC_trans_reg PF01037.21 KOO35058.1 - 0.053 13.5 0.3 82 3.3 0.0 4.6 6 0 0 6 6 6 0 Lrp/AsnC ligand binding domain POT1PC PF16686.5 KOO35058.1 - 0.089 12.7 3.5 16 5.4 0.0 4.6 2 1 4 6 6 6 0 ssDNA-binding domain of telomere protection protein Peptidase_S9_N PF02897.15 KOO35058.1 - 0.09 11.6 4.1 0.3 9.9 0.5 3.1 1 1 3 4 4 4 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Spc110_C PF18520.1 KOO35058.1 - 0.17 11.5 7.8 17 5.1 0.1 5.1 6 0 0 6 6 6 0 Spindle pole body component 110 C-terminal domain Proteasome_A_N PF10584.9 KOO35058.1 - 0.46 10.2 18.8 17 5.2 0.1 7.3 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature Dfp1_Him1_M PF08630.10 KOO35058.1 - 1.2 9.4 11.6 8.2 6.7 0.2 5.1 6 1 0 6 6 6 0 Dfp1/Him1, central region Clathrin PF00637.20 KOO35059.1 - 0.00071 19.5 0.0 0.0044 16.9 0.0 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 KOO35059.1 - 0.026 14.4 0.9 0.071 13.0 0.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOO35059.1 - 0.044 14.1 0.8 0.12 12.7 0.8 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KOO35059.1 - 0.075 12.8 0.1 0.24 11.2 0.1 1.9 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 KOO35059.1 - 0.16 11.8 0.2 0.43 10.5 0.2 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOO35059.1 - 0.4 11.1 2.3 0.81 10.1 1.2 2.2 2 0 0 2 2 2 0 Ring finger domain BRCT_2 PF16589.5 KOO35060.1 - 0.00052 20.4 0.0 0.00081 19.8 0.0 1.3 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 KOO35060.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 twin BRCT domain HSP70 PF00012.20 KOO35061.1 - 2.3e-136 455.4 5.4 2.3e-136 455.4 5.4 2.2 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 KOO35061.1 - 7e-11 41.5 0.6 7e-11 41.5 0.6 1.8 2 0 0 2 2 2 1 MreB/Mbl protein PSII_Pbs27 PF13326.6 KOO35061.1 - 3.6 7.9 6.8 0.36 11.1 0.6 2.5 3 1 0 3 3 3 0 Photosystem II Pbs27 HECT PF00632.25 KOO35062.1 - 3.9e-25 89.0 0.0 4.6e-25 88.7 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) NOD PF06816.13 KOO35062.1 - 0.052 13.2 0.2 0.11 12.2 0.2 1.5 1 0 0 1 1 1 0 NOTCH protein PAC2 PF09754.9 KOO35062.1 - 0.091 12.8 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 PAC2 family DUF4880 PF16220.5 KOO35063.1 - 0.064 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4880) Ank PF00023.30 KOO35064.1 - 0.00066 20.0 0.1 0.0016 18.8 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 KOO35064.1 - 0.014 15.9 0.0 0.034 14.7 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeat Ank_4 PF13637.6 KOO35064.1 - 0.021 15.4 0.0 0.53 10.9 0.0 2.3 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Lipoprotein_X PF03305.13 KOO35064.1 - 0.19 11.5 0.0 0.27 11.0 0.0 1.1 1 0 0 1 1 1 0 Mycoplasma MG185/MG260 protein DUF3858 PF12970.7 KOO35068.1 - 0.13 12.3 0.1 0.26 11.3 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3858) AID PF18767.1 KOO35069.1 - 0.61 10.1 3.8 78 3.4 0.0 4.8 6 0 0 6 6 6 0 Activation induced deaminase VCBS PF13517.6 KOO35070.1 - 2.7e-140 457.0 158.7 1.6e-13 51.0 4.0 14.2 2 2 12 14 14 14 14 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO35070.1 - 1.6e-68 226.4 152.7 2.1e-05 24.5 2.1 15.7 15 0 0 15 15 15 15 FG-GAP repeat Dockerin_1 PF00404.18 KOO35070.1 - 1.8e-21 76.1 34.6 1.3 9.3 0.0 15.0 15 0 0 15 15 15 10 Dockerin type I domain DUF1629 PF07791.11 KOO35070.1 - 0.0003 20.9 0.0 2.2e+02 2.0 0.0 7.7 10 0 0 10 10 10 0 Protein of unknown function (DUF1629) TM_PBP2_N PF16296.5 KOO35070.1 - 0.0021 18.2 0.0 22 5.2 0.0 7.0 10 0 0 10 10 10 1 N-terminal of TM subunit in PBP-dependent ABC transporters TcdB_toxin_midN PF12256.8 KOO35070.1 - 0.027 13.9 69.3 4.6 6.6 0.2 14.8 4 2 11 15 15 15 0 Insecticide toxin TcdB middle/N-terminal region EF-hand_1 PF00036.32 KOO35070.1 - 1.4 8.7 66.5 17 5.3 0.2 14.8 15 0 0 15 15 15 0 EF hand EF-hand_13 PF17958.1 KOO35071.1 - 2e-11 43.5 0.0 5.1e-11 42.2 0.0 1.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO35071.1 - 2.5e-11 43.9 0.0 6.8e-10 39.3 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO35071.1 - 6.8e-06 25.6 1.4 0.0082 16.0 0.1 3.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 KOO35071.1 - 2.1e-05 23.7 1.2 0.052 13.1 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO35071.1 - 0.0046 16.4 5.3 0.007 15.8 0.0 2.7 3 0 0 3 3 3 1 EF hand SPARC_Ca_bdg PF10591.9 KOO35071.1 - 0.1 12.9 0.1 9.2 6.6 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Pentapeptide PF00805.22 KOO35072.1 - 1.4e-14 53.4 17.1 1.8e-09 37.0 1.6 3.2 1 1 2 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 KOO35072.1 - 1.5e-09 37.9 1.0 7.2e-09 35.7 1.0 1.9 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 KOO35072.1 - 1.2e-07 31.7 1.2 0.0012 18.9 0.8 2.6 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Herpes_capsid PF06112.11 KOO35072.1 - 0.079 13.0 1.2 0.12 12.4 1.2 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Pkinase PF00069.25 KOO35073.1 - 1.6e-42 145.7 0.0 2.1e-42 145.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35073.1 - 8.6e-22 77.7 0.0 1.1e-21 77.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO35073.1 - 2.6e-07 30.2 0.0 3.6e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO35073.1 - 9e-05 22.5 0.9 0.00025 21.0 0.7 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family YukC PF10140.9 KOO35073.1 - 0.0044 15.9 0.0 0.0055 15.6 0.0 1.1 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Haspin_kinase PF12330.8 KOO35073.1 - 0.0085 15.1 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOO35073.1 - 0.013 14.9 0.1 0.018 14.4 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VPS9 PF02204.18 KOO35074.1 - 6.2e-18 64.9 0.0 4.6e-14 52.5 0.0 2.2 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain DUF3678 PF12435.8 KOO35074.1 - 0.029 13.7 0.3 0.077 12.4 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) TT_ORF2 PF02957.15 KOO35074.1 - 5.4 7.9 7.9 0.72 10.8 2.6 2.3 2 1 0 2 2 2 0 TT viral ORF2 PPC PF04151.15 KOO35077.1 - 0.032 15.3 0.0 0.099 13.8 0.0 1.9 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain DUF4419 PF14388.6 KOO35078.1 - 4.8e-23 82.0 0.0 5.6e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) SnoaL_2 PF12680.7 KOO35078.1 - 0.13 12.9 5.5 0.51 11.0 0.5 2.6 2 0 0 2 2 2 0 SnoaL-like domain Glyco_transf_8 PF01501.20 KOO35079.1 - 9.6e-09 35.2 1.2 1.6e-07 31.2 1.2 2.6 1 1 0 1 1 1 1 Glycosyl transferase family 8 Vitellogenin_N PF01347.22 KOO35080.1 - 0.15 10.5 0.0 0.19 10.1 0.0 1.1 1 0 0 1 1 1 0 Lipoprotein amino terminal region GTP_CH_N PF12471.8 KOO35083.1 - 1.6e-137 455.4 0.0 6.3e-75 251.2 0.0 2.2 2 0 0 2 2 2 2 GTP cyclohydrolase N terminal DUF591 PF04569.14 KOO35086.1 - 0.15 12.1 8.2 0.33 11.0 3.6 2.8 2 1 0 2 2 2 0 Protein of unknown function Glyco_tranf_2_3 PF13641.6 KOO35087.1 - 2e-23 83.5 0.0 2.9e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 KOO35087.1 - 1.9e-15 57.1 0.0 3.8e-15 56.1 0.0 1.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 KOO35087.1 - 8.5e-14 51.9 0.0 1.6e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 KOO35087.1 - 1.8e-09 37.3 0.0 3e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 DUF5582 PF17819.1 KOO35088.1 - 0.0001 22.8 0.0 0.00015 22.3 0.0 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5582) PhoR PF11808.8 KOO35089.1 - 0.058 13.8 8.4 0.45 11.0 1.9 2.5 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR DctQ PF04290.12 KOO35089.1 - 0.075 12.9 5.6 0.18 11.7 0.1 2.4 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component UIM PF02809.20 KOO35090.1 - 1.3e-05 24.7 29.4 0.0026 17.6 2.5 5.7 4 0 0 4 4 4 3 Ubiquitin interaction motif RNase_Zc3h12a PF11977.8 KOO35090.1 - 0.003 17.4 0.0 0.18 11.6 0.0 2.4 2 0 0 2 2 2 2 Zc3h12a-like Ribonuclease NYN domain NAD_Gly3P_dh_C PF07479.14 KOO35091.1 - 2.6e-48 163.9 1.2 4.6e-48 163.1 0.3 1.8 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 KOO35091.1 - 1.5e-39 135.5 0.0 4.8e-39 133.9 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Semialdhyde_dh PF01118.24 KOO35091.1 - 0.00044 20.7 0.0 0.00094 19.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KOO35091.1 - 0.0025 18.3 0.1 0.18 12.4 0.1 2.5 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Aha1_N PF09229.11 KOO35096.1 - 1.9e-12 47.5 0.0 3.2e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal DUF3562 PF12085.8 KOO35096.1 - 0.033 13.8 0.5 0.56 9.9 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3562) FTA4 PF13093.6 KOO35096.1 - 0.1 12.5 0.3 0.13 12.1 0.3 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 TipAS PF07739.13 KOO35096.1 - 0.35 11.4 2.3 0.58 10.7 0.9 1.9 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain SdpI PF13630.6 KOO35097.1 - 5 7.3 6.8 7.3 6.8 0.1 3.7 4 1 0 4 4 4 0 SdpI/YhfL protein family EF-hand_6 PF13405.6 KOO35099.1 - 2.4e-24 83.1 8.1 3.7e-05 23.3 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO35099.1 - 1.1e-22 77.8 13.9 1.2e-05 24.5 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO35099.1 - 9.9e-20 70.8 9.5 1.2e-09 38.5 0.8 2.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO35099.1 - 8.9e-14 51.1 12.2 9.9e-06 25.3 0.1 4.5 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO35099.1 - 4.7e-11 41.7 18.6 0.0042 16.5 0.7 4.5 4 0 0 4 4 4 4 EF hand Caleosin PF05042.13 KOO35099.1 - 0.0036 17.3 2.6 1.9 8.4 0.1 3.9 2 2 2 4 4 4 1 Caleosin related protein UPF0223 PF05256.12 KOO35099.1 - 0.0069 16.7 0.0 0.12 12.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0223) RST PF12174.8 KOO35099.1 - 0.016 15.1 0.1 0.058 13.3 0.0 1.9 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Armet PF10208.9 KOO35099.1 - 0.045 13.7 0.0 9.7 6.1 0.0 2.7 2 1 1 3 3 3 0 Degradation arginine-rich protein for mis-folding EF-hand_9 PF14658.6 KOO35099.1 - 0.1 12.9 0.0 26 5.2 0.0 3.3 4 0 0 4 4 3 0 EF-hand domain EF-hand_10 PF14788.6 KOO35099.1 - 0.1 12.5 5.8 32 4.5 0.1 4.0 3 1 1 4 4 4 0 EF hand SAM_Exu PF18609.1 KOO35099.1 - 3.8 7.7 5.5 13 6.0 0.4 3.1 2 1 1 3 3 3 0 Exuperantia SAM-like domain Ephrin_rec_like PF07699.13 KOO35101.1 - 7.6e-11 41.6 19.2 1.7e-09 37.3 6.3 3.6 2 1 1 3 3 3 2 Putative ephrin-receptor like RED_N PF07808.13 KOO35102.1 - 5.6e-31 107.9 0.6 1.7e-30 106.4 0.5 1.9 1 1 0 1 1 1 1 RED-like protein N-terminal region Pkinase PF00069.25 KOO35109.1 - 3.3e-46 157.8 0.0 4e-46 157.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35109.1 - 7.2e-43 146.7 0.0 1.3e-42 145.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO35109.1 - 2.1e-06 26.8 0.0 3.1e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO35109.1 - 0.0022 17.4 0.0 0.0029 16.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO35109.1 - 0.068 13.1 0.1 0.13 12.2 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO35109.1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Zeta_toxin PF06414.12 KOO35110.1 - 2.4e-06 27.0 0.0 3.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin PRK PF00485.18 KOO35110.1 - 0.00032 20.5 0.0 0.00047 19.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family MeaB PF03308.16 KOO35110.1 - 0.0016 17.5 0.0 0.0025 16.9 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 KOO35110.1 - 0.0023 17.2 0.2 0.018 14.2 0.0 2.0 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 KOO35110.1 - 0.0079 16.6 0.0 0.019 15.3 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain YHS PF04945.13 KOO35110.1 - 0.011 15.8 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 YHS domain AAA_18 PF13238.6 KOO35110.1 - 0.012 16.2 0.1 0.04 14.5 0.0 2.0 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 KOO35110.1 - 0.046 13.9 0.1 0.12 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KOO35110.1 - 0.078 13.2 2.1 0.1 12.8 0.3 2.3 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KOO35110.1 - 0.082 13.3 0.3 0.16 12.4 0.3 1.4 1 0 0 1 1 1 0 AAA domain DUF3646 PF12362.8 KOO35110.1 - 0.11 12.8 1.4 0.65 10.3 0.0 2.5 2 1 0 2 2 2 0 DNA polymerase III gamma and tau subunits C terminal ABC_tran PF00005.27 KOO35110.1 - 0.13 12.8 0.0 0.22 12.1 0.0 1.3 1 0 0 1 1 1 0 ABC transporter KAP_NTPase PF07693.14 KOO35110.1 - 0.15 11.2 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain AAA PF00004.29 KOO35110.1 - 0.16 12.4 0.0 0.27 11.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CoaE PF01121.20 KOO35110.1 - 0.17 11.6 0.2 0.31 10.7 0.2 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_29 PF13555.6 KOO35110.1 - 0.17 11.6 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rubella_E2 PF05749.11 KOO35111.1 - 0.0052 16.3 0.0 0.0091 15.5 0.0 1.3 1 0 0 1 1 1 1 Rubella membrane glycoprotein E2 Scramblase PF03803.15 KOO35113.1 - 1.5e-22 80.0 0.0 6.7e-22 77.9 0.0 1.8 1 1 0 1 1 1 1 Scramblase AAA PF00004.29 KOO35114.1 - 0.003 18.0 0.0 0.0042 17.5 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 KOO35114.1 - 0.048 13.1 0.0 0.06 12.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein DUF4639 PF15479.6 KOO35116.1 - 1.1e-08 34.6 1.2 1.8e-08 33.8 1.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4639) LRR_6 PF13516.6 KOO35117.1 - 1.7e-11 43.2 0.8 0.00011 21.9 0.1 3.7 3 0 0 3 3 3 3 Leucine Rich repeat DUF667 PF05018.13 KOO35117.1 - 2.7e-10 40.3 0.0 4e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF667) RCDG1 PF15725.5 KOO35117.1 - 0.052 14.0 0.4 0.2 12.1 0.4 2.1 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein Kelch_1 PF01344.25 KOO35119.1 - 2.7e-102 334.2 0.5 5.4e-18 64.3 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KOO35119.1 - 1.1e-58 193.8 0.0 4.2e-10 39.5 0.0 6.3 1 1 5 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KOO35119.1 - 1.7e-50 167.1 0.0 1.6e-08 34.2 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KOO35119.1 - 4.3e-44 148.0 1.8 6.7e-08 32.6 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO35119.1 - 1.1e-32 111.7 0.0 0.00016 21.6 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO35119.1 - 1.9e-23 81.9 2.7 0.0054 16.7 0.0 6.7 7 0 0 7 7 7 6 Kelch motif BACK PF07707.15 KOO35119.1 - 4.6e-18 65.2 0.0 9e-18 64.3 0.0 1.5 2 0 0 2 2 1 1 BTB And C-terminal Kelch BTB PF00651.31 KOO35119.1 - 2.6e-15 56.6 0.0 4.1e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF1668 PF07893.13 KOO35119.1 - 4.3e-07 29.6 0.3 1.4 8.2 0.0 5.1 1 1 4 5 5 5 1 Protein of unknown function (DUF1668) DUF4318 PF14201.6 KOO35119.1 - 2e-05 25.0 0.0 7.5 7.1 0.0 5.1 5 0 0 5 5 5 1 Domain of unknown function (DUF4318) VLPT PF07122.11 KOO35119.1 - 0.0056 16.4 0.2 18 5.2 0.0 4.3 5 0 0 5 5 5 0 Variable length PCR target protein (VLPT) DciA PF05258.12 KOO35119.1 - 0.0073 16.7 0.0 3.9 7.9 0.0 4.3 5 0 0 5 5 5 1 Dna[CI] antecedent, DciA HCMV_UL124 PF17609.2 KOO35119.1 - 0.54 10.5 6.8 48 4.2 0.0 4.7 3 1 3 6 6 6 0 Family of unknown function Filamin PF00630.19 KOO35120.1 - 1.9e-23 83.2 0.1 5e-15 56.2 0.0 2.5 2 0 0 2 2 2 2 Filamin/ABP280 repeat Kelch_4 PF13418.6 KOO35120.1 - 1.8e-17 63.0 0.3 1.5e-05 24.9 0.0 4.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KOO35120.1 - 3.4e-14 52.7 0.9 3.9e-06 27.0 0.0 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO35120.1 - 4.8e-12 45.6 0.1 0.026 14.5 0.0 4.8 4 0 0 4 4 4 3 Kelch motif Laminin_G_3 PF13385.6 KOO35120.1 - 2.7e-11 43.8 0.2 4e-09 36.8 0.0 3.5 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Kelch_6 PF13964.6 KOO35120.1 - 1.9e-08 34.3 1.5 0.0093 16.2 0.0 5.0 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 KOO35120.1 - 1e-07 31.4 0.7 0.23 11.0 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 KOO35120.1 - 0.0017 18.2 0.0 2.6 8.2 0.0 3.2 2 0 0 2 2 2 2 Kelch motif Invasin_D3 PF09134.10 KOO35120.1 - 0.0039 17.5 0.1 2.9 8.2 0.4 2.6 2 0 0 2 2 2 2 Invasin, domain 3 Trypsin_2 PF13365.6 KOO35121.1 - 2.4e-22 80.4 2.2 3.8e-22 79.8 2.2 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 KOO35121.1 - 2.5e-12 46.4 1.4 2.4e-11 43.3 0.0 2.5 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO35121.1 - 1e-08 35.3 0.0 3.4e-08 33.7 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KOO35121.1 - 1.3e-07 31.8 0.0 6.3e-07 29.7 0.0 2.1 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.26 KOO35121.1 - 9.9e-07 28.8 0.1 1.4e-06 28.3 0.1 1.2 1 0 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.6 KOO35121.1 - 0.005 16.8 0.2 0.019 14.9 0.0 2.0 2 1 0 2 2 2 1 Tricorn protease PDZ domain GTP_EFTU_D4 PF14578.6 KOO35121.1 - 0.0083 16.0 0.9 0.93 9.4 0.0 2.9 2 1 0 2 2 2 1 Elongation factor Tu domain 4 Peptidase_S29 PF02907.15 KOO35121.1 - 0.032 14.0 0.1 0.057 13.2 0.1 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Peptidase_S7 PF00949.21 KOO35121.1 - 0.11 12.3 0.5 0.2 11.5 0.3 1.5 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.9 KOO35121.1 - 0.14 10.7 1.0 0.21 10.2 0.6 1.4 2 0 0 2 2 2 0 Peptidase S46 Scramblase PF03803.15 KOO35122.1 - 5.8e-12 45.4 0.0 3e-08 33.2 0.0 2.5 2 1 0 2 2 2 2 Scramblase Radical_SAM PF04055.21 KOO35124.1 - 0.0011 19.3 0.0 0.0018 18.7 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily MscS_porin PF12795.7 KOO35124.1 - 0.097 12.2 0.3 0.15 11.6 0.3 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Peptidase_M17_N PF02789.17 KOO35124.1 - 0.097 12.5 0.5 1.9 8.4 0.0 2.3 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain RasGAP_C PF03836.15 KOO35126.1 - 1e-05 25.7 4.2 1e-05 25.7 4.2 3.3 1 1 1 2 2 2 1 RasGAP C-terminus LytR_C PF13399.6 KOO35126.1 - 0.18 12.8 0.4 20 6.2 0.1 2.7 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator VitD-bind_III PF09164.10 KOO35126.1 - 0.82 9.7 3.8 8.6 6.4 0.0 3.6 4 0 0 4 4 4 0 Vitamin D binding protein, domain III BTB PF00651.31 KOO35127.1 - 1.1e-15 57.8 0.0 2.1e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain C12orf66_like PF09404.10 KOO35127.1 - 0.031 13.1 0.0 0.044 12.6 0.0 1.1 1 0 0 1 1 1 0 KICSTOR complex C12orf66 like DHHA2 PF02833.14 KOO35128.1 - 2.3e-09 37.6 0.0 5.9e-09 36.2 0.0 1.7 2 1 0 2 2 2 1 DHHA2 domain ASH PF15780.5 KOO35129.1 - 8.4e-30 102.9 0.0 0.001 19.2 0.1 13.1 12 1 2 14 14 14 8 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin AAA_6 PF12774.7 KOO35129.1 - 5.8e-24 84.6 0.8 8.6e-24 84.1 0.8 1.2 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region PapD-like PF14874.6 KOO35129.1 - 1.1e-12 48.0 0.3 0.05 13.8 0.0 8.2 9 1 1 10 10 10 2 Flagellar-associated PapD-like DUF1573 PF07610.11 KOO35129.1 - 5.2e-07 29.6 0.0 19 5.3 0.0 7.7 10 0 0 10 10 10 2 Protein of unknown function (DUF1573) MYCBPAP PF14646.6 KOO35129.1 - 0.0029 16.6 0.0 12 4.7 0.0 4.9 6 0 0 6 6 6 1 MYCBP-associated protein family XG_FTase PF03254.13 KOO35130.1 - 3.6e-05 22.6 0.0 5.8e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Xyloglucan fucosyltransferase Thioredoxin_8 PF13905.6 KOO35132.1 - 8.6e-26 90.1 0.0 1.8e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 KOO35132.1 - 1.7e-07 31.2 0.0 3.6e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOO35132.1 - 1.1e-06 28.5 0.0 2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin PF00085.20 KOO35132.1 - 1.4e-05 25.0 0.0 0.00011 22.1 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin AAA PF00004.29 KOO35132.1 - 0.00018 22.0 0.0 0.00057 20.3 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Thioredoxin_2 PF13098.6 KOO35132.1 - 0.0025 18.2 0.0 0.0053 17.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain AAA_lid_6 PF17866.1 KOO35132.1 - 0.013 15.7 0.1 0.033 14.4 0.1 1.8 1 0 0 1 1 1 0 AAA lid domain DUF883 PF05957.13 KOO35132.1 - 0.023 15.3 0.4 0.069 13.8 0.4 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF1840 PF08895.11 KOO35132.1 - 0.088 13.1 0.0 5.8 7.3 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Flavodoxin_1 PF00258.25 KOO35133.1 - 5.2e-15 55.9 0.0 1e-13 51.7 0.0 2.3 1 1 0 1 1 1 1 Flavodoxin Ank_5 PF13857.6 KOO35133.1 - 1.1e-09 38.4 8.5 0.00078 19.7 0.8 3.8 2 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO35133.1 - 2.1e-09 37.7 8.0 5.1e-05 23.7 0.2 3.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO35133.1 - 6.2e-09 36.3 12.3 0.00012 22.6 1.7 4.0 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO35133.1 - 0.0002 21.6 9.7 2 9.3 0.1 5.8 5 1 2 7 7 7 2 Ankyrin repeat DUF4407 PF14362.6 KOO35134.1 - 0.049 13.0 6.6 0.052 12.9 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1690 PF07956.11 KOO35134.1 - 0.1 13.0 6.3 0.12 12.8 6.3 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF3987 PF13148.6 KOO35134.1 - 0.11 11.5 10.4 0.13 11.3 10.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF5631 PF18645.1 KOO35134.1 - 0.19 12.1 4.6 0.35 11.3 4.6 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5631) Spc7 PF08317.11 KOO35134.1 - 0.2 10.5 4.3 0.2 10.5 4.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Csm1_N PF18504.1 KOO35134.1 - 0.25 11.7 5.4 0.16 12.3 1.6 2.0 1 1 1 2 2 2 0 Csm1 N-terminal domain SlyX PF04102.12 KOO35134.1 - 0.34 11.6 3.5 0.29 11.8 1.3 1.8 1 1 1 2 2 2 0 SlyX Uso1_p115_C PF04871.13 KOO35134.1 - 0.92 9.9 12.2 1.1 9.7 12.2 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF3235 PF11574.8 KOO35134.1 - 3.4 8.6 11.3 6 7.8 11.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) RR_TM4-6 PF06459.12 KOO35134.1 - 4.9 6.9 8.8 5.1 6.8 8.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3138 PF11336.8 KOO35134.1 - 5.9 5.4 10.2 6.5 5.2 10.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) GD_AH_C PF04295.13 KOO35135.1 - 1.1e-104 350.4 0.0 2.1e-91 306.7 0.0 4.3 3 1 0 3 3 3 2 D-galactarate dehydratase / Altronate hydrolase, C terminus NIF PF03031.18 KOO35135.1 - 1.4e-34 119.1 0.0 2.1e-34 118.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SAF PF08666.12 KOO35135.1 - 1.4e-08 35.2 0.0 4.1e-08 33.7 0.0 1.9 1 0 0 1 1 1 1 SAF domain PKD_channel PF08016.12 KOO35137.1 - 3.5e-45 154.5 20.1 7.7e-37 127.0 21.8 2.3 2 0 0 2 2 2 2 Polycystin cation channel Ion_trans PF00520.31 KOO35137.1 - 4.6e-09 35.9 26.1 4.6e-09 35.9 26.1 1.7 2 0 0 2 2 2 1 Ion transport protein ECH_2 PF16113.5 KOO35137.1 - 0.69 9.3 3.3 1.4 8.3 3.3 1.4 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase TMEM171 PF15471.6 KOO35137.1 - 0.7 8.8 2.4 0.85 8.5 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein family 171 Atg14 PF10186.9 KOO35137.1 - 8.4 5.4 13.1 2.1 7.4 9.3 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 GLE1 PF07817.13 KOO35138.1 - 0.0063 15.7 2.2 0.0078 15.4 2.2 1.1 1 0 0 1 1 1 1 GLE1-like protein 3H PF02829.14 KOO35138.1 - 0.046 14.0 3.3 0.11 12.8 2.2 1.9 1 1 1 2 2 2 0 3H domain Muted PF14942.6 KOO35138.1 - 0.083 13.2 5.3 0.13 12.6 5.3 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF1497 PF07384.11 KOO35138.1 - 0.096 13.1 1.6 0.25 11.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1497) PVL_ORF50 PF07768.11 KOO35138.1 - 0.17 12.2 1.3 0.61 10.4 0.1 2.3 1 1 2 3 3 3 0 PVL ORF-50-like family FAM76 PF16046.5 KOO35138.1 - 0.2 11.0 6.1 0.26 10.6 5.0 1.5 1 1 0 1 1 1 0 FAM76 protein LOH1CR12 PF10158.9 KOO35138.1 - 0.85 9.6 5.6 2.1 8.4 4.4 2.0 1 1 1 2 2 2 0 Tumour suppressor protein Ribosomal_L37 PF08561.10 KOO35138.1 - 0.86 10.1 5.0 1.9 9.1 4.7 1.7 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L37 Mobilization_B PF17511.2 KOO35138.1 - 1.9 8.8 6.7 1 9.7 4.3 1.8 1 1 1 2 2 2 0 Mobilization protein B EF-hand_6 PF13405.6 KOO35140.1 - 1.7e-22 77.4 2.7 0.0001 21.9 0.0 5.9 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.6 KOO35140.1 - 3.2e-21 75.5 0.6 3.8e-07 30.5 0.1 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 KOO35140.1 - 5.5e-21 72.5 0.3 0.0031 16.9 0.0 5.9 6 0 0 6 6 6 5 EF hand EF-hand_5 PF13202.6 KOO35140.1 - 3.1e-15 54.9 0.3 0.00092 18.6 0.0 6.3 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KOO35140.1 - 7.9e-15 54.5 1.1 0.00011 22.0 0.0 5.2 4 1 1 5 5 5 5 EF-hand domain pair Ank_5 PF13857.6 KOO35140.1 - 0.011 16.0 0.0 0.034 14.5 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DUF4712 PF15830.5 KOO35140.1 - 0.11 12.2 1.7 0.24 11.1 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4712) Ank_4 PF13637.6 KOO35140.1 - 0.14 12.8 0.0 0.44 11.2 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Peptidase_C1 PF00112.23 KOO35141.1 - 1.6e-51 175.5 0.0 2.4e-51 174.9 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Ank_2 PF12796.7 KOO35141.1 - 2.2e-17 63.4 8.8 2.6e-09 37.5 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) AMP-binding PF00501.28 KOO35141.1 - 4.4e-13 48.6 0.3 1.1e-12 47.3 0.3 1.6 1 1 0 1 1 1 1 AMP-binding enzyme Ank_5 PF13857.6 KOO35141.1 - 8.4e-13 48.3 2.1 0.00018 21.7 0.3 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO35141.1 - 1.7e-12 47.5 2.4 1.2e-05 25.8 0.2 3.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35141.1 - 5e-09 35.7 2.6 0.18 12.4 0.0 4.9 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOO35141.1 - 2e-08 34.3 4.5 0.53 10.8 0.2 4.8 4 0 0 4 4 4 3 Ankyrin repeat Peptidase_C1_2 PF03051.15 KOO35141.1 - 3.5e-05 22.8 0.3 0.021 13.6 0.1 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.12 KOO35141.1 - 0.0012 19.3 0.1 0.0019 18.6 0.1 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) AMP-binding_C PF13193.6 KOO35141.1 - 0.0061 17.5 0.0 0.015 16.3 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PP-binding PF00550.25 KOO35141.1 - 0.023 15.1 0.0 0.058 13.8 0.0 1.7 1 0 0 1 1 1 0 Phosphopantetheine attachment site Bestrophin PF01062.21 KOO35142.1 - 1.4e-27 96.9 1.5 1.9e-27 96.5 1.5 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Acyl-CoA_dh_M PF02770.19 KOO35143.1 - 2.6e-08 34.0 0.1 4.7e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain CPSase_L_D2 PF02786.17 KOO35144.1 - 1.2e-15 57.6 0.1 3.2e-15 56.2 0.0 1.7 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 KOO35144.1 - 7.6e-14 51.7 0.0 2.1e-13 50.3 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HrpB1_HrpK PF09613.10 KOO35144.1 - 0.096 12.3 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) Pkinase PF00069.25 KOO35145.1 - 5.3e-22 78.5 0.1 1.2e-21 77.3 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain PARP PF00644.20 KOO35145.1 - 3e-15 56.3 0.0 9.1e-15 54.8 0.0 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase_Tyr PF07714.17 KOO35145.1 - 1.4e-11 44.2 0.2 3.2e-11 43.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PDZ_2 PF13180.6 KOO35146.1 - 0.0056 17.0 0.0 0.017 15.5 0.0 1.8 2 0 0 2 2 2 1 PDZ domain GRASP55_65 PF04495.14 KOO35146.1 - 0.016 15.5 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain PDZ PF00595.24 KOO35146.1 - 0.017 15.5 0.0 0.034 14.5 0.0 1.4 1 0 0 1 1 1 0 PDZ domain PDZ_6 PF17820.1 KOO35146.1 - 0.021 14.6 0.2 0.29 11.0 0.2 2.3 2 0 0 2 2 2 0 PDZ domain Lipocalin PF00061.23 KOO35146.1 - 0.14 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family SHIPPO-rpt PF07004.12 KOO35147.1 - 0.026 15.4 9.1 0.62 11.1 0.1 4.5 4 1 0 4 4 4 0 Sperm-tail PG-rich repeat DUF1104 PF06518.11 KOO35148.1 - 0.32 11.4 8.5 1.9 8.9 0.1 3.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1104) Ank_2 PF12796.7 KOO35150.1 - 1.3e-80 266.1 36.3 1.6e-18 67.0 0.4 6.7 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.30 KOO35150.1 - 8.9e-46 152.4 23.3 6.9e-05 23.1 0.1 12.8 11 1 1 12 12 12 10 Ankyrin repeat Ank_4 PF13637.6 KOO35150.1 - 1.4e-40 137.1 12.2 1e-06 29.2 0.0 7.9 5 1 2 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO35150.1 - 1e-37 127.7 21.2 5.9e-06 26.5 0.1 9.8 4 3 5 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35150.1 - 5.3e-36 118.5 15.5 0.0018 18.6 0.0 12.9 13 0 0 13 13 13 8 Ankyrin repeat NACHT PF05729.12 KOO35150.1 - 5.2e-05 23.2 0.0 0.00015 21.7 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 KOO35150.1 - 0.00039 20.1 1.2 0.0017 18.0 0.5 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO35150.1 - 0.018 15.5 0.3 0.018 15.5 0.3 3.3 3 1 0 3 3 3 0 AAA ATPase domain Transketolase_N PF00456.21 KOO35151.1 - 2.9e-108 361.8 0.5 4.2e-108 361.3 0.5 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 KOO35151.1 - 5.1e-41 140.3 0.1 1.1e-40 139.2 0.1 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 KOO35151.1 - 3.1e-08 33.2 0.1 8.8e-06 25.1 0.0 2.6 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 KOO35151.1 - 4.8e-07 29.0 0.2 8.9e-07 28.1 0.2 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_C PF02780.20 KOO35151.1 - 7.9e-06 25.8 0.3 5e-05 23.2 0.0 2.4 2 1 0 2 2 2 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 KOO35151.1 - 1.6e-05 24.7 1.7 0.0002 21.2 1.4 2.8 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF3939 PF13075.6 KOO35151.1 - 0.23 11.5 0.0 0.49 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) Ribosomal_L27A PF00828.19 KOO35152.1 - 0.00013 22.7 3.9 0.00021 21.9 3.5 1.6 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Cauli_VI PF01693.16 KOO35153.1 - 1.4e-12 47.7 1.4 2.3e-12 47.0 1.4 1.4 1 0 0 1 1 1 1 Caulimovirus viroplasmin RNase_H PF00075.24 KOO35153.1 - 1.7e-06 28.3 0.4 1.8e-05 25.0 0.4 2.2 1 1 0 1 1 1 1 RNase H CobW_C PF07683.14 KOO35154.1 - 4.9e-07 29.6 0.1 1.3e-06 28.3 0.1 1.7 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain DUF4091 PF13320.6 KOO35154.1 - 0.028 14.6 0.0 0.059 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4091) SAP18 PF06487.12 KOO35154.1 - 0.11 12.7 0.0 8.2 6.6 0.0 2.1 2 0 0 2 2 2 0 Sin3 associated polypeptide p18 (SAP18) Rad9_Rad53_bind PF08605.10 KOO35154.1 - 0.22 11.7 0.0 5 7.3 0.0 2.1 2 0 0 2 2 2 0 Fungal Rad9-like Rad53-binding EF-hand_6 PF13405.6 KOO35155.1 - 3.3e-11 42.2 0.4 1.5e-05 24.6 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO35155.1 - 6.5e-11 41.0 2.2 6.7e-05 22.1 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO35155.1 - 8.1e-10 39.0 0.2 1.5e-09 38.2 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO35155.1 - 5e-09 35.2 1.0 0.00018 20.8 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO35155.1 - 9.9e-07 28.5 1.2 2.7e-05 23.9 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO35155.1 - 0.0011 19.2 0.0 0.0023 18.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KOO35155.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.12 KOO35156.1 - 0.012 15.8 0.0 0.019 15.2 0.0 1.3 1 0 0 1 1 1 0 p25-alpha GLE1 PF07817.13 KOO35157.1 - 1.9e-30 105.9 0.2 3.1e-30 105.2 0.2 1.3 1 1 0 1 1 1 1 GLE1-like protein STN1_2 PF09170.10 KOO35158.1 - 0.12 12.6 0.1 13 5.9 0.0 2.2 1 1 1 2 2 2 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 CcdA PF07362.12 KOO35158.1 - 0.59 10.6 5.4 0.29 11.6 1.3 2.3 1 1 1 2 2 2 0 Post-segregation antitoxin CcdA ATP-synt_ab_C PF00306.27 KOO35159.1 - 9.8e-44 148.7 0.3 1.1e-43 148.6 0.3 1.0 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain RCC1 PF00415.18 KOO35160.1 - 1.4e-31 108.8 7.6 3.1e-09 37.3 0.0 4.5 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO35160.1 - 7.9e-14 51.0 23.5 5.6e-06 26.0 3.2 4.3 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 KOO35160.1 - 0.14 11.9 0.5 4.6 6.9 0.0 2.4 3 0 0 3 3 3 0 TUP1-like enhancer of split DUF2009 PF09418.10 KOO35161.1 - 7e-173 575.9 0.0 8e-173 575.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) CTP_transf_1 PF01148.20 KOO35162.1 - 5.6e-54 183.7 11.2 7.1e-54 183.3 11.2 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Choline_transpo PF04515.12 KOO35163.1 - 8.9e-35 120.4 5.6 8.9e-35 120.4 5.6 3.1 2 1 1 3 3 3 1 Plasma-membrane choline transporter PARP PF00644.20 KOO35164.1 - 8.6e-36 123.4 0.0 8.5e-25 87.5 0.0 2.5 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Pkinase PF00069.25 KOO35164.1 - 1.7e-19 70.3 0.0 2.9e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35164.1 - 3e-11 43.1 0.0 5.3e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase ART-PolyVal PF18760.1 KOO35164.1 - 0.052 14.6 8.6 0.39 11.7 0.0 4.1 3 2 0 3 3 3 0 ADP-Ribosyltransferase in polyvalent proteins Ribosomal_L13e PF01294.18 KOO35165.1 - 0.0035 17.2 4.0 3.6 7.4 0.2 3.5 1 1 3 4 4 4 3 Ribosomal protein L13e RPAP1_C PF08620.10 KOO35165.1 - 0.041 14.0 7.0 26 5.0 0.1 5.1 2 2 3 5 5 5 0 RPAP1-like, C-terminal MerR-DNA-bind PF09278.11 KOO35165.1 - 0.13 12.8 0.1 5.9 7.5 0.1 3.1 2 2 0 2 2 2 0 MerR, DNA binding DUF1191 PF06697.12 KOO35165.1 - 0.55 10.0 3.9 1.8 8.3 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1191) Torus PF16131.5 KOO35165.1 - 1.8 9.3 11.8 17 6.2 3.6 2.7 1 1 2 3 3 3 0 Torus domain Dickkopf_N PF04706.12 KOO35165.1 - 6.8 7.3 9.3 14 6.3 0.5 2.8 2 1 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region DDE_1 PF03184.19 KOO35166.1 - 0.00018 21.2 0.0 0.00034 20.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2505 PF10698.9 KOO35167.1 - 7.2e-05 22.9 0.0 9.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) PX PF00787.24 KOO35168.1 - 2.6e-10 40.2 0.1 3.7e-10 39.8 0.1 1.2 1 0 0 1 1 1 1 PX domain Urb2 PF10441.9 KOO35170.1 - 1.3e-12 48.2 0.0 1.3e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 Urb2/Npa2 family Glyco_transf_15 PF01793.16 KOO35174.1 - 0.0029 16.9 0.1 0.0039 16.5 0.1 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TraG-D_C PF12696.7 KOO35174.1 - 0.054 13.5 0.1 0.14 12.2 0.1 1.6 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG IPK PF03770.16 KOO35175.1 - 8.2e-14 51.9 0.0 1.4e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Pkinase PF00069.25 KOO35175.1 - 3.4e-13 49.6 0.0 6.2e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain LRR_6 PF13516.6 KOO35175.1 - 3.3e-10 39.2 0.1 0.0086 16.1 0.0 3.7 3 0 0 3 3 3 2 Leucine Rich repeat Pkinase_Tyr PF07714.17 KOO35175.1 - 0.028 13.7 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase NACHT PF05729.12 KOO35177.1 - 5.5e-09 36.2 0.0 2.2e-08 34.2 0.0 2.1 2 0 0 2 2 1 1 NACHT domain AAA_22 PF13401.6 KOO35177.1 - 9.7e-05 22.7 0.5 0.0049 17.1 0.1 3.8 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 KOO35177.1 - 0.00054 20.4 0.0 0.00054 20.4 0.0 4.5 3 1 1 4 4 4 1 AAA ATPase domain T2SSE PF00437.20 KOO35177.1 - 0.0048 16.0 0.3 0.028 13.5 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 KOO35177.1 - 0.0066 15.8 0.0 0.0066 15.8 0.0 2.7 3 0 0 3 3 3 1 FtsK/SpoIIIE family Viral_helicase1 PF01443.18 KOO35177.1 - 0.008 15.9 0.0 0.022 14.5 0.0 1.7 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase ATP_bind_1 PF03029.17 KOO35177.1 - 0.019 14.8 0.2 0.11 12.2 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Spidroin_MaSp PF11260.8 KOO35177.1 - 0.027 14.8 0.6 0.12 12.7 0.6 2.1 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 AAA_29 PF13555.6 KOO35177.1 - 0.031 14.0 0.0 0.08 12.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 KOO35177.1 - 0.045 14.3 0.1 0.41 11.2 0.0 2.9 3 0 0 3 3 1 0 AAA domain PPV_E1_C PF00519.17 KOO35177.1 - 0.054 12.3 0.0 0.17 10.7 0.0 1.7 2 0 0 2 2 2 0 Papillomavirus helicase KAP_NTPase PF07693.14 KOO35177.1 - 0.06 12.6 1.7 0.23 10.6 0.0 2.6 2 1 0 2 2 2 0 KAP family P-loop domain DUF2075 PF09848.9 KOO35177.1 - 0.081 12.1 0.2 0.41 9.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Pox_A32 PF04665.12 KOO35177.1 - 0.089 12.2 0.0 0.23 10.9 0.0 1.7 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.20 KOO35177.1 - 0.1 11.7 0.0 0.28 10.3 0.0 1.7 1 0 0 1 1 1 0 G-protein alpha subunit ATPase PF06745.13 KOO35177.1 - 0.14 11.4 0.2 1.3 8.3 0.0 2.6 3 0 0 3 3 3 0 KaiC RNA_helicase PF00910.22 KOO35177.1 - 0.16 12.3 0.0 1.2 9.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase DYW_deaminase PF14432.6 KOO35177.1 - 0.19 11.6 1.6 0.35 10.7 0.5 2.0 2 0 0 2 2 2 0 DYW family of nucleic acid deaminases DUF87 PF01935.17 KOO35177.1 - 0.6 10.2 3.6 2.4 8.2 0.0 3.2 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_19 PF13245.6 KOO35177.1 - 0.88 9.9 0.0 0.88 9.9 0.0 3.1 3 2 0 3 3 3 0 AAA domain Condensin2nSMC PF12422.8 KOO35178.1 - 3.5e-52 176.5 0.0 2.4e-51 173.8 0.0 2.4 3 0 0 3 3 3 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 KOO35178.1 - 0.0061 16.7 12.0 0.29 11.5 0.4 5.5 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 KOO35178.1 - 0.0076 16.7 0.2 0.0076 16.7 0.2 5.7 4 2 0 4 4 4 1 HEAT-like repeat Adaptin_N PF01602.20 KOO35178.1 - 0.02 13.5 0.0 0.063 11.8 0.0 1.8 1 1 0 1 1 1 0 Adaptin N terminal region Het-C PF07217.11 KOO35178.1 - 0.15 10.6 0.0 0.2 10.1 0.0 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Spindle_Spc25 PF08234.12 KOO35180.1 - 4.5e-19 68.4 0.0 1.2e-18 67.1 0.0 1.8 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 RTBV_P46 PF06216.11 KOO35180.1 - 0.065 12.1 0.2 0.21 10.4 0.1 1.7 1 1 1 2 2 2 0 Rice tungro bacilliform virus P46 protein Exonuc_VII_L PF02601.15 KOO35180.1 - 0.19 11.3 8.9 0.84 9.2 8.4 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit TolA_bind_tri PF16331.5 KOO35180.1 - 0.53 10.4 19.1 0.77 9.9 0.3 4.1 2 1 2 4 4 4 0 TolA binding protein trimerisation HALZ PF02183.18 KOO35180.1 - 0.84 9.9 9.5 0.16 12.2 0.6 3.4 4 0 0 4 4 3 0 Homeobox associated leucine zipper DUF4407 PF14362.6 KOO35180.1 - 1.2 8.5 8.8 2.2 7.6 8.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Lectin_N PF03954.14 KOO35180.1 - 2 8.2 7.6 14 5.4 7.6 2.2 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain FlaC_arch PF05377.11 KOO35180.1 - 3 8.3 9.6 1.7 9.1 0.6 3.7 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 KOO35180.1 - 3.7 6.7 8.9 3.1 7.0 7.6 1.4 1 1 0 1 1 1 0 TMPIT-like protein Spc7 PF08317.11 KOO35180.1 - 4.1 6.2 17.6 9.2 5.0 17.6 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 KOO35180.1 - 4.8 6.2 11.3 7.3 5.6 11.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_23 PF13476.6 KOO35180.1 - 5.1 7.5 6.5 8 6.9 6.5 1.3 1 0 0 1 1 1 0 AAA domain ADIP PF11559.8 KOO35180.1 - 5.5 7.1 14.8 2.4 8.2 12.0 1.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF5320 PF17253.2 KOO35180.1 - 6.5 7.9 0.0 6.5 7.9 0.0 3.2 2 1 0 2 2 1 0 Family of unknown function (DUF5320) YabA PF06156.13 KOO35180.1 - 6.5 7.4 11.9 11 6.7 4.5 2.8 1 1 1 2 2 2 0 Initiation control protein YabA NDK PF00334.19 KOO35181.1 - 2.3e-33 115.1 0.0 1.8e-32 112.2 0.0 1.9 1 1 0 1 1 1 1 Nucleoside diphosphate kinase Mpv17_PMP22 PF04117.12 KOO35184.1 - 0.038 14.2 0.1 0.038 14.2 0.1 2.0 2 0 0 2 2 2 0 Mpv17 / PMP22 family Peptidase_S8 PF00082.22 KOO35188.1 - 2.6e-07 30.2 0.0 3.7e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Subtilase family PT PF04886.12 KOO35188.1 - 0.29 10.7 9.4 0.56 9.8 9.4 1.5 1 0 0 1 1 1 0 PT repeat Arm PF00514.23 KOO35190.1 - 1.3e-36 123.5 17.0 2.1e-09 37.1 0.3 5.4 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat U-box PF04564.15 KOO35190.1 - 7e-14 51.8 0.5 3.2e-13 49.7 0.0 2.3 4 0 0 4 4 2 1 U-box domain Atx10homo_assoc PF09759.9 KOO35190.1 - 8.2e-10 38.6 0.0 0.0068 16.4 0.0 3.4 1 1 3 4 4 4 4 Spinocerebellar ataxia type 10 protein domain zf-Nse PF11789.8 KOO35190.1 - 1.1e-05 25.1 0.0 2.1e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Arm_2 PF04826.13 KOO35190.1 - 0.00013 21.6 0.0 0.35 10.3 0.0 3.1 1 1 2 3 3 3 2 Armadillo-like zf-NOSIP PF15906.5 KOO35190.1 - 0.0023 18.0 0.0 0.0052 16.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein DUF5631 PF18645.1 KOO35190.1 - 0.0036 17.6 0.6 0.018 15.4 0.6 2.2 1 0 0 1 1 1 1 Family of unknown function (DUF5631) DUF4449 PF14613.6 KOO35190.1 - 0.049 13.7 0.1 0.095 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) zf-RING_UBOX PF13445.6 KOO35190.1 - 0.053 13.6 0.0 0.094 12.8 0.0 1.4 1 0 0 1 1 1 0 RING-type zinc-finger GlutR_dimer PF00745.20 KOO35190.1 - 0.064 13.7 9.8 7.3 7.1 0.0 4.8 2 1 3 5 5 5 0 Glutamyl-tRNAGlu reductase, dimerisation domain V-ATPase_H_N PF03224.14 KOO35190.1 - 0.19 11.0 0.0 0.46 9.7 0.0 1.6 1 1 0 1 1 1 0 V-ATPase subunit H CCDC144C PF14915.6 KOO35190.1 - 0.28 10.3 2.8 0.47 9.5 2.8 1.2 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Succ_CoA_lig PF13607.6 KOO35190.1 - 0.34 10.7 10.3 2 8.2 0.5 3.8 1 1 3 4 4 4 0 Succinyl-CoA ligase like flavodoxin domain Robl_LC7 PF03259.17 KOO35190.1 - 0.97 9.3 4.4 1.3 8.8 1.5 2.5 2 0 0 2 2 2 0 Roadblock/LC7 domain U-box PF04564.15 KOO35191.1 - 1.9e-05 24.7 0.0 3.2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 KOO35191.1 - 0.008 16.3 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Dynamin_N PF00350.23 KOO35191.1 - 0.016 15.3 0.1 0.023 14.8 0.1 1.3 1 0 0 1 1 1 0 Dynamin family TniB PF05621.11 KOO35191.1 - 0.016 14.6 0.0 0.43 10.0 0.0 2.0 1 1 1 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 KOO35191.1 - 0.054 13.9 0.6 0.32 11.3 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.18 KOO35191.1 - 0.098 12.6 0.0 0.15 12.0 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea TFA2_Winged_2 PF18121.1 KOO35191.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.8 1 1 0 1 1 1 0 TFA2 Winged helix domain 2 Ank_2 PF12796.7 KOO35193.1 - 8.2e-23 80.8 0.0 4.8e-12 46.3 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO35193.1 - 5.4e-19 67.7 0.1 2.6e-05 24.5 0.0 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO35193.1 - 9.4e-17 60.9 0.0 7.2e-06 26.2 0.0 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO35193.1 - 1.6e-13 50.9 0.0 1.9e-06 28.3 0.0 3.3 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35193.1 - 1.1e-12 46.9 0.0 0.00088 19.6 0.0 4.2 3 1 0 3 3 3 3 Ankyrin repeat PEGA PF08308.11 KOO35193.1 - 0.14 12.1 0.3 3.1 7.7 0.0 2.7 2 1 1 3 3 3 0 PEGA domain HELP PF03451.14 KOO35194.1 - 1.3e-16 60.2 0.1 1.9e-16 59.6 0.1 1.3 1 0 0 1 1 1 1 HELP motif WD40 PF00400.32 KOO35196.1 - 1.2e-27 95.5 16.5 0.029 15.2 0.0 10.4 10 0 0 10 10 10 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO35196.1 - 1e-11 44.9 0.0 0.0049 17.1 0.0 6.0 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOO35196.1 - 0.002 18.0 0.0 2.9 8.0 0.0 3.4 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 KOO35196.1 - 0.037 13.0 0.1 13 4.6 0.0 3.7 5 1 1 6 6 6 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HPS3_N PF14761.6 KOO35196.1 - 0.18 11.3 0.0 0.84 9.1 0.0 2.1 3 0 0 3 3 3 0 Hermansky-Pudlak syndrome 3 Glyco_hydro_65C PF03633.15 KOO35197.1 - 0.0034 17.3 0.1 12 5.8 0.0 3.4 2 1 1 3 3 3 3 Glycosyl hydrolase family 65, C-terminal domain DnaJ_C PF01556.18 KOO35197.1 - 0.029 14.5 0.0 0.53 10.4 0.0 2.3 1 1 1 2 2 2 0 DnaJ C terminal domain Adaptin_N PF01602.20 KOO35198.1 - 5.8e-114 381.5 5.1 7.7e-114 381.1 5.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 KOO35198.1 - 7.4e-40 136.5 0.0 1.9e-39 135.2 0.0 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 KOO35198.1 - 9.3e-30 103.1 0.0 1.9e-29 102.1 0.0 1.6 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 KOO35198.1 - 3.4e-14 53.0 5.2 5.5e-06 26.7 0.0 5.8 4 1 2 6 6 6 3 HEAT repeats Cnd1 PF12717.7 KOO35198.1 - 3.9e-13 49.8 9.1 2.6e-07 30.8 0.4 4.4 2 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KOO35198.1 - 0.00036 21.0 8.2 0.14 12.7 0.0 5.6 4 1 1 5 5 5 1 HEAT-like repeat HEAT PF02985.22 KOO35198.1 - 0.00068 19.7 7.5 4.8 7.7 0.0 6.3 6 0 0 6 6 6 1 HEAT repeat Cnd3 PF12719.7 KOO35198.1 - 0.017 14.4 0.4 3.7 6.7 0.1 2.9 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain RICTOR_M PF14666.6 KOO35198.1 - 0.029 14.1 0.3 0.82 9.5 0.1 3.2 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain UNC45-central PF11701.8 KOO35198.1 - 0.059 13.3 0.3 1.4 8.9 0.0 3.1 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central RTP1_C1 PF10363.9 KOO35198.1 - 0.2 11.9 3.9 4.6 7.5 0.3 3.9 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 LSM14 PF12701.7 KOO35200.1 - 9.5e-32 108.9 0.0 1.1e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 KOO35200.1 - 4.2e-08 33.2 0.0 5.3e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain Ank_2 PF12796.7 KOO35201.1 - 1.8e-28 98.9 0.0 1.6e-11 44.6 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO35201.1 - 8.1e-22 77.3 0.2 7.5e-06 26.4 0.0 5.9 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO35201.1 - 3.9e-19 68.2 3.7 0.065 13.7 0.0 8.1 8 0 0 8 8 8 5 Ankyrin repeat Ank_3 PF13606.6 KOO35201.1 - 5e-19 66.4 3.7 0.069 13.7 0.0 8.3 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 KOO35201.1 - 8.1e-18 64.3 5.2 0.00037 20.7 0.1 7.5 7 1 1 8 8 8 4 Ankyrin repeats (many copies) DUF1682 PF07946.14 KOO35201.1 - 0.00017 20.9 10.3 0.00029 20.2 10.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DnaJ PF00226.31 KOO35202.1 - 2.1e-18 66.2 1.2 4e-18 65.3 1.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 KOO35202.1 - 4.8e-11 43.0 0.0 8.3e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain Nucleotid_trans PF03407.16 KOO35203.1 - 6.9e-28 98.1 0.1 7e-27 94.8 0.1 2.1 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase O-FucT PF10250.9 KOO35203.1 - 0.056 13.1 0.0 0.092 12.4 0.0 1.2 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase PRT_C PF08372.10 KOO35203.1 - 0.07 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal F5_F8_type_C PF00754.25 KOO35204.1 - 2.7e-14 53.4 0.1 2.3e-12 47.1 0.0 2.6 2 0 0 2 2 2 2 F5/8 type C domain DUF2357 PF09823.9 KOO35205.1 - 0.075 12.3 0.1 0.25 10.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2357) Lzipper-MIP1 PF14389.6 KOO35205.1 - 0.087 13.1 0.7 0.49 10.7 0.1 2.5 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Rotamase_3 PF13616.6 KOO35205.1 - 0.13 12.9 0.0 0.25 11.9 0.0 1.5 1 0 0 1 1 1 0 PPIC-type PPIASE domain Hox9_act PF04617.13 KOO35205.1 - 0.22 12.3 0.0 0.36 11.6 0.0 1.4 1 0 0 1 1 1 0 Hox9 activation region YicC_N PF03755.13 KOO35206.1 - 6.8e-05 23.4 2.0 2.1 8.8 0.0 3.7 4 0 0 4 4 4 2 YicC-like family, N-terminal region Fmp27_SW PF10305.9 KOO35206.1 - 0.012 16.3 0.3 1 10.1 0.0 2.6 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain T7SS_ESX_EspC PF10824.8 KOO35206.1 - 0.1 13.1 2.1 19 5.8 0.2 2.8 2 0 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm T6PP_N PF18572.1 KOO35206.1 - 0.13 12.1 3.1 3.1 7.7 0.2 3.3 5 0 0 5 5 5 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain FUSC PF04632.12 KOO35206.1 - 0.17 10.4 4.1 3.9 5.9 0.2 2.5 2 1 0 2 2 2 0 Fusaric acid resistance protein family DUF4795 PF16043.5 KOO35206.1 - 1.2 8.7 6.7 2.7 7.6 0.6 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) RicinB_lectin_2 PF14200.6 KOO35207.1 - 2e-06 28.4 0.8 0.0071 17.1 0.1 2.2 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Motile_Sperm PF00635.26 KOO35207.1 - 0.2 11.5 0.0 13 5.7 0.0 2.8 2 1 1 3 3 3 0 MSP (Major sperm protein) domain Orthopox_C10L PF07020.11 KOO35208.1 - 0.012 16.4 0.9 0.019 15.7 0.9 1.3 1 0 0 1 1 1 0 Orthopoxvirus C10L protein PreAtp-grasp PF18604.1 KOO35210.1 - 0.015 14.9 0.0 8.9 5.9 0.0 2.8 2 0 0 2 2 2 0 Pre ATP-grasp domain CAP_N PF01213.19 KOO35210.1 - 2.7 7.4 6.6 11 5.4 0.8 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Coprogen_oxidas PF01218.18 KOO35212.1 - 3.8e-134 446.1 0.1 4.4e-134 445.8 0.1 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase ShK PF01549.24 KOO35213.1 - 1.4e-06 28.7 7.2 1.4e-06 28.7 7.2 2.4 3 0 0 3 3 3 1 ShK domain-like RWD PF05773.22 KOO35215.1 - 6.8e-09 36.0 0.0 8.9e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 RWD domain DUF5486 PF17588.2 KOO35215.1 - 0.036 13.9 0.1 0.065 13.1 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5486) zf_Rg PF17915.1 KOO35215.1 - 0.085 12.3 0.5 0.16 11.4 0.5 1.4 1 0 0 1 1 1 0 Reverse gyrase zinc finger EF-hand_6 PF13405.6 KOO35216.1 - 4.5e-09 35.5 0.2 8.7e-06 25.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO35216.1 - 5.3e-09 35.0 0.1 8.4e-06 25.0 0.0 3.0 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KOO35216.1 - 9.2e-08 32.4 0.1 2.2e-07 31.2 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO35216.1 - 2.9e-07 29.7 0.2 0.00029 20.2 0.1 2.5 2 0 0 2 2 2 2 EF hand PDZ_6 PF17820.1 KOO35216.1 - 4.5e-07 29.6 0.1 1.4e-06 28.0 0.1 1.9 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO35216.1 - 3.4e-05 24.1 0.0 0.00011 22.4 0.0 1.9 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO35216.1 - 0.00014 22.1 0.0 0.00035 20.8 0.0 1.7 1 0 0 1 1 1 1 PDZ domain EF-hand_8 PF13833.6 KOO35216.1 - 0.00053 19.8 0.1 0.005 16.6 0.0 2.5 2 1 1 3 3 3 2 EF-hand domain pair Hamartin PF04388.12 KOO35216.1 - 8.9 4.8 6.5 10 4.6 6.5 1.2 1 0 0 1 1 1 0 Hamartin protein Mito_carr PF00153.27 KOO35218.1 - 5.2e-36 122.4 6.2 7.2e-19 67.5 0.2 4.2 3 2 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOO35218.1 - 0.12 11.6 0.7 0.39 9.8 0.0 2.1 3 0 0 3 3 3 0 Gammaproteobacterial serine protease Synaptobrevin PF00957.21 KOO35220.1 - 2.5e-16 59.2 0.1 4.2e-16 58.5 0.1 1.4 1 0 0 1 1 1 1 Synaptobrevin DUF4633 PF15464.6 KOO35220.1 - 0.0092 16.1 0.1 0.02 15.0 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4633) Longin PF13774.6 KOO35220.1 - 0.072 13.1 0.1 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Regulated-SNARE-like domain PsaN PF05479.11 KOO35220.1 - 0.087 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) TPH PF13868.6 KOO35221.1 - 6.5e-33 113.7 59.9 6.5e-33 113.7 59.9 2.0 1 1 0 1 1 1 1 Trichohyalin-plectin-homology domain NHL PF01436.21 KOO35222.1 - 1.1e-36 123.1 6.2 2.1e-08 33.8 0.0 5.5 5 0 0 5 5 5 5 NHL repeat BTB PF00651.31 KOO35222.1 - 1.1e-19 70.6 0.1 1.9e-19 69.9 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain SGL PF08450.12 KOO35222.1 - 4.4e-15 55.9 10.6 0.0002 21.0 0.1 4.7 3 2 2 5 5 5 4 SMP-30/Gluconolactonase/LRE-like region DUF839 PF05787.13 KOO35222.1 - 1.5e-10 40.9 2.8 0.013 14.7 0.1 3.8 1 1 3 4 4 4 3 Bacterial protein of unknown function (DUF839) Phytase-like PF13449.6 KOO35222.1 - 2.1e-05 24.6 0.1 0.13 12.2 0.0 3.1 1 1 1 3 3 3 2 Esterase-like activity of phytase SBBP PF06739.11 KOO35222.1 - 0.014 15.4 4.5 15 5.7 0.0 4.8 5 0 0 5 5 5 0 Beta-propeller repeat SdiA-regulated PF06977.11 KOO35222.1 - 0.029 13.6 0.0 7.7 5.7 0.0 2.7 3 1 0 3 3 3 0 SdiA-regulated Ldl_recept_b PF00058.17 KOO35222.1 - 0.13 12.8 4.5 36 5.0 0.0 4.8 5 0 0 5 5 5 0 Low-density lipoprotein receptor repeat class B EF-hand_1 PF00036.32 KOO35223.1 - 1.5e-28 96.2 6.2 1.5e-07 30.5 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO35223.1 - 1e-24 86.8 1.8 6.6e-11 42.5 0.0 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO35223.1 - 1.5e-22 78.0 5.2 0.00011 21.5 0.4 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO35223.1 - 5.1e-20 69.6 0.3 0.0031 17.3 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO35223.1 - 4.2e-16 58.5 9.1 4e-07 29.8 0.2 4.3 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KOO35223.1 - 1.8e-08 34.5 0.7 0.00031 21.0 0.0 2.6 3 0 0 3 3 2 2 EF-hand domain EF-hand_4 PF12763.7 KOO35223.1 - 1.7e-07 31.2 0.3 0.01 15.8 0.0 3.2 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO35223.1 - 2.3e-06 27.9 0.0 0.054 13.8 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO35223.1 - 8.2e-05 22.7 2.5 0.21 11.8 0.4 3.0 2 1 1 3 3 3 2 Dockerin type I domain p25-alpha PF05517.12 KOO35223.1 - 0.02 15.0 0.0 0.31 11.2 0.0 2.3 2 0 0 2 2 2 0 p25-alpha AP_endonuc_2_N PF07582.12 KOO35223.1 - 0.11 12.2 0.3 60 3.5 0.1 3.7 3 0 0 3 3 3 0 AP endonuclease family 2 C terminus EF-hand_10 PF14788.6 KOO35223.1 - 0.41 10.5 1.0 59 3.6 0.0 3.2 4 0 0 4 4 4 0 EF hand DUF4440 PF14534.6 KOO35223.1 - 4.2 7.8 5.5 12 6.3 0.8 3.3 2 2 0 2 2 2 0 Domain of unknown function (DUF4440) DnaJ_C PF01556.18 KOO35224.1 - 1.8e-24 86.5 0.0 2.5e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOO35224.1 - 2.6e-14 53.1 0.0 4.6e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain AA_permease PF00324.21 KOO35228.1 - 2.2e-49 168.4 36.1 5.6e-49 167.0 36.1 1.6 1 1 0 1 1 1 1 Amino acid permease Peptidase_M10_C PF08548.11 KOO35229.1 - 0.029 14.3 3.7 36 4.2 0.0 4.9 1 1 5 6 6 6 0 Peptidase M10 serralysin C terminal tRNA_edit PF04073.15 KOO35229.1 - 0.15 12.2 0.2 8.1 6.6 0.1 3.2 1 1 1 2 2 2 0 Aminoacyl-tRNA editing domain DUF2740 PF10872.8 KOO35229.1 - 0.95 9.4 7.7 23 5.0 0.0 4.7 5 1 0 5 5 5 0 Protein of unknown function (DUF2740) LRR_6 PF13516.6 KOO35231.1 - 1e-47 156.2 26.1 3.1e-05 23.7 0.1 12.0 12 0 0 12 12 12 10 Leucine Rich repeat LRR_4 PF12799.7 KOO35231.1 - 9.1e-06 25.9 16.4 2.3 8.8 0.0 8.4 4 3 6 10 10 10 1 Leucine Rich repeats (2 copies) EIF_2_alpha PF07541.12 KOO35231.1 - 0.0083 16.2 1.4 1.7 8.8 0.3 3.8 1 1 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit YusW PF14039.6 KOO35231.1 - 0.039 14.5 3.6 39 4.8 0.0 4.7 4 2 2 6 6 6 0 YusW-like protein CbiG_N PF11760.8 KOO35231.1 - 0.16 12.0 16.8 18 5.4 0.1 6.8 7 0 0 7 7 7 0 Cobalamin synthesis G N-terminal DUF2202 PF09968.9 KOO35231.1 - 1.3 8.8 4.0 42 3.9 0.1 3.9 1 1 3 5 5 5 0 Uncharacterized protein domain (DUF2202) Arm-DNA-bind_1 PF09003.10 KOO35231.1 - 7.8 6.7 25.8 9.5 6.5 0.2 7.0 2 1 7 9 9 9 0 Bacteriophage lambda integrase, Arm DNA-binding domain Ammonium_transp PF00909.21 KOO35232.1 - 5.6e-99 331.5 27.9 1.9e-98 329.8 27.9 1.6 1 1 0 1 1 1 1 Ammonium Transporter Family NqrM PF04400.13 KOO35232.1 - 0.13 12.0 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 (Na+)-NQR maturation NqrM Glyco_hydro_3 PF00933.21 KOO35233.1 - 3.6e-35 121.8 0.0 5.8e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 KOO35233.1 - 1.1e-13 51.6 0.0 7.1e-07 29.4 0.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 KOO35233.1 - 1.2e-09 38.1 0.1 2.7e-09 37.0 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF3337 PF11816.8 KOO35235.1 - 7.8e-26 91.0 0.0 3.2e-25 89.0 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 KOO35235.1 - 4.3e-21 74.8 17.4 0.00078 20.2 0.1 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat KLRAQ PF10205.9 KOO35235.1 - 0.039 14.2 0.2 0.089 13.0 0.2 1.5 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Fez1 PF06818.15 KOO35235.1 - 0.043 14.3 0.5 0.043 14.3 0.5 1.6 2 0 0 2 2 2 0 Fez1 Nucleoporin_N PF08801.11 KOO35235.1 - 0.076 11.8 0.2 2.7 6.7 0.0 2.3 2 0 0 2 2 2 0 Nup133 N terminal like ATG16 PF08614.11 KOO35235.1 - 0.08 13.2 15.3 0.13 12.4 15.3 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) WD40_like PF17005.5 KOO35235.1 - 0.089 12.1 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 WD40-like domain DUF1640 PF07798.11 KOO35235.1 - 0.3 11.1 6.5 0.21 11.6 4.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DivIC PF04977.15 KOO35235.1 - 0.51 10.1 7.6 0.052 13.3 2.5 2.0 2 0 0 2 2 2 0 Septum formation initiator WXG100 PF06013.12 KOO35235.1 - 0.65 10.3 5.1 1.8 8.9 0.5 2.7 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DUF4200 PF13863.6 KOO35235.1 - 4.7 7.6 8.6 11 6.4 4.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) SepSecS PF05889.13 KOO35236.1 - 2.4e-97 326.1 0.0 8.6e-53 179.4 0.0 2.0 1 1 1 2 2 2 2 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DUF2559 PF10832.8 KOO35237.1 - 0.094 12.8 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2559) Lactonase PF10282.9 KOO35239.1 - 1.3e-57 195.7 0.0 3.7e-55 187.6 0.0 2.3 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Topoisom_bac PF01131.20 KOO35242.1 - 2.7e-55 188.1 0.0 7.3e-42 143.8 0.0 3.1 3 0 0 3 3 3 3 DNA topoisomerase Rotamase_3 PF13616.6 KOO35242.1 - 3.8e-14 53.2 0.0 7.9e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 KOO35242.1 - 1.1e-13 51.9 2.2 5.4e-13 49.7 0.0 2.9 3 0 0 3 3 3 1 PPIC-type PPIASE domain Toprim PF01751.22 KOO35242.1 - 3e-07 30.6 0.0 1.1e-06 28.8 0.0 1.9 2 0 0 2 2 2 1 Toprim domain Cellulase PF00150.18 KOO35245.1 - 8.3e-31 107.4 0.0 1.2e-30 106.9 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 KOO35245.1 - 0.0049 16.0 0.0 0.0076 15.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain ALAD PF00490.21 KOO35246.1 - 3.8e-136 453.4 0.0 4.5e-136 453.2 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase EF-hand_1 PF00036.32 KOO35248.1 - 1.7e-13 49.1 0.7 2e-05 23.8 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO35248.1 - 1.9e-09 36.7 0.1 0.00011 21.9 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO35248.1 - 5.5e-09 35.7 1.6 3.5e-06 26.8 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO35248.1 - 7.7e-09 35.9 0.1 1.3e-08 35.2 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO35248.1 - 1.8e-08 33.5 0.3 0.0039 16.6 0.0 2.4 2 0 0 2 2 2 2 EF hand DUF4381 PF14316.6 KOO35248.1 - 0.0098 16.1 3.3 0.95 9.7 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4381) EF-hand_4 PF12763.7 KOO35248.1 - 0.059 13.3 0.0 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF5580 PF17743.1 KOO35248.1 - 0.068 11.7 0.0 0.1 11.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) SPARC_Ca_bdg PF10591.9 KOO35248.1 - 0.19 12.1 0.0 0.33 11.3 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Filamin PF00630.19 KOO35249.1 - 3.8e-48 162.6 0.1 1.1e-13 51.8 0.0 7.3 6 1 1 7 7 7 6 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO35249.1 - 5.6e-10 39.4 0.8 0.021 15.1 0.0 4.9 5 0 0 5 5 5 3 Invasin, domain 3 DUF5060 PF16586.5 KOO35249.1 - 0.071 13.5 0.3 6.9 7.1 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) Macoilin PF09726.9 KOO35249.1 - 5.6 5.4 10.1 8.4 4.8 10.1 1.1 1 0 0 1 1 1 0 Macoilin family Arm PF00514.23 KOO35250.1 - 3.2e-13 49.2 7.9 7.7e-05 22.6 0.0 4.7 4 1 0 4 4 4 3 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 KOO35250.1 - 0.15 11.3 0.0 0.29 10.4 0.0 1.5 2 0 0 2 2 2 0 V-ATPase subunit H Arm PF00514.23 KOO35251.1 - 4.8e-33 112.2 26.2 2e-05 24.4 0.1 12.5 13 0 0 13 13 13 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO35251.1 - 0.0034 17.8 23.4 0.78 10.3 0.5 6.2 6 0 0 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 KOO35251.1 - 0.028 14.8 0.1 0.028 14.8 0.1 5.8 3 3 1 4 4 4 0 HEAT repeats V-ATPase_H_N PF03224.14 KOO35251.1 - 0.13 11.5 0.0 6.6 5.9 0.0 2.2 2 0 0 2 2 2 0 V-ATPase subunit H HEAT PF02985.22 KOO35251.1 - 0.25 11.7 0.0 0.25 11.7 0.0 5.3 7 0 0 7 7 7 0 HEAT repeat S4 PF01479.25 KOO35252.1 - 5.1e-14 51.7 0.4 1.5e-13 50.3 0.4 1.8 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 KOO35252.1 - 5.8e-07 30.3 0.6 9.4e-07 29.7 0.3 1.7 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain LRR_6 PF13516.6 KOO35253.1 - 3.8e-09 35.9 18.5 0.072 13.2 0.2 9.3 11 0 0 11 11 11 4 Leucine Rich repeat LRR_1 PF00560.33 KOO35253.1 - 2.7e-08 33.2 3.6 11 7.0 0.1 8.4 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_4 PF12799.7 KOO35253.1 - 0.00043 20.6 7.8 7.2 7.2 0.0 7.2 7 1 1 8 8 8 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO35253.1 - 0.049 13.4 6.5 31 4.4 1.4 6.7 6 2 1 7 7 7 0 Leucine rich repeat Fasciclin PF02469.22 KOO35254.1 - 1.9e-10 41.1 0.0 3.1e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain WD40 PF00400.32 KOO35255.1 - 2.1e-22 79.0 16.1 0.00065 20.5 0.5 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ATP-gua_PtransN PF02807.15 KOO35255.1 - 1.7e-12 47.5 0.0 3.5e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain LRR_6 PF13516.6 KOO35255.1 - 2.3e-10 39.7 11.0 0.16 12.1 0.1 9.0 11 0 0 11 11 11 3 Leucine Rich repeat SPRY PF00622.28 KOO35255.1 - 1.5e-07 31.5 0.0 3.3e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 SPRY domain LRR_4 PF12799.7 KOO35255.1 - 3.8e-05 24.0 0.3 27 5.4 0.0 6.1 6 2 1 7 7 7 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO35255.1 - 0.00023 21.3 0.0 1.1e+02 4.0 0.0 6.8 9 0 0 9 9 9 0 Leucine Rich Repeat ANAPC4_WD40 PF12894.7 KOO35255.1 - 0.0029 17.9 0.0 0.84 10.0 0.0 2.9 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Shikimate_dh_N PF08501.11 KOO35256.1 - 4e-17 62.2 0.0 1.5e-16 60.4 0.0 1.9 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 KOO35256.1 - 0.0012 18.6 0.2 0.0026 17.5 0.2 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain LRR_6 PF13516.6 KOO35257.1 - 9.3e-23 78.3 10.1 0.00031 20.5 0.0 6.4 6 0 0 6 6 6 5 Leucine Rich repeat SAP PF02037.27 KOO35257.1 - 2e-07 30.6 0.2 6.5e-07 29.0 0.2 1.9 1 0 0 1 1 1 1 SAP domain LRR_4 PF12799.7 KOO35257.1 - 0.069 13.6 0.2 83 3.8 0.0 3.8 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) HOASN PF14515.6 KOO35257.1 - 1.1 9.7 9.9 13 6.3 0.2 4.1 1 1 2 3 3 3 0 Haem-oxygenase-associated N-terminal helices LRR_6 PF13516.6 KOO35258.1 - 1.3e-06 28.0 0.2 0.00019 21.2 0.0 2.5 2 0 0 2 2 2 1 Leucine Rich repeat DUF2358 PF10184.9 KOO35258.1 - 4.8e-05 23.6 0.0 7.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) LRR_4 PF12799.7 KOO35258.1 - 0.02 15.3 0.0 0.053 14.0 0.0 1.7 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO35258.1 - 0.11 13.1 0.0 7.2 7.6 0.0 2.9 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_6 PF13516.6 KOO35259.1 - 4.1e-08 32.6 8.9 0.064 13.3 0.1 6.8 7 0 0 7 7 7 3 Leucine Rich repeat WD40 PF00400.32 KOO35259.1 - 6.7e-05 23.6 0.6 0.23 12.4 0.0 3.5 4 0 0 4 4 4 2 WD domain, G-beta repeat EF-hand_6 PF13405.6 KOO35260.1 - 8.3e-21 72.1 2.3 1.4e-05 24.6 0.3 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO35260.1 - 9.2e-20 68.7 6.8 9.6e-06 24.8 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO35260.1 - 8.3e-16 56.7 8.0 0.0011 18.4 0.5 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO35260.1 - 3.3e-14 53.1 1.0 4.5e-07 30.2 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO35260.1 - 2.7e-06 27.1 10.3 0.019 14.8 0.3 4.1 3 1 1 4 4 4 2 EF-hand domain pair LRR_4 PF12799.7 KOO35260.1 - 3.7e-06 27.2 0.4 0.17 12.4 0.0 2.8 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO35260.1 - 0.0021 17.8 0.4 0.16 11.8 0.2 2.6 2 0 0 2 2 2 1 Leucine rich repeat Glutaredoxin2_C PF04399.13 KOO35260.1 - 0.02 14.7 0.8 0.77 9.6 0.1 3.0 3 0 0 3 3 3 0 Glutaredoxin 2, C terminal domain Ydc2-catalyt PF09159.10 KOO35261.1 - 0.0001 22.1 2.4 0.00013 21.8 2.4 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 DUF3391 PF11871.8 KOO35261.1 - 0.019 15.5 0.5 0.026 15.1 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF4108 PF13390.6 KOO35261.1 - 0.13 12.2 0.5 0.13 12.2 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4108) Vps16_C PF04840.12 KOO35262.1 - 7e-62 209.3 0.0 8.5e-62 209.0 0.0 1.0 1 0 0 1 1 1 1 Vps16, C-terminal region YqaJ PF09588.10 KOO35264.1 - 3.1e-05 24.1 0.0 5.2e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain Filamin PF00630.19 KOO35267.1 - 9.2e-11 42.5 0.0 5.5e-08 33.6 0.0 2.5 2 0 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO35267.1 - 0.00086 19.6 0.1 0.0024 18.1 0.1 1.7 1 0 0 1 1 1 1 Invasin, domain 3 Dam PF05869.11 KOO35267.1 - 0.0029 17.2 0.0 0.01 15.4 0.0 1.8 2 0 0 2 2 2 1 DNA N-6-adenine-methyltransferase (Dam) ABC_tran PF00005.27 KOO35268.1 - 6.4e-42 143.3 0.0 6.6e-21 75.3 0.0 3.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO35268.1 - 1.1e-16 61.5 0.4 0.00021 21.2 0.1 4.2 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO35268.1 - 4e-08 33.0 0.6 0.0069 15.8 0.1 3.8 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain HEAT PF02985.22 KOO35268.1 - 2.2e-07 30.6 5.5 0.036 14.3 0.0 5.3 4 0 0 4 4 4 2 HEAT repeat RsgA_GTPase PF03193.16 KOO35268.1 - 1e-06 28.8 0.0 0.0076 16.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KOO35268.1 - 1.2e-05 25.0 0.2 0.12 12.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.6 KOO35268.1 - 3.1e-05 24.3 0.2 0.018 15.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 KOO35268.1 - 5.8e-05 23.1 0.0 0.047 13.8 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 KOO35268.1 - 8e-05 22.6 0.3 0.32 10.9 0.0 3.2 4 0 0 4 4 2 2 NACHT domain HEAT_EZ PF13513.6 KOO35268.1 - 9.7e-05 22.8 12.6 0.011 16.3 0.5 5.6 5 0 0 5 5 5 2 HEAT-like repeat AAA_22 PF13401.6 KOO35268.1 - 0.0004 20.7 0.2 0.18 12.0 0.1 3.7 3 1 0 3 3 3 1 AAA domain Roc PF08477.13 KOO35268.1 - 0.00049 20.3 0.1 0.029 14.6 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 KOO35268.1 - 0.00051 20.6 0.6 1.3 9.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOO35268.1 - 0.00087 19.7 1.2 0.97 9.8 0.0 4.0 3 1 0 3 3 3 1 AAA ATPase domain AAA_17 PF13207.6 KOO35268.1 - 0.002 18.5 0.1 0.38 11.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 KOO35268.1 - 0.0024 17.5 0.4 1.9 8.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 KOO35268.1 - 0.0035 17.1 0.7 2.4 7.8 0.1 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 KOO35268.1 - 0.0037 17.0 0.1 1.7 8.3 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 KOO35268.1 - 0.0043 17.2 0.0 3.9 7.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain CLASP_N PF12348.8 KOO35268.1 - 0.0075 15.9 0.0 0.16 11.5 0.0 2.7 3 0 0 3 3 3 1 CLASP N terminal RNA_helicase PF00910.22 KOO35268.1 - 0.0094 16.3 0.0 8.2 6.9 0.0 2.6 2 0 0 2 2 2 0 RNA helicase SbcCD_C PF13558.6 KOO35268.1 - 0.01 16.0 0.0 1.1 9.5 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 KOO35268.1 - 0.015 15.0 0.1 4.2 7.0 0.0 3.4 3 0 0 3 3 3 0 AAA domain Arm PF00514.23 KOO35268.1 - 0.034 14.2 1.4 84 3.4 0.0 5.0 5 0 0 5 5 4 0 Armadillo/beta-catenin-like repeat AAA_18 PF13238.6 KOO35268.1 - 0.035 14.6 0.0 5.2 7.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain MMS19_C PF12460.8 KOO35268.1 - 0.036 13.2 0.4 0.43 9.7 0.0 2.7 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal Dynamin_N PF00350.23 KOO35268.1 - 0.044 13.8 0.0 11 6.0 0.0 2.4 2 0 0 2 2 2 0 Dynamin family AAA_14 PF13173.6 KOO35268.1 - 0.047 13.7 0.0 4.2 7.4 0.0 3.1 3 0 0 3 3 2 0 AAA domain ATP-synt_ab PF00006.25 KOO35268.1 - 0.06 13.0 0.1 4.9 6.7 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.15 KOO35268.1 - 0.065 13.1 0.0 9.6 6.1 0.0 3.2 3 0 0 3 3 3 0 NTPase SRP54 PF00448.22 KOO35268.1 - 0.083 12.5 2.7 1.6 8.3 0.2 3.3 4 0 0 4 4 3 0 SRP54-type protein, GTPase domain AAA PF00004.29 KOO35268.1 - 0.091 13.2 0.0 5.5 7.4 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Arf PF00025.21 KOO35268.1 - 0.2 11.1 0.2 10 5.5 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family Septin PF00735.18 KOO35268.1 - 0.21 10.8 0.0 1.5 8.1 0.0 2.0 2 0 0 2 2 2 0 Septin TsaE PF02367.17 KOO35268.1 - 0.75 9.8 3.6 10 6.1 0.0 2.9 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Abhydrolase_1 PF00561.20 KOO35269.1 - 3.7e-17 62.8 0.0 3.5e-09 36.7 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOO35269.1 - 2e-13 51.4 1.5 2e-13 51.4 1.5 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO35269.1 - 5.9e-13 48.6 0.0 3e-08 33.2 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 KOO35269.1 - 0.00011 22.0 0.0 0.19 11.5 0.0 2.4 2 0 0 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOO35269.1 - 0.00028 20.4 0.0 0.0033 16.9 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Ndr PF03096.14 KOO35269.1 - 0.0047 15.7 0.0 0.23 10.1 0.0 2.1 2 0 0 2 2 2 1 Ndr family UPF0227 PF05728.12 KOO35269.1 - 0.057 13.4 0.0 4.7 7.1 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0227) PhoPQ_related PF10142.9 KOO35269.1 - 0.17 10.5 0.0 0.25 10.0 0.0 1.1 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein SAM_1 PF00536.30 KOO35270.1 - 1.2e-06 28.8 0.0 2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO35270.1 - 3.2e-06 27.2 0.0 5e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DEC-1_N PF04625.13 KOO35270.1 - 0.7 8.8 5.5 1.1 8.1 5.5 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF3682 PF12446.8 KOO35271.1 - 5.1 7.6 8.4 0.31 11.5 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) DUF441 PF04284.13 KOO35272.1 - 0.057 13.4 4.4 1 9.3 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF441) Glyco_transf_34 PF05637.12 KOO35272.1 - 0.1 12.3 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family FliX PF10768.9 KOO35274.1 - 0.0021 18.6 1.9 0.0075 16.8 1.9 1.9 1 0 0 1 1 1 1 Class II flagellar assembly regulator Nop14 PF04147.12 KOO35274.1 - 0.0076 14.5 3.8 0.011 14.0 3.8 1.1 1 0 0 1 1 1 1 Nop14-like family RPN2_C PF18004.1 KOO35274.1 - 0.037 13.9 1.7 0.088 12.7 1.7 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Merozoite_SPAM PF07133.11 KOO35274.1 - 0.35 10.8 10.5 0.68 9.9 10.5 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) PPP4R2 PF09184.11 KOO35274.1 - 3.4 7.2 8.1 5.4 6.5 8.1 1.2 1 0 0 1 1 1 0 PPP4R2 SNF2_N PF00176.23 KOO35275.1 - 1.1e-35 123.0 0.4 5.2e-35 120.8 0.4 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 KOO35275.1 - 3.4e-09 36.7 0.0 6.7e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO35275.1 - 2.6e-08 34.2 0.0 1e-06 29.0 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO35275.1 - 1.7e-05 24.9 0.0 4.4e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Agenet PF05641.12 KOO35275.1 - 0.1 13.1 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 Agenet domain LRR_9 PF14580.6 KOO35275.1 - 0.12 11.8 0.0 2 7.9 0.0 2.3 2 0 0 2 2 2 0 Leucine-rich repeat Polyketide_cyc2 PF10604.9 KOO35276.1 - 7.8e-05 23.0 2.1 0.00014 22.1 0.1 2.3 2 0 0 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Aldedh PF00171.22 KOO35277.1 - 2.9e-79 266.8 0.0 3.2e-79 266.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family bact-PGI_C PF10432.9 KOO35277.1 - 0.039 14.0 0.0 0.085 12.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal SIS domain APH PF01636.23 KOO35278.1 - 2.1e-20 73.7 0.0 2.9e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOO35278.1 - 2.3e-07 30.6 0.0 4.2e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase LRR_6 PF13516.6 KOO35279.1 - 3.6e-14 51.5 5.8 0.00033 20.5 0.0 5.7 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 KOO35279.1 - 0.034 14.7 0.4 12 7.0 0.0 4.0 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_5 PF13306.6 KOO35280.1 - 1.4e-98 325.7 0.0 5.1e-37 126.7 0.1 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO35280.1 - 1.2e-21 76.2 0.0 0.00058 19.6 0.0 6.9 1 1 7 8 8 8 8 Leucine rich repeat Forkhead_N PF08430.12 KOO35280.1 - 0.0038 17.8 4.6 5.7 7.5 2.5 3.2 1 1 1 2 2 2 2 Forkhead N-terminal region NADHdh PF00146.21 KOO35280.1 - 0.68 9.2 5.7 5.8 6.1 0.2 3.5 2 2 3 5 5 5 0 NADH dehydrogenase DUF1068 PF06364.12 KOO35280.1 - 1.1 9.1 3.2 6.5 6.6 0.1 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1068) PhyH PF05721.13 KOO35281.1 - 0.0039 17.5 0.1 0.0089 16.3 0.1 1.5 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) IQ PF00612.27 KOO35281.1 - 0.015 15.0 3.6 0.058 13.2 3.6 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif Mitoc_L55 PF09776.9 KOO35282.1 - 1.3e-07 31.4 0.1 0.77 9.5 0.0 5.5 1 1 4 6 6 6 4 Mitochondrial ribosomal protein L55 RNase_T PF00929.24 KOO35283.1 - 6.8e-21 75.5 0.0 1e-20 74.9 0.0 1.3 1 0 0 1 1 1 1 Exonuclease RNase_H_2 PF13482.6 KOO35283.1 - 0.044 13.8 0.0 11 5.9 0.0 2.2 2 0 0 2 2 2 0 RNase_H superfamily tRNA-synt_1 PF00133.22 KOO35285.1 - 1.5e-218 727.0 0.0 1.9e-218 726.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KOO35285.1 - 1.2e-23 83.8 0.1 2.7e-23 82.6 0.0 1.7 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KOO35285.1 - 2e-15 56.5 0.1 7.8e-06 24.9 0.0 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 KOO35285.1 - 0.00075 18.9 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Kelch_3 PF13415.6 KOO35286.1 - 1.5e-11 44.3 3.7 0.00038 20.7 0.1 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO35286.1 - 3.2e-05 23.8 1.1 0.085 12.9 0.0 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 KOO35286.1 - 4.1e-05 23.5 6.7 0.0045 17.0 0.0 5.1 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_2 PF07646.15 KOO35286.1 - 0.22 11.6 5.6 3 8.0 0.0 4.1 5 0 0 5 5 5 0 Kelch motif Pkinase PF00069.25 KOO35287.1 - 0.27 10.5 0.3 4.3 6.6 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain VPS13_C PF16909.5 KOO35289.1 - 2.2e-08 34.1 0.0 3.2e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal EF-hand_1 PF00036.32 KOO35292.1 - 2.3e-10 39.3 0.7 0.00042 19.7 0.2 2.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO35292.1 - 7.2e-10 39.2 0.0 1.2e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO35292.1 - 4.8e-09 35.4 0.7 0.00069 19.3 0.2 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO35292.1 - 1.4e-08 34.4 0.1 0.0036 17.1 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO35292.1 - 8.1e-08 31.4 1.3 0.0091 15.5 0.3 3.3 3 0 0 3 3 3 2 EF hand Ank PF00023.30 KOO35293.1 - 1e-06 28.9 0.0 0.0054 17.1 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 KOO35293.1 - 9.7e-05 22.9 0.0 0.00068 20.2 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO35293.1 - 0.00039 20.7 0.2 2 8.8 0.0 3.2 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO35293.1 - 0.00093 19.7 0.0 0.078 13.6 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Beta_helix PF13229.6 KOO35294.1 - 1.1e-09 38.4 13.7 3.7e-08 33.4 12.5 2.5 1 1 0 1 1 1 1 Right handed beta helix region Adeno_E1B_55K PF01696.17 KOO35294.1 - 0.26 9.9 0.3 0.37 9.4 0.3 1.1 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen Aa_trans PF01490.18 KOO35295.1 - 2e-18 66.3 11.9 3e-18 65.7 11.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EF-hand_1 PF00036.32 KOO35296.1 - 2.1e-20 70.7 5.3 1.4e-05 24.3 0.5 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO35296.1 - 1.3e-19 70.4 3.3 6e-09 36.2 1.1 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO35296.1 - 1e-17 62.5 2.7 0.00078 19.2 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO35296.1 - 1.6e-12 46.3 3.1 0.0018 17.7 0.2 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO35296.1 - 8e-09 35.2 6.1 0.002 17.9 1.4 3.8 2 2 2 4 4 4 2 EF-hand domain pair LRR_6 PF13516.6 KOO35296.1 - 4.7e-06 26.2 1.9 0.00051 19.9 0.0 3.4 3 0 0 3 3 3 1 Leucine Rich repeat LRR_8 PF13855.6 KOO35296.1 - 3.1e-05 23.7 1.3 0.021 14.6 0.1 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KOO35296.1 - 0.00028 21.2 0.1 0.16 12.4 0.0 2.8 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) EF-hand_4 PF12763.7 KOO35296.1 - 0.04 13.9 0.1 5.9 6.9 0.0 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand LRR_1 PF00560.33 KOO35296.1 - 0.16 12.6 2.5 1.2e+02 3.9 0.3 4.3 4 1 0 4 4 4 0 Leucine Rich Repeat EF-hand_10 PF14788.6 KOO35296.1 - 0.29 11.0 3.8 12 5.8 0.1 3.2 3 0 0 3 3 3 0 EF hand DUF2009 PF09418.10 KOO35297.1 - 4.4e-34 118.3 2.1 4.7e-34 118.2 2.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) TPP_enzyme_N PF02776.18 KOO35299.1 - 6.2e-56 188.7 0.0 1.6e-55 187.4 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOO35299.1 - 1.5e-41 141.4 0.1 2.8e-41 140.5 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 KOO35299.1 - 1.8e-40 138.3 0.1 5.8e-40 136.6 0.0 2.0 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Glyco_transf_4 PF13439.6 KOO35299.1 - 0.017 15.1 0.2 0.043 13.8 0.2 1.6 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Bmp PF02608.14 KOO35299.1 - 0.041 12.9 0.0 0.9 8.5 0.0 2.6 3 0 0 3 3 3 0 ABC transporter substrate-binding protein PnrA-like ABATE PF07336.11 KOO35299.1 - 0.15 12.7 1.4 0.33 11.6 1.4 1.6 1 0 0 1 1 1 0 Putative stress-induced transcription regulator SNF2_N PF00176.23 KOO35301.1 - 1e-54 185.6 0.0 1.6e-54 184.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 KOO35301.1 - 1.5e-18 66.4 0.1 3.6e-10 39.6 0.0 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 KOO35301.1 - 2.6e-16 59.9 0.0 6.4e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO35301.1 - 1e-07 32.1 0.0 2e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO35301.1 - 5.1e-05 23.1 0.0 0.00012 21.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 KOO35301.1 - 0.00025 21.2 0.0 0.15 12.2 0.0 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain MORN PF02493.20 KOO35302.1 - 9.4e-11 41.0 31.7 0.00034 20.3 2.1 6.3 6 0 0 6 6 6 5 MORN repeat DUF4638 PF15472.6 KOO35302.1 - 0.21 11.3 6.9 1.1 8.9 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) PATR PF12951.7 KOO35302.1 - 0.22 11.7 2.9 7.7 6.7 0.9 2.3 2 0 0 2 2 2 0 Passenger-associated-transport-repeat SET PF00856.28 KOO35303.1 - 1.5e-05 25.5 0.0 0.0007 20.0 0.0 2.6 2 1 0 2 2 2 1 SET domain LRR_6 PF13516.6 KOO35304.1 - 1e-22 78.2 31.6 0.0018 18.2 0.2 10.3 11 0 0 11 11 11 8 Leucine Rich repeat LRR_1 PF00560.33 KOO35304.1 - 7.2e-09 35.0 3.3 2.9 8.8 0.4 7.8 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO35304.1 - 2.4e-08 33.6 11.1 3.9 7.3 0.1 8.1 7 2 0 7 7 7 4 Leucine rich repeat LRR_4 PF12799.7 KOO35304.1 - 2.8e-08 33.9 15.4 3.3 8.3 0.0 6.9 6 1 0 6 6 6 4 Leucine Rich repeats (2 copies) CENP-B_dimeris PF09026.10 KOO35304.1 - 0.45 10.9 11.8 0.96 9.9 11.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 KOO35304.1 - 8.6 5.6 9.8 7.2 5.8 8.2 1.6 2 0 0 2 2 2 0 NOA36 protein Agenet PF05641.12 KOO35308.1 - 1.3e-15 57.6 6.0 2.2e-09 37.6 1.1 2.7 2 0 0 2 2 2 2 Agenet domain Chromo PF00385.24 KOO35308.1 - 1.3e-06 28.2 0.8 1.1e-05 25.2 0.0 2.6 2 1 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain EF-hand_1 PF00036.32 KOO35309.1 - 2.5e-12 45.4 0.1 0.00032 20.0 0.0 4.8 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 KOO35309.1 - 2.3e-07 30.2 0.0 0.029 14.3 0.0 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KOO35309.1 - 3.2e-06 26.4 4.1 0.14 11.7 0.1 4.5 4 0 0 4 4 4 2 EF hand Tli4_C PF18426.1 KOO35309.1 - 0.00015 22.1 1.7 0.11 12.8 0.0 2.9 3 1 0 3 3 3 2 Tle cognate immunity protein 4 C-terminal domain EF-hand_7 PF13499.6 KOO35309.1 - 0.0039 17.6 0.0 2.4 8.6 0.0 3.8 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO35309.1 - 0.012 15.4 0.0 11 5.9 0.0 4.1 4 0 0 4 4 4 0 EF-hand domain pair TUDOR_5 PF18359.1 KOO35309.1 - 0.092 12.5 2.8 3.9 7.2 0.0 2.8 3 0 0 3 3 3 0 Histone methyltransferase Tudor domain 1 VWA_2 PF13519.6 KOO35312.1 - 0.00016 22.3 0.0 0.00069 20.2 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain DNA_pol3_delta2 PF13177.6 KOO35314.1 - 2e-08 34.2 0.0 1.6e-07 31.2 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 KOO35314.1 - 2.3e-05 24.4 0.0 3.8e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain Rep_fac_C PF08542.11 KOO35314.1 - 0.00022 21.5 0.0 0.0006 20.2 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_16 PF13191.6 KOO35314.1 - 0.00028 21.3 0.1 0.00088 19.7 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 KOO35314.1 - 0.0049 17.3 0.0 0.012 16.1 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOO35314.1 - 0.03 14.1 0.0 3.5 7.3 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Retinin_C PF04527.12 KOO35314.1 - 0.031 14.5 0.3 1.2 9.5 0.0 2.6 2 0 0 2 2 2 0 Drosophila Retinin like protein DNA_pol3_delta PF06144.13 KOO35314.1 - 0.035 13.9 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_22 PF13401.6 KOO35314.1 - 0.068 13.4 0.0 0.23 11.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KOO35314.1 - 0.073 13.1 0.1 0.27 11.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 KOO35314.1 - 0.11 12.3 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain T4SS-DNA_transf PF02534.14 KOO35314.1 - 0.15 10.9 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer AAA_24 PF13479.6 KOO35314.1 - 0.18 11.5 0.0 0.63 9.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOO35314.1 - 0.21 12.1 0.0 0.33 11.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 KOO35314.1 - 0.23 11.2 0.0 0.61 9.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Bestrophin PF01062.21 KOO35316.1 - 3.2e-14 53.0 0.4 3.8e-14 52.8 0.4 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel LRR_6 PF13516.6 KOO35317.1 - 4.5e-10 38.7 0.3 0.029 14.4 0.1 4.2 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 KOO35317.1 - 0.05 14.0 0.3 6.9 7.2 0.0 3.5 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) U-box PF04564.15 KOO35318.1 - 2.9e-11 43.4 0.0 5.6e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 KOO35318.1 - 8.4e-05 22.6 0.0 0.00017 21.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO35318.1 - 0.018 14.9 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Polysacc_deac_1 PF01522.21 KOO35319.1 - 4.8e-17 62.0 0.0 7.2e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase AroM PF07302.11 KOO35320.1 - 7.5e-08 32.0 0.0 1.6e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 AroM protein TauD PF02668.16 KOO35320.1 - 0.0052 16.6 0.0 0.0072 16.1 0.0 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PTPRCAP PF15713.5 KOO35321.1 - 0.013 15.8 1.1 0.019 15.2 1.1 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated UVR PF02151.19 KOO35321.1 - 1.2 9.0 4.6 0.67 9.8 0.3 2.6 2 0 0 2 2 2 0 UvrB/uvrC motif Bacteriocin_IIc PF10439.9 KOO35322.1 - 0.0016 18.5 2.4 0.0027 17.8 2.4 1.3 1 0 0 1 1 1 1 Bacteriocin class II with double-glycine leader peptide DUF456 PF04306.13 KOO35322.1 - 0.058 13.7 8.0 0.15 12.3 8.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF456) Gly-zipper_YMGG PF13441.6 KOO35322.1 - 0.17 11.7 7.3 0.3 10.8 7.3 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper Phage_holin_8 PF16931.5 KOO35322.1 - 0.67 9.9 7.7 0.35 10.8 5.2 1.8 1 1 1 2 2 2 0 Putative phage holin Gly-zipper_OmpA PF13436.6 KOO35322.1 - 0.96 9.3 9.3 2.3 8.1 9.3 1.6 1 1 0 1 1 1 0 Glycine-zipper domain Rick_17kDa_Anti PF05433.15 KOO35322.1 - 7.5 6.5 13.5 49 3.9 13.5 2.1 1 1 0 1 1 1 0 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 KOO35322.1 - 8.4 6.5 12.8 90 3.2 12.8 2.1 1 1 0 1 1 1 0 Glycine zipper Mucin15 PF15672.5 KOO35322.1 - 10 5.5 7.9 13 5.1 6.6 1.8 1 1 0 1 1 1 0 Cell-membrane associated Mucin15 START PF01852.19 KOO35324.1 - 5.2e-19 68.5 0.0 1.2e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 START domain 4HBT PF03061.22 KOO35324.1 - 7e-17 61.6 6.1 1e-08 35.4 1.6 2.9 2 0 0 2 2 2 2 Thioesterase superfamily EF-hand_4 PF12763.7 KOO35324.1 - 1.1e-09 38.2 0.0 2.1e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand MoaC PF01967.21 KOO35324.1 - 0.069 13.2 2.0 0.14 12.2 0.4 2.1 2 0 0 2 2 2 0 MoaC family EF-hand_8 PF13833.6 KOO35324.1 - 0.12 12.2 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 KOO35324.1 - 0.18 11.4 0.0 0.37 10.4 0.0 1.5 1 0 0 1 1 1 0 EF hand Pkinase PF00069.25 KOO35325.1 - 3.1e-50 171.0 0.0 4e-50 170.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35325.1 - 3.5e-17 62.6 0.0 6.1e-17 61.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO35325.1 - 1.4e-08 34.5 0.0 7.5e-06 25.5 0.0 2.6 2 1 0 2 2 2 2 Kinase-like APH PF01636.23 KOO35325.1 - 2.4e-05 24.4 0.6 0.00019 21.4 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO35325.1 - 5.7e-05 22.1 0.0 8.7e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOO35325.1 - 0.0054 16.1 0.0 0.0092 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KOO35325.1 - 0.0085 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 KOO35325.1 - 0.01 15.4 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.11 KOO35325.1 - 0.088 11.8 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FAD_binding_3 PF01494.19 KOO35326.1 - 3e-06 26.7 0.5 5.6e-06 25.8 0.5 1.4 1 0 0 1 1 1 1 FAD binding domain EF-hand_5 PF13202.6 KOO35326.1 - 0.023 14.2 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 EF hand GLE1 PF07817.13 KOO35327.1 - 2.3e-34 118.8 0.1 3.4e-34 118.2 0.1 1.3 1 0 0 1 1 1 1 GLE1-like protein DUF3342 PF11822.8 KOO35330.1 - 1.5e-19 69.9 0.0 2.7e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB PF00651.31 KOO35330.1 - 0.00029 21.0 0.0 0.00051 20.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain RT_RNaseH_2 PF17919.1 KOO35330.1 - 0.092 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase EF-hand_1 PF00036.32 KOO35331.1 - 2e-19 67.6 8.9 4.2e-06 25.9 0.5 4.1 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 KOO35331.1 - 5.2e-19 66.8 4.5 6.8e-07 28.5 0.3 3.8 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO35331.1 - 3.7e-18 65.7 1.8 3.3e-12 46.7 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO35331.1 - 1.7e-16 58.7 5.5 5.1e-06 26.0 0.1 4.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 KOO35331.1 - 7.6e-15 54.5 7.1 3.4e-08 33.2 0.7 3.3 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO35331.1 - 1.4e-06 28.6 4.3 8.4e-06 26.1 0.0 2.7 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO35331.1 - 0.0032 17.4 0.8 0.071 13.1 0.2 2.6 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand PAN_1 PF00024.26 KOO35331.1 - 0.019 15.0 2.4 0.032 14.2 2.4 1.3 1 0 0 1 1 1 0 PAN domain Dockerin_1 PF00404.18 KOO35331.1 - 0.15 12.3 0.1 12 6.1 0.0 2.8 2 0 0 2 2 2 0 Dockerin type I domain Excalibur PF05901.11 KOO35331.1 - 0.83 10.3 3.9 53 4.6 2.1 3.3 2 1 0 2 2 2 0 Excalibur calcium-binding domain TTL PF03133.15 KOO35333.1 - 3.9e-31 108.3 0.0 4.9e-31 108.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO35333.1 - 0.0009 18.6 0.0 1.3 8.2 0.0 2.7 2 1 0 2 2 2 2 YheC/D like ATP-grasp Dala_Dala_lig_C PF07478.13 KOO35333.1 - 0.26 10.8 0.0 0.55 9.7 0.0 1.5 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Toxin_14 PF07829.11 KOO35334.1 - 0.47 10.4 7.8 0.08 12.9 3.4 2.1 2 0 0 2 2 2 0 Alpha-A conotoxin PIVA-like protein LRR_5 PF13306.6 KOO35335.1 - 2.5e-114 376.6 3.6 1.6e-43 147.7 0.1 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO35335.1 - 2.3e-17 62.5 0.0 0.0074 16.0 0.0 6.9 2 1 8 10 10 10 9 Leucine rich repeat Peptidase_M8 PF01457.16 KOO35335.1 - 0.004 15.9 3.4 12 4.5 0.0 4.1 1 1 3 4 4 4 2 Leishmanolysin PilA4 PF18682.1 KOO35335.1 - 0.0074 16.6 18.4 17 5.9 0.0 8.4 1 1 10 11 11 11 1 Pilin A4 HTH_39 PF14090.6 KOO35335.1 - 0.26 11.0 1.1 89 2.9 0.0 4.5 4 2 1 6 6 6 0 Helix-turn-helix domain EF-hand_6 PF13405.6 KOO35337.1 - 1.6e-18 64.9 0.5 8.7e-05 22.2 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO35337.1 - 4.9e-18 65.4 0.0 5.4e-08 33.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO35337.1 - 4.3e-17 60.3 0.1 2.6e-05 23.4 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO35337.1 - 1.3e-12 46.6 0.1 0.0015 18.0 0.0 4.5 4 0 0 4 4 4 2 EF hand GPS PF01825.21 KOO35337.1 - 2.9e-09 37.3 6.4 6.3e-09 36.2 6.4 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EF-hand_8 PF13833.6 KOO35337.1 - 0.0023 17.7 0.0 2.2 8.2 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO35337.1 - 0.011 16.0 0.0 8.1 6.9 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO35337.1 - 0.012 16.0 0.0 0.27 11.6 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region SAP PF02037.27 KOO35337.1 - 0.23 11.3 0.4 33 4.4 0.1 2.6 2 0 0 2 2 2 0 SAP domain Antimicrobial13 PF08108.11 KOO35337.1 - 7.1 6.9 9.4 24 5.2 1.4 2.9 2 0 0 2 2 2 0 Halocidin family LRR_4 PF12799.7 KOO35338.1 - 7e-14 51.7 42.2 0.017 15.6 0.5 9.6 9 1 1 10 10 10 6 Leucine Rich repeats (2 copies) Roc PF08477.13 KOO35338.1 - 7.2e-10 39.1 0.0 1.8e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 KOO35338.1 - 2.8e-09 36.6 38.2 0.00088 19.0 0.2 9.3 5 3 2 8 8 8 5 Leucine rich repeat Arf PF00025.21 KOO35338.1 - 0.0003 20.3 0.0 0.00066 19.2 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family LRR_6 PF13516.6 KOO35338.1 - 0.00048 20.0 0.1 0.00048 20.0 0.1 13.5 16 0 0 16 16 16 3 Leucine Rich repeat Ras PF00071.22 KOO35338.1 - 0.0012 18.5 0.0 0.0036 16.9 0.0 1.8 2 0 0 2 2 2 1 Ras family LRR_1 PF00560.33 KOO35338.1 - 0.029 14.9 26.9 27 5.8 0.1 10.9 13 0 0 13 13 13 0 Leucine Rich Repeat MMR_HSR1 PF01926.23 KOO35338.1 - 0.14 12.3 0.0 0.39 10.8 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 KOO35338.1 - 0.2 11.6 0.8 4.6 7.1 0.0 3.3 4 0 0 4 4 4 0 NACHT domain NifU PF01106.17 KOO35339.1 - 3.9e-32 110.2 0.2 1.2e-22 79.9 0.1 2.3 2 0 0 2 2 2 2 NifU-like domain Cthe_2159 PF14262.6 KOO35339.1 - 0.13 11.6 0.0 0.38 10.1 0.0 1.7 2 0 0 2 2 2 0 Carbohydrate-binding domain-containing protein Cthe_2159 Aldo_ket_red PF00248.21 KOO35341.1 - 5.4e-44 150.6 0.0 8e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family MFAP1 PF06991.11 KOO35342.1 - 1.1e-57 195.4 21.4 1.1e-57 195.4 21.4 2.8 1 1 2 3 3 3 1 Microfibril-associated/Pre-mRNA processing Adeno_terminal PF02459.15 KOO35342.1 - 6.3 5.1 11.4 11 4.2 11.4 1.3 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Latarcin PF10279.9 KOO35345.1 - 0.017 15.5 0.2 0.035 14.5 0.2 1.6 1 0 0 1 1 1 0 Latarcin precursor DXP_reductoisom PF02670.16 KOO35345.1 - 0.068 13.9 0.3 0.15 12.8 0.2 1.5 1 1 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Hypoth_Ymh PF09509.10 KOO35345.1 - 0.077 12.9 0.4 3 7.8 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (Hypoth_ymh) DUF3322 PF11795.8 KOO35345.1 - 0.079 13.0 1.2 0.1 12.6 1.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) TFA2_Winged_2 PF18121.1 KOO35345.1 - 0.081 12.6 0.3 0.22 11.2 0.2 1.8 1 1 1 2 2 2 0 TFA2 Winged helix domain 2 PhyH PF05721.13 KOO35346.1 - 1.4e-13 51.6 0.0 1.6e-07 31.8 0.0 3.0 2 2 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) CRAL_TRIO PF00650.20 KOO35347.1 - 2.7e-16 59.7 0.0 3.1e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain EF-hand_1 PF00036.32 KOO35348.1 - 1e-40 134.2 10.1 2.9e-06 26.4 0.1 6.5 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.6 KOO35348.1 - 3.9e-33 111.5 7.8 0.0004 19.7 0.0 6.6 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO35348.1 - 7.2e-31 106.5 10.7 2.6e-09 37.4 0.1 4.5 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.6 KOO35348.1 - 2.5e-29 98.6 0.4 0.0003 20.5 0.0 6.5 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.6 KOO35348.1 - 3.6e-18 65.2 10.7 3.7e-05 23.5 0.1 6.2 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_9 PF14658.6 KOO35348.1 - 1.6e-12 47.5 0.9 0.00042 20.6 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO35348.1 - 2.7e-10 40.6 0.1 0.037 14.3 0.0 3.2 3 0 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO35348.1 - 1.9e-08 34.2 2.8 0.038 13.9 0.0 3.9 3 2 1 4 4 4 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO35348.1 - 9.9e-06 25.7 10.5 0.36 11.1 0.2 3.9 3 2 0 3 3 3 3 Dockerin type I domain TssD PF17642.1 KOO35348.1 - 8.9e-05 22.3 1.1 2 8.3 0.1 3.2 3 0 0 3 3 3 2 Hemolysin coregulated protein Hcp (TssD) SelB-wing_3 PF09107.11 KOO35348.1 - 0.0005 19.7 0.2 19 5.0 0.0 4.6 4 0 0 4 4 4 0 Elongation factor SelB, winged helix VbhA PF18495.1 KOO35348.1 - 0.0042 16.9 1.6 77 3.3 0.0 4.9 5 0 0 5 5 5 0 Antitoxin VbhA EF-hand_10 PF14788.6 KOO35348.1 - 0.023 14.6 0.2 19 5.2 0.0 4.5 6 0 0 6 6 6 0 EF hand HpaB_N PF11794.8 KOO35348.1 - 0.041 13.5 0.2 0.13 11.9 0.1 1.9 3 0 0 3 3 3 0 4-hydroxyphenylacetate 3-hydroxylase N terminal CEP19 PF14933.6 KOO35348.1 - 0.18 12.1 4.5 15 5.8 0.0 3.1 3 0 0 3 3 3 0 CEP19-like protein Ank_2 PF12796.7 KOO35349.1 - 1.8e-33 114.9 3.6 1.6e-13 51.0 0.3 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO35349.1 - 3.6e-19 66.8 1.4 6.9e-05 23.0 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 KOO35349.1 - 2e-18 66.5 0.5 5.5e-07 30.0 0.1 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO35349.1 - 2e-17 62.7 1.7 4.8e-05 23.6 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO35349.1 - 4.8e-16 58.6 1.9 7.4e-08 32.5 0.1 3.9 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Phospholip_A2_2 PF05826.12 KOO35349.1 - 0.059 13.6 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Phospholipase A2 EF-hand_7 PF13499.6 KOO35350.1 - 2.1e-31 108.2 4.0 9.7e-11 42.0 0.1 3.4 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO35350.1 - 4e-27 91.7 18.5 6.7e-05 22.2 0.1 6.4 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.6 KOO35350.1 - 1.8e-24 83.5 4.8 0.0028 17.5 0.0 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.6 KOO35350.1 - 1.9e-23 80.8 14.6 9.7e-05 21.7 0.1 6.5 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.6 KOO35350.1 - 1.8e-18 66.1 16.8 0.00079 19.2 0.1 6.2 4 2 2 6 6 6 5 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO35350.1 - 8.8e-06 26.0 0.1 3.6 7.9 0.0 4.1 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO35350.1 - 5.8e-05 23.3 0.6 0.0058 16.9 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain Dockerin_1 PF00404.18 KOO35350.1 - 0.025 14.8 6.2 4.4 7.6 0.5 4.0 3 2 0 3 3 3 0 Dockerin type I domain HJURP_C PF12347.8 KOO35350.1 - 0.033 14.2 0.2 0.94 9.6 0.1 2.3 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat DUF1153 PF06627.11 KOO35350.1 - 0.049 13.8 0.0 3.5 7.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1153) SHOCT PF09851.9 KOO35350.1 - 0.13 12.0 4.4 1.1 9.1 1.3 2.9 3 0 0 3 3 3 0 Short C-terminal domain HALZ PF02183.18 KOO35350.1 - 0.25 11.6 3.1 16 5.8 0.3 2.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper Arf PF00025.21 KOO35351.1 - 4.2e-54 182.6 0.0 4.8e-54 182.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KOO35351.1 - 5e-13 48.9 1.4 2.7e-08 33.4 0.2 2.6 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KOO35351.1 - 9.9e-12 44.8 0.0 1.1e-11 44.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO35351.1 - 1e-10 41.8 0.0 1.4e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KOO35351.1 - 1.3e-09 37.7 0.0 1.8e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KOO35351.1 - 8e-06 25.9 0.0 1.2e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOO35351.1 - 0.00013 21.4 0.0 0.00017 21.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOO35351.1 - 0.00018 21.1 0.0 0.004 16.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain 6PF2K PF01591.18 KOO35351.1 - 0.025 13.9 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase RsgA_GTPase PF03193.16 KOO35351.1 - 0.13 12.1 0.1 16 5.3 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase FeoB_N PF02421.18 KOO35351.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.5 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 KOO35351.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RRM_1 PF00076.22 KOO35352.1 - 1.6e-13 50.3 0.0 2.5e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MatE PF01554.18 KOO35353.1 - 5.4e-05 22.9 6.3 5.4e-05 22.9 6.3 2.4 1 1 1 2 2 2 1 MatE MENTAL PF10457.9 KOO35353.1 - 0.07 12.9 3.4 0.17 11.7 0.2 2.2 2 0 0 2 2 2 0 Cholesterol-capturing domain DUF1774 PF08611.10 KOO35353.1 - 0.17 12.2 0.2 0.17 12.2 0.2 2.6 3 1 1 4 4 4 0 Fungal protein of unknown function (DUF1774) Neurensin PF14927.6 KOO35353.1 - 0.22 11.2 2.3 0.25 11.1 0.5 2.2 1 1 0 1 1 1 0 Neurensin Patatin PF01734.22 KOO35354.1 - 4.9e-12 46.5 1.4 1.7e-11 44.7 1.4 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase Pkinase PF00069.25 KOO35355.1 - 4.5e-44 150.8 0.1 6.5e-44 150.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35355.1 - 1.2e-21 77.1 0.3 2.1e-21 76.4 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO35355.1 - 0.0034 17.4 0.0 0.0034 17.4 0.0 2.1 3 0 0 3 3 3 1 Phosphotransferase enzyme family DnaJ PF00226.31 KOO35356.1 - 6.8e-12 45.3 0.0 1.4e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Tetraspanin PF00335.20 KOO35356.1 - 5.8e-09 36.0 18.7 5.9e-09 36.0 6.1 2.5 2 1 0 2 2 2 2 Tetraspanin family Dynamin_N PF00350.23 KOO35358.1 - 5.5e-11 42.8 0.0 1.1e-05 25.6 0.0 2.3 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.23 KOO35358.1 - 9.6e-05 22.4 0.0 0.00053 20.1 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase YpsA PF06908.11 KOO35358.1 - 0.035 14.1 0.0 0.059 13.4 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family AIG1 PF04548.16 KOO35358.1 - 0.056 12.8 0.0 0.7 9.2 0.1 2.2 2 0 0 2 2 2 0 AIG1 family RsgA_GTPase PF03193.16 KOO35358.1 - 0.12 12.3 0.0 4.3 7.2 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase DUF815 PF05673.13 KOO35358.1 - 0.15 11.2 0.0 0.26 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SDH_sah PF01972.16 KOO35358.1 - 0.35 9.8 0.8 0.55 9.2 0.8 1.2 1 0 0 1 1 1 0 Serine dehydrogenase proteinase AAA PF00004.29 KOO35359.1 - 1.4e-09 38.4 0.0 3.3e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_assoc_2 PF16193.5 KOO35359.1 - 0.0012 19.1 0.1 0.0048 17.2 0.1 2.1 1 0 0 1 1 1 1 AAA C-terminal domain AAA_14 PF13173.6 KOO35359.1 - 0.019 15.0 0.0 0.039 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF5316 PF17247.2 KOO35360.1 - 0.019 14.9 2.6 0.076 13.0 0.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5316) PepSY_TM PF03929.16 KOO35360.1 - 0.031 13.9 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM region NAD_binding_8 PF13450.6 KOO35361.1 - 2.7e-13 49.9 0.0 9.1e-13 48.2 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOO35361.1 - 1.5e-07 31.4 0.7 2.6e-07 30.5 0.7 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 KOO35361.1 - 4.5e-07 29.5 0.0 2.6e-06 27.0 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 KOO35361.1 - 0.0009 18.6 0.0 0.0088 15.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOO35361.1 - 0.0013 18.0 0.1 0.0031 16.8 0.1 1.5 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 KOO35361.1 - 0.0026 16.9 0.1 0.0042 16.2 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 KOO35361.1 - 0.015 14.6 0.1 0.025 13.8 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 KOO35361.1 - 0.03 14.3 0.4 0.54 10.2 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 KOO35361.1 - 0.093 13.3 0.2 0.2 12.2 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOO35361.1 - 0.17 11.2 0.0 0.38 10.0 0.0 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RCC1 PF00415.18 KOO35362.1 - 7.9e-150 487.4 29.7 2.6e-14 53.6 0.5 14.4 14 0 0 14 14 14 13 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO35362.1 - 1.5e-73 241.4 68.2 5.8e-08 32.3 0.1 13.5 13 0 0 13 13 13 13 Regulator of chromosome condensation (RCC1) repeat RasGAP PF00616.19 KOO35362.1 - 5.4e-39 134.1 0.0 1.4e-38 132.7 0.0 1.7 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Hira PF07569.11 KOO35362.1 - 1e-05 25.4 0.1 16 5.1 0.0 6.1 6 0 0 6 6 6 1 TUP1-like enhancer of split DNA_pol_A_exo1 PF01612.20 KOO35363.1 - 1.3e-05 25.0 0.0 0.00019 21.2 0.0 2.3 2 0 0 2 2 2 1 3'-5' exonuclease Frigida PF07899.11 KOO35363.1 - 0.043 13.1 0.7 0.13 11.5 0.1 2.0 2 1 0 2 2 2 0 Frigida-like protein Lzipper-MIP1 PF14389.6 KOO35363.1 - 0.051 13.9 0.3 0.25 11.7 0.2 2.2 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 UTP15_C PF09384.10 KOO35363.1 - 3.6 7.3 5.5 0.52 10.0 0.4 2.2 3 0 0 3 3 3 0 UTP15 C terminal Ank_2 PF12796.7 KOO35364.1 - 1.3e-19 70.5 7.0 2.4e-07 31.2 0.3 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 KOO35364.1 - 3.5e-13 49.3 4.9 0.0014 19.0 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOO35364.1 - 5.4e-13 48.9 6.7 4e-06 27.0 0.1 4.9 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO35364.1 - 1.5e-12 47.8 0.4 3.7e-06 27.4 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35364.1 - 3.7e-12 45.3 1.3 0.0051 17.2 0.0 4.9 4 0 0 4 4 4 3 Ankyrin repeat DUF1843 PF08898.10 KOO35364.1 - 0.21 12.1 8.2 6.6 7.3 0.1 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF1843) Glyco_transf_5 PF08323.11 KOO35365.1 - 3.9e-22 79.1 0.0 7.1e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 KOO35365.1 - 8.2e-13 48.3 0.0 2.9e-12 46.4 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOO35365.1 - 2.3e-09 37.8 0.0 1.2e-08 35.4 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Galactosyl_T PF01762.21 KOO35365.1 - 2.2e-06 27.6 0.0 5e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 Galactosyltransferase Redoxin PF08534.10 KOO35367.1 - 2.6e-09 36.9 0.0 3.1e-09 36.7 0.0 1.0 1 0 0 1 1 1 1 Redoxin Aminotran_3 PF00202.21 KOO35368.1 - 7.1e-72 242.3 0.0 1.6e-71 241.1 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-III ATF7IP_BD PF16788.5 KOO35368.1 - 0.38 10.8 3.3 1.5 8.9 0.5 2.1 2 0 0 2 2 2 0 ATF-interacting protein binding domain Cep57_MT_bd PF06657.13 KOO35368.1 - 9.9 6.7 13.2 19 5.8 1.3 2.5 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 LRR_6 PF13516.6 KOO35369.1 - 2.5e-19 67.6 48.7 0.0082 16.1 0.1 15.4 16 0 0 16 16 16 7 Leucine Rich repeat Ank_2 PF12796.7 KOO35369.1 - 5.1e-11 43.0 4.4 0.00053 20.5 1.7 4.4 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO35369.1 - 1.1e-07 31.6 2.8 1.1 10.1 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat LRR_8 PF13855.6 KOO35369.1 - 3e-07 30.1 8.8 5.6 6.8 0.4 8.9 10 1 1 11 11 11 2 Leucine rich repeat LRR_1 PF00560.33 KOO35369.1 - 4e-07 29.7 6.6 31 5.7 0.0 10.0 12 0 0 12 12 10 0 Leucine Rich Repeat SPRY PF00622.28 KOO35369.1 - 2.7e-05 24.3 0.0 5.2e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 SPRY domain Ank_4 PF13637.6 KOO35369.1 - 0.0001 22.8 4.2 0.89 10.2 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeats (many copies) GlutR_N PF05201.15 KOO35369.1 - 0.054 13.2 0.3 21 4.9 0.0 3.6 4 0 0 4 4 4 0 Glutamyl-tRNAGlu reductase, N-terminal domain Ank_5 PF13857.6 KOO35369.1 - 0.53 10.7 9.8 2 8.9 0.3 4.8 4 1 1 5 5 5 0 Ankyrin repeats (many copies) Ank PF00023.30 KOO35369.1 - 0.61 10.6 3.6 3.3 8.3 0.1 3.8 4 0 0 4 4 4 0 Ankyrin repeat LRR_4 PF12799.7 KOO35369.1 - 1 9.9 26.3 53 4.4 0.1 8.4 6 3 0 7 7 6 0 Leucine Rich repeats (2 copies) Cation_ATPase_C PF00689.21 KOO35371.1 - 3.7e-41 140.8 3.1 1.2e-40 139.2 3.1 1.9 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KOO35371.1 - 2.2e-33 115.3 1.7 2.2e-33 115.3 1.7 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 KOO35371.1 - 2.8e-14 53.9 1.9 9e-09 35.9 0.4 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOO35371.1 - 1e-12 47.9 0.0 2.8e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KOO35371.1 - 0.00044 20.1 1.1 0.002 17.9 0.4 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase NnrU PF07298.11 KOO35372.1 - 1.5e-37 129.1 12.8 2e-37 128.7 12.8 1.1 1 0 0 1 1 1 1 NnrU protein PEMT PF04191.13 KOO35372.1 - 0.003 17.9 0.4 0.0086 16.5 0.4 1.8 1 0 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.14 KOO35372.1 - 0.0076 16.6 0.5 0.016 15.6 0.5 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family AfaD PF05775.12 KOO35372.1 - 0.13 12.7 0.4 12 6.4 0.3 2.2 2 0 0 2 2 2 0 Enterobacteria AfaD invasin protein PARG_cat PF05028.14 KOO35374.1 - 9e-70 235.6 0.0 1.3e-69 235.1 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Dynamin_N PF00350.23 KOO35375.1 - 2.2e-13 50.6 0.0 3.6e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Dynamin family Roc PF08477.13 KOO35375.1 - 0.03 14.5 0.0 0.046 13.9 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 KOO35375.1 - 0.068 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 KOO35376.1 - 2e-07 31.2 0.0 5.9e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 KOO35376.1 - 0.084 13.0 0.2 0.17 12.1 0.2 1.5 1 0 0 1 1 1 0 Dynamin GTPase effector domain Arm PF00514.23 KOO35377.1 - 2.8e-12 46.2 10.8 0.00074 19.5 0.3 4.8 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO35377.1 - 8.2e-05 22.9 1.9 0.0055 17.1 0.2 3.4 3 1 0 3 3 3 1 HEAT repeats HEAT PF02985.22 KOO35377.1 - 0.00024 21.1 6.9 0.14 12.5 0.1 4.8 4 0 0 4 4 4 1 HEAT repeat Cnd1 PF12717.7 KOO35377.1 - 0.097 12.7 0.0 15 5.5 0.0 2.4 1 1 2 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KOO35377.1 - 2.2 8.9 8.6 58 4.3 0.0 4.7 5 0 0 5 5 5 0 HEAT-like repeat PIH1_CS PF18201.1 KOO35378.1 - 1e-09 38.6 0.0 3.1e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 PIH1 CS-like domain TPR_2 PF07719.17 KOO35378.1 - 0.025 14.7 6.4 0.48 10.7 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO35378.1 - 0.092 12.6 0.4 0.47 10.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO35380.1 - 7.4e-94 305.4 17.9 6.1e-13 48.2 0.1 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_12 PF13424.6 KOO35380.1 - 8.5e-94 308.0 24.2 3.9e-18 65.5 0.5 6.1 1 1 4 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 KOO35380.1 - 3.1e-37 124.9 4.0 0.00023 20.8 0.0 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_8 PF13181.6 KOO35380.1 - 1.6e-29 99.6 1.1 0.0026 17.8 0.0 8.7 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOO35380.1 - 1.8e-28 96.3 6.0 0.015 15.3 0.1 9.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_7 PF13176.6 KOO35380.1 - 2e-27 93.2 10.3 0.0013 18.6 0.1 8.8 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_MalT PF17874.1 KOO35380.1 - 8.2e-26 91.2 8.9 1.6e-11 44.2 0.9 4.0 1 1 2 3 3 3 3 MalT-like TPR region TPR_4 PF07721.14 KOO35380.1 - 3.2e-20 70.6 15.3 0.068 13.8 0.1 10.6 10 0 0 10 10 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 KOO35380.1 - 6.1e-16 58.8 29.3 0.00029 21.4 0.3 9.1 6 2 2 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOO35380.1 - 7.2e-16 57.3 6.0 3 8.4 0.0 8.6 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOO35380.1 - 7.6e-14 52.0 16.7 0.0034 17.9 0.4 5.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOO35380.1 - 2.3e-11 43.5 27.6 0.2 12.6 0.1 9.7 10 0 0 10 10 9 5 Tetratricopeptide repeat Osmo_CC PF08946.10 KOO35380.1 - 5.8e-07 29.7 7.5 31 4.9 0.0 7.6 8 0 0 8 8 7 0 Osmosensory transporter coiled coil TPR_5 PF12688.7 KOO35380.1 - 0.0006 20.0 9.7 0.17 12.1 0.6 4.7 1 1 4 5 5 5 3 Tetratrico peptide repeat HisKA_3 PF07730.13 KOO35380.1 - 0.00063 20.2 16.7 6.7 7.3 0.1 7.0 6 1 1 7 7 7 1 Histidine kinase RPN6_N PF18055.1 KOO35380.1 - 0.041 14.2 0.7 24 5.3 0.0 4.2 2 1 4 6 6 6 0 26S proteasome regulatory subunit RPN6 N-terminal domain PPR_1 PF12854.7 KOO35380.1 - 0.054 13.2 4.2 52 3.7 0.0 5.6 6 0 0 6 6 6 0 PPR repeat DUF3368 PF11848.8 KOO35380.1 - 0.64 9.8 6.7 2.7 7.9 0.2 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF3368) TPR_11 PF13414.6 KOO35380.1 - 0.75 9.5 8.9 70 3.2 0.0 6.1 7 0 0 7 7 7 0 TPR repeat TPR_21 PF09976.9 KOO35380.1 - 1.4 8.6 7.4 12 5.6 0.1 4.6 2 1 2 5 5 5 0 Tetratricopeptide repeat-like domain Alpha-amylase_N PF02903.14 KOO35383.1 - 0.038 14.2 0.4 0.24 11.6 0.4 2.4 1 0 0 1 1 1 0 Alpha amylase, N-terminal ig-like domain Ank_2 PF12796.7 KOO35384.1 - 1.4e-19 70.5 3.1 1e-10 42.0 0.7 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO35384.1 - 1.2e-16 60.8 1.2 2.2e-07 31.3 0.4 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO35384.1 - 2.6e-14 52.9 8.7 0.00044 20.6 0.6 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KOO35384.1 - 4.7e-13 49.1 7.0 7.7e-06 26.1 0.3 3.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35384.1 - 5.7e-11 41.6 1.6 0.13 12.9 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat TIR_2 PF13676.6 KOO35384.1 - 4.1e-06 27.4 0.0 1e-05 26.1 0.0 1.6 1 0 0 1 1 1 1 TIR domain Ish1 PF10281.9 KOO35384.1 - 0.0091 16.3 0.0 0.027 14.8 0.0 1.9 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein FAD_binding_5 PF00941.21 KOO35384.1 - 0.089 12.5 2.6 0.32 10.7 0.2 2.3 1 1 0 2 2 2 0 FAD binding domain in molybdopterin dehydrogenase SAM_3 PF18016.1 KOO35384.1 - 0.1 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Arm PF00514.23 KOO35385.1 - 2.3e-20 71.9 13.9 6.2e-05 22.9 0.2 4.8 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat Peptidase_M17_N PF02789.17 KOO35385.1 - 1.9e-05 24.5 0.5 2.7 7.8 0.0 4.2 1 1 4 5 5 5 3 Cytosol aminopeptidase family, N-terminal domain Cnd1 PF12717.7 KOO35385.1 - 0.0021 18.1 0.0 0.28 11.2 0.0 2.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 TPR_11 PF13414.6 KOO35386.1 - 0.0055 16.4 0.0 4.4 7.1 0.1 3.3 2 1 1 3 3 3 1 TPR repeat Toxin_19 PF08088.12 KOO35386.1 - 0.031 14.4 2.1 0.068 13.3 2.1 1.5 1 0 0 1 1 1 0 Conotoxin I-superfamily TPR_2 PF07719.17 KOO35386.1 - 0.064 13.4 6.5 0.38 11.0 4.8 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Aida_N PF08910.10 KOO35386.1 - 0.12 12.8 0.1 0.26 11.7 0.1 1.6 1 0 0 1 1 1 0 Aida N-terminus TPR_9 PF13371.6 KOO35386.1 - 0.23 11.6 8.0 2.5 8.3 5.1 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO35386.1 - 4.6 7.6 10.6 1.3 9.4 3.5 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat LRR_6 PF13516.6 KOO35388.1 - 0.00022 21.0 2.3 1 9.6 0.0 3.6 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 KOO35388.1 - 0.16 12.4 0.2 0.71 10.4 0.2 2.1 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) Nuc_sug_transp PF04142.15 KOO35389.1 - 2e-68 230.9 3.2 7.2e-49 166.6 0.1 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter UAA PF08449.11 KOO35389.1 - 2e-05 24.0 2.3 0.0015 17.8 4.4 2.4 2 1 0 2 2 2 1 UAA transporter family EamA PF00892.20 KOO35389.1 - 0.0005 20.2 8.1 0.0005 20.2 8.1 3.4 2 1 0 2 2 2 1 EamA-like transporter family TPT PF03151.16 KOO35389.1 - 0.0021 17.4 2.1 0.0021 17.4 2.1 1.7 2 0 0 2 2 2 1 Triose-phosphate Transporter family MgtC PF02308.16 KOO35389.1 - 0.048 14.0 9.0 0.085 13.2 0.8 2.8 3 0 0 3 3 3 0 MgtC family PhyH PF05721.13 KOO35390.1 - 6.2e-07 29.9 0.1 1.1e-06 29.1 0.1 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF3701 PF12482.8 KOO35391.1 - 0.22 11.6 2.1 9.8 6.3 0.1 3.6 3 1 1 4 4 4 0 Phage integrase protein Glyco_transf_8 PF01501.20 KOO35392.1 - 8.1e-15 55.1 0.0 1e-14 54.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 KOO35392.1 - 0.14 11.5 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Glucosyltransferase 24 Fip1 PF05182.13 KOO35393.1 - 1.6e-21 75.5 0.9 2.4e-21 75.0 0.9 1.2 1 0 0 1 1 1 1 Fip1 motif Dev_Cell_Death PF10539.9 KOO35394.1 - 7.4e-31 106.7 0.0 1e-30 106.2 0.0 1.2 1 0 0 1 1 1 1 Development and cell death domain DUF4333 PF14230.6 KOO35395.1 - 0.017 15.4 0.5 0.043 14.0 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4333) ATP-synt PF00231.19 KOO35396.1 - 8.5e-77 258.6 0.1 9.5e-77 258.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase Arm PF00514.23 KOO35398.1 - 0.00026 20.9 6.3 2.1 8.5 0.0 5.2 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 KOO35398.1 - 0.018 13.6 1.9 0.019 13.6 0.3 1.8 2 1 0 2 2 2 0 Adaptin N terminal region DUF749 PF05370.11 KOO35398.1 - 0.17 12.0 0.0 0.61 10.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF749) HEAT PF02985.22 KOO35398.1 - 2 8.9 4.5 3.1 8.3 0.1 3.4 3 0 0 3 3 3 0 HEAT repeat PC-Esterase PF13839.6 KOO35399.1 - 0.0015 18.3 0.1 1.1 8.9 0.0 2.4 2 0 0 2 2 2 2 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Laminin_G_3 PF13385.6 KOO35400.1 - 2.4e-25 89.5 0.1 3.7e-25 88.8 0.1 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sialidase PF02973.16 KOO35400.1 - 0.054 13.0 0.0 0.12 11.9 0.0 1.4 1 1 0 1 1 1 0 Sialidase, N-terminal domain SAP PF02037.27 KOO35400.1 - 0.069 12.9 2.3 0.14 12.0 0.1 2.6 3 0 0 3 3 3 0 SAP domain ARL2_Bind_BART PF11527.8 KOO35401.1 - 6.5e-07 29.5 0.6 9.6e-07 28.9 0.6 1.2 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART APOBEC4_like PF18774.1 KOO35401.1 - 0.099 12.6 0.3 0.13 12.2 0.3 1.3 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase RVT_2 PF07727.14 KOO35402.1 - 2.7e-14 53.4 0.0 3.8e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Neocarzinostat PF00960.18 KOO35402.1 - 0.076 13.0 1.9 1.1 9.2 1.4 2.3 2 0 0 2 2 2 0 Neocarzinostatin family HECT PF00632.25 KOO35403.1 - 2.3e-31 109.5 0.0 3.4e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) 4F5 PF04419.14 KOO35405.1 - 0.011 16.6 10.1 0.011 16.6 10.1 3.1 2 1 0 2 2 2 0 4F5 protein family TraC PF07820.12 KOO35405.1 - 0.013 15.8 3.0 0.013 15.8 3.0 2.7 2 1 0 2 2 2 0 TraC-like protein CCDC71L PF15374.6 KOO35405.1 - 0.89 8.8 9.2 1.3 8.2 9.0 1.5 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 71L Nop53 PF07767.11 KOO35405.1 - 3.7 6.8 12.2 4.4 6.6 12.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) LRR_4 PF12799.7 KOO35406.1 - 3.5e-25 87.7 17.5 4.4e-08 33.3 0.0 6.2 3 1 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO35406.1 - 9.1e-21 73.4 22.9 3.6e-06 26.6 1.0 5.8 2 1 3 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 KOO35406.1 - 3.7e-20 72.2 1.0 1.2e-11 44.4 0.0 2.8 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 KOO35406.1 - 6.2e-06 25.8 10.9 6.9 7.0 0.1 7.4 8 1 1 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 KOO35406.1 - 0.019 15.5 18.3 4 8.4 0.1 8.1 8 3 0 8 8 8 0 Leucine Rich Repeat RPGR1_C PF18111.1 KOO35408.1 - 2.5e-75 251.9 0.0 1.6e-10 41.1 0.0 8.1 7 1 1 8 8 8 8 Retinitis pigmentosa G-protein regulator interacting C-terminal C2-C2_1 PF11618.8 KOO35408.1 - 3.8e-07 30.3 0.0 1.8 8.7 0.0 5.3 6 0 0 6 6 6 2 First C2 domain of RPGR-interacting protein 1 YqzH PF14164.6 KOO35408.1 - 3e-05 24.0 1.4 22 5.2 0.0 4.8 4 0 0 4 4 4 0 YqzH-like protein RAI1 PF08652.11 KOO35408.1 - 0.00078 19.6 6.4 19 5.6 0.1 4.6 4 0 0 4 4 4 0 RAI1 like PD-(D/E)XK nuclease fn3_5 PF06280.12 KOO35408.1 - 0.0026 18.4 1.0 2.4e+02 2.4 0.0 5.6 6 0 0 6 6 6 0 Fn3-like domain SnAPC_2_like PF11035.8 KOO35408.1 - 0.0037 17.5 0.6 48 4.0 0.0 4.2 4 0 0 4 4 4 0 Small nuclear RNA activating complex subunit 2, SNAP190 Myb DUF4472 PF14739.6 KOO35408.1 - 0.0071 17.1 0.6 7.9 7.3 0.0 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4472) NT-C2 PF10358.9 KOO35408.1 - 0.0095 15.7 0.0 1.3 8.8 0.0 3.5 3 0 0 3 3 3 1 N-terminal C2 in EEIG1 and EHBP1 proteins SCO1-SenC PF02630.14 KOO35408.1 - 0.04 13.8 0.0 2.4 8.1 0.0 3.2 3 0 0 3 3 3 0 SCO1/SenC DUF1937 PF09152.10 KOO35408.1 - 0.1 13.4 2.1 42 5.0 0.0 3.9 5 0 0 5 5 5 0 Domain of unknown function (DUF1937) Ribophorin_II PF05817.14 KOO35408.1 - 0.14 10.7 7.3 24 3.3 0.1 4.3 5 0 0 5 5 5 0 Oligosaccharyltransferase subunit Ribophorin II PK PF00224.21 KOO35412.1 - 1.3e-139 465.0 0.2 2.9e-139 463.8 0.2 1.5 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KOO35412.1 - 5.5e-20 71.7 0.2 1.5e-19 70.4 0.2 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KOO35412.1 - 0.0026 17.0 0.2 0.017 14.3 0.2 2.2 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family ACT_6 PF13740.6 KOO35413.1 - 1.4e-15 57.0 0.0 1.7e-10 40.7 0.0 2.8 3 0 0 3 3 3 2 ACT domain Mpv17_PMP22 PF04117.12 KOO35413.1 - 1.2e-10 41.5 1.5 2.4e-10 40.5 1.5 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family ACT PF01842.25 KOO35413.1 - 9.5e-08 31.7 0.0 0.00052 19.7 0.0 2.5 2 0 0 2 2 2 2 ACT domain ACT_4 PF13291.6 KOO35413.1 - 2.7e-06 27.9 0.0 0.021 15.4 0.0 2.3 2 0 0 2 2 2 2 ACT domain Cupin_8 PF13621.6 KOO35414.1 - 0.051 13.3 0.0 0.051 13.3 0.0 1.1 1 0 0 1 1 1 0 Cupin-like domain EF-hand_7 PF13499.6 KOO35415.1 - 2.9e-10 40.4 0.1 8.1e-10 39.0 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO35415.1 - 1.4e-09 37.6 1.0 0.00046 20.0 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO35415.1 - 9.5e-09 34.2 0.0 0.00035 19.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO35415.1 - 1.1e-07 31.2 0.1 2.1e-05 24.1 0.2 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KOO35415.1 - 1.4e-07 30.7 0.3 0.00014 21.2 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 KOO35415.1 - 0.043 14.1 0.0 0.17 12.2 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO35415.1 - 0.21 11.9 0.0 0.4 11.0 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Ank_5 PF13857.6 KOO35416.1 - 6.7e-20 70.9 1.3 7.1e-10 38.9 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO35416.1 - 3.7e-16 59.5 0.1 1.8e-08 34.8 0.0 2.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO35416.1 - 2.1e-13 50.5 2.2 1.1e-05 25.9 0.2 3.7 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35416.1 - 5.7e-12 44.7 0.1 0.00062 20.0 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOO35416.1 - 1.2e-09 38.1 0.2 0.00036 20.8 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Kelch_1 PF01344.25 KOO35417.1 - 5.7e-24 83.4 14.3 2.4e-05 23.8 0.4 6.5 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KOO35417.1 - 4.9e-17 61.6 6.6 0.0024 18.1 0.0 6.4 4 3 2 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KOO35417.1 - 6.5e-17 61.3 4.8 0.0041 17.1 0.1 5.9 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO35417.1 - 5e-15 55.1 0.6 0.0055 16.7 0.0 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 KOO35417.1 - 5.3e-14 51.5 4.6 0.023 14.6 0.0 7.1 7 0 0 7 7 7 3 Kelch motif Kelch_3 PF13415.6 KOO35417.1 - 6.4e-12 45.5 8.0 0.0057 16.9 0.0 5.8 6 0 0 6 6 6 3 Galactose oxidase, central domain EF-hand_6 PF13405.6 KOO35418.1 - 7.9e-09 34.8 0.0 0.0033 17.2 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO35418.1 - 7.4e-08 31.4 0.0 0.016 14.7 0.0 3.3 3 0 0 3 3 3 2 EF hand DUF1289 PF06945.13 KOO35418.1 - 1.2e-07 31.4 15.8 2.5 8.0 0.1 8.0 4 4 6 10 10 10 3 Protein of unknown function (DUF1289) HMG_box PF00505.19 KOO35418.1 - 1.5e-07 31.7 37.4 0.097 13.1 0.5 8.2 4 4 5 9 9 9 3 HMG (high mobility group) box DUF2299 PF10061.9 KOO35418.1 - 4.2e-06 26.5 7.4 4.2 7.1 0.0 6.5 5 1 2 7 7 7 1 Uncharacterized conserved protein (DUF2299) DUF3106 PF11304.8 KOO35418.1 - 1e-05 25.9 25.7 0.029 14.8 3.8 5.3 1 1 1 3 3 3 2 Protein of unknown function (DUF3106) EF-hand_7 PF13499.6 KOO35418.1 - 2.5e-05 24.6 0.3 0.0019 18.6 0.1 3.0 1 1 2 3 3 3 2 EF-hand domain pair DUF4473 PF14747.6 KOO35418.1 - 0.00011 22.6 22.4 0.023 15.3 0.1 5.6 3 1 1 5 5 5 2 Domain of unknown function (DUF4473) LTXXQ PF07813.12 KOO35418.1 - 0.00016 22.3 46.6 2.2 9.1 15.9 5.7 1 1 3 4 4 4 2 LTXXQ motif family protein Catalase-rel PF06628.12 KOO35418.1 - 0.00032 20.9 14.2 14 6.0 0.0 8.1 6 3 3 9 9 9 0 Catalase-related immune-responsive WHIM1 PF15612.6 KOO35418.1 - 0.0015 18.0 0.0 14 5.4 0.0 5.2 5 1 1 6 6 6 0 WSTF, HB1, Itc1p, MBD9 motif 1 HSP9_HSP12 PF04119.12 KOO35418.1 - 0.0026 18.1 0.2 0.33 11.4 0.0 3.7 3 1 0 3 3 3 1 Heat shock protein 9/12 EF-hand_8 PF13833.6 KOO35418.1 - 0.0031 17.3 0.1 1.8 8.5 0.0 3.3 2 1 1 3 3 3 1 EF-hand domain pair MgtE_N PF03448.17 KOO35418.1 - 0.0073 16.9 19.0 0.41 11.3 1.3 4.8 4 1 0 4 4 4 2 MgtE intracellular N domain PG_binding_3 PF09374.10 KOO35418.1 - 0.041 14.1 4.6 3 8.2 0.0 3.9 2 1 0 3 3 3 0 Predicted Peptidoglycan domain IspD PF01128.19 KOO35418.1 - 0.093 12.5 0.2 0.16 11.7 0.2 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase EF-hand_5 PF13202.6 KOO35418.1 - 0.1 12.2 1.4 8.6 6.0 0.0 3.1 3 0 0 3 3 3 0 EF hand TerB_N PF13208.6 KOO35418.1 - 0.1 12.3 11.4 2.7 7.7 0.1 4.5 3 2 1 4 4 4 0 TerB N-terminal domain COX4 PF02936.14 KOO35418.1 - 0.23 11.4 12.9 4.6 7.3 0.3 5.0 2 2 3 5 5 5 0 Cytochrome c oxidase subunit IV Sdh5 PF03937.16 KOO35418.1 - 0.39 10.7 6.4 4.5 7.3 0.0 5.1 4 3 0 5 5 5 0 Flavinator of succinate dehydrogenase HMG_box_2 PF09011.10 KOO35418.1 - 0.98 10.1 41.3 2 9.1 0.9 7.7 4 4 4 8 8 8 0 HMG-box domain DUF1043 PF06295.12 KOO35418.1 - 1.7 8.7 3.9 17 5.4 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) CSTF_C PF14304.6 KOO35418.1 - 4.1 7.1 8.4 29 4.4 0.2 4.5 5 0 0 5 5 5 0 Transcription termination and cleavage factor C-terminal DUF3949 PF13133.6 KOO35418.1 - 4.6 7.8 10.5 1e+02 3.5 0.0 5.7 4 2 2 6 6 6 0 Protein of unknown function (DUF3949) Dynein_C PF18199.1 KOO35419.1 - 7.2e-53 179.8 0.0 1.3e-52 179.0 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KOO35419.1 - 5.4e-23 81.3 0.0 1.2e-22 80.1 0.0 1.5 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 KOO35419.1 - 1.5e-21 76.9 0.0 3.2e-21 75.9 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOO35419.1 - 0.0057 16.7 0.0 0.2 11.7 0.0 2.7 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain Dynein_heavy PF03028.15 KOO35420.1 - 8.4e-33 113.0 0.0 1.1e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 KOO35420.1 - 5.1e-09 36.1 0.0 7.7e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Rubis-subs-bind PF09273.11 KOO35422.1 - 0.00022 21.9 0.5 0.00053 20.7 0.5 1.6 1 1 0 1 1 1 1 Rubisco LSMT substrate-binding Methyltr_RsmB-F PF01189.17 KOO35423.1 - 1e-10 41.6 0.0 1.6e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PUA PF01472.20 KOO35423.1 - 2.6e-08 33.7 0.3 4.7e-08 32.9 0.3 1.5 1 0 0 1 1 1 1 PUA domain Pkinase PF00069.25 KOO35424.1 - 7.8e-65 218.8 0.0 8.9e-65 218.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35424.1 - 1.3e-31 109.8 0.0 1.6e-31 109.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO35424.1 - 0.02 14.8 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO35424.1 - 0.027 13.8 0.0 0.46 9.7 0.0 2.0 1 1 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 KOO35424.1 - 0.25 10.3 0.0 0.48 9.3 0.0 1.4 2 0 0 2 2 2 0 Haspin like kinase domain DnaJ PF00226.31 KOO35427.1 - 1e-09 38.3 0.0 2.8e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain TFIIF_alpha PF05793.12 KOO35427.1 - 0.0028 16.4 8.9 0.0028 16.4 8.9 2.3 3 0 0 3 3 3 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Agenet PF05641.12 KOO35427.1 - 0.053 14.0 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 Agenet domain AAA_23 PF13476.6 KOO35427.1 - 0.84 10.1 5.5 13 6.2 1.2 2.6 2 0 0 2 2 2 0 AAA domain MCU PF04678.13 KOO35427.1 - 4.3 7.4 11.3 0.56 10.3 1.0 2.9 3 0 0 3 3 3 0 Mitochondrial calcium uniporter AP2 PF00847.20 KOO35428.1 - 1.8e-12 47.2 47.8 0.062 13.5 0.1 11.6 10 1 0 10 10 10 8 AP2 domain DUF1816 PF08846.10 KOO35428.1 - 0.078 13.0 0.0 2 8.5 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1816) IF3_N PF05198.16 KOO35428.1 - 0.15 12.3 3.2 1.9e+02 2.4 0.0 5.6 8 0 0 8 8 8 0 Translation initiation factor IF-3, N-terminal domain Aconitase PF00330.20 KOO35430.1 - 1.4e-155 518.8 0.1 1.7e-155 518.5 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KOO35430.1 - 9.7e-33 113.3 0.0 1.8e-32 112.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DEAD PF00270.29 KOO35431.1 - 2.1e-36 125.3 0.0 1.1e-33 116.5 0.0 2.5 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO35431.1 - 1.5e-30 105.7 0.0 3.8e-30 104.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOO35431.1 - 0.08 13.2 0.3 0.42 10.9 0.3 2.1 1 1 0 1 1 1 0 AAA domain ERCC3_RAD25_C PF16203.5 KOO35431.1 - 0.19 10.9 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Peptidase_C1 PF00112.23 KOO35432.1 - 2.4e-41 142.2 0.0 4.1e-41 141.5 0.0 1.3 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KOO35432.1 - 0.027 13.3 0.5 0.04 12.7 0.5 1.1 1 0 0 1 1 1 0 Peptidase C1-like family Ank_2 PF12796.7 KOO35434.1 - 8e-09 36.0 0.0 1.9e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO35434.1 - 1e-08 35.2 0.2 9.3e-05 22.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KOO35434.1 - 3.6e-08 33.8 0.4 0.011 16.3 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35434.1 - 1.9e-06 27.8 0.2 0.067 13.8 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KOO35434.1 - 6.4e-06 26.3 1.4 0.013 15.8 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Lon_C PF05362.13 KOO35435.1 - 4.1e-64 215.9 0.0 1.1e-61 207.9 0.0 2.3 1 1 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 KOO35435.1 - 2.1e-12 47.6 0.0 6e-08 33.2 0.0 2.6 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO35435.1 - 1.2e-06 28.6 0.0 1.1e-05 25.5 0.0 2.3 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 KOO35435.1 - 1.4e-06 28.2 0.0 3.4e-06 26.9 0.0 1.8 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 KOO35435.1 - 2.3e-05 24.9 0.2 0.00018 21.9 0.0 2.4 2 1 0 3 3 3 1 AAA ATPase domain AAA_PrkA PF08298.11 KOO35435.1 - 2.7e-05 23.3 0.0 4.4e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.12 KOO35435.1 - 0.00021 21.1 0.0 0.00042 20.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KOO35435.1 - 0.0013 18.9 0.3 0.067 13.4 0.1 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KOO35435.1 - 0.0039 17.1 0.0 0.008 16.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase IstB_IS21 PF01695.17 KOO35435.1 - 0.0074 16.0 0.0 0.027 14.2 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_3 PF07726.11 KOO35435.1 - 0.0092 15.8 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KOO35435.1 - 0.011 16.3 0.1 0.026 15.1 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOO35435.1 - 0.012 15.9 0.0 0.031 14.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KOO35435.1 - 0.036 13.3 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 KOO35435.1 - 0.037 14.4 0.0 0.065 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 KOO35435.1 - 0.09 12.7 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 KOO35435.1 - 0.12 12.9 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 KOO35435.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 KOO35435.1 - 0.16 11.7 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain LON_substr_bdg PF02190.16 KOO35436.1 - 6e-16 58.9 0.0 8.7e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain Amidohydro_2 PF04909.14 KOO35437.1 - 8.8e-07 29.0 1.6 8.8e-07 29.0 1.6 1.8 2 1 0 2 2 2 1 Amidohydrolase Peptidase_S49_N PF08496.10 KOO35437.1 - 0.011 15.8 0.4 0.017 15.2 0.4 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal HK97-gp10_like PF04883.12 KOO35437.1 - 0.12 13.4 1.3 0.32 12.0 1.1 1.8 2 0 0 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component EzrA PF06160.12 KOO35437.1 - 0.14 10.3 0.3 0.19 9.8 0.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA STAG PF08514.11 KOO35437.1 - 0.17 11.8 1.2 0.3 11.0 1.2 1.3 1 0 0 1 1 1 0 STAG domain TPR_1 PF00515.28 KOO35438.1 - 0.00021 20.9 2.0 0.71 9.8 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO35438.1 - 0.00033 20.5 12.5 0.013 15.5 0.4 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO35438.1 - 0.00042 20.9 1.8 0.00042 20.9 1.8 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO35438.1 - 0.0031 17.1 0.3 0.28 10.9 0.1 2.9 2 1 1 3 3 3 1 TPR repeat TPR_19 PF14559.6 KOO35438.1 - 0.054 14.0 2.2 0.054 14.0 2.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat NARP1 PF12569.8 KOO35438.1 - 0.094 11.6 0.6 0.27 10.1 0.0 1.8 1 1 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 KOO35438.1 - 0.46 10.7 3.7 0.29 11.3 0.9 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO35438.1 - 3.9 7.8 9.3 7.7 6.9 0.2 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L3 PF00297.22 KOO35439.1 - 2.4e-19 69.6 4.2 4.6e-16 58.8 2.5 2.4 1 1 1 2 2 2 2 Ribosomal protein L3 Ribosomal_S30 PF04758.14 KOO35440.1 - 6.5e-30 103.1 11.5 7.3e-30 103.0 11.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 PP2C PF00481.21 KOO35442.1 - 3.6e-43 148.1 0.7 4.6e-28 98.6 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 KOO35442.1 - 0.00082 19.3 0.1 0.0086 16.0 0.0 2.1 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KOO35442.1 - 0.0019 17.9 0.1 0.019 14.6 0.1 2.1 2 0 0 2 2 2 1 Protein phosphatase 2C COesterase PF00135.28 KOO35443.1 - 1.1e-87 295.0 0.0 1.6e-62 212.1 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 KOO35443.1 - 2.7e-05 24.1 0.7 0.00019 21.3 0.1 2.4 3 0 0 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOO35443.1 - 0.026 14.0 0.0 0.049 13.1 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family PAN_2 PF08276.11 KOO35443.1 - 0.037 14.1 1.1 0.088 12.9 1.1 1.6 1 0 0 1 1 1 0 PAN-like domain Sec20 PF03908.13 KOO35444.1 - 0.14 12.1 0.6 1.2 9.1 0.1 2.5 2 1 1 3 3 3 0 Sec20 ISG65-75 PF11727.8 KOO35444.1 - 0.71 9.1 7.5 0.42 9.8 5.1 1.8 2 0 0 2 2 2 0 Invariant surface glycoprotein OmpH PF03938.14 KOO35444.1 - 2 8.8 19.4 0.44 10.9 9.9 3.1 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) HBS1_N PF08938.10 KOO35444.1 - 2.3 8.6 6.3 4.1 7.8 4.3 2.3 2 0 0 2 2 2 0 HBS1 N-terminus 5_nucleotid PF05761.14 KOO35444.1 - 3.8 6.3 7.7 2.3 7.0 5.8 1.6 1 1 1 2 2 2 0 5' nucleotidase family HIP1_clath_bdg PF16515.5 KOO35444.1 - 5.3 7.7 22.9 0.57 10.8 10.0 3.7 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 KOO35444.1 - 6.8 6.0 24.7 0.52 9.6 14.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF724 PF05266.14 KOO35444.1 - 8.9 6.1 10.1 3.2 7.6 5.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF724) PP2C PF00481.21 KOO35445.1 - 1.4e-64 218.2 0.0 1.8e-64 217.9 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO35445.1 - 1.5e-08 34.5 0.3 2.6e-08 33.8 0.3 1.3 1 1 0 1 1 1 1 Protein phosphatase 2C zf-HYPF PF07503.12 KOO35446.1 - 9.6e-05 22.1 15.3 0.79 9.5 0.5 5.1 4 0 0 4 4 4 4 HypF finger DNA_RNApol_7kD PF03604.13 KOO35446.1 - 0.17 11.6 7.8 16 5.2 0.1 4.7 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit zf-CCHH PF10283.9 KOO35446.1 - 6.7 6.8 15.9 30 4.7 0.2 4.5 4 0 0 4 4 4 0 PBZ domain CUB PF00431.20 KOO35447.1 - 5.3e-12 46.1 0.0 2.5e-09 37.4 0.0 2.6 2 0 0 2 2 2 2 CUB domain zf-RING_2 PF13639.6 KOO35447.1 - 1.5e-11 44.5 5.6 1.5e-11 44.5 5.6 5.3 4 1 1 5 5 5 1 Ring finger domain zf-RING_11 PF17123.5 KOO35447.1 - 4e-11 42.5 3.8 1.4e-10 40.7 3.8 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KOO35447.1 - 7.4e-07 28.9 5.4 7.4e-07 28.9 5.4 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOO35447.1 - 2.4e-06 27.7 5.9 2.4e-06 27.7 5.9 2.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOO35447.1 - 6.5e-06 25.9 5.4 6.5e-06 25.9 5.4 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO35447.1 - 7e-06 25.9 3.9 7e-06 25.9 3.9 5.5 7 0 0 7 7 7 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO35447.1 - 2.2e-05 24.4 3.9 4.5e-05 23.4 2.3 2.6 1 1 0 1 1 1 1 RING-type zinc-finger Cadherin-like PF12733.7 KOO35447.1 - 0.00031 21.2 2.3 4.9 7.7 0.1 5.0 5 0 0 5 5 5 1 Cadherin-like beta sandwich domain zf-ANAPC11 PF12861.7 KOO35447.1 - 0.00034 20.6 1.9 0.00034 20.6 1.9 4.6 4 1 2 6 6 6 1 Anaphase-promoting complex subunit 11 RING-H2 finger LVIVD PF08309.11 KOO35449.1 - 1.5e-48 161.9 52.8 5.6e-11 41.6 4.3 6.3 6 0 0 6 6 6 6 LVIVD repeat Chitin_bind_4 PF00379.23 KOO35449.1 - 5.6e-05 23.6 7.9 16 6.1 0.3 6.0 6 0 0 6 6 6 2 Insect cuticle protein SBP56 PF05694.11 KOO35449.1 - 0.00093 18.1 0.0 0.33 9.7 0.0 3.7 2 1 3 5 5 5 1 56kDa selenium binding protein (SBP56) Beta_propel PF09826.9 KOO35449.1 - 0.006 15.5 0.0 12 4.6 0.0 3.9 4 0 0 4 4 4 1 Beta propeller domain Lactonase PF10282.9 KOO35449.1 - 0.007 15.7 5.1 4.9 6.3 0.0 3.7 2 1 2 4 4 4 3 Lactonase, 7-bladed beta-propeller GCV_T_C PF08669.11 KOO35449.1 - 0.0096 15.8 0.1 0.039 13.9 0.1 2.1 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain IQ PF00612.27 KOO35450.1 - 0.055 13.3 0.2 0.15 11.9 0.2 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Acetyltransf_10 PF13673.7 KOO35451.1 - 4.3e-05 23.5 0.0 8.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOO35451.1 - 0.0031 17.7 0.0 0.0064 16.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family DUF2064 PF09837.9 KOO35451.1 - 0.22 11.3 2.0 0.43 10.4 0.1 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2064) IBR PF01485.21 KOO35453.1 - 1.1e-18 67.2 48.5 1.3e-12 47.7 4.3 4.9 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 KOO35453.1 - 0.00029 20.6 2.0 0.00029 20.6 2.0 4.9 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOO35453.1 - 0.0016 18.7 6.2 0.0016 18.7 6.2 4.3 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 KOO35453.1 - 0.0035 17.2 7.6 0.0035 17.2 7.6 4.7 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOO35453.1 - 0.0045 16.8 6.6 0.0045 16.8 6.6 4.6 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO35453.1 - 0.029 14.2 2.3 0.029 14.2 2.3 4.8 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 CENP-B_dimeris PF09026.10 KOO35456.1 - 0.0042 17.4 1.4 0.0051 17.2 1.4 1.1 1 0 0 1 1 1 1 Centromere protein B dimerisation domain T2SSC PF11356.8 KOO35456.1 - 0.044 13.7 1.3 0.048 13.6 1.3 1.1 1 0 0 1 1 1 0 Type II secretion system protein C BRCT PF00533.26 KOO35457.1 - 4.1e-06 27.1 0.0 1.3e-05 25.5 0.0 1.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KOO35457.1 - 0.0047 17.3 0.0 1.3 9.4 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RACo_linker PF17650.1 KOO35457.1 - 0.052 13.4 0.1 0.15 11.9 0.1 1.8 1 0 0 1 1 1 0 RACo linker region DUF4033 PF13225.6 KOO35457.1 - 0.13 12.3 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4033) FliD_N PF02465.18 KOO35457.1 - 2.9 8.7 7.5 0.38 11.5 3.0 1.9 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Arm PF00514.23 KOO35458.1 - 6.7e-14 51.4 10.5 0.0035 17.3 0.0 5.1 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat EF-hand_6 PF13405.6 KOO35458.1 - 1.8e-06 27.4 0.0 2.8e-05 23.7 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO35458.1 - 2.5e-06 27.8 0.1 0.00098 19.5 0.0 1.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO35458.1 - 8e-06 25.6 0.1 0.0013 18.5 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO35458.1 - 1.5e-05 24.2 0.1 0.00011 21.5 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO35458.1 - 1.7e-05 24.0 0.1 4.3e-05 22.8 0.1 1.7 1 0 0 1 1 1 1 EF hand HEAT PF02985.22 KOO35458.1 - 0.0016 18.5 1.7 11 6.6 0.1 4.9 4 0 0 4 4 4 1 HEAT repeat Arm_2 PF04826.13 KOO35458.1 - 0.23 10.9 0.1 1.6 8.1 0.0 2.0 1 1 1 2 2 2 0 Armadillo-like EF-hand_1 PF00036.32 KOO35461.1 - 1.7e-22 77.2 5.3 6.9e-05 22.1 0.6 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO35461.1 - 4e-20 72.0 0.2 3.6e-09 36.9 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO35461.1 - 1.4e-17 62.1 2.4 0.0025 17.6 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO35461.1 - 2.7e-17 61.4 5.9 1.3e-05 24.4 0.0 4.7 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOO35461.1 - 1.7e-09 37.4 7.0 2.9e-05 23.8 0.3 4.0 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO35461.1 - 8.3e-07 29.3 0.3 5.5e-05 23.4 0.0 2.7 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO35461.1 - 0.00045 20.3 4.5 0.0025 18.0 1.7 2.7 2 1 0 2 2 2 1 Dockerin type I domain EF-hand_4 PF12763.7 KOO35461.1 - 0.0026 17.7 4.7 3.4 7.7 0.0 3.8 2 2 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO35461.1 - 0.11 12.8 0.6 0.47 10.8 0.1 2.1 2 1 0 2 2 2 0 EF-hand domain FG-GAP PF01839.23 KOO35461.1 - 1.6 8.9 6.5 16 5.7 0.1 3.4 4 0 0 4 4 4 0 FG-GAP repeat VCBS PF13517.6 KOO35461.1 - 4.7 7.9 6.6 45 4.7 0.0 3.5 3 1 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Borrelia_P83 PF05262.11 KOO35462.1 - 0.24 9.8 4.8 0.18 10.3 3.6 1.3 2 0 0 2 2 2 0 Borrelia P83/100 protein YlqD PF11068.8 KOO35462.1 - 0.45 10.9 2.3 24 5.3 4.9 2.0 2 0 0 2 2 2 0 YlqD protein Atg14 PF10186.9 KOO35462.1 - 6.8 5.7 7.0 12 4.8 7.0 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ISG65-75 PF11727.8 KOO35462.1 - 7.4 5.7 9.9 12 5.1 9.9 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein EPSP_synthase PF00275.20 KOO35463.1 - 1.5e-65 221.6 0.1 2.9e-39 135.0 0.0 3.0 2 1 0 2 2 2 2 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) TPD PF14811.6 KOO35464.1 - 2.1e-13 50.3 0.2 4.7e-12 46.0 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function TPD sequence-motif Rad60-SLD PF11976.8 KOO35464.1 - 0.0077 16.0 0.0 0.45 10.4 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOO35464.1 - 0.019 14.7 0.0 0.042 13.6 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin family RecC_C PF17946.1 KOO35464.1 - 0.023 14.5 0.1 0.042 13.6 0.1 1.5 1 0 0 1 1 1 0 RecC C-terminal domain Plexin_cytopl PF08337.12 KOO35464.1 - 0.16 10.6 0.0 0.23 10.1 0.0 1.1 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain DUF3106 PF11304.8 KOO35465.1 - 0.13 12.8 4.7 20 5.7 0.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) Myb_DNA-binding PF00249.31 KOO35466.1 - 4.9e-26 90.7 1.1 6.9e-16 58.2 0.1 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO35466.1 - 7.6e-16 58.1 0.2 1.1e-13 51.2 0.0 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 KOO35466.1 - 0.006 16.6 0.7 0.27 11.4 0.1 2.2 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain PARP PF00644.20 KOO35468.1 - 1.2e-11 44.5 0.0 2.8e-11 43.4 0.0 1.6 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PheRS_DBD1 PF18552.1 KOO35468.1 - 0.13 12.1 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 PheRS DNA binding domain 1 Methyltransf_25 PF13649.6 KOO35470.1 - 0.044 14.5 0.0 0.095 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 KOO35470.1 - 0.062 12.9 0.1 0.089 12.4 0.1 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 KOO35470.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 KOO35470.1 - 0.16 11.3 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family EF-hand_7 PF13499.6 KOO35471.1 - 2.7e-08 34.2 0.8 5.5e-05 23.5 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOO35471.1 - 1e-07 32.1 0.0 8.1e-05 22.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 KOO35471.1 - 5.2e-07 29.1 0.1 0.12 12.4 0.0 3.7 4 1 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 KOO35471.1 - 2.2e-06 26.8 0.2 0.14 11.8 0.0 3.5 4 0 0 4 4 4 2 EF hand EFhand_Ca_insen PF08726.10 KOO35471.1 - 0.0016 18.5 0.1 0.003 17.6 0.1 1.3 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_8 PF13833.6 KOO35471.1 - 0.0018 18.1 0.3 1.1 9.2 0.0 3.5 2 2 2 4 4 4 1 EF-hand domain pair Ribosomal_S13 PF00416.22 KOO35474.1 - 1.9e-52 177.0 2.7 2.2e-52 176.8 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 KOO35474.1 - 0.0076 15.1 0.1 0.015 14.1 0.1 1.5 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) EF-hand_8 PF13833.6 KOO35474.1 - 0.025 14.4 0.1 0.085 12.7 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair Chordopox_A30L PF06015.12 KOO35474.1 - 0.086 12.7 0.1 0.26 11.1 0.0 1.9 2 0 0 2 2 2 0 Chordopoxvirus A30L protein His_Phos_1 PF00300.22 KOO35475.1 - 8.3e-44 149.6 0.0 1.9e-43 148.4 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Cyclin_N PF00134.23 KOO35475.1 - 4.1e-11 42.7 0.1 8e-11 41.8 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 KOO35475.1 - 0.016 15.6 0.1 0.042 14.2 0.1 1.7 1 1 0 1 1 1 0 Cyclin C-terminal domain UPF0193 PF05250.11 KOO35476.1 - 5.8e-12 45.9 0.4 1e-11 45.1 0.4 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) TauE PF01925.19 KOO35477.1 - 4.9e-25 88.5 24.6 1.3e-12 47.8 3.1 2.4 1 1 0 2 2 2 2 Sulfite exporter TauE/SafE BTAD PF03704.17 KOO35482.1 - 0.13 12.7 0.0 0.33 11.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial transcriptional activator domain RVT_2 PF07727.14 KOO35484.1 - 9.4e-11 41.8 0.0 1.8e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GPS PF01825.21 KOO35485.1 - 9.1e-08 32.5 9.4 2e-07 31.4 9.4 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PDZ_2 PF13180.6 KOO35485.1 - 0.0041 17.4 0.0 0.013 15.8 0.0 1.9 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOO35485.1 - 0.018 14.9 1.4 0.052 13.4 0.1 2.4 2 0 0 2 2 2 0 PDZ domain DUF212 PF02681.14 KOO35485.1 - 0.26 11.4 4.4 1.4 9.1 4.4 2.2 1 0 0 1 1 1 0 Divergent PAP2 family FliG_M PF14841.6 KOO35485.1 - 0.43 10.8 2.2 16 5.8 0.2 3.0 3 0 0 3 3 3 0 FliG middle domain DUF11 PF01345.18 KOO35485.1 - 6.9 7.0 8.5 2.6 8.4 2.3 3.1 2 0 0 2 2 2 0 Domain of unknown function DUF11 Cyclotide PF03784.13 KOO35487.1 - 1.1 9.4 4.4 0.4 10.8 0.4 2.4 2 0 0 2 2 2 0 Cyclotide family TFIIS_M PF07500.14 KOO35489.1 - 3.9e-18 66.0 0.0 6.7e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain DUF761 PF05553.11 KOO35489.1 - 0.055 13.0 0.3 0.1 12.2 0.3 1.3 1 0 0 1 1 1 0 Cotton fibre expressed protein Pkinase PF00069.25 KOO35490.1 - 8.8e-39 133.4 0.0 1.5e-38 132.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35490.1 - 4.4e-16 58.9 0.0 6.7e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO35490.1 - 0.0029 17.0 0.0 0.0042 16.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO35490.1 - 0.0068 16.3 1.5 0.0069 16.3 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF2341 PF10102.9 KOO35491.1 - 0.17 12.5 0.1 1.3 9.7 0.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF2341) Filamin PF00630.19 KOO35492.1 - 0.00036 21.3 0.0 0.00036 21.3 0.0 1.2 1 0 0 1 1 1 1 Filamin/ABP280 repeat GDP_Man_Dehyd PF16363.5 KOO35493.1 - 3.9e-157 522.9 0.0 4.5e-157 522.7 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOO35493.1 - 6e-73 245.3 0.1 7.8e-73 244.9 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOO35493.1 - 0.0038 16.4 0.0 0.0055 15.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KOO35493.1 - 0.19 10.8 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MRP-L47 PF06984.13 KOO35494.1 - 0.011 15.9 0.5 0.02 15.0 0.5 1.5 1 0 0 1 1 1 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 KOO35494.1 - 0.012 15.6 0.5 0.033 14.1 0.5 1.8 1 0 0 1 1 1 0 Ribosomal L29 protein TPR_2 PF07719.17 KOO35495.1 - 1.3e-14 53.0 19.4 0.00096 19.1 0.3 6.0 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOO35495.1 - 2.4e-13 49.3 1.0 0.0032 17.2 0.3 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO35495.1 - 2.6e-13 50.4 36.5 1.9e-08 34.8 7.6 4.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO35495.1 - 1.3e-11 44.6 22.6 4e-05 23.8 1.8 4.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO35495.1 - 1.6e-09 37.3 3.8 0.0035 17.0 0.0 4.8 4 1 1 5 5 5 3 TPR repeat TPR_10 PF13374.6 KOO35495.1 - 9.8e-08 31.6 22.3 0.11 12.4 0.1 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO35495.1 - 3.1e-06 27.0 1.1 0.013 15.7 0.1 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO35495.1 - 4.4e-06 26.7 1.2 0.063 13.7 0.0 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO35495.1 - 0.00016 21.4 5.2 0.098 12.7 0.3 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO35495.1 - 0.0012 19.3 9.8 0.12 12.9 0.6 3.7 2 1 2 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO35495.1 - 0.033 14.4 2.4 11 6.3 0.0 3.8 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 KOO35495.1 - 0.033 15.0 30.5 0.77 10.7 0.7 6.2 2 1 4 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO35495.1 - 0.062 14.0 14.0 1.2 10.0 0.4 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO35495.1 - 0.075 13.2 15.3 0.39 10.9 0.5 3.4 1 1 2 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 KOO35495.1 - 4.5 7.7 19.0 2.4 8.6 3.8 3.5 2 1 1 3 3 3 0 Bacterial transcriptional activator domain SNAP PF14938.6 KOO35495.1 - 6.4 6.1 6.5 7.2 5.9 4.7 2.0 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP E2R135 PF11570.8 KOO35498.1 - 0.0014 18.9 3.3 0.0061 16.8 3.3 2.1 1 0 0 1 1 1 1 Coiled-coil receptor-binding R-domain of colicin E2 HEPN_Swt1 PF18731.1 KOO35498.1 - 0.33 11.3 8.4 1.3 9.4 0.1 2.8 2 1 0 2 2 2 0 Swt1-like HEPN DUF4600 PF15372.6 KOO35498.1 - 0.61 10.5 0.0 0.61 10.5 0.0 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4600) DUF374 PF04028.13 KOO35499.1 - 0.056 13.0 0.1 0.065 12.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF374) Strep_SA_rep PF06696.11 KOO35500.1 - 0.0054 16.7 1.4 0.01 15.8 1.4 1.4 1 0 0 1 1 1 1 Streptococcal surface antigen repeat Histone_H2A_C PF16211.5 KOO35504.1 - 5.4e-20 70.8 0.1 5.4e-20 70.8 0.1 1.8 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 KOO35504.1 - 8.9e-14 52.0 0.0 1.2e-13 51.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOO35504.1 - 7.9e-07 29.3 0.0 1.1e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DSRB PF10781.9 KOO35505.1 - 8.4e-06 25.3 0.2 17 5.1 0.0 5.1 5 0 0 5 5 5 2 Dextransucrase DSRB Neuropep_like PF15161.6 KOO35505.1 - 1.1e-05 25.0 1.7 9.5 6.0 0.0 5.1 5 0 0 5 5 5 3 Neuropeptide-like Cul7 PF11515.8 KOO35505.1 - 0.041 14.2 4.6 4.1 7.8 0.1 3.6 2 1 2 4 4 4 0 Mouse development and cellular proliferation protein Cullin-7 DNase_NucA_NucB PF14040.6 KOO35505.1 - 0.63 10.4 6.4 2.8 8.3 0.2 3.1 2 1 1 3 3 3 0 Deoxyribonuclease NucA/NucB VCBS PF13517.6 KOO35506.1 - 1e-115 378.3 132.0 4.8e-14 52.7 5.5 12.1 2 2 10 12 12 12 12 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO35506.1 - 1.6e-54 181.6 123.2 5.8e-05 23.1 1.3 13.5 13 0 0 13 13 13 12 FG-GAP repeat Dockerin_1 PF00404.18 KOO35506.1 - 5.4e-11 42.5 34.0 10 6.4 0.0 12.1 12 0 0 12 12 12 4 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO35506.1 - 2.9e-10 39.8 51.5 1.2 8.5 0.1 12.0 3 3 8 12 12 12 9 Insecticide toxin TcdB middle/N-terminal region BBS1 PF14779.6 KOO35506.1 - 1.2e-09 38.0 2.0 1.1 8.7 0.0 9.4 11 0 0 11 11 11 1 Ciliary BBSome complex subunit 1 TM_PBP2_N PF16296.5 KOO35506.1 - 4e-08 33.3 0.0 14 5.8 0.0 8.2 8 0 0 8 8 8 1 N-terminal of TM subunit in PBP-dependent ABC transporters HET-s_218-289 PF11558.8 KOO35506.1 - 1.2e-07 31.7 0.2 45 4.2 0.1 9.3 11 0 0 11 11 11 0 Het-s 218-289 EF-hand_1 PF00036.32 KOO35506.1 - 0.019 14.5 56.7 11 5.8 0.3 12.2 12 0 0 12 12 12 0 EF hand EF-hand_5 PF13202.6 KOO35506.1 - 1.2 8.8 84.0 5.8 6.6 1.2 12.8 12 0 0 12 12 12 0 EF hand NCD3G PF07562.14 KOO35506.1 - 4.9 7.2 8.2 1 9.4 1.0 2.3 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR TPR_2 PF07719.17 KOO35507.1 - 0.00061 19.7 10.3 0.01 15.9 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO35507.1 - 0.0011 19.0 1.7 0.0016 18.5 0.2 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO35507.1 - 0.032 14.4 0.3 12 6.4 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5113 PF17140.4 KOO35507.1 - 0.13 12.0 0.4 0.23 11.2 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) TPR_16 PF13432.6 KOO35507.1 - 3.1 8.5 12.2 0.13 12.9 1.6 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO35507.1 - 4.6 7.0 7.2 0.94 9.2 0.4 2.7 2 0 0 2 2 2 0 TPR repeat Pkinase PF00069.25 KOO35508.1 - 1.1e-33 116.8 0.0 1.3e-33 116.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35508.1 - 2.9e-26 92.3 0.0 5.1e-26 91.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO35508.1 - 7.1e-07 28.3 0.0 9.7e-07 27.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO35508.1 - 0.0006 19.2 0.0 0.00078 18.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO35508.1 - 0.086 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PTPS PF01242.19 KOO35509.1 - 0.0023 17.9 0.0 0.0024 17.8 0.0 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase EF-hand_1 PF00036.32 KOO35510.1 - 1.1e-08 34.0 0.0 0.0039 16.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO35510.1 - 2.7e-08 33.1 0.0 0.0047 16.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain Myb_DNA-bind_6 PF13921.6 KOO35510.1 - 4.6e-07 30.0 0.1 1.4e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain EF-hand_5 PF13202.6 KOO35510.1 - 1.1e-06 27.9 0.0 0.068 12.7 0.0 2.6 2 0 0 2 2 2 2 EF hand Myb_DNA-binding PF00249.31 KOO35510.1 - 1.4e-06 28.4 0.1 5.6e-06 26.4 0.1 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain EF-hand_7 PF13499.6 KOO35510.1 - 1.2e-05 25.6 0.0 4e-05 24.0 0.0 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO35510.1 - 3.1e-05 23.7 0.0 0.00027 20.7 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair Myb_DNA-bind_4 PF13837.6 KOO35510.1 - 0.00051 20.4 0.0 0.0032 17.8 0.1 2.2 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain DUF1127 PF06568.11 KOO35510.1 - 0.022 14.5 0.0 0.095 12.4 0.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) HHH_8 PF14716.6 KOO35512.1 - 0.00059 20.2 0.4 0.0009 19.6 0.3 1.4 1 1 0 1 1 1 1 Helix-hairpin-helix domain DUF2937 PF11157.8 KOO35512.1 - 0.0013 18.4 0.9 0.0021 17.8 0.8 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2937) ZapB PF06005.12 KOO35512.1 - 0.011 16.2 3.0 0.013 16.0 2.9 1.2 1 1 0 1 1 1 0 Cell division protein ZapB Rbsn PF11464.8 KOO35512.1 - 0.04 13.7 2.2 1.9 8.3 0.1 3.1 2 1 1 3 3 3 0 Rabenosyn Rab binding domain OTU PF02338.19 KOO35513.1 - 8.5e-05 23.0 0.0 0.00019 21.9 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease DUF3024 PF11225.8 KOO35513.1 - 0.12 12.6 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) SWIRM-assoc_2 PF16496.5 KOO35513.1 - 5.3 5.8 18.1 7.5 5.3 18.1 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal EF-hand_6 PF13405.6 KOO35514.1 - 3.8e-13 48.2 2.2 2.1e-05 24.1 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO35514.1 - 1.1e-12 46.5 2.3 8.1e-06 25.0 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO35514.1 - 3e-11 43.6 0.0 6.9e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO35514.1 - 2.1e-09 37.0 0.2 3e-07 30.2 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO35514.1 - 6.1e-07 28.6 2.7 0.00026 20.3 0.1 2.5 2 0 0 2 2 2 2 EF hand SAM_Exu PF18609.1 KOO35514.1 - 0.016 15.2 0.1 2.6 8.2 0.0 2.9 2 0 0 2 2 2 0 Exuperantia SAM-like domain PHY PF00360.20 KOO35514.1 - 0.019 14.3 0.0 0.037 13.3 0.0 1.5 1 1 0 1 1 1 0 Phytochrome region Reovirus_L2 PF06016.11 KOO35514.1 - 0.04 11.2 0.0 0.047 10.9 0.0 1.0 1 0 0 1 1 1 0 Reovirus core-spike protein lambda-2 (L2) DUF4365 PF14280.6 KOO35514.1 - 0.13 12.2 0.0 0.66 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4365) Beta_protein PF14350.6 KOO35514.1 - 0.17 11.2 1.7 11 5.3 0.5 2.1 2 0 0 2 2 2 0 Beta protein Rxt3 PF08642.10 KOO35515.1 - 0.079 13.7 0.0 0.11 13.2 0.0 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Nup84_Nup100 PF04121.13 KOO35516.1 - 6.1e-60 203.2 1.7 7.9e-45 153.2 4.2 3.5 3 1 0 3 3 3 2 Nuclear pore protein 84 / 107 TIR_2 PF13676.6 KOO35517.1 - 2.8e-10 40.8 0.0 3.9e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 KOO35517.1 - 0.00076 19.3 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.11 KOO35517.1 - 0.0012 19.1 0.0 0.0036 17.6 0.0 1.8 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) Thioredoxin_4 PF13462.6 KOO35517.1 - 0.0024 18.0 0.0 0.0037 17.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin NAD_binding_10 PF13460.6 KOO35517.1 - 0.0059 16.5 0.0 0.0076 16.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding DUF4406 PF14359.6 KOO35517.1 - 0.018 15.5 0.0 0.03 14.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4406) Amnionless PF14828.6 KOO35517.1 - 0.04 12.7 0.0 0.046 12.5 0.0 1.1 1 0 0 1 1 1 0 Amnionless DUF4514 PF14986.6 KOO35517.1 - 0.052 13.5 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) MtrF PF09472.10 KOO35517.1 - 0.27 10.6 4.0 0.51 9.8 4.0 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) RIFIN PF02009.16 KOO35517.1 - 0.45 10.4 2.1 19 5.0 0.0 2.2 2 0 0 2 2 2 0 Rifin AdoHcyase PF05221.17 KOO35518.1 - 2.3e-28 99.2 0.2 2.6e-28 99.1 0.2 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AP2 PF00847.20 KOO35519.1 - 0.00069 19.8 0.1 0.00069 19.8 0.1 3.0 3 0 0 3 3 3 1 AP2 domain CRAL_TRIO PF00650.20 KOO35520.1 - 3.7e-18 65.7 0.0 5e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain E1-N PF14463.6 KOO35520.1 - 0.0018 18.1 0.1 0.0032 17.3 0.1 1.5 1 0 0 1 1 1 1 E1 N-terminal domain SHIPPO-rpt PF07004.12 KOO35521.1 - 8.9e-06 26.4 14.3 3.8 8.6 0.0 5.6 5 0 0 5 5 5 4 Sperm-tail PG-rich repeat TIG PF01833.24 KOO35524.1 - 2.6e-08 33.8 0.0 3.3e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 IPT/TIG domain TIG_plexin PF17960.1 KOO35524.1 - 0.0024 17.8 0.0 0.0033 17.4 0.0 1.3 1 0 0 1 1 1 1 TIG domain TIG PF01833.24 KOO35525.1 - 4.5e-06 26.7 0.7 8.4e-06 25.8 0.2 1.8 2 1 0 2 2 2 1 IPT/TIG domain Methyltransf_16 PF10294.9 KOO35526.1 - 3.9e-16 59.3 0.0 4.7e-14 52.5 0.0 2.2 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 KOO35526.1 - 2e-07 31.0 0.0 4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO35526.1 - 3.6e-05 24.4 0.3 0.00023 21.8 0.3 2.4 1 1 0 1 1 1 1 Methyltransferase domain F-box-like PF12937.7 KOO35526.1 - 0.00033 20.5 0.4 0.0008 19.3 0.4 1.7 1 0 0 1 1 1 1 F-box-like Methyltransf_11 PF08241.12 KOO35526.1 - 0.00089 19.9 0.2 0.0027 18.3 0.2 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO35526.1 - 0.0054 17.4 0.1 0.11 13.2 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO35526.1 - 0.0064 15.9 0.1 0.011 15.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KOO35526.1 - 0.01 15.4 0.1 0.02 14.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.6 KOO35526.1 - 0.011 15.5 0.0 0.024 14.4 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain tRNA_U5-meth_tr PF05958.11 KOO35526.1 - 0.025 13.6 0.0 0.037 13.0 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase TehB PF03848.14 KOO35526.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB DUF4050 PF13259.6 KOO35526.1 - 0.24 11.7 2.5 0.54 10.6 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DREV PF05219.12 KOO35526.1 - 0.25 10.4 0.0 0.41 9.7 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_32 PF13679.6 KOO35526.1 - 0.33 10.9 3.5 0.44 10.5 0.0 2.7 3 1 1 4 4 4 0 Methyltransferase domain Apt1 PF10351.9 KOO35526.1 - 5.8 5.7 5.5 8.2 5.2 5.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PP-binding PF00550.25 KOO35527.1 - 1.6e-09 38.0 0.1 4e-09 36.7 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site SET PF00856.28 KOO35527.1 - 4.7e-09 36.9 1.0 0.00011 22.7 0.0 4.9 3 1 2 5 5 5 2 SET domain EGF_2 PF07974.13 KOO35528.1 - 1.9e-19 69.7 71.9 3.3e-05 24.2 0.6 6.3 6 0 0 6 6 6 5 EGF-like domain EGF_Tenascin PF18720.1 KOO35528.1 - 2.1e-09 37.2 68.2 0.0047 17.0 10.7 6.4 6 0 0 6 6 6 5 Tenascin EGF domain Actin PF00022.19 KOO35528.1 - 1.2e-05 24.1 1.6 0.016 13.9 0.0 3.0 3 0 0 3 3 3 3 Actin hEGF PF12661.7 KOO35528.1 - 0.0074 16.9 5.5 0.0074 16.9 5.5 6.7 6 1 0 6 6 6 1 Human growth factor-like EGF Laminin_EGF PF00053.24 KOO35528.1 - 0.025 14.7 68.9 0.99 9.6 0.7 6.5 2 1 4 6 6 6 0 Laminin EGF domain PAN_1 PF00024.26 KOO35529.1 - 0.0002 21.3 1.0 0.00037 20.4 1.0 1.4 1 0 0 1 1 1 1 PAN domain Sel1 PF08238.12 KOO35530.1 - 2.1e-76 250.6 89.5 4e-07 30.5 0.8 13.2 14 0 0 14 14 14 12 Sel1 repeat TMEM119 PF15724.5 KOO35530.1 - 0.081 13.0 8.8 0.22 11.5 8.8 1.7 1 0 0 1 1 1 0 TMEM119 family Baculo_VP91_N PF08475.10 KOO35530.1 - 0.15 11.7 3.1 45 3.6 0.0 5.0 4 3 2 7 7 7 0 Viral capsid protein 91 N-terminal CSTF2_hinge PF14327.6 KOO35530.1 - 1.1 9.8 3.2 1.8e+02 2.7 0.1 4.2 4 0 0 4 4 4 0 Hinge domain of cleavage stimulation factor subunit 2 TFIIB_C_1 PF18542.1 KOO35530.1 - 4.1 7.5 18.8 18 5.5 0.4 6.8 2 1 7 9 9 9 0 Transcription factor IIB C-terminal module 1 WD40 PF00400.32 KOO35531.1 - 0.00073 20.3 0.1 0.003 18.3 0.1 2.1 1 0 0 1 1 1 1 WD domain, G-beta repeat HEAT PF02985.22 KOO35531.1 - 0.0018 18.4 0.6 2.2 8.7 0.0 3.9 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 KOO35531.1 - 0.25 11.7 6.2 6.8 7.2 0.0 4.0 4 1 0 4 4 4 0 HEAT repeats SOUL PF04832.12 KOO35532.1 - 3.4e-21 76.1 0.0 5.6e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 SOUL heme-binding protein DUF2358 PF10184.9 KOO35532.1 - 1.5e-17 63.9 0.0 3e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) Apolipoprotein PF01442.18 KOO35535.1 - 0.011 15.6 13.0 0.011 15.6 13.0 3.1 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Ribosomal_L31 PF01197.18 KOO35537.1 - 1.2e-06 28.6 0.0 1.3e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L31 Methyltransf_25 PF13649.6 KOO35538.1 - 0.088 13.5 0.0 0.45 11.3 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain DUF3035 PF11233.8 KOO35539.1 - 0.031 14.6 3.3 0.046 14.0 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3035) Pyridoxal_deC PF00282.19 KOO35541.1 - 1.4e-98 330.1 0.0 7.7e-97 324.3 0.0 2.1 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 KOO35541.1 - 0.012 14.9 0.0 0.026 13.7 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KOO35541.1 - 0.15 11.3 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase IQ PF00612.27 KOO35542.1 - 1.4e-05 24.5 0.8 0.027 14.3 0.2 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif DNA_pol_viral_C PF00336.18 KOO35543.1 - 0.12 11.7 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain TetR_C_11 PF16859.5 KOO35544.1 - 0.022 15.1 0.3 0.048 14.0 0.3 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Ntox44 PF15607.6 KOO35544.1 - 0.16 12.3 0.0 0.71 10.2 0.0 2.0 2 0 0 2 2 2 0 Bacterial toxin 44 OTU PF02338.19 KOO35546.1 - 1.6e-06 28.6 0.0 4.1e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 KOO35546.1 - 0.041 13.3 0.3 2.6 7.5 0.1 2.5 1 1 0 2 2 2 0 Peptidase C65 Otubain ABC1 PF03109.16 KOO35547.1 - 2.4e-24 85.8 0.0 3.5e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO35547.1 - 0.012 15.5 6.8 0.069 13.1 6.8 2.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 KOO35547.1 - 0.083 12.2 0.0 0.58 9.5 0.0 2.0 2 0 0 2 2 2 0 Protein kinase domain Pox_ser-thr_kin PF05445.11 KOO35547.1 - 0.29 10.1 0.0 0.4 9.6 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PPR_2 PF13041.6 KOO35548.1 - 6.7e-30 103.0 0.1 5.9e-16 58.4 0.0 2.2 1 1 1 2 2 2 2 PPR repeat family PPR_1 PF12854.7 KOO35548.1 - 2.3e-23 81.6 0.1 8.8e-12 44.5 0.0 3.0 3 0 0 3 3 3 3 PPR repeat PPR PF01535.20 KOO35548.1 - 1.8e-21 74.8 0.0 1.5e-08 34.4 0.0 3.1 3 0 0 3 3 3 3 PPR repeat PPR_3 PF13812.6 KOO35548.1 - 8.2e-15 54.6 0.0 2.6e-13 49.9 0.0 2.1 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO35548.1 - 8.1e-10 38.4 0.7 2e-09 37.1 0.7 1.6 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP MRP-S27 PF10037.9 KOO35548.1 - 0.038 12.9 0.0 0.04 12.8 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 AviRa PF11599.8 KOO35548.1 - 0.14 11.6 0.2 0.16 11.4 0.2 1.1 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Bax1-I PF01027.20 KOO35549.1 - 3.8e-36 124.9 21.7 4.8e-36 124.5 21.7 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Aa_trans PF01490.18 KOO35550.1 - 8.5e-55 186.1 17.7 1.1e-54 185.7 17.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PsaL PF02605.15 KOO35550.1 - 0.46 10.1 3.6 1.5 8.4 0.1 2.8 3 0 0 3 3 3 0 Photosystem I reaction centre subunit XI ETRAMP PF09716.10 KOO35550.1 - 0.58 10.3 0.0 0.58 10.3 0.0 2.6 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) TGFb_propeptide PF00688.18 KOO35551.1 - 0.0018 18.0 0.4 0.023 14.4 0.2 2.3 3 0 0 3 3 3 1 TGF-beta propeptide Upf2 PF04050.14 KOO35552.1 - 0.21 12.3 0.0 0.34 11.6 0.0 1.3 1 0 0 1 1 1 0 Up-frameshift suppressor 2 DUF4364 PF14277.6 KOO35552.1 - 0.21 11.3 0.2 0.3 10.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) CAP_N PF01213.19 KOO35552.1 - 0.67 9.4 3.4 1.1 8.7 3.4 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal NAD_binding_10 PF13460.6 KOO35553.1 - 1.9e-29 102.8 0.1 3.5e-29 102.0 0.1 1.4 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOO35553.1 - 1.9e-20 73.5 0.0 3.4e-20 72.6 0.0 1.3 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 KOO35553.1 - 1.8e-13 50.5 0.1 3.7e-13 49.5 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOO35553.1 - 3.3e-07 29.6 0.0 4.6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 KOO35553.1 - 1.3e-05 25.4 0.3 3.3e-05 24.1 0.3 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 KOO35553.1 - 0.00024 21.5 0.1 0.00042 20.7 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 KOO35553.1 - 0.00046 19.4 0.4 0.00085 18.5 0.4 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 KOO35553.1 - 0.0034 16.9 0.1 0.0052 16.3 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 KOO35553.1 - 0.0035 16.8 0.0 0.0069 15.8 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KOO35553.1 - 0.004 16.4 0.2 0.18 10.9 0.0 2.4 1 1 2 3 3 3 1 Male sterility protein TrkA_N PF02254.18 KOO35553.1 - 0.0041 17.4 0.0 0.0084 16.4 0.0 1.6 1 1 0 1 1 1 1 TrkA-N domain STIL_N PF15253.6 KOO35553.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 SCL-interrupting locus protein N-terminus VPS13_C PF16909.5 KOO35554.1 - 3.3e-23 82.4 0.0 8e-23 81.1 0.0 1.6 1 1 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal MDMPI_N PF11716.8 KOO35554.1 - 0.074 13.7 3.2 2.3 8.9 0.5 2.2 2 0 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain GRAM PF02893.20 KOO35555.1 - 9.7e-12 44.8 0.0 1.6e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 GRAM domain Nucleoside_tran PF01733.18 KOO35556.1 - 2.9e-19 69.6 6.3 4.8e-13 49.2 0.2 3.2 3 0 0 3 3 3 3 Nucleoside transporter Nucleoside_tran PF01733.18 KOO35557.1 - 0.006 16.0 0.8 0.0066 15.9 0.8 1.0 1 0 0 1 1 1 1 Nucleoside transporter MucB_RseB_C PF17188.4 KOO35557.1 - 0.17 12.1 0.0 0.21 11.8 0.0 1.1 1 0 0 1 1 1 0 MucB/RseB C-terminal domain Ank_2 PF12796.7 KOO35558.1 - 1.3e-33 115.4 4.6 1.5e-14 54.3 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO35558.1 - 1.5e-23 82.8 4.8 2.7e-07 31.0 0.6 5.0 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO35558.1 - 2e-22 78.9 9.2 2.8e-06 27.5 0.1 5.2 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO35558.1 - 3.1e-20 71.6 7.9 8.6e-05 22.8 0.0 6.0 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 KOO35558.1 - 1.9e-15 55.4 1.7 0.19 12.4 0.0 5.9 5 0 0 5 5 5 5 Ankyrin repeat PRD1_DD PF11087.8 KOO35558.1 - 0.03 14.0 0.0 0.069 12.8 0.0 1.6 1 0 0 1 1 1 0 PRD1 phage membrane DNA delivery ASH PF15780.5 KOO35561.1 - 1.3e-06 28.5 0.1 0.034 14.3 0.1 4.1 5 0 0 5 5 5 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1654 PF07867.11 KOO35561.1 - 0.024 14.4 0.1 0.024 14.4 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1654) SpmSyn_N PF17950.1 KOO35561.1 - 0.051 13.8 0.1 0.59 10.3 0.0 2.3 2 0 0 2 2 2 0 S-adenosylmethionine decarboxylase N -terminal TMEM131_like PF12371.8 KOO35561.1 - 0.099 12.9 0.7 24 5.3 1.0 3.8 4 1 1 5 5 5 0 Transmembrane protein 131-like Methyltransf_23 PF13489.6 KOO35562.1 - 1.4e-17 64.0 0.0 1.8e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO35562.1 - 1.5e-12 48.0 0.0 3e-12 47.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO35562.1 - 6.2e-09 36.5 0.0 1.4e-08 35.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO35562.1 - 2.9e-08 34.3 0.0 8.5e-08 32.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO35562.1 - 3.1e-07 30.3 0.0 1.7e-05 24.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 KOO35562.1 - 3.1e-07 29.8 0.0 4.5e-07 29.2 0.0 1.3 1 1 0 1 1 1 1 DREV methyltransferase Methyltransf_9 PF08003.11 KOO35562.1 - 0.00051 19.1 0.0 0.00066 18.7 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 KOO35562.1 - 0.0024 17.3 0.0 0.07 12.4 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 KOO35562.1 - 0.012 15.3 0.0 3.4 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 KOO35562.1 - 0.053 13.1 0.0 0.13 11.9 0.0 1.7 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.14 KOO35562.1 - 0.2 11.2 0.0 0.35 10.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Orbi_VP6 PF01516.16 KOO35562.1 - 0.23 11.0 0.0 0.28 10.7 0.0 1.1 1 0 0 1 1 1 0 Orbivirus helicase VP6 Aminotran_1_2 PF00155.21 KOO35563.1 - 7.2e-20 71.5 0.0 7.9e-20 71.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II NUDIX PF00293.28 KOO35564.1 - 6.6e-09 35.9 0.0 1.1e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Pro_isomerase PF00160.21 KOO35565.1 - 1.3e-45 155.5 0.3 1.5e-45 155.3 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Topoisom_bac PF01131.20 KOO35566.1 - 7.2e-107 357.9 0.0 9.2e-107 357.6 0.0 1.0 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 KOO35566.1 - 9.3e-12 45.1 0.0 2.3e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Toprim domain Mago_nashi PF02792.14 KOO35567.1 - 1.4e-70 236.0 0.1 1.8e-70 235.6 0.1 1.2 1 0 0 1 1 1 1 Mago nashi protein Recombinase PF07508.13 KOO35567.1 - 0.065 13.6 0.1 0.096 13.1 0.1 1.2 1 0 0 1 1 1 0 Recombinase PhoLip_ATPase_C PF16212.5 KOO35568.1 - 1.9e-49 168.7 10.2 2.5e-49 168.3 10.2 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 KOO35568.1 - 7.1e-12 45.3 0.0 9e-09 35.3 0.0 2.4 2 0 0 2 2 2 2 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOO35568.1 - 7.5e-10 39.4 0.1 0.0013 19.1 0.1 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOO35568.1 - 0.023 14.4 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4392 PF14336.6 KOO35568.1 - 0.12 11.7 0.1 0.25 10.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) EF-hand_6 PF13405.6 KOO35569.1 - 2.8e-35 117.2 14.8 6.4e-07 28.8 0.6 7.4 7 0 0 7 7 7 6 EF-hand domain EF-hand_1 PF00036.32 KOO35569.1 - 1.2e-28 96.4 24.6 2.4e-06 26.7 0.7 7.3 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.6 KOO35569.1 - 1.2e-25 89.7 18.3 2.5e-09 37.4 0.9 4.0 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 KOO35569.1 - 9.6e-18 63.8 18.3 2.1e-07 30.6 0.2 5.7 5 1 1 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO35569.1 - 2.9e-14 51.8 25.2 0.00042 19.7 1.2 6.6 6 0 0 6 6 6 4 EF hand EF-hand_9 PF14658.6 KOO35569.1 - 0.00096 19.4 0.5 52 4.3 0.0 4.5 5 0 0 5 5 5 0 EF-hand domain TerB PF05099.13 KOO35569.1 - 0.0028 17.6 0.8 1.4 8.8 0.1 2.8 3 0 0 3 3 3 2 Tellurite resistance protein TerB SPARC_Ca_bdg PF10591.9 KOO35569.1 - 0.0038 17.5 4.1 1.9 8.9 0.1 3.9 2 2 2 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.12 KOO35569.1 - 0.013 15.7 0.1 7.3 6.7 0.0 2.3 2 0 0 2 2 2 0 p25-alpha Sulfotransfer_3 PF13469.6 KOO35569.1 - 0.073 13.4 0.6 0.26 11.7 0.6 1.9 1 0 0 1 1 1 0 Sulfotransferase family Caleosin PF05042.13 KOO35569.1 - 0.13 12.2 1.9 17 5.3 0.1 3.8 3 3 2 5 5 5 0 Caleosin related protein cNMP_binding PF00027.29 KOO35570.1 - 3.3e-20 71.9 0.1 7.6e-20 70.8 0.1 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Cpn60_TCP1 PF00118.24 KOO35571.1 - 7.4e-14 51.2 0.0 4.4e-13 48.7 0.0 1.8 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Acyl_transf_3 PF01757.22 KOO35572.1 - 0.0062 15.7 2.0 0.0065 15.6 2.0 1.1 1 0 0 1 1 1 1 Acyltransferase family PhoLip_ATPase_N PF16209.5 KOO35573.1 - 2.2e-17 62.5 2.3 3.8e-17 61.7 2.3 1.4 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 KOO35573.1 - 7.7e-10 38.6 0.0 3.5e-09 36.4 0.0 2.0 2 1 0 2 2 2 1 E1-E2 ATPase CYSTM PF12734.7 KOO35573.1 - 0.019 15.3 2.7 0.042 14.2 2.7 1.6 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance Ycf9 PF01737.17 KOO35573.1 - 0.049 13.5 0.1 0.16 11.9 0.1 1.9 1 0 0 1 1 1 0 YCF9 AAA PF00004.29 KOO35574.1 - 3.4e-11 43.7 0.0 5.1e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOO35574.1 - 4.3e-06 26.6 0.8 6.4e-06 26.0 0.4 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOO35574.1 - 2.2e-05 24.9 0.0 5.2e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KOO35574.1 - 0.00018 21.6 0.0 0.00025 21.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KOO35574.1 - 0.0002 20.9 0.1 0.00028 20.4 0.1 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 KOO35574.1 - 0.00029 21.1 0.0 0.00087 19.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_6 PF12774.7 KOO35574.1 - 0.00067 18.7 0.0 0.00092 18.3 0.0 1.1 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region Zeta_toxin PF06414.12 KOO35574.1 - 0.0012 18.2 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Rad17 PF03215.15 KOO35574.1 - 0.0017 18.3 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 KOO35574.1 - 0.0017 18.1 0.0 0.0025 17.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KOO35574.1 - 0.0024 18.4 0.0 0.0037 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOO35574.1 - 0.0026 17.6 0.0 0.0033 17.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO35574.1 - 0.0042 17.2 0.0 0.0067 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOO35574.1 - 0.0098 16.3 0.0 0.016 15.6 0.0 1.6 1 1 0 1 1 1 1 RNA helicase AAA_19 PF13245.6 KOO35574.1 - 0.012 15.9 0.3 0.1 12.9 0.3 2.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOO35574.1 - 0.014 15.6 0.1 0.022 15.0 0.0 1.4 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.6 KOO35574.1 - 0.016 15.3 0.0 0.024 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KOO35574.1 - 0.034 13.5 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 KOO35574.1 - 0.035 14.0 0.0 0.14 12.0 0.0 1.8 1 1 1 2 2 2 0 NTPase TsaE PF02367.17 KOO35574.1 - 0.041 13.9 0.0 0.063 13.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 KOO35574.1 - 0.051 13.5 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_17 PF13207.6 KOO35574.1 - 0.061 13.8 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOO35574.1 - 0.11 11.6 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.6 KOO35574.1 - 0.13 12.0 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain RFC1 PF08519.12 KOO35575.1 - 1.7e-19 70.5 0.0 2.4e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain Ribosomal_L14e PF01929.17 KOO35576.1 - 2e-22 79.5 2.8 2.5e-22 79.1 2.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 KOO35576.1 - 0.0014 18.5 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 KOW motif TIM PF00121.18 KOO35577.1 - 1.3e-68 231.0 0.0 1.5e-68 230.8 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase GP17 PF17420.2 KOO35577.1 - 0.12 12.6 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Superinfection exclusion gene product 17 TPR_12 PF13424.6 KOO35578.1 - 2e-08 34.4 0.6 2.7e-07 30.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO35578.1 - 4.2e-06 26.4 0.8 0.039 13.8 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO35578.1 - 7.1e-06 25.7 7.7 0.013 15.6 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO35578.1 - 2.6e-05 23.9 0.1 1.7 8.9 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO35578.1 - 0.00034 20.3 5.7 0.0036 17.0 0.3 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat SPO22 PF08631.10 KOO35578.1 - 0.022 14.3 1.3 0.31 10.5 0.5 2.2 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 KOO35578.1 - 0.027 14.5 3.1 0.79 9.8 0.4 2.7 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 KOO35578.1 - 0.049 13.9 1.6 0.077 13.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO35578.1 - 0.054 14.0 0.8 24 5.5 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO35578.1 - 0.081 13.8 1.5 31 5.8 0.7 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4924 PF16271.5 KOO35578.1 - 0.098 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) WD40 PF00400.32 KOO35579.1 - 4.5e-50 166.5 16.6 2.3e-09 37.7 0.3 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO35579.1 - 7.1e-15 54.8 2.8 0.097 11.6 0.0 5.0 2 1 3 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO35579.1 - 1.6e-12 47.0 0.7 1.1 9.3 0.0 5.4 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 KOO35579.1 - 6.1e-12 45.7 1.5 0.078 13.3 0.1 5.1 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO35579.1 - 3.2e-07 30.4 0.1 0.0011 18.9 0.0 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 KOO35579.1 - 3.5e-07 29.0 0.0 0.057 11.7 0.0 4.3 2 1 3 5 5 5 4 WD repeat-containing and planar cell polarity effector protein Fritz BBS2_Mid PF14783.6 KOO35579.1 - 2e-05 24.6 0.1 4.9 7.2 0.0 4.7 2 1 3 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 KOO35579.1 - 0.00011 21.7 6.1 5.1 6.3 0.1 4.7 2 1 3 5 5 5 4 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 KOO35579.1 - 0.00077 18.9 0.1 0.95 8.7 0.0 3.5 2 1 1 4 4 4 1 WD40-like domain DCX PF03607.17 KOO35579.1 - 0.0036 17.4 0.0 18 5.5 0.0 4.7 5 0 0 5 5 5 0 Doublecortin Viral_Beta_CD PF04530.12 KOO35579.1 - 0.0071 16.6 0.2 51 4.2 0.0 3.9 2 1 2 4 4 4 0 Viral Beta C/D like family WD40_3 PF15911.5 KOO35579.1 - 0.0077 16.2 0.2 20 5.3 0.0 4.5 5 0 0 5 5 5 0 WD domain, G-beta repeat Dfp1_Him1_M PF08630.10 KOO35579.1 - 0.028 14.6 4.0 22 5.3 0.0 4.1 4 0 0 4 4 4 0 Dfp1/Him1, central region Proteasome_A_N PF10584.9 KOO35579.1 - 3.9 7.3 13.6 1.1e+02 2.6 0.1 5.7 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature ubiquitin PF00240.23 KOO35580.1 - 1.1e-17 63.5 0.0 1.9e-09 37.2 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 KOO35580.1 - 3.7e-05 23.5 0.0 0.006 16.4 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KOO35580.1 - 0.0026 18.2 0.0 0.076 13.5 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-like domain BPL_LplA_LipB_2 PF16917.5 KOO35580.1 - 0.011 15.2 1.1 0.38 10.2 0.0 2.5 2 0 0 2 2 2 0 Biotin/lipoate A/B protein ligase family Myb_DNA-binding PF00249.31 KOO35582.1 - 2.4e-20 72.5 1.1 4.1e-10 39.7 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO35582.1 - 6e-10 39.2 0.2 1.6e-05 25.0 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 KOO35582.1 - 0.00017 21.6 1.7 0.084 13.0 0.1 2.5 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 KOO35582.1 - 0.0095 16.1 0.0 4.3 7.6 0.0 2.3 2 0 0 2 2 2 2 SANT/Myb-like domain of DAMP1 DUF3606 PF12244.8 KOO35582.1 - 0.032 14.1 0.2 2.1 8.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) zf-C2H2 PF00096.26 KOO35582.1 - 1.1 9.8 5.3 2.8 8.6 0.1 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type PDZ PF00595.24 KOO35585.1 - 3.2e-22 78.7 1.3 2.7e-06 27.6 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KOO35585.1 - 9.9e-22 76.6 8.8 1e-10 41.3 1.2 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KOO35585.1 - 2e-21 76.1 1.1 8.5e-07 29.2 0.0 3.4 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.6 KOO35585.1 - 0.00018 21.4 0.4 1.3 9.1 0.0 3.2 3 0 0 3 3 3 2 Tricorn protease PDZ domain Kinetochor_Ybp2 PF08568.10 KOO35586.1 - 3.5e-09 35.7 0.0 5.3e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin SKA2 PF16740.5 KOO35587.1 - 0.055 13.3 0.4 0.079 12.7 0.4 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 K-box PF01486.17 KOO35587.1 - 0.076 13.2 1.2 0.12 12.6 1.2 1.2 1 0 0 1 1 1 0 K-box region Cytochrom_B562 PF07361.11 KOO35588.1 - 0.0079 16.8 0.2 0.011 16.3 0.2 1.4 1 0 0 1 1 1 1 Cytochrome b562 TBCC_N PF16752.5 KOO35588.1 - 0.0084 16.5 0.1 0.011 16.2 0.1 1.3 1 1 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain DUF5344 PF17279.2 KOO35588.1 - 0.011 16.3 0.2 0.022 15.4 0.1 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5344) EzrA PF06160.12 KOO35588.1 - 0.011 13.9 0.6 0.013 13.7 0.6 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA PAS_3 PF08447.12 KOO35588.1 - 0.02 15.2 0.1 0.59 10.5 0.1 2.0 2 0 0 2 2 2 0 PAS fold Apolipoprotein PF01442.18 KOO35588.1 - 0.025 14.5 4.4 0.085 12.7 4.4 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain LUD_dom PF02589.15 KOO35588.1 - 0.045 13.5 0.1 0.059 13.1 0.1 1.3 1 1 0 1 1 1 0 LUD domain DUF4315 PF14193.6 KOO35588.1 - 0.05 13.6 0.3 0.05 13.6 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) TRCF PF03461.15 KOO35588.1 - 0.055 13.9 0.5 0.27 11.7 0.1 1.9 2 0 0 2 2 2 0 TRCF domain DUF1825 PF08855.10 KOO35588.1 - 0.089 12.7 0.8 0.15 12.0 0.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1825) MDMPI_N PF11716.8 KOO35588.1 - 0.11 13.1 0.1 0.12 13.0 0.1 1.2 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain HSCB_C PF07743.13 KOO35588.1 - 0.13 12.8 4.0 0.39 11.2 0.8 2.1 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain Latarcin PF10279.9 KOO35588.1 - 0.27 11.7 3.2 0.57 10.6 1.0 2.2 1 1 1 2 2 2 0 Latarcin precursor Na_H_antiport_2 PF13726.6 KOO35589.1 - 0.11 12.6 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Na+-H+ antiporter family RabGAP-TBC PF00566.18 KOO35590.1 - 2.8e-40 138.3 0.0 2e-39 135.5 0.0 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PDZ PF00595.24 KOO35590.1 - 0.18 12.2 0.0 0.34 11.3 0.0 1.5 1 0 0 1 1 1 0 PDZ domain KIAA1430 PF13879.6 KOO35591.1 - 2e-07 31.7 6.0 2.5e-05 25.0 1.5 2.3 1 1 1 2 2 2 2 KIAA1430 homologue DUF3138 PF11336.8 KOO35591.1 - 0.03 13.0 28.3 0.011 14.3 11.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) FlaC_arch PF05377.11 KOO35591.1 - 0.1 13.0 1.6 9.8 6.7 0.1 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 KOO35591.1 - 0.15 12.7 2.6 7.3 7.3 0.2 3.0 3 0 0 3 3 3 0 SlyX YabA PF06156.13 KOO35591.1 - 0.61 10.8 6.1 3.1 8.5 0.7 3.0 1 1 1 2 2 2 0 Initiation control protein YabA NYD-SP28_assoc PF14775.6 KOO35591.1 - 0.61 10.2 4.8 11 6.3 0.4 2.9 3 0 0 3 3 3 0 Sperm tail C-terminal domain DivIC PF04977.15 KOO35591.1 - 0.85 9.4 21.9 0.28 11.0 2.3 3.9 2 1 2 4 4 4 0 Septum formation initiator Ca_chan_IQ PF08763.11 KOO35591.1 - 1.5 9.1 8.0 10 6.4 0.2 3.3 1 1 2 3 3 3 0 Voltage gated calcium channel IQ domain ZapB PF06005.12 KOO35591.1 - 5.4 7.5 12.2 3.4 8.2 6.7 3.1 2 1 1 3 3 3 0 Cell division protein ZapB Sigma70_ner PF04546.13 KOO35592.1 - 0.051 13.5 2.8 0.068 13.0 2.8 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region HDV_ag PF01517.18 KOO35592.1 - 0.14 12.0 1.1 0.18 11.6 0.5 1.5 1 1 0 1 1 1 0 Hepatitis delta virus delta antigen PBP1_TM PF14812.6 KOO35592.1 - 0.46 10.9 4.5 0.59 10.5 4.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PBP1_TM PF14812.6 KOO35593.1 - 0.013 15.9 0.8 0.036 14.4 0.2 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TLP-20 PF06088.11 KOO35593.1 - 0.043 13.7 0.4 0.085 12.7 0.4 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RXT2_N PF08595.11 KOO35593.1 - 0.047 13.7 1.2 0.096 12.7 1.2 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF5442 PF17514.2 KOO35593.1 - 0.049 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5442) Retinal PF15449.6 KOO35593.1 - 0.27 9.0 1.0 0.3 8.8 1.0 1.0 1 0 0 1 1 1 0 Retinal protein DUF4611 PF15387.6 KOO35593.1 - 2.8 8.2 9.6 1.1 9.5 6.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) U3_snoRNA_assoc PF08297.11 KOO35593.1 - 3 8.6 6.2 16 6.3 0.1 2.4 2 0 0 2 2 2 0 U3 snoRNA associated DUF2528 PF10800.8 KOO35594.1 - 0.061 13.9 3.4 0.84 10.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2528) DUF1263 PF06882.12 KOO35594.1 - 0.12 12.4 0.1 0.35 11.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1263) MbeB_N PF04837.12 KOO35594.1 - 2.7 8.3 7.5 13 6.2 0.2 2.9 2 1 1 3 3 3 0 MbeB-like, N-term conserved region XAP5 PF04921.14 KOO35594.1 - 4.5 7.0 9.6 2 8.2 2.6 2.1 2 0 0 2 2 2 0 XAP5, circadian clock regulator ATPgrasp_N PF18130.1 KOO35596.1 - 0.0066 17.0 0.0 0.013 16.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp N-terminal domain ADH_zinc_N PF00107.26 KOO35596.1 - 0.09 12.8 0.0 0.25 11.3 0.0 1.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase O-FucT PF10250.9 KOO35597.1 - 6.6e-09 35.9 0.2 1.4e-05 24.9 0.1 2.4 1 1 1 2 2 2 2 GDP-fucose protein O-fucosyltransferase Cation_efflux PF01545.21 KOO35598.1 - 2.6e-49 167.7 0.1 3.8e-49 167.1 0.1 1.2 1 0 0 1 1 1 1 Cation efflux family GtrA PF04138.14 KOO35598.1 - 0.01 16.0 1.0 0.01 16.0 1.0 2.2 2 0 0 2 2 2 0 GtrA-like protein Zip PF02535.22 KOO35598.1 - 2.9 7.0 29.2 41 3.2 29.2 2.2 1 1 0 1 1 1 0 ZIP Zinc transporter EF-hand_6 PF13405.6 KOO35599.1 - 7e-16 56.7 0.1 0.0099 15.7 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO35599.1 - 1.4e-15 55.6 0.1 0.001 18.5 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KOO35599.1 - 3.2e-15 56.3 0.0 5e-06 26.9 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO35599.1 - 1.6e-11 43.9 1.2 0.0026 17.6 0.0 3.9 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO35599.1 - 2e-10 39.7 0.6 0.026 14.0 0.1 3.9 3 1 0 3 3 3 3 EF hand Guanylate_cyc PF00211.20 KOO35599.1 - 0.00081 19.1 0.0 0.13 11.9 0.0 2.8 2 1 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain EF-hand_4 PF12763.7 KOO35599.1 - 0.0031 17.4 0.1 0.018 15.0 0.0 2.2 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand GTP_EFTU PF00009.27 KOO35600.1 - 5.6e-50 169.6 0.0 8.5e-50 169.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RF3_C PF16658.5 KOO35600.1 - 1.9e-37 128.0 0.0 3.1e-37 127.3 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 KOO35600.1 - 6.1e-06 26.3 0.0 1.1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 KOO35600.1 - 0.00034 20.9 0.0 0.00078 19.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KOO35600.1 - 0.00095 19.2 0.0 0.0018 18.4 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.10 KOO35600.1 - 0.19 11.1 0.1 0.98 8.8 0.1 2.1 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit WD40 PF00400.32 KOO35601.1 - 1.7e-10 41.3 1.7 4e-05 24.3 0.1 4.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO35601.1 - 1.2e-07 31.9 0.0 0.0071 16.6 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.22 KOO35602.1 - 3.8e-15 55.4 0.0 3.5e-08 33.1 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KOO35602.1 - 0.022 14.8 0.0 2.1 8.4 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif EarP PF10093.9 KOO35602.1 - 0.095 11.8 0.1 2.1 7.4 0.0 2.0 2 0 0 2 2 2 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP CS PF04969.16 KOO35603.1 - 0.0022 19.0 0.0 0.0041 18.1 0.0 1.3 1 0 0 1 1 1 1 CS domain RRM_1 PF00076.22 KOO35606.1 - 0.0028 17.4 0.0 0.0042 16.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIS_M PF07500.14 KOO35607.1 - 8.3e-10 39.1 0.2 1.2e-09 38.7 0.2 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain AAA PF00004.29 KOO35611.1 - 1e-20 74.5 0.0 1.8e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO35611.1 - 4.9e-05 23.8 0.0 0.00012 22.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KOO35611.1 - 6.8e-05 22.9 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KOO35611.1 - 0.00012 22.6 0.0 0.0014 19.2 0.0 2.1 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 KOO35611.1 - 0.00012 21.3 0.0 0.00015 21.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 KOO35611.1 - 0.00027 21.5 0.0 0.00055 20.5 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 KOO35611.1 - 0.0025 17.4 0.0 0.0085 15.6 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region RuvB_N PF05496.12 KOO35611.1 - 0.0027 17.5 0.0 0.005 16.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 KOO35611.1 - 0.0027 17.3 0.0 0.0099 15.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 KOO35611.1 - 0.0046 16.9 0.0 0.0078 16.2 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain Cytidylate_kin PF02224.18 KOO35611.1 - 0.0087 15.8 0.0 0.014 15.2 0.0 1.5 1 1 0 1 1 1 1 Cytidylate kinase AAA_22 PF13401.6 KOO35611.1 - 0.011 16.1 0.0 0.036 14.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KOO35611.1 - 0.012 15.5 0.0 0.16 11.9 0.0 2.2 1 1 1 2 2 2 0 NACHT domain SAP30_Sin3_bdg PF13867.6 KOO35611.1 - 0.013 15.8 0.0 0.13 12.6 0.0 2.4 3 0 0 3 3 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 RsgA_GTPase PF03193.16 KOO35611.1 - 0.016 15.1 0.0 0.06 13.3 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase ATPase_2 PF01637.18 KOO35611.1 - 0.016 15.1 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 KOO35611.1 - 0.017 15.5 0.0 0.035 14.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 KOO35611.1 - 0.022 15.0 0.0 0.058 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 KOO35611.1 - 0.025 14.3 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 KOO35611.1 - 0.029 14.1 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 KOO35611.1 - 0.06 13.9 0.0 0.14 12.6 0.0 1.5 2 0 0 2 2 1 0 AAA domain AAA_11 PF13086.6 KOO35611.1 - 0.07 12.9 0.0 0.15 11.8 0.0 1.5 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.15 KOO35611.1 - 0.082 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_33 PF13671.6 KOO35611.1 - 0.086 13.0 0.0 0.22 11.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KOO35611.1 - 0.09 12.2 0.0 0.21 10.9 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Herpes_Helicase PF02689.14 KOO35611.1 - 0.1 10.5 0.0 0.15 10.0 0.0 1.2 1 0 0 1 1 1 0 Helicase tRNA_int_endo PF01974.17 KOO35611.1 - 0.11 12.5 0.0 0.35 11.0 0.0 1.8 2 0 0 2 2 1 0 tRNA intron endonuclease, catalytic C-terminal domain ATPase PF06745.13 KOO35611.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_21 PF13304.6 KOO35611.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 KOO35611.1 - 0.16 12.1 0.0 0.45 10.6 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase PPV_E1_C PF00519.17 KOO35611.1 - 0.17 10.7 0.0 0.33 9.7 0.0 1.4 1 1 0 1 1 1 0 Papillomavirus helicase AAA_24 PF13479.6 KOO35611.1 - 0.18 11.5 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain PseudoU_synth_2 PF00849.22 KOO35612.1 - 7.4e-25 87.9 0.1 1.1e-24 87.4 0.1 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Ion_trans PF00520.31 KOO35613.1 - 8e-12 44.9 2.4 1.1e-11 44.4 2.4 1.1 1 0 0 1 1 1 1 Ion transport protein NUC205 PF08168.11 KOO35613.1 - 0.14 11.7 1.6 2.8 7.5 1.3 2.6 2 0 0 2 2 2 0 NUC205 domain PKD_channel PF08016.12 KOO35613.1 - 0.2 10.3 10.7 0.095 11.4 1.2 2.1 2 0 0 2 2 2 0 Polycystin cation channel MORN PF02493.20 KOO35614.1 - 6.5e-10 38.3 0.5 8.7e-05 22.2 0.0 3.1 3 0 0 3 3 3 2 MORN repeat C2 PF00168.30 KOO35615.1 - 6.1e-11 42.5 0.0 1.2e-09 38.3 0.0 2.2 2 0 0 2 2 2 1 C2 domain Fimbrial_PilY2 PF14481.6 KOO35615.1 - 0.053 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Type 4 fimbrial biogenesis protein PilY2 MAS20 PF02064.15 KOO35615.1 - 0.18 11.9 4.2 0.26 11.4 4.2 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor DAGK_acc PF00609.19 KOO35616.1 - 4.9e-13 49.7 0.0 9e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain Defensin_1 PF00323.19 KOO35618.1 - 0.041 14.4 0.1 0.079 13.5 0.1 1.4 1 0 0 1 1 1 0 Mammalian defensin DAGK_cat PF00781.24 KOO35619.1 - 7.8e-26 90.2 0.1 1.6e-25 89.2 0.1 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DAGK_acc PF00609.19 KOO35619.1 - 1.1e-25 90.8 0.0 2.9e-23 83.0 0.0 2.2 2 0 0 2 2 2 2 Diacylglycerol kinase accessory domain Cu PF17563.2 KOO35619.1 - 5.6 7.3 6.1 2 8.7 3.1 1.8 2 0 0 2 2 2 0 Cupiennin Ferlin_C PF16165.5 KOO35620.1 - 6.6e-06 26.1 0.0 1.1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Ferlin C-terminus C2 PF00168.30 KOO35620.1 - 0.0022 18.2 0.0 0.0072 16.6 0.0 1.8 1 1 1 2 2 2 1 C2 domain bZIP_1 PF00170.21 KOO35622.1 - 0.0047 17.0 0.2 0.0047 17.0 0.2 3.5 4 0 0 4 4 4 1 bZIP transcription factor GAS PF13851.6 KOO35622.1 - 1.6 8.0 29.8 0.72 9.2 18.1 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2383 PF09537.10 KOO35622.1 - 6.7 7.1 18.0 2.3 8.6 2.3 4.2 1 1 3 4 4 4 0 Domain of unknown function (DUF2383) TRAM_LAG1_CLN8 PF03798.16 KOO35623.1 - 2e-11 44.0 8.4 3e-11 43.5 8.4 1.2 1 0 0 1 1 1 1 TLC domain PRKG1_interact PF15898.5 KOO35624.1 - 0.0097 16.8 0.7 0.038 14.9 0.3 1.9 2 0 0 2 2 2 1 cGMP-dependent protein kinase interacting domain PKcGMP_CC PF16808.5 KOO35624.1 - 0.01 15.6 0.2 0.027 14.3 0.2 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Nup54 PF13874.6 KOO35624.1 - 0.099 12.7 2.6 0.2 11.7 2.6 1.6 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 GAS PF13851.6 KOO35624.1 - 0.11 11.9 1.5 4.2 6.7 0.4 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Tropomyosin PF00261.20 KOO35624.1 - 0.11 11.8 2.7 0.8 9.0 1.6 2.0 2 0 0 2 2 2 0 Tropomyosin DUF465 PF04325.13 KOO35624.1 - 0.13 12.3 3.0 8.9 6.4 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF465) ABC_tran_CTD PF16326.5 KOO35624.1 - 0.18 12.1 4.8 5.8 7.2 0.6 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain SlyX PF04102.12 KOO35624.1 - 0.52 11.0 8.1 0.71 10.5 0.2 3.0 2 1 0 2 2 2 0 SlyX RSN1_7TM PF02714.15 KOO35626.1 - 0.0014 18.0 1.8 0.0014 18.0 1.8 2.7 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate TMEM192 PF14802.6 KOO35626.1 - 0.42 9.7 2.0 3.6 6.6 0.2 2.8 2 0 0 2 2 2 0 TMEM192 family Seryl_tRNA_N PF02403.22 KOO35626.1 - 3.8 7.8 5.2 2 8.7 1.0 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TMEM52 PF14979.6 KOO35626.1 - 5.9 6.8 7.0 17 5.3 7.0 1.7 1 0 0 1 1 1 0 Transmembrane 52 PhoLip_ATPase_C PF16212.5 KOO35632.1 - 1.9e-46 158.9 16.1 2.5e-46 158.5 16.1 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 KOO35632.1 - 1.8e-09 38.2 2.6 2.3e-05 24.8 0.1 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOO35632.1 - 8.1e-07 29.0 0.0 1.7e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KOO35632.1 - 0.034 13.9 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase MerR-DNA-bind PF09278.11 KOO35632.1 - 0.11 13.1 2.1 0.35 11.5 1.6 2.1 2 0 0 2 2 2 0 MerR, DNA binding Peptidase_M1 PF01433.20 KOO35633.1 - 9.4e-46 156.1 0.0 1.3e-45 155.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 KOO35633.1 - 6.7e-35 119.6 0.0 1.2e-34 118.8 0.0 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 KOO35633.1 - 1.5e-19 70.9 0.0 2.2e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Mto2_bdg PF12808.7 KOO35634.1 - 8.8 6.7 16.5 0.82 10.0 1.7 3.3 2 1 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region ERG4_ERG24 PF01222.17 KOO35635.1 - 4.6e-130 434.2 4.2 5.5e-130 434.0 4.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 KOO35635.1 - 0.011 15.3 0.4 0.011 15.3 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1295) DUF2457 PF10446.9 KOO35635.1 - 9.1 5.3 10.9 12 4.9 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) HAGH_C PF16123.5 KOO35636.1 - 2e-27 95.5 0.0 3e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 KOO35636.1 - 9.6e-18 64.9 4.1 2.6e-17 63.5 4.1 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily cNMP_binding PF00027.29 KOO35637.1 - 9.6e-16 57.6 0.1 2.6e-09 37.0 0.0 2.5 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain LRR_6 PF13516.6 KOO35638.1 - 9.6e-61 196.7 20.1 2.6e-05 23.9 0.0 10.4 10 0 0 10 10 10 10 Leucine Rich repeat LRR_4 PF12799.7 KOO35638.1 - 8.2e-07 29.3 3.2 6.3 7.4 0.0 6.6 5 4 1 7 7 7 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO35638.1 - 0.0022 17.7 5.7 26 4.6 0.2 6.5 5 3 0 5 5 5 0 Leucine rich repeat EIF_2_alpha PF07541.12 KOO35638.1 - 0.019 15.0 1.8 2.9 8.0 1.6 3.6 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit TruB_C_2 PF16198.5 KOO35638.1 - 0.064 13.4 3.1 62 3.9 0.0 5.8 8 0 0 8 8 8 0 tRNA pseudouridylate synthase B C-terminal domain HOASN PF14515.6 KOO35638.1 - 0.23 11.8 18.8 34 4.9 1.3 6.9 1 1 6 7 7 7 0 Haem-oxygenase-associated N-terminal helices SpoU_sub_bind PF08032.12 KOO35638.1 - 0.73 10.2 6.2 18 5.7 0.1 4.2 3 1 2 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding Methyltransf_16 PF10294.9 KOO35639.1 - 2e-16 60.2 0.0 3.4e-10 39.9 0.1 2.3 2 0 0 2 2 2 2 Lysine methyltransferase tRNA_m1G_MT PF01746.21 KOO35639.1 - 6.8e-11 42.2 0.0 1.1e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Parecho_VpG PF06344.11 KOO35639.1 - 0.051 14.2 0.2 0.18 12.5 0.2 1.9 1 0 0 1 1 1 0 Parechovirus Genome-linked protein MTS PF05175.14 KOO35639.1 - 0.085 12.4 0.2 0.17 11.4 0.2 1.4 1 0 0 1 1 1 0 Methyltransferase small domain IQ PF00612.27 KOO35640.1 - 0.0022 17.6 11.1 0.47 10.4 2.3 3.7 3 0 0 3 3 3 2 IQ calmodulin-binding motif DUF2067 PF09840.9 KOO35640.1 - 0.0043 16.6 0.0 0.0076 15.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2067) Pkinase PF00069.25 KOO35641.1 - 2.8e-56 190.8 0.0 3.7e-56 190.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35641.1 - 1.7e-33 116.0 0.0 2.4e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 KOO35641.1 - 6.5e-14 52.3 0.2 1.7e-10 41.4 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO35641.1 - 2.2e-13 50.1 0.4 9.3e-08 32.2 0.1 3.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO35641.1 - 4.5e-12 45.8 4.1 1.4e-05 25.3 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KOO35641.1 - 3.7e-11 42.2 0.1 8.4e-05 22.7 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KOO35641.1 - 4e-10 40.0 0.0 1.2e-09 38.5 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Pkinase_fungal PF17667.1 KOO35641.1 - 0.00023 20.1 0.0 0.00096 18.0 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KOO35641.1 - 0.043 13.2 0.1 0.085 12.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO35641.1 - 0.073 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 KOO35641.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain DUF4129 PF13559.6 KOO35641.1 - 9.7 6.5 15.2 0.071 13.4 1.8 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4129) DUF938 PF06080.12 KOO35642.1 - 1.3e-46 159.0 0.0 1.5e-45 155.5 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_23 PF13489.6 KOO35642.1 - 0.0087 15.9 0.0 0.02 14.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain EF-hand_8 PF13833.6 KOO35643.1 - 0.0043 16.9 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO35643.1 - 0.0058 16.1 0.1 0.018 14.6 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO35643.1 - 0.02 14.4 0.0 0.064 12.8 0.0 1.9 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO35643.1 - 0.044 14.2 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO35643.1 - 0.091 12.7 1.6 0.45 10.6 0.1 2.9 2 0 0 2 2 2 0 EF-hand domain PQQ_3 PF13570.6 KOO35643.1 - 0.098 13.2 5.6 5.7 7.6 0.4 4.3 4 0 0 4 4 4 0 PQQ-like domain NHL PF01436.21 KOO35644.1 - 1.7e-34 116.1 19.6 2e-06 27.5 0.2 6.5 6 0 0 6 6 6 6 NHL repeat SGL PF08450.12 KOO35644.1 - 2.7e-22 79.5 16.0 0.00089 18.9 0.4 6.1 1 1 5 6 6 6 6 SMP-30/Gluconolactonase/LRE-like region BTB PF00651.31 KOO35644.1 - 4.1e-21 75.3 0.2 6.4e-21 74.7 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF839 PF05787.13 KOO35644.1 - 1.8e-07 30.7 3.5 0.63 9.1 0.0 4.4 1 1 4 5 5 5 4 Bacterial protein of unknown function (DUF839) ENT PF03735.14 KOO35644.1 - 1.8e-05 24.7 0.1 4.3 7.5 0.0 6.3 7 0 0 7 7 7 1 ENT domain P_proprotein PF01483.20 KOO35644.1 - 3.1e-05 23.9 0.0 20 5.3 0.0 4.9 4 1 1 5 5 5 1 Proprotein convertase P-domain Tcp10_C PF07202.13 KOO35644.1 - 4e-05 23.6 0.0 0.077 12.9 0.0 3.7 2 2 0 2 2 2 1 T-complex protein 10 C-terminus Phytase-like PF13449.6 KOO35644.1 - 6.4e-05 23.0 0.0 0.84 9.5 0.0 4.3 3 1 2 5 5 5 1 Esterase-like activity of phytase WG_beta_rep PF14903.6 KOO35644.1 - 0.68 10.3 9.3 44 4.5 0.0 5.2 6 0 0 6 6 6 0 WG containing repeat LTXXQ PF07813.12 KOO35645.1 - 0.31 11.8 6.6 0.31 11.8 0.0 3.3 3 1 0 3 3 3 0 LTXXQ motif family protein Acyltransferase PF01553.21 KOO35646.1 - 4.2e-20 71.8 0.0 5.4e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase DUF809 PF05663.11 KOO35646.1 - 0.2 11.8 0.1 0.28 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF809) ECH_2 PF16113.5 KOO35647.1 - 1.3e-104 350.3 0.0 1.9e-104 349.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KOO35647.1 - 2.3e-29 102.5 0.0 2.1e-27 96.1 0.0 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase NPV_P10 PF05531.12 KOO35648.1 - 0.015 15.8 10.3 0.034 14.6 0.1 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 KOO35648.1 - 0.047 13.7 2.5 0.59 10.2 0.0 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus BRCT PF00533.26 KOO35648.1 - 0.058 13.8 3.1 15 6.0 2.0 3.6 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain IFT57 PF10498.9 KOO35648.1 - 0.12 11.3 22.1 0.27 10.2 22.1 1.5 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 HSBP1 PF06825.12 KOO35648.1 - 0.17 11.7 1.1 1.2 9.1 0.8 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 APG6_N PF17675.1 KOO35648.1 - 0.79 10.3 34.0 13 6.3 15.1 2.7 1 1 1 2 2 2 0 Apg6 coiled-coil region PAP_central PF04928.17 KOO35648.1 - 0.93 8.4 6.9 0.29 10.1 3.2 1.9 2 1 0 2 2 2 0 Poly(A) polymerase central domain FapA PF03961.13 KOO35648.1 - 1.8 7.0 24.7 0.95 8.0 9.7 2.2 1 1 1 2 2 2 0 Flagellar Assembly Protein A Snapin_Pallidin PF14712.6 KOO35648.1 - 2.6 8.5 26.3 1.1 9.7 2.1 3.9 1 1 3 4 4 4 0 Snapin/Pallidin PspA_IM30 PF04012.12 KOO35648.1 - 3 7.4 36.7 3.5 7.2 1.1 3.2 1 1 1 2 2 2 0 PspA/IM30 family DUF4407 PF14362.6 KOO35648.1 - 5.2 6.3 28.5 2.3 7.5 11.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 KOO35648.1 - 5.6 7.4 28.6 2.1 8.8 4.4 2.3 1 1 1 2 2 2 0 Fez1 Sec34 PF04136.15 KOO35648.1 - 6 6.7 14.6 0.7 9.8 5.5 2.9 1 1 1 3 3 3 0 Sec34-like family DUF1192 PF06698.11 KOO35648.1 - 7.3 6.7 15.7 2.3 8.3 0.1 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) R3H PF01424.22 KOO35649.1 - 5.2e-15 55.2 0.0 7.3e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 KOO35649.1 - 9.4e-09 35.0 3.3 1.9e-08 34.1 3.3 1.6 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KOO35649.1 - 0.0013 18.8 1.2 0.0024 17.9 1.2 1.4 1 0 0 1 1 1 1 G-patch domain DUF1694 PF07997.11 KOO35649.1 - 0.032 14.3 0.0 0.043 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) EF-hand_1 PF00036.32 KOO35650.1 - 6.5e-21 72.3 0.2 5.6e-06 25.5 0.0 4.4 4 1 1 5 5 5 3 EF hand EF-hand_6 PF13405.6 KOO35650.1 - 2.5e-18 64.4 0.8 3.7e-05 23.3 0.0 4.7 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KOO35650.1 - 1.5e-15 55.9 0.2 3.8e-06 26.2 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO35650.1 - 1.7e-14 54.0 0.4 2.2e-06 28.0 0.3 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO35650.1 - 2.5e-12 46.5 0.4 4.5e-06 26.4 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain pair Caleosin PF05042.13 KOO35650.1 - 0.078 12.9 0.1 13 5.7 0.0 2.8 2 1 1 3 3 3 0 Caleosin related protein DUF4099 PF13351.6 KOO35650.1 - 0.1 12.9 0.0 0.39 11.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4099) SET PF00856.28 KOO35653.1 - 2.1e-20 73.8 2.0 1.1e-09 39.0 0.2 3.6 3 1 0 3 3 3 2 SET domain SAF PF08666.12 KOO35653.1 - 0.057 14.0 0.0 7.1 7.3 0.0 3.0 2 0 0 2 2 2 0 SAF domain DUF3228 PF11539.8 KOO35654.1 - 2.1e-85 285.2 0.0 2.3e-85 285.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) Torus PF16131.5 KOO35656.1 - 3.6e-07 30.9 1.1 9e-07 29.6 1.1 1.7 1 1 0 1 1 1 1 Torus domain zf-CCCH_4 PF18044.1 KOO35656.1 - 4.4e-06 26.3 2.4 8.5e-06 25.4 2.4 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 KOO35656.1 - 9.9e-06 25.3 3.6 2e-05 24.4 3.6 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOO35656.1 - 1.4e-05 25.0 6.9 2.6e-05 24.1 6.9 1.5 1 0 0 1 1 1 1 Zinc finger domain F-box PF00646.33 KOO35656.1 - 0.0052 16.6 0.0 0.0093 15.8 0.0 1.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOO35656.1 - 0.0054 16.6 0.5 0.011 15.7 0.5 1.5 1 0 0 1 1 1 1 F-box-like zf-CCCH_3 PF15663.5 KOO35656.1 - 0.015 15.5 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 KOO35656.1 - 0.036 14.6 2.7 0.062 13.8 2.7 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Ank_2 PF12796.7 KOO35658.1 - 1.3e-18 67.3 0.8 3.9e-10 40.2 0.0 3.5 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) ADPrib_exo_Tox PF03496.14 KOO35658.1 - 9.4e-17 61.0 0.0 4.6e-09 35.9 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO35658.1 - 8.1e-14 51.4 0.0 4.4e-06 26.1 0.0 2.5 3 0 0 3 3 3 2 NAD:arginine ADP-ribosyltransferase Ank_5 PF13857.6 KOO35658.1 - 2.1e-13 50.2 2.3 5.1e-05 23.5 0.4 4.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO35658.1 - 2.9e-13 49.6 5.3 0.00066 20.0 0.1 6.0 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 KOO35658.1 - 8.1e-11 42.2 0.7 0.00019 21.9 0.1 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35658.1 - 2.5e-10 39.7 2.3 0.015 15.8 0.0 5.9 6 0 0 6 6 6 2 Ankyrin repeat Dus PF01207.17 KOO35659.1 - 3.3e-12 46.1 0.0 3.8e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) CLP1_P PF16575.5 KOO35660.1 - 1.5e-51 174.9 0.0 2.2e-51 174.3 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 KOO35660.1 - 3.3e-29 100.9 0.0 8.5e-29 99.6 0.0 1.7 2 0 0 2 2 2 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 KOO35660.1 - 2.2e-23 82.9 0.0 3.3e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 AAA_16 PF13191.6 KOO35660.1 - 0.0019 18.6 0.1 0.0032 17.9 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 KOO35660.1 - 0.01 15.9 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 KOO35660.1 - 0.028 14.1 1.1 0.15 11.7 1.0 2.0 1 1 0 1 1 1 0 AAA domain ANTAR PF03861.14 KOO35660.1 - 0.036 13.9 0.0 0.082 12.8 0.0 1.7 1 0 0 1 1 1 0 ANTAR domain Cytidylate_kin PF02224.18 KOO35660.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase DUF2475 PF10629.9 KOO35661.1 - 1.5e-26 92.4 14.4 1.6e-06 28.2 0.1 5.5 5 0 0 5 5 5 5 Protein of unknown function (DUF2475) LD_cluster2 PF18163.1 KOO35661.1 - 0.24 10.9 0.7 20 4.6 0.0 3.4 4 0 0 4 4 4 0 SLOG cluster2 Glyco_trans_1_4 PF13692.6 KOO35662.1 - 5.3e-06 26.9 0.3 1.1e-05 25.9 0.3 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 KOO35662.1 - 0.00069 19.2 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Sec63 PF02889.16 KOO35663.1 - 8.5e-05 21.8 0.0 0.00012 21.3 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain PCI PF01399.27 KOO35664.1 - 2.8e-12 47.0 0.0 8.3e-12 45.5 0.0 1.9 1 0 0 1 1 1 1 PCI domain FliP PF00813.20 KOO35664.1 - 0.13 12.1 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 FliP family ABC2_membrane PF01061.24 KOO35665.1 - 7.2e-35 120.3 9.3 7.2e-35 120.3 9.3 2.1 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KOO35665.1 - 6.4e-23 81.8 0.0 9.6e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 KOO35665.1 - 1.8e-07 30.6 5.8 3.5e-07 29.7 5.8 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 KOO35665.1 - 0.00028 20.8 0.3 0.00053 19.9 0.3 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 KOO35665.1 - 0.00039 20.8 0.2 0.00091 19.6 0.2 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 KOO35665.1 - 0.00044 20.2 0.2 0.28 10.9 0.0 2.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 KOO35665.1 - 0.011 15.5 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO35665.1 - 0.029 14.3 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 KOO35665.1 - 0.036 14.0 0.0 0.059 13.3 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea SMC_N PF02463.19 KOO35665.1 - 0.061 12.8 0.1 2 7.8 0.1 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOO35665.1 - 0.073 12.8 0.4 0.17 11.7 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 KOO35665.1 - 0.084 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOO35665.1 - 0.084 13.1 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 KOO35665.1 - 0.089 13.2 0.0 0.22 12.0 0.0 1.6 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 KOO35665.1 - 0.14 12.2 0.2 0.26 11.4 0.2 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF87 PF01935.17 KOO35665.1 - 0.14 12.2 0.1 0.23 11.6 0.1 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_25 PF13481.6 KOO35665.1 - 0.19 11.3 0.1 0.34 10.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 KOO35665.1 - 0.2 11.9 0.0 0.48 10.6 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC2_membrane_2 PF12679.7 KOO35665.1 - 3.4 6.9 6.1 15 4.8 4.5 2.1 1 1 0 1 1 1 0 ABC-2 family transporter protein WBS_methylT PF12589.8 KOO35666.1 - 1.1e-15 58.1 2.4 1.9e-15 57.3 2.4 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 KOO35666.1 - 2.3e-14 53.8 0.0 4.1e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO35666.1 - 4.5e-12 46.5 0.0 9.9e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO35666.1 - 4e-06 27.5 0.0 9.3e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO35666.1 - 1.8e-05 24.6 0.0 2.5e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO35666.1 - 0.00037 20.4 0.0 0.00055 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO35666.1 - 0.0038 16.6 0.0 0.0077 15.6 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family AdoMet_MTase PF07757.13 KOO35666.1 - 0.0054 17.1 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase MetW PF07021.12 KOO35666.1 - 0.058 13.0 0.0 0.083 12.5 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CMAS PF02353.20 KOO35666.1 - 0.066 12.5 0.0 0.095 12.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase N6_N4_Mtase PF01555.18 KOO35666.1 - 0.085 12.6 0.0 1.2 8.8 0.0 2.1 2 0 0 2 2 2 0 DNA methylase UQ_con PF00179.26 KOO35667.1 - 1.7e-43 147.6 0.0 2e-43 147.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOO35667.1 - 0.00046 20.5 0.0 0.00049 20.4 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KOO35667.1 - 0.017 15.0 0.0 0.028 14.3 0.0 1.4 1 1 0 1 1 1 0 UEV domain DUF1779 PF08680.10 KOO35668.1 - 0.3 11.3 2.8 0.56 10.4 2.8 1.4 1 0 0 1 1 1 0 TATA-box binding EF-hand_14 PF17959.1 KOO35668.1 - 0.97 9.8 0.0 0.97 9.8 0.0 2.5 3 0 0 3 3 3 0 EF-hand domain Bap31_Bap29_C PF18035.1 KOO35668.1 - 8.5 6.5 8.2 10 6.2 0.1 3.8 3 0 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Kinesin PF00225.23 KOO35669.1 - 1.3e-80 270.9 0.0 4.9e-50 170.3 0.2 2.1 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KOO35669.1 - 1.5e-21 76.9 0.0 3.8e-20 72.4 0.0 2.4 1 1 0 1 1 1 1 Microtubule binding DcrB PF08786.11 KOO35669.1 - 0.13 12.4 0.1 0.28 11.3 0.1 1.5 1 0 0 1 1 1 0 DcrB PIF1 PF05970.14 KOO35669.1 - 0.21 10.7 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase Heme_oxygenase PF01126.20 KOO35671.1 - 6.9e-15 55.4 0.0 1.1e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 Heme oxygenase LRR_5 PF13306.6 KOO35672.1 - 1.6e-65 218.8 0.1 2.2e-36 124.7 0.0 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO35672.1 - 3.1e-11 42.9 0.0 0.024 14.4 0.0 6.2 2 1 6 8 8 8 7 Leucine rich repeat Forkhead_N PF08430.12 KOO35672.1 - 1 10.0 10.2 8.2 7.0 4.6 2.6 1 1 1 2 2 2 0 Forkhead N-terminal region DnaJ PF00226.31 KOO35674.1 - 4.1e-26 90.9 1.4 6.3e-26 90.3 1.4 1.3 1 0 0 1 1 1 1 DnaJ domain EF-hand_6 PF13405.6 KOO35674.1 - 2e-07 30.4 0.0 0.038 13.9 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO35674.1 - 2.3e-07 31.2 0.0 0.0027 18.1 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO35674.1 - 1.5e-05 24.2 0.0 0.088 12.4 0.0 2.9 2 0 0 2 2 2 2 EF hand EFhand_Ca_insen PF08726.10 KOO35674.1 - 0.0022 18.1 0.2 2.7 8.1 0.0 2.8 4 0 0 4 4 4 2 Ca2+ insensitive EF hand EF-hand_8 PF13833.6 KOO35674.1 - 0.0093 15.8 0.0 5.5 6.9 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO35674.1 - 0.051 13.1 0.0 1.9 8.2 0.0 2.8 2 1 0 2 2 2 0 EF hand DUF4769 PF15992.5 KOO35675.1 - 0.12 12.2 0.0 0.15 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) Glyco_transf_25 PF01755.17 KOO35675.1 - 0.2 11.5 0.0 0.69 9.7 0.0 1.7 1 1 1 2 2 2 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Rubis-subs-bind PF09273.11 KOO35676.1 - 3.8e-12 47.0 0.2 1.2e-11 45.5 0.0 1.8 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding SET PF00856.28 KOO35676.1 - 2.9e-08 34.3 0.0 5.1e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 SET domain Herpes_capsid PF06112.11 KOO35676.1 - 1.8 8.6 5.2 4.1 7.4 5.2 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein LRR_6 PF13516.6 KOO35677.1 - 9.3e-30 100.1 4.7 4.2e-06 26.4 0.0 6.3 6 0 0 6 6 6 5 Leucine Rich repeat SpoU_sub_bind PF08032.12 KOO35677.1 - 3.5e-07 30.4 1.1 0.36 11.1 0.0 4.3 2 2 2 4 4 4 2 RNA 2'-O ribose methyltransferase substrate binding LRR_4 PF12799.7 KOO35677.1 - 8.3e-07 29.2 0.1 0.39 11.2 0.2 5.1 3 1 2 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO35677.1 - 0.00049 19.8 0.6 12 5.8 0.1 5.0 2 1 1 3 3 3 1 Leucine rich repeat LRR_1 PF00560.33 KOO35677.1 - 0.0012 19.1 0.0 80 4.4 0.0 5.3 6 0 0 6 6 6 0 Leucine Rich Repeat EIF_2_alpha PF07541.12 KOO35677.1 - 0.0038 17.3 1.5 3.9 7.6 0.4 3.7 2 1 1 3 3 3 1 Eukaryotic translation initiation factor 2 alpha subunit CbiG_N PF11760.8 KOO35677.1 - 0.072 13.1 13.6 0.93 9.5 0.7 4.4 5 1 1 6 6 6 0 Cobalamin synthesis G N-terminal SepF PF04472.12 KOO35677.1 - 0.094 13.0 0.3 5.1 7.5 0.0 3.1 3 1 2 5 5 5 0 Cell division protein SepF PARP PF00644.20 KOO35677.1 - 0.1 12.2 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain HTH_3 PF01381.22 KOO35677.1 - 0.13 12.4 0.9 1.7 8.8 0.1 2.9 3 0 0 3 3 3 0 Helix-turn-helix FAM25 PF15825.5 KOO35677.1 - 0.78 10.1 21.4 23 5.4 0.5 6.0 5 1 1 6 6 6 0 FAM25 family Pkinase PF00069.25 KOO35680.1 - 2.8e-66 223.6 0.0 3.5e-66 223.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35680.1 - 3.6e-31 108.4 0.0 5.3e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO35680.1 - 0.00015 21.2 0.3 0.00026 20.4 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOO35680.1 - 0.00031 19.8 0.3 0.00048 19.2 0.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KOO35680.1 - 0.006 16.2 0.5 0.011 15.3 0.5 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KOO35680.1 - 0.05 13.5 0.4 0.12 12.3 0.2 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family cNMP_binding PF00027.29 KOO35681.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain TraH PF06122.11 KOO35682.1 - 0.0049 16.2 0.2 0.009 15.3 0.2 1.3 1 0 0 1 1 1 1 Conjugative relaxosome accessory transposon protein ANTAR PF03861.14 KOO35682.1 - 0.028 14.3 2.8 0.032 14.1 0.6 2.4 2 1 0 2 2 2 0 ANTAR domain DUF1192 PF06698.11 KOO35682.1 - 0.053 13.6 0.5 1.5 8.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Gram_pos_anchor PF00746.21 KOO35682.1 - 3.4 7.7 8.4 1 9.4 2.2 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif ThylakoidFormat PF11264.8 KOO35683.1 - 1.3e-26 93.6 0.0 9.4e-26 90.8 0.0 2.2 1 1 1 2 2 2 1 Thylakoid formation protein RPA43_OB PF17875.1 KOO35683.1 - 0.29 11.7 1.2 0.45 11.1 1.2 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I ABC_export PF16962.5 KOO35683.1 - 2.8 6.3 3.2 4.6 5.6 3.2 1.3 1 0 0 1 1 1 0 Putative ABC exporter NAD_binding_8 PF13450.6 KOO35684.1 - 1.7e-06 28.2 0.0 3.2e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KOO35684.1 - 0.0083 15.5 0.0 0.026 13.8 0.0 1.7 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 KOO35684.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding Fer2 PF00111.27 KOO35685.1 - 2.9e-12 46.4 0.5 3.7e-12 46.0 0.5 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain MCR PF18509.1 KOO35685.1 - 0.11 12.0 0.1 0.24 11.0 0.1 1.5 1 0 0 1 1 1 0 Magnetochrome domain SH3BP5 PF05276.14 KOO35686.1 - 2.4e-06 27.6 20.8 3.1e-05 23.9 19.4 2.1 1 1 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DUF1192 PF06698.11 KOO35686.1 - 0.11 12.6 0.6 0.11 12.6 0.6 4.0 3 2 2 5 5 5 0 Protein of unknown function (DUF1192) zf-C4H2 PF10146.9 KOO35686.1 - 0.16 12.3 7.4 1.8 8.8 3.6 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein Fez1 PF06818.15 KOO35686.1 - 1.1 9.6 18.5 0.13 12.7 2.8 2.2 2 0 0 2 2 2 0 Fez1 RHD3 PF05879.12 KOO35686.1 - 3.3 5.7 8.6 0.65 8.1 2.6 1.8 1 1 0 2 2 2 0 Root hair defective 3 GTP-binding protein (RHD3) BAR_3 PF16746.5 KOO35686.1 - 4 7.1 11.3 0.43 10.2 4.2 2.1 1 1 1 2 2 2 0 BAR domain of APPL family Spc7 PF08317.11 KOO35686.1 - 4.5 6.1 20.0 0.41 9.5 3.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein KIP1 PF07765.12 KOO35686.1 - 5.5 7.2 6.5 2.2 8.5 0.6 2.8 3 1 0 3 3 3 0 KIP1-like protein APG6_N PF17675.1 KOO35686.1 - 5.5 7.5 24.3 3 8.4 11.0 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region Alpha_kinase PF02816.18 KOO35687.1 - 1.9e-30 106.4 0.0 3.8e-30 105.4 0.0 1.6 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.6 KOO35687.1 - 9.5e-08 32.7 0.0 4.5e-07 30.5 0.0 2.3 1 0 0 1 1 1 1 von Willebrand factor type A domain YbgS PF13985.6 KOO35688.1 - 2 8.7 5.6 1.1 9.5 0.4 2.1 2 0 0 2 2 2 0 YbgS-like protein Stm1_N PF09598.10 KOO35688.1 - 8.5 7.3 12.8 4.5 8.2 1.7 2.3 2 0 0 2 2 2 0 Stm1 CoA_trans PF01144.23 KOO35690.1 - 4.1e-105 350.0 1.6 6.6e-68 228.3 0.4 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 KOO35690.1 - 0.0027 17.6 0.0 0.0049 16.8 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Peptidase_S77 PF03420.13 KOO35691.1 - 0.039 13.6 0.0 0.071 12.8 0.0 1.4 1 0 0 1 1 1 0 Prohead core protein serine protease PABP PF00658.18 KOO35692.1 - 3.9e-08 33.4 0.0 7.6e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain OTU PF02338.19 KOO35692.1 - 5.2e-06 27.0 0.0 9.2e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease zinc_ribbon_2 PF13240.6 KOO35696.1 - 0.14 11.9 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Peptidase_S8 PF00082.22 KOO35697.1 - 1e-21 77.5 12.5 1e-18 67.6 12.5 3.6 1 1 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KOO35697.1 - 8.5e-08 32.1 0.0 1e-06 28.7 0.0 2.4 2 0 0 2 2 2 1 Proprotein convertase P-domain Arm PF00514.23 KOO35698.1 - 2.3e-106 345.0 57.1 2.2e-09 37.0 0.4 13.0 13 0 0 13 13 13 13 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 KOO35698.1 - 1.8e-14 53.8 8.2 0.00015 21.3 0.1 5.3 1 1 4 5 5 5 4 Armadillo-like HEAT_EZ PF13513.6 KOO35698.1 - 7.9e-12 45.4 44.0 0.003 18.0 0.8 8.9 3 2 7 10 10 10 10 HEAT-like repeat RPAP1_C PF08620.10 KOO35698.1 - 1e-08 35.1 9.6 57 3.9 0.0 11.7 13 0 0 13 13 13 0 RPAP1-like, C-terminal SNAD2 PF18745.1 KOO35698.1 - 5.7e-07 29.4 0.4 9.4 5.9 0.0 7.6 2 2 8 10 10 10 1 Secreted Novel AID/APOBEC-like Deaminase 2 Prok-E2_C PF14459.6 KOO35698.1 - 1.1e-06 28.8 30.7 1 9.5 0.3 8.0 1 1 5 8 8 8 5 Prokaryotic E2 family C CRS1_YhbY PF01985.21 KOO35698.1 - 1.6e-06 28.2 4.7 8 6.7 0.0 8.3 12 0 0 12 12 11 2 CRS1 / YhbY (CRM) domain KAP PF05804.12 KOO35698.1 - 4.5e-06 25.1 0.0 0.21 9.7 0.0 3.5 1 1 2 4 4 4 2 Kinesin-associated protein (KAP) Atx10homo_assoc PF09759.9 KOO35698.1 - 0.00041 20.3 15.8 0.12 12.5 0.1 6.7 3 2 3 8 8 8 2 Spinocerebellar ataxia type 10 protein domain LSDAT_euk PF18139.1 KOO35698.1 - 0.009 15.4 5.1 1.5 8.1 0.2 3.8 1 1 0 4 4 4 1 SLOG in TRPM Ig_mannosidase PF17753.1 KOO35698.1 - 0.42 10.4 15.1 1.2e+02 2.6 0.0 8.8 10 2 1 12 12 12 0 Ig-fold domain Stimulus_sens_1 PF13756.6 KOO35698.1 - 1.2 9.8 3.3 1.1e+02 3.4 0.1 4.2 4 0 0 4 4 4 0 Stimulus-sensing domain DUF2046 PF09755.9 KOO35699.1 - 5.3e-22 78.4 41.0 1.2e-21 77.3 27.1 2.5 2 1 0 2 2 2 2 Uncharacterized conserved protein H4 (DUF2046) Rootletin PF15035.6 KOO35699.1 - 0.00018 21.6 3.0 0.00018 21.6 3.0 2.7 1 1 1 2 2 2 1 Ciliary rootlet component, centrosome cohesion IPPT PF01715.17 KOO35699.1 - 0.034 14.0 0.5 0.034 14.0 0.5 2.4 2 0 0 2 2 2 0 IPP transferase MetW PF07021.12 KOO35699.1 - 0.48 10.0 2.6 0.78 9.3 2.6 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DUF4686 PF15742.5 KOO35699.1 - 0.64 9.1 40.2 0.27 10.3 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4686) Phage_Mu_Gam PF07352.12 KOO35699.1 - 2 8.3 23.1 1.6 8.6 5.0 3.3 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein PRKG1_interact PF15898.5 KOO35699.1 - 6.2 7.8 35.4 0.1 13.5 2.7 3.5 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain UPRTase PF14681.6 KOO35700.1 - 2.2e-67 226.5 0.0 3.1e-67 226.0 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 KOO35700.1 - 0.00013 21.5 0.1 0.0002 20.9 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PTR2 PF00854.21 KOO35702.1 - 4.8e-58 196.9 2.6 1e-36 126.7 1.6 3.1 2 1 1 3 3 3 3 POT family MFS_1 PF07690.16 KOO35702.1 - 5.4e-09 35.4 17.8 7e-09 35.1 17.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Adaptin_N PF01602.20 KOO35705.1 - 1.2e-81 274.8 0.9 1.8e-81 274.3 0.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AD PF09793.9 KOO35705.1 - 1.5e-12 47.5 0.0 3.1e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain Cnd1 PF12717.7 KOO35705.1 - 5.5e-10 39.5 0.1 4.3e-09 36.6 0.0 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOO35705.1 - 4.5e-06 27.0 0.2 0.045 14.1 0.1 3.9 2 1 1 3 3 3 2 HEAT repeats Cnd3 PF12719.7 KOO35705.1 - 0.00035 19.9 0.3 0.028 13.6 0.1 2.6 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 KOO35705.1 - 0.0063 16.7 1.0 2.2 8.8 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 KOO35705.1 - 0.068 13.7 5.7 11 6.6 0.0 5.0 5 1 0 5 5 5 0 HEAT-like repeat ParcG PF10274.9 KOO35705.1 - 0.17 12.0 2.9 0.76 9.9 0.0 3.1 3 1 0 4 4 4 0 Parkin co-regulated protein SAP PF02037.27 KOO35707.1 - 7.2e-11 41.6 0.1 8.4e-11 41.4 0.1 1.1 1 0 0 1 1 1 1 SAP domain Pkinase PF00069.25 KOO35708.1 - 1.6e-66 224.4 0.0 2e-66 224.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35708.1 - 3.6e-33 114.9 0.0 4.9e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO35708.1 - 0.0018 17.7 0.6 0.0042 16.4 0.4 1.8 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOO35708.1 - 0.0022 17.0 1.9 0.0043 16.0 1.9 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOO35708.1 - 0.026 13.9 1.5 0.048 13.0 0.9 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FeoB_N PF02421.18 KOO35708.1 - 0.028 14.0 0.4 0.16 11.5 0.5 1.9 1 1 1 2 2 2 0 Ferrous iron transport protein B APH PF01636.23 KOO35708.1 - 0.047 13.6 0.1 0.52 10.2 0.1 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family Guanylate_cyc PF00211.20 KOO35710.1 - 7.8e-09 35.4 0.0 1.4e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ion_trans PF00520.31 KOO35710.1 - 1.9e-05 24.0 1.8 1.9e-05 24.0 1.8 2.2 2 0 0 2 2 2 1 Ion transport protein Flg_bb_rod PF00460.20 KOO35710.1 - 0.2 11.7 0.4 2.7 8.0 0.1 2.5 2 0 0 2 2 2 0 Flagella basal body rod protein Pro_isomerase PF00160.21 KOO35711.1 - 9.4e-47 159.2 0.0 1e-46 159.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MatE PF01554.18 KOO35712.1 - 3.3e-26 91.8 25.6 5.6e-14 52.1 5.3 2.7 3 0 0 3 3 3 2 MatE UPF0242 PF06785.11 KOO35712.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Pkinase_Tyr PF07714.17 KOO35713.1 - 1.3e-24 86.8 0.1 1.9e-24 86.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO35713.1 - 7.4e-21 74.7 0.0 1.2e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Methyltransf_32 PF13679.6 KOO35714.1 - 5.1e-12 46.0 2.0 6.4e-11 42.5 2.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO35714.1 - 0.0043 17.7 0.0 0.0093 16.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TFCD_C PF12612.8 KOO35715.1 - 1.2e-21 77.4 0.4 2.7e-21 76.3 0.4 1.5 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal Cnd1 PF12717.7 KOO35715.1 - 0.011 15.8 0.1 0.053 13.6 0.0 2.2 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOO35715.1 - 0.036 14.4 0.2 0.036 14.4 0.2 5.7 7 1 1 8 8 8 0 HEAT repeats Vac14_Fab1_bd PF12755.7 KOO35715.1 - 0.11 13.1 0.0 3.6 8.2 0.0 3.3 4 1 1 5 5 5 0 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KOO35715.1 - 0.68 10.3 0.0 0.68 10.3 0.0 6.6 8 0 0 8 8 8 0 HEAT repeat HCV_NS5a_C PF12941.7 KOO35715.1 - 2.2 8.0 6.3 0.1 12.4 0.3 1.7 2 0 0 2 2 2 0 HCV NS5a protein C-terminal region NYN PF01936.18 KOO35716.1 - 2.5e-19 70.2 0.0 4.1e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 NYN domain PhoPQ_related PF10142.9 KOO35717.1 - 4.7e-93 311.8 0.0 5.5e-93 311.5 0.0 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein DNA_pol_A_exo1 PF01612.20 KOO35718.1 - 5.1e-05 23.0 0.1 0.09 12.5 0.0 2.1 2 0 0 2 2 2 2 3'-5' exonuclease PhoPQ_related PF10142.9 KOO35720.1 - 1.9e-68 230.8 0.0 2.2e-68 230.6 0.0 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein zf-CDGSH PF09360.10 KOO35721.1 - 1.5e-07 31.5 0.9 3.1e-07 30.5 0.9 1.6 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type tRNA_U5-meth_tr PF05958.11 KOO35722.1 - 1e-80 271.4 0.0 1e-54 185.9 0.0 2.1 2 0 0 2 2 2 2 tRNA (Uracil-5-)-methyltransferase Methyltransf_25 PF13649.6 KOO35722.1 - 0.00019 22.1 0.2 0.0013 19.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOO35722.1 - 0.00045 19.7 0.0 0.00071 19.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_15 PF09445.10 KOO35722.1 - 0.0011 18.6 0.0 0.0033 17.0 0.0 1.8 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 KOO35722.1 - 0.0049 16.5 0.0 0.052 13.2 0.1 2.1 2 0 0 2 2 2 1 Conserved hypothetical protein 95 RrnaAD PF00398.20 KOO35722.1 - 0.01 14.9 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CHAT PF12770.7 KOO35722.1 - 0.022 14.1 0.2 0.066 12.6 0.0 1.8 2 0 0 2 2 2 0 CHAT domain Methyltransf_11 PF08241.12 KOO35722.1 - 0.057 14.1 0.2 0.21 12.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain TMEM108 PF15759.5 KOO35722.1 - 0.19 10.7 4.3 0.29 10.1 4.3 1.1 1 0 0 1 1 1 0 TMEM108 family Thioredoxin PF00085.20 KOO35723.1 - 2.4e-23 82.1 0.2 4.5e-23 81.2 0.2 1.4 1 0 0 1 1 1 1 Thioredoxin PPR PF01535.20 KOO35723.1 - 1.3e-08 34.5 1.7 2.2 8.7 0.0 5.2 5 0 0 5 5 5 3 PPR repeat Thioredoxin_7 PF13899.6 KOO35723.1 - 3e-06 27.3 0.3 1.2e-05 25.3 0.1 2.2 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 KOO35723.1 - 0.00015 22.1 0.1 0.00078 19.9 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 KOO35723.1 - 0.00067 19.1 0.1 0.001 18.5 0.1 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 KOO35723.1 - 0.0041 17.4 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 KOO35723.1 - 0.0048 16.7 0.1 0.02 14.6 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin Glutaredoxin PF00462.24 KOO35723.1 - 0.0055 16.9 0.0 0.018 15.3 0.0 1.8 1 0 0 1 1 1 1 Glutaredoxin PPR_2 PF13041.6 KOO35723.1 - 0.0063 16.7 1.4 29 4.9 0.0 5.3 7 0 0 7 7 7 0 PPR repeat family Redoxin PF08534.10 KOO35723.1 - 0.02 14.6 0.1 0.06 13.1 0.0 1.8 2 0 0 2 2 2 0 Redoxin AhpC-TSA PF00578.21 KOO35723.1 - 0.069 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family PPR_1 PF12854.7 KOO35723.1 - 2.9 7.7 4.0 12 5.7 0.0 3.4 4 0 0 4 4 4 0 PPR repeat DUF3322 PF11795.8 KOO35723.1 - 5.7 6.9 11.0 5.4 7.0 0.4 4.3 3 2 1 5 5 5 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) GP67 PF17634.2 KOO35724.1 - 0.033 14.6 10.8 0.043 14.2 10.8 1.3 1 0 0 1 1 1 0 Gene product 67 CENP-B_dimeris PF09026.10 KOO35724.1 - 0.28 11.6 13.0 0.46 10.9 13.0 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 KOO35724.1 - 2 7.7 9.5 2.3 7.4 9.5 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 KOO35724.1 - 2.6 6.0 7.5 2.7 6.0 7.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi SlyX PF04102.12 KOO35725.1 - 0.25 12.0 3.6 1 10.0 0.0 2.8 2 1 0 2 2 2 0 SlyX DUF3391 PF11871.8 KOO35725.1 - 2.5 8.7 7.0 1.3 9.5 2.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Ax_dynein_light PF10211.9 KOO35729.1 - 0.0016 18.4 4.7 0.0016 18.4 4.7 2.9 2 1 1 3 3 3 1 Axonemal dynein light chain CENP-Q PF13094.6 KOO35729.1 - 0.032 14.4 5.5 1.3 9.2 0.0 3.0 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit TMPIT PF07851.13 KOO35729.1 - 0.72 9.0 4.9 0.5 9.6 0.4 2.0 2 0 0 2 2 2 0 TMPIT-like protein CENP-F_leu_zip PF10473.9 KOO35729.1 - 1.1 9.3 18.4 3 7.8 5.2 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 KOO35729.1 - 1.1 9.7 16.0 1.2 9.7 4.4 2.7 2 0 0 2 2 2 0 Apg6 coiled-coil region She9_MDM33 PF05546.11 KOO35729.1 - 1.2 9.0 5.3 0.7 9.7 0.7 2.2 2 0 0 2 2 2 0 She9 / Mdm33 family GRP PF07172.11 KOO35729.1 - 4.2 8.1 25.2 0.058 14.1 17.8 1.7 2 0 0 2 2 2 0 Glycine rich protein family Lebercilin PF15619.6 KOO35729.1 - 4.9 6.8 17.8 0.73 9.5 5.1 3.1 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Ank_2 PF12796.7 KOO35730.1 - 2.2e-79 262.1 42.8 9.8e-16 58.1 1.5 6.0 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO35730.1 - 2.6e-40 136.3 12.5 1.7e-07 31.6 0.1 7.6 5 2 2 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 KOO35730.1 - 2.1e-33 113.3 33.9 1.4e-05 25.3 0.2 10.5 10 0 0 10 10 10 9 Ankyrin repeat Ank_5 PF13857.6 KOO35730.1 - 1.8e-31 107.8 25.5 1.5e-06 28.3 0.2 10.1 1 1 9 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35730.1 - 2.1e-24 82.9 20.2 0.00037 20.7 0.0 10.3 10 0 0 10 10 10 7 Ankyrin repeat SR1P PF13790.6 KOO35730.1 - 1e-05 25.5 2.9 0.22 11.7 0.0 5.7 7 0 0 7 7 7 1 SR1 protein SpoIIIAH PF12685.7 KOO35730.1 - 1.4 8.7 8.4 2.3 8.0 8.4 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Peptidase_S49_N PF08496.10 KOO35730.1 - 2.4 8.2 6.4 3.9 7.5 1.6 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Acetyltransf_1 PF00583.25 KOO35733.1 - 4.5e-15 55.9 0.0 1.1e-14 54.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOO35733.1 - 2.4e-10 40.4 0.0 6e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOO35733.1 - 2.2e-08 34.4 0.0 5.3e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Chromo PF00385.24 KOO35733.1 - 8e-07 28.9 0.1 3.8e-06 26.7 0.1 2.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain FR47 PF08445.10 KOO35733.1 - 0.0014 18.5 0.0 0.0041 17.0 0.0 1.8 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 KOO35733.1 - 0.052 13.3 0.1 1.2 8.9 0.0 2.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_CG PF14542.6 KOO35733.1 - 0.13 12.4 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Rdx PF10262.9 KOO35734.1 - 7.2e-06 26.1 0.0 7.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Rdx family BCDHK_Adom3 PF10436.9 KOO35735.1 - 2.1e-18 66.7 0.0 3.7e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase EF-hand_1 PF00036.32 KOO35735.1 - 2.8e-11 42.1 0.1 0.00016 21.0 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO35735.1 - 5.8e-09 35.2 0.3 0.00027 20.6 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO35735.1 - 8.7e-09 35.7 0.9 2e-08 34.6 0.9 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO35735.1 - 1.2e-07 30.9 0.0 0.012 15.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO35735.1 - 3e-05 23.8 0.2 0.032 14.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair HATPase_c PF02518.26 KOO35735.1 - 0.015 15.8 0.0 0.025 15.1 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase O-FucT PF10250.9 KOO35736.1 - 0.14 11.8 0.0 0.33 10.6 0.0 1.5 1 1 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase RPGR1_C PF18111.1 KOO35739.1 - 7.1e-11 42.3 0.0 0.21 11.5 0.0 4.4 4 0 0 4 4 4 4 Retinitis pigmentosa G-protein regulator interacting C-terminal FapA PF03961.13 KOO35739.1 - 1.3 7.5 4.6 2 6.9 4.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A XRN_M PF17846.1 KOO35740.1 - 4.8e-35 121.4 0.0 8.5e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 Xrn1 helical domain TPR_12 PF13424.6 KOO35740.1 - 8.9e-31 106.0 11.1 1e-12 48.1 2.2 4.9 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 KOO35740.1 - 6.2e-25 86.3 23.9 4e-06 26.5 0.9 8.5 7 1 0 7 7 7 5 Tetratricopeptide repeat NACHT PF05729.12 KOO35740.1 - 4.6e-09 36.4 0.0 1.1e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 KOO35740.1 - 3.9e-08 33.9 0.3 3.9e-08 33.9 0.3 2.5 2 0 0 2 2 1 1 AAA ATPase domain XRN1_D1 PF18332.1 KOO35740.1 - 6e-08 32.7 0.0 1e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain NB-ARC PF00931.22 KOO35740.1 - 7.4e-07 28.6 0.0 1.4e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TPR_MalT PF17874.1 KOO35740.1 - 1.5e-05 24.5 0.7 7.3e-05 22.3 0.7 2.0 1 1 1 2 2 2 1 MalT-like TPR region TPR_7 PF13176.6 KOO35740.1 - 0.00024 20.9 12.9 0.028 14.4 0.1 4.9 6 0 0 6 6 5 2 Tetratricopeptide repeat CHAT PF12770.7 KOO35740.1 - 0.00048 19.6 0.1 0.00099 18.6 0.1 1.6 1 0 0 1 1 1 1 CHAT domain TPR_8 PF13181.6 KOO35740.1 - 0.00048 20.1 12.3 0.088 13.1 0.0 4.4 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO35740.1 - 0.0043 16.8 11.5 0.14 12.0 0.7 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO35740.1 - 0.0055 17.0 2.7 29 5.3 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA_22 PF13401.6 KOO35740.1 - 0.0073 16.6 0.1 0.034 14.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain TPR_2 PF07719.17 KOO35740.1 - 0.043 13.9 11.5 1.3 9.3 0.8 4.6 5 0 0 5 5 3 0 Tetratricopeptide repeat PPR PF01535.20 KOO35740.1 - 0.062 13.6 0.3 0.76 10.2 0.0 2.9 3 0 0 3 3 3 0 PPR repeat KOW PF00467.29 KOO35740.1 - 0.07 13.1 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 KOW motif IstB_IS21 PF01695.17 KOO35740.1 - 0.2 11.4 0.1 0.75 9.5 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein TPR_3 PF07720.12 KOO35740.1 - 0.22 11.5 0.4 2.5 8.2 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_30 PF13604.6 KOO35740.1 - 0.54 9.9 3.6 0.71 9.6 0.2 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KOO35740.1 - 0.58 9.7 3.7 0.76 9.3 0.0 3.0 4 0 0 4 4 3 0 AAA domain TPR_11 PF13414.6 KOO35740.1 - 2.8 7.7 7.9 0.44 10.3 0.9 3.4 3 1 1 4 4 4 0 TPR repeat Arm PF00514.23 KOO35741.1 - 0.13 12.4 5.0 0.16 12.0 0.3 3.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat CENP-H PF05837.12 KOO35742.1 - 2.6 8.5 9.2 3.4 8.1 8.1 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Glyco_transf_41 PF13844.6 KOO35743.1 - 7.5e-67 225.8 0.0 1.9e-34 118.9 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 41 TPR_11 PF13414.6 KOO35743.1 - 8.7e-23 79.7 9.5 6.3e-05 22.6 0.0 8.4 6 3 3 9 9 9 5 TPR repeat TPR_2 PF07719.17 KOO35743.1 - 9.3e-20 69.1 15.2 0.0098 15.9 0.1 9.6 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO35743.1 - 4.4e-17 61.1 4.6 0.007 16.2 0.0 8.6 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO35743.1 - 4.5e-09 36.8 34.1 0.0052 17.4 0.0 7.5 6 2 1 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO35743.1 - 1.9e-08 33.8 0.7 3.1 8.2 0.0 6.2 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO35743.1 - 4.7e-08 32.9 7.3 2.2 8.9 0.0 8.5 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO35743.1 - 2.1e-06 28.0 27.3 0.059 14.2 1.2 8.4 4 1 6 10 10 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO35743.1 - 2.1e-05 24.9 5.3 0.12 12.9 0.4 5.2 3 2 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO35743.1 - 4.2e-05 23.3 0.2 2.5 8.3 0.0 6.0 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO35743.1 - 6.6e-05 23.1 20.8 0.34 11.2 0.2 6.7 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO35743.1 - 0.0014 18.7 14.2 0.1 12.8 0.2 4.7 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO35743.1 - 0.0059 16.4 11.8 0.0077 16.1 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF3856 PF12968.7 KOO35743.1 - 0.014 15.4 2.1 4.8 7.2 0.0 4.6 5 1 1 6 6 6 0 Domain of Unknown Function (DUF3856) TPR_6 PF13174.6 KOO35743.1 - 2.8 8.7 11.3 3.8 8.3 0.2 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat Glyco_transf_43 PF03360.16 KOO35747.1 - 1.2e-16 61.1 0.0 1.6e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 43 Ribosomal_L22 PF00237.19 KOO35748.1 - 1.6e-40 137.5 0.3 2.3e-40 137.0 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_S6e PF01092.19 KOO35749.1 - 1.4e-43 147.8 1.3 1.4e-43 147.8 1.3 1.6 2 0 0 2 2 2 1 Ribosomal protein S6e Vma12 PF11712.8 KOO35749.1 - 1.1 9.4 4.7 1.8 8.6 4.7 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase BRAP2 PF07576.12 KOO35750.1 - 2.6e-22 78.9 0.0 4.8e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 KOO35750.1 - 3e-16 59.5 5.1 3e-16 59.5 5.1 1.9 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-CCCH PF00642.24 KOO35750.1 - 5.4e-11 42.1 11.6 3.1e-07 30.1 1.4 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_2 PF13639.6 KOO35750.1 - 3.3e-08 33.7 9.8 3.3e-08 33.7 9.8 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOO35750.1 - 5.8e-06 26.1 8.0 5.8e-06 26.1 8.0 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOO35750.1 - 9.7e-05 22.6 8.7 0.00012 22.2 5.8 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KOO35750.1 - 0.00021 21.2 2.5 0.00021 21.2 2.5 2.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOO35750.1 - 0.00028 20.7 7.3 0.00028 20.7 7.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 KOO35750.1 - 0.001 19.0 1.4 0.001 19.0 1.4 2.5 2 0 0 2 2 2 1 Zinc finger domain zf-C3HC4_3 PF13920.6 KOO35750.1 - 0.0022 17.8 18.5 0.0037 17.1 6.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOO35750.1 - 0.0041 16.8 5.4 0.0041 16.8 5.4 2.4 2 0 0 2 2 2 1 RING-like zinc finger RRM_1 PF00076.22 KOO35750.1 - 0.0079 16.0 0.0 6.2 6.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-ANAPC11 PF12861.7 KOO35750.1 - 0.03 14.4 4.4 0.09 12.8 4.4 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Torus PF16131.5 KOO35750.1 - 0.035 14.8 1.4 0.7 10.6 0.1 2.5 2 0 0 2 2 2 0 Torus domain MRP-S31 PF15433.6 KOO35750.1 - 0.16 11.6 2.7 0.27 10.8 2.7 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 zf-RING_4 PF14570.6 KOO35750.1 - 0.2 11.5 6.0 0.55 10.1 6.0 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain XhlA PF10779.9 KOO35750.1 - 4.6 7.5 4.8 1 9.6 0.8 2.0 2 0 0 2 2 2 0 Haemolysin XhlA HD_4 PF13328.6 KOO35751.1 - 3e-35 121.3 0.6 4.7e-35 120.6 0.6 1.3 1 0 0 1 1 1 1 HD domain HD PF01966.22 KOO35751.1 - 5.2e-08 33.1 0.0 1.6e-07 31.6 0.0 1.8 1 1 0 1 1 1 1 HD domain UreF PF01730.16 KOO35751.1 - 0.034 14.7 0.6 0.1 13.2 0.1 1.9 2 0 0 2 2 2 0 UreF Adipokin_hormo PF06377.11 KOO35752.1 - 0.17 12.2 2.7 0.54 10.7 0.0 2.5 2 0 0 2 2 2 0 Adipokinetic hormone VCBS PF13517.6 KOO35753.1 - 5.9e-110 359.9 123.3 5.9e-14 52.4 4.9 12.4 3 3 9 12 12 12 12 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO35753.1 - 1.7e-60 200.7 131.2 3e-05 24.0 2.2 13.6 13 0 0 13 13 13 13 FG-GAP repeat Dockerin_1 PF00404.18 KOO35753.1 - 2.3e-12 46.9 43.3 3.7 7.8 2.4 13.2 12 1 1 13 13 13 4 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO35753.1 - 2.1e-05 24.0 63.3 1.6 8.0 0.2 13.0 5 4 8 13 13 13 11 Insecticide toxin TcdB middle/N-terminal region TM_PBP2_N PF16296.5 KOO35753.1 - 3.8e-05 23.7 0.0 79 3.5 0.0 7.1 8 0 0 8 8 8 0 N-terminal of TM subunit in PBP-dependent ABC transporters 2OG-FeII_Oxy_4 PF13661.6 KOO35753.1 - 0.00046 20.8 0.0 0.00076 20.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_1 PF00036.32 KOO35753.1 - 7.9 6.3 59.0 59 3.6 0.2 13.0 13 0 0 13 13 13 0 EF hand Thioredoxin_8 PF13905.6 KOO35755.1 - 1.6e-11 44.4 0.0 4.2e-11 43.0 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Peptidase_C101 PF16218.5 KOO35755.1 - 0.16 11.2 2.9 10 5.3 0.1 3.1 2 1 1 3 3 3 0 Peptidase family C101 HpcH_HpaI PF03328.14 KOO35756.1 - 1.9e-36 125.3 2.9 3.4e-34 117.9 2.9 2.5 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family DUF1194 PF06707.11 KOO35756.1 - 0.067 12.4 0.7 0.17 11.1 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) Methyltransf_32 PF13679.6 KOO35758.1 - 4e-05 23.7 1.4 0.0004 20.4 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain TRM13 PF05206.14 KOO35758.1 - 0.054 13.0 0.0 0.14 11.7 0.0 1.7 2 1 0 2 2 2 0 Methyltransferase TRM13 MTS PF05175.14 KOO35758.1 - 0.06 12.9 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Scramblase PF03803.15 KOO35759.1 - 1.8e-09 37.2 0.0 0.00063 19.1 0.0 2.1 2 0 0 2 2 2 2 Scramblase AAA_2 PF07724.14 KOO35760.1 - 2e-55 187.5 0.0 2.9e-51 174.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 KOO35760.1 - 2.2e-32 111.1 0.6 2.2e-32 111.1 0.6 2.5 1 1 1 2 2 2 1 AAA lid domain AAA PF00004.29 KOO35760.1 - 4e-27 95.2 0.9 6.8e-13 49.2 0.0 3.2 5 0 0 5 5 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 KOO35760.1 - 3.4e-24 84.7 1.3 8.6e-24 83.4 0.1 2.5 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 KOO35760.1 - 1.1e-17 64.3 1.8 2.3e-11 43.9 0.0 4.4 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 KOO35760.1 - 3.1e-12 46.4 0.9 1.8e-08 34.4 0.1 3.1 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_22 PF13401.6 KOO35760.1 - 7.3e-10 39.2 6.9 0.0035 17.6 0.1 5.6 3 3 0 3 3 3 2 AAA domain AAA_16 PF13191.6 KOO35760.1 - 9.9e-10 39.1 5.7 9.9e-05 22.8 0.1 5.0 3 2 2 5 5 5 2 AAA ATPase domain Sigma54_activat PF00158.26 KOO35760.1 - 1.7e-09 37.6 0.0 1.9e-05 24.4 0.0 2.8 2 1 0 2 2 2 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 KOO35760.1 - 3.8e-08 33.3 0.0 0.0052 16.5 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 KOO35760.1 - 1e-06 29.3 0.6 0.029 14.9 0.0 3.2 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 KOO35760.1 - 4.6e-06 26.7 0.0 0.016 15.2 0.0 2.9 3 0 0 3 3 2 2 NACHT domain Mg_chelatase PF01078.21 KOO35760.1 - 6e-06 25.8 0.1 0.39 10.1 0.0 3.9 2 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 KOO35760.1 - 1.3e-05 25.0 2.2 0.69 9.6 0.0 4.4 4 1 0 4 4 4 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 KOO35760.1 - 1.6e-05 25.0 0.0 0.26 11.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 KOO35760.1 - 2.7e-05 23.8 0.0 0.032 13.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_23 PF13476.6 KOO35760.1 - 3.8e-05 24.3 4.6 0.62 10.5 6.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO35760.1 - 4e-05 23.8 0.8 0.19 11.9 0.0 3.8 4 1 0 4 4 3 2 AAA domain TniB PF05621.11 KOO35760.1 - 4.5e-05 22.9 0.0 0.12 11.8 0.0 3.6 2 1 0 2 2 2 1 Bacterial TniB protein RNA_helicase PF00910.22 KOO35760.1 - 4.5e-05 23.8 0.0 0.29 11.5 0.0 2.9 3 0 0 3 3 2 2 RNA helicase Zeta_toxin PF06414.12 KOO35760.1 - 0.00011 21.5 0.5 0.23 10.7 0.0 3.5 4 0 0 4 4 4 1 Zeta toxin AAA_3 PF07726.11 KOO35760.1 - 0.00019 21.3 0.1 0.23 11.3 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 KOO35760.1 - 0.00019 21.6 0.0 0.28 11.4 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 KOO35760.1 - 0.00021 21.6 0.9 1.8 8.8 0.0 3.8 3 1 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 KOO35760.1 - 0.00033 20.6 0.0 0.11 12.3 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase TsaE PF02367.17 KOO35760.1 - 0.0025 17.8 0.0 2.2 8.3 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 KOO35760.1 - 0.0034 17.3 0.0 1.6 8.6 0.0 3.5 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 KOO35760.1 - 0.0035 17.1 0.0 1.2 8.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain RapA_C PF12137.8 KOO35760.1 - 0.0043 16.1 5.4 0.009 15.1 5.3 1.5 2 0 0 2 2 1 1 RNA polymerase recycling family C-terminal TIP49 PF06068.13 KOO35760.1 - 0.0052 16.0 0.4 0.68 9.1 0.0 3.0 3 0 0 3 3 3 1 TIP49 P-loop domain DNA_pol3_delta2 PF13177.6 KOO35760.1 - 0.0057 16.5 0.0 0.34 10.7 0.0 3.1 3 0 0 3 3 3 1 DNA polymerase III, delta subunit Bac_DnaA PF00308.18 KOO35760.1 - 0.009 15.9 0.0 0.54 10.1 0.0 2.9 3 0 0 3 3 3 1 Bacterial dnaA protein ABC_tran PF00005.27 KOO35760.1 - 0.013 16.0 0.5 1.6 9.3 0.0 3.0 3 0 0 3 3 2 0 ABC transporter ResIII PF04851.15 KOO35760.1 - 0.013 15.5 0.0 1.8 8.5 0.0 3.2 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 KOO35760.1 - 0.039 13.9 0.2 12 5.8 0.0 2.8 3 0 0 3 3 2 0 NTPase T2SSE PF00437.20 KOO35760.1 - 0.041 13.0 0.0 0.11 11.6 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_17 PF13207.6 KOO35760.1 - 0.067 13.6 0.0 15 6.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KOO35760.1 - 0.08 13.0 0.0 17 5.5 0.0 3.0 3 0 0 3 3 2 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 KOO35760.1 - 0.1 12.3 0.0 2.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 KOO35760.1 - 0.13 11.8 7.2 0.16 11.5 0.1 3.6 3 1 0 3 3 3 0 AAA domain Spc7 PF08317.11 KOO35760.1 - 0.15 10.9 11.6 0.26 10.1 11.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Parvo_NS1 PF01057.17 KOO35760.1 - 0.19 10.8 0.1 36 3.3 0.0 2.9 2 1 1 3 3 3 0 Parvovirus non-structural protein NS1 EcoEI_R_C PF08463.10 KOO35760.1 - 3 7.9 7.9 16 5.6 3.9 2.6 1 1 1 2 2 2 0 EcoEI R protein C-terminal AAA_19 PF13245.6 KOO35760.1 - 3.5 8.0 6.4 12 6.2 0.1 4.1 3 2 1 4 4 4 0 AAA domain Snapin_Pallidin PF14712.6 KOO35760.1 - 4.7 7.7 9.0 7.1 7.1 2.1 3.2 2 1 1 3 3 2 0 Snapin/Pallidin RINGv PF12906.7 KOO35763.1 - 3.1e-12 46.4 2.7 6.3e-12 45.4 2.7 1.6 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 KOO35763.1 - 0.034 14.3 2.3 0.07 13.3 2.3 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 KOO35763.1 - 0.036 14.0 3.4 0.065 13.1 3.4 1.5 1 0 0 1 1 1 0 PHD-finger Aminotran_1_2 PF00155.21 KOO35765.1 - 0.0036 16.5 0.2 0.0042 16.3 0.2 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alk_phosphatase PF00245.20 KOO35765.1 - 0.052 12.5 0.1 0.058 12.3 0.1 1.0 1 0 0 1 1 1 0 Alkaline phosphatase Mito_carr PF00153.27 KOO35766.1 - 2.5e-18 65.8 11.2 1.3e-05 25.0 1.1 5.1 3 2 1 4 4 4 4 Mitochondrial carrier protein VWA PF00092.28 KOO35767.1 - 2.4e-19 70.2 0.0 2.8e-19 70.1 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KOO35767.1 - 1.1e-11 45.3 0.1 3.3e-11 43.8 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 KOO35767.1 - 7.8e-06 25.4 0.1 9.7e-06 25.1 0.1 1.1 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF1194 PF06707.11 KOO35767.1 - 0.0013 18.0 0.4 0.0017 17.6 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1194) CS PF04969.16 KOO35771.1 - 4.6e-10 40.4 0.0 7e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 CS domain Aldose_epim PF01263.20 KOO35772.1 - 1.2e-32 113.4 0.0 1.8e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase DUF3729 PF12526.8 KOO35772.1 - 4.3 8.9 8.2 11 7.6 8.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3729) DUF1729 PF08354.10 KOO35773.1 - 0.0051 15.7 0.0 0.0064 15.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) EF-hand_7 PF13499.6 KOO35776.1 - 2.9e-19 69.3 1.8 2e-08 34.6 0.4 5.5 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO35776.1 - 7.9e-17 59.7 0.1 0.0012 18.6 0.0 6.2 5 0 0 5 5 5 3 EF-hand domain EF-hand_1 PF00036.32 KOO35776.1 - 1.3e-16 58.8 0.2 9e-05 21.8 0.1 5.1 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO35776.1 - 1.2e-09 37.9 2.6 5.3e-05 23.0 0.1 5.0 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO35776.1 - 2.1e-08 33.3 7.7 0.0027 17.1 0.1 4.4 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.9 KOO35776.1 - 0.035 14.4 0.0 11 6.4 0.0 2.8 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region BACK PF07707.15 KOO35777.1 - 3.7e-23 81.6 0.0 7.2e-23 80.6 0.0 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 KOO35777.1 - 3e-22 78.9 0.1 1.6e-21 76.6 0.1 2.0 1 1 1 2 2 2 1 BTB/POZ domain SbmA_BacA PF05992.12 KOO35778.1 - 5.2e-37 128.0 0.2 2.9e-36 125.5 0.2 1.8 1 1 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.15 KOO35778.1 - 6.4e-08 32.3 0.1 1.5e-07 31.2 0.1 1.6 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 DnaJ PF00226.31 KOO35779.1 - 1.8e-05 24.7 0.2 4.9e-05 23.4 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain Activator-TraM PF11657.8 KOO35779.1 - 0.12 12.2 5.1 1.9 8.3 1.9 2.6 2 1 0 2 2 2 0 Transcriptional activator TraM ATP-synt_DE PF00401.20 KOO35779.1 - 0.36 11.1 13.7 0.15 12.3 6.5 3.0 1 1 1 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Fer4_24 PF18109.1 KOO35779.1 - 0.81 10.0 3.1 15 6.0 0.3 2.4 2 0 0 2 2 2 0 Ferredoxin I 4Fe-4S cluster domain Ion_trans PF00520.31 KOO35782.1 - 3.7e-14 52.6 1.0 5.4e-14 52.0 1.0 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO35782.1 - 0.00079 18.2 8.5 0.00079 18.2 8.5 1.8 2 1 0 2 2 2 1 Polycystin cation channel Ank_2 PF12796.7 KOO35782.1 - 0.0012 19.4 0.1 0.0034 17.9 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO35782.1 - 0.0014 19.2 0.2 1.1 10.0 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) WD40_like PF17005.5 KOO35782.1 - 0.11 11.8 0.0 8.7 5.6 0.0 2.5 3 0 0 3 3 3 0 WD40-like domain PseudoU_synth_2 PF00849.22 KOO35783.1 - 2.8e-26 92.5 0.0 5.3e-26 91.6 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase MOSC_N PF03476.16 KOO35784.1 - 2.5e-31 108.0 0.0 5e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 KOO35784.1 - 5.1e-26 91.2 0.0 8.5e-26 90.5 0.0 1.4 1 0 0 1 1 1 1 MOSC domain DUF3072 PF11272.8 KOO35785.1 - 5.5 7.0 5.7 1.3 8.9 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3072) FKBP_C PF00254.28 KOO35786.1 - 8.1e-21 74.2 0.0 1.5e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase P_C10 PF14974.6 KOO35786.1 - 3.1e-10 40.1 0.8 4.9e-10 39.4 0.8 1.3 1 0 0 1 1 1 1 Protein C10 FKBP_N PF01346.18 KOO35786.1 - 1.1e-08 35.9 0.8 4.2e-08 34.0 0.0 2.3 3 0 0 3 3 3 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Methyltransf_33 PF10017.9 KOO35787.1 - 5.3e-74 249.1 0.0 9.6e-74 248.3 0.0 1.3 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 KOO35787.1 - 3.7e-20 72.6 0.0 2.3e-19 70.0 0.0 2.0 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Glycos_transf_1 PF00534.20 KOO35787.1 - 4.2e-15 55.7 0.0 5.9e-14 52.0 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOO35787.1 - 3e-12 47.1 0.4 8.6e-12 45.6 0.4 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KOO35787.1 - 0.00022 21.6 0.1 0.00082 19.7 0.1 2.0 1 0 0 1 1 1 1 Glycosyl transferases group 1 CSD PF00313.22 KOO35788.1 - 2.9e-13 49.5 0.1 5.1e-13 48.7 0.1 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain PseudoU_synth_2 PF00849.22 KOO35788.1 - 0.00015 21.9 0.0 0.00022 21.4 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase AATase PF07247.12 KOO35789.1 - 0.0061 15.2 0.0 0.04 12.5 0.0 1.8 2 0 0 2 2 2 1 Alcohol acetyltransferase Condensation PF00668.20 KOO35790.1 - 0.0014 17.4 0.0 0.0014 17.4 0.0 1.0 1 0 0 1 1 1 1 Condensation domain XK-related PF09815.9 KOO35793.1 - 0.0011 18.1 6.1 0.0018 17.4 2.0 2.4 2 0 0 2 2 2 2 XK-related protein DUF2628 PF10947.8 KOO35793.1 - 0.5 10.7 0.1 0.5 10.7 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2628) Myotub-related PF06602.14 KOO35794.1 - 6.6e-66 222.6 0.0 8.4e-66 222.3 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Ribosomal_S25 PF03297.15 KOO35795.1 - 2.3e-38 130.4 4.3 2.5e-38 130.3 4.3 1.0 1 0 0 1 1 1 1 S25 ribosomal protein CorA PF01544.18 KOO35798.1 - 2.4e-19 69.7 0.0 3.5e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Arylsulfotrans PF05935.11 KOO35798.1 - 0.0093 14.9 0.0 0.021 13.7 0.0 1.5 2 0 0 2 2 2 1 Arylsulfotransferase (ASST) adh_short PF00106.25 KOO35799.1 - 8.7e-09 35.1 0.0 5.1e-07 29.3 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO35799.1 - 3.2e-06 26.9 0.0 7.3e-06 25.7 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Pyr_redox_2 PF07992.14 KOO35800.1 - 1.6e-37 129.3 0.0 1.9e-37 129.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO35800.1 - 3.8e-10 40.2 0.5 0.00022 21.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO35800.1 - 0.0011 18.6 1.3 7.4 6.0 0.0 3.2 3 0 0 3 3 3 3 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 KOO35800.1 - 0.0045 17.0 1.5 0.12 12.4 0.0 2.7 3 0 0 3 3 3 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 KOO35800.1 - 0.24 10.5 0.0 0.38 9.8 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) UBA PF00627.31 KOO35801.1 - 1.4e-06 28.1 0.3 5.6e-06 26.1 0.3 2.2 1 0 0 1 1 1 1 UBA/TS-N domain F-box PF00646.33 KOO35801.1 - 0.0013 18.5 1.1 0.0032 17.3 1.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOO35801.1 - 0.079 12.9 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 F-box-like Methyltransf_16 PF10294.9 KOO35802.1 - 8.8e-08 32.1 0.0 1.5e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 KOO35802.1 - 0.0015 19.2 0.1 0.0029 18.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain ZZ PF00569.17 KOO35802.1 - 0.032 14.0 0.1 0.072 12.9 0.0 1.6 2 0 0 2 2 2 0 Zinc finger, ZZ type Methyltransf_31 PF13847.6 KOO35802.1 - 0.048 13.5 0.1 0.073 12.9 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOO35802.1 - 0.07 12.7 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_11 PF08241.12 KOO35802.1 - 0.078 13.6 0.0 0.14 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 KOO35802.1 - 0.24 11.1 0.0 0.41 10.3 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Pkinase PF00069.25 KOO35803.1 - 3.4e-68 229.9 0.0 2.3e-66 223.9 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35803.1 - 7.6e-36 123.7 0.1 1.3e-34 119.7 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO35803.1 - 0.00013 21.4 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO35803.1 - 0.0011 18.4 0.0 0.0025 17.2 0.0 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family BTB PF00651.31 KOO35804.1 - 2.4e-18 66.4 0.1 6.9e-18 64.9 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 KOO35804.1 - 1e-12 48.1 0.5 2.2e-12 46.9 0.5 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch CCB2_CCB4 PF11152.8 KOO35805.1 - 1.9e-19 69.7 0.0 2.2e-19 69.5 0.0 1.0 1 0 0 1 1 1 1 Cofactor assembly of complex C subunit B, CCB2/CCB4 GAF_2 PF13185.6 KOO35805.1 - 0.0028 17.9 0.2 0.0055 17.0 0.1 1.6 1 1 0 1 1 1 1 GAF domain ACTL7A_N PF16840.5 KOO35805.1 - 0.085 12.9 0.2 0.24 11.5 0.1 1.8 2 0 0 2 2 2 0 Actin-like protein 7A N-terminus PAS_9 PF13426.7 KOO35806.1 - 3.2e-25 88.4 0.0 5.2e-13 49.2 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 KOO35806.1 - 6.3e-09 35.8 0.0 0.00041 20.3 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.12 KOO35806.1 - 1.9e-05 24.8 0.0 0.08 13.2 0.0 3.2 3 0 0 3 3 3 2 PAS fold PAS_4 PF08448.10 KOO35806.1 - 0.00015 22.0 0.0 0.034 14.4 0.0 2.9 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 KOO35806.1 - 0.0093 16.0 0.0 5.2 7.2 0.0 2.9 2 0 0 2 2 2 2 PAS domain Kinesin PF00225.23 KOO35807.1 - 3.1e-37 128.2 0.0 5.7e-34 117.5 0.2 2.1 2 0 0 2 2 2 2 Kinesin motor domain WW PF00397.26 KOO35807.1 - 6.5e-06 26.1 0.6 1.3e-05 25.2 0.6 1.5 1 0 0 1 1 1 1 WW domain RNase_PH PF01138.21 KOO35808.1 - 7.1e-25 88.0 0.1 1.1e-24 87.4 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOO35808.1 - 0.011 15.8 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 Pribosyltran PF00156.27 KOO35809.1 - 0.027 14.0 0.1 0.11 12.1 0.0 1.9 2 0 0 2 2 2 0 Phosphoribosyl transferase domain Syntaxin PF00804.25 KOO35810.1 - 4.7e-48 163.5 16.3 6.6e-48 163.0 16.3 1.2 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 KOO35810.1 - 8.4e-08 32.1 0.8 2.1e-07 30.8 0.1 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 KOO35810.1 - 6.2e-07 29.7 5.1 6.2e-07 29.7 5.1 2.2 2 0 0 2 2 2 1 Syntaxin-like protein RRF PF01765.19 KOO35810.1 - 0.0059 16.6 7.3 0.12 12.3 2.3 2.3 2 0 0 2 2 2 2 Ribosome recycling factor Nucleolin_bd PF16725.5 KOO35810.1 - 0.013 15.1 0.4 4.3 7.1 0.4 2.6 2 0 0 2 2 2 0 Nucleolin binding domain FapA PF03961.13 KOO35810.1 - 0.016 13.8 3.0 0.0099 14.5 1.2 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A VitD-bind_III PF09164.10 KOO35810.1 - 0.09 12.8 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Baculo_PEP_C PF04513.12 KOO35810.1 - 1.6 8.8 7.3 2.2 8.3 1.3 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus OmpH PF03938.14 KOO35810.1 - 2.3 8.6 13.6 8.1 6.8 11.3 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF948 PF06103.11 KOO35810.1 - 4.1 7.7 9.1 0.58 10.5 1.4 3.2 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF2115 PF09888.9 KOO35810.1 - 7.1 7.1 6.8 16 6.0 0.4 2.5 1 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) Pepdidase_M14_N PF18027.1 KOO35811.1 - 4.2e-11 43.2 0.1 8.3e-11 42.2 0.1 1.5 1 1 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 KOO35811.1 - 7.7e-10 39.0 0.0 1.2e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase MORN_2 PF07661.13 KOO35811.1 - 0.34 11.3 0.9 3.6 8.1 0.0 2.8 3 0 0 3 3 3 0 MORN repeat variant BACK PF07707.15 KOO35813.1 - 1.2e-18 67.1 0.1 1.8e-18 66.5 0.1 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 KOO35813.1 - 2e-07 31.2 0.0 3.4e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Agenet PF05641.12 KOO35814.1 - 0.0067 16.9 0.0 0.016 15.6 0.0 1.6 1 0 0 1 1 1 1 Agenet domain TUDOR_5 PF18359.1 KOO35814.1 - 0.066 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain 1 Fer4_13 PF13370.6 KOO35815.1 - 5.1e-12 46.2 5.9 1.9e-11 44.4 5.9 2.0 1 0 0 1 1 1 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 KOO35815.1 - 2.6e-07 31.3 3.9 2.6e-07 31.3 3.9 2.4 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_10 PF13237.6 KOO35815.1 - 6.8 6.9 12.3 23 5.2 6.2 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain EF-hand_6 PF13405.6 KOO35817.1 - 6.1e-18 63.2 4.6 5.9e-06 25.8 0.1 5.1 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 KOO35817.1 - 3.7e-16 57.4 2.7 9.8e-06 24.8 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO35817.1 - 5.2e-13 48.6 1.3 6.5e-08 32.3 0.2 3.8 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.6 KOO35817.1 - 1.6e-12 47.7 3.7 6.2e-09 36.2 1.3 3.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO35817.1 - 5.7e-08 31.9 11.7 0.00035 19.9 1.1 4.1 4 0 0 4 4 4 3 EF hand YqfQ PF14181.6 KOO35817.1 - 0.12 12.5 0.2 0.12 12.5 0.2 2.8 3 1 0 3 3 3 0 YqfQ-like protein WxL PF13731.6 KOO35817.1 - 0.37 10.8 3.0 1.4 8.9 3.0 2.0 1 0 0 1 1 1 0 WxL domain surface cell wall-binding Tecti-min-caps PF09300.10 KOO35818.1 - 0.021 14.9 0.1 0.055 13.5 0.1 1.6 1 0 0 1 1 1 0 Tectiviridae, minor capsid LRR_5 PF13306.6 KOO35821.1 - 1.2e-123 406.7 0.5 7.8e-46 155.2 0.0 3.4 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO35821.1 - 5.3e-19 67.7 0.0 0.067 13.0 0.0 8.0 2 2 8 10 10 10 8 Leucine rich repeat Peptidase_M8 PF01457.16 KOO35821.1 - 0.00053 18.8 7.2 13 4.3 0.0 5.7 1 1 7 8 8 8 3 Leishmanolysin Rep_1B PF17873.1 KOO35821.1 - 0.04 13.8 4.1 29 4.6 0.0 6.1 5 4 4 9 9 9 0 Replicase polyprotein 1ab KH_1 PF00013.29 KOO35824.1 - 1.1e-08 34.8 0.0 1.7e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 KOO35824.1 - 4.3e-05 23.3 0.0 7.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 KOO35824.1 - 0.0099 15.7 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 KH domain Helicase_C PF00271.31 KOO35825.1 - 2.3e-09 37.6 0.3 7e-09 36.0 0.3 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOO35825.1 - 5.2e-07 29.6 0.0 1.6e-06 28.0 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOO35825.1 - 0.001 19.4 0.2 0.019 15.2 0.1 3.1 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 KOO35825.1 - 0.0012 18.0 0.0 0.0029 16.7 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein Herpes_ori_bp PF02399.15 KOO35825.1 - 0.0015 16.7 0.0 0.014 13.5 0.0 2.2 3 0 0 3 3 3 1 Origin of replication binding protein PhoH PF02562.16 KOO35825.1 - 0.013 15.0 0.0 1.5 8.2 0.0 3.6 4 0 0 4 4 4 0 PhoH-like protein AAA_25 PF13481.6 KOO35825.1 - 0.049 13.2 0.1 0.17 11.4 0.1 2.0 1 1 0 1 1 1 0 AAA domain NUDIX PF00293.28 KOO35825.1 - 0.12 12.4 0.0 0.48 10.5 0.0 2.1 1 0 0 1 1 1 0 NUDIX domain PTCB-BRCT PF12738.7 KOO35825.1 - 0.19 11.7 0.5 7.8 6.5 0.0 2.5 2 0 0 2 2 2 0 twin BRCT domain Caps_synth_GfcC PF06251.11 KOO35825.1 - 1.5 8.4 4.1 0.82 9.3 0.3 2.4 3 0 0 3 3 3 0 Capsule biosynthesis GfcC HCNGP PF07818.13 KOO35827.1 - 8.9e-26 90.4 0.0 1.4e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 HCNGP-like protein Peptidase_C92 PF05708.12 KOO35829.1 - 4.4e-06 26.9 0.0 0.0019 18.3 0.0 2.3 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family DNA_ligase_IV PF11411.8 KOO35829.1 - 0.3 11.2 0.6 0.68 10.1 0.6 1.6 1 0 0 1 1 1 0 DNA ligase IV TetR_C_6 PF13977.6 KOO35829.1 - 0.6 10.4 6.9 0.076 13.2 1.2 2.4 3 0 0 3 3 3 0 BetI-type transcriptional repressor, C-terminal TIG PF01833.24 KOO35830.1 - 3.2e-49 164.9 0.0 1.4e-09 37.9 0.0 11.8 11 0 0 11 11 11 11 IPT/TIG domain TIG_plexin PF17960.1 KOO35830.1 - 5.7e-10 39.1 0.0 1.4 9.0 0.0 7.2 8 0 0 8 8 8 3 TIG domain LRRCT PF01463.24 KOO35830.1 - 8.9 7.1 6.7 27 5.6 0.1 4.5 4 0 0 4 4 4 0 Leucine rich repeat C-terminal domain Sel1 PF08238.12 KOO35831.1 - 0.00061 20.4 0.3 0.0033 18.1 0.1 2.1 2 0 0 2 2 2 1 Sel1 repeat CHD5 PF04420.14 KOO35832.1 - 0.099 12.5 6.7 0.15 11.9 3.0 2.3 2 0 0 2 2 2 0 CHD5-like protein Peptidase_S64 PF08192.11 KOO35832.1 - 0.18 10.3 2.1 0.22 9.9 2.1 1.2 1 0 0 1 1 1 0 Peptidase family S64 ING PF12998.7 KOO35832.1 - 0.18 12.4 5.9 3.9 8.1 0.2 3.0 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Baculo_PEP_C PF04513.12 KOO35832.1 - 1.2 9.2 8.7 0.36 10.9 0.8 3.3 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4200 PF13863.6 KOO35832.1 - 2.4 8.6 25.1 0.11 12.9 7.4 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4200) DUF5344 PF17279.2 KOO35832.1 - 2.5 8.7 8.0 3.3 8.4 1.8 3.6 2 2 2 4 4 4 0 Family of unknown function (DUF5344) Atg14 PF10186.9 KOO35832.1 - 3.9 6.5 15.0 0.26 10.3 0.5 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAM176 PF14851.6 KOO35832.1 - 8.6 6.0 12.9 3.9 7.1 3.5 2.6 3 0 0 3 3 3 0 FAM176 family LRR_6 PF13516.6 KOO35834.1 - 3.3e-18 64.1 19.5 0.00037 20.3 0.1 6.4 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 KOO35834.1 - 2.4e-05 24.6 6.0 0.14 12.6 0.6 3.6 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) DUF4030 PF13222.6 KOO35834.1 - 0.0084 16.3 0.0 2.3 8.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF4030) LRR_8 PF13855.6 KOO35834.1 - 0.015 15.1 10.9 4.1 7.2 0.8 4.8 1 1 3 4 4 4 0 Leucine rich repeat Arm-DNA-bind_1 PF09003.10 KOO35834.1 - 0.17 12.0 3.8 18 5.6 0.1 3.6 2 2 1 3 3 3 0 Bacteriophage lambda integrase, Arm DNA-binding domain HOASN PF14515.6 KOO35834.1 - 0.76 10.2 2.9 19 5.7 0.0 3.1 1 1 3 4 4 4 0 Haem-oxygenase-associated N-terminal helices Dpy-30 PF05186.13 KOO35835.1 - 0.014 15.0 0.1 0.032 13.9 0.1 1.5 1 0 0 1 1 1 0 Dpy-30 motif Arm PF00514.23 KOO35836.1 - 0.00048 20.1 5.1 1.6 8.9 0.0 3.3 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat Exo_endo_phos PF03372.23 KOO35838.1 - 0.016 14.7 0.0 0.042 13.4 0.0 1.7 1 1 1 2 2 2 0 Endonuclease/Exonuclease/phosphatase family Ribosomal_60s PF00428.19 KOO35840.1 - 0.068 13.8 3.2 0.12 13.0 3.2 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein TUDOR_5 PF18359.1 KOO35841.1 - 0.0064 16.2 0.0 0.014 15.0 0.0 1.6 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 ATP-synt_I PF03899.15 KOO35842.1 - 0.43 11.0 7.3 1.1 9.6 1.0 2.2 2 0 0 2 2 2 0 ATP synthase I chain ABC1 PF03109.16 KOO35843.1 - 6.2e-33 113.5 0.0 1e-32 112.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family MFS_1 PF07690.16 KOO35844.1 - 2.6e-20 72.7 45.8 2.7e-16 59.4 16.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 KOO35845.1 - 1.2e-56 192.0 0.0 2.2e-56 191.1 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35845.1 - 1.9e-31 109.3 0.0 2.4e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO35845.1 - 3.9e-05 23.1 0.0 5.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DSBA PF01323.20 KOO35846.1 - 3.2e-10 40.1 0.3 3.8e-10 39.9 0.3 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_5 PF13743.6 KOO35846.1 - 0.0013 18.5 0.0 0.0015 18.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DUF1525 PF07511.11 KOO35846.1 - 0.074 13.2 0.0 0.1 12.8 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1525) FHA PF00498.26 KOO35847.1 - 7.7e-15 55.0 0.1 1.1e-14 54.5 0.1 1.2 1 0 0 1 1 1 1 FHA domain FHA_2 PF17913.1 KOO35847.1 - 0.00014 22.0 0.0 0.00019 21.6 0.0 1.1 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO35847.1 - 0.009 16.3 0.1 0.013 15.8 0.1 1.2 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF2649 PF10854.8 KOO35848.1 - 0.0055 17.0 1.1 0.11 12.8 0.1 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2649) TIR_2 PF13676.6 KOO35849.1 - 1.9e-07 31.7 0.0 7.6e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 TIR domain YtxH PF12732.7 KOO35850.1 - 0.031 14.8 1.6 0.12 12.9 1.6 2.1 1 0 0 1 1 1 0 YtxH-like protein Apolipoprotein PF01442.18 KOO35850.1 - 0.04 13.8 11.9 0.042 13.7 5.8 2.4 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain HHH_2 PF12826.7 KOO35850.1 - 0.052 13.7 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif End3 PF12761.7 KOO35850.1 - 0.14 12.3 1.2 0.71 10.0 0.0 2.1 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF2203 PF09969.9 KOO35850.1 - 2.1 9.1 4.5 1.9 9.2 0.9 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) SSP160 PF06933.11 KOO35855.1 - 3.5 5.7 7.5 5.3 5.1 7.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 TilS PF09179.11 KOO35856.1 - 0.12 12.9 0.0 0.41 11.2 0.0 1.9 1 0 0 1 1 1 0 TilS substrate binding domain Coq4 PF05019.13 KOO35858.1 - 1.7e-64 217.2 0.0 2e-64 217.0 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 NADH_u_ox_C PF12853.7 KOO35858.1 - 0.05 13.6 0.0 0.082 12.9 0.0 1.3 1 0 0 1 1 1 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Pkinase PF00069.25 KOO35859.1 - 2.7e-25 89.2 0.0 5e-25 88.4 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35859.1 - 7.5e-14 51.6 0.0 3.4e-12 46.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO35859.1 - 5.5e-08 32.0 0.1 7.2e-08 31.6 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO35859.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KOO35859.1 - 0.057 12.4 0.2 0.096 11.6 0.2 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF819 PF05684.12 KOO35860.1 - 2.1e-09 36.9 0.1 2.1e-09 36.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF819) Tom5 PF10642.9 KOO35860.1 - 0.044 13.8 0.8 0.098 12.7 0.8 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase Hist_deacetyl PF00850.19 KOO35863.1 - 1e-52 179.6 0.0 1.4e-52 179.1 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Myb_DNA-binding PF00249.31 KOO35864.1 - 1.1e-22 80.0 0.9 2.7e-11 43.5 0.1 2.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO35864.1 - 1.8e-15 56.9 0.1 9.8e-07 28.9 0.1 2.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO35864.1 - 1.3e-08 34.6 0.0 0.00032 20.5 0.0 2.1 2 0 0 2 2 2 2 Myb DNA-binding like SANT_DAMP1_like PF16282.5 KOO35864.1 - 0.086 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 NAGLU PF05089.12 KOO35865.1 - 1.4e-121 405.5 4.2 2.1e-121 405.0 4.2 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 KOO35865.1 - 1.2e-56 192.2 1.8 2.1e-51 175.0 5.4 2.1 2 0 0 2 2 2 2 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 KOO35865.1 - 2.3e-09 36.9 0.0 6.4e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Dimer_Tnp_hAT PF05699.14 KOO35867.1 - 1.7e-05 24.5 0.2 2.5e-05 23.9 0.2 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region PX PF00787.24 KOO35868.1 - 2.4e-07 30.7 0.0 5.3e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 PX domain Med3 PF11593.8 KOO35868.1 - 4.1 6.5 20.8 6.2 5.9 20.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Glyoxalase PF00903.25 KOO35872.1 - 1.7e-07 31.4 0.0 2.2e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 KOO35872.1 - 9.5e-05 23.2 0.0 0.00012 22.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 KOO35872.1 - 0.11 12.8 0.0 0.4 11.0 0.0 1.8 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Hydrolase_3 PF08282.12 KOO35873.1 - 5.4e-38 131.2 0.0 6.1e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KOO35873.1 - 4.8e-09 36.1 0.0 6.4e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 KOO35873.1 - 0.0051 17.1 0.1 0.0094 16.3 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase 2OG-FeII_Oxy_3 PF13640.6 KOO35874.1 - 0.081 13.8 0.0 0.19 12.6 0.0 1.6 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily CHAT PF12770.7 KOO35875.1 - 1.1e-05 25.1 0.1 2.3e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 CHAT domain NACHT PF05729.12 KOO35875.1 - 2.8e-05 24.1 0.0 8.8e-05 22.5 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 KOO35875.1 - 2.9e-05 24.5 1.6 5.9e-05 23.5 0.3 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOO35875.1 - 0.0002 21.6 0.0 0.00056 20.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain LRR_6 PF13516.6 KOO35875.1 - 0.00029 20.6 0.5 0.39 10.9 0.1 2.9 2 0 0 2 2 2 2 Leucine Rich repeat AAA_19 PF13245.6 KOO35875.1 - 0.0043 17.4 0.0 0.0086 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain LRR_4 PF12799.7 KOO35875.1 - 0.0056 17.1 1.1 0.071 13.6 0.1 2.6 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) AAA_25 PF13481.6 KOO35875.1 - 0.0093 15.6 0.2 0.026 14.1 0.2 1.8 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 KOO35875.1 - 0.015 14.5 0.0 0.025 13.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain PhoH PF02562.16 KOO35875.1 - 0.026 14.0 0.0 0.047 13.1 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Tugs PF17840.1 KOO35875.1 - 0.1 12.8 0.3 0.28 11.4 0.3 1.8 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain Mito_carr PF00153.27 KOO35878.1 - 5.6e-34 116.0 2.9 5.8e-18 64.6 0.6 3.1 3 0 0 3 3 3 2 Mitochondrial carrier protein SpoVAB PF13782.6 KOO35878.1 - 0.87 9.9 3.9 2.1 8.7 0.2 2.8 2 1 1 3 3 3 0 Stage V sporulation protein AB TolA_bind_tri PF16331.5 KOO35879.1 - 0.014 15.4 6.8 0.014 15.4 6.8 3.7 3 1 1 4 4 4 0 TolA binding protein trimerisation GP3_package PF16677.5 KOO35879.1 - 0.029 14.5 0.0 12 6.0 0.0 3.2 2 1 0 2 2 2 0 DNA-packaging protein gp3 TAFH PF07531.14 KOO35879.1 - 0.066 13.3 0.8 0.36 11.0 0.2 2.6 3 0 0 3 3 3 0 NHR1 homology to TAF Nsp1_C PF05064.13 KOO35879.1 - 0.33 10.7 9.0 0.082 12.7 2.1 2.7 2 0 0 2 2 2 0 Nsp1-like C-terminal region Y_phosphatase PF00102.27 KOO35881.1 - 6.2e-08 32.5 0.0 7.8e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pkinase PF00069.25 KOO35882.1 - 9.3e-72 241.5 1.8 5.6e-63 212.8 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35882.1 - 6.4e-27 94.5 0.1 2.4e-23 82.8 0.0 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 KOO35882.1 - 0.021 13.8 0.0 0.092 11.7 0.0 2.1 1 1 0 1 1 1 0 Haspin like kinase domain PCI PF01399.27 KOO35883.1 - 8.1e-13 48.8 0.0 1.9e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 PCI domain Ras PF00071.22 KOO35885.1 - 1.7e-40 138.2 0.0 2.1e-40 138.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO35885.1 - 6.6e-32 110.3 0.0 9.9e-32 109.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO35885.1 - 4.4e-10 39.3 0.0 6.7e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOO35885.1 - 1.8e-05 24.8 0.0 3.5e-05 23.9 0.0 1.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOO35885.1 - 2.2e-05 23.9 0.0 2.6e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOO35885.1 - 3.9e-05 23.3 0.0 0.0034 17.0 0.0 2.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain YwhD PF08741.10 KOO35885.1 - 0.0049 16.6 0.0 0.0074 16.0 0.0 1.2 1 0 0 1 1 1 1 YwhD family TniB PF05621.11 KOO35885.1 - 0.052 12.9 0.0 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 KOO35885.1 - 0.085 13.2 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 KOO35885.1 - 0.15 12.0 0.0 1.9 8.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase DEC-1_N PF04625.13 KOO35885.1 - 0.19 10.7 0.9 0.25 10.3 0.9 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Beta_helix PF13229.6 KOO35886.1 - 7.2e-05 22.7 0.0 0.00012 22.0 0.0 1.3 1 0 0 1 1 1 1 Right handed beta helix region Pectinesterase PF01095.19 KOO35886.1 - 0.021 13.5 0.2 0.064 11.9 0.2 1.6 1 1 1 2 2 2 0 Pectinesterase NosD PF05048.13 KOO35886.1 - 0.13 11.5 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) PH PF00169.29 KOO35889.1 - 0.005 17.3 0.0 0.0093 16.5 0.0 1.4 1 0 0 1 1 1 1 PH domain Fez1 PF06818.15 KOO35889.1 - 0.0094 16.4 8.3 0.016 15.7 8.3 1.3 1 0 0 1 1 1 1 Fez1 IQ PF00612.27 KOO35889.1 - 0.014 15.1 1.7 1 9.3 0.3 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif HAUS-augmin3 PF14932.6 KOO35889.1 - 0.026 14.1 1.4 0.026 14.1 1.4 1.8 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 RasGAP_C PF03836.15 KOO35889.1 - 0.33 11.1 5.3 0.53 10.4 5.3 1.3 1 0 0 1 1 1 0 RasGAP C-terminus ADIP PF11559.8 KOO35889.1 - 1.2 9.2 13.7 0.19 11.8 5.4 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 KOO35889.1 - 1.7 7.4 11.7 0.081 11.8 2.4 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein APG6_N PF17675.1 KOO35889.1 - 4.8 7.7 14.0 0.57 10.7 6.7 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region ERM PF00769.19 KOO35889.1 - 6.9 6.4 18.7 0.76 9.6 8.1 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Glyco_hydro_16 PF00722.21 KOO35890.1 - 9.5e-06 25.2 0.0 6.2e-05 22.5 0.0 2.2 3 0 0 3 3 3 1 Glycosyl hydrolases family 16 Fe_hyd_lg_C PF02906.14 KOO35891.1 - 2.3e-39 135.5 0.0 3.8e-39 134.8 0.0 1.3 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.17 KOO35891.1 - 4.5e-06 26.6 0.0 6.8e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Iron hydrogenase small subunit MAAL_C PF07476.11 KOO35892.1 - 0.077 12.1 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Laminin_G_3 PF13385.6 KOO35893.1 - 0.018 15.2 0.1 0.024 14.8 0.1 1.3 1 1 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily ArfGap PF01412.18 KOO35897.1 - 1e-25 90.1 0.0 2.2e-25 89.0 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf HBS1_N PF08938.10 KOO35897.1 - 0.14 12.5 3.1 0.096 13.0 0.8 1.9 2 0 0 2 2 2 0 HBS1 N-terminus Cep57_MT_bd PF06657.13 KOO35898.1 - 0.04 14.4 7.2 4.9 7.7 6.6 2.5 1 1 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF1700 PF08006.11 KOO35898.1 - 0.042 13.4 0.1 0.06 12.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF3450 PF11932.8 KOO35898.1 - 0.048 13.0 4.7 0.062 12.6 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) MCU PF04678.13 KOO35898.1 - 0.061 13.4 0.5 0.089 12.9 0.5 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter CdvA PF18822.1 KOO35898.1 - 0.092 12.6 7.6 0.91 9.4 3.2 2.2 1 1 1 2 2 2 0 CdvA-like coiled-coil domain Uso1_p115_C PF04871.13 KOO35898.1 - 0.094 13.1 10.5 0.14 12.5 10.5 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Baculo_PEP_C PF04513.12 KOO35898.1 - 0.14 12.2 4.3 0.2 11.7 4.3 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 KOO35898.1 - 0.23 10.3 5.8 0.28 10.0 5.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein O-FucT PF10250.9 KOO35901.1 - 0.022 14.5 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase DUF2309 PF10070.9 KOO35903.1 - 1.1e-131 440.7 0.0 1.3e-131 440.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2309) Cpn60_TCP1 PF00118.24 KOO35905.1 - 6.4e-146 486.8 10.3 7.2e-146 486.7 10.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dak2 PF02734.17 KOO35905.1 - 0.035 14.0 0.8 0.76 9.7 0.1 2.6 2 0 0 2 2 2 0 DAK2 domain YbaB_DNA_bd PF02575.16 KOO35905.1 - 1.5 9.1 5.2 0.93 9.8 0.3 3.0 2 1 0 2 2 2 0 YbaB/EbfC DNA-binding family DUF4336 PF14234.6 KOO35906.1 - 7.3e-67 225.8 0.0 1.2e-54 185.7 0.0 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4336) VRR_NUC PF08774.11 KOO35906.1 - 4.2e-17 62.2 0.0 7.1e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 VRR-NUC domain DUF1937 PF09152.10 KOO35907.1 - 0.1 13.4 0.1 9.1 7.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1937) PAPS_reduct PF01507.19 KOO35907.1 - 0.14 12.2 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family bact-PGI_C PF10432.9 KOO35907.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal SIS domain CH PF00307.31 KOO35908.1 - 8.1e-35 119.3 0.6 6.4e-20 71.4 0.0 3.0 3 0 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KOO35908.1 - 4.7e-10 39.2 0.0 1e-05 25.3 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain Tae4 PF14113.6 KOO35908.1 - 0.024 14.9 0.2 11 6.2 0.1 2.6 2 0 0 2 2 2 0 Type VI secretion system (T6SS), amidase effector protein 4 Spectrin PF00435.21 KOO35908.1 - 0.057 13.9 0.6 11 6.5 0.2 2.9 2 0 0 2 2 2 0 Spectrin repeat Phage_integrase PF00589.22 KOO35909.1 - 8.8e-05 22.4 0.0 0.001 18.9 0.0 2.2 2 0 0 2 2 2 1 Phage integrase family zf-H2C2_2 PF13465.6 KOO35911.1 - 6.4e-31 105.4 41.2 5.2e-05 23.5 0.3 8.5 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.26 KOO35911.1 - 4.3e-14 52.1 43.8 0.047 14.2 1.1 7.6 7 0 0 7 7 7 7 Zinc finger, C2H2 type OTU PF02338.19 KOO35911.1 - 2.7e-08 34.3 0.0 6.6e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 OTU-like cysteine protease zf-C2H2_4 PF13894.6 KOO35911.1 - 2.1e-06 28.1 42.9 0.1 13.5 0.1 7.7 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOO35911.1 - 0.014 15.4 0.5 0.014 15.4 0.5 6.6 8 0 0 8 8 8 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOO35911.1 - 0.13 12.5 8.0 6.6 7.1 0.0 4.9 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding Microvir_lysis PF04517.12 KOO35911.1 - 0.63 10.0 2.2 1.2e+02 2.7 0.0 3.6 3 0 0 3 3 3 0 Microvirus lysis protein (E), C terminus VHL_C PF17211.3 KOO35912.1 - 0.012 15.7 18.4 0.67 10.0 0.1 6.2 7 0 0 7 7 7 0 VHL box domain T2SSM_b PF10741.9 KOO35912.1 - 0.013 15.3 14.9 12 5.7 0.2 6.2 1 1 6 7 7 7 0 Type II secretion system (T2SS), protein M subtype b zf-His_Me_endon PF05551.11 KOO35912.1 - 0.57 10.4 2.1 76 3.5 0.0 3.0 1 1 1 3 3 3 0 Zinc-binding loop region of homing endonuclease DUF1160 PF06648.11 KOO35913.1 - 0.021 14.8 0.1 0.043 13.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) DUF3446 PF11928.8 KOO35913.1 - 0.063 13.6 1.2 0.42 11.0 1.2 2.4 1 0 0 1 1 1 0 Early growth response N-terminal domain TFCD_C PF12612.8 KOO35913.1 - 0.14 12.0 0.3 1.8 8.3 0.1 2.9 3 0 0 3 3 3 0 Tubulin folding cofactor D C terminal DUF3084 PF11283.8 KOO35914.1 - 1.2 9.2 9.3 1.7 8.6 2.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3084) Apolipoprotein PF01442.18 KOO35915.1 - 0.04 13.8 15.8 4.4 7.1 15.7 2.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain CBM-like PF14683.6 KOO35916.1 - 0.049 13.5 1.6 6.8 6.5 0.1 2.2 2 0 0 2 2 2 0 Polysaccharide lyase family 4, domain III GAS PF13851.6 KOO35916.1 - 0.11 11.9 11.3 0.32 10.3 1.6 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 KOO35916.1 - 6.6 7.1 15.5 3.9 7.9 7.3 2.2 2 0 0 2 2 2 0 Fez1 2OG-FeII_Oxy_3 PF13640.6 KOO35917.1 - 0.00015 22.6 0.1 0.00026 21.8 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PepSY_2 PF13670.6 KOO35919.1 - 0.018 15.0 1.1 0.03 14.3 1.1 1.3 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain EF-hand_1 PF00036.32 KOO35921.1 - 0.001 18.4 0.5 0.092 12.3 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO35921.1 - 0.0013 18.5 0.1 0.088 12.8 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 KOO35921.1 - 0.14 12.0 0.0 18 5.3 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 KOO35921.1 - 1 9.0 3.6 0.38 10.3 0.2 2.0 2 0 0 2 2 2 0 EF hand Form_Nir_trans PF01226.17 KOO35922.1 - 7e-58 195.8 20.5 8e-58 195.6 20.5 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter MFS_1 PF07690.16 KOO35923.1 - 6.7e-10 38.4 71.0 2.3e-08 33.3 46.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily NEMP PF10225.9 KOO35923.1 - 0.85 9.2 5.7 1.7 8.2 5.7 1.5 1 0 0 1 1 1 0 NEMP family DivIC PF04977.15 KOO35924.1 - 2.1 8.2 39.2 0.39 10.5 5.4 4.7 1 1 2 4 4 4 0 Septum formation initiator DUF4281 PF14108.6 KOO35925.1 - 3.3e-28 98.6 0.7 3.8e-28 98.4 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4281) Pkinase PF00069.25 KOO35926.1 - 3e-44 151.4 0.0 1.1e-43 149.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO35926.1 - 1.5e-18 67.0 0.0 2.1e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO35926.1 - 0.052 12.9 0.0 0.092 12.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Polyoma_agno PF01736.16 KOO35928.1 - 1.9 8.3 10.0 2.3 8.0 2.2 3.4 3 0 0 3 3 3 0 Polyomavirus agnoprotein CREPT PF16566.5 KOO35929.1 - 0.012 15.8 0.5 0.012 15.8 0.5 2.5 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4201 PF13870.6 KOO35929.1 - 0.016 14.9 9.1 0.018 14.8 7.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF3584 PF12128.8 KOO35929.1 - 0.041 11.4 9.5 0.049 11.2 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) RasGAP_C PF03836.15 KOO35929.1 - 0.058 13.5 1.0 0.21 11.7 0.4 2.1 1 1 1 2 2 2 0 RasGAP C-terminus FAM167 PF11652.8 KOO35929.1 - 0.13 12.7 3.2 0.44 11.1 0.3 2.3 1 1 0 2 2 2 0 FAM167 IBB PF01749.20 KOO35929.1 - 0.23 11.9 4.7 0.76 10.3 4.7 1.8 1 1 0 1 1 1 0 Importin beta binding domain V_ATPase_I PF01496.19 KOO35929.1 - 1.5 6.7 3.0 1.7 6.5 3.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ADIP PF11559.8 KOO35929.1 - 1.8 8.6 12.0 0.11 12.5 5.5 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 KOO35929.1 - 2.4 8.9 6.6 2.9 8.6 2.9 2.4 1 1 1 2 2 2 0 Initiation control protein YabA Exonuc_VII_L PF02601.15 KOO35929.1 - 3 7.3 9.6 3.8 7.0 9.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2807 PF10988.8 KOO35931.1 - 0.0016 18.3 8.7 0.025 14.4 6.3 3.0 1 1 1 2 2 2 1 Putative auto-transporter adhesin, head GIN domain DUF4097 PF13349.6 KOO35931.1 - 0.0032 16.9 0.5 0.007 15.7 0.5 1.5 1 1 0 1 1 1 1 Putative adhesin SoxE PF06525.11 KOO35931.1 - 0.1 12.0 0.1 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 Sulfocyanin (SoxE) domain Chorion_1 PF01723.16 KOO35931.1 - 0.44 10.5 9.4 0.037 14.0 1.2 2.3 1 1 0 2 2 2 0 Chorion protein SPO22 PF08631.10 KOO35932.1 - 0.0033 17.0 10.1 0.49 9.8 0.2 3.7 2 2 2 4 4 4 2 Meiosis protein SPO22/ZIP4 like TPR_1 PF00515.28 KOO35932.1 - 0.0045 16.7 0.1 11 6.1 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO35932.1 - 0.0051 17.3 14.4 1.2 9.6 0.0 6.2 6 1 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO35932.1 - 0.06 13.6 1.2 1.1 9.5 0.0 3.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 KOO35932.1 - 0.063 13.9 6.2 9.6 7.0 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO35932.1 - 2.9 8.2 15.2 0.57 10.5 1.1 5.4 6 1 0 6 6 6 0 Tetratricopeptide repeat Profilin PF00235.19 KOO35933.1 - 3.6e-37 127.5 0.2 4e-37 127.3 0.2 1.0 1 0 0 1 1 1 1 Profilin cNMP_binding PF00027.29 KOO35934.1 - 2.1e-08 34.1 0.0 0.021 14.9 0.0 3.3 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Peptidase_S51 PF03575.17 KOO35934.1 - 0.0059 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S51 Nefa_Nip30_N PF10187.9 KOO35935.1 - 3.7e-14 52.9 10.8 5.8e-14 52.3 10.8 1.3 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Rrn6 PF10214.9 KOO35935.1 - 0.06 11.8 2.8 0.068 11.7 2.8 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor U79_P34 PF03064.16 KOO35935.1 - 5.5 6.3 7.5 7.9 5.8 7.5 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Rubis-subs-bind PF09273.11 KOO35936.1 - 3.8e-23 82.6 0.2 1e-22 81.2 0.2 1.8 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 KOO35936.1 - 1.3e-15 58.2 0.0 2.2e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 SET domain Ufd2P_core PF10408.9 KOO35937.1 - 1.6e-158 529.2 0.0 2e-158 528.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 KOO35937.1 - 4.4e-27 94.1 0.1 9.1e-27 93.0 0.1 1.6 1 0 0 1 1 1 1 U-box domain PBC PF03792.13 KOO35937.1 - 0.035 13.9 1.8 0.72 9.6 0.5 3.0 2 1 1 3 3 3 0 PBC domain ComX PF05952.12 KOO35937.1 - 0.24 11.4 0.3 1.2 9.2 0.0 2.3 3 0 0 3 3 3 0 Bacillus competence pheromone ComX DAGAT PF03982.13 KOO35939.1 - 1.8e-23 83.0 0.0 2.6e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.21 KOO35939.1 - 0.023 14.3 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Acyltransferase TylF PF05711.11 KOO35940.1 - 3.7e-30 105.0 0.0 1.7e-21 76.7 0.0 2.1 1 1 1 2 2 2 2 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 KOO35940.1 - 0.00031 21.7 0.0 0.00056 20.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain EF-hand_7 PF13499.6 KOO35941.1 - 1.3e-07 31.9 0.0 6.4e-07 29.7 0.0 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO35941.1 - 2.2e-05 24.0 0.1 0.051 13.5 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain DUF4378 PF14309.6 KOO35941.1 - 0.0055 17.1 0.0 0.0096 16.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4378) EF-hand_1 PF00036.32 KOO35941.1 - 0.0067 15.9 0.1 0.095 12.3 0.0 2.9 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO35941.1 - 0.012 15.1 0.0 0.052 13.1 0.0 2.1 1 0 0 1 1 1 0 EF hand Oxidored-like PF09791.9 KOO35941.1 - 0.034 13.8 0.6 0.077 12.7 0.6 1.5 1 0 0 1 1 1 0 Oxidoreductase-like protein, N-terminal Peptidase_S8 PF00082.22 KOO35942.1 - 1.9e-22 79.9 0.9 2.8e-22 79.4 0.9 1.1 1 0 0 1 1 1 1 Subtilase family Phage_tail_S PF05069.13 KOO35944.1 - 0.011 15.6 0.3 0.016 15.0 0.3 1.3 1 0 0 1 1 1 0 Phage virion morphogenesis family CDC45 PF02724.14 KOO35944.1 - 0.021 13.2 0.4 0.027 12.8 0.4 1.1 1 0 0 1 1 1 0 CDC45-like protein O-FucT PF10250.9 KOO35945.1 - 0.027 14.2 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase USP8_dimer PF08969.11 KOO35947.1 - 1.6e-13 50.8 0.0 2.2e-13 50.4 0.0 1.2 1 1 0 1 1 1 1 USP8 dimerisation domain NAP PF00956.18 KOO35948.1 - 4.9e-55 186.6 9.1 3.9e-49 167.3 0.7 2.2 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) BTHB PF18410.1 KOO35948.1 - 1.1e-25 89.3 0.0 2.6e-25 88.0 0.0 1.6 1 0 0 1 1 1 1 Basic tilted helix bundle domain SbcCD_C PF13558.6 KOO35948.1 - 0.022 15.0 0.0 0.052 13.8 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit bZIP_1 PF00170.21 KOO35948.1 - 0.042 14.0 3.4 0.17 12.0 3.4 2.0 1 0 0 1 1 1 0 bZIP transcription factor DUF848 PF05852.11 KOO35948.1 - 0.067 13.3 1.0 0.12 12.4 1.0 1.4 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DMAP_binding PF06464.11 KOO35948.1 - 0.12 13.2 2.8 1.4 9.8 1.5 2.6 2 0 0 2 2 2 0 DMAP1-binding Domain DUF4407 PF14362.6 KOO35948.1 - 0.12 11.7 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mst1_SARAH PF11629.8 KOO35948.1 - 0.17 12.0 2.5 0.53 10.4 2.5 1.8 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 DUF3924 PF13062.6 KOO35948.1 - 6.3 6.8 6.0 8.4 6.4 3.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3924) Aldo_ket_red PF00248.21 KOO35949.1 - 9.2e-14 51.3 0.1 1.9e-11 43.7 0.1 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family PRRSV_Env PF02340.15 KOO35949.1 - 0.21 11.0 1.3 0.8 9.0 1.2 1.9 2 0 0 2 2 2 0 PRRSV putative envelope protein DUF2828 PF11443.8 KOO35950.1 - 1.1e-25 89.8 3.2 5.8e-16 57.7 1.0 3.7 2 1 1 3 3 3 3 Domain of unknown function (DUF2828) XPA_C PF05181.12 KOO35951.1 - 0.029 14.3 0.1 0.075 13.0 0.1 1.6 1 0 0 1 1 1 0 XPA protein C-terminus LRR_8 PF13855.6 KOO35952.1 - 1.5e-16 59.9 11.3 1.2e-08 34.6 2.6 3.9 4 0 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 KOO35952.1 - 4.2e-06 27.0 18.3 0.005 17.2 4.1 5.1 4 2 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO35952.1 - 0.0019 18.5 11.3 1.5 9.7 0.1 7.0 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_6 PF13516.6 KOO35952.1 - 0.0031 17.5 13.6 1 9.6 0.1 5.9 7 0 0 7 7 7 2 Leucine Rich repeat Kelch_5 PF13854.6 KOO35953.1 - 2.8e-24 84.6 0.0 0.0019 18.2 0.0 6.6 6 1 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KOO35953.1 - 4.4e-20 71.5 9.3 0.00034 20.8 0.6 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO35953.1 - 4.9e-15 55.3 0.8 0.015 15.3 0.1 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain TPR_2 PF07719.17 KOO35953.1 - 2.8e-13 48.9 4.3 1.9e-05 24.4 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO35953.1 - 6.9e-12 44.7 2.5 0.00037 20.2 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat Kelch_2 PF07646.15 KOO35953.1 - 1.5e-09 37.4 0.0 0.37 10.8 0.0 5.9 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 KOO35953.1 - 2.8e-08 33.8 0.0 7.6 7.0 0.0 6.3 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 KOO35953.1 - 2.8e-06 26.8 1.0 14 5.4 0.0 6.4 7 0 0 7 7 7 0 Kelch motif TPR_16 PF13432.6 KOO35953.1 - 5.7e-05 23.7 5.7 5.7e-05 23.7 5.7 4.3 3 1 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO35953.1 - 0.00016 21.3 6.6 0.025 14.3 1.7 3.3 2 1 1 3 3 3 2 TPR repeat TPR_14 PF13428.6 KOO35953.1 - 0.00019 22.0 0.9 0.00019 22.0 0.9 4.5 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO35953.1 - 0.00067 19.7 1.6 0.047 13.9 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO35953.1 - 0.00091 19.4 1.4 0.83 10.2 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO35953.1 - 0.0024 18.0 5.2 0.015 15.4 2.2 2.9 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO35953.1 - 0.0027 18.2 2.1 0.0027 18.2 2.1 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO35953.1 - 0.012 15.6 0.1 9.2 6.6 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.17 KOO35953.1 - 2.1 8.8 12.1 0.16 12.4 2.2 3.1 1 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_12 PF13424.6 KOO35953.1 - 7.2 7.0 14.6 5.5 7.4 2.3 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO35953.1 - 8.8 6.3 9.2 60 3.7 0.1 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat ARL2_Bind_BART PF11527.8 KOO35954.1 - 1e-13 51.4 0.0 1.4e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART LRR_6 PF13516.6 KOO35955.1 - 6.7e-11 41.3 1.0 0.3 11.2 0.0 5.0 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.7 KOO35955.1 - 0.15 12.6 0.1 2.8 8.5 0.1 2.8 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) TMEM237 PF15383.6 KOO35956.1 - 0.017 14.2 0.6 0.75 8.8 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 237 COG2 PF06148.11 KOO35957.1 - 0.0086 16.2 4.4 0.028 14.5 3.2 2.0 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 FANCI_S4 PF14678.6 KOO35957.1 - 0.026 13.7 1.0 0.031 13.4 1.0 1.1 1 0 0 1 1 1 0 FANCI solenoid 4 Uds1 PF15456.6 KOO35957.1 - 0.061 13.5 13.2 0.033 14.3 2.4 2.1 1 1 1 2 2 2 0 Up-regulated During Septation TMF_DNA_bd PF12329.8 KOO35957.1 - 0.3 11.1 10.0 0.95 9.5 8.9 2.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding YlqD PF11068.8 KOO35957.1 - 0.63 10.4 5.6 1 9.7 5.6 1.3 1 0 0 1 1 1 0 YlqD protein Tropomyosin PF00261.20 KOO35957.1 - 1.2 8.4 18.7 0.51 9.7 15.6 1.8 1 1 1 2 2 2 0 Tropomyosin HR1 PF02185.16 KOO35957.1 - 3.2 7.9 11.7 8.9 6.5 5.7 3.0 2 1 1 3 3 3 0 Hr1 repeat DASH_Hsk3 PF08227.11 KOO35957.1 - 3.4 8.1 8.1 4 7.9 0.1 3.3 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like DEAD PF00270.29 KOO35958.1 - 2e-05 24.4 2.9 0.035 13.9 0.2 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 KOO35958.1 - 0.00017 21.6 0.4 0.59 10.1 0.2 2.5 1 1 1 2 2 2 2 Type III restriction enzyme, res subunit T2SSE PF00437.20 KOO35958.1 - 0.053 12.6 4.0 3.4 6.6 0.5 2.2 1 1 1 2 2 2 0 Type II/IV secretion system protein AAA_22 PF13401.6 KOO35958.1 - 0.067 13.5 1.2 4.8 7.5 0.1 2.7 1 1 1 2 2 2 0 AAA domain RPS31 PF17067.5 KOO35958.1 - 2.1 8.6 4.3 2.1 8.5 0.0 2.8 2 1 1 3 3 3 0 Ribosomal protein S31e Chloroa_b-bind PF00504.21 KOO35960.1 - 1.2e-30 107.2 0.1 1.6e-30 106.8 0.1 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Sulfotransfer_3 PF13469.6 KOO35961.1 - 2.1e-33 116.5 0.0 5.4e-33 115.2 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO35961.1 - 1e-05 25.1 0.0 9e-05 22.1 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_4 PF17784.1 KOO35961.1 - 0.058 13.2 0.1 7.2 6.4 0.0 2.5 2 0 0 2 2 2 0 Sulfotransferase domain CaATP_NAI PF12515.8 KOO35961.1 - 0.31 10.7 0.1 0.31 10.7 0.1 2.1 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain Chloroa_b-bind PF00504.21 KOO35962.1 - 1.7e-33 116.4 0.1 2e-33 116.2 0.1 1.0 1 0 0 1 1 1 1 Chlorophyll A-B binding protein EF-hand_5 PF13202.6 KOO35963.1 - 5.5e-07 28.8 1.9 0.00075 18.9 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 KOO35963.1 - 7.6e-06 25.1 1.5 0.007 15.8 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO35963.1 - 0.00028 21.3 1.4 0.55 10.7 0.0 2.7 1 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO35963.1 - 0.0017 18.1 3.8 0.087 12.8 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO35963.1 - 0.0033 17.2 0.1 0.084 12.7 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO35963.1 - 0.0069 16.7 0.2 1.8 8.9 0.0 2.6 1 1 2 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_7 PF13499.6 KOO35964.1 - 3.9e-08 33.6 1.2 0.00073 19.9 0.1 2.2 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO35964.1 - 3.3e-07 29.4 0.0 0.0046 16.4 0.0 2.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO35964.1 - 1.3e-05 24.8 0.0 0.018 14.9 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO35964.1 - 0.0015 18.0 1.3 0.31 10.6 0.0 2.7 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 KOO35964.1 - 0.0015 18.8 0.0 0.023 15.0 0.0 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KOO35964.1 - 0.0049 16.7 0.0 1.9 8.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair CTD_bind PF04818.13 KOO35965.1 - 5.8e-06 27.0 0.0 1.8e-05 25.4 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. DUF2514 PF10721.9 KOO35965.1 - 0.025 14.6 5.1 0.054 13.5 5.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Pro_isomerase PF00160.21 KOO35966.1 - 4e-45 153.9 0.0 5.9e-45 153.4 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FKBP_C PF00254.28 KOO35966.1 - 1.7e-22 79.5 0.0 3.1e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 KOO35966.1 - 6.6e-06 27.0 0.0 1.2e-05 26.1 0.0 1.4 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Mg_trans_NIPA PF05653.14 KOO35967.1 - 2.8e-09 36.5 13.5 4.1e-09 36.0 13.5 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KOO35967.1 - 0.0063 16.7 2.0 0.0063 16.7 2.0 3.4 2 1 1 3 3 3 1 EamA-like transporter family DUF4232 PF14016.6 KOO35968.1 - 0.013 15.7 0.7 0.041 14.0 0.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4232) Tic110 PF16940.5 KOO35968.1 - 1.2 7.5 2.2 1.6 7.1 2.2 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter RNase_PH PF01138.21 KOO35969.1 - 6e-19 68.8 0.1 6e-19 68.8 0.1 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOO35969.1 - 0.13 12.3 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 Aminotran_1_2 PF00155.21 KOO35970.1 - 2.7e-36 125.5 0.0 3.6e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II PX PF00787.24 KOO35970.1 - 1.5e-05 25.0 0.0 2.7e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 PX domain Alliinase_C PF04864.13 KOO35970.1 - 0.03 13.2 0.0 0.1 11.4 0.0 1.8 2 0 0 2 2 2 0 Allinase PUA_3 PF17785.1 KOO35971.1 - 2.9e-15 55.8 0.0 5.4e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 PUA-like domain Methyltrans_SAM PF10672.9 KOO35971.1 - 6.4e-15 55.1 0.0 2.2e-14 53.3 0.0 1.7 1 1 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Methyltransf_31 PF13847.6 KOO35971.1 - 7.2e-11 42.1 0.0 1.2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO35971.1 - 1.3e-07 32.3 0.1 4.1e-07 30.6 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO35971.1 - 7.8e-07 28.8 0.0 1.2e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 KOO35971.1 - 2.4e-05 24.1 0.2 0.00011 21.9 0.2 2.0 1 1 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 KOO35971.1 - 3.2e-05 23.6 0.0 0.00069 19.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 KOO35971.1 - 0.00049 19.8 0.0 0.0096 15.6 0.0 2.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 FtsJ PF01728.19 KOO35971.1 - 0.00054 20.1 0.0 0.00089 19.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Met_10 PF02475.16 KOO35971.1 - 0.00078 19.2 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 KOO35971.1 - 0.0011 18.6 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 KOO35971.1 - 0.0011 19.5 0.3 0.023 15.3 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO35971.1 - 0.035 13.9 0.0 0.12 12.3 0.1 1.8 1 1 0 1 1 1 0 Methyltransferase domain MAGI_u5 PF16666.5 KOO35971.1 - 0.46 10.6 3.8 1 9.5 3.8 1.5 1 0 0 1 1 1 0 Unstructured region on MAGI PhyH PF05721.13 KOO35972.1 - 1.4e-14 54.9 0.1 2.4e-14 54.1 0.1 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 KOO35972.1 - 0.00045 20.6 0.0 0.00094 19.6 0.0 1.5 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase VCBS PF13517.6 KOO35974.1 - 7.5e-131 426.8 145.8 2.5e-14 53.6 5.5 12.7 1 1 12 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO35974.1 - 3.6e-63 209.2 122.9 4.6e-05 23.4 0.5 13.4 13 0 0 13 13 13 13 FG-GAP repeat Pkinase_Tyr PF07714.17 KOO35974.1 - 4.3e-26 91.8 0.0 5.2e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO35974.1 - 6.5e-26 91.3 0.0 3.6e-12 46.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain TM_PBP2_N PF16296.5 KOO35974.1 - 9.1e-09 35.3 0.0 35 4.6 0.0 9.2 11 0 0 11 11 11 0 N-terminal of TM subunit in PBP-dependent ABC transporters Dockerin_1 PF00404.18 KOO35974.1 - 1.4e-06 28.4 40.4 17 5.7 0.1 12.6 13 0 0 13 13 13 1 Dockerin type I domain TcdB_toxin_midN PF12256.8 KOO35974.1 - 0.00014 21.3 51.1 10 5.4 0.1 12.5 9 3 4 13 13 13 4 Insecticide toxin TcdB middle/N-terminal region T4BSS_DotH_IcmK PF12293.8 KOO35974.1 - 0.0048 16.2 0.0 35 3.5 0.0 5.7 2 2 3 7 7 7 0 Putative outer membrane core complex of type IVb secretion Arrestin_N PF00339.29 KOO35974.1 - 0.1 12.7 0.1 74 3.4 0.0 5.1 8 0 0 8 8 8 0 Arrestin (or S-antigen), N-terminal domain PGG PF13962.6 KOO35974.1 - 0.42 10.5 4.5 4.5 7.1 0.0 4.5 6 0 0 6 6 6 0 Domain of unknown function AAA_30 PF13604.6 KOO35976.1 - 3.1e-08 33.6 0.1 3.1e-08 33.6 0.1 3.8 3 1 0 3 3 3 1 AAA domain PIF1 PF05970.14 KOO35976.1 - 7.5e-08 31.9 0.7 9.7e-07 28.3 0.1 2.5 2 1 0 2 2 2 1 PIF1-like helicase AAA_19 PF13245.6 KOO35976.1 - 2.7e-05 24.5 0.1 0.00034 21.0 0.1 2.7 2 1 0 2 2 2 1 AAA domain SNF2_N PF00176.23 KOO35978.1 - 6.3e-61 206.0 0.1 1e-60 205.3 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO35978.1 - 2.2e-18 66.6 0.0 5.6e-18 65.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 KOO35978.1 - 1.3e-10 41.0 0.2 1.3e-10 41.0 0.2 2.9 4 0 0 4 4 4 1 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 KOO35978.1 - 1.2e-09 38.4 0.0 2.9e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO35978.1 - 0.0028 17.4 0.0 0.0064 16.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 KOO35978.1 - 0.025 13.8 0.0 0.052 12.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SWI2_SNF2 PF18766.1 KOO35978.1 - 0.036 13.7 0.0 0.069 12.8 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase TIG PF01833.24 KOO35979.1 - 3.3e-80 264.2 29.0 4.7e-07 29.8 0.1 18.2 17 2 0 17 17 17 15 IPT/TIG domain TIG_plexin PF17960.1 KOO35979.1 - 5.7e-34 116.0 0.0 0.0018 18.2 0.0 14.7 16 0 0 16 16 16 7 TIG domain C2 PF00168.30 KOO35979.1 - 2.6e-33 114.4 0.0 7.4e-16 58.3 0.0 2.4 2 0 0 2 2 2 2 C2 domain Anth_Ig PF05587.13 KOO35979.1 - 2.9e-08 34.0 0.0 0.84 10.0 0.0 7.0 8 0 0 8 8 8 2 Anthrax receptor extracellular domain BNR PF02012.20 KOO35979.1 - 0.14 12.2 18.7 3.2 8.1 0.0 6.5 6 0 0 6 6 6 0 BNR/Asp-box repeat Qn_am_d_aIII PF09099.10 KOO35979.1 - 0.17 12.3 3.8 5 7.6 0.0 4.8 5 0 0 5 5 5 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III Acetyltransf_1 PF00583.25 KOO35982.1 - 1.1e-05 25.7 0.0 2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOO35982.1 - 0.032 14.2 0.0 0.061 13.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOO35982.1 - 0.053 14.0 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOO35982.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain LRR_6 PF13516.6 KOO35983.1 - 3.2e-17 61.1 2.1 0.00086 19.2 0.0 4.7 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 KOO35983.1 - 5.6e-06 26.6 1.4 0.0016 18.8 0.0 3.1 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO35983.1 - 0.0061 16.9 1.7 55 4.9 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO35983.1 - 0.11 12.3 3.4 8.5 6.2 0.3 3.8 3 1 0 3 3 3 0 Leucine rich repeat Borrelia_P83 PF05262.11 KOO35983.1 - 1.1 7.7 22.3 1.6 7.2 22.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein TFIIA PF03153.13 KOO35983.1 - 2.8 7.8 13.3 4.1 7.3 13.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF966 PF06136.13 KOO35983.1 - 6.5 6.4 12.8 9.7 5.8 12.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TM2 PF05154.16 KOO35985.1 - 4.3e-09 36.6 3.7 4.3e-09 36.6 3.7 2.2 3 0 0 3 3 3 1 TM2 domain DEAD PF00270.29 KOO35986.1 - 1.8e-42 145.1 0.0 2.7e-42 144.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO35986.1 - 3.4e-28 98.2 0.0 2.3e-27 95.5 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KOO35986.1 - 0.052 12.8 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DFP PF04127.15 KOO35986.1 - 0.34 10.7 3.5 5 6.9 0.0 2.6 3 0 0 3 3 3 0 DNA / pantothenate metabolism flavoprotein LETM1 PF07766.13 KOO35987.1 - 1.1e-14 54.4 1.6 1.7e-14 53.8 0.1 1.9 2 0 0 2 2 2 1 LETM1-like protein MatP_C PF17414.2 KOO35987.1 - 1 9.6 4.5 17 5.7 0.2 3.1 3 0 0 3 3 3 0 MatP C-terminal ribbon-helix-helix domain DDHD PF02862.17 KOO35989.1 - 1.6e-29 103.7 0.4 4.4e-29 102.2 0.4 1.7 1 1 0 1 1 1 1 DDHD domain Hydrolase_4 PF12146.8 KOO35989.1 - 5.1e-05 22.6 0.0 0.0041 16.4 0.0 2.7 2 0 0 2 2 2 2 Serine aminopeptidase, S33 MOR2-PAG1_mid PF14228.6 KOO35989.1 - 0.11 10.1 0.6 0.16 9.6 0.6 1.1 1 0 0 1 1 1 0 Cell morphogenesis central region Anoctamin PF04547.12 KOO35990.1 - 8.9e-59 199.5 0.0 1.6e-58 198.7 0.0 1.4 1 0 0 1 1 1 1 Calcium-activated chloride channel Choline_transpo PF04515.12 KOO35990.1 - 6.3e-15 55.2 12.2 6.3e-15 55.2 12.2 5.0 4 1 0 4 4 4 1 Plasma-membrane choline transporter Ank_5 PF13857.6 KOO35990.1 - 1.5e-14 53.9 0.1 2.9e-06 27.4 0.0 3.7 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO35990.1 - 1.2e-13 51.5 0.0 7.1e-08 32.9 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO35990.1 - 3.5e-12 46.2 0.0 0.00012 22.3 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 KOO35990.1 - 1.2e-11 44.9 0.0 1e-06 29.1 0.0 3.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO35990.1 - 1.1e-07 31.6 0.0 0.00071 19.8 0.0 4.2 3 0 0 3 3 3 1 Ankyrin repeat BP28CT PF08146.12 KOO35990.1 - 0.036 13.9 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 BP28CT (NUC211) domain Methyltransf_23 PF13489.6 KOO35991.1 - 0.0043 16.9 0.0 0.0054 16.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 KOO35991.1 - 0.044 13.5 0.0 0.065 13.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Ank_2 PF12796.7 KOO35992.1 - 8.7e-100 327.5 44.4 4.6e-14 52.8 0.8 8.5 1 1 9 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO35992.1 - 1.1e-61 204.5 18.8 1.5e-08 35.0 0.1 11.0 5 3 6 11 11 11 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO35992.1 - 1.1e-47 159.5 34.2 3.6e-08 33.5 0.6 12.1 1 1 13 14 14 14 14 Ankyrin repeats (many copies) Ank PF00023.30 KOO35992.1 - 5.4e-44 146.8 53.0 0.022 15.2 0.1 14.6 13 1 1 14 14 14 14 Ankyrin repeat Ank_3 PF13606.6 KOO35992.1 - 4.8e-35 115.6 19.0 0.035 14.6 0.0 14.5 14 0 0 14 14 14 12 Ankyrin repeat SR1P PF13790.6 KOO35992.1 - 0.00014 21.9 14.8 20 5.4 0.0 9.7 12 0 0 12 12 12 1 SR1 protein SpoIIIAH PF12685.7 KOO35992.1 - 0.39 10.5 10.0 0.74 9.6 10.0 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein Phospholip_A2_2 PF05826.12 KOO35992.1 - 5.3 7.3 11.2 4.2 7.6 0.2 4.4 3 1 2 5 5 5 0 Phospholipase A2 PARP PF00644.20 KOO35993.1 - 2.2e-09 37.2 0.0 2.7e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain MOZ_SAS PF01853.18 KOO35996.1 - 1.8e-19 70.1 0.0 2.4e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 MOZ/SAS family IF2_N PF04760.15 KOO35996.1 - 0.18 11.7 0.1 0.28 11.1 0.1 1.2 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Dimer_Tnp_hAT PF05699.14 KOO35997.1 - 0.00065 19.4 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Arm PF00514.23 KOO35999.1 - 9e-43 143.1 51.1 0.00028 20.8 0.0 14.1 14 0 0 14 14 14 13 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KOO35999.1 - 1.3e-13 51.3 0.0 0.28 11.2 0.0 6.7 1 1 8 9 9 9 5 non-SMC mitotic condensation complex subunit 1 TRL PF13146.6 KOO35999.1 - 0.031 14.5 41.3 0.59 10.4 0.2 9.2 5 1 5 10 10 10 0 TRL-like protein family Clathrin PF00637.20 KOO36000.1 - 3.1e-12 46.6 0.0 1.1e-11 44.8 0.0 1.9 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_1 PF10366.9 KOO36000.1 - 0.11 12.8 0.1 14 6.1 0.0 2.4 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 TPR_12 PF13424.6 KOO36000.1 - 3.7 7.9 7.9 1.9 8.8 0.5 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 KOO36001.1 - 0.0071 17.2 1.0 0.04 14.8 0.2 2.7 2 1 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO36001.1 - 0.086 13.2 0.0 1.1 9.6 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Glyco_tran_WbsX PF14307.6 KOO36002.1 - 0.011 15.2 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase WbsX Glyco_hydro_71 PF03659.14 KOO36002.1 - 0.016 14.0 0.0 0.016 14.0 0.0 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 71 DUF2396 PF09654.10 KOO36003.1 - 0.00052 20.2 12.4 0.3 11.2 0.4 3.8 4 0 0 4 4 4 3 Protein of unknown function (DUF2396) DUF1194 PF06707.11 KOO36003.1 - 0.005 16.1 0.0 29 3.8 0.0 5.0 5 0 0 5 5 5 0 Protein of unknown function (DUF1194) ACP_PD PF04336.12 KOO36003.1 - 0.009 16.4 4.7 4.5 7.8 0.1 4.0 4 0 0 4 4 4 2 Acyl carrier protein phosphodiesterase Flg_hook PF02120.16 KOO36003.1 - 0.019 14.8 0.2 37 4.3 0.0 5.5 7 1 1 8 8 8 0 Flagellar hook-length control protein FliK GP120 PF00516.18 KOO36003.1 - 0.032 12.8 0.4 17 3.9 0.0 3.0 3 0 0 3 3 3 0 Envelope glycoprotein GP120 Arg_decarbox_C PF17944.1 KOO36003.1 - 0.082 13.5 19.1 85 3.8 0.1 8.0 8 0 0 8 8 8 0 Arginine decarboxylase C-terminal helical extension HemS PF05171.12 KOO36003.1 - 0.11 12.4 0.4 55 3.7 0.0 3.5 3 0 0 3 3 3 0 Haemin-degrading HemS.ChuX domain SelB-wing_2 PF09106.11 KOO36003.1 - 0.23 11.7 7.8 13 6.1 0.1 4.9 5 0 0 5 5 5 0 Elongation factor SelB, winged helix Beta_helix PF13229.6 KOO36004.1 - 2.7e-06 27.3 8.8 3.8e-06 26.8 8.8 1.1 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 KOO36004.1 - 0.011 15.0 3.3 0.015 14.6 3.3 1.1 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) PATR PF12951.7 KOO36004.1 - 2.1 8.5 15.4 4.4 7.5 0.1 3.0 2 1 1 3 3 3 0 Passenger-associated-transport-repeat Mannosyl_trans3 PF11051.8 KOO36006.1 - 1.4e-06 27.9 0.0 2.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.20 KOO36006.1 - 0.019 14.5 0.0 0.093 12.3 0.0 1.9 1 1 0 1 1 1 0 Glycosyl transferase family 8 DUF4455 PF14643.6 KOO36008.1 - 4.5e-78 263.0 37.3 4.5e-78 263.0 37.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4455) DUF4456 PF14644.6 KOO36008.1 - 1.9e-24 86.5 0.2 1.9e-24 86.5 0.2 6.1 4 1 1 6 6 6 1 Domain of unknown function (DUF4456) DUF5098 PF17023.5 KOO36008.1 - 0.1 11.5 1.4 0.26 10.2 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5098) zf-RING_5 PF14634.6 KOO36009.1 - 0.00025 20.9 1.3 0.00046 20.1 1.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOO36009.1 - 0.004 17.0 7.9 0.035 14.0 7.9 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Nudix_N_2 PF14803.6 KOO36009.1 - 0.029 14.3 1.7 0.084 12.8 1.7 1.8 1 0 0 1 1 1 0 Nudix N-terminal zf-RING_2 PF13639.6 KOO36009.1 - 0.031 14.6 7.6 0.16 12.3 7.6 2.1 1 1 0 1 1 1 0 Ring finger domain DUF393 PF04134.12 KOO36009.1 - 0.05 14.9 1.5 0.11 13.8 1.5 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF393 zf-RING_4 PF14570.6 KOO36009.1 - 0.35 10.7 6.4 1.3 8.9 2.6 3.0 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain DZR PF12773.7 KOO36009.1 - 0.45 10.6 3.9 15 5.7 4.4 2.3 1 1 1 2 2 2 0 Double zinc ribbon RCC1 PF00415.18 KOO36010.1 - 3.3e-51 171.7 19.0 8.3e-12 45.5 0.2 8.8 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO36010.1 - 1.9e-29 100.8 28.4 1.8e-05 24.4 0.1 6.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Arf PF00025.21 KOO36011.1 - 7.1e-77 256.8 0.0 8.4e-77 256.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOO36011.1 - 9.3e-15 54.9 0.1 1.2e-14 54.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KOO36011.1 - 2.6e-13 49.9 0.2 7.5e-09 35.2 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 KOO36011.1 - 8.1e-12 44.9 0.0 9.8e-12 44.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KOO36011.1 - 3e-11 43.2 0.0 3.5e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KOO36011.1 - 4.7e-10 39.2 0.0 5.7e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO36011.1 - 2.8e-06 27.4 0.0 4.8e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOO36011.1 - 0.0056 16.2 0.1 0.088 12.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOO36011.1 - 0.01 15.4 1.0 0.043 13.3 1.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B MeaB PF03308.16 KOO36011.1 - 0.014 14.4 0.2 0.36 9.8 0.0 2.6 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NOG1 PF06858.14 KOO36011.1 - 0.061 13.1 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Dimer_Tnp_hAT PF05699.14 KOO36012.1 - 2.4e-15 56.1 0.1 2.9e-14 52.6 0.0 2.2 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF999 PF06198.11 KOO36014.1 - 0.0087 16.1 0.3 0.0095 15.9 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF999) Pkinase PF00069.25 KOO36018.1 - 1.4e-71 241.0 0.0 4.2e-69 232.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO36018.1 - 2.2e-38 132.0 0.0 3.5e-37 128.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO36018.1 - 9.1e-05 21.9 0.0 0.00015 21.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO36018.1 - 0.003 16.9 0.0 0.0083 15.5 0.0 1.6 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO36018.1 - 0.016 14.0 0.0 0.026 13.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 KOO36018.1 - 0.032 14.1 0.0 1.2 9.1 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Glyco_trans_1_3 PF13528.6 KOO36019.1 - 0.025 13.8 0.0 0.048 12.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 1 UvrC_HhH_N PF08459.11 KOO36019.1 - 0.21 11.5 0.0 0.38 10.6 0.0 1.4 1 0 0 1 1 1 0 UvrC Helix-hairpin-helix N-terminal MerR_1 PF13411.6 KOO36019.1 - 1.4 9.0 3.8 0.8 9.8 0.5 2.3 3 0 0 3 3 3 0 MerR HTH family regulatory protein Methyltransf_21 PF05050.12 KOO36020.1 - 0.048 13.7 0.0 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase FkbM domain Gcd10p PF04189.13 KOO36021.1 - 1.6e-26 93.2 0.0 2.2e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family DUF3169 PF11368.8 KOO36023.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) AAA_13 PF13166.6 KOO36024.1 - 0.016 13.9 18.0 0.021 13.5 18.0 1.2 1 0 0 1 1 1 0 AAA domain DUF3450 PF11932.8 KOO36024.1 - 0.03 13.6 33.8 0.31 10.3 13.0 3.1 1 1 1 3 3 3 0 Protein of unknown function (DUF3450) Vps54_N PF10475.9 KOO36024.1 - 0.039 13.2 7.9 0.42 9.9 0.9 2.2 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex DUF2130 PF09903.9 KOO36024.1 - 0.048 12.9 4.4 1.5 8.0 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) FlaC_arch PF05377.11 KOO36024.1 - 0.11 12.9 6.0 1.2 9.5 0.1 3.6 4 0 0 4 4 3 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 KOO36024.1 - 0.16 12.6 0.5 0.16 12.6 0.5 5.3 1 1 5 6 6 5 0 SlyX GAS PF13851.6 KOO36024.1 - 0.27 10.5 24.1 0.11 11.9 7.7 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding NPV_P10 PF05531.12 KOO36024.1 - 0.53 10.8 4.4 8.1 7.0 0.3 3.2 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Seryl_tRNA_N PF02403.22 KOO36024.1 - 0.73 10.1 24.2 0.76 10.0 7.8 3.2 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ApoO PF09769.9 KOO36024.1 - 2.4 8.1 6.6 3.5 7.6 0.4 3.0 2 1 0 2 2 2 0 Apolipoprotein O DUF2408 PF10303.9 KOO36024.1 - 3.8 8.1 13.6 1.2e+03 -0.0 13.6 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) TMF_TATA_bd PF12325.8 KOO36024.1 - 8.4 6.6 29.2 0.82 9.9 6.0 4.0 1 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding Pkinase PF00069.25 KOO36025.1 - 5.7e-37 127.5 0.3 4.6e-34 118.0 0.1 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOO36025.1 - 1.2e-26 93.5 0.0 1.6e-26 93.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOO36025.1 - 0.00084 18.7 0.0 0.002 17.5 0.0 1.6 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOO36025.1 - 0.002 17.5 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KOO36025.1 - 0.036 13.7 0.1 0.057 13.0 0.1 1.5 1 1 0 1 1 1 0 RIO1 family ABC1 PF03109.16 KOO36025.1 - 0.047 13.8 0.1 0.69 10.1 0.0 2.0 2 0 0 2 2 2 0 ABC1 family APH PF01636.23 KOO36025.1 - 0.093 12.6 0.0 0.15 12.0 0.0 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO36025.1 - 0.13 11.0 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase UPF0016 PF01169.19 KOO36026.1 - 1.8e-19 69.8 18.4 5.3e-13 49.1 6.0 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Ost5 PF05251.12 KOO36026.1 - 0.3 11.4 6.9 0.15 12.3 2.5 2.7 3 0 0 3 3 3 0 Oligosaccharyltransferase subunit 5 DUF4131 PF13567.6 KOO36026.1 - 0.37 10.4 4.8 8.8 5.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Chor_lyase PF04345.13 KOO36027.1 - 0.2 11.3 0.1 0.34 10.5 0.1 1.3 1 0 0 1 1 1 0 Chorismate lyase STAS_2 PF13466.6 KOO36028.1 - 1 9.8 8.1 2.8 8.3 5.0 2.8 1 1 1 3 3 3 0 STAS domain Leo1 PF04004.13 KOO36028.1 - 2.5 7.9 7.3 17 5.2 4.3 2.1 1 1 1 2 2 2 0 Leo1-like protein AstE_AspA PF04952.14 KOO36029.1 - 1.5e-06 27.5 0.0 2.1e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Rep_fac-A_C PF08646.10 KOO36030.1 - 6.8e-38 129.7 0.0 6.8e-37 126.4 0.0 2.2 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 KOO36030.1 - 1.3e-26 92.4 0.9 6.6e-26 90.1 0.1 2.5 3 0 0 3 3 3 1 Replication protein A OB domain Rep-A_N PF04057.12 KOO36030.1 - 9.5e-15 54.5 0.1 2e-14 53.4 0.1 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 KOO36030.1 - 9e-13 48.0 0.1 1.5e-08 34.5 0.0 3.3 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 KOO36030.1 - 9.2e-08 32.1 0.0 0.0014 18.4 0.0 3.5 4 0 0 4 4 4 2 Cell division control protein 24, OB domain 3 TF_Zn_Ribbon PF08271.12 KOO36030.1 - 0.81 9.3 2.7 1.7 8.2 2.7 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding PhoD PF09423.10 KOO36031.1 - 1.8e-50 171.9 0.1 3.3e-50 171.1 0.1 1.4 1 0 0 1 1 1 1 PhoD-like phosphatase Rhomboid PF01694.22 KOO36031.1 - 9.5e-18 64.6 14.6 2e-17 63.6 14.6 1.6 1 0 0 1 1 1 1 Rhomboid family PhoD_N PF16655.5 KOO36031.1 - 4.3e-15 56.0 0.1 1.1e-14 54.7 0.1 1.8 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Tubulin PF00091.25 KOO36032.1 - 2.6e-37 129.0 0.0 3.4e-37 128.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain LRR_6 PF13516.6 KOO36033.1 - 4.2e-42 138.6 54.8 0.00037 20.3 0.4 22.2 22 0 0 22 22 22 10 Leucine Rich repeat Peptidase_M16_M PF16187.5 KOO36033.1 - 4.7e-36 124.5 0.0 8.3e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 KOO36033.1 - 6.6e-32 110.6 0.1 1.5e-31 109.3 0.1 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOO36033.1 - 1.8e-23 83.5 0.0 3.4e-18 66.3 0.0 2.4 2 0 0 2 2 2 2 Peptidase M16 inactive domain SpoVS PF04232.12 KOO36033.1 - 2.6e-08 33.4 0.0 1.4e-07 31.1 0.0 2.3 1 0 0 1 1 1 1 Stage V sporulation protein S (SpoVS) LRR_1 PF00560.33 KOO36033.1 - 1.9e-06 27.6 4.4 97 4.1 0.2 10.5 12 0 0 12 12 12 0 Leucine Rich Repeat LRR_4 PF12799.7 KOO36033.1 - 0.00033 21.0 19.3 6.6 7.3 0.0 10.2 12 1 0 12 12 12 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO36033.1 - 0.031 14.0 14.5 75 3.2 0.0 9.5 13 0 0 13 13 13 0 Leucine rich repeat YusW PF14039.6 KOO36033.1 - 0.084 13.4 1.3 54 4.4 0.2 5.2 5 1 0 5 5 5 0 YusW-like protein AA_kinase PF00696.28 KOO36035.1 - 6.1e-29 101.3 0.4 6.9e-29 101.1 0.4 1.0 1 0 0 1 1 1 1 Amino acid kinase family Acyl-CoA_dh_M PF02770.19 KOO36036.1 - 2.2e-21 75.8 0.1 5.9e-21 74.5 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 KOO36036.1 - 3.8e-21 75.8 1.7 1.3e-19 70.8 0.7 2.9 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_C PF12806.7 KOO36036.1 - 5.7e-15 55.6 0.2 9.8e-15 54.8 0.2 1.4 1 0 0 1 1 1 1 Acetyl-CoA dehydrogenase C-terminal like Acyl-CoA_dh_2 PF08028.11 KOO36036.1 - 0.00065 20.0 0.1 0.0016 18.7 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Aldedh PF00171.22 KOO36037.1 - 1.1e-14 53.8 5.0 7.3e-05 21.4 0.1 3.1 3 0 0 3 3 3 3 Aldehyde dehydrogenase family IQ PF00612.27 KOO36038.1 - 0.0031 17.1 17.2 0.016 15.0 1.1 3.3 3 0 0 3 3 3 3 IQ calmodulin-binding motif DUF2218 PF09981.9 KOO36038.1 - 0.0074 16.7 1.3 0.0074 16.7 1.3 2.1 1 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2218) SbmA_BacA PF05992.12 KOO36039.1 - 4.1e-64 217.0 0.7 5.5e-64 216.6 0.7 1.1 1 0 0 1 1 1 1 SbmA/BacA-like family Ank_2 PF12796.7 KOO36039.1 - 5.8e-20 71.7 0.7 2.5e-11 44.0 0.2 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO36039.1 - 6.1e-19 68.1 1.6 5.3e-08 33.3 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO36039.1 - 6.9e-18 62.9 4.4 0.0074 16.7 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KOO36039.1 - 5.1e-15 55.3 6.0 0.00012 22.3 0.2 4.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) ABC_membrane_2 PF06472.15 KOO36039.1 - 6.8e-15 55.2 0.1 1.3e-14 54.3 0.1 1.5 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 Ank PF00023.30 KOO36039.1 - 7.4e-15 54.6 7.7 0.0016 18.8 0.1 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ric8 PF10165.9 KOO36039.1 - 0.057 12.5 0.0 0.075 12.1 0.0 1.1 1 0 0 1 1 1 0 Guanine nucleotide exchange factor synembryn Abhydrolase_3 PF07859.13 KOO36040.1 - 8.9e-19 68.2 0.0 1.6e-18 67.4 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 KOO36040.1 - 2.7e-12 46.3 0.1 3e-11 42.9 0.1 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 KOO36040.1 - 2e-05 25.3 3.1 2e-05 25.3 3.1 1.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO36040.1 - 0.00018 21.2 0.1 0.00023 20.9 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 KOO36040.1 - 0.011 15.4 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Lipase PF00151.19 KOO36040.1 - 0.039 13.3 0.0 0.055 12.8 0.0 1.1 1 0 0 1 1 1 0 Lipase DUF4106 PF13388.6 KOO36044.1 - 0.12 11.6 0.1 0.18 11.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) APG6_N PF17675.1 KOO36044.1 - 6.1 7.4 21.4 0.53 10.8 8.0 3.0 3 0 0 3 3 3 0 Apg6 coiled-coil region DUF1664 PF07889.12 KOO36044.1 - 7 6.7 7.1 10 6.1 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF802 PF05650.11 KOO36044.1 - 7.4 7.1 10.9 0.48 10.9 2.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF802) Baculo_PEP_C PF04513.12 KOO36044.1 - 9.7 6.2 7.3 10 6.1 0.4 3.2 1 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus WD40 PF00400.32 KOO36047.1 - 1.7e-16 60.3 1.1 0.0024 18.6 0.0 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO36047.1 - 0.035 14.4 0.0 7.3 7.0 0.0 3.9 5 0 0 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO36047.1 - 0.16 10.9 0.1 0.82 8.6 0.0 2.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Enkurin PF13864.6 KOO36048.1 - 2.1e-25 89.0 1.6 3.3e-25 88.4 1.6 1.3 1 0 0 1 1 1 1 Calmodulin-binding AIM5 PF17050.5 KOO36048.1 - 1.1 10.2 3.8 0.84 10.5 0.8 2.3 2 1 0 2 2 2 0 Altered inheritance of mitochondria 5 Methyltr_RsmB-F PF01189.17 KOO36050.1 - 1.7e-19 70.3 0.0 2.5e-18 66.5 0.0 2.1 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F EF-hand_7 PF13499.6 KOO36052.1 - 1.3e-05 25.6 0.0 3.1e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO36052.1 - 0.0015 18.3 0.0 0.01 15.7 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO36052.1 - 0.0038 16.7 0.0 0.17 11.5 0.0 2.5 2 0 0 2 2 2 1 EF hand EccE PF11203.8 KOO36052.1 - 3.4 8.1 5.3 13 6.2 0.4 3.1 2 1 0 3 3 3 0 Putative type VII ESX secretion system translocon, EccE Csd3_N PF18059.1 KOO36053.1 - 0.0044 17.5 8.2 29 5.3 0.0 7.6 2 1 6 10 10 10 1 Csd3 N-terminal CortBP2 PF09727.9 KOO36053.1 - 0.1 12.5 86.8 1.3 8.9 9.1 7.5 2 1 7 9 9 9 0 Cortactin-binding protein-2 Response_reg PF00072.24 KOO36053.1 - 0.11 12.7 0.0 0.11 12.7 0.0 3.1 4 0 0 4 4 4 0 Response regulator receiver domain APG6_N PF17675.1 KOO36053.1 - 0.24 11.9 96.0 1.8 9.1 8.6 8.8 2 1 6 8 8 8 0 Apg6 coiled-coil region PG_binding_1 PF01471.18 KOO36054.1 - 2.6e-13 50.0 0.1 1.4e-06 28.4 0.1 2.5 2 0 0 2 2 2 2 Putative peptidoglycan binding domain Glyco_hydro_25 PF01183.20 KOO36054.1 - 7.1e-06 26.3 0.0 1.1e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 VIGSSK PF14773.6 KOO36054.1 - 0.16 12.1 0.2 0.34 11.1 0.2 1.4 1 0 0 1 1 1 0 Helicase-associated putative binding domain, C-terminal ER PF01133.17 KOO36055.1 - 1e-26 92.8 0.0 1.3e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Enhancer of rudimentary TcpF PF06340.11 KOO36055.1 - 0.022 13.7 0.0 0.027 13.4 0.0 1.1 1 0 0 1 1 1 0 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F UAA PF08449.11 KOO36056.1 - 0.032 13.4 1.3 0.17 11.0 1.0 1.9 1 1 0 1 1 1 0 UAA transporter family 2-Hacid_dh_C PF02826.19 KOO36057.1 - 1e-50 171.6 0.0 2.7e-50 170.2 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Arm PF00514.23 KOO36057.1 - 4.3e-27 93.3 21.2 2.2e-07 30.7 0.5 5.3 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 KOO36057.1 - 0.00056 19.5 1.2 0.51 9.8 0.2 2.3 1 1 1 2 2 2 2 Armadillo-like Atx10homo_assoc PF09759.9 KOO36057.1 - 0.0013 18.8 4.8 0.75 9.9 0.6 3.3 1 1 2 3 3 3 2 Spinocerebellar ataxia type 10 protein domain NAD_Gly3P_dh_N PF01210.23 KOO36057.1 - 0.0028 17.7 1.5 0.5 10.3 1.5 2.5 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 KOO36057.1 - 0.0031 17.7 1.0 0.007 16.5 0.2 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase HEAT_EZ PF13513.6 KOO36057.1 - 0.0033 17.9 14.8 0.12 12.9 0.5 3.9 1 1 3 4 4 4 3 HEAT-like repeat 2-Hacid_dh PF00389.30 KOO36057.1 - 0.024 14.3 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain EF-hand_1 PF00036.32 KOO36058.1 - 8.2e-11 40.7 1.5 0.0001 21.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO36058.1 - 8.1e-10 38.4 1.9 5.7e-05 22.9 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO36058.1 - 3.7e-09 35.8 0.3 0.00031 20.4 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO36058.1 - 6.9e-09 36.0 6.6 1.1e-06 29.0 1.7 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO36058.1 - 5.8e-06 25.6 1.5 0.0037 16.7 0.3 2.5 2 0 0 2 2 2 2 EF hand p25-alpha PF05517.12 KOO36058.1 - 0.0019 18.4 0.1 0.0025 18.0 0.1 1.2 1 0 0 1 1 1 1 p25-alpha DnaJ PF00226.31 KOO36059.1 - 0.00039 20.5 0.0 0.00042 20.4 0.0 1.1 1 0 0 1 1 1 1 DnaJ domain EcsC PF12787.7 KOO36060.1 - 0.057 13.1 0.2 0.069 12.8 0.2 1.0 1 0 0 1 1 1 0 EcsC protein family Peptidase_S46 PF10459.9 KOO36060.1 - 0.063 11.9 0.4 0.068 11.8 0.4 1.0 1 0 0 1 1 1 0 Peptidase S46 Vpu PF00558.19 KOO36060.1 - 7 6.5 8.5 11 5.9 0.6 2.3 1 1 1 2 2 2 0 Vpu protein Filamin PF00630.19 KOO36061.1 - 5.8e-09 36.7 0.0 0.0055 17.5 0.0 2.4 2 0 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO36061.1 - 0.0015 18.8 0.0 0.12 12.7 0.0 2.3 2 0 0 2 2 2 2 Invasin, domain 3 RCC1 PF00415.18 KOO36062.1 - 2.3e-17 63.3 20.1 0.00016 22.2 0.6 5.0 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO36062.1 - 3.8e-14 52.0 25.5 0.0004 20.1 0.6 5.2 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat DUF5351 PF17302.2 KOO36062.1 - 2.6 8.3 14.8 5 7.4 0.3 4.8 5 0 0 5 5 5 0 Family of unknown function (DUF5351) ABC2_membrane_3 PF12698.7 KOO36063.1 - 4e-55 187.3 48.1 4.4e-37 128.0 10.6 3.2 2 2 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 KOO36063.1 - 7.5e-53 178.7 0.2 3.1e-25 89.3 0.1 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO36063.1 - 3.8e-16 59.8 5.6 5.5e-10 39.5 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Surp PF01805.20 KOO36063.1 - 5.1e-16 58.4 0.1 1.1e-15 57.4 0.1 1.6 1 0 0 1 1 1 1 Surp module ABC2_membrane PF01061.24 KOO36063.1 - 1.3e-05 24.8 12.8 1.3e-05 24.8 12.8 3.5 2 1 0 3 3 3 1 ABC-2 type transporter AAA_29 PF13555.6 KOO36063.1 - 0.00026 20.6 4.4 0.079 12.7 0.6 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SbcCD_C PF13558.6 KOO36063.1 - 0.00051 20.2 1.0 0.35 11.1 0.0 4.1 3 2 0 3 3 2 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 KOO36063.1 - 0.00079 20.0 0.1 0.87 10.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 KOO36063.1 - 0.0037 16.7 0.1 0.69 9.3 0.0 3.0 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain Mg_chelatase PF01078.21 KOO36063.1 - 0.012 15.1 0.4 0.52 9.7 0.2 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 KOO36063.1 - 0.025 14.5 0.5 3.5 7.5 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase MukB PF04310.12 KOO36063.1 - 0.028 14.2 4.2 0.53 10.1 0.4 2.4 2 0 0 2 2 2 0 MukB N-terminal ABC2_membrane_2 PF12679.7 KOO36063.1 - 0.056 12.7 34.6 0.26 10.5 8.8 2.8 2 1 0 2 2 2 0 ABC-2 family transporter protein Cas_Csa4 PF09703.10 KOO36063.1 - 0.074 12.4 0.2 7 5.9 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csa4) AAA_30 PF13604.6 KOO36063.1 - 0.26 11.0 1.7 1.7 8.4 0.1 2.6 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.22 KOO36063.1 - 0.4 10.3 4.7 2.6 7.6 0.6 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain FAD_binding_3 PF01494.19 KOO36065.1 - 1.3e-13 50.9 10.7 3.6e-06 26.5 1.5 3.1 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 KOO36065.1 - 4.9e-06 26.7 0.3 1.9e-05 24.8 0.3 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOO36065.1 - 0.00024 20.3 0.5 0.00024 20.3 0.5 2.0 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 KOO36065.1 - 0.00046 19.9 0.2 0.00046 19.9 0.2 2.1 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOO36065.1 - 0.0027 17.0 0.4 0.012 14.9 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO36065.1 - 0.012 14.9 0.2 0.018 14.3 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOO36065.1 - 0.15 10.9 0.4 1.6 7.5 0.1 2.0 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 KOO36065.1 - 0.17 10.5 0.2 0.24 10.0 0.2 1.1 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 KOO36065.1 - 0.19 12.3 0.3 0.97 10.0 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Nucleotid_trans PF03407.16 KOO36066.1 - 3.2e-32 112.2 0.0 4.5e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF4127 PF13552.6 KOO36066.1 - 0.15 10.7 0.0 0.21 10.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) LRR_5 PF13306.6 KOO36067.1 - 7.5e-73 242.5 0.0 4e-39 133.5 0.0 2.2 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO36067.1 - 1.9e-12 46.7 0.0 0.011 15.5 0.0 5.4 2 1 3 5 5 5 4 Leucine rich repeat He_PIG PF05345.12 KOO36067.1 - 2.7 8.2 9.2 42 4.4 0.1 5.9 8 0 0 8 8 8 0 Putative Ig domain EB1 PF03271.17 KOO36068.1 - 8.4e-16 57.9 2.0 1.8e-15 56.9 2.0 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 KOO36068.1 - 5.5e-09 36.2 0.1 1.8e-08 34.6 0.1 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 KOO36068.1 - 0.0023 18.0 0.1 0.0063 16.6 0.1 1.8 1 0 0 1 1 1 1 CH-like domain in sperm protein SAM_2 PF07647.17 KOO36068.1 - 0.17 12.0 0.1 9.7 6.4 0.0 2.4 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF2475 PF10629.9 KOO36069.1 - 0.0034 17.6 0.1 0.0095 16.1 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2475) DnaJ_C PF01556.18 KOO36070.1 - 1.5e-36 125.7 0.1 1.7e-36 125.5 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain PolC_DP2 PF03833.13 KOO36070.1 - 0.096 10.5 1.8 0.12 10.3 1.8 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Mitoc_L55 PF09776.9 KOO36071.1 - 0.0012 18.5 0.1 30 4.4 0.0 4.0 1 1 3 4 4 4 3 Mitochondrial ribosomal protein L55 tRNA_int_endo PF01974.17 KOO36071.1 - 0.083 13.0 0.0 12 6.1 0.0 2.1 2 0 0 2 2 2 0 tRNA intron endonuclease, catalytic C-terminal domain Pr_beta_C PF12465.8 KOO36073.1 - 0.11 11.9 0.1 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 Proteasome beta subunits C terminal SET PF00856.28 KOO36075.1 - 0.0002 21.8 0.0 0.0003 21.2 0.0 1.2 1 0 0 1 1 1 1 SET domain Attachment_P66 PF11263.8 KOO36075.1 - 0.069 12.4 0.2 0.1 11.8 0.2 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi attachment protein P66 ERG4_ERG24 PF01222.17 KOO36076.1 - 1.9e-64 218.0 10.6 2.5e-64 217.6 10.6 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 KOO36076.1 - 7.5e-06 25.6 0.3 7.5e-06 25.6 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) RVT_1 PF00078.27 KOO36077.1 - 0.12 11.9 0.0 0.29 10.6 0.0 1.6 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5536 PF17688.1 KOO36078.1 - 0.002 18.0 2.6 0.82 9.5 0.1 3.2 2 0 0 2 2 2 2 Family of unknown function (DUF5536) HTH_32 PF13565.6 KOO36078.1 - 0.7 10.5 12.2 0.55 10.9 0.8 4.9 3 3 0 3 3 3 0 Homeodomain-like domain LRR_6 PF13516.6 KOO36079.1 - 5.3e-12 44.8 0.7 0.062 13.4 0.1 5.8 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 KOO36079.1 - 0.0032 17.9 0.0 8.1 7.0 0.0 3.4 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO36079.1 - 0.014 15.1 1.6 11 5.8 0.1 4.0 3 2 0 3 3 3 0 Leucine rich repeat AAA_12 PF13087.6 KOO36080.1 - 6.1e-49 166.4 0.0 1.3e-48 165.2 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KOO36080.1 - 7.6e-41 140.6 0.4 4.7e-23 82.3 0.5 2.1 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 KOO36080.1 - 1e-13 51.4 0.6 3.4e-13 49.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOO36080.1 - 3.5e-09 37.1 0.1 1.2e-08 35.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOO36080.1 - 7.7e-07 29.1 0.0 0.015 15.1 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 KOO36080.1 - 4.2e-05 24.0 0.2 0.00014 22.3 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain UvrD_C_2 PF13538.6 KOO36080.1 - 0.00026 20.8 0.1 0.0076 16.1 0.0 2.5 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain PhoH PF02562.16 KOO36080.1 - 0.0012 18.3 0.1 1 8.8 0.0 2.4 3 0 0 3 3 3 2 PhoH-like protein DUF2075 PF09848.9 KOO36080.1 - 0.0034 16.7 0.3 0.084 12.1 0.0 2.5 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 KOO36080.1 - 0.025 14.8 0.1 0.057 13.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOO36080.1 - 0.04 13.5 0.2 0.18 11.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 KOO36080.1 - 0.099 12.6 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA PF00004.29 KOO36080.1 - 0.11 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO36080.1 - 0.11 12.4 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) UvrD-helicase PF00580.21 KOO36080.1 - 0.29 10.6 0.0 2.6 7.5 0.0 1.9 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain PhrC_PhrF PF11131.8 KOO36080.1 - 0.35 10.5 1.8 23 4.7 0.1 2.5 2 0 0 2 2 2 0 Rap-phr extracellular signalling Usp PF00582.26 KOO36082.1 - 7.5e-11 42.7 5.9 6.3e-06 26.8 0.6 3.7 2 2 0 2 2 2 2 Universal stress protein family Arm PF00514.23 KOO36084.1 - 9.2e-12 44.6 0.8 2.4e-08 33.7 0.0 2.7 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOO36084.1 - 0.026 14.5 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain ART PF01129.18 KOO36085.1 - 7.2e-07 28.7 1.0 1.7e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO36085.1 - 2.2e-06 27.1 0.0 6.6e-06 25.6 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme DUF3086 PF11285.8 KOO36085.1 - 0.18 10.9 2.4 0.21 10.6 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) Apolipoprotein PF01442.18 KOO36085.1 - 0.65 9.9 0.0 0.65 9.9 0.0 3.4 3 1 0 3 3 3 0 Apolipoprotein A1/A4/E domain EF-hand_5 PF13202.6 KOO36088.1 - 8.8e-06 25.0 0.0 1.5e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO36088.1 - 6.3e-05 22.2 0.0 0.00012 21.4 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO36088.1 - 0.0038 17.1 0.0 0.0062 16.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOO36088.1 - 0.026 15.0 0.0 0.04 14.4 0.0 1.6 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 KOO36088.1 - 0.094 12.6 0.0 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain pair DUF4604 PF15377.6 KOO36088.1 - 1.5 9.2 17.5 1.8 8.9 17.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Membralin PF09746.9 KOO36088.1 - 3.6 6.5 5.4 4.3 6.3 5.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein RR_TM4-6 PF06459.12 KOO36088.1 - 3.7 7.3 14.4 4.1 7.2 14.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 KOO36088.1 - 9.5 6.2 9.6 12 5.9 9.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Gly-zipper_Omp PF13488.6 KOO36089.1 - 2.6 8.1 17.2 0.49 10.4 2.0 3.3 3 0 0 3 3 3 0 Glycine zipper 2OG-FeII_Oxy_3 PF13640.6 KOO36090.1 - 1.6e-09 38.5 0.0 1.9e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DivIVA PF05103.13 KOO36091.1 - 0.39 10.8 17.8 1.2 9.2 5.2 2.1 1 1 1 2 2 2 0 DivIVA protein ATP-synt_B PF00430.18 KOO36091.1 - 0.46 10.6 25.9 0.13 12.3 20.5 2.1 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) DUF5401 PF17380.2 KOO36091.1 - 1.1 7.3 10.3 1.3 7.0 10.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) V-ATPase_G_2 PF16999.5 KOO36091.1 - 2.2 8.7 26.4 6 7.3 7.2 2.6 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit DUF3347 PF11827.8 KOO36091.1 - 2.3 8.4 4.9 3.6 7.7 4.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3347) Rab3-GTPase_cat PF13890.6 KOO36092.1 - 7.6e-37 126.5 0.0 2.2e-36 125.0 0.0 1.7 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit Pkinase PF00069.25 KOO36092.1 - 1.3e-30 106.7 0.0 2.4e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO36092.1 - 2.2e-15 56.6 0.0 3.8e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO36092.1 - 0.015 15.3 0.0 0.015 15.3 0.0 3.4 3 1 0 4 4 4 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO36092.1 - 0.024 14.0 1.3 0.063 12.6 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyoxalase_3 PF13468.6 KOO36092.1 - 2 8.5 7.7 0.3 11.2 0.5 2.5 2 0 0 2 2 2 0 Glyoxalase-like domain LRR_6 PF13516.6 KOO36099.1 - 3.9e-53 173.0 28.6 0.0003 20.6 0.1 13.2 13 0 0 13 13 13 11 Leucine Rich repeat EIF_2_alpha PF07541.12 KOO36099.1 - 0.00036 20.6 1.1 1.9 8.6 0.2 4.0 2 1 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit LRR_4 PF12799.7 KOO36099.1 - 0.025 15.0 15.3 37 4.9 0.0 7.7 7 3 2 9 9 9 0 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.12 KOO36099.1 - 2 8.8 4.4 23 5.4 0.0 4.2 5 0 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding HOASN PF14515.6 KOO36099.1 - 4.8 7.6 30.9 19 5.8 0.5 9.0 2 2 7 9 9 9 0 Haem-oxygenase-associated N-terminal helices RSN1_7TM PF02714.15 KOO36100.1 - 7.8e-07 28.7 1.7 1.8e-06 27.5 1.0 2.0 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 KOO36100.1 - 0.0051 17.1 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter TMC PF07810.13 KOO36100.1 - 0.06 13.9 0.1 0.06 13.9 0.1 2.5 3 0 0 3 3 3 0 TMC domain Anoctamin PF04547.12 KOO36100.1 - 0.081 11.8 1.6 0.15 10.9 1.6 1.4 1 1 0 1 1 1 0 Calcium-activated chloride channel EzrA PF06160.12 KOO36120.1 - 0.00032 19.0 6.2 0.00037 18.8 6.2 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA FAM184 PF15665.5 KOO36120.1 - 0.0042 16.9 19.0 0.055 13.3 6.3 2.0 2 0 0 2 2 2 2 Family with sequence similarity 184, A and B Luteo_P1-P2 PF08467.10 KOO36120.1 - 0.0047 16.2 1.6 0.0051 16.1 1.6 1.2 1 0 0 1 1 1 1 Luteovirus RNA polymerase P1-P2/replicase DUF4201 PF13870.6 KOO36120.1 - 0.01 15.6 12.7 0.15 11.8 1.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Exonuc_VII_L PF02601.15 KOO36120.1 - 0.031 13.8 11.7 0.036 13.7 11.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CK2S PF15011.6 KOO36120.1 - 0.065 13.1 12.7 0.35 10.7 2.1 2.2 2 0 0 2 2 2 0 Casein Kinase 2 substrate DHR10 PF18595.1 KOO36120.1 - 0.089 12.9 24.1 0.27 11.3 5.6 2.3 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Med11 PF10280.9 KOO36120.1 - 0.091 13.2 5.7 0.23 11.9 5.6 1.8 1 1 0 1 1 1 0 Mediator complex protein GTP-bdg_M PF16360.5 KOO36120.1 - 0.099 13.3 6.3 0.6 10.8 0.0 3.1 3 2 0 3 3 2 0 GTP-binding GTPase Middle Region MscS_porin PF12795.7 KOO36120.1 - 0.14 11.7 21.4 1.4 8.4 20.2 2.0 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain RecG_N PF17190.4 KOO36120.1 - 0.14 12.9 4.1 1 10.1 0.9 2.3 2 0 0 2 2 2 0 RecG N-terminal helical domain Laminin_II PF06009.12 KOO36120.1 - 0.15 12.1 7.4 0.36 10.8 1.3 2.6 1 1 0 2 2 2 0 Laminin Domain II HIP1_clath_bdg PF16515.5 KOO36120.1 - 0.33 11.6 22.5 0.48 11.1 8.6 2.7 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CART PF06373.11 KOO36120.1 - 0.95 9.7 4.1 4.8 7.4 0.5 2.9 3 0 0 3 3 3 0 Cocaine and amphetamine regulated transcript protein (CART) DUF1664 PF07889.12 KOO36120.1 - 1 9.4 8.2 0.44 10.6 2.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 KOO36120.1 - 1 8.5 11.5 2.6 7.2 2.2 2.0 1 1 1 2 2 2 0 TMPIT-like protein CENP-H PF05837.12 KOO36120.1 - 1.1 9.7 16.9 0.67 10.4 3.9 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Prominin PF05478.11 KOO36120.1 - 1.1 7.1 7.4 1.9 6.4 7.4 1.4 1 1 0 1 1 1 0 Prominin DUF4407 PF14362.6 KOO36120.1 - 1.1 8.5 15.1 1.5 8.1 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PRKG1_interact PF15898.5 KOO36120.1 - 1.2 10.0 14.5 0.29 12.0 6.8 2.4 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Effector_1 PF04518.12 KOO36120.1 - 1.3 8.1 8.7 2.9 6.9 0.9 2.0 2 0 0 2 2 2 0 Effector from type III secretion system NPV_P10 PF05531.12 KOO36120.1 - 1.3 9.6 10.7 13 6.3 2.3 3.4 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Jnk-SapK_ap_N PF09744.9 KOO36120.1 - 1.8 8.8 18.0 1.5 9.0 16.4 1.7 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FUSC PF04632.12 KOO36120.1 - 4.8 5.6 19.2 1.4 7.4 8.7 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family betaPIX_CC PF16523.5 KOO36120.1 - 5 7.0 11.0 0.3 11.0 1.2 2.7 1 1 2 3 3 3 0 betaPIX coiled coil OmpH PF03938.14 KOO36120.1 - 8.3 6.7 21.4 1 9.7 11.2 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF3391 PF11871.8 KOO36120.1 - 9.6 6.7 12.4 3.8e+02 1.6 12.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) MRNIP PF15749.5 KOO36120.1 - 9.8 6.9 11.5 10 6.9 1.8 2.2 1 1 1 2 2 2 0 MRN-interacting protein Snapin_Pallidin PF14712.6 KOO36121.1 - 0.14 12.6 0.4 0.14 12.6 0.4 2.7 1 1 2 3 3 3 0 Snapin/Pallidin Calpain_inhib PF00748.19 KOO36121.1 - 0.34 11.4 4.5 0.28 11.7 3.0 1.7 1 1 1 2 2 2 0 Calpain inhibitor Myb_DNA-binding PF00249.31 KOO36123.1 - 3.9e-25 87.8 5.8 6.9e-12 45.4 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOO36123.1 - 4.3e-19 68.5 0.3 5e-12 45.9 0.3 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOO36123.1 - 2.1e-05 24.3 0.3 0.00015 21.6 0.0 2.0 1 1 1 2 2 2 1 Myb DNA-binding like SANT_DAMP1_like PF16282.5 KOO36123.1 - 0.0085 16.3 0.8 1.1 9.5 0.1 2.2 1 1 1 2 2 2 2 SANT/Myb-like domain of DAMP1 SLIDE PF09111.10 KOO36123.1 - 0.066 13.2 0.0 0.28 11.2 0.0 1.8 1 1 1 2 2 2 0 SLIDE Myb_DNA-bind_4 PF13837.6 KOO36123.1 - 0.15 12.4 1.3 7 7.1 0.3 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.25 KOO36124.1 - 5e-58 196.5 0.0 6e-58 196.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO36124.1 - 3.5e-38 131.4 0.0 4.4e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO36124.1 - 2.1e-06 27.3 0.0 4.8e-06 26.1 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOO36124.1 - 0.062 12.1 0.0 0.082 11.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 KOO36124.1 - 0.08 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOO36124.1 - 0.088 12.7 1.5 1.8 8.5 0.1 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family Ank_2 PF12796.7 KOO36125.1 - 4.4e-16 59.2 2.8 1.4e-08 35.2 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO36125.1 - 7.3e-16 58.3 6.4 2.3e-06 28.0 1.6 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO36125.1 - 9.7e-12 44.0 8.6 0.0048 17.3 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat EF-hand_1 PF00036.32 KOO36125.1 - 7.6e-11 40.8 0.3 0.00012 21.3 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO36125.1 - 4.9e-09 36.5 0.2 8.8e-09 35.7 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO36125.1 - 8.7e-09 34.6 0.1 0.0015 18.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain Ank_5 PF13857.6 KOO36125.1 - 4.9e-08 33.1 6.2 0.00016 21.9 0.3 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO36125.1 - 3.3e-05 24.1 12.0 0.023 15.1 0.1 4.4 5 0 0 5 5 5 2 Ankyrin repeat EF-hand_5 PF13202.6 KOO36125.1 - 6.6e-05 22.2 0.3 0.2 11.2 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO36125.1 - 0.00015 21.6 0.1 0.00034 20.4 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 KOO36125.1 - 0.01 16.1 0.0 0.022 15.1 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO36125.1 - 0.097 13.0 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Thioredoxin PF00085.20 KOO36126.1 - 5.9e-24 84.0 0.0 1.2e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOO36126.1 - 9.6e-05 22.8 0.0 0.0012 19.3 0.0 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 KOO36126.1 - 0.00014 21.8 0.0 0.0008 19.3 0.0 1.9 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.6 KOO36126.1 - 0.055 13.8 0.0 0.15 12.4 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like OST3_OST6 PF04756.13 KOO36126.1 - 0.22 10.8 0.8 0.26 10.6 0.0 1.4 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family cNMP_binding PF00027.29 KOO36127.1 - 1.2e-10 41.3 0.0 2.5e-05 24.2 0.0 3.0 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain Galactosyl_T PF01762.21 KOO36128.1 - 1.1e-07 31.9 0.0 2.2e-07 30.9 0.0 1.4 2 0 0 2 2 2 1 Galactosyltransferase ASH PF15780.5 KOO36129.1 - 5.5e-12 45.8 0.0 1.6e-11 44.3 0.0 1.7 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 KOO36129.1 - 0.00098 19.2 0.0 0.038 14.1 0.0 2.3 2 0 0 2 2 2 1 Flagellar-associated PapD-like DGF-1_C PF11040.8 KOO36129.1 - 0.031 14.3 2.7 0.11 12.5 2.7 2.0 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Moricin PF06451.11 KOO36130.1 - 0.13 12.1 0.2 0.3 10.9 0.2 1.6 1 0 0 1 1 1 0 Moricin Lsm_C PF14894.6 KOO36133.1 - 0.16 11.7 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Lsm C-terminal NUDE_C PF04880.13 KOO36134.1 - 0.0058 17.1 6.3 0.0058 17.1 6.3 2.1 2 1 0 2 2 2 1 NUDE protein, C-terminal conserved region Big_1 PF02369.16 KOO36134.1 - 0.018 15.0 1.4 0.031 14.3 1.4 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) DUF501 PF04417.12 KOO36134.1 - 0.078 12.8 0.3 0.13 12.0 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF501) DUF4570 PF15134.6 KOO36134.1 - 0.12 12.4 1.4 0.19 11.8 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) CCD PF07860.11 KOO36134.1 - 0.24 11.4 1.5 0.4 10.7 1.5 1.3 1 0 0 1 1 1 0 WisP family C-Terminal Region MMR_HSR1 PF01926.23 KOO36135.1 - 0.00014 21.9 0.0 0.00025 21.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GBP PF02263.19 KOO36135.1 - 0.0005 19.4 3.1 0.0073 15.6 0.1 2.1 1 1 1 2 2 2 2 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 KOO36135.1 - 0.0079 16.3 0.6 0.35 10.9 0.0 2.3 1 1 1 2 2 2 1 Dynamin family NIF PF03031.18 KOO36135.1 - 0.011 15.5 0.3 0.02 14.6 0.3 1.5 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase RFX1_trans_act PF04589.13 KOO36135.1 - 0.11 12.7 0.6 0.2 11.8 0.6 1.3 1 0 0 1 1 1 0 RFX1 transcription activation region Arf PF00025.21 KOO36135.1 - 0.16 11.4 0.3 0.29 10.6 0.0 1.5 2 0 0 2 2 2 0 ADP-ribosylation factor family Helicase_C PF00271.31 KOO36139.1 - 8.1e-10 39.0 0.0 1e-09 38.7 0.0 1.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain FtsK_4TM PF13491.6 KOO36140.1 - 0.043 13.5 3.8 0.057 13.1 3.8 1.1 1 0 0 1 1 1 0 4TM region of DNA translocase FtsK/SpoIIIE Nramp PF01566.18 KOO36140.1 - 1 8.3 7.0 0.83 8.6 5.4 1.6 1 1 1 2 2 2 0 Natural resistance-associated macrophage protein TTL PF03133.15 KOO36141.1 - 1.3e-32 113.2 0.0 1.8e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO36141.1 - 3.6e-05 23.2 0.0 0.073 12.3 0.0 2.2 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO36141.1 - 0.012 14.9 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp Dala_Dala_lig_C PF07478.13 KOO36141.1 - 0.054 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus NAD_binding_1 PF00175.21 KOO36143.1 - 1.9e-22 80.0 0.0 3.6e-22 79.1 0.0 1.5 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOO36143.1 - 1.8e-15 57.1 0.0 1.6e-14 54.0 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain Pkinase_Tyr PF07714.17 KOO36143.1 - 0.035 13.4 0.0 0.054 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase NAD_binding_6 PF08030.12 KOO36143.1 - 0.043 13.9 0.0 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 Ferric reductase NAD binding domain HTH_31 PF13560.6 KOO36144.1 - 0.31 11.4 4.5 0.13 12.6 1.8 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain EF-hand_6 PF13405.6 KOO36145.1 - 1.7e-09 36.8 0.0 2.9e-05 23.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO36145.1 - 5.6e-09 36.3 0.0 1.4e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO36145.1 - 1.8e-05 23.9 0.0 0.0018 17.7 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO36145.1 - 6.8e-05 22.2 0.0 0.031 13.8 0.0 2.8 2 0 0 2 2 2 2 EF hand DUF2407 PF10302.9 KOO36145.1 - 0.00054 20.5 0.0 0.00054 20.5 0.0 2.8 3 0 0 3 3 3 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 KOO36145.1 - 0.0034 17.1 0.0 0.01 15.6 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin family EF-hand_8 PF13833.6 KOO36145.1 - 0.0096 15.7 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair Peptidase_C26 PF07722.13 KOO36147.1 - 0.12 12.1 0.0 0.14 11.9 0.0 1.0 1 0 0 1 1 1 0 Peptidase C26 CH_2 PF06294.11 KOO36148.1 - 1.3e-31 108.6 0.0 3e-31 107.4 0.0 1.7 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 KOO36148.1 - 5.7e-11 42.1 0.0 1.4e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 CAMSAP CH domain DHQ_synthase PF01761.20 KOO36149.1 - 6.7e-94 313.9 0.0 8.7e-94 313.5 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 KOO36149.1 - 1.5e-08 34.6 1.4 2e-06 27.7 0.1 3.0 3 0 0 3 3 3 2 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 KOO36149.1 - 0.012 14.5 1.9 0.44 9.3 0.5 2.9 3 0 0 3 3 3 0 Iron-containing alcohol dehydrogenase DUF393 PF04134.12 KOO36150.1 - 0.0014 20.0 4.4 0.23 12.8 1.6 2.1 1 1 1 2 2 2 2 Protein of unknown function, DUF393 DHHC PF01529.20 KOO36151.1 - 3.4e-19 69.3 0.1 3.4e-19 69.3 0.1 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase VirB3 PF05101.13 KOO36151.1 - 2.8 8.2 8.7 7.7 6.8 0.2 2.9 2 1 1 3 3 3 0 Type IV secretory pathway, VirB3-like protein EF-hand_7 PF13499.6 KOO36152.1 - 6.2e-05 23.4 0.5 0.0036 17.7 0.2 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO36152.1 - 0.0042 16.9 0.1 0.14 12.1 0.1 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO36152.1 - 0.26 10.9 0.8 0.84 9.3 0.1 2.3 2 0 0 2 2 2 0 EF hand EF-hand_5 PF13202.6 KOO36152.1 - 0.54 9.9 3.0 0.51 9.9 0.2 2.3 2 0 0 2 2 2 0 EF hand ART PF01129.18 KOO36153.1 - 1.1e-06 28.1 0.1 4.2e-05 22.9 0.0 2.5 1 1 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO36153.1 - 3.6e-05 23.2 0.4 0.00093 18.6 0.4 2.5 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Spc24 PF08286.11 KOO36153.1 - 0.76 10.0 9.1 0.23 11.7 0.7 2.7 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Med21 PF11221.8 KOO36153.1 - 3.8 7.8 14.2 7 6.9 5.5 2.6 2 0 0 2 2 2 0 Subunit 21 of Mediator complex SlyX PF04102.12 KOO36153.1 - 8 7.2 10.8 0.61 10.7 2.0 2.7 2 0 0 2 2 2 0 SlyX Rho_Binding PF08912.11 KOO36153.1 - 8.5 7.3 16.1 10 7.0 1.1 2.9 2 0 0 2 2 2 0 Rho Binding Pkinase PF00069.25 KOO36454.1 - 3.3e-30 105.4 0.0 8.3e-30 104.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO36454.1 - 1.8e-23 83.2 0.0 2.6e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_4 PF12763.7 KOO36454.1 - 0.00046 20.1 0.0 0.00084 19.3 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand APH PF01636.23 KOO36454.1 - 0.0014 18.6 0.1 0.012 15.5 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family EF-hand_7 PF13499.6 KOO36454.1 - 0.033 14.6 0.0 0.076 13.5 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Pox_ser-thr_kin PF05445.11 KOO36454.1 - 0.095 11.7 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PDZ_6 PF17820.1 KOO36454.1 - 0.13 12.1 0.2 0.57 10.1 0.1 2.1 2 0 0 2 2 2 0 PDZ domain Kinase-like PF14531.6 KOO36454.1 - 0.19 11.0 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like VWA_3 PF13768.6 KOO36457.1 - 0.027 14.4 0.0 0.075 13.0 0.0 1.8 1 0 0 1 1 1 0 von Willebrand factor type A domain Chromo PF00385.24 KOO36458.1 - 8.6e-08 32.0 0.0 2.2e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SET PF00856.28 KOO36458.1 - 3e-05 24.5 0.0 0.0011 19.4 0.0 2.8 2 1 0 2 2 2 1 SET domain DUF3123 PF11321.8 KOO36458.1 - 0.0002 22.0 6.0 0.1 13.2 0.1 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF3123) PHD PF00628.29 KOO36458.1 - 0.00052 19.9 6.4 0.0011 18.8 6.4 1.5 1 0 0 1 1 1 1 PHD-finger Myb_DNA-binding PF00249.31 KOO36458.1 - 0.015 15.5 0.0 0.04 14.1 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain His_Phos_1 PF00300.22 KOO36458.1 - 0.019 14.6 1.0 0.11 12.1 0.0 2.3 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) ELM2 PF01448.24 KOO36458.1 - 0.023 15.4 1.0 0.08 13.7 0.0 2.4 3 0 0 3 3 3 0 ELM2 domain PHD_2 PF13831.6 KOO36458.1 - 0.27 10.8 2.9 0.52 9.9 2.9 1.5 1 0 0 1 1 1 0 PHD-finger zinc_ribbon_4 PF13717.6 KOO36458.1 - 0.39 10.7 1.5 0.57 10.2 0.0 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Agenet PF05641.12 KOO36458.1 - 1.6 9.3 12.4 9.6 6.8 0.2 4.5 5 0 0 5 5 5 0 Agenet domain Ank_2 PF12796.7 KOO36459.1 - 9.3e-34 115.9 4.2 3.1e-14 53.3 0.1 3.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO36459.1 - 3.4e-20 72.1 0.5 6.8e-08 32.9 0.1 4.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO36459.1 - 5e-19 68.1 2.1 4.2e-08 33.3 0.1 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO36459.1 - 2e-16 58.4 1.9 0.0001 22.4 0.1 5.3 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 KOO36459.1 - 8.7e-16 57.6 4.8 2.8e-05 24.3 0.1 4.3 4 0 0 4 4 4 3 Ankyrin repeat Phospholip_A2_2 PF05826.12 KOO36459.1 - 0.016 15.4 0.4 0.034 14.4 0.1 1.7 2 0 0 2 2 2 0 Phospholipase A2 zf-MIZ PF02891.20 KOO36460.1 - 0.0034 17.1 1.6 1.7 8.4 0.1 2.4 2 0 0 2 2 2 2 MIZ/SP-RING zinc finger DUF4763 PF15960.5 KOO36460.1 - 0.092 12.0 0.7 9.8 5.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) DUF2378 PF09536.10 KOO36460.1 - 0.12 12.2 0.1 0.51 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2378) YccV-like PF08755.11 KOO36461.1 - 9.7e-14 51.7 0.0 4.2e-13 49.6 0.0 1.9 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like Dor1 PF04124.12 KOO36461.1 - 0.045 12.4 0.1 0.073 11.7 0.1 1.3 1 0 0 1 1 1 0 Dor1-like family UVR PF02151.19 KOO36461.1 - 0.64 9.8 7.8 0.063 13.1 2.8 2.0 2 0 0 2 2 2 0 UvrB/uvrC motif AAA_23 PF13476.6 KOO36462.1 - 3.1e-17 63.7 4.6 3.1e-17 63.7 4.6 5.9 2 2 3 5 5 3 2 AAA domain SMC_N PF02463.19 KOO36462.1 - 1.1e-15 57.6 38.1 7.2e-15 55.0 38.1 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOO36462.1 - 8.7e-05 22.2 0.5 0.00018 21.2 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 KOO36462.1 - 9e-05 22.4 1.0 0.003 17.4 0.1 2.8 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KOO36462.1 - 0.0002 21.2 25.9 0.0002 21.2 25.9 4.5 2 2 0 2 2 1 1 AAA ATPase domain EzrA PF06160.12 KOO36462.1 - 0.00094 17.5 20.0 0.00094 17.5 20.0 5.0 2 2 1 5 5 5 4 Septation ring formation regulator, EzrA DUF3958 PF13125.6 KOO36462.1 - 0.0084 16.3 3.3 0.0084 16.3 3.3 6.8 5 1 1 6 6 6 2 Protein of unknown function (DUF3958) RsgA_GTPase PF03193.16 KOO36462.1 - 0.028 14.3 0.0 0.028 14.3 0.0 2.8 3 1 0 3 3 3 0 RsgA GTPase ABC_tran PF00005.27 KOO36462.1 - 0.15 12.6 0.1 0.15 12.6 0.1 5.7 4 2 0 4 4 2 0 ABC transporter AAA_22 PF13401.6 KOO36462.1 - 0.24 11.7 10.9 5.8 7.2 0.0 4.6 3 2 0 3 3 3 0 AAA domain CotJB PF12652.7 KOO36462.1 - 0.61 10.3 9.1 0.27 11.5 0.5 4.3 2 1 1 3 3 3 0 CotJB protein Ribosomal_60s PF00428.19 KOO36465.1 - 1.3 9.7 20.2 3.9 8.1 20.2 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein SCP2 PF02036.17 KOO36467.1 - 1.3e-21 77.0 0.3 1.5e-21 76.7 0.3 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 KOO36467.1 - 8.4e-05 22.9 0.2 0.00011 22.5 0.2 1.3 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal MDMPI_C PF07398.11 KOO36467.1 - 0.0017 19.2 0.0 0.0026 18.6 0.0 1.3 1 0 0 1 1 1 1 MDMPI C-terminal domain Na_H_Exchanger PF00999.21 KOO36468.1 - 6.7e-28 97.6 34.9 3.8e-21 75.3 19.8 2.1 1 1 1 2 2 2 2 Sodium/hydrogen exchanger family TTL PF03133.15 KOO36469.1 - 7.5e-51 173.0 0.0 1.2e-50 172.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family UQ_con PF00179.26 KOO36469.1 - 3e-19 69.0 0.0 4.8e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ATPgrasp_YheCD PF14398.6 KOO36469.1 - 5.4e-07 29.1 0.0 0.0037 16.5 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp RimK PF08443.11 KOO36469.1 - 0.036 13.6 0.0 3.3 7.3 0.0 2.2 2 0 0 2 2 2 0 RimK-like ATP-grasp domain PDZ PF00595.24 KOO36552.1 - 3e-17 62.7 0.0 0.0082 16.5 0.0 4.5 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 KOO36552.1 - 1.5e-06 28.0 8.9 2 8.3 0.1 4.9 5 0 0 5 5 5 4 PDZ domain PDZ_2 PF13180.6 KOO36552.1 - 0.00014 22.1 0.1 12 6.3 0.0 3.9 4 0 0 4 4 4 2 PDZ domain WW PF00397.26 KOO36552.1 - 0.00049 20.1 0.2 0.0011 19.0 0.2 1.6 1 0 0 1 1 1 1 WW domain ArgoL2 PF16488.5 KOO36552.1 - 0.0022 18.3 1.9 1.9 8.9 0.0 3.4 3 0 0 3 3 3 1 Argonaute linker 2 domain DUF3394 PF11874.8 KOO36552.1 - 0.036 13.8 0.0 33 4.1 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF3394) Glycos_transf_1 PF00534.20 KOO36552.1 - 0.056 13.0 0.1 13 5.2 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferases group 1 TPX2_importin PF12214.8 KOO36612.1 - 2.4e-15 57.1 3.0 2.4e-15 57.1 3.0 7.0 4 1 2 6 6 6 4 Cell cycle regulated microtubule associated protein TPX2 PF06886.11 KOO36612.1 - 6.2e-07 29.5 12.6 6.2e-07 29.5 12.6 5.4 6 0 0 6 6 6 2 Targeting protein for Xklp2 (TPX2) SLC12 PF03522.15 KOO36612.1 - 4 6.4 7.7 0.82 8.6 0.0 2.6 2 0 0 2 2 2 0 Solute carrier family 12 RPE65 PF03055.15 KOO36613.1 - 3.7e-50 171.5 0.0 1e-49 170.0 0.0 1.6 1 1 0 1 1 1 1 Retinal pigment epithelial membrane protein Cyt-b5 PF00173.28 KOO36613.1 - 1.3e-20 73.3 0.1 2.3e-20 72.5 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF5055 PF16478.5 KOO36614.1 - 0.014 15.6 0.0 0.015 15.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5055) Lipase_GDSL_2 PF13472.6 KOO36617.1 - 6.7e-08 33.1 0.0 8.8e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KOO36617.1 - 0.0017 18.4 0.0 0.0023 18.0 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF5642 PF18702.1 KOO36617.1 - 0.086 12.6 0.1 0.26 11.1 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5642) Ank_2 PF12796.7 KOO36618.1 - 8.6e-07 29.5 2.4 1e-06 29.2 1.2 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Methyltransf_32 PF13679.6 KOO36618.1 - 4.8e-06 26.6 0.1 1.7e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ank_5 PF13857.6 KOO36618.1 - 0.00012 22.3 1.5 0.0011 19.2 0.6 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO36618.1 - 0.00023 21.3 0.3 0.26 12.0 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KOO36618.1 - 0.0011 19.3 2.3 0.27 11.7 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KOO36618.1 - 0.053 14.1 0.7 0.88 10.2 0.0 2.9 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Lipase_GDSL_2 PF13472.6 KOO36620.1 - 0.0011 19.4 0.0 0.0013 19.1 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KOO36620.1 - 0.11 12.4 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase UQ_con PF00179.26 KOO36621.1 - 7.6e-44 148.8 0.0 8.4e-44 148.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO36621.1 - 0.00075 19.2 0.0 0.00092 18.9 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KOO36621.1 - 0.057 13.7 0.0 0.072 13.4 0.0 1.4 1 1 0 1 1 1 0 RWD domain Pkinase_Tyr PF07714.17 KOO36623.1 - 1.2e-45 155.8 0.0 1.8e-45 155.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO36623.1 - 1.8e-42 145.5 0.0 8.6e-42 143.3 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO36623.1 - 4.5e-05 23.5 1.6 0.1 12.5 0.0 3.0 3 0 0 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO36623.1 - 0.00053 19.4 0.0 0.00085 18.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like ACT PF01842.25 KOO36623.1 - 0.001 18.8 0.1 0.0022 17.7 0.1 1.5 1 0 0 1 1 1 1 ACT domain Kdo PF06293.14 KOO36623.1 - 0.0028 17.0 0.0 0.005 16.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO36623.1 - 0.014 14.2 0.0 0.022 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase ACT_4 PF13291.6 KOO36623.1 - 0.048 14.3 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 ACT domain adh_short PF00106.25 KOO36692.1 - 1.1e-06 28.2 0.0 1.4e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOO36692.1 - 2.4e-06 27.3 0.0 3.4e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF2576 PF10845.8 KOO36694.1 - 0.055 13.1 0.1 12 5.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2576) IPPT PF01715.17 KOO36694.1 - 0.13 12.1 0.8 2.1 8.1 0.1 2.0 1 1 1 2 2 2 0 IPP transferase Tyr-DNA_phospho PF06087.12 KOO36695.1 - 4.1e-10 39.1 0.0 1.1e-08 34.5 0.0 2.0 1 1 1 2 2 2 2 Tyrosyl-DNA phosphodiesterase WWE PF02825.20 KOO36695.1 - 0.0008 20.0 0.1 0.0017 18.9 0.1 1.5 1 0 0 1 1 1 1 WWE domain Fib_alpha PF08702.10 KOO36696.1 - 0.0007 19.8 5.8 0.0007 19.8 5.8 7.8 2 1 5 8 8 8 2 Fibrinogen alpha/beta chain family Sterile PF03015.19 KOO36696.1 - 0.043 14.0 0.6 0.15 12.3 0.6 1.9 1 0 0 1 1 1 0 Male sterility protein PDZ PF00595.24 KOO36697.1 - 9.3e-05 22.7 0.0 0.29 11.5 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KOO36697.1 - 0.00036 20.3 0.2 1.2 9.0 0.1 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KOO36697.1 - 0.15 12.4 0.1 12 6.3 0.0 2.6 2 1 0 2 2 2 0 PDZ domain Cellulase PF00150.18 KOO36699.1 - 4.6e-18 65.6 0.0 1.3e-17 64.1 0.0 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 KOO36699.1 - 1.6e-11 44.5 0.1 2.8e-11 43.8 0.1 1.4 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Glyco_hydro_1 PF00232.18 KOO36699.1 - 0.00071 18.1 0.0 0.0011 17.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_42 PF02449.15 KOO36699.1 - 0.0018 17.7 0.0 0.018 14.4 0.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase DEAD PF00270.29 KOO36777.1 - 5.2e-13 49.1 0.0 8.1e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 KOO36777.1 - 5.1e-06 27.1 0.0 9.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 RecQ zinc-binding Phage_CII PF05269.11 KOO36777.1 - 0.028 14.6 0.0 0.093 13.0 0.0 1.9 1 0 0 1 1 1 0 Bacteriophage CII protein KH_1 PF00013.29 KOO36778.1 - 0.0028 17.4 0.0 0.0039 17.0 0.0 1.2 1 0 0 1 1 1 1 KH domain NAD_binding_10 PF13460.6 KOO36779.1 - 2.4e-26 92.7 3.4 4e-23 82.3 1.8 3.6 2 1 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 KOO36779.1 - 0.021 14.4 0.0 0.099 12.2 0.0 2.0 1 1 0 1 1 1 0 NmrA-like family DAHP_synth_2 PF01474.16 KOO36780.1 - 2.5e-148 494.2 0.0 8.2e-148 492.5 0.0 1.7 1 1 0 1 1 1 1 Class-II DAHP synthetase family U-box PF04564.15 KOO37054.1 - 3.3e-11 43.2 0.0 6.1e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.12 KOO37054.1 - 2.7e-10 40.6 9.2 4.7e-07 30.3 1.2 3.2 3 0 0 3 3 3 2 Sel1 repeat zf-Nse PF11789.8 KOO37054.1 - 0.0009 19.0 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO37054.1 - 0.0019 18.3 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein ELFV_dehydrog_N PF02812.18 KOO37059.1 - 0.042 13.7 0.0 0.46 10.4 0.0 2.3 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain YlbD_coat PF14071.6 KOO37061.1 - 0.04 14.2 0.0 0.66 10.2 0.0 2.0 2 0 0 2 2 2 0 Putative coat protein SET PF00856.28 KOO37062.1 - 1.3e-12 48.4 0.1 2.8e-12 47.4 0.1 1.5 1 1 0 1 1 1 1 SET domain SAF PF08666.12 KOO37062.1 - 0.011 16.3 0.1 0.44 11.2 0.1 2.4 2 0 0 2 2 2 0 SAF domain AA_permease_2 PF13520.6 KOO37064.1 - 4e-31 108.3 23.9 6.3e-31 107.6 23.6 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOO37064.1 - 1.9e-11 43.3 23.3 3.6e-11 42.3 23.2 1.4 1 1 0 1 1 1 1 Amino acid permease EF-hand_4 PF12763.7 KOO37064.1 - 4e-09 36.3 0.0 7.4e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 KOO37064.1 - 0.0044 16.5 0.0 0.013 15.0 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO37064.1 - 0.02 15.4 0.0 0.068 13.6 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair PH PF00169.29 KOO37064.1 - 0.027 15.0 0.0 0.06 13.9 0.0 1.6 1 0 0 1 1 1 0 PH domain EF-hand_6 PF13405.6 KOO37064.1 - 0.067 13.2 0.0 0.25 11.4 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain DUF1011 PF06237.12 KOO37064.1 - 0.33 11.3 3.6 1.8 8.9 3.6 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1011) CRAL_TRIO PF00650.20 KOO37065.1 - 1.1e-20 73.9 0.0 1.5e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Ank_2 PF12796.7 KOO37067.1 - 1.6e-69 230.5 37.7 1.7e-16 60.5 2.0 6.5 1 1 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO37067.1 - 1.2e-52 175.7 8.4 4.6e-10 39.8 0.1 8.4 3 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 KOO37067.1 - 4.4e-52 172.4 29.8 8e-06 26.1 0.1 11.7 12 0 0 12 12 12 9 Ankyrin repeat Ank_5 PF13857.6 KOO37067.1 - 1.1e-43 146.7 26.2 7.7e-09 35.6 0.1 9.2 2 1 8 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO37067.1 - 6.7e-41 133.6 11.0 0.0017 18.7 0.0 10.9 11 0 0 11 11 11 8 Ankyrin repeat U-box PF04564.15 KOO37067.1 - 1e-10 41.6 0.0 2e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 KOO37067.1 - 0.0034 17.5 0.0 0.0071 16.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KOO37067.1 - 0.0042 16.9 0.0 0.0086 15.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Mrr_cat PF04471.12 KOO37067.1 - 0.0044 17.0 0.7 2.7 8.1 0.1 2.7 2 1 0 2 2 2 2 Restriction endonuclease Ser_hydrolase PF06821.13 KOO37067.1 - 0.009 15.9 22.4 0.042 13.7 1.3 5.8 1 1 3 5 5 5 2 Serine hydrolase DUF4988 PF16378.5 KOO37067.1 - 0.014 15.1 1.0 0.34 10.5 0.1 3.2 1 1 3 4 4 4 0 Domain of unknown function PSII_Pbs31 PF18240.1 KOO37067.1 - 0.014 15.8 4.3 68 4.0 0.1 5.3 1 1 4 5 5 5 0 Photosystem II Psb31 protein Defensin_propep PF00879.18 KOO37067.1 - 0.058 13.7 0.8 19 5.6 0.1 3.0 2 0 0 2 2 2 0 Defensin propeptide DUF5583 PF17821.1 KOO37067.1 - 0.096 12.6 0.1 44 4.0 0.0 3.3 2 1 1 3 3 3 0 Family of unknown function (DUF5583) GFO_IDH_MocA PF01408.22 KOO37067.1 - 0.5 11.2 3.5 2.5 8.9 0.1 3.6 2 2 1 3 3 3 0 Oxidoreductase family, NAD-binding Rossmann fold VBS PF08913.10 KOO37067.1 - 0.55 10.7 14.7 14 6.2 0.3 4.4 1 1 3 4 4 4 0 Vinculin Binding Site PP_kinase_C_1 PF17941.1 KOO37067.1 - 1.3 8.5 19.3 6.9 6.2 0.1 6.5 2 1 7 9 9 9 0 Polyphosphate kinase C-terminal domain 1 Exotox-A_target PF09102.10 KOO37067.1 - 3.5 7.6 16.7 0.49 10.4 0.7 3.9 1 1 3 4 4 4 0 Exotoxin A, targeting ARL2_Bind_BART PF11527.8 KOO37068.1 - 2.9e-31 108.0 0.1 4.8e-31 107.3 0.1 1.4 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART Ank_5 PF13857.6 KOO37068.1 - 2.3e-07 30.9 0.0 1.3e-06 28.6 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO37068.1 - 4.8e-07 30.2 0.0 0.0011 19.4 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO37068.1 - 6.2e-07 29.9 0.0 1.5e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO37068.1 - 0.00011 22.5 0.0 0.01 16.2 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 KOO37068.1 - 0.00059 20.1 0.0 0.006 17.0 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat ATG16 PF08614.11 KOO37068.1 - 0.28 11.4 5.5 2.4 8.3 3.2 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) AhpC-TSA PF00578.21 KOO37069.1 - 1.6e-10 41.0 0.0 4.6e-10 39.5 0.0 1.7 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOO37069.1 - 1e-05 25.3 0.2 4.8e-05 23.1 0.2 1.8 1 1 0 1 1 1 1 Redoxin ABC1 PF03109.16 KOO37070.1 - 2.6e-28 98.6 0.0 6.6e-28 97.3 0.0 1.7 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO37070.1 - 1.9e-05 24.7 5.8 5.4e-05 23.2 0.0 3.5 3 1 1 4 4 4 1 Phosphotransferase enzyme family RIO1 PF01163.22 KOO37070.1 - 0.0028 17.3 0.0 0.029 14.0 0.0 2.1 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 KOO37070.1 - 0.01 15.2 0.0 0.068 12.5 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain Apolipoprotein PF01442.18 KOO37070.1 - 0.056 13.3 3.2 0.12 12.2 3.2 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF4432 PF14486.6 KOO37076.1 - 1.6e-100 335.8 0.0 2e-100 335.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4432) Hydrolase_4 PF12146.8 KOO37077.1 - 2e-11 43.6 0.4 2.2e-10 40.2 0.4 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOO37077.1 - 1e-09 39.3 4.9 2.5e-09 38.1 4.9 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO37077.1 - 6e-06 26.1 0.3 0.13 11.8 0.4 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOO37077.1 - 0.026 14.0 0.0 7.5 6.0 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family zf-RING_14 PF17978.1 KOO37078.1 - 4.1e-05 23.9 4.1 8.8e-05 22.9 4.1 1.5 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 KOO37078.1 - 8.3e-05 22.4 3.0 8.3e-05 22.4 3.0 3.0 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO37078.1 - 0.01 15.7 4.1 0.01 15.7 4.1 2.2 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 TIP120 PF08623.10 KOO37081.1 - 9.2e-55 185.0 2.0 2.9e-52 176.8 0.4 3.9 5 0 0 5 5 5 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 KOO37081.1 - 2.2e-09 37.6 25.5 0.01 16.2 0.0 7.7 6 2 2 8 8 8 3 HEAT repeats Adaptin_N PF01602.20 KOO37081.1 - 4.3e-09 35.5 6.9 0.00016 20.4 7.6 3.8 3 1 0 3 3 3 3 Adaptin N terminal region HEAT PF02985.22 KOO37081.1 - 2.2e-07 30.5 25.9 1.1 9.7 0.0 10.9 12 1 1 13 13 13 4 HEAT repeat HEAT_EZ PF13513.6 KOO37081.1 - 5.3e-07 30.0 39.1 0.31 11.6 0.1 12.4 9 4 4 13 13 13 4 HEAT-like repeat RIX1 PF08167.12 KOO37081.1 - 0.0061 16.3 9.8 0.28 10.9 0.4 4.2 3 1 0 3 3 3 2 rRNA processing/ribosome biogenesis Cnd1 PF12717.7 KOO37081.1 - 0.031 14.3 13.0 4.6 7.3 0.1 5.7 5 2 3 8 8 8 0 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.6 KOO37081.1 - 0.04 13.5 12.6 0.88 9.1 0.1 5.0 5 0 0 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II DNA_pol_phi PF04931.13 KOO37081.1 - 0.1 10.7 3.5 0.29 9.2 1.6 2.5 2 0 0 2 2 2 0 DNA polymerase phi Telomere_reg-2 PF10193.9 KOO37082.1 - 3.1e-05 24.4 1.0 0.36 11.3 0.1 3.2 2 1 1 3 3 3 2 Telomere length regulation protein MMS19_C PF12460.8 KOO37082.1 - 0.0016 17.7 0.0 0.014 14.5 0.0 2.3 2 1 1 3 3 3 1 RNAPII transcription regulator C-terminal FANCI_S2 PF14676.6 KOO37082.1 - 0.0021 18.4 0.0 4.1 7.7 0.0 3.3 2 1 0 3 3 3 1 FANCI solenoid 2 HEAT_2 PF13646.6 KOO37082.1 - 0.0038 17.6 1.2 3.5 8.1 0.0 3.3 3 2 0 3 3 3 2 HEAT repeats MMS19_N PF14500.6 KOO37082.1 - 0.0047 16.5 2.2 2.9 7.4 0.0 3.3 1 1 1 2 2 2 2 Dos2-interacting transcription regulator of RNA-Pol-II Adaptin_N PF01602.20 KOO37082.1 - 0.013 14.1 0.2 0.028 13.0 0.2 1.5 1 1 0 1 1 1 0 Adaptin N terminal region Xpo1 PF08389.12 KOO37082.1 - 0.026 14.6 0.0 4.4 7.3 0.0 2.9 3 0 0 3 3 3 0 Exportin 1-like protein RTP1_C1 PF10363.9 KOO37082.1 - 0.03 14.5 0.3 1.2 9.3 0.1 2.8 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 KOO37082.1 - 0.03 14.6 9.0 0.25 11.7 0.2 5.2 6 0 0 6 6 6 0 HEAT repeat Tti2 PF10521.9 KOO37082.1 - 0.04 13.5 0.1 2.9 7.3 0.0 2.3 1 1 1 2 2 2 0 Tti2 family Cnd1 PF12717.7 KOO37082.1 - 0.047 13.7 0.4 0.78 9.8 0.1 2.3 1 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 KOO37082.1 - 0.08 12.7 0.0 4.8 6.9 0.0 3.0 2 1 1 3 3 3 0 rRNA processing/ribosome biogenesis UTP15_C PF09384.10 KOO40303.1 - 0.023 14.4 0.1 3 7.5 0.0 3.4 3 0 0 3 3 3 0 UTP15 C terminal EH_Signature PF15611.6 KOO40303.1 - 0.037 13.5 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 EH_Signature domain DUF1804 PF08822.11 KOO40303.1 - 0.074 13.0 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) PKD_channel PF08016.12 KOO40304.1 - 5.5e-59 199.9 4.7 9.2e-59 199.2 4.7 1.4 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 KOO40304.1 - 3.3e-10 39.6 24.0 3.3e-10 39.6 24.0 1.9 2 0 0 2 2 2 1 Ion transport protein Ni_hydr_CYTB PF01292.20 KOO40304.1 - 0.16 11.5 5.3 0.43 10.1 5.3 1.8 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 PIN_12 PF16289.5 KOO40304.1 - 3.7 8.0 13.4 0.12 12.8 4.6 2.4 2 1 1 3 3 3 0 PIN domain Pho86 PF11124.8 KOO40304.1 - 4.2 6.7 11.9 9.1 5.6 5.3 2.6 2 0 0 2 2 2 0 Inorganic phosphate transporter Pho86 DDE_Tnp_1_6 PF13751.6 KOO40347.1 - 0.027 14.7 6.9 0.57 10.4 0.3 2.9 1 1 2 3 3 3 0 Transposase DDE domain CRAL_TRIO PF00650.20 KOO40348.1 - 6.3e-14 52.0 0.0 1e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Androgen_recep PF02166.16 KOO40348.1 - 0.074 11.9 2.1 0.14 11.0 2.1 1.4 1 0 0 1 1 1 0 Androgen receptor CRAL_TRIO_N PF03765.15 KOO40348.1 - 0.14 12.3 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain K_channel_TID PF07941.11 KOO40348.1 - 3.2 8.3 11.1 6.4 7.3 0.3 2.6 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain LRR_5 PF13306.6 KOO40349.1 - 6.6e-66 220.1 0.0 2.2e-34 118.2 0.2 2.5 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO40349.1 - 5.9e-14 51.6 0.0 0.034 13.9 0.0 6.7 2 1 7 9 9 9 8 Leucine rich repeat DUF3323 PF11796.8 KOO40349.1 - 0.4 10.5 10.5 0.069 13.0 3.5 2.1 1 1 1 2 2 2 0 Protein of unknown function N-terminus (DUF3323) LRR_5 PF13306.6 KOO40350.1 - 8.6e-100 329.6 0.1 5.4e-39 133.1 0.0 3.5 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO40350.1 - 6.7e-22 77.0 0.0 0.00027 20.6 0.0 7.9 1 1 9 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 KOO40350.1 - 0.012 16.0 4.3 2.2e+02 2.5 0.2 7.1 4 3 3 8 8 8 0 Leucine Rich repeats (2 copies) DUF1358 PF07096.11 KOO40350.1 - 0.042 13.8 1.1 0.17 11.9 0.4 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1358) He_PIG PF05345.12 KOO40350.1 - 0.068 13.4 18.1 76 3.6 0.1 8.9 10 0 0 10 10 10 0 Putative Ig domain Peptidase_M8 PF01457.16 KOO40350.1 - 0.88 8.2 2.2 29 3.2 0.0 3.4 2 2 1 4 4 4 0 Leishmanolysin Forkhead_N PF08430.12 KOO40350.1 - 1.1 9.8 14.9 62 4.2 6.9 3.4 1 1 1 2 2 2 0 Forkhead N-terminal region 2OG-FeII_Oxy_3 PF13640.6 KOO40351.1 - 2.4e-14 54.0 0.0 4.7e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DDE_Tnp_1_6 PF13751.6 KOO40352.1 - 0.72 10.1 14.1 1.1 9.5 0.7 2.9 1 1 2 3 3 3 0 Transposase DDE domain AAA_33 PF13671.6 KOO40402.1 - 1.8e-05 24.9 0.1 1.8e-05 24.9 0.1 3.1 3 1 1 4 4 4 1 AAA domain Zeta_toxin PF06414.12 KOO40402.1 - 0.00022 20.6 0.0 0.0013 18.1 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin APS_kinase PF01583.20 KOO40402.1 - 0.0051 16.7 0.7 0.011 15.6 0.1 1.8 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_18 PF13238.6 KOO40402.1 - 0.014 15.9 0.7 0.057 14.0 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KOO40402.1 - 0.017 15.6 0.0 0.04 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOO40402.1 - 0.022 13.8 1.3 0.033 13.2 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein RsgA_GTPase PF03193.16 KOO40402.1 - 0.028 14.3 0.1 0.066 13.1 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase Cytidylate_kin PF02224.18 KOO40402.1 - 0.038 13.7 0.1 0.038 13.7 0.1 1.9 2 0 0 2 2 2 0 Cytidylate kinase AAA_28 PF13521.6 KOO40402.1 - 0.038 14.2 0.3 0.096 12.9 0.3 1.7 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KOO40402.1 - 0.05 13.5 0.5 0.1 12.5 0.0 1.6 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_29 PF13555.6 KOO40402.1 - 0.068 12.9 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 KOO40402.1 - 0.083 13.3 3.4 0.12 12.7 0.1 2.6 2 1 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 KOO40402.1 - 0.12 11.6 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.27 KOO40402.1 - 0.13 12.8 0.5 0.39 11.2 0.1 1.9 2 0 0 2 2 2 0 ABC transporter TsaE PF02367.17 KOO40402.1 - 0.15 12.1 0.1 0.31 11.0 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 KOO40402.1 - 0.34 11.2 1.8 1.4 9.2 0.1 2.6 2 1 0 3 3 3 0 AAA domain DUF563 PF04577.14 KOO40403.1 - 6.8e-15 55.8 0.2 1.2e-14 55.0 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Pkinase PF00069.25 KOO40404.1 - 2.2e-43 148.5 0.0 4.9e-43 147.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO40404.1 - 4.5e-42 144.1 0.0 1.1e-41 142.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 KOO40404.1 - 3.2e-20 72.5 0.1 3.7e-11 43.4 0.0 2.8 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO40404.1 - 7.2e-18 64.7 0.0 1.9e-06 28.3 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOO40404.1 - 1.8e-14 53.4 1.3 0.0028 18.0 0.1 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KOO40404.1 - 8.1e-14 51.5 0.4 6.7e-06 26.3 0.1 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO40404.1 - 3.5e-09 36.2 0.0 0.099 13.3 0.0 5.0 4 0 0 4 4 4 2 Ankyrin repeat APH PF01636.23 KOO40404.1 - 0.0021 18.0 0.1 0.017 15.0 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family EF-hand_6 PF13405.6 KOO40407.1 - 6.8e-24 81.7 9.3 7.3e-05 22.4 0.0 7.0 7 0 0 7 7 7 4 EF-hand domain EF-hand_1 PF00036.32 KOO40407.1 - 2.5e-23 79.8 4.6 0.00023 20.5 0.1 6.4 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.6 KOO40407.1 - 1.3e-21 76.8 10.3 1.9e-09 37.8 0.3 3.7 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO40407.1 - 5e-16 58.3 6.6 5.4e-06 26.2 0.1 4.7 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO40407.1 - 3.1e-14 51.7 14.2 0.00015 21.1 0.1 5.6 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 KOO40407.1 - 5e-05 23.6 0.1 1.9 8.8 0.0 4.6 4 2 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KOO40407.1 - 0.00069 20.5 0.0 1.2 10.1 0.0 3.4 3 0 0 3 3 3 1 EF-hand domain Peptidase_C26 PF07722.13 KOO40408.1 - 2.2e-12 47.2 0.0 9.5e-11 41.9 0.0 2.7 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 KOO40408.1 - 8.1e-08 32.3 0.0 1.4e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Cupin_8 PF13621.6 KOO40409.1 - 0.077 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Cupin-like domain ILEI PF15711.5 KOO40423.1 - 0.0019 18.6 0.0 0.0039 17.6 0.0 1.5 1 0 0 1 1 1 1 Interleukin-like EMT inducer GcrA PF07750.11 KOO40683.1 - 0.26 11.7 1.9 0.5 10.8 1.0 1.9 2 0 0 2 2 2 0 GcrA cell cycle regulator DnaG_DnaB_bind PF08278.11 KOO40683.1 - 0.34 11.5 6.2 4.7 7.8 6.2 2.2 1 1 0 1 1 1 0 DNA primase DnaG DnaB-binding N6-adenineMlase PF10237.9 KOO40684.1 - 5.6e-26 91.3 0.0 8.9e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Nucleotid_trans PF03407.16 KOO40684.1 - 7.7e-13 48.9 0.0 2e-12 47.6 0.0 1.7 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase Tmemb_185A PF10269.9 KOO40685.1 - 2.2e-07 30.8 1.1 3.8e-07 30.0 1.1 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein ResIII PF04851.15 KOO40685.1 - 0.00014 21.9 0.0 0.0011 19.0 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO40685.1 - 0.00046 20.0 0.0 0.0012 18.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD_C_2 PF13538.6 KOO40685.1 - 0.0013 18.6 0.2 0.0064 16.3 0.1 2.4 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 KOO40685.1 - 0.0087 16.3 0.0 0.069 13.4 0.0 2.5 3 0 0 3 3 3 1 AAA domain DUF2075 PF09848.9 KOO40685.1 - 0.058 12.6 0.0 0.13 11.4 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) LAM_C PF12544.8 KOO40685.1 - 0.2 11.8 0.0 0.44 10.7 0.0 1.4 1 0 0 1 1 1 0 Lysine-2,3-aminomutase RAP1 PF07218.11 KOO40685.1 - 1.2 7.4 4.7 2.2 6.5 4.7 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PABP PF00658.18 KOO40835.1 - 3.7e-08 33.4 0.0 8.2e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain CpcD PF01383.21 KOO41037.1 - 0.099 12.9 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 CpcD/allophycocyanin linker domain DUF3399 PF11879.8 KOO41263.1 - 9.6 6.6 10.6 11 6.5 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) zf-C2H2 PF00096.26 KOO41264.1 - 1.8e-30 103.6 53.0 1.6e-05 25.1 2.4 6.4 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO41264.1 - 1.2e-24 85.5 48.7 2.6e-06 27.6 2.1 7.0 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO41264.1 - 4.3e-20 70.7 45.2 0.0037 18.0 0.6 6.4 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOO41264.1 - 7.4e-07 29.0 38.6 0.064 13.3 1.2 6.5 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOO41264.1 - 0.0038 17.5 23.4 1.1 9.6 0.3 6.3 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding CHORD PF04968.12 KOO41264.1 - 0.0043 17.7 41.7 0.92 10.3 0.9 6.4 1 1 5 6 6 6 4 CHORD zf-LYAR PF08790.11 KOO41264.1 - 0.23 11.4 12.6 21 5.1 0.1 6.0 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger zf-C2H2_aberr PF17017.5 KOO41264.1 - 2.1 8.5 24.7 3.9 7.6 2.0 5.7 2 1 2 6 6 6 0 Aberrant zinc-finger LRR_6 PF13516.6 KOO41266.1 - 1.5e-11 43.3 0.6 8.6e-05 22.3 0.0 3.4 3 0 0 3 3 3 3 Leucine Rich repeat Galactosyl_T PF01762.21 KOO41268.1 - 9.1e-06 25.6 0.0 3e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 Galactosyltransferase DUF1287 PF06940.11 KOO41268.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) NLPC_P60 PF00877.19 KOO41268.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 NlpC/P60 family Fringe PF02434.16 KOO41268.1 - 0.22 10.9 0.0 0.62 9.4 0.0 1.6 1 1 0 1 1 1 0 Fringe-like Spc7_N PF15402.6 KOO41877.1 - 1.1e-05 24.0 0.1 1.3e-05 23.8 0.1 1.1 1 0 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 BSD PF03909.17 KOO41878.1 - 3.8e-06 26.8 0.0 1.2e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 BSD domain UVR PF02151.19 KOO41878.1 - 0.0024 17.6 1.7 0.0024 17.6 1.7 2.1 2 0 0 2 2 2 1 UvrB/uvrC motif TAL_FSA PF00923.19 KOO41879.1 - 6.9e-76 255.3 0.0 1.4e-75 254.3 0.0 1.5 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Peptidase_C54 PF03416.19 KOO41880.1 - 4.5e-39 134.5 0.0 5.7e-39 134.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 UAA PF08449.11 KOO41881.1 - 3e-08 33.2 12.6 4.1e-08 32.8 12.6 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 KOO41881.1 - 3e-05 23.5 14.3 4e-05 23.1 14.3 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO41881.1 - 0.0088 16.2 32.1 0.068 13.3 11.2 2.1 2 0 0 2 2 2 2 EamA-like transporter family SET_assoc PF11767.8 KOO41958.1 - 0.016 14.8 0.0 5.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Pkinase PF00069.25 KOO42294.1 - 4.8e-52 176.9 0.0 6e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO42294.1 - 7.1e-23 81.2 0.0 1e-22 80.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO42294.1 - 0.013 14.3 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 KOO42294.1 - 0.039 13.3 0.0 0.11 11.8 0.0 1.7 1 1 0 1 1 1 0 Kinase-like FTA2 PF13095.6 KOO42294.1 - 0.18 11.4 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Cons_hypoth95 PF03602.15 KOO42295.1 - 6.4e-06 25.9 0.0 9.2e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 KOO42295.1 - 1.1e-05 25.2 0.0 1.6e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO42295.1 - 0.00019 20.9 0.0 0.00025 20.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 KOO42295.1 - 0.0014 18.3 0.1 0.017 14.8 0.1 2.5 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 KOO42295.1 - 0.0016 19.1 0.0 0.0038 17.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOO42295.1 - 0.003 17.1 0.0 0.042 13.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltrans_SAM PF10672.9 KOO42295.1 - 0.04 13.1 0.0 0.07 12.3 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase N6_N4_Mtase PF01555.18 KOO42295.1 - 0.089 12.5 0.0 1.6 8.4 0.0 2.0 2 0 0 2 2 2 0 DNA methylase N6_Mtase PF02384.16 KOO42295.1 - 0.3 10.3 0.0 0.36 10.1 0.0 1.1 1 0 0 1 1 1 0 N-6 DNA Methylase PIF1 PF05970.14 KOO42296.1 - 5.8e-52 177.1 1.3 7.5e-40 137.2 0.1 2.9 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 KOO42296.1 - 3.3e-23 82.4 0.3 1e-22 80.8 0.0 1.9 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.6 KOO42296.1 - 6.5e-15 55.7 0.0 1.4e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOO42296.1 - 5.6e-07 29.9 0.3 1.7e-06 28.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KOO42296.1 - 8.8e-05 22.4 0.3 0.0045 16.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOO42296.1 - 0.00046 20.6 0.5 0.0022 18.4 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 KOO42296.1 - 0.00048 19.3 0.0 0.00092 18.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein Mg_chelatase PF01078.21 KOO42296.1 - 0.00049 19.5 0.1 0.0009 18.7 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI UvrD-helicase PF00580.21 KOO42296.1 - 0.00091 18.8 0.6 0.0013 18.3 0.6 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 KOO42296.1 - 0.0071 16.2 0.4 0.066 13.1 0.4 2.1 1 1 0 1 1 1 1 Helicase AAA PF00004.29 KOO42296.1 - 0.0077 16.7 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.9 KOO42296.1 - 0.01 14.8 0.4 0.021 13.8 0.4 1.5 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain DEAD PF00270.29 KOO42296.1 - 0.011 15.5 0.3 2.2 8.0 0.1 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_5 PF07728.14 KOO42296.1 - 0.015 15.3 0.0 0.037 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 KOO42296.1 - 0.03 13.6 0.2 0.045 13.0 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 KOO42296.1 - 0.035 13.6 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 KOO42296.1 - 0.039 13.9 0.1 0.32 10.9 0.0 2.4 3 0 0 3 3 3 0 NTPase PhoH PF02562.16 KOO42296.1 - 0.049 13.1 0.2 0.11 12.0 0.2 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 KOO42296.1 - 0.065 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOO42296.1 - 0.066 13.1 0.0 0.2 11.6 0.0 1.8 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 KOO42296.1 - 0.088 13.2 0.0 0.18 12.2 0.0 1.6 1 1 0 1 1 1 0 RNA helicase Hpr_kinase_C PF07475.12 KOO42296.1 - 0.15 11.6 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain ABC_tran PF00005.27 KOO42296.1 - 0.16 12.5 0.1 0.28 11.7 0.1 1.4 1 0 0 1 1 1 0 ABC transporter DAP3 PF10236.9 KOO42296.1 - 0.16 11.1 0.0 0.38 9.9 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_32 PF13654.6 KOO42296.1 - 0.17 10.6 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KOO42296.1 - 0.21 11.5 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DASH_Spc34 PF08657.10 KOO42607.1 - 0.034 13.9 0.0 0.046 13.5 0.0 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 LRR_5 PF13306.6 KOO42683.1 - 3.9e-116 382.5 0.1 7.7e-40 135.8 0.1 2.7 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO42683.1 - 1.4e-19 69.6 0.0 0.0016 18.2 0.0 6.7 2 1 7 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 KOO42683.1 - 0.0086 16.5 0.0 1.6e+02 2.9 0.0 6.1 4 1 2 7 7 7 0 Leucine Rich repeats (2 copies) Forkhead_N PF08430.12 KOO42683.1 - 0.097 13.3 9.2 2.2 8.9 4.4 3.1 1 1 0 2 2 2 0 Forkhead N-terminal region Peptidase_M8 PF01457.16 KOO42683.1 - 0.39 9.3 1.5 23 3.5 0.1 3.0 2 1 2 4 4 4 0 Leishmanolysin He_PIG PF05345.12 KOO42683.1 - 2.4 8.4 18.9 1.1e+02 3.1 0.0 7.6 6 2 0 7 7 7 0 Putative Ig domain DDE_Tnp_1_6 PF13751.6 KOO42684.1 - 1.1 9.5 15.6 4.2 7.6 0.8 4.6 1 1 4 5 5 5 0 Transposase DDE domain ADK PF00406.22 KOO42685.1 - 8.7e-53 178.5 0.0 1.2e-52 178.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO42685.1 - 6.1e-25 88.2 0.0 1.4e-24 87.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 KOO42685.1 - 6.6e-14 51.6 0.0 1.4e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 KOO42685.1 - 5.5e-05 23.5 1.4 0.0065 16.8 0.1 2.7 2 1 1 3 3 3 2 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 KOO42685.1 - 0.00041 20.9 0.0 0.00075 20.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOO42685.1 - 0.013 15.7 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 KOO42685.1 - 0.045 13.5 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase EF-hand_1 PF00036.32 KOO43075.1 - 2.1e-22 76.9 27.8 1e-05 24.7 0.5 6.7 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO43075.1 - 5.6e-20 71.6 19.2 9.6e-07 29.2 2.8 5.2 2 1 3 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.6 KOO43075.1 - 1.5e-19 68.2 22.9 0.00016 21.3 0.2 6.7 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.6 KOO43075.1 - 3.4e-17 62.0 7.0 1e-06 28.5 0.1 4.5 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO43075.1 - 7.5e-08 31.5 26.0 0.0021 17.5 0.3 6.0 6 0 0 6 6 6 3 EF hand DSS1_SEM1 PF05160.13 KOO43075.1 - 0.00047 20.2 8.7 7.2 6.8 0.0 7.7 7 0 0 7 7 7 2 DSS1/SEM1 family SNARE PF05739.19 KOO43075.1 - 0.17 11.9 2.9 0.51 10.4 0.4 3.4 2 0 0 2 2 2 0 SNARE domain DAGAT PF03982.13 KOO43076.1 - 8.9e-29 100.3 0.0 3.1e-28 98.5 0.0 1.7 2 0 0 2 2 2 1 Diacylglycerol acyltransferase PsbQ PF05757.11 KOO43077.1 - 0.049 13.4 5.5 0.089 12.5 2.4 2.1 1 1 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) PRP38 PF03371.15 KOO43088.1 - 6.2e-52 176.0 0.1 8.1e-52 175.6 0.1 1.1 1 0 0 1 1 1 1 PRP38 family eRF1_1 PF03463.15 KOO43089.1 - 2e-41 141.0 0.0 2.4e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 KOO43089.1 - 5.6e-11 42.9 0.0 9.8e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 ParcG PF10274.9 KOO43090.1 - 4e-27 95.5 0.0 5e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein NDK PF00334.19 KOO43091.1 - 1.2e-06 28.6 0.0 0.00029 20.9 0.0 2.1 1 1 1 2 2 2 2 Nucleoside diphosphate kinase Profilin PF00235.19 KOO43434.1 - 0.069 13.4 0.2 0.13 12.5 0.2 1.4 1 0 0 1 1 1 0 Profilin PDZ PF00595.24 KOO43557.1 - 2e-07 31.3 0.0 0.002 18.4 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KOO43557.1 - 0.0009 19.0 0.0 0.16 11.8 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KOO43557.1 - 0.012 15.9 0.0 0.12 12.8 0.0 2.2 2 0 0 2 2 2 0 PDZ domain Apolipoprotein PF01442.18 KOO43558.1 - 0.0064 16.4 6.5 0.0064 16.4 6.5 2.3 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain SLAIN PF15301.6 KOO43558.1 - 0.01 15.1 0.1 0.01 15.1 0.1 1.7 2 0 0 2 2 2 0 SLAIN motif-containing family DNA_pol_B_thumb PF14791.6 KOO43558.1 - 0.02 15.0 0.0 0.055 13.6 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase beta thumb SHOCT PF09851.9 KOO43559.1 - 0.00024 20.7 8.9 0.00033 20.3 8.9 1.2 1 0 0 1 1 1 1 Short C-terminal domain GvpG PF05120.12 KOO43559.1 - 0.032 14.2 0.1 0.052 13.6 0.1 1.2 1 0 0 1 1 1 0 Gas vesicle protein G Mito_carr PF00153.27 KOO43560.1 - 1.5e-60 201.1 1.3 5.4e-19 67.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 KOO43560.1 - 6.8e-21 74.5 0.1 2.2e-11 44.0 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO43560.1 - 2.3e-14 51.8 0.1 0.00014 21.1 0.7 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOO43560.1 - 2.6e-12 45.6 0.2 0.011 15.6 0.0 4.0 3 1 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KOO43560.1 - 2.1e-11 43.5 0.1 0.0062 16.4 0.0 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO43560.1 - 4e-11 41.9 0.6 0.00048 19.5 0.2 3.5 3 0 0 3 3 3 3 EF hand SPARC_Ca_bdg PF10591.9 KOO43560.1 - 0.0003 21.1 0.0 0.034 14.5 0.0 2.2 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO43560.1 - 0.014 15.3 0.0 5.8 6.9 0.0 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand UVR PF02151.19 KOO43760.1 - 2.8e-10 39.6 27.0 0.0004 20.0 6.0 3.5 3 0 0 3 3 3 3 UvrB/uvrC motif Rubredoxin_C PF18267.1 KOO43760.1 - 1.6e-06 27.9 1.5 0.43 10.5 0.1 3.4 3 0 0 3 3 3 2 Rubredoxin NAD+ reductase C-terminal domain YqaH PF17448.2 KOO43760.1 - 0.0094 16.2 7.5 2.6 8.4 0.3 3.4 1 1 2 3 3 3 2 Uncharacterized YqaH-like Spc7 PF08317.11 KOO43760.1 - 0.093 11.6 8.4 0.12 11.2 8.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Lipoprotein_11 PF03260.13 KOO43760.1 - 0.14 11.5 6.6 6.3 6.1 1.4 3.0 1 1 2 3 3 3 0 Lepidopteran low molecular weight (30 kD) lipoprotein ABC_tran_CTD PF16326.5 KOO43760.1 - 0.23 11.7 22.3 0.5 10.7 2.5 3.3 1 1 2 3 3 3 0 ABC transporter C-terminal domain DUF1464 PF07318.12 KOO43760.1 - 0.28 10.3 5.7 1.9 7.5 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1464) CsgA PF17334.2 KOO43760.1 - 0.44 11.3 3.3 3.6 8.4 0.6 2.4 1 1 1 2 2 2 0 Minor curli fiber component A T3SS_needle_E PF08988.10 KOO43760.1 - 0.62 10.3 10.9 3.7 7.8 2.9 3.0 1 1 1 2 2 2 0 Type III secretion system, cytoplasmic E component of needle DUF1090 PF06476.12 KOO43760.1 - 0.89 9.7 14.0 0.86 9.7 6.9 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1090) Reductase_C PF14759.6 KOO43760.1 - 1.3 9.7 3.7 7.2 7.2 0.2 2.9 1 1 2 3 3 3 0 Reductase C-terminal PCRF PF03462.18 KOO43760.1 - 1.3 8.9 9.2 0.24 11.2 4.6 1.9 1 1 1 2 2 2 0 PCRF domain DUF4404 PF14357.6 KOO43760.1 - 5.6 7.7 9.5 17 6.2 3.0 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) TRM13 PF05206.14 KOO43761.1 - 2.7e-59 200.8 0.0 2.3e-43 148.6 0.0 2.0 2 0 0 2 2 2 2 Methyltransferase TRM13 Methyltransf_32 PF13679.6 KOO43761.1 - 0.008 16.2 6.4 0.06 13.3 6.4 2.2 1 1 0 1 1 1 1 Methyltransferase domain His_Phos_1 PF00300.22 KOO43762.1 - 1.5e-09 37.8 5.5 2.4e-05 24.1 0.1 3.2 3 0 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) Peptidase_S8 PF00082.22 KOO44189.1 - 3.8e-21 75.6 11.4 1e-19 71.0 11.4 2.6 1 1 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KOO44189.1 - 6.3e-08 32.5 0.1 2.8e-07 30.5 0.0 2.0 2 0 0 2 2 2 1 Proprotein convertase P-domain DUF1823 PF08853.11 KOO44196.1 - 1.1e-37 128.7 0.3 2e-37 127.8 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1823) PH PF00169.29 KOO44196.1 - 1.7e-06 28.5 0.0 3.7e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 PH domain DNTTIP1_dimer PF18192.1 KOO44196.1 - 0.1 13.0 0.4 0.85 10.0 0.0 2.6 3 0 0 3 3 3 0 DNTTIP1 dimerisation domain ABC2_membrane_3 PF12698.7 KOO44197.1 - 3.2e-51 174.5 34.4 6e-33 114.4 13.8 2.8 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 KOO44197.1 - 1e-46 158.8 0.0 1.4e-22 80.7 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO44197.1 - 2.9e-19 70.0 0.9 4.6e-06 26.7 0.0 5.0 5 0 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KOO44197.1 - 0.00072 20.1 3.3 0.022 15.3 0.1 2.2 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 KOO44197.1 - 0.0025 18.0 0.0 6.1 7.2 0.0 3.2 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 KOO44197.1 - 0.0034 17.0 1.4 1.3 8.6 0.1 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_30 PF13604.6 KOO44197.1 - 0.012 15.3 0.4 0.41 10.3 0.0 2.8 2 1 0 2 2 2 0 AAA domain SMC_N PF02463.19 KOO44197.1 - 0.026 14.0 0.0 10 5.5 0.0 2.8 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain FAM181 PF15238.6 KOO44197.1 - 0.045 13.6 1.2 0.079 12.8 1.2 1.3 1 0 0 1 1 1 0 FAM181 AAA_29 PF13555.6 KOO44197.1 - 0.073 12.8 3.0 0.49 10.2 0.3 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_15 PF13175.6 KOO44197.1 - 0.15 11.8 0.3 2 8.1 0.1 2.5 3 0 0 3 3 3 0 AAA ATPase domain UDPGP PF01704.18 KOO44198.1 - 1.2e-117 393.0 0.0 1.5e-117 392.8 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Dpy-30 PF05186.13 KOO44198.1 - 0.00012 21.7 0.1 0.00044 19.9 0.0 2.0 2 0 0 2 2 2 1 Dpy-30 motif EF-hand_1 PF00036.32 KOO44199.1 - 1e-11 43.5 3.0 2.3e-06 26.7 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO44199.1 - 1.4e-09 37.1 1.1 0.00093 18.9 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO44199.1 - 9.8e-09 35.6 2.0 0.0015 18.9 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO44199.1 - 8.2e-08 31.4 2.7 0.001 18.5 0.4 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO44199.1 - 1.4e-07 31.2 10.8 1.8e-07 30.9 0.2 2.9 2 1 1 3 3 3 2 EF-hand domain pair p25-alpha PF05517.12 KOO44199.1 - 0.0079 16.4 0.0 0.014 15.5 0.0 1.5 1 1 0 1 1 1 1 p25-alpha Barttin PF15462.6 KOO44199.1 - 0.053 13.3 0.0 0.067 13.0 0.0 1.1 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) ADH_zinc_N PF00107.26 KOO44200.1 - 4.1e-11 43.0 1.6 1.8e-10 40.9 0.2 2.5 3 0 0 3 3 3 1 Zinc-binding dehydrogenase KR PF08659.10 KOO44200.1 - 0.00042 20.3 0.5 0.00073 19.5 0.5 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 KOO44200.1 - 0.00098 18.6 0.5 0.0018 17.7 0.5 1.4 1 0 0 1 1 1 1 short chain dehydrogenase ADH_N PF08240.12 KOO44200.1 - 0.0011 18.8 0.1 0.009 15.9 0.1 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain C2 PF00168.30 KOO44201.1 - 5.2e-18 65.2 0.0 5.1e-17 62.0 0.0 2.1 2 0 0 2 2 2 1 C2 domain CDK2AP PF09806.9 KOO44201.1 - 2.4 8.1 14.9 4.2 7.4 2.1 3.4 3 0 0 3 3 3 0 Cyclin-dependent kinase 2-associated protein Nuc_sug_transp PF04142.15 KOO44202.1 - 6.5e-52 176.6 2.2 1.1e-51 175.9 2.2 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO44202.1 - 0.0029 17.8 4.9 0.0029 17.8 4.9 2.3 2 0 0 2 2 2 1 EamA-like transporter family DUF4133 PF13571.6 KOO44202.1 - 0.03 14.7 3.0 6.7 7.1 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) TPT PF03151.16 KOO44202.1 - 0.05 12.9 6.0 0.029 13.7 2.0 2.1 2 1 0 2 2 2 0 Triose-phosphate Transporter family Imm_superinfect PF14373.6 KOO44202.1 - 0.63 10.0 4.0 1.6 8.7 4.0 1.7 1 0 0 1 1 1 0 Superinfection immunity protein OAD_gamma PF04277.13 KOO44203.1 - 0.088 13.4 1.8 0.27 11.9 1.8 1.9 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain PIN_8 PF18476.1 KOO44203.1 - 3.6 7.4 11.6 1.2 9.0 4.9 2.1 2 0 0 2 2 2 0 PIN like domain V_ATPase_I PF01496.19 KOO44203.1 - 8.9 4.1 9.3 7.8 4.3 7.3 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DDE_Tnp_ISL3 PF01610.17 KOO44203.1 - 9.7 5.8 11.4 0.34 10.6 5.2 1.7 2 0 0 2 2 2 0 Transposase NACHT PF05729.12 KOO44367.1 - 0.0022 17.9 0.1 0.006 16.5 0.1 1.8 1 0 0 1 1 1 1 NACHT domain Ank_2 PF12796.7 KOO45986.1 - 2.6e-78 258.6 31.9 2.3e-16 60.1 0.3 5.2 1 1 7 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO45986.1 - 1.2e-33 115.0 19.0 4.9e-07 30.2 0.1 7.5 4 2 5 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO45986.1 - 2.3e-29 101.1 16.1 2e-08 34.3 0.5 7.6 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO45986.1 - 1.8e-24 83.1 17.3 0.0092 16.4 0.1 8.9 9 0 0 9 9 9 7 Ankyrin repeat Ank PF00023.30 KOO45986.1 - 5.4e-22 77.2 32.4 0.0047 17.3 0.2 8.5 8 0 0 8 8 8 7 Ankyrin repeat Ank_2 PF12796.7 KOO45987.1 - 4.4e-121 395.7 38.2 1.2e-15 57.8 0.5 10.4 1 1 9 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO45987.1 - 6.3e-87 284.9 30.6 5.2e-09 36.5 0.1 14.4 9 5 7 16 16 16 15 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO45987.1 - 9.6e-79 258.4 48.7 2e-08 34.3 0.3 16.8 2 2 14 17 17 17 17 Ankyrin repeats (many copies) Ank PF00023.30 KOO45987.1 - 9.2e-57 187.2 89.3 0.00044 20.6 0.2 20.4 20 0 0 20 20 20 18 Ankyrin repeat Ank_3 PF13606.6 KOO45987.1 - 1.3e-53 172.7 42.3 0.003 17.9 0.0 19.8 20 0 0 20 20 20 16 Ankyrin repeat SR1P PF13790.6 KOO45987.1 - 0.016 15.3 12.8 18 5.5 0.0 8.2 10 0 0 10 10 10 0 SR1 protein DUF5336 PF17270.2 KOO45989.1 - 4.6 6.8 6.9 24 4.5 0.1 3.6 3 1 1 4 4 4 0 Family of unknown function (DUF5336) Mg_trans_NIPA PF05653.14 KOO45990.1 - 8.4e-15 54.6 11.8 1.2e-14 54.1 11.8 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA Ribosomal_L50 PF10501.9 KOO45991.1 - 2e-05 24.7 0.0 3.1e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal subunit 39S DUF1918 PF08940.11 KOO45991.1 - 0.11 12.1 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) DUF3082 PF11282.8 KOO45992.1 - 7.9e-11 42.0 3.5 1.1e-10 41.5 3.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3082) Bac_export_2 PF01312.19 KOO45992.1 - 0.016 14.5 0.0 0.021 14.0 0.0 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family 2OG-FeII_Oxy_3 PF13640.6 KOO45993.1 - 9.1e-10 39.3 0.2 1.4e-05 25.9 0.0 2.6 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily Costars PF14705.6 KOO45995.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Costars DUF834 PF05754.14 KOO45997.1 - 0.0037 17.3 4.0 1.7 8.7 0.1 3.9 3 0 0 3 3 3 2 Domain of unknown function (DUF834) LRR_6 PF13516.6 KOO45997.1 - 0.0049 16.8 0.3 10 6.5 0.0 3.6 4 0 0 4 4 4 2 Leucine Rich repeat PapC_C PF13953.6 KOO45997.1 - 0.068 13.0 2.0 9.4 6.1 0.0 3.0 3 0 0 3 3 3 0 PapC C-terminal domain VacA2 PF03077.14 KOO45997.1 - 0.12 12.2 0.3 17 5.3 0.1 2.6 2 0 0 2 2 2 0 Putative vacuolating cytotoxin AAA_27 PF13514.6 KOO45997.1 - 5.7 6.5 6.0 20 4.7 0.7 2.7 2 0 0 2 2 2 0 AAA domain mTERF PF02536.14 KOO45999.1 - 3.1e-18 65.8 0.0 3e-17 62.5 0.0 2.1 1 1 0 1 1 1 1 mTERF ArsC PF03960.15 KOO45999.1 - 1.1 9.4 4.4 72 3.5 0.1 3.9 4 1 1 5 5 5 0 ArsC family Gp_dh_C PF02800.20 KOO46000.1 - 3.2e-62 208.8 0.5 5.2e-62 208.1 0.1 1.5 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KOO46000.1 - 4.3e-32 110.4 0.0 1.5e-31 108.7 0.0 1.9 3 0 0 3 3 3 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 KOO46000.1 - 0.067 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ENTH PF01417.20 KOO46001.1 - 7.9e-20 71.2 0.1 1.1e-19 70.7 0.1 1.1 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 KOO46001.1 - 0.00015 20.9 0.0 0.00019 20.5 0.0 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 KOO46002.1 - 0.0016 18.5 0.2 0.0025 17.9 0.0 1.4 2 0 0 2 2 2 1 ENTH domain EF-hand_6 PF13405.6 KOO46004.1 - 4.6e-08 32.4 3.9 0.0034 17.2 0.2 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 KOO46004.1 - 6.9e-08 32.8 6.3 0.014 15.9 0.1 3.8 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 KOO46004.1 - 6.7e-07 28.4 7.3 0.0034 16.8 0.4 3.9 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO46004.1 - 3.4e-05 23.6 1.0 0.32 10.9 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO46004.1 - 0.047 13.2 2.4 0.88 9.2 0.3 2.9 3 0 0 3 3 3 0 EF hand LuxC PF05893.14 KOO46004.1 - 0.067 12.2 0.8 0.099 11.7 0.8 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) ERM PF00769.19 KOO46004.1 - 0.6 9.9 17.2 0.28 11.0 4.8 2.4 3 0 0 3 3 3 0 Ezrin/radixin/moesin family DUF1840 PF08895.11 KOO46004.1 - 2.3 8.6 7.1 1.6 9.1 1.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1840) Dus PF01207.17 KOO46006.1 - 5.2e-47 160.5 0.0 6.8e-47 160.1 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 KOO46006.1 - 0.00013 21.5 0.0 0.00022 20.8 0.0 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein zf-CCCH PF00642.24 KOO46006.1 - 0.0023 17.8 0.4 0.0054 16.6 0.4 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KOO46006.1 - 0.093 12.6 1.4 0.22 11.4 1.4 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger UFC1 PF08694.11 KOO46007.1 - 4.6e-67 224.5 0.2 5.2e-67 224.3 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 KOO46007.1 - 0.059 13.7 0.0 0.068 13.5 0.0 1.2 1 0 0 1 1 1 0 RWD domain Mod_r PF07200.13 KOO46008.1 - 0.16 12.1 0.6 0.34 11.0 0.6 1.5 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Kinesin PF00225.23 KOO46009.1 - 1.1e-26 93.5 0.0 1.6e-25 89.8 0.0 2.0 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO46009.1 - 0.00053 20.0 0.0 0.00073 19.5 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding EF-hand_6 PF13405.6 KOO46010.1 - 3.4e-09 35.9 5.0 0.00079 19.2 0.5 3.1 3 0 0 3 3 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO46010.1 - 5.6e-09 34.9 4.4 0.00039 19.8 0.5 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO46010.1 - 1.2e-08 34.7 1.5 0.00015 21.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KOO46010.1 - 1.4e-08 35.0 0.4 0.0016 18.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO46010.1 - 0.00026 20.3 6.6 0.091 12.3 0.7 2.7 2 0 0 2 2 2 2 EF hand Thioredoxin PF00085.20 KOO46010.1 - 0.0016 18.4 0.2 0.08 12.9 0.0 3.4 3 1 1 4 4 4 1 Thioredoxin DAG_kinase_N PF14513.6 KOO46010.1 - 0.15 12.2 9.1 0.56 10.4 9.1 1.9 1 1 0 1 1 1 0 Diacylglycerol kinase N-terminus HGD-D PF06050.13 KOO46010.1 - 0.32 10.7 5.5 0.63 9.7 5.5 1.4 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component DDHD PF02862.17 KOO46010.1 - 0.44 10.7 2.5 0.94 9.6 2.5 1.5 1 0 0 1 1 1 0 DDHD domain Borrelia_P83 PF05262.11 KOO46010.1 - 1 7.8 20.9 1.6 7.1 20.9 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein ALMT PF11744.8 KOO46010.1 - 1.1 8.0 8.1 1.7 7.4 8.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 KOO46010.1 - 7.5 4.5 9.2 11 4.0 9.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Arm PF00514.23 KOO46011.1 - 1.7e-30 104.1 1.0 3.2e-12 46.0 0.0 3.8 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KOO46011.1 - 3.4e-21 74.6 0.4 5.2e-21 74.0 0.4 1.2 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.6 KOO46011.1 - 0.00015 22.1 0.0 0.034 14.5 0.0 3.0 2 1 0 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 KOO46011.1 - 0.0037 17.7 0.0 2.3 8.8 0.0 2.6 2 0 0 2 2 2 2 HEAT-like repeat CTNNBL PF08216.11 KOO46011.1 - 0.058 13.6 0.0 9.4 6.5 0.0 2.9 3 0 0 3 3 3 0 Catenin-beta-like, Arm-motif containing nuclear V-ATPase_H_C PF11698.8 KOO46011.1 - 0.12 12.5 0.0 0.69 10.0 0.0 2.1 2 1 0 2 2 2 0 V-ATPase subunit H EF-hand_8 PF13833.6 KOO46710.1 - 0.00079 19.2 0.0 0.00096 19.0 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 KOO46710.1 - 0.0027 18.1 0.0 0.0032 17.9 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair ATPase PF06745.13 KOO46710.1 - 0.22 10.8 0.0 0.26 10.6 0.0 1.0 1 0 0 1 1 1 0 KaiC DUF5578 PF17741.1 KOO46730.1 - 6.7e-73 245.4 1.8 2.2e-72 243.7 0.6 2.1 2 1 0 2 2 2 1 Family of unknown function (DUF5578) Arm PF00514.23 KOO46730.1 - 0.14 12.2 4.4 11 6.3 0.2 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat TRAP_beta PF05753.14 KOO46732.1 - 2.4e-18 66.2 0.0 2.9e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) WD40 PF00400.32 KOO46733.1 - 1.9e-09 38.0 0.1 0.0073 17.1 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat PQQ_3 PF13570.6 KOO46733.1 - 0.11 13.0 8.2 1.1 9.8 0.6 3.4 3 0 0 3 3 3 0 PQQ-like domain HEAT_2 PF13646.6 KOO47051.1 - 9.3e-23 80.4 38.7 3.6e-08 33.7 3.6 6.7 3 1 4 8 8 7 7 HEAT repeats HEAT PF02985.22 KOO47051.1 - 5.9e-17 60.3 23.0 0.35 11.3 0.0 10.4 10 0 0 10 10 10 7 HEAT repeat HEAT_EZ PF13513.6 KOO47051.1 - 3.5e-08 33.8 35.4 0.015 15.8 1.2 9.5 9 1 1 10 10 10 6 HEAT-like repeat Cnd1 PF12717.7 KOO47051.1 - 4e-08 33.5 9.4 0.0059 16.7 0.4 5.6 1 1 7 8 8 8 6 non-SMC mitotic condensation complex subunit 1 ADPrib_exo_Tox PF03496.14 KOO47051.1 - 4.6e-07 29.4 0.0 1.7e-06 27.6 0.0 1.9 2 1 0 2 2 2 1 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO47051.1 - 1.6e-06 27.5 0.0 5.4e-06 25.9 0.0 1.7 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase Cohesin_HEAT PF12765.7 KOO47051.1 - 0.0001 22.5 53.2 0.012 15.9 0.5 9.1 9 0 0 9 9 9 5 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.20 KOO47051.1 - 0.0015 17.2 0.0 0.036 12.6 0.0 2.3 1 1 0 1 1 1 1 Adaptin N terminal region NSs PF11073.8 KOO47051.1 - 0.087 12.3 2.0 58 3.0 0.0 4.5 1 1 4 6 6 6 0 Rift valley fever virus non structural protein (NSs) like PEP-CTERM PF07589.11 KOO47051.1 - 0.43 10.7 11.3 2.5e+02 2.0 0.1 7.7 9 0 0 9 9 9 0 PEP-CTERM motif Arm PF00514.23 KOO47051.1 - 1.4 9.1 10.6 1.6e+02 2.6 0.0 7.3 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat Pox_Ag35 PF03286.14 KOO47052.1 - 0.0083 15.9 0.4 0.0083 15.9 0.4 1.6 2 0 0 2 2 2 1 Pox virus Ag35 surface protein DUF2201_N PF13203.6 KOO47052.1 - 0.064 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain SnoaL_2 PF12680.7 KOO47055.1 - 0.046 14.4 0.2 0.12 13.0 0.1 1.7 1 1 1 2 2 2 0 SnoaL-like domain Gate PF07670.14 KOO47055.1 - 0.08 13.2 0.0 0.17 12.1 0.0 1.6 1 1 1 2 2 2 0 Nucleoside recognition Glyco_hydro_18 PF00704.28 KOO47056.1 - 0.079 12.7 0.1 0.099 12.3 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 Ion_trans_2 PF07885.16 KOO47153.1 - 1.2e-20 73.2 10.6 4.2e-11 42.6 1.3 2.3 2 0 0 2 2 2 2 Ion channel EF-hand_1 PF00036.32 KOO47153.1 - 1.6e-13 49.2 7.3 4.8e-05 22.6 0.0 4.5 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 KOO47153.1 - 2.5e-13 48.8 0.4 0.00018 21.2 0.0 3.9 3 1 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KOO47153.1 - 4.2e-11 43.1 0.0 2.2e-07 31.2 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO47153.1 - 1.1e-08 34.2 8.5 0.00021 20.7 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO47153.1 - 2.3e-06 27.3 5.2 0.0096 15.7 0.0 3.1 3 1 1 4 4 4 2 EF-hand domain pair Ion_trans PF00520.31 KOO47153.1 - 0.0016 17.7 4.9 0.014 14.6 0.9 2.2 2 0 0 2 2 2 2 Ion transport protein MMR_HSR1 PF01926.23 KOO47155.1 - 3.4e-16 59.3 0.0 5.9e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOO47155.1 - 2.4e-06 27.2 0.0 3.9e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOO47155.1 - 3.6e-06 27.1 0.0 0.0099 15.9 0.2 2.2 2 0 0 2 2 2 2 Dynamin family GRIP PF01465.20 KOO47155.1 - 4.8e-06 26.4 0.0 9.2e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 GRIP domain RsgA_GTPase PF03193.16 KOO47155.1 - 0.00099 19.0 0.0 0.064 13.1 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase SRPRB PF09439.10 KOO47155.1 - 0.0035 16.8 0.0 0.0069 15.8 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 KOO47155.1 - 0.02 15.4 0.0 0.041 14.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter IIGP PF05049.13 KOO47155.1 - 0.02 14.0 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_21 PF13304.6 KOO47155.1 - 0.09 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Ank_4 PF13637.6 KOO47156.1 - 1.9e-23 82.5 1.7 5.6e-11 42.7 0.2 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO47156.1 - 1.8e-19 69.5 1.0 7.3e-14 51.7 0.4 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO47156.1 - 1.2e-17 64.3 0.2 2.5e-15 56.8 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO47156.1 - 1.8e-12 47.1 0.4 0.00013 22.3 0.1 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KOO47156.1 - 1.1e-11 43.8 0.1 0.00056 20.2 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat GLTP PF08718.11 KOO47172.1 - 6.4e-18 65.5 0.0 8.5e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) CaATP_NAI PF12515.8 KOO47172.1 - 0.018 14.6 0.1 0.063 12.9 0.0 1.9 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain Mating_N PF12731.7 KOO47172.1 - 0.16 12.0 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Mating-type protein beta 1 DnaJ PF00226.31 KOO47173.1 - 1e-15 57.6 0.1 1.7e-15 56.9 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.6 KOO47173.1 - 1e-14 54.5 0.1 2.7e-13 49.9 0.1 2.2 1 1 0 1 1 1 1 X-domain of DnaJ-containing PRIMA1 PF16101.5 KOO47176.1 - 0.12 12.4 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 TUDOR_5 PF18359.1 KOO47187.1 - 0.003 17.2 0.0 0.006 16.3 0.0 1.5 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 TonB_C PF03544.14 KOO47187.1 - 0.069 13.6 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 Gram-negative bacterial TonB protein C-terminal VCBS PF13517.6 KOO47441.1 - 8.4e-35 119.2 25.3 6.1e-15 55.6 5.7 3.2 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO47441.1 - 1.5e-18 66.6 38.2 0.00012 22.1 3.0 4.5 4 0 0 4 4 4 4 FG-GAP repeat TcdB_toxin_midN PF12256.8 KOO47441.1 - 1.2e-05 24.7 13.1 0.24 10.7 0.1 4.0 1 1 2 4 4 4 4 Insecticide toxin TcdB middle/N-terminal region Dockerin_1 PF00404.18 KOO47441.1 - 2.5e-05 24.3 5.5 4.6 7.5 0.1 4.3 4 0 0 4 4 4 3 Dockerin type I domain EF-hand_5 PF13202.6 KOO47441.1 - 0.0021 17.5 21.1 2.9 7.5 0.6 4.5 4 0 0 4 4 4 4 EF hand EF-hand_1 PF00036.32 KOO47441.1 - 0.0032 16.9 12.1 7.8 6.3 0.1 4.3 4 0 0 4 4 4 3 EF hand TM_PBP2_N PF16296.5 KOO47441.1 - 0.095 12.8 0.0 37 4.5 0.0 3.6 3 1 0 4 4 4 0 N-terminal of TM subunit in PBP-dependent ABC transporters DUF1150 PF06620.11 KOO47441.1 - 0.14 12.3 0.0 30 4.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1150) Asp-B-Hydro_N PF05279.11 KOO47441.1 - 0.28 11.2 17.2 13 5.8 0.3 4.1 4 0 0 4 4 4 0 Aspartyl beta-hydroxylase N-terminal region Itfg2 PF15907.5 KOO47441.1 - 0.47 9.5 4.7 36 3.2 0.1 3.7 4 0 0 4 4 4 0 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 KOO47441.1 - 1.8 8.6 4.4 66 3.6 0.0 3.6 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region LON_substr_bdg PF02190.16 KOO47443.1 - 3.3e-07 30.4 0.0 1e-05 25.6 0.0 2.2 2 0 0 2 2 2 2 ATP-dependent protease La (LON) substrate-binding domain PAE PF03283.13 KOO47707.1 - 2.4e-67 227.6 1.0 1.4e-66 225.1 0.0 2.0 2 0 0 2 2 2 1 Pectinacetylesterase Somatomedin_B PF01033.17 KOO47707.1 - 3.5e-06 27.3 15.6 3.5e-06 27.3 15.6 2.2 2 0 0 2 2 2 1 Somatomedin B domain Peptidase_S9 PF00326.21 KOO47707.1 - 0.019 14.4 0.1 0.042 13.3 0.1 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ank_2 PF12796.7 KOO47708.1 - 8.3e-15 55.2 0.6 3.9e-14 53.0 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO47708.1 - 1.3e-14 54.3 0.2 8.9e-06 26.2 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO47708.1 - 4.4e-14 52.4 6.0 1.2e-08 35.1 0.5 2.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO47708.1 - 1.4e-10 40.4 0.0 0.0028 18.0 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOO47708.1 - 1.4e-09 37.9 0.9 0.0057 17.0 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Pkinase PF00069.25 KOO47709.1 - 1.1e-45 156.1 0.0 1.6e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO47709.1 - 9.3e-39 133.3 0.0 1.7e-38 132.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO47709.1 - 0.00021 20.2 0.1 0.00048 19.0 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOO47709.1 - 0.0069 15.7 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO47709.1 - 0.19 11.1 0.0 0.36 10.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_6 PF13516.6 KOO47710.1 - 6e-28 94.5 13.1 1.6e-05 24.6 0.2 6.8 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 KOO47710.1 - 0.0056 17.1 2.5 7.7 7.1 0.3 4.5 3 1 3 6 6 6 2 Leucine Rich repeats (2 copies) Lipocalin_3 PF12702.7 KOO47710.1 - 0.16 12.1 0.1 22 5.2 0.0 3.2 1 1 3 4 4 4 0 Lipocalin-like SpoU_sub_bind PF08032.12 KOO47710.1 - 0.31 11.4 1.7 7.6 6.9 0.1 2.8 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding HHH_5 PF14520.6 KOO47710.1 - 0.71 10.5 5.0 4.6 7.9 0.0 4.0 4 1 0 4 4 4 0 Helix-hairpin-helix domain CbiG_N PF11760.8 KOO47710.1 - 0.73 9.9 14.4 12 5.9 0.1 5.2 5 1 0 5 5 5 0 Cobalamin synthesis G N-terminal Arm-DNA-bind_1 PF09003.10 KOO47710.1 - 4.5 7.5 14.7 12 6.1 0.1 4.7 2 1 3 5 5 5 0 Bacteriophage lambda integrase, Arm DNA-binding domain HOASN PF14515.6 KOO47710.1 - 10 6.6 12.8 41 4.7 0.3 4.9 2 1 4 6 6 6 0 Haem-oxygenase-associated N-terminal helices PI3_PI4_kinase PF00454.27 KOO48198.1 - 1.1e-48 166.2 0.5 7.6e-30 104.5 0.1 3.0 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KOO48198.1 - 9.2e-48 162.1 0.5 1.8e-47 161.1 0.5 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 KOO48198.1 - 2.3e-11 43.8 0.0 4.1e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 TRAM_LAG1_CLN8 PF03798.16 KOO48553.1 - 4.2e-09 36.4 22.3 5.2e-09 36.1 22.3 1.1 1 0 0 1 1 1 1 TLC domain ANTAR PF03861.14 KOO48554.1 - 0.031 14.1 0.3 0.087 12.7 0.3 1.7 1 0 0 1 1 1 0 ANTAR domain zf-RING_2 PF13639.6 KOO48555.1 - 3.6e-13 49.6 5.0 1.1e-12 48.1 5.0 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOO48555.1 - 1.4e-10 40.7 4.9 1.4e-10 40.7 4.9 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 KOO48555.1 - 2.1e-08 33.9 3.1 5.4e-08 32.6 3.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOO48555.1 - 3.3e-08 33.7 5.4 1.2e-07 31.9 5.4 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KOO48555.1 - 1e-06 28.5 5.9 5.2e-06 26.2 5.9 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO48555.1 - 7.9e-06 25.8 1.5 1.7e-05 24.7 0.6 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 KOO48555.1 - 0.0017 18.3 5.2 0.0025 17.8 3.0 2.4 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 KOO48555.1 - 0.0041 17.0 3.3 0.01 15.7 3.3 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 FANCL_C PF11793.8 KOO48555.1 - 0.0043 17.2 6.8 0.0048 17.0 4.4 2.3 2 1 0 2 2 2 1 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 KOO48555.1 - 0.0071 16.2 2.5 0.022 14.6 2.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO48555.1 - 0.02 14.8 3.5 0.02 14.8 3.5 1.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOO48555.1 - 0.04 14.1 3.4 0.04 14.1 3.4 2.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 KOO48555.1 - 0.046 13.4 3.0 0.13 11.9 3.0 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Malic_M PF03949.15 KOO48557.1 - 3.6e-83 278.8 0.1 4.6e-83 278.4 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 KOO48557.1 - 1.2e-66 224.0 0.0 2.5e-66 222.9 0.0 1.6 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain Pyr_redox_2 PF07992.14 KOO48557.1 - 0.001 18.4 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pro-rich PF15240.6 KOO48558.1 - 0.00039 20.7 32.2 0.00059 20.2 32.2 1.3 1 0 0 1 1 1 1 Proline-rich DUF1846 PF08903.11 KOO48558.1 - 0.27 9.7 0.0 0.38 9.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) ABC1 PF03109.16 KOO48643.1 - 1.4e-20 73.6 0.0 2.4e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 ABC1 family SCP2 PF02036.17 KOO48643.1 - 0.00066 20.1 0.0 0.0019 18.7 0.0 1.8 1 0 0 1 1 1 1 SCP-2 sterol transfer family PX PF00787.24 KOO48643.1 - 0.0068 16.4 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 PX domain SAP PF02037.27 KOO48644.1 - 7.7e-06 25.5 0.1 9.8e-06 25.2 0.1 1.1 1 0 0 1 1 1 1 SAP domain Cep57_CLD_2 PF14197.6 KOO48645.1 - 0.0083 16.2 14.1 0.21 11.7 12.2 3.1 1 1 1 2 2 2 2 Centrosome localisation domain of PPC89 Mod_r PF07200.13 KOO48645.1 - 0.046 13.8 6.9 0.27 11.4 1.7 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein VPS38 PF17649.1 KOO48645.1 - 0.068 12.0 1.1 0.084 11.7 1.1 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 38 Fez1 PF06818.15 KOO48645.1 - 0.075 13.5 9.4 0.12 12.9 9.4 1.3 1 0 0 1 1 1 0 Fez1 COG5 PF10392.9 KOO48645.1 - 0.083 13.1 7.3 0.95 9.6 1.6 2.4 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DUF4201 PF13870.6 KOO48645.1 - 0.17 11.6 11.4 0.29 10.9 11.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Mto2_bdg PF12808.7 KOO48645.1 - 0.22 11.9 12.2 0.51 10.7 0.1 3.9 2 1 2 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region UPF0242 PF06785.11 KOO48645.1 - 0.23 11.5 9.0 0.13 12.4 6.2 1.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ZapB PF06005.12 KOO48645.1 - 0.35 11.3 13.8 8.4 6.9 6.6 3.5 1 1 1 2 2 2 0 Cell division protein ZapB Csm1_N PF18504.1 KOO48645.1 - 0.42 11.0 10.6 1.4 9.3 0.5 2.6 2 1 1 3 3 2 0 Csm1 N-terminal domain ABC_tran_CTD PF16326.5 KOO48645.1 - 0.59 10.4 4.4 0.71 10.2 0.5 2.5 1 1 1 2 2 2 0 ABC transporter C-terminal domain NYD-SP28_assoc PF14775.6 KOO48645.1 - 0.82 9.8 3.2 36 4.6 0.1 3.1 2 1 1 3 3 3 0 Sperm tail C-terminal domain MCC-bdg_PDZ PF10506.9 KOO48645.1 - 0.84 9.7 5.8 42 4.2 0.4 3.4 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Vps51 PF08700.11 KOO48645.1 - 1.1 9.4 6.9 2.2 8.4 0.7 2.8 3 1 0 3 3 2 0 Vps51/Vps67 DUF16 PF01519.16 KOO48645.1 - 1.5 9.3 5.1 0.69 10.4 1.5 2.0 2 1 1 3 3 3 0 Protein of unknown function DUF16 Troponin PF00992.20 KOO48645.1 - 1.7 8.9 14.4 1 9.7 4.4 2.1 1 1 1 2 2 2 0 Troponin YabA PF06156.13 KOO48645.1 - 1.8 9.3 8.3 1.6e+02 3.0 8.3 2.8 1 1 0 1 1 1 0 Initiation control protein YabA TMCO5 PF14992.6 KOO48645.1 - 1.9 8.0 6.5 2.5 7.6 6.5 1.1 1 0 0 1 1 1 0 TMCO5 family Spc7 PF08317.11 KOO48645.1 - 2 7.2 11.1 5.2 5.9 11.1 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein FAM76 PF16046.5 KOO48645.1 - 2.5 7.4 8.7 0.16 11.3 2.6 1.8 1 1 1 2 2 2 0 FAM76 protein DUF4407 PF14362.6 KOO48645.1 - 2.6 7.3 13.1 16 4.8 13.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sec2p PF06428.11 KOO48645.1 - 3.4 7.7 10.0 2.4 8.2 0.1 2.8 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p DivIVA PF05103.13 KOO48645.1 - 5.4 7.1 12.4 0.22 11.6 5.2 1.9 1 1 1 2 2 2 0 DivIVA protein APG6_N PF17675.1 KOO48645.1 - 5.8 7.5 14.9 4.1 7.9 8.1 2.7 1 1 1 2 2 2 0 Apg6 coiled-coil region PIP5K PF01504.18 KOO48646.1 - 2.9e-53 180.9 0.0 3.6e-45 154.3 0.1 2.1 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase 7tm_1 PF00001.21 KOO48646.1 - 2.8e-06 26.8 14.9 6e-06 25.8 14.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KOO48646.1 - 0.8 9.0 16.1 9.9 5.5 16.1 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx FAT PF02259.23 KOO48647.1 - 0.2 10.8 0.0 0.27 10.4 0.0 1.1 1 0 0 1 1 1 0 FAT domain Kinesin PF00225.23 KOO48648.1 - 1.1e-61 208.7 0.0 1.9e-61 207.8 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO48648.1 - 8.4e-14 51.8 0.0 1.5e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding Sigma54_activat PF00158.26 KOO48648.1 - 0.0048 16.6 0.2 0.22 11.2 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 KOO48648.1 - 0.021 15.2 0.1 0.021 15.2 0.1 5.2 4 1 1 5 5 5 0 AAA ATPase domain DUF87 PF01935.17 KOO48648.1 - 4.4 7.3 10.1 0.51 10.4 0.1 3.1 4 0 0 4 4 4 0 Helicase HerA, central domain PDEase_I PF00233.19 KOO48649.1 - 2.5e-71 240.2 0.0 3.6e-71 239.6 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase LRR_6 PF13516.6 KOO48649.1 - 1.3e-33 112.2 0.4 3.4e-05 23.5 0.0 5.7 5 1 0 5 5 5 5 Leucine Rich repeat z-alpha PF02295.17 KOO48649.1 - 0.0011 19.0 3.0 0.0068 16.4 0.1 3.6 5 0 0 5 5 5 1 Adenosine deaminase z-alpha domain LRR_4 PF12799.7 KOO48649.1 - 0.0055 17.1 0.1 3.3 8.3 0.0 3.9 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) HD PF01966.22 KOO48649.1 - 0.11 12.7 0.3 0.47 10.7 0.1 2.2 2 0 0 2 2 2 0 HD domain FAM25 PF15825.5 KOO48649.1 - 2.4 8.6 17.0 2.1 8.8 0.1 5.3 4 1 1 5 5 5 0 FAM25 family tRNA-synt_His PF13393.6 KOO48649.1 - 3.9 6.7 7.9 0.99 8.6 3.1 2.3 2 1 1 3 3 3 0 Histidyl-tRNA synthetase CbiG_N PF11760.8 KOO48649.1 - 7.6 6.6 10.5 13 5.9 0.2 3.9 5 0 0 5 5 5 0 Cobalamin synthesis G N-terminal Pkinase_Tyr PF07714.17 KOO50193.1 - 1.9e-38 132.3 0.0 4.3e-38 131.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO50193.1 - 4.6e-38 131.1 0.0 9e-38 130.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Adeno_E3_CR2 PF02439.15 KOO50193.1 - 0.0002 21.0 3.6 0.00036 20.2 3.6 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 FTA2 PF13095.6 KOO50193.1 - 0.0036 17.0 0.0 0.34 10.5 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Protocadherin PF08374.11 KOO50193.1 - 0.0041 17.1 0.2 0.007 16.4 0.2 1.3 1 0 0 1 1 1 1 Protocadherin CRC_subunit PF08624.10 KOO50193.1 - 0.022 15.2 0.1 0.13 12.6 0.0 2.1 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit EphA2_TM PF14575.6 KOO50193.1 - 0.047 14.6 0.3 0.11 13.4 0.3 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 KOO50193.1 - 0.069 13.0 8.1 0.049 13.5 2.1 2.5 2 0 0 2 2 2 0 Rifin Stevor PF17410.2 KOO50193.1 - 0.076 12.5 3.9 3.7 7.0 1.0 2.4 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame Gram_pos_anchor PF00746.21 KOO50193.1 - 0.1 12.6 0.3 0.23 11.5 0.3 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Glycophorin_A PF01102.18 KOO50193.1 - 0.14 12.4 5.9 0.26 11.6 5.2 1.8 1 1 0 1 1 1 0 Glycophorin A Shisa PF13908.6 KOO50193.1 - 0.16 12.2 0.4 0.38 11.0 0.4 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Syndecan PF01034.20 KOO50193.1 - 0.18 11.8 1.5 0.37 10.8 1.5 1.5 1 0 0 1 1 1 0 Syndecan domain DUF2525 PF10733.9 KOO50193.1 - 0.37 11.1 1.3 0.89 9.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2525) SKG6 PF08693.10 KOO50193.1 - 0.43 10.0 5.1 1.1 8.8 5.1 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CorA PF01544.18 KOO50195.1 - 4.1e-18 65.7 0.0 5.3e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Cas1_AcylT PF07779.12 KOO50196.1 - 2.6e-82 277.3 14.3 3.6e-82 276.8 14.3 1.1 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p DUF3098 PF11297.8 KOO50196.1 - 0.03 13.9 0.1 0.11 12.1 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) CHAD PF05235.14 KOO50197.1 - 0.0049 16.9 0.9 0.0056 16.7 0.9 1.2 1 0 0 1 1 1 1 CHAD domain Arm PF00514.23 KOO50198.1 - 0.0014 18.6 0.2 0.0052 16.8 0.2 2.1 1 0 0 1 1 1 1 Armadillo/beta-catenin-like repeat Phage_holin_4_2 PF04020.13 KOO50199.1 - 1.7 9.4 20.1 2.2 9.0 3.6 3.5 1 1 3 4 4 4 0 Mycobacterial 4 TMS phage holin, superfamily IV MFS_1 PF07690.16 KOO50201.1 - 6.5e-12 45.0 15.5 8.5e-12 44.7 15.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily ATG22 PF11700.8 KOO50201.1 - 0.0053 15.4 1.6 0.055 12.1 0.2 2.1 2 0 0 2 2 2 2 Vacuole effluxer Atg22 like DUF1824 PF08854.10 KOO50201.1 - 0.12 12.3 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1824) Ion_trans PF00520.31 KOO50202.1 - 1.6e-168 558.0 53.3 1.5e-52 178.3 7.2 4.0 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KOO50202.1 - 1.7e-06 27.0 4.9 1.7e-06 27.0 4.9 8.8 8 2 1 10 10 10 6 Polycystin cation channel GPHH PF16905.5 KOO50202.1 - 8e-06 25.5 0.0 1.8e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated ketoacyl-synt PF00109.26 KOO50207.1 - 5.9e-50 170.2 5.4 1e-49 169.4 5.4 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOO50207.1 - 5.4e-23 81.2 2.9 1.1e-22 80.2 2.9 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 KOO50207.1 - 4e-12 46.3 0.3 1.1e-11 44.9 0.1 1.9 2 0 0 2 2 2 1 Phosphopantetheine attachment site NAD_binding_7 PF13241.6 KOO50207.1 - 0.095 13.1 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding RSN1_7TM PF02714.15 KOO50210.1 - 6.2e-24 84.7 6.3 6.2e-24 84.7 6.3 1.4 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 KOO50210.1 - 0.00027 21.2 0.0 0.00042 20.6 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF4774 PF15999.5 KOO50954.1 - 0.049 13.4 0.2 0.083 12.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4774) Kelch_6 PF13964.6 KOO52712.1 - 0.041 14.2 0.0 0.095 13.0 0.0 1.6 1 0 0 1 1 1 0 Kelch motif Chorein_N PF12624.7 KOO52729.1 - 4.7e-24 84.7 0.0 1.1e-23 83.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 KOO52729.1 - 1.4e-07 31.6 1.0 7.9e-05 22.6 0.0 2.5 2 0 0 2 2 2 2 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 KOO52730.1 - 1.8e-13 50.5 0.0 2.8e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 Ank_2 PF12796.7 KOO52730.1 - 1.5e-08 35.1 0.1 3.6e-08 33.9 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) PH PF00169.29 KOO52730.1 - 1.6e-08 35.0 0.0 3.3e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 PH domain Ank_4 PF13637.6 KOO52730.1 - 2.4e-06 27.9 0.2 5.4e-06 26.8 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO52730.1 - 0.00019 21.6 0.1 0.29 11.8 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KOO52730.1 - 0.00034 20.9 1.6 0.056 13.9 0.2 2.9 2 0 0 2 2 2 1 Ankyrin repeat GRAM PF02893.20 KOO52730.1 - 0.0004 20.3 0.0 0.86 9.5 0.0 2.3 2 0 0 2 2 2 2 GRAM domain Ank_5 PF13857.6 KOO52730.1 - 0.0052 17.1 0.2 0.75 10.2 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) PH_6 PF15406.6 KOO52730.1 - 0.025 14.9 0.1 0.2 11.9 0.0 2.6 3 0 0 3 3 3 0 Pleckstrin homology domain Pkinase PF00069.25 KOO52731.1 - 4.2e-39 134.5 0.0 5.7e-39 134.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO52731.1 - 2.2e-22 79.6 0.0 3.1e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ACT_4 PF13291.6 KOO52731.1 - 1.1e-05 25.9 0.1 2.7e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 ACT domain 3HCDH_N PF02737.18 KOO52732.1 - 5.4e-58 195.8 0.2 9e-58 195.1 0.2 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 KOO52732.1 - 1.3e-32 113.1 1.0 2.9e-32 112.0 1.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 KOO52732.1 - 6.3e-31 106.9 0.1 2.1e-25 89.2 0.1 2.8 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 KOO52732.1 - 6.7e-19 68.5 1.6 1.4e-18 67.5 1.6 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ApbA PF02558.16 KOO52732.1 - 0.0003 20.5 0.2 0.00057 19.5 0.2 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DAO PF01266.24 KOO52732.1 - 0.0011 18.7 0.2 0.0024 17.5 0.2 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 KOO52732.1 - 0.0022 17.6 0.1 0.004 16.7 0.1 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 KOO52732.1 - 0.0031 16.8 0.4 0.0048 16.2 0.4 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 KOO52732.1 - 0.0049 17.0 1.1 0.018 15.2 1.1 2.1 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 KOO52732.1 - 0.019 15.0 0.1 0.049 13.7 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 KOO52732.1 - 0.022 15.3 0.4 0.061 13.9 0.4 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 KOO52732.1 - 0.023 15.0 0.5 0.066 13.5 0.1 2.1 2 0 0 2 2 1 0 TrkA-N domain FAD_binding_3 PF01494.19 KOO52732.1 - 0.032 13.5 0.2 0.054 12.7 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain F420_oxidored PF03807.17 KOO52732.1 - 0.11 13.1 3.2 0.24 12.0 1.5 2.6 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent TPR_11 PF13414.6 KOO52733.1 - 1.2e-15 56.9 4.2 0.15 11.7 0.0 7.2 8 0 0 8 8 8 5 TPR repeat TPR_17 PF13431.6 KOO52733.1 - 1.8e-15 56.1 1.8 0.15 12.5 0.1 7.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO52733.1 - 1e-13 50.2 23.9 0.00029 20.7 0.1 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO52733.1 - 7.8e-12 45.0 34.3 0.0038 17.9 0.3 8.9 5 3 4 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOO52733.1 - 1.2e-08 35.1 25.3 0.24 11.7 4.5 5.7 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOO52733.1 - 1.3e-07 31.3 10.8 0.36 11.1 0.2 7.3 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO52733.1 - 3.5e-06 26.6 21.0 1.5 8.8 0.1 8.9 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO52733.1 - 1.2e-05 25.9 34.1 0.035 14.8 0.3 6.4 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO52733.1 - 1.3e-05 25.6 23.0 0.02 15.4 0.1 6.7 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOO52733.1 - 1.9e-05 24.7 19.0 9.3e-05 22.5 1.2 5.4 4 2 2 6 6 6 1 Tetratricopeptide repeat PUMA PF15826.5 KOO52733.1 - 0.077 13.2 0.0 0.077 13.2 0.0 3.0 4 0 0 4 4 3 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis ChAPs PF09295.10 KOO52733.1 - 0.22 10.5 0.1 1 8.3 0.0 2.1 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) SHNi-TPR PF10516.9 KOO52733.1 - 0.66 9.5 4.1 5.8 6.5 0.0 3.3 4 0 0 4 4 4 0 SHNi-TPR CD225 PF04505.12 KOO52733.1 - 1.5 9.0 3.6 8.9 6.5 0.1 2.5 2 0 0 2 2 2 0 Interferon-induced transmembrane protein Rbsn PF11464.8 KOO52733.1 - 3.2 7.5 5.5 1.4 8.7 0.6 2.7 2 1 0 2 2 2 0 Rabenosyn Rab binding domain TPR_7 PF13176.6 KOO52733.1 - 6.5 7.0 19.4 33 4.8 0.0 7.2 7 2 0 7 7 6 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 KOO52733.1 - 8.1 6.3 12.1 0.17 11.8 0.4 3.2 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal FlaF PF07309.11 KOO52733.1 - 9.3 6.3 8.6 2.3 8.2 3.5 2.4 3 0 0 3 3 3 0 Flagellar protein FlaF ketoacyl-synt PF00109.26 KOO52734.1 - 7.8e-35 120.7 1.0 9.5e-35 120.4 1.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOO52734.1 - 0.00034 20.6 0.1 0.045 13.8 0.0 2.9 3 0 0 3 3 3 2 Beta-ketoacyl synthase, C-terminal domain DNA_gyraseB PF00204.25 KOO52735.1 - 2.5e-47 160.6 0.0 7.6e-47 159.0 0.0 1.7 2 0 0 2 2 2 1 DNA gyrase B DNA_gyraseB_C PF00986.21 KOO52735.1 - 5.2e-24 84.2 0.2 1.1e-23 83.2 0.2 1.6 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus Toprim PF01751.22 KOO52735.1 - 6.7e-17 61.6 0.0 1.3e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 Toprim domain Tubulin PF00091.25 KOO52736.1 - 2.3e-66 223.7 0.0 2.8e-66 223.5 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOO52736.1 - 7.9e-05 22.8 0.1 0.00013 22.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KOO52736.1 - 0.0093 15.7 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain FAST_1 PF06743.15 KOO52737.1 - 6.2e-06 26.1 6.2 14 5.7 0.0 7.6 8 0 0 8 8 8 2 FAST kinase-like protein, subdomain 1 RAP PF08373.10 KOO52737.1 - 7.3e-05 22.8 0.0 0.00018 21.5 0.0 1.6 2 0 0 2 2 2 1 RAP domain U3snoRNP10 PF12397.8 KOO52737.1 - 8.7 6.7 15.0 7 7.0 0.2 4.8 4 0 0 4 4 4 0 U3 small nucleolar RNA-associated protein 10 SUI1 PF01253.22 KOO52738.1 - 2.3e-24 85.7 0.8 2.3e-24 85.7 0.8 1.5 2 0 0 2 2 2 1 Translation initiation factor SUI1 Spectrin PF00435.21 KOO52739.1 - 1.1e-09 38.8 3.6 0.00061 20.2 1.0 3.6 3 0 0 3 3 3 2 Spectrin repeat EF-hand_1 PF00036.32 KOO52739.1 - 1.3e-05 24.4 0.5 0.0028 17.1 0.1 2.9 2 0 0 2 2 2 2 EF hand EFhand_Ca_insen PF08726.10 KOO52739.1 - 0.00045 20.3 0.5 0.004 17.2 0.1 2.9 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_6 PF13405.6 KOO52739.1 - 0.0021 17.9 5.1 0.003 17.3 0.4 3.4 4 0 0 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 KOO52739.1 - 0.017 15.6 0.6 0.1 13.1 0.7 2.3 2 0 0 2 2 2 0 EF-hand domain pair FTO_CTD PF12934.7 KOO52739.1 - 0.054 13.3 0.7 0.32 10.7 0.0 2.4 2 0 0 2 2 2 0 FTO C-terminal domain Ribosom_S12_S23 PF00164.25 KOO52741.1 - 4.1e-50 168.2 0.3 5.4e-50 167.8 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Flavoprotein PF02441.19 KOO52742.1 - 5.5e-26 91.2 0.0 1e-25 90.3 0.0 1.4 1 0 0 1 1 1 1 Flavoprotein TPR_2 PF07719.17 KOO52742.1 - 2e-15 55.6 6.8 4.1e-06 26.5 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO52742.1 - 8.2e-15 53.9 6.2 4.7e-06 26.2 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat UPF0121 PF03661.13 KOO52742.1 - 9.7e-10 38.2 6.2 1.6e-09 37.5 6.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) TPR_8 PF13181.6 KOO52742.1 - 2.3e-07 30.5 1.8 0.0016 18.5 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO52742.1 - 1.3e-06 28.8 2.0 0.016 16.0 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO52742.1 - 1.3e-06 28.0 4.0 0.11 12.2 0.2 3.4 1 1 2 3 3 3 3 TPR repeat TPR_16 PF13432.6 KOO52742.1 - 0.00017 22.2 10.2 0.016 15.8 4.3 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO52742.1 - 0.0002 21.6 6.6 0.014 15.7 1.5 3.2 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO52742.1 - 0.00023 21.3 0.5 0.19 12.2 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO52742.1 - 0.0024 18.4 0.4 0.078 13.5 0.0 2.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO52742.1 - 0.027 14.5 0.7 2.7 8.2 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat VirionAssem_T7 PF11653.8 KOO52742.1 - 0.12 12.9 3.6 0.27 11.8 3.6 1.5 1 0 0 1 1 1 0 Bacteriophage T7 virion assembly protein TPR_6 PF13174.6 KOO52742.1 - 0.12 13.1 1.2 20 6.1 0.2 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat Hen1_L PF12623.7 KOO52744.1 - 0.019 14.0 1.0 0.025 13.6 1.0 1.3 1 0 0 1 1 1 0 RNA repair, ligase-Pnkp-associating, region of Hen1 MscS_porin PF12795.7 KOO52744.1 - 0.025 14.1 30.2 0.13 11.8 6.0 3.0 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain Cluap1 PF10234.9 KOO52744.1 - 0.081 12.3 7.1 0.12 11.7 7.1 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 GvpK PF05121.12 KOO52744.1 - 0.3 11.1 4.0 0.28 11.2 1.1 2.3 2 2 0 2 2 2 0 Gas vesicle protein K DUF3584 PF12128.8 KOO52744.1 - 0.75 7.2 12.2 0.98 6.9 12.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4404 PF14357.6 KOO52744.1 - 1.2 9.9 7.6 1.4 9.6 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) DUF4423 PF14394.6 KOO52744.1 - 1.2 8.9 5.2 0.79 9.4 1.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4423) DUF5339 PF17274.2 KOO52744.1 - 1.7 9.6 5.3 15 6.5 2.5 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5339) SHIPPO-rpt PF07004.12 KOO52745.1 - 2.5e-10 40.8 14.2 0.00086 20.1 0.4 4.4 3 1 0 3 3 3 3 Sperm-tail PG-rich repeat Rick_17kDa_Anti PF05433.15 KOO52745.1 - 0.18 11.7 8.9 0.4 10.6 8.9 1.5 1 0 0 1 1 1 0 Glycine zipper 2TM domain Bacteriocin_IIc PF10439.9 KOO52745.1 - 0.72 10.0 3.8 1.8 8.8 3.8 1.6 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_OmpA PF13436.6 KOO52745.1 - 2.4 8.0 11.3 1.9 8.3 9.3 1.8 2 0 0 2 2 2 0 Glycine-zipper domain Nucleotid_trans PF03407.16 KOO52746.1 - 1.7e-30 106.6 0.0 1.7e-29 103.4 0.0 2.2 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase HMG_box_2 PF09011.10 KOO52746.1 - 5e-06 27.0 0.1 1.4e-05 25.6 0.1 1.7 1 0 0 1 1 1 1 HMG-box domain CBFD_NFYB_HMF PF00808.23 KOO52746.1 - 0.00054 20.2 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HMG_box PF00505.19 KOO52746.1 - 0.00086 19.7 0.1 0.0019 18.6 0.1 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box NPA PF16469.5 KOO52746.1 - 0.0078 16.8 0.4 0.013 16.1 0.4 1.3 1 0 0 1 1 1 1 Nematode polyprotein allergen ABA-1 Histone PF00125.24 KOO52746.1 - 0.01 16.2 0.1 0.017 15.4 0.1 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KOO52746.1 - 0.011 15.9 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold BBIP10 PF14777.6 KOO52748.1 - 7.1e-24 83.2 0.3 8.6e-24 82.9 0.3 1.1 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 Ran_BP1 PF00638.18 KOO52749.1 - 0.00088 19.5 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 RanBP1 domain PCIF1_WW PF12237.8 KOO52750.1 - 4.3e-41 140.4 0.0 6.3e-40 136.6 0.0 2.1 2 0 0 2 2 2 1 Phosphorylated CTD interacting factor 1 WW domain HECT PF00632.25 KOO52751.1 - 7.2e-59 199.8 0.0 1e-58 199.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KOO52751.1 - 2.9e-10 40.0 0.1 5.4e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 WW domain Glyco_transf_90 PF05686.12 KOO52752.1 - 7.7e-38 130.4 0.0 1.9e-37 129.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 KOO52752.1 - 0.052 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 ABC_tran PF00005.27 KOO52753.1 - 2.1e-21 76.9 0.0 2.9e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 KOO52753.1 - 1.5e-14 53.9 23.3 3e-13 49.7 16.1 2.7 2 1 1 3 3 3 2 ABC-2 type transporter AAA_21 PF13304.6 KOO52753.1 - 9.6e-08 32.2 0.0 0.00056 19.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO52753.1 - 0.00018 21.1 0.3 0.015 14.8 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 KOO52753.1 - 0.0069 16.8 0.2 0.031 14.7 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KOO52753.1 - 0.016 15.1 0.1 0.025 14.5 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 KOO52753.1 - 0.037 14.3 0.4 0.083 13.2 0.4 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOO52753.1 - 0.066 13.6 0.1 0.11 12.8 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC2_membrane_3 PF12698.7 KOO52753.1 - 0.079 12.0 18.0 0.13 11.3 18.0 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein AAA_33 PF13671.6 KOO52753.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KOO52753.1 - 0.17 11.8 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain LMBR1 PF04791.16 KOO52753.1 - 0.19 10.6 9.6 0.026 13.4 4.0 2.0 1 1 1 2 2 2 0 LMBR1-like membrane protein AAA_23 PF13476.6 KOO52753.1 - 0.22 12.0 0.0 0.32 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 KOO52753.1 - 0.35 10.5 0.0 12 5.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Abhydrolase_1 PF00561.20 KOO52754.1 - 3.6e-20 72.7 0.1 3.8e-18 66.1 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOO52754.1 - 1.2e-16 62.0 3.3 1.2e-16 62.0 3.3 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO52754.1 - 4.8e-08 32.5 0.0 1.8e-07 30.6 0.1 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 US22 PF02393.16 KOO52754.1 - 0.016 15.5 0.0 0.03 14.6 0.0 1.5 1 0 0 1 1 1 0 US22 like Glyco_hydro_30 PF02055.16 KOO52755.1 - 6.6e-19 68.1 0.4 2.7e-09 36.5 0.0 2.3 2 1 0 2 2 2 2 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_cc PF11790.8 KOO52755.1 - 0.0052 16.4 0.0 0.0075 15.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_30C PF17189.4 KOO52755.1 - 0.028 14.6 0.1 0.08 13.2 0.1 1.8 1 1 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain p450 PF00067.22 KOO52757.1 - 5.3e-66 223.3 0.0 8.1e-66 222.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NIF PF03031.18 KOO52758.1 - 0.00014 21.7 0.0 0.00018 21.3 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SURNod19 PF07712.12 KOO52760.1 - 0.0013 17.6 0.1 1.1 7.9 0.0 2.2 2 0 0 2 2 2 2 Stress up-regulated Nod 19 LRR_6 PF13516.6 KOO52762.1 - 4.8e-09 35.5 0.8 0.073 13.2 0.0 4.5 4 0 0 4 4 4 3 Leucine Rich repeat TSC22 PF01166.18 KOO52763.1 - 1.3e-05 25.4 2.9 0.00063 20.0 0.8 2.6 2 0 0 2 2 2 1 TSC-22/dip/bun family YabA PF06156.13 KOO52763.1 - 0.02 15.5 5.3 0.21 12.2 5.3 2.3 1 1 0 1 1 1 0 Initiation control protein YabA HEAT PF02985.22 KOO52763.1 - 0.36 11.2 4.3 1.2 9.5 0.2 3.0 3 0 0 3 3 3 0 HEAT repeat DUF4407 PF14362.6 KOO52763.1 - 2.5 7.4 20.7 3.7 6.8 20.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GREB1 PF15782.5 KOO52763.1 - 3.2 4.7 5.6 3.9 4.4 5.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Arm PF00514.23 KOO52765.1 - 7.3e-46 152.9 12.3 6.4e-09 35.6 0.1 6.1 6 0 0 6 6 6 6 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO52765.1 - 0.00016 22.1 13.3 0.56 10.8 0.2 4.5 2 2 4 6 6 6 4 HEAT-like repeat Ig_mannosidase PF17753.1 KOO52765.1 - 0.00034 20.3 2.6 11 5.9 0.0 4.8 3 2 2 5 5 5 1 Ig-fold domain Acyl-CoA_dh_N PF02771.16 KOO52765.1 - 0.045 14.4 5.3 8.9 7.0 0.3 3.9 1 1 3 4 4 4 0 Acyl-CoA dehydrogenase, N-terminal domain Aconitase_B_N PF11791.8 KOO52765.1 - 0.071 13.2 4.6 2.4 8.2 0.4 3.2 2 1 1 3 3 3 0 Aconitate B N-terminal domain Arm_2 PF04826.13 KOO52765.1 - 0.13 11.6 0.0 5.8 6.3 0.0 2.4 1 1 2 3 3 3 0 Armadillo-like SpoVAC_SpoVAEB PF03862.13 KOO52765.1 - 0.3 11.4 3.5 2.8 8.2 0.0 3.4 1 1 3 4 4 4 0 SpoVAC/SpoVAEB sporulation membrane protein TPR_6 PF13174.6 KOO52765.1 - 0.59 10.9 7.7 36 5.3 0.0 4.6 5 1 1 6 6 6 0 Tetratricopeptide repeat CH PF00307.31 KOO52766.1 - 1.6e-71 237.4 1.3 1.6e-18 66.9 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.32 KOO52766.1 - 1e-12 46.6 0.3 4.5e-05 22.7 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO52766.1 - 1.1e-11 45.1 0.0 5.7e-11 42.7 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO52766.1 - 2e-10 40.4 0.1 4.3e-09 36.1 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO52766.1 - 4.2e-10 38.7 0.0 2.7e-05 23.8 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KOO52766.1 - 5.1e-09 35.2 0.1 0.00054 19.3 0.0 2.7 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.8 KOO52766.1 - 9e-09 35.1 0.0 0.0021 17.8 0.0 3.4 3 0 0 3 3 3 2 CAMSAP CH domain EF-hand_9 PF14658.6 KOO52766.1 - 0.05 13.9 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain Pkinase PF00069.25 KOO52767.1 - 1.1e-30 107.0 0.0 1.4e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO52767.1 - 5e-30 104.6 0.0 7.1e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TIR_2 PF13676.6 KOO52767.1 - 0.0042 17.7 0.0 0.0075 16.9 0.0 1.3 1 0 0 1 1 1 1 TIR domain Kinase-like PF14531.6 KOO52767.1 - 0.0087 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO52767.1 - 0.018 15.0 1.9 0.075 12.9 1.2 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO52767.1 - 0.18 11.1 0.4 0.28 10.5 0.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO52767.1 - 0.19 10.5 0.0 0.38 9.5 0.0 1.4 1 1 0 1 1 1 0 Fungal protein kinase PUB PF09409.10 KOO52768.1 - 9.3e-28 96.0 0.0 5.1e-16 58.4 0.0 2.2 2 0 0 2 2 2 2 PUB domain DUF1874 PF08960.10 KOO52768.1 - 0.027 14.6 0.0 7 6.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1874) Dicer_dimer PF03368.14 KOO52768.1 - 0.029 14.5 0.1 6.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Dicer dimerisation domain SIT PF15330.6 KOO52772.1 - 0.19 12.2 0.1 0.82 10.1 0.0 2.1 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT CcmH PF03918.14 KOO52772.1 - 2 7.7 6.8 3.4 6.9 0.3 3.2 2 1 1 3 3 3 0 Cytochrome C biogenesis protein EF-hand_1 PF00036.32 KOO52773.1 - 3.4e-12 45.0 0.0 1.8e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO52773.1 - 3.4e-10 40.2 0.0 4.9e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO52773.1 - 1.2e-09 37.3 0.2 0.00021 21.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO52773.1 - 1.1e-08 34.8 0.2 0.001 18.9 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO52773.1 - 4.2e-06 26.0 0.1 0.0011 18.4 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 KOO52773.1 - 0.0084 16.1 0.1 0.37 10.8 0.0 2.2 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF4241 PF14025.6 KOO52773.1 - 0.031 14.6 0.1 0.038 14.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4241) Ank_2 PF12796.7 KOO52774.1 - 8.5e-40 135.2 0.0 1.6e-10 41.4 0.0 8.2 5 3 3 8 8 8 7 Ankyrin repeats (3 copies) UCH PF00443.29 KOO52774.1 - 9.4e-23 81.0 0.0 1.5e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ank PF00023.30 KOO52774.1 - 1.4e-17 63.3 17.6 0.0078 16.6 0.2 11.0 12 0 0 12 12 12 4 Ankyrin repeat Ank_4 PF13637.6 KOO52774.1 - 1.3e-15 57.6 6.9 0.02 15.4 0.0 9.2 9 2 2 11 11 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO52774.1 - 1.1e-14 53.0 15.3 0.018 15.5 0.1 12.1 14 0 0 14 14 13 3 Ankyrin repeat Ank_5 PF13857.6 KOO52774.1 - 1.1e-10 41.5 8.1 0.057 13.7 0.1 7.5 7 2 1 8 8 7 3 Ankyrin repeats (many copies) zf-CCCH PF00642.24 KOO52774.1 - 1.2e-05 25.1 4.3 2.6e-05 24.0 4.3 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) KH_1 PF00013.29 KOO52774.1 - 2.8e-05 23.9 0.0 6.2e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 KH domain Torus PF16131.5 KOO52774.1 - 0.0018 18.9 0.1 0.0083 16.8 0.1 2.1 1 0 0 1 1 1 1 Torus domain DUF3563 PF12086.8 KOO52774.1 - 0.0024 17.5 0.4 0.0095 15.6 0.4 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3563) zf_CCCH_4 PF18345.1 KOO52774.1 - 0.012 15.7 3.6 0.025 14.6 3.6 1.6 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH_4 PF18044.1 KOO52774.1 - 0.54 10.1 4.0 1.2 9.0 4.0 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger Borrelia_P83 PF05262.11 KOO52774.1 - 7.6 4.9 21.8 12 4.2 21.8 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein IQ PF00612.27 KOO52775.1 - 0.00015 21.3 51.0 0.56 10.2 0.7 8.6 8 0 0 8 8 8 7 IQ calmodulin-binding motif Pro_CA PF00484.19 KOO52776.1 - 2.3e-55 187.2 1.9 1.5e-35 122.8 0.2 4.3 3 2 0 3 3 3 3 Carbonic anhydrase Pyr_redox_2 PF07992.14 KOO52778.1 - 3.8e-22 78.9 0.0 5.7e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AIRS_C PF02769.22 KOO52778.1 - 1.3e-20 74.1 1.3 2.4e-20 73.2 1.3 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 KOO52778.1 - 1.3e-14 54.6 0.6 4.9e-14 52.8 0.6 2.1 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain Pyr_redox PF00070.27 KOO52778.1 - 0.0012 19.3 0.1 0.0012 19.3 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO52778.1 - 0.17 11.1 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PDZ_3 PF17815.1 KOO52779.1 - 1.7e-20 73.4 0.0 3e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Trypsin_2 PF13365.6 KOO52779.1 - 1.1e-12 49.1 0.3 2.4e-12 48.0 0.3 1.7 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 KOO52779.1 - 0.00018 21.4 0.0 0.00039 20.3 0.0 1.5 1 0 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.9 KOO52779.1 - 0.0079 14.9 0.2 0.011 14.4 0.2 1.1 1 0 0 1 1 1 1 Peptidase S46 PDZ_6 PF17820.1 KOO52779.1 - 0.082 12.8 0.2 0.99 9.3 0.1 2.3 2 0 0 2 2 2 0 PDZ domain RRF PF01765.19 KOO52780.1 - 3e-56 189.9 0.5 4.2e-56 189.4 0.2 1.3 1 1 0 1 1 1 1 Ribosome recycling factor DUF104 PF01954.16 KOO52780.1 - 0.12 12.9 2.5 0.17 12.3 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF104 DUF2937 PF11157.8 KOO52780.1 - 0.2 11.4 0.1 0.37 10.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) YtxH PF12732.7 KOO52780.1 - 0.24 12.0 8.6 1.2 9.7 5.8 2.5 2 1 0 2 2 2 0 YtxH-like protein DUF883 PF05957.13 KOO52780.1 - 0.41 11.3 4.7 0.3 11.7 2.5 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) UCH PF00443.29 KOO52781.1 - 1.6e-22 80.3 0.0 1.9e-22 80.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOO52781.1 - 7.2e-10 39.0 0.0 1e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Med3 PF11593.8 KOO52781.1 - 7.6 5.6 8.3 11 5.0 8.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal UAA PF08449.11 KOO52782.1 - 1.3e-38 132.9 1.9 1.8e-38 132.5 1.9 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOO52782.1 - 2.4e-07 31.0 22.9 6.2e-05 23.2 9.1 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 KOO52782.1 - 0.0007 19.0 3.8 0.0045 16.4 3.8 2.0 1 1 0 1 1 1 1 Triose-phosphate Transporter family CRT-like PF08627.10 KOO52782.1 - 0.053 12.5 0.7 0.24 10.3 0.2 1.9 1 1 1 2 2 2 0 CRT-like, chloroquine-resistance transporter-like DUF1195 PF06708.11 KOO52782.1 - 0.06 13.1 0.2 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) Fer4 PF00037.27 KOO52783.1 - 1.7e-14 52.9 15.9 1.5e-08 34.1 4.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 KOO52783.1 - 8e-13 48.8 10.1 1.2e-12 48.2 10.1 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 KOO52783.1 - 6.9e-10 38.9 20.1 2.3e-07 30.8 11.4 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 KOO52783.1 - 9.6e-10 39.3 6.1 0.00021 22.2 0.2 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 KOO52783.1 - 5.1e-09 36.1 31.9 9.9e-06 25.6 12.3 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_9 PF13187.6 KOO52783.1 - 6.8e-09 35.8 10.2 1.1e-08 35.1 10.2 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 KOO52783.1 - 5.1e-07 29.5 17.4 0.00038 20.4 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 KOO52783.1 - 2.5e-06 27.9 19.2 0.00024 21.5 11.2 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 KOO52783.1 - 1.1e-05 25.5 11.0 0.00028 21.1 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 KOO52783.1 - 1.5e-05 24.8 12.1 0.011 15.8 3.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 KOO52783.1 - 0.00082 19.9 11.1 0.068 13.7 11.9 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 KOO52783.1 - 0.01 16.4 13.5 0.38 11.3 3.6 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I c-SKI_SMAD_bind PF08782.10 KOO52783.1 - 0.022 15.0 5.6 0.79 10.0 0.4 2.3 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_18 PF13746.6 KOO52783.1 - 0.036 14.3 8.5 0.8 9.9 1.3 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 KOO52783.1 - 0.044 14.7 16.1 0.077 14.0 3.8 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 KOO52783.1 - 0.2 11.8 6.1 2.7 8.2 0.9 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 KOO52783.1 - 0.37 11.6 11.3 1.7 9.6 1.6 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain EF-hand_1 PF00036.32 KOO52784.1 - 1.9e-11 42.6 0.0 0.00015 21.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO52784.1 - 6.1e-10 38.2 0.0 0.00021 21.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO52784.1 - 2.5e-07 31.0 0.0 6.1e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO52784.1 - 4.9e-07 29.0 0.0 0.0056 16.1 0.0 2.5 2 0 0 2 2 2 2 EF hand Pkinase PF00069.25 KOO52786.1 - 7.3e-56 189.4 0.2 1.1e-55 188.8 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO52786.1 - 1e-41 142.9 0.1 1.5e-41 142.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO52786.1 - 0.0002 20.3 0.0 0.00036 19.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOO52786.1 - 0.022 14.7 0.1 0.24 11.3 0.0 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO52786.1 - 0.041 13.2 0.1 0.081 12.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sugar_tr PF00083.24 KOO52787.1 - 1.1e-13 50.9 17.2 8.6e-12 44.7 11.7 3.0 3 0 0 3 3 3 3 Sugar (and other) transporter MFS_1 PF07690.16 KOO52787.1 - 3e-06 26.4 16.9 0.0011 18.0 9.5 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily Neurensin PF14927.6 KOO52787.1 - 0.23 11.2 2.9 1.1 9.0 0.2 2.9 3 0 0 3 3 3 0 Neurensin SHIPPO-rpt PF07004.12 KOO52789.1 - 3.4e-13 49.8 28.6 0.76 10.8 0.1 10.1 9 2 0 9 9 9 8 Sperm-tail PG-rich repeat Mobilization_B PF17511.2 KOO52790.1 - 0.13 12.7 0.7 0.42 11.0 0.7 1.9 1 0 0 1 1 1 0 Mobilization protein B WW PF00397.26 KOO52791.1 - 7.3e-10 38.8 3.9 1.5e-09 37.8 3.9 1.5 1 0 0 1 1 1 1 WW domain Fer4_13 PF13370.6 KOO52791.1 - 0.0016 18.9 0.1 0.0016 18.9 0.1 2.2 2 0 0 2 2 2 1 4Fe-4S single cluster domain of Ferredoxin I DAZAP2 PF11029.8 KOO52791.1 - 0.028 15.4 0.1 0.05 14.5 0.1 1.5 1 0 0 1 1 1 0 DAZ associated protein 2 (DAZAP2) MbtH PF03621.13 KOO52791.1 - 0.072 12.5 1.0 0.17 11.4 0.2 2.0 2 0 0 2 2 2 0 MbtH-like protein Peptidase_M32 PF02074.15 KOO52791.1 - 0.087 11.6 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase MtrC PF04211.13 KOO52792.1 - 0.02 13.9 7.3 0.024 13.7 7.3 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit C MscL PF01741.18 KOO52792.1 - 0.034 14.5 2.3 0.037 14.3 2.3 1.2 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL PHO4 PF01384.20 KOO52792.1 - 0.074 12.1 3.4 0.077 12.0 3.4 1.1 1 0 0 1 1 1 0 Phosphate transporter family DUF2953 PF11167.8 KOO52792.1 - 1.1 9.3 8.0 82 3.4 8.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2953) Clostridium_P47 PF06597.11 KOO52792.1 - 2.8 6.6 9.0 3.2 6.4 9.0 1.1 1 0 0 1 1 1 0 Clostridium P-47 protein DUF4231 PF14015.6 KOO52792.1 - 3.1 8.3 6.6 3.6 8.1 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) FKBP_C PF00254.28 KOO52793.1 - 5.4e-06 26.6 0.0 1.4e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase HHA PF05321.11 KOO52793.1 - 0.071 13.4 0.2 0.14 12.5 0.2 1.4 1 0 0 1 1 1 0 Haemolysin expression modulating protein LRR_8 PF13855.6 KOO52794.1 - 1.3e-06 28.1 0.4 2.6e-06 27.1 0.1 1.7 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 KOO52794.1 - 7.2e-05 23.1 0.0 0.0002 21.7 0.0 1.8 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO52794.1 - 0.076 13.6 0.6 0.54 11.0 0.0 2.7 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 KOO52794.1 - 0.078 13.1 0.0 0.59 10.3 0.0 2.6 2 0 0 2 2 2 0 Leucine Rich repeat Dpy-30 PF05186.13 KOO52796.1 - 0.05 13.3 0.1 0.27 11.0 0.0 2.2 3 0 0 3 3 3 0 Dpy-30 motif EF-hand_6 PF13405.6 KOO52798.1 - 5e-19 66.5 0.3 0.0014 18.4 0.0 6.0 6 0 0 6 6 6 4 EF-hand domain EF-hand_1 PF00036.32 KOO52798.1 - 3.7e-18 63.6 0.0 0.0023 17.3 0.1 4.8 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO52798.1 - 2.1e-17 63.3 0.0 1.5e-07 31.8 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO52798.1 - 2.2e-14 52.2 1.3 0.021 14.3 0.0 4.8 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO52798.1 - 9.4e-12 44.6 0.0 6.6e-05 22.7 0.0 4.8 4 1 1 5 5 5 2 EF-hand domain pair Ank_2 PF12796.7 KOO52798.1 - 1.5e-05 25.5 0.3 5.5e-05 23.7 0.3 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO52798.1 - 0.0049 17.4 0.6 0.15 12.7 0.2 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) EF-hand_9 PF14658.6 KOO52798.1 - 0.033 14.5 0.0 0.37 11.1 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 KOO52798.1 - 0.072 13.0 0.0 12 5.9 0.0 2.6 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Cep57_MT_bd PF06657.13 KOO52798.1 - 0.11 13.0 2.5 3.3 8.2 0.1 3.1 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 EF-hand_14 PF17959.1 KOO52798.1 - 0.18 12.2 0.0 0.73 10.2 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain EF-hand_10 PF14788.6 KOO52798.1 - 0.22 11.4 0.0 12 5.8 0.0 3.0 3 0 0 3 3 3 0 EF hand ArfGap PF01412.18 KOO52799.1 - 0.00092 19.3 0.0 0.002 18.2 0.0 1.6 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SpoVS PF04232.12 KOO52800.1 - 3.9e-38 129.1 3.2 1.2e-20 73.0 1.8 2.1 2 0 0 2 2 2 2 Stage V sporulation protein S (SpoVS) Pkinase PF00069.25 KOO52801.1 - 8.6e-31 107.3 0.0 1.3e-30 106.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO52801.1 - 5e-24 85.0 0.0 6.5e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PP2C PF00481.21 KOO52801.1 - 9.3e-24 84.4 0.0 1.5e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO52801.1 - 8.9e-06 25.5 0.3 2.4e-05 24.1 0.3 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOO52801.1 - 9.6e-05 22.4 0.3 0.001 19.0 0.3 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) APH PF01636.23 KOO52801.1 - 0.031 14.2 0.1 0.062 13.2 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Na_H_Exchanger PF00999.21 KOO52802.1 - 1.3e-49 169.0 25.2 1.7e-49 168.7 25.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Rad51 PF08423.11 KOO52803.1 - 3e-38 131.6 0.0 3.8e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KOO52803.1 - 4.3e-08 33.0 0.2 7.7e-08 32.1 0.2 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 KOO52803.1 - 5.1e-08 32.6 0.2 3.8e-06 26.4 0.2 2.3 2 1 0 2 2 2 1 KaiC RecA PF00154.21 KOO52803.1 - 7.5e-06 25.6 0.7 0.016 14.7 0.2 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein DnaB_C PF03796.15 KOO52803.1 - 1.2e-05 24.8 0.5 0.00021 20.7 0.5 2.0 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 KOO52803.1 - 0.028 14.7 0.1 0.054 13.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOO52803.1 - 0.033 13.4 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 KOO52803.1 - 0.037 14.4 0.6 0.07 13.5 0.6 1.5 1 1 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 KOO52803.1 - 0.037 13.5 0.2 0.066 12.7 0.2 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 KOO52803.1 - 0.11 12.2 0.0 0.59 9.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOO52803.1 - 0.18 12.3 0.0 0.3 11.6 0.0 1.3 1 1 0 1 1 1 0 ABC transporter TolA_bind_tri PF16331.5 KOO52804.1 - 2.1e-05 24.5 4.0 2.1e-05 24.5 4.0 10.2 7 3 3 10 10 10 1 TolA binding protein trimerisation BST2 PF16716.5 KOO52804.1 - 0.004 17.7 7.6 0.004 17.7 7.6 10.5 5 3 4 10 10 10 2 Bone marrow stromal antigen 2 FOXP-CC PF16159.5 KOO52804.1 - 0.25 12.0 0.2 0.25 12.0 0.2 7.6 5 2 4 9 9 9 0 FOXP coiled-coil domain HC2 PF07382.11 KOO52805.1 - 0.021 14.9 35.7 0.028 14.5 35.7 1.1 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Bud13 PF09736.9 KOO52805.1 - 3.7 7.9 9.4 5.2 7.4 9.4 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Asp-B-Hydro_N PF05279.11 KOO52805.1 - 3.9 7.5 11.0 5.3 7.0 11.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region JAB PF01398.21 KOO52808.1 - 2.7e-11 43.5 0.0 4.3e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 KOO52808.1 - 1.4e-08 34.5 0.1 3.1e-08 33.4 0.1 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain CCD48 PF15799.5 KOO52808.1 - 0.54 8.5 7.6 0.79 8.0 7.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 LRR_6 PF13516.6 KOO52809.1 - 2.6e-18 64.4 4.1 0.0003 20.6 0.1 4.6 4 0 0 4 4 4 4 Leucine Rich repeat NPR1_interact PF15699.5 KOO52809.1 - 0.073 13.7 0.7 14 6.4 0.1 2.2 2 0 0 2 2 2 0 NPR1 interacting Arm-DNA-bind_1 PF09003.10 KOO52809.1 - 0.48 10.6 5.7 34 4.7 0.1 3.8 3 1 1 4 4 4 0 Bacteriophage lambda integrase, Arm DNA-binding domain FAM25 PF15825.5 KOO52809.1 - 0.63 10.4 3.1 53 4.3 0.1 3.3 3 0 0 3 3 3 0 FAM25 family MFS_1 PF07690.16 KOO52811.1 - 3.9e-19 68.8 6.8 6.9e-19 68.0 6.8 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.13 KOO52811.1 - 0.00022 19.8 1.5 0.00022 19.8 1.5 1.5 2 0 0 2 2 2 1 Transmembrane secretion effector MFS_4 PF06779.14 KOO52811.1 - 0.00032 20.1 3.3 0.00046 19.6 3.3 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 KOO52811.1 - 0.0031 16.4 2.5 0.035 13.0 3.3 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 KOO52811.1 - 1.6 7.5 4.4 0.75 8.6 0.9 1.8 1 1 1 2 2 2 0 MFS_1 like family Homeodomain PF00046.29 KOO52812.1 - 0.00043 20.1 1.9 0.001 18.8 1.9 1.7 1 1 0 1 1 1 1 Homeodomain Ribosomal_S16 PF00886.19 KOO52812.1 - 0.068 13.2 0.0 0.14 12.2 0.0 1.5 1 1 0 1 1 1 0 Ribosomal protein S16 FA_hydroxylase PF04116.13 KOO52813.1 - 7.7e-14 52.2 8.4 1.4e-13 51.4 8.4 1.4 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily INCENP_ARK-bind PF03941.15 KOO52814.1 - 0.0061 16.5 0.7 0.018 15.0 0.2 2.0 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region DUF148 PF02520.17 KOO52814.1 - 0.062 13.4 1.1 0.15 12.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF148 DnaJ PF00226.31 KOO52814.1 - 0.075 13.2 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 DnaJ domain HHH_9 PF17674.1 KOO52814.1 - 0.096 13.6 0.2 30 5.6 0.0 2.9 1 1 0 2 2 2 0 HHH domain DUF808 PF05661.12 KOO52814.1 - 1.9 7.5 4.0 3 6.8 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF808) Kinesin PF00225.23 KOO52815.1 - 1.2e-41 142.8 0.1 1.7e-41 142.3 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Kinesin PF00225.23 KOO52816.1 - 3.7e-28 98.4 0.0 4.4e-28 98.2 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO52816.1 - 8.9e-14 51.7 0.0 8.4e-11 42.0 0.0 2.1 2 0 0 2 2 2 2 Microtubule binding T2SSE PF00437.20 KOO52816.1 - 0.15 11.1 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein G-7-MTase PF12803.7 KOO52817.1 - 0.087 12.0 0.0 2.1 7.5 0.0 2.1 1 1 1 2 2 2 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) Peptidase_M20 PF01546.28 KOO52818.1 - 6.7e-30 104.3 0.0 1e-29 103.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOO52818.1 - 1.7e-11 44.0 0.0 3.3e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KOO52818.1 - 0.00016 21.4 0.0 0.0019 17.9 0.0 2.3 2 0 0 2 2 2 1 Peptidase family M28 GspL_C PF12693.7 KOO52818.1 - 0.0048 16.8 0.2 0.011 15.6 0.2 1.6 1 0 0 1 1 1 1 GspL periplasmic domain GTP_EFTU PF00009.27 KOO52819.1 - 1.1e-05 25.1 0.0 1.9e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_28 PF13521.6 KOO52819.1 - 0.054 13.7 0.1 0.13 12.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KOO52819.1 - 0.061 13.8 0.0 0.089 13.3 0.0 1.4 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 KOO52819.1 - 0.069 13.2 0.1 0.14 12.3 0.1 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AlbA_2 PF04326.14 KOO52819.1 - 0.099 13.0 0.0 0.16 12.3 0.0 1.4 1 1 0 1 1 1 0 Putative DNA-binding domain Virul_Fac PF10139.9 KOO52819.1 - 0.28 9.4 0.1 0.38 8.9 0.1 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor FSH1 PF03959.13 KOO52821.1 - 2e-12 47.2 0.1 1.4e-10 41.2 0.1 2.1 1 1 0 1 1 1 1 Serine hydrolase (FSH1) cNMP_binding PF00027.29 KOO52822.1 - 1.9e-19 69.5 0.0 2.5e-10 40.3 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PASTA PF03793.19 KOO52823.1 - 0.11 12.4 1.4 0.43 10.5 0.1 2.1 2 0 0 2 2 2 0 PASTA domain TPR_9 PF13371.6 KOO52824.1 - 6.8e-08 32.6 3.7 6.8e-08 32.6 3.7 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO52824.1 - 1.2e-06 28.2 1.8 0.0009 19.2 0.7 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO52824.1 - 1.2e-05 24.9 1.5 0.0042 16.7 0.3 2.8 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.28 KOO52824.1 - 5.1e-05 22.9 0.6 0.00022 20.9 0.3 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO52824.1 - 0.007 16.6 4.0 0.026 14.8 0.3 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO52824.1 - 0.0078 16.8 4.9 0.012 16.2 0.6 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO52824.1 - 0.085 12.8 1.8 0.26 11.2 1.8 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO52824.1 - 2.9 9.0 10.6 36 5.5 4.8 4.1 2 1 1 3 3 3 0 Tetratricopeptide repeat Syntaxin-6_N PF09177.11 KOO52826.1 - 1.4e-15 57.6 0.8 1.4e-15 57.6 0.8 2.2 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 KOO52826.1 - 1.6e-05 24.8 0.1 3.8e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 SNARE domain Sec20 PF03908.13 KOO52826.1 - 0.00075 19.4 0.5 0.0022 17.8 0.2 1.9 1 1 0 1 1 1 1 Sec20 ETRAMP PF09716.10 KOO52826.1 - 0.04 14.0 0.0 0.068 13.2 0.0 1.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3450 PF11932.8 KOO52826.1 - 0.17 11.2 11.1 0.081 12.2 6.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) KLRAQ PF10205.9 KOO52826.1 - 0.32 11.2 6.8 0.7 10.2 2.6 2.5 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF16 PF01519.16 KOO52826.1 - 3.6 8.1 8.3 1.7 9.1 3.9 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF4407 PF14362.6 KOO52826.1 - 6.2 6.1 12.8 39 3.4 12.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 KOO52826.1 - 7.9 6.5 8.8 7.7 6.6 3.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 KOO52826.1 - 9.8 4.9 9.4 19 4.0 0.2 2.1 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF1682 PF07946.14 KOO52827.1 - 0.064 12.5 0.1 0.064 12.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Ribosomal_L35p PF01632.19 KOO52829.1 - 0.00042 20.7 7.4 0.00042 20.7 7.4 1.7 2 0 0 2 2 2 1 Ribosomal protein L35 Peptidase_C2 PF00648.21 KOO52830.1 - 3.2e-31 108.5 0.0 5.1e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease IQ PF00612.27 KOO52830.1 - 0.0078 15.9 0.8 1.3 9.0 0.1 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif Chloroplast_duf PF14476.6 KOO52831.1 - 0.027 13.5 0.9 0.038 13.0 0.9 1.1 1 0 0 1 1 1 0 Petal formation-expressed Methyltransf_21 PF05050.12 KOO52832.1 - 7.4e-07 29.3 0.0 1.4e-06 28.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase FkbM domain CBP_BcsQ PF06564.12 KOO52832.1 - 0.13 11.8 0.0 0.66 9.4 0.0 1.9 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ Peptidase_S10 PF00450.22 KOO52833.1 - 2e-38 132.9 0.0 8.2e-36 124.3 0.0 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase CAF1 PF04857.20 KOO52834.1 - 1.5e-15 57.2 0.5 2.9e-07 30.0 0.0 2.6 2 1 0 2 2 2 2 CAF1 family ribonuclease Rubis-subs-bind PF09273.11 KOO52835.1 - 6.8e-06 26.8 0.0 1.2e-05 26.0 0.0 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding NAD_binding_1 PF00175.21 KOO52836.1 - 0.076 13.7 1.7 0.26 11.9 0.4 1.9 1 1 1 2 2 2 0 Oxidoreductase NAD-binding domain WD40 PF00400.32 KOO52837.1 - 2e-37 126.5 11.0 0.0017 19.2 0.0 12.5 12 0 0 12 12 12 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO52837.1 - 4.9e-11 42.8 3.7 8.7e-05 22.7 0.0 7.0 5 2 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_7 PF13499.6 KOO52837.1 - 8.1e-10 39.0 0.3 2.2e-09 37.6 0.3 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO52837.1 - 4.5e-09 35.2 0.9 0.0012 18.2 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO52837.1 - 4.9e-09 35.9 2.6 2.9e-06 27.0 0.5 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO52837.1 - 9.4e-08 31.4 1.3 0.0078 16.1 0.2 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO52837.1 - 9.7e-08 31.2 1.3 0.00027 20.3 0.1 2.6 2 0 0 2 2 2 2 EF hand Nup160 PF11715.8 KOO52837.1 - 2.1e-06 26.7 3.3 0.25 10.0 0.1 5.0 4 1 0 5 5 5 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 KOO52837.1 - 0.0002 21.0 2.3 0.0064 16.1 0.1 3.4 2 1 1 3 3 3 1 PQQ-like domain Nucleoporin_N PF08801.11 KOO52837.1 - 0.00026 19.9 0.3 1.4 7.6 0.0 4.3 3 2 2 5 5 5 2 Nup133 N terminal like EF-hand_4 PF12763.7 KOO52837.1 - 0.00094 19.1 0.5 4.6 7.2 0.2 3.4 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand PALB2_WD40 PF16756.5 KOO52837.1 - 0.14 11.0 0.7 7.7 5.3 0.0 3.6 3 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Phage_integrase PF00589.22 KOO52838.1 - 0.00025 20.9 0.0 0.00042 20.1 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family Ank_2 PF12796.7 KOO52839.1 - 2.6e-27 95.2 1.1 1.7e-11 44.5 0.1 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO52839.1 - 2.3e-18 66.3 1.9 1.4e-08 35.1 0.3 3.4 2 1 2 4 4 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO52839.1 - 4.7e-13 49.1 0.3 1.9e-09 37.6 0.1 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO52839.1 - 4.6e-10 39.5 0.1 0.00042 20.6 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOO52839.1 - 2.1e-07 30.7 0.0 0.0016 18.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat HC2 PF07382.11 KOO52839.1 - 3.3e-05 24.0 20.7 3.3e-05 24.0 20.7 2.0 2 1 0 2 2 2 1 Histone H1-like nucleoprotein HC2 PT PF04886.12 KOO52839.1 - 0.046 13.3 9.7 0.11 12.1 9.7 1.5 1 0 0 1 1 1 0 PT repeat NifQ PF04891.12 KOO52839.1 - 1.7 9.0 8.2 1.1 9.5 4.9 2.0 1 1 1 2 2 2 0 NifQ CDC73_N PF16050.5 KOO52839.1 - 2.4 7.4 8.1 4.2 6.6 8.1 1.5 1 0 0 1 1 1 0 Paf1 complex subunit CDC73 N-terminal CENP-H PF05837.12 KOO52839.1 - 3.3 8.2 9.7 13 6.3 9.3 2.3 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Hc1 PF07432.13 KOO52839.1 - 6.9 7.1 26.6 0.035 14.5 17.0 2.1 2 0 0 2 2 2 0 Histone H1-like protein Hc1 Activator-TraM PF11657.8 KOO52841.1 - 0.027 14.3 3.2 0.033 14.0 3.2 1.2 1 0 0 1 1 1 0 Transcriptional activator TraM D5_N PF08706.11 KOO52841.1 - 0.12 12.7 1.5 0.14 12.5 1.5 1.1 1 0 0 1 1 1 0 D5 N terminal like CCDC-167 PF15188.6 KOO52842.1 - 0.0023 18.2 5.4 0.0027 18.0 5.4 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 PKcGMP_CC PF16808.5 KOO52842.1 - 0.0053 16.6 3.1 0.0053 16.6 3.1 1.7 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Kelch_1 PF01344.25 KOO52845.1 - 9.6e-26 89.1 3.1 6.5e-13 48.0 0.1 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 KOO52845.1 - 1.6e-18 66.2 0.0 1.2e-07 31.7 0.0 3.6 2 1 1 3 3 3 3 Kelch motif BACK PF07707.15 KOO52845.1 - 1e-16 60.9 0.1 1.6e-16 60.3 0.1 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 KOO52845.1 - 4.7e-14 52.6 0.0 1.1e-13 51.4 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KOO52845.1 - 3.9e-13 48.8 0.0 5.8e-05 22.9 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KOO52845.1 - 2.9e-12 46.6 1.7 6.6e-05 23.1 0.0 3.7 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO52845.1 - 5.6e-09 35.9 0.0 0.013 15.5 0.0 3.6 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO52845.1 - 0.019 15.0 0.1 0.16 12.0 0.1 2.5 2 0 0 2 2 2 0 Kelch motif MerR-DNA-bind PF09278.11 KOO52846.1 - 0.034 14.7 25.3 0.08 13.5 6.6 3.5 3 0 0 3 3 3 0 MerR, DNA binding Bcr-Abl_Oligo PF09036.10 KOO52846.1 - 0.065 13.2 5.2 2.8 8.0 0.5 3.1 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain SlyX PF04102.12 KOO52846.1 - 0.15 12.7 20.6 0.91 10.2 2.0 3.4 3 0 0 3 3 3 0 SlyX FAM76 PF16046.5 KOO52846.1 - 0.16 11.3 13.1 0.045 13.1 5.4 2.1 1 1 1 2 2 2 0 FAM76 protein Kinesin_assoc PF16183.5 KOO52846.1 - 1 9.5 13.1 0.068 13.3 5.1 2.1 1 1 1 2 2 2 0 Kinesin-associated XhlA PF10779.9 KOO52846.1 - 1.1 9.5 8.9 1.4 9.2 0.8 3.0 3 0 0 3 3 3 0 Haemolysin XhlA Rit1_C PF17184.4 KOO52846.1 - 2 7.8 7.8 1.5 8.2 0.7 2.2 1 1 1 2 2 2 0 Rit1 N-terminal domain LapA_dom PF06305.11 KOO52846.1 - 3.9 7.4 7.0 4.9 7.1 0.0 3.0 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Fic PF02661.18 KOO52846.1 - 7.3 7.6 6.1 2.4 9.1 0.7 2.4 1 1 0 2 2 2 0 Fic/DOC family YabA PF06156.13 KOO52846.1 - 8.8 7.0 12.5 2.9 8.6 0.7 2.3 2 0 0 2 2 2 0 Initiation control protein YabA CRR7 PF12095.8 KOO52846.1 - 8.9 6.8 7.5 1.7 9.1 0.7 2.7 2 1 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 YjcZ PF13990.6 KOO52848.1 - 0.0016 17.9 3.5 0.021 14.2 2.6 2.2 1 1 0 1 1 1 1 YjcZ-like protein Filament PF00038.21 KOO52848.1 - 0.034 13.7 1.9 0.053 13.1 1.9 1.2 1 0 0 1 1 1 0 Intermediate filament protein Dynamitin PF04912.14 KOO52848.1 - 0.041 13.2 1.1 0.065 12.6 1.1 1.3 1 0 0 1 1 1 0 Dynamitin WASH-7_N PF14745.6 KOO52848.1 - 0.16 10.5 0.0 0.22 10.0 0.0 1.1 1 0 0 1 1 1 0 WASH complex subunit 7, N-terminal DUF4164 PF13747.6 KOO52848.1 - 0.21 11.9 10.2 0.048 13.9 1.5 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) GP41 PF00517.17 KOO52848.1 - 0.26 11.2 1.3 4.4 7.1 0.1 2.2 1 1 1 2 2 2 0 Retroviral envelope protein Spc7 PF08317.11 KOO52848.1 - 0.27 10.1 2.1 0.4 9.5 2.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Pyr_redox_2 PF07992.14 KOO52849.1 - 8.7e-43 146.6 0.9 8.7e-43 146.6 0.9 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOO52849.1 - 2.9e-28 98.3 0.5 5.2e-28 97.5 0.5 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOO52849.1 - 1.7e-14 54.1 0.4 6.1e-14 52.3 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOO52849.1 - 2.3e-08 33.6 0.0 3.6e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 KOO52849.1 - 0.0094 15.3 0.2 3.7 6.9 0.0 2.8 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K_oxygenase PF13434.6 KOO52849.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pkinase PF00069.25 KOO52850.1 - 7.1e-51 173.1 0.0 8.5e-51 172.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO52850.1 - 2.8e-37 128.4 0.0 3.5e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO52850.1 - 3.4e-05 22.8 0.0 5.1e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO52850.1 - 0.0067 15.8 0.0 0.0098 15.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like EF-hand_5 PF13202.6 KOO52851.1 - 0.0011 18.3 0.2 0.0024 17.3 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KOO52851.1 - 0.014 14.9 0.1 0.03 13.9 0.1 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KOO52851.1 - 0.037 14.5 0.0 0.094 13.2 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO52851.1 - 0.052 13.5 0.1 0.14 12.1 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain Bestrophin PF01062.21 KOO52852.1 - 3.3e-15 56.3 0.0 8.7e-15 54.9 0.0 1.6 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Cation_efflux PF01545.21 KOO52853.1 - 4.1e-15 56.0 6.2 6.3e-15 55.4 6.2 1.3 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 KOO52853.1 - 5.9e-08 32.7 0.2 1.5e-07 31.4 0.2 1.7 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter LRR_9 PF14580.6 KOO52854.1 - 5.6e-10 39.0 0.5 1e-09 38.2 0.5 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KOO52854.1 - 4.7e-06 26.8 11.2 0.0044 17.4 1.3 3.3 1 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO52854.1 - 0.00012 21.7 8.5 0.0007 19.3 2.9 2.8 1 1 2 3 3 3 3 Leucine rich repeat PIH1_CS PF18201.1 KOO52854.1 - 0.093 13.2 0.0 0.27 11.7 0.0 1.7 1 0 0 1 1 1 0 PIH1 CS-like domain FANC_SAP PF18081.1 KOO52854.1 - 0.33 11.1 3.0 10 6.4 0.0 3.0 2 0 0 2 2 2 0 Fanconi anemia-associated nuclease SAP domain EF-hand_1 PF00036.32 KOO52856.1 - 4e-14 51.0 1.4 1.1e-05 24.6 0.2 3.3 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KOO52856.1 - 6.5e-12 44.4 0.5 1.3e-05 24.5 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO52856.1 - 1e-11 45.1 1.9 3.1e-11 43.6 0.3 2.3 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO52856.1 - 2.7e-11 42.5 0.5 0.00016 21.3 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KOO52856.1 - 1.8e-06 27.7 1.6 1.2e-05 25.0 0.5 3.6 3 2 2 5 5 5 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO52856.1 - 0.00094 19.5 0.8 0.00094 19.5 0.8 2.0 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO52856.1 - 0.0044 16.9 0.4 0.012 15.5 0.2 1.8 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Rad52_Rad22 PF04098.15 KOO52856.1 - 0.0097 15.8 0.2 0.03 14.2 0.0 1.9 2 0 0 2 2 2 1 Rad52/22 family double-strand break repair protein Toprim_N PF08275.11 KOO52856.1 - 0.084 12.9 0.0 0.18 11.9 0.0 1.8 1 1 1 2 2 2 0 DNA primase catalytic core, N-terminal domain VKG_Carbox PF05090.14 KOO52857.1 - 0.48 9.2 1.1 0.44 9.3 0.0 1.4 2 0 0 2 2 2 0 Vitamin K-dependent gamma-carboxylase PNGaseA PF12222.8 KOO52858.1 - 3.8e-64 217.2 0.0 5.9e-64 216.5 0.0 1.2 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Gly_transf_sug PF04488.15 KOO52859.1 - 0.0017 18.9 0.0 0.0032 18.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 KOO52859.1 - 0.026 13.9 0.0 0.035 13.5 0.0 1.1 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein BET PF17035.5 KOO52860.1 - 0.049 13.8 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation DUF5543 PF17697.1 KOO52862.1 - 0.025 14.9 0.1 0.028 14.7 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5543) SNF2_N PF00176.23 KOO52864.1 - 6.7e-08 31.6 0.0 1.1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain SAP PF02037.27 KOO52864.1 - 2.2e-07 30.5 1.3 4e-07 29.6 0.4 2.0 2 0 0 2 2 2 1 SAP domain ResIII PF04851.15 KOO52864.1 - 0.00018 21.6 0.0 0.0005 20.1 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit TEBP_beta PF07404.11 KOO52864.1 - 1.8 7.8 5.2 4.8 6.4 5.2 1.6 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) Arm PF00514.23 KOO52865.1 - 0.028 14.4 0.3 1.7 8.8 0.0 2.8 3 1 0 3 3 3 0 Armadillo/beta-catenin-like repeat Aldedh PF00171.22 KOO52866.1 - 1.5e-90 304.0 0.2 1.8e-90 303.7 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 KOO52866.1 - 0.028 13.9 0.0 0.047 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Mito_carr PF00153.27 KOO52867.1 - 3.2e-12 46.2 1.0 0.0004 20.2 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein QCR10 PF09796.9 KOO52867.1 - 0.15 12.1 2.4 2.6 8.2 0.2 2.8 3 0 0 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) C2 PF00168.30 KOO52868.1 - 2.9e-06 27.5 0.0 6.3e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain FXMR_C2 PF16098.5 KOO52868.1 - 0.14 12.7 0.2 0.14 12.7 0.2 3.1 3 1 0 3 3 3 0 Fragile X-related mental retardation protein C-terminal region 2 YcgL PF05166.13 KOO52868.1 - 0.36 11.2 1.8 10 6.5 0.1 3.2 3 0 0 3 3 3 0 YcgL domain WD40 PF00400.32 KOO52869.1 - 1.6e-62 206.0 39.2 1.5e-08 35.2 0.5 9.7 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO52869.1 - 4.9e-15 55.6 7.8 0.13 12.6 0.1 8.4 4 1 5 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain APAF1_C PF17908.1 KOO52869.1 - 1.2e-12 48.0 0.0 6.9e-05 22.9 0.0 2.7 3 0 0 3 3 2 2 APAF-1 helical domain Ge1_WD40 PF16529.5 KOO52869.1 - 1.5e-12 47.1 5.8 0.59 9.0 0.0 7.2 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO52869.1 - 1.6e-10 40.7 6.2 2.7 8.0 0.0 7.1 7 0 0 7 7 7 4 WD40-like Beta Propeller Repeat AAA_16 PF13191.6 KOO52869.1 - 2.2e-08 34.7 0.1 7.1e-08 33.0 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 KOO52869.1 - 7.8e-08 32.4 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DCX PF03607.17 KOO52869.1 - 2.8e-06 27.3 0.0 6.9 6.9 0.0 6.9 7 0 0 7 7 7 1 Doublecortin Frtz PF11768.8 KOO52869.1 - 0.00064 18.2 0.1 1.2 7.4 0.0 3.6 2 1 2 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz KAP_NTPase PF07693.14 KOO52869.1 - 0.0073 15.6 0.1 1.2 8.3 0.0 2.5 2 1 0 3 3 3 1 KAP family P-loop domain PIF1 PF05970.14 KOO52869.1 - 0.13 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase AAA_2 PF07724.14 KOO52870.1 - 6.2e-52 176.2 0.0 4e-50 170.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 KOO52870.1 - 1.8e-25 88.9 0.3 5.1e-25 87.4 0.0 1.9 2 0 0 2 2 1 1 AAA lid domain AAA PF00004.29 KOO52870.1 - 1.4e-24 87.0 0.0 4.2e-13 49.9 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOO52870.1 - 1.4e-17 64.0 0.0 5.9e-13 49.0 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 KOO52870.1 - 1.1e-13 51.0 0.0 4.1e-13 49.2 0.0 2.1 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein Sigma54_activat PF00158.26 KOO52870.1 - 8.7e-10 38.6 0.0 9e-06 25.5 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 KOO52870.1 - 6.4e-08 33.0 0.7 0.0074 16.6 0.1 4.5 2 2 0 2 2 2 2 AAA domain TniB PF05621.11 KOO52870.1 - 3.7e-07 29.7 0.0 0.0015 18.0 0.0 3.5 2 1 0 2 2 2 1 Bacterial TniB protein IstB_IS21 PF01695.17 KOO52870.1 - 6.5e-07 29.2 0.0 0.035 13.9 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 KOO52870.1 - 1.2e-06 28.0 0.5 0.35 10.2 0.1 3.8 3 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KOO52870.1 - 1.4e-06 28.8 15.2 0.00021 21.7 0.0 5.3 5 1 0 6 6 5 2 AAA ATPase domain Clp_N PF02861.20 KOO52870.1 - 3.1e-06 27.2 2.0 1.3e-05 25.2 0.7 2.5 2 0 0 2 2 2 1 Clp amino terminal domain, pathogenicity island component RuvB_N PF05496.12 KOO52870.1 - 1.8e-05 24.5 1.1 1.7 8.4 0.0 4.2 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KOO52870.1 - 3.9e-05 24.2 0.0 0.078 13.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 KOO52870.1 - 0.00022 20.8 0.0 0.2 11.2 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_30 PF13604.6 KOO52870.1 - 0.00034 20.4 0.0 0.26 11.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 KOO52870.1 - 0.00046 20.2 0.0 0.69 9.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 KOO52870.1 - 0.00057 19.8 0.0 0.2 11.5 0.0 2.9 2 1 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 KOO52870.1 - 0.00062 19.4 0.0 0.023 14.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO52870.1 - 0.00078 19.6 0.0 0.074 13.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KOO52870.1 - 0.0019 17.5 0.0 0.11 11.7 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin ATPase_2 PF01637.18 KOO52870.1 - 0.0045 16.9 0.1 21 5.0 0.0 3.5 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea Roc PF08477.13 KOO52870.1 - 0.0045 17.2 0.0 4.6 7.5 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 KOO52870.1 - 0.005 16.8 0.0 2.9 7.9 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE MCM PF00493.23 KOO52870.1 - 0.0072 15.4 0.0 2 7.5 0.0 2.6 2 1 0 2 2 2 1 MCM P-loop domain AAA_3 PF07726.11 KOO52870.1 - 0.012 15.5 0.2 1.5 8.6 0.1 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KOO52870.1 - 0.014 15.8 0.0 3.1 8.2 0.0 2.5 2 0 0 2 2 2 0 RNA helicase TIP49 PF06068.13 KOO52870.1 - 0.014 14.6 0.1 0.38 9.9 0.0 2.4 2 1 0 2 2 2 0 TIP49 P-loop domain RsgA_GTPase PF03193.16 KOO52870.1 - 0.017 15.0 0.0 3.5 7.5 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 KOO52870.1 - 0.022 14.5 0.0 6.1 6.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KOO52870.1 - 0.028 14.8 0.5 1 9.7 0.0 2.9 2 1 1 3 3 3 0 AAA domain DNA_pol3_delta2 PF13177.6 KOO52870.1 - 0.045 13.5 0.0 10 5.9 0.0 2.6 3 0 0 3 3 2 0 DNA polymerase III, delta subunit ABC_tran PF00005.27 KOO52870.1 - 0.049 14.2 0.0 1.5 9.4 0.0 2.5 2 0 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 KOO52870.1 - 0.055 13.4 0.2 18 5.2 0.0 3.2 3 0 0 3 3 3 0 NTPase AAA_23 PF13476.6 KOO52870.1 - 0.056 14.0 0.0 13 6.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KOO52870.1 - 0.083 13.1 0.0 27 4.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOO52870.1 - 0.09 12.5 0.0 12 5.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Torsin PF06309.11 KOO52870.1 - 0.13 12.3 0.0 0.86 9.7 0.0 2.0 2 0 0 2 2 2 0 Torsin Parvo_NS1 PF01057.17 KOO52870.1 - 0.23 10.5 0.0 8.8 5.3 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 RRM_1 PF00076.22 KOO52871.1 - 1.9e-12 46.8 0.0 2.8e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 KOO52871.1 - 9.8e-08 31.7 10.7 0.00031 20.6 2.5 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOO52871.1 - 8.7e-06 25.6 19.4 0.0066 16.5 6.3 2.3 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 KOO52871.1 - 3.6e-05 24.4 0.6 0.21 12.3 0.1 2.3 2 0 0 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 KOO52871.1 - 0.045 13.6 2.4 0.045 13.6 2.4 2.3 2 0 0 2 2 2 0 CCCH-type zinc finger FtsJ PF01728.19 KOO52872.1 - 0.011 15.8 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PARP PF00644.20 KOO52873.1 - 1e-11 44.8 0.1 5.4e-11 42.5 0.1 2.1 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain HC2 PF07382.11 KOO52873.1 - 0.00091 19.4 10.6 0.0016 18.6 10.6 1.3 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Ribosomal_L37 PF08561.10 KOO52873.1 - 1.1 9.8 8.7 16 6.0 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 ACC_central PF08326.12 KOO52875.1 - 2.1e-32 112.2 0.0 2.7e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Biotin_lipoyl PF00364.22 KOO52875.1 - 1e-05 25.3 0.4 3.9e-05 23.4 0.4 2.0 1 1 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KOO52875.1 - 0.1 12.5 0.1 2.8 7.8 0.0 2.7 2 0 0 2 2 2 0 Biotin-lipoyl like ABC2_membrane PF01061.24 KOO52876.1 - 1.1e-32 113.2 22.8 1.1e-32 113.2 22.8 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KOO52876.1 - 3.7e-09 37.2 0.0 5.6e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOO52876.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system PDR_CDR PF06422.12 KOO52876.1 - 0.013 15.4 0.1 0.013 15.4 0.1 3.0 2 1 1 3 3 3 0 CDR ABC transporter Methyltransf_16 PF10294.9 KOO52877.1 - 7.7e-14 51.8 0.0 2.3e-11 43.7 0.0 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Metallophos PF00149.28 KOO52878.1 - 1.8e-13 51.5 3.1 2.5e-13 51.0 3.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Yae1_N PF09811.9 KOO52879.1 - 2.6e-06 27.0 9.4 4.2e-06 26.3 9.4 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Chorion_3 PF05387.11 KOO52879.1 - 4.4 6.9 4.8 6 6.4 4.8 1.2 1 0 0 1 1 1 0 Chorion family 3 EF-hand_7 PF13499.6 KOO52880.1 - 2.8e-24 85.3 2.7 5.4e-10 39.6 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO52880.1 - 5.3e-24 81.9 1.3 2.5e-05 23.5 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO52880.1 - 1.3e-20 71.5 3.9 0.00018 21.2 0.0 4.8 5 0 0 5 5 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO52880.1 - 7.6e-18 64.1 0.3 2.9e-05 23.8 0.0 4.2 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO52880.1 - 2.9e-17 61.3 7.9 7.7e-05 22.0 0.8 4.4 4 0 0 4 4 4 4 EF hand EF-hand_4 PF12763.7 KOO52880.1 - 5.8e-05 23.0 0.9 0.24 11.4 0.0 3.4 4 0 0 4 4 4 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOO52880.1 - 6.7e-05 23.0 1.1 0.29 11.3 0.0 4.0 4 0 0 4 4 4 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KOO52880.1 - 0.0025 18.1 0.4 35 4.8 0.1 4.1 2 2 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Cleaved_Adhesin PF07675.11 KOO52880.1 - 0.04 13.9 0.8 0.27 11.1 0.0 2.4 2 1 1 3 3 3 0 Cleaved Adhesin Domain B_lectin PF01453.24 KOO52880.1 - 0.13 12.9 0.0 20 5.8 0.0 2.8 2 1 1 3 3 3 0 D-mannose binding lectin Stork_head PF10264.9 KOO52880.1 - 0.16 12.1 0.0 0.74 10.0 0.0 2.1 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain DUF4376 PF14301.6 KOO52880.1 - 0.19 12.1 2.2 0.34 11.3 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4376) Baculo_PEP_C PF04513.12 KOO52880.1 - 3.5 7.7 5.7 28 4.7 0.0 3.6 3 2 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus EF-hand_7 PF13499.6 KOO52883.1 - 5.6e-24 84.4 2.1 2e-08 34.5 0.0 3.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO52883.1 - 1.3e-21 74.6 4.5 0.00026 20.7 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO52883.1 - 3e-19 67.0 2.6 0.001 18.5 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 KOO52883.1 - 9.2e-17 59.7 3.3 0.0029 17.0 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO52883.1 - 3.8e-16 58.7 0.1 1.1e-07 31.6 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair HAD_2 PF13419.6 KOO52883.1 - 9.6e-10 38.8 0.0 1.8e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOO52883.1 - 1.3e-07 31.5 0.1 4.3e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 KOO52883.1 - 2.9e-06 27.7 0.1 4.9e-06 27.0 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Caleosin PF05042.13 KOO52883.1 - 0.0015 18.5 0.1 8.7 6.2 0.1 3.2 2 1 1 3 3 3 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 KOO52883.1 - 0.018 15.4 0.0 29 5.0 0.0 3.4 2 2 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 KOO52884.1 - 8.4e-14 50.3 0.1 2.1e-08 33.3 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO52884.1 - 1.8e-13 49.2 0.4 2.2e-05 24.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO52884.1 - 2.2e-13 48.7 0.1 9.5e-06 24.8 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO52884.1 - 3.7e-09 36.9 0.0 0.0023 18.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO52884.1 - 1.8e-08 34.1 0.0 0.0019 18.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair TT_ORF2 PF02957.15 KOO52884.1 - 0.025 15.5 0.5 0.065 14.2 0.5 1.7 1 0 0 1 1 1 0 TT viral ORF2 Dockerin_1 PF00404.18 KOO52884.1 - 0.18 12.0 0.0 0.52 10.5 0.0 1.7 1 0 0 1 1 1 0 Dockerin type I domain DUF4542 PF15075.6 KOO52885.1 - 0.16 12.4 0.5 0.42 11.0 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4542) IQ PF00612.27 KOO52888.1 - 0.15 12.0 0.3 0.33 10.9 0.3 1.5 1 0 0 1 1 1 0 IQ calmodulin-binding motif SAC3_GANP PF03399.16 KOO52892.1 - 8.3e-30 104.2 0.4 3e-28 99.0 0.4 2.0 1 1 0 1 1 1 1 SAC3/GANP family ABC1 PF03109.16 KOO52893.1 - 6e-32 110.3 0.0 1.5e-31 109.0 0.0 1.7 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO52893.1 - 0.0003 20.8 0.0 0.0051 16.8 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Ion_trans PF00520.31 KOO52894.1 - 5.2e-13 48.8 5.7 1.1e-12 47.8 5.7 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO52894.1 - 3.1e-06 27.1 5.4 3.1e-06 27.1 5.4 1.9 2 0 0 2 2 2 1 Ion channel Pkinase_Tyr PF07714.17 KOO52895.1 - 2.7e-08 33.4 0.0 4.7e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO52895.1 - 1.2e-06 28.1 0.0 3.4e-06 26.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain CRC_subunit PF08624.10 KOO52895.1 - 0.035 14.5 0.0 0.39 11.2 0.0 2.2 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit Peptidase_C2 PF00648.21 KOO52895.1 - 0.088 11.8 1.2 0.19 10.7 0.3 1.8 2 0 0 2 2 2 0 Calpain family cysteine protease Pyr_redox_2 PF07992.14 KOO52898.1 - 2.8e-07 30.1 0.0 4.6e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO52898.1 - 8.9e-07 29.4 0.0 2.5e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO52898.1 - 8e-06 25.7 0.3 0.0082 15.8 0.3 3.2 2 1 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 KOO52898.1 - 3.8e-05 22.6 0.0 6.5e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 KOO52898.1 - 0.00011 22.3 0.0 0.0004 20.5 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOO52898.1 - 0.00014 21.2 0.1 0.00021 20.6 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOO52898.1 - 0.00085 18.5 0.1 0.0024 17.0 0.1 1.8 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 KOO52898.1 - 0.0059 15.9 0.2 0.013 14.8 0.1 1.5 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 KOO52898.1 - 0.05 12.9 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 Thi4 family 2-Hacid_dh_C PF02826.19 KOO52898.1 - 0.088 12.2 0.1 1 8.7 0.0 2.6 3 1 1 4 4 4 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 KOO52898.1 - 0.14 11.6 0.0 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus LRR_6 PF13516.6 KOO52899.1 - 1.9e-05 24.3 4.0 0.25 11.5 0.0 4.2 4 0 0 4 4 4 3 Leucine Rich repeat STAS_2 PF13466.6 KOO52899.1 - 0.083 13.2 0.8 0.083 13.2 0.8 2.3 2 1 0 2 2 2 0 STAS domain 4HB_MCP_1 PF12729.7 KOO52900.1 - 0.037 13.6 0.4 0.073 12.6 0.4 1.4 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction RPAP3_C PF13877.6 KOO52901.1 - 1.2e-10 41.7 0.0 4.3e-10 40.0 0.0 2.0 2 0 0 2 2 2 1 Potential Monad-binding region of RPAP3 TPR_1 PF00515.28 KOO52901.1 - 2e-07 30.5 11.9 0.00059 19.5 0.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO52901.1 - 8.9e-06 26.3 29.5 7.6e-05 23.3 9.8 5.7 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO52901.1 - 0.00015 21.6 20.1 0.0094 16.0 0.8 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO52901.1 - 0.003 17.2 3.3 1.2 8.9 1.4 2.8 2 1 0 2 2 2 2 TPR repeat TPR_12 PF13424.6 KOO52901.1 - 0.0085 16.4 11.6 0.17 12.2 5.9 3.3 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO52901.1 - 0.024 14.6 3.7 5.7 7.2 0.0 4.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO52901.1 - 0.23 11.8 10.7 19 5.8 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO52901.1 - 4.3 8.2 16.6 39 5.2 0.2 5.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TonB_C PF03544.14 KOO52902.1 - 0.12 12.9 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Gram-negative bacterial TonB protein C-terminal PAN_4 PF14295.6 KOO52903.1 - 0.0041 17.0 1.3 0.014 15.3 1.3 1.9 1 0 0 1 1 1 1 PAN domain RCC1 PF00415.18 KOO52905.1 - 2.3e-28 98.5 8.2 7.2e-14 52.1 0.5 3.9 3 1 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO52905.1 - 1.6e-14 53.2 14.7 6.2e-08 32.3 0.3 4.2 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat DUF4355 PF14265.6 KOO52906.1 - 0.02 15.1 6.5 0.031 14.5 6.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) Thioesterase PF00975.20 KOO52906.1 - 0.021 14.9 1.0 0.026 14.6 1.0 1.1 1 0 0 1 1 1 0 Thioesterase domain tify PF06200.14 KOO52907.1 - 0.18 11.1 0.4 0.44 9.9 0.4 1.7 1 0 0 1 1 1 0 tify domain COX6B PF02297.17 KOO52908.1 - 0.063 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb MCM PF00493.23 KOO52910.1 - 6.2e-104 346.0 0.1 9.2e-104 345.4 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOO52910.1 - 2.4e-35 121.1 0.6 7.5e-35 119.5 0.3 1.9 1 1 1 2 2 2 1 MCM OB domain MCM_lid PF17855.1 KOO52910.1 - 1.4e-25 89.5 1.3 3.2e-25 88.3 1.3 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KOO52910.1 - 1.6e-20 73.6 1.5 2.7e-19 69.7 0.4 2.9 3 0 0 3 3 3 1 MCM N-terminal domain MCM6_C PF18263.1 KOO52910.1 - 5.8e-17 61.9 0.5 2.2e-16 60.0 0.4 2.0 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain Mg_chelatase PF01078.21 KOO52910.1 - 8.9e-07 28.5 0.0 6.5e-06 25.7 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOO52910.1 - 0.00025 21.1 0.0 0.00062 19.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KOO52910.1 - 0.0018 18.2 0.0 0.0038 17.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOO52910.1 - 0.0035 17.1 0.1 0.0076 16.0 0.1 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_lid_7 PF17867.1 KOO52910.1 - 0.053 13.7 0.3 0.85 9.9 0.1 2.5 2 0 0 2 2 2 0 Midasin AAA lid domain SpoU_methylase PF00588.19 KOO52912.1 - 1.3e-09 38.4 0.0 1.7e-09 37.9 0.0 1.4 1 1 0 1 1 1 1 SpoU rRNA Methylase family Spore_YtfJ PF09579.10 KOO52912.1 - 0.23 11.6 3.8 0.48 10.6 3.8 1.5 1 0 0 1 1 1 0 Sporulation protein YtfJ (Spore_YtfJ) CHORD PF04968.12 KOO52914.1 - 8.7e-43 144.9 19.1 9.3e-22 77.5 3.9 2.2 2 0 0 2 2 2 2 CHORD TRAM_LAG1_CLN8 PF03798.16 KOO52916.1 - 0.0056 16.4 1.7 0.0092 15.7 1.7 1.4 1 1 0 1 1 1 1 TLC domain Peptidase_M50B PF13398.6 KOO52917.1 - 2.2e-06 27.4 8.4 5.8e-06 26.1 8.4 1.7 1 1 0 1 1 1 1 Peptidase M50B-like Polysacc_synt PF01943.17 KOO52917.1 - 0.2 11.0 2.1 0.4 10.0 2.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ABC2_membrane_3 PF12698.7 KOO52917.1 - 0.25 10.4 1.8 0.34 10.0 1.8 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3267 PF11667.8 KOO52917.1 - 1.2 9.5 7.3 0.4 11.0 3.4 2.1 2 1 1 3 3 3 0 Putative zincin peptidase zf-Tim10_DDP PF02953.15 KOO52918.1 - 1.4e-20 72.7 1.2 1.7e-20 72.4 1.2 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Peptidase_C34 PF05413.11 KOO52918.1 - 0.011 16.0 0.2 0.014 15.6 0.2 1.3 1 0 0 1 1 1 0 Putative closterovirus papain-like endopeptidase Erf4 PF10256.9 KOO52918.1 - 0.13 12.3 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family KIAA1430 PF13879.6 KOO52919.1 - 1.2e-06 29.2 11.8 0.021 15.6 0.8 3.3 2 1 1 3 3 3 3 KIAA1430 homologue Herpes_BLRF2 PF05812.12 KOO52919.1 - 0.0058 16.8 12.5 1.1 9.4 0.3 4.2 2 1 2 4 4 4 2 Herpesvirus BLRF2 protein FlaC_arch PF05377.11 KOO52919.1 - 0.39 11.2 4.6 2.9 8.3 0.1 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 KOO52919.1 - 3.8 8.2 9.0 8.8 7.0 0.5 3.5 3 0 0 3 3 3 0 SlyX SR-25 PF10500.9 KOO52921.1 - 0.097 12.3 12.5 0.15 11.7 12.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ScsC_N PF18312.1 KOO52922.1 - 1.3 8.9 5.1 2.5 8.0 0.0 2.8 3 0 0 3 3 3 0 Copper resistance protein ScsC N-terminal domain Rotamase PF00639.21 KOO52923.1 - 5.6e-14 52.9 0.0 1.2e-13 51.8 0.0 1.6 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOO52923.1 - 1.6e-13 51.2 0.0 3.2e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 PPIC-type PPIASE domain Glyco_transf_28 PF03033.20 KOO52923.1 - 8.8e-13 48.5 0.0 1.7e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 KOO52923.1 - 2e-06 26.9 0.0 2.4e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_4 PF13439.6 KOO52923.1 - 0.0015 18.6 0.0 0.0053 16.8 0.0 2.0 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_tran_28_C PF04101.16 KOO52923.1 - 0.0068 16.4 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain 2-Hacid_dh_C PF02826.19 KOO52925.1 - 4.7e-42 143.3 0.0 1.5e-41 141.7 0.0 1.8 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOO52925.1 - 2.1e-19 69.5 0.0 3.3e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOO52925.1 - 0.00042 20.5 0.1 0.00077 19.7 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 KOO52925.1 - 0.029 14.9 0.6 0.81 10.2 0.2 2.6 2 1 0 2 2 2 0 XdhC Rossmann domain RPGR1_C PF18111.1 KOO52927.1 - 0.0011 19.0 0.0 0.8 9.6 0.0 2.9 3 0 0 3 3 3 2 Retinitis pigmentosa G-protein regulator interacting C-terminal 2OG-FeII_Oxy_3 PF13640.6 KOO52928.1 - 1.8e-06 28.7 0.0 3.4e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily NDK PF00334.19 KOO52931.1 - 1.5e-38 131.8 0.0 1.9e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase GNAT_acetyltran PF12746.7 KOO52932.1 - 0.15 11.6 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase ATP12 PF07542.11 KOO52933.1 - 8.8e-30 103.4 0.0 1.4e-29 102.8 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Pkinase PF00069.25 KOO52934.1 - 2.8e-46 158.0 0.0 3.3e-46 157.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO52934.1 - 3.5e-20 72.4 0.0 4.3e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO52934.1 - 0.0019 17.6 0.0 0.0031 16.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO52934.1 - 0.0093 14.8 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DnaJ PF00226.31 KOO52935.1 - 1.4e-21 76.4 0.1 2.3e-21 75.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1542 PF07564.11 KOO52935.1 - 0.031 14.4 0.2 0.046 13.8 0.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) UvdE PF03851.14 KOO52935.1 - 0.089 12.0 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 UV-endonuclease UvdE KinB_sensor PF16767.5 KOO52935.1 - 0.14 12.6 0.5 0.2 12.1 0.5 1.3 1 0 0 1 1 1 0 Sensor domain of alginate biosynthesis sensor protein KinB Adhesin_P1_N PF18652.1 KOO52935.1 - 0.15 12.1 0.6 0.15 12.1 0.6 2.1 1 1 1 2 2 2 0 Adhesin P1 N-terminal domain Lge1 PF11488.8 KOO52935.1 - 0.22 11.7 1.6 0.57 10.4 1.0 1.9 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 DENN PF02141.21 KOO52936.1 - 6.7e-11 42.5 0.8 1.6e-08 34.8 0.0 3.1 4 0 0 4 4 4 2 DENN (AEX-3) domain PDZ_6 PF17820.1 KOO52936.1 - 5.6e-06 26.1 0.1 1.2e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO52936.1 - 2.5e-05 24.6 0.1 5.1e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO52936.1 - 0.0008 19.7 0.0 0.0018 18.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain uDENN PF03456.18 KOO52936.1 - 0.0065 17.2 0.0 0.015 16.0 0.0 1.6 1 0 0 1 1 1 1 uDENN domain DUF2236 PF09995.9 KOO52937.1 - 2e-10 41.3 4.2 3.3e-05 24.2 0.6 2.3 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2236) FA_hydroxylase PF04116.13 KOO52938.1 - 6.7e-15 55.6 16.0 6.7e-15 55.6 16.0 1.5 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Lipase_GDSL_2 PF13472.6 KOO52939.1 - 0.024 15.0 0.0 0.05 14.0 0.0 1.7 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Pyr_redox_2 PF07992.14 KOO52940.1 - 1e-23 84.0 0.6 2.8e-20 72.7 0.0 1.4 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOO52940.1 - 8.5e-07 28.4 0.0 0.0031 16.7 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 KOO52940.1 - 2.8e-05 24.6 0.1 0.082 13.5 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOO52940.1 - 0.013 15.1 0.1 0.042 13.4 0.0 1.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KOO52940.1 - 0.047 12.9 0.0 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase LRR_6 PF13516.6 KOO52941.1 - 8.1e-11 41.1 2.8 0.00069 19.5 0.0 3.8 3 0 0 3 3 3 3 Leucine Rich repeat Sfi1 PF08457.10 KOO52941.1 - 6 5.3 88.8 1.2 7.6 17.3 5.0 2 1 1 4 4 4 0 Sfi1 spindle body protein WD40 PF00400.32 KOO52942.1 - 1.5e-37 126.9 16.5 3.2e-07 30.9 0.2 8.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO52942.1 - 1.3e-12 47.9 1.2 0.0081 16.4 0.1 4.8 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOO52942.1 - 7.4e-08 31.7 0.8 0.65 8.9 0.0 5.0 2 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 KOO52942.1 - 6.4e-06 24.9 0.6 0.41 9.1 0.0 3.5 2 1 1 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 KOO52942.1 - 6.7e-05 22.7 0.1 3.7 7.6 0.0 4.1 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 KOO52942.1 - 0.00035 20.6 0.2 1.8 8.6 0.0 4.0 2 1 2 4 4 4 1 Ciliary BBSome complex subunit 2, middle region NACHT PF05729.12 KOO52942.1 - 0.0005 20.0 0.1 0.0016 18.4 0.1 1.9 1 1 0 1 1 1 1 NACHT domain WW PF00397.26 KOO52942.1 - 0.011 15.8 1.9 0.05 13.7 1.9 2.2 1 1 0 1 1 1 0 WW domain RRM_1 PF00076.22 KOO52942.1 - 0.047 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_19 PF13245.6 KOO52942.1 - 0.077 13.3 0.3 0.2 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain Agenet PF05641.12 KOO52943.1 - 1.3e-24 86.4 16.1 5.6e-08 33.1 0.0 6.6 7 0 0 7 7 7 3 Agenet domain GRIP PF01465.20 KOO52943.1 - 9.2e-11 41.5 0.2 2e-10 40.4 0.2 1.6 1 0 0 1 1 1 1 GRIP domain GOLGA2L5 PF15070.6 KOO52943.1 - 0.018 13.7 0.7 0.029 13.0 0.7 1.2 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 APG6_N PF17675.1 KOO52943.1 - 0.038 14.5 1.0 0.11 13.0 1.0 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region CA_like PF10563.9 KOO52943.1 - 0.065 13.2 0.0 1.7 8.6 0.0 2.3 2 0 0 2 2 2 0 Putative carbonic anhydrase Fez1 PF06818.15 KOO52943.1 - 0.074 13.5 1.6 0.13 12.7 1.6 1.3 1 0 0 1 1 1 0 Fez1 Spc7 PF08317.11 KOO52943.1 - 0.095 11.6 2.6 0.15 10.9 2.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Peptidase_S49_N PF08496.10 KOO52943.1 - 0.25 11.4 2.1 0.52 10.4 2.1 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal NT-C2 PF10358.9 KOO52944.1 - 4.5e-05 23.2 0.0 7.1e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Tup_N PF08581.10 KOO52944.1 - 1.8 8.9 14.0 1.2 9.4 1.2 3.7 4 0 0 4 4 4 0 Tup N-terminal Hamartin PF04388.12 KOO52944.1 - 2.7 6.6 9.0 4.2 5.9 9.0 1.2 1 0 0 1 1 1 0 Hamartin protein Aldo_ket_red PF00248.21 KOO52945.1 - 2.6e-43 148.3 0.0 3.7e-43 147.8 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family CC2-LZ PF16516.5 KOO52946.1 - 7.2 7.0 11.8 3.4 8.1 0.4 3.3 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Sds3 PF08598.11 KOO52949.1 - 9.8e-07 29.0 3.9 2.9e-06 27.4 3.3 1.9 2 0 0 2 2 2 1 Sds3-like Big_3_3 PF13750.6 KOO52949.1 - 0.011 15.4 0.0 0.041 13.5 0.0 1.7 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) Asp PF00026.23 KOO52950.1 - 1.4e-98 330.2 0.0 3.4e-98 329.0 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOO52950.1 - 7.4e-12 45.9 4.0 6.7e-10 39.5 0.3 2.8 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOO52950.1 - 4.5e-05 24.0 0.2 0.33 11.6 0.0 3.3 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 KOO52950.1 - 0.00037 20.3 0.0 0.0011 18.8 0.0 1.8 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Na_Ca_ex PF01699.24 KOO52951.1 - 2.9e-37 127.9 39.4 3.6e-20 72.5 14.5 2.6 2 1 0 2 2 2 2 Sodium/calcium exchanger protein EF-hand_7 PF13499.6 KOO52952.1 - 1.4e-13 51.1 0.2 1.2e-09 38.5 0.3 1.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO52952.1 - 9.8e-11 40.7 0.2 7.2e-05 22.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO52952.1 - 3.6e-09 35.5 1.5 0.0003 20.1 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO52952.1 - 3.8e-08 32.5 1.2 1.8e-05 24.0 0.0 2.6 2 1 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO52952.1 - 5.7e-05 22.9 0.1 0.081 12.8 0.0 2.6 3 0 0 3 3 3 2 EF-hand domain pair TetR_C_31 PF17940.1 KOO52952.1 - 0.01 16.0 1.5 0.017 15.3 0.6 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF2075 PF09848.9 KOO52952.1 - 0.055 12.7 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SPARC_Ca_bdg PF10591.9 KOO52952.1 - 0.13 12.6 0.0 1.3 9.4 0.0 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region LRR_6 PF13516.6 KOO52954.1 - 3.6e-31 104.5 16.1 4.6e-05 23.1 0.0 8.5 11 0 0 11 11 11 6 Leucine Rich repeat Ank_4 PF13637.6 KOO52954.1 - 5.8e-23 81.0 4.3 9.1e-09 35.7 0.1 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO52954.1 - 8.6e-22 76.9 6.5 1.4e-10 41.2 0.4 2.9 2 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO52954.1 - 3.7e-19 68.3 1.3 2.2e-06 27.9 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 KOO52954.1 - 7.6e-19 68.1 4.3 6.3e-11 42.7 0.1 3.4 2 2 2 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO52954.1 - 4.4e-13 48.1 0.3 0.0062 17.0 0.0 4.0 4 0 0 4 4 3 3 Ankyrin repeat LRR_4 PF12799.7 KOO52954.1 - 1.3e-05 25.5 0.2 1.8 9.1 0.1 4.4 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO52954.1 - 0.0013 18.4 0.7 0.81 9.5 0.5 4.6 4 1 1 5 5 5 1 Leucine rich repeat DUF4235 PF14019.6 KOO52954.1 - 0.0044 17.1 0.7 3.6 7.7 0.1 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF4235) YycC PF14174.6 KOO52954.1 - 0.0069 16.2 0.0 8.5 6.3 0.0 4.5 6 0 0 6 6 6 1 YycC-like protein LRR_1 PF00560.33 KOO52954.1 - 0.033 14.7 0.0 1.6e+02 3.5 0.0 5.0 7 0 0 7 7 5 0 Leucine Rich Repeat FIST_C PF10442.9 KOO52954.1 - 0.18 11.8 1.9 11 6.1 1.9 2.7 1 1 0 1 1 1 0 FIST C domain SpoU_sub_bind PF08032.12 KOO52954.1 - 0.21 11.9 4.3 8.8 6.7 0.0 4.3 4 2 1 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding AbrB PF05145.12 KOO52954.1 - 1.2 8.1 6.1 10 5.0 0.5 2.7 3 0 0 3 3 3 0 Transition state regulatory protein AbrB CoatB PF10389.9 KOO52954.1 - 3.1 7.7 6.8 27 4.7 0.2 4.2 5 0 0 5 5 5 0 Bacteriophage coat protein B CbiG_N PF11760.8 KOO52954.1 - 8.8 6.4 17.8 6.9 6.8 0.1 5.4 6 0 0 6 6 6 0 Cobalamin synthesis G N-terminal EF-hand_7 PF13499.6 KOO52955.1 - 7.4e-06 26.3 0.0 1.6e-05 25.3 0.0 1.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO52955.1 - 0.00061 19.5 1.0 0.028 14.3 0.1 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KOO52955.1 - 0.0011 18.4 0.0 0.032 13.8 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOO52955.1 - 0.026 14.0 0.1 0.069 12.7 0.0 1.7 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 KOO52955.1 - 0.067 13.1 0.2 0.13 12.2 0.1 1.6 2 1 0 2 2 2 0 EF-hand domain pair DUF4476 PF14771.6 KOO52956.1 - 1.4e-17 63.7 0.0 2e-07 31.2 0.0 3.6 2 1 1 3 3 3 3 Domain of unknown function (DUF4476) F5_F8_type_C PF00754.25 KOO52956.1 - 5.8e-08 32.9 0.2 1.2e-07 31.9 0.2 1.5 1 0 0 1 1 1 1 F5/8 type C domain Arm PF00514.23 KOO52957.1 - 4.4e-99 321.9 64.1 6.7e-09 35.5 0.2 12.5 12 0 0 12 12 12 12 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO52957.1 - 6.1e-12 45.8 50.7 0.013 16.0 0.5 8.7 4 2 4 9 9 9 7 HEAT-like repeat CRS1_YhbY PF01985.21 KOO52957.1 - 1.1e-07 31.9 2.6 32 4.8 0.0 7.9 9 0 0 9 9 9 0 CRS1 / YhbY (CRM) domain Arm_2 PF04826.13 KOO52957.1 - 7.3e-07 28.9 17.2 0.032 13.7 0.4 4.9 1 1 4 5 5 5 5 Armadillo-like SNAD2 PF18745.1 KOO52957.1 - 1.5e-06 28.1 4.5 2.4 7.8 0.0 8.2 1 1 10 11 11 11 1 Secreted Novel AID/APOBEC-like Deaminase 2 Atx10homo_assoc PF09759.9 KOO52957.1 - 4.2e-06 26.7 20.2 0.015 15.3 0.4 7.0 4 3 3 7 7 7 3 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 KOO52957.1 - 0.0012 18.9 19.5 12 6.4 0.4 10.1 11 0 0 11 11 11 1 HEAT repeat KAP PF05804.12 KOO52957.1 - 0.0024 16.1 0.0 1.7 6.7 0.0 2.8 1 1 0 3 3 3 2 Kinesin-associated protein (KAP) Ig_mannosidase PF17753.1 KOO52957.1 - 0.017 14.9 14.4 1.2e+02 2.5 0.0 9.0 8 2 3 11 11 11 0 Ig-fold domain cNMP_binding PF00027.29 KOO52957.1 - 0.18 11.9 1.1 52 4.0 0.0 5.1 6 3 2 8 8 8 0 Cyclic nucleotide-binding domain EPOP PF15223.6 KOO52957.1 - 0.78 9.0 4.4 39 3.4 0.1 4.1 2 1 2 6 6 6 0 Elongin BC and Polycomb repressive complex 2-associated protein Phage_integrase PF00589.22 KOO52958.1 - 0.0014 18.4 0.1 0.076 12.8 0.0 2.5 2 0 0 2 2 2 2 Phage integrase family Ank_2 PF12796.7 KOO52959.1 - 4.6e-16 59.2 0.0 2.5e-13 50.4 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO52959.1 - 9.2e-16 57.7 0.3 1.2e-12 47.8 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO52959.1 - 3.4e-15 56.2 0.4 3.8e-07 30.5 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO52959.1 - 5.6e-11 42.4 0.1 4.7e-06 26.8 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KOO52959.1 - 9.8e-09 34.8 0.0 1.1e-05 25.4 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat Cupin_8 PF13621.6 KOO52960.1 - 1.2e-24 87.5 0.0 3.1e-23 82.8 0.0 2.1 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO52960.1 - 8.2e-06 25.5 0.4 0.0019 17.8 0.1 2.9 3 0 0 3 3 3 2 Cupin superfamily protein Cupin_2 PF07883.11 KOO52960.1 - 0.028 14.1 0.2 0.066 12.9 0.2 1.6 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.22 KOO52960.1 - 0.16 11.6 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Cupin SAM_2 PF07647.17 KOO52961.1 - 1e-10 41.5 1.7 1.2e-09 38.1 0.0 3.0 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KOO52961.1 - 1.5e-08 35.0 0.0 5.4e-08 33.2 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KOO52961.1 - 0.02 14.9 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain IGR PF09597.10 KOO52961.1 - 0.096 12.8 2.7 0.33 11.1 0.0 2.9 3 0 0 3 3 3 0 IGR protein motif ArdA PF07275.11 KOO52961.1 - 1 9.9 4.4 0.41 11.2 1.0 2.0 3 0 0 3 3 3 0 Antirestriction protein (ArdA) Sin3_corepress PF08295.12 KOO52961.1 - 1.3 9.2 7.7 4.6 7.4 0.1 2.7 3 0 0 3 3 3 0 Sin3 family co-repressor PARP PF00644.20 KOO52962.1 - 2.1e-16 60.1 0.0 5.2e-16 58.8 0.0 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain MHB PF16525.5 KOO52962.1 - 0.054 13.7 2.5 5.1 7.4 0.1 3.1 3 0 0 3 3 3 0 Haemophore, haem-binding MMPL PF03176.15 KOO52962.1 - 0.32 9.9 1.8 0.52 9.2 1.8 1.2 1 0 0 1 1 1 0 MMPL family TPT PF03151.16 KOO52964.1 - 2.6e-08 33.6 8.8 6.6e-08 32.3 8.8 1.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO52964.1 - 8.6e-06 26.0 26.3 0.00035 20.8 3.3 2.9 1 1 2 3 3 3 2 EamA-like transporter family TatC PF00902.18 KOO52964.1 - 0.21 11.4 10.8 0.34 10.7 10.8 1.3 1 0 0 1 1 1 0 Sec-independent protein translocase protein (TatC) CYYR1 PF10873.8 KOO52964.1 - 2.3 8.6 5.5 0.31 11.5 1.5 1.6 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 SBBP PF06739.11 KOO52965.1 - 2.1e-11 43.6 40.0 0.0021 18.0 2.6 5.1 5 0 0 5 5 5 4 Beta-propeller repeat DUF5514 PF17633.2 KOO52965.1 - 0.27 11.5 3.8 67 3.7 0.0 3.8 4 0 0 4 4 4 0 Family of unknown function (DUF5514) Keratin_2_head PF16208.5 KOO52965.1 - 0.29 11.3 49.3 1.2 9.3 9.0 4.1 1 1 3 4 4 4 0 Keratin type II head LRR_5 PF13306.6 KOO52967.1 - 1.1e-71 238.7 2.7 1.9e-35 121.6 0.4 2.1 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO52967.1 - 1.4e-10 40.8 0.0 0.064 13.0 0.0 6.8 3 2 6 9 9 9 4 Leucine rich repeat PilA4 PF18682.1 KOO52967.1 - 0.0034 17.7 12.0 16 5.9 0.2 6.5 2 2 6 8 8 8 3 Pilin A4 Peptidase_M8 PF01457.16 KOO52967.1 - 0.018 13.8 2.2 14 4.2 0.0 3.7 2 2 3 5 5 5 0 Leishmanolysin RVT_1 PF00078.27 KOO52973.1 - 0.0054 16.3 0.0 0.0076 15.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ApoC-I PF04691.12 KOO52973.1 - 0.17 11.9 0.9 30 4.7 0.5 2.9 2 1 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) ANTAR PF03861.14 KOO52974.1 - 0.031 14.1 0.2 0.13 12.2 0.2 2.1 1 0 0 1 1 1 0 ANTAR domain HGTP_anticodon PF03129.20 KOO52976.1 - 2.2e-23 82.2 0.1 5.1e-23 81.0 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KOO52976.1 - 6.4e-13 49.1 0.0 1.3e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS PF00458.20 KOO52976.1 - 3.5e-08 33.5 9.4 1.3e-07 31.7 9.3 2.0 1 1 0 1 1 1 1 WHEP-TRS domain HAD PF12710.7 KOO52979.1 - 3.5e-15 56.9 0.0 6.1e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOO52979.1 - 8.1e-13 49.1 1.1 4.7e-12 46.7 1.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Aph-1 PF06105.12 KOO52979.1 - 5.3e-07 29.3 7.8 7.6e-07 28.8 7.8 1.2 1 0 0 1 1 1 1 Aph-1 protein Acid_phosphat_B PF03767.14 KOO52979.1 - 0.00018 21.2 0.0 0.0071 16.0 0.0 2.1 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Put_Phosphatase PF06888.12 KOO52979.1 - 0.0002 20.8 0.0 0.00033 20.1 0.0 1.3 1 1 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.12 KOO52979.1 - 0.0022 17.6 0.0 0.0031 17.1 0.0 1.3 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hint PF01079.20 KOO52979.1 - 0.029 13.9 0.0 0.041 13.4 0.0 1.2 1 0 0 1 1 1 0 Hint module PglD_N PF17836.1 KOO52979.1 - 0.1 13.2 0.7 0.61 10.8 0.7 2.1 1 1 0 1 1 1 0 PglD N-terminal domain Pirin_C PF05726.13 KOO52980.1 - 2.3e-27 95.4 0.0 3.7e-27 94.7 0.0 1.3 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Pirin PF02678.16 KOO52980.1 - 5.4e-13 48.9 0.2 1.6e-12 47.4 0.2 1.8 1 0 0 1 1 1 1 Pirin cNMP_binding PF00027.29 KOO52983.1 - 1.6e-23 82.5 0.1 5.9e-13 48.7 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain SHIPPO-rpt PF07004.12 KOO52983.1 - 2.1e-10 41.0 12.8 0.027 15.4 0.1 6.3 6 0 0 6 6 6 3 Sperm-tail PG-rich repeat COPI_assoc PF08507.10 KOO52984.1 - 9.1e-12 45.2 4.0 1.2e-11 44.8 4.0 1.1 1 0 0 1 1 1 1 COPI associated protein DUF2781 PF10914.8 KOO52985.1 - 0.016 15.6 5.1 0.02 15.3 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2781) Tom7 PF08038.12 KOO52985.1 - 7.7 6.3 9.8 1.6 8.4 0.2 3.4 3 1 0 3 3 3 0 TOM7 family Cellulase PF00150.18 KOO52986.1 - 1e-11 44.8 0.0 1.4e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SLC35F PF06027.12 KOO52987.1 - 2.7e-69 234.0 3.7 3.5e-69 233.6 3.7 1.0 1 0 0 1 1 1 1 Solute carrier family 35 UAA PF08449.11 KOO52987.1 - 4.4e-08 32.7 0.3 6.2e-08 32.2 0.3 1.1 1 0 0 1 1 1 1 UAA transporter family CRT-like PF08627.10 KOO52987.1 - 9.9e-07 28.0 0.1 1.5e-06 27.4 0.1 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 KOO52987.1 - 6e-05 23.2 19.2 0.0034 17.5 2.8 2.4 2 0 0 2 2 2 2 EamA-like transporter family FUSC-like PF12805.7 KOO52987.1 - 0.64 9.1 7.4 0.089 11.9 0.6 2.7 2 2 0 2 2 2 0 FUSC-like inner membrane protein yccS Cullin PF00888.22 KOO52989.1 - 6.9e-186 619.5 7.9 1.1e-185 618.9 7.9 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KOO52989.1 - 1.3e-26 92.3 2.8 4.5e-26 90.7 1.2 2.7 3 0 0 3 3 3 1 Cullin protein neddylation domain BCDHK_Adom3 PF10436.9 KOO52989.1 - 0.084 12.7 0.4 0.28 11.0 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF2924 PF11149.8 KOO52989.1 - 0.55 10.6 4.1 17 5.8 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2924) SF3a60_bindingd PF12108.8 KOO52989.1 - 0.75 9.7 2.4 1.4 8.8 0.1 2.7 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain UvrD_C PF13361.6 KOO52991.1 - 1.2e-24 87.4 0.0 3.2e-14 53.1 0.0 2.1 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 KOO52991.1 - 0.0033 17.2 0.0 0.0076 16.0 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain EF-hand_6 PF13405.6 KOO52994.1 - 1.1e-23 81.1 4.9 2.6e-06 26.9 0.2 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO52994.1 - 4.8e-22 75.8 7.5 6.1e-06 25.4 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO52994.1 - 4.6e-19 68.6 2.3 1.1e-09 38.6 0.2 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO52994.1 - 6.8e-14 50.6 10.4 0.0048 16.3 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO52994.1 - 2.7e-13 49.5 4.4 3e-07 30.2 0.4 3.5 2 1 1 3 3 3 3 EF-hand domain pair IQ PF00612.27 KOO52994.1 - 0.076 12.8 4.9 3.1 7.8 0.2 2.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif DUF1043 PF06295.12 KOO52994.1 - 2 8.5 7.4 9.8 6.2 7.4 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Filamin PF00630.19 KOO52995.1 - 3.7e-24 85.5 0.0 8e-20 71.6 0.0 2.5 2 0 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO52995.1 - 0.001 19.3 0.0 0.0046 17.2 0.0 2.1 1 0 0 1 1 1 1 Invasin, domain 3 Neurexophilin PF06312.12 KOO52995.1 - 0.035 13.6 0.0 0.065 12.7 0.0 1.3 1 0 0 1 1 1 0 Neurexophilin sCache_like PF16736.5 KOO52995.1 - 0.067 13.3 4.1 4.5 7.4 0.3 2.7 2 0 0 2 2 2 0 Single Cache-like Big_9 PF17963.1 KOO52995.1 - 0.078 13.7 0.7 0.22 12.3 0.1 2.1 2 0 0 2 2 2 0 Bacterial Ig domain PTPlike_phytase PF14566.6 KOO52995.1 - 5.4 7.1 6.5 15 5.7 0.1 2.8 3 0 0 3 3 3 0 Inositol hexakisphosphate Mic1 PF07035.12 KOO52996.1 - 6.7e-34 116.9 0.0 1.3e-33 115.9 0.0 1.4 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Ank_5 PF13857.6 KOO52997.1 - 9.1e-05 22.7 0.1 0.00019 21.7 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO52997.1 - 0.00051 20.4 0.1 0.0014 19.0 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 KOO52997.1 - 0.0023 18.5 0.0 0.0046 17.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO52997.1 - 0.077 13.6 0.2 1 10.1 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat WEMBL PF05701.11 KOO52998.1 - 0.012 14.3 14.7 0.073 11.8 6.6 2.1 2 0 0 2 2 2 0 Weak chloroplast movement under blue light Fez1 PF06818.15 KOO52998.1 - 0.18 12.2 13.3 0.72 10.3 6.8 2.1 2 0 0 2 2 2 0 Fez1 Golgin_A5 PF09787.9 KOO52998.1 - 0.35 10.3 10.8 1.2 8.5 5.3 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 Herpes_UL6 PF01763.16 KOO52998.1 - 0.77 8.2 2.9 1.3 7.5 2.9 1.4 1 0 0 1 1 1 0 Herpesvirus UL6 like End3 PF12761.7 KOO52998.1 - 0.97 9.6 6.8 2.6 8.2 3.2 2.2 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 ADIP PF11559.8 KOO52998.1 - 1.2 9.2 18.1 3.9 7.6 2.1 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 KOO52998.1 - 1.3 7.9 14.6 1.2 8.0 7.0 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 KOO52998.1 - 1.4 8.2 15.8 3.1 7.1 5.1 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DHR10 PF18595.1 KOO52998.1 - 1.6 8.8 25.1 0.27 11.3 11.9 2.4 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF4407 PF14362.6 KOO52998.1 - 1.7 7.9 11.8 0.48 9.7 5.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 KOO52998.1 - 2.6 8.6 20.0 3.6 8.1 2.0 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Atg14 PF10186.9 KOO52998.1 - 3 6.9 11.1 2.8 7.0 4.8 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HrpB7 PF09486.10 KOO52998.1 - 3.2 8.1 27.6 3.7 7.9 3.8 2.5 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) EMP24_GP25L PF01105.24 KOO52998.1 - 4.3 7.2 7.7 5.2 7.0 1.0 2.8 2 1 1 3 3 3 0 emp24/gp25L/p24 family/GOLD KxDL PF10241.9 KOO52998.1 - 5.2 7.4 11.6 3.5 8.0 1.6 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein DUF3037 PF11236.8 KOO52998.1 - 5.9 7.3 6.3 1.9 8.9 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3037) TMF_DNA_bd PF12329.8 KOO52998.1 - 7.9 6.6 12.8 3.7 7.6 2.6 2.8 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding LSM PF01423.22 KOO52999.1 - 9.9e-12 44.4 0.0 1.4e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 LSM domain Lipoprotein_6 PF01441.19 KOO53001.1 - 2.5 8.1 9.1 3.1 7.8 2.6 3.3 3 0 0 3 3 3 0 Lipoprotein Med14 PF08638.11 KOO53001.1 - 7.3 6.0 11.7 0.35 10.3 4.6 2.5 3 0 0 3 3 3 0 Mediator complex subunit MED14 Metallophos PF00149.28 KOO53003.1 - 7e-23 82.2 0.0 9.7e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CAP_GLY PF01302.25 KOO53003.1 - 2e-19 69.3 0.3 3.8e-19 68.5 0.3 1.5 1 0 0 1 1 1 1 CAP-Gly domain Pkinase_Tyr PF07714.17 KOO53005.1 - 0.03 13.6 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase LRR_6 PF13516.6 KOO53006.1 - 3.5e-11 42.2 0.3 0.056 13.5 0.0 4.6 4 0 0 4 4 4 4 Leucine Rich repeat Methyltransf_23 PF13489.6 KOO53007.1 - 5.2e-16 58.9 0.0 7.7e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO53007.1 - 1.2e-12 48.4 0.0 2.4e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO53007.1 - 1.9e-11 44.5 0.0 4.2e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO53007.1 - 1.1e-09 38.8 0.1 4.1e-09 37.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO53007.1 - 1.2e-07 31.7 0.0 1.7e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 KOO53007.1 - 8e-06 26.8 0.0 4.5e-05 24.4 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 KOO53007.1 - 0.00071 19.2 0.0 0.0024 17.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 KOO53007.1 - 0.036 13.4 0.0 0.055 12.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 KOO53007.1 - 0.046 13.3 0.0 0.071 12.7 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Pox_MCEL PF03291.16 KOO53007.1 - 0.18 10.8 0.0 0.98 8.5 0.0 1.9 1 1 0 1 1 1 0 mRNA capping enzyme Thioredoxin PF00085.20 KOO53008.1 - 6.6e-38 128.8 0.0 2.1e-17 63.0 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 KOO53008.1 - 2.4e-16 60.2 0.0 0.00011 22.2 0.0 3.1 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 KOO53008.1 - 7.2e-05 23.2 0.1 0.076 13.5 0.2 3.2 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KOO53008.1 - 0.00076 19.6 0.0 0.8 9.9 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 KOO53008.1 - 0.0029 17.0 0.0 0.49 9.7 0.0 2.2 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_4 PF13462.6 KOO53008.1 - 0.008 16.3 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin PAS_9 PF13426.7 KOO53009.1 - 0.0004 20.6 0.0 0.11 12.7 0.0 2.3 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 KOO53009.1 - 0.014 15.6 0.1 0.77 10.0 0.0 2.4 3 0 0 3 3 3 0 PAS fold Peptidase_M24 PF00557.24 KOO53011.1 - 1.5e-22 80.3 0.7 2e-22 79.9 0.7 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Ter PF05472.11 KOO53011.1 - 0.12 11.4 0.1 0.37 9.8 0.0 1.8 2 0 0 2 2 2 0 DNA replication terminus site-binding protein (Ter protein) Acetyltransf_1 PF00583.25 KOO53013.1 - 3.8e-13 49.7 0.0 7.8e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO53013.1 - 5.3e-08 33.2 0.0 1.4e-07 31.8 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO53013.1 - 7.9e-08 32.3 0.0 1.6e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO53013.1 - 7.8e-06 25.8 0.0 2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 KOO53013.1 - 0.00056 20.1 0.0 0.00088 19.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOO53013.1 - 0.0015 18.6 0.0 0.0037 17.3 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Coa1 PF08695.10 KOO53013.1 - 0.027 14.2 0.1 0.047 13.4 0.1 1.3 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 Acetyltransf_13 PF13880.6 KOO53013.1 - 0.12 12.4 0.1 0.27 11.2 0.1 1.6 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase AAA_lid_11 PF18198.1 KOO53014.1 - 1.2e-30 106.5 0.1 1.6e-30 106.1 0.1 1.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 KOO53015.1 - 0.0024 17.9 0.3 0.003 17.7 0.3 1.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain PRMT5 PF05185.16 KOO53016.1 - 7.3e-63 211.5 0.0 9.2e-63 211.2 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 KOO53016.1 - 9.1e-47 159.2 0.6 1.5e-46 158.5 0.0 1.6 2 0 0 2 2 2 1 PRMT5 oligomerisation domain Methyltransf_25 PF13649.6 KOO53016.1 - 0.00021 22.0 0.0 0.00035 21.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO53016.1 - 0.0025 18.4 0.0 0.0046 17.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Sel1 PF08238.12 KOO53018.1 - 0.00022 21.8 4.6 0.04 14.6 1.2 3.1 2 1 0 2 2 2 2 Sel1 repeat TPR_16 PF13432.6 KOO53018.1 - 0.0032 18.1 5.4 0.0032 18.1 5.4 2.4 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO53018.1 - 0.0068 16.3 0.6 0.0068 16.3 0.6 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOO53018.1 - 0.01 16.4 0.9 0.01 16.4 0.9 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO53018.1 - 0.025 14.7 0.3 0.025 14.7 0.3 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat APOBEC_N PF08210.11 KOO53020.1 - 9.8e-24 84.2 0.1 2.7e-11 43.7 0.0 2.3 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC4 PF18775.1 KOO53020.1 - 4e-06 26.9 0.1 0.31 11.2 0.0 4.1 3 1 0 3 3 3 2 APOBEC4 NAD1 PF18778.1 KOO53020.1 - 0.00046 20.3 0.2 0.67 10.0 0.2 3.8 3 1 0 3 3 3 1 Novel AID APOBEC clade 1 Ank_2 PF12796.7 KOO53021.1 - 4.6e-48 161.7 17.8 3.3e-14 53.2 0.1 5.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO53021.1 - 3.7e-33 113.5 6.0 1.7e-07 31.6 0.1 7.1 5 3 4 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO53021.1 - 2.1e-31 107.6 14.4 4.6e-05 23.6 0.2 8.3 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 KOO53021.1 - 3.5e-19 68.3 31.7 0.1 13.1 0.1 9.2 9 0 0 9 9 9 8 Ankyrin repeat Ank_3 PF13606.6 KOO53021.1 - 4e-19 66.7 8.2 0.54 11.0 0.0 8.7 8 0 0 8 8 8 6 Ankyrin repeat DUF1118 PF06549.12 KOO53021.1 - 3.6e-13 49.8 8.5 1.7e-12 47.7 8.5 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1118) B12D PF06522.11 KOO53021.1 - 0.058 13.2 0.6 35 4.3 0.1 3.4 3 0 0 3 3 3 0 NADH-ubiquinone reductase complex 1 MLRQ subunit PAM2 PF07145.15 KOO53022.1 - 0.069 12.9 1.1 0.16 11.8 1.1 1.7 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Pkinase PF00069.25 KOO53023.1 - 3.1e-63 213.6 0.0 3.8e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53023.1 - 1.3e-33 116.4 0.0 1.6e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO53023.1 - 0.002 17.5 0.0 0.0049 16.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOO53023.1 - 0.0058 16.6 1.4 0.0058 16.6 1.4 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOO53023.1 - 0.036 13.0 0.0 0.055 12.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 KOO53023.1 - 0.064 12.6 0.8 0.24 10.7 0.1 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C2H2 PF00096.26 KOO53024.1 - 4.5e-14 52.0 18.1 1.4e-05 25.3 1.2 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOO53024.1 - 5.1e-13 48.8 25.9 4.5e-05 23.7 1.7 4.1 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOO53024.1 - 2.5e-10 40.3 16.1 0.00093 19.8 0.7 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger CHORD PF04968.12 KOO53024.1 - 0.00016 22.3 15.5 0.35 11.6 1.3 3.1 1 1 2 3 3 3 3 CHORD zf-C2H2_8 PF15909.5 KOO53024.1 - 0.0091 16.3 3.1 0.83 10.0 1.3 2.1 1 1 1 2 2 2 1 C2H2-type zinc ribbon GAGA PF09237.11 KOO53024.1 - 0.023 14.5 0.2 0.09 12.6 0.1 1.9 2 0 0 2 2 2 0 GAGA factor zf-C2H2_aberr PF17017.5 KOO53024.1 - 0.053 13.7 6.5 6.9 6.8 0.3 3.0 1 1 2 3 3 3 0 Aberrant zinc-finger zf-CGNR PF11706.8 KOO53024.1 - 0.086 12.7 6.2 7.2 6.5 2.4 3.3 2 1 0 2 2 2 0 CGNR zinc finger zf-C2HC_2 PF13913.6 KOO53024.1 - 0.12 12.4 8.1 11 6.0 0.2 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type PcF PF09461.10 KOO53024.1 - 0.15 12.4 5.2 4.4 7.7 1.8 2.5 1 1 2 3 3 3 0 Phytotoxin PcF protein Fer2 PF00111.27 KOO53024.1 - 0.16 12.0 6.5 13 5.8 0.1 3.1 3 0 0 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain FANCL_C PF11793.8 KOO53024.1 - 0.17 12.1 6.1 16 5.8 0.2 3.1 1 1 2 3 3 3 0 FANCL C-terminal domain FOXP-CC PF16159.5 KOO53024.1 - 0.65 10.7 7.6 18 6.1 0.3 3.0 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 KOO53024.1 - 0.97 9.5 12.7 0.95 9.5 1.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger MCM_OB PF17207.3 KOO53024.1 - 1.4 8.8 6.0 21 5.0 0.1 2.8 1 1 1 2 2 2 0 MCM OB domain Peptidase_S8 PF00082.22 KOO53026.1 - 3.7e-19 69.1 1.6 6e-19 68.4 1.2 1.6 1 1 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KOO53026.1 - 4.7e-08 32.9 0.1 3.8e-07 30.0 0.0 2.2 2 0 0 2 2 2 1 Proprotein convertase P-domain MRP-L20 PF12824.7 KOO53027.1 - 6.8e-05 23.1 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Bot1p PF12298.8 KOO53027.1 - 0.038 14.2 0.0 0.076 13.2 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein MYCBPAP PF14646.6 KOO53028.1 - 6e-27 94.7 0.1 3.8e-21 75.6 0.0 2.3 2 0 0 2 2 2 2 MYCBP-associated protein family EF-hand_1 PF00036.32 KOO53028.1 - 1.9e-14 52.1 3.0 0.00038 19.8 0.3 4.6 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 KOO53028.1 - 2.2e-13 49.0 1.8 0.0038 17.0 0.0 5.2 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 KOO53028.1 - 8e-12 45.5 0.4 3.9e-07 30.4 0.1 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO53028.1 - 1.5e-09 36.9 3.8 0.0013 18.1 0.0 4.3 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KOO53028.1 - 1.9e-09 37.2 0.1 1e-07 31.7 0.0 4.3 5 1 1 6 6 6 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO53028.1 - 0.0034 17.7 0.1 1.3 9.3 0.0 3.0 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1456 PF07308.13 KOO53028.1 - 0.028 14.7 0.3 43 4.6 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1456) ThylakoidFormat PF11264.8 KOO53028.1 - 0.099 12.3 1.9 0.25 11.0 1.9 1.6 1 0 0 1 1 1 0 Thylakoid formation protein TraB PF01963.17 KOO53029.1 - 0.00042 20.3 0.7 0.0012 18.7 0.1 1.9 2 1 0 2 2 2 1 TraB family ADIP PF11559.8 KOO53030.1 - 0.0057 16.8 6.4 0.0057 16.8 6.4 3.8 2 1 2 4 4 4 1 Afadin- and alpha -actinin-Binding Holin_BhlA PF10960.8 KOO53030.1 - 1.4 8.9 11.7 1.1 9.3 0.2 3.2 3 1 0 3 3 3 0 BhlA holin family DUF1154 PF06631.11 KOO53030.1 - 2.1 8.4 9.1 5 7.2 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1154) DUF3811 PF11656.8 KOO53031.1 - 0.012 16.0 7.2 0.013 15.9 7.2 1.0 1 0 0 1 1 1 0 YjbD family (DUF3811) XhlA PF10779.9 KOO53031.1 - 0.68 10.2 5.1 0.64 10.3 4.0 1.5 1 1 1 2 2 2 0 Haemolysin XhlA TSA PF03249.13 KOO53031.1 - 1.9 7.2 6.5 2.2 7.0 6.5 1.0 1 0 0 1 1 1 0 Type specific antigen Ion_trans PF00520.31 KOO53032.1 - 1.1e-17 64.1 7.4 1.6e-17 63.6 7.4 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOO53032.1 - 6.2e-06 25.2 3.1 9.7e-06 24.5 3.1 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans_2 PF07885.16 KOO53032.1 - 0.2 11.6 4.1 0.49 10.4 4.1 1.6 1 0 0 1 1 1 0 Ion channel DUF2206 PF09971.9 KOO53032.1 - 1.1 7.9 3.1 1.7 7.3 3.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) Kinesin PF00225.23 KOO53033.1 - 1.5e-106 356.1 0.0 2e-106 355.7 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO53033.1 - 1.2e-21 77.2 0.0 2.4e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding bZIP_2 PF07716.15 KOO53033.1 - 1.1 9.4 4.9 5.4 7.2 0.9 3.1 3 0 0 3 3 3 0 Basic region leucine zipper Acyl-CoA_dh_M PF02770.19 KOO53035.1 - 0.003 17.7 0.0 0.01 16.0 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Hpt PF01627.23 KOO53036.1 - 0.0057 16.9 0.0 0.0089 16.3 0.0 1.3 1 0 0 1 1 1 1 Hpt domain rve_2 PF13333.6 KOO53036.1 - 0.032 14.4 0.0 0.061 13.5 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain Pkinase_Tyr PF07714.17 KOO53038.1 - 3.8e-09 36.2 0.0 8.4e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO53038.1 - 1.9e-08 34.0 0.0 4.4e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain CRC_subunit PF08624.10 KOO53038.1 - 0.065 13.7 0.1 0.42 11.0 0.0 2.1 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit CASP_C PF08172.12 KOO53038.1 - 1.6 8.0 7.8 0.25 10.7 4.0 1.5 2 0 0 2 2 2 0 CASP C terminal Fib_alpha PF08702.10 KOO53039.1 - 0.2 11.9 5.3 0.67 10.1 0.8 2.9 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.9 KOO53039.1 - 0.23 11.5 26.3 0.16 12.0 10.0 4.1 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sin_N PF04801.13 KOO53039.1 - 0.78 8.9 14.9 1 8.5 14.9 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region XPC-binding PF09280.11 KOO53039.1 - 1.1 9.0 5.6 23 4.8 0.7 3.6 4 0 0 4 4 4 0 XPC-binding domain DUF1664 PF07889.12 KOO53039.1 - 1.9 8.6 8.0 12 6.0 0.5 3.7 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 KOO53039.1 - 3.6 7.3 15.9 4.9 6.9 1.2 3.3 1 1 1 3 3 3 0 Domain of unknown function (DUF4201) Golgin_A5 PF09787.9 KOO53039.1 - 4.7 6.6 23.8 0.16 11.4 13.5 2.7 1 1 2 3 3 3 0 Golgin subfamily A member 5 DTHCT PF08070.11 KOO53040.1 - 3.7 8.3 31.2 9.5 7.0 17.0 2.3 1 1 1 2 2 2 0 DTHCT (NUC029) region TIG PF01833.24 KOO53041.1 - 1.9e-29 101.6 1.3 1.1e-06 28.6 0.1 6.2 5 1 0 5 5 5 5 IPT/TIG domain TIG_plexin PF17960.1 KOO53041.1 - 6.1e-07 29.3 0.0 0.11 12.4 0.0 4.3 4 0 0 4 4 4 2 TIG domain 2OG-FeII_Oxy_3 PF13640.6 KOO53043.1 - 8.3e-15 55.5 0.0 1.2e-14 55.0 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOO53043.1 - 0.0052 17.2 0.0 0.0095 16.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2838 PF10998.8 KOO53044.1 - 1.5e-38 131.4 8.6 2.4e-38 130.8 8.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2838) Popeye PF04831.13 KOO53044.1 - 3.9 7.7 6.0 7 6.8 6.0 1.3 1 0 0 1 1 1 0 Popeye protein conserved region Galactosyl_T PF01762.21 KOO53045.1 - 1.1e-07 31.9 0.0 2.5e-07 30.7 0.0 1.5 2 0 0 2 2 2 1 Galactosyltransferase TPR_2 PF07719.17 KOO53046.1 - 6.3e-13 47.8 32.4 0.0053 16.8 0.6 8.9 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53046.1 - 8.4e-10 38.1 26.7 0.017 14.9 0.2 7.8 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53046.1 - 6.5e-07 29.5 39.1 0.0079 16.5 1.7 8.8 9 3 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53046.1 - 1.1e-05 25.2 15.6 0.18 12.1 0.1 7.8 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO53046.1 - 0.00013 21.7 16.7 0.041 13.8 3.0 5.3 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO53046.1 - 0.00019 21.9 33.3 0.28 11.7 1.1 8.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO53046.1 - 0.0015 18.8 1.9 36 5.0 0.1 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO53046.1 - 0.0032 17.4 22.6 0.063 13.3 0.6 7.7 10 1 0 10 10 9 2 Tetratricopeptide repeat DUF3808 PF10300.9 KOO53046.1 - 0.0077 15.0 1.3 0.014 14.2 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_16 PF13432.6 KOO53046.1 - 0.011 16.4 4.1 0.011 16.4 4.1 7.9 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53046.1 - 0.18 12.7 43.1 0.4 11.6 1.8 9.3 9 3 2 11 11 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53046.1 - 0.25 11.0 8.1 1.3 8.8 0.0 5.4 7 0 0 7 7 7 0 TPR repeat Fis1_TPR_C PF14853.6 KOO53046.1 - 0.36 10.9 5.4 2.3 8.4 0.7 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 KOO53046.1 - 0.91 10.3 26.1 0.18 12.5 1.8 7.6 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_21 PF09976.9 KOO53046.1 - 8.3 6.1 14.2 0.12 12.1 4.8 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain Glyco_transf_34 PF05637.12 KOO53047.1 - 3.5e-08 33.5 0.1 1.4e-07 31.5 0.1 1.8 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DEAD PF00270.29 KOO53048.1 - 1.6e-45 155.1 0.0 2.8e-45 154.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO53048.1 - 5.7e-29 100.7 0.0 4e-28 98.0 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO53048.1 - 7.6e-06 26.0 0.0 1.5e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 KOO53048.1 - 0.0068 15.2 0.2 0.14 10.9 0.0 2.7 1 1 2 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 KOO53048.1 - 0.041 13.2 0.0 0.041 13.2 0.0 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Phage_integrase PF00589.22 KOO53048.1 - 0.042 13.6 0.4 6.1 6.6 0.0 2.4 2 0 0 2 2 2 0 Phage integrase family AAA_22 PF13401.6 KOO53048.1 - 0.059 13.6 0.2 0.31 11.3 0.2 2.3 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 KOO53049.1 - 7.3e-30 104.0 0.7 4.8e-28 98.0 0.7 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KOO53049.1 - 6e-18 64.9 1.0 1e-17 64.2 0.2 1.8 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 KOO53049.1 - 1.4e-09 38.0 0.0 2.9e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 KOO53049.1 - 5.6e-05 22.8 0.0 9.4e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Ras family PduV-EutP PF10662.9 KOO53049.1 - 0.00013 21.7 0.1 0.00052 19.8 0.1 2.0 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 KOO53049.1 - 0.0003 21.0 0.0 0.0005 20.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 KOO53049.1 - 0.0004 20.0 0.1 0.0021 17.6 0.0 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 KOO53049.1 - 0.0012 18.3 0.0 0.002 17.6 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit IF2_N PF04760.15 KOO53049.1 - 0.0083 15.9 0.1 1.5 8.7 0.0 2.9 3 0 0 3 3 3 1 Translation initiation factor IF-2, N-terminal region DUF460 PF04312.13 KOO53049.1 - 0.032 13.9 0.1 0.18 11.5 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF460) Dynamin_N PF00350.23 KOO53049.1 - 0.1 12.6 0.0 16 5.5 0.0 2.4 1 1 1 2 2 2 0 Dynamin family TPR_2 PF07719.17 KOO53050.1 - 1.8e-07 30.8 1.9 0.003 17.5 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53050.1 - 2.2e-07 30.5 0.3 0.0017 18.4 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOO53050.1 - 5.7e-07 29.1 1.3 0.044 13.8 0.0 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO53050.1 - 1.5e-05 25.4 8.1 0.00022 21.7 1.1 3.5 2 2 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO53050.1 - 2.1e-05 25.0 7.3 0.00026 21.6 0.8 5.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53050.1 - 0.0012 18.6 1.9 0.0041 16.9 0.0 2.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO53050.1 - 0.0015 18.7 0.6 0.0015 18.7 0.6 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53050.1 - 0.0023 18.6 25.4 0.065 14.1 0.2 6.5 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53050.1 - 0.0062 16.2 0.0 0.25 11.1 0.0 3.0 2 1 0 2 2 2 1 TPR repeat TPR_20 PF14561.6 KOO53050.1 - 0.044 14.1 5.4 0.37 11.1 0.2 3.7 2 2 2 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 KOO53050.1 - 0.046 13.4 0.3 3.1 7.5 0.0 2.5 1 1 1 2 2 2 0 26S proteasome subunit RPN7 TPR_12 PF13424.6 KOO53050.1 - 0.051 13.9 20.1 0.053 13.8 0.0 5.1 6 1 0 6 6 6 0 Tetratricopeptide repeat SPO22 PF08631.10 KOO53050.1 - 0.067 12.7 1.3 0.14 11.6 0.8 1.8 1 1 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like TPR_6 PF13174.6 KOO53050.1 - 0.093 13.4 4.1 3.6 8.4 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOO53051.1 - 4.7e-11 41.9 18.3 0.00017 21.4 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53051.1 - 7.3e-09 35.1 0.1 8.4e-05 22.2 0.0 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat CS PF04969.16 KOO53051.1 - 3.6e-08 34.3 0.0 6.1e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 CS domain TPR_8 PF13181.6 KOO53051.1 - 5e-08 32.5 0.4 0.013 15.6 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53051.1 - 2.7e-07 30.1 0.7 0.00059 19.5 0.1 3.0 1 1 1 2 2 2 2 TPR repeat TPR_17 PF13431.6 KOO53051.1 - 8.6e-05 22.7 3.0 1.9 9.0 0.0 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO53051.1 - 0.00012 22.6 1.2 0.00012 22.6 1.2 4.5 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53051.1 - 0.00039 21.0 11.9 0.0025 18.5 0.8 4.2 3 1 2 5 5 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO53051.1 - 0.0028 18.1 6.3 3.1 8.4 0.0 3.2 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53051.1 - 0.017 15.4 0.6 0.017 15.4 0.6 3.6 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO53051.1 - 0.04 13.8 2.6 7.3 6.6 0.2 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO53051.1 - 0.39 11.0 7.4 0.83 9.9 0.2 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KOO53051.1 - 0.49 11.1 0.0 0.49 11.1 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO53051.1 - 0.66 10.2 9.8 0.042 14.0 2.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat GARP PF16731.5 KOO53051.1 - 8.2 6.1 15.2 8.3 6.0 13.3 1.9 1 1 1 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Alpha_kinase PF02816.18 KOO53052.1 - 1.3e-28 100.3 0.1 3.1e-27 95.9 0.0 2.6 2 1 0 2 2 2 1 Alpha-kinase family Ank_2 PF12796.7 KOO53052.1 - 5.9e-14 52.4 0.0 1.2e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOO53052.1 - 2.3e-09 37.3 0.0 0.0026 18.1 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KOO53052.1 - 7e-09 35.2 0.0 0.0017 18.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KOO53052.1 - 8.7e-08 32.3 0.2 0.006 16.9 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO53052.1 - 2.7e-07 31.0 0.0 0.026 15.1 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Arc_PepC PF06819.11 KOO53052.1 - 0.19 11.9 0.4 0.42 10.8 0.4 1.5 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain SAP PF02037.27 KOO53052.1 - 0.21 11.4 1.8 0.61 9.9 0.1 2.6 2 0 0 2 2 2 0 SAP domain NifU PF01106.17 KOO53053.1 - 3.9e-09 36.5 0.1 1.1e-06 28.7 0.0 2.3 2 1 0 2 2 2 2 NifU-like domain RPN1_RPN2_N PF17781.1 KOO53054.1 - 7.2e-115 383.6 0.0 8.9e-115 383.3 0.0 1.1 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain PC_rep PF01851.22 KOO53054.1 - 7.8e-21 73.4 12.8 0.00014 22.1 0.1 7.2 8 0 0 8 8 8 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 KOO53054.1 - 4.5e-07 30.2 4.4 0.018 15.4 0.1 4.4 3 2 0 3 3 3 3 HEAT repeats T3SS_ExsE PF18286.1 KOO53054.1 - 0.1 12.6 0.0 0.41 10.6 0.0 2.0 1 0 0 1 1 1 0 Type III secretion system ExsE MitMem_reg PF13012.6 KOO53056.1 - 1.6e-34 118.7 0.5 2.8e-34 117.9 0.5 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 KOO53056.1 - 1.3e-29 102.5 0.0 2.7e-29 101.6 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CwfJ_C_1 PF04677.15 KOO53057.1 - 2.2e-20 72.8 0.0 2.9e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 KOO53057.1 - 1.1e-05 26.2 0.0 2.5e-05 25.1 0.0 1.6 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 ARID PF01388.21 KOO53058.1 - 7.7e-21 74.6 0.1 1.3e-20 73.8 0.1 1.3 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 KOO53058.1 - 1.4e-10 41.0 0.0 2.6e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 jmjN domain PCI PF01399.27 KOO53059.1 - 7.5e-10 39.3 0.1 4e-09 36.9 0.0 2.2 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 KOO53059.1 - 0.068 13.3 0.3 0.35 11.1 0.3 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53059.1 - 0.093 13.0 1.4 0.28 11.5 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53059.1 - 2 8.3 4.1 0.82 9.6 0.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DmsC PF04976.12 KOO53059.1 - 5 6.5 7.3 0.25 10.8 0.9 2.1 2 1 1 3 3 3 0 DMSO reductase anchor subunit (DmsC) PDZ_6 PF17820.1 KOO53060.1 - 2.1e-20 72.3 3.5 0.0015 18.3 0.1 4.7 4 0 0 4 4 4 4 PDZ domain PDZ PF00595.24 KOO53060.1 - 1.1e-18 67.3 0.8 0.006 16.9 0.0 4.5 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 KOO53060.1 - 5.3e-14 52.3 6.3 0.068 13.5 0.0 4.5 4 0 0 4 4 4 4 PDZ domain FAA_hydrolase_N PF09298.11 KOO53060.1 - 4e-07 30.2 0.4 5.8 7.2 0.0 4.5 4 0 0 4 4 4 4 Fumarylacetoacetase N-terminal DUF3394 PF11874.8 KOO53060.1 - 5.2e-07 29.5 0.0 3.5 7.3 0.0 4.4 4 0 0 4 4 4 3 Domain of unknown function (DUF3394) DUF1948 PF09185.10 KOO53060.1 - 0.00068 19.5 0.0 11 5.8 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF1948) zf-LSD1 PF06943.12 KOO53060.1 - 0.02 14.8 0.5 85 3.1 0.0 3.9 4 0 0 4 4 4 0 LSD1 zinc finger RVT_2 PF07727.14 KOO53061.1 - 2e-05 24.4 0.1 4.4e-05 23.2 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DSPn PF14671.6 KOO53062.1 - 2.8e-41 141.2 0.1 1.6e-40 138.8 0.0 2.0 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 KOO53062.1 - 1.7e-10 40.8 0.0 3.6e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KOO53062.1 - 1e-05 25.7 0.0 1.8e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 KOO53062.1 - 1.4e-05 24.8 0.0 2.9e-05 23.7 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KOO53062.1 - 0.0034 17.4 0.0 0.0055 16.7 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family RNB PF00773.19 KOO53063.1 - 0.0067 15.8 0.8 0.0088 15.4 0.8 1.2 1 0 0 1 1 1 1 RNB domain Pyr_redox_2 PF07992.14 KOO53065.1 - 1.2e-19 70.7 0.0 1.5e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOO53065.1 - 7.6e-05 23.2 0.0 0.00013 22.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF3761 PF12587.8 KOO53066.1 - 0.12 12.8 0.4 12 6.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) PKcGMP_CC PF16808.5 KOO53067.1 - 3.3e-05 23.6 30.1 7.7 6.5 0.3 9.6 9 0 0 9 9 9 5 Coiled-coil N-terminus of cGMP-dependent protein kinase Pox_A_type_inc PF04508.12 KOO53067.1 - 0.0079 16.0 10.7 5.7 7.0 0.1 6.5 7 0 0 7 7 7 1 Viral A-type inclusion protein repeat SAB PF04382.13 KOO53067.1 - 0.024 14.7 7.4 7.1 6.8 0.1 5.6 4 1 3 7 7 7 0 SAB domain Med9 PF07544.13 KOO53067.1 - 0.027 14.6 1.2 0.027 14.6 1.2 6.1 4 2 1 6 6 6 0 RNA polymerase II transcription mediator complex subunit 9 Ubiquitin_3 PF14836.6 KOO53068.1 - 0.011 15.7 0.7 0.15 12.1 0.1 2.2 1 1 0 2 2 2 0 Ubiquitin-like domain DUF2175 PF09943.9 KOO53068.1 - 0.57 10.5 5.2 3 8.2 0.9 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Nucleotid_trans PF03407.16 KOO53070.1 - 7.2e-10 39.2 0.0 1e-09 38.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Laminin_G_3 PF13385.6 KOO53071.1 - 9.8e-11 42.0 0.0 1.1e-10 41.8 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.17 KOO53071.1 - 0.19 11.4 0.0 0.24 11.0 0.0 1.1 1 0 0 1 1 1 0 Pentaxin family Ribosomal_L14 PF00238.19 KOO53072.1 - 4.9e-41 139.6 1.5 6.1e-41 139.3 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Acetyltransf_1 PF00583.25 KOO53073.1 - 1.4e-07 31.7 0.0 2.3e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOO53073.1 - 8.2e-07 29.4 0.0 1.4e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOO53073.1 - 1.4e-05 25.1 0.0 2.1e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOO53073.1 - 0.048 13.6 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 FR47-like protein YaeQ PF07152.12 KOO53073.1 - 0.095 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 YaeQ protein Abhydrolase_6 PF12697.7 KOO53075.1 - 2.3e-09 38.2 4.8 2.3e-09 38.2 4.8 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOO53075.1 - 6.6e-06 26.0 0.4 1.6e-05 24.7 0.2 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold EF-hand_1 PF00036.32 KOO53076.1 - 2.8e-13 48.4 0.3 3.3e-06 26.3 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO53076.1 - 3.4e-13 48.3 0.0 1.1e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOO53076.1 - 2.7e-12 46.9 0.0 4.6e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO53076.1 - 9.6e-09 34.4 0.5 2.2e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO53076.1 - 6.2e-07 29.2 0.0 0.025 14.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair Caleosin PF05042.13 KOO53076.1 - 0.014 15.4 0.0 2.6 7.9 0.1 2.1 1 1 1 2 2 2 0 Caleosin related protein DUF772 PF05598.11 KOO53076.1 - 0.15 12.1 0.1 0.38 10.8 0.1 1.7 1 1 0 1 1 1 0 Transposase domain (DUF772) Ribosomal_L23 PF00276.20 KOO53079.1 - 7.1e-14 51.9 0.0 1e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 Ank_2 PF12796.7 KOO53080.1 - 7.8e-38 128.9 11.5 2.5e-15 56.8 1.5 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO53080.1 - 3.9e-31 107.0 17.4 1.6e-07 31.7 0.1 5.8 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO53080.1 - 1.2e-22 79.6 13.7 1.3e-06 28.6 0.8 6.0 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 KOO53080.1 - 4.2e-21 74.4 24.7 0.0041 17.5 0.2 7.4 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 KOO53080.1 - 3.4e-12 45.4 16.3 0.041 14.4 0.1 7.8 8 0 0 8 8 8 3 Ankyrin repeat SR1P PF13790.6 KOO53080.1 - 0.00061 19.8 0.5 13 5.9 0.0 4.4 5 0 0 5 5 5 2 SR1 protein Prok-RING_1 PF14446.6 KOO53080.1 - 0.027 14.4 10.5 4.5 7.3 0.1 5.1 6 0 0 6 6 6 0 Prokaryotic RING finger family 1 SpoIIIAH PF12685.7 KOO53080.1 - 0.32 10.8 5.9 0.49 10.2 5.9 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Phospholip_A2_2 PF05826.12 KOO53080.1 - 0.65 10.3 7.0 13 6.1 0.4 3.2 1 1 4 5 5 5 0 Phospholipase A2 PPR_2 PF13041.6 KOO53081.1 - 4.8e-64 212.4 0.2 1e-11 44.8 0.0 7.0 1 1 6 7 7 7 7 PPR repeat family PPR_3 PF13812.6 KOO53081.1 - 5.7e-45 151.2 0.0 7.4e-11 42.0 0.0 4.4 2 1 3 5 5 5 5 Pentatricopeptide repeat domain PPR PF01535.20 KOO53081.1 - 9.2e-44 144.7 4.9 3.8e-05 23.6 0.0 8.2 8 0 0 8 8 8 7 PPR repeat PPR_1 PF12854.7 KOO53081.1 - 1.2e-43 146.4 0.0 2.9e-05 23.7 0.0 8.3 8 0 0 8 8 8 7 PPR repeat PCIF1_WW PF12237.8 KOO53081.1 - 5e-30 104.4 0.7 1.1e-29 103.2 0.7 1.5 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain PPR_long PF17177.4 KOO53081.1 - 4.4e-24 85.0 0.1 6.3e-13 48.6 0.0 2.3 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP Dev_Cell_Death PF10539.9 KOO53081.1 - 4.1e-13 49.3 0.0 7.1e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Development and cell death domain ANAPC3 PF12895.7 KOO53081.1 - 0.00036 20.7 0.1 0.009 16.2 0.0 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KOO53081.1 - 0.001 19.0 3.3 38 4.6 0.0 6.6 7 0 0 7 7 6 0 Tetratricopeptide repeat Clathrin PF00637.20 KOO53081.1 - 0.0011 18.8 0.0 0.34 10.8 0.0 3.5 3 1 2 5 5 4 2 Region in Clathrin and VPS MRP-S27 PF10037.9 KOO53081.1 - 0.0098 14.8 0.0 2.1 7.1 0.0 2.7 1 1 2 3 3 3 1 Mitochondrial 28S ribosomal protein S27 TPR_19 PF14559.6 KOO53081.1 - 0.043 14.3 2.7 0.72 10.4 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat Ebola_NP PF05505.12 KOO53081.1 - 0.094 11.0 0.1 0.61 8.3 0.0 2.2 2 1 1 3 3 3 0 Ebola nucleoprotein TIR_2 PF13676.6 KOO53083.1 - 9.3e-06 26.2 0.0 2.6e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 TIR domain Ribosomal_L13e PF01294.18 KOO53083.1 - 1.6e-05 24.8 18.9 1.7 8.5 0.1 8.4 3 2 5 8 8 8 4 Ribosomal protein L13e Cna_B PF05738.13 KOO53083.1 - 0.0012 19.4 6.1 5.6 7.6 0.1 4.5 4 0 0 4 4 4 2 Cna protein B-type domain SinI PF08671.10 KOO53083.1 - 0.0069 16.2 1.9 31 4.5 0.0 5.6 5 1 2 7 7 7 0 Anti-repressor SinI MerR_1 PF13411.6 KOO53083.1 - 0.013 15.5 0.0 46 4.2 0.0 5.4 5 1 1 6 6 6 0 MerR HTH family regulatory protein RPAP1_C PF08620.10 KOO53083.1 - 0.86 9.8 13.6 60 3.9 0.0 7.4 4 2 4 8 8 8 0 RPAP1-like, C-terminal ZapB PF06005.12 KOO53084.1 - 0.27 11.7 2.7 17 5.9 0.1 3.1 3 0 0 3 3 3 0 Cell division protein ZapB Syntaphilin PF15290.6 KOO53084.1 - 0.33 10.6 0.9 0.55 9.8 0.9 1.3 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp bZIP_1 PF00170.21 KOO53084.1 - 3.5 7.8 7.8 18 5.5 2.9 2.4 2 0 0 2 2 2 0 bZIP transcription factor GAS PF13851.6 KOO53084.1 - 9.6 5.5 6.6 9.4 5.5 0.2 2.9 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding TMF_DNA_bd PF12329.8 KOO53084.1 - 9.7 6.3 11.2 4.4 7.4 0.0 3.4 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding FHA PF00498.26 KOO53085.1 - 8e-17 61.4 0.4 1.2e-16 60.8 0.4 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO53085.1 - 3.2e-11 43.4 0.0 6.7e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Jnk-SapK_ap_N PF09744.9 KOO53085.1 - 0.024 14.9 1.3 0.045 14.0 1.3 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 OmpH PF03938.14 KOO53085.1 - 0.032 14.6 3.9 0.049 14.0 3.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) APG6_N PF17675.1 KOO53085.1 - 0.075 13.6 8.4 0.12 12.9 8.4 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region H-kinase_dim PF02895.14 KOO53085.1 - 0.26 11.7 1.1 0.49 10.8 1.1 1.4 1 0 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain ZapB PF06005.12 KOO53085.1 - 3.6 8.1 8.3 6.8 7.2 8.3 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DUF4140 PF13600.6 KOO53085.1 - 8.5 6.9 7.0 55 4.3 6.6 2.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) RNase_H2-Ydr279 PF09468.10 KOO53086.1 - 9.2e-11 42.2 0.0 2.4e-10 40.9 0.0 1.6 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 KOO53086.1 - 0.00022 21.4 0.0 0.00044 20.5 0.0 1.5 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain PDZ_6 PF17820.1 KOO53087.1 - 1.6e-44 149.6 14.8 8.8e-08 31.9 0.2 8.9 8 0 0 8 8 8 7 PDZ domain PDZ PF00595.24 KOO53087.1 - 1.2e-38 131.3 1.2 9e-06 26.0 0.0 8.2 7 1 1 8 8 8 7 PDZ domain PDZ_2 PF13180.6 KOO53087.1 - 7.4e-36 122.3 2.4 3.9e-05 23.9 0.0 8.5 5 2 3 8 8 8 7 PDZ domain EF-hand_5 PF13202.6 KOO53087.1 - 7e-19 66.4 2.2 0.00039 19.8 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO53087.1 - 3.8e-18 63.8 0.0 0.003 17.4 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO53087.1 - 1.6e-17 61.6 0.0 0.0032 16.9 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO53087.1 - 3.2e-12 46.7 0.0 0.00039 20.8 0.0 3.7 2 2 1 3 3 3 3 EF-hand domain pair Tricorn_PDZ PF14685.6 KOO53087.1 - 3.1e-08 33.5 0.1 0.077 13.0 0.0 5.2 5 0 0 5 5 5 2 Tricorn protease PDZ domain EF-hand_8 PF13833.6 KOO53087.1 - 0.00035 20.4 0.3 4.1 7.3 0.0 4.1 4 0 0 4 4 4 2 EF-hand domain pair DUF3640 PF12342.8 KOO53087.1 - 0.022 14.5 0.5 9.5 6.1 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3640) WD40 PF00400.32 KOO53087.1 - 0.086 13.7 5.2 0.17 12.8 0.3 2.8 2 0 0 2 2 2 0 WD domain, G-beta repeat Rieske PF00355.26 KOO53088.1 - 3.7e-15 55.6 0.0 7.4e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PaO PF08417.12 KOO53088.1 - 1.1e-11 44.7 0.3 2.7e-11 43.4 0.1 1.7 2 0 0 2 2 2 1 Pheophorbide a oxygenase DUF935 PF06074.12 KOO53089.1 - 1.8 7.2 24.8 0.19 10.5 14.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF935) CCDC85 PF10226.9 KOO53090.1 - 0.0055 16.4 1.0 0.018 14.7 0.0 1.9 2 0 0 2 2 2 1 CCDC85 family MCU PF04678.13 KOO53090.1 - 1.5 8.9 6.4 1.9 8.5 6.4 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter PLRV_ORF5 PF01690.17 KOO53090.1 - 3.3 6.3 0.0 3.3 6.3 0.0 2.3 3 0 0 3 3 3 0 Potato leaf roll virus readthrough protein GAS PF13851.6 KOO53091.1 - 1.8 7.9 17.1 0.39 10.0 8.1 2.4 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding YabA PF06156.13 KOO53091.1 - 4.3 8.0 9.1 6.3 7.5 3.6 2.5 2 0 0 2 2 2 0 Initiation control protein YabA Kri1 PF05178.12 KOO53091.1 - 5.2 7.7 10.7 1.1 9.8 2.7 2.5 2 1 0 2 2 2 0 KRI1-like family Spc7 PF08317.11 KOO53091.1 - 6.9 5.4 18.1 4.9 5.9 6.0 2.7 2 1 0 2 2 2 0 Spc7 kinetochore protein MFS_1 PF07690.16 KOO53092.1 - 2.3e-14 53.1 47.5 6.1e-09 35.3 23.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily dCMP_cyt_deam_1 PF00383.23 KOO53093.1 - 5.8e-24 83.9 0.1 1.5e-23 82.6 0.0 1.6 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KOO53093.1 - 9.6e-12 44.8 0.0 1.5e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase PTCB-BRCT PF12738.7 KOO53095.1 - 2.8e-25 88.1 0.0 5.2e-11 42.3 0.0 3.2 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.26 KOO53095.1 - 6e-21 74.6 0.0 7e-08 32.7 0.0 3.1 3 0 0 3 3 3 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KOO53095.1 - 1.5e-10 41.4 0.0 1.3e-05 25.5 0.0 2.7 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 KOO53095.1 - 0.0012 18.6 0.0 0.35 10.8 0.0 2.2 2 0 0 2 2 2 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 KOO53095.1 - 0.0084 16.4 0.0 4.1 7.8 0.0 2.7 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 KOO53095.1 - 0.013 15.6 0.0 0.93 9.6 0.0 2.3 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain SR-25 PF10500.9 KOO53096.1 - 0.3 10.6 21.8 0.38 10.3 21.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SelP_N PF04592.14 KOO53096.1 - 3 7.2 14.8 3 7.2 14.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RNA_polI_A34 PF08208.11 KOO53096.1 - 4.8 7.2 23.1 5.6 7.0 23.1 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Chloroa_b-bind PF00504.21 KOO53097.1 - 3.1e-37 128.6 0.0 3.7e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Dor1 PF04124.12 KOO53098.1 - 3.2e-45 154.3 0.0 4.3e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Dor1-like family SPA PF08616.10 KOO53099.1 - 1.7e-26 92.4 0.0 2.6e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 KOO53099.1 - 2.9e-17 63.4 0.0 5.7e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 KOO53099.1 - 6.1e-11 41.6 0.0 0.0083 14.9 0.0 3.2 2 1 1 3 3 3 3 Transport protein Avl9 DUF2347 PF09804.9 KOO53099.1 - 2.2e-08 34.0 0.0 9.7e-07 28.6 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) HEAT_2 PF13646.6 KOO53099.1 - 0.16 12.4 1.2 4.5 7.7 0.1 2.4 2 0 0 2 2 2 0 HEAT repeats zf-H2C2_2 PF13465.6 KOO53100.1 - 1.9e-19 69.1 23.5 5.2e-05 23.5 0.1 5.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 KOO53100.1 - 2.4e-15 56.0 23.3 0.00057 20.2 1.1 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOO53100.1 - 1.1e-05 25.8 22.9 0.56 11.2 1.0 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KOO53100.1 - 0.014 15.1 1.8 0.014 15.1 1.8 3.6 2 2 0 2 2 2 0 C2H2-type zinc-finger domain FOXP-CC PF16159.5 KOO53100.1 - 2.8 8.6 10.9 79 4.0 0.2 4.1 1 1 3 4 4 4 0 FOXP coiled-coil domain Chromo PF00385.24 KOO53104.1 - 2.6e-09 36.9 2.8 1.9e-08 34.1 1.2 2.2 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Methyltransf_21 PF05050.12 KOO53107.1 - 0.0076 16.3 0.0 0.0099 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain RRM_1 PF00076.22 KOO53108.1 - 2.5e-06 27.2 0.0 0.00038 20.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TIR_2 PF13676.6 KOO53109.1 - 5.7e-05 23.7 0.0 5.7e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 KOO53109.1 - 0.0024 17.7 0.0 0.0031 17.3 0.0 1.1 1 0 0 1 1 1 1 TIR domain tRNA_int_endo PF01974.17 KOO53109.1 - 0.078 13.1 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 tRNA intron endonuclease, catalytic C-terminal domain BRCA-2_OB1 PF09103.10 KOO53109.1 - 0.094 12.7 0.0 0.15 12.0 0.0 1.4 1 1 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Radical_SAM PF04055.21 KOO53110.1 - 3.1e-18 66.7 0.0 5.6e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 KOO53110.1 - 0.00058 20.0 0.0 0.001 19.2 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain SPOR PF05036.13 KOO53110.1 - 0.008 16.5 3.4 19 5.7 0.0 3.8 4 0 0 4 4 4 2 Sporulation related domain Fer4_12 PF13353.6 KOO53110.1 - 0.013 15.8 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S single cluster domain Acetyltransf_7 PF13508.7 KOO53111.1 - 0.048 14.1 0.0 0.085 13.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain EF-hand_1 PF00036.32 KOO53112.1 - 4.6e-12 44.6 2.1 8e-07 28.2 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO53112.1 - 1.3e-10 41.5 0.8 2.4e-10 40.7 0.8 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO53112.1 - 6.5e-09 35.0 1.0 3.2e-06 26.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO53112.1 - 1.8e-06 27.2 2.0 0.00035 19.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO53112.1 - 1.7e-05 24.5 1.6 0.00071 19.4 0.7 2.6 2 1 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO53112.1 - 0.0073 16.6 0.0 0.19 12.1 0.0 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOO53112.1 - 0.022 14.7 0.2 1.6 8.7 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand C2 PF00168.30 KOO53113.1 - 3.4e-12 46.6 0.0 6.3e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain Lipoxygenase PF00305.19 KOO53113.1 - 6.1e-09 34.9 0.0 2.2e-08 33.1 0.0 1.8 2 0 0 2 2 2 1 Lipoxygenase Phage_integrase PF00589.22 KOO53114.1 - 2.7e-06 27.3 0.0 1.9e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Phage integrase family TPT PF03151.16 KOO53115.1 - 2.6e-05 23.7 18.8 4.1e-05 23.1 18.8 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family TPT PF03151.16 KOO53116.1 - 3.2e-08 33.3 4.1 4.1e-08 32.9 4.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO53116.1 - 6.5e-05 23.1 16.4 6.5e-05 23.1 16.4 2.2 2 1 1 3 3 3 1 EamA-like transporter family DUF423 PF04241.15 KOO53116.1 - 0.031 14.5 3.8 3.2 8.0 0.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF423) YabA PF06156.13 KOO53118.1 - 0.014 16.0 0.6 0.014 16.0 0.6 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Spc7 PF08317.11 KOO53118.1 - 7.1 5.4 21.7 1.1 8.0 3.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4281 PF14108.6 KOO53121.1 - 1.9e-29 102.6 0.8 4.7e-29 101.3 0.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4281) Ion_trans PF00520.31 KOO53121.1 - 2.3e-23 82.7 5.7 2.3e-23 82.7 5.7 1.9 2 0 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.16 KOO53121.1 - 6.9e-07 29.1 1.3 6.9e-07 29.1 1.3 2.0 2 0 0 2 2 2 1 Ion channel F-box-like PF12937.7 KOO53122.1 - 0.065 13.1 0.3 0.12 12.3 0.3 1.5 1 1 0 1 1 1 0 F-box-like EF-hand_6 PF13405.6 KOO53123.1 - 3.3e-18 64.0 6.6 0.00056 19.6 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KOO53123.1 - 1.5e-15 56.7 1.3 4.3e-07 29.7 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO53123.1 - 2.4e-15 54.9 8.8 0.0011 18.3 0.5 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO53123.1 - 9.3e-15 54.8 0.3 1.5e-06 28.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO53123.1 - 4.1e-13 48.2 11.2 0.0054 16.2 0.7 4.4 4 0 0 4 4 4 4 EF hand adh_short PF00106.25 KOO53124.1 - 6e-13 48.7 0.0 1.9e-10 40.6 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOO53124.1 - 5.9e-06 26.0 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1501 PF07394.12 KOO53125.1 - 1e-39 136.8 0.0 1.7e-39 136.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) DUF1800 PF08811.11 KOO53125.1 - 2.3e-07 30.2 0.0 3.9e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1800) Pkinase PF00069.25 KOO53126.1 - 5e-06 26.1 0.0 8.3e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain ANAPC8 PF04049.13 KOO53128.1 - 4.6e-28 98.0 0.7 1.8e-27 96.1 0.1 2.1 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_2 PF07719.17 KOO53128.1 - 7.4e-17 60.0 25.4 0.0046 17.0 0.0 8.9 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53128.1 - 5.6e-16 57.3 14.1 0.00037 20.5 0.0 6.9 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53128.1 - 1.3e-15 56.4 20.8 8.8e-05 22.2 0.0 7.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53128.1 - 1.2e-13 50.6 22.5 0.00061 20.4 0.1 8.9 7 3 3 10 10 9 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53128.1 - 6.1e-11 41.8 13.6 1.2e-06 28.1 0.2 4.7 3 1 1 4 4 4 3 TPR repeat TPR_16 PF13432.6 KOO53128.1 - 2e-10 41.2 22.9 0.00049 20.7 1.3 7.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOO53128.1 - 6.3e-10 39.4 21.0 0.027 15.0 1.4 5.9 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO53128.1 - 1.2e-05 25.4 8.3 0.026 14.9 0.2 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53128.1 - 0.00037 20.7 22.8 1.1 9.6 1.5 6.7 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOO53128.1 - 0.0012 19.0 5.1 1.1 9.4 0.5 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO53128.1 - 0.008 16.4 0.1 0.008 16.4 0.1 5.8 3 1 4 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 YfiO PF13525.6 KOO53128.1 - 0.011 15.4 0.4 0.011 15.4 0.4 2.2 3 0 0 3 3 3 0 Outer membrane lipoprotein TPR_7 PF13176.6 KOO53128.1 - 0.016 15.2 19.6 0.049 13.7 0.0 7.6 9 0 0 9 9 9 0 Tetratricopeptide repeat ChAPs PF09295.10 KOO53128.1 - 0.02 13.9 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_6 PF13174.6 KOO53128.1 - 0.054 14.2 23.3 40 5.1 0.1 8.4 7 2 0 7 7 6 0 Tetratricopeptide repeat EF-hand_6 PF13405.6 KOO53133.1 - 2.8e-34 114.1 14.2 4.9e-05 22.9 0.1 11.2 11 0 0 11 11 11 8 EF-hand domain EF-hand_7 PF13499.6 KOO53133.1 - 3.6e-34 117.0 27.7 3.8e-09 36.9 0.1 8.4 8 1 0 8 8 8 6 EF-hand domain pair EF-hand_1 PF00036.32 KOO53133.1 - 3.4e-30 101.3 27.0 1.8e-05 24.0 0.1 10.1 11 0 0 11 11 11 7 EF hand EF-hand_8 PF13833.6 KOO53133.1 - 2.6e-17 62.4 30.9 0.00057 19.7 0.1 9.3 7 2 2 9 9 9 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO53133.1 - 3.2e-13 48.5 20.7 0.0067 15.9 0.2 7.7 7 0 0 7 7 7 5 EF hand SHIPPO-rpt PF07004.12 KOO53133.1 - 5.3e-05 23.9 20.0 0.14 13.1 0.4 6.1 5 1 0 5 5 5 3 Sperm-tail PG-rich repeat EF-hand_4 PF12763.7 KOO53133.1 - 0.00036 20.4 17.7 0.32 11.0 0.1 6.5 5 2 1 6 6 6 3 Cytoskeletal-regulatory complex EF hand Nudix_hydro PF18290.1 KOO53133.1 - 0.018 15.0 0.5 1.7 8.7 0.0 3.5 4 0 0 4 4 4 0 Nudix hydrolase domain Fmp27_GFWDK PF10347.9 KOO53133.1 - 0.055 13.6 1.2 16 5.6 0.0 3.3 3 0 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain DSPc PF00782.20 KOO53134.1 - 5.1e-07 29.6 0.0 8.7e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTEN_C2 PF10409.9 KOO53134.1 - 8.1e-07 28.9 0.0 0.0026 17.5 0.0 2.3 2 0 0 2 2 2 2 C2 domain of PTEN tumour-suppressor protein Ion_trans PF00520.31 KOO53134.1 - 0.00016 21.0 3.9 0.00031 20.0 3.9 1.4 1 0 0 1 1 1 1 Ion transport protein PTPlike_phytase PF14566.6 KOO53134.1 - 0.0025 18.0 0.0 0.0044 17.1 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 KOO53134.1 - 0.0044 16.6 0.0 0.018 14.6 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Glycos_transf_2 PF00535.26 KOO53136.1 - 5.3e-31 107.7 0.0 6.9e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KOO53136.1 - 6.6e-16 58.9 0.0 7.9e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 KOO53136.1 - 3.7e-05 23.3 0.0 5.6e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Anp1 PF03452.14 KOO53136.1 - 0.051 13.0 0.0 2.6 7.4 0.0 2.1 2 0 0 2 2 2 0 Anp1 Glyco_tranf_2_2 PF10111.9 KOO53136.1 - 0.051 13.0 0.0 0.07 12.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Phage_integrase PF00589.22 KOO53137.1 - 0.00027 20.8 0.0 0.00068 19.5 0.0 1.7 1 1 0 1 1 1 1 Phage integrase family HTH_37 PF13744.6 KOO53137.1 - 0.043 13.8 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain ABC_membrane PF00664.23 KOO53137.1 - 0.21 11.2 0.0 0.3 10.7 0.0 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region C2 PF00168.30 KOO53138.1 - 1.1e-13 51.4 0.0 1.9e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 C2 domain P2X_receptor PF00864.19 KOO53138.1 - 0.12 11.4 0.1 0.22 10.5 0.1 1.3 1 0 0 1 1 1 0 ATP P2X receptor DUF4326 PF14216.6 KOO53139.1 - 5.4e-08 33.4 0.7 3.3e-07 30.9 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4326) CART PF06373.11 KOO53139.1 - 0.025 14.8 0.5 0.073 13.3 0.5 1.8 1 0 0 1 1 1 0 Cocaine and amphetamine regulated transcript protein (CART) CENP-Q PF13094.6 KOO53140.1 - 0.013 15.7 1.5 0.014 15.6 1.5 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF3138 PF11336.8 KOO53140.1 - 0.27 9.8 3.4 0.28 9.7 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Metal_resist PF13801.6 KOO53140.1 - 2.8 8.1 17.8 4.9 7.4 17.8 1.3 1 0 0 1 1 1 0 Heavy-metal resistance DUF1425 PF07233.12 KOO53141.1 - 0.00019 21.2 0.1 0.51 10.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1425) DUF4124 PF13511.6 KOO53141.1 - 0.059 13.7 5.8 3.7 8.0 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4124) Arm PF00514.23 KOO53143.1 - 1.6e-62 205.8 34.9 2.9e-09 36.6 0.4 9.6 9 0 0 9 9 9 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO53143.1 - 3.6e-06 27.3 28.9 0.0018 18.7 1.2 6.1 3 2 4 7 7 7 3 HEAT-like repeat Arm_2 PF04826.13 KOO53143.1 - 1.8e-05 24.3 4.0 0.11 11.9 1.2 3.4 1 1 1 2 2 2 2 Armadillo-like CRS1_YhbY PF01985.21 KOO53143.1 - 4.5e-05 23.5 2.0 43 4.4 0.0 6.7 8 0 0 8 8 8 0 CRS1 / YhbY (CRM) domain Atx10homo_assoc PF09759.9 KOO53143.1 - 0.0022 17.9 8.3 2.8 8.0 0.0 4.9 3 1 3 6 6 6 3 Spinocerebellar ataxia type 10 protein domain DUF3192 PF11399.8 KOO53143.1 - 0.16 11.9 0.1 0.43 10.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3192) KAP PF05804.12 KOO53143.1 - 0.19 9.8 0.0 0.79 7.8 0.0 1.9 1 1 0 1 1 1 0 Kinesin-associated protein (KAP) CRAL_TRIO PF00650.20 KOO53145.1 - 0.026 14.2 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 CRAL/TRIO domain Jnk-SapK_ap_N PF09744.9 KOO53146.1 - 0.006 16.8 14.2 0.006 16.8 14.2 3.6 3 2 0 3 3 3 2 JNK_SAPK-associated protein-1 Mod_r PF07200.13 KOO53146.1 - 0.019 15.1 2.7 0.019 15.1 2.7 3.8 3 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Golgin_A5 PF09787.9 KOO53146.1 - 0.03 13.8 0.8 0.03 13.8 0.8 2.9 2 1 1 3 3 3 0 Golgin subfamily A member 5 DUF489 PF04356.12 KOO53146.1 - 0.09 12.8 3.5 0.075 13.0 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF489) Sec8_exocyst PF04048.14 KOO53146.1 - 0.65 9.9 6.3 0.24 11.3 1.9 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain TMF_TATA_bd PF12325.8 KOO53146.1 - 1.3 9.3 26.8 1.3 9.3 0.2 5.2 3 2 2 5 5 5 0 TATA element modulatory factor 1 TATA binding TMPIT PF07851.13 KOO53146.1 - 3 7.0 13.6 0.36 10.0 0.2 2.8 2 1 1 3 3 3 0 TMPIT-like protein Pil1 PF13805.6 KOO53146.1 - 3.2 7.2 18.3 0.022 14.3 6.8 2.9 2 1 1 3 3 3 0 Eisosome component PIL1 COG2 PF06148.11 KOO53146.1 - 8.6 6.4 12.9 2 8.5 0.2 3.8 3 2 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Ribosomal_L9_C PF03948.14 KOO53148.1 - 6.7e-18 64.9 1.6 6.7e-18 64.9 1.6 2.0 2 0 0 2 2 2 1 Ribosomal protein L9, C-terminal domain Ribosomal_L9_N PF01281.19 KOO53148.1 - 1e-09 37.7 0.3 2.5e-09 36.5 0.3 1.7 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain DUF1840 PF08895.11 KOO53148.1 - 3 8.2 6.7 8.8 6.7 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF1840) NodZ PF05830.11 KOO53149.1 - 0.0004 19.3 0.0 0.00064 18.6 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein Z (NodZ) DUF2390 PF09523.10 KOO53149.1 - 0.023 15.0 0.0 0.038 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2390) Tubulin PF00091.25 KOO53150.1 - 2.3e-38 132.4 0.5 4.8e-38 131.3 0.5 1.6 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.8 KOO53150.1 - 4.3e-29 100.7 0.2 1.2e-28 99.2 0.2 1.8 1 0 0 1 1 1 1 FtsZ family, C-terminal domain Tubulin_2 PF13809.6 KOO53150.1 - 0.3 10.2 13.7 0.27 10.4 6.9 2.6 1 1 1 2 2 2 0 Tubulin like Dpy-30 PF05186.13 KOO53151.1 - 4.1e-05 23.2 0.1 8e-05 22.2 0.1 1.5 1 0 0 1 1 1 1 Dpy-30 motif Img2 PF05046.14 KOO53152.1 - 1.8e-08 34.6 0.0 2.7e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SUI1 PF01253.22 KOO53152.1 - 1.9e-07 31.5 0.0 3e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 REV1_C PF16727.5 KOO53152.1 - 0.04 14.3 0.3 0.42 11.0 0.2 2.3 3 0 0 3 3 3 0 DNA repair protein REV1 C-terminal domain FWWh PF14922.6 KOO53154.1 - 0.00016 21.7 0.0 0.00025 21.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function FGE-sulfatase PF03781.16 KOO53155.1 - 4.5e-32 111.7 2.2 4.5e-32 111.7 2.2 1.8 2 0 0 2 2 2 1 Sulfatase-modifying factor enzyme 1 Arm PF00514.23 KOO53156.1 - 3.2e-11 42.8 2.4 0.0012 18.8 0.4 3.6 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOO53156.1 - 0.0002 21.7 7.7 0.04 14.3 0.2 3.8 2 2 3 5 5 5 3 HEAT repeats HEAT PF02985.22 KOO53156.1 - 0.0016 18.6 1.1 1.1 9.7 0.0 3.9 4 0 0 4 4 4 1 HEAT repeat MAS20 PF02064.15 KOO53156.1 - 0.0086 16.2 8.6 0.02 15.0 8.6 1.6 1 0 0 1 1 1 1 MAS20 protein import receptor HEAT_EZ PF13513.6 KOO53156.1 - 0.033 14.7 0.4 5 7.7 0.0 3.8 3 1 1 4 4 4 0 HEAT-like repeat EF-hand_1 PF00036.32 KOO53157.1 - 1.3e-13 49.4 1.2 5e-06 25.7 0.4 2.7 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO53157.1 - 2.8e-10 39.2 0.9 0.00065 19.1 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO53157.1 - 4.6e-10 39.8 0.3 1.2e-09 38.4 0.3 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO53157.1 - 7.3e-09 34.9 0.0 0.0024 17.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KOO53157.1 - 0.00087 19.1 1.0 0.0062 16.4 0.4 2.4 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_4 PF12763.7 KOO53157.1 - 0.0077 16.2 0.0 0.0077 16.2 0.0 1.7 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOO53157.1 - 0.036 14.4 0.2 0.1 12.9 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO53157.1 - 0.061 13.6 0.2 0.25 11.7 0.0 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region IQ PF00612.27 KOO53157.1 - 0.09 12.6 11.0 3.7 7.6 1.2 3.8 3 0 0 3 3 3 0 IQ calmodulin-binding motif EF-hand_1 PF00036.32 KOO53158.1 - 1.6e-23 80.4 11.9 1.6e-08 33.5 0.1 3.1 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOO53158.1 - 2.1e-19 69.7 6.9 2.7e-16 59.8 1.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO53158.1 - 3.6e-17 60.7 6.6 7.3e-08 31.7 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KOO53158.1 - 2.9e-16 59.0 5.9 1.3e-12 47.3 0.2 2.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO53158.1 - 1.1e-15 56.3 5.0 4.7e-07 29.0 0.2 3.2 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 KOO53158.1 - 3e-05 24.2 0.8 0.003 17.8 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO53158.1 - 0.0032 17.8 2.2 1.6 9.1 0.0 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO53158.1 - 0.085 13.1 0.5 0.38 11.0 0.4 2.1 1 1 0 1 1 1 0 Dockerin type I domain Caleosin PF05042.13 KOO53158.1 - 0.15 12.0 0.9 15 5.5 0.0 2.7 1 1 1 3 3 3 0 Caleosin related protein EF-hand_4 PF12763.7 KOO53158.1 - 0.46 10.5 4.1 4.2 7.4 0.7 2.6 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand LRR_6 PF13516.6 KOO53159.1 - 2.5e-19 67.6 6.8 3.1e-07 29.9 0.2 4.4 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.7 KOO53159.1 - 0.0009 19.6 0.4 0.42 11.1 0.0 2.8 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO53159.1 - 0.021 14.6 1.1 0.33 10.8 0.7 2.8 1 1 0 1 1 1 0 Leucine rich repeat T3SS_ExsE PF18286.1 KOO53159.1 - 0.16 11.9 2.6 25 4.9 0.0 3.5 4 0 0 4 4 4 0 Type III secretion system ExsE RabGAP-TBC PF00566.18 KOO53160.1 - 4.6e-16 59.1 0.1 5.8e-16 58.8 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Sec7 PF01369.20 KOO53161.1 - 9.9e-20 71.0 0.0 1.3e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 Sec7 domain CAC1F_C PF16885.5 KOO53161.1 - 0.023 14.4 0.1 0.027 14.2 0.1 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term FAM176 PF14851.6 KOO53161.1 - 0.073 12.7 2.1 0.11 12.2 2.1 1.2 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 KOO53161.1 - 0.92 8.8 2.9 1.3 8.3 2.9 1.2 1 0 0 1 1 1 0 NOA36 protein DUF1800 PF08811.11 KOO53162.1 - 5.3e-25 88.3 0.1 7.8e-25 87.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1800) Gly_transf_sug PF04488.15 KOO53165.1 - 1.3e-12 48.2 0.0 4.4e-12 46.5 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif VPS11_C PF12451.8 KOO53165.1 - 1.9 8.8 3.4 1.8 8.9 0.3 2.3 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal TolA_bind_tri PF16331.5 KOO53165.1 - 5.6 7.1 13.3 0.18 11.9 1.7 3.5 3 1 0 3 3 3 0 TolA binding protein trimerisation HAD_SAK_2 PF18143.1 KOO53166.1 - 4.1e-26 92.0 0.1 5.3e-26 91.6 0.1 1.1 1 0 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins Tim44 PF04280.15 KOO53167.1 - 2.1e-24 86.3 0.7 3e-24 85.8 0.1 1.6 2 0 0 2 2 2 1 Tim44-like domain DUF390 PF04094.14 KOO53167.1 - 0.12 10.6 19.1 0.17 10.1 19.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) SPX PF03105.19 KOO53167.1 - 0.15 11.9 9.6 0.23 11.3 9.6 1.2 1 0 0 1 1 1 0 SPX domain YabA PF06156.13 KOO53167.1 - 0.54 10.9 1.6 1.1 9.9 1.6 1.6 1 0 0 1 1 1 0 Initiation control protein YabA Ndc1_Nup PF09531.10 KOO53167.1 - 3.6 6.2 7.9 4.4 5.9 7.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4776 PF16003.5 KOO53167.1 - 5.3 5.9 7.4 7.3 5.5 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) EF-hand_1 PF00036.32 KOO53168.1 - 0.00021 20.6 0.2 0.0005 19.4 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO53168.1 - 0.0041 16.5 0.1 0.0089 15.5 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOO53168.1 - 0.023 14.5 0.1 0.058 13.3 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_7 PF13499.6 KOO53168.1 - 0.051 14.0 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO53168.1 - 0.06 13.3 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain Nsp1_C PF05064.13 KOO53169.1 - 2.4e-09 37.0 1.0 3.9e-09 36.3 0.3 1.7 2 0 0 2 2 2 1 Nsp1-like C-terminal region Tropomyosin_1 PF12718.7 KOO53169.1 - 0.0098 16.1 2.0 0.018 15.2 0.6 1.9 2 0 0 2 2 2 1 Tropomyosin like HZS_alpha PF18582.1 KOO53169.1 - 0.14 12.6 0.0 0.49 10.9 0.0 2.0 2 1 0 2 2 2 0 Hydrazine synthase alpha subunit middle domain TPR_MLP1_2 PF07926.12 KOO53169.1 - 0.2 11.7 4.9 0.074 13.1 1.9 1.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein CheZ PF04344.13 KOO53169.1 - 0.23 11.4 5.8 0.091 12.7 3.5 1.6 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ DUF724 PF05266.14 KOO53169.1 - 0.29 10.9 3.0 5.4 6.8 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) GST_C_2 PF13410.6 KOO53169.1 - 0.29 11.2 1.1 0.79 9.8 0.1 2.2 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF1664 PF07889.12 KOO53169.1 - 0.3 11.1 3.3 8.4 6.5 0.6 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF1465 PF07323.12 KOO53169.1 - 0.51 10.2 6.0 0.2 11.5 3.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1465) CorA PF01544.18 KOO53169.1 - 0.89 8.8 8.3 2.7 7.2 2.2 2.2 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Ig_mannosidase PF17753.1 KOO53170.1 - 5.8e-14 51.6 0.5 1.5e-13 50.2 0.0 2.0 3 0 0 3 3 3 1 Ig-fold domain Mannosidase_ig PF17786.1 KOO53170.1 - 0.00015 22.3 0.0 0.00032 21.3 0.0 1.6 1 1 0 1 1 1 1 Mannosidase Ig/CBM-like domain Chalcone_3 PF16036.5 KOO53171.1 - 1.2e-10 41.8 0.1 4.7e-10 39.8 0.1 1.7 1 1 0 1 1 1 1 Chalcone isomerase-like Chalcone_2 PF16035.5 KOO53171.1 - 0.0022 17.8 0.1 1.2 8.8 0.0 2.1 1 1 1 2 2 2 2 Chalcone isomerase like EF-hand_1 PF00036.32 KOO53172.1 - 8.3e-13 46.9 0.6 2.9e-05 23.3 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO53172.1 - 8.3e-11 41.6 3.6 3e-05 23.8 0.3 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO53172.1 - 1.4e-09 37.0 0.6 0.00017 20.9 0.0 2.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO53172.1 - 1.5e-09 37.0 0.5 0.003 17.4 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO53172.1 - 1.2e-07 32.0 0.4 1.2e-07 32.0 0.4 2.0 2 0 0 2 2 2 1 EF-hand domain pair DUF2795 PF11387.8 KOO53172.1 - 0.039 14.2 0.1 10 6.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) zf-DNA_Pol PF08996.10 KOO53172.1 - 0.042 13.6 0.1 0.054 13.3 0.1 1.2 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger EF-hand_4 PF12763.7 KOO53172.1 - 0.11 12.5 0.9 3.5 7.6 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Cleaved_Adhesin PF07675.11 KOO53172.1 - 0.2 11.6 1.2 0.88 9.5 0.1 2.0 1 1 1 2 2 2 0 Cleaved Adhesin Domain ECH_2 PF16113.5 KOO53173.1 - 3.9e-27 95.6 0.1 1.4e-26 93.8 0.1 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KOO53173.1 - 1.1e-06 28.1 0.2 1.8e-06 27.5 0.2 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase TPR_2 PF07719.17 KOO53173.1 - 4.7e-05 23.2 0.2 4.7e-05 23.2 0.2 4.1 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53173.1 - 8.5e-05 22.2 0.0 0.00095 18.9 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO53173.1 - 0.00021 21.5 3.0 0.78 10.0 0.1 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KOO53173.1 - 0.00054 20.4 6.9 0.16 12.5 0.1 4.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO53173.1 - 0.0008 19.3 2.7 0.011 15.8 0.2 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53173.1 - 0.004 17.4 0.2 0.004 17.4 0.2 3.9 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOO53173.1 - 0.0054 16.6 0.1 0.0054 16.6 0.1 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOO53173.1 - 0.01 15.1 1.2 0.18 11.0 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53173.1 - 0.027 14.7 0.0 0.16 12.2 0.0 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53173.1 - 0.034 14.9 0.3 0.034 14.9 0.3 5.4 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO53173.1 - 0.16 12.6 0.1 0.16 12.6 0.1 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO53173.1 - 0.32 11.7 0.1 0.32 11.7 0.1 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO53173.1 - 0.62 10.9 0.0 0.62 10.9 0.0 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat Cwf_Cwc_15 PF04889.12 KOO53173.1 - 0.95 9.1 8.6 1.5 8.5 8.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 KOO53173.1 - 3.3 5.7 6.4 4.7 5.2 6.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi AF-4 PF05110.13 KOO53173.1 - 4.3 5.3 14.1 5.8 4.9 14.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Lebercilin PF15619.6 KOO53174.1 - 0.02 14.6 0.7 0.02 14.6 0.7 2.2 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease RNA_pol_Rpb6 PF01192.22 KOO53174.1 - 0.39 10.7 0.0 0.39 10.7 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb6 SlyX PF04102.12 KOO53174.1 - 1.1 9.9 11.9 2 9.1 7.7 2.8 2 0 0 2 2 2 0 SlyX UPF0449 PF15136.6 KOO53174.1 - 4.8 7.7 6.8 40 4.7 0.2 2.5 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Dscam_C PF12355.8 KOO53175.1 - 0.025 15.5 0.8 0.039 14.9 0.8 1.3 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal COesterase PF00135.28 KOO53177.1 - 4.6e-37 128.1 0.0 1.8e-36 126.1 0.0 1.7 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KOO53177.1 - 0.00058 19.8 0.2 0.0021 17.9 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOO53177.1 - 0.05 13.1 0.1 0.12 11.9 0.1 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Sacchrp_dh_NADP PF03435.18 KOO53178.1 - 5.3e-07 29.9 0.0 1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AAA_lid_6 PF17866.1 KOO53179.1 - 2.2e-14 53.4 0.2 2.2e-14 53.4 0.2 1.9 2 0 0 2 2 1 1 AAA lid domain AAA PF00004.29 KOO53179.1 - 1.3e-13 51.5 0.0 2.4e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOO53179.1 - 0.0033 17.7 0.3 1 9.6 0.2 2.5 1 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KOO53179.1 - 0.0053 16.8 0.1 0.017 15.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 KOO53179.1 - 0.0074 16.2 0.3 0.016 15.1 0.3 1.6 1 0 0 1 1 1 1 NTPase Mg_chelatase PF01078.21 KOO53179.1 - 0.0083 15.5 0.5 0.056 12.8 0.3 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI MeaB PF03308.16 KOO53179.1 - 0.0087 15.1 0.6 0.021 13.8 0.6 1.7 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 KOO53179.1 - 0.024 13.9 0.9 1.1 8.4 0.9 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 KOO53179.1 - 0.027 14.5 0.6 0.31 11.1 0.1 2.5 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_28 PF13521.6 KOO53179.1 - 0.034 14.4 1.1 0.16 12.2 0.1 2.3 3 0 0 3 3 2 0 AAA domain AAA_33 PF13671.6 KOO53179.1 - 0.037 14.2 0.1 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KOO53179.1 - 0.04 14.3 0.7 0.15 12.3 0.6 2.0 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOO53179.1 - 0.043 13.5 0.0 0.094 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOO53179.1 - 0.048 14.2 2.1 0.14 12.7 0.3 2.6 3 1 0 3 3 2 0 AAA domain ResIII PF04851.15 KOO53179.1 - 0.059 13.4 0.0 0.16 12.0 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit TrwB_AAD_bind PF10412.9 KOO53179.1 - 0.081 11.8 0.2 0.14 11.0 0.2 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Zot PF05707.12 KOO53179.1 - 0.089 12.4 0.1 3.7 7.1 0.1 2.3 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_16 PF13191.6 KOO53179.1 - 0.096 13.1 0.4 0.28 11.6 0.1 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.6 KOO53179.1 - 1.4 9.4 4.6 5.6 7.4 0.2 2.9 3 0 0 3 3 3 0 AAA domain NAD_binding_1 PF00175.21 KOO53180.1 - 2.4e-14 53.9 0.1 1.1e-11 45.4 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOO53180.1 - 0.0023 18.1 0.0 0.23 11.6 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 KOO53180.1 - 0.075 13.4 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain RVT_2 PF07727.14 KOO53181.1 - 0.045 13.4 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Guanylate_cyc PF00211.20 KOO53182.1 - 8e-46 156.0 0.0 1.1e-45 155.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain WD40 PF00400.32 KOO53183.1 - 2.9e-09 37.4 5.8 2.3e-06 28.2 0.2 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO53183.1 - 1e-06 29.0 0.0 0.17 12.2 0.0 4.0 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain BING4CT PF08149.11 KOO53183.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 BING4CT (NUC141) domain Frtz PF11768.8 KOO53183.1 - 0.24 9.7 0.0 1.4 7.1 0.0 1.8 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 KOO53183.1 - 0.26 10.2 0.1 21 3.9 0.0 2.6 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ion_trans PF00520.31 KOO53184.1 - 1.6e-102 342.0 32.2 1.6e-55 188.1 7.7 2.1 2 0 0 2 2 2 2 Ion transport protein GPHH PF16905.5 KOO53184.1 - 2.4e-06 27.2 0.0 5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KOO53184.1 - 1.4e-05 24.0 35.1 4e-05 22.5 6.9 5.0 4 1 1 5 5 5 3 Polycystin cation channel Spermine_synth PF01564.17 KOO53185.1 - 1.2e-38 132.4 0.0 1.7e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KOO53185.1 - 1.2e-10 41.1 0.1 2.8e-10 39.9 0.1 1.7 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_31 PF13847.6 KOO53185.1 - 1e-07 31.9 0.0 1.8e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO53185.1 - 4.7e-06 27.2 0.0 1.1e-05 26.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO53185.1 - 2.4e-05 24.9 0.0 7.7e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_30 PF05430.11 KOO53185.1 - 0.00014 21.7 0.0 0.00023 21.0 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 KOO53185.1 - 0.0049 16.4 0.0 0.0077 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.6 KOO53185.1 - 0.019 16.0 0.0 0.054 14.5 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOO53185.1 - 0.05 14.4 0.0 0.17 12.6 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_5 PF01795.19 KOO53185.1 - 0.064 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 MraW methylase family TRM PF02005.16 KOO53185.1 - 0.085 12.0 0.0 1.6 7.8 0.0 2.1 2 0 0 2 2 2 0 N2,N2-dimethylguanosine tRNA methyltransferase Cons_hypoth95 PF03602.15 KOO53185.1 - 0.091 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Brix PF04427.18 KOO53187.1 - 2.3e-37 129.0 0.0 3.2e-37 128.5 0.0 1.2 1 0 0 1 1 1 1 Brix domain Methyltransf_31 PF13847.6 KOO53188.1 - 1.6e-30 105.9 0.0 2.4e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO53188.1 - 7.5e-22 77.9 0.6 1.6e-21 76.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO53188.1 - 2.1e-21 76.4 0.5 4.6e-21 75.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOO53188.1 - 3.3e-19 69.2 0.0 4.6e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KOO53188.1 - 3.2e-12 46.6 0.0 4.5e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO53188.1 - 2.4e-10 41.0 0.0 4.2e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOO53188.1 - 1.8e-08 34.1 0.0 2.6e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 KOO53188.1 - 7.5e-07 29.1 0.0 1.7e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.15 KOO53188.1 - 6.7e-06 26.1 1.0 6.4e-05 22.9 1.0 2.1 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 KOO53188.1 - 0.00037 20.1 0.2 0.00085 18.9 0.2 1.7 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 KOO53188.1 - 0.0045 17.0 0.0 0.0061 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOO53188.1 - 0.006 16.1 0.0 0.013 15.0 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase UPF0020 PF01170.18 KOO53188.1 - 0.016 14.9 0.0 0.035 13.8 0.0 1.4 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 GCD14 PF08704.10 KOO53188.1 - 0.02 14.6 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit GidB PF02527.15 KOO53188.1 - 0.024 13.9 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G FtsJ PF01728.19 KOO53188.1 - 0.025 14.7 0.0 0.051 13.7 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Fibrillarin PF01269.17 KOO53188.1 - 0.21 10.7 0.0 0.4 9.7 0.0 1.4 1 0 0 1 1 1 0 Fibrillarin Methyltransf_29 PF03141.16 KOO53188.1 - 0.24 9.9 0.0 0.31 9.5 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase SNF2_N PF00176.23 KOO53191.1 - 6.5e-18 64.6 0.4 1.7e-16 59.9 0.4 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain LRR_6 PF13516.6 KOO53192.1 - 2.9e-08 33.1 34.6 0.00069 19.5 0.2 10.9 13 0 0 13 13 13 3 Leucine Rich repeat LRR_4 PF12799.7 KOO53192.1 - 8.4e-05 22.9 10.0 0.047 14.1 0.2 5.4 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO53192.1 - 0.00018 21.6 1.4 28 5.8 0.0 5.6 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.6 KOO53192.1 - 0.017 14.9 11.1 4.5 7.1 0.2 5.6 5 2 1 6 6 5 0 Leucine rich repeat NMT1_2 PF13379.6 KOO53192.1 - 0.17 11.5 0.5 0.52 9.9 0.1 1.8 2 0 0 2 2 2 0 NMT1-like family FlgT_N PF16548.5 KOO53193.1 - 0.18 12.4 1.6 0.49 11.0 1.6 1.7 1 0 0 1 1 1 0 Flagellar assembly protein T, N-terminal domain LRR_6 PF13516.6 KOO53194.1 - 0.012 15.6 0.1 0.044 13.8 0.1 2.0 1 0 0 1 1 1 0 Leucine Rich repeat SMC_hinge PF06470.13 KOO53195.1 - 4.2e-15 56.1 0.4 3e-14 53.3 0.0 2.7 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain PWWP PF00855.17 KOO53195.1 - 3.8e-12 46.5 0.0 3.8e-12 46.5 0.0 4.4 4 0 0 4 4 4 1 PWWP domain HMG_box PF00505.19 KOO53195.1 - 0.00056 20.3 0.1 0.00056 20.3 0.1 3.3 3 0 0 3 3 3 1 HMG (high mobility group) box Serpin PF00079.20 KOO53196.1 - 4.8e-66 223.6 0.0 5.5e-66 223.4 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNF2_N PF00176.23 KOO53197.1 - 4.5e-38 130.9 0.0 8.7e-38 129.9 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO53197.1 - 2.5e-19 69.6 0.0 6.4e-19 68.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 KOO53197.1 - 1.2e-05 24.6 0.0 2.4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 KOO53197.1 - 0.00017 21.6 0.0 0.011 15.7 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit MBD PF01429.19 KOO53197.1 - 0.00021 20.9 4.9 0.0023 17.6 0.1 3.5 3 0 0 3 3 3 1 Methyl-CpG binding domain CHDCT2 PF08074.11 KOO53197.1 - 0.0032 17.7 0.1 0.0032 17.7 0.1 3.0 3 0 0 3 3 3 1 CHDCT2 (NUC038) domain SLIDE PF09111.10 KOO53197.1 - 0.014 15.4 0.0 0.052 13.6 0.0 2.0 1 0 0 1 1 1 0 SLIDE DEAD PF00270.29 KOO53197.1 - 0.02 14.6 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 KOO53197.1 - 0.054 13.7 2.0 0.091 13.0 0.1 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain FAD_binding_4 PF01565.23 KOO53199.1 - 1.4e-18 66.9 5.9 1.4e-18 66.9 5.9 1.9 2 0 0 2 2 2 1 FAD binding domain adh_short PF00106.25 KOO53199.1 - 0.0024 17.4 1.5 0.0081 15.6 0.2 2.3 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 KOO53199.1 - 0.02 14.8 0.2 0.045 13.7 0.2 1.6 1 0 0 1 1 1 0 KR domain DUF563 PF04577.14 KOO53200.1 - 1.2e-10 41.9 0.1 2.9e-10 40.6 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF563) EamA PF00892.20 KOO53204.1 - 5.7e-28 97.8 27.8 6.1e-15 55.6 9.2 2.2 2 0 0 2 2 2 2 EamA-like transporter family UPF0060 PF02694.15 KOO53204.1 - 1.1 9.5 9.2 0.11 12.8 2.9 2.5 2 1 0 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family EF-hand_1 PF00036.32 KOO53205.1 - 6.2e-13 47.3 0.2 0.00016 21.0 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KOO53205.1 - 9.3e-13 48.4 0.2 1.4e-09 38.2 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOO53205.1 - 1.7e-12 46.2 0.2 0.00061 19.5 0.2 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KOO53205.1 - 3.1e-09 36.5 0.3 5.4e-08 32.6 0.1 2.7 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO53205.1 - 2.1e-07 30.1 0.3 0.086 12.4 0.1 3.4 3 0 0 3 3 3 2 EF hand WW PF00397.26 KOO53205.1 - 1.1e-06 28.6 2.7 2.3e-06 27.6 2.7 1.6 1 0 0 1 1 1 1 WW domain SPARC_Ca_bdg PF10591.9 KOO53205.1 - 0.00011 22.5 0.0 0.029 14.7 0.0 2.4 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOO53205.1 - 0.00088 19.5 0.0 0.49 10.8 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_10 PF14788.6 KOO53205.1 - 0.0038 17.1 0.1 0.011 15.5 0.0 1.9 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 KOO53205.1 - 0.03 14.2 0.2 18 5.4 0.1 3.0 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand DUF5536 PF17688.1 KOO53208.1 - 0.012 15.6 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5536) ATPgrasp_TupA PF14305.6 KOO53209.1 - 4.1e-07 30.0 0.0 4.4e-06 26.7 0.0 2.0 1 1 0 1 1 1 1 TupA-like ATPgrasp ATPgrasp_ST PF14397.6 KOO53209.1 - 0.0032 16.8 0.0 0.0043 16.4 0.0 1.2 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp Actin PF00022.19 KOO53210.1 - 4.9e-10 38.6 0.0 2.2e-08 33.1 0.0 2.2 1 1 1 2 2 2 2 Actin LRR_6 PF13516.6 KOO53212.1 - 1.6e-22 77.6 6.1 6.1e-05 22.8 0.1 6.0 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 KOO53212.1 - 0.0043 17.4 0.0 0.36 11.3 0.0 2.9 3 1 0 3 3 3 1 Leucine Rich repeats (2 copies) FAM25 PF15825.5 KOO53212.1 - 0.0054 17.0 8.9 5 7.5 0.1 4.4 5 0 0 5 5 5 1 FAM25 family LRR_8 PF13855.6 KOO53212.1 - 0.016 15.0 0.0 38 4.2 0.0 3.9 5 0 0 5 5 5 0 Leucine rich repeat LRR_1 PF00560.33 KOO53212.1 - 0.091 13.4 0.0 11 7.0 0.0 3.6 5 0 0 5 5 5 0 Leucine Rich Repeat HHH_2 PF12826.7 KOO53212.1 - 0.097 12.8 1.4 20 5.4 0.2 3.6 3 1 0 3 3 3 0 Helix-hairpin-helix motif HOASN PF14515.6 KOO53212.1 - 0.1 13.0 1.9 3.5 8.1 0.1 3.0 1 1 2 3 3 3 0 Haem-oxygenase-associated N-terminal helices SpoU_sub_bind PF08032.12 KOO53212.1 - 0.25 11.6 0.9 4.4 7.6 0.2 2.8 2 2 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding Arm-DNA-bind_1 PF09003.10 KOO53212.1 - 5.4 7.2 7.8 21 5.4 0.2 3.6 4 0 0 4 4 4 0 Bacteriophage lambda integrase, Arm DNA-binding domain Glyco_hydro_3 PF00933.21 KOO53213.1 - 5e-46 157.5 0.0 8.6e-46 156.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOO53213.1 - 6.1e-19 67.9 0.0 1.8e-18 66.4 0.0 1.9 1 0 0 1 1 1 1 Fibronectin type III-like domain P2X_receptor PF00864.19 KOO53213.1 - 0.0057 15.8 3.7 0.0098 15.0 2.1 2.2 2 1 1 3 3 3 1 ATP P2X receptor CARDB PF07705.11 KOO53213.1 - 0.11 12.8 0.0 0.31 11.3 0.0 1.7 2 0 0 2 2 2 0 CARDB Neuralized PF07177.12 KOO53215.1 - 0.0016 18.5 0.0 2 8.4 0.0 2.3 2 0 0 2 2 2 2 Neuralized CPSase_L_D2 PF02786.17 KOO53216.1 - 1.8e-72 243.3 0.2 2.7e-72 242.7 0.2 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 KOO53216.1 - 1e-67 227.8 0.0 1.9e-67 226.9 0.0 1.5 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_C PF02785.19 KOO53216.1 - 1.2e-31 109.0 0.0 6.7e-31 106.6 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 KOO53216.1 - 2.6e-31 109.2 0.0 5.2e-31 108.2 0.0 1.4 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 KOO53216.1 - 3.4e-16 58.8 3.4 1.4e-12 47.2 0.2 2.6 2 0 0 2 2 2 2 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KOO53216.1 - 4.2e-11 42.5 6.5 0.001 18.9 0.7 3.8 2 1 1 3 3 3 3 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 KOO53216.1 - 8.8e-08 31.9 0.0 2.2e-07 30.6 0.0 1.6 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KOO53216.1 - 1.8e-05 24.4 0.0 7.3e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain HlyD_D23 PF16576.5 KOO53216.1 - 0.00069 18.9 0.4 0.37 10.0 0.1 2.5 1 1 0 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 KOO53216.1 - 0.0011 19.7 1.4 2.2 9.0 0.1 3.4 3 0 0 3 3 3 2 HlyD family secretion protein ATP-grasp_3 PF02655.14 KOO53216.1 - 0.0068 16.5 0.0 0.03 14.4 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 KOO53216.1 - 0.015 14.9 0.0 0.18 11.4 0.0 2.3 1 1 0 1 1 1 0 RimK-like ATP-grasp domain Peptidase_M23 PF01551.22 KOO53216.1 - 0.12 12.6 0.1 32 4.8 0.1 3.1 1 1 2 3 3 3 0 Peptidase family M23 Peptidase_S51 PF03575.17 KOO53218.1 - 3.5e-10 39.9 0.0 4.4e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 TPR_12 PF13424.6 KOO53220.1 - 0.038 14.3 1.4 0.066 13.5 1.4 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat LRR_6 PF13516.6 KOO53221.1 - 6.3e-26 88.2 29.6 0.0021 17.9 1.3 13.4 14 0 0 14 14 14 7 Leucine Rich repeat LRR_4 PF12799.7 KOO53221.1 - 1.3e-09 38.1 2.0 0.14 12.6 0.0 6.0 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO53221.1 - 0.00032 20.8 0.0 38 5.4 0.0 6.8 8 0 0 8 8 8 1 Leucine Rich Repeat DUF5471 PF17565.2 KOO53221.1 - 1.5 9.2 3.4 30 5.0 0.1 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5471) Sigma70_r2 PF04542.14 KOO53223.1 - 1.2e-12 47.3 0.1 3.1e-12 46.1 0.1 1.7 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r3 PF04539.16 KOO53223.1 - 4.7e-10 39.4 6.5 1.2e-07 31.7 0.1 3.8 3 1 0 3 3 3 2 Sigma-70 region 3 Sigma70_r4 PF04545.16 KOO53223.1 - 1.1e-08 34.4 0.5 8.4e-07 28.4 0.2 2.6 2 0 0 2 2 2 1 Sigma-70, region 4 FGAR-AT_linker PF18072.1 KOO53223.1 - 0.0023 18.4 0.5 13 6.4 0.1 3.5 3 0 0 3 3 3 1 Formylglycinamide ribonucleotide amidotransferase linker domain Sigma70_r1_2 PF00140.20 KOO53223.1 - 0.07 13.2 0.4 0.52 10.4 0.2 2.4 2 0 0 2 2 2 0 Sigma-70 factor, region 1.2 SWIRM-assoc_3 PF16498.5 KOO53223.1 - 0.5 10.7 2.8 1.2 9.5 2.8 1.6 1 0 0 1 1 1 0 SWIRM-associated domain at the C-terminal zf-RING_2 PF13639.6 KOO53224.1 - 7.5e-12 45.4 8.4 1.6e-11 44.4 8.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOO53224.1 - 2.4e-10 40.0 6.3 4.4e-10 39.1 6.3 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 KOO53224.1 - 9.4e-07 29.0 5.9 2.3e-06 27.8 5.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOO53224.1 - 1.2e-06 28.3 7.1 2.2e-06 27.5 7.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO53224.1 - 1.6e-06 28.0 8.1 2.9e-06 27.2 8.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOO53224.1 - 3.3e-06 27.0 4.5 7.1e-06 26.0 4.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOO53224.1 - 1.6e-05 24.6 8.2 3.9e-05 23.4 8.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOO53224.1 - 1.9e-05 24.4 6.3 3.7e-05 23.5 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO53224.1 - 4.1e-05 23.4 5.8 7.8e-05 22.5 5.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KOO53224.1 - 0.0005 20.1 2.6 0.00098 19.1 2.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KOO53224.1 - 0.0082 15.7 5.2 0.019 14.6 5.2 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 KOO53224.1 - 0.024 14.7 7.4 0.068 13.3 7.4 1.8 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 KOO53224.1 - 0.32 10.8 10.1 0.79 9.6 10.1 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.5 KOO53224.1 - 0.9 9.6 5.9 7.7 6.6 5.9 2.2 1 1 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 KOO53224.1 - 5.2 7.3 9.4 19 5.5 9.4 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain HORMA PF02301.18 KOO53226.1 - 5.2e-41 140.6 0.0 6.2e-41 140.3 0.0 1.1 1 0 0 1 1 1 1 HORMA domain EF-hand_7 PF13499.6 KOO53227.1 - 3.4e-08 33.8 0.1 1.1e-07 32.2 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOO53227.1 - 2.2e-06 27.4 0.3 5.3e-05 23.0 0.0 2.9 1 1 1 2 2 2 2 EF-hand domain pair NHL PF01436.21 KOO53227.1 - 4.1e-05 23.4 0.5 0.00031 20.6 0.1 2.7 2 0 0 2 2 2 1 NHL repeat EF-hand_6 PF13405.6 KOO53227.1 - 0.0001 21.9 0.0 0.0049 16.7 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KOO53227.1 - 0.00049 19.4 0.9 0.0069 15.9 0.0 3.0 3 0 0 3 3 3 1 EF hand UPF0184 PF03670.13 KOO53227.1 - 0.017 15.5 1.6 0.092 13.1 1.6 2.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) EF-hand_5 PF13202.6 KOO53227.1 - 0.021 14.3 3.2 0.022 14.2 0.0 2.8 3 0 0 3 3 3 0 EF hand DUF5128 PF17170.4 KOO53227.1 - 0.13 11.4 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 6-bladed beta-propeller PT PF04886.12 KOO53228.1 - 1.3 8.6 5.3 3.4 7.3 5.3 1.6 1 0 0 1 1 1 0 PT repeat EF-hand_5 PF13202.6 KOO53230.1 - 3.4e-16 57.9 0.1 3.3e-06 26.3 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO53230.1 - 1.8e-15 55.4 0.0 4e-06 26.3 0.0 3.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOO53230.1 - 2.1e-15 55.0 0.0 9.2e-08 31.1 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO53230.1 - 5e-10 39.7 0.0 9.1e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO53230.1 - 6e-07 29.2 0.0 0.0014 18.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO53230.1 - 0.00017 21.9 0.1 0.15 12.4 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO53230.1 - 0.00019 21.6 0.4 0.011 15.9 0.5 2.3 1 1 1 2 2 2 2 Dockerin type I domain FG-GAP PF01839.23 KOO53230.1 - 0.47 10.6 1.3 11 6.2 0.1 2.4 2 0 0 2 2 2 0 FG-GAP repeat TFIIF_alpha PF05793.12 KOO53231.1 - 0.2 10.2 2.4 0.29 9.7 2.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SR-25 PF10500.9 KOO53231.1 - 9.8 5.7 7.9 18 4.9 7.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SNF2_N PF00176.23 KOO53232.1 - 4.3e-39 134.2 0.0 6.9e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 KOO53232.1 - 0.059 13.4 0.0 6.2 6.8 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 KOO53232.1 - 3.1 7.8 10.4 0.065 13.2 0.8 2.5 2 1 0 2 2 2 0 zinc-RING finger domain LRR_4 PF12799.7 KOO53234.1 - 7e-17 61.3 12.0 0.0002 21.7 1.4 4.8 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO53234.1 - 2.9e-16 59.0 24.8 2.1e-05 24.2 6.5 4.6 3 1 2 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 KOO53234.1 - 9e-06 25.3 8.1 0.057 12.9 0.1 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 KOO53234.1 - 0.024 15.1 12.8 29 5.7 0.2 6.5 6 2 0 6 6 6 0 Leucine Rich Repeat Roc PF08477.13 KOO53234.1 - 0.19 11.9 0.0 0.28 11.4 0.0 1.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PQQ_3 PF13570.6 KOO53236.1 - 1.9e-05 25.0 0.1 0.54 10.8 0.0 3.7 3 0 0 3 3 3 2 PQQ-like domain WD40 PF00400.32 KOO53236.1 - 3.7e-05 24.4 6.0 0.013 16.3 0.5 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat PQQ PF01011.21 KOO53236.1 - 0.11 12.5 0.1 9 6.4 0.0 2.9 2 0 0 2 2 2 0 PQQ enzyme repeat CCB1 PF12046.8 KOO53237.1 - 1.1e-43 148.5 0.0 1.4e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Cofactor assembly of complex C subunit B FeoB_N PF02421.18 KOO53237.1 - 0.18 11.3 0.2 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B adh_short PF00106.25 KOO53238.1 - 1.5e-05 24.6 2.9 4.7e-05 22.9 3.1 1.9 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 KOO53238.1 - 0.00067 19.6 1.2 0.00094 19.1 1.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 KOO53238.1 - 0.0011 18.9 0.2 0.0018 18.2 0.2 1.4 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 KOO53238.1 - 0.0067 15.8 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 KOO53238.1 - 0.0092 15.5 0.1 0.014 14.9 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 KOO53238.1 - 0.026 14.1 0.9 0.048 13.2 0.9 1.4 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Shikimate_DH PF01488.20 KOO53238.1 - 0.031 14.4 0.1 0.055 13.5 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.17 KOO53238.1 - 0.037 13.1 0.1 0.05 12.7 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain F420_oxidored PF03807.17 KOO53238.1 - 0.087 13.4 0.4 0.19 12.3 0.4 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 KOO53238.1 - 0.11 12.1 0.6 0.15 11.6 0.6 1.3 1 0 0 1 1 1 0 NmrA-like family DFP PF04127.15 KOO53238.1 - 0.12 12.1 0.9 0.2 11.5 0.9 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein ThiF PF00899.21 KOO53238.1 - 0.27 10.6 2.8 0.33 10.3 2.0 1.5 1 1 0 1 1 1 0 ThiF family ADH_zinc_N PF00107.26 KOO53238.1 - 0.31 11.0 3.5 6.3 6.8 3.5 2.3 1 1 0 1 1 1 0 Zinc-binding dehydrogenase TPR_1 PF00515.28 KOO53239.1 - 2.5e-15 55.6 25.4 0.016 15.0 0.0 12.1 15 0 0 15 15 15 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO53239.1 - 2.9e-15 55.1 41.5 0.042 14.0 0.0 12.7 14 0 0 14 14 13 6 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53239.1 - 2.2e-14 52.9 13.8 6.8e-05 22.5 0.2 7.9 7 1 1 8 8 8 3 TPR repeat TPR_9 PF13371.6 KOO53239.1 - 2.6e-08 33.9 77.9 0.00077 19.6 4.7 10.4 7 4 3 10 10 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53239.1 - 5.1e-08 32.5 7.5 1.6 9.1 0.0 8.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53239.1 - 3.4e-07 30.4 55.7 0.016 15.5 0.1 10.1 6 4 5 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO53239.1 - 3.9e-06 27.3 11.6 8.8e-05 22.9 0.6 7.0 7 1 0 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO53239.1 - 1.1e-05 25.5 11.8 0.027 14.8 0.1 7.0 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOO53239.1 - 0.0017 19.0 9.3 0.013 16.1 0.6 12.1 9 2 2 11 11 10 5 Tetratricopeptide repeat TPR_6 PF13174.6 KOO53239.1 - 0.01 16.4 0.0 0.01 16.4 0.0 10.1 12 0 0 12 12 12 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53239.1 - 0.067 14.1 0.2 0.067 14.1 0.2 13.3 9 4 4 13 13 12 0 Tetratricopeptide repeat TPR_20 PF14561.6 KOO53239.1 - 0.11 12.8 0.1 0.11 12.8 0.1 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KOO53239.1 - 0.12 12.0 5.8 1.2 8.8 0.1 3.0 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) Surp PF01805.20 KOO53240.1 - 1.4e-38 130.6 0.4 1.9e-19 69.4 0.1 2.4 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 KOO53240.1 - 3.3e-23 82.7 0.6 4.7e-16 59.3 0.0 2.5 1 1 1 2 2 2 2 Pre-mRNA splicing factor PRP21 like protein zf-C2H2_2 PF12756.7 KOO53241.1 - 1.7e-16 60.4 0.0 2.5e-15 56.7 0.0 2.1 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 KOO53241.1 - 0.072 13.4 1.2 0.13 12.6 0.0 2.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding FAM194 PF14977.6 KOO53242.1 - 1.7e-24 86.3 0.0 2.8e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 FAM194 protein Glyco_hydro_3_C PF01915.22 KOO53244.1 - 7.7e-40 137.0 0.1 1.2e-39 136.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 KOO53244.1 - 1.7e-24 85.7 0.0 3.3e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.21 KOO53245.1 - 7.4e-47 160.3 0.0 8.9e-47 160.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain DUF3234 PF11572.8 KOO53245.1 - 0.033 14.4 0.0 0.057 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3234) DENN PF02141.21 KOO53246.1 - 2.5e-22 79.7 0.1 3.9e-22 79.1 0.1 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 KOO53246.1 - 2e-06 28.4 0.1 1.9e-05 25.3 0.0 2.5 2 0 0 2 2 2 1 uDENN domain DUF4407 PF14362.6 KOO53246.1 - 0.55 9.5 6.5 0.77 9.0 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CAP PF00188.26 KOO53247.1 - 2e-07 31.9 0.0 3.5e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family EF-hand_1 PF00036.32 KOO53247.1 - 0.0012 18.2 0.0 0.011 15.2 0.0 2.4 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 KOO53247.1 - 0.0023 17.3 0.0 0.007 15.8 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO53247.1 - 0.0088 15.9 0.0 0.07 13.1 0.0 2.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 KOO53247.1 - 0.03 14.8 0.0 0.12 12.8 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair Filamin PF00630.19 KOO53248.1 - 2.2e-05 25.2 0.0 1.4 9.8 0.0 3.3 2 1 1 3 3 3 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 KOO53248.1 - 0.12 12.7 0.0 2.2 8.6 0.0 2.7 2 1 0 2 2 2 0 Invasin, domain 3 Acyltransferase PF01553.21 KOO53250.1 - 5.2e-10 39.1 0.0 7.1e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase MORN_2 PF07661.13 KOO53250.1 - 0.15 12.4 0.0 0.45 10.9 0.0 1.9 1 0 0 1 1 1 0 MORN repeat variant Filamin PF00630.19 KOO53253.1 - 1.6e-07 32.1 0.0 1.3e-05 25.9 0.0 2.0 2 0 0 2 2 2 2 Filamin/ABP280 repeat DUF824 PF05688.11 KOO53253.1 - 0.011 15.5 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) zf-C3HC4 PF00097.25 KOO53254.1 - 1.9e-05 24.4 5.9 3.8e-05 23.5 5.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOO53254.1 - 1.9e-05 24.6 2.7 1.9e-05 24.6 2.7 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOO53254.1 - 0.00017 21.5 8.6 0.00032 20.6 8.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOO53254.1 - 0.00034 20.4 8.4 0.00068 19.4 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOO53254.1 - 0.0004 20.2 8.0 0.00093 19.0 8.0 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOO53254.1 - 0.001 19.3 9.2 0.0021 18.4 9.2 1.5 1 0 0 1 1 1 1 Ring finger domain Fungal_TACC PF12709.7 KOO53254.1 - 0.0014 19.0 2.0 0.0014 19.0 2.0 3.9 3 1 2 5 5 5 1 Fungal Transforming acidic coiled-coil (TACC) proteins zf-C3HC4_2 PF13923.6 KOO53254.1 - 0.0023 17.7 6.3 0.0075 16.1 6.3 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Exonuc_VII_L PF02601.15 KOO53254.1 - 0.013 15.1 13.9 0.46 10.0 0.9 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Het-C PF07217.11 KOO53254.1 - 0.014 14.0 0.1 0.014 14.0 0.1 2.0 2 0 0 2 2 2 0 Heterokaryon incompatibility protein Het-C zf-C3HC4_4 PF15227.6 KOO53254.1 - 0.051 13.7 9.0 0.13 12.4 9.0 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 KOO53254.1 - 0.079 12.8 6.6 0.18 11.7 6.2 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 KOO53254.1 - 0.24 11.6 7.1 0.47 10.6 7.1 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-UDP PF14569.6 KOO53254.1 - 0.26 11.4 2.3 0.58 10.3 2.3 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger Herpes_IE2_3 PF03361.14 KOO53254.1 - 0.51 10.2 2.2 0.44 10.4 0.3 1.8 2 0 0 2 2 2 0 Herpes virus intermediate/early protein 2/3 Baculo_IE-1 PF05290.11 KOO53254.1 - 0.65 9.9 8.6 0.17 11.8 4.7 2.0 2 1 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) CCDC84 PF14968.6 KOO53254.1 - 0.83 9.2 9.8 0.89 9.1 0.0 3.0 3 0 0 3 3 3 0 Coiled coil protein 84 Rx_N PF18052.1 KOO53254.1 - 2.7 8.3 22.1 2.4 8.5 3.1 4.4 3 2 2 5 5 5 0 Rx N-terminal domain Cnn_1N PF07989.11 KOO53254.1 - 9.3 6.5 16.8 6.5 7.0 3.8 4.1 3 2 0 3 3 3 0 Centrosomin N-terminal motif 1 HATPase_c PF02518.26 KOO53255.1 - 0.00012 22.6 0.0 0.00027 21.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Lipase_GDSL_2 PF13472.6 KOO53256.1 - 0.3 11.5 3.5 10 6.5 0.2 3.2 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family PDZ PF00595.24 KOO53257.1 - 3.3e-07 30.5 0.0 7.8e-06 26.2 0.0 2.4 1 1 1 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KOO53257.1 - 9.7e-06 25.8 0.0 0.00027 21.2 0.0 2.6 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KOO53257.1 - 2e-05 24.3 0.0 0.00013 21.7 0.0 2.2 2 0 0 2 2 2 1 PDZ domain FAIM1 PF06905.13 KOO53257.1 - 2e-05 24.4 0.3 0.00013 21.7 0.1 1.8 1 1 1 2 2 2 1 Fas apoptotic inhibitory molecule (FAIM1) SNF2_N PF00176.23 KOO53258.1 - 1e-35 123.1 0.0 1.4e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO53258.1 - 1.9e-17 63.6 0.0 3.3e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-CXXC PF02008.20 KOO53258.1 - 1.2e-07 31.6 2.7 1.2e-07 31.6 2.7 1.9 2 0 0 2 2 2 1 CXXC zinc finger domain ResIII PF04851.15 KOO53258.1 - 0.012 15.6 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NosD PF05048.13 KOO53259.1 - 0.00024 20.5 0.8 0.00032 20.0 0.8 1.1 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Chlam_PMP PF02415.17 KOO53259.1 - 0.014 15.8 19.3 0.51 10.9 1.1 4.8 4 1 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat TNFR_c6 PF00020.18 KOO53259.1 - 0.35 11.3 9.3 37 4.8 0.1 4.3 4 0 0 4 4 4 0 TNFR/NGFR cysteine-rich region SSB PF00436.25 KOO53259.1 - 0.43 10.6 1.8 7.8 6.6 0.0 2.4 1 1 1 2 2 2 0 Single-strand binding protein family DUF1806 PF08830.10 KOO53259.1 - 0.59 10.0 2.2 5.2 7.0 1.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1806) Pentapeptide_3 PF13576.6 KOO53259.1 - 1.6 9.0 5.5 3.2 8.0 2.5 2.6 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) LRR_6 PF13516.6 KOO53262.1 - 3.8e-16 57.7 1.8 7.9e-05 22.4 0.0 5.4 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.7 KOO53262.1 - 3e-07 30.6 0.8 0.33 11.4 0.0 4.5 3 2 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO53262.1 - 0.0011 18.7 0.7 1.5 8.7 0.5 4.2 4 1 0 4 4 4 1 Leucine rich repeat LRR_1 PF00560.33 KOO53262.1 - 0.0065 16.9 0.2 4.6 8.2 0.0 3.6 3 0 0 3 3 3 1 Leucine Rich Repeat Ank_2 PF12796.7 KOO53262.1 - 0.1 13.2 1.4 4.4 7.9 0.6 2.9 1 1 0 2 2 2 0 Ankyrin repeats (3 copies) Cyclin_N PF00134.23 KOO53263.1 - 3.3e-09 36.6 0.0 3.5e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.11 KOO53263.1 - 4.2e-09 37.0 0.0 7e-09 36.3 0.0 1.4 1 1 0 1 1 1 1 Cyclin VCBS PF13517.6 KOO53264.1 - 1.1e-40 138.1 40.8 3.8e-13 49.8 3.4 4.2 1 1 3 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOO53264.1 - 5.9e-20 71.1 32.9 4.7e-05 23.4 2.3 4.4 4 0 0 4 4 4 4 FG-GAP repeat Dockerin_1 PF00404.18 KOO53264.1 - 0.0016 18.6 8.3 17 5.7 0.0 4.3 4 0 0 4 4 4 2 Dockerin type I domain BBS1 PF14779.6 KOO53264.1 - 0.0079 15.7 0.2 9.8 5.5 0.0 3.7 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 1 TcdB_toxin_midN PF12256.8 KOO53264.1 - 0.0098 15.3 15.0 3.3 7.1 0.2 4.2 2 2 1 4 4 4 4 Insecticide toxin TcdB middle/N-terminal region EF-hand_1 PF00036.32 KOO53264.1 - 0.46 10.1 15.1 20 5.0 0.2 4.2 4 0 0 4 4 4 0 EF hand EF-hand_5 PF13202.6 KOO53264.1 - 0.58 9.8 23.0 8.3 6.1 0.7 4.3 4 0 0 4 4 4 0 EF hand Asp-B-Hydro_N PF05279.11 KOO53264.1 - 0.66 10.0 12.3 37 4.3 0.1 4.1 4 0 0 4 4 4 0 Aspartyl beta-hydroxylase N-terminal region KAR9 PF08580.10 KOO53264.1 - 4.7 5.6 4.4 6.3 5.2 4.4 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 WD40 PF00400.32 KOO53265.1 - 3.3e-71 233.4 15.6 3.2e-09 37.2 0.0 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO53265.1 - 8.1e-19 67.7 1.4 0.0012 19.1 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOO53265.1 - 3.8e-11 42.9 2.0 6.3e-05 22.4 0.2 5.3 2 2 2 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 KOO53265.1 - 2.1e-09 36.8 10.6 0.0064 15.5 1.0 5.8 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KOO53265.1 - 3.6e-09 35.8 9.0 0.085 11.5 0.1 6.3 1 1 6 7 7 7 3 Nucleoporin Nup120/160 eIF2A PF08662.11 KOO53265.1 - 4.6e-07 29.9 2.2 0.073 12.9 0.1 3.4 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.5 KOO53265.1 - 4.9e-05 22.4 3.4 0.59 9.0 0.2 4.2 1 1 1 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 KOO53265.1 - 0.004 15.9 0.1 1.3 7.7 0.0 3.2 2 1 1 3 3 3 1 Nup133 N terminal like CEP19 PF14933.6 KOO53265.1 - 0.0071 16.7 0.0 0.01 16.1 0.0 1.2 1 0 0 1 1 1 1 CEP19-like protein DUF5570 PF17731.1 KOO53265.1 - 0.24 11.5 9.3 7 6.8 0.1 4.4 1 1 4 5 5 5 0 Family of unknown function (DUF5570) Ank_2 PF12796.7 KOO53266.1 - 9.9e-24 83.7 3.5 3.9e-14 53.0 0.9 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOO53266.1 - 6.4e-19 67.5 1.0 5.8e-05 23.4 0.1 4.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 KOO53266.1 - 1.5e-18 66.8 0.4 1.8e-07 31.6 0.1 4.2 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO53266.1 - 5.9e-16 58.3 0.9 2e-06 27.9 0.0 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO53266.1 - 1.4e-13 49.7 0.5 0.0072 16.7 0.1 5.3 6 0 0 6 6 6 4 Ankyrin repeat U1snRNP70_N PF12220.8 KOO53267.1 - 2.6e-19 69.6 2.1 5.2e-19 68.7 2.1 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 KOO53267.1 - 1.8e-17 62.9 0.0 2.8e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TIM21 PF08294.11 KOO53268.1 - 7.4e-12 45.4 0.0 1.1e-11 44.9 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 KOO53268.1 - 0.00043 20.0 0.0 0.001 18.8 0.0 1.6 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 DUF829 PF05705.14 KOO53268.1 - 0.003 17.5 0.0 0.0052 16.7 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) TLD PF07534.16 KOO53270.1 - 4.3e-22 78.8 0.0 6.2e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 TLD Arm PF00514.23 KOO53271.1 - 0.0082 16.2 0.6 3.2 7.9 0.0 3.0 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat EF-hand_1 PF00036.32 KOO53271.1 - 0.15 11.7 0.3 0.29 10.8 0.3 1.5 1 0 0 1 1 1 0 EF hand Atx10homo_assoc PF09759.9 KOO53271.1 - 0.44 10.6 2.8 13 5.9 0.0 3.4 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain WD40 PF00400.32 KOO53272.1 - 4.8e-60 198.1 25.4 1.1e-08 35.5 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO53272.1 - 3.1e-20 72.4 8.5 0.0031 16.5 0.0 6.9 1 1 5 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO53272.1 - 4.2e-18 64.8 0.5 0.61 10.1 0.0 7.4 7 0 0 7 7 7 6 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 KOO53272.1 - 6e-18 64.9 1.5 0.033 14.5 0.1 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOO53272.1 - 3.4e-10 40.1 0.0 0.004 17.1 0.1 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 KOO53272.1 - 8.2e-10 37.6 0.0 0.074 11.4 0.0 4.5 1 1 4 5 5 5 5 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 KOO53272.1 - 9.9e-06 25.1 0.1 0.22 10.8 0.0 3.7 3 1 0 4 4 4 2 WD40-like domain DCX PF03607.17 KOO53272.1 - 5e-05 23.3 0.0 1.1 9.5 0.0 5.3 5 1 1 6 6 6 1 Doublecortin RHS_repeat PF05593.14 KOO53272.1 - 0.0074 16.8 0.0 21 5.7 0.0 3.6 3 0 0 3 3 3 0 RHS Repeat dsrm PF00035.26 KOO53272.1 - 0.042 14.6 0.2 11 6.8 0.0 3.7 5 0 0 5 5 5 0 Double-stranded RNA binding motif Esterase_phd PF10503.9 KOO53272.1 - 0.088 12.3 0.1 3.8 6.9 0.0 2.7 1 1 0 3 3 3 0 Esterase PHB depolymerase Proteasome_A_N PF10584.9 KOO53272.1 - 2.3 8.0 18.7 36 4.1 0.1 6.7 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature BRO1 PF03097.18 KOO53273.1 - 2e-72 244.1 2.1 3.4e-72 243.4 2.1 1.3 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KOO53273.1 - 6.2e-19 68.4 0.4 1.1e-10 41.3 0.0 2.8 2 1 0 2 2 2 2 ALIX V-shaped domain binding to HIV UBA PF00627.31 KOO53273.1 - 1.2e-12 47.4 0.8 2.1e-05 24.3 0.0 3.1 2 0 0 2 2 2 2 UBA/TS-N domain PDZ_6 PF17820.1 KOO53273.1 - 1.2e-10 41.1 0.0 3.2e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO53273.1 - 7.5e-08 32.6 0.0 2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOO53273.1 - 1.3e-07 31.9 0.1 2.8e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 PDZ domain UvrD_C PF13361.6 KOO53273.1 - 0.022 14.1 0.5 0.17 11.3 0.0 2.4 3 0 0 3 3 3 0 UvrD-like helicase C-terminal domain CUE PF02845.16 KOO53273.1 - 0.054 13.2 0.0 4.6 7.1 0.0 3.0 3 0 0 3 3 3 0 CUE domain Tricorn_PDZ PF14685.6 KOO53273.1 - 0.075 13.0 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain DUF5314 PF17241.2 KOO53273.1 - 0.17 11.5 0.1 0.36 10.5 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5314) UBA_4 PF14555.6 KOO53273.1 - 0.19 11.6 1.1 7.4 6.5 0.2 2.7 2 0 0 2 2 2 0 UBA-like domain ACT_7 PF13840.6 KOO53274.1 - 1.5e-20 72.7 0.0 1.7e-09 37.3 0.0 2.3 2 0 0 2 2 2 2 ACT domain Castor1_N PF18700.1 KOO53274.1 - 9.5e-06 25.3 0.0 0.03 14.1 0.0 2.5 2 0 0 2 2 2 2 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain ABATE PF07336.11 KOO53275.1 - 0.046 14.4 0.0 0.053 14.2 0.0 1.1 1 0 0 1 1 1 0 Putative stress-induced transcription regulator DUF501 PF04417.12 KOO53276.1 - 0.54 10.1 3.3 0.47 10.3 1.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF501) TetR_C_31 PF17940.1 KOO53276.1 - 0.65 10.2 9.1 0.069 13.4 0.7 3.1 2 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Aminotran_3 PF00202.21 KOO53277.1 - 2e-115 385.7 0.0 2.4e-115 385.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 KOO53277.1 - 0.0023 17.3 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Baculo_PEP_C PF04513.12 KOO53278.1 - 3.3 7.7 5.5 6.1 6.9 0.5 3.3 2 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.6 KOO53278.1 - 5.1 6.4 40.4 3.7 6.9 9.4 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding LCAT PF02450.15 KOO53279.1 - 5.8e-24 85.0 0.0 1.1e-18 67.7 0.0 2.0 1 1 0 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 KOO53279.1 - 0.00068 20.3 0.0 0.00088 19.9 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOO53279.1 - 0.0018 17.6 0.0 0.0026 17.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF726 PF05277.12 KOO53279.1 - 0.05 12.5 0.0 0.069 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF676 PF05057.14 KOO53279.1 - 0.1 12.1 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 KOO53279.1 - 0.13 11.8 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF915 PF06028.11 KOO53279.1 - 0.18 11.1 0.0 0.35 10.2 0.0 1.4 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Mito_carr PF00153.27 KOO53280.1 - 1.6e-65 217.0 4.8 1.3e-23 82.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein GCP_C_terminal PF04130.13 KOO53281.1 - 1.9e-37 129.4 0.0 2.5e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal JmjC PF02373.22 KOO53282.1 - 2.2e-33 115.1 0.0 4.6e-33 114.1 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 KOO53282.1 - 2.5e-13 49.8 0.1 4.8e-13 48.8 0.1 1.5 1 0 0 1 1 1 1 jmjN domain zf-C3HC PF07967.13 KOO53282.1 - 0.013 15.5 0.1 0.064 13.3 0.0 2.2 3 0 0 3 3 3 0 C3HC zinc finger-like zf-RanBP PF00641.18 KOO53282.1 - 0.14 11.5 2.1 0.34 10.3 2.1 1.7 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Kelch_1 PF01344.25 KOO53283.1 - 4.5e-97 317.5 5.8 1.4e-16 59.8 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KOO53283.1 - 3.4e-61 201.7 0.0 5.5e-12 45.5 0.0 6.1 2 2 4 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KOO53283.1 - 5.3e-56 184.6 0.0 3e-10 39.6 0.0 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KOO53283.1 - 1.7e-43 146.1 0.3 2.2e-06 27.8 0.0 6.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 KOO53283.1 - 1.3e-34 117.9 0.0 1.4e-05 25.0 0.0 6.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 KOO53283.1 - 2.4e-31 107.2 4.6 9.3e-07 28.7 0.0 6.7 7 0 0 7 7 7 5 Kelch motif PQQ_3 PF13570.6 KOO53283.1 - 1.5e-09 38.0 10.7 0.63 10.6 0.1 5.6 6 0 0 6 6 5 3 PQQ-like domain DciA PF05258.12 KOO53283.1 - 4e-09 36.8 0.0 1 9.8 0.0 4.9 5 0 0 5 5 5 3 Dna[CI] antecedent, DciA DUF1668 PF07893.13 KOO53283.1 - 9e-07 28.5 5.7 1.8 7.8 0.0 5.1 1 1 4 5 5 5 4 Protein of unknown function (DUF1668) Glyoxal_oxid_N PF07250.11 KOO53283.1 - 2.6e-06 26.8 0.0 0.18 11.0 0.0 3.4 1 1 3 4 4 4 3 Glyoxal oxidase N-terminus VLPT PF07122.11 KOO53283.1 - 0.0034 17.1 0.1 48 3.8 0.0 4.2 5 0 0 5 5 5 0 Variable length PCR target protein (VLPT) Mannosyl_trans4 PF15971.5 KOO53283.1 - 0.004 17.0 3.8 8 6.3 0.0 4.5 5 0 0 5 5 5 1 DolP-mannose mannosyltransferase Peptidase_S9_N PF02897.15 KOO53283.1 - 0.0046 15.8 0.0 4.9 5.8 0.0 2.7 1 1 2 3 3 3 1 Prolyl oligopeptidase, N-terminal beta-propeller domain RHD_dimer PF16179.5 KOO53283.1 - 0.1 12.6 0.0 25 4.9 0.0 3.3 2 1 2 4 4 4 0 Rel homology dimerisation domain DUF2963 PF11178.8 KOO53283.1 - 0.23 11.2 0.0 69 3.3 0.0 3.5 5 0 0 5 5 5 0 Protein of unknown function (DUF2963) DUF2529 PF10740.9 KOO53283.1 - 0.43 10.2 5.5 51 3.5 0.1 4.4 1 1 2 5 5 5 0 Domain of unknown function (DUF2529) DUF5122 PF17164.4 KOO53283.1 - 0.53 10.6 9.6 17 5.8 0.3 5.1 5 0 0 5 5 5 0 Domain of unknown function (DUF5122) beta-propeller Ig_C17orf99 PF17736.1 KOO53284.1 - 0.006 16.6 5.4 2.9 8.0 0.1 3.2 1 1 2 3 3 3 3 C17orf99 Ig domain OMPdecase PF00215.24 KOO53284.1 - 0.057 13.0 0.0 4.2 6.9 0.0 3.0 1 1 1 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Peptidase_C107 PF17222.3 KOO53285.1 - 0.22 10.5 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 Viral cysteine endopeptidase C107 YchF-GTPase_C PF06071.13 KOO53286.1 - 6.6e-38 128.8 0.2 7.7e-38 128.6 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF933) LRR_6 PF13516.6 KOO53289.1 - 2.9e-16 58.1 52.5 0.52 10.5 0.1 16.9 16 0 0 16 16 16 7 Leucine Rich repeat LRR_1 PF00560.33 KOO53289.1 - 8.2e-14 50.0 14.6 7.6 7.5 0.3 12.2 13 0 0 13 13 13 3 Leucine Rich Repeat LRR_4 PF12799.7 KOO53289.1 - 5.8e-13 48.8 21.5 0.46 11.0 0.0 10.5 11 0 0 11 11 10 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO53289.1 - 6.4e-10 38.6 19.0 12 5.7 0.1 10.9 11 2 0 11 11 11 2 Leucine rich repeat SpoU_sub_bind PF08032.12 KOO53289.1 - 0.001 19.3 4.1 25 5.2 0.1 5.7 5 2 1 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding DUF2202 PF09968.9 KOO53289.1 - 0.014 15.3 4.3 12 5.7 0.0 4.3 5 0 0 5 5 5 0 Uncharacterized protein domain (DUF2202) YusW PF14039.6 KOO53289.1 - 0.028 14.9 0.2 22 5.6 0.0 3.1 3 0 0 3 3 3 0 YusW-like protein DNA_pol_lambd_f PF10391.9 KOO53289.1 - 0.032 14.1 0.0 20 5.1 0.0 4.5 5 0 0 5 5 5 0 Fingers domain of DNA polymerase lambda UPF0181 PF03701.14 KOO53289.1 - 0.044 13.4 10.9 73 3.1 0.0 6.5 7 0 0 7 7 7 0 Uncharacterised protein family (UPF0181) PCP PF02429.15 KOO53289.1 - 0.063 13.6 8.2 67 3.8 0.0 6.1 5 3 2 7 7 7 0 Peridinin-chlorophyll A binding protein TA_inhibitor PF17574.2 KOO53289.1 - 0.088 12.9 9.1 40 4.3 0.1 6.3 7 0 0 7 7 7 0 Inhibitor of toxin/antitoxin system (Gp4.5) zf-CCCH_6 PF18585.1 KOO53289.1 - 1.8 8.5 5.0 7.5 6.5 0.1 4.2 5 0 0 5 5 5 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Arm-DNA-bind_1 PF09003.10 KOO53289.1 - 8.1 6.7 5.1 94 3.3 0.0 4.2 4 1 1 5 5 4 0 Bacteriophage lambda integrase, Arm DNA-binding domain Ras PF00071.22 KOO53290.1 - 3.3e-55 186.1 0.2 3.8e-55 185.9 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOO53290.1 - 7.6e-33 113.3 0.1 2.2e-32 111.8 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOO53290.1 - 1.2e-13 50.9 0.0 1.5e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KOO53290.1 - 2.8e-06 26.9 0.0 4.7e-06 26.2 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 KOO53290.1 - 7.3e-06 26.0 1.5 0.0063 16.4 0.1 2.4 2 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 KOO53290.1 - 5.5e-05 22.6 0.0 7.6e-05 22.2 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO53290.1 - 0.00023 21.2 0.3 0.0035 17.4 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOO53290.1 - 0.0017 17.9 0.1 0.0043 16.6 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 KOO53290.1 - 0.012 15.4 0.1 4.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 KOO53290.1 - 0.017 14.6 0.5 0.2 11.1 0.5 2.4 1 1 0 1 1 1 0 Ferrous iron transport protein B ATPase PF06745.13 KOO53290.1 - 0.078 12.3 0.2 0.12 11.7 0.2 1.5 1 1 0 1 1 1 0 KaiC Pox_A32 PF04665.12 KOO53290.1 - 0.085 12.3 0.1 0.15 11.5 0.1 1.4 1 1 0 1 1 1 0 Poxvirus A32 protein AAA_16 PF13191.6 KOO53290.1 - 0.11 12.9 0.7 0.32 11.4 0.7 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 KOO53290.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOO53290.1 - 0.17 11.6 0.4 0.39 10.4 0.4 1.8 1 1 0 1 1 1 0 AAA domain TTL PF03133.15 KOO53291.1 - 3.9e-73 246.2 0.0 6.7e-73 245.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KOO53291.1 - 2.9e-06 26.7 0.0 7.5e-05 22.1 0.0 2.7 2 1 1 3 3 3 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KOO53291.1 - 0.007 15.6 0.0 0.12 11.6 0.0 2.1 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp DSBA PF01323.20 KOO53291.1 - 8.9 6.0 10.4 20 4.9 1.9 2.6 1 1 1 2 2 2 0 DSBA-like thioredoxin domain W2 PF02020.18 KOO53292.1 - 3.2e-08 33.6 0.0 3.6e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon DSPc PF00782.20 KOO53294.1 - 4.6e-15 55.6 0.0 6.6e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOO53294.1 - 0.027 14.0 0.1 0.044 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KOO53294.1 - 0.15 12.4 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain Mlh1_C PF16413.5 KOO53295.1 - 2.4e-50 171.4 0.0 1.8e-45 155.4 0.0 2.2 1 1 1 2 2 2 2 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 KOO53295.1 - 1.7e-31 108.4 0.0 2.6e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 KOO53295.1 - 8.5e-10 38.6 0.0 1.5e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOO53295.1 - 0.0029 18.1 0.0 0.0055 17.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 KOO53295.1 - 0.0041 16.9 0.1 0.0099 15.6 0.1 1.6 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DUF5129 PF17173.4 KOO53296.1 - 0.0052 16.0 0.8 0.0061 15.7 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5129) Histone_HNS PF00816.21 KOO53296.1 - 0.024 15.5 1.0 0.068 14.0 1.0 1.8 1 1 0 1 1 1 0 H-NS histone family Atg14 PF10186.9 KOO53296.1 - 0.79 8.7 3.5 1 8.3 3.5 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ABC_tran_CTD PF16326.5 KOO53296.1 - 0.95 9.8 6.9 4.5 7.6 6.9 1.9 1 1 0 1 1 1 0 ABC transporter C-terminal domain Ribosomal_L13 PF00572.18 KOO53297.1 - 6e-08 33.0 0.3 4.9e-06 26.8 0.0 2.5 2 1 0 2 2 2 1 Ribosomal protein L13 Ribosomal_L27e PF01777.18 KOO53298.1 - 5.8e-32 109.9 5.3 8.9e-32 109.3 5.3 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 KOO53298.1 - 0.0017 18.3 0.1 0.003 17.5 0.1 1.4 1 0 0 1 1 1 1 KOW motif DUF179 PF02622.15 KOO53299.1 - 1.6e-07 31.4 0.0 3.4e-07 30.4 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 PseudoU_synth_1 PF01416.20 KOO53300.1 - 1.7e-05 25.2 0.0 3.6e-05 24.2 0.0 1.8 1 1 0 1 1 1 1 tRNA pseudouridine synthase RRM_1 PF00076.22 KOO53300.1 - 0.00081 19.2 0.0 0.0018 18.0 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO53300.1 - 0.026 14.4 0.0 0.22 11.4 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif Ribosomal_60s PF00428.19 KOO53301.1 - 0.014 16.0 12.8 0.33 11.6 4.6 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Retrotrans_gag PF03732.17 KOO53301.1 - 0.086 13.1 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Retrotransposon gag protein TetR_C_31 PF17940.1 KOO53302.1 - 4.3 7.6 22.6 13 6.1 1.3 4.9 4 1 1 5 5 5 0 Tetracyclin repressor-like, C-terminal domain WD40 PF00400.32 KOO53303.1 - 2e-11 44.2 0.4 0.00079 20.2 0.0 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO53303.1 - 1.1e-06 28.8 0.0 5.1e-06 26.7 0.0 2.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Kinesin PF00225.23 KOO53303.1 - 0.00013 21.0 0.0 0.00017 20.7 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain RCDG1 PF15725.5 KOO53303.1 - 0.13 12.7 0.2 0.13 12.7 0.2 2.2 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein Ge1_WD40 PF16529.5 KOO53303.1 - 0.16 10.9 0.1 0.39 9.6 0.0 1.6 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HSP70 PF00012.20 KOO53305.1 - 0.23 9.6 0.3 0.24 9.5 0.3 1.0 1 0 0 1 1 1 0 Hsp70 protein OTU PF02338.19 KOO53306.1 - 1.7e-08 35.0 0.0 3.6e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease PABP PF00658.18 KOO53306.1 - 9.2e-08 32.2 0.1 2.1e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain EF-hand_6 PF13405.6 KOO53307.1 - 5.7e-13 47.7 1.9 1.5e-05 24.5 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KOO53307.1 - 2.7e-12 45.3 4.6 4.2e-06 25.9 0.1 2.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KOO53307.1 - 4.2e-12 46.3 0.3 9e-12 45.3 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO53307.1 - 6.7e-09 34.8 5.8 0.00085 18.7 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KOO53307.1 - 0.00011 22.0 8.6 0.0021 17.9 0.4 3.0 2 2 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO53307.1 - 0.089 13.1 0.2 0.19 12.0 0.2 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TPT PF03151.16 KOO53308.1 - 1.7e-21 76.8 11.3 2e-21 76.6 11.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family PHO4 PF01384.20 KOO53310.1 - 1e-09 38.0 1.6 1e-09 38.0 1.6 1.6 2 0 0 2 2 2 1 Phosphate transporter family Rax2 PF12768.7 KOO53311.1 - 1.5 8.3 6.8 2.6 7.4 6.8 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF4567 PF15131.6 KOO53312.1 - 0.035 14.2 0.1 0.09 12.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4567) Methyltransf_24 PF13578.6 KOO53313.1 - 0.0001 23.3 0.0 0.00017 22.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOO53313.1 - 0.031 14.0 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Spc7 PF08317.11 KOO53314.1 - 0.00014 20.9 7.3 0.00021 20.3 7.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein HOOK PF05622.12 KOO53314.1 - 0.0002 19.7 4.1 0.00027 19.2 4.1 1.1 1 0 0 1 1 1 1 HOOK protein ATG16 PF08614.11 KOO53314.1 - 0.00024 21.4 9.2 0.00024 21.4 9.2 2.0 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) UPF0242 PF06785.11 KOO53314.1 - 0.0006 20.0 7.0 0.00091 19.4 7.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Myb_DNA-binding PF00249.31 KOO53314.1 - 0.00094 19.3 0.0 0.0024 18.0 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain TUDOR_5 PF18359.1 KOO53314.1 - 0.0015 18.2 0.0 0.0031 17.2 0.0 1.5 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 ERM PF00769.19 KOO53314.1 - 0.0032 17.3 7.3 0.0054 16.6 7.3 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family TMF_DNA_bd PF12329.8 KOO53314.1 - 0.0038 17.2 5.2 0.0038 17.2 5.2 2.4 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding Myb_DNA-bind_6 PF13921.6 KOO53314.1 - 0.011 16.0 0.0 0.21 11.9 0.0 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain Golgin_A5 PF09787.9 KOO53314.1 - 0.013 15.0 5.9 0.019 14.4 5.9 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 CEP63 PF17045.5 KOO53314.1 - 0.015 15.2 7.1 0.017 15.1 2.4 2.1 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa DUF4795 PF16043.5 KOO53314.1 - 0.019 14.6 6.9 0.031 13.9 6.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Filament PF00038.21 KOO53314.1 - 0.022 14.4 7.1 0.033 13.8 7.1 1.2 1 0 0 1 1 1 0 Intermediate filament protein DUF724 PF05266.14 KOO53314.1 - 0.023 14.5 3.9 0.043 13.6 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) zf-C4H2 PF10146.9 KOO53314.1 - 0.033 14.5 0.0 0.056 13.7 0.0 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DUF4407 PF14362.6 KOO53314.1 - 0.065 12.6 8.1 0.1 11.9 8.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_13 PF13166.6 KOO53314.1 - 0.07 11.8 7.2 0.12 11.0 7.2 1.2 1 0 0 1 1 1 0 AAA domain HAP1_N PF04849.13 KOO53314.1 - 0.084 12.1 6.3 0.13 11.4 6.3 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Tudor_3 PF18115.1 KOO53314.1 - 0.086 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain APG6_N PF17675.1 KOO53314.1 - 0.086 13.4 8.2 0.2 12.2 8.2 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Cep57_CLD PF14073.6 KOO53314.1 - 0.09 12.8 6.6 0.14 12.2 6.6 1.3 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 ZapB PF06005.12 KOO53314.1 - 0.12 12.8 6.9 2.1 8.9 6.9 2.5 1 1 0 1 1 1 0 Cell division protein ZapB Herpes_UL6 PF01763.16 KOO53314.1 - 0.14 10.7 1.2 0.18 10.3 1.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like DHR10 PF18595.1 KOO53314.1 - 0.15 12.2 10.7 0.24 11.4 9.9 1.9 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain Atg14 PF10186.9 KOO53314.1 - 0.17 11.0 4.3 0.26 10.3 4.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.12 KOO53314.1 - 0.19 11.8 12.1 0.43 10.6 12.1 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Lebercilin PF15619.6 KOO53314.1 - 0.2 11.3 10.5 0.1 12.2 5.0 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Minor_capsid_3 PF12691.7 KOO53314.1 - 0.21 11.9 0.9 0.42 11.0 0.9 1.4 1 0 0 1 1 1 0 Minor capsid protein from bacteriophage ADIP PF11559.8 KOO53314.1 - 0.25 11.4 8.5 0.62 10.1 8.4 1.8 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMPIT PF07851.13 KOO53314.1 - 0.28 10.4 2.4 0.39 9.9 2.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein V_ATPase_I PF01496.19 KOO53314.1 - 0.33 8.8 2.0 0.46 8.3 2.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4201 PF13870.6 KOO53314.1 - 0.43 10.3 6.7 0.68 9.6 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) Tropomyosin_1 PF12718.7 KOO53314.1 - 0.44 10.7 11.2 0.62 10.2 10.3 1.7 1 1 0 1 1 1 0 Tropomyosin like Mod_r PF07200.13 KOO53314.1 - 0.48 10.5 5.8 0.67 10.1 5.1 1.5 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Fib_alpha PF08702.10 KOO53314.1 - 0.51 10.5 3.2 0.86 9.8 3.2 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Jnk-SapK_ap_N PF09744.9 KOO53314.1 - 0.97 9.6 9.0 3.1 8.0 9.0 1.8 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 HAUS-augmin3 PF14932.6 KOO53314.1 - 0.97 9.0 7.3 1.6 8.3 7.3 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 YscO-like PF16789.5 KOO53314.1 - 1.1 9.3 10.7 4.3 7.4 0.2 2.3 1 1 1 2 2 2 0 YscO-like protein HAUS6_N PF14661.6 KOO53314.1 - 1.3 8.6 4.7 2.1 7.9 4.7 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF1664 PF07889.12 KOO53314.1 - 2 8.5 4.2 5.8 7.0 4.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) OmpH PF03938.14 KOO53314.1 - 2.4 8.5 12.0 5.2 7.4 12.0 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) BST2 PF16716.5 KOO53314.1 - 4.9 7.8 9.8 12 6.5 6.8 2.3 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF4200 PF13863.6 KOO53314.1 - 7.8 6.9 12.6 5.3 7.5 7.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF4140 PF13600.6 KOO53314.1 - 8.1 7.0 10.0 6.6 7.2 6.2 2.7 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Pkinase PF00069.25 KOO53315.1 - 2e-68 230.7 0.0 2.3e-68 230.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53315.1 - 7.9e-34 117.1 0.0 9.5e-34 116.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO53315.1 - 5.4e-05 22.7 0.0 9.6e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOO53315.1 - 0.00011 21.6 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOO53315.1 - 0.0058 15.5 0.0 0.0087 14.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 KOO53315.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase TmoB PF06234.12 KOO53315.1 - 0.16 12.0 0.0 0.45 10.6 0.0 1.8 2 0 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) Pkinase PF00069.25 KOO53316.1 - 6.8e-66 222.3 0.0 7.9e-66 222.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53316.1 - 1.6e-19 70.2 0.0 2.2e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO53316.1 - 7.3e-09 35.9 0.0 3.9e-06 27.0 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOO53316.1 - 0.0039 16.0 0.1 0.0089 14.8 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 KOO53316.1 - 0.026 14.1 0.6 0.063 12.9 0.6 1.8 1 1 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 KOO53316.1 - 0.036 13.4 0.4 0.066 12.6 0.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOO53316.1 - 0.068 12.8 0.1 0.12 11.9 0.1 1.4 1 1 0 1 1 1 0 RIO1 family Bclt PF15318.6 KOO53316.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative Bcl-2 like protein of testis ABC1 PF03109.16 KOO53316.1 - 0.18 12.0 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 ABC1 family AAA_5 PF07728.14 KOO53317.1 - 1.1e-25 90.2 0.0 4.5e-17 62.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 KOO53317.1 - 7.8e-16 58.2 0.0 8.5e-15 54.9 0.0 2.4 2 0 0 2 2 2 1 Midasin AAA lid domain AAA PF00004.29 KOO53317.1 - 9.7e-12 45.4 0.1 0.00019 21.9 0.0 3.6 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 KOO53317.1 - 1e-11 44.8 0.0 4.3e-10 39.5 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO53317.1 - 4e-09 37.1 0.4 0.002 18.5 0.1 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 KOO53317.1 - 1.4e-07 31.9 0.1 0.005 17.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KOO53317.1 - 1.5e-07 31.4 0.1 0.017 14.9 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein TsaE PF02367.17 KOO53317.1 - 4.9e-07 29.8 0.2 0.021 14.9 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KOO53317.1 - 7.4e-07 29.0 0.0 0.01 15.5 0.0 2.9 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_30 PF13604.6 KOO53317.1 - 1.1e-06 28.5 0.5 0.059 13.1 0.4 2.3 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 KOO53317.1 - 2.4e-06 27.8 0.1 0.029 14.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KOO53317.1 - 2.9e-06 27.8 0.1 0.036 14.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_6 PF12774.7 KOO53317.1 - 3.9e-06 26.1 0.1 0.028 13.4 0.0 2.8 3 0 0 3 3 3 2 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 KOO53317.1 - 4.2e-06 26.4 0.0 0.02 14.4 0.0 2.8 2 0 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 KOO53317.1 - 5.1e-06 26.5 0.8 0.074 13.0 0.1 2.9 3 0 0 3 3 3 2 NACHT domain ABC_tran PF00005.27 KOO53317.1 - 3.5e-05 24.4 0.0 0.0028 18.2 0.0 2.2 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 KOO53317.1 - 5.5e-05 23.1 0.0 0.24 11.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Mg_chelatase PF01078.21 KOO53317.1 - 6.6e-05 22.4 0.1 0.95 8.8 0.1 3.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 KOO53317.1 - 9.6e-05 22.0 1.1 0.15 11.6 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 KOO53317.1 - 0.00012 22.4 0.5 0.1 12.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KOO53317.1 - 0.0002 20.7 0.0 0.68 9.2 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin Roc PF08477.13 KOO53317.1 - 0.00095 19.4 0.0 0.42 10.8 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase T2SSE PF00437.20 KOO53317.1 - 0.0017 17.5 0.1 0.94 8.5 0.0 2.6 2 1 0 2 2 2 1 Type II/IV secretion system protein RuvB_N PF05496.12 KOO53317.1 - 0.002 17.9 0.2 1.2 8.9 0.1 2.8 2 1 1 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain CPT PF07931.12 KOO53317.1 - 0.0028 17.5 1.4 3.1 7.6 0.1 3.3 3 1 0 3 3 2 1 Chloramphenicol phosphotransferase-like protein AAA_24 PF13479.6 KOO53317.1 - 0.0033 17.2 0.0 0.99 9.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 KOO53317.1 - 0.0038 16.4 0.1 0.1 11.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 KOO53317.1 - 0.0054 17.1 0.0 4.2 7.8 0.0 2.3 2 0 0 2 2 2 1 RNA helicase AAA_8 PF12780.7 KOO53317.1 - 0.0055 16.1 0.1 0.19 11.0 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_14 PF13173.6 KOO53317.1 - 0.0058 16.7 0.0 0.05 13.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KOO53317.1 - 0.0059 16.7 0.1 2.7 8.1 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 KOO53317.1 - 0.0081 15.9 0.0 5 6.9 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 KOO53317.1 - 0.017 14.8 0.0 4.5 7.1 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Dynein_heavy PF03028.15 KOO53317.1 - 0.02 15.0 0.0 0.078 13.1 0.0 1.9 2 1 0 2 2 1 0 Dynein heavy chain region D6 P-loop domain Sigma54_activ_2 PF14532.6 KOO53317.1 - 0.029 14.5 0.1 2.1 8.5 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain PhoH PF02562.16 KOO53317.1 - 0.034 13.6 0.0 0.75 9.2 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 KOO53317.1 - 0.04 14.3 0.5 2.5 8.4 0.1 2.6 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 KOO53317.1 - 0.044 13.6 0.1 6 6.7 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase Viral_helicase1 PF01443.18 KOO53317.1 - 0.064 13.0 0.0 4.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 KOO53317.1 - 0.086 13.3 0.0 8.6 6.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 KOO53317.1 - 0.13 11.8 0.3 16 5.0 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP19 PF11022.8 KOO53318.1 - 0.048 14.0 0.1 0.062 13.7 0.1 1.2 1 0 0 1 1 1 0 ATP synthase subunit K EF-hand_7 PF13499.6 KOO53319.1 - 6.2e-25 87.5 1.7 2.5e-13 50.2 0.1 2.9 3 0 0 3 3 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOO53319.1 - 8.7e-23 78.1 6.1 5.3e-05 22.5 0.4 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO53319.1 - 1.3e-20 71.5 7.6 9.2e-06 25.2 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOO53319.1 - 1.1e-19 68.9 7.1 0.00021 20.6 0.4 4.7 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO53319.1 - 5.2e-08 32.6 4.8 0.013 15.3 0.3 4.1 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO53319.1 - 2.3e-05 24.3 0.1 0.0032 17.4 0.0 2.5 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand LRR_6 PF13516.6 KOO53319.1 - 0.0038 17.2 1.2 0.37 10.9 0.0 2.7 2 0 0 2 2 2 1 Leucine Rich repeat LRR_8 PF13855.6 KOO53319.1 - 0.013 15.3 0.0 0.11 12.3 0.1 2.4 1 1 0 1 1 1 0 Leucine rich repeat LRR_4 PF12799.7 KOO53319.1 - 0.05 14.0 0.4 1.2 9.7 0.2 2.6 1 1 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO53319.1 - 0.17 12.5 1.3 10 7.1 1.0 3.3 2 1 0 2 2 2 0 Leucine Rich Repeat Dockerin_1 PF00404.18 KOO53319.1 - 0.2 11.9 2.7 18 5.6 1.0 3.3 3 1 1 4 4 4 0 Dockerin type I domain EF-hand_10 PF14788.6 KOO53319.1 - 0.92 9.4 7.3 38 4.3 0.0 4.0 5 0 0 5 5 5 0 EF hand FG-GAP PF01839.23 KOO53319.1 - 3.6 7.8 6.7 16 5.7 0.2 2.6 2 0 0 2 2 2 0 FG-GAP repeat NAD_binding_10 PF13460.6 KOO53320.1 - 6.9e-18 65.2 0.1 3e-17 63.1 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 KOO53320.1 - 9.1e-16 58.1 0.0 2e-15 57.0 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 KOO53320.1 - 0.00028 20.4 0.0 0.00046 19.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 KOO53320.1 - 0.00031 20.2 0.0 0.39 10.1 0.0 2.5 2 0 0 2 2 2 2 short chain dehydrogenase 3Beta_HSD PF01073.19 KOO53320.1 - 0.0018 17.3 0.0 0.0026 16.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 KOO53320.1 - 0.0022 17.9 0.0 0.12 12.3 0.0 2.4 1 1 0 2 2 2 1 KR domain Sacchrp_dh_NADP PF03435.18 KOO53320.1 - 0.0066 16.7 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 KOO53320.1 - 0.063 13.7 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 KOO53320.1 - 0.14 11.3 0.0 0.56 9.3 0.0 1.9 2 0 0 2 2 2 0 Male sterility protein CF222 PF15661.5 KOO53322.1 - 0.0017 17.3 1.8 0.0017 17.3 1.8 2.4 3 0 0 3 3 3 2 C6orf222, uncharacterised family DUF2075 PF09848.9 KOO53322.1 - 0.0093 15.2 1.6 0.63 9.2 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) DUF3456 PF11938.8 KOO53322.1 - 0.02 15.4 11.6 0.44 11.1 0.3 3.4 2 1 1 3 3 3 0 TLR4 regulator and MIR-interacting MSAP DUF445 PF04286.12 KOO53322.1 - 0.07 12.9 5.9 1 9.1 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF445) SapB_1 PF05184.15 KOO53322.1 - 0.086 12.9 1.4 25 5.0 0.0 3.5 3 0 0 3 3 3 0 Saposin-like type B, region 1 CTU2 PF10288.9 KOO53322.1 - 0.12 12.6 6.4 2.6 8.3 0.5 2.4 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Spore_III_AF PF09581.10 KOO53322.1 - 0.59 10.1 7.7 2.4 8.1 0.6 2.4 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) DUF3584 PF12128.8 KOO53323.1 - 0.0092 13.6 9.8 0.011 13.3 9.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) ATG16 PF08614.11 KOO53323.1 - 0.12 12.6 18.9 0.15 12.3 16.9 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF948 PF06103.11 KOO53323.1 - 0.15 12.4 2.3 1 9.6 0.3 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) IFT57 PF10498.9 KOO53323.1 - 0.16 10.9 5.0 0.36 9.7 2.1 2.0 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Cnn_1N PF07989.11 KOO53323.1 - 0.2 11.9 5.5 2.1 8.6 3.4 3.0 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 CENP-F_leu_zip PF10473.9 KOO53323.1 - 0.37 10.8 11.9 0.53 10.3 9.1 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BLOC1_2 PF10046.9 KOO53323.1 - 0.43 10.9 3.2 1.9 8.9 0.2 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSNAXIP1_N PF15739.5 KOO53323.1 - 0.62 10.5 6.1 0.25 11.7 2.5 2.1 1 1 2 3 3 3 0 Translin-associated factor X-interacting N-terminus Fez1 PF06818.15 KOO53323.1 - 0.71 10.3 14.0 0.27 11.7 10.3 1.9 1 1 1 2 2 2 0 Fez1 KLRAQ PF10205.9 KOO53323.1 - 0.78 10.0 6.0 3.1 8.1 0.3 2.3 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Spc7 PF08317.11 KOO53323.1 - 1.1 8.1 16.8 0.79 8.5 8.9 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein CEP209_CC5 PF16574.5 KOO53323.1 - 2 8.6 9.4 0.84 9.8 1.2 2.3 1 1 1 2 2 2 0 Coiled-coil region of centrosome protein CE290 APG6_N PF17675.1 KOO53323.1 - 3.5 8.2 20.4 43 4.6 20.0 2.3 1 1 0 1 1 1 0 Apg6 coiled-coil region HAUS-augmin3 PF14932.6 KOO53323.1 - 4.2 6.9 15.1 3 7.4 13.6 1.5 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF4200 PF13863.6 KOO53323.1 - 4.2 7.8 11.6 0.63 10.5 5.1 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) Snapin_Pallidin PF14712.6 KOO53323.1 - 7.7 7.0 10.5 14 6.2 0.6 3.1 1 1 1 2 2 2 0 Snapin/Pallidin ADIP PF11559.8 KOO53323.1 - 8.7 6.4 13.8 3.4 7.7 9.6 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding PBP1_TM PF14812.6 KOO53324.1 - 0.023 15.0 9.2 0.056 13.8 9.2 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 KOO53324.1 - 0.25 10.6 4.6 0.38 10.0 4.6 1.2 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 KOO53324.1 - 5.1 5.1 5.6 6.8 4.7 5.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 KOO53324.1 - 5.6 5.1 7.4 7.5 4.7 7.4 1.1 1 0 0 1 1 1 0 CDC45-like protein LRR_4 PF12799.7 KOO53325.1 - 1.1e-14 54.3 6.9 0.00023 21.5 0.0 5.2 5 1 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO53325.1 - 2e-09 37.1 16.7 0.0037 17.0 2.9 5.7 4 2 1 5 5 5 5 Leucine rich repeat LRR_6 PF13516.6 KOO53325.1 - 0.0002 21.1 13.1 2.3 8.5 0.0 5.8 7 0 0 7 7 7 3 Leucine Rich repeat LRR_9 PF14580.6 KOO53325.1 - 0.0047 16.4 1.6 1.4 8.4 0.0 2.7 2 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 KOO53325.1 - 0.056 14.0 9.9 6.3 7.8 0.3 4.9 5 1 0 5 5 5 0 Leucine Rich Repeat EF-hand_6 PF13405.6 KOO53326.1 - 4.9e-34 113.3 9.0 7.3e-05 22.4 0.6 6.5 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.32 KOO53326.1 - 1.3e-32 108.9 9.8 0.00018 20.9 0.2 6.6 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO53326.1 - 2.5e-30 104.7 12.7 1.9e-09 37.8 0.3 4.5 2 2 3 5 5 5 5 EF-hand domain pair EF-hand_8 PF13833.6 KOO53326.1 - 1.2e-20 73.1 8.4 0.0016 18.2 0.1 6.3 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO53326.1 - 8.3e-17 59.9 9.4 0.0066 15.9 0.9 6.5 6 0 0 6 6 6 5 EF hand GPHH PF16905.5 KOO53326.1 - 3.3e-05 23.6 0.0 1.7 8.4 0.0 4.0 3 0 0 3 3 3 2 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_10 PF14788.6 KOO53326.1 - 0.0009 19.1 1.3 3.6 7.5 0.0 4.1 4 1 0 4 4 4 2 EF hand DUF3530 PF12048.8 KOO53326.1 - 0.01 15.3 0.1 0.017 14.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3530) EF-hand_9 PF14658.6 KOO53326.1 - 0.073 13.4 0.2 1.3e+02 3.0 0.0 4.2 4 0 0 4 4 4 0 EF-hand domain Caleosin PF05042.13 KOO53326.1 - 0.27 11.2 0.9 48 3.8 0.0 3.7 2 2 2 4 4 4 0 Caleosin related protein Ion_trans PF00520.31 KOO53327.1 - 5.4e-18 65.1 3.3 8.8e-18 64.4 3.3 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KOO53327.1 - 2.7e-07 30.5 2.3 2.7e-07 30.5 2.3 3.0 4 0 0 4 4 4 1 Ion channel Nup54 PF13874.6 KOO53327.1 - 0.043 13.9 0.7 0.043 13.9 0.7 1.7 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Rootletin PF15035.6 KOO53327.1 - 0.087 12.8 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion CCDC-167 PF15188.6 KOO53327.1 - 1 9.8 2.7 3.2 8.2 0.8 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Chloroa_b-bind PF00504.21 KOO53329.1 - 3.8e-30 105.5 0.2 1.8e-24 87.1 0.0 2.1 1 1 1 2 2 2 2 Chlorophyll A-B binding protein DUF812 PF05667.11 KOO53331.1 - 0.0076 15.2 5.2 0.0091 14.9 5.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF1269 PF06897.12 KOO53331.1 - 0.064 13.5 0.2 0.077 13.3 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) Beta_helix PF13229.6 KOO53333.1 - 8.8e-06 25.6 0.8 1.1e-05 25.3 0.8 1.1 1 0 0 1 1 1 1 Right handed beta helix region Chlam_PMP PF02415.17 KOO53333.1 - 0.18 12.3 7.4 1 9.9 0.5 2.8 3 0 0 3 3 3 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat VacA2 PF03077.14 KOO53333.1 - 2 8.3 11.4 1.4 8.8 4.2 2.3 1 1 1 2 2 2 0 Putative vacuolating cytotoxin Phage_holin_2_4 PF16082.5 KOO53336.1 - 0.049 13.4 0.5 0.1 12.3 0.5 1.5 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Gram_pos_anchor PF00746.21 KOO53336.1 - 0.072 13.0 2.4 0.16 11.9 2.4 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Lycopene_cycl PF05834.12 KOO53336.1 - 0.23 10.5 2.8 0.38 9.7 2.8 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein MFS_1 PF07690.16 KOO53337.1 - 2.1e-18 66.4 27.5 2.9e-18 65.9 27.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Gln-synt_C PF00120.24 KOO53340.1 - 8.1e-19 67.8 0.0 5.3e-17 61.9 0.0 2.1 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 KOO53340.1 - 1.5e-08 34.3 0.0 3.6e-08 33.0 0.0 1.6 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain Calpain_inhib PF00748.19 KOO53343.1 - 0.026 15.1 0.9 0.052 14.1 0.9 1.5 1 0 0 1 1 1 0 Calpain inhibitor RRP36 PF06102.12 KOO53343.1 - 0.11 12.5 7.1 0.19 11.7 7.1 1.3 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 Activator_LAG-3 PF11498.8 KOO53343.1 - 1.2 8.1 5.5 1.8 7.5 5.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Nup54 PF13874.6 KOO53344.1 - 3.7e-08 33.6 5.1 3.7e-08 33.6 5.1 1.8 1 1 1 2 2 2 1 Nucleoporin complex subunit 54 CdhD PF03599.16 KOO53344.1 - 0.042 12.6 0.7 0.073 11.8 0.3 1.5 1 1 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit GldM_C PF12080.8 KOO53344.1 - 0.058 13.6 0.0 0.094 12.9 0.0 1.3 1 0 0 1 1 1 0 GldM C-terminal domain BTB PF00651.31 KOO53344.1 - 3.2 8.0 8.3 2.9 8.1 0.6 3.3 1 1 1 2 2 2 0 BTB/POZ domain TPR_8 PF13181.6 KOO53345.1 - 0.063 13.5 0.0 0.26 11.6 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3958 PF13125.6 KOO53346.1 - 0.025 14.8 4.9 0.048 13.9 4.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3958) FeoB_Cyto PF17910.1 KOO53346.1 - 0.034 14.7 1.7 0.46 11.1 1.5 2.2 2 0 0 2 2 2 0 FeoB cytosolic helical domain DUF1178 PF06676.11 KOO53346.1 - 0.048 14.1 2.7 0.075 13.4 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) TPR_2 PF07719.17 KOO53347.1 - 1.9e-36 121.2 42.4 0.00055 19.8 0.1 15.3 15 0 0 15 15 15 9 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53347.1 - 2.2e-35 119.0 21.3 2.4e-05 23.9 0.0 13.9 15 0 0 15 15 15 8 Tetratricopeptide repeat Cullin_binding PF03556.15 KOO53347.1 - 1.2e-22 80.5 0.0 2.5e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 Cullin binding TPR_11 PF13414.6 KOO53347.1 - 1.6e-14 53.3 15.8 0.0083 15.8 0.0 10.7 9 3 3 12 12 12 4 TPR repeat TPR_16 PF13432.6 KOO53347.1 - 1.2e-11 45.1 73.6 0.0023 18.5 6.5 12.1 9 4 2 12 12 11 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53347.1 - 1.7e-11 43.3 20.8 0.2 12.0 0.0 13.2 13 1 1 14 14 14 1 Tetratricopeptide repeat Phosducin PF02114.16 KOO53347.1 - 5.9e-10 38.5 0.1 2.2e-09 36.6 0.1 1.8 1 1 0 1 1 1 1 Phosducin TPR_19 PF14559.6 KOO53347.1 - 5.3e-09 36.5 40.2 0.0069 16.9 1.5 9.7 5 3 4 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53347.1 - 8.2e-09 35.6 46.6 0.012 15.8 1.4 9.9 9 1 1 10 10 10 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53347.1 - 6e-06 26.6 70.5 0.15 13.0 0.2 14.6 9 3 7 16 16 14 6 Tetratricopeptide repeat TPR_17 PF13431.6 KOO53347.1 - 0.0019 18.4 22.0 0.63 10.5 0.0 9.1 11 1 1 12 12 10 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO53347.1 - 0.0026 17.7 14.9 1.1 9.5 0.0 7.3 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_20 PF14561.6 KOO53347.1 - 0.039 14.3 22.8 0.77 10.1 0.0 6.5 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO53347.1 - 0.057 13.6 44.2 2.3 8.4 3.0 8.8 5 3 3 9 9 9 0 Tetratricopeptide repeat DUF4250 PF14056.6 KOO53347.1 - 0.2 11.7 0.0 0.53 10.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) MIT PF04212.18 KOO53347.1 - 0.99 9.5 4.0 35 4.5 0.1 4.7 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain BTAD PF03704.17 KOO53347.1 - 3.6 8.0 47.9 0.023 15.1 3.0 8.3 6 3 4 10 10 10 0 Bacterial transcriptional activator domain TMEM208_SND2 PF05620.11 KOO53348.1 - 2.3e-36 125.1 3.1 2.6e-36 124.9 3.1 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 zf-A20 PF01754.16 KOO53349.1 - 7.9e-12 44.9 7.1 2e-11 43.6 7.1 1.8 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.16 KOO53349.1 - 1.3e-07 31.6 9.1 1.3e-07 31.6 9.1 1.9 2 0 0 2 2 2 1 AN1-like Zinc finger CAP_N PF01213.19 KOO53349.1 - 5.9 6.3 12.4 9.8 5.6 12.4 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Glyco_transf_25 PF01755.17 KOO53350.1 - 7.9e-05 22.6 0.0 0.0012 18.7 0.0 2.3 2 1 0 3 3 3 1 Glycosyltransferase family 25 (LPS biosynthesis protein) DUF21 PF01595.20 KOO53351.1 - 5e-36 124.0 2.6 7.7e-36 123.4 2.6 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 KOO53351.1 - 8e-08 32.6 0.3 0.0056 17.1 0.0 2.8 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 KOO53351.1 - 0.01 15.9 0.0 0.023 14.7 0.0 1.6 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain Glt_symporter PF03616.14 KOO53351.1 - 0.53 8.9 6.4 0.12 11.1 0.5 2.1 2 0 0 2 2 2 0 Sodium/glutamate symporter IBR PF01485.21 KOO53352.1 - 1.5e-09 37.9 0.9 1.5e-09 37.9 0.9 3.4 2 1 1 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 KOO53352.1 - 0.073 13.1 18.8 0.7 10.0 1.0 2.8 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 KOO53352.1 - 1.1 9.2 27.3 0.56 10.1 11.4 3.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Elf1 PF05129.13 KOO53352.1 - 1.4 9.0 10.3 1.3 9.2 0.1 2.5 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like PIF1 PF05970.14 KOO53353.1 - 1e-19 71.0 0.0 1.2e-19 70.7 0.0 1.0 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 KOO53353.1 - 2e-11 44.0 0.1 2.4e-11 43.7 0.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOO53353.1 - 9.5e-07 29.3 0.1 1.7e-06 28.5 0.1 1.4 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KOO53353.1 - 8e-06 25.4 0.1 1.2e-05 24.8 0.1 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DEAD PF00270.29 KOO53353.1 - 0.011 15.5 0.3 0.71 9.6 0.0 2.2 1 1 1 3 3 3 0 DEAD/DEAH box helicase AAA_7 PF12775.7 KOO53353.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 KOO53353.1 - 0.042 14.2 2.2 0.12 12.7 2.1 1.9 1 1 1 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KOO53353.1 - 0.1 12.9 2.5 2.3 8.5 2.5 2.2 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 KOO53353.1 - 0.11 12.3 0.6 15 5.4 0.1 2.2 2 0 0 2 2 2 0 Helicase AAA_25 PF13481.6 KOO53353.1 - 0.13 11.8 0.0 0.31 10.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KOO53353.1 - 0.14 12.7 0.0 0.74 10.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_5 PF07728.14 KOO53353.1 - 0.16 12.0 0.1 1 9.3 0.1 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 KOO53353.1 - 0.16 11.0 0.2 0.53 9.3 0.1 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Homeodomain PF00046.29 KOO53355.1 - 5.6e-08 32.5 0.5 1.2e-07 31.5 0.1 1.8 2 0 0 2 2 2 1 Homeodomain Myb_DNA-binding PF00249.31 KOO53355.1 - 0.045 14.0 0.1 1.4 9.2 0.1 2.9 2 1 0 2 2 2 0 Myb-like DNA-binding domain Acetyltransf_1 PF00583.25 KOO53356.1 - 3.6e-05 24.0 0.0 6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 KOO53356.1 - 0.016 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Anoctamin PF04547.12 KOO53357.1 - 5.5e-87 292.5 0.0 6.9e-87 292.2 0.0 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel MNNL PF07657.13 KOO53358.1 - 3.8 7.6 6.8 11 6.1 0.3 3.1 1 1 2 3 3 3 0 N terminus of Notch ligand DnaJ PF00226.31 KOO53359.1 - 2.4e-09 37.2 0.1 4.5e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain DUF2752 PF10825.8 KOO53359.1 - 0.07 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) DEAD PF00270.29 KOO53361.1 - 4.7e-07 29.7 0.1 1e-06 28.6 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOO53361.1 - 2.2e-05 24.7 0.2 7.8e-05 23.0 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO53361.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KOO53361.1 - 0.0035 16.5 0.1 0.013 14.6 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein SRP54 PF00448.22 KOO53361.1 - 0.0071 16.0 0.2 0.013 15.1 0.2 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_7 PF12775.7 KOO53361.1 - 0.009 15.5 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ResIII PF04851.15 KOO53361.1 - 0.0093 16.0 0.0 4.3 7.3 0.0 2.2 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 KOO53361.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_14 PF13173.6 KOO53361.1 - 0.015 15.4 0.2 0.12 12.4 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KOO53361.1 - 0.017 15.5 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KOO53361.1 - 0.028 14.0 0.2 0.32 10.5 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 KOO53361.1 - 0.052 13.1 0.1 0.24 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 KOO53361.1 - 0.071 12.3 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 KOO53361.1 - 0.087 13.3 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Sigma54_activ_2 PF14532.6 KOO53361.1 - 0.091 12.9 0.0 0.25 11.5 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 KOO53361.1 - 0.095 13.1 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.26 KOO53361.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 KOO53361.1 - 0.11 12.7 0.0 0.11 12.7 0.0 2.1 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 KOO53361.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 KOO53361.1 - 0.16 11.8 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase Methyltransf_PK PF05891.12 KOO53362.1 - 5.4e-55 186.3 0.0 6.3e-55 186.1 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 KOO53362.1 - 3.6e-15 56.4 0.0 5.7e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO53362.1 - 8.2e-12 45.6 0.1 1.4e-11 44.8 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO53362.1 - 1e-09 39.0 0.0 1.6e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOO53362.1 - 1.1e-07 31.9 0.0 1.5e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 KOO53362.1 - 1.3e-07 31.2 0.0 1.7e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 KOO53362.1 - 4.8e-05 23.2 0.0 6.7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOO53362.1 - 8.7e-05 22.1 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 KOO53362.1 - 0.0085 15.4 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CheR PF01739.18 KOO53362.1 - 0.075 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain adh_short PF00106.25 KOO53362.1 - 0.1 12.0 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DUF4072 PF13284.6 KOO53362.1 - 0.19 12.2 2.4 2.4 8.7 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4072) THOC7 PF05615.13 KOO53364.1 - 0.014 15.7 0.4 0.019 15.2 0.4 1.2 1 0 0 1 1 1 0 Tho complex subunit 7 cNMP_binding PF00027.29 KOO53364.1 - 0.014 15.5 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain Phage_Gp23 PF10669.9 KOO53365.1 - 0.037 14.4 0.0 0.037 14.4 0.0 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Cir_N PF10197.9 KOO53366.1 - 1.2e-09 38.2 4.9 1.2e-09 38.2 4.9 3.9 5 0 0 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR zf-CCHC_6 PF15288.6 KOO53366.1 - 0.0094 15.8 0.1 0.02 14.7 0.1 1.5 1 0 0 1 1 1 1 Zinc knuckle RNase_PH PF01138.21 KOO53367.1 - 1.7e-31 109.4 0.0 2.3e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOO53367.1 - 6.4e-06 26.1 0.0 1.4e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 CE2_N PF17996.1 KOO53368.1 - 0.00057 19.9 0.0 0.055 13.5 0.0 2.8 1 1 2 3 3 3 1 Carbohydrate esterase 2 N-terminal Cadherin_C_2 PF16492.5 KOO53368.1 - 0.0032 18.2 0.2 3.1 8.6 0.0 2.4 2 0 0 2 2 2 2 Cadherin cytoplasmic C-terminal BiPBP_C PF06832.12 KOO53368.1 - 0.016 15.2 0.0 3 8.0 0.0 2.3 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family CBM_2 PF00553.19 KOO53368.1 - 0.41 11.0 6.3 3.4 8.0 0.1 3.1 3 1 1 4 4 4 0 Cellulose binding domain DUF3238 PF11579.8 KOO53369.1 - 0.16 11.8 0.0 0.22 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3238) CAP_N PF01213.19 KOO53369.1 - 0.37 10.2 1.4 0.49 9.8 1.4 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Glyco_hydro_7 PF00840.20 KOO53370.1 - 6.6e-16 58.0 0.3 7e-16 58.0 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 DDE_Tnp_4 PF13359.6 KOO53371.1 - 6.7e-13 48.6 0.0 9.6e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease VARLMGL PF14383.6 KOO53372.1 - 4.8 6.8 7.1 71 3.1 0.2 3.5 3 0 0 3 3 3 0 DUF761-associated sequence motif Glyco_transf_15 PF01793.16 KOO53373.1 - 2.7e-24 86.0 0.0 4.6e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TPR_1 PF00515.28 KOO53373.1 - 1.4e-19 69.0 2.2 0.00025 20.7 0.0 7.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOO53373.1 - 5e-19 66.8 14.6 0.0031 17.5 0.0 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53373.1 - 3.2e-16 59.4 12.3 3e-09 37.0 1.2 5.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53373.1 - 6e-15 54.6 6.2 0.0033 17.1 0.1 6.6 5 2 1 6 6 6 4 TPR repeat TPR_8 PF13181.6 KOO53373.1 - 1.4e-14 53.0 1.2 0.00026 20.9 0.0 5.6 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOO53373.1 - 4.4e-13 48.3 5.0 0.018 15.0 0.0 5.9 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOO53373.1 - 5.3e-11 42.9 13.5 0.0014 19.1 0.4 5.3 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOO53373.1 - 1.9e-08 34.8 39.5 2e-06 28.3 4.5 5.7 2 2 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO53373.1 - 3.3e-08 33.1 17.4 0.0025 17.6 0.2 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53373.1 - 6.5e-08 32.8 22.1 0.27 12.2 0.2 7.7 2 2 5 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOO53373.1 - 0.00012 22.2 3.8 4.8 7.8 0.0 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOO53373.1 - 0.00023 21.2 7.5 0.42 10.8 1.2 4.6 3 2 2 5 5 5 2 Tetratricopeptide repeat MIT PF04212.18 KOO53373.1 - 1.2 9.3 8.5 12 6.1 0.2 3.5 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_21 PF09976.9 KOO53373.1 - 1.7 8.3 6.3 0.24 11.1 1.8 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_5 PF12688.7 KOO53373.1 - 5.7 7.2 8.2 18 5.6 1.3 3.6 2 2 1 3 3 3 0 Tetratrico peptide repeat Laminin_G_3 PF13385.6 KOO53374.1 - 6e-17 62.2 0.1 7.5e-17 61.9 0.1 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4348 PF14254.6 KOO53374.1 - 0.23 10.8 0.0 0.3 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4348) T2SSM_b PF10741.9 KOO53375.1 - 0.0071 16.1 0.9 0.0071 16.1 0.9 3.5 2 2 2 4 4 4 1 Type II secretion system (T2SS), protein M subtype b AAA_13 PF13166.6 KOO53375.1 - 0.035 12.8 17.7 0.54 8.8 11.4 2.1 1 1 1 2 2 2 0 AAA domain Spc7 PF08317.11 KOO53375.1 - 0.27 10.1 22.9 0.082 11.8 3.9 2.3 1 1 0 2 2 2 0 Spc7 kinetochore protein BRE1 PF08647.11 KOO53375.1 - 0.84 9.8 20.8 0.61 10.2 0.4 3.9 3 2 0 3 3 3 0 BRE1 E3 ubiquitin ligase GAS PF13851.6 KOO53375.1 - 3 7.2 22.1 0.023 14.0 2.2 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding ADIP PF11559.8 KOO53375.1 - 5 7.2 30.2 0.39 10.8 3.7 4.4 2 2 2 4 4 4 0 Afadin- and alpha -actinin-Binding Fib_alpha PF08702.10 KOO53375.1 - 5 7.3 6.6 4.9 7.3 0.1 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Filament PF00038.21 KOO53375.1 - 5.4 6.5 25.0 1.6e+03 -1.6 25.0 2.9 1 1 0 1 1 1 0 Intermediate filament protein DUF572 PF04502.13 KOO53375.1 - 8.3 5.9 19.2 3.5 7.2 16.1 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF572) CorA PF01544.18 KOO53375.1 - 8.4 5.6 10.0 1 8.6 1.0 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein MCM_bind PF09739.9 KOO53376.1 - 1.2e-99 334.4 0.0 1.4e-99 334.1 0.0 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor PH PF00169.29 KOO53377.1 - 1.6e-12 47.8 0.0 6e-07 29.9 0.0 2.3 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 KOO53377.1 - 0.003 17.8 0.0 2.2 8.6 0.0 2.2 2 0 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 KOO53377.1 - 0.068 13.6 0.0 8.3 6.9 0.0 2.6 3 1 0 3 3 3 0 Pleckstrin homology domain PH_6 PF15406.6 KOO53377.1 - 0.12 12.7 0.0 1.5 9.2 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain Kinesin PF00225.23 KOO53378.1 - 1.2e-35 123.0 0.0 2e-35 122.3 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO53378.1 - 6.3e-09 35.9 0.0 1.1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding EF-hand_1 PF00036.32 KOO53379.1 - 5.5e-11 41.2 0.0 9.3e-05 21.7 0.1 2.5 2 0 0 2 2 2 2 EF hand F420_oxidored PF03807.17 KOO53379.1 - 2.7e-10 40.7 0.0 5.2e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent EF-hand_7 PF13499.6 KOO53379.1 - 7.9e-10 39.1 0.0 1.3e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOO53379.1 - 2.9e-07 29.9 0.0 0.011 15.5 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KOO53379.1 - 2.3e-06 26.8 0.1 0.0083 15.6 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO53379.1 - 3.5e-06 26.7 0.4 0.0024 17.7 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO53379.1 - 0.01 15.8 0.0 0.86 9.6 0.0 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand 2-Hacid_dh_C PF02826.19 KOO53379.1 - 0.016 14.6 0.0 0.048 13.0 0.0 1.8 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain EF-hand_9 PF14658.6 KOO53379.1 - 0.02 15.2 0.0 0.032 14.6 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain NAD_binding_2 PF03446.15 KOO53379.1 - 0.043 14.0 0.0 0.078 13.1 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 KOO53379.1 - 0.045 13.8 0.0 0.088 12.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 KOO53379.1 - 0.15 11.9 1.6 0.83 9.5 0.1 2.1 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Cluap1 PF10234.9 KOO53380.1 - 0.019 14.4 12.4 0.024 14.0 12.4 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 NPV_P10 PF05531.12 KOO53380.1 - 0.026 15.0 5.5 1.1 9.8 0.5 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein zf-C4H2 PF10146.9 KOO53380.1 - 0.035 14.4 10.1 0.054 13.8 5.5 2.0 1 1 1 2 2 2 0 Zinc finger-containing protein DUF1664 PF07889.12 KOO53380.1 - 0.042 13.9 10.2 0.33 11.0 5.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FmiP_Thoc5 PF09766.9 KOO53380.1 - 0.071 12.4 10.8 0.13 11.5 10.9 1.4 1 1 0 1 1 1 0 Fms-interacting protein/Thoc5 CCDC144C PF14915.6 KOO53380.1 - 0.19 10.8 17.8 0.51 9.4 17.8 1.7 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region GFRP PF06399.13 KOO53380.1 - 0.22 11.5 0.2 0.75 9.7 0.1 1.8 1 1 1 2 2 2 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) GAS PF13851.6 KOO53380.1 - 0.3 10.4 17.9 1 8.6 17.6 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Golgin_A5 PF09787.9 KOO53380.1 - 0.53 9.7 14.4 0.63 9.5 14.4 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DivIVA PF05103.13 KOO53380.1 - 0.54 10.3 20.9 0.21 11.7 11.4 2.5 1 1 1 2 2 2 0 DivIVA protein APG6_N PF17675.1 KOO53380.1 - 0.64 10.5 29.2 2.2 8.8 12.6 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region ArAE_2_N PF10337.9 KOO53380.1 - 0.87 8.5 8.1 1 8.3 8.1 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Fez1 PF06818.15 KOO53380.1 - 0.98 9.8 16.0 1.3 9.4 16.0 1.2 1 0 0 1 1 1 0 Fez1 SesA PF17107.5 KOO53380.1 - 1.2 9.4 13.5 0.15 12.3 3.7 2.1 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases HIP1_clath_bdg PF16515.5 KOO53380.1 - 1.4 9.6 21.0 5.4 7.7 9.6 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 KOO53380.1 - 1.9 7.7 23.3 2.6 7.3 23.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 KOO53380.1 - 2 9.1 10.4 0.97 10.1 2.9 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Peptidase_M61 PF05299.12 KOO53380.1 - 2 8.8 3.9 1.9 8.9 1.2 2.0 1 1 1 2 2 2 0 M61 glycyl aminopeptidase Spc7 PF08317.11 KOO53380.1 - 2.1 7.1 20.5 4.5 6.1 20.4 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein FUSC PF04632.12 KOO53380.1 - 2.4 6.6 18.1 1.8 7.0 16.8 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF2408 PF10303.9 KOO53380.1 - 3.7 8.1 10.1 10 6.7 10.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Exonuc_VII_L PF02601.15 KOO53380.1 - 4.1 6.9 15.5 5.4 6.5 15.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 KOO53380.1 - 5.3 4.8 7.5 5.9 4.7 7.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mod_r PF07200.13 KOO53380.1 - 5.9 7.0 18.4 5.1 7.2 6.6 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein AAA_13 PF13166.6 KOO53380.1 - 7.5 5.0 16.6 17 3.8 16.6 1.5 1 1 0 1 1 1 0 AAA domain Acetyltransf_11 PF13720.6 KOO53380.1 - 7.8 7.0 8.5 0.91 10.0 1.9 2.4 1 1 1 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 FapA PF03961.13 KOO53380.1 - 8.6 4.8 9.6 14 4.2 9.5 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A CREPT PF16566.5 KOO53380.1 - 9 6.5 15.9 10 6.3 6.2 2.0 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour TraG_N PF07916.11 KOO53380.1 - 9.4 5.0 12.3 12 4.7 12.3 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Cys_rich_CPXG PF14255.6 KOO53381.1 - 0.26 11.2 0.9 7.9 6.5 0.1 2.6 3 0 0 3 3 3 0 Cysteine-rich CPXCG NACHT PF05729.12 KOO53383.1 - 1.2e-06 28.6 0.1 2.5e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 NACHT domain SPRY PF00622.28 KOO53383.1 - 0.00024 21.2 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 2 SPRY domain AAA_19 PF13245.6 KOO53383.1 - 0.087 13.2 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF4150 PF13665.6 KOO53383.1 - 0.088 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4150) HAT_KAT11 PF08214.11 KOO53384.1 - 6.1e-23 81.7 0.0 8.6e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Histone acetylation protein PHD PF00628.29 KOO53384.1 - 0.0001 22.1 5.0 0.0001 22.1 5.0 3.0 2 1 1 3 3 3 1 PHD-finger Paired_CXXCH_1 PF09699.10 KOO53384.1 - 0.031 14.0 4.3 9 6.1 0.2 3.8 3 0 0 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C7 PF14522.6 KOO53384.1 - 3.7 7.6 13.5 33 4.6 0.0 3.5 2 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c Serum_albumin PF00273.20 KOO53388.1 - 0.15 11.8 0.1 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 Serum albumin family Pkinase PF00069.25 KOO53390.1 - 6.3e-60 202.8 0.0 8.9e-60 202.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO53390.1 - 7.4e-50 167.0 2.9 1.2e-16 60.6 0.1 3.7 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO53390.1 - 1e-31 110.2 0.0 1.5e-31 109.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO53390.1 - 2.6e-06 27.0 0.0 4.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO53390.1 - 0.00019 21.4 0.0 0.00039 20.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KOO53390.1 - 0.02 14.3 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KOO53390.1 - 0.044 12.8 0.0 0.07 12.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.20 KOO53390.1 - 0.16 11.5 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase AAA PF00004.29 KOO53391.1 - 1.3e-14 54.7 0.0 2.5e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_6 PF17866.1 KOO53391.1 - 6.5e-06 26.2 4.0 0.049 13.8 0.2 2.7 2 0 0 2 2 2 2 AAA lid domain AAA_22 PF13401.6 KOO53391.1 - 7.5e-05 23.0 1.0 0.00068 19.9 0.0 2.9 3 2 0 3 3 2 1 AAA domain AAA_18 PF13238.6 KOO53391.1 - 0.00023 21.7 0.2 0.00079 20.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOO53391.1 - 0.00026 21.2 0.0 0.00054 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOO53391.1 - 0.00077 19.2 1.2 0.002 17.9 0.1 2.1 2 0 0 2 2 2 1 AAA domain DUF853 PF05872.12 KOO53391.1 - 0.0026 16.4 0.2 0.0039 15.9 0.2 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) AAA_5 PF07728.14 KOO53391.1 - 0.0026 17.7 0.2 0.0077 16.2 0.2 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 KOO53391.1 - 0.0044 17.3 0.6 0.028 14.7 0.3 2.6 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.10 KOO53391.1 - 0.0057 16.1 0.0 0.0088 15.5 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 KOO53391.1 - 0.0093 16.4 0.1 0.0093 16.4 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 KOO53391.1 - 0.012 15.4 0.0 0.029 14.1 0.0 1.7 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_17 PF13207.6 KOO53391.1 - 0.026 15.0 0.1 0.064 13.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KOO53391.1 - 0.035 14.0 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 NTPase APS_kinase PF01583.20 KOO53391.1 - 0.046 13.6 0.1 0.096 12.6 0.1 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_2 PF07724.14 KOO53391.1 - 0.068 13.3 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) MobB PF03205.14 KOO53391.1 - 0.074 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 KOO53391.1 - 0.081 12.6 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 KOO53391.1 - 0.088 13.1 0.0 0.27 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 KOO53391.1 - 0.097 12.3 0.1 0.3 10.7 0.0 1.9 2 0 0 2 2 2 0 Thymidylate kinase CbiA PF01656.23 KOO53391.1 - 0.11 12.6 0.1 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 KOO53391.1 - 0.13 12.7 0.0 0.31 11.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 KOO53391.1 - 0.21 12.0 0.0 0.38 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 KOO53391.1 - 0.34 10.3 1.0 1.2 8.6 0.5 2.3 2 1 0 2 2 2 0 PhoH-like protein Ank_2 PF12796.7 KOO53392.1 - 4.6e-17 62.4 0.7 3.5e-08 33.9 0.2 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOO53392.1 - 5.9e-16 58.3 6.3 1.1e-05 25.6 0.4 4.3 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO53392.1 - 1.4e-13 49.7 1.7 0.02 15.4 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 KOO53392.1 - 7.3e-13 48.7 3.0 2.6e-05 24.7 0.1 3.8 1 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOO53392.1 - 1.9e-10 40.7 4.4 0.072 13.6 0.2 4.6 4 0 0 4 4 4 4 Ankyrin repeat Lipoprotein_6 PF01441.19 KOO53393.1 - 0.022 14.8 1.3 0.03 14.3 1.3 1.3 1 0 0 1 1 1 0 Lipoprotein DUF3456 PF11938.8 KOO53393.1 - 0.098 13.2 5.9 0.12 12.8 5.9 1.2 1 0 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP Fib_alpha PF08702.10 KOO53393.1 - 4.1 7.6 18.1 2.8 8.1 15.9 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FliD_N PF02465.18 KOO53393.1 - 8.2 7.2 14.3 0.83 10.4 3.8 2.7 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Cellulase PF00150.18 KOO53394.1 - 3.3e-30 105.5 0.0 4.7e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Exo_endo_phos PF03372.23 KOO53394.1 - 1.5e-10 41.0 0.0 1.4e-08 34.6 0.0 2.8 2 1 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family Mito_carr PF00153.27 KOO53395.1 - 2.9e-14 52.7 6.7 4.4e-08 32.9 0.3 4.2 3 1 1 4 4 4 4 Mitochondrial carrier protein SHIPPO-rpt PF07004.12 KOO53396.1 - 1.6e-09 38.2 19.4 0.0054 17.6 0.0 7.2 7 0 0 7 7 7 4 Sperm-tail PG-rich repeat ART PF01129.18 KOO53397.1 - 3.3e-12 46.2 0.0 4.1e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Ldh_1_C PF02866.18 KOO53398.1 - 1.8e-05 24.7 0.0 1.8e-05 24.7 0.0 2.3 3 1 0 3 3 3 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_C PF02866.18 KOO53399.1 - 9.5e-45 152.5 0.0 2.1e-44 151.4 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KOO53399.1 - 2.3e-40 137.9 0.0 5.3e-40 136.8 0.0 1.6 1 1 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain RPAP3_C PF13877.6 KOO53400.1 - 6.6e-18 65.0 0.0 1.3e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_1 PF00515.28 KOO53400.1 - 4.7e-11 42.0 7.1 0.00047 19.9 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOO53400.1 - 7.6e-06 25.9 2.8 0.054 13.6 0.2 2.6 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 KOO53400.1 - 2.1e-05 24.6 12.4 2.7e-05 24.2 9.6 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO53400.1 - 3.8e-05 23.8 3.7 0.14 12.6 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOO53400.1 - 5.2e-05 23.0 23.2 0.007 16.4 0.6 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53400.1 - 0.00032 20.3 4.9 0.2 11.4 0.3 3.1 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.6 KOO53400.1 - 0.00082 19.8 23.9 0.0024 18.4 0.8 4.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53400.1 - 0.0036 18.0 4.3 0.0036 18.0 4.3 5.9 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOO53400.1 - 0.0092 16.6 7.7 0.0092 16.6 7.7 5.3 3 1 3 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOO53400.1 - 0.33 11.1 2.5 13 6.1 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 KOO53400.1 - 0.79 10.2 4.0 5.8 7.4 4.0 2.3 1 1 0 1 1 1 0 Alkyl sulfatase dimerisation TPR_8 PF13181.6 KOO53400.1 - 4.8 7.6 13.9 3.5 8.1 0.4 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53400.1 - 6.6 7.1 20.7 11 6.3 10.8 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat PspC PF04024.12 KOO53401.1 - 0.017 15.0 0.2 0.043 13.6 0.2 1.7 1 0 0 1 1 1 0 PspC domain Nuc_sug_transp PF04142.15 KOO53402.1 - 2.2e-61 207.7 22.1 2.9e-61 207.3 22.1 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOO53402.1 - 8.4e-11 42.2 28.7 2.5e-05 24.4 7.5 2.6 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOO53402.1 - 5.7e-05 22.5 17.1 0.00013 21.3 17.1 1.5 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.16 KOO53402.1 - 0.0045 16.4 13.1 0.018 14.4 13.1 1.9 1 1 0 1 1 1 1 Triose-phosphate Transporter family Phage_holin_5_2 PF16079.5 KOO53402.1 - 0.086 13.2 8.7 0.13 12.6 0.5 3.0 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V DHR10 PF18595.1 KOO53403.1 - 6.2e-05 23.0 8.5 7.6e-05 22.7 8.5 1.1 1 0 0 1 1 1 1 Designed helical repeat protein 10 domain Zwint PF15556.6 KOO53403.1 - 0.0052 16.3 0.7 0.0054 16.3 0.7 1.1 1 0 0 1 1 1 1 ZW10 interactor Striatin PF08232.12 KOO53403.1 - 0.0074 16.9 2.7 0.009 16.6 2.7 1.1 1 0 0 1 1 1 1 Striatin family Spc7 PF08317.11 KOO53403.1 - 0.011 14.6 3.4 0.012 14.5 3.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein SOGA PF11365.8 KOO53403.1 - 0.017 16.2 1.0 0.019 16.1 1.0 1.2 1 0 0 1 1 1 0 Protein SOGA Filament PF00038.21 KOO53403.1 - 0.019 14.6 2.4 0.019 14.6 2.4 1.1 1 0 0 1 1 1 0 Intermediate filament protein ATG16 PF08614.11 KOO53403.1 - 0.03 14.6 8.1 0.027 14.7 7.5 1.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) GAS PF13851.6 KOO53403.1 - 0.053 12.9 1.4 0.06 12.7 1.4 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding SlyX PF04102.12 KOO53403.1 - 0.066 13.8 6.3 0.083 13.5 6.3 1.4 1 1 0 1 1 1 0 SlyX COG2 PF06148.11 KOO53403.1 - 0.086 12.9 2.5 0.096 12.8 2.5 1.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3450 PF11932.8 KOO53403.1 - 0.12 11.7 3.8 0.13 11.5 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Bap31_Bap29_C PF18035.1 KOO53403.1 - 0.12 12.4 1.4 0.68 10.0 1.4 2.2 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain APG6_N PF17675.1 KOO53403.1 - 0.18 12.3 6.3 0.21 12.1 6.3 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region HalX PF08663.10 KOO53403.1 - 0.33 11.3 11.4 1.3 9.4 11.4 2.0 1 1 0 1 1 1 0 HalX domain Glyco_hydro_65C PF03633.15 KOO53404.1 - 0.098 12.6 0.3 0.29 11.1 0.3 1.8 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain NYN PF01936.18 KOO53406.1 - 9e-19 68.4 0.0 1.5e-18 67.7 0.0 1.3 1 0 0 1 1 1 1 NYN domain UQ_con PF00179.26 KOO53407.1 - 5.2e-52 175.2 0.0 7.3e-30 103.4 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOO53407.1 - 7e-07 29.0 0.0 0.016 14.9 0.0 2.5 2 0 0 2 2 2 2 Prokaryotic E2 family B RWD PF05773.22 KOO53407.1 - 3.8e-06 27.2 0.0 0.02 15.2 0.0 2.4 2 0 0 2 2 2 2 RWD domain UEV PF05743.13 KOO53407.1 - 2.2e-05 24.3 0.1 0.0016 18.3 0.0 2.5 2 0 0 2 2 2 1 UEV domain Pkinase PF00069.25 KOO53408.1 - 3.1e-48 164.4 0.0 4.8e-48 163.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 KOO53408.1 - 5.1e-25 87.4 3.7 9.9e-12 44.8 0.1 3.3 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KOO53408.1 - 1.4e-20 73.7 0.0 2.9e-20 72.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase RGS PF00615.19 KOO53408.1 - 2.3e-05 24.6 0.0 0.00028 21.2 0.0 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Kinase-like PF14531.6 KOO53408.1 - 0.0091 15.3 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DUF4888 PF16229.5 KOO53408.1 - 0.013 15.5 0.1 0.025 14.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4888) APH PF01636.23 KOO53408.1 - 0.11 12.4 0.0 0.11 12.4 0.0 3.0 3 0 0 3 3 3 0 Phosphotransferase enzyme family RVT_2 PF07727.14 KOO53409.1 - 0.0059 16.3 0.0 0.0071 16.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 KOO53410.1 - 0.071 12.5 0.1 0.083 12.2 0.1 1.0 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53410.1 - 0.12 11.6 0.1 0.14 11.4 0.1 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase Exostosin PF03016.15 KOO53411.1 - 1.1e-43 149.6 0.0 1.9e-43 148.8 0.0 1.3 1 0 0 1 1 1 1 Exostosin family Spc7 PF08317.11 KOO53411.1 - 0.0035 16.3 19.9 0.0035 16.3 19.9 4.0 1 1 3 4 4 4 2 Spc7 kinetochore protein PKcGMP_CC PF16808.5 KOO53411.1 - 7 6.6 9.7 7.8 6.5 4.2 3.8 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF1664 PF07889.12 KOO53411.1 - 7.7 6.6 21.3 1.9 8.5 0.3 4.3 2 2 3 5 5 5 0 Protein of unknown function (DUF1664) Beta_elim_lyase PF01212.21 KOO53412.1 - 1.3e-29 103.4 0.0 1.8e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase LRR_8 PF13855.6 KOO53414.1 - 3.7e-14 52.2 10.6 4.4e-05 23.2 1.5 4.1 5 0 0 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 KOO53414.1 - 2e-10 40.8 12.5 8.2e-05 22.9 0.4 4.7 4 1 0 5 5 5 2 Leucine Rich repeats (2 copies) Zeta_toxin PF06414.12 KOO53414.1 - 9.6e-09 34.8 0.0 0.002 17.4 0.0 2.8 2 1 0 2 2 2 2 Zeta toxin LRR_1 PF00560.33 KOO53414.1 - 2.5e-06 27.2 8.9 7.1 7.6 0.1 6.4 6 0 0 6 6 6 2 Leucine Rich Repeat DUF4201 PF13870.6 KOO53414.1 - 0.00099 18.9 6.2 0.00099 18.9 6.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) AAA_33 PF13671.6 KOO53414.1 - 0.0013 18.9 0.0 0.0059 16.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain YABBY PF04690.13 KOO53414.1 - 0.069 13.7 4.1 0.6 10.7 4.1 2.3 1 1 0 1 1 1 0 YABBY protein AAA PF00004.29 KOO53414.1 - 0.13 12.7 0.0 0.89 10.0 0.0 2.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 KOO53414.1 - 1.2 9.5 5.3 2 8.9 0.0 3.8 3 1 1 4 4 4 0 AAA domain Leucyl-specific PF14795.6 KOO53414.1 - 1.3 9.1 4.4 2.1 8.5 0.1 3.0 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain Syntaxin_2 PF14523.6 KOO53414.1 - 1.4 9.3 4.7 0.38 11.1 0.8 2.1 2 0 0 2 2 2 0 Syntaxin-like protein Snapin_Pallidin PF14712.6 KOO53414.1 - 1.4 9.3 11.9 0.029 14.8 2.5 3.1 4 0 0 4 4 3 0 Snapin/Pallidin LRR_6 PF13516.6 KOO53414.1 - 6 7.2 9.6 9.7 6.5 0.1 4.7 5 0 0 5 5 5 0 Leucine Rich repeat SET PF00856.28 KOO53415.1 - 1.3e-08 35.4 0.0 5.4e-08 33.4 0.0 2.0 2 1 0 2 2 2 1 SET domain SAF PF08666.12 KOO53415.1 - 0.13 12.9 0.1 3.8 8.2 0.1 2.6 2 0 0 2 2 2 0 SAF domain AP2 PF00847.20 KOO53416.1 - 0.11 12.7 6.9 4.5 7.6 0.1 3.5 3 0 0 3 3 3 0 AP2 domain DUF4145 PF13643.6 KOO53417.1 - 0.0053 16.9 0.0 0.01 16.0 0.0 1.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4145) MerR-DNA-bind PF09278.11 KOO53417.1 - 0.32 11.6 2.0 2.7 8.6 1.0 2.6 1 1 1 2 2 2 0 MerR, DNA binding zf-CXXC PF02008.20 KOO53418.1 - 1.5e-06 28.1 2.8 2.8e-06 27.2 2.8 1.4 1 0 0 1 1 1 1 CXXC zinc finger domain Methyltransf_21 PF05050.12 KOO53419.1 - 1.1e-05 25.6 0.0 2.6e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase FkbM domain NPCBM_assoc PF10633.9 KOO53419.1 - 0.0028 17.9 0.4 0.013 15.7 0.1 2.1 2 0 0 2 2 2 1 NPCBM-associated, NEW3 domain of alpha-galactosidase SDA1 PF05285.12 KOO53420.1 - 6.9e-45 154.0 32.4 2e-27 96.5 0.3 2.9 2 1 1 3 3 3 2 SDA1 NUC130_3NT PF08158.12 KOO53420.1 - 6.5e-21 74.4 0.2 1.2e-19 70.3 0.1 2.8 2 0 0 2 2 2 1 NUC130/3NT domain ERAP1_C PF11838.8 KOO53420.1 - 0.051 13.1 2.8 0.61 9.6 1.0 2.7 3 0 0 3 3 3 0 ERAP1-like C-terminal domain AAA_5 PF07728.14 KOO53421.1 - 3e-21 75.8 0.0 5.7e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 KOO53421.1 - 2.2e-13 50.4 0.1 9.9e-13 48.2 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain ABC_tran PF00005.27 KOO53421.1 - 0.0041 17.6 0.0 0.0084 16.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter RNA_helicase PF00910.22 KOO53421.1 - 0.0067 16.8 0.0 0.019 15.3 0.0 1.8 1 0 0 1 1 1 1 RNA helicase TsaE PF02367.17 KOO53421.1 - 0.019 15.0 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 KOO53421.1 - 0.024 14.6 0.0 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_23 PF13476.6 KOO53421.1 - 0.033 14.7 0.1 0.1 13.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 KOO53421.1 - 0.052 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 KOO53421.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 KOO53421.1 - 0.13 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_18 PF13238.6 KOO53421.1 - 0.19 12.3 0.0 0.8 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 KOO53422.1 - 8.7e-105 350.3 0.0 1.4e-104 349.6 0.0 1.4 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO53422.1 - 6.4e-103 344.9 0.0 6.4e-103 344.9 0.0 2.9 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 KOO53422.1 - 5.5e-31 107.8 0.0 1.6e-30 106.3 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Apolipoprotein PF01442.18 KOO53422.1 - 5.1e-05 23.2 28.8 0.0011 18.8 3.2 6.3 6 1 0 6 6 6 2 Apolipoprotein A1/A4/E domain AAA_24 PF13479.6 KOO53422.1 - 0.0028 17.4 0.0 0.0096 15.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KOO53422.1 - 0.0099 16.3 0.0 0.035 14.5 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FlgN PF05130.12 KOO53422.1 - 0.021 15.3 0.8 0.021 15.3 0.8 5.5 5 0 0 5 5 5 0 FlgN protein JIP_LZII PF16471.5 KOO53422.1 - 0.061 13.5 0.0 2.3 8.5 0.7 3.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II AAA_16 PF13191.6 KOO53422.1 - 0.12 12.8 2.1 2.1 8.7 0.0 3.8 3 0 0 3 3 3 0 AAA ATPase domain T3SS_needle_E PF08988.10 KOO53422.1 - 0.93 9.7 5.9 4.6 7.5 0.1 4.6 3 0 0 3 3 3 0 Type III secretion system, cytoplasmic E component of needle DUF4201 PF13870.6 KOO53422.1 - 1.5 8.5 5.5 5 6.8 0.1 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) AAA_22 PF13401.6 KOO53422.1 - 2.3 8.5 4.2 2.4 8.4 0.0 3.3 4 0 0 4 4 3 0 AAA domain DUF2505 PF10698.9 KOO53423.1 - 3e-09 37.2 0.0 3.5e-09 37.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) His_Phos_1 PF00300.22 KOO53424.1 - 5.3e-05 23.0 4.0 0.86 9.3 0.2 4.3 4 1 0 4 4 4 3 Histidine phosphatase superfamily (branch 1) Kinesin PF00225.23 KOO53425.1 - 1.6e-72 244.3 0.0 2.2e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOO53425.1 - 9.8e-12 45.0 0.0 4.5e-08 33.2 0.0 2.5 2 0 0 2 2 2 2 Microtubule binding LKAAEAR PF15478.6 KOO53425.1 - 0.092 13.0 0.0 0.28 11.5 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function with LKAAEAR motif DUF2285 PF10074.9 KOO53425.1 - 3.6 8.3 7.1 0.54 10.9 0.4 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2285) Complex1_LYR PF05347.15 KOO53426.1 - 0.016 15.2 0.1 0.096 12.7 0.1 2.1 2 0 0 2 2 2 0 Complex 1 protein (LYR family) C2 PF00168.30 KOO53427.1 - 1.9e-10 41.0 0.0 3e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 C2 domain Mobilization_B PF17511.2 KOO53429.1 - 0.29 11.5 1.7 1.3 9.4 0.5 2.2 2 0 0 2 2 2 0 Mobilization protein B Pex24p PF06398.11 KOO53430.1 - 0.052 12.5 0.1 0.052 12.5 0.1 1.8 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin Strabismus PF06638.11 KOO53430.1 - 0.083 11.5 0.1 0.11 11.1 0.1 1.2 1 0 0 1 1 1 0 Strabismus protein Reticulon PF02453.17 KOO53430.1 - 0.19 11.7 6.3 0.2 11.6 2.6 2.3 3 0 0 3 3 3 0 Reticulon Jiraiya PF15038.6 KOO53430.1 - 8.3 5.8 16.2 21 4.5 16.4 1.5 1 1 0 1 1 1 0 Jiraiya Mannitol_dh_C PF08125.13 KOO53431.1 - 0.006 16.1 0.3 1.5 8.3 0.0 2.6 2 1 0 2 2 2 2 Mannitol dehydrogenase C-terminal domain DUF4607 PF15380.6 KOO53431.1 - 0.083 12.4 0.2 0.16 11.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4607) rve PF00665.26 KOO53432.1 - 1.9e-12 47.4 0.0 4.2e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain COX15-CtaA PF02628.15 KOO53432.1 - 0.12 11.5 5.5 0.079 12.0 3.7 1.5 1 1 0 1 1 1 0 Cytochrome oxidase assembly protein Thioredoxin_14 PF18402.1 KOO53433.1 - 3.5e-12 46.8 0.0 5.2e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 KOO53433.1 - 0.0043 16.9 0.0 0.012 15.5 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin-like domain Glyco_transf_24 PF18404.1 KOO53434.1 - 4.2e-30 105.1 0.1 4.8e-30 104.9 0.1 1.0 1 0 0 1 1 1 1 Glucosyltransferase 24 FSH1 PF03959.13 KOO53435.1 - 1.8e-36 125.8 0.0 2.1e-36 125.6 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 KOO53435.1 - 0.0003 20.1 0.1 0.0053 16.0 0.0 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 KOO53435.1 - 0.00066 19.6 0.0 0.00083 19.2 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.18 KOO53435.1 - 0.012 15.1 0.0 0.036 13.6 0.0 1.6 1 1 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 KOO53435.1 - 0.035 14.7 3.0 1.4 9.5 2.7 2.1 1 1 1 2 2 2 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOO53435.1 - 0.036 13.5 0.0 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_4 PF08386.10 KOO53435.1 - 0.15 12.1 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein cobW PF02492.19 KOO53437.1 - 1.9e-52 177.4 0.4 3.2e-52 176.7 0.4 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KOO53437.1 - 1.2e-19 70.0 0.1 4e-19 68.3 0.1 1.9 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain EF-hand_7 PF13499.6 KOO53437.1 - 5.9e-08 33.1 1.9 2.4e-05 24.7 2.1 3.4 2 1 0 2 2 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO53437.1 - 8.5e-06 25.0 5.3 0.027 14.0 0.3 4.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KOO53437.1 - 1.4e-05 24.6 5.3 0.03 14.3 0.2 4.7 4 0 0 4 4 4 1 EF-hand domain RsgA_GTPase PF03193.16 KOO53437.1 - 0.00045 20.1 0.0 0.92 9.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase EF-hand_8 PF13833.6 KOO53437.1 - 0.00096 19.0 0.8 0.74 9.7 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO53437.1 - 0.0015 17.9 7.1 0.0077 15.7 0.3 3.7 4 0 0 4 4 4 1 EF hand AAA_23 PF13476.6 KOO53437.1 - 0.0055 17.2 0.1 0.018 15.5 0.1 1.8 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 KOO53437.1 - 0.01 16.3 0.0 0.035 14.6 0.0 1.9 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 KOO53437.1 - 0.027 14.8 0.2 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KOO53437.1 - 0.031 14.5 0.0 0.094 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOO53437.1 - 0.038 13.7 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 KOO53437.1 - 0.045 14.0 0.2 0.6 10.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 KOO53437.1 - 0.058 12.5 0.1 0.12 11.4 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein TsaE PF02367.17 KOO53437.1 - 0.071 13.1 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DAP3 PF10236.9 KOO53437.1 - 0.083 12.0 0.3 0.21 10.7 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_30 PF13604.6 KOO53437.1 - 0.1 12.3 0.3 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 KOO53437.1 - 0.13 11.7 0.3 9.1 5.8 0.1 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Dockerin_1 PF00404.18 KOO53437.1 - 0.27 11.4 2.0 11 6.3 0.0 3.4 3 0 0 3 3 3 0 Dockerin type I domain Sulfotransfer_3 PF13469.6 KOO53439.1 - 9.4e-05 22.9 0.5 0.13 12.6 0.5 2.3 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 KOO53439.1 - 0.00016 21.2 0.0 0.00026 20.5 0.0 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Macoilin PF09726.9 KOO53440.1 - 0.025 13.1 7.0 0.032 12.8 7.0 1.1 1 0 0 1 1 1 0 Macoilin family Bcr-Abl_Oligo PF09036.10 KOO53440.1 - 0.062 13.3 4.3 0.096 12.7 1.6 2.2 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Csm1_N PF18504.1 KOO53440.1 - 0.42 11.0 8.4 1.8 9.0 0.7 2.8 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF4201 PF13870.6 KOO53440.1 - 0.62 9.8 11.3 0.21 11.3 2.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) MerR-DNA-bind PF09278.11 KOO53440.1 - 0.65 10.6 25.4 0.24 12.0 6.4 3.3 2 2 2 4 4 4 0 MerR, DNA binding SlyX PF04102.12 KOO53440.1 - 1.9 9.2 15.2 3.6 8.3 3.0 2.8 2 1 1 3 3 3 0 SlyX YabA PF06156.13 KOO53440.1 - 2.9 8.6 7.9 0.4 11.4 1.7 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Atg14 PF10186.9 KOO53440.1 - 6.2 5.8 12.8 7.5 5.5 12.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 KOO53440.1 - 9.3 6.3 17.3 2.9 7.9 5.9 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 KOO53441.1 - 0.01 16.1 0.9 0.015 15.5 0.9 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Bcr-Abl_Oligo PF09036.10 KOO53441.1 - 0.061 13.3 1.4 0.15 12.1 0.3 2.0 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Spc7 PF08317.11 KOO53441.1 - 0.31 9.9 2.8 0.53 9.1 2.8 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein Totivirus_coat PF05518.11 KOO53441.1 - 6 4.8 6.2 7.2 4.5 6.2 1.1 1 0 0 1 1 1 0 Totivirus coat protein Ank_2 PF12796.7 KOO53442.1 - 2.9e-30 104.7 0.2 1.5e-07 31.9 0.0 4.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO53442.1 - 1.1e-25 86.8 5.5 0.0051 17.2 0.0 8.1 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.6 KOO53442.1 - 1.1e-23 83.3 3.8 6.9e-07 29.7 0.0 5.3 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO53442.1 - 7.2e-14 51.7 13.9 0.0016 18.7 0.1 7.1 3 3 5 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 KOO53442.1 - 2.8e-12 46.5 21.6 0.21 12.1 0.1 7.8 8 0 0 8 8 8 6 Ankyrin repeat Tubulin PF00091.25 KOO53444.1 - 3.7e-52 177.4 0.0 5e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOO53444.1 - 1.3e-09 38.3 0.1 2.1e-09 37.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KOO53444.1 - 0.0033 17.1 0.0 0.007 16.1 0.0 1.6 2 0 0 2 2 2 1 Tubulin domain EF-hand_6 PF13405.6 KOO53445.1 - 1.7e-39 130.4 6.7 2e-06 27.2 0.0 7.6 6 1 1 7 7 7 7 EF-hand domain EF-hand_1 PF00036.32 KOO53445.1 - 5.8e-39 128.7 12.6 5.4e-06 25.6 0.0 7.5 6 1 1 7 7 7 6 EF hand EF-hand_7 PF13499.6 KOO53445.1 - 1e-31 109.2 6.6 8.9e-10 38.9 0.2 4.1 3 1 2 5 5 5 5 EF-hand domain pair EF-hand_8 PF13833.6 KOO53445.1 - 6e-28 96.5 12.4 2.8e-06 27.1 0.3 6.5 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO53445.1 - 2.2e-20 71.2 12.7 0.0056 16.1 0.0 7.2 6 1 1 7 7 7 6 EF hand EF-hand_4 PF12763.7 KOO53445.1 - 3.6e-08 33.3 4.3 0.61 10.1 0.0 5.7 3 3 3 6 6 6 3 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KOO53445.1 - 0.0083 16.0 2.7 3 7.8 0.1 4.5 5 1 0 5 5 5 1 EF hand Toprim_2 PF13155.6 KOO53445.1 - 0.015 15.7 1.0 0.26 11.7 0.0 3.6 3 0 0 3 3 3 0 Toprim-like Caleosin PF05042.13 KOO53445.1 - 0.024 14.6 2.0 7.6 6.4 0.0 4.4 4 1 1 5 5 5 0 Caleosin related protein TFIIA PF03153.13 KOO53445.1 - 5 7.0 22.9 8 6.3 22.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Atg14 PF10186.9 KOO53445.1 - 5.9 5.9 29.9 11 5.0 29.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Solute_trans_a PF03619.16 KOO53447.1 - 6.9e-15 55.3 6.5 1.7e-14 54.0 6.5 1.6 1 1 0 1 1 1 1 Organic solute transporter Ostalpha K1 PF02960.14 KOO53447.1 - 0.8 9.8 4.9 0.24 11.5 1.6 1.8 2 0 0 2 2 2 0 K1 glycoprotein Aminotran_5 PF00266.19 KOO53449.1 - 9.9e-11 41.2 0.1 1.4e-10 40.7 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Tweety PF04906.13 KOO53451.1 - 0.47 9.1 6.5 0.084 11.5 0.5 2.1 2 0 0 2 2 2 0 Tweety Pox_P4A PF03395.14 KOO53453.1 - 0.18 9.3 0.0 0.19 9.2 0.0 1.0 1 0 0 1 1 1 0 Poxvirus P4A protein PIH1_CS PF18201.1 KOO53455.1 - 4.3e-11 43.1 0.0 8.2e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 PIH1 CS-like domain PIH1 PF08190.12 KOO53455.1 - 5.1e-09 35.8 0.0 1.5e-08 34.3 0.0 1.6 1 1 0 1 1 1 1 PIH1 N-terminal domain Keratin_2_head PF16208.5 KOO53457.1 - 0.67 10.1 12.5 12 6.0 12.5 2.0 1 1 0 1 1 1 0 Keratin type II head Histone PF00125.24 KOO53458.1 - 3.9e-54 182.5 2.0 4.4e-54 182.4 2.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KOO53458.1 - 0.00012 22.2 0.3 0.00022 21.3 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 KOO53458.1 - 0.00023 21.7 1.5 0.00028 21.5 1.5 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 KOO53458.1 - 0.00036 20.8 0.0 0.00055 20.3 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 KOO53458.1 - 0.0032 17.7 0.0 0.0062 16.8 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KOO53458.1 - 0.11 12.6 0.1 0.22 11.6 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit TPR_16 PF13432.6 KOO53459.1 - 0.0016 19.0 0.3 0.014 16.1 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOO53459.1 - 0.0034 17.9 0.0 0.012 16.1 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53459.1 - 0.046 14.5 0.1 0.62 11.0 0.1 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat PBP_N PF17093.5 KOO53459.1 - 0.23 11.7 0.1 0.23 11.7 0.1 2.4 2 0 0 2 2 2 0 Penicillin-binding protein N-terminus BRE1 PF08647.11 KOO53460.1 - 0.0013 18.7 1.1 0.0013 18.7 1.1 2.5 2 1 0 2 2 2 1 BRE1 E3 ubiquitin ligase YabA PF06156.13 KOO53460.1 - 1.8 9.3 8.5 0.17 12.5 0.6 2.6 3 0 0 3 3 3 0 Initiation control protein YabA Exostosin PF03016.15 KOO53461.1 - 0.00018 20.8 0.0 0.00024 20.5 0.0 1.2 1 0 0 1 1 1 1 Exostosin family UxuA PF03786.13 KOO53463.1 - 2.5e-131 437.7 0.0 3e-131 437.4 0.0 1.0 1 0 0 1 1 1 1 D-mannonate dehydratase (UxuA) AP_endonuc_2 PF01261.24 KOO53463.1 - 7.3e-07 28.8 0.0 2.5e-06 27.1 0.0 1.8 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel NanE PF04131.14 KOO53463.1 - 0.13 11.4 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase ApbA_C PF08546.11 KOO53463.1 - 0.16 12.2 0.6 5.7 7.2 0.0 2.8 4 0 0 4 4 4 0 Ketopantoate reductase PanE/ApbA C terminal DUF2465 PF10239.9 KOO53464.1 - 9.3e-31 107.2 0.0 2e-29 102.9 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2465) AvrE_T3Es PF11725.8 KOO53464.1 - 0.091 10.0 0.0 0.1 9.8 0.0 1.0 1 0 0 1 1 1 0 AvrE-family Type-III effector proteins (T3Es) CYSTM PF12734.7 KOO53464.1 - 4.7 7.6 5.4 0.54 10.6 0.3 2.0 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance LRR_6 PF13516.6 KOO53466.1 - 8.7e-16 56.6 14.8 0.0008 19.3 0.2 6.9 7 0 0 7 7 7 5 Leucine Rich repeat Skp1 PF01466.19 KOO53466.1 - 0.0007 19.7 0.0 0.0022 18.1 0.0 1.8 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_1 PF00560.33 KOO53466.1 - 0.0061 16.9 0.0 39 5.3 0.0 5.2 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO53466.1 - 0.0062 16.3 1.0 23 4.9 0.2 4.8 5 1 0 5 5 5 1 Leucine rich repeat LRR_4 PF12799.7 KOO53466.1 - 0.0091 16.4 3.5 2.9 8.4 0.0 4.4 5 1 0 5 5 5 1 Leucine Rich repeats (2 copies) ANAPC4_WD40 PF12894.7 KOO53467.1 - 1.3e-06 28.6 0.0 0.011 16.1 0.0 4.2 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOO53467.1 - 6.4e-06 26.8 1.5 20 6.3 0.0 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat PQQ_2 PF13360.6 KOO53467.1 - 7.2e-05 22.5 1.0 0.18 11.4 0.0 3.6 1 1 1 2 2 2 2 PQQ-like domain Cytochrom_D1 PF02239.16 KOO53467.1 - 0.072 11.6 0.0 3.4 6.1 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain PQQ PF01011.21 KOO53467.1 - 0.18 11.8 0.0 0.45 10.5 0.0 1.7 1 0 0 1 1 1 0 PQQ enzyme repeat Tudor-knot PF11717.8 KOO53468.1 - 6.5e-08 32.3 0.0 1.6e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF2960 PF11173.8 KOO53468.1 - 0.14 12.7 0.8 34 5.0 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2960) Rad60-SLD PF11976.8 KOO53472.1 - 3.3e-11 42.9 0.0 5e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOO53472.1 - 0.00063 19.4 0.0 0.00094 18.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family TUG-UBL1 PF11470.8 KOO53472.1 - 0.085 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 TUG ubiquitin-like domain Yae1_N PF09811.9 KOO53472.1 - 0.83 9.4 3.8 2.8 7.7 3.8 2.0 1 0 0 1 1 1 0 Essential protein Yae1, N terminal SAP PF02037.27 KOO53473.1 - 1.1e-09 37.8 1.2 3.6e-09 36.2 1.2 2.0 1 0 0 1 1 1 1 SAP domain DUF4088 PF13317.6 KOO53473.1 - 0.012 15.3 0.9 0.29 10.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4088) DUF2564 PF10819.8 KOO53473.1 - 0.022 15.1 0.8 4.3 7.8 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2564) Tcp11 PF05794.13 KOO53473.1 - 0.053 12.6 0.9 0.1 11.6 0.5 1.6 2 0 0 2 2 2 0 T-complex protein 11 CSN7a_helixI PF18392.1 KOO53473.1 - 0.12 12.3 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain DUF2203 PF09969.9 KOO53473.1 - 0.23 12.2 3.2 2.2 9.0 0.3 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Snapin_Pallidin PF14712.6 KOO53473.1 - 0.29 11.6 5.0 5.4 7.5 0.1 3.8 3 1 0 4 4 4 0 Snapin/Pallidin MukF_M PF17192.4 KOO53473.1 - 1.3 8.7 4.0 7.1 6.3 0.5 3.1 3 1 1 4 4 4 0 MukF middle domain Pkinase_Tyr PF07714.17 KOO53474.1 - 2.9e-32 112.0 0.0 3.8e-32 111.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO53474.1 - 5.2e-32 111.2 0.0 7.5e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOO53474.1 - 0.001 19.1 0.3 0.009 15.9 0.2 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family TIR_2 PF13676.6 KOO53474.1 - 0.0082 16.7 0.0 0.019 15.6 0.0 1.6 1 0 0 1 1 1 1 TIR domain Pkinase_fungal PF17667.1 KOO53474.1 - 0.035 12.9 0.0 0.06 12.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase TFIIE_beta PF02186.15 KOO53474.1 - 0.065 13.5 0.1 0.46 10.8 0.1 2.1 2 0 0 2 2 2 0 TFIIE beta subunit core domain Kinase-like PF14531.6 KOO53474.1 - 0.093 12.0 0.0 0.19 11.0 0.0 1.5 2 0 0 2 2 2 0 Kinase-like DUF1822 PF08852.11 KOO53474.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) TIR_2 PF13676.6 KOO53475.1 - 0.00069 20.2 0.0 0.0013 19.3 0.0 1.4 1 0 0 1 1 1 1 TIR domain DEAD PF00270.29 KOO53476.1 - 1.7e-06 27.9 0.0 5.3e-06 26.3 0.0 1.8 2 1 0 2 2 2 1 DEAD/DEAH box helicase T2SSF PF00482.23 KOO53476.1 - 0.0093 15.9 1.2 0.036 14.0 0.4 2.5 1 1 1 2 2 2 1 Type II secretion system (T2SS), protein F zf-C2HC_2 PF13913.6 KOO53477.1 - 1.5e-11 43.8 2.6 1.5e-11 43.8 2.6 3.7 4 0 0 4 4 4 2 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 KOO53477.1 - 2.9 8.5 6.3 4.8 7.8 0.2 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type Arm PF00514.23 KOO53480.1 - 0.00023 21.1 0.3 0.00023 21.1 0.3 2.5 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Choline_transpo PF04515.12 KOO53481.1 - 1.9e-57 194.9 15.5 1.9e-57 194.9 15.5 2.5 2 1 0 2 2 2 1 Plasma-membrane choline transporter Pkinase PF00069.25 KOO53483.1 - 6e-53 179.9 0.0 8.2e-53 179.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53483.1 - 5.3e-31 107.8 0.0 7.7e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOO53483.1 - 0.00027 20.9 0.4 0.38 10.6 0.1 3.0 2 1 1 3 3 3 2 Phosphotransferase enzyme family RCC1 PF00415.18 KOO53483.1 - 0.014 16.0 0.5 0.12 13.1 0.0 2.5 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat Pkinase_fungal PF17667.1 KOO53483.1 - 0.035 12.9 0.0 0.064 12.0 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase RCC1_2 PF13540.6 KOO53483.1 - 0.039 13.8 1.5 2.5 8.0 0.0 2.6 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat RepL PF05732.11 KOO53483.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) DEC-1_N PF04625.13 KOO53483.1 - 0.91 8.5 14.8 0.17 10.9 5.2 2.2 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region CAP_N PF01213.19 KOO53483.1 - 3.6 7.0 11.9 2.5 7.5 1.6 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Ribosomal_60s PF00428.19 KOO53483.1 - 4.2 8.0 11.4 13 6.4 11.4 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein HRDC PF00570.23 KOO53484.1 - 7.5e-05 22.7 0.0 0.00012 22.0 0.0 1.4 1 0 0 1 1 1 1 HRDC domain SWIM PF04434.17 KOO53484.1 - 0.049 13.3 0.2 0.1 12.3 0.2 1.5 1 0 0 1 1 1 0 SWIM zinc finger DUF1664 PF07889.12 KOO53485.1 - 3.2 7.8 6.2 2 8.5 0.3 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) CSD PF00313.22 KOO53486.1 - 0.00027 20.7 0.0 0.00043 20.1 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain MATH PF00917.26 KOO53486.1 - 0.0013 18.9 0.0 0.0023 18.1 0.0 1.3 1 0 0 1 1 1 1 MATH domain UBA PF00627.31 KOO53486.1 - 0.052 13.5 0.4 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 UBA/TS-N domain DNA_processg_A PF02481.15 KOO53487.1 - 9.7e-06 25.0 0.0 1.4e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 DNA recombination-mediator protein A S1_2 PF13509.6 KOO53487.1 - 0.16 12.0 0.0 0.57 10.3 0.0 1.8 2 0 0 2 2 2 0 S1 domain NAD_binding_1 PF00175.21 KOO53489.1 - 3.3e-27 95.3 0.0 6.9e-27 94.2 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOO53489.1 - 0.0045 17.3 0.0 0.01 16.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_9 PF08021.11 KOO53489.1 - 0.05 13.8 0.0 0.1 12.8 0.0 1.7 1 1 0 1 1 1 0 Siderophore-interacting FAD-binding domain FAD_binding_1 PF00667.20 KOO53489.1 - 0.077 12.5 0.0 6 6.4 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain NAD_binding_6 PF08030.12 KOO53489.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain EF-hand_1 PF00036.32 KOO53490.1 - 2.1e-48 158.3 5.6 7e-06 25.2 0.0 8.5 8 0 0 8 8 8 8 EF hand EF-hand_6 PF13405.6 KOO53490.1 - 2.9e-43 142.1 6.0 0.00018 21.2 0.0 8.5 8 0 0 8 8 8 8 EF-hand domain EF-hand_7 PF13499.6 KOO53490.1 - 3.3e-36 123.6 12.5 5.4e-07 30.0 0.0 7.9 5 2 0 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.6 KOO53490.1 - 3.5e-29 99.0 11.1 0.00024 20.4 0.0 8.6 8 0 0 8 8 8 8 EF hand EF-hand_8 PF13833.6 KOO53490.1 - 7.7e-18 64.1 11.1 0.00096 19.0 0.1 8.0 7 1 1 8 8 8 4 EF-hand domain pair EF-hand_4 PF12763.7 KOO53490.1 - 4.1e-08 33.1 4.2 3.3 7.7 0.1 6.5 4 3 3 7 7 7 3 Cytoskeletal-regulatory complex EF hand Toprim_2 PF13155.6 KOO53490.1 - 0.00011 22.5 4.3 4.1 7.9 0.0 6.5 5 3 2 7 7 7 1 Toprim-like MPS2 PF17060.5 KOO53490.1 - 0.0024 17.2 3.1 1.3 8.2 0.0 4.6 5 1 0 5 5 5 1 Monopolar spindle protein 2 EF-hand_9 PF14658.6 KOO53490.1 - 0.086 13.2 0.1 28 5.1 0.0 3.7 4 0 0 4 4 4 0 EF-hand domain RCDG1 PF15725.5 KOO53490.1 - 0.72 10.3 4.1 3.5 8.1 4.1 2.2 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein DUF2939 PF11159.8 KOO53491.1 - 0.0029 18.0 0.0 0.063 13.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2939) GFO_IDH_MocA PF01408.22 KOO53492.1 - 5.3e-06 27.3 0.0 9.1e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Endonuclease_1 PF04231.13 KOO53493.1 - 4.4e-36 124.7 0.1 1.1e-35 123.4 0.1 1.6 1 1 0 1 1 1 1 Endonuclease I Homeodomain PF00046.29 KOO53494.1 - 2e-15 56.4 2.8 3.2e-15 55.7 2.8 1.3 1 0 0 1 1 1 1 Homeodomain WD40 PF00400.32 KOO53496.1 - 1.3e-69 228.3 27.3 2.3e-09 37.7 0.2 7.6 8 0 0 8 8 8 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO53496.1 - 7.9e-21 74.4 7.9 0.012 14.6 0.0 7.1 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOO53496.1 - 2.1e-18 65.8 4.8 0.36 10.8 0.0 7.4 7 0 0 7 7 7 7 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 KOO53496.1 - 2.1e-17 63.2 5.0 0.011 16.0 0.1 6.9 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KOO53496.1 - 6.9e-10 37.9 0.0 0.25 9.6 0.0 5.1 1 1 2 4 4 4 3 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 KOO53496.1 - 8.9e-07 28.5 2.8 1.1 8.5 0.0 5.1 3 2 2 5 5 5 3 WD40-like domain Osteoregulin PF07175.11 KOO53496.1 - 2.6e-05 24.5 1.8 8.3 6.6 0.0 5.3 3 1 3 6 6 6 1 Osteoregulin DUF4875 PF16175.5 KOO53496.1 - 0.0025 17.9 9.1 7.4 6.7 0.0 6.3 1 1 6 7 7 7 1 Domain of unknown function (DUF4875) dsrm PF00035.26 KOO53496.1 - 0.0043 17.7 3.0 63 4.4 0.0 5.5 7 0 0 7 7 7 0 Double-stranded RNA binding motif WD40_3 PF15911.5 KOO53496.1 - 0.023 14.7 1.7 1.3e+02 2.7 0.0 5.5 6 0 0 6 6 6 0 WD domain, G-beta repeat Dfp1_Him1_M PF08630.10 KOO53496.1 - 0.49 10.6 8.1 42 4.4 0.1 4.7 5 1 0 5 5 5 0 Dfp1/Him1, central region FAST_1 PF06743.15 KOO53497.1 - 3.3e-19 68.6 0.0 0.043 13.8 0.0 8.3 1 1 9 10 10 10 8 FAST kinase-like protein, subdomain 1 DUF1601 PF07671.11 KOO53497.1 - 7.2e-18 64.2 17.4 0.36 10.7 0.1 10.4 10 0 0 10 10 10 6 Protein of unknown function (DUF1601) RsdA_SigD_bd PF16751.5 KOO53497.1 - 0.00016 21.9 36.9 2.6 8.4 0.2 9.1 9 0 0 9 9 9 3 Anti-sigma-D factor RsdA to sigma factor binding region Nucleotid_trans PF03407.16 KOO53497.1 - 0.06 13.3 0.9 0.99 9.3 0.7 2.9 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase DUF2525 PF10733.9 KOO53497.1 - 0.14 12.5 19.1 62 4.0 0.0 7.7 1 1 8 9 9 9 0 Protein of unknown function (DUF2525) NTP_transf_9 PF04248.12 KOO53497.1 - 0.57 10.1 27.7 31 4.5 0.2 8.0 8 0 0 8 8 8 0 Domain of unknown function (DUF427) CTP_transf_3 PF02348.19 KOO53498.1 - 5e-31 108.3 0.0 6.1e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 KOO53498.1 - 7.5e-07 29.6 0.0 1.1e-06 29.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain HEAT_2 PF13646.6 KOO53499.1 - 0.039 14.3 1.4 2.6 8.5 0.2 3.4 2 1 1 3 3 3 0 HEAT repeats RRM_1 PF00076.22 KOO53499.1 - 0.083 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cellulase PF00150.18 KOO53501.1 - 8e-34 117.3 0.0 9.4e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Cellulase PF00150.18 KOO53502.1 - 1.5e-08 34.4 0.0 2e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF3025 PF11227.8 KOO53502.1 - 0.11 12.2 0.1 0.26 11.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3025) CdvA PF18822.1 KOO53503.1 - 0.004 17.0 6.8 0.004 17.0 6.8 2.1 2 0 0 2 2 2 1 CdvA-like coiled-coil domain LOH1CR12 PF10158.9 KOO53503.1 - 0.13 12.2 3.0 0.36 10.9 3.0 1.7 1 0 0 1 1 1 0 Tumour suppressor protein FAM76 PF16046.5 KOO53503.1 - 0.14 11.5 9.2 0.021 14.2 2.5 2.1 2 0 0 2 2 2 0 FAM76 protein Sigma70_r3 PF04539.16 KOO53503.1 - 1.5 9.0 9.9 1 9.5 0.1 3.6 1 1 3 4 4 4 0 Sigma-70 region 3 LRR_1 PF00560.33 KOO53504.1 - 2.3e-05 24.3 11.5 3.1 8.7 0.0 7.9 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 KOO53504.1 - 0.00052 19.9 15.0 33 4.9 0.0 8.0 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.7 KOO53504.1 - 0.001 19.4 6.5 7.4 7.2 0.3 5.6 2 1 6 8 8 8 2 Leucine Rich repeats (2 copies) Homoserine_dh PF00742.19 KOO53505.1 - 3e-33 115.2 0.0 5e-33 114.5 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 KOO53505.1 - 1.8e-06 28.6 0.4 1.4e-05 25.7 0.4 2.4 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain TPT PF03151.16 KOO53506.1 - 1.4e-47 162.4 7.5 2e-47 161.9 7.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOO53506.1 - 5.6e-06 26.6 32.8 0.00029 21.0 12.9 2.6 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 KOO53506.1 - 7.8e-05 22.0 9.1 0.0075 15.5 7.2 3.0 2 1 0 2 2 2 1 UAA transporter family Atg14 PF10186.9 KOO53506.1 - 0.003 16.7 0.8 0.004 16.3 0.8 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Nuc_sug_transp PF04142.15 KOO53506.1 - 0.03 13.5 2.6 0.29 10.3 0.1 2.2 1 1 0 2 2 2 0 Nucleotide-sugar transporter Cep57_CLD_2 PF14197.6 KOO53506.1 - 4.8 7.3 14.9 3.9 7.6 2.2 2.6 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 GREB1 PF15782.5 KOO53506.1 - 6.4 3.8 7.1 8.4 3.4 7.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF572 PF04502.13 KOO53506.1 - 7.5 6.1 7.8 9.5 5.7 7.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF1043 PF06295.12 KOO53506.1 - 9.8 6.2 8.4 6.3 6.8 1.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) Hist_deacetyl PF00850.19 KOO53507.1 - 3.7e-78 263.1 0.0 4.5e-78 262.8 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Auxin_repressed PF05564.12 KOO53507.1 - 0.0037 17.9 0.0 0.02 15.6 0.0 2.0 2 0 0 2 2 2 1 Dormancy/auxin associated protein DUF2098 PF09871.9 KOO53508.1 - 0.051 13.9 0.2 0.082 13.3 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) zf-C4H2 PF10146.9 KOO53508.1 - 0.11 12.9 0.9 0.13 12.6 0.9 1.0 1 0 0 1 1 1 0 Zinc finger-containing protein Thioredoxin PF00085.20 KOO53509.1 - 1.7e-06 28.0 0.0 2.5e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Aldedh PF00171.22 KOO53510.1 - 5.9e-37 127.3 3.6 1.3e-19 70.0 1.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family zf-H2C2_2 PF13465.6 KOO53511.1 - 1.3e-26 91.8 46.8 1e-05 25.7 0.8 7.0 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 KOO53511.1 - 9e-26 88.9 44.8 0.00016 21.9 1.7 6.4 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOO53511.1 - 1e-20 72.6 38.7 0.0052 17.5 0.8 6.4 6 0 0 6 6 6 6 C2H2-type zinc finger CHORD PF04968.12 KOO53511.1 - 0.00093 19.9 36.5 3.5 8.4 0.8 6.3 2 1 4 6 6 6 6 CHORD MORN_2 PF07661.13 KOO53511.1 - 0.0045 17.1 0.1 84 3.9 0.0 4.9 5 0 0 5 5 5 0 MORN repeat variant zf-C2H2_aberr PF17017.5 KOO53511.1 - 0.013 15.6 23.3 0.18 11.9 1.2 5.8 2 1 4 6 6 6 0 Aberrant zinc-finger zf-C2H2_11 PF16622.5 KOO53511.1 - 8.1 6.3 28.8 0.5 10.2 1.9 5.6 6 0 0 6 6 6 0 zinc-finger C2H2-type META PF03724.16 KOO53512.1 - 0.087 12.8 0.5 0.15 12.0 0.5 1.4 1 0 0 1 1 1 0 META domain Sporozoite_P67 PF05642.11 KOO53514.1 - 0.19 9.8 2.8 0.23 9.5 2.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Complex1_49kDa PF00346.19 KOO53515.1 - 4e-125 416.4 0.0 5.1e-125 416.0 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 KOO53515.1 - 0.034 13.0 0.0 0.062 12.2 0.0 1.4 1 0 0 1 1 1 0 Nickel-dependent hydrogenase adh_short_C2 PF13561.6 KOO53517.1 - 8.8e-05 22.2 0.1 0.00014 21.5 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOO53517.1 - 0.0026 17.3 0.0 0.0035 16.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Synaptobrevin PF00957.21 KOO53518.1 - 0.25 11.2 3.0 0.87 9.4 3.0 1.9 1 0 0 1 1 1 0 Synaptobrevin CDRT4 PF15213.6 KOO53518.1 - 0.8 10.3 3.3 1.3 9.6 0.2 2.4 2 1 0 2 2 2 0 CMT1A duplicated region transcript 4 protein UPF0184 PF03670.13 KOO53518.1 - 2.8 8.4 12.1 4 7.9 0.3 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) Occludin_ELL PF07303.13 KOO53518.1 - 7.2 7.4 15.3 0.23 12.2 0.4 3.2 3 0 0 3 3 3 0 Occludin homology domain LMP PF04778.12 KOO53519.1 - 0.01 15.8 0.7 0.011 15.7 0.7 1.1 1 0 0 1 1 1 0 LMP repeated region Methyltransf_21 PF05050.12 KOO53520.1 - 5.4e-16 59.1 0.0 9.4e-10 38.8 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase FkbM domain Methyltransf_22 PF13383.6 KOO53520.1 - 0.00019 21.1 0.0 0.0003 20.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO53520.1 - 0.0063 17.2 0.0 0.024 15.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO53520.1 - 0.0079 16.9 0.0 0.024 15.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ABC_tran PF00005.27 KOO53521.1 - 1.5e-37 129.2 0.0 1.3e-19 71.1 0.0 4.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOO53521.1 - 8.1e-16 58.7 0.0 0.00018 21.4 0.1 4.1 3 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOO53521.1 - 6e-10 38.9 0.1 0.063 12.7 0.0 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOO53521.1 - 5.8e-08 33.5 0.0 0.0015 19.0 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_15 PF13175.6 KOO53521.1 - 7.5e-07 29.2 2.9 0.085 12.6 0.0 3.9 4 0 0 4 4 4 2 AAA ATPase domain AAA_29 PF13555.6 KOO53521.1 - 9.3e-05 22.1 0.1 0.14 11.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 KOO53521.1 - 0.00011 22.5 0.0 0.58 10.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 KOO53521.1 - 0.00012 22.2 0.2 0.34 11.2 0.0 3.9 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 KOO53521.1 - 0.00029 20.9 0.0 0.56 10.3 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase 4HB PF17947.1 KOO53521.1 - 0.018 15.1 0.1 0.28 11.2 0.0 2.8 2 0 0 2 2 2 0 Four helical bundle domain DLIC PF05783.11 KOO53521.1 - 0.018 13.9 0.0 1.2 7.8 0.0 2.2 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) AAA PF00004.29 KOO53521.1 - 0.031 14.7 0.0 3.5 8.1 0.0 3.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CLP1_P PF16575.5 KOO53521.1 - 0.041 13.7 0.1 1.6 8.5 0.0 3.0 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_28 PF13521.6 KOO53521.1 - 0.052 13.8 0.0 4.8 7.4 0.0 2.9 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 KOO53521.1 - 0.092 12.6 0.0 1.3 8.9 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 KOO53521.1 - 0.11 12.6 0.0 9 6.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KOO53521.1 - 0.13 12.6 0.0 13 6.2 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_13 PF13166.6 KOO53521.1 - 0.75 8.4 6.2 25 3.3 0.0 3.6 3 1 0 3 3 3 0 AAA domain Myosin_head PF00063.21 KOO53522.1 - 1.2e-11 43.6 0.0 1.8e-09 36.4 0.0 2.3 2 0 0 2 2 2 2 Myosin head (motor domain) AAA_16 PF13191.6 KOO53522.1 - 0.0038 17.6 0.1 0.0038 17.6 0.1 3.2 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 KOO53522.1 - 0.008 16.4 0.0 0.037 14.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOO53522.1 - 0.18 11.8 0.0 0.45 10.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Med3 PF11593.8 KOO53523.1 - 4.6 6.3 5.7 5.1 6.2 5.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal bZIP_1 PF00170.21 KOO53524.1 - 8.9e-05 22.5 3.8 0.088 12.9 0.7 2.7 1 1 1 2 2 2 2 bZIP transcription factor DASH_Dam1 PF08653.10 KOO53524.1 - 0.0002 21.1 3.4 1.3 8.9 0.2 3.5 1 1 2 3 3 3 3 DASH complex subunit Dam1 TMF_DNA_bd PF12329.8 KOO53524.1 - 0.00027 20.9 2.3 0.15 12.1 0.2 2.7 1 1 1 2 2 2 2 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 KOO53524.1 - 0.00039 19.4 6.4 0.00054 18.9 6.4 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF2730 PF10805.8 KOO53524.1 - 0.0015 18.6 2.3 0.13 12.3 2.2 3.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2730) ATG16 PF08614.11 KOO53524.1 - 0.0016 18.7 4.2 0.0019 18.5 4.2 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Ax_dynein_light PF10211.9 KOO53524.1 - 0.0045 17.0 6.7 0.21 11.5 0.4 2.1 1 1 1 2 2 2 2 Axonemal dynein light chain DUF724 PF05266.14 KOO53524.1 - 0.0075 16.1 4.3 0.019 14.8 4.3 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF724) Fez1 PF06818.15 KOO53524.1 - 0.011 16.2 3.8 0.013 16.0 3.8 1.1 1 0 0 1 1 1 0 Fez1 DUF4472 PF14739.6 KOO53524.1 - 0.012 16.3 4.3 0.012 16.3 4.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4472) CENP-H PF05837.12 KOO53524.1 - 0.014 15.8 1.7 0.024 15.1 1.7 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) GrpE PF01025.19 KOO53524.1 - 0.025 14.2 11.1 0.55 9.9 5.0 2.1 1 1 1 2 2 2 0 GrpE PI3K_P85_iSH2 PF16454.5 KOO53524.1 - 0.043 13.4 8.6 0.021 14.4 5.2 2.2 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FAM76 PF16046.5 KOO53524.1 - 0.075 12.4 0.2 0.086 12.2 0.2 1.2 1 0 0 1 1 1 0 FAM76 protein YabA PF06156.13 KOO53524.1 - 0.088 13.5 6.4 0.43 11.2 5.4 2.3 1 1 0 1 1 1 0 Initiation control protein YabA TMCO5 PF14992.6 KOO53524.1 - 0.11 12.1 6.7 0.12 11.9 6.7 1.2 1 0 0 1 1 1 0 TMCO5 family AAA_13 PF13166.6 KOO53524.1 - 0.12 11.0 4.7 0.14 10.7 4.7 1.2 1 0 0 1 1 1 0 AAA domain ZapB PF06005.12 KOO53524.1 - 0.13 12.8 10.9 1.7 9.2 2.5 2.5 1 1 1 2 2 2 0 Cell division protein ZapB APG6_N PF17675.1 KOO53524.1 - 0.15 12.5 20.2 4.1 7.9 20.1 2.4 1 1 0 1 1 1 0 Apg6 coiled-coil region KASH_CCD PF14662.6 KOO53524.1 - 0.16 11.8 11.5 0.19 11.5 11.5 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 KOO53524.1 - 0.19 11.0 6.8 0.38 10.1 6.8 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Cnn_1N PF07989.11 KOO53524.1 - 0.22 11.7 4.0 0.15 12.3 1.2 2.2 2 1 0 2 2 1 0 Centrosomin N-terminal motif 1 Mod_r PF07200.13 KOO53524.1 - 0.22 11.6 3.2 0.15 12.2 0.7 1.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TMPIT PF07851.13 KOO53524.1 - 0.23 10.6 0.5 0.26 10.5 0.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein Seryl_tRNA_N PF02403.22 KOO53524.1 - 0.24 11.6 10.5 0.22 11.7 3.9 2.9 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FlaC_arch PF05377.11 KOO53524.1 - 0.25 11.8 14.8 1.1 9.7 3.6 3.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF812 PF05667.11 KOO53524.1 - 0.3 9.9 10.6 0.37 9.6 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Tektin PF03148.14 KOO53524.1 - 0.49 9.1 6.2 1.1 7.9 0.4 2.2 1 1 1 2 2 2 0 Tektin family ACCA PF03255.14 KOO53524.1 - 0.74 9.7 5.6 2.2 8.2 4.3 2.3 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ABC_tran_CTD PF16326.5 KOO53524.1 - 0.76 10.1 41.3 2.1 8.7 14.9 3.8 1 1 2 3 3 2 0 ABC transporter C-terminal domain TMF_TATA_bd PF12325.8 KOO53524.1 - 0.81 9.9 12.0 5.9 7.1 12.0 2.1 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Spc24 PF08286.11 KOO53524.1 - 1 9.6 6.8 28 5.0 6.8 2.4 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF5331 PF17265.2 KOO53524.1 - 1.2 8.9 4.0 28 4.5 3.7 2.6 1 1 0 1 1 1 0 Family of unknown function (DUF5331) M PF02370.16 KOO53524.1 - 1.3 9.8 12.1 1.5e+02 3.5 0.3 5.4 2 2 4 6 6 6 0 M protein repeat CENP-F_leu_zip PF10473.9 KOO53524.1 - 1.4 8.9 13.1 2.2 8.3 13.1 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.19 KOO53524.1 - 1.8 8.3 21.2 2.1 8.1 21.2 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF2203 PF09969.9 KOO53524.1 - 2.5 8.8 6.7 18 6.1 6.7 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) bZIP_2 PF07716.15 KOO53524.1 - 4.9 7.3 8.8 12 6.1 1.3 3.1 1 1 3 4 4 4 0 Basic region leucine zipper CD225 PF04505.12 KOO53525.1 - 0.038 14.1 1.7 0.062 13.4 1.7 1.4 1 1 0 1 1 1 0 Interferon-induced transmembrane protein EF-hand_6 PF13405.6 KOO53526.1 - 0.0013 18.4 0.2 0.0022 17.8 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KOO53526.1 - 0.0025 17.2 0.9 0.004 16.6 0.9 1.4 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO53526.1 - 0.0078 15.7 1.3 0.012 15.1 1.3 1.3 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO53526.1 - 0.014 15.8 0.1 0.017 15.6 0.1 1.1 1 0 0 1 1 1 0 EF-hand domain pair DUF3918 PF13056.6 KOO53526.1 - 0.091 12.4 0.8 0.14 11.8 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) E1_UFD PF09358.10 KOO53527.1 - 0.15 12.8 0.1 12 6.7 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin fold domain EF-hand_1 PF00036.32 KOO53528.1 - 1.3e-09 36.9 0.7 0.00029 20.2 0.1 4.7 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.6 KOO53528.1 - 4.7e-06 26.1 0.1 0.01 15.7 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO53528.1 - 3e-05 24.4 1.4 0.0039 17.6 0.2 3.2 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO53528.1 - 0.0019 17.6 2.2 0.031 13.8 0.2 3.5 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 KOO53528.1 - 0.041 13.7 0.2 0.18 11.6 0.2 2.2 1 1 0 1 1 1 0 EF-hand domain pair UQ_con PF00179.26 KOO53531.1 - 3.1e-20 72.3 0.0 4.1e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Na_Ca_ex PF01699.24 KOO53532.1 - 7.3e-37 126.6 44.5 3.6e-20 72.5 15.0 2.7 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Calx-beta PF03160.14 KOO53532.1 - 2.5e-19 69.3 2.2 6e-17 61.7 0.9 2.3 2 0 0 2 2 2 2 Calx-beta domain DUF5079 PF16882.5 KOO53532.1 - 0.031 14.2 0.2 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5079) TP6A_N PF04406.14 KOO53533.1 - 2.6e-20 72.1 0.1 4.9e-20 71.3 0.1 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase MoaC PF01967.21 KOO53534.1 - 1.1e-54 184.3 4.4 1.2e-54 184.1 4.4 1.0 1 0 0 1 1 1 1 MoaC family BASP1 PF05466.12 KOO53535.1 - 7.3 6.5 12.3 8.1 6.4 12.3 1.1 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) gag_pre-integrs PF13976.6 KOO53536.1 - 1.5e-06 27.9 0.1 4.2e-06 26.5 0.0 1.8 2 0 0 2 2 2 1 GAG-pre-integrase domain rve PF00665.26 KOO53536.1 - 0.0011 19.2 0.0 0.0035 17.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain PepSY_TM_like_2 PF16357.5 KOO53536.1 - 0.036 14.0 0.2 0.083 12.9 0.2 1.5 1 0 0 1 1 1 0 Putative PepSY_TM-like OrsD PF12013.8 KOO53536.1 - 0.55 10.7 2.5 2.5 8.6 0.4 2.5 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D Glyco_hydro_2 PF00703.21 KOO53537.1 - 3.7e-05 24.4 0.0 7.8e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 KOO53537.1 - 0.0013 18.7 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain PAN_4 PF14295.6 KOO53537.1 - 0.067 13.1 0.9 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 PAN domain ETS_PEA3_N PF04621.13 KOO53538.1 - 0.24 11.2 0.0 0.3 10.9 0.0 1.2 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain PAE PF03283.13 KOO53539.1 - 3.6e-59 200.7 0.0 4.8e-59 200.3 0.0 1.1 1 0 0 1 1 1 1 Pectinacetylesterase Glyco_hydro_2_C PF02836.17 KOO53539.1 - 0.001 18.2 0.0 0.017 14.2 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_65N PF03636.15 KOO53540.1 - 0.25 10.9 1.0 0.44 10.1 1.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Borrelia_P83 PF05262.11 KOO53540.1 - 3.7 5.9 10.3 4.6 5.6 10.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SHIPPO-rpt PF07004.12 KOO53541.1 - 0.001 19.9 3.6 3.1 8.9 0.0 4.7 4 0 0 4 4 4 2 Sperm-tail PG-rich repeat EF-hand_1 PF00036.32 KOO53542.1 - 3.3e-05 23.1 0.1 6.1e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOO53542.1 - 7.9e-05 22.3 0.1 0.00017 21.3 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KOO53542.1 - 0.0038 16.7 0.1 0.0071 15.8 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO53542.1 - 0.0053 17.2 0.0 0.0093 16.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair Glyco_transf_20 PF00982.21 KOO53544.1 - 3.9e-103 345.7 0.0 5.4e-103 345.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOO53544.1 - 6.9e-36 123.5 0.0 1.1e-35 122.8 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase TPR_19 PF14559.6 KOO53545.1 - 2.3e-09 37.6 22.6 0.00022 21.7 4.4 4.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOO53545.1 - 0.005 16.9 13.0 0.24 11.6 0.5 4.6 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO53545.1 - 0.017 15.7 3.2 0.017 15.7 3.2 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat RPN7 PF10602.9 KOO53545.1 - 0.018 14.8 0.1 0.15 11.8 0.0 2.2 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_11 PF13414.6 KOO53545.1 - 0.019 14.7 2.4 0.55 10.0 0.2 3.1 4 0 0 4 4 4 0 TPR repeat TPR_1 PF00515.28 KOO53545.1 - 0.067 13.0 4.0 3.8 7.5 0.1 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53545.1 - 0.093 13.0 1.0 0.49 10.7 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOO53545.1 - 0.27 11.4 17.5 0.17 12.0 0.8 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53545.1 - 0.29 12.1 28.6 0.063 14.1 3.7 6.0 5 2 3 8 8 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO53545.1 - 1 9.6 8.7 12 6.3 0.6 3.5 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KOO53545.1 - 1.1 9.4 14.0 5.6 7.2 2.3 5.1 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53545.1 - 4.5 7.6 17.2 1.3 9.4 1.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOO53545.1 - 5.3 8.0 14.8 0.14 12.9 4.8 3.8 4 1 0 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO53545.1 - 7.5 7.4 12.6 1.7 9.5 1.5 4.1 5 0 0 5 5 3 0 Tetratricopeptide repeat K_channel_TID PF07941.11 KOO53546.1 - 0.039 14.4 4.2 0.1 13.1 4.2 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Pkinase PF00069.25 KOO53547.1 - 2e-42 145.4 0.0 2.4e-42 145.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53547.1 - 1.2e-32 113.2 0.0 1.5e-32 113.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO53547.1 - 6.8e-06 25.1 0.0 9.6e-06 24.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase MOZART1 PF12554.8 KOO53547.1 - 0.071 12.9 0.1 1.1 9.1 0.1 2.2 2 0 0 2 2 2 0 Mitotic-spindle organizing gamma-tubulin ring associated IlvN PF07991.12 KOO53547.1 - 0.093 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ABC1 PF03109.16 KOO53547.1 - 0.13 12.4 0.0 0.55 10.4 0.1 2.0 2 0 0 2 2 2 0 ABC1 family APH PF01636.23 KOO53547.1 - 0.16 11.8 3.9 0.26 11.2 3.9 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KOO53547.1 - 0.19 11.0 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Flot PF15975.5 KOO53548.1 - 0.51 10.5 6.6 6.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Flotillin Astro_capsid_p PF12226.8 KOO53549.1 - 0.88 8.7 4.4 1 8.4 4.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Pkinase PF00069.25 KOO53550.1 - 6.5e-43 147.0 0.0 3e-42 144.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53550.1 - 1.1e-18 67.5 0.0 1.6e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SPRY PF00622.28 KOO53551.1 - 0.18 12.0 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 SPRY domain MAGE_N PF12440.8 KOO53551.1 - 1.3 9.7 3.9 1.4 9.6 2.5 1.8 1 1 0 1 1 1 0 Melanoma associated antigen family N terminal TylF PF05711.11 KOO53553.1 - 7.1e-08 32.1 0.0 8.9e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) DUF4218 PF13960.6 KOO53555.1 - 0.022 14.4 0.3 0.041 13.5 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) DUF4248 PF14053.6 KOO53555.1 - 0.11 12.5 0.0 0.41 10.7 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) PGM_PMM_I PF02878.16 KOO53557.1 - 3.6e-28 98.0 0.0 7.1e-28 97.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 KOO53557.1 - 1.3e-23 83.3 0.0 3e-23 82.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 KOO53557.1 - 1.3e-09 38.5 0.1 4e-09 37.0 0.1 1.8 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 KOO53557.1 - 1.4e-05 25.2 0.0 3.6e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Dpy-30 PF05186.13 KOO53557.1 - 0.0046 16.6 0.4 0.015 15.0 0.1 2.1 2 0 0 2 2 2 1 Dpy-30 motif Dpy-30 PF05186.13 KOO53558.1 - 7.3e-05 22.4 0.3 0.0022 17.7 0.0 2.8 3 0 0 3 3 3 1 Dpy-30 motif Collagen PF01391.18 KOO53558.1 - 0.004 16.9 6.9 0.0068 16.1 6.9 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) RIIa PF02197.17 KOO53558.1 - 0.013 15.2 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit PRA1 PF03208.19 KOO53559.1 - 9e-25 87.0 1.9 1.1e-24 86.7 1.9 1.0 1 0 0 1 1 1 1 PRA1 family protein PI-PLC-C1 PF16670.5 KOO53560.1 - 0.00017 20.8 0.0 0.0005 19.2 0.0 1.7 1 1 0 1 1 1 1 Phosphoinositide phospholipase C, Ca2+-dependent PI-PLC-X PF00388.19 KOO53560.1 - 0.015 14.9 0.0 0.041 13.5 0.0 1.7 1 1 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain ANAPC4_WD40 PF12894.7 KOO53561.1 - 8.5e-12 45.2 0.1 0.00062 20.0 0.0 5.2 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOO53561.1 - 1.8e-09 38.1 0.7 2 9.4 0.0 7.1 6 1 1 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 KOO53561.1 - 6.8e-08 32.6 0.0 0.043 13.7 0.0 4.9 3 2 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 KOO53561.1 - 0.00038 18.6 0.2 1.4 6.8 0.1 3.7 2 2 1 3 3 3 3 IKI3 family Proteasome_A_N PF10584.9 KOO53561.1 - 0.00072 19.2 0.6 2.4 7.9 0.0 4.1 3 0 0 3 3 3 2 Proteasome subunit A N-terminal signature PD40 PF07676.12 KOO53561.1 - 0.076 13.0 0.0 8.1 6.5 0.0 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Capsule_synth PF05159.14 KOO53562.1 - 0.0021 17.6 0.0 0.003 17.1 0.0 1.2 1 0 0 1 1 1 1 Capsule polysaccharide biosynthesis protein TIG PF01833.24 KOO53563.1 - 5.1e-15 55.3 0.1 1.8e-11 44.0 0.2 3.9 3 0 0 3 3 3 2 IPT/TIG domain Glyco_transf_49 PF13896.6 KOO53564.1 - 1.8e-22 80.1 0.2 1.3e-19 70.8 0.1 2.8 1 1 0 2 2 2 2 Glycosyl-transferase for dystroglycan NAP PF00956.18 KOO53565.1 - 8.7e-33 113.6 0.0 2e-32 112.5 0.0 1.5 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) DUF3322 PF11795.8 KOO53565.1 - 0.049 13.6 0.6 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Exostosin PF03016.15 KOO53566.1 - 1.1e-17 64.2 0.1 1.5e-17 63.7 0.1 1.2 1 0 0 1 1 1 1 Exostosin family zf-C2HC_2 PF13913.6 KOO53567.1 - 1.6e-16 59.7 8.5 1.1e-08 34.8 0.4 2.5 2 0 0 2 2 2 2 zinc-finger of a C2HC-type Ion_trans PF00520.31 KOO53567.1 - 3.7e-14 52.5 6.6 5.5e-14 52.0 6.6 1.2 1 0 0 1 1 1 1 Ion transport protein C2 PF00168.30 KOO53567.1 - 1e-12 48.2 0.0 2.2e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain cNMP_binding PF00027.29 KOO53567.1 - 0.0001 22.3 0.0 0.00019 21.5 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain zf-CpG_bind_C PF12269.8 KOO53567.1 - 0.0003 20.7 7.3 0.00073 19.4 1.1 2.5 1 1 1 2 2 2 1 CpG binding protein zinc finger C terminal domain zf-C2H2_4 PF13894.6 KOO53567.1 - 0.00048 20.7 0.3 1.1 10.3 0.0 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KOO53567.1 - 0.0036 17.0 1.2 1.6 8.6 0.0 2.5 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2 PF00096.26 KOO53567.1 - 0.0049 17.2 0.6 2.2 8.9 0.0 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type DUF3418 PF11898.8 KOO53567.1 - 0.0092 14.7 1.5 0.11 11.1 1.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3418) zf-BED PF02892.15 KOO53567.1 - 0.054 13.5 0.1 8.7 6.5 0.1 2.6 2 0 0 2 2 2 0 BED zinc finger Ion_trans_2 PF07885.16 KOO53567.1 - 0.073 13.0 0.7 0.19 11.7 0.7 1.7 1 0 0 1 1 1 0 Ion channel Sulfotransfer_1 PF00685.27 KOO53567.1 - 0.32 10.4 4.3 2.1 7.8 2.0 2.4 2 0 0 2 2 2 0 Sulfotransferase domain FYVE PF01363.21 KOO53567.1 - 0.38 10.9 2.7 19 5.5 0.3 2.5 2 0 0 2 2 2 0 FYVE zinc finger zf-RING_7 PF02591.15 KOO53567.1 - 0.39 10.9 3.6 4.7 7.5 0.2 2.9 2 0 0 2 2 2 0 C4-type zinc ribbon domain Zn-ribbon_8 PF09723.10 KOO53567.1 - 0.99 9.6 3.5 1.9 8.7 0.6 2.4 2 0 0 2 2 2 0 Zinc ribbon domain Dus PF01207.17 KOO53568.1 - 2e-47 161.8 0.0 1.5e-39 136.0 0.0 2.3 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 KOO53568.1 - 5e-05 23.1 12.4 0.0019 18.0 1.0 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KOO53568.1 - 0.00051 19.8 9.6 0.017 14.9 0.8 2.7 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOO53568.1 - 0.18 11.9 15.0 0.43 10.7 2.1 3.4 3 0 0 3 3 3 0 Zinc finger domain zf-CCCH_2 PF14608.6 KOO53568.1 - 6.5 7.4 10.0 4.1 8.0 0.3 3.2 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger TPPII_N PF12583.8 KOO53569.1 - 2.4 8.7 6.5 6 7.5 6.5 1.6 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal Kinesin PF00225.23 KOO53570.1 - 3.9e-81 272.6 0.0 5.8e-81 272.0 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain TPR_12 PF13424.6 KOO53570.1 - 3.4e-41 139.4 1.7 7.7e-17 61.4 0.1 3.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOO53570.1 - 3.2e-30 103.1 1.2 1.9e-08 33.9 0.2 4.2 3 0 0 3 3 3 3 Tetratricopeptide repeat Microtub_bd PF16796.5 KOO53570.1 - 4.6e-16 59.1 0.0 1e-15 58.0 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding TPR_7 PF13176.6 KOO53570.1 - 3.3e-13 48.6 1.3 9.1e-05 22.2 0.1 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53570.1 - 2.3e-12 46.2 3.0 0.00065 19.4 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO53570.1 - 1.4e-10 40.4 3.5 0.0019 18.2 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOO53570.1 - 4.5e-06 27.2 2.1 0.0009 19.8 0.7 4.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53570.1 - 8.6e-06 25.3 1.3 0.0025 17.5 0.1 3.4 3 0 0 3 3 3 1 TPR repeat TPR_8 PF13181.6 KOO53570.1 - 8.3e-05 22.5 0.1 8.6 6.9 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_16 PF13191.6 KOO53570.1 - 0.0088 16.4 0.1 0.0088 16.4 0.1 3.3 3 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 KOO53570.1 - 0.019 15.3 0.0 0.17 12.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain TPR_14 PF13428.6 KOO53570.1 - 0.11 13.4 13.9 0.43 11.5 0.1 5.7 3 1 2 5 5 4 0 Tetratricopeptide repeat DUF2225 PF09986.9 KOO53570.1 - 0.16 11.7 0.1 23 4.6 0.0 2.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_4 PF07721.14 KOO53570.1 - 2.8 8.8 0.0 2.8 8.8 0.0 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat End3 PF12761.7 KOO53570.1 - 8 6.6 9.7 0.67 10.1 2.6 2.4 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Muted PF14942.6 KOO53570.1 - 8.4 6.7 16.4 0.71 10.2 3.0 2.6 3 0 0 3 3 2 0 Organelle biogenesis, Muted-like protein ERM PF00769.19 KOO53570.1 - 9.7 5.9 31.3 0.29 10.9 8.7 2.8 3 0 0 3 3 3 0 Ezrin/radixin/moesin family CRC_subunit PF08624.10 KOO53572.1 - 0.018 15.5 0.0 0.19 12.1 0.0 2.0 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit ACBP PF00887.19 KOO53572.1 - 0.41 10.9 3.0 0.31 11.3 0.4 2.0 1 1 0 2 2 2 0 Acyl CoA binding protein Kelch_6 PF13964.6 KOO53573.1 - 0.059 13.7 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Kelch motif Arf PF00025.21 KOO53574.1 - 2.7e-65 219.1 1.3 3.6e-38 130.8 0.4 2.0 1 1 1 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 KOO53574.1 - 2.4e-09 37.4 0.1 5.9e-09 36.2 0.1 1.6 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOO53574.1 - 1.4e-08 34.5 0.0 1.2e-07 31.5 0.0 2.0 1 1 0 1 1 1 1 Ras family G-alpha PF00503.20 KOO53574.1 - 1.7e-08 34.1 0.7 0.0005 19.3 0.1 2.7 2 1 1 3 3 3 2 G-protein alpha subunit SRPRB PF09439.10 KOO53574.1 - 4.2e-07 29.6 0.1 5.7e-06 25.9 0.0 2.0 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOO53574.1 - 9e-05 21.9 0.0 0.00014 21.3 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOO53574.1 - 0.002 18.2 0.0 0.0028 17.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 KOO53574.1 - 0.012 15.0 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_18 PF13238.6 KOO53574.1 - 0.028 14.9 0.0 0.034 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOO53574.1 - 0.17 12.0 0.1 0.33 11.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain UQ_con PF00179.26 KOO53575.1 - 7.1e-12 45.2 0.0 1.4e-11 44.2 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme zf-RING_UBOX PF13445.6 KOO53575.1 - 3.8e-06 26.8 2.4 9.2e-06 25.6 2.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KOO53575.1 - 5.8e-06 26.5 5.5 1.2e-05 25.5 5.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOO53575.1 - 8.1e-06 25.6 6.9 1.7e-05 24.6 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOO53575.1 - 0.00015 21.5 9.5 0.00026 20.8 7.5 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO53575.1 - 0.00053 19.9 7.1 0.00097 19.1 7.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-HYPF PF07503.12 KOO53575.1 - 0.00074 19.2 3.8 0.0013 18.4 0.6 2.4 2 0 0 2 2 2 1 HypF finger zf-C3HC4_4 PF15227.6 KOO53575.1 - 0.0034 17.5 5.6 0.008 16.3 5.6 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 KOO53575.1 - 0.016 15.5 3.2 0.035 14.4 3.2 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-E2_B PF14461.6 KOO53575.1 - 0.027 14.2 0.0 0.058 13.1 0.0 1.6 1 1 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 KOO53575.1 - 0.037 14.3 0.0 0.061 13.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain Prok-RING_4 PF14447.6 KOO53575.1 - 0.064 13.1 4.9 0.13 12.1 4.9 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FYVE PF01363.21 KOO53575.1 - 0.16 12.1 6.4 0.3 11.3 6.4 1.4 1 0 0 1 1 1 0 FYVE zinc finger zf-RING_6 PF14835.6 KOO53575.1 - 0.24 11.3 2.8 0.61 10.0 2.8 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein Tmpp129 PF10272.9 KOO53575.1 - 0.53 9.5 2.0 0.84 8.9 2.0 1.3 1 0 0 1 1 1 0 Putative transmembrane protein precursor Fer2 PF00111.27 KOO53575.1 - 1.5 8.9 4.7 4.2 7.4 4.6 1.8 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Orai-1 PF07856.12 KOO53575.1 - 2.3 7.9 10.5 5.5 6.6 10.5 1.6 1 1 0 1 1 1 0 Mediator of CRAC channel activity zf-RING_4 PF14570.6 KOO53575.1 - 3.9 7.3 5.2 8.1 6.3 5.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Mob_synth_C PF06463.13 KOO53576.1 - 1.9e-37 128.0 0.0 3.1e-37 127.3 0.0 1.4 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 KOO53576.1 - 2.8e-27 96.1 0.0 5.5e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 KOO53576.1 - 2.1e-06 28.1 0.0 3.8e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 KOO53576.1 - 0.0015 18.7 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Mg_trans_NIPA PF05653.14 KOO53577.1 - 6.5e-14 51.7 4.6 9e-10 38.1 0.4 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 KOO53577.1 - 0.0031 17.7 1.0 0.0031 17.7 1.0 3.5 4 1 1 5 5 5 1 EamA-like transporter family TMEM234 PF10639.9 KOO53577.1 - 0.021 14.9 0.1 0.021 14.9 0.1 2.6 3 0 0 3 3 3 0 Putative transmembrane family 234 Homeobox_KN PF05920.11 KOO53578.1 - 5.9e-16 58.1 0.2 1e-15 57.3 0.2 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KOO53578.1 - 1.2e-07 31.4 0.2 1.6e-07 31.0 0.2 1.4 1 1 0 1 1 1 1 Homeodomain Ketoacyl-synt_2 PF13723.6 KOO53578.1 - 0.0068 16.1 0.0 0.0073 16.0 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Homez PF11569.8 KOO53578.1 - 0.017 14.6 0.1 0.025 14.0 0.1 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez FAD_binding_7 PF03441.14 KOO53579.1 - 3.7e-54 183.3 0.6 5.4e-54 182.7 0.6 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KOO53579.1 - 2.1e-31 109.1 0.0 5.2e-31 107.9 0.0 1.6 2 0 0 2 2 2 1 DNA photolyase ComX PF05952.12 KOO53579.1 - 0.22 11.5 0.3 0.7 9.9 0.0 1.9 2 0 0 2 2 2 0 Bacillus competence pheromone ComX EF-hand_6 PF13405.6 KOO53580.1 - 3e-25 86.0 1.0 2.4e-05 23.9 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO53580.1 - 3.4e-24 82.5 11.1 1.9e-06 27.0 0.3 5.0 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KOO53580.1 - 5.2e-21 74.9 8.7 2.1e-08 34.5 0.5 3.7 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KOO53580.1 - 1.8e-18 65.1 16.1 1.4e-07 30.7 0.5 5.0 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOO53580.1 - 9.6e-18 63.8 6.8 1.9e-08 34.1 0.1 4.7 2 2 3 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO53580.1 - 0.0045 17.3 0.2 40 4.6 0.0 3.7 2 2 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KOO53580.1 - 0.021 15.0 0.1 11 6.3 0.0 2.7 2 0 0 2 2 2 0 Dockerin type I domain Caleosin PF05042.13 KOO53580.1 - 0.13 12.2 0.0 60 3.5 0.0 3.3 2 2 2 4 4 4 0 Caleosin related protein Arm PF00514.23 KOO53581.1 - 8.9e-21 73.2 1.1 5.5e-08 32.6 0.0 3.3 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO53581.1 - 0.0018 18.7 2.0 0.0018 18.7 2.0 3.9 3 2 1 4 4 4 2 HEAT-like repeat Succ_CoA_lig PF13607.6 KOO53581.1 - 0.014 15.2 1.4 0.014 15.2 1.4 2.1 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain HEAT PF02985.22 KOO53581.1 - 0.042 14.1 1.0 13 6.4 0.0 3.7 3 1 1 4 4 4 0 HEAT repeat RskA PF10099.9 KOO53581.1 - 0.14 12.5 16.5 0.2 11.9 16.5 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA HEAT_2 PF13646.6 KOO53581.1 - 1.9 8.9 22.2 0.057 13.8 13.0 2.6 1 1 2 3 3 3 0 HEAT repeats CHASE3 PF05227.13 KOO53581.1 - 4.7 7.1 8.8 0.67 9.9 3.9 2.0 2 1 1 3 3 3 0 CHASE3 domain PEX11 PF05648.14 KOO53582.1 - 0.0018 17.8 0.5 0.0052 16.3 0.2 1.8 2 0 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) MMS22L_C PF14911.6 KOO53582.1 - 0.14 11.3 0.1 0.19 10.8 0.1 1.2 1 0 0 1 1 1 0 S-phase genomic integrity recombination mediator, C-terminal EAF PF09816.9 KOO53583.1 - 0.0027 18.1 0.0 0.0045 17.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor FlgM PF04316.13 KOO53583.1 - 0.13 12.6 0.6 0.13 12.6 0.6 2.0 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM FIT1_2 PF17357.2 KOO53583.1 - 0.29 11.2 1.3 0.66 10.1 1.2 1.6 1 1 1 2 2 2 0 Facilitor Of iron transport 1 and 2 Ytp1 PF10355.9 KOO53584.1 - 0.00067 18.9 0.2 0.0014 17.9 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (Ytp1) Methyltransf_8 PF05148.15 KOO53586.1 - 2.3e-73 246.7 0.0 2.6e-73 246.5 0.0 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 KOO53586.1 - 6.1e-05 23.6 0.2 0.00076 20.1 0.2 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO53586.1 - 0.0011 18.8 0.1 0.026 14.3 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOO53586.1 - 0.0015 19.2 0.2 0.57 10.9 0.0 2.5 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 KOO53586.1 - 0.0016 18.0 0.0 0.0077 15.8 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase small domain PUB PF09409.10 KOO53586.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 PUB domain 2OG-FeII_Oxy_3 PF13640.6 KOO53587.1 - 0.016 16.1 0.0 0.022 15.6 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily LSM PF01423.22 KOO53588.1 - 9.6e-17 60.5 0.1 1.3e-16 60.1 0.1 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 KOO53588.1 - 0.013 15.2 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Hfq protein HEAT_2 PF13646.6 KOO53589.1 - 9.6e-14 51.5 13.3 5.8e-08 33.0 2.4 3.1 2 1 0 3 3 3 2 HEAT repeats HEAT PF02985.22 KOO53589.1 - 1.4e-09 37.3 6.2 0.046 14.0 0.1 5.9 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 KOO53589.1 - 6.2e-08 33.0 9.6 0.029 14.9 0.1 5.5 6 0 0 6 6 6 2 HEAT-like repeat Rap1a PF18602.1 KOO53589.1 - 1.7e-05 25.0 8.2 1 9.7 0.1 5.1 3 1 3 6 6 6 3 Rap1a immunity proteins Cnd1 PF12717.7 KOO53589.1 - 0.01 15.9 4.9 0.029 14.4 0.2 2.9 1 1 2 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 KOO53589.1 - 0.013 15.5 1.0 12 6.1 0.0 3.5 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat ERAP1_C PF11838.8 KOO53589.1 - 0.013 15.1 0.6 0.018 14.6 0.6 1.3 1 0 0 1 1 1 0 ERAP1-like C-terminal domain THDPS_N_2 PF14805.6 KOO53589.1 - 0.05 13.8 4.1 19 5.5 0.1 4.1 2 1 2 4 4 4 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Peptidase_S9 PF00326.21 KOO53589.1 - 0.072 12.6 2.5 4.5 6.7 0.1 3.1 1 1 1 3 3 3 0 Prolyl oligopeptidase family DnaG_DnaB_bind PF08278.11 KOO53589.1 - 0.28 11.8 4.9 0.32 11.6 3.1 2.0 1 1 0 1 1 1 0 DNA primase DnaG DnaB-binding Ntox1 PF15500.6 KOO53589.1 - 0.73 10.2 5.8 4.6 7.7 0.2 3.7 1 1 4 5 5 5 0 Putative RNase-like toxin, toxin_1 GGDEF_2 PF17853.1 KOO53589.1 - 1.9 8.8 8.0 6.7 7.0 1.1 3.1 1 1 2 3 3 3 0 GGDEF-like domain Cohesin_HEAT PF12765.7 KOO53589.1 - 2 8.8 5.2 13 6.2 0.2 3.4 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion ADPrib_exo_Tox PF03496.14 KOO53590.1 - 1.5e-09 37.5 0.0 5.6e-09 35.6 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosyltransferase exoenzyme ART PF01129.18 KOO53590.1 - 4.8e-08 32.6 0.0 9.4e-08 31.6 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Apolipoprotein PF01442.18 KOO53590.1 - 0.027 14.3 1.7 0.038 13.9 0.0 2.0 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain CK2S PF15011.6 KOO53590.1 - 0.11 12.3 0.3 2.6 7.9 0.1 2.3 2 0 0 2 2 2 0 Casein Kinase 2 substrate DUF3289 PF11692.8 KOO53590.1 - 0.17 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3289) Phage_integrase PF00589.22 KOO53591.1 - 0.00094 19.0 0.0 0.0014 18.5 0.0 1.2 1 0 0 1 1 1 1 Phage integrase family Peptidase_M20 PF01546.28 KOO53592.1 - 1.2e-07 31.6 0.0 7.1e-07 29.1 0.0 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 KOO53592.1 - 0.002 17.8 0.0 0.0052 16.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 U-box PF04564.15 KOO53593.1 - 2e-10 40.7 0.0 8.1e-10 38.7 0.0 1.8 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 KOO53593.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KOO53593.1 - 0.016 15.3 0.1 0.026 14.7 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Actin PF00022.19 KOO53594.1 - 2e-148 494.4 0.0 6.6e-148 492.7 0.0 1.7 1 1 0 1 1 1 1 Actin RVT_2 PF07727.14 KOO53595.1 - 0.019 14.6 0.0 0.045 13.4 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) TALPID3 PF15324.6 KOO53597.1 - 3.4 5.2 5.5 4 5.0 5.5 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Trp_Tyr_perm PF03222.13 KOO53599.1 - 1.2e-20 74.0 1.7 8.5e-10 38.2 0.4 2.0 2 0 0 2 2 2 2 Tryptophan/tyrosine permease family DUF4914 PF16260.5 KOO53599.1 - 0.08 11.0 0.0 0.11 10.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4914) DUF1724 PF08350.10 KOO53599.1 - 0.1 12.8 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1724) Galactosyl_T PF01762.21 KOO53600.1 - 0.0017 18.2 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase DUF4407 PF14362.6 KOO53604.1 - 0.24 10.7 7.9 0.31 10.4 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pro_isomerase PF00160.21 KOO53605.1 - 4.3e-35 121.3 0.0 8.3e-35 120.4 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD IQ PF00612.27 KOO53605.1 - 4.1e-05 23.0 1.3 0.0066 16.2 0.1 2.4 2 0 0 2 2 2 2 IQ calmodulin-binding motif PIF1 PF05970.14 KOO53606.1 - 8.8e-12 44.9 0.0 3.8e-10 39.5 0.0 2.1 2 0 0 2 2 2 2 PIF1-like helicase SH3_13 PF18335.1 KOO53606.1 - 0.00036 20.3 0.0 0.00061 19.6 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent RecD-like DNA helicase SH3 domain Herpes_Helicase PF02689.14 KOO53606.1 - 0.00077 17.5 0.0 0.0011 17.0 0.0 1.1 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.6 KOO53606.1 - 0.032 14.0 0.1 0.11 12.3 0.1 1.9 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF4926 PF16277.5 KOO53606.1 - 0.16 11.4 0.1 0.37 10.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4926) DUF445 PF04286.12 KOO53607.1 - 2.2e-11 44.2 0.4 5.6e-09 36.3 0.0 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF445) UreF PF01730.16 KOO53607.1 - 0.032 14.8 0.1 0.071 13.7 0.1 1.5 1 0 0 1 1 1 0 UreF Romo1 PF10247.9 KOO53607.1 - 0.17 12.3 2.8 1.5 9.2 0.1 2.5 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Cofac_haem_bdg PF04187.13 KOO53608.1 - 8.1e-13 48.9 0.3 6.4e-11 42.7 0.3 2.3 1 1 1 2 2 2 2 Haem-binding uptake, Tiki superfamily, ChaN FAST_1 PF06743.15 KOO53608.1 - 0.025 14.5 0.0 19 5.3 0.0 3.6 3 1 1 4 4 4 0 FAST kinase-like protein, subdomain 1 EcKinase PF02958.20 KOO53609.1 - 2.5e-08 33.6 0.5 7.4e-07 28.8 0.0 2.4 2 0 0 2 2 2 1 Ecdysteroid kinase APH PF01636.23 KOO53609.1 - 1.3e-05 25.2 0.8 5.4e-05 23.2 0.1 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 KOO53609.1 - 0.00052 19.0 0.1 0.0013 17.7 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) Response_reg PF00072.24 KOO53609.1 - 0.0056 16.8 0.0 0.015 15.4 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Choline_kinase PF01633.20 KOO53609.1 - 0.0075 15.9 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase TPR_12 PF13424.6 KOO53609.1 - 0.0092 16.2 2.3 1.2 9.5 0.5 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat LcrV PF04792.12 KOO53609.1 - 0.17 11.2 1.0 0.57 9.4 0.5 1.9 1 1 1 2 2 2 0 V antigen (LcrV) protein DUF5033 PF16436.5 KOO53609.1 - 9 6.2 8.0 29 4.5 0.6 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5033) RNA_GG_bind PF10258.9 KOO53610.1 - 2.1e-19 69.3 0.0 3.8e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 PHAX RNA-binding domain zf-CCHC_2 PF13696.6 KOO53610.1 - 4.8e-13 48.6 27.5 4.7e-05 23.1 3.2 4.2 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_3 PF13917.6 KOO53610.1 - 8.9e-05 22.4 11.0 0.025 14.6 0.4 2.7 2 1 0 2 2 2 2 Zinc knuckle zf-CCHC PF00098.23 KOO53610.1 - 0.00046 20.1 4.9 0.23 11.6 0.5 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 KOO53610.1 - 0.0029 17.3 11.0 0.12 12.1 1.3 3.4 3 0 0 3 3 3 2 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 KOO53610.1 - 0.074 12.8 4.7 4.3 7.1 0.4 2.6 2 0 0 2 2 2 0 Zinc knuckle CLIP1_ZNF PF16641.5 KOO53610.1 - 0.26 11.2 2.4 12 6.0 0.1 2.6 2 0 0 2 2 2 0 CLIP1 zinc knuckle DUF2197 PF09963.9 KOO53610.1 - 0.44 10.9 11.4 5.2 7.4 0.0 4.3 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2197) PHD PF00628.29 KOO53610.1 - 5.2 7.0 17.8 8.2 6.4 4.1 3.2 1 1 3 4 4 4 0 PHD-finger eIF3g PF12353.8 KOO53610.1 - 7.2 7.0 16.2 4.7 7.6 0.0 3.4 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G LRR_6 PF13516.6 KOO53611.1 - 3.2e-19 67.3 4.2 4.2e-05 23.3 0.1 4.7 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 KOO53611.1 - 0.0045 17.4 0.3 0.44 11.0 0.2 3.0 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) GW PF13457.6 KOO53611.1 - 0.14 12.8 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 GW (Gly-Tryp) dipeptide domain NLRC4_HD2 PF17776.1 KOO53611.1 - 0.17 12.4 0.0 0.34 11.5 0.0 1.5 1 0 0 1 1 1 0 NLRC4 helical domain HD2 CS PF04969.16 KOO53612.1 - 2.8e-11 44.2 0.0 4.5e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 CS domain Qn_am_d_aIII PF09099.10 KOO53612.1 - 0.012 16.0 0.5 6.6 7.2 0.0 2.5 1 1 1 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III ELYS-bb PF16687.5 KOO53612.1 - 0.11 11.1 0.2 0.13 10.8 0.2 1.1 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin CSN5_C PF18323.1 KOO53613.1 - 0.028 15.3 0.2 0.054 14.4 0.2 1.4 1 0 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain DUF3138 PF11336.8 KOO53613.1 - 0.69 8.5 2.9 0.98 8.0 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Laminin_G_3 PF13385.6 KOO53614.1 - 6.5e-07 29.6 0.2 1.3e-06 28.7 0.2 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily ART PF01129.18 KOO53615.1 - 6.2e-17 61.6 0.0 8.5e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KOO53615.1 - 3.5e-05 23.2 0.0 6.4e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme CCDC-167 PF15188.6 KOO53615.1 - 0.19 12.1 0.2 32 4.9 0.0 2.9 2 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 Paf1 PF03985.13 KOO53616.1 - 2.7e-52 178.2 0.0 2.7e-52 178.2 0.0 1.9 2 0 0 2 2 2 1 Paf1 Sec34 PF04136.15 KOO53616.1 - 0.012 15.5 0.2 0.019 14.9 0.2 1.3 1 0 0 1 1 1 0 Sec34-like family EF-hand_7 PF13499.6 KOO53618.1 - 2e-13 50.6 4.7 1.1e-07 32.2 0.7 2.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOO53618.1 - 1.1e-11 43.7 0.5 0.00018 21.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain WW PF00397.26 KOO53618.1 - 5.5e-10 39.2 0.1 1.7e-09 37.6 0.1 1.9 1 0 0 1 1 1 1 WW domain EF-hand_1 PF00036.32 KOO53618.1 - 9.4e-10 37.4 0.3 0.001 18.5 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO53618.1 - 1e-05 25.3 0.3 3.3e-05 23.7 0.1 2.0 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO53618.1 - 0.012 15.1 0.4 2.1 8.0 0.0 2.6 2 0 0 2 2 2 0 EF hand Nucleo_P87 PF07267.11 KOO53618.1 - 0.015 14.1 0.5 0.019 13.8 0.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Armet PF10208.9 KOO53618.1 - 0.13 12.2 0.1 0.22 11.4 0.1 1.3 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding p25-alpha PF05517.12 KOO53618.1 - 0.17 12.0 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 p25-alpha Ketoacyl-synt_C PF02801.22 KOO53619.1 - 2.3e-17 63.1 1.8 4.6e-17 62.1 1.8 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 KOO53619.1 - 7.9e-16 58.1 0.1 1.1e-15 57.7 0.1 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 KOO53619.1 - 0.0002 21.8 0.0 0.00033 21.1 0.0 1.3 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Exo_endo_phos PF03372.23 KOO53621.1 - 8.2e-13 48.4 0.0 1.7e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family 4HB_MCP_1 PF12729.7 KOO53621.1 - 0.072 12.6 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Pneumo_ncap PF03246.13 KOO53621.1 - 0.11 11.2 0.0 0.19 10.4 0.0 1.3 1 0 0 1 1 1 0 Pneumovirus nucleocapsid protein SPATA1_C PF15743.5 KOO53625.1 - 0.76 9.8 3.8 1.4 8.9 3.8 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus Macoilin PF09726.9 KOO53625.1 - 0.8 8.2 7.2 1 7.9 7.2 1.2 1 0 0 1 1 1 0 Macoilin family EF-hand_1 PF00036.32 KOO53626.1 - 3e-11 42.0 0.3 5.8e-05 22.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO53626.1 - 3.1e-09 36.0 0.5 0.00031 20.4 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO53626.1 - 3.4e-08 33.8 0.2 8.4e-08 32.6 0.3 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KOO53626.1 - 0.00026 20.3 0.4 0.1 12.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO53626.1 - 0.011 15.6 0.9 0.18 11.7 0.2 2.1 1 1 1 2 2 2 0 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOO53626.1 - 0.013 15.8 0.1 0.018 15.3 0.1 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Glyco_trans_1_4 PF13692.6 KOO53627.1 - 2.1e-12 47.6 0.1 5.8e-12 46.2 0.1 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Sulfotransfer_3 PF13469.6 KOO53627.1 - 0.0022 18.4 0.1 0.0075 16.7 0.1 1.9 1 1 0 1 1 1 1 Sulfotransferase family Glycos_transf_1 PF00534.20 KOO53627.1 - 0.0031 17.1 0.0 0.0053 16.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Phage-MuB_C PF09077.11 KOO53629.1 - 0.22 11.4 1.3 0.32 10.9 0.1 1.9 2 0 0 2 2 2 0 Mu B transposition protein, C terminal bHLH-MYC_N PF14215.6 KOO53630.1 - 0.061 13.6 0.0 0.19 12.0 0.0 1.7 2 0 0 2 2 2 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal cNMP_binding PF00027.29 KOO53631.1 - 7.1e-44 147.8 0.0 8.4e-22 77.0 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PP2C PF00481.21 KOO53631.1 - 2e-36 125.9 0.0 3.5e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Pkinase PF00069.25 KOO53631.1 - 3.2e-22 79.2 0.0 1.1e-21 77.4 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53631.1 - 1.1e-05 24.9 0.0 1.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PP2C_2 PF13672.6 KOO53631.1 - 6.3e-05 22.7 0.0 0.00033 20.4 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C LIF_OSM PF01291.17 KOO53633.1 - 0.017 15.3 1.1 0.028 14.6 0.2 1.8 2 0 0 2 2 2 0 LIF / OSM family Alpha-amyl_C PF09071.10 KOO53633.1 - 0.041 13.7 0.5 0.78 9.6 0.3 2.6 2 0 0 2 2 2 0 Alpha-amylase, C terminal PNGaseA PF12222.8 KOO53633.1 - 0.13 11.1 3.3 0.2 10.5 3.3 1.3 1 0 0 1 1 1 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A HrpB7 PF09486.10 KOO53633.1 - 1.2 9.5 8.8 0.3 11.4 1.5 2.9 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF1664 PF07889.12 KOO53633.1 - 1.9 8.6 12.2 0.96 9.5 1.9 3.2 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) TMF_TATA_bd PF12325.8 KOO53633.1 - 3.2 8.0 8.8 2.5 8.4 0.4 4.1 4 1 1 5 5 5 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.10 KOO53633.1 - 7.2 6.8 8.8 20 5.4 1.2 3.2 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Glyco_transf_8 PF01501.20 KOO53634.1 - 0.035 13.7 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 8 Blt1 PF12754.7 KOO53636.1 - 0.31 11.4 3.1 0.2 11.9 1.8 1.4 1 1 0 1 1 1 0 Blt1 N-terminal domain RabGAP-TBC PF00566.18 KOO53640.1 - 9.8e-25 87.5 0.0 1.3e-24 87.1 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LRR_12 PF18837.1 KOO53640.1 - 0.18 11.5 0.0 0.38 10.4 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat Ion_trans PF00520.31 KOO53642.1 - 4.1e-09 36.0 15.7 1e-08 34.7 15.5 1.6 1 1 0 1 1 1 1 Ion transport protein LSDAT_euk PF18139.1 KOO53642.1 - 3.4e-08 33.2 0.0 5.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 SLOG in TRPM PKD_channel PF08016.12 KOO53642.1 - 4.6e-08 32.2 8.2 6.6e-08 31.6 8.2 1.2 1 0 0 1 1 1 1 Polycystin cation channel LSDAT_prok PF18171.1 KOO53642.1 - 2.7e-07 30.0 0.0 3.2e-06 26.5 0.0 2.5 1 1 0 1 1 1 1 SLOG in TRPM, prokaryote PWI PF01480.17 KOO53643.1 - 2.1e-10 40.8 0.0 3e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 PWI domain DUF3046 PF11248.8 KOO53643.1 - 0.011 16.1 0.1 0.032 14.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3046) DSPc PF00782.20 KOO53644.1 - 3.4e-19 69.0 0.0 5.3e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF563 PF04577.14 KOO53644.1 - 6.6e-09 36.2 0.0 1.1e-08 35.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Y_phosphatase PF00102.27 KOO53644.1 - 0.13 11.9 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase gag_pre-integrs PF13976.6 KOO53645.1 - 1.8e-07 30.9 0.0 2.9e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 KOO53645.1 - 0.00033 20.9 0.1 0.0015 18.7 0.0 2.0 1 1 1 2 2 2 1 Integrase core domain TGFb_propeptide PF00688.18 KOO53647.1 - 0.06 13.1 5.0 0.29 10.9 0.1 3.2 4 0 0 4 4 4 0 TGF-beta propeptide Disaggr_repeat PF06848.11 KOO53647.1 - 0.099 12.3 0.0 7 6.3 0.0 2.4 2 0 0 2 2 2 0 Disaggregatase related repeat HTH_Tnp_ISL3 PF13542.6 KOO53648.1 - 0.11 11.9 2.5 35 3.9 0.5 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 DUF5055 PF16478.5 KOO53651.1 - 0.015 15.5 0.0 0.017 15.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5055) Thioredoxin_8 PF13905.6 KOO53652.1 - 2.8e-21 75.6 0.0 6.4e-21 74.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 KOO53652.1 - 9.7e-06 25.5 0.0 0.0013 18.7 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 KOO53652.1 - 0.00016 22.1 0.0 0.00038 20.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 KOO53652.1 - 0.049 13.6 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family EF-hand_1 PF00036.32 KOO53653.1 - 3.6e-25 85.6 0.9 1.2e-06 27.6 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KOO53653.1 - 4.7e-23 79.1 1.6 0.00024 20.8 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KOO53653.1 - 6.2e-20 71.4 0.0 4.9e-09 36.5 0.0 3.5 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO53653.1 - 1.2e-19 68.8 6.2 0.00059 19.2 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOO53653.1 - 1.4e-15 56.8 2.1 0.0046 16.8 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_10 PF14788.6 KOO53653.1 - 0.00011 22.0 1.1 3.5 7.5 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_4 PF12763.7 KOO53653.1 - 0.063 13.2 0.1 31 4.6 0.0 3.3 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOO53653.1 - 0.12 12.7 0.8 16 5.8 0.1 3.3 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region ACC_epsilon PF13822.6 KOO53653.1 - 4.6 8.0 6.6 0.78 10.5 0.4 2.4 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit EF-hand_6 PF13405.6 KOO53654.1 - 1.4e-36 121.2 15.4 8.1e-06 25.4 0.0 8.4 5 3 3 8 8 8 8 EF-hand domain EF-hand_1 PF00036.32 KOO53654.1 - 1.1e-35 118.5 14.3 3.8e-05 22.9 0.0 8.3 7 1 1 8 8 8 7 EF hand EF-hand_7 PF13499.6 KOO53654.1 - 3.9e-32 110.5 2.5 3.8e-06 27.2 0.3 5.8 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 KOO53654.1 - 3.5e-25 86.3 19.8 2.2e-05 23.7 0.0 8.2 8 0 0 8 8 8 7 EF hand EF-hand_8 PF13833.6 KOO53654.1 - 1.1e-23 82.8 11.7 3.3e-08 33.2 0.0 6.2 4 1 1 6 6 6 6 EF-hand domain pair EF-hand_9 PF14658.6 KOO53654.1 - 3e-07 30.7 0.3 0.054 13.8 0.0 4.1 3 1 1 4 4 4 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOO53654.1 - 0.0003 21.1 0.0 5.9 7.2 0.0 3.8 4 0 0 4 4 3 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 KOO53654.1 - 0.0035 17.3 0.2 8.7 6.2 0.0 4.7 3 2 1 5 5 5 1 Caleosin related protein EF-hand_4 PF12763.7 KOO53654.1 - 0.01 15.8 3.3 12 5.9 0.1 4.8 2 2 3 5 5 5 0 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 KOO53654.1 - 0.034 14.5 0.2 72 3.8 0.1 3.8 2 1 1 3 3 3 0 EF-hand domain SAP PF02037.27 KOO53654.1 - 0.038 13.8 1.5 8.9 6.2 0.0 3.2 3 0 0 3 3 3 0 SAP domain SurA_N_2 PF13623.6 KOO53654.1 - 0.043 13.7 0.0 0.98 9.3 0.0 3.0 3 1 1 4 4 4 0 SurA N-terminal domain EF-hand_10 PF14788.6 KOO53654.1 - 0.073 12.9 1.9 15 5.5 0.0 4.3 5 1 1 6 6 6 0 EF hand LEM PF03020.15 KOO53654.1 - 0.13 11.9 3.6 17 5.1 0.1 3.8 4 0 0 4 4 4 0 LEM domain Abhydrolase_4 PF08386.10 KOO53655.1 - 0.0068 16.5 0.0 0.0073 16.4 0.0 1.2 1 0 0 1 1 1 1 TAP-like protein LpxD PF04613.14 KOO53655.1 - 0.0082 15.9 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Hydrolase_4 PF12146.8 KOO53655.1 - 0.054 12.8 0.0 0.07 12.4 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Glyco_hydro_47 PF01532.20 KOO53656.1 - 4e-36 124.9 0.1 5.4e-36 124.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Mito_carr PF00153.27 KOO53657.1 - 2.1e-47 159.0 8.5 6.4e-17 61.3 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 KOO53659.1 - 3.1e-39 132.2 17.4 5e-06 27.2 0.2 8.7 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO53659.1 - 4.4e-11 42.9 2.4 0.027 14.8 0.0 5.4 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Utp13 PF08625.11 KOO53659.1 - 0.00026 20.9 0.3 0.00046 20.1 0.3 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nup160 PF11715.8 KOO53659.1 - 0.00054 18.7 7.0 0.44 9.1 1.6 3.7 2 2 1 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOO53659.1 - 0.028 13.4 1.1 7.7 5.4 0.0 3.2 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KOO53659.1 - 0.28 10.5 0.0 4.7 6.4 0.0 2.5 2 1 2 4 4 4 0 WD40-like domain DUF3593 PF12159.8 KOO53660.1 - 2.2e-25 88.5 0.2 3.9e-25 87.7 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3593) DUF2499 PF10693.9 KOO53660.1 - 1.7e-19 69.9 0.3 5e-19 68.4 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2499) TPR_2 PF07719.17 KOO53661.1 - 1.3e-14 53.0 12.2 0.00025 20.9 0.0 6.8 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53661.1 - 1.3e-11 43.8 4.2 0.00053 19.7 0.0 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53661.1 - 2.6e-10 39.8 0.6 0.66 9.7 0.0 4.7 4 1 1 5 5 5 4 TPR repeat TPR_16 PF13432.6 KOO53661.1 - 2.6e-09 37.6 21.9 6.4e-05 23.5 0.2 5.2 4 1 2 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53661.1 - 9.7e-07 28.5 3.1 0.76 10.1 0.0 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53661.1 - 9.8e-05 22.9 23.9 0.027 15.3 0.7 5.6 3 2 3 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53661.1 - 0.00033 20.9 13.9 0.12 12.6 0.7 4.6 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOO53661.1 - 0.0004 20.8 12.3 0.018 15.5 0.1 4.7 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOO53661.1 - 0.0017 18.6 0.8 2.5 8.7 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat Coatomer_E PF04733.14 KOO53661.1 - 0.0056 16.1 0.3 0.83 9.0 0.0 3.0 2 1 1 3 3 3 1 Coatomer epsilon subunit Retrotran_gag_3 PF14244.6 KOO53661.1 - 0.034 14.0 0.1 17 5.3 0.0 2.9 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type DUF2530 PF10745.9 KOO53661.1 - 0.055 13.7 0.0 20 5.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) TPR_9 PF13371.6 KOO53661.1 - 0.065 13.4 11.8 0.066 13.4 1.3 4.1 2 1 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOO53661.1 - 0.22 12.3 3.0 65 4.5 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOO53661.1 - 1 9.6 13.3 0.17 12.1 1.3 3.6 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 ATG16 PF08614.11 KOO53662.1 - 0.033 14.4 0.1 0.033 14.4 0.1 1.0 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) EF-hand_6 PF13405.6 KOO53663.1 - 1.2e-06 28.0 0.5 0.00018 21.2 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOO53663.1 - 2.9e-06 27.6 0.0 6e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOO53663.1 - 4.5e-06 25.8 0.2 0.0045 16.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KOO53663.1 - 0.0006 19.6 0.5 0.29 11.0 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO53663.1 - 0.0084 15.6 4.4 0.037 13.5 0.0 2.8 3 0 0 3 3 3 1 EF hand TDA11 PF17084.5 KOO53663.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Topoisomerase I damage affected protein 11 CCDC14 PF15254.6 KOO53663.1 - 2.7 6.5 4.4 3.9 6.0 4.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 14-3-3 PF00244.20 KOO53664.1 - 8.8e-95 316.4 1.7 9.9e-95 316.2 1.7 1.0 1 0 0 1 1 1 1 14-3-3 protein NIBRIN_BRCT_II PF16508.5 KOO53664.1 - 0.21 12.0 1.0 4.1 7.8 0.1 2.7 1 1 2 3 3 3 0 Second BRCT domain on Nijmegen syndrome breakage protein TPR_8 PF13181.6 KOO53664.1 - 2.2 8.7 5.8 2.5 8.5 0.6 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PE PF00934.20 KOO53666.1 - 9.4 6.6 11.6 0.13 12.6 2.9 2.4 3 1 0 3 3 3 0 PE family WD40 PF00400.32 KOO53667.1 - 4.3e-43 144.5 13.8 2.3e-09 37.7 0.2 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO53667.1 - 8.8e-05 22.7 1.8 2.5 8.4 0.2 4.7 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KOO53667.1 - 0.0014 17.5 0.0 0.62 8.8 0.0 3.0 2 1 0 3 3 3 2 Nup133 N terminal like WD40_like PF17005.5 KOO53667.1 - 0.048 13.0 0.0 8.4 5.6 0.0 2.7 2 1 1 3 3 3 0 WD40-like domain Nup160 PF11715.8 KOO53667.1 - 0.13 10.9 2.8 31 3.0 0.0 3.9 2 2 1 4 4 4 0 Nucleoporin Nup120/160 CDC37_C PF08564.10 KOO53668.1 - 0.036 14.2 0.1 0.056 13.6 0.1 1.4 1 0 0 1 1 1 0 Cdc37 C terminal domain Peptidase_C1 PF00112.23 KOO53669.1 - 1.5e-54 185.3 9.6 2e-54 185.0 9.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KOO53669.1 - 1.8e-09 37.9 0.0 2.9e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KOO53669.1 - 1.5e-05 24.0 1.2 0.049 12.4 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Nop10p PF04135.12 KOO53670.1 - 0.84 9.7 2.8 2.3 8.3 2.8 1.7 1 0 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family DnaJ PF00226.31 KOO53671.1 - 3.1e-09 36.8 0.0 8.1e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain COMM_domain PF07258.14 KOO53671.1 - 6.7e-09 35.7 0.0 1.5e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 COMM domain Zip PF02535.22 KOO53672.1 - 3.1e-15 56.3 15.4 9.1e-13 48.1 8.8 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter DAO PF01266.24 KOO53673.1 - 1.1e-24 87.7 1.3 1.3e-24 87.5 1.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF4054 PF13262.6 KOO53673.1 - 0.057 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4054) TPR_8 PF13181.6 KOO53674.1 - 0.00042 20.3 1.8 0.55 10.6 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53674.1 - 0.00044 19.9 0.1 0.00044 19.9 0.1 2.7 2 1 1 3 3 3 1 TPR repeat TPR_2 PF07719.17 KOO53674.1 - 0.0014 18.6 9.9 0.029 14.5 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53674.1 - 0.097 12.5 2.6 0.9 9.5 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Fmp27_GFWDK PF10347.9 KOO53674.1 - 0.2 11.8 0.0 0.35 11.0 0.0 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain TPR_19 PF14559.6 KOO53674.1 - 0.25 11.9 14.5 2.5 8.7 7.7 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOO53674.1 - 0.9 9.7 6.1 5.7 7.2 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53674.1 - 2.2 9.3 25.3 0.86 10.6 2.2 5.2 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOO53674.1 - 3.5 8.3 20.8 0.12 13.0 13.0 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 KOO53674.1 - 5.6 7.4 10.5 0.57 10.6 5.4 2.1 2 1 1 3 3 3 0 Tetratricopeptide repeat Arm PF00514.23 KOO53675.1 - 1e-08 34.9 14.6 0.0041 17.1 0.1 5.9 6 2 1 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOO53675.1 - 0.83 10.2 10.6 13 6.5 0.2 4.8 4 1 0 4 4 4 0 HEAT-like repeat Arm PF00514.23 KOO53676.1 - 3.1e-24 84.2 14.3 4e-06 26.7 0.1 5.5 5 1 0 5 5 5 5 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 KOO53676.1 - 0.0036 16.8 0.0 0.032 13.7 0.0 2.3 2 1 0 2 2 2 1 Armadillo-like HEAT_2 PF13646.6 KOO53676.1 - 0.043 14.2 1.0 0.043 14.2 1.0 3.8 1 1 2 3 3 3 0 HEAT repeats EST1_DNA_bind PF10373.9 KOO53677.1 - 0.075 12.5 0.1 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain TPR_11 PF13414.6 KOO53678.1 - 4e-13 48.8 0.0 1.9e-06 27.4 0.1 3.7 2 1 1 3 3 3 3 TPR repeat TPR_1 PF00515.28 KOO53678.1 - 1.7e-08 33.9 0.4 0.11 12.3 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOO53678.1 - 6.6e-07 29.0 3.6 0.038 14.1 0.0 4.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOO53678.1 - 9.4e-07 28.6 0.4 0.43 10.9 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOO53678.1 - 1.1e-06 28.6 0.0 0.25 11.8 0.0 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOO53678.1 - 2.2e-06 28.0 9.5 0.044 14.6 0.1 5.0 3 2 2 5 5 5 2 Tetratricopeptide repeat ShK PF01549.24 KOO53678.1 - 1.3e-05 25.6 10.3 1.3e-05 25.6 10.3 2.0 2 0 0 2 2 2 1 ShK domain-like TPR_16 PF13432.6 KOO53678.1 - 0.00024 21.7 12.0 0.32 11.7 0.2 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53678.1 - 0.0029 17.9 4.4 0.13 12.6 0.1 4.0 1 1 2 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 KOO53678.1 - 0.016 15.5 0.8 4.6 7.6 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOO53678.1 - 0.098 13.2 5.0 1.6 9.3 0.3 3.6 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOO53678.1 - 0.19 11.6 2.2 2.3 8.2 0.1 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat PH_12 PF16457.5 KOO53680.1 - 0.0012 19.4 0.0 0.071 13.6 0.0 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain Cas_Cas1 PF01867.16 KOO53680.1 - 0.033 13.3 3.1 0.076 12.2 3.1 1.5 1 0 0 1 1 1 0 CRISPR associated protein Cas1 TFB6 PF17110.5 KOO53680.1 - 4.5 7.0 5.4 0.81 9.4 0.6 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Agouti PF05039.12 KOO53680.1 - 5.4 7.8 10.2 18 6.1 0.7 2.8 2 0 0 2 2 2 0 Agouti protein Glyco_transf_10 PF00852.19 KOO53681.1 - 1.3e-16 60.8 0.0 3.9e-16 59.3 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Pkinase PF00069.25 KOO53684.1 - 2e-45 155.2 0.0 2.6e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53684.1 - 4.6e-38 131.0 0.0 8.2e-38 130.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOO53684.1 - 5.5e-05 22.1 0.0 9.7e-05 21.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOO53684.1 - 0.0032 16.8 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOO53684.1 - 0.019 14.9 0.1 0.32 10.9 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 KOO53684.1 - 0.034 13.5 0.1 0.064 12.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ETAA1 PF15350.6 KOO53684.1 - 0.67 8.2 3.5 3.7 5.7 0.4 2.1 1 1 1 2 2 2 0 Ewing's tumour-associated antigen 1 homologue WD40 PF00400.32 KOO53685.1 - 3.3e-12 46.7 2.7 0.012 16.4 0.1 7.4 8 0 0 8 8 8 3 WD domain, G-beta repeat Exotox-A_bind PF09101.10 KOO53685.1 - 0.16 11.3 0.0 14 4.9 0.0 2.4 2 0 0 2 2 2 0 Exotoxin A binding zf-RING_2 PF13639.6 KOO53686.1 - 2.3e-06 27.8 8.2 2.3e-06 27.8 8.2 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 KOO53686.1 - 4.8e-06 26.5 2.4 4.8e-06 26.5 2.4 2.2 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOO53686.1 - 6.5e-06 25.9 6.2 6.5e-06 25.9 6.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOO53686.1 - 2.7e-05 24.0 6.2 2.7e-05 24.0 6.2 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOO53686.1 - 5.7e-05 22.9 10.8 6.7e-05 22.7 6.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS91 PF14319.6 KOO53686.1 - 0.003 17.6 5.2 0.003 17.6 5.2 1.8 2 0 0 2 2 2 1 Transposase zinc-binding domain zf-ANAPC11 PF12861.7 KOO53686.1 - 0.14 12.2 4.4 0.48 10.5 4.4 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger CK_II_beta PF01214.18 KOO53687.1 - 1.4e-74 249.8 0.1 2.2e-74 249.2 0.1 1.3 1 0 0 1 1 1 1 Casein kinase II regulatory subunit tRNA_edit PF04073.15 KOO53687.1 - 2.2e-05 24.5 0.0 4.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain DTW PF03942.15 KOO53689.1 - 8e-18 64.9 0.0 1.1e-17 64.4 0.0 1.1 1 0 0 1 1 1 1 DTW domain Comm PF15957.5 KOO53689.1 - 0.21 11.9 0.0 0.35 11.2 0.0 1.3 1 0 0 1 1 1 0 Commissureless WD40 PF00400.32 KOO53690.1 - 1.7e-10 41.3 0.5 1.5e-07 31.9 0.1 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Pkinase PF00069.25 KOO53690.1 - 0.16 11.3 0.0 20 4.4 0.0 2.9 2 1 0 2 2 2 0 Protein kinase domain Trigger_C PF05698.14 KOO53690.1 - 3.3 7.7 6.0 2.6 8.0 3.6 2.0 2 0 0 2 2 2 0 Bacterial trigger factor protein (TF) C-terminus RVT_2 PF07727.14 KOO53691.1 - 2.3e-34 119.1 0.0 3.6e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tricorn_C1 PF14684.6 KOO53692.1 - 9.8e-15 54.4 0.0 1.7e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Tricorn protease C1 domain Peptidase_S41 PF03572.18 KOO53692.1 - 7.1e-13 48.5 0.0 1.2e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 Tricorn_PDZ PF14685.6 KOO53692.1 - 0.00023 21.1 0.0 0.00056 19.8 0.0 1.6 1 0 0 1 1 1 1 Tricorn protease PDZ domain PD40 PF07676.12 KOO53692.1 - 0.064 13.2 0.5 3.4 7.7 0.1 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat PAN_4 PF14295.6 KOO53693.1 - 0.00017 21.4 9.1 0.14 12.1 0.6 3.1 2 1 0 2 2 2 2 PAN domain DEK_C PF08766.11 KOO53694.1 - 8.9e-09 35.1 0.4 1.3e-08 34.7 0.4 1.2 1 0 0 1 1 1 1 DEK C terminal domain Glyco_hydro_47 PF01532.20 KOO53696.1 - 1.4e-82 278.1 0.0 1.8e-82 277.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 RNA_pol_3_Rpc31 PF11705.8 KOO53697.1 - 1.1e-05 25.8 11.0 0.00011 22.6 11.0 1.9 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 LRR_6 PF13516.6 KOO53698.1 - 8.7e-72 231.2 23.2 7.9e-06 25.5 0.1 13.5 14 0 0 14 14 13 12 Leucine Rich repeat LRR_4 PF12799.7 KOO53698.1 - 3.8e-10 39.8 11.8 0.87 10.1 0.0 8.6 3 3 6 10 10 10 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOO53698.1 - 6.8e-08 32.0 0.0 1.5e+02 3.5 0.0 9.0 10 0 0 10 10 10 0 Leucine Rich Repeat LRR_8 PF13855.6 KOO53698.1 - 7.3e-05 22.4 11.7 16 5.4 0.1 8.8 6 3 2 8 8 8 0 Leucine rich repeat EIF_2_alpha PF07541.12 KOO53698.1 - 0.0075 16.4 5.6 5.7 7.1 0.0 4.9 2 2 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit YusW PF14039.6 KOO53698.1 - 0.024 15.2 2.3 50 4.5 0.1 5.1 1 1 7 8 8 8 0 YusW-like protein DUF4396 PF14342.6 KOO53698.1 - 0.028 14.8 2.3 6.6 7.1 0.0 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4396) SpoU_sub_bind PF08032.12 KOO53698.1 - 0.14 12.5 9.8 7.4 6.9 0.1 5.7 5 2 2 7 7 7 0 RNA 2'-O ribose methyltransferase substrate binding Phage_TAC_2 PF06894.11 KOO53698.1 - 0.36 10.6 2.4 6.1 6.7 0.3 3.8 2 2 0 2 2 2 0 Bacteriophage lambda tail assembly chaperone, TAC, protein G Arm-DNA-bind_1 PF09003.10 KOO53698.1 - 0.98 9.6 33.5 28 4.9 0.1 9.7 5 3 7 12 12 11 0 Bacteriophage lambda integrase, Arm DNA-binding domain DUF3107 PF11305.8 KOO53698.1 - 0.98 9.7 8.1 16 5.8 0.2 5.3 3 3 4 7 7 7 0 Protein of unknown function (DUF3107) HTH_3 PF01381.22 KOO53698.1 - 3.9 7.6 9.7 5.7 7.1 0.1 5.5 8 0 0 8 8 8 0 Helix-turn-helix SpoVAB PF13782.6 KOO53698.1 - 5.8 7.3 6.9 54 4.1 0.0 4.5 5 0 0 5 5 5 0 Stage V sporulation protein AB Pkinase PF00069.25 KOO53699.1 - 9.5e-52 176.0 0.0 1.4e-51 175.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53699.1 - 5.8e-17 61.8 0.0 9.2e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO53699.1 - 1.2e-06 28.1 0.4 0.0062 15.9 0.2 2.9 1 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KOO53699.1 - 8.9e-06 24.7 0.2 0.00012 21.0 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KOO53699.1 - 0.00012 22.1 13.3 0.00021 21.3 0.0 3.8 3 1 1 4 4 4 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 KOO53699.1 - 0.0014 18.2 0.0 0.0014 18.2 0.0 2.3 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.14 KOO53699.1 - 0.0014 18.0 0.0 0.0028 17.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOO53699.1 - 0.0047 16.5 0.0 0.0086 15.7 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Presenilin PF01080.17 KOO53699.1 - 9 4.9 6.7 12 4.5 6.7 1.1 1 0 0 1 1 1 0 Presenilin MPS2 PF17060.5 KOO53700.1 - 3.5 6.8 10.4 0.25 10.5 4.5 2.2 2 0 0 2 2 2 0 Monopolar spindle protein 2 CRC_subunit PF08624.10 KOO53701.1 - 0.0089 16.5 0.3 0.18 12.3 0.0 2.5 3 0 0 3 3 3 1 Chromatin remodelling complex Rsc7/Swp82 subunit Sigma70_r2 PF04542.14 KOO53702.1 - 1.3e-18 66.5 0.1 2.9e-18 65.4 0.1 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r3 PF04539.16 KOO53702.1 - 1.6e-16 60.2 1.4 3.2e-08 33.6 0.0 2.4 2 0 0 2 2 2 2 Sigma-70 region 3 Sigma70_r1_2 PF00140.20 KOO53702.1 - 3.9e-08 33.2 0.0 9e-08 32.0 0.0 1.7 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 DUF3071 PF11268.8 KOO53702.1 - 0.025 14.6 0.5 0.053 13.6 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) DUF742 PF05331.11 KOO53702.1 - 0.034 13.9 0.1 1.5 8.6 0.0 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF742) Ank_5 PF13857.6 KOO53703.1 - 0.00013 22.2 0.4 0.0027 18.0 0.1 2.4 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO53703.1 - 0.00062 20.3 0.0 0.0013 19.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO53703.1 - 0.00067 19.9 0.1 0.063 13.9 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 KOO53703.1 - 0.0075 16.8 0.0 0.015 15.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOO53703.1 - 0.045 14.2 0.3 0.54 10.8 0.1 2.6 2 0 0 2 2 2 0 Ankyrin repeat EMC3_TMCO1 PF01956.16 KOO53704.1 - 2.8e-19 69.5 0.0 5.1e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like DSHCT PF08148.12 KOO53705.1 - 4.7e-13 49.1 0.0 1.2e-12 47.8 0.0 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 KOO53705.1 - 3.2e-08 33.5 0.1 7.5e-08 32.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO53705.1 - 9.2e-07 29.2 0.0 2.6e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO53705.1 - 0.00026 21.0 0.0 0.00042 20.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 KOO53705.1 - 0.096 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea FAM184 PF15665.5 KOO53706.1 - 0.01 15.6 5.7 0.023 14.5 5.7 1.6 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Golgin_A5 PF09787.9 KOO53706.1 - 0.044 13.3 1.7 0.081 12.4 1.7 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 MORN PF02493.20 KOO53706.1 - 0.065 13.1 4.1 1.1 9.3 0.8 2.4 2 0 0 2 2 2 0 MORN repeat Syntaxin PF00804.25 KOO53706.1 - 0.95 9.1 6.8 0.47 10.1 2.9 2.0 1 1 1 2 2 2 0 Syntaxin Ax_dynein_light PF10211.9 KOO53706.1 - 1.5 8.7 8.9 0.34 10.8 5.2 1.8 2 0 0 2 2 2 0 Axonemal dynein light chain HALZ PF02183.18 KOO53706.1 - 6.2 7.1 14.2 1.5e+02 2.7 7.9 4.1 3 1 0 3 3 3 0 Homeobox associated leucine zipper Pyr_redox_2 PF07992.14 KOO53708.1 - 3.8e-07 29.6 0.0 0.00063 19.1 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase acVLRF1 PF18859.1 KOO53708.1 - 3.4 8.0 6.9 0.55 10.5 1.1 2.3 2 0 0 2 2 2 0 Actinobacteria/chloroflexi VLRF1 release factor GILT PF03227.16 KOO53709.1 - 0.0021 18.3 1.4 0.0047 17.1 1.4 1.7 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) DHC_N1 PF08385.12 KOO53710.1 - 2.2e-145 485.5 0.0 6.4e-145 484.0 0.0 1.8 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 KOO53710.1 - 7.9e-135 449.0 0.0 9.3e-133 442.2 0.0 2.9 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOO53710.1 - 7.4e-96 321.7 2.4 7.4e-96 321.7 2.4 3.9 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KOO53710.1 - 5.3e-76 255.4 0.0 1.3e-75 254.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 KOO53710.1 - 8.4e-61 204.6 1.0 1.6e-58 197.2 0.1 3.2 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_1 PF17857.1 KOO53710.1 - 9e-24 83.6 0.3 3.8e-23 81.6 0.1 2.3 2 0 0 2 2 2 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 KOO53710.1 - 1.4e-21 76.9 0.0 7.7e-21 74.5 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KOO53710.1 - 1.1e-15 57.8 0.0 1.6e-06 28.2 0.0 5.4 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.29 KOO53710.1 - 0.00073 20.0 0.1 6 7.3 0.0 3.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOO53710.1 - 0.068 13.5 2.6 28 5.0 0.0 5.0 5 0 0 5 5 5 0 AAA ATPase domain Sec1 PF00995.23 KOO53711.1 - 2.5e-127 426.6 0.1 2.8e-127 426.4 0.1 1.0 1 0 0 1 1 1 1 Sec1 family Peptidase_C2 PF00648.21 KOO53712.1 - 2.3e-44 151.6 0.0 3.7e-43 147.7 0.0 2.1 1 1 0 1 1 1 1 Calpain family cysteine protease SET PF00856.28 KOO53715.1 - 0.002 18.6 0.4 0.0054 17.1 0.1 1.9 2 1 0 2 2 2 1 SET domain AlaDh_PNT_C PF01262.21 KOO53715.1 - 0.8 9.0 10.1 3.7 6.8 0.2 3.2 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain TPR_12 PF13424.6 KOO53715.1 - 3.1 8.2 9.1 1.2 9.5 3.7 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat NAAA-beta PF15508.6 KOO53716.1 - 0.00042 20.6 0.0 0.00087 19.5 0.0 1.5 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase FAD_binding_4 PF01565.23 KOO53717.1 - 1.7e-10 40.8 0.1 2.8e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain PPR_2 PF13041.6 KOO53718.1 - 1.4e-38 130.8 0.0 3e-09 36.9 0.0 6.9 5 1 2 7 7 7 6 PPR repeat family PPR PF01535.20 KOO53718.1 - 2.2e-28 96.5 0.0 0.0001 22.3 0.0 9.0 10 0 0 10 10 10 6 PPR repeat PPR_1 PF12854.7 KOO53718.1 - 1.1e-25 89.0 0.0 0.0001 21.9 0.0 7.5 7 0 0 7 7 7 5 PPR repeat PPR_3 PF13812.6 KOO53718.1 - 4.5e-25 87.5 0.0 4.5e-05 23.4 0.0 6.3 4 2 3 7 7 7 6 Pentatricopeptide repeat domain PPR_long PF17177.4 KOO53718.1 - 1.9e-15 56.9 8.3 1.4e-09 37.7 4.2 3.5 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP T2SSF PF00482.23 KOO53718.1 - 0.014 15.3 4.4 0.84 9.6 0.4 3.1 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F TPR_14 PF13428.6 KOO53718.1 - 2.3 9.3 38.4 10 7.3 0.1 8.6 4 2 4 9 9 9 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53718.1 - 3.4 8.0 8.3 13 6.1 0.4 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat MORN PF02493.20 KOO53719.1 - 0.037 13.9 0.3 3.1 7.9 0.0 3.0 3 0 0 3 3 3 0 MORN repeat ADK PF00406.22 KOO53720.1 - 2e-20 73.4 0.0 2.9e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOO53720.1 - 4.1e-07 30.5 0.0 1.1e-06 29.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain NUDIX PF00293.28 KOO53720.1 - 0.0058 16.7 0.0 0.019 15.0 0.0 1.8 2 0 0 2 2 2 1 NUDIX domain LRR_5 PF13306.6 KOO53723.1 - 7.3e-89 294.3 0.0 3.9e-33 114.1 0.0 3.0 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO53723.1 - 9.1e-17 60.6 0.0 0.0051 16.5 0.0 7.2 1 1 9 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 KOO53723.1 - 0.007 16.8 1.8 2.4e+02 2.3 0.1 6.9 6 2 2 9 9 9 0 Leucine Rich repeats (2 copies) He_PIG PF05345.12 KOO53723.1 - 0.18 12.0 21.5 36 4.6 0.1 8.7 6 3 4 10 10 10 0 Putative Ig domain Peptidase_M8 PF01457.16 KOO53723.1 - 2 7.0 5.0 21 3.7 0.1 3.8 3 2 1 4 4 4 0 Leishmanolysin Forkhead_N PF08430.12 KOO53723.1 - 3.1 8.4 17.5 64 4.2 8.1 3.3 1 1 1 2 2 2 0 Forkhead N-terminal region Eno-Rase_NADH_b PF12242.8 KOO53723.1 - 6.7 6.6 6.3 27 4.6 0.7 2.5 1 1 1 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Erythro_esteras PF05139.14 KOO53724.1 - 5.8e-84 282.8 1.3 5.8e-82 276.3 1.3 2.1 1 1 0 1 1 1 1 Erythromycin esterase FAD_oxidored PF12831.7 KOO53725.1 - 2.4e-71 241.4 0.1 2.7e-71 241.2 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOO53725.1 - 0.0045 16.1 0.0 0.0045 16.1 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain COMM_domain PF07258.14 KOO53726.1 - 1.2e-05 25.3 0.0 1.7e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 COMM domain DUF2937 PF11157.8 KOO53727.1 - 0.0044 16.8 0.7 0.3 10.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2937) CorA PF01544.18 KOO53727.1 - 7.6 5.7 6.8 47 3.2 6.8 2.2 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein GLTP PF08718.11 KOO53728.1 - 2e-26 93.0 0.0 2.8e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) PWWP PF00855.17 KOO53729.1 - 8.4e-10 38.9 0.0 1.9e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 PWWP domain Kelch_5 PF13854.6 KOO53733.1 - 4.3e-28 96.8 0.7 5.1e-06 26.3 0.1 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KOO53733.1 - 1.5e-23 82.5 4.7 8.5e-05 22.5 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KOO53733.1 - 2.8e-16 59.3 7.5 0.00027 21.1 0.0 6.6 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 KOO53733.1 - 1.2e-11 44.5 1.8 0.00012 22.2 0.0 5.1 5 1 1 6 6 6 3 Kelch motif Kelch_2 PF07646.15 KOO53733.1 - 1.3e-11 44.0 4.2 0.032 14.2 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 KOO53733.1 - 1.1e-05 24.9 4.0 0.09 12.4 0.0 4.9 6 1 0 6 6 6 2 Kelch motif RAG2 PF03089.14 KOO53733.1 - 0.19 10.6 0.0 3.5 6.5 0.0 2.8 2 1 1 3 3 3 0 Recombination activating protein 2 CRAL_TRIO PF00650.20 KOO53734.1 - 2.9e-24 85.6 0.0 4.3e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KOO53734.1 - 0.19 11.9 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Tau95 PF09734.9 KOO53736.1 - 6.7e-28 98.2 0.1 1e-27 97.7 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 KOO53736.1 - 3.8e-22 78.8 0.0 6.9e-21 74.8 0.0 2.1 1 1 0 1 1 1 1 Tau95 Triple barrel domain ResIII PF04851.15 KOO53737.1 - 1.5e-22 80.4 0.0 1.8e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOO53737.1 - 1.7e-12 47.4 0.0 2.2e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 KOO53737.1 - 1.3e-06 28.3 0.0 1.7e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 SWI2/SNF2 ATPase Flavi_DEAD PF07652.14 KOO53737.1 - 0.0023 17.9 0.0 0.0032 17.5 0.0 1.2 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_30 PF13604.6 KOO53737.1 - 0.013 15.3 0.1 0.018 14.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain P-II PF00543.22 KOO53737.1 - 0.1 13.2 0.0 0.16 12.6 0.0 1.3 1 0 0 1 1 1 0 Nitrogen regulatory protein P-II Mpv17_PMP22 PF04117.12 KOO53738.1 - 1.2e-07 31.8 0.1 4.2e-07 30.1 0.0 1.9 1 1 1 2 2 2 1 Mpv17 / PMP22 family MORN PF02493.20 KOO53739.1 - 9.1e-47 154.2 40.3 7e-08 31.9 0.5 9.9 9 1 1 10 10 10 9 MORN repeat DUF3048_C PF17479.2 KOO53739.1 - 0.1 13.0 15.9 0.86 10.0 1.6 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF3048) C-terminal domain SBBP PF06739.11 KOO53740.1 - 2.5e-11 43.4 38.8 0.00022 21.2 0.8 6.9 6 0 0 6 6 6 6 Beta-propeller repeat Bombesin PF02044.17 KOO53740.1 - 0.14 12.2 1.3 9.8 6.5 0.1 4.5 3 0 0 3 3 3 0 Bombesin-like peptide Pkinase_Tyr PF07714.17 KOO53741.1 - 1.6e-29 103.0 0.0 3e-29 102.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KOO53741.1 - 3.5e-29 102.0 0.0 6e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain LRR_4 PF12799.7 KOO53741.1 - 9.3e-08 32.3 1.8 0.00018 21.8 0.0 2.2 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOO53741.1 - 1.9e-07 30.7 0.1 4.1e-07 29.7 0.1 1.5 1 0 0 1 1 1 1 Leucine rich repeat RRM_1 PF00076.22 KOO53741.1 - 0.037 13.9 0.1 0.14 12.0 0.1 2.0 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinase-like PF14531.6 KOO53741.1 - 0.047 13.0 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 KOO53741.1 - 0.11 12.4 1.6 0.34 10.8 0.4 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family LRR_6 PF13516.6 KOO53741.1 - 0.17 12.0 0.1 1.8 8.9 0.0 2.7 2 0 0 2 2 2 0 Leucine Rich repeat TPR_12 PF13424.6 KOO53742.1 - 1.5e-15 57.3 0.1 2.3e-08 34.2 0.2 5.1 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOO53742.1 - 4.4e-08 32.8 0.0 4.4e-08 32.8 0.0 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat PDZ PF00595.24 KOO53742.1 - 4.2e-07 30.2 0.1 1.3e-06 28.6 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOO53742.1 - 7e-05 23.1 0.2 0.0015 18.8 0.1 2.7 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KOO53742.1 - 0.00039 20.2 0.0 0.0012 18.6 0.0 1.9 1 0 0 1 1 1 1 PDZ domain Spc7 PF08317.11 KOO53742.1 - 0.23 10.3 40.1 0.23 10.3 9.2 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF1054 PF06335.12 KOO53742.1 - 5.9 6.8 8.5 15 5.5 8.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1054) Neisseria_TspB PF05616.13 KOO53742.1 - 6.8 5.0 9.1 12 4.3 9.1 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Adenine_glyco PF03352.13 KOO53743.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Methyladenine glycosylase TerD PF02342.18 KOO53746.1 - 9.7e-11 41.5 0.0 2.2e-10 40.3 0.0 1.5 1 1 0 1 1 1 1 TerD domain F-box-like PF12937.7 KOO53746.1 - 0.012 15.5 1.0 0.035 14.0 1.0 1.8 1 0 0 1 1 1 0 F-box-like PGA2 PF07543.12 KOO53746.1 - 0.091 12.7 1.6 0.21 11.6 1.6 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 Helicase_C PF00271.31 KOO53747.1 - 3.6e-12 46.6 0.0 7e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KOO53748.1 - 6.8e-47 159.9 0.2 3.6e-46 157.5 0.2 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain HEAT_2 PF13646.6 KOO53748.1 - 0.00011 22.5 2.0 0.00011 22.5 2.0 2.8 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 KOO53748.1 - 0.04 14.2 0.1 0.04 14.2 0.1 3.9 4 0 0 4 4 4 0 HEAT repeat Sugar_tr PF00083.24 KOO53751.1 - 3.5e-87 293.1 13.2 4.2e-87 292.9 13.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOO53751.1 - 3.5e-27 95.2 43.2 1e-21 77.3 16.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KOO53751.1 - 2.4e-05 23.0 2.2 2.4e-05 23.0 2.2 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 KOO53751.1 - 0.13 10.5 5.0 0.43 8.8 0.2 2.5 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF4558 PF15104.6 KOO53753.1 - 5.9e-12 45.5 5.9 5.9e-12 45.5 5.9 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4558) HWE_HK PF07536.14 KOO53753.1 - 0.017 15.8 1.2 0.073 13.8 0.7 1.9 1 1 0 2 2 2 0 HWE histidine kinase TMF_TATA_bd PF12325.8 KOO53754.1 - 0.0073 16.5 3.0 0.0076 16.5 1.9 1.6 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding Siah-Interact_N PF09032.11 KOO53754.1 - 0.13 12.6 1.9 0.24 11.8 1.9 1.5 1 0 0 1 1 1 0 Siah interacting protein, N terminal Acid_PPase PF12689.7 KOO53755.1 - 4.6e-23 81.9 0.0 8.3e-23 81.1 0.0 1.4 1 1 0 1 1 1 1 Acid Phosphatase RRM_1 PF00076.22 KOO53757.1 - 1.8e-19 69.3 0.0 5.6e-19 67.7 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAST_1 PF06743.15 KOO53757.1 - 2e-17 62.9 0.0 0.068 13.1 0.0 6.2 2 2 4 6 6 6 5 FAST kinase-like protein, subdomain 1 DUF1601 PF07671.11 KOO53757.1 - 9.5e-11 41.4 10.2 0.12 12.2 0.4 6.1 5 1 1 6 6 6 4 Protein of unknown function (DUF1601) RAP PF08373.10 KOO53757.1 - 1.2e-10 41.3 0.0 2.8e-10 40.1 0.0 1.6 1 1 0 1 1 1 1 RAP domain Ank_5 PF13857.6 KOO53757.1 - 1.3e-09 38.1 0.1 6.8e-09 35.8 0.1 2.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOO53757.1 - 5.7e-09 36.4 0.0 2.1e-07 31.5 0.0 3.4 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO53757.1 - 6.1e-08 33.1 0.3 3.1e-05 24.4 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO53757.1 - 3.6e-06 27.2 0.1 0.00022 21.5 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 KOO53757.1 - 2.5e-05 24.3 0.0 0.0014 18.9 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat RRM_Rrp7 PF17799.1 KOO53757.1 - 0.0051 16.6 0.0 0.0088 15.9 0.0 1.3 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RsdA_SigD_bd PF16751.5 KOO53757.1 - 0.085 13.1 24.7 18 5.7 0.0 8.6 9 0 0 9 9 9 0 Anti-sigma-D factor RsdA to sigma factor binding region Ank_2 PF12796.7 KOO53758.1 - 0.0005 20.6 0.0 0.077 13.6 0.0 3.2 1 1 2 3 3 3 1 Ankyrin repeats (3 copies) Ion_trans PF00520.31 KOO53758.1 - 0.0012 18.2 11.5 0.0012 18.2 11.5 2.6 2 1 0 2 2 2 2 Ion transport protein Ank_3 PF13606.6 KOO53758.1 - 0.0025 18.2 0.4 0.53 11.0 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat TMPIT PF07851.13 KOO53758.1 - 0.089 12.0 1.8 0.2 10.8 1.8 1.5 1 0 0 1 1 1 0 TMPIT-like protein Ank PF00023.30 KOO53758.1 - 3.6 8.2 5.0 60 4.3 0.0 4.4 6 0 0 6 6 6 0 Ankyrin repeat Phage_integrase PF00589.22 KOO53759.1 - 0.00034 20.5 0.0 0.00058 19.7 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family DUF3007 PF11460.8 KOO53760.1 - 4.9e-24 84.4 0.3 6.5e-24 84.0 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3007) SNARE PF05739.19 KOO53761.1 - 1.2e-14 54.0 0.3 3.7e-14 52.5 0.3 1.9 1 0 0 1 1 1 1 SNARE domain GBP PF02263.19 KOO53761.1 - 0.00015 21.2 0.0 0.00056 19.3 0.0 2.0 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain Syntaxin_2 PF14523.6 KOO53761.1 - 0.0013 19.0 3.0 0.0039 17.5 0.3 2.5 2 0 0 2 2 2 1 Syntaxin-like protein Syntaxin PF00804.25 KOO53761.1 - 0.021 14.5 7.8 0.063 12.9 0.5 2.8 3 0 0 3 3 3 0 Syntaxin Prominin PF05478.11 KOO53761.1 - 0.076 11.0 0.5 0.14 10.1 0.5 1.3 1 0 0 1 1 1 0 Prominin INCENP_ARK-bind PF03941.15 KOO53761.1 - 0.1 12.6 0.2 0.51 10.3 0.2 2.2 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region Dynein_C PF18199.1 KOO53762.1 - 9.6e-16 57.9 0.8 3e-15 56.2 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain SAM_1 PF00536.30 KOO53762.1 - 3.6e-11 43.3 0.0 7.7e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KOO53762.1 - 2.8e-09 37.0 0.0 5.9e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Cyclin PF08613.11 KOO53762.1 - 4.8e-09 36.8 0.0 9.6e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KOO53762.1 - 3.3e-08 33.3 0.4 7.7e-08 32.1 0.4 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Unstab_antitox PF09720.10 KOO53762.1 - 0.22 11.6 0.1 0.22 11.6 0.1 2.2 2 1 0 2 2 2 0 Putative addiction module component DUF349 PF03993.12 KOO53762.1 - 1 9.7 6.4 2.7 8.4 6.4 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Sulfotransfer_2 PF03567.14 KOO53763.1 - 0.012 15.5 0.0 0.13 12.1 0.0 2.3 1 1 0 1 1 1 0 Sulfotransferase family WD40 PF00400.32 KOO53764.1 - 1.8e-08 34.9 0.5 0.0039 18.0 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOO53764.1 - 0.0075 16.5 0.0 0.86 9.9 0.0 2.8 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Cofac_haem_bdg PF04187.13 KOO53765.1 - 2.2e-22 80.1 0.1 1.2e-20 74.4 0.0 2.5 1 1 1 2 2 2 1 Haem-binding uptake, Tiki superfamily, ChaN Sel1 PF08238.12 KOO53765.1 - 1.2e-13 51.3 0.2 3.4e-06 27.6 0.1 3.7 3 0 0 3 3 3 3 Sel1 repeat Patatin PF01734.22 KOO53765.1 - 8.8e-05 22.8 0.0 0.0003 21.0 0.0 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase CopC PF04234.12 KOO53766.1 - 0.046 14.8 0.9 0.12 13.4 0.9 1.8 1 1 0 1 1 1 0 CopC domain Asparaginase PF00710.20 KOO53767.1 - 7e-59 198.6 0.0 1.1e-58 198.0 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 KOO53767.1 - 1.3e-28 99.4 0.0 2.4e-28 98.6 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain HEAT PF02985.22 KOO53768.1 - 1.4e-13 49.8 8.2 0.015 15.5 0.2 6.1 5 0 0 5 5 5 5 HEAT repeat Pkinase PF00069.25 KOO53768.1 - 2.7e-11 43.3 0.0 6.5e-11 42.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain HEAT_2 PF13646.6 KOO53768.1 - 8.7e-08 32.5 6.3 0.0043 17.4 0.8 4.8 3 2 1 4 4 4 3 HEAT repeats APH PF01636.23 KOO53768.1 - 0.00019 21.5 0.4 0.0074 16.2 0.1 3.1 1 1 2 3 3 3 1 Phosphotransferase enzyme family HEAT_EZ PF13513.6 KOO53768.1 - 0.00021 21.7 6.8 0.35 11.4 0.1 5.2 3 1 1 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 KOO53768.1 - 0.003 17.6 0.0 38 4.3 0.0 4.0 3 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Pkinase_Tyr PF07714.17 KOO53768.1 - 0.0074 15.6 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 KOO53768.1 - 0.01 16.7 0.3 0.89 10.5 0.0 3.0 2 0 0 2 2 2 0 WD domain, G-beta repeat Adaptin_N PF01602.20 KOO53768.1 - 0.031 12.8 0.7 2.4 6.6 0.1 2.3 1 1 0 2 2 2 0 Adaptin N terminal region PQQ_2 PF13360.6 KOO53768.1 - 0.13 11.8 0.1 0.39 10.2 0.0 1.8 2 0 0 2 2 2 0 PQQ-like domain DRIM PF07539.12 KOO53768.1 - 0.18 10.1 1.8 0.26 9.6 0.4 1.8 2 0 0 2 2 2 0 Down-regulated in metastasis TPR_2 PF07719.17 KOO53769.1 - 9.6e-11 41.0 13.4 0.0058 16.6 0.1 4.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOO53769.1 - 7.9e-08 31.8 10.5 0.0029 17.3 0.6 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat UBA PF00627.31 KOO53769.1 - 8.8e-05 22.3 0.1 0.00023 21.0 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain TPR_8 PF13181.6 KOO53769.1 - 9.2e-05 22.4 6.2 0.077 13.2 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOO53769.1 - 0.00042 20.5 11.2 0.01 16.1 2.6 3.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOO53769.1 - 0.089 12.5 9.4 0.1 12.3 1.5 3.0 2 1 1 3 3 3 0 TPR repeat Glyco_transf_8C PF08437.10 KOO53769.1 - 0.15 12.1 0.4 3.3 7.9 0.1 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 8 C-terminal TPR_7 PF13176.6 KOO53769.1 - 0.7 10.1 6.3 18 5.6 0.1 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat Glycohydro_20b2 PF14845.6 KOO53769.1 - 2.6 8.7 6.6 1.1 9.9 0.4 2.6 3 0 0 3 3 3 0 beta-acetyl hexosaminidase like EF-hand_1 PF00036.32 KOO53770.1 - 0.00022 20.6 0.0 0.00041 19.7 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOO53770.1 - 0.00046 19.6 0.0 0.00083 18.7 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOO53770.1 - 0.012 16.1 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KOO53770.1 - 0.033 14.1 0.0 0.072 13.1 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain SH3_3 PF08239.11 KOO53772.1 - 4.7e-05 23.6 0.1 0.00011 22.3 0.1 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.13 KOO53772.1 - 0.0035 17.1 0.0 0.0092 15.8 0.0 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain Nucleoporin_FG PF13634.6 KOO53772.1 - 4.5 8.2 6.0 0.57 11.1 0.4 2.3 2 0 0 2 2 2 0 Nucleoporin FG repeat region WD40 PF00400.32 KOO53773.1 - 0.00024 21.8 0.2 0.053 14.4 0.0 3.8 4 0 0 4 4 4 1 WD domain, G-beta repeat FapA PF03961.13 KOO53773.1 - 2.8 6.5 5.8 4.8 5.7 5.8 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A PP2C PF00481.21 KOO53776.1 - 3.5e-34 118.6 0.0 9.2e-34 117.2 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOO53776.1 - 5.1 6.7 9.0 0.9 9.1 4.5 1.9 2 1 0 2 2 2 0 Protein phosphatase 2C SesA PF17107.5 KOO53778.1 - 0.0048 17.1 0.1 0.018 15.2 0.1 2.0 2 1 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Methyltransf_22 PF13383.6 KOO53779.1 - 1.4e-13 51.1 0.0 1.6e-08 34.4 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain CRAL_TRIO PF00650.20 KOO53779.1 - 2.1e-10 40.5 0.0 3.7e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Methyltransf_21 PF05050.12 KOO53779.1 - 2.7e-05 24.3 0.0 7.2e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase FkbM domain Stealth_CR2 PF11380.8 KOO53780.1 - 2.8e-13 50.0 0.0 1.5e-12 47.6 0.0 2.0 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 KOO53780.1 - 7.2e-12 45.0 2.5 7.2e-12 45.0 2.5 1.7 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 LptC PF06835.13 KOO53780.1 - 0.18 11.4 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide-assembly, LptC-related Laminin_G_3 PF13385.6 KOO53781.1 - 0.00012 22.3 0.0 0.00021 21.5 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EF-hand_5 PF13202.6 KOO53781.1 - 0.0026 17.2 0.5 0.008 15.6 0.2 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KOO53781.1 - 0.014 15.3 0.1 0.053 13.5 0.1 2.1 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 KOO53781.1 - 0.041 13.4 1.0 0.12 11.9 0.2 2.3 2 0 0 2 2 2 0 EF hand C2 PF00168.30 KOO53782.1 - 2.5e-16 59.8 0.0 5.4e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain Ion_trans PF00520.31 KOO53782.1 - 1.2e-14 54.1 4.5 1.8e-14 53.6 4.5 1.3 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 KOO53782.1 - 0.00034 20.6 0.0 0.00064 19.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Lig_chan PF00060.26 KOO53782.1 - 0.19 11.6 4.1 0.11 12.3 0.1 2.2 2 0 0 2 2 2 0 Ligand-gated ion channel IDO PF01231.18 KOO53782.1 - 0.2 10.4 0.0 0.38 9.5 0.0 1.4 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase Ribosomal_60s PF00428.19 KOO53782.1 - 0.25 12.0 2.8 0.95 10.1 2.8 2.0 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF2207 PF09972.9 KOO53782.1 - 8.6 5.0 5.6 1.8 7.2 0.6 2.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Methyltransf_23 PF13489.6 KOO53783.1 - 2.3e-05 24.3 0.0 2.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOO53783.1 - 0.0044 17.7 0.0 0.0057 17.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO53783.1 - 0.0094 16.6 0.0 0.018 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FWWh PF14922.6 KOO53785.1 - 1.2e-12 48.0 0.0 2.4e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function ADP_ribosyl_GH PF03747.14 KOO53785.1 - 0.014 15.2 0.4 0.023 14.5 0.4 1.3 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase Filamin PF00630.19 KOO53787.1 - 3.5e-12 47.0 0.0 5.5e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Filamin/ABP280 repeat Peptidase_M36 PF02128.15 KOO53787.1 - 0.061 12.5 0.5 0.11 11.7 0.5 1.3 1 0 0 1 1 1 0 Fungalysin metallopeptidase (M36) DUF3725 PF12523.8 KOO53787.1 - 0.14 12.5 0.1 0.31 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) TerB_C PF15615.6 KOO53788.1 - 0.42 10.9 6.1 0.096 13.0 2.4 2.0 2 1 0 2 2 2 0 TerB-C domain DUF2152 PF10222.9 KOO53789.1 - 0.099 11.0 0.0 0.21 9.9 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2152) TPR_1 PF00515.28 KOO53789.1 - 0.39 10.6 3.8 50 4.0 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat RCC1 PF00415.18 KOO53790.1 - 2.7e-35 120.8 26.2 5.1e-06 27.0 0.3 6.6 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOO53790.1 - 7.6e-29 98.9 44.8 2.6e-06 27.0 1.4 6.3 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat URO-D PF01208.17 KOO53792.1 - 4.2e-97 325.4 0.0 7.4e-97 324.6 0.0 1.3 2 0 0 2 2 2 1 Uroporphyrinogen decarboxylase (URO-D) DEAD PF00270.29 KOO53794.1 - 5.3e-13 49.1 0.0 1.2e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO53794.1 - 4.9e-11 42.9 0.0 1.1e-09 38.5 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO53794.1 - 0.011 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TauE PF01925.19 KOO53795.1 - 2.3e-25 89.6 34.1 5.3e-13 49.1 5.9 2.2 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE EF-hand_6 PF13405.6 KOO53796.1 - 2e-31 105.2 3.8 8.4e-07 28.4 0.0 7.4 6 0 0 6 6 6 5 EF-hand domain EF-hand_1 PF00036.32 KOO53796.1 - 3.3e-31 104.5 6.1 1.9e-06 27.0 0.1 6.9 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KOO53796.1 - 4.4e-27 94.3 6.8 1.1e-09 38.6 0.4 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO53796.1 - 9.5e-20 69.2 5.8 0.0016 17.9 0.5 6.4 5 0 0 5 5 5 5 EF hand Pentapeptide_4 PF13599.6 KOO53796.1 - 5.2e-13 49.0 0.0 0.0091 16.1 0.0 5.6 4 2 2 6 6 6 4 Pentapeptide repeats (9 copies) EF-hand_10 PF14788.6 KOO53796.1 - 1.3e-07 31.4 3.9 0.0018 18.1 0.1 4.3 4 2 2 6 6 6 2 EF hand EF-hand_8 PF13833.6 KOO53796.1 - 3.4e-06 26.8 9.4 0.29 11.0 0.1 6.8 5 2 2 7 7 7 4 EF-hand domain pair SinI PF08671.10 KOO53796.1 - 0.012 15.4 0.0 0.066 13.0 0.0 2.4 2 0 0 2 2 2 0 Anti-repressor SinI TrkH PF02386.16 KOO53796.1 - 0.013 13.9 0.4 0.022 13.2 0.4 1.2 1 0 0 1 1 1 0 Cation transport protein Phage_tail_3 PF08813.11 KOO53796.1 - 0.054 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Phage tail tube protein, TTP EF-hand_9 PF14658.6 KOO53796.1 - 0.12 12.8 0.1 9.3 6.7 0.0 3.3 2 0 0 2 2 2 0 EF-hand domain Ribosomal_L13e PF01294.18 KOO53796.1 - 0.23 11.3 5.4 24 4.7 0.1 5.9 5 1 0 5 5 5 0 Ribosomal protein L13e EF-hand_14 PF17959.1 KOO53796.1 - 0.32 11.4 1.4 11 6.5 0.3 3.1 2 0 0 2 2 2 0 EF-hand domain MlrC_C PF07171.12 KOO53797.1 - 0.058 13.6 1.0 0.13 12.5 1.0 1.5 1 0 0 1 1 1 0 MlrC C-terminus Atg14 PF10186.9 KOO53797.1 - 0.32 10.0 5.5 0.12 11.5 2.5 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 GrpE PF01025.19 KOO53798.1 - 3e-42 144.1 0.0 4.3e-42 143.6 0.0 1.1 1 0 0 1 1 1 1 GrpE Mito_carr PF00153.27 KOO53798.1 - 2.2e-13 49.9 0.0 8e-13 48.1 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial carrier protein PKcGMP_CC PF16808.5 KOO53798.1 - 0.089 12.7 0.4 0.21 11.5 0.4 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Chloroa_b-bind PF00504.21 KOO53799.1 - 1e-21 78.2 0.1 2.3e-21 77.0 0.1 1.6 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Rootletin PF15035.6 KOO53799.1 - 0.13 12.3 1.3 0.29 11.1 1.3 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion EF-hand_6 PF13405.6 KOO53800.1 - 6.8e-24 81.7 0.9 4.5e-05 23.0 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 KOO53800.1 - 2.6e-22 76.6 8.0 7.2e-06 25.2 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOO53800.1 - 3.4e-18 65.9 2.6 6.1e-08 33.0 0.2 4.0 1 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOO53800.1 - 1.4e-15 56.8 2.4 3.1e-07 30.1 0.2 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOO53800.1 - 6e-13 47.6 7.3 0.011 15.2 0.1 4.6 4 0 0 4 4 4 4 EF hand IQ PF00612.27 KOO53800.1 - 4e-12 44.8 50.5 0.029 14.1 0.1 10.5 10 0 0 10 10 10 7 IQ calmodulin-binding motif EF-hand_11 PF08976.11 KOO53800.1 - 0.0032 18.3 0.0 0.43 11.5 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain DUF2058 PF09831.9 KOO53802.1 - 0.098 12.8 3.1 0.11 12.7 3.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) PC_rep PF01851.22 KOO53804.1 - 3.1e-38 128.3 18.3 6.2e-07 29.5 0.2 8.7 9 0 0 9 9 9 6 Proteasome/cyclosome repeat RPN2_C PF18004.1 KOO53804.1 - 4.6e-27 94.9 2.3 4.3e-26 91.7 2.3 2.3 1 1 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain HEAT_2 PF13646.6 KOO53804.1 - 2.6e-18 66.2 10.7 5.2e-12 46.0 0.0 5.8 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 KOO53804.1 - 0.00023 21.2 0.1 5.3 7.6 0.1 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 KOO53804.1 - 0.0043 17.5 7.8 0.73 10.4 0.0 5.9 5 1 1 6 6 6 2 HEAT-like repeat MORN PF02493.20 KOO53807.1 - 1.5e-41 137.9 40.7 9.7e-08 31.5 0.9 9.7 9 1 0 9 9 9 7 MORN repeat AIG2_2 PF13772.6 KOO53807.1 - 0.022 15.2 0.0 0.059 13.8 0.0 1.6 1 0 0 1 1 1 0 AIG2-like family DUF3048_C PF17479.2 KOO53807.1 - 0.48 10.8 12.9 0.54 10.7 0.5 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF3048) C-terminal domain ICEA PF05315.11 KOO53807.1 - 0.7 9.3 3.3 11 5.4 0.2 2.6 1 1 2 3 3 3 0 ICEA Protein WD40 PF00400.32 KOO53808.1 - 2.1e-15 56.8 11.3 0.0042 17.9 0.1 6.8 6 2 0 6 6 6 4 WD domain, G-beta repeat rve PF00665.26 KOO53812.1 - 0.0017 18.5 0.1 0.0057 16.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain zf-CDGSH PF09360.10 KOO53812.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 Iron-binding zinc finger CDGSH type ClpS PF02617.17 KOO53813.1 - 8.8e-16 57.5 0.0 1.4e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS Oscp1 PF10188.9 KOO53815.1 - 1.2e-64 217.6 3.6 1.6e-64 217.2 3.6 1.1 1 0 0 1 1 1 1 Organic solute transport protein 1 MMM1 PF10296.9 KOO53815.1 - 0.13 11.3 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Tubulin PF00091.25 KOO53816.1 - 2.5e-48 164.9 0.0 2.8e-48 164.7 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain zf_CCCH_4 PF18345.1 KOO53817.1 - 3.8e-05 23.6 2.6 6.4e-05 22.9 2.6 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KOO53817.1 - 0.048 13.5 3.0 0.084 12.7 3.0 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger zf-CCCH PF00642.24 KOO53817.1 - 0.055 13.4 2.7 0.087 12.8 2.7 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 KOO53819.1 - 4.3e-13 48.9 0.0 6.1e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOO53819.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.5 1 1 0 1 1 1 0 Occluded RNA-recognition motif TIR_2 PF13676.6 KOO53820.1 - 0.00026 21.6 0.0 0.00054 20.5 0.0 1.5 1 0 0 1 1 1 1 TIR domain DUF2786 PF10979.8 KOO53822.1 - 2.7e-08 33.6 4.3 6.4e-08 32.4 4.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2786) UBA_4 PF14555.6 KOO53823.1 - 6.3e-11 41.9 0.1 1.4e-10 40.8 0.1 1.7 1 0 0 1 1 1 1 UBA-like domain SEP PF08059.13 KOO53823.1 - 5e-06 27.0 0.2 0.11 13.0 0.2 4.2 4 1 0 4 4 4 2 SEP domain UBX PF00789.20 KOO53823.1 - 3.1e-05 24.1 0.0 7.3e-05 22.9 0.0 1.6 2 0 0 2 2 2 1 UBX domain Galactosyl_T PF01762.21 KOO53824.1 - 0.091 12.6 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Galactosyltransferase Fringe PF02434.16 KOO53824.1 - 0.17 11.3 0.0 1.2 8.5 0.0 2.0 1 1 0 1 1 1 0 Fringe-like SAM_2 PF07647.17 KOO53825.1 - 0.069 13.3 0.0 0.14 12.3 0.0 1.5 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) MCM2_N PF12619.8 KOO53825.1 - 0.13 12.5 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance protein 2 Na_Ca_ex PF01699.24 KOO53827.1 - 7.4e-32 110.4 36.8 8.7e-18 64.7 13.7 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF2975 PF11188.8 KOO53827.1 - 3.6 7.5 23.3 0.63 9.9 1.8 4.2 3 2 1 4 4 4 0 Protein of unknown function (DUF2975) Ank_2 PF12796.7 KOO53828.1 - 2.9e-11 43.8 0.0 0.00024 21.6 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) DNA_pol_A_exo1 PF01612.20 KOO53828.1 - 1.3e-09 38.0 0.0 2.4e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease Ank_4 PF13637.6 KOO53828.1 - 1.8e-08 34.7 0.4 0.0037 17.8 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO53828.1 - 1.4e-07 31.6 0.1 0.014 15.7 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO53828.1 - 4.6e-05 23.7 0.1 0.091 13.3 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KOO53828.1 - 0.00022 21.4 0.2 0.72 10.6 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat TraG_N PF07916.11 KOO53828.1 - 0.26 10.1 1.1 0.42 9.4 1.1 1.3 1 0 0 1 1 1 0 TraG-like protein, N-terminal region C2 PF00168.30 KOO53829.1 - 2.8e-14 53.3 0.0 5.6e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain EF-hand_6 PF13405.6 KOO53829.1 - 1.3e-10 40.3 0.2 3.2e-07 29.7 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain Ank_2 PF12796.7 KOO53829.1 - 1.1e-09 38.8 0.1 2.1e-09 37.8 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO53829.1 - 2.9e-09 37.3 0.6 6.1e-05 23.5 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO53829.1 - 7.8e-09 35.6 0.6 4.6e-08 33.2 0.4 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) EF-hand_1 PF00036.32 KOO53829.1 - 2.9e-07 29.5 0.1 4.5e-06 25.8 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KOO53829.1 - 1.1e-06 28.9 0.0 2.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair Ank PF00023.30 KOO53829.1 - 2e-06 28.0 0.2 0.00016 22.0 0.2 3.2 3 0 0 3 3 3 1 Ankyrin repeat EF-hand_5 PF13202.6 KOO53829.1 - 5.3e-06 25.7 0.1 4.6e-05 22.7 0.1 2.2 2 0 0 2 2 2 1 EF hand Ank_3 PF13606.6 KOO53829.1 - 3.9e-05 23.7 0.0 0.00082 19.6 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat TetR_C_31 PF17940.1 KOO53829.1 - 0.74 10.0 12.6 0.054 13.7 3.2 3.0 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Transcrip_reg PF01709.20 KOO53831.1 - 8e-61 205.5 1.6 9e-61 205.3 1.6 1.0 1 0 0 1 1 1 1 Transcriptional regulator NT-C2 PF10358.9 KOO53832.1 - 2.1e-07 30.8 0.0 3.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Cep57_CLD_2 PF14197.6 KOO53832.1 - 0.0049 16.9 9.3 0.056 13.5 3.0 2.6 1 1 1 2 2 2 2 Centrosome localisation domain of PPC89 Takusan PF04822.13 KOO53832.1 - 0.17 11.7 5.2 7.2 6.6 0.6 2.6 1 1 1 2 2 2 0 Takusan zf-C4H2 PF10146.9 KOO53832.1 - 0.47 10.7 2.5 0.83 9.9 2.5 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DUF4407 PF14362.6 KOO53832.1 - 1.4 8.2 4.9 2.4 7.4 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CCDC53 PF10152.9 KOO53832.1 - 1.7 9.0 14.2 8.8 6.7 13.9 2.2 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex SOAR PF16533.5 KOO53832.1 - 4.1 7.4 5.9 21 5.2 5.9 2.1 1 1 0 1 1 1 0 STIM1 Orai1-activating region Pkinase PF00069.25 KOO53833.1 - 1.9e-58 197.9 0.0 2.6e-58 197.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOO53833.1 - 1.3e-43 149.1 0.0 1.7e-43 148.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOO53833.1 - 4.8e-05 22.8 0.0 7.5e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOO53833.1 - 0.18 10.6 0.0 0.42 9.3 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Fumerase_C PF05683.12 KOO53837.1 - 6.3e-86 286.9 0.0 1.2e-85 286.0 0.0 1.5 1 0 0 1 1 1 1 Fumarase C-terminus Fumerase PF05681.14 KOO53837.1 - 4.6e-84 282.0 0.0 6.2e-84 281.6 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) IBN_N PF03810.19 KOO53837.1 - 0.021 14.7 0.1 0.045 13.7 0.1 1.5 1 0 0 1 1 1 0 Importin-beta N-terminal domain Ank_2 PF12796.7 KOO53838.1 - 2.1e-43 146.8 12.0 4.1e-15 56.1 0.6 5.0 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO53838.1 - 2.9e-35 120.2 7.4 7.2e-09 36.0 0.2 6.6 5 2 1 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO53838.1 - 2.5e-27 94.6 19.5 9.9e-07 28.9 0.3 8.8 2 1 7 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 KOO53838.1 - 1.2e-26 91.9 23.9 0.001 19.4 0.0 10.1 10 0 0 10 10 10 6 Ankyrin repeat Ank_3 PF13606.6 KOO53838.1 - 1.3e-22 77.4 6.8 0.65 10.7 0.0 9.7 9 0 0 9 9 9 7 Ankyrin repeat F-box PF00646.33 KOO53838.1 - 0.00045 20.0 0.0 0.00092 19.0 0.0 1.5 1 0 0 1 1 1 1 F-box domain GLTT PF01744.20 KOO53838.1 - 0.0098 15.6 3.2 0.028 14.2 3.2 1.8 1 0 0 1 1 1 1 GLTT repeat (6 copies) F-box-like PF12937.7 KOO53838.1 - 0.083 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 F-box-like DUF982 PF06169.12 KOO53840.1 - 0.086 12.9 1.2 0.5 10.4 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF982) DUF3987 PF13148.6 KOO53841.1 - 0.00049 19.2 0.3 0.028 13.4 0.1 2.8 2 1 1 3 3 3 2 Protein of unknown function (DUF3987) SpoVS PF04232.12 KOO53842.1 - 1.8e-44 149.3 4.6 4.9e-27 93.5 0.9 2.4 2 1 0 2 2 2 2 Stage V sporulation protein S (SpoVS) cobW PF02492.19 KOO53843.1 - 4.2e-48 163.3 0.1 5.8e-48 162.8 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KOO53843.1 - 2.7e-06 27.2 0.0 6.2e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 KOO53843.1 - 0.0022 18.0 0.1 0.17 11.8 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase MeaB PF03308.16 KOO53843.1 - 0.0077 15.2 1.1 1.4 7.9 0.0 2.7 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 KOO53843.1 - 0.0079 16.1 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 KOO53843.1 - 0.012 15.9 0.1 0.15 12.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 KOO53843.1 - 0.028 14.8 4.0 0.5 10.7 3.2 3.2 2 1 0 2 2 2 0 AAA ATPase domain TsaE PF02367.17 KOO53843.1 - 0.17 11.9 0.3 0.32 11.0 0.3 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE GTP_EFTU PF00009.27 KOO53843.1 - 0.18 11.3 0.0 2.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOO53845.1 - 2.6e-14 53.3 0.0 4e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOO53845.1 - 6e-08 32.8 0.0 1.8e-05 24.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 KOO53845.1 - 1.1e-07 32.0 0.0 0.0049 16.9 0.1 2.2 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 KOO53845.1 - 1.7e-05 24.5 0.0 0.0052 16.3 0.0 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOO53845.1 - 4.8e-05 22.9 0.0 0.0001 21.9 0.0 1.5 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_16 PF13191.6 KOO53845.1 - 0.00089 19.7 0.2 0.088 13.2 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 KOO53845.1 - 0.0068 16.6 0.0 0.024 14.9 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KOO53845.1 - 0.0096 15.4 0.0 0.015 14.8 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AIG1 PF04548.16 KOO53845.1 - 0.013 14.9 0.0 0.028 13.8 0.0 1.7 1 1 0 1 1 1 0 AIG1 family TniB PF05621.11 KOO53845.1 - 0.016 14.6 0.0 0.03 13.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 KOO53845.1 - 0.068 13.5 0.0 0.24 11.7 0.0 2.2 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KOO53845.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Guanylate_kin PF00625.21 KOO53845.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Guanylate kinase ABC_tran PF00005.27 KOO53845.1 - 0.12 12.9 0.0 0.14 12.7 0.0 1.5 1 1 0 1 1 1 0 ABC transporter Methyltransf_8 PF05148.15 KOO53845.1 - 0.13 12.1 0.0 0.37 10.6 0.0 1.8 1 1 1 2 2 2 0 Hypothetical methyltransferase Ribosomal_L11_N PF03946.14 KOO53846.1 - 8.1e-29 99.3 0.3 1.5e-28 98.4 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 KOO53846.1 - 2.1e-24 85.8 1.1 4.1e-24 84.9 1.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Methyltransf_24 PF13578.6 KOO53847.1 - 0.0062 17.5 0.0 0.012 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Phage_holin_4_2 PF04020.13 KOO53847.1 - 8.5 7.1 9.5 24 5.7 0.3 2.9 2 1 1 3 3 3 0 Mycobacterial 4 TMS phage holin, superfamily IV WD40 PF00400.32 KOO53848.1 - 1.1e-15 57.7 0.2 0.00034 21.3 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOO53848.1 - 0.047 12.6 0.4 11 4.8 0.0 2.9 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KOO53848.1 - 0.12 12.7 0.0 3.5 8.0 0.0 3.0 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Atg14 PF10186.9 KOO53849.1 - 0.00043 19.5 7.8 0.00043 19.5 7.8 3.7 2 1 2 4 4 4 1 Vacuolar sorting 38 and autophagy-related subunit 14 ATP-synt_B PF00430.18 KOO53849.1 - 0.009 16.1 17.6 0.009 16.1 17.6 7.2 3 3 4 7 7 7 1 ATP synthase B/B' CF(0) ELO PF01151.18 KOO53850.1 - 4.3e-37 128.0 11.5 1.1e-36 126.6 11.5 1.6 1 1 0 1 1 1 1 GNS1/SUR4 family Ank_2 PF12796.7 KOO53851.1 - 2.9e-15 56.6 0.1 7.3e-06 26.5 0.0 3.7 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO53851.1 - 8.9e-12 44.1 2.4 0.01 16.3 0.0 6.2 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 KOO53851.1 - 1.5e-10 41.1 4.3 3.1e-06 27.3 0.0 4.7 2 1 3 5 5 5 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOO53851.1 - 4.3e-09 36.7 0.4 0.011 16.3 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOO53851.1 - 1.2e-06 28.6 7.7 1.7 9.2 0.1 5.0 4 0 0 4 4 4 3 Ankyrin repeat UVR PF02151.19 KOO53851.1 - 2.3e-06 27.2 5.2 6.5e-06 25.7 5.2 1.9 1 0 0 1 1 1 1 UvrB/uvrC motif RhoGEF PF00621.20 KOO53851.1 - 2.9e-05 24.4 0.0 0.00017 21.9 0.0 2.1 1 1 0 1 1 1 1 RhoGEF domain PH PF00169.29 KOO53851.1 - 0.00073 20.0 0.0 0.0011 19.4 0.0 1.3 1 0 0 1 1 1 1 PH domain IQ PF00612.27 KOO53851.1 - 0.032 14.0 0.1 0.09 12.6 0.1 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif Chalcone_3 PF16036.5 KOO53851.1 - 0.21 11.7 0.8 18 5.4 0.0 2.5 2 0 0 2 2 2 0 Chalcone isomerase-like HSCB_C PF07743.13 KOO53851.1 - 0.29 11.7 2.6 1.9 9.0 0.5 3.2 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain ABC_tran_CTD PF16326.5 KOO53851.1 - 1.2 9.4 10.6 0.72 10.2 6.0 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain Utp13 PF08625.11 KOO53851.1 - 4.1 7.3 5.0 12 5.8 0.0 3.2 4 0 0 4 4 4 0 Utp13 specific WD40 associated domain Ribosomal_L6 PF00347.23 KOO53852.1 - 2.1e-12 47.5 0.6 2.1e-12 47.5 0.6 1.8 2 0 0 2 2 2 1 Ribosomal protein L6 FYVE PF01363.21 KOO53853.1 - 5.6e-27 93.7 31.5 1.8e-14 53.6 11.4 2.5 2 0 0 2 2 2 2 FYVE zinc finger FYVE_2 PF02318.16 KOO53853.1 - 0.0095 16.2 3.7 0.0095 16.2 3.7 2.5 2 0 0 2 2 2 2 FYVE-type zinc finger EF-hand_4 PF12763.7 KOO53854.1 - 3.8e-18 65.3 0.0 7.8e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SAICAR_synt PF01259.18 KOO53856.1 - 2.4e-89 299.3 0.0 3.2e-89 298.9 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase Dpy-30 PF05186.13 KOO53856.1 - 0.035 13.8 0.2 0.14 11.8 0.0 2.1 2 0 0 2 2 2 0 Dpy-30 motif UBA_4 PF14555.6 KOO53857.1 - 0.016 15.1 0.1 0.081 12.8 0.0 2.2 2 0 0 2 2 2 0 UBA-like domain Cupin_8 PF13621.6 KOO53858.1 - 3e-30 105.8 0.0 4.2e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOO53858.1 - 1.7e-09 37.6 0.1 2.8e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 KOO53858.1 - 0.006 17.0 0.0 0.017 15.5 0.0 1.8 1 1 0 1 1 1 1 JmjC domain, hydroxylase IcmF_C PF06744.12 KOO53860.1 - 0.028 14.1 0.1 0.045 13.4 0.1 1.3 1 0 0 1 1 1 0 Type VI secretion protein IcmF C-terminal Orai-1 PF07856.12 KOO53862.1 - 0.00059 19.6 8.3 0.0048 16.6 8.3 1.9 1 1 0 1 1 1 1 Mediator of CRAC channel activity DUF2244 PF10003.9 KOO53862.1 - 0.067 12.9 1.9 0.13 11.9 1.9 1.4 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) RseC_MucC PF04246.12 KOO53862.1 - 0.88 9.5 3.8 2.1 8.3 3.8 1.5 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC MgtE PF01769.16 KOO53862.1 - 4.7 7.6 7.8 88 3.5 7.8 2.1 1 1 0 1 1 1 0 Divalent cation transporter Ank_2 PF12796.7 KOO53863.1 - 7.4e-12 45.7 0.1 1.3e-11 44.9 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOO53863.1 - 1e-09 38.7 0.0 9e-07 29.3 0.0 3.0 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO53863.1 - 9.9e-08 32.1 0.5 0.0088 16.3 0.0 3.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOO53863.1 - 1.9e-07 30.8 0.1 1.3 9.8 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 KOO53863.1 - 4.1e-05 23.8 4.4 0.2 12.2 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat EccE PF11203.8 KOO53863.1 - 0.07 13.5 1.2 5.6 7.4 0.1 2.7 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE DUF2220 PF09983.9 KOO53864.1 - 0.17 11.2 0.0 0.17 11.2 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) Glyco_trans_1_2 PF13524.6 KOO53865.1 - 0.0011 19.3 0.0 0.0016 18.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 TIG PF01833.24 KOO53869.1 - 2.3e-05 24.4 0.0 0.16 12.1 0.0 3.3 2 0 0 2 2 2 2 IPT/TIG domain Methyltransf_24 PF13578.6 KOO53870.1 - 2.7e-08 34.8 0.1 5.8e-08 33.7 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain SNF2_N PF00176.23 KOO53871.1 - 2.7e-18 65.8 0.0 1.4e-13 50.4 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 KOO53871.1 - 2.9e-06 27.6 0.0 5.4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO53871.1 - 0.01 15.8 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit FHA PF00498.26 KOO53872.1 - 1.2e-15 57.6 0.0 1.6e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOO53872.1 - 2e-10 40.9 0.0 2.4e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain MU2_FHA PF18221.1 KOO53872.1 - 0.002 18.1 0.1 0.0027 17.7 0.1 1.2 1 0 0 1 1 1 1 Mutator 2 Fork head associated domain JmjC PF02373.22 KOO53873.1 - 4.6e-15 56.0 0.1 8.5e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 KOO53873.1 - 7e-14 52.2 0.0 1.6e-12 47.7 0.0 2.3 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 KOO53873.1 - 0.067 12.9 0.0 0.91 9.3 0.0 2.6 3 0 0 3 3 3 0 Cupin domain Cupin_4 PF08007.12 KOO53873.1 - 0.087 12.3 0.7 0.35 10.3 0.7 2.1 1 1 0 1 1 1 0 Cupin superfamily protein DnaJ PF00226.31 KOO53875.1 - 7.5e-19 67.6 0.2 1.3e-18 66.9 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.9 KOO53875.1 - 0.017 14.8 0.2 0.025 14.2 0.2 1.2 1 0 0 1 1 1 0 Transmembrane Fragile-X-F protein Beach PF02138.18 KOO53876.1 - 3.8e-57 193.8 0.0 5.6e-57 193.2 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain VPS9 PF02204.18 KOO53876.1 - 4.3e-09 36.5 0.0 9e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain IQ PF00612.27 KOO53876.1 - 0.0078 15.9 0.0 0.022 14.5 0.0 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif DHC_N2 PF08393.13 KOO53876.1 - 0.079 12.1 0.0 4.5 6.3 0.0 2.1 2 0 0 2 2 2 0 Dynein heavy chain, N-terminal region 2 GCP_N_terminal PF17681.1 KOO53876.1 - 0.082 12.5 0.0 0.31 10.6 0.0 1.9 2 1 1 3 3 3 0 Gamma tubulin complex component N-terminal tRNA-synt_1 PF00133.22 KOO53877.1 - 1.1e-107 360.8 0.0 8e-61 206.0 0.0 3.1 1 1 2 3 3 3 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KOO53877.1 - 5.8e-17 62.1 0.0 9.9e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA WHEP-TRS PF00458.20 KOO53877.1 - 1.1e-07 31.9 2.9 2.6e-07 30.7 2.9 1.7 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_1g PF09334.11 KOO53877.1 - 2e-05 23.5 0.0 0.4 9.4 0.0 3.2 3 0 0 3 3 3 3 tRNA synthetases class I (M) ABC1 PF03109.16 KOO53878.1 - 7.9e-24 84.1 0.0 1.4e-23 83.4 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOO53878.1 - 1.8e-06 28.0 0.2 1.8e-06 28.0 0.2 3.3 2 2 1 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 KOO53878.1 - 0.03 13.7 0.0 0.075 12.4 0.0 1.6 2 0 0 2 2 2 0 Protein kinase domain RNA_pol_Rpc4 PF05132.14 KOO53878.1 - 0.11 12.9 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Pkinase_Tyr PF07714.17 KOO53878.1 - 0.17 11.1 0.0 0.44 9.8 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase DUF1800 PF08811.11 KOO53880.1 - 1.1e-50 172.9 0.0 2.8e-27 95.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1800) DUF1501 PF07394.12 KOO53880.1 - 8e-40 137.1 0.1 1.7e-39 136.0 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1501) Acyl-CoA_dh_2 PF08028.11 KOO53881.1 - 0.63 10.3 3.6 0.52 10.6 1.4 2.0 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain PRKG1_interact PF15898.5 KOO53881.1 - 4.1 8.4 43.6 94 4.0 26.2 3.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain ARGLU PF15346.6 KOO53881.1 - 6 6.7 51.2 0.52 10.2 13.1 3.2 1 1 2 3 3 3 0 Arginine and glutamate-rich 1 Snf7 PF03357.21 KOO53882.1 - 1.8e-11 43.9 22.9 2.7e-11 43.4 22.7 1.4 1 1 0 1 1 1 1 Snf7 Nha1_C PF08619.10 KOO53882.1 - 0.069 12.3 3.9 0.076 12.2 3.9 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Ribosomal_S21 PF01165.20 KOO53882.1 - 0.077 12.7 0.1 0.2 11.4 0.1 1.7 1 0 0 1 1 1 0 Ribosomal protein S21 ArAE_1_C PF11728.8 KOO53882.1 - 0.88 9.5 7.5 0.14 12.1 2.5 1.8 1 1 1 2 2 2 0 Putative aromatic acid exporter C-terminal domain Methyltransf_25 PF13649.6 KOO53884.1 - 6.4e-08 33.2 0.6 0.00048 20.8 0.1 3.4 4 0 0 4 4 4 2 Methyltransferase domain Methyltransf_23 PF13489.6 KOO53884.1 - 3.8e-06 26.8 0.0 0.073 12.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain PCMT PF01135.19 KOO53884.1 - 3.1e-05 23.8 0.4 0.029 14.1 0.1 2.2 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 KOO53884.1 - 9.3e-05 23.1 0.1 0.034 14.9 0.1 2.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOO53884.1 - 0.00012 21.9 0.0 0.018 14.9 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOO53884.1 - 0.00052 20.6 0.6 1.2 9.9 0.1 3.6 4 0 0 4 4 4 2 Methyltransferase domain Methyltransf_24 PF13578.6 KOO53884.1 - 0.0026 18.7 0.3 0.89 10.6 0.1 2.5 2 0 0 2 2 2 2 Methyltransferase domain TAT_signal PF10518.9 KOO53885.1 - 0.31 11.0 0.3 0.31 11.0 0.3 2.3 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence DEAD PF00270.29 KOO53886.1 - 8e-47 159.3 0.0 1.2e-46 158.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOO53886.1 - 6.9e-30 103.6 0.0 1.7e-29 102.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOO53886.1 - 0.0027 17.7 0.0 0.0053 16.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOO53886.1 - 0.007 15.6 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 KOO53886.1 - 0.073 12.4 0.8 0.42 9.9 0.0 2.3 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 KOO53886.1 - 0.13 12.5 0.4 1 9.6 0.1 2.6 2 1 0 2 2 2 0 AAA domain Porin_3 PF01459.22 KOO53888.1 - 8.3e-30 104.2 1.3 1.1e-29 103.8 1.3 1.1 1 0 0 1 1 1 1 Eukaryotic porin LRR_6 PF13516.6 KOO53889.1 - 1e-18 65.7 7.7 0.0047 16.9 0.0 7.2 6 1 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.7 KOO53889.1 - 0.021 15.2 0.7 6.7 7.3 0.0 4.2 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) HOASN PF14515.6 KOO53889.1 - 0.036 14.4 9.3 4.5 7.7 0.1 4.5 1 1 3 4 4 4 0 Haem-oxygenase-associated N-terminal helices CbiG_N PF11760.8 KOO53889.1 - 0.041 13.9 7.7 40 4.3 0.1 4.6 4 1 0 4 4 4 0 Cobalamin synthesis G N-terminal EIF_2_alpha PF07541.12 KOO53889.1 - 0.2 11.8 0.1 1.7 8.8 0.1 2.1 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit SpoU_sub_bind PF08032.12 KOO53889.1 - 0.27 11.6 1.4 9.5 6.6 0.1 3.3 2 1 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding FAM25 PF15825.5 KOO53889.1 - 1.9 8.9 17.2 25 5.3 0.4 5.2 3 1 2 5 5 5 0 FAM25 family DndB PF14072.6 KOO53890.1 - 0.06 12.5 0.0 0.18 11.0 0.0 1.7 2 0 0 2 2 2 0 DNA-sulfur modification-associated EF-hand_1 PF00036.32 KOO53891.1 - 3.2e-14 51.3 0.9 3.1e-06 26.3 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOO53891.1 - 2.3e-12 45.8 2.3 6.7e-05 22.5 0.1 3.1 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOO53891.1 - 3.1e-09 37.1 2.4 2.5e-06 27.8 0.5 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO53891.1 - 3.4e-09 36.4 0.0 0.0028 17.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOO53891.1 - 4.6e-08 32.2 0.6 0.00082 18.8 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 KOO53891.1 - 0.057 13.3 0.5 0.37 10.7 0.1 2.1 2 0 0 2 2 2 0 EF hand Ribosomal_L12_N PF16320.5 KOO53891.1 - 0.13 12.0 0.2 0.13 12.0 0.2 2.1 2 1 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain EF-hand_6 PF13405.6 KOO53893.1 - 6.2e-09 35.1 0.1 0.002 17.9 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOO53893.1 - 2.7e-07 29.7 0.0 0.02 14.4 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KOO53893.1 - 4.1e-07 29.2 0.0 0.0059 16.0 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOO53893.1 - 1.6e-05 25.2 0.0 0.16 12.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOO53893.1 - 0.00025 20.8 0.0 0.55 10.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair HD PF01966.22 KOO53894.1 - 5.1e-13 49.3 0.0 1.2e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 HD domain zinc_ribbon_2 PF13240.6 KOO53894.1 - 0.00026 20.6 2.6 0.00057 19.5 2.6 1.5 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 KOO53894.1 - 0.00079 19.4 1.1 0.0018 18.3 1.1 1.6 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 KOO53894.1 - 0.033 14.9 0.8 0.072 13.9 0.8 1.5 1 0 0 1 1 1 0 zinc-ribbon family PHF5 PF03660.14 KOO53894.1 - 0.053 13.7 0.4 0.1 12.8 0.4 1.4 1 0 0 1 1 1 0 PHF5-like protein zf-ribbon_3 PF13248.6 KOO53894.1 - 0.094 12.2 1.5 0.22 11.0 1.5 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Arm PF00514.23 KOO53895.1 - 8.4e-06 25.6 4.5 0.0099 15.9 0.0 5.1 4 1 0 4 4 4 2 Armadillo/beta-catenin-like repeat EF-hand_7 PF13499.6 KOO53896.1 - 7.8e-15 55.1 3.3 0.00026 21.4 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 KOO53896.1 - 8.2e-14 50.0 2.2 1.1e-07 30.9 0.2 4.2 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KOO53896.1 - 6.4e-12 44.4 6.3 0.0017 18.2 0.1 5.1 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KOO53896.1 - 4.5e-10 38.5 7.6 7.5e-05 22.0 0.3 3.3 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 KOO53896.1 - 1.9e-08 34.6 0.4 0.00015 22.1 0.0 3.5 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KOO53896.1 - 2.1e-08 33.9 1.2 4.6e-06 26.4 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 KOO53896.1 - 0.00078 19.4 0.9 0.0034 17.3 0.1 2.3 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand bZIP_1 PF00170.21 KOO53896.1 - 0.0095 16.0 1.4 0.027 14.6 1.4 1.7 1 0 0 1 1 1 1 bZIP transcription factor EF-hand_10 PF14788.6 KOO53896.1 - 0.18 11.7 2.3 2.4 8.1 0.1 3.2 4 0 0 4 4 4 0 EF hand IQ PF00612.27 KOO53896.1 - 0.36 10.8 3.4 1.6 8.7 3.4 2.2 1 0 0 1 1 1 0 IQ calmodulin-binding motif Hydrolase_4 PF12146.8 KOO53897.1 - 5.7e-10 38.9 0.0 9.9e-10 38.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF229 PF02995.17 KOO53898.1 - 2.1e-33 115.7 0.0 2.6e-33 115.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF229) LigT_PEase PF02834.16 KOO53898.1 - 0.06 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 LigT like Phosphoesterase LIN52 PF10044.9 KOO53899.1 - 0.076 13.7 1.0 0.16 12.7 0.0 2.1 2 1 0 2 2 2 0 Retinal tissue protein YL1 PF05764.13 KOO53899.1 - 0.088 12.9 15.5 0.16 12.0 15.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein MIase PF02426.16 KOO53899.1 - 0.14 12.3 0.9 0.55 10.4 0.9 2.0 1 0 0 1 1 1 0 Muconolactone delta-isomerase SpoIIIAH PF12685.7 KOO53899.1 - 0.3 10.9 8.9 0.54 10.0 8.9 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein FAM176 PF14851.6 KOO53899.1 - 1.2 8.8 7.6 3.3 7.4 7.2 1.9 2 0 0 2 2 2 0 FAM176 family CDC45 PF02724.14 KOO53899.1 - 1.3 7.3 10.2 1.7 6.9 10.2 1.2 1 0 0 1 1 1 0 CDC45-like protein LRR_5 PF13306.6 KOO53900.1 - 3.4e-93 308.3 0.0 3e-38 130.7 0.0 3.0 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO53900.1 - 1.7e-17 62.9 0.0 0.00063 19.5 0.0 6.4 2 2 4 6 6 6 4 Leucine rich repeat He_PIG PF05345.12 KOO53900.1 - 0.0064 16.7 9.4 1.4e+02 2.8 0.0 7.4 8 0 0 8 8 8 0 Putative Ig domain LRR_4 PF12799.7 KOO53900.1 - 0.014 15.8 0.0 14 6.2 0.1 5.0 5 2 3 8 8 8 0 Leucine Rich repeats (2 copies) Forkhead_N PF08430.12 KOO53900.1 - 0.24 12.0 17.7 3.3 8.3 6.1 3.2 1 1 1 2 2 2 0 Forkhead N-terminal region ZF-HD_dimer PF04770.12 KOO53900.1 - 2.6 8.4 8.8 25 5.3 0.0 4.9 6 1 0 6 6 6 0 ZF-HD protein dimerisation region Biotin_carb_N PF00289.22 KOO53901.1 - 2.3e-22 79.6 0.1 3.2e-22 79.2 0.1 1.2 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain BSD PF03909.17 KOO53902.1 - 1.6e-15 56.9 0.0 1.5e-06 28.1 0.0 2.4 2 0 0 2 2 2 2 BSD domain LTXXQ PF07813.12 KOO53902.1 - 0.2 12.4 2.3 24 5.7 0.0 2.9 3 0 0 3 3 3 0 LTXXQ motif family protein YopE PF03545.13 KOO53903.1 - 0.088 13.0 0.1 0.65 10.2 0.0 2.3 2 1 0 2 2 2 0 Yersinia virulence determinant (YopE) Tyr-DNA_phospho PF06087.12 KOO53904.1 - 5.6e-26 91.4 0.0 7.6e-11 41.5 0.0 3.0 1 1 2 3 3 3 3 Tyrosyl-DNA phosphodiesterase LRR_5 PF13306.6 KOO53905.1 - 5.5e-146 479.0 0.1 4.2e-39 133.4 0.0 3.5 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 KOO53905.1 - 6.8e-26 89.8 0.0 0.016 14.9 0.0 9.0 2 1 9 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 KOO53905.1 - 0.0023 18.3 7.4 2.4e+02 2.3 0.1 8.7 7 3 2 10 10 10 0 Leucine Rich repeats (2 copies) CBFB_NFYA PF02045.15 KOO53906.1 - 2.3e-16 60.1 7.8 3.2e-16 59.7 7.8 1.2 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Pribosyltran PF00156.27 KOO53908.1 - 5.6e-21 74.7 0.0 7e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 KOO53908.1 - 0.056 12.9 0.0 0.085 12.3 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase UPRTase PF14681.6 KOO53908.1 - 0.079 12.4 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase RPAP3_C PF13877.6 KOO53909.1 - 4.4 7.9 11.5 16 6.1 1.7 5.0 2 2 1 3 3 3 0 Potential Monad-binding region of RPAP3 Ank_2 PF12796.7 KOO53911.1 - 1.6e-17 63.8 1.3 1.8e-07 31.6 0.0 2.4 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOO53911.1 - 1.1e-13 49.9 1.5 0.00036 20.7 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KOO53911.1 - 2.5e-13 49.8 6.0 0.0021 18.5 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KOO53911.1 - 2.3e-10 40.8 0.3 3.5e-05 24.3 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOO53911.1 - 1.1e-09 38.4 3.5 0.00015 22.0 0.1 3.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) AflR PF08493.10 KOO53912.1 - 0.29 10.6 5.5 0.48 9.8 5.5 1.3 1 0 0 1 1 1 0 Aflatoxin regulatory protein SAC3_GANP PF03399.16 KOO53914.1 - 0.051 13.0 0.0 0.087 12.2 0.0 1.2 1 0 0 1 1 1 0 SAC3/GANP family Biotin_lipoyl PF00364.22 KOO53915.1 - 5.9e-14 51.6 0.0 7e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 Biotin-requiring enzyme DUF2118 PF09891.9 KOO53915.1 - 0.14 12.1 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) DUF1488 PF07369.11 KOO53915.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) Amino_oxidase PF01593.24 KOO53916.1 - 3e-56 191.6 0.4 9.7e-56 189.9 0.4 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOO53916.1 - 4.2e-13 49.3 0.0 1.1e-12 48.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOO53916.1 - 3.2e-07 29.8 0.4 5e-07 29.2 0.4 1.2 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 KOO53916.1 - 3.2e-07 29.8 2.4 3.2e-07 29.8 2.4 2.4 3 0 0 3 3 2 1 FAD binding domain HI0933_like PF03486.14 KOO53916.1 - 5.2e-07 28.7 0.4 8.7e-07 28.0 0.4 1.3 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 KOO53916.1 - 6.5e-07 29.3 2.6 1.3e-06 28.2 2.6 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KOO53916.1 - 1e-05 24.8 2.1 0.00032 19.9 0.6 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 KOO53916.1 - 1.1e-05 25.9 0.1 2.9e-05 24.5 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOO53916.1 - 1.3e-05 24.6 0.9 1.3e-05 24.6 0.9 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 KOO53916.1 - 3.1e-05 23.4 0.1 0.00027 20.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KOO53916.1 - 0.00012 21.6 2.2 0.00019 21.0 2.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 KOO53916.1 - 0.0015 18.5 0.7 0.019 15.0 0.1 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding FMO-like PF00743.19 KOO53916.1 - 0.0022 16.5 0.0 0.003 16.0 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like GIDA PF01134.22 KOO53916.1 - 0.0026 16.9 0.5 0.0043 16.2 0.5 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 KOO53916.1 - 0.0032 16.8 0.1 0.0053 16.0 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 KOO53916.1 - 0.027 14.3 0.3 0.047 13.6 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 KOO53916.1 - 0.044 13.3 0.1 0.071 12.7 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 KOO53916.1 - 0.12 11.7 0.9 0.19 11.0 0.9 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 KOO53916.1 - 0.17 12.1 0.1 0.48 10.7 0.1 1.8 1 0 0 1 1 1 0 TrkA-N domain IQ PF00612.27 KOO53917.1 - 0.079 12.8 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Haptophyta/Chrysochromulina_sp._CCMP291-Ctobinv2/GCA_001275005.1_Ctobinv2_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Haptophyta/Chrysochromulina_sp._CCMP291-Ctobinv2/GCA_001275005.1_Ctobinv2_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Haptophyta/Chrysochromulina_sp._CCMP291-Ctobinv2/GCA_001275005.1_Ctobinv2_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Haptophyta/Chrysochromulina_sp._CCMP291-Ctobinv2/GCA_001275005.1_Ctobinv2_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 09:20:52 2019 # [ok]