# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Aldo_ket_red PF00248.21 EFE37181.1 - 4e-41 141.1 0.0 8.7e-40 136.7 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family UPF0061 PF02696.14 EFE37183.1 - 1.3e-98 330.8 0.0 1.4e-81 274.6 0.0 2.0 1 1 1 2 2 2 2 Uncharacterized ACR, YdiU/UPF0061 family DUF3422 PF11902.8 EFE37185.1 - 0.19 10.8 0.1 0.25 10.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) DUF3678 PF12435.8 EFE37185.1 - 0.32 10.4 6.9 2.4 7.6 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) zf-C2H2 PF00096.26 EFE37186.1 - 5e-10 39.3 11.4 1.5e-05 25.2 4.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE37186.1 - 7.6e-06 26.1 27.8 2.6e-05 24.4 0.4 4.0 4 0 0 4 4 3 3 Zinc-finger double domain zf-met PF12874.7 EFE37186.1 - 9.5e-06 25.8 4.4 1.9e-05 24.9 1.2 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EFE37186.1 - 8.2e-05 22.5 8.7 0.00014 21.7 2.1 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EFE37186.1 - 0.00023 21.7 10.3 0.00064 20.3 2.9 3.2 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFE37186.1 - 0.00026 21.2 6.5 0.00072 19.8 2.0 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 EFE37186.1 - 0.03 14.2 4.3 3.2 7.8 0.4 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DarA_C PF18789.1 EFE37186.1 - 0.1 12.9 0.8 15 6.0 0.0 2.7 2 0 0 2 2 2 0 Defence against restriction A C-terminal Actin_micro PF17003.5 EFE37186.1 - 0.24 10.6 0.2 0.36 9.9 0.2 1.2 1 0 0 1 1 1 0 Putative actin-like family Hydin_ADK PF17213.3 EFE37186.1 - 0.37 11.0 6.0 20 5.4 5.5 2.4 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain PAT1 PF09770.9 EFE37186.1 - 0.59 8.3 12.6 0.8 7.9 12.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-C2H2_11 PF16622.5 EFE37186.1 - 0.9 9.4 7.3 7.8 6.4 0.8 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type Spt20 PF12090.8 EFE37186.1 - 1.6 8.3 18.9 2.7 7.5 18.9 1.3 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 EFE37186.1 - 2 7.1 5.3 2.9 6.6 5.3 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 EFE37186.1 - 2 8.4 5.0 1.6 8.7 1.8 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Suf PF05843.14 EFE37186.1 - 5.9 6.8 10.0 2.7 7.9 7.3 1.8 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DsbC PF11412.8 EFE37187.1 - 0.0033 17.4 0.0 0.0033 17.4 0.0 1.2 1 0 0 1 1 1 1 Disulphide bond corrector protein DsbC Adeno_PV PF03910.13 EFE37187.1 - 0.045 12.5 1.5 0.047 12.4 1.5 1.0 1 0 0 1 1 1 0 Adenovirus minor core protein PV GST_N_3 PF13417.6 EFE37189.1 - 0.0013 19.1 0.0 0.0029 18.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFE37189.1 - 0.0039 17.4 0.0 0.049 13.9 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE37189.1 - 0.013 15.5 0.4 2.7 8.1 0.0 2.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFE37189.1 - 0.026 15.3 0.0 0.053 14.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain SURF2 PF05477.11 EFE37190.1 - 0.24 11.1 11.1 0.33 10.6 11.1 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Cwf_Cwc_15 PF04889.12 EFE37190.1 - 3.3 7.4 28.9 6.8 6.4 28.9 1.4 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 EFE37190.1 - 6.1 4.9 26.4 6.7 4.8 26.4 1.0 1 0 0 1 1 1 0 Nop14-like family Ins_P5_2-kin PF06090.12 EFE37191.1 - 5.5e-45 154.2 0.0 4.8e-44 151.1 0.0 1.9 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DUF4444 PF14563.6 EFE37191.1 - 0.053 13.2 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4444) Sec15 PF04091.12 EFE37192.1 - 1.6e-103 346.5 0.4 2.9e-81 273.3 0.1 3.0 1 1 1 2 2 2 2 Exocyst complex subunit Sec15-like COG2 PF06148.11 EFE37192.1 - 0.0013 18.8 4.8 0.0013 18.8 4.8 2.4 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Sec8_exocyst PF04048.14 EFE37192.1 - 0.0018 18.2 3.2 0.0018 18.2 3.2 2.2 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain PMEI PF04043.15 EFE37192.1 - 0.049 14.0 0.6 0.11 12.8 0.6 1.6 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor Sec5 PF15469.6 EFE37192.1 - 0.11 12.3 9.4 0.12 12.2 3.6 3.2 3 0 0 3 3 3 0 Exocyst complex component Sec5 COG5 PF10392.9 EFE37192.1 - 0.37 11.0 7.0 0.37 11.0 4.7 2.3 2 0 0 2 2 2 0 Golgi transport complex subunit 5 CBFD_NFYB_HMF PF00808.23 EFE37193.1 - 4e-19 68.7 0.4 7e-19 67.9 0.4 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFE37193.1 - 2.5e-16 60.2 0.2 3.8e-16 59.7 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EFE37193.1 - 0.034 14.5 0.0 0.053 13.8 0.0 1.4 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Totivirus_coat PF05518.11 EFE37193.1 - 0.23 9.5 5.5 0.28 9.2 5.5 1.1 1 0 0 1 1 1 0 Totivirus coat protein Tubulin_C PF03953.17 EFE37194.1 - 1.4e-48 164.2 0.1 1.9e-48 163.8 0.1 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain EF-hand_4 PF12763.7 EFE37195.1 - 8.7e-20 70.6 0.0 1.3e-15 57.2 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 EFE37195.1 - 1e-05 25.8 0.0 3.3e-05 24.2 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EFE37195.1 - 3e-05 23.2 1.1 0.018 14.5 0.0 4.1 4 0 0 4 4 4 1 EF hand DUF812 PF05667.11 EFE37195.1 - 0.00047 19.2 12.8 0.00047 19.2 12.8 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF812) UBA PF00627.31 EFE37195.1 - 0.00065 19.5 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain BicD PF09730.9 EFE37195.1 - 0.0074 14.8 27.0 0.031 12.7 25.9 1.9 1 1 0 1 1 1 1 Microtubule-associated protein Bicaudal-D EF-hand_8 PF13833.6 EFE37195.1 - 0.0087 15.9 0.3 0.077 12.9 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair GAS PF13851.6 EFE37195.1 - 0.012 15.0 32.4 0.084 12.2 18.3 2.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding EF-hand_6 PF13405.6 EFE37195.1 - 0.019 14.9 0.9 7.8 6.7 0.0 3.8 3 0 0 3 3 3 0 EF-hand domain DUF3584 PF12128.8 EFE37195.1 - 0.21 9.1 29.1 0.3 8.6 29.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3450 PF11932.8 EFE37195.1 - 0.3 10.3 35.2 0.049 12.9 13.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) MbeD_MobD PF04899.12 EFE37195.1 - 0.44 10.7 17.7 2.1 8.5 1.0 4.3 3 1 1 4 4 4 0 MbeD/MobD like TMF_TATA_bd PF12325.8 EFE37195.1 - 0.45 10.8 30.4 0.054 13.7 4.9 3.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding FPP PF05911.11 EFE37195.1 - 0.62 8.2 26.5 0.92 7.6 26.5 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil IFT57 PF10498.9 EFE37195.1 - 1.1 8.2 21.7 6.4 5.6 21.5 2.0 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 CALCOCO1 PF07888.11 EFE37195.1 - 1.2 8.0 27.7 1.8 7.4 27.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.11 EFE37195.1 - 1.6 7.5 33.7 0.55 9.1 10.6 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.10 EFE37195.1 - 2.8 8.1 22.1 0.02 15.1 8.4 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ATG16 PF08614.11 EFE37195.1 - 3.5 7.8 39.1 4.2 7.5 15.6 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Exonuc_VII_L PF02601.15 EFE37195.1 - 5.4 6.5 17.6 11 5.5 17.6 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cep57_MT_bd PF06657.13 EFE37195.1 - 6.4 7.3 14.6 0.12 12.8 4.1 3.0 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 CENP-F_leu_zip PF10473.9 EFE37195.1 - 6.8 6.7 32.2 0.9 9.6 12.1 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V_ATPase_I PF01496.19 EFE37195.1 - 10 3.9 14.3 20 3.0 14.3 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MARVEL PF01284.23 EFE37196.1 - 3.5e-14 53.0 15.9 1.1e-13 51.5 15.9 1.6 1 1 0 1 1 1 1 Membrane-associating domain Cys_Met_Meta_PP PF01053.20 EFE37197.1 - 2.2e-124 414.9 0.0 2.7e-124 414.6 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EFE37197.1 - 7.7e-11 41.9 0.1 1.5e-10 41.0 0.1 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EFE37197.1 - 4.5e-05 22.8 0.0 7.4e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EFE37197.1 - 0.00015 21.2 0.0 0.00022 20.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EFE37197.1 - 0.012 14.6 0.1 0.033 13.2 0.1 1.7 1 1 0 1 1 1 0 Aminotransferase class-V Asparaginase_C PF17763.1 EFE37197.1 - 0.11 12.7 0.1 0.31 11.3 0.0 1.8 2 0 0 2 2 2 0 Glutaminase/Asparaginase C-terminal domain AMP-binding PF00501.28 EFE37198.1 - 4.4e-80 269.4 0.0 5.4e-80 269.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF2012 PF09430.10 EFE37199.1 - 2.2e-24 85.9 0.0 3.1e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) SOP4 PF17081.5 EFE37199.1 - 0.053 13.0 0.1 0.14 11.7 0.1 1.7 2 0 0 2 2 2 0 Suppressor of PMA 1-7 protein LCCL PF03815.19 EFE37200.1 - 2.9e-18 65.8 0.1 4.8e-18 65.1 0.1 1.3 1 0 0 1 1 1 1 LCCL domain DUF3328 PF11807.8 EFE37201.1 - 0.034 13.9 7.9 0.55 10.0 7.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EFE37203.1 - 5.9e-05 22.9 0.0 6.1e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Ank_2 PF12796.7 EFE37204.1 - 3.8e-34 117.1 3.7 3.6e-21 75.5 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE37204.1 - 7e-31 106.2 1.0 7e-15 55.2 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE37204.1 - 2.4e-20 72.3 0.7 7.3e-07 29.3 0.0 3.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFE37204.1 - 2e-18 65.9 0.6 3.6e-05 24.0 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EFE37204.1 - 6.8e-17 59.8 0.0 1.5e-05 24.9 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat bZIP_Maf PF03131.17 EFE37204.1 - 0.046 14.2 6.3 0.078 13.5 6.3 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor VWA_3_C PF18571.1 EFE37204.1 - 0.048 13.5 0.3 3.4 7.6 0.1 2.4 2 0 0 2 2 2 0 von Willebrand factor type A C-terminal domain bZIP_1 PF00170.21 EFE37204.1 - 0.089 12.9 10.3 0.15 12.2 10.3 1.3 1 0 0 1 1 1 0 bZIP transcription factor PTR2 PF00854.21 EFE37205.1 - 2.4e-79 267.0 7.5 3.3e-79 266.6 7.5 1.2 1 0 0 1 1 1 1 POT family Methyltransf_32 PF13679.6 EFE37206.1 - 3.5e-20 72.6 2.7 1.6e-19 70.4 2.7 2.0 1 1 0 1 1 1 1 Methyltransferase domain Syntaxin-6_N PF09177.11 EFE37207.1 - 2.6e-19 69.6 2.8 4.5e-19 68.8 0.1 2.5 3 0 0 3 3 3 1 Syntaxin 6, N-terminal APG17 PF04108.12 EFE37207.1 - 0.005 16.0 3.3 0.11 11.6 0.4 2.2 2 0 0 2 2 2 2 Autophagy protein Apg17 DUF3618 PF12277.8 EFE37207.1 - 0.0071 16.6 7.2 1.1 9.5 0.1 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF3618) DUF4795 PF16043.5 EFE37207.1 - 0.026 14.1 0.2 1.1 8.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) HMMR_N PF15905.5 EFE37207.1 - 0.033 13.7 0.1 0.033 13.7 0.1 1.9 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF4726 PF15855.5 EFE37207.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4726) Phage_int_SAM_2 PF12834.7 EFE37207.1 - 0.13 13.0 0.1 0.4 11.4 0.1 1.8 1 0 0 1 1 1 0 Phage integrase, N-terminal SPX PF03105.19 EFE37207.1 - 0.13 12.2 0.7 0.15 12.0 0.7 1.1 1 0 0 1 1 1 0 SPX domain Vps51 PF08700.11 EFE37207.1 - 0.2 11.7 3.6 12 6.1 0.0 3.2 3 1 0 3 3 3 0 Vps51/Vps67 Laminin_II PF06009.12 EFE37207.1 - 0.3 11.1 1.4 6.6 6.8 0.1 2.4 2 1 0 2 2 2 0 Laminin Domain II Cnn_1N PF07989.11 EFE37207.1 - 0.4 10.9 7.5 7.6 6.8 1.1 3.3 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 DUF883 PF05957.13 EFE37207.1 - 0.53 10.9 4.4 28 5.4 0.0 3.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) GCIP PF13324.6 EFE37207.1 - 0.6 9.7 4.2 0.57 9.8 2.2 1.9 2 1 0 2 2 2 0 Grap2 and cyclin-D-interacting YtxH PF12732.7 EFE37207.1 - 0.83 10.2 3.1 3.2 8.3 0.5 2.5 2 1 0 2 2 2 0 YtxH-like protein NPV_P10 PF05531.12 EFE37207.1 - 2.2 8.8 5.3 9 6.8 0.8 2.9 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein NAP PF00956.18 EFE37208.1 - 1.6e-19 70.1 7.0 1.6e-19 70.1 7.0 2.5 2 1 1 3 3 3 2 Nucleosome assembly protein (NAP) NmrA PF05368.13 EFE37209.1 - 5.6e-60 202.8 0.0 7.1e-60 202.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFE37209.1 - 6.9e-07 29.3 0.0 1.1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding DUF1876 PF08962.11 EFE37209.1 - 0.17 11.9 1.5 0.21 11.6 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1876) Asparaginase PF00710.20 EFE37210.1 - 8.5e-57 191.8 0.0 1.3e-56 191.2 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EFE37210.1 - 7.2e-30 103.5 0.2 3.1e-29 101.5 0.3 1.9 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 EFE37210.1 - 3.5e-15 56.4 0.6 1.3e-09 38.5 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFE37210.1 - 4.4e-10 39.6 3.4 5.6e-06 26.6 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFE37210.1 - 3.1e-08 33.3 1.1 0.0017 18.7 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFE37210.1 - 2.1e-07 31.1 0.0 8.1e-07 29.2 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFE37210.1 - 1.9e-06 28.3 0.1 0.00061 20.3 0.1 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) MTTB PF06253.11 EFE37210.1 - 0.018 13.0 0.1 0.029 12.4 0.1 1.2 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) Peptidase_S8 PF00082.22 EFE37211.1 - 3.5e-42 144.7 0.4 5.6e-42 144.0 0.4 1.3 1 0 0 1 1 1 1 Subtilase family MotA_activ PF09114.10 EFE37211.1 - 0.16 12.1 0.1 0.48 10.6 0.1 1.8 1 0 0 1 1 1 0 Transcription factor MotA, activation domain APH PF01636.23 EFE37213.1 - 1.1e-16 61.5 0.0 2.1e-15 57.3 0.0 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE37213.1 - 0.0015 17.5 0.0 1.1 8.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) DarA_N PF18788.1 EFE37213.1 - 0.14 12.2 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 Defence against restriction A N-terminal APH PF01636.23 EFE37215.1 - 3.5e-11 43.5 0.0 7.4e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE37215.1 - 3.5e-05 23.5 0.0 5.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EFE37215.1 - 0.00034 20.1 0.1 0.4 10.0 0.0 2.3 2 1 0 2 2 2 2 Protein kinase domain Fructosamin_kin PF03881.14 EFE37215.1 - 0.055 12.7 0.0 9.6 5.3 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase CBM_19 PF03427.13 EFE37215.1 - 0.073 13.1 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) AA_permease_2 PF13520.6 EFE37216.1 - 8.3e-70 235.7 38.8 1.1e-69 235.4 38.8 1.2 1 0 0 1 1 1 1 Amino acid permease DAP10 PF07213.11 EFE37216.1 - 0.03 14.3 1.6 0.72 9.8 0.4 2.6 2 0 0 2 2 2 0 DAP10 membrane protein adh_short PF00106.25 EFE37217.1 - 1.6e-34 119.1 0.0 2.1e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE37217.1 - 2.2e-22 79.8 0.0 2.7e-22 79.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE37217.1 - 0.00016 21.6 0.0 0.00022 21.2 0.0 1.2 1 0 0 1 1 1 1 KR domain TrkA_N PF02254.18 EFE37217.1 - 0.0015 18.8 0.0 0.0028 17.9 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_10 PF13460.6 EFE37217.1 - 0.052 13.4 0.1 0.092 12.6 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H-binding CBFD_NFYB_HMF PF00808.23 EFE37218.1 - 5.3e-18 65.1 0.2 5.3e-18 65.1 0.2 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFE37218.1 - 0.00023 21.5 0.3 0.00061 20.1 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EFE37218.1 - 0.027 14.6 0.0 0.039 14.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFE37218.1 - 0.059 13.4 0.0 0.091 12.8 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated YolD PF08863.10 EFE37218.1 - 0.17 12.0 4.2 0.11 12.5 2.3 1.6 2 0 0 2 2 2 0 YolD-like protein Actin PF00022.19 EFE37219.1 - 1e-21 77.0 0.0 4.1e-18 65.2 0.0 3.0 3 0 0 3 3 3 3 Actin Bystin PF05291.11 EFE37220.1 - 4.1e-130 433.3 0.0 5.4e-130 432.9 0.0 1.1 1 0 0 1 1 1 1 Bystin Amidase PF01425.21 EFE37222.1 - 1e-103 347.8 3.5 5.1e-58 197.1 5.0 2.2 2 0 0 2 2 2 2 Amidase DUF3347 PF11827.8 EFE37223.1 - 9.1 6.4 8.7 14 5.8 4.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) BTRD1 PF17660.1 EFE37224.1 - 7.5e-68 224.2 2.7 1.7e-13 50.1 0.2 5.0 5 0 0 5 5 5 5 Bacterial tandem repeat domain 1 PaaB PF06243.11 EFE37224.1 - 0.042 14.1 1.7 16 5.8 0.0 3.3 3 1 1 4 4 4 0 Phenylacetic acid degradation B bZIP_2 PF07716.15 EFE37225.1 - 2.3e-08 34.0 14.2 2.3e-08 34.0 14.2 2.6 2 1 1 3 3 2 2 Basic region leucine zipper bZIP_1 PF00170.21 EFE37225.1 - 1e-06 28.7 17.9 5.5e-06 26.4 17.9 2.1 1 1 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EFE37225.1 - 0.004 17.6 12.0 0.0078 16.7 12.0 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor SAP130_C PF16014.5 EFE37225.1 - 0.011 14.9 6.2 0.021 13.9 6.2 1.5 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus FPP PF05911.11 EFE37225.1 - 0.015 13.5 6.3 0.022 13.0 6.3 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Striatin PF08232.12 EFE37225.1 - 0.017 15.7 6.9 0.017 15.7 6.9 1.8 1 1 1 2 2 2 0 Striatin family DLIC PF05783.11 EFE37225.1 - 0.044 12.6 4.6 0.062 12.1 4.6 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) APG6_N PF17675.1 EFE37225.1 - 0.17 12.4 13.1 0.34 11.4 13.1 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF3450 PF11932.8 EFE37225.1 - 0.51 9.6 7.1 0.81 8.9 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Mucin PF01456.17 EFE37225.1 - 0.62 10.1 17.7 1.2 9.1 17.7 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein ATF7IP_BD PF16788.5 EFE37225.1 - 1.1 9.4 11.2 1.7 8.7 11.2 1.3 1 0 0 1 1 1 0 ATF-interacting protein binding domain KIAA1430 PF13879.6 EFE37225.1 - 2.1 9.1 13.3 1.5 9.6 8.9 2.6 2 1 1 3 3 3 0 KIAA1430 homologue CENP-H PF05837.12 EFE37225.1 - 6.8 7.2 10.4 0.56 10.6 4.0 2.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) APH PF01636.23 EFE37226.1 - 3.2e-08 33.8 0.0 1.2e-07 31.9 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE37226.1 - 0.00094 18.1 0.1 0.029 13.3 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.14 EFE37226.1 - 0.02 14.1 0.0 0.53 9.4 0.0 2.2 2 0 0 2 2 2 0 Fructosamine kinase ADH_zinc_N PF00107.26 EFE37227.1 - 6.2e-14 52.1 0.0 1.3e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE37227.1 - 0.03 14.2 0.0 0.074 12.9 0.0 1.6 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EFE37227.1 - 0.14 11.6 0.1 0.23 10.9 0.1 1.2 1 0 0 1 1 1 0 short chain dehydrogenase Metallophos PF00149.28 EFE37228.1 - 2.5e-09 38.0 0.0 7.4e-09 36.4 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EFE37228.1 - 0.00086 19.5 0.0 0.0017 18.6 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Transket_pyr PF02779.24 EFE37229.1 - 2.2e-47 161.0 0.0 4.1e-47 160.1 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFE37229.1 - 4.7e-35 120.2 0.1 1.2e-34 118.9 0.1 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain SLAIN PF15301.6 EFE37229.1 - 0.038 13.2 2.1 0.057 12.7 2.1 1.2 1 0 0 1 1 1 0 SLAIN motif-containing family Glyco_hydro_43 PF04616.14 EFE37230.1 - 3.3e-50 171.0 4.6 1.3e-49 169.1 4.6 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 zf-C2H2 PF00096.26 EFE37231.1 - 0.0033 17.8 1.2 0.0069 16.8 1.2 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.7 EFE37231.1 - 0.006 16.9 0.3 0.01 16.2 0.3 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFE37231.1 - 0.015 15.6 2.3 0.024 14.9 2.3 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 EFE37231.1 - 0.08 12.9 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-C2H2_4 PF13894.6 EFE37231.1 - 0.083 13.8 0.5 0.21 12.5 0.5 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger DUF1691 PF07950.11 EFE37232.1 - 1.1e-40 138.6 5.7 1.2e-32 112.8 5.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) WD40 PF00400.32 EFE37233.1 - 2.8e-31 107.0 9.9 2e-07 31.6 0.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE37233.1 - 9.5e-14 51.5 0.0 9.4e-05 22.6 0.0 4.8 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_1 PF00036.32 EFE37234.1 - 3.2e-13 48.2 4.5 3.1e-06 26.3 0.4 3.2 3 0 0 3 3 3 2 EF hand ZZ PF00569.17 EFE37234.1 - 1.2e-11 44.2 4.2 2.1e-11 43.4 4.2 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_7 PF13499.6 EFE37234.1 - 1.1e-10 41.8 7.2 3.4e-08 33.8 1.7 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFE37234.1 - 3.8e-10 38.9 3.4 0.00018 21.2 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EFE37234.1 - 6.4e-07 28.6 1.9 0.0022 17.4 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFE37234.1 - 0.00012 21.9 6.1 0.0063 16.3 0.4 3.3 4 0 0 4 4 4 2 EF-hand domain pair C1_2 PF03107.16 EFE37234.1 - 0.0074 16.6 3.4 0.016 15.5 3.4 1.5 1 0 0 1 1 1 1 C1 domain HemY_N PF07219.13 EFE37234.1 - 0.088 13.0 0.1 0.19 11.9 0.1 1.5 1 0 0 1 1 1 0 HemY protein N-terminus MFS_1 PF07690.16 EFE37235.1 - 2.5e-23 82.6 61.9 5.1e-22 78.3 40.7 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3237 PF11578.8 EFE37236.1 - 1.2e-30 106.3 0.0 1.8e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Zn_Tnp_IS91 PF14319.6 EFE37236.1 - 0.29 11.2 1.6 0.48 10.5 1.6 1.3 1 0 0 1 1 1 0 Transposase zinc-binding domain Gln-synt_C PF00120.24 EFE37237.1 - 8.5e-51 173.0 0.0 1.1e-50 172.7 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N_2 PF16952.5 EFE37238.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 1 0 1 1 1 0 Glutamine synthetase N-terminal domain adh_short_C2 PF13561.6 EFE37239.1 - 2.1e-60 204.2 0.2 2.3e-60 204.0 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE37239.1 - 4.4e-42 143.8 0.1 5.6e-42 143.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE37239.1 - 1.2e-11 44.9 0.7 1.9e-11 44.2 0.7 1.3 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EFE37239.1 - 0.00011 22.1 0.2 0.00021 21.2 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 EFE37239.1 - 0.00035 21.2 0.0 0.00075 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Polysacc_synt_2 PF02719.15 EFE37239.1 - 0.011 14.9 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EFE37239.1 - 0.016 14.7 0.1 0.023 14.1 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Lig_C PF18330.1 EFE37239.1 - 0.045 13.8 0.0 0.068 13.2 0.0 1.2 1 0 0 1 1 1 0 Ligase Pab1020 C-terminal region RecC_C PF17946.1 EFE37239.1 - 0.046 13.5 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 RecC C-terminal domain 3Beta_HSD PF01073.19 EFE37239.1 - 0.059 12.4 0.1 0.26 10.2 0.1 1.9 1 1 1 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 EFE37239.1 - 0.06 12.7 0.2 0.16 11.3 0.2 1.7 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ldh_1_N PF00056.23 EFE37239.1 - 0.062 13.4 0.9 0.28 11.3 0.5 2.0 1 1 1 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Methyltransf_12 PF08242.12 EFE37239.1 - 0.16 12.8 0.0 0.32 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ChuX_HutX PF06228.13 EFE37239.1 - 0.16 11.7 0.0 13 5.6 0.0 2.3 1 1 0 2 2 2 0 Haem utilisation ChuX/HutX Eno-Rase_NADH_b PF12242.8 EFE37239.1 - 0.43 10.4 2.7 7.2 6.5 0.6 2.4 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Myco_arth_vir_N PF09610.10 EFE37239.1 - 0.73 10.0 3.7 8.7 6.5 1.4 2.5 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) BTB PF00651.31 EFE37240.1 - 0.00046 20.4 0.0 0.012 15.9 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain Glyco_hydro_76 PF03663.14 EFE37241.1 - 2.5e-152 507.7 15.0 2.9e-152 507.4 15.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFE37241.1 - 2.2e-06 27.0 5.6 0.006 15.7 0.2 3.2 3 0 0 3 3 3 3 Glycosyl Hydrolase Family 88 CBS PF00571.28 EFE37242.1 - 1.3e-35 121.7 6.0 4.5e-09 36.6 0.0 5.6 6 0 0 6 6 6 4 CBS domain PB1 PF00564.24 EFE37242.1 - 8.7e-11 41.6 0.2 3.7e-10 39.6 0.0 2.2 2 1 0 2 2 2 1 PB1 domain Ribosomal_S26e PF01283.19 EFE37243.1 - 2e-45 153.6 14.3 1.4e-43 147.7 6.8 2.1 1 1 1 2 2 2 2 Ribosomal protein S26e zf_CopZ PF18423.1 EFE37243.1 - 0.022 14.7 0.7 0.053 13.5 0.0 1.9 2 0 0 2 2 2 0 Zinc binding domain DUF4668 PF15701.5 EFE37243.1 - 0.2 11.4 1.6 0.26 11.1 1.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4668) F-box-like PF12937.7 EFE37244.1 - 0.0036 17.1 0.3 0.01 15.7 0.3 1.7 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EFE37244.1 - 0.71 10.1 8.6 11 6.4 0.1 4.4 4 0 0 4 4 4 0 Leucine Rich repeat LRR_4 PF12799.7 EFE37244.1 - 6.7 7.3 16.6 1.5 9.4 0.2 5.1 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) Peptidase_C14 PF00656.22 EFE37246.1 - 2.6e-60 204.5 0.0 3.5e-60 204.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain DUF3099 PF11298.8 EFE37247.1 - 0.067 13.3 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) Cpn60_TCP1 PF00118.24 EFE37248.1 - 1.2e-70 238.5 0.1 1.6e-70 238.2 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_60s PF00428.19 EFE37248.1 - 0.43 11.2 3.7 0.34 11.5 1.7 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF5542 PF17696.1 EFE37249.1 - 0.021 14.9 0.5 0.044 13.9 0.5 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5542) ELFV_dehydrog PF00208.21 EFE37250.1 - 2.2e-80 269.9 0.9 2.7e-80 269.6 0.9 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EFE37250.1 - 4.4e-30 104.2 0.0 3.8e-29 101.2 0.0 2.4 1 1 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DPBB_1 PF03330.18 EFE37251.1 - 0.092 13.0 0.0 0.29 11.5 0.0 1.8 1 1 0 1 1 1 0 Lytic transglycolase DUF2749 PF10907.8 EFE37251.1 - 0.22 11.7 0.7 0.85 9.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) MFAP1 PF06991.11 EFE37253.1 - 1.6e-66 224.2 16.4 1.6e-66 224.2 16.4 3.2 2 1 1 3 3 3 1 Microfibril-associated/Pre-mRNA processing Glyco_hydro_16 PF00722.21 EFE37254.1 - 8.6e-46 155.6 2.4 1.3e-45 155.0 2.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 GATA PF00320.27 EFE37255.1 - 1.1e-05 24.9 3.4 0.0011 18.6 0.3 2.6 2 0 0 2 2 2 2 GATA zinc finger zf-RING_7 PF02591.15 EFE37255.1 - 0.14 12.3 1.9 0.31 11.3 0.9 2.1 2 0 0 2 2 2 0 C4-type zinc ribbon domain LSM PF01423.22 EFE37256.1 - 1.3e-12 47.2 0.0 1.7e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 LSM domain Dak1 PF02733.17 EFE37257.1 - 8.4e-107 356.7 1.7 1.1e-106 356.2 1.7 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EFE37257.1 - 6.8e-48 162.9 0.4 2.9e-47 160.8 0.3 2.0 2 0 0 2 2 2 1 DAK2 domain Nuc_deoxyrib_tr PF05014.15 EFE37257.1 - 0.21 11.6 0.4 0.51 10.4 0.1 1.7 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase Cullin PF00888.22 EFE37258.1 - 3e-180 600.9 5.5 3.6e-180 600.6 5.5 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EFE37258.1 - 1.7e-16 60.0 0.4 5.2e-16 58.4 0.4 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain HbrB PF08539.11 EFE37258.1 - 0.0051 16.8 0.0 0.019 15.0 0.0 2.0 1 0 0 1 1 1 1 HbrB-like Nup192 PF11894.8 EFE37259.1 - 0 1255.7 22.1 0 1255.5 22.1 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 PI3_PI4_kinase PF00454.27 EFE37260.1 - 3.1e-49 168.1 1.5 4.7e-49 167.5 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 EFE37260.1 - 2.7e-42 144.5 0.0 8.7e-42 142.8 0.0 2.0 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 EFE37260.1 - 7.6e-12 44.8 0.1 2.3e-11 43.3 0.1 1.9 1 0 0 1 1 1 1 FATC domain FAT PF02259.23 EFE37260.1 - 1.7e-05 24.2 2.6 3.6e-05 23.1 2.6 1.5 1 0 0 1 1 1 1 FAT domain UPF0052 PF01933.18 EFE37261.1 - 1.3e-53 182.2 0.0 1.8e-53 181.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 zf-C3HC4_3 PF13920.6 EFE37262.1 - 0.0024 17.7 3.8 0.9 9.5 0.0 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) RNHCP PF12647.7 EFE37262.1 - 0.0044 17.0 0.2 1.3 9.1 0.0 2.3 2 0 0 2 2 2 2 RNHCP domain DUF2367 PF10164.9 EFE37262.1 - 0.044 14.3 1.2 0.14 12.7 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) zf-RING_2 PF13639.6 EFE37262.1 - 0.078 13.3 2.0 0.23 11.8 2.0 1.8 1 1 0 1 1 1 0 Ring finger domain DUF1644 PF07800.12 EFE37262.1 - 0.11 12.5 5.1 0.37 10.9 1.1 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1644) Rad50_zn_hook PF04423.14 EFE37262.1 - 0.2 11.5 0.7 6.9 6.6 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_2 PF13923.6 EFE37262.1 - 0.41 10.5 6.3 0.92 9.4 2.9 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DNApol_Exo PF18136.1 EFE37263.1 - 7.4e-104 346.8 0.1 1.2e-103 346.1 0.1 1.3 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EFE37263.1 - 9.9e-57 192.7 0.0 1.7e-56 191.9 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 EFE37263.1 - 0.025 14.3 0.1 0.66 9.7 0.1 2.4 1 1 0 1 1 1 0 3'-5' exonuclease TFIIS_M PF07500.14 EFE37263.1 - 0.028 14.9 0.9 0.1 13.1 0.9 1.9 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain CorA PF01544.18 EFE37264.1 - 1.6e-07 30.9 0.3 0.059 12.7 0.2 3.0 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein SQS_PSY PF00494.19 EFE37265.1 - 5.6e-44 150.6 0.0 1e-43 149.8 0.0 1.4 1 1 0 1 1 1 1 Squalene/phytoene synthase Soyouz_module PF14313.6 EFE37265.1 - 0.032 14.0 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) SNF2_N PF00176.23 EFE37266.1 - 1.1e-70 238.1 0.0 1.6e-70 237.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EFE37266.1 - 8.3e-25 86.6 0.0 1.6e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EFE37266.1 - 4.1e-13 49.7 0.0 1e-12 48.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE37266.1 - 3.2e-07 30.5 0.0 7.3e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_3 PF13920.6 EFE37266.1 - 0.0002 21.2 9.5 0.00037 20.3 9.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFE37266.1 - 0.0012 18.7 5.0 0.0029 17.4 5.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE37266.1 - 0.0018 18.1 12.6 0.004 17.0 12.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE37266.1 - 0.008 16.2 11.3 0.022 14.8 11.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger UBA_4 PF14555.6 EFE37266.1 - 0.033 14.0 0.0 0.078 12.8 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain zf-RING_5 PF14634.6 EFE37266.1 - 0.059 13.3 11.0 0.14 12.2 11.0 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 EFE37266.1 - 0.088 13.2 13.3 0.11 12.9 11.9 2.0 2 0 0 2 2 1 0 Ring finger domain zf-C3HC4_5 PF17121.5 EFE37266.1 - 0.46 10.4 3.3 1 9.3 3.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFE37266.1 - 0.7 10.1 12.4 1.5 9.1 12.4 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFE37266.1 - 1.7 8.5 11.8 10 6.1 12.0 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 ADSL_C PF10397.9 EFE37267.1 - 3.2e-17 62.8 0.0 9.7e-17 61.3 0.0 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Lyase_1 PF00206.20 EFE37267.1 - 8.1e-17 61.6 0.8 6.6e-16 58.6 0.8 2.0 1 1 0 1 1 1 1 Lyase Pantoate_transf PF02548.15 EFE37267.1 - 0.068 12.5 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase GTP_EFTU PF00009.27 EFE37270.1 - 9.3e-20 71.0 0.1 2.4e-19 69.6 0.1 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFE37270.1 - 6.8e-07 29.6 0.9 2.2e-06 28.0 0.9 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFE37270.1 - 0.0019 18.3 0.1 0.0054 16.8 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFE37270.1 - 0.0039 17.1 0.1 3.4 7.6 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase PduV-EutP PF10662.9 EFE37270.1 - 0.0044 16.8 0.3 2.6 7.8 0.0 3.3 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 EFE37270.1 - 0.026 14.8 0.2 0.69 10.1 0.1 2.5 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EFE37270.1 - 0.034 14.2 3.1 0.24 11.5 0.5 2.5 2 1 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 EFE37270.1 - 0.039 13.3 0.0 0.2 11.0 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family LSM PF01423.22 EFE37271.1 - 1e-12 47.6 0.1 1.5e-12 47.0 0.1 1.4 1 1 0 1 1 1 1 LSM domain ATP13 PF12921.7 EFE37272.1 - 5.9e-27 93.8 0.0 1.2e-26 92.8 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial ATPase expression PPR_3 PF13812.6 EFE37272.1 - 8.1e-08 32.2 0.0 4e-06 26.8 0.0 2.5 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 EFE37272.1 - 6.5e-06 26.2 0.1 0.1 12.8 0.1 3.3 4 0 0 4 4 4 2 PPR repeat family Csc2 PF18320.1 EFE37272.1 - 0.003 16.6 0.0 0.0048 15.9 0.0 1.2 1 0 0 1 1 1 1 Csc2 Crispr FCD PF07729.12 EFE37272.1 - 0.0076 16.7 0.5 0.016 15.6 0.5 1.5 1 0 0 1 1 1 1 FCD domain PPR PF01535.20 EFE37272.1 - 0.026 14.7 0.3 8.7 6.8 0.1 3.4 3 0 0 3 3 3 0 PPR repeat PIG-L PF02585.17 EFE37273.1 - 1.4e-27 96.9 0.0 2.2e-27 96.3 0.0 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DnaJ PF00226.31 EFE37275.1 - 3.8e-19 68.6 0.1 1.6e-18 66.6 0.0 2.2 2 0 0 2 2 2 1 DnaJ domain RRM_1 PF00076.22 EFE37275.1 - 0.0019 18.0 0.2 0.0053 16.6 0.2 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mei4 PF13971.6 EFE37276.1 - 0.06 12.9 1.2 0.15 11.5 0.8 1.6 1 1 1 2 2 2 0 Meiosis-specific protein Mei4 DUF3930 PF13067.6 EFE37276.1 - 0.19 12.0 0.1 0.39 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3930) GCV_T PF01571.21 EFE37277.1 - 0.00012 21.6 0.0 0.00017 21.0 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DCP2 PF05026.13 EFE37279.1 - 3.9e-31 107.2 1.4 6.9e-31 106.4 1.4 1.4 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EFE37279.1 - 1.1e-16 61.0 0.1 2.6e-16 59.9 0.1 1.6 1 0 0 1 1 1 1 NUDIX domain DUF4112 PF13430.6 EFE37280.1 - 4.6e-36 123.3 0.4 6.1e-36 122.9 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) AgrD PF05931.11 EFE37280.1 - 0.093 12.8 0.3 0.17 11.9 0.3 1.4 1 0 0 1 1 1 0 Staphylococcal AgrD protein CTU2 PF10288.9 EFE37281.1 - 9.6e-11 41.9 0.5 4.2e-10 39.9 0.5 1.9 1 1 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 Lung_7-TM_R PF06814.13 EFE37282.1 - 7.6e-57 192.8 14.7 1.1e-56 192.3 14.7 1.2 1 0 0 1 1 1 1 Lung seven transmembrane receptor PALP PF00291.25 EFE37283.1 - 1.9e-33 116.2 0.0 2.3e-32 112.6 0.0 2.0 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.20 EFE37283.1 - 5.5e-08 33.3 0.0 3.5e-07 30.7 0.0 2.3 2 1 0 2 2 2 1 Rhodanese-like domain MFS_1 PF07690.16 EFE37284.1 - 6.4e-43 147.0 35.9 2.4e-39 135.3 36.7 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFE37284.1 - 7e-17 61.1 23.0 1.1e-16 60.4 23.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFE37284.1 - 4.4e-15 55.5 20.0 6.4e-13 48.4 9.2 3.3 3 0 0 3 3 3 3 Sugar (and other) transporter MMS1_N PF10433.9 EFE37285.1 - 3.7e-17 62.1 0.0 6.1e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EFE37286.1 - 6e-101 338.0 0.0 7.2e-101 337.7 0.0 1.1 1 0 0 1 1 1 1 CPSF A subunit region LysM PF01476.20 EFE37287.1 - 3e-14 52.8 0.0 4e-06 26.8 0.0 2.3 2 0 0 2 2 2 2 LysM domain SH3BGR PF04908.15 EFE37287.1 - 4.2 7.6 4.8 21 5.3 0.4 2.4 1 1 1 2 2 2 0 SH3-binding, glutamic acid-rich protein Ribosomal_S13 PF00416.22 EFE37289.1 - 5e-56 188.6 4.2 5.8e-56 188.4 4.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EFE37289.1 - 0.016 14.0 0.0 0.018 13.8 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.6 EFE37289.1 - 0.038 14.2 0.1 0.23 11.8 0.0 2.2 1 1 1 2 2 2 0 Helix-hairpin-helix motif DUF1822 PF08852.11 EFE37289.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) Peptidase_S10 PF00450.22 EFE37290.1 - 4.7e-131 438.1 0.1 5.5e-131 437.8 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 EFE37290.1 - 2.8e-06 27.9 0.2 1.1e-05 26.0 0.2 2.1 1 1 0 1 1 1 1 Carboxypeptidase Y pro-peptide SBDS_C PF09377.10 EFE37291.1 - 7.6e-43 145.2 0.0 1.1e-42 144.7 0.0 1.2 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 EFE37291.1 - 1.3e-32 111.7 0.1 2.5e-32 110.8 0.1 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein NST1 PF13945.6 EFE37291.1 - 0.028 14.6 13.8 2.1 8.4 1.1 3.2 3 0 0 3 3 3 0 Salt tolerance down-regulator Presenilin PF01080.17 EFE37291.1 - 0.032 13.0 1.7 0.046 12.5 1.7 1.2 1 0 0 1 1 1 0 Presenilin Tox-REase-9 PF15650.6 EFE37291.1 - 0.034 14.4 0.1 0.1 12.9 0.1 1.8 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 9 DUF4834 PF16118.5 EFE37291.1 - 0.097 13.7 4.6 0.14 13.1 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FYDLN_acid PF09538.10 EFE37291.1 - 0.12 13.0 5.6 2.7 8.7 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) POX PF07526.11 EFE37291.1 - 0.18 12.4 4.4 3.2 8.3 0.3 2.3 2 0 0 2 2 2 0 Associated with HOX FAM176 PF14851.6 EFE37291.1 - 0.37 10.4 8.2 2.5 7.7 0.7 2.9 3 0 0 3 3 3 0 FAM176 family DUF4820 PF16091.5 EFE37291.1 - 0.4 10.0 7.3 1.1 8.6 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Dishevelled PF02377.15 EFE37292.1 - 0.031 14.8 19.0 0.048 14.1 2.2 2.2 2 0 0 2 2 2 0 Dishevelled specific domain SOBP PF15279.6 EFE37292.1 - 1.3 9.6 17.4 0.16 12.6 10.0 2.0 2 0 0 2 2 2 0 Sine oculis-binding protein Pex14_N PF04695.13 EFE37292.1 - 6.9 7.3 13.4 3.7 8.2 5.9 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.22 EFE37292.1 - 7 5.8 12.1 0.18 11.0 2.1 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Peptidase_S8 PF00082.22 EFE37294.1 - 1.8e-13 50.4 2.5 4.6e-13 49.1 2.5 1.7 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE37294.1 - 1.3e-11 45.0 0.0 2.5e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF772 PF05598.11 EFE37294.1 - 0.0083 16.1 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Transposase domain (DUF772) USP7_ICP0_bdg PF12436.8 EFE37295.1 - 3.1e-41 141.3 0.0 1.5e-40 139.1 0.0 2.0 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 EFE37295.1 - 3.9e-23 82.3 0.4 6.4e-23 81.6 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE37295.1 - 5.3e-08 32.8 0.0 1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase BSD PF03909.17 EFE37296.1 - 1.5e-19 69.8 0.6 3.3e-19 68.6 0.6 1.6 1 0 0 1 1 1 1 BSD domain Suf PF05843.14 EFE37296.1 - 0.034 14.1 2.5 0.055 13.4 2.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) T2SSI PF02501.17 EFE37298.1 - 0.22 11.7 2.6 0.39 10.9 2.6 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I PLAC PF08686.11 EFE37298.1 - 0.35 11.6 7.7 1.7 9.5 5.6 2.2 2 0 0 2 2 2 0 PLAC (protease and lacunin) domain Frankia_peptide PF14407.6 EFE37299.1 - 0.11 12.5 0.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. WD40 PF00400.32 EFE37300.1 - 5e-08 33.5 7.5 0.021 15.7 0.0 6.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE37300.1 - 7.4e-07 29.4 0.2 0.0098 16.2 0.0 4.3 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EFE37300.1 - 0.00012 22.0 0.0 0.00024 21.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Abhydrolase_6 PF12697.7 EFE37300.1 - 0.0056 17.3 1.2 0.021 15.5 0.4 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EFE37300.1 - 0.022 14.5 0.0 0.063 13.0 0.0 1.7 1 0 0 1 1 1 0 PGAP1-like protein Nbas_N PF15492.6 EFE37300.1 - 0.03 13.6 0.1 0.16 11.3 0.0 2.3 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal 6PF2K PF01591.18 EFE37300.1 - 0.034 13.5 0.0 0.086 12.1 0.0 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_16 PF13191.6 EFE37300.1 - 0.067 13.6 0.0 0.21 12.0 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain Fructosamin_kin PF03881.14 EFE37301.1 - 3.1e-27 95.5 0.0 4.2e-27 95.1 0.0 1.1 1 0 0 1 1 1 1 Fructosamine kinase CDC45 PF02724.14 EFE37301.1 - 0.049 11.9 16.7 0.058 11.7 16.7 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_polI_A34 PF08208.11 EFE37301.1 - 0.35 10.9 20.3 0.48 10.5 20.3 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Mpp10 PF04006.12 EFE37301.1 - 1.7 7.0 28.9 2.1 6.7 28.9 1.1 1 0 0 1 1 1 0 Mpp10 protein RR_TM4-6 PF06459.12 EFE37301.1 - 3.8 7.2 22.2 5.4 6.7 22.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 EFE37301.1 - 3.9 6.4 33.8 5.2 6.0 33.8 1.1 1 0 0 1 1 1 0 Paf1 Merozoite_SPAM PF07133.11 EFE37301.1 - 7.9 6.4 46.6 11 5.9 46.6 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Aldo_ket_red PF00248.21 EFE37302.1 - 8.9e-24 84.2 0.1 4.3e-23 81.9 0.1 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.16 EFE37303.1 - 7.9e-11 41.5 25.8 2.6e-08 33.2 10.2 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE37303.1 - 3.8e-07 29.3 2.1 9.9e-07 28.0 2.1 1.7 1 0 0 1 1 1 1 Sugar (and other) transporter NADH-u_ox-rdase PF10785.9 EFE37303.1 - 0.037 14.7 0.1 0.83 10.4 0.1 3.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF92 PF01940.16 EFE37304.1 - 5.8e-83 277.9 4.1 7e-83 277.6 4.1 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 TPR_2 PF07719.17 EFE37305.1 - 4.3e-05 23.3 0.0 0.011 15.7 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Cep57_CLD_2 PF14197.6 EFE37305.1 - 0.085 13.0 0.2 0.18 11.9 0.2 1.6 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 TPR_1 PF00515.28 EFE37305.1 - 0.1 12.4 0.0 3.5 7.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFE37305.1 - 0.13 11.9 0.0 6.2 6.6 0.0 2.7 2 0 0 2 2 2 0 TPR repeat TPR_14 PF13428.6 EFE37305.1 - 0.15 13.0 0.0 9.7 7.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1635 PF07795.11 EFE37305.1 - 0.17 11.8 1.6 0.52 10.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF3716 PF12511.8 EFE37306.1 - 3.9e-18 65.2 3.1 6.3e-18 64.6 3.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Replic_Relax PF13814.6 EFE37306.1 - 0.081 13.0 0.4 0.14 12.2 0.4 1.4 1 0 0 1 1 1 0 Replication-relaxation HWE_HK PF07536.14 EFE37306.1 - 0.089 13.5 2.2 0.22 12.2 2.2 1.7 1 0 0 1 1 1 0 HWE histidine kinase DUF3138 PF11336.8 EFE37306.1 - 0.34 9.5 3.7 0.47 9.0 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Baculo_PEP_C PF04513.12 EFE37306.1 - 1 9.4 5.0 0.31 11.1 0.2 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Methyltransf_33 PF10017.9 EFE37307.1 - 1.3e-86 290.6 0.0 1.8e-86 290.1 0.0 1.1 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent DinB_2 PF12867.7 EFE37307.1 - 7.9e-07 29.6 1.7 4.3e-06 27.2 1.1 2.3 2 0 0 2 2 2 1 DinB superfamily FGE-sulfatase PF03781.16 EFE37307.1 - 1.1e-05 25.1 1.9 0.0012 18.5 0.1 2.3 1 1 1 2 2 2 2 Sulfatase-modifying factor enzyme 1 GAD-like PF08887.11 EFE37307.1 - 0.012 15.4 0.0 0.029 14.1 0.0 1.6 1 0 0 1 1 1 0 GAD-like domain Aldedh PF00171.22 EFE37309.1 - 8.5e-131 436.6 0.0 9.5e-131 436.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EFE37309.1 - 0.00026 20.2 0.0 0.00089 18.4 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA reductase (LuxC) Epimerase PF01370.21 EFE37311.1 - 6.6e-06 25.8 0.0 9.4e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Zn_clus PF00172.18 EFE37312.1 - 1.6e-05 24.9 12.1 2.9e-05 24.1 12.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FYVE PF01363.21 EFE37313.1 - 1.1e-19 70.3 1.9 1.1e-19 70.3 1.9 3.2 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 EFE37313.1 - 1.3e-07 31.9 4.2 1.3e-07 31.9 4.2 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFE37313.1 - 9.4e-06 25.4 3.3 9.4e-06 25.4 3.3 3.9 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFE37313.1 - 0.00025 20.7 4.8 0.00025 20.7 4.8 3.3 3 0 0 3 3 3 1 RING-like zinc finger zf-rbx1 PF12678.7 EFE37313.1 - 0.0017 18.6 4.1 0.0017 18.6 4.1 3.5 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFE37313.1 - 0.0042 16.9 3.6 0.0042 16.9 3.6 3.6 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Zn-C2H2_12 PF18112.1 EFE37313.1 - 0.065 13.7 7.5 0.78 10.3 1.4 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain C12orf66_like PF09404.10 EFE37313.1 - 0.21 10.4 0.5 0.34 9.7 0.5 1.3 1 0 0 1 1 1 0 KICSTOR complex C12orf66 like FYVE_2 PF02318.16 EFE37313.1 - 0.66 10.2 7.7 0.11 12.7 0.5 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger RINGv PF12906.7 EFE37313.1 - 1 9.6 8.7 1.4 9.1 4.8 2.8 2 0 0 2 2 2 0 RING-variant domain Ras PF00071.22 EFE37315.1 - 1.8e-29 102.4 1.3 7.4e-24 84.2 0.0 3.1 3 0 0 3 3 3 3 Ras family Roc PF08477.13 EFE37315.1 - 0.00036 20.7 0.3 0.25 11.5 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE37315.1 - 0.001 18.6 0.0 0.015 14.7 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFE37315.1 - 0.023 14.6 0.1 5.4 6.9 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Carboxyl_trans PF01039.22 EFE37316.1 - 1.6e-139 465.8 0.0 2e-139 465.4 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 EFE37316.1 - 0.034 13.6 0.0 8.4 5.8 0.0 2.4 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Acyl-CoA_dh_1 PF00441.24 EFE37317.1 - 6.2e-40 136.8 0.5 1.2e-39 135.9 0.5 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFE37317.1 - 3e-35 121.3 0.1 6.5e-35 120.2 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFE37317.1 - 1.8e-26 92.2 0.1 3.6e-26 91.2 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFE37317.1 - 4.9e-15 56.0 0.1 9.9e-15 55.0 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EFE37317.1 - 0.00019 21.2 0.3 0.00047 19.9 0.3 1.6 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal CPSase_L_D2 PF02786.17 EFE37319.1 - 1.3e-73 247.0 0.0 1.9e-73 246.4 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EFE37319.1 - 3.1e-36 123.8 0.0 6.7e-36 122.7 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 EFE37319.1 - 3.3e-35 120.9 0.0 6.9e-35 119.9 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 EFE37319.1 - 8.2e-13 48.0 2.5 2.4e-12 46.5 2.5 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EFE37319.1 - 3e-09 36.7 0.0 6.3e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EFE37319.1 - 3.1e-08 33.4 0.0 6.4e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EFE37319.1 - 0.00074 19.6 0.0 0.0015 18.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EFE37319.1 - 0.0038 17.0 0.0 0.0069 16.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 EFE37319.1 - 0.013 14.8 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp Biotin_lipoyl_2 PF13533.6 EFE37319.1 - 0.016 15.0 0.2 0.15 11.9 0.0 2.3 1 1 1 2 2 2 0 Biotin-lipoyl like GCV_H PF01597.19 EFE37319.1 - 0.019 14.8 0.2 0.051 13.5 0.2 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein ATP-grasp_4 PF13535.6 EFE37319.1 - 0.029 14.0 0.0 0.094 12.3 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.11 EFE37319.1 - 0.16 11.6 0.0 0.72 9.4 0.0 2.1 3 0 0 3 3 3 0 RimK-like ATP-grasp domain adh_short_C2 PF13561.6 EFE37320.1 - 3.4e-52 177.3 0.0 4.5e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE37320.1 - 1.2e-35 122.7 0.0 2e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE37320.1 - 1.5e-11 44.5 0.1 2.7e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EFE37320.1 - 0.026 14.0 0.0 1.8 7.8 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DUF1752 PF08550.10 EFE37321.1 - 2e-10 40.3 3.5 4.2e-10 39.3 3.5 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF5327 PF17261.2 EFE37321.1 - 0.51 11.1 4.1 1.1 10.0 0.2 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5327) MARVEL PF01284.23 EFE37322.1 - 2.4e-10 40.6 3.5 3.7e-10 40.0 3.5 1.3 1 1 0 1 1 1 1 Membrane-associating domain Roughex PF06020.11 EFE37323.1 - 0.16 11.0 11.2 0.69 8.9 0.2 2.5 2 0 0 2 2 2 0 Drosophila roughex protein Otopetrin PF03189.13 EFE37323.1 - 1.1 8.0 3.0 0.99 8.1 0.1 2.0 2 0 0 2 2 2 0 Otopetrin TFIIA PF03153.13 EFE37323.1 - 3 7.7 38.8 0.021 14.9 24.5 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.6 EFE37323.1 - 3.2 7.0 9.3 5.7 6.2 9.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HflK_N PF12221.8 EFE37323.1 - 9.7 6.3 7.3 79 3.4 0.0 3.7 3 0 0 3 3 3 0 Bacterial membrane protein N terminal PHD PF00628.29 EFE37324.1 - 6.5e-10 38.8 1.7 1.5e-09 37.6 1.7 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EFE37324.1 - 0.0006 19.3 2.3 0.0011 18.4 2.3 1.5 1 0 0 1 1 1 1 PHD-finger PigN PF04987.14 EFE37325.1 - 4.4e-147 490.6 28.4 5.4e-147 490.3 28.4 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Sulfatase PF00884.23 EFE37325.1 - 3.4e-09 36.5 0.2 5.5e-09 35.8 0.2 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EFE37325.1 - 1e-07 31.9 3.4 3.1e-06 27.0 3.4 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EFE37325.1 - 0.00014 21.3 0.0 0.00025 20.5 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Alk_phosphatase PF00245.20 EFE37325.1 - 0.068 12.1 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Alkaline phosphatase F-box-like_2 PF13013.6 EFE37326.1 - 0.0057 16.6 0.2 0.0097 15.9 0.2 1.7 1 1 0 1 1 1 1 F-box-like domain eIF-5a PF01287.20 EFE37327.1 - 0.00027 21.0 0.1 0.00053 20.0 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold FYRN PF05964.14 EFE37327.1 - 0.61 10.0 2.1 0.63 9.9 0.1 2.1 2 0 0 2 2 2 0 F/Y-rich N-terminus RCR PF12273.8 EFE37327.1 - 5.4 7.7 10.4 28 5.4 8.6 2.8 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red MFS_1 PF07690.16 EFE37328.1 - 1.1e-42 146.2 19.2 1.1e-42 146.2 19.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE37328.1 - 6e-10 38.6 4.2 1.1e-09 37.8 4.2 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter CPP1-like PF11833.8 EFE37328.1 - 0.045 13.4 3.2 0.1 12.2 3.2 1.6 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like OATP PF03137.20 EFE37328.1 - 0.06 11.6 2.1 0.078 11.3 1.4 1.5 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family YhhN PF07947.14 EFE37329.1 - 1.5e-41 142.0 4.2 2.4e-41 141.4 4.2 1.3 1 0 0 1 1 1 1 YhhN family HATPase_c_4 PF13749.6 EFE37330.1 - 0.077 13.1 0.0 0.23 11.6 0.0 1.8 1 0 0 1 1 1 0 Putative ATP-dependent DNA helicase recG C-terminal Abhydrolase_1 PF00561.20 EFE37333.1 - 3.2e-19 69.6 0.1 1.2e-15 57.8 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE37333.1 - 4.3e-17 63.4 7.8 3e-16 60.7 7.8 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFE37333.1 - 2.3e-08 33.6 0.1 6.5e-08 32.1 0.3 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EFE37333.1 - 0.0045 15.9 0.0 0.0068 15.3 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EFE37333.1 - 0.018 14.1 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Peptidase_S9 PF00326.21 EFE37333.1 - 0.045 13.2 0.1 0.22 11.0 0.2 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Esterase PF00756.20 EFE37333.1 - 0.075 12.7 0.1 0.2 11.3 0.1 1.7 1 1 0 1 1 1 0 Putative esterase SRR1 PF07985.12 EFE37336.1 - 3.2e-06 27.1 0.1 6e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 SRR1 RRP7 PF12923.7 EFE37336.1 - 0.033 14.3 1.0 0.048 13.8 0.2 1.6 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain bZIP_1 PF00170.21 EFE37337.1 - 0.0064 16.6 4.4 0.01 15.9 4.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor DivIC PF04977.15 EFE37337.1 - 0.041 13.7 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Septum formation initiator YabA PF06156.13 EFE37337.1 - 0.1 13.2 0.0 0.27 11.9 0.0 1.6 1 1 0 1 1 1 0 Initiation control protein YabA ABM PF03992.16 EFE37338.1 - 0.0012 18.9 0.6 0.25 11.5 0.0 2.8 2 1 0 2 2 2 2 Antibiotic biosynthesis monooxygenase MFS_1 PF07690.16 EFE37339.1 - 3.5e-39 134.7 54.3 3.5e-39 134.7 54.3 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE37339.1 - 1.2e-17 63.6 25.0 1.5e-17 63.3 25.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans PF04082.18 EFE37340.1 - 0.0071 15.4 0.0 0.0071 15.4 0.0 3.2 4 2 0 4 4 4 1 Fungal specific transcription factor domain PAT1 PF09770.9 EFE37340.1 - 0.11 10.8 12.5 0.15 10.3 12.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Androgen_recep PF02166.16 EFE37340.1 - 0.15 10.9 14.9 0.21 10.4 14.9 1.1 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 EFE37340.1 - 0.16 11.5 18.5 0.24 11.0 18.5 1.2 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 EFE37340.1 - 1.2 10.1 4.5 2.6 9.1 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 EFE37340.1 - 1.8 8.5 19.1 2.6 8.0 19.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Plasmodium_Vir PF05795.11 EFE37340.1 - 3.7 6.9 6.9 0.47 9.8 2.9 1.4 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Presenilin PF01080.17 EFE37340.1 - 6.2 5.5 5.2 9 4.9 5.2 1.1 1 0 0 1 1 1 0 Presenilin MFS_1 PF07690.16 EFE37342.1 - 5.1e-15 55.3 47.2 1.7e-11 43.7 28.8 3.3 2 1 0 2 2 2 2 Major Facilitator Superfamily RHD3 PF05879.12 EFE37343.1 - 8.4e-290 963.2 0.0 2e-217 723.9 0.0 2.0 1 1 1 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EFE37343.1 - 3.1e-07 29.9 0.1 5.8e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 EFE37343.1 - 9.1e-06 25.8 0.1 1.8e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 EFE37343.1 - 7e-05 23.1 0.1 0.0004 20.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFE37343.1 - 0.00013 22.0 0.1 0.0003 20.9 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EFE37343.1 - 0.00051 19.4 0.2 0.0012 18.2 0.2 1.6 1 0 0 1 1 1 1 Septin DIM1 PF02966.16 EFE37344.1 - 8.4e-69 229.5 0.1 9.4e-69 229.3 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EFE37344.1 - 0.0037 17.2 0.0 0.0045 17.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFE37344.1 - 0.16 12.3 0.5 0.29 11.5 0.5 1.5 1 1 0 1 1 1 0 Thioredoxin-like 4HBT_2 PF13279.6 EFE37345.1 - 0.00015 22.2 0.0 0.00018 22.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily HIG_1_N PF04588.13 EFE37346.1 - 2.8e-06 27.4 0.2 2.8e-06 27.4 0.2 2.0 3 0 0 3 3 3 1 Hypoxia induced protein conserved region Med26 PF08711.11 EFE37347.1 - 1.9e-09 37.4 0.0 4e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Nup54 PF13874.6 EFE37348.1 - 2.4e-41 141.1 0.4 2.4e-41 141.1 0.4 2.9 3 0 0 3 3 3 1 Nucleoporin complex subunit 54 Nup54_57_C PF18570.1 EFE37348.1 - 9.4e-13 47.5 1.3 1.6e-12 46.7 1.3 1.4 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain Nucleoporin_FG PF13634.6 EFE37348.1 - 9e-09 36.1 35.1 9e-09 36.1 35.1 2.5 1 1 1 2 2 2 1 Nucleoporin FG repeat region Fib_alpha PF08702.10 EFE37348.1 - 0.0027 17.9 0.7 0.0027 17.9 0.7 1.9 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family FliT PF05400.13 EFE37348.1 - 1.9 9.3 8.7 1.3 9.9 2.0 3.3 2 1 1 3 3 3 0 Flagellar protein FliT AAA PF00004.29 EFE37349.1 - 5.4e-16 59.2 0.0 1.3e-15 58.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 EFE37349.1 - 1.7e-12 47.3 1.2 8.9e-12 45.0 0.6 2.2 2 0 0 2 2 2 1 AAA lid domain AAA_16 PF13191.6 EFE37349.1 - 1.7e-12 48.0 0.2 1.6e-10 41.6 0.0 3.3 3 2 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EFE37349.1 - 1e-09 38.8 0.0 1e-08 35.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFE37349.1 - 0.00032 20.6 0.1 0.0016 18.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFE37349.1 - 0.0007 20.0 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFE37349.1 - 0.0013 19.0 0.0 0.0039 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EFE37349.1 - 0.0051 16.1 0.0 0.014 14.6 0.0 1.7 2 0 0 2 2 2 1 KAP family P-loop domain NACHT PF05729.12 EFE37349.1 - 0.01 15.8 0.0 0.032 14.1 0.0 1.8 1 1 0 1 1 1 0 NACHT domain BAH PF01426.18 EFE37349.1 - 0.016 15.1 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 BAH domain RNA_helicase PF00910.22 EFE37349.1 - 0.017 15.5 0.0 0.092 13.1 0.0 2.3 3 0 0 3 3 2 0 RNA helicase ATPase_2 PF01637.18 EFE37349.1 - 0.019 14.9 0.0 0.28 11.0 0.0 2.2 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea DUF2075 PF09848.9 EFE37349.1 - 0.021 14.0 0.0 0.52 9.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 EFE37349.1 - 0.026 14.7 0.0 0.28 11.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 EFE37349.1 - 0.028 13.4 0.0 0.044 12.7 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 EFE37349.1 - 0.035 13.6 0.0 0.3 10.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region PIF1 PF05970.14 EFE37349.1 - 0.07 12.3 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase WD40 PF00400.32 EFE37350.1 - 3e-43 145.0 14.3 9.8e-10 38.9 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE37350.1 - 1.3e-05 25.4 0.4 1.7 9.0 0.0 4.7 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE37350.1 - 0.013 14.1 1.7 12 4.4 0.0 3.8 1 1 3 4 4 4 0 Nucleoporin Nup120/160 WD40_like PF17005.5 EFE37350.1 - 0.25 10.6 0.0 1.1 8.5 0.0 2.0 2 0 0 2 2 2 0 WD40-like domain Ank_2 PF12796.7 EFE37351.1 - 6.1e-41 138.9 1.4 1.4e-14 54.4 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE37351.1 - 9.2e-35 118.6 4.0 4.8e-09 36.6 0.0 5.3 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE37351.1 - 2.1e-29 101.2 0.6 4.8e-09 36.3 0.0 4.6 2 2 4 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE37351.1 - 2e-27 92.2 0.4 0.0007 19.9 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 EFE37351.1 - 4.5e-21 74.3 0.8 0.0017 18.7 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeat Shal-type PF11601.8 EFE37351.1 - 0.12 11.9 0.9 0.25 10.9 0.0 1.9 2 0 0 2 2 2 0 Shal-type voltage-gated potassium channels, N-terminal TMF_TATA_bd PF12325.8 EFE37352.1 - 5e-40 136.3 13.4 5e-40 136.3 13.4 7.1 3 1 2 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EFE37352.1 - 6.4e-23 80.5 19.0 6.4e-23 80.5 19.0 8.3 5 3 2 7 7 7 1 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 EFE37352.1 - 7.3e-05 23.1 3.8 7.3e-05 23.1 3.8 6.2 3 1 3 6 6 6 1 Autophagy protein 16 (ATG16) FH2 PF02181.23 EFE37352.1 - 0.0053 15.9 1.9 0.0053 15.9 1.9 5.0 3 2 2 5 5 5 1 Formin Homology 2 Domain Muted PF14942.6 EFE37352.1 - 0.013 15.9 6.5 0.013 15.9 6.5 6.1 2 1 5 7 7 7 0 Organelle biogenesis, Muted-like protein Pkinase PF00069.25 EFE37353.1 - 8.3e-13 48.3 0.0 1.1e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37353.1 - 4e-12 46.0 0.0 1.4e-11 44.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Crystall_2 PF09076.10 EFE37353.1 - 0.052 13.4 0.0 0.3 11.0 0.0 2.1 2 0 0 2 2 2 0 Beta/Gamma crystallin V-ATPase_H_N PF03224.14 EFE37354.1 - 6.4e-81 272.1 0.0 9.2e-81 271.6 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EFE37354.1 - 1.4e-34 118.7 0.0 3.9e-34 117.3 0.0 1.8 1 0 0 1 1 1 1 V-ATPase subunit H Spc7 PF08317.11 EFE37355.1 - 0.0057 15.6 7.4 0.0057 15.6 7.4 5.2 4 1 1 5 5 5 3 Spc7 kinetochore protein Noelin-1 PF12308.8 EFE37355.1 - 0.077 13.0 0.3 0.077 13.0 0.3 5.1 5 1 1 6 6 6 0 Neurogenesis glycoprotein ATP_bind_1 PF03029.17 EFE37357.1 - 7.8e-77 258.3 0.0 9e-77 258.1 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 EFE37357.1 - 3e-05 23.9 0.0 6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 EFE37357.1 - 0.00011 22.2 0.0 0.00043 20.3 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFE37357.1 - 0.00052 20.4 0.0 0.0017 18.8 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 EFE37357.1 - 0.0019 18.3 0.0 0.0023 18.0 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_7 PF12775.7 EFE37357.1 - 0.0023 17.5 0.0 0.014 14.9 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFE37357.1 - 0.0026 18.0 0.0 0.0047 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EFE37357.1 - 0.0041 17.5 0.0 0.0099 16.3 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 EFE37357.1 - 0.0043 17.6 0.0 0.0079 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFE37357.1 - 0.0044 16.8 0.0 0.0078 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 EFE37357.1 - 0.0046 16.5 0.0 2.6 7.6 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain SRP54 PF00448.22 EFE37357.1 - 0.0053 16.4 0.0 0.0092 15.6 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA PF00004.29 EFE37357.1 - 0.0056 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EFE37357.1 - 0.0057 16.8 0.0 0.0076 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFE37357.1 - 0.0068 16.7 0.0 0.07 13.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF463 PF04317.12 EFE37357.1 - 0.013 14.4 0.0 0.021 13.7 0.0 1.3 1 0 0 1 1 1 0 YcjX-like family, DUF463 ATPase_2 PF01637.18 EFE37357.1 - 0.016 15.1 0.0 0.19 11.6 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EFE37357.1 - 0.019 14.9 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 EFE37357.1 - 0.028 14.1 0.0 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EFE37357.1 - 0.029 13.7 0.0 0.089 12.1 0.0 1.7 2 0 0 2 2 2 0 KaiC T2SSE PF00437.20 EFE37357.1 - 0.031 13.3 0.0 0.046 12.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_31 PF13614.6 EFE37357.1 - 0.035 14.0 0.0 5.9 6.8 0.0 2.4 1 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EFE37357.1 - 0.039 14.0 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Septin PF00735.18 EFE37357.1 - 0.045 13.0 0.0 0.08 12.2 0.0 1.4 1 0 0 1 1 1 0 Septin KAP_NTPase PF07693.14 EFE37357.1 - 0.061 12.6 0.0 0.094 11.9 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain AAA_5 PF07728.14 EFE37357.1 - 0.081 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 EFE37357.1 - 0.088 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.27 EFE37357.1 - 0.089 13.3 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Pox_A32 PF04665.12 EFE37357.1 - 0.1 12.0 0.0 0.13 11.7 0.0 1.4 1 1 0 1 1 1 0 Poxvirus A32 protein cobW PF02492.19 EFE37357.1 - 0.12 11.9 0.1 0.54 9.8 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PPV_E1_C PF00519.17 EFE37357.1 - 0.15 10.9 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase NB-ARC PF00931.22 EFE37357.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain KTI12 PF08433.10 EFE37357.1 - 0.16 11.4 0.0 0.34 10.3 0.0 1.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 IstB_IS21 PF01695.17 EFE37357.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 EFE37357.1 - 0.19 11.4 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain S-AdoMet_synt_C PF02773.16 EFE37358.1 - 1.2e-66 222.9 1.3 8e-66 220.2 0.1 2.1 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EFE37358.1 - 1.8e-46 157.3 0.0 2.9e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EFE37358.1 - 2.4e-14 53.8 0.3 1.1e-13 51.6 0.0 2.2 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain SLD3 PF08639.10 EFE37359.1 - 8.5e-156 519.9 11.9 8.5e-156 519.9 11.9 1.8 2 0 0 2 2 2 1 DNA replication regulator SLD3 PI3K_1B_p101 PF10486.9 EFE37361.1 - 1.4 6.6 4.6 1.4 6.7 4.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PhoLip_ATPase_C PF16212.5 EFE37362.1 - 1.2e-69 234.9 20.8 1.2e-69 234.9 20.8 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFE37362.1 - 4e-25 87.3 2.6 1.4e-23 82.4 0.1 2.6 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EFE37362.1 - 5.8e-14 52.9 0.2 2.6e-06 27.9 0.0 2.5 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE37362.1 - 7.3e-13 48.4 0.0 4.3e-12 45.9 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFE37362.1 - 2.9e-11 43.2 0.1 9.8e-11 41.5 0.1 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFE37362.1 - 0.0027 17.5 0.1 0.0094 15.7 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase G_glu_transpept PF01019.21 EFE37363.1 - 7.2e-123 411.1 0.0 8.1e-123 410.9 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase HHH_3 PF12836.7 EFE37363.1 - 0.15 12.3 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif p450 PF00067.22 EFE37364.1 - 4.4e-27 94.9 0.0 7.4e-27 94.2 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 NADHdeh_related PF10125.9 EFE37365.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 NADH dehydrogenase I, subunit N related protein Sugar_tr PF00083.24 EFE37367.1 - 2.6e-84 283.7 20.8 3e-84 283.5 20.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE37367.1 - 1.4e-14 53.9 33.8 4e-14 52.3 24.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Peptidase_S8 PF00082.22 EFE37368.1 - 1.1e-28 100.3 16.4 3.1e-28 98.9 16.4 1.6 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE37368.1 - 6.1e-15 55.7 0.5 9.5e-15 55.0 0.5 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF3553 PF12073.8 EFE37368.1 - 0.093 12.5 0.0 0.34 10.7 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3553) Nramp PF01566.18 EFE37369.1 - 4.6e-74 249.5 28.6 2.9e-42 144.9 7.6 3.7 2 1 1 3 3 3 2 Natural resistance-associated macrophage protein Aminotran_4 PF01063.19 EFE37370.1 - 3.5e-27 95.7 0.0 4.6e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV TPR_1 PF00515.28 EFE37371.1 - 1.1e-40 135.8 34.1 4.9e-06 26.1 0.1 11.4 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.17 EFE37371.1 - 2.4e-39 130.3 33.6 7.9e-05 22.5 0.1 11.6 10 1 1 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 EFE37371.1 - 1.1e-23 81.4 26.2 0.00031 20.7 0.0 10.7 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFE37371.1 - 6.3e-21 74.7 21.9 8e-06 26.4 0.1 7.0 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFE37371.1 - 2.5e-20 71.9 28.7 1.2e-06 28.1 0.1 9.2 6 2 4 10 10 10 5 TPR repeat TPR_17 PF13431.6 EFE37371.1 - 1.2e-17 62.9 17.8 0.019 15.3 0.0 9.1 8 2 0 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.6 EFE37371.1 - 1.2e-16 60.8 35.8 0.00021 21.5 2.6 8.6 3 2 6 9 9 9 8 Tetratricopeptide repeat TPR_19 PF14559.6 EFE37371.1 - 7.6e-14 52.0 30.4 5.5e-06 26.8 2.4 7.9 7 2 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFE37371.1 - 2.4e-13 50.0 15.6 3.8e-05 23.7 0.1 6.5 4 2 4 8 8 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFE37371.1 - 7.3e-13 47.6 22.9 0.0097 15.9 0.6 9.7 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFE37371.1 - 2.7e-11 43.3 25.6 0.038 14.8 1.1 10.1 3 3 9 12 12 11 4 Tetratricopeptide repeat TPR_10 PF13374.6 EFE37371.1 - 6.1e-07 29.1 28.0 0.052 13.4 1.0 9.5 11 0 0 11 11 10 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE37371.1 - 7e-07 29.4 19.0 0.087 13.1 0.4 5.9 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 EFE37371.1 - 2.7e-06 27.0 9.7 0.0001 21.8 4.8 4.0 2 1 1 3 3 3 2 MalT-like TPR region SHNi-TPR PF10516.9 EFE37371.1 - 0.00012 21.5 14.6 0.18 11.3 0.0 7.8 8 0 0 8 8 8 1 SHNi-TPR TAF1_subA PF14929.6 EFE37371.1 - 0.0033 16.9 0.8 0.0086 15.5 0.4 1.9 2 1 0 2 2 2 1 TAF RNA Polymerase I subunit A MAS20 PF02064.15 EFE37371.1 - 0.0038 17.3 7.1 0.022 14.8 0.5 4.0 4 1 1 5 5 5 1 MAS20 protein import receptor DUF3856 PF12968.7 EFE37371.1 - 0.0086 16.2 5.1 7.2 6.7 0.0 4.9 4 3 0 4 4 4 0 Domain of Unknown Function (DUF3856) AP3D1 PF06375.11 EFE37371.1 - 0.011 16.0 2.7 0.02 15.1 2.7 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 TPR_4 PF07721.14 EFE37371.1 - 0.02 15.4 4.5 1.7e+02 3.3 0.2 6.6 7 0 0 7 7 6 0 Tetratricopeptide repeat Sel1 PF08238.12 EFE37371.1 - 0.028 15.1 6.2 0.92 10.3 0.1 4.2 4 0 0 4 4 2 0 Sel1 repeat MIT PF04212.18 EFE37371.1 - 0.049 13.7 14.7 9 6.4 0.3 6.7 7 0 0 7 7 6 0 MIT (microtubule interacting and transport) domain Wzy_C_2 PF11846.8 EFE37371.1 - 0.073 13.0 1.3 21 4.9 0.0 3.6 4 0 0 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal FAT PF02259.23 EFE37371.1 - 0.095 11.9 3.1 8.5 5.5 0.3 3.1 3 0 0 3 3 3 0 FAT domain TPR_6 PF13174.6 EFE37371.1 - 0.57 10.9 29.0 9.6 7.1 0.9 9.2 11 0 0 11 11 9 0 Tetratricopeptide repeat DNApol_Exo PF18136.1 EFE37371.1 - 1.8 7.7 4.8 35 3.4 0.0 2.3 1 1 1 2 2 2 0 DNA mitochondrial polymerase exonuclease domain DUF4551 PF15087.6 EFE37372.1 - 9.9 4.9 20.8 12 4.6 20.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Amidohydro_1 PF01979.20 EFE37373.1 - 1.5e-73 248.1 0.2 2.9e-73 247.2 0.2 1.5 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 EFE37373.1 - 4.4e-54 181.9 1.5 9e-54 181.0 1.5 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 EFE37373.1 - 1.5e-40 137.1 0.2 1.2e-39 134.3 0.0 2.2 2 0 0 2 2 2 1 Urease beta subunit Urease_gamma PF00547.18 EFE37373.1 - 6.7e-38 129.0 0.1 1.6e-37 127.8 0.1 1.7 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 EFE37373.1 - 2.7e-07 30.4 0.1 0.00021 20.9 0.0 2.6 2 1 1 3 3 3 2 Amidohydrolase family DRMBL PF07522.14 EFE37374.1 - 0.00019 21.6 0.8 0.0006 20.0 0.0 2.2 2 1 0 2 2 2 1 DNA repair metallo-beta-lactamase VID27_N PF17748.1 EFE37374.1 - 0.028 14.3 0.6 0.064 13.1 0.6 1.6 1 0 0 1 1 1 0 VID27 N-terminal region DUF3925 PF13063.6 EFE37376.1 - 0.017 15.3 0.9 0.027 14.7 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3925) AP3D1 PF06375.11 EFE37377.1 - 1.7 8.9 10.6 2 8.6 10.6 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 MaoC_dehydrat_N PF13452.6 EFE37378.1 - 0.15 12.2 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase VHS PF00790.19 EFE37379.1 - 1.2e-29 103.0 0.1 7.2e-29 100.4 0.0 2.2 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 EFE37379.1 - 1.1e-20 73.7 0.8 1.1e-20 73.7 0.8 2.5 3 0 0 3 3 3 1 GAT domain GGA_N-GAT PF18308.1 EFE37379.1 - 1.6e-07 30.8 1.7 9.4e-07 28.4 0.1 2.7 2 0 0 2 2 2 1 GGA N-GAT domain Alpha_adaptinC2 PF02883.20 EFE37379.1 - 0.0025 18.1 0.2 0.0025 18.1 0.2 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain Ribo_biogen_C PF04034.13 EFE37380.1 - 2.7e-32 111.2 0.2 4.1e-32 110.6 0.2 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal Peptidase_C37 PF05416.12 EFE37380.1 - 0.0041 15.7 4.6 0.0054 15.3 4.6 1.1 1 0 0 1 1 1 1 Southampton virus-type processing peptidase BUD22 PF09073.10 EFE37380.1 - 0.1 11.9 14.7 0.13 11.6 14.7 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EFE37380.1 - 5.4 5.1 16.6 6.8 4.8 16.6 1.2 1 0 0 1 1 1 0 Nop14-like family Herpes_pp85 PF04637.12 EFE37380.1 - 6.8 5.0 5.9 9.1 4.6 5.9 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) zf-H2C2 PF09337.10 EFE37381.1 - 1.2e-14 54.3 2.2 2.7e-14 53.1 2.2 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 EFE37381.1 - 7e-10 38.9 0.5 7e-10 38.9 0.5 2.5 3 0 0 3 3 3 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 EFE37381.1 - 0.00035 20.8 0.0 0.00081 19.6 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EFE37381.1 - 0.015 15.5 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFE37381.1 - 0.11 13.2 0.0 0.33 11.6 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Cpn60_TCP1 PF00118.24 EFE37382.1 - 5.7e-66 223.1 3.1 6.5e-66 222.9 3.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family RP-C_C PF11800.8 EFE37383.1 - 1 9.4 7.2 0.41 10.7 4.2 1.8 2 0 0 2 2 2 0 Replication protein C C-terminal region BCS1_N PF08740.11 EFE37384.1 - 2e-48 164.9 0.8 7.9e-48 162.9 1.2 1.7 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EFE37384.1 - 2.4e-16 60.3 0.0 3.9e-08 33.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFE37384.1 - 0.0012 18.6 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFE37384.1 - 0.029 14.7 0.1 0.069 13.5 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EFE37384.1 - 0.047 14.2 0.1 0.23 12.0 0.0 2.3 3 0 0 3 3 3 0 AAA domain ATPase PF06745.13 EFE37384.1 - 0.082 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 KaiC Polyoma_lg_T_C PF06431.11 EFE37384.1 - 0.11 11.4 0.0 0.11 11.4 0.0 1.5 2 0 0 2 2 2 0 Polyomavirus large T antigen C-terminus HNH_2 PF13391.6 EFE37385.1 - 2.7e-08 33.8 0.1 7.9e-08 32.3 0.1 1.8 1 0 0 1 1 1 1 HNH endonuclease TFIIA PF03153.13 EFE37386.1 - 8 6.3 19.5 12 5.7 19.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SRP19 PF01922.17 EFE37388.1 - 6.1e-33 113.6 0.1 1.9e-32 112.1 0.0 1.8 2 0 0 2 2 2 1 SRP19 protein TCTP PF00838.17 EFE37389.1 - 1.5e-31 110.0 0.2 1.6e-31 109.9 0.2 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF2717 PF10911.8 EFE37389.1 - 0.09 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2717) TCTP PF00838.17 EFE37390.1 - 6.4e-28 98.2 1.4 8.1e-28 97.8 1.4 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein Imp-YgjV PF10688.9 EFE37390.1 - 0.01 15.6 1.9 0.016 15.0 1.9 1.3 1 0 0 1 1 1 0 Bacterial inner membrane protein EXS PF03124.14 EFE37390.1 - 0.021 14.2 2.1 0.024 14.0 2.1 1.1 1 0 0 1 1 1 0 EXS family SUB1_ProdP9 PF18213.1 EFE37390.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 TMEM232 PF15877.5 EFE37390.1 - 0.1 11.6 0.5 0.12 11.3 0.5 1.1 1 0 0 1 1 1 0 Transmembrane protein family 232 GMC_oxred_N PF00732.19 EFE37391.1 - 1.3e-46 159.3 0.5 1.8e-46 158.8 0.5 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFE37391.1 - 2.6e-29 102.6 0.3 2.8e-28 99.2 0.0 2.4 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EFE37391.1 - 4.9e-07 29.2 0.3 3.1e-05 23.2 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EFE37391.1 - 7.8e-05 22.0 0.3 0.0003 20.1 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFE37391.1 - 0.0016 17.7 0.1 0.012 14.8 0.1 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 EFE37391.1 - 0.005 16.1 0.0 0.0082 15.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EFE37391.1 - 0.018 14.4 0.5 0.032 13.6 0.5 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE37391.1 - 0.034 14.4 1.7 0.12 12.7 0.7 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFE37391.1 - 0.19 12.3 0.2 0.87 10.2 0.4 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE37391.1 - 0.21 10.8 0.0 3.8 6.7 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Bul1_N PF04425.12 EFE37395.1 - 2.7e-05 23.1 0.4 5.9e-05 22.0 0.3 1.5 1 1 1 2 2 2 1 Bul1 N terminus Arrestin_N PF00339.29 EFE37395.1 - 0.00041 20.4 0.0 0.0013 18.8 0.0 1.8 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 EFE37395.1 - 0.003 17.0 0.0 0.011 15.2 0.0 1.7 2 0 0 2 2 2 1 Bul1 C terminus SMI1_KNR4 PF09346.10 EFE37396.1 - 9.7e-34 116.6 0.0 1.9e-33 115.7 0.0 1.5 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) Thioredoxin PF00085.20 EFE37397.1 - 0.00092 19.2 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Osteopontin PF00865.18 EFE37397.1 - 0.39 10.2 19.4 0.31 10.5 8.4 2.2 2 0 0 2 2 2 0 Osteopontin Peptidase_M14 PF00246.24 EFE37398.1 - 1.8e-80 270.8 0.0 8.7e-80 268.6 0.0 1.8 2 0 0 2 2 2 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EFE37398.1 - 2.4e-10 40.6 1.4 6.1e-10 39.4 0.1 2.4 3 0 0 3 3 3 1 Carboxypeptidase activation peptide AstE_AspA PF04952.14 EFE37398.1 - 0.19 10.8 0.1 0.31 10.1 0.1 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Methyltransf_25 PF13649.6 EFE37399.1 - 2e-13 50.9 0.0 4e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE37399.1 - 1.7e-09 38.2 0.0 2.8e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE37399.1 - 4e-08 33.3 0.0 5.3e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE37399.1 - 6.2e-08 33.3 0.0 1.6e-07 32.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE37399.1 - 1.3e-07 31.5 0.0 1.7e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EFE37399.1 - 0.0049 16.3 0.0 0.0076 15.7 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Ubie_methyltran PF01209.18 EFE37399.1 - 0.0082 15.5 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 EFE37399.1 - 0.013 15.2 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_20 PF12147.8 EFE37399.1 - 0.015 14.5 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase MTS PF05175.14 EFE37399.1 - 0.036 13.6 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain FSH1 PF03959.13 EFE37400.1 - 3.9e-29 101.9 0.0 5e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EFE37400.1 - 0.024 14.5 0.5 0.84 9.4 0.3 2.6 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EFE37400.1 - 0.073 12.7 0.0 0.16 11.5 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold HSBP1 PF06825.12 EFE37401.1 - 2.2e-06 27.4 4.4 0.061 13.2 0.0 5.1 5 0 0 5 5 5 2 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.12 EFE37401.1 - 0.0002 21.4 32.5 0.033 14.2 1.0 5.6 3 2 2 6 6 6 4 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.6 EFE37401.1 - 0.00096 18.5 0.1 0.00096 18.5 0.1 5.3 2 1 3 5 5 5 1 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 EFE37401.1 - 0.0049 17.2 22.9 0.68 10.4 1.9 7.0 7 2 1 8 8 8 1 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EFE37401.1 - 0.005 16.9 23.6 0.92 9.6 0.6 5.5 4 3 1 5 5 5 2 Protein of unknown function (DUF1664) DUF1043 PF06295.12 EFE37401.1 - 0.0093 16.0 6.6 0.0093 16.0 6.6 4.6 3 1 2 5 5 4 2 Protein of unknown function (DUF1043) DUF2730 PF10805.8 EFE37401.1 - 0.021 14.9 9.6 3.7 7.7 0.1 5.1 3 2 1 4 4 4 0 Protein of unknown function (DUF2730) DUF2968 PF11180.8 EFE37401.1 - 0.059 13.0 0.3 0.059 13.0 0.3 4.2 5 1 1 6 6 6 0 Protein of unknown function (DUF2968) Atg14 PF10186.9 EFE37401.1 - 0.09 11.8 35.8 0.12 11.5 1.7 3.9 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4988 PF16378.5 EFE37401.1 - 0.12 12.1 8.3 6.9 6.3 0.1 4.4 3 1 1 4 4 4 0 Domain of unknown function DUF1759 PF03564.15 EFE37401.1 - 0.77 9.7 10.3 0.66 9.9 0.1 4.4 3 3 1 4 4 4 0 Protein of unknown function (DUF1759) BLOC1_2 PF10046.9 EFE37401.1 - 1 9.7 25.9 0.41 11.0 0.9 7.1 5 2 3 8 8 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 COG2 PF06148.11 EFE37401.1 - 1.2 9.2 17.6 1.9 8.6 0.6 4.8 4 1 1 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Cortex-I_coil PF09304.10 EFE37401.1 - 1.5 9.0 34.5 0.038 14.2 1.5 6.1 3 2 2 6 6 6 0 Cortexillin I, coiled coil Fib_alpha PF08702.10 EFE37401.1 - 2.3 8.4 38.2 3 8.0 1.2 6.0 2 2 3 6 6 6 0 Fibrinogen alpha/beta chain family WXG100 PF06013.12 EFE37401.1 - 2.9 8.2 15.5 7.4 6.9 0.6 6.2 5 2 2 7 7 7 0 Proteins of 100 residues with WXG DUF2205 PF10224.9 EFE37401.1 - 5.1 7.2 13.5 2 8.5 1.1 5.0 4 2 1 5 5 5 0 Short coiled-coil protein HrpB7 PF09486.10 EFE37401.1 - 6.2 7.2 18.7 0.17 12.2 2.6 3.9 4 0 0 4 4 4 0 Bacterial type III secretion protein (HrpB7) DUF4407 PF14362.6 EFE37401.1 - 6.3 6.1 33.2 49 3.1 14.4 4.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) Snapin_Pallidin PF14712.6 EFE37401.1 - 6.6 7.2 32.3 0.61 10.5 5.1 6.1 4 2 3 7 7 6 0 Snapin/Pallidin Phasin PF05597.11 EFE37401.1 - 6.9 6.7 23.6 0.96 9.5 1.0 5.2 4 1 1 5 5 5 0 Poly(hydroxyalcanoate) granule associated protein (phasin) TIP49 PF06068.13 EFE37402.1 - 3.1e-153 510.1 1.4 4.7e-153 509.5 1.4 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EFE37402.1 - 2.2e-21 75.8 0.8 7.6e-21 74.0 0.2 2.3 3 0 0 3 3 3 1 TIP49 AAA-lid domain AAA PF00004.29 EFE37402.1 - 6.2e-08 33.1 0.1 8.8e-05 22.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFE37402.1 - 1.9e-07 31.0 0.5 0.0002 21.2 0.1 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFE37402.1 - 2e-05 25.0 0.1 5.9e-05 23.5 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain DnaB_C PF03796.15 EFE37402.1 - 4.8e-05 22.8 0.6 8.7e-05 22.0 0.6 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Mg_chelatase PF01078.21 EFE37402.1 - 0.002 17.6 0.8 0.026 13.9 0.3 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFE37402.1 - 0.0079 16.2 0.1 0.61 10.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFE37402.1 - 0.014 15.6 0.0 0.96 9.7 0.0 2.4 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFE37402.1 - 0.024 14.3 0.0 8.6 6.0 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 EFE37402.1 - 0.049 14.0 1.6 1.7 8.9 1.6 2.4 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFE37402.1 - 0.052 13.1 0.1 0.099 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFE37402.1 - 0.067 13.3 0.1 0.26 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EFE37402.1 - 0.088 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 EFE37402.1 - 0.12 11.9 0.2 0.48 9.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region GYF PF02213.16 EFE37403.1 - 1.3e-07 31.2 1.2 3.1e-07 30.0 1.2 1.7 1 0 0 1 1 1 1 GYF domain UFD1 PF03152.14 EFE37404.1 - 4.8e-64 215.0 0.1 1.6e-62 210.0 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 ORC6 PF05460.13 EFE37405.1 - 0.033 13.4 3.2 0.04 13.2 3.2 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF1299 PF06975.11 EFE37405.1 - 0.036 14.1 2.6 0.083 13.0 2.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1299) DUF4366 PF14283.6 EFE37407.1 - 0.043 13.9 0.2 0.25 11.4 0.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) Apt1 PF10351.9 EFE37407.1 - 0.086 11.7 1.9 0.092 11.6 1.9 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 EFE37407.1 - 0.24 10.6 10.0 0.27 10.4 10.0 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein AMP-binding PF00501.28 EFE37409.1 - 0.13 10.8 0.8 0.14 10.7 0.8 1.0 1 0 0 1 1 1 0 AMP-binding enzyme Coilin_N PF15862.5 EFE37409.1 - 0.32 10.8 6.5 0.39 10.5 6.5 1.2 1 0 0 1 1 1 0 Coilin N-terminus Ribosomal_60s PF00428.19 EFE37409.1 - 0.65 10.6 15.1 16 6.2 15.1 2.0 1 1 0 1 1 1 0 60s Acidic ribosomal protein DUF3537 PF12056.8 EFE37409.1 - 0.66 8.7 3.0 0.77 8.5 3.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) TMEM171 PF15471.6 EFE37410.1 - 6.5 5.6 10.0 9.2 5.2 10.0 1.3 1 0 0 1 1 1 0 Transmembrane protein family 171 ORC6 PF05460.13 EFE37413.1 - 0.0073 15.6 6.0 0.009 15.3 6.0 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Abp2 PF09441.10 EFE37414.1 - 8.3e-86 286.4 0.1 1.6e-85 285.4 0.1 1.4 1 0 0 1 1 1 1 ARS binding protein 2 WW PF00397.26 EFE37417.1 - 3.6e-10 39.7 2.5 7.8e-10 38.7 2.5 1.6 1 0 0 1 1 1 1 WW domain DS PF01916.17 EFE37418.1 - 1.7e-129 431.2 0.0 2e-129 431.0 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase UCH PF00443.29 EFE37419.1 - 1.9e-10 40.7 0.0 3.7e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C3HC4_3 PF13920.6 EFE37419.1 - 3.2e-10 39.7 11.8 5.3e-10 39.0 11.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MORN PF02493.20 EFE37419.1 - 3.6e-06 26.5 23.6 0.025 14.5 4.8 4.6 4 0 0 4 4 4 3 MORN repeat Prok-RING_4 PF14447.6 EFE37419.1 - 0.0097 15.8 10.6 0.019 14.8 10.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFE37419.1 - 0.61 10.1 12.4 1.2 9.2 12.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Pkinase PF00069.25 EFE37420.1 - 5.1e-25 88.3 0.0 6.8e-24 84.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37420.1 - 1.6e-14 53.9 0.0 2.4e-13 50.0 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EFE37420.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EFE37420.1 - 0.052 12.3 0.1 0.098 11.4 0.1 1.3 1 1 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 EFE37420.1 - 0.095 12.3 0.0 0.26 10.8 0.0 1.6 1 1 0 1 1 1 0 RIO1 family Abhydrolase_1 PF00561.20 EFE37422.1 - 2.2e-11 43.9 2.8 2.3e-10 40.6 2.8 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE37422.1 - 6.7e-09 36.7 1.7 9e-09 36.3 1.7 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family HsbA PF12296.8 EFE37423.1 - 1.6e-28 99.6 6.3 1.6e-28 99.6 6.3 2.2 2 1 0 2 2 2 1 Hydrophobic surface binding protein A MF_alpha_N PF05436.11 EFE37423.1 - 0.12 12.3 2.2 0.12 12.3 0.4 2.0 2 0 0 2 2 2 0 Mating factor alpha precursor N-terminus Talin_middle PF09141.10 EFE37423.1 - 0.19 11.8 5.9 1.1 9.2 5.9 2.0 1 1 0 1 1 1 0 Talin, middle domain PIG-P PF08510.12 EFE37424.1 - 3e-53 178.9 0.9 3e-53 178.9 0.9 1.8 2 0 0 2 2 2 1 PIG-P DPM2 PF07297.12 EFE37424.1 - 0.012 15.8 7.8 0.021 15.1 7.8 1.2 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) BUD22 PF09073.10 EFE37424.1 - 0.11 11.8 4.5 0.15 11.4 4.5 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EFE37424.1 - 0.13 11.7 2.9 0.16 11.3 2.9 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EFE37424.1 - 0.21 9.9 0.0 0.29 9.4 0.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Phage_holin_3_6 PF07332.11 EFE37424.1 - 0.29 11.2 0.1 0.45 10.6 0.1 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III XPA_C PF05181.12 EFE37425.1 - 2.6e-26 91.3 2.3 5.6e-26 90.3 2.3 1.6 1 0 0 1 1 1 1 XPA protein C-terminus YhfH PF14149.6 EFE37425.1 - 0.016 15.2 4.2 0.89 9.6 0.2 2.6 2 0 0 2 2 2 0 YhfH-like protein ADD_DNMT3 PF17980.1 EFE37425.1 - 0.4 10.7 3.5 0.16 11.9 0.6 1.8 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 Ribosomal_L32e PF01655.18 EFE37425.1 - 0.41 11.1 2.4 0.46 10.9 0.5 1.9 2 0 0 2 2 2 0 Ribosomal protein L32 MAS20 PF02064.15 EFE37425.1 - 2.3 8.3 5.3 0.52 10.4 1.6 1.8 2 0 0 2 2 2 0 MAS20 protein import receptor Striatin PF08232.12 EFE37426.1 - 1.3e-46 159.0 4.7 1.3e-46 159.0 4.7 2.7 2 1 0 2 2 2 1 Striatin family WD40 PF00400.32 EFE37426.1 - 5e-25 87.3 22.9 2.4e-05 25.0 0.4 7.9 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE37426.1 - 0.00013 22.2 0.0 5.3 7.4 0.0 4.5 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFE37426.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EFE37426.1 - 0.14 10.6 0.0 0.31 9.5 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain Blt1 PF12754.7 EFE37427.1 - 4.8e-57 192.5 0.2 6.3e-57 192.1 0.2 1.2 1 0 0 1 1 1 1 Blt1 N-terminal domain Blt1_C PF17183.4 EFE37427.1 - 0.008 15.7 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 Get5 carboxyl domain DUF2340 PF10209.9 EFE37427.1 - 0.14 12.6 0.0 0.22 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) Methyltr_RsmB-F PF01189.17 EFE37428.1 - 2.6e-73 246.0 0.0 4e-73 245.3 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EFE37428.1 - 3.9e-07 30.5 0.0 1.4e-06 28.7 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EFE37428.1 - 0.041 14.0 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF4717 PF15838.5 EFE37428.1 - 0.18 11.9 3.0 0.5 10.4 3.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4717) EamA PF00892.20 EFE37429.1 - 1.9e-05 24.8 6.7 1.9e-05 24.8 6.7 2.2 2 0 0 2 2 2 2 EamA-like transporter family PHO4 PF01384.20 EFE37429.1 - 0.64 9.0 13.3 0.24 10.4 6.8 2.3 1 1 1 2 2 2 0 Phosphate transporter family DUF2431 PF10354.9 EFE37430.1 - 1.6e-60 204.2 0.0 3e-60 203.3 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) CLTH PF10607.9 EFE37431.1 - 1.7e-35 122.1 0.4 3e-35 121.3 0.1 1.6 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain DUF5398 PF17376.2 EFE37431.1 - 0.027 15.1 0.6 4.8 7.9 0.0 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5398) INCA1 PF15142.6 EFE37431.1 - 0.054 13.5 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 INCA1 SKA2 PF16740.5 EFE37431.1 - 0.23 11.2 3.9 0.11 12.2 0.6 2.2 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 DKCLD PF08068.12 EFE37432.1 - 1.1e-33 115.1 0.2 2.6e-32 110.7 0.3 2.5 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EFE37432.1 - 3.9e-23 81.4 1.5 7.1e-23 80.5 1.5 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EFE37432.1 - 6.3e-23 81.8 0.2 6e-20 72.1 0.2 3.4 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EFE37432.1 - 7.7e-21 73.8 1.3 1.5e-20 72.9 1.3 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EFE37432.1 - 0.0049 17.1 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain DUF4407 PF14362.6 EFE37432.1 - 1.5 8.1 11.4 2.8 7.2 11.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DER1 PF04511.15 EFE37433.1 - 1.7e-18 67.2 2.7 3.1e-09 37.0 0.4 2.1 2 0 0 2 2 2 2 Der1-like family Rhomboid PF01694.22 EFE37433.1 - 0.015 15.3 0.5 0.015 15.3 0.5 2.1 1 1 0 2 2 2 0 Rhomboid family Abhydrolase_3 PF07859.13 EFE37434.1 - 2.8e-44 151.5 0.0 1.3e-42 146.1 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFE37434.1 - 1.1e-07 31.1 0.3 7.1e-07 28.5 0.3 1.8 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.9 EFE37434.1 - 0.11 12.0 0.1 2.5 7.5 0.1 2.1 2 0 0 2 2 2 0 Esterase PHB depolymerase MaoC_dehydratas PF01575.19 EFE37435.1 - 0.0014 18.2 0.0 0.0022 17.5 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain PDT PF00800.18 EFE37436.1 - 4.1e-60 202.7 0.1 5.5e-60 202.3 0.1 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 EFE37436.1 - 6.6e-06 25.8 0.0 2.5e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 ACT domain eRF1_2 PF03464.15 EFE37437.1 - 1.1e-46 158.4 0.0 1.9e-46 157.7 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EFE37437.1 - 5.4e-39 133.2 0.2 1.1e-38 132.1 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EFE37437.1 - 1.8e-21 76.5 0.0 3.2e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EFE37437.1 - 5e-10 39.8 0.0 9.7e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EFE37437.1 - 9.8e-09 35.6 0.1 1.6e-08 34.9 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor Bmt2 PF11968.8 EFE37438.1 - 2.4e-89 298.9 0.0 2.9e-89 298.7 0.0 1.0 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 EFE37438.1 - 0.077 12.8 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_L23 PF00276.20 EFE37439.1 - 3.6e-13 49.7 0.3 3.6e-13 49.7 0.3 1.5 2 0 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 EFE37439.1 - 0.00052 20.2 3.0 0.00052 20.2 3.0 2.8 1 1 2 3 3 3 2 Ribosomal protein L23, N-terminal domain DUF3326 PF11805.8 EFE37439.1 - 0.085 11.7 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3326) Forkhead PF00250.18 EFE37440.1 - 8.9e-34 115.6 0.0 1.6e-33 114.8 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain G10 PF01125.17 EFE37441.1 - 1e-60 203.7 2.6 1.4e-60 203.3 2.6 1.2 1 0 0 1 1 1 1 G10 protein AA_kinase PF00696.28 EFE37442.1 - 2e-37 129.1 0.1 3.4e-37 128.3 0.1 1.4 1 0 0 1 1 1 1 Amino acid kinase family ACT_7 PF13840.6 EFE37442.1 - 4.4e-13 48.8 1.1 6.4e-11 41.9 0.1 2.6 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 EFE37442.1 - 1.1e-11 44.3 0.1 8.1e-09 35.1 0.1 3.0 3 0 0 3 3 3 2 ACT domain Peptidase_C78 PF07910.13 EFE37443.1 - 5.8e-36 124.0 0.3 7.4e-32 110.6 0.1 2.2 1 1 1 2 2 2 2 Peptidase family C78 zf-Di19 PF05605.12 EFE37443.1 - 0.0004 20.6 3.0 0.044 14.1 1.0 2.5 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 EFE37443.1 - 0.0025 17.4 0.0 0.006 16.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger zf-H2C2_5 PF13909.6 EFE37443.1 - 0.15 11.9 0.5 0.33 10.7 0.5 1.6 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 EFE37443.1 - 0.7 10.9 3.7 4.7 8.3 1.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger AAA_18 PF13238.6 EFE37444.1 - 3.6e-12 47.0 0.7 3.1e-11 43.9 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 EFE37444.1 - 3.2e-05 24.4 0.4 0.00018 21.9 0.1 2.1 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 EFE37444.1 - 0.00039 20.9 0.0 0.00073 20.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EFE37444.1 - 0.0012 19.1 1.0 0.003 17.8 1.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFE37444.1 - 0.0016 18.8 0.2 0.0025 18.1 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFE37444.1 - 0.0044 17.4 0.1 0.009 16.4 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 EFE37444.1 - 0.0045 16.9 0.1 0.014 15.3 0.0 1.8 2 0 0 2 2 2 1 NTPase KTI12 PF08433.10 EFE37444.1 - 0.0065 15.9 0.0 0.017 14.6 0.0 1.7 2 0 0 2 2 2 1 Chromatin associated protein KTI12 ADK PF00406.22 EFE37444.1 - 0.0075 16.4 0.2 0.042 13.9 0.0 2.1 1 1 1 2 2 2 1 Adenylate kinase AAA_14 PF13173.6 EFE37444.1 - 0.0086 16.1 0.2 0.021 14.9 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFE37444.1 - 0.0094 16.1 0.0 0.014 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 EFE37444.1 - 0.013 15.8 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RNA_helicase PF00910.22 EFE37444.1 - 0.03 14.7 0.0 0.05 14.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EFE37444.1 - 0.061 13.2 0.1 0.51 10.2 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 EFE37444.1 - 0.12 11.9 0.0 0.25 10.8 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 EFE37444.1 - 0.12 11.7 0.7 0.24 10.7 0.2 1.8 1 1 1 2 2 2 0 KaiC AAA_3 PF07726.11 EFE37444.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EFE37444.1 - 0.15 12.4 0.2 0.24 11.7 0.2 1.6 1 1 0 1 1 1 0 AAA domain Ham1p_like PF01725.16 EFE37445.1 - 1e-32 113.6 0.0 1.2e-32 113.4 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Myosin_head PF00063.21 EFE37446.1 - 2.5e-263 875.3 2.6 3.6e-263 874.8 2.6 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 EFE37446.1 - 3.8e-13 49.6 4.5 3.9e-13 49.6 0.0 3.3 3 1 1 4 4 3 1 DIL domain IQ PF00612.27 EFE37446.1 - 1.6e-11 42.9 32.7 3.8e-05 23.1 0.6 6.8 6 0 0 6 6 6 3 IQ calmodulin-binding motif GAS PF13851.6 EFE37446.1 - 0.00046 19.6 13.6 0.00046 19.6 13.6 2.7 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding AAA_16 PF13191.6 EFE37446.1 - 0.003 17.9 0.0 0.013 15.9 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain Myosin_N PF02736.19 EFE37446.1 - 0.0032 17.3 3.3 0.0082 15.9 3.3 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Spc7 PF08317.11 EFE37446.1 - 0.0036 16.2 20.5 0.0042 16.0 19.0 1.8 1 1 0 1 1 1 1 Spc7 kinetochore protein AAA_22 PF13401.6 EFE37446.1 - 0.0098 16.2 0.1 0.0098 16.2 0.1 2.8 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFE37446.1 - 0.018 14.1 0.0 0.04 13.0 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein CALCOCO1 PF07888.11 EFE37446.1 - 0.042 12.7 19.3 0.094 11.6 19.3 1.5 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like EzrA PF06160.12 EFE37446.1 - 0.064 11.4 16.0 0.39 8.8 2.7 2.4 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA RNA_helicase PF00910.22 EFE37446.1 - 0.091 13.2 0.0 0.37 11.2 0.0 2.1 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EFE37446.1 - 0.11 12.5 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fez1 PF06818.15 EFE37446.1 - 0.32 11.4 19.3 1.6 9.1 19.4 2.1 1 1 0 1 1 1 0 Fez1 KASH_CCD PF14662.6 EFE37446.1 - 0.85 9.4 23.5 0.31 10.9 19.2 2.3 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Baculo_PEP_C PF04513.12 EFE37446.1 - 0.95 9.5 10.5 0.33 11.0 5.2 2.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.11 EFE37446.1 - 1.9 9.0 10.9 1.3 9.5 0.1 3.9 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.12 EFE37446.1 - 9.7 6.3 27.7 0.15 12.1 4.2 3.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein NAP PF00956.18 EFE37447.1 - 1.2e-98 329.6 7.6 1.2e-98 329.6 7.6 1.6 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Sporozoite_P67 PF05642.11 EFE37447.1 - 7.3 4.5 9.1 23 2.9 0.0 2.2 2 0 0 2 2 2 0 Sporozoite P67 surface antigen HhH-GPD PF00730.25 EFE37448.1 - 2.2e-07 31.3 0.0 2.5e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DUF4332 PF14229.6 EFE37448.1 - 0.098 12.9 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Fasciclin PF02469.22 EFE37449.1 - 2.6e-32 111.8 0.1 3.7e-17 62.7 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain G_glu_transpept PF01019.21 EFE37450.1 - 6.5e-154 513.5 0.0 7.3e-154 513.3 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase RasGEF PF00617.19 EFE37451.1 - 6.1e-51 173.1 0.5 1.3e-50 172.1 0.5 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFE37451.1 - 1.9e-14 53.7 0.0 6.3e-14 52.1 0.0 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_9 PF14604.6 EFE37451.1 - 8e-07 28.8 0.1 2.2e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EFE37451.1 - 2.6e-05 23.7 0.0 7.3e-05 22.3 0.0 1.9 1 0 0 1 1 1 1 SH3 domain HATPase_c_3 PF13589.6 EFE37452.1 - 1.3e-19 70.4 0.0 2.4e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 EFE37452.1 - 2.6e-10 40.2 0.0 1.4e-09 37.9 0.0 2.0 2 0 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c PF02518.26 EFE37452.1 - 2.6e-08 34.4 0.1 5e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SLATT_fungal PF18142.1 EFE37454.1 - 1.4e-34 118.7 0.0 1.9e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain CEP63 PF17045.5 EFE37454.1 - 0.042 13.8 0.4 0.06 13.3 0.4 1.2 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa Fungal_trans_2 PF11951.8 EFE37455.1 - 0.00021 20.2 4.0 0.0012 17.8 0.7 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain MBOAT_2 PF13813.6 EFE37456.1 - 3.3e-12 46.5 6.2 3.6e-12 46.4 3.9 2.3 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family RTA1 PF04479.13 EFE37459.1 - 2.3e-58 197.2 11.5 3.8e-58 196.5 11.5 1.3 1 0 0 1 1 1 1 RTA1 like protein DUF1349 PF07081.11 EFE37460.1 - 5.5e-30 104.4 0.0 2.2e-29 102.5 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) MFS_1 PF07690.16 EFE37461.1 - 1.2e-21 77.0 39.7 3.6e-20 72.2 39.7 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TMEM100 PF16311.5 EFE37461.1 - 0.68 9.5 3.2 4.9 6.8 0.7 2.7 2 0 0 2 2 2 0 Transmembrane protein 100 DUF2530 PF10745.9 EFE37461.1 - 7.8 6.8 8.3 1.7 8.9 1.2 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF2530) p450 PF00067.22 EFE37462.1 - 7.4e-34 117.3 0.0 8.3e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 VWA PF00092.28 EFE37463.1 - 5.2e-17 62.6 0.1 7.6e-17 62.1 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFE37463.1 - 5.3e-14 52.8 0.0 7.7e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFE37463.1 - 1.7e-06 28.1 0.0 9.8e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFE37463.1 - 0.049 13.0 0.0 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein Vint PF14623.6 EFE37464.1 - 4.8e-60 202.2 0.0 8.8e-60 201.3 0.0 1.4 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.6 EFE37464.1 - 4.3e-08 33.2 0.0 0.00015 21.8 0.0 2.5 1 1 1 2 2 2 2 VWA / Hh protein intein-like ABC_membrane PF00664.23 EFE37465.1 - 3.6e-89 299.1 22.1 1.2e-49 169.4 10.4 3.1 2 1 1 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE37465.1 - 6.5e-67 224.3 0.0 9.7e-33 113.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFE37465.1 - 3.5e-13 49.5 0.4 0.00018 21.1 0.0 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFE37465.1 - 6.7e-07 29.6 0.3 0.089 13.1 0.0 3.3 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EFE37465.1 - 3e-06 26.9 4.4 0.0013 18.4 0.1 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFE37465.1 - 6.5e-06 26.2 0.2 0.11 12.3 0.0 2.9 3 0 0 3 3 2 2 RsgA GTPase AAA_16 PF13191.6 EFE37465.1 - 7.4e-06 26.4 2.2 0.17 12.2 0.2 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EFE37465.1 - 1.5e-05 25.0 0.2 0.29 10.9 0.0 3.8 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EFE37465.1 - 6.6e-05 23.5 0.0 0.15 12.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EFE37465.1 - 9.2e-05 22.2 0.8 0.69 9.6 0.0 3.1 3 1 0 3 3 2 2 AAA domain ABC_ATPase PF09818.9 EFE37465.1 - 0.00021 20.2 0.4 0.77 8.5 0.0 3.2 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_15 PF13175.6 EFE37465.1 - 0.00042 20.2 0.1 0.23 11.1 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 EFE37465.1 - 0.00046 19.8 0.0 0.21 11.1 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_23 PF13476.6 EFE37465.1 - 0.00073 20.1 0.4 0.52 10.8 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFE37465.1 - 0.00086 19.3 0.4 0.4 10.7 0.0 3.4 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EFE37465.1 - 0.0013 18.3 0.6 0.51 9.9 0.0 3.0 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 EFE37465.1 - 0.0016 18.9 1.5 1.6 9.1 0.0 3.8 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFE37465.1 - 0.0022 18.0 0.0 0.069 13.1 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain SRP54 PF00448.22 EFE37465.1 - 0.0027 17.4 0.1 2.7 7.6 0.0 2.5 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EFE37465.1 - 0.0028 17.0 0.0 0.19 11.0 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 EFE37465.1 - 0.0056 16.8 0.2 4.7 7.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFE37465.1 - 0.012 15.3 0.1 1 9.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFE37465.1 - 0.019 15.2 1.8 4.2 7.6 0.0 2.9 3 0 0 3 3 2 0 AAA domain SbcCD_C PF13558.6 EFE37465.1 - 0.027 14.7 3.9 1.3 9.3 0.8 3.7 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 EFE37465.1 - 0.049 12.8 0.0 6 5.9 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit ATP-synt_ab PF00006.25 EFE37465.1 - 0.062 12.9 0.4 8.1 6.0 0.0 3.8 4 1 0 4 4 4 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_14 PF13173.6 EFE37465.1 - 0.063 13.3 0.0 15 5.6 0.0 3.6 4 0 0 4 4 4 0 AAA domain PRK PF00485.18 EFE37465.1 - 0.097 12.4 0.2 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EFE37465.1 - 0.1 11.8 0.3 6.1 6.0 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain MMR_HSR1 PF01926.23 EFE37465.1 - 0.11 12.6 0.1 30 4.7 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EFE37465.1 - 0.13 12.6 0.6 8.6 6.8 0.0 3.0 3 0 0 3 3 3 0 RNA helicase AAA_17 PF13207.6 EFE37465.1 - 0.16 12.4 0.7 15 6.0 0.0 3.3 3 0 0 3 3 2 0 AAA domain MDM10 PF12519.8 EFE37466.1 - 5e-115 385.0 1.0 2.2e-96 323.5 0.4 2.0 1 1 1 2 2 2 2 Mitochondrial distribution and morphology protein 10 TIM PF00121.18 EFE37467.1 - 2.9e-89 298.6 0.4 3.3e-89 298.5 0.4 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase PhyH PF05721.13 EFE37468.1 - 1.1e-32 114.0 0.0 1.4e-32 113.7 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Imm41 PF15592.6 EFE37468.1 - 0.075 13.4 0.0 0.54 10.6 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 41 MFS_1 PF07690.16 EFE37469.1 - 2.2e-16 59.8 13.1 2.2e-16 59.8 13.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2423 PF10338.9 EFE37469.1 - 0.085 13.1 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2423) Amidase PF01425.21 EFE37470.1 - 1.5e-76 258.2 0.0 2.6e-76 257.4 0.0 1.4 1 1 0 1 1 1 1 Amidase DUF4185 PF13810.6 EFE37471.1 - 0.00033 20.0 0.2 0.00047 19.5 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) BMC PF00936.19 EFE37471.1 - 0.15 12.0 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 BMC domain RRM_1 PF00076.22 EFE37472.1 - 0.00033 20.4 0.0 0.00051 19.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 EFE37472.1 - 0.72 9.8 9.8 0.12 12.3 4.8 2.1 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) UDPGP PF01704.18 EFE37474.1 - 2.1e-189 629.5 0.0 2.4e-189 629.3 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase PilO PF04350.13 EFE37474.1 - 0.062 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Pilus assembly protein, PilO NYN_YacP PF05991.11 EFE37475.1 - 0.075 13.0 0.6 0.12 12.3 0.6 1.2 1 0 0 1 1 1 0 YacP-like NYN domain RRM_1 PF00076.22 EFE37476.1 - 1.1e-16 60.3 0.0 1.7e-11 43.7 0.0 3.0 2 2 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EFE37476.1 - 0.0063 16.6 0.0 0.34 11.0 0.0 2.5 2 0 0 2 2 2 1 Limkain b1 IATP PF04568.12 EFE37476.1 - 2.9 8.4 5.9 7.6 7.0 5.9 1.8 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP MFS_1 PF07690.16 EFE37477.1 - 2.7e-07 29.9 57.1 0.0008 18.4 28.0 3.7 2 1 1 4 4 4 3 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE37477.1 - 0.00025 20.0 12.1 0.00025 20.0 12.1 3.3 2 1 1 3 3 3 3 Sugar (and other) transporter TANGO2 PF05742.12 EFE37478.1 - 1.9e-60 205.1 0.0 2.3e-60 204.8 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 BPL_N PF09825.9 EFE37479.1 - 1.8e-133 445.3 0.0 7.2e-133 443.3 0.0 1.8 1 1 1 2 2 2 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EFE37479.1 - 5.9e-24 84.4 0.0 1e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EFE37479.1 - 5.5e-06 26.2 0.0 1.3e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain Mgm101p PF06420.12 EFE37480.1 - 4.3e-87 290.0 0.0 5.9e-87 289.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 zf-RING_2 PF13639.6 EFE37481.1 - 1.9e-13 50.5 5.4 3.1e-13 49.8 5.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFE37481.1 - 2e-10 40.2 1.6 3.5e-10 39.4 1.6 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFE37481.1 - 8.3e-09 35.2 5.0 1.4e-08 34.5 5.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE37481.1 - 6.9e-08 32.2 2.1 1.2e-07 31.5 2.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFE37481.1 - 1.5e-06 28.4 5.7 4.7e-06 26.8 5.7 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EFE37481.1 - 8.8e-06 25.5 6.4 0.00013 21.8 6.2 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFE37481.1 - 3.5e-05 23.7 1.7 6.7e-05 22.8 1.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFE37481.1 - 6.6e-05 22.7 1.9 0.00014 21.6 1.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE37481.1 - 0.00012 22.0 4.3 0.00027 20.9 4.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EFE37481.1 - 0.00044 20.2 1.5 0.00087 19.3 1.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFE37481.1 - 0.014 15.2 2.9 0.027 14.3 2.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EFE37481.1 - 0.1 12.9 1.1 0.22 11.9 1.1 1.6 1 0 0 1 1 1 0 RING-like domain Zn_ribbon_17 PF17120.5 EFE37481.1 - 0.2 11.3 1.2 0.35 10.5 1.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 EFE37481.1 - 0.26 11.2 3.8 0.35 10.8 1.4 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FANCL_C PF11793.8 EFE37481.1 - 0.62 10.3 3.8 3.8 7.8 3.8 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 EFE37481.1 - 0.73 9.8 2.7 1.6 8.7 2.7 1.7 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.6 EFE37481.1 - 0.85 9.8 5.1 1.9 8.7 5.1 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING NLPC_P60 PF00877.19 EFE37482.1 - 1.3e-07 31.5 0.0 1.9e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 NlpC/P60 family Phage_lysozyme PF00959.19 EFE37483.1 - 5e-11 43.0 0.0 6.7e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Phage lysozyme Stanniocalcin PF03298.13 EFE37484.1 - 0.16 11.3 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 Stanniocalcin family MS_channel PF00924.18 EFE37486.1 - 9.7e-19 67.7 0.5 1.9e-18 66.7 0.5 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_7 PF13499.6 EFE37486.1 - 0.14 12.6 0.1 0.62 10.6 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 EFE37486.1 - 0.16 11.6 1.4 0.29 10.8 0.2 2.1 2 0 0 2 2 2 0 EF hand Pkinase PF00069.25 EFE37487.1 - 5.6e-23 81.6 0.0 8.3e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37487.1 - 7.2e-05 22.2 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFE37487.1 - 0.0073 15.7 0.0 0.01 15.2 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFE37487.1 - 0.079 11.7 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase EcKinase PF02958.20 EFE37487.1 - 0.24 10.6 0.0 0.4 9.9 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Aminotran_1_2 PF00155.21 EFE37489.1 - 1.7e-78 264.3 0.0 2.1e-78 264.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II UL17 PF17640.2 EFE37490.1 - 0.035 14.1 1.0 0.083 12.9 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized UL17 Syntaxin-18_N PF10496.9 EFE37491.1 - 6.3e-10 39.2 0.4 4.9e-09 36.3 0.0 2.5 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 EFE37491.1 - 4.5e-06 26.6 0.2 1.3e-05 25.1 0.1 1.8 2 0 0 2 2 2 1 SNARE domain DUF1897 PF09005.10 EFE37491.1 - 5.1 6.7 5.9 20 4.8 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1897) TPR_1 PF00515.28 EFE37492.1 - 5.2e-14 51.4 6.9 3.1e-07 29.9 0.2 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFE37492.1 - 8.4e-14 50.5 5.6 1.4e-05 24.8 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFE37492.1 - 4.6e-10 39.7 0.1 1.2e-05 25.6 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat PB1 PF00564.24 EFE37492.1 - 2.2e-07 30.7 0.1 4.2e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 PB1 domain TPR_7 PF13176.6 EFE37492.1 - 8.4e-07 28.6 0.7 0.00027 20.7 0.1 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE37492.1 - 2e-06 27.4 3.9 7.8e-05 22.3 0.8 3.6 2 1 1 3 3 3 1 TPR repeat TPR_8 PF13181.6 EFE37492.1 - 7.4e-06 25.8 6.3 0.0012 18.9 0.1 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFE37492.1 - 3e-05 24.4 0.2 8.2 7.3 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFE37492.1 - 8.7e-05 23.1 1.5 0.033 14.8 0.5 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFE37492.1 - 0.0012 19.0 0.0 2.4 8.3 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFE37492.1 - 0.0057 16.9 0.2 0.36 11.3 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFE37492.1 - 0.0073 17.0 0.4 0.28 12.1 0.1 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFE37492.1 - 0.77 9.7 5.6 1 9.3 0.0 3.7 6 0 0 6 6 5 0 Tetratricopeptide repeat Sod_Cu PF00080.20 EFE37493.1 - 4.6e-07 30.1 0.0 5.5e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Pkinase PF00069.25 EFE37494.1 - 1.4e-61 208.2 0.0 3.2e-61 207.0 0.0 1.5 2 0 0 2 2 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37494.1 - 4.6e-26 91.6 0.0 7.5e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE37494.1 - 0.0037 16.6 0.0 0.0037 16.6 0.0 1.8 2 0 0 2 2 1 1 Kinase-like Kdo PF06293.14 EFE37494.1 - 0.037 13.4 0.1 0.064 12.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LCD1 PF09798.9 EFE37494.1 - 0.055 12.0 0.5 0.07 11.7 0.5 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Haspin_kinase PF12330.8 EFE37494.1 - 0.06 12.3 0.0 0.06 12.3 0.0 1.5 2 0 0 2 2 1 0 Haspin like kinase domain APH PF01636.23 EFE37494.1 - 0.24 11.3 0.1 0.24 11.3 0.1 2.0 2 0 0 2 2 1 0 Phosphotransferase enzyme family K1377 PF15352.6 EFE37494.1 - 0.86 7.8 10.9 1.1 7.4 10.9 1.1 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy MCM_bind PF09739.9 EFE37494.1 - 2.4 6.5 10.7 3.1 6.1 10.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Ndc1_Nup PF09531.10 EFE37494.1 - 3.1 6.4 5.4 4.5 5.8 5.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDC45 PF02724.14 EFE37494.1 - 3.9 5.6 8.0 5.6 5.1 8.0 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF1168 PF06658.12 EFE37494.1 - 4.9 7.0 18.3 9.4 6.1 18.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) U79_P34 PF03064.16 EFE37494.1 - 6.4 6.1 18.2 11 5.3 18.2 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 RXT2_N PF08595.11 EFE37495.1 - 0.42 10.6 9.3 1.1 9.2 2.2 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal AMP-binding PF00501.28 EFE37496.1 - 1.3e-217 722.4 0.0 9.3e-75 251.8 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EFE37496.1 - 7.3e-125 417.2 0.0 5e-47 160.6 0.0 5.5 5 1 0 5 5 5 4 Condensation domain PP-binding PF00550.25 EFE37496.1 - 1.1e-38 131.4 3.4 1.7e-11 44.3 0.0 5.1 5 0 0 5 5 5 3 Phosphopantetheine attachment site NAD_binding_4 PF07993.12 EFE37496.1 - 1.8e-33 115.8 0.0 4.2e-33 114.6 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EFE37496.1 - 3.8e-09 36.4 0.0 7.7e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 EFE37496.1 - 2.4e-05 25.2 0.0 0.78 10.8 0.0 3.8 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain AvrM_N PF18247.1 EFE37496.1 - 0.15 12.0 0.1 18 5.4 0.0 2.9 2 0 0 2 2 2 0 Flax-rust effector AvrM N-terminal domain Usp PF00582.26 EFE37497.1 - 2.8e-13 50.6 1.7 3.9e-07 30.7 0.1 2.6 1 1 1 2 2 2 2 Universal stress protein family Med27 PF11571.8 EFE37498.1 - 0.051 13.9 0.2 0.19 12.1 0.1 2.0 2 0 0 2 2 2 0 Mediator complex subunit 27 SpoIIIAH PF12685.7 EFE37499.1 - 0.00098 19.0 1.6 0.0013 18.6 1.6 1.3 1 0 0 1 1 1 1 SpoIIIAH-like protein MFMR_assoc PF16596.5 EFE37499.1 - 0.017 15.6 11.8 0.03 14.8 11.8 1.4 1 0 0 1 1 1 0 Disordered region downstream of MFMR Presenilin PF01080.17 EFE37499.1 - 0.023 13.5 0.3 0.034 12.9 0.3 1.4 1 0 0 1 1 1 0 Presenilin AAR2 PF05282.11 EFE37499.1 - 0.033 13.6 0.4 0.046 13.1 0.4 1.2 1 0 0 1 1 1 0 AAR2 protein NPR3 PF03666.13 EFE37499.1 - 0.043 12.6 0.9 0.058 12.2 0.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 EFE37499.1 - 0.15 10.6 4.8 0.16 10.5 4.8 1.1 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 EFE37499.1 - 0.69 8.7 8.2 0.95 8.2 8.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4834 PF16118.5 EFE37499.1 - 0.7 10.9 2.9 1.9 9.5 2.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) TraV PF09676.10 EFE37499.1 - 1.2 10.1 7.0 4.2 8.3 5.4 2.0 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) Zip PF02535.22 EFE37499.1 - 2 7.6 4.5 2.1 7.4 4.5 1.3 1 1 0 1 1 1 0 ZIP Zinc transporter SNF2_N PF00176.23 EFE37500.1 - 9.3e-67 225.2 0.0 1.6e-66 224.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE37500.1 - 4.8e-18 65.5 0.0 1e-17 64.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE37500.1 - 8.4e-06 25.9 0.0 2.3e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TFIIF_beta PF02270.15 EFE37500.1 - 0.0012 19.0 0.1 0.01 15.9 0.0 2.5 2 0 0 2 2 2 1 TFIIF, beta subunit HTH domain SPEG_u2 PF16650.5 EFE37500.1 - 0.016 15.3 0.5 0.057 13.6 0.5 1.9 1 0 0 1 1 1 0 Unstructured region on SPEG complex protein AAA_11 PF13086.6 EFE37500.1 - 3.9 7.2 0.0 3.9 7.2 0.0 3.7 5 0 0 5 5 5 0 AAA domain Pkinase PF00069.25 EFE37503.1 - 1.7e-38 132.5 2.2 4.3e-22 78.7 0.9 2.9 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37503.1 - 1.2e-14 54.3 8.2 1.3e-12 47.6 1.7 2.9 3 1 1 4 4 4 2 Protein tyrosine kinase RIO1 PF01163.22 EFE37503.1 - 0.026 14.1 0.3 0.09 12.4 0.4 1.8 1 1 0 1 1 1 0 RIO1 family APH PF01636.23 EFE37503.1 - 0.05 13.5 0.1 0.05 13.5 0.1 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family CYYR1 PF10873.8 EFE37503.1 - 8.8 6.8 11.0 24 5.4 11.0 1.7 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 eIF-3c_N PF05470.12 EFE37504.1 - 3.7e-168 560.5 28.1 1.5e-135 452.8 4.4 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EFE37504.1 - 7.8e-14 52.1 1.6 7.9e-12 45.6 0.1 3.8 2 1 1 3 3 3 1 PCI domain DASH_Ask1 PF08655.10 EFE37504.1 - 0.024 14.5 0.3 0.71 9.8 0.1 2.9 2 0 0 2 2 2 0 DASH complex subunit Ask1 CDC45 PF02724.14 EFE37504.1 - 1.6 7.0 18.3 2.4 6.4 18.3 1.2 1 0 0 1 1 1 0 CDC45-like protein EAP30 PF04157.16 EFE37505.1 - 1.3e-71 240.6 0.0 1.5e-71 240.5 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Ribosomal_L30_N PF08079.12 EFE37506.1 - 2.5e-18 66.1 1.3 4.6e-18 65.2 1.3 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EFE37506.1 - 1.8e-17 62.9 1.7 1.8e-17 62.9 1.7 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Tipalpha PF16753.5 EFE37506.1 - 0.059 13.2 0.1 0.18 11.6 0.1 1.8 1 1 1 2 2 2 0 TNF-alpha-Inducing protein of Helicobacter DNA_pol_B PF00136.21 EFE37507.1 - 1.1e-116 390.2 1.9 1.2e-116 390.1 0.6 1.7 2 0 0 2 2 2 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EFE37507.1 - 7.6e-68 227.9 1.3 1.1e-67 227.4 0.3 1.9 2 0 0 2 2 2 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EFE37507.1 - 2.1e-45 155.4 0.0 4.7e-45 154.2 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EFE37507.1 - 1.6e-24 85.8 10.5 1.6e-24 85.8 10.5 2.5 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 EFE37507.1 - 0.00073 18.5 0.0 0.0016 17.4 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral HSP70 PF00012.20 EFE37508.1 - 1.8e-263 875.2 16.4 2.1e-263 875.0 16.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFE37508.1 - 1.2e-14 53.9 6.4 8.2e-13 47.9 2.3 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EFE37508.1 - 9.4e-05 22.2 0.1 0.00028 20.7 0.1 1.9 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 EFE37508.1 - 0.041 13.1 6.9 0.1 11.8 0.1 3.3 3 1 1 4 4 4 0 StbA protein Scaffolding_pro PF11418.8 EFE37508.1 - 0.046 14.3 1.6 0.12 13.0 1.6 1.6 1 0 0 1 1 1 0 Phi29 scaffolding protein SMBP PF16785.5 EFE37508.1 - 0.098 12.9 4.3 0.093 13.0 1.4 2.3 2 0 0 2 2 2 0 Small metal-binding protein Histone_HNS PF00816.21 EFE37508.1 - 4.6 8.1 10.8 20 6.1 4.1 3.4 3 1 0 3 3 3 0 H-NS histone family FtsA PF14450.6 EFE37508.1 - 5.2 7.6 12.9 1.3 9.4 0.9 3.9 3 3 0 3 3 3 0 Cell division protein FtsA DUF2415 PF10313.9 EFE37509.1 - 9.4e-16 57.5 0.0 2.4e-15 56.2 0.0 1.8 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) CAP_N PF01213.19 EFE37509.1 - 3.1 7.2 9.3 6 6.3 9.3 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 EFE37509.1 - 4.6 7.3 7.1 12 6.0 7.1 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 PigN PF04987.14 EFE37510.1 - 0.0018 17.3 2.4 0.0018 17.3 2.4 2.1 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) DSHCT PF08148.12 EFE37511.1 - 2e-51 173.9 0.5 4.7e-51 172.7 0.5 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 EFE37511.1 - 7.5e-40 135.9 0.0 1.6e-39 134.8 0.0 1.6 1 0 0 1 1 1 1 Ski2 N-terminal region DEAD PF00270.29 EFE37511.1 - 5.4e-17 62.1 0.0 1.1e-16 61.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 EFE37511.1 - 3.6e-16 59.9 1.5 1.9e-15 57.6 1.5 2.2 1 1 0 1 1 1 1 rRNA-processing arch domain Helicase_C PF00271.31 EFE37511.1 - 7.6e-06 26.2 0.0 2.1e-05 24.8 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE37511.1 - 0.00024 21.1 0.0 0.00051 20.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit IBN_N PF03810.19 EFE37512.1 - 3.7e-15 55.6 0.0 1.9e-13 50.1 0.0 3.3 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.10 EFE37512.1 - 2.1e-06 26.8 0.0 4.4e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Cse1 HEAT_2 PF13646.6 EFE37512.1 - 0.00011 22.6 0.1 0.56 10.6 0.0 3.5 2 1 1 3 3 3 1 HEAT repeats GRIP PF01465.20 EFE37512.1 - 0.0014 18.4 0.0 0.012 15.5 0.0 2.7 1 1 1 2 2 2 1 GRIP domain Xpo1 PF08389.12 EFE37512.1 - 0.0028 17.7 0.9 0.04 14.0 0.0 3.2 3 0 0 3 3 3 1 Exportin 1-like protein CAS_CSE1 PF03378.15 EFE37512.1 - 0.004 15.7 0.3 0.048 12.1 0.1 2.6 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus RTP1_C1 PF10363.9 EFE37512.1 - 0.0095 16.1 0.1 0.16 12.2 0.1 2.8 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF2408 PF10303.9 EFE37512.1 - 0.11 13.1 0.2 2 9.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) HEAT_EZ PF13513.6 EFE37512.1 - 0.12 13.0 0.2 28 5.3 0.0 4.3 4 0 0 4 4 3 0 HEAT-like repeat Telomere_reg-2 PF10193.9 EFE37512.1 - 0.13 12.7 0.1 0.61 10.5 0.1 2.1 1 0 0 1 1 1 0 Telomere length regulation protein Vac14_Fab1_bd PF12755.7 EFE37512.1 - 0.25 12.0 0.9 1.9 9.1 0.0 3.0 3 0 0 3 3 2 0 Vacuolar 14 Fab1-binding region RRM_1 PF00076.22 EFE37513.1 - 5.8e-08 32.4 0.0 1.2e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFE37513.1 - 9.8e-06 25.5 0.0 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EFE37513.1 - 0.00071 19.4 0.0 0.0039 17.0 0.0 2.1 2 0 0 2 2 2 1 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EFE37513.1 - 0.091 13.0 0.5 0.9 9.7 0.1 2.3 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Ferlin_C PF16165.5 EFE37514.1 - 5 7.0 9.9 8.8 6.3 3.9 2.5 2 0 0 2 2 2 0 Ferlin C-terminus AP3D1 PF06375.11 EFE37514.1 - 8.9 6.5 26.2 0.44 10.8 15.5 3.1 3 1 0 3 3 3 0 AP-3 complex subunit delta-1 DbpA PF03880.15 EFE37515.1 - 0.0032 17.4 0.0 0.0064 16.5 0.0 1.5 1 0 0 1 1 1 1 DbpA RNA binding domain RRM_1 PF00076.22 EFE37515.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.16 EFE37516.1 - 1.3e-23 83.5 23.7 4.4e-22 78.5 8.5 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE37516.1 - 1.8e-08 33.7 5.0 1.8e-08 33.7 5.0 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_5 PF05631.14 EFE37516.1 - 0.0028 16.6 0.2 0.0051 15.8 0.2 1.4 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM Fungal_TACC PF12709.7 EFE37517.1 - 2.2e-10 40.9 22.7 1.3e-08 35.1 3.5 4.3 3 1 2 5 5 5 2 Fungal Transforming acidic coiled-coil (TACC) proteins DUF4407 PF14362.6 EFE37517.1 - 0.0062 15.9 25.7 0.019 14.3 7.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EFE37517.1 - 0.016 15.2 19.0 0.045 13.8 4.8 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 EFE37517.1 - 0.11 11.2 22.1 0.18 10.4 7.0 2.2 2 0 0 2 2 2 0 AAA domain MscS_porin PF12795.7 EFE37517.1 - 0.42 10.1 27.3 2.5 7.6 8.0 3.7 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain Z1 PF10593.9 EFE37517.1 - 0.52 9.8 9.2 1.1 8.8 1.2 2.6 2 1 0 2 2 2 0 Z1 domain DUF745 PF05335.13 EFE37517.1 - 0.98 9.1 30.2 0.04 13.6 13.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF745) DUF2959 PF11172.8 EFE37517.1 - 1.5 8.9 17.3 0.9 9.6 11.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF2959) Fib_alpha PF08702.10 EFE37517.1 - 2.3 8.4 12.3 2.2 8.5 0.5 3.8 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EFE37517.1 - 3.5 8.0 37.3 34 4.8 19.3 2.7 1 1 1 2 2 2 0 Fez1 GAS PF13851.6 EFE37517.1 - 4.2 6.7 32.7 1.3 8.3 11.8 2.9 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3209 PF11483.8 EFE37517.1 - 7.1 7.1 15.2 2.3 8.7 3.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3209) ADIP PF11559.8 EFE37517.1 - 8.2 6.5 30.6 2.1 8.4 4.5 4.3 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding DUF3450 PF11932.8 EFE37517.1 - 8.2 5.7 25.6 0.86 8.8 10.3 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) FAD_binding_3 PF01494.19 EFE37518.1 - 2.7e-11 43.3 0.1 9.6e-11 41.5 0.0 1.9 2 1 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EFE37518.1 - 2.8e-05 23.3 0.5 0.15 11.1 0.0 2.9 3 0 0 3 3 3 2 Lycopene cyclase protein DAO PF01266.24 EFE37518.1 - 0.00092 18.9 0.2 0.0044 16.6 0.1 1.9 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE37518.1 - 0.0061 16.8 0.4 0.084 13.1 0.1 2.8 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFE37518.1 - 0.008 16.2 0.0 0.26 11.3 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding DegT_DnrJ_EryC1 PF01041.17 EFE37518.1 - 0.095 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family SE PF08491.10 EFE37518.1 - 0.18 10.8 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase Fungal_trans PF04082.18 EFE37519.1 - 4.3e-30 104.7 0.6 8.1e-30 103.7 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE37519.1 - 0.0047 17.0 18.0 0.0082 16.2 18.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sof1 PF04158.14 EFE37519.1 - 0.045 14.0 0.5 0.14 12.5 0.5 1.8 1 0 0 1 1 1 0 Sof1-like domain MFS_1 PF07690.16 EFE37520.1 - 6.1e-15 55.0 31.4 6.1e-15 55.0 31.4 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EFE37520.1 - 2.5e-11 43.5 3.8 2.5e-11 43.5 3.8 2.1 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Amidohydro_1 PF01979.20 EFE37521.1 - 3e-16 59.7 0.0 1.2e-15 57.7 0.0 1.8 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFE37521.1 - 3.9e-13 49.7 1.4 6.5e-09 35.8 0.2 2.3 2 0 0 2 2 2 2 Amidohydrolase family GMC_oxred_N PF00732.19 EFE37522.1 - 9.7e-48 163.0 0.0 1.3e-47 162.6 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFE37522.1 - 9.1e-36 123.5 0.0 1.4e-35 123.0 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EFE37522.1 - 3.4e-05 23.1 0.0 5.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EFE37522.1 - 7.4e-05 22.9 0.1 0.00026 21.2 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFE37522.1 - 0.00013 21.2 0.0 0.14 11.2 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EFE37522.1 - 0.001 18.8 0.2 0.0033 17.1 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFE37522.1 - 0.004 16.4 0.0 0.0088 15.3 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE37522.1 - 0.008 16.7 0.2 0.71 10.5 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFE37522.1 - 0.015 14.1 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 EFE37522.1 - 0.04 13.1 0.1 0.54 9.5 0.0 2.4 3 0 0 3 3 3 0 Thi4 family FAD_oxidored PF12831.7 EFE37522.1 - 0.055 12.8 0.0 0.68 9.2 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Aldedh PF00171.22 EFE37523.1 - 1.6e-159 531.4 0.3 1.9e-159 531.1 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Wtap PF17098.5 EFE37523.1 - 0.0016 18.4 0.0 0.003 17.5 0.0 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family Glucosamine_iso PF01182.20 EFE37524.1 - 4.1e-12 46.5 0.0 6.7e-12 45.8 0.0 1.3 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Glyco_hydro_3 PF00933.21 EFE37525.1 - 1.1e-63 215.5 0.0 1.8e-63 214.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFE37525.1 - 7.3e-07 29.3 0.0 1.6e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_1 PF00583.25 EFE37525.1 - 1e-05 25.7 0.0 2.8e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFE37525.1 - 0.045 13.7 0.0 0.2 11.7 0.0 2.1 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_7 PF13508.7 EFE37525.1 - 0.045 14.2 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFE37525.1 - 0.062 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ribosomal_60s PF00428.19 EFE37525.1 - 0.17 12.5 10.7 0.99 10.0 1.4 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein NDT80_PhoG PF05224.12 EFE37527.1 - 1.9e-31 109.7 9.2 1.5e-20 74.2 0.0 3.9 4 0 0 4 4 4 2 NDT80 / PhoG like DNA-binding family TFIIA PF03153.13 EFE37527.1 - 2.6 8.0 41.5 2.9 7.8 23.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Hexokinase_2 PF03727.16 EFE37528.1 - 2.7e-54 184.1 0.0 5.1e-54 183.2 0.0 1.5 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EFE37528.1 - 2.7e-45 154.7 0.0 5.6e-45 153.7 0.0 1.5 2 0 0 2 2 2 1 Hexokinase Thioredox_DsbH PF03190.15 EFE37530.1 - 1.8e-39 135.3 0.0 3.1e-39 134.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 WD40 PF00400.32 EFE37531.1 - 1.4e-11 44.8 18.6 0.0038 18.0 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE37531.1 - 0.011 16.0 0.1 6.3 7.2 0.0 3.4 2 2 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 EFE37531.1 - 0.013 14.6 0.3 0.14 11.2 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1513) Nucleoporin_N PF08801.11 EFE37531.1 - 0.17 10.6 0.0 0.45 9.2 0.0 1.7 2 0 0 2 2 2 0 Nup133 N terminal like LSM14 PF12701.7 EFE37532.1 - 1.5e-20 73.0 0.0 2.8e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 EFE37532.1 - 1.8e-17 64.1 5.0 1.8e-17 64.1 5.0 3.5 2 2 1 3 3 3 1 FDF domain SM-ATX PF14438.6 EFE37532.1 - 0.16 12.1 0.1 0.52 10.5 0.0 1.8 2 0 0 2 2 2 0 Ataxin 2 SM domain TFIIA PF03153.13 EFE37532.1 - 0.87 9.5 41.9 0.086 12.8 31.9 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit GRP PF07172.11 EFE37532.1 - 1.1 9.9 26.7 9.2 7.0 1.0 2.9 2 0 0 2 2 2 0 Glycine rich protein family Sigma70_ner PF04546.13 EFE37533.1 - 0.03 14.2 3.4 0.044 13.7 3.4 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Sporozoite_P67 PF05642.11 EFE37533.1 - 0.059 11.5 2.2 0.066 11.3 2.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FA_desaturase PF00487.24 EFE37533.1 - 0.068 13.0 0.7 0.1 12.4 0.7 1.2 1 0 0 1 1 1 0 Fatty acid desaturase DUF1754 PF08555.10 EFE37533.1 - 0.069 13.9 5.5 0.12 13.2 5.5 1.4 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) TraP PF07296.11 EFE37533.1 - 0.16 11.2 0.6 0.25 10.5 0.6 1.3 1 0 0 1 1 1 0 TraP protein DNA_pol_phi PF04931.13 EFE37533.1 - 0.29 9.2 7.2 0.43 8.6 7.2 1.3 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EFE37533.1 - 1.4 8.2 10.0 1.9 7.7 10.0 1.1 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EFE37533.1 - 1.7 6.8 8.9 2.2 6.5 8.9 1.1 1 0 0 1 1 1 0 CDC45-like protein AIM3 PF17096.5 EFE37533.1 - 7.7 7.5 7.9 17 6.5 7.9 1.5 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 Glyco_transf_15 PF01793.16 EFE37534.1 - 1.1e-101 340.3 15.1 1.3e-101 340.2 15.1 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF4974 PF16344.5 EFE37534.1 - 0.18 11.8 0.3 0.77 9.8 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4974) GCP_N_terminal PF17681.1 EFE37535.1 - 6.6e-30 104.8 1.4 1.4e-29 103.8 0.2 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFE37535.1 - 2.6e-24 86.2 1.3 2.6e-24 86.2 1.3 2.3 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP5-Mod21 PF14609.6 EFE37535.1 - 4.6e-06 25.3 0.8 1.4e-05 23.7 0.2 2.0 2 1 0 2 2 2 1 gamma-Tubulin ring complex non-core subunit mod21 GATase_5 PF13507.6 EFE37536.1 - 1.8e-96 322.2 0.0 3e-96 321.5 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EFE37536.1 - 9.1e-39 133.1 0.6 2.2e-23 83.1 0.2 2.6 3 0 0 3 3 3 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EFE37536.1 - 3.4e-32 110.8 0.0 6.1e-32 110.0 0.0 1.4 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EFE37536.1 - 4.3e-21 75.2 0.0 8.7e-21 74.2 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain ALG11_N PF15924.5 EFE37537.1 - 1e-78 264.2 0.1 1.5e-78 263.7 0.1 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EFE37537.1 - 1.7e-18 66.7 0.0 4.2e-18 65.5 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFE37537.1 - 3e-07 30.9 0.0 2.8e-06 27.8 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFE37537.1 - 0.0036 17.3 0.0 0.0073 16.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase Family 4 HemY_N PF07219.13 EFE37537.1 - 0.019 15.1 0.1 0.069 13.4 0.1 2.0 1 0 0 1 1 1 0 HemY protein N-terminus 60KD_IMP PF02096.20 EFE37538.1 - 8.7e-17 61.5 0.5 6.9e-16 58.6 0.5 1.9 1 1 0 1 1 1 1 60Kd inner membrane protein PP2C PF00481.21 EFE37539.1 - 1.4e-41 142.8 0.0 2.3e-41 142.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EFE37539.1 - 0.00023 20.9 0.0 0.00039 20.1 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EFE37539.1 - 0.023 14.6 0.0 0.58 10.0 0.0 2.6 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) Baseplate_J PF04865.14 EFE37539.1 - 0.039 13.1 0.1 0.079 12.1 0.1 1.4 1 0 0 1 1 1 0 Baseplate J-like protein TetR_C_24 PF17932.1 EFE37539.1 - 0.44 10.8 1.4 1.2 9.4 0.3 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PPDFL PF15060.6 EFE37539.1 - 1.5 9.4 7.3 8.4 7.0 0.0 3.0 2 1 0 2 2 2 0 Differentiation and proliferation regulator Tcf25 PF04910.14 EFE37540.1 - 1.4e-49 169.1 0.6 1.7e-44 152.3 0.0 2.2 1 1 1 2 2 2 2 Transcriptional repressor TCF25 Stm1_N PF09598.10 EFE37540.1 - 0.014 16.2 3.1 0.047 14.5 3.1 1.9 1 0 0 1 1 1 0 Stm1 PQ-loop PF04193.14 EFE37541.1 - 1.6e-18 66.2 2.5 1.6e-18 66.2 2.5 2.6 3 0 0 3 3 3 1 PQ loop repeat Ribosomal_60s PF00428.19 EFE37542.1 - 1.3e-20 73.8 12.1 3.5e-16 59.5 9.6 2.1 2 0 0 2 2 2 2 60s Acidic ribosomal protein DUF2408 PF10303.9 EFE37543.1 - 3.8e-49 166.7 0.1 1e-28 100.6 0.0 5.1 3 2 1 4 4 4 4 Protein of unknown function (DUF2408) DUF2920 PF11144.8 EFE37543.1 - 0.1 11.7 0.1 28 3.7 0.0 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF2920) Snapin_Pallidin PF14712.6 EFE37543.1 - 0.15 12.5 1.3 4 7.9 0.1 3.1 3 0 0 3 3 3 0 Snapin/Pallidin Aconitase PF00330.20 EFE37544.1 - 1.3e-142 476.0 0.0 1.8e-142 475.6 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFE37544.1 - 7.8e-40 136.2 0.0 1.3e-39 135.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Importin_rep_4 PF18808.1 EFE37545.1 - 1.2e-32 112.1 2.6 3.9e-32 110.4 1.0 2.9 2 0 0 2 2 2 1 Importin repeat Importin_rep_5 PF18816.1 EFE37545.1 - 9.4e-23 80.3 0.3 3e-22 78.6 0.3 2.0 1 0 0 1 1 1 1 Importin repeat HEAT_2 PF13646.6 EFE37545.1 - 3e-20 72.4 4.4 0.00012 22.4 0.0 8.1 5 2 2 8 8 8 4 HEAT repeats HEAT_EZ PF13513.6 EFE37545.1 - 2e-19 69.7 12.1 1.4e-08 35.0 0.3 8.6 9 1 1 10 10 9 2 HEAT-like repeat HEAT PF02985.22 EFE37545.1 - 5.6e-18 63.5 5.8 0.008 16.4 0.0 10.9 11 0 0 11 11 9 4 HEAT repeat Importin_rep_6 PF18829.1 EFE37545.1 - 6.1e-14 52.1 0.8 3.4e-13 49.7 0.2 2.6 2 0 0 2 2 2 1 Importin repeat 6 Vac14_Fab1_bd PF12755.7 EFE37545.1 - 2e-09 37.9 0.0 0.11 13.1 0.0 5.9 3 2 2 6 6 6 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EFE37545.1 - 4.9e-09 35.8 1.9 0.00015 21.1 0.1 5.0 5 1 1 6 6 6 2 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 EFE37545.1 - 1.6e-07 31.4 1.8 0.25 11.3 0.0 6.3 6 2 1 8 8 8 2 Domain of unknown function (DUF3385) Cnd1 PF12717.7 EFE37545.1 - 7.1e-07 29.4 0.1 0.031 14.3 0.0 4.7 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 EFE37545.1 - 1.7e-06 27.9 0.1 0.0012 18.6 0.1 4.9 5 1 0 5 5 4 1 rRNA processing/ribosome biogenesis DRIM PF07539.12 EFE37545.1 - 4e-06 25.4 2.0 0.04 12.2 0.1 4.5 4 1 0 5 5 5 2 Down-regulated in metastasis Arm PF00514.23 EFE37545.1 - 1.2e-05 25.1 0.6 1.5 9.0 0.1 5.1 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EFE37545.1 - 3.8e-05 23.4 0.0 0.24 10.9 0.0 5.1 4 1 0 4 4 4 1 CLASP N terminal RTP1_C1 PF10363.9 EFE37545.1 - 6.9e-05 23.0 0.2 0.24 11.6 0.1 4.7 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 EFE37545.1 - 0.00095 17.8 1.2 0.015 13.8 0.1 3.3 3 1 1 4 4 4 1 Adaptin N terminal region DUF4042 PF13251.6 EFE37545.1 - 0.021 14.5 2.4 18 5.0 0.0 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF4042) V-ATPase_H_N PF03224.14 EFE37545.1 - 0.034 13.4 3.0 0.15 11.3 0.0 3.1 4 0 0 4 4 4 0 V-ATPase subunit H Cnd3 PF12719.7 EFE37545.1 - 0.044 13.0 0.9 4.2 6.5 0.0 4.0 3 1 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain TFCD_C PF12612.8 EFE37545.1 - 0.086 12.7 1.0 21 4.8 0.0 3.8 4 0 0 4 4 3 0 Tubulin folding cofactor D C terminal IBN_N PF03810.19 EFE37545.1 - 0.14 12.1 1.4 1.3 9.0 0.0 3.3 4 0 0 4 4 2 0 Importin-beta N-terminal domain Phosphodiest PF01663.22 EFE37547.1 - 2.6e-08 33.9 0.0 4.1e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFE37547.1 - 0.056 12.8 0.0 0.088 12.2 0.0 1.3 1 0 0 1 1 1 0 Sulfatase DUF2567 PF10821.8 EFE37547.1 - 0.8 9.8 5.0 14 5.7 1.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2567) Caveolin PF01146.17 EFE37548.1 - 0.037 14.0 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 Caveolin RRM_2 PF04059.12 EFE37551.1 - 1.4e-08 34.8 0.2 3.3e-08 33.6 0.2 1.5 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 EFE37551.1 - 7.6e-06 25.7 0.0 0.026 14.4 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mpp10 PF04006.12 EFE37552.1 - 0.8 8.1 27.1 1.7 7.0 27.2 1.3 1 1 0 1 1 1 0 Mpp10 protein Sod_Cu PF00080.20 EFE37554.1 - 4.8e-46 156.5 6.7 6.1e-46 156.1 6.7 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TAL_FSA PF00923.19 EFE37555.1 - 6.2e-94 314.6 0.1 7e-94 314.4 0.1 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase C5-epim_C PF06662.13 EFE37555.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 D-glucuronyl C5-epimerase C-terminus Beach PF02138.18 EFE37556.1 - 7.6e-119 396.2 0.0 1.4e-118 395.3 0.0 1.5 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EFE37556.1 - 6.7e-10 39.0 0.1 6.7e-10 39.0 0.1 2.2 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 EFE37556.1 - 4.2e-07 30.2 0.0 1e-06 28.9 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Peptidase_S8 PF00082.22 EFE37558.1 - 9.7e-39 133.4 3.0 1.4e-38 132.8 3.0 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE37558.1 - 4.4e-21 75.3 0.3 1.2e-20 74.0 0.3 1.8 1 0 0 1 1 1 1 Peptidase inhibitor I9 EXS PF03124.14 EFE37559.1 - 2e-74 250.9 14.6 2.3e-74 250.7 14.6 1.0 1 0 0 1 1 1 1 EXS family Paf1 PF03985.13 EFE37559.1 - 3.2 6.7 7.0 3.9 6.4 7.0 1.1 1 0 0 1 1 1 0 Paf1 SPX PF03105.19 EFE37560.1 - 2.7e-60 205.3 6.3 3.9e-60 204.8 6.3 1.2 1 0 0 1 1 1 1 SPX domain Ribosom_S30AE_C PF16321.5 EFE37560.1 - 0.13 12.0 1.4 0.23 11.2 0.1 2.0 2 0 0 2 2 2 0 Sigma 54 modulation/S30EA ribosomal protein C terminus Emaravirus_P4 PF16505.5 EFE37560.1 - 0.23 10.4 0.4 0.39 9.7 0.4 1.3 1 0 0 1 1 1 0 P4 movement protein of Emaravirus, and the 30K superfamily HAD_2 PF13419.6 EFE37561.1 - 1e-14 55.0 0.0 1.9e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFE37561.1 - 9.8e-07 29.3 0.0 1.5e-06 28.6 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE37561.1 - 1.5e-05 25.0 0.0 2.9e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like DUF1100 PF06500.11 EFE37562.1 - 3.8e-05 22.7 0.0 9.1e-05 21.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_6 PF12697.7 EFE37562.1 - 8e-05 23.3 0.0 0.00016 22.4 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family BAAT_C PF08840.11 EFE37562.1 - 0.00065 19.7 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EFE37562.1 - 0.0011 18.5 0.0 0.18 11.3 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EFE37562.1 - 0.0018 17.8 0.0 0.0055 16.2 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Zn_clus PF00172.18 EFE37563.1 - 6.2e-05 23.0 4.5 0.00011 22.2 4.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EFE37563.1 - 0.00086 18.2 1.1 0.0011 17.8 1.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Abhydrolase_2 PF02230.16 EFE37564.1 - 3.9e-21 75.9 0.0 5e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EFE37564.1 - 1.1e-05 26.1 0.3 1.5e-05 25.7 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family XylR_N PF06505.11 EFE37564.1 - 0.035 13.9 0.1 0.063 13.0 0.1 1.4 1 0 0 1 1 1 0 Activator of aromatic catabolism ThiD2 PF17792.1 EFE37565.1 - 0.035 14.6 0.7 0.18 12.3 0.1 2.4 3 0 0 3 3 3 0 ThiD2 family Metallophos PF00149.28 EFE37566.1 - 2.7e-37 129.3 0.6 6.2e-37 128.1 0.2 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 EFE37566.1 - 0.11 12.2 0.6 1.7 8.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) CortBP2 PF09727.9 EFE37569.1 - 0.013 15.4 0.5 0.028 14.3 0.4 1.6 2 0 0 2 2 2 0 Cortactin-binding protein-2 FPP PF05911.11 EFE37569.1 - 0.013 13.7 2.0 0.017 13.4 2.0 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil MogR_DNAbind PF12181.8 EFE37569.1 - 0.1 12.5 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 DNA binding domain of the motility gene repressor (MogR) Voldacs PF03517.13 EFE37570.1 - 5.3e-13 49.3 1.9 5.3e-13 49.3 1.9 2.0 2 0 0 2 2 2 1 Regulator of volume decrease after cellular swelling LIP PF03583.14 EFE37571.1 - 4.7e-70 236.2 0.0 6.1e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase RRN3 PF05327.11 EFE37572.1 - 0.038 12.6 0.0 0.048 12.2 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 MscL PF01741.18 EFE37572.1 - 0.24 11.7 0.0 0.38 11.1 0.0 1.3 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL HTH_30 PF13556.6 EFE37572.1 - 0.43 10.4 3.5 1.1 9.2 3.5 1.7 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Cytokin_check_N PF10407.9 EFE37574.1 - 0.00036 20.4 0.0 0.00075 19.4 0.0 1.4 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus Thioesterase PF00975.20 EFE37575.1 - 1.3e-17 64.7 0.0 3.5e-17 63.3 0.0 1.8 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EFE37575.1 - 7.6e-08 33.2 0.0 9.4e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFE37575.1 - 0.00036 20.3 0.1 0.00065 19.4 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EFE37575.1 - 0.0088 15.9 0.0 0.019 14.8 0.0 1.5 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 EFE37575.1 - 0.083 12.7 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold p450 PF00067.22 EFE37576.1 - 4e-56 190.7 0.0 5e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Phage_ASH PF10554.9 EFE37577.1 - 0.06 13.7 0.1 0.094 13.1 0.1 1.3 1 0 0 1 1 1 0 Ash protein family Bacillus_PapR PF05968.11 EFE37577.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 Bacillus PapR protein MFS_1 PF07690.16 EFE37578.1 - 8.9e-13 47.9 19.9 1.6e-10 40.5 10.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE37578.1 - 1.4e-05 24.1 4.5 1.4e-05 24.1 4.5 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter Ycf9 PF01737.17 EFE37578.1 - 2.5 8.0 7.8 18 5.3 0.8 3.5 3 0 0 3 3 3 0 YCF9 AA_permease PF00324.21 EFE37579.1 - 3.4e-137 457.9 45.1 4.1e-137 457.7 45.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE37579.1 - 3.3e-38 131.6 48.8 4.2e-38 131.3 48.8 1.1 1 0 0 1 1 1 1 Amino acid permease Abhydrolase_1 PF00561.20 EFE37580.1 - 5.2e-05 23.0 0.0 0.017 14.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold LIP PF03583.14 EFE37580.1 - 9.7e-05 21.8 0.0 0.24 10.7 0.0 2.2 2 0 0 2 2 2 2 Secretory lipase Abhydrolase_3 PF07859.13 EFE37580.1 - 0.00011 22.1 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE37580.1 - 0.00025 20.4 0.0 0.0016 17.7 0.0 1.9 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFE37580.1 - 0.00074 20.2 2.3 0.0012 19.5 2.3 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EFE37580.1 - 0.00084 19.0 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EFE37580.1 - 0.004 16.7 0.0 0.0078 15.7 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family CCDC106 PF15794.5 EFE37581.1 - 0.12 12.1 0.4 0.24 11.1 0.4 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Methyltransf_23 PF13489.6 EFE37582.1 - 3.4e-17 62.8 0.0 6.4e-17 61.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE37582.1 - 7.2e-07 29.8 0.0 2.4e-06 28.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE37582.1 - 1.5e-05 25.7 0.0 4e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE37582.1 - 3.2e-05 23.8 0.0 0.017 14.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EFE37582.1 - 0.0042 17.7 0.0 0.009 16.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFE37582.1 - 0.1 12.4 0.0 0.56 9.9 0.0 2.0 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UQ_con PF00179.26 EFE37583.1 - 0.00034 20.3 0.0 0.00058 19.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ACC_epsilon PF13822.6 EFE37583.1 - 6.7 7.5 12.4 8.3 7.2 5.9 2.7 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit AAA_11 PF13086.6 EFE37584.1 - 2.3e-63 214.4 0.4 2.3e-63 214.4 0.4 3.0 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.6 EFE37584.1 - 2e-47 161.4 0.0 5.4e-47 160.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain HhH-GPD PF00730.25 EFE37584.1 - 2.6e-20 72.9 0.1 1.6e-19 70.3 0.0 2.5 3 0 0 3 3 1 1 HhH-GPD superfamily base excision DNA repair protein AAA_30 PF13604.6 EFE37584.1 - 3.4e-13 49.7 0.0 5.1e-12 45.9 0.0 2.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFE37584.1 - 1.8e-10 41.3 0.0 1e-09 38.9 0.0 2.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EFE37584.1 - 3e-07 30.6 0.0 1.1e-06 28.7 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EFE37584.1 - 6.8e-07 28.9 0.2 5.6e-06 25.8 0.2 2.3 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) HHH PF00633.23 EFE37584.1 - 1.9e-06 27.4 0.0 5.3e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif Viral_helicase1 PF01443.18 EFE37584.1 - 1.2e-05 25.2 0.1 0.29 10.8 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase PIF1 PF05970.14 EFE37584.1 - 2.1e-05 23.9 0.0 0.22 10.6 0.0 2.7 3 0 0 3 3 3 2 PIF1-like helicase AAA_22 PF13401.6 EFE37584.1 - 2.3e-05 24.7 0.1 0.00022 21.5 0.1 2.6 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EFE37584.1 - 0.00011 22.2 0.0 0.0085 16.0 0.0 3.3 2 1 0 2 2 2 1 Helicase AAA_16 PF13191.6 EFE37584.1 - 0.00024 21.5 0.5 0.0011 19.4 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 EFE37584.1 - 0.00029 20.0 0.0 0.00069 18.8 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein Flavi_DEAD PF07652.14 EFE37584.1 - 0.0013 18.7 0.1 0.0035 17.3 0.1 1.7 1 0 0 1 1 1 1 Flavivirus DEAD domain UvrD-helicase PF00580.21 EFE37584.1 - 0.0016 18.0 0.2 0.0016 18.0 0.2 2.5 3 1 0 3 3 1 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 EFE37584.1 - 0.0018 17.8 0.0 0.031 13.7 0.0 2.5 1 1 0 1 1 1 1 PhoH-like protein TrwB_AAD_bind PF10412.9 EFE37584.1 - 0.003 16.5 0.0 0.0083 15.1 0.0 1.7 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain FXR_C1 PF16096.5 EFE37584.1 - 0.0062 16.7 5.0 0.031 14.5 5.0 2.2 1 0 0 1 1 1 1 Fragile X-related 1 protein C-terminal region 2 AAA_5 PF07728.14 EFE37584.1 - 0.011 15.8 0.0 0.048 13.7 0.0 2.2 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EFE37584.1 - 0.015 15.7 0.0 0.11 12.9 0.0 2.5 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EFE37584.1 - 0.022 14.5 0.0 0.054 13.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EFE37584.1 - 0.023 14.4 0.0 0.089 12.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain CbiA PF01656.23 EFE37584.1 - 0.05 13.6 0.2 0.22 11.6 0.0 2.3 3 0 0 3 3 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Herpes_ori_bp PF02399.15 EFE37584.1 - 0.069 11.2 0.0 0.13 10.2 0.0 1.4 1 0 0 1 1 1 0 Origin of replication binding protein TK PF00265.18 EFE37584.1 - 0.097 12.5 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 Thymidine kinase 4HB_MCP_1 PF12729.7 EFE37584.1 - 0.12 12.0 2.4 0.12 11.9 0.0 2.1 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Mg_chelatase PF01078.21 EFE37584.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI CmcI PF04989.12 EFE37584.1 - 0.16 11.7 0.1 0.36 10.5 0.1 1.6 1 0 0 1 1 1 0 Cephalosporin hydroxylase AAA_23 PF13476.6 EFE37584.1 - 1.9 9.0 0.0 1.9 9.0 0.0 3.5 4 0 0 4 4 4 0 AAA domain Pkinase PF00069.25 EFE37585.1 - 1.4e-29 103.3 0.0 1.6e-29 103.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37585.1 - 2e-22 79.7 0.0 9.3e-22 77.5 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE37585.1 - 1.2e-05 24.3 0.0 1.3e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFE37585.1 - 5e-05 22.4 0.0 6.6e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFE37585.1 - 0.00034 20.6 0.1 0.0013 18.7 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EFE37585.1 - 0.0084 15.8 0.1 1.3 8.6 0.1 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EFE37585.1 - 0.0089 15.6 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFE37586.1 - 9.4e-12 45.4 0.0 1.3e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE37586.1 - 0.00027 20.6 0.0 0.00071 19.2 0.0 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 EFE37586.1 - 0.021 14.4 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 RIO1 family C2 PF00168.30 EFE37587.1 - 4.5e-73 242.1 0.6 6.3e-19 68.2 0.0 5.5 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 EFE37587.1 - 0.012 15.0 0.0 0.06 12.8 0.0 2.0 1 1 0 1 1 1 0 Synaptotagmin-like mitochondrial-lipid-binding domain TPR_1 PF00515.28 EFE37588.1 - 7.2e-38 126.9 27.7 2.2e-05 24.1 0.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 EFE37588.1 - 1.1e-36 124.5 7.5 4.8e-20 71.2 0.6 2.9 2 0 0 2 2 2 2 STI1 domain TPR_2 PF07719.17 EFE37588.1 - 1.3e-29 99.9 26.7 0.00026 20.9 0.1 9.8 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFE37588.1 - 4e-17 61.6 21.2 0.0039 16.8 0.1 7.9 6 1 2 8 8 8 5 TPR repeat TPR_19 PF14559.6 EFE37588.1 - 1.2e-15 57.7 22.6 0.00062 20.2 0.3 6.6 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFE37588.1 - 1.6e-14 52.8 24.1 0.01 16.0 0.1 9.0 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 EFE37588.1 - 3.9e-10 39.7 4.7 0.0022 18.1 0.1 4.8 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFE37588.1 - 1.3e-09 38.5 16.9 0.032 14.9 0.3 6.5 3 2 3 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFE37588.1 - 5.6e-09 36.2 21.4 0.0002 21.6 0.2 6.4 5 3 2 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFE37588.1 - 1.2e-08 35.0 22.3 1.7 9.7 0.2 9.2 7 3 3 10 10 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFE37588.1 - 7.1e-08 32.3 10.4 0.021 15.2 0.1 6.8 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFE37588.1 - 6.1e-07 29.0 13.5 0.0073 16.3 0.0 6.7 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFE37588.1 - 2.6e-05 23.9 9.0 0.31 11.0 0.1 6.5 5 1 1 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE37588.1 - 0.0029 17.8 11.0 0.24 11.6 0.2 3.9 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFE37588.1 - 0.011 16.4 21.9 1.3 9.8 0.0 8.6 9 0 0 9 9 9 0 Tetratricopeptide repeat SPESP1 PF15754.5 EFE37588.1 - 0.036 13.3 1.2 0.095 11.9 1.2 1.7 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Inhibitor_I9 PF05922.16 EFE37588.1 - 0.09 13.5 0.0 0.43 11.3 0.0 2.2 1 0 0 1 1 1 0 Peptidase inhibitor I9 SHNi-TPR PF10516.9 EFE37588.1 - 2.9 7.4 10.3 20 4.7 0.1 5.6 6 0 0 6 6 6 0 SHNi-TPR Trypan_PARP PF05887.11 EFE37588.1 - 4.6 7.2 23.3 0.092 12.7 13.2 2.8 3 0 0 3 3 3 0 Procyclic acidic repetitive protein (PARP) RNA_pol_Rpc34 PF05158.12 EFE37589.1 - 1.2e-100 337.2 0.0 1.5e-100 336.9 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit ING PF12998.7 EFE37590.1 - 1.7e-22 79.9 3.6 2.8e-22 79.2 3.6 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EFE37590.1 - 2.7e-05 24.0 9.7 5.1e-05 23.1 9.7 1.5 1 0 0 1 1 1 1 PHD-finger TFIIA PF03153.13 EFE37590.1 - 0.0019 18.3 6.7 0.0029 17.7 6.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit zf-HC5HC2H PF13771.6 EFE37590.1 - 0.047 13.9 0.3 0.11 12.8 0.3 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain Prominin PF05478.11 EFE37590.1 - 0.058 11.3 1.0 0.13 10.2 0.3 1.7 2 0 0 2 2 2 0 Prominin PHD_2 PF13831.6 EFE37590.1 - 0.55 9.8 3.8 1.1 8.8 3.8 1.5 1 0 0 1 1 1 0 PHD-finger Hamartin PF04388.12 EFE37590.1 - 2.3 6.8 12.2 3.4 6.2 12.2 1.1 1 0 0 1 1 1 0 Hamartin protein Hist_deacetyl PF00850.19 EFE37591.1 - 9.2e-78 261.8 0.0 1.3e-77 261.3 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain BSP_II PF05432.11 EFE37591.1 - 0.97 9.1 6.5 1.4 8.5 6.5 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Isochorismatase PF00857.20 EFE37592.1 - 8.9e-25 87.9 0.1 1.3e-20 74.3 0.0 2.1 2 0 0 2 2 2 2 Isochorismatase family F-box-like PF12937.7 EFE37593.1 - 0.00033 20.5 0.6 0.00091 19.1 0.6 1.8 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFE37593.1 - 0.0014 18.5 0.1 0.0029 17.5 0.1 1.5 1 0 0 1 1 1 1 F-box F-box PF00646.33 EFE37593.1 - 0.0022 17.8 0.9 0.0052 16.6 0.9 1.6 1 0 0 1 1 1 1 F-box domain ssDBP_DBD PF18361.1 EFE37594.1 - 0.14 12.3 0.1 0.27 11.4 0.1 1.4 1 0 0 1 1 1 0 Single stranded DNA-binding protein ss DNA binding domain ICE2 PF08426.10 EFE37595.1 - 2e-151 504.8 17.1 2.2e-151 504.6 17.1 1.0 1 0 0 1 1 1 1 ICE2 Endosulfine PF04667.17 EFE37596.1 - 3.1e-28 97.7 0.3 6.6e-28 96.7 0.3 1.5 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region RNA_Me_trans PF04252.13 EFE37597.1 - 4e-30 104.9 0.0 4.4e-30 104.8 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Peptidase_S10 PF00450.22 EFE37598.1 - 1.6e-91 307.8 0.0 2e-91 307.5 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase SnoaL PF07366.12 EFE37599.1 - 0.027 14.3 0.1 0.045 13.6 0.1 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase Mito_carr PF00153.27 EFE37600.1 - 3.2e-45 152.0 6.1 1.7e-19 69.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CBS PF00571.28 EFE37601.1 - 0.00013 22.3 0.0 2.9 8.4 0.0 3.3 1 1 2 3 3 3 3 CBS domain MFS_1 PF07690.16 EFE37602.1 - 7.9e-43 146.7 53.5 4.4e-42 144.3 53.0 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE37602.1 - 3.8e-17 62.0 17.6 3.8e-17 62.0 17.6 1.6 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFE37602.1 - 1.8e-11 43.6 11.0 1.8e-11 43.6 11.0 3.5 4 1 0 4 4 4 1 Sugar (and other) transporter ECH_1 PF00378.20 EFE37604.1 - 1.3e-41 142.6 0.0 2.4e-41 141.7 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFE37604.1 - 4.6e-28 98.7 0.0 6.3e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pox_P21 PF05313.12 EFE37604.1 - 0.23 11.0 0.0 0.35 10.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus P21 membrane protein NB-ARC PF00931.22 EFE37605.1 - 9e-09 34.9 0.0 1.6e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EFE37605.1 - 6e-06 26.7 2.9 2.5e-05 24.7 0.0 3.5 4 1 0 4 4 4 1 AAA ATPase domain PGAP1 PF07819.13 EFE37605.1 - 1.4e-05 24.9 0.0 9.7e-05 22.2 0.0 2.0 1 1 1 2 2 2 1 PGAP1-like protein DUF676 PF05057.14 EFE37605.1 - 0.00014 21.5 0.4 0.00063 19.3 0.3 1.9 1 1 0 1 1 1 1 Putative serine esterase (DUF676) AAA_33 PF13671.6 EFE37605.1 - 0.0081 16.3 0.0 0.038 14.2 0.0 2.1 1 0 0 1 1 1 1 AAA domain Abhydrolase_6 PF12697.7 EFE37605.1 - 0.018 15.6 0.3 0.018 15.6 0.3 3.0 2 2 0 2 2 1 0 Alpha/beta hydrolase family AAA_22 PF13401.6 EFE37605.1 - 0.022 15.0 0.0 0.067 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain Hydrolase_4 PF12146.8 EFE37605.1 - 0.023 14.0 0.0 0.049 12.9 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 NACHT PF05729.12 EFE37605.1 - 0.026 14.4 0.2 0.24 11.3 0.0 2.4 2 1 0 2 2 1 0 NACHT domain Zeta_toxin PF06414.12 EFE37605.1 - 0.05 12.9 0.0 0.05 12.9 0.0 1.7 2 0 0 2 2 1 0 Zeta toxin Sigma54_activat PF00158.26 EFE37605.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase PF06745.13 EFE37605.1 - 0.071 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 KaiC DUF3484 PF11983.8 EFE37605.1 - 1.3 10.2 6.9 7.4 7.8 6.9 2.4 1 0 0 1 1 1 0 Membrane-attachment and polymerisation-promoting switch HMG_box PF00505.19 EFE37606.1 - 4.5e-24 84.6 0.5 4.5e-24 84.6 0.5 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFE37606.1 - 2.9e-18 66.2 0.9 4.7e-18 65.6 0.9 1.3 1 0 0 1 1 1 1 HMG-box domain Ccdc124 PF06244.12 EFE37606.1 - 0.0029 18.1 1.7 0.0047 17.5 0.3 2.1 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 CHDNT PF08073.12 EFE37606.1 - 0.061 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 CHDNT (NUC034) domain ThiF PF00899.21 EFE37609.1 - 7.8e-56 189.2 0.0 1.2e-55 188.6 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EFE37609.1 - 4e-09 37.0 0.0 9.1e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain YlqD PF11068.8 EFE37609.1 - 0.056 13.8 2.7 0.092 13.1 2.7 1.3 1 0 0 1 1 1 0 YlqD protein FAD_binding_3 PF01494.19 EFE37609.1 - 0.073 12.3 0.8 0.11 11.7 0.8 1.2 1 0 0 1 1 1 0 FAD binding domain GPS2_interact PF15784.5 EFE37609.1 - 0.12 12.9 1.3 0.22 12.0 1.3 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain DAO PF01266.24 EFE37609.1 - 0.12 11.9 0.1 0.22 11.0 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Spc24 PF08286.11 EFE37609.1 - 0.14 12.4 1.0 0.25 11.6 1.0 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Shikimate_DH PF01488.20 EFE37609.1 - 0.21 11.7 0.5 0.37 10.9 0.0 1.6 2 0 0 2 2 1 0 Shikimate / quinate 5-dehydrogenase ABC_tran_CTD PF16326.5 EFE37609.1 - 0.38 11.0 3.9 0.61 10.4 3.9 1.3 1 0 0 1 1 1 0 ABC transporter C-terminal domain FlxA PF14282.6 EFE37609.1 - 0.41 10.7 4.7 0.7 9.9 4.7 1.4 1 0 0 1 1 1 0 FlxA-like protein DivIC PF04977.15 EFE37609.1 - 0.49 10.2 3.3 0.87 9.4 3.3 1.3 1 0 0 1 1 1 0 Septum formation initiator HR1 PF02185.16 EFE37609.1 - 0.51 10.5 4.5 0.97 9.6 4.5 1.5 1 0 0 1 1 1 0 Hr1 repeat Swi5 PF07061.11 EFE37609.1 - 0.58 10.3 1.8 1.3 9.2 1.8 1.5 1 0 0 1 1 1 0 Swi5 SLX9 PF15341.6 EFE37610.1 - 1.6e-37 128.9 3.7 1.6e-37 128.9 3.7 1.6 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 NAD_Gly3P_dh_C PF07479.14 EFE37611.1 - 2.9e-43 147.5 0.1 4.9e-43 146.8 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 EFE37611.1 - 1.5e-35 122.5 0.0 2.5e-35 121.8 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus hDGE_amylase PF14701.6 EFE37612.1 - 1.4e-171 571.4 0.0 1.9e-171 571.0 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EFE37612.1 - 6.2e-123 410.5 0.2 1e-122 409.8 0.0 1.5 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EFE37612.1 - 1.6e-85 286.8 0.0 8e-85 284.5 0.0 2.1 2 0 0 2 2 2 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EFE37612.1 - 1.5e-28 98.7 0.0 2.9e-28 97.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme RIX1 PF08167.12 EFE37612.1 - 0.23 11.2 0.1 0.87 9.3 0.1 1.9 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis RSN1_7TM PF02714.15 EFE37613.1 - 1.9e-62 211.1 24.4 1.9e-62 211.1 24.4 2.5 2 1 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EFE37613.1 - 1.6e-41 142.4 0.0 2.5e-41 141.9 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EFE37613.1 - 3.1e-35 121.2 0.6 3.1e-35 121.2 0.6 2.8 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport Lig_chan PF00060.26 EFE37613.1 - 0.14 12.0 0.1 1 9.2 0.1 2.4 2 0 0 2 2 2 0 Ligand-gated ion channel DUF4293 PF14126.6 EFE37613.1 - 0.39 10.9 0.0 0.39 10.9 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4293) MFS_1 PF07690.16 EFE37614.1 - 8.1e-16 57.9 30.6 8.1e-16 57.9 30.6 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily DAHP_synth_1 PF00793.20 EFE37615.1 - 3e-103 344.4 0.1 3.8e-103 344.1 0.1 1.0 1 0 0 1 1 1 1 DAHP synthetase I family AIG2_2 PF13772.6 EFE37617.1 - 1e-05 25.8 0.0 0.00013 22.3 0.0 2.3 2 0 0 2 2 2 1 AIG2-like family Cytochrom_C1 PF02167.15 EFE37618.1 - 1.2e-92 309.5 0.0 1.6e-92 309.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family SbcCD_C PF13558.6 EFE37618.1 - 0.0017 18.6 0.4 0.0036 17.5 0.4 1.5 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Cytochrome_CBB3 PF13442.6 EFE37618.1 - 0.054 13.8 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III AAA PF00004.29 EFE37619.1 - 5.9e-27 94.7 0.0 1.3e-26 93.5 0.0 1.6 1 1 1 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFE37619.1 - 2.9e-06 27.8 0.0 6.2e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFE37619.1 - 4.2e-06 27.3 0.0 1.2e-05 25.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFE37619.1 - 8.2e-06 26.1 0.0 2.2e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFE37619.1 - 9.6e-05 22.0 0.0 0.00025 20.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EFE37619.1 - 0.00041 20.7 0.1 0.0013 19.1 0.0 1.9 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.6 EFE37619.1 - 0.00064 19.8 0.0 0.0012 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFE37619.1 - 0.00082 19.4 0.1 0.0024 17.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFE37619.1 - 0.00087 19.1 0.1 0.012 15.4 0.0 2.2 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EFE37619.1 - 0.0014 18.4 0.1 0.0043 16.8 0.0 1.8 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 EFE37619.1 - 0.0021 18.0 0.0 0.0034 17.3 0.0 1.5 1 1 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 EFE37619.1 - 0.0033 17.6 0.0 0.0053 16.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 EFE37619.1 - 0.0045 17.0 0.0 0.008 16.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EFE37619.1 - 0.0078 16.1 0.0 0.068 13.1 0.0 2.2 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EFE37619.1 - 0.008 16.4 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EFE37619.1 - 0.0096 15.7 0.0 0.03 14.1 0.0 1.8 2 0 0 2 2 2 1 Cytidylate kinase IstB_IS21 PF01695.17 EFE37619.1 - 0.0099 15.6 0.0 0.03 14.1 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_17 PF13207.6 EFE37619.1 - 0.012 16.0 0.3 0.13 12.7 0.0 2.3 1 1 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EFE37619.1 - 0.02 14.7 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EFE37619.1 - 0.021 14.0 0.0 0.045 12.9 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_13 PF13166.6 EFE37619.1 - 0.026 13.2 0.0 0.045 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFE37619.1 - 0.026 14.0 0.0 0.077 12.5 0.0 1.7 2 0 0 2 2 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EFE37619.1 - 0.027 13.9 0.0 0.13 11.6 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EFE37619.1 - 0.029 14.5 0.0 0.063 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) DnaB_C PF03796.15 EFE37619.1 - 0.034 13.5 0.0 0.17 11.2 0.0 1.7 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain AAA_30 PF13604.6 EFE37619.1 - 0.049 13.4 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EFE37619.1 - 0.063 13.1 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFE37619.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain TIP49 PF06068.13 EFE37619.1 - 0.079 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_19 PF13245.6 EFE37619.1 - 0.098 13.0 0.0 0.26 11.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain KTI12 PF08433.10 EFE37619.1 - 0.13 11.7 0.2 0.6 9.5 0.0 1.9 1 1 0 2 2 2 0 Chromatin associated protein KTI12 PduV-EutP PF10662.9 EFE37619.1 - 0.16 11.7 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EFE37619.1 - 0.19 12.3 0.0 0.37 11.3 0.0 1.5 1 1 0 1 1 1 0 ABC transporter Sec10 PF07393.11 EFE37620.1 - 4.7e-148 494.7 0.0 6e-148 494.4 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 EFE37620.1 - 0.00018 21.3 0.0 0.00041 20.2 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE37620.1 - 0.00019 21.2 0.9 0.00034 20.4 0.0 1.8 2 0 0 2 2 2 1 F-box domain RINT1_TIP1 PF04437.13 EFE37620.1 - 0.04 12.8 0.0 0.11 11.3 0.0 1.7 2 0 0 2 2 2 0 RINT-1 / TIP-1 family WD40 PF00400.32 EFE37621.1 - 8e-54 178.4 32.6 2.5e-11 43.9 0.7 9.5 9 1 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE37621.1 - 7.4e-19 67.9 6.0 0.00032 20.9 0.1 5.8 2 2 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE37621.1 - 1.8e-06 26.9 6.4 2.1 6.9 0.0 5.7 4 2 2 6 6 6 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFE37621.1 - 5.4e-06 25.6 0.1 0.031 13.2 0.0 4.1 3 1 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFE37621.1 - 1.1e-05 25.4 0.1 0.42 10.5 0.1 3.7 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A NLE PF08154.12 EFE37621.1 - 8.2e-05 23.1 0.0 0.00017 22.0 0.0 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain DUF4550 PF15084.6 EFE37621.1 - 0.0059 17.0 0.2 0.11 12.9 0.0 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4550) PD40 PF07676.12 EFE37621.1 - 0.058 13.4 1.0 5.3 7.1 0.0 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EFE37621.1 - 0.23 10.7 0.0 17 4.6 0.0 3.4 3 1 1 4 4 4 0 WD40-like domain MutS_II PF05188.17 EFE37622.1 - 4.5e-10 40.0 0.1 5.3e-10 39.7 0.1 1.2 1 0 0 1 1 1 1 MutS domain II MutS_V PF00488.21 EFE37623.1 - 1.3e-61 208.0 0.8 2e-61 207.3 0.8 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFE37623.1 - 2.1e-26 93.4 2.8 4.3e-26 92.3 0.9 2.4 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EFE37623.1 - 2.7e-08 34.0 1.2 2.2e-05 24.7 0.5 3.6 2 1 0 2 2 2 1 MutS family domain IV AAA_30 PF13604.6 EFE37623.1 - 0.0035 17.1 0.1 0.0073 16.0 0.1 1.5 1 0 0 1 1 1 1 AAA domain DUF3213 PF11491.8 EFE37623.1 - 0.072 13.3 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3213) AAA_14 PF13173.6 EFE37623.1 - 0.098 12.7 0.0 0.33 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain PSD5 PF07637.11 EFE37623.1 - 0.11 12.8 0.1 1.8 8.9 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1595) Tudor-knot PF11717.8 EFE37624.1 - 0.14 12.1 0.1 0.32 10.9 0.1 1.5 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain RSN1_7TM PF02714.15 EFE37625.1 - 3.2e-85 285.8 28.1 1.8e-84 283.3 24.2 2.4 2 0 0 2 2 2 2 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFE37625.1 - 6.5e-43 146.2 1.9 6.5e-43 146.2 1.9 2.6 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 EFE37625.1 - 3.5e-27 94.4 0.5 1.3e-26 92.6 0.2 2.1 3 0 0 3 3 3 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 EFE37625.1 - 1.9e-25 90.1 0.1 3e-25 89.5 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Rubella_E2 PF05749.11 EFE37625.1 - 0.075 12.5 0.0 0.2 11.1 0.0 1.6 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 BORCS8 PF10167.9 EFE37627.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 8 Abhydrolase_1 PF00561.20 EFE37628.1 - 2.6e-25 89.5 0.0 3.7e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE37628.1 - 3.8e-10 39.5 0.0 8.2e-10 38.3 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFE37628.1 - 4e-05 24.3 0.0 5.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EFE37628.1 - 0.053 13.2 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Putative esterase Ndr PF03096.14 EFE37628.1 - 0.17 10.6 0.0 0.24 10.0 0.0 1.1 1 0 0 1 1 1 0 Ndr family Carbpep_Y_N PF05388.11 EFE37629.1 - 0.016 15.7 0.0 0.041 14.4 0.0 1.7 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide Peptidase_S10 PF00450.22 EFE37629.1 - 0.092 12.1 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase Peptidase_S10 PF00450.22 EFE37630.1 - 2.8e-87 293.8 0.0 3.2e-87 293.7 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase NmrA PF05368.13 EFE37631.1 - 6.6e-06 25.9 0.0 0.022 14.3 0.0 2.1 1 1 1 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 EFE37631.1 - 0.0027 17.6 0.0 0.014 15.3 0.0 2.0 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EFE37631.1 - 0.072 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DLH PF01738.18 EFE37632.1 - 1.3e-29 103.3 0.0 1.5e-29 103.1 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 EFE37632.1 - 0.069 12.9 0.0 0.26 11.0 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family eIF2A PF08662.11 EFE37633.1 - 2.9e-36 125.2 6.4 3.7e-34 118.3 1.5 3.9 3 3 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EFE37633.1 - 3.2e-07 30.1 0.1 9e-07 28.6 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 EFE37633.1 - 0.0024 18.7 0.9 0.25 12.3 0.1 4.3 5 0 0 5 5 5 1 WD domain, G-beta repeat PRP3 PF08572.10 EFE37633.1 - 0.0043 16.8 0.2 0.013 15.2 0.2 1.7 1 1 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) SWIB PF02201.18 EFE37634.1 - 3.1e-23 81.4 0.1 5.3e-23 80.7 0.1 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain Mcm10 PF09332.11 EFE37634.1 - 0.0077 15.7 4.3 0.009 15.5 4.3 1.1 1 0 0 1 1 1 1 Mcm10 replication factor Fungal_trans_2 PF11951.8 EFE37635.1 - 2.8e-54 184.4 0.0 4.2e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE37635.1 - 0.025 14.7 8.7 0.045 13.9 8.7 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Pam17 PF08566.10 EFE37636.1 - 2.2e-66 222.8 0.1 2.9e-66 222.4 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 Cpn60_TCP1 PF00118.24 EFE37640.1 - 1.8e-122 409.4 12.2 2.2e-122 409.2 12.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pro_isomerase PF00160.21 EFE37641.1 - 1.6e-51 174.7 0.1 3.7e-51 173.5 0.1 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EFE37641.1 - 2e-07 31.6 0.1 0.2 12.6 0.0 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat CRM1_C PF08767.11 EFE37641.1 - 0.18 11.0 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 CRM1 C terminal Ribonuc_2-5A PF06479.12 EFE37642.1 - 5.9e-40 136.4 0.1 1.5e-39 135.1 0.0 1.7 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase PF00069.25 EFE37642.1 - 1.8e-38 132.4 0.0 3.8e-36 124.8 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37642.1 - 3.2e-19 69.2 0.0 3e-18 66.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 EFE37642.1 - 0.00011 22.0 0.1 0.11 12.4 0.0 3.5 3 0 0 3 3 3 1 PQQ enzyme repeat Kdo PF06293.14 EFE37642.1 - 0.0006 19.2 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFE37642.1 - 0.0017 17.2 0.0 0.0017 17.2 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase PQQ_2 PF13360.6 EFE37642.1 - 0.003 17.2 0.1 0.034 13.7 0.1 2.2 1 1 0 1 1 1 1 PQQ-like domain YrbL-PhoP_reg PF10707.9 EFE37642.1 - 0.014 15.0 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL HAD_2 PF13419.6 EFE37643.1 - 6.6e-14 52.4 0.0 9.4e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFE37643.1 - 1.9e-07 31.6 0.0 2.1e-06 28.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE37643.1 - 0.032 14.3 0.0 0.091 12.8 0.0 1.8 2 0 0 2 2 2 0 HAD-hyrolase-like WD40 PF00400.32 EFE37646.1 - 0.12 13.3 0.3 3.6e+02 2.3 0.0 4.6 5 0 0 5 5 5 0 WD domain, G-beta repeat Nucleoporin_FG PF13634.6 EFE37647.1 - 5.4e-07 30.4 72.4 0.011 16.6 27.2 3.5 1 1 2 3 3 3 3 Nucleoporin FG repeat region DUF1664 PF07889.12 EFE37647.1 - 0.0037 17.3 0.9 1.2 9.1 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) DUF5082 PF16888.5 EFE37647.1 - 0.076 13.3 2.4 1.3 9.3 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Prominin PF05478.11 EFE37647.1 - 0.09 10.7 0.3 0.43 8.5 0.0 1.9 2 0 0 2 2 2 0 Prominin Cpn10 PF00166.21 EFE37649.1 - 2.8e-24 85.0 0.0 4.8e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Fip1 PF05182.13 EFE37649.1 - 1.7e-20 72.2 1.9 3e-20 71.5 1.9 1.4 1 0 0 1 1 1 1 Fip1 motif Nop53 PF07767.11 EFE37649.1 - 0.042 13.2 5.1 0.067 12.6 5.1 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) WRNPLPNID PF15017.6 EFE37649.1 - 1.4 9.8 11.1 4.4 8.3 11.1 1.9 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Lin-8 PF03353.15 EFE37649.1 - 1.8 8.1 8.8 2.7 7.5 8.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Nop14 PF04147.12 EFE37649.1 - 4 5.5 14.1 5 5.2 14.1 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EFE37649.1 - 4 5.4 12.5 5.5 5.0 12.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 EFE37649.1 - 6 6.2 12.2 8.2 5.8 12.2 1.2 1 0 0 1 1 1 0 SDA1 XAP5 PF04921.14 EFE37650.1 - 2.1e-83 280.0 0.0 3.9e-83 279.1 0.0 1.4 1 1 0 1 1 1 1 XAP5, circadian clock regulator DUF4604 PF15377.6 EFE37650.1 - 0.0046 17.4 6.0 0.009 16.5 6.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) TCP PF03634.13 EFE37651.1 - 0.042 14.4 0.2 0.093 13.3 0.2 1.7 1 1 0 1 1 1 0 TCP family transcription factor Ndr PF03096.14 EFE37651.1 - 0.11 11.1 0.1 0.14 10.8 0.1 1.1 1 0 0 1 1 1 0 Ndr family DUF1031 PF06275.11 EFE37651.1 - 0.18 12.1 1.8 0.26 11.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) zf-C3HC4_3 PF13920.6 EFE37652.1 - 2e-09 37.1 12.2 3.5e-09 36.4 12.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFE37652.1 - 0.12 12.3 13.1 0.22 11.4 13.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FA_hydroxylase PF04116.13 EFE37653.1 - 6.7e-23 81.5 13.4 6.7e-23 81.5 13.4 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily UNC-79 PF14776.6 EFE37653.1 - 0.023 13.5 0.0 0.032 13.0 0.0 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 Aldo_ket_red PF00248.21 EFE37654.1 - 3.5e-60 203.7 0.0 4.2e-60 203.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Kelch_5 PF13854.6 EFE37655.1 - 5.6e-11 42.2 7.3 8.8e-11 41.6 0.4 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 EFE37655.1 - 1.4e-05 24.6 1.8 0.091 12.4 0.3 4.6 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 EFE37655.1 - 1.7e-05 24.7 1.2 0.0018 18.2 0.1 4.0 3 1 1 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 EFE37655.1 - 5.8e-05 23.3 3.4 0.0014 18.8 0.1 4.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EFE37655.1 - 0.0029 17.9 3.7 0.02 15.2 0.1 3.8 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 EFE37655.1 - 0.04 13.9 0.3 8.4 6.5 0.1 3.7 3 1 0 3 3 3 0 Kelch motif BatA PF07584.11 EFE37655.1 - 0.25 11.7 0.2 0.47 10.8 0.2 1.4 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal DUF1658 PF07871.11 EFE37655.1 - 0.53 10.3 3.8 2 8.5 3.8 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1658) Pyr_redox_3 PF13738.6 EFE37657.1 - 0.00021 20.7 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE37657.1 - 0.091 11.9 0.0 0.6 9.2 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pkinase PF00069.25 EFE37658.1 - 3.7e-21 75.7 0.0 2e-09 37.2 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37658.1 - 2e-09 37.1 0.0 0.00078 18.8 0.1 3.7 3 1 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EFE37658.1 - 0.019 14.3 0.1 20 4.4 0.0 3.0 3 0 0 3 3 3 0 Kinase-like APH PF01636.23 EFE37658.1 - 0.047 13.6 0.1 0.29 11.0 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Arf PF00025.21 EFE37659.1 - 2.1e-39 134.8 0.0 7.6e-26 90.6 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EFE37659.1 - 2.5e-12 47.1 0.0 7.5e-12 45.5 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFE37659.1 - 3.4e-11 42.9 0.0 7.3e-05 22.1 0.0 2.7 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFE37659.1 - 1.2e-07 31.5 0.0 0.00058 19.5 0.0 2.3 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.23 EFE37659.1 - 3.2e-07 30.4 0.0 2.9e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFE37659.1 - 1e-06 28.3 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFE37659.1 - 1.1e-05 25.1 0.0 0.00027 20.6 0.0 2.2 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFE37659.1 - 1.5e-05 24.5 0.0 8.3e-05 22.1 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EFE37659.1 - 0.04 13.7 0.0 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 EFE37659.1 - 0.041 13.4 0.0 0.093 12.2 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF4630 PF15443.6 EFE37659.1 - 0.081 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4630) AAA_24 PF13479.6 EFE37659.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.5 2 0 0 2 2 2 0 AAA domain PIGA PF08288.12 EFE37660.1 - 3e-28 98.2 0.9 3e-28 98.2 0.9 1.9 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.20 EFE37660.1 - 5.6e-26 91.1 0.0 8.4e-26 90.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFE37660.1 - 3e-23 82.7 0.0 5.5e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFE37660.1 - 3.4e-16 59.7 0.0 6.2e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EFE37660.1 - 0.00072 19.9 0.0 0.003 17.9 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFE37660.1 - 0.022 15.2 0.0 0.039 14.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain DEAD PF00270.29 EFE37661.1 - 4.8e-36 124.2 0.1 6.7e-32 110.7 0.0 2.8 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE37661.1 - 1.6e-19 70.3 0.0 1.7e-18 67.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE37661.1 - 2.3e-07 31.0 0.0 1.9e-06 28.0 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFE37661.1 - 0.082 13.2 0.0 0.44 10.9 0.0 2.2 2 1 0 2 2 2 0 AAA domain UTP25 PF06862.12 EFE37661.1 - 0.11 11.2 0.0 3.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Macoilin PF09726.9 EFE37661.1 - 2.2 6.7 21.6 0.0054 15.4 3.7 2.1 2 0 0 2 2 2 0 Macoilin family Prp18 PF02840.15 EFE37662.1 - 6.7e-56 188.3 0.0 6.7e-56 188.3 0.0 1.9 2 1 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EFE37662.1 - 4.1e-12 45.4 2.5 4.1e-12 45.4 2.5 2.9 3 0 0 3 3 3 1 pre-mRNA processing factor 4 (PRP4) like CDC27 PF09507.10 EFE37662.1 - 0.057 12.8 22.1 0.097 12.0 22.1 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 MAJIN PF15077.6 EFE37662.1 - 2.5 7.8 10.5 4.2 7.1 10.5 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein SAP18 PF06487.12 EFE37663.1 - 2.5e-50 170.3 0.0 3.1e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Methyltr_RsmB-F PF01189.17 EFE37664.1 - 6.3e-18 65.2 0.0 1.2e-10 41.4 0.0 2.6 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Acetyltransf_1 PF00583.25 EFE37665.1 - 3.8e-10 40.0 0.0 4.7e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_5 PF13444.6 EFE37665.1 - 3.2e-07 31.0 0.0 5.7e-06 27.0 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE37665.1 - 1.8e-06 28.3 0.0 2.3e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFE37665.1 - 4e-05 23.7 0.0 6.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_10 PF13673.7 EFE37665.1 - 0.00016 21.6 0.0 0.00025 21.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFE37665.1 - 0.0004 21.1 0.0 0.00052 20.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE37665.1 - 0.0022 18.1 0.0 0.0026 17.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE37665.1 - 0.013 15.4 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_15 PF17013.5 EFE37665.1 - 0.029 13.8 0.0 0.059 12.8 0.0 1.5 1 1 0 1 1 1 0 Putative acetyl-transferase FYVE PF01363.21 EFE37666.1 - 8.5e-13 48.2 4.3 1.5e-12 47.5 4.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 EFE37666.1 - 0.087 13.0 9.3 0.18 12.0 9.3 1.5 1 0 0 1 1 1 0 AN1-like Zinc finger FAD_binding_3 PF01494.19 EFE37668.1 - 1.9e-11 43.9 0.1 7.7e-08 32.0 0.0 2.7 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.24 EFE37668.1 - 3.2e-05 23.7 0.0 0.00013 21.7 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE37668.1 - 6.8e-05 23.0 0.0 0.00015 21.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE37668.1 - 7.2e-05 22.2 0.1 0.14 11.4 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFE37668.1 - 0.0002 20.4 0.0 0.034 13.0 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase SE PF08491.10 EFE37668.1 - 0.0047 16.0 0.0 0.011 14.8 0.0 1.6 1 1 0 1 1 1 1 Squalene epoxidase NAD_binding_9 PF13454.6 EFE37668.1 - 0.0056 16.7 0.0 0.045 13.8 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding IDO PF01231.18 EFE37669.1 - 0.00061 18.7 0.0 0.0018 17.1 0.0 1.6 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase Prok_Ub PF14454.6 EFE37669.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic Ubiquitin DUF1970 PF09301.10 EFE37669.1 - 0.16 12.2 0.0 0.55 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1970) ABC2_membrane PF01061.24 EFE37670.1 - 1e-70 237.4 57.6 5.3e-38 130.6 17.5 3.6 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EFE37670.1 - 4.8e-40 137.3 0.0 1.8e-18 67.4 0.0 3.5 4 0 0 4 4 4 2 ABC transporter PDR_CDR PF06422.12 EFE37670.1 - 5.6e-31 106.3 11.9 2e-26 91.7 0.0 3.7 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EFE37670.1 - 2.5e-15 56.8 0.0 5.9e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_33 PF13671.6 EFE37670.1 - 1.7e-07 31.5 0.2 0.0028 17.8 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EFE37670.1 - 2.4e-06 27.2 0.0 5e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFE37670.1 - 3.6e-06 26.6 0.5 0.0031 17.2 0.1 3.0 3 0 0 3 3 3 1 P-loop containing region of AAA domain SMC_N PF02463.19 EFE37670.1 - 1.2e-05 24.9 0.0 0.096 12.1 0.0 3.6 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFE37670.1 - 1.7e-05 24.8 0.1 0.23 11.3 0.1 3.0 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFE37670.1 - 2.9e-05 23.4 16.5 2.9e-05 23.4 16.5 3.7 4 0 0 4 4 4 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFE37670.1 - 4.3e-05 23.5 0.1 0.0016 18.4 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EFE37670.1 - 5.2e-05 23.7 0.2 0.002 18.5 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EFE37670.1 - 5.5e-05 23.7 0.0 0.00082 19.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EFE37670.1 - 0.0015 19.1 0.0 0.073 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFE37670.1 - 0.0019 18.3 0.1 2.8 8.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase cobW PF02492.19 EFE37670.1 - 0.0044 16.6 0.6 0.036 13.6 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EFE37670.1 - 0.0082 16.1 1.4 1.3 9.0 0.3 2.7 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EFE37670.1 - 0.012 15.9 1.0 0.44 10.8 0.2 3.1 3 1 0 3 3 2 0 AAA domain AAA PF00004.29 EFE37670.1 - 0.027 14.9 0.1 4.5 7.7 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC2_membrane_2 PF12679.7 EFE37670.1 - 0.035 13.4 18.8 0.011 15.0 8.9 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein AAA_17 PF13207.6 EFE37670.1 - 0.045 14.2 0.3 0.55 10.7 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_30 PF13604.6 EFE37670.1 - 0.045 13.5 0.1 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFE37670.1 - 0.062 13.7 0.0 26 5.3 0.0 2.9 2 0 0 2 2 2 0 RNA helicase Pax2_C PF12403.8 EFE37670.1 - 0.087 12.9 0.5 0.37 10.9 0.4 2.1 1 1 1 2 2 2 0 Paired-box protein 2 C terminal AAA_28 PF13521.6 EFE37670.1 - 0.16 12.2 0.2 0.39 10.9 0.2 1.6 1 0 0 1 1 1 0 AAA domain RPAP1_C PF08620.10 EFE37671.1 - 1e-23 83.2 0.0 1.8e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EFE37671.1 - 4.5e-15 55.2 8.2 9.2e-15 54.2 8.2 1.6 1 0 0 1 1 1 1 RPAP1-like, N-terminal GUCT PF08152.12 EFE37671.1 - 0.17 12.2 0.2 0.45 10.8 0.2 1.6 1 0 0 1 1 1 0 GUCT (NUC152) domain HUN PF08729.10 EFE37672.1 - 1e-07 31.8 0.0 2.7e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 HPC2 and ubinuclein domain MFS_1 PF07690.16 EFE37673.1 - 2.1e-14 53.2 12.9 2.8e-13 49.6 10.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.11 EFE37673.1 - 0.063 13.6 7.7 0.36 11.1 2.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) Fungal_trans_2 PF11951.8 EFE37674.1 - 2.9e-17 62.6 0.1 5.8e-17 61.6 0.1 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.8 EFE37675.1 - 3.4e-28 98.6 0.0 4.4e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain ANAPC1 PF12859.7 EFE37676.1 - 1.2e-31 110.0 1.1 1.2e-31 110.0 1.1 3.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EFE37676.1 - 0.00053 20.3 8.7 0.012 16.0 0.1 4.6 5 0 0 5 5 5 1 Proteasome/cyclosome repeat PIP5K PF01504.18 EFE37678.1 - 6.3e-101 337.2 0.1 6.3e-101 337.2 0.1 2.3 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Pkinase PF00069.25 EFE37679.1 - 7.8e-20 71.3 0.1 1e-13 51.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Kinase-like PF14531.6 EFE37679.1 - 7.9e-06 25.4 0.0 0.013 14.8 0.0 2.8 3 0 0 3 3 3 2 Kinase-like Pkinase_Tyr PF07714.17 EFE37679.1 - 1.8e-05 24.2 0.1 4.3e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE37679.1 - 0.01 15.8 0.0 0.046 13.6 0.1 1.9 1 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE37679.1 - 0.017 13.9 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EFE37679.1 - 0.024 14.0 0.1 0.061 12.7 0.1 1.8 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EFE37680.1 - 5.4e-21 75.1 0.0 2.4e-16 59.9 0.0 3.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37680.1 - 1.3e-06 27.9 2.6 0.0039 16.5 0.0 3.8 3 1 1 4 4 4 3 Protein tyrosine kinase F-box-like PF12937.7 EFE37681.1 - 0.002 18.0 0.1 0.008 16.1 0.1 2.1 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFE37681.1 - 0.017 15.0 0.0 0.031 14.2 0.0 1.5 1 0 0 1 1 1 0 F-box Linker_histone PF00538.19 EFE37683.1 - 3.1e-20 72.3 0.6 3.1e-20 72.3 0.6 2.9 2 1 0 2 2 2 1 linker histone H1 and H5 family SAPS PF04499.15 EFE37683.1 - 0.16 10.8 5.8 0.19 10.5 5.8 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SRP-alpha_N PF04086.13 EFE37683.1 - 0.93 9.4 32.7 1.5 8.7 32.7 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDC45 PF02724.14 EFE37684.1 - 0.23 9.7 3.4 0.22 9.8 3.4 1.1 1 0 0 1 1 1 0 CDC45-like protein XPG_I PF00867.18 EFE37686.1 - 4.8e-30 103.8 1.1 2.2e-29 101.6 0.0 2.4 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EFE37686.1 - 5.4e-17 62.1 1.0 3.2e-15 56.4 0.0 2.9 2 1 1 3 3 3 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EFE37686.1 - 0.00011 22.7 0.7 0.00044 20.8 0.0 2.2 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HXXSHH PF07586.11 EFE37686.1 - 0.24 10.9 6.4 0.05 13.2 2.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1552) Ras PF00071.22 EFE37687.1 - 3.8e-44 150.1 0.2 5.5e-44 149.6 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE37687.1 - 6.3e-10 39.3 0.0 1.1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFE37687.1 - 0.00039 20.0 0.0 0.0013 18.3 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFE37687.1 - 0.012 15.0 0.1 0.017 14.6 0.1 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 EFE37687.1 - 0.015 15.3 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 EFE37687.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B Cadherin_C_2 PF16492.5 EFE37687.1 - 0.2 12.4 0.1 0.2 12.4 0.1 3.3 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal 7tm_1 PF00001.21 EFE37687.1 - 0.63 9.3 7.4 2.8 7.2 6.0 2.1 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) adh_short PF00106.25 EFE37688.1 - 1.1e-51 175.0 0.1 1.4e-51 174.8 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE37688.1 - 3.6e-34 118.4 0.0 4.1e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE37688.1 - 3.3e-12 46.7 0.0 4.5e-12 46.2 0.0 1.2 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFE37688.1 - 7.2e-05 22.1 0.2 9.9e-05 21.6 0.2 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EFE37688.1 - 0.015 15.6 0.1 0.024 14.9 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EFE37688.1 - 0.023 14.2 0.1 0.029 13.8 0.1 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Lin0512_fam PF09585.10 EFE37688.1 - 0.051 13.6 0.6 0.69 10.0 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein (Lin0512_fam) Eno-Rase_NADH_b PF12242.8 EFE37688.1 - 0.11 12.3 0.1 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF1776 PF08643.10 EFE37688.1 - 0.16 11.4 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) GATA PF00320.27 EFE37690.1 - 1.2e-15 56.8 4.8 2.2e-15 56.0 4.8 1.5 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 EFE37690.1 - 0.0079 15.7 0.8 0.016 14.7 0.8 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Roughex PF06020.11 EFE37690.1 - 0.017 14.2 8.9 0.032 13.4 8.9 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Zn-ribbon_8 PF09723.10 EFE37690.1 - 0.073 13.2 0.1 0.073 13.2 0.1 2.0 2 0 0 2 2 2 0 Zinc ribbon domain Auto_anti-p27 PF06677.12 EFE37690.1 - 0.13 12.4 0.9 0.26 11.5 0.9 1.5 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-Sec23_Sec24 PF04810.15 EFE37690.1 - 0.86 9.7 5.5 0.14 12.2 1.0 1.9 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger RR_TM4-6 PF06459.12 EFE37690.1 - 1.3 8.8 4.8 3.9 7.2 4.8 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TERB2 PF15101.6 EFE37690.1 - 3.9 7.5 9.0 10 6.1 9.0 1.7 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DAO PF01266.24 EFE37691.1 - 9.7e-34 117.5 0.2 1.1e-33 117.3 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE37691.1 - 0.00071 19.8 0.1 0.0016 18.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFE37691.1 - 0.0035 17.9 0.0 0.0081 16.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFE37691.1 - 0.024 13.9 0.1 0.046 12.9 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EFE37691.1 - 0.032 14.5 0.2 0.092 13.0 0.1 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.17 EFE37691.1 - 0.046 12.9 0.1 0.046 12.9 0.1 1.6 2 0 0 2 2 2 0 Thi4 family ApbA PF02558.16 EFE37691.1 - 0.068 12.8 0.5 0.46 10.1 0.2 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 EFE37691.1 - 0.082 13.4 0.0 0.14 12.6 0.0 1.5 1 1 0 1 1 1 0 Putative NAD(P)-binding DUF1188 PF06690.11 EFE37691.1 - 0.092 12.3 0.1 7.5 6.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) GMC_oxred_N PF00732.19 EFE37691.1 - 0.1 11.9 0.0 0.31 10.4 0.0 1.8 2 0 0 2 2 2 0 GMC oxidoreductase Glyco_transf_54 PF04666.13 EFE37693.1 - 3.9e-07 29.2 0.0 0.00042 19.3 0.0 3.0 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glyco_transf_25 PF01755.17 EFE37693.1 - 0.021 14.7 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Type_ISP_C PF18135.1 EFE37693.1 - 0.024 13.6 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 Type ISP C-terminal specificity domain OTU PF02338.19 EFE37694.1 - 4.9e-13 49.7 0.0 7.9e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease CUE PF02845.16 EFE37694.1 - 0.0057 16.3 0.3 0.02 14.6 0.0 2.0 3 0 0 3 3 3 1 CUE domain YqcI_YcgG PF08892.11 EFE37695.1 - 2.5e-67 226.8 0.1 3.3e-67 226.4 0.1 1.2 1 0 0 1 1 1 1 YqcI/YcgG family MFS_1 PF07690.16 EFE37696.1 - 1.8e-19 69.9 41.3 4.2e-18 65.4 32.9 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE37696.1 - 8.1e-06 25.0 4.4 1.6e-05 24.0 4.4 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter zf-ANAPC11 PF12861.7 EFE37697.1 - 0.00043 20.3 2.0 0.00055 19.9 2.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EFE37697.1 - 0.029 14.7 1.6 0.046 14.0 1.6 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain PNRC PF15365.6 EFE37698.1 - 1e-08 34.8 7.7 1e-08 34.8 7.7 4.6 4 0 0 4 4 4 1 Proline-rich nuclear receptor coactivator motif UPF0370 PF13980.6 EFE37700.1 - 0.0081 16.2 0.9 0.12 12.4 0.2 2.6 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0370) HKR_ArcB_TM PF18415.1 EFE37700.1 - 0.032 15.0 3.3 0.032 15.0 3.3 2.4 2 0 0 2 2 2 0 Histidine kinase receptor ArcB trans-membrane domain EptA_B_N PF08019.12 EFE37700.1 - 8.6 6.2 16.5 0.44 10.4 1.5 3.0 2 1 1 3 3 3 0 Phosphoethanolamine transferase EptA/EptB Git3 PF11710.8 EFE37703.1 - 7.8e-28 97.6 6.5 1.5e-27 96.7 6.5 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EFE37703.1 - 2.3e-10 40.4 2.5 2.7e-10 40.2 0.1 2.4 3 0 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 EFE37703.1 - 3.1e-05 23.4 4.8 5.6e-05 22.6 4.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.11 EFE37703.1 - 0.011 14.9 4.5 0.011 14.9 3.4 1.5 1 1 0 1 1 1 0 Slime mold cyclic AMP receptor Velvet PF11754.8 EFE37704.1 - 4.9e-51 174.1 0.1 6.1e-51 173.8 0.1 1.0 1 0 0 1 1 1 1 Velvet factor RTA1 PF04479.13 EFE37707.1 - 1.2e-65 221.0 3.0 2.1e-65 220.2 3.0 1.4 1 0 0 1 1 1 1 RTA1 like protein CBP_BcsF PF11120.8 EFE37707.1 - 0.012 15.7 0.2 0.03 14.4 0.2 1.6 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF DUF3493 PF11998.8 EFE37707.1 - 0.092 12.9 0.2 0.33 11.2 0.1 2.0 1 1 0 1 1 1 0 Low psii accumulation1 / Rep27 DUF4013 PF13197.6 EFE37707.1 - 3.9 7.3 10.3 0.86 9.4 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4013) Fer2_3 PF13085.6 EFE37708.1 - 1.3e-32 112.1 0.1 2.1e-32 111.4 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EFE37708.1 - 1e-08 35.6 5.7 1e-08 35.6 5.7 2.2 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EFE37708.1 - 1.9e-07 31.4 6.3 1.9e-07 31.4 6.3 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFE37708.1 - 8.7e-07 29.0 2.5 8.7e-07 29.0 2.5 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EFE37708.1 - 0.002 18.7 4.2 0.002 18.7 4.2 2.5 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EFE37708.1 - 0.005 16.8 0.4 0.005 16.8 0.4 2.2 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain SF3a60_bindingd PF12108.8 EFE37708.1 - 0.17 11.8 0.2 0.27 11.2 0.2 1.3 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain F_bP_aldolase PF01116.20 EFE37709.1 - 3.5e-84 282.6 0.0 3.9e-84 282.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II OrfB_IS605 PF01385.19 EFE37709.1 - 0.042 14.1 0.1 0.15 12.2 0.0 1.9 2 0 0 2 2 2 0 Probable transposase NAD_binding_11 PF14833.6 EFE37710.1 - 7.2e-43 145.7 0.1 3e-28 98.5 0.0 2.2 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 EFE37710.1 - 1.1e-35 123.2 0.0 1.8e-35 122.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EFE37710.1 - 0.0012 18.8 0.1 0.0021 18.0 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EFE37710.1 - 0.0073 16.9 0.0 0.027 15.1 0.0 2.0 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EFE37710.1 - 0.0091 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EFE37710.1 - 0.018 14.7 0.1 0.036 13.7 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Helicase_C PF00271.31 EFE37715.1 - 7.1e-31 106.8 0.0 3.8e-30 104.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE37715.1 - 7.2e-15 55.2 1.1 5.1e-13 49.2 0.1 2.5 2 1 1 3 3 3 2 DEAD/DEAH box helicase Rhomboid_N PF12122.8 EFE37715.1 - 0.028 14.6 0.0 7.9 6.7 0.0 2.6 2 0 0 2 2 2 0 Cytoplasmic N-terminal domain of rhomboid serine protease APH PF01636.23 EFE37716.1 - 3.5e-14 53.3 0.0 5e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE37716.1 - 0.1 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 EFE37716.1 - 0.22 10.7 0.0 1 8.5 0.0 1.8 2 0 0 2 2 2 0 Fructosamine kinase tRNA_lig_CPD PF08302.11 EFE37719.1 - 9.8e-93 310.2 0.4 1.4e-92 309.7 0.4 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RNA_lig_T4_1 PF09511.10 EFE37719.1 - 5.4e-84 281.4 2.4 5.4e-84 281.4 0.0 2.1 3 0 0 3 3 3 1 RNA ligase tRNA_lig_kinase PF08303.11 EFE37719.1 - 4.4e-49 166.8 0.2 1.1e-48 165.4 0.1 1.8 2 0 0 2 2 2 1 tRNA ligase kinase domain AAA_23 PF13476.6 EFE37719.1 - 0.0015 19.1 0.4 0.0038 17.8 0.4 1.7 1 0 0 1 1 1 1 AAA domain Tim54 PF11711.8 EFE37719.1 - 0.0068 15.2 1.5 0.01 14.6 1.5 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 CotH PF08757.11 EFE37719.1 - 0.01 15.4 0.4 0.01 15.4 0.4 1.6 2 0 0 2 2 2 0 CotH kinase protein SUIM_assoc PF16619.5 EFE37719.1 - 0.029 14.4 8.8 0.11 12.6 2.0 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF3217 PF11506.8 EFE37719.1 - 0.035 14.1 0.1 12 5.9 0.0 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3217) LPP20 PF02169.16 EFE37719.1 - 0.087 13.2 2.2 0.96 9.8 0.5 3.0 3 0 0 3 3 3 0 LPP20 lipoprotein AAA_18 PF13238.6 EFE37719.1 - 0.25 11.9 4.0 0.36 11.4 0.1 3.3 4 1 0 4 4 4 0 AAA domain DEAD PF00270.29 EFE37720.1 - 4.1e-22 78.8 0.0 9.5e-22 77.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE37720.1 - 2.1e-21 76.4 0.0 2.6e-17 63.2 0.0 3.0 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EFE37720.1 - 6.6e-14 52.4 8.9 6.6e-14 52.4 8.9 2.3 2 0 0 2 2 2 1 RecQ zinc-binding RQC PF09382.10 EFE37720.1 - 1.2e-13 50.8 0.0 3e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 RQC domain ResIII PF04851.15 EFE37720.1 - 2e-06 27.9 0.0 5.1e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF86 PF01934.17 EFE37720.1 - 5.2 6.9 5.5 1.5 8.7 0.4 2.6 3 0 0 3 3 3 0 Protein of unknown function DUF86 DUF4110 PF13422.6 EFE37721.1 - 1.3e-32 111.7 0.2 1.3e-32 111.7 0.2 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4110) Kelch_4 PF13418.6 EFE37721.1 - 8e-27 93.0 10.0 4.4e-10 39.4 0.0 6.5 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EFE37721.1 - 1.2e-24 86.0 10.2 2.9e-09 37.0 0.1 6.4 8 0 0 8 8 8 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFE37721.1 - 1.3e-16 60.1 2.8 7.9e-06 25.7 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 EFE37721.1 - 1.9e-15 56.5 5.4 0.00025 21.2 0.1 5.2 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EFE37721.1 - 4.2e-13 48.7 5.3 1.3e-05 24.7 0.0 4.3 3 1 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 EFE37721.1 - 3.4e-12 45.8 5.0 0.00092 19.1 0.0 6.0 6 1 0 6 6 6 3 Kelch motif Pyridoxal_deC PF00282.19 EFE37722.1 - 7.3e-24 84.2 0.0 3.3e-22 78.7 0.0 2.1 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EFE37722.1 - 0.12 11.6 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Glyco_hydro_61 PF03443.14 EFE37723.1 - 0.00039 20.4 0.0 0.0046 16.9 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 CENP-B_dimeris PF09026.10 EFE37724.1 - 0.065 13.6 2.8 0.07 13.5 2.8 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GCIP PF13324.6 EFE37724.1 - 0.2 11.2 0.5 0.22 11.1 0.5 1.0 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting CUE PF02845.16 EFE37727.1 - 2.5e-10 39.9 0.0 4.3e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 CUE domain ELK PF03789.13 EFE37727.1 - 0.0062 16.6 0.2 0.011 15.8 0.2 1.3 1 0 0 1 1 1 1 ELK domain RTA1 PF04479.13 EFE37728.1 - 4.1e-46 157.2 13.9 1.1e-45 155.7 9.7 2.5 2 1 0 2 2 2 1 RTA1 like protein Oxysterol_BP PF01237.18 EFE37729.1 - 1.3e-64 218.3 2.5 2e-62 211.2 2.5 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein SbsC_C PF18058.1 EFE37729.1 - 0.11 12.8 0.8 0.16 12.2 0.1 1.6 2 0 0 2 2 2 0 SbsC C-terminal domain Suf PF05843.14 EFE37730.1 - 8.3e-96 321.4 0.0 8.3e-96 321.4 0.0 4.5 4 1 1 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EFE37730.1 - 2.3e-05 24.8 0.1 0.023 15.5 0.0 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat HAT PF02184.16 EFE37730.1 - 0.00072 19.5 0.1 0.0031 17.4 0.1 2.2 1 0 0 1 1 1 1 HAT (Half-A-TPR) repeat TPR_16 PF13432.6 EFE37730.1 - 0.0036 17.9 0.0 0.17 12.6 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Cdh1_DBD_1 PF18196.1 EFE37730.1 - 0.45 10.9 3.5 1.1 9.6 3.5 1.6 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 ASF1_hist_chap PF04729.13 EFE37731.1 - 9.7e-63 210.7 0.0 1.5e-62 210.1 0.0 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.12 EFE37731.1 - 1.6 6.8 23.0 2.1 6.5 23.0 1.0 1 0 0 1 1 1 0 Nop14-like family Nop53 PF07767.11 EFE37731.1 - 7.9 5.7 14.8 11 5.2 14.8 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Pex19 PF04614.12 EFE37732.1 - 4.1e-70 236.3 19.5 4.1e-70 236.3 19.5 2.0 1 1 1 2 2 2 1 Pex19 protein family DUF4327 PF14217.6 EFE37732.1 - 0.0061 16.7 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4327) Gluconate_2-dh3 PF13618.6 EFE37732.1 - 0.16 12.2 10.4 77 3.5 10.4 3.1 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 CENP-H PF05837.12 EFE37734.1 - 4.9e-27 94.6 9.1 4.9e-27 94.6 9.1 2.2 2 1 0 2 2 2 1 Centromere protein H (CENP-H) SOAR PF16533.5 EFE37734.1 - 0.016 15.1 6.1 0.12 12.3 4.2 2.3 1 1 1 2 2 2 0 STIM1 Orai1-activating region Cas_DxTHG PF09455.10 EFE37734.1 - 0.5 9.9 6.4 0.3 10.6 4.9 1.4 1 1 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family TSC22 PF01166.18 EFE37734.1 - 7.2 7.0 9.5 5.2 7.5 0.4 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family ATG11 PF10377.9 EFE37735.1 - 4.7e-45 152.8 0.1 4.7e-45 152.8 0.1 4.0 5 0 0 5 5 5 1 Autophagy-related protein 11 APG17 PF04108.12 EFE37735.1 - 6.6e-09 35.4 1.0 7.4e-07 28.6 0.0 4.5 4 1 0 4 4 4 2 Autophagy protein Apg17 ERM PF00769.19 EFE37735.1 - 8.3e-05 22.5 17.5 8.3e-05 22.5 17.5 5.6 4 1 0 5 5 5 1 Ezrin/radixin/moesin family KIAA1430 PF13879.6 EFE37735.1 - 0.011 16.5 2.0 0.011 16.5 2.0 4.1 3 0 0 3 3 3 0 KIAA1430 homologue AAA_33 PF13671.6 EFE37735.1 - 0.057 13.6 0.6 5 7.3 0.1 3.5 2 0 0 2 2 2 0 AAA domain Vps51 PF08700.11 EFE37735.1 - 2.3 8.3 12.6 1.2 9.2 2.1 5.1 3 1 0 3 3 3 0 Vps51/Vps67 HEPN_Apea PF18739.1 EFE37735.1 - 7.6 7.0 10.2 44 4.6 0.0 4.7 4 1 0 4 4 4 0 Apea-like HEPN DUF4078 PF13300.6 EFE37736.1 - 2.1e-28 98.5 10.3 2.1e-28 98.5 10.3 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) Homoserine_dh PF00742.19 EFE37737.1 - 6.4e-52 176.0 0.0 8.3e-52 175.6 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EFE37737.1 - 2.7e-13 50.6 0.0 8.3e-13 49.0 0.0 1.9 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain RecO_N PF11967.8 EFE37737.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Recombination protein O N terminal p450 PF00067.22 EFE37738.1 - 7.4e-38 130.5 0.0 1.2e-37 129.8 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 O_Spanin_T7 PF17531.2 EFE37738.1 - 0.089 12.8 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 outer-membrane spanin sub-unit DEAD PF00270.29 EFE37740.1 - 7.1e-47 159.4 0.0 1.5e-46 158.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Ribosomal_L22 PF00237.19 EFE37740.1 - 4.6e-28 97.5 0.0 1.2e-27 96.1 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF4217 PF13959.6 EFE37740.1 - 2.1e-19 69.5 0.2 5.1e-19 68.3 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 EFE37740.1 - 5.7e-17 62.1 0.4 9.2e-16 58.2 0.0 3.1 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Oxysterol_BP PF01237.18 EFE37742.1 - 6.5e-44 150.3 0.1 6.5e-44 150.3 0.1 3.2 2 2 0 2 2 2 1 Oxysterol-binding protein Trypan_PARP PF05887.11 EFE37742.1 - 0.088 12.8 0.0 0.088 12.8 0.0 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Mucin PF01456.17 EFE37742.1 - 0.29 11.1 0.1 0.29 11.1 0.1 2.6 3 0 0 3 3 3 0 Mucin-like glycoprotein SARAF PF06682.12 EFE37742.1 - 0.32 10.6 0.0 0.32 10.6 0.0 3.9 4 1 1 5 5 5 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3439 PF11921.8 EFE37742.1 - 0.46 10.5 12.0 2.2 8.2 4.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Kelch_3 PF13415.6 EFE37742.1 - 6.1 7.3 0.0 6.1 7.3 0.0 3.1 3 0 0 3 3 3 0 Galactose oxidase, central domain Cnd1_N PF12922.7 EFE37743.1 - 6.3e-58 195.3 0.0 2.2e-57 193.6 0.0 2.0 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 EFE37743.1 - 1.2e-38 132.7 6.4 1.8e-34 119.1 0.6 3.9 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFE37743.1 - 1.1e-09 38.5 5.7 0.00015 22.1 0.0 4.9 5 1 1 6 6 6 3 HEAT repeats HEAT PF02985.22 EFE37743.1 - 6.3e-09 35.3 7.1 0.047 14.0 0.0 7.1 7 1 0 7 7 7 2 HEAT repeat Adaptin_N PF01602.20 EFE37743.1 - 2.9e-07 29.4 5.4 0.00035 19.3 0.2 4.1 4 0 0 4 4 4 2 Adaptin N terminal region RTP1_C1 PF10363.9 EFE37743.1 - 5.4e-06 26.6 0.5 0.76 10.0 0.0 4.7 3 1 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 EFE37743.1 - 4e-05 24.0 5.6 0.23 12.0 0.1 5.1 4 0 0 4 4 4 1 HEAT-like repeat Cnd3 PF12719.7 EFE37743.1 - 0.0041 16.4 6.4 0.0042 16.3 0.7 3.7 5 0 0 5 5 5 1 Nuclear condensing complex subunits, C-term domain VHS PF00790.19 EFE37743.1 - 0.079 12.8 1.1 4.4 7.1 0.0 3.3 3 0 0 3 3 3 0 VHS domain DUF3391 PF11871.8 EFE37743.1 - 7.1 7.2 6.0 2 9.0 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Pkinase PF00069.25 EFE37744.1 - 9.4e-40 136.6 0.0 1.3e-39 136.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37744.1 - 1.3e-12 47.6 0.0 7e-12 45.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE37744.1 - 0.00013 21.4 0.0 0.003 16.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFE37744.1 - 0.0031 17.5 0.2 0.14 12.1 0.0 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE37744.1 - 0.011 14.5 0.0 0.022 13.6 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 EFE37744.1 - 0.059 13.0 0.1 0.16 11.6 0.0 1.7 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PCMT PF01135.19 EFE37745.1 - 2.6e-48 164.6 0.0 9e-48 162.8 0.0 1.7 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EFE37745.1 - 1.6e-07 31.2 0.0 2.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE37745.1 - 1.9e-06 28.5 0.0 3.3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE37745.1 - 7e-06 26.0 0.0 9.5e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE37745.1 - 0.00041 21.0 0.0 0.00062 20.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFE37745.1 - 0.00048 20.2 0.0 0.00073 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFE37745.1 - 0.005 16.4 0.0 0.0079 15.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 EFE37745.1 - 0.0082 16.8 0.0 0.013 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EFE37745.1 - 0.0089 15.6 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 EFE37745.1 - 0.015 14.7 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EFE37745.1 - 0.037 13.3 0.0 0.059 12.6 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 EFE37745.1 - 0.15 11.0 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_24 PF13578.6 EFE37745.1 - 0.15 13.1 0.0 0.76 10.8 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain DnaJ PF00226.31 EFE37746.1 - 3.3e-22 78.4 0.5 1e-21 76.8 0.5 1.9 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 EFE37746.1 - 2.7e-19 67.6 0.0 0.00034 20.5 0.0 6.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFE37746.1 - 2.1e-17 62.1 0.6 9.8e-06 25.2 0.0 6.1 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 EFE37746.1 - 6.8e-17 61.4 0.1 3.2e-05 24.0 0.0 4.8 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFE37746.1 - 2.1e-12 46.8 0.2 0.086 13.7 0.1 6.9 3 3 4 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFE37746.1 - 3.8e-12 46.5 0.5 0.016 15.7 0.1 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFE37746.1 - 1.5e-11 43.6 0.0 0.016 15.3 0.0 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFE37746.1 - 1.8e-09 38.1 1.9 1.4e-05 25.6 0.1 4.4 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFE37746.1 - 3e-09 36.9 2.5 4.1 8.2 0.0 7.3 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE37746.1 - 7.1e-09 35.2 0.3 0.042 13.5 0.0 4.3 3 1 1 4 4 4 3 TPR repeat TPR_17 PF13431.6 EFE37746.1 - 3.5e-06 27.0 1.1 0.014 15.7 0.0 5.6 7 2 0 7 7 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE37746.1 - 3.1e-05 24.1 0.8 5.7 7.2 0.0 4.9 3 1 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EFE37746.1 - 0.00013 22.2 0.0 3.3 8.1 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFE37746.1 - 0.00086 19.2 0.0 26 5.2 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat PknG_TPR PF16918.5 EFE37746.1 - 0.00098 17.9 0.1 0.015 14.0 0.0 2.5 3 0 0 3 3 3 1 Protein kinase G tetratricopeptide repeat DUF3856 PF12968.7 EFE37746.1 - 0.019 15.0 1.2 5.6 7.0 0.0 3.6 5 0 0 5 5 4 0 Domain of Unknown Function (DUF3856) HrpB1_HrpK PF09613.10 EFE37746.1 - 0.055 13.1 0.0 8.3 6.1 0.0 3.2 4 0 0 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) RPT PF13446.6 EFE37746.1 - 0.19 11.7 1.1 3.5 7.6 0.0 3.3 5 0 0 5 5 5 0 A repeated domain in UCH-protein LMBR1 PF04791.16 EFE37746.1 - 1.1 8.0 2.3 2.5 6.9 1.7 1.7 2 0 0 2 2 2 0 LMBR1-like membrane protein PTS_IIA PF02255.16 EFE37746.1 - 1.5 8.9 7.0 13 6.0 2.6 2.8 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit PCRF PF03462.18 EFE37747.1 - 7.4e-49 166.3 0.4 2.1e-48 164.8 0.0 2.0 3 0 0 3 3 3 1 PCRF domain RF-1 PF00472.20 EFE37747.1 - 1.3e-33 115.3 1.0 1.3e-33 115.3 1.0 2.0 2 0 0 2 2 2 1 RF-1 domain Abdominal-A PF12407.8 EFE37747.1 - 0.77 9.4 9.1 1.6 8.4 9.1 1.5 1 0 0 1 1 1 0 Homeobox protein Mito_carr PF00153.27 EFE37748.1 - 1.9e-30 104.6 3.0 4.5e-16 58.6 0.2 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein DEAD PF00270.29 EFE37749.1 - 2.9e-42 144.4 0.2 4.2e-42 143.9 0.2 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE37749.1 - 7.7e-28 97.1 0.8 6.9e-27 94.0 0.4 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 EFE37749.1 - 0.011 15.1 0.1 0.024 14.0 0.1 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit USP7_ICP0_bdg PF12436.8 EFE37749.1 - 0.13 11.5 0.2 0.22 10.8 0.2 1.3 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 SMC_N PF02463.19 EFE37750.1 - 1.2e-16 60.8 0.0 8.5e-16 58.1 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFE37750.1 - 6.3e-15 56.2 9.4 6.3e-15 56.2 9.4 4.7 2 2 1 3 3 3 1 AAA domain AAA_15 PF13175.6 EFE37750.1 - 1.3e-11 44.8 1.0 1.3e-11 44.8 1.0 3.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EFE37750.1 - 5.1e-08 33.1 4.3 4.3e-05 23.5 0.1 3.5 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFE37750.1 - 0.00043 20.0 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 EFE37750.1 - 0.0077 16.4 0.0 0.026 14.8 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit APG6_N PF17675.1 EFE37750.1 - 0.011 16.2 7.9 0.011 16.2 7.9 6.5 4 2 3 7 7 7 0 Apg6 coiled-coil region ABC_tran PF00005.27 EFE37750.1 - 0.11 13.0 0.2 0.11 13.0 0.2 5.6 4 2 1 5 5 5 0 ABC transporter AAA_13 PF13166.6 EFE37750.1 - 1.3 7.5 61.3 0.7 8.5 9.1 4.4 3 1 1 4 4 4 0 AAA domain RsgA_GTPase PF03193.16 EFE37750.1 - 1.7 8.5 4.4 16 5.3 0.0 3.4 3 0 0 3 3 3 0 RsgA GTPase NUDIX PF00293.28 EFE37751.1 - 5.3e-13 49.1 0.9 1.1e-12 48.2 0.9 1.5 1 1 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 EFE37751.1 - 7.6e-05 22.7 0.4 0.0017 18.3 0.4 2.4 1 1 0 1 1 1 1 NUDIX domain Syntaxin-5_N PF11416.8 EFE37754.1 - 2.2e-10 39.5 0.4 5e-10 38.3 0.4 1.7 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain SNARE PF05739.19 EFE37754.1 - 2.8e-09 36.8 0.2 7.3e-09 35.5 0.2 1.7 1 0 0 1 1 1 1 SNARE domain KxDL PF10241.9 EFE37754.1 - 0.0018 18.5 2.6 0.56 10.5 0.1 3.2 3 0 0 3 3 3 2 Uncharacterized conserved protein Syntaxin PF00804.25 EFE37754.1 - 0.0064 16.2 2.0 0.025 14.3 0.1 2.4 2 0 0 2 2 2 1 Syntaxin MCPsignal PF00015.21 EFE37754.1 - 0.048 13.5 1.0 1 9.2 0.4 2.4 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain NPV_P10 PF05531.12 EFE37754.1 - 0.55 10.7 2.1 22 5.6 0.1 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein AAA_22 PF13401.6 EFE37755.1 - 0.034 14.4 0.1 10 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFE37755.1 - 0.037 14.4 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Trypan_PARP PF05887.11 EFE37755.1 - 0.056 13.4 1.4 1.2 9.1 2.7 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF4834 PF16118.5 EFE37755.1 - 0.081 13.9 2.1 0.21 12.6 2.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) ETRAMP PF09716.10 EFE37755.1 - 0.083 13.0 6.2 0.18 11.9 6.2 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Glyco_hydro_18 PF00704.28 EFE37756.1 - 7.6e-19 68.6 0.9 2.5e-18 66.9 0.9 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 adh_short PF00106.25 EFE37757.1 - 8.4e-33 113.5 0.1 1e-32 113.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE37757.1 - 8e-31 107.4 0.0 9.8e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE37757.1 - 6e-11 42.6 0.1 9.2e-11 42.0 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFE37757.1 - 8.4e-05 22.1 0.1 0.0035 16.8 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFE37757.1 - 0.0038 16.4 0.0 0.0054 15.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 EFE37757.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EFE37757.1 - 0.17 11.2 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Ion_trans_2 PF07885.16 EFE37758.1 - 3.8e-24 84.4 24.9 3.5e-14 52.5 7.6 3.3 3 1 0 3 3 3 2 Ion channel DUF2700 PF10912.8 EFE37758.1 - 0.51 10.4 5.6 0.14 12.2 1.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2700) GWT1 PF06423.12 EFE37758.1 - 5.7 7.0 7.9 35 4.5 3.6 2.9 2 1 0 2 2 2 0 GWT1 ATPgrasp_N PF18130.1 EFE37760.1 - 3.6e-18 65.9 0.2 7.5e-18 64.9 0.2 1.6 1 0 0 1 1 1 1 ATP-grasp N-terminal domain ATP-grasp_4 PF13535.6 EFE37760.1 - 3.5e-13 49.5 0.0 1.6e-12 47.3 0.0 2.1 1 1 1 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFE37760.1 - 1.8e-07 30.9 0.0 4.3e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EFE37760.1 - 0.00067 19.7 0.0 0.0046 17.0 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EFE37760.1 - 0.021 14.3 0.0 0.087 12.3 0.0 1.9 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain EccE PF11203.8 EFE37760.1 - 0.17 12.2 0.1 0.6 10.5 0.1 1.9 1 0 0 1 1 1 0 Putative type VII ESX secretion system translocon, EccE RTA1 PF04479.13 EFE37761.1 - 2.7e-64 216.6 7.5 2.7e-64 216.6 7.5 1.4 1 1 0 1 1 1 1 RTA1 like protein DHHC PF01529.20 EFE37761.1 - 0.4 10.8 11.2 0.77 9.9 0.8 3.1 3 0 0 3 3 3 0 DHHC palmitoyltransferase DUF3040 PF11239.8 EFE37761.1 - 0.59 10.4 5.8 3.1 8.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) DUF3433 PF11915.8 EFE37762.1 - 1.2e-30 105.7 26.0 6.1e-22 77.9 5.8 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) Pkinase PF00069.25 EFE37763.1 - 1.7e-17 63.6 0.0 9.6e-17 61.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37763.1 - 1.4e-10 40.9 0.3 3.2e-09 36.4 0.2 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE37763.1 - 0.0039 16.0 0.0 0.0045 15.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EFE37763.1 - 0.074 12.7 0.1 0.16 11.6 0.1 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DUF695 PF05117.12 EFE37764.1 - 0.05 13.8 0.0 0.059 13.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF695) Pkinase PF00069.25 EFE37765.1 - 3.7e-11 42.9 0.0 4.5e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37765.1 - 0.0027 17.0 0.1 0.0049 16.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TRAF_BIRC3_bd PF16673.5 EFE37766.1 - 0.036 13.8 1.0 0.066 13.0 1.0 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain Hep_59 PF07052.11 EFE37766.1 - 0.22 12.3 3.4 0.37 11.6 1.2 2.1 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 G-patch PF01585.23 EFE37767.1 - 9.9e-10 38.2 3.6 2.3e-09 37.0 3.6 1.6 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EFE37767.1 - 1.6e-08 34.2 0.0 0.00017 21.4 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 EFE37767.1 - 0.00023 21.2 2.9 0.00082 19.4 2.9 2.0 1 0 0 1 1 1 1 G-patch domain Rad50_zn_hook PF04423.14 EFE37767.1 - 0.034 14.0 0.2 0.1 12.4 0.2 1.8 1 0 0 1 1 1 0 Rad50 zinc hook motif TFIIA PF03153.13 EFE37767.1 - 0.57 10.1 14.8 0.99 9.3 14.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ABC_tran PF00005.27 EFE37769.1 - 3.3e-51 173.4 0.0 8.2e-31 107.3 0.0 2.8 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFE37769.1 - 2.6e-17 63.4 5.5 2.6e-17 63.4 5.5 3.8 3 1 1 4 4 4 1 ABC transporter transmembrane region SMC_N PF02463.19 EFE37769.1 - 3e-08 33.4 3.0 0.0052 16.2 0.1 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFE37769.1 - 4.1e-07 29.6 0.6 0.024 14.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 EFE37769.1 - 5.2e-06 26.7 5.7 0.00051 20.2 0.3 3.0 3 0 0 3 3 3 2 Helicase HerA, central domain AAA_22 PF13401.6 EFE37769.1 - 6.5e-06 26.5 0.7 0.14 12.4 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFE37769.1 - 1.1e-05 25.9 0.1 0.12 12.7 0.0 3.0 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EFE37769.1 - 8.7e-05 22.5 0.5 0.4 10.4 0.2 3.5 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFE37769.1 - 8.8e-05 22.5 1.8 0.33 10.8 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFE37769.1 - 0.00013 22.0 0.1 0.21 11.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EFE37769.1 - 0.00026 21.6 0.6 0.42 11.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EFE37769.1 - 0.00055 20.0 0.1 0.18 11.9 0.0 2.4 2 0 0 2 2 2 1 Dynamin family AAA_25 PF13481.6 EFE37769.1 - 0.00063 19.4 0.1 0.72 9.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EFE37769.1 - 0.0016 18.2 0.2 0.79 9.4 0.0 3.2 3 0 0 3 3 3 1 AAA domain FtsK_SpoIIIE PF01580.18 EFE37769.1 - 0.0016 17.9 2.1 0.84 8.9 0.2 2.7 2 1 1 3 3 3 2 FtsK/SpoIIIE family AAA_7 PF12775.7 EFE37769.1 - 0.0022 17.5 0.1 0.22 11.0 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 EFE37769.1 - 0.003 18.1 0.0 4.7 7.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 EFE37769.1 - 0.0031 16.6 0.2 1.9 7.4 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_33 PF13671.6 EFE37769.1 - 0.0044 17.2 0.1 3 8.0 0.2 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EFE37769.1 - 0.017 14.4 0.1 5.4 6.2 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin SNARE PF05739.19 EFE37769.1 - 0.026 14.5 0.2 0.56 10.2 0.0 3.0 2 0 0 2 2 2 0 SNARE domain AAA PF00004.29 EFE37769.1 - 0.028 14.9 0.6 21 5.5 0.0 4.0 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EFE37769.1 - 0.028 14.1 1.0 1.1 8.9 0.1 2.6 3 0 0 3 3 3 0 AAA ATPase domain cobW PF02492.19 EFE37769.1 - 0.035 13.7 1.2 1.8 8.1 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF815 PF05673.13 EFE37769.1 - 0.04 13.1 0.2 2.7 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 EFE37769.1 - 0.043 13.0 0.0 3.1 6.9 0.0 2.5 2 1 0 2 2 2 0 NB-ARC domain SbcCD_C PF13558.6 EFE37769.1 - 0.047 13.9 0.1 9 6.6 0.0 2.7 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Viral_helicase1 PF01443.18 EFE37769.1 - 0.06 13.1 1.2 5.8 6.6 0.0 3.1 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 EFE37769.1 - 0.061 13.7 0.1 8.6 6.8 0.0 2.7 2 0 0 2 2 2 0 RNA helicase ATPase_2 PF01637.18 EFE37769.1 - 0.14 12.1 0.1 7.9 6.3 0.0 2.5 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea CUT PF02376.15 EFE37769.1 - 0.16 12.2 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 CUT domain TrwB_AAD_bind PF10412.9 EFE37769.1 - 0.18 10.7 1.3 12 4.7 0.2 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain dNK PF01712.19 EFE37769.1 - 0.26 11.1 0.7 7.5 6.3 0.1 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase Phage_holin_8 PF16931.5 EFE37769.1 - 1.4 8.9 5.5 41 4.2 0.1 3.8 3 0 0 3 3 3 0 Putative phage holin DUF3040 PF11239.8 EFE37769.1 - 2.6 8.4 8.7 11 6.4 0.0 4.9 5 0 0 5 5 4 0 Protein of unknown function (DUF3040) DUF4106 PF13388.6 EFE37770.1 - 0.16 11.2 1.3 0.24 10.6 1.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4106) AMP-binding PF00501.28 EFE37771.1 - 8.7e-157 522.0 0.0 4.9e-72 242.8 0.0 3.7 4 0 0 4 4 4 3 AMP-binding enzyme Condensation PF00668.20 EFE37771.1 - 6e-99 331.8 0.0 2.6e-29 102.2 0.0 5.4 5 0 0 5 5 5 5 Condensation domain PP-binding PF00550.25 EFE37771.1 - 5.8e-25 87.4 0.1 4e-13 49.5 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site IncF PF17626.2 EFE37771.1 - 0.021 15.2 0.6 5.1 7.5 0.0 3.0 2 0 0 2 2 2 0 Inclusion membrane protein F Amidase PF01425.21 EFE37772.1 - 9.3e-35 120.4 0.5 1.6e-34 119.6 0.1 1.5 2 0 0 2 2 2 1 Amidase Amino_oxidase PF01593.24 EFE37773.1 - 2.7e-34 119.3 0.1 3.2e-34 119.0 0.1 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFE37773.1 - 5.7e-06 26.5 0.0 1.3e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFE37773.1 - 0.077 12.2 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFE37773.1 - 0.078 12.5 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase ARL2_Bind_BART PF11527.8 EFE37773.1 - 0.088 12.9 0.2 0.19 11.8 0.2 1.5 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART FAD_binding_3 PF01494.19 EFE37773.1 - 0.14 11.4 0.2 0.26 10.5 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 EFE37773.1 - 0.16 11.2 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_1 PF00561.20 EFE37774.1 - 5.4e-10 39.4 0.1 4e-09 36.5 0.0 2.3 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EFE37774.1 - 8.8e-09 35.4 0.0 1.6e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Beta-lactamase PF00144.24 EFE37775.1 - 4.3e-43 147.8 0.0 6.2e-43 147.3 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 EFE37775.1 - 8.2e-10 39.1 0.0 1.9e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Ank_2 PF12796.7 EFE37776.1 - 6.2e-38 129.3 0.0 6.6e-13 49.1 0.0 4.0 2 1 2 4 4 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE37776.1 - 5.6e-34 116.1 0.6 9.1e-09 35.7 0.0 5.4 3 2 3 6 6 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EFE37776.1 - 1.3e-33 113.9 0.1 2.2e-07 31.0 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 EFE37776.1 - 3.7e-31 103.7 0.0 5.3e-06 26.4 0.0 7.0 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 EFE37776.1 - 3.5e-30 103.7 0.9 2e-10 40.7 0.0 6.2 2 1 5 7 7 6 6 Ankyrin repeats (many copies) NACHT PF05729.12 EFE37776.1 - 8.7e-12 45.3 0.0 2.1e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFE37776.1 - 6.1e-05 23.5 0.0 0.00026 21.4 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EFE37776.1 - 0.0033 16.7 0.0 0.008 15.4 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 EFE37776.1 - 0.0058 16.8 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFE37776.1 - 0.029 14.6 0.0 0.092 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFE37776.1 - 0.045 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA PF00004.29 EFE37776.1 - 0.068 13.6 0.0 0.22 11.9 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EFE37776.1 - 0.094 13.0 0.0 2.6 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFE37776.1 - 0.16 11.3 0.3 0.47 9.7 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin APH PF01636.23 EFE37778.1 - 1.1e-10 41.9 0.1 1.4e-09 38.2 0.0 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFE37778.1 - 7.4e-06 25.5 0.1 0.00048 19.5 0.0 2.1 2 0 0 2 2 2 2 Ecdysteroid kinase Choline_kinase PF01633.20 EFE37778.1 - 0.00021 20.9 0.0 0.00039 20.1 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EFE37778.1 - 0.0066 15.4 0.0 0.026 13.4 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) PI3_PI4_kinase PF00454.27 EFE37778.1 - 0.063 13.1 0.2 0.65 9.8 0.0 2.1 2 0 0 2 2 2 0 Phosphatidylinositol 3- and 4-kinase Pkinase PF00069.25 EFE37779.1 - 1.7e-06 27.6 0.0 2.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EFE37779.1 - 3.5e-05 23.2 0.0 5.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFE37779.1 - 7.9e-05 22.3 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFE37779.1 - 0.00097 19.1 2.7 0.0036 17.3 0.7 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE37779.1 - 0.0019 17.1 0.0 0.0024 16.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 EFE37779.1 - 0.0056 16.3 0.2 0.0093 15.6 0.2 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase WaaY PF06176.11 EFE37779.1 - 0.06 13.0 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) GDC-P PF02347.16 EFE37780.1 - 9.5e-173 575.0 0.0 1.6e-160 534.7 0.0 2.5 2 1 0 2 2 2 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 EFE37780.1 - 2.5e-07 30.3 0.1 6.1e-07 29.0 0.1 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EFE37780.1 - 0.0013 17.7 0.1 0.0042 16.1 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFE37780.1 - 0.0045 16.3 0.0 0.0077 15.6 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family TraF_2 PF13729.6 EFE37780.1 - 0.16 11.3 0.2 0.34 10.2 0.2 1.4 1 0 0 1 1 1 0 F plasmid transfer operon, TraF, protein Pyridoxal_deC PF00282.19 EFE37781.1 - 3e-104 348.7 0.0 3.5e-104 348.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EFE37781.1 - 0.00044 19.6 0.0 0.0011 18.3 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Abhydrolase_6 PF12697.7 EFE37782.1 - 4.1e-13 50.4 0.1 4.8e-13 50.2 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EFE37782.1 - 0.06 13.2 0.0 0.48 10.3 0.0 2.1 1 1 0 1 1 1 0 Serine hydrolase Abhydrolase_5 PF12695.7 EFE37782.1 - 0.18 11.6 0.2 0.69 9.7 0.2 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family MBOAT_2 PF13813.6 EFE37783.1 - 1.9e-22 79.3 2.2 2e-22 79.2 0.6 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Glyco_hydro_65N PF03636.15 EFE37784.1 - 1.9e-36 125.8 0.0 3.1e-36 125.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 EFE37784.1 - 1.2e-25 90.1 2.8 2.3e-20 72.8 0.7 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65C PF03633.15 EFE37784.1 - 7e-05 22.7 0.1 0.00021 21.1 0.1 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain Pkinase PF00069.25 EFE37785.1 - 1.9e-09 37.3 0.0 2.9e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37785.1 - 4.5e-08 32.7 0.0 1.6e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EFE37785.1 - 0.00013 21.4 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE37785.1 - 0.00022 21.2 0.1 0.00033 20.7 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE37785.1 - 0.0005 19.7 0.1 0.0018 17.9 0.0 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kinase-like PF14531.6 EFE37785.1 - 0.002 17.5 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EFE37785.1 - 0.0073 15.4 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.22 EFE37785.1 - 0.015 14.9 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Ank_2 PF12796.7 EFE37786.1 - 8e-14 52.0 0.0 0.00012 22.6 0.0 4.0 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFE37786.1 - 8.8e-13 48.2 1.5 3.8e-05 23.9 0.2 5.1 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE37786.1 - 2.5e-12 45.8 0.1 0.00084 19.6 0.0 5.8 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 EFE37786.1 - 2e-11 44.1 0.2 2e-05 25.0 0.1 4.8 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFE37786.1 - 1.4e-08 34.7 1.3 0.26 11.8 0.0 5.6 6 0 0 6 6 6 2 Ankyrin repeat DUF2202 PF09968.9 EFE37786.1 - 0.052 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) SMC_Nse1 PF07574.13 EFE37788.1 - 2.6e-52 177.6 0.2 1.8e-51 174.9 0.2 1.9 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex PaaX PF07848.12 EFE37788.1 - 0.0055 16.9 0.3 0.014 15.6 0.2 1.8 2 0 0 2 2 2 1 PaaX-like protein AbiEi_4 PF13338.6 EFE37788.1 - 0.019 15.1 1.8 0.036 14.2 0.5 2.1 1 1 1 2 2 2 0 Transcriptional regulator, AbiEi antitoxin DAO PF01266.24 EFE37789.1 - 3.9e-44 151.7 0.2 4.4e-44 151.5 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFE37789.1 - 0.0011 19.4 0.1 0.045 14.3 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFE37789.1 - 0.0058 16.6 0.1 0.014 15.4 0.1 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EFE37789.1 - 0.0099 16.1 0.1 0.023 14.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE37789.1 - 0.013 14.8 0.0 0.37 10.0 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DJ-1_PfpI PF01965.24 EFE37790.1 - 2.7e-20 72.8 0.0 4e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EFE37790.1 - 0.0013 18.6 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I RAI16-like PF10257.9 EFE37792.1 - 8.9e-77 258.4 0.0 1.5e-76 257.6 0.0 1.4 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein FAP PF07174.11 EFE37792.1 - 1.6 8.1 17.9 2.6 7.4 17.9 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Lipase_3 PF01764.25 EFE37793.1 - 2.3e-19 69.7 0.0 5.3e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) ILVD_EDD PF00920.21 EFE37794.1 - 3.5e-195 649.5 0.2 2.5e-194 646.7 0.2 1.9 1 1 0 1 1 1 1 Dehydratase family EIIBC-GUT_N PF03612.14 EFE37794.1 - 0.04 13.7 2.2 0.26 11.0 0.6 2.5 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus 5_nucleotid_C PF02872.18 EFE37794.1 - 0.055 13.7 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain Coilin_N PF15862.5 EFE37794.1 - 0.079 12.8 6.4 0.15 11.9 6.4 1.5 1 0 0 1 1 1 0 Coilin N-terminus DUF3824 PF12868.7 EFE37794.1 - 0.28 11.9 5.4 0.53 11.0 5.4 1.4 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) PPL5 PF18168.1 EFE37794.1 - 3.4 6.9 5.0 5.2 6.3 5.0 1.3 1 0 0 1 1 1 0 Prim-pol family 5 UPF0547 PF10571.9 EFE37796.1 - 0.049 13.7 0.3 0.1 12.7 0.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Pkinase PF00069.25 EFE37797.1 - 4.4e-45 154.1 0.0 6.5e-45 153.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37797.1 - 5.7e-29 101.2 0.0 8.1e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE37797.1 - 0.0048 15.7 0.0 0.0088 14.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFE37797.1 - 0.042 13.1 0.1 0.24 10.7 0.0 2.1 2 1 0 2 2 2 0 Kinase-like Tim17 PF02466.19 EFE37799.1 - 6.9e-28 97.2 3.2 9.3e-28 96.8 3.2 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2428 PF10350.9 EFE37801.1 - 7.1e-47 159.9 0.3 1.2e-46 159.1 0.3 1.3 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) LsmAD PF06741.13 EFE37802.1 - 0.13 12.8 1.2 0.17 12.4 1.2 1.2 1 0 0 1 1 1 0 LsmAD domain DUF4381 PF14316.6 EFE37803.1 - 0.011 16.0 3.6 0.037 14.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) EphA2_TM PF14575.6 EFE37803.1 - 0.6 11.0 2.8 0.48 11.3 0.3 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain GAPT PF11770.8 EFE37803.1 - 0.6 10.0 1.7 0.58 10.0 0.2 1.9 1 1 1 2 2 2 0 GRB2-binding adapter (GAPT) Ctr PF04145.15 EFE37803.1 - 1.4 9.5 6.5 8.5 7.0 6.5 2.0 1 1 0 1 1 1 0 Ctr copper transporter family DUF4554 PF15091.6 EFE37803.1 - 3.5 6.4 9.2 0.85 8.4 5.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4554) PX PF00787.24 EFE37804.1 - 1.3e-18 67.0 0.0 5.3e-18 65.0 0.0 2.0 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 EFE37804.1 - 6e-08 32.5 6.5 0.00075 19.1 1.0 2.1 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.18 EFE37804.1 - 0.34 10.5 3.3 4.4 6.9 0.7 2.3 2 0 0 2 2 2 0 BAR domain UCH PF00443.29 EFE37805.1 - 1e-69 234.9 0.0 1.8e-69 234.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EFE37805.1 - 4.9e-13 49.5 0.0 1.3e-12 48.1 0.0 1.8 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 EFE37805.1 - 1.1e-11 44.9 0.0 9.4e-05 22.2 0.0 3.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 EFE37805.1 - 0.0033 17.1 0.0 0.056 13.1 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal DUF2207 PF09972.9 EFE37806.1 - 0.0072 15.2 0.2 0.0092 14.8 0.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) GET2 PF08690.10 EFE37806.1 - 0.0086 15.8 0.3 0.0086 15.8 0.3 1.7 1 1 1 2 2 2 1 GET complex subunit GET2 SARAF PF06682.12 EFE37806.1 - 0.015 15.0 0.4 0.042 13.5 0.5 1.7 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF1676 PF07898.13 EFE37806.1 - 0.042 13.9 0.0 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) CD20 PF04103.15 EFE37806.1 - 0.06 13.4 0.1 0.11 12.6 0.1 1.4 1 1 0 1 1 1 0 CD20-like family U1snRNP70_N PF12220.8 EFE37806.1 - 0.063 13.9 2.3 0.14 12.8 2.3 1.6 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF5305 PF17231.2 EFE37806.1 - 0.099 12.0 0.1 0.099 12.0 0.1 2.1 3 0 0 3 3 3 0 Family of unknown function (DUF5305) Pox_EPC_I2-L1 PF12575.8 EFE37806.1 - 0.39 11.0 2.2 0.4 11.0 0.2 2.0 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 OATP PF03137.20 EFE37806.1 - 0.49 8.6 4.1 0.21 9.8 0.4 1.8 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family WTF PF03303.13 EFE37806.1 - 0.54 9.9 4.0 0.31 10.8 2.1 1.4 1 1 0 1 1 1 0 WTF protein Shisa PF13908.6 EFE37806.1 - 0.6 10.3 7.4 0.045 14.0 1.0 1.9 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator SPX PF03105.19 EFE37806.1 - 0.65 9.9 10.0 1.1 9.1 10.0 1.4 1 1 0 1 1 1 0 SPX domain Orf78 PF06024.12 EFE37806.1 - 0.74 10.1 10.6 19 5.6 10.6 2.2 1 1 0 1 1 1 0 Orf78 (ac78) Menin PF05053.13 EFE37806.1 - 0.9 7.8 5.5 1.3 7.2 5.5 1.2 1 0 0 1 1 1 0 Menin ExbD PF02472.16 EFE37806.1 - 1.8 8.8 5.1 1.1 9.5 0.1 2.4 1 1 1 2 2 2 0 Biopolymer transport protein ExbD/TolR TMEM132D_C PF15706.5 EFE37806.1 - 2.2 8.1 8.0 0.25 11.2 1.8 2.3 2 1 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Gtr1_RagA PF04670.12 EFE37808.1 - 3.3e-92 308.0 0.1 4e-92 307.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EFE37808.1 - 4.9e-08 33.2 0.0 8.7e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE37808.1 - 7.9e-08 31.9 0.0 1.2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFE37808.1 - 3.1e-07 30.1 0.0 4.7e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFE37808.1 - 3.7e-07 30.2 0.0 7.6e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFE37808.1 - 0.012 14.8 2.9 1.7 7.7 1.1 2.3 1 1 1 2 2 2 0 G-protein alpha subunit AAA_29 PF13555.6 EFE37808.1 - 0.012 15.4 0.6 0.042 13.6 0.3 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF815 PF05673.13 EFE37808.1 - 0.013 14.7 0.1 0.022 13.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 EFE37808.1 - 0.016 15.7 0.0 0.034 14.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EFE37808.1 - 0.074 12.9 0.4 0.42 10.5 0.1 2.3 3 1 1 4 4 4 0 RsgA GTPase AAA_7 PF12775.7 EFE37808.1 - 0.095 12.2 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1_Xtn PF16897.5 EFE37808.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AIG1 PF04548.16 EFE37808.1 - 0.34 10.2 1.0 0.5 9.7 0.4 1.8 2 1 0 2 2 2 0 AIG1 family AA_permease PF00324.21 EFE37809.1 - 1.6e-122 409.5 44.0 2.4e-122 409.0 44.0 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE37809.1 - 5.9e-32 111.0 44.1 7.8e-32 110.6 44.1 1.1 1 0 0 1 1 1 1 Amino acid permease RdRP PF05183.12 EFE37811.1 - 5e-126 421.7 0.0 6.9e-126 421.3 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase RAD51_interact PF15696.5 EFE37811.1 - 0.26 11.4 2.3 11 6.2 0.1 2.6 2 0 0 2 2 2 0 RAD51 interacting motif Opi1 PF08618.10 EFE37812.1 - 1.3e-42 146.5 22.2 3.9e-32 112.0 6.0 3.9 1 1 3 4 4 4 3 Transcription factor Opi1 bZIP_1 PF00170.21 EFE37813.1 - 3.9e-06 26.9 4.6 7.8e-06 25.9 4.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor LPP PF04728.13 EFE37813.1 - 0.16 12.4 0.1 0.35 11.3 0.1 1.5 1 0 0 1 1 1 0 Lipoprotein leucine-zipper NOA36 PF06524.12 EFE37816.1 - 0.00061 19.2 2.5 0.0009 18.6 2.5 1.1 1 0 0 1 1 1 1 NOA36 protein Cwf_Cwc_15 PF04889.12 EFE37816.1 - 0.00085 19.1 2.1 0.0012 18.6 2.1 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF4611 PF15387.6 EFE37816.1 - 0.054 13.7 3.4 0.11 12.8 3.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF2457 PF10446.9 EFE37816.1 - 5.7 6.0 12.8 9.5 5.2 12.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) AIM24 PF01987.17 EFE37817.1 - 3.2e-46 157.7 1.1 3.7e-46 157.5 1.1 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 eIF-5_eIF-2B PF01873.17 EFE37818.1 - 5.5e-24 84.3 0.0 1.1e-23 83.3 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Pol_alpha_B_N PF08418.10 EFE37818.1 - 0.017 15.1 7.2 0.023 14.7 7.2 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF2894 PF11445.8 EFE37818.1 - 0.62 10.5 6.2 13 6.1 6.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) Vfa1 PF08432.10 EFE37818.1 - 0.72 10.2 7.7 1 9.6 7.7 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 MIT PF04212.18 EFE37820.1 - 2.2e-10 40.4 1.1 5.3e-10 39.2 1.1 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain PC4 PF02229.16 EFE37821.1 - 7.2e-22 76.8 0.1 1.1e-21 76.2 0.1 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) Hydantoinase_B PF02538.14 EFE37822.1 - 1.8e-221 736.0 0.1 2.6e-221 735.5 0.1 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EFE37822.1 - 2.9e-102 341.8 0.6 5.7e-102 340.9 0.6 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EFE37822.1 - 5.9e-51 172.7 0.5 2.8e-49 167.2 0.0 2.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region CH PF00307.31 EFE37823.1 - 2.1e-73 243.5 0.0 5e-20 71.7 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EFE37823.1 - 1.4e-07 31.8 1.5 2.2e-06 28.0 0.6 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFE37823.1 - 0.0001 21.9 0.9 0.013 15.4 0.1 3.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EFE37823.1 - 0.00025 20.4 2.2 0.66 9.7 0.1 3.7 3 0 0 3 3 3 2 EF hand CAMSAP_CH PF11971.8 EFE37823.1 - 0.00048 19.9 0.0 0.64 9.9 0.0 3.8 4 0 0 4 4 4 1 CAMSAP CH domain EF-hand_5 PF13202.6 EFE37823.1 - 0.49 10.0 1.8 3.9 7.1 0.1 2.7 2 0 0 2 2 2 0 EF hand AhpC-TSA PF00578.21 EFE37824.1 - 2.4e-13 50.1 0.0 4e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFE37824.1 - 0.00065 19.4 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EFE37824.1 - 0.0039 17.3 0.1 0.0057 16.8 0.1 1.4 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme ADH_zinc_N_2 PF13602.6 EFE37824.1 - 0.1 13.7 0.0 0.14 13.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase SR-25 PF10500.9 EFE37824.1 - 0.22 11.1 10.7 0.29 10.7 10.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 EFE37824.1 - 0.22 11.7 9.7 0.34 11.1 9.7 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Peptidase_S49_N PF08496.10 EFE37824.1 - 0.76 9.8 6.8 1.2 9.2 6.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal APH PF01636.23 EFE37825.1 - 5.6e-14 52.6 0.0 1.1e-13 51.7 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFE37825.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase DUP PF00674.18 EFE37825.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 DUP family Peptidase_M16_M PF16187.5 EFE37826.1 - 2.3e-98 328.9 0.1 3.5e-98 328.3 0.1 1.3 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EFE37826.1 - 2.2e-36 125.6 0.5 2.5e-23 83.0 0.0 3.9 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFE37826.1 - 3.1e-33 114.9 1.2 6.9e-22 78.0 0.3 3.8 4 0 0 4 4 4 2 Insulinase (Peptidase family M16) DUF386 PF04074.12 EFE37827.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 YhcH/YjgK/YiaL DUF1258 PF06869.12 EFE37828.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) MFS_1 PF07690.16 EFE37829.1 - 6.1e-34 117.5 37.5 7.6e-34 117.2 37.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily ArenaCapSnatch PF17296.2 EFE37829.1 - 0.16 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Arenavirus cap snatching domain Sugar_tr PF00083.24 EFE37830.1 - 1.2e-124 416.7 23.8 1.6e-124 416.2 23.8 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE37830.1 - 7.1e-21 74.5 38.3 1.6e-15 56.9 17.4 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFE37830.1 - 0.013 13.9 7.2 0.026 13.0 1.5 2.1 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Coilin_N PF15862.5 EFE37830.1 - 2.8 7.7 6.3 40 4.0 5.3 2.5 3 0 0 3 3 3 0 Coilin N-terminus RNA_polI_A34 PF08208.11 EFE37830.1 - 4.7 7.2 14.0 9 6.3 14.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Arb2 PF09757.9 EFE37831.1 - 2.7e-82 275.8 12.1 1.1e-80 270.5 12.1 2.7 1 1 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 EFE37831.1 - 2.7e-37 128.9 0.0 4.2e-37 128.3 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Hist_deacetyl PF00850.19 EFE37832.1 - 2.7e-32 112.5 0.3 5.5e-31 108.2 0.0 2.1 2 0 0 2 2 2 2 Histone deacetylase domain Gp_dh_C PF02800.20 EFE37833.1 - 5.5e-71 237.3 0.0 8.6e-71 236.6 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EFE37833.1 - 8.8e-21 74.1 0.1 5.8e-20 71.5 0.1 2.1 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 EFE37833.1 - 0.089 12.8 0.0 0.49 10.4 0.0 2.0 2 0 0 2 2 2 0 Zinc-binding dehydrogenase F-box-like PF12937.7 EFE37834.1 - 7.4e-08 32.2 0.0 2.6e-07 30.4 0.0 2.0 1 0 0 1 1 1 1 F-box-like MBOAT PF03062.19 EFE37834.1 - 0.011 15.1 0.1 0.019 14.4 0.1 1.3 1 0 0 1 1 1 0 MBOAT, membrane-bound O-acyltransferase family F-box_4 PF15966.5 EFE37834.1 - 0.095 12.6 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 F-box Pho88 PF10032.9 EFE37835.1 - 3.4e-71 238.3 0.4 3.8e-71 238.1 0.4 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) DUF4512 PF14975.6 EFE37835.1 - 0.073 13.9 0.3 0.3 11.9 0.1 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4512) Histone PF00125.24 EFE37836.1 - 8.2e-16 58.6 0.0 1e-15 58.2 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EFE37836.1 - 5.7e-12 45.2 0.0 9.3e-12 44.5 0.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EFE37836.1 - 0.00026 21.2 0.0 0.00037 20.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HSF_DNA-bind PF00447.17 EFE37837.1 - 2.4e-29 101.8 0.3 5.3e-29 100.7 0.3 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.22 EFE37837.1 - 0.046 14.2 0.0 0.11 13.0 0.0 1.6 1 0 0 1 1 1 0 Ets-domain TMF_DNA_bd PF12329.8 EFE37837.1 - 0.12 12.4 1.7 0.35 10.9 0.1 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding R3H PF01424.22 EFE37839.1 - 9.1e-10 38.4 0.0 1.9e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 EFE37839.1 - 1.4e-05 24.8 0.1 2.9e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUIM_assoc PF16619.5 EFE37839.1 - 0.74 9.9 11.6 0.11 12.5 1.6 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Pro_isomerase PF00160.21 EFE37840.1 - 1.3e-37 129.5 0.0 2.7e-37 128.5 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ORC_WH_C PF18137.1 EFE37840.1 - 0.0016 18.5 1.6 0.0016 18.5 1.6 2.8 3 0 0 3 3 3 1 Origin recognition complex winged helix C-terminal His_Phos_2 PF00328.22 EFE37841.1 - 5.8e-10 39.1 0.0 2e-08 34.0 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Peptidase_M19 PF01244.21 EFE37842.1 - 7e-108 360.6 0.0 8.1e-108 360.4 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Rep_fac_C PF08542.11 EFE37843.1 - 9.8e-16 57.9 0.1 4.8e-15 55.7 0.0 2.3 3 0 0 3 3 2 1 Replication factor C C-terminal domain AAA PF00004.29 EFE37843.1 - 6.4e-15 55.7 0.4 2.3e-14 53.9 0.0 2.1 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EFE37843.1 - 6.9e-13 48.7 0.0 1.6e-12 47.6 0.0 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EFE37843.1 - 6.7e-09 35.9 0.0 1.1e-08 35.2 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EFE37843.1 - 3e-08 33.9 0.2 1.6e-07 31.6 0.0 2.3 3 0 0 3 3 2 1 AAA C-terminal domain AAA_22 PF13401.6 EFE37843.1 - 2.3e-06 27.9 0.1 8.9e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFE37843.1 - 2.3e-06 27.6 0.1 8.1e-06 25.9 0.0 2.0 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) DNA_pol3_delta PF06144.13 EFE37843.1 - 2.6e-06 27.3 0.3 4.9e-06 26.4 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EFE37843.1 - 3.3e-06 27.6 0.0 5.2e-05 23.7 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 EFE37843.1 - 7.1e-06 26.0 0.2 1.8e-05 24.7 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFE37843.1 - 1.1e-05 25.2 0.0 2.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EFE37843.1 - 7.5e-05 22.0 0.0 0.00014 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EFE37843.1 - 0.00014 21.7 0.0 0.00035 20.4 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 EFE37843.1 - 0.00026 21.4 0.0 0.00058 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EFE37843.1 - 0.00043 20.3 0.0 0.0033 17.4 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 EFE37843.1 - 0.00081 18.8 0.1 0.0026 17.1 0.0 1.7 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EFE37843.1 - 0.00092 19.1 0.0 0.0074 16.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 EFE37843.1 - 0.0011 18.3 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 EFE37843.1 - 0.0013 18.5 0.0 0.004 16.9 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.16 EFE37843.1 - 0.0031 17.0 0.0 0.58 9.6 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_24 PF13479.6 EFE37843.1 - 0.0039 17.0 0.0 0.0086 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFE37843.1 - 0.0092 16.5 0.0 0.019 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFE37843.1 - 0.018 15.3 0.0 0.044 14.0 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 EFE37843.1 - 0.028 14.0 0.0 0.054 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EFE37843.1 - 0.032 13.6 0.0 0.21 11.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_25 PF13481.6 EFE37843.1 - 0.05 13.2 0.0 0.14 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFE37843.1 - 0.06 13.7 0.0 0.2 12.0 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Sigma54_activat PF00158.26 EFE37843.1 - 0.086 12.5 0.0 3.2 7.4 0.0 2.5 3 0 0 3 3 2 0 Sigma-54 interaction domain MiaE PF06175.11 EFE37843.1 - 0.12 12.0 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) ATPase_2 PF01637.18 EFE37843.1 - 0.18 11.7 0.0 0.3 11.0 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea P21-Arc PF04062.14 EFE37844.1 - 1.4e-48 165.2 0.0 1.7e-48 164.9 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit NAD_binding_10 PF13460.6 EFE37845.1 - 2.5e-16 60.1 0.1 3.8e-16 59.5 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFE37845.1 - 1.4e-15 57.5 0.1 3.1e-15 56.4 0.1 1.7 2 1 0 2 2 2 1 NmrA-like family DapB_N PF01113.20 EFE37845.1 - 1.3e-07 31.8 0.2 2.5e-07 30.9 0.2 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 EFE37845.1 - 1.4e-06 28.0 0.2 2.1e-06 27.4 0.2 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EFE37845.1 - 3.7e-06 27.4 0.1 6.4e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EFE37845.1 - 0.00013 21.1 0.1 0.00019 20.5 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFE37845.1 - 0.0035 16.5 0.0 0.0053 15.9 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein TrkA_N PF02254.18 EFE37845.1 - 0.0039 17.4 0.7 0.0085 16.3 0.7 1.6 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.15 EFE37845.1 - 0.0049 16.0 0.1 0.007 15.5 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EFE37845.1 - 0.0061 16.5 0.1 0.01 15.7 0.1 1.3 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 EFE37845.1 - 0.018 14.2 0.2 0.026 13.6 0.2 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain GFO_IDH_MocA PF01408.22 EFE37845.1 - 0.03 15.2 0.3 0.062 14.1 0.3 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Ldh_1_N PF00056.23 EFE37845.1 - 0.036 14.2 0.4 0.066 13.3 0.4 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain KcnmB2_inactiv PF09303.10 EFE37845.1 - 0.11 12.3 0.0 0.32 10.8 0.0 1.8 1 0 0 1 1 1 0 KCNMB2, ball and chain domain Pkinase PF00069.25 EFE37846.1 - 5.7e-15 55.4 0.0 4.8e-10 39.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37846.1 - 1.4e-06 27.8 0.0 0.011 15.0 0.0 2.3 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFE37846.1 - 0.00075 19.5 0.1 0.03 14.2 0.1 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFE37846.1 - 0.16 11.2 0.1 12 5.1 0.1 2.1 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 EFE37846.1 - 0.44 9.3 1.4 2.5 6.8 0.2 1.9 1 1 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EFE37847.1 - 7.7e-12 45.7 0.0 3.1e-11 43.6 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFE37847.1 - 0.00061 19.2 0.0 0.58 9.5 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M35 PF02102.15 EFE37848.1 - 1.7e-46 158.7 8.0 2e-46 158.6 8.0 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Peptidase_M35 PF02102.15 EFE37849.1 - 2.7e-41 141.7 4.5 3e-41 141.5 4.5 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EFE37849.1 - 6.3e-29 101.4 0.7 7.1e-29 101.2 0.7 1.0 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase MINDY_DUB PF04424.13 EFE37850.1 - 1.3e-18 67.1 0.0 2.2e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 MINDY deubiquitinase Gcd10p PF04189.13 EFE37851.1 - 1.3e-117 392.2 0.0 1.6e-117 391.9 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family CorA PF01544.18 EFE37854.1 - 0.00027 20.4 0.5 0.00051 19.5 0.5 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein NmrA PF05368.13 EFE37855.1 - 5.5e-46 157.0 2.2 1.4e-28 100.1 1.3 2.1 1 1 1 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 EFE37855.1 - 1.4e-14 54.4 0.2 1.2e-13 51.4 0.6 1.9 1 1 1 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFE37855.1 - 0.0044 16.1 0.0 0.006 15.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EFE37855.1 - 0.009 16.3 0.1 0.014 15.7 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AIG1 PF04548.16 EFE37855.1 - 0.015 14.6 0.1 0.028 13.7 0.1 1.4 1 0 0 1 1 1 0 AIG1 family Guanylate_kin PF00625.21 EFE37855.1 - 0.17 11.5 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Guanylate kinase Myb_DNA-binding PF00249.31 EFE37856.1 - 3.7e-17 62.2 0.0 5.6e-09 36.1 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFE37856.1 - 1.9e-06 28.0 0.0 0.029 14.6 0.1 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFE37856.1 - 0.00019 21.3 0.0 0.00019 21.3 0.0 3.8 4 0 0 4 4 4 1 Myb DNA-binding like Abhydrolase_1 PF00561.20 EFE37859.1 - 0.0016 18.2 0.3 0.0047 16.6 0.2 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EFE37859.1 - 0.0058 16.3 0.0 0.015 14.9 0.0 1.7 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EFE37859.1 - 0.015 14.8 0.0 0.015 14.8 0.0 2.2 3 0 0 3 3 3 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFE37859.1 - 0.015 14.5 0.0 0.11 11.7 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 TMF_TATA_bd PF12325.8 EFE37860.1 - 0.00012 22.3 4.1 0.00012 22.3 4.1 3.5 2 2 1 3 3 3 1 TATA element modulatory factor 1 TATA binding TolA_bind_tri PF16331.5 EFE37860.1 - 0.00075 19.5 2.7 0.00075 19.5 2.7 2.6 3 0 0 3 3 3 1 TolA binding protein trimerisation DUF773 PF05600.12 EFE37860.1 - 0.0047 15.7 2.4 0.009 14.8 2.4 1.5 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 ABC_tran_CTD PF16326.5 EFE37860.1 - 0.017 15.4 1.0 0.017 15.4 1.0 3.9 3 1 1 4 4 4 0 ABC transporter C-terminal domain CorA PF01544.18 EFE37860.1 - 0.024 14.0 0.5 0.024 14.0 0.5 1.7 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DNA_repr_REX1B PF14966.6 EFE37860.1 - 0.041 14.5 1.1 0.14 12.9 1.1 1.9 1 0 0 1 1 1 0 DNA repair REX1-B DUF465 PF04325.13 EFE37860.1 - 0.088 12.9 3.1 1.9 8.6 1.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF465) FlgN PF05130.12 EFE37860.1 - 0.088 13.3 9.9 1.7 9.2 2.6 2.6 2 1 0 2 2 2 0 FlgN protein DUF1090 PF06476.12 EFE37860.1 - 0.13 12.4 2.2 0.32 11.1 2.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) DUF2730 PF10805.8 EFE37860.1 - 0.14 12.3 4.1 0.1 12.7 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) COG2 PF06148.11 EFE37860.1 - 0.18 11.9 6.8 0.074 13.1 1.2 2.6 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Med4 PF10018.9 EFE37860.1 - 0.18 11.5 5.4 0.37 10.4 1.6 2.7 2 1 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF1515 PF07439.11 EFE37860.1 - 0.3 11.1 5.0 0.23 11.5 1.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Maf1 PF09174.10 EFE37860.1 - 0.3 11.2 2.0 2.1 8.5 2.0 2.2 1 1 0 1 1 1 0 Maf1 regulator APG6_N PF17675.1 EFE37860.1 - 0.55 10.8 21.5 0.46 11.0 5.8 3.4 1 1 2 3 3 3 0 Apg6 coiled-coil region WDCP PF15390.6 EFE37860.1 - 0.59 8.4 5.7 0.84 7.9 5.5 1.4 1 1 0 1 1 1 0 WD repeat and coiled-coil-containing protein family ATG16 PF08614.11 EFE37860.1 - 1 9.5 12.6 0.033 14.4 3.9 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Prominin PF05478.11 EFE37860.1 - 1.2 7.0 5.6 0.27 9.1 2.5 1.4 2 0 0 2 2 2 0 Prominin DivIC PF04977.15 EFE37860.1 - 1.4 8.8 3.8 1.4 8.8 1.5 2.3 2 0 0 2 2 2 0 Septum formation initiator CENP-F_leu_zip PF10473.9 EFE37860.1 - 1.6 8.7 19.8 0.035 14.1 6.0 3.0 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.22 EFE37860.1 - 1.8 8.8 9.7 1.4 9.2 3.4 2.8 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain SlyX PF04102.12 EFE37860.1 - 1.9 9.2 6.7 0.55 10.9 1.0 3.0 2 1 0 2 2 2 0 SlyX Spc7 PF08317.11 EFE37860.1 - 1.9 7.3 16.5 0.17 10.7 5.6 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Allexi_40kDa PF05549.11 EFE37860.1 - 2.1 7.8 6.7 0.72 9.3 1.6 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein DUF1664 PF07889.12 EFE37860.1 - 2.9 7.9 6.9 1.4 9.0 1.6 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) CCDC-167 PF15188.6 EFE37860.1 - 3.2 8.2 21.2 0.29 11.5 0.6 3.9 3 1 1 4 4 4 0 Coiled-coil domain-containing protein 167 Phage_GP20 PF06810.11 EFE37860.1 - 3.9 7.3 8.4 4.9 6.9 0.3 2.7 2 1 1 3 3 3 0 Phage minor structural protein GP20 Fib_alpha PF08702.10 EFE37860.1 - 4.4 7.5 7.6 0.66 10.2 1.0 2.6 2 2 0 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.11 EFE37860.1 - 4.8 7.8 9.2 6.9 7.3 1.1 3.1 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF2959 PF11172.8 EFE37860.1 - 7.3 6.7 10.5 9.2 6.4 3.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2959) FlaC_arch PF05377.11 EFE37860.1 - 9.8 6.7 7.0 18 5.8 3.4 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) RPN2_C PF18004.1 EFE37861.1 - 2e-57 193.6 7.8 2e-57 193.6 7.8 2.3 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EFE37861.1 - 1.8e-32 110.1 24.9 7.7e-10 38.7 0.0 8.8 8 0 0 8 8 8 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EFE37861.1 - 4e-22 78.4 0.5 6.7e-16 58.5 0.0 4.0 3 1 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 EFE37861.1 - 8.9e-09 35.7 0.1 0.019 15.5 0.0 4.0 3 0 0 3 3 3 2 HEAT-like repeat HEAT PF02985.22 EFE37861.1 - 4.1e-06 26.6 0.1 1.8 9.0 0.0 4.8 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 EFE37861.1 - 0.0025 17.9 0.0 0.18 11.9 0.0 2.8 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EFE37861.1 - 0.0078 16.8 2.3 1.1 10.1 0.0 4.0 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat GCIP PF13324.6 EFE37861.1 - 0.081 12.5 5.2 0.17 11.5 5.2 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF913 PF06025.12 EFE37861.1 - 5.1 6.0 8.8 4.5 6.1 1.1 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) RRN3 PF05327.11 EFE37861.1 - 8 4.9 7.3 14 4.1 7.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Acyl-CoA_dh_1 PF00441.24 EFE37862.1 - 2e-41 141.7 0.3 2.9e-41 141.2 0.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFE37862.1 - 2.5e-21 75.7 0.1 4.1e-21 75.0 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EFE37862.1 - 5.5e-20 72.1 0.0 1.1e-19 71.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Cyt-b5 PF00173.28 EFE37862.1 - 6.3e-15 55.1 0.3 1.2e-14 54.1 0.3 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_2 PF08028.11 EFE37862.1 - 3.6e-09 37.0 0.0 5.9e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain C6 PF01681.17 EFE37862.1 - 0.2 12.2 0.1 0.76 10.3 0.0 2.0 2 0 0 2 2 2 0 C6 domain DEC-1_N PF04625.13 EFE37862.1 - 4.8 6.1 7.8 1.3 7.9 4.9 1.5 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region Spt5-NGN PF03439.13 EFE37863.1 - 5.2e-23 80.8 0.0 9.8e-23 79.9 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section CTD PF12815.7 EFE37863.1 - 1.2e-19 70.6 16.5 1.2e-19 70.6 16.5 3.8 1 1 2 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5_N PF11942.8 EFE37863.1 - 2e-17 64.0 10.7 2e-17 64.0 10.7 3.9 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 EFE37863.1 - 1.1e-10 41.1 14.5 0.0034 17.3 1.6 5.3 5 0 0 5 5 5 3 KOW motif DUF3912 PF13051.6 EFE37863.1 - 0.00048 20.3 7.5 0.013 15.8 0.0 3.5 4 0 0 4 4 4 2 Protein of unknown function (DUF3912) DUF1506 PF07405.11 EFE37863.1 - 0.22 11.7 0.2 0.88 9.8 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1506) CS PF04969.16 EFE37864.1 - 4.4e-16 59.7 0.1 9.4e-16 58.6 0.1 1.6 1 0 0 1 1 1 1 CS domain PIH1_CS PF18201.1 EFE37864.1 - 0.075 13.4 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 PIH1 CS-like domain Anoctamin PF04547.12 EFE37865.1 - 2e-108 363.1 11.3 2.6e-108 362.7 11.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Pex2_Pex12 PF04757.14 EFE37865.1 - 0.03 13.9 2.0 0.037 13.6 0.0 2.2 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region APH PF01636.23 EFE37866.1 - 0.00023 21.2 0.1 0.00023 21.2 0.1 3.1 3 2 1 4 4 4 1 Phosphotransferase enzyme family HSDR_N_2 PF13588.6 EFE37866.1 - 0.00041 20.3 0.0 1 9.4 0.0 2.7 3 0 0 3 3 3 2 Type I restriction enzyme R protein N terminus (HSDR_N) Choline_kinase PF01633.20 EFE37866.1 - 0.0021 17.7 0.0 0.0046 16.6 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EFE37866.1 - 0.0079 15.6 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EFE37866.1 - 0.028 13.8 0.2 0.028 13.8 0.2 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family K_channel_TID PF07941.11 EFE37866.1 - 0.15 12.6 7.6 0.065 13.7 2.0 2.9 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain Atg14 PF10186.9 EFE37866.1 - 1.1 8.3 5.0 1.8 7.6 5.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 bZIP_1 PF00170.21 EFE37867.1 - 1.6e-07 31.3 8.9 1.2e-06 28.5 8.9 2.1 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EFE37867.1 - 0.49 10.5 11.6 5.4 7.2 10.1 2.9 2 1 0 2 2 2 0 Basic region leucine zipper Actin PF00022.19 EFE37868.1 - 1.3e-53 182.2 0.0 1.2e-50 172.4 0.0 2.5 1 1 0 1 1 1 1 Actin YL1_C PF08265.11 EFE37869.1 - 5.6e-17 61.2 0.3 8.9e-17 60.5 0.3 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Gag_p12 PF01141.18 EFE37869.1 - 0.38 11.1 3.1 0.26 11.6 0.8 1.9 2 0 0 2 2 2 0 Gag polyprotein, inner coat protein p12 Sec63 PF02889.16 EFE37872.1 - 8.2e-125 415.1 0.0 9.4e-77 257.6 0.1 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EFE37872.1 - 1.8e-53 180.9 1.2 3.1e-26 92.2 1.5 2.8 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EFE37872.1 - 8.2e-23 81.3 0.0 5.2e-11 42.8 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFE37872.1 - 4.2e-15 56.0 0.1 4.2e-07 30.3 0.0 4.3 4 2 0 4 4 4 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 EFE37872.1 - 1.6e-07 31.2 0.3 0.0012 18.6 0.5 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFE37872.1 - 3.8e-07 30.5 2.6 0.0048 17.2 0.0 3.6 3 1 0 3 3 2 2 AAA domain AAA_19 PF13245.6 EFE37872.1 - 2.8e-05 24.5 1.6 0.0019 18.5 1.1 2.5 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFE37872.1 - 0.0072 15.4 0.0 2.5 7.1 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein PhoH PF02562.16 EFE37872.1 - 0.011 15.2 0.0 0.7 9.3 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein Helicase_PWI PF18149.1 EFE37872.1 - 0.016 15.4 0.0 0.038 14.1 0.0 1.6 1 0 0 1 1 1 0 N-terminal helicase PWI domain TniB PF05621.11 EFE37872.1 - 0.028 13.8 0.5 20 4.5 0.1 3.7 4 0 0 4 4 4 0 Bacterial TniB protein AAA_7 PF12775.7 EFE37872.1 - 0.038 13.5 0.1 3.2 7.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EFE37872.1 - 0.063 13.0 0.1 3.9 7.2 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein DEK_C PF08766.11 EFE37872.1 - 0.076 12.9 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 DEK C terminal domain FtsK_SpoIIIE PF01580.18 EFE37872.1 - 0.22 10.9 0.8 0.75 9.1 0.8 1.9 1 1 0 1 1 1 0 FtsK/SpoIIIE family Synaptobrevin PF00957.21 EFE37873.1 - 5.8e-14 51.6 0.2 8.6e-14 51.1 0.2 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFE37873.1 - 9.5e-12 44.8 0.0 1.7e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Pkinase PF00069.25 EFE37876.1 - 1.9e-23 83.2 0.0 2.9e-22 79.3 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37876.1 - 9.8e-06 25.0 0.0 0.0052 16.1 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase MFS_1 PF07690.16 EFE37877.1 - 8.3e-12 44.7 14.8 8.3e-12 44.7 14.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFE37877.1 - 9.3e-08 31.0 5.3 1.6e-07 30.3 5.3 1.5 1 0 0 1 1 1 1 MFS/sugar transport protein DUF5337 PF17272.2 EFE37877.1 - 0.05 13.4 0.7 0.2 11.5 0.7 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5337) Ras PF00071.22 EFE37879.1 - 1.9e-34 118.6 0.0 1.2e-32 112.7 0.0 2.3 2 1 0 2 2 2 1 Ras family Roc PF08477.13 EFE37879.1 - 6e-28 97.5 0.0 1e-27 96.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE37879.1 - 4.4e-10 39.3 0.0 6.5e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFE37879.1 - 0.00054 20.0 0.0 0.0009 19.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFE37879.1 - 0.0023 18.3 0.1 0.0045 17.4 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFE37879.1 - 0.024 14.9 0.1 0.064 13.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 EFE37879.1 - 0.03 13.7 0.0 0.046 13.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EFE37879.1 - 0.069 12.9 0.0 0.79 9.5 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EFE37879.1 - 0.078 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 EFE37879.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 EFE37879.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 EFE37879.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain FMN_dh PF01070.18 EFE37880.1 - 1.8e-121 405.5 0.2 2e-121 405.3 0.2 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 EFE37880.1 - 6.1e-06 25.8 0.6 6.7e-05 22.4 0.1 2.0 2 0 0 2 2 2 1 Nitronate monooxygenase Glu_synthase PF01645.17 EFE37880.1 - 9.5e-06 25.0 0.1 1.5e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EFE37880.1 - 0.00059 18.9 2.8 0.002 17.2 0.2 2.7 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EFE37880.1 - 0.028 13.9 0.0 2.1 7.8 0.0 2.2 2 0 0 2 2 2 0 Histidine biosynthesis protein T6SS_VasJ PF16989.5 EFE37880.1 - 0.086 12.3 0.1 0.69 9.3 0.0 2.0 2 0 0 2 2 2 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ Pkinase PF00069.25 EFE37881.1 - 4.8e-40 137.6 0.0 1.3e-22 80.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37881.1 - 1.1e-12 47.8 0.0 3.8e-09 36.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE37881.1 - 0.17 10.6 1.5 0.18 10.5 0.3 1.6 1 1 1 2 2 2 0 Fungal protein kinase Bud13 PF09736.9 EFE37882.1 - 2.1e-49 167.6 2.1 2.1e-49 167.6 2.1 3.0 2 1 1 3 3 3 1 Pre-mRNA-splicing factor of RES complex SPATIAL PF15256.6 EFE37882.1 - 6 7.1 9.7 0.58 10.5 4.5 1.8 2 0 0 2 2 2 0 SPATIAL DUF812 PF05667.11 EFE37883.1 - 0.0068 15.4 0.2 0.0073 15.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Macoilin PF09726.9 EFE37883.1 - 0.023 13.3 0.7 0.029 12.9 0.7 1.1 1 0 0 1 1 1 0 Macoilin family DUF1192 PF06698.11 EFE37883.1 - 0.072 13.1 1.1 0.18 11.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Bap31_Bap29_C PF18035.1 EFE37883.1 - 0.082 12.9 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Fungal_trans_2 PF11951.8 EFE37886.1 - 1.9e-96 323.2 1.2 2.3e-96 322.9 1.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Brr6_like_C_C PF10104.9 EFE37887.1 - 1.6e-47 160.6 0.7 2.2e-47 160.2 0.7 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain AA_permease PF00324.21 EFE37888.1 - 6e-40 137.2 10.6 7.3e-40 136.9 10.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE37888.1 - 3.3e-05 22.9 18.3 0.00022 20.2 18.1 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE37889.1 - 1e-16 60.6 9.5 1.2e-16 60.4 9.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE37889.1 - 0.072 11.9 11.7 0.087 11.6 11.7 1.0 1 0 0 1 1 1 0 Amino acid permease AA_permease_2 PF13520.6 EFE37890.1 - 1.4e-32 113.1 28.3 4.7e-31 108.1 24.1 2.7 1 1 1 2 2 2 1 Amino acid permease ADH_zinc_N_2 PF13602.6 EFE37891.1 - 0.0085 17.2 0.0 0.011 16.8 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFE37891.1 - 0.034 14.1 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 Zinc-binding dehydrogenase GAD PF02938.14 EFE37891.1 - 0.04 14.2 0.0 0.047 13.9 0.0 1.2 1 0 0 1 1 1 0 GAD domain Interferon PF00143.19 EFE37891.1 - 0.055 13.7 0.0 0.071 13.3 0.0 1.1 1 0 0 1 1 1 0 Interferon alpha/beta domain ADH_zinc_N PF00107.26 EFE37892.1 - 3.8e-13 49.5 0.0 5.9e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE37892.1 - 0.00013 21.8 0.0 0.0003 20.6 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EFE37892.1 - 0.013 14.8 1.2 0.021 14.1 1.2 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 EFE37892.1 - 0.026 14.0 0.8 0.071 12.6 0.6 1.9 2 0 0 2 2 2 0 short chain dehydrogenase APH PF01636.23 EFE37893.1 - 5.6e-11 42.8 0.0 3.6e-05 23.8 0.0 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family GYF PF02213.16 EFE37895.1 - 3.1e-16 58.8 2.3 4e-16 58.4 0.4 2.3 2 0 0 2 2 2 1 GYF domain B12D PF06522.11 EFE37895.1 - 0.035 13.9 0.8 0.14 12.0 0.0 2.4 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit GYF_2 PF14237.6 EFE37895.1 - 0.16 11.8 0.3 0.44 10.4 0.3 1.8 1 0 0 1 1 1 0 GYF domain 2 Homeodomain PF00046.29 EFE37895.1 - 0.42 10.5 3.7 1.4 8.8 3.7 1.9 1 0 0 1 1 1 0 Homeodomain MCLC PF05934.11 EFE37895.1 - 1.9 7.1 4.0 4 6.1 4.0 1.4 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Aminotran_5 PF00266.19 EFE37896.1 - 6.7e-20 71.4 0.0 9.8e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFE37896.1 - 0.00018 20.8 0.0 0.00025 20.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFE37896.1 - 0.0029 16.2 0.0 0.0046 15.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme zf-RING_2 PF13639.6 EFE37897.1 - 4.3e-13 49.4 9.3 6.6e-13 48.8 9.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFE37897.1 - 9.6e-11 41.2 4.0 1.7e-10 40.5 4.0 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFE37897.1 - 5e-09 35.9 8.9 7.6e-09 35.3 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE37897.1 - 9.8e-08 31.7 4.5 1.4e-07 31.2 4.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFE37897.1 - 1.2e-07 31.9 7.7 2.5e-07 30.9 7.7 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFE37897.1 - 4.8e-07 29.6 6.0 7.6e-07 29.0 6.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFE37897.1 - 6.4e-07 29.1 8.5 1e-06 28.5 8.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE37897.1 - 1.2e-05 25.2 3.0 2.9e-05 24.0 3.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFE37897.1 - 0.00028 20.7 5.2 0.00051 19.8 5.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFE37897.1 - 0.00035 20.5 2.8 0.00068 19.6 2.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EFE37897.1 - 0.003 17.1 6.7 0.0048 16.5 6.7 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EFE37897.1 - 0.12 12.2 4.8 0.21 11.4 4.8 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Baculo_RING PF05883.11 EFE37897.1 - 0.16 11.9 0.4 0.3 11.1 0.4 1.3 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-C3H2C3 PF17122.5 EFE37897.1 - 0.17 11.9 6.4 0.29 11.2 6.4 1.4 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.29 EFE37897.1 - 0.32 10.9 7.5 0.57 10.1 7.5 1.4 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.7 EFE37897.1 - 0.33 11.1 10.1 0.65 10.2 10.1 1.5 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 EFE37897.1 - 0.58 10.4 7.3 2.8 8.2 7.3 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 EFE37897.1 - 1.2 9.4 6.2 2.5 8.3 6.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Spt20 PF12090.8 EFE37897.1 - 2.8 7.5 18.0 0.027 14.1 8.1 2.1 2 0 0 2 2 2 0 Spt20 family Fis1_TPR_C PF14853.6 EFE37898.1 - 6.5e-26 90.2 0.4 1e-25 89.5 0.4 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EFE37898.1 - 2e-12 46.6 0.3 1.9e-07 30.6 0.0 2.3 2 0 0 2 2 2 2 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 EFE37898.1 - 0.0013 18.7 1.6 0.0026 17.7 1.6 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFE37898.1 - 0.12 12.2 2.4 0.26 11.2 2.4 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Spc24 PF08286.11 EFE37899.1 - 3.3e-39 133.3 3.9 9.2e-38 128.7 0.2 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 MAP65_ASE1 PF03999.12 EFE37899.1 - 0.0042 15.9 3.7 0.0044 15.8 3.7 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) APG6_N PF17675.1 EFE37899.1 - 0.0085 16.6 12.0 0.012 16.1 12.0 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region FlxA PF14282.6 EFE37899.1 - 0.017 15.1 2.4 2.2 8.3 0.1 2.2 2 0 0 2 2 2 0 FlxA-like protein WXG100 PF06013.12 EFE37899.1 - 0.021 15.0 3.1 0.18 12.0 0.2 2.6 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Spc7 PF08317.11 EFE37899.1 - 0.035 13.0 8.7 0.047 12.6 8.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FlaC_arch PF05377.11 EFE37899.1 - 0.042 14.2 4.2 0.79 10.2 0.2 2.5 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) CLZ PF16526.5 EFE37899.1 - 0.067 13.6 9.8 0.2 12.0 1.5 2.4 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4472 PF14739.6 EFE37899.1 - 0.069 13.9 1.8 0.069 13.9 1.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) DUF3584 PF12128.8 EFE37899.1 - 0.078 10.5 8.8 0.098 10.2 8.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Syntaxin PF00804.25 EFE37899.1 - 0.086 12.5 4.9 0.15 11.8 4.7 1.5 1 1 0 1 1 1 0 Syntaxin DUF4337 PF14235.6 EFE37899.1 - 0.097 12.8 4.1 0.2 11.8 3.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF4795 PF16043.5 EFE37899.1 - 0.1 12.2 5.3 0.67 9.5 5.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF5344 PF17279.2 EFE37899.1 - 0.11 13.1 2.4 4.1 8.0 0.2 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5344) V_ATPase_I PF01496.19 EFE37899.1 - 0.11 10.4 1.5 0.11 10.3 1.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Prefoldin_2 PF01920.20 EFE37899.1 - 0.12 12.3 7.2 0.66 10.0 1.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit FapA PF03961.13 EFE37899.1 - 0.19 10.3 2.1 0.22 10.1 2.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A EAP30 PF04157.16 EFE37899.1 - 0.31 10.3 6.3 21 4.3 6.3 2.1 1 1 0 1 1 1 0 EAP30/Vps36 family BLOC1_2 PF10046.9 EFE37899.1 - 0.4 11.0 3.8 0.95 9.8 3.3 1.9 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DHR10 PF18595.1 EFE37899.1 - 0.44 10.6 14.8 2 8.5 14.8 1.9 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain YlqD PF11068.8 EFE37899.1 - 0.49 10.8 4.8 0.76 10.1 4.8 1.3 1 0 0 1 1 1 0 YlqD protein Ribosomal_L29 PF00831.23 EFE37899.1 - 0.65 10.0 7.7 1.5 8.9 0.8 2.6 2 0 0 2 2 2 0 Ribosomal L29 protein Swi5 PF07061.11 EFE37899.1 - 0.82 9.8 4.4 9.4 6.4 0.4 2.4 2 0 0 2 2 2 0 Swi5 SlyX PF04102.12 EFE37899.1 - 1.1 9.9 7.9 1.8 9.2 1.1 2.5 2 1 0 2 2 2 0 SlyX Phage_GPO PF05929.11 EFE37899.1 - 1.1 8.8 6.4 4 7.0 6.4 1.8 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase YabA PF06156.13 EFE37899.1 - 1.3 9.7 4.7 22 5.8 0.3 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Csm1_N PF18504.1 EFE37899.1 - 1.8 8.9 7.3 6.8 7.1 0.9 2.3 2 0 0 2 2 2 0 Csm1 N-terminal domain Viral_P18 PF04521.13 EFE37899.1 - 2.9 7.7 6.3 6.2 6.6 1.1 2.4 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein DUF1690 PF07956.11 EFE37899.1 - 4.5 7.7 10.3 16 5.9 10.3 1.8 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF4140 PF13600.6 EFE37899.1 - 5.3 7.5 9.4 7.9 7.0 2.1 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DASH_Hsk3 PF08227.11 EFE37899.1 - 6.1 7.3 9.6 3 8.3 0.8 2.7 2 1 1 3 3 3 0 DASH complex subunit Hsk3 like DUF3431 PF11913.8 EFE37900.1 - 2.7e-61 207.1 0.0 3.9e-60 203.3 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) MbtH PF03621.13 EFE37900.1 - 0.1 12.1 0.1 0.26 10.8 0.1 1.6 1 0 0 1 1 1 0 MbtH-like protein PsbT PF01405.17 EFE37900.1 - 3.1 7.7 5.6 7.1 6.5 5.6 1.5 1 0 0 1 1 1 0 Photosystem II reaction centre T protein Med21 PF11221.8 EFE37901.1 - 7.9e-52 175.3 22.3 2.2e-49 167.4 22.3 2.1 1 1 0 1 1 1 1 Subunit 21 of Mediator complex DUF2201_N PF13203.6 EFE37901.1 - 0.0036 17.0 0.0 0.011 15.3 0.0 1.6 1 1 0 2 2 2 1 Putative metallopeptidase domain TFIIA PF03153.13 EFE37901.1 - 0.0047 17.0 11.7 0.005 16.9 11.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spore_III_AB PF09548.10 EFE37901.1 - 0.036 14.2 0.4 0.075 13.1 0.4 1.6 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF4194 PF13835.6 EFE37901.1 - 0.11 12.2 2.9 0.18 11.6 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4194) DUF4175 PF13779.6 EFE37901.1 - 0.13 10.2 19.5 0.18 9.7 19.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Atypical_Card PF18461.1 EFE37901.1 - 0.15 12.3 0.0 0.38 11.0 0.0 1.7 1 0 0 1 1 1 0 Atypical caspase recruitment domain Spt20 PF12090.8 EFE37901.1 - 0.31 10.6 15.0 0.43 10.2 15.0 1.2 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 EFE37901.1 - 1 9.3 6.9 1.2 9.0 6.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ndc1_Nup PF09531.10 EFE37901.1 - 2.9 6.5 4.9 3.2 6.3 4.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NINJA_B PF16136.5 EFE37901.1 - 8.3 6.8 14.0 5.6 7.4 3.4 2.3 2 0 0 2 2 2 0 Putative nuclear localisation signal SNF2_N PF00176.23 EFE37902.1 - 7.1e-65 219.0 0.0 1e-64 218.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE37902.1 - 6.5e-12 45.8 0.0 3.6e-11 43.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE37902.1 - 6.6e-06 26.0 0.0 1.8e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFE37902.1 - 0.00024 21.2 0.0 0.00056 20.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Prok-RING_4 PF14447.6 EFE37902.1 - 0.018 14.9 1.8 0.046 13.6 1.8 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF896 PF05979.12 EFE37902.1 - 2.1 8.3 6.9 40 4.2 0.0 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) PI3_PI4_kinase PF00454.27 EFE37903.1 - 4.9e-45 154.3 0.0 8.2e-45 153.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase EF-hand_1 PF00036.32 EFE37903.1 - 0.17 11.5 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 EF hand Nas2_N PF18265.1 EFE37904.1 - 1.3e-13 50.7 0.1 1.8e-13 50.2 0.1 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 EFE37905.1 - 6.8e-07 29.0 0.0 1.1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EFE37905.1 - 3.6e-06 27.2 0.1 5e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EFE37905.1 - 1.6e-05 25.1 0.1 2.1e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 PDZ domain Ras PF00071.22 EFE37906.1 - 2e-49 167.3 0.0 2.5e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE37906.1 - 2.4e-29 102.0 0.0 6.1e-29 100.7 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE37906.1 - 5.8e-11 42.2 0.0 8.5e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 EFE37906.1 - 0.00026 21.3 0.1 0.0015 18.9 0.1 2.0 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 EFE37906.1 - 0.00095 19.2 0.0 0.002 18.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFE37906.1 - 0.0012 18.3 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFE37906.1 - 0.0042 16.3 1.1 1.4 8.0 0.1 2.8 2 1 1 3 3 3 2 G-protein alpha subunit Pox_A32 PF04665.12 EFE37906.1 - 0.019 14.4 0.1 0.036 13.5 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein RsgA_GTPase PF03193.16 EFE37906.1 - 0.031 14.2 0.1 7.1 6.5 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 EFE37906.1 - 0.034 13.7 0.1 0.056 12.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EFE37906.1 - 0.062 13.0 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFE37906.1 - 0.074 13.1 0.0 0.17 11.9 0.1 1.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 EFE37906.1 - 0.087 13.2 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EFE37906.1 - 0.11 12.6 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EFE37906.1 - 0.16 11.3 0.3 0.25 10.6 0.0 1.5 2 0 0 2 2 2 0 Septin Pkinase PF00069.25 EFE37907.1 - 1.1e-14 54.5 0.0 1.5e-14 54.0 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37907.1 - 1e-10 41.3 0.0 1.4e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EFE37907.1 - 7.8e-05 22.4 0.1 0.00015 21.4 0.1 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EFE37907.1 - 0.019 14.9 0.1 0.029 14.3 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFE37907.1 - 0.11 11.8 0.1 0.27 10.6 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Atg14 PF10186.9 EFE37909.1 - 3.4e-84 282.6 0.0 4.5e-84 282.3 0.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1192 PF06698.11 EFE37909.1 - 0.28 11.3 2.7 0.68 10.0 2.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) BBP1_C PF15272.6 EFE37909.1 - 0.3 10.9 3.0 0.48 10.2 3.0 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal LMBR1 PF04791.16 EFE37911.1 - 3.1e-17 62.7 4.9 3.1e-17 62.7 4.9 2.3 1 1 1 2 2 2 2 LMBR1-like membrane protein DUF5367 PF17329.2 EFE37911.1 - 0.029 14.5 2.0 0.029 14.5 2.0 4.4 7 1 0 7 7 7 0 Family of unknown function (DUF5367) PHINT_rpt PF14882.6 EFE37912.1 - 0.0051 17.0 0.1 0.012 15.9 0.1 1.5 1 0 0 1 1 1 1 Phage-integrase repeat unit AbiEii PF08843.11 EFE37912.1 - 0.039 13.9 0.0 0.053 13.5 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyl transferase AbiEii toxin, Type IV TA system zf-MYND PF01753.18 EFE37913.1 - 1.6e-10 40.9 9.0 3.4e-10 39.8 9.0 1.6 1 0 0 1 1 1 1 MYND finger FlxA PF14282.6 EFE37914.1 - 0.18 11.8 1.6 5.6 7.0 1.1 2.3 2 0 0 2 2 2 0 FlxA-like protein PIG-F PF06699.11 EFE37915.1 - 1.8e-49 168.3 2.5 2.2e-49 168.1 2.5 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F PRA1 PF03208.19 EFE37915.1 - 0.17 11.5 1.3 0.28 10.8 1.3 1.4 1 0 0 1 1 1 0 PRA1 family protein Amidase PF01425.21 EFE37916.1 - 3.9e-81 273.3 0.0 2e-80 271.0 0.0 2.0 1 1 0 1 1 1 1 Amidase ADH_zinc_N PF00107.26 EFE37917.1 - 1.3e-18 67.2 0.2 2.5e-18 66.3 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE37917.1 - 1.7e-12 47.2 0.2 5.1e-12 45.6 0.2 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EFE37917.1 - 0.0011 18.4 0.5 0.0018 17.6 0.5 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 EFE37917.1 - 0.0047 17.2 0.1 0.15 12.3 0.1 2.3 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Pkinase PF00069.25 EFE37918.1 - 2.6e-23 82.8 0.0 4.9e-13 49.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37918.1 - 4.6e-07 29.4 0.0 0.009 15.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFE37921.1 - 7.1e-09 35.9 0.0 5e-08 33.2 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE37921.1 - 0.099 12.2 0.0 0.24 11.0 0.0 1.7 1 1 0 1 1 1 0 Choline/ethanolamine kinase Methyltransf_PK PF05891.12 EFE37923.1 - 1e-07 31.7 0.0 1.1e-07 31.7 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase WD40 PF00400.32 EFE37924.1 - 1.5e-113 367.5 77.7 5.8e-10 39.6 0.1 14.3 15 0 0 15 15 13 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE37924.1 - 3e-33 114.0 23.2 0.003 17.8 0.1 12.3 1 1 11 12 12 12 9 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EFE37924.1 - 6.4e-19 68.5 0.0 1.2e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Nup160 PF11715.8 EFE37924.1 - 1.2e-17 63.8 29.9 0.14 10.7 0.2 11.3 3 3 9 12 12 12 8 Nucleoporin Nup120/160 Ank_2 PF12796.7 EFE37924.1 - 9.4e-14 51.8 1.2 4e-06 27.3 0.1 4.5 4 1 1 5 5 3 2 Ankyrin repeats (3 copies) eIF2A PF08662.11 EFE37924.1 - 1.6e-10 41.2 7.4 0.00081 19.3 0.2 5.2 4 2 2 6 6 6 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFE37924.1 - 6.8e-10 38.4 20.6 0.0028 16.7 2.2 8.3 1 1 4 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Ank_4 PF13637.6 EFE37924.1 - 2.7e-08 34.2 0.0 0.01 16.4 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) WD40_like PF17005.5 EFE37924.1 - 4e-08 32.9 3.2 0.036 13.4 0.1 5.1 5 1 0 5 5 5 2 WD40-like domain Ank PF00023.30 EFE37924.1 - 4.7e-07 30.0 0.2 0.0065 16.9 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 EFE37924.1 - 4.9e-07 29.6 0.0 0.0036 17.7 0.0 4.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 EFE37924.1 - 2.9e-06 27.5 0.0 0.019 15.3 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Nucleoporin_N PF08801.11 EFE37924.1 - 2.1e-05 23.5 20.0 0.055 12.2 0.1 6.0 2 2 3 7 7 7 3 Nup133 N terminal like Cytochrom_D1 PF02239.16 EFE37924.1 - 3.6e-05 22.5 7.6 0.052 12.1 0.5 4.1 3 2 0 3 3 3 2 Cytochrome D1 heme domain AAA_16 PF13191.6 EFE37924.1 - 6.1e-05 23.5 0.0 0.00017 22.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain NACHT_sigma PF17106.5 EFE37924.1 - 0.00091 19.3 3.8 0.0019 18.3 3.8 1.4 1 0 0 1 1 1 1 Sigma domain on NACHT-NTPases DUF5046 PF16465.5 EFE37924.1 - 0.01 15.3 0.1 0.47 9.9 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF5046) AAA_19 PF13245.6 EFE37924.1 - 0.1 12.9 0.0 0.26 11.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF3447 PF11929.8 EFE37924.1 - 1.3 9.0 3.6 1.5e+02 2.4 0.0 5.3 7 1 1 8 8 6 0 Domain of unknown function (DUF3447) SesA PF17107.5 EFE37925.1 - 5.9e-26 91.1 0.0 9.4e-26 90.4 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases NACHT_sigma PF17106.5 EFE37925.1 - 5.1e-10 39.3 10.4 1e-09 38.4 10.4 1.5 1 0 0 1 1 1 1 Sigma domain on NACHT-NTPases Acetyltransf_16 PF05301.11 EFE37925.1 - 0.055 13.2 0.1 0.079 12.7 0.1 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 SesA PF17107.5 EFE37926.1 - 5.1e-39 133.2 0.2 7.5e-39 132.7 0.2 1.2 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases NACHT_sigma PF17106.5 EFE37926.1 - 7.6e-12 45.2 9.6 7.6e-12 45.2 9.6 1.6 2 0 0 2 2 2 1 Sigma domain on NACHT-NTPases DUF2802 PF10975.8 EFE37926.1 - 0.021 15.0 0.1 0.05 13.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) Helo_like_N PF17111.5 EFE37926.1 - 0.021 14.2 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins RhoGAP PF00620.27 EFE37928.1 - 2.4e-38 131.4 0.0 3.7e-38 130.7 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Amidase PF01425.21 EFE37929.1 - 8e-80 269.0 0.4 3.1e-77 260.5 0.1 2.2 2 0 0 2 2 2 2 Amidase NAD_binding_5 PF07994.12 EFE37931.1 - 2.4e-145 483.9 0.1 3e-145 483.6 0.1 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EFE37931.1 - 2.6e-45 153.1 0.6 6e-45 152.0 0.6 1.6 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Ribonucleas_3_3 PF14622.6 EFE37933.1 - 7.9e-07 29.3 0.0 1.2e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EFE37933.1 - 0.00048 20.7 0.0 0.004 17.8 0.0 2.2 1 1 0 1 1 1 1 Ribonuclease III domain Peptidase_S10 PF00450.22 EFE37935.1 - 1.1e-71 242.4 0.2 1.5e-71 242.0 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase LIM PF00412.22 EFE37936.1 - 6.8e-17 61.4 18.5 1.7e-11 44.1 2.8 3.3 3 1 0 3 3 3 2 LIM domain Glyco_hydro_3 PF00933.21 EFE37937.1 - 3.4e-55 187.7 0.0 4.1e-55 187.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain 7TMR-DISM_7TM PF07695.11 EFE37938.1 - 0.12 12.2 24.2 0.24 11.3 12.8 2.2 2 0 0 2 2 2 0 7TM diverse intracellular signalling LapA_dom PF06305.11 EFE37938.1 - 0.16 11.8 1.7 8 6.4 0.1 2.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain COesterase PF00135.28 EFE37939.1 - 7.6e-64 216.4 0.0 2e-55 188.6 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE37939.1 - 1.8e-10 41.1 0.0 2.6e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Cu_amine_oxid PF01179.20 EFE37941.1 - 3.4e-163 543.4 0.3 4e-163 543.1 0.3 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EFE37941.1 - 8.8e-06 26.1 0.0 1.8e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EFE37941.1 - 0.015 15.5 0.0 0.033 14.4 0.0 1.5 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain AMP-binding PF00501.28 EFE37942.1 - 0.01 14.5 0.0 0.011 14.4 0.0 1.2 1 1 0 1 1 1 0 AMP-binding enzyme DNA_pol_B PF00136.21 EFE37942.1 - 0.3 9.7 0.0 0.34 9.6 0.0 1.0 1 0 0 1 1 1 0 DNA polymerase family B AMP-binding PF00501.28 EFE37943.1 - 3.2e-21 75.4 0.2 7.8e-17 61.0 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EFE37943.1 - 1.7e-07 32.1 0.0 2.9e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Fungal_trans PF04082.18 EFE37944.1 - 1.1e-07 31.2 0.0 2.3e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain adh_short_C2 PF13561.6 EFE37945.1 - 8.7e-55 185.8 0.8 3.4e-54 183.9 0.8 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE37945.1 - 2.3e-34 118.6 0.2 3.3e-34 118.1 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE37945.1 - 8.2e-05 22.6 0.8 0.00022 21.2 0.1 1.9 2 0 0 2 2 2 1 KR domain MFS_1 PF07690.16 EFE37948.1 - 5.7e-11 41.9 26.5 4.7e-10 38.9 17.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFE37948.1 - 0.32 9.8 10.2 0.16 10.8 6.1 2.3 2 1 1 3 3 3 0 MFS_1 like family Tr-sialidase_C PF11052.8 EFE37948.1 - 0.45 10.7 3.8 12 6.1 0.2 2.7 2 0 0 2 2 2 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal Aldedh PF00171.22 EFE37950.1 - 7.7e-74 248.9 0.0 1.1e-69 235.2 0.0 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Adap_comp_sub PF00928.21 EFE37951.1 - 1.1e-61 208.5 0.0 1.4e-61 208.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family DUF4588 PF15251.6 EFE37952.1 - 1.6e-05 24.8 1.8 2.7e-05 24.0 0.1 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4588) SNF2_N PF00176.23 EFE37953.1 - 2.7e-75 253.3 0.1 4.9e-75 252.4 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EFE37953.1 - 2.3e-43 146.8 0.9 2.3e-43 146.8 0.9 2.2 2 0 0 2 2 2 1 SLIDE HAND PF09110.11 EFE37953.1 - 7.8e-31 107.1 4.6 7.8e-31 107.1 4.6 3.8 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 EFE37953.1 - 6.5e-18 65.1 0.6 3e-17 63.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE37953.1 - 5.2e-11 42.8 0.1 6.5e-10 39.3 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EFE37953.1 - 2.5e-06 26.9 0.1 1.1e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EFE37953.1 - 0.00033 20.4 0.0 0.0019 17.9 0.0 2.3 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DEAD PF00270.29 EFE37953.1 - 0.00062 19.6 0.0 0.0015 18.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 EFE37953.1 - 0.0019 18.3 0.0 4 7.7 0.0 3.0 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF1086 PF06461.11 EFE37953.1 - 0.0041 17.0 0.1 0.011 15.6 0.1 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) AAA_14 PF13173.6 EFE37953.1 - 0.028 14.5 0.4 0.14 12.2 0.0 2.4 2 0 0 2 2 1 0 AAA domain DEAD_2 PF06733.15 EFE37953.1 - 0.037 13.6 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 DEAD_2 Ku_C PF03730.14 EFE37953.1 - 0.049 14.3 0.4 0.049 14.3 0.4 3.5 4 0 0 4 4 3 0 Ku70/Ku80 C-terminal arm Occludin_ELL PF07303.13 EFE37953.1 - 0.17 12.6 3.2 0.64 10.8 3.2 2.0 1 0 0 1 1 1 0 Occludin homology domain SpoU_methylase PF00588.19 EFE37954.1 - 6.2e-25 88.0 0.0 1.3e-24 87.0 0.0 1.5 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EFE37954.1 - 4.7e-09 36.4 0.0 9e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding zf-PHD-like PF15446.6 EFE37955.1 - 3.8e-64 215.4 11.1 8.2e-64 214.3 11.1 1.6 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 EFE37955.1 - 1e-52 179.0 1.3 1.6e-52 178.4 1.3 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-CCCH_6 PF18585.1 EFE37955.1 - 3.2e-25 87.7 0.8 9.9e-25 86.2 0.8 1.9 1 0 0 1 1 1 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Helicase_C PF00271.31 EFE37955.1 - 1.6e-18 67.1 0.0 4.8e-18 65.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EFE37955.1 - 1.5e-09 37.5 2.9 4.4e-09 35.9 2.9 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EFE37955.1 - 1.8e-09 37.8 0.0 9.8e-09 35.4 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Chromo PF00385.24 EFE37955.1 - 1.9e-06 27.7 3.1 0.019 14.9 0.5 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 EFE37955.1 - 8.5e-06 25.6 16.8 1.4e-05 24.9 2.6 3.8 2 1 0 2 2 2 1 PHD-finger DEAD PF00270.29 EFE37955.1 - 0.00024 20.9 0.0 0.0005 19.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1087 PF06465.13 EFE37955.1 - 0.0034 17.4 0.6 0.012 15.6 0.1 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1087) DEAD_2 PF06733.15 EFE37955.1 - 0.017 14.8 0.1 0.063 12.9 0.0 2.0 2 0 0 2 2 2 0 DEAD_2 SnAC PF14619.6 EFE37955.1 - 0.45 11.2 7.6 0.58 10.8 0.4 4.1 4 0 0 4 4 3 0 Snf2-ATP coupling, chromatin remodelling complex FANCL_C PF11793.8 EFE37955.1 - 0.86 9.8 3.6 3.2 8.0 3.6 2.0 1 0 0 1 1 1 0 FANCL C-terminal domain Zf_RING PF16744.5 EFE37955.1 - 4.5 7.5 9.6 30 4.8 0.3 3.1 2 0 0 2 2 2 0 KIAA1045 RING finger Na_Ca_ex PF01699.24 EFE37956.1 - 0.00062 19.8 3.0 0.00062 19.8 3.0 1.7 2 0 0 2 2 2 1 Sodium/calcium exchanger protein HNH_2 PF13391.6 EFE37957.1 - 0.0004 20.5 0.0 0.00091 19.3 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease MFS_1 PF07690.16 EFE37959.1 - 3e-11 42.9 11.4 3.2e-11 42.8 11.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE37959.1 - 0.0032 16.4 4.9 0.0043 16.0 4.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter DAO PF01266.24 EFE37960.1 - 1.5e-31 110.2 0.2 2.3e-31 109.6 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE37960.1 - 0.006 16.8 0.0 0.025 14.8 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain ThiF PF00899.21 EFE37960.1 - 0.026 13.9 0.5 0.039 13.3 0.0 1.5 2 0 0 2 2 2 0 ThiF family NAD_binding_9 PF13454.6 EFE37960.1 - 0.037 14.0 0.2 0.23 11.4 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EFE37960.1 - 0.04 13.2 0.0 0.06 12.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EFE37960.1 - 0.044 13.8 0.0 0.073 13.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EFE37960.1 - 0.086 11.9 1.3 0.29 10.2 1.3 1.8 1 1 0 1 1 1 0 FAD binding domain TadE PF07811.12 EFE37960.1 - 5 7.5 5.4 1.3 9.4 0.7 2.1 2 0 0 2 2 2 0 TadE-like protein Thioredoxin PF00085.20 EFE37961.1 - 3.1e-26 91.3 0.0 5.7e-24 84.1 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 EFE37961.1 - 1.3e-09 38.3 0.0 0.00011 22.2 0.0 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain HyaE PF07449.11 EFE37961.1 - 0.00075 19.4 0.0 0.45 10.5 0.0 2.7 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE Thioredoxin_2 PF13098.6 EFE37961.1 - 0.0042 17.5 0.1 1 9.8 0.1 2.9 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFE37961.1 - 0.0044 17.3 0.0 0.38 11.1 0.0 2.9 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EFE37961.1 - 0.034 14.3 0.2 0.24 11.6 0.1 2.3 2 0 0 2 2 2 0 Thioredoxin-like Thioredoxin_3 PF13192.6 EFE37961.1 - 0.035 14.1 0.2 0.16 12.0 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin domain TraF PF13728.6 EFE37961.1 - 0.28 11.0 0.0 0.28 11.0 0.0 2.6 3 0 0 3 3 3 0 F plasmid transfer operon protein ETC_C1_NDUFA5 PF04716.14 EFE37962.1 - 3.7e-26 90.7 5.9 1.2e-25 89.1 0.1 2.8 3 0 0 3 3 3 2 ETC complex I subunit conserved region DUF1192 PF06698.11 EFE37962.1 - 0.059 13.4 0.3 0.17 12.0 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Angiomotin_C PF12240.8 EFE37962.1 - 0.086 12.4 3.2 0.13 11.8 3.2 1.2 1 0 0 1 1 1 0 Angiomotin C terminal MT PF12777.7 EFE37962.1 - 0.14 11.2 0.7 0.19 10.7 0.7 1.3 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor Coatomer_WDAD PF04053.14 EFE37963.1 - 1.7e-154 515.2 0.0 2.9e-151 504.5 0.0 2.6 2 1 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EFE37963.1 - 1.8e-34 117.1 6.2 2.6e-06 28.0 0.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 EFE37963.1 - 0.00072 18.3 1.3 0.25 10.0 0.1 3.5 2 1 1 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFE37963.1 - 0.0019 18.5 0.1 4.6 7.6 0.0 4.3 2 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFE37963.1 - 0.092 12.8 0.0 17 5.5 0.0 3.4 2 2 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Pkinase PF00069.25 EFE37964.1 - 4.5e-66 222.9 0.0 6.1e-66 222.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE37964.1 - 3.3e-30 105.2 0.0 2.9e-20 72.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EFE37964.1 - 1.7e-10 41.4 1.2 3.3e-10 40.5 0.2 2.1 2 1 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EFE37964.1 - 3.6e-06 26.2 0.1 5.4e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain C2 PF00168.30 EFE37964.1 - 0.026 14.8 0.0 0.056 13.7 0.0 1.5 1 0 0 1 1 1 0 C2 domain Kinase-like PF14531.6 EFE37964.1 - 0.21 10.8 0.0 16 4.7 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Myb_DNA-binding PF00249.31 EFE37965.1 - 5.1e-10 39.4 0.0 1.7e-09 37.7 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 EFE37965.1 - 0.0032 17.8 0.0 0.0099 16.2 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain PG_binding_1 PF01471.18 EFE37965.1 - 0.022 15.0 0.0 0.079 13.2 0.0 2.0 1 0 0 1 1 1 0 Putative peptidoglycan binding domain DUF5112 PF17139.4 EFE37965.1 - 0.053 13.0 0.7 0.079 12.4 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5112) WD40 PF00400.32 EFE37967.1 - 7.5e-10 39.3 8.7 0.0088 16.9 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat Glycos_transf_4 PF00953.21 EFE37968.1 - 2.1e-25 89.6 7.3 2.1e-25 89.6 7.3 2.0 2 1 0 2 2 2 1 Glycosyl transferase family 4 Aconitase PF00330.20 EFE37969.1 - 3.5e-159 530.7 0.1 4.6e-159 530.3 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFE37969.1 - 1.1e-40 139.0 0.0 1.9e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Pribosyltran PF00156.27 EFE37970.1 - 8e-14 51.5 0.3 1.6e-13 50.5 0.3 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PBP1_TM PF14812.6 EFE37970.1 - 0.0069 16.7 3.7 0.015 15.6 3.7 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal RPA43_OB PF17875.1 EFE37970.1 - 0.038 14.6 0.7 0.076 13.6 0.7 1.4 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I MTHFR PF02219.17 EFE37971.1 - 7e-116 386.6 0.0 1e-115 386.0 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF1804 PF08822.11 EFE37971.1 - 0.058 13.4 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) DUF2418 PF10332.9 EFE37973.1 - 2.9e-35 120.7 0.1 6.9e-35 119.5 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) PP1_bind PF15276.6 EFE37973.1 - 0.096 13.0 1.9 11 6.4 0.0 3.0 1 1 1 2 2 2 0 Protein phosphatase 1 binding E1_DerP2_DerF2 PF02221.15 EFE37974.1 - 1.6e-21 77.1 0.3 7e-20 71.8 0.3 2.0 1 1 0 1 1 1 1 ML domain TRP_N PF14558.6 EFE37974.1 - 0.00027 21.3 0.0 0.0005 20.4 0.0 1.5 1 1 0 1 1 1 1 ML-like domain NOGCT PF08155.11 EFE37975.1 - 3.2e-29 100.7 1.5 7.7e-29 99.4 1.5 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1_N PF17835.1 EFE37975.1 - 7.2e-29 100.8 2.7 2.5e-22 79.6 0.1 3.1 3 0 0 3 3 3 2 NOG1 N-terminal helical domain NOG1 PF06858.14 EFE37975.1 - 3.6e-26 90.7 0.5 7.8e-26 89.6 0.5 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EFE37975.1 - 1.5e-15 57.3 0.0 3.9e-15 55.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFE37975.1 - 8e-08 32.0 0.0 3.1e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFE37975.1 - 0.00018 21.5 0.4 0.058 13.3 0.0 3.3 3 1 0 3 3 3 1 RsgA GTPase Dynamin_N PF00350.23 EFE37975.1 - 0.0043 17.1 0.0 1.3 9.0 0.0 2.8 1 1 1 2 2 2 1 Dynamin family AAA_16 PF13191.6 EFE37975.1 - 0.026 14.9 1.3 0.16 12.4 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 EFE37975.1 - 0.16 12.2 0.0 0.94 9.7 0.0 2.1 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Acetyltransf_10 PF13673.7 EFE37976.1 - 1.5e-12 47.6 0.0 2.2e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE37976.1 - 2.7e-10 40.5 0.0 3.8e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFE37976.1 - 1.4e-07 31.8 0.0 2.6e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE37976.1 - 0.00011 22.0 0.0 0.0002 21.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein MOZ_SAS PF01853.18 EFE37976.1 - 0.17 11.5 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 MOZ/SAS family Acetyltransf_CG PF14542.6 EFE37976.1 - 0.17 12.0 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 EFE37976.1 - 0.25 11.5 0.0 0.37 10.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DNA_pol_phi PF04931.13 EFE37976.1 - 0.4 8.7 4.1 0.51 8.4 4.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi PGA2 PF07543.12 EFE37976.1 - 1.3 9.0 2.7 2.2 8.2 2.7 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF2457 PF10446.9 EFE37976.1 - 1.6 7.8 8.4 2.4 7.2 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_dimeris PF09026.10 EFE37976.1 - 2.1 8.8 11.3 4.2 7.8 11.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 EFE37976.1 - 4.6 6.9 6.1 7 6.3 6.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Asp_protease PF09668.10 EFE37977.1 - 4.8e-61 204.0 0.2 7.5e-61 203.4 0.2 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EFE37977.1 - 2e-22 79.6 0.0 4.7e-22 78.4 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease ubiquitin PF00240.23 EFE37977.1 - 1.6e-10 40.6 0.0 2.5e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Asp_protease_2 PF13650.6 EFE37977.1 - 2.6e-10 40.8 0.1 1.4e-09 38.5 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease UBA PF00627.31 EFE37977.1 - 5.4e-07 29.4 0.0 1.1e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 EFE37977.1 - 0.0023 17.7 0.0 0.0052 16.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_4 PF14555.6 EFE37977.1 - 0.0046 16.7 0.1 0.0089 15.8 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain UN_NPL4 PF11543.8 EFE37977.1 - 0.0055 17.2 0.0 0.011 16.2 0.0 1.5 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 RVP_2 PF08284.11 EFE37977.1 - 0.011 15.5 0.1 0.028 14.2 0.1 1.6 1 1 0 1 1 1 0 Retroviral aspartyl protease RVP PF00077.20 EFE37977.1 - 0.077 13.3 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease Fungal_trans_2 PF11951.8 EFE37978.1 - 2e-18 66.4 1.2 6.1e-14 51.6 1.1 2.9 3 0 0 3 3 3 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE37978.1 - 4.6e-07 29.8 11.9 1e-06 28.8 11.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Afi1 PF07792.12 EFE37979.1 - 9.1 6.8 6.4 2.9 8.4 1.4 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking zf-C2H2 PF00096.26 EFE37980.1 - 0.00057 20.2 5.3 0.39 11.2 0.2 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 EFE37980.1 - 0.0012 19.0 0.2 0.0018 18.4 0.2 1.2 1 0 0 1 1 1 1 Aberrant zinc-finger zf-C2H2_4 PF13894.6 EFE37980.1 - 0.016 16.0 3.7 0.086 13.7 0.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger PRP38_assoc PF12871.7 EFE37981.1 - 1.3 9.7 36.8 1.8 9.2 36.8 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Pes-10 PF07149.11 EFE37981.1 - 3.9 6.4 15.9 4.8 6.1 15.9 1.0 1 0 0 1 1 1 0 Pes-10 CDC45 PF02724.14 EFE37981.1 - 4.2 5.6 24.3 4.5 5.5 24.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EFE37981.1 - 9.1 4.9 12.3 11 4.7 12.3 1.0 1 0 0 1 1 1 0 Presenilin Not3 PF04065.15 EFE37982.1 - 4.5e-87 291.3 15.3 6.6e-87 290.8 15.3 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EFE37982.1 - 2.6e-42 144.0 11.5 6.2e-42 142.8 11.5 1.7 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family CLZ PF16526.5 EFE37982.1 - 0.017 15.5 2.1 0.042 14.2 0.5 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF2373 PF10180.9 EFE37982.1 - 0.061 13.2 4.7 0.16 11.8 4.7 1.7 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) Syntaxin_2 PF14523.6 EFE37982.1 - 0.56 10.6 8.1 0.068 13.5 2.1 2.5 2 0 0 2 2 2 0 Syntaxin-like protein Tyr_Deacylase PF02580.16 EFE37983.1 - 3.1e-45 154.2 0.0 4e-45 153.9 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Pro_isomerase PF00160.21 EFE37984.1 - 7e-35 120.6 0.3 1.4e-34 119.7 0.1 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EFE37984.1 - 5.2e-06 26.2 6.4 0.00017 21.4 2.3 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFE37984.1 - 0.00016 21.3 1.2 0.00016 21.3 1.2 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFE37984.1 - 0.0032 18.1 7.4 0.06 14.0 6.6 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFE37984.1 - 0.0048 17.0 1.4 0.59 10.3 0.9 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFE37984.1 - 0.02 15.1 3.0 0.062 13.5 0.6 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFE37984.1 - 0.3 12.0 4.7 0.39 11.7 2.1 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFE37984.1 - 2.2 8.1 6.9 27 4.5 0.4 3.3 3 0 0 3 3 3 0 TPR repeat FmdA_AmdA PF03069.15 EFE37985.1 - 1.5e-168 560.4 0.0 1.7e-168 560.2 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family TNT PF14021.6 EFE37986.1 - 5.3e-29 100.6 0.0 7.6e-29 100.1 0.0 1.2 1 0 0 1 1 1 1 Tuberculosis necrotizing toxin DUF2841 PF11001.8 EFE37988.1 - 2.4e-33 114.8 0.0 4.3e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Helo_like_N PF17111.5 EFE37990.1 - 0.041 13.3 0.3 0.18 11.2 0.2 1.9 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins Pol_alpha_B_N PF08418.10 EFE37990.1 - 0.072 13.0 4.3 0.036 14.0 2.0 1.7 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal MRNIP PF15749.5 EFE37990.1 - 0.18 12.6 2.3 0.6 10.9 0.0 2.4 2 0 0 2 2 2 0 MRN-interacting protein Sugar_tr PF00083.24 EFE37991.1 - 4.2e-44 151.1 22.1 1.5e-27 96.6 6.1 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 EFE37991.1 - 4.9e-23 81.6 22.8 3.3e-21 75.6 20.4 2.9 2 1 0 2 2 2 2 Major Facilitator Superfamily EI24 PF07264.11 EFE37993.1 - 6.4e-12 46.1 5.6 1.1e-09 38.7 5.6 2.3 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF3742 PF12553.8 EFE37993.1 - 0.35 11.0 0.1 0.35 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) Inp1 PF12634.7 EFE37994.1 - 5.6e-38 130.0 0.1 1.2e-37 129.0 0.0 1.6 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 SRP14 PF02290.15 EFE37995.1 - 3.9e-29 100.9 0.0 5.2e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle 14kD protein MIF4G PF02854.19 EFE37996.1 - 4.6e-23 82.0 4.3 6.2e-22 78.3 3.6 2.4 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 EFE37996.1 - 5e-17 61.9 0.0 1.9e-16 60.1 0.0 2.1 1 0 0 1 1 1 1 MA3 domain EST1_DNA_bind PF10373.9 EFE37996.1 - 0.00056 19.5 1.0 0.0013 18.3 1.0 1.5 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain Hydrolase_like PF13242.6 EFE37997.1 - 0.00019 21.4 0.0 0.0004 20.4 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Plus-3 PF03126.18 EFE37997.1 - 0.11 13.1 0.0 0.35 11.4 0.0 1.8 2 0 0 2 2 2 0 Plus-3 domain MRC1 PF09444.10 EFE37999.1 - 1e-41 142.8 21.3 1e-41 142.8 21.3 6.3 5 2 1 6 6 6 1 MRC1-like domain Bromodomain PF00439.25 EFE38000.1 - 4.6e-38 129.2 3.4 3.9e-20 71.7 0.2 2.5 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EFE38000.1 - 3.5e-17 62.4 0.8 8e-17 61.2 0.8 1.7 1 0 0 1 1 1 1 BAH domain DUF2052 PF09747.9 EFE38000.1 - 0.009 16.2 4.2 0.009 16.2 4.2 2.5 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) Nucleo_P87 PF07267.11 EFE38000.1 - 0.049 12.5 15.1 0.0055 15.6 3.5 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 EFE38000.1 - 2.7 6.2 14.2 0.016 13.6 4.6 1.9 2 0 0 2 2 2 0 CDC45-like protein OTU PF02338.19 EFE38001.1 - 3.3e-07 30.8 0.0 5.9e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease UN_NPL4 PF11543.8 EFE38001.1 - 0.033 14.7 0.0 0.074 13.5 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 APC_r PF05923.12 EFE38001.1 - 0.23 11.2 1.0 0.47 10.2 1.0 1.6 1 0 0 1 1 1 0 APC repeat IBR PF01485.21 EFE38002.1 - 0.00045 20.4 6.7 0.00045 20.4 6.7 5.9 4 1 0 4 4 4 1 IBR domain, a half RING-finger domain IL4 PF00727.18 EFE38002.1 - 0.015 15.5 0.0 5.3 7.3 0.0 2.8 2 0 0 2 2 2 0 Interleukin 4 VWA_2 PF13519.6 EFE38002.1 - 0.015 15.9 0.0 0.034 14.8 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain RecR PF02132.15 EFE38002.1 - 6.9 6.3 9.6 1.5 8.4 1.5 3.8 3 1 0 3 3 3 0 RecR protein Fungal_trans PF04082.18 EFE38003.1 - 2.6e-11 43.1 0.4 4.6e-11 42.3 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE38003.1 - 2.3e-10 40.4 10.5 4.6e-10 39.5 10.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA_12 PF13087.6 EFE38004.1 - 4.6e-31 108.0 0.0 9.4e-31 107.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFE38004.1 - 3.1e-16 59.9 4.6 1.1e-11 45.0 0.0 2.7 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 EFE38004.1 - 1.1e-07 32.3 0.0 2.3e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 EFE38004.1 - 0.00053 19.6 0.0 0.0014 18.3 0.0 1.6 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 EFE38004.1 - 0.0009 19.0 0.0 0.0027 17.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EFE38004.1 - 0.0017 18.1 0.1 0.76 9.5 0.0 3.1 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EFE38004.1 - 0.059 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit C2 PF00168.30 EFE38005.1 - 4.1e-15 55.9 0.0 6.7e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain UTP15_C PF09384.10 EFE38006.1 - 1.1e-51 174.4 0.0 2e-51 173.6 0.0 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EFE38006.1 - 3.9e-17 62.3 3.8 0.00042 21.1 0.1 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE38006.1 - 5.5e-07 29.8 0.1 0.13 12.6 0.0 4.0 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EFE38006.1 - 0.00083 19.0 0.7 0.016 14.8 0.1 2.4 1 1 1 2 2 2 1 PQQ-like domain RAB3GAP2_N PF14655.6 EFE38006.1 - 0.018 14.3 0.1 6.5 5.9 0.1 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Nup160 PF11715.8 EFE38006.1 - 0.033 12.8 0.6 1.3 7.6 0.1 2.6 2 1 1 3 3 3 0 Nucleoporin Nup120/160 PhyH PF05721.13 EFE38007.1 - 1e-42 146.8 0.0 1.3e-42 146.5 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EFE38007.1 - 0.14 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase MFS_MOT1 PF16983.5 EFE38009.1 - 1.1e-57 193.2 33.9 1.2e-30 106.1 9.4 3.2 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily Lipase_GDSL_2 PF13472.6 EFE38010.1 - 9.4e-08 32.7 0.0 1.2e-07 32.3 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFE38010.1 - 0.0085 16.1 0.0 0.011 15.7 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Chitin_synth_1 PF01644.17 EFE38011.1 - 3.1e-73 245.1 0.0 4.9e-73 244.5 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EFE38011.1 - 7.1e-30 102.8 0.0 1.6e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EFE38011.1 - 4.8e-21 75.0 4.1 1.6e-17 63.4 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EFE38011.1 - 0.00053 20.0 13.0 0.00053 20.0 13.0 3.1 2 1 0 2 2 2 1 Glycosyl transferase family group 2 LMWPc PF01451.21 EFE38012.1 - 6.3e-25 88.2 0.0 7.4e-25 88.0 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase COQ7 PF03232.13 EFE38013.1 - 2.9e-68 229.0 0.4 3.5e-68 228.7 0.4 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Dehydrin PF00257.19 EFE38013.1 - 0.004 17.7 0.5 0.0068 17.0 0.1 1.6 2 0 0 2 2 2 1 Dehydrin Rubrerythrin PF02915.17 EFE38013.1 - 0.0051 17.2 0.1 0.014 15.8 0.0 1.7 2 0 0 2 2 2 1 Rubrerythrin Crr6 PF08847.11 EFE38013.1 - 0.024 14.3 0.1 1.3 8.7 0.0 2.3 1 1 1 2 2 2 0 Chlororespiratory reduction 6 Plus-3 PF03126.18 EFE38015.1 - 3.3e-18 66.2 0.2 5.1e-11 43.1 0.0 3.5 3 1 1 4 4 4 2 Plus-3 domain Oxysterol_BP PF01237.18 EFE38016.1 - 9.4e-120 399.8 0.0 1.8e-119 398.9 0.0 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 EFE38016.1 - 1.6e-39 134.1 1.0 4.5e-39 132.6 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 EFE38016.1 - 5.6e-06 26.8 0.6 2.6e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EFE38016.1 - 0.58 10.6 3.5 19 5.7 0.8 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain ECR1_N PF14382.6 EFE38017.1 - 1e-14 54.0 0.6 2.5e-14 52.8 0.6 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EFE38017.1 - 6.7e-06 26.4 0.2 1.2e-05 25.5 0.2 1.4 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 EFE38017.1 - 0.67 10.6 0.1 0.67 10.6 0.1 2.8 4 0 0 4 4 4 0 Exosome component EXOSC1/CSL4 Dynamin_N PF00350.23 EFE38018.1 - 1.4e-35 122.9 0.1 2.8e-35 121.9 0.1 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFE38018.1 - 7.1e-27 94.3 0.5 5.7e-20 71.7 0.2 2.5 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EFE38018.1 - 1.4e-05 25.2 0.0 5.2e-05 23.3 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 EFE38018.1 - 0.0015 18.6 2.3 0.032 14.4 0.4 2.7 2 0 0 2 2 2 1 Dynamin GTPase effector domain Roc PF08477.13 EFE38018.1 - 0.0063 16.7 0.2 0.79 9.9 0.0 3.5 4 0 0 4 4 4 1 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 EFE38018.1 - 0.032 14.0 4.5 0.067 12.9 0.5 2.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_16 PF13191.6 EFE38018.1 - 0.041 14.3 0.1 0.61 10.5 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain FeoB_N PF02421.18 EFE38018.1 - 0.095 12.2 0.1 8.9 5.8 0.1 2.7 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_29 PF13555.6 EFE38018.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFE38018.1 - 0.95 9.9 0.0 0.95 9.9 0.0 2.6 2 1 0 2 2 2 0 AAA domain FAD_binding_4 PF01565.23 EFE38019.1 - 9e-19 67.6 0.4 1.6e-18 66.8 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE38019.1 - 4.1e-10 39.6 0.1 1.4e-09 37.9 0.1 2.0 2 0 0 2 2 2 1 Berberine and berberine like Ino80_Iec3 PF14612.6 EFE38020.1 - 1.5e-71 241.8 6.9 2.2e-71 241.3 6.9 1.2 1 0 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling IHABP4_N PF16174.5 EFE38020.1 - 1 10.0 13.6 15 6.2 10.4 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal RRM_1 PF00076.22 EFE38021.1 - 1.4e-25 88.8 0.1 4.1e-14 52.1 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFE38021.1 - 0.00022 21.3 0.2 0.057 13.5 0.0 3.2 3 1 0 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EFE38021.1 - 0.061 13.3 0.0 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 EFE38021.1 - 0.08 12.7 0.0 2.5 7.9 0.0 2.4 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Spt5_N PF11942.8 EFE38021.1 - 1.7 9.7 15.3 0.13 13.3 10.3 1.7 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal PBP1_TM PF14812.6 EFE38021.1 - 3 8.3 8.3 0.18 12.2 0.9 2.7 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CAC1F_C PF16885.5 EFE38021.1 - 4.3 6.9 12.5 1.4 8.5 7.1 2.1 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term CDC45 PF02724.14 EFE38021.1 - 4.4 5.5 11.0 0.42 8.8 6.1 1.6 2 0 0 2 2 2 0 CDC45-like protein Vac7 PF12751.7 EFE38023.1 - 0.019 14.4 0.0 0.021 14.3 0.0 1.0 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Consortin_C PF15281.6 EFE38023.1 - 0.024 14.6 0.8 0.04 13.9 0.5 1.5 1 1 0 1 1 1 0 Consortin C-terminus Btz PF09405.10 EFE38024.1 - 2.2e-22 79.7 3.2 2.2e-22 79.7 3.2 2.5 4 0 0 4 4 4 1 CASC3/Barentsz eIF4AIII binding UBA2_C PF16195.5 EFE38024.1 - 2.2 9.0 9.4 0.12 13.1 2.5 2.5 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus SUIM_assoc PF16619.5 EFE38024.1 - 2.3 8.3 41.3 1.6 8.9 8.9 5.0 4 1 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Rtf2 PF04641.12 EFE38025.1 - 9.7 5.5 18.1 10 5.4 18.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger HMA PF00403.26 EFE38026.1 - 2e-50 169.1 0.4 6.2e-12 45.8 0.0 4.5 4 0 0 4 4 4 4 Heavy-metal-associated domain E1-E2_ATPase PF00122.20 EFE38026.1 - 1.1e-47 161.9 1.4 4.2e-47 160.0 1.4 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFE38026.1 - 4.8e-35 121.8 0.6 1.2e-34 120.5 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFE38026.1 - 1.1e-05 25.3 0.0 0.0056 16.5 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase B12-binding PF02310.19 EFE38026.1 - 0.0092 16.0 0.0 5.7 7.0 0.0 4.5 5 0 0 5 5 5 1 B12 binding domain CSN7a_helixI PF18392.1 EFE38027.1 - 0.0019 18.1 0.0 0.0019 18.1 0.0 2.3 2 1 0 2 2 2 1 COP9 signalosome complex subunit 7a helix I domain PCI PF01399.27 EFE38027.1 - 0.014 15.9 0.0 0.024 15.1 0.0 1.3 1 0 0 1 1 1 0 PCI domain AP3D1 PF06375.11 EFE38027.1 - 0.59 10.4 14.0 1.2 9.3 14.0 1.5 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 XRN_M PF17846.1 EFE38027.1 - 1.8 7.5 5.2 2.7 6.9 5.2 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Rsc14 PF08586.10 EFE38027.1 - 2.2 9.1 4.8 5.7 7.8 4.8 1.6 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit Vfa1 PF08432.10 EFE38027.1 - 5.1 7.4 16.0 18 5.6 11.1 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 EFE38027.1 - 9.2 6.0 13.0 14 5.4 13.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RGS PF00615.19 EFE38028.1 - 5.2e-13 49.3 0.0 4e-09 36.8 0.0 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain Bromodomain PF00439.25 EFE38029.1 - 1.1e-24 86.2 1.0 2.3e-24 85.3 1.0 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EFE38029.1 - 3.3e-08 33.8 0.0 6.3e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE38029.1 - 1.1e-06 28.6 0.1 2e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE38029.1 - 0.00037 20.9 0.1 0.00066 20.1 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Rad1 PF02144.16 EFE38030.1 - 8.5e-89 297.3 0.1 9.9e-89 297.0 0.1 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 SbcCD_C PF13558.6 EFE38031.1 - 8.2e-07 29.2 0.0 2.3e-06 27.7 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EFE38031.1 - 9.3e-06 26.3 9.6 9.3e-06 26.3 9.6 7.7 1 1 1 2 2 2 1 AAA domain DASH_Dam1 PF08653.10 EFE38031.1 - 0.14 12.0 0.1 0.14 12.0 0.1 5.9 6 0 0 6 6 6 0 DASH complex subunit Dam1 PPP4R2 PF09184.11 EFE38032.1 - 3.3e-10 40.0 0.0 6.2e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 PPP4R2 zf-C2H2 PF00096.26 EFE38034.1 - 1.6e-12 47.1 13.9 3.9e-06 27.0 2.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE38034.1 - 7.4e-11 42.0 10.1 1.4e-06 28.4 0.2 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE38034.1 - 1.4e-08 34.8 11.4 0.00092 19.9 1.6 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFE38034.1 - 8.4e-07 28.8 5.2 0.0022 17.9 0.5 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFE38034.1 - 4.9e-06 26.7 0.2 0.067 13.5 0.2 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFE38034.1 - 0.00017 21.9 1.4 0.013 15.9 0.3 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EFE38034.1 - 0.00031 20.5 5.6 0.095 12.5 0.6 3.4 3 0 0 3 3 3 1 zinc-finger C2H2-type Zn_ribbon_recom PF13408.6 EFE38034.1 - 0.019 15.4 1.3 0.048 14.2 1.3 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-Di19 PF05605.12 EFE38034.1 - 0.097 13.0 1.6 0.19 12.1 1.6 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 EFE38034.1 - 0.16 12.5 2.1 4.1 7.9 0.4 2.7 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger LIM PF00412.22 EFE38034.1 - 0.74 10.1 2.3 14 6.0 0.2 2.4 1 1 1 2 2 2 0 LIM domain C5HCH PF17982.1 EFE38034.1 - 2.4 8.4 6.3 18 5.6 1.2 2.6 1 1 1 2 2 2 0 NSD Cys-His rich domain Pkinase PF00069.25 EFE38035.1 - 6e-52 176.6 0.1 1.2e-33 116.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38035.1 - 1.4e-25 90.0 0.0 4.8e-24 85.0 0.0 3.1 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE38035.1 - 7.3e-05 21.7 0.0 0.00022 20.1 0.0 1.8 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFE38035.1 - 0.001 19.0 0.1 0.0067 16.4 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFE38035.1 - 0.0017 17.7 0.0 0.0048 16.3 0.0 1.5 1 1 0 1 1 1 1 Kinase-like SH3_1 PF00018.28 EFE38037.1 - 1.8e-14 53.0 0.0 2.8e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE38037.1 - 1.5e-12 47.2 0.0 4.7e-12 45.6 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EFE38037.1 - 1.2e-07 31.3 0.0 2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SAS4 PF15460.6 EFE38039.1 - 1.1e-31 108.9 4.3 1.1e-31 108.9 4.3 2.1 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 CENP-B_dimeris PF09026.10 EFE38039.1 - 0.0074 16.7 13.2 0.017 15.5 13.2 1.6 1 0 0 1 1 1 1 Centromere protein B dimerisation domain TFIIF_alpha PF05793.12 EFE38039.1 - 0.11 11.1 18.5 0.2 10.2 18.5 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BT1 PF03092.16 EFE38039.1 - 0.42 8.8 0.8 0.62 8.2 0.8 1.2 1 0 0 1 1 1 0 BT1 family NOA36 PF06524.12 EFE38039.1 - 0.92 8.8 12.8 1.8 7.8 12.8 1.4 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EFE38039.1 - 1.5 6.9 19.0 2.3 6.2 19.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 EFE38039.1 - 1.7 6.8 16.8 3.6 5.8 16.8 1.5 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFE38039.1 - 2.2 6.4 24.2 3.5 5.7 24.2 1.2 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 EFE38039.1 - 8.4 5.5 7.8 17 4.5 7.8 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Protocadherin PF08374.11 EFE38040.1 - 0.012 15.5 2.5 0.016 15.2 2.5 1.1 1 0 0 1 1 1 0 Protocadherin PTPRCAP PF15713.5 EFE38040.1 - 0.021 15.1 1.2 0.028 14.7 1.2 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Brix PF04427.18 EFE38042.1 - 8.9e-37 127.1 0.0 1.2e-36 126.7 0.0 1.2 1 0 0 1 1 1 1 Brix domain SH3_9 PF14604.6 EFE38043.1 - 6.4e-30 102.8 3.6 3.8e-14 52.3 0.4 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EFE38043.1 - 1.8e-29 101.0 4.2 1.8e-14 53.0 0.4 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EFE38043.1 - 6.5e-16 57.8 0.0 2.6e-07 30.2 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.20 EFE38043.1 - 7.3e-16 58.1 0.0 1.3e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Dynamin_M PF01031.20 EFE38044.1 - 6.2e-111 370.2 0.0 1e-110 369.4 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EFE38044.1 - 3.1e-57 193.3 0.5 2.7e-56 190.3 0.1 2.5 3 0 0 3 3 3 1 Dynamin family GED PF02212.18 EFE38044.1 - 1e-31 108.9 0.8 2.4e-31 107.7 0.8 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EFE38044.1 - 0.00018 21.5 0.6 0.0017 18.4 0.6 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.6 EFE38044.1 - 0.057 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system LYRIC PF15686.5 EFE38044.1 - 2.5 7.6 11.8 6.3 6.3 1.6 2.2 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family zf-C2H2 PF00096.26 EFE38045.1 - 0.0029 18.0 5.9 0.0029 18.0 5.9 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type C1_4 PF07975.12 EFE38045.1 - 0.055 13.7 0.4 0.15 12.3 0.4 1.7 1 0 0 1 1 1 0 TFIIH C1-like domain zf-C2H2_4 PF13894.6 EFE38045.1 - 1.5 9.9 18.3 0.082 13.8 4.9 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger LisH PF08513.11 EFE38050.1 - 4.9e-05 23.1 0.1 9.1e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 LisH TRAPP PF04051.16 EFE38051.1 - 4.8e-35 120.4 0.0 6.5e-35 120.0 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PNGaseA PF12222.8 EFE38051.1 - 0.0045 15.9 0.0 0.005 15.7 0.0 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A WD40 PF00400.32 EFE38052.1 - 8.4e-28 96.1 12.2 0.00018 22.2 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE38052.1 - 2.9e-10 40.3 0.0 0.0097 16.2 0.0 4.0 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE38052.1 - 0.0078 14.9 0.6 0.21 10.2 0.2 2.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFE38052.1 - 0.14 10.9 1.2 5.9 5.5 0.1 2.3 1 1 0 2 2 2 0 Nup133 N terminal like Glyco_hydro_47 PF01532.20 EFE38054.1 - 8.2e-53 179.9 0.0 1e-52 179.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DNA_pol_B_exo2 PF10108.9 EFE38054.1 - 0.0053 16.5 0.0 0.0098 15.6 0.0 1.3 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Glyco_hydro_47 PF01532.20 EFE38055.1 - 6.9e-52 176.9 0.1 9.7e-52 176.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 MiaE PF06175.11 EFE38055.1 - 0.28 10.7 0.0 0.45 10.1 0.0 1.2 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) Trypan_PARP PF05887.11 EFE38056.1 - 1.5e-08 34.7 32.8 2.8e-08 33.8 32.8 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Helicase_C PF00271.31 EFE38056.1 - 3e-08 34.0 0.0 6.3e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 EFE38056.1 - 0.0014 18.4 9.9 0.003 17.4 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SNF2_N PF00176.23 EFE38056.1 - 0.002 16.9 0.0 0.0029 16.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ERCC3_RAD25_C PF16203.5 EFE38056.1 - 0.14 11.3 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Prok-RING_4 PF14447.6 EFE38056.1 - 0.29 11.0 8.1 0.63 9.9 8.1 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFE38056.1 - 3.2 7.8 9.4 8.4 6.4 9.4 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EFE38056.1 - 3.7 7.5 11.7 14 5.7 11.7 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_2 PF07719.17 EFE38057.1 - 3.5e-08 33.0 23.7 0.0003 20.7 0.0 6.8 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFE38057.1 - 5.8e-08 32.2 7.5 0.00031 20.4 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFE38057.1 - 3.4e-07 30.0 0.5 0.22 11.8 0.0 5.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFE38057.1 - 4.5e-07 30.3 16.5 0.06 13.9 1.1 5.7 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFE38057.1 - 1.3e-05 25.5 6.5 6.1 7.7 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFE38057.1 - 1.4e-05 25.5 22.9 0.034 14.9 0.3 8.4 8 1 1 9 9 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFE38057.1 - 0.00035 21.2 0.2 0.00035 21.2 0.2 6.4 7 1 0 7 7 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFE38057.1 - 0.00099 19.4 14.6 2.6 8.4 1.8 5.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFE38057.1 - 0.0014 18.5 8.4 0.71 10.0 0.0 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE38057.1 - 0.0029 17.3 10.9 0.01 15.5 0.1 5.3 5 0 0 5 5 5 1 TPR repeat TPR_10 PF13374.6 EFE38057.1 - 1.3 9.0 10.8 9.3 6.3 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFE38057.1 - 2.2 8.9 7.5 15 6.3 0.1 5.2 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFE38057.1 - 8.3 6.6 16.0 1.6 9.0 0.1 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat Pmp3 PF01679.17 EFE38058.1 - 8.6e-19 67.5 9.5 1.2e-18 67.0 9.5 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF908 PF06012.12 EFE38058.1 - 0.97 8.8 3.4 1.2 8.4 3.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SH3_9 PF14604.6 EFE38059.1 - 8.7e-06 25.5 0.2 1.6e-05 24.6 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFE38059.1 - 0.00022 20.7 0.1 0.00041 19.9 0.1 1.4 1 0 0 1 1 1 1 SH3 domain Syndecan PF01034.20 EFE38059.1 - 0.029 14.3 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Rax2 PF12768.7 EFE38059.1 - 0.033 13.6 0.0 0.072 12.5 0.0 1.6 2 0 0 2 2 2 0 Cortical protein marker for cell polarity SKG6 PF08693.10 EFE38059.1 - 0.4 10.1 2.0 0.79 9.2 2.0 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Metallophos PF00149.28 EFE38060.1 - 2.5e-12 47.7 4.4 5.4e-12 46.6 4.4 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_18 PF00704.28 EFE38061.1 - 1.2e-58 199.3 0.1 2.5e-58 198.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 NIF PF03031.18 EFE38064.1 - 1.5e-40 138.5 0.0 2.1e-40 138.0 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Fungal_trans PF04082.18 EFE38065.1 - 2.5e-16 59.5 0.0 7e-16 58.0 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Cactin_mid PF10312.9 EFE38065.1 - 0.19 11.4 0.1 0.3 10.8 0.1 1.2 1 0 0 1 1 1 0 Conserved mid region of cactin Amino_oxidase PF01593.24 EFE38066.1 - 0.0082 15.5 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase GATA PF00320.27 EFE38067.1 - 2.4e-06 27.0 1.4 4.6e-06 26.1 1.4 1.5 1 0 0 1 1 1 1 GATA zinc finger DivIVA PF05103.13 EFE38067.1 - 9.9e-05 22.4 2.2 0.00014 21.9 2.2 1.2 1 0 0 1 1 1 1 DivIVA protein Pox_A_type_inc PF04508.12 EFE38067.1 - 0.0045 16.8 1.8 0.13 12.1 0.7 2.6 2 0 0 2 2 2 1 Viral A-type inclusion protein repeat CENP-F_N PF10481.9 EFE38067.1 - 0.0062 16.2 5.9 1.2 8.7 1.9 2.4 1 1 1 2 2 2 2 Cenp-F N-terminal domain DUF1465 PF07323.12 EFE38067.1 - 0.0075 16.1 2.6 0.27 11.1 1.2 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1465) DASH_Spc19 PF08287.11 EFE38067.1 - 0.009 15.9 6.2 0.016 15.1 6.2 1.4 1 0 0 1 1 1 1 Spc19 Med4 PF10018.9 EFE38067.1 - 0.01 15.5 1.4 0.016 14.9 1.4 1.4 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF3461 PF11944.8 EFE38067.1 - 0.031 14.4 0.0 0.047 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) HAUS-augmin3 PF14932.6 EFE38067.1 - 0.25 10.9 6.7 0.32 10.5 6.7 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Csm1_N PF18504.1 EFE38067.1 - 2.5 8.5 6.9 6.3 7.2 6.9 1.7 1 1 0 1 1 1 0 Csm1 N-terminal domain JIP_LZII PF16471.5 EFE38067.1 - 3.9 7.7 8.4 14 6.0 8.4 1.8 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF2207 PF09972.9 EFE38068.1 - 3.7e-05 22.7 1.1 0.0091 14.8 0.1 2.3 2 0 0 2 2 2 2 Predicted membrane protein (DUF2207) DUF4337 PF14235.6 EFE38068.1 - 0.095 12.8 0.6 0.17 12.0 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) CTF_NFI PF00859.18 EFE38068.1 - 0.11 12.4 0.3 0.18 11.7 0.3 1.3 1 0 0 1 1 1 0 CTF/NF-I family transcription modulation region Connexin PF00029.19 EFE38068.1 - 0.55 10.0 6.1 1.2 8.8 5.5 2.0 1 1 0 1 1 1 0 Connexin DUF2722 PF10846.8 EFE38068.1 - 1.4 7.8 8.5 1.3 7.8 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Peptidase_U4 PF03419.13 EFE38068.1 - 9.3 5.4 10.1 20 4.3 10.1 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA KilA-N PF04383.13 EFE38069.1 - 0.0084 15.9 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 KilA-N domain PTCB-BRCT PF12738.7 EFE38070.1 - 3.9e-05 23.5 0.4 0.00016 21.6 0.0 2.1 2 0 0 2 2 2 1 twin BRCT domain BRCT_2 PF16589.5 EFE38070.1 - 0.0042 17.5 0.0 0.0083 16.5 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFE38070.1 - 0.064 13.7 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Mg_trans_NIPA PF05653.14 EFE38071.1 - 4.6e-88 295.1 29.0 6.5e-88 294.7 29.0 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EFE38071.1 - 2.2e-05 24.7 6.2 2.2e-05 24.7 6.2 3.2 3 0 0 3 3 3 1 EamA-like transporter family DUF5362 PF17319.2 EFE38071.1 - 0.023 14.5 4.2 0.32 10.8 0.2 3.5 2 1 0 3 3 3 0 Family of unknown function (DUF5362) DUF1435 PF07256.12 EFE38071.1 - 0.34 11.0 2.0 0.4 10.8 0.0 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1435) Patatin PF01734.22 EFE38072.1 - 4e-15 56.5 0.0 1.2e-14 55.0 0.0 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase DUF2235 PF09994.9 EFE38073.1 - 5e-92 308.3 0.0 6.2e-92 308.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) MOSC PF03473.17 EFE38074.1 - 9.2e-35 119.5 0.0 1.4e-34 118.9 0.0 1.3 1 0 0 1 1 1 1 MOSC domain SHMT PF00464.19 EFE38075.1 - 7.6e-184 610.9 0.0 4.7e-174 578.7 0.0 2.0 2 0 0 2 2 2 2 Serine hydroxymethyltransferase YihI PF04220.12 EFE38075.1 - 1.3 8.7 6.6 3.1 7.5 6.6 1.5 1 0 0 1 1 1 0 Der GTPase activator (YihI) MFS_1 PF07690.16 EFE38077.1 - 4.7e-35 121.2 33.0 4.7e-35 121.2 33.0 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily SH PF01445.17 EFE38077.1 - 0.048 13.6 0.0 0.048 13.6 0.0 2.1 2 0 0 2 2 2 0 Viral small hydrophobic protein Ras PF00071.22 EFE38078.1 - 3.1e-40 137.4 1.0 7.6e-39 132.9 1.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFE38078.1 - 8.3e-10 38.9 0.1 2e-08 34.4 0.1 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SUIM_assoc PF16619.5 EFE38078.1 - 0.0067 16.5 1.6 0.016 15.3 1.6 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 ABC_export PF16962.5 EFE38079.1 - 0.037 12.5 0.1 0.042 12.3 0.1 1.1 1 0 0 1 1 1 0 Putative ABC exporter AMP-binding PF00501.28 EFE38080.1 - 9.7e-56 189.1 0.0 7e-34 117.1 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme ACAS_N PF16177.5 EFE38080.1 - 1.4e-15 56.9 0.1 3.2e-15 55.8 0.1 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EFE38080.1 - 8.4e-15 55.5 0.0 2.4e-14 54.1 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain zf-GRF PF06839.12 EFE38081.1 - 0.37 10.9 3.6 0.42 10.7 0.7 2.4 2 1 0 2 2 2 0 GRF zinc finger SPRY PF00622.28 EFE38082.1 - 3.6e-18 65.8 0.0 3.6e-18 65.8 0.0 1.9 2 0 0 2 2 2 1 SPRY domain TFIIA PF03153.13 EFE38082.1 - 0.001 19.2 11.3 0.001 19.2 11.3 2.3 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Pyr_redox_2 PF07992.14 EFE38083.1 - 1.4e-54 185.4 0.5 2.2e-54 184.7 0.5 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFE38083.1 - 5.1e-30 104.0 0.1 1.2e-29 102.8 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFE38083.1 - 2.8e-14 53.4 0.1 2.8e-14 53.4 0.1 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE38083.1 - 6.9e-10 38.7 1.1 7.1e-09 35.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE38083.1 - 0.021 14.0 0.0 0.058 12.5 0.0 1.6 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 EFE38083.1 - 0.071 13.0 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EFE38083.1 - 1.2 8.1 3.1 1 8.4 0.4 2.2 3 1 1 4 4 4 0 Glucose inhibited division protein A ECH_1 PF00378.20 EFE38084.1 - 1.5e-42 145.6 0.0 2e-42 145.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFE38084.1 - 7.3e-27 94.7 0.1 1.3e-26 93.9 0.1 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase tRNA-synt_2b PF00587.25 EFE38085.1 - 6.4e-33 114.2 0.0 1e-32 113.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFE38085.1 - 0.00044 20.4 0.0 0.0028 17.8 0.0 2.3 3 0 0 3 3 3 1 Anticodon binding domain Fungal_trans PF04082.18 EFE38087.1 - 2.8e-21 75.7 0.0 4.7e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidohydro_2 PF04909.14 EFE38088.1 - 1.1e-19 71.3 0.0 1.3e-19 71.0 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase MFS_1 PF07690.16 EFE38089.1 - 6.7e-28 97.6 30.8 8e-28 97.4 30.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Peptidase_C12 PF01088.21 EFE38092.1 - 5.8e-53 179.8 0.0 8.9e-53 179.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EFE38092.1 - 5.1e-08 32.7 0.1 1.4e-07 31.3 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Fungal_trans_2 PF11951.8 EFE38093.1 - 6.1e-09 35.2 1.1 1e-08 34.4 1.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ANAPC5 PF12862.7 EFE38093.1 - 0.13 12.4 0.0 24 5.1 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 4HBT_3 PF13622.6 EFE38094.1 - 0.084 13.1 0.0 0.096 12.9 0.0 1.1 1 0 0 1 1 1 0 Thioesterase-like superfamily HEAT_EZ PF13513.6 EFE38095.1 - 3.7e-29 100.7 16.0 1.4e-15 57.4 0.0 10.2 8 3 4 12 12 11 5 HEAT-like repeat HEAT PF02985.22 EFE38095.1 - 7e-23 78.7 16.5 7.2e-05 22.7 0.0 11.2 13 0 0 13 13 12 3 HEAT repeat HEAT_2 PF13646.6 EFE38095.1 - 7e-17 61.6 1.3 1.8e-05 25.1 0.0 7.5 5 3 3 8 8 7 3 HEAT repeats Cnd1 PF12717.7 EFE38095.1 - 3.7e-10 40.1 0.0 0.004 17.2 0.0 4.9 3 2 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 EFE38095.1 - 6.4e-09 35.4 5.8 0.39 9.8 0.2 5.4 5 1 0 5 5 5 3 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 EFE38095.1 - 4.6e-08 33.5 0.0 0.072 13.7 0.0 4.6 4 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EFE38095.1 - 9.3e-08 31.9 0.5 0.0048 16.5 0.2 5.7 3 3 1 4 4 4 1 CLASP N terminal Xpo1 PF08389.12 EFE38095.1 - 1.6e-05 25.0 0.0 0.00047 20.3 0.0 3.5 3 1 0 3 3 2 1 Exportin 1-like protein RIX1 PF08167.12 EFE38095.1 - 8e-05 22.5 0.9 3 7.6 0.0 5.4 5 1 1 6 6 6 1 rRNA processing/ribosome biogenesis Sec7_N PF12783.7 EFE38095.1 - 0.00017 21.5 0.3 0.0095 15.8 0.1 2.7 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Adaptin_N PF01602.20 EFE38095.1 - 0.00058 18.5 0.0 0.15 10.6 0.0 3.6 2 2 1 3 3 3 1 Adaptin N terminal region DUF3437 PF11919.8 EFE38095.1 - 0.00068 19.5 0.8 0.16 11.9 0.0 4.5 6 0 0 6 6 5 1 Domain of unknown function (DUF3437) Dopey_N PF04118.14 EFE38095.1 - 0.0011 18.2 0.1 0.054 12.6 0.0 2.5 2 0 0 2 2 2 1 Dopey, N-terminal IBN_N PF03810.19 EFE38095.1 - 0.0012 18.8 0.7 0.21 11.5 0.0 4.3 3 2 1 4 4 4 1 Importin-beta N-terminal domain Arm PF00514.23 EFE38095.1 - 0.0024 17.9 6.7 2 8.6 0.0 6.1 7 0 0 7 7 6 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EFE38095.1 - 0.0052 17.0 0.0 0.029 14.5 0.0 2.3 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 DNA_alkylation PF08713.11 EFE38095.1 - 0.12 12.1 0.0 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 DNA alkylation repair enzyme HEAT_PBS PF03130.16 EFE38095.1 - 0.56 11.0 6.7 26 5.9 0.0 5.6 7 1 0 7 7 4 0 PBS lyase HEAT-like repeat Syja_N PF02383.18 EFE38096.1 - 4.1e-89 299.1 0.0 6.3e-89 298.4 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 EFE38096.1 - 7.7e-39 132.0 0.0 1.4e-38 131.2 0.0 1.4 1 0 0 1 1 1 1 Inositol phosphatase Mg_trans_NIPA PF05653.14 EFE38097.1 - 1.3e-43 149.2 7.7 1.5e-43 149.0 7.7 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA 7TMR-DISM_7TM PF07695.11 EFE38097.1 - 0.0074 16.2 4.2 0.0097 15.8 4.2 1.1 1 0 0 1 1 1 1 7TM diverse intracellular signalling EamA PF00892.20 EFE38097.1 - 0.045 13.9 4.5 0.065 13.4 4.5 1.2 1 0 0 1 1 1 0 EamA-like transporter family TrbC PF04956.13 EFE38097.1 - 0.061 13.6 1.1 0.093 13.0 1.1 1.3 1 0 0 1 1 1 0 TrbC/VIRB2 family DUF2420 PF10336.9 EFE38098.1 - 1.6e-18 66.7 0.0 2.6e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Clat_adaptor_s PF01217.20 EFE38099.1 - 6.3e-07 29.4 1.1 9.7e-07 28.8 0.9 1.3 1 1 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.11 EFE38099.1 - 0.00084 19.7 0.5 0.0014 19.0 0.4 1.4 1 1 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) Type2_restr_D3 PF16902.5 EFE38099.1 - 0.15 12.0 0.7 0.3 11.0 0.2 1.8 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain Adap_comp_sub PF00928.21 EFE38100.1 - 1e-20 74.2 0.0 1.2e-20 74.0 0.0 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family FTR1 PF03239.14 EFE38102.1 - 8.3e-81 271.5 11.6 1e-80 271.2 11.6 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family DUF4231 PF14015.6 EFE38102.1 - 0.018 15.5 0.8 0.018 15.5 0.8 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) FtsX PF02687.21 EFE38102.1 - 0.047 14.2 1.8 0.047 14.2 1.8 3.8 2 1 0 2 2 2 0 FtsX-like permease family Rft-1 PF04506.13 EFE38102.1 - 0.28 9.9 4.8 0.076 11.8 1.1 1.8 2 0 0 2 2 2 0 Rft protein Cu-oxidase_2 PF07731.14 EFE38103.1 - 3.9e-48 162.7 8.4 8.1e-43 145.4 0.4 3.5 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 EFE38103.1 - 4.1e-42 142.9 2.3 5.8e-39 132.8 0.4 3.2 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EFE38103.1 - 1.4e-37 129.3 1.3 2.6e-33 115.4 0.5 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EFE38103.1 - 0.00018 21.5 0.0 4.5 7.5 0.0 3.4 2 1 0 2 2 2 2 Cupredoxin-like domain C1q PF00386.21 EFE38103.1 - 0.087 13.0 0.0 7.2 6.8 0.2 2.3 2 0 0 2 2 2 0 C1q domain OMPdecase PF00215.24 EFE38104.1 - 1.5e-08 34.5 0.0 1.4e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 Orotidine 5'-phosphate decarboxylase / HUMPS family Cyt-b5 PF00173.28 EFE38105.1 - 1.9e-18 66.4 0.1 1.9e-18 66.4 0.1 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EFE38105.1 - 8.5e-13 48.8 15.6 8.5e-13 48.8 15.6 1.8 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 EFE38105.1 - 0.0066 16.7 0.4 0.014 15.6 0.4 1.5 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region PMI_typeI PF01238.21 EFE38106.1 - 1.7e-122 409.2 0.1 1.8e-95 320.3 0.0 2.1 1 1 1 2 2 2 2 Phosphomannose isomerase type I AraC_binding PF02311.19 EFE38106.1 - 0.026 14.4 0.0 4.1 7.3 0.0 2.6 2 0 0 2 2 2 0 AraC-like ligand binding domain DUF1325 PF07039.11 EFE38108.1 - 1.1e-33 116.1 0.0 1.1e-33 116.1 0.0 1.9 2 0 0 2 2 2 1 SGF29 tudor-like domain LBR_tudor PF09465.10 EFE38108.1 - 0.0041 16.9 0.0 0.0078 16.0 0.0 1.4 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain Voldacs PF03517.13 EFE38108.1 - 0.27 11.3 7.3 0.66 10.1 7.3 1.6 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling DNA_pol_phi PF04931.13 EFE38108.1 - 1.9 6.5 8.8 3.8 5.5 8.8 1.5 1 0 0 1 1 1 0 DNA polymerase phi FlxA PF14282.6 EFE38108.1 - 2.3 8.3 23.4 5.9 6.9 12.2 3.0 2 0 0 2 2 2 0 FlxA-like protein NOA36 PF06524.12 EFE38108.1 - 3.3 6.9 12.6 8 5.7 12.6 1.7 1 0 0 1 1 1 0 NOA36 protein GTP_cyclohydro2 PF00925.20 EFE38109.1 - 7.2e-57 191.5 0.0 9.9e-57 191.1 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II Methyltransf_23 PF13489.6 EFE38110.1 - 1.6e-12 47.5 0.0 2.3e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38110.1 - 1.6e-09 37.7 0.0 2.8e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38110.1 - 2.3e-09 37.9 0.0 7.6e-09 36.2 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE38110.1 - 6.8e-09 36.3 0.0 3.2e-08 34.1 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38110.1 - 4.2e-08 33.8 0.0 2.7e-07 31.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE38110.1 - 0.0017 17.8 0.0 0.007 15.7 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_19 PF04672.12 EFE38110.1 - 0.039 13.4 0.0 0.058 12.9 0.0 1.2 1 0 0 1 1 1 0 S-adenosyl methyltransferase Methyltransf_24 PF13578.6 EFE38110.1 - 0.054 14.5 0.0 0.13 13.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 EFE38110.1 - 0.17 10.9 0.0 0.49 9.4 0.0 1.8 2 0 0 2 2 2 0 DREV methyltransferase Fungal_trans PF04082.18 EFE38111.1 - 5.5e-09 35.4 0.0 1.4e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.22 EFE38112.1 - 4e-43 147.8 0.0 4.7e-43 147.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ca_chan_IQ PF08763.11 EFE38112.1 - 0.007 16.5 0.0 0.052 13.7 0.0 2.3 2 0 0 2 2 2 1 Voltage gated calcium channel IQ domain Trypsin_2 PF13365.6 EFE38114.1 - 3.6e-06 28.0 0.1 1.2e-05 26.2 0.1 1.9 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S64 PF08192.11 EFE38114.1 - 0.00064 18.4 0.0 0.0059 15.2 0.0 2.0 2 0 0 2 2 2 1 Peptidase family S64 Peptidase_S32 PF05579.13 EFE38114.1 - 0.022 13.9 0.0 0.04 13.1 0.0 1.4 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Peptidase_S7 PF00949.21 EFE38114.1 - 0.029 14.2 0.0 0.062 13.1 0.0 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease DUF155 PF02582.14 EFE38116.1 - 1.5e-51 174.9 0.2 2.3e-51 174.4 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Cep57_CLD PF14073.6 EFE38117.1 - 0.15 12.1 1.1 0.26 11.3 1.1 1.3 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 DUF445 PF04286.12 EFE38119.1 - 0.016 15.0 6.7 0.03 14.1 6.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Bacteriocin_IIc PF10439.9 EFE38119.1 - 9.2 6.5 8.2 16 5.7 8.2 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Ribosomal_L7Ae PF01248.26 EFE38120.1 - 1.4e-25 88.9 0.8 1.8e-25 88.5 0.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ank_2 PF12796.7 EFE38121.1 - 2.5e-24 85.6 0.2 1.2e-12 48.2 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFE38121.1 - 2.4e-20 72.3 0.8 1.7e-09 37.8 0.0 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFE38121.1 - 2e-14 53.7 0.0 3.1e-07 30.8 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFE38121.1 - 1.5e-13 50.5 0.8 0.0011 19.3 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EFE38121.1 - 7e-12 44.4 0.7 0.00015 21.9 0.0 4.2 5 0 0 5 5 5 3 Ankyrin repeat Steroid_dh PF02544.16 EFE38123.1 - 6.2e-11 42.5 1.5 6.2e-11 42.5 1.5 2.3 2 1 1 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase Podoplanin PF05808.11 EFE38124.1 - 0.0044 17.2 4.7 0.0066 16.6 4.7 1.2 1 0 0 1 1 1 1 Podoplanin Rax2 PF12768.7 EFE38124.1 - 0.0068 15.9 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Rotamase_3 PF13616.6 EFE38125.1 - 9.4e-17 61.6 0.0 1.4e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EFE38125.1 - 7e-14 52.6 0.0 9.8e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EFE38125.1 - 2.8e-05 24.9 0.0 4.5e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain UAA PF08449.11 EFE38126.1 - 2.8e-43 148.3 14.1 8.2e-43 146.7 14.1 1.7 1 1 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 EFE38126.1 - 1.5e-07 30.9 0.2 0.0012 18.1 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 EFE38126.1 - 1.2e-05 25.5 34.3 0.0004 20.6 12.4 3.8 3 1 0 3 3 3 2 EamA-like transporter family Sen15 PF09631.10 EFE38127.1 - 2.9e-15 56.4 0.0 1.3e-14 54.3 0.0 1.8 1 1 0 1 1 1 1 Sen15 protein 4HBT_3 PF13622.6 EFE38127.1 - 0.082 13.1 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily VASt PF16016.5 EFE38128.1 - 2.5e-27 96.2 0.3 7.6e-27 94.6 0.3 1.8 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 EFE38128.1 - 2.1e-10 40.7 0.1 4.1e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EFE38128.1 - 1.3e-07 32.0 0.0 5e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 PH domain GRAM PF02893.20 EFE38128.1 - 0.001 18.9 0.0 0.0022 17.8 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Kri1 PF05178.12 EFE38129.1 - 8.9e-30 103.3 21.1 8.9e-30 103.3 21.1 5.9 6 1 0 6 6 6 1 KRI1-like family Kri1_C PF12936.7 EFE38129.1 - 3.5e-29 100.8 0.2 3.5e-29 100.8 0.2 4.2 3 2 2 5 5 5 1 KRI1-like family C-terminal Mito_carr PF00153.27 EFE38130.1 - 1e-66 220.9 6.0 1.3e-24 85.9 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Stb3 PF10330.9 EFE38133.1 - 1.2e-37 127.8 0.0 2.3e-37 126.9 0.0 1.5 1 0 0 1 1 1 1 Putative Sin3 binding protein TMEM239 PF15841.5 EFE38133.1 - 0.09 12.7 0.1 0.24 11.3 0.1 1.7 1 0 0 1 1 1 0 Transmembrane protein 239 family ETRAMP PF09716.10 EFE38133.1 - 0.21 11.7 1.4 0.36 10.9 0.0 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) p450 PF00067.22 EFE38134.1 - 5.3e-43 147.4 0.0 7.7e-41 140.3 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 RdDM_RDM1 PF09187.10 EFE38135.1 - 0.13 12.3 0.0 6.4 6.9 0.0 2.0 1 1 1 2 2 2 0 RNA-directed DNA methylation 1 APH PF01636.23 EFE38136.1 - 3.3e-14 53.4 0.0 3e-13 50.3 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE38136.1 - 0.13 11.1 0.1 0.35 9.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) PTS_2-RNA PF01885.16 EFE38137.1 - 7.6e-47 159.7 0.0 9.1e-47 159.4 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Rad4 PF03835.15 EFE38138.1 - 1.8e-37 128.3 0.0 3.3e-37 127.4 0.0 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EFE38138.1 - 1.4e-28 99.1 0.1 4.5e-28 97.5 0.0 1.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EFE38138.1 - 8.2e-20 70.4 0.1 1.9e-19 69.2 0.1 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EFE38138.1 - 4.5e-16 59.5 2.9 5.9e-16 59.2 0.8 2.3 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EFE38138.1 - 0.0052 17.2 0.0 0.017 15.5 0.0 2.0 2 0 0 2 2 2 1 Transglutaminase-like superfamily SapC PF07277.11 EFE38138.1 - 0.067 12.8 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 SapC CENP-F_leu_zip PF10473.9 EFE38140.1 - 3.6e-05 23.8 22.6 3.6e-05 23.8 22.6 9.3 2 1 7 10 10 10 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 EFE38140.1 - 0.00048 19.8 159.0 0.14 11.8 35.4 5.3 1 1 3 4 4 4 3 Intermediate filament protein TACC_C PF05010.14 EFE38140.1 - 0.0043 16.9 20.2 0.0043 16.9 20.2 7.5 1 1 6 7 7 7 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Csm1_N PF18504.1 EFE38140.1 - 0.0051 17.1 6.1 0.0051 17.1 6.1 16.6 6 3 10 17 17 17 3 Csm1 N-terminal domain ERM PF00769.19 EFE38140.1 - 0.0066 16.3 26.5 0.0066 16.3 26.5 6.5 2 1 3 5 5 5 1 Ezrin/radixin/moesin family DUF4200 PF13863.6 EFE38140.1 - 0.0092 16.4 16.1 0.0092 16.4 16.1 10.1 1 1 10 11 11 11 2 Domain of unknown function (DUF4200) Pox_A_type_inc PF04508.12 EFE38140.1 - 0.053 13.4 0.2 0.053 13.4 0.2 8.7 10 0 0 10 10 10 0 Viral A-type inclusion protein repeat FAM184 PF15665.5 EFE38140.1 - 0.56 9.9 184.3 0.29 10.9 43.4 7.5 1 1 7 8 8 8 0 Family with sequence similarity 184, A and B DUF3287 PF11690.8 EFE38140.1 - 2.5 7.8 7.3 0.66 9.7 0.2 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF3287) DUF3584 PF12128.8 EFE38140.1 - 5.5 4.4 182.3 0.0077 13.8 42.3 5.3 1 1 4 5 5 5 0 Protein of unknown function (DUF3584) PTPA PF03095.15 EFE38142.1 - 2.6e-114 381.7 0.0 3.1e-114 381.5 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF572 PF04502.13 EFE38143.1 - 1.1e-60 206.0 4.2 1.3e-60 205.8 4.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) OSR1_C PF12202.8 EFE38143.1 - 0.072 13.3 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain Glyco_hydro_3_C PF01915.22 EFE38144.1 - 2.6e-48 164.7 0.0 4e-48 164.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EFE38144.1 - 8.2e-19 67.5 0.1 1.5e-18 66.6 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF3143 PF11341.8 EFE38144.1 - 0.08 13.3 0.8 18 5.8 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3143) Glyco_hydro_3 PF00933.21 EFE38145.1 - 8.4e-29 100.9 0.0 1.1e-28 100.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain PNP_UDP_1 PF01048.20 EFE38146.1 - 1.3e-38 132.6 0.0 1.7e-38 132.2 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily BUD22 PF09073.10 EFE38147.1 - 2.1e-101 340.4 19.8 2.8e-101 340.0 19.8 1.1 1 0 0 1 1 1 1 BUD22 SIS PF01380.22 EFE38148.1 - 3.3e-12 46.4 0.0 1.4e-11 44.4 0.0 2.0 1 1 0 1 1 1 1 SIS domain SIS_2 PF13580.6 EFE38148.1 - 3.9e-05 23.7 0.0 7.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 SIS domain BATS PF06968.13 EFE38148.1 - 0.027 14.6 0.0 0.15 12.3 0.0 2.1 2 0 0 2 2 2 0 Biotin and Thiamin Synthesis associated domain CheX PF13690.6 EFE38148.1 - 0.15 12.2 1.7 11 6.3 0.1 3.0 3 0 0 3 3 3 0 Chemotaxis phosphatase CheX Ubie_methyltran PF01209.18 EFE38149.1 - 4.4e-78 261.8 0.0 7e-78 261.2 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EFE38149.1 - 1.2e-15 57.9 0.0 2.2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE38149.1 - 2.3e-14 53.8 0.0 4.7e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38149.1 - 3.8e-12 46.2 0.0 4.9e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38149.1 - 3.4e-10 40.5 0.0 5.3e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE38149.1 - 1.7e-06 27.9 0.0 2.6e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EFE38149.1 - 0.057 13.3 0.0 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 Hypothetical methyltransferase E1_dh PF00676.20 EFE38150.1 - 5.6e-91 304.6 0.2 6.6e-91 304.4 0.2 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EFE38150.1 - 0.00042 20.1 0.2 0.0017 18.2 0.2 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EFE38150.1 - 0.018 14.3 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase XFP_N PF09364.10 EFE38150.1 - 0.044 12.6 0.0 0.13 11.0 0.0 1.7 2 0 0 2 2 2 0 XFP N-terminal domain RRM_1 PF00076.22 EFE38152.1 - 9.6e-05 22.1 0.0 0.00028 20.6 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_4 PF14570.6 EFE38152.1 - 0.02 14.7 0.1 0.034 13.9 0.1 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Cyclin PF08613.11 EFE38153.1 - 1.5e-12 48.2 1.8 4.6e-12 46.6 1.8 1.9 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EFE38153.1 - 0.0071 16.1 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain YihI PF04220.12 EFE38154.1 - 1.4 8.6 7.0 2 8.2 7.0 1.3 1 0 0 1 1 1 0 Der GTPase activator (YihI) GHMP_kinases_N PF00288.26 EFE38155.1 - 2.5e-11 43.6 0.1 6.4e-11 42.3 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFE38155.1 - 0.00013 22.3 0.0 0.00027 21.2 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Med5 PF08689.10 EFE38156.1 - 4.8e-113 379.0 0.0 1.6e-75 254.8 0.0 3.6 2 2 1 3 3 3 3 Mediator complex subunit Med5 Glutaredoxin2_C PF04399.13 EFE38156.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Tyr-DNA_phospho PF06087.12 EFE38158.1 - 2.8e-44 151.7 0.1 3.9e-44 151.2 0.1 1.2 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase UIM PF02809.20 EFE38158.1 - 0.052 13.5 1.0 0.052 13.5 1.0 3.3 3 0 0 3 3 3 0 Ubiquitin interaction motif BON PF04972.17 EFE38158.1 - 0.45 10.9 2.6 8.9 6.7 1.1 2.9 2 1 1 3 3 3 0 BON domain NAD_binding_8 PF13450.6 EFE38159.1 - 6.2e-15 55.2 0.3 6.7e-14 51.9 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFE38159.1 - 2.3e-09 37.3 0.0 1.6e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFE38159.1 - 1.5e-08 34.2 0.1 2.2e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFE38159.1 - 9.1e-08 31.8 0.0 6.6e-06 25.7 0.0 2.7 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EFE38159.1 - 3.5e-06 26.4 0.1 6.6e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFE38159.1 - 6.5e-06 25.1 0.4 7.5e-05 21.6 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EFE38159.1 - 3.5e-05 23.2 0.0 7e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EFE38159.1 - 4.6e-05 23.9 0.2 0.25 11.9 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFE38159.1 - 0.00047 19.6 0.0 0.0027 17.1 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFE38159.1 - 0.0015 17.8 0.1 0.059 12.6 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFE38159.1 - 0.0017 18.4 1.2 0.022 14.8 0.0 2.8 4 0 0 4 4 3 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EFE38159.1 - 0.0046 15.9 0.6 0.011 14.7 0.0 1.9 3 0 0 3 3 3 1 Tryptophan halogenase Lycopene_cycl PF05834.12 EFE38159.1 - 0.019 14.0 0.1 0.029 13.4 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 EFE38159.1 - 0.025 13.8 0.0 0.11 11.8 0.1 2.0 2 1 0 2 2 2 0 FAD binding domain GIDA PF01134.22 EFE38159.1 - 0.04 13.0 0.1 0.071 12.2 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A CAP_assoc_N PF14504.6 EFE38159.1 - 0.082 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 CAP-associated N-terminal ApbA PF02558.16 EFE38159.1 - 0.16 11.6 0.0 0.63 9.7 0.0 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA GMC_oxred_N PF00732.19 EFE38159.1 - 0.2 11.0 0.0 15 4.9 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase AlaDh_PNT_C PF01262.21 EFE38159.1 - 0.2 10.9 0.0 0.45 9.8 0.0 1.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 EFE38160.1 - 1.2e-31 109.7 0.0 1.7e-31 109.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE38160.1 - 4.8e-23 81.9 0.0 6.3e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE38160.1 - 4.2e-08 33.3 0.0 6.2e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFE38160.1 - 4.2e-06 26.4 0.0 1.4e-05 24.7 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFE38160.1 - 0.0012 18.8 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EFE38160.1 - 0.0016 17.6 0.0 0.0024 17.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EFE38160.1 - 0.0023 17.1 0.0 0.0029 16.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EFE38160.1 - 0.029 13.9 0.0 0.069 12.7 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family 3Beta_HSD PF01073.19 EFE38160.1 - 0.23 10.5 0.0 0.3 10.0 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Sec1 PF00995.23 EFE38161.1 - 2.3e-127 426.7 0.0 2.8e-127 426.4 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF3605 PF12239.8 EFE38162.1 - 5.4e-50 169.7 2.5 6.8e-50 169.4 2.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Phytochelatin_C PF09328.10 EFE38162.1 - 0.06 12.7 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) GIDA PF01134.22 EFE38163.1 - 2.7e-127 425.1 0.0 5.2e-127 424.2 0.0 1.4 2 0 0 2 2 2 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EFE38163.1 - 1.1e-65 221.7 0.0 1.5e-65 221.3 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain ARD PF03079.14 EFE38164.1 - 7.8e-48 162.6 0.1 9.1e-48 162.4 0.1 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EFE38164.1 - 5.9e-09 35.5 0.0 9.5e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EFE38164.1 - 4.4e-05 23.4 0.0 6.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 EFE38164.1 - 0.036 13.7 0.0 0.05 13.2 0.0 1.2 1 0 0 1 1 1 0 Cupin MMM1 PF10296.9 EFE38165.1 - 1.8e-134 448.0 0.0 2.2e-134 447.7 0.0 1.0 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 SARAF PF06682.12 EFE38166.1 - 1.3e-85 288.0 7.1 2.6e-84 283.7 7.1 2.0 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Myb_DNA-bind_7 PF15963.5 EFE38167.1 - 5.2e-28 96.8 0.1 5.2e-28 96.8 0.1 2.4 2 1 1 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EFE38167.1 - 0.00016 21.8 0.7 0.00063 19.9 0.0 2.3 3 0 0 3 3 3 1 Myb-like DNA-binding domain Maf PF02545.14 EFE38167.1 - 0.008 16.0 0.6 0.015 15.2 0.6 1.3 1 0 0 1 1 1 1 Maf-like protein FTZ PF03867.14 EFE38167.1 - 0.75 9.3 4.1 1.5 8.3 4.1 1.5 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region BRE1 PF08647.11 EFE38168.1 - 5.1e-25 87.4 15.8 5.1e-25 87.4 15.8 6.8 4 2 3 7 7 7 2 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 EFE38168.1 - 5.3e-10 39.0 8.1 9.7e-10 38.2 8.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFE38168.1 - 2.7e-09 36.7 8.5 5.3e-09 35.8 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE38168.1 - 1e-07 31.7 10.8 1.9e-07 30.9 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE38168.1 - 1.1e-07 31.7 6.4 2.2e-07 30.7 6.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFE38168.1 - 1.2e-07 32.0 9.1 2.1e-07 31.1 9.1 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EFE38168.1 - 2.3e-07 30.6 8.5 4.2e-07 29.7 8.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFE38168.1 - 2.2e-06 27.5 11.2 4e-06 26.7 11.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain DUF745 PF05335.13 EFE38168.1 - 0.00071 19.3 6.4 0.00071 19.3 6.4 5.5 3 2 3 6 6 5 1 Protein of unknown function (DUF745) zf-rbx1 PF12678.7 EFE38168.1 - 0.0016 18.7 5.1 0.0048 17.2 5.1 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EFE38168.1 - 0.0018 18.4 7.0 0.0035 17.5 7.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING DUF1272 PF06906.11 EFE38168.1 - 0.018 15.1 5.9 0.038 14.1 5.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_10 PF16685.5 EFE38168.1 - 0.034 14.3 7.1 0.082 13.1 7.1 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 EFE38168.1 - 0.068 13.0 7.7 0.55 10.1 8.4 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 EFE38168.1 - 0.57 10.3 4.5 1.8 8.7 4.5 1.9 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-Nse PF11789.8 EFE38168.1 - 0.58 10.0 6.0 1.4 8.8 6.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 EFE38168.1 - 1 9.3 3.8 2.1 8.3 3.8 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DZR PF12773.7 EFE38168.1 - 1.3 9.1 6.5 2.9 8.0 6.5 1.5 1 0 0 1 1 1 0 Double zinc ribbon DUF1192 PF06698.11 EFE38168.1 - 1.6 8.8 13.9 0.64 10.1 0.3 5.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) FYVE PF01363.21 EFE38168.1 - 1.8 8.8 12.8 34 4.7 12.0 2.6 1 1 1 2 2 2 0 FYVE zinc finger HALZ PF02183.18 EFE38168.1 - 2.7 8.3 30.3 5.9 7.2 0.3 6.6 6 0 0 6 6 6 0 Homeobox associated leucine zipper UreF PF01730.16 EFE38169.1 - 4.3e-23 82.3 1.7 5.6e-23 82.0 1.7 1.2 1 0 0 1 1 1 1 UreF ABC1 PF03109.16 EFE38170.1 - 3.6e-33 114.3 0.0 8.7e-33 113.0 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Mannosyl_trans3 PF11051.8 EFE38171.1 - 9.5e-59 199.0 0.0 4.7e-33 114.7 0.0 2.2 1 1 1 2 2 2 2 Mannosyltransferase putative Glyco_transf_8 PF01501.20 EFE38171.1 - 0.032 13.8 0.1 0.12 11.9 0.0 1.8 1 1 0 2 2 2 0 Glycosyl transferase family 8 AMPK1_CBM PF16561.5 EFE38172.1 - 2.2e-30 104.7 0.1 3.8e-30 103.9 0.1 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase PDEase_II PF02112.15 EFE38175.1 - 3.3e-55 187.5 0.0 1.7e-45 155.6 0.0 3.0 2 1 0 2 2 2 2 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 EFE38175.1 - 0.0012 18.4 0.0 0.0024 17.4 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFE38175.1 - 0.0026 17.8 0.1 0.0066 16.5 0.1 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Fungal_trans PF04082.18 EFE38176.1 - 0.011 14.7 1.0 0.047 12.7 0.3 2.2 1 1 1 2 2 2 0 Fungal specific transcription factor domain adh_short PF00106.25 EFE38177.1 - 9e-18 64.4 0.0 1e-15 57.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFE38177.1 - 5.9e-10 39.1 0.0 1.8e-07 31.0 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE38177.1 - 6e-08 32.8 0.0 1.3e-07 31.7 0.0 1.6 2 0 0 2 2 2 1 KR domain ALO PF04030.14 EFE38178.1 - 3.3e-91 305.7 0.1 5.2e-91 305.0 0.1 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EFE38178.1 - 2e-31 108.6 0.1 3.2e-31 107.9 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DUF4045 PF13254.6 EFE38179.1 - 1.2e-93 315.1 45.2 1.2e-93 315.1 45.2 6.3 3 3 1 4 4 4 1 Domain of unknown function (DUF4045) Gelsolin PF00626.22 EFE38179.1 - 1.1e-10 41.2 0.0 0.0041 17.0 0.0 3.8 3 0 0 3 3 3 3 Gelsolin repeat Acetyltransf_1 PF00583.25 EFE38180.1 - 0.081 13.2 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFE38180.1 - 0.17 12.3 0.0 0.41 11.1 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DEAD PF00270.29 EFE38181.1 - 5.5e-46 156.5 0.0 1.1e-45 155.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE38181.1 - 2e-29 102.2 0.2 2.2e-27 95.6 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UTP25 PF06862.12 EFE38181.1 - 0.0092 14.8 2.2 0.022 13.5 0.3 2.4 2 1 1 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 HMGL-like PF00682.19 EFE38182.1 - 1.7e-69 234.3 0.0 2.8e-69 233.6 0.0 1.4 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 EFE38182.1 - 5e-21 75.0 0.0 9.8e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain AMP-binding PF00501.28 EFE38183.1 - 9.6e-65 218.8 0.1 1.3e-36 126.2 0.0 4.7 2 2 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 EFE38183.1 - 1e-09 39.2 0.0 3.1e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 DMAP1-binding Domain GvpG PF05120.12 EFE38183.1 - 0.0073 16.3 0.2 0.017 15.1 0.2 1.6 1 0 0 1 1 1 1 Gas vesicle protein G Carb_anhydrase PF00194.21 EFE38184.1 - 6.5e-35 120.9 0.1 1.2e-34 120.0 0.1 1.4 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase CA_like PF10563.9 EFE38184.1 - 0.35 10.8 2.8 0.51 10.2 0.3 2.5 2 1 1 3 3 3 0 Putative carbonic anhydrase RNR_inhib PF08591.10 EFE38185.1 - 2.4e-26 93.1 0.6 6.5e-26 91.7 0.1 2.0 2 0 0 2 2 2 1 Ribonucleotide reductase inhibitor SDA1 PF05285.12 EFE38186.1 - 1.1e-89 301.3 55.5 2.3e-89 300.2 48.8 2.8 2 1 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 EFE38186.1 - 3.1e-23 81.8 0.0 8.7e-23 80.4 0.0 1.8 1 0 0 1 1 1 1 NUC130/3NT domain Ribosomal_S7 PF00177.21 EFE38187.1 - 4.2e-37 127.1 1.7 5.2e-37 126.8 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e p450 PF00067.22 EFE38189.1 - 2e-50 171.9 0.0 8.3e-50 169.9 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 EFE38190.1 - 1.7e-16 60.4 0.0 1.2e-09 38.0 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38190.1 - 1.8e-06 27.5 0.1 0.016 14.5 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.14 EFE38190.1 - 0.065 12.6 0.1 0.18 11.1 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Metallophos PF00149.28 EFE38192.1 - 4e-11 43.8 1.3 6.8e-11 43.0 1.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EFE38192.1 - 0.0023 18.2 0.0 0.0062 16.8 0.0 1.7 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain DmpG_comm PF07836.11 EFE38192.1 - 0.097 12.2 0.0 0.76 9.4 0.0 2.2 2 0 0 2 2 2 0 DmpG-like communication domain Pkinase PF00069.25 EFE38193.1 - 4.4e-10 39.4 0.0 3.1e-09 36.6 0.0 2.4 2 2 1 3 3 3 1 Protein kinase domain 4HBT_3 PF13622.6 EFE38194.1 - 2.7e-60 204.7 0.3 3.4e-60 204.4 0.3 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EFE38194.1 - 5.7e-21 74.7 0.0 1.9e-10 40.7 0.0 3.1 3 0 0 3 3 3 3 Acyl-CoA thioesterase DUF3445 PF11927.8 EFE38195.1 - 1.9e-62 210.8 0.0 2.5e-62 210.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Lipase_GDSL_3 PF14606.6 EFE38195.1 - 0.17 12.0 0.0 0.37 10.9 0.0 1.5 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family DUF1917 PF08939.10 EFE38195.1 - 0.18 11.6 1.3 3.3 7.5 1.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1917) HSP70 PF00012.20 EFE38196.1 - 3.5e-10 38.7 0.1 7.3e-09 34.4 0.1 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EFE38196.1 - 0.14 11.0 0.0 0.38 9.5 0.0 1.6 2 0 0 2 2 2 0 MreB/Mbl protein ANAPC10 PF03256.16 EFE38197.1 - 4e-45 153.7 0.0 6.1e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) BUD22 PF09073.10 EFE38197.1 - 1.4 8.2 28.0 1.9 7.8 13.8 2.1 2 0 0 2 2 2 0 BUD22 CPSF100_C PF13299.6 EFE38197.1 - 2.4 8.3 9.2 4.4 7.4 4.3 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FYDLN_acid PF09538.10 EFE38197.1 - 2.5 8.8 27.7 0.95 10.2 5.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF3306 PF11748.8 EFE38197.1 - 3.3 8.6 10.8 1.2 10.0 3.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) NARP1 PF12569.8 EFE38197.1 - 3.6 6.4 10.5 0.28 10.1 0.1 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 SpoIIIAH PF12685.7 EFE38197.1 - 7.4 6.3 11.6 17 5.1 5.9 2.1 2 0 0 2 2 2 0 SpoIIIAH-like protein Iso_dh PF00180.20 EFE38198.1 - 1.3e-125 419.2 0.0 1.4e-125 419.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AAA_lid_3 PF17862.1 EFE38198.1 - 0.041 13.7 0.0 0.12 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA+ lid domain TMEM208_SND2 PF05620.11 EFE38199.1 - 1.8e-51 174.2 0.0 2.3e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF4843 PF16132.5 EFE38200.1 - 0.046 13.3 0.0 0.16 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4843) PET10 PF17316.2 EFE38200.1 - 0.48 9.9 6.1 3.6 7.0 0.2 2.6 1 1 1 2 2 2 0 Petite colonies protein 10 dCache_2 PF08269.11 EFE38200.1 - 0.75 8.9 5.2 0.17 11.0 0.9 2.0 2 0 0 2 2 2 0 Cache domain Prominin PF05478.11 EFE38200.1 - 0.78 7.6 3.2 0.77 7.6 1.6 1.8 2 0 0 2 2 2 0 Prominin RINGv PF12906.7 EFE38201.1 - 5.3e-16 58.5 10.1 9.4e-16 57.7 10.1 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EFE38201.1 - 0.0037 17.6 8.8 0.0066 16.8 8.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EFE38201.1 - 0.41 10.7 3.6 0.92 9.6 3.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 EFE38201.1 - 0.95 9.6 3.7 2 8.6 3.7 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger zf-RING_4 PF14570.6 EFE38201.1 - 1.4 8.8 6.6 2.3 8.1 6.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4611 PF15387.6 EFE38201.1 - 1.4 9.2 10.4 6.3 7.1 10.4 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) zf-C3HC4_3 PF13920.6 EFE38201.1 - 3.4 7.6 5.6 6.7 6.7 5.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EFE38201.1 - 4.1 7.6 6.7 9.1 6.5 6.7 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain Merozoite_SPAM PF07133.11 EFE38201.1 - 7 6.6 20.3 14 5.6 20.3 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nop14 PF04147.12 EFE38201.1 - 10 4.2 9.9 18 3.3 9.9 1.3 1 0 0 1 1 1 0 Nop14-like family HeLo PF14479.6 EFE38202.1 - 0.00019 21.3 0.3 0.0045 16.9 0.3 2.3 1 1 0 1 1 1 1 Prion-inhibition and propagation Trypsin_2 PF13365.6 EFE38202.1 - 0.13 13.2 0.1 0.27 12.1 0.1 1.5 1 0 0 1 1 1 0 Trypsin-like peptidase domain ACC_central PF08326.12 EFE38203.1 - 6.5e-284 943.7 0.0 8e-284 943.4 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EFE38203.1 - 2.7e-190 633.2 0.0 5.4e-190 632.2 0.0 1.5 2 0 0 2 2 2 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EFE38203.1 - 1.3e-53 181.7 0.0 2.4e-53 180.8 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EFE38203.1 - 6.9e-23 80.8 0.0 9.1e-20 70.8 0.0 3.0 2 0 0 2 2 2 2 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EFE38203.1 - 8.1e-16 57.6 0.2 2.3e-15 56.2 0.0 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EFE38203.1 - 8.9e-05 22.1 0.0 0.00029 20.4 0.0 1.9 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EFE38203.1 - 0.0002 21.4 0.0 0.00045 20.3 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_carb_N PF00289.22 EFE38203.1 - 0.025 15.1 0.0 0.051 14.1 0.0 1.6 1 0 0 1 1 1 0 Biotin carboxylase, N-terminal domain ATP-grasp PF02222.22 EFE38203.1 - 0.028 14.0 0.0 0.067 12.8 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Antiterm PF03589.13 EFE38203.1 - 0.053 13.8 0.1 0.76 10.2 0.0 2.7 3 0 0 3 3 2 0 Antitermination protein ATPgrasp_Ter PF15632.6 EFE38203.1 - 0.1 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_carb_N PF00289.22 EFE38204.1 - 1.9e-08 34.8 0.1 2.9e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain NUDE_C PF04880.13 EFE38205.1 - 5.4e-57 193.1 11.1 5.4e-57 193.1 11.1 4.1 4 0 0 4 4 3 1 NUDE protein, C-terminal conserved region DUF16 PF01519.16 EFE38205.1 - 0.011 16.2 5.2 0.011 16.2 5.2 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 CLZ PF16526.5 EFE38205.1 - 0.014 15.7 3.5 0.014 15.7 3.5 3.4 4 1 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1729 PF08354.10 EFE38205.1 - 0.038 12.9 0.6 0.056 12.3 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) DMPK_coil PF08826.10 EFE38205.1 - 0.039 14.0 1.3 0.039 14.0 1.3 4.6 3 2 2 5 5 5 0 DMPK coiled coil domain like LPP PF04728.13 EFE38205.1 - 0.083 13.3 0.3 2.4 8.6 0.0 3.1 3 1 0 3 3 3 0 Lipoprotein leucine-zipper PSII_Pbs27 PF13326.6 EFE38205.1 - 0.11 12.8 2.8 0.23 11.8 2.8 1.5 1 0 0 1 1 1 0 Photosystem II Pbs27 ZapB PF06005.12 EFE38205.1 - 0.33 11.4 33.7 0.23 11.9 8.0 4.8 2 1 2 4 4 4 0 Cell division protein ZapB ADIP PF11559.8 EFE38205.1 - 1.7 8.7 25.8 4.1 7.5 4.6 3.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 EFE38205.1 - 1.7 9.1 26.7 1.3 9.5 14.1 2.7 2 1 1 3 3 3 0 Fez1 DUF812 PF05667.11 EFE38205.1 - 1.7 7.4 24.3 3.2 6.5 24.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) GAS PF13851.6 EFE38205.1 - 6.9 6.0 27.6 3.5 6.9 13.8 2.4 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Hexokinase_1 PF00349.21 EFE38206.1 - 1.2e-49 168.9 0.0 1.7e-49 168.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EFE38206.1 - 9.8e-41 139.7 0.0 1.6e-40 139.1 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Isochorismatase PF00857.20 EFE38207.1 - 5.4e-38 130.9 0.0 3e-37 128.5 0.0 1.9 2 0 0 2 2 2 1 Isochorismatase family FAR1 PF03101.15 EFE38207.1 - 6.5e-06 26.8 0.1 1.6e-05 25.5 0.0 1.6 2 0 0 2 2 2 1 FAR1 DNA-binding domain AFT PF08731.11 EFE38207.1 - 0.058 13.8 0.0 0.094 13.1 0.0 1.3 1 0 0 1 1 1 0 Transcription factor AFT DUF2040 PF09745.9 EFE38208.1 - 9.1e-39 132.3 14.6 9.1e-39 132.3 14.6 3.9 3 1 0 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) Adhesin_P1_N PF18652.1 EFE38208.1 - 5.8 7.0 18.2 13 5.9 4.9 3.2 2 0 0 2 2 2 0 Adhesin P1 N-terminal domain Zip PF02535.22 EFE38209.1 - 4.7e-17 62.2 9.2 8.1e-16 58.1 9.0 2.3 1 1 0 1 1 1 1 ZIP Zinc transporter Stomagen PF16851.5 EFE38209.1 - 0.18 11.8 0.4 0.39 10.7 0.4 1.5 1 0 0 1 1 1 0 Stomagen Endonuclease_NS PF01223.23 EFE38210.1 - 3.5e-65 220.0 0.0 4.4e-65 219.7 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sec7 PF01369.20 EFE38212.1 - 1.3e-31 109.7 0.1 2e-31 109.1 0.1 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EFE38212.1 - 2.5e-06 27.8 0.0 6.1e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EFE38212.1 - 1.2e-05 25.8 0.1 4.1e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 PH domain zf-RING_UBOX PF13445.6 EFE38213.1 - 5.1e-06 26.4 8.2 1.4e-05 25.0 1.2 3.1 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFE38213.1 - 5e-05 23.0 9.2 0.00019 21.2 1.5 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE38213.1 - 0.00012 22.0 4.4 0.00012 22.0 4.4 2.7 2 1 0 2 2 2 1 zinc-RING finger domain zf-NOSIP PF15906.5 EFE38213.1 - 0.00013 22.0 0.0 0.00025 21.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_2 PF13639.6 EFE38213.1 - 0.00015 22.0 11.0 0.0081 16.5 4.9 3.1 2 1 1 3 3 3 2 Ring finger domain Atg14 PF10186.9 EFE38213.1 - 0.0003 20.0 7.9 0.0003 20.0 7.9 1.6 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 Rtf2 PF04641.12 EFE38213.1 - 0.0005 19.5 1.8 0.0005 19.5 1.8 3.3 2 1 1 3 3 2 2 Rtf2 RING-finger zf-C3HC4_3 PF13920.6 EFE38213.1 - 0.00092 19.0 13.0 0.0016 18.2 1.9 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 EFE38213.1 - 0.0037 17.1 0.8 0.01 15.7 0.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EFE38213.1 - 0.0045 17.1 13.6 0.02 15.0 5.8 3.6 2 2 1 3 3 3 1 FYVE zinc finger zf-C3HC4 PF00097.25 EFE38213.1 - 0.0045 16.8 1.3 0.0045 16.8 1.3 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF1195 PF06708.11 EFE38213.1 - 0.014 15.2 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) Prok-RING_4 PF14447.6 EFE38213.1 - 0.094 12.6 14.3 0.048 13.5 5.8 3.5 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-FLZ PF04570.14 EFE38213.1 - 0.64 9.5 4.0 3.5 7.2 0.1 3.3 3 0 0 3 3 3 0 zinc-finger of the FCS-type, C2-C2 Siva PF05458.12 EFE38213.1 - 0.74 9.5 6.6 0.24 11.1 1.1 2.2 2 0 0 2 2 2 0 Cd27 binding protein (Siva) IBR PF01485.21 EFE38213.1 - 1.4 9.2 12.9 1.2 9.4 2.3 3.4 2 1 0 3 3 3 0 IBR domain, a half RING-finger domain zf-C3HC4_4 PF15227.6 EFE38213.1 - 1.6 9.0 13.6 0.93 9.7 6.3 3.4 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING CDC45 PF02724.14 EFE38213.1 - 2.2 6.4 11.9 3 6.0 11.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Zn_ribbon_17 PF17120.5 EFE38213.1 - 3.9 7.2 9.2 5 6.8 0.3 2.7 3 0 0 3 3 2 0 Zinc-ribbon, C4HC2 type SET PF00856.28 EFE38214.1 - 4.7e-14 53.1 0.1 6.9e-13 49.3 0.1 2.2 1 1 0 1 1 1 1 SET domain SAF PF08666.12 EFE38214.1 - 0.04 14.5 0.0 12 6.6 0.0 2.3 2 0 0 2 2 2 0 SAF domain Peptidase_M14 PF00246.24 EFE38215.1 - 2.9e-73 247.2 0.0 3.8e-73 246.8 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EFE38215.1 - 0.13 12.6 0.1 0.3 11.5 0.1 1.6 1 0 0 1 1 1 0 Carboxypeptidase activation peptide NicO PF03824.16 EFE38216.1 - 2.2e-36 125.7 12.2 1.5e-32 113.1 0.9 2.5 2 1 0 2 2 2 2 High-affinity nickel-transport protein Peptidase_S8 PF00082.22 EFE38217.1 - 7.3e-34 117.4 14.5 1.3e-33 116.5 14.5 1.4 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE38217.1 - 6.6e-18 65.2 0.2 1.1e-17 64.5 0.2 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 DNA_pol_B_thumb PF14791.6 EFE38218.1 - 3e-22 78.6 0.6 1.5e-21 76.3 0.2 2.4 3 0 0 3 3 3 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 EFE38218.1 - 1.8e-18 66.8 0.0 3.2e-16 59.5 0.0 2.5 2 0 0 2 2 2 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 EFE38218.1 - 7.7e-18 64.1 0.7 1.6e-17 63.0 0.7 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 EFE38218.1 - 1.1e-09 38.5 0.0 3.3e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 EFE38218.1 - 0.0054 17.0 0.1 0.014 15.7 0.1 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH_5 PF14520.6 EFE38218.1 - 0.03 14.9 0.0 0.11 13.1 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix domain DUF993 PF06187.11 EFE38218.1 - 0.046 12.6 0.0 0.073 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF993) BRCT_2 PF16589.5 EFE38218.1 - 0.099 13.1 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain PhoLip_ATPase_C PF16212.5 EFE38219.1 - 8.5e-83 277.9 18.4 8.5e-83 277.9 18.4 2.5 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFE38219.1 - 1e-26 92.4 8.1 4.2e-26 90.4 8.1 2.1 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFE38219.1 - 1e-12 47.9 0.0 1.8e-11 44.0 0.0 2.8 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFE38219.1 - 3.6e-12 47.0 0.7 1.1e-07 32.4 0.0 3.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFE38219.1 - 3e-07 30.1 0.0 8.4e-07 28.7 0.0 1.7 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFE38219.1 - 0.0018 18.0 0.3 0.01 15.6 0.3 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase RNase_PH PF01138.21 EFE38220.1 - 7.1e-19 68.6 0.0 1.5e-18 67.6 0.0 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFE38220.1 - 2.3e-08 33.9 0.2 8.4e-08 32.1 0.1 2.0 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 WD40 PF00400.32 EFE38221.1 - 1.4e-30 104.9 29.0 2.8e-07 31.1 1.9 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE38221.1 - 1.4e-16 60.6 0.1 0.0001 22.5 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EFE38221.1 - 0.033 12.5 0.0 0.13 10.6 0.0 1.8 1 1 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Ytp1 PF10355.9 EFE38222.1 - 1.4e-84 283.6 21.3 5.7e-59 199.6 6.8 2.6 2 2 1 3 3 3 2 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EFE38222.1 - 9.4e-29 99.3 8.3 9.4e-29 99.3 8.3 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.16 EFE38222.1 - 0.61 10.2 14.0 0.24 11.5 4.3 3.9 3 1 0 3 3 3 0 Eukaryotic cytochrome b561 RTA1 PF04479.13 EFE38223.1 - 1.4e-77 260.0 0.4 1.4e-77 260.0 0.4 1.5 1 1 1 2 2 2 1 RTA1 like protein DUF4131 PF13567.6 EFE38223.1 - 3.7 7.2 6.4 11 5.6 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) PhrC_PhrF PF11131.8 EFE38223.1 - 4.1 7.1 5.8 14 5.3 1.3 2.7 2 0 0 2 2 2 0 Rap-phr extracellular signalling Gaa1 PF04114.14 EFE38224.1 - 1.2e-179 598.5 6.0 1.4e-179 598.2 6.0 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component PCI PF01399.27 EFE38225.1 - 5.7e-10 39.6 0.1 1.3e-09 38.5 0.1 1.6 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 EFE38225.1 - 0.00028 20.4 0.2 0.00056 19.4 0.2 1.5 1 0 0 1 1 1 1 Rpn9 C-terminal helix Methyltransf_12 PF08242.12 EFE38226.1 - 2.3e-09 37.9 0.0 6.7e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE38226.1 - 3.1e-08 33.6 0.0 4.4e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38226.1 - 6.9e-08 32.4 0.0 9.6e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE38226.1 - 7.9e-08 32.8 0.0 3.3e-07 30.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38226.1 - 2.8e-07 31.2 0.0 7.8e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE38226.1 - 0.0006 19.2 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family GMC_oxred_N PF00732.19 EFE38227.1 - 2e-43 148.9 0.0 2.8e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFE38227.1 - 3.3e-36 124.9 0.0 4.9e-36 124.4 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_10 PF13460.6 EFE38229.1 - 4.5e-06 26.7 0.0 8.4e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFE38229.1 - 6.7e-06 25.7 0.1 2.4e-05 23.9 0.0 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFE38229.1 - 1.9e-05 23.9 0.1 3.8e-05 22.8 0.1 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EFE38229.1 - 0.00033 20.3 0.0 0.0005 19.7 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family fn3 PF00041.21 EFE38232.1 - 6e-11 42.6 3.3 5e-07 30.0 0.0 3.0 4 0 0 4 4 4 2 Fibronectin type III domain Lipase_GDSL_2 PF13472.6 EFE38232.1 - 1.4e-10 41.8 1.5 3.2e-08 34.2 0.0 2.8 3 0 0 3 3 3 2 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFE38232.1 - 0.00018 21.6 0.0 0.0004 20.4 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase HEM4 PF02602.15 EFE38233.1 - 2.3e-27 95.9 0.0 1.3e-23 83.5 0.0 2.7 1 1 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Pkinase PF00069.25 EFE38234.1 - 1.6e-63 214.5 0.0 2.5e-63 213.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38234.1 - 4.1e-29 101.6 0.0 5.7e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFE38234.1 - 0.0045 16.4 0.8 0.007 15.7 0.2 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFE38234.1 - 0.0085 15.1 0.4 0.02 13.8 0.4 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFE38234.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFE38234.1 - 0.05 13.5 0.1 0.084 12.8 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinesin PF00225.23 EFE38235.1 - 2.6e-80 269.8 0.2 3.7e-80 269.4 0.2 1.2 1 0 0 1 1 1 1 Kinesin motor domain Sec23_trunk PF04811.15 EFE38235.1 - 8.5e-71 238.3 0.0 1e-69 234.8 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EFE38235.1 - 1.9e-21 75.8 0.0 5.9e-21 74.2 0.0 1.9 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Microtub_bd PF16796.5 EFE38235.1 - 1.3e-17 64.1 0.0 2.4e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding Sec23_BS PF08033.12 EFE38235.1 - 1.7e-16 60.7 0.0 4.1e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EFE38235.1 - 5.2e-16 58.4 3.7 9.5e-16 57.6 3.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EFE38235.1 - 3.6e-06 26.8 0.0 8.3e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat HHH PF00633.23 EFE38235.1 - 0.013 15.3 0.0 0.049 13.5 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix motif Vps36-NZF-N PF16988.5 EFE38235.1 - 0.019 14.3 0.0 0.045 13.2 0.0 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain MFS_1 PF07690.16 EFE38236.1 - 2.8e-23 82.4 64.6 1.9e-17 63.3 32.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily HTH_28 PF13518.6 EFE38237.1 - 0.014 15.5 1.9 0.025 14.7 0.8 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain LZ_Tnp_IS481 PF13011.6 EFE38237.1 - 0.057 13.9 1.4 0.16 12.5 1.4 1.8 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 DUF1323 PF07037.11 EFE38237.1 - 0.073 13.5 0.8 0.37 11.2 0.1 2.1 1 1 1 2 2 2 0 Putative transcription regulator (DUF1323) Snf7 PF03357.21 EFE38237.1 - 2.7 7.6 9.5 1.1 8.8 6.7 1.7 2 0 0 2 2 2 0 Snf7 TSC22 PF01166.18 EFE38237.1 - 7.4 7.0 7.0 41 4.6 0.3 3.2 1 1 2 3 3 3 0 TSC-22/dip/bun family Chromate_transp PF02417.15 EFE38238.1 - 6e-63 211.7 37.3 5.5e-32 111.1 15.9 2.3 2 0 0 2 2 2 2 Chromate transporter HRI1 PF16815.5 EFE38239.1 - 1.2e-25 90.6 0.1 1.6e-25 90.2 0.1 1.4 1 1 0 1 1 1 1 Protein HRI1 YebF PF13995.6 EFE38239.1 - 0.081 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 YebF-like protein Peptidase_M43 PF05572.13 EFE38240.1 - 9.3e-16 58.1 0.9 1.6e-15 57.3 0.3 1.7 2 0 0 2 2 2 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 EFE38240.1 - 0.00057 20.1 1.6 0.00094 19.4 1.6 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EFE38240.1 - 0.003 17.2 0.2 0.009 15.7 0.2 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 EFE38240.1 - 0.009 16.5 0.4 0.024 15.2 0.4 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EFE38240.1 - 0.0092 15.9 0.3 0.022 14.6 0.3 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M7 PF02031.16 EFE38240.1 - 0.015 15.4 1.0 0.026 14.7 0.1 1.8 2 0 0 2 2 2 0 Streptomyces extracellular neutral proteinase (M7) family Peptidase_M10 PF00413.24 EFE38240.1 - 0.087 12.7 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Matrixin zf-C2H2_assoc PF16606.5 EFE38240.1 - 0.54 10.5 2.6 1.3 9.3 1.8 2.0 2 0 0 2 2 2 0 Unstructured conserved, between two C2H2-type zinc-fingers CPSase_L_D2 PF02786.17 EFE38241.1 - 1.5e-106 354.6 0.0 4.2e-83 278.0 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EFE38241.1 - 1.3e-41 141.8 0.0 3.1e-41 140.6 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EFE38241.1 - 2.9e-17 62.7 0.0 1.5e-07 31.2 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFE38241.1 - 1.9e-15 56.9 0.1 6.6e-07 29.1 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EFE38241.1 - 4.1e-10 39.5 0.0 0.0011 18.7 0.0 3.0 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.11 EFE38241.1 - 2.4e-05 24.0 0.0 0.036 13.7 0.0 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 EFE38241.1 - 0.0001 21.8 0.0 0.021 14.3 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 EFE38241.1 - 0.00043 20.1 0.0 0.053 13.3 0.0 2.4 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.14 EFE38241.1 - 0.004 17.2 0.0 1.9 8.5 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain Pkinase PF00069.25 EFE38243.1 - 3.2e-07 30.0 0.0 4.1e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38243.1 - 2e-06 27.3 0.0 0.00023 20.6 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFE38243.1 - 2.7e-05 24.2 0.2 3.8e-05 23.7 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFE38243.1 - 7.4e-05 22.2 0.1 0.00013 21.4 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFE38243.1 - 0.00054 19.6 0.0 0.00074 19.2 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EFE38243.1 - 0.0055 16.1 0.0 0.0072 15.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 EFE38243.1 - 0.011 15.4 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 EFE38243.1 - 0.049 12.7 0.0 0.077 12.0 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 EcKinase PF02958.20 EFE38243.1 - 0.076 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Pkinase_fungal PF17667.1 EFE38243.1 - 0.13 11.0 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase SET PF00856.28 EFE38244.1 - 4.7e-16 59.6 0.1 4.9e-15 56.3 0.0 2.2 2 0 0 2 2 2 1 SET domain zf-MYND PF01753.18 EFE38244.1 - 9.6e-10 38.4 6.4 9.6e-10 38.4 6.4 2.2 2 0 0 2 2 2 1 MYND finger Rtf2 PF04641.12 EFE38244.1 - 0.00029 20.3 0.1 0.00051 19.5 0.1 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger DUF4924 PF16271.5 EFE38244.1 - 0.013 15.6 0.4 5.4 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4924) Ribosomal_S19 PF00203.21 EFE38245.1 - 8.9e-30 102.4 0.1 1.2e-29 102.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_60s PF00428.19 EFE38246.1 - 1.9e-26 92.4 9.1 2.3e-26 92.2 9.1 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein SPT2 PF08243.11 EFE38247.1 - 3e-11 43.8 13.2 3e-11 43.8 13.2 2.2 2 0 0 2 2 2 1 SPT2 chromatin protein Carb_kinase PF01256.17 EFE38248.1 - 1.5e-46 158.9 0.7 4e-40 137.8 0.0 3.0 2 1 1 3 3 3 3 Carbohydrate kinase zf-C2H2 PF00096.26 EFE38249.1 - 0.013 15.9 39.7 0.017 15.5 0.7 6.8 6 0 0 6 6 6 0 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 EFE38249.1 - 0.16 12.3 8.1 0.54 10.6 0.6 3.0 2 1 1 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EFE38249.1 - 7.1 7.0 17.5 2.7 8.4 1.8 4.9 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Peptidase_S8 PF00082.22 EFE38250.1 - 1e-25 90.6 8.1 3.9e-25 88.7 8.0 1.8 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE38250.1 - 3.3e-14 53.3 0.0 5.6e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF3553 PF12073.8 EFE38250.1 - 0.095 12.4 0.4 0.34 10.7 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3553) CLN3 PF02487.17 EFE38250.1 - 0.19 10.8 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 CLN3 protein zf-C2H2 PF00096.26 EFE38251.1 - 0.0038 17.6 26.0 0.098 13.2 0.5 4.8 4 0 0 4 4 4 3 Zinc finger, C2H2 type FOXP-CC PF16159.5 EFE38251.1 - 0.017 15.8 1.7 0.017 15.8 1.7 3.5 2 1 1 3 3 3 0 FOXP coiled-coil domain PapD_N PF00345.20 EFE38251.1 - 0.068 13.1 0.1 0.23 11.3 0.1 1.9 1 0 0 1 1 1 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain SNARE PF05739.19 EFE38253.1 - 8.1 6.5 6.5 71 3.5 0.2 3.4 2 1 1 3 3 3 0 SNARE domain Methyltransf_16 PF10294.9 EFE38254.1 - 0.039 13.7 0.0 2.9 7.6 0.0 2.5 2 0 0 2 2 2 0 Lysine methyltransferase Peptidase_M36 PF02128.15 EFE38255.1 - 8.7e-160 531.9 1.7 1.1e-159 531.5 1.7 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EFE38255.1 - 4e-17 61.8 1.7 8.4e-17 60.7 1.7 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Med22 PF06179.12 EFE38257.1 - 1.5e-20 73.3 2.6 1.8e-20 73.1 2.6 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex DUF2225 PF09986.9 EFE38257.1 - 0.11 12.2 0.1 0.12 12.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) PrmC_N PF17827.1 EFE38257.1 - 0.19 12.3 3.3 1.7 9.2 3.3 2.1 1 1 0 1 1 1 0 PrmC N-terminal domain DHFR_1 PF00186.19 EFE38258.1 - 4.9e-18 65.3 0.1 1.4e-08 34.6 0.0 3.3 2 1 1 3 3 3 3 Dihydrofolate reductase Voltage_CLC PF00654.20 EFE38259.1 - 2.5e-84 283.5 25.0 4.3e-84 282.8 20.9 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel TAT_signal PF10518.9 EFE38259.1 - 0.18 11.7 1.2 1 9.3 1.2 2.5 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence Lipase_GDSL_2 PF13472.6 EFE38260.1 - 3.6e-20 73.1 0.0 7.5e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFE38260.1 - 9e-14 51.9 0.0 2.1e-13 50.7 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Trimer_CC PF08954.11 EFE38261.1 - 0.064 12.8 0.1 0.26 10.9 0.1 2.0 1 0 0 1 1 1 0 Trimerisation motif Isochorismatase PF00857.20 EFE38262.1 - 4.3e-26 92.2 0.0 5.7e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family HK PF02110.15 EFE38263.1 - 1.4e-71 240.8 1.4 1.9e-71 240.3 0.2 1.9 2 1 0 2 2 2 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EFE38263.1 - 3.4e-48 163.4 5.8 3.9e-27 94.8 0.2 2.6 2 0 0 2 2 2 2 Thiamine monophosphate synthase QRPTase_C PF01729.19 EFE38263.1 - 0.0019 18.0 0.0 0.0041 16.9 0.0 1.6 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain PfkB PF00294.24 EFE38263.1 - 0.024 13.9 0.0 0.046 13.0 0.0 1.4 1 0 0 1 1 1 0 pfkB family carbohydrate kinase NMO PF03060.15 EFE38263.1 - 0.039 13.3 1.5 5.9 6.2 0.1 2.6 2 0 0 2 2 2 0 Nitronate monooxygenase RPN1_RPN2_N PF17781.1 EFE38265.1 - 4.8e-118 394.1 5.6 8.7e-118 393.2 5.6 1.4 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EFE38265.1 - 6.8e-26 90.1 0.0 1.3e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EFE38265.1 - 1.1e-20 72.9 12.9 7.3e-05 23.0 0.1 8.3 7 0 0 7 7 7 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EFE38265.1 - 0.0017 18.7 0.5 3.9 7.9 0.0 4.1 4 2 1 5 5 5 2 HEAT repeats EMC3_TMCO1 PF01956.16 EFE38265.1 - 0.14 11.8 0.1 19 4.9 0.0 2.3 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Radical_SAM PF04055.21 EFE38268.1 - 6e-14 52.8 0.1 3.3e-13 50.3 0.1 2.0 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EFE38268.1 - 2.5e-07 30.8 0.1 4.9e-07 29.9 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 EFE38268.1 - 3.5e-07 30.6 0.9 6.1e-07 29.8 0.3 1.6 2 0 0 2 2 2 1 4Fe-4S single cluster domain GTP_EFTU PF00009.27 EFE38269.1 - 1.1e-57 194.8 0.0 1.5e-57 194.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFE38269.1 - 2.3e-21 76.2 0.0 4.7e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFE38269.1 - 2.6e-17 63.0 1.7 6.3e-17 61.7 1.7 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFE38269.1 - 2.2e-05 24.5 0.0 4.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EFE38269.1 - 0.015 14.8 0.2 0.13 11.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EFE38269.1 - 0.035 14.0 0.0 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 EFE38269.1 - 0.041 13.6 0.2 6.6 6.5 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IF3_N PF05198.16 EFE38270.1 - 3.1e-11 43.4 1.8 1.1e-10 41.6 0.1 2.1 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain IF3_C PF00707.22 EFE38270.1 - 5.6e-10 39.1 0.6 9.3e-10 38.3 0.6 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 EFE38270.1 - 8e-07 28.9 1.8 8e-06 25.6 1.8 2.1 1 1 0 1 1 1 1 Mitochondrial translation initiation factor GDA1_CD39 PF01150.17 EFE38271.1 - 2.2e-101 339.6 0.0 2.8e-101 339.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF4598 PF15370.6 EFE38272.1 - 2.2e-13 50.7 0.1 2.2e-13 50.7 0.1 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4598) DUF4637 PF15470.6 EFE38272.1 - 1.8 8.2 8.6 0.87 9.3 6.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4637) CENP-B_dimeris PF09026.10 EFE38272.1 - 2.5 8.6 11.5 0.88 10.0 8.5 1.7 1 1 1 2 2 2 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 EFE38272.1 - 2.9 5.9 10.5 3.2 5.7 10.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi AF-4 PF05110.13 EFE38272.1 - 7.5 4.5 18.9 6.5 4.7 18.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein IF4E PF01652.18 EFE38273.1 - 4.4e-29 101.3 0.2 5.6e-29 101.0 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E 2Fe-2S_thioredx PF01257.19 EFE38273.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin COMPASS-Shg1 PF05205.12 EFE38274.1 - 4.4e-27 94.8 0.1 4.4e-27 94.8 0.1 2.0 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 DnaB_2 PF07261.11 EFE38276.1 - 0.046 13.5 0.0 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 Replication initiation and membrane attachment Cation_efflux PF01545.21 EFE38277.1 - 9.5e-15 54.9 11.5 1.2e-14 54.5 11.5 1.1 1 0 0 1 1 1 1 Cation efflux family zf-rbx1 PF12678.7 EFE38278.1 - 2.9e-09 37.1 3.5 8.2e-09 35.6 3.5 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFE38278.1 - 3.8e-08 33.5 8.0 1.2e-07 32.0 4.1 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFE38278.1 - 2e-07 30.7 7.0 5.2e-07 29.4 2.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE38278.1 - 1.2e-06 28.4 3.5 3.5e-06 26.9 3.6 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFE38278.1 - 4.7e-06 26.4 2.0 8e-06 25.6 2.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE38278.1 - 0.00012 21.8 1.8 0.00012 21.8 1.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFE38278.1 - 0.0002 21.2 1.4 0.0002 21.2 1.4 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EFE38278.1 - 0.00025 21.0 6.7 0.00076 19.4 2.2 3.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.5 EFE38278.1 - 0.0017 18.1 10.1 0.0025 17.5 0.8 3.2 3 0 0 3 3 3 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 EFE38278.1 - 0.013 15.1 1.6 0.013 15.1 1.6 1.6 2 0 0 2 2 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EFE38278.1 - 0.02 14.9 3.4 0.046 13.8 3.4 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2921 PF11145.8 EFE38278.1 - 0.39 8.5 0.9 0.59 7.9 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) FANCL_C PF11793.8 EFE38278.1 - 1.7 8.9 5.8 5 7.4 3.5 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 EFE38278.1 - 3.8 7.7 6.9 0.41 10.8 2.0 1.9 2 0 0 2 2 2 0 RING-variant domain zf-C3H2C3 PF17122.5 EFE38278.1 - 6 7.0 4.8 2.6 8.2 1.2 2.1 2 0 0 2 2 2 0 Zinc-finger GCV_H PF01597.19 EFE38279.1 - 9.5e-39 132.1 0.7 1.1e-38 131.8 0.7 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 EFE38279.1 - 0.016 15.1 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 EFE38279.1 - 0.043 13.6 0.6 0.15 11.9 0.3 2.0 2 1 0 2 2 2 0 Biotin-requiring enzyme Ribosomal_S6 PF01250.17 EFE38280.1 - 4.4e-06 26.9 0.0 6.8e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S6 Dynamin_N PF00350.23 EFE38281.1 - 1.1e-44 152.4 0.0 2.6e-44 151.3 0.0 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFE38281.1 - 2.3e-12 46.7 0.0 5.4e-10 39.0 0.0 2.4 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EFE38281.1 - 3.2e-05 24.0 0.0 8.4e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFE38281.1 - 0.0029 18.0 0.6 0.062 13.7 0.0 2.9 3 1 0 3 3 3 1 AAA ATPase domain AAA_15 PF13175.6 EFE38281.1 - 0.011 15.5 0.6 0.2 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_21 PF13304.6 EFE38281.1 - 0.036 13.9 0.0 0.099 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system GATase_4 PF13230.6 EFE38282.1 - 0.035 13.0 0.0 0.32 9.9 0.0 2.0 1 1 1 2 2 2 0 Glutamine amidotransferases class-II PIG-Y PF15159.6 EFE38283.1 - 2.2e-23 82.9 8.6 3.6e-23 82.3 8.6 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF1218 PF06749.12 EFE38283.1 - 0.22 12.1 4.9 3 8.4 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) UPF0193 PF05250.11 EFE38283.1 - 9.2 6.0 7.6 1.4 8.7 0.7 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0193) RRM_1 PF00076.22 EFE38284.1 - 4e-56 186.7 0.0 1.3e-20 73.0 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFE38284.1 - 7.5e-07 28.9 0.0 0.0098 15.7 0.0 4.1 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_5 PF13893.6 EFE38284.1 - 1.6e-06 27.7 0.0 0.31 10.6 0.0 3.8 3 1 1 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFE38284.1 - 0.00088 19.2 0.3 9.6 6.3 0.0 3.5 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.10 EFE38284.1 - 0.0014 18.7 0.0 1.5 9.0 0.0 2.4 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_8 PF11835.8 EFE38284.1 - 0.0042 17.3 0.0 0.46 10.7 0.0 2.5 2 0 0 2 2 2 1 RRM-like domain Nup35_RRM PF05172.13 EFE38284.1 - 0.012 15.6 0.0 15 5.6 0.0 3.3 2 1 1 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EFE38284.1 - 0.015 15.4 0.0 12 6.1 0.0 3.3 3 0 0 3 3 3 0 RNA recognition motif SET_assoc PF11767.8 EFE38284.1 - 0.16 11.6 0.0 27 4.5 0.0 2.5 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Androgen_recep PF02166.16 EFE38285.1 - 0.027 13.3 0.1 0.037 12.9 0.1 1.1 1 0 0 1 1 1 0 Androgen receptor Arrestin_C PF02752.22 EFE38287.1 - 1.3e-14 54.8 0.1 6.3e-14 52.6 0.0 2.4 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFE38287.1 - 3.6e-07 30.4 0.0 0.00057 20.0 0.0 2.8 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Fringe PF02434.16 EFE38288.1 - 5.1e-05 22.8 3.2 0.00044 19.8 1.3 2.6 2 1 0 2 2 2 1 Fringe-like PAN_1 PF00024.26 EFE38288.1 - 0.018 15.0 0.3 0.059 13.3 0.3 1.8 2 0 0 2 2 2 0 PAN domain PAN_4 PF14295.6 EFE38288.1 - 0.046 13.6 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 PAN domain Acetyltransf_7 PF13508.7 EFE38289.1 - 1.5e-09 38.2 0.1 2.8e-09 37.3 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFE38289.1 - 1.5e-09 37.8 0.0 2.7e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE38289.1 - 2.4e-09 37.4 0.0 5e-09 36.4 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EFE38289.1 - 2.9e-06 27.4 0.1 0.014 15.5 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE38289.1 - 5.4e-05 23.1 0.0 9.5e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFE38289.1 - 0.0029 17.7 0.0 0.0049 17.0 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase DUF3357 PF11837.8 EFE38289.1 - 0.063 13.7 0.3 0.12 12.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) DUF4381 PF14316.6 EFE38290.1 - 0.11 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Trp_oprn_chp PF09534.10 EFE38290.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Pyr_redox_2 PF07992.14 EFE38291.1 - 9.1e-53 179.4 0.1 1.2e-52 179.0 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE38291.1 - 1.5e-10 41.5 0.0 3.1e-09 37.3 0.0 2.8 2 2 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE38291.1 - 0.0024 17.2 0.1 2.9 7.1 0.1 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EcoR124_C PF12008.8 EFE38291.1 - 0.028 14.1 1.5 0.069 12.8 0.0 2.0 2 0 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal Mito_fiss_reg PF05308.11 EFE38291.1 - 0.26 11.4 3.7 0.27 11.3 1.1 2.0 2 0 0 2 2 2 0 Mitochondrial fission regulator PRIMA1 PF16101.5 EFE38291.1 - 1.3 9.0 7.2 2.5 8.1 7.2 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF575 PF04746.12 EFE38293.1 - 0.003 17.8 0.4 0.0054 17.0 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF575) Podoplanin PF05808.11 EFE38293.1 - 0.0035 17.5 0.2 0.0075 16.4 0.2 1.5 1 0 0 1 1 1 1 Podoplanin DAP10 PF07213.11 EFE38293.1 - 0.03 14.3 0.9 0.44 10.5 0.1 2.3 2 0 0 2 2 2 0 DAP10 membrane protein TrbC PF04956.13 EFE38293.1 - 0.035 14.3 0.2 0.055 13.7 0.2 1.3 1 0 0 1 1 1 0 TrbC/VIRB2 family Herpes_gE PF02480.16 EFE38293.1 - 0.12 11.1 0.1 0.12 11.1 0.1 1.9 1 1 0 2 2 2 0 Alphaherpesvirus glycoprotein E PspB PF06667.12 EFE38293.1 - 0.18 11.9 0.0 0.31 11.1 0.0 1.3 1 0 0 1 1 1 0 Phage shock protein B Malate_synthase PF01274.22 EFE38294.1 - 8.2e-226 750.3 0.0 9.2e-226 750.1 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 EFE38294.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family PsbH PF00737.20 EFE38295.1 - 0.13 12.0 0.1 0.29 10.9 0.1 1.5 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein FMO-like PF00743.19 EFE38297.1 - 1.5e-11 43.5 0.3 1e-08 34.1 0.2 2.7 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EFE38297.1 - 6.2e-10 39.2 0.0 3.5e-09 36.7 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE38297.1 - 3e-09 36.5 0.0 0.00032 20.0 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE38297.1 - 0.00032 20.1 0.0 0.33 10.2 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFE38297.1 - 0.00077 19.1 0.3 1.4 8.4 0.0 3.1 2 1 0 3 3 3 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 EFE38297.1 - 0.0012 18.1 0.0 0.21 10.7 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EFE38297.1 - 0.029 14.9 0.6 0.39 11.3 0.0 2.6 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFE38297.1 - 0.041 13.9 0.0 0.5 10.3 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.17 EFE38297.1 - 0.11 11.7 0.0 0.35 10.1 0.0 1.7 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 EFE38297.1 - 0.14 10.9 0.3 0.31 9.7 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Glyco_hydro_3_C PF01915.22 EFE38298.1 - 3e-46 157.9 0.0 6e-46 157.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFE38298.1 - 4.3e-35 121.6 0.0 6.3e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFE38298.1 - 1.6e-22 79.4 0.1 3.6e-22 78.3 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain Serpin PF00079.20 EFE38299.1 - 3.4e-55 187.8 0.0 4.4e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) AA_permease_2 PF13520.6 EFE38300.1 - 4.3e-52 177.4 52.7 5.3e-52 177.1 52.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE38300.1 - 3.7e-20 72.0 38.9 5.2e-20 71.5 38.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4668 PF15701.5 EFE38300.1 - 0.25 11.2 0.1 0.25 11.2 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4668) LapA_dom PF06305.11 EFE38300.1 - 2 8.3 5.8 0.45 10.4 0.1 2.9 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain GST_N_2 PF13409.6 EFE38301.1 - 1.1e-12 48.1 0.0 2.4e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFE38301.1 - 1.5e-09 38.1 0.0 3.2e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFE38301.1 - 0.00024 21.1 0.1 0.0012 18.8 0.0 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFE38301.1 - 0.0021 18.2 0.0 0.0039 17.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFE38301.1 - 0.011 15.9 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ABC_tran PF00005.27 EFE38302.1 - 7.3e-45 152.8 0.1 2.6e-24 86.3 0.0 4.1 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFE38302.1 - 3.2e-15 56.7 0.8 0.00041 20.3 0.0 4.5 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFE38302.1 - 2.8e-11 43.3 0.3 0.0012 18.4 0.0 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain Chromo PF00385.24 EFE38302.1 - 2.4e-08 33.8 0.1 5e-08 32.7 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MMR_HSR1 PF01926.23 EFE38302.1 - 3.1e-08 33.7 0.0 0.013 15.6 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EFE38302.1 - 7.8e-07 29.8 1.3 0.0062 17.1 0.0 3.1 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EFE38302.1 - 8.6e-07 29.0 0.1 0.027 14.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EFE38302.1 - 1.7e-05 24.4 2.5 0.11 12.3 1.2 2.9 2 1 1 3 3 3 2 P-loop containing region of AAA domain DUF87 PF01935.17 EFE38302.1 - 0.00021 21.5 1.1 0.064 13.4 0.1 3.4 3 0 0 3 3 2 1 Helicase HerA, central domain HEAT PF02985.22 EFE38302.1 - 0.00042 20.3 0.6 0.64 10.4 0.5 4.5 5 0 0 5 5 4 1 HEAT repeat AAA_28 PF13521.6 EFE38302.1 - 0.00044 20.5 0.0 0.018 15.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFE38302.1 - 0.00045 20.2 0.7 0.24 11.3 0.0 2.9 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EFE38302.1 - 0.00045 20.5 0.0 0.81 10.0 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EFE38302.1 - 0.00068 19.4 0.0 0.88 9.2 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain RNA_helicase PF00910.22 EFE38302.1 - 0.0018 18.7 0.1 1.8 9.0 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 EFE38302.1 - 0.0035 17.9 0.5 8.7 6.9 0.0 3.6 4 0 0 4 4 3 0 AAA domain SbcCD_C PF13558.6 EFE38302.1 - 0.0075 16.5 0.0 8.2 6.7 0.0 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Roc PF08477.13 EFE38302.1 - 0.012 15.8 0.1 8.8 6.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EFE38302.1 - 0.018 14.8 0.5 2 8.1 0.1 2.5 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EFE38302.1 - 0.019 13.9 0.4 4 6.3 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 EFE38302.1 - 0.023 13.9 0.4 0.93 8.6 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain PduV-EutP PF10662.9 EFE38302.1 - 0.027 14.2 0.1 0.92 9.3 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP-synt_ab PF00006.25 EFE38302.1 - 0.028 14.1 0.1 5 6.7 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 EFE38302.1 - 0.036 14.5 0.1 2.9 8.3 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF1666 PF07891.12 EFE38302.1 - 0.04 13.6 0.1 0.16 11.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1666) AAA_13 PF13166.6 EFE38302.1 - 0.055 12.1 0.0 4.7 5.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain SR-25 PF10500.9 EFE38302.1 - 0.058 13.0 0.5 0.11 12.1 0.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_33 PF13671.6 EFE38302.1 - 0.058 13.5 0.0 12 6.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 EFE38302.1 - 0.075 12.9 0.0 3.3 7.6 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 MukB PF04310.12 EFE38302.1 - 0.1 12.4 0.3 2 8.2 0.1 2.3 2 0 0 2 2 2 0 MukB N-terminal DUF3584 PF12128.8 EFE38302.1 - 0.11 10.0 2.9 1.2 6.6 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_16 PF13191.6 EFE38302.1 - 0.12 12.8 0.1 35 4.7 0.0 3.2 3 0 0 3 3 3 0 AAA ATPase domain AAA_30 PF13604.6 EFE38302.1 - 0.17 11.6 4.7 1.2 8.8 0.2 2.9 3 0 0 3 3 2 0 AAA domain DUF815 PF05673.13 EFE38302.1 - 0.18 10.9 0.5 6.2 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Glyco_hydro_92 PF07971.12 EFE38303.1 - 1.1e-147 492.7 0.2 1.4e-147 492.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EFE38303.1 - 1e-59 202.3 0.5 1.7e-59 201.6 0.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Citrate_synt PF00285.21 EFE38304.1 - 1.1e-97 327.4 0.0 1.3e-97 327.1 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain ICL PF00463.21 EFE38305.1 - 4.3e-195 649.2 0.1 5.1e-195 648.9 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EFE38305.1 - 2.5e-10 40.2 0.0 1.6e-09 37.6 0.0 1.9 1 1 1 2 2 2 1 Phosphoenolpyruvate phosphomutase AMP-binding PF00501.28 EFE38306.1 - 1.2e-65 221.8 0.0 1.5e-65 221.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE38306.1 - 1.2e-05 26.2 0.1 2.8e-05 25.0 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1661 PF07877.11 EFE38306.1 - 0.14 11.9 0.4 0.31 10.7 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1661) MmgE_PrpD PF03972.14 EFE38307.1 - 1.6e-146 488.3 0.0 1.8e-146 488.2 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family NPBW PF15180.6 EFE38308.1 - 0.0077 16.1 0.5 0.0077 16.1 0.5 1.8 2 1 0 2 2 2 1 Neuropeptides B and W DNA_methylase PF00145.17 EFE38309.1 - 3.4e-41 141.7 0.0 5e-31 108.3 0.0 2.1 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase GATase_6 PF13522.6 EFE38310.1 - 1.4e-12 48.0 0.0 3.3e-12 46.8 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EFE38310.1 - 2.6e-11 43.5 0.0 7.4e-11 42.0 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EFE38310.1 - 8.9e-07 28.5 0.0 2.2e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EFE38310.1 - 0.00014 20.9 0.0 0.00032 19.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferases class-II HhH-GPD PF00730.25 EFE38311.1 - 1.2e-07 32.1 0.0 2.4e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Aldedh PF00171.22 EFE38312.1 - 1.8e-117 392.7 0.0 3.3e-117 391.8 0.0 1.3 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Pkinase PF00069.25 EFE38314.1 - 1.2e-33 116.6 0.0 2.2e-33 115.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38314.1 - 2.5e-22 79.4 0.0 4.6e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE38314.1 - 0.0018 18.3 0.0 0.01 15.8 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE38314.1 - 0.011 14.5 0.1 0.02 13.7 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 EFE38314.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 EFE38314.1 - 0.021 14.2 0.1 0.045 13.1 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mt_ATP-synt_D PF05873.12 EFE38316.1 - 1.2e-20 73.9 1.4 1.7e-20 73.4 1.4 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) E3_UbLigase_R4 PF13764.6 EFE38316.1 - 0.016 13.4 0.5 0.019 13.2 0.5 1.0 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 DUF948 PF06103.11 EFE38316.1 - 0.18 12.1 0.7 1 9.6 0.4 2.3 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) NAC PF01849.18 EFE38317.1 - 3.2e-22 78.2 0.0 1.1e-21 76.5 0.0 1.9 2 0 0 2 2 2 1 NAC domain Cytomega_UL84 PF06284.11 EFE38317.1 - 0.19 10.2 0.6 0.22 9.9 0.6 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Shadoo PF14999.6 EFE38317.1 - 0.2 11.8 3.2 0.36 10.9 3.2 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective PGA2 PF07543.12 EFE38317.1 - 6.9 6.6 12.0 3.2 7.7 7.8 2.0 2 0 0 2 2 2 0 Protein trafficking PGA2 Myc_N PF01056.18 EFE38317.1 - 8 6.2 9.1 1.8 8.4 5.4 1.6 1 1 0 2 2 2 0 Myc amino-terminal region Ribosomal_L14e PF01929.17 EFE38318.1 - 1.5e-31 108.7 1.6 1.9e-31 108.3 1.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EFE38318.1 - 1.3e-06 28.1 0.1 2.2e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 KOW motif MFS_1 PF07690.16 EFE38319.1 - 5.6e-38 130.8 19.3 1e-24 87.2 5.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE38319.1 - 1.6e-11 43.7 13.3 4e-11 42.5 5.3 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 EFE38319.1 - 5.3e-06 25.6 7.1 0.00035 19.5 0.2 3.5 2 2 1 3 3 3 2 MFS_1 like family MFS_4 PF06779.14 EFE38319.1 - 6.7e-06 25.6 3.7 6.7e-06 25.6 3.7 2.3 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.6 EFE38319.1 - 1.7e-05 23.6 12.8 0.0072 14.9 2.6 3.6 2 2 1 3 3 3 3 MFS/sugar transport protein Folate_carrier PF01770.18 EFE38319.1 - 0.0015 17.3 0.0 0.0027 16.5 0.0 1.3 1 0 0 1 1 1 1 Reduced folate carrier LacY_symp PF01306.19 EFE38319.1 - 0.0047 15.7 3.2 0.14 10.9 0.1 2.3 2 1 0 2 2 2 2 LacY proton/sugar symporter MFS_3 PF05977.13 EFE38319.1 - 0.027 12.9 1.4 0.22 9.9 0.8 2.3 1 1 0 1 1 1 0 Transmembrane secretion effector TRI12 PF06609.13 EFE38319.1 - 0.3 9.5 4.4 0.085 11.3 0.4 1.9 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) SRP-alpha_N PF04086.13 EFE38320.1 - 3.2e-75 253.7 0.0 4.3e-75 253.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 EFE38320.1 - 2.1e-50 171.1 0.0 3.6e-50 170.3 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EFE38320.1 - 6.9e-10 39.0 0.1 1.9e-09 37.6 0.1 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EFE38320.1 - 2.2e-06 26.9 0.0 3.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EFE38320.1 - 0.0007 19.4 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFE38320.1 - 0.0079 16.6 0.0 0.03 14.7 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EFE38320.1 - 0.0083 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EFE38320.1 - 0.013 15.6 0.0 0.049 13.7 0.1 2.0 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFE38320.1 - 0.03 14.3 0.2 0.25 11.2 0.0 2.1 1 1 1 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFE38320.1 - 0.03 14.4 0.1 0.15 12.1 0.1 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 EFE38320.1 - 0.033 13.8 0.0 0.066 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 EFE38320.1 - 0.053 13.0 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_17 PF13207.6 EFE38320.1 - 0.055 13.9 0.1 0.34 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFE38320.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain YIF1 PF03878.15 EFE38321.1 - 2.9e-98 328.2 4.0 3.4e-98 327.9 4.0 1.0 1 0 0 1 1 1 1 YIF1 Catalase PF00199.19 EFE38322.1 - 4.4e-168 559.3 3.6 2.4e-166 553.6 3.6 2.1 1 1 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EFE38322.1 - 5.9e-16 58.4 0.0 1.1e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 EFE38322.1 - 2.3e-08 33.8 0.3 1.4e-07 31.2 0.0 2.3 3 0 0 3 3 3 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 EFE38322.1 - 0.00046 20.0 0.0 0.00096 19.0 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family PH_RBD PF12068.8 EFE38324.1 - 2.1e-07 30.6 0.0 1.2e-05 24.8 0.0 3.0 2 1 0 2 2 2 1 Rab-binding domain (RBD) RabGAP-TBC PF00566.18 EFE38325.1 - 7.3e-35 120.6 5.6 1.4e-34 119.7 5.6 1.4 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Peptidase_M60 PF13402.6 EFE38325.1 - 0.023 14.2 0.5 0.063 12.8 0.0 1.7 1 1 1 2 2 2 0 Peptidase M60, enhancin and enhancin-like GAS2 PF02187.17 EFE38326.1 - 4.5e-06 26.7 0.3 1e-05 25.6 0.3 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Hus1 PF04005.12 EFE38327.1 - 1.1e-101 339.9 0.0 7.3e-95 317.4 0.0 2.1 1 1 1 2 2 2 2 Hus1-like protein Sec16_C PF12931.7 EFE38328.1 - 7.7e-112 373.8 0.1 1.1e-111 373.4 0.1 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16_N PF12935.7 EFE38328.1 - 2.7e-57 194.7 24.8 2.7e-57 194.7 24.8 4.7 4 1 0 4 4 4 2 Vesicle coat trafficking protein Sec16 N-terminus Sec16 PF12932.7 EFE38328.1 - 7.3e-33 113.7 0.0 1.7e-32 112.5 0.0 1.7 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region PhoLip_ATPase_C PF16212.5 EFE38329.1 - 3.1e-46 158.2 7.3 3.1e-46 158.2 7.3 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFE38329.1 - 6.8e-16 57.7 2.1 1.4e-15 56.7 2.1 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EFE38329.1 - 5.8e-13 49.6 0.3 7.7e-08 32.9 0.1 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE38329.1 - 8.7e-10 38.6 0.2 5.8e-07 29.5 0.0 3.7 3 1 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFE38329.1 - 1.8e-05 24.3 1.1 0.051 13.1 0.0 2.5 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase_3 PF08282.12 EFE38329.1 - 0.012 15.3 0.0 0.03 14.1 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HIGH_NTase1_ass PF16581.5 EFE38329.1 - 0.033 14.2 0.1 0.078 13.0 0.0 1.6 2 0 0 2 2 2 0 Cytidyltransferase-related C-terminal region Mso1_Sec1_bdg PF14475.6 EFE38330.1 - 4.7e-13 48.5 0.0 8.4e-13 47.7 0.0 1.5 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Mak16 PF04874.14 EFE38331.1 - 1.9e-30 105.4 14.0 1.9e-30 105.4 14.0 2.4 2 0 0 2 2 2 1 Mak16 protein C-terminal region Ribosomal_L28e PF01778.17 EFE38331.1 - 1.7e-15 57.7 0.0 3.3e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal L28e protein family BUD22 PF09073.10 EFE38331.1 - 7.3e-06 25.6 15.2 8.9e-06 25.3 15.2 1.1 1 0 0 1 1 1 1 BUD22 PYC_OADA PF02436.18 EFE38331.1 - 0.018 14.8 1.3 0.03 14.0 0.9 1.5 1 1 0 1 1 1 0 Conserved carboxylase domain TFIIF_alpha PF05793.12 EFE38331.1 - 0.085 11.4 25.7 0.096 11.3 25.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 EFE38331.1 - 1.9 6.6 28.4 2.2 6.4 28.4 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EFE38331.1 - 5.7 5.1 25.2 0.14 10.4 18.2 1.6 2 0 0 2 2 2 0 CDC45-like protein zf-B_box PF00643.24 EFE38332.1 - 0.068 13.3 1.2 0.1 12.8 1.2 1.4 1 0 0 1 1 1 0 B-box zinc finger zf-C2H2_4 PF13894.6 EFE38332.1 - 0.17 12.8 2.2 0.24 12.3 1.4 1.7 1 1 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE38332.1 - 0.27 11.8 1.9 0.5 10.9 1.9 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type ECH_1 PF00378.20 EFE38333.1 - 6.1e-25 88.0 0.0 7.4e-25 87.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFE38333.1 - 8.3e-19 68.3 0.0 9.4e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase D123 PF07065.14 EFE38334.1 - 3.7e-111 371.2 0.1 4.7e-111 370.8 0.1 1.1 1 0 0 1 1 1 1 D123 Vps51 PF08700.11 EFE38335.1 - 5.7e-14 52.0 0.4 3.8e-13 49.3 0.0 2.6 2 0 0 2 2 2 1 Vps51/Vps67 DUF3461 PF11944.8 EFE38335.1 - 0.05 13.7 0.3 0.2 11.8 0.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) COG2 PF06148.11 EFE38335.1 - 0.071 13.2 0.0 0.37 10.9 0.0 2.2 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 SURF6 PF04935.12 EFE38335.1 - 0.19 11.5 3.7 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Surfeit locus protein 6 TRIF-NTD PF17798.1 EFE38335.1 - 0.28 11.3 2.7 0.7 10.0 0.3 2.5 2 0 0 2 2 2 0 TRIF N-terminal domain DUF1640 PF07798.11 EFE38336.1 - 2.2e-35 122.2 7.6 3.2e-35 121.8 7.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HIP1_clath_bdg PF16515.5 EFE38336.1 - 0.0013 19.3 2.1 0.0036 17.9 2.1 1.8 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 ALMT PF11744.8 EFE38336.1 - 0.0067 15.3 1.1 0.012 14.5 1.1 1.5 1 0 0 1 1 1 1 Aluminium activated malate transporter DUF1387 PF07139.11 EFE38336.1 - 0.075 12.8 9.9 0.33 10.7 8.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1387) Baculo_PEP_C PF04513.12 EFE38336.1 - 0.83 9.7 5.9 1.5 8.8 5.9 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HEAT_2 PF13646.6 EFE38337.1 - 1.3e-07 31.9 0.1 0.088 13.2 0.0 5.8 5 1 0 5 5 5 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EFE38337.1 - 0.00043 20.8 0.0 0.051 14.2 0.0 4.0 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EFE38337.1 - 0.00061 19.8 6.6 2.1 8.8 0.0 8.0 9 0 0 9 9 9 1 HEAT repeat HEAT_EZ PF13513.6 EFE38337.1 - 0.016 15.7 6.0 30 5.3 0.0 6.5 6 0 0 6 6 6 0 HEAT-like repeat Arm PF00514.23 EFE38337.1 - 0.017 15.2 0.2 3.5 7.8 0.0 4.8 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EFE38337.1 - 0.017 15.3 0.1 62 3.8 0.0 4.8 5 0 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 EFE38337.1 - 0.024 13.2 1.2 6.4 5.2 0.0 3.8 4 0 0 4 4 4 0 Adaptin N terminal region Transcrip_reg PF01709.20 EFE38338.1 - 2.3e-48 164.7 0.1 2.6e-48 164.5 0.1 1.0 1 0 0 1 1 1 1 Transcriptional regulator CENP-I PF07778.11 EFE38339.1 - 1.1e-44 153.0 0.7 7.2e-44 150.4 0.7 1.8 1 1 0 1 1 1 1 Mis6 Sedlin_N PF04628.13 EFE38339.1 - 0.019 15.1 0.0 0.28 11.3 0.0 2.5 2 0 0 2 2 2 0 Sedlin, N-terminal conserved region DUF4360 PF14273.6 EFE38340.1 - 3.6e-70 235.4 2.4 4.3e-70 235.2 2.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) CLPTM1 PF05602.12 EFE38341.1 - 1.8e-148 495.1 0.4 2.2e-148 494.9 0.4 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) MtN3_slv PF03083.16 EFE38341.1 - 0.33 11.0 3.5 0.14 12.3 0.3 2.0 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange SyrA PF11089.8 EFE38341.1 - 0.42 10.7 2.3 16 5.6 0.6 2.6 2 0 0 2 2 2 0 Exopolysaccharide production repressor adh_short PF00106.25 EFE38342.1 - 3e-20 72.5 0.0 6.2e-20 71.5 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE38342.1 - 1.6e-14 54.1 0.0 2.6e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ASXH PF13919.6 EFE38343.1 - 4.3e-25 88.4 0.7 1.6e-24 86.5 0.7 2.0 1 1 0 1 1 1 1 Asx homology domain Longin PF13774.6 EFE38344.1 - 5.3e-20 71.2 0.1 9.1e-20 70.5 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EFE38344.1 - 2.9e-15 55.8 0.6 1e-14 54.1 0.0 1.9 2 0 0 2 2 2 1 Synaptobrevin SLM4 PF16818.5 EFE38344.1 - 0.038 14.0 0.7 0.92 9.5 0.0 2.2 1 1 1 2 2 2 0 Protein SLM4 SIMPL PF04402.14 EFE38344.1 - 0.19 12.2 2.0 0.92 9.9 2.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF541) DUF1664 PF07889.12 EFE38344.1 - 0.85 9.7 7.1 0.28 11.2 0.6 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) YgaB PF14182.6 EFE38344.1 - 1 9.8 3.4 0.84 10.1 0.2 2.2 2 1 1 3 3 3 0 YgaB-like protein EMP24_GP25L PF01105.24 EFE38344.1 - 3.5 7.5 6.7 32 4.4 6.7 2.2 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Elong_Iki1 PF10483.9 EFE38345.1 - 4.3e-98 328.5 0.0 5.7e-98 328.1 0.0 1.1 1 0 0 1 1 1 1 Elongator subunit Iki1 SNRNP27 PF08648.12 EFE38346.1 - 2.4e-27 94.8 1.4 2.7e-27 94.6 1.4 1.0 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins DAO PF01266.24 EFE38347.1 - 1.3e-69 235.5 0.7 1.4e-69 235.3 0.7 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE38347.1 - 1.5e-07 31.6 0.3 6e-07 29.6 0.3 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE38347.1 - 1.7e-06 27.5 0.0 0.0069 15.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFE38347.1 - 0.0003 20.0 0.1 0.0024 17.0 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EFE38347.1 - 0.00071 18.9 0.1 0.0013 18.0 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 EFE38347.1 - 0.0013 17.7 0.0 0.12 11.2 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.27 EFE38347.1 - 0.0019 18.7 0.1 0.013 16.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EFE38347.1 - 0.0062 15.4 0.1 0.012 14.4 0.1 1.4 2 0 0 2 2 2 1 MCRA family NAD_binding_9 PF13454.6 EFE38347.1 - 0.024 14.6 0.1 0.099 12.6 0.1 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding Sacchrp_dh_NADP PF03435.18 EFE38347.1 - 0.031 14.5 0.1 0.2 11.9 0.1 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain GIDA PF01134.22 EFE38347.1 - 0.046 12.8 0.1 4.5 6.3 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFE38347.1 - 0.099 12.0 0.2 6 6.1 0.1 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Glyco_hydro_63 PF03200.16 EFE38348.1 - 1.3e-169 565.1 4.0 1.3e-169 565.1 4.0 2.7 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EFE38348.1 - 5.1e-89 298.2 0.0 4.8e-88 295.1 0.0 2.3 3 0 0 3 3 3 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EFE38348.1 - 0.0082 15.0 2.1 0.024 13.5 2.0 1.7 1 1 0 1 1 1 1 Trehalase MMtag PF10159.9 EFE38349.1 - 2.4e-33 114.2 3.4 2.4e-33 114.2 3.4 1.7 2 0 0 2 2 2 1 Multiple myeloma tumor-associated CRT10 PF08728.10 EFE38350.1 - 1.9e-15 56.2 0.0 4e-09 35.2 0.0 2.2 2 0 0 2 2 2 2 CRT10 DUF568 PF04526.13 EFE38350.1 - 0.11 13.3 0.2 0.25 12.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF568) WD40 PF00400.32 EFE38350.1 - 0.23 12.4 1.2 0.66 10.9 0.2 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat YL1 PF05764.13 EFE38350.1 - 5.6 7.0 13.2 9.4 6.3 13.2 1.3 1 0 0 1 1 1 0 YL1 nuclear protein DUF3402 PF11882.8 EFE38351.1 - 3.1e-163 544.2 0.0 4.1e-163 543.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.13 EFE38351.1 - 1.8e-85 286.7 0.0 2.7e-85 286.1 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein IBR PF01485.21 EFE38352.1 - 1.8e-18 66.5 41.2 6.3e-16 58.4 3.1 4.1 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 EFE38352.1 - 1.5e-16 60.8 0.1 4.1e-16 59.3 0.1 1.8 1 1 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 EFE38352.1 - 0.027 14.8 9.1 0.027 14.8 9.1 4.1 3 1 1 4 4 4 0 Ring finger domain PAP2 PF01569.21 EFE38353.1 - 6.2e-14 51.9 3.9 8.2e-14 51.5 3.9 1.1 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 EFE38353.1 - 0.055 13.6 2.5 6.5 6.9 0.1 2.3 1 1 1 2 2 2 0 Divergent PAP2 family Ldh_2 PF02615.14 EFE38354.1 - 8.1e-129 429.5 0.1 9.1e-129 429.4 0.1 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Pet100 PF09803.9 EFE38355.1 - 7.8e-19 68.0 0.1 1.3e-18 67.2 0.1 1.4 1 0 0 1 1 1 1 Pet100 RF-1 PF00472.20 EFE38356.1 - 9e-15 54.6 12.6 6.6e-12 45.4 9.6 2.3 2 0 0 2 2 2 2 RF-1 domain CAS_CSE1 PF03378.15 EFE38357.1 - 3.8e-121 404.7 0.0 4.2e-121 404.5 0.0 1.0 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EFE38358.1 - 5.6e-156 519.0 3.4 7.9e-156 518.5 3.4 1.2 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 EFE38358.1 - 2.8e-45 154.6 0.2 8.8e-45 153.0 0.2 1.9 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 EFE38358.1 - 6.2e-17 61.3 0.4 2.6e-16 59.3 0.1 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFE38358.1 - 0.018 15.1 0.1 1 9.4 0.0 3.5 3 0 0 3 3 3 0 Exportin 1-like protein V-ATPase_H_N PF03224.14 EFE38358.1 - 0.057 12.7 1.7 0.12 11.7 0.1 2.3 2 1 1 3 3 3 0 V-ATPase subunit H DUF3384 PF11864.8 EFE38359.1 - 1.2e-88 298.2 0.3 4.6e-88 296.2 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 EFE38359.1 - 1.1e-46 158.8 0.0 1.8e-46 158.1 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 EFE38359.1 - 3.4e-40 138.2 1.2 3.1e-35 121.9 0.0 3.2 3 0 0 3 3 3 2 Tuberin PUF PF00806.19 EFE38360.1 - 1.4e-57 188.2 7.0 1.8e-07 30.5 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat BLOC1S3 PF15753.5 EFE38362.1 - 0.085 13.0 2.9 0.088 12.9 2.9 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 DUF3362 PF11842.8 EFE38362.1 - 7.2 6.9 9.9 8.4 6.7 9.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3362) MAP17 PF15807.5 EFE38362.1 - 8.4 6.6 7.6 10 6.4 7.6 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF5326 PF17260.2 EFE38363.1 - 0.053 13.7 0.1 0.078 13.1 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5326) Phosphodiest PF01663.22 EFE38364.1 - 8.7e-16 58.5 0.4 1.4e-15 57.7 0.4 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EFE38364.1 - 8.9e-05 22.0 0.8 0.00017 21.0 0.8 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EFE38364.1 - 0.00066 19.2 0.1 0.0011 18.4 0.1 1.4 1 0 0 1 1 1 1 Sulfatase PglZ PF08665.12 EFE38364.1 - 0.15 12.2 0.8 13 5.8 0.1 2.3 2 0 0 2 2 2 0 PglZ domain Borrelia_P13 PF05628.12 EFE38364.1 - 0.25 11.3 1.6 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 Borrelia membrane protein P13 cwf21 PF08312.12 EFE38365.1 - 1.3e-14 54.0 22.4 4.6e-14 52.3 22.4 2.0 1 1 0 1 1 1 1 cwf21 domain Peptidase_S64 PF08192.11 EFE38365.1 - 0.06 11.8 2.3 0.1 11.1 2.3 1.3 1 0 0 1 1 1 0 Peptidase family S64 FapA PF03961.13 EFE38365.1 - 2.4 6.7 9.3 3.5 6.1 9.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A FemAB PF02388.16 EFE38365.1 - 8.3 5.2 10.1 13 4.5 10.1 1.2 1 0 0 1 1 1 0 FemAB family Atg14 PF10186.9 EFE38365.1 - 9.1 5.3 12.7 13 4.8 12.7 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HA2 PF04408.23 EFE38366.1 - 5.9e-28 97.3 0.0 5.9e-28 97.3 0.0 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFE38366.1 - 3.6e-12 46.5 0.0 9.1e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFE38366.1 - 3.6e-12 46.6 0.1 1.7e-11 44.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE38366.1 - 3.2e-09 36.8 0.0 1.2e-07 31.7 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EFE38366.1 - 0.0015 18.6 0.0 2.3 8.2 0.0 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFE38366.1 - 0.0049 17.2 0.0 0.0095 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFE38366.1 - 0.012 15.9 0.0 0.053 13.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFE38366.1 - 0.025 15.1 0.0 0.025 15.1 0.0 3.6 4 0 0 4 4 4 0 AAA domain AAA_30 PF13604.6 EFE38366.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFE38366.1 - 0.052 13.3 0.4 0.1 12.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EFE38366.1 - 0.06 12.4 0.4 0.23 10.5 0.0 2.1 3 0 0 3 3 3 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EFE38366.1 - 0.085 12.2 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family PAC3 PF10178.9 EFE38367.1 - 0.0012 18.9 0.0 0.093 12.9 0.0 2.2 2 0 0 2 2 2 2 Proteasome assembly chaperone 3 TLP1_add_C PF18313.1 EFE38368.1 - 1.2e-23 82.8 0.0 2.8e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 Thiolase-like protein type 1 additional C-terminal domain Arc_C PF18162.1 EFE38368.1 - 0.17 11.7 0.0 4.8 7.1 0.0 2.3 2 0 0 2 2 2 0 Arc C-lobe Cohesin_load PF10345.9 EFE38369.1 - 1.4e-158 529.1 5.0 1.7e-158 528.8 5.0 1.0 1 0 0 1 1 1 1 Cohesin loading factor Lactamase_B_4 PF13691.6 EFE38369.1 - 0.043 13.5 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 tRNase Z endonuclease DUF3663 PF12404.8 EFE38369.1 - 0.45 10.6 1.6 23 5.1 0.4 2.5 2 0 0 2 2 2 0 Peptidase TPR_4 PF07721.14 EFE38369.1 - 8.3 7.4 8.6 18 6.3 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DER1 PF04511.15 EFE38370.1 - 2.1e-27 96.3 0.1 2.6e-27 96.0 0.1 1.0 1 0 0 1 1 1 1 Der1-like family EMP70 PF02990.16 EFE38371.1 - 1.6e-162 541.8 0.0 2.1e-162 541.5 0.0 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 ubiquitin PF00240.23 EFE38372.1 - 2.2e-19 69.0 0.0 3.5e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EFE38372.1 - 1.1e-07 31.6 0.1 2.4e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 EFE38372.1 - 2.8e-05 23.9 0.0 4.7e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFE38372.1 - 0.00029 21.3 1.2 0.00071 20.1 0.0 2.1 3 0 0 3 3 3 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFE38372.1 - 0.00037 20.6 0.0 0.00097 19.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like STI1 PF17830.1 EFE38372.1 - 0.014 15.3 19.7 0.026 14.5 1.3 3.2 3 0 0 3 3 3 0 STI1 domain HOIP-UBA PF16678.5 EFE38372.1 - 0.043 13.8 0.0 0.077 13.0 0.0 1.3 1 0 0 1 1 1 0 HOIP UBA domain pair GerD PF17898.1 EFE38372.1 - 0.15 12.0 4.0 0.46 10.5 3.2 2.1 1 1 1 2 2 2 0 Spore germination GerD central core domain MMS1_N PF10433.9 EFE38373.1 - 4.8e-159 530.1 0.0 6.5e-159 529.7 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term ANAPC4_WD40 PF12894.7 EFE38373.1 - 0.017 15.4 0.0 0.72 10.2 0.0 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain CPSF_A PF03178.15 EFE38374.1 - 6.2e-102 341.2 0.0 7.4e-102 341.0 0.0 1.1 1 0 0 1 1 1 1 CPSF A subunit region CN_hydrolase PF00795.22 EFE38375.1 - 1.5e-33 116.2 0.0 2e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase BP28CT PF08146.12 EFE38376.1 - 7.2e-43 146.2 0.6 3e-42 144.1 0.3 2.4 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EFE38376.1 - 1.2e-25 90.1 1.1 1.2e-25 90.1 1.1 5.2 5 0 0 5 5 5 1 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.6 EFE38376.1 - 4.6e-05 23.7 9.1 0.27 11.6 0.1 7.0 7 1 0 7 7 7 1 HEAT repeats Adaptin_N PF01602.20 EFE38376.1 - 0.00013 20.7 5.0 0.0034 16.0 0.1 4.4 4 1 0 4 4 4 1 Adaptin N terminal region Nipped-B_C PF12830.7 EFE38376.1 - 0.07 13.1 1.2 24 4.8 0.0 4.5 5 0 0 5 5 5 0 Sister chromatid cohesion C-terminus HEAT PF02985.22 EFE38376.1 - 1 9.8 10.7 1.3 9.5 0.0 6.3 8 0 0 8 8 8 0 HEAT repeat DUF4925 PF16272.5 EFE38376.1 - 1.2 8.5 5.8 1.1 8.7 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4925) HEAT_EZ PF13513.6 EFE38376.1 - 9.9 6.8 18.0 7.9 7.1 0.1 7.5 8 0 0 8 8 8 0 HEAT-like repeat NRDE-2 PF08424.10 EFE38377.1 - 1.3e-93 313.7 0.2 2.7e-92 309.4 0.0 2.8 3 0 0 3 3 3 1 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 EFE38377.1 - 0.028 15.2 5.1 22 6.2 0.0 5.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFE38377.1 - 0.068 13.6 1.9 0.15 12.5 0.4 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EFE38377.1 - 0.33 10.9 1.7 4.8 7.2 0.1 3.0 3 0 0 3 3 3 0 Mad3/BUB1 homology region 1 UDG PF03167.19 EFE38378.1 - 5.2e-19 68.8 0.0 3.6e-18 66.0 0.0 2.0 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily 7TMR-DISM_7TM PF07695.11 EFE38379.1 - 0.27 11.1 7.9 0.72 9.7 7.9 1.6 1 1 0 1 1 1 0 7TM diverse intracellular signalling NAD_binding_6 PF08030.12 EFE38380.1 - 1.7e-23 83.5 0.0 3.7e-23 82.4 0.0 1.6 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFE38380.1 - 1.1e-22 80.1 0.0 2.6e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EFE38380.1 - 1.1e-20 74.0 10.5 2.4e-20 72.9 10.5 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 EFE38380.1 - 0.045 14.1 0.0 0.092 13.1 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFE38380.1 - 0.051 14.2 0.0 5.2 7.8 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain SBDS PF01172.18 EFE38381.1 - 1.4e-25 89.1 0.1 1.7e-25 88.9 0.1 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein RhoGEF PF00621.20 EFE38382.1 - 3.8e-19 69.6 0.1 3.8e-18 66.4 0.1 2.3 1 1 0 1 1 1 1 RhoGEF domain DUF4611 PF15387.6 EFE38383.1 - 0.29 11.4 1.9 0.43 10.8 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Ni_hydr_CYTB PF01292.20 EFE38383.1 - 0.63 9.6 7.8 0.16 11.5 2.4 2.0 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Methyltransf_23 PF13489.6 EFE38385.1 - 0.055 13.3 0.0 0.055 13.3 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain IFRD PF05004.13 EFE38386.1 - 8.1e-82 274.7 11.5 1e-81 274.4 11.5 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) CoiA PF06054.11 EFE38386.1 - 0.17 11.0 0.2 0.99 8.5 0.0 2.0 2 0 0 2 2 2 0 Competence protein CoiA-like family RRN3 PF05327.11 EFE38386.1 - 0.4 9.2 13.5 0.65 8.5 4.0 2.1 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 ORC6 PF05460.13 EFE38386.1 - 3.2 6.9 10.2 0.19 11.0 3.8 1.9 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) RXT2_N PF08595.11 EFE38386.1 - 8.4 6.4 11.6 13 5.8 0.9 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal Pkinase PF00069.25 EFE38387.1 - 1.9e-63 214.3 0.0 2.4e-63 214.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38387.1 - 1e-34 120.0 0.0 1.4e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE38387.1 - 0.0001 21.3 0.0 0.00015 20.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFE38387.1 - 0.062 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 EFE38387.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EFE38387.1 - 0.15 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFE38387.1 - 0.16 10.9 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain SH2_2 PF14633.6 EFE38388.1 - 3.7e-86 288.0 0.0 3.7e-86 288.0 0.0 2.9 4 0 0 4 4 4 1 SH2 domain HTH_44 PF14641.6 EFE38388.1 - 4e-38 130.4 6.5 1e-36 125.8 0.5 2.8 2 0 0 2 2 2 2 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 EFE38388.1 - 7.1e-28 97.0 0.0 1.6e-27 95.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 EFE38388.1 - 4e-27 94.8 0.0 1.4e-26 93.1 0.0 2.0 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.6 EFE38388.1 - 1.7e-18 67.0 22.2 1.7e-18 67.0 22.2 5.9 6 0 0 6 6 6 1 Acidic N-terminal SPT6 HHH_3 PF12836.7 EFE38388.1 - 1.2e-05 25.5 0.0 3.6e-05 23.9 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_9 PF17674.1 EFE38388.1 - 0.00017 22.4 3.2 0.00017 22.4 3.2 4.4 3 2 1 4 4 4 1 HHH domain SH2 PF00017.24 EFE38388.1 - 0.00027 21.0 0.0 0.0011 19.0 0.0 2.2 2 0 0 2 2 2 1 SH2 domain Tex_YqgF PF16921.5 EFE38388.1 - 0.033 14.6 0.0 0.12 12.9 0.0 2.0 2 0 0 2 2 2 0 Tex protein YqgF-like domain Acetyltransf_3 PF13302.7 EFE38389.1 - 1.9e-22 80.4 0.0 2.5e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE38389.1 - 5.6e-06 26.6 0.1 5.6e-05 23.3 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFE38389.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein TFIIA PF03153.13 EFE38390.1 - 3.2 7.6 15.0 0.97 9.4 9.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit KASH_CCD PF14662.6 EFE38391.1 - 0.00071 19.5 6.7 0.00083 19.2 6.7 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DUF4140 PF13600.6 EFE38391.1 - 0.019 15.4 4.7 0.031 14.7 0.8 2.2 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Spc7 PF08317.11 EFE38391.1 - 0.057 12.3 8.2 0.069 12.0 8.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Rho_Binding PF08912.11 EFE38391.1 - 0.072 13.9 6.0 2.5 9.0 0.4 2.3 2 0 0 2 2 2 0 Rho Binding ABC_tran_CTD PF16326.5 EFE38391.1 - 0.074 13.3 5.0 1.9 8.8 1.7 2.5 1 1 1 2 2 2 0 ABC transporter C-terminal domain Prominin PF05478.11 EFE38391.1 - 0.18 9.8 2.4 0.22 9.4 2.4 1.2 1 0 0 1 1 1 0 Prominin FlxA PF14282.6 EFE38391.1 - 0.22 11.5 6.5 3.4 7.7 6.4 2.1 1 1 0 1 1 1 0 FlxA-like protein PspA_IM30 PF04012.12 EFE38391.1 - 0.24 11.0 7.8 0.063 12.8 3.0 1.9 1 1 1 2 2 2 0 PspA/IM30 family GTP-bdg_M PF16360.5 EFE38391.1 - 0.39 11.3 3.0 1.8 9.2 0.3 2.4 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region HalX PF08663.10 EFE38391.1 - 0.6 10.5 5.3 4.5 7.7 0.4 2.4 1 1 1 2 2 2 0 HalX domain YabA PF06156.13 EFE38391.1 - 0.73 10.5 4.6 4.4 8.0 4.5 2.0 1 1 0 1 1 1 0 Initiation control protein YabA APG6_N PF17675.1 EFE38391.1 - 4.6 7.8 13.2 5.4 7.6 4.0 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region Foie-gras_1 PF11817.8 EFE38392.1 - 0.15 11.7 0.0 0.17 11.4 0.0 1.0 1 0 0 1 1 1 0 Foie gras liver health family 1 Sel1 PF08238.12 EFE38393.1 - 2.8e-16 59.6 19.3 3e-07 30.9 0.1 6.6 7 1 0 7 7 7 4 Sel1 repeat TPR_1 PF00515.28 EFE38393.1 - 0.45 10.4 2.8 0.77 9.7 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Helicase_C_2 PF13307.6 EFE38394.1 - 6.2e-54 182.7 0.0 1.6e-53 181.4 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EFE38394.1 - 5.1e-46 156.5 0.7 2.6e-45 154.2 0.7 2.1 1 1 0 1 1 1 1 DEAD_2 DEAD PF00270.29 EFE38394.1 - 0.0007 19.4 0.0 1 9.1 0.0 2.5 2 1 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 EFE38394.1 - 0.0056 16.7 0.0 1.5 8.8 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFE38394.1 - 0.013 15.7 3.5 0.33 11.2 0.5 3.6 3 1 0 3 3 3 0 AAA domain HBB PF06777.11 EFE38394.1 - 0.057 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Helical and beta-bridge domain MAJIN PF15077.6 EFE38394.1 - 0.067 13.0 1.1 1.2 8.9 2.2 2.2 2 0 0 2 2 2 0 Membrane-anchored junction protein Ribosomal_L27A PF00828.19 EFE38395.1 - 2.3e-22 80.0 0.0 2.9e-22 79.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Hydrolase_4 PF12146.8 EFE38396.1 - 0.013 14.8 0.0 0.85 8.8 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFE38396.1 - 0.12 11.8 0.0 8.4 5.8 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family PLDc PF00614.22 EFE38397.1 - 2e-17 62.6 0.4 4.5e-08 32.9 0.2 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EFE38397.1 - 6e-13 48.8 0.0 6.2e-07 29.4 0.0 3.0 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 EFE38397.1 - 6.9e-10 38.9 0.2 2.2e-09 37.3 0.2 1.9 1 0 0 1 1 1 1 PX domain Dehalogenase PF13486.6 EFE38397.1 - 0.041 13.3 0.1 0.19 11.1 0.1 2.0 2 0 0 2 2 2 0 Reductive dehalogenase subunit AA_permease PF00324.21 EFE38398.1 - 1.1e-45 156.2 21.1 1.9e-39 135.6 18.7 2.4 2 1 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EFE38398.1 - 6.5e-18 64.8 18.9 2.9e-17 62.6 19.3 1.8 1 1 1 2 2 2 1 Amino acid permease Methyltransf_31 PF13847.6 EFE38400.1 - 5.1e-28 97.8 0.1 8.8e-28 97.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38400.1 - 6.1e-19 68.5 0.4 1.5e-18 67.3 0.0 1.9 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE38400.1 - 1.3e-16 61.1 0.2 8.2e-16 58.4 0.0 2.3 3 0 0 3 3 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE38400.1 - 1.2e-15 57.5 0.2 2.6e-15 56.4 0.2 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EFE38400.1 - 1.3e-09 38.1 0.0 2.7e-09 37.1 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EFE38400.1 - 3.5e-09 36.7 0.0 7.4e-09 35.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38400.1 - 1.4e-07 32.1 0.0 2.7e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFE38400.1 - 5.3e-07 29.3 0.6 9.3e-07 28.5 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFE38400.1 - 1.7e-05 24.4 0.1 3.4e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EFE38400.1 - 2.7e-05 24.2 0.0 4.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFE38400.1 - 7.9e-05 22.1 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DOT1 PF08123.13 EFE38400.1 - 0.0015 18.1 1.6 0.0024 17.4 0.6 1.9 2 1 0 2 2 2 1 Histone methylation protein DOT1 UPF0020 PF01170.18 EFE38400.1 - 0.0022 17.7 0.2 0.004 16.9 0.2 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_3 PF01596.17 EFE38400.1 - 0.0056 15.9 0.1 0.012 14.8 0.1 1.6 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_4 PF02390.17 EFE38400.1 - 0.0097 15.4 0.4 0.03 13.8 0.3 1.9 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_18 PF12847.7 EFE38400.1 - 0.02 14.8 0.1 0.04 13.9 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 EFE38400.1 - 0.023 14.3 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase ADH_zinc_N PF00107.26 EFE38400.1 - 0.039 13.9 0.1 0.37 10.8 0.1 2.6 1 1 1 2 2 2 0 Zinc-binding dehydrogenase FtsJ PF01728.19 EFE38400.1 - 0.096 12.8 0.1 0.18 11.9 0.1 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase GCD14 PF08704.10 EFE38400.1 - 0.18 11.4 0.0 2.5 7.7 0.0 2.0 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit bZIP_1 PF00170.21 EFE38401.1 - 0.047 13.8 5.7 0.077 13.1 5.5 1.5 1 1 0 1 1 1 0 bZIP transcription factor Snf7 PF03357.21 EFE38401.1 - 0.049 13.2 0.5 0.076 12.6 0.5 1.2 1 0 0 1 1 1 0 Snf7 RNF111_N PF15303.6 EFE38401.1 - 1.2 8.9 8.5 0.39 10.4 4.8 2.0 1 1 1 2 2 2 0 E3 ubiquitin-protein ligase Arkadia N-terminus Methyltransf_23 PF13489.6 EFE38402.1 - 5.6e-13 49.0 0.0 5.6e-13 49.0 0.0 2.4 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE38402.1 - 1.2e-08 35.5 0.0 2.6e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38402.1 - 2.2e-07 31.5 0.0 5.2e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38402.1 - 9.2e-06 26.3 0.1 4.2e-05 24.2 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38402.1 - 3.9e-05 23.5 1.9 6.7e-05 22.7 0.0 2.3 2 1 0 2 2 1 1 Methyltransferase domain PPP1R26_N PF15740.5 EFE38402.1 - 0.002 16.9 2.9 0.0028 16.4 2.9 1.1 1 0 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 26 N-terminus TFIIA PF03153.13 EFE38402.1 - 0.79 9.7 25.5 1 9.3 25.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4637 PF15470.6 EFE38402.1 - 1.6 8.4 12.6 4.6 7.0 11.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) IER PF05760.12 EFE38402.1 - 1.6 8.9 10.4 2.3 8.5 10.4 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) Paf1 PF03985.13 EFE38402.1 - 1.7 7.6 19.6 2.6 6.9 19.6 1.2 1 0 0 1 1 1 0 Paf1 Macoilin PF09726.9 EFE38402.1 - 1.9 6.9 6.4 2.5 6.5 6.4 1.1 1 0 0 1 1 1 0 Macoilin family Isy1 PF06246.12 EFE38402.1 - 2.4 7.6 11.5 3.6 7.1 11.5 1.2 1 0 0 1 1 1 0 Isy1-like splicing family FAM176 PF14851.6 EFE38402.1 - 6.5 6.4 6.0 11 5.6 6.0 1.4 1 0 0 1 1 1 0 FAM176 family FAD_binding_3 PF01494.19 EFE38403.1 - 2.7e-18 66.3 2.3 3.9e-13 49.4 1.4 2.8 2 1 0 2 2 2 2 FAD binding domain Amino_oxidase PF01593.24 EFE38403.1 - 0.0048 16.2 0.0 0.017 14.5 0.0 1.8 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFE38403.1 - 0.039 14.2 0.1 0.12 12.7 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain MPC PF03650.13 EFE38404.1 - 1.9e-38 131.0 0.1 3.4e-38 130.2 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Enoyl_reductase PF12241.8 EFE38404.1 - 0.1 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region Sel1 PF08238.12 EFE38405.1 - 1.3e-48 162.3 23.9 3.5e-09 37.1 0.1 7.5 7 0 0 7 7 7 7 Sel1 repeat DUF1729 PF08354.10 EFE38406.1 - 1e-161 537.7 0.0 1.7e-161 537.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EFE38406.1 - 3.8e-88 296.1 0.2 5.4e-84 282.4 0.0 4.6 5 1 0 5 5 5 2 Acyl transferase domain FAS_meander PF17951.1 EFE38406.1 - 1.5e-53 180.5 0.0 3.6e-53 179.3 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydratas PF01575.19 EFE38406.1 - 1e-38 131.7 0.1 3.7e-38 129.8 0.0 2.0 2 0 0 2 2 2 1 MaoC like domain SAT PF16073.5 EFE38406.1 - 1e-37 130.2 0.8 3.2e-37 128.5 0.0 2.2 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 EFE38406.1 - 1.9e-37 128.1 0.0 1.2e-36 125.5 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 EFE38406.1 - 1.3e-21 77.1 0.0 3.8e-21 75.6 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase FAS_I_H PF18314.1 EFE38407.1 - 1.8e-76 256.3 0.4 8.2e-76 254.1 0.0 2.2 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 EFE38407.1 - 1.9e-75 252.7 0.2 5e-75 251.3 0.0 1.8 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 EFE38407.1 - 6.4e-21 75.1 0.0 1.2e-20 74.2 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EFE38407.1 - 1.7e-18 66.8 0.1 4e-18 65.6 0.1 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EFE38407.1 - 2.8e-12 46.7 0.0 7.1e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EFE38407.1 - 6.4e-05 22.5 0.0 0.00013 21.5 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE38407.1 - 0.0023 17.5 0.0 0.0066 16.0 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE38407.1 - 0.0033 17.3 0.0 0.0077 16.2 0.0 1.6 1 0 0 1 1 1 1 KR domain S6PP_C PF08472.10 EFE38407.1 - 0.18 11.7 0.0 8.1 6.3 0.0 2.6 2 0 0 2 2 2 0 Sucrose-6-phosphate phosphohydrolase C-terminal TRM PF02005.16 EFE38408.1 - 2.7e-109 365.8 0.0 2.6e-94 316.5 0.0 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_25 PF13649.6 EFE38408.1 - 0.016 15.9 0.0 0.037 14.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EFE38408.1 - 0.031 14.0 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_31 PF13847.6 EFE38408.1 - 0.032 14.0 0.0 0.1 12.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain DUF2067 PF09840.9 EFE38408.1 - 0.1 12.1 0.0 0.28 10.7 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2067) MTS PF05175.14 EFE38408.1 - 0.14 11.6 0.0 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain RRM_1 PF00076.22 EFE38410.1 - 5.1e-13 48.6 0.0 9e-13 47.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EFE38410.1 - 0.0026 17.8 0.1 0.0048 16.9 0.1 1.4 1 0 0 1 1 1 1 Limkain b1 RRM_occluded PF16842.5 EFE38410.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif SOG2 PF10428.9 EFE38410.1 - 4.9 6.2 10.1 5.9 6.0 10.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Pol_alpha_B_N PF08418.10 EFE38410.1 - 9.2 6.2 8.0 13 5.6 8.0 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Kinesin PF00225.23 EFE38412.1 - 5.5e-87 291.8 0.9 5.5e-87 291.8 0.9 2.3 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFE38412.1 - 4.9e-60 201.8 1.8 8.9e-60 200.9 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding AAA_16 PF13191.6 EFE38412.1 - 0.09 13.2 0.0 0.09 13.2 0.0 3.5 2 1 1 3 3 3 0 AAA ATPase domain AAA_24 PF13479.6 EFE38412.1 - 0.14 11.9 1.2 0.61 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain WD40_4 PF16300.5 EFE38413.1 - 4.8e-20 71.2 0.2 1e-19 70.2 0.2 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EFE38413.1 - 8.2e-12 45.5 2.0 0.00041 21.1 0.1 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF1899 PF08953.11 EFE38413.1 - 1.3e-10 40.9 0.0 3.2e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 EFE38413.1 - 3.1e-05 24.2 0.0 0.00095 19.4 0.2 2.7 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE38413.1 - 0.019 13.6 0.2 0.046 12.4 0.2 1.6 1 1 0 1 1 1 0 Nucleoporin Nup120/160 SlyX PF04102.12 EFE38413.1 - 0.022 15.4 0.2 0.048 14.3 0.2 1.6 1 0 0 1 1 1 0 SlyX eIF2A PF08662.11 EFE38413.1 - 0.077 12.9 0.0 0.7 9.7 0.0 2.1 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A COG2 PF06148.11 EFE38413.1 - 0.58 10.2 1.7 1 9.5 1.7 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 FAM76 PF16046.5 EFE38413.1 - 0.75 9.1 3.2 1 8.7 3.2 1.1 1 0 0 1 1 1 0 FAM76 protein CBFD_NFYB_HMF PF00808.23 EFE38415.1 - 3.9e-14 52.7 1.0 6.4e-14 52.0 1.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFE38415.1 - 0.077 13.4 18.1 0.022 15.1 12.9 2.7 2 1 0 2 2 2 0 Core histone H2A/H2B/H3/H4 PAT1 PF09770.9 EFE38415.1 - 0.52 8.5 32.1 0.61 8.3 32.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BTB PF00651.31 EFE38416.1 - 7.4e-06 26.2 0.0 1.4e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TraQ PF09679.10 EFE38417.1 - 0.066 13.1 1.2 0.21 11.5 0.0 2.2 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) Dsh_C PF12316.8 EFE38417.1 - 3 8.2 18.0 3.1 8.2 4.5 2.4 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Peptidase_M20 PF01546.28 EFE38418.1 - 3e-21 76.1 0.0 7.1e-20 71.6 0.0 2.2 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 WD40 PF00400.32 EFE38418.1 - 3.9e-10 40.1 6.4 0.041 14.8 0.0 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat M20_dimer PF07687.14 EFE38418.1 - 0.00024 21.0 0.0 0.00053 19.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain ANAPC4_WD40 PF12894.7 EFE38418.1 - 0.018 15.3 0.0 1.9 8.8 0.0 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain p450 PF00067.22 EFE38419.1 - 1.9e-69 234.6 0.0 2.5e-69 234.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF747 PF05346.11 EFE38420.1 - 3.2e-118 394.8 7.9 4.3e-118 394.4 7.9 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family DUF4834 PF16118.5 EFE38420.1 - 0.45 11.5 0.0 0.45 11.5 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) DUF1189 PF06691.11 EFE38420.1 - 8.5 5.9 11.2 0.34 10.4 3.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1189) KCH PF16944.5 EFE38421.1 - 7.7e-90 301.0 8.1 9.3e-90 300.8 8.1 1.1 1 0 0 1 1 1 1 Fungal potassium channel Sorting_nexin PF03700.13 EFE38421.1 - 0.089 13.3 0.7 0.18 12.3 0.7 1.5 1 0 0 1 1 1 0 Sorting nexin, N-terminal domain Peptidase_M43 PF05572.13 EFE38422.1 - 6.1e-16 58.7 0.2 1.1e-15 57.8 0.2 1.4 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 EFE38422.1 - 8.7e-07 29.5 0.8 5.8e-06 26.8 0.8 2.2 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EFE38422.1 - 4.3e-06 27.0 1.2 1.1e-05 25.7 1.2 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EFE38422.1 - 0.00081 19.1 0.5 0.0077 15.9 0.2 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EFE38422.1 - 0.005 16.7 0.0 0.0094 15.8 0.0 1.4 1 1 0 1 1 1 1 Matrixin Reprolysin_2 PF13574.6 EFE38422.1 - 0.044 13.7 0.2 0.18 11.7 0.4 1.9 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EFE38422.1 - 0.053 12.5 0.1 0.088 11.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 ERG4_ERG24 PF01222.17 EFE38423.1 - 1.3e-144 482.2 17.7 1.6e-144 481.9 17.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family FAD_binding_4 PF01565.23 EFE38424.1 - 3.1e-14 52.9 1.2 2.7e-12 46.6 1.2 2.3 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE38424.1 - 0.0063 16.6 0.2 0.014 15.5 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like YqhR PF11085.8 EFE38425.1 - 0.02 14.8 1.5 0.055 13.4 1.5 1.7 1 0 0 1 1 1 0 Conserved membrane protein YqhR DUF1708 PF08101.11 EFE38426.1 - 1.6e-136 456.0 0.0 2.4e-136 455.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) DUF45 PF01863.17 EFE38426.1 - 0.0077 16.3 1.1 0.015 15.3 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 DUF1708 PF08101.11 EFE38427.1 - 0.063 12.4 0.0 0.081 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) SRF-TF PF00319.18 EFE38428.1 - 1.9e-23 81.7 0.3 2.8e-23 81.1 0.3 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ribosomal_L35Ae PF01247.18 EFE38429.1 - 1.1e-29 102.4 0.5 3.7e-18 65.5 0.1 2.1 2 0 0 2 2 2 2 Ribosomal protein L35Ae SMN PF06003.12 EFE38430.1 - 0.13 11.5 4.9 0.15 11.3 4.9 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF2406 PF10295.9 EFE38431.1 - 6.3e-05 23.6 1.3 0.00051 20.7 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein (DUF2406) Endostatin PF06482.11 EFE38431.1 - 0.1 12.1 1.6 0.12 11.8 1.6 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Gpi16 PF04113.14 EFE38433.1 - 1e-231 770.3 0.0 1.3e-231 769.9 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component LUC7 PF03194.15 EFE38434.1 - 2.1e-65 220.9 2.8 3.3e-65 220.2 0.8 1.8 1 1 1 2 2 2 1 LUC7 N_terminus TelA PF05816.11 EFE38434.1 - 0.0036 16.4 0.5 0.0059 15.7 0.5 1.3 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) DASH_Duo1 PF08651.10 EFE38434.1 - 0.054 13.3 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 DASH complex subunit Duo1 DUF3584 PF12128.8 EFE38434.1 - 0.054 11.0 0.1 0.07 10.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF2130 PF09903.9 EFE38434.1 - 0.075 12.3 0.3 0.13 11.5 0.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) XhlA PF10779.9 EFE38434.1 - 0.092 13.0 1.7 0.31 11.3 0.6 2.1 2 0 0 2 2 2 0 Haemolysin XhlA PP_kinase_N PF13089.6 EFE38434.1 - 0.1 12.9 0.1 0.46 10.8 0.0 1.9 1 1 0 2 2 2 0 Polyphosphate kinase N-terminal domain MCPsignal PF00015.21 EFE38434.1 - 0.17 11.7 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain GRP PF07172.11 EFE38434.1 - 0.34 11.6 20.0 0.57 10.9 20.0 1.3 1 0 0 1 1 1 0 Glycine rich protein family SPOC PF07744.13 EFE38435.1 - 2.2e-25 89.4 0.0 4.5e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 EFE38435.1 - 8.3e-21 74.6 0.4 2.1e-20 73.3 0.0 1.8 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 EFE38435.1 - 7.8e-10 38.5 11.0 1.4e-09 37.7 11.0 1.4 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.6 EFE38435.1 - 0.011 16.0 1.1 0.062 13.7 1.1 2.3 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx PHD_2 PF13831.6 EFE38435.1 - 0.035 13.7 3.5 0.062 12.9 3.5 1.4 1 0 0 1 1 1 0 PHD-finger zinc_ribbon_10 PF10058.9 EFE38435.1 - 1.7 8.4 5.9 3.5 7.4 5.9 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein DASH_Dam1 PF08653.10 EFE38438.1 - 0.15 11.9 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 DASH complex subunit Dam1 FF PF01846.19 EFE38439.1 - 5.8e-13 48.8 7.0 1.5e-09 37.9 0.1 3.8 3 0 0 3 3 3 3 FF domain DUF5641 PF18701.1 EFE38439.1 - 0.0078 16.4 0.8 0.0078 16.4 0.8 2.4 3 0 0 3 3 3 1 Family of unknown function (DUF5641) BPL_N PF09825.9 EFE38439.1 - 0.21 10.6 7.5 0.47 9.5 7.5 1.5 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal WW PF00397.26 EFE38439.1 - 0.29 11.2 6.3 11 6.3 0.1 3.3 2 1 0 2 2 2 0 WW domain PIN_12 PF16289.5 EFE38439.1 - 5.2 7.5 6.7 38 4.7 0.2 2.5 1 1 1 2 2 2 0 PIN domain Proteasome PF00227.26 EFE38440.1 - 9.5e-61 204.6 0.1 1.2e-60 204.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFE38440.1 - 2.6e-13 49.3 0.1 8.7e-13 47.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF5624 PF18538.1 EFE38440.1 - 0.012 15.7 0.3 0.03 14.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) Nitrate_red_gam PF02665.14 EFE38440.1 - 0.023 14.2 0.0 0.033 13.7 0.0 1.1 1 0 0 1 1 1 0 Nitrate reductase gamma subunit MFS_1 PF07690.16 EFE38441.1 - 7.5e-46 156.7 65.4 9.4e-46 156.3 61.5 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE38441.1 - 6.9e-17 61.4 14.5 6.9e-17 61.4 14.5 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFE38441.1 - 2.6e-14 52.6 24.6 6.5e-14 51.3 24.3 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EFE38441.1 - 0.11 10.7 16.6 0.065 11.5 1.5 3.3 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF3522 PF12036.8 EFE38441.1 - 0.88 9.8 7.8 1.4 9.2 4.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3522) PS-DH PF14765.6 EFE38442.1 - 3.6e-64 216.9 0.0 6.1e-64 216.1 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 EFE38442.1 - 6.5e-56 189.7 0.0 1.4e-55 188.6 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EFE38442.1 - 4.1e-55 186.5 0.3 9.7e-55 185.3 0.3 1.7 1 0 0 1 1 1 1 KR domain Beta-lactamase PF00144.24 EFE38442.1 - 5.8e-41 140.8 0.0 1e-40 140.0 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase Acyl_transf_1 PF00698.21 EFE38442.1 - 2e-37 129.4 0.0 4e-37 128.4 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFE38442.1 - 2.7e-31 108.0 0.3 1.6e-30 105.6 0.0 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EFE38442.1 - 6.2e-19 68.6 0.0 2.6e-18 66.6 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EFE38442.1 - 1.8e-17 64.7 0.0 6.7e-15 56.3 0.0 3.4 3 0 0 3 3 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFE38442.1 - 1.3e-12 47.8 0.0 3.5e-11 43.2 0.0 3.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EFE38442.1 - 8.1e-12 45.0 1.1 7.7e-11 41.8 0.2 2.4 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_23 PF13489.6 EFE38442.1 - 1.3e-11 44.6 0.0 5.8e-11 42.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38442.1 - 1.2e-10 42.0 0.0 1.4e-09 38.5 0.0 3.0 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38442.1 - 1.5e-10 41.1 0.0 4.6e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE38442.1 - 2.2e-09 37.8 0.0 1.4e-08 35.3 0.0 2.6 2 0 0 2 2 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EFE38442.1 - 2.6e-08 33.7 0.3 7e-08 32.3 0.3 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ubie_methyltran PF01209.18 EFE38442.1 - 4e-05 23.1 0.0 0.00012 21.5 0.0 1.7 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.25 EFE38442.1 - 0.00018 21.8 0.0 0.00069 19.9 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.12 EFE38442.1 - 0.0032 17.3 0.0 0.0072 16.2 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EFE38442.1 - 0.012 15.0 0.0 0.03 13.7 0.0 1.6 1 0 0 1 1 1 0 Thiolase, N-terminal domain Peptidase_S11 PF00768.20 EFE38442.1 - 0.042 13.3 0.0 0.1 12.0 0.0 1.6 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Methyltransf_16 PF10294.9 EFE38442.1 - 0.083 12.6 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Lysine methyltransferase Beta-lactamase2 PF13354.6 EFE38442.1 - 0.13 11.9 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 Beta-lactamase enzyme family AIF_C PF14721.6 EFE38443.1 - 0.55 10.6 3.2 0.51 10.7 0.1 2.0 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SHE3 PF17078.5 EFE38443.1 - 0.92 9.2 11.7 0.2 11.4 3.0 2.1 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 NUDIX PF00293.28 EFE38444.1 - 1.6e-17 63.7 0.2 1.6e-17 63.7 0.2 1.9 2 0 0 2 2 2 1 NUDIX domain Tim54 PF11711.8 EFE38444.1 - 0.16 10.8 5.8 0.25 10.1 5.8 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RNA_pol_A_bac PF01000.26 EFE38445.1 - 1.7e-30 105.6 0.0 2.6e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFE38445.1 - 2.1e-14 52.7 0.0 2.7e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Baculo_PEP_C PF04513.12 EFE38446.1 - 0.061 13.4 4.7 0.94 9.5 0.3 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cytochrom_C PF00034.21 EFE38447.1 - 1.2e-09 39.2 0.3 2.5e-09 38.1 0.1 1.7 2 1 0 2 2 2 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EFE38447.1 - 6e-07 29.7 1.2 2.8e-06 27.5 1.2 2.1 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III CCP_MauG PF03150.14 EFE38447.1 - 0.04 14.6 0.0 0.061 14.0 0.0 1.4 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase BPS1 PF05633.11 EFE38447.1 - 0.069 12.2 0.0 0.093 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein BYPASS1-related Cytochrom_C550 PF14495.6 EFE38447.1 - 0.13 12.0 0.1 0.62 9.8 0.0 2.0 2 0 0 2 2 2 0 Cytochrome c-550 domain RNase_PH PF01138.21 EFE38449.1 - 1.2e-12 48.5 0.0 3.8e-12 46.9 0.0 1.9 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 NIR_SIR_ferr PF03460.17 EFE38450.1 - 0.082 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Nitrite/Sulfite reductase ferredoxin-like half domain Metallophos PF00149.28 EFE38451.1 - 9.7e-12 45.8 0.3 1.2e-11 45.6 0.3 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Inv-AAD PF18785.1 EFE38452.1 - 3.2e-47 159.6 0.1 4.7e-47 159.1 0.1 1.2 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 EFE38452.1 - 3.9e-09 36.3 0.1 3.9e-08 33.1 0.0 2.4 2 1 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 EFE38452.1 - 2.3e-06 27.6 0.0 2.9e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain SNAD4 PF18750.1 EFE38452.1 - 0.049 13.8 0.0 0.097 12.8 0.0 1.6 1 1 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 Stn1 PF10451.9 EFE38453.1 - 3.6e-13 49.1 0.2 4.7e-09 35.6 0.0 2.1 2 0 0 2 2 2 2 Telomere regulation protein Stn1 LMBR1 PF04791.16 EFE38453.1 - 0.27 10.1 0.4 0.28 10.0 0.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Vma12 PF11712.8 EFE38453.1 - 2.8 8.0 5.0 5.2 7.1 5.0 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SelP_N PF04592.14 EFE38454.1 - 2.1 7.7 14.1 3.6 6.9 14.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Abhydrolase_1 PF00561.20 EFE38455.1 - 1.3e-16 61.0 0.0 2.3e-15 57.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE38455.1 - 1.8e-08 35.3 0.3 2.5e-08 34.8 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFE38455.1 - 0.00047 19.5 0.0 0.0035 16.6 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 F-box-like PF12937.7 EFE38457.1 - 0.0027 17.6 0.1 0.0071 16.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like APH PF01636.23 EFE38458.1 - 8.1e-11 42.3 0.0 7.3e-10 39.2 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFE38458.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Stc1 PF12898.7 EFE38459.1 - 2.4e-17 63.3 10.8 2.4e-17 63.3 10.8 1.9 2 0 0 2 2 2 1 Stc1 domain DUF5448 PF17526.2 EFE38459.1 - 0.027 14.7 0.0 0.052 13.7 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5448) Sda PF08970.10 EFE38461.1 - 0.075 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Sporulation inhibitor A FAD_binding_2 PF00890.24 EFE38463.1 - 1.4e-62 212.2 0.1 2.2e-62 211.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 EFE38463.1 - 7.2e-21 74.1 0.1 5.5e-20 71.3 0.1 2.4 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain WD40 PF00400.32 EFE38465.1 - 2.5e-13 50.3 2.9 0.13 13.2 0.2 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE38465.1 - 0.0043 17.3 0.1 4.1 7.8 0.0 3.6 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain TFIIF_alpha PF05793.12 EFE38465.1 - 0.54 8.8 3.0 0.89 8.1 3.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MFS_1 PF07690.16 EFE38466.1 - 8.7e-27 94.0 42.4 8.7e-27 94.0 42.4 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily ketoacyl-synt PF00109.26 EFE38467.1 - 2.9e-80 269.5 0.1 7e-80 268.2 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFE38467.1 - 1.8e-64 218.3 0.0 3.4e-64 217.4 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFE38467.1 - 5.6e-63 212.1 0.0 5.1e-62 209.0 0.0 2.4 2 0 0 2 2 2 1 KR domain Ketoacyl-synt_C PF02801.22 EFE38467.1 - 7.7e-42 142.0 0.5 1.9e-41 140.8 0.5 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EFE38467.1 - 1.9e-15 57.3 0.0 5.3e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EFE38467.1 - 2e-13 50.5 0.1 2.2e-12 47.1 0.0 2.5 2 0 0 2 2 2 1 Phosphopantetheine attachment site PS-DH PF14765.6 EFE38467.1 - 2.2e-08 33.7 0.0 3.8e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.25 EFE38467.1 - 6e-06 25.8 0.0 8.8e-05 22.0 0.0 2.8 2 1 0 2 2 2 1 short chain dehydrogenase Thiolase_N PF00108.23 EFE38467.1 - 3.8e-05 23.2 3.0 6.9e-05 22.3 0.8 2.4 3 0 0 3 3 3 1 Thiolase, N-terminal domain CENP-B_dimeris PF09026.10 EFE38468.1 - 0.0038 17.6 12.9 0.0052 17.1 12.9 1.2 1 0 0 1 1 1 1 Centromere protein B dimerisation domain FAM176 PF14851.6 EFE38468.1 - 0.021 14.5 1.0 0.03 14.0 1.0 1.3 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 EFE38468.1 - 0.027 14.5 2.2 0.033 14.2 2.2 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 EFE38468.1 - 0.045 13.5 9.4 0.061 13.0 9.4 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 EFE38468.1 - 0.055 11.6 7.3 0.062 11.4 7.3 1.0 1 0 0 1 1 1 0 DNA polymerase phi SIN1 PF05422.12 EFE38468.1 - 0.086 13.4 4.2 0.12 12.9 4.2 1.2 1 0 0 1 1 1 0 Stress-activated map kinase interacting protein 1 (SIN1) Med13_C PF06333.12 EFE38468.1 - 0.12 11.6 2.8 0.11 11.8 2.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Pox_Ag35 PF03286.14 EFE38468.1 - 0.13 12.1 3.2 0.17 11.7 3.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein GCIP PF13324.6 EFE38468.1 - 0.27 10.8 1.7 0.29 10.7 1.7 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting PBP1_TM PF14812.6 EFE38468.1 - 0.65 10.4 11.8 1.3 9.5 11.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tom22 PF04281.13 EFE38468.1 - 0.87 9.4 5.4 6.2 6.6 5.5 1.9 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 RRN3 PF05327.11 EFE38468.1 - 0.94 7.9 2.7 1 7.8 2.7 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sigma70_ner PF04546.13 EFE38468.1 - 1.2 9.0 5.1 1.6 8.6 5.1 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF4611 PF15387.6 EFE38468.1 - 2.2 8.6 10.7 3.8 7.8 10.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) NOA36 PF06524.12 EFE38468.1 - 2.6 7.3 14.4 3.4 6.9 14.4 1.1 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EFE38468.1 - 2.6 6.2 4.5 3.1 6.0 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein BNIP3 PF06553.12 EFE38468.1 - 3.8 7.1 6.8 5.4 6.6 6.8 1.2 1 0 0 1 1 1 0 BNIP3 RasGEF PF00617.19 EFE38469.1 - 1.6e-60 204.3 0.1 2.8e-60 203.6 0.1 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFE38469.1 - 6.9e-26 90.5 0.1 1.6e-25 89.3 0.1 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EFE38469.1 - 2.9e-09 36.4 0.5 5.7e-09 35.4 0.5 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFE38469.1 - 3e-08 33.2 0.0 8.1e-08 31.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EFE38469.1 - 7.2e-08 32.2 0.2 1.7e-07 31.0 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 EFE38469.1 - 0.00044 20.3 1.5 0.021 14.9 0.0 2.7 2 0 0 2 2 2 1 WW domain RHH_1 PF01402.21 EFE38469.1 - 0.057 13.4 0.7 0.21 11.6 0.7 2.0 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family SH3_1 PF00018.28 EFE38470.1 - 2.1e-11 43.3 0.0 3.7e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE38470.1 - 3.9e-09 36.2 0.0 8.1e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFE38470.1 - 2.6e-07 30.2 0.0 4.8e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain ENTH PF01417.20 EFE38471.1 - 6.7e-06 26.2 0.3 1.7e-05 24.8 0.0 1.8 2 0 0 2 2 2 1 ENTH domain RasGAP PF00616.19 EFE38472.1 - 9.2e-52 175.8 0.0 2.2e-51 174.6 0.0 1.6 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EFE38472.1 - 1.7e-50 170.7 4.7 7.4e-50 168.7 4.7 2.2 1 0 0 1 1 1 1 RasGAP C-terminus CH PF00307.31 EFE38472.1 - 2.4e-13 50.2 0.0 1.6e-12 47.6 0.0 2.3 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.27 EFE38472.1 - 8.5e-08 31.3 51.8 0.19 11.6 0.0 15.4 17 1 1 18 18 18 4 IQ calmodulin-binding motif CAMSAP_CH PF11971.8 EFE38472.1 - 0.028 14.2 0.0 0.14 12.0 0.0 2.2 2 0 0 2 2 2 0 CAMSAP CH domain IZUMO PF15005.6 EFE38472.1 - 0.076 13.5 0.1 0.36 11.3 0.1 2.3 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Trypan_PARP PF05887.11 EFE38472.1 - 0.079 12.9 4.9 0.17 11.9 4.9 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF1033 PF06279.11 EFE38472.1 - 0.092 12.9 0.4 1.1 9.5 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1033) Acylphosphatase PF00708.18 EFE38472.1 - 0.099 13.1 1.1 20 5.7 0.1 3.0 2 0 0 2 2 2 0 Acylphosphatase MbeB_N PF04837.12 EFE38472.1 - 7.9 6.9 6.0 76 3.7 0.2 3.7 3 0 0 3 3 3 0 MbeB-like, N-term conserved region IMPDH PF00478.25 EFE38473.1 - 1.2e-124 415.8 5.1 1.5e-124 415.5 5.1 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EFE38473.1 - 5.8e-16 58.7 0.1 1.4e-09 38.2 0.0 2.7 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 EFE38473.1 - 1e-07 31.3 1.1 2.3e-07 30.2 0.9 1.6 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 EFE38473.1 - 1.9e-06 27.5 7.7 0.0025 17.2 6.3 3.0 2 1 1 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 EFE38473.1 - 0.0001 21.8 2.3 0.00032 20.2 2.3 1.7 1 1 0 1 1 1 1 Histidine biosynthesis protein PK PF00224.21 EFE38473.1 - 0.0014 17.6 0.0 0.0028 16.6 0.0 1.5 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain Aldolase PF01081.19 EFE38473.1 - 0.012 15.1 1.5 0.066 12.6 0.2 2.3 1 1 0 2 2 2 0 KDPG and KHG aldolase ThiG PF05690.14 EFE38473.1 - 0.032 13.5 0.5 0.032 13.5 0.5 1.7 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG YpsA PF06908.11 EFE38473.1 - 0.033 14.2 0.0 0.059 13.4 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family Glu_synthase PF01645.17 EFE38473.1 - 0.056 12.6 3.3 0.1 11.7 3.3 1.4 1 0 0 1 1 1 0 Conserved region in glutamate synthase EAL PF00563.20 EFE38473.1 - 0.17 11.4 0.5 18 4.8 0.0 2.5 2 1 0 2 2 2 0 EAL domain G3P_antiterm PF04309.12 EFE38473.1 - 0.31 10.4 2.0 2.8 7.3 0.2 2.5 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Ribosomal_S21e PF01249.18 EFE38475.1 - 1.3e-30 105.3 0.3 3e-30 104.2 0.3 1.5 1 1 0 1 1 1 1 Ribosomal protein S21e Scm3 PF10384.9 EFE38475.1 - 0.084 12.6 0.1 0.23 11.2 0.0 1.8 2 0 0 2 2 2 0 Centromere protein Scm3 tRNA-synt_2d PF01409.20 EFE38476.1 - 2.3e-88 295.8 0.0 3.1e-88 295.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EFE38476.1 - 1.3e-16 60.6 0.5 1.3e-16 60.6 0.5 2.0 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA-synt_2 PF00152.20 EFE38476.1 - 6.1e-05 22.3 0.1 0.0033 16.6 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA_synthFbeta PF17759.1 EFE38476.1 - 6.8e-05 22.4 0.0 0.044 13.2 0.0 2.4 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD2 PF18554.1 EFE38476.1 - 0.00053 19.9 0.5 0.0014 18.5 0.5 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 2 DUF2564 PF10819.8 EFE38476.1 - 0.03 14.7 0.1 0.076 13.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2564) LRRC37 PF15779.5 EFE38476.1 - 0.065 13.6 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 Leucine-rich repeat-containing protein 37 family Fez1 PF06818.15 EFE38477.1 - 0.0096 16.4 0.0 0.016 15.7 0.0 1.4 1 0 0 1 1 1 1 Fez1 Kdo PF06293.14 EFE38478.1 - 0.00039 19.8 0.1 0.00072 19.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE38478.1 - 0.0017 18.3 0.2 0.0017 18.3 0.2 2.7 3 1 1 4 4 4 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFE38478.1 - 0.088 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 EFE38478.1 - 0.14 11.8 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase PF00069.25 EFE38478.1 - 0.18 11.1 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain DUF3886 PF13025.6 EFE38478.1 - 0.73 10.1 9.3 2 8.7 9.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Autophagy_N PF03986.13 EFE38479.1 - 4.5e-45 153.0 1.9 5.3e-45 152.7 0.0 1.8 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 EFE38479.1 - 1.3e-15 56.5 0.5 2.3e-15 55.8 0.5 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 EFE38479.1 - 4.5e-14 52.8 0.1 7.6e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain TFIIB PF00382.19 EFE38480.1 - 0.01 15.9 0.0 0.048 13.7 0.0 2.1 3 0 0 3 3 3 0 Transcription factor TFIIB repeat EST1_DNA_bind PF10373.9 EFE38481.1 - 9.2e-11 41.7 2.7 1.8e-08 34.2 1.9 2.4 2 0 0 2 2 2 2 Est1 DNA/RNA binding domain 5_nucleotid PF05761.14 EFE38481.1 - 0.029 13.3 0.4 0.058 12.3 0.4 1.4 1 0 0 1 1 1 0 5' nucleotidase family TFIIA PF03153.13 EFE38481.1 - 4 7.3 29.3 1.2 9.0 5.1 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit LAP1C PF05609.12 EFE38482.1 - 0.15 11.1 11.7 0.24 10.5 11.7 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 EFE38482.1 - 0.27 9.5 12.6 0.41 8.9 12.6 1.2 1 0 0 1 1 1 0 CDC45-like protein eIF-3c_N PF05470.12 EFE38482.1 - 1 7.6 4.2 1.7 6.8 4.2 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CobT PF06213.12 EFE38482.1 - 3.9 6.8 17.5 7.1 5.9 17.5 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFB6 PF17110.5 EFE38482.1 - 5.3 6.8 6.1 12 5.6 6.1 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH NUDIX PF00293.28 EFE38483.1 - 2.4e-09 37.3 0.0 4e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX PF00293.28 EFE38484.1 - 3.9e-14 52.8 0.0 4.3e-14 52.7 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain KH_1 PF00013.29 EFE38485.1 - 4.8e-41 138.4 9.0 6.6e-17 61.1 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EFE38485.1 - 2.2e-09 37.0 9.6 0.0017 18.2 0.6 3.4 3 1 0 3 3 3 3 KH domain KH_4 PF13083.6 EFE38485.1 - 3.2e-09 36.5 2.7 0.026 14.4 0.2 3.5 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EFE38485.1 - 0.001 19.1 6.8 0.3 11.2 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain ECF-ribofla_trS PF07155.12 EFE38485.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 ECF-type riboflavin transporter, S component Epimerase PF01370.21 EFE38486.1 - 3.2e-17 62.8 0.0 4.7e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFE38486.1 - 2.5e-14 53.0 0.0 3.3e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFE38486.1 - 3.3e-09 36.6 0.0 6.1e-09 35.7 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFE38486.1 - 4.3e-08 32.7 0.0 9.2e-08 31.6 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EFE38486.1 - 3.5e-07 30.3 0.0 8.4e-07 29.1 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 EFE38486.1 - 8.4e-07 29.1 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFE38486.1 - 0.0015 17.7 0.0 0.002 17.3 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EFE38486.1 - 0.0019 17.7 0.3 0.0037 16.8 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase NmrA PF05368.13 EFE38486.1 - 0.0022 17.6 0.2 0.0071 15.9 0.2 1.9 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 EFE38486.1 - 0.015 14.4 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain DSBA PF01323.20 EFE38487.1 - 1e-23 84.1 0.0 1.1e-23 84.0 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 EFE38487.1 - 0.05 13.8 0.0 0.075 13.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Pkinase PF00069.25 EFE38488.1 - 7.9e-20 71.3 0.0 4.3e-19 68.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38488.1 - 0.00013 21.3 0.0 0.025 13.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase CAF1A PF12253.8 EFE38489.1 - 0.0091 16.1 0.6 0.018 15.2 0.6 1.5 1 0 0 1 1 1 1 Chromatin assembly factor 1 subunit A Lipoprotein_18 PF06804.11 EFE38490.1 - 0.19 10.8 0.7 0.26 10.3 0.7 1.1 1 0 0 1 1 1 0 NlpB/DapX lipoprotein DUF4637 PF15470.6 EFE38492.1 - 0.21 11.3 11.9 0.023 14.5 6.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) DNA_pol_phi PF04931.13 EFE38492.1 - 0.54 8.3 8.0 0.73 7.9 8.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 EFE38492.1 - 0.78 9.5 10.9 0.18 11.6 7.4 1.7 2 0 0 2 2 2 0 Pox virus Ag35 surface protein OAD_gamma PF04277.13 EFE38492.1 - 3.2 8.4 5.3 7.5 7.2 5.3 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain CobT PF06213.12 EFE38492.1 - 7.3 5.9 19.0 0.44 9.9 9.7 2.3 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT T4bSS_IcmS PF12608.8 EFE38493.1 - 0.13 12.6 0.2 0.15 12.4 0.2 1.1 1 0 0 1 1 1 0 Type IVb secretion, IcmS, effector-recruitment DUF1700 PF08006.11 EFE38494.1 - 0.22 11.1 8.2 0.28 10.7 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) ABC2_membrane_3 PF12698.7 EFE38494.1 - 0.23 10.5 20.2 0.31 10.1 20.2 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein RseC_MucC PF04246.12 EFE38494.1 - 6.7 6.7 5.8 6.6 6.7 5.2 1.4 1 1 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC PGA2 PF07543.12 EFE38495.1 - 1.2 9.1 8.4 1.7 8.7 8.4 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DSPc PF00782.20 EFE38496.1 - 9.5e-25 87.0 0.0 1.9e-21 76.2 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFE38496.1 - 0.079 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Beta-lactamase PF00144.24 EFE38497.1 - 2.4e-41 142.1 0.0 4.3e-41 141.2 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 EFE38497.1 - 6.9e-09 36.1 0.1 1.4e-08 35.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) FAM176 PF14851.6 EFE38497.1 - 0.59 9.8 2.3 2.9 7.6 1.2 2.1 2 0 0 2 2 2 0 FAM176 family Spt5_N PF11942.8 EFE38497.1 - 3.8 8.6 12.4 1.2 10.2 7.8 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal ABC_membrane PF00664.23 EFE38498.1 - 5.2e-100 334.6 40.0 2.6e-55 188.0 15.8 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE38498.1 - 9.7e-71 236.7 0.0 1.6e-34 119.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFE38498.1 - 2.5e-16 59.8 5.0 5e-05 22.8 0.0 4.5 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFE38498.1 - 5e-10 40.0 6.3 0.00091 19.6 2.2 3.7 3 1 0 3 3 2 2 AAA ATPase domain AAA_15 PF13175.6 EFE38498.1 - 6.2e-08 32.7 0.0 0.0076 16.0 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 EFE38498.1 - 6.9e-08 31.7 0.5 0.0076 15.1 0.0 2.5 2 0 0 2 2 2 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EFE38498.1 - 2.6e-07 30.7 0.0 0.015 15.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EFE38498.1 - 3.2e-07 30.4 0.7 0.0067 16.3 0.0 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFE38498.1 - 4.1e-07 29.6 0.2 0.023 14.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EFE38498.1 - 3e-06 26.7 0.1 0.14 11.4 0.0 3.2 3 0 0 3 3 3 2 Zeta toxin AAA_22 PF13401.6 EFE38498.1 - 4.5e-06 27.0 0.8 0.021 15.1 0.1 3.8 2 2 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFE38498.1 - 3.6e-05 23.8 0.4 0.37 10.8 0.0 4.0 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EFE38498.1 - 0.00012 21.9 1.8 0.1 12.3 0.0 3.4 4 0 0 4 4 3 1 AAA domain AAA PF00004.29 EFE38498.1 - 0.00035 21.0 1.1 23 5.4 0.4 4.3 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFE38498.1 - 0.0011 18.5 0.0 0.96 8.9 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 EFE38498.1 - 0.0012 19.4 0.0 0.1 13.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EFE38498.1 - 0.0012 19.0 4.1 2.2 8.6 0.5 3.8 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 EFE38498.1 - 0.0013 18.0 0.0 0.5 9.5 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_23 PF13476.6 EFE38498.1 - 0.0016 19.0 0.0 2.7 8.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EFE38498.1 - 0.0027 17.9 0.0 0.49 10.5 0.0 3.0 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EFE38498.1 - 0.0051 16.0 0.0 1.1 8.4 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) PRK PF00485.18 EFE38498.1 - 0.0052 16.5 0.0 0.39 10.4 0.0 2.3 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_25 PF13481.6 EFE38498.1 - 0.0054 16.3 0.0 5.2 6.6 0.1 2.8 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFE38498.1 - 0.0077 16.3 0.4 1.2 9.3 0.0 3.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase Rad17 PF03215.15 EFE38498.1 - 0.01 15.8 0.0 1.6 8.6 0.0 3.0 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_24 PF13479.6 EFE38498.1 - 0.019 14.7 0.1 0.51 10.0 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_28 PF13521.6 EFE38498.1 - 0.02 15.1 0.2 3.7 7.8 0.0 2.9 3 0 0 3 3 2 0 AAA domain MeaB PF03308.16 EFE38498.1 - 0.039 12.9 0.1 0.19 10.7 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 EFE38498.1 - 0.044 13.7 0.0 2.4 8.0 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase RNA_helicase PF00910.22 EFE38498.1 - 0.072 13.5 0.1 10 6.6 0.0 3.0 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.17 EFE38498.1 - 0.073 13.2 0.1 16 5.5 0.0 3.0 3 0 0 3 3 2 0 Helicase HerA, central domain ECH_2 PF16113.5 EFE38498.1 - 0.12 11.8 0.2 0.9 9.0 0.0 2.1 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase TniB PF05621.11 EFE38498.1 - 0.23 10.9 2.1 43 3.5 0.0 4.4 6 0 0 6 6 6 0 Bacterial TniB protein Methyltrn_RNA_2 PF04013.12 EFE38498.1 - 0.24 11.1 1.3 0.37 10.5 0.2 1.8 2 0 0 2 2 2 0 Putative SAM-dependent RNA methyltransferase AMP-binding PF00501.28 EFE38499.1 - 1.7e-132 442.0 0.0 3.1e-66 223.7 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EFE38499.1 - 2.7e-113 379.1 0.0 5.5e-35 120.9 0.0 5.8 5 1 0 5 5 5 5 Condensation domain PP-binding PF00550.25 EFE38499.1 - 5.4e-35 119.6 0.2 4.3e-12 46.2 0.0 3.7 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE38499.1 - 0.0011 19.8 0.0 3.6 8.6 0.0 2.9 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain HpaB PF03241.13 EFE38499.1 - 0.009 15.1 0.0 0.069 12.2 0.0 2.1 2 0 0 2 2 2 1 4-hydroxyphenylacetate 3-hydroxylase C terminal Cyclophil_like2 PF18050.1 EFE38499.1 - 0.024 14.6 0.2 1.4 8.9 0.0 2.9 3 0 0 3 3 3 0 Cyclophilin-like family Methyltransf_31 PF13847.6 EFE38500.1 - 2.2e-13 50.2 0.0 1.8e-12 47.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE38500.1 - 3.9e-06 26.8 0.0 5.6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38500.1 - 5e-06 27.1 0.1 0.00012 22.7 0.1 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE38500.1 - 0.00016 22.3 0.1 0.0059 17.2 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.12 EFE38500.1 - 0.0049 16.5 0.1 0.009 15.6 0.1 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.12 EFE38500.1 - 0.019 15.7 1.2 0.091 13.5 0.1 2.4 2 1 0 2 2 2 0 Methyltransferase domain CENP-B_dimeris PF09026.10 EFE38500.1 - 0.026 14.9 5.9 0.051 14.0 5.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EFE38500.1 - 0.37 10.4 1.8 0.61 9.7 1.8 1.3 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 EFE38500.1 - 2.6 7.3 7.7 4 6.7 7.7 1.2 1 0 0 1 1 1 0 NOA36 protein Methyltransf_16 PF10294.9 EFE38501.1 - 1.3e-06 28.2 0.0 8.8e-05 22.3 0.0 2.2 1 1 0 1 1 1 1 Lysine methyltransferase zf-C2H2 PF00096.26 EFE38502.1 - 0.015 15.7 3.7 0.047 14.2 3.7 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE38502.1 - 0.68 10.9 3.3 2.2 9.3 3.3 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger ING PF12998.7 EFE38503.1 - 3.1e-07 30.9 0.0 6.7e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Collagen PF01391.18 EFE38504.1 - 0.023 14.4 4.4 0.057 13.2 4.4 1.6 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) BAG PF02179.16 EFE38505.1 - 1.1e-09 38.5 0.1 2.8e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 BAG domain IMUP PF15761.5 EFE38505.1 - 0.12 13.1 14.9 2 9.1 3.5 2.5 2 0 0 2 2 2 0 Immortalisation up-regulated protein SUIM_assoc PF16619.5 EFE38505.1 - 1.2 9.3 24.1 0.095 12.8 7.0 3.2 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF4710 PF15828.5 EFE38506.1 - 0.21 11.7 12.5 0.23 11.6 12.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) RNA_polI_A34 PF08208.11 EFE38506.1 - 1.1 9.3 15.1 1.1 9.3 15.1 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 TMEM208_SND2 PF05620.11 EFE38506.1 - 1.2 8.9 7.2 1.1 9.0 7.2 1.0 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Cnd2 PF05786.14 EFE38506.1 - 1.7 7.2 14.2 2 7.0 14.2 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 Ferlin_C PF16165.5 EFE38506.1 - 4 7.4 10.8 3.6 7.5 10.8 1.0 1 0 0 1 1 1 0 Ferlin C-terminus FAM176 PF14851.6 EFE38506.1 - 4.2 7.0 7.9 4.1 7.1 7.9 1.0 1 0 0 1 1 1 0 FAM176 family Cadherin_tail PF15974.5 EFE38506.1 - 5.2 7.4 9.6 5.5 7.3 9.6 1.0 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region LMBR1 PF04791.16 EFE38507.1 - 1e-84 285.3 0.0 1.2e-84 285.1 0.0 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Ribosomal_60s PF00428.19 EFE38507.1 - 0.0027 18.3 3.1 0.0027 18.3 3.1 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein AgrB PF04647.15 EFE38508.1 - 0.0015 17.9 0.1 0.002 17.5 0.1 1.1 1 0 0 1 1 1 1 Accessory gene regulator B DUF5316 PF17247.2 EFE38508.1 - 0.06 13.4 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5316) ETRAMP PF09716.10 EFE38508.1 - 0.089 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Med15_fungi PF05397.12 EFE38509.1 - 5.8e-24 84.5 0.0 5.8e-24 84.5 0.0 7.5 9 0 0 9 9 9 1 Mediator complex subunit 15 EamA PF00892.20 EFE38510.1 - 8.8e-09 35.6 26.7 1.5e-05 25.2 2.7 2.7 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EFE38510.1 - 2e-08 33.8 0.2 3.4e-08 33.0 0.2 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EFE38510.1 - 0.00035 19.9 7.6 0.00035 19.9 7.6 1.7 2 0 0 2 2 2 1 UAA transporter family TPT PF03151.16 EFE38510.1 - 0.0024 17.2 0.4 0.0024 17.2 0.4 2.2 2 0 0 2 2 2 1 Triose-phosphate Transporter family MBOAT PF03062.19 EFE38511.1 - 4.8e-30 105.1 16.1 4e-29 102.1 10.3 2.0 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family DUF3328 PF11807.8 EFE38511.1 - 9.3 6.0 7.0 0.82 9.4 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3328) Adaptin_N PF01602.20 EFE38512.1 - 4.2e-141 471.1 0.3 5e-141 470.8 0.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EFE38512.1 - 3.8e-15 56.1 0.1 1.1e-14 54.7 0.1 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EFE38512.1 - 2.9e-09 37.2 1.5 9.4e-05 22.5 0.0 4.0 2 2 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFE38512.1 - 1.2e-08 35.2 0.5 0.0089 16.4 0.0 4.4 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 EFE38512.1 - 0.00037 20.5 2.1 6.5 7.3 0.1 4.6 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 EFE38512.1 - 0.0038 17.7 0.2 22 5.7 0.0 4.8 4 1 0 4 4 4 0 HEAT-like repeat Arm PF00514.23 EFE38512.1 - 0.032 14.3 0.1 99 3.2 0.1 5.2 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat RICTOR_M PF14666.6 EFE38512.1 - 0.066 13.0 0.4 0.43 10.4 0.0 2.5 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain Cohesin_HEAT PF12765.7 EFE38512.1 - 0.16 12.3 0.2 0.56 10.6 0.2 2.0 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion MFS_1 PF07690.16 EFE38515.1 - 2e-34 119.1 27.0 2.3e-34 118.9 27.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE38515.1 - 1.7e-09 37.1 3.6 1.7e-09 37.1 3.6 1.7 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFE38515.1 - 5.6e-05 21.8 1.4 8.9e-05 21.1 1.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EFE38515.1 - 0.073 11.4 4.1 0.026 12.9 0.3 1.9 2 0 0 2 2 2 0 Transmembrane secretion effector UQ_con PF00179.26 EFE38516.1 - 5.6e-20 71.4 0.2 1.5e-19 70.0 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFE38516.1 - 0.0017 18.1 0.0 0.0084 15.8 0.0 1.9 2 0 0 2 2 2 1 Prokaryotic E2 family B MKT1_C PF12246.8 EFE38517.1 - 1.3e-77 260.3 0.0 1.9e-77 259.7 0.0 1.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EFE38517.1 - 8e-31 106.3 0.0 1.8e-30 105.1 0.0 1.6 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.18 EFE38517.1 - 0.0017 18.7 0.0 0.0041 17.4 0.0 1.6 1 0 0 1 1 1 1 XPG I-region GIT_SHD PF08518.11 EFE38517.1 - 0.052 13.2 0.2 0.052 13.2 0.2 2.0 2 0 0 2 2 2 0 Spa2 homology domain (SHD) of GIT DIOX_N PF14226.6 EFE38518.1 - 2.1e-13 51.0 0.3 1.9e-06 28.6 0.1 2.0 1 1 1 2 2 2 2 non-haem dioxygenase in morphine synthesis N-terminal zf-MYND PF01753.18 EFE38519.1 - 6.7e-08 32.5 20.7 1.7e-07 31.2 20.7 1.7 1 0 0 1 1 1 1 MYND finger KAAG1 PF15354.6 EFE38520.1 - 0.001 19.5 2.5 0.0018 18.8 1.1 2.1 2 1 1 3 3 3 1 Kidney-associated antigen 1 ATG27 PF09451.10 EFE38521.1 - 4.5e-46 157.8 0.1 5.7e-46 157.5 0.1 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EFE38521.1 - 0.00034 20.7 0.1 0.28 11.3 0.1 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat SRP9-21 PF05486.12 EFE38521.1 - 0.14 12.6 2.6 0.25 11.7 2.6 1.4 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) Prefoldin_2 PF01920.20 EFE38522.1 - 1.2e-22 79.8 3.9 1.6e-22 79.4 3.9 1.1 1 0 0 1 1 1 1 Prefoldin subunit Osmo_CC PF08946.10 EFE38522.1 - 0.036 14.3 2.6 0.098 12.9 2.6 1.7 1 0 0 1 1 1 0 Osmosensory transporter coiled coil GPS2_interact PF15784.5 EFE38522.1 - 0.041 14.3 0.4 0.041 14.3 0.4 2.2 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain LPP PF04728.13 EFE38522.1 - 0.1 13.0 2.3 0.11 13.0 0.1 2.1 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DUF3338 PF11819.8 EFE38522.1 - 0.11 12.5 7.5 1.7 8.6 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3338) Mei5 PF10376.9 EFE38522.1 - 0.18 11.7 7.8 0.23 11.3 7.8 1.1 1 0 0 1 1 1 0 Double-strand recombination repair protein RGCC PF15151.6 EFE38522.1 - 0.26 11.5 4.3 0.12 12.7 1.7 1.7 2 0 0 2 2 2 0 Response gene to complement 32 protein family Syntaxin-6_N PF09177.11 EFE38522.1 - 0.27 11.8 5.6 3.3 8.3 5.5 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal CENP-F_leu_zip PF10473.9 EFE38522.1 - 0.29 11.2 14.6 0.3 11.1 0.4 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 EFE38522.1 - 0.5 10.4 3.0 1.9 8.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 EFE38522.1 - 0.61 10.3 11.0 0.71 10.1 0.6 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain GAS PF13851.6 EFE38522.1 - 0.65 9.3 11.6 4.7 6.5 6.3 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EFE38522.1 - 1.4 9.4 19.2 0.87 10.1 1.8 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region bZIP_1 PF00170.21 EFE38522.1 - 1.6 8.9 12.4 0.11 12.6 2.4 2.2 2 0 0 2 2 2 0 bZIP transcription factor Spc7 PF08317.11 EFE38522.1 - 1.8 7.4 12.1 0.92 8.3 0.3 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein CENP-H PF05837.12 EFE38522.1 - 2.3 8.7 10.9 1.4 9.4 0.6 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DivIC PF04977.15 EFE38522.1 - 6.1 6.7 12.1 2.8 7.8 0.6 2.3 2 0 0 2 2 2 0 Septum formation initiator Fungal_trans PF04082.18 EFE38523.1 - 5.7e-20 71.5 0.4 9.2e-20 70.8 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain N2227 PF07942.12 EFE38524.1 - 5.2e-87 291.5 0.0 9.2e-87 290.7 0.0 1.4 1 1 0 1 1 1 1 N2227-like protein SelP_N PF04592.14 EFE38524.1 - 1.1 8.6 6.9 2.7 7.3 6.9 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ATG22 PF11700.8 EFE38526.1 - 3.6e-118 395.2 26.4 9.4e-118 393.8 26.4 1.6 1 1 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EFE38526.1 - 1.4e-09 37.3 32.2 2.4e-05 23.4 20.9 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily Ras PF00071.22 EFE38527.1 - 2.4e-53 180.0 0.3 3.1e-53 179.7 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE38527.1 - 5e-31 107.4 0.2 9.2e-31 106.6 0.1 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE38527.1 - 5.2e-12 45.6 0.1 6.3e-12 45.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFE38527.1 - 3.4e-07 30.0 0.0 4.1e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFE38527.1 - 0.00068 19.1 0.0 0.00085 18.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFE38527.1 - 0.058 13.3 0.3 0.18 11.7 0.2 1.8 1 1 2 3 3 3 0 RsgA GTPase AAT PF03417.16 EFE38527.1 - 0.13 11.9 0.2 0.2 11.3 0.2 1.2 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Mitofilin PF09731.9 EFE38528.1 - 1.8e-149 499.5 27.1 1.8e-121 407.0 32.0 2.1 1 1 1 2 2 2 2 Mitochondrial inner membrane protein ATP-synt_B PF00430.18 EFE38528.1 - 0.031 14.3 17.9 0.24 11.5 7.7 2.6 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Ribosomal_L20 PF00453.18 EFE38528.1 - 0.052 13.6 2.1 0.12 12.5 2.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L20 ArnB_C PF18677.1 EFE38528.1 - 0.095 12.8 9.4 11 6.2 0.0 4.0 4 0 0 4 4 4 0 Archaellum regulatory network B, C-terminal domain DUF2205 PF10224.9 EFE38528.1 - 0.47 10.5 6.4 0.18 11.8 2.0 2.5 1 1 0 2 2 2 0 Short coiled-coil protein YqhG PF11079.8 EFE38528.1 - 0.59 9.0 3.1 1 8.3 3.1 1.3 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function DUF4363 PF14276.6 EFE38528.1 - 0.62 10.2 5.7 1.6 8.9 0.0 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4363) Leucyl-specific PF14795.6 EFE38530.1 - 0.055 13.5 0.2 0.089 12.9 0.2 1.3 1 0 0 1 1 1 0 Leucine-tRNA synthetase-specific domain DSBA PF01323.20 EFE38532.1 - 1e-11 45.0 0.0 3.1e-11 43.4 0.0 1.7 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Bromodomain PF00439.25 EFE38533.1 - 4.3e-23 81.2 0.3 9.1e-23 80.1 0.3 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EFE38533.1 - 6.6e-08 32.8 0.1 1.2e-07 32.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE38533.1 - 4.4e-07 29.9 0.1 7.5e-07 29.1 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE38533.1 - 5.7e-05 23.5 0.2 0.00011 22.6 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE38533.1 - 0.032 14.2 0.0 0.054 13.5 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Methyltransf_16 PF10294.9 EFE38535.1 - 4.5e-44 150.2 0.0 1.3e-41 142.2 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 EFE38535.1 - 0.00027 20.8 0.0 0.00056 19.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38535.1 - 0.00033 21.3 0.0 0.00075 20.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38535.1 - 0.00095 19.9 0.2 0.012 16.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38535.1 - 0.0044 16.8 0.0 0.0075 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFE38535.1 - 0.0072 15.9 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain VWA_CoxE PF05762.14 EFE38535.1 - 0.06 12.7 0.1 0.06 12.7 0.1 1.7 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein PrmA PF06325.13 EFE38535.1 - 0.19 11.1 0.1 0.29 10.5 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Orn_Arg_deC_N PF02784.16 EFE38536.1 - 6.9e-83 277.8 0.0 1.1e-82 277.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFE38536.1 - 3.8e-18 65.5 0.0 4.7e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 EFE38536.1 - 0.0081 15.6 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Luteo_P1-P2 PF08467.10 EFE38536.1 - 0.011 15.0 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 Luteovirus RNA polymerase P1-P2/replicase cobW PF02492.19 EFE38537.1 - 2.8e-42 144.3 0.0 4.1e-42 143.8 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EFE38537.1 - 0.00083 19.3 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B CobW_C PF07683.14 EFE38537.1 - 0.0015 18.4 0.0 0.0075 16.2 0.0 2.1 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.6 EFE38537.1 - 0.033 14.5 0.0 0.069 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EFE38537.1 - 0.056 13.2 0.0 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Pox_A32 PF04665.12 EFE38537.1 - 0.12 11.8 0.1 0.28 10.6 0.0 1.6 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_29 PF13555.6 EFE38537.1 - 0.13 12.0 0.2 1.2 8.9 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_14 PF13173.6 EFE38537.1 - 0.21 11.6 0.0 0.45 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain SET PF00856.28 EFE38538.1 - 1.6e-07 31.8 0.0 2.6e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 SET domain Glyco_transf_54 PF04666.13 EFE38539.1 - 4.8e-14 51.9 0.0 6.7e-10 38.3 0.0 3.1 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF2754 PF10953.8 EFE38539.1 - 0.0041 17.3 0.2 0.009 16.2 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2754) Cation_efflux PF01545.21 EFE38539.1 - 0.12 12.1 0.3 0.59 9.8 0.1 2.0 2 0 0 2 2 2 0 Cation efflux family DNA_mis_repair PF01119.19 EFE38540.1 - 4.1e-11 42.6 0.0 9.5e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EFE38541.1 - 3.4e-09 36.7 0.1 5.4e-09 36.0 0.1 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFE38541.1 - 2.9e-07 31.0 0.0 4.8e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Rtt106_N PF18215.1 EFE38541.1 - 0.012 15.4 0.0 0.025 14.3 0.0 1.6 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain APH PF01636.23 EFE38542.1 - 6.9e-14 52.4 0.1 1.8e-13 51.0 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EFE38542.1 - 0.0015 17.8 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Fructosamine kinase Fungal_trans PF04082.18 EFE38543.1 - 0.0028 16.7 1.1 0.0077 15.3 0.4 1.8 1 1 1 2 2 2 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EFE38544.1 - 4e-41 141.1 44.3 7.5e-41 140.2 41.6 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE38544.1 - 1.9e-07 29.9 16.8 2.5e-07 29.5 16.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Acetyltransf_3 PF13302.7 EFE38546.1 - 3.9e-28 98.9 0.1 7.4e-28 98.0 0.0 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE38546.1 - 4e-05 23.8 0.0 5.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 EFE38546.1 - 0.0015 18.2 0.0 0.0036 17.0 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain PBAN PF05874.11 EFE38546.1 - 0.026 14.4 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Pheromone biosynthesis activating neuropeptide (PBAN) Pkinase PF00069.25 EFE38547.1 - 4.7e-57 193.3 0.4 1.3e-51 175.6 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38547.1 - 5.5e-33 114.3 0.2 1e-31 110.2 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase POLO_box PF00659.18 EFE38547.1 - 9e-06 25.8 0.0 0.061 13.5 0.0 3.0 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EFE38547.1 - 2.1e-05 24.0 0.0 3.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFE38547.1 - 0.0041 16.5 0.1 0.0063 15.9 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFE38547.1 - 0.0049 15.9 0.0 0.0093 14.9 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Tau95 PF09734.9 EFE38547.1 - 0.16 12.8 1.0 0.47 11.2 1.0 1.8 1 0 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Pkinase_fungal PF17667.1 EFE38547.1 - 0.31 9.8 0.0 0.31 9.8 0.0 1.9 2 1 0 2 2 2 0 Fungal protein kinase OPA3 PF07047.12 EFE38548.1 - 8.5e-23 80.5 0.3 1.2e-22 80.0 0.3 1.2 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DUF4472 PF14739.6 EFE38548.1 - 0.49 11.1 7.9 0.22 12.3 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) APG6_N PF17675.1 EFE38548.1 - 7.6 7.1 13.9 0.24 11.9 4.0 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region Myosin_head PF00063.21 EFE38549.1 - 3.5e-241 802.2 4.7 4.1e-241 801.9 4.7 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFE38549.1 - 5.5e-31 107.7 0.0 5.8e-21 75.0 0.0 2.4 1 1 1 2 2 2 2 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EFE38549.1 - 0.0012 18.4 0.0 0.0028 17.2 0.0 1.7 1 0 0 1 1 1 1 SH3 domain IQ PF00612.27 EFE38549.1 - 0.0096 15.6 8.7 0.49 10.3 0.6 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif AAA_22 PF13401.6 EFE38549.1 - 0.011 16.0 0.0 0.04 14.2 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.6 EFE38549.1 - 0.016 15.6 0.0 0.046 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Hpr_kinase_C PF07475.12 EFE38549.1 - 0.023 14.2 0.5 3.4 7.2 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain SH3_2 PF07653.17 EFE38549.1 - 0.027 14.1 0.0 0.087 12.5 0.0 1.9 2 0 0 2 2 2 0 Variant SH3 domain SH3_9 PF14604.6 EFE38549.1 - 0.14 12.0 0.0 0.5 10.3 0.0 2.0 1 0 0 1 1 1 0 Variant SH3 domain TrwB_AAD_bind PF10412.9 EFE38549.1 - 0.15 11.0 0.1 0.31 9.9 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_33 PF13671.6 EFE38549.1 - 0.16 12.1 0.2 5.4 7.2 0.0 3.2 4 0 0 4 4 4 0 AAA domain NACHT PF05729.12 EFE38549.1 - 0.2 11.6 0.0 0.48 10.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain GRA6 PF05084.13 EFE38550.1 - 0.00057 19.9 0.1 0.0018 18.3 0.1 1.8 1 0 0 1 1 1 1 Granule antigen protein (GRA6) DUF4229 PF14012.6 EFE38550.1 - 0.0077 16.3 0.4 0.018 15.1 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4229) CBP_BcsF PF11120.8 EFE38550.1 - 0.043 13.9 0.6 0.1 12.8 0.6 1.6 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF RSN1_TM PF13967.6 EFE38550.1 - 0.069 12.9 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport Sulf_transp PF04143.14 EFE38550.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Sulphur transport DUF1180 PF06679.12 EFE38550.1 - 0.15 12.5 0.1 0.15 12.5 0.1 3.4 4 1 0 4 4 4 0 Protein of unknown function (DUF1180) DUF2207 PF09972.9 EFE38550.1 - 0.34 9.6 1.0 0.53 9.0 0.0 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) p450 PF00067.22 EFE38551.1 - 2.7e-51 174.7 0.0 1.4e-33 116.3 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Gelsolin PF00626.22 EFE38552.1 - 0.1 12.5 0.3 0.22 11.5 0.3 1.7 1 1 0 1 1 1 0 Gelsolin repeat DUF2514 PF10721.9 EFE38553.1 - 0.49 10.4 13.2 0.7 9.9 13.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) TrkH PF02386.16 EFE38554.1 - 1.8e-144 481.9 2.8 1.8e-142 475.3 1.9 2.1 2 0 0 2 2 2 2 Cation transport protein COesterase PF00135.28 EFE38555.1 - 1.4e-33 116.6 0.0 3.1e-27 95.6 0.0 2.9 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE38555.1 - 1.2e-08 35.1 0.0 2.3e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold ATP-synt_ab PF00006.25 EFE38556.1 - 3.3e-109 363.5 0.0 7.9e-109 362.3 0.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_M PF01031.20 EFE38556.1 - 1.7e-100 336.0 0.4 1.2e-99 333.2 0.0 2.4 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 EFE38556.1 - 1.6e-56 191.0 0.2 3.6e-56 189.8 0.2 1.7 1 0 0 1 1 1 1 Dynamin family ATP-synt_ab_Xtn PF16886.5 EFE38556.1 - 7.3e-44 148.5 0.0 1.5e-43 147.5 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension GED PF02212.18 EFE38556.1 - 2.3e-29 101.4 2.8 6.5e-29 99.9 2.8 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EFE38556.1 - 2.1e-05 24.6 0.7 0.00011 22.3 0.7 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFE38556.1 - 0.0047 17.3 0.1 0.58 10.5 0.0 3.4 3 1 0 3 3 3 1 AAA ATPase domain AAA_28 PF13521.6 EFE38556.1 - 0.097 12.9 0.1 9.6 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 EFE38557.1 - 7.8e-24 83.5 7.2 0.0021 18.9 0.0 8.0 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE38557.1 - 3.4e-14 52.9 0.9 0.0017 18.6 0.0 5.5 2 1 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE38557.1 - 2.8e-05 23.2 0.0 0.021 13.8 0.0 3.3 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EFE38557.1 - 0.00031 20.6 0.2 14 5.8 0.0 4.6 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat eIF2A PF08662.11 EFE38557.1 - 0.001 19.0 0.0 0.24 11.3 0.0 2.5 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EFE38557.1 - 0.14 10.6 0.0 0.75 8.3 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain DEAD PF00270.29 EFE38558.1 - 1.4e-41 142.2 0.1 2.4e-41 141.4 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE38558.1 - 1.6e-33 115.3 0.1 6.7e-33 113.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EFE38558.1 - 0.00069 19.4 0.0 0.001 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EFE38558.1 - 0.00083 19.4 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFE38558.1 - 0.0028 18.0 0.1 0.028 14.8 0.1 2.2 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 EFE38558.1 - 0.038 14.0 0.3 0.15 12.1 0.1 2.2 1 1 1 2 2 2 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 EFE38558.1 - 0.05 13.4 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Helicase TniB PF05621.11 EFE38558.1 - 0.06 12.7 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein DUF5393 PF17371.2 EFE38558.1 - 0.11 10.6 0.1 0.17 9.9 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5393) AAA_22 PF13401.6 EFE38558.1 - 0.24 11.7 1.1 1.3 9.3 1.1 2.1 1 1 0 1 1 1 0 AAA domain DUF3449 PF11931.8 EFE38559.1 - 2.1e-76 255.9 0.3 2.1e-76 255.9 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EFE38559.1 - 4.4e-23 81.6 1.8 6.7e-23 81.0 0.6 1.9 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EFE38559.1 - 2.2e-11 43.4 0.2 4.5e-11 42.4 0.2 1.6 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 EFE38559.1 - 2.5e-09 37.2 3.9 1.1e-07 32.0 1.0 2.4 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFE38559.1 - 7e-08 32.6 1.0 7e-08 32.6 1.0 2.7 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EFE38559.1 - 0.00027 21.2 0.9 0.01 16.2 0.3 2.8 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.11 EFE38559.1 - 0.049 13.6 0.2 0.13 12.2 0.2 1.7 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-C2H2_4 PF13894.6 EFE38559.1 - 0.082 13.8 1.4 5 8.2 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE38559.1 - 2.6 8.7 4.3 5.3 7.7 0.5 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type AbiEi_1 PF09407.10 EFE38560.1 - 0.067 13.5 0.0 0.084 13.2 0.0 1.1 1 0 0 1 1 1 0 AbiEi antitoxin C-terminal domain DNA_ligase_A_M PF01068.21 EFE38561.1 - 2.2e-22 79.7 0.0 3.7e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFE38561.1 - 6.3e-20 72.2 0.0 1.3e-19 71.2 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DUF2408 PF10303.9 EFE38561.1 - 0.13 12.8 0.6 1.6 9.3 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) ANAPC8 PF04049.13 EFE38562.1 - 6.6e-53 178.5 0.0 2.4e-52 176.7 0.0 2.0 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 EFE38562.1 - 1.8e-25 87.6 7.0 0.00018 21.2 0.0 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFE38562.1 - 1.4e-21 74.8 17.1 1.8e-05 24.6 0.0 9.3 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFE38562.1 - 3.3e-21 73.6 23.8 0.061 13.5 2.8 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_19 PF14559.6 EFE38562.1 - 8.6e-14 51.8 7.3 0.065 13.8 0.4 7.6 6 2 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFE38562.1 - 1.5e-12 47.2 20.0 0.007 17.1 0.0 8.9 7 2 2 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 EFE38562.1 - 3.8e-11 43.5 20.2 1.7e-05 25.4 0.0 7.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFE38562.1 - 4.7e-11 42.2 4.0 1.1e-06 28.2 0.3 4.9 3 2 2 5 5 5 2 TPR repeat TPR_12 PF13424.6 EFE38562.1 - 4.9e-11 42.8 7.5 0.24 11.7 0.0 7.0 6 1 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE38562.1 - 3.4e-10 40.0 18.3 0.11 12.8 0.3 6.9 8 0 0 8 8 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFE38562.1 - 6.1e-10 39.1 13.4 0.00012 22.1 0.4 6.1 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFE38562.1 - 4.8e-08 32.8 2.8 1.3 9.5 0.0 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFE38562.1 - 1.5e-06 28.5 24.4 0.72 10.6 0.2 9.3 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFE38562.1 - 0.00074 19.4 11.8 1.9 8.7 0.1 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFE38562.1 - 0.0039 16.5 4.5 0.0039 16.5 4.5 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFE38562.1 - 0.05 13.2 0.0 0.16 11.6 0.0 1.8 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_10 PF13374.6 EFE38562.1 - 0.093 12.6 7.7 22 5.1 0.1 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_3 PF07720.12 EFE38562.1 - 0.26 11.3 3.5 0.5 10.4 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.12 EFE38562.1 - 0.33 11.7 8.8 14 6.6 0.1 4.3 4 0 0 4 4 3 0 Sel1 repeat PPR PF01535.20 EFE38562.1 - 0.86 10.0 4.2 38 4.8 0.0 4.5 5 0 0 5 5 5 0 PPR repeat polyprenyl_synt PF00348.17 EFE38563.1 - 1.6e-90 302.6 0.0 2e-90 302.3 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Glycogen_syn PF05693.13 EFE38564.1 - 0 1045.5 0.0 0 1045.3 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.6 EFE38564.1 - 9.9e-06 25.7 0.2 2.1e-05 24.6 0.2 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EFE38564.1 - 1.8e-05 24.4 0.0 0.0056 16.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFE38564.1 - 2.2e-05 24.9 0.0 0.027 14.9 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFE38564.1 - 2.3e-05 24.9 0.0 5.8e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 EFE38564.1 - 0.00037 20.3 0.1 0.00079 19.2 0.1 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain NPCC PF08058.11 EFE38566.1 - 1.7e-15 57.2 0.0 2e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore complex component DUF3719 PF12516.8 EFE38566.1 - 0.13 12.0 0.1 17 5.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3719) AMP-binding PF00501.28 EFE38567.1 - 1.6e-16 60.0 0.0 4e-07 29.0 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme DUF3688 PF12461.8 EFE38568.1 - 0.24 9.8 0.1 0.33 9.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3688) Ribosomal_L19 PF01245.20 EFE38569.1 - 5.1e-11 42.5 0.1 1.2e-10 41.3 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L19 Methyltransf_24 PF13578.6 EFE38570.1 - 1.6e-10 41.9 0.0 5.3e-10 40.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 EFE38570.1 - 0.011 14.9 0.3 0.084 12.0 0.2 2.2 2 1 0 2 2 2 0 O-methyltransferase bZIP_1 PF00170.21 EFE38571.1 - 7.9e-08 32.3 11.9 2.1e-07 30.9 11.9 1.7 1 0 0 1 1 1 1 bZIP transcription factor Hap4_Hap_bind PF10297.9 EFE38571.1 - 9.6e-08 31.9 6.9 2.3e-07 30.7 6.9 1.7 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 DUF812 PF05667.11 EFE38571.1 - 0.0082 15.1 6.4 0.012 14.5 6.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) dsrm PF00035.26 EFE38571.1 - 0.068 13.9 0.0 0.19 12.4 0.0 1.8 1 0 0 1 1 1 0 Double-stranded RNA binding motif PSI_PsaF PF02507.15 EFE38571.1 - 0.18 11.7 1.2 0.31 10.9 1.2 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III SlyX PF04102.12 EFE38571.1 - 0.5 11.0 7.9 1.5 9.5 6.6 2.3 1 1 1 2 2 2 0 SlyX bZIP_2 PF07716.15 EFE38571.1 - 0.88 9.7 19.7 3.6 7.7 18.9 2.3 1 1 1 2 2 2 0 Basic region leucine zipper Golgin_A5 PF09787.9 EFE38571.1 - 1.3 8.4 12.8 2.9 7.3 12.7 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 DUF737 PF05300.11 EFE38571.1 - 1.8 8.8 15.6 0.18 12.2 9.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF737) V_ATPase_I PF01496.19 EFE38571.1 - 8.8 4.1 6.6 11 3.8 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mito_carr PF00153.27 EFE38572.1 - 1.6e-09 37.5 2.7 0.015 15.2 0.1 4.9 4 1 0 4 4 4 4 Mitochondrial carrier protein Fer2 PF00111.27 EFE38573.1 - 0.039 13.9 0.1 1.7 8.6 0.1 2.3 1 1 1 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Rrp15p PF07890.12 EFE38574.1 - 1.2e-38 132.5 8.3 1.2e-38 132.5 8.3 2.0 3 0 0 3 3 3 1 Rrp15p RRN3 PF05327.11 EFE38574.1 - 0.072 11.6 5.3 0.1 11.2 5.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF1299 PF06975.11 EFE38574.1 - 0.13 12.3 0.7 0.13 12.3 0.7 3.1 2 2 0 2 2 2 0 Protein of unknown function (DUF1299) FliL PF03748.14 EFE38574.1 - 3.1 8.4 6.2 20 5.8 0.0 3.1 2 1 1 3 3 3 0 Flagellar basal body-associated protein FliL SRP54 PF00448.22 EFE38575.1 - 4e-73 245.3 1.9 7.3e-73 244.4 1.9 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EFE38575.1 - 2e-28 98.9 0.1 2e-28 98.9 0.1 4.3 2 2 3 5 5 4 1 Signal peptide binding domain SRP54_N PF02881.19 EFE38575.1 - 1.5e-11 44.4 0.2 3.8e-11 43.0 0.2 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EFE38575.1 - 9.9e-07 28.5 0.9 4.2e-06 26.5 0.8 2.1 2 1 0 2 2 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EFE38575.1 - 1.2e-06 28.8 0.1 2.8e-06 27.5 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFE38575.1 - 3e-05 24.5 0.1 3e-05 24.5 0.1 1.9 2 0 0 2 2 1 1 AAA domain Zeta_toxin PF06414.12 EFE38575.1 - 9.7e-05 21.7 0.1 0.00018 20.9 0.1 1.4 1 0 0 1 1 1 1 Zeta toxin MeaB PF03308.16 EFE38575.1 - 0.00051 19.1 2.0 0.0034 16.4 0.0 2.7 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EFE38575.1 - 0.00067 20.1 0.0 0.0015 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain ResIII PF04851.15 EFE38575.1 - 0.00082 19.4 1.0 0.0041 17.1 1.2 2.1 2 1 0 2 2 1 1 Type III restriction enzyme, res subunit APS_kinase PF01583.20 EFE38575.1 - 0.00087 19.2 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP_bind_1 PF03029.17 EFE38575.1 - 0.002 18.0 0.6 0.022 14.5 0.1 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein 6PF2K PF01591.18 EFE38575.1 - 0.0027 17.0 0.0 0.0049 16.2 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_30 PF13604.6 EFE38575.1 - 0.0036 17.0 0.4 0.0036 17.0 0.4 2.1 2 1 0 2 2 2 1 AAA domain SRPRB PF09439.10 EFE38575.1 - 0.0058 16.1 2.1 2 7.8 1.7 2.9 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit CbiA PF01656.23 EFE38575.1 - 0.0061 16.6 0.0 0.01 15.9 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Thymidylate_kin PF02223.17 EFE38575.1 - 0.0096 15.6 0.2 0.035 13.8 0.2 1.9 1 0 0 1 1 1 1 Thymidylate kinase AAA_22 PF13401.6 EFE38575.1 - 0.012 15.9 0.3 0.047 14.0 0.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFE38575.1 - 0.015 15.9 0.1 0.038 14.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain Methyltransf_25 PF13649.6 EFE38575.1 - 0.015 16.0 0.1 1.1 10.1 0.0 2.8 2 0 0 2 2 2 0 Methyltransferase domain MMR_HSR1 PF01926.23 EFE38575.1 - 0.017 15.2 0.2 0.068 13.2 0.2 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase Arf PF00025.21 EFE38575.1 - 0.036 13.5 0.0 0.09 12.2 0.0 1.7 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_24 PF13479.6 EFE38575.1 - 0.044 13.5 0.1 0.1 12.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 EFE38575.1 - 0.051 13.5 0.1 0.14 12.0 0.1 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.6 EFE38575.1 - 0.058 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain VirE PF05272.11 EFE38575.1 - 0.091 12.5 0.1 0.22 11.2 0.1 1.6 1 0 0 1 1 1 0 Virulence-associated protein E AAA_31 PF13614.6 EFE38575.1 - 0.093 12.6 1.0 0.67 9.9 0.2 2.2 1 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFE38575.1 - 0.1 13.1 0.9 0.31 11.6 0.1 2.1 2 1 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 EFE38575.1 - 0.2 11.5 0.9 0.73 9.7 0.9 2.1 1 1 0 1 1 1 0 NTPase PhoD PF09423.10 EFE38576.1 - 1.7e-38 132.5 0.0 6.4e-38 130.7 0.0 1.8 1 1 0 1 1 1 1 PhoD-like phosphatase Glyco_hydro_18 PF00704.28 EFE38577.1 - 3.9e-15 56.4 0.0 4.6e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF496 PF04363.12 EFE38577.1 - 0.16 12.0 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF496) Peptidase_S3 PF00944.19 EFE38578.1 - 0.044 13.6 0.1 0.098 12.5 0.1 1.5 1 0 0 1 1 1 0 Alphavirus core protein VAR1 PF05316.12 EFE38578.1 - 0.044 12.8 0.2 0.064 12.3 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein (VAR1) adh_short_C2 PF13561.6 EFE38579.1 - 3.7e-52 177.2 2.0 1.1e-51 175.7 0.1 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE38579.1 - 2.2e-42 144.7 1.5 9.7e-38 129.6 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EFE38579.1 - 6.1e-11 42.5 2.6 1.6e-10 41.2 2.6 1.6 1 1 0 1 1 1 1 KR domain CcmE PF03100.15 EFE38579.1 - 0.057 13.4 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 CcmE Macoilin PF09726.9 EFE38580.1 - 0.00016 20.4 62.5 0.0036 16.0 31.3 2.4 2 0 0 2 2 2 2 Macoilin family CoA_transf_3 PF02515.17 EFE38581.1 - 3.2e-61 207.5 0.0 3.9e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III zinc_ribbon_16 PF17034.5 EFE38582.1 - 3.9e-25 88.5 10.9 9.4e-25 87.2 10.9 1.7 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EFE38582.1 - 1.5e-05 24.5 6.8 1.5e-05 24.5 6.8 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 EFE38582.1 - 0.53 10.6 10.0 0.054 13.8 4.7 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFE38582.1 - 1.8 8.5 8.2 0.12 12.2 0.9 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Efg1 PF10153.9 EFE38583.1 - 4.1e-26 91.6 14.2 4.1e-26 91.6 14.2 2.8 3 1 0 3 3 3 1 rRNA-processing protein Efg1 DUF573 PF04504.14 EFE38583.1 - 0.02 15.5 2.7 0.02 15.5 2.7 3.2 2 1 2 4 4 4 0 Protein of unknown function, DUF573 MCM3AP_GANP PF16769.5 EFE38583.1 - 1.8 6.7 9.7 2.6 6.2 9.7 1.1 1 0 0 1 1 1 0 MCM3AP domain of GANP LRR_6 PF13516.6 EFE38584.1 - 5.9e-13 47.7 13.0 0.0032 17.4 0.1 7.1 7 0 0 7 7 7 5 Leucine Rich repeat F-box-like PF12937.7 EFE38584.1 - 5.8e-11 42.1 0.2 1.8e-10 40.6 0.2 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE38584.1 - 5.9e-10 38.8 0.3 1.7e-09 37.3 0.3 1.8 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 EFE38584.1 - 2.1e-05 24.8 20.8 0.00014 22.2 1.2 5.1 5 2 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFE38584.1 - 0.00062 20.0 17.5 0.46 11.2 0.4 7.1 8 0 0 8 8 8 2 Leucine Rich Repeat PRANC PF09372.10 EFE38584.1 - 0.017 15.5 0.0 0.045 14.1 0.0 1.7 1 0 0 1 1 1 0 PRANC domain LRR_8 PF13855.6 EFE38584.1 - 0.12 12.1 4.7 13 5.6 0.1 4.2 4 1 0 4 4 4 0 Leucine rich repeat Pkinase PF00069.25 EFE38585.1 - 1.3e-54 185.4 0.0 1.9e-54 184.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38585.1 - 1e-19 70.9 0.0 1.7e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE38585.1 - 8.2e-05 22.1 0.0 0.00017 21.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFE38585.1 - 9.3e-05 21.5 0.0 0.00016 20.7 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFE38585.1 - 0.00052 20.0 0.1 0.002 18.1 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE38585.1 - 0.0072 15.2 0.0 0.014 14.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EFE38585.1 - 0.0074 15.9 0.3 0.017 14.7 0.3 1.6 1 1 0 1 1 1 1 RIO1 family PAS_9 PF13426.7 EFE38585.1 - 0.021 15.1 0.0 8.6 6.7 0.0 2.9 2 0 0 2 2 2 0 PAS domain Choline_kinase PF01633.20 EFE38585.1 - 0.081 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RabGAP-TBC PF00566.18 EFE38586.1 - 9.8e-33 113.6 0.1 1.7e-32 112.8 0.1 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF5102 PF17104.5 EFE38587.1 - 0.36 10.8 3.8 1.2 9.1 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5102) Yippee-Mis18 PF03226.14 EFE38588.1 - 2.6e-18 66.1 0.4 3e-18 66.0 0.4 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EFE38588.1 - 0.0015 18.7 2.4 0.0021 18.3 2.4 1.3 1 0 0 1 1 1 1 C-terminal domain of RIG-I DUF2039 PF10217.9 EFE38588.1 - 0.0083 16.4 1.8 0.064 13.6 0.2 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2039) DUF4451 PF14616.6 EFE38588.1 - 0.0084 16.3 2.5 0.013 15.7 2.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4451) HNH_5 PF14279.6 EFE38588.1 - 0.031 14.1 1.1 0.18 11.7 0.1 2.1 2 0 0 2 2 2 0 HNH endonuclease Endonuclease_7 PF02945.15 EFE38588.1 - 0.038 13.9 2.3 0.077 12.9 2.3 1.7 1 1 0 1 1 1 0 Recombination endonuclease VII Eapp_C PF10238.9 EFE38588.1 - 0.16 12.0 3.5 0.9 9.6 3.5 2.0 1 1 0 1 1 1 0 E2F-associated phosphoprotein Evr1_Alr PF04777.13 EFE38588.1 - 0.35 11.4 2.7 1.8 9.0 0.4 2.1 1 1 1 2 2 2 0 Erv1 / Alr family ADH_zinc_N PF00107.26 EFE38589.1 - 9.9e-18 64.4 0.0 1.3e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFE38589.1 - 1.1e-06 28.3 0.0 1.5e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EFE38589.1 - 0.003 18.6 0.0 0.0042 18.1 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFE38589.1 - 0.019 14.3 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Dehydratase_hem PF13816.6 EFE38590.1 - 1.6e-114 382.4 0.0 1.9e-114 382.2 0.0 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF4188 PF13826.6 EFE38590.1 - 1.7e-08 34.8 0.1 0.0008 19.7 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4188) NAD_binding_2 PF03446.15 EFE38591.1 - 1.3e-25 90.4 0.2 3e-25 89.2 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFE38591.1 - 1.3e-11 44.8 1.0 2.1e-11 44.1 1.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EFE38591.1 - 7e-07 29.4 0.1 2e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EFE38591.1 - 2.7e-06 27.9 0.3 1.1e-05 25.9 0.1 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ADH_zinc_N PF00107.26 EFE38591.1 - 0.028 14.4 1.2 4.9 7.1 0.0 2.8 2 0 0 2 2 2 0 Zinc-binding dehydrogenase F-box-like PF12937.7 EFE38592.1 - 0.00029 20.7 0.9 0.00079 19.3 0.9 1.8 1 0 0 1 1 1 1 F-box-like Abhydrolase_6 PF12697.7 EFE38593.1 - 2.9e-15 57.5 0.3 3.6e-15 57.2 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFE38593.1 - 7.6e-12 45.4 0.3 3.6e-10 39.9 0.1 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE38593.1 - 1e-11 44.6 0.1 1.4e-11 44.1 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EFE38593.1 - 0.00029 21.0 0.0 0.00048 20.3 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EFE38593.1 - 0.002 17.9 0.0 0.0032 17.2 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Peptidase_S28 PF05577.12 EFE38593.1 - 0.015 14.1 0.0 0.022 13.6 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 YjbR PF04237.13 EFE38595.1 - 0.11 13.1 0.1 3.9 8.1 0.0 2.3 1 1 1 2 2 2 0 YjbR Thioredoxin PF00085.20 EFE38596.1 - 7.9e-56 186.4 0.0 1.7e-27 95.4 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 EFE38596.1 - 2.4e-24 86.0 0.6 9.4e-24 84.1 0.3 2.0 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 EFE38596.1 - 3.4e-14 53.2 0.0 6.8e-06 26.5 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EFE38596.1 - 1.6e-12 47.4 0.0 1.2e-05 24.9 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EFE38596.1 - 2.6e-08 33.9 0.0 0.00023 21.3 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 EFE38596.1 - 5e-07 29.7 0.0 0.017 15.0 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_8 PF13905.6 EFE38596.1 - 5e-06 26.8 0.0 0.41 11.0 0.0 3.6 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_9 PF14595.6 EFE38596.1 - 0.00096 18.9 0.1 0.51 10.1 0.0 3.2 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_6 PF13848.6 EFE38596.1 - 0.0073 16.2 0.0 2.2 8.2 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin-like domain Glutaredoxin PF00462.24 EFE38596.1 - 0.0075 16.5 0.1 9.3 6.6 0.1 3.0 2 1 0 2 2 2 2 Glutaredoxin TraF PF13728.6 EFE38596.1 - 0.0078 16.1 0.0 1.3 8.8 0.0 2.3 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_4 PF13462.6 EFE38596.1 - 0.042 14.0 3.0 6.8 6.8 0.1 3.9 3 2 0 3 3 3 0 Thioredoxin HyaE PF07449.11 EFE38596.1 - 0.14 12.1 0.0 8.7 6.4 0.0 2.5 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Ebp2 PF05890.12 EFE38597.1 - 4.1e-94 315.1 15.2 4.1e-94 315.1 15.2 2.4 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 BUD22 PF09073.10 EFE38597.1 - 6.2 6.0 58.9 0.15 11.4 38.0 2.1 2 0 0 2 2 2 0 BUD22 CNDH2_C PF16858.5 EFE38597.1 - 8.4 6.2 35.3 0.16 11.8 20.3 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Nop14 PF04147.12 EFE38597.1 - 9.7 4.3 57.8 0.021 13.1 39.0 2.1 2 0 0 2 2 2 0 Nop14-like family Neuregulin PF02158.15 EFE38598.1 - 0.00053 19.5 3.4 0.00082 18.8 3.4 1.2 1 0 0 1 1 1 1 Neuregulin intracellular region DNMT1-RFD PF12047.8 EFE38598.1 - 0.014 15.4 0.0 0.074 13.1 0.0 2.2 2 0 0 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain E3_UbLigase_EDD PF11547.8 EFE38598.1 - 0.016 14.9 1.2 0.046 13.4 1.2 1.7 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD RNase_T PF00929.24 EFE38598.1 - 0.046 14.3 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 Exonuclease PIEZO PF15917.5 EFE38598.1 - 0.23 10.9 1.1 0.44 10.0 1.1 1.4 1 0 0 1 1 1 0 Piezo Drc1-Sld2 PF11719.8 EFE38598.1 - 0.96 8.9 11.6 0.67 9.4 10.1 1.4 1 1 0 1 1 1 0 DNA replication and checkpoint protein TruB_N PF01509.18 EFE38599.1 - 3.9e-44 150.6 0.0 1.7e-43 148.6 0.0 1.9 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EFE38599.1 - 1.1e-06 28.7 0.0 2.9e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain DUF3043 PF11241.8 EFE38601.1 - 5.3 7.0 7.8 7.7 6.5 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) OHCU_decarbox PF09349.10 EFE38602.1 - 1e-39 136.5 0.0 1.4e-39 136.0 0.0 1.2 1 0 0 1 1 1 1 OHCU decarboxylase DUF3684 PF12449.8 EFE38602.1 - 0.014 13.2 0.0 0.019 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3684) CorA PF01544.18 EFE38602.1 - 0.069 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein WD40 PF00400.32 EFE38603.1 - 7.4e-26 89.9 3.1 6.8e-05 23.6 0.2 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE38603.1 - 1.3e-07 31.8 0.0 1.6 9.1 0.1 5.1 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFE38603.1 - 0.00088 17.9 0.0 0.041 12.4 0.0 2.4 2 1 0 2 2 2 1 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EFE38603.1 - 0.0075 15.3 0.1 0.92 8.4 0.0 2.7 3 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFE38603.1 - 0.0097 14.6 0.3 0.23 10.1 0.3 2.6 1 1 2 3 3 3 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFE38603.1 - 0.012 14.4 0.3 11 4.7 0.0 3.7 2 2 2 4 4 4 0 Nup133 N terminal like CBM_19 PF03427.13 EFE38603.1 - 0.06 13.4 0.4 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 Carbohydrate binding domain (family 19) BBS2_Mid PF14783.6 EFE38603.1 - 0.15 12.1 0.0 12 6.0 0.0 3.7 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Nudix_N_2 PF14803.6 EFE38603.1 - 0.48 10.4 3.9 4.7 7.2 5.0 2.1 2 0 0 2 2 2 0 Nudix N-terminal SRP9-21 PF05486.12 EFE38604.1 - 1.8e-33 114.8 1.3 2.3e-33 114.4 1.3 1.1 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) TPPII_N PF12583.8 EFE38604.1 - 4.9 7.7 7.5 9 6.9 0.6 2.1 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal CBP_BcsO PF17037.5 EFE38604.1 - 5.8 7.0 8.0 1.8 8.7 2.9 2.0 1 1 1 2 2 2 0 Cellulose biosynthesis protein BcsO Glyco_transf_90 PF05686.12 EFE38605.1 - 7.7e-12 44.8 10.4 7.7e-09 34.9 7.7 3.1 2 1 0 2 2 2 2 Glycosyl transferase family 90 CDO_I PF05995.12 EFE38607.1 - 4.3e-13 48.9 0.0 3.6e-07 29.7 0.0 3.2 2 1 1 3 3 3 3 Cysteine dioxygenase type I SVIP PF15811.5 EFE38607.1 - 0.47 10.9 3.9 15 6.1 1.4 2.3 2 0 0 2 2 2 0 Small VCP/p97-interacting protein MMR_HSR1_Xtn PF16897.5 EFE38608.1 - 2.2e-39 133.7 0.3 3.5e-39 133.1 0.3 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EFE38608.1 - 1.9e-09 37.6 0.0 6.7e-09 35.8 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFE38608.1 - 0.088 12.9 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Dynamin family HTH_Tnp_Tc5 PF03221.16 EFE38611.1 - 7.6e-14 51.5 0.1 1.8e-13 50.3 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 EFE38611.1 - 0.018 14.7 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain DUF3289 PF11692.8 EFE38611.1 - 0.061 12.9 0.0 0.088 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3289) Neisseria_TspB PF05616.13 EFE38612.1 - 0.041 12.4 5.3 0.056 11.9 5.3 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein PXA PF02194.15 EFE38613.1 - 1.3e-34 119.8 0.1 3.4e-33 115.2 0.1 2.1 1 1 0 1 1 1 1 PXA domain IU_nuc_hydro PF01156.19 EFE38614.1 - 9.3e-47 160.1 0.0 1.2e-46 159.8 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MR_MLE_C PF13378.6 EFE38615.1 - 2.8e-58 197.1 0.0 3.7e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EFE38615.1 - 5.3e-18 65.3 0.0 1.2e-17 64.2 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain DUF4213 PF13938.6 EFE38615.1 - 0.089 13.0 0.0 1.9 8.8 0.0 2.7 1 1 0 1 1 1 0 Putative heavy-metal chelation OMPdecase PF00215.24 EFE38619.1 - 1.3e-65 221.2 0.1 1.4e-65 221.0 0.1 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family MAPEG PF01124.18 EFE38620.1 - 6.8e-18 64.8 1.0 8.1e-18 64.6 1.0 1.1 1 0 0 1 1 1 1 MAPEG family MBOAT PF03062.19 EFE38621.1 - 8.8e-25 87.8 15.3 1.7e-24 86.8 15.3 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EFE38621.1 - 0.01 16.1 2.4 0.029 14.6 2.4 1.8 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family Plasmodium_Vir PF05795.11 EFE38621.1 - 0.13 11.6 0.6 0.19 11.1 0.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Hydin_ADK PF17213.3 EFE38621.1 - 0.25 11.6 2.3 0.41 10.9 2.3 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF2530 PF10745.9 EFE38621.1 - 2.1 8.6 7.5 3.2 8.0 0.0 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF2530) Zip PF02535.22 EFE38621.1 - 2.7 7.1 6.6 0.92 8.7 3.9 1.6 2 0 0 2 2 2 0 ZIP Zinc transporter DUF3602 PF12223.8 EFE38621.1 - 3 8.5 5.7 5.6 7.6 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3602) HTH_32 PF13565.6 EFE38623.1 - 1.5e-07 31.9 6.7 1.6e-07 31.8 0.0 2.7 1 1 1 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 EFE38623.1 - 4e-07 30.2 0.6 8.4e-07 29.2 0.2 1.8 2 0 0 2 2 2 1 Transposase HTH_23 PF13384.6 EFE38623.1 - 4.6e-07 29.5 0.1 0.00069 19.3 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EFE38623.1 - 0.00015 21.4 0.5 0.0086 15.7 0.0 2.8 3 0 0 3 3 3 1 Sigma-70, region 4 HTH_WhiA PF02650.14 EFE38623.1 - 0.00081 19.7 0.1 0.0066 16.8 0.1 2.1 2 0 0 2 2 2 1 WhiA C-terminal HTH domain HTH_24 PF13412.6 EFE38623.1 - 0.0011 18.5 0.5 1.7 8.3 0.1 2.9 2 1 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_38 PF13936.6 EFE38623.1 - 0.0015 18.3 1.0 0.33 10.7 0.0 2.6 2 1 0 2 2 2 2 Helix-turn-helix domain HTH_20 PF12840.7 EFE38623.1 - 0.0037 17.3 0.0 2 8.6 0.0 2.3 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_29 PF13551.6 EFE38623.1 - 0.0051 16.8 8.0 0.0062 16.5 0.2 2.8 3 0 0 3 3 3 1 Winged helix-turn helix HTH_IclR PF09339.10 EFE38623.1 - 0.021 14.6 0.1 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_7 PF02796.15 EFE38623.1 - 0.04 14.0 4.1 0.27 11.3 2.0 2.9 2 1 0 2 2 2 0 Helix-turn-helix domain of resolvase Sigma70_r4 PF04545.16 EFE38623.1 - 0.042 13.4 0.0 0.2 11.2 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 TrmB PF01978.19 EFE38623.1 - 0.094 12.6 0.2 18 5.3 0.0 2.4 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB COG4 PF08318.12 EFE38624.1 - 5.6e-16 58.5 0.1 7.8e-16 58.1 0.1 1.2 1 0 0 1 1 1 1 COG4 transport protein JmjC PF02373.22 EFE38625.1 - 5.9e-09 36.4 0.0 6.8e-08 32.9 0.0 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 EFE38625.1 - 4.2e-08 32.9 8.2 4.2e-08 32.9 8.2 2.5 3 0 0 3 3 3 1 PHD-finger Cupin_8 PF13621.6 EFE38625.1 - 1.6e-07 31.3 1.4 2e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 Cupin-like domain JHD PF17811.1 EFE38625.1 - 1.2e-06 29.0 0.3 2.2e-06 28.1 0.3 1.4 1 0 0 1 1 1 1 Jumonji helical domain PHD_2 PF13831.6 EFE38625.1 - 4.1 7.0 9.7 3.2 7.4 7.5 2.1 2 0 0 2 2 2 0 PHD-finger RRM_1 PF00076.22 EFE38626.1 - 1e-32 111.8 0.4 2.7e-15 55.9 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFE38626.1 - 1.1e-10 41.4 0.3 0.00064 19.8 0.1 3.0 2 2 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 EFE38626.1 - 0.0029 17.6 0.1 2.1 8.4 0.0 2.7 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 EFE38626.1 - 0.011 15.8 0.1 5.2 7.1 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Phytochelatin PF05023.14 EFE38626.1 - 0.053 12.7 0.7 1.4 8.1 0.0 2.8 3 0 0 3 3 3 0 Phytochelatin synthase LOH1CR12 PF10158.9 EFE38626.1 - 0.83 9.7 4.3 2.4 8.2 4.3 1.7 1 0 0 1 1 1 0 Tumour suppressor protein CEND1 PF15677.5 EFE38627.1 - 0.4 11.2 12.0 0.55 10.8 12.0 1.2 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 SOG2 PF10428.9 EFE38627.1 - 3 7.0 12.0 3.6 6.7 12.0 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein CCDC53 PF10152.9 EFE38627.1 - 5.2 7.5 9.3 7.7 6.9 9.3 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex RabGAP-TBC PF00566.18 EFE38628.1 - 9.1e-47 159.5 0.0 4.2e-46 157.3 0.0 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain RrnaAD PF00398.20 EFE38629.1 - 7.1e-56 189.2 0.2 2e-30 105.8 0.0 2.2 1 1 1 2 2 2 2 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EFE38629.1 - 1e-05 26.1 0.0 2.3e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFE38629.1 - 0.00031 20.5 0.0 0.00055 19.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 EFE38629.1 - 0.00037 21.1 0.0 0.00092 19.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFE38629.1 - 0.0004 19.8 0.1 0.00065 19.1 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EFE38629.1 - 0.0011 18.8 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38629.1 - 0.01 16.6 0.0 0.052 14.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Met_10 PF02475.16 EFE38629.1 - 0.025 14.3 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_28 PF02636.17 EFE38629.1 - 0.035 13.7 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 EFE38629.1 - 0.035 13.4 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DREV PF05219.12 EFE38629.1 - 0.048 12.7 0.0 0.079 12.0 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_4 PF02390.17 EFE38629.1 - 0.05 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.13 EFE38629.1 - 0.093 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFE38629.1 - 0.093 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.7 EFE38629.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PRP1_N PF06424.12 EFE38630.1 - 9.2e-54 181.9 7.9 2.4e-53 180.5 7.9 1.8 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EFE38630.1 - 7.2e-29 98.0 26.6 0.0038 17.9 0.1 14.3 5 4 10 15 15 14 7 Tetratricopeptide repeat TPR_19 PF14559.6 EFE38630.1 - 5.1e-26 91.0 7.2 1.2e-06 29.0 0.1 9.7 6 3 2 9 9 9 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFE38630.1 - 3.9e-10 39.1 9.8 0.27 11.4 0.0 8.9 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFE38630.1 - 1.4e-08 34.3 3.0 0.093 13.0 0.0 7.8 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFE38630.1 - 1.5e-08 34.5 1.7 2.6 8.6 0.0 8.8 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFE38630.1 - 6e-07 30.0 14.1 0.22 12.2 0.0 7.6 7 1 1 8 8 8 1 Tetratricopeptide repeat NARP1 PF12569.8 EFE38630.1 - 8.4e-07 28.3 8.4 0.0099 14.8 0.0 5.5 4 1 2 6 6 6 1 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 EFE38630.1 - 1.1e-05 25.5 3.8 0.043 14.0 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFE38630.1 - 0.00017 21.2 1.3 33 4.3 0.0 6.6 7 1 1 8 8 8 0 TPR repeat TPR_1 PF00515.28 EFE38630.1 - 0.00026 20.7 1.6 0.88 9.5 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat ZNRF_3_ecto PF18212.1 EFE38630.1 - 0.011 15.8 0.2 35 4.5 0.0 4.6 6 0 0 6 6 6 0 ZNRF-3 Ectodomain TPR_12 PF13424.6 EFE38630.1 - 0.022 15.0 5.5 20 5.6 0.1 6.3 7 1 0 7 7 7 0 Tetratricopeptide repeat DUF3808 PF10300.9 EFE38630.1 - 0.099 11.4 0.3 3.4 6.3 0.0 3.4 3 1 0 4 4 4 0 Protein of unknown function (DUF3808) AdenylateSensor PF16579.5 EFE38630.1 - 0.12 12.8 0.6 25 5.4 0.0 3.7 3 1 1 4 4 4 0 Adenylate sensor of SNF1-like protein kinase TPR_7 PF13176.6 EFE38630.1 - 0.32 11.1 2.4 1.1e+02 3.2 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 EFE38630.1 - 0.46 10.2 21.4 1.1 8.9 0.1 4.7 3 1 1 5 5 5 0 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 EFE38630.1 - 7.2 7.5 12.8 53 4.7 0.0 6.9 9 0 0 9 9 6 0 Tetratricopeptide repeat SAGA-Tad1 PF12767.7 EFE38631.1 - 2.1e-50 171.7 0.0 1.2e-41 143.1 0.0 2.1 2 0 0 2 2 2 2 Transcriptional regulator of RNA polII, SAGA, subunit FUSC_2 PF13515.6 EFE38632.1 - 7.9e-32 110.1 10.4 7.9e-32 110.1 10.4 2.5 2 1 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 EFE38632.1 - 4.9e-06 25.4 19.8 0.00014 20.6 15.8 3.1 2 1 0 2 2 2 2 Fusaric acid resistance protein family ArAE_2 PF10334.9 EFE38632.1 - 0.00037 20.4 1.0 0.00093 19.1 0.2 1.9 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 ALMT PF11744.8 EFE38632.1 - 0.00072 18.5 22.3 0.048 12.5 10.6 3.9 4 1 0 4 4 4 2 Aluminium activated malate transporter YajC PF02699.15 EFE38632.1 - 0.052 13.4 0.4 0.16 11.8 0.4 1.8 1 0 0 1 1 1 0 Preprotein translocase subunit FUSC-like PF12805.7 EFE38632.1 - 2.8 7.0 13.3 2.9 6.9 0.0 3.3 3 0 0 3 3 3 0 FUSC-like inner membrane protein yccS Alk_phosphatase PF00245.20 EFE38633.1 - 7.1e-107 357.9 0.1 8.5e-107 357.7 0.1 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EFE38633.1 - 6.1e-07 29.1 0.1 2.9e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 Metalloenzyme superfamily Methyltransf_2 PF00891.18 EFE38636.1 - 1.9e-19 69.8 0.1 2.9e-19 69.2 0.1 1.4 1 1 0 1 1 1 1 O-methyltransferase domain DUF3328 PF11807.8 EFE38637.1 - 8e-36 123.9 3.9 9.8e-36 123.6 3.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MFS_1 PF07690.16 EFE38640.1 - 8.1e-27 94.1 38.3 8.1e-27 94.1 38.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_M36 PF02128.15 EFE38642.1 - 1.1e-155 518.4 4.2 1.3e-155 518.1 4.2 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EFE38642.1 - 9e-18 63.8 4.3 1.8e-17 62.9 4.3 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 EFE38642.1 - 0.085 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain VAR1 PF05316.12 EFE38642.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein (VAR1) WD40 PF00400.32 EFE38645.1 - 1.3e-35 120.7 27.6 5.1e-05 23.9 0.2 11.0 11 1 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE38645.1 - 2.5e-19 69.3 4.0 0.00027 21.2 0.0 6.4 4 2 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE38645.1 - 0.0015 17.6 0.2 27 3.6 0.0 4.5 4 2 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EFE38645.1 - 0.0033 17.3 0.8 24 5.0 0.0 4.7 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat BBS2_N PF14781.6 EFE38645.1 - 0.0066 16.3 0.0 0.17 11.8 0.0 2.6 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, N-terminal PPR_2 PF13041.6 EFE38647.1 - 5.6e-11 42.5 0.4 0.0044 17.2 0.0 6.3 6 2 2 8 8 8 3 PPR repeat family PPR PF01535.20 EFE38647.1 - 2.4e-05 24.3 4.9 1.6 9.1 0.0 6.7 7 0 0 7 7 7 1 PPR repeat DDT PF02791.17 EFE38647.1 - 0.029 14.7 0.3 0.28 11.5 0.1 2.6 2 0 0 2 2 2 0 DDT domain PPR_long PF17177.4 EFE38647.1 - 0.038 13.4 0.2 0.13 11.6 0.0 2.1 3 0 0 3 3 3 0 Pentacotripeptide-repeat region of PRORP Myb_DNA-binding PF00249.31 EFE38648.1 - 5.1e-30 103.4 4.4 2e-09 37.5 0.4 3.3 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFE38648.1 - 4.1e-24 84.6 0.5 6.4e-13 48.7 0.2 3.2 1 1 2 3 3 3 3 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFE38648.1 - 0.00016 21.8 1.1 0.14 12.3 0.2 2.9 2 1 1 3 3 3 2 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 EFE38648.1 - 0.0014 18.5 0.1 0.49 10.3 0.0 2.6 2 1 1 3 3 3 2 Myb DNA-binding like Rap1_C PF11626.8 EFE38648.1 - 0.025 14.6 1.2 7.5 6.7 0.1 2.6 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain RAP80_UIM PF18282.1 EFE38648.1 - 0.2 11.4 0.6 0.44 10.4 0.1 1.8 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif MFS_1 PF07690.16 EFE38649.1 - 2.7e-55 187.7 74.7 1.5e-46 158.9 47.6 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFE38649.1 - 0.04 12.8 28.2 0.0074 15.2 8.5 2.4 2 0 0 2 2 2 0 MFS_1 like family ELFV_dehydrog PF00208.21 EFE38650.1 - 1.1e-60 205.4 0.0 1.6e-60 204.9 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EFE38650.1 - 7e-21 73.6 0.2 2.2e-14 52.1 0.0 2.4 3 0 0 3 3 3 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EFE38650.1 - 0.14 12.1 0.0 0.67 9.8 0.0 2.0 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DUF4017 PF13209.6 EFE38651.1 - 0.029 14.3 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4017) FAM70 PF14967.6 EFE38651.1 - 1.7 8.1 7.6 2.3 7.6 7.6 1.1 1 0 0 1 1 1 0 FAM70 protein TFIIIC_sub6 PF10419.9 EFE38652.1 - 9.7e-27 92.7 0.0 2.2e-26 91.5 0.0 1.6 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain DUF678 PF05077.12 EFE38652.1 - 3.2 7.9 8.8 2 8.6 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF678) TRP PF06011.12 EFE38653.1 - 4e-139 464.0 9.0 5.5e-139 463.6 9.0 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EFE38653.1 - 4.9e-32 111.2 0.4 8e-32 110.5 0.4 1.4 1 0 0 1 1 1 1 ML-like domain Pox_A14 PF05767.12 EFE38653.1 - 0.091 12.9 0.1 0.091 12.9 0.1 3.2 2 1 2 4 4 4 0 Poxvirus virion envelope protein A14 Hep_59 PF07052.11 EFE38654.1 - 5.9e-08 33.4 0.2 5.9e-08 33.4 0.2 2.8 3 2 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 p450 PF00067.22 EFE38655.1 - 1.3e-50 172.5 0.0 2.5e-50 171.6 0.0 1.4 2 0 0 2 2 2 1 Cytochrome P450 DUF3323 PF11796.8 EFE38656.1 - 0.0025 17.7 0.1 0.003 17.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function N-terminus (DUF3323) Rab_eff_C PF04698.12 EFE38656.1 - 0.013 13.8 0.3 0.017 13.4 0.3 1.1 1 0 0 1 1 1 0 Rab effector MyRIP/melanophilin C-terminus Tetraspanin PF00335.20 EFE38656.1 - 0.02 14.6 0.2 0.025 14.3 0.2 1.1 1 0 0 1 1 1 0 Tetraspanin family Pkinase PF00069.25 EFE38658.1 - 6.7e-65 219.1 0.0 8.8e-65 218.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38658.1 - 1.5e-30 106.4 0.0 1.1e-29 103.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFE38658.1 - 8.1e-05 22.1 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFE38658.1 - 0.0036 16.6 0.6 0.058 12.7 0.0 2.6 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 EFE38658.1 - 0.0088 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFE38658.1 - 0.014 14.3 0.0 0.024 13.6 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EFE38658.1 - 0.096 12.3 0.2 4.5 6.8 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF4360 PF14273.6 EFE38659.1 - 3.7e-51 173.5 0.9 4.2e-51 173.3 0.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) BTB PF00651.31 EFE38660.1 - 0.091 13.0 0.1 0.27 11.5 0.0 1.7 2 0 0 2 2 2 0 BTB/POZ domain Pneumovirus_M2 PF06436.11 EFE38660.1 - 0.096 12.2 0.2 0.17 11.3 0.2 1.3 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) CHDCT2 PF08074.11 EFE38660.1 - 0.19 11.9 0.1 0.44 10.7 0.0 1.6 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain Sugar_tr PF00083.24 EFE38661.1 - 2.9e-89 300.0 27.4 3.5e-77 260.2 14.6 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFE38661.1 - 2.5e-15 56.3 28.3 2.5e-15 56.3 28.3 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EFE38661.1 - 2e-05 23.1 0.8 2e-05 23.1 0.8 2.6 3 0 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family DUF3464 PF11947.8 EFE38661.1 - 0.092 12.5 2.2 0.25 11.1 2.2 1.7 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 zf-CCHC PF00098.23 EFE38662.1 - 1.7e-10 40.5 34.0 5.7e-06 26.2 1.8 5.4 6 0 0 6 6 6 3 Zinc knuckle HIGH_NTase1_ass PF16581.5 EFE38662.1 - 0.16 11.9 0.1 0.26 11.3 0.1 1.3 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region zf-CCHC_4 PF14392.6 EFE38662.1 - 0.16 11.7 17.6 0.24 11.1 0.4 3.9 3 1 0 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 EFE38662.1 - 0.18 11.8 16.9 4.5 7.3 7.3 4.1 2 1 1 3 3 3 0 Zinc knuckle Copper-fist PF00649.18 EFE38662.1 - 1.9 8.1 23.0 0.14 11.7 4.2 4.0 2 1 2 4 4 4 0 Copper fist DNA binding domain zf-CCHC_2 PF13696.6 EFE38662.1 - 6.3 6.7 24.6 0.62 9.9 2.0 4.0 4 0 0 4 4 4 0 Zinc knuckle DUF846 PF05832.12 EFE38663.1 - 7.7e-39 132.9 6.6 9.2e-39 132.7 6.6 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Acyl-CoA_dh_1 PF00441.24 EFE38664.1 - 3e-31 108.7 0.1 4.1e-31 108.2 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFE38664.1 - 3e-22 78.6 0.1 5.2e-22 77.9 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EFE38664.1 - 3.4e-18 66.4 0.0 5.1e-17 62.6 0.0 2.4 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EFE38664.1 - 0.002 18.4 0.0 0.0028 17.9 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ECH_1 PF00378.20 EFE38665.1 - 9.3e-49 166.0 0.0 1.2e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFE38665.1 - 9.8e-24 84.4 0.1 1.5e-21 77.3 0.0 2.2 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase HpcH_HpaI PF03328.14 EFE38666.1 - 3.1e-42 144.2 0.1 3e-41 141.0 0.0 2.2 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EFE38666.1 - 1e-12 47.9 1.5 8.5e-06 25.2 0.0 2.5 2 1 0 3 3 2 2 C-C_Bond_Lyase of the TIM-Barrel fold GGA_N-GAT PF18308.1 EFE38666.1 - 0.0021 17.6 0.0 0.0047 16.5 0.0 1.5 1 0 0 1 1 1 1 GGA N-GAT domain APG6_N PF17675.1 EFE38666.1 - 0.0027 18.3 6.6 0.0049 17.4 6.6 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region Dor1 PF04124.12 EFE38666.1 - 0.0054 15.5 0.8 0.0085 14.8 0.8 1.2 1 0 0 1 1 1 1 Dor1-like family DUF4201 PF13870.6 EFE38666.1 - 0.0092 15.7 5.6 0.016 15.0 5.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) EzrA PF06160.12 EFE38666.1 - 0.01 14.1 2.9 0.014 13.6 2.9 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA YabA PF06156.13 EFE38666.1 - 0.011 16.3 3.3 0.021 15.4 3.3 1.3 1 0 0 1 1 1 0 Initiation control protein YabA HAP1_N PF04849.13 EFE38666.1 - 0.013 14.7 4.0 0.022 14.0 4.0 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Lsr2 PF11774.8 EFE38666.1 - 0.015 15.4 1.2 0.04 14.1 1.2 1.7 1 0 0 1 1 1 0 Lsr2 TMF_TATA_bd PF12325.8 EFE38666.1 - 0.026 14.8 4.7 0.049 13.9 4.7 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding PK PF00224.21 EFE38666.1 - 0.047 12.6 0.0 0.091 11.6 0.0 1.4 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain COG2 PF06148.11 EFE38666.1 - 0.047 13.8 1.2 0.1 12.7 1.2 1.5 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Sec34 PF04136.15 EFE38666.1 - 0.049 13.5 1.8 0.1 12.5 1.8 1.4 1 0 0 1 1 1 0 Sec34-like family DUF357 PF04010.13 EFE38666.1 - 0.094 12.8 0.2 0.23 11.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF357) COG6 PF06419.11 EFE38666.1 - 0.14 10.3 2.1 0.22 9.7 2.1 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 DivIC PF04977.15 EFE38666.1 - 0.17 11.7 5.3 0.38 10.6 5.3 1.6 1 0 0 1 1 1 0 Septum formation initiator Prominin PF05478.11 EFE38666.1 - 0.17 9.8 0.7 0.24 9.3 0.7 1.1 1 0 0 1 1 1 0 Prominin ZapB PF06005.12 EFE38666.1 - 0.17 12.3 10.5 0.37 11.3 10.5 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DUF1664 PF07889.12 EFE38666.1 - 0.19 11.8 0.8 0.41 10.7 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Synaptobrevin PF00957.21 EFE38666.1 - 0.21 11.4 1.0 0.52 10.1 1.0 1.7 1 0 0 1 1 1 0 Synaptobrevin V-SNARE PF05008.15 EFE38666.1 - 0.22 11.9 5.9 0.43 11.0 5.9 1.5 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus CENP-H PF05837.12 EFE38666.1 - 0.22 11.9 2.7 0.47 10.9 2.7 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF812 PF05667.11 EFE38666.1 - 0.28 10.0 6.6 0.4 9.5 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) UPF0242 PF06785.11 EFE38666.1 - 0.32 11.1 5.0 0.49 10.5 5.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Jnk-SapK_ap_N PF09744.9 EFE38666.1 - 0.36 11.1 9.5 0.65 10.2 9.5 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ATG16 PF08614.11 EFE38666.1 - 0.41 10.8 10.4 0.078 13.2 6.7 1.6 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) OmpH PF03938.14 EFE38666.1 - 0.42 10.9 5.7 0.75 10.1 5.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) GAS PF13851.6 EFE38666.1 - 0.45 9.8 8.6 0.83 9.0 8.6 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DLP_helical PF18709.1 EFE38666.1 - 0.53 9.4 4.7 0.82 8.8 4.7 1.2 1 0 0 1 1 1 0 Dynamin-like helical domain Spc7 PF08317.11 EFE38666.1 - 0.56 9.0 6.9 0.86 8.4 6.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein ERM PF00769.19 EFE38666.1 - 0.77 9.5 11.4 1.2 8.9 11.4 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family V_ATPase_I PF01496.19 EFE38666.1 - 0.81 7.5 2.0 1.2 7.0 2.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EMP24_GP25L PF01105.24 EFE38666.1 - 1.2 9.1 3.6 2 8.3 3.6 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF883 PF05957.13 EFE38666.1 - 2.4 8.8 5.2 0.82 10.3 2.0 1.9 2 0 0 2 2 1 0 Bacterial protein of unknown function (DUF883) YlqD PF11068.8 EFE38666.1 - 3 8.2 8.4 7 7.0 8.4 1.6 1 0 0 1 1 1 0 YlqD protein GrpE PF01025.19 EFE38666.1 - 5.4 6.7 7.7 9.4 5.9 7.7 1.3 1 0 0 1 1 1 0 GrpE DUF1771 PF08590.10 EFE38667.1 - 7.9e-14 51.8 5.0 7.9e-14 51.8 5.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 EFE38667.1 - 2.7e-10 40.5 0.0 1e-09 38.6 0.0 2.1 1 0 0 1 1 1 1 Smr domain zf_CCCH_4 PF18345.1 EFE38667.1 - 6.5e-08 32.4 10.7 7.9e-07 28.9 0.8 3.2 2 1 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 EFE38667.1 - 6.4e-07 29.1 2.3 0.0059 16.5 0.4 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFE38667.1 - 5.6e-06 26.0 11.1 0.00012 21.8 0.8 3.0 2 1 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EFE38667.1 - 0.0008 19.6 4.5 0.22 11.7 0.2 2.7 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.6 EFE38667.1 - 0.00081 19.8 6.1 0.13 12.8 0.9 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger CUE PF02845.16 EFE38667.1 - 0.082 12.6 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 CUE domain DUF5137 PF17220.3 EFE38667.1 - 0.18 12.7 3.5 2.3 9.2 2.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF5137) Glyco_transf_90 PF05686.12 EFE38668.1 - 4.5e-16 58.8 1.8 2.5e-11 43.2 1.0 2.9 2 1 0 2 2 2 2 Glycosyl transferase family 90 Oxidored_molyb PF00174.19 EFE38670.1 - 1.7e-49 167.7 0.0 2.5e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EFE38670.1 - 8.6e-13 48.5 0.0 1.7e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain NAD_binding_1 PF00175.21 EFE38671.1 - 8.5e-27 94.0 0.0 8e-26 90.8 0.0 2.4 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFE38671.1 - 5.1e-25 87.7 0.0 8.3e-25 87.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 EFE38671.1 - 6e-14 51.9 0.6 1.3e-13 50.9 0.1 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EFE38671.1 - 0.00094 19.3 0.4 0.049 13.7 0.1 2.7 2 1 1 3 3 3 1 Ferric reductase NAD binding domain CAP59_mtransfer PF11735.8 EFE38672.1 - 4.9e-84 281.8 0.0 6.4e-84 281.4 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 AICARFT_IMPCHas PF01808.18 EFE38673.1 - 8e-91 304.5 0.0 1.6e-90 303.6 0.0 1.5 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EFE38673.1 - 4.6e-25 87.6 0.0 8.3e-25 86.8 0.0 1.4 1 0 0 1 1 1 1 MGS-like domain DUF346 PF03984.13 EFE38674.1 - 3.6e-59 196.2 62.6 3.9e-10 39.3 0.4 7.2 7 0 0 7 7 7 7 Repeat of unknown function (DUF346) Ntox14 PF15522.6 EFE38674.1 - 6.5e-05 22.4 0.0 46 3.3 0.0 6.2 7 0 0 7 7 7 0 Novel toxin 14 DUF1724 PF08350.10 EFE38674.1 - 0.017 15.2 7.5 4 7.6 0.0 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF1724) DUF2510 PF10708.9 EFE38674.1 - 0.019 14.7 47.5 0.33 10.8 2.9 6.4 6 0 0 6 6 6 0 Protein of unknown function (DUF2510) SNARE_assoc PF09335.11 EFE38675.1 - 1e-05 26.0 9.1 1e-05 26.0 9.1 3.2 2 1 1 3 3 3 1 SNARE associated Golgi protein Amino_oxidase PF01593.24 EFE38676.1 - 3.7e-83 280.3 0.1 6.7e-82 276.2 0.1 2.2 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 EFE38676.1 - 5.8e-14 52.2 0.1 1.8e-13 50.6 0.0 1.9 2 0 0 2 2 2 1 SWIRM domain NAD_binding_8 PF13450.6 EFE38676.1 - 2.4e-07 30.9 0.1 5.1e-07 29.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box PF00505.19 EFE38676.1 - 4.2e-05 23.9 5.3 4.4e-05 23.8 2.6 2.4 2 1 0 2 2 2 1 HMG (high mobility group) box DAO PF01266.24 EFE38676.1 - 0.0032 17.1 0.5 0.0065 16.1 0.5 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFE38676.1 - 0.014 14.7 0.1 0.13 11.4 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFE38677.1 - 4.8e-50 170.5 0.8 5.7e-50 170.2 0.8 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE38677.1 - 5.7e-17 61.9 0.2 2.8e-15 56.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE38677.1 - 2.1e-16 60.2 0.5 9.5e-14 51.7 0.2 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFE38677.1 - 2.8e-05 23.5 0.7 6.5e-05 22.3 0.1 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_7 PF13241.6 EFE38677.1 - 5.2e-05 23.6 0.0 0.013 15.9 0.0 2.6 1 1 1 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 EFE38677.1 - 0.00018 21.6 0.2 0.16 12.2 0.0 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFE38677.1 - 0.0051 16.0 0.1 0.63 9.1 0.0 3.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EFE38677.1 - 0.012 14.9 0.6 2.2 7.5 0.0 2.5 2 1 0 2 2 2 0 FAD binding domain DAO PF01266.24 EFE38677.1 - 0.027 14.1 4.4 0.88 9.1 0.1 3.4 2 2 1 3 3 3 0 FAD dependent oxidoreductase GIDA PF01134.22 EFE38677.1 - 0.028 13.5 4.9 2 7.4 0.1 3.7 3 1 2 5 5 5 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFE38677.1 - 0.033 13.5 0.3 0.11 11.8 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EFE38677.1 - 0.083 12.9 0.2 8.5 6.4 0.0 2.9 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EFE38677.1 - 0.15 11.1 5.2 0.37 9.8 0.3 2.9 2 2 0 2 2 2 0 FAD binding domain Methyltransf_34 PF11312.8 EFE38678.1 - 0.037 13.3 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Putative SAM-dependent methyltransferase APH PF01636.23 EFE38679.1 - 8.3e-15 55.4 0.0 1.3e-14 54.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE38679.1 - 2.8e-10 40.1 0.0 7e-10 38.8 0.0 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase Pkinase PF00069.25 EFE38679.1 - 0.0046 16.4 0.0 0.15 11.4 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain DUF1679 PF07914.11 EFE38679.1 - 0.05 12.5 0.0 0.65 8.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Sulfotransfer_4 PF17784.1 EFE38680.1 - 2.2e-62 210.7 0.4 3.3e-62 210.1 0.4 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EFE38680.1 - 0.44 10.9 3.3 4 7.7 3.3 2.4 1 1 0 1 1 1 0 Sulfotransferase family Trypan_PARP PF05887.11 EFE38682.1 - 0.046 13.7 12.1 0.073 13.1 12.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Peptidase_S8 PF00082.22 EFE38683.1 - 8.9e-33 113.8 2.3 1.5e-32 113.0 2.3 1.4 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EFE38683.1 - 7.8e-29 99.5 0.9 1.5e-28 98.6 0.9 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain Mucin PF01456.17 EFE38683.1 - 1.8 8.5 13.6 3.7 7.5 13.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein PAT1 PF09770.9 EFE38684.1 - 0 1140.3 6.1 0 1140.1 6.1 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 NAD_binding_10 PF13460.6 EFE38685.1 - 3.2e-27 95.6 0.0 3.7e-27 95.4 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFE38685.1 - 1.7e-09 37.6 0.0 2.3e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EFE38685.1 - 4e-07 29.7 0.0 6.4e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFE38685.1 - 8.3e-06 25.0 0.0 1.1e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EFE38685.1 - 0.00042 20.6 0.0 0.00075 19.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EFE38686.1 - 2.8e-42 144.8 0.0 1.9e-24 86.5 0.0 2.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFE38686.1 - 6.4e-39 134.3 0.0 2.3e-21 76.6 0.0 2.7 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFE38686.1 - 2.4e-11 43.2 0.0 4.6e-05 22.6 0.0 2.2 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 EFE38686.1 - 2.2e-09 37.1 0.1 1.2e-08 34.6 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EFE38686.1 - 2.1e-07 30.4 0.1 4.2e-05 22.8 0.0 2.8 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EFE38686.1 - 6.1e-07 29.5 0.0 3.2e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 KR domain RmlD_sub_bind PF04321.17 EFE38686.1 - 3.4e-06 26.4 0.0 0.018 14.2 0.0 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain adh_short_C2 PF13561.6 EFE38686.1 - 6.6e-05 22.6 0.0 0.00023 20.8 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 EFE38686.1 - 0.011 15.3 0.0 0.026 14.1 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family UDPG_MGDP_dh_N PF03721.14 EFE38686.1 - 0.015 14.9 0.1 0.029 14.0 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_4 PF07993.12 EFE38686.1 - 0.016 14.4 0.0 0.95 8.6 0.0 2.4 2 0 0 2 2 2 0 Male sterility protein 3HCDH_N PF02737.18 EFE38686.1 - 0.022 14.7 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 EFE38686.1 - 0.034 14.0 0.0 0.092 12.6 0.0 1.7 1 1 0 1 1 1 0 NAD(P)H-binding adh_short PF00106.25 EFE38687.1 - 1.3e-10 41.1 0.0 3.1e-10 39.8 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EFE38687.1 - 7e-05 22.8 0.0 0.0002 21.3 0.0 1.9 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 EFE38687.1 - 8.4e-05 22.2 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFE38687.1 - 0.026 14.0 0.1 0.04 13.4 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family G-patch PF01585.23 EFE38688.1 - 3.8e-08 33.1 0.2 8.4e-08 32.0 0.2 1.5 1 0 0 1 1 1 1 G-patch domain DUF4287 PF14117.6 EFE38688.1 - 0.11 12.6 0.1 0.22 11.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) Sec1 PF00995.23 EFE38689.1 - 1.8e-111 374.2 0.0 2.1e-111 373.9 0.0 1.1 1 0 0 1 1 1 1 Sec1 family SUV3_C PF12513.8 EFE38690.1 - 2.4e-16 59.4 0.1 4.7e-16 58.4 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 EFE38690.1 - 1.3e-06 28.7 0.0 3e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 EFE38690.1 - 0.0001 22.1 0.0 0.0002 21.2 0.0 1.5 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 DUF4771 PF15995.5 EFE38690.1 - 0.11 12.8 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) HA2 PF04408.23 EFE38691.1 - 1.6e-23 83.0 0.7 4.3e-23 81.7 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFE38691.1 - 2.1e-15 56.9 0.0 4.5e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFE38691.1 - 2.3e-13 50.5 0.0 5.9e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EFE38691.1 - 9.9e-10 38.6 1.7 2.7e-09 37.2 1.7 1.7 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 EFE38691.1 - 0.00029 20.7 0.2 0.00077 19.3 0.2 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EFE38691.1 - 0.0013 17.8 0.0 0.0032 16.6 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EFE38691.1 - 0.025 14.8 0.1 0.079 13.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFE38691.1 - 0.074 13.4 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EFE38691.1 - 0.096 12.8 0.0 0.43 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain Npa1 PF11707.8 EFE38693.1 - 1.3e-91 307.5 0.8 1.3e-91 307.5 0.8 2.1 3 0 0 3 3 3 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EFE38693.1 - 3.5e-56 190.0 0.3 2.2e-55 187.4 0.0 2.5 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 NUC153 PF08159.12 EFE38694.1 - 2.5e-14 52.8 8.3 1.4e-13 50.4 0.2 3.7 3 0 0 3 3 3 2 NUC153 domain ATP-synt_J PF04911.12 EFE38694.1 - 0.087 12.4 0.2 0.42 10.2 0.0 2.1 2 0 0 2 2 2 0 ATP synthase j chain DUF4148 PF13663.6 EFE38694.1 - 0.2 11.9 0.1 0.2 11.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) CLTH PF10607.9 EFE38695.1 - 4e-30 104.7 0.2 5.3e-30 104.3 0.2 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EFE38695.1 - 9.9e-05 22.2 0.0 0.00022 21.1 0.0 1.6 1 0 0 1 1 1 1 LisH PUL PF08324.11 EFE38695.1 - 0.06 12.6 2.2 0.19 11.0 0.7 1.9 1 1 1 2 2 2 0 PUL domain Pyr_redox_2 PF07992.14 EFE38696.1 - 1.2e-35 123.2 0.0 4.3e-35 121.4 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE38696.1 - 2.6e-10 40.7 0.0 5.3e-09 36.5 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EFE38696.1 - 1.4e-05 24.3 0.1 5.1e-05 22.5 0.1 2.1 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EFE38696.1 - 0.0002 21.0 0.3 0.00066 19.4 0.3 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 EFE38696.1 - 0.00032 20.1 0.1 0.00082 18.8 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EFE38696.1 - 0.0012 19.2 0.2 0.01 16.3 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_4 PF12763.7 EFE38696.1 - 0.29 11.1 0.9 3.7 7.6 0.0 2.9 4 0 0 4 4 4 0 Cytoskeletal-regulatory complex EF hand HEAT_2 PF13646.6 EFE38697.1 - 7e-29 100.1 6.6 1.6e-12 47.7 0.6 3.5 2 2 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 EFE38697.1 - 1.5e-20 71.7 1.8 0.0032 18.0 0.0 6.7 7 0 0 7 7 7 5 PBS lyase HEAT-like repeat HEAT PF02985.22 EFE38697.1 - 7.8e-06 25.7 3.4 2.9 8.4 0.0 5.8 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EFE38697.1 - 0.00024 21.5 5.2 0.24 11.9 0.0 4.9 3 2 2 5 5 5 1 HEAT-like repeat Paramyxo_P_V_N PF13825.6 EFE38697.1 - 0.24 10.8 1.7 0.79 9.1 0.1 2.3 3 0 0 3 3 3 0 Paramyxovirus structural protein V/P N-terminus Methyltransf_11 PF08241.12 EFE38698.1 - 1.3e-07 32.2 0.0 0.0013 19.3 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38698.1 - 4e-06 27.4 0.0 0.013 16.2 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EFE38698.1 - 0.071 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Nipped-B_C PF12830.7 EFE38699.1 - 6.3e-47 160.0 10.6 3.2e-46 157.7 1.1 4.0 4 1 1 5 5 5 2 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EFE38699.1 - 1.1e-10 41.5 2.5 1.1e-10 41.5 2.5 3.0 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Cnd3 PF12719.7 EFE38699.1 - 0.00068 18.9 0.4 1.1 8.4 0.1 3.0 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain Cnd1 PF12717.7 EFE38699.1 - 0.00072 19.6 5.2 0.5 10.4 0.4 3.5 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFE38699.1 - 0.0031 17.6 3.4 0.75 10.2 0.3 4.8 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.20 EFE38699.1 - 0.043 12.4 9.6 0.58 8.6 7.2 3.5 2 1 1 3 3 3 0 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 EFE38699.1 - 0.12 13.0 0.8 1.8 9.2 0.1 3.0 1 1 0 2 2 2 0 Vacuolar 14 Fab1-binding region DUF3391 PF11871.8 EFE38699.1 - 1.4 9.4 4.1 9.7 6.7 0.9 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3391) FAM176 PF14851.6 EFE38699.1 - 7.1 6.3 8.1 0.31 10.7 0.4 2.6 3 0 0 3 3 3 0 FAM176 family ETC_C1_NDUFA4 PF04800.12 EFE38700.1 - 8e-33 112.6 2.3 1.3e-32 111.9 2.3 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Orthopox_C10L PF07020.11 EFE38701.1 - 0.019 15.7 2.5 8.5 7.2 0.2 3.3 2 0 0 2 2 2 0 Orthopoxvirus C10L protein MOZ_SAS PF01853.18 EFE38702.1 - 9.2e-79 263.3 0.0 1.4e-78 262.7 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EFE38702.1 - 2.2e-22 78.4 0.3 4.6e-22 77.4 0.3 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EFE38702.1 - 3.5e-17 62.0 0.1 4e-16 58.6 0.0 2.3 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EFE38702.1 - 0.0052 17.2 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE38702.1 - 0.047 13.9 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DUF1918 PF08940.11 EFE38702.1 - 0.077 12.6 0.0 0.29 10.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1918) Myb_Cef PF11831.8 EFE38703.1 - 1.8e-51 175.0 3.5 1.8e-51 175.0 3.5 2.8 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EFE38703.1 - 1.7e-21 76.1 6.1 2.1e-10 40.6 0.7 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFE38703.1 - 1.5e-19 70.0 4.7 1.5e-12 47.6 1.4 2.8 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EFE38703.1 - 0.074 13.1 0.4 1 9.5 0.0 2.7 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Nop53 PF07767.11 EFE38704.1 - 4e-101 339.3 39.3 6.1e-101 338.7 39.3 1.3 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) PA26 PF04636.13 EFE38704.1 - 3.4 6.5 6.1 6.1 5.6 6.1 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) XRN_M PF17846.1 EFE38704.1 - 6 5.7 9.7 11 4.8 9.7 1.5 1 0 0 1 1 1 0 Xrn1 helical domain RNase_T PF00929.24 EFE38705.1 - 2.7e-20 73.6 0.0 7.3e-20 72.2 0.0 1.7 1 1 0 1 1 1 1 Exonuclease RNase_H2_suC PF08615.11 EFE38706.1 - 3e-14 53.4 0.1 7.8e-08 32.6 0.1 2.3 1 1 1 2 2 2 2 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Alk_phosphatase PF00245.20 EFE38707.1 - 3.6e-71 240.3 3.9 2e-70 237.9 3.9 1.9 1 1 0 1 1 1 1 Alkaline phosphatase Sulfatase PF00884.23 EFE38707.1 - 2.7e-07 30.3 2.9 2e-06 27.4 2.8 2.2 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EFE38707.1 - 2e-05 24.4 1.5 3.1e-05 23.7 1.5 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EFE38707.1 - 0.0013 17.4 0.2 0.0022 16.7 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) GPAT_N PF14829.6 EFE38707.1 - 0.028 14.4 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal Metalloenzyme PF01676.18 EFE38707.1 - 0.035 13.5 0.3 0.092 12.1 0.3 1.6 1 0 0 1 1 1 0 Metalloenzyme superfamily DcpS PF05652.12 EFE38708.1 - 1.2e-32 112.8 0.0 2e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 EFE38708.1 - 1.6e-31 109.1 0.3 2.7e-31 108.4 0.3 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding KR PF08659.10 EFE38709.1 - 8.8e-18 64.8 0.0 2.1e-17 63.6 0.0 1.6 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EFE38709.1 - 5.4e-08 32.7 0.0 1e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain ADH_zinc_N PF00107.26 EFE38709.1 - 7.1e-07 29.3 0.0 1.5e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EFE38709.1 - 0.00016 21.2 0.3 0.002 17.6 0.0 2.5 3 0 0 3 3 3 1 short chain dehydrogenase PS-DH PF14765.6 EFE38709.1 - 0.0007 18.9 0.0 0.0017 17.7 0.1 1.6 2 0 0 2 2 2 1 Polyketide synthase dehydratase Peptidase_C12 PF01088.21 EFE38711.1 - 1.7e-49 168.4 0.0 1.9e-49 168.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 MT-A70 PF05063.14 EFE38712.1 - 7e-26 91.2 0.0 1.3e-25 90.3 0.0 1.5 1 0 0 1 1 1 1 MT-A70 PUF PF00806.19 EFE38713.1 - 8.5e-29 97.6 0.0 1.5e-05 24.4 0.0 6.1 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EFE38713.1 - 6.4e-11 41.9 0.0 1.5e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IQ PF00612.27 EFE38714.1 - 0.1 12.4 1.2 0.29 11.0 1.2 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif tRNA-synt_2 PF00152.20 EFE38715.1 - 2.3e-75 253.6 0.0 3.2e-75 253.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFE38715.1 - 6.5e-09 35.7 0.0 1.3e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain YL1 PF05764.13 EFE38717.1 - 6.9e-64 216.3 31.0 6.9e-64 216.3 31.0 2.1 2 1 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 EFE38717.1 - 9.4e-14 50.9 0.4 1.6e-13 50.1 0.4 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Ribosomal_60s PF00428.19 EFE38718.1 - 4.2 8.0 8.9 11 6.7 0.2 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Paf1 PF03985.13 EFE38718.1 - 7.9 5.4 13.7 8.5 5.2 13.7 1.0 1 0 0 1 1 1 0 Paf1 SRP-alpha_N PF04086.13 EFE38718.1 - 9 6.1 25.2 9.6 6.0 25.2 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Fungal_trans PF04082.18 EFE38720.1 - 5e-17 61.8 0.0 1.2e-16 60.6 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE38720.1 - 1.1e-09 38.2 12.7 2.5e-09 37.1 12.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KIAA1430 PF13879.6 EFE38720.1 - 0.34 11.7 2.6 0.73 10.6 2.6 1.4 1 0 0 1 1 1 0 KIAA1430 homologue Thymidylat_synt PF00303.19 EFE38721.1 - 3.2e-105 351.1 0.0 3.6e-105 350.9 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase zf-AN1 PF01428.16 EFE38722.1 - 4.8e-24 84.2 26.1 2.6e-12 46.7 9.5 2.3 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 EFE38722.1 - 0.0049 17.1 5.6 0.0049 17.1 5.6 3.2 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain Transp_Tc5_C PF04236.15 EFE38722.1 - 0.14 12.6 15.0 0.12 12.7 4.0 2.6 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain C1_4 PF07975.12 EFE38722.1 - 6.6 7.1 17.7 3 8.2 7.1 2.8 2 2 0 2 2 2 0 TFIIH C1-like domain Hist_deacetyl PF00850.19 EFE38723.1 - 1.3e-49 169.4 0.0 2.3e-49 168.5 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain R3H-assoc PF13902.6 EFE38724.1 - 9.6e-25 87.5 5.2 9.6e-25 87.5 5.2 1.8 2 0 0 2 2 2 1 R3H-associated N-terminal domain R3H PF01424.22 EFE38724.1 - 0.0059 16.6 0.0 0.13 12.3 0.0 2.5 2 0 0 2 2 2 1 R3H domain PIN_8 PF18476.1 EFE38724.1 - 0.17 11.7 4.0 0.24 11.2 4.0 1.1 1 0 0 1 1 1 0 PIN like domain STAT_int PF02865.17 EFE38724.1 - 0.19 12.2 1.8 0.25 11.8 1.0 1.6 1 1 0 1 1 1 0 STAT protein, protein interaction domain Peptidase_M28 PF04389.17 EFE38725.1 - 9.4e-32 110.3 0.0 1.4e-31 109.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EFE38725.1 - 0.00022 21.0 0.1 0.00041 20.1 0.1 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 DUF1774 PF08611.10 EFE38726.1 - 1.6e-30 105.3 1.3 1.6e-30 105.3 1.3 2.1 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1774) dCMP_cyt_deam_1 PF00383.23 EFE38727.1 - 4e-06 26.6 0.0 5.5e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Chitin_synth_1 PF01644.17 EFE38728.1 - 4.8e-77 257.5 0.0 9e-77 256.6 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EFE38728.1 - 2.4e-28 97.9 0.1 6e-28 96.6 0.1 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EFE38728.1 - 7.4e-24 84.3 3.6 3.4e-21 75.5 0.0 2.2 1 1 1 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EFE38728.1 - 8e-07 29.2 0.3 8e-07 29.2 0.3 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFE38728.1 - 0.073 12.9 0.0 0.17 11.7 0.0 1.6 2 0 0 2 2 2 0 Glycosyltransferase like family 2 AFG1_ATPase PF03969.16 EFE38729.1 - 2e-90 303.3 0.0 3.5e-85 286.1 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 EFE38729.1 - 0.00024 21.5 0.3 0.16 12.4 0.0 3.0 2 2 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EFE38729.1 - 0.0013 18.8 0.0 0.0027 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFE38729.1 - 0.003 18.0 0.0 0.017 15.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFE38729.1 - 0.034 14.4 0.0 0.13 12.5 0.0 2.0 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EFE38729.1 - 0.099 12.7 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 EFE38729.1 - 0.19 11.1 0.0 0.48 9.8 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PX PF00787.24 EFE38730.1 - 1.6e-13 50.6 0.0 2.8e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 PX domain SH3_1 PF00018.28 EFE38730.1 - 3.9e-12 45.6 0.3 2.3e-11 43.1 0.0 2.4 3 0 0 3 3 3 1 SH3 domain PB1 PF00564.24 EFE38730.1 - 1.1e-06 28.5 0.3 2.2e-06 27.5 0.3 1.5 1 0 0 1 1 1 1 PB1 domain SH3_9 PF14604.6 EFE38730.1 - 1.2e-06 28.2 0.6 3.1e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EFE38730.1 - 0.011 15.3 0.0 0.03 14.0 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain IHABP4_N PF16174.5 EFE38730.1 - 0.5 11.0 0.1 0.5 11.0 0.1 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Pex14_N PF04695.13 EFE38730.1 - 2.7 8.7 18.5 6.1 7.5 10.4 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MF_alpha PF04648.12 EFE38731.1 - 0.4 11.0 4.3 1.1 9.6 2.4 2.5 2 0 0 2 2 2 0 Yeast mating factor alpha hormone Nop14 PF04147.12 EFE38732.1 - 3.1e-07 29.0 0.9 3.8e-07 28.8 0.9 1.0 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 EFE38732.1 - 0.00064 18.2 0.9 0.00081 17.8 0.9 1.2 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.12 EFE38732.1 - 0.0054 16.2 8.0 0.0075 15.7 8.0 1.2 1 0 0 1 1 1 1 SDA1 Ferlin_C PF16165.5 EFE38732.1 - 0.053 13.5 0.3 0.053 13.5 0.3 1.8 2 0 0 2 2 2 0 Ferlin C-terminus BSP_II PF05432.11 EFE38732.1 - 1.2 8.7 12.6 1.9 8.1 12.6 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) PBP1_TM PF14812.6 EFE38732.1 - 2 8.8 12.8 4.8 7.6 0.3 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal XAP5 PF04921.14 EFE38732.1 - 2.4 7.9 9.1 3.3 7.5 9.1 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator YL1 PF05764.13 EFE38732.1 - 9.4 6.3 19.9 14 5.7 19.9 1.3 1 1 0 1 1 1 0 YL1 nuclear protein SAC3_GANP PF03399.16 EFE38733.1 - 4.4e-25 88.7 1.7 7.4e-23 81.4 1.7 2.2 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EFE38733.1 - 1.7e-05 24.9 0.2 4.5e-05 23.5 0.2 1.7 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family EAP30 PF04157.16 EFE38735.1 - 3e-45 154.4 2.4 3.9e-45 154.0 2.4 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 EFE38735.1 - 2.6e-22 78.0 1.3 2.6e-22 78.0 1.3 2.7 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Vps36_ESCRT-II PF11605.8 EFE38735.1 - 2.4e-20 72.5 0.0 5.9e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.15 EFE38735.1 - 0.00065 19.7 7.1 0.0025 17.8 0.2 3.3 3 0 0 3 3 3 1 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 EFE38735.1 - 0.0026 17.1 9.5 0.0046 16.3 0.2 2.6 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others GRAM PF02893.20 EFE38735.1 - 0.037 13.9 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 GRAM domain zf-MIZ PF02891.20 EFE38735.1 - 0.045 13.5 0.1 0.11 12.3 0.1 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Cas_CXXC_CXXC PF09706.10 EFE38735.1 - 0.094 13.0 0.2 13 6.1 0.1 2.6 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_CXXC_CXXC) DZR PF12773.7 EFE38735.1 - 8.4 6.5 6.8 3.6 7.7 0.9 2.3 1 1 1 2 2 2 0 Double zinc ribbon LAP1C PF05609.12 EFE38736.1 - 0.0084 15.2 10.7 0.011 14.9 10.7 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) LYRIC PF15686.5 EFE38736.1 - 0.0088 15.6 18.0 0.0088 15.6 18.0 1.8 2 0 0 2 2 2 1 Lysine-rich CEACAM1 co-isolated protein family DUF2201_N PF13203.6 EFE38736.1 - 0.016 14.8 0.1 0.016 14.8 0.1 2.2 1 1 1 2 2 2 0 Putative metallopeptidase domain Serinc PF03348.15 EFE38736.1 - 0.053 12.5 9.2 0.17 10.8 9.3 1.7 1 1 0 1 1 1 0 Serine incorporator (Serinc) Hamartin PF04388.12 EFE38736.1 - 0.41 9.2 12.9 0.51 9.0 12.9 1.0 1 0 0 1 1 1 0 Hamartin protein SAPS PF04499.15 EFE38736.1 - 0.53 9.0 5.1 0.6 8.8 5.1 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SLC12 PF03522.15 EFE38736.1 - 0.56 9.2 9.0 0.73 8.8 9.0 1.3 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 EFE38736.1 - 1.2 8.9 18.2 0.056 13.3 12.4 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4407 PF14362.6 EFE38736.1 - 1.7 7.9 8.2 2.1 7.6 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PA26 PF04636.13 EFE38736.1 - 1.9 7.3 7.0 2.2 7.1 7.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) MCM_bind PF09739.9 EFE38736.1 - 1.9 6.8 15.2 2.9 6.2 15.2 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PigN PF04987.14 EFE38736.1 - 2 7.2 4.9 2.9 6.6 4.8 1.4 1 1 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Spt20 PF12090.8 EFE38736.1 - 2.8 7.5 13.1 4.9 6.7 13.1 1.3 1 0 0 1 1 1 0 Spt20 family MCU PF04678.13 EFE38736.1 - 2.9 8.0 5.3 0.52 10.4 1.2 1.9 2 1 0 2 2 2 0 Mitochondrial calcium uniporter Hid1 PF12722.7 EFE38736.1 - 4.5 5.3 12.4 5.2 5.1 12.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4604 PF15377.6 EFE38736.1 - 5.6 7.3 33.7 0.13 12.6 26.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) AgrB PF04647.15 EFE38736.1 - 5.8 6.2 4.8 0.46 9.8 0.2 1.5 2 0 0 2 2 2 0 Accessory gene regulator B zf-C2H2 PF00096.26 EFE38737.1 - 1.9e-18 65.8 33.8 2.4e-05 24.5 1.8 5.1 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE38737.1 - 5.5e-14 51.9 10.6 8.7e-07 29.1 1.5 5.8 6 0 0 6 6 5 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EFE38737.1 - 1.9e-05 24.8 7.3 0.29 11.5 0.1 5.0 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EFE38737.1 - 0.0001 22.8 19.8 0.0027 18.4 1.2 6.0 6 0 0 6 6 5 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EFE38737.1 - 0.0068 16.6 2.0 1.8 8.6 0.1 2.4 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2_11 PF16622.5 EFE38737.1 - 0.017 14.9 0.7 0.017 14.9 0.7 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type FOXP-CC PF16159.5 EFE38737.1 - 0.096 13.3 0.4 0.096 13.3 0.4 4.7 4 1 1 5 5 5 0 FOXP coiled-coil domain zf-met PF12874.7 EFE38737.1 - 0.11 13.0 19.1 0.2 12.1 0.2 4.7 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Yippee-Mis18 PF03226.14 EFE38737.1 - 0.26 11.5 2.1 12 6.2 0.2 2.5 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-MYST PF17772.1 EFE38737.1 - 0.47 10.1 2.9 4.3 7.0 0.0 3.1 3 0 0 3 3 3 0 MYST family zinc finger domain XPA_N PF01286.18 EFE38737.1 - 1.8 8.7 9.5 0.41 10.7 0.5 3.0 4 0 0 4 4 4 0 XPA protein N-terminal Zn-ribbon_8 PF09723.10 EFE38737.1 - 5.1 7.3 8.9 71 3.6 3.8 3.3 1 1 2 3 3 3 0 Zinc ribbon domain DUF1635 PF07795.11 EFE38737.1 - 7.7 6.3 9.0 19 5.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) C1_4 PF07975.12 EFE38737.1 - 9.1 6.6 7.9 4.2 7.7 0.5 3.1 1 1 2 3 3 3 0 TFIIH C1-like domain Methyltransf_23 PF13489.6 EFE38738.1 - 6.1e-20 71.7 0.0 1.6e-19 70.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE38738.1 - 1.9e-13 50.9 0.0 3.4e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38738.1 - 1.4e-12 48.2 0.1 3.6e-12 46.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38738.1 - 7e-12 45.9 0.0 1.3e-11 45.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38738.1 - 4.5e-09 36.3 0.0 8.3e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF3446 PF11928.8 EFE38738.1 - 0.0069 16.7 4.9 0.018 15.3 4.9 1.8 1 0 0 1 1 1 1 Early growth response N-terminal domain CMAS PF02353.20 EFE38738.1 - 0.008 15.5 0.1 0.71 9.1 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Dscam_C PF12355.8 EFE38738.1 - 0.01 16.8 5.4 0.023 15.7 5.4 1.6 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal Methyltransf_24 PF13578.6 EFE38738.1 - 0.022 15.8 0.0 0.04 14.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Med3 PF11593.8 EFE38738.1 - 0.088 12.0 1.3 0.13 11.4 1.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Spt20 PF12090.8 EFE38738.1 - 0.14 11.7 5.6 2.4 7.7 5.8 2.0 2 0 0 2 2 2 0 Spt20 family NodS PF05401.11 EFE38738.1 - 0.17 11.5 0.0 7.1 6.2 0.0 2.1 2 0 0 2 2 2 0 Nodulation protein S (NodS) Caskin-Pro-rich PF16907.5 EFE38738.1 - 0.85 10.2 8.4 1.8 9.1 8.4 1.6 1 0 0 1 1 1 0 Proline rich region of Caskin proteins PRIMA1 PF16101.5 EFE38738.1 - 0.88 9.6 4.6 1.9 8.6 4.6 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 RCDG1 PF15725.5 EFE38738.1 - 2.5 8.6 12.1 5.8 7.4 12.1 1.6 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein Prp18 PF02840.15 EFE38738.1 - 4.9 7.2 5.1 0.53 10.3 0.2 1.8 2 0 0 2 2 2 0 Prp18 domain DUF4718 PF15842.5 EFE38739.1 - 0.026 14.3 0.0 0.031 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) E1-E2_ATPase PF00122.20 EFE38741.1 - 3.1e-36 124.6 15.6 1.6e-29 102.7 0.5 3.4 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFE38741.1 - 3.5e-28 98.5 3.9 3.5e-28 98.5 3.9 2.4 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EFE38741.1 - 1.2e-23 83.0 0.0 3e-23 81.7 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFE38741.1 - 1.4e-18 67.9 1.6 1.2e-17 65.0 1.6 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFE38741.1 - 2e-14 53.0 0.1 5.1e-14 51.7 0.1 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFE38741.1 - 3.2e-05 23.8 0.7 0.0021 17.8 0.7 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase BRAP2 PF07576.12 EFE38742.1 - 4e-34 116.8 0.0 7.4e-34 115.9 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EFE38742.1 - 1.2e-19 70.4 5.2 1.6e-19 70.0 3.7 2.0 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EFE38742.1 - 1.5e-08 34.8 9.2 1.5e-08 34.8 9.2 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFE38742.1 - 2.3e-06 27.3 8.7 2.3e-06 27.3 8.7 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFE38742.1 - 0.00053 19.7 5.2 0.00053 19.7 5.2 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 EFE38742.1 - 0.0006 19.6 7.7 0.0006 19.6 7.7 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE38742.1 - 0.00077 19.3 5.4 0.00077 19.3 5.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE38742.1 - 0.00077 19.4 7.2 0.00077 19.4 7.2 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EFE38742.1 - 0.00082 19.6 6.4 0.00082 19.6 6.4 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFE38742.1 - 0.0015 18.5 5.6 0.0015 18.5 5.6 2.6 2 1 1 3 3 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EFE38742.1 - 0.0088 16.1 5.3 0.024 14.7 5.3 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger JAKMIP_CC3 PF16034.5 EFE38742.1 - 0.0092 15.9 7.1 0.0092 15.9 7.1 1.7 2 0 0 2 2 1 1 JAKMIP CC3 domain Lectin_N PF03954.14 EFE38742.1 - 0.014 15.1 2.0 0.019 14.7 0.9 1.7 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Prok-RING_4 PF14447.6 EFE38742.1 - 0.017 15.0 5.0 0.017 15.0 5.0 3.4 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 HeLo PF14479.6 EFE38742.1 - 0.041 13.7 5.0 0.065 13.1 5.0 1.3 1 0 0 1 1 1 0 Prion-inhibition and propagation MIP-T3_C PF17749.1 EFE38742.1 - 0.049 13.6 6.1 0.11 12.5 6.1 1.5 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region zf-RING_6 PF14835.6 EFE38742.1 - 0.065 13.1 7.9 0.023 14.6 4.7 2.0 1 1 0 1 1 1 0 zf-RING of BARD1-type protein ZapB PF06005.12 EFE38742.1 - 0.12 12.8 0.4 0.12 12.8 0.4 2.5 1 1 1 2 2 2 0 Cell division protein ZapB ERM PF00769.19 EFE38742.1 - 0.26 11.1 19.8 0.017 15.0 14.3 1.7 2 0 0 2 2 2 0 Ezrin/radixin/moesin family TerY_C PF15616.6 EFE38742.1 - 0.41 10.8 10.6 1.5 8.9 1.5 2.5 1 1 1 2 2 2 0 TerY-C metal binding domain TolA_bind_tri PF16331.5 EFE38742.1 - 0.89 9.7 6.8 2.2 8.4 0.8 2.4 1 1 1 2 2 2 0 TolA binding protein trimerisation ATG16 PF08614.11 EFE38742.1 - 1.2 9.4 19.3 0.13 12.4 12.3 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) zf-RING_4 PF14570.6 EFE38742.1 - 1.5 8.6 6.2 5.1 7.0 6.2 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain GIT_CC PF16559.5 EFE38742.1 - 1.7 8.5 4.3 0.98 9.3 0.7 2.2 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor TPR_MLP1_2 PF07926.12 EFE38742.1 - 1.8 8.6 20.4 0.44 10.6 17.1 1.6 2 0 0 2 2 1 0 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.5 EFE38742.1 - 3.6 8.5 11.9 3.4 8.6 9.6 2.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain UPF0242 PF06785.11 EFE38742.1 - 4.3 7.4 9.1 6 6.9 8.2 1.7 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus APH PF01636.23 EFE38743.1 - 6e-16 59.1 0.0 1.3e-15 58.0 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EFE38743.1 - 0.0013 18.2 0.0 0.007 15.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Choline_kinase PF01633.20 EFE38743.1 - 0.0095 15.5 0.0 0.023 14.3 0.0 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase ubiquitin PF00240.23 EFE38744.1 - 1.5e-89 293.7 12.2 7.2e-33 112.2 0.7 3.4 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 EFE38744.1 - 4.3e-41 138.6 9.7 5.5e-15 55.0 0.8 3.3 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFE38744.1 - 9.4e-15 54.9 5.8 0.00046 20.6 0.2 4.0 3 2 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 EFE38744.1 - 2.1e-11 43.6 0.7 0.043 13.8 0.1 3.5 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EFE38744.1 - 1.7e-08 34.9 0.8 0.31 11.6 0.1 3.4 1 1 2 3 3 3 3 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFE38744.1 - 3.5e-08 33.5 1.4 0.093 12.8 0.1 3.7 2 2 1 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFE38744.1 - 4.4e-08 33.4 3.3 0.07 13.5 0.1 3.3 3 0 0 3 3 3 2 Ubiquitin-like domain DUF3861 PF12977.7 EFE38744.1 - 0.00053 20.1 1.8 8.8 6.6 0.0 3.4 3 0 0 3 3 3 1 Domain of Unknown Function with PDB structure (DUF3861) Big_7 PF17957.1 EFE38744.1 - 0.0034 18.1 0.8 30 5.5 0.1 3.3 3 0 0 3 3 3 0 Bacterial Ig domain Ubiquitin_4 PF18036.1 EFE38744.1 - 0.0051 16.8 11.5 22 5.2 0.1 5.2 5 0 0 5 5 5 0 Ubiquitin-like domain DUF2870 PF11069.8 EFE38744.1 - 0.012 16.0 0.0 5.5 7.5 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) ACT_5 PF13710.6 EFE38744.1 - 0.015 15.1 3.9 13 5.7 0.2 3.6 3 0 0 3 3 3 0 ACT domain NEAT PF05031.12 EFE38744.1 - 0.044 14.4 3.0 0.95 10.1 1.0 2.5 1 1 1 2 2 2 0 Iron Transport-associated domain SH3_16 PF18348.1 EFE38744.1 - 0.051 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain DUF493 PF04359.14 EFE38744.1 - 0.12 13.0 0.1 1.8e+02 2.8 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF493) UDP-g_GGTase PF06427.11 EFE38744.1 - 0.13 12.4 2.5 12 6.1 0.0 3.7 4 0 0 4 4 4 0 UDP-glucose:Glycoprotein Glucosyltransferase YcgR_2 PF12945.7 EFE38744.1 - 0.15 12.3 3.0 73 3.6 0.1 3.3 3 0 0 3 3 3 0 Flagellar protein YcgR ACT_4 PF13291.6 EFE38744.1 - 0.17 12.5 0.8 1.4e+02 3.1 0.0 3.3 3 0 0 3 3 3 0 ACT domain Tash_PEST PF07708.11 EFE38744.1 - 1.1 9.5 18.4 9.4 6.5 1.4 3.4 3 0 0 3 3 3 0 Tash protein PEST motif FlgD_ig PF13860.6 EFE38744.1 - 5.2 7.0 5.6 1e+02 2.8 0.2 3.3 3 0 0 3 3 3 0 FlgD Ig-like domain DUF2631 PF10939.8 EFE38746.1 - 0.13 12.1 0.4 0.33 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2631) Cupin_1 PF00190.22 EFE38747.1 - 7.9e-33 113.2 0.0 7.7e-17 61.3 0.0 2.3 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EFE38747.1 - 1.8e-19 69.2 0.6 8e-11 41.5 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EFE38747.1 - 6.8e-06 25.7 0.1 0.011 15.4 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Sec62 PF03839.16 EFE38750.1 - 8.1e-74 247.8 0.6 8.1e-74 247.8 0.6 2.6 2 1 1 3 3 3 1 Translocation protein Sec62 Zip PF02535.22 EFE38750.1 - 5.5e-06 25.8 0.4 0.083 12.1 0.0 2.3 2 0 0 2 2 2 2 ZIP Zinc transporter DUF4834 PF16118.5 EFE38750.1 - 0.022 15.7 10.7 25 5.9 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DDHD PF02862.17 EFE38750.1 - 0.97 9.5 12.0 0.15 12.2 4.9 2.2 2 0 0 2 2 2 0 DDHD domain Neur_chan_memb PF02932.16 EFE38750.1 - 1.4 8.9 12.2 43 4.0 11.3 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ipi1_N PF12333.8 EFE38750.1 - 1.4 9.5 4.3 6 7.5 0.0 2.6 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation MPM1 PF17234.2 EFE38750.1 - 4.9 7.4 17.3 10 6.4 0.6 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Lectin_C PF00059.21 EFE38751.1 - 0.00032 21.4 1.2 0.0011 19.7 0.3 2.3 2 0 0 2 2 2 1 Lectin C-type domain TMCO5 PF14992.6 EFE38753.1 - 0.0087 15.7 0.1 0.02 14.5 0.1 1.6 1 1 0 1 1 1 1 TMCO5 family DUF2046 PF09755.9 EFE38753.1 - 0.0097 15.2 2.5 0.031 13.5 0.4 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) SlyX PF04102.12 EFE38753.1 - 0.021 15.4 8.3 2 9.1 0.2 2.4 2 0 0 2 2 2 0 SlyX Jnk-SapK_ap_N PF09744.9 EFE38753.1 - 0.028 14.6 5.6 0.52 10.5 0.2 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Cnn_1N PF07989.11 EFE38753.1 - 0.1 12.7 3.0 0.23 11.6 0.0 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 LRRFIP PF09738.9 EFE38753.1 - 0.33 10.4 0.0 0.33 10.4 0.0 3.1 2 2 1 3 3 3 0 LRRFIP family DUF3450 PF11932.8 EFE38753.1 - 0.37 10.1 9.9 0.34 10.2 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Fib_alpha PF08702.10 EFE38753.1 - 0.47 10.6 3.5 6.4 7.0 0.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GIT_CC PF16559.5 EFE38753.1 - 0.5 10.3 12.8 1.2 9.0 0.7 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF2968 PF11180.8 EFE38753.1 - 0.52 9.9 13.4 0.17 11.5 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) Atg14 PF10186.9 EFE38753.1 - 0.87 8.6 7.4 0.75 8.8 2.8 2.5 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Siah-Interact_N PF09032.11 EFE38753.1 - 1.3 9.4 6.6 0.45 10.8 1.7 2.3 2 0 0 2 2 2 0 Siah interacting protein, N terminal Spc24 PF08286.11 EFE38753.1 - 2.6 8.3 5.9 23 5.3 0.1 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Carn_acyltransf PF00755.20 EFE38754.1 - 6.5e-209 695.4 0.0 7.4e-209 695.2 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Rxt3 PF08642.10 EFE38755.1 - 2.3e-46 157.7 0.0 5.8e-46 156.4 0.0 1.7 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 EFE38755.1 - 9.2e-05 22.5 0.0 0.0019 18.3 0.0 2.3 2 0 0 2 2 2 1 LCCL domain SOG2 PF10428.9 EFE38757.1 - 2.8 7.1 16.3 3.2 6.9 16.3 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein CLN3 PF02487.17 EFE38758.1 - 4.3e-162 539.7 1.1 5e-162 539.5 1.1 1.0 1 0 0 1 1 1 1 CLN3 protein Abhydrolase_3 PF07859.13 EFE38759.1 - 5.4e-33 114.6 0.0 1.8e-22 80.2 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Lipase_3 PF01764.25 EFE38759.1 - 0.15 11.9 0.0 0.39 10.6 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Say1_Mug180 PF10340.9 EFE38759.1 - 0.16 10.8 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Aminotran_3 PF00202.21 EFE38760.1 - 1.9e-107 359.5 0.0 2.2e-107 359.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EFE38760.1 - 3e-05 23.4 0.0 0.00012 21.4 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II HMGL-like PF00682.19 EFE38761.1 - 1.6e-43 149.2 0.0 1.9e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 HMGL-like PE PF00934.20 EFE38761.1 - 0.08 13.3 0.9 0.18 12.1 0.2 2.1 2 0 0 2 2 2 0 PE family Diphthamide_syn PF01866.17 EFE38762.1 - 5.7e-119 397.1 0.0 7.7e-119 396.6 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein BSP_II PF05432.11 EFE38762.1 - 0.088 12.5 10.5 0.13 12.0 10.5 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CDC27 PF09507.10 EFE38762.1 - 5.5 6.3 11.4 7.4 5.8 11.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Bromodomain PF00439.25 EFE38763.1 - 1.3e-06 28.4 0.0 0.0002 21.3 0.0 2.4 2 0 0 2 2 2 2 Bromodomain Ribosomal_60s PF00428.19 EFE38763.1 - 5.3 7.7 13.7 4.8 7.9 6.2 3.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein ATG16 PF08614.11 EFE38764.1 - 0.015 15.5 1.0 0.015 15.5 1.0 1.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Sugarporin_N PF11471.8 EFE38764.1 - 0.05 13.6 2.7 0.094 12.7 2.7 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension OSCP PF00213.18 EFE38765.1 - 6.4e-45 153.3 1.8 8.9e-45 152.9 1.8 1.2 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Mob1_phocein PF03637.17 EFE38766.1 - 1.2e-72 243.4 0.1 1.5e-72 243.1 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family Rgp1 PF08737.10 EFE38767.1 - 1.4e-135 452.7 0.0 2.5e-135 451.9 0.0 1.4 1 0 0 1 1 1 1 Rgp1 Arrestin_N PF00339.29 EFE38767.1 - 2.1e-05 24.6 0.0 5.8e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EFE38767.1 - 0.00088 19.7 0.1 0.27 11.7 0.0 3.1 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Neugrin PF06413.11 EFE38768.1 - 1.4e-09 38.3 0.9 2.4e-09 37.6 0.9 1.4 1 0 0 1 1 1 1 Neugrin MRP-L20 PF12824.7 EFE38768.1 - 1.3e-06 28.7 10.8 3.1e-06 27.4 10.8 1.7 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_DeoR PF08220.12 EFE38768.1 - 0.042 13.6 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain BTG PF07742.12 EFE38768.1 - 0.11 12.4 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 BTG family ICMT PF04140.14 EFE38769.1 - 1.6e-29 102.1 0.2 1.6e-29 102.1 0.2 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EFE38769.1 - 1.9e-11 44.3 2.6 1.9e-11 44.3 2.6 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EFE38769.1 - 2.1e-05 24.2 0.5 3.4e-05 23.5 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PQ-loop PF04193.14 EFE38769.1 - 0.22 11.3 0.1 0.22 11.3 0.1 2.9 4 0 0 4 4 4 0 PQ loop repeat Cwf_Cwc_15 PF04889.12 EFE38771.1 - 5.9e-51 173.6 17.5 7.2e-51 173.3 17.5 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein MFAP1 PF06991.11 EFE38771.1 - 0.047 13.5 14.5 0.061 13.2 14.5 1.4 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing SDA1 PF05285.12 EFE38771.1 - 0.094 12.1 17.1 0.1 12.0 17.1 1.1 1 0 0 1 1 1 0 SDA1 PA26 PF04636.13 EFE38771.1 - 2 7.3 4.2 2.4 7.0 4.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Phostensin_N PF13916.6 EFE38771.1 - 4.1 7.8 11.3 11 6.5 7.0 2.3 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal Hid1 PF12722.7 EFE38771.1 - 6.7 4.7 6.2 7.4 4.6 6.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Glyco_hydro_16 PF00722.21 EFE38772.1 - 6.1e-08 32.3 0.2 5.7e-07 29.2 0.0 1.9 1 1 1 2 2 2 1 Glycosyl hydrolases family 16 Glyco_trans_2_3 PF13632.6 EFE38774.1 - 1.5e-48 165.4 0.4 1.5e-48 165.4 0.4 2.8 2 1 1 3 3 3 2 Glycosyl transferase family group 2 WSC PF01822.19 EFE38775.1 - 2.4e-36 123.8 33.9 1.5e-18 66.7 12.8 2.7 3 0 0 3 3 3 2 WSC domain peroxidase PF00141.23 EFE38775.1 - 9.5e-23 81.1 0.2 1.9e-22 80.1 0.2 1.4 1 0 0 1 1 1 1 Peroxidase Flg_new PF09479.10 EFE38775.1 - 0.0017 18.5 2.0 0.016 15.4 0.1 3.3 3 0 0 3 3 3 1 Listeria-Bacteroides repeat domain (List_Bact_rpt) PSI_PSAK PF01241.18 EFE38775.1 - 0.033 14.2 0.3 0.13 12.3 0.0 2.2 2 0 0 2 2 2 0 Photosystem I psaG / psaK ABC_membrane PF00664.23 EFE38777.1 - 4.7e-77 259.3 40.5 2.2e-43 148.9 18.2 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE38777.1 - 2e-29 102.9 0.0 2.9e-26 92.6 0.0 3.4 2 1 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EFE38777.1 - 2.6e-07 30.3 2.2 1.7e-05 24.4 2.2 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFE38777.1 - 0.00012 22.0 0.7 0.00026 20.8 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 EFE38777.1 - 0.00028 20.9 0.0 0.00066 19.7 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EFE38777.1 - 0.00075 19.8 1.3 0.0059 16.9 0.0 2.7 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 EFE38777.1 - 0.0022 17.9 0.0 0.0062 16.5 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFE38777.1 - 0.005 16.6 0.1 0.013 15.2 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFE38777.1 - 0.023 14.5 0.0 0.094 12.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFE38777.1 - 0.028 14.9 0.1 0.028 14.9 0.1 3.2 2 1 1 3 3 1 0 AAA domain AAA_16 PF13191.6 EFE38777.1 - 0.029 14.8 0.0 0.13 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 EFE38777.1 - 0.032 14.7 0.0 7 7.1 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EFE38777.1 - 0.048 13.2 0.1 0.12 12.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFE38777.1 - 0.06 13.9 0.1 0.15 12.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFE38777.1 - 0.12 12.4 0.1 0.94 9.5 0.1 2.4 2 0 0 2 2 2 0 AAA domain Peptidase_S49_N PF08496.10 EFE38777.1 - 1.9 8.5 10.4 0.35 10.9 0.3 2.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal NAD_binding_2 PF03446.15 EFE38778.1 - 3.1e-35 121.7 0.0 4.6e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFE38778.1 - 9.4e-27 93.7 0.0 1.5e-26 93.1 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EFE38778.1 - 7.1e-07 29.7 0.0 2.1e-06 28.2 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EFE38778.1 - 0.00019 20.8 0.0 0.00032 20.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EFE38778.1 - 0.0016 19.3 0.0 0.0032 18.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold MMS1_N PF10433.9 EFE38779.1 - 4.3e-122 408.2 0.0 8.6e-122 407.2 0.0 1.5 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EFE38779.1 - 2.6e-39 135.4 0.1 1.9e-38 132.6 0.1 2.1 2 0 0 2 2 2 1 CPSF A subunit region Pkinase PF00069.25 EFE38780.1 - 1.8e-60 204.5 0.0 8.8e-60 202.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38780.1 - 7.3e-29 100.8 0.5 2.9e-20 72.6 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFE38780.1 - 0.00013 22.0 2.7 0.29 11.0 0.1 3.5 2 1 1 3 3 3 3 Phosphotransferase enzyme family Pkinase_C PF00433.24 EFE38780.1 - 0.00027 21.6 1.0 0.00078 20.1 1.0 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EFE38780.1 - 0.00062 19.2 1.0 0.0017 17.7 0.0 2.1 3 0 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 EFE38780.1 - 0.02 13.9 0.0 0.034 13.1 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EFE38780.1 - 0.024 14.0 0.1 0.081 12.3 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Abhydrolase_2 PF02230.16 EFE38781.1 - 2.3e-36 125.6 0.0 2.6e-36 125.5 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EFE38781.1 - 6.1e-08 32.4 0.0 6.9e-06 25.7 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 EFE38781.1 - 2.9e-06 27.0 0.0 3.7e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 EFE38781.1 - 2e-05 24.6 0.0 0.0094 15.8 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE38781.1 - 0.00064 19.1 0.3 0.0067 15.7 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 EFE38781.1 - 0.019 14.6 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 Putative esterase FSH1 PF03959.13 EFE38781.1 - 0.022 14.4 0.2 0.039 13.6 0.2 1.4 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Esterase_phd PF10503.9 EFE38781.1 - 0.11 11.9 0.0 0.77 9.2 0.0 1.9 2 0 0 2 2 2 0 Esterase PHB depolymerase Lipase_3 PF01764.25 EFE38781.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Ctr PF04145.15 EFE38784.1 - 4.2e-12 46.9 0.0 5.9e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family NAD_binding_6 PF08030.12 EFE38785.1 - 2.7e-19 69.8 0.0 4.1e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EFE38785.1 - 3.9e-19 69.0 11.4 1.1e-18 67.6 11.4 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EFE38785.1 - 5.9e-19 68.2 0.0 1.2e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 EFE38785.1 - 0.1 13.0 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain FAD_binding_3 PF01494.19 EFE38786.1 - 7.4e-67 226.1 0.2 6.8e-65 219.6 0.2 2.1 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EFE38786.1 - 1.3e-33 116.4 0.0 5.1e-33 114.4 0.0 1.9 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain Trp_halogenase PF04820.14 EFE38786.1 - 0.084 11.7 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Lactamase_B PF00753.27 EFE38786.1 - 0.085 12.8 0.1 1.9 8.4 0.1 2.3 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Pyr_redox_2 PF07992.14 EFE38786.1 - 0.13 11.5 0.1 1.5 8.0 0.0 2.5 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Nup35_RRM PF05172.13 EFE38787.1 - 0.0042 17.0 0.0 0.0077 16.2 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif PDZ_4 PF17816.1 EFE38788.1 - 0.043 14.2 0.1 0.057 13.8 0.1 1.2 1 0 0 1 1 1 0 PDZ domain Abhydrolase_3 PF07859.13 EFE38789.1 - 3.8e-24 85.7 0.0 1.5e-23 83.8 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFE38789.1 - 9.1e-22 77.4 0.0 1.1e-21 77.1 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase DUF2974 PF11187.8 EFE38789.1 - 0.075 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Coatomer_E PF04733.14 EFE38790.1 - 8.4e-64 215.8 8.9 9.7e-64 215.6 8.9 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EFE38790.1 - 2.7e-08 34.2 20.9 0.00052 20.5 3.4 4.4 2 1 1 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE38790.1 - 5.6e-08 32.9 5.2 0.011 15.9 1.2 3.4 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EFE38790.1 - 1.6e-06 28.6 21.1 0.0078 16.8 4.4 4.5 4 1 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFE38790.1 - 9.2e-06 26.1 17.6 0.021 15.6 0.0 4.9 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFE38790.1 - 0.00062 20.2 1.7 0.28 11.9 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFE38790.1 - 0.00068 19.9 14.2 0.09 13.1 2.6 4.4 3 2 1 4 4 4 2 Tetratricopeptide repeat Peptidase_S11 PF00768.20 EFE38790.1 - 0.012 15.1 0.2 0.017 14.6 0.2 1.3 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase DUF627 PF04781.12 EFE38790.1 - 0.034 14.2 0.9 0.079 13.0 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF627) TPR_1 PF00515.28 EFE38790.1 - 0.057 13.3 4.2 0.78 9.7 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFE38790.1 - 0.099 12.8 5.0 0.23 11.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFE38790.1 - 0.11 12.7 0.0 0.11 12.7 0.0 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat TetR_C_25 PF17933.1 EFE38790.1 - 0.13 12.6 0.5 0.32 11.3 0.5 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Type_III_YscG PF09477.10 EFE38790.1 - 0.24 11.4 6.8 1.2 9.2 2.8 3.1 1 1 1 3 3 3 0 Bacterial type II secretion system chaperone protein (type_III_yscG) TPR_4 PF07721.14 EFE38790.1 - 0.81 10.5 21.7 0.26 12.0 0.7 5.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFE38790.1 - 2.1 8.3 8.3 32 4.6 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Fungal_trans PF04082.18 EFE38791.1 - 7.3e-09 35.0 0.0 1.1e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain APH PF01636.23 EFE38794.1 - 2.2e-09 37.6 0.0 3.2e-08 33.8 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EFE38795.1 - 4.4e-14 52.5 0.0 1e-13 51.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38795.1 - 1.4e-09 37.6 0.0 2.2e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE38795.1 - 0.0011 18.9 0.2 0.21 11.5 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE38795.1 - 0.0048 16.5 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase AA_permease PF00324.21 EFE38797.1 - 1.8e-118 396.2 39.1 2.4e-118 395.8 39.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE38797.1 - 1e-28 100.3 43.6 1.6e-28 99.7 43.6 1.2 1 0 0 1 1 1 1 Amino acid permease F-box PF00646.33 EFE38798.1 - 6.9e-07 29.0 0.0 2.3e-06 27.3 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE38798.1 - 1.9e-05 24.5 0.3 4.3e-05 23.3 0.3 1.6 1 0 0 1 1 1 1 F-box-like FTA4 PF13093.6 EFE38800.1 - 2.6e-51 174.4 1.0 3.2e-28 99.0 0.0 2.1 1 1 1 2 2 2 2 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF1664 PF07889.12 EFE38800.1 - 0.03 14.4 0.2 0.43 10.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SlyX PF04102.12 EFE38801.1 - 0.022 15.4 0.9 0.14 12.8 0.3 2.4 2 0 0 2 2 2 0 SlyX SIKE PF05769.11 EFE38801.1 - 0.044 13.7 5.8 0.06 13.3 5.8 1.2 1 0 0 1 1 1 0 SIKE family RAP1 PF07218.11 EFE38801.1 - 7.3 4.7 7.5 9.8 4.3 7.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) HAD_2 PF13419.6 EFE38802.1 - 2.5e-06 27.7 0.0 3.9e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFE38802.1 - 0.015 15.6 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE38802.1 - 0.022 14.8 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 HAD-hyrolase-like Ribosomal_L5e PF17144.4 EFE38803.1 - 3e-80 268.0 0.2 4.3e-80 267.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EFE38803.1 - 8.5e-34 116.4 2.8 8.5e-34 116.4 2.8 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region LRR_6 PF13516.6 EFE38804.1 - 0.0015 18.4 2.7 2.4 8.4 0.0 5.2 6 0 0 6 6 6 1 Leucine Rich repeat DUF3135 PF11333.8 EFE38804.1 - 0.0028 17.9 0.2 0.18 12.1 0.1 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3135) ABC_membrane_2 PF06472.15 EFE38805.1 - 1.9e-103 345.6 1.0 2.7e-103 345.1 1.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFE38805.1 - 1.6e-18 67.5 0.0 2.9e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFE38805.1 - 5.8e-05 23.1 0.1 0.00017 21.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFE38805.1 - 0.0049 17.4 0.1 0.013 16.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFE38805.1 - 0.0093 15.7 0.0 0.041 13.6 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 EFE38805.1 - 0.035 13.5 0.0 0.1 12.0 0.0 1.7 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFE38805.1 - 0.059 13.7 0.2 0.42 11.0 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain Rad17 PF03215.15 EFE38805.1 - 0.11 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain RNA_helicase PF00910.22 EFE38805.1 - 0.15 12.4 0.0 0.34 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_15 PF13175.6 EFE38805.1 - 0.18 11.4 0.1 0.5 10.0 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain p450 PF00067.22 EFE38806.1 - 1.1e-66 225.4 0.0 1.5e-66 225.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 APH PF01636.23 EFE38809.1 - 6.6e-16 59.0 0.2 9.2e-16 58.5 0.2 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EFE38809.1 - 0.00045 19.7 0.1 0.057 12.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Choline_kinase PF01633.20 EFE38809.1 - 0.002 17.7 0.3 0.0031 17.1 0.3 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EFE38809.1 - 0.0088 15.7 0.1 0.063 12.9 0.0 2.0 2 0 0 2 2 2 1 RIO1 family DUF596 PF04591.12 EFE38809.1 - 0.078 13.1 0.3 0.18 12.0 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF596 Phosphorylase PF00343.20 EFE38810.1 - 0 1063.7 0.0 0 1063.5 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase TspO_MBR PF03073.15 EFE38812.1 - 0.013 15.5 0.4 0.015 15.3 0.4 1.1 1 0 0 1 1 1 0 TspO/MBR family G-alpha PF00503.20 EFE38813.1 - 8.8e-52 176.4 0.2 1.3e-51 175.9 0.2 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFE38813.1 - 6.2e-08 32.3 0.3 1.2e-07 31.3 0.3 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family RNA_pol PF00940.19 EFE38814.1 - 7.8e-184 611.3 0.0 1.2e-183 610.7 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EFE38814.1 - 7.1e-93 311.6 0.9 1.1e-92 311.1 0.9 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal HMMR_C PF15908.5 EFE38814.1 - 0.48 10.7 2.9 1.2 9.4 2.9 1.6 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal Sin_N PF04801.13 EFE38815.1 - 2.7e-28 99.4 0.6 9.9e-28 97.5 0.6 1.7 1 1 0 1 1 1 1 Sin-like protein conserved region DUF2615 PF11027.8 EFE38816.1 - 0.92 9.7 0.0 0.92 9.7 0.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) ATP-synt_S1 PF05827.12 EFE38817.1 - 4.8e-05 23.2 0.0 0.00011 22.1 0.0 1.5 2 0 0 2 2 2 1 Vacuolar ATP synthase subunit S1 (ATP6S1) PDGLE PF13190.6 EFE38817.1 - 0.12 12.2 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 PDGLE domain Nop25 PF09805.9 EFE38818.1 - 1.7e-38 132.2 10.2 1.7e-38 132.2 10.2 3.1 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) EIIBC-GUT_N PF03612.14 EFE38818.1 - 0.58 9.9 10.9 1.4 8.7 3.4 2.5 2 1 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Tropomyosin_1 PF12718.7 EFE38819.1 - 1.4e-49 168.0 34.7 1.7e-49 167.6 34.7 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 EFE38819.1 - 3.4e-09 36.4 35.7 9.6e-06 25.1 17.3 2.1 1 1 1 2 2 2 2 Tropomyosin Spc7 PF08317.11 EFE38819.1 - 0.00018 20.5 33.1 0.052 12.4 14.6 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein KLRAQ PF10205.9 EFE38819.1 - 0.00029 21.0 23.7 0.00032 20.9 9.5 3.2 1 1 2 3 3 3 1 Predicted coiled-coil domain-containing protein GAS PF13851.6 EFE38819.1 - 0.00075 18.9 33.4 0.0042 16.4 26.5 2.1 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EFE38819.1 - 0.0026 18.0 32.1 0.055 13.7 23.6 2.2 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 EFE38819.1 - 0.0034 17.4 6.1 0.0034 17.4 6.1 3.3 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 EFE38819.1 - 0.0039 17.2 17.7 0.011 15.7 4.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) DHR10 PF18595.1 EFE38819.1 - 0.021 14.9 16.9 0.021 14.9 16.9 2.6 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain ADIP PF11559.8 EFE38819.1 - 0.078 13.1 33.0 0.68 10.0 10.3 3.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Laminin_II PF06009.12 EFE38819.1 - 0.08 13.0 20.3 0.021 14.8 8.3 2.1 1 1 1 2 2 2 0 Laminin Domain II MAD PF05557.13 EFE38819.1 - 0.11 10.8 33.3 0.87 7.9 22.0 1.7 1 1 1 2 2 2 0 Mitotic checkpoint protein GAPES1 PF17155.4 EFE38819.1 - 0.21 10.9 1.2 0.27 10.5 1.2 1.2 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain DUF724 PF05266.14 EFE38819.1 - 0.33 10.7 26.5 0.31 10.9 10.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4200 PF13863.6 EFE38819.1 - 0.5 10.8 34.7 0.56 10.6 15.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ERM PF00769.19 EFE38819.1 - 0.69 9.7 39.8 0.32 10.8 19.7 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF3340 PF11818.8 EFE38819.1 - 0.69 10.1 24.3 1.8 8.7 24.3 1.6 1 1 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) SesA PF17107.5 EFE38819.1 - 0.87 9.8 10.9 0.48 10.6 7.6 2.1 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases BLOC1_2 PF10046.9 EFE38819.1 - 0.9 9.9 23.8 1.7 9.0 0.9 3.3 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Jnk-SapK_ap_N PF09744.9 EFE38819.1 - 1 9.6 34.8 0.21 11.8 24.3 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF3584 PF12128.8 EFE38819.1 - 1.1 6.6 28.2 1.4 6.4 28.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Atg14 PF10186.9 EFE38819.1 - 1.3 8.0 27.0 2.9 6.9 9.9 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 CLZ PF16526.5 EFE38819.1 - 1.4 9.3 23.5 0.42 11.0 2.6 3.1 1 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FlaC_arch PF05377.11 EFE38819.1 - 1.5 9.3 20.8 0.94 9.9 0.3 4.1 2 1 3 5 5 5 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 EFE38819.1 - 2.2 9.0 26.9 2.9 8.6 1.7 3.6 1 1 2 3 3 3 0 SlyX DUF3450 PF11932.8 EFE38819.1 - 3.5 6.9 31.1 0.23 10.7 9.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) KELK PF15796.5 EFE38819.1 - 3.5 8.1 31.9 28 5.2 15.2 3.5 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Cep57_MT_bd PF06657.13 EFE38819.1 - 3.7 8.1 21.2 0.13 12.7 4.6 3.6 1 1 3 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Med9 PF07544.13 EFE38819.1 - 5 7.3 27.6 0.43 10.7 5.0 3.3 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 AAA_13 PF13166.6 EFE38819.1 - 5.1 5.6 26.9 28 3.1 27.2 1.9 1 1 0 1 1 1 0 AAA domain PspB PF06667.12 EFE38819.1 - 6.7 6.8 17.6 0.91 9.6 4.5 3.6 1 1 2 3 3 3 0 Phage shock protein B JIP_LZII PF16471.5 EFE38819.1 - 6.8 6.9 26.2 0.5 10.6 5.6 3.7 2 1 1 4 4 4 0 JNK-interacting protein leucine zipper II PI3K_P85_iSH2 PF16454.5 EFE38819.1 - 7.4 6.1 29.1 8.6 5.9 23.2 2.3 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TMF_TATA_bd PF12325.8 EFE38819.1 - 7.6 6.8 32.7 34 4.7 11.1 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.6 EFE38819.1 - 8.2 5.7 24.4 9.4 5.5 16.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) BST2 PF16716.5 EFE38819.1 - 8.5 7.0 29.5 5.2 7.7 11.7 3.3 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 FapA PF03961.13 EFE38819.1 - 8.6 4.8 25.0 0.55 8.8 10.8 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A UPF0242 PF06785.11 EFE38819.1 - 8.7 6.4 33.1 13 5.8 12.2 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus KxDL PF10241.9 EFE38819.1 - 9.4 6.6 21.3 0.6 10.4 1.2 3.8 1 1 3 4 4 4 0 Uncharacterized conserved protein XRN_M PF17846.1 EFE38819.1 - 9.9 5.0 12.8 12 4.7 12.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF572 PF04502.13 EFE38820.1 - 7.3 6.1 19.1 8.8 5.8 14.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) CMAS PF02353.20 EFE38821.1 - 8.9e-59 199.0 0.0 1.1e-58 198.7 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EFE38821.1 - 1.4e-08 34.7 0.0 2.6e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38821.1 - 3.2e-08 34.1 0.0 7.4e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE38821.1 - 5e-08 33.5 0.0 1.3e-07 32.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38821.1 - 0.0025 18.5 0.0 0.0056 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EFE38821.1 - 0.014 15.0 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 FtsJ PF01728.19 EFE38821.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.14 EFE38821.1 - 0.15 11.6 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 EFE38821.1 - 0.21 11.3 0.0 0.34 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AMP-binding PF00501.28 EFE38822.1 - 5.1e-39 134.1 0.0 6e-39 133.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.28 EFE38823.1 - 1.4e-35 122.7 0.1 1.8e-35 122.3 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE38823.1 - 1e-16 61.7 0.0 1.6e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SBF PF01758.16 EFE38826.1 - 5.5e-30 104.5 12.3 4.3e-27 95.1 5.2 3.1 2 1 1 3 3 3 2 Sodium Bile acid symporter family ATP_bind_3 PF01171.20 EFE38827.1 - 8.1e-19 68.1 0.0 1.2e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 EFE38827.1 - 1.5e-18 66.0 5.4 1.5e-18 66.0 5.4 3.6 4 0 0 4 4 4 1 Zinc-ribbon tRNA_Me_trans PF03054.16 EFE38827.1 - 0.031 13.1 0.0 0.049 12.4 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase zf-UBR PF02207.20 EFE38827.1 - 0.6 10.3 6.6 2 8.6 0.7 2.5 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) RecR PF02132.15 EFE38827.1 - 1.8 8.2 10.2 0.054 13.1 1.6 2.7 3 0 0 3 3 3 0 RecR protein Acetyltransf_8 PF13523.6 EFE38828.1 - 6e-27 94.1 0.0 9.1e-27 93.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DHHC PF01529.20 EFE38831.1 - 1.3e-19 70.7 7.1 1.3e-19 70.7 7.1 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Glyco_hydro_17 PF00332.18 EFE38833.1 - 4.5e-08 33.1 2.9 5.8e-05 22.8 1.4 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 Rrn6 PF10214.9 EFE38836.1 - 0.035 12.6 3.5 0.032 12.7 3.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Pax2_C PF12403.8 EFE38836.1 - 0.069 13.2 1.6 0.11 12.6 1.6 1.3 1 0 0 1 1 1 0 Paired-box protein 2 C terminal Suf PF05843.14 EFE38836.1 - 0.84 9.6 6.1 1.1 9.2 6.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Orf78 PF06024.12 EFE38837.1 - 0.0025 18.1 1.8 1.7 8.9 1.4 3.2 2 1 0 2 2 2 2 Orf78 (ac78) TMCO5 PF14992.6 EFE38837.1 - 0.75 9.3 3.0 1.6 8.3 0.7 2.1 2 0 0 2 2 2 0 TMCO5 family HECT_2 PF09814.9 EFE38840.1 - 8.1e-23 80.9 0.0 8.8e-23 80.8 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Questin_oxidase PF14027.6 EFE38842.1 - 1e-87 294.9 0.7 1.2e-87 294.7 0.7 1.0 1 0 0 1 1 1 1 Questin oxidase-like TPR_10 PF13374.6 EFE38843.1 - 1.8e-46 154.8 20.6 6.5e-11 41.7 0.1 7.5 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFE38843.1 - 1.3e-44 150.4 14.8 3.4e-18 65.7 1.2 5.9 3 3 3 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFE38843.1 - 1.1e-12 47.1 17.3 0.0078 16.3 0.1 6.3 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFE38843.1 - 2.2e-09 36.7 20.8 0.0023 17.8 0.1 7.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFE38843.1 - 2.4e-09 36.6 15.6 4.8e-05 23.0 0.3 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFE38843.1 - 1.5e-07 31.1 15.9 0.45 10.9 0.0 6.9 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFE38843.1 - 1.7e-07 31.8 17.5 0.18 12.5 0.1 5.2 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EFE38843.1 - 3.3e-05 23.4 6.5 0.015 14.7 2.9 3.3 2 1 1 3 3 3 2 MalT-like TPR region TPR_4 PF07721.14 EFE38843.1 - 0.00018 21.8 3.1 1.1 10.0 0.0 5.2 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFE38843.1 - 0.0069 17.1 11.7 10 7.3 0.1 5.9 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE38843.1 - 0.011 15.4 5.9 16 5.3 0.1 4.6 4 0 0 4 4 4 0 TPR repeat ANAPC3 PF12895.7 EFE38843.1 - 0.023 14.9 5.8 0.051 13.8 0.9 3.6 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFE38843.1 - 0.042 14.2 10.6 1 9.9 0.3 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFE38843.1 - 0.08 13.5 14.9 7.2 7.2 0.0 4.7 3 1 1 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 EFE38843.1 - 0.97 9.5 4.0 0.67 10.0 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EFE38843.1 - 1 9.5 14.4 2.3 8.4 0.3 4.5 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 EFE38843.1 - 7.1 7.5 11.6 5.2 7.9 0.1 5.2 7 0 0 7 7 5 0 Tetratricopeptide repeat AAA PF00004.29 EFE38844.1 - 1.4e-49 167.9 0.0 4.4e-43 146.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE38844.1 - 8.7e-07 28.7 2.6 0.00062 19.5 0.0 3.2 3 0 0 3 3 3 2 AAA+ lid domain AAA_16 PF13191.6 EFE38844.1 - 2.6e-05 24.7 0.0 0.017 15.5 0.0 3.7 3 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EFE38844.1 - 0.0001 22.1 0.0 0.0003 20.6 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Parvo_NS1 PF01057.17 EFE38844.1 - 0.00041 19.5 0.0 0.00072 18.7 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 RNA_helicase PF00910.22 EFE38844.1 - 0.00051 20.4 0.1 0.012 16.0 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_2 PF07724.14 EFE38844.1 - 0.002 18.3 0.0 0.0061 16.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFE38844.1 - 0.002 18.4 0.0 0.032 14.5 0.0 3.0 3 1 1 4 4 3 1 AAA domain PhoH PF02562.16 EFE38844.1 - 0.0033 16.9 0.0 0.15 11.5 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein TIP49 PF06068.13 EFE38844.1 - 0.0045 16.2 0.0 0.009 15.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 EFE38844.1 - 0.0048 16.5 0.0 0.032 13.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFE38844.1 - 0.0051 17.0 0.0 0.33 11.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFE38844.1 - 0.0063 16.3 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EFE38844.1 - 0.015 15.9 0.0 0.087 13.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EFE38844.1 - 0.017 14.6 0.1 0.039 13.3 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFE38844.1 - 0.022 14.8 0.0 0.096 12.7 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 EFE38844.1 - 0.022 14.7 0.4 0.47 10.5 0.1 2.7 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain ATPase PF06745.13 EFE38844.1 - 0.023 14.0 0.0 0.062 12.6 0.0 1.7 1 0 0 1 1 1 0 KaiC TsaE PF02367.17 EFE38844.1 - 0.029 14.4 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFE38844.1 - 0.032 13.8 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Kinase-PolyVal PF18762.1 EFE38844.1 - 0.048 13.6 0.0 0.084 12.8 0.0 1.3 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins AAA_28 PF13521.6 EFE38844.1 - 0.1 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFE38844.1 - 0.16 11.6 0.1 0.73 9.5 0.1 2.0 2 0 0 2 2 2 0 AAA domain W2 PF02020.18 EFE38845.1 - 3.7e-18 65.4 2.1 3.7e-18 65.4 2.1 3.6 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 EFE38845.1 - 3.8e-11 42.2 13.1 1.5e-06 27.7 4.8 3.4 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFE38845.1 - 0.00075 19.2 8.3 0.0022 17.7 2.8 2.8 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EFE38845.1 - 0.004 15.4 0.3 0.0071 14.5 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) NTP_transferase PF00483.23 EFE38845.1 - 0.0089 15.6 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.12 EFE38845.1 - 0.086 11.8 0.2 0.2 10.6 0.2 1.5 1 1 0 1 1 1 0 L-fucokinase Cwf_Cwc_15 PF04889.12 EFE38845.1 - 3.2 7.4 10.6 6.4 6.4 10.6 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EFE38845.1 - 4.6 6.5 12.1 9.1 5.5 12.1 1.5 1 0 0 1 1 1 0 NOA36 protein IBR PF01485.21 EFE38846.1 - 8.6e-23 80.3 48.9 7.8e-13 48.4 5.7 4.4 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFE38846.1 - 0.00091 19.5 8.7 0.00091 19.5 8.7 4.1 3 1 1 4 4 4 2 Ring finger domain UN_NPL4 PF11543.8 EFE38846.1 - 0.0011 19.4 0.0 0.0019 18.6 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 zf-C3HC4 PF00097.25 EFE38846.1 - 0.0016 18.3 5.4 0.0016 18.3 5.4 4.6 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFE38846.1 - 0.0064 16.3 5.6 0.0064 16.3 5.6 5.0 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE38846.1 - 0.012 15.5 9.6 0.012 15.5 9.6 3.2 3 0 0 3 3 3 0 zinc-RING finger domain Mito_carr PF00153.27 EFE38847.1 - 3.3e-24 84.6 1.1 5.7e-22 77.5 0.1 2.0 1 1 1 2 2 2 2 Mitochondrial carrier protein tRNA-synt_1 PF00133.22 EFE38848.1 - 3.9e-34 117.9 0.0 2.3e-24 85.6 0.0 3.3 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EFE38848.1 - 4.5e-15 55.3 0.0 4.9e-10 38.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EFE38848.1 - 2.2e-11 43.9 0.0 5.9e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EFE38848.1 - 3.4e-07 29.9 0.0 7.5e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EFE38848.1 - 0.023 13.6 0.0 0.13 11.2 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (K) HD_3 PF13023.6 EFE38849.1 - 0.012 15.5 0.9 0.015 15.2 0.9 1.1 1 0 0 1 1 1 0 HD domain LAX PF15681.5 EFE38849.1 - 0.026 13.4 0.6 0.031 13.1 0.6 1.1 1 0 0 1 1 1 0 Lymphocyte activation family X LRS4 PF10422.9 EFE38849.1 - 0.1 12.1 3.1 0.12 11.9 3.1 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 L51_S25_CI-B8 PF05047.16 EFE38849.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.5 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF1751 PF08551.10 EFE38850.1 - 6e-29 100.5 0.5 1.3e-28 99.5 0.5 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EFE38850.1 - 0.00022 21.2 10.0 0.00022 21.2 10.0 1.8 2 0 0 2 2 2 1 Rhomboid family Spt5_N PF11942.8 EFE38850.1 - 1.1 10.3 6.6 1.2 10.1 1.9 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal ANAPC4_WD40 PF12894.7 EFE38851.1 - 3.3e-07 30.5 0.1 0.0019 18.4 0.0 4.8 3 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFE38851.1 - 1.9e-06 28.4 2.3 2.3 9.3 0.0 5.7 7 1 0 7 7 7 3 WD domain, G-beta repeat PD40 PF07676.12 EFE38851.1 - 0.92 9.5 3.2 1.2e+02 2.8 0.1 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat CALCOCO1 PF07888.11 EFE38852.1 - 0.0037 16.2 3.9 0.0049 15.8 3.9 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Phlebovirus_NSM PF07246.11 EFE38852.1 - 0.0089 15.4 0.6 0.013 14.9 0.6 1.2 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M DBR1 PF05011.13 EFE38852.1 - 0.029 14.8 0.4 0.044 14.2 0.4 1.3 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain DUF641 PF04859.12 EFE38852.1 - 0.044 14.1 1.5 0.088 13.1 1.5 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) WD40_alt PF14077.6 EFE38852.1 - 0.082 12.8 0.2 0.23 11.3 0.2 1.8 1 0 0 1 1 1 0 Alternative WD40 repeat motif DUF1664 PF07889.12 EFE38852.1 - 0.096 12.7 0.1 3.1 7.9 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) P35 PF02331.15 EFE38852.1 - 0.19 11.1 0.2 0.55 9.5 0.1 1.7 2 0 0 2 2 2 0 Apoptosis preventing protein JIP_LZII PF16471.5 EFE38852.1 - 0.56 10.4 4.8 9.1 6.5 0.5 2.6 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II Chorismate_bind PF00425.18 EFE38853.1 - 1.3e-91 306.8 0.0 1.8e-91 306.3 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EFE38853.1 - 1.7e-27 96.4 0.0 5.2e-24 85.1 0.0 3.7 3 1 1 4 4 4 2 Anthranilate synthase component I, N terminal region ENTH PF01417.20 EFE38854.1 - 3.5e-29 101.4 0.3 5.5e-29 100.8 0.3 1.3 1 0 0 1 1 1 1 ENTH domain DUF1720 PF08226.11 EFE38854.1 - 5.5e-09 36.3 40.0 5.5e-09 36.3 40.0 5.6 1 1 2 3 3 3 1 Domain of unknown function (DUF1720) UIM PF02809.20 EFE38854.1 - 0.013 15.4 8.4 0.17 11.9 2.3 2.7 2 0 0 2 2 2 0 Ubiquitin interaction motif Pkinase PF00069.25 EFE38855.1 - 8.6e-08 31.9 0.0 8.2e-07 28.6 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38855.1 - 0.00011 21.6 0.0 0.00042 19.7 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Cnd1 PF12717.7 EFE38857.1 - 1.7e-07 31.4 0.1 0.066 13.2 0.0 3.3 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFE38857.1 - 3.7e-06 26.7 1.1 1 9.8 0.0 5.3 6 0 0 6 6 6 2 HEAT repeat CLASP_N PF12348.8 EFE38857.1 - 6e-06 26.0 0.8 0.0023 17.5 0.0 2.6 3 0 0 3 3 2 2 CLASP N terminal HEAT_2 PF13646.6 EFE38857.1 - 2.8e-05 24.4 0.1 0.012 15.9 0.1 3.8 2 1 2 4 4 4 1 HEAT repeats Adaptin_N PF01602.20 EFE38857.1 - 6.5e-05 21.7 1.0 0.00069 18.3 1.0 2.8 1 1 0 1 1 1 1 Adaptin N terminal region Macoilin PF09726.9 EFE38857.1 - 0.0012 17.5 0.0 0.0023 16.6 0.0 1.4 1 0 0 1 1 1 1 Macoilin family TAN PF11640.8 EFE38857.1 - 0.0013 18.9 1.4 0.013 15.6 0.0 3.1 2 1 0 2 2 2 1 Telomere-length maintenance and DNA damage repair DCB PF16213.5 EFE38857.1 - 0.04 13.6 0.1 0.29 10.8 0.0 2.4 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 V-ATPase_H_C PF11698.8 EFE38857.1 - 0.049 13.7 0.1 1.8 8.7 0.1 3.0 3 0 0 3 3 3 0 V-ATPase subunit H HEAT_EZ PF13513.6 EFE38857.1 - 0.069 13.7 1.1 1.5 9.4 0.2 3.3 4 0 0 4 4 2 0 HEAT-like repeat Exonuc_VII_L PF02601.15 EFE38857.1 - 0.093 12.3 8.0 0.51 9.9 3.2 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit G-gamma PF00631.22 EFE38857.1 - 0.19 11.7 0.9 0.78 9.8 0.9 2.1 1 0 0 1 1 1 0 GGL domain Spc7 PF08317.11 EFE38857.1 - 0.73 8.7 14.7 0.2 10.5 11.4 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein Proteasom_PSMB PF10508.9 EFE38857.1 - 0.89 8.0 4.3 8.5 4.7 0.1 2.5 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit Atg14 PF10186.9 EFE38857.1 - 1.3 8.0 6.2 2.5 7.1 6.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 JIP_LZII PF16471.5 EFE38857.1 - 2 8.6 7.4 2.4 8.4 5.6 2.1 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II HsbA PF12296.8 EFE38857.1 - 2.6 8.5 4.5 23 5.4 0.1 3.3 3 1 0 3 3 2 0 Hydrophobic surface binding protein A MCC-bdg_PDZ PF10506.9 EFE38857.1 - 2.7 8.0 6.6 3.9 7.6 2.6 2.9 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Fez1 PF06818.15 EFE38857.1 - 3.3 8.1 15.8 0.41 11.1 10.2 2.1 2 0 0 2 2 2 0 Fez1 ERM PF00769.19 EFE38857.1 - 4.1 7.1 22.8 2.6 7.8 16.0 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF4407 PF14362.6 EFE38857.1 - 7.5 5.8 14.8 0.57 9.5 8.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Latarcin PF10279.9 EFE38857.1 - 8.5 6.9 7.8 6.7 7.2 4.5 2.5 3 0 0 3 3 3 0 Latarcin precursor Ribosomal_L7Ae PF01248.26 EFE38858.1 - 3.4e-21 74.8 0.3 5.8e-21 74.0 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RRP36 PF06102.12 EFE38858.1 - 0.011 15.8 0.5 0.011 15.8 0.5 2.1 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 RhoGAP PF00620.27 EFE38859.1 - 5.9e-40 136.6 0.0 1.4e-39 135.4 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EFE38859.1 - 2.1e-14 53.9 0.6 5.8e-14 52.5 0.0 2.2 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFE38859.1 - 0.0089 16.3 0.1 0.03 14.6 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain R_equi_Vir PF05526.11 EFE38859.1 - 0.016 15.1 0.8 0.066 13.1 0.8 2.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DivIC PF04977.15 EFE38859.1 - 2.5 7.9 5.8 28 4.6 5.5 2.9 2 0 0 2 2 2 0 Septum formation initiator DUF4763 PF15960.5 EFE38859.1 - 6.4 6.0 13.9 0.014 14.8 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Erv26 PF04148.13 EFE38860.1 - 1.1e-86 290.0 0.7 9.7e-86 286.8 0.7 1.9 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 Ferric_reduct PF01794.19 EFE38860.1 - 0.014 15.5 1.9 0.22 11.6 0.8 2.2 1 1 0 2 2 2 0 Ferric reductase like transmembrane component WBS_methylT PF12589.8 EFE38861.1 - 3.2e-15 56.6 3.9 5.6e-15 55.9 3.9 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EFE38861.1 - 2.2e-11 44.2 0.0 4.1e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38861.1 - 2.3e-10 41.1 0.0 7.7e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38861.1 - 3.7e-05 24.4 0.0 9.4e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38861.1 - 0.00015 21.6 0.0 0.00023 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFE38861.1 - 0.00058 19.7 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EFE38861.1 - 0.0023 17.3 0.0 0.02 14.2 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFE38861.1 - 0.0043 16.9 0.0 0.0068 16.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFE38861.1 - 0.037 13.3 0.0 0.46 9.7 0.0 2.0 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase ACT_7 PF13840.6 EFE38861.1 - 0.21 11.4 0.1 0.46 10.3 0.1 1.5 1 0 0 1 1 1 0 ACT domain Iso_dh PF00180.20 EFE38862.1 - 6.6e-84 282.0 0.0 8e-84 281.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Proteasome PF00227.26 EFE38865.1 - 3.6e-45 153.8 0.3 7.6e-32 110.3 0.0 2.6 3 0 0 3 3 3 2 Proteasome subunit Proteasome_A_N PF10584.9 EFE38865.1 - 0.027 14.1 0.2 0.027 14.1 0.2 1.7 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature NOA36 PF06524.12 EFE38865.1 - 1.2 8.4 11.0 1.5 8.1 11.0 1.2 1 0 0 1 1 1 0 NOA36 protein UPF0560 PF10577.9 EFE38865.1 - 2.7 6.4 4.5 3.3 6.1 4.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PBP1_TM PF14812.6 EFE38865.1 - 3.8 7.9 12.4 6.9 7.1 12.4 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 EFE38865.1 - 4.5 7.3 8.2 6 6.9 8.2 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 EFE38865.1 - 8.8 6.0 8.5 13 5.5 8.5 1.4 1 0 0 1 1 1 0 FAM176 family DMRL_synthase PF00885.19 EFE38866.1 - 3.8e-56 188.8 0.1 4.5e-56 188.6 0.1 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase SIS PF01380.22 EFE38867.1 - 2.6e-56 189.1 0.0 6.2e-31 107.0 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EFE38867.1 - 2.1e-17 63.6 0.0 3.9e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EFE38867.1 - 1e-10 41.6 0.0 2.2e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EFE38867.1 - 0.00033 19.7 0.0 0.00055 18.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II CCSMST1 PF15013.6 EFE38867.1 - 0.011 15.9 0.3 0.034 14.3 0.3 1.8 1 0 0 1 1 1 0 CCSMST1 family SIS_2 PF13580.6 EFE38867.1 - 0.076 13.0 0.0 3.1 7.8 0.0 2.5 2 0 0 2 2 2 0 SIS domain DUF4519 PF15012.6 EFE38867.1 - 0.27 11.4 4.1 0.36 11.0 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) CDC45 PF02724.14 EFE38868.1 - 0.037 12.3 3.9 0.047 12.0 3.9 1.1 1 0 0 1 1 1 0 CDC45-like protein COPI_C PF06957.11 EFE38868.1 - 0.082 11.7 1.6 0.13 11.0 1.6 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus DBINO PF13892.6 EFE38868.1 - 0.14 12.5 0.1 0.14 12.5 0.1 2.1 2 0 0 2 2 2 0 DNA-binding domain RRN3 PF05327.11 EFE38868.1 - 0.72 8.3 2.8 0.8 8.2 2.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pkinase PF00069.25 EFE38870.1 - 4.2e-67 226.3 0.2 4.2e-66 223.0 0.2 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38870.1 - 1.7e-50 171.7 0.0 3.3e-50 170.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EFE38870.1 - 5.3e-24 84.4 0.0 5.3e-24 84.4 0.0 2.5 3 0 0 3 3 3 1 P21-Rho-binding domain PH_11 PF15413.6 EFE38870.1 - 2e-15 57.1 0.1 5.2e-15 55.8 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Kinase-like PF14531.6 EFE38870.1 - 2.1e-05 24.0 0.0 3.8e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFE38870.1 - 2.4e-05 23.3 0.0 2.4e-05 23.3 0.0 2.3 2 1 0 2 2 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFE38870.1 - 4.4e-05 22.6 0.1 8.9e-05 21.6 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain PH PF00169.29 EFE38870.1 - 0.0002 21.8 0.1 0.0005 20.6 0.1 1.7 1 0 0 1 1 1 1 PH domain KIND PF16474.5 EFE38870.1 - 0.028 14.3 0.0 0.073 13.0 0.0 1.7 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain Seadorna_VP7 PF07387.11 EFE38870.1 - 0.038 13.0 0.1 0.065 12.3 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EFE38870.1 - 2.5 8.0 6.4 0.97 9.3 0.3 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family NAD_kinase PF01513.21 EFE38871.1 - 4.8e-48 163.9 0.0 8.6e-48 163.0 0.0 1.3 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EFE38871.1 - 0.013 15.1 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Acyltransferase PF01553.21 EFE38872.1 - 5.6e-28 97.2 0.0 9e-28 96.6 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EFE38872.1 - 3.3e-14 52.7 0.1 6.8e-14 51.7 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus TPR_2 PF07719.17 EFE38873.1 - 5.1e-25 85.5 22.7 0.0047 17.0 0.3 12.4 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 EFE38873.1 - 1.1e-22 78.9 19.9 0.0013 18.5 0.1 11.5 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_19 PF14559.6 EFE38873.1 - 1.1e-17 64.3 30.6 0.00021 21.7 0.0 9.8 10 2 2 12 12 12 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFE38873.1 - 2.3e-14 52.8 34.9 0.004 17.8 0.1 12.6 12 1 0 13 13 12 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFE38873.1 - 2.6e-14 52.2 23.6 0.085 13.1 0.1 11.8 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFE38873.1 - 1.3e-09 38.2 29.9 0.038 14.3 0.7 9.4 7 3 3 10 10 10 5 Tetratricopeptide repeat TPR_6 PF13174.6 EFE38873.1 - 1.2e-08 35.0 28.5 0.03 15.0 0.1 12.6 15 0 0 15 15 14 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFE38873.1 - 5.6e-08 33.3 27.9 0.16 12.6 0.1 8.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFE38873.1 - 4.5e-05 23.0 27.3 0.05 13.3 0.4 8.8 9 1 1 10 10 9 2 TPR repeat TPR_7 PF13176.6 EFE38873.1 - 0.00012 21.9 27.3 0.28 11.3 0.2 9.1 10 0 0 10 10 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFE38873.1 - 0.00043 20.5 23.7 0.14 12.6 0.1 9.7 12 0 0 12 12 10 1 Tetratricopeptide repeat TPR_4 PF07721.14 EFE38873.1 - 0.035 14.7 2.1 22 6.0 0.0 4.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFE38873.1 - 0.24 11.3 0.1 0.24 11.3 0.1 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat CCP_MauG PF03150.14 EFE38873.1 - 0.41 11.3 2.3 3 8.5 0.0 3.2 3 1 0 3 3 3 0 Di-haem cytochrome c peroxidase Fis1_TPR_C PF14853.6 EFE38873.1 - 2.5 8.2 7.8 5.3 7.2 0.1 4.3 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat SGL PF08450.12 EFE38874.1 - 1.9e-27 96.4 0.5 4.7e-14 52.6 0.0 2.3 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EFE38874.1 - 0.0043 17.1 0.1 0.084 13.0 0.0 2.9 3 1 0 3 3 3 1 Strictosidine synthase Arylesterase PF01731.20 EFE38874.1 - 0.12 12.6 0.0 0.61 10.3 0.0 2.1 2 0 0 2 2 2 0 Arylesterase SRP_TPR_like PF17004.5 EFE38878.1 - 3e-17 62.7 0.8 7.7e-17 61.4 0.2 2.0 3 0 0 3 3 3 1 Putative TPR-like repeat SRP72 PF08492.12 EFE38878.1 - 1.2e-13 51.3 6.2 1.2e-13 51.3 6.2 2.1 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 EFE38878.1 - 5.1e-06 26.9 5.9 0.022 15.3 0.0 5.0 4 2 2 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE38878.1 - 0.0011 19.1 4.8 3.8 7.8 0.1 5.7 4 2 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EFE38878.1 - 0.0027 18.0 1.3 2.9 8.3 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFE38878.1 - 0.0076 15.9 0.4 0.92 9.2 0.0 3.0 3 1 1 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_2 PF07719.17 EFE38878.1 - 0.081 13.1 9.1 6.7 7.1 1.7 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat AF0941-like PF14591.6 EFE38878.1 - 0.14 12.8 0.8 0.67 10.5 0.1 2.3 2 0 0 2 2 2 0 AF0941-like TPR_9 PF13371.6 EFE38878.1 - 0.25 11.5 4.4 0.58 10.3 0.0 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat VCX_VCY PF15231.6 EFE38878.1 - 0.53 11.0 6.8 1.1 9.9 6.8 1.5 1 0 0 1 1 1 0 Variable charge X/Y family TPR_1 PF00515.28 EFE38878.1 - 4.5 7.3 6.4 99 3.0 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Homeobox_KN PF05920.11 EFE38879.1 - 1.4e-10 40.9 1.4 1.7e-10 40.7 0.2 1.7 2 0 0 2 2 2 1 Homeobox KN domain HSP70 PF00012.20 EFE38882.1 - 6.3e-62 209.6 19.6 1.3e-61 208.5 2.9 3.1 3 1 0 3 3 3 2 Hsp70 protein MFS_1 PF07690.16 EFE38883.1 - 2.7e-23 82.5 60.4 1.2e-21 77.0 58.8 3.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE38883.1 - 2.2e-05 23.5 12.7 2.2e-05 23.5 12.7 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter tRNA-synt_1c PF00749.21 EFE38885.1 - 9.8e-98 326.9 0.0 1.4e-97 326.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFE38885.1 - 1.2e-29 103.5 0.0 3.3e-29 102.0 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain DUF3408 PF11888.8 EFE38885.1 - 5.6 7.1 8.0 13 5.9 8.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) ATPgrasp_N PF18130.1 EFE38887.1 - 6e-16 58.8 0.0 1.9e-15 57.1 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp N-terminal domain ATP-grasp_4 PF13535.6 EFE38887.1 - 1.9e-08 34.1 0.0 1.1e-07 31.6 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFE38887.1 - 7.6e-07 28.9 0.0 9.1e-06 25.3 0.0 2.1 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EFE38887.1 - 8e-05 22.7 0.0 0.0056 16.7 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain GDPD PF03009.17 EFE38889.1 - 3e-40 138.6 0.0 9.8e-40 136.9 0.0 1.7 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EFE38889.1 - 3.4e-23 82.0 0.2 2.3e-10 40.9 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE38889.1 - 2.5e-11 43.9 0.5 0.021 15.4 0.0 5.6 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE38889.1 - 3.8e-08 32.9 0.1 0.31 11.7 0.0 5.5 6 0 0 6 6 6 2 Ankyrin repeat Ank PF00023.30 EFE38889.1 - 3.3e-07 30.5 0.0 0.0069 16.8 0.0 4.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFE38889.1 - 3.7e-07 30.3 0.1 0.0062 16.8 0.0 4.5 2 1 3 5 5 5 2 Ankyrin repeats (many copies) SPX PF03105.19 EFE38889.1 - 0.0006 19.8 0.2 0.0006 19.8 0.2 2.2 3 0 0 3 3 3 1 SPX domain PEGA PF08308.11 EFE38889.1 - 0.15 11.9 0.1 2.6 8.0 0.0 2.4 2 0 0 2 2 2 0 PEGA domain Ank_2 PF12796.7 EFE38890.1 - 2.9e-23 82.3 0.0 9.1e-10 39.0 0.0 4.9 2 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE38890.1 - 5.5e-20 71.5 0.9 0.00018 22.0 0.0 5.9 3 3 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE38890.1 - 1.7e-17 61.7 1.6 0.087 13.4 0.0 7.6 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EFE38890.1 - 2.5e-17 62.4 4.0 0.00025 21.4 0.0 6.9 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EFE38890.1 - 1.1e-13 51.1 2.3 1.1e-05 25.5 0.0 4.9 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Helo_like_N PF17111.5 EFE38890.1 - 0.00019 20.9 1.8 0.00058 19.3 1.8 1.9 1 1 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Fungal_trans PF04082.18 EFE38892.1 - 4.6e-19 68.5 0.0 1.7e-17 63.3 0.0 2.5 2 0 0 2 2 2 2 Fungal specific transcription factor domain DUF951 PF06107.11 EFE38893.1 - 0.14 12.1 0.7 0.31 11.0 0.7 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) But2 PF09792.9 EFE38894.1 - 0.012 16.0 0.0 0.079 13.3 0.0 2.0 1 1 0 1 1 1 0 Ubiquitin 3 binding protein But2 C-terminal domain MFS_1 PF07690.16 EFE38895.1 - 3.4e-42 144.7 31.7 3.4e-42 144.7 31.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE38895.1 - 2e-13 50.1 4.5 2e-13 50.1 4.5 1.8 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFE38895.1 - 5.3e-06 25.1 1.0 5.3e-06 25.1 1.0 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EFE38895.1 - 4.4e-05 23.0 1.8 4.4e-05 23.0 1.8 2.9 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB Vps55 PF04133.14 EFE38895.1 - 0.016 15.2 0.6 0.016 15.2 0.6 3.0 3 0 0 3 3 3 0 Vacuolar protein sorting 55 DUF697 PF05128.12 EFE38895.1 - 1.8 8.2 4.6 8 6.1 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF697) Alpha-amylase PF00128.24 EFE38896.1 - 1.6e-19 70.7 3.1 1.3e-18 67.7 3.1 2.0 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DEAD PF00270.29 EFE38897.1 - 2.4e-24 86.1 0.5 9.9e-24 84.1 0.5 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE38897.1 - 7.4e-23 81.0 0.0 2.2e-22 79.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE38897.1 - 7e-05 22.9 0.0 0.00016 21.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EFE38897.1 - 0.12 11.2 0.0 1.4 7.6 0.0 2.0 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Ribonuc_L-PSP PF01042.21 EFE38898.1 - 1.7e-29 102.2 0.0 4.6e-29 100.9 0.0 1.6 1 1 0 1 1 1 1 Endoribonuclease L-PSP GGACT PF06094.12 EFE38898.1 - 0.015 15.9 0.0 0.34 11.5 0.0 2.0 1 1 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like HLH PF00010.26 EFE38901.1 - 2e-08 34.0 0.0 4.9e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hamartin PF04388.12 EFE38901.1 - 0.0078 14.9 1.5 0.0091 14.7 1.5 1.1 1 0 0 1 1 1 1 Hamartin protein HNH_2 PF13391.6 EFE38902.1 - 9.3e-16 57.7 0.0 1.9e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease Maf PF02545.14 EFE38903.1 - 4.8e-45 153.4 0.0 5.8e-45 153.1 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein CybS PF05328.12 EFE38904.1 - 7.8e-46 155.1 0.0 1.1e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit ADH_zinc_N PF00107.26 EFE38905.1 - 7.4e-22 77.7 0.0 1e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EFE38905.1 - 2.1e-18 66.2 0.0 4.2e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EFE38905.1 - 7.1e-12 46.5 0.0 1.2e-11 45.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 EFE38905.1 - 0.22 11.2 0.0 1.5 8.5 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2855) Peptidase_M16 PF00675.20 EFE38906.1 - 8.7e-55 184.8 0.0 3.1e-54 183.0 0.1 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFE38906.1 - 6.1e-40 137.2 0.0 1.3e-38 132.8 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain MFS_1 PF07690.16 EFE38907.1 - 1.9e-28 99.4 56.5 1.5e-26 93.2 43.5 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Nitroreductase PF00881.24 EFE38908.1 - 5.6e-16 59.1 0.0 6.9e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Phosphoesterase PF04185.14 EFE38908.1 - 0.062 12.5 0.1 0.14 11.3 0.0 1.5 1 1 0 2 2 2 0 Phosphoesterase family Epimerase PF01370.21 EFE38909.1 - 8.2e-20 71.3 0.0 1e-19 70.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFE38909.1 - 1.5e-12 47.6 0.0 4.9e-12 45.9 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFE38909.1 - 7.3e-10 38.3 0.0 9.2e-10 38.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFE38909.1 - 0.00027 20.2 0.2 0.46 9.6 0.2 2.3 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EFE38909.1 - 0.0006 19.0 0.0 0.0011 18.1 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFE38909.1 - 0.0011 18.8 0.0 0.0022 17.9 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EFE38909.1 - 0.0046 16.4 0.0 0.017 14.6 0.0 1.9 3 0 0 3 3 3 1 short chain dehydrogenase KR PF08659.10 EFE38909.1 - 0.005 16.8 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.23 EFE38909.1 - 0.14 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Fibrillarin PF01269.17 EFE38910.1 - 1.6e-103 344.7 0.0 2e-103 344.4 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EFE38910.1 - 4.7e-06 26.4 0.0 7.7e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 EFE38910.1 - 0.014 15.0 0.0 0.03 14.0 0.0 1.5 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 EFE38910.1 - 0.028 14.2 0.1 0.044 13.5 0.1 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF3455 PF11937.8 EFE38911.1 - 7.2e-43 146.7 0.0 8.9e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) DUF2990 PF11693.8 EFE38911.1 - 0.00035 20.7 0.0 0.00069 19.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2990) CASP_C PF08172.12 EFE38912.1 - 8.5e-90 300.5 0.3 8.5e-90 300.5 0.3 3.4 3 1 0 3 3 3 1 CASP C terminal HTH_Crp_2 PF13545.6 EFE38912.1 - 0.048 13.6 1.1 0.16 12.0 1.1 1.9 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain DUF5320 PF17253.2 EFE38912.1 - 3.3 8.8 5.8 9 7.4 0.4 3.6 3 1 0 3 3 3 0 Family of unknown function (DUF5320) Vps39_2 PF10367.9 EFE38913.1 - 4.7e-08 33.5 0.2 1.6e-07 31.8 0.0 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EFE38913.1 - 0.11 12.1 0.0 18 4.8 0.0 2.4 2 0 0 2 2 2 0 CNH domain PALP PF00291.25 EFE38914.1 - 2.4e-58 197.9 0.3 4.2e-58 197.1 0.3 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M20 PF01546.28 EFE38914.1 - 2.6e-23 82.8 0.2 9.2e-23 81.0 0.1 1.9 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFE38914.1 - 4.6e-19 68.3 0.0 1.3e-18 66.9 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFE38914.1 - 5.1e-05 23.0 0.1 0.00011 21.9 0.1 1.6 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 EFE38914.1 - 0.0064 15.5 0.0 8.8 5.2 0.0 3.1 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase UBA_4 PF14555.6 EFE38915.1 - 2.2e-11 43.4 0.0 4.1e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EFE38915.1 - 1.7e-08 34.5 0.0 4.1e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 UBX domain AAR2 PF05282.11 EFE38915.1 - 0.069 12.5 5.7 0.11 11.9 5.7 1.2 1 0 0 1 1 1 0 AAR2 protein RR_TM4-6 PF06459.12 EFE38915.1 - 0.11 12.3 5.4 0.22 11.3 5.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CTP_transf_like PF01467.26 EFE38915.1 - 0.21 11.8 0.5 0.48 10.6 0.5 1.6 1 0 0 1 1 1 0 Cytidylyltransferase-like DUF1682 PF07946.14 EFE38915.1 - 0.3 10.2 10.6 0.48 9.6 10.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Atg14 PF10186.9 EFE38915.1 - 0.62 9.1 7.6 0.92 8.5 7.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ALMT PF11744.8 EFE38915.1 - 8.5 5.1 5.3 13 4.5 5.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 EFE38915.1 - 8.5 5.0 8.8 13 4.4 8.8 1.2 1 0 0 1 1 1 0 Presenilin Pan3_PK PF18101.1 EFE38916.1 - 3.5e-62 208.4 0.4 5.2e-62 207.9 0.4 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Zn_clus PF00172.18 EFE38918.1 - 0.64 10.2 11.9 1.8 8.8 11.9 1.7 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain FKBP_N PF01346.18 EFE38918.1 - 1.4 10.0 9.0 1.1 10.2 4.3 2.5 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Dioxygenase_N PF04444.14 EFE38919.1 - 2.6e-30 104.1 0.0 4.5e-30 103.3 0.0 1.4 1 0 0 1 1 1 1 Catechol dioxygenase N terminus Dioxygenase_C PF00775.21 EFE38919.1 - 3.1e-19 69.1 0.0 5.8e-19 68.2 0.0 1.5 1 1 0 1 1 1 1 Dioxygenase CarboxypepD_reg PF13620.6 EFE38919.1 - 0.0053 17.0 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Ribosomal_L22 PF00237.19 EFE38920.1 - 4.4e-40 136.1 0.1 6.6e-40 135.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e 2-Hacid_dh_C PF02826.19 EFE38921.1 - 1.1e-56 191.0 0.0 1.4e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFE38921.1 - 3.3e-18 65.6 0.0 4.1e-18 65.3 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFE38921.1 - 0.0021 18.3 0.1 0.0049 17.1 0.1 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EFE38921.1 - 0.016 15.3 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ADH_zinc_N PF00107.26 EFE38923.1 - 5.9e-13 48.9 0.0 9.6e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFE38923.1 - 5.9e-09 35.7 0.1 0.0045 16.5 0.0 2.6 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 EFE38923.1 - 0.03 13.9 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 EFE38923.1 - 0.032 14.5 0.0 0.088 13.1 0.0 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 EFE38923.1 - 0.056 13.1 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 EFE38923.1 - 0.087 12.0 0.6 0.8 8.9 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Ldh_1_N PF00056.23 EFE38923.1 - 0.14 12.3 1.2 0.16 12.0 0.1 1.6 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain ITAM_Cys-rich PF10538.9 EFE38923.1 - 0.16 11.8 0.1 0.29 10.9 0.1 1.4 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif adh_short_C2 PF13561.6 EFE38924.1 - 2.5e-36 125.4 0.1 3e-36 125.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE38924.1 - 4.2e-35 121.0 0.3 6.6e-35 120.3 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE38924.1 - 0.00022 21.2 0.0 0.00034 20.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EFE38924.1 - 0.0015 18.4 0.0 0.0032 17.4 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 EFE38924.1 - 0.053 12.9 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) PRA1 PF03208.19 EFE38925.1 - 0.17 11.5 3.8 0.21 11.2 3.8 1.1 1 0 0 1 1 1 0 PRA1 family protein Fungal_trans PF04082.18 EFE38926.1 - 4.5e-09 35.7 0.0 1.4e-07 30.8 0.0 2.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE38926.1 - 0.011 15.9 4.0 0.02 15.0 4.0 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_A21 PF03566.13 EFE38927.1 - 7.3 4.7 5.8 7.4 4.7 5.8 1.0 1 0 0 1 1 1 0 Peptidase family A21 Polysacc_deac_1 PF01522.21 EFE38928.1 - 1.1e-27 96.4 0.0 1.7e-27 95.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 EFE38928.1 - 0.018 14.3 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Peptidase_M35 PF02102.15 EFE38929.1 - 1.7e-105 352.8 5.6 2e-105 352.7 5.6 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EFE38929.1 - 1.1e-42 146.1 0.8 1.9e-42 145.3 0.8 1.4 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 EFE38929.1 - 0.00086 18.9 0.3 0.0039 16.8 0.3 1.9 1 1 0 1 1 1 1 Putative peptidase family Semialdhyde_dhC PF02774.18 EFE38930.1 - 3.3e-37 128.3 0.0 4.3e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EFE38930.1 - 6.1e-14 52.5 0.0 3e-13 50.3 0.0 2.0 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain TMEM135_C_rich PF15982.5 EFE38931.1 - 6e-05 23.7 1.1 0.00016 22.2 1.1 1.8 1 1 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 Cation_ATPase_C PF00689.21 EFE38931.1 - 0.024 14.4 0.1 0.043 13.5 0.1 1.4 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus HLH PF00010.26 EFE38932.1 - 2.1e-06 27.6 0.1 5.7e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain BTRD1 PF17660.1 EFE38933.1 - 2.7e-75 248.0 12.9 3e-16 59.0 0.3 5.0 5 0 0 5 5 5 5 Bacterial tandem repeat domain 1 Ser_hydrolase PF06821.13 EFE38933.1 - 0.011 15.6 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase UvrA_inter PF17760.1 EFE38933.1 - 0.11 12.5 0.2 1.7 8.7 0.0 2.8 3 0 0 3 3 3 0 UvrA interaction domain AvrRpt-cleavage PF05627.11 EFE38933.1 - 0.16 11.4 4.4 1.2 8.5 0.1 4.1 5 0 0 5 5 5 0 Cleavage site for pathogenic type III effector avirulence factor Avr APH PF01636.23 EFE38934.1 - 4e-19 69.5 0.0 3.6e-18 66.4 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE38934.1 - 0.00015 20.7 0.0 0.01 14.8 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) EcKinase PF02958.20 EFE38934.1 - 0.00017 21.0 0.0 0.00028 20.3 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase CENP-Q PF13094.6 EFE38935.1 - 4.8e-35 121.2 9.6 8.2e-35 120.5 9.6 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit ZapB PF06005.12 EFE38935.1 - 0.0072 16.7 16.3 0.013 15.9 12.5 2.6 2 0 0 2 2 2 1 Cell division protein ZapB BRE1 PF08647.11 EFE38935.1 - 0.0074 16.3 10.2 0.026 14.6 10.2 1.9 1 0 0 1 1 1 1 BRE1 E3 ubiquitin ligase Flagellar_put PF12611.8 EFE38935.1 - 0.16 11.8 0.0 0.36 10.6 0.0 1.7 1 0 0 1 1 1 0 Putative flagellar DUF4407 PF14362.6 EFE38935.1 - 0.52 9.6 7.4 0.82 9.0 7.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4337 PF14235.6 EFE38935.1 - 0.57 10.3 3.9 1.4 9.0 3.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Leu_zip PF15294.6 EFE38935.1 - 1.1 8.8 14.0 0.14 11.7 10.1 1.5 2 0 0 2 2 2 0 Leucine zipper Spc24 PF08286.11 EFE38935.1 - 2.2 8.6 7.5 5 7.4 5.5 2.4 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Cep57_CLD_2 PF14197.6 EFE38935.1 - 4.9 7.3 18.0 9.6 6.4 0.1 3.4 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 EVC2_like PF12297.8 EFE38936.1 - 0.86 8.2 2.6 1.2 7.8 2.6 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Med3 PF11593.8 EFE38936.1 - 2 7.5 12.3 2.6 7.1 12.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal WD40 PF00400.32 EFE38939.1 - 2.2e-15 56.7 8.3 0.00069 20.4 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat FTA2 PF13095.6 EFE38940.1 - 3.5e-41 141.2 0.1 5.7e-29 101.3 0.0 2.6 2 1 1 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EFE38940.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family CENP-B_dimeris PF09026.10 EFE38941.1 - 2.2 8.7 8.7 4.2 7.8 8.7 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sugar_tr PF00083.24 EFE38942.1 - 1.6e-78 264.6 20.7 2e-78 264.3 20.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE38942.1 - 3.6e-25 88.7 20.8 1.8e-23 83.1 19.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4181 PF13789.6 EFE38942.1 - 0.45 10.8 4.4 0.33 11.2 0.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4181) GCN5L1 PF06320.13 EFE38943.1 - 3.7e-17 62.5 2.0 3.7e-17 62.5 2.0 1.3 2 0 0 2 2 2 1 GCN5-like protein 1 (GCN5L1) DUF3552 PF12072.8 EFE38943.1 - 0.015 14.7 3.3 0.017 14.6 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DASH_Dad2 PF08654.10 EFE38943.1 - 0.049 14.0 1.1 0.26 11.8 0.7 2.1 1 1 1 2 2 2 0 DASH complex subunit Dad2 DUF2570 PF10828.8 EFE38943.1 - 0.068 13.0 0.6 0.1 12.4 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) DUF630 PF04783.12 EFE38943.1 - 0.1 12.8 0.1 0.26 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF630) DivIC PF04977.15 EFE38943.1 - 0.28 11.0 2.6 0.51 10.1 2.6 1.4 1 0 0 1 1 1 0 Septum formation initiator APG6_N PF17675.1 EFE38943.1 - 1.4 9.5 8.8 2.2 8.8 8.8 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region Syntaxin-6_N PF09177.11 EFE38943.1 - 2.6 8.7 6.7 1.5e+02 3.0 6.7 2.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DNA_mis_repair PF01119.19 EFE38944.1 - 9.1e-21 73.7 0.0 3.5e-19 68.6 0.0 2.6 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 EFE38944.1 - 3.9e-19 68.9 2.3 7.5e-16 58.2 1.9 3.1 2 1 0 2 2 2 2 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 EFE38944.1 - 1.5e-12 47.5 0.1 5.5e-12 45.7 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFE38944.1 - 1.4e-06 28.8 0.0 9.4e-06 26.1 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Serinc PF03348.15 EFE38945.1 - 1.2e-153 512.1 9.7 1.3e-153 512.0 9.7 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) YqhR PF11085.8 EFE38945.1 - 0.32 10.9 13.0 0.057 13.3 6.5 2.6 2 0 0 2 2 2 0 Conserved membrane protein YqhR DUF4148 PF13663.6 EFE38945.1 - 1.3 9.2 7.7 0.13 12.5 1.7 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) Nodulin-like PF06813.13 EFE38946.1 - 4.3e-16 59.2 10.4 1.8e-13 50.6 10.4 2.2 1 1 0 1 1 1 1 Nodulin-like MFS_1 PF07690.16 EFE38946.1 - 4.3e-07 29.2 17.4 0.00029 19.9 13.0 2.6 3 0 0 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFE38946.1 - 3.4 6.1 15.6 5.6 5.4 15.6 1.3 1 0 0 1 1 1 0 MFS/sugar transport protein DUF3464 PF11947.8 EFE38947.1 - 0.026 14.3 0.3 0.043 13.6 0.3 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 MFS_1 PF07690.16 EFE38947.1 - 0.18 10.7 11.3 0.071 12.0 5.0 2.1 1 1 1 2 2 2 0 Major Facilitator Superfamily BTP PF05232.12 EFE38947.1 - 1.3 9.1 5.6 0.52 10.4 2.6 1.9 2 1 0 2 2 2 0 Chlorhexidine efflux transporter Pkinase PF00069.25 EFE38948.1 - 6.2e-11 42.2 0.0 1.9e-09 37.3 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE38948.1 - 1.7e-09 37.3 0.0 2e-08 33.8 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Mob1_phocein PF03637.17 EFE38949.1 - 3.3e-23 82.6 0.3 1.2e-22 80.8 0.0 1.8 2 0 0 2 2 2 1 Mob1/phocein family CxC6 PF18721.1 EFE38949.1 - 0.62 10.4 5.1 1.2 9.4 5.1 1.4 1 0 0 1 1 1 0 CxC6 like cysteine cluster associated with KDZ transposases cobW PF02492.19 EFE38950.1 - 3.5e-29 101.6 0.1 5.1e-29 101.1 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFE38950.1 - 3.7e-07 30.0 0.0 7.1e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain CDCA PF18484.1 EFE38950.1 - 0.019 14.8 0.1 0.063 13.1 0.0 1.8 2 0 0 2 2 2 0 Cadmium carbonic anhydrase repeat Auxin_BP PF02041.16 EFE38950.1 - 0.088 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Auxin binding protein HAUS6_N PF14661.6 EFE38951.1 - 1.9e-42 145.4 0.7 2.7e-42 144.9 0.0 1.6 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus HD_3 PF13023.6 EFE38952.1 - 3.6e-49 166.9 0.1 4.3e-49 166.6 0.1 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EFE38952.1 - 3.9e-13 49.6 0.1 5.4e-13 49.1 0.1 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EFE38952.1 - 0.0053 17.0 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 HD domain HATPase_c_4 PF13749.6 EFE38952.1 - 0.14 12.3 0.0 0.34 11.1 0.0 1.7 1 0 0 1 1 1 0 Putative ATP-dependent DNA helicase recG C-terminal Rad4 PF03835.15 EFE38953.1 - 1.2e-31 109.4 1.5 1.7e-31 108.9 0.1 2.1 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EFE38953.1 - 9.2e-29 99.7 0.2 1.9e-28 98.7 0.2 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 EFE38953.1 - 1.4e-16 61.1 1.7 3.3e-16 60.0 0.1 2.5 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 BHD_1 PF10403.9 EFE38953.1 - 2.5e-14 52.9 0.3 6.7e-14 51.5 0.1 1.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 EFE38953.1 - 0.00052 20.4 0.0 0.0031 17.9 0.0 2.3 2 0 0 2 2 2 1 Transglutaminase-like superfamily DNA_pol_phi PF04931.13 EFE38953.1 - 8.6 4.3 8.6 14 3.7 8.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi HIT PF01230.23 EFE38954.1 - 6.4e-23 81.3 0.0 1.3e-22 80.3 0.0 1.5 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EFE38954.1 - 1e-05 26.0 0.0 2.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EFE38954.1 - 0.0095 15.8 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 GalP_UDP_tr_C PF02744.17 EFE38954.1 - 0.083 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain Methyltransf_11 PF08241.12 EFE38955.1 - 1.5e-23 83.3 0.0 2.5e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38955.1 - 6.3e-22 78.1 0.0 1.3e-21 77.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38955.1 - 1.4e-14 54.2 0.0 1.8e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE38955.1 - 1.3e-12 48.3 0.0 5.4e-12 46.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE38955.1 - 2.2e-10 40.6 0.0 3.3e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE38955.1 - 4.8e-09 35.9 0.0 3.6e-08 33.0 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFE38955.1 - 1.4e-05 24.8 0.0 2.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EFE38955.1 - 0.00025 21.0 0.0 0.00037 20.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFE38955.1 - 0.00038 19.9 0.0 0.00056 19.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DREV PF05219.12 EFE38955.1 - 0.0026 16.9 0.0 0.0039 16.3 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase CMAS PF02353.20 EFE38955.1 - 0.0027 17.0 0.0 0.0041 16.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MetW PF07021.12 EFE38955.1 - 0.0031 17.1 0.0 0.0048 16.5 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 EFE38955.1 - 0.0078 16.2 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EFE38955.1 - 0.015 14.2 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) TehB PF03848.14 EFE38955.1 - 0.029 13.8 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_24 PF13578.6 EFE38955.1 - 0.048 14.7 0.0 0.13 13.2 0.0 1.7 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 EFE38955.1 - 0.055 13.3 0.0 0.14 12.0 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase DUF938 PF06080.12 EFE38955.1 - 0.21 11.3 0.0 1.3 8.8 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF938) CoA_binding_2 PF13380.6 EFE38956.1 - 0.089 13.3 0.0 0.095 13.2 0.0 1.2 1 0 0 1 1 1 0 CoA binding domain CoA_binding_2 PF13380.6 EFE38957.1 - 1.2e-10 41.8 0.0 2e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 CoA binding domain Dcc1 PF09724.9 EFE38959.1 - 4.2e-28 98.6 0.2 8.1e-26 91.1 0.2 2.0 1 1 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Anp1 PF03452.14 EFE38960.1 - 6.8e-108 360.1 0.0 6.8e-108 360.1 0.0 2.7 4 0 0 4 4 4 1 Anp1 tRNA_bind PF01588.20 EFE38961.1 - 2.4e-20 72.5 0.0 1.2e-19 70.2 0.0 2.1 1 1 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 EFE38961.1 - 0.0055 16.7 0.0 0.0097 15.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Asp PF00026.23 EFE38962.1 - 2.1e-59 201.5 0.0 2.4e-59 201.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFE38962.1 - 2.1e-08 34.6 0.2 0.0073 16.6 0.1 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFE38962.1 - 1.8e-06 28.5 0.6 0.0079 16.8 0.2 2.7 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EFE38962.1 - 4.1e-05 24.0 0.1 0.019 15.5 0.0 2.9 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease ParA PF10609.9 EFE38963.1 - 7.5e-95 317.0 0.0 8.8e-95 316.8 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFE38963.1 - 5.6e-08 32.9 0.0 1.8e-07 31.3 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFE38963.1 - 6.7e-06 26.1 0.0 2.2e-05 24.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EFE38963.1 - 7.9e-06 25.3 1.1 0.00019 20.7 0.2 2.5 1 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 EFE38963.1 - 0.0041 16.4 0.0 0.0085 15.4 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.6 EFE38963.1 - 0.0052 16.6 0.0 1.3 8.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain CLP1_P PF16575.5 EFE38963.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RsgA_GTPase PF03193.16 EFE38963.1 - 0.021 14.7 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 EFE38963.1 - 0.026 14.1 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFE38963.1 - 0.044 13.5 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EFE38963.1 - 0.1 12.2 0.0 0.22 11.1 0.0 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 EFE38963.1 - 0.14 12.5 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EFE38963.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 EFE38963.1 - 0.24 11.3 0.0 0.41 10.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain PEMT PF04191.13 EFE38964.1 - 7.2e-61 203.2 8.4 7.6e-37 126.0 0.4 3.3 3 0 0 3 3 3 2 Phospholipid methyltransferase SKICH PF17751.1 EFE38964.1 - 0.036 14.6 0.1 1.2 9.7 0.0 2.4 2 0 0 2 2 2 0 SKICH domain HECW_N PF16562.5 EFE38964.1 - 0.047 13.5 0.1 0.15 11.9 0.1 1.8 2 0 0 2 2 2 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 FGGY_C PF02782.16 EFE38965.1 - 4.4e-50 170.2 0.2 7.4e-50 169.4 0.2 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EFE38965.1 - 1.5e-22 80.4 0.0 1.7e-21 77.0 0.0 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EFE38965.1 - 0.076 12.5 0.1 0.18 11.3 0.0 1.7 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family F-box-like_2 PF13013.6 EFE38967.1 - 0.0028 17.6 0.2 0.0068 16.4 0.2 1.6 1 0 0 1 1 1 1 F-box-like domain F-box PF00646.33 EFE38967.1 - 0.0028 17.5 2.4 0.0057 16.5 2.4 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE38967.1 - 0.32 10.9 2.3 0.82 9.6 2.3 1.8 1 0 0 1 1 1 0 F-box-like PPP4R2 PF09184.11 EFE38967.1 - 0.6 9.6 7.5 1 8.9 7.5 1.3 1 0 0 1 1 1 0 PPP4R2 TFB6 PF17110.5 EFE38967.1 - 1.3 8.7 4.8 2.2 8.0 4.8 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RNA_pol_3_Rpc31 PF11705.8 EFE38967.1 - 1.7 8.9 17.7 14 5.8 15.2 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 F-box_4 PF15966.5 EFE38967.1 - 1.8 8.4 3.4 1 9.2 1.0 1.8 2 0 0 2 2 2 0 F-box Y_phosphatase PF00102.27 EFE38968.1 - 1e-64 218.3 0.1 1.5e-64 217.8 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 EFE38968.1 - 5.4e-10 39.8 0.0 2e-09 37.9 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 EFE38968.1 - 0.019 14.8 0.4 0.042 13.6 0.4 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain CCAP PF11105.8 EFE38968.1 - 0.087 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a Pkinase PF00069.25 EFE38971.1 - 2.3e-11 43.6 0.0 1.5e-08 34.3 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain tRNA-synt_1g PF09334.11 EFE38973.1 - 5.5e-128 427.0 0.1 2.2e-127 425.0 0.1 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (M) Choline_transpo PF04515.12 EFE38975.1 - 1.7e-81 274.0 23.0 1.7e-81 274.0 23.0 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter Amidohydro_1 PF01979.20 EFE38977.1 - 1.1e-71 242.0 0.0 1.2e-71 241.8 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFE38977.1 - 2.3e-09 37.2 0.2 1.4e-06 28.1 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 EFE38977.1 - 0.0002 20.8 0.0 0.00033 20.1 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase Toxin_29 PF08116.11 EFE38977.1 - 0.035 14.1 0.3 0.1 12.6 0.3 1.8 1 0 0 1 1 1 0 PhTx neurotoxin family tRNA_int_end_N2 PF12928.7 EFE38977.1 - 0.055 13.7 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 tRNA-splicing endonuclease subunit sen54 N-term Sulfatase PF00884.23 EFE38978.1 - 6.6e-59 199.8 0.1 9.3e-59 199.3 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 EFE38978.1 - 6.5e-21 73.9 0.1 4.9e-20 71.1 0.0 2.2 1 1 1 2 2 2 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 EFE38978.1 - 1e-08 35.2 0.0 1.5e-07 31.4 0.0 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 EFE38978.1 - 0.025 14.9 0.0 0.059 13.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) Sulfatase_C PF14707.6 EFE38978.1 - 0.035 14.8 0.0 0.095 13.4 0.0 1.7 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase Peptidase_C16 PF01831.17 EFE38978.1 - 0.097 12.4 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase C16 family DUF229 PF02995.17 EFE38978.1 - 0.16 10.5 0.0 0.2 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Fungal_trans PF04082.18 EFE38979.1 - 8.5e-15 54.5 0.0 1.3e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE38979.1 - 2.9e-08 33.7 9.3 4.9e-08 33.0 9.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EFE38980.1 - 4.3e-42 144.3 55.1 4e-41 141.1 55.1 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3377 PF11857.8 EFE38980.1 - 0.043 13.7 0.1 0.043 13.7 0.1 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF3377) Strabismus PF06638.11 EFE38980.1 - 1.1 7.8 2.9 1.7 7.2 2.9 1.2 1 0 0 1 1 1 0 Strabismus protein Rota_NS53 PF00981.17 EFE38981.1 - 0.12 11.2 0.5 0.18 10.6 0.5 1.2 1 0 0 1 1 1 0 Rotavirus RNA-binding Protein 53 (NS53) Vps36-NZF-N PF16988.5 EFE38981.1 - 0.2 11.0 1.9 14 5.1 0.0 2.6 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 EFE38981.1 - 0.61 10.2 0.1 0.61 10.2 0.1 2.9 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger PHD PF00628.29 EFE38981.1 - 0.94 9.4 7.8 1.4 8.9 3.3 2.4 2 0 0 2 2 2 0 PHD-finger Sterol_MT_C PF08498.10 EFE38982.1 - 3.9e-28 97.6 0.2 6.5e-28 96.8 0.2 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EFE38982.1 - 5.4e-18 65.4 0.0 9.5e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE38982.1 - 6.8e-18 65.2 0.0 1.2e-17 64.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE38982.1 - 5.3e-16 58.8 0.0 7.8e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE38982.1 - 2.9e-11 43.5 0.0 4.8e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFE38982.1 - 5e-11 42.4 0.0 7.8e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EFE38982.1 - 1e-10 42.2 0.0 2.8e-10 40.8 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE38982.1 - 3.8e-09 36.2 0.0 6.2e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EFE38982.1 - 0.0012 18.7 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 EFE38982.1 - 0.0017 17.9 0.0 0.0026 17.4 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EFE38982.1 - 0.0023 17.4 0.0 0.004 16.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFE38982.1 - 0.0027 17.3 0.0 0.012 15.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EFE38982.1 - 0.0057 16.7 1.3 0.011 15.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFE38982.1 - 0.0059 16.1 0.0 0.018 14.5 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase RrnaAD PF00398.20 EFE38982.1 - 0.056 12.5 0.0 0.085 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_2 PF00891.18 EFE38982.1 - 0.056 12.7 0.0 0.082 12.2 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_24 PF13578.6 EFE38982.1 - 0.12 13.5 0.0 0.38 11.8 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain RRM_1 PF00076.22 EFE38983.1 - 6.6e-10 38.7 0.0 1.2e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFE38983.1 - 0.008 16.2 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EFE38983.1 - 0.056 13.3 0.0 0.098 12.5 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif RAC_head PF16717.5 EFE38984.1 - 1.1e-30 106.5 2.1 1.1e-30 106.5 2.1 3.1 3 1 0 3 3 3 1 Ribosome-associated complex head domain DnaJ PF00226.31 EFE38984.1 - 7.7e-18 64.4 0.9 2e-17 63.1 0.2 2.2 2 0 0 2 2 2 1 DnaJ domain Glyco_hydro_76 PF03663.14 EFE38985.1 - 5.1e-160 532.9 5.5 6e-160 532.7 5.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFE38985.1 - 9.2e-05 21.7 8.0 0.0085 15.2 0.1 3.1 2 1 0 3 3 3 3 Glycosyl Hydrolase Family 88 PFK PF00365.20 EFE38986.1 - 2.8e-192 637.2 0.1 1.4e-106 356.0 0.1 2.1 2 0 0 2 2 2 2 Phosphofructokinase DAGK_cat PF00781.24 EFE38986.1 - 0.044 13.4 0.1 0.17 11.5 0.1 2.0 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Med17 PF10156.9 EFE38987.1 - 1.4e-99 334.0 0.7 1.9e-99 333.4 0.7 1.2 1 0 0 1 1 1 1 Subunit 17 of Mediator complex Prenylcys_lyase PF07156.14 EFE38987.1 - 0.073 12.2 0.1 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 Prenylcysteine lyase ISN1 PF06437.11 EFE38988.1 - 8.6e-179 594.7 0.0 1.1e-178 594.4 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase eIF-5a PF01287.20 EFE38988.1 - 0.053 13.6 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold HNH_2 PF13391.6 EFE38989.1 - 9.6e-10 38.5 0.3 2.6e-09 37.1 0.3 1.8 1 0 0 1 1 1 1 HNH endonuclease p450 PF00067.22 EFE38990.1 - 3.6e-57 194.1 0.0 4.9e-57 193.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DHC_N1 PF08385.12 EFE38991.1 - 0.18 10.4 0.8 0.41 9.2 0.8 1.4 1 1 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 Fungal_trans_2 PF11951.8 EFE38992.1 - 2e-17 63.1 0.2 3.2e-17 62.4 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_33 PF10017.9 EFE38993.1 - 3.7e-71 239.8 0.0 4.8e-71 239.4 0.0 1.1 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent HECW1_helix PF18436.1 EFE38993.1 - 0.14 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 DAO PF01266.24 EFE38994.1 - 3.9e-28 99.0 0.0 9.8e-28 97.7 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Sacchrp_dh_NADP PF03435.18 EFE38994.1 - 5.4e-05 23.5 0.0 0.00024 21.4 0.0 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_9 PF13454.6 EFE38994.1 - 0.0014 18.6 0.0 0.13 12.3 0.0 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EFE38994.1 - 0.0027 17.9 0.0 0.0083 16.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 EFE38994.1 - 0.0093 16.2 0.0 0.02 15.2 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain K_oxygenase PF13434.6 EFE38994.1 - 0.018 14.2 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EFE38994.1 - 0.13 11.4 0.0 1.9 7.7 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase cNMP_binding PF00027.29 EFE38995.1 - 1.4e-29 102.0 2.3 2.1e-19 69.4 0.0 5.5 5 1 0 5 5 5 3 Cyclic nucleotide-binding domain Patatin PF01734.22 EFE38995.1 - 5e-17 62.8 10.8 5.9e-16 59.2 7.8 3.0 2 1 0 2 2 2 1 Patatin-like phospholipase zinc_ribbon_10 PF10058.9 EFE38996.1 - 1.1e-18 66.7 0.1 1.6e-18 66.2 0.1 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein Fusion_gly_K PF01621.17 EFE38996.1 - 0.19 10.8 0.6 0.25 10.4 0.6 1.1 1 0 0 1 1 1 0 Cell fusion glycoprotein K GRIP PF01465.20 EFE38997.1 - 7.9e-15 54.5 0.2 1.6e-14 53.5 0.2 1.6 1 0 0 1 1 1 1 GRIP domain GAS PF13851.6 EFE38997.1 - 8.8e-08 31.7 125.0 0.0044 16.4 12.4 8.4 3 2 5 8 8 8 6 Growth-arrest specific micro-tubule binding CALCOCO1 PF07888.11 EFE38997.1 - 8.8e-07 28.1 134.6 0.0034 16.3 22.8 5.5 3 1 2 5 5 5 3 Calcium binding and coiled-coil domain (CALCOCO1) like HMMR_N PF15905.5 EFE38997.1 - 1.9e-05 24.3 131.5 0.0039 16.7 12.5 8.3 3 2 5 8 8 8 4 Hyaluronan mediated motility receptor N-terminal CENP-F_leu_zip PF10473.9 EFE38997.1 - 5.5e-05 23.2 144.8 0.033 14.2 13.5 9.4 3 2 6 9 9 9 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 EFE38997.1 - 0.0004 20.4 45.2 0.15 12.1 5.5 7.1 6 2 1 7 7 7 2 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 EFE38997.1 - 0.00043 19.3 135.9 0.0012 17.8 17.6 7.9 3 2 3 7 7 7 3 Spc7 kinetochore protein Filament PF00038.21 EFE38997.1 - 0.00092 18.9 122.8 0.038 13.6 48.4 6.9 3 2 4 7 7 6 4 Intermediate filament protein FPP PF05911.11 EFE38997.1 - 0.0014 17.0 129.5 0.0079 14.5 15.7 6.3 1 1 5 7 7 7 4 Filament-like plant protein, long coiled-coil TMF_TATA_bd PF12325.8 EFE38997.1 - 0.0017 18.5 10.2 0.0017 18.5 10.2 11.3 5 3 7 12 12 11 4 TATA element modulatory factor 1 TATA binding TolA_bind_tri PF16331.5 EFE38997.1 - 0.0023 18.0 69.4 0.047 13.8 0.1 11.0 7 4 3 10 10 9 5 TolA binding protein trimerisation MAD PF05557.13 EFE38997.1 - 0.0029 16.0 124.0 0.0048 15.3 6.7 6.2 3 2 3 6 6 6 2 Mitotic checkpoint protein Lebercilin PF15619.6 EFE38997.1 - 0.0032 17.1 11.0 0.0032 17.1 11.0 7.8 4 2 4 8 8 7 3 Ciliary protein causing Leber congenital amaurosis disease Bap31_Bap29_C PF18035.1 EFE38997.1 - 0.0073 16.3 0.2 0.0073 16.3 0.2 10.2 9 2 0 9 9 8 2 Bap31/Bap29 cytoplasmic coiled-coil domain Myosin_tail_1 PF01576.19 EFE38997.1 - 0.023 12.5 135.4 0.0065 14.4 15.7 3.1 3 0 0 3 3 3 0 Myosin tail DUF4490 PF14892.6 EFE38997.1 - 0.076 13.1 0.1 0.5 10.5 0.1 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4490) VGPC1_C PF16799.5 EFE38997.1 - 0.17 11.9 12.9 0.24 11.4 0.9 4.1 3 0 0 3 3 3 0 C-terminal membrane-localisation domain of ion-channel, VCN1 EzrA PF06160.12 EFE38997.1 - 0.25 9.5 101.9 0.0055 14.9 45.9 6.9 3 2 2 5 5 5 0 Septation ring formation regulator, EzrA DUF3584 PF12128.8 EFE38997.1 - 0.36 8.3 117.7 0.0074 13.9 16.7 4.6 3 1 0 4 4 4 0 Protein of unknown function (DUF3584) DUF4201 PF13870.6 EFE38997.1 - 0.71 9.6 113.1 0.055 13.2 9.0 10.3 3 2 5 10 10 10 0 Domain of unknown function (DUF4201) Tropomyosin_1 PF12718.7 EFE38997.1 - 1.2 9.3 148.7 0.3 11.2 20.5 8.9 3 2 5 8 8 8 0 Tropomyosin like APG6_N PF17675.1 EFE38997.1 - 5.4 7.5 160.1 1.9 9.0 1.7 10.8 4 2 6 11 11 10 0 Apg6 coiled-coil region TPR_MLP1_2 PF07926.12 EFE38997.1 - 5.5 7.1 147.9 0.058 13.4 16.4 10.8 4 2 6 10 10 9 0 TPR/MLP1/MLP2-like protein DUF641 PF04859.12 EFE38997.1 - 5.7 7.3 104.8 0.14 12.5 11.4 10.8 6 4 5 11 11 10 0 Plant protein of unknown function (DUF641) ATG16 PF08614.11 EFE38997.1 - 7.7 6.7 163.3 0.073 13.3 26.4 9.5 3 3 3 8 8 7 0 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 EFE38997.1 - 9.1 6.1 126.7 0.063 13.1 6.8 8.8 3 2 5 8 8 8 0 Coiled-coil region of CCDC155 or KASH Acetyltransf_1 PF00583.25 EFE38998.1 - 3.6e-18 65.9 0.0 4.8e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFE38998.1 - 2e-08 34.5 0.0 4.7e-08 33.4 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE38998.1 - 1.1e-07 31.7 0.0 2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EFE38998.1 - 1.4e-06 28.3 0.0 2.3e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFE38998.1 - 6.2e-06 26.9 0.0 8e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFE38998.1 - 0.021 14.3 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_CG PF14542.6 EFE38998.1 - 0.038 14.1 0.0 0.071 13.2 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 EFE38998.1 - 0.14 12.3 0.0 0.33 11.1 0.0 1.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF2838 PF10998.8 EFE38999.1 - 0.016 15.4 1.3 0.032 14.5 1.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2838) JAB PF01398.21 EFE39000.1 - 1.2e-33 115.5 0.0 2.8e-33 114.4 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EFE39000.1 - 7.6e-12 45.6 0.2 1.2e-11 45.0 0.2 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EFE39000.1 - 8.7e-08 32.0 0.0 5.1e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain Hist_deacetyl PF00850.19 EFE39001.1 - 3.5e-82 276.3 0.1 7.4e-82 275.2 0.0 1.6 2 0 0 2 2 2 1 Histone deacetylase domain Ribosomal_L14 PF00238.19 EFE39002.1 - 3.7e-33 114.2 0.0 4e-33 114.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Endonuc-FokI_C PF09254.11 EFE39002.1 - 0.15 11.3 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal SH3_1 PF00018.28 EFE39003.1 - 2.2e-09 36.8 0.1 5e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 EFE39003.1 - 5.4e-09 36.5 0.1 5.2e-08 33.3 0.1 2.5 1 1 0 1 1 1 1 PH domain SAM_2 PF07647.17 EFE39003.1 - 2.5e-08 33.9 0.1 5.3e-08 32.9 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 EFE39003.1 - 8.2e-07 28.8 0.4 1.9e-06 27.6 0.4 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFE39003.1 - 0.00042 19.9 0.1 0.00091 18.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 EFE39003.1 - 0.0019 18.6 0.1 0.0037 17.7 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_11 PF15413.6 EFE39003.1 - 0.006 17.0 0.0 0.02 15.3 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EFE39003.1 - 0.11 12.7 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3824 PF12868.7 EFE39004.1 - 5 7.8 7.9 6.9 7.3 7.9 1.3 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) zf-MIZ PF02891.20 EFE39005.1 - 1.6e-10 40.6 0.1 3.6e-10 39.4 0.1 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger DUF5102 PF17104.5 EFE39006.1 - 2.5e-116 388.8 2.8 2.5e-116 388.8 2.8 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5102) DUF4543 PF15076.6 EFE39006.1 - 0.17 12.0 1.2 0.29 11.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4543) Nsp1_C PF05064.13 EFE39007.1 - 6.8e-43 145.2 3.6 1.6e-42 143.9 3.6 1.6 1 0 0 1 1 1 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EFE39007.1 - 0.0002 22.1 30.9 0.0002 22.1 30.9 6.6 1 1 3 4 4 2 1 Nucleoporin FG repeat region HIP1_clath_bdg PF16515.5 EFE39007.1 - 0.17 12.5 14.9 1.7 9.3 6.0 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Baculo_PEP_C PF04513.12 EFE39007.1 - 0.31 11.1 5.9 0.47 10.5 4.6 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus OmpH PF03938.14 EFE39007.1 - 0.31 11.4 12.2 1.7 9.0 0.1 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 EFE39007.1 - 0.32 10.3 8.7 0.6 9.4 8.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2935 PF11155.8 EFE39007.1 - 0.39 11.1 1.3 4 7.8 1.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) DUF4200 PF13863.6 EFE39007.1 - 0.44 11.0 11.7 0.25 11.8 6.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) FlaC_arch PF05377.11 EFE39007.1 - 0.74 10.2 9.1 1.1 9.7 0.4 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) AAA_13 PF13166.6 EFE39007.1 - 1.5 7.4 9.2 4.8 5.7 8.9 1.7 1 1 0 1 1 1 0 AAA domain CK2S PF15011.6 EFE39007.1 - 2.1 8.2 7.1 2.1 8.2 3.4 2.3 2 0 0 2 2 2 0 Casein Kinase 2 substrate Med21 PF11221.8 EFE39007.1 - 2.8 8.2 14.1 52 4.1 13.5 3.0 1 1 0 1 1 1 0 Subunit 21 of Mediator complex ParB PF08775.10 EFE39007.1 - 3.2 8.3 5.5 0.45 11.0 0.6 2.0 2 1 0 2 2 2 0 ParB family DUF1664 PF07889.12 EFE39007.1 - 3.5 7.7 9.6 1.9 8.5 0.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) FliT PF05400.13 EFE39007.1 - 3.9 8.3 6.4 1.8 9.5 1.3 2.6 1 1 1 2 2 2 0 Flagellar protein FliT ERM PF00769.19 EFE39007.1 - 4 7.2 12.0 6.8 6.4 12.0 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family IFT57 PF10498.9 EFE39007.1 - 4.1 6.3 12.3 0.77 8.7 6.0 2.0 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 Laminin_II PF06009.12 EFE39007.1 - 4.3 7.4 11.1 4.4 7.3 2.8 2.4 1 1 0 2 2 2 0 Laminin Domain II Spc7 PF08317.11 EFE39007.1 - 4.6 6.0 14.4 1.2 7.9 6.6 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein V-SNARE PF05008.15 EFE39007.1 - 4.7 7.6 10.0 1.4 9.3 0.7 3.2 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus GAT PF03127.14 EFE39007.1 - 5.5 7.4 7.1 7.5 6.9 0.2 2.8 1 1 1 2 2 2 0 GAT domain CREPT PF16566.5 EFE39007.1 - 8.8 6.5 8.0 1.2 9.3 1.7 2.2 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour 14-3-3 PF00244.20 EFE39008.1 - 9.5e-105 349.0 7.4 1.1e-104 348.8 7.4 1.1 1 0 0 1 1 1 1 14-3-3 protein DUF3461 PF11944.8 EFE39008.1 - 0.4 10.8 2.9 3.7 7.7 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3461) DUF2205 PF10224.9 EFE39009.1 - 1e-32 111.9 0.4 1e-32 111.9 0.4 1.6 2 0 0 2 2 2 1 Short coiled-coil protein YabA PF06156.13 EFE39009.1 - 0.017 15.7 0.3 0.029 15.0 0.3 1.3 1 0 0 1 1 1 0 Initiation control protein YabA DUF4208 PF13907.6 EFE39009.1 - 0.021 15.2 0.1 0.033 14.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) DivIC PF04977.15 EFE39009.1 - 0.027 14.3 0.4 0.043 13.6 0.4 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF4201 PF13870.6 EFE39009.1 - 0.027 14.2 0.4 0.038 13.7 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) CASP_C PF08172.12 EFE39009.1 - 0.038 13.3 0.9 0.038 13.3 0.9 2.0 2 0 0 2 2 2 0 CASP C terminal HALZ PF02183.18 EFE39009.1 - 0.043 14.0 2.8 0.097 12.9 0.2 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper PI3K_P85_iSH2 PF16454.5 EFE39009.1 - 0.048 13.2 0.2 0.061 12.9 0.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Prefoldin PF02996.17 EFE39009.1 - 0.073 13.0 0.6 0.11 12.4 0.6 1.4 1 0 0 1 1 1 0 Prefoldin subunit NAM-associated PF14303.6 EFE39009.1 - 4.4 8.0 9.4 10 6.8 9.3 1.7 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain Aminotran_1_2 PF00155.21 EFE39011.1 - 1.1e-74 251.8 0.0 1.3e-74 251.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4246 PF14033.6 EFE39012.1 - 3.1e-173 577.1 0.2 3.7e-173 576.8 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 EFE39012.1 - 0.00057 20.3 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase DJ-1_PfpI PF01965.24 EFE39013.1 - 8e-22 77.8 0.0 1.1e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EFE39013.1 - 0.0088 15.8 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 EFE39013.1 - 0.2 11.2 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain IMS PF00817.20 EFE39014.1 - 3.2e-40 137.6 0.0 7.3e-40 136.4 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 EFE39014.1 - 4.4e-24 84.7 0.1 1.1e-23 83.4 0.0 1.8 2 0 0 2 2 1 1 DNA repair protein REV1 C-terminal domain UBM PF14377.6 EFE39014.1 - 8.1e-15 53.7 12.3 4.4e-09 35.5 2.6 4.1 3 0 0 3 3 3 3 Ubiquitin binding region IMS_C PF11799.8 EFE39014.1 - 9.4e-15 55.4 0.0 2.4e-14 54.0 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 EFE39014.1 - 3.8e-10 40.0 0.0 1.2e-09 38.5 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFE39014.1 - 5.1e-07 30.0 0.0 2.6e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EFE39014.1 - 1.9e-06 28.1 0.0 4.4e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain mCpol PF18182.1 EFE39014.1 - 0.0003 21.1 0.1 0.0013 19.1 0.0 2.1 2 0 0 2 2 2 1 minimal CRISPR polymerase domain IMS_HHH PF11798.8 EFE39014.1 - 0.012 15.9 0.1 0.092 13.1 0.0 2.6 2 0 0 2 2 2 0 IMS family HHH motif PTCB-BRCT PF12738.7 EFE39014.1 - 0.027 14.4 0.0 0.059 13.3 0.0 1.6 1 0 0 1 1 1 0 twin BRCT domain CSTF_C PF14304.6 EFE39014.1 - 0.039 13.6 1.0 9.8 5.9 0.0 3.3 3 0 0 3 3 3 0 Transcription termination and cleavage factor C-terminal DUF1805 PF08827.11 EFE39014.1 - 0.086 13.2 0.0 0.3 11.4 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) FKBP_C PF00254.28 EFE39015.1 - 1.3e-30 105.6 0.0 5.3e-30 103.6 0.0 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 EFE39015.1 - 2.2e-29 102.1 4.6 2.2e-29 102.1 4.6 2.8 2 2 0 2 2 2 1 Nucleoplasmin-like domain Utp14 PF04615.13 EFE39015.1 - 0.79 8.2 46.3 1.3 7.5 46.3 1.5 1 1 0 1 1 1 0 Utp14 protein PPP1R35_C PF15503.6 EFE39015.1 - 9.7 6.0 9.3 0.5 10.2 2.2 2.0 1 1 1 2 2 2 0 Protein phosphatase 1 regulatory subunit 35 C-terminus Pkinase PF00069.25 EFE39016.1 - 9.1e-48 162.9 1.2 1.8e-25 89.9 0.1 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39016.1 - 3e-20 72.6 0.0 5.7e-13 48.7 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFE39016.1 - 0.024 13.6 0.4 0.055 12.4 0.4 1.5 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EFE39016.1 - 0.026 14.5 0.1 0.062 13.2 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3591 PF12157.8 EFE39017.1 - 4.5e-186 618.8 0.5 6e-186 618.4 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC PF00098.23 EFE39017.1 - 0.0055 16.7 0.7 0.0097 16.0 0.7 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 EFE39017.1 - 0.17 11.8 1.0 0.4 10.6 1.0 1.7 1 0 0 1 1 1 0 Zinc knuckle Methyltransf_15 PF09445.10 EFE39018.1 - 1e-41 142.3 0.0 1.6e-41 141.6 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 EFE39018.1 - 2.1e-08 34.0 0.0 3.1e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Met_10 PF02475.16 EFE39018.1 - 1.1e-07 31.8 0.0 1.5e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.18 EFE39018.1 - 2.6e-06 27.3 0.0 4.2e-06 26.6 0.0 1.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_5 PF01795.19 EFE39018.1 - 0.0045 16.6 0.0 0.0067 16.0 0.0 1.2 1 0 0 1 1 1 1 MraW methylase family Methyltransf_18 PF12847.7 EFE39018.1 - 0.0056 16.6 0.0 0.008 16.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE39018.1 - 0.017 15.8 0.0 0.028 15.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 EFE39018.1 - 0.05 12.8 0.0 0.073 12.2 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_11 PF08241.12 EFE39018.1 - 0.059 14.0 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EFE39018.1 - 0.077 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain GRASP55_65 PF04495.14 EFE39019.1 - 9e-39 132.9 0.0 6e-38 130.3 0.0 1.9 1 1 1 2 2 2 1 GRASP55/65 PDZ-like domain ApoO PF09769.9 EFE39020.1 - 1.4e-41 141.5 0.2 2.8e-41 140.5 0.1 1.5 2 0 0 2 2 2 1 Apolipoprotein O Vert_HS_TF PF06546.11 EFE39020.1 - 0.61 9.7 5.2 0.8 9.3 5.2 1.1 1 0 0 1 1 1 0 Vertebrate heat shock transcription factor Peptidase_M3 PF01432.20 EFE39021.1 - 2e-119 399.9 0.0 2.8e-119 399.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Methyltransf_23 PF13489.6 EFE39022.1 - 9.4e-27 93.9 0.0 1.4e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE39022.1 - 8.3e-10 39.3 0.0 1.9e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE39022.1 - 1.6e-09 37.7 0.0 1.9e-08 34.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE39022.1 - 4.1e-07 30.7 0.0 1.1e-06 29.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE39022.1 - 2.9e-06 27.8 0.0 5.7e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFE39022.1 - 0.00098 18.6 0.9 0.0025 17.3 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase CMAS PF02353.20 EFE39022.1 - 0.02 14.2 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EFE39022.1 - 0.035 13.4 0.0 0.3 10.4 0.0 2.3 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EFE39022.1 - 0.045 13.1 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFE39022.1 - 0.16 11.5 0.0 2 7.9 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.9 EFE39022.1 - 0.2 11.4 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Proteasome PF00227.26 EFE39024.1 - 7.8e-48 162.5 0.1 9.5e-48 162.2 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EFE39024.1 - 7.4e-15 54.1 0.1 7.4e-15 54.1 0.1 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal NUP214 PF16755.5 EFE39025.1 - 6.4e-10 38.8 0.0 1.1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 ANAPC4_WD40 PF12894.7 EFE39025.1 - 4.9e-06 26.7 0.0 0.0017 18.6 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Syntaxin-6_N PF09177.11 EFE39025.1 - 0.017 15.7 0.1 0.049 14.2 0.1 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Fungal_trans PF04082.18 EFE39026.1 - 1.7e-13 50.2 0.2 3.2e-13 49.3 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE39026.1 - 2e-07 31.0 9.4 3.6e-07 30.2 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PI-PLC-Y PF00387.19 EFE39027.1 - 0.051 13.9 0.1 0.14 12.5 0.1 1.7 2 0 0 2 2 2 0 Phosphatidylinositol-specific phospholipase C, Y domain Acetyltransf_1 PF00583.25 EFE39028.1 - 6.6e-08 32.8 0.1 9.3e-08 32.3 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFE39028.1 - 8.5e-08 32.5 0.0 1.4e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFE39028.1 - 6.6e-06 26.1 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE39028.1 - 0.00011 22.3 0.0 0.0016 18.5 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE39028.1 - 0.02 14.8 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein GAD-like PF08887.11 EFE39028.1 - 0.045 13.5 0.1 0.084 12.7 0.1 1.4 1 0 0 1 1 1 0 GAD-like domain MOZ_SAS PF01853.18 EFE39028.1 - 0.11 12.2 0.0 0.77 9.4 0.0 1.9 2 0 0 2 2 2 0 MOZ/SAS family AA_permease_2 PF13520.6 EFE39032.1 - 2.9e-51 174.7 28.2 3.6e-51 174.4 28.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE39032.1 - 2.9e-22 78.9 26.4 3.4e-22 78.7 26.4 1.0 1 0 0 1 1 1 1 Amino acid permease Trp_oprn_chp PF09534.10 EFE39032.1 - 0.038 13.8 0.5 0.075 12.8 0.5 1.5 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) KH_1 PF00013.29 EFE39033.1 - 1.8e-43 146.2 4.0 1e-17 63.7 0.2 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EFE39033.1 - 1.8e-11 43.7 2.0 0.011 15.5 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EFE39033.1 - 1.2e-05 25.1 0.3 0.78 9.7 0.1 3.3 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 EFE39033.1 - 0.00012 22.0 0.0 0.019 15.0 0.0 2.4 2 0 0 2 2 2 1 KH-like RNA-binding domain KH_5 PF13184.6 EFE39033.1 - 0.00039 20.5 7.9 0.21 11.7 0.2 3.3 3 0 0 3 3 3 2 NusA-like KH domain Pol_alpha_B_N PF08418.10 EFE39033.1 - 0.016 15.2 0.5 0.026 14.5 0.5 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal CENP-K PF11802.8 EFE39034.1 - 0.00014 21.6 7.5 0.4 10.2 8.1 2.6 2 1 0 2 2 2 2 Centromere-associated protein K CitT PF12431.8 EFE39034.1 - 0.025 14.9 0.0 2.2 8.8 0.0 2.7 2 0 0 2 2 2 0 Transcriptional regulator APC_rep PF18797.1 EFE39034.1 - 0.037 14.9 1.1 0.18 12.8 0.1 2.6 2 0 0 2 2 2 0 Adenomatous polyposis coli (APC) repeat EpmC PF04315.12 EFE39034.1 - 0.11 12.2 0.3 3.1 7.5 0.1 2.4 2 0 0 2 2 2 0 Elongation factor P hydroxylase Spc7 PF08317.11 EFE39034.1 - 0.53 9.1 18.5 0.084 11.7 9.3 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Muted PF14942.6 EFE39034.1 - 1.9 8.8 14.7 0.51 10.7 7.4 2.6 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein ARD PF03079.14 EFE39034.1 - 4.7 7.4 8.7 0.62 10.2 2.7 2.3 2 0 0 2 2 2 0 ARD/ARD' family APG6_N PF17675.1 EFE39034.1 - 5.4 7.5 24.4 0.065 13.8 4.4 3.6 2 1 2 4 4 4 0 Apg6 coiled-coil region CDC37_N PF03234.14 EFE39034.1 - 8.4 7.3 17.4 9.1 7.2 0.4 3.1 3 1 0 3 3 3 0 Cdc37 N terminal kinase binding Abhydrolase_1 PF00561.20 EFE39035.1 - 3.2e-14 53.2 0.0 4.9e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE39035.1 - 1.1e-08 34.6 0.0 2.3e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFE39035.1 - 0.0011 19.7 0.1 0.002 18.8 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase PF00756.20 EFE39035.1 - 0.008 15.8 0.0 0.03 14.0 0.0 1.8 2 0 0 2 2 2 1 Putative esterase Peptidase_S9 PF00326.21 EFE39035.1 - 0.054 13.0 0.0 0.19 11.2 0.0 1.9 1 1 0 1 1 1 0 Prolyl oligopeptidase family Methyltransf_25 PF13649.6 EFE39036.1 - 2.9e-10 40.7 0.0 8.1e-10 39.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE39036.1 - 1.3e-08 35.4 0.2 1.5e-06 28.8 0.2 2.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE39036.1 - 1.9e-05 24.1 0.0 0.00011 21.6 0.0 2.2 2 1 1 3 3 3 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFE39036.1 - 3.6e-05 23.6 0.0 7.2e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE39036.1 - 0.00036 21.2 0.0 0.00073 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE39036.1 - 0.0025 17.6 0.0 0.016 15.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFE39036.1 - 0.006 16.2 0.0 0.033 13.7 0.1 2.0 1 1 1 2 2 2 1 Methyltransferase small domain DUF2139 PF09910.9 EFE39036.1 - 0.051 12.7 0.0 0.073 12.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2139) SnoaL_2 PF12680.7 EFE39037.1 - 0.0002 21.9 0.0 0.00051 20.6 0.0 1.6 1 1 0 1 1 1 1 SnoaL-like domain DUF4342 PF14242.6 EFE39038.1 - 0.045 13.7 0.0 0.081 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) AMP-binding PF00501.28 EFE39039.1 - 4.1e-125 417.7 0.0 1.9e-75 254.1 0.2 2.3 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EFE39039.1 - 1.9e-76 257.6 0.0 7e-41 140.4 0.0 2.1 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EFE39039.1 - 1.6e-22 79.6 0.1 5.6e-11 42.6 0.0 3.1 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE39039.1 - 0.0076 17.2 0.0 5.2 8.1 0.0 3.1 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Transferase PF02458.15 EFE39039.1 - 0.049 12.3 0.0 0.099 11.3 0.0 1.4 1 0 0 1 1 1 0 Transferase family Beta-lactamase PF00144.24 EFE39040.1 - 9.5e-49 166.4 0.0 1.4e-48 165.9 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 EFE39040.1 - 1.4e-06 28.7 0.0 6.8e-06 26.5 0.0 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3471) DUF4952 PF16310.5 EFE39041.1 - 0.011 16.0 1.0 0.032 14.5 1.0 1.7 1 0 0 1 1 1 0 Domian of unknown function (DUF4952) SNF2_N PF00176.23 EFE39042.1 - 1.2e-45 155.7 0.0 1.7e-45 155.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE39042.1 - 2.5e-15 56.8 0.0 1e-14 54.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EFE39042.1 - 0.00013 21.2 0.0 0.00065 19.0 0.0 2.0 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EFE39042.1 - 0.0024 17.9 0.0 0.0047 17.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Vac14_Fab1_bd PF12755.7 EFE39043.1 - 8.7e-44 148.1 0.1 2.9e-40 136.8 0.0 4.0 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region Vac14_Fig4_bd PF11916.8 EFE39043.1 - 4.8e-23 81.7 0.8 2.4e-22 79.5 0.2 2.2 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding HEAT_EZ PF13513.6 EFE39043.1 - 6.4e-09 36.1 3.9 0.037 14.5 0.0 5.6 4 2 1 5 5 5 2 HEAT-like repeat HEAT PF02985.22 EFE39043.1 - 3.9e-06 26.7 0.2 0.41 11.0 0.0 6.1 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 EFE39043.1 - 0.0013 18.8 0.3 0.19 11.7 0.0 3.3 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 EFE39043.1 - 0.047 12.8 0.0 12 4.9 0.0 3.4 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal APH PF01636.23 EFE39044.1 - 1.4e-11 44.8 0.0 3.3e-11 43.6 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE39044.1 - 2.5e-05 23.3 0.1 0.00014 20.9 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 EFE39044.1 - 0.0013 18.1 0.0 0.0031 16.9 0.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase Glyco_hydro_47 PF01532.20 EFE39046.1 - 4.6e-177 589.5 0.0 5.4e-177 589.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 APG9 PF04109.16 EFE39047.1 - 6e-192 638.9 11.1 2e-180 600.9 6.1 2.1 1 1 1 2 2 2 2 Autophagy protein Apg9 DUF4719 PF15843.5 EFE39047.1 - 5.2 7.1 6.0 1.2 9.3 1.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4719) Folate_carrier PF01770.18 EFE39049.1 - 0.41 9.3 3.3 0.074 11.8 0.2 1.3 2 0 0 2 2 2 0 Reduced folate carrier FAM176 PF14851.6 EFE39049.1 - 0.66 9.6 4.8 0.2 11.3 0.6 1.9 2 0 0 2 2 2 0 FAM176 family PaREP1 PF05942.11 EFE39049.1 - 1.1 9.2 10.4 0.11 12.4 3.6 2.1 2 0 0 2 2 2 0 Archaeal PaREP1/PaREP8 family Eapp_C PF10238.9 EFE39049.1 - 3.4 7.7 10.9 0.22 11.6 1.1 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein DNApol_Exo PF18136.1 EFE39049.1 - 3.8 6.6 7.0 0.08 12.1 0.6 1.5 2 0 0 2 2 2 0 DNA mitochondrial polymerase exonuclease domain OAD_gamma PF04277.13 EFE39049.1 - 8.7 7.0 8.6 0.9 10.2 3.2 1.9 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain RRM_1 PF00076.22 EFE39050.1 - 2.8e-46 155.2 0.8 1.3e-13 50.5 0.6 5.5 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFE39050.1 - 3.9e-36 122.8 0.0 5.2e-29 99.9 0.0 4.6 5 0 0 5 5 5 3 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EFE39050.1 - 5.8e-05 23.0 0.0 0.018 15.0 0.1 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif TPR_14 PF13428.6 EFE39050.1 - 0.15 12.9 4.2 11 7.2 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat WD40 PF00400.32 EFE39053.1 - 4.2e-42 141.3 11.0 5.6e-09 36.5 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39053.1 - 5.7e-14 52.2 0.0 0.0053 17.0 0.0 5.7 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFE39053.1 - 3.2e-07 30.0 0.0 0.062 12.6 0.0 3.3 1 1 2 3 3 3 3 WD40-like domain Tup_N PF08581.10 EFE39053.1 - 5e-06 26.7 0.4 0.008 16.5 0.2 2.2 2 0 0 2 2 2 2 Tup N-terminal Cytochrom_D1 PF02239.16 EFE39053.1 - 2.6e-05 23.0 0.8 0.00025 19.7 0.4 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 EFE39053.1 - 6e-05 21.9 0.1 0.22 10.1 0.0 3.0 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFE39053.1 - 6.9e-05 22.0 0.1 0.75 8.7 0.0 3.8 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein MMS1_N PF10433.9 EFE39053.1 - 0.012 14.3 0.0 2.3 6.7 0.0 2.2 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term PD40 PF07676.12 EFE39053.1 - 0.017 15.1 0.0 19 5.3 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 EFE39053.1 - 0.022 14.1 0.0 6.3 6.0 0.0 2.5 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal eIF2A PF08662.11 EFE39053.1 - 0.027 14.4 0.0 0.11 12.4 0.0 1.7 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A FA_hydroxylase PF04116.13 EFE39054.1 - 2.4e-25 89.4 18.3 2.7e-25 89.2 15.2 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily MIF4G_like PF09088.11 EFE39055.1 - 2.6e-88 294.8 0.2 5.7e-88 293.7 0.2 1.6 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 EFE39055.1 - 3e-72 243.3 0.0 4.4e-72 242.8 0.0 1.3 1 0 0 1 1 1 1 MIF4G like TonB_dep_Rec PF00593.24 EFE39055.1 - 0.24 11.2 0.2 0.36 10.6 0.2 1.1 1 0 0 1 1 1 0 TonB dependent receptor Pkinase PF00069.25 EFE39056.1 - 1.5e-59 201.5 0.0 2.3e-59 200.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39056.1 - 2e-21 76.5 0.0 3.6e-21 75.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE39056.1 - 4.7e-06 26.1 0.0 9.9e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFE39056.1 - 0.0022 17.9 0.2 0.021 14.7 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Trypan_PARP PF05887.11 EFE39058.1 - 3 7.8 10.7 3.9 7.5 10.7 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) AA_permease_2 PF13520.6 EFE39059.1 - 2.6e-17 62.8 18.4 3.5e-17 62.4 18.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE39059.1 - 1.9e-06 26.8 14.4 2.5e-06 26.4 14.4 1.1 1 0 0 1 1 1 1 Amino acid permease YlaH PF14036.6 EFE39059.1 - 0.00045 20.5 2.3 0.00085 19.6 2.3 1.4 1 0 0 1 1 1 1 YlaH-like protein Tweety PF04906.13 EFE39059.1 - 4.1 6.0 4.5 6.5 5.3 0.2 2.0 2 0 0 2 2 2 0 Tweety AA_permease_2 PF13520.6 EFE39060.1 - 3.5e-23 82.1 19.3 4.2e-23 81.9 19.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE39060.1 - 4.3e-12 45.4 19.1 5.2e-12 45.1 19.1 1.1 1 0 0 1 1 1 1 Amino acid permease CBM_19 PF03427.13 EFE39060.1 - 0.038 14.0 0.6 0.086 12.8 0.6 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) Acetyltransf_3 PF13302.7 EFE39061.1 - 1.6e-17 64.4 0.0 3e-17 63.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE39061.1 - 2.9e-08 33.9 0.0 4.5e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFE39061.1 - 0.0022 17.9 0.0 0.0042 17.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Glyco_hydro_47 PF01532.20 EFE39063.1 - 6e-144 480.4 0.0 6.8e-144 480.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Histidinol_dh PF00815.20 EFE39064.1 - 1.3e-123 413.0 4.9 2.2e-123 412.3 4.9 1.3 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 EFE39064.1 - 1.8e-23 82.1 0.1 3.7e-23 81.1 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 EFE39064.1 - 3e-14 53.2 0.0 1.2e-13 51.3 0.1 2.1 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase Complex1_49kDa PF00346.19 EFE39065.1 - 2.1e-117 391.0 0.0 3.3e-117 390.4 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EFE39065.1 - 0.007 15.3 0.0 0.012 14.6 0.0 1.3 1 1 0 1 1 1 1 Nickel-dependent hydrogenase RNA_pol_A_bac PF01000.26 EFE39066.1 - 3.3e-27 95.1 0.0 5.8e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFE39066.1 - 6.5e-19 67.1 0.0 8.8e-19 66.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain ThiF PF00899.21 EFE39067.1 - 8.4e-46 156.3 0.0 1.9e-45 155.1 0.0 1.5 1 1 1 2 2 2 1 ThiF family E2_bind PF08825.10 EFE39067.1 - 1.9e-29 101.6 0.5 3.2e-29 100.9 0.5 1.4 1 0 0 1 1 1 1 E2 binding domain E1_UFD PF09358.10 EFE39067.1 - 0.0018 18.9 0.1 0.0055 17.4 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin fold domain Ecm33 PF12454.8 EFE39067.1 - 0.027 14.6 2.0 0.055 13.6 2.0 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein SNCAIP_SNCA_bd PF16700.5 EFE39067.1 - 0.1 12.3 0.1 0.24 11.1 0.1 1.5 1 0 0 1 1 1 0 Synphilin-1 alpha-Synuclein-binding domain UBA_e1_thiolCys PF10585.9 EFE39067.1 - 0.22 11.4 4.2 4.4 7.1 0.1 2.7 2 1 0 2 2 2 0 Ubiquitin-activating enzyme active site Rad50_zn_hook PF04423.14 EFE39067.1 - 2.8 7.9 5.4 10 6.0 0.4 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif Telomere_reg-2 PF10193.9 EFE39068.1 - 2.1e-27 95.7 0.0 1.4e-26 93.1 0.0 2.4 2 0 0 2 2 2 1 Telomere length regulation protein HTH_13 PF11972.8 EFE39068.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain Limkain-b1 PF11608.8 EFE39068.1 - 0.17 12.0 0.0 1.1 9.4 0.0 2.4 3 0 0 3 3 3 0 Limkain b1 Fungal_trans PF04082.18 EFE39069.1 - 9.4e-23 80.6 0.1 1.5e-22 79.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_2 PF00890.24 EFE39070.1 - 8.2e-46 156.9 0.1 6.2e-45 154.0 0.1 1.9 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EFE39070.1 - 2.9e-08 33.5 0.1 4.6e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EFE39070.1 - 1.3e-06 28.3 7.1 1.3e-06 28.2 1.2 2.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFE39070.1 - 9.3e-06 24.6 2.6 0.00085 18.1 0.1 3.1 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox_2 PF07992.14 EFE39070.1 - 1e-05 24.9 0.2 0.0012 18.1 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFE39070.1 - 0.00087 18.6 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EFE39070.1 - 0.0023 17.1 0.4 0.0023 17.1 0.4 2.7 3 0 0 3 3 3 1 Glucose inhibited division protein A Thi4 PF01946.17 EFE39070.1 - 0.0052 16.0 0.1 0.0098 15.1 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFE39070.1 - 0.0088 15.3 0.1 0.075 12.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFE39070.1 - 0.025 14.8 0.1 0.089 13.0 0.1 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EFE39070.1 - 0.1 11.6 0.1 0.17 10.9 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein API5 PF05918.11 EFE39071.1 - 6.1 5.5 7.6 6.3 5.5 7.6 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) PVL_ORF50 PF07768.11 EFE39072.1 - 0.0043 17.3 3.9 0.0048 17.2 3.9 1.1 1 0 0 1 1 1 1 PVL ORF-50-like family SHR3_chaperone PF08229.11 EFE39072.1 - 0.21 10.6 1.0 0.25 10.3 1.0 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 RabGAP-TBC PF00566.18 EFE39072.1 - 0.21 11.2 0.5 0.22 11.2 0.5 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Tmemb_161AB PF10268.9 EFE39072.1 - 0.25 10.0 0.7 0.25 9.9 0.7 1.0 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB Ferlin_C PF16165.5 EFE39072.1 - 0.27 11.1 5.3 0.32 10.9 5.3 1.1 1 0 0 1 1 1 0 Ferlin C-terminus Peptidase_S49_N PF08496.10 EFE39072.1 - 0.5 10.4 7.4 0.59 10.2 7.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Gyro_capsid PF04162.12 EFE39072.1 - 0.84 8.1 3.8 0.84 8.1 3.8 1.0 1 0 0 1 1 1 0 Gyrovirus capsid protein (VP1) SR-25 PF10500.9 EFE39072.1 - 0.9 9.1 15.5 1.1 8.9 15.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 EFE39072.1 - 1.1 9.5 12.3 1.3 9.3 12.3 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Med19 PF10278.9 EFE39072.1 - 1.4 8.9 15.1 1.6 8.6 15.1 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF3915 PF13054.6 EFE39072.1 - 2 8.4 5.6 3.3 7.7 5.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) ERK-JNK_inhib PF15002.6 EFE39072.1 - 4.6 6.9 12.5 5.2 6.7 12.5 1.1 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor NARP1 PF12569.8 EFE39072.1 - 5 5.9 9.3 5.6 5.8 9.3 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2252 PF10009.9 EFE39073.1 - 0.034 13.2 0.1 0.043 12.9 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Hpt PF01627.23 EFE39074.1 - 0.00071 19.8 0.0 0.00089 19.5 0.0 1.2 1 0 0 1 1 1 1 Hpt domain Ribonuc_L-PSP PF01042.21 EFE39074.1 - 0.06 13.4 0.0 0.067 13.2 0.0 1.2 1 0 0 1 1 1 0 Endoribonuclease L-PSP DUF4448 PF14610.6 EFE39075.1 - 1.5e-36 125.9 0.0 2.5e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) LapA_dom PF06305.11 EFE39075.1 - 0.015 15.1 0.6 0.015 15.1 0.6 3.3 2 1 1 3 3 3 0 Lipopolysaccharide assembly protein A domain dsrm PF00035.26 EFE39076.1 - 0.18 12.5 0.0 0.29 11.9 0.0 1.4 1 0 0 1 1 1 0 Double-stranded RNA binding motif DUF4692 PF15763.5 EFE39076.1 - 0.29 11.6 1.4 0.4 11.1 0.6 1.6 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) Prenyltrans PF00432.21 EFE39077.1 - 2.3e-12 46.4 1.3 1.1e-06 28.2 0.4 3.0 3 1 0 3 3 3 2 Prenyltransferase and squalene oxidase repeat Prenyltrans PF00432.21 EFE39078.1 - 6.4 6.6 11.7 7 6.5 2.5 2.4 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat Zn_clus PF00172.18 EFE39081.1 - 0.0047 17.0 7.8 0.01 15.9 7.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.9 EFE39081.1 - 8.4 4.8 13.0 0.27 9.7 5.7 1.9 2 0 0 2 2 2 0 Macoilin family DUF5427 PF10310.9 EFE39082.1 - 9.8e-168 558.9 0.0 1.2e-167 558.6 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) Flu_M1_C PF08289.11 EFE39082.1 - 0.011 15.9 0.1 0.033 14.4 0.1 1.8 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain HA2 PF04408.23 EFE39084.1 - 1.7e-20 73.3 0.0 1.7e-20 73.3 0.0 2.9 3 0 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFE39084.1 - 4.9e-17 62.1 0.0 1.8e-16 60.2 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFE39084.1 - 7.5e-15 55.2 0.0 2.1e-14 53.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE39084.1 - 1.8e-06 27.9 0.2 4.1e-06 26.7 0.2 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EFE39084.1 - 0.00023 20.5 0.0 0.00046 19.5 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EFE39084.1 - 0.0003 21.1 0.1 0.00092 19.5 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFE39084.1 - 0.00063 19.5 0.0 0.0017 18.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFE39084.1 - 0.0017 17.5 0.0 0.011 14.9 0.0 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.6 EFE39084.1 - 0.0044 17.4 0.1 0.01 16.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EFE39084.1 - 0.0077 15.6 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_14 PF13173.6 EFE39084.1 - 0.014 15.5 0.1 0.067 13.2 0.1 2.1 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 EFE39084.1 - 0.018 14.7 0.3 0.055 13.1 0.3 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ResIII PF04851.15 EFE39084.1 - 0.034 14.1 0.0 10 6.1 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EFE39084.1 - 0.06 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain Glug PF07581.12 EFE39084.1 - 0.088 13.3 0.0 0.3 11.6 0.0 1.9 1 0 0 1 1 1 0 The GLUG motif PhoH PF02562.16 EFE39084.1 - 0.096 12.1 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EFE39084.1 - 0.13 12.2 0.8 1 9.2 0.1 2.4 3 0 0 3 3 3 0 NACHT domain AAA_7 PF12775.7 EFE39084.1 - 0.14 11.7 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 EFE39084.1 - 0.15 12.4 1.1 0.56 10.6 0.0 2.4 3 0 0 3 3 2 0 AAA ATPase domain AAA_23 PF13476.6 EFE39084.1 - 2.9 8.4 6.3 2.2 8.8 0.0 3.0 2 1 1 3 3 3 0 AAA domain RTC4 PF14474.6 EFE39085.1 - 8.2e-33 113.1 0.0 1.8e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 RTC4-like domain DUF726 PF05277.12 EFE39086.1 - 2e-127 424.8 2.9 2e-127 424.8 2.9 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF726) NUDIX PF00293.28 EFE39087.1 - 4.5e-06 26.7 0.0 1.1e-05 25.5 0.0 1.6 1 1 0 1 1 1 1 NUDIX domain Cobalamin_bind PF01122.19 EFE39087.1 - 0.045 12.7 0.0 0.067 12.1 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic cobalamin-binding protein Metallophos PF00149.28 EFE39088.1 - 6.9e-13 49.6 0.8 1.2e-12 48.8 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFE39088.1 - 4.5e-06 27.0 0.1 3.7e-05 24.0 0.1 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Mito_carr PF00153.27 EFE39089.1 - 4.2e-73 241.4 0.3 5.5e-25 87.1 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EFE39089.1 - 1.5e-13 51.0 5.7 6.8e-09 36.1 0.8 3.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EFE39089.1 - 2e-12 45.9 2.8 8.9e-07 28.4 0.1 5.3 5 0 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.32 EFE39089.1 - 3.8e-10 38.6 11.0 1e-06 27.8 0.1 5.4 6 0 0 6 6 6 3 EF hand EF-hand_8 PF13833.6 EFE39089.1 - 3.3e-06 26.8 0.8 2.6 8.0 0.0 4.9 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 EFE39089.1 - 4.4e-06 25.9 2.4 7e-05 22.1 0.1 3.3 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 EFE39089.1 - 0.15 12.4 0.0 28 5.1 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain ATP-synt_E PF05680.12 EFE39089.1 - 2.1 8.8 5.8 5.2 7.5 5.8 1.6 1 0 0 1 1 1 0 ATP synthase E chain RNA_polI_A34 PF08208.11 EFE39089.1 - 9.2 6.3 16.8 17 5.4 16.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 FMO-like PF00743.19 EFE39091.1 - 1.4e-11 43.5 0.1 3.3e-10 39.0 0.0 2.6 3 0 0 3 3 3 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EFE39091.1 - 3.3e-11 43.0 0.0 5.8e-10 38.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFE39091.1 - 7.2e-11 42.2 0.0 3.6e-07 30.3 0.0 3.0 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFE39091.1 - 9.1e-10 38.3 0.0 1.6e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE39091.1 - 7.3e-07 28.6 0.0 4.3e-06 26.1 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFE39091.1 - 0.00013 22.0 0.2 3.6 7.5 0.0 4.1 4 0 0 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 EFE39091.1 - 0.0022 17.7 0.2 0.1 12.2 0.0 2.4 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFE39091.1 - 0.013 16.0 0.1 8.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFE39091.1 - 0.037 13.1 0.0 14 4.5 0.0 2.9 3 0 0 3 3 3 0 Lycopene cyclase protein Shikimate_DH PF01488.20 EFE39091.1 - 0.039 14.0 0.0 0.41 10.7 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EFE39091.1 - 0.048 12.7 0.0 0.36 9.8 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain BSMAP PF12280.8 EFE39091.1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Brain specific membrane anchored protein Thi4 PF01946.17 EFE39091.1 - 0.15 11.3 0.7 0.47 9.7 0.1 2.0 2 0 0 2 2 2 0 Thi4 family Glyco_transf_25 PF01755.17 EFE39092.1 - 5e-05 23.3 0.0 0.44 10.4 0.0 2.7 3 0 0 3 3 3 2 Glycosyltransferase family 25 (LPS biosynthesis protein) CEP44 PF15007.6 EFE39093.1 - 0.18 11.9 0.0 0.27 11.4 0.0 1.2 1 0 0 1 1 1 0 Centrosomal spindle body, CEP44 Peptidase_M22 PF00814.25 EFE39094.1 - 1.5e-45 156.0 0.0 1.3e-40 139.9 0.0 3.4 2 1 0 2 2 2 2 Glycoprotease family Myb_DNA-bind_6 PF13921.6 EFE39095.1 - 3.8e-08 33.5 1.2 3.7e-07 30.3 0.3 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFE39095.1 - 2.6e-05 24.3 0.3 0.00026 21.1 0.0 2.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain AJAP1_PANP_C PF15298.6 EFE39096.1 - 0.025 14.8 0.0 0.033 14.4 0.0 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus EPL1 PF10513.9 EFE39097.1 - 1.2e-33 116.8 0.5 2.9e-31 109.0 0.0 2.6 2 0 0 2 2 2 1 Enhancer of polycomb-like zf-HC5HC2H_2 PF13832.6 EFE39097.1 - 1.1e-31 109.3 3.6 1.1e-31 109.3 3.6 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EFE39097.1 - 9.9e-28 96.2 1.3 9.9e-28 96.2 1.3 2.8 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EFE39097.1 - 5.4e-14 51.5 2.9 5.4e-14 51.5 2.9 2.6 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EFE39097.1 - 1.1e-08 34.8 9.8 1.1e-08 34.8 9.8 2.7 2 0 0 2 2 2 1 PHD-finger Bromodomain PF00439.25 EFE39097.1 - 0.0034 17.4 0.0 0.0076 16.3 0.0 1.5 1 0 0 1 1 1 1 Bromodomain zf-PHD-like PF15446.6 EFE39097.1 - 6.9 6.3 13.6 0.016 14.8 2.1 2.3 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_2 PF03107.16 EFE39097.1 - 7.6 6.9 17.0 9.1 6.7 5.2 2.7 2 0 0 2 2 2 0 C1 domain RRM_1 PF00076.22 EFE39098.1 - 4.2e-20 71.3 0.0 5.5e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFE39098.1 - 0.00014 21.5 0.0 0.00017 21.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dpy-30 PF05186.13 EFE39099.1 - 7.5e-05 22.3 0.0 0.00011 21.8 0.0 1.3 1 0 0 1 1 1 1 Dpy-30 motif VRR_NUC PF08774.11 EFE39100.1 - 2.1e-24 85.7 0.0 6.3e-24 84.1 0.0 1.8 1 0 0 1 1 1 1 VRR-NUC domain Ribosomal_S13_N PF08069.12 EFE39101.1 - 1e-29 102.3 0.2 1.7e-29 101.6 0.2 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EFE39101.1 - 1.8e-14 53.7 0.1 3.4e-14 52.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 EFE39101.1 - 0.016 15.2 0.1 0.026 14.4 0.1 1.5 1 1 0 1 1 1 0 'Paired box' domain Chromate_transp PF02417.15 EFE39102.1 - 4.4e-35 121.1 27.0 2.6e-31 108.9 13.8 2.5 3 0 0 3 3 3 2 Chromate transporter Pkinase PF00069.25 EFE39108.1 - 4.4e-10 39.4 0.0 2.6e-09 36.8 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39108.1 - 2e-06 27.3 0.0 2.5e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EFE39108.1 - 0.024 14.6 0.2 0.32 10.9 0.0 2.2 1 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EFE39108.1 - 0.039 13.3 0.0 0.08 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFE39108.1 - 0.28 9.9 0.0 0.41 9.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SMN PF06003.12 EFE39109.1 - 0.076 12.3 0.2 0.076 12.3 0.2 1.8 2 1 1 3 3 3 0 Survival motor neuron protein (SMN) WD40 PF00400.32 EFE39111.1 - 1.8e-25 88.7 0.7 5.9e-07 30.1 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39111.1 - 1.5e-13 50.8 0.0 0.0065 16.7 0.0 5.0 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE39111.1 - 0.0021 16.8 0.8 0.073 11.7 0.1 2.6 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Gmad1 PF10647.9 EFE39111.1 - 0.028 14.2 0.0 0.11 12.2 0.0 2.0 1 1 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain PQQ_2 PF13360.6 EFE39111.1 - 0.1 12.2 0.1 0.26 10.8 0.1 1.8 1 1 0 1 1 1 0 PQQ-like domain FTHFS PF01268.19 EFE39112.1 - 2.7e-250 831.3 0.0 5.6e-250 830.3 0.0 1.4 2 0 0 2 2 2 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EFE39112.1 - 1.6e-66 222.6 0.7 1.6e-66 222.6 0.7 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EFE39112.1 - 3.4e-28 98.2 0.1 7.4e-28 97.2 0.1 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 EFE39112.1 - 0.023 13.7 0.6 0.046 12.6 0.1 1.7 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family RTC_insert PF05189.13 EFE39114.1 - 2e-31 108.5 0.0 7e-31 106.8 0.0 1.9 2 0 0 2 2 2 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.21 EFE39114.1 - 3.3e-27 95.1 0.1 4.1e-27 94.8 0.1 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Peptidase_S9 PF00326.21 EFE39115.1 - 1.5e-50 171.6 0.0 2.6e-50 170.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 EFE39115.1 - 0.00011 21.0 0.0 0.03 13.0 0.0 2.2 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) DUF3189 PF11385.8 EFE39115.1 - 0.097 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3189) Sec63 PF02889.16 EFE39116.1 - 2.9e-166 551.0 0.1 1.3e-93 312.8 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EFE39116.1 - 3.2e-46 157.3 0.1 1.6e-27 96.4 0.0 3.3 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EFE39116.1 - 1.9e-29 102.1 0.2 5.1e-29 100.7 0.2 1.8 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 EFE39116.1 - 4e-22 79.0 0.0 5.1e-13 49.4 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFE39116.1 - 3.2e-10 40.3 0.0 1.2e-07 32.1 0.0 3.6 2 2 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFE39116.1 - 4.3e-06 27.0 0.1 0.0034 17.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 EFE39116.1 - 0.0015 18.0 0.0 0.084 12.3 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein T2SSE PF00437.20 EFE39116.1 - 0.023 13.8 0.0 1.5 7.8 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.6 EFE39116.1 - 0.07 13.5 0.1 23 5.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain MutS_V PF00488.21 EFE39117.1 - 4.3e-74 248.6 0.0 7.6e-74 247.8 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFE39117.1 - 6e-31 108.2 0.4 8.1e-20 71.8 0.0 2.7 1 1 1 2 2 2 2 MutS domain III MutS_I PF01624.20 EFE39117.1 - 1.2e-22 80.2 0.0 2.9e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EFE39117.1 - 5.8e-08 33.1 0.0 2.2e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 MutS domain II AAA_29 PF13555.6 EFE39117.1 - 0.056 13.2 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 EFE39117.1 - 0.058 13.4 0.0 0.23 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EFE39117.1 - 0.08 13.4 2.8 0.34 11.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain MutS_IV PF05190.18 EFE39117.1 - 0.089 13.1 0.2 0.59 10.5 0.1 2.3 2 0 0 2 2 2 0 MutS family domain IV AAA_27 PF13514.6 EFE39117.1 - 0.092 12.3 0.2 0.38 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Ureidogly_lyase PF04115.12 EFE39118.1 - 2.2e-57 193.9 0.0 2.8e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Ureidoglycolate lyase Catalase PF00199.19 EFE39119.1 - 5.9e-159 529.3 0.4 8.2e-159 528.8 0.4 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EFE39119.1 - 2.1e-12 47.0 0.0 4.7e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Rer1 PF03248.13 EFE39120.1 - 6.1e-50 169.3 4.6 7.2e-50 169.1 4.6 1.1 1 0 0 1 1 1 1 Rer1 family ECH_1 PF00378.20 EFE39121.1 - 1.4e-78 263.7 0.1 1.6e-78 263.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFE39121.1 - 1.6e-36 126.5 1.0 1.3e-33 117.0 0.3 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Nuc_deoxyri_tr2 PF15891.5 EFE39122.1 - 0.091 13.1 0.2 0.29 11.5 0.0 1.9 1 1 1 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like adh_short PF00106.25 EFE39123.1 - 2.8e-30 105.3 0.4 4.1e-30 104.7 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE39123.1 - 2.5e-24 86.1 0.4 3.1e-24 85.8 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE39123.1 - 5.7e-09 36.1 0.1 7.2e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EFE39123.1 - 0.011 15.2 0.0 0.17 11.2 0.0 2.0 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase CitX PF03802.14 EFE39123.1 - 0.11 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase BTB PF00651.31 EFE39124.1 - 3.9e-15 56.0 0.2 1.5e-14 54.1 0.2 1.8 2 0 0 2 2 2 1 BTB/POZ domain A_deaminase PF00962.22 EFE39125.1 - 3.3e-24 85.8 0.0 7.8e-24 84.6 0.0 1.7 2 0 0 2 2 2 1 Adenosine/AMP deaminase Acetyltransf_1 PF00583.25 EFE39126.1 - 0.0012 19.0 0.1 0.063 13.5 0.1 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE39126.1 - 0.0018 18.2 0.0 0.018 15.0 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE39126.1 - 0.016 15.6 0.0 0.04 14.3 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain CFEM PF05730.11 EFE39129.1 - 2.7e-15 56.2 9.6 3.7e-15 55.7 9.6 1.2 1 0 0 1 1 1 1 CFEM domain MGC-24 PF05283.11 EFE39129.1 - 0.054 13.9 6.0 0.081 13.4 6.0 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Citrate_bind PF16114.5 EFE39130.1 - 7.7e-87 289.4 0.0 1.2e-86 288.7 0.0 1.3 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 EFE39130.1 - 3.1e-07 30.2 0.0 4.9e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Phage_1_1 PF08200.11 EFE39130.1 - 0.63 10.5 6.8 1.2 9.6 6.8 1.4 1 0 0 1 1 1 0 Bacteriophage 1.1 Protein Citrate_synt PF00285.21 EFE39131.1 - 1.1e-15 57.6 0.0 9.2e-13 48.0 0.0 3.1 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 EFE39131.1 - 6.8e-13 48.7 0.1 1.2e-12 47.9 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 EFE39131.1 - 5.5e-12 46.2 0.1 2.4e-11 44.2 0.0 2.1 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.6 EFE39131.1 - 1.2e-05 25.1 0.1 0.00012 21.9 0.0 2.2 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain RNase_P_Rpp14 PF01900.19 EFE39132.1 - 4.6e-39 132.8 0.0 5.8e-39 132.5 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family ATP_bind_1 PF03029.17 EFE39133.1 - 2.7e-14 53.6 0.0 3.6e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Polysacc_deac_2 PF04748.13 EFE39133.1 - 0.065 12.4 0.0 0.085 12.0 0.0 1.2 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase ATP_bind_1 PF03029.17 EFE39134.1 - 1.6e-33 116.5 0.0 1.8e-33 116.3 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EFE39134.1 - 0.00046 19.2 0.0 0.00065 18.8 0.0 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_10 PF12846.7 EFE39134.1 - 0.0014 17.6 0.0 0.0017 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain KTI12 PF08433.10 EFE39134.1 - 0.0036 16.8 0.0 0.0041 16.6 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Fer4_NifH PF00142.18 EFE39134.1 - 0.0062 16.0 0.0 0.0074 15.8 0.0 1.1 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_16 PF13191.6 EFE39134.1 - 0.0067 16.8 0.0 0.008 16.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFE39134.1 - 0.012 15.9 0.0 0.013 15.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFE39134.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.6 EFE39134.1 - 0.016 15.6 0.1 0.027 14.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFE39134.1 - 0.017 15.5 0.0 0.021 15.2 0.0 1.2 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EFE39134.1 - 0.019 14.7 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EFE39134.1 - 0.02 14.7 0.0 0.027 14.3 0.0 1.2 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_31 PF13614.6 EFE39134.1 - 0.043 13.7 0.0 0.05 13.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFE39134.1 - 0.043 14.4 0.0 0.045 14.3 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFE39134.1 - 0.048 13.8 0.0 0.057 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFE39134.1 - 0.068 12.9 0.0 0.068 12.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EFE39134.1 - 0.079 12.7 0.0 0.098 12.4 0.0 1.1 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFE39134.1 - 0.094 12.7 0.0 0.12 12.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EFE39134.1 - 0.12 11.6 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin PPV_E1_C PF00519.17 EFE39134.1 - 0.15 10.9 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase T2SSE PF00437.20 EFE39134.1 - 0.16 11.0 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.22 EFE39134.1 - 0.16 11.6 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA PF00004.29 EFE39134.1 - 0.16 12.4 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFE39134.1 - 0.17 11.2 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI WD40 PF00400.32 EFE39135.1 - 1.6e-09 38.2 1.4 0.12 13.3 0.1 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat SARS_X4 PF08779.10 EFE39135.1 - 0.13 12.5 0.0 1.3 9.3 0.0 2.5 3 0 0 3 3 3 0 SARS coronavirus X4 like HNH_2 PF13391.6 EFE39136.1 - 2.6e-11 43.5 0.0 7e-11 42.1 0.0 1.8 1 0 0 1 1 1 1 HNH endonuclease DUF2457 PF10446.9 EFE39136.1 - 0.027 13.6 2.3 0.041 13.0 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) AMP-binding PF00501.28 EFE39138.1 - 1.4e-138 462.0 0.0 5.8e-74 249.2 0.0 3.2 2 1 1 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EFE39138.1 - 7.9e-121 403.9 0.0 3.1e-47 161.3 0.0 3.3 3 0 0 3 3 3 3 Condensation domain PP-binding PF00550.25 EFE39138.1 - 1.4e-28 99.0 2.8 1.4e-09 38.2 0.0 3.8 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE39138.1 - 0.0071 17.3 0.0 0.049 14.6 0.0 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ASC PF00858.24 EFE39138.1 - 0.041 12.8 0.1 0.078 11.9 0.1 1.3 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel TraD_N PF12615.8 EFE39138.1 - 0.8 10.5 5.0 15 6.4 0.3 3.4 3 0 0 3 3 3 0 F sex factor protein N terminal AMP-binding PF00501.28 EFE39139.1 - 1.6e-221 735.3 0.0 1.4e-78 264.4 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EFE39139.1 - 6.1e-136 453.7 0.0 3.3e-51 174.4 0.0 6.2 6 1 0 6 6 6 5 Condensation domain PP-binding PF00550.25 EFE39139.1 - 1.9e-27 95.4 1.6 4e-09 36.7 0.0 3.8 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE39139.1 - 7.2e-10 39.7 0.0 0.049 14.6 0.0 3.9 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain p450 PF00067.22 EFE39140.1 - 9.3e-61 206.0 0.0 1.2e-60 205.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1729 PF08354.10 EFE39141.1 - 2.9e-139 463.9 0.0 4.3e-139 463.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EFE39141.1 - 1.8e-63 214.9 0.0 1.3e-62 212.2 0.0 2.4 4 0 0 4 4 4 1 Acyl transferase domain FAS_meander PF17951.1 EFE39141.1 - 9.3e-38 129.3 0.0 2.5e-37 127.9 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydrat_N PF13452.6 EFE39141.1 - 6.6e-29 100.7 0.0 6.7e-27 94.2 0.0 2.6 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase SAT PF16073.5 EFE39141.1 - 4.9e-25 88.6 0.1 1.6e-24 87.0 0.1 1.9 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 EFE39141.1 - 9.6e-24 83.3 0.1 2e-23 82.3 0.1 1.5 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 EFE39141.1 - 0.022 14.7 1.2 0.054 13.5 0.2 2.2 2 0 0 2 2 2 0 N-terminal domain in fatty acid synthase subunit beta 4HBT_2 PF13279.6 EFE39142.1 - 1.4e-07 32.1 0.0 2.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily RTA1 PF04479.13 EFE39143.1 - 1e-44 152.7 4.7 1e-44 152.7 4.7 1.4 2 0 0 2 2 2 1 RTA1 like protein ABC_tran PF00005.27 EFE39144.1 - 3.1e-46 157.3 0.0 1.1e-25 90.7 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFE39144.1 - 5.4e-32 111.5 12.4 1.4e-21 77.4 3.5 2.6 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EFE39144.1 - 6e-12 45.5 4.3 0.0013 18.2 0.1 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFE39144.1 - 1.5e-09 38.1 3.8 0.2 11.4 0.0 4.3 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFE39144.1 - 3.1e-08 33.2 0.3 0.0063 16.2 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFE39144.1 - 7e-07 29.3 0.3 0.041 13.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase NB-ARC PF00931.22 EFE39144.1 - 9.4e-06 25.0 0.2 0.0038 16.4 0.0 2.7 2 1 0 2 2 2 1 NB-ARC domain AAA_23 PF13476.6 EFE39144.1 - 1.4e-05 25.7 0.8 0.063 13.8 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFE39144.1 - 8.6e-05 22.8 0.1 0.31 11.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EFE39144.1 - 9.9e-05 22.4 0.0 0.44 10.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EFE39144.1 - 0.00012 22.6 1.4 0.48 10.8 0.0 3.1 3 0 0 3 3 2 2 AAA ATPase domain AAA_5 PF07728.14 EFE39144.1 - 0.00015 21.8 0.1 17 5.4 0.0 4.5 3 1 1 4 4 4 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFE39144.1 - 0.00033 21.2 0.1 0.14 12.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EFE39144.1 - 0.00035 20.1 0.1 0.07 12.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_15 PF13175.6 EFE39144.1 - 0.001 18.9 2.3 0.48 10.1 0.3 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 EFE39144.1 - 0.0017 17.9 0.0 2.4 7.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EFE39144.1 - 0.0022 18.4 0.3 3.4 8.1 0.1 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFE39144.1 - 0.003 17.9 0.0 1.6 9.2 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 EFE39144.1 - 0.0031 17.5 0.6 0.54 10.2 0.0 3.7 4 0 0 4 4 4 1 NACHT domain Dynamin_N PF00350.23 EFE39144.1 - 0.0052 16.8 0.5 4.5 7.3 0.1 2.6 2 0 0 2 2 2 0 Dynamin family AAA_33 PF13671.6 EFE39144.1 - 0.0053 16.9 0.0 3.5 7.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EFE39144.1 - 0.0073 16.0 0.0 0.13 11.9 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain NTPase_1 PF03266.15 EFE39144.1 - 0.0094 15.9 0.4 2.4 8.0 0.1 2.5 2 0 0 2 2 2 1 NTPase DUF502 PF04367.13 EFE39144.1 - 0.018 14.9 0.6 6.9 6.6 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF502) DUF815 PF05673.13 EFE39144.1 - 0.019 14.2 0.1 0.77 8.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_30 PF13604.6 EFE39144.1 - 0.019 14.7 0.0 9.5 5.9 0.0 2.9 2 1 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFE39144.1 - 0.024 14.6 1.2 2.1 8.2 0.0 3.3 3 0 0 3 3 3 0 Rad17 P-loop domain T2SSE PF00437.20 EFE39144.1 - 0.028 13.5 0.2 5.1 6.1 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 EFE39144.1 - 0.029 14.6 0.1 4.8 7.4 0.0 3.0 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EFE39144.1 - 0.038 13.7 0.1 2.7 7.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EFE39144.1 - 0.06 13.0 0.1 11 5.6 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase_2 PF01637.18 EFE39144.1 - 0.061 13.2 0.2 0.25 11.2 0.0 2.1 3 0 0 3 3 1 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EFE39144.1 - 0.083 12.6 0.9 2.8 7.6 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein cobW PF02492.19 EFE39144.1 - 0.11 12.1 0.7 0.97 9.0 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 EFE39144.1 - 0.14 11.5 0.1 0.29 10.5 0.1 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region TsaE PF02367.17 EFE39144.1 - 0.16 12.0 0.1 30 4.6 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EFE39144.1 - 0.19 11.0 0.1 11 5.2 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.6 EFE39144.1 - 0.19 12.1 2.6 13 6.1 0.0 3.7 4 0 0 4 4 3 0 AAA domain AIG1 PF04548.16 EFE39144.1 - 0.22 10.8 0.9 8.6 5.6 0.0 2.9 3 0 0 3 3 3 0 AIG1 family G-alpha PF00503.20 EFE39144.1 - 0.23 10.6 0.1 2.4 7.2 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit Aminotran_4 PF01063.19 EFE39145.1 - 2.2e-22 80.0 0.0 1.1e-21 77.8 0.0 1.8 1 1 0 1 1 1 1 Amino-transferase class IV Fas_alpha_ACP PF18325.1 EFE39146.1 - 4.5e-55 186.4 0.0 1e-54 185.3 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 EFE39146.1 - 3.2e-37 128.1 0.0 6.8e-37 127.1 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 EFE39146.1 - 1.8e-19 70.3 0.0 3.4e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EFE39146.1 - 3e-12 46.6 0.0 7e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Rib_5-P_isom_A PF06026.14 EFE39147.1 - 1e-42 145.7 0.0 1.6e-42 145.0 0.0 1.3 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) ThiF PF00899.21 EFE39148.1 - 1.5e-09 37.6 0.0 6.6e-06 25.7 0.1 2.9 1 1 0 2 2 2 2 ThiF family Asp PF00026.23 EFE39150.1 - 3.4e-06 26.7 0.0 5e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Phage_holin_2_4 PF16082.5 EFE39150.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like SKG6 PF08693.10 EFE39150.1 - 0.91 9.0 5.4 1.8 8.0 5.4 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Cation_efflux PF01545.21 EFE39151.1 - 1.9e-29 102.8 13.4 4.4e-29 101.7 13.4 1.6 1 1 0 1 1 1 1 Cation efflux family MARVEL PF01284.23 EFE39151.1 - 5.7e-05 23.2 0.4 0.31 11.0 0.0 2.5 2 1 0 2 2 2 2 Membrane-associating domain EphA2_TM PF14575.6 EFE39151.1 - 0.031 15.1 1.1 3.8 8.5 0.0 3.3 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain DUF2946 PF11162.8 EFE39151.1 - 1.5 9.5 13.5 2.2 9.0 10.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2946) zf-MYND PF01753.18 EFE39152.1 - 1.6e-08 34.5 7.9 4e-08 33.2 7.9 1.7 1 0 0 1 1 1 1 MYND finger Ion_trans PF00520.31 EFE39152.1 - 2e-06 27.2 11.8 2e-06 27.2 11.8 1.6 2 0 0 2 2 2 1 Ion transport protein SRP-alpha_N PF04086.13 EFE39152.1 - 6.8 6.5 8.7 12 5.8 8.7 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Cyclin PF08613.11 EFE39154.1 - 9.4e-06 26.1 0.0 9.4e-06 26.1 0.0 2.9 3 1 0 3 3 3 1 Cyclin Cyclin_N PF00134.23 EFE39154.1 - 0.0031 17.3 0.0 0.0069 16.1 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Aminotran_4 PF01063.19 EFE39155.1 - 2.9e-23 82.9 0.0 3.5e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Sugar_tr PF00083.24 EFE39156.1 - 9.3e-86 288.4 18.1 1.1e-85 288.2 18.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE39156.1 - 1.7e-12 46.9 41.9 4.6e-09 35.7 13.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CDC14 PF08045.11 EFE39157.1 - 1e-130 435.0 0.2 1.2e-129 431.5 0.0 2.0 2 0 0 2 2 2 1 Cell division control protein 14, SIN component TOH_N PF12549.8 EFE39157.1 - 0.25 11.3 6.0 0.34 10.8 3.6 2.5 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal Methyltransf_25 PF13649.6 EFE39158.1 - 3.3e-16 59.8 0.0 6.1e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE39158.1 - 3e-15 56.6 0.0 5.6e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE39158.1 - 9.8e-13 48.7 0.0 1.6e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE39158.1 - 1.1e-12 48.0 0.0 1.5e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE39158.1 - 1.7e-10 41.0 0.0 2.2e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFE39158.1 - 6.3e-07 29.1 0.0 4.2e-06 26.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EFE39158.1 - 5.7e-06 25.8 0.0 8.5e-06 25.3 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EFE39158.1 - 0.00034 20.1 0.0 0.001 18.6 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase CMAS PF02353.20 EFE39158.1 - 0.0011 18.4 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EFE39158.1 - 0.0076 16.0 0.0 0.0092 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF938 PF06080.12 EFE39158.1 - 0.017 14.9 0.0 0.04 13.7 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF938) TehB PF03848.14 EFE39158.1 - 0.048 13.1 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB ADH_zinc_N PF00107.26 EFE39158.1 - 0.06 13.3 0.1 0.32 11.0 0.1 2.1 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_32 PF13679.6 EFE39158.1 - 0.062 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.13 EFE39158.1 - 0.077 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 RrnaAD PF00398.20 EFE39158.1 - 0.083 11.9 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_7 PF03492.15 EFE39158.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase GidB PF02527.15 EFE39158.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Pox_MCEL PF03291.16 EFE39158.1 - 0.22 10.6 0.0 2.7 7.0 0.0 2.1 2 0 0 2 2 2 0 mRNA capping enzyme GST_C_6 PF17171.4 EFE39159.1 - 1.1e-19 69.9 0.1 2e-19 69.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFE39159.1 - 1.2e-15 58.0 0.0 4.4e-15 56.2 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 EFE39159.1 - 1.5e-09 38.2 0.2 7.8e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein SAM35 PF10806.8 EFE39159.1 - 3.1e-05 24.2 0.0 0.0001 22.6 0.0 1.9 2 0 0 2 2 2 1 SAM35, subunit of SAM coomplex GST_C_2 PF13410.6 EFE39159.1 - 0.00083 19.3 0.1 0.0019 18.2 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain PBP1_TM PF14812.6 EFE39159.1 - 0.18 12.2 13.7 0.34 11.3 13.7 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 EFE39159.1 - 7.7 7.0 16.5 16 6.0 16.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Metallothio_2 PF01439.18 EFE39160.1 - 1.1 10.2 25.3 0.22 12.5 8.0 3.3 4 0 0 4 4 4 0 Metallothionein Roughex PF06020.11 EFE39160.1 - 7.6 5.5 7.3 12 4.8 7.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Urb2 PF10441.9 EFE39162.1 - 4.9e-65 219.3 2.6 2.3e-64 217.1 0.0 3.2 4 0 0 4 4 4 1 Urb2/Npa2 family A_deaminase PF00962.22 EFE39163.1 - 3.4e-16 59.5 0.0 5.9e-16 58.7 0.0 1.3 1 1 0 1 1 1 1 Adenosine/AMP deaminase p450 PF00067.22 EFE39164.1 - 4.8e-77 259.7 0.0 5.8e-77 259.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fer4_12 PF13353.6 EFE39164.1 - 0.084 13.1 0.0 0.2 11.9 0.0 1.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain Pkinase PF00069.25 EFE39166.1 - 2.7e-08 33.5 0.0 6.5e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39166.1 - 9.9e-08 31.6 0.0 1.7e-07 30.8 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE39166.1 - 1.1e-07 32.1 0.7 1.2e-05 25.4 0.3 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFE39166.1 - 0.018 14.4 0.0 0.034 13.4 0.0 1.4 1 1 0 1 1 1 0 Kinase-like RIO1 PF01163.22 EFE39166.1 - 0.075 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EFE39166.1 - 0.1 11.3 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 EFE39166.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 EFE39166.1 - 0.15 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 WD40 PF00400.32 EFE39167.1 - 3.1e-48 160.7 19.0 9e-09 35.8 0.3 8.6 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39167.1 - 7.6e-11 42.2 0.0 0.00017 21.8 0.0 4.5 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE39167.1 - 4.7e-07 28.8 0.1 0.035 12.7 0.0 3.9 4 0 0 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFE39167.1 - 0.00012 21.0 0.0 0.023 13.5 0.0 2.9 2 1 1 3 3 3 2 Nup133 N terminal like Pox_A_type_inc PF04508.12 EFE39167.1 - 0.086 12.7 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Rx_N PF18052.1 EFE39167.1 - 0.16 12.3 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Rx N-terminal domain DSPc PF00782.20 EFE39168.1 - 2.3e-11 43.6 0.0 4.6e-11 42.7 0.0 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EFE39168.1 - 0.0001 22.6 0.0 0.0002 21.6 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Ribosomal_L5e PF17144.4 EFE39169.1 - 0.099 12.6 0.0 0.23 11.4 0.0 1.6 2 0 0 2 2 2 0 Ribosomal large subunit proteins 60S L5, and 50S L18 SNF2_N PF00176.23 EFE39170.1 - 4.8e-64 216.3 0.1 1.8e-63 214.4 0.1 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE39170.1 - 8.5e-22 77.6 0.2 9.1e-21 74.3 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE39170.1 - 9.2e-08 32.3 0.8 8.1e-07 29.2 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EFE39170.1 - 1.8e-05 24.1 1.9 0.0066 15.7 0.0 3.9 3 1 0 3 3 3 2 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 EFE39170.1 - 0.00014 21.2 0.0 0.00014 21.2 0.0 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Shugoshin_C PF07557.11 EFE39170.1 - 1 9.2 6.8 3.7 7.4 3.1 3.1 2 0 0 2 2 2 0 Shugoshin C terminus DDHD PF02862.17 EFE39170.1 - 3.1 7.9 11.3 13 5.9 5.2 2.7 2 0 0 2 2 2 0 DDHD domain End3 PF12761.7 EFE39171.1 - 1.1e-72 244.3 1.5 1.5e-72 243.9 1.5 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 EFE39171.1 - 2.4e-51 172.0 0.1 5e-49 164.6 0.0 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EFE39171.1 - 8.5e-08 31.2 0.2 2.6e-07 29.7 0.2 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EFE39171.1 - 1.2e-06 28.9 0.7 6.1e-06 26.6 0.1 2.5 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EFE39171.1 - 9.6e-05 22.0 0.5 0.00043 20.0 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EFE39171.1 - 0.0016 18.2 0.2 0.0053 16.6 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EFE39171.1 - 0.0029 17.0 1.0 0.0094 15.4 0.2 2.2 2 0 0 2 2 2 1 EF hand NPV_P10 PF05531.12 EFE39171.1 - 0.015 15.7 0.2 0.23 12.0 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SKA1 PF07160.12 EFE39171.1 - 0.029 14.2 0.3 0.058 13.2 0.3 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4407 PF14362.6 EFE39171.1 - 0.068 12.5 4.9 0.097 12.0 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COG2 PF06148.11 EFE39171.1 - 0.68 10.0 4.4 1.9 8.5 0.5 2.7 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.11 EFE39171.1 - 1.4 7.8 11.2 0.25 10.2 4.2 2.1 1 1 0 2 2 2 0 Spc7 kinetochore protein Wtap PF17098.5 EFE39171.1 - 1.6 8.6 9.3 1.5 8.8 7.5 1.7 2 0 0 2 2 2 0 WTAP/Mum2p family Sec2p PF06428.11 EFE39171.1 - 2.4 8.2 10.2 7.6 6.6 0.9 2.5 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Med9 PF07544.13 EFE39171.1 - 3.4 7.8 5.8 0.48 10.6 0.2 2.4 3 0 0 3 3 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4201 PF13870.6 EFE39171.1 - 4.2 7.1 9.0 0.99 9.1 4.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Pkinase PF00069.25 EFE39173.1 - 0.0002 20.8 0.0 0.00025 20.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain MFS_1 PF07690.16 EFE39175.1 - 1.3e-33 116.5 20.7 1.3e-33 116.5 20.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EFE39175.1 - 4.1e-07 29.6 0.5 4.1e-07 29.6 0.5 3.0 3 1 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB Yae1_N PF09811.9 EFE39176.1 - 2.5e-13 49.5 0.3 4.8e-13 48.6 0.3 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Romo1 PF10247.9 EFE39176.1 - 0.15 12.4 0.5 0.28 11.6 0.5 1.4 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 SCO1-SenC PF02630.14 EFE39178.1 - 4.2e-47 159.4 0.0 5.5e-47 159.0 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EFE39178.1 - 0.0012 18.7 0.0 0.0025 17.7 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EFE39178.1 - 0.049 14.0 0.0 0.11 12.8 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like MoaE PF02391.17 EFE39179.1 - 1.6e-36 125.0 0.1 2e-36 124.7 0.1 1.1 1 0 0 1 1 1 1 MoaE protein Ntox25 PF15530.6 EFE39179.1 - 0.15 12.2 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial toxin 25 SLAC1 PF03595.17 EFE39180.1 - 2.1e-59 201.4 30.1 2.3e-59 201.3 30.1 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Caerin_1 PF07440.12 EFE39180.1 - 0.14 12.2 2.3 9 6.5 1.1 2.5 2 0 0 2 2 2 0 Caerin 1 protein T4SS_CagC PF16943.5 EFE39180.1 - 0.62 10.3 6.2 0.36 11.0 0.3 2.4 2 0 0 2 2 2 0 Cag pathogenicity island, type IV secretory system SLAC1 PF03595.17 EFE39181.1 - 6.3e-34 117.7 19.2 7.3e-34 117.5 19.2 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel FAD_binding_3 PF01494.19 EFE39183.1 - 5.6e-13 48.9 0.0 1.7e-12 47.3 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFE39183.1 - 0.0001 22.4 0.0 0.00027 21.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE39183.1 - 0.00019 20.8 0.1 0.0067 15.7 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFE39183.1 - 0.0003 19.8 0.7 0.0004 19.4 0.1 1.5 2 0 0 2 2 2 1 Tryptophan halogenase DAO PF01266.24 EFE39183.1 - 0.0004 20.1 0.2 0.00063 19.4 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EFE39183.1 - 0.02 14.2 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF1967 PF09269.11 EFE39183.1 - 0.021 14.7 0.8 0.12 12.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1967) NAD_binding_9 PF13454.6 EFE39183.1 - 0.041 13.9 0.0 0.087 12.8 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.17 EFE39183.1 - 0.05 12.8 0.0 0.081 12.1 0.0 1.2 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 EFE39183.1 - 0.16 11.3 0.4 0.26 10.6 0.4 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EFE39183.1 - 0.19 10.8 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A MCRA PF06100.11 EFE39183.1 - 0.19 10.5 0.1 0.3 9.8 0.1 1.2 1 0 0 1 1 1 0 MCRA family EI24 PF07264.11 EFE39185.1 - 2.6e-12 47.3 4.8 3.9e-12 46.8 4.8 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) zf-RING_11 PF17123.5 EFE39186.1 - 2.1e-09 36.9 2.5 3.7e-09 36.2 2.5 1.4 1 0 0 1 1 1 1 RING-like zinc finger PA PF02225.22 EFE39186.1 - 8.3e-08 32.2 0.0 2.1e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-RING_2 PF13639.6 EFE39186.1 - 4.2e-07 30.2 0.9 7.3e-07 29.4 0.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFE39186.1 - 3.9e-05 23.6 0.3 7.9e-05 22.6 0.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFE39186.1 - 0.00012 21.9 1.0 0.00021 21.1 1.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE39186.1 - 0.00021 21.1 0.9 0.00035 20.4 0.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE39186.1 - 0.00036 20.4 0.3 0.00062 19.7 0.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EFE39186.1 - 0.022 15.0 0.5 0.052 13.8 0.5 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFE39186.1 - 0.22 11.4 1.3 0.35 10.8 1.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFE39186.1 - 0.32 11.2 0.7 0.77 10.0 0.7 1.6 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING SelK_SelG PF10961.8 EFE39186.1 - 4.2 8.0 0.0 4.2 8.0 0.0 4.8 5 1 0 5 5 4 0 Selenoprotein SelK_SelG Raptor_N PF14538.6 EFE39189.1 - 2.8e-65 218.7 0.0 5.1e-65 217.9 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 EFE39189.1 - 1.3e-05 25.8 3.0 0.41 11.6 0.1 5.1 4 0 0 4 4 4 1 WD domain, G-beta repeat HEAT PF02985.22 EFE39189.1 - 0.0015 18.6 0.7 0.5 10.8 0.0 3.5 2 0 0 2 2 2 1 HEAT repeat Peptidase_C14 PF00656.22 EFE39189.1 - 0.0028 17.7 0.0 0.0053 16.8 0.0 1.4 1 0 0 1 1 1 1 Caspase domain HEAT_2 PF13646.6 EFE39189.1 - 0.0035 17.7 0.0 0.012 16.0 0.0 1.9 1 0 0 1 1 1 1 HEAT repeats Atx10homo_assoc PF09759.9 EFE39189.1 - 0.026 14.5 0.0 0.061 13.4 0.0 1.6 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain BBS2_Mid PF14783.6 EFE39189.1 - 0.22 11.6 0.1 11 6.1 0.1 2.6 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DUF4396 PF14342.6 EFE39190.1 - 3.1e-41 141.1 3.3 5.8e-41 140.1 3.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) NiFe_hyd_3_EhaA PF17367.2 EFE39190.1 - 0.061 13.5 0.2 0.15 12.3 0.2 1.6 1 0 0 1 1 1 0 NiFe-hydrogenase-type-3 Eha complex subunit A Kelch_5 PF13854.6 EFE39191.1 - 1.9e-31 107.5 4.1 1.2e-06 28.4 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EFE39191.1 - 1.5e-22 79.4 21.8 1.5e-06 28.4 0.0 7.3 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_4 PF13418.6 EFE39191.1 - 8e-21 73.8 9.8 0.00033 20.6 0.1 6.9 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 EFE39191.1 - 3.3e-19 68.4 6.6 3.9e-05 23.8 0.3 6.7 4 1 2 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EFE39191.1 - 6.8e-19 67.2 7.0 1.5e-05 24.5 1.3 7.1 6 1 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EFE39191.1 - 3e-15 55.5 5.7 0.004 17.1 0.3 6.8 6 1 0 6 6 6 4 Kelch motif YabA PF06156.13 EFE39191.1 - 0.0081 16.8 2.4 0.0081 16.8 2.4 7.8 4 2 3 7 7 7 1 Initiation control protein YabA Pkinase PF00069.25 EFE39192.1 - 7.7e-26 91.0 0.0 9.8e-26 90.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39192.1 - 9.9e-14 51.2 0.0 1.3e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE39192.1 - 6.3e-09 35.1 0.0 8.8e-09 34.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFE39192.1 - 0.00031 20.7 0.0 0.002 18.1 0.0 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family bZIP_1 PF00170.21 EFE39194.1 - 8.4e-06 25.8 12.6 1.3e-05 25.2 12.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor SHE3 PF17078.5 EFE39194.1 - 2.7e-05 24.0 6.3 3.9e-05 23.5 6.3 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 V_ATPase_I PF01496.19 EFE39194.1 - 0.0026 15.8 0.9 0.0033 15.4 0.9 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family bZIP_Maf PF03131.17 EFE39194.1 - 0.019 15.5 10.7 0.032 14.8 10.7 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor CCDC106 PF15794.5 EFE39194.1 - 0.026 14.3 7.3 0.037 13.8 4.9 1.9 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 Tmemb_cc2 PF10267.9 EFE39194.1 - 0.036 13.2 3.2 0.054 12.6 3.2 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein GAS PF13851.6 EFE39194.1 - 0.057 12.8 6.5 0.082 12.3 6.5 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Pox_A_type_inc PF04508.12 EFE39194.1 - 0.07 13.0 1.7 0.18 11.7 1.7 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat DUF1043 PF06295.12 EFE39194.1 - 0.098 12.7 2.2 0.22 11.6 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) TMF_TATA_bd PF12325.8 EFE39194.1 - 0.13 12.5 4.5 0.23 11.7 4.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding PAP1 PF08601.10 EFE39194.1 - 0.21 11.3 0.1 0.21 11.3 0.1 2.3 2 0 0 2 2 2 0 Transcription factor PAP1 bZIP_2 PF07716.15 EFE39194.1 - 0.37 10.9 16.7 0.61 10.2 15.6 1.9 1 1 1 2 2 2 0 Basic region leucine zipper CDC45 PF02724.14 EFE39194.1 - 0.78 8.0 5.7 1 7.6 5.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Phosducin PF02114.16 EFE39195.1 - 1.8e-11 43.5 0.0 2.2e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Phosducin Flagellar_rod PF05149.12 EFE39195.1 - 0.00097 18.7 0.4 0.0015 18.0 0.4 1.2 1 0 0 1 1 1 1 Paraflagellar rod protein Adaptin_N PF01602.20 EFE39196.1 - 7.4e-112 374.6 0.5 1e-111 374.1 0.5 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EFE39196.1 - 8e-60 201.4 2.4 1.8e-59 200.2 2.4 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EFE39196.1 - 5.3e-32 110.4 0.2 2.8e-31 108.0 0.0 2.3 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EFE39196.1 - 1.3e-18 67.2 2.1 1.4e-12 47.8 0.0 4.9 4 1 1 5 5 5 2 HEAT repeats Cnd1 PF12717.7 EFE39196.1 - 3.2e-07 30.5 12.2 0.0016 18.5 0.1 5.5 5 1 1 6 6 6 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFE39196.1 - 0.00012 22.1 5.5 0.43 11.0 0.3 5.9 6 0 0 6 6 6 1 HEAT repeat Alpha_adaptin_C PF02296.16 EFE39196.1 - 0.0022 18.2 0.0 0.0081 16.3 0.0 2.0 2 0 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain HEAT_PBS PF03130.16 EFE39196.1 - 0.04 14.6 5.9 2.4 9.1 0.1 4.8 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 EFE39196.1 - 0.21 12.1 3.4 0.23 12.0 0.4 2.7 3 0 0 3 3 3 0 HEAT-like repeat F-box-like PF12937.7 EFE39197.1 - 9.7e-11 41.4 1.4 2.4e-10 40.1 0.4 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFE39197.1 - 0.087 12.7 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 F-box domain Hydrolase_like PF13242.6 EFE39198.1 - 9e-16 57.7 0.0 5.7e-15 55.1 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EFE39198.1 - 3.6e-07 30.2 0.0 7.5e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase tRNA-synt_2 PF00152.20 EFE39199.1 - 3.1e-66 223.6 0.1 4.1e-66 223.2 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFE39199.1 - 2.2e-06 27.5 0.0 4.3e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain SIP1 PF04938.12 EFE39200.1 - 2.4e-10 40.5 0.3 4.1e-08 33.2 0.0 2.6 2 2 0 2 2 2 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) PX PF00787.24 EFE39201.1 - 1.4e-16 60.5 0.1 3.5e-16 59.2 0.0 1.6 2 0 0 2 2 2 1 PX domain Ku_PK_bind PF08785.11 EFE39202.1 - 1.8e-35 121.7 0.3 4.3e-35 120.5 0.3 1.6 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.16 EFE39202.1 - 9.7e-23 80.9 0.0 1.9e-22 80.0 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain VWA PF00092.28 EFE39202.1 - 0.0056 17.0 0.0 0.017 15.4 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain Ku_N PF03731.15 EFE39202.1 - 0.022 14.5 0.0 0.047 13.4 0.0 1.6 1 0 0 1 1 1 0 Ku70/Ku80 N-terminal alpha/beta domain DUF4149 PF13664.6 EFE39203.1 - 2.9e-17 62.9 0.5 8.6e-17 61.3 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF1772 PF08592.11 EFE39203.1 - 0.023 15.0 0.0 0.027 14.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Baculo_PEP_C PF04513.12 EFE39204.1 - 0.0099 15.9 16.4 5.1 7.1 1.8 5.9 1 1 5 6 6 6 2 Baculovirus polyhedron envelope protein, PEP, C terminus ROS_MUCR PF05443.11 EFE39204.1 - 0.028 14.5 12.2 0.037 14.1 1.4 4.0 3 1 1 4 4 4 0 ROS/MUCR transcriptional regulator protein Cnn_1N PF07989.11 EFE39204.1 - 0.085 13.0 0.3 0.085 13.0 0.3 5.8 4 1 0 5 5 5 0 Centrosomin N-terminal motif 1 DUF3146 PF11344.8 EFE39204.1 - 0.18 11.5 0.0 0.39 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3146) DUF730 PF05325.11 EFE39204.1 - 0.28 11.2 0.1 0.28 11.2 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF730) DCB PF16213.5 EFE39204.1 - 7.2 6.2 15.3 2.4 7.8 2.0 3.8 3 1 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 DUF2408 PF10303.9 EFE39204.1 - 7.3 7.2 29.5 0.51 10.9 6.5 4.8 1 1 3 4 4 4 0 Protein of unknown function (DUF2408) Topoisom_bac PF01131.20 EFE39205.1 - 1.3e-82 278.0 0.0 6.3e-82 275.8 0.0 1.9 1 1 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EFE39205.1 - 7e-14 51.9 0.0 2.1e-13 50.4 0.0 1.9 2 0 0 2 2 2 1 Toprim domain DUF1295 PF06966.12 EFE39206.1 - 2.4e-40 138.6 6.7 3.7e-40 137.9 6.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 EFE39206.1 - 0.043 14.2 0.1 0.27 11.7 0.0 2.3 1 1 1 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Peptidase_M41 PF01434.18 EFE39207.1 - 5.1e-67 225.4 1.8 6.3e-67 225.1 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 EFE39207.1 - 8.5e-42 142.7 0.0 2.5e-41 141.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE39207.1 - 8.1e-12 44.8 0.1 2.4e-11 43.2 0.1 1.9 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EFE39207.1 - 6.3e-09 36.2 1.0 1.6e-08 34.8 0.0 2.3 2 0 0 2 2 2 1 FtsH Extracellular AAA_5 PF07728.14 EFE39207.1 - 0.003 17.6 0.0 0.014 15.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFE39207.1 - 0.0033 17.8 0.2 0.16 12.4 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EFE39207.1 - 0.0085 16.4 0.2 1.2 9.4 0.0 3.4 4 0 0 4 4 4 1 AAA domain RuvB_N PF05496.12 EFE39207.1 - 0.021 14.5 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EFE39207.1 - 0.022 14.0 0.0 0.048 12.9 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 EFE39207.1 - 0.03 14.1 0.0 0.071 12.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 EFE39207.1 - 1.1 9.7 5.6 2.4 8.6 0.0 3.5 3 1 0 3 3 3 0 AAA domain Fungal_trans PF04082.18 EFE39208.1 - 6.8e-18 64.6 0.0 6.8e-18 64.6 0.0 3.2 4 1 0 4 4 4 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE39208.1 - 2.2e-09 37.3 13.3 2.2e-09 37.3 13.3 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4834 PF16118.5 EFE39208.1 - 0.018 16.0 1.5 0.018 16.0 1.5 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 EFE39208.1 - 0.22 11.5 26.9 0.6 10.1 19.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit TERB2 PF15101.6 EFE39208.1 - 0.31 11.0 8.6 0.67 10.0 8.6 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Ctr PF04145.15 EFE39208.1 - 0.33 11.6 4.4 0.21 12.2 0.7 2.3 2 0 0 2 2 2 0 Ctr copper transporter family F-112 PF09645.10 EFE39208.1 - 0.79 9.9 10.4 3.1 8.0 10.4 2.0 1 0 0 1 1 1 0 F-112 protein NUDE_C PF04880.13 EFE39208.1 - 1.7 9.1 21.7 0.65 10.5 10.7 2.4 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Ndc1_Nup PF09531.10 EFE39208.1 - 3.8 6.1 20.4 3.6 6.2 0.8 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 EFE39208.1 - 7.8 4.9 18.7 0.93 8.0 10.1 2.2 2 0 0 2 2 2 0 Macoilin family APH PF01636.23 EFE39209.1 - 2e-08 34.5 0.0 1.4e-07 31.7 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family tRNA-synt_2b PF00587.25 EFE39210.1 - 2.3e-30 105.9 0.0 1.1e-28 100.5 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFE39210.1 - 7e-16 58.2 0.1 1.3e-15 57.3 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 EFE39210.1 - 5.2e-13 48.9 0.0 9.5e-13 48.0 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EFE39210.1 - 0.0025 17.8 0.0 0.0072 16.3 0.0 1.7 1 0 0 1 1 1 1 TGS domain Gar1 PF04410.14 EFE39211.1 - 1.4e-37 128.9 0.0 1.6e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region CDP-OH_P_transf PF01066.21 EFE39212.1 - 2.1e-11 44.4 0.4 6.2e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase WSC PF01822.19 EFE39213.1 - 3.6e-08 33.5 8.6 7.4e-08 32.5 8.6 1.6 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.10 EFE39213.1 - 2.4e-06 26.9 3.3 5.4e-06 25.7 3.3 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain LapA_dom PF06305.11 EFE39213.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain MGC-24 PF05283.11 EFE39213.1 - 0.14 12.6 2.5 0.16 12.4 0.4 2.1 1 1 1 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin PAT1 PF09770.9 EFE39214.1 - 0.05 11.9 7.1 0.083 11.2 7.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2370 PF10176.9 EFE39215.1 - 2.2e-90 302.3 0.0 4.2e-90 301.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) MLANA PF14991.6 EFE39215.1 - 0.044 14.1 0.1 6.4 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein melan-A CoA_trans PF01144.23 EFE39216.1 - 3.3e-104 347.0 1.8 1.2e-64 217.6 0.4 2.0 2 0 0 2 2 2 2 Coenzyme A transferase MFS_1 PF07690.16 EFE39217.1 - 2e-19 69.7 58.1 2.8e-17 62.7 31.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UCH PF00443.29 EFE39218.1 - 4.1e-45 154.3 0.5 3.6e-44 151.2 0.6 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 EFE39218.1 - 7.1e-44 147.6 4.0 5.1e-18 64.7 0.0 4.7 4 0 0 4 4 4 3 A repeated domain in UCH-protein UCH_1 PF13423.6 EFE39218.1 - 0.0009 18.9 5.1 0.0061 16.2 5.1 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Microvir_H PF04687.12 EFE39218.1 - 0.0092 15.4 0.7 0.015 14.7 0.7 1.2 1 0 0 1 1 1 1 Microvirus H protein (pilot protein) YAF2_RYBP PF17219.3 EFE39219.1 - 0.098 12.3 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Yaf2/RYBP C-terminal binding motif PUB PF09409.10 EFE39219.1 - 0.12 12.3 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 PUB domain Tim17 PF02466.19 EFE39220.1 - 2e-08 34.5 3.1 3.7e-08 33.7 3.1 1.5 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family PH PF00169.29 EFE39221.1 - 0.0015 19.0 0.0 0.0035 17.8 0.0 1.7 1 0 0 1 1 1 1 PH domain DUF5344 PF17279.2 EFE39221.1 - 0.075 13.6 0.5 2.5 8.8 0.1 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5344) CHAD PF05235.14 EFE39221.1 - 0.74 9.7 5.0 0.63 10.0 0.1 2.6 3 0 0 3 3 3 0 CHAD domain RRM_1 PF00076.22 EFE39222.1 - 3.2e-30 103.7 0.0 1.1e-17 63.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATP-grasp_2 PF08442.10 EFE39222.1 - 0.0049 16.5 0.0 0.16 11.5 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain RRM_3 PF08777.11 EFE39222.1 - 0.018 15.1 0.0 0.88 9.7 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif PknH_C PF14032.6 EFE39222.1 - 0.02 14.7 0.4 7.2 6.4 0.1 2.2 2 0 0 2 2 2 0 PknH-like extracellular domain RRM_occluded PF16842.5 EFE39222.1 - 0.11 12.3 0.0 13 5.7 0.0 2.8 2 1 1 3 3 3 0 Occluded RNA-recognition motif FmdA_AmdA PF03069.15 EFE39223.1 - 9.3e-59 199.1 0.0 3.5e-34 118.3 0.0 2.0 1 1 1 2 2 2 2 Acetamidase/Formamidase family AA_permease_2 PF13520.6 EFE39224.1 - 7.1e-55 186.5 44.9 9.3e-55 186.2 44.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE39224.1 - 1.6e-20 73.2 41.2 2.1e-20 72.8 41.2 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3043 PF11241.8 EFE39224.1 - 1.2 9.1 5.8 4.8 7.2 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3043) COQ9 PF08511.11 EFE39225.1 - 5.5e-26 90.1 0.6 1.2e-25 89.0 0.1 1.8 2 0 0 2 2 2 1 COQ9 UvrA_inter PF17760.1 EFE39226.1 - 0.027 14.5 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 UvrA interaction domain WD40 PF00400.32 EFE39227.1 - 9.3e-05 23.1 0.1 2.5 9.1 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat DNA_methylase PF00145.17 EFE39228.1 - 7e-33 114.4 0.0 1.2e-32 113.6 0.0 1.4 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.18 EFE39228.1 - 3.8e-06 26.8 0.1 0.0017 18.2 0.1 2.5 2 0 0 2 2 2 2 BAH domain RasGAP PF00616.19 EFE39229.1 - 9.2e-27 94.1 0.0 3.4e-15 56.3 0.0 3.4 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EFE39229.1 - 8.4e-08 32.4 0.0 6.1e-07 29.7 0.0 2.5 2 1 0 2 2 2 1 C2 domain DUF872 PF05915.12 EFE39230.1 - 0.062 13.5 1.3 1.5 9.0 0.1 2.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Methyltransf_2 PF00891.18 EFE39231.1 - 1.2e-23 83.5 0.0 3.8e-23 81.9 0.0 1.7 1 1 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFE39231.1 - 0.0066 16.4 0.1 0.013 15.5 0.1 1.5 1 0 0 1 1 1 1 Dimerisation domain HTH_47 PF16221.5 EFE39231.1 - 0.028 14.0 0.1 0.22 11.1 0.0 2.2 2 0 0 2 2 2 0 winged helix-turn-helix Rrf2 PF02082.20 EFE39231.1 - 0.13 12.7 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator PDZ_3 PF17815.1 EFE39231.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 PDZ domain GFO_IDH_MocA PF01408.22 EFE39232.1 - 4.4e-15 56.5 0.0 6.7e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EFE39232.1 - 2.1e-05 24.5 0.0 0.00011 22.2 0.0 2.2 2 1 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EFE39232.1 - 0.023 15.4 0.1 0.043 14.5 0.1 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain ADSL_C PF10397.9 EFE39232.1 - 0.11 13.1 0.3 9 6.9 0.0 2.3 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminus Transp_cyt_pur PF02133.15 EFE39233.1 - 5.8e-86 289.0 29.7 7e-86 288.7 29.7 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin AMP-binding PF00501.28 EFE39234.1 - 2.2e-57 194.6 0.1 1.7e-39 135.6 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EFE39234.1 - 6.3e-23 81.2 0.0 2.2e-22 79.4 0.0 1.8 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EFE39234.1 - 5.9e-08 33.0 0.1 1.5e-07 31.6 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site ESX-1_EspG PF14011.6 EFE39234.1 - 0.077 12.6 0.8 0.26 10.9 0.8 1.8 1 0 0 1 1 1 0 EspG family WES_acyltransf PF03007.16 EFE39234.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Condensation PF00668.20 EFE39235.1 - 5.3e-15 55.1 0.0 6.2e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 Condensation domain Peptidase_M19 PF01244.21 EFE39236.1 - 7.5e-103 344.0 0.0 8.7e-103 343.8 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) p450 PF00067.22 EFE39237.1 - 2.3e-43 148.6 0.0 2.9e-42 145.0 0.0 1.9 2 0 0 2 2 2 1 Cytochrome P450 AIMP2_LysRS_bd PF16780.5 EFE39237.1 - 0.08 12.7 0.0 17 5.3 0.0 2.5 2 0 0 2 2 2 0 AIMP2 lysyl-tRNA synthetase binding domain GST_C PF00043.25 EFE39238.1 - 3e-07 30.5 0.0 4.7e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFE39238.1 - 3.4e-06 27.2 0.0 6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFE39238.1 - 7.1e-05 23.0 0.0 0.00014 22.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFE39238.1 - 7.2e-05 23.1 0.0 0.00013 22.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFE39238.1 - 0.00061 19.8 0.1 0.0011 19.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFE39238.1 - 0.0035 17.6 0.0 0.0065 16.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Methyltransf_2 PF00891.18 EFE39239.1 - 3.3e-30 105.0 0.0 9.2e-30 103.5 0.0 1.8 1 1 1 2 2 2 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFE39239.1 - 3.3e-05 23.8 0.0 6.3e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain Dimerisation PF08100.11 EFE39239.1 - 0.00016 21.6 0.5 0.00052 20.0 0.2 2.1 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_12 PF08242.12 EFE39239.1 - 0.031 15.0 0.0 0.1 13.4 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Rrf2 PF02082.20 EFE39239.1 - 0.057 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator Methyltransf_25 PF13649.6 EFE39239.1 - 0.14 12.9 0.0 0.74 10.6 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain Pyr_redox_2 PF07992.14 EFE39240.1 - 1.6e-16 60.4 0.0 2.5e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFE39240.1 - 6.1e-05 22.3 0.2 0.00022 20.4 0.1 1.9 2 1 1 3 3 3 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EFE39240.1 - 8.3e-05 22.6 0.0 0.82 9.7 0.0 3.2 2 1 1 3 3 3 2 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EFE39240.1 - 0.00015 20.7 0.0 0.00076 18.4 0.0 1.9 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.6 EFE39240.1 - 0.00019 21.6 0.4 0.00057 20.1 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFE39240.1 - 0.0006 18.6 0.0 0.0024 16.6 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EFE39240.1 - 0.0011 18.7 0.3 0.0044 16.7 0.2 2.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFE39240.1 - 0.0016 17.6 0.0 0.0035 16.5 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EFE39240.1 - 0.003 16.8 0.0 0.0071 15.6 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFE39240.1 - 0.0039 16.3 0.0 0.22 10.5 0.0 2.9 3 0 0 3 3 3 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 EFE39240.1 - 0.0087 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EFE39240.1 - 0.034 13.4 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 EFE39240.1 - 0.046 13.0 0.6 0.082 12.2 0.0 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EFE39240.1 - 0.064 12.6 1.2 0.1 11.9 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase UvrB_inter PF17757.1 EFE39242.1 - 0.033 14.3 0.0 0.071 13.3 0.0 1.5 1 0 0 1 1 1 0 UvrB interaction domain Pyr_redox_2 PF07992.14 EFE39243.1 - 3.4e-17 62.6 0.0 7.6e-16 58.2 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFE39243.1 - 0.0002 21.0 0.3 0.0068 16.0 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFE39243.1 - 0.00083 18.5 0.3 0.0023 17.1 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EFE39243.1 - 0.0015 18.7 0.5 0.003 17.7 0.5 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFE39243.1 - 0.0024 17.9 0.5 1.2 9.1 0.3 3.5 2 2 2 4 4 4 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EFE39243.1 - 0.021 14.1 0.7 2.1 7.5 0.2 3.0 2 2 2 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFE39243.1 - 0.039 13.0 0.0 0.082 12.0 0.0 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EFE39243.1 - 0.044 13.1 0.0 0.094 12.0 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EFE39243.1 - 0.049 12.3 0.2 0.17 10.6 0.1 1.9 2 0 0 2 2 2 0 HI0933-like protein p450 PF00067.22 EFE39244.1 - 7.3e-34 117.3 0.0 1e-33 116.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Aminotran_1_2 PF00155.21 EFE39245.1 - 1.8e-36 126.1 0.0 2.4e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II MBOAT_2 PF13813.6 EFE39245.1 - 1.1e-12 48.0 0.4 2.4e-12 46.9 0.4 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family ABC_tran PF00005.27 EFE39246.1 - 3.6e-32 111.7 0.0 7e-32 110.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EFE39246.1 - 4.8e-17 62.5 21.9 9.9e-15 54.9 10.1 2.3 1 1 1 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EFE39246.1 - 2e-07 30.7 0.0 0.00036 20.0 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFE39246.1 - 0.00076 19.2 0.1 0.0019 17.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFE39246.1 - 0.00095 19.5 0.0 0.0041 17.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFE39246.1 - 0.0015 19.0 0.2 0.0083 16.5 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 EFE39246.1 - 0.008 16.4 0.3 0.23 11.7 0.3 2.6 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 EFE39246.1 - 0.011 15.5 0.0 0.029 14.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFE39246.1 - 0.012 16.2 0.0 0.024 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFE39246.1 - 0.03 14.2 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_10 PF12846.7 EFE39246.1 - 0.034 13.1 0.0 0.049 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_30 PF13604.6 EFE39246.1 - 0.041 13.6 0.1 0.087 12.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EFE39246.1 - 0.053 13.2 0.0 0.085 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EFE39246.1 - 0.056 13.2 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 EFE39246.1 - 0.072 13.2 0.5 0.17 11.9 0.1 1.7 2 0 0 2 2 2 0 Helicase HerA, central domain TmoB PF06234.12 EFE39246.1 - 0.074 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Toluene-4-monooxygenase system protein B (TmoB) Zeta_toxin PF06414.12 EFE39246.1 - 0.094 12.0 0.1 0.25 10.6 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 EFE39246.1 - 0.15 12.4 0.0 1.3 9.5 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MFS_1 PF07690.16 EFE39247.1 - 1.7e-44 152.2 47.2 1.7e-44 152.2 47.2 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE39247.1 - 5.8e-19 68.0 14.8 1.2e-18 66.9 14.8 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFE39247.1 - 9.3e-12 44.5 10.7 9.3e-12 44.5 10.7 3.1 1 1 2 3 3 3 1 Sugar (and other) transporter DUF1422 PF07226.11 EFE39247.1 - 0.011 15.7 0.4 0.011 15.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) PsbY PF06298.11 EFE39247.1 - 0.022 14.6 0.3 0.022 14.6 0.3 1.9 2 0 0 2 2 2 0 Photosystem II protein Y (PsbY) p450 PF00067.22 EFE39250.1 - 1.3e-57 195.6 0.0 2.7e-57 194.5 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 MOR2-PAG1_N PF14222.6 EFE39250.1 - 0.046 12.7 0.1 0.061 12.3 0.1 1.1 1 0 0 1 1 1 0 Cell morphogenesis N-terminal p450 PF00067.22 EFE39251.1 - 2e-18 66.4 0.0 2.7e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Trp_halogenase PF04820.14 EFE39252.1 - 1.5e-12 47.2 0.4 6.2e-12 45.1 0.3 1.9 1 1 0 1 1 1 1 Tryptophan halogenase MIEAP PF16026.5 EFE39252.1 - 0.15 12.3 0.2 0.23 11.6 0.2 1.3 1 0 0 1 1 1 0 Mitochondria-eating protein UNC45-central PF11701.8 EFE39253.1 - 1.4e-45 155.0 3.9 6.1e-45 152.9 1.2 3.0 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central Atx10homo_assoc PF09759.9 EFE39253.1 - 0.00085 19.3 0.0 1.5 8.9 0.0 2.9 2 0 0 2 2 2 2 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 EFE39253.1 - 0.014 15.4 12.2 28 4.9 0.1 7.4 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat Peptidase_S9 PF00326.21 EFE39253.1 - 0.21 11.0 0.0 0.5 9.8 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family Tfb4 PF03850.14 EFE39254.1 - 2.9e-109 364.8 0.0 3.8e-109 364.4 0.0 1.2 1 0 0 1 1 1 1 Transcription factor Tfb4 Asparaginase_2 PF01112.18 EFE39255.1 - 8.6e-46 156.4 5.0 3.1e-30 105.3 0.0 2.2 2 0 0 2 2 2 2 Asparaginase SasG_E PF17041.5 EFE39255.1 - 0.0057 16.6 0.2 0.015 15.3 0.2 1.7 1 0 0 1 1 1 1 E domain PEHE PF15275.6 EFE39255.1 - 0.1 13.3 0.1 0.25 12.0 0.1 1.6 1 0 0 1 1 1 0 PEHE domain Actin PF00022.19 EFE39257.1 - 1.2e-81 274.4 0.0 1.3e-79 267.7 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFE39257.1 - 0.00013 20.9 0.1 0.0044 15.9 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EFE39257.1 - 0.0051 17.2 0.0 0.0075 16.7 0.0 1.4 1 0 0 1 1 1 1 Cell division protein FtsA tRNA_U5-meth_tr PF05958.11 EFE39258.1 - 3e-16 59.4 0.1 3.6e-14 52.5 0.0 2.8 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EFE39258.1 - 6.8e-05 22.7 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE39258.1 - 9.1e-05 23.1 0.0 0.00028 21.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EFE39258.1 - 0.00028 20.5 0.0 0.00057 19.5 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 EFE39258.1 - 0.0025 18.4 0.0 0.019 15.6 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 EFE39258.1 - 0.027 13.9 0.0 0.06 12.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ribosomal_S5 PF00333.20 EFE39260.1 - 6.5e-21 74.1 0.2 1.4e-20 73.0 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EFE39260.1 - 4.4e-19 67.7 0.0 1.5e-18 66.0 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain EndIII_4Fe-2S PF10576.9 EFE39260.1 - 0.34 11.3 1.1 0.8 10.1 1.1 1.7 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III DASH_Dad3 PF08656.10 EFE39261.1 - 1.7e-29 101.7 2.1 2e-29 101.5 2.1 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 Peptidase_M75 PF09375.10 EFE39261.1 - 0.058 12.9 0.1 0.06 12.8 0.1 1.1 1 0 0 1 1 1 0 Imelysin Pkinase PF00069.25 EFE39263.1 - 1.2e-66 224.8 0.0 1.2e-37 129.8 0.2 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39263.1 - 6.2e-25 88.0 0.0 3.2e-15 56.1 0.1 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EFE39263.1 - 0.0025 17.2 0.1 0.74 9.1 0.0 2.4 2 0 0 2 2 2 2 Kinase-like DUF4267 PF14087.6 EFE39264.1 - 1.8e-26 92.4 5.2 2.2e-26 92.1 5.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) MFS_1 PF07690.16 EFE39265.1 - 1.6e-29 103.0 54.0 6.3e-26 91.1 55.5 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily UL41A PF17591.2 EFE39265.1 - 0.0046 17.0 0.8 0.0046 17.0 0.8 2.3 2 0 0 2 2 2 1 Herpesvirus UL41A PepSY_TM_like_2 PF16357.5 EFE39265.1 - 0.059 13.3 0.4 0.15 12.0 0.4 1.6 1 0 0 1 1 1 0 Putative PepSY_TM-like UEV PF05743.13 EFE39265.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 UEV domain DUF4006 PF13179.6 EFE39265.1 - 0.076 12.9 0.1 0.44 10.5 0.1 2.4 1 0 0 1 1 1 0 Family of unknown function (DUF4006) TRF PF08558.10 EFE39268.1 - 3.9e-81 272.2 0.3 7.2e-81 271.3 0.3 1.4 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EFE39268.1 - 0.0005 20.2 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain TFIID_30kDa PF03540.13 EFE39269.1 - 3.5e-22 78.1 0.1 6e-22 77.3 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit FoP_duplication PF13865.6 EFE39269.1 - 5.5 7.6 6.5 31 5.2 6.5 2.3 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 IPK PF03770.16 EFE39270.1 - 5.2e-60 202.7 0.0 6.5e-60 202.4 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase DNA_pol_phi PF04931.13 EFE39270.1 - 0.17 9.9 2.9 0.24 9.5 2.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi Arb1 PF09692.10 EFE39271.1 - 1.7e-140 468.7 0.3 2.1e-140 468.4 0.3 1.1 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 PG_binding_1 PF01471.18 EFE39271.1 - 0.15 12.3 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative peptidoglycan binding domain ADH_zinc_N PF00107.26 EFE39272.1 - 1.3e-25 89.8 0.0 2.5e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFE39272.1 - 3e-18 67.2 0.0 5.5e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE39272.1 - 1.1e-06 28.5 0.0 2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EFE39272.1 - 0.035 14.0 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase DUF3425 PF11905.8 EFE39273.1 - 1.5e-10 41.1 2.1 8.3e-09 35.5 0.3 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EFE39273.1 - 0.067 13.3 9.1 0.11 12.6 9.1 1.3 1 0 0 1 1 1 0 bZIP transcription factor Roughex PF06020.11 EFE39273.1 - 0.39 9.8 3.0 0.54 9.3 3.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Abhydrolase_1 PF00561.20 EFE39274.1 - 2.5e-14 53.6 0.0 3.8e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE39274.1 - 3.6e-11 44.1 0.0 5e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFE39274.1 - 6.3e-08 32.2 0.0 2.7e-07 30.1 0.0 1.9 2 1 0 2 2 2 1 Serine aminopeptidase, S33 DUF1989 PF09347.10 EFE39275.1 - 2e-65 219.5 0.1 2.5e-65 219.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) Aminotran_1_2 PF00155.21 EFE39277.1 - 2.4e-37 128.9 0.0 3.2e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II RIBIOP_C PF04950.12 EFE39278.1 - 1e-95 320.6 0.0 1e-95 320.6 0.0 1.9 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EFE39278.1 - 9.3e-29 99.4 0.0 2.4e-28 98.0 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 EFE39278.1 - 3.2e-05 23.5 0.0 0.0069 16.0 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EFE39278.1 - 7.2e-05 23.1 0.2 0.00021 21.6 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA PF00004.29 EFE39278.1 - 0.00012 22.5 0.0 0.00029 21.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFE39278.1 - 0.0002 21.8 0.0 0.00062 20.2 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EFE39278.1 - 0.00066 19.7 0.1 0.0022 18.0 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EFE39278.1 - 0.00083 19.9 0.5 0.025 15.1 0.1 3.2 2 0 0 2 2 2 1 AAA domain KCNQC3-Ank-G_bd PF11956.8 EFE39278.1 - 0.001 19.3 0.5 0.001 19.3 0.5 2.0 2 0 0 2 2 1 1 Ankyrin-G binding motif of KCNQ2-3 NB-ARC PF00931.22 EFE39278.1 - 0.0024 17.1 0.0 0.0057 15.9 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 EFE39278.1 - 0.0053 17.3 1.5 0.01 16.4 0.1 2.2 2 0 0 2 2 1 1 ABC transporter AAA_7 PF12775.7 EFE39278.1 - 0.0059 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region PduV-EutP PF10662.9 EFE39278.1 - 0.0088 15.8 0.0 0.091 12.5 0.0 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 EFE39278.1 - 0.011 16.1 0.0 0.027 14.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase cobW PF02492.19 EFE39278.1 - 0.017 14.8 0.1 0.034 13.7 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EFE39278.1 - 0.023 14.6 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 EFE39278.1 - 0.028 14.3 0.3 0.055 13.4 0.3 1.4 1 0 0 1 1 1 0 NTPase AAA_33 PF13671.6 EFE39278.1 - 0.031 14.5 0.0 0.031 14.5 0.0 2.3 2 0 0 2 2 1 0 AAA domain ATPase_2 PF01637.18 EFE39278.1 - 0.033 14.1 0.6 0.086 12.7 0.0 1.9 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EFE39278.1 - 0.035 14.5 0.1 0.081 13.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 EFE39278.1 - 0.042 13.3 0.0 0.089 12.2 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EFE39278.1 - 0.047 13.6 0.1 0.17 11.8 0.1 1.8 1 1 1 2 2 2 0 RsgA GTPase AAA_14 PF13173.6 EFE39278.1 - 0.053 13.6 0.1 0.14 12.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 EFE39278.1 - 0.057 13.6 0.1 0.18 12.0 0.1 1.9 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 EFE39278.1 - 0.06 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 EFE39278.1 - 0.062 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain AAA_5 PF07728.14 EFE39278.1 - 0.07 13.1 0.1 0.24 11.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 EFE39278.1 - 0.072 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain MobB PF03205.14 EFE39278.1 - 0.076 12.9 0.0 0.38 10.6 0.1 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.18 EFE39278.1 - 0.13 12.0 0.1 0.24 11.1 0.1 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATP_bind_1 PF03029.17 EFE39278.1 - 0.15 11.8 0.1 0.26 11.0 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_11 PF13086.6 EFE39278.1 - 0.16 11.8 0.0 0.16 11.8 0.0 3.1 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 EFE39278.1 - 0.18 11.5 0.0 0.37 10.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF1974 PF09317.11 EFE39280.1 - 0.081 12.5 0.4 0.15 11.6 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) CDPS PF16715.5 EFE39280.1 - 0.094 12.4 0.8 0.42 10.2 0.5 2.1 1 1 1 2 2 2 0 Cyclodipeptide synthase Na_H_Exchanger PF00999.21 EFE39281.1 - 7.4e-48 163.2 19.9 9.6e-48 162.9 19.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family 7TM_GPCR_Srv PF10323.9 EFE39281.1 - 0.061 12.7 1.0 0.17 11.2 0.8 1.7 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv GFO_IDH_MocA PF01408.22 EFE39282.1 - 1.6e-15 58.0 0.0 2.6e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Methyltransf_23 PF13489.6 EFE39283.1 - 1.2e-06 28.5 0.0 1.8e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0146 PF03686.13 EFE39283.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Methyltransf_31 PF13847.6 EFE39283.1 - 0.14 12.0 0.0 0.25 11.1 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain ERG4_ERG24 PF01222.17 EFE39284.1 - 1.7e-138 462.0 20.3 2e-138 461.8 20.3 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family zf-C3HC4 PF00097.25 EFE39286.1 - 1.1e-05 25.2 9.4 2.1e-05 24.3 9.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE39286.1 - 2.7e-05 24.1 5.2 2.7e-05 24.1 5.2 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFE39286.1 - 0.00018 21.8 11.6 0.0031 17.8 5.7 2.3 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.6 EFE39286.1 - 0.00048 20.0 6.7 0.0011 18.9 6.6 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFE39286.1 - 0.00094 19.0 7.7 0.0021 17.9 7.7 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFE39286.1 - 0.0022 17.8 6.2 0.0022 17.8 6.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFE39286.1 - 0.0029 17.7 8.8 0.015 15.5 8.9 2.0 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING GAGA PF09237.11 EFE39286.1 - 0.41 10.5 2.8 0.44 10.4 0.3 2.3 2 0 0 2 2 2 0 GAGA factor UCH PF00443.29 EFE39287.1 - 9.9e-38 130.1 0.0 8.7e-37 127.0 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE39287.1 - 2.4e-10 40.5 0.0 6e-10 39.2 0.0 1.6 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DLH PF01738.18 EFE39288.1 - 6.6e-23 81.4 0.0 8.9e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EFE39288.1 - 0.0045 16.9 0.0 0.11 12.4 0.0 2.2 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 EFE39288.1 - 0.023 14.3 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Chs7 PF12271.8 EFE39289.1 - 1.6e-74 250.9 12.8 1.8e-74 250.7 12.8 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone MpPF26 PF07666.11 EFE39289.1 - 0.012 15.8 3.5 0.012 15.8 3.5 3.0 2 2 1 3 3 3 0 M penetrans paralogue family 26 DUF2569 PF10754.9 EFE39289.1 - 0.19 12.1 14.1 0.019 15.4 8.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) UPF0220 PF05255.11 EFE39289.1 - 0.34 10.4 6.3 0.15 11.6 0.8 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0220) EMP70 PF02990.16 EFE39289.1 - 0.83 8.2 9.1 1 7.9 9.1 1.2 1 0 0 1 1 1 0 Endomembrane protein 70 TssN PF17555.2 EFE39289.1 - 5.8 6.2 12.2 0.3 10.5 3.6 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssN Glyoxalase PF00903.25 EFE39290.1 - 4.1e-05 23.8 0.1 0.00014 22.1 0.1 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAP17 PF15807.5 EFE39291.1 - 4.1 7.7 4.9 5.1 7.4 4.9 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Ge1_WD40 PF16529.5 EFE39292.1 - 0.0079 15.2 0.0 0.019 14.0 0.0 1.6 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Importin_rep_6 PF18829.1 EFE39292.1 - 0.11 12.7 0.7 0.32 11.1 0.1 2.0 2 0 0 2 2 2 0 Importin repeat 6 DUF4239 PF14023.6 EFE39292.1 - 0.39 10.4 1.7 1 9.1 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) EMP24_GP25L PF01105.24 EFE39292.1 - 2.4 8.1 4.4 40 4.1 1.2 3.0 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD dCMP_cyt_deam_1 PF00383.23 EFE39293.1 - 6.8e-05 22.7 0.0 0.00037 20.3 0.0 2.1 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region DUF4819 PF16090.5 EFE39293.1 - 0.035 14.2 0.1 0.23 11.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4819) Cyclin PF08613.11 EFE39294.1 - 6.8e-29 101.3 5.3 6.8e-29 101.3 5.3 3.8 4 1 0 4 4 4 1 Cyclin Cyclin_N PF00134.23 EFE39294.1 - 0.00053 19.7 0.0 0.00053 19.7 0.0 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIA PF03153.13 EFE39294.1 - 3.1 7.7 51.2 0.024 14.7 41.2 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit FAM76 PF16046.5 EFE39294.1 - 8.6 5.6 18.4 0.56 9.5 6.8 2.3 2 0 0 2 2 2 0 FAM76 protein Arm PF00514.23 EFE39295.1 - 9.5e-13 47.7 11.5 0.009 16.0 0.5 8.7 9 0 0 9 9 9 5 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EFE39295.1 - 0.076 13.3 16.7 1.9 9.0 0.1 6.9 8 0 0 8 8 8 0 HEAT repeat Fructosamin_kin PF03881.14 EFE39296.1 - 7.4e-60 202.6 0.0 1.1e-58 198.7 0.0 2.0 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EFE39296.1 - 0.00013 22.0 0.0 0.00024 21.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE39296.1 - 0.22 10.3 0.0 1.1 8.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) GST_N_3 PF13417.6 EFE39297.1 - 7.7e-16 58.3 0.0 1.5e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE39297.1 - 1.5e-15 57.2 0.1 3.2e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFE39297.1 - 1.2e-05 25.5 0.1 3.3e-05 24.2 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFE39297.1 - 0.023 14.7 0.0 0.044 13.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EFE39297.1 - 0.051 14.2 0.0 0.089 13.4 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFE39297.1 - 0.077 13.7 0.0 0.19 12.5 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain zf-C2H2_4 PF13894.6 EFE39298.1 - 3.1e-08 33.8 36.8 0.088 13.7 0.1 8.2 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE39298.1 - 1.3e-06 28.5 39.4 0.00093 19.5 0.5 8.4 7 1 1 8 8 8 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EFE39298.1 - 4.8e-06 26.7 43.9 0.074 13.4 0.6 7.9 6 2 2 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EFE39298.1 - 0.0023 17.9 18.6 0.0043 17.0 0.2 5.3 5 0 0 5 5 5 2 C2H2-type zinc finger zf-met PF12874.7 EFE39298.1 - 0.027 14.9 28.7 1.5 9.3 0.1 6.3 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFE39298.1 - 0.06 13.7 40.4 3.3 8.1 10.5 4.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Zn-C2H2_12 PF18112.1 EFE39298.1 - 9.6 6.8 16.4 5.3 7.6 0.2 3.9 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain Cyclin_N PF00134.23 EFE39299.1 - 0.0067 16.2 0.2 0.83 9.4 0.1 2.9 2 1 0 2 2 2 2 Cyclin, N-terminal domain CTP_transf_1 PF01148.20 EFE39300.1 - 4.8e-81 272.4 21.8 4.8e-81 272.4 21.8 2.1 2 0 0 2 2 2 2 Cytidylyltransferase family DUF3636 PF12331.8 EFE39301.1 - 8.1e-44 149.0 0.0 1.9e-43 147.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) Takusan PF04822.13 EFE39301.1 - 0.025 14.4 0.5 0.025 14.4 0.5 3.0 3 0 0 3 3 3 0 Takusan Bap31_Bap29_C PF18035.1 EFE39301.1 - 0.032 14.3 0.9 0.032 14.3 0.9 2.7 3 0 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF1192 PF06698.11 EFE39301.1 - 0.049 13.7 5.5 0.18 11.9 5.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Cep57_MT_bd PF06657.13 EFE39301.1 - 0.1 13.1 12.4 1.1 9.7 1.2 3.7 3 2 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 MOZART1 PF12554.8 EFE39301.1 - 0.1 12.4 0.0 0.4 10.5 0.0 1.9 2 0 0 2 2 2 0 Mitotic-spindle organizing gamma-tubulin ring associated Vps8 PF12816.7 EFE39301.1 - 0.13 11.8 0.1 1.6 8.2 0.0 2.4 2 0 0 2 2 2 0 Golgi CORVET complex core vacuolar protein 8 CorA PF01544.18 EFE39301.1 - 0.79 9.0 4.1 1.9 7.7 4.1 1.6 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Ndc1_Nup PF09531.10 EFE39301.1 - 1.3 7.6 13.0 1.7 7.2 3.9 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF4164 PF13747.6 EFE39301.1 - 3.6 7.9 13.7 0.18 12.1 3.7 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4164) FA_desaturase PF00487.24 EFE39303.1 - 1.3e-07 31.8 18.3 1.3e-07 31.8 18.3 1.7 1 1 1 2 2 2 2 Fatty acid desaturase GDPD PF03009.17 EFE39304.1 - 3.2e-17 63.1 0.0 4.3e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family adh_short PF00106.25 EFE39305.1 - 3.4e-17 62.5 0.0 2.9e-11 43.2 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase Epimerase PF01370.21 EFE39305.1 - 6.8e-05 22.4 0.0 0.13 11.7 0.0 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family KR PF08659.10 EFE39305.1 - 8.1e-05 22.6 0.0 0.00018 21.5 0.0 1.6 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 EFE39305.1 - 0.00021 20.6 0.2 0.00067 18.9 0.1 1.8 2 0 0 2 2 2 1 Male sterility protein adh_short_C2 PF13561.6 EFE39305.1 - 0.0034 17.0 0.0 0.042 13.4 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EFE39305.1 - 0.0034 17.3 0.0 0.5 10.2 0.0 2.5 2 0 0 2 2 2 2 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EFE39305.1 - 0.051 12.7 0.0 0.36 9.9 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein MFS_1 PF07690.16 EFE39306.1 - 3.8e-20 72.1 27.9 3.8e-20 72.1 27.9 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MTS PF05175.14 EFE39308.1 - 2.2e-06 27.3 0.0 0.00019 21.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EFE39308.1 - 2.8e-06 27.2 0.0 5.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE39308.1 - 0.00015 22.4 0.0 0.00041 21.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_10 PF05971.12 EFE39308.1 - 0.0003 20.3 0.0 0.00093 18.6 0.0 1.7 2 0 0 2 2 2 1 RNA methyltransferase PrmC_N PF17827.1 EFE39308.1 - 0.0013 19.3 2.8 0.0019 18.7 0.7 2.5 2 1 0 2 2 2 1 PrmC N-terminal domain PrmA PF06325.13 EFE39308.1 - 0.0042 16.5 0.0 0.0068 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EFE39308.1 - 0.0043 16.4 0.0 0.0062 15.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family AviRa PF11599.8 EFE39308.1 - 0.0089 15.5 0.0 0.016 14.7 0.0 1.5 1 0 0 1 1 1 1 RRNA methyltransferase AviRa N6_Mtase PF02384.16 EFE39308.1 - 0.011 15.0 0.0 0.031 13.5 0.0 1.7 1 1 0 1 1 1 0 N-6 DNA Methylase Methyltransf_12 PF08242.12 EFE39308.1 - 0.14 12.9 0.0 0.3 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Asp PF00026.23 EFE39309.1 - 5.2e-65 219.9 0.1 6.8e-65 219.5 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFE39309.1 - 7.7e-15 55.6 1.0 3.9e-11 43.5 1.6 3.1 2 1 0 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFE39309.1 - 1.3e-05 25.7 0.6 0.18 12.5 0.2 4.2 3 1 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 EFE39309.1 - 0.00019 21.9 0.2 0.17 12.5 0.0 3.7 3 1 0 3 3 3 1 gag-polyprotein putative aspartyl protease Lipocalin_4 PF13648.6 EFE39309.1 - 0.087 13.8 1.4 1.5 9.8 0.2 2.3 2 0 0 2 2 2 0 Lipocalin-like domain SLX9 PF15341.6 EFE39310.1 - 0.14 12.5 1.4 0.2 12.0 1.4 1.1 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Phage_holin_3_6 PF07332.11 EFE39310.1 - 0.44 10.6 6.9 0.9 9.6 0.4 2.6 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Ribosomal_L32p PF01783.23 EFE39310.1 - 0.58 10.5 5.4 0.86 9.9 2.2 2.2 1 1 1 2 2 2 0 Ribosomal L32p protein family TPR_12 PF13424.6 EFE39311.1 - 0.0036 17.6 1.2 4.3 7.7 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFE39311.1 - 0.0065 16.6 0.6 17 5.9 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFE39311.1 - 0.014 15.8 3.4 3.7 8.1 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFE39311.1 - 0.076 13.9 4.2 12 7.0 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat PH_10 PF15411.6 EFE39312.1 - 1.7e-25 89.7 0.2 2.9e-25 88.9 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain VWA PF00092.28 EFE39312.1 - 1.4e-12 48.2 0.0 2.4e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFE39312.1 - 2.6e-08 33.9 0.0 3.9e-07 30.1 0.0 2.7 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFE39312.1 - 2e-06 28.4 0.0 5.4e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-RING_5 PF14634.6 EFE39312.1 - 0.00021 21.1 4.0 0.00041 20.3 4.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFE39312.1 - 0.0018 18.5 4.8 0.0038 17.5 4.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFE39312.1 - 0.061 13.2 5.9 0.053 13.4 4.4 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE39312.1 - 0.068 13.1 1.9 0.14 12.0 1.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFE39312.1 - 0.12 12.7 2.3 0.28 11.5 2.3 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 EFE39312.1 - 0.13 11.9 5.9 0.047 13.3 2.9 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EFE39312.1 - 0.19 11.6 7.3 0.069 13.0 4.2 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFE39312.1 - 0.37 10.7 3.5 0.77 9.7 3.5 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 EFE39312.1 - 0.51 10.7 3.5 0.96 9.8 3.5 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3H2C3 PF17122.5 EFE39312.1 - 1.7 8.7 5.0 4.7 7.3 5.0 1.8 1 1 0 1 1 1 0 Zinc-finger Ribosomal_L12 PF00542.19 EFE39313.1 - 6e-22 77.8 8.3 1.6e-20 73.2 6.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EFE39313.1 - 2.4e-12 46.4 18.3 3.8e-12 45.7 10.5 3.6 3 1 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 EFE39313.1 - 0.0003 21.3 5.0 0.0003 21.3 5.0 2.2 2 1 0 2 2 2 1 60s Acidic ribosomal protein SpoVIF PF14069.6 EFE39313.1 - 0.096 12.5 3.1 0.2 11.4 0.3 2.5 2 1 0 2 2 2 0 Stage VI sporulation protein F Cpn60_TCP1 PF00118.24 EFE39314.1 - 1.3e-146 489.1 6.3 1.5e-146 488.9 6.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EAL PF00563.20 EFE39314.1 - 0.092 12.3 0.0 0.26 10.8 0.0 1.7 1 0 0 1 1 1 0 EAL domain CENP-B_dimeris PF09026.10 EFE39314.1 - 1.6 9.2 6.1 3.8 8.0 6.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EFE39314.1 - 8.8 6.0 7.6 3.4 7.3 4.0 1.9 2 0 0 2 2 2 0 FAM176 family E1_dh PF00676.20 EFE39315.1 - 2.3e-106 355.1 0.0 3.2e-106 354.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EFE39315.1 - 0.00015 21.1 0.0 0.00029 20.1 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase CCDC24 PF15669.5 EFE39316.1 - 0.0002 21.3 4.5 0.0002 21.3 4.5 2.4 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 24 family Mak10 PF04112.13 EFE39319.1 - 2.2e-51 173.7 0.0 4.2e-51 172.8 0.0 1.5 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase SpecificRecomb PF10136.9 EFE39319.1 - 0.046 12.0 0.0 0.054 11.8 0.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase HTH_AsnC-type PF13404.6 EFE39321.1 - 0.0036 17.1 0.0 0.022 14.6 0.0 2.2 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain Cpn60_TCP1 PF00118.24 EFE39322.1 - 2.5e-86 290.3 9.4 3.7e-86 289.7 9.4 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cofilin_ADF PF00241.20 EFE39323.1 - 6.3e-34 116.4 0.0 7.1e-34 116.2 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein COX4 PF02936.14 EFE39324.1 - 7.6e-41 139.4 0.1 1.1e-40 138.9 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF3106 PF11304.8 EFE39324.1 - 0.029 14.9 2.0 0.029 14.9 2.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) DUF1104 PF06518.11 EFE39324.1 - 0.065 13.6 0.2 0.15 12.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) DUF1138 PF06592.13 EFE39324.1 - 0.083 13.0 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1138) Alpha-amylase_C PF02806.18 EFE39325.1 - 4.7e-25 87.9 0.1 1.2e-24 86.5 0.1 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EFE39325.1 - 1.5e-16 60.9 0.3 3.5e-11 43.3 0.2 3.0 2 1 1 3 3 3 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 EFE39325.1 - 4.3e-16 59.0 0.0 1.3e-15 57.5 0.0 1.9 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) ATP-synt_ab PF00006.25 EFE39326.1 - 8.3e-62 208.6 0.0 1.4e-61 207.9 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EFE39326.1 - 8.4e-16 58.3 6.0 1.5e-13 51.0 0.4 3.0 3 0 0 3 3 3 2 ATP synthase alpha/beta family, beta-barrel domain AAA PF00004.29 EFE39326.1 - 0.016 15.6 0.0 0.79 10.1 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EFE39326.1 - 0.019 14.9 0.7 0.04 13.8 0.0 1.9 3 0 0 3 3 3 0 RsgA GTPase NB-ARC PF00931.22 EFE39326.1 - 0.026 13.7 0.2 0.12 11.5 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 EFE39326.1 - 0.039 13.9 0.0 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EFE39326.1 - 0.049 14.0 1.0 0.6 10.4 0.2 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EFE39326.1 - 0.05 13.5 0.2 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 NACHT domain ATPase PF06745.13 EFE39326.1 - 0.061 12.7 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 KaiC T3SS_ATPase_C PF18269.1 EFE39326.1 - 0.076 12.9 0.7 0.33 10.8 0.7 2.0 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain RNA_helicase PF00910.22 EFE39326.1 - 0.1 13.0 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 EFE39326.1 - 0.13 12.7 0.1 0.48 10.8 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain FAD_binding_4 PF01565.23 EFE39327.1 - 1.5e-19 70.1 0.3 2.8e-19 69.2 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE39327.1 - 2.2e-10 40.5 0.2 4.7e-10 39.4 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF4875 PF16175.5 EFE39327.1 - 0.13 12.4 0.2 0.4 10.8 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4875) AAA_2 PF07724.14 EFE39331.1 - 3.1e-38 131.6 0.0 4.1e-37 127.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EFE39331.1 - 1.2e-14 54.9 0.0 2.5e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EFE39331.1 - 2.8e-09 36.9 0.3 9.1e-09 35.3 0.0 1.9 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EFE39331.1 - 1.7e-06 28.1 0.0 3.7e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFE39331.1 - 0.00017 21.0 0.1 0.0077 15.6 0.0 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EFE39331.1 - 0.00031 20.5 0.0 0.095 12.4 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain MCM PF00493.23 EFE39331.1 - 0.0025 17.0 0.5 0.0064 15.6 0.1 1.8 2 0 0 2 2 2 1 MCM P-loop domain AAA_16 PF13191.6 EFE39331.1 - 0.003 17.9 0.1 0.011 16.2 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFE39331.1 - 0.0038 17.5 0.3 0.033 14.5 0.3 2.3 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFE39331.1 - 0.0048 16.7 0.0 0.0073 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFE39331.1 - 0.0048 16.6 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.12 EFE39331.1 - 0.0051 16.6 0.2 0.076 12.8 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EFE39331.1 - 0.042 13.4 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EFE39331.1 - 0.056 13.8 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EFE39331.1 - 0.061 13.8 0.0 0.14 12.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EFE39331.1 - 0.078 13.1 0.7 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EFE39331.1 - 0.092 12.6 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFE39331.1 - 0.098 12.7 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFE39331.1 - 0.1 13.2 0.6 0.24 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFE39331.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Chromo PF00385.24 EFE39332.1 - 1.6e-08 34.3 0.1 3.3e-08 33.3 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 EFE39332.1 - 0.0032 17.6 0.0 0.0072 16.5 0.0 1.6 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 Ras PF00071.22 EFE39333.1 - 1.1e-58 197.5 0.1 1.3e-58 197.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE39333.1 - 2.8e-34 117.9 0.2 3.9e-34 117.4 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE39333.1 - 4.2e-13 49.1 0.1 5.3e-13 48.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFE39333.1 - 2.5e-07 30.8 0.1 4.6e-07 29.9 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFE39333.1 - 2.7e-05 23.8 0.1 8.4e-05 22.2 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFE39333.1 - 8e-05 22.6 0.3 0.00098 19.1 0.1 2.1 1 1 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 EFE39333.1 - 0.00013 21.4 0.2 0.00017 21.0 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EFE39333.1 - 0.00058 20.2 0.1 0.0047 17.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFE39333.1 - 0.00067 20.1 0.0 0.0012 19.3 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EFE39333.1 - 0.0038 17.3 0.1 0.012 15.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EFE39333.1 - 0.011 15.2 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EFE39333.1 - 0.022 15.3 0.1 0.041 14.4 0.1 1.4 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 EFE39333.1 - 0.047 13.1 0.0 0.21 11.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein MCM PF00493.23 EFE39333.1 - 0.052 12.6 0.0 0.11 11.6 0.0 1.6 1 1 0 1 1 1 0 MCM P-loop domain SpoIIID PF12116.8 EFE39333.1 - 0.053 13.6 0.1 1 9.5 0.0 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D AAA_21 PF13304.6 EFE39333.1 - 0.056 13.2 0.5 0.083 12.7 0.5 1.4 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ATPase_2 PF01637.18 EFE39333.1 - 0.08 12.8 0.0 0.11 12.4 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EFE39333.1 - 0.095 12.4 0.1 0.23 11.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFE39333.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain F-box-like PF12937.7 EFE39334.1 - 4.8e-06 26.4 0.2 3.9e-05 23.5 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFE39334.1 - 0.044 13.7 0.0 0.15 12.0 0.0 1.9 1 0 0 1 1 1 0 F-box domain Brix PF04427.18 EFE39335.1 - 7e-32 111.1 0.0 9.6e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Brix domain BUD22 PF09073.10 EFE39335.1 - 0.093 12.1 11.1 0.024 14.0 6.7 1.9 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 EFE39335.1 - 0.15 10.2 7.9 0.25 9.5 7.9 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EFE39335.1 - 0.21 9.8 3.9 0.33 9.2 3.9 1.3 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 EFE39335.1 - 1.4 7.4 4.6 2 6.8 4.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 IFT57 PF10498.9 EFE39335.1 - 4.4 6.2 7.5 8 5.3 7.5 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 TRAP_alpha PF03896.16 EFE39335.1 - 9 5.4 7.1 19 4.3 7.1 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit XRCC4 PF06632.12 EFE39339.1 - 7.3e-07 28.4 15.9 2.6e-06 26.6 15.8 1.9 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3585 PF12130.8 EFE39339.1 - 0.051 13.7 7.4 0.036 14.2 5.6 1.7 1 1 1 2 2 2 0 Bivalent Mical/EHBP Rab binding domain Baculo_gp64 PF03273.13 EFE39339.1 - 0.091 11.6 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family ISG65-75 PF11727.8 EFE39339.1 - 0.26 10.5 7.1 0.42 9.8 7.1 1.4 1 0 0 1 1 1 0 Invariant surface glycoprotein SKA1 PF07160.12 EFE39339.1 - 0.41 10.5 11.9 0.019 14.9 6.4 1.5 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Fib_alpha PF08702.10 EFE39339.1 - 0.48 10.6 3.1 0.85 9.8 3.1 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family ZapB PF06005.12 EFE39339.1 - 0.63 10.5 7.7 2.6 8.6 7.7 2.1 1 1 0 1 1 1 0 Cell division protein ZapB DUF4407 PF14362.6 EFE39339.1 - 1.5 8.1 14.2 2.9 7.2 14.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 EFE39339.1 - 1.9 7.6 4.9 2.5 7.2 4.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein TMF_DNA_bd PF12329.8 EFE39339.1 - 3.6 7.6 11.1 3.8 7.6 4.2 3.4 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Molybdopterin PF00384.22 EFE39340.1 - 1.2e-70 238.6 0.0 1.9e-68 231.4 0.0 2.2 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH-G_4Fe-4S_3 PF10588.9 EFE39340.1 - 2.3e-17 62.2 0.2 2.3e-17 62.2 0.2 2.1 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 EFE39340.1 - 1.3e-11 45.0 0.0 3.6e-11 43.6 0.0 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer4 PF00037.27 EFE39340.1 - 0.1 12.4 1.1 2.9 7.9 0.3 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.11 EFE39340.1 - 0.21 11.7 2.1 4.1 7.6 2.1 2.5 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster Fer4_6 PF12837.7 EFE39340.1 - 0.34 11.1 2.4 0.44 10.7 1.0 1.9 2 0 0 2 2 2 0 4Fe-4S binding domain TPT PF03151.16 EFE39341.1 - 2.3e-58 197.9 17.0 2.7e-58 197.6 17.0 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family PSII PF00421.19 EFE39341.1 - 6.9e-06 25.0 0.0 1.2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Photosystem II protein EamA PF00892.20 EFE39341.1 - 2.1e-05 24.7 34.9 0.00057 20.1 12.1 2.8 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EFE39341.1 - 0.053 12.7 20.9 1 8.5 20.9 2.2 1 1 0 1 1 1 0 UAA transporter family Peptidase_S9 PF00326.21 EFE39342.1 - 1.6e-05 24.5 0.7 2.7e-05 23.8 0.7 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family FixG_C PF11614.8 EFE39342.1 - 0.11 12.7 0.1 0.38 11.0 0.1 1.9 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase PUF PF00806.19 EFE39343.1 - 5.5e-32 107.6 1.5 5.1e-06 25.9 0.0 8.2 8 0 0 8 8 8 6 Pumilio-family RNA binding repeat RraB PF06877.11 EFE39343.1 - 0.0073 17.0 0.2 0.044 14.5 0.0 2.3 3 0 0 3 3 3 1 Regulator of ribonuclease activity B DUF5572 PF17733.1 EFE39344.1 - 4.6e-25 87.2 0.2 1e-24 86.1 0.2 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Ssl1 PF04056.14 EFE39345.1 - 1.4e-73 246.9 0.0 1.9e-73 246.4 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EFE39345.1 - 1.2e-18 67.1 8.6 1.2e-18 67.1 8.6 2.4 2 1 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EFE39345.1 - 4.9e-15 56.1 0.0 1.1e-14 54.9 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain Tfb4 PF03850.14 EFE39345.1 - 0.00083 18.9 3.8 0.00083 18.9 3.8 1.9 2 0 0 2 2 2 1 Transcription factor Tfb4 DZR PF12773.7 EFE39345.1 - 0.2 11.7 18.9 2.2 8.4 5.7 2.9 2 1 0 2 2 2 0 Double zinc ribbon YL1 PF05764.13 EFE39345.1 - 1.7 8.7 9.5 2.3 8.3 9.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein DUF4796 PF16044.5 EFE39345.1 - 2.3 7.8 14.3 0.29 10.7 5.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4796) CDC45 PF02724.14 EFE39345.1 - 2.7 6.2 4.5 3.4 5.8 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein ERAP1_C PF11838.8 EFE39346.1 - 2.9e-87 293.2 0.0 6e-87 292.1 0.0 1.5 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EFE39346.1 - 1.1e-76 257.2 7.9 4.4e-54 183.4 6.1 2.3 2 0 0 2 2 2 2 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EFE39346.1 - 1.1e-39 136.6 0.1 4.5e-39 134.6 0.1 2.0 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Ras PF00071.22 EFE39347.1 - 3.6e-23 81.9 0.4 4.4e-23 81.7 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE39347.1 - 0.0023 18.2 0.3 0.0059 16.8 0.1 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase EIIBC-GUT_N PF03612.14 EFE39348.1 - 0.043 13.5 3.1 0.067 12.9 3.1 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF719 PF05334.13 EFE39348.1 - 0.53 10.5 5.4 0.55 10.4 4.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF719) Mito_carr PF00153.27 EFE39349.1 - 3.1e-56 187.3 1.9 2.8e-18 65.6 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 EFE39349.1 - 0.043 14.0 0.0 5.4 7.3 0.0 3.5 4 1 0 4 4 4 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Arteri_Gl PF00951.18 EFE39349.1 - 0.11 12.4 0.3 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein DUF3278 PF11683.8 EFE39349.1 - 0.11 12.6 0.0 0.33 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) TadE PF07811.12 EFE39349.1 - 0.63 10.4 4.0 3.3 8.1 0.3 2.7 2 0 0 2 2 2 0 TadE-like protein WD40 PF00400.32 EFE39350.1 - 0.072 14.0 10.9 2.9 8.9 2.1 4.6 4 1 0 4 4 4 0 WD domain, G-beta repeat UPF0029 PF01205.19 EFE39351.1 - 4.6e-36 123.3 0.1 7.5e-36 122.6 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EFE39351.1 - 0.0007 19.9 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 RWD domain Glyco_hydro_61 PF03443.14 EFE39352.1 - 4.6e-05 23.4 0.0 8e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Ribos_L4_asso_C PF14374.6 EFE39354.1 - 1.6e-30 105.0 0.9 2.6e-30 104.3 0.3 1.7 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Ribosomal_L4 PF00573.22 EFE39354.1 - 7.9e-25 87.7 0.1 1.1e-24 87.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family DSPc PF00782.20 EFE39355.1 - 7.2e-07 29.1 0.0 9.4e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF1877 PF08974.10 EFE39355.1 - 0.079 13.0 0.0 0.095 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) BCS1_N PF08740.11 EFE39356.1 - 1.7e-40 139.0 3.0 3.4e-40 138.0 3.0 1.5 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EFE39356.1 - 3.7e-17 63.0 0.0 6e-15 55.8 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFE39356.1 - 0.0069 16.8 0.1 0.1 13.0 0.0 2.7 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFE39356.1 - 0.0086 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EFE39356.1 - 0.025 14.0 0.0 0.046 13.1 0.0 1.4 1 0 0 1 1 1 0 KaiC CCDC53 PF10152.9 EFE39356.1 - 0.08 13.4 3.4 0.23 11.9 0.7 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex AAA_5 PF07728.14 EFE39356.1 - 0.15 12.0 0.0 0.53 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NAAA-beta PF15508.6 EFE39357.1 - 8e-06 26.1 0.2 1.7e-05 25.0 0.2 1.6 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase DUF3395 PF11875.8 EFE39358.1 - 1e-39 135.9 0.0 1.9e-39 135.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EFE39358.1 - 5.3e-16 58.5 0.0 1.2e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain RicinB_lectin_2 PF14200.6 EFE39360.1 - 0.093 13.5 0.1 12 6.8 0.1 2.4 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like PRIMA1 PF16101.5 EFE39360.1 - 1.5 8.9 11.6 5.8 7.0 9.9 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 EFE39360.1 - 7.2 6.6 5.4 12 5.8 5.4 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator SKIP_SNW PF02731.15 EFE39361.1 - 8.3e-72 240.1 5.7 8.3e-72 240.1 5.7 2.3 3 0 0 3 3 3 1 SKIP/SNW domain Nucleo_P87 PF07267.11 EFE39361.1 - 2.1 7.1 11.5 5.5 5.7 11.5 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 WD40 PF00400.32 EFE39362.1 - 7.4e-38 127.9 33.1 8.1e-09 36.0 0.7 13.0 13 0 0 13 13 13 7 WD domain, G-beta repeat Utp12 PF04003.12 EFE39362.1 - 8.8e-28 96.7 0.0 1.4e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EFE39362.1 - 1.9e-22 79.4 0.0 0.0075 16.5 0.0 9.4 5 2 6 11 11 11 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE39362.1 - 4.2e-10 39.1 1.0 0.25 10.2 0.0 5.4 4 2 2 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFE39362.1 - 1.3e-07 31.7 1.0 0.0085 16.0 0.1 4.9 6 1 1 7 7 7 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EFE39362.1 - 2.2e-06 26.7 5.2 0.64 8.6 0.0 5.1 2 2 2 5 5 5 3 Nucleoporin Nup120/160 ELYS-bb PF16687.5 EFE39362.1 - 0.0031 16.2 0.1 0.031 12.9 0.0 2.5 3 1 1 4 4 4 1 beta-propeller of ELYS nucleoporin WD40_like PF17005.5 EFE39362.1 - 0.036 13.4 0.0 2 7.7 0.0 3.3 4 0 0 4 4 4 0 WD40-like domain Pox_T4_N PF04491.12 EFE39362.1 - 0.043 13.7 0.4 0.26 11.2 0.1 2.3 2 0 0 2 2 2 0 Poxvirus T4 protein, N terminus PQQ_3 PF13570.6 EFE39362.1 - 0.052 14.1 0.4 61 4.3 0.0 4.7 4 0 0 4 4 4 0 PQQ-like domain Coatomer_WDAD PF04053.14 EFE39362.1 - 0.13 11.3 0.0 9.6 5.1 0.0 3.3 4 0 0 4 4 4 0 Coatomer WD associated region Septin PF00735.18 EFE39363.1 - 1.4e-108 362.5 0.3 2.1e-108 361.9 0.3 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EFE39363.1 - 1.1e-06 28.7 0.0 2.4e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFE39363.1 - 1.1e-05 25.1 0.8 0.00081 19.0 0.1 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFE39363.1 - 4.2e-05 23.5 0.1 0.00049 20.0 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EFE39363.1 - 0.0098 16.2 0.2 0.032 14.5 0.0 1.9 2 1 0 2 2 2 1 AAA domain FOXP-CC PF16159.5 EFE39363.1 - 0.018 15.6 0.9 0.052 14.2 0.9 1.7 1 0 0 1 1 1 0 FOXP coiled-coil domain Roc PF08477.13 EFE39363.1 - 0.052 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EFE39363.1 - 0.09 12.1 0.1 0.22 10.8 0.0 1.7 2 0 0 2 2 2 0 AIG1 family Pox_A32 PF04665.12 EFE39363.1 - 0.098 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein Ras PF00071.22 EFE39363.1 - 0.14 11.7 0.2 0.39 10.3 0.2 1.7 1 1 0 1 1 1 0 Ras family WD40 PF00400.32 EFE39364.1 - 4e-17 62.3 12.6 7.4e-05 23.4 0.5 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39364.1 - 9.5e-09 35.4 0.1 0.024 14.9 0.0 4.3 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EFE39364.1 - 2e-07 30.6 0.5 0.016 15.1 0.0 4.0 4 0 0 4 4 4 2 PQQ enzyme repeat VID27 PF08553.10 EFE39364.1 - 0.028 13.5 0.0 0.091 11.8 0.1 1.9 2 1 0 2 2 2 0 VID27 C-terminal WD40-like domain Ge1_WD40 PF16529.5 EFE39364.1 - 0.062 12.2 1.2 1.1 8.2 0.0 2.8 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ACT_7 PF13840.6 EFE39365.1 - 2.3e-20 72.2 0.1 3e-11 42.9 0.0 2.4 2 0 0 2 2 2 2 ACT domain XRN_M PF17846.1 EFE39366.1 - 1e-98 331.2 3.1 2.3e-98 330.1 3.1 1.4 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EFE39366.1 - 7.2e-98 326.8 0.0 1.2e-97 326.2 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 EFE39366.1 - 8.8e-74 247.4 2.9 1.4e-73 246.8 0.1 2.2 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 EFE39366.1 - 3.7e-33 113.6 0.0 1e-32 112.2 0.0 1.8 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 EFE39366.1 - 2.8e-23 81.8 0.1 7.4e-23 80.4 0.1 1.8 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 EFE39366.1 - 9.8e-10 38.4 0.5 2.5e-09 37.1 0.5 1.7 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 DUF2207 PF09972.9 EFE39366.1 - 0.075 11.8 0.7 0.13 11.0 0.7 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Cwf_Cwc_15 PF04889.12 EFE39366.1 - 0.79 9.4 7.8 1.5 8.5 7.8 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXLR PF16810.5 EFE39366.1 - 1.2 9.5 3.4 2.7 8.4 3.4 1.5 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity CAF1C_H4-bd PF12265.8 EFE39367.1 - 2.8e-29 101.2 0.6 2e-28 98.4 0.9 2.4 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EFE39367.1 - 3.9e-28 97.1 8.2 3e-05 24.7 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39367.1 - 1.3e-06 28.6 1.2 0.14 12.5 0.1 4.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain GTP_cyclohydroI PF01227.22 EFE39368.1 - 4.7e-68 228.1 0.1 7.7e-68 227.4 0.1 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EFE39368.1 - 0.0011 19.0 0.0 0.0023 18.1 0.0 1.5 1 0 0 1 1 1 1 QueF-like protein Cu_amine_oxidN2 PF02727.16 EFE39368.1 - 0.036 14.3 0.0 0.094 13.0 0.0 1.7 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain FDF PF09532.10 EFE39368.1 - 0.083 13.8 0.2 0.13 13.1 0.2 1.4 1 0 0 1 1 1 0 FDF domain Questin_oxidase PF14027.6 EFE39370.1 - 5.6e-94 315.5 0.1 6.6e-94 315.2 0.1 1.1 1 0 0 1 1 1 1 Questin oxidase-like Lactamase_B_5 PF14597.6 EFE39370.1 - 0.0023 17.4 0.0 0.0043 16.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Pkinase PF00069.25 EFE39371.1 - 6.1e-71 238.9 0.0 8.4e-71 238.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39371.1 - 2.9e-33 115.2 0.0 5.5e-33 114.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFE39371.1 - 0.00023 20.6 0.7 0.00052 19.4 0.7 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFE39371.1 - 0.00048 19.5 0.5 0.0028 17.0 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFE39371.1 - 0.017 13.9 0.1 0.017 13.9 0.1 2.2 3 0 0 3 3 3 0 Fungal protein kinase Haspin_kinase PF12330.8 EFE39371.1 - 0.027 13.4 0.0 0.086 11.8 0.0 1.8 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EFE39371.1 - 0.05 13.5 9.8 0.071 13.0 0.0 3.3 3 0 0 3 3 3 0 Phosphotransferase enzyme family NUDIX PF00293.28 EFE39372.1 - 2.8e-16 59.7 0.0 5.7e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 EFE39372.1 - 5.9e-10 39.7 0.0 4.6e-09 36.8 0.0 2.3 2 1 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 EFE39372.1 - 2.5e-06 27.1 1.2 4.1e-06 26.3 1.2 1.3 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain MPM1 PF17234.2 EFE39373.1 - 0.064 13.5 3.9 0.15 12.4 3.9 1.6 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 FSIP1 PF15554.6 EFE39373.1 - 0.28 10.2 10.3 3.9 6.5 10.3 2.1 1 1 0 1 1 1 0 FSIP1 family Dynamin_N PF00350.23 EFE39374.1 - 6.3e-20 71.9 0.0 1.4e-19 70.8 0.0 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFE39374.1 - 1.9e-14 53.6 0.1 5.3e-14 52.1 0.1 1.8 1 1 0 1 1 1 1 Dynamin central region FeoB_N PF02421.18 EFE39374.1 - 6.4e-05 22.5 0.5 0.034 13.7 0.1 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EFE39374.1 - 0.00022 21.3 0.0 0.0017 18.4 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase GED PF02212.18 EFE39374.1 - 0.016 15.3 0.6 0.066 13.4 0.1 2.3 2 0 0 2 2 2 0 Dynamin GTPase effector domain AAA_15 PF13175.6 EFE39374.1 - 0.027 14.2 0.1 0.31 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EFE39374.1 - 0.038 14.5 0.0 0.45 11.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain EF-G-binding_N PF07299.11 EFE39374.1 - 0.098 13.2 0.2 0.42 11.2 0.2 2.1 1 0 0 1 1 1 0 Elongation factor G-binding protein, N-terminal ERCC3_RAD25_C PF16203.5 EFE39375.1 - 1.2e-122 407.9 0.7 2.1e-122 407.1 0.7 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EFE39375.1 - 1.5e-33 115.7 0.0 5.9e-33 113.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE39375.1 - 1.8e-14 54.1 0.0 4.1e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFE39375.1 - 7.4e-14 52.0 0.1 1.7e-13 50.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EFE39375.1 - 2.7e-07 29.6 0.0 3.5e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_34 PF13872.6 EFE39375.1 - 0.00095 18.1 0.0 0.0016 17.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DUF4677 PF15726.5 EFE39375.1 - 0.061 13.5 1.1 0.16 12.2 1.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) DUF3669 PF12417.8 EFE39376.1 - 6.2e-19 68.0 0.0 1.4e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 Zinc finger protein DUF3669 PF12417.8 EFE39377.1 - 3.2e-18 65.7 0.5 2.6e-17 62.8 0.0 2.3 2 0 0 2 2 2 1 Zinc finger protein CTD_bind PF04818.13 EFE39378.1 - 3.6e-11 43.7 0.0 9.9e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase II-binding domain. EMP24_GP25L PF01105.24 EFE39379.1 - 1.1e-42 146.1 0.1 1.8e-42 145.3 0.1 1.4 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD USP7_ICP0_bdg PF12436.8 EFE39380.1 - 5.2e-87 291.1 0.0 1.1e-85 286.9 0.0 2.3 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 EFE39380.1 - 3.7e-60 203.2 0.2 3.1e-59 200.1 0.1 2.4 2 1 0 2 2 2 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 EFE39380.1 - 2.9e-45 154.8 0.3 4.9e-45 154.0 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE39380.1 - 1.4e-20 74.2 0.0 3e-20 73.0 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rad60-SLD PF11976.8 EFE39380.1 - 0.063 13.1 0.8 1.6 8.6 0.0 3.5 4 1 0 4 4 4 0 Ubiquitin-2 like Rad60 SUMO-like BCDHK_Adom3 PF10436.9 EFE39382.1 - 1.5e-28 99.7 0.0 3.2e-28 98.6 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EFE39382.1 - 1.4e-06 28.8 0.0 9.6e-06 26.1 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFE39382.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EFE39382.1 - 0.12 12.4 0.0 1.8 8.6 0.0 2.3 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain SPC22 PF04573.12 EFE39383.1 - 2.2e-39 134.7 0.4 6.1e-37 126.7 0.4 2.1 1 1 0 1 1 1 1 Signal peptidase subunit Peptidase_C48 PF02902.19 EFE39384.1 - 1.9e-32 112.9 0.1 1.2e-31 110.2 0.1 2.0 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain ATXN-1_C PF12547.8 EFE39385.1 - 0.82 10.1 3.5 19 5.7 0.1 2.6 2 0 0 2 2 2 0 Capicua transcriptional repressor modulator IF4E PF01652.18 EFE39386.1 - 5.3e-52 175.8 0.2 8.5e-52 175.1 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Aminotran_1_2 PF00155.21 EFE39387.1 - 1.1e-26 93.9 0.0 1.3e-26 93.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_3 PF00202.21 EFE39387.1 - 0.00085 18.1 0.0 0.045 12.4 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-III POT1 PF02765.17 EFE39388.1 - 1e-18 67.5 0.0 2e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 FMO-like PF00743.19 EFE39389.1 - 2.5e-41 141.7 0.0 6.7e-23 80.9 0.0 3.0 2 1 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFE39389.1 - 4.4e-13 49.2 0.2 1.1e-08 34.7 0.0 3.1 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFE39389.1 - 3.1e-09 36.5 0.1 5.7e-08 32.3 0.1 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFE39389.1 - 5.4e-06 26.6 0.0 1.5e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFE39389.1 - 3.7e-05 23.0 0.0 0.00022 20.5 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EFE39389.1 - 0.0013 18.0 0.0 0.056 12.7 0.0 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 EFE39389.1 - 0.0017 18.4 0.1 0.025 14.6 0.2 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 EFE39389.1 - 0.11 12.1 0.1 19 4.7 0.1 2.7 3 1 0 3 3 3 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EFE39389.1 - 0.21 10.3 0.0 0.64 8.6 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein HDA2-3 PF11496.8 EFE39391.1 - 2.7e-37 128.5 1.0 3.7e-35 121.5 0.0 3.0 2 2 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Fez1 PF06818.15 EFE39391.1 - 0.0084 16.6 20.0 0.0084 16.6 20.0 2.7 1 1 1 2 2 2 1 Fez1 DUF745 PF05335.13 EFE39391.1 - 0.013 15.2 20.4 0.068 12.9 6.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF745) CENP-F_leu_zip PF10473.9 EFE39391.1 - 0.032 14.3 42.2 1.6 8.7 16.4 3.6 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 EFE39391.1 - 1.4 9.1 24.3 3.9 7.7 3.6 3.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF2207 PF09972.9 EFE39391.1 - 2.5 6.8 4.6 4.4 5.9 4.6 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4407 PF14362.6 EFE39391.1 - 5.9 6.2 33.7 0.028 13.8 15.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 EFE39391.1 - 9.7 6.2 22.9 0.23 11.5 9.3 3.6 1 1 3 4 4 4 0 Laminin Domain II MIP PF00230.20 EFE39392.1 - 2.9e-42 144.9 11.4 3.7e-42 144.6 11.4 1.0 1 0 0 1 1 1 1 Major intrinsic protein Transglut_core PF01841.19 EFE39393.1 - 2.1e-11 44.3 0.2 5.7e-11 42.8 0.2 1.8 2 0 0 2 2 2 1 Transglutaminase-like superfamily SH3_2 PF07653.17 EFE39393.1 - 1.5e-08 34.2 0.1 3.7e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFE39393.1 - 1.2e-05 24.9 0.1 1.2e-05 24.9 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EFE39393.1 - 0.00059 19.7 0.1 0.011 15.5 0.1 2.5 2 0 0 2 2 2 1 Variant SH3 domain Transglut_core2 PF13369.6 EFE39393.1 - 0.066 12.8 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily DHHA2 PF02833.14 EFE39394.1 - 3.9e-32 111.4 0.0 7.3e-32 110.5 0.0 1.5 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EFE39394.1 - 6.1e-06 26.4 0.0 2.9e-05 24.2 0.0 2.2 1 1 0 1 1 1 1 DHH family Zn_clus PF00172.18 EFE39395.1 - 6.3e-07 29.4 12.2 1.4e-06 28.3 12.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tmemb_cc2 PF10267.9 EFE39395.1 - 0.15 11.2 0.3 0.21 10.7 0.3 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein TPR_2 PF07719.17 EFE39397.1 - 2.5e-25 86.5 8.2 0.0039 17.2 0.0 10.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.28 EFE39397.1 - 1.3e-22 78.6 8.2 0.0021 17.8 0.4 9.9 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFE39397.1 - 1.8e-14 52.6 6.7 0.019 15.1 0.0 8.3 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFE39397.1 - 3e-14 53.1 23.2 4.1e-08 33.4 0.3 9.1 8 2 2 10 10 10 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFE39397.1 - 1.7e-12 47.7 9.4 0.0024 18.3 0.0 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFE39397.1 - 3.1e-09 36.9 13.5 1.9 9.5 0.4 7.6 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFE39397.1 - 7.2e-09 35.2 15.7 0.00012 21.8 0.1 6.8 9 0 0 9 9 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE39397.1 - 3.3e-07 30.4 16.9 3.4e-05 24.0 0.2 5.9 5 2 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EFE39397.1 - 3.9e-07 30.6 17.8 0.055 14.1 0.6 7.7 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFE39397.1 - 2.4e-06 27.1 4.8 0.37 10.5 0.1 6.4 7 1 1 8 8 8 2 TPR repeat TPR_7 PF13176.6 EFE39397.1 - 1.1e-05 25.1 17.9 0.91 9.7 0.1 8.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFE39397.1 - 3.1e-05 24.3 5.7 11 6.9 0.1 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFE39397.1 - 0.00021 21.4 6.2 7.8 7.1 0.0 7.0 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_4 PF07721.14 EFE39397.1 - 0.045 14.4 8.4 0.22 12.3 0.4 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 EFE39397.1 - 0.078 12.7 2.4 20 4.8 0.2 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat-like domain DUF572 PF04502.13 EFE39398.1 - 1.1e-69 235.6 13.8 1.3e-69 235.4 13.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Trypan_glycop PF00913.19 EFE39398.1 - 0.0099 15.2 0.5 0.012 14.9 0.5 1.2 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF951 PF06107.11 EFE39398.1 - 0.042 13.8 0.1 3.5 7.6 0.0 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) HypA PF01155.19 EFE39398.1 - 0.07 13.2 0.6 2 8.5 0.1 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DNA_RNApol_7kD PF03604.13 EFE39398.1 - 0.095 12.4 2.4 7.8 6.3 0.4 2.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-FCS PF06467.14 EFE39398.1 - 0.12 12.4 3.6 0.75 9.8 0.2 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif DUF866 PF05907.13 EFE39398.1 - 0.19 11.7 3.8 0.46 10.4 3.8 1.7 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) TF_Zn_Ribbon PF08271.12 EFE39398.1 - 0.54 9.8 6.0 0.88 9.1 1.3 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 EFE39398.1 - 0.77 9.6 3.6 1.1 9.0 0.7 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-ACC PF17848.1 EFE39398.1 - 2.1 8.5 5.5 3.4 7.8 0.8 2.6 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Zn_ribbon_SprT PF17283.2 EFE39398.1 - 3.5 7.6 6.0 5.3 7.0 0.5 2.2 1 1 1 2 2 2 0 SprT-like zinc ribbon domain FAT PF02259.23 EFE39399.1 - 9.1e-72 242.1 13.3 1.9e-71 241.1 13.3 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 EFE39399.1 - 4.1e-35 121.8 0.1 9.8e-35 120.6 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EFE39399.1 - 7e-06 25.8 0.1 2e-05 24.3 0.1 1.9 1 0 0 1 1 1 1 FATC domain Gluconate_2-dh3 PF13618.6 EFE39399.1 - 0.072 13.3 0.0 12 6.2 0.0 3.0 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 DUF2576 PF10845.8 EFE39399.1 - 0.11 12.1 0.0 0.39 10.4 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) HEAT PF02985.22 EFE39399.1 - 0.16 12.3 0.1 38 4.9 0.1 4.5 3 0 0 3 3 3 0 HEAT repeat B56 PF01603.20 EFE39400.1 - 3.5e-190 632.4 4.6 4.1e-190 632.1 4.6 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EFE39400.1 - 0.0015 18.4 3.1 0.71 9.8 0.1 2.5 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Tau95 PF09734.9 EFE39401.1 - 4.2e-40 137.8 0.5 8.1e-40 136.9 0.5 1.5 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EFE39401.1 - 4.3e-31 107.7 0.1 1.1e-30 106.5 0.1 1.6 1 0 0 1 1 1 1 Tau95 Triple barrel domain RNA_pol_3_Rpc31 PF11705.8 EFE39401.1 - 1.4 9.2 14.1 2.8 8.1 14.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 FAP PF07174.11 EFE39403.1 - 1.6 8.1 21.4 1.7 8.1 21.4 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) PAN_1 PF00024.26 EFE39404.1 - 4.7e-08 32.9 24.1 0.00045 20.1 5.6 2.7 2 1 0 2 2 2 2 PAN domain PAN_3 PF08277.12 EFE39404.1 - 0.0039 17.0 7.4 0.35 10.7 0.3 2.8 2 0 0 2 2 2 2 PAN-like domain PAN_4 PF14295.6 EFE39404.1 - 0.0048 16.8 9.4 0.0099 15.8 3.8 3.8 4 0 0 4 4 4 2 PAN domain PfkB PF00294.24 EFE39405.1 - 1.8e-40 139.2 0.1 4.1e-40 138.0 0.1 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase p6 PF17548.2 EFE39405.1 - 0.085 12.8 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 Histone-like Protein p6 ECH_1 PF00378.20 EFE39406.1 - 8.7e-37 126.8 0.1 5.6e-24 84.8 0.1 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFE39406.1 - 3.9e-17 62.7 0.0 4.2e-08 33.1 0.0 2.0 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase MCM PF00493.23 EFE39407.1 - 4.8e-104 346.3 0.2 1e-103 345.3 0.1 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EFE39407.1 - 1.1e-36 125.5 0.8 1.9e-36 124.7 0.8 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFE39407.1 - 1.8e-23 82.8 1.3 4.9e-23 81.4 1.3 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFE39407.1 - 6.2e-07 29.0 0.0 0.00012 21.5 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFE39407.1 - 1.8e-05 24.8 0.0 3.9e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFE39407.1 - 0.00067 19.5 0.1 0.0027 17.6 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_7 PF17867.1 EFE39407.1 - 0.0019 18.4 0.1 0.0065 16.7 0.1 1.9 1 0 0 1 1 1 1 Midasin AAA lid domain Sigma54_activat PF00158.26 EFE39407.1 - 0.017 14.9 0.1 0.21 11.3 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain Imm35 PF15567.6 EFE39407.1 - 0.15 12.2 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 35 SET PF00856.28 EFE39408.1 - 5.3e-09 36.7 0.0 1.6e-08 35.1 0.0 1.7 1 1 0 1 1 1 1 SET domain DEAD PF00270.29 EFE39410.1 - 5.5e-32 110.9 0.0 1e-31 110.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE39410.1 - 6.5e-20 71.5 0.4 2.6e-17 63.2 0.3 2.7 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EFE39410.1 - 6.9e-05 22.9 0.1 0.0017 18.4 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EFE39410.1 - 0.14 10.8 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain Anillin PF08174.11 EFE39411.1 - 8.8e-09 35.9 0.7 1.7e-08 35.0 0.0 2.0 2 0 0 2 2 2 1 Cell division protein anillin PH PF00169.29 EFE39411.1 - 1.4e-07 32.0 0.0 5.2e-07 30.1 0.0 2.0 1 0 0 1 1 1 1 PH domain PseudoU_synth_1 PF01416.20 EFE39412.1 - 1.6e-10 41.4 0.0 3.3e-08 34.0 0.0 2.7 2 0 0 2 2 2 2 tRNA pseudouridine synthase Arylsulfotran_N PF17425.2 EFE39413.1 - 0.087 12.9 1.1 2.8 8.0 0.1 2.8 2 0 0 2 2 2 0 Arylsulfotransferase Ig-like domain TrkH PF02386.16 EFE39414.1 - 1.1e-99 334.2 4.1 1.9e-97 326.8 1.4 2.5 2 1 0 2 2 2 2 Cation transport protein MFS_1 PF07690.16 EFE39415.1 - 5.4e-11 42.0 54.1 5.4e-11 42.0 54.1 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily PALP PF00291.25 EFE39416.1 - 4.9e-45 154.2 0.2 6.5e-45 153.8 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme p47_phox_C PF08944.11 EFE39417.1 - 1.7 8.2 6.6 0.083 12.3 0.7 1.9 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain DUF3517 PF12030.8 EFE39418.1 - 1.1e-90 303.9 1.1 1.7e-90 303.3 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH PF00443.29 EFE39418.1 - 1.6e-39 136.0 0.0 2.4e-39 135.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE39418.1 - 9.1e-15 55.1 0.2 5.4e-06 26.2 0.0 2.7 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUF4110 PF13422.6 EFE39418.1 - 0.15 12.2 0.0 0.55 10.3 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) RNase_P_pop3 PF08228.11 EFE39419.1 - 2.5e-05 24.4 0.0 4.8e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 RNase P subunit Pop3 Hexapep PF00132.24 EFE39420.1 - 1.1e-11 44.0 12.0 1.1e-10 40.7 4.9 3.2 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFE39420.1 - 5.6e-11 42.0 10.4 2.6e-10 39.9 3.7 2.7 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 EFE39420.1 - 4.5e-09 36.4 0.2 7.2e-09 35.8 0.2 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Ank_4 PF13637.6 EFE39421.1 - 7.2e-37 125.3 13.0 2.4e-07 31.2 0.0 7.0 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFE39421.1 - 7.9e-35 119.3 7.2 5.2e-12 46.2 1.5 5.9 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFE39421.1 - 7.2e-33 112.2 15.3 7.6e-10 38.9 0.1 6.4 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE39421.1 - 2e-25 86.1 16.2 1.1e-05 25.4 0.0 8.7 8 0 0 8 8 8 7 Ankyrin repeat Ank PF00023.30 EFE39421.1 - 2e-23 81.7 21.6 2.1e-06 27.9 0.1 8.4 8 1 1 9 9 9 4 Ankyrin repeat AIRC PF00731.20 EFE39422.1 - 3e-59 198.8 1.7 5.9e-59 197.9 1.7 1.5 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 EFE39422.1 - 2.6e-42 144.3 0.0 2.5e-41 141.1 0.0 2.3 1 1 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EFE39422.1 - 1.3e-18 66.4 0.0 3.1e-18 65.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain PrpR_N PF06506.11 EFE39422.1 - 0.00072 19.2 0.7 0.005 16.4 0.1 2.3 2 0 0 2 2 2 1 Propionate catabolism activator AlaDh_PNT_C PF01262.21 EFE39422.1 - 0.00081 18.7 0.2 0.0018 17.6 0.2 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain CPSase_L_D2 PF02786.17 EFE39422.1 - 0.0025 17.4 0.6 0.17 11.4 0.0 2.8 2 1 1 3 3 3 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 EFE39422.1 - 0.034 13.7 0.0 2.4 7.6 0.0 2.4 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus CoA_binding_2 PF13380.6 EFE39422.1 - 0.18 12.3 0.7 26 5.3 0.0 3.2 2 1 1 3 3 3 0 CoA binding domain SCA7 PF08313.12 EFE39423.1 - 4.6e-31 106.5 0.2 4.6e-31 106.5 0.2 2.3 3 0 0 3 3 3 1 SCA7, zinc-binding domain DUF2151 PF10221.9 EFE39423.1 - 0.095 11.3 7.1 0.13 10.8 7.1 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Neugrin PF06413.11 EFE39423.1 - 0.43 10.6 6.9 0.82 9.6 6.9 1.5 1 0 0 1 1 1 0 Neugrin ATP-synt_Eps PF04627.13 EFE39423.1 - 1.8 8.6 6.7 4.5 7.3 6.7 1.7 1 0 0 1 1 1 0 Mitochondrial ATP synthase epsilon chain CDC45 PF02724.14 EFE39423.1 - 2.2 6.5 7.3 3.2 5.9 7.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 EFE39423.1 - 2.3 7.1 6.3 4.1 6.3 6.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2052 PF09747.9 EFE39423.1 - 9.8 6.2 10.5 13 5.8 9.2 1.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) mRNA_cap_enzyme PF01331.19 EFE39424.1 - 6e-52 176.3 0.4 8.5e-52 175.8 0.4 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EFE39424.1 - 6.9e-36 123.2 0.0 1.4e-35 122.2 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EFE39424.1 - 1.1e-08 35.0 0.6 7.9e-07 28.9 0.2 2.5 1 1 1 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_M PF01068.21 EFE39425.1 - 2.3e-60 203.8 0.5 4e-58 196.4 0.5 2.5 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFE39425.1 - 3.5e-43 147.9 0.1 7.7e-43 146.8 0.1 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EFE39425.1 - 1.2e-27 96.4 0.0 4.9e-27 94.4 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region MotA_ExbB PF01618.16 EFE39425.1 - 0.2 11.4 0.6 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family PT PF04886.12 EFE39426.1 - 0.0026 17.2 20.4 1 9.0 15.9 3.4 2 1 0 2 2 2 1 PT repeat Pkinase PF00069.25 EFE39428.1 - 3.9e-62 210.0 0.0 4.7e-61 206.5 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Fungal_KA1 PF16797.5 EFE39428.1 - 1.3e-32 112.0 0.3 2.7e-32 111.0 0.3 1.6 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Pkinase_Tyr PF07714.17 EFE39428.1 - 1.3e-31 109.8 0.0 1.8e-30 106.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE39428.1 - 7.1e-05 22.3 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFE39428.1 - 0.028 13.4 0.0 0.063 12.2 0.0 1.6 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EFE39428.1 - 0.11 12.5 0.0 0.39 10.6 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Alpha-amylase PF00128.24 EFE39428.1 - 0.18 11.3 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 Alpha amylase, catalytic domain DAO PF01266.24 EFE39429.1 - 1.3e-28 100.6 0.0 1.5e-28 100.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFE39429.1 - 0.0048 16.2 0.0 0.011 15.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFE39429.1 - 0.03 14.3 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding DUF1690 PF07956.11 EFE39430.1 - 4.3e-34 117.9 3.1 1.3e-17 64.5 0.1 2.2 2 0 0 2 2 2 2 Protein of Unknown function (DUF1690) Rootletin PF15035.6 EFE39430.1 - 0.067 13.2 2.3 0.27 11.2 0.3 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion POP1 PF06978.11 EFE39431.1 - 1.7e-74 250.3 14.0 3.5e-74 249.2 14.0 1.6 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EFE39431.1 - 4.7e-33 113.4 1.8 1.3e-32 111.9 1.8 1.8 1 0 0 1 1 1 1 POPLD (NUC188) domain Redoxin PF08534.10 EFE39432.1 - 4.1e-36 123.9 0.0 4.8e-36 123.7 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EFE39432.1 - 1.2e-11 44.6 0.0 1.6e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Hexokinase_2 PF03727.16 EFE39433.1 - 6.6e-73 245.1 0.0 1e-72 244.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EFE39433.1 - 1.1e-71 240.9 0.0 1.6e-71 240.3 0.0 1.3 1 0 0 1 1 1 1 Hexokinase zf-C2HC5 PF06221.13 EFE39433.1 - 3.3e-21 75.0 6.5 6.2e-21 74.1 6.5 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Tropomodulin PF03250.14 EFE39433.1 - 3.9 7.5 8.4 9.6 6.3 3.2 2.4 1 1 1 2 2 2 0 Tropomodulin FSA_C PF10479.9 EFE39433.1 - 6.9 4.7 11.6 13 3.8 11.6 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Phospholip_A2_3 PF09056.11 EFE39434.1 - 5.6e-40 136.4 5.1 6.6e-40 136.2 5.1 1.0 1 0 0 1 1 1 1 Prokaryotic phospholipase A2 DUF604 PF04646.12 EFE39436.1 - 3.3e-07 30.0 0.0 5.6e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Fringe PF02434.16 EFE39436.1 - 0.00086 18.8 0.0 0.002 17.6 0.0 1.6 1 1 0 1 1 1 1 Fringe-like GDI PF00996.18 EFE39438.1 - 4.1e-30 104.7 0.0 5.4e-30 104.3 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Pro_isomerase PF00160.21 EFE39439.1 - 9.4e-47 159.2 0.0 1.1e-46 159.0 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_A22B PF04258.13 EFE39440.1 - 5.7e-59 200.0 0.2 2.7e-58 197.7 0.2 1.9 1 1 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 EFE39440.1 - 0.00053 19.6 3.8 0.00053 19.6 3.8 2.1 2 1 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease RNase_PH PF01138.21 EFE39441.1 - 4.7e-09 36.8 0.1 2.6e-07 31.2 0.1 2.3 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF608 PF04685.13 EFE39441.1 - 0.15 11.2 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl-hydrolase family 116, catalytic region Ferric_reduct PF01794.19 EFE39442.1 - 2.4e-11 43.8 1.5 2.4e-11 43.8 1.5 2.5 3 0 0 3 3 3 1 Ferric reductase like transmembrane component DUF4405 PF14358.6 EFE39442.1 - 0.006 17.1 0.8 0.006 17.1 0.8 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4405) DUF2975 PF11188.8 EFE39442.1 - 0.12 12.2 0.0 0.12 12.2 0.0 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF2975) NAD_binding_6 PF08030.12 EFE39443.1 - 1.1e-20 74.4 0.0 4.3e-20 72.4 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFE39443.1 - 1.8e-11 44.1 0.1 6.2e-11 42.3 0.0 2.0 1 1 1 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 EFE39443.1 - 0.0025 18.4 0.0 3.1 8.5 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain Acetyltransf_7 PF13508.7 EFE39444.1 - 0.015 15.7 0.0 0.032 14.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE39444.1 - 0.078 13.2 0.0 0.93 9.7 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Sgf11 PF08209.11 EFE39445.1 - 1.2e-07 31.1 1.7 9.7e-07 28.2 0.1 2.5 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) Cytadhesin_P30 PF07271.11 EFE39446.1 - 0.26 10.8 0.0 19 4.7 0.0 2.1 2 0 0 2 2 2 0 Cytadhesin P30/P32 Tetraspanin PF00335.20 EFE39446.1 - 0.72 9.5 10.8 5.4 6.6 10.8 2.5 1 1 0 1 1 1 0 Tetraspanin family SRF-TF PF00319.18 EFE39447.1 - 4.2e-08 32.5 3.6 3.6e-07 29.5 1.2 2.2 1 1 1 2 2 2 2 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF3439 PF11921.8 EFE39447.1 - 0.014 15.3 3.5 0.03 14.3 3.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Spt20 PF12090.8 EFE39447.1 - 10 5.7 15.8 6.8 6.2 14.2 1.6 2 0 0 2 2 2 0 Spt20 family Lactonase PF10282.9 EFE39448.1 - 9.2e-86 288.2 0.0 1.1e-85 287.9 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller SoxE PF06525.11 EFE39448.1 - 0.078 12.5 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 Sulfocyanin (SoxE) domain Mg_trans_NIPA PF05653.14 EFE39449.1 - 6.4e-09 35.3 2.3 8.6e-09 34.9 2.3 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA TMEM61 PF15105.6 EFE39449.1 - 0.045 13.6 0.1 0.073 12.9 0.1 1.3 1 0 0 1 1 1 0 TMEM61 protein family EMP24_GP25L PF01105.24 EFE39449.1 - 0.31 11.0 0.4 0.47 10.4 0.4 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD vATP-synt_E PF01991.18 EFE39451.1 - 4.9e-59 199.1 11.3 5.6e-59 198.9 11.3 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4288 PF14119.6 EFE39451.1 - 0.0084 16.5 4.4 4.6 7.7 0.5 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4288) 4PPT_N PF17837.1 EFE39451.1 - 0.064 13.4 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase N-terminal domain IFS PF16718.5 EFE39451.1 - 0.065 13.3 0.5 0.33 11.0 0.5 1.9 2 0 0 2 2 2 0 Immunity factor for SPN PhoLip_ATPase_C PF16212.5 EFE39453.1 - 3.2e-79 266.2 19.1 3.2e-79 266.2 19.1 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFE39453.1 - 2.1e-19 69.0 1.8 5.2e-19 67.7 1.8 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFE39453.1 - 4.2e-12 46.0 0.0 2e-11 43.8 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFE39453.1 - 1.6e-10 41.6 0.2 1.2e-05 25.7 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFE39453.1 - 0.00011 21.8 0.1 0.00046 19.8 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFE39453.1 - 0.023 14.4 0.1 0.053 13.3 0.1 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SEN1_N PF12726.7 EFE39454.1 - 1.8e-206 687.8 6.5 2.5e-206 687.3 6.5 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 EFE39454.1 - 3.6e-72 243.3 3.5 3.6e-72 243.3 3.5 2.1 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 EFE39454.1 - 6e-60 202.3 0.0 1.5e-59 201.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFE39454.1 - 4.8e-09 36.2 0.1 1.8e-05 24.6 0.1 2.6 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 EFE39454.1 - 8.5e-08 32.1 0.4 5.7e-06 26.1 0.4 2.7 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 EFE39454.1 - 1.2e-07 31.7 0.1 0.014 15.1 0.0 3.6 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EFE39454.1 - 2.1e-07 31.4 0.0 1.2e-06 29.0 0.0 2.3 2 1 0 2 2 1 1 AAA domain DEAD PF00270.29 EFE39454.1 - 0.0019 18.0 0.1 0.0069 16.2 0.1 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-CCHC PF00098.23 EFE39454.1 - 0.0022 18.0 1.3 0.0022 18.0 1.3 3.6 3 0 0 3 3 2 2 Zinc knuckle ResIII PF04851.15 EFE39454.1 - 0.0063 16.5 0.0 0.042 13.8 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EFE39454.1 - 0.007 15.5 0.0 0.02 14.0 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EFE39454.1 - 0.067 13.5 0.0 1.4 9.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain Sigma70_r1_1 PF03979.14 EFE39454.1 - 0.13 12.4 0.8 0.6 10.2 0.8 2.2 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 zf-CCHC_5 PF14787.6 EFE39454.1 - 1.1 9.0 17.4 0.067 12.9 0.7 3.0 2 1 1 3 3 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 EFE39454.1 - 4.4 7.2 7.2 2.1 8.3 1.0 2.4 2 0 0 2 2 2 0 Zinc knuckle CAP59_mtransfer PF11735.8 EFE39455.1 - 2.3e-15 56.9 0.0 4.5e-15 56.0 0.0 1.4 2 0 0 2 2 2 1 Cryptococcal mannosyltransferase 1 CAP59_mtransfer PF11735.8 EFE39456.1 - 1.1e-38 133.3 2.5 1.3e-38 133.0 2.5 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 CorA PF01544.18 EFE39458.1 - 6.9e-09 35.4 0.0 1.3e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein ApoL PF05461.11 EFE39458.1 - 0.07 12.4 0.2 0.11 11.8 0.2 1.3 1 0 0 1 1 1 0 Apolipoprotein L WH1 PF00568.23 EFE39459.1 - 1.6e-28 98.8 0.0 2.4e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 EFE39459.1 - 0.0026 17.6 2.5 0.0038 17.0 0.1 2.5 2 0 0 2 2 2 1 WH2 motif eIF-1a PF01176.19 EFE39461.1 - 4.7e-22 77.6 0.0 6.5e-22 77.1 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 ERCC4 PF02732.15 EFE39462.1 - 1.1e-18 67.9 0.0 4.9e-18 65.8 0.0 2.2 2 0 0 2 2 2 1 ERCC4 domain HHH_5 PF14520.6 EFE39462.1 - 0.19 12.3 0.0 0.66 10.6 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain fn3_2 PF16893.5 EFE39463.1 - 8.1e-38 128.5 0.1 1.4e-37 127.7 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EFE39463.1 - 8.2e-18 64.1 3.2 2.3e-16 59.5 3.2 2.4 1 1 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 EFE39463.1 - 3.7e-14 52.4 0.0 6.6e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EFE39463.1 - 3.1e-07 30.7 0.0 5.8e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFE39463.1 - 2.5e-05 24.6 0.0 5.6e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain fn3 PF00041.21 EFE39463.1 - 0.0026 18.1 0.0 0.0088 16.4 0.0 1.9 1 1 0 1 1 1 1 Fibronectin type III domain DUF3006 PF11213.8 EFE39463.1 - 0.065 13.5 0.0 0.34 11.2 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3006) Peptidase_S10 PF00450.22 EFE39464.1 - 2.1e-75 254.7 0.0 3.3e-75 254.1 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Acetyltransf_7 PF13508.7 EFE39465.1 - 0.0044 17.4 0.0 0.0098 16.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE39465.1 - 0.034 14.2 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE39465.1 - 0.089 13.0 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_1 PF00583.25 EFE39466.1 - 1.1e-08 35.3 0.0 1.7e-08 34.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE39466.1 - 5.3e-08 32.9 0.0 1.6e-07 31.3 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE39466.1 - 6.2e-06 26.3 0.1 5.3e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE39466.1 - 1.4e-05 25.4 0.0 3.1e-05 24.3 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 EFE39466.1 - 0.005 17.0 0.0 0.02 15.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFE39466.1 - 0.099 12.8 0.0 0.24 11.6 0.0 1.6 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase GFA PF04828.14 EFE39467.1 - 5.7e-10 39.4 0.9 0.00037 20.8 0.1 2.3 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme MFS_1 PF07690.16 EFE39468.1 - 2.5e-47 161.6 36.4 2.5e-47 161.6 36.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE39468.1 - 3.4e-11 42.7 10.0 3.4e-11 42.7 10.0 2.7 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EFE39468.1 - 2.5e-06 26.2 1.9 2.5e-06 26.2 1.9 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) CAAD PF14159.6 EFE39468.1 - 0.048 13.5 0.0 0.29 11.0 0.0 2.4 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase DUF4614 PF15391.6 EFE39468.1 - 0.29 11.1 0.7 5 7.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) DUF2583 PF10762.9 EFE39468.1 - 3.5 8.1 7.0 0.29 11.6 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2583) MFS_1 PF07690.16 EFE39469.1 - 4.8e-18 65.2 59.9 1.1e-16 60.8 54.1 3.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE39469.1 - 1.6e-08 33.5 28.2 1.6e-07 30.2 15.7 2.1 1 1 1 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFE39469.1 - 6.8e-08 31.8 33.9 9.7e-06 24.7 15.0 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2417 PF10329.9 EFE39470.1 - 0.036 13.5 0.1 0.064 12.7 0.1 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) DUF2207 PF09972.9 EFE39470.1 - 0.51 9.0 5.3 0.75 8.5 5.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Evr1_Alr PF04777.13 EFE39471.1 - 6.3e-12 45.8 0.1 1.1e-11 45.0 0.1 1.4 1 1 0 1 1 1 1 Erv1 / Alr family R3H PF01424.22 EFE39473.1 - 1.4e-12 47.4 0.1 4.5e-12 45.8 0.1 1.9 2 0 0 2 2 2 1 R3H domain zf-NF-X1 PF01422.17 EFE39473.1 - 0.00016 21.6 53.0 0.00064 19.7 14.5 13.2 13 2 2 15 15 15 5 NF-X1 type zinc finger DUF4551 PF15087.6 EFE39473.1 - 0.31 9.8 8.3 0.62 8.8 8.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF5423 PF17461.2 EFE39473.1 - 2.3 7.0 8.7 2.5 6.9 6.8 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5423) Pkinase PF00069.25 EFE39474.1 - 0.015 14.7 0.4 0.042 13.2 0.4 1.7 1 1 1 2 2 2 0 Protein kinase domain ARID PF01388.21 EFE39475.1 - 1.9e-18 66.9 0.0 1.9e-18 66.9 0.0 2.3 2 1 0 2 2 2 1 ARID/BRIGHT DNA binding domain BAF250_C PF12031.8 EFE39475.1 - 0.4 9.9 0.0 0.4 9.9 0.0 2.7 3 0 0 3 3 3 0 SWI/SNF-like complex subunit BAF250/Osa Presenilin PF01080.17 EFE39475.1 - 0.75 8.5 22.9 0.18 10.6 13.5 2.4 2 0 0 2 2 2 0 Presenilin Img2 PF05046.14 EFE39476.1 - 4.3e-19 68.6 0.0 7.6e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) eIF3_N PF09440.10 EFE39477.1 - 2.5e-48 163.9 2.4 6.1e-48 162.6 2.4 1.7 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EFE39477.1 - 5.2e-14 52.6 0.0 1.6e-13 51.1 0.0 1.9 1 0 0 1 1 1 1 PCI domain DUF445 PF04286.12 EFE39477.1 - 3.2 7.5 7.6 1.3 8.8 2.6 2.6 2 2 1 3 3 3 0 Protein of unknown function (DUF445) ArsA_ATPase PF02374.15 EFE39478.1 - 2.7e-110 368.3 0.0 3.8e-110 367.9 0.0 1.1 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EFE39478.1 - 4.2e-13 49.6 0.2 9.7e-12 45.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 EFE39478.1 - 9.8e-13 48.3 0.0 4.8e-12 46.1 0.0 2.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EFE39478.1 - 1.3e-05 24.8 0.0 2.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 EFE39478.1 - 1.8e-05 24.3 0.8 0.00032 20.2 0.1 2.3 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 EFE39478.1 - 2.9e-05 23.8 0.2 0.0011 18.6 0.0 2.7 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EFE39478.1 - 0.0002 20.9 0.0 0.0005 19.6 0.0 1.6 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ PhoH PF02562.16 EFE39478.1 - 0.11 12.0 0.0 0.26 10.7 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein NB-ARC PF00931.22 EFE39478.1 - 0.14 11.3 0.0 0.34 10.1 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain APS_kinase PF01583.20 EFE39478.1 - 0.16 11.8 0.3 8.5 6.2 0.0 3.0 3 0 0 3 3 3 0 Adenylylsulphate kinase Pacs-1 PF10254.9 EFE39478.1 - 0.17 10.8 0.6 0.28 10.1 0.6 1.2 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Ferric_reduct PF01794.19 EFE39479.1 - 2.3e-17 63.3 15.2 3.8e-17 62.6 15.2 1.3 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFE39479.1 - 3.2e-17 63.1 0.0 4.8e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFE39479.1 - 3.8e-08 33.4 0.0 0.0073 16.4 0.0 2.5 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 EFE39479.1 - 0.035 14.7 0.0 4.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Transthyretin PF00576.21 EFE39480.1 - 6.9e-28 97.5 0.0 9.6e-28 97.1 0.0 1.2 1 0 0 1 1 1 1 HIUase/Transthyretin family Aft1_HRR PF11787.8 EFE39481.1 - 3.6e-19 69.7 2.4 3.6e-19 69.7 2.4 4.0 2 1 1 3 3 3 1 Aft1 HRR domain Aft1_HRA PF11786.8 EFE39481.1 - 5.2e-18 65.1 11.9 5.2e-18 65.1 11.9 3.2 2 1 1 3 3 3 1 Aft1 HRA domain Aft1_OSA PF11785.8 EFE39481.1 - 6.3e-15 55.3 7.9 9.3e-15 54.8 4.7 2.9 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 EFE39481.1 - 1.5e-08 34.6 10.2 2.5e-08 33.9 10.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EFE39481.1 - 0.0021 18.1 8.8 0.0043 17.1 8.8 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EFE39481.1 - 0.056 14.0 3.9 0.12 12.9 3.9 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor HeLo PF14479.6 EFE39481.1 - 0.11 12.3 0.8 0.18 11.6 0.8 1.4 1 0 0 1 1 1 0 Prion-inhibition and propagation Nop53 PF07767.11 EFE39481.1 - 0.17 11.2 14.1 0.25 10.7 14.1 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PARP PF00644.20 EFE39482.1 - 1.5e-11 44.3 0.2 3.3e-11 43.1 0.2 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.26 EFE39482.1 - 5.3e-08 32.6 0.0 1.1e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFE39482.1 - 0.034 14.4 0.0 0.36 11.1 0.0 2.4 2 0 0 2 2 2 0 RWD domain SPESP1 PF15754.5 EFE39483.1 - 0.2 10.8 2.0 0.28 10.3 1.5 1.5 1 1 0 1 1 1 0 Sperm equatorial segment protein 1 DASH_Spc19 PF08287.11 EFE39483.1 - 2.1 8.2 12.2 1.4 8.8 0.2 3.3 3 1 0 3 3 3 0 Spc19 RNA_pol_Rpb4 PF03874.16 EFE39484.1 - 2.1e-07 31.3 0.7 0.012 16.0 0.0 2.5 2 1 0 2 2 2 2 RNA polymerase Rpb4 Nop PF01798.18 EFE39485.1 - 4.2e-83 278.3 0.5 4.2e-83 278.3 0.5 1.9 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFE39485.1 - 3.1e-18 65.9 3.9 4.8e-12 46.1 0.3 4.2 4 1 1 5 5 5 2 NOP5NT (NUC127) domain Mitofilin PF09731.9 EFE39485.1 - 3.8 6.2 38.8 8.5 5.1 35.8 2.2 2 0 0 2 2 2 0 Mitochondrial inner membrane protein vATP-synt_AC39 PF01992.16 EFE39486.1 - 2.1e-80 270.8 0.1 2.7e-80 270.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Pribosyltran_N PF13793.6 EFE39487.1 - 1e-33 115.7 0.0 2.1e-33 114.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFE39487.1 - 4.8e-31 108.2 1.5 1.3e-28 100.3 1.5 2.4 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFE39487.1 - 2.9e-12 46.4 0.1 6.5e-12 45.3 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFE39487.1 - 0.004 16.6 0.0 0.0066 15.9 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase YukD PF08817.10 EFE39488.1 - 0.0026 18.4 0.0 0.004 17.8 0.0 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD ubiquitin PF00240.23 EFE39488.1 - 0.0057 16.4 0.0 0.0081 15.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family PseudoU_synth_1 PF01416.20 EFE39489.1 - 5.2e-35 120.2 0.0 1.9e-34 118.4 0.0 2.0 2 0 0 2 2 2 1 tRNA pseudouridine synthase Pox_A_type_inc PF04508.12 EFE39489.1 - 0.005 16.6 0.2 0.014 15.2 0.2 1.8 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat Amidoligase_2 PF12224.8 EFE39490.1 - 0.00013 21.7 0.1 0.0015 18.3 0.1 2.1 1 1 0 1 1 1 1 Putative amidoligase enzyme Ribosomal_S2 PF00318.20 EFE39491.1 - 5.1e-26 91.2 0.1 3e-14 52.8 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 EFE39491.1 - 3.2e-05 25.2 21.5 5.9e-05 24.3 21.5 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S15 PF00312.22 EFE39492.1 - 1.3e-24 86.1 1.7 3.5e-24 84.8 0.2 2.2 2 0 0 2 2 2 1 Ribosomal protein S15 Hanta_nucleocap PF00846.18 EFE39492.1 - 0.04 12.4 0.8 0.054 11.9 0.2 1.5 2 0 0 2 2 2 0 Hantavirus nucleocapsid protein ERM PF00769.19 EFE39493.1 - 0.00071 19.5 2.7 0.00071 19.5 2.7 3.1 3 1 0 3 3 3 1 Ezrin/radixin/moesin family DEAD PF00270.29 EFE39494.1 - 2.5e-32 112.1 0.0 1.6e-31 109.4 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE39494.1 - 3.6e-21 75.6 0.0 1.3e-20 73.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFE39494.1 - 3.3e-20 72.1 0.0 6.7e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) AAA_22 PF13401.6 EFE39494.1 - 0.057 13.7 0.3 0.86 9.9 0.3 2.5 1 1 0 1 1 1 0 AAA domain MCM_bind PF09739.9 EFE39494.1 - 9.4 4.5 8.7 13 4.1 8.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Kelch_4 PF13418.6 EFE39495.1 - 1.2e-11 44.4 24.7 4.8e-07 29.7 0.1 6.2 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFE39495.1 - 7.6e-09 35.4 4.2 0.23 11.5 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EFE39495.1 - 0.00043 20.5 12.4 0.00071 19.8 0.0 5.1 6 1 0 6 6 6 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFE39495.1 - 0.2 11.7 8.2 4.2 7.5 0.5 4.1 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 EFE39496.1 - 2.4e-05 25.0 0.3 0.04 14.8 0.0 4.7 4 1 1 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39496.1 - 0.00012 22.3 0.0 0.19 12.0 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 EFE39496.1 - 0.025 14.3 0.1 0.97 9.1 0.0 2.7 2 1 0 3 3 3 0 TUP1-like enhancer of split Ge1_WD40 PF16529.5 EFE39496.1 - 0.18 10.7 0.0 0.52 9.2 0.0 1.8 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein MFS_1 PF07690.16 EFE39497.1 - 3.9e-23 81.9 46.0 8.2e-19 67.7 23.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2914 PF11141.8 EFE39498.1 - 0.18 11.6 1.3 8.3 6.3 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2914) Met_10 PF02475.16 EFE39499.1 - 0.00016 21.5 0.0 0.00063 19.5 0.0 2.0 2 1 0 2 2 2 1 Met-10+ like-protein EF-hand_6 PF13405.6 EFE39500.1 - 5.7e-09 35.2 0.8 0.00021 20.9 0.1 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EFE39500.1 - 2.5e-05 24.6 0.5 0.00014 22.2 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EFE39500.1 - 0.0057 16.1 0.0 0.61 9.8 0.0 2.4 2 0 0 2 2 2 2 EF hand OB_NTP_bind PF07717.16 EFE39502.1 - 6.2e-21 74.6 0.0 1.7e-20 73.2 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EFE39502.1 - 5.8e-19 68.4 0.0 1.6e-18 66.9 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFE39502.1 - 3e-10 40.4 0.0 7.7e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE39502.1 - 3.7e-07 30.1 0.1 6.5e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFE39502.1 - 2.9e-05 24.4 0.0 9.9e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EFE39502.1 - 0.00027 20.6 0.1 0.00075 19.2 0.1 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EFE39502.1 - 0.0024 18.2 0.1 0.0049 17.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EFE39502.1 - 0.0025 17.8 0.1 0.0046 16.9 0.1 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_30 PF13604.6 EFE39502.1 - 0.0042 16.8 0.0 0.0071 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EFE39502.1 - 0.042 14.4 0.0 0.077 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFE39502.1 - 0.1 11.6 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 EFE39502.1 - 0.19 10.9 0.0 0.32 10.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PRMT5_TIM PF17285.2 EFE39503.1 - 1.1e-71 241.0 0.0 1.7e-71 240.4 0.0 1.3 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 EFE39503.1 - 2.4e-64 216.3 0.0 3.8e-64 215.7 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EFE39503.1 - 3.3e-54 183.4 0.2 7.7e-54 182.2 0.2 1.6 1 0 0 1 1 1 1 PRMT5 oligomerisation domain GDPD PF03009.17 EFE39504.1 - 9.5e-44 150.1 0.0 6.6e-43 147.3 0.0 2.2 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EFE39504.1 - 3.7e-25 88.3 0.2 2.4e-07 31.3 0.4 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE39504.1 - 1.1e-23 83.2 1.0 2.4e-08 34.4 0.1 4.7 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFE39504.1 - 8.4e-18 64.0 3.0 0.0015 18.8 0.0 5.9 4 1 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EFE39504.1 - 1.5e-14 53.9 0.1 4.5e-05 23.6 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE39504.1 - 5.3e-14 51.0 1.0 0.031 14.8 0.0 6.0 6 0 0 6 6 6 3 Ankyrin repeat SPX PF03105.19 EFE39504.1 - 4.9e-13 49.8 16.4 1.4e-06 28.5 0.5 3.9 4 1 1 5 5 5 3 SPX domain TAT_signal PF10518.9 EFE39504.1 - 0.041 13.7 0.1 0.84 9.6 0.1 2.5 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence Abhydrolase_3 PF07859.13 EFE39505.1 - 7.2e-60 202.4 0.1 9.5e-60 202.0 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFE39505.1 - 3.9e-06 26.5 0.0 0.0007 19.1 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EFE39505.1 - 2.1e-05 23.6 0.2 6e-05 22.1 0.2 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 EFE39505.1 - 0.0021 18.7 3.9 0.0072 16.9 4.7 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase_phd PF10503.9 EFE39505.1 - 0.013 15.0 0.1 0.025 14.0 0.1 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase Lyase_1 PF00206.20 EFE39506.1 - 6.6e-107 357.5 0.0 1e-106 356.9 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EFE39506.1 - 9.5e-21 74.0 0.0 2.2e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus Acetyltransf_1 PF00583.25 EFE39508.1 - 4.3e-09 36.6 0.1 7.6e-09 35.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFE39508.1 - 3.3e-06 27.4 0.2 5.6e-06 26.7 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFE39508.1 - 2.8e-05 24.1 0.0 7.5e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Ribosomal_S30 PF04758.14 EFE39509.1 - 1.4e-27 95.7 9.0 1.7e-27 95.4 9.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S30 Ribosomal_L24e PF01246.20 EFE39510.1 - 5e-29 100.3 1.6 5.1e-29 100.3 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e WD40 PF00400.32 EFE39511.1 - 4.5e-08 33.6 17.7 0.0043 17.9 0.0 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EFE39511.1 - 7.5e-08 31.9 16.9 4e-07 29.6 16.9 2.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RWD PF05773.22 EFE39511.1 - 0.0016 18.7 0.0 0.0045 17.3 0.0 1.7 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 EFE39511.1 - 0.0054 17.0 11.5 0.017 15.4 11.5 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFE39511.1 - 0.68 9.8 10.7 1.9 8.4 10.7 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) 4HBT PF03061.22 EFE39512.1 - 3.2e-06 27.4 0.0 4.6e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EFE39512.1 - 0.0044 17.2 0.0 0.0065 16.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) UCH PF00443.29 EFE39513.1 - 3.7e-48 164.3 7.7 5.6e-48 163.7 7.7 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE39513.1 - 7.3e-12 45.5 11.4 2.1e-11 44.0 11.4 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EFE39513.1 - 8.9e-11 41.4 0.0 2.1e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family RILP PF11461.8 EFE39513.1 - 0.24 11.6 0.0 0.24 11.6 0.0 3.2 3 1 0 3 3 3 0 Rab interacting lysosomal protein PTPRCAP PF15713.5 EFE39513.1 - 0.3 11.4 10.2 0.88 9.9 10.2 1.8 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF2992 PF11208.8 EFE39513.1 - 2.4 8.4 15.0 4.6 7.5 15.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) ARPC4 PF05856.12 EFE39514.1 - 2.5e-72 241.9 3.5 3e-72 241.7 3.5 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) TYW3 PF02676.14 EFE39516.1 - 6.2e-72 241.4 0.0 7.7e-72 241.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 DUF2461 PF09365.10 EFE39517.1 - 1.4e-17 64.4 1.0 2.7e-17 63.4 1.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) Polysacc_deac_1 PF01522.21 EFE39521.1 - 1.4e-18 67.0 0.2 6.1e-17 61.7 0.2 2.3 1 1 0 1 1 1 1 Polysaccharide deacetylase SOG2 PF10428.9 EFE39521.1 - 0.56 9.3 12.4 0.66 9.1 12.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Mito_carr PF00153.27 EFE39522.1 - 4.4e-47 158.0 0.4 9e-19 67.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 EFE39523.1 - 7.9e-15 55.0 11.1 5.9e-06 26.9 0.4 6.5 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39523.1 - 2.3e-06 27.8 0.0 1.1 9.7 0.0 4.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFE39523.1 - 0.0045 16.9 0.0 0.056 13.3 0.0 2.4 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Zn_ribbon_17 PF17120.5 EFE39523.1 - 0.0067 16.0 7.7 0.02 14.5 7.7 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type PD40 PF07676.12 EFE39523.1 - 0.055 13.4 1.0 0.33 10.9 0.1 2.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Forkhead PF00250.18 EFE39524.1 - 6.8e-20 71.1 0.2 1.4e-19 70.2 0.2 1.5 1 0 0 1 1 1 1 Forkhead domain Cactin_mid PF10312.9 EFE39525.1 - 5.2e-66 222.2 5.8 5.2e-66 222.2 5.8 1.6 2 0 0 2 2 2 1 Conserved mid region of cactin CactinC_cactus PF09732.9 EFE39525.1 - 6.7e-56 187.6 3.4 1.2e-55 186.8 3.4 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein XLF PF09302.11 EFE39526.1 - 2.3e-54 184.3 0.1 2.3e-54 184.3 0.1 2.3 3 0 0 3 3 3 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Ribosomal_L34e PF01199.18 EFE39527.1 - 5.1e-29 100.4 1.2 2.1e-16 60.0 0.1 2.3 1 1 1 2 2 2 2 Ribosomal protein L34e Vps36-NZF-N PF16988.5 EFE39527.1 - 0.012 15.0 1.0 0.022 14.2 0.0 1.9 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain FhuF_C PF11575.8 EFE39527.1 - 0.91 9.5 5.1 3.8 7.5 0.3 2.5 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain PROCN PF08083.11 EFE39528.1 - 7e-236 782.5 9.0 7e-236 782.5 9.0 2.0 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EFE39528.1 - 1.3e-126 420.9 2.6 2.2e-126 420.1 2.6 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EFE39528.1 - 5.5e-84 279.9 2.1 1.9e-57 193.7 0.3 3.1 2 0 0 2 2 2 2 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EFE39528.1 - 9.3e-81 269.2 1.8 2.6e-80 267.7 1.8 1.8 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EFE39528.1 - 1.5e-70 235.5 0.1 3.2e-70 234.4 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EFE39528.1 - 3.5e-48 161.9 0.3 9.5e-48 160.5 0.3 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EFE39528.1 - 9.4e-37 125.7 0.1 3.3e-36 123.9 0.1 1.9 1 0 0 1 1 1 1 PROCT (NUC072) domain Hom_end_hint PF05203.16 EFE39528.1 - 8e-08 32.5 2.1 8.7e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 Hom_end-associated Hint Hom_end PF05204.14 EFE39528.1 - 0.0071 16.5 0.0 0.024 14.8 0.0 1.9 1 0 0 1 1 1 1 Homing endonuclease CTP_synth_N PF06418.14 EFE39530.1 - 2e-66 224.0 0.0 2.6e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EFE39530.1 - 6.9e-56 189.0 0.0 1e-55 188.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFE39530.1 - 5.5e-06 26.3 0.4 7e-05 22.7 0.4 2.3 1 1 0 1 1 1 1 Peptidase C26 Myb_DNA-bind_6 PF13921.6 EFE39533.1 - 1.6e-07 31.5 0.0 3.3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFE39533.1 - 9.2e-05 22.6 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3678 PF12435.8 EFE39536.1 - 0.12 11.8 1.9 0.51 9.8 1.9 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) p450 PF00067.22 EFE39537.1 - 9.6e-54 182.8 0.7 1.2e-24 87.0 0.4 3.1 3 0 0 3 3 3 3 Cytochrome P450 FMO-like PF00743.19 EFE39538.1 - 8.6e-87 291.7 0.0 1e-86 291.5 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFE39538.1 - 7.6e-13 48.4 0.0 1.4e-09 37.6 0.0 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE39538.1 - 1.8e-09 37.2 0.1 2.9e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EFE39538.1 - 3.7e-08 33.0 0.0 3.8e-05 23.1 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase LeuA_dimer PF08502.10 EFE39538.1 - 0.042 13.8 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 LeuA allosteric (dimerisation) domain Pyr_redox PF00070.27 EFE39538.1 - 0.042 14.4 0.0 0.1 13.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SPX PF03105.19 EFE39540.1 - 0.025 14.5 3.3 0.053 13.4 3.3 1.6 1 0 0 1 1 1 0 SPX domain Forkhead PF00250.18 EFE39541.1 - 8.3e-34 115.7 1.6 1.6e-33 114.8 1.6 1.5 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EFE39541.1 - 2.5e-07 30.9 0.0 1.9e-06 28.2 0.0 2.2 2 0 0 2 2 2 1 FHA domain Linker_histone PF00538.19 EFE39541.1 - 0.012 15.9 0.2 0.027 14.8 0.2 1.5 1 0 0 1 1 1 0 linker histone H1 and H5 family E7 PF00527.18 EFE39542.1 - 0.12 12.6 0.8 0.11 12.7 0.8 1.0 1 0 0 1 1 1 0 E7 protein, Early protein MGTL PF17059.5 EFE39542.1 - 6.1 6.8 6.7 0.58 10.0 2.4 1.6 2 0 0 2 2 2 0 MgtA leader peptide FAD_binding_3 PF01494.19 EFE39543.1 - 6.9e-21 74.9 0.0 1e-20 74.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFE39543.1 - 4.8e-07 29.3 0.0 8.4e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFE39543.1 - 2.4e-06 27.7 2.2 7.4e-06 26.1 2.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFE39543.1 - 1.9e-05 24.0 7.1 2.5e-05 23.6 6.0 1.7 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EFE39543.1 - 3.4e-05 23.6 6.8 0.018 14.6 6.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EFE39543.1 - 0.00065 18.5 0.7 0.0059 15.4 2.4 1.6 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EFE39543.1 - 0.0016 17.6 2.9 0.0023 17.1 2.9 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFE39543.1 - 0.0021 17.5 5.0 0.0032 16.9 5.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFE39543.1 - 0.0035 17.9 1.5 0.029 14.9 2.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EFE39543.1 - 0.0049 16.0 0.0 0.0078 15.3 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase Thi4 PF01946.17 EFE39543.1 - 0.017 14.3 0.8 0.028 13.7 0.8 1.2 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 EFE39543.1 - 0.025 13.4 1.6 0.71 8.6 1.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Amino_oxidase PF01593.24 EFE39543.1 - 0.038 13.3 0.9 0.28 10.4 0.6 2.4 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Rossmann-like PF10727.9 EFE39543.1 - 0.04 13.8 0.3 0.13 12.1 0.1 1.9 2 0 0 2 2 2 0 Rossmann-like domain 3HCDH_N PF02737.18 EFE39543.1 - 0.14 12.1 3.2 0.23 11.3 3.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EFE39543.1 - 0.23 10.7 2.0 0.4 9.9 2.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EFE39543.1 - 0.23 11.0 0.9 0.87 9.1 0.9 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_3 PF13738.6 EFE39543.1 - 0.52 9.5 4.0 0.83 8.8 4.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Mac_assoc PF16628.5 EFE39544.1 - 7e-61 205.7 12.1 7e-61 205.7 12.1 3.3 2 1 0 2 2 2 1 Unstructured region on maltose acetyltransferase Hexapep PF00132.24 EFE39544.1 - 1e-11 44.0 6.2 1.1e-07 31.3 0.3 3.4 2 1 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Zn_clus PF00172.18 EFE39544.1 - 3.5e-10 39.8 8.8 6.1e-10 39.1 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mac PF12464.8 EFE39544.1 - 7.4e-10 38.9 0.0 1.6e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep_2 PF14602.6 EFE39544.1 - 1e-06 28.4 5.4 8.6e-06 25.4 0.4 2.8 2 1 1 3 3 3 1 Hexapeptide repeat of succinyl-transferase SUIM_assoc PF16619.5 EFE39544.1 - 0.0035 17.4 6.6 0.018 15.1 6.6 2.3 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 ALAD PF00490.21 EFE39545.1 - 8.3e-116 386.6 0.0 9.3e-116 386.4 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase p450 PF00067.22 EFE39546.1 - 2.8e-53 181.3 0.0 1.5e-43 149.3 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 Shugoshin_N PF07558.11 EFE39546.1 - 1.3e-18 66.6 2.0 3.7e-18 65.1 2.0 1.9 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 EFE39546.1 - 7.7e-10 38.4 8.1 7.7e-10 38.4 8.1 2.1 2 0 0 2 2 2 1 Shugoshin C terminus DAO PF01266.24 EFE39547.1 - 4e-16 59.6 0.4 1e-15 58.2 0.3 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EFE39547.1 - 1.2e-05 24.8 0.7 1.5e-05 24.5 0.7 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFE39547.1 - 4.4e-05 22.7 0.9 7.1e-05 22.1 0.9 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFE39547.1 - 0.00015 21.1 0.0 0.00022 20.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EFE39547.1 - 0.0011 18.8 0.1 0.0016 18.4 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EFE39547.1 - 0.0014 18.8 0.2 0.0029 17.8 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EFE39547.1 - 0.0019 17.4 0.1 0.0027 16.8 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 EFE39547.1 - 0.0031 16.3 0.3 0.0048 15.7 0.3 1.3 1 0 0 1 1 1 1 HI0933-like protein Methyltransf_34 PF11312.8 EFE39547.1 - 0.0054 16.0 0.0 0.0067 15.7 0.0 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Pyr_redox PF00070.27 EFE39547.1 - 0.027 15.0 0.2 0.027 15.0 0.2 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE39547.1 - 0.045 13.0 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFE39547.1 - 0.046 13.0 0.2 0.063 12.5 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EFE39547.1 - 0.093 11.8 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EFE39547.1 - 0.14 11.4 0.2 0.19 10.9 0.2 1.2 1 0 0 1 1 1 0 Thi4 family K_oxygenase PF13434.6 EFE39547.1 - 0.22 10.6 0.1 0.28 10.3 0.1 1.1 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) DAO_C PF16901.5 EFE39548.1 - 3.6e-43 146.4 0.1 5.8e-43 145.8 0.1 1.3 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase DAO PF01266.24 EFE39548.1 - 7.3e-31 108.0 0.0 1.1e-30 107.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase CCT PF06203.14 EFE39548.1 - 0.094 12.8 0.2 7.7 6.7 0.0 2.3 2 0 0 2 2 2 0 CCT motif SAM_2 PF07647.17 EFE39550.1 - 1.9e-10 40.7 0.1 3.5e-10 39.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFE39550.1 - 9.2e-08 32.4 1.0 1.6e-07 31.6 0.2 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 EFE39550.1 - 1.7e-07 31.7 0.3 7.3e-07 29.7 0.3 2.1 1 1 0 1 1 1 1 PH domain SAM_Ste50p PF09235.10 EFE39550.1 - 0.013 15.7 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Ste50p, sterile alpha motif SAM_PNT PF02198.16 EFE39550.1 - 0.019 15.0 0.1 0.05 13.6 0.1 1.8 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain PH_6 PF15406.6 EFE39550.1 - 0.064 13.5 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain SAM_3 PF18016.1 EFE39550.1 - 0.14 12.0 0.0 0.39 10.6 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) UQ_con PF00179.26 EFE39552.1 - 1.8e-43 147.6 0.0 2.2e-43 147.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EFE39552.1 - 3.9e-06 26.6 0.0 8.3e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 EFE39552.1 - 5.6e-05 22.9 0.0 0.00011 21.9 0.0 1.4 2 0 0 2 2 2 1 Prokaryotic E2 family B RWD PF05773.22 EFE39552.1 - 0.06 13.6 0.0 0.094 13.0 0.0 1.4 1 0 0 1 1 1 0 RWD domain APH PF01636.23 EFE39553.1 - 2.5e-09 37.4 0.0 2e-08 34.4 0.0 2.5 3 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 EFE39553.1 - 0.0018 17.7 0.0 0.0074 15.7 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain AAA PF00004.29 EFE39554.1 - 8e-41 139.6 0.0 1.5e-40 138.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE39554.1 - 1.2e-09 37.8 0.5 2.5e-09 36.8 0.5 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EFE39554.1 - 1.4e-09 37.7 0.1 2.7e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EFE39554.1 - 1.2e-05 25.5 0.0 2.6e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFE39554.1 - 1.8e-05 25.0 1.9 0.066 13.5 0.2 2.8 2 1 1 3 3 2 2 AAA domain DUF815 PF05673.13 EFE39554.1 - 5.2e-05 22.5 0.0 9.1e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EFE39554.1 - 9.7e-05 22.4 0.0 0.00028 20.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFE39554.1 - 0.0011 18.8 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFE39554.1 - 0.0013 19.2 0.5 0.029 14.7 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 EFE39554.1 - 0.0023 18.2 0.4 0.0062 16.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFE39554.1 - 0.014 15.1 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EFE39554.1 - 0.021 14.2 0.4 0.33 10.3 0.2 2.2 1 1 0 2 2 2 0 KaiC TIP49 PF06068.13 EFE39554.1 - 0.024 13.9 1.4 0.041 13.1 0.1 2.0 2 1 0 2 2 2 0 TIP49 P-loop domain AAA_18 PF13238.6 EFE39554.1 - 0.029 14.9 0.0 0.067 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EFE39554.1 - 0.045 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFE39554.1 - 0.046 13.6 0.7 1.3 8.9 0.2 2.8 2 1 0 3 3 3 0 NACHT domain AAA_33 PF13671.6 EFE39554.1 - 0.08 13.1 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EFE39554.1 - 0.092 12.2 1.2 0.91 8.9 0.1 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.6 EFE39554.1 - 0.092 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFE39554.1 - 0.096 12.4 3.9 0.41 10.3 0.5 2.5 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFE39554.1 - 0.098 13.1 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EFE39554.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_pol_Rpb1_5 PF04998.17 EFE39554.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.3 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 5 AAA_19 PF13245.6 EFE39554.1 - 0.13 12.6 0.4 0.36 11.2 0.4 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFE39554.1 - 0.14 11.5 0.1 0.28 10.5 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 EFE39554.1 - 0.15 11.7 0.7 0.82 9.4 0.0 2.4 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain AAA_30 PF13604.6 EFE39554.1 - 0.17 11.6 0.5 0.5 10.1 0.5 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFE39554.1 - 0.17 12.4 0.6 1.3 9.5 0.6 2.5 1 1 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 EFE39554.1 - 0.17 11.1 1.9 0.18 11.1 0.1 2.0 3 0 0 3 3 3 0 Zeta toxin WD40 PF00400.32 EFE39555.1 - 3.5e-13 49.8 14.5 0.0013 19.5 0.2 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39555.1 - 0.00061 20.0 0.0 2.4 8.5 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFE39555.1 - 0.19 11.6 0.0 2.7 7.8 0.0 2.7 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Mg_trans_NIPA PF05653.14 EFE39556.1 - 2.5e-63 213.9 14.2 8.1e-61 205.7 11.2 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EFE39556.1 - 0.00023 21.3 1.2 0.00023 21.3 1.2 3.8 3 1 0 3 3 3 1 EamA-like transporter family SLC35F PF06027.12 EFE39556.1 - 0.0025 17.4 5.2 0.004 16.7 4.5 1.5 1 1 0 1 1 1 1 Solute carrier family 35 Trp_oprn_chp PF09534.10 EFE39556.1 - 0.0099 15.7 0.5 1.1 9.0 0.6 2.7 3 0 0 3 3 3 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Ctr PF04145.15 EFE39556.1 - 0.11 13.1 0.0 25 5.4 0.0 3.1 2 1 0 2 2 2 0 Ctr copper transporter family DoxX_2 PF13564.6 EFE39556.1 - 0.31 11.2 8.2 1.7 8.8 0.9 2.8 2 1 1 3 3 3 0 DoxX-like family DUF2198 PF09964.9 EFE39556.1 - 0.48 10.5 5.9 0.14 12.3 1.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) bZIP_1 PF00170.21 EFE39557.1 - 0.72 10.0 9.6 1.7 8.8 4.6 2.6 2 0 0 2 2 2 0 bZIP transcription factor ABC_tran_CTD PF16326.5 EFE39557.1 - 8.6 6.7 10.1 0.87 9.9 5.0 2.1 2 0 0 2 2 2 0 ABC transporter C-terminal domain FlaC_arch PF05377.11 EFE39557.1 - 9.1 6.8 9.0 1.1 9.7 2.4 2.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) RRM_1 PF00076.22 EFE39558.1 - 2.6e-35 120.0 0.0 4.1e-17 61.7 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFE39558.1 - 9.4e-05 22.4 0.1 0.00068 19.7 0.0 2.2 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 EFE39558.1 - 0.00013 21.9 0.0 0.00089 19.2 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EFE39558.1 - 0.00077 19.5 0.2 0.029 14.5 0.0 2.5 2 1 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 EFE39558.1 - 0.0065 16.1 0.0 0.03 13.9 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFE39558.1 - 0.0093 15.8 0.0 0.031 14.1 0.0 1.7 2 0 0 2 2 2 1 Occluded RNA-recognition motif Statherin PF03875.13 EFE39558.1 - 2.4 8.3 9.3 1.3 9.2 6.8 2.0 2 0 0 2 2 2 0 Statherin AgrB PF04647.15 EFE39559.1 - 0.22 10.8 0.8 0.22 10.8 0.8 1.1 1 0 0 1 1 1 0 Accessory gene regulator B TIP_N PF12457.8 EFE39560.1 - 0.05 14.0 1.2 0.05 14.0 1.2 2.2 1 1 1 2 2 2 0 Tuftelin interacting protein N terminal LAM_C PF12544.8 EFE39561.1 - 0.12 12.6 0.1 0.71 10.0 0.0 2.0 2 0 0 2 2 2 0 Lysine-2,3-aminomutase His_Phos_1 PF00300.22 EFE39563.1 - 3.5e-12 46.4 0.0 2.1e-11 43.9 0.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Peptidase_M28 PF04389.17 EFE39564.1 - 1.8e-32 112.7 0.2 3e-32 111.9 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EFE39564.1 - 0.0019 18.0 0.2 0.0044 16.7 0.2 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 DUF1257 PF06868.11 EFE39564.1 - 0.11 12.7 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1257) GH3 PF03321.13 EFE39565.1 - 0.00058 18.8 0.0 0.00069 18.6 0.0 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter DnaJ PF00226.31 EFE39566.1 - 4.2e-21 74.8 1.0 8.8e-21 73.8 1.0 1.6 1 0 0 1 1 1 1 DnaJ domain PRP38_assoc PF12871.7 EFE39566.1 - 3.3e-05 24.4 32.8 3.3e-05 24.4 32.8 6.0 4 1 2 6 6 6 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term APH PF01636.23 EFE39570.1 - 5.6e-13 49.4 0.0 2.5e-12 47.3 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Avl9 PF09794.9 EFE39571.1 - 3.2e-39 134.7 0.0 4.5e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 EFE39571.1 - 0.0006 19.7 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Menin PF05053.13 EFE39571.1 - 6.9 4.9 12.5 9.3 4.5 12.5 1.1 1 0 0 1 1 1 0 Menin RPN2_C PF18004.1 EFE39571.1 - 7.1 6.5 9.2 0.24 11.3 0.8 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Cullin PF00888.22 EFE39572.1 - 2.7e-184 614.3 4.6 3.6e-184 613.9 4.6 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EFE39572.1 - 5.8e-27 93.5 4.6 6.1e-27 93.5 2.3 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain Cupin_1 PF00190.22 EFE39573.1 - 4.7e-10 39.3 0.1 6.9e-10 38.7 0.1 1.3 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EFE39573.1 - 2.1e-07 30.5 0.1 3.5e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 EFE39573.1 - 0.00041 20.1 0.1 0.00051 19.8 0.1 1.1 1 0 0 1 1 1 1 Cupin ARD PF03079.14 EFE39573.1 - 0.00084 19.6 0.0 0.0011 19.1 0.0 1.2 1 0 0 1 1 1 1 ARD/ARD' family AraC_binding PF02311.19 EFE39573.1 - 0.0036 17.2 0.0 0.0046 16.9 0.0 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 EFE39573.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) MARVEL PF01284.23 EFE39574.1 - 0.0036 17.3 2.4 0.0053 16.8 2.4 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF1418 PF07214.12 EFE39574.1 - 0.0091 15.8 0.9 0.08 12.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1418) HSP70 PF00012.20 EFE39576.1 - 4e-167 557.0 0.1 5.2e-167 556.6 0.1 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFE39576.1 - 4.4e-11 42.2 0.3 9.2e-11 41.1 0.0 1.6 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EFE39576.1 - 0.0037 17.7 0.1 0.47 10.9 0.0 3.1 2 1 0 2 2 2 1 Cell division protein FtsA Ketoacyl-synt_C PF02801.22 EFE39576.1 - 0.072 13.1 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EFE39577.1 - 1.2e-67 228.0 0.3 1.8e-67 227.5 0.3 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFE39577.1 - 3e-41 139.9 0.5 6.2e-41 138.9 0.5 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFE39577.1 - 0.052 13.1 1.2 0.13 11.8 1.2 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain SMG1 PF15785.5 EFE39577.1 - 0.097 11.0 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 WLM PF08325.10 EFE39578.1 - 9.3e-49 166.1 0.0 1.3e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.17 EFE39578.1 - 8.8e-05 22.6 0.1 0.00066 19.8 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function DUF45 SprT-like PF10263.9 EFE39578.1 - 0.044 13.6 0.1 0.096 12.6 0.1 1.5 1 0 0 1 1 1 0 SprT-like family LicD PF04991.13 EFE39579.1 - 1.5e-21 77.6 1.4 4.8e-17 62.9 1.2 2.1 1 1 1 2 2 2 2 LicD family DASH_Ask1 PF08655.10 EFE39581.1 - 1.3e-30 105.0 0.8 2.4e-30 104.2 0.8 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 Abhydrolase_1 PF00561.20 EFE39582.1 - 2.1e-19 70.2 0.1 1e-15 58.1 0.1 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE39582.1 - 3.2e-17 62.6 0.0 5.2e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFE39582.1 - 7.6e-16 59.4 0.1 8.5e-16 59.2 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 EFE39582.1 - 7.7e-06 24.8 0.0 9.6e-06 24.5 0.0 1.1 1 0 0 1 1 1 1 Ndr family Thioesterase PF00975.20 EFE39582.1 - 0.00039 20.6 0.0 0.00065 19.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EFE39582.1 - 0.02 14.6 1.3 0.74 9.5 1.3 2.3 1 1 0 1 1 1 0 PGAP1-like protein Palm_thioest PF02089.15 EFE39582.1 - 0.062 13.1 0.0 0.097 12.5 0.0 1.3 1 1 0 1 1 1 0 Palmitoyl protein thioesterase DUF915 PF06028.11 EFE39582.1 - 0.25 10.6 0.0 16 4.7 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) DUF4006 PF13179.6 EFE39584.1 - 0.025 14.5 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF4006) Amidohydro_1 PF01979.20 EFE39585.1 - 1e-18 67.8 2.1 1.6e-18 67.2 2.1 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFE39585.1 - 6.3e-14 52.3 4.5 3.5e-12 46.5 0.9 2.1 1 1 0 2 2 2 2 Amidohydrolase family tRNA-synt_1c PF00749.21 EFE39586.1 - 8.2e-99 330.4 0.0 1.1e-98 330.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFE39586.1 - 3.5e-38 131.2 1.5 5.3e-38 130.6 1.5 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.19 EFE39586.1 - 0.0069 15.8 0.0 0.025 13.9 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Glyco_hydro_3 PF00933.21 EFE39588.1 - 2.1e-82 277.1 0.0 2.9e-82 276.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_7 PF13508.7 EFE39588.1 - 8.6e-16 58.1 0.0 1.7e-06 28.3 0.0 2.6 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE39588.1 - 9.9e-15 54.8 0.1 1.2e-07 32.0 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE39588.1 - 3e-12 46.6 0.0 1.1e-05 25.4 0.0 2.9 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE39588.1 - 4.4e-06 26.8 0.1 0.005 16.9 0.1 2.7 2 1 0 2 2 2 2 Acetyltransferase (GNAT) domain Glyco_hydro_3_C PF01915.22 EFE39588.1 - 0.00027 21.0 0.1 0.0014 18.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_CG PF14542.6 EFE39588.1 - 0.00031 20.8 0.1 0.29 11.3 0.0 3.5 3 0 0 3 3 3 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFE39588.1 - 0.0008 19.3 0.1 0.048 13.6 0.1 2.6 2 0 0 2 2 2 1 FR47-like protein TrkA_N PF02254.18 EFE39588.1 - 0.14 12.4 0.2 0.42 10.9 0.2 1.8 1 0 0 1 1 1 0 TrkA-N domain ATP11 PF06644.11 EFE39589.1 - 4.1e-98 328.5 0.0 4.8e-98 328.3 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein Scytalone_dh PF02982.14 EFE39589.1 - 0.015 15.1 0.0 0.025 14.4 0.0 1.2 1 0 0 1 1 1 0 Scytalone dehydratase Hydrolase_4 PF12146.8 EFE39590.1 - 7.5e-15 54.9 0.0 3.2e-12 46.2 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFE39590.1 - 7.9e-10 38.8 0.0 4.7e-08 33.0 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE39590.1 - 1.9e-05 25.4 0.1 0.00015 22.5 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family BAAT_C PF08840.11 EFE39590.1 - 0.00032 20.7 0.0 0.009 15.9 0.0 2.3 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EFE39590.1 - 0.00055 19.6 0.0 0.4 10.2 0.0 2.6 3 0 0 3 3 3 2 Dienelactone hydrolase family FSH1 PF03959.13 EFE39590.1 - 0.0034 17.1 0.0 0.015 15.0 0.0 1.8 1 1 1 2 2 2 1 Serine hydrolase (FSH1) AXE1 PF05448.12 EFE39590.1 - 0.0036 16.0 0.1 0.05 12.3 0.1 2.4 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 EFE39590.1 - 0.0085 16.0 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EFE39590.1 - 0.019 14.5 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF818 PF05677.12 EFE39590.1 - 0.026 13.5 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) PGAP1 PF07819.13 EFE39590.1 - 0.034 13.9 0.2 0.44 10.2 0.2 2.1 1 1 0 1 1 1 0 PGAP1-like protein Peptidase_S9 PF00326.21 EFE39590.1 - 0.089 12.3 0.0 0.65 9.4 0.0 2.2 1 1 0 1 1 1 0 Prolyl oligopeptidase family Lipase_3 PF01764.25 EFE39590.1 - 0.17 11.8 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) 1-cysPrx_C PF10417.9 EFE39591.1 - 0.19 11.6 0.2 0.64 9.9 0.0 1.9 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin SAP PF02037.27 EFE39592.1 - 3.8e-12 45.6 0.6 6.6e-12 44.9 0.1 1.7 2 0 0 2 2 2 1 SAP domain Tho1_MOS11_C PF18592.1 EFE39592.1 - 3.7e-07 29.8 0.2 3.7e-07 29.8 0.2 2.4 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain CCT_2 PF09425.10 EFE39592.1 - 0.1 12.5 6.5 0.86 9.5 1.3 2.8 2 0 0 2 2 2 0 Divergent CCT motif SSrecog PF03531.14 EFE39593.1 - 3.5e-30 103.7 0.5 4.4e-29 100.2 0.0 3.0 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 EFE39593.1 - 1.7e-25 89.3 0.1 6.5e-25 87.4 0.0 2.0 2 0 0 2 2 2 1 Histone chaperone Rttp106-like POB3_N PF17292.2 EFE39593.1 - 1.9e-23 82.7 0.1 4.2e-22 78.4 0.0 2.6 2 0 0 2 2 2 1 POB3-like N-terminal PH domain Rax2 PF12768.7 EFE39594.1 - 4.8e-55 186.3 0.2 2.3e-42 144.9 0.0 3.7 2 1 1 3 3 3 2 Cortical protein marker for cell polarity Reg_prop PF07494.11 EFE39594.1 - 0.029 14.5 3.7 40 4.9 0.0 5.5 6 0 0 6 6 6 0 Two component regulator propeller Fungal_trans_2 PF11951.8 EFE39595.1 - 3.7e-06 26.0 4.0 8.8e-06 24.8 4.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain APH PF01636.23 EFE39596.1 - 6.8e-15 55.6 0.2 1.8e-14 54.3 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pyr_redox_3 PF13738.6 EFE39597.1 - 1.2e-10 41.2 0.4 2.5e-06 27.0 0.2 3.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EFE39597.1 - 3.7e-10 38.9 0.9 5.3e-09 35.0 0.4 2.4 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EFE39597.1 - 3.2e-09 36.4 0.0 0.00014 21.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFE39597.1 - 8.2e-09 35.6 0.2 2.1e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFE39597.1 - 5.6e-08 32.3 0.1 0.00024 20.4 0.0 3.2 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EFE39597.1 - 6.4e-08 32.6 0.0 0.0057 16.3 0.0 2.6 2 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFE39597.1 - 9.1e-05 22.5 0.0 0.25 11.3 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.17 EFE39597.1 - 0.00026 20.3 0.1 0.014 14.7 0.0 2.7 3 0 0 3 3 3 1 Thi4 family GIDA PF01134.22 EFE39597.1 - 0.013 14.7 0.2 0.12 11.5 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 EFE39597.1 - 0.14 10.8 0.2 12 4.5 0.0 2.8 3 0 0 3 3 3 0 HI0933-like protein OGG_N PF07934.12 EFE39598.1 - 2.8e-26 92.0 0.3 5.4e-26 91.0 0.3 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EFE39598.1 - 3.7e-16 59.5 0.0 6.5e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EFE39598.1 - 0.00038 20.2 0.0 0.00083 19.1 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif RRM_1 PF00076.22 EFE39599.1 - 1.4e-31 108.1 0.2 2.3e-13 49.7 0.0 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFE39599.1 - 1.6e-07 31.1 0.0 0.076 12.9 0.0 3.5 3 0 0 3 3 3 3 Occluded RNA-recognition motif zf-CCHC PF00098.23 EFE39600.1 - 4.2e-12 45.6 11.1 1.2e-05 25.2 3.6 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 EFE39600.1 - 1.2e-06 28.4 6.2 0.00079 19.3 2.9 2.3 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EFE39600.1 - 0.0002 21.0 4.7 0.16 11.7 0.4 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 EFE39600.1 - 0.0012 18.6 8.3 0.32 10.9 1.5 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 EFE39600.1 - 0.013 15.3 0.6 0.013 15.3 0.6 2.5 2 0 0 2 2 2 0 Zinc knuckle HCO3_cotransp PF00955.21 EFE39601.1 - 6.2e-76 256.2 12.7 1.9e-40 139.2 1.3 2.0 1 1 1 2 2 2 2 HCO3- transporter family BCHF PF07284.11 EFE39601.1 - 0.005 16.8 0.7 0.014 15.4 0.3 2.0 1 1 0 1 1 1 1 2-vinyl bacteriochlorophyllide hydratase (BCHF) DEAD PF00270.29 EFE39602.1 - 5.5e-41 140.3 0.0 1.3e-40 139.1 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE39602.1 - 4.6e-30 104.2 0.0 1e-29 103.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE39602.1 - 0.00013 22.0 0.0 0.00028 20.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EFE39602.1 - 0.012 14.3 0.0 0.021 13.5 0.0 1.4 1 0 0 1 1 1 0 SNF2 family N-terminal domain BRF1 PF07741.13 EFE39603.1 - 6.2 7.2 9.6 1.7 9.0 0.2 2.4 2 0 0 2 2 2 0 Brf1-like TBP-binding domain tRNA-synt_1c PF00749.21 EFE39606.1 - 1.9e-100 335.8 0.0 2.6e-100 335.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFE39606.1 - 1.2e-38 132.7 0.1 1.9e-38 132.0 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.6 EFE39606.1 - 0.00089 19.4 0.1 0.036 14.3 0.0 2.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFE39606.1 - 0.0053 17.0 0.0 0.015 15.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE39606.1 - 0.015 15.3 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1793 PF08760.11 EFE39607.1 - 5e-70 235.3 0.1 7.4e-70 234.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 EFE39607.1 - 5.1e-55 185.8 0.6 6.7e-48 162.6 0.0 3.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4965) DUF5127 PF17168.4 EFE39607.1 - 2.9e-07 30.5 0.4 4.8e-07 29.8 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5127) Stm1_N PF09598.10 EFE39610.1 - 3e-05 24.8 8.7 3e-05 24.8 8.7 4.5 4 2 0 4 4 4 1 Stm1 Glycos_transf_1 PF00534.20 EFE39613.1 - 7.5e-21 74.4 0.0 1.4e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFE39613.1 - 6e-13 49.4 0.0 1e-12 48.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EFE39613.1 - 0.00015 22.1 0.0 0.00052 20.3 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 CUTL PF16557.5 EFE39613.1 - 0.032 14.4 0.1 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 CUT1-like DNA-binding domain of SATB DUF3632 PF12311.8 EFE39615.1 - 8.3e-37 127.3 7.4 1.1e-36 126.9 7.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) RNA_pol_Rpb2_6 PF00562.28 EFE39616.1 - 3.2e-124 415.0 0.0 5.4e-124 414.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFE39616.1 - 4.9e-56 189.5 0.4 7.3e-56 188.9 0.4 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EFE39616.1 - 8.4e-31 106.2 0.4 2e-30 105.0 0.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 EFE39616.1 - 1.5e-29 103.0 1.8 3.6e-29 101.8 1.6 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EFE39616.1 - 9.3e-26 89.9 0.6 2.8e-25 88.4 0.6 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EFE39616.1 - 3.3e-18 65.6 0.0 7.6e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EFE39616.1 - 2e-11 44.3 0.5 6.9e-11 42.5 0.5 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ribosomal_L22e PF01776.17 EFE39616.1 - 0.18 12.2 0.9 1.1 9.7 0.0 2.4 2 0 0 2 2 2 0 Ribosomal L22e protein family PUF PF00806.19 EFE39617.1 - 3.7e-57 186.9 7.9 1.5e-07 30.7 0.0 9.0 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat ORC5_C PF14630.6 EFE39618.1 - 9.3e-77 258.3 0.0 1.3e-76 257.9 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EFE39618.1 - 6.4e-21 75.5 0.0 1.3e-20 74.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EFE39618.1 - 2.1e-06 27.8 0.1 0.034 14.1 0.0 2.6 3 0 0 3 3 2 2 NACHT domain ABC_tran PF00005.27 EFE39618.1 - 0.00044 20.8 0.0 0.00081 19.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 EFE39618.1 - 0.0023 18.2 0.0 0.0059 16.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EFE39618.1 - 0.0024 17.2 0.0 0.0034 16.7 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain T2SSE PF00437.20 EFE39618.1 - 0.0038 16.3 0.0 0.006 15.7 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EFE39618.1 - 0.0064 16.2 0.0 0.0095 15.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFE39618.1 - 0.013 15.3 0.0 0.034 13.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EFE39618.1 - 0.014 14.7 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_33 PF13671.6 EFE39618.1 - 0.018 15.2 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFE39618.1 - 0.026 15.0 0.0 0.047 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFE39618.1 - 0.044 13.8 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 EFE39618.1 - 0.048 13.2 1.1 9 5.8 0.1 2.5 3 0 0 3 3 2 0 AAA domain SMC_N PF02463.19 EFE39618.1 - 0.075 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain RNA_helicase PF00910.22 EFE39618.1 - 0.084 13.3 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase cobW PF02492.19 EFE39618.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 EFE39618.1 - 0.11 11.8 0.1 0.53 9.5 0.0 2.0 2 1 1 3 3 3 0 Septin Viral_helicase1 PF01443.18 EFE39618.1 - 0.11 12.2 0.1 0.22 11.2 0.1 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Guanylate_kin PF00625.21 EFE39618.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Guanylate kinase ATPase_2 PF01637.18 EFE39618.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EFE39618.1 - 0.17 11.0 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA PF00004.29 EFE39618.1 - 0.19 12.1 0.1 0.5 10.8 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFE39618.1 - 0.23 11.0 0.0 1.2 8.6 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region PH PF00169.29 EFE39619.1 - 4.4e-05 24.0 0.3 0.0001 22.8 0.3 1.6 1 0 0 1 1 1 1 PH domain Bacteriocin_IIc PF10439.9 EFE39619.1 - 3.1 8.0 6.3 8.5 6.6 0.2 3.1 3 0 0 3 3 3 0 Bacteriocin class II with double-glycine leader peptide F-box-like PF12937.7 EFE39620.1 - 4.7e-07 29.6 0.0 1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EFE39620.1 - 0.0027 18.1 2.4 45 4.6 0.2 4.8 4 1 1 5 5 5 1 Leucine Rich repeats (2 copies) F-box PF00646.33 EFE39620.1 - 0.043 13.7 1.3 1.3 9.0 0.2 3.2 2 1 0 2 2 2 0 F-box domain DUF1688 PF07958.11 EFE39621.1 - 1.6e-173 577.3 0.0 8.8e-164 545.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1688) TPR_2 PF07719.17 EFE39622.1 - 5.7e-06 26.1 0.0 0.57 10.4 0.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat UBA PF00627.31 EFE39622.1 - 0.00054 19.8 0.0 0.0014 18.5 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain TPR_1 PF00515.28 EFE39622.1 - 0.0034 17.1 0.0 3.7 7.5 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFE39622.1 - 0.023 15.0 0.0 0.44 10.9 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DnaJ PF00226.31 EFE39622.1 - 0.21 11.7 1.1 0.36 11.0 0.0 1.9 2 0 0 2 2 2 0 DnaJ domain Ank_5 PF13857.6 EFE39623.1 - 2e-17 63.0 4.4 2.9e-09 37.0 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFE39623.1 - 2e-13 50.7 0.6 7e-13 49.0 0.1 2.2 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE39623.1 - 1.1e-11 45.0 0.0 1.6e-06 28.5 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE39623.1 - 3.9e-08 32.9 0.6 0.036 14.6 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EFE39623.1 - 6.7e-07 29.5 1.2 0.07 13.6 0.1 3.6 3 1 0 3 3 3 2 Ankyrin repeat AMP-binding PF00501.28 EFE39624.1 - 2.3e-73 247.2 0.0 3.2e-73 246.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EFE39624.1 - 4.7e-32 111.3 0.0 6.9e-29 100.8 0.0 2.2 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EFE39624.1 - 1.4e-13 51.0 0.0 1.1e-10 41.7 0.0 3.3 3 0 0 3 3 3 2 Phosphopantetheine attachment site DegT_DnrJ_EryC1 PF01041.17 EFE39625.1 - 3.3e-53 181.3 0.0 7.8e-53 180.0 0.0 1.6 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GFO_IDH_MocA PF01408.22 EFE39625.1 - 1.8e-17 64.3 0.0 3.8e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EFE39625.1 - 0.00034 20.6 0.0 0.00076 19.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain CoA_binding PF02629.19 EFE39625.1 - 0.00063 20.4 0.0 0.0022 18.6 0.0 2.0 2 0 0 2 2 2 1 CoA binding domain Aminotran_5 PF00266.19 EFE39625.1 - 0.0011 18.0 0.0 0.0018 17.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFE39625.1 - 0.0018 17.6 0.0 0.0029 16.9 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EFE39625.1 - 0.0038 15.8 0.0 0.0061 15.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Semialdhyde_dh PF01118.24 EFE39625.1 - 0.009 16.4 0.0 0.018 15.5 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 5_nucleotid_C PF02872.18 EFE39627.1 - 6.9e-36 123.8 0.0 9.2e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain tRNA-synt_1e PF01406.19 EFE39628.1 - 9.4e-115 383.1 0.0 1.5e-114 382.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EFE39628.1 - 7.8e-06 24.9 0.4 0.067 11.9 0.2 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 EFE39628.1 - 0.00078 19.9 0.0 0.0023 18.3 0.0 1.8 1 0 0 1 1 1 1 DALR domain tRNA-synt_1f PF01921.18 EFE39628.1 - 0.044 12.7 0.0 0.86 8.5 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) GCD14 PF08704.10 EFE39629.1 - 7.7e-64 215.7 0.0 4.9e-62 209.8 0.0 2.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit ABC_membrane PF00664.23 EFE39630.1 - 2.3e-83 280.0 37.4 9.9e-47 159.9 13.8 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE39630.1 - 9.5e-70 233.4 0.0 2.8e-34 118.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFE39630.1 - 8.3e-14 51.6 1.8 0.0016 17.9 0.0 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFE39630.1 - 1.7e-08 34.1 0.4 0.0077 15.9 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFE39630.1 - 4e-08 33.8 0.8 0.0035 17.7 0.1 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 EFE39630.1 - 2.4e-06 27.5 0.0 0.051 13.3 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain DEAD PF00270.29 EFE39630.1 - 3.1e-06 27.1 0.0 0.0049 16.7 0.0 2.8 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_23 PF13476.6 EFE39630.1 - 3.3e-06 27.7 0.2 0.043 14.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EFE39630.1 - 3.9e-06 26.9 0.5 0.048 13.6 0.0 3.3 4 0 0 4 4 3 2 RsgA GTPase AAA_22 PF13401.6 EFE39630.1 - 7.6e-06 26.2 2.2 0.019 15.3 0.1 4.0 2 2 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 EFE39630.1 - 1.6e-05 23.9 3.0 0.0082 15.0 0.1 2.7 4 0 0 4 4 4 2 Predicted ATPase of the ABC class SbcCD_C PF13558.6 EFE39630.1 - 2.2e-05 24.6 2.4 0.19 12.0 0.3 3.5 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 EFE39630.1 - 0.00038 20.5 0.0 1.4 9.0 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 EFE39630.1 - 0.00043 20.2 0.3 0.36 10.6 0.0 3.2 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EFE39630.1 - 0.00084 19.5 0.6 0.84 9.7 0.2 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain Zeta_toxin PF06414.12 EFE39630.1 - 0.0034 16.7 0.0 0.75 9.0 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_30 PF13604.6 EFE39630.1 - 0.005 16.6 1.0 2.7 7.6 0.0 3.7 3 1 0 3 3 3 1 AAA domain FtsK_SpoIIIE PF01580.18 EFE39630.1 - 0.0066 15.8 0.2 0.23 10.8 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_25 PF13481.6 EFE39630.1 - 0.014 15.0 0.1 5.6 6.5 0.0 3.4 4 0 0 4 4 4 0 AAA domain AAA_7 PF12775.7 EFE39630.1 - 0.017 14.6 0.0 1.5 8.3 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 EFE39630.1 - 0.022 14.9 0.0 12 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EFE39630.1 - 0.023 13.9 0.0 0.52 9.4 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_5 PF07728.14 EFE39630.1 - 0.025 14.6 0.1 46 4.0 0.0 4.2 4 1 0 4 4 4 0 AAA domain (dynein-related subfamily) TMEM100 PF16311.5 EFE39630.1 - 0.028 14.0 0.0 0.086 12.4 0.0 1.8 1 0 0 1 1 1 0 Transmembrane protein 100 AAA_10 PF12846.7 EFE39630.1 - 0.046 12.6 0.0 8.1 5.2 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain AAA_18 PF13238.6 EFE39630.1 - 0.096 13.2 0.0 22 5.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EFE39630.1 - 6.2 6.8 7.8 25 4.9 0.2 3.7 5 0 0 5 5 5 0 Dynamin family adh_short PF00106.25 EFE39631.1 - 2.9e-25 88.9 0.1 1.3e-13 50.9 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFE39631.1 - 1.8e-14 53.9 0.0 4.5e-09 36.2 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase PQ-loop PF04193.14 EFE39632.1 - 1.9e-38 130.0 8.3 6.7e-19 67.4 2.6 2.7 2 0 0 2 2 2 2 PQ loop repeat NMN_transporter PF04973.12 EFE39632.1 - 6.2 6.7 11.3 0.22 11.4 2.9 2.5 3 1 0 3 3 3 0 Nicotinamide mononucleotide transporter SGS PF05002.15 EFE39633.1 - 2.8e-27 94.6 7.9 2.8e-27 94.6 7.9 2.4 2 1 0 2 2 2 1 SGS domain CS PF04969.16 EFE39633.1 - 3.8e-18 66.3 0.0 7.5e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 CS domain TPR_1 PF00515.28 EFE39633.1 - 5.2e-05 22.9 1.9 0.00038 20.2 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFE39633.1 - 0.0011 19.0 0.9 0.18 12.0 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE39633.1 - 0.04 13.6 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 TPR repeat CcmH PF03918.14 EFE39633.1 - 0.06 12.6 0.2 0.13 11.6 0.2 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein TPR_16 PF13432.6 EFE39633.1 - 0.079 13.6 0.3 0.93 10.2 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat GAGE PF05831.11 EFE39633.1 - 1 10.0 9.7 5.6 7.5 3.2 2.7 2 0 0 2 2 2 0 GAGE protein SQHop_cyclase_N PF13249.6 EFE39634.1 - 1e-43 149.6 0.9 4.6e-37 127.7 0.1 3.5 3 0 0 3 3 3 2 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EFE39634.1 - 5e-41 140.8 0.0 2.9e-39 135.1 0.0 2.5 2 1 1 3 3 3 1 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 EFE39634.1 - 5.1e-31 106.1 4.0 5.1e-10 38.9 0.0 5.3 6 0 0 6 6 6 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 EFE39634.1 - 1.1e-05 24.9 1.1 0.11 11.8 0.1 4.1 2 1 2 4 4 4 3 Pectic acid lyase TED_complement PF07678.14 EFE39634.1 - 0.005 15.9 0.1 0.044 12.8 0.2 2.3 2 1 0 2 2 2 1 A-macroglobulin TED domain Ank_2 PF12796.7 EFE39636.1 - 4e-32 110.6 8.3 1.5e-11 44.8 0.7 4.7 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE39636.1 - 3.9e-26 91.1 6.8 1.1e-09 38.6 0.3 6.8 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE39636.1 - 1.2e-23 80.6 10.9 2.7e-05 24.2 0.0 10.0 11 0 0 11 11 11 5 Ankyrin repeat Ank_5 PF13857.6 EFE39636.1 - 7.8e-23 80.2 2.3 2e-10 40.7 0.1 6.9 5 2 3 8 8 8 4 Ankyrin repeats (many copies) Ank PF00023.30 EFE39636.1 - 5.3e-19 67.7 12.9 5.9e-06 26.5 0.1 7.7 7 1 0 7 7 7 3 Ankyrin repeat F-box PF00646.33 EFE39636.1 - 0.00012 21.9 0.3 0.00025 20.8 0.3 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE39636.1 - 0.00022 21.1 0.1 0.00045 20.1 0.1 1.5 1 0 0 1 1 1 1 F-box-like Ras PF00071.22 EFE39637.1 - 9.6e-48 161.8 0.0 1.2e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE39637.1 - 1.4e-26 93.1 0.0 1.9e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE39637.1 - 1.9e-08 34.0 0.0 2.9e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFE39637.1 - 0.00022 20.8 0.0 0.0003 20.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Pkinase PF00069.25 EFE39638.1 - 9.6e-35 120.2 0.0 1.6e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39638.1 - 1.9e-23 83.1 0.0 3.2e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFE39638.1 - 0.014 14.8 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Macoilin PF09726.9 EFE39639.1 - 4.1 5.8 16.7 6.9 5.1 16.7 1.3 1 0 0 1 1 1 0 Macoilin family Sugar_tr PF00083.24 EFE39641.1 - 5.8e-19 68.3 6.6 7e-19 68.0 6.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter p53-inducible11 PF14936.6 EFE39641.1 - 0.054 13.5 0.1 0.093 12.8 0.1 1.5 1 0 0 1 1 1 0 Tumour protein p53-inducible protein 11 Sugar_tr PF00083.24 EFE39642.1 - 3.8e-40 138.1 8.3 4.6e-40 137.8 8.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE39642.1 - 9.9e-11 41.1 11.0 1.1e-10 40.9 11.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EFE39642.1 - 5.6e-05 21.6 3.7 7.4e-05 21.2 3.7 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Dynamin_N PF00350.23 EFE39643.1 - 1.3e-18 67.6 0.0 1.3e-17 64.4 0.0 2.6 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EFE39643.1 - 4.3e-08 33.2 0.2 1.1e-06 28.7 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFE39643.1 - 0.00011 22.7 0.0 0.00052 20.5 0.0 2.3 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.16 EFE39643.1 - 0.00063 19.1 0.1 0.032 13.5 0.1 2.9 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EFE39643.1 - 0.00081 19.3 0.9 0.003 17.5 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase IIGP PF05049.13 EFE39643.1 - 0.002 17.2 0.0 0.0071 15.5 0.0 1.9 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_16 PF13191.6 EFE39643.1 - 0.049 14.0 0.0 0.2 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.18 EFE39643.1 - 0.096 12.2 0.1 1.4 8.4 0.1 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF5089 PF17002.5 EFE39643.1 - 0.1 12.4 4.5 0.28 11.0 4.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) MeaB PF03308.16 EFE39643.1 - 0.12 11.4 0.1 0.21 10.6 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 EFE39643.1 - 0.16 11.8 0.1 0.31 10.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain CP12 PF02672.15 EFE39643.1 - 0.96 10.2 3.9 35 5.2 0.1 3.5 3 0 0 3 3 3 0 CP12 domain DUF1664 PF07889.12 EFE39643.1 - 8.7 6.4 9.9 4.5 7.3 0.4 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) CelTOS PF18659.1 EFE39644.1 - 0.027 14.9 0.2 0.037 14.5 0.2 1.2 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites DUF4718 PF15842.5 EFE39644.1 - 0.16 11.7 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) DUF4451 PF14616.6 EFE39645.1 - 5.8e-22 78.2 0.1 1.1e-21 77.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) Ribosomal_L24e PF01246.20 EFE39648.1 - 1.2e-30 105.5 5.5 3.9e-30 103.9 5.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e DUF4820 PF16091.5 EFE39648.1 - 0.029 13.8 3.8 0.039 13.3 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF4192 PF13830.6 EFE39648.1 - 0.072 13.1 0.6 0.08 13.0 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) Pam16 PF03656.13 EFE39649.1 - 5e-06 26.6 0.2 1.1e-05 25.5 0.2 1.6 1 1 0 1 1 1 1 Pam16 DnaJ PF00226.31 EFE39649.1 - 0.0004 20.5 0.0 0.00061 19.9 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF3918 PF13056.6 EFE39649.1 - 0.0017 17.9 0.9 0.0017 17.9 0.9 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF3918) Pkinase PF00069.25 EFE39650.1 - 6.8e-61 205.9 0.0 1.2e-59 201.9 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39650.1 - 8.1e-28 97.4 0.0 7.7e-27 94.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFE39650.1 - 0.0091 15.0 0.1 0.025 13.5 0.0 1.8 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EFE39650.1 - 0.037 13.4 0.1 0.086 12.2 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE39650.1 - 0.19 11.6 0.0 0.19 11.6 0.0 2.5 3 1 0 3 3 3 0 Phosphotransferase enzyme family Mito_fiss_reg PF05308.11 EFE39651.1 - 0.11 12.5 2.5 0.12 12.5 2.5 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 EFE39651.1 - 2.2 7.7 4.8 2.3 7.6 4.8 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal MFS_1 PF07690.16 EFE39652.1 - 9.6e-27 93.8 2.1 1.1e-26 93.6 2.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE39652.1 - 6e-08 32.0 6.3 1e-07 31.2 6.3 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 EFE39652.1 - 0.00048 19.1 1.4 0.0022 16.9 1.3 2.1 1 1 0 1 1 1 1 MFS_1 like family MFS_2 PF13347.6 EFE39652.1 - 0.004 15.8 1.0 0.0065 15.1 1.0 1.4 1 0 0 1 1 1 1 MFS/sugar transport protein ATG22 PF11700.8 EFE39652.1 - 0.0079 14.9 3.4 0.028 13.1 1.6 2.4 2 1 0 2 2 2 1 Vacuole effluxer Atg22 like TRI12 PF06609.13 EFE39652.1 - 0.0093 14.4 0.9 0.012 14.0 0.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EFE39652.1 - 0.014 13.9 1.1 0.02 13.3 1.1 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector MFS_4 PF06779.14 EFE39652.1 - 0.048 13.0 1.4 0.088 12.1 1.4 1.4 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB Terpene_synth_C PF03936.16 EFE39654.1 - 0.064 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain Rsbr_N PF08678.10 EFE39654.1 - 0.13 12.4 0.1 0.38 10.8 0.0 1.7 2 0 0 2 2 2 0 Rsbr N terminal AMP-binding PF00501.28 EFE39655.1 - 1e-72 245.1 0.0 1.9e-72 244.2 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EFE39655.1 - 1.9e-51 175.2 0.0 3.5e-32 111.7 0.0 4.4 3 1 0 3 3 3 2 Condensation domain PP-binding PF00550.25 EFE39655.1 - 2.5e-27 95.0 0.6 4e-12 46.3 0.0 3.0 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE39655.1 - 0.0012 19.8 0.1 0.0035 18.3 0.1 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ribonuclease PF00545.20 EFE39656.1 - 1e-06 29.4 0.0 1.6e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 ribonuclease DIM PF08194.12 EFE39656.1 - 0.35 11.1 5.4 3 8.1 0.2 2.4 2 0 0 2 2 2 0 DIM protein WD40 PF00400.32 EFE39657.1 - 1.2e-45 152.5 33.4 2.3e-05 25.0 0.1 12.2 11 1 0 11 11 11 9 WD domain, G-beta repeat Utp12 PF04003.12 EFE39657.1 - 2.9e-22 79.0 0.0 7.2e-22 77.7 0.0 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EFE39657.1 - 3.6e-20 72.1 7.4 0.0027 18.0 0.0 9.9 5 2 4 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE39657.1 - 5.2e-08 32.2 1.3 0.22 10.4 0.5 4.7 4 1 1 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFE39657.1 - 1.1e-05 25.0 0.0 0.2 10.9 0.0 3.5 3 0 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 EFE39657.1 - 3.4e-05 22.7 1.0 0.52 8.9 0.0 4.7 5 1 0 5 5 5 2 Nucleoporin Nup120/160 Frtz PF11768.8 EFE39657.1 - 0.00075 17.9 0.0 0.074 11.4 0.0 2.5 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz WD40_3 PF15911.5 EFE39657.1 - 0.094 12.7 0.0 2.5 8.2 0.0 2.8 3 0 0 3 3 3 0 WD domain, G-beta repeat Utp13 PF08625.11 EFE39657.1 - 0.14 12.1 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain P34-Arc PF04045.14 EFE39658.1 - 1.4e-48 165.7 0.0 1.8e-48 165.3 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc DUF2158 PF09926.9 EFE39658.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized small protein (DUF2158) DUF4294 PF14127.6 EFE39659.1 - 0.0038 17.2 0.0 0.0066 16.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4294) CCER1 PF15482.6 EFE39659.1 - 0.059 13.3 1.9 0.096 12.6 1.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 PP2C PF00481.21 EFE39660.1 - 6.9e-05 22.6 0.0 0.36 10.4 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EFE39660.1 - 0.0027 17.7 0.1 0.01 15.7 0.1 1.9 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EFE39660.1 - 0.0054 16.4 0.0 0.0076 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C CRM1_C PF08767.11 EFE39661.1 - 1.2e-130 435.3 7.6 1.2e-130 435.3 7.6 3.2 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 EFE39661.1 - 1.7e-41 141.8 10.9 1.8e-41 141.7 6.6 3.3 3 1 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EFE39661.1 - 7.2e-34 115.3 4.1 4.6e-33 112.7 4.1 2.5 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EFE39661.1 - 2.2e-29 101.3 3.8 2.7e-29 101.0 0.7 2.9 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EFE39661.1 - 5.8e-20 70.5 1.3 1.4e-19 69.3 1.3 1.7 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EFE39661.1 - 7e-10 38.7 0.1 2.7e-09 36.8 0.1 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF3385 PF11865.8 EFE39661.1 - 0.0048 16.8 0.2 0.5 10.3 0.0 3.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3385) HD_assoc PF13286.6 EFE39661.1 - 0.023 15.2 3.7 9 6.9 0.0 4.1 4 0 0 4 4 4 0 Phosphohydrolase-associated domain Pre-PUA PF17832.1 EFE39661.1 - 0.15 12.8 0.1 1.2 9.9 0.0 2.6 2 0 0 2 2 2 0 Pre-PUA-like domain DRE2_N PF16803.5 EFE39662.1 - 4.9e-33 114.2 0.1 1.1e-32 113.1 0.0 1.5 2 0 0 2 2 2 1 Fe-S cluster assembly protein DRE2 N-terminus CIAPIN1 PF05093.13 EFE39662.1 - 1.2e-28 99.5 0.8 3.3e-28 98.1 0.2 1.9 2 0 0 2 2 2 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Rft-1 PF04506.13 EFE39663.1 - 1.3e-129 433.3 13.4 1.5e-129 433.0 13.4 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt_3 PF13440.6 EFE39663.1 - 0.014 14.6 19.0 0.11 11.7 6.5 3.2 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein Polysacc_synt PF01943.17 EFE39663.1 - 0.019 14.3 25.9 0.017 14.5 14.8 3.1 2 1 0 2 2 2 0 Polysaccharide biosynthesis protein Aminotran_1_2 PF00155.21 EFE39664.1 - 8.3e-43 146.9 0.0 1.1e-42 146.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFE39664.1 - 4.6e-07 28.7 0.0 6.9e-07 28.1 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFE39664.1 - 1.5e-06 27.5 0.0 2.3e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFE39664.1 - 1.7e-06 27.5 0.0 3.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EFE39664.1 - 0.018 14.4 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family ABC2_membrane PF01061.24 EFE39665.1 - 3.3e-39 134.5 18.7 5.5e-39 133.8 18.7 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFE39665.1 - 1.1e-26 93.9 0.1 2.2e-26 93.0 0.1 1.5 1 0 0 1 1 1 1 ABC transporter EGF_2 PF07974.13 EFE39665.1 - 1.5e-06 28.5 23.6 9.9e-05 22.6 11.8 3.2 2 0 0 2 2 2 2 EGF-like domain AAA_21 PF13304.6 EFE39665.1 - 4.5e-06 26.7 0.0 0.06 13.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFE39665.1 - 0.0015 17.8 27.3 0.031 13.4 27.6 2.9 2 1 0 2 2 2 1 ABC-2 family transporter protein AAA_29 PF13555.6 EFE39665.1 - 0.0069 16.1 0.2 0.018 14.8 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EFE39665.1 - 0.016 15.8 0.1 0.037 14.5 0.1 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFE39665.1 - 0.02 14.8 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 EFE39665.1 - 0.024 14.8 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 EFE39665.1 - 0.027 13.9 0.1 0.12 11.8 0.1 1.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 EFE39665.1 - 0.033 14.7 0.0 0.11 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFE39665.1 - 0.034 14.4 0.0 0.092 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFE39665.1 - 0.045 13.3 0.0 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFE39665.1 - 0.072 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 EFE39665.1 - 0.085 12.4 0.1 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP-synt_ab PF00006.25 EFE39665.1 - 0.12 12.0 0.2 0.23 11.1 0.0 1.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.6 EFE39665.1 - 0.19 12.0 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 EFE39666.1 - 1.5e-18 66.8 33.9 1.5e-18 66.8 33.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Cornichon PF03311.14 EFE39667.1 - 1.4e-19 70.7 0.9 1.6e-19 70.5 0.9 1.3 1 0 0 1 1 1 1 Cornichon protein PSP1 PF04468.12 EFE39668.1 - 1.4e-28 98.9 2.6 2.4e-28 98.3 2.6 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DUF2570 PF10828.8 EFE39668.1 - 4.9 7.0 5.6 2.2 8.2 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) NifU PF01106.17 EFE39669.1 - 1e-27 96.1 0.2 2.2e-27 95.0 0.1 1.6 2 0 0 2 2 2 1 NifU-like domain Nfu_N PF08712.11 EFE39669.1 - 2.6e-25 88.3 0.0 8.7e-25 86.6 0.0 1.9 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal RasGEF PF00617.19 EFE39670.1 - 3.1e-41 141.5 0.3 8.9e-41 140.0 0.3 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFE39670.1 - 2.2e-13 50.4 0.0 5.5e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif AAA_16 PF13191.6 EFE39672.1 - 0.024 15.0 0.0 0.039 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 EFE39672.1 - 0.063 12.5 0.0 0.09 12.0 0.0 1.2 1 0 0 1 1 1 0 Septin Spore_IV_A PF09547.10 EFE39672.1 - 0.11 11.4 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) DUF5421 PF17458.2 EFE39672.1 - 0.13 11.7 0.1 0.16 11.3 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5421) AAA_24 PF13479.6 EFE39672.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFE39672.1 - 0.17 11.7 0.1 0.25 11.1 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF815 PF05673.13 EFE39672.1 - 0.21 10.7 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Uso1_p115_C PF04871.13 EFE39673.1 - 0.0081 16.5 17.0 0.014 15.8 17.0 1.4 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2721 PF11026.8 EFE39673.1 - 0.15 12.0 0.0 0.48 10.3 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) EcsB PF05975.12 EFE39673.1 - 0.2 10.5 0.6 0.33 9.8 0.6 1.2 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB Rgp1 PF08737.10 EFE39673.1 - 0.31 10.2 7.1 0.35 10.0 7.1 1.2 1 0 0 1 1 1 0 Rgp1 DUF2052 PF09747.9 EFE39673.1 - 0.34 11.0 19.9 0.016 15.3 13.0 1.9 1 1 1 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DRY_EERY PF09750.9 EFE39673.1 - 1.8 8.8 15.3 3.5 7.9 15.3 1.5 1 0 0 1 1 1 0 Alternative splicing regulator DUF4366 PF14283.6 EFE39673.1 - 4.2 7.4 8.0 0.42 10.7 1.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) AFT PF08731.11 EFE39674.1 - 1.4 9.3 4.5 0.62 10.5 1.8 1.7 1 1 1 2 2 2 0 Transcription factor AFT TMEM100 PF16311.5 EFE39674.1 - 5.1 6.7 6.4 6.9 6.3 2.0 2.3 1 1 1 2 2 2 0 Transmembrane protein 100 Cyclin_N PF00134.23 EFE39675.1 - 2.2e-11 43.6 0.0 4.2e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EFE39675.1 - 4.6e-05 23.8 0.0 9.6e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Cyclin AAA PF00004.29 EFE39676.1 - 3.5e-45 153.7 0.1 1.1e-44 152.0 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFE39676.1 - 4.2e-10 39.4 0.1 2.6e-09 36.9 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EFE39676.1 - 2e-09 37.6 0.5 3e-08 33.7 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFE39676.1 - 6.8e-08 32.8 0.0 1.4e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFE39676.1 - 2.9e-07 31.0 0.6 0.00013 22.4 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 EFE39676.1 - 1.2e-05 24.6 0.0 3.1e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EFE39676.1 - 3.8e-05 24.0 3.3 0.012 15.9 0.1 3.3 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 EFE39676.1 - 0.00014 21.6 0.0 0.001 18.8 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 EFE39676.1 - 0.0004 20.1 0.0 0.0011 18.8 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_7 PF12775.7 EFE39676.1 - 0.00043 19.9 0.0 0.0039 16.7 0.1 2.4 2 1 0 2 2 2 1 P-loop containing dynein motor region AAA_28 PF13521.6 EFE39676.1 - 0.00049 20.4 0.0 0.0021 18.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFE39676.1 - 0.00081 19.9 0.0 0.002 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFE39676.1 - 0.00087 19.3 0.1 0.0074 16.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFE39676.1 - 0.0023 18.3 0.0 0.0052 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TsaE PF02367.17 EFE39676.1 - 0.0032 17.5 0.0 0.02 14.9 0.0 2.1 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 EFE39676.1 - 0.0045 16.9 0.0 0.02 14.8 0.0 2.0 2 0 0 2 2 2 1 NTPase AAA_3 PF07726.11 EFE39676.1 - 0.0076 16.1 0.0 0.022 14.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFE39676.1 - 0.009 15.4 0.0 0.023 14.1 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFE39676.1 - 0.0097 16.1 0.0 0.025 14.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EFE39676.1 - 0.01 15.1 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain NACHT PF05729.12 EFE39676.1 - 0.012 15.6 0.7 0.14 12.1 0.0 2.8 3 0 0 3 3 2 0 NACHT domain AAA_30 PF13604.6 EFE39676.1 - 0.012 15.4 0.1 0.026 14.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFE39676.1 - 0.014 15.1 0.0 0.03 14.1 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein TniB PF05621.11 EFE39676.1 - 0.021 14.2 0.1 0.91 8.9 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein ATPase_2 PF01637.18 EFE39676.1 - 0.027 14.4 0.1 0.3 11.0 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EFE39676.1 - 0.029 14.1 0.2 0.069 12.9 0.2 1.7 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EFE39676.1 - 0.051 12.9 0.1 0.76 9.1 0.0 2.2 2 0 0 2 2 2 0 KaiC Bac_DnaA PF00308.18 EFE39676.1 - 0.061 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein Zeta_toxin PF06414.12 EFE39676.1 - 0.094 12.0 0.0 0.24 10.7 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 EFE39676.1 - 0.097 12.4 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFE39676.1 - 0.1 12.1 1.1 0.34 10.5 0.1 2.1 2 1 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 EFE39676.1 - 0.12 12.1 0.2 1.5 8.5 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain USP8_dimer PF08969.11 EFE39676.1 - 0.16 12.2 1.3 0.29 11.3 0.4 2.0 2 0 0 2 2 1 0 USP8 dimerisation domain AAA_19 PF13245.6 EFE39676.1 - 0.17 12.2 0.1 0.46 10.8 0.1 1.7 1 0 0 1 1 1 0 AAA domain RAG2 PF03089.14 EFE39676.1 - 0.18 10.7 0.0 0.29 10.1 0.0 1.2 1 0 0 1 1 1 0 Recombination activating protein 2 Asp PF00026.23 EFE39677.1 - 6.8e-109 364.1 0.8 8.2e-109 363.8 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFE39677.1 - 1.4e-15 58.0 2.9 3.3e-09 37.2 0.4 2.7 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFE39677.1 - 2.9e-06 27.8 0.4 0.069 13.8 0.0 3.7 3 2 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 EFE39677.1 - 0.00093 19.7 0.1 3.1 8.4 0.0 3.3 3 2 0 3 3 3 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EFE39677.1 - 0.0076 16.0 0.0 0.082 12.7 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gp45-slide_C PF09116.10 EFE39677.1 - 0.05 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 gp45 sliding clamp, C terminal NIF PF03031.18 EFE39678.1 - 2.5e-27 95.6 0.0 4.9e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EFE39678.1 - 1.5e-09 38.1 0.0 5.5e-09 36.3 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFE39678.1 - 1.9e-07 31.4 0.1 3.3e-05 24.2 0.0 2.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EFE39678.1 - 1.3e-05 25.0 0.2 3.1e-05 23.8 0.2 1.6 1 0 0 1 1 1 1 twin BRCT domain Biotin_lipoyl_2 PF13533.6 EFE39678.1 - 0.00064 19.5 0.0 1.2 9.1 0.0 2.7 2 0 0 2 2 2 2 Biotin-lipoyl like RTT107_BRCT_5 PF16770.5 EFE39678.1 - 0.0092 15.9 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EFE39678.1 - 0.02 15.0 0.1 0.05 13.7 0.1 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain MARVEL PF01284.23 EFE39680.1 - 0.00055 20.0 8.3 0.00098 19.2 8.3 1.4 1 1 0 1 1 1 1 Membrane-associating domain Arginase PF00491.21 EFE39682.1 - 1.8e-75 254.0 0.4 2.3e-75 253.7 0.4 1.1 1 0 0 1 1 1 1 Arginase family GatB_N PF02934.15 EFE39683.1 - 5.4e-57 193.3 0.0 7.5e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EFE39683.1 - 6.7e-24 84.4 0.0 1.2e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 GatB domain GatB_N PF02934.15 EFE39684.1 - 0.00012 21.6 0.1 0.00016 21.2 0.1 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain TraG_N PF07916.11 EFE39685.1 - 0.075 11.9 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region TPR_1 PF00515.28 EFE39687.1 - 1.5e-49 163.9 31.2 7.6e-08 31.9 0.1 11.3 10 2 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 EFE39687.1 - 4.1e-45 148.3 22.5 8.8e-06 25.5 0.0 11.3 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 EFE39687.1 - 9e-37 122.2 18.8 6.7e-07 29.0 0.0 10.9 10 1 0 10 10 10 7 Tetratricopeptide repeat TPR_17 PF13431.6 EFE39687.1 - 1.4e-21 75.2 31.5 0.00013 22.0 0.2 10.3 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFE39687.1 - 5.3e-21 75.0 31.1 1.8e-05 25.3 0.0 7.4 7 1 0 8 8 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFE39687.1 - 4.6e-20 71.0 27.3 5.8e-05 22.7 1.5 9.0 5 2 4 9 9 9 6 TPR repeat TPR_19 PF14559.6 EFE39687.1 - 5.9e-18 65.1 34.6 2.4e-05 24.7 0.5 7.6 6 2 2 8 8 7 5 Tetratricopeptide repeat TPR_6 PF13174.6 EFE39687.1 - 3.6e-17 61.8 32.3 0.0037 17.8 0.0 10.9 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFE39687.1 - 1.9e-16 59.3 38.2 6.7e-05 23.4 0.1 11.0 5 2 8 13 13 11 6 Tetratricopeptide repeat TPR_7 PF13176.6 EFE39687.1 - 2.7e-15 55.2 19.2 0.04 13.9 0.1 9.2 8 1 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFE39687.1 - 3.7e-15 56.0 37.9 0.00019 21.7 0.8 8.5 4 2 4 8 8 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE39687.1 - 4.5e-13 49.2 10.0 7.3e-08 32.5 2.0 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFE39687.1 - 5.4e-10 39.3 30.3 0.00095 19.3 0.3 7.1 3 2 6 9 9 8 6 Tetratricopeptide repeat TPR_15 PF13429.6 EFE39687.1 - 0.00011 21.6 25.7 0.02 14.1 0.3 6.1 2 1 5 7 7 6 3 Tetratricopeptide repeat DUF2225 PF09986.9 EFE39687.1 - 0.0017 18.1 4.6 0.9 9.2 0.0 2.9 2 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) BTAD PF03704.17 EFE39687.1 - 0.045 14.2 0.1 0.045 14.2 0.1 4.8 4 0 0 4 4 3 0 Bacterial transcriptional activator domain ChAPs PF09295.10 EFE39687.1 - 0.33 9.9 2.3 3 6.7 0.4 2.6 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 EFE39687.1 - 0.61 10.0 16.9 20 5.2 0.2 7.1 6 1 1 7 7 7 0 Tetratricopeptide repeat DUF3539 PF12058.8 EFE39688.1 - 0.11 12.6 0.4 0.14 12.3 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3539) BAR PF03114.18 EFE39689.1 - 9.1e-61 205.5 5.9 2.7e-60 204.0 5.9 1.7 1 1 0 1 1 1 1 BAR domain CP12 PF02672.15 EFE39689.1 - 0.014 16.1 0.0 0.081 13.7 0.0 2.3 2 0 0 2 2 2 0 CP12 domain AT_hook PF02178.19 EFE39690.1 - 0.012 15.4 1.5 0.062 13.2 1.5 2.3 1 0 0 1 1 1 0 AT hook motif SSXT PF05030.12 EFE39692.1 - 3.5e-06 26.6 4.9 0.0049 16.5 0.0 2.7 3 0 0 3 3 3 2 SSXT protein (N-terminal region) Pkinase PF00069.25 EFE39694.1 - 1.8e-10 40.6 0.0 2.7e-10 40.1 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39694.1 - 1.3e-07 31.2 0.0 9.9e-07 28.3 0.0 2.2 2 1 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.20 EFE39694.1 - 5.3e-06 26.2 0.2 0.0095 15.5 0.0 2.2 1 1 1 2 2 2 2 Choline/ethanolamine kinase APH PF01636.23 EFE39694.1 - 6.7e-06 26.2 0.3 0.0026 17.7 0.6 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EFE39694.1 - 0.0044 16.4 0.0 0.007 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC_membrane PF00664.23 EFE39695.1 - 6.2e-98 327.8 33.9 7.1e-51 173.5 10.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE39695.1 - 2.3e-71 238.7 0.0 3.3e-35 121.6 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFE39695.1 - 6.3e-16 58.5 6.0 1.1e-06 28.2 1.0 4.4 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFE39695.1 - 3.2e-08 33.9 1.1 0.0049 17.1 0.1 4.0 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFE39695.1 - 5.3e-08 33.4 7.0 0.00065 20.1 0.1 3.6 3 2 1 4 4 2 2 AAA ATPase domain AAA_21 PF13304.6 EFE39695.1 - 3.2e-07 30.5 0.4 0.022 14.6 0.0 4.0 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 EFE39695.1 - 3.3e-07 29.5 0.8 0.026 13.4 0.1 2.9 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 EFE39695.1 - 4e-07 29.7 0.5 0.035 13.8 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EFE39695.1 - 4.6e-07 29.9 0.0 0.0035 17.1 0.0 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA_30 PF13604.6 EFE39695.1 - 2.7e-06 27.2 4.4 0.072 12.8 0.0 4.1 2 2 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EFE39695.1 - 3.4e-06 27.1 0.0 0.021 14.7 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA PF00004.29 EFE39695.1 - 9e-06 26.1 1.1 0.65 10.4 0.1 4.2 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EFE39695.1 - 0.00016 22.3 1.2 0.28 11.7 0.9 2.4 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EFE39695.1 - 0.00038 20.5 0.1 0.57 10.2 0.0 3.5 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EFE39695.1 - 0.00043 19.9 1.2 0.41 10.2 0.0 3.3 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 EFE39695.1 - 0.0005 19.4 0.1 1.3 8.3 0.0 3.2 3 0 0 3 3 3 1 Zeta toxin AAA_7 PF12775.7 EFE39695.1 - 0.00069 19.2 0.1 1.3 8.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region Rad17 PF03215.15 EFE39695.1 - 0.0015 18.5 0.2 0.012 15.5 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 EFE39695.1 - 0.0051 17.4 0.0 0.8 10.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFE39695.1 - 0.0062 16.7 0.1 3.1 7.9 0.0 3.0 2 1 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EFE39695.1 - 0.013 15.7 2.8 3.1 8.1 0.3 3.7 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF87 PF01935.17 EFE39695.1 - 0.023 14.8 0.3 0.51 10.4 0.1 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain PRK PF00485.18 EFE39695.1 - 0.024 14.4 0.1 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family APS_kinase PF01583.20 EFE39695.1 - 0.027 14.4 0.0 4.6 7.1 0.0 2.7 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_24 PF13479.6 EFE39695.1 - 0.04 13.6 0.1 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFE39695.1 - 0.11 12.5 0.6 10 6.2 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EFE39695.1 - 0.12 12.8 0.1 4.4 7.8 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 EFE39695.1 - 0.13 12.3 0.2 27 4.8 0.0 3.9 5 0 0 5 5 5 0 AAA domain MinC_C PF03775.16 EFE39695.1 - 0.14 12.2 0.3 5.2 7.1 0.1 2.9 3 0 0 3 3 2 0 Septum formation inhibitor MinC, C-terminal domain AAA_28 PF13521.6 EFE39695.1 - 0.16 12.2 0.3 1.6 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFE39695.1 - 0.16 11.7 2.2 38 3.9 0.0 3.7 4 0 0 4 4 4 0 IstB-like ATP binding protein p450 PF00067.22 EFE39696.1 - 1.3e-34 119.8 0.0 4e-32 111.6 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 EFE39697.1 - 4.6e-13 48.8 0.7 7.7e-13 48.1 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE39697.1 - 7.5e-06 26.0 10.2 1.7e-05 24.9 10.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_1 PF00515.28 EFE39698.1 - 4.2e-06 26.3 2.5 1.1 9.1 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF3808 PF10300.9 EFE39698.1 - 7.5e-05 21.6 0.4 0.00011 21.1 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EFE39698.1 - 0.015 15.3 4.2 3 8.2 0.0 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE39698.1 - 0.031 14.5 1.4 0.071 13.3 1.4 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Pox_T4_N PF04491.12 EFE39698.1 - 0.19 11.6 0.0 0.49 10.3 0.0 1.7 1 0 0 1 1 1 0 Poxvirus T4 protein, N terminus peroxidase PF00141.23 EFE39699.1 - 4.9e-45 154.0 0.0 8e-45 153.3 0.0 1.4 1 0 0 1 1 1 1 Peroxidase Pkinase PF00069.25 EFE39701.1 - 2.6e-12 46.7 0.0 3e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39701.1 - 6.7e-08 32.1 0.0 8.5e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase COesterase PF00135.28 EFE39702.1 - 9.4e-50 169.9 0.0 1.2e-49 169.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE39702.1 - 0.00033 20.6 0.0 0.0018 18.1 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Zn_clus PF00172.18 EFE39703.1 - 9.1e-09 35.3 6.3 1.8e-08 34.4 6.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Crp PF00325.20 EFE39703.1 - 0.016 14.9 0.1 0.59 9.8 0.1 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family Pyridoxal_deC PF00282.19 EFE39704.1 - 6.2e-76 255.5 0.0 8e-76 255.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EFE39704.1 - 3.6e-05 22.9 0.0 5.3e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 EFE39704.1 - 0.0061 15.3 0.1 0.032 13.0 0.0 2.0 2 0 0 2 2 2 1 Orn/Lys/Arg decarboxylase, major domain DegT_DnrJ_EryC1 PF01041.17 EFE39704.1 - 0.073 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Peptidase_S8 PF00082.22 EFE39705.1 - 5.8e-17 61.9 1.1 6.2e-17 61.8 1.1 1.0 1 0 0 1 1 1 1 Subtilase family DUF5556 PF17711.1 EFE39705.1 - 0.068 13.1 0.0 0.097 12.6 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5556) eIF-5_eIF-2B PF01873.17 EFE39706.1 - 7.9e-35 119.3 0.0 1.4e-34 118.4 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EFE39706.1 - 1.5e-21 76.3 0.4 1.5e-21 76.3 0.4 2.2 2 1 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon PcfK PF14058.6 EFE39706.1 - 0.31 11.3 0.1 0.31 11.3 0.1 3.1 3 0 0 3 3 3 0 PcfK-like protein HEAT_2 PF13646.6 EFE39707.1 - 0.0026 18.1 1.7 1.5 9.2 0.0 3.9 4 0 0 4 4 4 2 HEAT repeats TTRAP PF14203.6 EFE39707.1 - 0.0052 16.7 0.8 0.095 12.7 0.1 3.3 3 0 0 3 3 3 1 Putative tranposon-transfer assisting protein DUF824 PF05688.11 EFE39707.1 - 0.075 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) GMC_oxred_N PF00732.19 EFE39708.1 - 4.7e-46 157.5 0.0 6e-46 157.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFE39708.1 - 3.5e-33 115.1 0.0 5.6e-33 114.5 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_3 PF13738.6 EFE39708.1 - 0.034 13.4 0.1 4.3 6.5 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFE39708.1 - 0.04 13.0 0.9 0.059 12.4 0.2 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EFE39708.1 - 0.052 12.6 1.2 0.19 10.8 0.9 1.8 2 0 0 2 2 2 0 FAD binding domain NAD_binding_8 PF13450.6 EFE39708.1 - 0.13 12.5 0.0 0.35 11.1 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFE39708.1 - 0.13 10.9 0.3 0.19 10.4 0.3 1.1 1 0 0 1 1 1 0 HI0933-like protein Catalase PF00199.19 EFE39709.1 - 1.7e-101 340.1 0.5 2.2e-101 339.8 0.5 1.1 1 0 0 1 1 1 1 Catalase Spot_14 PF07084.12 EFE39710.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 Myb_DNA-bind_6 PF13921.6 EFE39711.1 - 1.8e-15 57.0 0.0 2.6e-07 30.8 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFE39711.1 - 1.4e-12 47.6 0.1 2.5e-06 27.5 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EFE39711.1 - 0.0053 16.8 0.0 3.9 7.5 0.0 2.5 2 0 0 2 2 2 2 SLIDE Nop16 PF09420.10 EFE39711.1 - 0.022 14.8 0.8 0.16 12.0 0.0 2.3 2 0 0 2 2 2 0 Ribosome biogenesis protein Nop16 PX PF00787.24 EFE39712.1 - 2.5e-26 91.9 0.2 2.5e-26 91.9 0.2 1.5 2 0 0 2 2 2 1 PX domain Peptidase_A2E PF12382.8 EFE39712.1 - 0.067 13.2 0.1 0.48 10.4 0.0 2.0 2 0 0 2 2 2 0 Retrotransposon peptidase WD40 PF00400.32 EFE39713.1 - 3.9e-16 59.1 16.1 0.004 17.9 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EFE39713.1 - 4.4e-06 25.5 0.8 0.025 13.1 0.1 3.9 4 0 0 4 4 4 2 Cytochrome D1 heme domain ANAPC4_WD40 PF12894.7 EFE39713.1 - 2.8e-05 24.3 0.1 0.34 11.2 0.0 4.2 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EFE39713.1 - 0.0025 18.3 4.1 0.19 12.2 0.1 4.2 4 0 0 4 4 4 1 PQQ-like domain PD40 PF07676.12 EFE39713.1 - 0.023 14.6 2.7 0.072 13.1 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Nop14 PF04147.12 EFE39713.1 - 4 5.5 9.4 5.3 5.1 9.4 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EFE39713.1 - 9.2 4.2 18.2 13 3.8 18.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_ner PF04546.13 EFE39713.1 - 9.7 6.0 7.1 15 5.4 7.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region RRM_1 PF00076.22 EFE39714.1 - 2e-06 27.5 0.0 3.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Menin PF05053.13 EFE39714.1 - 0.15 10.4 2.2 0.22 9.8 2.2 1.2 1 0 0 1 1 1 0 Menin SecE PF00584.20 EFE39715.1 - 1e-10 41.4 0.0 2e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Mito_carr PF00153.27 EFE39717.1 - 4.7e-71 234.8 2.1 1e-24 86.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 EFE39717.1 - 0.17 12.1 0.0 7.5 6.9 0.0 3.0 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase FAM176 PF14851.6 EFE39718.1 - 0.016 14.9 4.8 0.02 14.6 4.8 1.1 1 0 0 1 1 1 0 FAM176 family MAP17 PF15807.5 EFE39718.1 - 0.023 14.9 3.9 0.031 14.5 3.9 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 G0-G1_switch_2 PF15103.6 EFE39718.1 - 0.25 11.8 3.4 0.31 11.5 3.4 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 Phage_Gp23 PF10669.9 EFE39718.1 - 0.28 11.5 8.3 0.38 11.1 8.3 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Connexin PF00029.19 EFE39718.1 - 0.34 10.6 2.2 0.4 10.4 2.2 1.0 1 0 0 1 1 1 0 Connexin CDC45 PF02724.14 EFE39718.1 - 0.51 8.6 6.1 0.5 8.6 6.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EFE39718.1 - 0.94 8.2 2.2 0.85 8.3 2.2 1.0 1 0 0 1 1 1 0 Presenilin DUF1682 PF07946.14 EFE39718.1 - 1 8.5 8.8 1.2 8.3 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) TRAP_alpha PF03896.16 EFE39718.1 - 1.2 8.2 4.1 1.3 8.1 4.1 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Kinesin PF00225.23 EFE39719.1 - 1.7e-89 300.0 1.5 1.2e-88 297.3 0.0 3.0 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFE39719.1 - 2.3e-17 63.3 0.0 9.3e-14 51.6 0.0 3.6 3 0 0 3 3 3 2 Microtubule binding SHE3 PF17078.5 EFE39719.1 - 0.0024 17.7 19.2 0.0024 17.7 19.2 8.5 4 2 3 8 8 8 1 SWI5-dependent HO expression protein 3 Glycos_transf_1 PF00534.20 EFE39720.1 - 2.4e-31 108.6 0.0 1.6e-29 102.7 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFE39720.1 - 1.5e-19 70.6 0.4 2.5e-19 69.9 0.4 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EFE39720.1 - 3.6e-14 53.4 0.0 2.2e-13 50.8 0.0 2.3 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFE39720.1 - 6.6e-09 36.4 0.6 1.1e-08 35.7 0.6 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EFE39720.1 - 3e-05 24.3 0.0 6.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 ALG11_N PF15924.5 EFE39720.1 - 0.019 15.1 0.0 4.5 7.3 0.0 2.4 2 0 0 2 2 2 0 ALG11 mannosyltransferase N-terminus Peptidase_M19 PF01244.21 EFE39721.1 - 4.3e-109 364.5 0.0 5.1e-109 364.3 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) ERCC4 PF02732.15 EFE39722.1 - 1.7e-25 90.0 0.0 8.7e-25 87.7 0.0 2.2 2 0 0 2 2 2 1 ERCC4 domain RCDG1 PF15725.5 EFE39722.1 - 1.1 9.8 7.0 0.28 11.6 1.6 2.7 3 0 0 3 3 3 0 Renal cancer differentiation gene 1 protein MFS_1 PF07690.16 EFE39723.1 - 1.4e-15 57.1 27.2 1.4e-15 57.1 27.2 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Nodulin-like PF06813.13 EFE39723.1 - 0.0031 17.1 15.6 0.007 15.9 0.9 3.8 3 1 1 4 4 4 2 Nodulin-like DNA_pol_phi PF04931.13 EFE39724.1 - 0.91 7.5 12.5 0.89 7.6 12.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF2956 PF11169.8 EFE39724.1 - 1.2 9.4 5.4 0.12 12.5 1.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Nop14 PF04147.12 EFE39724.1 - 1.7 6.7 11.2 1.9 6.6 11.2 1.1 1 0 0 1 1 1 0 Nop14-like family PI3K_1B_p101 PF10486.9 EFE39724.1 - 3 5.5 4.3 2.8 5.6 4.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CENP-B_dimeris PF09026.10 EFE39724.1 - 4.8 7.6 14.9 3.1 8.3 12.7 1.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CDC27 PF09507.10 EFE39724.1 - 5 6.4 11.9 5.8 6.2 11.9 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RXT2_N PF08595.11 EFE39724.1 - 8.2 6.4 11.5 2.4 8.2 9.0 1.4 1 1 1 2 2 2 0 RXT2-like, N-terminal DUF1676 PF07898.13 EFE39725.1 - 9.4 6.2 12.2 15 5.5 12.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) IPK PF03770.16 EFE39726.1 - 9.1e-56 188.8 0.0 9.1e-56 188.8 0.0 1.7 2 0 0 2 2 2 1 Inositol polyphosphate kinase Pam17 PF08566.10 EFE39726.1 - 0.054 13.4 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 LRR_4 PF12799.7 EFE39727.1 - 1.2e-23 82.8 41.3 3.5e-05 24.1 1.5 9.0 8 1 0 9 9 9 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFE39727.1 - 9.5e-19 66.9 43.6 6.3e-07 29.1 3.2 7.5 4 1 5 10 10 10 8 Leucine rich repeat LRR_9 PF14580.6 EFE39727.1 - 3.1e-11 43.1 11.1 8.9e-06 25.3 0.8 4.3 2 1 2 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 EFE39727.1 - 1.2 9.4 30.4 1.8 8.8 1.3 9.3 10 1 0 11 11 11 0 Leucine Rich repeat Adaptin_binding PF10199.9 EFE39729.1 - 9.6e-18 64.9 5.7 9.6e-18 64.9 5.7 1.9 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 PGP_phosphatase PF09419.10 EFE39730.1 - 2.4e-52 176.9 0.0 5.3e-52 175.8 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EFE39730.1 - 2.9e-06 27.2 0.1 5.5e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EFE39730.1 - 0.00022 21.6 0.1 0.31 11.3 0.1 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase TPP_enzyme_M PF00205.22 EFE39730.1 - 0.061 13.1 0.0 0.14 11.9 0.0 1.6 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Homeodomain PF00046.29 EFE39731.1 - 3.6e-20 71.6 2.5 8.2e-20 70.4 2.5 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EFE39731.1 - 0.0016 18.3 0.4 0.004 17.0 0.4 1.7 1 0 0 1 1 1 1 Homeobox KN domain FAM199X PF15814.5 EFE39731.1 - 1.1 8.3 9.4 2.2 7.3 9.4 1.5 1 0 0 1 1 1 0 Protein family FAM199X HNF-1_N PF04814.13 EFE39731.1 - 2.2 8.9 10.2 0.34 11.5 5.1 2.1 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Aldedh PF00171.22 EFE39734.1 - 3.6e-104 348.8 0.0 4.7e-104 348.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Tubulin PF00091.25 EFE39735.1 - 3.1e-54 184.2 0.0 7e-54 183.0 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFE39735.1 - 1e-43 148.5 0.1 1.7e-43 147.8 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 EFE39735.1 - 0.00061 19.1 0.0 0.028 13.6 0.0 2.1 2 0 0 2 2 2 2 Tubulin like Tubulin_3 PF14881.6 EFE39735.1 - 0.0035 17.1 0.0 0.0075 16.0 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain RRM_1 PF00076.22 EFE39736.1 - 6.6e-12 45.1 0.3 0.00037 20.2 0.0 3.9 4 1 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFE39736.1 - 0.04 13.9 7.7 0.31 11.1 0.0 3.4 3 0 0 3 3 3 0 RNA binding motif Porph_ging PF09697.10 EFE39736.1 - 0.38 11.3 4.2 0.78 10.3 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) Peptidase_S49_N PF08496.10 EFE39736.1 - 0.43 10.6 3.0 0.28 11.3 0.4 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Pkinase PF00069.25 EFE39737.1 - 5.2e-66 222.7 0.0 8.3e-66 222.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39737.1 - 1.8e-34 119.2 0.0 1.4e-33 116.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE39737.1 - 2.8e-06 26.4 0.1 5.2e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFE39737.1 - 4e-06 26.4 0.1 2.4e-05 23.8 0.1 2.1 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EFE39737.1 - 2e-05 24.6 0.0 0.005 16.8 0.1 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFE39737.1 - 0.0098 15.0 0.1 0.018 14.1 0.1 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 EFE39737.1 - 0.075 12.4 0.8 0.58 9.5 0.1 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_pack_N PF02500.15 EFE39737.1 - 0.089 12.6 0.2 0.18 11.6 0.2 1.4 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus Goodbye PF17109.5 EFE39738.1 - 8.8e-31 106.9 0.4 5.8e-30 104.2 0.4 2.6 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain TPR_6 PF13174.6 EFE39738.1 - 0.064 13.9 1.7 33 5.4 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5343 PF17278.2 EFE39738.1 - 0.23 11.5 1.8 0.49 10.5 0.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5343) TPR_19 PF14559.6 EFE39738.1 - 0.67 10.5 3.4 5.3 7.6 0.1 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat LANC_like PF05147.13 EFE39739.1 - 6.3e-16 57.9 0.0 3.6e-13 48.8 0.0 2.8 2 1 0 2 2 2 2 Lanthionine synthetase C-like protein CBF PF03914.17 EFE39740.1 - 5.3e-54 182.8 0.1 5.3e-54 182.8 0.1 3.1 4 0 0 4 4 4 1 CBF/Mak21 family Prok-E2_C PF14459.6 EFE39740.1 - 0.086 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family C Cnd1 PF12717.7 EFE39740.1 - 0.1 12.6 0.3 1.5 8.9 0.0 2.4 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 tRNA-synt_2b PF00587.25 EFE39741.1 - 1.5e-29 103.3 0.0 5.7e-29 101.3 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFE39741.1 - 2.1e-09 37.4 0.0 5.2e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain zf-ribbon_3 PF13248.6 EFE39741.1 - 0.061 12.8 2.9 0.064 12.7 0.4 2.1 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 EFE39741.1 - 0.24 10.9 2.9 2.4 7.7 0.3 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding Prefoldin PF02996.17 EFE39742.1 - 2.1e-15 56.7 0.0 2.7e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit KH_1 PF00013.29 EFE39743.1 - 0.0035 17.1 0.0 0.58 10.0 0.0 2.7 2 0 0 2 2 2 2 KH domain CAP PF00188.26 EFE39744.1 - 3.9e-14 53.6 7.1 5.7e-14 53.0 7.1 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PPTA PF01239.22 EFE39744.1 - 0.33 10.8 1.4 0.7 9.7 1.4 1.5 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat Abhydrolase_6 PF12697.7 EFE39745.1 - 8.7e-16 59.2 0.2 3.1e-14 54.1 0.2 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFE39745.1 - 3.1e-12 46.7 0.0 2.3e-11 43.8 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold EHN PF06441.12 EFE39745.1 - 0.016 15.6 0.2 0.034 14.5 0.2 1.5 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Hydrolase_4 PF12146.8 EFE39745.1 - 0.018 14.3 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Med10 PF09748.9 EFE39745.1 - 0.096 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex Glyco_transf_8 PF01501.20 EFE39746.1 - 5.3e-21 75.3 0.2 1.1e-20 74.3 0.2 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 HEAT PF02985.22 EFE39747.1 - 1.3e-42 140.2 11.9 0.015 15.5 0.1 12.9 13 0 0 13 13 13 11 HEAT repeat HEAT_2 PF13646.6 EFE39747.1 - 5.3e-37 126.1 4.8 9.6e-10 38.7 0.0 8.2 4 2 3 8 8 8 8 HEAT repeats HEAT_EZ PF13513.6 EFE39747.1 - 2.7e-15 56.5 5.9 5e-05 23.7 0.0 8.7 9 1 1 10 10 10 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EFE39747.1 - 6.8e-12 45.8 3.0 0.00062 20.3 0.2 7.3 6 2 3 9 9 9 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EFE39747.1 - 2.1e-10 40.9 10.5 0.0085 16.1 0.4 6.0 6 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EFE39747.1 - 8.3e-08 31.2 5.4 1.5e-06 27.1 1.0 3.6 2 1 1 4 4 4 1 Adaptin N terminal region RTP1_C1 PF10363.9 EFE39747.1 - 4.9e-05 23.5 4.6 2.8 8.1 0.1 4.5 3 1 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EFE39747.1 - 0.0098 15.5 2.8 2 8.0 0.2 4.3 4 2 1 5 5 5 1 CLASP N terminal Proteasom_PSMB PF10508.9 EFE39747.1 - 0.061 11.8 5.2 2.8 6.3 1.9 2.4 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit TetR_C_16 PF17920.1 EFE39747.1 - 0.11 12.8 0.4 18 5.6 0.0 3.4 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain IFRD PF05004.13 EFE39747.1 - 0.26 10.4 1.2 1.5 7.8 0.0 2.9 3 1 1 4 4 4 0 Interferon-related developmental regulator (IFRD) Arm PF00514.23 EFE39747.1 - 0.38 10.8 7.2 2 8.6 0.0 4.9 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat Xpo1 PF08389.12 EFE39747.1 - 1.3 9.1 4.3 1.8 8.6 0.6 3.0 2 1 0 3 3 3 0 Exportin 1-like protein API5 PF05918.11 EFE39747.1 - 2.8 6.7 7.1 1.1 8.0 2.3 2.7 3 1 0 3 3 3 0 Apoptosis inhibitory protein 5 (API5) tRNA_synthFbeta PF17759.1 EFE39748.1 - 5.4e-50 169.8 0.0 7.7e-50 169.3 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 EFE39748.1 - 8.3e-25 87.5 0.1 1.6e-24 86.5 0.1 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EFE39748.1 - 1.8e-15 57.0 0.0 3.4e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase B5 domain DUF2740 PF10872.8 EFE39748.1 - 0.056 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) Ribosomal_S3_C PF00189.20 EFE39749.1 - 3.7e-25 88.2 0.1 2e-24 85.9 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EFE39749.1 - 6.5e-12 45.1 0.1 1.2e-11 44.3 0.1 1.4 1 0 0 1 1 1 1 KH domain Coilin_N PF15862.5 EFE39749.1 - 0.05 13.4 0.1 0.34 10.7 0.0 2.0 2 0 0 2 2 2 0 Coilin N-terminus UN_NPL4 PF11543.8 EFE39749.1 - 0.1 13.1 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Myotub-related PF06602.14 EFE39750.1 - 6.6e-147 489.0 0.0 8e-147 488.8 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 EFE39750.1 - 0.0011 19.0 0.2 0.0039 17.2 0.0 1.8 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFE39750.1 - 0.071 12.7 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase SLS PF14611.6 EFE39751.1 - 8e-36 123.9 0.2 1.3e-35 123.3 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator EcoEI_R_C PF08463.10 EFE39751.1 - 0.01 16.0 0.4 0.02 15.0 0.4 1.4 1 0 0 1 1 1 0 EcoEI R protein C-terminal NT-C2 PF10358.9 EFE39752.1 - 5.9e-28 97.4 0.0 7.9e-28 97.0 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins p450 PF00067.22 EFE39753.1 - 1.5e-20 73.4 0.0 4.2e-13 48.8 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 p450 PF00067.22 EFE39754.1 - 6.9e-55 186.6 0.0 9.3e-55 186.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Mgr1 PF08602.10 EFE39755.1 - 0.061 12.1 2.4 0.077 11.8 2.4 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Seryl_tRNA_N PF02403.22 EFE39755.1 - 0.43 10.8 12.8 0.3 11.3 11.4 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HAUS6_N PF14661.6 EFE39755.1 - 2 8.0 11.3 2.6 7.5 11.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Coiled-coil_56 PF09813.9 EFE39755.1 - 6.7 6.8 11.1 3.7 7.7 9.0 1.6 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 56 Atg14 PF10186.9 EFE39755.1 - 8.8 5.3 11.4 12 4.9 11.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1682 PF07946.14 EFE39755.1 - 9.3 5.4 17.7 14 4.8 17.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Pkinase_fungal PF17667.1 EFE39756.1 - 1.3e-138 462.2 0.2 1.6e-138 461.9 0.2 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EFE39756.1 - 7.5e-08 32.1 0.0 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39756.1 - 0.006 15.9 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE39756.1 - 0.045 13.7 0.0 0.32 10.9 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 EFE39756.1 - 0.056 13.0 0.0 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 RIO1 family HMMR_N PF15905.5 EFE39756.1 - 6.4 6.1 8.0 3.4 7.1 5.0 1.8 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Hce2 PF14856.6 EFE39759.1 - 1e-05 25.8 0.1 1.8e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor MARVEL PF01284.23 EFE39760.1 - 1.4e-22 80.3 9.5 1.7e-22 80.0 9.5 1.0 1 0 0 1 1 1 1 Membrane-associating domain Pkinase PF00069.25 EFE39761.1 - 8.7e-73 244.9 0.0 1.2e-72 244.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39761.1 - 1.1e-36 126.5 0.0 1.5e-36 126.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 EFE39761.1 - 1.7e-18 67.2 0.2 5.2e-11 43.0 0.1 2.7 2 1 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 EFE39761.1 - 2.5e-16 59.5 0.0 5.9e-16 58.3 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EFE39761.1 - 4.1e-06 26.3 0.0 8.6e-06 25.3 0.0 1.6 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EFE39761.1 - 0.00015 21.4 0.2 0.00035 20.2 0.2 1.5 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 EFE39761.1 - 0.00092 18.3 0.3 0.0022 17.0 0.3 1.6 1 1 0 1 1 1 1 Haspin like kinase domain YukC PF10140.9 EFE39761.1 - 0.0076 15.1 0.2 0.012 14.5 0.2 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC APH PF01636.23 EFE39761.1 - 0.016 15.2 0.2 0.062 13.2 0.1 1.9 1 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EFE39761.1 - 0.13 11.5 0.1 0.24 10.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EFE39761.1 - 0.17 10.9 0.5 0.27 10.3 0.5 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 His_Phos_1 PF00300.22 EFE39762.1 - 3.2e-25 89.0 0.0 4.3e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PRELI PF04707.14 EFE39763.1 - 1.9e-23 83.1 0.0 1.7e-20 73.4 0.0 2.1 2 0 0 2 2 2 2 PRELI-like family UPRTase PF14681.6 EFE39764.1 - 3.7e-40 137.6 0.7 5.6e-40 137.0 0.7 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_17 PF13207.6 EFE39764.1 - 2e-19 70.3 0.0 7.5e-19 68.5 0.0 2.0 2 0 0 2 2 1 1 AAA domain HAD PF12710.7 EFE39764.1 - 2.4e-15 57.4 0.0 4.5e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase KAP_NTPase PF07693.14 EFE39764.1 - 8.4e-08 31.8 0.0 2.5e-07 30.3 0.0 1.7 2 0 0 2 2 2 1 KAP family P-loop domain AAA_18 PF13238.6 EFE39764.1 - 4.2e-07 30.6 0.0 9.8e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFE39764.1 - 1.5e-05 25.4 0.0 3.2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EFE39764.1 - 0.0038 16.5 0.1 0.014 14.6 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 EFE39764.1 - 0.0041 16.9 0.0 0.0076 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFE39764.1 - 0.0055 16.9 0.1 0.024 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EFE39764.1 - 0.0062 15.7 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 G-protein alpha subunit AAA_22 PF13401.6 EFE39764.1 - 0.0064 16.8 0.0 0.031 14.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain Hydrolase_3 PF08282.12 EFE39764.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase ABC_tran PF00005.27 EFE39764.1 - 0.016 15.7 0.0 0.042 14.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter PRTase_2 PF15609.6 EFE39764.1 - 0.022 14.3 0.0 0.043 13.3 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosyl transferase Pribosyltran PF00156.27 EFE39764.1 - 0.023 14.2 0.5 0.12 11.9 0.5 2.1 1 1 0 1 1 1 0 Phosphoribosyl transferase domain NB-ARC PF00931.22 EFE39764.1 - 0.024 13.8 0.0 0.057 12.6 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA PF00004.29 EFE39764.1 - 0.024 15.1 0.0 0.064 13.7 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EFE39764.1 - 0.025 14.5 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea SRP54 PF00448.22 EFE39764.1 - 0.028 14.0 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain MobB PF03205.14 EFE39764.1 - 0.035 14.0 0.0 0.084 12.8 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.12 EFE39764.1 - 0.043 13.7 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain PduV-EutP PF10662.9 EFE39764.1 - 0.057 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EFE39764.1 - 0.059 13.0 0.6 0.16 11.5 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Peptidase_U4 PF03419.13 EFE39764.1 - 0.067 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Sporulation factor SpoIIGA RsgA_GTPase PF03193.16 EFE39764.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase SRPRB PF09439.10 EFE39764.1 - 0.086 12.3 0.1 2.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_30 PF13604.6 EFE39764.1 - 0.096 12.4 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EFE39764.1 - 0.096 12.4 0.0 0.3 10.8 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Pox_A32 PF04665.12 EFE39764.1 - 0.1 12.0 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_28 PF13521.6 EFE39764.1 - 0.13 12.5 0.0 0.57 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 EFE39764.1 - 0.13 12.3 0.0 0.74 9.9 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase APS_kinase PF01583.20 EFE39764.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Methyltransf_23 PF13489.6 EFE39765.1 - 0.0084 16.0 0.0 2 8.2 0.0 2.3 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_2 PF00891.18 EFE39766.1 - 2.2e-34 118.6 0.0 3.3e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 EFE39766.1 - 0.00025 21.8 0.0 0.00043 21.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE39766.1 - 0.00056 20.6 0.0 0.0013 19.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NAD_binding_4 PF07993.12 EFE39767.1 - 1.4e-56 191.5 0.0 2.1e-56 191.0 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EFE39767.1 - 2e-29 102.4 0.1 2.8e-29 102.0 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EFE39767.1 - 9.8e-12 45.1 0.2 2.1e-11 44.0 0.2 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EFE39767.1 - 4.9e-08 32.7 0.0 1.5e-07 31.2 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFE39767.1 - 6.8e-06 25.3 0.0 1.5e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFE39767.1 - 0.056 12.8 0.0 0.18 11.1 0.0 1.7 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase AMP-binding PF00501.28 EFE39768.1 - 2.7e-33 115.2 0.3 5e-33 114.3 0.3 1.4 1 1 0 1 1 1 1 AMP-binding enzyme NmrA PF05368.13 EFE39769.1 - 1.9e-39 135.6 0.0 2.7e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFE39769.1 - 7.9e-17 61.7 0.0 1.1e-16 61.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFE39769.1 - 0.00081 18.9 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EFE39769.1 - 0.0033 17.9 0.1 0.0065 16.9 0.1 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EFE39769.1 - 0.0063 17.1 0.2 0.024 15.2 0.2 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 EFE39769.1 - 0.14 12.3 0.1 0.29 11.2 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus p450 PF00067.22 EFE39770.1 - 1.2e-39 136.4 0.0 1.6e-39 135.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF4296 PF14129.6 EFE39770.1 - 0.16 12.6 0.0 0.34 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) AMP-binding PF00501.28 EFE39771.1 - 1.6e-32 112.7 0.1 2.8e-32 111.9 0.1 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EFE39771.1 - 4.2e-22 78.5 0.0 6.3e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EFE39771.1 - 7.4e-08 32.6 0.9 1.8e-07 31.4 0.2 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site PetN PF03742.14 EFE39772.1 - 0.034 14.0 2.4 0.056 13.3 2.4 1.3 1 0 0 1 1 1 0 PetN adh_short PF00106.25 EFE39773.1 - 2.7e-18 66.1 0.3 3.3e-15 56.1 0.1 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFE39773.1 - 8.5e-10 38.6 0.1 5.5e-09 35.9 0.2 2.0 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE39773.1 - 4.1e-06 26.8 0.0 5.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFE39773.1 - 0.00072 18.8 0.0 0.001 18.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Methyltransf_25 PF13649.6 EFE39774.1 - 1.2e-10 42.0 0.0 3.1e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE39774.1 - 3.6e-08 33.3 0.0 6.5e-08 32.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE39774.1 - 3.1e-07 31.1 0.0 7.6e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE39774.1 - 5.1e-06 27.1 0.0 1.9e-05 25.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Peptidase_M20 PF01546.28 EFE39775.1 - 2.6e-32 112.2 0.0 3.3e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFE39775.1 - 5.6e-11 42.3 0.0 8.4e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFE39775.1 - 0.021 14.5 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M28 CobS_N PF12556.8 EFE39775.1 - 0.063 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Cobaltochelatase CobS subunit N terminal Pkinase PF00069.25 EFE39776.1 - 3.1e-05 23.5 0.0 5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFE39776.1 - 0.00031 20.8 0.1 0.00031 20.8 0.1 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family HSDR_N_2 PF13588.6 EFE39776.1 - 0.0015 18.5 0.0 0.54 10.3 0.0 2.6 1 1 0 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) Kdo PF06293.14 EFE39776.1 - 0.012 15.0 0.1 0.022 14.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFE39776.1 - 0.02 14.5 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase MRP-L20 PF12824.7 EFE39777.1 - 1.5e-57 194.4 2.5 1.7e-57 194.2 2.5 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 EFE39777.1 - 0.014 15.5 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 Neugrin Tir_receptor_C PF07489.11 EFE39778.1 - 0.12 12.3 5.0 0.3 11.0 5.0 1.6 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Dicty_REP PF05086.12 EFE39778.1 - 0.74 7.7 3.0 1 7.3 3.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 EFE39778.1 - 1.9 8.5 15.4 0.23 11.4 9.7 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein Cys_Met_Meta_PP PF01053.20 EFE39779.1 - 1.5e-24 86.3 0.0 3.2e-24 85.2 0.0 1.5 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Mt_ATP_synt PF15704.5 EFE39779.1 - 0.15 12.0 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ATP synthase subunit Nrap_D2 PF17403.2 EFE39780.1 - 2.9e-51 173.2 0.0 5.8e-49 165.8 0.0 2.5 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain Nrap_D5 PF17406.2 EFE39780.1 - 6.7e-51 172.3 1.5 1.1e-50 171.6 0.2 2.1 3 0 0 3 3 3 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 EFE39780.1 - 1.7e-41 141.8 0.2 3.1e-41 141.0 0.2 1.5 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D4 PF17405.2 EFE39780.1 - 2.4e-41 141.4 0.2 4.9e-41 140.4 0.2 1.5 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D3 PF17404.2 EFE39780.1 - 2.8e-39 134.8 0.0 6.2e-39 133.6 0.0 1.6 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 EFE39780.1 - 3.6e-28 98.4 0.0 8.8e-28 97.2 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 Fibroin_P25 PF07294.11 EFE39780.1 - 0.087 12.9 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Fibroin P25 Spc7 PF08317.11 EFE39780.1 - 0.11 11.4 0.1 0.2 10.5 0.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein I-set PF07679.16 EFE39781.1 - 0.0099 15.9 0.1 0.37 10.9 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin I-set domain DUF1918 PF08940.11 EFE39781.1 - 0.011 15.4 0.0 11 5.8 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF1918) Peptidase_C12 PF01088.21 EFE39782.1 - 2.8e-63 213.5 0.2 4.9e-63 212.7 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 SPX PF03105.19 EFE39783.1 - 6.8e-47 161.2 0.0 1.3e-46 160.3 0.0 1.5 1 0 0 1 1 1 1 SPX domain zf-C3HC4_3 PF13920.6 EFE39783.1 - 7.8e-07 28.9 9.7 1.4e-06 28.0 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFE39783.1 - 1e-05 25.6 10.8 1e-05 25.6 10.8 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EFE39783.1 - 1.6e-05 24.7 11.5 4e-05 23.4 11.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE39783.1 - 2.7e-05 24.0 10.9 6.9e-05 22.7 10.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFE39783.1 - 0.00014 22.2 12.7 0.00032 21.0 12.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFE39783.1 - 0.00021 21.1 12.1 0.00049 19.9 12.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE39783.1 - 0.00024 21.0 9.7 0.0006 19.8 9.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EFE39783.1 - 0.0099 15.9 3.5 0.022 14.8 3.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EFE39783.1 - 0.01 15.7 10.4 0.037 13.9 10.6 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EFE39783.1 - 0.012 15.4 3.6 0.012 15.4 3.6 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain TerY_C PF15616.6 EFE39783.1 - 0.045 13.9 1.0 0.088 12.9 1.0 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain zf-rbx1 PF12678.7 EFE39783.1 - 0.26 11.6 10.2 0.87 9.9 10.2 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-P11 PF03854.14 EFE39783.1 - 0.81 9.4 9.0 21 4.9 9.3 2.3 1 1 1 2 2 2 0 P-11 zinc finger YccV-like PF08755.11 EFE39784.1 - 5.8e-30 103.7 0.3 2.6e-29 101.6 0.1 2.1 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like Transglut_core2 PF13369.6 EFE39784.1 - 2.2e-15 56.5 0.0 3.8e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box-like PF12937.7 EFE39784.1 - 7.7e-06 25.7 0.0 1.8e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE39784.1 - 0.0014 18.4 0.0 0.0029 17.4 0.0 1.6 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 EFE39784.1 - 0.0023 18.4 0.1 0.0048 17.4 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A 23S_rRNA_IVP PF05635.11 EFE39784.1 - 0.048 14.0 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 23S rRNA-intervening sequence protein Adeno_E4 PF05385.11 EFE39785.1 - 0.25 11.4 0.8 1 9.5 0.0 2.1 2 0 0 2 2 2 0 Mastadenovirus early E4 13 kDa protein DnaJ PF00226.31 EFE39786.1 - 3.1e-25 88.1 0.3 9.8e-25 86.5 0.3 1.9 1 0 0 1 1 1 1 DnaJ domain zf-met PF12874.7 EFE39786.1 - 2.6e-12 46.7 7.5 9.1e-09 35.4 2.7 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFE39786.1 - 1.4e-11 44.4 9.7 9.2e-10 38.6 6.5 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EFE39786.1 - 6.7e-10 39.2 6.6 0.00023 21.5 1.9 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EFE39786.1 - 5.7e-07 29.6 6.1 0.012 16.0 0.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE39786.1 - 1.3e-06 28.8 4.5 0.016 16.0 0.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger Actin_micro PF17003.5 EFE39786.1 - 0.00088 18.5 1.4 0.22 10.7 0.2 2.1 2 0 0 2 2 2 2 Putative actin-like family zf-C2H2_3rep PF18868.1 EFE39786.1 - 0.0033 18.1 1.9 1.9 9.2 0.1 2.8 2 0 0 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 EFE39786.1 - 0.0086 16.1 9.4 0.72 9.9 0.5 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger LIM PF00412.22 EFE39786.1 - 0.011 16.0 2.0 1.8 8.9 0.6 2.4 2 0 0 2 2 2 0 LIM domain DUF3449 PF11931.8 EFE39786.1 - 0.046 13.5 0.1 0.046 13.5 0.1 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF3449) zf-BED PF02892.15 EFE39786.1 - 0.13 12.3 0.4 24 5.0 0.2 2.4 2 0 0 2 2 2 0 BED zinc finger zf-MYST PF17772.1 EFE39786.1 - 0.13 11.9 0.2 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 MYST family zinc finger domain DUF2256 PF10013.9 EFE39786.1 - 0.19 11.9 1.1 21 5.3 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-H2C2_2 PF13465.6 EFE39786.1 - 0.37 11.3 1.6 5.5 7.6 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger double domain MRNIP PF15749.5 EFE39786.1 - 6.6 7.5 15.8 0.058 14.1 3.1 3.2 2 1 0 2 2 2 0 MRN-interacting protein R3H PF01424.22 EFE39787.1 - 1.8e-11 43.8 0.0 4.7e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 EFE39787.1 - 6e-09 35.7 0.4 1.5e-08 34.4 0.4 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFE39787.1 - 0.0034 17.4 0.2 0.0034 17.4 0.2 3.4 4 0 0 4 4 4 1 G-patch domain Peptidase_S49_N PF08496.10 EFE39787.1 - 0.017 15.2 6.1 0.017 15.2 6.1 3.1 3 0 0 3 3 3 0 Peptidase family S49 N-terminal Peptidase_C54 PF03416.19 EFE39788.1 - 6.8e-65 219.2 0.0 1.4e-64 218.2 0.0 1.5 2 0 0 2 2 2 1 Peptidase family C54 Dicty_REP PF05086.12 EFE39788.1 - 1.7 6.6 8.0 2.2 6.2 8.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Histone PF00125.24 EFE39790.1 - 3.5e-18 66.2 0.4 5.3e-18 65.6 0.4 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFE39790.1 - 5.9e-05 23.3 0.1 0.00012 22.3 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EFE39790.1 - 0.003 18.0 0.0 0.005 17.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.13 EFE39790.1 - 0.048 13.3 0.2 0.088 12.5 0.2 1.4 1 1 0 1 1 1 0 Replication protein C N-terminal domain DUF3915 PF13054.6 EFE39790.1 - 0.072 13.1 0.0 0.089 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) CNDH2_C PF16858.5 EFE39790.1 - 0.079 12.8 1.3 0.083 12.8 1.3 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Histone_H2A_C PF16211.5 EFE39791.1 - 8.2e-18 63.8 0.4 1.5e-17 63.0 0.4 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EFE39791.1 - 4.1e-16 59.5 0.0 7.1e-16 58.8 0.0 1.5 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFE39791.1 - 7.3e-06 26.2 0.0 0.00015 22.0 0.0 2.2 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone 2-oxoacid_dh PF00198.23 EFE39793.1 - 3.5e-81 272.1 0.0 5e-81 271.6 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFE39793.1 - 2.4e-13 49.7 1.0 2.4e-13 49.7 1.0 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme SAGA-Tad1 PF12767.7 EFE39793.1 - 0.019 14.7 0.7 0.026 14.3 0.7 1.4 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit GCV_H PF01597.19 EFE39793.1 - 0.074 12.9 0.3 0.18 11.7 0.3 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein DUF3614 PF12267.8 EFE39793.1 - 0.19 12.2 1.4 0.25 11.8 0.0 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3614) FAP PF07174.11 EFE39793.1 - 0.36 10.2 14.5 0.56 9.6 14.5 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Presenilin PF01080.17 EFE39793.1 - 0.49 9.1 4.3 0.7 8.6 4.3 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 EFE39793.1 - 8 6.2 11.8 11 5.7 11.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ndc1_Nup PF09531.10 EFE39793.1 - 8 5.0 7.2 10 4.6 7.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Drc1-Sld2 PF11719.8 EFE39794.1 - 1.3e-79 268.9 23.8 1.5e-79 268.7 23.8 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein zf-RING_2 PF13639.6 EFE39795.1 - 4.3e-08 33.4 9.2 7.4e-08 32.6 9.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFE39795.1 - 2e-05 24.3 8.7 3.1e-05 23.8 8.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFE39795.1 - 2.3e-05 24.1 8.7 3.7e-05 23.5 8.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFE39795.1 - 8.5e-05 22.8 8.6 0.00033 20.9 8.6 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFE39795.1 - 0.00011 22.0 8.3 0.00019 21.2 8.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFE39795.1 - 0.017 15.0 6.2 0.027 14.3 6.2 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFE39795.1 - 0.42 10.6 5.1 0.82 9.7 5.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 EFE39795.1 - 0.53 10.1 7.0 1.1 9.0 7.0 1.5 1 0 0 1 1 1 0 RING-like zinc finger HAD_SAK_1 PF10307.9 EFE39797.1 - 9.7e-52 175.7 0.0 1.3e-51 175.3 0.0 1.2 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins DUF4719 PF15843.5 EFE39797.1 - 1.2 9.2 12.1 2.5 8.2 12.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) SWIRM PF04433.17 EFE39798.1 - 3.6e-12 46.4 0.1 1.2e-11 44.8 0.0 1.8 2 0 0 2 2 2 1 SWIRM domain CDC50 PF03381.15 EFE39799.1 - 5.2e-96 321.4 0.0 7.8e-96 320.9 0.0 1.3 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family SPT16 PF08644.11 EFE39800.1 - 1.5e-56 190.7 0.1 3.8e-56 189.5 0.1 1.7 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 EFE39800.1 - 3.1e-55 186.4 0.1 1.3e-54 184.4 0.1 2.2 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 EFE39800.1 - 1.1e-26 93.8 0.0 1.8e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EFE39800.1 - 1.2e-13 51.3 0.1 3.1e-13 49.9 0.0 1.8 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Mito_carr PF00153.27 EFE39801.1 - 1.4e-13 50.6 0.1 1.7e-10 40.7 0.0 3.1 3 0 0 3 3 3 2 Mitochondrial carrier protein IMUP PF15761.5 EFE39802.1 - 0.33 11.7 3.5 0.43 11.3 3.5 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 EFE39802.1 - 6.5 6.3 7.1 8.4 5.9 7.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GST_N_3 PF13417.6 EFE39803.1 - 9.9e-09 35.5 0.0 2e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE39803.1 - 7.4e-08 32.6 0.0 1.4e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFE39803.1 - 3.7e-05 23.8 0.0 6.4e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE39803.1 - 8.5e-05 22.5 0.1 0.00016 21.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFE39803.1 - 0.00024 21.3 0.0 0.0005 20.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DBD_Tnp_Hermes PF10683.9 EFE39803.1 - 0.035 13.8 0.0 0.09 12.5 0.0 1.7 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain PTPRCAP PF15713.5 EFE39804.1 - 1.6 9.0 8.0 1.9 8.8 8.0 1.0 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 EFE39804.1 - 4.6 5.4 8.7 4.9 5.3 8.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Spt5_N PF11942.8 EFE39804.1 - 7 7.7 18.4 8.3 7.5 18.4 1.1 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Sugar_tr PF00083.24 EFE39805.1 - 1e-98 331.1 8.8 1.2e-98 330.9 8.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE39805.1 - 1.6e-30 106.3 20.1 3.6e-30 105.1 14.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFE39805.1 - 1.7e-10 40.1 12.5 1.3e-06 27.3 1.0 2.5 3 0 0 3 3 3 2 MFS/sugar transport protein INSIG PF07281.12 EFE39805.1 - 0.015 14.9 2.1 0.11 12.1 1.9 2.2 2 0 0 2 2 2 0 Insulin-induced protein (INSIG) MFS_1_like PF12832.7 EFE39805.1 - 0.046 12.6 8.1 0.4 9.5 0.1 2.4 1 1 0 2 2 2 0 MFS_1 like family MFS_3 PF05977.13 EFE39805.1 - 0.1 10.9 2.9 0.58 8.5 0.4 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector PepSY_TM_like_2 PF16357.5 EFE39806.1 - 0.044 13.8 0.5 0.05 13.6 0.5 1.2 1 0 0 1 1 1 0 Putative PepSY_TM-like Cwf_Cwc_15 PF04889.12 EFE39806.1 - 0.12 12.1 20.6 0.16 11.6 20.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PMT PF02366.18 EFE39807.1 - 1.8e-88 296.3 14.3 1.8e-88 296.3 14.3 2.4 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EFE39807.1 - 1.1e-64 217.7 17.2 1.1e-64 217.7 17.2 2.1 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EFE39807.1 - 2e-35 122.4 0.2 3.1e-35 121.7 0.2 1.2 1 0 0 1 1 1 1 MIR domain HKR_ArcB_TM PF18415.1 EFE39807.1 - 7.5 7.4 7.8 0.98 10.3 0.5 3.0 2 1 1 3 3 3 0 Histidine kinase receptor ArcB trans-membrane domain Ras PF00071.22 EFE39810.1 - 1.5e-36 125.5 0.0 2.3e-36 124.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE39810.1 - 3.9e-18 65.8 0.0 1e-17 64.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE39810.1 - 1e-07 31.6 0.1 2.3e-07 30.4 0.1 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFE39810.1 - 1.4e-07 31.2 0.0 1.9e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFE39810.1 - 8.8e-05 22.0 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FAM176 PF14851.6 EFE39810.1 - 0.11 12.2 3.1 0.17 11.6 3.1 1.2 1 0 0 1 1 1 0 FAM176 family DUF2868 PF11067.8 EFE39810.1 - 0.13 11.7 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Rrp15p PF07890.12 EFE39810.1 - 0.16 12.3 1.5 0.23 11.8 1.5 1.2 1 0 0 1 1 1 0 Rrp15p CAP_N PF01213.19 EFE39810.1 - 1.8 8.0 7.3 2.5 7.5 0.2 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Choline_transpo PF04515.12 EFE39812.1 - 3.4e-29 102.1 22.2 3.4e-29 102.1 22.2 2.3 2 0 0 2 2 2 1 Plasma-membrane choline transporter EF-hand_8 PF13833.6 EFE39815.1 - 4.1e-31 106.6 5.8 9.7e-13 47.8 0.0 3.9 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 EFE39815.1 - 1.5e-27 93.1 8.5 4.7e-09 35.2 0.0 4.7 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 EFE39815.1 - 1.9e-25 89.1 2.6 1.4e-15 57.5 1.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFE39815.1 - 2.6e-17 61.2 6.5 1.4e-08 34.0 0.0 4.9 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 EFE39815.1 - 1.9e-16 58.7 4.1 1.6e-05 24.1 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EFE39815.1 - 4.3e-10 39.8 0.2 7.5e-05 23.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EFE39815.1 - 7.1e-07 29.1 0.5 0.017 15.1 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 EFE39815.1 - 3.1e-06 27.1 0.3 0.0099 15.9 0.1 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) RNA_pol_Rpb4 PF03874.16 EFE39815.1 - 0.0011 19.3 0.9 0.98 9.8 0.2 2.5 2 1 0 2 2 2 2 RNA polymerase Rpb4 SPARC_Ca_bdg PF10591.9 EFE39815.1 - 0.0012 19.2 0.1 0.18 12.1 0.1 2.2 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.10 EFE39815.1 - 0.0026 17.8 0.1 0.0078 16.3 0.0 1.9 2 0 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 EFE39815.1 - 0.018 15.9 0.1 0.25 12.2 0.1 2.1 1 1 1 2 2 2 0 EF-hand domain RuvA_C PF07499.13 EFE39815.1 - 0.065 13.7 0.1 14 6.2 0.0 3.6 4 0 0 4 4 4 0 RuvA, C-terminal domain DUF5580 PF17743.1 EFE39815.1 - 0.084 11.4 0.0 0.1 11.1 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Poly_export PF02563.16 EFE39815.1 - 0.15 12.3 0.1 0.4 11.0 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis/export protein Dockerin_1 PF00404.18 EFE39815.1 - 1.5 9.1 4.7 3 8.1 0.8 2.6 1 1 2 3 3 3 0 Dockerin type I domain Med20 PF08612.11 EFE39816.1 - 7.4e-55 185.7 0.0 9.5e-55 185.4 0.0 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex FAD_binding_1 PF00667.20 EFE39817.1 - 2.1e-44 151.8 0.0 2.9e-44 151.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EFE39817.1 - 4e-09 37.1 0.0 1.4e-08 35.4 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain ChaC PF04752.12 EFE39818.1 - 2.4e-28 99.4 0.0 4.4e-28 98.5 0.0 1.3 1 1 0 1 1 1 1 ChaC-like protein RRM_1 PF00076.22 EFE39819.1 - 8.2e-15 54.4 0.1 3.3e-14 52.5 0.1 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cytochrome_P460 PF16694.5 EFE39819.1 - 0.11 12.8 0.8 0.19 12.1 0.0 1.7 2 0 0 2 2 2 0 Cytochrome P460 FHA PF00498.26 EFE39820.1 - 3.5e-10 40.1 0.2 6.2e-10 39.3 0.2 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFE39820.1 - 0.0034 17.7 0.1 0.0057 16.9 0.1 1.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Methyltransf_23 PF13489.6 EFE39822.1 - 2.4e-13 50.3 0.0 4.4e-13 49.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE39822.1 - 0.025 15.3 0.0 0.88 10.3 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain ApoO PF09769.9 EFE39823.1 - 0.13 12.2 0.2 0.7 9.9 0.0 2.0 2 0 0 2 2 2 0 Apolipoprotein O CAF1A PF12253.8 EFE39824.1 - 5.3e-22 77.8 4.6 5.3e-22 77.8 4.6 3.8 2 1 0 2 2 1 1 Chromatin assembly factor 1 subunit A Caldesmon PF02029.15 EFE39824.1 - 5.1e-05 22.2 34.4 8.6e-05 21.5 34.4 1.3 1 0 0 1 1 1 1 Caldesmon CAF-1_p150 PF11600.8 EFE39824.1 - 0.0011 18.7 61.2 0.002 17.9 61.2 1.3 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Asp-B-Hydro_N PF05279.11 EFE39824.1 - 0.4 10.7 36.6 0.82 9.7 36.6 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.17 EFE39824.1 - 0.47 9.2 23.9 0.85 8.3 23.9 1.5 1 0 0 1 1 1 0 Presenilin Mitofilin PF09731.9 EFE39824.1 - 0.61 8.9 37.1 0.94 8.2 37.1 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Mem_trans PF03547.18 EFE39824.1 - 0.97 7.8 2.8 1.3 7.3 2.8 1.3 1 0 0 1 1 1 0 Membrane transport protein MCM_bind PF09739.9 EFE39824.1 - 1.1 7.6 20.4 1.9 6.9 20.4 1.5 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor AAA_11 PF13086.6 EFE39824.1 - 3.7 7.3 20.8 7.1 6.3 20.8 1.5 1 0 0 1 1 1 0 AAA domain LAP1C PF05609.12 EFE39824.1 - 6.2 5.8 25.2 11 5.0 25.2 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CNDH2_C PF16858.5 EFE39824.1 - 7 6.4 36.2 5.6 6.8 25.0 3.1 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Peptidase_S64 PF08192.11 EFE39824.1 - 9.1 4.6 19.9 17 3.8 19.9 1.4 1 0 0 1 1 1 0 Peptidase family S64 Swm2 PF17083.5 EFE39825.1 - 0.049 13.6 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Nucleolar protein Swm2 BAR PF03114.18 EFE39825.1 - 0.072 12.7 0.5 0.42 10.2 0.7 2.1 2 0 0 2 2 2 0 BAR domain IPP-2 PF04979.14 EFE39826.1 - 5.1e-20 72.6 17.4 5.1e-20 72.6 17.4 2.4 2 1 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) CRAL_TRIO PF00650.20 EFE39828.1 - 1.2e-12 47.9 0.0 2e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFE39828.1 - 4.4e-10 39.6 0.2 1.3e-09 38.1 0.0 1.9 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain BASP1 PF05466.12 EFE39828.1 - 1.2 9.1 60.1 1.2 9.2 26.3 2.2 2 0 0 2 2 2 0 Brain acid soluble protein 1 (BASP1 protein) TAF6_C PF07571.13 EFE39829.1 - 1.4e-30 105.5 0.0 3.1e-30 104.3 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EFE39829.1 - 4.8e-25 87.5 0.0 2e-24 85.5 0.0 2.1 3 0 0 3 3 3 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 EFE39829.1 - 0.0015 18.6 0.1 0.0043 17.1 0.1 1.7 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 EFE39829.1 - 0.0094 16.3 0.0 0.023 15.1 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EFE39829.1 - 0.0096 15.9 0.0 0.023 14.7 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 EFE39829.1 - 0.061 13.6 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF4 PF05236.14 EFE39829.1 - 0.12 12.1 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Rota_NS35 PF02509.14 EFE39829.1 - 0.17 10.9 0.1 0.24 10.4 0.1 1.2 1 0 0 1 1 1 0 Rotavirus non-structural protein 35 SAM_decarbox PF01536.16 EFE39830.1 - 2.4e-130 434.7 0.0 2.8e-130 434.5 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Pkinase PF00069.25 EFE39832.1 - 2.9e-41 141.6 0.0 4.8e-40 137.6 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39832.1 - 4.3e-23 81.9 0.0 7e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE39832.1 - 0.038 13.9 0.1 0.062 13.2 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family UPF0449 PF15136.6 EFE39832.1 - 0.13 12.7 0.2 0.41 11.1 0.2 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 AMP-binding PF00501.28 EFE39833.1 - 1.7e-210 699.0 0.0 1.4e-78 264.4 0.0 4.3 3 1 1 4 4 4 4 AMP-binding enzyme Condensation PF00668.20 EFE39833.1 - 4.3e-189 628.9 0.0 1.3e-40 139.5 0.0 6.7 6 1 0 6 6 6 6 Condensation domain PP-binding PF00550.25 EFE39833.1 - 1.5e-55 185.5 17.3 1.7e-09 37.9 0.1 7.0 6 0 0 6 6 6 6 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE39833.1 - 1.1e-12 48.7 0.0 5.1e-06 27.4 0.0 3.9 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain K_oxygenase PF13434.6 EFE39834.1 - 1.3e-108 363.2 0.0 1.5e-108 363.0 0.0 1.1 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFE39834.1 - 3.2e-06 27.2 0.0 0.00019 21.5 0.0 2.6 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFE39834.1 - 1.1e-05 24.8 0.0 0.0061 15.8 0.0 2.6 2 2 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE39834.1 - 0.00031 20.1 0.0 0.066 12.5 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DHHC PF01529.20 EFE39835.1 - 7.7e-36 123.2 10.2 7.7e-36 123.2 10.2 2.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EFE39835.1 - 1e-26 93.3 0.0 6.9e-11 42.6 0.0 3.8 2 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFE39835.1 - 3.2e-25 87.9 0.2 1.6e-08 34.7 0.0 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE39835.1 - 7.9e-23 78.1 2.6 1.2e-07 31.5 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EFE39835.1 - 8.6e-22 77.2 1.5 1.6e-06 28.5 0.0 5.1 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EFE39835.1 - 4.9e-20 71.0 0.0 4e-06 27.0 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeat OB_NTP_bind PF07717.16 EFE39836.1 - 2.3e-21 75.9 0.0 5.8e-21 74.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EFE39836.1 - 2.3e-19 69.6 0.0 2.3e-19 69.6 0.0 3.3 4 0 0 4 4 4 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFE39836.1 - 2.8e-13 50.2 0.0 6.1e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE39836.1 - 7.3e-06 25.9 0.0 1.5e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase PWI PF01480.17 EFE39836.1 - 8.1e-06 26.1 0.0 2.2e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 PWI domain AAA_22 PF13401.6 EFE39836.1 - 2.1e-05 24.8 0.0 0.00012 22.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFE39836.1 - 0.00036 20.3 0.1 0.00089 19.0 0.1 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFE39836.1 - 0.0025 16.9 0.0 0.0052 15.9 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EFE39836.1 - 0.0026 18.1 0.1 0.0054 17.1 0.1 1.5 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EFE39836.1 - 0.016 14.9 0.2 0.039 13.6 0.2 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Sigma54_activ_2 PF14532.6 EFE39836.1 - 0.038 14.1 0.0 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_23 PF13476.6 EFE39836.1 - 0.098 13.2 0.0 0.098 13.2 0.0 3.5 1 1 2 3 3 1 0 AAA domain AAA_7 PF12775.7 EFE39836.1 - 0.16 11.5 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 EFE39836.1 - 0.16 12.3 1.4 0.25 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 EFE39836.1 - 1.3 9.6 4.2 0.52 10.8 0.2 2.4 2 1 1 3 3 2 0 ABC transporter Cyt-b5 PF00173.28 EFE39837.1 - 1.6e-20 73.0 0.1 1.8e-20 72.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF4430 PF14478.6 EFE39837.1 - 0.076 13.6 0.1 0.11 13.1 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4430) V-ATPase_H_C PF11698.8 EFE39837.1 - 0.11 12.7 0.0 0.34 11.0 0.0 1.8 1 1 1 2 2 2 0 V-ATPase subunit H DUF4291 PF14124.6 EFE39838.1 - 1.7e-72 243.1 0.1 1.9e-72 242.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) Mcp5_PH PF12814.7 EFE39839.1 - 5.3e-46 155.7 1.1 6.2e-46 155.5 0.0 1.7 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology Fez1 PF06818.15 EFE39839.1 - 0.0041 17.6 13.1 0.0041 17.6 11.8 1.6 1 1 0 1 1 1 1 Fez1 DUF3584 PF12128.8 EFE39839.1 - 0.08 10.5 11.3 0.11 10.0 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.12 EFE39839.1 - 0.26 11.4 17.1 0.65 10.1 8.2 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF724 PF05266.14 EFE39839.1 - 0.35 10.7 2.4 0.63 9.8 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Lebercilin PF15619.6 EFE39839.1 - 1.2 8.8 12.0 2 8.0 12.0 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease MFS_1 PF07690.16 EFE39840.1 - 1.5e-09 37.3 34.2 1.5e-09 37.3 34.2 4.3 2 2 1 3 3 3 2 Major Facilitator Superfamily Chloroa_b-bind PF00504.21 EFE39840.1 - 3.5 8.2 5.7 0.5 10.9 0.2 2.4 3 0 0 3 3 3 0 Chlorophyll A-B binding protein Ribonuc_red_lgC PF02867.15 EFE39841.1 - 5.9e-187 622.3 0.0 7.9e-187 621.9 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EFE39841.1 - 8.1e-26 89.9 0.0 1.8e-25 88.8 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EFE39841.1 - 5.9e-13 49.2 0.1 2.2e-12 47.4 0.0 2.0 2 0 0 2 2 2 1 ATP cone domain PRK PF00485.18 EFE39843.1 - 0.00018 21.3 0.0 0.00025 20.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EFE39843.1 - 0.00026 21.5 0.1 0.014 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFE39843.1 - 0.0016 18.6 0.4 0.3 11.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EFE39843.1 - 0.0031 17.9 0.0 0.0047 17.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 EFE39843.1 - 0.015 15.7 0.1 1.1 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 EFE39843.1 - 0.034 13.8 0.0 1.8 8.2 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase DUF463 PF04317.12 EFE39843.1 - 0.04 12.8 0.0 0.05 12.5 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 AAA_16 PF13191.6 EFE39843.1 - 0.1 13.0 0.1 0.13 12.6 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EFE39843.1 - 0.11 11.6 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain APS_kinase PF01583.20 EFE39843.1 - 0.17 11.7 0.0 0.36 10.7 0.0 1.5 2 0 0 2 2 2 0 Adenylylsulphate kinase MeaB PF03308.16 EFE39843.1 - 0.2 10.6 0.0 0.33 9.9 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF5582 PF17819.1 EFE39844.1 - 1.4 9.3 5.6 0.61 10.5 3.2 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5582) Mur_ligase_M PF08245.12 EFE39845.1 - 1.3e-06 28.5 0.0 2.5e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 EFE39845.1 - 0.065 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Pkinase PF00069.25 EFE39846.1 - 4.4e-57 193.4 0.0 1.7e-56 191.5 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39846.1 - 1.1e-39 136.2 0.0 3e-39 134.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE39846.1 - 0.0037 16.1 0.0 0.0078 15.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase GerD PF17898.1 EFE39846.1 - 0.16 11.9 1.1 0.41 10.6 1.1 1.7 1 0 0 1 1 1 0 Spore germination GerD central core domain Peptidase_M24 PF00557.24 EFE39847.1 - 2.7e-42 144.8 0.0 3.3e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Pectinesterase PF01095.19 EFE39847.1 - 0.13 11.0 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Pectinesterase Casc1 PF12366.8 EFE39847.1 - 0.17 11.4 1.1 0.31 10.5 1.1 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 PGA2 PF07543.12 EFE39847.1 - 0.39 10.7 9.0 0.76 9.8 9.0 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 CDC45 PF02724.14 EFE39847.1 - 1.2 7.4 7.3 1.7 6.9 7.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3381 PF11861.8 EFE39847.1 - 2 8.2 10.5 3.8 7.3 10.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DnaJ PF00226.31 EFE39848.1 - 8.2e-13 48.3 0.4 1.6e-12 47.4 0.4 1.5 1 0 0 1 1 1 1 DnaJ domain Porin_3 PF01459.22 EFE39849.1 - 4.1e-68 229.8 4.4 5e-68 229.5 4.4 1.0 1 0 0 1 1 1 1 Eukaryotic porin PA PF02225.22 EFE39850.1 - 0.0027 17.7 0.4 0.003 17.5 0.4 1.2 1 0 0 1 1 1 1 PA domain Asn_synthase PF00733.21 EFE39851.1 - 8.9e-85 285.5 0.1 2.2e-52 178.9 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EFE39851.1 - 3.1e-36 124.0 0.0 7e-36 122.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EFE39851.1 - 2.7e-26 92.3 0.0 4.6e-26 91.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EFE39851.1 - 1.3e-06 28.1 0.0 2.5e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EFE39851.1 - 0.0018 17.5 0.1 0.0089 15.2 0.1 1.9 1 1 0 1 1 1 1 NAD synthase G-patch PF01585.23 EFE39852.1 - 6e-12 45.3 1.0 1.1e-11 44.5 1.0 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFE39852.1 - 0.028 14.5 0.1 0.086 12.9 0.1 1.8 1 0 0 1 1 1 0 G-patch domain Mac PF12464.8 EFE39852.1 - 0.052 13.8 1.3 0.15 12.3 0.7 2.0 2 0 0 2 2 2 0 Maltose acetyltransferase HsbA PF12296.8 EFE39852.1 - 0.12 12.8 0.1 0.23 11.9 0.1 1.4 1 0 0 1 1 1 0 Hydrophobic surface binding protein A AMP-binding PF00501.28 EFE39853.1 - 7.3e-89 298.3 0.0 8.6e-89 298.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE39853.1 - 3.5e-07 31.1 0.1 8.1e-07 29.9 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EFE39853.1 - 2.6e-06 26.6 0.1 0.00042 19.3 0.0 2.9 3 0 0 3 3 3 1 GH3 auxin-responsive promoter RTX_C PF08339.10 EFE39853.1 - 0.0084 16.2 0.0 0.023 14.8 0.1 1.7 2 0 0 2 2 2 1 RTX C-terminal domain Fungal_trans PF04082.18 EFE39854.1 - 1.6e-14 53.6 0.7 8.8e-14 51.2 0.7 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.8 EFE39855.1 - 3.1e-09 36.1 0.1 3.1e-08 32.9 0.0 2.3 2 1 0 2 2 2 1 Fungal specific transcription factor domain Rad10 PF03834.14 EFE39856.1 - 4.6e-48 162.0 0.0 6.5e-48 161.5 0.0 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EFE39856.1 - 0.00053 20.5 0.0 0.0012 19.4 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 EFE39856.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH PF00633.23 EFE39856.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif RRM_1 PF00076.22 EFE39857.1 - 8.3e-60 198.5 0.0 1.9e-18 66.0 0.0 5.5 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EFE39857.1 - 1.7e-07 31.6 1.4 2.7 8.2 0.0 5.5 4 3 3 7 7 7 3 Cytosolic domain of 10TM putative phosphate transporter RRM_Rrp7 PF17799.1 EFE39857.1 - 3.9e-05 23.5 0.1 0.43 10.4 0.0 3.4 2 1 1 3 3 3 2 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 EFE39857.1 - 0.00061 19.9 0.0 6.1 7.0 0.0 3.9 3 0 0 3 3 3 1 RNA recognition motif RRM_5 PF13893.6 EFE39857.1 - 0.0094 15.6 0.0 3.8 7.1 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1980 PF09323.10 EFE39857.1 - 0.39 10.6 0.7 2.3 8.1 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) Cyt-b5 PF00173.28 EFE39858.1 - 1.1e-08 35.1 0.0 1.2e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AA_permease PF00324.21 EFE39859.1 - 6.3e-94 315.2 28.1 7.7e-94 315.0 28.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE39859.1 - 3.4e-14 52.5 29.2 4e-14 52.3 29.2 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.11 EFE39859.1 - 0.014 15.7 2.1 0.014 15.7 2.1 3.4 2 1 1 4 4 4 0 Domain of unknown function (DUF1772) Cupin_8 PF13621.6 EFE39860.1 - 4e-20 72.6 0.0 2.1e-19 70.2 0.0 1.8 2 0 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.12 EFE39860.1 - 2.8e-05 23.7 0.0 6.1e-05 22.6 0.0 1.5 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_2 PF07883.11 EFE39860.1 - 0.0084 15.8 0.0 0.027 14.2 0.0 1.9 2 0 0 2 2 2 1 Cupin domain JmjC PF02373.22 EFE39860.1 - 0.017 15.6 0.0 0.073 13.5 0.0 2.1 3 0 0 3 3 3 0 JmjC domain, hydroxylase Fungal_trans PF04082.18 EFE39861.1 - 2.2e-17 63.0 0.0 3.9e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MscS_porin PF12795.7 EFE39861.1 - 0.19 11.3 0.2 0.27 10.7 0.2 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain CK_II_beta PF01214.18 EFE39862.1 - 5.4e-75 251.2 0.0 1e-74 250.3 0.0 1.4 1 1 0 1 1 1 1 Casein kinase II regulatory subunit Spt5_N PF11942.8 EFE39862.1 - 0.032 15.2 5.6 0.032 15.2 5.6 2.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal RRN3 PF05327.11 EFE39862.1 - 0.079 11.5 1.3 0.11 11.0 1.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PTPRCAP PF15713.5 EFE39862.1 - 6.4 7.1 6.9 21 5.4 5.2 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Aminotran_4 PF01063.19 EFE39864.1 - 3.1e-23 82.8 0.0 3.8e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Ank_2 PF12796.7 EFE39865.1 - 8.1e-33 112.9 8.3 4.4e-10 40.0 0.0 4.0 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE39865.1 - 2.6e-26 91.6 4.7 5.2e-09 36.5 0.0 5.8 2 1 6 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE39865.1 - 6.1e-16 56.9 5.0 0.057 14.0 0.0 7.2 6 0 0 6 6 6 4 Ankyrin repeat GDPD PF03009.17 EFE39865.1 - 3.1e-13 50.1 0.0 8.9e-13 48.6 0.0 1.7 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_5 PF13857.6 EFE39865.1 - 2.7e-12 46.6 2.8 0.14 12.6 0.0 5.7 2 1 3 6 6 6 4 Ankyrin repeats (many copies) SPX PF03105.19 EFE39865.1 - 3.1e-11 43.8 15.0 2e-05 24.7 1.4 3.8 3 1 1 4 4 4 3 SPX domain Ank PF00023.30 EFE39865.1 - 7.5e-08 32.5 9.4 0.15 12.5 0.1 6.8 7 0 0 7 7 7 2 Ankyrin repeat Ebp2 PF05890.12 EFE39865.1 - 0.49 9.9 3.1 1.1 8.8 3.1 1.4 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 Pkinase PF00069.25 EFE39866.1 - 1.5e-18 67.1 0.0 6.1e-18 65.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39866.1 - 9e-09 35.0 0.0 5.8e-08 32.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Peptidase_M49 PF03571.15 EFE39867.1 - 9.9e-244 809.8 0.0 2e-243 808.8 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M49 HAUS-augmin3 PF14932.6 EFE39868.1 - 0.018 14.6 1.2 0.99 8.9 0.2 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 RICTOR_phospho PF14665.6 EFE39868.1 - 0.023 15.0 1.3 0.82 10.0 0.0 3.0 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, phosphorylation-site DUF3060 PF11259.8 EFE39868.1 - 0.074 12.8 0.5 1.2 8.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3060) PDDEXK_6 PF04720.12 EFE39868.1 - 0.2 11.6 0.1 0.2 11.6 0.1 1.7 2 0 0 2 2 2 0 PDDEXK-like family of unknown function SNF5 PF04855.12 EFE39870.1 - 9.5e-82 274.3 0.0 1.2e-81 274.0 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 BHD_1 PF10403.9 EFE39871.1 - 0.027 14.3 0.0 0.067 13.0 0.0 1.6 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 1 WD40 PF00400.32 EFE39872.1 - 2.5e-19 69.3 19.7 7.6e-05 23.4 0.7 7.2 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39872.1 - 6.3e-10 39.2 5.4 0.00012 22.4 0.2 4.3 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EFE39872.1 - 0.00024 21.1 10.3 0.17 11.8 4.5 2.8 1 1 0 2 2 2 2 Transcription factor IIIC subunit delta N-term SNARE PF05739.19 EFE39873.1 - 8.9e-05 22.4 0.1 0.00027 20.9 0.1 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EFE39873.1 - 0.001 18.8 8.2 0.037 13.7 0.5 2.1 2 0 0 2 2 2 2 Syntaxin MCPsignal PF00015.21 EFE39873.1 - 0.027 14.3 0.8 0.027 14.3 0.8 2.5 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CTD_bind PF04818.13 EFE39874.1 - 2.1e-17 63.7 0.1 1.1e-16 61.3 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase II-binding domain. YscO-like PF16789.5 EFE39874.1 - 0.07 13.2 1.0 0.15 12.1 1.0 1.5 1 0 0 1 1 1 0 YscO-like protein MCD_N PF17408.2 EFE39874.1 - 0.12 12.5 0.7 4.4 7.5 0.0 3.4 4 0 0 4 4 4 0 Malonyl-CoA decarboxylase N-terminal domain CTK3 PF12243.8 EFE39874.1 - 0.13 12.3 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 YjcZ PF13990.6 EFE39874.1 - 0.23 10.8 2.9 9.6 5.5 0.4 2.3 2 0 0 2 2 2 0 YjcZ-like protein SKA2 PF16740.5 EFE39874.1 - 5.7 6.8 7.2 4.7 7.0 1.8 2.9 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Clathrin_lg_ch PF01086.17 EFE39875.1 - 3.3e-74 249.8 4.0 3.7e-74 249.7 4.0 1.0 1 0 0 1 1 1 1 Clathrin light chain Acyl_transf_3 PF01757.22 EFE39876.1 - 1.5e-19 70.3 33.4 2.1e-19 69.8 33.4 1.2 1 0 0 1 1 1 1 Acyltransferase family Mannosyl_trans3 PF11051.8 EFE39877.1 - 2e-56 191.4 0.0 2.6e-32 112.3 0.0 2.1 1 1 1 2 2 2 2 Mannosyltransferase putative CDC37_N PF03234.14 EFE39878.1 - 1.5e-50 171.4 2.1 1.5e-50 171.4 2.1 3.2 3 1 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EFE39878.1 - 1.5e-41 141.1 0.4 5.1e-41 139.3 0.1 2.1 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EFE39878.1 - 1.5e-34 118.1 3.7 1.5e-34 118.1 3.7 2.2 3 0 0 3 3 3 1 Cdc37 C terminal domain MecA_N PF05223.11 EFE39878.1 - 0.0021 18.3 2.0 0.0038 17.5 0.5 2.2 2 0 0 2 2 2 1 NTF2-like N-terminal transpeptidase domain Thiamine_BP PF01910.17 EFE39878.1 - 0.068 13.1 0.3 0.28 11.1 0.0 2.1 2 0 0 2 2 2 0 Thiamine-binding protein DUF3573 PF12097.8 EFE39878.1 - 0.16 10.7 0.5 0.27 10.0 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF2680 PF10925.8 EFE39878.1 - 0.5 10.4 3.7 5.5 7.1 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) ABC_membrane PF00664.23 EFE39879.1 - 1.6e-52 178.9 10.5 2.1e-52 178.5 10.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFE39879.1 - 3.7e-35 121.4 0.0 1e-34 120.0 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFE39879.1 - 6.8e-07 28.9 0.1 5e-05 22.8 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFE39879.1 - 0.00017 22.0 0.1 0.00078 19.9 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFE39879.1 - 0.0029 17.9 0.1 0.02 15.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFE39879.1 - 0.0062 16.3 0.5 0.018 14.8 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA PF00004.29 EFE39879.1 - 0.013 15.9 0.0 0.071 13.5 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EFE39879.1 - 0.031 14.0 0.2 0.5 10.1 0.0 2.5 2 1 1 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 EFE39879.1 - 0.044 13.5 0.0 0.14 11.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFE39879.1 - 0.045 13.3 0.0 0.47 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EFE39879.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ABC_ATPase PF09818.9 EFE39879.1 - 0.11 11.2 0.7 0.29 9.9 0.2 1.8 2 0 0 2 2 2 0 Predicted ATPase of the ABC class Sigma54_activ_2 PF14532.6 EFE39879.1 - 0.13 12.4 0.0 0.59 10.2 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_5 PF07728.14 EFE39879.1 - 0.13 12.3 0.1 0.89 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 EFE39879.1 - 0.41 10.9 1.9 2.8 8.2 0.7 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Nucleoside_tran PF01733.18 EFE39880.1 - 6.2e-40 137.5 14.0 1.2e-38 133.3 11.7 2.8 1 1 1 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 EFE39880.1 - 1.9e-06 27.1 32.9 3e-05 23.1 31.3 2.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Ac76 PF05814.11 EFE39880.1 - 0.12 12.4 2.2 0.62 10.1 0.2 2.6 2 0 0 2 2 2 0 Orf76 (Ac76) Gate PF07670.14 EFE39880.1 - 4.4 7.6 8.4 1.3 9.3 3.4 2.7 2 0 0 2 2 2 0 Nucleoside recognition COX7C PF02935.16 EFE39880.1 - 7.6 6.9 7.0 16 5.9 0.7 3.1 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc Metallophos_2 PF12850.7 EFE39881.1 - 1e-09 38.8 0.0 6.1e-08 33.0 0.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EFE39881.1 - 1.6e-09 38.6 0.0 3.1e-09 37.6 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Haspin_kinase PF12330.8 EFE39882.1 - 6e-40 137.3 0.0 2.8e-39 135.1 0.0 2.1 1 1 1 2 2 2 1 Haspin like kinase domain DUF1682 PF07946.14 EFE39884.1 - 2e-113 378.9 2.8 2.3e-113 378.7 2.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF3619 PF12279.8 EFE39884.1 - 0.024 15.0 0.6 8.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) PPR_3 PF13812.6 EFE39885.1 - 0.013 15.6 0.0 0.037 14.1 0.0 1.8 1 0 0 1 1 1 0 Pentatricopeptide repeat domain SYF2 PF08231.12 EFE39887.1 - 6.3e-49 166.4 17.4 6.3e-49 166.4 17.4 2.2 2 0 0 2 2 2 1 SYF2 splicing factor ARD PF03079.14 EFE39887.1 - 0.023 14.9 1.0 0.023 14.9 1.0 3.5 2 1 1 3 3 3 0 ARD/ARD' family POT1PC PF16686.5 EFE39887.1 - 0.78 9.6 7.9 0.31 10.9 0.5 2.9 3 0 0 3 3 3 0 ssDNA-binding domain of telomere protection protein DUF1797 PF08796.10 EFE39887.1 - 1.9 8.6 5.0 0.6 10.2 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1797) Ndc1_Nup PF09531.10 EFE39887.1 - 9.6 4.8 8.5 12 4.5 8.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NAD_binding_10 PF13460.6 EFE39888.1 - 0.026 14.4 0.0 0.15 12.0 0.0 2.2 1 1 0 1 1 1 0 NAD(P)H-binding Pox_RNA_Pol_19 PF05320.12 EFE39888.1 - 0.059 13.3 0.0 0.096 12.7 0.0 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit NAD_binding_4 PF07993.12 EFE39888.1 - 0.088 12.0 2.7 0.92 8.6 0.1 3.0 2 1 0 2 2 2 0 Male sterility protein SMRP1 PF15181.6 EFE39888.1 - 0.098 12.2 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 YEATS PF03366.16 EFE39889.1 - 1.4e-36 124.3 0.7 2.1e-36 123.7 0.7 1.3 1 0 0 1 1 1 1 YEATS family YebG PF07130.12 EFE39889.1 - 0.12 12.3 0.2 0.4 10.6 0.2 1.8 2 0 0 2 2 2 0 YebG protein Rep_fac_C PF08542.11 EFE39890.1 - 1.8e-24 86.0 0.1 5.9e-24 84.3 0.0 1.9 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EFE39890.1 - 4.9e-12 45.9 0.0 1.2e-10 41.4 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EFE39890.1 - 9.1e-10 39.1 0.0 1.6e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFE39890.1 - 4.1e-06 27.3 0.0 6.3e-05 23.4 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EFE39890.1 - 5.1e-06 26.6 0.0 1.1e-05 25.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFE39890.1 - 3.6e-05 23.6 0.0 0.00011 22.0 0.0 1.9 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFE39890.1 - 5.8e-05 23.4 0.1 0.0002 21.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 EFE39890.1 - 0.00018 21.4 0.0 0.0003 20.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Viral_helicase1 PF01443.18 EFE39890.1 - 0.00099 18.9 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EFE39890.1 - 0.0026 17.2 0.0 0.027 13.9 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI TniB PF05621.11 EFE39890.1 - 0.0039 16.6 0.0 0.017 14.5 0.0 1.9 1 1 0 1 1 1 1 Bacterial TniB protein AAA_assoc_2 PF16193.5 EFE39890.1 - 0.0039 17.5 0.0 0.016 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA C-terminal domain Rad17 PF03215.15 EFE39890.1 - 0.0091 15.9 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain MeaB PF03308.16 EFE39890.1 - 0.011 14.8 0.0 0.018 14.0 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EFE39890.1 - 0.014 15.2 0.0 0.082 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EFE39890.1 - 0.014 15.2 0.1 0.097 12.5 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.10 EFE39890.1 - 0.019 14.4 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DEAD PF00270.29 EFE39890.1 - 0.024 14.4 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase NTPase_1 PF03266.15 EFE39890.1 - 0.024 14.5 0.1 0.081 12.8 0.0 1.8 2 0 0 2 2 2 0 NTPase AAA_11 PF13086.6 EFE39890.1 - 0.034 13.9 0.0 0.055 13.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EFE39890.1 - 0.064 13.6 0.1 0.68 10.3 0.1 2.2 1 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EFE39890.1 - 0.082 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EFE39890.1 - 0.12 12.0 0.0 0.39 10.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain His_Phos_2 PF00328.22 EFE39891.1 - 0.017 14.5 0.0 0.038 13.3 0.0 1.5 1 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) DUF1338 PF07063.13 EFE39892.1 - 7.6e-105 350.7 0.0 9e-105 350.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) DUF410 PF04190.13 EFE39894.1 - 5.8e-87 291.7 0.0 6.9e-87 291.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) RAI1 PF08652.11 EFE39895.1 - 1.2e-27 95.8 0.0 2.3e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Glyco_hydro_57 PF03065.15 EFE39895.1 - 0.048 12.8 0.0 0.057 12.6 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 CEP76-C2 PF15627.6 EFE39895.1 - 0.07 12.7 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 CEP76 C2 domain IPPT PF01715.17 EFE39896.1 - 2.3e-62 210.8 0.2 3.9e-62 210.0 0.2 1.3 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 EFE39896.1 - 8.8e-05 22.0 0.6 0.0002 20.8 0.0 1.8 2 1 0 2 2 2 1 Isopentenyl transferase AAA_33 PF13671.6 EFE39896.1 - 0.0001 22.5 0.7 0.27 11.4 0.0 3.1 3 0 0 3 3 3 2 AAA domain zf-met PF12874.7 EFE39896.1 - 0.00033 20.9 0.0 0.0006 20.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFE39896.1 - 0.0023 18.3 0.8 0.0078 16.5 0.1 2.1 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) AAA_18 PF13238.6 EFE39896.1 - 0.0032 18.0 1.6 1.5 9.4 0.0 3.1 2 1 1 3 3 3 2 AAA domain zf-C2H2_jaz PF12171.8 EFE39896.1 - 0.006 16.8 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding AAA_25 PF13481.6 EFE39896.1 - 0.017 14.7 0.4 0.1 12.2 0.1 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EFE39896.1 - 0.14 11.6 0.1 0.28 10.6 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein DUF87 PF01935.17 EFE39896.1 - 0.17 12.0 3.9 1.2 9.2 0.1 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain DUF3811 PF11656.8 EFE39896.1 - 2.9 8.3 7.2 6.8 7.1 0.1 3.1 3 0 0 3 3 3 0 YjbD family (DUF3811) ABC_tran PF00005.27 EFE39897.1 - 3.8e-16 59.8 0.1 2e-15 57.5 0.1 2.0 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFE39897.1 - 2.5e-10 40.7 2.1 0.00011 22.2 0.2 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFE39897.1 - 7.1e-05 22.4 0.0 0.21 11.0 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFE39897.1 - 8e-05 22.3 0.2 0.00018 21.2 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EFE39897.1 - 0.00046 20.0 0.1 0.0007 19.4 0.1 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 EFE39897.1 - 0.0011 19.5 0.1 0.0017 18.9 0.1 1.2 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFE39897.1 - 0.006 16.5 0.0 0.0093 15.9 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase DUF3584 PF12128.8 EFE39897.1 - 0.023 12.3 0.1 0.03 11.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_25 PF13481.6 EFE39897.1 - 0.038 13.6 0.0 0.078 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFE39897.1 - 0.042 14.2 0.9 0.094 13.1 0.9 1.7 1 1 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 EFE39897.1 - 0.048 13.7 0.2 0.49 10.4 0.1 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_28 PF13521.6 EFE39897.1 - 0.061 13.6 0.2 0.15 12.3 0.2 1.6 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EFE39897.1 - 0.066 13.3 0.3 0.13 12.4 0.3 1.4 1 0 0 1 1 1 0 Dynamin family MMR_HSR1 PF01926.23 EFE39897.1 - 0.078 13.1 0.3 0.15 12.1 0.3 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EFE39897.1 - 0.082 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_27 PF13514.6 EFE39897.1 - 0.089 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.7 EFE39897.1 - 0.13 11.2 0.0 0.31 9.9 0.0 1.5 1 1 1 2 2 2 0 AAA-like domain Zeta_toxin PF06414.12 EFE39897.1 - 0.22 10.8 0.0 0.33 10.2 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin PduV-EutP PF10662.9 EFE39897.1 - 0.25 11.1 0.0 0.4 10.4 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation WD40 PF00400.32 EFE39898.1 - 6.3e-31 106.0 28.7 4.7e-05 24.1 0.0 12.1 13 0 0 13 13 13 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39898.1 - 6.5e-05 23.2 2.2 45 4.4 0.0 6.7 7 2 2 9 9 9 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4596 PF15363.6 EFE39898.1 - 0.1 12.8 0.7 0.48 10.7 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4596) Urm1 PF09138.11 EFE39899.1 - 3.5e-09 36.9 0.0 5.3e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) 6PF2K PF01591.18 EFE39900.1 - 5.5e-24 84.7 1.3 1.1e-11 44.4 0.3 2.8 1 1 1 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EFE39900.1 - 6.4e-20 71.7 0.0 3e-19 69.5 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Porin_3 PF01459.22 EFE39901.1 - 2e-81 273.4 0.0 2.3e-81 273.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Zds_C PF08632.10 EFE39901.1 - 0.017 14.8 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term Qn_am_d_aII PF14930.6 EFE39901.1 - 0.13 12.6 0.1 0.26 11.6 0.1 1.5 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain II 2OG-FeII_Oxy_2 PF13532.6 EFE39903.1 - 2e-24 86.9 0.0 9.5e-24 84.7 0.0 2.2 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Chromo PF00385.24 EFE39903.1 - 0.0018 18.2 0.7 0.0042 17.0 0.2 2.0 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain AMP-binding PF00501.28 EFE39904.1 - 1.9e-75 254.1 0.1 1.6e-73 247.7 0.1 2.0 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE39904.1 - 4e-14 53.3 0.4 1e-13 52.0 0.4 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain WD40 PF00400.32 EFE39905.1 - 7.2e-19 67.8 9.0 0.0037 18.1 0.0 8.4 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE39905.1 - 8.1e-07 29.3 0.0 0.0011 19.2 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE39905.1 - 0.056 12.4 0.2 0.59 9.0 0.1 2.5 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein NDUF_B12 PF08122.12 EFE39906.1 - 7.5e-26 89.9 2.0 1e-25 89.5 2.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family DUF2828 PF11443.8 EFE39907.1 - 0.0091 14.1 0.0 0.01 14.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) ANAPC_CDC26 PF10471.9 EFE39907.1 - 0.34 11.8 13.9 3.1 8.7 0.6 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Spt20 PF12090.8 EFE39907.1 - 1.4 8.5 18.1 1.3 8.6 9.0 2.1 2 0 0 2 2 2 0 Spt20 family Med3 PF11593.8 EFE39907.1 - 4.2 6.5 14.9 1.6 7.9 6.3 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal CAF1 PF04857.20 EFE39908.1 - 1.9e-17 63.5 0.0 1.5e-11 44.0 0.0 2.0 2 0 0 2 2 2 2 CAF1 family ribonuclease Cu_amine_oxid PF01179.20 EFE39909.1 - 2.2e-128 428.7 0.1 2.8e-128 428.4 0.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EFE39909.1 - 5.9e-18 65.1 0.1 1.2e-17 64.1 0.1 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EFE39909.1 - 1.9e-14 53.6 0.0 3.4e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Asp PF00026.23 EFE39910.1 - 3e-55 187.9 0.1 3.5e-55 187.6 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EFE39910.1 - 0.00082 20.0 0.3 3.1 8.5 0.0 3.1 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 EFE39910.1 - 0.002 17.9 0.0 0.016 15.0 0.0 2.1 1 1 0 2 2 2 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 EFE39910.1 - 0.0022 18.2 0.1 0.31 11.3 0.1 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EFE39910.1 - 0.032 14.8 0.0 3.7 8.2 0.0 2.7 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease TPR_2 PF07719.17 EFE39911.1 - 4.3e-07 29.6 4.9 0.011 15.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFE39911.1 - 1.3e-06 27.9 1.9 0.47 10.4 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFE39911.1 - 7.2e-06 26.2 4.2 0.0081 16.4 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFE39911.1 - 0.00071 19.6 2.5 0.75 10.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFE39911.1 - 0.0075 16.2 2.9 6.3 7.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFE39911.1 - 0.015 15.8 2.1 0.36 11.4 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE39911.1 - 0.041 14.1 0.1 0.16 12.2 0.1 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 SPO22 PF08631.10 EFE39911.1 - 0.055 12.9 0.2 8.8 5.7 0.4 2.3 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like TPR_10 PF13374.6 EFE39911.1 - 1.3 9.0 5.2 17 5.4 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat VASt PF16016.5 EFE39912.1 - 2.2e-34 119.1 0.0 4.3e-34 118.2 0.0 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EFE39912.1 - 3.7e-21 75.1 0.0 7e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 GRAM domain NTP_transf_2 PF01909.23 EFE39913.1 - 1.7e-11 44.3 0.0 3.5e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EFE39913.1 - 2.7e-11 43.5 0.0 5.1e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 EFE39913.1 - 0.019 15.1 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Aldo_ket_red PF00248.21 EFE39914.1 - 5e-66 222.9 0.0 6.2e-66 222.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FA_hydroxylase PF04116.13 EFE39915.1 - 4.8e-25 88.4 25.6 2e-24 86.4 22.6 2.1 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily COX14 PF14880.6 EFE39916.1 - 5.4e-08 32.6 0.5 2.1e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 Cytochrome oxidase c assembly CENP-Q PF13094.6 EFE39916.1 - 0.02 15.1 1.0 0.039 14.2 1.0 1.5 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Methyltransf_23 PF13489.6 EFE39917.1 - 0.002 18.0 0.0 0.003 17.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFE39917.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) HP_OMP_2 PF02521.14 EFE39918.1 - 0.042 12.7 0.0 0.052 12.4 0.0 1.1 1 0 0 1 1 1 0 Putative outer membrane protein DUF4897 PF16238.5 EFE39918.1 - 0.1 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4897) HAD_2 PF13419.6 EFE39919.1 - 1.4e-25 90.5 0.0 1.7e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFE39919.1 - 1.7e-15 57.9 0.0 4.4e-14 53.3 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFE39919.1 - 7.2e-11 42.8 0.0 1.3e-10 42.0 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE39919.1 - 1.1e-07 31.7 0.1 2.7e-07 30.5 0.0 1.8 2 1 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EFE39919.1 - 4.3e-07 30.0 0.0 0.00038 20.5 0.0 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 EFE39919.1 - 0.031 14.1 0.1 5.1 6.9 0.0 2.8 3 0 0 3 3 3 0 Acid Phosphatase Hydrolase_3 PF08282.12 EFE39919.1 - 0.036 13.8 0.0 0.55 9.9 0.0 2.5 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Peptidase_M35 PF02102.15 EFE39920.1 - 2.3e-98 329.4 0.9 2.7e-98 329.2 0.9 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EFE39920.1 - 3.9e-41 141.0 3.2 6.4e-41 140.3 3.2 1.3 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase Glyco_hydro_32N PF00251.20 EFE39920.1 - 0.012 15.2 0.1 0.016 14.8 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain Actin PF00022.19 EFE39921.1 - 2.6e-141 470.9 0.0 2.9e-141 470.8 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFE39921.1 - 0.056 12.3 0.0 11 4.7 0.0 2.9 3 0 0 3 3 3 0 MreB/Mbl protein ATG22 PF11700.8 EFE39922.1 - 1.4e-193 643.9 15.1 5e-188 625.6 7.0 2.0 1 1 1 2 2 2 2 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EFE39922.1 - 0.00011 21.2 56.9 0.00083 18.4 25.6 3.4 2 2 1 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 EFE39922.1 - 0.002 16.8 5.3 0.002 16.8 5.3 2.9 3 0 0 3 3 3 2 MFS/sugar transport protein Hum_adeno_E3A PF05393.11 EFE39922.1 - 0.12 12.3 0.2 0.12 12.3 0.2 2.2 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein Mpp10 PF04006.12 EFE39923.1 - 2.5e-110 369.8 64.3 6.3e-109 365.1 64.3 2.0 1 1 0 1 1 1 1 Mpp10 protein RepA_C PF04796.12 EFE39923.1 - 1.3 9.0 2.9 0.73 9.8 0.1 2.0 2 0 0 2 2 2 0 Plasmid encoded RepA protein Methyltransf_16 PF10294.9 EFE39924.1 - 2.8e-34 118.4 0.0 3.8e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EFE39924.1 - 0.049 13.0 0.2 0.082 12.3 0.1 1.4 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFE39924.1 - 0.066 12.8 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CI-B14_5a PF07347.12 EFE39925.1 - 0.071 13.0 0.2 0.21 11.5 0.0 1.9 2 1 0 2 2 2 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Hox9_act PF04617.13 EFE39926.1 - 0.038 14.7 8.9 0.059 14.1 8.9 1.2 1 0 0 1 1 1 0 Hox9 activation region CDC27 PF09507.10 EFE39926.1 - 0.053 12.9 18.0 0.059 12.8 18.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Hamartin PF04388.12 EFE39926.1 - 0.42 9.2 4.0 0.45 9.1 4.0 1.0 1 0 0 1 1 1 0 Hamartin protein NPR3 PF03666.13 EFE39926.1 - 0.51 9.1 6.2 0.58 8.9 6.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Paf1 PF03985.13 EFE39926.1 - 0.52 9.3 13.0 0.69 8.8 13.0 1.1 1 0 0 1 1 1 0 Paf1 VIR_N PF15912.5 EFE39926.1 - 0.58 9.7 8.9 0.75 9.3 8.9 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal RR_TM4-6 PF06459.12 EFE39926.1 - 0.91 9.3 14.2 1.2 8.9 14.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 EFE39926.1 - 1.2 8.2 3.1 1.4 8.0 3.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Cytomega_UL84 PF06284.11 EFE39926.1 - 1.5 7.1 11.3 2.1 6.7 11.3 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein FAM176 PF14851.6 EFE39926.1 - 1.6 8.4 5.5 2.4 7.8 5.5 1.3 1 0 0 1 1 1 0 FAM176 family SRP-alpha_N PF04086.13 EFE39926.1 - 1.7 8.5 13.4 2 8.2 13.4 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF5580 PF17743.1 EFE39926.1 - 2.3 6.7 8.7 3 6.3 8.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) DDRGK PF09756.9 EFE39926.1 - 3.5 7.2 16.5 4.9 6.7 16.5 1.2 1 0 0 1 1 1 0 DDRGK domain Presenilin PF01080.17 EFE39926.1 - 5.2 5.7 8.2 5.8 5.6 8.2 1.1 1 0 0 1 1 1 0 Presenilin FGF-BP1 PF06473.12 EFE39926.1 - 6.3 6.6 12.2 9 6.0 12.2 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Tim54 PF11711.8 EFE39926.1 - 7.1 5.3 12.9 9 5.0 12.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RPN2_C PF18004.1 EFE39926.1 - 7.7 6.4 18.0 12 5.8 18.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Spore_coat_CotO PF14153.6 EFE39926.1 - 9.1 6.2 17.7 12 5.8 17.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO V-SNARE_C PF12352.8 EFE39927.1 - 0.094 13.0 0.6 0.094 13.0 0.6 2.2 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Sharpin_PH PF16764.5 EFE39927.1 - 0.13 12.1 0.2 0.2 11.4 0.2 1.3 1 0 0 1 1 1 0 Sharpin PH domain Sec1 PF00995.23 EFE39928.1 - 3.2e-114 383.3 0.0 5.7e-114 382.4 0.0 1.4 1 1 0 1 1 1 1 Sec1 family Transposase_22 PF02994.14 EFE39928.1 - 0.0082 16.3 0.1 0.2 11.9 0.0 2.8 3 0 0 3 3 3 1 L1 transposable element RBD-like domain SF3b1 PF08920.10 EFE39929.1 - 2.9e-33 114.9 12.8 5.9e-33 113.9 7.9 3.0 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 EFE39929.1 - 6.2e-11 42.5 8.8 0.21 12.0 0.1 7.9 6 2 3 9 9 9 3 HEAT repeats HEAT_EZ PF13513.6 EFE39929.1 - 7.9e-11 42.2 2.9 0.011 16.3 0.0 6.7 7 1 1 8 8 7 2 HEAT-like repeat HEAT PF02985.22 EFE39929.1 - 1.6e-08 34.1 9.3 0.69 10.3 0.2 8.9 9 0 0 9 9 8 1 HEAT repeat Cnd1 PF12717.7 EFE39929.1 - 1.6e-05 25.0 1.3 4.8 7.2 0.0 6.2 5 2 2 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFE39929.1 - 4e-05 24.1 0.2 2.3 8.9 0.0 5.4 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 EFE39929.1 - 0.00016 21.6 0.8 0.06 13.3 0.0 4.8 6 1 0 6 6 6 1 Domain of unknown function (DUF3385) NUC173 PF08161.12 EFE39929.1 - 0.0002 21.1 0.2 1.2 8.8 0.0 4.1 5 1 0 5 5 5 2 NUC173 domain UNC45-central PF11701.8 EFE39929.1 - 0.00094 19.2 0.0 0.0035 17.3 0.0 1.9 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central UME PF08064.13 EFE39929.1 - 0.0048 16.8 0.6 8.3 6.4 0.0 4.8 7 0 0 7 7 7 1 UME (NUC010) domain CLASP_N PF12348.8 EFE39929.1 - 0.005 16.4 0.1 0.93 9.0 0.0 3.3 3 0 0 3 3 3 1 CLASP N terminal TAF6_C PF07571.13 EFE39929.1 - 0.021 15.1 0.0 1.1 9.7 0.0 3.5 3 1 0 3 3 2 0 TAF6 C-terminal HEAT repeat domain DRIM PF07539.12 EFE39929.1 - 0.081 11.2 0.2 8.4 4.6 0.0 3.6 2 1 2 4 4 4 0 Down-regulated in metastasis CRM1_C PF08767.11 EFE39929.1 - 0.16 11.1 0.2 0.61 9.2 0.0 2.1 2 0 0 2 2 2 0 CRM1 C terminal Ecm29 PF13001.7 EFE39929.1 - 0.17 10.5 0.0 1.6 7.3 0.0 2.3 2 1 1 3 3 3 0 Proteasome stabiliser CDC45 PF02724.14 EFE39929.1 - 9.7 4.3 8.9 10 4.2 7.5 1.7 2 0 0 2 2 2 0 CDC45-like protein DUF3455 PF11937.8 EFE39930.1 - 2.9e-18 66.8 0.0 3.8e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Methyltransf_11 PF08241.12 EFE39931.1 - 0.00069 20.2 0.0 0.0014 19.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE39931.1 - 0.029 15.1 0.0 0.062 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EFE39931.1 - 0.091 11.9 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family p450 PF00067.22 EFE39933.1 - 0.051 12.3 0.1 0.072 11.8 0.1 1.2 1 0 0 1 1 1 0 Cytochrome P450 LZ_Tnp_IS66 PF13007.7 EFE39934.1 - 0.058 14.2 1.2 0.32 11.8 0.0 2.1 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain TPR_1 PF00515.28 EFE39937.1 - 1.1e-40 135.8 6.8 1.2e-06 28.1 0.0 8.5 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 EFE39937.1 - 9.5e-35 115.9 13.2 0.00057 19.8 0.0 9.3 9 0 0 9 9 9 7 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE39937.1 - 2.4e-31 107.8 15.9 6.1e-24 84.1 0.5 4.6 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EFE39937.1 - 3.1e-26 90.8 6.1 1.2e-07 31.3 1.0 8.6 8 1 1 9 9 9 6 TPR repeat TPR_8 PF13181.6 EFE39937.1 - 1.1e-25 87.7 9.5 0.00098 19.2 0.5 9.3 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFE39937.1 - 9.2e-23 80.5 15.3 4.6e-08 33.5 0.4 7.3 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFE39937.1 - 6e-21 73.3 6.7 0.0021 18.7 0.1 9.3 7 1 2 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFE39937.1 - 2.3e-19 69.7 10.4 7.8e-09 36.1 0.2 8.2 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE39937.1 - 2.8e-15 56.4 17.7 0.0042 17.3 0.1 7.9 6 2 1 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFE39937.1 - 5e-13 48.4 11.6 0.0085 16.4 0.0 9.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFE39937.1 - 4.6e-09 35.7 5.6 0.047 13.7 0.0 7.3 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFE39937.1 - 3.7e-07 30.4 9.2 2.2 9.1 0.1 7.8 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFE39937.1 - 3.7e-06 27.0 0.8 0.05 13.8 0.1 4.4 2 1 3 5 5 5 1 Tetratricopeptide repeat ChAPs PF09295.10 EFE39937.1 - 0.0066 15.5 0.0 0.49 9.3 0.0 2.5 1 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_MalT PF17874.1 EFE39937.1 - 0.038 13.4 1.8 1.7 7.9 0.0 3.5 3 1 1 4 4 4 0 MalT-like TPR region PPTA PF01239.22 EFE39937.1 - 0.051 13.3 0.2 0.15 11.9 0.2 1.9 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat TPR_21 PF09976.9 EFE39937.1 - 0.42 10.3 6.3 1.1 8.9 0.5 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 EFE39937.1 - 0.52 10.3 6.0 16 5.5 0.0 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat Macoilin PF09726.9 EFE39937.1 - 1.5 7.3 8.6 2.8 6.4 8.6 1.4 1 0 0 1 1 1 0 Macoilin family Acyltransferase PF01553.21 EFE39938.1 - 3e-30 104.6 0.0 4.8e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase ACPS PF01648.20 EFE39939.1 - 1.5e-13 50.9 0.0 5.6e-13 49.0 0.0 1.9 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily SNO PF01174.19 EFE39940.1 - 3e-51 174.0 0.0 1.7e-40 138.9 0.0 2.1 1 1 1 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EFE39940.1 - 1.4e-08 34.6 0.0 3.6e-07 30.0 0.0 2.5 3 0 0 3 3 3 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 EFE39940.1 - 0.0027 17.5 0.0 0.019 14.8 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.24 EFE39940.1 - 0.04 13.7 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Peptidase_S51 PF03575.17 EFE39940.1 - 0.044 13.4 0.0 0.068 12.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S51 Nup54 PF13874.6 EFE39941.1 - 0.016 15.4 0.9 0.016 15.4 0.9 2.3 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 Rotamase PF00639.21 EFE39943.1 - 1.1e-19 71.1 0.1 2.1e-19 70.3 0.1 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EFE39943.1 - 1.4e-11 45.0 0.0 2.4e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EFE39943.1 - 4.5e-09 36.2 0.4 4.5e-09 36.2 0.4 1.7 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 EFE39943.1 - 8.8e-05 23.3 0.0 0.00013 22.8 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW_1 PF18507.1 EFE39943.1 - 0.037 13.7 0.1 0.059 13.1 0.1 1.3 1 0 0 1 1 1 0 WW domain Calcipressin PF04847.12 EFE39945.1 - 1.8e-33 115.9 0.6 6.4e-33 114.1 0.6 1.8 1 1 0 1 1 1 1 Calcipressin Pex14_N PF04695.13 EFE39946.1 - 1.2e-42 146.3 3.0 1.2e-42 146.3 3.0 2.4 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PAPA-1 PF04795.12 EFE39948.1 - 9.7e-28 96.8 5.9 9.7e-28 96.8 5.9 3.3 3 0 0 3 3 3 1 PAPA-1-like conserved region NOA36 PF06524.12 EFE39948.1 - 3.3 7.0 25.1 4.1 6.7 8.9 2.5 2 0 0 2 2 2 0 NOA36 protein Mus7 PF09462.10 EFE39949.1 - 2.4e-158 528.8 0.0 3.4e-158 528.3 0.0 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family DUF4050 PF13259.6 EFE39950.1 - 2.1e-56 191.1 1.2 2.1e-56 191.1 1.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) TPR_19 PF14559.6 EFE39951.1 - 0.00048 20.6 6.4 0.42 11.1 3.3 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFE39951.1 - 0.02 15.0 3.6 25 5.3 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 EFE39951.1 - 0.067 12.9 0.2 0.14 11.8 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 EFE39951.1 - 0.16 12.3 0.6 5 7.6 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFE39951.1 - 0.18 11.7 0.9 32 4.5 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFE39951.1 - 0.6 10.8 4.3 0.6 10.8 0.9 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.25 EFE39952.1 - 7e-18 64.9 0.0 9.5e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39952.1 - 8.7e-10 38.3 0.0 6.2e-09 35.5 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 EFE39952.1 - 0.015 14.9 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EFE39952.1 - 0.033 14.1 0.0 0.048 13.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EFE39952.1 - 0.043 12.8 0.0 0.067 12.1 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 EFE39952.1 - 0.054 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 EFE39952.1 - 0.093 11.5 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase AAA PF00004.29 EFE39953.1 - 6.1e-39 133.5 0.0 9.4e-38 129.6 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE39953.1 - 2.8e-09 36.6 0.1 7.7e-09 35.2 0.0 1.9 2 0 0 2 2 1 1 AAA+ lid domain AAA_16 PF13191.6 EFE39953.1 - 4.1e-05 24.0 0.1 0.0018 18.7 0.0 3.1 2 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EFE39953.1 - 0.00012 21.8 0.0 0.00028 20.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFE39953.1 - 0.00016 21.9 0.1 0.015 15.6 0.0 2.7 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EFE39953.1 - 0.00035 19.9 0.0 0.00081 18.7 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EFE39953.1 - 0.00056 20.1 0.0 0.0031 17.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFE39953.1 - 0.00064 19.7 0.0 0.0027 17.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFE39953.1 - 0.0037 16.7 0.1 0.0088 15.4 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EFE39953.1 - 0.01 15.6 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 EFE39953.1 - 0.011 15.7 0.0 0.029 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFE39953.1 - 0.012 16.1 0.0 0.081 13.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFE39953.1 - 0.02 15.3 0.0 0.057 13.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EFE39953.1 - 0.027 14.2 0.0 0.062 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EFE39953.1 - 0.052 13.0 0.0 0.27 10.6 0.0 2.1 3 0 0 3 3 3 0 Bacterial TniB protein TsaE PF02367.17 EFE39953.1 - 0.066 13.2 0.1 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFE39953.1 - 0.07 13.4 0.0 0.07 13.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_2 PF07724.14 EFE39953.1 - 0.092 12.9 0.0 0.83 9.8 0.0 2.6 2 1 0 2 2 1 0 AAA domain (Cdc48 subfamily) NACHT PF05729.12 EFE39953.1 - 0.12 12.3 0.1 0.38 10.7 0.1 1.8 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 EFE39953.1 - 0.13 12.0 0.2 2 8.1 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 EFE39953.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase AAA_17 PF13207.6 EFE39953.1 - 0.22 12.0 0.1 0.22 12.0 0.1 2.1 2 0 0 2 2 1 0 AAA domain NGP1NT PF08153.12 EFE39955.1 - 3.1e-50 169.7 0.1 4.5e-50 169.1 0.1 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EFE39956.1 - 3.4e-14 52.9 0.0 5.6e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFE39956.1 - 1.6e-05 24.5 0.0 2.2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFE39956.1 - 0.014 15.5 0.4 0.38 10.8 0.0 2.6 2 1 1 3 3 3 0 Dynamin family RsgA_GTPase PF03193.16 EFE39956.1 - 0.061 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Arf PF00025.21 EFE39956.1 - 0.086 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family IIGP PF05049.13 EFE39956.1 - 0.2 10.7 0.1 0.29 10.1 0.1 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Nop14 PF04147.12 EFE39956.1 - 3.3 5.8 5.5 4.3 5.4 5.5 1.1 1 0 0 1 1 1 0 Nop14-like family Gpr1_Fun34_YaaH PF01184.19 EFE39957.1 - 3.5e-48 163.9 13.2 5.5e-48 163.3 13.2 1.3 1 1 0 1 1 1 1 GPR1/FUN34/yaaH family YrhC PF14143.6 EFE39957.1 - 0.023 14.8 4.5 0.059 13.5 4.5 1.7 1 0 0 1 1 1 0 YrhC-like protein p450 PF00067.22 EFE39958.1 - 7.2e-65 219.5 0.0 7.9e-65 219.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TFIIE_alpha PF02002.17 EFE39958.1 - 0.2 11.6 0.0 0.41 10.5 0.0 1.5 1 0 0 1 1 1 0 TFIIE alpha subunit Pkinase PF00069.25 EFE39959.1 - 1.2e-38 133.0 0.0 5.1e-38 130.9 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE39959.1 - 2.4e-28 99.1 0.0 3.4e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE39959.1 - 0.0065 15.3 0.0 0.0095 14.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFE39959.1 - 0.055 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Prefoldin_3 PF13758.6 EFE39960.1 - 9.2e-35 118.7 0.1 2.8e-34 117.1 0.1 1.9 1 0 0 1 1 1 1 Prefoldin subunit DUF3835 PF12927.7 EFE39960.1 - 1.1e-25 90.3 9.2 7.6e-24 84.4 0.5 4.1 3 0 0 3 3 3 2 Domain of unknown function (DUF3835) Prefoldin PF02996.17 EFE39960.1 - 0.013 15.4 0.1 0.04 13.8 0.1 1.9 1 1 0 1 1 1 0 Prefoldin subunit Lzipper-MIP1 PF14389.6 EFE39960.1 - 0.02 15.2 3.9 2.5 8.5 0.1 3.8 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Prefoldin_2 PF01920.20 EFE39960.1 - 0.068 13.1 2.9 2.3 8.2 0.0 3.3 3 0 0 3 3 3 0 Prefoldin subunit MerR-DNA-bind PF09278.11 EFE39960.1 - 0.12 12.9 0.2 30 5.3 0.0 3.1 2 0 0 2 2 2 0 MerR, DNA binding PepSY_2 PF13670.6 EFE39960.1 - 0.15 12.1 0.0 0.88 9.6 0.1 2.3 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Zip PF02535.22 EFE39961.1 - 2.4e-40 138.8 25.5 2.4e-40 138.8 25.5 2.0 2 1 0 2 2 2 1 ZIP Zinc transporter Amino_oxidase PF01593.24 EFE39962.1 - 5.5e-12 45.7 0.0 4.6e-10 39.4 0.0 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase RFC1 PF08519.12 EFE39963.1 - 1.5e-58 197.5 0.2 9.5e-58 194.8 0.1 2.2 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EFE39963.1 - 1.9e-13 50.6 0.0 6.7e-13 48.8 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EFE39963.1 - 3.7e-09 37.1 1.1 5.8e-09 36.5 0.1 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFE39963.1 - 0.00018 21.8 0.0 0.00048 20.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EFE39963.1 - 0.0002 21.4 0.0 0.00044 20.2 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EFE39963.1 - 0.0023 18.3 0.1 0.012 16.0 0.1 2.1 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFE39963.1 - 0.0029 17.4 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 EFE39963.1 - 0.0052 16.5 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFE39963.1 - 0.0077 16.4 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFE39963.1 - 0.014 15.5 0.0 0.033 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFE39963.1 - 0.014 15.9 0.0 0.048 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFE39963.1 - 0.059 13.4 0.1 0.37 10.8 0.0 2.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EFE39963.1 - 0.067 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 EFE39963.1 - 0.097 12.6 0.0 0.29 11.0 0.0 1.8 2 0 0 2 2 2 0 NACHT domain DNA_pol3_delta2 PF13177.6 EFE39964.1 - 2.5e-10 40.4 0.2 5.1e-10 39.4 0.2 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EFE39964.1 - 5.3e-07 30.1 0.1 1.1e-06 29.1 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFE39964.1 - 2.8e-06 27.7 0.1 1e-05 25.8 0.1 1.9 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EFE39964.1 - 0.00086 19.1 0.4 0.0022 17.8 0.4 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFE39964.1 - 0.0026 18.2 0.4 0.013 15.9 0.2 2.2 2 1 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 EFE39964.1 - 0.015 15.8 0.2 0.033 14.7 0.2 1.8 1 1 0 1 1 1 0 ABC transporter Rad17 PF03215.15 EFE39964.1 - 0.05 13.5 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain TK PF00265.18 EFE39964.1 - 0.12 12.2 0.8 0.68 9.8 0.8 2.0 1 1 0 1 1 1 0 Thymidine kinase MBF1 PF08523.10 EFE39966.1 - 1.1e-26 93.1 0.4 1.1e-26 93.1 0.4 1.7 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EFE39966.1 - 8.2e-12 45.0 0.1 1.9e-11 43.8 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EFE39966.1 - 2.1e-07 31.2 0.3 7.1e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain Iso_dh PF00180.20 EFE39967.1 - 1.4e-49 169.2 0.0 6.3e-49 167.0 0.0 1.8 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase RNA_polI_A34 PF08208.11 EFE39968.1 - 4.8 7.2 21.3 5.2 7.1 21.3 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DNA_pol_A_exo1 PF01612.20 EFE39969.1 - 7.8e-41 139.7 0.5 1.3e-40 139.0 0.5 1.4 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 EFE39969.1 - 4.5e-30 104.2 5.7 1.8e-28 99.1 5.5 3.1 2 1 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 EFE39969.1 - 1.3e-11 44.4 0.6 3e-11 43.1 0.1 2.0 2 0 0 2 2 2 1 HRDC domain Gpi1 PF05024.15 EFE39970.1 - 4.2e-26 92.2 0.8 8.7e-26 91.2 0.8 1.5 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Mucin PF01456.17 EFE39970.1 - 1.4 8.9 13.8 6.1 6.8 13.8 2.0 1 1 0 1 1 1 0 Mucin-like glycoprotein MutS_V PF00488.21 EFE39971.1 - 4.2e-82 274.7 0.1 7.6e-82 273.9 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFE39971.1 - 1.5e-37 129.7 0.6 4.8e-37 128.0 0.3 2.0 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EFE39971.1 - 6.7e-23 81.5 0.1 2.8e-22 79.5 0.0 2.1 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EFE39971.1 - 1.4e-19 70.2 0.4 5.1e-19 68.4 0.4 2.1 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 EFE39971.1 - 8.5e-16 58.2 0.0 8.7e-15 54.9 0.0 2.4 2 0 0 2 2 2 1 MutS domain I Tnp_22_trimer PF17489.2 EFE39973.1 - 0.26 11.3 3.3 2.7 8.0 0.6 2.4 2 0 0 2 2 2 0 L1 transposable element trimerization domain zf-C2H2 PF00096.26 EFE39974.1 - 4.1e-05 23.8 11.7 0.017 15.6 1.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE39974.1 - 9.9e-05 22.6 5.8 0.00031 21.0 3.8 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE39974.1 - 0.00071 20.2 11.1 0.083 13.8 2.9 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger Kinesin PF00225.23 EFE39974.1 - 0.015 14.2 0.0 0.036 13.0 0.0 1.5 1 0 0 1 1 1 0 Kinesin motor domain DUF3807 PF12720.7 EFE39975.1 - 0.15 12.3 12.6 0.2 11.9 12.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CDC45 PF02724.14 EFE39975.1 - 0.38 9.0 13.2 0.45 8.8 13.2 1.0 1 0 0 1 1 1 0 CDC45-like protein YqfQ PF14181.6 EFE39975.1 - 0.74 10.0 8.9 1.2 9.3 8.9 1.3 1 0 0 1 1 1 0 YqfQ-like protein Rrn6 PF10214.9 EFE39975.1 - 0.97 7.8 9.2 1.2 7.6 9.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Dsh_C PF12316.8 EFE39975.1 - 1.2 9.5 7.5 1.4 9.3 7.5 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal UPF0239 PF06783.11 EFE39975.1 - 1.3 9.3 10.8 2.6 8.3 10.8 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) DUF1764 PF08576.10 EFE39975.1 - 1.5 9.8 13.4 2.3 9.2 13.4 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Sec62 PF03839.16 EFE39975.1 - 2 7.8 6.0 2.4 7.6 6.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 RR_TM4-6 PF06459.12 EFE39975.1 - 2.7 7.7 9.5 3.3 7.5 9.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 EFE39975.1 - 3.9 6.1 7.3 3.9 6.1 7.3 1.1 1 0 0 1 1 1 0 Presenilin DUF1840 PF08895.11 EFE39975.1 - 6.6 7.1 8.5 15 6.0 8.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) NPR3 PF03666.13 EFE39975.1 - 6.7 5.4 11.4 7.1 5.3 11.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 EFE39975.1 - 9 6.3 5.8 11 5.9 5.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region COG5 PF10392.9 EFE39976.1 - 2.3e-37 128.1 1.9 4e-37 127.3 0.0 2.4 3 0 0 3 3 3 1 Golgi transport complex subunit 5 SYS1 PF09801.9 EFE39977.1 - 3.6e-54 182.8 7.8 4.2e-54 182.6 7.8 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DUF485 PF04341.12 EFE39977.1 - 1.3 9.1 7.7 0.076 13.0 2.2 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF485 COX6B PF02297.17 EFE39978.1 - 1.8e-23 82.5 4.0 2.3e-23 82.2 4.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Swi6_N PF18530.1 EFE39978.1 - 0.055 13.6 0.0 0.12 12.6 0.0 1.4 2 0 0 2 2 2 0 Swi6 N-terminal domain CHCH PF06747.13 EFE39978.1 - 0.14 12.3 2.1 2 8.6 0.7 2.5 2 1 0 2 2 2 0 CHCH domain Pyr_redox_2 PF07992.14 EFE39979.1 - 1.9e-53 181.6 0.4 2.4e-53 181.3 0.4 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE39979.1 - 3.6e-17 62.7 0.6 9.2e-15 55.0 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE39979.1 - 1.4e-07 31.1 0.0 0.0029 16.9 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 EFE39979.1 - 1.5e-06 28.7 0.0 3.7e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Reductase C-terminal K_oxygenase PF13434.6 EFE39979.1 - 1.1e-05 24.7 0.0 0.14 11.3 0.0 2.5 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFE39979.1 - 2.8e-05 24.2 0.1 0.56 10.2 0.0 3.0 3 0 0 3 3 3 2 FAD-NAD(P)-binding DUF1188 PF06690.11 EFE39979.1 - 0.0011 18.6 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) NAD_binding_7 PF13241.6 EFE39979.1 - 0.0046 17.4 0.3 0.71 10.3 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding FIST PF08495.10 EFE39979.1 - 0.0091 16.0 0.1 0.037 14.0 0.0 2.0 2 0 0 2 2 2 1 FIST N domain HI0933_like PF03486.14 EFE39979.1 - 0.0099 14.6 0.4 1.9 7.1 0.0 2.7 3 0 0 3 3 3 2 HI0933-like protein Amino_oxidase PF01593.24 EFE39979.1 - 0.026 13.8 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase TrkA_N PF02254.18 EFE39979.1 - 0.042 14.1 0.3 5.5 7.3 0.2 2.8 3 0 0 3 3 3 0 TrkA-N domain IDEAL PF08858.10 EFE39980.1 - 0.48 10.2 2.6 1.1 9.0 2.6 1.6 1 0 0 1 1 1 0 IDEAL domain Bul1_C PF04426.12 EFE39981.1 - 0.017 14.6 0.3 0.049 13.0 0.0 1.9 3 0 0 3 3 3 0 Bul1 C terminus Arrestin_N PF00339.29 EFE39981.1 - 0.034 14.2 0.1 1.6 8.8 0.0 2.8 3 0 0 3 3 3 0 Arrestin (or S-antigen), N-terminal domain SOG2 PF10428.9 EFE39982.1 - 9 5.4 9.3 9.3 5.3 9.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein PDEase_I PF00233.19 EFE39983.1 - 0.0023 17.7 0.1 0.0036 17.1 0.1 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HflK_N PF12221.8 EFE39983.1 - 0.0045 17.0 0.0 0.0079 16.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial membrane protein N terminal HD PF01966.22 EFE39983.1 - 0.016 15.4 1.4 0.17 12.1 0.5 2.7 2 1 0 2 2 2 0 HD domain RMI1_C PF16099.5 EFE39983.1 - 0.074 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold MA3 PF02847.17 EFE39985.1 - 1e-26 93.1 0.2 2.9e-26 91.7 0.1 1.9 2 0 0 2 2 2 1 MA3 domain DNA_pol_phi PF04931.13 EFE39985.1 - 1.4 7.0 10.2 2.5 6.1 10.2 1.3 1 0 0 1 1 1 0 DNA polymerase phi HECT PF00632.25 EFE39986.1 - 2.8e-82 276.6 0.0 4.9e-82 275.9 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 EFE39986.1 - 0.011 15.4 0.2 0.042 13.6 0.2 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif FSAP_sig_propep PF03032.15 EFE39986.1 - 0.32 11.0 1.0 1.3 9.1 1.0 2.1 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide Utp14 PF04615.13 EFE39988.1 - 1.9e-212 707.9 65.7 1.9e-212 707.9 65.7 2.4 1 1 1 2 2 2 1 Utp14 protein TFIIF_alpha PF05793.12 EFE39989.1 - 0.071 11.7 0.5 0.078 11.6 0.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Cnd2 PF05786.14 EFE39989.1 - 0.08 11.6 0.5 0.083 11.5 0.5 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 Cwf_Cwc_15 PF04889.12 EFE39989.1 - 1.6 8.4 5.8 2 8.1 5.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 EFE39989.1 - 5.2 6.1 7.9 6.2 5.9 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Glyco_hydro81C PF17652.1 EFE39990.1 - 1.7e-163 543.9 2.9 2.1e-163 543.6 2.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EFE39990.1 - 2e-119 398.5 0.3 2.9e-119 398.0 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Peptidase_M28 PF04389.17 EFE39991.1 - 7.2e-34 117.2 0.5 1.3e-33 116.4 0.4 1.4 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 EFE39991.1 - 9.8e-05 22.1 0.1 0.00028 20.6 0.0 1.9 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 DUF4317 PF14199.6 EFE39991.1 - 0.067 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) SHR3_chaperone PF08229.11 EFE39995.1 - 5.1e-82 273.4 0.0 6.7e-82 273.0 0.0 1.1 1 0 0 1 1 1 1 ER membrane protein SH3 Phage_holin_2_4 PF16082.5 EFE39995.1 - 0.12 12.1 3.4 0.15 11.8 1.6 2.0 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like T_Ag_DNA_bind PF02217.16 EFE39996.1 - 0.0072 16.9 0.6 0.016 15.8 0.6 1.6 1 1 0 1 1 1 1 Origin of replication binding protein RVT_3 PF13456.6 EFE39996.1 - 0.095 12.5 0.0 4.1 7.2 0.0 2.4 2 0 0 2 2 2 0 Reverse transcriptase-like Arrestin_N PF00339.29 EFE39997.1 - 3.1e-15 56.5 0.0 5e-14 52.6 0.0 2.7 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EFE39997.1 - 6.1e-05 23.5 0.0 0.027 14.9 0.0 3.2 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain MFS_1 PF07690.16 EFE39998.1 - 6.4e-19 68.1 53.6 1.1e-17 64.0 50.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3379 PF11859.8 EFE39998.1 - 0.26 10.6 0.0 0.58 9.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3379) CbtB PF09489.10 EFE39998.1 - 4.8 7.4 0.0 4.8 7.4 0.0 4.7 5 0 0 5 5 5 0 Probable cobalt transporter subunit (CbtB) SelP_N PF04592.14 EFE39999.1 - 0.26 10.7 16.3 0.34 10.3 16.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 EFE39999.1 - 1.3 7.7 2.9 1.4 7.6 2.9 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 EFE39999.1 - 4.5 5.7 13.3 5.4 5.4 13.3 1.1 1 0 0 1 1 1 0 Macoilin family FAM76 PF16046.5 EFE39999.1 - 6.1 6.1 5.4 7.7 5.8 5.4 1.1 1 0 0 1 1 1 0 FAM76 protein Lin-8 PF03353.15 EFE39999.1 - 6.1 6.3 8.3 8.1 5.9 8.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist APG5 PF04106.12 EFE40000.1 - 2.8e-50 171.0 0.0 1e-32 113.6 0.0 2.1 1 1 1 2 2 2 2 Autophagy protein Apg5 QCR10 PF09796.9 EFE40001.1 - 4.7e-22 77.8 0.0 7.7e-22 77.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) zf-H2C2_2 PF13465.6 EFE40002.1 - 7.3e-06 26.2 12.5 1.5e-05 25.2 1.4 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-Di19 PF05605.12 EFE40002.1 - 0.00013 22.2 4.6 0.00027 21.2 4.6 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EFE40002.1 - 0.00018 22.1 15.0 0.017 15.9 5.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFE40002.1 - 0.0014 18.8 4.8 0.076 13.3 1.2 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EFE40002.1 - 0.026 15.0 14.5 0.11 13.0 7.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-met PF12874.7 EFE40002.1 - 0.7 10.4 5.0 4.1 7.9 0.8 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Myb_DNA-binding PF00249.31 EFE40004.1 - 4.9e-13 49.0 1.9 4.7e-09 36.3 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFE40004.1 - 5.9e-07 29.6 4.3 0.00073 19.7 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Methyltransf_11 PF08241.12 EFE40006.1 - 1.8e-12 47.7 0.0 2.9e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE40006.1 - 5.9e-10 39.7 0.0 1.1e-09 38.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE40006.1 - 1.6e-07 31.3 0.0 6.9e-07 29.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE40006.1 - 2.5e-06 27.4 0.0 3.6e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE40006.1 - 5e-05 24.0 0.0 9.5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EFE40006.1 - 0.095 12.3 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CAP_GLY PF01302.25 EFE40007.1 - 8e-21 73.8 0.1 1.4e-20 73.1 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EFE40007.1 - 5.9e-13 49.1 0.0 1.1e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 EFE40007.1 - 2.1e-06 27.4 0.0 9.1e-06 25.3 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin family CENP-C_C PF11699.8 EFE40008.1 - 7.8e-28 96.5 1.1 7.8e-28 96.5 1.1 1.9 2 0 0 2 2 2 1 Mif2/CENP-C like Mif2_N PF15624.6 EFE40008.1 - 1e-14 55.4 3.1 1e-14 55.4 3.1 4.4 2 1 3 5 5 5 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 EFE40008.1 - 0.071 12.8 0.0 0.2 11.4 0.0 1.8 1 0 0 1 1 1 0 Cupin domain RNase_HII PF01351.18 EFE40009.1 - 1.3e-44 152.4 0.0 3.7e-41 141.1 0.0 2.1 1 1 1 2 2 2 2 Ribonuclease HII Pex16 PF08610.10 EFE40010.1 - 2.9e-122 407.9 0.4 2.3e-114 382.0 0.1 2.5 1 1 1 2 2 2 2 Peroxisomal membrane protein (Pex16) SAE2 PF08573.10 EFE40011.1 - 8.6e-28 97.7 1.7 1.8e-25 90.2 0.0 3.2 2 0 0 2 2 2 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Nsp1_C PF05064.13 EFE40011.1 - 0.017 15.0 1.8 0.041 13.7 1.8 1.7 1 0 0 1 1 1 0 Nsp1-like C-terminal region EzrA PF06160.12 EFE40011.1 - 0.028 12.6 8.8 0.038 12.2 8.8 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Cnn_1N PF07989.11 EFE40011.1 - 0.032 14.4 7.8 1.4 9.2 6.4 3.2 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 KASH_CCD PF14662.6 EFE40011.1 - 0.033 14.0 8.2 0.081 12.7 8.2 1.6 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 EFE40011.1 - 0.058 13.9 15.0 0.12 12.9 15.0 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region TMPIT PF07851.13 EFE40011.1 - 0.076 12.2 7.1 0.11 11.7 7.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein HOOK PF05622.12 EFE40011.1 - 0.14 10.3 11.0 0.21 9.7 11.0 1.1 1 0 0 1 1 1 0 HOOK protein DUF724 PF05266.14 EFE40011.1 - 0.23 11.3 8.4 0.41 10.4 8.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF2524 PF10732.9 EFE40011.1 - 0.27 11.6 5.7 0.6 10.5 5.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) Rotamase_2 PF13145.6 EFE40011.1 - 0.41 11.5 2.5 0.91 10.4 2.5 1.6 1 0 0 1 1 1 0 PPIC-type PPIASE domain DUF745 PF05335.13 EFE40011.1 - 1 9.1 6.9 1.8 8.3 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DivIC PF04977.15 EFE40011.1 - 1.8 8.4 7.0 0.81 9.5 3.5 2.0 1 1 1 2 2 2 0 Septum formation initiator YabA PF06156.13 EFE40011.1 - 3 8.5 6.7 2.4 8.8 3.5 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Exonuc_VII_L PF02601.15 EFE40011.1 - 7.8 6.0 6.5 14 5.1 6.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit WD40 PF00400.32 EFE40012.1 - 0.055 14.4 2.2 15 6.6 0.2 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat CNH PF00780.22 EFE40012.1 - 0.17 11.4 0.0 0.91 9.1 0.0 1.9 2 0 0 2 2 2 0 CNH domain TMEM214 PF10151.9 EFE40013.1 - 3.1 6.2 3.6 3.9 5.8 3.6 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator SR-25 PF10500.9 EFE40013.1 - 4.8 6.7 12.7 4.3 6.9 7.0 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Cupin_8 PF13621.6 EFE40014.1 - 1.9e-15 57.3 0.0 3.2e-12 46.7 0.0 2.1 1 1 1 2 2 2 2 Cupin-like domain JmjC PF02373.22 EFE40014.1 - 2.9e-09 37.4 0.2 9.4e-08 32.5 0.1 2.7 2 1 0 2 2 2 1 JmjC domain, hydroxylase F-box-like PF12937.7 EFE40014.1 - 9.1e-07 28.7 0.0 2.1e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE40014.1 - 0.00054 19.8 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 EFE40014.1 - 0.16 12.5 0.0 0.33 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Glyco_hydro_38N PF01074.22 EFE40015.1 - 7.8e-87 291.3 0.6 7.8e-87 291.3 0.6 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EFE40015.1 - 5.9e-55 186.6 0.2 5.3e-54 183.5 0.1 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFE40015.1 - 1.1e-25 89.6 0.0 2.2e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EFE40015.1 - 6.2e-09 35.8 0.0 1.6e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain 7TMR-DISMED2 PF07696.11 EFE40015.1 - 0.0087 16.1 0.1 0.062 13.4 0.0 2.3 2 0 0 2 2 2 1 7TMR-DISM extracellular 2 Glyco_hydro_57 PF03065.15 EFE40015.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 NUDIX PF00293.28 EFE40017.1 - 6.7e-09 35.9 0.0 1.4e-08 34.8 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain TRM13 PF05206.14 EFE40017.1 - 0.1 12.1 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase TRM13 PHINT_rpt PF14882.6 EFE40017.1 - 0.16 12.3 1.5 0.44 10.9 1.5 1.7 1 0 0 1 1 1 0 Phage-integrase repeat unit LETM1 PF07766.13 EFE40018.1 - 3.2e-103 344.8 0.1 5.9e-103 343.9 0.1 1.4 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.27 EFE40018.1 - 0.0081 15.9 0.0 0.55 10.1 0.0 3.1 3 0 0 3 3 3 1 SAP domain DUF2838 PF10998.8 EFE40019.1 - 2.1e-39 134.2 11.0 2.1e-39 134.2 11.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) Exonuc_VII_L PF02601.15 EFE40019.1 - 0.057 13.0 0.4 0.086 12.4 0.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tropomyosin_1 PF12718.7 EFE40019.1 - 0.066 13.4 2.5 0.13 12.4 2.5 1.4 1 0 0 1 1 1 0 Tropomyosin like ApoLp-III PF07464.11 EFE40019.1 - 0.19 11.8 2.8 0.34 11.0 2.8 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) OmpH PF03938.14 EFE40019.1 - 2.8 8.3 8.1 1.5 9.2 5.6 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Complex1_30kDa PF00329.19 EFE40022.1 - 3.3e-46 156.9 0.0 4.6e-46 156.4 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit PLU-1 PF08429.11 EFE40023.1 - 5.5e-110 367.7 15.5 1e-107 360.3 14.0 2.3 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.22 EFE40023.1 - 2.1e-42 144.1 1.0 6.7e-42 142.5 0.4 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase ARID PF01388.21 EFE40023.1 - 8.6e-22 77.6 0.1 2.6e-21 76.1 0.1 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 EFE40023.1 - 1.6e-18 66.4 3.2 3.8e-18 65.1 3.2 1.7 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 EFE40023.1 - 1.6e-17 63.1 27.7 1.1e-09 38.1 6.9 3.5 3 0 0 3 3 3 2 PHD-finger zf-C5HC2 PF02928.16 EFE40023.1 - 3e-12 46.7 5.2 8.9e-12 45.2 5.2 1.9 1 0 0 1 1 1 1 C5HC2 zinc finger zf-PHD-like PF15446.6 EFE40023.1 - 0.29 10.7 14.7 0.098 12.3 1.7 3.2 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 EFE40023.1 - 3.5 7.6 24.9 0.24 11.3 4.4 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 EFE40023.1 - 3.7 7.2 13.5 0.033 13.8 1.5 2.7 2 0 0 2 2 2 0 PHD-finger PHD_4 PF16866.5 EFE40023.1 - 4.2 7.5 20.7 0.23 11.6 4.6 3.0 2 0 0 2 2 2 0 PHD-finger FANCL_C PF11793.8 EFE40024.1 - 1.3e-05 25.3 4.6 2e-05 24.6 4.6 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain zf-HC5HC2H PF13771.6 EFE40024.1 - 0.021 15.1 2.1 0.035 14.4 2.1 1.3 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EFE40024.1 - 0.026 14.7 0.9 0.042 14.0 0.9 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain Prok-RING_1 PF14446.6 EFE40024.1 - 0.36 10.8 5.5 0.15 12.0 2.1 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Thymidylate_kin PF02223.17 EFE40025.1 - 3.5e-26 92.0 0.0 3.9e-26 91.9 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 EFE40025.1 - 0.02 15.1 0.0 0.024 14.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain TGT PF01702.18 EFE40026.1 - 5.4e-54 183.7 0.0 6.5e-54 183.4 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase MFS_1 PF07690.16 EFE40027.1 - 2.7e-15 56.2 7.5 2.7e-15 56.2 7.5 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE40027.1 - 7.2e-12 44.9 6.5 1.3e-11 44.0 6.5 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MTHFR PF02219.17 EFE40028.1 - 8.4e-102 340.4 0.0 1.4e-101 339.6 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase FLILHELTA PF10306.9 EFE40029.1 - 5.4e-30 103.6 0.0 9e-30 102.9 0.0 1.3 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 EFE40029.1 - 0.0055 17.2 0.2 0.0071 16.9 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) NDK PF00334.19 EFE40030.1 - 1.8e-23 83.0 0.0 2.4e-17 63.2 0.0 2.0 1 1 1 2 2 2 2 Nucleoside diphosphate kinase TMEM141 PF15110.6 EFE40030.1 - 0.17 12.5 0.0 0.29 11.8 0.0 1.3 1 0 0 1 1 1 0 TMEM141 protein family Glyco_hydro_31 PF01055.26 EFE40031.1 - 2e-138 462.3 9.1 3.7e-138 461.4 9.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EFE40031.1 - 1.5e-26 92.5 0.6 1.2e-25 89.6 0.2 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EFE40031.1 - 5.3e-08 33.0 0.2 2.1e-07 31.1 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) NMT1 PF09084.11 EFE40033.1 - 0.0013 18.7 0.0 0.018 15.0 0.0 2.2 1 1 1 2 2 2 1 NMT1/THI5 like SBP_bac_3 PF00497.20 EFE40033.1 - 0.0062 16.0 0.0 0.017 14.6 0.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1_3 PF16868.5 EFE40033.1 - 0.013 15.0 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 NMT1-like family GhoS PF11080.8 EFE40033.1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.7 2 0 0 2 2 2 0 Endoribonuclease GhoS Phosphonate-bd PF12974.7 EFE40033.1 - 0.16 11.6 0.0 0.5 9.9 0.0 1.8 2 0 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Phe_hydrox_dim PF07976.12 EFE40034.1 - 2.3e-25 89.6 0.0 4.8e-25 88.5 0.0 1.5 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_3 PF01494.19 EFE40034.1 - 2.3e-08 33.7 0.0 3.5e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 EFE40035.1 - 6.6e-30 104.5 0.0 3.2e-28 99.0 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Glyco_hydro_16 PF00722.21 EFE40036.1 - 1.5e-06 27.8 0.1 3.5e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Ribosomal_L1 PF00687.21 EFE40037.1 - 3.2e-31 108.7 0.0 5.4e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family COG2 PF06148.11 EFE40038.1 - 4.3e-30 104.5 0.9 9.1e-30 103.5 0.9 1.5 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EFE40038.1 - 1.3e-05 25.2 2.0 2.8e-05 24.1 0.3 2.4 1 1 1 2 2 2 1 Vps51/Vps67 COG5 PF10392.9 EFE40038.1 - 0.026 14.7 0.4 0.026 14.7 0.4 1.8 2 1 0 2 2 2 0 Golgi transport complex subunit 5 Sec8_exocyst PF04048.14 EFE40038.1 - 0.027 14.4 0.4 0.061 13.2 0.4 1.6 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EFE40038.1 - 0.037 13.3 0.4 0.068 12.4 0.1 1.5 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex Atg14 PF10186.9 EFE40038.1 - 0.044 12.9 2.9 0.065 12.3 2.9 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 KxDL PF10241.9 EFE40038.1 - 0.048 13.9 0.8 0.16 12.3 0.8 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein Spc7 PF08317.11 EFE40038.1 - 0.055 12.3 3.2 0.09 11.6 3.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Dor1 PF04124.12 EFE40038.1 - 0.06 12.0 1.3 0.083 11.6 1.3 1.2 1 0 0 1 1 1 0 Dor1-like family Bul1_C PF04426.12 EFE40038.1 - 0.12 11.7 0.9 4.5 6.6 0.1 2.2 1 1 1 2 2 2 0 Bul1 C terminus FTCD_C PF04961.12 EFE40038.1 - 0.16 11.7 0.2 0.63 9.8 0.0 1.9 1 1 1 2 2 2 0 Formiminotransferase-cyclodeaminase Sds3 PF08598.11 EFE40038.1 - 0.29 11.1 6.3 0.55 10.2 6.3 1.4 1 1 0 1 1 1 0 Sds3-like UPF0242 PF06785.11 EFE40038.1 - 0.37 10.9 4.9 0.79 9.8 3.7 2.0 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF1690 PF07956.11 EFE40038.1 - 0.93 9.9 5.3 0.3 11.5 2.1 1.8 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) Seryl_tRNA_N PF02403.22 EFE40038.1 - 1.2 9.4 5.5 3.1 8.1 0.4 2.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Fez1 PF06818.15 EFE40038.1 - 3.8 7.9 7.4 0.88 10.0 0.9 2.3 2 1 1 3 3 2 0 Fez1 Herpes_TAF50 PF03326.13 EFE40039.1 - 1.7 7.2 8.3 1.6 7.3 1.4 2.4 3 0 0 3 3 3 0 Herpesvirus transcription activation factor (transactivator) ParA PF10609.9 EFE40041.1 - 8.2e-85 284.2 0.1 4.6e-59 199.8 0.0 2.1 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFE40041.1 - 1.2e-09 38.4 0.0 2.2e-09 37.4 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EFE40041.1 - 1e-05 25.0 0.0 6.9e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.6 EFE40041.1 - 1.4e-05 25.1 0.1 0.00047 20.1 0.1 2.1 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 EFE40041.1 - 0.00039 19.7 0.1 0.0019 17.4 0.3 1.9 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_25 PF13481.6 EFE40041.1 - 0.00088 18.9 0.1 0.0015 18.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_26 PF13500.6 EFE40041.1 - 0.0064 16.3 0.4 1.3 8.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EFE40041.1 - 0.019 14.0 0.2 0.03 13.3 0.2 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CBP_BcsQ PF06564.12 EFE40041.1 - 0.03 13.8 0.2 0.14 11.6 0.1 1.9 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ OrfB_Zn_ribbon PF07282.11 EFE40041.1 - 0.094 12.6 0.3 0.18 11.8 0.3 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain APS_kinase PF01583.20 EFE40041.1 - 0.14 12.0 0.1 0.22 11.4 0.1 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase CLP1_P PF16575.5 EFE40041.1 - 0.15 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SEP PF08059.13 EFE40042.1 - 3.3e-23 82.1 0.1 7.4e-23 80.9 0.1 1.6 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 EFE40042.1 - 5.5e-14 52.1 0.0 8.6e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EFE40042.1 - 8.3e-07 28.7 0.1 6.2e-06 25.9 0.1 2.1 1 1 0 1 1 1 1 UBA-like domain 60KD_IMP PF02096.20 EFE40043.1 - 1.4e-20 73.9 0.1 2.2e-20 73.2 0.1 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein DUF5326 PF17260.2 EFE40043.1 - 0.077 13.1 0.4 0.14 12.3 0.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5326) TAFII28 PF04719.14 EFE40044.1 - 3.7e-29 100.7 0.3 2e-26 91.9 0.1 2.3 2 0 0 2 2 2 2 hTAFII28-like protein conserved region FAD_binding_3 PF01494.19 EFE40046.1 - 1.2e-10 41.2 4.2 0.00026 20.3 2.1 2.8 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EFE40046.1 - 1.1e-06 28.1 0.8 0.0051 16.1 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFE40046.1 - 2.6e-06 26.8 0.2 5e-06 25.9 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFE40046.1 - 0.0012 17.6 0.9 0.0035 16.1 0.4 1.8 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EFE40046.1 - 0.0028 17.3 4.8 0.17 11.4 1.1 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EFE40046.1 - 0.0066 15.8 0.4 0.012 15.0 0.4 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 EFE40046.1 - 0.013 15.8 0.2 0.031 14.5 0.2 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EFE40046.1 - 0.018 14.1 0.3 0.029 13.5 0.3 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFE40046.1 - 0.032 13.6 0.2 0.049 13.0 0.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_DMAT PF11991.8 EFE40047.1 - 3.6e-104 349.1 0.0 4.2e-104 348.8 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Pkinase PF00069.25 EFE40048.1 - 1.1e-19 70.9 0.0 7.2e-19 68.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40048.1 - 9e-06 25.1 0.0 0.0049 16.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE40048.1 - 0.036 12.8 0.0 0.05 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase WLM PF08325.10 EFE40049.1 - 3.2e-67 226.3 0.1 5.6e-67 225.5 0.1 1.4 1 0 0 1 1 1 1 WLM domain zf-RanBP PF00641.18 EFE40049.1 - 3.4e-05 23.1 1.3 3.4e-05 23.1 1.3 3.1 2 1 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF45 PF01863.17 EFE40049.1 - 0.0038 17.3 2.0 0.0081 16.2 2.0 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF45 SprT-like PF10263.9 EFE40049.1 - 0.013 15.3 0.1 0.025 14.4 0.1 1.5 1 0 0 1 1 1 0 SprT-like family Peptidase_M54 PF07998.11 EFE40049.1 - 0.021 14.8 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 DZR PF12773.7 EFE40049.1 - 0.51 10.4 7.8 3.7 7.6 2.5 2.4 2 0 0 2 2 2 0 Double zinc ribbon C1_2 PF03107.16 EFE40049.1 - 1.8 8.9 6.1 17 5.8 1.0 2.8 2 0 0 2 2 2 0 C1 domain SVIP PF15811.5 EFE40049.1 - 3.9 8.0 6.3 27 5.3 0.9 2.9 2 0 0 2 2 2 0 Small VCP/p97-interacting protein DUF1776 PF08643.10 EFE40051.1 - 2.7e-73 246.9 0.2 3.2e-52 177.8 0.1 2.0 1 1 1 2 2 2 2 Fungal family of unknown function (DUF1776) adh_short PF00106.25 EFE40051.1 - 0.0031 17.0 0.0 0.017 14.5 0.0 1.7 1 1 1 2 2 2 1 short chain dehydrogenase Band_7 PF01145.25 EFE40051.1 - 0.15 12.1 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 SPFH domain / Band 7 family 7tm_7 PF08395.12 EFE40052.1 - 0.93 8.6 15.2 0.92 8.6 13.6 1.7 1 1 1 2 2 2 0 7tm Chemosensory receptor Myc_target_1 PF15179.6 EFE40053.1 - 0.41 10.5 0.0 0.41 10.5 0.0 2.2 2 0 0 2 2 2 0 Myc target protein 1 SOG2 PF10428.9 EFE40053.1 - 0.52 9.4 1.5 0.51 9.5 1.5 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Glyco_hydro_18 PF00704.28 EFE40054.1 - 2.8e-20 73.3 0.8 4e-19 69.5 0.8 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 DUF4849 PF16141.5 EFE40054.1 - 0.018 14.3 0.4 0.086 12.1 0.4 2.1 1 1 0 1 1 1 0 Putative glycoside hydrolase Family 18, chitinase_18 GDI PF00996.18 EFE40054.1 - 0.07 11.6 0.0 0.091 11.3 0.0 1.1 1 0 0 1 1 1 0 GDP dissociation inhibitor Sel1 PF08238.12 EFE40055.1 - 3.1e-11 43.5 11.9 0.00022 21.8 2.4 4.1 4 0 0 4 4 4 3 Sel1 repeat DUF913 PF06025.12 EFE40056.1 - 0.095 11.7 1.5 0.099 11.6 1.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CLN3 PF02487.17 EFE40056.1 - 0.31 10.1 0.6 0.33 9.9 0.6 1.1 1 0 0 1 1 1 0 CLN3 protein MCM_bind PF09739.9 EFE40056.1 - 0.35 9.3 8.1 0.38 9.2 8.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Rtf2 PF04641.12 EFE40056.1 - 0.36 10.1 11.5 0.44 9.9 11.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Moulting_cycle PF04870.16 EFE40056.1 - 0.83 8.9 13.6 0.98 8.6 13.6 1.0 1 0 0 1 1 1 0 Moulting cycle ALMT PF11744.8 EFE40056.1 - 0.88 8.3 2.9 0.92 8.3 2.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter GAGA_bind PF06217.12 EFE40056.1 - 1.1 9.4 10.3 1.3 9.2 10.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family FAM176 PF14851.6 EFE40056.1 - 1.1 8.9 15.9 1.6 8.4 15.9 1.2 1 0 0 1 1 1 0 FAM176 family Ribosomal_60s PF00428.19 EFE40056.1 - 1.6 9.4 9.2 0.1 13.2 2.1 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Coilin_N PF15862.5 EFE40056.1 - 1.7 8.5 16.8 0.08 12.7 11.6 1.5 2 0 0 2 2 2 0 Coilin N-terminus Presenilin PF01080.17 EFE40056.1 - 2.6 6.7 10.8 3 6.5 10.8 1.0 1 0 0 1 1 1 0 Presenilin OAD_gamma PF04277.13 EFE40056.1 - 5.8 7.6 5.2 11 6.7 5.2 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain AP3D1 PF06375.11 EFE40056.1 - 7 6.9 21.8 8.9 6.5 21.8 1.3 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 Hid1 PF12722.7 EFE40056.1 - 7.7 4.5 7.3 8.4 4.4 7.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 EFE40056.1 - 8.1 6.2 13.5 9.6 5.9 13.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPAT_C PF15712.5 EFE40056.1 - 9 4.8 10.5 10 4.6 10.5 1.0 1 0 0 1 1 1 0 NPAT C terminus DUF3712 PF12505.8 EFE40057.1 - 9.6e-34 116.3 5.2 1.5e-33 115.7 3.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) DUF4307 PF14155.6 EFE40057.1 - 0.082 12.7 0.5 0.17 11.8 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) Glyco_hydro_18 PF00704.28 EFE40058.1 - 1.4e-70 238.5 0.0 1.7e-70 238.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 zf-CCCH PF00642.24 EFE40059.1 - 3.2e-19 68.3 29.7 2.2e-06 27.4 0.7 5.3 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFE40059.1 - 1.5e-11 43.9 33.7 0.00058 19.8 2.5 5.2 5 0 0 5 5 5 4 Zinc finger domain Torus PF16131.5 EFE40059.1 - 1.3e-08 35.4 28.3 0.00022 21.9 1.0 5.4 1 1 4 5 5 5 5 Torus domain zf-CCCH_4 PF18044.1 EFE40059.1 - 4.1e-05 23.3 0.8 4.1e-05 23.3 0.8 5.0 5 0 0 5 5 5 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EFE40059.1 - 0.11 12.7 11.5 6.4 7.0 4.1 3.5 2 1 1 3 3 3 0 Zinc-finger containing family TRP_N PF14558.6 EFE40059.1 - 0.38 11.1 3.5 16 5.9 0.0 3.1 2 1 1 3 3 3 0 ML-like domain zf-C3H1 PF10650.9 EFE40059.1 - 3.2 7.6 11.2 1.2 9.0 0.4 3.5 3 0 0 3 3 3 0 Putative zinc-finger domain Syja_N PF02383.18 EFE40060.1 - 5.9e-89 298.5 0.0 7.4e-89 298.2 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain FUN14 PF04930.15 EFE40060.1 - 0.025 15.0 0.1 1.4 9.4 0.0 3.0 3 0 0 3 3 3 0 FUN14 family Mur_ligase_M PF08245.12 EFE40061.1 - 7.6e-07 29.3 0.2 0.00016 21.7 0.1 3.1 1 1 1 2 2 2 2 Mur ligase middle domain NMT PF01233.19 EFE40062.1 - 6.2e-22 78.2 0.3 9.1e-22 77.6 0.3 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 EFE40063.1 - 5.6e-77 258.0 3.4 6.4e-77 257.8 3.4 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain TLD PF07534.16 EFE40064.1 - 1.8e-21 76.8 0.0 3.2e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 TLD DUF1773 PF08593.10 EFE40064.1 - 0.00029 21.8 0.2 0.00071 20.6 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function Abhydrolase_6 PF12697.7 EFE40066.1 - 2e-12 48.2 0.3 3.3e-12 47.5 0.3 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFE40066.1 - 3.7e-08 32.9 0.0 7e-08 32.0 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFE40066.1 - 1.7e-07 31.2 0.0 2.2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EFE40066.1 - 0.00013 21.9 0.0 0.00021 21.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF818 PF05677.12 EFE40066.1 - 0.0035 16.4 0.0 0.0055 15.7 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.21 EFE40066.1 - 0.088 12.3 0.0 0.23 10.9 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family DMSP_lyase PF16867.5 EFE40066.1 - 0.18 11.4 0.3 0.49 10.0 0.0 1.8 2 0 0 2 2 2 0 Dimethlysulfonioproprionate lyase GTP_EFTU PF00009.27 EFE40067.1 - 2.2e-58 197.0 0.4 4.2e-58 196.1 0.4 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFE40067.1 - 2.7e-33 114.3 0.0 5.9e-33 113.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EFE40067.1 - 2.2e-32 111.0 0.0 4.5e-32 110.0 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EFE40067.1 - 1.6e-24 85.8 0.0 3.8e-24 84.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFE40067.1 - 1.7e-11 44.3 0.0 4.6e-11 42.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EFE40067.1 - 1.6e-05 24.7 0.0 3.6e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain ATP_bind_1 PF03029.17 EFE40067.1 - 0.025 14.4 0.1 0.099 12.4 0.1 2.0 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein PALP PF00291.25 EFE40068.1 - 8.8e-70 235.4 0.8 2.5e-69 233.9 0.8 1.7 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EFE40068.1 - 2.1e-41 139.6 0.0 2.3e-19 69.0 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase HIG_1_N PF04588.13 EFE40069.1 - 7.8e-30 102.9 0.6 1.1e-29 102.4 0.6 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Acetyltransf_1 PF00583.25 EFE40070.1 - 1.5e-12 47.7 0.0 2.1e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE40070.1 - 1.9e-09 37.6 0.0 5e-09 36.2 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE40070.1 - 2.5e-09 37.4 0.0 3.8e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE40070.1 - 3.5e-06 26.9 0.0 6.6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EFE40070.1 - 0.0016 18.6 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFE40070.1 - 0.0077 16.9 0.0 0.011 16.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Pescadillo_N PF06732.11 EFE40071.1 - 2e-97 326.0 0.0 2e-97 326.0 0.0 2.2 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EFE40071.1 - 0.0016 18.8 0.0 0.0069 16.8 0.0 2.1 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFE40071.1 - 0.029 14.7 0.0 0.69 10.3 0.0 2.9 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain DUF2457 PF10446.9 EFE40071.1 - 7.2 5.6 36.9 13 4.8 36.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RRN9 PF10680.9 EFE40072.1 - 4.8e-23 81.2 0.4 1.6e-22 79.6 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor zf-C2H2 PF00096.26 EFE40072.1 - 0.13 12.8 0.1 0.33 11.5 0.1 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type Aldedh PF00171.22 EFE40073.1 - 3.9e-158 526.8 0.2 4.8e-158 526.5 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Raffinose_syn PF05691.12 EFE40074.1 - 3.3e-54 183.9 2.0 3.1e-50 170.8 1.5 4.2 2 1 0 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 SnAC PF14619.6 EFE40074.1 - 0.052 14.2 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Snf2-ATP coupling, chromatin remodelling complex tRNA-synt_1b PF00579.25 EFE40075.1 - 2.9e-56 190.9 0.0 3.9e-56 190.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 EFE40075.1 - 6.3e-44 148.6 0.0 1.2e-43 147.7 0.0 1.5 1 0 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain MutS_V PF00488.21 EFE40076.1 - 7.2e-67 225.1 0.1 1.3e-66 224.2 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFE40076.1 - 5.5e-42 144.2 0.1 1.1e-41 143.2 0.1 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EFE40076.1 - 4.4e-33 113.9 0.1 2.2e-32 111.7 0.1 2.2 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 EFE40076.1 - 2.1e-15 56.8 1.8 6e-15 55.4 1.8 1.9 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EFE40076.1 - 3.4e-12 46.8 0.0 1.2e-11 45.1 0.0 2.0 1 0 0 1 1 1 1 MutS domain II AAA_23 PF13476.6 EFE40076.1 - 0.0028 18.2 4.2 0.025 15.1 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_27 PF13514.6 EFE40076.1 - 0.018 14.6 0.0 0.047 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFE40076.1 - 0.068 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 EFE40076.1 - 0.23 11.2 3.0 0.14 11.9 0.2 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Peptidase_M28 PF04389.17 EFE40078.1 - 1.1e-29 103.5 0.0 1.9e-29 102.8 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M28 Sulf_transp PF04143.14 EFE40079.1 - 1.5e-06 28.0 17.4 2.3e-05 24.1 3.5 3.3 3 0 0 3 3 3 3 Sulphur transport DUF3040 PF11239.8 EFE40079.1 - 3.2 8.1 5.4 16 5.8 0.0 3.9 5 0 0 5 5 5 0 Protein of unknown function (DUF3040) LigD_N PF13298.6 EFE40080.1 - 8.5e-28 96.7 0.0 1.5e-27 95.9 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase Ligase (LigD) Acetyltransf_6 PF13480.7 EFE40080.1 - 0.069 13.3 1.5 0.2 11.8 1.3 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3420 PF11900.8 EFE40080.1 - 0.68 10.1 3.6 2.7 8.2 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3420) PhoD PF09423.10 EFE40081.1 - 6.2e-102 341.2 0.2 8.7e-102 340.7 0.2 1.2 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 EFE40081.1 - 6.6e-35 119.5 0.1 1.6e-34 118.3 0.1 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 EFE40081.1 - 4.6e-05 23.9 0.2 0.00013 22.4 0.2 1.8 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain ABC_tran PF00005.27 EFE40082.1 - 6.4e-49 166.0 0.0 1.6e-31 109.7 0.0 2.8 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFE40082.1 - 8.5e-37 127.3 35.2 1.8e-25 90.1 13.7 3.1 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EFE40082.1 - 3.9e-12 46.1 0.0 0.0064 16.0 0.0 4.3 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFE40082.1 - 1e-07 32.7 0.8 4.1e-05 24.2 0.2 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFE40082.1 - 1.6e-06 28.4 0.2 1.1 9.5 0.0 4.3 4 0 0 4 4 4 2 AAA domain AAA_29 PF13555.6 EFE40082.1 - 0.00018 21.2 3.1 0.052 13.3 0.1 3.0 3 0 0 3 3 3 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFE40082.1 - 0.00035 20.5 0.0 0.76 9.7 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFE40082.1 - 0.00041 20.4 0.3 0.065 13.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase T2SSE PF00437.20 EFE40082.1 - 0.00064 18.9 0.0 0.074 12.1 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 EFE40082.1 - 0.0015 19.0 1.0 1.5 9.2 0.0 3.4 3 0 0 3 3 2 1 AAA ATPase domain AAA_21 PF13304.6 EFE40082.1 - 0.0047 16.8 0.1 11 5.7 0.0 3.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EFE40082.1 - 0.0066 16.6 2.5 0.85 9.7 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain IstB_IS21 PF01695.17 EFE40082.1 - 0.0073 16.0 0.2 0.7 9.6 0.0 3.1 3 0 0 3 3 3 1 IstB-like ATP binding protein Zeta_toxin PF06414.12 EFE40082.1 - 0.013 14.8 0.1 2.9 7.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 EFE40082.1 - 0.064 13.0 0.9 21 4.8 0.1 3.1 3 0 0 3 3 3 0 AAA domain Orthoreo_P10 PF07204.11 EFE40082.1 - 0.069 13.1 0.7 25 4.9 0.6 3.3 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 MeaB PF03308.16 EFE40082.1 - 0.088 11.8 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 EFE40082.1 - 0.09 12.5 0.4 5.2 6.7 0.3 2.2 2 0 0 2 2 2 0 AAA ATPase domain DUF2075 PF09848.9 EFE40082.1 - 0.11 11.7 0.1 1.4 8.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 EFE40082.1 - 0.17 11.9 0.9 27 4.8 0.5 2.6 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain UL45 PF05473.12 EFE40082.1 - 0.18 11.4 0.2 0.41 10.3 0.2 1.6 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like AAA_25 PF13481.6 EFE40082.1 - 0.19 11.3 0.1 20 4.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain PEP_mutase PF13714.6 EFE40083.1 - 5.4e-67 225.7 1.2 6.1e-67 225.5 1.2 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DUF2340 PF10209.9 EFE40084.1 - 0.072 13.6 0.0 0.082 13.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) Oxidored_q2 PF00420.24 EFE40085.1 - 0.01 15.5 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Rogdi_lz PF10259.9 EFE40085.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.0 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein tRNA-synt_2 PF00152.20 EFE40086.1 - 1.8e-88 296.6 0.0 3.7e-88 295.6 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFE40086.1 - 1.4e-05 25.0 0.1 3.8e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.25 EFE40086.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 EFE40086.1 - 0.17 11.4 0.0 0.45 9.9 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) ABC2_membrane PF01061.24 EFE40087.1 - 9e-27 93.9 26.9 1.3e-26 93.4 26.9 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFE40087.1 - 4.7e-26 91.9 0.2 2.4e-25 89.7 0.1 2.0 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EFE40087.1 - 1.1e-06 28.8 0.1 0.043 13.6 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFE40087.1 - 2.1e-05 23.8 14.4 2.8e-05 23.4 14.4 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFE40087.1 - 2.2e-05 24.4 0.0 4.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EFE40087.1 - 0.00018 22.0 0.4 0.0011 19.4 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EFE40087.1 - 0.0025 17.4 0.0 0.0057 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFE40087.1 - 0.0064 15.6 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein cobW PF02492.19 EFE40087.1 - 0.0073 15.9 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EFE40087.1 - 0.0088 15.8 0.1 0.019 14.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFE40087.1 - 0.0094 15.7 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFE40087.1 - 0.0098 16.3 0.0 0.095 13.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFE40087.1 - 0.0099 16.2 0.1 0.032 14.5 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_13 PF13166.6 EFE40087.1 - 0.01 14.5 0.1 0.01 14.5 0.1 2.4 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.15 EFE40087.1 - 0.012 15.6 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 EFE40087.1 - 0.016 15.8 0.0 0.042 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 EFE40087.1 - 0.019 14.4 0.7 0.032 13.7 0.0 1.6 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 EFE40087.1 - 0.027 14.2 0.0 0.056 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 EFE40087.1 - 0.034 14.4 0.0 0.065 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFE40087.1 - 0.06 13.8 0.8 0.29 11.6 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFE40087.1 - 0.065 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFE40087.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 EFE40087.1 - 0.1 12.5 0.1 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EFE40087.1 - 0.13 12.7 0.0 0.79 10.1 0.0 2.2 2 0 0 2 2 2 0 RNA helicase Zn_clus PF00172.18 EFE40088.1 - 2e-08 34.2 4.4 4e-08 33.3 4.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFE40088.1 - 2.1e-06 27.0 0.0 5e-06 25.7 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain GFA PF04828.14 EFE40089.1 - 4.7e-19 68.5 0.8 4.7e-19 68.5 0.8 1.9 2 1 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme INPP5B_PH PF16776.5 EFE40089.1 - 0.098 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain ThiS PF02597.20 EFE40090.1 - 0.00039 21.0 0.0 0.0037 17.9 0.0 1.9 1 1 0 1 1 1 1 ThiS family Cys_Met_Meta_PP PF01053.20 EFE40091.1 - 2.1e-61 207.6 0.0 9.2e-61 205.5 0.0 2.0 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFE40091.1 - 0.011 14.7 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V TRP PF06011.12 EFE40094.1 - 2.3e-39 135.4 20.1 2.5e-37 128.6 20.1 2.2 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EFE40094.1 - 6.6e-16 58.9 0.1 1.1e-15 58.3 0.1 1.3 1 0 0 1 1 1 1 ML-like domain Strabismus PF06638.11 EFE40094.1 - 3.9 6.0 5.5 6.2 5.3 5.5 1.2 1 0 0 1 1 1 0 Strabismus protein APH PF01636.23 EFE40095.1 - 2.7e-15 57.0 0.1 8.7e-15 55.3 0.0 1.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family DNA_binding_1 PF01035.20 EFE40096.1 - 3.1e-24 84.9 0.0 4.4e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Rubella_Capsid PF05750.11 EFE40096.1 - 0.0033 17.1 0.1 0.0054 16.4 0.0 1.4 2 0 0 2 2 2 1 Rubella capsid protein Pyr_redox_2 PF07992.14 EFE40097.1 - 4.7e-67 226.3 7.3 7.4e-67 225.6 7.3 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Sugar_tr PF00083.24 EFE40097.1 - 1.7e-64 218.4 16.2 2.4e-44 152.0 1.7 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter Pyr_redox_dim PF02852.22 EFE40097.1 - 8.7e-39 132.2 0.1 1.9e-38 131.1 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFE40097.1 - 1.6e-21 76.7 7.8 3.6e-20 72.3 1.0 3.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EFE40097.1 - 2.5e-13 49.7 31.4 3e-07 29.7 8.0 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily FAD_oxidored PF12831.7 EFE40097.1 - 3.3e-10 39.9 9.6 3.4e-10 39.8 0.3 3.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE40097.1 - 9.6e-09 35.4 4.6 7.6e-05 22.9 0.5 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EFE40097.1 - 1.8e-07 30.6 12.5 9.9e-07 28.2 4.6 2.7 2 2 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EFE40097.1 - 5.7e-07 29.1 7.0 3.8e-05 23.1 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFE40097.1 - 2.1e-06 27.1 2.5 2.1e-06 27.1 2.5 2.5 2 1 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 EFE40097.1 - 3.3e-06 26.5 4.0 0.0085 15.4 0.3 2.8 2 1 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 EFE40097.1 - 4.1e-05 22.9 0.7 0.26 10.4 0.0 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EFE40097.1 - 0.00024 19.9 13.6 0.0014 17.4 1.4 3.9 4 0 0 4 4 4 2 HI0933-like protein Thi4 PF01946.17 EFE40097.1 - 0.00027 20.3 4.3 0.0011 18.3 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EFE40097.1 - 0.0018 17.4 2.2 0.055 12.5 0.0 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein DAO PF01266.24 EFE40097.1 - 0.0024 17.5 15.4 0.16 11.5 1.4 3.8 4 0 0 4 4 4 2 FAD dependent oxidoreductase THF_DHG_CYH_C PF02882.19 EFE40097.1 - 0.085 12.2 2.1 0.41 10.0 0.1 2.7 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain FAD_binding_3 PF01494.19 EFE40097.1 - 0.14 11.3 11.2 0.48 9.6 1.3 3.3 3 1 0 3 3 3 0 FAD binding domain NAD_binding_7 PF13241.6 EFE40097.1 - 0.32 11.5 1.2 3.9 8.0 0.1 2.9 2 0 0 2 2 2 0 Putative NAD(P)-binding PGM_PMM_II PF02879.16 EFE40098.1 - 3.9e-17 62.8 0.1 9.9e-17 61.4 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EFE40098.1 - 7.3e-16 58.4 0.0 1.2e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EFE40098.1 - 1.3e-07 31.7 0.0 3.2e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Peripla_BP_4 PF13407.6 EFE40098.1 - 0.077 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Periplasmic binding protein domain PGM_PMM_I PF02878.16 EFE40099.1 - 2.9e-25 88.6 0.1 3.7e-25 88.2 0.1 1.1 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I FA_desaturase PF00487.24 EFE40100.1 - 3e-25 89.5 29.8 4.5e-25 88.9 29.8 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFE40100.1 - 5.7e-11 42.4 0.0 1.2e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PI-TkoII_IV PF18714.1 EFE40100.1 - 0.11 12.0 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 DNA polymerase II intein Domain IV CUE PF02845.16 EFE40101.1 - 7.2e-10 38.4 0.0 1.6e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 CUE domain Ribosomal_S10 PF00338.22 EFE40102.1 - 1e-26 93.0 0.3 1.2e-26 92.8 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Nucleoporin_FG PF13634.6 EFE40103.1 - 1.7 9.5 72.4 16 6.4 41.6 3.9 2 2 1 3 3 3 0 Nucleoporin FG repeat region ELYS PF13934.6 EFE40104.1 - 1.2e-61 208.5 0.0 2.4e-61 207.5 0.0 1.5 1 1 0 1 1 1 1 Nuclear pore complex assembly Peptidase_M75 PF09375.10 EFE40104.1 - 0.091 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Imelysin SMC_N PF02463.19 EFE40105.1 - 7.5e-72 241.3 17.1 2.6e-71 239.6 17.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFE40105.1 - 1.8e-24 86.3 0.1 1.2e-23 83.6 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EFE40105.1 - 2.6e-12 47.2 0.2 5.4e-05 23.1 0.0 3.0 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFE40105.1 - 3.4e-09 36.9 15.5 3.4e-09 36.9 15.5 3.8 2 2 1 3 3 3 1 AAA ATPase domain Tektin PF03148.14 EFE40105.1 - 0.00024 20.0 16.1 0.00024 20.0 16.1 5.6 3 2 1 5 5 5 2 Tektin family AAA_29 PF13555.6 EFE40105.1 - 0.00059 19.5 0.0 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Fib_alpha PF08702.10 EFE40105.1 - 0.0048 17.1 7.9 0.0048 17.1 7.9 6.8 2 2 3 6 6 6 2 Fibrinogen alpha/beta chain family ATG16 PF08614.11 EFE40105.1 - 0.0056 16.9 18.9 0.0056 16.9 18.9 7.5 4 2 3 7 7 7 2 Autophagy protein 16 (ATG16) SbcCD_C PF13558.6 EFE40105.1 - 0.025 14.8 0.2 1.2 9.4 0.0 3.5 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit RT_RNaseH PF17917.1 EFE40105.1 - 1.5 9.2 6.0 1.4 9.3 0.1 3.3 3 0 0 3 3 3 0 RNase H-like domain found in reverse transcriptase Fungal_trans PF04082.18 EFE40106.1 - 1.6e-10 40.5 0.3 5.1e-10 38.8 0.3 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE40106.1 - 3.9e-08 33.3 4.6 7.4e-08 32.4 4.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CDC45 PF02724.14 EFE40106.1 - 0.15 10.3 9.2 0.22 9.8 9.2 1.2 1 0 0 1 1 1 0 CDC45-like protein PAT1 PF09770.9 EFE40106.1 - 0.53 8.5 7.8 0.72 8.0 7.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Trypan_PARP PF05887.11 EFE40106.1 - 1.4 8.9 14.0 3 7.8 14.0 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Suc_Fer-like PF06999.12 EFE40107.1 - 2e-69 233.4 0.0 2.4e-69 233.1 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like DUF2487 PF10673.9 EFE40107.1 - 0.15 12.1 0.0 7.4 6.6 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2487) Ribonuc_L-PSP PF01042.21 EFE40108.1 - 1.9e-08 34.4 0.1 3.6e-08 33.4 0.1 1.5 1 0 0 1 1 1 1 Endoribonuclease L-PSP WD40 PF00400.32 EFE40108.1 - 8.9e-06 26.4 5.9 0.3 12.0 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat Fer4_13 PF13370.6 EFE40109.1 - 0.55 10.8 3.5 4.8 7.8 0.0 3.7 3 2 2 5 5 5 0 4Fe-4S single cluster domain of Ferredoxin I Sugar_tr PF00083.24 EFE40110.1 - 7.5e-105 351.4 23.0 8.3e-105 351.2 23.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE40110.1 - 4.2e-24 85.1 38.1 1.2e-15 57.3 10.3 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily DIOX_N PF14226.6 EFE40111.1 - 1.3e-35 122.7 0.0 1e-33 116.6 0.0 2.4 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFE40111.1 - 1.7e-08 34.9 0.0 4e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GxGYxYP_C PF14323.6 EFE40111.1 - 0.048 13.5 0.0 0.079 12.8 0.0 1.2 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain MFS_1 PF07690.16 EFE40112.1 - 6e-37 127.4 48.7 6e-37 127.4 48.7 2.4 1 1 0 2 2 2 1 Major Facilitator Superfamily LacY_symp PF01306.19 EFE40112.1 - 0.00022 20.1 1.2 0.00022 20.1 1.2 2.6 2 1 0 2 2 2 1 LacY proton/sugar symporter DUF2254 PF10011.9 EFE40112.1 - 0.0011 17.8 0.0 0.0024 16.8 0.0 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2254) Sarcolipin PF05366.11 EFE40112.1 - 0.061 13.0 0.1 0.15 11.7 0.1 1.7 1 0 0 1 1 1 0 Sarcolipin DNA_primase_S PF01896.19 EFE40113.1 - 8.3e-62 208.4 0.1 1.4e-61 207.6 0.1 1.4 1 0 0 1 1 1 1 DNA primase small subunit CDC27 PF09507.10 EFE40113.1 - 6.8 6.0 13.9 11 5.3 13.9 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 MAM33 PF02330.16 EFE40114.1 - 3.9e-72 242.6 1.4 4.9e-72 242.3 1.4 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein DUF3567 PF12091.8 EFE40114.1 - 0.15 12.2 0.5 0.96 9.6 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3567) cobW PF02492.19 EFE40115.1 - 1.8e-47 161.2 6.0 3.9e-36 124.3 1.0 2.2 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFE40115.1 - 1.6e-21 76.0 0.1 4.1e-17 61.9 0.0 2.9 3 0 0 3 3 3 2 Cobalamin synthesis protein cobW C-terminal domain AAA_16 PF13191.6 EFE40115.1 - 0.0048 17.3 0.7 0.024 15.0 0.7 2.1 1 1 0 1 1 1 1 AAA ATPase domain MobB PF03205.14 EFE40115.1 - 0.017 15.0 0.1 0.017 15.0 0.1 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.6 EFE40115.1 - 0.024 14.8 0.0 0.18 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFE40115.1 - 0.044 13.8 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MeaB PF03308.16 EFE40115.1 - 0.062 12.3 0.6 2.3 7.1 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Viral_helicase1 PF01443.18 EFE40115.1 - 0.11 12.2 0.1 0.33 10.7 0.1 1.8 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 EFE40115.1 - 0.12 11.4 1.0 0.16 11.0 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 EFE40115.1 - 0.16 11.7 0.1 0.44 10.3 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Tma16 PF11176.8 EFE40116.1 - 1.2e-49 167.9 3.3 1.5e-49 167.6 3.3 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 XPG_N PF00752.17 EFE40117.1 - 4.2e-24 84.9 0.0 1.7e-22 79.8 0.0 2.9 3 0 0 3 3 3 1 XPG N-terminal domain XPG_I PF00867.18 EFE40117.1 - 2.6e-22 79.0 0.0 5.4e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 EFE40117.1 - 0.0049 16.4 0.0 0.0087 15.5 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing TPR_14 PF13428.6 EFE40117.1 - 0.11 13.4 0.2 0.38 11.7 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFE40117.1 - 0.15 12.2 0.0 0.37 11.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Ycf1 PF05758.12 EFE40118.1 - 0.94 7.3 4.6 1 7.2 4.6 1.0 1 0 0 1 1 1 0 Ycf1 Fig1 PF12351.8 EFE40119.1 - 1.4e-58 197.9 4.2 1.4e-58 197.9 4.2 1.9 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 EFE40119.1 - 2.2e-06 27.5 9.1 3.5e-06 26.8 9.1 1.3 1 1 0 1 1 1 1 SUR7/PalI family MLTD_N PF06474.12 EFE40119.1 - 0.72 10.1 6.9 0.32 11.2 3.0 2.3 2 0 0 2 2 2 0 MltD lipid attachment motif DUF898 PF05987.13 EFE40119.1 - 2.2 7.3 9.2 0.16 11.0 4.1 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) AdoMet_MTase PF07757.13 EFE40120.1 - 2.4e-36 124.5 0.0 7.3e-19 68.2 0.0 2.3 2 0 0 2 2 2 2 Predicted AdoMet-dependent methyltransferase SMC_N PF02463.19 EFE40121.1 - 1.6e-22 80.0 0.0 3.1e-22 79.1 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFE40121.1 - 4.4e-11 43.1 0.0 7.6e-08 32.5 0.0 3.3 2 2 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EFE40121.1 - 5.6e-11 43.3 25.7 5.6e-11 43.3 25.7 5.4 3 2 0 3 3 1 1 AAA domain AAA_29 PF13555.6 EFE40121.1 - 0.001 18.8 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFE40121.1 - 0.0016 18.3 5.2 0.068 13.0 0.0 3.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 EFE40121.1 - 0.036 13.6 2.0 0.76 9.3 0.0 3.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EFE40121.1 - 0.081 12.8 0.1 0.5 10.3 0.0 2.3 2 0 0 2 2 2 0 NACHT domain Snapin_Pallidin PF14712.6 EFE40121.1 - 0.11 12.9 52.9 1.4 9.4 2.5 7.7 4 2 3 7 7 6 0 Snapin/Pallidin Baculo_PEP_C PF04513.12 EFE40121.1 - 0.15 12.1 11.7 3.3 7.7 0.6 4.2 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Mso1_Sec1_bdg PF14475.6 EFE40121.1 - 0.16 11.6 1.4 0.49 10.0 1.4 1.9 1 0 0 1 1 1 0 Sec1-binding region of Mso1 AAA_27 PF13514.6 EFE40121.1 - 0.34 10.5 0.0 0.34 10.5 0.0 4.2 4 2 1 6 6 6 0 AAA domain ABC_tran PF00005.27 EFE40121.1 - 0.37 11.3 0.0 0.37 11.3 0.0 4.2 4 1 0 4 4 2 0 ABC transporter DUF725 PF05267.12 EFE40121.1 - 1.5 8.8 4.6 17 5.4 1.3 3.8 2 1 0 2 2 2 0 Protein of unknown function (DUF725) DUF4162 PF13732.6 EFE40121.1 - 8.1 7.2 11.4 1.6 9.5 0.9 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4162) RGS PF00615.19 EFE40122.1 - 1e-05 25.8 0.1 0.0015 18.8 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain Lipase_3 PF01764.25 EFE40123.1 - 2.6e-16 59.8 0.0 1e-13 51.4 0.0 2.5 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EFE40123.1 - 0.046 14.3 0.4 0.087 13.4 0.4 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFE40123.1 - 0.16 11.2 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 BBS2_C PF14782.6 EFE40124.1 - 0.0047 15.7 2.4 0.0058 15.4 2.4 1.1 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal Ntox28 PF15605.6 EFE40124.1 - 0.032 14.5 0.7 0.043 14.1 0.7 1.2 1 0 0 1 1 1 0 Bacterial toxin 28 DASH_Hsk3 PF08227.11 EFE40125.1 - 1.3e-20 73.5 4.5 1.7e-20 73.1 4.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Sec2p PF06428.11 EFE40125.1 - 0.07 13.1 0.3 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF2076 PF09849.9 EFE40125.1 - 1.3 9.0 9.0 7.1 6.6 9.0 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) FA_desaturase PF00487.24 EFE40126.1 - 4.1e-23 82.5 18.3 1.1e-22 81.1 18.3 1.7 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EFE40126.1 - 3.4e-09 37.0 0.0 8.4e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Rad51 PF08423.11 EFE40127.1 - 6e-40 137.1 0.0 1.9e-37 128.9 0.0 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 EFE40127.1 - 1.5e-06 27.9 0.0 2.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EFE40127.1 - 6.7e-06 25.6 0.1 2e-05 24.1 0.1 1.7 1 1 0 1 1 1 1 KaiC DUF1254 PF06863.12 EFE40127.1 - 0.0017 18.4 0.0 0.32 11.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1254) RecA PF00154.21 EFE40127.1 - 0.024 14.1 0.2 0.073 12.5 0.2 1.8 1 1 0 1 1 1 0 recA bacterial DNA recombination protein AAA_22 PF13401.6 EFE40127.1 - 0.057 13.7 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFE40127.1 - 0.098 12.4 0.0 0.22 11.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EFE40127.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.5 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 EFE40127.1 - 0.15 12.4 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain MFS_1 PF07690.16 EFE40128.1 - 1.7e-29 102.9 30.0 1e-28 100.3 30.1 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFE40128.1 - 0.0013 17.3 1.5 0.0019 16.7 1.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DAO PF01266.24 EFE40129.1 - 1.8e-38 133.0 0.1 2.1e-38 132.8 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFE40129.1 - 3.3e-05 23.3 0.0 5.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EFE40129.1 - 5.4e-05 23.3 0.4 0.00012 22.2 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFE40129.1 - 0.006 15.8 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Mqo PF06039.15 EFE40129.1 - 0.019 13.5 0.0 0.027 13.0 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) SecD-TM1 PF13721.6 EFE40129.1 - 0.026 15.0 0.0 0.046 14.2 0.0 1.3 1 0 0 1 1 1 0 SecD export protein N-terminal TM region Amino_oxidase PF01593.24 EFE40129.1 - 0.038 13.3 0.0 0.28 10.4 0.0 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EFE40129.1 - 0.038 13.1 0.7 0.079 12.0 0.6 1.6 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 EFE40129.1 - 0.04 13.9 0.0 0.26 11.3 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding La PF05383.17 EFE40130.1 - 1.5e-19 69.8 0.0 3.6e-19 68.6 0.0 1.7 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EFE40130.1 - 3.3e-05 23.6 0.1 8.9e-05 22.2 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Chitin_synth_2 PF03142.15 EFE40131.1 - 5.6e-24 84.7 4.2 3.4e-22 78.8 2.8 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EFE40131.1 - 5.9e-15 55.7 6.3 5.9e-15 55.7 6.3 2.4 2 2 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFE40131.1 - 3.4e-10 40.2 0.0 1.1e-09 38.6 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFE40131.1 - 0.015 15.2 0.0 2.9 7.7 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 CSM2 PF16834.5 EFE40132.1 - 0.018 14.6 0.0 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 Shu complex component Csm2, DNA-binding Aldolase_II PF00596.21 EFE40133.1 - 5.4e-44 150.3 0.1 7.1e-44 150.0 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF924 PF06041.11 EFE40134.1 - 0.07 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF924) DUF5304 PF17230.2 EFE40134.1 - 1.2 9.3 6.0 44 4.3 0.1 3.8 3 0 0 3 3 3 0 Family of unknown function (DUF5304) Med31 PF05669.12 EFE40135.1 - 8.3e-30 102.6 0.0 1.7e-29 101.6 0.0 1.5 1 0 0 1 1 1 1 SOH1 Pal1 PF08316.11 EFE40136.1 - 4.5e-47 160.3 0.9 4.5e-47 160.3 0.9 2.1 2 0 0 2 2 2 1 Pal1 cell morphology protein Xan_ur_permease PF00860.20 EFE40137.1 - 2.9e-14 52.6 8.4 3.8e-14 52.2 8.4 1.3 1 0 0 1 1 1 1 Permease family Sulfate_transp PF00916.20 EFE40137.1 - 9.3e-05 21.3 2.6 9.3e-05 21.3 2.6 1.9 1 1 1 2 2 2 1 Sulfate permease family Ldr_toxin PF13940.6 EFE40137.1 - 0.49 10.5 2.5 18 5.5 0.0 2.6 2 0 0 2 2 2 0 Toxin Ldr, type I toxin-antitoxin system MAGE PF01454.19 EFE40138.1 - 3e-49 167.6 0.4 1.8e-25 89.9 0.0 2.4 2 1 1 3 3 3 2 MAGE family Ank_5 PF13857.6 EFE40139.1 - 5.4e-05 23.4 0.0 0.56 10.6 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFE40139.1 - 5.9e-05 23.3 0.0 0.00013 22.2 0.0 1.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EFE40139.1 - 0.00017 21.8 0.0 0.00093 19.5 0.0 2.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 EFE40139.1 - 0.00022 21.7 0.0 0.00094 19.7 0.0 1.8 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE40139.1 - 0.00024 21.6 0.0 0.013 16.1 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Glyco_hydro_97 PF10566.9 EFE40139.1 - 0.018 14.4 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 Glycoside hydrolase 97 PPR PF01535.20 EFE40139.1 - 0.081 13.2 0.7 0.21 11.9 0.7 1.6 1 0 0 1 1 1 0 PPR repeat PhyH PF05721.13 EFE40140.1 - 1.2e-21 78.0 0.0 1.5e-21 77.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EFE40140.1 - 0.034 12.9 0.0 0.048 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) AA_permease_2 PF13520.6 EFE40141.1 - 1.3e-34 119.8 52.4 1.6e-34 119.5 52.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE40141.1 - 1.6e-06 27.0 45.1 2.1e-06 26.6 45.1 1.1 1 0 0 1 1 1 1 Amino acid permease NAD_binding_10 PF13460.6 EFE40142.1 - 0.00016 21.6 0.0 0.00034 20.5 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding CUE PF02845.16 EFE40142.1 - 0.02 14.6 0.2 2.7 7.8 0.0 2.5 2 0 0 2 2 2 0 CUE domain Aminotran_1_2 PF00155.21 EFE40143.1 - 3.5e-18 65.9 0.0 4.4e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EFE40143.1 - 0.00021 20.2 0.0 0.013 14.3 0.0 2.5 1 1 0 2 2 2 2 Alanine-glyoxylate amino-transferase Aminotran_5 PF00266.19 EFE40143.1 - 0.0044 16.0 0.0 0.0064 15.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFE40143.1 - 0.25 10.6 0.1 2.9 7.1 0.0 2.0 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family PhyH PF05721.13 EFE40144.1 - 8.5e-19 68.6 0.0 1.4e-18 67.9 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AMP-binding PF00501.28 EFE40145.1 - 2.4e-93 313.0 0.0 5.6e-93 311.8 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.26 EFE40145.1 - 8.8e-88 294.1 0.2 2.1e-87 292.9 0.1 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFE40145.1 - 1.8e-61 208.4 0.6 1.5e-60 205.4 1.1 2.0 2 0 0 2 2 2 1 Acyl transferase domain KR PF08659.10 EFE40145.1 - 1.5e-59 201.0 0.0 1e-56 191.7 0.0 2.8 2 0 0 2 2 2 2 KR domain NAD_binding_4 PF07993.12 EFE40145.1 - 5e-47 160.2 0.0 1.4e-45 155.4 0.0 2.9 2 1 0 2 2 2 1 Male sterility protein Ketoacyl-synt_C PF02801.22 EFE40145.1 - 4.8e-39 133.0 0.4 1.4e-38 131.5 0.4 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EFE40145.1 - 6.8e-22 77.6 0.0 5.5e-12 45.9 0.0 3.2 2 0 0 2 2 2 2 Phosphopantetheine attachment site Epimerase PF01370.21 EFE40145.1 - 5.1e-14 52.3 0.0 2e-08 34.0 0.0 2.4 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family KAsynt_C_assoc PF16197.5 EFE40145.1 - 1.4e-13 51.3 0.0 1.2e-11 45.0 0.0 2.9 3 0 0 3 3 2 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EFE40145.1 - 4.2e-09 36.1 0.0 3e-06 26.9 0.0 2.7 2 0 0 2 2 2 2 short chain dehydrogenase AMP-binding_C PF13193.6 EFE40145.1 - 2.1e-08 35.0 0.0 6.4e-08 33.5 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Polysacc_synt_2 PF02719.15 EFE40145.1 - 1.3e-06 27.8 0.0 0.023 13.9 0.0 2.4 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EFE40145.1 - 4.1e-06 26.4 0.0 0.00026 20.5 0.0 2.3 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFE40145.1 - 6.9e-05 22.0 0.0 0.038 13.0 0.0 2.4 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 EFE40145.1 - 0.00025 20.5 0.2 0.0005 19.5 0.2 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain NmrA PF05368.13 EFE40145.1 - 0.042 13.4 0.1 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 NmrA-like family Peptidase_S24 PF00717.23 EFE40146.1 - 1.8e-06 27.8 0.3 8.8e-06 25.6 0.3 2.0 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EFE40146.1 - 0.13 12.1 0.0 7.6 6.3 0.0 2.3 2 0 0 2 2 2 0 Signal peptidase, peptidase S26 Ank_2 PF12796.7 EFE40147.1 - 1.2e-11 45.0 0.0 1.7e-06 28.5 0.0 2.6 2 1 2 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFE40147.1 - 2.2e-06 27.6 0.1 0.0016 18.8 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFE40147.1 - 1.5e-05 25.5 0.1 4e-05 24.1 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EFE40147.1 - 0.0003 21.1 0.1 0.064 13.7 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFE40147.1 - 0.0029 17.9 0.2 0.02 15.2 0.0 2.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Macro PF01661.21 EFE40148.1 - 4e-34 117.2 0.0 7.5e-34 116.3 0.0 1.5 1 0 0 1 1 1 1 Macro domain Fungal_trans PF04082.18 EFE40149.1 - 1.1e-19 70.5 0.1 1.1e-19 70.5 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain BDV_P10 PF06515.11 EFE40149.1 - 0.0057 16.7 1.2 0.025 14.6 1.2 2.1 1 0 0 1 1 1 1 Borna disease virus P10 protein Na_Ca_ex PF01699.24 EFE40150.1 - 1.4e-37 129.0 36.4 7.2e-23 81.2 15.7 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein EpuA PF11772.8 EFE40150.1 - 0.073 12.8 0.5 0.073 12.8 0.5 3.1 3 0 0 3 3 3 0 DNA-directed RNA polymerase subunit beta GHMP_kinases_N PF00288.26 EFE40151.1 - 1.7e-15 57.0 1.8 4.1e-15 55.8 1.8 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFE40151.1 - 1.1e-07 32.1 0.0 2.4e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal MCM PF00493.23 EFE40152.1 - 2.4e-99 331.0 0.1 3.6e-99 330.4 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFE40152.1 - 7.3e-38 129.3 0.2 1.5e-37 128.3 0.2 1.5 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 EFE40152.1 - 6.1e-33 113.3 2.2 1.5e-32 112.1 2.2 1.7 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 EFE40152.1 - 3.1e-24 85.2 0.4 8.6e-24 83.8 0.4 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFE40152.1 - 1.2e-20 74.1 1.3 3.2e-20 72.7 0.3 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFE40152.1 - 7.2e-05 22.3 0.0 0.00037 19.9 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFE40152.1 - 0.0038 17.2 0.0 0.013 15.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFE40152.1 - 0.0057 16.5 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFE40152.1 - 0.018 14.7 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain GIDA_assoc PF13932.6 EFE40152.1 - 0.062 13.5 1.8 0.16 12.1 1.8 1.8 1 0 0 1 1 1 0 GidA associated domain Voltage_CLC PF00654.20 EFE40153.1 - 1.7e-88 297.3 26.9 1.7e-88 297.3 26.9 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EFE40153.1 - 1.1e-08 35.3 0.0 0.00087 19.7 0.1 2.6 2 0 0 2 2 2 2 CBS domain ATPase_gene1 PF09527.10 EFE40153.1 - 1.4 9.1 11.6 4.1 7.7 1.2 3.8 4 0 0 4 4 4 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter GNVR PF13807.6 EFE40154.1 - 0.14 12.1 0.2 1.2 9.1 0.0 2.4 1 1 2 3 3 3 0 G-rich domain on putative tyrosine kinase UCR_TM PF02921.14 EFE40155.1 - 7.9e-11 42.3 0.5 2.3e-10 40.8 0.5 1.8 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 EFE40155.1 - 3e-10 39.9 0.0 5e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain She9_MDM33 PF05546.11 EFE40156.1 - 7.6e-88 293.5 9.1 1.1e-87 293.0 9.1 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family MBD_C PF14048.6 EFE40156.1 - 0.02 15.6 0.0 0.07 13.8 0.0 2.0 1 0 0 1 1 1 0 C-terminal domain of methyl-CpG binding protein 2 and 3 PsbH PF00737.20 EFE40156.1 - 0.047 13.4 0.8 0.094 12.5 0.8 1.4 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein SKA1 PF07160.12 EFE40156.1 - 2 8.2 9.7 0.068 13.0 2.4 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Aminotran_1_2 PF00155.21 EFE40157.1 - 8.5e-29 100.8 0.0 2.6e-14 53.2 0.0 2.2 2 1 0 2 2 2 2 Aminotransferase class I and II RabGAP-TBC PF00566.18 EFE40157.1 - 0.023 14.4 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Fungal_trans PF04082.18 EFE40158.1 - 6.6e-10 38.5 1.7 6.6e-10 38.5 1.7 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain PNP_phzG_C PF10590.9 EFE40159.1 - 4e-21 74.8 4.4 5.3e-21 74.4 1.7 2.4 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EFE40159.1 - 3.6e-11 43.1 0.0 3.6e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 EFE40159.1 - 0.0081 16.8 0.1 0.074 13.7 0.1 2.2 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Vpu PF00558.19 EFE40159.1 - 0.075 12.8 0.3 2.9 7.7 0.0 2.4 2 0 0 2 2 2 0 Vpu protein ILVD_EDD PF00920.21 EFE40160.1 - 1.6e-209 696.8 2.2 1.8e-209 696.6 2.2 1.0 1 0 0 1 1 1 1 Dehydratase family DUF1610 PF07754.11 EFE40160.1 - 0.076 13.0 0.2 22 5.1 0.2 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF1610) Abhydrolase_1 PF00561.20 EFE40161.1 - 2.1e-14 53.8 0.0 4e-13 49.6 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE40161.1 - 1.7e-12 48.4 0.7 1.7e-12 48.4 0.7 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFE40161.1 - 8.8e-12 44.8 0.0 1e-10 41.3 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DSPc PF00782.20 EFE40161.1 - 1.4e-07 31.4 0.0 3.5e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PGAP1 PF07819.13 EFE40161.1 - 0.00022 21.0 0.1 0.00091 19.0 0.0 1.8 2 0 0 2 2 2 1 PGAP1-like protein Ser_hydrolase PF06821.13 EFE40161.1 - 0.00033 20.5 0.1 0.0006 19.7 0.1 1.3 1 0 0 1 1 1 1 Serine hydrolase LIDHydrolase PF10230.9 EFE40161.1 - 0.00057 19.5 0.0 0.00089 18.9 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Chlorophyllase2 PF12740.7 EFE40161.1 - 0.0006 18.8 0.0 0.0015 17.5 0.0 1.6 2 0 0 2 2 2 1 Chlorophyllase enzyme Y_phosphatase PF00102.27 EFE40161.1 - 0.00078 19.1 0.0 0.0068 16.0 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFE40161.1 - 0.0011 19.1 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate LCAT PF02450.15 EFE40161.1 - 0.0097 15.1 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Thioesterase PF00975.20 EFE40161.1 - 0.068 13.3 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.25 EFE40161.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF900 PF05990.12 EFE40161.1 - 0.18 11.3 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PAF-AH_p_II PF03403.13 EFE40161.1 - 0.38 9.2 0.7 0.93 7.9 0.1 1.7 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Ribosomal_S19e PF01090.19 EFE40162.1 - 5.5e-47 158.9 0.8 6.7e-47 158.6 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Aldo_ket_red PF00248.21 EFE40164.1 - 1.9e-36 125.8 0.0 4.3e-34 118.0 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family SCHIP-1 PF10148.9 EFE40164.1 - 0.0003 20.5 0.0 0.00042 20.0 0.0 1.2 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 Dev_Cell_Death PF10539.9 EFE40164.1 - 0.018 14.9 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Development and cell death domain REC1 PF18501.1 EFE40164.1 - 0.6 10.0 1.8 15 5.4 1.6 2.8 1 1 0 1 1 1 0 Alpha helical recognition lobe domain APH PF01636.23 EFE40165.1 - 4.4e-05 23.5 0.1 9.6e-05 22.4 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFE40165.1 - 0.13 11.5 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase eRF1_1 PF03463.15 EFE40166.1 - 4.4e-32 110.8 0.0 1.3e-31 109.3 0.0 1.7 1 1 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 EFE40166.1 - 1.2e-17 64.4 0.0 2.1e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 EFE40166.1 - 1.1e-15 58.1 0.0 3e-15 56.7 0.0 1.7 1 1 0 1 1 1 1 eRF1 domain 2 Myb_DNA-bind_4 PF13837.6 EFE40167.1 - 0.003 17.9 2.7 0.01 16.2 0.1 2.3 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain SRP-alpha_N PF04086.13 EFE40169.1 - 0.37 10.7 17.4 0.55 10.1 17.4 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Rtf2 PF04641.12 EFE40169.1 - 0.4 10.0 11.8 0.51 9.7 11.8 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger DUF3408 PF11888.8 EFE40169.1 - 0.7 10.0 15.4 2.7 8.1 10.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Noggin PF05806.12 EFE40169.1 - 1.7 8.5 9.0 2.8 7.8 9.0 1.3 1 0 0 1 1 1 0 Noggin Ribosomal_L3 PF00297.22 EFE40170.1 - 1.2e-172 574.0 10.1 1.8e-172 573.5 10.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L3 SKN1 PF03935.15 EFE40171.1 - 3.9e-214 711.7 0.0 5.5e-214 711.2 0.0 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) BCDHK_Adom3 PF10436.9 EFE40172.1 - 1e-52 178.2 0.0 1e-49 168.5 0.0 2.2 1 1 1 2 2 2 2 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EFE40172.1 - 1e-09 38.9 0.0 4.6e-09 36.8 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFE40172.1 - 0.019 14.8 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Activator_LAG-3 PF11498.8 EFE40172.1 - 0.18 10.8 0.1 0.28 10.1 0.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Ank_2 PF12796.7 EFE40174.1 - 4.4e-30 104.1 2.4 2e-09 37.9 0.1 4.3 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE40174.1 - 3.3e-20 72.2 4.0 6.6e-10 39.3 0.2 5.6 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE40174.1 - 4.1e-20 71.6 2.4 3.3e-06 27.2 0.0 6.0 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE40174.1 - 1.5e-18 64.9 2.5 0.0015 18.9 0.0 7.6 7 1 1 8 8 8 3 Ankyrin repeat Ank PF00023.30 EFE40174.1 - 2.8e-16 59.2 9.8 0.0009 19.6 0.1 7.0 6 1 1 7 7 7 4 Ankyrin repeat Helo_like_N PF17111.5 EFE40175.1 - 0.00015 21.2 0.2 0.00072 19.0 0.0 1.9 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins Exo70 PF03081.15 EFE40176.1 - 1.1e-87 294.6 0.0 1.7e-87 294.0 0.0 1.3 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Laminin_II PF06009.12 EFE40176.1 - 0.28 11.2 2.3 2.6 8.0 0.3 2.7 2 0 0 2 2 2 0 Laminin Domain II PLA2_B PF01735.18 EFE40177.1 - 1.6e-27 96.1 0.0 2.3e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain PPR_2 PF13041.6 EFE40178.1 - 4.9e-17 61.9 0.0 0.035 14.3 0.1 7.4 5 2 3 8 8 8 5 PPR repeat family PPR PF01535.20 EFE40178.1 - 5.5e-13 48.2 5.8 0.047 14.0 0.0 8.1 9 0 0 9 9 9 2 PPR repeat PPR_long PF17177.4 EFE40178.1 - 2.6e-11 43.3 0.0 0.0032 16.9 0.0 3.9 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 EFE40178.1 - 2.8e-11 43.3 0.6 0.28 11.3 0.0 6.8 5 2 2 7 7 7 4 Pentatricopeptide repeat domain TPR_7 PF13176.6 EFE40178.1 - 0.027 14.5 0.1 78 3.7 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Dak1_2 PF13684.6 EFE40178.1 - 0.041 13.0 0.0 0.068 12.2 0.0 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Frtz PF11768.8 EFE40178.1 - 0.053 11.8 0.0 0.086 11.1 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz TPR_12 PF13424.6 EFE40178.1 - 0.077 13.3 0.1 86 3.5 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat CNOT11 PF10155.9 EFE40178.1 - 0.16 12.1 0.1 4 7.6 0.0 2.6 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 11 MNE1 PF13762.6 EFE40178.1 - 0.21 11.6 0.1 2.4 8.1 0.1 2.7 4 0 0 4 4 4 0 Mitochondrial splicing apparatus component DSPc PF00782.20 EFE40179.1 - 1.5e-10 41.0 0.0 2.5e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFE40179.1 - 4.2e-06 26.5 0.0 1.1e-05 25.2 0.0 1.6 1 1 1 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFE40179.1 - 0.018 15.1 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EFE40179.1 - 0.023 14.7 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family AChE_tetra PF08674.10 EFE40179.1 - 0.068 12.9 0.3 0.22 11.2 0.3 1.9 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain CDKN3 PF05706.12 EFE40179.1 - 0.069 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) His_Phos_1 PF00300.22 EFE40180.1 - 5.5e-22 78.4 0.0 1.1e-21 77.5 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) F-box-like PF12937.7 EFE40182.1 - 1.4e-05 24.9 0.1 3.3e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE40182.1 - 0.033 14.1 0.0 0.1 12.5 0.0 1.9 1 0 0 1 1 1 0 F-box domain F-box_4 PF15966.5 EFE40182.1 - 0.052 13.4 0.2 0.11 12.3 0.0 1.7 2 0 0 2 2 2 0 F-box MFS_1 PF07690.16 EFE40183.1 - 6.7e-07 28.6 18.3 7.3e-07 28.4 18.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EFE40184.1 - 6.4e-14 51.6 20.9 8.4e-14 51.3 20.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily RRM_1 PF00076.22 EFE40186.1 - 3.1e-80 264.0 5.1 6e-22 77.2 0.2 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EFE40186.1 - 1.2e-26 92.7 0.1 5.8e-26 90.5 0.1 2.2 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EFE40186.1 - 4.4e-14 52.1 0.1 0.011 15.3 0.0 5.3 2 1 2 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFE40186.1 - 7.7e-07 29.1 0.7 5.5 7.2 0.0 5.5 5 1 0 5 5 5 2 RNA recognition motif RRM_occluded PF16842.5 EFE40186.1 - 7.7e-06 25.7 0.1 0.018 14.9 0.0 3.4 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 EFE40186.1 - 0.00075 19.5 10.7 0.18 11.8 2.2 5.0 5 1 0 5 5 5 1 RNA binding motif Nup35_RRM_2 PF14605.6 EFE40186.1 - 0.0013 18.7 0.4 40 4.3 0.0 4.8 5 0 0 5 5 5 0 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EFE40186.1 - 0.017 15.2 1.1 4.5 7.4 0.0 3.6 3 0 0 3 3 3 0 Limkain b1 OB_RNB PF08206.11 EFE40186.1 - 0.15 11.8 2.1 18 5.1 0.0 3.5 3 0 0 3 3 3 0 Ribonuclease B OB domain NPR3 PF03666.13 EFE40186.1 - 0.78 8.5 5.9 1.2 7.8 5.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_pol_Rpc4 PF05132.14 EFE40186.1 - 7.8 6.9 14.6 24 5.3 10.7 2.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 Fe-ADH PF00465.19 EFE40187.1 - 3.2e-23 82.1 0.0 5e-21 74.9 0.0 2.0 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase DAO PF01266.24 EFE40188.1 - 1e-38 133.9 0.0 1.1e-38 133.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Vps52 PF04129.12 EFE40189.1 - 4e-119 398.6 2.8 5.7e-119 398.1 2.8 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 EFE40189.1 - 2.8e-06 26.1 1.5 4e-06 25.5 1.5 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 MitMem_reg PF13012.6 EFE40189.1 - 0.0043 17.4 0.3 0.49 10.8 0.2 3.4 2 1 0 2 2 2 1 Maintenance of mitochondrial structure and function COG2 PF06148.11 EFE40189.1 - 0.093 12.8 0.2 0.39 10.8 0.0 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 eIF-5a PF01287.20 EFE40190.1 - 3.2e-27 94.4 1.1 4.6e-27 93.9 1.1 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EFE40190.1 - 0.0032 17.4 0.6 0.02 14.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain Lactamase_B_5 PF14597.6 EFE40190.1 - 0.098 12.1 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily zf-RRN7 PF11781.8 EFE40191.1 - 1.7e-06 27.6 6.0 3.4e-06 26.6 6.0 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Tli4_C PF18426.1 EFE40191.1 - 0.017 15.4 0.3 0.035 14.4 0.3 1.5 1 0 0 1 1 1 0 Tle cognate immunity protein 4 C-terminal domain Ribosomal_L40e PF01020.17 EFE40192.1 - 5.3e-31 106.3 11.0 8.1e-31 105.7 11.0 1.3 1 0 0 1 1 1 1 Ribosomal L40e family ubiquitin PF00240.23 EFE40192.1 - 2.4e-15 56.1 0.1 2.5e-14 52.8 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 EFE40192.1 - 0.019 14.8 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Yip1 PF04893.17 EFE40193.1 - 1.7e-15 57.1 17.3 3.5e-15 56.1 17.3 1.5 1 1 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 EFE40193.1 - 0.086 12.4 5.4 0.13 11.8 2.6 2.2 1 1 1 2 2 2 0 YIF1 DUF5585 PF17823.1 EFE40193.1 - 0.33 9.9 0.1 0.47 9.3 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) DUF2070 PF09843.9 EFE40193.1 - 9.4 4.4 9.2 12 4.0 9.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) RabGAP-TBC PF00566.18 EFE40194.1 - 7.3e-20 71.5 0.3 1.4e-19 70.6 0.3 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain MMS1_N PF10433.9 EFE40195.1 - 0.00024 19.9 0.0 0.0003 19.6 0.0 1.1 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term MMS1_N PF10433.9 EFE40196.1 - 2.3e-69 234.3 0.0 5.4e-69 233.1 0.0 1.5 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EFE40196.1 - 0.00063 19.1 0.0 0.0033 16.8 0.0 1.9 2 0 0 2 2 2 1 CPSF A subunit region GTP_EFTU PF00009.27 EFE40197.1 - 3.5e-34 118.0 0.1 5.3e-33 114.2 0.1 2.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EFE40197.1 - 7.2e-21 74.3 0.1 2.2e-20 72.8 0.1 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EFE40197.1 - 5.3e-10 39.5 4.2 7.9e-10 39.0 0.1 3.3 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EFE40197.1 - 2.5e-09 36.9 0.0 7.1e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EFE40197.1 - 5.5e-07 29.7 0.5 1e-05 25.5 0.0 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EFE40197.1 - 0.00054 20.2 0.0 0.0019 18.4 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EFE40197.1 - 0.0057 16.5 0.0 0.027 14.3 0.0 2.3 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein Ras PF00071.22 EFE40197.1 - 0.05 13.2 0.0 0.25 10.9 0.0 2.4 1 1 0 1 1 1 0 Ras family Rhodanese PF00581.20 EFE40198.1 - 2.5e-09 37.6 0.0 5e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain p450 PF00067.22 EFE40199.1 - 6.9e-54 183.3 0.0 1e-53 182.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF3439 PF11921.8 EFE40199.1 - 0.0079 16.2 1.1 0.017 15.0 1.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) ADH_zinc_N_2 PF13602.6 EFE40200.1 - 5.8e-22 79.2 0.0 1e-21 78.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFE40200.1 - 9.3e-16 58.0 0.2 1.4e-15 57.4 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE40200.1 - 0.027 14.3 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain PGM_PMM_II PF02879.16 EFE40200.1 - 0.16 12.6 0.0 0.5 11.0 0.0 1.8 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Glyco_hydro_15 PF00723.21 EFE40201.1 - 1.2e-91 307.7 0.1 1.5e-91 307.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 EFE40201.1 - 5.1e-28 96.8 0.0 1.1e-27 95.7 0.0 1.6 1 0 0 1 1 1 1 Starch binding domain Aha1_N PF09229.11 EFE40202.1 - 1.7e-40 138.4 0.4 3.3e-40 137.5 0.4 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EFE40202.1 - 7.3e-19 68.2 0.1 1.3e-18 67.5 0.1 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Dicty_REP PF05086.12 EFE40202.1 - 2.6 5.9 4.4 3.4 5.5 4.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 EFE40202.1 - 3.4 7.7 21.2 5.7 6.9 21.2 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Rap1_C PF11626.8 EFE40203.1 - 0.11 12.6 0.4 1.9 8.6 0.2 2.5 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain FBPase PF00316.20 EFE40205.1 - 1.2e-68 230.4 0.1 1.5e-68 230.0 0.1 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Shisa PF13908.6 EFE40206.1 - 0.0017 18.6 0.8 0.0027 18.0 0.1 1.6 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator Orf78 PF06024.12 EFE40206.1 - 0.061 13.6 0.8 0.11 12.8 0.8 1.4 1 0 0 1 1 1 0 Orf78 (ac78) OAD_gamma PF04277.13 EFE40206.1 - 0.53 10.9 3.3 2.5 8.7 3.5 2.0 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Fungal_trans_2 PF11951.8 EFE40207.1 - 1.5e-30 106.3 0.5 1.9e-30 106.0 0.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain E1-E2_ATPase PF00122.20 EFE40208.1 - 5.1e-39 133.7 11.0 2.7e-30 105.3 0.0 3.9 3 1 1 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFE40208.1 - 2.1e-21 76.4 6.0 2.1e-21 76.4 6.0 2.6 3 1 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EFE40208.1 - 3.1e-18 65.7 0.0 7.6e-18 64.4 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFE40208.1 - 7e-16 57.7 0.0 1.7e-15 56.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EFE40208.1 - 3.1e-09 37.4 0.0 3.3e-08 34.1 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFE40208.1 - 0.0023 17.7 0.8 0.024 14.4 1.4 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Na_Pi_cotrans PF02690.15 EFE40208.1 - 0.68 10.0 8.1 0.04 14.0 1.8 2.2 2 0 0 2 2 2 0 Na+/Pi-cotransporter HlyIII PF03006.20 EFE40209.1 - 4.5e-29 101.8 14.1 1.7e-27 96.6 14.1 2.0 1 1 0 1 1 1 1 Haemolysin-III related DUF308 PF03729.13 EFE40209.1 - 0.075 13.4 0.4 0.075 13.4 0.4 2.5 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) Sugar_tr PF00083.24 EFE40210.1 - 2.9e-77 260.5 20.1 3.7e-77 260.1 20.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE40210.1 - 1.2e-19 70.5 34.9 1.1e-12 47.5 7.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily V_ATPase_I PF01496.19 EFE40211.1 - 0 1061.0 0.1 0 1060.8 0.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1515 PF07439.11 EFE40211.1 - 0.0016 18.5 0.2 0.0048 16.9 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1515) CheZ PF04344.13 EFE40211.1 - 0.0099 15.8 4.6 0.33 10.8 0.4 2.4 2 0 0 2 2 2 2 Chemotaxis phosphatase, CheZ DUF4988 PF16378.5 EFE40211.1 - 0.12 12.0 0.2 0.29 10.8 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF1664 PF07889.12 EFE40211.1 - 0.22 11.6 3.6 11 6.1 0.1 2.9 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) CdvA PF18822.1 EFE40211.1 - 0.23 11.3 5.1 11 5.8 0.0 3.3 2 1 1 3 3 3 0 CdvA-like coiled-coil domain Tektin PF03148.14 EFE40211.1 - 0.28 9.9 7.4 0.31 9.7 2.2 2.2 2 0 0 2 2 2 0 Tektin family DUF16 PF01519.16 EFE40211.1 - 0.28 11.7 2.5 8.6 6.9 0.0 3.4 3 1 0 3 3 3 0 Protein of unknown function DUF16 Filament PF00038.21 EFE40211.1 - 0.35 10.4 9.3 2.7 7.5 0.1 2.4 2 1 0 2 2 2 0 Intermediate filament protein DUF3552 PF12072.8 EFE40211.1 - 0.66 9.4 4.6 10 5.5 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) BLOC1_2 PF10046.9 EFE40211.1 - 0.66 10.3 4.3 3.3 8.1 1.2 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fmp27_WPPW PF10359.9 EFE40211.1 - 1.7 7.4 4.7 0.68 8.7 1.3 1.8 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DivIC PF04977.15 EFE40211.1 - 1.8 8.4 3.9 2 8.2 0.3 2.9 3 0 0 3 3 3 0 Septum formation initiator FapA PF03961.13 EFE40211.1 - 2.7 6.5 5.6 0.51 8.9 0.6 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A Nup54 PF13874.6 EFE40211.1 - 3.2 7.9 5.2 4.3 7.4 1.3 2.3 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 HMMR_N PF15905.5 EFE40211.1 - 4 6.8 6.2 2.1 7.7 1.8 2.0 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal MOSC PF03473.17 EFE40212.1 - 3.3e-05 23.9 0.0 4.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 MOSC domain BLM10_mid PF16507.5 EFE40213.1 - 1e-209 697.6 0.0 2e-209 696.6 0.0 1.5 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EFE40213.1 - 3.2e-27 94.3 0.0 1.4e-26 92.2 0.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 EFE40213.1 - 7.8e-20 71.0 0.0 2.3e-19 69.5 0.0 1.8 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal CLASP_N PF12348.8 EFE40213.1 - 0.0053 16.3 0.1 3.5 7.1 0.0 3.3 3 0 0 3 3 3 2 CLASP N terminal HEAT_2 PF13646.6 EFE40213.1 - 0.037 14.4 0.1 15 6.0 0.0 3.4 3 0 0 3 3 3 0 HEAT repeats HEAT PF02985.22 EFE40213.1 - 0.043 14.1 0.2 3.8 8.0 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat Mannosyl_trans2 PF04188.13 EFE40214.1 - 7.6e-33 114.5 5.4 8.8e-33 114.3 5.4 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) DBD_Tnp_Hermes PF10683.9 EFE40215.1 - 0.07 12.8 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain EZH2_WD-Binding PF11616.8 EFE40216.1 - 0.036 14.2 1.1 0.046 13.8 0.2 1.6 2 0 0 2 2 2 0 WD repeat binding protein EZH2 Pro_CA PF00484.19 EFE40217.1 - 4.2e-43 147.3 0.1 5.8e-43 146.9 0.1 1.2 1 0 0 1 1 1 1 Carbonic anhydrase MOZ_SAS PF01853.18 EFE40219.1 - 7e-75 250.6 0.0 1.4e-74 249.6 0.0 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EFE40219.1 - 1.9e-21 75.4 3.4 4.5e-21 74.2 3.4 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain zf-Sec23_Sec24 PF04810.15 EFE40219.1 - 0.11 12.6 3.1 0.88 9.7 0.7 2.9 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger PHD_4 PF16866.5 EFE40219.1 - 3.2 7.9 10.9 0.15 12.2 3.0 2.6 1 1 1 2 2 2 0 PHD-finger Acetyltransf_2 PF00797.17 EFE40220.1 - 7.2e-32 111.1 0.0 1.2e-31 110.3 0.0 1.2 1 0 0 1 1 1 1 N-acetyltransferase Thiolase_N PF00108.23 EFE40221.1 - 4.5e-73 245.8 2.1 7.9e-73 245.0 2.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFE40221.1 - 1.5e-43 147.4 0.2 2.7e-43 146.5 0.2 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFE40221.1 - 0.0086 15.7 0.5 0.04 13.5 0.3 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain GFO_IDH_MocA PF01408.22 EFE40222.1 - 8.8e-14 52.4 0.4 2.3e-13 51.0 0.3 1.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold IlvC PF01450.19 EFE40222.1 - 0.11 12.8 0.2 7.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain Drf_GBD PF06371.13 EFE40223.1 - 3.4e-19 69.2 4.6 2.2e-17 63.2 4.6 2.5 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain Snf7 PF03357.21 EFE40224.1 - 2.2e-40 138.1 15.1 2.8e-40 137.7 15.1 1.1 1 0 0 1 1 1 1 Snf7 DUF3584 PF12128.8 EFE40224.1 - 1.3e-05 23.0 4.7 1.5e-05 22.8 4.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) MscS_porin PF12795.7 EFE40224.1 - 0.00051 19.7 4.8 0.26 10.8 2.9 2.2 1 1 1 2 2 2 2 Mechanosensitive ion channel porin domain Atg14 PF10186.9 EFE40224.1 - 0.0043 16.2 3.3 0.0053 15.9 3.3 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4201 PF13870.6 EFE40224.1 - 0.017 14.9 8.1 0.022 14.5 5.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) NPV_P10 PF05531.12 EFE40224.1 - 0.042 14.3 6.2 0.57 10.7 1.9 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Alpha-2-MRAP_C PF06401.11 EFE40224.1 - 0.11 12.5 2.8 0.18 11.7 1.1 2.0 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain ABC_tran_CTD PF16326.5 EFE40224.1 - 0.22 11.8 5.8 0.42 10.9 0.1 3.0 2 1 1 3 3 3 0 ABC transporter C-terminal domain Sec34 PF04136.15 EFE40224.1 - 0.24 11.3 2.4 0.48 10.3 0.2 2.1 2 0 0 2 2 2 0 Sec34-like family FapA PF03961.13 EFE40224.1 - 0.48 9.0 5.9 1.4 7.4 5.2 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A FlaC_arch PF05377.11 EFE40224.1 - 0.53 10.7 5.5 35 4.9 0.9 3.3 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) Muted PF14942.6 EFE40224.1 - 3.4 8.0 8.3 8.4 6.7 4.8 2.3 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein SAPS PF04499.15 EFE40225.1 - 2.8e-172 573.9 6.5 2.8e-172 573.9 6.5 2.9 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein Cauli_DNA-bind PF03310.13 EFE40225.1 - 0.043 13.9 0.4 0.16 12.0 0.4 2.0 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein XPC-binding PF09280.11 EFE40225.1 - 0.15 11.9 0.3 29 4.5 0.0 3.1 3 0 0 3 3 3 0 XPC-binding domain SET PF00856.28 EFE40227.1 - 0.00081 19.8 0.0 0.0017 18.8 0.0 1.5 1 0 0 1 1 1 1 SET domain Complex1_51K PF01512.17 EFE40228.1 - 7.7e-48 162.2 0.0 1.2e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EFE40228.1 - 8.7e-29 99.4 1.7 1.2e-28 99.0 0.2 2.0 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EFE40228.1 - 1e-08 34.9 0.0 3.1e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 SLBB domain Nup96 PF12110.8 EFE40229.1 - 3.2e-78 262.8 0.0 4.9e-78 262.2 0.0 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EFE40229.1 - 3.7e-52 176.4 0.0 7.1e-52 175.5 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EFE40229.1 - 3.8e-13 50.1 80.9 4.4e-11 43.5 41.9 9.6 5 3 5 10 10 10 3 Nucleoporin FG repeat region DUF2336 PF10098.9 EFE40229.1 - 0.023 14.2 0.0 0.058 12.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) F-box-like PF12937.7 EFE40230.1 - 0.00073 19.4 0.3 0.0024 17.8 0.3 1.9 1 0 0 1 1 1 1 F-box-like zf-C3Hc3H PF13891.6 EFE40230.1 - 1.2 9.5 8.0 0.31 11.5 3.6 2.2 2 1 1 3 3 3 0 Potential DNA-binding domain AMP-binding PF00501.28 EFE40231.1 - 1.7e-90 303.6 0.0 2.3e-90 303.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE40231.1 - 5.1e-23 81.8 2.1 4.8e-21 75.5 1.6 3.1 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EFE40231.1 - 7.2e-16 57.9 0.0 1.8e-15 56.5 0.0 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus GET2 PF08690.10 EFE40232.1 - 6.5e-09 35.9 0.0 1.5e-08 34.7 0.0 1.6 1 1 0 1 1 1 1 GET complex subunit GET2 HTH_24 PF13412.6 EFE40232.1 - 0.057 13.0 0.2 0.31 10.6 0.0 2.3 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding C2 PF00168.30 EFE40233.1 - 2.3e-29 101.7 0.0 3.9e-17 62.4 0.0 2.5 2 0 0 2 2 2 2 C2 domain CNH PF00780.22 EFE40236.1 - 1.1e-65 222.0 0.0 1.6e-65 221.4 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 EFE40236.1 - 7.2e-34 117.6 1.4 1.4e-33 116.6 1.4 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 EFE40236.1 - 1.8e-14 54.0 0.0 8.2e-14 51.9 0.0 2.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EFE40236.1 - 0.0034 17.9 0.0 0.013 16.0 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_16 PF17838.1 EFE40236.1 - 0.01 15.7 0.1 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 PH domain RabGAP-TBC PF00566.18 EFE40237.1 - 8.9e-47 159.5 0.0 1.4e-46 158.9 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.6 EFE40237.1 - 1e-06 28.1 2.9 0.01 15.7 0.3 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EFE40237.1 - 1.8e-05 23.9 1.0 0.1 12.2 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFE40237.1 - 0.001 19.5 0.6 0.014 15.8 0.1 2.9 1 1 2 3 3 3 3 EF-hand domain pair GRAM PF02893.20 EFE40237.1 - 0.0021 17.9 0.0 0.0042 17.0 0.0 1.5 1 0 0 1 1 1 1 GRAM domain CRPA PF05745.11 EFE40238.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) HMMR_N PF15905.5 EFE40239.1 - 0.0006 19.4 8.0 0.0006 19.4 8.0 3.0 3 1 0 3 3 3 1 Hyaluronan mediated motility receptor N-terminal Armet PF10208.9 EFE40239.1 - 0.12 12.3 0.5 0.26 11.2 0.5 1.5 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding XkdW PF09636.10 EFE40239.1 - 0.33 11.1 3.6 1.2 9.3 0.2 3.2 3 0 0 3 3 3 0 XkdW protein DUF1319 PF07028.11 EFE40239.1 - 1.6 9.0 4.6 19 5.5 0.9 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Filament PF00038.21 EFE40239.1 - 2 7.9 18.4 33 3.9 18.4 2.4 1 1 0 1 1 1 0 Intermediate filament protein bZIP_1 PF00170.21 EFE40239.1 - 2.4 8.3 7.0 27 5.0 0.4 3.6 2 1 1 3 3 3 0 bZIP transcription factor HAUS5 PF14817.6 EFE40239.1 - 4.1 6.0 25.9 0.98 8.1 6.4 2.6 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 5 Spc7 PF08317.11 EFE40239.1 - 8.2 5.2 19.6 0.76 8.6 9.1 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein adh_short_C2 PF13561.6 EFE40241.1 - 6.1e-36 124.1 6.1 2.2e-35 122.3 6.1 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE40241.1 - 8.1e-29 100.5 2.3 1.3e-28 99.8 2.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE40241.1 - 6.2e-07 29.5 1.6 2.1e-06 27.8 0.5 2.2 2 0 0 2 2 2 1 KR domain DUF1772 PF08592.11 EFE40242.1 - 0.0025 18.1 1.0 0.022 15.1 1.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) DUF1435 PF07256.12 EFE40242.1 - 0.047 13.8 0.1 0.093 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1435) SAP PF02037.27 EFE40243.1 - 3.5e-09 36.2 0.1 6.8e-09 35.3 0.1 1.5 1 0 0 1 1 1 1 SAP domain RSB_motif PF16294.5 EFE40243.1 - 3.4e-07 30.5 0.0 3.4e-07 30.5 0.0 3.8 2 1 0 3 3 3 1 RNSP1-SAP18 binding (RSB) motif SCHIP-1 PF10148.9 EFE40243.1 - 0.22 11.1 4.2 0.47 10.0 4.2 1.4 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 Pinin_SDK_memA PF04696.13 EFE40243.1 - 0.37 10.9 0.0 0.37 10.9 0.0 3.0 2 1 1 3 3 3 0 pinin/SDK/memA/ protein conserved region MitMem_reg PF13012.6 EFE40244.1 - 2.8e-11 43.8 3.1 6.2e-11 42.7 2.3 2.1 2 1 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EFE40244.1 - 7.2e-11 42.1 0.0 1.6e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease KAsynt_C_assoc PF16197.5 EFE40244.1 - 0.0009 19.7 0.0 0.0025 18.3 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Proteasom_PSMB PF10508.9 EFE40245.1 - 0.037 12.5 0.2 0.99 7.8 0.0 2.1 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit RNA_pol_3_Rpc31 PF11705.8 EFE40246.1 - 2e-20 74.1 23.4 2.3e-20 73.8 23.4 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 NPR3 PF03666.13 EFE40246.1 - 0.51 9.1 0.7 0.57 8.9 0.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAD_binding_1 PF00667.20 EFE40248.1 - 1.8e-31 109.4 0.0 2.5e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EFE40248.1 - 2e-13 50.9 0.0 3.2e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFE40248.1 - 0.085 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain ETF PF01012.21 EFE40249.1 - 6.9e-27 94.5 0.0 8.8e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Ysc84 PF04366.12 EFE40250.1 - 3e-46 156.3 0.0 4.8e-46 155.7 0.0 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator CT47 PF15623.6 EFE40250.1 - 0.012 15.5 12.1 0.03 14.2 12.1 1.6 1 0 0 1 1 1 0 Cancer/testis gene family 47 Antimicrobial10 PF08105.11 EFE40250.1 - 0.023 14.8 0.2 1 9.5 0.2 2.5 2 0 0 2 2 2 0 Metchnikowin family PARP PF00644.20 EFE40251.1 - 5.5e-55 186.0 0.0 5.5e-55 186.0 0.0 4.2 3 2 3 6 6 6 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFE40251.1 - 6.1e-43 146.2 0.2 1.2e-42 145.3 0.2 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EFE40251.1 - 1.8e-23 82.4 0.4 1.8e-23 82.4 0.4 2.3 3 0 0 3 3 3 1 WGR domain BRCT PF00533.26 EFE40251.1 - 9.1e-10 38.8 0.0 8.6e-09 35.7 0.0 2.4 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFE40251.1 - 5e-06 26.4 0.1 1e-05 25.4 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EFE40251.1 - 0.00049 20.5 0.0 0.0015 18.9 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Hamartin PF04388.12 EFE40251.1 - 0.63 8.6 16.7 0.88 8.2 16.7 1.2 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 EFE40251.1 - 5.4 4.0 14.2 8.2 3.4 14.2 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Acetyltransf_3 PF13302.7 EFE40252.1 - 9.6e-09 36.0 0.0 1.3e-08 35.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE40252.1 - 0.0015 18.7 0.0 0.027 14.7 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Peptidase_S10 PF00450.22 EFE40253.1 - 2e-84 284.5 2.9 3.8e-84 283.5 2.9 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase Pkinase_Tyr PF07714.17 EFE40254.1 - 7e-23 81.2 0.0 1.3e-22 80.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFE40254.1 - 1e-20 74.2 0.0 2.1e-20 73.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 EFE40254.1 - 0.029 14.0 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 EFE40254.1 - 0.038 13.3 0.0 0.15 11.4 0.0 1.8 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 EFE40254.1 - 0.071 12.4 0.1 0.16 11.3 0.1 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE40254.1 - 0.15 11.9 0.3 10 5.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE40254.1 - 0.17 10.6 0.0 0.24 10.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase DUF5353 PF17304.2 EFE40255.1 - 1.4e-27 95.2 2.7 2.4e-27 94.5 2.7 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5353) Rotamase PF00639.21 EFE40255.1 - 0.0095 16.9 4.9 0.0095 16.9 4.9 2.1 1 1 1 2 2 2 1 PPIC-type PPIASE domain Presenilin PF01080.17 EFE40255.1 - 0.18 10.5 0.7 0.17 10.6 0.7 1.1 1 0 0 1 1 1 0 Presenilin Borrelia_P83 PF05262.11 EFE40255.1 - 0.27 9.7 13.9 0.33 9.4 13.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein PPV_E1_N PF00524.18 EFE40255.1 - 0.28 11.6 7.5 0.49 10.8 7.5 1.4 1 1 0 1 1 1 0 E1 Protein, N terminal domain DUF883 PF05957.13 EFE40255.1 - 0.69 10.5 8.5 0.23 12.1 3.6 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ax_dynein_light PF10211.9 EFE40255.1 - 0.74 9.7 10.2 0.045 13.7 4.5 1.7 2 0 0 2 2 2 0 Axonemal dynein light chain Spc7 PF08317.11 EFE40255.1 - 1.3 7.9 10.5 1.5 7.6 10.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Menin PF05053.13 EFE40255.1 - 1.6 7.0 7.4 2.3 6.5 7.4 1.1 1 0 0 1 1 1 0 Menin 2-oxoacid_dh PF00198.23 EFE40256.1 - 2e-74 250.0 0.0 2.6e-74 249.6 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFE40256.1 - 4.4e-17 61.7 0.3 4.4e-17 61.7 0.3 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 EFE40256.1 - 1.5e-15 57.2 1.2 3.5e-15 56.0 0.4 2.1 2 0 0 2 2 2 1 e3 binding domain SopE_GEF PF07487.13 EFE40256.1 - 0.05 13.7 0.0 0.097 12.8 0.0 1.4 1 0 0 1 1 1 0 SopE GEF domain Biotin_lipoyl_2 PF13533.6 EFE40256.1 - 0.12 12.2 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 Biotin-lipoyl like Sec7 PF01369.20 EFE40257.1 - 4.8e-69 231.7 0.2 1.3e-68 230.2 0.2 1.8 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EFE40257.1 - 1.4e-40 138.8 6.2 1.4e-40 138.8 6.2 2.9 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EFE40257.1 - 4.7e-34 116.1 9.9 1.9e-32 110.9 0.1 6.2 7 0 0 7 7 7 1 Domain of unknown function (DUF1981) DCB PF16213.5 EFE40257.1 - 7.2e-19 68.1 3.4 4.5e-17 62.3 0.2 3.6 3 0 0 3 3 3 2 Dimerisation and cyclophilin-binding domain of Mon2 NAD_binding_7 PF13241.6 EFE40258.1 - 1.8e-31 108.7 0.2 2.8e-31 108.1 0.2 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EFE40258.1 - 1.2e-29 101.8 0.0 1.8e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EFE40258.1 - 6e-15 54.4 0.1 1.2e-14 53.5 0.1 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.20 EFE40258.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_3 PF13738.6 EFE40258.1 - 0.039 13.2 0.1 0.057 12.7 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 EFE40258.1 - 0.18 11.1 1.9 0.31 10.4 0.2 1.9 1 1 1 2 2 2 0 ThiF family Pribosyltran_N PF13793.6 EFE40259.1 - 9.3e-37 125.5 0.1 7.6e-35 119.4 0.0 2.4 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFE40259.1 - 2.4e-33 115.7 0.0 1.1e-28 100.6 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFE40259.1 - 2.9e-11 43.1 0.0 2.5e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 Phosphoribosyl transferase domain CbiJ PF02571.14 EFE40259.1 - 0.1 12.1 0.1 0.36 10.3 0.0 2.0 2 1 0 2 2 2 0 Precorrin-6x reductase CbiJ/CobK DUF719 PF05334.13 EFE40260.1 - 0.02 15.1 3.3 1.4 9.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF719) DUF3899 PF13038.6 EFE40260.1 - 0.032 14.7 1.3 0.039 14.5 0.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) NPR3 PF03666.13 EFE40260.1 - 0.45 9.2 3.7 0.49 9.1 3.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ferlin_C PF16165.5 EFE40260.1 - 5.6 6.9 7.1 5.5 6.9 2.5 2.0 2 0 0 2 2 2 0 Ferlin C-terminus Peptidase_S49_N PF08496.10 EFE40260.1 - 8.4 6.4 7.8 2 8.5 1.6 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Isochorismatase PF00857.20 EFE40261.1 - 1.4e-20 74.2 0.0 1.7e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Methyltransf_10 PF05971.12 EFE40262.1 - 3.1e-26 92.4 0.1 4.1e-26 92.0 0.1 1.2 1 0 0 1 1 1 1 RNA methyltransferase Complex1_LYR PF05347.15 EFE40263.1 - 5.2e-05 23.2 0.9 0.00012 22.0 0.9 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFE40263.1 - 0.071 13.9 3.3 0.099 13.4 2.1 1.9 2 0 0 2 2 2 0 Complex1_LYR-like Ank_4 PF13637.6 EFE40264.1 - 3.2e-10 40.3 1.3 3e-08 34.0 0.2 3.2 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFE40264.1 - 2.3e-06 28.1 0.1 0.014 16.0 0.4 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFE40264.1 - 3.9e-05 23.9 2.2 0.0028 17.9 0.3 3.7 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE40264.1 - 0.00062 20.0 2.5 0.049 14.2 0.2 4.0 4 1 0 4 4 4 1 Ankyrin repeat KilA-N PF04383.13 EFE40264.1 - 0.0044 16.9 0.2 0.0044 16.9 0.2 2.8 2 1 0 2 2 2 1 KilA-N domain FapA PF03961.13 EFE40264.1 - 0.62 8.6 6.6 1.2 7.7 6.6 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Ank PF00023.30 EFE40264.1 - 1.1 9.9 7.0 4.7 7.8 0.4 3.8 3 0 0 3 3 3 0 Ankyrin repeat DivIC PF04977.15 EFE40264.1 - 2.3 8.1 6.6 42 4.0 4.2 3.0 2 0 0 2 2 2 0 Septum formation initiator ApoLp-III PF07464.11 EFE40264.1 - 4.6 7.3 16.1 1.1 9.4 7.5 2.7 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Exonuc_VII_L PF02601.15 EFE40264.1 - 9.6 5.7 16.4 0.97 8.9 7.5 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit TraT PF05818.12 EFE40265.1 - 0.0018 18.0 2.3 0.0041 16.8 2.3 1.7 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein Rick_17kDa_Anti PF05433.15 EFE40265.1 - 0.002 17.9 24.0 0.0077 16.1 24.1 2.0 1 1 0 1 1 1 1 Glycine zipper 2TM domain DUF755 PF05501.11 EFE40265.1 - 0.032 14.5 19.8 0.058 13.7 19.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Med19 PF10278.9 EFE40265.1 - 0.65 9.9 12.5 1 9.2 12.5 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 TFIIF_alpha PF05793.12 EFE40265.1 - 1.2 7.6 16.5 1.6 7.2 16.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Gly-zipper_Omp PF13488.6 EFE40265.1 - 1.8 8.7 24.0 3 7.9 23.0 2.0 1 1 0 1 1 1 0 Glycine zipper AP3D1 PF06375.11 EFE40265.1 - 2.4 8.4 15.5 3.8 7.7 15.5 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF1275 PF06912.11 EFE40266.1 - 2.4e-37 128.7 17.3 2.3e-36 125.5 17.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1275) TPR_1 PF00515.28 EFE40267.1 - 9.3e-05 22.1 3.1 0.018 14.8 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE40267.1 - 0.0016 18.0 0.0 0.006 16.2 0.0 2.1 1 0 0 1 1 1 1 TPR repeat TPR_7 PF13176.6 EFE40267.1 - 0.0048 16.8 3.5 0.35 11.0 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFE40267.1 - 0.011 16.3 6.0 10 6.7 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFE40267.1 - 0.025 14.7 0.0 0.025 14.7 0.0 5.2 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFE40267.1 - 0.065 13.6 0.1 3.9 8.1 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFE40267.1 - 0.15 12.7 0.0 0.15 12.7 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFE40267.1 - 4 7.7 11.1 2.3 8.5 0.2 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ABC_tran PF00005.27 EFE40268.1 - 3.3e-47 160.4 0.1 4.3e-23 82.3 0.0 3.7 2 2 0 2 2 2 2 ABC transporter 4HB PF17947.1 EFE40268.1 - 4.2e-30 103.6 1.0 1.7e-29 101.7 1.0 2.2 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 EFE40268.1 - 2.9e-17 63.4 0.8 0.0019 18.1 0.1 5.0 4 1 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFE40268.1 - 1.8e-16 60.2 0.0 1.5e-06 27.8 0.0 3.6 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFE40268.1 - 1.6e-09 38.5 3.7 0.00018 22.1 0.2 3.0 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EFE40268.1 - 9.4e-09 34.9 0.1 0.0043 16.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFE40268.1 - 3.3e-08 33.6 0.0 0.00015 21.7 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 EFE40268.1 - 1e-06 29.1 0.0 0.017 15.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFE40268.1 - 1.2e-06 29.1 2.4 0.29 11.5 0.0 4.6 5 0 0 5 5 4 2 AAA ATPase domain MMR_HSR1 PF01926.23 EFE40268.1 - 1.2e-06 28.6 0.0 0.006 16.7 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA PF00004.29 EFE40268.1 - 2.6e-06 27.9 0.3 0.2 12.1 0.0 5.0 6 0 0 6 6 4 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFE40268.1 - 7.4e-06 26.5 0.1 0.15 12.6 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFE40268.1 - 8.5e-06 26.1 0.0 0.13 12.6 0.0 3.5 3 0 0 3 3 2 2 AAA domain PduV-EutP PF10662.9 EFE40268.1 - 4.8e-05 23.1 0.0 0.071 12.8 0.0 2.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.17 EFE40268.1 - 5.1e-05 23.5 0.1 0.26 11.3 0.0 3.3 2 0 0 2 2 2 2 Helicase HerA, central domain MeaB PF03308.16 EFE40268.1 - 5.8e-05 22.2 0.1 0.19 10.7 0.1 2.6 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 EFE40268.1 - 0.00011 22.1 0.1 0.79 9.4 0.0 3.5 3 1 1 4 4 4 2 AAA ATPase domain Dynamin_N PF00350.23 EFE40268.1 - 0.00012 22.2 0.0 0.0065 16.5 0.0 2.7 2 0 0 2 2 2 1 Dynamin family NACHT PF05729.12 EFE40268.1 - 0.00012 22.0 0.0 0.09 12.7 0.0 2.7 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EFE40268.1 - 0.00018 21.8 0.0 0.8 10.1 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.6 EFE40268.1 - 0.00027 21.1 0.0 0.59 10.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_27 PF13514.6 EFE40268.1 - 0.00033 20.3 0.0 0.22 11.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFE40268.1 - 0.00073 19.3 0.0 1.2 8.8 0.0 2.9 3 0 0 3 3 3 1 AAA domain G-alpha PF00503.20 EFE40268.1 - 0.0014 17.9 0.0 1.8 7.6 0.0 3.0 3 0 0 3 3 3 1 G-protein alpha subunit AAA_14 PF13173.6 EFE40268.1 - 0.0014 18.6 0.0 3.6 7.6 0.0 3.2 3 1 0 3 3 2 0 AAA domain AAA_30 PF13604.6 EFE40268.1 - 0.0016 18.2 0.0 2.5 7.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EFE40268.1 - 0.002 17.4 0.9 0.1 11.8 0.0 2.9 3 0 0 3 3 3 1 NB-ARC domain SbcCD_C PF13558.6 EFE40268.1 - 0.0027 17.9 0.0 1.5 9.1 0.0 3.3 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Roc PF08477.13 EFE40268.1 - 0.0065 16.7 0.0 3.8 7.7 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EFE40268.1 - 0.0073 16.1 0.0 4.1 7.1 0.0 2.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein cobW PF02492.19 EFE40268.1 - 0.012 15.2 0.1 9.1 5.8 0.0 3.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MukB PF04310.12 EFE40268.1 - 0.014 15.2 0.1 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal Rad17 PF03215.15 EFE40268.1 - 0.017 15.1 0.0 1.4 8.8 0.0 2.8 3 0 0 3 3 2 0 Rad17 P-loop domain CLP1_P PF16575.5 EFE40268.1 - 0.019 14.8 0.0 1.5 8.6 0.0 2.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ATPase_2 PF01637.18 EFE40268.1 - 0.022 14.7 0.0 2.7 7.8 0.0 3.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Cytidylate_kin PF02224.18 EFE40268.1 - 0.025 14.3 0.0 4 7.1 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase IstB_IS21 PF01695.17 EFE40268.1 - 0.026 14.3 0.0 14 5.4 0.0 3.0 2 0 0 2 2 2 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 EFE40268.1 - 0.028 14.1 0.0 11 5.6 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 EFE40268.1 - 0.029 13.9 0.0 4.5 6.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Ploopntkinase3 PF18751.1 EFE40268.1 - 0.04 13.8 0.0 6.7 6.6 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Mg_chelatase PF01078.21 EFE40268.1 - 0.04 13.3 0.4 3.3 7.0 0.0 3.2 4 0 0 4 4 3 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFE40268.1 - 0.044 13.8 0.0 17 5.4 0.0 3.2 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EFE40268.1 - 0.075 12.6 0.0 5 6.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_PrkA PF08298.11 EFE40268.1 - 0.078 11.9 0.0 34 3.2 0.0 3.1 3 0 0 3 3 3 0 PrkA AAA domain DUF815 PF05673.13 EFE40268.1 - 0.087 12.0 0.0 12 5.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) CAP_N PF01213.19 EFE40268.1 - 0.14 11.6 7.4 0.35 10.3 7.4 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HEAT PF02985.22 EFE40268.1 - 0.18 12.2 0.2 23 5.6 0.0 3.6 3 0 0 3 3 2 0 HEAT repeat DUF3437 PF11919.8 EFE40268.1 - 0.18 11.7 0.3 1.4 8.9 0.1 2.7 2 1 1 3 3 1 0 Domain of unknown function (DUF3437) Septin PF00735.18 EFE40268.1 - 0.23 10.7 2.1 3.7 6.7 0.0 3.1 4 0 0 4 4 4 0 Septin Mu-like_Pro PF10123.9 EFE40268.1 - 0.23 11.0 9.3 0.7 9.4 9.3 1.9 1 0 0 1 1 1 0 Mu-like prophage I protein HEAT_EZ PF13513.6 EFE40268.1 - 0.39 11.3 5.1 16 6.1 0.0 4.8 4 1 2 6 6 4 0 HEAT-like repeat AAA_13 PF13166.6 EFE40268.1 - 2.4 6.7 8.3 3.1 6.3 0.0 3.3 5 0 0 5 5 3 0 AAA domain IMS PF00817.20 EFE40269.1 - 1.7e-38 131.9 0.0 2.9e-38 131.2 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EFE40269.1 - 1.2e-16 61.5 0.1 1.3e-15 58.2 0.2 2.2 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain Reprolysin_5 PF13688.6 EFE40271.1 - 1.2e-57 195.2 5.6 1.2e-57 195.2 5.6 2.3 2 1 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EFE40271.1 - 1.2e-45 155.8 1.1 2.8e-45 154.6 1.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EFE40271.1 - 6.5e-44 150.0 1.2 1.2e-43 149.1 1.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 EFE40271.1 - 5.7e-15 55.9 35.7 5.7e-15 55.9 35.7 4.4 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 EFE40271.1 - 2.9e-11 44.0 0.1 8.5e-11 42.4 0.1 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR_2 PF17771.1 EFE40271.1 - 2.2e-07 31.3 4.1 2.2e-07 31.3 4.1 5.4 2 1 2 5 5 5 1 ADAM cysteine-rich domain EF-hand_7 PF13499.6 EFE40272.1 - 3.2e-16 59.5 0.6 5.3e-10 39.6 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFE40272.1 - 1.3e-14 52.5 1.5 1.8e-05 23.9 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EFE40272.1 - 1.8e-13 49.2 3.4 1.8e-05 24.3 0.2 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EFE40272.1 - 1.9e-11 43.6 1.3 1.3e-08 34.6 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 EFE40272.1 - 0.0063 16.5 0.0 0.021 14.7 0.0 1.7 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF3572 PF12096.8 EFE40272.1 - 0.024 14.8 0.1 1 9.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3572) EF-hand_5 PF13202.6 EFE40272.1 - 0.034 13.6 4.2 1.4 8.5 0.1 2.7 3 0 0 3 3 3 0 EF hand EFhand_Ca_insen PF08726.10 EFE40272.1 - 0.16 12.1 0.3 0.55 10.4 0.0 2.0 2 1 1 3 3 3 0 Ca2+ insensitive EF hand MgsA_C PF12002.8 EFE40273.1 - 7.8e-59 198.4 0.1 1.3e-58 197.6 0.1 1.3 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EFE40273.1 - 3e-24 85.1 0.6 6.6e-24 84.1 0.6 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EFE40273.1 - 5.1e-14 52.8 0.0 1.2e-13 51.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFE40273.1 - 2.3e-11 43.7 0.0 4.5e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EFE40273.1 - 9.4e-06 25.1 0.2 0.044 13.1 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFE40273.1 - 4.2e-05 23.6 0.0 0.0012 18.8 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EFE40273.1 - 7e-05 22.6 0.0 0.0037 17.0 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 EFE40273.1 - 0.0001 22.8 0.3 0.038 14.4 0.1 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_3 PF07726.11 EFE40273.1 - 0.00031 20.6 0.0 0.00091 19.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFE40273.1 - 0.00091 19.5 0.1 0.0039 17.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EFE40273.1 - 0.0014 17.8 0.0 0.0022 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EFE40273.1 - 0.0021 18.1 0.0 0.004 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EFE40273.1 - 0.0059 16.6 0.1 0.52 10.3 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit TsaE PF02367.17 EFE40273.1 - 0.018 15.0 0.0 0.036 14.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EFE40273.1 - 0.026 14.2 0.2 0.084 12.6 0.2 1.9 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 EFE40273.1 - 0.027 13.7 0.0 0.042 13.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 EFE40273.1 - 0.035 14.2 0.0 0.076 13.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain PIF1 PF05970.14 EFE40273.1 - 0.036 13.2 0.0 0.072 12.2 0.0 1.4 1 0 0 1 1 1 0 PIF1-like helicase NACHT PF05729.12 EFE40273.1 - 0.063 13.2 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 EFE40273.1 - 0.076 12.8 0.1 5.1 6.9 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EFE40273.1 - 0.094 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EFE40273.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EFE40273.1 - 0.11 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 EFE40273.1 - 0.12 12.9 0.0 0.24 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EFE40273.1 - 0.15 12.0 0.0 10 6.0 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EFE40273.1 - 0.16 12.3 0.2 0.55 10.6 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_13 PF13166.6 EFE40273.1 - 0.19 10.3 0.1 0.39 9.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain Aminotran_1_2 PF00155.21 EFE40274.1 - 1.2e-53 182.6 0.0 1.4e-53 182.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EFE40274.1 - 0.0064 15.8 0.0 0.0092 15.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase KH_1 PF00013.29 EFE40275.1 - 2.1e-46 155.6 7.9 1.5e-15 56.7 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EFE40275.1 - 6.7e-13 48.3 1.8 0.00068 19.4 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EFE40275.1 - 3.8e-09 36.3 3.8 0.033 14.0 0.1 3.8 3 1 0 3 3 3 3 KH domain KH_5 PF13184.6 EFE40275.1 - 0.0059 16.7 3.2 7 6.8 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain TFIIA PF03153.13 EFE40275.1 - 1.7 8.6 20.6 3.9 7.4 20.6 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Amidoligase_2 PF12224.8 EFE40276.1 - 1.1e-05 25.3 0.0 0.00043 20.0 0.0 2.5 2 1 0 2 2 2 2 Putative amidoligase enzyme DUF3665 PF12427.8 EFE40277.1 - 2e-05 24.1 0.3 0.076 12.7 0.0 2.4 2 0 0 2 2 2 2 Branched-chain amino acid aminotransferase Ald_Xan_dh_C2 PF02738.18 EFE40279.1 - 8.3e-186 618.7 0.7 1.2e-185 618.2 0.7 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase CO_deh_flav_C PF03450.17 EFE40279.1 - 3e-34 117.3 0.0 1.3e-33 115.2 0.0 2.2 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain FAD_binding_5 PF00941.21 EFE40279.1 - 2.6e-29 102.2 0.0 8.5e-17 61.4 0.0 2.5 1 1 1 2 2 2 2 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 EFE40279.1 - 3.2e-29 101.5 0.0 7.4e-29 100.3 0.0 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 EFE40279.1 - 2.6e-28 97.9 0.0 7e-28 96.5 0.0 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 EFE40279.1 - 5e-09 36.0 0.4 1.5e-08 34.4 0.1 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Sigma70_r3 PF04539.16 EFE40279.1 - 0.09 12.9 0.0 1.3 9.2 0.0 2.8 3 0 0 3 3 3 0 Sigma-70 region 3 AMP-binding PF00501.28 EFE40280.1 - 6.1e-70 235.9 0.0 9e-70 235.4 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFE40280.1 - 3.6e-57 193.5 0.0 2.9e-52 177.4 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein Condensation PF00668.20 EFE40280.1 - 2.4e-09 36.4 0.2 1.7e-08 33.6 0.2 2.1 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EFE40280.1 - 3.3e-09 37.0 0.0 7.8e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EFE40280.1 - 2.1e-06 27.4 0.0 5.1e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 EFE40280.1 - 0.001 20.0 0.0 0.0037 18.2 0.0 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 EFE40280.1 - 0.004 16.2 0.0 0.011 14.7 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFE40280.1 - 0.019 14.4 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase PRK PF00485.18 EFE40281.1 - 0.00017 21.4 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.27 EFE40281.1 - 0.00025 21.6 0.0 0.00039 20.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EFE40281.1 - 0.0034 17.8 0.1 0.0061 17.0 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFE40281.1 - 0.02 15.4 0.1 0.053 14.1 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFE40281.1 - 0.043 14.0 0.6 0.13 12.5 0.2 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFE40281.1 - 0.16 11.7 0.1 0.32 10.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SNF2_N PF00176.23 EFE40282.1 - 1.3e-37 129.3 0.0 3.9e-33 114.6 0.0 2.5 3 0 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE40282.1 - 8.4e-08 32.5 0.0 2.8e-07 30.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HMG_box PF00505.19 EFE40283.1 - 4.5e-18 65.4 0.0 8.5e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFE40283.1 - 0.0058 17.2 0.0 0.015 15.9 0.0 1.6 1 0 0 1 1 1 1 HMG-box domain Ribosomal_S6e PF01092.19 EFE40284.1 - 9.2e-46 154.9 0.0 2.5e-45 153.5 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein S6e Pribosyl_synth PF14572.6 EFE40285.1 - 5.7e-44 150.3 1.0 4.7e-37 127.8 0.4 2.5 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EFE40285.1 - 2.5e-43 146.7 0.8 1.4e-40 137.8 0.2 2.9 2 1 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EFE40285.1 - 1e-18 67.4 0.6 9.7e-18 64.2 0.3 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFE40285.1 - 0.002 17.6 0.1 0.0041 16.6 0.1 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF913 PF06025.12 EFE40286.1 - 3.6e-127 424.3 0.0 3.6e-127 424.3 0.0 6.3 6 2 0 6 6 6 2 Domain of Unknown Function (DUF913) DUF908 PF06012.12 EFE40286.1 - 2e-111 372.9 5.4 2e-111 372.9 5.4 4.4 5 0 0 5 5 5 1 Domain of Unknown Function (DUF908) HECT PF00632.25 EFE40286.1 - 1.1e-93 314.1 0.0 1.9e-93 313.3 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 EFE40286.1 - 5.1e-30 102.0 21.6 4.6e-10 38.6 3.2 4.4 3 0 0 3 3 3 3 Ubiquitin binding region UBA PF00627.31 EFE40286.1 - 0.00075 19.4 0.0 0.0025 17.7 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain An_peroxidase PF03098.15 EFE40287.1 - 1.7e-28 99.5 0.0 2.6e-20 72.5 0.0 2.7 2 1 1 3 3 3 2 Animal haem peroxidase Steroid_dh PF02544.16 EFE40288.1 - 1.1e-31 109.9 0.3 1.4e-31 109.5 0.3 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EFE40288.1 - 2.3e-06 27.3 0.3 2.9e-06 27.0 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EFE40288.1 - 4.1e-05 23.9 0.3 9.1e-05 22.8 0.3 1.6 1 0 0 1 1 1 1 Phospholipid methyltransferase Glyco_transf_34 PF05637.12 EFE40289.1 - 6.7e-58 196.2 0.0 8.2e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Ribosomal_L28 PF00830.19 EFE40290.1 - 1.4e-15 57.2 0.6 1.4e-15 57.2 0.6 2.2 3 0 0 3 3 3 1 Ribosomal L28 family TIP49 PF06068.13 EFE40291.1 - 7.5e-145 482.5 0.1 8.8e-145 482.3 0.1 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EFE40291.1 - 4.9e-21 74.6 0.1 2.6e-20 72.3 0.0 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EFE40291.1 - 1.3e-11 45.1 0.3 2.1e-07 31.4 0.1 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFE40291.1 - 2.4e-06 27.4 0.3 0.0079 16.0 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFE40291.1 - 6.9e-06 26.4 0.1 0.036 14.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EFE40291.1 - 0.00016 22.1 0.1 0.12 12.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFE40291.1 - 0.00026 21.4 0.2 0.0053 17.2 0.2 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EFE40291.1 - 0.00027 21.2 0.2 0.00082 19.6 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFE40291.1 - 0.00059 19.8 0.2 0.19 11.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 EFE40291.1 - 0.0026 18.2 0.2 0.049 14.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EFE40291.1 - 0.0047 16.6 0.0 3.5 7.3 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Zeta_toxin PF06414.12 EFE40291.1 - 0.0052 16.1 0.2 0.016 14.5 0.1 1.8 2 0 0 2 2 2 1 Zeta toxin DnaB_C PF03796.15 EFE40291.1 - 0.0081 15.5 0.1 0.024 14.0 0.0 1.8 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain ATPase PF06745.13 EFE40291.1 - 0.015 14.7 0.5 0.14 11.5 0.0 2.4 3 0 0 3 3 3 0 KaiC AAA_25 PF13481.6 EFE40291.1 - 0.015 14.9 0.1 0.029 14.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFE40291.1 - 0.016 14.6 0.1 0.82 9.0 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EFE40291.1 - 0.021 14.9 0.0 0.52 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFE40291.1 - 0.037 14.6 0.0 0.23 12.0 0.0 2.3 2 1 1 3 3 3 0 AAA domain TetR_C_30 PF17939.1 EFE40291.1 - 0.038 14.2 0.0 0.083 13.1 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF2075 PF09848.9 EFE40291.1 - 0.054 12.7 0.0 0.094 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EFE40291.1 - 0.057 13.2 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 EFE40291.1 - 0.089 12.3 0.1 0.42 10.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EFE40291.1 - 0.13 12.0 0.3 2 8.1 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFE40291.1 - 0.17 12.1 0.0 0.48 10.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 EFE40291.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain V-SNARE PF05008.15 EFE40292.1 - 4.6e-23 81.4 7.2 4.6e-23 81.4 7.2 1.9 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EFE40292.1 - 3e-15 56.3 2.0 3e-15 56.3 2.0 2.9 3 1 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus DUF1542 PF07564.11 EFE40292.1 - 0.12 12.5 6.5 0.16 12.1 4.2 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) CDPS PF16715.5 EFE40292.1 - 0.16 11.6 2.0 0.17 11.5 1.6 1.3 1 1 0 1 1 1 0 Cyclodipeptide synthase DUF4355 PF14265.6 EFE40292.1 - 0.7 10.1 8.3 0.16 12.2 4.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Exonuc_VII_L PF02601.15 EFE40292.1 - 0.93 9.0 12.4 1.4 8.4 12.4 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit TBCA PF02970.16 EFE40292.1 - 1.1 9.6 8.2 0.57 10.6 2.6 2.7 2 1 0 2 2 2 0 Tubulin binding cofactor A zf-C4H2 PF10146.9 EFE40292.1 - 1.1 9.5 9.6 7.4 6.8 9.9 2.0 1 1 0 1 1 1 0 Zinc finger-containing protein DUF349 PF03993.12 EFE40292.1 - 2 8.8 11.1 3.3 8.1 0.3 2.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) FUSC PF04632.12 EFE40292.1 - 2 6.8 9.4 0.16 10.4 3.2 1.6 1 1 0 1 1 1 0 Fusaric acid resistance protein family V_ATPase_I PF01496.19 EFE40292.1 - 8.8 4.1 6.7 2.5 5.9 2.6 1.8 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF2407_C PF13373.6 EFE40293.1 - 8.5e-43 145.9 0.1 1.3e-42 145.3 0.1 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EFE40293.1 - 5e-39 133.1 0.0 7.6e-39 132.5 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EFE40293.1 - 0.018 14.8 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family Rad60-SLD_2 PF13881.6 EFE40293.1 - 0.041 14.0 0.0 0.073 13.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Fe-S_biosyn PF01521.20 EFE40294.1 - 1.6e-17 63.7 0.0 6.9e-17 61.6 0.0 2.0 3 0 0 3 3 3 1 Iron-sulphur cluster biosynthesis 2OG-Fe_Oxy_2 PF10014.9 EFE40295.1 - 9.9e-55 185.3 0.1 1.2e-54 185.0 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe dioxygenase MFS_1 PF07690.16 EFE40296.1 - 2.2e-30 105.8 43.6 2.2e-30 105.8 43.6 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE40296.1 - 9.1e-13 47.9 12.4 9.1e-13 47.9 12.4 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EFE40296.1 - 1.2e-05 24.8 5.7 1.2e-05 24.8 5.7 2.4 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB DUF1741 PF08427.10 EFE40297.1 - 2.1e-84 282.8 0.5 4.3e-84 281.8 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) MRG PF05712.13 EFE40298.1 - 1.6e-53 180.9 0.0 2.4e-53 180.4 0.0 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 EFE40298.1 - 8e-08 32.1 2.2 1.9e-07 30.8 2.2 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Cnl2_NKP2 PF09447.10 EFE40299.1 - 7.2e-28 96.5 1.7 1.2e-27 95.8 1.7 1.4 1 0 0 1 1 1 1 Cnl2/NKP2 family protein APG6_N PF17675.1 EFE40299.1 - 0.028 15.0 1.3 0.13 12.8 1.3 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region ATG16 PF08614.11 EFE40299.1 - 0.037 14.3 1.0 0.045 14.0 1.0 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Mod_r PF07200.13 EFE40299.1 - 0.23 11.5 2.6 0.93 9.6 2.6 1.8 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Ctf8 PF09696.10 EFE40301.1 - 8.9e-48 162.2 0.0 1e-47 162.0 0.0 1.0 1 0 0 1 1 1 1 Ctf8 Sox17_18_mid PF12067.8 EFE40301.1 - 0.057 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Sox 17/18 central domain Glyoxalase PF00903.25 EFE40302.1 - 4.3e-15 56.0 0.0 2.9e-13 50.1 0.0 2.6 2 2 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFE40302.1 - 3.1e-08 33.9 0.0 4.4e-05 23.7 0.0 3.0 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EFE40302.1 - 4.1e-05 23.8 0.0 0.61 10.2 0.0 3.4 2 2 1 3 3 3 2 Glyoxalase-like domain Pectinesterase PF01095.19 EFE40302.1 - 0.12 11.0 0.0 0.19 10.4 0.0 1.3 1 0 0 1 1 1 0 Pectinesterase RabGAP-TBC PF00566.18 EFE40303.1 - 3e-49 167.6 0.3 3e-49 167.6 0.3 2.7 2 2 1 4 4 4 1 Rab-GTPase-TBC domain PPTA PF01239.22 EFE40304.1 - 6.4e-36 121.1 3.1 1.7e-08 33.9 0.9 4.6 4 0 0 4 4 4 4 Protein prenyltransferase alpha subunit repeat APH PF01636.23 EFE40305.1 - 8e-16 58.7 0.1 1.1e-15 58.2 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE40305.1 - 1.6e-05 24.6 0.0 2.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EFE40305.1 - 0.0022 17.4 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain DUF1679 PF07914.11 EFE40305.1 - 0.0033 16.3 0.3 0.48 9.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.14 EFE40305.1 - 0.029 13.6 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase Pkinase_Tyr PF07714.17 EFE40305.1 - 0.13 11.5 0.0 0.97 8.7 0.0 2.0 1 1 0 1 1 1 0 Protein tyrosine kinase Glyco_hydro_56 PF01630.18 EFE40305.1 - 0.14 11.2 0.8 9.9 5.1 0.0 2.6 2 1 1 3 3 3 0 Hyaluronidase Kdo PF06293.14 EFE40305.1 - 0.18 11.1 0.3 0.96 8.8 0.2 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 EFE40306.1 - 3.4e-10 40.3 2.7 6.3e-06 26.8 0.0 5.1 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE40306.1 - 1.6e-08 34.7 0.2 0.00019 21.7 0.1 3.8 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain QueH PF02677.14 EFE40306.1 - 0.19 11.8 0.0 0.32 11.1 0.0 1.3 1 0 0 1 1 1 0 Epoxyqueuosine reductase QueH Utp12 PF04003.12 EFE40307.1 - 1.3e-22 80.2 0.6 5.6e-22 78.1 0.5 2.1 2 0 0 2 2 2 1 Dip2/Utp12 Family DUF212 PF02681.14 EFE40307.1 - 0.12 12.5 1.1 0.28 11.3 1.1 1.5 1 0 0 1 1 1 0 Divergent PAP2 family Bromodomain PF00439.25 EFE40308.1 - 1.6e-38 130.6 1.1 1.7e-20 72.8 0.4 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 EFE40308.1 - 2.8e-18 65.8 0.2 7.5e-18 64.5 0.2 1.8 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DUF3573 PF12097.8 EFE40308.1 - 0.33 9.7 2.3 0.72 8.6 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Frataxin_Cyay PF01491.16 EFE40309.1 - 1e-33 115.7 0.0 1.4e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Frataxin-like domain DUF1192 PF06698.11 EFE40309.1 - 0.097 12.7 0.5 0.2 11.8 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) AKAP7_NLS PF10469.9 EFE40310.1 - 2.4e-15 57.0 0.0 4.2e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Sec6 PF06046.13 EFE40311.1 - 1e-173 578.9 3.8 1.3e-173 578.4 3.8 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 Ribosomal_L30 PF00327.20 EFE40312.1 - 3.6e-12 46.0 0.2 5e-12 45.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Pyridoxal_deC PF00282.19 EFE40313.1 - 3.8e-13 48.9 0.0 7.3e-13 48.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.17 EFE40313.1 - 8.3e-07 28.6 0.0 1.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EFE40313.1 - 1.5e-06 27.4 0.0 1.6e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFE40313.1 - 0.0033 16.6 0.0 0.0076 15.5 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFE40313.1 - 0.12 10.9 0.0 0.2 10.1 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EFE40314.1 - 3.3e-85 286.4 0.0 4.1e-85 286.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II fn3_4 PF16794.5 EFE40314.1 - 0.15 12.0 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 Fibronectin-III type domain DUF1604 PF07713.13 EFE40316.1 - 2.1e-42 142.8 9.7 3.7e-42 142.0 2.2 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EFE40316.1 - 8.9e-08 31.9 0.6 2.9e-07 30.3 0.4 2.0 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EFE40316.1 - 0.033 14.3 0.3 0.033 14.3 0.3 4.0 4 1 1 5 5 5 0 G-patch domain SLT_2 PF13406.6 EFE40316.1 - 0.085 12.1 0.2 0.18 11.0 0.0 1.6 2 0 0 2 2 2 0 Transglycosylase SLT domain SSP160 PF06933.11 EFE40316.1 - 3.5 5.7 8.9 6.8 4.8 8.9 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Pkinase PF00069.25 EFE40317.1 - 1.9e-65 220.9 0.1 1.9e-63 214.3 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40317.1 - 7e-38 130.4 0.0 1.9e-37 129.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EFE40317.1 - 4.3e-17 61.6 0.4 7.9e-17 60.8 0.4 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 EFE40317.1 - 1.2e-06 27.8 0.0 1.9e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFE40317.1 - 4e-06 26.3 0.1 7.4e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFE40317.1 - 8.8e-06 25.2 0.0 0.00014 21.3 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFE40317.1 - 0.0023 17.9 0.1 0.16 11.9 0.1 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.11 EFE40317.1 - 0.012 15.3 0.1 0.02 14.5 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.22 EFE40317.1 - 0.025 14.2 0.5 0.073 12.7 0.5 1.7 1 1 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 EFE40317.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DAGK_cat PF00781.24 EFE40318.1 - 7.2e-26 90.3 0.0 1e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain LrgB PF04172.16 EFE40319.1 - 0.0086 15.6 1.3 0.0086 15.6 1.3 2.3 2 1 0 2 2 2 1 LrgB-like family DUF2569 PF10754.9 EFE40319.1 - 0.33 11.4 14.9 0.33 11.4 5.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2569) Adaptin_N PF01602.20 EFE40320.1 - 4.2e-95 319.3 11.0 9.1e-95 318.2 11.0 1.5 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 EFE40320.1 - 1.4e-57 193.5 0.6 3.2e-57 192.4 0.6 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 EFE40320.1 - 1.2e-55 186.9 0.0 4.4e-55 185.1 0.0 2.0 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 EFE40320.1 - 3.7e-12 46.6 11.0 1e-09 38.7 0.0 3.5 2 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFE40320.1 - 7.5e-10 39.1 0.4 4.8e-06 26.9 0.0 5.2 5 1 1 6 6 6 3 HEAT repeats HEAT PF02985.22 EFE40320.1 - 0.00035 20.6 1.1 1.7 9.1 0.1 5.3 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 EFE40320.1 - 0.0032 17.9 4.0 0.036 14.6 0.1 4.5 4 0 0 4 4 4 1 HEAT-like repeat AP4E_app_platf PF14807.6 EFE40320.1 - 0.0061 16.9 0.2 0.02 15.2 0.2 1.9 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform Arm PF00514.23 EFE40320.1 - 0.033 14.2 2.4 16 5.7 0.0 5.2 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat NBD94 PF16830.5 EFE40320.1 - 0.42 11.0 3.5 7.7 7.0 0.9 2.7 2 0 0 2 2 2 0 Nucleotide-Binding Domain 94 of RH MMS22L_C PF14911.6 EFE40320.1 - 0.47 9.5 10.6 0.049 12.7 0.6 3.5 3 1 1 4 4 4 0 S-phase genomic integrity recombination mediator, C-terminal DUF1542 PF07564.11 EFE40320.1 - 3.1 8.0 8.3 0.19 11.9 2.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) Vac_ImportDeg PF09783.9 EFE40321.1 - 4.7e-62 208.6 1.0 7.8e-62 207.8 1.0 1.3 1 0 0 1 1 1 1 Vacuolar import and degradation protein Mago_nashi PF02792.14 EFE40321.1 - 2.8e-55 186.4 0.6 5.9e-55 185.3 0.6 1.5 1 0 0 1 1 1 1 Mago nashi protein AGT PF11440.8 EFE40322.1 - 0.14 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 DNA alpha-glucosyltransferase Methyltransf_31 PF13847.6 EFE40323.1 - 1.6e-10 41.0 0.0 2.6e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE40323.1 - 8.8e-10 39.2 0.0 1.7e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE40323.1 - 2.3e-08 34.0 0.0 3.2e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE40323.1 - 5e-08 33.6 0.0 9.3e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE40323.1 - 5.2e-05 23.8 0.0 0.0001 22.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE40323.1 - 0.029 13.7 0.0 0.069 12.5 0.0 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CheR PF01739.18 EFE40323.1 - 0.045 13.2 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Isochorismatase PF00857.20 EFE40324.1 - 8.9e-35 120.4 0.1 3e-34 118.7 0.1 1.8 2 0 0 2 2 2 1 Isochorismatase family Iso_dh PF00180.20 EFE40324.1 - 1.9e-13 50.3 0.0 2.3e-12 46.7 0.0 2.1 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase TK PF00265.18 EFE40324.1 - 0.053 13.4 0.0 0.31 10.9 0.0 2.1 2 0 0 2 2 2 0 Thymidine kinase Methyltransf_25 PF13649.6 EFE40325.1 - 1.3e-10 41.9 0.0 4.2e-10 40.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE40325.1 - 2.7e-06 28.0 0.0 7.6e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE40325.1 - 1.7e-05 24.7 0.0 2.4e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE40325.1 - 3.6e-05 24.4 0.0 5.2e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE40325.1 - 8.2e-05 22.4 0.0 0.0001 22.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE40325.1 - 0.0069 15.8 0.0 0.009 15.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Abhydrolase_6 PF12697.7 EFE40326.1 - 5.4e-08 33.7 0.1 6.8e-08 33.4 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Rad60-SLD PF11976.8 EFE40328.1 - 1.9e-13 50.0 0.1 2.6e-13 49.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFE40328.1 - 1.1e-05 25.1 0.1 1.5e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Nup84_Nup100 PF04121.13 EFE40329.1 - 1.5e-178 595.3 2.8 1.9e-178 595.0 2.8 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 HBM PF16591.5 EFE40329.1 - 0.011 15.2 0.8 0.011 15.2 0.8 1.9 2 0 0 2 2 2 0 Helical bimodular sensor domain PEP-utilizers_C PF02896.18 EFE40329.1 - 0.17 11.0 0.0 0.34 10.0 0.0 1.5 1 0 0 1 1 1 0 PEP-utilising enzyme, TIM barrel domain Cation_ATPase_C PF00689.21 EFE40330.1 - 1.1e-45 155.6 4.4 1.1e-45 155.6 4.4 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFE40330.1 - 9.7e-35 119.7 3.6 9.7e-35 119.7 3.6 2.8 3 1 0 3 3 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFE40330.1 - 5.1e-24 84.2 0.0 9.6e-24 83.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFE40330.1 - 3.6e-17 63.4 0.9 3.3e-16 60.2 0.9 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFE40330.1 - 1.8e-06 27.6 0.1 1.3e-05 24.7 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFE40330.1 - 2.8e-05 24.0 0.4 9.2e-05 22.3 0.4 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RskA PF10099.9 EFE40330.1 - 0.0052 17.1 1.0 1.9 8.8 0.0 3.4 2 1 0 2 2 2 1 Anti-sigma-K factor rskA LptF_LptG PF03739.14 EFE40330.1 - 0.015 14.1 5.7 0.041 12.7 5.7 1.7 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG DUF1774 PF08611.10 EFE40330.1 - 0.18 12.1 5.3 0.13 12.6 0.4 2.8 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1774) BatA PF07584.11 EFE40330.1 - 5.1 7.5 6.1 4.3 7.8 0.1 3.4 4 0 0 4 4 3 0 Aerotolerance regulator N-terminal DUF2417 PF10329.9 EFE40330.1 - 7.4 5.9 7.5 4.2 6.7 0.1 3.3 3 0 0 3 3 3 0 Region of unknown function (DUF2417) TMEM171 PF15471.6 EFE40331.1 - 0.45 9.5 2.7 0.65 8.9 2.7 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Nucleo_P87 PF07267.11 EFE40331.1 - 1.7 7.4 8.0 2 7.2 8.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ligase_CoA PF00549.19 EFE40332.1 - 3e-34 118.0 1.8 1.6e-18 67.0 0.1 2.4 2 0 0 2 2 2 2 CoA-ligase CoA_binding PF02629.19 EFE40332.1 - 8.9e-14 52.0 1.4 2e-13 50.9 0.3 2.2 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.6 EFE40332.1 - 5e-08 32.8 1.0 2.5e-06 27.3 0.2 2.8 2 1 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EFE40332.1 - 0.011 16.2 0.0 0.036 14.5 0.1 1.8 2 0 0 2 2 2 0 CoA binding domain Citrate_bind PF16114.5 EFE40332.1 - 0.15 11.5 0.0 0.32 10.5 0.0 1.5 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding 4HBT PF03061.22 EFE40333.1 - 1.4e-10 41.3 0.0 2.6e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily V-ATPase_C PF03223.15 EFE40334.1 - 3.8e-120 401.7 0.0 4.6e-120 401.4 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C mRNA_cap_C PF03919.15 EFE40334.1 - 0.049 14.3 0.0 0.12 13.0 0.0 1.6 1 0 0 1 1 1 0 mRNA capping enzyme, C-terminal domain APS_kinase PF01583.20 EFE40335.1 - 1.7e-54 184.0 0.0 2.8e-54 183.3 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 EFE40335.1 - 1.6e-05 25.5 0.7 0.00053 20.5 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFE40335.1 - 0.00087 19.5 0.2 0.00087 19.5 0.2 2.8 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFE40335.1 - 0.0013 18.4 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EFE40335.1 - 0.0019 18.7 0.9 0.022 15.3 0.0 2.5 2 1 0 2 2 2 1 ABC transporter Zeta_toxin PF06414.12 EFE40335.1 - 0.003 16.8 0.2 0.0089 15.3 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin MetOD2 PF18548.1 EFE40335.1 - 0.0044 17.1 0.6 0.014 15.5 0.6 1.9 1 0 0 1 1 1 1 Metanogen output domain 2 RNA_helicase PF00910.22 EFE40335.1 - 0.058 13.8 0.0 0.18 12.2 0.0 1.8 2 0 0 2 2 2 0 RNA helicase CbiA PF01656.23 EFE40335.1 - 0.098 12.7 0.0 0.17 11.9 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain KTI12 PF08433.10 EFE40335.1 - 0.12 11.8 0.1 0.34 10.3 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_17 PF13207.6 EFE40335.1 - 0.7 10.3 8.7 1.2 9.6 0.1 3.1 2 2 1 3 3 3 0 AAA domain AAA_16 PF13191.6 EFE40335.1 - 9.2 6.6 10.2 1.1e+02 3.2 10.2 2.6 1 1 0 1 1 1 0 AAA ATPase domain GCV_T PF01571.21 EFE40336.1 - 6.9e-78 261.6 0.0 9.6e-78 261.1 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EFE40336.1 - 4.6e-17 61.7 0.3 1.2e-16 60.4 0.3 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Aa_trans PF01490.18 EFE40337.1 - 1.9e-20 73.0 42.7 1.1e-15 57.3 29.4 2.5 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein Ank_2 PF12796.7 EFE40338.1 - 1.6e-71 236.9 4.5 6.5e-17 61.9 0.1 8.1 2 2 5 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE40338.1 - 9.1e-54 179.2 1.0 9.4e-08 32.5 0.0 9.9 6 2 4 10 10 10 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE40338.1 - 5.6e-51 169.9 5.6 3.7e-07 30.3 0.0 10.7 5 2 4 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE40338.1 - 2.1e-41 135.2 1.3 0.0075 16.7 0.0 14.6 14 0 0 14 14 14 11 Ankyrin repeat Ank PF00023.30 EFE40338.1 - 1.2e-35 120.3 2.4 0.0014 19.0 0.1 12.4 13 0 0 13 13 13 8 Ankyrin repeat DUF812 PF05667.11 EFE40341.1 - 0.0028 16.6 11.7 0.035 13.0 6.6 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF812) DUF1380 PF07128.12 EFE40341.1 - 0.01 16.0 1.5 2 8.6 0.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1380) Fe-ADH_2 PF13685.6 EFE40341.1 - 0.019 14.7 1.3 0.039 13.6 0.2 1.9 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase Vps5 PF09325.10 EFE40341.1 - 0.024 14.2 0.3 0.024 14.2 0.3 2.3 2 0 0 2 2 2 0 Vps5 C terminal like DUF4208 PF13907.6 EFE40341.1 - 0.033 14.6 3.4 0.064 13.7 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) Sec34 PF04136.15 EFE40341.1 - 4.1 7.3 8.6 0.53 10.1 0.4 2.9 2 1 0 2 2 2 0 Sec34-like family COMPASS-Shg1 PF05205.12 EFE40342.1 - 0.11 13.3 6.4 4.6 8.0 0.2 3.8 3 1 0 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 Jnk-SapK_ap_N PF09744.9 EFE40342.1 - 1.4 9.1 8.8 2.3 8.4 0.0 3.7 4 0 0 4 4 4 0 JNK_SAPK-associated protein-1 Topoisom_bac PF01131.20 EFE40343.1 - 8.9e-94 314.8 0.0 8.7e-93 311.6 0.0 1.9 2 0 0 2 2 2 1 DNA topoisomerase Toprim PF01751.22 EFE40343.1 - 3.4e-12 46.5 0.0 6.3e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Toprim domain MFS_1 PF07690.16 EFE40344.1 - 1.1e-43 149.6 56.2 1.3e-42 146.0 54.2 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE40344.1 - 6.7e-10 38.4 35.5 1.6e-07 30.6 19.2 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 EFE40344.1 - 5.3e-06 25.1 22.1 8.3e-06 24.5 22.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) GATase PF00117.28 EFE40345.1 - 7e-14 52.0 0.0 9.3e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFE40345.1 - 0.046 13.5 0.2 0.18 11.5 0.2 2.1 1 1 0 1 1 1 0 Peptidase C26 GATase_3 PF07685.14 EFE40345.1 - 0.062 12.9 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DUF775 PF05603.12 EFE40346.1 - 8.3e-67 224.6 0.0 9.3e-67 224.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) NUDIX PF00293.28 EFE40347.1 - 1.4e-11 44.5 0.0 2.6e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4743 PF15916.5 EFE40347.1 - 9.1e-11 41.8 0.0 1.3e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) RNA_pol_Rpb8 PF03870.15 EFE40348.1 - 1.5e-46 158.0 0.0 1.7e-46 157.9 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 PAXNEB PF05625.11 EFE40349.1 - 1.6e-119 399.4 0.0 1.8e-119 399.2 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein tRNA_int_endo PF01974.17 EFE40350.1 - 2.5e-15 56.3 0.0 5.1e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain UPF0086 PF01868.16 EFE40351.1 - 2.8e-11 43.2 0.0 8e-08 32.1 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function UPF0086 Copper-bind PF00127.20 EFE40352.1 - 0.014 15.8 0.2 0.041 14.3 0.2 1.8 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family Ank_2 PF12796.7 EFE40353.1 - 1.7e-61 204.8 10.6 4.2e-11 43.3 0.0 6.3 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFE40353.1 - 2.1e-40 136.3 10.3 3.3e-09 36.8 0.0 7.3 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFE40353.1 - 4.7e-40 135.4 9.1 4.2e-08 33.6 0.1 8.9 5 4 4 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE40353.1 - 4.4e-31 103.4 2.0 0.0002 21.5 0.0 10.6 11 0 0 11 11 11 6 Ankyrin repeat Ank PF00023.30 EFE40353.1 - 1.3e-30 104.5 1.3 0.018 15.5 0.0 10.8 11 0 0 11 11 11 8 Ankyrin repeat Trehalase_Ca-bi PF07492.11 EFE40353.1 - 0.00021 20.9 1.0 1.4 8.8 0.0 4.2 4 0 0 4 4 4 2 Neutral trehalase Ca2+ binding domain PsaM PF07465.13 EFE40353.1 - 9.4 6.1 0.0 9.4 6.1 0.0 4.0 7 0 0 7 7 7 0 Photosystem I protein M (PsaM) MFS_1 PF07690.16 EFE40354.1 - 8.8e-09 34.7 15.6 0.00017 20.6 7.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Tmemb_170 PF10190.9 EFE40354.1 - 0.0058 17.0 5.7 0.0058 17.0 5.7 3.3 3 0 0 3 3 3 1 Putative transmembrane protein 170 Peptidase_U4 PF03419.13 EFE40354.1 - 1.2 8.3 11.6 0.21 10.9 1.5 2.2 2 0 0 2 2 2 0 Sporulation factor SpoIIGA FYVE_2 PF02318.16 EFE40355.1 - 0.89 9.8 14.8 1.7 8.8 3.9 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger Siva PF05458.12 EFE40355.1 - 1.5 8.4 11.3 1.6 8.4 2.8 2.5 2 0 0 2 2 2 0 Cd27 binding protein (Siva) FSA_C PF10479.9 EFE40355.1 - 1.7 6.7 6.1 2.4 6.2 6.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Zn_ribbon_17 PF17120.5 EFE40355.1 - 2.4 7.8 18.8 0.33 10.6 6.0 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EFE40355.1 - 7.1 6.7 19.4 5.8 7.0 3.7 3.0 2 0 0 2 2 2 0 RING-type zinc-finger Cofilin_ADF PF00241.20 EFE40357.1 - 0.0017 18.2 0.0 0.0028 17.4 0.0 1.3 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein CinA_KH PF18146.1 EFE40358.1 - 0.026 14.7 0.0 0.036 14.2 0.0 1.2 1 0 0 1 1 1 0 Damage-inducible protein CinA KH domain MoCF_biosynth PF00994.24 EFE40358.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Probable molybdopterin binding domain GATase PF00117.28 EFE40359.1 - 1.2e-47 162.2 0.0 3.7e-47 160.6 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EFE40359.1 - 1.9e-44 150.5 0.0 8.8e-44 148.4 0.0 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 EFE40359.1 - 2.8e-05 24.0 0.3 0.001 18.9 0.3 2.4 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 EFE40359.1 - 0.035 13.9 0.0 0.058 13.2 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family RNA_pol_I_A49 PF06870.12 EFE40360.1 - 1.5e-67 228.2 0.0 1.7e-67 228.0 0.0 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Aminotran_1_2 PF00155.21 EFE40361.1 - 7.7e-86 288.5 0.0 1.3e-85 287.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFE40361.1 - 2.4e-06 26.3 0.0 4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EFE40361.1 - 1.5e-05 24.5 0.2 2.7e-05 23.6 0.2 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EFE40361.1 - 0.0011 18.0 0.0 0.0023 16.9 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V p450 PF00067.22 EFE40362.1 - 9.2e-21 74.1 0.0 1.1e-20 73.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CDI PF02234.19 EFE40362.1 - 0.013 15.6 0.5 0.034 14.4 0.5 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor p450 PF00067.22 EFE40363.1 - 1.7e-64 218.3 0.0 2.2e-64 217.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Vps54 PF07928.12 EFE40364.1 - 7.5e-46 155.9 1.2 2.8e-45 154.0 1.2 2.1 1 0 0 1 1 1 1 Vps54-like protein Vps54_N PF10475.9 EFE40364.1 - 0.00014 21.3 0.9 0.00014 21.3 0.9 2.0 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex SNF2_N PF00176.23 EFE40365.1 - 2e-70 237.3 0.6 2e-70 237.3 0.6 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.25 EFE40365.1 - 1.4e-25 89.2 0.4 1.7e-24 85.7 0.7 2.4 2 0 0 2 2 2 1 Bromodomain Helicase_C PF00271.31 EFE40365.1 - 2.2e-19 69.9 0.3 6.2e-18 65.2 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 EFE40365.1 - 4.6e-19 68.5 11.0 4.6e-19 68.5 11.0 3.1 3 0 0 3 3 3 1 HSA QLQ PF08880.11 EFE40365.1 - 2.6e-13 49.5 4.8 2.6e-13 49.5 4.8 2.7 2 0 0 2 2 2 1 QLQ SnAC PF14619.6 EFE40365.1 - 2.6e-13 50.4 0.1 2.6e-13 50.4 0.1 3.7 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 EFE40365.1 - 2.2e-09 37.5 0.4 1.2e-08 35.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DehI PF10778.9 EFE40365.1 - 0.22 11.7 0.1 0.22 11.7 0.1 2.3 2 1 0 2 2 2 0 Halocarboxylic acid dehydrogenase DehI BAR PF03114.18 EFE40366.1 - 3.8e-34 118.4 13.6 8.9e-33 113.9 13.6 2.0 1 1 0 1 1 1 1 BAR domain BAR_2 PF10455.9 EFE40366.1 - 4.9e-07 29.2 6.7 7.4e-07 28.6 6.7 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF2894 PF11445.8 EFE40366.1 - 1.5 9.3 6.9 0.37 11.2 3.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) APG6_N PF17675.1 EFE40366.1 - 2.3 8.7 15.5 3.2 8.3 11.6 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region TMPIT PF07851.13 EFE40366.1 - 5.3 6.2 7.3 9.5 5.4 7.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein Ada_Zn_binding PF02805.16 EFE40368.1 - 2.2e-29 101.3 4.3 4.1e-29 100.4 4.3 1.5 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.23 EFE40368.1 - 3.3e-07 30.2 0.0 7.6e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 EFE40368.1 - 0.0004 20.6 0.0 0.00086 19.5 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain SUIM_assoc PF16619.5 EFE40368.1 - 3.9 7.6 11.1 0.092 12.8 4.1 2.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF908 PF06012.12 EFE40368.1 - 7.5 5.9 9.7 12 5.2 9.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Ribosomal_L2_C PF03947.18 EFE40369.1 - 1.6e-41 141.4 5.9 2.8e-41 140.6 5.9 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EFE40369.1 - 3.8e-13 49.2 0.1 9.6e-13 47.9 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain WHIM1 PF15612.6 EFE40370.1 - 3e-08 33.0 0.0 6.3e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 PT PF04886.12 EFE40370.1 - 0.0051 16.3 3.1 0.0051 16.3 3.1 3.1 4 0 0 4 4 4 1 PT repeat PfkB PF00294.24 EFE40371.1 - 5e-66 223.0 0.1 6.7e-66 222.6 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EFE40371.1 - 2.7e-05 23.7 0.0 4.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DUF5450 PF17529.2 EFE40371.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5450) EST1_DNA_bind PF10373.9 EFE40372.1 - 6.9e-58 196.3 4.3 1.1e-57 195.7 4.3 1.3 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EFE40372.1 - 2.4e-23 83.3 0.4 9e-23 81.4 0.2 2.1 3 0 0 3 3 3 1 Telomerase activating protein Est1 Acyl-CoA_dh_1 PF00441.24 EFE40373.1 - 1.7e-31 109.4 1.9 3.3e-31 108.5 1.9 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFE40373.1 - 2.5e-19 69.3 0.0 4.3e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EFE40373.1 - 5.7e-15 56.0 0.2 1.4e-14 54.7 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EFE40373.1 - 5.4e-14 52.6 5.6 1e-13 51.7 5.6 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain IGPD PF00475.18 EFE40374.1 - 8.4e-58 194.8 1.3 1.2e-57 194.3 1.3 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Spo12 PF05032.12 EFE40375.1 - 3.1e-14 52.6 0.4 7e-14 51.4 0.4 1.6 1 0 0 1 1 1 1 Spo12 family Sad1_UNC PF07738.13 EFE40376.1 - 3.1e-31 108.1 0.0 5.5e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal KRAP_IP3R_bind PF14722.6 EFE40376.1 - 0.01 15.6 0.6 0.039 13.7 0.6 1.9 1 0 0 1 1 1 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain Pkinase PF00069.25 EFE40378.1 - 1.1e-51 175.8 0.0 1.5e-51 175.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40378.1 - 9.8e-33 113.5 0.0 1.4e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE40378.1 - 4.9e-10 39.2 0.0 4.6e-07 29.4 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EFE40378.1 - 0.06 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE40378.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pep3_Vps18 PF05131.14 EFE40382.1 - 2.9e-45 153.7 0.0 8.4e-45 152.2 0.0 1.8 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EFE40382.1 - 1.1e-10 41.6 1.3 1.3e-05 25.1 0.0 3.3 3 0 0 3 3 3 2 Region in Clathrin and VPS Zn_ribbon_17 PF17120.5 EFE40382.1 - 0.00018 21.1 0.2 0.00038 20.0 0.2 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EFE40382.1 - 0.00095 19.0 1.0 0.0024 17.6 1.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE40382.1 - 0.00097 19.1 0.8 0.0024 17.8 0.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain DUF2175 PF09943.9 EFE40382.1 - 0.0012 19.1 1.0 0.0097 16.2 0.1 2.6 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_11 PF17123.5 EFE40382.1 - 0.002 17.9 4.3 0.002 17.9 4.3 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 EFE40382.1 - 0.0046 17.3 0.8 0.012 15.9 0.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFE40382.1 - 0.038 14.0 0.8 0.098 12.7 0.8 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Vps39_2 PF10367.9 EFE40382.1 - 0.048 14.1 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-rbx1 PF12678.7 EFE40382.1 - 0.057 13.7 0.8 0.29 11.4 0.6 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFE40382.1 - 0.37 10.7 3.0 0.14 12.0 0.3 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Phage_holin_3_6 PF07332.11 EFE40383.1 - 0.0021 18.1 2.7 0.0021 18.1 2.7 1.5 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III SNF2_N PF00176.23 EFE40384.1 - 3.4e-65 220.1 1.8 6.2e-65 219.2 1.8 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 EFE40384.1 - 2.4e-40 138.0 15.6 2.4e-40 138.0 15.6 5.1 4 1 1 5 5 5 1 DNA-binding domain Helicase_C PF00271.31 EFE40384.1 - 4.1e-19 69.0 0.0 1.1e-18 67.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE40384.1 - 1.4e-06 28.4 3.3 3e-06 27.4 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFE40384.1 - 0.00014 21.7 0.0 0.00046 20.0 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase YgaB PF14182.6 EFE40384.1 - 0.0021 18.4 5.3 0.009 16.4 2.0 3.1 2 0 0 2 2 2 1 YgaB-like protein HDA2-3 PF11496.8 EFE40384.1 - 0.0096 15.1 2.8 0.051 12.7 0.0 3.1 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 baeRF_family12 PF18856.1 EFE40384.1 - 0.014 16.0 0.2 0.014 16.0 0.2 4.7 5 1 0 5 5 5 0 Bacterial archaeo-eukaryotic release factor family 12 Endotoxin_C2 PF18449.1 EFE40384.1 - 0.46 10.8 9.2 0.023 15.0 2.1 2.4 2 0 0 2 2 2 0 Delta endotoxin Na_H_Exchanger PF00999.21 EFE40385.1 - 8.8e-63 212.4 36.3 6.6e-62 209.5 36.3 2.0 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family TYA PF01021.19 EFE40385.1 - 0.047 14.0 0.5 0.087 13.2 0.5 1.3 1 0 0 1 1 1 0 TYA transposon protein Pox_EPC_I2-L1 PF12575.8 EFE40385.1 - 2.2 8.5 0.0 2.2 8.5 0.0 3.6 3 1 0 3 3 3 0 Poxvirus entry protein complex L1 and I2 MFS_2 PF13347.6 EFE40387.1 - 2.7e-07 29.5 3.1 2.7e-07 29.5 3.1 2.0 2 1 0 2 2 2 1 MFS/sugar transport protein T2SSG PF08334.11 EFE40388.1 - 0.054 13.6 0.0 0.066 13.3 0.0 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G STE PF02200.16 EFE40389.1 - 1.6e-56 189.5 0.1 2.6e-56 188.8 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 EFE40389.1 - 0.0021 18.4 3.4 0.0064 16.9 3.4 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE40389.1 - 0.093 13.6 2.3 0.3 12.0 2.3 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger DUF4602 PF15375.6 EFE40390.1 - 1.1e-12 48.5 6.1 1.1e-12 48.5 6.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4602) His_biosynth PF00977.21 EFE40391.1 - 1.2e-28 100.1 0.0 1e-14 54.5 0.0 2.0 2 0 0 2 2 2 2 Histidine biosynthesis protein Ribul_P_3_epim PF00834.19 EFE40391.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Radical_SAM_C PF16199.5 EFE40392.1 - 1.4e-32 111.5 0.1 4.2e-32 110.0 0.0 1.8 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EFE40392.1 - 3.6e-17 63.3 0.0 1.5e-16 61.2 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EFE40392.1 - 9.8e-10 38.7 0.0 1.8e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE40392.1 - 1e-06 28.7 0.2 1.2e-05 25.2 0.0 2.4 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE40392.1 - 0.08 13.4 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ligase_CoA PF00549.19 EFE40393.1 - 1.4e-22 80.1 0.3 2.5e-22 79.4 0.3 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 EFE40393.1 - 1.5e-12 48.0 1.9 4.4e-12 46.5 0.4 2.2 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.6 EFE40393.1 - 2e-08 34.1 0.1 4.3e-08 33.0 0.1 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain Ribosomal_L5_C PF00673.21 EFE40394.1 - 2.7e-28 98.0 0.0 5.3e-28 97.0 0.0 1.5 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EFE40394.1 - 7.1e-06 26.3 0.0 1.4e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 Pkinase PF00069.25 EFE40395.1 - 3e-69 233.3 0.0 1.1e-68 231.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40395.1 - 2e-47 161.6 0.0 4.7e-47 160.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EFE40395.1 - 4.2e-28 97.6 0.0 8.3e-28 96.7 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 Kinase-like PF14531.6 EFE40395.1 - 6.2e-08 32.3 0.0 0.00027 20.3 0.0 2.3 2 0 0 2 2 2 2 Kinase-like SAM_1 PF00536.30 EFE40395.1 - 6.2e-06 26.6 0.0 1.5e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EFE40395.1 - 8.6e-05 23.1 0.0 0.00017 22.2 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Pkinase_fungal PF17667.1 EFE40395.1 - 0.0026 16.6 0.9 0.0049 15.7 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase SAM_2 PF07647.17 EFE40395.1 - 0.0087 16.1 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 EFE40395.1 - 0.029 14.3 0.1 0.064 13.2 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Kdo PF06293.14 EFE40395.1 - 0.08 12.3 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EFE40395.1 - 0.2 10.7 0.1 0.92 8.5 0.0 2.1 3 0 0 3 3 3 0 Seadornavirus VP7 MSA-2c PF12238.8 EFE40395.1 - 1.1 9.3 4.6 1.2 9.1 0.0 2.9 2 0 0 2 2 2 0 Merozoite surface antigen 2c Fungal_trans PF04082.18 EFE40396.1 - 6.6e-16 58.1 0.6 1.4e-15 57.0 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain FAM176 PF14851.6 EFE40396.1 - 0.002 17.8 0.1 0.0042 16.8 0.1 1.5 1 0 0 1 1 1 1 FAM176 family PBP1_TM PF14812.6 EFE40396.1 - 0.028 14.8 6.0 0.054 13.9 6.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal HAND PF09110.11 EFE40396.1 - 0.63 10.8 4.3 1.4 9.7 0.0 2.3 2 0 0 2 2 2 0 HAND Sporozoite_P67 PF05642.11 EFE40396.1 - 0.68 7.9 15.9 0.012 13.8 8.5 1.6 2 0 0 2 2 2 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.10 EFE40396.1 - 0.99 9.8 9.8 2.5 8.6 9.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Radial_spoke PF04712.12 EFE40396.1 - 5.2 5.9 5.6 8.1 5.3 5.6 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein MMR_HSR1 PF01926.23 EFE40397.1 - 2.2e-16 60.0 0.4 2.2e-14 53.5 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFE40397.1 - 1.9e-06 27.5 0.6 3.2e-05 23.5 0.2 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFE40397.1 - 0.0001 22.2 0.1 0.022 14.7 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 EFE40397.1 - 0.0019 17.6 0.1 0.0037 16.6 0.1 1.4 1 0 0 1 1 1 1 AIG1 family Ribosomal_60s PF00428.19 EFE40397.1 - 0.24 12.0 7.4 0.81 10.3 7.4 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein Dynamin_N PF00350.23 EFE40397.1 - 0.52 10.3 7.0 0.31 11.1 0.5 3.1 3 1 1 4 4 4 0 Dynamin family LTV PF04180.14 EFE40398.1 - 2.3e-101 340.3 16.2 2.8e-101 340.0 16.2 1.0 1 0 0 1 1 1 1 Low temperature viability protein DUF5395 PF17373.2 EFE40398.1 - 0.029 15.0 0.0 0.063 13.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5395) PLDc_2 PF13091.6 EFE40399.1 - 3.2e-09 36.8 0.0 0.00042 20.2 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EFE40399.1 - 3.2e-09 36.6 2.7 0.0017 18.5 0.4 3.2 2 1 0 2 2 2 2 Phospholipase D Active site motif Methyltransf_25 PF13649.6 EFE40400.1 - 2.9e-28 98.4 0.1 1.8e-15 57.4 0.0 4.1 4 0 0 4 4 4 2 Methyltransferase domain Methyltransf_11 PF08241.12 EFE40400.1 - 1.4e-27 96.2 0.0 3.9e-12 46.7 0.0 3.4 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.6 EFE40400.1 - 1.1e-17 64.2 0.0 3e-10 40.1 0.0 3.1 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.6 EFE40400.1 - 2e-17 63.5 0.0 7.9e-10 38.8 0.0 2.8 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFE40400.1 - 6.4e-12 46.1 0.0 8.8e-07 29.6 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain CMAS PF02353.20 EFE40400.1 - 1.1e-08 34.7 0.0 8e-08 31.9 0.0 2.0 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase TPR_2 PF07719.17 EFE40400.1 - 5.3e-08 32.4 1.7 0.098 12.8 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat MetW PF07021.12 EFE40400.1 - 5.6e-08 32.6 0.0 0.0014 18.3 0.0 2.4 2 0 0 2 2 2 2 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.18 EFE40400.1 - 9.5e-08 31.7 0.0 0.00029 20.2 0.0 2.4 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family TPR_8 PF13181.6 EFE40400.1 - 1.9e-06 27.7 0.9 0.11 12.8 0.0 5.8 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFE40400.1 - 3e-06 27.6 17.5 0.032 15.0 0.0 7.5 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFE40400.1 - 3e-06 27.6 8.4 0.04 14.4 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat NodS PF05401.11 EFE40400.1 - 5e-06 26.3 0.0 0.0011 18.6 0.0 2.4 2 0 0 2 2 2 1 Nodulation protein S (NodS) GidB PF02527.15 EFE40400.1 - 0.00014 21.2 0.0 0.024 14.0 0.0 2.3 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G MTS PF05175.14 EFE40400.1 - 0.00048 19.7 0.0 0.0054 16.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain TPR_17 PF13431.6 EFE40400.1 - 0.0014 18.8 0.0 7.6 7.2 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFE40400.1 - 0.0016 18.2 3.7 0.03 14.1 0.1 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFE40400.1 - 0.0024 18.5 7.7 5.5 7.7 0.0 6.3 7 0 0 7 7 5 1 Tetratricopeptide repeat TehB PF03848.14 EFE40400.1 - 0.014 14.8 0.0 0.046 13.1 0.0 1.8 2 0 0 2 2 2 0 Tellurite resistance protein TehB NNMT_PNMT_TEMT PF01234.17 EFE40400.1 - 0.015 14.5 0.0 0.15 11.2 0.0 2.4 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Spermine_synth PF01564.17 EFE40400.1 - 0.026 13.9 0.0 0.068 12.6 0.0 1.6 1 0 0 1 1 1 0 Spermine/spermidine synthase domain TPR_20 PF14561.6 EFE40400.1 - 0.041 14.2 1.9 17 5.9 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Metaviral_G PF09595.10 EFE40400.1 - 0.096 12.8 3.7 0.22 11.6 3.7 1.5 1 0 0 1 1 1 0 Metaviral_G glycoprotein FtsJ PF01728.19 EFE40400.1 - 0.12 12.4 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 FtsJ-like methyltransferase TetR_N PF00440.23 EFE40400.1 - 0.14 12.0 0.0 0.47 10.3 0.0 2.0 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family CheR PF01739.18 EFE40400.1 - 0.17 11.3 0.0 3.7 7.0 0.0 2.6 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_2 PF00891.18 EFE40402.1 - 3.3e-19 69.0 0.1 7.1e-19 67.9 0.0 1.5 2 0 0 2 2 2 1 O-methyltransferase domain p450 PF00067.22 EFE40402.1 - 2.6e-08 33.1 0.1 7.3e-08 31.6 0.0 1.6 2 0 0 2 2 2 1 Cytochrome P450 Methyltransf_25 PF13649.6 EFE40402.1 - 0.00061 20.4 0.0 0.0015 19.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_3 PF09069.11 EFE40402.1 - 0.18 12.2 0.0 0.56 10.7 0.0 1.8 2 0 0 2 2 2 0 EF-hand p450 PF00067.22 EFE40403.1 - 2.8e-19 69.2 0.0 4.9e-19 68.4 0.0 1.3 2 0 0 2 2 2 1 Cytochrome P450 PADR1 PF08063.12 EFE40403.1 - 0.1 12.4 0.1 5.3 6.9 0.0 2.3 2 0 0 2 2 2 0 PADR1 (NUC008) domain RIX1 PF08167.12 EFE40404.1 - 3.5e-23 82.3 0.1 4e-23 82.1 0.1 1.0 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis Terminase_6C PF17289.2 EFE40404.1 - 0.04 14.0 0.0 0.043 13.9 0.0 1.2 1 0 0 1 1 1 0 Terminase RNaseH-like domain MBOAT_2 PF13813.6 EFE40406.1 - 4.2e-21 75.0 1.7 8.8e-21 74.0 1.7 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Big_4 PF07532.11 EFE40406.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 4) SNF2_N PF00176.23 EFE40407.1 - 9.4e-71 238.3 0.0 4.9e-70 236.0 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE40407.1 - 1.1e-15 58.0 0.0 5.1e-15 55.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HIRAN PF08797.11 EFE40407.1 - 8.6e-15 54.5 0.0 1.9e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain zf-C3HC4_2 PF13923.6 EFE40407.1 - 3.5e-10 39.5 7.4 1.2e-09 37.9 7.4 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFE40407.1 - 1.1e-08 35.3 6.9 1.1e-08 35.3 6.9 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFE40407.1 - 6.4e-08 32.3 8.1 6.4e-08 32.3 8.1 2.8 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE40407.1 - 1e-06 28.5 8.1 3e-06 27.0 8.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFE40407.1 - 1e-06 28.9 3.6 3.5e-06 27.2 3.6 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EFE40407.1 - 1.3e-05 24.8 2.8 1.3e-05 24.8 2.8 2.8 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_5 PF14634.6 EFE40407.1 - 1.6e-05 24.8 5.1 1.6e-05 24.8 5.1 1.9 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFE40407.1 - 2.7e-05 24.1 8.0 2.7e-05 24.1 8.0 2.2 2 0 0 2 2 2 1 RING-type zinc-finger DEAD PF00270.29 EFE40407.1 - 5.5e-05 23.0 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Prok-RING_4 PF14447.6 EFE40407.1 - 0.00011 22.0 8.7 0.00028 20.7 8.7 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFE40407.1 - 0.00088 19.4 8.5 0.0019 18.3 8.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EFE40407.1 - 0.0019 17.9 4.3 0.019 14.8 4.6 2.3 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 EFE40407.1 - 0.017 15.3 0.1 0.073 13.3 0.0 2.1 2 0 0 2 2 1 0 U-box domain zf-ANAPC11 PF12861.7 EFE40407.1 - 0.16 12.1 1.8 0.6 10.2 1.9 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RBM39linker PF15519.6 EFE40407.1 - 2.4 9.3 5.0 8.8 7.5 2.8 2.8 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein SNF2_N PF00176.23 EFE40408.1 - 9.6e-47 159.4 0.1 2e-46 158.3 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE40408.1 - 2.2e-17 63.4 0.0 5.6e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE40408.1 - 2.3e-07 31.0 0.0 7.3e-07 29.3 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFE40408.1 - 8.3e-05 21.9 0.0 0.00018 20.8 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 EFE40408.1 - 0.00014 21.6 0.0 0.042 13.5 0.0 2.5 2 0 0 2 2 2 2 SWI2/SNF2 ATPase SAM_1 PF00536.30 EFE40408.1 - 0.032 14.7 0.0 0.091 13.2 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFE40408.1 - 0.05 13.7 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) GSH_synth_ATP PF03917.17 EFE40409.1 - 3.8e-133 443.9 0.0 4.4e-133 443.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EFE40409.1 - 1.1e-27 96.5 0.0 1.9e-27 95.7 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Bestrophin PF01062.21 EFE40413.1 - 7.1e-20 71.6 0.0 9.4e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Aminotran_3 PF00202.21 EFE40415.1 - 9.5e-126 419.7 0.0 1.1e-125 419.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EFE40415.1 - 0.0092 15.2 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II PPP5 PF08321.12 EFE40416.1 - 1.8e-34 117.9 0.2 4.2e-34 116.7 0.2 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region Metallophos PF00149.28 EFE40416.1 - 1.4e-31 110.7 0.0 1.9e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 EFE40416.1 - 3.7e-11 42.3 4.3 0.00012 21.7 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFE40416.1 - 5.6e-11 41.9 3.4 2.9e-06 26.8 0.1 3.3 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.17 EFE40416.1 - 4.4e-09 35.8 4.0 0.0049 16.9 0.5 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFE40416.1 - 5e-06 27.0 3.0 0.17 12.6 0.1 3.4 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFE40416.1 - 1.3e-05 25.2 0.1 0.019 15.1 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFE40416.1 - 0.0014 19.0 0.8 0.78 10.3 0.0 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFE40416.1 - 0.0025 18.1 0.8 5.4 7.6 0.0 3.5 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE40416.1 - 0.0031 17.8 0.2 0.016 15.5 0.2 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFE40416.1 - 0.0065 17.0 0.9 9.2 7.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFE40416.1 - 0.025 15.4 0.7 20 6.4 0.1 3.3 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFE40416.1 - 0.033 14.4 0.4 0.29 11.5 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFE40416.1 - 0.16 12.1 0.2 2 8.6 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EFE40416.1 - 0.24 11.5 5.2 0.97 9.6 0.1 2.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain DUF89 PF01937.19 EFE40417.1 - 2.7e-107 358.8 0.0 3e-107 358.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 CENP-F_leu_zip PF10473.9 EFE40417.1 - 0.0031 17.6 0.1 0.013 15.5 0.2 1.9 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cut12 PF11500.8 EFE40418.1 - 1.1e-47 161.6 15.2 1.1e-47 161.6 15.2 4.3 3 1 1 5 5 5 1 Spindle pole body formation-associated protein DUF2730 PF10805.8 EFE40418.1 - 6.9 6.8 9.4 0.66 10.1 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) HGTP_anticodon2 PF12745.7 EFE40419.1 - 1.2e-85 287.3 1.4 8.3e-85 284.5 0.0 2.2 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 EFE40419.1 - 7.9e-70 235.2 0.0 4.6e-37 127.8 0.0 3.6 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40419.1 - 9.4e-36 123.4 0.0 1.2e-18 67.3 0.0 3.6 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 EFE40419.1 - 1.1e-17 64.4 1.9 1.9e-17 63.6 0.3 2.3 2 0 0 2 2 2 1 RWD domain tRNA-synt_His PF13393.6 EFE40419.1 - 3.8e-07 29.7 3.1 4.3e-05 22.9 0.0 3.1 2 1 0 2 2 2 1 Histidyl-tRNA synthetase APH PF01636.23 EFE40419.1 - 0.0048 16.9 0.1 0.0048 16.9 0.1 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EFE40419.1 - 0.12 11.9 0.0 1.2 8.7 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EFE40419.1 - 0.88 8.3 3.7 0.47 9.2 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase Torus PF16131.5 EFE40420.1 - 4.2e-45 152.9 2.5 4.6e-45 152.8 0.0 2.3 3 0 0 3 3 3 1 Torus domain RRM_1 PF00076.22 EFE40420.1 - 2.2e-08 33.8 0.0 4.4e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EFE40420.1 - 0.00026 20.9 1.0 0.00047 20.1 1.0 1.4 1 0 0 1 1 1 1 Zinc finger domain Nup35_RRM_2 PF14605.6 EFE40420.1 - 0.0014 18.6 0.0 0.0025 17.8 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Ifi-6-16 PF06140.13 EFE40420.1 - 0.02 14.8 1.9 0.035 14.0 1.9 1.3 1 0 0 1 1 1 0 Interferon-induced 6-16 family zf-CCCH PF00642.24 EFE40420.1 - 0.026 14.4 1.7 0.047 13.6 1.7 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFE40420.1 - 1.2 9.1 3.8 1.9 8.4 3.8 1.3 1 0 0 1 1 1 0 CCCH-type zinc finger MMR_HSR1 PF01926.23 EFE40421.1 - 2e-20 72.9 0.0 3.4e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EFE40421.1 - 1.6e-19 69.9 0.0 1.3e-17 63.7 0.0 2.3 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 EFE40421.1 - 1.1e-12 47.8 0.0 1.6e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFE40421.1 - 3.7e-05 23.8 0.3 0.031 14.3 0.0 2.2 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 EFE40421.1 - 0.06 12.7 0.0 0.086 12.2 0.0 1.2 1 0 0 1 1 1 0 AIG1 family MeaB PF03308.16 EFE40421.1 - 0.074 12.0 0.1 0.13 11.2 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MCM PF00493.23 EFE40421.1 - 0.088 11.9 0.0 0.23 10.5 0.0 1.7 2 0 0 2 2 2 0 MCM P-loop domain DnaJ_C PF01556.18 EFE40422.1 - 5e-36 124.0 0.5 6.6e-36 123.6 0.5 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFE40422.1 - 1.1e-23 83.1 1.4 2.5e-22 78.8 1.4 2.3 1 1 0 1 1 1 1 DnaJ domain PIG-X PF08320.12 EFE40423.1 - 2.4e-70 236.7 0.0 3.4e-70 236.2 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 RFX_DNA_binding PF02257.15 EFE40424.1 - 5.6e-27 94.2 0.1 1.5e-26 92.8 0.1 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain TB2_DP1_HVA22 PF03134.19 EFE40425.1 - 1.4e-19 69.8 14.8 1e-18 67.0 12.5 2.4 1 1 1 2 2 2 2 TB2/DP1, HVA22 family ATG101 PF07855.12 EFE40426.1 - 1.6e-54 184.1 0.1 1.8e-54 183.9 0.1 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 DUF2922 PF11148.8 EFE40426.1 - 0.0078 15.9 0.2 0.019 14.7 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2922) Peroxin-3 PF04882.12 EFE40427.1 - 1.5e-163 545.2 0.1 1.8e-163 544.9 0.1 1.0 1 0 0 1 1 1 1 Peroxin-3 Na_H_Exchanger PF00999.21 EFE40428.1 - 1.7e-58 198.3 44.1 2.4e-58 197.8 44.1 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family MFS_1 PF07690.16 EFE40429.1 - 3.8e-35 121.4 28.1 3.8e-35 121.4 28.1 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily zf-C4H2 PF10146.9 EFE40430.1 - 0.0067 16.8 8.5 0.016 15.6 8.5 1.5 1 0 0 1 1 1 1 Zinc finger-containing protein PRIMA1 PF16101.5 EFE40430.1 - 0.021 14.8 8.2 0.054 13.5 8.2 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Hydin_ADK PF17213.3 EFE40430.1 - 0.12 12.6 1.2 0.29 11.4 1.2 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Endostatin PF06482.11 EFE40430.1 - 0.92 8.9 4.2 1.8 7.9 4.2 1.5 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SRP-alpha_N PF04086.13 EFE40430.1 - 3.5 7.5 10.7 0.32 10.9 3.8 2.0 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal ThiF PF00899.21 EFE40431.1 - 1.1e-31 110.0 0.0 1.5e-31 109.7 0.0 1.0 1 0 0 1 1 1 1 ThiF family Ytp1 PF10355.9 EFE40432.1 - 8.3e-70 235.1 17.9 8.3e-70 235.1 17.9 2.2 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EFE40432.1 - 1.9e-09 37.3 2.4 1.9e-09 37.3 2.4 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF2427) DUF973 PF06157.11 EFE40432.1 - 0.037 13.1 5.2 0.067 12.2 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF973) ExoD PF06055.12 EFE40432.1 - 0.061 12.7 0.0 0.061 12.7 0.0 2.6 3 0 0 3 3 3 0 Exopolysaccharide synthesis, ExoD DUF3180 PF11377.8 EFE40432.1 - 0.84 9.8 10.8 2.1 8.5 5.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) Spc7 PF08317.11 EFE40433.1 - 0.0082 15.1 7.0 0.014 14.3 7.0 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein ASXH PF13919.6 EFE40433.1 - 0.013 15.5 2.0 0.027 14.5 0.1 2.4 2 0 0 2 2 2 0 Asx homology domain SKA1 PF07160.12 EFE40433.1 - 0.016 15.0 2.3 0.037 13.9 2.3 1.7 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Filament PF00038.21 EFE40433.1 - 0.019 14.6 7.3 0.037 13.6 7.3 1.4 1 0 0 1 1 1 0 Intermediate filament protein Pox_A_type_inc PF04508.12 EFE40433.1 - 0.038 13.8 3.8 0.51 10.3 0.6 2.8 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat HOOK PF05622.12 EFE40433.1 - 0.057 11.6 10.2 3.2 5.8 0.0 2.1 2 0 0 2 2 2 0 HOOK protein Herpes_UL25 PF01499.16 EFE40433.1 - 0.11 11.0 4.9 0.18 10.3 4.9 1.3 1 0 0 1 1 1 0 Herpesvirus UL25 family Golgin_A5 PF09787.9 EFE40433.1 - 0.11 11.9 8.8 0.21 11.0 8.8 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 EFE40433.1 - 0.18 11.3 4.9 0.57 9.7 4.9 1.8 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF4407 PF14362.6 EFE40433.1 - 0.32 10.3 7.5 0.58 9.5 7.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 EFE40433.1 - 0.38 9.3 4.1 0.58 8.7 4.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Cauli_AT PF03233.13 EFE40433.1 - 0.59 10.0 5.3 0.44 10.5 2.2 2.2 2 0 0 2 2 2 0 Aphid transmission protein DUF2570 PF10828.8 EFE40433.1 - 0.83 9.5 9.9 0.83 9.5 8.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) ACP_PD PF04336.12 EFE40433.1 - 0.88 10.0 2.9 2 8.9 1.6 2.2 2 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase Cnn_1N PF07989.11 EFE40433.1 - 1 9.6 8.5 22 5.3 6.9 2.8 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Phage_GPO PF05929.11 EFE40433.1 - 1.3 8.5 10.0 0.56 9.8 7.1 1.8 3 0 0 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase Fib_alpha PF08702.10 EFE40433.1 - 1.6 8.9 6.9 4 7.6 5.2 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ALMT PF11744.8 EFE40433.1 - 2 7.1 4.8 3.5 6.4 4.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter CENP-Q PF13094.6 EFE40433.1 - 3.7 7.7 15.3 4.2 7.5 10.9 2.5 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit PRKG1_interact PF15898.5 EFE40433.1 - 5.6 7.9 13.8 1.7e+02 3.2 4.4 3.8 3 1 1 4 4 4 0 cGMP-dependent protein kinase interacting domain V_ATPase_I PF01496.19 EFE40433.1 - 7.8 4.3 5.9 11 3.7 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMPIT PF07851.13 EFE40433.1 - 9.4 5.4 6.5 14 4.8 6.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein Glycos_transf_2 PF00535.26 EFE40434.1 - 6.4e-23 81.4 0.1 8.7e-21 74.5 0.1 3.0 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFE40434.1 - 4.2e-05 23.6 0.0 0.08 12.8 0.0 2.9 3 0 0 3 3 3 2 Glycosyltransferase like family 2 Dicty_CAR PF05462.11 EFE40435.1 - 1.4e-11 44.1 8.9 2e-11 43.6 8.9 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 EFE40435.1 - 3.5e-06 26.5 11.8 6.5e-06 25.6 11.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) Git3 PF11710.8 EFE40435.1 - 2.5e-05 24.2 8.3 3.9e-05 23.5 8.3 1.2 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.9 EFE40435.1 - 0.00024 20.6 2.1 0.00035 20.0 2.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 EFE40435.1 - 0.0008 18.8 1.3 0.00098 18.5 1.3 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Frizzled PF01534.17 EFE40435.1 - 0.0011 18.1 13.3 0.13 11.3 0.4 2.2 1 1 1 2 2 2 2 Frizzled/Smoothened family membrane region Cyclin PF08613.11 EFE40436.1 - 9.2e-37 126.9 1.2 9.6e-24 84.6 0.4 4.9 3 1 1 5 5 5 2 Cyclin SUIM_assoc PF16619.5 EFE40436.1 - 1.7e-05 24.8 25.4 0.0042 17.1 3.5 4.0 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 MMTV_SAg PF01054.17 EFE40436.1 - 0.11 12.0 0.9 0.25 10.9 0.3 1.9 2 0 0 2 2 2 0 Mouse mammary tumour virus superantigen RAB3GAP2_N PF14655.6 EFE40436.1 - 0.23 10.7 4.7 3.5 6.8 2.2 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Spt20 PF12090.8 EFE40436.1 - 1.6 8.3 36.1 0.36 10.4 10.0 3.1 3 0 0 3 3 3 0 Spt20 family RabGAP-TBC PF00566.18 EFE40437.1 - 3.1e-28 98.9 0.0 4.4e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SBE2 PF17076.5 EFE40438.1 - 9.3e-07 27.5 0.9 9.3e-07 27.5 0.9 2.0 2 0 0 2 2 2 1 SBE2, cell-wall formation TFIIA PF03153.13 EFE40438.1 - 1.5 8.8 21.2 2 8.4 20.9 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF702 PF05142.12 EFE40438.1 - 7.8 7.0 9.5 12 6.4 1.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF702) SARAF PF06682.12 EFE40439.1 - 0.025 14.2 1.9 0.029 14.0 1.9 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Telomerase_RBD PF12009.8 EFE40440.1 - 1.4e-48 164.4 0.0 3.3e-48 163.2 0.0 1.7 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EFE40440.1 - 9.8e-12 44.9 0.0 2.4e-07 30.5 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RhoGEF PF00621.20 EFE40441.1 - 5.2e-37 127.8 0.1 2.6e-36 125.6 0.0 2.3 2 0 0 2 2 2 1 RhoGEF domain Peptidase_C48 PF02902.19 EFE40442.1 - 1.6e-13 51.0 0.6 9.4e-13 48.5 0.6 2.2 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Consortin_C PF15281.6 EFE40442.1 - 0.064 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Consortin C-terminus PrpF PF04303.13 EFE40443.1 - 2.7e-106 355.7 0.2 3.1e-106 355.5 0.2 1.0 1 0 0 1 1 1 1 PrpF protein tRNA-synt_1d PF00750.19 EFE40444.1 - 8e-92 307.9 0.3 1.3e-91 307.1 0.3 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFE40444.1 - 2.7e-23 82.4 0.9 8.3e-23 80.8 0.1 2.1 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EFE40444.1 - 0.017 15.7 0.0 0.051 14.2 0.0 1.9 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 EFE40444.1 - 0.098 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DAP3 PF10236.9 EFE40446.1 - 4.8e-85 285.5 0.0 7.8e-85 284.8 0.0 1.3 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 T2SSE PF00437.20 EFE40446.1 - 0.067 12.2 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 EFE40446.1 - 0.1 11.8 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RRS1 PF04939.12 EFE40447.1 - 2.1e-55 187.0 2.2 2.5e-55 186.8 2.2 1.1 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) Ribosomal_L41 PF05162.13 EFE40447.1 - 0.61 10.2 11.4 0.071 13.2 5.7 2.3 2 0 0 2 2 2 0 Ribosomal protein L41 DUF883 PF05957.13 EFE40449.1 - 0.13 12.9 5.3 0.53 10.9 5.3 2.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) ATP-synt_B PF00430.18 EFE40449.1 - 0.19 11.8 5.8 0.57 10.3 5.8 1.8 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Ran_BP1 PF00638.18 EFE40450.1 - 2.4e-52 176.4 1.5 3.6e-52 175.8 1.5 1.3 1 0 0 1 1 1 1 RanBP1 domain VID27_PH PF17747.1 EFE40450.1 - 0.00052 20.3 0.1 0.0007 19.8 0.1 1.2 1 0 0 1 1 1 1 VID27 PH-like domain WH1 PF00568.23 EFE40450.1 - 0.002 18.0 0.4 0.013 15.5 0.4 2.0 1 1 0 1 1 1 1 WH1 domain YEATS PF03366.16 EFE40451.1 - 1.1e-09 38.1 0.0 2.1e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 YEATS family BET PF17035.5 EFE40451.1 - 0.023 14.8 0.1 0.042 14.0 0.1 1.4 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation Phosducin PF02114.16 EFE40452.1 - 8.9e-15 54.3 0.0 3.7e-14 52.3 0.0 1.9 1 1 0 1 1 1 1 Phosducin DNA_pol_phi PF04931.13 EFE40452.1 - 5.4 5.0 6.4 8.4 4.4 6.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi UPF0560 PF10577.9 EFE40453.1 - 0.24 9.9 0.4 0.29 9.6 0.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 2-Hacid_dh_C PF02826.19 EFE40455.1 - 5e-52 175.8 0.0 7e-52 175.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFE40455.1 - 1.7e-16 60.1 0.0 3e-16 59.3 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFE40455.1 - 5.2e-08 33.2 0.0 8.3e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EFE40455.1 - 0.0014 19.2 0.0 0.0032 18.0 0.0 1.6 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EFE40455.1 - 0.046 13.4 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA XdhC_C PF13478.6 EFE40455.1 - 0.051 14.1 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain WD40 PF00400.32 EFE40456.1 - 3.3e-39 132.2 19.5 1.7e-06 28.7 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE40456.1 - 1.2e-15 57.6 0.0 0.00052 20.3 0.1 4.7 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFE40456.1 - 0.00011 22.2 0.0 0.15 12.0 0.0 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EFE40456.1 - 0.00074 18.9 0.0 0.05 12.9 0.0 2.9 2 1 1 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 EFE40456.1 - 0.034 13.1 0.2 18 4.2 0.0 3.7 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EFE40456.1 - 0.13 10.8 0.0 0.92 8.0 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain YebO PF13974.6 EFE40458.1 - 0.039 14.0 0.3 0.072 13.2 0.3 1.6 1 0 0 1 1 1 0 YebO-like protein Conotoxin PF02950.17 EFE40458.1 - 0.052 14.6 0.1 0.19 12.7 0.1 2.1 1 0 0 1 1 1 0 Conotoxin AgrB PF04647.15 EFE40458.1 - 3.8 6.8 9.7 5.7 6.2 7.9 2.1 1 1 2 3 3 3 0 Accessory gene regulator B Choline_transpo PF04515.12 EFE40460.1 - 8.1 5.5 11.8 1.2 8.3 8.4 1.4 2 0 0 2 2 2 0 Plasma-membrane choline transporter CP2 PF04516.15 EFE40461.1 - 3.6e-77 258.7 0.1 5.8e-77 258.1 0.1 1.3 1 0 0 1 1 1 1 CP2 transcription factor MAAL_N PF05034.13 EFE40461.1 - 0.052 13.2 0.0 0.13 11.9 0.0 1.6 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase N-terminus Pkinase PF00069.25 EFE40463.1 - 5.2e-07 29.3 0.0 8e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFE40463.1 - 2.8e-05 24.2 0.0 6.8e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFE40463.1 - 0.00024 20.5 0.0 0.00056 19.3 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EFE40463.1 - 0.0038 16.5 0.0 0.011 15.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EFE40463.1 - 0.024 14.2 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase TFIIS_M PF07500.14 EFE40467.1 - 4.4e-29 101.2 1.8 4.4e-29 101.2 1.8 1.9 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EFE40467.1 - 1.8e-18 66.1 4.7 3e-18 65.4 4.7 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EFE40467.1 - 5.4e-13 48.7 0.5 1.2e-12 47.6 0.5 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain MLD PF11647.8 EFE40467.1 - 0.049 13.9 0.2 4.7 7.6 0.1 2.4 2 0 0 2 2 2 0 Membrane Localization Domain Baculo_LEF5_C PF11792.8 EFE40467.1 - 0.092 12.4 0.1 0.092 12.4 0.1 2.0 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain zf-LITAF-like PF10601.9 EFE40467.1 - 0.2 12.0 1.9 0.39 11.0 1.9 1.4 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain Sec10 PF07393.11 EFE40469.1 - 4.7e-235 782.3 0.0 5.5e-235 782.1 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 MarR_2 PF12802.7 EFE40469.1 - 0.12 12.3 0.3 2.2 8.3 0.0 2.9 3 0 0 3 3 3 0 MarR family MBOAT_2 PF13813.6 EFE40470.1 - 1.5e-16 60.4 0.2 4e-16 59.0 0.2 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family LRR_6 PF13516.6 EFE40471.1 - 9.3e-11 40.9 3.0 0.02 14.9 0.0 7.3 8 0 0 8 8 8 1 Leucine Rich repeat LRR_4 PF12799.7 EFE40471.1 - 3.5e-07 30.4 3.9 1.6 9.3 0.0 5.6 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFE40471.1 - 0.021 15.3 7.3 59 4.8 0.1 6.3 7 0 0 7 7 6 0 Leucine Rich Repeat BPL_N PF09825.9 EFE40471.1 - 0.44 9.6 4.1 0.67 9.0 4.1 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Drc1-Sld2 PF11719.8 EFE40471.1 - 0.93 9.0 14.7 1.3 8.5 14.7 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein Nop14 PF04147.12 EFE40471.1 - 1.3 7.2 24.9 1.6 6.8 24.9 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EFE40471.1 - 4.2 6.6 15.4 6.2 6.0 15.4 1.2 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 EFE40471.1 - 4.3 6.0 5.4 5.3 5.7 5.4 1.1 1 0 0 1 1 1 0 Presenilin SDA1 PF05285.12 EFE40471.1 - 6.7 6.0 26.9 9.4 5.5 26.9 1.2 1 0 0 1 1 1 0 SDA1 RNA_pol_Rpc4 PF05132.14 EFE40471.1 - 8.5 6.8 6.4 14 6.0 6.4 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Paf1 PF03985.13 EFE40471.1 - 9.4 5.1 24.0 13 4.7 24.0 1.1 1 0 0 1 1 1 0 Paf1 Alg6_Alg8 PF03155.15 EFE40472.1 - 1.6e-128 429.7 17.2 3.5e-80 270.3 4.7 2.0 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family RRM_1 PF00076.22 EFE40473.1 - 2.9e-31 107.1 0.1 2.8e-19 68.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFE40473.1 - 0.0014 18.7 0.0 0.95 9.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif NMT1 PF09084.11 EFE40476.1 - 2.6e-79 266.2 0.0 3.3e-79 265.8 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 EFE40476.1 - 1.4e-05 24.9 0.0 0.52 10.0 0.0 3.1 3 0 0 3 3 3 2 NMT1-like family Ribosomal_L37 PF08561.10 EFE40477.1 - 1.8e-44 151.1 4.0 1.8e-44 151.1 4.0 1.4 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L37 Spectrin PF00435.21 EFE40477.1 - 0.088 13.3 0.2 0.13 12.8 0.2 1.3 1 0 0 1 1 1 0 Spectrin repeat PGA2 PF07543.12 EFE40477.1 - 3.7 7.5 6.5 4.4 7.3 0.9 2.2 1 1 1 2 2 2 0 Protein trafficking PGA2 Beta-APP PF03494.13 EFE40478.1 - 0.21 11.5 0.7 0.33 10.8 0.7 1.3 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) Cpn60_TCP1 PF00118.24 EFE40479.1 - 1.3e-128 429.7 11.7 1.5e-128 429.6 11.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AAA PF00004.29 EFE40480.1 - 6.1e-41 139.9 0.0 1.1e-40 139.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE40480.1 - 3.3e-05 23.6 0.0 7.8e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EFE40480.1 - 7.2e-05 23.1 0.0 0.0073 16.6 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EFE40480.1 - 0.00011 22.2 0.1 0.00043 20.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFE40480.1 - 0.00021 21.4 0.0 0.00069 19.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFE40480.1 - 0.00031 21.2 0.1 0.0076 16.7 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EFE40480.1 - 0.0023 17.1 0.0 0.0042 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EFE40480.1 - 0.0083 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EFE40480.1 - 0.016 15.4 0.1 0.063 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFE40480.1 - 0.048 13.2 0.0 0.16 11.4 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EFE40480.1 - 0.051 13.7 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFE40480.1 - 0.062 13.7 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EFE40480.1 - 0.068 12.9 0.1 0.6 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EFE40480.1 - 0.089 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFE40480.1 - 0.095 12.4 0.0 0.24 11.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFE40480.1 - 0.12 13.0 0.0 0.49 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EFE40480.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain FAD_binding_2 PF00890.24 EFE40481.1 - 1.3e-124 416.5 3.4 1.7e-124 416.1 3.4 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EFE40481.1 - 1.5e-43 147.9 1.4 2.2e-43 147.3 1.4 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 EFE40481.1 - 1.1e-05 24.8 1.0 0.014 14.5 2.1 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EFE40481.1 - 1.3e-05 24.6 0.4 0.0011 18.3 0.1 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFE40481.1 - 7.8e-05 22.0 0.2 0.055 12.7 0.0 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 EFE40481.1 - 0.0042 16.4 0.7 0.0085 15.4 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EFE40481.1 - 0.078 12.5 1.7 0.17 11.4 1.7 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EFE40481.1 - 0.3 9.7 1.4 0.94 8.1 0.7 2.1 2 0 0 2 2 2 0 HI0933-like protein DPPIV_N PF00930.21 EFE40482.1 - 1.4e-109 366.2 0.4 1.9e-109 365.7 0.4 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EFE40482.1 - 5.4e-56 189.4 4.3 5.4e-56 189.4 4.3 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EFE40482.1 - 1.2e-05 25.1 1.2 5.5e-05 22.9 0.5 2.2 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EFE40482.1 - 0.0015 18.3 0.5 0.0047 16.6 0.5 1.8 1 1 0 1 1 1 1 Putative esterase PBP1_TM PF14812.6 EFE40482.1 - 0.032 14.6 0.0 0.095 13.1 0.0 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AXE1 PF05448.12 EFE40482.1 - 0.054 12.2 0.0 0.32 9.6 0.0 2.0 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 EFE40482.1 - 0.18 11.6 0.2 20 4.9 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase HNH_2 PF13391.6 EFE40483.1 - 1.6e-13 50.6 0.1 3.3e-13 49.6 0.1 1.6 1 0 0 1 1 1 1 HNH endonuclease Glyco_hydro_18 PF00704.28 EFE40484.1 - 5.7e-40 138.0 1.1 8.6e-40 137.4 1.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EFE40484.1 - 9.1e-09 35.2 0.0 2.9e-06 27.2 0.1 2.5 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 EFE40484.1 - 3.8e-05 24.1 8.5 3.8e-05 24.1 8.5 3.7 5 0 0 5 5 5 1 Chitin recognition protein HNH_2 PF13391.6 EFE40487.1 - 6.2e-09 35.9 0.0 1.8e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 HNH endonuclease DUF3246 PF11596.8 EFE40487.1 - 3.1 7.1 7.7 6.6 6.1 7.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) CoA_binding_3 PF13727.6 EFE40488.1 - 0.011 15.8 1.6 0.039 14.0 0.6 2.3 3 0 0 3 3 3 0 CoA-binding domain Ldh_1_C PF02866.18 EFE40489.1 - 9.2e-48 162.3 0.0 2e-47 161.2 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EFE40489.1 - 2.5e-39 134.6 0.0 4.1e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EFE40489.1 - 0.0006 18.9 0.0 0.00096 18.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EFE40489.1 - 0.066 12.8 0.0 0.34 10.4 0.2 2.0 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase AAA PF00004.29 EFE40490.1 - 9.2e-17 61.7 0.6 5.3e-16 59.2 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFE40490.1 - 0.00025 21.1 0.0 0.00079 19.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFE40490.1 - 0.0013 19.2 0.1 0.008 16.6 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFE40490.1 - 0.0035 17.6 2.5 0.014 15.7 0.1 2.8 2 1 1 3 3 3 1 AAA domain AAA_19 PF13245.6 EFE40490.1 - 0.023 15.0 0.0 0.086 13.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EFE40490.1 - 0.042 13.6 0.0 0.042 13.6 0.0 4.6 2 1 1 4 4 4 0 AAA domain AAA_33 PF13671.6 EFE40490.1 - 0.1 12.8 0.1 0.1 12.8 0.1 3.1 3 2 0 3 3 3 0 AAA domain Peptidase_S64 PF08192.11 EFE40490.1 - 5.6 5.3 33.4 12 4.2 33.4 1.6 1 0 0 1 1 1 0 Peptidase family S64 Myb_DNA-bind_6 PF13921.6 EFE40491.1 - 6.9e-05 23.0 0.3 0.043 14.1 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.7 EFE40491.1 - 0.0033 18.4 0.3 1.4 10.0 0.0 2.3 1 1 1 2 2 2 2 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EFE40491.1 - 0.032 14.6 2.3 0.079 13.3 0.2 2.2 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 EFE40491.1 - 0.12 12.5 2.2 1.5 9.0 0.1 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Peptidase_S64 PF08192.11 EFE40492.1 - 6.3e-08 31.6 0.0 9.5e-08 31.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S64 Trypsin_2 PF13365.6 EFE40492.1 - 0.015 16.2 0.0 0.037 14.9 0.0 1.7 1 1 0 1 1 1 0 Trypsin-like peptidase domain Peptidase_S7 PF00949.21 EFE40492.1 - 0.2 11.5 0.0 0.45 10.3 0.0 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease HbrB PF08539.11 EFE40494.1 - 2e-50 171.1 0.4 5.8e-50 169.6 0.0 2.1 2 0 0 2 2 2 1 HbrB-like UPF0239 PF06783.11 EFE40494.1 - 4.7 7.5 6.2 6.1 7.1 0.0 3.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0239) Ank_2 PF12796.7 EFE40495.1 - 1.5e-72 240.2 1.5 1.2e-16 61.1 0.3 6.3 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE40495.1 - 3.3e-63 209.3 3.9 3.7e-12 46.5 0.0 8.9 6 2 3 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE40495.1 - 8.6e-54 173.2 3.4 0.00091 19.5 0.0 13.5 13 0 0 13 13 13 12 Ankyrin repeat Ank_5 PF13857.6 EFE40495.1 - 6.3e-51 169.8 5.3 1.6e-07 31.4 0.1 12.1 2 1 11 13 13 13 13 Ankyrin repeats (many copies) Ank PF00023.30 EFE40495.1 - 3.8e-48 159.9 11.3 0.00011 22.5 0.0 12.7 13 0 0 13 13 13 11 Ankyrin repeat HNH_2 PF13391.6 EFE40496.1 - 3.6e-14 52.7 0.0 6e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease Gon7 PF08738.10 EFE40497.1 - 2.6e-14 53.2 0.9 4.7e-14 52.4 0.9 1.3 1 1 0 1 1 1 1 Gon7 family Vps39_1 PF10366.9 EFE40498.1 - 1.9e-29 102.1 0.0 2.6e-28 98.4 0.0 2.8 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 EFE40498.1 - 2.1e-21 76.4 0.1 1.3e-20 73.9 0.0 2.4 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EFE40498.1 - 9.2e-16 58.3 0.0 2.8e-15 56.6 0.0 1.7 1 1 0 1 1 1 1 CNH domain TPR_1 PF00515.28 EFE40498.1 - 0.098 12.5 0.1 35 4.4 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Clathrin PF00637.20 EFE40498.1 - 0.14 12.0 0.9 1.3 8.9 0.3 2.9 3 0 0 3 3 3 0 Region in Clathrin and VPS 6PF2K PF01591.18 EFE40499.1 - 5.3e-70 235.2 0.3 1.5e-69 233.7 0.3 1.6 1 1 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EFE40499.1 - 1.1e-40 139.4 0.0 1.7e-40 138.8 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EFE40499.1 - 6.5e-05 23.1 0.0 0.00014 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain APH PF01636.23 EFE40501.1 - 1.7e-17 64.2 0.0 2.3e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE40501.1 - 4.8e-05 23.1 0.0 7.7e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 EFE40501.1 - 0.0033 16.7 0.0 0.0084 15.3 0.0 1.6 2 0 0 2 2 2 1 Fructosamine kinase RIO1 PF01163.22 EFE40501.1 - 0.2 11.2 0.0 2.2 7.8 0.0 2.1 2 0 0 2 2 2 0 RIO1 family AA_permease PF00324.21 EFE40502.1 - 6e-130 434.0 39.9 6.7e-130 433.9 39.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE40502.1 - 1e-36 126.7 42.6 1.2e-36 126.5 42.6 1.0 1 0 0 1 1 1 1 Amino acid permease RdRP PF05183.12 EFE40503.1 - 3.4e-195 650.1 0.0 4.5e-195 649.7 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase RRM_1 PF00076.22 EFE40503.1 - 0.011 15.5 0.0 0.035 13.9 0.0 1.9 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ELP6 PF09807.9 EFE40504.1 - 0.026 13.9 0.0 0.049 13.0 0.0 1.4 1 0 0 1 1 1 0 Elongation complex protein 6 Slu7 PF11708.8 EFE40505.1 - 8.3e-84 281.5 18.2 8.3e-84 281.5 18.2 2.3 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 EFE40505.1 - 0.02 14.6 0.5 0.042 13.6 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EFE40505.1 - 0.3 11.3 2.8 0.57 10.4 2.8 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 EFE40505.1 - 1.2 8.9 4.5 2.6 7.8 4.5 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger DNA_pol_B PF00136.21 EFE40506.1 - 3e-101 339.4 0.0 4.6e-101 338.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFE40506.1 - 8.3e-15 54.8 0.0 1.3e-11 44.3 0.0 2.8 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain DUF1744 PF08490.12 EFE40506.1 - 0.015 13.9 0.0 0.025 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) Ran-binding PF05508.11 EFE40507.1 - 1.3e-109 366.0 0.0 1.9e-109 365.4 0.0 1.2 1 0 0 1 1 1 1 RanGTP-binding protein CTP_transf_like PF01467.26 EFE40508.1 - 8.2e-25 87.7 0.0 1.2e-24 87.1 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like GTP_EFTU PF00009.27 EFE40509.1 - 2.1e-40 138.4 0.0 3e-40 137.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFE40509.1 - 5.3e-30 104.0 0.1 1.2e-29 102.9 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFE40509.1 - 9.2e-10 38.8 0.4 2e-09 37.7 0.4 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFE40509.1 - 0.062 13.4 0.0 0.19 11.8 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase SRP-alpha_N PF04086.13 EFE40509.1 - 3.5 7.5 11.0 7.3 6.4 11.0 1.5 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TFIIA PF03153.13 EFE40509.1 - 7.7 6.4 25.0 12 5.8 25.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Aminotran_1_2 PF00155.21 EFE40510.1 - 9.5e-40 136.9 0.0 1.2e-39 136.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFE40510.1 - 0.039 12.9 0.0 1.6 7.6 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EFE40510.1 - 0.13 10.8 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_3 PF00202.21 EFE40511.1 - 9.1e-40 136.5 0.0 8.4e-38 130.1 0.0 2.3 1 1 0 1 1 1 1 Aminotransferase class-III AAA_26 PF13500.6 EFE40511.1 - 1.5e-18 67.3 0.0 3.5e-18 66.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain BATS PF06968.13 EFE40512.1 - 5.5e-22 77.7 0.1 2e-21 75.9 0.0 2.0 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EFE40512.1 - 6.7e-15 55.9 0.1 1.5e-14 54.7 0.1 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Oxidored_FMN PF00724.20 EFE40513.1 - 1.1e-56 192.5 0.0 1.5e-56 192.2 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF3223 PF11523.8 EFE40514.1 - 0.032 15.1 0.0 5.5 7.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3223) Glyco_hydro_108 PF05838.12 EFE40515.1 - 0.091 13.2 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase 108 GST_N PF02798.20 EFE40516.1 - 1.9e-10 40.9 0.0 4.1e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE40516.1 - 8.4e-10 38.8 0.0 2e-09 37.6 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFE40516.1 - 3.8e-09 36.8 0.0 6e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFE40516.1 - 1.3e-08 34.9 0.1 3.8e-08 33.4 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFE40516.1 - 1.6e-06 28.3 0.1 4.9e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE40516.1 - 0.00036 20.5 0.2 0.00077 19.4 0.2 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TYW3 PF02676.14 EFE40516.1 - 0.096 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase TYW3 FAA_hydrolase PF01557.18 EFE40517.1 - 7.7e-55 185.9 0.0 1e-54 185.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EFE40517.1 - 5.2e-32 110.2 0.0 8.7e-32 109.5 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal HgmA PF04209.13 EFE40519.1 - 1.3e-198 660.0 0.0 7.4e-198 657.5 0.0 1.8 1 1 0 1 1 1 1 homogentisate 1,2-dioxygenase TPR_17 PF13431.6 EFE40520.1 - 0.00048 20.3 0.1 0.035 14.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Glyoxalase PF00903.25 EFE40521.1 - 1.4e-24 86.7 0.9 1.9e-17 63.6 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFE40521.1 - 1.7e-14 54.0 0.2 6.5e-07 29.6 0.2 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EFE40521.1 - 1.3e-07 31.9 0.1 0.00082 19.5 0.2 2.7 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 EFE40521.1 - 0.00097 19.3 0.2 0.014 15.6 0.2 2.4 1 1 0 1 1 1 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal DUF4844 PF16133.5 EFE40521.1 - 0.032 14.8 0.0 0.15 12.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4844) COX15-CtaA PF02628.15 EFE40522.1 - 4.3e-114 380.9 6.1 5.2e-114 380.7 6.1 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Prok-RING_2 PF14445.6 EFE40523.1 - 0.17 12.1 5.9 0.33 11.2 5.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 zf-RING_4 PF14570.6 EFE40523.1 - 0.29 11.0 4.2 0.56 10.0 4.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RanBP PF00641.18 EFE40523.1 - 0.81 9.1 10.6 0.019 14.3 4.2 1.7 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others tRNA-synt_2 PF00152.20 EFE40524.1 - 3.4e-78 262.9 0.3 4.6e-78 262.5 0.3 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFE40524.1 - 2.6e-12 46.6 0.0 6.9e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFE40524.1 - 1.3e-05 24.9 0.1 0.018 14.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Dynamin_N PF00350.23 EFE40525.1 - 3.5e-23 82.5 0.0 1.5e-22 80.4 0.0 2.0 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFE40525.1 - 1.1e-18 67.5 0.0 3.1e-14 52.9 0.0 2.2 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EFE40525.1 - 0.0012 18.9 0.0 0.018 15.1 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFE40525.1 - 0.012 15.8 0.0 0.05 13.8 0.1 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF4287 PF14117.6 EFE40525.1 - 0.091 12.9 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) Ras PF00071.22 EFE40525.1 - 0.15 11.6 0.1 0.32 10.6 0.1 1.5 1 0 0 1 1 1 0 Ras family NTP_transferase PF00483.23 EFE40526.1 - 3.7e-31 108.6 0.0 4.9e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EFE40526.1 - 1.1e-08 34.5 7.4 4.1e-06 26.3 0.1 3.5 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EFE40526.1 - 2e-08 34.8 0.0 3e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EFE40526.1 - 0.011 15.5 0.0 0.036 13.8 0.0 1.7 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep_2 PF14602.6 EFE40526.1 - 0.082 12.7 2.0 0.53 10.1 0.0 3.0 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase Bys1 PF04681.12 EFE40527.1 - 0.00036 20.5 0.1 0.00052 20.0 0.1 1.1 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Putative_PNPOx PF01243.20 EFE40529.1 - 2e-09 37.5 0.0 0.00018 21.6 0.0 2.9 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.24 EFE40529.1 - 3.5e-05 24.1 0.0 0.0028 18.0 0.0 2.7 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain zf-RING_2 PF13639.6 EFE40530.1 - 1.3e-08 35.0 3.6 2.1e-08 34.4 3.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EFE40530.1 - 4.3e-06 26.9 3.6 6.3e-05 23.2 3.6 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFE40530.1 - 0.00013 21.9 6.0 0.00022 21.2 6.0 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EFE40530.1 - 0.00048 20.1 0.4 0.00079 19.4 0.4 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EFE40530.1 - 0.012 15.4 3.7 0.079 12.8 3.6 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_9 PF14369.6 EFE40530.1 - 0.026 14.8 0.1 0.062 13.6 0.1 1.6 1 0 0 1 1 1 0 zinc-ribbon zf-RING_11 PF17123.5 EFE40530.1 - 0.038 13.7 3.8 0.072 12.9 3.8 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 EFE40530.1 - 0.061 13.2 1.4 0.24 11.3 1.3 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EFE40530.1 - 1.4 8.9 3.3 0.51 10.3 0.3 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Atx10homo_assoc PF09759.9 EFE40531.1 - 1.3e-32 111.8 1.7 1.5e-32 111.6 0.3 1.9 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Ribosomal_60s PF00428.19 EFE40531.1 - 4.2 8.0 5.2 65 4.2 0.1 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Rap1_C PF11626.8 EFE40532.1 - 4.9e-19 68.2 0.0 3.6e-18 65.4 0.0 2.2 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.11 EFE40532.1 - 3.2e-08 33.6 0.4 1.5e-07 31.4 0.0 2.4 3 0 0 3 3 3 1 Rap1 Myb domain BRCT_2 PF16589.5 EFE40532.1 - 3e-06 27.6 0.0 6.7e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFE40532.1 - 0.0096 16.3 0.0 0.027 14.9 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EFE40532.1 - 0.029 14.7 0.1 0.23 11.8 0.0 2.4 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain Rap1-DNA-bind PF09197.10 EFE40532.1 - 0.085 13.5 0.8 0.41 11.3 0.8 2.2 1 1 0 1 1 1 0 Rap1, DNA-binding Chromo_shadow PF01393.19 EFE40533.1 - 8.9e-11 41.7 0.0 1.3e-08 34.8 0.0 2.3 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 EFE40533.1 - 4.1e-09 36.2 0.0 9.2e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Cytomega_UL84 PF06284.11 EFE40533.1 - 4.2 5.7 5.5 5.9 5.2 5.5 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DNA_pol_phi PF04931.13 EFE40533.1 - 5.7 4.9 13.8 6.8 4.7 13.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi Cpn60_TCP1 PF00118.24 EFE40534.1 - 1.1e-126 423.4 4.6 2.3e-126 422.3 4.6 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family ESR1_C PF12743.7 EFE40536.1 - 0.087 12.6 0.1 0.087 12.6 0.1 1.2 1 0 0 1 1 1 0 Oestrogen-type nuclear receptor final C-terminal ETRAMP PF09716.10 EFE40536.1 - 0.11 12.5 0.9 0.12 12.5 0.9 1.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Wbp11 PF09429.10 EFE40537.1 - 2.4e-20 72.7 16.1 2.4e-20 72.7 16.1 2.1 3 0 0 3 3 3 1 WW domain binding protein 11 GHMP_kinases_C PF08544.13 EFE40537.1 - 0.04 14.3 2.5 3.2 8.2 0.1 2.6 2 0 0 2 2 2 0 GHMP kinases C terminal Nkap_C PF06047.11 EFE40537.1 - 0.045 13.9 3.1 0.077 13.1 0.1 2.5 2 0 0 2 2 2 0 NF-kappa-B-activating protein C-terminal domain Pkinase PF00069.25 EFE40538.1 - 4.1e-55 187.0 0.0 1.1e-33 116.7 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40538.1 - 8e-36 123.6 0.0 7.5e-35 120.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE40538.1 - 0.0061 15.4 0.6 0.071 11.9 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase DUF3896 PF13035.6 EFE40538.1 - 2.9 8.1 7.1 0.32 11.2 0.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3896) ALMT PF11744.8 EFE40538.1 - 3.7 6.3 5.8 6.8 5.4 5.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter BTB PF00651.31 EFE40539.1 - 7.1e-14 52.0 1.4 1.5e-13 51.0 0.2 2.1 3 0 0 3 3 3 1 BTB/POZ domain TRP PF06011.12 EFE40540.1 - 2.8e-77 260.3 20.9 4.2e-77 259.7 20.9 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EFE40540.1 - 3.5e-27 95.5 0.0 2.9e-25 89.3 0.0 2.4 1 1 0 1 1 1 1 ML-like domain PIG-F PF06699.11 EFE40540.1 - 0.0089 16.2 1.3 0.0089 16.2 1.3 3.2 4 0 0 4 4 4 1 GPI biosynthesis protein family Pig-F DUF4501 PF14946.6 EFE40540.1 - 8.6 6.4 8.0 1.1 9.2 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4501) PRANC PF09372.10 EFE40541.1 - 0.0066 16.8 0.0 0.0077 16.5 0.0 1.1 1 0 0 1 1 1 1 PRANC domain F-box PF00646.33 EFE40541.1 - 0.0071 16.2 0.0 0.0096 15.8 0.0 1.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE40541.1 - 0.023 14.6 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 F-box-like ThrE PF06738.12 EFE40544.1 - 2.9e-66 223.3 10.5 6.7e-62 209.0 0.5 2.4 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EFE40544.1 - 5.5e-09 36.3 11.7 5.5e-09 36.3 11.7 3.1 3 0 0 3 3 3 2 Threonine/Serine exporter, ThrE PS_Dcarbxylase PF02666.15 EFE40546.1 - 1.4e-54 184.7 0.0 2.4e-54 184.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EFE40546.1 - 3.5e-37 126.8 0.0 7.8e-18 64.7 0.0 2.7 2 0 0 2 2 2 2 C2 domain EF-hand_5 PF13202.6 EFE40546.1 - 0.0082 15.6 0.0 0.022 14.3 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 EFE40546.1 - 0.035 13.7 0.0 0.11 12.1 0.0 1.9 1 0 0 1 1 1 0 EF hand Presenilin PF01080.17 EFE40548.1 - 0.49 9.1 12.0 0.58 8.9 12.0 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 EFE40548.1 - 2.5 7.0 10.5 2.9 6.8 10.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 EFE40548.1 - 3.2 7.5 15.5 4 7.2 15.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MDM10 PF12519.8 EFE40548.1 - 4.8 5.9 6.6 5.8 5.7 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4551 PF15087.6 EFE40548.1 - 8.6 5.1 12.4 9.9 4.9 12.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) p450 PF00067.22 EFE40549.1 - 3.4e-26 92.0 0.0 4.8e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EFE40550.1 - 1.4e-23 83.4 45.4 2.3e-23 82.7 42.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily FPN1 PF06963.12 EFE40550.1 - 0.041 12.4 4.8 0.094 11.3 3.1 2.1 1 1 1 2 2 2 0 Ferroportin1 (FPN1) Fungal_trans PF04082.18 EFE40552.1 - 1.5e-06 27.5 0.1 0.0087 15.1 0.0 2.4 1 1 1 2 2 2 2 Fungal specific transcription factor domain Trp_DMAT PF11991.8 EFE40553.1 - 4e-106 355.5 0.0 4.5e-106 355.3 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase AMP-binding PF00501.28 EFE40554.1 - 6.3e-119 397.3 0.0 1.9e-59 201.3 0.0 3.2 2 1 1 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EFE40554.1 - 1.4e-94 317.3 0.0 4e-52 177.4 0.0 2.1 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EFE40554.1 - 4.8e-24 84.5 0.0 1.4e-09 38.2 0.0 3.9 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE40554.1 - 1.5e-10 41.9 0.0 0.00056 20.8 0.0 2.6 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Transferase PF02458.15 EFE40554.1 - 0.11 11.1 0.0 0.24 10.0 0.0 1.4 1 0 0 1 1 1 0 Transferase family Methyltransf_2 PF00891.18 EFE40555.1 - 1.5e-29 102.9 0.0 2e-29 102.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFE40555.1 - 0.00088 19.2 0.2 0.0029 17.6 0.1 1.8 2 0 0 2 2 2 1 Dimerisation domain DIT1_PvcA PF05141.12 EFE40556.1 - 1.8e-92 309.7 0.0 2.9e-92 309.1 0.0 1.3 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein AMP-binding PF00501.28 EFE40556.1 - 1.5e-23 83.1 0.0 2.3e-23 82.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Transferase PF02458.15 EFE40556.1 - 6.3e-12 44.9 0.0 4.9e-11 41.9 0.0 2.2 1 1 0 1 1 1 1 Transferase family PP-binding PF00550.25 EFE40556.1 - 7.5e-08 32.6 0.0 1.8e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site MFS_1 PF07690.16 EFE40557.1 - 1.9e-16 59.9 58.2 1.1e-11 44.3 35.8 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF3836 PF12930.7 EFE40557.1 - 0.14 11.9 0.1 0.37 10.5 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF3836) MFS_1 PF07690.16 EFE40558.1 - 7.5e-15 54.7 68.1 6.1e-13 48.4 62.1 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE40558.1 - 1.4e-05 23.8 25.4 1.9e-05 23.3 25.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) WSC PF01822.19 EFE40559.1 - 4.6e-42 142.1 43.1 6.3e-18 64.7 10.7 3.4 3 0 0 3 3 3 3 WSC domain Glyoxal_oxid_N PF07250.11 EFE40559.1 - 1.2e-24 86.8 0.0 6.5e-24 84.5 0.0 2.1 3 0 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EFE40559.1 - 6.7e-20 71.2 0.0 1.6e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_2 PF07646.15 EFE40559.1 - 0.032 14.2 0.0 0.45 10.6 0.0 3.1 2 0 0 2 2 2 0 Kelch motif E1-E2_ATPase PF00122.20 EFE40560.1 - 5.8e-48 162.8 5.0 5.8e-48 162.8 5.0 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 EFE40560.1 - 1e-11 44.3 0.6 4.9e-11 42.2 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EFE40560.1 - 5.1e-07 30.2 0.0 2.8e-06 27.8 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE40560.1 - 0.0015 18.6 0.0 0.0031 17.6 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) DUF4392 PF14336.6 EFE40560.1 - 0.091 12.2 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) O-antigen_lig PF13425.6 EFE40560.1 - 0.17 10.6 5.6 0.32 9.7 5.6 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein GET2 PF08690.10 EFE40560.1 - 7.7 6.1 7.0 14 5.2 7.0 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 RRM_1 PF00076.22 EFE40561.1 - 2.5e-07 30.4 0.0 4.4e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GET2 PF08690.10 EFE40561.1 - 0.69 9.5 4.5 1.2 8.8 4.5 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 TFIIA PF03153.13 EFE40561.1 - 1.6 8.6 18.0 2.4 8.1 18.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CTD_bind PF04818.13 EFE40562.1 - 0.0048 17.7 0.0 0.0087 16.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II-binding domain. DSPc PF00782.20 EFE40563.1 - 1.4e-19 70.3 0.0 5.8e-16 58.5 0.0 2.1 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFE40563.1 - 0.01 15.4 2.1 0.014 15.0 0.1 2.1 1 1 1 2 2 2 0 Protein-tyrosine phosphatase Citrate_synt PF00285.21 EFE40564.1 - 1.4e-94 317.2 0.0 4.5e-86 289.2 0.0 2.1 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Doppel PF11466.8 EFE40565.1 - 0.063 12.9 1.4 0.68 9.6 0.5 2.5 2 0 0 2 2 2 0 Prion-like protein Doppel Mito_carr PF00153.27 EFE40568.1 - 2.2e-25 88.4 7.3 7.9e-12 44.9 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Peptidase_M16 PF00675.20 EFE40569.1 - 1.3e-17 64.1 0.0 2.4e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFE40569.1 - 1.1e-12 48.3 0.0 2.1e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain RNA_pol_Rpc82 PF05645.13 EFE40570.1 - 4.4e-39 134.8 4.9 2.3e-35 122.6 0.0 3.1 2 2 1 3 3 3 3 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EFE40570.1 - 2e-16 59.8 2.1 3.2e-09 36.7 0.1 3.8 4 0 0 4 4 4 3 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EFE40570.1 - 4.2e-07 29.8 0.2 4.8e-06 26.4 0.1 2.6 2 0 0 2 2 2 1 TFIIE alpha subunit CENP-B_dimeris PF09026.10 EFE40570.1 - 0.065 13.6 9.3 0.09 13.2 0.3 3.7 4 0 0 4 4 4 0 Centromere protein B dimerisation domain Sec8_exocyst PF04048.14 EFE40571.1 - 2.5e-40 137.6 0.7 2.5e-40 137.6 0.7 2.3 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EFE40571.1 - 4e-07 29.6 1.2 8.4e-07 28.6 1.2 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 EFE40571.1 - 0.26 11.4 3.2 0.17 12.0 0.5 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Tannase PF07519.11 EFE40574.1 - 7.5e-98 328.5 0.1 8.7e-98 328.2 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EFE40574.1 - 5.4e-06 26.0 0.0 0.06 12.8 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFE40574.1 - 0.0051 16.1 0.0 0.25 10.6 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Aldo_ket_red PF00248.21 EFE40575.1 - 2.1e-27 96.1 0.0 7.3e-18 64.8 0.0 2.2 1 1 1 2 2 2 2 Aldo/keto reductase family Rit1_C PF17184.4 EFE40576.1 - 2.7e-45 155.0 0.0 4.6e-45 154.2 0.0 1.4 2 0 0 2 2 2 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EFE40576.1 - 9e-17 61.4 0.0 1.9e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain Rit1_C PF17184.4 EFE40577.1 - 5.3e-37 127.7 0.0 6e-37 127.6 0.0 1.0 1 0 0 1 1 1 1 Rit1 N-terminal domain HAD_2 PF13419.6 EFE40579.1 - 8.4e-19 68.3 0.0 1.1e-18 68.0 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase NIF PF03031.18 EFE40579.1 - 1.7e-06 27.9 0.0 3.6e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase PF00702.26 EFE40579.1 - 3.3e-05 24.3 0.1 0.00023 21.5 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE40579.1 - 0.0016 18.5 0.0 0.0027 17.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DUF4853 PF16145.5 EFE40579.1 - 0.072 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) Glycos_transf_3 PF00591.21 EFE40580.1 - 4.7e-55 186.9 0.0 4.9e-46 157.4 0.1 2.2 1 1 1 2 2 2 2 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EFE40580.1 - 3e-06 27.0 1.3 4e-06 26.6 0.3 1.7 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain fn3 PF00041.21 EFE40581.1 - 1.1e-11 44.9 3.8 2e-06 28.1 0.0 4.4 4 1 0 4 4 4 2 Fibronectin type III domain Lipase_GDSL_2 PF13472.6 EFE40581.1 - 5.7e-11 43.1 0.3 2.3e-09 37.9 0.3 2.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFE40581.1 - 0.064 13.2 0.0 0.25 11.3 0.0 1.9 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Fe_hyd_lg_C PF02906.14 EFE40583.1 - 1.1e-50 172.6 0.0 2.2e-50 171.6 0.0 1.5 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain DUF2263 PF10021.9 EFE40584.1 - 4.3e-19 69.3 0.0 1.4e-18 67.6 0.0 1.9 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Fapy_DNA_glyco PF01149.24 EFE40585.1 - 3.1e-34 118.0 0.0 5.1e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EFE40585.1 - 5.1e-08 32.8 0.0 2e-06 27.7 0.0 2.4 1 1 1 2 2 2 1 Formamidopyrimidine-DNA glycosylase H2TH domain Mitofilin PF09731.9 EFE40585.1 - 0.026 13.4 6.8 0.035 13.0 6.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Pol_alpha_B_N PF08418.10 EFE40585.1 - 0.17 11.8 13.6 0.23 11.4 13.6 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal RR_TM4-6 PF06459.12 EFE40585.1 - 0.57 10.0 3.6 0.85 9.4 3.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.8 EFE40586.1 - 4.2e-215 715.5 3.1 4.2e-215 715.5 3.1 1.8 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_14 PF13428.6 EFE40586.1 - 1.8e-21 75.0 14.2 0.0012 19.5 1.6 9.8 8 2 2 10 10 10 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFE40586.1 - 8.4e-19 66.1 29.3 9.1e-05 22.3 0.5 9.9 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFE40586.1 - 4.4e-16 59.1 22.9 0.00017 22.0 0.0 6.9 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 EFE40586.1 - 2e-11 44.3 15.7 0.0018 18.9 1.2 7.6 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFE40586.1 - 4.6e-11 42.0 22.7 0.0003 20.8 0.3 7.9 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFE40586.1 - 5.4e-11 42.0 11.9 0.00038 20.1 1.4 6.2 6 0 0 6 6 6 2 TPR repeat TPR_1 PF00515.28 EFE40586.1 - 1.4e-10 40.5 29.9 1.4e-05 24.7 0.6 8.4 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_9 PF13371.6 EFE40586.1 - 2.2e-09 37.3 13.1 0.0038 17.4 0.0 5.9 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFE40586.1 - 8.6e-08 32.4 20.9 0.068 13.5 0.5 7.2 6 1 0 6 6 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE40586.1 - 9.2e-07 29.0 9.2 0.063 13.5 1.1 4.7 4 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 EFE40586.1 - 1.1e-06 28.4 1.2 8.6e-05 22.3 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat-like domain TPR_17 PF13431.6 EFE40586.1 - 7.9e-06 25.9 14.2 0.073 13.5 0.0 6.9 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFE40586.1 - 2.4e-05 23.7 14.9 0.0054 16.0 0.8 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat BTAD PF03704.17 EFE40586.1 - 0.00057 20.3 2.4 0.0037 17.7 0.2 3.0 2 0 0 2 2 2 1 Bacterial transcriptional activator domain TPR_6 PF13174.6 EFE40586.1 - 0.00071 20.0 17.8 0.15 12.8 0.2 6.9 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFE40586.1 - 0.00094 19.1 14.1 0.95 9.6 0.4 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_3 PF07720.12 EFE40586.1 - 0.0025 17.7 5.6 0.056 13.5 0.2 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat Rapsyn_N PF10579.9 EFE40586.1 - 0.099 12.8 0.1 0.39 10.9 0.1 2.1 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region TPR_4 PF07721.14 EFE40586.1 - 0.13 13.0 11.1 3.7 8.5 2.1 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat ATP-synt_Eps PF04627.13 EFE40586.1 - 0.46 10.5 0.0 0.46 10.5 0.0 2.4 2 0 0 2 2 1 0 Mitochondrial ATP synthase epsilon chain Fis1_TPR_C PF14853.6 EFE40586.1 - 0.91 9.6 8.9 36 4.5 0.2 5.0 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Tim54 PF11711.8 EFE40587.1 - 1.3e-135 452.0 0.0 1.6e-135 451.7 0.0 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 SPX PF03105.19 EFE40587.1 - 0.28 11.1 4.6 0.46 10.3 4.6 1.3 1 0 0 1 1 1 0 SPX domain Pkinase PF00069.25 EFE40588.1 - 4.6e-56 190.1 0.0 7.9e-55 186.1 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40588.1 - 1.2e-24 87.0 0.3 5.3e-19 68.5 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFE40588.1 - 4.3e-06 25.9 0.1 6.3e-06 25.4 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFE40588.1 - 0.0007 19.0 0.2 0.0018 17.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFE40588.1 - 0.0016 17.9 0.0 0.0038 16.6 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE40588.1 - 0.0078 16.2 5.6 0.039 13.9 0.2 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family NFACT-C PF11923.8 EFE40588.1 - 0.032 14.1 0.4 0.067 13.1 0.4 1.5 1 0 0 1 1 1 0 NFACT protein C-terminal domain Pkinase_fungal PF17667.1 EFE40588.1 - 0.041 12.6 0.0 0.074 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 EFE40588.1 - 0.048 12.7 0.0 0.078 12.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 PepX_N PF09168.10 EFE40588.1 - 0.063 13.7 0.7 0.14 12.6 0.7 1.5 1 0 0 1 1 1 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal Pox_ser-thr_kin PF05445.11 EFE40588.1 - 0.075 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 EFE40588.1 - 0.5 9.9 2.4 0.84 9.2 0.0 2.1 2 0 0 2 2 2 0 RIO1 family SF3A2 PF16835.5 EFE40589.1 - 3.3e-37 126.8 0.0 4.8e-37 126.2 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EFE40589.1 - 1.2e-05 25.5 0.5 2.1e-05 24.8 0.5 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PRP4 PF08799.11 EFE40589.1 - 0.05 13.2 1.5 0.11 12.0 1.5 1.6 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Methyltransf_11 PF08241.12 EFE40590.1 - 1.6e-12 47.9 0.0 3.5e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE40590.1 - 1.6e-10 41.6 0.0 4.4e-10 40.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE40590.1 - 9.1e-08 32.8 0.0 1.8e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE40590.1 - 0.00033 20.5 0.0 0.00055 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE40590.1 - 0.0017 18.2 0.0 0.0025 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFE40590.1 - 0.085 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.18 EFE40591.1 - 1.7e-05 24.2 0.0 1.9e-05 24.1 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase domain MFS_1 PF07690.16 EFE40592.1 - 1.4e-40 139.4 32.4 1.4e-40 139.4 32.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE40592.1 - 1.9e-11 43.5 11.9 1.9e-11 43.5 11.9 2.9 3 0 0 3 3 3 1 Sugar (and other) transporter CAP_GLY PF01302.25 EFE40593.1 - 1.4e-19 69.9 0.1 2.4e-19 69.1 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EFE40593.1 - 1.7e-11 44.1 6.6 0.0025 18.2 0.0 4.4 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFE40593.1 - 0.00015 21.3 5.6 0.093 12.2 0.1 3.4 2 1 0 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 EFE40593.1 - 0.00018 21.3 2.8 4.6 7.5 0.0 4.8 5 0 0 5 5 5 2 Leucine Rich repeat LRR_8 PF13855.6 EFE40593.1 - 0.0014 18.4 14.7 0.015 15.0 1.2 4.5 4 2 1 5 5 5 2 Leucine rich repeat Trnau1ap PF17654.1 EFE40593.1 - 0.031 15.1 0.5 0.074 13.9 0.5 1.6 1 0 0 1 1 1 0 Selenocysteine tRNA 1 associated proteins LRR_1 PF00560.33 EFE40593.1 - 0.25 12.0 7.3 24 6.0 0.0 5.5 6 0 0 6 6 6 0 Leucine Rich Repeat zf-U1 PF06220.12 EFE40594.1 - 5.9e-08 32.3 0.5 1.1e-07 31.5 0.5 1.5 1 0 0 1 1 1 1 U1 zinc finger ABC_tran_Xtn PF12848.7 EFE40594.1 - 1.1 9.3 12.2 0.34 11.0 0.5 2.8 3 1 0 3 3 3 0 ABC transporter 2-Hacid_dh_C PF02826.19 EFE40596.1 - 4.1e-54 182.7 0.0 7.6e-54 181.8 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EFE40596.1 - 0.021 15.0 0.0 0.027 14.6 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase CwfJ_C_1 PF04677.15 EFE40597.1 - 2.1e-29 101.9 0.0 3.7e-29 101.1 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EFE40597.1 - 7.5e-29 100.5 0.1 7.5e-29 100.5 0.1 2.3 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 FumaraseC_C PF10415.9 EFE40597.1 - 0.004 17.6 1.3 2.2 8.8 0.1 3.1 3 0 0 3 3 3 2 Fumarase C C-terminus ATP_bind_1 PF03029.17 EFE40598.1 - 1.9e-70 237.4 0.0 2.7e-70 236.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EFE40598.1 - 0.00018 21.1 0.0 0.012 15.1 0.0 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EFE40598.1 - 0.00057 19.0 0.0 0.1 11.5 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EFE40598.1 - 0.001 18.8 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EFE40598.1 - 0.0011 18.6 0.0 0.031 13.9 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EFE40598.1 - 0.0015 18.6 0.0 0.021 14.9 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase PRK PF00485.18 EFE40598.1 - 0.0035 17.1 0.0 0.0096 15.7 0.0 1.7 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family Roc PF08477.13 EFE40598.1 - 0.0046 17.2 0.0 0.93 9.7 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 EFE40598.1 - 0.0055 16.6 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain FeoB_N PF02421.18 EFE40598.1 - 0.0056 16.2 0.0 0.11 12.0 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B cobW PF02492.19 EFE40598.1 - 0.0086 15.7 0.0 1.6 8.3 0.0 2.5 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EFE40598.1 - 0.0097 15.1 0.0 0.022 14.0 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain G-alpha PF00503.20 EFE40598.1 - 0.012 14.8 0.0 0.47 9.5 0.0 2.6 3 0 0 3 3 3 0 G-protein alpha subunit AAA_16 PF13191.6 EFE40598.1 - 0.014 15.8 0.0 0.039 14.3 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 EFE40598.1 - 0.018 15.2 0.0 0.04 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 EFE40598.1 - 0.023 14.2 0.0 2.7 7.4 0.0 2.9 3 0 0 3 3 3 0 ADP-ribosylation factor family CLP1_P PF16575.5 EFE40598.1 - 0.025 14.4 0.0 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 EFE40598.1 - 0.026 14.3 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFE40598.1 - 0.027 14.7 0.0 0.08 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFE40598.1 - 0.028 14.3 0.0 5.8 6.8 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase AAA_7 PF12775.7 EFE40598.1 - 0.034 13.7 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 EFE40598.1 - 0.61 10.6 5.0 1.3 9.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain GST_N_3 PF13417.6 EFE40599.1 - 6.6e-20 71.3 0.0 1.6e-19 70.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE40599.1 - 5.7e-16 58.6 0.0 1.8e-15 57.0 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFE40599.1 - 1.7e-07 31.5 0.0 3.4e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFE40599.1 - 3.7e-06 26.9 0.1 7.9e-06 25.8 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EFE40599.1 - 0.075 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin SUZ PF12752.7 EFE40600.1 - 1e-05 26.2 5.1 1e-05 26.2 5.1 4.0 3 2 0 3 3 3 1 SUZ domain Serglycin PF04360.12 EFE40601.1 - 0.56 10.1 3.8 0.36 10.8 1.1 1.9 2 0 0 2 2 2 0 Serglycin F-box-like PF12937.7 EFE40602.1 - 8.4e-05 22.4 0.2 0.00023 21.0 0.2 1.8 1 0 0 1 1 1 1 F-box-like DUF1772 PF08592.11 EFE40602.1 - 0.00015 22.1 0.2 0.0011 19.2 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1772) LRR_6 PF13516.6 EFE40602.1 - 0.0002 21.1 8.5 6.3 7.1 0.0 5.8 5 0 0 5 5 5 1 Leucine Rich repeat LRR_4 PF12799.7 EFE40602.1 - 0.0018 18.6 12.9 0.089 13.3 0.2 5.5 5 0 0 5 5 5 1 Leucine Rich repeats (2 copies) ELMO_CED12 PF04727.13 EFE40602.1 - 0.0038 17.4 0.1 0.0083 16.2 0.1 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family DUF4834 PF16118.5 EFE40602.1 - 0.0075 17.2 0.0 0.0075 17.2 0.0 4.0 3 1 0 3 3 2 1 Domain of unknown function (DUF4834) DUF1980 PF09323.10 EFE40602.1 - 0.0084 16.0 0.9 4.1 7.3 0.0 3.0 3 0 0 3 3 3 2 Domain of unknown function (DUF1980) Paf67 PF10255.9 EFE40602.1 - 0.017 14.1 0.3 0.028 13.4 0.3 1.3 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 LRR_1 PF00560.33 EFE40602.1 - 0.039 14.5 7.5 72 4.5 0.2 6.4 6 0 0 6 6 6 0 Leucine Rich Repeat DUF3328 PF11807.8 EFE40602.1 - 0.29 10.9 5.3 0.24 11.2 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) Peptidase_S49_N PF08496.10 EFE40602.1 - 0.64 10.1 3.2 2.1 8.4 0.0 2.9 3 0 0 3 3 3 0 Peptidase family S49 N-terminal F-box PF00646.33 EFE40602.1 - 1.2 9.1 9.3 0.29 11.1 1.1 3.2 2 1 0 2 2 2 0 F-box domain CCDC53 PF10152.9 EFE40602.1 - 7.5 7.0 13.3 2 8.8 1.9 3.3 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex DUF3761 PF12587.8 EFE40603.1 - 0.081 13.4 0.4 0.21 12.1 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) AA_permease_2 PF13520.6 EFE40605.1 - 5.4e-45 154.0 40.7 6.4e-45 153.7 40.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE40605.1 - 2.4e-17 62.7 37.8 3.1e-17 62.4 37.8 1.0 1 0 0 1 1 1 1 Amino acid permease DUF962 PF06127.11 EFE40605.1 - 0.034 14.2 5.3 1.4 9.0 0.1 3.6 2 2 0 2 2 2 0 Protein of unknown function (DUF962) p450 PF00067.22 EFE40606.1 - 3.2e-49 167.9 0.0 2.2e-48 165.2 0.0 2.2 1 1 0 1 1 1 1 Cytochrome P450 APH PF01636.23 EFE40607.1 - 1.1e-14 55.0 0.0 1.4e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE40607.1 - 9.6e-09 35.1 0.0 1.1e-07 31.7 0.0 2.1 1 1 0 1 1 1 1 Choline/ethanolamine kinase PH_TFIIH PF08567.11 EFE40608.1 - 4.4e-24 84.6 0.0 1.1e-23 83.4 0.0 1.7 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 EFE40608.1 - 5.5e-23 80.7 8.5 1.2e-11 44.4 1.0 3.0 3 0 0 3 3 3 2 BSD domain Anillin_N PF16018.5 EFE40608.1 - 0.089 13.4 0.5 8.2 7.1 0.0 2.9 2 0 0 2 2 2 0 Anillin N-terminus PIN_8 PF18476.1 EFE40608.1 - 1.3 8.9 7.1 0.13 12.1 0.2 2.6 3 0 0 3 3 3 0 PIN like domain PhoR PF11808.8 EFE40609.1 - 0.39 11.2 4.3 0.89 10.0 1.1 2.4 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR ING PF12998.7 EFE40610.1 - 1e-07 32.5 0.0 2.4e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EFE40610.1 - 0.00047 20.0 0.9 0.00084 19.2 0.9 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EFE40610.1 - 0.059 13.6 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain Transket_pyr PF02779.24 EFE40611.1 - 1.7e-66 223.3 0.0 2.8e-66 222.6 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EFE40611.1 - 1.5e-56 190.3 0.0 2.5e-56 189.6 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 EFE40611.1 - 3e-56 190.6 0.0 4.6e-56 190.0 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component 2-oxogl_dehyd_N PF16078.5 EFE40611.1 - 3.1e-20 71.5 0.6 3.1e-20 71.5 0.6 1.8 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus SHR-BD PF06650.12 EFE40612.1 - 1.6e-93 313.0 0.0 5.9e-92 307.9 0.0 3.1 3 1 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13 PF16908.5 EFE40612.1 - 7.6e-81 271.4 3.7 2.8e-79 266.2 0.0 4.5 5 0 0 5 5 5 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 EFE40612.1 - 4.6e-79 265.2 10.8 9.5e-73 244.5 0.4 5.8 5 0 0 5 5 5 3 Repeating coiled region of VPS13 VPS13_C PF16909.5 EFE40612.1 - 6.9e-72 241.0 8.4 4.3e-70 235.1 0.3 3.2 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EFE40612.1 - 5.9e-34 116.7 0.0 1.8e-33 115.1 0.0 1.9 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EFE40612.1 - 0.0061 16.9 0.0 0.043 14.2 0.0 2.5 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF896 PF05979.12 EFE40612.1 - 2.3 8.1 4.7 1 9.3 0.8 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) DUF3429 PF11911.8 EFE40613.1 - 3.9e-44 150.4 13.6 6e-44 149.8 13.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) FGGY_C PF02782.16 EFE40614.1 - 8.4e-67 224.7 0.6 2.4e-66 223.3 0.4 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EFE40614.1 - 2.2e-64 217.3 0.0 3.1e-64 216.9 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EFE40614.1 - 0.058 12.9 0.7 0.38 10.2 0.0 2.1 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Peptidase_M41 PF01434.18 EFE40615.1 - 3.6e-54 183.5 0.1 6.7e-54 182.6 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EFE40615.1 - 2.8e-42 144.3 0.0 6e-42 143.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE40615.1 - 9e-10 38.2 0.2 2.3e-09 36.9 0.0 1.8 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 EFE40615.1 - 2.3e-05 24.4 0.0 6.4e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFE40615.1 - 5.8e-05 22.4 0.0 0.00012 21.4 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EFE40615.1 - 8.8e-05 22.8 0.2 0.012 15.9 0.2 3.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFE40615.1 - 9.5e-05 22.8 3.0 0.00042 20.7 0.6 2.9 3 1 0 3 3 2 1 AAA ATPase domain RuvB_N PF05496.12 EFE40615.1 - 0.00062 19.6 0.0 0.0018 18.0 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFE40615.1 - 0.0013 18.9 0.0 0.0047 17.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EFE40615.1 - 0.0047 17.1 0.0 0.017 15.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 EFE40615.1 - 0.0072 16.1 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EFE40615.1 - 0.012 16.1 0.0 0.047 14.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFE40615.1 - 0.014 15.0 1.7 0.67 9.5 0.2 2.4 1 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EFE40615.1 - 0.021 14.2 0.3 0.04 13.3 0.3 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EFE40615.1 - 0.025 13.7 0.0 0.048 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATPase PF06745.13 EFE40615.1 - 0.04 13.2 0.1 1.4 8.2 0.0 2.6 3 0 0 3 3 3 0 KaiC AAA_28 PF13521.6 EFE40615.1 - 0.045 14.0 0.4 0.14 12.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EFE40615.1 - 0.064 13.2 0.4 2 8.3 0.1 2.4 2 0 0 2 2 2 0 NACHT domain TsaE PF02367.17 EFE40615.1 - 0.072 13.1 0.0 0.3 11.1 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EFE40615.1 - 0.082 12.9 0.0 0.37 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EFE40615.1 - 0.12 12.8 0.2 0.4 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFE40615.1 - 0.17 11.2 1.0 0.63 9.3 0.4 2.1 1 1 1 2 2 2 0 Zeta toxin NTP_transferase PF00483.23 EFE40617.1 - 5.9e-34 117.8 0.0 1.2e-33 116.8 0.0 1.4 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 EFE40617.1 - 3.1e-15 55.2 9.8 1.4e-10 40.5 3.0 3.8 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFE40617.1 - 2.4e-06 27.2 1.3 2.4e-06 27.2 1.3 3.3 3 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.7 EFE40617.1 - 2.8e-05 24.5 0.0 4.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 EFE40617.1 - 0.0062 14.7 0.2 0.009 14.2 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) adh_short PF00106.25 EFE40618.1 - 3.8e-09 36.3 0.0 0.00019 21.0 0.0 3.3 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFE40618.1 - 0.00016 21.3 0.0 0.081 12.5 0.0 2.4 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Suc_Fer-like PF06999.12 EFE40621.1 - 7.2e-70 234.8 0.0 8.9e-70 234.5 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like NICE-3 PF07406.11 EFE40622.1 - 0.00089 19.3 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 NICE-3 protein DUF4129 PF13559.6 EFE40622.1 - 0.058 13.7 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) DUF3810 PF12725.7 EFE40622.1 - 0.63 9.3 2.3 0.86 8.9 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) GCFC PF07842.12 EFE40623.1 - 1.8e-86 290.2 10.4 3.1e-86 289.4 10.4 1.4 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EFE40623.1 - 5.2e-16 58.3 0.5 9.7e-16 57.4 0.5 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFE40623.1 - 4.2e-07 30.0 0.2 1.3e-06 28.3 0.2 1.9 1 0 0 1 1 1 1 G-patch domain DUF4455 PF14643.6 EFE40623.1 - 0.012 14.4 1.8 0.02 13.6 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) DUF5344 PF17279.2 EFE40623.1 - 0.081 13.5 0.8 0.18 12.4 0.8 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5344) ATP-synt_E PF05680.12 EFE40623.1 - 7.1 7.0 8.2 0.62 10.4 1.5 2.6 2 0 0 2 2 2 0 ATP synthase E chain Sod_Fe_N PF00081.22 EFE40624.1 - 6.7e-30 103.4 0.9 1.1e-29 102.8 0.9 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sod_Fe_C PF02777.18 EFE40624.1 - 1.9e-19 69.7 0.6 2.5e-11 43.6 0.0 2.4 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Cnn_1N PF07989.11 EFE40625.1 - 4e-06 26.9 15.5 1.5e-05 25.1 15.5 1.9 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 DUF724 PF05266.14 EFE40625.1 - 0.067 13.0 8.1 0.13 12.1 8.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Prominin PF05478.11 EFE40625.1 - 0.31 8.9 5.3 0.45 8.4 5.3 1.1 1 0 0 1 1 1 0 Prominin YabA PF06156.13 EFE40625.1 - 0.32 11.6 9.3 0.99 10.1 9.3 1.9 1 0 0 1 1 1 0 Initiation control protein YabA UPF0242 PF06785.11 EFE40625.1 - 0.6 10.2 17.6 1.1 9.4 17.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AAA_23 PF13476.6 EFE40625.1 - 0.69 10.4 12.3 1.3 9.4 12.3 1.5 1 0 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 EFE40625.1 - 3.4 7.1 9.3 6.5 6.2 9.3 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit BLOC1_2 PF10046.9 EFE40625.1 - 6.8 7.1 12.8 7.6 6.9 4.2 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1764 PF08576.10 EFE40626.1 - 0.54 11.2 7.4 0.69 10.8 7.4 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Connexin PF00029.19 EFE40626.1 - 1.3 8.8 2.5 1.4 8.7 2.5 1.1 1 0 0 1 1 1 0 Connexin Ribosomal_60s PF00428.19 EFE40627.1 - 0.041 14.5 28.9 0.11 13.2 9.3 3.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein DNA_pol_phi PF04931.13 EFE40627.1 - 0.13 10.3 5.5 0.23 9.5 5.5 1.3 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 EFE40627.1 - 0.43 11.0 12.8 0.11 12.9 8.6 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TFIIA PF03153.13 EFE40628.1 - 0.42 10.6 49.7 0.028 14.4 18.3 3.3 2 1 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit PH_10 PF15411.6 EFE40630.1 - 4e-31 107.8 0.1 9.5e-31 106.6 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.24 EFE40630.1 - 3.1e-08 33.4 0.0 6.7e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 PB1 domain CDC24 PF06395.11 EFE40631.1 - 6e-31 106.5 0.0 2.9e-30 104.3 0.0 2.0 2 0 0 2 2 2 1 CDC24 Calponin RhoGEF PF00621.20 EFE40631.1 - 5.2e-26 92.0 0.6 9.7e-26 91.1 0.6 1.5 1 0 0 1 1 1 1 RhoGEF domain WD40 PF00400.32 EFE40632.1 - 1e-26 92.6 14.7 0.00012 22.8 0.1 7.7 8 0 0 8 8 8 5 WD domain, G-beta repeat F-box-like PF12937.7 EFE40632.1 - 1.5e-11 44.0 0.3 3e-11 43.0 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE40632.1 - 2.2e-07 30.6 0.1 5.9e-07 29.2 0.1 1.7 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EFE40632.1 - 0.00049 20.3 0.2 24 5.3 0.0 4.1 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFE40632.1 - 0.00096 19.2 0.0 3.9 7.6 0.0 3.8 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region FliO PF04347.13 EFE40632.1 - 0.13 12.6 0.0 1.1 9.6 0.0 2.5 3 0 0 3 3 3 0 Flagellar biosynthesis protein, FliO Nup160 PF11715.8 EFE40632.1 - 0.16 10.5 0.4 8.6 4.9 0.1 2.4 2 0 0 2 2 2 0 Nucleoporin Nup120/160 WD40_like PF17005.5 EFE40632.1 - 0.2 11.0 0.0 11 5.2 0.0 2.8 3 0 0 3 3 3 0 WD40-like domain SOCS PF12610.8 EFE40633.1 - 1.8 9.0 7.5 3 8.3 0.0 3.3 3 0 0 3 3 3 0 Suppressor of cytokine signalling Uds1 PF15456.6 EFE40634.1 - 1.1e-38 132.3 2.4 1.1e-38 132.3 2.4 6.4 4 2 2 6 6 6 1 Up-regulated During Septation TPR_MLP1_2 PF07926.12 EFE40634.1 - 0.00049 20.2 20.9 0.006 16.7 17.8 8.2 6 1 4 10 10 10 3 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.8 EFE40634.1 - 0.00062 19.7 9.5 0.00062 19.7 9.5 9.5 10 1 1 11 11 11 3 TATA element modulatory factor 1 DNA binding DUF4472 PF14739.6 EFE40634.1 - 0.015 16.0 10.6 0.015 16.0 10.6 6.6 3 2 2 6 6 6 0 Domain of unknown function (DUF4472) ApoO PF09769.9 EFE40634.1 - 0.3 11.0 12.5 1.4 8.9 1.9 4.3 3 1 2 5 5 5 0 Apolipoprotein O Taxilin PF09728.9 EFE40634.1 - 9.5 5.3 54.5 0.093 11.9 22.8 5.0 3 1 1 4 4 4 0 Myosin-like coiled-coil protein Baculo_PEP_C PF04513.12 EFE40634.1 - 10 6.2 29.8 6 6.9 1.6 6.0 2 2 3 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus MFS_1 PF07690.16 EFE40635.1 - 3.7e-19 68.9 31.3 6.2e-19 68.1 31.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UCR_hinge PF02320.16 EFE40636.1 - 2.1e-23 82.3 7.4 2.1e-23 82.3 7.4 2.1 1 1 1 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein Sigma70_ner PF04546.13 EFE40636.1 - 0.0065 16.4 5.3 0.0077 16.1 5.3 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region ORC_WH_C PF18137.1 EFE40636.1 - 0.051 13.6 1.2 0.083 13.0 1.2 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Radial_spoke PF04712.12 EFE40636.1 - 0.19 10.7 8.0 0.2 10.5 8.0 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein Ribosomal_60s PF00428.19 EFE40636.1 - 0.21 12.2 13.7 0.47 11.1 13.7 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein DNA_pol_phi PF04931.13 EFE40636.1 - 1.4 6.9 11.4 1.5 6.8 11.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Vps36_ESCRT-II PF11605.8 EFE40637.1 - 0.00037 20.6 0.0 0.11 12.7 0.0 2.3 1 1 1 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 DUF3439 PF11921.8 EFE40637.1 - 0.02 14.9 5.2 0.025 14.5 4.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Mucin PF01456.17 EFE40637.1 - 1 9.3 12.8 1.7 8.7 12.8 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 EFE40637.1 - 1.3 6.9 3.6 1.6 6.6 3.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 EFE40637.1 - 4.6 5.3 10.6 6.5 4.8 10.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Hid1 PF12722.7 EFE40638.1 - 2.9 5.9 18.6 3.5 5.6 18.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Kei1 PF08552.11 EFE40638.1 - 5.8 6.7 7.5 12 5.7 7.5 1.7 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SAPS PF04499.15 EFE40638.1 - 8.9 5.0 17.0 11 4.7 17.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nha1_C PF08619.10 EFE40639.1 - 0.29 10.3 0.0 0.29 10.3 0.0 3.0 3 0 0 3 3 3 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF3413 PF11893.8 EFE40639.1 - 0.45 9.6 3.1 0.68 9.1 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) Acyltransferase PF01553.21 EFE40640.1 - 6.9e-10 38.7 0.0 0.00035 20.2 0.0 2.4 2 0 0 2 2 2 2 Acyltransferase Prenyltransf PF01255.19 EFE40641.1 - 2.2e-81 272.7 0.1 6.3e-81 271.2 0.1 1.7 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Tmemb_cc2 PF10267.9 EFE40641.1 - 0.00097 18.4 2.4 0.0014 17.9 2.4 1.2 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein SelP_N PF04592.14 EFE40641.1 - 0.86 9.0 15.4 1.4 8.2 15.4 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Macoilin PF09726.9 EFE40641.1 - 2.4 6.6 9.0 4 5.9 9.0 1.3 1 0 0 1 1 1 0 Macoilin family CCDC106 PF15794.5 EFE40641.1 - 2.6 7.7 7.3 4.5 6.9 7.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Sacchrp_dh_C PF16653.5 EFE40643.1 - 1.1e-92 310.9 0.0 2e-92 310.0 0.0 1.4 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain UPF0231 PF06062.11 EFE40644.1 - 0.11 12.8 5.1 0.11 12.7 5.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) Ribosomal_60s PF00428.19 EFE40647.1 - 0.00026 21.5 5.7 0.00032 21.2 5.7 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Myc_N PF01056.18 EFE40647.1 - 0.089 12.7 5.1 0.093 12.6 5.1 1.0 1 0 0 1 1 1 0 Myc amino-terminal region DUF4366 PF14283.6 EFE40647.1 - 0.091 12.8 3.6 0.1 12.6 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF4746 PF15928.5 EFE40647.1 - 0.51 9.7 8.2 0.56 9.6 8.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MAS20 PF02064.15 EFE40647.1 - 0.9 9.6 4.5 1.2 9.2 4.5 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor NPR3 PF03666.13 EFE40647.1 - 3.7 6.2 8.7 4 6.1 8.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF778 PF05608.12 EFE40647.1 - 4.1 7.7 5.0 4.6 7.6 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF778) FancD2 PF14631.6 EFE40647.1 - 4.3 4.6 5.8 4.4 4.6 5.8 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease XRCC4 PF06632.12 EFE40647.1 - 7.2 5.4 11.5 9.1 5.0 11.5 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 SR-25 PF10500.9 EFE40649.1 - 0.00099 18.8 1.3 0.0012 18.5 1.3 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TRAP_alpha PF03896.16 EFE40649.1 - 0.0037 16.5 5.3 0.0054 16.0 5.3 1.3 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 EFE40649.1 - 0.0041 16.5 11.4 0.0054 16.1 11.4 1.2 1 0 0 1 1 1 1 NOA36 protein Zip PF02535.22 EFE40649.1 - 0.0066 15.7 0.0 0.0076 15.5 0.0 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter DUF2722 PF10846.8 EFE40649.1 - 0.023 13.6 3.8 0.026 13.5 3.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) GCIP PF13324.6 EFE40649.1 - 0.034 13.7 3.5 0.045 13.4 3.5 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting SDA1 PF05285.12 EFE40649.1 - 0.035 13.5 13.2 0.04 13.3 13.2 1.1 1 0 0 1 1 1 0 SDA1 DREPP PF05558.12 EFE40649.1 - 0.037 13.9 7.7 0.047 13.6 7.7 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Cwf_Cwc_15 PF04889.12 EFE40649.1 - 0.047 13.4 10.9 0.068 12.9 10.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RPN2_C PF18004.1 EFE40649.1 - 0.055 13.4 4.1 0.066 13.1 4.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Radial_spoke PF04712.12 EFE40649.1 - 0.06 12.3 5.6 0.071 12.0 5.6 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Roughex PF06020.11 EFE40649.1 - 0.07 12.2 6.7 0.092 11.8 6.7 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Cytochrom_B558a PF05038.13 EFE40649.1 - 0.095 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit RNA_pol_3_Rpc31 PF11705.8 EFE40649.1 - 0.11 12.7 13.2 0.17 12.2 13.2 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PPP4R2 PF09184.11 EFE40649.1 - 0.13 11.8 15.9 0.16 11.5 15.9 1.1 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 EFE40649.1 - 0.16 10.1 13.7 0.18 10.0 13.7 1.0 1 0 0 1 1 1 0 Nop14-like family DUF913 PF06025.12 EFE40649.1 - 0.19 10.7 1.5 0.22 10.5 1.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFB6 PF17110.5 EFE40649.1 - 0.21 11.3 4.4 0.26 11.0 4.4 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF4746 PF15928.5 EFE40649.1 - 0.36 10.2 8.0 0.41 10.0 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DNA_pol_phi PF04931.13 EFE40649.1 - 0.6 8.1 21.0 0.77 7.8 21.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi CAF1A PF12253.8 EFE40649.1 - 0.62 10.3 15.5 0.93 9.7 15.5 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A CobT PF06213.12 EFE40649.1 - 0.67 9.3 13.0 0.84 9.0 13.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT XAP5 PF04921.14 EFE40649.1 - 1.1 9.0 7.8 1.5 8.6 7.8 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator BUD22 PF09073.10 EFE40649.1 - 1.1 8.5 12.4 1.3 8.3 12.4 1.1 1 0 0 1 1 1 0 BUD22 DUF5520 PF17658.1 EFE40649.1 - 1.4 7.9 4.7 1.8 7.6 4.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5520) RRN3 PF05327.11 EFE40649.1 - 2.1 6.8 8.5 2.5 6.6 8.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 EFE40649.1 - 2.6 6.2 11.8 3.2 5.9 11.8 1.1 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 EFE40649.1 - 5 7.2 16.4 7.8 6.5 16.4 1.3 1 0 0 1 1 1 0 YL1 nuclear protein SGT1 PF07093.11 EFE40649.1 - 8.1 4.8 11.1 10 4.4 11.1 1.0 1 0 0 1 1 1 0 SGT1 protein AAA_2 PF07724.14 EFE40651.1 - 3.7e-44 150.8 0.0 2.3e-42 145.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EFE40651.1 - 1e-32 112.2 6.9 2e-32 111.2 1.4 3.7 3 0 0 3 3 3 1 AAA lid domain AAA PF00004.29 EFE40651.1 - 5.2e-26 91.6 0.0 1.2e-14 54.8 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EFE40651.1 - 1.4e-22 79.5 0.1 5.5e-22 77.6 0.1 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EFE40651.1 - 1.3e-14 54.4 1.2 1e-07 32.1 0.0 3.9 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFE40651.1 - 8.8e-14 52.2 0.7 3.2e-07 30.9 0.0 4.3 3 2 0 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 EFE40651.1 - 2.1e-12 47.5 0.7 0.00021 21.6 0.0 4.1 2 2 1 3 3 3 2 AAA domain Sigma54_activat PF00158.26 EFE40651.1 - 5.6e-09 35.9 0.0 6.8e-05 22.6 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Clp_N PF02861.20 EFE40651.1 - 1.9e-07 31.1 5.3 0.0015 18.6 0.1 4.2 3 1 0 3 3 2 2 Clp amino terminal domain, pathogenicity island component AAA_7 PF12775.7 EFE40651.1 - 7.8e-07 28.8 0.0 0.013 15.1 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region TniB PF05621.11 EFE40651.1 - 9.2e-07 28.4 1.9 0.21 11.0 0.0 5.1 5 1 1 6 6 5 2 Bacterial TniB protein IstB_IS21 PF01695.17 EFE40651.1 - 2.7e-06 27.2 0.0 0.096 12.4 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 EFE40651.1 - 8e-06 25.9 0.0 0.11 12.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EFE40651.1 - 1.1e-05 26.0 0.0 0.12 13.0 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EFE40651.1 - 1.1e-05 25.6 0.0 0.26 11.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EFE40651.1 - 4e-05 23.1 0.0 0.16 11.3 0.0 3.4 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EFE40651.1 - 4.1e-05 23.9 0.0 0.57 10.6 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 EFE40651.1 - 4.4e-05 23.8 0.8 1.3 9.3 0.0 3.6 3 0 0 3 3 3 2 AAA domain RuvB_N PF05496.12 EFE40651.1 - 7.8e-05 22.5 1.6 2 8.1 1.3 4.4 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EFE40651.1 - 0.00013 22.0 0.0 0.15 12.1 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 EFE40651.1 - 0.00015 21.7 0.0 1.4 8.8 0.0 3.4 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EFE40651.1 - 0.00018 21.5 7.0 0.32 10.9 0.1 4.6 5 1 0 5 5 4 2 ATPase domain predominantly from Archaea AAA_23 PF13476.6 EFE40651.1 - 0.00029 21.4 8.5 0.22 12.0 0.0 4.7 5 0 0 5 5 5 1 AAA domain AAA_30 PF13604.6 EFE40651.1 - 0.00034 20.4 0.0 0.55 9.9 0.0 3.4 3 0 0 3 3 2 1 AAA domain ABC_tran PF00005.27 EFE40651.1 - 0.00039 21.0 0.2 0.95 10.0 0.0 3.2 3 0 0 3 3 2 1 ABC transporter RsgA_GTPase PF03193.16 EFE40651.1 - 0.00057 19.8 0.1 0.81 9.6 0.0 3.0 3 0 0 3 3 2 1 RsgA GTPase AAA_24 PF13479.6 EFE40651.1 - 0.00081 19.2 0.0 0.71 9.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain Torsin PF06309.11 EFE40651.1 - 0.0016 18.6 0.0 0.0059 16.7 0.0 1.8 2 0 0 2 2 1 1 Torsin NTPase_1 PF03266.15 EFE40651.1 - 0.0026 17.7 0.1 0.1 12.5 0.0 3.2 3 0 0 3 3 3 1 NTPase AAA_19 PF13245.6 EFE40651.1 - 0.003 17.9 0.1 0.82 10.0 0.1 3.1 2 1 0 3 3 3 1 AAA domain T2SSE PF00437.20 EFE40651.1 - 0.0061 15.6 0.0 0.06 12.4 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein Zeta_toxin PF06414.12 EFE40651.1 - 0.0062 15.8 0.0 2.7 7.2 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 EFE40651.1 - 0.0063 16.5 0.0 0.37 10.7 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_29 PF13555.6 EFE40651.1 - 0.0067 16.1 0.0 6.9 6.5 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.15 EFE40651.1 - 0.0071 16.3 0.0 7.2 6.5 0.0 2.9 3 0 0 3 3 2 0 Rad17 P-loop domain SRP54 PF00448.22 EFE40651.1 - 0.01 15.5 0.1 1.6 8.4 0.0 2.8 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain Roc PF08477.13 EFE40651.1 - 0.01 16.1 0.0 2.7 8.2 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 EFE40651.1 - 0.018 14.6 0.2 2.3 7.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EFE40651.1 - 0.022 14.8 0.0 3 7.8 0.0 3.2 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit MMR_HSR1 PF01926.23 EFE40651.1 - 0.059 13.5 0.8 2.7 8.1 0.1 3.6 3 1 0 3 3 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 EFE40651.1 - 0.11 11.7 0.0 1.4 8.1 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain ATP_bind_1 PF03029.17 EFE40651.1 - 0.15 11.8 0.0 19 5.0 0.0 2.9 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein FRQ PF09421.10 EFE40651.1 - 0.27 9.2 3.5 0.52 8.3 3.5 1.3 1 0 0 1 1 1 0 Frequency clock protein SNF2_N PF00176.23 EFE40652.1 - 2e-62 211.0 0.0 3e-62 210.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE40652.1 - 3.5e-15 56.3 0.0 7.5e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE40652.1 - 2.6e-09 37.3 0.0 1.1e-08 35.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EFE40652.1 - 0.0072 15.5 0.0 0.016 14.4 0.0 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 EBP PF05241.12 EFE40653.1 - 8.8e-51 171.9 9.7 1.8e-50 170.9 9.7 1.4 1 1 0 1 1 1 1 Emopamil binding protein DUF4484 PF14831.6 EFE40654.1 - 1.4e-62 211.5 1.1 2.3e-62 210.8 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) DUF2347 PF09804.9 EFE40654.1 - 3.4e-49 167.9 0.0 7.5e-49 166.8 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Avl9 PF09794.9 EFE40654.1 - 0.032 12.9 0.0 0.039 12.7 0.0 1.1 1 0 0 1 1 1 0 Transport protein Avl9 Barttin PF15462.6 EFE40654.1 - 0.081 12.7 1.4 0.24 11.2 1.4 1.7 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Homez PF11569.8 EFE40654.1 - 0.1 12.1 0.1 0.3 10.6 0.1 1.8 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez SPA PF08616.10 EFE40654.1 - 0.16 12.0 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Stabilization of polarity axis DinB_2 PF12867.7 EFE40655.1 - 0.084 13.4 1.1 3 8.4 0.0 2.7 2 0 0 2 2 2 0 DinB superfamily TTKRSYEDQ PF10212.9 EFE40655.1 - 0.27 10.2 8.6 0.95 8.4 4.0 2.1 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Spc7 PF08317.11 EFE40655.1 - 0.96 8.3 19.1 1.7 7.4 19.1 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 EFE40655.1 - 1.1 8.7 10.1 2.2 7.8 10.1 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit FapA PF03961.13 EFE40655.1 - 2.7 6.5 7.6 4.3 5.8 7.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Luteo_P1-P2 PF08467.10 EFE40655.1 - 4.2 6.5 9.3 38 3.4 9.2 2.3 2 1 0 2 2 2 0 Luteovirus RNA polymerase P1-P2/replicase Tubulin_3 PF14881.6 EFE40656.1 - 1.2e-82 275.9 0.1 2.3e-82 275.1 0.1 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 EFE40656.1 - 3.6e-41 140.2 0.0 8e-41 139.0 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 EFE40656.1 - 6.7e-07 29.7 0.0 0.0019 18.4 0.0 2.3 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain PP2C PF00481.21 EFE40657.1 - 2.1e-60 204.5 0.1 2.3e-52 178.2 0.0 3.0 2 1 0 2 2 2 2 Protein phosphatase 2C CUE PF02845.16 EFE40659.1 - 5.1e-11 42.1 0.0 8.8e-11 41.3 0.0 1.4 1 0 0 1 1 1 1 CUE domain eRF1_2 PF03464.15 EFE40659.1 - 0.026 14.8 0.0 0.048 14.0 0.0 1.4 1 0 0 1 1 1 0 eRF1 domain 2 HA2 PF04408.23 EFE40660.1 - 5.1e-17 62.1 0.0 1.1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFE40660.1 - 2.2e-14 53.6 0.0 4.5e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFE40660.1 - 6e-12 45.9 0.0 2e-11 44.2 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE40660.1 - 1.4e-05 24.9 0.0 3.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFE40660.1 - 0.00023 21.5 0.1 0.00094 19.5 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFE40660.1 - 0.00031 20.5 0.0 0.00068 19.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFE40660.1 - 0.0038 17.6 0.0 0.0092 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EFE40660.1 - 0.018 14.7 0.1 0.23 11.0 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 EFE40660.1 - 0.035 13.2 0.1 0.1 11.7 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein ABC_tran PF00005.27 EFE40660.1 - 0.058 13.9 0.0 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter PITH PF06201.13 EFE40661.1 - 1.2e-26 93.8 0.0 1.8e-12 47.7 0.0 2.1 1 1 1 2 2 2 2 PITH domain Snf7 PF03357.21 EFE40662.1 - 1.2e-29 103.2 9.7 1.4e-29 102.9 9.7 1.1 1 0 0 1 1 1 1 Snf7 DHDPS PF00701.22 EFE40662.1 - 0.0047 15.7 0.5 0.0087 14.8 0.3 1.4 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family MtaB PF12176.8 EFE40662.1 - 0.58 8.9 2.5 5.9 5.6 0.1 2.1 2 0 0 2 2 2 0 Methanol-cobalamin methyltransferase B subunit HSCB_C PF07743.13 EFE40662.1 - 1.1 9.7 10.5 1.7 9.2 3.3 2.6 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain Adhes-Ig_like PF09085.10 EFE40662.1 - 2.7 8.1 5.4 3.9 7.6 3.2 2.4 1 1 1 2 2 2 0 Adhesion molecule, immunoglobulin-like AAA PF00004.29 EFE40663.1 - 4.1e-91 302.3 0.0 1.3e-45 155.1 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE40663.1 - 2.6e-18 65.5 2.0 9.9e-09 34.9 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EFE40663.1 - 2.2e-14 54.2 0.9 0.0002 21.8 0.0 4.8 2 2 1 4 4 4 2 AAA ATPase domain RuvB_N PF05496.12 EFE40663.1 - 3e-13 49.8 0.0 5.5e-06 26.2 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFE40663.1 - 1.4e-11 44.8 0.2 0.0076 16.5 0.0 5.1 2 2 2 4 4 4 2 AAA domain AAA_2 PF07724.14 EFE40663.1 - 9.3e-11 42.1 0.0 0.00032 20.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EFE40663.1 - 1e-10 42.0 0.0 3.4e-05 24.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EFE40663.1 - 4.8e-10 39.6 0.5 0.00086 19.3 0.0 4.2 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFE40663.1 - 3.5e-09 36.3 0.2 0.00015 21.1 0.0 2.6 3 0 0 3 3 3 2 TIP49 P-loop domain RNA_helicase PF00910.22 EFE40663.1 - 6.5e-08 32.9 0.0 0.0064 16.9 0.0 2.7 2 1 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EFE40663.1 - 1.6e-07 31.4 0.0 0.015 15.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EFE40663.1 - 3.5e-07 30.8 0.0 0.013 16.1 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.6 EFE40663.1 - 5.1e-07 30.1 0.0 0.0075 16.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EFE40663.1 - 7.7e-07 28.7 1.9 0.022 14.1 0.1 2.8 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EFE40663.1 - 8.3e-07 28.9 0.1 0.06 13.1 0.0 2.6 2 1 0 2 2 2 2 IstB-like ATP binding protein Zeta_toxin PF06414.12 EFE40663.1 - 9.8e-07 28.2 0.0 0.033 13.5 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_3 PF07726.11 EFE40663.1 - 1.2e-06 28.4 0.0 0.004 17.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFE40663.1 - 9.1e-06 25.7 0.0 0.14 12.0 0.0 3.4 3 0 0 3 3 3 2 NACHT domain TsaE PF02367.17 EFE40663.1 - 1.1e-05 25.5 0.0 0.079 13.0 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 EFE40663.1 - 1.5e-05 25.0 0.0 0.087 12.7 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_7 PF12775.7 EFE40663.1 - 3.9e-05 23.2 0.0 0.13 11.8 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region ABC_tran PF00005.27 EFE40663.1 - 5e-05 23.8 0.0 0.18 12.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter Cytidylate_kin2 PF13189.6 EFE40663.1 - 5.1e-05 23.5 0.0 0.017 15.3 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_25 PF13481.6 EFE40663.1 - 7.2e-05 22.5 0.6 1.3 8.6 0.0 3.9 3 1 1 4 4 4 2 AAA domain AAA_17 PF13207.6 EFE40663.1 - 7.5e-05 23.2 0.0 0.19 12.2 0.0 3.2 2 1 0 2 2 2 1 AAA domain ATPase PF06745.13 EFE40663.1 - 8.6e-05 22.0 0.1 0.69 9.2 0.0 3.1 2 1 1 3 3 3 2 KaiC Sigma54_activat PF00158.26 EFE40663.1 - 0.0001 22.0 0.0 0.38 10.4 0.0 3.0 2 1 0 2 2 2 2 Sigma-54 interaction domain PhoH PF02562.16 EFE40663.1 - 0.0004 19.9 0.0 0.54 9.7 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_11 PF13086.6 EFE40663.1 - 0.00041 20.2 0.2 1.2 8.9 0.0 2.7 3 0 0 3 3 3 2 AAA domain TniB PF05621.11 EFE40663.1 - 0.00041 19.8 0.0 0.13 11.6 0.0 3.1 3 0 0 3 3 3 1 Bacterial TniB protein AFG1_ATPase PF03969.16 EFE40663.1 - 0.00046 19.2 0.0 0.089 11.7 0.0 2.5 2 0 0 2 2 2 1 AFG1-like ATPase NB-ARC PF00931.22 EFE40663.1 - 0.00053 19.2 0.0 1 8.5 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain SKI PF01202.22 EFE40663.1 - 0.00073 19.7 0.0 0.8 9.8 0.0 2.8 2 0 0 2 2 2 1 Shikimate kinase ATPase_2 PF01637.18 EFE40663.1 - 0.00078 19.4 0.0 1.8 8.4 0.0 3.5 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 EFE40663.1 - 0.00086 19.1 0.0 0.6 9.8 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 EFE40663.1 - 0.001 18.8 0.0 0.89 9.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 EFE40663.1 - 0.0011 19.1 0.0 2.4 8.3 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain DUF815 PF05673.13 EFE40663.1 - 0.0012 18.1 0.0 0.049 12.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 EFE40663.1 - 0.002 17.3 0.0 1.7 7.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 EFE40663.1 - 0.014 15.8 1.9 4 7.7 0.2 3.1 2 1 0 2 2 2 0 AAA domain CPT PF07931.12 EFE40663.1 - 0.019 14.8 0.0 0.48 10.3 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein ResIII PF04851.15 EFE40663.1 - 0.023 14.7 0.0 8.7 6.3 0.0 2.9 2 1 1 3 3 2 0 Type III restriction enzyme, res subunit Vps4_C PF09336.10 EFE40663.1 - 0.029 14.3 0.4 1.8 8.6 0.1 3.1 2 1 0 2 2 2 0 Vps4 C terminal oligomerisation domain AAA_23 PF13476.6 EFE40663.1 - 0.039 14.5 1.4 5.6 7.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain IPT PF01745.16 EFE40663.1 - 0.059 12.7 0.1 7.7 5.8 0.0 2.6 3 0 0 3 3 2 0 Isopentenyl transferase DUF2075 PF09848.9 EFE40663.1 - 0.08 12.2 0.0 4.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EFE40663.1 - 0.11 12.4 0.0 11 5.9 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_30 PF13604.6 EFE40663.1 - 0.13 11.9 0.3 17 5.0 0.0 2.6 3 0 0 3 3 2 0 AAA domain Cytidylate_kin PF02224.18 EFE40663.1 - 0.16 11.7 0.1 13 5.4 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase BOP1NT PF08145.12 EFE40664.1 - 4.9e-105 351.1 6.6 8.2e-105 350.4 6.6 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EFE40664.1 - 8.6e-21 73.9 8.4 1.1e-09 38.7 0.2 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE40664.1 - 5.6e-05 23.4 0.0 0.032 14.5 0.0 3.7 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EFE40664.1 - 0.061 13.8 2.4 16 6.1 0.0 4.2 4 0 0 4 4 4 0 PQQ-like domain Leo1 PF04004.13 EFE40666.1 - 4.8e-29 101.3 0.8 4.8e-29 101.3 0.8 2.4 2 1 0 2 2 2 1 Leo1-like protein EF-1_beta_acid PF10587.9 EFE40666.1 - 0.048 14.1 4.2 0.048 14.1 4.2 6.9 6 1 0 6 6 6 0 Eukaryotic elongation factor 1 beta central acidic region FAM176 PF14851.6 EFE40667.1 - 1.3 8.6 8.7 1.2 8.7 8.7 1.0 1 0 0 1 1 1 0 FAM176 family Nucleo_P87 PF07267.11 EFE40667.1 - 9.1 5.0 9.8 8.5 5.1 9.8 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Mob1_phocein PF03637.17 EFE40668.1 - 3.9e-52 176.7 0.0 1e-51 175.3 0.0 1.7 1 1 0 1 1 1 1 Mob1/phocein family IF-2B PF01008.17 EFE40669.1 - 1.5e-56 191.7 7.0 2.7e-46 158.0 2.8 3.0 2 1 0 2 2 2 2 Initiation factor 2 subunit family Ribosom_S12_S23 PF00164.25 EFE40670.1 - 3.2e-50 168.5 1.0 4e-50 168.2 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF5315 PF17242.2 EFE40671.1 - 4.3e-19 68.1 0.0 1.3e-18 66.6 0.0 1.8 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) THUMP PF02926.17 EFE40671.1 - 0.034 14.2 0.7 0.052 13.7 0.7 1.2 1 0 0 1 1 1 0 THUMP domain NBP1 PF08537.10 EFE40671.1 - 0.11 11.9 3.3 1.1 8.5 1.9 2.0 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 AIM5 PF17050.5 EFE40672.1 - 2.7e-11 44.1 0.2 4.9e-11 43.3 0.2 1.5 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 PulG PF11773.8 EFE40672.1 - 0.11 12.4 0.1 0.16 11.8 0.1 1.2 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin Ribosomal_L17 PF01196.19 EFE40673.1 - 3.7e-34 117.5 0.0 8.2e-34 116.4 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L17 Mrpl_C PF18502.1 EFE40673.1 - 0.041 14.2 0.1 0.47 10.7 0.0 2.0 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain Metallophos_2 PF12850.7 EFE40674.1 - 2.9e-13 50.4 0.0 3.4e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF202 PF02656.15 EFE40676.1 - 3.4e-14 53.0 4.5 3.4e-14 53.0 4.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF5337 PF17272.2 EFE40676.1 - 1.1 9.2 9.8 0.19 11.6 5.1 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5337) Tctex-1 PF03645.13 EFE40677.1 - 1.9e-21 76.2 0.0 2.5e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family Self-incomp_S1 PF05938.11 EFE40677.1 - 0.083 13.4 0.0 0.098 13.2 0.0 1.2 1 0 0 1 1 1 0 Plant self-incompatibility protein S1 WD40 PF00400.32 EFE40678.1 - 1.1e-32 111.5 18.8 1.3e-09 38.5 0.2 8.4 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE40678.1 - 1.2e-07 31.9 0.5 0.02 15.2 0.0 4.4 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE40678.1 - 8.4e-06 24.7 1.6 0.055 12.1 0.2 3.8 5 0 0 5 5 5 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EFE40678.1 - 0.00088 18.3 0.4 0.0061 15.5 0.0 2.3 2 1 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 EFE40678.1 - 0.0032 16.5 0.0 1.7 7.5 0.0 3.4 3 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 EFE40678.1 - 0.053 13.2 0.5 0.29 10.8 0.2 2.4 2 1 0 2 2 2 0 TUP1-like enhancer of split DUF2057 PF09829.9 EFE40679.1 - 0.069 13.3 0.5 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Filament PF00038.21 EFE40679.1 - 0.12 12.0 0.4 0.18 11.3 0.4 1.2 1 0 0 1 1 1 0 Intermediate filament protein ketoacyl-synt PF00109.26 EFE40680.1 - 4.6e-79 265.6 0.0 7.9e-79 264.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EFE40680.1 - 4.6e-40 137.9 1.2 1.8e-39 135.9 0.3 2.4 2 1 1 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 EFE40680.1 - 1.1e-34 119.0 0.2 3.1e-34 117.5 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EFE40680.1 - 1.7e-27 97.0 0.0 3.3e-27 96.1 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Acyl_transf_1 PF00698.21 EFE40680.1 - 2.3e-25 89.8 0.3 1.7e-18 67.2 0.0 2.3 1 1 1 2 2 2 2 Acyl transferase domain PS-DH PF14765.6 EFE40680.1 - 3.2e-14 52.8 0.0 5.9e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 EFE40680.1 - 3.8e-13 49.6 7.8 2.7e-06 27.6 0.4 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EFE40680.1 - 4.9e-08 33.4 0.0 1.6e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_6 PF12697.7 EFE40680.1 - 0.0044 17.7 0.1 0.015 16.0 0.1 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thiolase_N PF00108.23 EFE40680.1 - 0.009 15.4 0.0 0.023 14.1 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Abhydrolase_3 PF07859.13 EFE40680.1 - 0.0093 15.8 0.0 0.047 13.5 0.0 2.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Herpes_LAMP2 PF06126.11 EFE40680.1 - 0.72 8.4 2.2 1.2 7.7 2.2 1.2 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 FMO-like PF00743.19 EFE40681.1 - 4e-40 137.7 0.0 4.9e-40 137.4 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFE40681.1 - 9.5e-12 44.8 0.1 9.4e-09 34.9 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFE40681.1 - 9.4e-09 34.9 0.1 8.1e-05 22.0 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE40681.1 - 2.4e-06 26.9 1.2 5.4e-06 25.8 0.2 1.8 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Cas_Csa5 PF09702.10 EFE40681.1 - 0.019 15.2 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) Pyr_redox PF00070.27 EFE40681.1 - 0.1 13.2 0.2 0.21 12.2 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.25 EFE40682.1 - 1.5e-35 122.5 0.6 7.7e-35 120.1 0.1 2.4 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE40682.1 - 1.1e-32 113.5 0.3 2.1e-30 106.0 0.3 2.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE40682.1 - 1.5e-08 34.7 0.1 3.1e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EFE40682.1 - 0.011 16.0 0.1 0.019 15.2 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EFE40682.1 - 0.011 15.2 0.0 0.022 14.2 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Pyr_redox PF00070.27 EFE40682.1 - 0.055 14.0 0.8 0.11 13.0 0.8 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fasciclin PF02469.22 EFE40683.1 - 3.9e-36 124.1 0.0 9e-23 80.9 0.3 2.2 2 0 0 2 2 2 2 Fasciclin domain HHV-1_VABD PF16852.5 EFE40683.1 - 0.024 14.7 0.0 0.048 13.7 0.0 1.5 1 0 0 1 1 1 0 Herpes viral adaptor-to-host cellular mRNA binding domain Cu-oxidase_2 PF07731.14 EFE40684.1 - 5.2e-22 78.1 2.7 1.9e-21 76.3 0.5 2.3 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 EFE40684.1 - 1.8e-18 67.1 0.0 4.7e-18 65.8 0.0 1.7 1 1 0 1 1 1 1 Multicopper oxidase Sex_peptide PF08138.11 EFE40684.1 - 0.16 12.1 0.9 0.76 10.0 0.0 2.6 4 0 0 4 4 4 0 Sex peptide (SP) family Methyltransf_2 PF00891.18 EFE40685.1 - 1.1e-25 90.2 0.0 1.9e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EFE40685.1 - 0.031 15.0 0.0 0.4 11.4 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFE40685.1 - 0.1 13.3 0.0 0.41 11.4 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Uds1 PF15456.6 EFE40687.1 - 8.1e-29 100.4 3.7 1.3e-28 99.7 3.7 1.3 1 0 0 1 1 1 1 Up-regulated During Septation Stathmin PF00836.19 EFE40687.1 - 0.0045 16.9 0.9 0.019 15.0 0.2 2.3 2 0 0 2 2 2 1 Stathmin family Seryl_tRNA_N PF02403.22 EFE40687.1 - 0.13 12.5 1.5 20 5.4 0.0 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain GrpE PF01025.19 EFE40688.1 - 3.2e-42 144.0 3.0 4.5e-42 143.5 3.0 1.2 1 0 0 1 1 1 1 GrpE PEARLI-4 PF05278.12 EFE40688.1 - 0.032 13.8 2.5 0.048 13.3 2.5 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) DLEU7 PF15760.5 EFE40688.1 - 0.079 12.4 0.7 0.13 11.8 0.6 1.4 1 1 0 1 1 1 0 Leukemia-associated protein 7 HIP1_clath_bdg PF16515.5 EFE40688.1 - 0.44 11.2 5.5 2.9 8.5 3.0 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HSCB_C PF07743.13 EFE40688.1 - 1.3 9.6 8.0 0.75 10.3 2.5 2.3 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain tRNA-synt_2d PF01409.20 EFE40689.1 - 3.9e-47 160.8 0.1 8.8e-27 94.2 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EFE40689.1 - 1.3e-23 83.3 0.0 3.1e-23 82.0 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain RRM_1 PF00076.22 EFE40690.1 - 7.5e-16 57.7 0.0 1e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFE40690.1 - 0.12 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 EFE40690.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif SRA1 PF07304.11 EFE40691.1 - 5e-13 49.1 0.0 3.7e-12 46.2 0.0 2.6 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 EFE40691.1 - 1.2e-07 31.7 0.3 2.4e-06 27.4 0.3 2.2 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 EFE40691.1 - 3.7e-06 27.5 2.9 0.22 12.5 0.0 5.8 7 0 0 7 7 7 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE40691.1 - 0.00049 20.4 0.1 0.074 13.4 0.1 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Prp18 PF02840.15 EFE40691.1 - 0.0025 17.9 0.2 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 Prp18 domain Transp_cyt_pur PF02133.15 EFE40692.1 - 1.5e-21 76.7 34.1 2.2e-10 39.9 31.7 2.8 2 1 0 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin DUF1418 PF07214.12 EFE40692.1 - 0.088 12.7 3.4 3.4 7.6 2.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) ATE_C PF04377.15 EFE40693.1 - 9.1e-30 104.0 2.6 6.5e-29 101.2 2.6 2.0 1 1 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus 2C_adapt PF08793.10 EFE40693.1 - 0.19 11.9 0.4 0.58 10.4 0.3 1.8 2 0 0 2 2 2 0 2-cysteine adaptor domain MFS_1 PF07690.16 EFE40694.1 - 1.7e-40 139.1 46.2 6.2e-40 137.2 46.2 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE40694.1 - 2.3e-10 40.0 29.9 6.7e-10 38.4 7.3 3.7 2 1 1 3 3 3 3 Sugar (and other) transporter DUF4407 PF14362.6 EFE40694.1 - 6 6.1 5.5 1.7 7.9 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Fungal_trans PF04082.18 EFE40696.1 - 5.9e-05 22.2 0.5 0.0001 21.4 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF3504 PF12012.8 EFE40696.1 - 0.022 14.6 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) FAD_binding_4 PF01565.23 EFE40697.1 - 5.7e-18 65.0 1.7 1.1e-17 64.1 1.7 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE40697.1 - 1.7e-06 28.0 0.0 3.9e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like AflR PF08493.10 EFE40698.1 - 1.1e-06 28.4 6.2 1.1e-06 28.4 6.2 1.8 1 1 0 1 1 1 1 Aflatoxin regulatory protein MGC-24 PF05283.11 EFE40698.1 - 4.6 7.7 14.4 5.5 7.4 3.1 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin p450 PF00067.22 EFE40699.1 - 2.9e-25 88.9 0.0 1.2e-22 80.4 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 adh_short_C2 PF13561.6 EFE40700.1 - 7.1e-48 163.2 4.4 1.1e-39 136.4 3.3 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE40700.1 - 2.8e-45 154.2 3.2 3.6e-45 153.8 3.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE40700.1 - 4.7e-15 56.0 0.7 6.5e-15 55.5 0.7 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EFE40700.1 - 0.0044 16.9 0.5 0.0061 16.5 0.5 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EFE40700.1 - 0.035 14.2 0.5 0.097 12.7 0.5 1.7 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DDE_Tnp_1 PF01609.21 EFE40700.1 - 0.05 13.3 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 Transposase DDE domain GDP_Man_Dehyd PF16363.5 EFE40700.1 - 0.079 12.3 0.0 0.12 11.8 0.0 1.3 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFE40700.1 - 0.097 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EFE40700.1 - 0.13 11.4 0.6 0.36 9.9 0.6 1.8 1 1 0 1 1 1 0 RmlD substrate binding domain ADH_zinc_N PF00107.26 EFE40700.1 - 0.13 12.2 2.5 0.65 10.0 1.4 2.5 2 1 0 2 2 2 0 Zinc-binding dehydrogenase HlyIII PF03006.20 EFE40701.1 - 4.1e-61 206.6 13.2 5e-61 206.3 13.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related TPR_19 PF14559.6 EFE40703.1 - 0.00027 21.4 0.2 0.16 12.5 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFE40703.1 - 0.014 16.0 0.0 14 6.6 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFE40703.1 - 0.1 12.9 0.0 0.76 10.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.26 EFE40704.1 - 6.2e-35 120.5 0.0 7.5e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFE40704.1 - 8.3e-15 55.3 0.0 1e-14 55.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EFE40704.1 - 9e-07 28.6 0.0 1.3e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EFE40704.1 - 0.0012 18.3 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 UPA_2 PF17809.1 EFE40704.1 - 0.046 13.6 0.0 3.2 7.6 0.0 2.2 2 0 0 2 2 2 0 UPA domain DUF1749 PF08538.10 EFE40705.1 - 4.1e-87 292.1 0.0 4.9e-87 291.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 EFE40705.1 - 0.0001 21.6 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EFE40705.1 - 0.00084 19.2 0.1 0.026 14.4 0.0 2.9 4 0 0 4 4 4 1 Serine hydrolase Abhydrolase_3 PF07859.13 EFE40705.1 - 0.043 13.7 0.0 0.068 13.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE40705.1 - 0.056 14.0 0.0 0.098 13.2 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF908 PF06012.12 EFE40707.1 - 1.2 8.4 13.6 1.5 8.2 13.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Vps35 PF03635.17 EFE40708.1 - 2.7e-294 978.3 0.0 4.8e-168 561.0 0.0 2.0 1 1 1 2 2 2 2 Vacuolar protein sorting-associated protein 35 CobT PF06213.12 EFE40708.1 - 1.1 8.6 7.8 2.1 7.7 7.8 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NST1 PF13945.6 EFE40710.1 - 3e-79 265.6 3.3 3e-79 265.6 3.3 5.0 3 2 1 5 5 5 1 Salt tolerance down-regulator PRKCSH_1 PF13015.6 EFE40713.1 - 3.5e-31 108.0 0.4 1e-30 106.5 0.4 1.7 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH-like PF12999.7 EFE40713.1 - 3e-20 72.7 4.9 4.8e-20 72.1 2.6 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH PF07915.13 EFE40713.1 - 1.5e-09 38.7 0.7 1.5e-09 38.7 0.7 2.1 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 EFE40713.1 - 0.012 15.5 2.1 0.012 15.5 2.1 1.5 2 0 0 2 2 2 0 Autophagy-related protein 27 Arteri_nucleo PF01481.16 EFE40713.1 - 0.064 13.6 0.2 1 9.7 0.0 2.5 2 1 0 2 2 2 0 Arterivirus nucleocapsid protein DUF3450 PF11932.8 EFE40713.1 - 0.08 12.2 13.2 0.46 9.7 10.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) DUF1985 PF09331.11 EFE40713.1 - 0.091 12.8 0.2 0.19 11.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1985) HMG_box PF00505.19 EFE40713.1 - 0.1 13.0 2.6 0.24 11.8 2.6 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box Ax_dynein_light PF10211.9 EFE40713.1 - 0.76 9.7 14.5 0.091 12.7 9.9 1.9 2 0 0 2 2 2 0 Axonemal dynein light chain CorA PF01544.18 EFE40713.1 - 1.2 8.4 4.1 2.2 7.5 4.1 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4407 PF14362.6 EFE40713.1 - 2.8 7.2 14.2 0.46 9.8 10.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 EFE40713.1 - 4.9 7.2 11.0 8.3 6.4 2.5 2.8 3 0 0 3 3 3 0 Laminin Domain II Spc24 PF08286.11 EFE40713.1 - 5.4 7.3 7.4 7.5 6.8 2.6 2.7 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 DUF3584 PF12128.8 EFE40713.1 - 8.7 3.7 16.6 1.1 6.7 12.7 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Rtf2 PF04641.12 EFE40714.1 - 3.8e-65 219.9 1.1 4.7e-65 219.5 1.1 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 EFE40714.1 - 2.4e-09 36.8 0.1 0.00057 19.7 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EFE40714.1 - 0.00063 19.7 0.4 0.0029 17.6 0.0 2.3 2 1 0 2 2 2 1 RING-type zinc-finger zf-NOSIP PF15906.5 EFE40714.1 - 0.00097 19.2 0.0 0.002 18.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_5 PF14634.6 EFE40714.1 - 0.0091 15.9 0.2 0.018 15.0 0.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFE40714.1 - 0.035 14.0 0.1 0.082 12.8 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFE40714.1 - 0.061 13.2 0.7 0.64 9.9 0.3 2.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFE40714.1 - 0.17 12.3 0.9 0.27 11.6 0.2 1.7 2 0 0 2 2 2 0 Ring finger domain Ribosomal_L50 PF10501.9 EFE40715.1 - 4e-18 65.6 0.0 8.1e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal subunit 39S SAP PF02037.27 EFE40715.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 SAP domain DUF2458 PF10454.9 EFE40717.1 - 4.4e-50 169.7 2.5 5.3e-50 169.4 2.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) FAD_binding_2 PF00890.24 EFE40717.1 - 0.049 12.7 0.0 0.056 12.5 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain DUF2951 PF11166.8 EFE40717.1 - 0.089 13.0 1.5 0.13 12.5 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DAHP_synth_1 PF00793.20 EFE40718.1 - 1.3e-101 339.1 0.0 1.5e-101 338.9 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Pex24p PF06398.11 EFE40721.1 - 2.2e-86 290.1 0.1 2.6e-86 289.9 0.1 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Pam16 PF03656.13 EFE40722.1 - 5.4e-36 123.4 0.2 6.5e-36 123.1 0.2 1.0 1 0 0 1 1 1 1 Pam16 Methyltransf_23 PF13489.6 EFE40723.1 - 6.9e-11 42.2 0.0 8.8e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE40723.1 - 1.1e-08 35.5 0.0 5.2e-08 33.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE40723.1 - 1.3e-08 35.4 0.0 2.4e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE40723.1 - 2.4e-08 34.6 0.0 4.1e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE40723.1 - 2.2e-05 24.3 0.0 2.9e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain KR PF08659.10 EFE40723.1 - 0.00027 20.9 0.1 0.0005 20.0 0.1 1.5 1 1 0 1 1 1 1 KR domain MTS PF05175.14 EFE40723.1 - 0.021 14.4 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TPMT PF05724.11 EFE40723.1 - 0.059 13.0 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) YdfA_immunity PF12127.8 EFE40723.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 SigmaW regulon antibacterial DREV PF05219.12 EFE40723.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase FAT PF02259.23 EFE40725.1 - 6e-131 436.8 0.4 6e-131 436.8 0.4 1.9 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 EFE40725.1 - 1.6e-69 234.5 0.2 3.3e-69 233.5 0.2 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 EFE40725.1 - 4.1e-68 228.4 6.8 6.9e-62 208.1 2.0 4.4 3 0 0 3 3 3 3 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EFE40725.1 - 1.2e-40 137.9 2.7 7.5e-40 135.3 0.1 3.8 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 EFE40725.1 - 8.7e-17 61.3 11.8 0.00019 21.7 0.0 9.5 8 2 1 9 9 8 3 HEAT repeats FATC PF02260.20 EFE40725.1 - 1.3e-14 53.6 0.3 4.4e-14 52.0 0.3 2.0 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 EFE40725.1 - 2.1e-14 52.4 19.2 0.0023 18.0 0.1 12.4 13 0 0 13 13 12 1 HEAT repeat HEAT_EZ PF13513.6 EFE40725.1 - 2.4e-14 53.5 12.3 0.0026 18.2 0.1 11.1 11 1 2 13 13 12 4 HEAT-like repeat Cnd1 PF12717.7 EFE40725.1 - 7.8e-09 35.8 0.3 0.66 10.0 0.0 6.5 4 2 3 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EFE40725.1 - 1.9e-07 30.1 6.7 0.015 13.8 0.1 5.3 3 2 1 4 4 4 2 Adaptin N terminal region UME PF08064.13 EFE40725.1 - 2.4e-05 24.2 7.1 7.3 6.6 0.0 7.0 6 2 0 6 6 6 1 UME (NUC010) domain CLASP_N PF12348.8 EFE40725.1 - 0.00043 19.9 0.2 20 4.7 0.0 5.2 5 1 0 5 5 5 0 CLASP N terminal MMS19_C PF12460.8 EFE40725.1 - 0.0013 18.0 12.7 0.031 13.4 0.1 4.8 4 1 0 4 4 4 2 RNAPII transcription regulator C-terminal Tti2 PF10521.9 EFE40725.1 - 0.0024 17.5 1.1 5.8 6.4 0.0 4.7 3 1 3 6 6 6 1 Tti2 family IFRD PF05004.13 EFE40725.1 - 0.022 13.9 0.3 0.69 9.0 0.0 3.2 2 1 0 2 2 2 0 Interferon-related developmental regulator (IFRD) TPR_14 PF13428.6 EFE40725.1 - 0.059 14.2 9.9 3.3 8.8 0.0 5.4 4 1 1 5 5 3 0 Tetratricopeptide repeat RTP1_C1 PF10363.9 EFE40725.1 - 0.097 12.9 0.5 55 4.0 0.0 5.2 5 0 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Sec7_N PF12783.7 EFE40725.1 - 0.11 12.5 2.4 5.3 6.9 0.0 4.7 5 1 0 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_11 PF13414.6 EFE40725.1 - 0.24 11.1 3.6 2.4 7.9 0.0 3.7 3 0 0 3 3 3 0 TPR repeat TPR_19 PF14559.6 EFE40725.1 - 0.99 10.0 3.9 15 6.2 0.0 4.7 6 0 0 6 6 3 0 Tetratricopeptide repeat Mit_ribos_Mrp51 PF11709.8 EFE40726.1 - 5.9e-117 391.3 0.1 6.6e-117 391.2 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Ribosomal_S17e PF00833.18 EFE40727.1 - 7.5e-60 200.2 0.5 9e-60 200.0 0.5 1.1 1 0 0 1 1 1 1 Ribosomal S17 RPAP2_Rtr1 PF04181.13 EFE40728.1 - 3.8e-24 84.8 0.1 6.1e-24 84.1 0.1 1.3 1 0 0 1 1 1 1 Rtr1/RPAP2 family SH3_2 PF07653.17 EFE40729.1 - 3.9e-10 39.3 0.1 1.1e-09 37.8 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EFE40729.1 - 5.7e-10 38.6 0.1 1.1e-09 37.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE40729.1 - 7e-09 35.4 0.1 1.8e-08 34.1 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain Adaptin_N PF01602.20 EFE40730.1 - 3.2e-114 382.4 7.2 3.9e-114 382.1 7.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFE40730.1 - 3.6e-57 192.9 7.6 1.5e-55 187.6 1.1 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFE40730.1 - 5.7e-14 52.3 6.5 1.3e-08 35.1 0.4 4.6 4 1 1 5 5 5 4 HEAT repeats HEAT PF02985.22 EFE40730.1 - 1.4e-10 40.5 4.6 0.021 15.1 0.0 5.7 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 EFE40730.1 - 0.00026 21.4 7.2 0.88 10.1 0.1 5.8 6 1 1 7 7 7 2 HEAT-like repeat Arm PF00514.23 EFE40730.1 - 0.0006 19.8 4.6 3.9 7.6 0.0 5.5 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 EFE40730.1 - 0.00081 19.4 0.1 16 5.6 0.0 4.4 3 1 1 4 4 4 2 Spinocerebellar ataxia type 10 protein domain CLASP_N PF12348.8 EFE40730.1 - 0.0022 17.6 1.9 2.2 7.8 0.0 3.2 2 1 0 3 3 3 2 CLASP N terminal Importin_rep_4 PF18808.1 EFE40730.1 - 0.12 12.7 0.1 12 6.2 0.0 3.5 3 0 0 3 3 3 0 Importin repeat Methyltransf_2 PF00891.18 EFE40732.1 - 0.00015 21.2 0.0 0.00017 21.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain DUF1077 PF06417.12 EFE40733.1 - 1.8e-42 144.1 4.1 2.1e-42 143.8 4.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Aminotran_5 PF00266.19 EFE40734.1 - 6.6e-08 31.9 0.0 2.6e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFE40734.1 - 0.0013 18.1 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF1788 PF08747.11 EFE40734.1 - 0.068 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1788) Hemerythrin PF01814.23 EFE40736.1 - 8.3e-12 45.9 1.2 9.1e-12 45.7 0.5 1.4 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain UvrD_C PF13361.6 EFE40736.1 - 0.043 13.2 0.2 0.049 13.0 0.2 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain NTF2 PF02136.20 EFE40737.1 - 1.9e-28 99.5 0.1 6.2e-26 91.3 0.1 2.0 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Surp PF01805.20 EFE40738.1 - 1.1e-08 34.9 0.0 2.3e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Surp module Lactamase_B PF00753.27 EFE40738.1 - 0.096 12.7 0.3 0.24 11.4 0.0 1.7 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily DUF1765 PF08578.10 EFE40739.1 - 4.2e-42 143.5 1.0 8.9e-42 142.5 1.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) ATP_sub_h PF10775.9 EFE40740.1 - 4.3e-22 77.9 3.1 7.9e-22 77.0 3.1 1.5 1 0 0 1 1 1 1 ATP synthase complex subunit h TFIIB PF00382.19 EFE40741.1 - 1.6e-37 127.4 0.0 1.5e-19 69.8 0.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EFE40741.1 - 1.3e-10 40.6 0.9 1.3e-10 40.6 0.9 1.8 2 0 0 2 2 2 1 TFIIB zinc-binding RB_B PF01857.20 EFE40741.1 - 0.00029 20.9 0.0 0.00052 20.1 0.0 1.3 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Cyclin_C PF02984.19 EFE40741.1 - 0.05 13.7 0.0 2.7 8.1 0.0 2.4 2 1 0 2 2 2 0 Cyclin, C-terminal domain DUF1610 PF07754.11 EFE40741.1 - 0.24 11.4 2.4 1.1 9.3 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) TFR_dimer PF04253.15 EFE40742.1 - 5.7e-32 110.4 0.0 1e-31 109.5 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EFE40742.1 - 2.2e-16 60.2 0.0 4.8e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EFE40742.1 - 4.7e-14 52.2 0.1 1e-13 51.1 0.1 1.6 1 0 0 1 1 1 1 PA domain HMG_CoA_synt_C PF08540.10 EFE40743.1 - 1.1e-103 346.8 0.2 1.3e-103 346.5 0.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EFE40743.1 - 3.9e-96 319.9 0.1 6.2e-96 319.2 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal GFO_IDH_MocA PF01408.22 EFE40745.1 - 1.2e-10 42.3 0.0 2.3e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EFE40745.1 - 0.011 15.8 0.0 0.026 14.6 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain PGM_PMM_III PF02880.16 EFE40746.1 - 8.6e-26 90.4 0.0 1.5e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_I PF02878.16 EFE40746.1 - 2e-20 72.9 0.5 3.7e-18 65.6 0.5 2.3 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EFE40746.1 - 6.9e-17 62.0 0.0 1.8e-16 60.6 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EFE40746.1 - 1.3e-09 38.1 0.0 3.1e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RNase_T PF00929.24 EFE40748.1 - 4.6e-20 72.8 0.0 5.2e-20 72.6 0.0 1.0 1 0 0 1 1 1 1 Exonuclease PDR_CDR PF06422.12 EFE40749.1 - 0.52 10.2 1.9 1.2 9.1 1.9 1.6 1 0 0 1 1 1 0 CDR ABC transporter Popeye PF04831.13 EFE40749.1 - 6.2 7.0 6.9 1.6 8.9 3.0 1.9 2 0 0 2 2 2 0 Popeye protein conserved region Sugar_tr PF00083.24 EFE40751.1 - 9.8e-83 278.5 26.3 3.9e-69 233.7 16.5 2.6 1 1 2 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 EFE40751.1 - 2.6e-12 46.4 29.7 1.2e-08 34.3 15.3 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily Peptidase_S32 PF05579.13 EFE40752.1 - 0.13 11.4 0.1 0.66 9.1 0.0 1.8 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Piwi PF02171.17 EFE40754.1 - 1e-62 212.1 0.0 2.2e-62 211.0 0.0 1.5 2 0 0 2 2 2 1 Piwi domain ArgoN PF16486.5 EFE40754.1 - 2.3e-21 76.9 0.1 6.7e-21 75.4 0.1 1.9 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.22 EFE40754.1 - 1.9e-13 50.4 0.4 4.2e-13 49.3 0.4 1.6 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EFE40754.1 - 1e-10 41.7 0.0 2.6e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 EFE40754.1 - 7.5e-10 39.0 0.1 1.8e-09 37.8 0.1 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoL1 PF08699.10 EFE40754.1 - 1.1e-05 25.0 0.9 0.00015 21.3 0.0 2.5 2 0 0 2 2 2 1 Argonaute linker 1 domain NAP PF00956.18 EFE40754.1 - 0.098 11.8 0.2 0.17 11.0 0.2 1.3 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) Y_phosphatase PF00102.27 EFE40755.1 - 5.8e-40 137.3 0.0 9.9e-25 87.5 0.0 2.1 1 1 1 2 2 2 2 Protein-tyrosine phosphatase PPP4R2 PF09184.11 EFE40755.1 - 0.052 13.1 13.0 0.065 12.8 13.0 1.2 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.14 EFE40755.1 - 0.16 10.2 8.1 0.18 10.1 8.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFE40755.1 - 3.4 5.8 20.0 4 5.5 20.0 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EFE40755.1 - 5.7 6.3 20.1 7.3 5.9 20.1 1.1 1 0 0 1 1 1 0 SDA1 DUF4746 PF15928.5 EFE40755.1 - 5.9 6.2 15.7 1.4 8.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) VanZ PF04892.12 EFE40756.1 - 1.9e-08 35.0 0.9 3.1e-08 34.3 0.8 1.4 1 1 0 1 1 1 1 VanZ like family Phage_holin_2_4 PF16082.5 EFE40756.1 - 0.7 9.7 0.0 0.7 9.7 0.0 2.3 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like DUF4131 PF13567.6 EFE40756.1 - 3.5 7.3 7.6 4.3 7.0 2.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) Bromodomain PF00439.25 EFE40757.1 - 1.1e-17 63.9 0.2 2.6e-17 62.6 0.2 1.6 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 EFE40757.1 - 1.8e-08 34.3 0.0 5.1e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Bromodomain associated NADH_Oxid_Nqo15 PF11497.8 EFE40757.1 - 0.078 13.0 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 NADH-quinone oxidoreductase chain 15 HEPN_Swt1 PF18731.1 EFE40757.1 - 2.9 8.2 5.0 0.48 10.8 0.3 2.2 2 1 1 3 3 3 0 Swt1-like HEPN DUF3947 PF13135.6 EFE40757.1 - 4.4 7.6 6.9 9.3 6.5 6.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) TPP_enzyme_M PF00205.22 EFE40758.1 - 1.3e-20 73.5 0.0 3.1e-20 72.3 0.0 1.7 1 1 1 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.18 EFE40758.1 - 2.4e-19 69.6 0.0 3.3e-17 62.6 0.0 2.2 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EFE40758.1 - 9.4e-12 45.0 0.0 2.2e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain THUMP PF02926.17 EFE40759.1 - 2.3e-08 34.3 0.0 5.7e-08 33.0 0.0 1.5 1 1 0 1 1 1 1 THUMP domain APH PF01636.23 EFE40760.1 - 2e-05 24.7 0.0 2.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Lgl_C PF08596.10 EFE40761.1 - 6.6e-122 407.0 0.0 1.4e-121 406.0 0.0 1.5 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 EFE40761.1 - 0.0054 17.6 2.7 2.2 9.3 0.1 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat Fe-S_biosyn PF01521.20 EFE40763.1 - 4.7e-10 39.6 0.0 1.9e-08 34.5 0.0 2.0 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis Paf67 PF10255.9 EFE40764.1 - 5.7e-159 529.4 0.0 6.7e-159 529.2 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EFE40764.1 - 0.026 14.6 0.0 0.16 12.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TRAPPC-Trs85 PF12739.7 EFE40764.1 - 0.082 11.9 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit RRM_occluded PF16842.5 EFE40765.1 - 0.0023 17.7 0.2 0.0054 16.6 0.0 1.6 2 0 0 2 2 2 1 Occluded RNA-recognition motif CDH-cyt PF16010.5 EFE40766.1 - 2e-25 89.6 0.1 3.2e-25 88.9 0.1 1.2 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 EFE40766.1 - 1.2e-07 32.0 12.0 1.2e-07 32.0 12.0 1.6 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 UAA PF08449.11 EFE40766.1 - 0.063 12.5 2.2 0.07 12.3 0.6 1.8 1 1 1 2 2 2 0 UAA transporter family DOMON PF03351.17 EFE40766.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 DOMON domain PDH PF02153.17 EFE40767.1 - 3.6e-11 42.6 0.0 5e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase Ribosomal_S11 PF00411.19 EFE40769.1 - 4.7e-29 101.0 4.2 1.9e-28 99.0 4.2 1.7 1 1 0 1 1 1 1 Ribosomal protein S11 AAR2 PF05282.11 EFE40770.1 - 1.3e-95 320.8 0.0 1.5e-95 320.6 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein DUF4604 PF15377.6 EFE40770.1 - 0.48 10.8 4.2 0.26 11.7 1.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Ribosomal_S9 PF00380.19 EFE40771.1 - 1.8e-31 109.2 0.2 2e-31 109.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13 PF00572.18 EFE40772.1 - 1.2e-35 122.5 0.1 1.5e-35 122.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 PDZ_6 PF17820.1 EFE40772.1 - 0.015 15.1 0.0 0.088 12.7 0.0 2.0 2 0 0 2 2 2 0 PDZ domain Uricase PF01014.18 EFE40773.1 - 5.1e-74 246.7 0.8 4.4e-40 137.0 0.8 2.0 2 0 0 2 2 2 2 Uricase RICTOR_N PF14664.6 EFE40774.1 - 1e-128 429.5 0.2 1.9e-128 428.6 0.2 1.5 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.6 EFE40774.1 - 3.6e-38 130.3 0.1 2.9e-36 124.1 0.0 3.6 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 EFE40774.1 - 9.6e-37 124.9 2.4 6.1e-34 115.9 0.2 4.8 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EFE40774.1 - 2.9e-29 101.1 1.8 1.5e-26 92.4 0.1 4.3 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 EFE40774.1 - 3e-14 52.9 10.5 9.1e-14 51.3 10.5 1.9 1 0 0 1 1 1 1 Hr1 repeat DLP_helical PF18709.1 EFE40774.1 - 0.026 13.7 2.3 0.055 12.7 2.3 1.4 1 0 0 1 1 1 0 Dynamin-like helical domain Arm PF00514.23 EFE40774.1 - 5.8 7.1 7.2 52 4.1 0.1 4.1 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat LON_substr_bdg PF02190.16 EFE40775.1 - 2.8e-21 76.4 0.0 4.1e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 EFE40775.1 - 1.2e-11 44.2 21.0 4.1e-11 42.5 8.6 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE40775.1 - 3.9e-11 42.8 27.5 1.3e-08 34.8 2.7 3.6 3 0 0 3 3 3 2 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFE40775.1 - 3.1e-09 36.8 23.4 3.5e-05 23.9 9.1 3.1 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EFE40775.1 - 1.7e-08 34.2 19.7 2.7e-07 30.3 7.0 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFE40775.1 - 2.3e-08 34.3 7.7 2.3e-08 34.3 7.7 2.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EFE40775.1 - 4.4e-08 33.0 23.3 1e-06 28.6 7.2 2.6 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4 PF00097.25 EFE40775.1 - 7.2e-08 32.2 21.0 9.5e-07 28.6 8.2 2.9 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 EFE40775.1 - 8e-05 22.7 7.0 8e-05 22.7 7.0 2.6 2 0 0 2 2 2 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 EFE40775.1 - 0.00017 21.3 6.7 0.00017 21.3 6.7 2.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-P11 PF03854.14 EFE40775.1 - 0.00083 19.0 6.9 0.00083 19.0 6.9 2.9 4 0 0 4 4 3 1 P-11 zinc finger zf-rbx1 PF12678.7 EFE40775.1 - 0.0026 18.0 3.2 0.0026 18.0 3.2 2.9 2 1 1 3 3 2 1 RING-H2 zinc finger domain U-box PF04564.15 EFE40775.1 - 0.007 16.5 0.8 0.032 14.4 0.2 2.3 2 0 0 2 2 2 1 U-box domain zf-RING_6 PF14835.6 EFE40775.1 - 0.021 14.7 11.8 0.13 12.2 2.4 2.6 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EFE40775.1 - 1.6 8.6 18.9 0.035 13.9 6.2 3.4 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF1272 PF06906.11 EFE40775.1 - 3.7 7.7 14.7 0.22 11.7 5.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) Paf1 PF03985.13 EFE40776.1 - 2.6e-57 194.7 0.0 3.7e-57 194.2 0.0 1.2 1 0 0 1 1 1 1 Paf1 Actin PF00022.19 EFE40777.1 - 2.5e-26 92.3 0.0 2.4e-15 56.1 0.0 2.6 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EFE40777.1 - 2.2e-05 23.5 0.0 0.018 13.9 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Actin_micro PF17003.5 EFE40777.1 - 0.0002 20.7 0.6 0.37 9.9 0.1 2.9 3 0 0 3 3 3 2 Putative actin-like family FtsA PF14450.6 EFE40777.1 - 0.11 13.0 0.0 0.27 11.7 0.0 1.8 1 1 0 1 1 1 0 Cell division protein FtsA Arf PF00025.21 EFE40778.1 - 5.7e-73 244.1 0.0 6.9e-73 243.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFE40778.1 - 6.8e-14 52.1 0.0 9.1e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFE40778.1 - 1.9e-11 43.7 0.0 2.4e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFE40778.1 - 3e-10 39.8 0.3 3.9e-06 26.3 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFE40778.1 - 1.4e-09 37.8 0.0 1.8e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFE40778.1 - 3.2e-08 33.2 0.0 4.1e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFE40778.1 - 2.7e-06 27.4 0.0 4.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFE40778.1 - 0.0026 17.3 0.0 0.2 11.2 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFE40778.1 - 0.0074 15.8 0.4 0.031 13.8 0.4 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 EFE40778.1 - 0.15 12.6 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Glyco_hydro_72 PF03198.14 EFE40779.1 - 1.1e-122 409.2 4.0 1.4e-122 408.9 4.0 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EFE40779.1 - 1.8e-06 27.6 0.4 1.7e-05 24.4 0.4 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SH3_9 PF14604.6 EFE40780.1 - 5.2e-20 71.0 1.2 1.1e-10 41.1 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 EFE40780.1 - 9.3e-19 67.5 1.7 1.4e-18 67.0 0.1 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EFE40780.1 - 9.4e-17 60.4 0.4 2.9e-08 33.2 0.0 2.4 2 0 0 2 2 2 2 SH3 domain C1_1 PF00130.22 EFE40780.1 - 1.1e-15 57.2 5.2 1.8e-15 56.6 5.2 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_2 PF07653.17 EFE40780.1 - 3.9e-06 26.5 0.1 0.00059 19.5 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.11 EFE40780.1 - 0.0099 16.1 0.5 0.079 13.2 0.1 2.3 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_10 PF17902.1 EFE40780.1 - 0.027 14.5 0.0 1.9 8.6 0.0 2.7 2 0 0 2 2 2 0 SH3 domain C1_2 PF03107.16 EFE40780.1 - 0.046 14.0 5.3 0.087 13.2 5.3 1.4 1 0 0 1 1 1 0 C1 domain FapA PF03961.13 EFE40780.1 - 1.2 7.7 6.0 0.29 9.7 0.8 2.3 2 0 0 2 2 2 0 Flagellar Assembly Protein A DEAD PF00270.29 EFE40781.1 - 2e-35 122.1 0.4 8.8e-35 120.0 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE40781.1 - 3.4e-24 85.3 0.1 2.3e-23 82.6 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain tRNA-synt_1b PF00579.25 EFE40781.1 - 0.14 11.5 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) DAO PF01266.24 EFE40782.1 - 8.3e-37 127.6 0.0 2.1e-36 126.3 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFE40782.1 - 0.00024 20.5 0.0 0.031 13.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE40782.1 - 0.0019 17.4 0.0 0.089 11.9 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 EFE40782.1 - 0.023 14.0 0.0 0.072 12.4 0.0 1.7 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFE40782.1 - 0.027 14.7 0.0 0.071 13.4 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFE40782.1 - 0.045 13.8 0.0 0.43 10.6 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 EFE40782.1 - 0.056 12.1 0.1 6 5.4 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_2 PF07992.14 EFE40782.1 - 0.069 12.4 0.0 0.95 8.6 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_kinase PF01513.21 EFE40783.1 - 8.7e-60 202.4 0.0 9.1e-42 143.2 0.0 2.3 1 1 1 2 2 2 2 ATP-NAD kinase Pro-kuma_activ PF09286.11 EFE40784.1 - 1.4e-34 119.5 0.0 2.2e-34 118.8 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFE40784.1 - 1.7e-07 30.8 0.2 4.3e-07 29.5 0.2 1.6 1 1 0 1 1 1 1 Subtilase family E1-E2_ATPase PF00122.20 EFE40787.1 - 4.3e-41 140.4 9.4 3.5e-31 108.1 0.0 3.3 2 1 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFE40787.1 - 6.1e-27 94.5 3.3 6.1e-27 94.5 3.3 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFE40787.1 - 3.2e-18 66.8 0.2 1.1e-14 55.2 0.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE40787.1 - 1.6e-11 44.1 0.0 3.2e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFE40787.1 - 1.6e-05 24.8 1.5 1.6e-05 24.8 1.5 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 EFE40787.1 - 0.004 17.1 1.0 0.011 15.6 1.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2463) DUF2014 PF09427.10 EFE40788.1 - 6.4e-102 340.4 0.1 8.7e-102 340.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.26 EFE40788.1 - 6.2e-18 64.5 1.8 1.3e-17 63.5 1.8 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ZapB PF06005.12 EFE40788.1 - 0.11 12.9 1.1 0.17 12.3 0.3 1.6 2 0 0 2 2 2 0 Cell division protein ZapB bZIP_1 PF00170.21 EFE40788.1 - 0.57 10.3 3.5 0.54 10.4 2.0 1.7 2 0 0 2 2 2 0 bZIP transcription factor DHDPS PF00701.22 EFE40789.1 - 4e-42 143.9 0.0 4.7e-42 143.7 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Nop14 PF04147.12 EFE40790.1 - 0.05 11.8 8.0 0.08 11.1 8.0 1.2 1 0 0 1 1 1 0 Nop14-like family Ribosomal_60s PF00428.19 EFE40790.1 - 0.35 11.5 9.1 2.4 8.8 9.6 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein FAM176 PF14851.6 EFE40790.1 - 0.83 9.3 8.7 2.5 7.8 8.7 1.7 1 0 0 1 1 1 0 FAM176 family DUF4637 PF15470.6 EFE40790.1 - 1.1 9.0 9.6 2.3 8.0 9.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) TFIIA PF03153.13 EFE40790.1 - 2.9 7.8 11.9 4.3 7.2 11.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CENP-B_dimeris PF09026.10 EFE40790.1 - 2.9 8.3 16.5 6.3 7.3 14.8 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain GOLD_2 PF13897.6 EFE40790.1 - 3.4 8.2 6.5 7.6 7.0 6.5 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DNA_pol_phi PF04931.13 EFE40790.1 - 4.9 5.1 15.2 7.5 4.5 15.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_ner PF04546.13 EFE40790.1 - 5.1 6.9 11.6 2.6 7.9 8.0 2.2 3 0 0 3 3 3 0 Sigma-70, non-essential region HSP90 PF00183.18 EFE40790.1 - 5.8 5.7 7.7 9.7 5.0 7.7 1.2 1 0 0 1 1 1 0 Hsp90 protein Astro_capsid_p PF12226.8 EFE40790.1 - 7.4 5.6 8.8 16 4.5 8.8 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein MFS_1 PF07690.16 EFE40791.1 - 5.8e-35 120.8 27.0 5.8e-35 120.8 27.0 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EFE40791.1 - 3.3e-05 23.4 1.1 3.3e-05 23.4 1.1 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Chorismate_bind PF00425.18 EFE40792.1 - 1.3e-70 238.0 0.0 1.4e-46 159.1 0.0 2.3 1 1 1 2 2 2 2 chorismate binding enzyme GATase PF00117.28 EFE40792.1 - 1.2e-32 113.3 0.0 1.9e-32 112.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFE40792.1 - 1.6e-08 34.6 0.0 3.4e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 Anth_synt_I_N PF04715.13 EFE40792.1 - 7.9e-08 32.6 0.0 1.9e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Ank_2 PF12796.7 EFE40793.1 - 3.4e-26 91.6 0.0 6.2e-12 45.9 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFE40793.1 - 3.2e-21 73.1 0.5 0.00053 20.2 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 EFE40793.1 - 1.5e-18 66.6 1.2 2.4e-07 30.9 0.1 4.9 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFE40793.1 - 9.7e-17 61.1 1.5 1.1e-07 32.3 0.1 4.5 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFE40793.1 - 1e-14 54.2 4.3 0.0082 16.6 0.1 5.3 5 0 0 5 5 5 4 Ankyrin repeat DUF3447 PF11929.8 EFE40793.1 - 0.0007 19.5 0.0 0.14 12.1 0.0 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF3447) F-box-like PF12937.7 EFE40793.1 - 0.028 14.3 0.2 0.049 13.5 0.2 1.4 1 0 0 1 1 1 0 F-box-like Pneumo_att_G PF05539.11 EFE40795.1 - 4.6 6.7 8.8 5.5 6.5 8.8 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Mito_carr PF00153.27 EFE40796.1 - 6.9e-29 99.6 0.0 9.4e-16 57.5 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Anp1 PF03452.14 EFE40797.1 - 2.4e-102 341.9 0.0 3e-102 341.6 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 EFE40797.1 - 0.024 14.5 0.0 0.044 13.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Zip PF02535.22 EFE40798.1 - 3.9e-57 194.0 12.2 2.6e-56 191.2 12.2 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter Nop16 PF09420.10 EFE40799.1 - 1e-69 234.8 16.0 1.2e-69 234.6 16.0 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 DUF3283 PF11686.8 EFE40799.1 - 0.38 10.6 4.6 0.17 11.8 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3283) Pex24p PF06398.11 EFE40801.1 - 4e-71 239.9 0.0 9.3e-71 238.7 0.0 1.5 1 1 1 2 2 2 1 Integral peroxisomal membrane peroxin Pkinase PF00069.25 EFE40802.1 - 1.4e-52 178.7 0.0 1.9e-52 178.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40802.1 - 7.4e-19 68.0 0.0 1.2e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 EFE40802.1 - 0.19 11.9 0.1 0.35 11.0 0.1 1.4 1 0 0 1 1 1 0 ABC1 family COPIIcoated_ERV PF07970.12 EFE40803.1 - 3.7e-31 108.7 0.0 9.4e-31 107.4 0.0 1.6 1 1 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EFE40803.1 - 3.9e-23 81.6 0.0 6.6e-23 80.9 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Abhydrolase_6 PF12697.7 EFE40804.1 - 3.4e-17 63.8 0.0 4.4e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFE40804.1 - 0.00013 21.3 0.1 0.0014 17.9 0.1 2.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 EFE40804.1 - 0.0037 16.3 0.0 0.046 12.7 0.0 2.0 1 1 1 2 2 2 1 Chlorophyllase PGAP1 PF07819.13 EFE40804.1 - 0.13 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.13 EFE40804.1 - 0.17 11.7 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold N2227 PF07942.12 EFE40806.1 - 1.1e-61 208.5 0.0 1.4e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 EFE40806.1 - 0.019 14.8 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain KASH_CCD PF14662.6 EFE40807.1 - 0.00033 20.6 11.4 0.00033 20.6 11.4 4.5 2 1 2 5 5 5 2 Coiled-coil region of CCDC155 or KASH Filament PF00038.21 EFE40807.1 - 0.00046 19.9 19.4 0.00046 19.9 19.4 4.0 3 1 1 4 4 4 1 Intermediate filament protein MscS_porin PF12795.7 EFE40807.1 - 0.001 18.7 38.4 0.001 18.7 38.4 3.3 2 1 1 3 3 3 1 Mechanosensitive ion channel porin domain Tropomyosin_1 PF12718.7 EFE40807.1 - 0.0024 18.0 28.2 0.0024 18.0 28.2 5.3 5 1 1 6 6 6 2 Tropomyosin like NPV_P10 PF05531.12 EFE40807.1 - 0.73 10.3 15.8 1.9 9.0 0.5 4.4 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Herpes_LMP1 PF05297.11 EFE40807.1 - 4.2 6.5 5.8 7.1 5.7 5.8 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Maf1 PF09174.10 EFE40808.1 - 4.4e-64 215.8 0.0 6.2e-64 215.3 0.0 1.2 1 0 0 1 1 1 1 Maf1 regulator Clat_adaptor_s PF01217.20 EFE40809.1 - 2.3e-33 115.1 0.8 3.4e-33 114.6 0.8 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PulA_N1 PF17999.1 EFE40809.1 - 0.13 13.0 0.0 0.25 12.1 0.0 1.4 1 0 0 1 1 1 0 Pullulanase N1-terminal domain Aldo_ket_red PF00248.21 EFE40810.1 - 3.1e-14 52.9 0.0 4.4e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Kdo PF06293.14 EFE40811.1 - 9.2e-08 31.7 0.0 0.0061 15.9 0.0 3.1 3 0 0 3 3 3 3 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE40811.1 - 2.6e-07 30.8 0.0 0.01 15.8 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase PF00069.25 EFE40811.1 - 1.7e-06 27.6 0.0 2.7e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFE40811.1 - 0.011 14.6 0.0 0.014 14.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Pkinase_Tyr PF07714.17 EFE40811.1 - 0.02 14.2 0.0 0.04 13.2 0.0 1.5 2 0 0 2 2 2 0 Protein tyrosine kinase RIO1 PF01163.22 EFE40811.1 - 0.028 14.0 0.0 1.3 8.6 0.0 2.7 3 0 0 3 3 3 0 RIO1 family Metallophos PF00149.28 EFE40813.1 - 5.2e-09 36.9 0.3 7.7e-09 36.3 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STE2 PF02116.15 EFE40814.1 - 9.8e-94 313.8 28.4 1.2e-93 313.5 28.4 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR WD40 PF00400.32 EFE40815.1 - 1.8e-13 50.7 7.1 0.03 15.2 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE40815.1 - 1.5e-08 34.8 0.1 0.12 12.7 0.0 4.6 2 2 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE40815.1 - 0.025 13.6 0.4 2.7 6.9 0.0 3.0 2 2 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Vps23_core PF09454.10 EFE40816.1 - 2.2e-21 75.6 0.0 1.2e-20 73.3 0.0 2.0 2 0 0 2 2 2 1 Vps23 core domain ADIP PF11559.8 EFE40816.1 - 0.0096 16.0 0.9 0.018 15.1 0.9 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding AAA_13 PF13166.6 EFE40816.1 - 0.15 10.7 0.1 0.19 10.4 0.1 1.1 1 0 0 1 1 1 0 AAA domain DUF3450 PF11932.8 EFE40816.1 - 0.24 10.7 1.2 0.38 10.0 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Halo_GVPC PF05465.13 EFE40816.1 - 0.26 11.6 0.3 0.51 10.6 0.3 1.5 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat TPR_MLP1_2 PF07926.12 EFE40816.1 - 0.28 11.2 1.3 5.5 7.1 0.1 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein IDO PF01231.18 EFE40817.1 - 1.8e-118 396.1 0.0 2.1e-118 395.8 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase 5-nucleotidase PF06189.12 EFE40817.1 - 0.15 11.0 0.1 0.25 10.2 0.1 1.3 1 0 0 1 1 1 0 5'-nucleotidase M20_dimer PF07687.14 EFE40818.1 - 0.14 12.1 2.7 3.7 7.5 0.3 2.9 3 0 0 3 3 3 0 Peptidase dimerisation domain HAMP PF00672.25 EFE40819.1 - 2.3e-36 123.9 15.9 6.6e-08 32.8 0.5 7.9 6 2 2 8 8 8 5 HAMP domain HATPase_c PF02518.26 EFE40819.1 - 2.9e-33 114.7 0.0 1.5e-32 112.4 0.0 2.3 2 0 0 2 2 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFE40819.1 - 1e-24 86.8 1.2 6e-24 84.4 0.5 2.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EFE40819.1 - 6.7e-17 61.3 4.1 2.2e-16 59.6 0.1 3.9 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain DUF4279 PF14106.6 EFE40819.1 - 9.5e-06 25.8 0.0 3.5 7.9 0.0 5.5 5 1 0 5 5 5 1 Domain of unknown function (DUF4279) DUF3829 PF12889.7 EFE40819.1 - 0.00093 18.8 13.9 0.037 13.5 0.2 5.0 5 1 1 6 6 6 2 Protein of unknown function (DUF3829) DUF948 PF06103.11 EFE40819.1 - 0.0017 18.6 47.9 1.3 9.3 0.1 9.1 3 1 3 6 6 6 1 Bacterial protein of unknown function (DUF948) Syntaxin_2 PF14523.6 EFE40819.1 - 0.0017 18.7 15.2 5.9 7.3 0.0 6.8 3 2 3 6 6 6 1 Syntaxin-like protein NOD PF06816.13 EFE40819.1 - 0.048 13.3 0.0 6 6.6 0.0 2.7 2 0 0 2 2 2 0 NOTCH protein Fib_alpha PF08702.10 EFE40819.1 - 0.054 13.7 36.3 2.6 8.2 0.1 7.3 6 1 1 7 7 7 0 Fibrinogen alpha/beta chain family IcmF_C PF06744.12 EFE40819.1 - 0.059 13.0 0.0 0.18 11.4 0.0 1.8 1 0 0 1 1 1 0 Type VI secretion protein IcmF C-terminal Vps52 PF04129.12 EFE40819.1 - 0.063 12.0 4.4 4.8 5.8 0.2 3.8 4 0 0 4 4 4 0 Vps52 / Sac2 family SpoIIID PF12116.8 EFE40819.1 - 0.1 12.7 2.8 25 5.1 0.1 4.5 4 0 0 4 4 3 0 Stage III sporulation protein D Gp-FAR-1 PF05823.12 EFE40819.1 - 0.11 12.8 4.4 36 4.7 0.0 4.7 1 1 4 5 5 5 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) WXG100 PF06013.12 EFE40819.1 - 0.4 10.9 19.5 11 6.3 0.2 7.1 6 2 1 7 7 7 0 Proteins of 100 residues with WXG CMD PF02627.20 EFE40819.1 - 0.58 10.3 2.2 8.6 6.5 0.1 3.7 4 0 0 4 4 4 0 Carboxymuconolactone decarboxylase family DUF2877 PF11392.8 EFE40819.1 - 1.2 9.9 9.0 11 6.8 0.2 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2877) CENP-F_leu_zip PF10473.9 EFE40819.1 - 2.1 8.4 27.7 3.5 7.6 0.2 7.5 5 3 2 8 8 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-B_dimeris PF09026.10 EFE40819.1 - 2.3 8.7 9.8 5.8 7.4 9.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GhoS PF11080.8 EFE40819.1 - 3.5 7.7 7.4 4.2 7.4 0.1 3.9 4 0 0 4 4 4 0 Endoribonuclease GhoS GLE1 PF07817.13 EFE40819.1 - 3.6 6.7 11.3 20 4.3 0.4 4.3 3 1 2 5 5 5 0 GLE1-like protein AdHead_fibreRBD PF16812.5 EFE40819.1 - 3.6 7.4 11.8 0.046 13.5 0.4 3.3 4 0 0 4 4 4 0 C-terminal head domain of the fowl adenovirus type 1 long fibre MFS_1 PF07690.16 EFE40821.1 - 3.9e-28 98.4 40.6 3.9e-28 98.4 40.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE40821.1 - 1.8e-08 33.7 35.2 1.3e-05 24.3 13.7 2.3 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFE40822.1 - 5.3e-27 94.7 28.9 2.3e-18 66.3 22.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE40822.1 - 7.8e-20 71.2 15.3 3.4e-19 69.0 15.3 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter Pkinase PF00069.25 EFE40823.1 - 2.9e-69 233.4 0.0 5.8e-69 232.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40823.1 - 2.3e-34 118.9 0.0 1.9e-33 115.8 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE40823.1 - 0.0011 18.3 0.4 0.69 9.2 0.0 2.6 3 0 0 3 3 3 2 Kinase-like RIO1 PF01163.22 EFE40823.1 - 0.058 13.0 0.2 0.13 11.9 0.2 1.6 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EFE40823.1 - 0.34 9.6 0.0 0.34 9.6 0.0 2.2 3 0 0 3 3 3 0 Fungal protein kinase Fungal_trans PF04082.18 EFE40826.1 - 3.7e-07 29.5 0.3 6.1e-07 28.7 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3573 PF12097.8 EFE40826.1 - 0.049 12.5 0.1 0.078 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) SUIM_assoc PF16619.5 EFE40826.1 - 1.5 9.0 9.0 0.15 12.1 3.2 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 WD40 PF00400.32 EFE40827.1 - 0.0078 17.1 0.1 17 6.5 0.1 4.7 5 0 0 5 5 5 1 WD domain, G-beta repeat EspF PF04806.12 EFE40827.1 - 6.4 7.3 20.4 0.088 13.2 2.5 3.8 3 0 0 3 3 3 0 EspF protein repeat PI-PLC-X PF00388.19 EFE40828.1 - 1.4e-41 141.5 0.0 2.8e-41 140.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EFE40828.1 - 6.1e-37 126.5 0.0 8.5e-36 122.8 0.1 2.3 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain PI-PLC-X PF00388.19 EFE40829.1 - 3.1e-12 46.3 0.2 4.7e-12 45.7 0.2 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain zf_C2H2_13 PF18508.1 EFE40830.1 - 0.023 14.3 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 Zinc finger domain GST_C PF00043.25 EFE40831.1 - 9.2e-09 35.4 0.0 1.5e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFE40831.1 - 4e-08 33.5 0.0 6.7e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFE40831.1 - 4.6e-05 23.5 0.0 7.5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFE40831.1 - 0.00012 22.5 0.0 0.00023 21.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFE40831.1 - 0.0021 18.0 0.0 0.0045 17.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFE40831.1 - 0.013 15.8 0.0 0.027 14.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain ERO1 PF04137.15 EFE40832.1 - 7e-134 446.5 0.0 1e-133 445.9 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) TPP_enzyme_N PF02776.18 EFE40833.1 - 2.4e-44 150.9 0.1 4.9e-44 150.0 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EFE40833.1 - 2.3e-34 118.1 0.0 4.1e-34 117.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EFE40833.1 - 3.9e-18 65.7 0.0 8.8e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain B12-binding PF02310.19 EFE40833.1 - 0.0085 16.1 0.2 0.032 14.3 0.2 2.0 1 0 0 1 1 1 1 B12 binding domain CO_dh PF02552.16 EFE40833.1 - 0.037 13.8 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit TPR_1 PF00515.28 EFE40834.1 - 1.1e-26 91.5 1.8 2.7e-09 36.4 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFE40834.1 - 1e-24 84.6 2.6 1.4e-07 31.0 0.0 6.0 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFE40834.1 - 1.2e-19 69.7 3.9 1.8e-08 33.9 0.0 4.9 4 1 1 5 5 5 3 TPR repeat TPR_16 PF13432.6 EFE40834.1 - 2.2e-19 69.8 0.8 1.7e-05 25.3 0.0 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFE40834.1 - 3.2e-18 64.8 2.2 3.5e-05 24.3 0.0 5.7 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFE40834.1 - 2.4e-16 58.5 0.1 7.3e-07 28.9 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFE40834.1 - 8.8e-16 58.2 2.3 0.00028 21.3 0.0 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFE40834.1 - 1.2e-15 56.7 1.7 0.0028 17.9 0.1 5.0 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_20 PF14561.6 EFE40834.1 - 1.4e-10 41.3 0.4 0.0057 16.9 0.0 4.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFE40834.1 - 2.1e-10 39.9 2.0 0.0071 16.3 0.0 6.2 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFE40834.1 - 2.6e-10 40.3 0.6 0.0041 17.2 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE40834.1 - 3.8e-10 39.9 4.5 8.6e-06 26.0 0.3 4.1 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFE40834.1 - 1.6e-07 31.5 1.1 2.4 9.0 0.0 6.0 6 0 0 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE40834.1 - 5.6e-06 26.5 1.3 0.0026 18.0 0.1 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EFE40834.1 - 0.00024 20.4 0.4 0.29 10.3 0.4 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_3 PF07720.12 EFE40834.1 - 0.0025 17.8 0.1 4.3 7.4 0.0 3.2 4 0 0 4 4 3 1 Tetratricopeptide repeat MIT PF04212.18 EFE40834.1 - 0.0066 16.5 0.5 10 6.3 0.1 4.2 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 EFE40834.1 - 0.013 15.3 4.1 0.084 12.8 0.3 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4192 PF13830.6 EFE40834.1 - 0.034 14.2 4.3 0.041 13.9 2.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4192) TOM20_plant PF06552.12 EFE40834.1 - 0.07 12.9 0.1 4.8 6.9 0.0 3.0 3 1 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 DUF1641 PF07849.11 EFE40834.1 - 0.12 12.3 0.2 0.24 11.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) NatB_MDM20 PF09797.9 EFE40834.1 - 0.21 10.5 0.0 0.37 9.7 0.0 1.4 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit RRM_1 PF00076.22 EFE40835.1 - 2.5e-32 110.5 0.0 6.2e-18 64.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFE40835.1 - 0.046 13.8 0.5 0.14 12.2 0.0 2.1 3 0 0 3 3 3 0 RNA binding motif RRM_7 PF16367.5 EFE40835.1 - 0.1 12.7 0.0 8.5 6.6 0.0 2.6 2 1 0 2 2 2 0 RNA recognition motif AID PF18767.1 EFE40835.1 - 0.18 11.8 0.0 4.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Activation induced deaminase Fungal_trans PF04082.18 EFE40836.1 - 2.6e-09 36.5 0.1 5.9e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain HSBP1 PF06825.12 EFE40836.1 - 0.014 15.2 0.4 0.027 14.3 0.4 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 SnoaL PF07366.12 EFE40837.1 - 0.011 15.6 0.4 0.31 10.8 0.0 2.9 2 1 0 2 2 2 0 SnoaL-like polyketide cyclase SHS2_Rpb7-N PF03876.17 EFE40838.1 - 1.4e-14 54.2 0.1 1.7e-14 53.9 0.1 1.1 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DUF962 PF06127.11 EFE40839.1 - 1.2e-14 54.1 4.6 3.7e-14 52.6 4.6 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF962) ATP-synt_ab PF00006.25 EFE40841.1 - 2.6e-73 246.2 0.0 3.5e-73 245.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EFE40841.1 - 1.5e-47 161.1 0.2 2.4e-47 160.4 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EFE40841.1 - 4e-12 46.5 1.2 9.6e-12 45.3 1.2 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF3659 PF12396.8 EFE40841.1 - 0.11 12.5 0.6 19 5.2 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3659) THF_DHG_CYH PF00763.23 EFE40842.1 - 8.1e-26 90.6 0.0 1.3e-25 90.0 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EFE40842.1 - 9.4e-14 51.0 0.0 3.6e-09 36.1 0.0 2.7 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Fer2_BFD PF04324.15 EFE40842.1 - 0.071 13.5 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 BFD-like [2Fe-2S] binding domain SPC25 PF06703.11 EFE40843.1 - 1e-12 48.1 0.3 1.2e-12 47.9 0.3 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) EMC3_TMCO1 PF01956.16 EFE40844.1 - 9.8e-45 152.3 0.1 1.3e-44 152.0 0.1 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Fasciclin PF02469.22 EFE40845.1 - 0.0048 17.1 0.0 0.0094 16.2 0.0 1.5 1 1 0 1 1 1 1 Fasciclin domain MMS19_N PF14500.6 EFE40846.1 - 7.7e-16 58.5 0.0 1.2e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 EFE40846.1 - 0.073 13.5 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 HEAT repeats MMS19_C PF12460.8 EFE40847.1 - 5e-118 394.9 12.9 5e-118 394.9 12.9 3.5 2 2 1 3 3 3 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EFE40847.1 - 2.9e-43 148.4 0.8 1.3e-40 139.7 0.1 4.1 4 1 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 EFE40847.1 - 0.0041 17.5 2.7 2.7 8.5 0.4 4.4 4 1 0 4 4 4 1 HEAT repeats CLASP_N PF12348.8 EFE40847.1 - 0.96 9.0 7.5 0.55 9.8 1.7 3.3 3 1 0 3 3 3 0 CLASP N terminal HEAT PF02985.22 EFE40847.1 - 3.2 8.3 10.4 33 5.1 0.3 4.9 5 0 0 5 5 5 0 HEAT repeat SHE3 PF17078.5 EFE40849.1 - 8.5e-09 35.5 28.7 2.8e-08 33.7 21.2 2.0 1 1 0 2 2 2 2 SWI5-dependent HO expression protein 3 HSCB_C PF07743.13 EFE40849.1 - 0.033 14.7 2.1 0.033 14.7 2.1 3.9 1 1 3 4 4 4 0 HSCB C-terminal oligomerisation domain KASH_CCD PF14662.6 EFE40849.1 - 0.037 13.8 30.5 0.71 9.7 18.6 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH ATG16 PF08614.11 EFE40849.1 - 0.24 11.6 39.0 3.6 7.8 23.2 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Peroxin-13_N PF04088.13 EFE40850.1 - 1e-53 181.5 0.1 2e-53 180.6 0.1 1.5 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 EFE40850.1 - 4.1e-09 36.0 0.0 7.7e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFE40850.1 - 3e-07 29.9 0.0 5.6e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE40850.1 - 5.6e-06 26.1 0.1 9.8e-06 25.3 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.6 EFE40850.1 - 0.17 12.3 0.0 0.32 11.4 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain LAMTOR PF15454.6 EFE40850.1 - 1 10.0 4.5 1.1 9.9 0.2 2.5 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Aminotran_5 PF00266.19 EFE40851.1 - 1.4e-27 96.6 0.0 2e-27 96.1 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V APG6 PF04111.12 EFE40852.1 - 7.1e-73 244.4 0.0 1.1e-72 243.8 0.0 1.3 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EFE40852.1 - 6.3e-39 133.6 10.7 1.1e-38 132.8 10.7 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region YabA PF06156.13 EFE40852.1 - 0.12 13.0 1.5 0.3 11.7 1.5 1.7 1 0 0 1 1 1 0 Initiation control protein YabA Jnk-SapK_ap_N PF09744.9 EFE40852.1 - 4.7 7.4 11.8 10 6.4 11.8 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Scm3 PF10384.9 EFE40853.1 - 4.5e-21 74.4 0.1 7.8e-21 73.6 0.1 1.4 1 0 0 1 1 1 1 Centromere protein Scm3 Myb_DNA-binding PF00249.31 EFE40853.1 - 9.1e-06 25.8 0.2 0.4 10.9 0.1 3.3 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFE40853.1 - 1.5e-05 25.1 1.8 0.13 12.6 1.1 2.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain PALP PF00291.25 EFE40854.1 - 1.8e-42 145.8 2.2 2.8e-37 128.7 1.3 3.1 2 1 1 3 3 3 2 Pyridoxal-phosphate dependent enzyme Methyltransf_28 PF02636.17 EFE40855.1 - 1.3e-34 120.1 0.0 5.7e-34 117.9 0.0 1.8 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Pal1 PF08316.11 EFE40856.1 - 3.7e-08 34.2 0.0 6.9e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Pal1 cell morphology protein Terpene_synth_C PF03936.16 EFE40857.1 - 1.5e-06 27.7 0.0 2.7e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain HVSL PF09749.9 EFE40858.1 - 1.2e-68 231.1 0.0 4e-55 186.9 0.0 2.1 1 1 1 2 2 2 2 Uncharacterised conserved protein DUF3807 PF12720.7 EFE40859.1 - 3.5e-43 148.0 1.8 4.5e-43 147.6 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3807) EPL1 PF10513.9 EFE40859.1 - 0.22 11.9 5.0 0.3 11.5 5.0 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like PCEMA1 PF07418.11 EFE40860.1 - 0.0056 16.3 0.1 0.0061 16.1 0.1 1.0 1 0 0 1 1 1 1 Acidic phosphoprotein precursor PCEMA1 YvrJ PF12841.7 EFE40860.1 - 0.63 9.6 0.2 0.63 9.6 0.2 1.6 2 0 0 2 2 2 0 YvrJ protein family CTP_transf_like PF01467.26 EFE40863.1 - 9.1e-30 103.7 0.0 1.7e-29 102.8 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like HIGH_NTase1 PF05636.11 EFE40863.1 - 0.09 12.0 0.2 0.28 10.4 0.0 1.8 2 0 0 2 2 2 0 HIGH Nucleotidyl Transferase IHABP4_N PF16174.5 EFE40863.1 - 2.4 8.7 13.3 8.1 7.0 11.0 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Wbp11 PF09429.10 EFE40864.1 - 0.15 12.5 3.0 0.27 11.7 3.0 1.5 1 1 0 1 1 1 0 WW domain binding protein 11 EamA PF00892.20 EFE40865.1 - 2.9e-11 43.7 12.0 1.9e-08 34.6 11.7 2.9 2 1 1 3 3 3 2 EamA-like transporter family PEP-CTERM PF07589.11 EFE40865.1 - 0.0011 19.0 3.7 0.56 10.4 0.0 3.5 3 0 0 3 3 3 2 PEP-CTERM motif Trp_oprn_chp PF09534.10 EFE40865.1 - 0.14 12.0 2.3 3.3 7.5 0.8 2.3 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3341 PF11821.8 EFE40865.1 - 0.61 9.7 2.5 4.9 6.8 0.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3341) UTP25 PF06862.12 EFE40866.1 - 3.5e-189 629.5 0.0 4.2e-189 629.2 0.0 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 EFE40866.1 - 0.00026 20.8 0.0 0.41 10.4 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase JAB PF01398.21 EFE40867.1 - 5.6e-20 71.5 0.0 9.8e-20 70.7 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EFE40867.1 - 1.5e-18 67.3 0.2 2.7e-18 66.4 0.2 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 EFE40867.1 - 8.6e-05 22.7 0.0 0.0002 21.5 0.0 1.5 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0172) TFIID-18kDa PF02269.16 EFE40868.1 - 2.5e-23 81.9 0.0 3.8e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TFIID_20kDa PF03847.13 EFE40868.1 - 0.01 16.3 0.1 0.021 15.3 0.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A CENP-S PF15630.6 EFE40868.1 - 0.078 13.4 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 CENP-S protein Histone PF00125.24 EFE40868.1 - 0.083 13.2 0.1 0.21 12.0 0.0 1.7 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 PPR_2 PF13041.6 EFE40870.1 - 2.4e-22 78.8 0.2 3.4e-10 39.9 0.0 4.9 4 1 1 5 5 5 3 PPR repeat family PPR PF01535.20 EFE40870.1 - 5.1e-14 51.5 0.1 0.00046 20.2 0.0 4.8 5 0 0 5 5 5 3 PPR repeat PPR_1 PF12854.7 EFE40870.1 - 1.3e-08 34.4 0.0 0.0013 18.4 0.0 4.0 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.6 EFE40870.1 - 1.9e-08 34.2 0.0 0.0044 17.1 0.0 3.3 2 1 1 3 3 3 3 Pentatricopeptide repeat domain PPR_long PF17177.4 EFE40870.1 - 3.6e-07 29.8 0.0 0.00043 19.7 0.0 2.6 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP cwf18 PF08315.12 EFE40871.1 - 1.2e-44 152.2 8.9 2.3e-44 151.4 8.9 1.5 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor KicB PF03882.14 EFE40871.1 - 0.025 14.8 0.3 0.065 13.5 0.2 1.8 2 0 0 2 2 2 0 MukF winged-helix domain SUZ PF12752.7 EFE40873.1 - 4.5e-13 49.8 12.3 4.5e-13 49.8 12.3 4.3 3 1 0 3 3 3 1 SUZ domain RRM_1 PF00076.22 EFE40874.1 - 1.6e-07 31.0 0.0 2.6e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spc7 PF08317.11 EFE40874.1 - 0.0075 15.2 2.2 0.0081 15.1 2.2 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein EMP24_GP25L PF01105.24 EFE40874.1 - 0.016 15.2 0.8 0.02 14.9 0.8 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Med9 PF07544.13 EFE40874.1 - 0.022 14.8 3.6 0.028 14.5 3.2 1.3 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Nup54 PF13874.6 EFE40874.1 - 0.029 14.5 0.5 0.035 14.2 0.5 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 COG6 PF06419.11 EFE40874.1 - 0.071 11.3 0.8 0.081 11.1 0.8 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 V_ATPase_I PF01496.19 EFE40874.1 - 0.072 11.0 0.9 0.073 11.0 0.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FapA PF03961.13 EFE40874.1 - 0.085 11.5 0.2 0.093 11.3 0.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A UPF0242 PF06785.11 EFE40874.1 - 0.12 12.4 2.3 0.14 12.3 2.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus MMPL PF03176.15 EFE40874.1 - 0.25 10.2 0.1 0.27 10.1 0.1 1.0 1 0 0 1 1 1 0 MMPL family DivIC PF04977.15 EFE40874.1 - 0.34 10.7 3.4 0.54 10.1 3.4 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF4140 PF13600.6 EFE40874.1 - 0.39 11.2 2.3 0.79 10.2 2.3 1.5 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) XhlA PF10779.9 EFE40874.1 - 3.3 8.0 4.8 5.2 7.3 4.8 1.2 1 0 0 1 1 1 0 Haemolysin XhlA HECT PF00632.25 EFE40876.1 - 1.7e-90 303.7 0.1 1e-82 278.1 0.0 2.1 1 1 1 2 2 2 2 HECT-domain (ubiquitin-transferase) WW PF00397.26 EFE40876.1 - 4.1e-33 113.1 31.6 9.2e-13 48.0 5.7 4.7 5 0 0 5 5 5 3 WW domain Aminotran_5 PF00266.19 EFE40878.1 - 1.6e-28 99.7 0.0 2.3e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFE40878.1 - 0.017 14.3 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II NIF PF03031.18 EFE40879.1 - 2.6e-54 183.2 0.0 3.9e-54 182.7 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SlyX PF04102.12 EFE40880.1 - 0.05 14.2 1.0 5.2 7.8 0.5 2.3 2 0 0 2 2 2 0 SlyX Spc7 PF08317.11 EFE40880.1 - 0.068 12.0 0.4 0.08 11.8 0.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein ATG16 PF08614.11 EFE40880.1 - 0.73 10.0 6.8 0.056 13.7 0.8 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Rhomboid PF01694.22 EFE40881.1 - 2.5e-13 50.3 12.7 1.2e-12 48.0 10.6 2.6 2 1 0 2 2 2 1 Rhomboid family PhoD PF09423.10 EFE40882.1 - 1.8e-07 30.5 0.3 0.0006 18.9 0.1 2.7 2 1 0 2 2 2 2 PhoD-like phosphatase DUF3220 PF11516.8 EFE40882.1 - 0.11 12.8 0.0 0.33 11.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3120) Gryzun PF07919.12 EFE40884.1 - 9.3e-213 708.3 0.0 1e-212 708.1 0.0 1.0 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Gryzun-like PF12742.7 EFE40884.1 - 0.0028 17.6 0.0 0.0089 16.0 0.0 1.9 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking Foie-gras_1 PF11817.8 EFE40885.1 - 6.6e-86 288.1 4.0 5.7e-76 255.5 3.4 2.3 2 0 0 2 2 2 2 Foie gras liver health family 1 MelC1 PF06236.11 EFE40886.1 - 0.03 14.4 2.9 0.037 14.1 2.9 1.2 1 0 0 1 1 1 0 Tyrosinase co-factor MelC1 PARM PF17061.5 EFE40886.1 - 0.088 12.9 8.3 0.1 12.7 8.3 1.0 1 0 0 1 1 1 0 PARM GTSE1_N PF15259.6 EFE40886.1 - 0.096 12.9 3.0 0.12 12.5 3.0 1.1 1 0 0 1 1 1 0 G-2 and S-phase expressed 1 DUF3446 PF11928.8 EFE40886.1 - 0.2 12.0 17.5 0.58 10.5 17.5 1.8 1 1 0 1 1 1 0 Early growth response N-terminal domain ORC6 PF05460.13 EFE40886.1 - 0.35 10.1 6.9 0.4 9.9 6.9 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Peptidase_S64 PF08192.11 EFE40886.1 - 2.7 6.4 5.4 3.2 6.1 5.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 FAM199X PF15814.5 EFE40886.1 - 9.2 5.2 11.4 12 4.9 11.4 1.1 1 0 0 1 1 1 0 Protein family FAM199X Macoilin PF09726.9 EFE40886.1 - 9.9 4.6 9.8 13 4.2 9.8 1.0 1 0 0 1 1 1 0 Macoilin family Abhydrolase_1 PF00561.20 EFE40887.1 - 4.5e-08 33.1 0.0 1.1e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE40887.1 - 0.00017 20.9 0.0 0.00099 18.4 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ribosomal_L6 PF00347.23 EFE40888.1 - 5.4e-17 62.2 10.5 1e-10 42.1 1.3 3.9 3 1 0 3 3 3 2 Ribosomal protein L6 Glutaredoxin PF00462.24 EFE40888.1 - 6.5e-12 45.5 0.0 1.6e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 Glutaredoxin RXT2_N PF08595.11 EFE40889.1 - 6.2e-24 84.8 1.0 3.6e-14 53.1 0.1 3.9 4 0 0 4 4 4 2 RXT2-like, N-terminal PEMT PF04191.13 EFE40890.1 - 1.2e-28 99.6 6.9 1.1e-27 96.5 3.4 2.4 1 1 1 2 2 2 2 Phospholipid methyltransferase UAA PF08449.11 EFE40890.1 - 0.21 10.7 3.8 0.49 9.5 3.8 1.6 1 1 0 1 1 1 0 UAA transporter family DUF924 PF06041.11 EFE40891.1 - 3.6e-49 167.4 0.1 4e-49 167.2 0.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) SUR7 PF06687.12 EFE40892.1 - 4.4e-34 118.0 8.4 4.4e-34 118.0 8.4 1.3 1 1 0 1 1 1 1 SUR7/PalI family Acetyltransf_1 PF00583.25 EFE40894.1 - 1.4e-11 44.6 0.0 2e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE40894.1 - 3.6e-08 33.4 0.0 4.8e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE40894.1 - 4.4e-07 29.8 0.0 7.6e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EFE40894.1 - 1.8e-05 25.1 0.0 3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE40894.1 - 0.0033 17.5 0.1 0.0055 16.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Macoilin PF09726.9 EFE40895.1 - 0.16 10.5 33.4 0.26 9.8 33.4 1.4 1 1 0 1 1 1 0 Macoilin family Golgin_A5 PF09787.9 EFE40895.1 - 3.6 6.9 32.9 0.38 10.2 13.6 3.0 3 0 0 3 3 3 0 Golgin subfamily A member 5 HEAT PF02985.22 EFE40896.1 - 1e-06 28.4 3.1 0.12 12.7 0.0 4.8 5 0 0 5 5 5 3 HEAT repeat Cnd1 PF12717.7 EFE40896.1 - 5.5e-06 26.5 0.0 3e-05 24.1 0.0 1.9 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EFE40896.1 - 0.0002 21.8 0.1 3.3 8.3 0.0 4.0 4 1 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.6 EFE40896.1 - 0.0035 17.7 0.2 0.15 12.5 0.1 3.1 1 1 2 3 3 3 2 HEAT repeats CoA_trans PF01144.23 EFE40896.1 - 0.11 11.8 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase Adaptin_N PF01602.20 EFE40896.1 - 0.14 10.7 0.0 1.1 7.7 0.0 1.9 1 1 2 3 3 3 0 Adaptin N terminal region Pkinase PF00069.25 EFE40896.1 - 0.26 10.6 0.0 1.1 8.6 0.0 1.8 1 1 0 1 1 1 0 Protein kinase domain LsmAD PF06741.13 EFE40898.1 - 4.6e-27 94.4 6.0 4.6e-27 94.4 6.0 2.1 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.6 EFE40898.1 - 1.4e-14 53.9 0.3 5.1e-14 52.2 0.0 2.1 2 0 0 2 2 2 1 Ataxin 2 SM domain MHC_I_C PF06623.11 EFE40898.1 - 2.8 7.9 5.9 3.8 7.5 0.0 3.5 3 0 0 3 3 3 0 MHC_I C-terminus AIP3 PF03915.13 EFE40899.1 - 4.8e-153 510.1 4.3 4.8e-153 510.1 4.3 1.5 2 0 0 2 2 2 1 Actin interacting protein 3 MIP-T3_C PF17749.1 EFE40899.1 - 0.0017 18.3 4.1 0.014 15.4 0.6 3.5 3 0 0 3 3 3 1 Microtubule-binding protein MIP-T3 C-terminal region Lectin_N PF03954.14 EFE40899.1 - 0.073 12.8 2.1 0.17 11.6 0.1 2.6 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Syntaxin_2 PF14523.6 EFE40899.1 - 0.31 11.4 6.4 1.8 9.0 0.1 3.9 3 1 1 4 4 4 0 Syntaxin-like protein RasGAP_C PF03836.15 EFE40899.1 - 1.8 8.7 10.3 0.47 10.6 0.3 4.1 5 0 0 5 5 5 0 RasGAP C-terminus ACOX PF01756.19 EFE40901.1 - 1.2e-45 155.2 0.0 2.3e-45 154.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 EFE40901.1 - 6.9e-30 104.2 0.7 1.4e-29 103.2 0.7 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 EFE40901.1 - 1.3e-11 44.5 0.0 4.3e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFE40901.1 - 1.1e-06 28.9 0.1 0.0015 18.8 0.0 2.4 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain ESSS PF10183.9 EFE40902.1 - 7.9e-05 22.8 0.1 9.2e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) RNB PF00773.19 EFE40903.1 - 1.9e-97 326.5 0.1 3.6e-97 325.6 0.1 1.5 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 EFE40903.1 - 4.7e-28 97.8 0.1 1.5e-27 96.1 0.1 1.9 1 1 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EFE40903.1 - 1.3e-26 92.4 1.2 3.3e-26 91.1 1.2 1.7 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 EFE40903.1 - 3.4e-21 75.1 0.0 9.5e-21 73.6 0.0 1.9 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 EFE40903.1 - 1.4e-12 48.1 0.4 5.9e-12 46.0 0.1 2.2 2 0 0 2 2 2 1 PIN domain CSD2 PF17876.1 EFE40903.1 - 2.3e-10 40.5 0.1 1.7e-06 28.1 0.0 3.1 2 0 0 2 2 2 2 Cold shock domain MFS_1 PF07690.16 EFE40904.1 - 6.5e-20 71.3 48.1 4.4e-11 42.3 17.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LIM PF00412.22 EFE40905.1 - 2.9e-27 94.7 18.1 1.9e-10 40.8 2.8 3.9 3 1 0 3 3 3 3 LIM domain Zn_ribbon_recom PF13408.6 EFE40905.1 - 0.0081 16.7 0.1 0.0081 16.7 0.1 2.6 4 0 0 4 4 4 1 Recombinase zinc beta ribbon domain DZR PF12773.7 EFE40905.1 - 1.1 9.4 24.7 85 3.3 4.7 4.4 2 1 1 3 3 3 0 Double zinc ribbon Methyltransf_4 PF02390.17 EFE40906.1 - 1.3e-46 158.2 0.1 2e-45 154.3 0.1 2.5 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 EFE40906.1 - 0.00075 20.2 0.0 0.0039 17.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE40906.1 - 0.0031 17.3 0.0 0.006 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFE40906.1 - 0.0033 17.0 0.0 0.077 12.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EFE40906.1 - 0.004 17.9 0.0 0.013 16.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE40906.1 - 0.035 14.7 0.0 1.4 9.6 0.0 3.0 4 0 0 4 4 4 0 Methyltransferase domain ESCRT-II PF05871.12 EFE40907.1 - 5.8e-52 175.7 1.2 6.9e-52 175.4 0.5 1.4 2 0 0 2 2 2 1 ESCRT-II complex subunit RTT107_BRCT_5 PF16770.5 EFE40908.1 - 1.5e-33 114.7 0.0 3.5e-31 107.0 0.0 3.4 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 EFE40908.1 - 3.2e-30 103.9 2.2 2e-17 62.9 0.3 5.7 5 1 0 5 5 5 3 twin BRCT domain BRCT PF00533.26 EFE40908.1 - 1.6e-29 102.1 0.0 1.9e-08 34.5 0.0 6.8 6 1 0 6 6 6 6 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFE40908.1 - 4.5e-26 91.1 0.0 7.5e-05 23.1 0.0 6.4 6 0 0 6 6 6 5 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EFE40908.1 - 0.00023 21.4 0.1 7.7 6.9 0.0 4.4 4 0 0 4 4 4 1 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EFE40908.1 - 0.036 14.1 0.7 6 7.0 0.0 3.1 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain RTA1 PF04479.13 EFE40910.1 - 6.6e-24 84.7 0.2 9.2e-24 84.2 0.2 1.2 1 0 0 1 1 1 1 RTA1 like protein HAD PF12710.7 EFE40912.1 - 1.1e-15 58.6 0.0 1.3e-15 58.3 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EFE40912.1 - 0.00055 19.5 0.0 0.00066 19.3 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HECT PF00632.25 EFE40913.1 - 3e-74 250.3 0.0 2.2e-73 247.4 0.0 2.0 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Adaptin_N PF01602.20 EFE40913.1 - 0.0082 14.8 0.1 0.0082 14.8 0.1 2.4 3 0 0 3 3 3 1 Adaptin N terminal region HEAT PF02985.22 EFE40913.1 - 0.013 15.7 1.2 4 8.0 0.1 4.1 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 EFE40913.1 - 0.061 13.8 0.0 0.52 10.9 0.0 2.6 2 0 0 2 2 2 0 HEAT-like repeat Arm PF00514.23 EFE40913.1 - 0.19 11.8 11.1 32 4.8 0.1 6.6 7 1 1 8 8 8 0 Armadillo/beta-catenin-like repeat DUF5320 PF17253.2 EFE40914.1 - 0.36 11.9 15.1 2 9.5 0.2 3.5 3 1 0 3 3 3 0 Family of unknown function (DUF5320) F-box-like PF12937.7 EFE40915.1 - 0.0012 18.7 0.0 0.0027 17.6 0.0 1.6 1 0 0 1 1 1 1 F-box-like DUF3829 PF12889.7 EFE40915.1 - 0.14 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) COesterase PF00135.28 EFE40917.1 - 1.5e-76 258.3 0.0 1.8e-76 258.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE40917.1 - 1.5e-06 28.2 0.6 8.3e-06 25.8 0.6 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold F-actin_cap_A PF01267.17 EFE40918.1 - 1.1e-58 198.8 0.0 1.2e-58 198.6 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Dehydrin PF00257.19 EFE40920.1 - 0.039 14.5 1.8 0.11 13.0 1.8 1.7 1 0 0 1 1 1 0 Dehydrin SUIM_assoc PF16619.5 EFE40920.1 - 2.3 8.3 12.9 0.3 11.2 6.6 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 K_channel_TID PF07941.11 EFE40920.1 - 6.6 7.3 20.0 0.22 12.0 13.5 1.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain PAP2 PF01569.21 EFE40921.1 - 1.5e-17 63.6 0.8 1.5e-17 63.6 0.8 3.1 2 1 1 3 3 3 2 PAP2 superfamily Med7 PF05983.11 EFE40922.1 - 6.9e-52 176.3 0.5 6.9e-52 176.3 0.5 2.2 3 0 0 3 3 3 1 MED7 protein RRN3 PF05327.11 EFE40922.1 - 0.01 14.4 2.0 0.015 13.8 2.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NDUFA12 PF05071.16 EFE40922.1 - 1.1 10.2 3.6 0.51 11.2 0.8 1.9 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 HEAT_EZ PF13513.6 EFE40923.1 - 2.8e-19 69.2 1.9 1.3e-05 25.6 0.0 9.3 9 2 1 10 10 10 3 HEAT-like repeat HEAT PF02985.22 EFE40923.1 - 2.8e-18 64.4 4.3 0.00053 20.0 0.1 9.1 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 EFE40923.1 - 1e-16 61.1 2.3 0.00042 20.6 0.0 6.8 6 1 1 7 7 7 4 HEAT repeats IFRD PF05004.13 EFE40923.1 - 4.8e-10 39.0 1.4 0.00062 19.0 0.1 4.4 2 1 3 5 5 5 2 Interferon-related developmental regulator (IFRD) Cnd1 PF12717.7 EFE40923.1 - 1.5e-06 28.3 0.5 1.6 8.8 0.0 4.8 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFE40923.1 - 1.8e-06 28.4 0.0 2 9.1 0.0 6.0 6 1 0 6 6 6 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EFE40923.1 - 4.8e-06 26.0 0.3 4.7e-05 22.7 0.0 2.7 3 0 0 3 3 3 1 RNAPII transcription regulator C-terminal IBN_N PF03810.19 EFE40923.1 - 3.8e-05 23.5 1.5 0.00014 21.7 0.2 2.7 3 0 0 3 3 3 1 Importin-beta N-terminal domain ParcG PF10274.9 EFE40923.1 - 0.00053 20.1 0.0 0.025 14.7 0.1 2.8 2 0 0 2 2 2 1 Parkin co-regulated protein CLASP_N PF12348.8 EFE40923.1 - 0.001 18.7 0.2 0.13 11.8 0.0 3.7 5 0 0 5 5 5 1 CLASP N terminal RTP1_C1 PF10363.9 EFE40923.1 - 0.016 15.4 0.5 2.8 8.2 0.0 3.9 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 UNC45-central PF11701.8 EFE40923.1 - 0.018 15.0 0.1 0.094 12.7 0.1 2.4 1 1 0 1 1 1 0 Myosin-binding striated muscle assembly central RIX1 PF08167.12 EFE40923.1 - 0.019 14.7 0.0 0.31 10.7 0.0 3.0 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Tti2 PF10521.9 EFE40923.1 - 0.023 14.2 0.1 3 7.3 0.0 3.4 3 1 1 4 4 4 0 Tti2 family Ecm29 PF13001.7 EFE40923.1 - 0.025 13.3 0.2 0.32 9.6 0.0 2.6 1 1 0 2 2 2 0 Proteasome stabiliser Adaptin_N PF01602.20 EFE40923.1 - 0.034 12.7 0.4 9.7 4.6 0.0 3.1 3 1 0 3 3 3 0 Adaptin N terminal region NPC1_N PF16414.5 EFE40924.1 - 1.8e-82 276.6 8.0 2.7e-82 276.0 8.0 1.3 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 EFE40924.1 - 4.2e-73 246.8 9.9 2.6e-72 244.2 10.0 1.9 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 EFE40924.1 - 1.1e-52 177.9 5.8 1.1e-52 177.9 5.8 3.2 3 1 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EFE40924.1 - 3.6e-07 29.4 8.0 3.6e-07 29.4 8.0 3.8 4 1 0 4 4 4 1 MMPL family Folate_rec PF03024.14 EFE40924.1 - 0.00015 21.7 2.7 0.00035 20.5 2.7 1.6 1 0 0 1 1 1 1 Folate receptor family DUF2433 PF10360.9 EFE40926.1 - 1.1e-48 164.4 0.0 2e-48 163.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) TFIIA PF03153.13 EFE40926.1 - 0.17 11.8 13.0 0.28 11.1 13.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAP1 PF08601.10 EFE40927.1 - 2.9e-93 313.5 35.3 8.5e-90 302.2 26.5 4.2 1 1 1 2 2 2 1 Transcription factor PAP1 bZIP_1 PF00170.21 EFE40927.1 - 5.3e-08 32.8 9.1 1.1e-07 31.8 9.1 1.5 1 0 0 1 1 1 1 bZIP transcription factor SlyX PF04102.12 EFE40927.1 - 0.00067 20.2 0.3 0.0015 19.1 0.3 1.6 1 0 0 1 1 1 1 SlyX DUF16 PF01519.16 EFE40927.1 - 0.0095 16.4 1.4 0.017 15.6 1.4 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF16 SHE3 PF17078.5 EFE40927.1 - 0.12 12.1 3.1 0.2 11.4 3.1 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 COG7 PF10191.9 EFE40927.1 - 0.12 10.5 0.1 0.18 10.0 0.1 1.1 1 0 0 1 1 1 0 Golgi complex component 7 (COG7) bZIP_Maf PF03131.17 EFE40927.1 - 0.17 12.4 10.1 0.46 11.0 10.1 1.7 1 0 0 1 1 1 0 bZIP Maf transcription factor TSC22 PF01166.18 EFE40927.1 - 0.29 11.5 0.9 0.61 10.4 0.9 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family Tudor_3 PF18115.1 EFE40928.1 - 2.3e-07 30.5 0.0 3.8e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 EFE40928.1 - 0.0051 16.8 0.0 0.0081 16.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) DUF1325 PF07039.11 EFE40928.1 - 0.13 12.4 0.5 0.53 10.4 0.0 2.1 2 0 0 2 2 2 0 SGF29 tudor-like domain Tudor_2 PF18104.1 EFE40928.1 - 0.18 11.5 0.0 0.42 10.3 0.0 1.7 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain TRAUB PF08164.12 EFE40929.1 - 1.4e-30 105.6 1.2 4.3e-30 104.1 0.0 2.5 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 EFE40929.1 - 5.8e-26 91.8 1.6 5.8e-26 91.8 1.6 3.0 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor ParA PF10609.9 EFE40930.1 - 5.3e-52 176.7 0.0 6.3e-51 173.2 0.0 1.9 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase DUF2614 PF11023.8 EFE40930.1 - 0.13 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain Abhydrolase_3 PF07859.13 EFE40931.1 - 2.7e-25 89.5 0.5 1.2e-15 58.0 0.1 3.2 2 1 1 3 3 3 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFE40931.1 - 2.7e-14 52.8 0.0 9e-12 44.5 0.0 2.4 1 1 1 2 2 2 2 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 EFE40931.1 - 0.12 11.6 0.0 0.29 10.4 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 WGG PF10273.9 EFE40932.1 - 6.7e-29 100.4 0.1 1.2e-28 99.6 0.1 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 EFE40932.1 - 0.054 13.6 0.2 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain CDC45 PF02724.14 EFE40932.1 - 1.1 7.4 7.7 1.3 7.3 7.7 1.0 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EFE40932.1 - 1.1 8.5 5.5 1.5 8.1 5.5 1.1 1 0 0 1 1 1 0 NOA36 protein Tht1 PF04163.12 EFE40933.1 - 8.5e-07 28.1 12.0 1.5e-05 24.0 12.0 2.7 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Spore_IV_A PF09547.10 EFE40933.1 - 0.016 14.2 0.7 0.024 13.6 0.7 1.3 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) Ssu72 PF04722.13 EFE40933.1 - 0.024 14.2 0.0 0.061 12.9 0.0 1.6 1 0 0 1 1 1 0 Ssu72-like protein RPM2 PF08579.11 EFE40933.1 - 0.33 11.3 2.9 0.5 10.8 1.2 2.2 1 1 1 2 2 2 0 Mitochondrial ribonuclease P subunit (RPM2) Syntaxin_2 PF14523.6 EFE40933.1 - 4.7 7.7 12.7 3.8 7.9 3.6 3.1 2 1 1 3 3 3 0 Syntaxin-like protein Ribosomal_L6 PF00347.23 EFE40934.1 - 5.7e-18 65.4 0.0 8.2e-10 39.2 0.0 2.5 2 1 0 2 2 2 2 Ribosomal protein L6 Inositol_P PF00459.25 EFE40935.1 - 6.2e-52 176.8 0.4 1.5e-51 175.5 0.4 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family VHS PF00790.19 EFE40936.1 - 8.3e-20 71.1 0.0 1.1e-13 51.2 0.0 2.4 2 0 0 2 2 2 2 VHS domain ENTH PF01417.20 EFE40936.1 - 0.0019 18.2 0.1 0.0084 16.2 0.0 2.1 2 1 0 2 2 2 1 ENTH domain Bys1 PF04681.12 EFE40936.1 - 0.018 15.0 0.9 0.03 14.2 0.9 1.3 1 0 0 1 1 1 0 Blastomyces yeast-phase-specific protein Swm2 PF17083.5 EFE40936.1 - 0.055 13.5 0.3 0.32 11.0 0.0 2.3 2 1 0 2 2 2 0 Nucleolar protein Swm2 RunxI PF08504.11 EFE40936.1 - 0.86 10.4 4.2 1.7 9.4 2.5 2.0 2 0 0 2 2 2 0 Runx inhibition domain adh_short_C2 PF13561.6 EFE40937.1 - 1.2e-42 146.1 0.6 3.5e-41 141.3 0.6 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE40937.1 - 1.8e-38 132.0 0.1 4.4e-38 130.7 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE40937.1 - 4.1e-09 36.6 2.3 1.4e-07 31.6 0.1 2.2 2 0 0 2 2 2 1 KR domain ADH_zinc_N PF00107.26 EFE40937.1 - 0.00034 20.6 0.1 0.00059 19.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox PF00070.27 EFE40937.1 - 0.0026 18.3 1.6 0.054 14.1 0.4 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase PrpR_N PF06506.11 EFE40937.1 - 0.039 13.5 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 Propionate catabolism activator DUF1776 PF08643.10 EFE40937.1 - 0.058 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EFE40937.1 - 0.081 12.3 0.1 0.49 9.7 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DUF4536 PF15055.6 EFE40937.1 - 0.3 11.4 1.5 8.5 6.7 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) CP2 PF04516.15 EFE40938.1 - 1.3e-67 227.4 0.0 1.9e-67 226.9 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor DEAD PF00270.29 EFE40939.1 - 2.2e-44 151.3 0.1 4.6e-44 150.3 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE40939.1 - 7e-27 94.0 0.0 4.5e-26 91.4 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE40939.1 - 8.2e-07 29.2 0.0 3.7e-06 27.0 0.0 2.0 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EFE40939.1 - 4.6e-05 22.4 0.0 0.061 12.1 0.0 2.5 2 1 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 EFE40939.1 - 0.0054 17.0 0.2 0.038 14.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain Ank_2 PF12796.7 EFE40940.1 - 7.1e-14 52.2 0.0 4.7e-10 39.9 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE40940.1 - 2.8e-13 50.1 0.0 0.00011 22.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFE40940.1 - 2.3e-09 37.3 0.0 0.0074 16.7 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EFE40940.1 - 3e-09 36.4 0.0 0.15 12.7 0.0 4.9 4 1 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFE40940.1 - 7.2e-08 32.6 0.0 0.075 13.4 0.0 3.7 2 1 2 4 4 4 2 Ankyrin repeats (many copies) DUF3734 PF12536.8 EFE40940.1 - 0.014 15.7 0.0 0.53 10.7 0.0 2.1 2 0 0 2 2 2 0 Patatin phospholipase TPR_21 PF09976.9 EFE40940.1 - 0.043 13.5 0.0 0.076 12.7 0.0 1.4 1 1 0 1 1 1 0 Tetratricopeptide repeat-like domain VWA_3_C PF18571.1 EFE40940.1 - 0.11 12.3 2.3 2.6 8.0 0.1 2.9 3 0 0 3 3 3 0 von Willebrand factor type A C-terminal domain FtsJ PF01728.19 EFE40941.1 - 5e-64 215.7 0.0 6.2e-64 215.3 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase FAD_binding_1 PF00667.20 EFE40942.1 - 5.1e-53 179.9 0.0 7.1e-53 179.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EFE40942.1 - 3.4e-09 37.3 0.0 1.1e-08 35.7 0.0 1.9 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF5435 PF17503.2 EFE40942.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5435) MAT1 PF06391.13 EFE40944.1 - 4.9e-42 144.1 17.6 6.5e-42 143.7 17.6 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EFE40944.1 - 1.9e-32 110.9 8.5 3e-32 110.3 8.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE40944.1 - 0.00014 21.7 5.1 0.00024 20.9 5.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE40944.1 - 0.00016 21.5 3.7 0.00041 20.1 3.7 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFE40944.1 - 0.0014 18.4 4.1 0.0029 17.4 4.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFE40944.1 - 0.0019 18.5 6.2 0.0033 17.7 6.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.6 EFE40944.1 - 0.012 15.4 5.1 0.069 13.0 1.9 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 EFE40944.1 - 0.017 14.7 1.4 0.034 13.8 1.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EFE40944.1 - 0.03 14.3 7.2 0.23 11.4 7.7 2.0 1 1 1 2 2 2 0 zinc-RING finger domain DUF3797 PF12677.7 EFE40944.1 - 0.07 13.0 2.3 0.16 11.9 2.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) zf-RING_UBOX PF13445.6 EFE40944.1 - 0.39 10.8 6.8 0.78 9.8 6.8 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 EFE40944.1 - 1.8 8.5 8.0 41 4.2 8.8 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 TMF_TATA_bd PF12325.8 EFE40945.1 - 0.058 13.6 0.7 0.15 12.3 0.7 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding ZapB PF06005.12 EFE40945.1 - 0.14 12.6 1.8 0.31 11.5 1.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB APG6_N PF17675.1 EFE40945.1 - 0.16 12.5 0.8 0.36 11.3 0.8 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Cep57_CLD PF14073.6 EFE40945.1 - 2.8 7.9 6.3 0.23 11.5 1.1 1.8 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 adh_short PF00106.25 EFE40946.1 - 4.2e-24 85.1 0.0 6e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE40946.1 - 1.1e-13 51.4 0.0 1.6e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE40946.1 - 0.0013 18.7 0.1 0.0034 17.3 0.0 1.7 2 0 0 2 2 2 1 KR domain DUF1263 PF06882.12 EFE40946.1 - 0.091 12.8 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1263) NAD_binding_10 PF13460.6 EFE40946.1 - 0.11 12.3 0.0 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 NAD(P)H-binding F-box-like PF12937.7 EFE40948.1 - 1e-05 25.3 0.1 2.2e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like HisKA_3 PF07730.13 EFE40948.1 - 0.078 13.5 0.0 0.18 12.4 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase NHR2 PF08788.11 EFE40948.1 - 0.11 12.3 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 NHR2 domain like Glyco_hydro_18 PF00704.28 EFE40949.1 - 4.4e-67 227.0 0.3 7.5e-67 226.3 0.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EFE40949.1 - 1.8e-12 47.5 15.3 1.8e-12 47.5 15.3 4.2 6 0 0 6 6 6 2 Chitin recognition protein PEX11 PF05648.14 EFE40951.1 - 6.9e-26 91.1 0.0 8.4e-26 90.8 0.0 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) FMN_red PF03358.15 EFE40952.1 - 1.1e-08 34.9 0.0 1.6e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EFE40952.1 - 6.3e-07 29.3 0.0 8.2e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 EFE40952.1 - 0.011 16.0 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 Flavodoxin domain DcrB PF08786.11 EFE40953.1 - 0.24 11.5 0.0 0.3 11.2 0.0 1.1 1 0 0 1 1 1 0 DcrB NPL4 PF05021.15 EFE40954.1 - 2.2e-139 464.1 0.0 2.7e-139 463.8 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EFE40954.1 - 8e-69 230.4 0.1 1.3e-68 229.7 0.1 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region Kinesin PF00225.23 EFE40955.1 - 1.2e-116 389.3 0.1 2e-116 388.6 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFE40955.1 - 1.3e-26 93.3 1.4 2e-26 92.7 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding Herpes_UL14 PF03580.14 EFE40955.1 - 0.0039 17.4 1.5 0.013 15.7 1.5 1.9 1 0 0 1 1 1 1 Herpesvirus UL14-like protein ArgoL2 PF16488.5 EFE40955.1 - 0.12 12.7 0.3 0.33 11.3 0.3 1.8 1 0 0 1 1 1 0 Argonaute linker 2 domain ING PF12998.7 EFE40955.1 - 3.8 8.2 7.7 3.6 8.2 2.2 3.1 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF5565 PF17720.1 EFE40956.1 - 0.079 11.8 0.0 0.096 11.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5565) Tim17 PF02466.19 EFE40957.1 - 0.00029 21.2 3.6 0.00042 20.7 2.9 1.6 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family DUF1324 PF07038.11 EFE40957.1 - 0.028 14.7 0.0 0.069 13.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1324) cNMPbd_u2 PF16643.5 EFE40959.1 - 8.8e-38 130.2 9.1 8.8e-38 130.2 9.1 1.9 2 0 0 2 2 2 1 Unstructured region on cNMP-binding protein cNMP_binding PF00027.29 EFE40959.1 - 8.5e-35 118.7 0.0 5.6e-21 74.4 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_6 PF13516.6 EFE40959.1 - 2.2e-11 42.9 3.7 1.5 9.0 0.0 7.9 9 0 0 9 9 9 4 Leucine Rich repeat F-box-like PF12937.7 EFE40959.1 - 2.9e-06 27.1 1.6 6.9e-06 25.9 0.5 2.3 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 EFE40959.1 - 1.5e-05 25.2 8.4 0.064 13.7 0.8 6.4 5 2 3 8 8 8 2 Leucine Rich repeats (2 copies) F-box PF00646.33 EFE40959.1 - 4.1e-05 23.4 1.2 4.1e-05 23.4 1.2 3.5 3 0 0 3 3 3 1 F-box domain LRR_1 PF00560.33 EFE40959.1 - 0.013 15.9 11.5 60 4.8 0.1 7.7 9 1 1 10 10 10 0 Leucine Rich Repeat SAM_Ste50p PF09235.10 EFE40959.1 - 0.09 13.0 3.4 9.5 6.5 0.5 4.1 3 2 0 3 3 3 0 Ste50p, sterile alpha motif CDC45 PF02724.14 EFE40960.1 - 1.2 7.3 3.7 1.4 7.2 3.7 1.0 1 0 0 1 1 1 0 CDC45-like protein EVI2A PF05399.11 EFE40960.1 - 4.1 6.9 6.7 6.1 6.4 6.7 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Slx4 PF09494.10 EFE40962.1 - 8.3e-25 86.5 0.3 1.4e-24 85.8 0.3 1.4 1 0 0 1 1 1 1 Slx4 endonuclease Bax1-I PF01027.20 EFE40963.1 - 4.9e-31 108.2 11.5 4.9e-31 108.2 11.5 1.4 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 Spectrin PF00435.21 EFE40964.1 - 0.27 11.7 2.9 8.6 6.9 0.5 2.5 1 1 1 2 2 2 0 Spectrin repeat Cutinase PF01083.22 EFE40965.1 - 1.6e-36 125.9 0.0 2.3e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Cutinase Abhydrolase_2 PF02230.16 EFE40965.1 - 0.00081 19.3 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase PE-PPE PF08237.11 EFE40965.1 - 0.13 11.7 0.1 0.29 10.6 0.1 1.7 1 1 0 1 1 1 0 PE-PPE domain Abhydrolase_1 PF00561.20 EFE40965.1 - 0.15 11.7 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Glyco_hydro_76 PF03663.14 EFE40966.1 - 6.3e-24 85.2 0.2 7.3e-16 58.6 0.1 2.4 2 0 0 2 2 2 2 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFE40966.1 - 0.053 12.6 0.0 0.094 11.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 DUF2236 PF09995.9 EFE40967.1 - 2.2e-07 31.3 0.0 4.8e-07 30.2 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) FAM176 PF14851.6 EFE40968.1 - 0.54 9.9 4.8 7.7 6.2 2.3 2.6 2 1 1 3 3 3 0 FAM176 family TP2 PF01254.18 EFE40968.1 - 4.1 8.0 7.8 1.4 9.6 4.6 1.8 2 0 0 2 2 2 0 Nuclear transition protein 2 Acetate_kinase PF00871.17 EFE40969.1 - 4.1e-68 229.9 0.2 2.2e-45 155.0 0.1 2.0 2 0 0 2 2 2 2 Acetokinase family MCM6_C PF18263.1 EFE40969.1 - 0.043 14.1 0.1 0.093 13.0 0.1 1.5 1 0 0 1 1 1 0 MCM6 C-terminal winged-helix domain XFP_N PF09364.10 EFE40970.1 - 2.3e-147 490.6 0.0 3.3e-147 490.1 0.0 1.2 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 EFE40970.1 - 2.1e-76 255.9 0.0 3.2e-76 255.3 0.0 1.2 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 EFE40970.1 - 1.3e-74 249.8 0.0 1.9e-74 249.2 0.0 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase SH3_9 PF14604.6 EFE40970.1 - 0.21 11.5 0.3 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 Variant SH3 domain Ribosomal_S7e PF01251.18 EFE40971.1 - 4.1e-73 245.1 1.3 5.8e-64 215.2 0.8 2.0 2 0 0 2 2 2 2 Ribosomal protein S7e Vezatin PF12632.7 EFE40971.1 - 0.045 13.1 0.3 5.9 6.2 0.0 2.1 2 0 0 2 2 2 0 Mysoin-binding motif of peroxisomes EntA_Immun PF08951.10 EFE40971.1 - 0.053 13.9 0.1 0.12 12.8 0.1 1.5 1 0 0 1 1 1 0 Enterocin A Immunity Dynactin_p62 PF05502.13 EFE40972.1 - 4.1e-145 484.2 0.0 5e-145 484.0 0.0 1.0 1 0 0 1 1 1 1 Dynactin p62 family Methyltransf_11 PF08241.12 EFE40973.1 - 6.2e-08 33.2 0.0 1.3e-07 32.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE40973.1 - 2.2e-07 30.8 0.0 5.8e-07 29.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE40973.1 - 1.1e-05 26.0 0.0 3.6e-05 24.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE40973.1 - 0.0002 22.0 0.0 0.00042 21.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE40973.1 - 0.00051 19.9 0.0 0.0023 17.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE40973.1 - 0.028 13.8 0.0 0.046 13.0 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family GhoS PF11080.8 EFE40973.1 - 0.18 11.8 0.0 2.1 8.4 0.0 2.3 2 0 0 2 2 2 0 Endoribonuclease GhoS P16-Arc PF04699.14 EFE40974.1 - 7.8e-47 159.5 0.0 8.9e-47 159.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Cation_ATPase_C PF00689.21 EFE40975.1 - 2.1e-47 161.2 7.8 2.1e-47 161.2 7.8 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFE40975.1 - 1.6e-35 122.2 0.0 1.6e-35 122.2 0.0 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFE40975.1 - 8.7e-21 73.8 0.0 1.6e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFE40975.1 - 3.9e-16 60.0 1.1 1.5e-15 58.0 1.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFE40975.1 - 5.1e-09 35.7 0.2 3.6e-08 33.0 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFE40975.1 - 8.1e-05 22.5 0.0 0.0018 18.1 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ferlin_C PF16165.5 EFE40975.1 - 0.19 11.7 1.2 0.41 10.6 0.1 2.2 2 0 0 2 2 2 0 Ferlin C-terminus DUF1774 PF08611.10 EFE40975.1 - 0.7 10.3 8.3 0.29 11.5 0.2 3.2 3 0 0 3 3 3 0 Fungal protein of unknown function (DUF1774) 3Beta_HSD PF01073.19 EFE40978.1 - 2.3e-53 181.0 0.0 2.9e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFE40978.1 - 5.2e-30 104.7 0.0 6.7e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFE40978.1 - 3.9e-18 66.0 0.2 2.2e-15 56.9 0.1 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFE40978.1 - 1.3e-09 37.7 0.9 2.6e-08 33.4 0.0 2.1 1 1 1 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 EFE40978.1 - 4.2e-07 29.3 0.0 6.6e-07 28.7 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFE40978.1 - 1.4e-05 25.1 0.0 1.9e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EFE40978.1 - 1.6e-05 24.2 0.3 0.00011 21.5 0.2 2.3 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EFE40978.1 - 0.00012 22.1 0.7 0.0015 18.5 0.7 2.2 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EFE40978.1 - 0.0032 16.9 0.0 0.006 16.1 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 EFE40978.1 - 0.011 15.3 0.1 0.02 14.5 0.1 1.4 1 0 0 1 1 1 0 NmrA-like family TrkA_N PF02254.18 EFE40978.1 - 0.034 14.4 0.2 0.076 13.3 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain PglD_N PF17836.1 EFE40978.1 - 0.037 14.7 1.1 0.099 13.3 0.7 1.9 2 0 0 2 2 2 0 PglD N-terminal domain Sacchrp_dh_NADP PF03435.18 EFE40978.1 - 0.16 12.2 0.2 0.29 11.4 0.2 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Transket_pyr PF02779.24 EFE40979.1 - 1.7e-42 145.1 0.0 2.6e-42 144.5 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFE40979.1 - 1.3e-31 109.0 0.1 3.4e-31 107.7 0.0 1.7 2 0 0 2 2 2 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EFE40979.1 - 0.0078 16.5 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II DUF4200 PF13863.6 EFE40980.1 - 0.011 16.2 26.0 0.011 16.2 26.0 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF4200) Filament PF00038.21 EFE40980.1 - 6.5 6.2 60.4 0.051 13.2 39.8 2.1 2 0 0 2 2 2 0 Intermediate filament protein DUF21 PF01595.20 EFE40981.1 - 4.7e-27 94.8 0.0 7.3e-27 94.2 0.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EFE40981.1 - 0.0024 18.3 0.2 0.53 10.8 0.0 2.9 2 0 0 2 2 2 2 CBS domain His_Phos_1 PF00300.22 EFE40982.1 - 1.9e-15 57.1 0.1 4.4e-15 55.9 0.1 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF1799 PF08809.11 EFE40982.1 - 0.089 13.0 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Phage related hypothetical protein (DUF1799) HECT PF00632.25 EFE40983.1 - 1.2e-49 169.5 0.0 4.5e-49 167.6 0.0 1.9 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) zf-C2H2_2 PF12756.7 EFE40984.1 - 2.8e-35 120.7 20.7 1.3e-30 105.7 3.0 3.8 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EFE40984.1 - 7.1e-11 42.1 15.7 3.4e-05 24.0 2.7 4.6 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFE40984.1 - 1.3e-07 31.8 13.2 1.7e-05 25.0 3.0 3.9 3 0 0 3 3 3 2 Zinc-finger of C2H2 type Cytochrome-c551 PF10643.9 EFE40984.1 - 0.03 13.9 0.2 7.4 6.1 0.0 2.2 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 DUF2024 PF09630.10 EFE40984.1 - 0.036 13.9 5.0 0.079 12.8 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF2024) Cytochrome_CBB3 PF13442.6 EFE40984.1 - 0.053 13.8 3.1 11 6.4 0.1 3.1 2 0 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III zf-C2H2 PF00096.26 EFE40984.1 - 0.13 12.8 0.3 0.13 12.8 0.3 4.9 5 0 0 5 5 5 0 Zinc finger, C2H2 type Abhydrolase_3 PF07859.13 EFE40986.1 - 6.8e-06 26.1 0.0 1.6e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EFE40986.1 - 0.00087 19.0 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EFE40986.1 - 0.0018 17.8 0.0 0.0042 16.6 0.0 1.5 2 0 0 2 2 2 1 Prolyl oligopeptidase family Pkinase PF00069.25 EFE40987.1 - 1.1e-69 234.8 0.0 1.4e-69 234.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE40987.1 - 4.1e-31 108.2 0.0 5.3e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE40987.1 - 0.00016 21.1 0.0 0.00036 20.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFE40987.1 - 0.00058 18.9 0.0 0.013 14.5 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFE40987.1 - 0.0037 17.2 0.0 0.0071 16.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFE40987.1 - 0.028 13.5 0.0 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 2OG-FeII_Oxy_2 PF13532.6 EFE40988.1 - 1.6e-29 103.5 0.0 7.7e-29 101.3 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C2HC_2 PF13913.6 EFE40990.1 - 0.0014 18.5 0.0 0.003 17.4 0.0 1.5 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 EFE40990.1 - 0.007 17.1 0.3 0.017 15.9 0.3 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger JAKMIP_CC3 PF16034.5 EFE40990.1 - 0.012 15.6 4.1 0.029 14.3 4.1 1.6 1 0 0 1 1 1 0 JAKMIP CC3 domain zf-Di19 PF05605.12 EFE40990.1 - 0.013 15.7 0.1 0.028 14.7 0.1 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EFE40990.1 - 0.057 13.9 0.4 0.12 12.8 0.4 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type PRKG1_interact PF15898.5 EFE40990.1 - 7.5 7.5 9.1 1.2 10.0 0.1 3.0 4 0 0 4 4 4 0 cGMP-dependent protein kinase interacting domain MFS_1 PF07690.16 EFE40992.1 - 7.7e-39 133.6 41.5 7.7e-39 133.6 41.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE40992.1 - 6.4e-10 38.5 14.3 6.4e-10 38.5 14.3 2.9 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFE40992.1 - 0.0035 15.8 6.4 0.0035 15.8 6.4 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans PF04082.18 EFE40993.1 - 7.6e-14 51.4 0.0 1.2e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.26 EFE40994.1 - 4.6e-67 226.3 0.0 9.6e-67 225.2 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 EFE40994.1 - 7.1e-48 163.4 0.0 1.3e-47 162.5 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EFE40994.1 - 4.9e-46 156.9 0.0 9.8e-46 155.9 0.0 1.5 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 EFE40994.1 - 1.8e-40 139.4 0.5 1.2e-39 136.7 0.1 2.1 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFE40994.1 - 3.3e-28 98.1 0.1 3.3e-28 98.1 0.1 1.9 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EFE40994.1 - 1.5e-19 70.5 0.0 5e-19 68.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EFE40994.1 - 4.3e-15 56.1 0.0 1e-14 55.0 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 EFE40994.1 - 2.2e-14 53.9 0.0 8e-14 52.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE40994.1 - 3.2e-12 47.0 0.0 9.3e-12 45.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE40994.1 - 2.7e-10 40.3 0.0 6e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE40994.1 - 1.7e-09 37.6 0.0 5.7e-09 36.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFE40994.1 - 1.9e-07 30.7 0.0 4.3e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Ubie_methyltran PF01209.18 EFE40994.1 - 1.3e-05 24.7 0.0 2.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family adh_short_C2 PF13561.6 EFE40994.1 - 1.6e-05 24.6 0.0 3e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 EFE40994.1 - 3e-05 24.3 0.2 9.2e-05 22.7 0.2 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 EFE40994.1 - 0.00019 20.9 0.0 0.00047 19.6 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_16 PF10294.9 EFE40994.1 - 0.018 14.8 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_28 PF02636.17 EFE40994.1 - 0.033 13.8 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_24 PF13578.6 EFE40994.1 - 0.067 14.2 0.0 0.34 11.9 0.0 2.3 2 0 0 2 2 1 0 Methyltransferase domain NodS PF05401.11 EFE40994.1 - 0.11 12.2 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) AA_permease_2 PF13520.6 EFE40995.1 - 3.3e-56 190.9 48.8 4e-56 190.6 48.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE40995.1 - 5.4e-19 68.1 41.2 7.4e-19 67.7 41.2 1.1 1 0 0 1 1 1 1 Amino acid permease ABA_GPCR PF12430.8 EFE40995.1 - 5 6.9 10.0 18 5.0 10.0 1.9 1 1 0 1 1 1 0 Abscisic acid G-protein coupled receptor GSDH PF07995.11 EFE40996.1 - 0.015 14.6 0.1 0.017 14.5 0.1 1.3 1 0 0 1 1 1 0 Glucose / Sorbosone dehydrogenase DUF3237 PF11578.8 EFE40998.1 - 3.6e-07 30.1 0.1 5.3e-07 29.6 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3237) DLH PF01738.18 EFE40999.1 - 6e-14 52.1 0.0 7e-14 51.9 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Cu-oxidase_3 PF07732.15 EFE41000.1 - 5.1e-44 149.1 0.2 4.4e-43 146.1 0.2 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFE41000.1 - 6e-39 132.9 3.7 5.8e-36 123.3 0.1 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EFE41000.1 - 9.9e-33 113.5 0.3 3e-32 112.0 0.0 2.0 3 0 0 3 3 3 1 Multicopper oxidase Atx10homo_assoc PF09759.9 EFE41000.1 - 0.22 11.6 0.0 0.39 10.8 0.0 1.3 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain MFS_1 PF07690.16 EFE41002.1 - 5.1e-20 71.7 53.8 1.7e-10 40.4 11.1 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily FAD_binding_4 PF01565.23 EFE41003.1 - 6.1e-21 74.6 0.5 1e-20 73.9 0.5 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE41003.1 - 0.023 14.8 0.0 0.14 12.3 0.0 2.3 2 0 0 2 2 2 0 Berberine and berberine like Med8 PF10232.9 EFE41007.1 - 4.6e-60 203.1 0.6 5.6e-60 202.8 0.6 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 PQ-loop PF04193.14 EFE41008.1 - 6.9e-18 64.2 8.5 1.9e-12 46.7 1.6 3.3 4 0 0 4 4 4 2 PQ loop repeat UbiA PF01040.18 EFE41009.1 - 6.5e-56 189.4 17.7 6.5e-56 189.4 17.7 1.7 1 1 0 2 2 2 1 UbiA prenyltransferase family Fungal_trans_2 PF11951.8 EFE41010.1 - 0.0039 16.1 0.2 0.005 15.7 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box PF00646.33 EFE41011.1 - 0.3 11.0 0.1 0.3 11.0 0.1 3.1 3 0 0 3 3 3 0 F-box domain CTP_transf_like PF01467.26 EFE41012.1 - 0.11 12.6 2.6 1.3 9.2 0.2 2.4 2 1 0 2 2 2 0 Cytidylyltransferase-like WD40 PF00400.32 EFE41013.1 - 2.5e-14 53.4 4.2 5.1e-05 24.0 0.0 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat TFIIA PF03153.13 EFE41013.1 - 1.3 9.0 28.9 3.4 7.6 28.9 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit mRNA_triPase PF02940.15 EFE41014.1 - 1.2e-60 205.0 0.0 1.9e-60 204.3 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Kelch_3 PF13415.6 EFE41015.1 - 1.3e-16 60.5 8.9 3.7e-10 39.8 0.0 6.0 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.6 EFE41015.1 - 5e-14 52.0 0.5 0.00021 21.3 0.0 5.2 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFE41015.1 - 4.7e-13 48.9 0.6 0.071 13.4 0.0 5.7 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFE41015.1 - 3e-11 42.7 0.0 0.032 13.8 0.0 4.1 3 1 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 EFE41015.1 - 1.7e-09 37.5 0.8 0.0091 16.0 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 EFE41015.1 - 4.9e-05 23.1 9.9 0.0028 17.6 0.0 5.6 7 0 0 7 7 7 1 Kelch motif AhpC-TSA PF00578.21 EFE41016.1 - 4.8e-28 97.6 0.0 7.5e-28 96.9 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFE41016.1 - 1.3e-11 44.5 0.0 1.4e-10 41.1 0.0 2.2 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.9 EFE41016.1 - 5.1e-09 35.8 0.1 8.5e-09 35.1 0.1 1.3 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SR-25 PF10500.9 EFE41016.1 - 0.27 10.8 8.3 0.4 10.3 8.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein His_Phos_2 PF00328.22 EFE41017.1 - 1.3e-64 219.0 0.0 1.5e-64 218.8 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) bZIP_2 PF07716.15 EFE41018.1 - 2.2e-05 24.5 10.4 3.4e-05 23.8 10.4 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EFE41018.1 - 4.3 7.5 11.6 8.7 6.5 11.5 1.5 1 1 0 1 1 1 0 bZIP transcription factor APH PF01636.23 EFE41021.1 - 4.5e-13 49.7 0.3 1.7e-12 47.8 0.0 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE41021.1 - 0.0067 15.3 0.0 0.28 10.0 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) Amidoligase_2 PF12224.8 EFE41022.1 - 1.4e-13 51.1 0.0 3.8e-13 49.7 0.0 1.7 1 1 0 1 1 1 1 Putative amidoligase enzyme MFS_1 PF07690.16 EFE41023.1 - 9.7e-12 44.5 41.0 1e-11 44.4 39.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EFE41023.1 - 5.9e-08 32.6 7.2 5.9e-08 32.6 7.2 3.0 3 1 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sas10_Utp3 PF04000.15 EFE41024.1 - 8.8e-19 67.9 1.7 3.1e-18 66.2 1.7 2.0 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Glypican PF01153.19 EFE41024.1 - 0.4 9.5 2.6 0.66 8.7 2.6 1.3 1 0 0 1 1 1 0 Glypican DNA_pol_phi PF04931.13 EFE41024.1 - 5.5 5.0 20.7 2.4 6.1 17.0 1.9 2 0 0 2 2 2 0 DNA polymerase phi FMO-like PF00743.19 EFE41026.1 - 3.8e-15 55.3 0.0 8.4e-15 54.2 0.0 1.5 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFE41026.1 - 1e-13 51.2 0.0 4.5e-10 39.3 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFE41026.1 - 3.6e-12 46.1 0.0 1.9e-11 43.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE41026.1 - 1.7e-10 40.6 0.0 4.2e-08 32.7 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFE41026.1 - 5.5e-07 29.7 1.0 2.3e-05 24.6 0.0 3.0 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFE41026.1 - 2.3e-06 28.0 2.2 0.042 14.4 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EFE41026.1 - 5.4e-06 25.9 0.1 0.0052 16.1 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EFE41026.1 - 0.00038 20.5 1.5 0.07 13.1 0.0 3.3 4 0 0 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 EFE41026.1 - 0.0012 18.5 2.5 0.012 15.2 0.5 3.0 2 1 0 4 4 4 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EFE41026.1 - 0.0064 16.9 0.0 0.077 13.4 0.0 2.3 2 0 0 2 2 2 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 EFE41026.1 - 0.0068 16.3 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EFE41026.1 - 0.015 15.4 0.1 5.2 7.1 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EFE41026.1 - 0.028 13.5 0.2 0.028 13.5 0.2 1.5 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 EFE41026.1 - 0.13 11.0 1.0 1.2 7.8 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein FAD_oxidored PF12831.7 EFE41026.1 - 0.51 9.6 1.2 1.5 8.0 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 EFE41026.1 - 7.3 5.5 5.9 0.97 8.4 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A NmrA PF05368.13 EFE41027.1 - 4.6e-37 127.8 0.0 7.1e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFE41027.1 - 4.6e-13 49.5 0.0 6.4e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EFE41027.1 - 0.0049 17.3 0.1 0.0093 16.4 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 EFE41027.1 - 0.044 13.3 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Pkinase PF00069.25 EFE41028.1 - 3e-29 102.2 0.0 1.9e-28 99.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41028.1 - 4e-06 26.3 0.0 0.013 14.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFE41029.1 - 4.8e-10 39.8 0.0 1.6e-09 38.0 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE41029.1 - 0.0081 15.8 0.1 0.013 15.1 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fungal_trans PF04082.18 EFE41032.1 - 1.1e-12 47.6 0.0 2e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 EFE41033.1 - 0.0005 19.6 0.0 0.0052 16.3 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE41033.1 - 0.0032 17.0 0.0 0.0049 16.4 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Transferase PF02458.15 EFE41034.1 - 2.5e-09 36.3 0.0 1.4e-07 30.5 0.1 2.7 2 1 0 2 2 2 1 Transferase family MFS_1 PF07690.16 EFE41035.1 - 8.1e-32 110.5 49.6 8.1e-32 110.5 49.6 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE41035.1 - 1.8e-20 72.9 15.4 2.3e-20 72.6 15.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFE41035.1 - 1e-12 47.7 10.7 1e-12 47.7 10.7 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EFE41035.1 - 2.6 6.2 7.2 1.2 7.4 4.4 1.8 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family PhyH PF05721.13 EFE41036.1 - 1.6e-24 87.3 0.0 2.4e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HNH_2 PF13391.6 EFE41037.1 - 6.6e-15 55.0 0.0 1.8e-14 53.6 0.0 1.8 1 0 0 1 1 1 1 HNH endonuclease ketoacyl-synt PF00109.26 EFE41038.1 - 1.2e-64 218.3 1.1 4.5e-64 216.5 0.1 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 EFE41038.1 - 4.9e-62 209.8 0.0 8.2e-62 209.1 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EFE41038.1 - 4.9e-60 203.7 0.1 7.9e-60 203.0 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFE41038.1 - 6.5e-58 195.6 0.9 1.9e-57 194.1 0.9 1.9 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 EFE41038.1 - 3.2e-32 111.0 0.2 9.5e-32 109.5 0.2 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EFE41038.1 - 7.9e-29 100.4 0.0 2e-28 99.1 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EFE41038.1 - 8.4e-13 48.4 0.0 2.5e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFE41038.1 - 6.5e-12 46.7 0.0 3.4e-11 44.3 0.0 2.2 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EFE41038.1 - 4.7e-08 33.0 0.0 1.2e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EFE41038.1 - 6.8e-08 32.7 1.3 1.5e-07 31.7 0.2 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 EFE41038.1 - 1.4e-06 29.0 0.0 4.4e-06 27.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFE41038.1 - 2.4e-06 27.2 1.4 4.6e-06 26.2 0.3 2.0 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_31 PF13847.6 EFE41038.1 - 6e-05 22.9 0.0 0.00031 20.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 EFE41038.1 - 0.00016 21.1 0.3 0.00045 19.7 0.3 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain ADH_N PF08240.12 EFE41038.1 - 0.00021 21.2 0.0 0.0005 19.9 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_11 PF08241.12 EFE41038.1 - 0.00057 20.5 0.0 0.0033 18.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain adh_short_C2 PF13561.6 EFE41038.1 - 0.0023 17.5 0.4 0.064 12.8 0.2 2.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase SAT PF16073.5 EFE41038.1 - 0.043 13.5 0.3 0.9 9.2 0.1 2.4 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis ACP_syn_III PF08545.10 EFE41038.1 - 1.6 8.6 7.5 0.13 12.1 0.6 2.8 3 0 0 3 3 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Aminotran_1_2 PF00155.21 EFE41039.1 - 2.3e-23 83.0 0.0 2.7e-18 66.3 0.0 2.1 1 1 1 2 2 2 2 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFE41039.1 - 8.2e-05 21.3 0.0 0.00014 20.6 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EFE41039.1 - 0.00034 20.0 0.1 0.00056 19.3 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase SHMT PF00464.19 EFE41039.1 - 0.0025 16.5 0.1 0.0038 15.9 0.1 1.2 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 EFE41039.1 - 0.0032 16.8 0.1 0.04 13.2 0.1 2.2 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_3 PF00202.21 EFE41039.1 - 0.0088 14.7 0.0 0.03 13.0 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-III OKR_DC_1 PF01276.20 EFE41039.1 - 0.076 11.7 0.1 1.1 8.0 0.0 2.0 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, major domain p450 PF00067.22 EFE41040.1 - 1.5e-73 248.2 0.0 1.9e-73 247.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 EMP70 PF02990.16 EFE41041.1 - 3.5e-193 643.0 5.5 4.6e-193 642.6 5.5 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 EF-hand_1 PF00036.32 EFE41042.1 - 4.3e-26 88.5 8.7 3.1e-08 32.6 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFE41042.1 - 1.1e-24 86.7 1.2 1.1e-15 57.9 0.6 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFE41042.1 - 1.2e-24 84.0 1.9 3.5e-06 26.5 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFE41042.1 - 2.7e-19 67.7 7.9 2.1e-05 23.8 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EFE41042.1 - 7.9e-16 57.6 9.9 4e-06 26.6 0.9 3.9 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EFE41042.1 - 8.7e-09 35.3 3.4 0.0014 18.5 0.1 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EFE41042.1 - 0.00036 20.8 0.3 0.18 12.2 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFE41042.1 - 0.011 16.0 0.3 0.66 10.3 0.2 2.9 2 2 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EFE41042.1 - 0.033 14.0 1.3 1.5 8.8 0.1 3.2 4 0 0 4 4 4 0 EF hand Med4 PF10018.9 EFE41043.1 - 8.4e-35 120.2 0.1 2.7e-34 118.6 0.1 1.9 2 1 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF3245 PF11595.8 EFE41043.1 - 0.066 13.7 6.5 0.84 10.1 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) DNA_pol_phi PF04931.13 EFE41043.1 - 0.16 10.0 1.3 0.21 9.6 1.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF3295 PF11702.8 EFE41043.1 - 4.7 6.4 8.3 0.15 11.4 2.4 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) MFS_1 PF07690.16 EFE41044.1 - 1.7e-27 96.3 35.8 5.3e-27 94.7 35.6 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily RabGAP-TBC PF00566.18 EFE41045.1 - 7.3e-50 169.6 1.0 1.1e-48 165.7 0.0 2.8 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DUF1664 PF07889.12 EFE41045.1 - 0.014 15.4 3.5 0.014 15.4 3.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) EzrA PF06160.12 EFE41045.1 - 2.1 6.4 15.2 0.47 8.6 0.1 2.8 3 0 0 3 3 3 0 Septation ring formation regulator, EzrA DUF2570 PF10828.8 EFE41045.1 - 7.7 6.4 14.8 0.74 9.7 2.6 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2570) Acyl-CoA_dh_N PF02771.16 EFE41046.1 - 4.5e-23 82.0 0.1 8.3e-23 81.2 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EFE41046.1 - 8.9e-21 74.7 0.7 1.8e-20 73.7 0.7 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFE41046.1 - 2.2e-07 31.0 0.0 4.4e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFE41046.1 - 1.2e-06 28.8 3.0 1.2e-06 28.8 3.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Reticulon PF02453.17 EFE41047.1 - 1e-09 38.6 5.8 1.1e-06 28.7 1.9 2.3 1 1 1 2 2 2 2 Reticulon Phasin_2 PF09361.10 EFE41047.1 - 0.039 14.2 1.2 0.13 12.5 0.3 2.2 2 0 0 2 2 2 0 Phasin protein DNA_topoisoIV PF00521.20 EFE41050.1 - 6.1e-136 453.7 0.1 1.2e-135 452.7 0.1 1.5 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EFE41050.1 - 4.9e-52 175.5 6.8 4.9e-52 175.5 6.8 2.7 3 0 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EFE41050.1 - 1.6e-25 89.6 1.6 1.6e-25 89.6 1.6 2.0 2 0 0 2 2 2 1 DNA gyrase B HATPase_c PF02518.26 EFE41050.1 - 5.7e-15 55.8 0.0 1.7e-14 54.3 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EFE41050.1 - 5.1e-07 29.9 0.0 3.6e-06 27.1 0.0 2.6 1 0 0 1 1 1 1 Toprim domain INCENP_ARK-bind PF03941.15 EFE41051.1 - 2.5e-16 59.3 0.9 2.5e-16 59.3 0.9 2.5 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region PDZ_1 PF12812.7 EFE41052.1 - 7e-53 176.6 0.0 1.8e-34 117.6 0.0 3.3 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.6 EFE41052.1 - 3.4e-21 76.7 0.1 5.3e-20 72.8 0.0 2.4 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 EFE41052.1 - 9.9e-15 54.6 0.1 6e-06 26.5 0.0 3.8 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 EFE41052.1 - 1.2e-14 53.9 3.3 5.9e-07 29.2 0.6 4.7 5 0 0 5 5 5 3 PDZ domain PDZ PF00595.24 EFE41052.1 - 1.9e-10 41.0 0.0 0.00023 21.4 0.0 3.6 3 0 0 3 3 3 3 PDZ domain Trypsin PF00089.26 EFE41052.1 - 0.00019 21.3 0.0 0.00069 19.5 0.0 1.9 1 1 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.6 EFE41052.1 - 0.0013 18.7 0.3 0.38 10.8 0.2 3.8 4 0 0 4 4 4 1 Tricorn protease PDZ domain 4HPAD_g_N PF18671.1 EFE41052.1 - 0.057 13.1 0.0 0.18 11.5 0.0 1.9 1 0 0 1 1 1 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal DUF31 PF01732.16 EFE41052.1 - 0.12 11.8 0.3 0.2 11.2 0.3 1.3 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S46 PF10459.9 EFE41052.1 - 0.23 10.0 1.5 0.28 9.8 0.1 1.7 2 0 0 2 2 2 0 Peptidase S46 Lactamase_B PF00753.27 EFE41054.1 - 3.5e-06 27.2 0.3 5.7e-06 26.5 0.3 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily But2 PF09792.9 EFE41055.1 - 2.7e-47 160.8 0.2 3.4e-47 160.4 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain DUF5640 PF18692.1 EFE41055.1 - 0.12 12.4 0.1 0.64 10.1 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5640) PAP2 PF01569.21 EFE41056.1 - 5.8e-23 81.2 3.7 3.3e-21 75.5 3.7 2.1 1 1 0 1 1 1 1 PAP2 superfamily Trypsin PF00089.26 EFE41058.1 - 0.06 13.1 0.1 0.061 13.1 0.1 1.1 1 0 0 1 1 1 0 Trypsin MARVEL PF01284.23 EFE41059.1 - 0.0049 16.9 5.9 0.0064 16.5 5.9 1.3 1 0 0 1 1 1 1 Membrane-associating domain Kei1 PF08552.11 EFE41059.1 - 0.023 14.6 0.0 0.036 14.0 0.0 1.4 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 UPF0182 PF03699.13 EFE41059.1 - 0.062 11.4 0.4 0.083 11.0 0.2 1.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) SelK_SelG PF10961.8 EFE41059.1 - 0.92 10.2 3.7 0.91 10.2 0.2 2.4 2 1 1 3 3 3 0 Selenoprotein SelK_SelG MOSC PF03473.17 EFE41060.1 - 9.5e-31 106.5 0.0 1.6e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 MOSC domain Aminotran_5 PF00266.19 EFE41060.1 - 2.5e-25 89.2 0.0 3.9e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V MOSC_N PF03476.16 EFE41060.1 - 1.2e-24 86.5 0.0 2.1e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Mitoc_mL59 PF18126.1 EFE41061.1 - 3.7e-49 166.3 1.9 6.7e-49 165.5 1.9 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 TPR_14 PF13428.6 EFE41063.1 - 0.005 17.6 0.4 0.005 17.6 0.4 4.9 5 1 1 6 6 6 1 Tetratricopeptide repeat c-SKI_SMAD_bind PF08782.10 EFE41063.1 - 0.0051 17.0 1.6 0.95 9.7 0.1 3.2 2 1 1 3 3 3 1 c-SKI Smad4 binding domain DUF4810 PF16068.5 EFE41063.1 - 0.018 15.6 0.1 2.2 8.9 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4810) FAT PF02259.23 EFE41063.1 - 0.025 13.8 0.2 0.13 11.4 0.0 2.1 1 1 1 3 3 3 0 FAT domain ANAPC15 PF15243.6 EFE41063.1 - 0.11 12.9 0.8 0.47 10.9 0.2 2.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 15 FAD_binding_4 PF01565.23 EFE41064.1 - 3e-16 59.4 4.5 9e-12 44.9 0.8 2.8 1 1 1 2 2 2 2 FAD binding domain PNPase_C PF12111.8 EFE41064.1 - 3.9 7.0 6.5 7.7 6.0 4.2 2.3 2 0 0 2 2 2 0 Polyribonucleotide phosphorylase C terminal p450 PF00067.22 EFE41065.1 - 2.4e-13 49.7 0.2 8e-11 41.3 0.1 2.0 2 0 0 2 2 2 2 Cytochrome P450 DEAD PF00270.29 EFE41068.1 - 3.5e-46 157.2 0.0 1.3e-45 155.3 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE41068.1 - 4.5e-30 104.3 0.1 2e-29 102.2 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE41068.1 - 0.007 16.4 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PRAI PF00697.22 EFE41068.1 - 0.019 14.7 0.0 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase DUF2986 PF11661.8 EFE41068.1 - 2.3 8.8 10.0 0.13 12.8 3.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2986) Neur_chan_memb PF02932.16 EFE41068.1 - 8.8 6.3 5.2 21 5.0 5.2 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ERAP1_C PF11838.8 EFE41069.1 - 2.7e-85 286.7 0.5 2.5e-83 280.3 0.1 2.4 2 0 0 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EFE41069.1 - 4.3e-84 281.4 3.0 7e-84 280.8 3.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EFE41069.1 - 1.2e-52 178.9 1.2 2.1e-52 178.0 1.2 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DUF2808 PF10989.8 EFE41069.1 - 0.014 15.4 0.0 0.036 14.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) AA_permease_2 PF13520.6 EFE41071.1 - 3e-87 293.2 37.0 4.8e-87 292.5 37.0 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE41071.1 - 8.7e-24 83.9 31.4 1.6e-23 83.1 31.4 1.4 1 1 0 1 1 1 1 Amino acid permease DUF3543 PF12063.8 EFE41072.1 - 4.1e-94 314.6 0.0 7.2e-94 313.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 EFE41072.1 - 1.6e-61 208.0 0.0 3.9e-61 206.7 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41072.1 - 1e-42 146.3 0.0 2.5e-42 145.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE41072.1 - 0.14 12.0 0.1 0.14 12.0 0.1 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Gly-zipper_Omp PF13488.6 EFE41073.1 - 0.17 11.9 1.0 0.27 11.3 1.0 1.2 1 0 0 1 1 1 0 Glycine zipper YihI PF04220.12 EFE41074.1 - 0.19 11.4 1.5 1.6 8.4 0.1 2.2 2 0 0 2 2 2 0 Der GTPase activator (YihI) DHHC PF01529.20 EFE41074.1 - 1.3 9.1 4.6 0.74 9.9 1.6 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase MFS_Mycoplasma PF07672.13 EFE41074.1 - 1.6 7.9 5.4 0.84 8.9 0.6 2.4 2 0 0 2 2 2 0 Mycoplasma MFS transporter Diphthami_syn_2 PF01902.17 EFE41076.1 - 5.8e-18 65.2 0.0 1.3e-07 31.4 0.0 4.2 2 1 0 2 2 2 2 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EFE41076.1 - 4.6e-11 42.8 0.0 1.5e-05 25.0 0.0 3.7 3 1 0 3 3 3 2 Endoribonuclease L-PSP zf-C2H2 PF00096.26 EFE41077.1 - 2.5e-10 40.2 19.8 1.5e-06 28.4 0.9 3.1 3 0 0 3 3 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EFE41077.1 - 2.1e-06 27.8 3.2 0.013 15.8 0.5 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EFE41077.1 - 4e-06 27.0 3.5 4e-06 27.0 3.5 4.0 5 0 0 5 5 5 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE41077.1 - 9.2e-06 26.1 16.5 0.0067 17.2 0.4 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFE41077.1 - 0.0005 20.0 9.0 0.021 14.8 0.7 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EFE41077.1 - 0.0014 18.9 10.2 0.0085 16.4 0.3 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-LYAR PF08790.11 EFE41077.1 - 0.0057 16.5 3.5 0.2 11.6 0.5 2.6 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf-UBR PF02207.20 EFE41077.1 - 0.12 12.6 0.7 0.29 11.3 0.7 1.6 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf_C2H2_ZHX PF18387.1 EFE41077.1 - 0.21 11.2 8.0 1.3 8.7 0.4 3.4 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf_UBZ PF18439.1 EFE41077.1 - 0.34 10.6 1.9 1.2 8.8 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_2 PF12756.7 EFE41077.1 - 0.38 11.1 4.1 9.5 6.6 0.3 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 EFE41077.1 - 0.69 10.6 4.9 5.5 7.7 0.3 3.1 2 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-trcl PF13451.6 EFE41077.1 - 0.86 9.5 4.2 0.88 9.5 0.6 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf-C2H2_11 PF16622.5 EFE41077.1 - 0.92 9.3 8.5 7.7 6.4 0.1 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EFE41077.1 - 2.8 8.1 4.5 7 6.9 0.6 2.5 1 1 1 2 2 2 0 Zinc ribbon domain DUF629 PF04780.12 EFE41077.1 - 2.9 6.3 4.5 14 4.1 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2HE PF16278.5 EFE41077.1 - 6.2 7.3 6.8 5.7e+02 1.1 7.0 2.6 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger PITH PF06201.13 EFE41078.1 - 7.6e-36 123.6 0.0 9.7e-36 123.3 0.0 1.1 1 0 0 1 1 1 1 PITH domain zf-CSL PF05207.13 EFE41079.1 - 1.2e-18 66.5 1.0 2.2e-18 65.7 1.0 1.5 1 1 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EFE41079.1 - 9.8e-13 48.0 0.3 5.4e-08 32.8 0.1 2.3 2 0 0 2 2 2 2 DnaJ domain ERG2_Sigma1R PF04622.12 EFE41080.1 - 2.4e-58 196.9 0.9 2.9e-58 196.6 0.9 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein peroxidase PF00141.23 EFE41081.1 - 1.4e-49 168.9 0.0 2.1e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Mid2 PF04478.12 EFE41084.1 - 0.0011 18.8 0.1 0.0026 17.6 0.1 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor DUF3445 PF11927.8 EFE41085.1 - 3.1e-81 272.3 0.0 3.9e-81 272.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) RSN1_7TM PF02714.15 EFE41087.1 - 4.5e-77 259.0 23.9 6.8e-77 258.5 23.9 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EFE41087.1 - 1.4e-42 145.9 0.0 2.3e-42 145.2 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EFE41087.1 - 4.7e-40 136.9 0.6 4.7e-40 136.9 0.6 2.3 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport Bradykinin PF06753.12 EFE41087.1 - 6.2 6.7 6.1 0.42 10.4 0.2 2.1 2 0 0 2 2 2 0 Bradykinin DUF4366 PF14283.6 EFE41088.1 - 0.053 13.6 0.8 0.053 13.6 0.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) SDA1 PF05285.12 EFE41088.1 - 0.14 11.5 30.2 0.2 11.1 30.2 1.2 1 0 0 1 1 1 0 SDA1 Sporozoite_P67 PF05642.11 EFE41088.1 - 0.37 8.8 9.8 0.48 8.4 9.8 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Presenilin PF01080.17 EFE41088.1 - 0.59 8.8 9.7 0.71 8.6 9.7 1.1 1 0 0 1 1 1 0 Presenilin Afi1 PF07792.12 EFE41088.1 - 0.75 10.3 17.0 0.2 12.1 4.8 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF1168 PF06658.12 EFE41088.1 - 1.6 8.5 27.9 1.4 8.7 9.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) DUF2956 PF11169.8 EFE41088.1 - 2.1 8.6 14.9 0.22 11.8 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) BSP_II PF05432.11 EFE41088.1 - 2.6 7.6 29.4 0.47 10.1 13.1 2.0 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Pinin_SDK_memA PF04696.13 EFE41088.1 - 6.3 6.9 24.1 0.3 11.1 9.4 2.1 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region zf-C2H2 PF00096.26 EFE41090.1 - 0.00014 22.1 21.4 0.46 11.0 1.0 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE41090.1 - 0.4 11.7 23.3 0.82 10.7 0.6 5.2 5 1 0 5 5 5 0 C2H2-type zinc finger FOXP-CC PF16159.5 EFE41090.1 - 1.2 9.9 5.4 22 5.8 0.4 3.4 3 0 0 3 3 3 0 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 EFE41090.1 - 2.2 8.1 4.6 1.1e+02 2.7 0.0 3.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain RPN7 PF10602.9 EFE41091.1 - 2.2e-51 174.0 0.1 3.9e-51 173.2 0.1 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EFE41091.1 - 4.5e-10 40.0 0.1 1.6e-09 38.2 0.1 2.0 1 0 0 1 1 1 1 PCI domain DSBA PF01323.20 EFE41092.1 - 1e-10 41.7 0.0 1.3e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain adh_short PF00106.25 EFE41093.1 - 7.6e-28 97.3 0.6 1.7e-18 66.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFE41093.1 - 2.1e-21 76.6 0.0 1.5e-16 60.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE41093.1 - 0.00026 20.9 0.0 0.00042 20.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 EFE41093.1 - 0.069 12.9 0.0 2.1 8.1 0.1 2.3 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.19 EFE41093.1 - 0.094 12.0 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NEMP PF10225.9 EFE41094.1 - 0.023 14.4 0.2 0.023 14.4 0.2 2.7 2 1 0 2 2 2 0 NEMP family OrfB_IS605 PF01385.19 EFE41095.1 - 0.37 11.0 2.9 8.7 6.6 0.1 2.8 1 1 1 2 2 2 0 Probable transposase Nup54 PF13874.6 EFE41095.1 - 0.88 9.7 8.1 0.36 10.9 1.4 2.5 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Peptidase_M1_N PF17900.1 EFE41096.1 - 0.00062 20.0 0.0 1.5 9.0 0.0 2.6 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 EFE41096.1 - 0.0019 17.8 0.0 0.0042 16.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3439 PF11921.8 EFE41096.1 - 9.6 6.2 7.8 24 4.9 7.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CD225 PF04505.12 EFE41097.1 - 0.0059 16.7 0.2 0.076 13.2 0.4 2.1 2 0 0 2 2 2 1 Interferon-induced transmembrane protein PRCH PF03967.13 EFE41097.1 - 0.23 11.7 0.2 0.35 11.1 0.2 1.3 1 0 0 1 1 1 0 Photosynthetic reaction centre, H-chain N-terminal region PALP PF00291.25 EFE41099.1 - 1.4e-37 129.7 0.1 1.7e-37 129.4 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4187 PF13821.6 EFE41100.1 - 8e-22 76.8 1.3 2.9e-21 75.0 1.3 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 EFE41100.1 - 2.3e-10 40.2 1.9 1.3e-08 34.6 1.9 3.0 2 1 0 2 2 2 1 G-patch domain ATP_transf PF09830.9 EFE41107.1 - 1.4e-23 82.8 0.2 2.5e-23 82.0 0.2 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4931 PF16285.5 EFE41107.1 - 0.086 12.1 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4931) GalP_UDP_transf PF01087.22 EFE41107.1 - 0.11 12.9 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, N-terminal domain HIT PF01230.23 EFE41107.1 - 0.14 12.9 0.1 0.35 11.6 0.1 1.7 1 0 0 1 1 1 0 HIT domain JCAD PF15351.6 EFE41108.1 - 0.034 11.9 1.9 0.038 11.8 1.9 1.0 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease TssO PF17561.2 EFE41108.1 - 0.039 14.1 0.5 0.054 13.6 0.5 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssO GRP PF07172.11 EFE41108.1 - 0.088 13.5 0.0 0.12 13.1 0.0 1.2 1 0 0 1 1 1 0 Glycine rich protein family DUF4604 PF15377.6 EFE41108.1 - 0.43 11.0 7.2 0.56 10.6 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Phage_Gp23 PF10669.9 EFE41108.1 - 0.59 10.5 0.1 0.59 10.5 0.1 1.9 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) ABC_tran PF00005.27 EFE41109.1 - 5.8e-46 156.4 0.7 2.4e-22 79.9 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 EFE41109.1 - 1.6e-21 76.2 6.9 1.6e-21 76.2 6.9 3.8 5 0 0 5 5 3 1 ABC transporter AAA_21 PF13304.6 EFE41109.1 - 4.8e-16 59.4 0.8 0.0031 17.4 0.0 4.8 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFE41109.1 - 4.5e-11 42.6 0.2 0.0096 15.4 0.0 4.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFE41109.1 - 1.2e-06 28.5 4.9 0.26 11.0 0.0 4.9 5 0 0 5 5 5 2 AAA ATPase domain MMR_HSR1 PF01926.23 EFE41109.1 - 9.7e-06 25.6 0.0 0.14 12.3 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFE41109.1 - 1.1e-05 25.4 0.2 0.12 12.3 0.1 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EFE41109.1 - 1.4e-05 25.4 0.0 0.026 14.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFE41109.1 - 2.9e-05 24.5 0.4 0.24 11.8 0.2 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EFE41109.1 - 3.6e-05 23.4 0.2 0.34 10.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_18 PF13238.6 EFE41109.1 - 4.9e-05 23.9 2.5 0.45 11.1 0.0 3.6 4 0 0 4 4 3 2 AAA domain AAA_28 PF13521.6 EFE41109.1 - 0.00045 20.5 2.5 0.29 11.4 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_24 PF13479.6 EFE41109.1 - 0.00046 20.0 0.9 1 9.0 0.1 3.0 3 0 0 3 3 2 2 AAA domain AAA_23 PF13476.6 EFE41109.1 - 0.0008 20.0 0.2 0.018 15.5 0.0 5.2 5 1 0 5 5 4 2 AAA domain AAA_30 PF13604.6 EFE41109.1 - 0.00083 19.1 3.7 0.029 14.1 0.0 3.9 3 1 0 3 3 3 1 AAA domain AAA PF00004.29 EFE41109.1 - 0.004 17.6 0.0 1.3 9.5 0.1 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_27 PF13514.6 EFE41109.1 - 0.0052 16.4 0.1 4.1 7.0 0.0 3.2 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 EFE41109.1 - 0.0062 16.5 0.1 1.6 8.6 0.0 2.6 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EFE41109.1 - 0.013 15.9 0.1 7 7.1 0.0 2.9 3 0 0 3 3 2 0 RNA helicase Zeta_toxin PF06414.12 EFE41109.1 - 0.023 14.0 1.7 4.3 6.6 0.1 3.1 3 0 0 3 3 3 0 Zeta toxin AAA_14 PF13173.6 EFE41109.1 - 0.027 14.5 0.0 16 5.5 0.0 3.0 2 0 0 2 2 2 0 AAA domain Peripla_BP_3 PF13377.6 EFE41109.1 - 0.03 14.6 0.1 32 4.8 0.0 3.4 3 0 0 3 3 3 0 Periplasmic binding protein-like domain Rad17 PF03215.15 EFE41109.1 - 0.034 14.1 0.2 1.9 8.4 0.0 3.0 3 0 0 3 3 3 0 Rad17 P-loop domain cobW PF02492.19 EFE41109.1 - 0.041 13.5 0.4 2.4 7.7 0.4 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 EFE41109.1 - 0.058 13.6 0.1 11 6.3 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 EFE41109.1 - 0.06 12.3 3.6 4.4 6.2 0.0 2.9 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EFE41109.1 - 0.063 13.2 0.1 3.7 7.4 0.0 2.9 2 0 0 2 2 2 0 NTPase DUF2813 PF11398.8 EFE41109.1 - 0.1 11.9 1.5 0.27 10.5 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) AAA_5 PF07728.14 EFE41109.1 - 0.1 12.6 0.2 23 5.0 0.0 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EFE41109.1 - 0.16 12.2 12.1 0.72 10.0 0.0 3.6 4 1 0 4 4 2 0 AAA domain DUF3385 PF11865.8 EFE41109.1 - 0.17 11.8 0.3 0.59 10.0 0.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3385) Dynamin_N PF00350.23 EFE41109.1 - 1 9.4 12.6 2.5 8.2 0.0 4.2 5 1 0 5 5 4 0 Dynamin family Guanylate_kin PF00625.21 EFE41110.1 - 1.4e-47 161.8 0.0 1.6e-47 161.5 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase MFS_1 PF07690.16 EFE41111.1 - 2.8e-40 138.3 39.9 3.5e-40 138.0 39.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF639 PF04842.12 EFE41111.1 - 0.17 11.3 0.7 0.25 10.7 0.1 1.6 2 0 0 2 2 2 0 Plant protein of unknown function (DUF639) Sugar_tr PF00083.24 EFE41112.1 - 3.7e-74 250.2 22.7 1.4e-60 205.4 6.7 2.7 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFE41112.1 - 1e-13 51.0 20.1 1.9e-08 33.7 1.1 3.3 1 1 1 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFE41112.1 - 0.00035 19.5 7.5 0.0012 17.7 0.2 2.7 3 0 0 3 3 3 2 MFS_1 like family LacY_symp PF01306.19 EFE41112.1 - 0.049 12.4 4.7 0.5 9.1 0.5 2.2 2 0 0 2 2 2 0 LacY proton/sugar symporter SKG6 PF08693.10 EFE41113.1 - 0.033 13.6 0.4 0.062 12.7 0.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain YjeF_N PF03853.15 EFE41114.1 - 5.1e-34 117.6 0.1 8e-34 117.0 0.1 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EFE41114.1 - 1.7e-06 28.9 0.4 1.7e-06 28.9 0.4 2.6 3 0 0 3 3 3 1 FDF domain OCD_Mu_crystall PF02423.15 EFE41114.1 - 0.037 13.0 0.2 1 8.2 0.0 2.1 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family Pkinase PF00069.25 EFE41115.1 - 6.4e-17 61.8 0.2 2.3e-14 53.4 0.1 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41115.1 - 6.1e-10 38.8 0.0 2.5e-07 30.3 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase RIO1 PF01163.22 EFE41115.1 - 5.1e-06 26.2 0.1 9e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pro_isomerase PF00160.21 EFE41116.1 - 5.6e-41 140.5 0.0 9.9e-41 139.6 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-NOSIP PF15906.5 EFE41116.1 - 0.00021 21.4 0.0 0.00053 20.1 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 EFE41116.1 - 0.00066 19.1 2.0 0.0024 17.3 0.3 2.5 2 1 0 2 2 2 1 Rtf2 RING-finger U-box PF04564.15 EFE41116.1 - 0.0022 18.2 0.0 0.0098 16.0 0.0 2.0 1 1 0 1 1 1 1 U-box domain PIF1 PF05970.14 EFE41118.1 - 7.4e-64 216.2 0.1 1.1e-63 215.6 0.1 1.3 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 EFE41118.1 - 5.5e-25 88.2 0.0 1e-24 87.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFE41118.1 - 2.7e-11 44.0 0.1 5.4e-10 39.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFE41118.1 - 9.3e-09 35.7 0.0 2.6e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EFE41118.1 - 3.5e-05 23.4 0.2 0.0001 21.9 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 EFE41118.1 - 0.00019 21.9 0.4 0.00057 20.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 EFE41118.1 - 0.00024 20.9 0.1 0.00075 19.3 0.1 1.9 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 EFE41118.1 - 0.00025 19.1 0.0 0.0011 17.1 0.0 1.8 2 0 0 2 2 2 1 Helicase Viral_helicase1 PF01443.18 EFE41118.1 - 0.00028 20.7 0.2 0.092 12.5 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 EFE41118.1 - 0.0052 16.8 0.2 0.029 14.4 0.1 2.4 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFE41118.1 - 0.0087 15.3 0.3 0.017 14.3 0.3 1.4 1 0 0 1 1 1 1 NB-ARC domain DUF2075 PF09848.9 EFE41118.1 - 0.0093 15.2 0.1 0.041 13.1 0.1 2.1 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EFE41118.1 - 0.016 15.6 0.1 0.054 13.9 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EFE41118.1 - 0.016 15.2 0.2 0.073 13.1 0.2 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) PhoH PF02562.16 EFE41118.1 - 0.018 14.5 0.0 0.045 13.2 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein RsgA_GTPase PF03193.16 EFE41118.1 - 0.039 13.8 0.2 0.092 12.6 0.2 1.6 1 0 0 1 1 1 0 RsgA GTPase ATPase_2 PF01637.18 EFE41118.1 - 0.05 13.5 1.2 0.3 11.0 1.2 2.1 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea SH3_13 PF18335.1 EFE41118.1 - 0.055 13.3 0.0 0.23 11.3 0.0 2.1 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain T2SSE PF00437.20 EFE41118.1 - 0.07 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF5605 PF18310.1 EFE41118.1 - 0.073 13.0 0.0 0.27 11.1 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) RNA_helicase PF00910.22 EFE41118.1 - 0.087 13.2 0.0 0.34 11.3 0.0 2.2 1 1 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EFE41118.1 - 0.088 12.5 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EFE41118.1 - 0.12 12.8 1.2 0.26 11.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFE41118.1 - 0.14 12.2 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFE41118.1 - 0.14 12.1 0.0 0.29 11.1 0.0 1.6 1 1 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EFE41118.1 - 0.38 11.3 2.7 0.57 10.7 0.1 2.6 2 1 1 3 3 3 0 ABC transporter PTCB-BRCT PF12738.7 EFE41119.1 - 1e-31 108.6 1.6 5.1e-16 58.4 0.3 3.5 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.26 EFE41119.1 - 2.1e-20 72.9 0.8 2.5e-07 31.0 0.0 4.6 4 1 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFE41119.1 - 3.5e-09 37.0 0.0 0.0031 17.9 0.0 3.6 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EFE41119.1 - 0.0011 19.2 4.0 0.78 10.1 0.0 4.0 4 0 0 4 4 4 2 DNA ligase 3 BRCT domain Dynamin_N PF00350.23 EFE41120.1 - 2.1e-18 66.9 0.8 3e-17 63.2 0.1 2.9 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EFE41120.1 - 1.3e-10 41.4 0.0 1.1e-08 35.1 0.0 3.4 3 1 0 3 3 3 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFE41120.1 - 1.4e-07 31.3 0.1 9.4e-05 22.0 0.1 2.7 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF2205 PF10224.9 EFE41120.1 - 0.053 13.5 0.1 0.19 11.8 0.1 1.9 1 0 0 1 1 1 0 Short coiled-coil protein FeoB_N PF02421.18 EFE41120.1 - 0.057 12.9 0.3 40 3.7 0.0 3.9 5 0 0 5 5 5 0 Ferrous iron transport protein B AAA_18 PF13238.6 EFE41120.1 - 0.074 13.6 0.0 0.6 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFE41120.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 EFE41120.1 - 0.16 11.8 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EFE41120.1 - 0.16 12.2 0.0 3 8.1 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase BrkDBD PF09607.10 EFE41123.1 - 0.069 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Brinker DNA-binding domain DUF1158 PF06643.11 EFE41123.1 - 0.14 12.7 0.0 0.37 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1158) Lon_C PF05362.13 EFE41124.1 - 4.1e-63 212.7 0.0 7.4e-63 211.8 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EFE41124.1 - 6.3e-36 124.2 0.1 1.4e-35 123.1 0.1 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EFE41124.1 - 6.8e-22 78.3 0.0 1.8e-21 77.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFE41124.1 - 6.9e-07 29.3 0.0 1.5e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EFE41124.1 - 4.4e-06 26.5 0.0 1.1e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 EFE41124.1 - 5e-06 26.7 0.0 1.4e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_PrkA PF08298.11 EFE41124.1 - 2.8e-05 23.2 0.1 8.2e-05 21.7 0.0 1.7 2 0 0 2 2 2 1 PrkA AAA domain AAA_22 PF13401.6 EFE41124.1 - 2.9e-05 24.3 0.0 0.00029 21.1 0.0 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFE41124.1 - 3.9e-05 23.4 0.8 0.00077 19.2 0.0 3.1 4 0 0 4 4 4 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFE41124.1 - 0.00054 20.4 2.0 0.0025 18.2 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain NTPase_1 PF03266.15 EFE41124.1 - 0.019 14.9 0.2 1.5 8.7 0.0 3.2 2 1 1 3 3 3 0 NTPase AAA_14 PF13173.6 EFE41124.1 - 0.031 14.3 0.0 0.08 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFE41124.1 - 0.042 13.6 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFE41124.1 - 0.043 13.7 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase IstB_IS21 PF01695.17 EFE41124.1 - 0.044 13.5 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 EFE41124.1 - 0.076 13.6 0.0 0.076 13.6 0.0 2.8 3 0 0 3 3 2 0 AAA domain F-box-like_2 PF13013.6 EFE41124.1 - 0.097 12.6 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 F-box-like domain AAA_7 PF12775.7 EFE41124.1 - 0.099 12.2 0.5 0.19 11.3 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EFE41124.1 - 0.1 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase SKI PF01202.22 EFE41124.1 - 0.13 12.4 1.0 0.44 10.7 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase DUF445 PF04286.12 EFE41124.1 - 0.75 9.5 7.2 0.32 10.7 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF445) SPX PF03105.19 EFE41124.1 - 1.5 8.7 10.5 0.51 10.2 1.8 2.6 3 0 0 3 3 3 0 SPX domain ABC_tran PF00005.27 EFE41124.1 - 1.9 9.0 5.2 0.97 9.9 0.1 2.8 3 0 0 3 3 3 0 ABC transporter DnaJ_C PF01556.18 EFE41125.1 - 1.6e-36 125.6 0.0 2.2e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFE41125.1 - 9.8e-22 76.9 0.4 3.8e-21 75.0 0.2 2.0 2 0 0 2 2 2 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFE41125.1 - 1.2e-09 38.4 21.4 1.2e-09 38.4 21.4 2.1 2 0 0 2 2 2 1 DnaJ central domain HypA PF01155.19 EFE41125.1 - 0.31 11.1 8.8 0.088 12.8 1.2 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 EFE41125.1 - 2.8 8.0 19.7 0.2 11.7 5.2 2.9 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein BRO1 PF03097.18 EFE41127.1 - 2.7e-130 434.7 0.5 2.7e-130 434.7 0.5 2.0 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EFE41127.1 - 1.9e-77 260.4 15.7 3.7e-77 259.5 15.7 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF3232 PF11554.8 EFE41127.1 - 0.046 14.1 0.4 0.046 14.1 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3232) DUF2383 PF09537.10 EFE41127.1 - 0.048 14.0 3.1 1.5 9.2 0.6 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF2383) SAP30_Sin3_bdg PF13867.6 EFE41128.1 - 1.7e-09 37.8 0.1 5.4e-09 36.3 0.0 1.9 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 F-box PF00646.33 EFE41129.1 - 4.7e-08 32.7 0.1 1.5e-06 27.9 0.2 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFE41129.1 - 0.00023 21.0 0.2 0.046 13.6 0.2 2.7 2 0 0 2 2 2 2 F-box-like F-box_4 PF15966.5 EFE41129.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 F-box Apt1 PF10351.9 EFE41131.1 - 0.2 10.5 5.4 0.24 10.2 5.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain zf-C2H2 PF00096.26 EFE41132.1 - 9.9e-07 28.9 12.8 0.0029 18.0 4.4 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE41132.1 - 2.6e-05 24.4 8.2 4.5e-05 23.7 2.0 4.1 3 1 0 3 3 3 2 Zinc-finger double domain RED_N PF07808.13 EFE41133.1 - 3.2e-08 33.4 3.8 3.2e-08 33.4 3.8 2.7 3 1 0 3 3 3 1 RED-like protein N-terminal region Glyco_hydro_cc PF11790.8 EFE41134.1 - 1.7e-61 207.9 0.5 2e-61 207.6 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Peptidase_S8 PF00082.22 EFE41135.1 - 5.8e-37 127.6 1.1 8.5e-37 127.0 1.1 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EFE41135.1 - 1.3e-25 89.2 0.9 2.6e-25 88.2 0.9 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain FYRN PF05964.14 EFE41136.1 - 0.032 14.1 0.0 12 5.8 0.0 2.3 2 0 0 2 2 2 0 F/Y-rich N-terminus Rimk_N PF18030.1 EFE41136.1 - 0.1 13.0 0.0 8.5 6.8 0.0 3.1 1 1 2 3 3 3 0 RimK PreATP-grasp domain Tox-GHH PF15636.6 EFE41136.1 - 0.11 12.5 0.0 23 5.0 0.0 2.3 2 0 0 2 2 2 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin Unstab_antitox PF09720.10 EFE41136.1 - 0.14 12.3 0.1 25 5.0 0.0 2.3 2 0 0 2 2 2 0 Putative addiction module component DUF3328 PF11807.8 EFE41137.1 - 1.6e-24 86.9 4.1 2.2e-24 86.5 4.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Methyltransf_2 PF00891.18 EFE41138.1 - 1.6e-27 96.2 0.0 2.5e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 EFE41138.1 - 4.1e-05 23.5 0.0 6.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE41138.1 - 8.2e-05 23.2 0.6 0.0015 19.2 0.0 3.0 4 0 0 4 4 4 1 Methyltransferase domain CheR PF01739.18 EFE41138.1 - 0.0094 15.5 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain MTS PF05175.14 EFE41138.1 - 0.046 13.3 0.0 0.1 12.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Myb_DNA-binding PF00249.31 EFE41139.1 - 7.5e-05 22.8 0.1 0.00013 22.0 0.1 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFE41139.1 - 0.023 14.9 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFE41140.1 - 8.9e-17 61.0 0.3 1.1e-11 44.7 0.2 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFE41140.1 - 2.4e-14 53.3 0.1 2.8e-14 53.1 0.1 1.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Rap1_C PF11626.8 EFE41140.1 - 0.0055 16.8 0.0 2.2 8.4 0.0 2.1 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_4 PF13837.6 EFE41140.1 - 0.034 14.5 0.7 0.085 13.3 0.5 1.7 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain FAD_binding_4 PF01565.23 EFE41141.1 - 1.5e-24 86.3 0.1 2.6e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain PsbT PF01405.17 EFE41141.1 - 0.11 12.3 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre T protein adh_short PF00106.25 EFE41142.1 - 3.5e-45 153.9 0.3 4.6e-45 153.5 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE41142.1 - 1.3e-31 110.0 0.3 1.8e-31 109.5 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE41142.1 - 2.8e-09 37.2 0.2 4.7e-09 36.4 0.2 1.4 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EFE41142.1 - 1.8e-05 24.2 0.0 2.9e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 EFE41142.1 - 0.0015 18.5 0.3 0.0036 17.2 0.2 1.8 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFE41142.1 - 0.059 12.9 0.1 6.9 6.2 0.1 2.2 2 0 0 2 2 2 0 NmrA-like family AA_permease PF00324.21 EFE41143.1 - 3.6e-118 395.2 36.7 4.2e-118 395.0 36.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE41143.1 - 8.5e-29 100.6 41.5 1.1e-28 100.2 41.5 1.2 1 0 0 1 1 1 1 Amino acid permease KGG PF10685.9 EFE41144.1 - 3.5e-25 87.5 15.7 5.1e-10 39.3 0.5 3.2 3 0 0 3 3 3 3 Stress-induced bacterial acidophilic repeat motif Aminotran_5 PF00266.19 EFE41145.1 - 3.1e-16 59.3 0.0 5.5e-15 55.2 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V EutN_CcmL PF03319.13 EFE41145.1 - 0.15 12.6 0.0 0.36 11.5 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutN/carboxysome UNC-93 PF05978.16 EFE41146.1 - 7.9e-06 25.7 2.1 7.9e-06 25.7 2.1 2.0 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 CcmE PF03100.15 EFE41146.1 - 0.13 12.3 0.3 0.29 11.1 0.3 1.6 1 0 0 1 1 1 0 CcmE WD40 PF00400.32 EFE41147.1 - 1.8e-27 95.0 6.0 2.2e-06 28.3 0.1 5.9 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE41147.1 - 5.3e-09 36.3 0.0 0.011 16.0 0.0 3.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE41147.1 - 5.8e-05 21.9 0.0 0.023 13.4 0.0 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFE41147.1 - 0.12 11.3 0.0 4.3 6.2 0.0 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Exo_endo_phos PF03372.23 EFE41148.1 - 7.9e-14 51.7 0.1 1.2e-13 51.2 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Thi4 PF01946.17 EFE41149.1 - 3.4e-108 360.3 0.0 4.1e-108 360.0 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EFE41149.1 - 6.5e-07 29.2 0.0 7.5e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE41149.1 - 1.3e-05 25.3 0.1 8e-05 22.8 0.1 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EFE41149.1 - 0.0002 20.6 0.3 0.00034 19.8 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EFE41149.1 - 0.0018 17.6 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFE41149.1 - 0.0036 17.3 0.2 0.015 15.3 0.1 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EFE41149.1 - 0.078 11.8 0.2 0.11 11.3 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.19 EFE41149.1 - 0.089 12.0 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.24 EFE41149.1 - 0.13 11.4 0.3 0.31 10.1 0.3 1.6 2 0 0 2 2 2 0 FAD binding domain Ppx-GppA PF02541.16 EFE41151.1 - 1.2e-40 139.7 0.0 1.2e-39 136.5 0.0 2.0 1 1 0 1 1 1 1 Ppx/GppA phosphatase family Proteasome PF00227.26 EFE41152.1 - 1.2e-46 158.6 0.1 1.4e-46 158.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit CMV_US PF08001.11 EFE41152.1 - 0.065 12.5 0.0 0.09 12.0 0.0 1.1 1 0 0 1 1 1 0 CMV US SWI-SNF_Ssr4 PF08549.10 EFE41153.1 - 8.8e-178 593.3 11.0 3.4e-177 591.3 11.0 1.7 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1750) MRPL52 PF18699.1 EFE41153.1 - 0.51 10.6 2.5 0.41 10.8 0.2 2.0 2 0 0 2 2 2 0 Mitoribosomal protein mL52 RNA_pol_Rpb2_6 PF00562.28 EFE41154.1 - 6.5e-116 387.6 0.0 8.7e-116 387.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFE41154.1 - 1.7e-38 132.2 0.0 2.6e-38 131.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EFE41154.1 - 1.3e-27 95.8 0.0 3.1e-27 94.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 EFE41154.1 - 3e-27 95.5 0.0 5.3e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.12 EFE41154.1 - 1.5e-25 88.9 0.0 3.5e-25 87.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 EFE41154.1 - 1.2e-15 57.6 0.0 2.7e-14 53.3 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 KR PF08659.10 EFE41155.1 - 9.4e-58 195.1 0.1 1.8e-57 194.2 0.1 1.5 1 0 0 1 1 1 1 KR domain ketoacyl-synt PF00109.26 EFE41155.1 - 4e-34 118.3 0.0 7.2e-34 117.5 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ADH_zinc_N_2 PF13602.6 EFE41155.1 - 8.1e-14 52.8 0.0 2.3e-13 51.4 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFE41155.1 - 2.6e-13 50.1 0.0 5.6e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EFE41155.1 - 3.2e-10 39.8 0.0 6.3e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase ADH_N PF08240.12 EFE41155.1 - 0.00068 19.5 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EFE41155.1 - 0.0016 18.8 0.0 0.0036 17.6 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EFE41155.1 - 0.0023 17.5 0.0 0.0046 16.5 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF5427 PF10310.9 EFE41156.1 - 5.6 5.8 14.9 8.8 5.2 14.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Corona_S2 PF01601.16 EFE41158.1 - 3.2 6.1 17.1 4.5 5.6 17.1 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein MFS_1 PF07690.16 EFE41159.1 - 9.4e-21 74.1 49.8 9.4e-21 74.1 49.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE41159.1 - 2.8e-09 36.4 38.0 2.7e-05 23.2 2.0 4.2 2 2 2 4 4 4 4 Sugar (and other) transporter MFS_4 PF06779.14 EFE41159.1 - 1.4e-06 27.9 22.8 2e-06 27.4 22.8 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB CwfJ_C_1 PF04677.15 EFE41161.1 - 2.1e-25 89.0 0.0 4.4e-25 87.9 0.0 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EFE41161.1 - 7.2e-16 58.9 0.2 1.7e-15 57.7 0.2 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Toxin_38 PF14866.6 EFE41161.1 - 0.15 12.4 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 Potassium channel toxin DRIM PF07539.12 EFE41162.1 - 6.7e-188 625.9 0.3 6.7e-188 625.9 0.3 4.2 5 0 0 5 5 5 2 Down-regulated in metastasis HEAT PF02985.22 EFE41162.1 - 0.018 15.3 9.1 0.66 10.4 0.0 6.7 9 0 0 9 9 9 0 HEAT repeat zf-DNL PF05180.12 EFE41163.1 - 5e-27 93.6 0.4 5e-27 93.6 0.4 1.7 2 0 0 2 2 2 1 DNL zinc finger TFIIS_C PF01096.18 EFE41163.1 - 0.024 14.5 1.4 2.6 8.0 0.3 2.7 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-CSL PF05207.13 EFE41163.1 - 0.032 13.9 0.2 0.062 13.0 0.2 1.4 1 0 0 1 1 1 0 CSL zinc finger Elf1 PF05129.13 EFE41163.1 - 0.12 12.4 0.3 0.3 11.2 0.3 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 EFE41163.1 - 0.54 10.2 2.1 0.88 9.5 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Cullin PF00888.22 EFE41164.1 - 5.2e-200 666.2 7.7 5.2e-200 666.2 7.7 1.4 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EFE41164.1 - 2.5e-27 94.7 2.4 6.6e-27 93.3 0.8 2.7 3 0 0 3 3 3 1 Cullin protein neddylation domain DUF1737 PF08410.10 EFE41164.1 - 0.18 11.7 0.1 0.5 10.3 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) Kinesin_assoc PF16183.5 EFE41164.1 - 1.4 9.0 6.5 4.1 7.5 0.1 3.1 3 0 0 3 3 3 0 Kinesin-associated SLD5_C PF16922.5 EFE41165.1 - 7.9e-11 42.0 0.1 1.3e-10 41.3 0.1 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EFE41165.1 - 9.5e-06 26.0 0.2 1.4e-05 25.5 0.2 1.3 1 0 0 1 1 1 1 GINS complex protein Rhodanese PF00581.20 EFE41166.1 - 6.9e-14 52.3 0.0 1.5e-13 51.2 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain NUDE_C PF04880.13 EFE41166.1 - 8.5 6.8 19.8 5.4 7.5 6.4 2.6 1 1 1 2 2 2 0 NUDE protein, C-terminal conserved region Ferlin_C PF16165.5 EFE41168.1 - 7.2 6.5 6.4 9.9 6.1 6.4 1.3 1 0 0 1 1 1 0 Ferlin C-terminus Sec62 PF03839.16 EFE41169.1 - 4 6.9 5.5 2.5 7.6 0.7 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 Iso_dh PF00180.20 EFE41170.1 - 1e-82 278.1 0.0 1.2e-82 277.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DNA_pol_phi PF04931.13 EFE41171.1 - 1.3e-243 810.6 11.1 1.6e-243 810.3 11.1 1.1 1 0 0 1 1 1 1 DNA polymerase phi HEAT_EZ PF13513.6 EFE41171.1 - 0.046 14.2 1.8 1.2 9.7 0.0 3.9 3 2 2 5 5 5 0 HEAT-like repeat FANCI_S3 PF14677.6 EFE41171.1 - 0.48 10.1 5.1 7.6 6.2 0.1 3.3 3 1 0 3 3 3 0 FANCI solenoid 3 SDA1 PF05285.12 EFE41171.1 - 0.92 8.9 31.9 0.016 14.6 24.3 1.9 2 0 0 2 2 2 0 SDA1 TPT PF03151.16 EFE41172.1 - 1.2e-22 80.6 18.5 1.6e-22 80.2 18.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFE41172.1 - 7.2e-06 26.2 39.3 0.00029 21.0 17.7 2.4 2 0 0 2 2 2 2 EamA-like transporter family YihI PF04220.12 EFE41172.1 - 4.1 7.1 5.6 0.27 10.9 0.5 1.6 2 0 0 2 2 2 0 Der GTPase activator (YihI) AD PF09793.9 EFE41173.1 - 9.9e-26 89.7 0.0 2e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain Menin PF05053.13 EFE41173.1 - 1.2 7.4 3.1 1.5 7.1 3.1 1.1 1 0 0 1 1 1 0 Menin RRM_1 PF00076.22 EFE41174.1 - 5e-18 64.7 0.0 7.9e-18 64.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 EFE41174.1 - 0.028 14.4 27.8 0.043 13.8 27.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 EFE41174.1 - 9.8 4.6 7.9 14 4.1 7.9 1.2 1 0 0 1 1 1 0 Macoilin family Conotoxin PF02950.17 EFE41175.1 - 0.0048 17.9 0.1 0.0063 17.5 0.1 1.2 1 0 0 1 1 1 1 Conotoxin Phage_Gp23 PF10669.9 EFE41175.1 - 0.0058 17.0 1.2 0.0069 16.7 1.2 1.1 1 0 0 1 1 1 1 Protein gp23 (Bacteriophage A118) OPA3 PF07047.12 EFE41175.1 - 0.019 14.7 0.4 0.025 14.4 0.4 1.1 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) OSTbeta PF15048.6 EFE41175.1 - 0.033 14.3 0.3 0.038 14.1 0.3 1.1 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF5531 PF17671.1 EFE41175.1 - 0.051 13.5 0.5 0.059 13.3 0.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5531) Ctr PF04145.15 EFE41175.1 - 0.11 13.1 0.0 0.12 13.0 0.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Connexin PF00029.19 EFE41175.1 - 0.16 11.7 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 Connexin SHR3_chaperone PF08229.11 EFE41175.1 - 0.17 10.9 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 EphA2_TM PF14575.6 EFE41175.1 - 0.19 12.6 0.0 0.24 12.3 0.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain 6PGD PF00393.19 EFE41176.1 - 1.4e-127 425.0 0.0 1.7e-127 424.7 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EFE41176.1 - 7.6e-50 169.2 0.0 1.1e-49 168.6 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EFE41176.1 - 0.053 13.6 0.1 0.1 12.7 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_11 PF14833.6 EFE41176.1 - 0.14 12.4 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Esterase_phd PF10503.9 EFE41176.1 - 0.14 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase Peptidase_C15 PF01470.17 EFE41177.1 - 3.6e-13 50.1 0.0 1.2e-06 28.8 0.0 2.3 2 0 0 2 2 2 2 Pyroglutamyl peptidase AA_permease PF00324.21 EFE41179.1 - 4.3e-114 381.7 36.0 5.4e-114 381.4 36.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE41179.1 - 2.3e-28 99.2 38.4 2.8e-28 98.9 38.4 1.0 1 0 0 1 1 1 1 Amino acid permease HET PF06985.11 EFE41180.1 - 5.8e-27 94.8 0.3 3e-22 79.6 0.2 2.5 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) Ank_2 PF12796.7 EFE41180.1 - 6.3e-08 33.1 0.0 2.9e-07 31.0 0.0 2.0 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE41180.1 - 4e-07 30.4 0.0 2.9e-05 24.5 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE41180.1 - 6.7e-07 29.5 0.1 1.4e-06 28.5 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EFE41180.1 - 9e-05 22.7 0.0 0.8 10.3 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EFE41180.1 - 0.00013 22.2 0.0 0.15 12.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat AP_endonuc_2 PF01261.24 EFE41181.1 - 3.5e-23 82.2 0.0 5.6e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Mad3_BUB1_I PF08311.12 EFE41182.1 - 3.9e-44 149.6 0.1 7.9e-44 148.6 0.1 1.5 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 EFE41182.1 - 2.9e-16 59.4 0.0 1.6e-15 57.0 0.0 2.2 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.25 EFE41182.1 - 3.5e-12 46.3 0.0 7e-11 42.0 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41182.1 - 0.0005 19.4 0.0 0.0018 17.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Mad3_BUB1_I_2 PF17014.5 EFE41182.1 - 0.004 17.3 0.0 0.0093 16.1 0.0 1.6 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein APH PF01636.23 EFE41182.1 - 0.058 13.3 0.1 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF4379 PF14311.6 EFE41183.1 - 0.011 16.1 0.6 0.011 16.1 0.6 1.8 2 0 0 2 2 2 0 Probable Zinc-ribbon domain SDA1 PF05285.12 EFE41183.1 - 0.016 14.7 1.8 0.018 14.5 1.8 1.2 1 0 0 1 1 1 0 SDA1 Hexokinase_1 PF00349.21 EFE41185.1 - 1.1e-56 191.9 0.0 1.5e-56 191.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EFE41185.1 - 3.1e-45 154.5 0.0 4.5e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase ADH_zinc_N PF00107.26 EFE41186.1 - 4.6e-07 29.9 0.0 1e-06 28.8 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Fungal_trans PF04082.18 EFE41187.1 - 4e-11 42.5 0.2 6.9e-11 41.7 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE41187.1 - 2.3e-09 37.2 9.5 4.7e-09 36.2 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TRP PF06011.12 EFE41188.1 - 2.5e-166 553.7 28.6 3e-166 553.4 28.6 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EFE41188.1 - 1.4e-31 109.8 0.0 2.2e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 ML-like domain p450 PF00067.22 EFE41189.1 - 1e-27 97.0 0.0 1.3e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HsbA PF12296.8 EFE41190.1 - 1.6e-11 44.7 0.0 2.4e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A NPV_P10 PF05531.12 EFE41190.1 - 0.15 12.5 0.0 1.9 9.0 0.0 2.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF3602 PF12223.8 EFE41191.1 - 4.3e-19 68.9 4.3 6.6e-14 52.3 0.1 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) GTP1_OBG PF01018.22 EFE41191.1 - 0.12 11.9 4.2 16 5.1 0.3 3.1 1 1 2 3 3 3 0 GTP1/OBG Actin PF00022.19 EFE41192.1 - 8.7e-120 400.0 0.0 4.1e-119 397.8 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFE41192.1 - 0.14 11.0 0.0 6 5.6 0.0 2.6 3 0 0 3 3 3 0 MreB/Mbl protein Glyco_tran_28_C PF04101.16 EFE41193.1 - 0.0042 17.1 0.0 0.015 15.2 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain MRP-S28 PF10213.9 EFE41194.1 - 1.4e-40 138.6 0.0 2.1e-40 138.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein zf-CCCH PF00642.24 EFE41195.1 - 2.9 7.9 5.2 0.56 10.2 0.9 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF1772 PF08592.11 EFE41197.1 - 1.3e-30 106.5 1.1 1.8e-30 106.1 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Pex2_Pex12 PF04757.14 EFE41198.1 - 1.2e-35 123.2 0.9 1.6e-35 122.7 0.9 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 EFE41198.1 - 0.017 15.0 1.7 0.04 13.8 1.7 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFE41198.1 - 0.027 14.6 5.6 0.027 14.6 5.6 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EFE41198.1 - 0.035 14.1 5.5 0.17 11.9 5.5 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFE41198.1 - 0.4 10.6 5.4 0.76 9.7 1.6 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE41198.1 - 6.4 6.7 9.6 17 5.3 5.3 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) IBN_N PF03810.19 EFE41199.1 - 6.6e-13 48.4 0.0 3.1e-12 46.2 0.0 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFE41199.1 - 0.0004 20.5 1.4 0.013 15.6 0.0 3.5 4 0 0 4 4 4 1 Exportin 1-like protein DUF3385 PF11865.8 EFE41199.1 - 0.0048 16.8 0.4 0.019 14.9 0.4 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3385) Cellulase PF00150.18 EFE41200.1 - 3.4e-14 52.9 2.2 5.4e-14 52.3 0.1 2.4 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) GST_N_3 PF13417.6 EFE41201.1 - 1.5e-16 60.6 0.0 2.7e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE41201.1 - 1.2e-13 51.2 0.0 2e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFE41201.1 - 1.3e-06 28.3 0.2 3e-06 27.1 0.2 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFE41201.1 - 2.1e-05 24.8 0.1 0.00022 21.5 0.1 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFE41201.1 - 0.0093 16.2 0.0 0.025 14.8 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain PBP1_TM PF14812.6 EFE41202.1 - 4.2 7.8 7.8 4.8 7.6 1.8 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SR-25 PF10500.9 EFE41203.1 - 0.12 11.9 9.6 0.12 12.0 9.6 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_S49_N PF08496.10 EFE41203.1 - 1.4 9.0 7.9 1.4 9.0 7.9 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Coilin_N PF15862.5 EFE41203.1 - 2.9 7.7 9.3 3 7.6 9.3 1.0 1 0 0 1 1 1 0 Coilin N-terminus GPI-anchored PF10342.9 EFE41204.1 - 9.9e-23 80.7 1.1 1.6e-22 80.1 0.1 1.8 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Glyco_transf_90 PF05686.12 EFE41205.1 - 1.2e-37 129.7 4.6 3.4e-37 128.3 4.6 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 EFE41205.1 - 0.014 15.8 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF16 PF01519.16 EFE41206.1 - 0.0021 18.5 5.0 0.0047 17.4 5.0 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF16 Prefoldin_2 PF01920.20 EFE41206.1 - 2.7 8.0 9.3 6.2 6.8 0.6 2.5 1 1 1 2 2 2 0 Prefoldin subunit PKcGMP_CC PF16808.5 EFE41206.1 - 8.4 6.3 7.4 9.8 6.1 4.9 2.4 1 1 1 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Gly_transf_sug PF04488.15 EFE41207.1 - 2.4e-10 40.9 0.0 6e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EFE41207.1 - 0.047 13.1 0.0 0.047 13.1 0.0 2.0 2 0 0 2 2 2 0 Capsular polysaccharide synthesis protein Borrelia_P83 PF05262.11 EFE41207.1 - 0.069 11.6 12.9 0.079 11.4 12.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein RR_TM4-6 PF06459.12 EFE41207.1 - 0.18 11.6 14.6 0.3 10.9 14.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 EFE41207.1 - 0.28 9.9 7.5 0.35 9.6 7.5 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DDHD PF02862.17 EFE41207.1 - 1.4 9.0 6.5 2.2 8.4 6.5 1.4 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 EFE41207.1 - 7.7 6.5 7.0 15 5.6 7.0 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1168 PF06658.12 EFE41208.1 - 0.0072 16.2 10.1 0.0091 15.8 10.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) SH3_1 PF00018.28 EFE41209.1 - 3e-09 36.4 0.1 5.2e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE41209.1 - 4.5e-07 29.6 0.0 1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFE41209.1 - 6.6e-06 25.7 0.0 1.3e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 EFE41209.1 - 0.089 12.9 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 SH3 domain YhhN PF07947.14 EFE41209.1 - 0.13 11.9 8.3 0.18 11.4 8.3 1.1 1 0 0 1 1 1 0 YhhN family MDFI PF15316.6 EFE41210.1 - 0.92 9.6 2.4 1.2 9.2 2.4 1.2 1 0 0 1 1 1 0 MyoD family inhibitor Dynactin_p22 PF07426.11 EFE41211.1 - 2.9e-06 27.2 0.1 4.5e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Dynactin subunit p22 UBA_4 PF14555.6 EFE41211.1 - 0.00081 19.2 0.3 0.0017 18.2 0.3 1.5 1 0 0 1 1 1 1 UBA-like domain ZapB PF06005.12 EFE41211.1 - 0.75 10.3 8.1 23 5.5 1.7 3.7 3 0 0 3 3 3 0 Cell division protein ZapB Matrilin_ccoil PF10393.9 EFE41211.1 - 0.85 9.5 4.0 2.1 8.2 2.2 2.4 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin SET PF00856.28 EFE41212.1 - 5.8e-12 46.3 0.0 1.2e-11 45.3 0.0 1.6 1 0 0 1 1 1 1 SET domain AMP-binding PF00501.28 EFE41213.1 - 4.8e-73 246.2 0.0 6.7e-73 245.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE41213.1 - 3e-13 50.6 0.2 8.8e-13 49.1 0.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AIF_C PF14721.6 EFE41214.1 - 0.22 11.9 0.7 0.34 11.3 0.7 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CDC45 PF02724.14 EFE41214.1 - 0.57 8.4 9.0 0.66 8.2 9.0 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 EFE41214.1 - 1.7 8.4 9.3 2 8.2 9.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.13 EFE41214.1 - 3.3 6.4 5.8 3.3 6.4 5.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 EFE41215.1 - 2 8.2 16.7 2.5 7.9 16.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EFE41215.1 - 8 4.6 17.2 9.3 4.4 17.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 EFE41216.1 - 9.1e-52 176.0 0.0 1.2e-51 175.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41216.1 - 1e-25 90.5 0.2 8.6e-25 87.5 0.2 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE41216.1 - 0.0029 17.0 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFE41216.1 - 0.14 11.0 1.0 0.21 10.3 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 EFE41216.1 - 0.16 11.6 0.2 0.67 9.5 0.1 1.9 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFE41216.1 - 0.21 10.9 0.0 0.37 10.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TFIIA PF03153.13 EFE41216.1 - 2.7 7.9 15.5 3.5 7.5 15.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Bot1p PF12298.8 EFE41217.1 - 1.6e-20 74.0 0.2 1.6e-20 74.0 0.2 1.9 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein Bot1p PF12298.8 EFE41218.1 - 3.8e-26 92.3 1.4 4e-26 92.2 0.3 1.6 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein FoP_duplication PF13865.6 EFE41220.1 - 2.8e-08 34.2 10.0 2.8e-08 34.2 10.0 2.3 2 0 0 2 2 2 2 C-terminal duplication domain of Friend of PRMT1 WD40 PF00400.32 EFE41221.1 - 1.9e-08 34.8 0.5 0.015 16.1 0.3 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE41221.1 - 0.012 15.8 0.1 0.94 9.8 0.0 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Me-amine-dh_H PF06433.11 EFE41221.1 - 0.044 12.7 0.0 0.98 8.2 0.0 2.1 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) PUL PF08324.11 EFE41222.1 - 2.2e-71 240.3 0.2 3e-71 239.9 0.2 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 EFE41222.1 - 3.7e-44 149.6 0.1 8e-44 148.5 0.1 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EFE41222.1 - 3.5e-31 106.7 17.4 6.2e-07 30.0 0.0 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat RRM_1 PF00076.22 EFE41224.1 - 3.1e-17 62.1 0.0 2.2e-13 49.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spt20 PF12090.8 EFE41224.1 - 0.0013 18.3 7.6 0.0019 17.9 7.6 1.2 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 EFE41224.1 - 0.0025 17.9 7.5 0.004 17.2 7.5 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 EFE41224.1 - 0.0055 16.7 4.0 0.0098 15.9 4.0 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) RRM_occluded PF16842.5 EFE41224.1 - 0.021 14.7 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif TERB2 PF15101.6 EFE41224.1 - 0.077 13.1 1.7 0.13 12.4 1.7 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Dynactin_p62 PF05502.13 EFE41224.1 - 0.49 9.1 3.3 0.65 8.7 2.0 1.7 2 0 0 2 2 2 0 Dynactin p62 family DUF4834 PF16118.5 EFE41224.1 - 1.3 10.0 6.0 3.5 8.7 6.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 EFE41225.1 - 5.6 5.6 5.1 5 5.8 5.1 1.0 1 0 0 1 1 1 0 Presenilin CH PF00307.31 EFE41226.1 - 9.1e-30 103.1 0.0 8.8e-24 83.8 0.0 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EFE41226.1 - 4.1e-20 71.6 1.1 1.3e-14 54.0 0.2 2.8 2 0 0 2 2 2 2 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 EFE41226.1 - 1.2e-07 31.5 0.0 3.7e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 CAMSAP CH domain EF-hand_6 PF13405.6 EFE41226.1 - 0.0014 18.4 0.0 0.0069 16.2 0.0 2.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 EFE41226.1 - 0.0054 16.6 0.2 0.04 13.8 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair Spectrin PF00435.21 EFE41226.1 - 0.0083 16.6 5.4 0.61 10.6 0.0 2.8 1 1 0 2 2 2 1 Spectrin repeat EF-hand_1 PF00036.32 EFE41226.1 - 0.014 14.9 0.0 0.21 11.2 0.0 2.7 2 0 0 2 2 2 0 EF hand SKA1 PF07160.12 EFE41226.1 - 0.09 12.6 1.5 0.16 11.8 0.9 1.6 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 EF-hand_7 PF13499.6 EFE41226.1 - 0.17 12.3 2.5 0.81 10.2 0.2 2.9 2 0 0 2 2 2 0 EF-hand domain pair zf-RRPl_C4 PF17026.5 EFE41226.1 - 0.17 12.0 0.0 0.43 10.7 0.0 1.6 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type FliG_N PF14842.6 EFE41226.1 - 0.24 12.0 2.8 3.3 8.3 0.1 3.1 2 1 1 3 3 3 0 FliG N-terminal domain Hom_end_hint PF05203.16 EFE41226.1 - 0.4 10.6 1.4 1 9.3 1.1 1.8 1 1 1 2 2 2 0 Hom_end-associated Hint Baculo_PEP_C PF04513.12 EFE41226.1 - 1.8 8.6 3.8 1.8 8.6 0.6 2.5 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HTH_33 PF13592.6 EFE41227.1 - 0.025 14.2 2.6 0.27 10.9 0.2 2.1 2 0 0 2 2 2 0 Winged helix-turn helix G-alpha PF00503.20 EFE41228.1 - 2e-116 389.1 2.4 6e-116 387.5 2.4 1.7 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFE41228.1 - 3.3e-11 42.9 1.7 4.4e-10 39.3 0.1 2.7 2 1 0 2 2 2 1 ADP-ribosylation factor family zf-CHC2 PF01807.20 EFE41228.1 - 9.6e-05 22.1 0.0 0.00033 20.4 0.0 1.8 2 0 0 2 2 2 1 CHC2 zinc finger Use1 PF09753.9 EFE41229.1 - 4.1e-10 39.8 10.3 2.2e-08 34.1 10.3 2.2 1 1 0 1 1 1 1 Membrane fusion protein Use1 DUF4683 PF15735.5 EFE41229.1 - 0.041 13.5 4.4 0.068 12.8 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4683) DUF5538 PF17692.1 EFE41229.1 - 0.15 12.1 2.3 0.35 10.9 2.3 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5538) HR1 PF02185.16 EFE41229.1 - 1.8 8.8 8.0 0.13 12.4 2.1 2.4 3 0 0 3 3 3 0 Hr1 repeat Acetyltransf_1 PF00583.25 EFE41230.1 - 5.8e-05 23.3 0.0 0.00015 22.0 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE41230.1 - 0.00014 21.7 0.0 0.0054 16.7 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE41230.1 - 0.02 15.3 0.0 0.038 14.4 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain RXT2_N PF08595.11 EFE41232.1 - 0.012 15.6 7.5 0.014 15.4 7.5 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal Sporozoite_P67 PF05642.11 EFE41232.1 - 0.044 11.9 3.6 0.039 12.0 3.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pox_Ag35 PF03286.14 EFE41232.1 - 0.089 12.6 4.8 0.098 12.4 4.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Cwf_Cwc_15 PF04889.12 EFE41232.1 - 0.17 11.6 12.6 0.18 11.5 12.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nucleo_P87 PF07267.11 EFE41232.1 - 0.81 8.5 5.9 0.91 8.3 5.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF2457 PF10446.9 EFE41232.1 - 0.89 8.6 16.4 0.98 8.5 16.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) FAM176 PF14851.6 EFE41232.1 - 1 9.0 7.8 1.4 8.6 7.8 1.3 1 0 0 1 1 1 0 FAM176 family UPF0560 PF10577.9 EFE41232.1 - 2.4 6.5 6.4 2.8 6.3 6.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 AMP-binding PF00501.28 EFE41233.1 - 1.8e-22 79.5 0.7 2.7e-22 79.0 0.7 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE41233.1 - 5.5e-08 33.7 0.0 2.1e-07 31.8 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 EFE41234.1 - 3.9e-57 193.8 0.0 5.1e-57 193.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Nup188_C PF18378.1 EFE41235.1 - 2.2e-138 461.1 0.0 3.6e-138 460.4 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup188 PF10487.9 EFE41235.1 - 7e-81 272.5 0.0 1.1e-79 268.6 0.0 2.3 1 1 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 IGPS PF00218.21 EFE41236.1 - 1.6e-94 315.8 0.0 4.1e-94 314.5 0.0 1.7 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 EFE41236.1 - 3.5e-52 177.0 0.1 1.5e-47 161.9 0.0 2.3 2 0 0 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 EFE41236.1 - 1e-47 162.4 0.0 2.2e-47 161.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFE41236.1 - 0.00047 20.0 0.3 0.0028 17.4 0.3 2.1 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 EFE41236.1 - 0.003 17.4 0.4 0.15 11.9 0.0 2.5 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 EFE41236.1 - 0.019 14.5 0.1 0.12 11.8 0.0 2.1 2 0 0 2 2 2 0 Histidine biosynthesis protein BRCT_2 PF16589.5 EFE41237.1 - 4.3e-05 23.9 0.0 7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EFE41237.1 - 0.00011 22.1 0.0 0.0002 21.2 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EFE41237.1 - 0.006 16.9 0.1 0.011 16.1 0.1 1.5 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF4085 PF13315.6 EFE41237.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) AAA_12 PF13087.6 EFE41238.1 - 4.6e-58 196.1 0.0 7.5e-58 195.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain UPF1_Zn_bind PF09416.10 EFE41238.1 - 9.1e-57 191.3 0.7 4.4e-55 185.8 0.0 2.4 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_11 PF13086.6 EFE41238.1 - 4.3e-52 177.5 5.3 4.7e-30 105.2 0.3 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 EFE41238.1 - 1.9e-33 114.6 0.0 3.8e-33 113.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EFE41238.1 - 3.8e-12 46.3 0.2 3.1e-11 43.4 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFE41238.1 - 5.5e-10 39.8 0.1 2.7e-09 37.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EFE41238.1 - 3.5e-06 27.1 0.0 6.8e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 EFE41238.1 - 0.00017 21.5 0.0 0.00034 20.5 0.0 1.5 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.18 EFE41238.1 - 0.00047 20.0 0.1 1.2 8.8 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 EFE41238.1 - 0.002 17.5 0.6 0.034 13.4 0.1 2.4 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 EFE41238.1 - 0.022 14.3 0.1 0.3 10.6 0.0 2.4 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 EFE41238.1 - 0.026 13.7 0.0 5.8 6.0 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase DEAD PF00270.29 EFE41238.1 - 0.026 14.3 0.3 0.052 13.3 0.3 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 EFE41238.1 - 0.028 14.7 0.0 0.083 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EFE41238.1 - 0.045 13.2 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein DUF4123 PF13503.6 EFE41238.1 - 0.077 13.4 0.7 0.94 9.9 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4123) TFIIF_alpha PF05793.12 EFE41238.1 - 0.083 11.5 2.3 0.14 10.7 2.3 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA_16 PF13191.6 EFE41238.1 - 0.13 12.6 0.1 0.29 11.5 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.7 EFE41238.1 - 0.14 11.1 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain SRP54 PF00448.22 EFE41238.1 - 0.16 11.6 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATPase PF06745.13 EFE41238.1 - 0.21 10.9 0.0 0.39 10.0 0.0 1.5 1 0 0 1 1 1 0 KaiC PBP1_TM PF14812.6 EFE41238.1 - 1.2 9.5 4.7 3.2 8.2 4.7 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Brix PF04427.18 EFE41239.1 - 4.9e-32 111.6 0.0 6.2e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 Brix domain AhpC-TSA_2 PF13911.6 EFE41240.1 - 2.5e-12 46.9 0.0 4.5e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EFE41240.1 - 0.016 15.1 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family PI-PLC-X PF00388.19 EFE41241.1 - 2.8e-58 195.6 0.0 6.7e-58 194.4 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EFE41241.1 - 7.5e-43 145.5 0.1 1.5e-42 144.6 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EFE41241.1 - 4.7e-05 23.6 0.0 0.00033 20.9 0.0 2.3 1 1 0 1 1 1 1 C2 domain EF-hand_like PF09279.11 EFE41241.1 - 0.002 18.5 0.9 0.0068 16.9 0.9 1.9 1 1 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_8 PF13833.6 EFE41241.1 - 0.0028 17.5 0.0 0.0057 16.5 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 EFE41241.1 - 0.015 15.7 0.0 0.071 13.6 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 EFE41241.1 - 0.024 14.2 0.2 0.061 12.9 0.0 1.8 2 0 0 2 2 2 0 EF hand GDPD PF03009.17 EFE41241.1 - 0.16 11.6 0.0 0.4 10.4 0.0 1.6 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family LPMO_10 PF03067.15 EFE41242.1 - 0.0038 17.9 0.1 0.01 16.5 0.1 1.7 1 1 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Mo-co_dimer PF03404.16 EFE41244.1 - 1.7e-58 196.6 0.6 3e-58 195.7 0.6 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.19 EFE41244.1 - 3.7e-36 124.3 0.0 7.4e-36 123.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain NAD_binding_1 PF00175.21 EFE41244.1 - 1.8e-27 96.2 0.0 4.1e-27 95.0 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 EFE41244.1 - 4.1e-19 68.5 0.0 1e-18 67.2 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_6 PF00970.24 EFE41244.1 - 2.3e-17 63.2 0.0 4.2e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EFE41244.1 - 9.3e-05 22.6 0.1 0.01 15.9 0.0 2.4 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Sec5 PF15469.6 EFE41245.1 - 2.9e-36 125.1 0.0 7.6e-36 123.7 0.0 1.8 1 0 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.11 EFE41245.1 - 2.1e-05 24.5 0.9 8.1e-05 22.6 0.9 2.1 1 0 0 1 1 1 1 Vps51/Vps67 GTP-bdg_M PF16360.5 EFE41245.1 - 0.0013 19.2 0.7 0.1 13.2 0.2 3.6 3 0 0 3 3 3 1 GTP-binding GTPase Middle Region COG2 PF06148.11 EFE41245.1 - 0.081 13.0 0.3 0.32 11.1 0.3 2.0 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF802 PF05650.11 EFE41245.1 - 0.72 10.4 4.0 0.34 11.4 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF802) Iso_dh PF00180.20 EFE41246.1 - 1.8e-101 339.8 0.0 2.2e-101 339.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phage_30_3 PF08010.11 EFE41246.1 - 0.0079 16.0 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 Bacteriophage protein GP30.3 GCP_C_terminal PF04130.13 EFE41247.1 - 3e-67 227.3 0.0 4.2e-67 226.8 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EFE41247.1 - 2.3e-32 112.8 0.0 1.1e-31 110.6 0.0 2.1 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal rRNA_processing PF08524.11 EFE41248.1 - 0.089 12.8 25.5 23 5.0 25.3 2.4 1 1 0 1 1 1 0 rRNA processing DUF4210 PF13915.6 EFE41249.1 - 2.9e-33 114.3 0.1 1.6e-32 111.9 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 EFE41249.1 - 9.7e-22 76.9 0.2 2.4e-21 75.6 0.2 1.7 1 0 0 1 1 1 1 Chromosome segregation during meiosis CAP_N PF01213.19 EFE41250.1 - 1.6e-111 372.8 0.0 2.6e-111 372.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EFE41250.1 - 3e-54 182.9 0.9 4.2e-54 182.4 0.9 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EFE41250.1 - 0.1 12.3 3.1 1.8 8.3 3.0 2.2 1 1 1 2 2 2 0 Tubulin binding cofactor C Ribosomal_60s PF00428.19 EFE41250.1 - 4.3 8.0 8.8 0.3 11.7 1.4 2.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein PfkB PF00294.24 EFE41251.1 - 1.9e-11 43.8 0.0 2.9e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Ribonucleas_3_3 PF14622.6 EFE41252.1 - 8.5e-07 29.2 0.0 0.0042 17.3 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.26 EFE41252.1 - 5.1e-06 27.1 0.0 9.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 EFE41252.1 - 0.00013 22.5 0.0 0.00025 21.6 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain BSP PF04450.12 EFE41253.1 - 2.1e-63 213.8 0.0 2.6e-63 213.6 0.0 1.0 1 0 0 1 1 1 1 Peptidase of plants and bacteria CLASP_N PF12348.8 EFE41254.1 - 1e-149 496.3 4.1 1.9e-92 309.0 0.0 3.0 3 1 0 3 3 3 2 CLASP N terminal HEAT PF02985.22 EFE41254.1 - 1.8e-05 24.6 0.6 5.3 7.6 0.0 6.3 7 0 0 7 7 7 2 HEAT repeat Cnd1 PF12717.7 EFE41254.1 - 4.1e-05 23.7 0.1 3.5 7.7 0.0 4.4 4 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Acetyltransf_8 PF13523.6 EFE41255.1 - 1e-46 158.2 0.9 1.5e-46 157.7 0.9 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ABC_membrane PF00664.23 EFE41256.1 - 3.4e-90 302.4 32.4 1.8e-46 159.0 10.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE41256.1 - 4.3e-66 221.6 0.0 6.7e-32 110.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFE41256.1 - 5.2e-16 58.8 2.9 2.3e-05 24.0 0.1 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EFE41256.1 - 4.2e-10 39.0 0.5 0.0011 17.9 0.0 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 EFE41256.1 - 5e-09 35.8 0.7 0.002 17.8 0.0 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFE41256.1 - 5.1e-08 33.5 1.0 0.0012 19.2 0.2 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFE41256.1 - 1.2e-07 32.1 1.5 0.099 12.9 0.0 4.0 3 1 0 4 4 3 2 AAA domain DUF87 PF01935.17 EFE41256.1 - 1.7e-07 31.6 0.1 0.0013 18.9 0.0 2.8 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_15 PF13175.6 EFE41256.1 - 1.3e-05 25.1 0.0 0.058 13.1 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 EFE41256.1 - 6.5e-05 22.7 1.7 0.14 11.9 0.0 3.7 3 1 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EFE41256.1 - 7.6e-05 22.7 0.0 0.56 10.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase DUF3987 PF13148.6 EFE41256.1 - 0.00023 20.3 0.0 0.16 10.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3987) AAA_21 PF13304.6 EFE41256.1 - 0.00049 20.0 1.9 4.4 7.0 0.0 3.8 4 0 0 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EFE41256.1 - 0.00072 20.1 0.0 0.42 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EFE41256.1 - 0.00092 19.8 0.7 2.3 8.7 0.0 2.8 3 0 0 3 3 2 2 AAA domain Zeta_toxin PF06414.12 EFE41256.1 - 0.0014 17.9 0.1 0.66 9.2 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 EFE41256.1 - 0.0022 18.1 0.1 1.7 8.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EFE41256.1 - 0.0027 17.0 0.0 1.1 8.3 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 EFE41256.1 - 0.0035 16.7 0.0 0.046 13.1 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family SRP54 PF00448.22 EFE41256.1 - 0.0061 16.2 0.1 0.8 9.3 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_5 PF07728.14 EFE41256.1 - 0.0067 16.4 0.1 6.7 6.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EFE41256.1 - 0.011 15.3 0.0 3 7.4 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_28 PF13521.6 EFE41256.1 - 0.018 15.3 0.2 3.8 7.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFE41256.1 - 0.019 14.7 0.1 7.3 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EFE41256.1 - 0.035 13.0 0.1 1.3 7.9 0.0 2.8 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain SbcCD_C PF13558.6 EFE41256.1 - 0.047 13.9 4.8 4.8 7.5 0.3 3.8 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PRK PF00485.18 EFE41256.1 - 0.069 12.9 0.7 13 5.5 0.1 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Rad17 PF03215.15 EFE41256.1 - 0.071 13.0 0.0 2.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_7 PF12775.7 EFE41256.1 - 0.072 12.6 0.0 13 5.2 0.0 2.9 2 0 0 2 2 2 0 P-loop containing dynein motor region MTH865 PF07747.11 EFE41256.1 - 0.078 12.8 0.0 6.6 6.6 0.0 2.5 2 0 0 2 2 2 0 MTH865-like family DUF779 PF05610.11 EFE41256.1 - 0.12 12.7 0.0 5.7 7.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF779) AAA_17 PF13207.6 EFE41256.1 - 0.12 12.8 0.1 26 5.3 0.0 3.0 2 0 0 2 2 2 0 AAA domain FERM_N PF09379.10 EFE41256.1 - 0.16 11.9 0.1 0.55 10.2 0.1 1.9 1 0 0 1 1 1 0 FERM N-terminal domain ATP_bind_1 PF03029.17 EFE41256.1 - 0.26 11.0 1.5 12 5.6 0.0 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein COX5A PF02284.16 EFE41257.1 - 4.8e-31 106.8 0.4 8.7e-30 102.8 0.1 2.1 2 0 0 2 2 2 2 Cytochrome c oxidase subunit Va RR_TM4-6 PF06459.12 EFE41258.1 - 0.15 11.9 4.1 0.17 11.7 4.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCDC71L PF15374.6 EFE41258.1 - 0.22 10.8 5.5 0.23 10.7 5.5 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Connexin PF00029.19 EFE41258.1 - 0.24 11.1 2.0 0.25 11.0 2.0 1.0 1 0 0 1 1 1 0 Connexin ELO PF01151.18 EFE41259.1 - 8.5e-63 212.2 19.8 1e-62 211.9 19.8 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family AA_permease_2 PF13520.6 EFE41262.1 - 2.4e-23 82.7 22.4 3.1e-23 82.3 22.4 1.1 1 0 0 1 1 1 1 Amino acid permease adh_short_C2 PF13561.6 EFE41263.1 - 1.4e-62 211.3 0.0 1.9e-62 210.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE41263.1 - 1.1e-51 175.0 0.5 1.4e-51 174.7 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE41263.1 - 2.5e-05 24.2 0.6 6.3e-05 23.0 0.6 1.6 1 1 0 1 1 1 1 KR domain HI0933_like PF03486.14 EFE41263.1 - 0.046 12.4 0.2 0.062 12.0 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Epimerase PF01370.21 EFE41263.1 - 0.066 12.7 0.1 0.11 12.0 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1996 PF09362.10 EFE41264.1 - 2.1e-84 283.2 0.0 3.5e-84 282.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) AdoMet_MTase PF07757.13 EFE41264.1 - 0.017 15.5 0.0 0.031 14.6 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase DUF4732 PF15876.5 EFE41266.1 - 0.082 13.0 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4732) Clat_adaptor_s PF01217.20 EFE41267.1 - 5.5e-42 143.1 0.0 9e-42 142.4 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MMR_HSR1 PF01926.23 EFE41268.1 - 3.1e-15 56.3 0.0 5.8e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFE41268.1 - 9.2e-06 25.8 0.1 0.00031 20.9 0.1 2.2 1 1 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 EFE41268.1 - 2.4e-05 24.0 0.1 0.013 15.0 0.0 2.7 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EFE41268.1 - 2.5e-05 23.7 0.0 4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EFE41268.1 - 0.00017 21.5 0.5 0.001 19.0 0.2 2.1 2 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EFE41268.1 - 0.0019 17.7 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 EFE41268.1 - 0.0041 16.4 0.0 0.0065 15.8 0.0 1.4 1 0 0 1 1 1 1 Septin SRPRB PF09439.10 EFE41268.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EFE41268.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EFE41268.1 - 0.15 11.5 0.0 0.4 10.1 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein WD40 PF00400.32 EFE41269.1 - 1.1e-40 136.9 17.2 3.3e-06 27.7 0.2 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 EFE41269.1 - 2.3e-10 40.2 0.1 5.1e-10 39.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE41269.1 - 3.1e-10 39.7 0.2 5.9e-10 38.8 0.2 1.4 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EFE41269.1 - 3.2e-05 24.2 1.1 8.1 6.8 0.0 4.6 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE41269.1 - 6.8e-05 21.7 3.4 5.1 5.6 0.2 5.3 4 2 2 6 6 6 3 Nucleoporin Nup120/160 F-box_4 PF15966.5 EFE41269.1 - 0.0019 18.0 0.0 0.0056 16.6 0.0 1.8 1 0 0 1 1 1 1 F-box AcylCoA_DH_N PF12418.8 EFE41269.1 - 0.04 13.9 0.2 0.11 12.5 0.2 1.8 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase N terminal FliG_C PF01706.16 EFE41269.1 - 0.092 13.0 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 FliG C-terminal domain HORMA PF02301.18 EFE41270.1 - 8.7e-57 192.1 0.0 1.9e-56 191.0 0.0 1.6 1 0 0 1 1 1 1 HORMA domain Nuc_sug_transp PF04142.15 EFE41274.1 - 8.4e-82 274.8 6.8 1.1e-81 274.4 6.8 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EFE41274.1 - 0.0026 17.9 8.5 0.0026 17.9 8.5 2.7 2 2 0 2 2 2 1 EamA-like transporter family DUF4160 PF13711.6 EFE41274.1 - 0.086 13.2 0.0 0.46 10.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) DEAD PF00270.29 EFE41275.1 - 7.7e-28 97.4 0.1 1.1e-27 96.9 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFE41275.1 - 1.1e-14 54.8 0.0 1.7e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFE41275.1 - 0.00015 22.0 0.0 0.00035 20.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFE41275.1 - 0.00018 21.8 0.1 0.00044 20.6 0.1 1.5 1 1 0 1 1 1 1 AAA domain SWI2_SNF2 PF18766.1 EFE41275.1 - 0.00027 20.7 0.1 0.00045 19.9 0.1 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_30 PF13604.6 EFE41275.1 - 0.00039 20.2 0.0 0.00085 19.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFE41275.1 - 0.0023 18.4 0.1 0.0051 17.2 0.1 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EFE41275.1 - 0.027 13.5 0.0 0.046 12.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Flavi_DEAD PF07652.14 EFE41275.1 - 0.039 13.9 0.0 0.24 11.4 0.0 2.0 1 1 0 1 1 1 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 EFE41275.1 - 0.064 13.1 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Helicase TniB PF05621.11 EFE41275.1 - 0.068 12.6 0.1 3.9 6.8 0.1 2.3 2 0 0 2 2 2 0 Bacterial TniB protein Sec63 PF02889.16 EFE41276.1 - 5.4e-31 107.7 0.0 6.8e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.31 EFE41276.1 - 6.5e-08 32.9 0.0 1.6e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.6 EFE41276.1 - 0.058 14.0 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain LRR_4 PF12799.7 EFE41278.1 - 0.00057 20.2 1.5 0.0032 17.8 0.7 2.6 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFE41278.1 - 0.034 14.2 4.1 54 4.2 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 EFE41278.1 - 0.12 12.2 0.7 1.3 8.8 0.4 2.6 2 1 0 2 2 2 0 Leucine rich repeat GlcNAc PF11397.8 EFE41278.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase (GlcNAc) Acid_PPase PF12689.7 EFE41279.1 - 1.1e-69 233.7 0.0 1.2e-69 233.4 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase HAD PF12710.7 EFE41279.1 - 0.18 12.2 0.8 5 7.5 0.0 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase TPR_MLP1_2 PF07926.12 EFE41280.1 - 2.4e-37 127.9 31.1 2.4e-37 127.9 31.1 17.9 6 6 9 17 17 17 7 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 EFE41280.1 - 0.0074 16.3 5.7 0.0074 16.3 5.7 13.3 7 6 8 16 16 16 3 Baculovirus polyhedron envelope protein, PEP, C terminus Wzy_C_2 PF11846.8 EFE41280.1 - 0.028 14.3 0.5 0.15 12.0 0.5 2.3 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal Cbl_N PF02262.16 EFE41280.1 - 0.55 10.2 7.3 0.92 9.5 0.2 4.6 3 0 0 3 3 3 0 CBL proto-oncogene N-terminal domain 1 Fez1 PF06818.15 EFE41280.1 - 4.3 7.8 242.1 0.012 16.0 19.7 12.6 2 2 10 12 12 12 0 Fez1 TFIIE_beta PF02186.15 EFE41281.1 - 1e-22 80.1 0.1 1.2e-21 76.8 0.0 2.5 2 1 0 2 2 2 1 TFIIE beta subunit core domain TFA2_Winged_2 PF18121.1 EFE41281.1 - 4.4e-22 77.5 1.5 6.9e-22 76.9 0.3 2.0 3 0 0 3 3 3 1 TFA2 Winged helix domain 2 DHBP_synthase PF00926.19 EFE41282.1 - 6.8e-78 260.6 0.0 8.6e-78 260.3 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase F-box-like PF12937.7 EFE41283.1 - 4.8e-10 39.2 1.1 1e-09 38.1 1.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE41283.1 - 3.6e-09 36.3 1.0 2e-08 33.9 0.3 2.3 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 EFE41283.1 - 0.0061 16.4 0.1 0.016 15.0 0.1 1.7 1 0 0 1 1 1 1 F-box Pkinase PF00069.25 EFE41284.1 - 2.2e-52 178.1 0.0 7.7e-52 176.2 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41284.1 - 1.7e-21 76.7 0.0 2.3e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE41284.1 - 6.8e-10 38.7 0.0 9.4e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFE41284.1 - 0.0024 17.3 0.0 0.027 13.8 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family UQ_con PF00179.26 EFE41285.1 - 2.8e-41 140.4 0.0 3.8e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFE41285.1 - 0.00018 21.8 0.0 0.00022 21.5 0.0 1.3 1 1 0 1 1 1 1 RWD domain UEV PF05743.13 EFE41285.1 - 0.013 15.3 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 UEV domain Prok-E2_B PF14461.6 EFE41285.1 - 0.035 13.8 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Nucleos_tra2_C PF07662.13 EFE41286.1 - 8e-73 244.7 1.0 8e-73 244.7 1.0 3.4 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EFE41286.1 - 7.4e-23 80.9 4.3 7.4e-23 80.9 4.3 3.0 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Prenyltransf PF01255.19 EFE41288.1 - 6.5e-58 195.9 0.1 1.5e-56 191.5 0.1 2.0 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DUF2600 PF10776.9 EFE41288.1 - 0.035 13.0 0.0 0.052 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) UbiA PF01040.18 EFE41289.1 - 2.8e-11 43.2 5.6 2.8e-11 43.2 5.6 1.8 1 1 0 1 1 1 1 UbiA prenyltransferase family Glyco_transf_20 PF00982.21 EFE41290.1 - 2e-181 603.8 0.1 1.2e-97 327.6 0.0 2.0 1 1 1 2 2 2 2 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 EFE41290.1 - 0.014 15.1 0.1 0.04 13.6 0.1 1.8 1 1 1 2 2 2 0 Starch synthase catalytic domain BLACT_WH PF17778.1 EFE41291.1 - 7.8e-19 67.4 0.1 1.3e-18 66.7 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Aconitase PF00330.20 EFE41292.1 - 2.9e-148 494.7 0.0 3.6e-148 494.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFE41292.1 - 2.6e-43 147.5 0.0 4.5e-43 146.7 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Rad54_N PF08658.10 EFE41293.1 - 1e-58 198.5 0.2 1.2e-58 198.3 0.2 1.0 1 0 0 1 1 1 1 Rad54 N terminal EMG1 PF03587.14 EFE41294.1 - 2.6e-79 265.4 0.0 3e-79 265.2 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase AIM3 PF17096.5 EFE41295.1 - 1.1 10.2 26.4 0.085 13.8 4.9 3.9 2 1 1 3 3 3 0 Altered inheritance of mitochondria protein 3 UQ_con PF00179.26 EFE41296.1 - 1.9e-32 111.9 1.0 2e-31 108.5 1.0 1.9 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFE41296.1 - 0.05 13.9 0.3 0.067 13.5 0.3 1.4 1 1 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EFE41296.1 - 0.062 13.0 0.0 0.091 12.5 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Acyl-CoA_dh_N PF02771.16 EFE41297.1 - 5.7e-26 91.4 0.1 1.1e-25 90.5 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EFE41297.1 - 3.2e-23 82.6 0.1 5.5e-23 81.8 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFE41297.1 - 3.7e-15 55.9 0.0 7.2e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFE41297.1 - 7.5e-07 29.5 0.5 7.5e-07 29.5 0.5 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Metal_CEHH PF14455.6 EFE41297.1 - 0.018 14.7 0.3 0.043 13.4 0.1 1.7 2 0 0 2 2 2 0 Predicted metal binding domain Acetyltransf_13 PF13880.6 EFE41299.1 - 2.4e-26 91.5 0.0 5.7e-26 90.3 0.0 1.7 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EFE41299.1 - 6.1e-13 48.4 0.3 1.5e-12 47.1 0.2 1.7 2 0 0 2 2 2 1 zinc-finger of acetyl-transferase ESCO FSA_C PF10479.9 EFE41299.1 - 0.0091 14.2 16.0 0.014 13.5 16.0 1.2 1 0 0 1 1 1 1 Fragile site-associated protein C-terminus Mucin PF01456.17 EFE41299.1 - 0.019 15.0 43.6 0.019 15.0 43.6 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein SOG2 PF10428.9 EFE41299.1 - 8 5.5 22.9 12 5.0 22.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein NAD_binding_6 PF08030.12 EFE41301.1 - 7.5e-34 117.1 0.0 1.2e-33 116.4 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFE41301.1 - 3.3e-23 81.8 0.1 2.2e-22 79.2 0.0 2.4 3 0 0 3 3 3 1 FAD-binding domain Ferric_reduct PF01794.19 EFE41301.1 - 1.6e-13 50.9 13.0 3.2e-13 49.9 13.0 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 EFE41301.1 - 0.018 15.3 0.0 0.04 14.3 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFE41301.1 - 0.076 13.7 0.0 0.26 11.9 0.0 2.0 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain DUF2244 PF10003.9 EFE41301.1 - 1.6 8.4 4.2 3.9 7.2 4.2 1.6 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) eIF2A PF08662.11 EFE41302.1 - 2.5e-84 282.0 0.1 8.8e-83 276.9 0.0 2.2 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EFE41302.1 - 0.013 16.3 1.0 1.9 9.5 0.1 4.0 3 1 1 4 4 4 0 WD domain, G-beta repeat FlaG PF03646.15 EFE41302.1 - 0.35 11.1 0.1 0.35 11.1 0.1 2.2 2 0 0 2 2 2 0 FlaG protein PRP38_assoc PF12871.7 EFE41302.1 - 0.84 10.3 17.1 2 9.1 17.1 1.6 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Sec62 PF03839.16 EFE41303.1 - 5.2 6.5 7.0 6 6.3 7.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF1203 PF06718.11 EFE41305.1 - 1.6e-36 125.1 0.0 1.9e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1203) CorA PF01544.18 EFE41306.1 - 2.8e-15 56.4 1.2 4.9e-15 55.6 1.2 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein STE PF02200.16 EFE41306.1 - 0.066 13.6 0.0 0.21 12.0 0.0 1.8 2 0 0 2 2 2 0 STE like transcription factor TFIID_20kDa PF03847.13 EFE41307.1 - 1.1e-23 83.5 0.0 1.8e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 EFE41307.1 - 0.11 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone F-box PF00646.33 EFE41309.1 - 0.00012 21.8 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE41309.1 - 0.024 14.5 0.3 0.067 13.1 0.3 1.7 1 0 0 1 1 1 0 F-box-like DASH_Spc34 PF08657.10 EFE41310.1 - 7.7e-44 150.4 7.2 1.6e-21 77.2 4.0 2.1 1 1 1 2 2 2 2 DASH complex subunit Spc34 DASH_Spc19 PF08287.11 EFE41310.1 - 0.0069 16.3 4.2 0.016 15.1 4.2 1.6 1 0 0 1 1 1 1 Spc19 DUF848 PF05852.11 EFE41310.1 - 0.013 15.6 4.6 0.027 14.6 4.6 1.5 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) VSG_B PF13206.6 EFE41310.1 - 0.08 12.2 0.2 0.13 11.5 0.2 1.3 1 0 0 1 1 1 0 Trypanosomal VSG domain Rtt102p PF09510.10 EFE41310.1 - 0.15 12.2 0.7 0.31 11.2 0.7 1.4 1 0 0 1 1 1 0 Rtt102p-like transcription regulator protein Prefoldin_2 PF01920.20 EFE41310.1 - 0.82 9.7 8.2 5.5 7.0 0.9 2.9 3 0 0 3 3 3 0 Prefoldin subunit Rpn3_C PF08375.11 EFE41311.1 - 9.1e-26 90.1 0.6 9.1e-26 90.1 0.6 2.4 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EFE41311.1 - 1.8e-21 76.6 0.1 7.7e-21 74.6 0.0 2.1 2 0 0 2 2 2 1 PCI domain polyprenyl_synt PF00348.17 EFE41312.1 - 1.7e-67 227.2 0.0 2.2e-66 223.5 0.0 2.0 1 1 0 1 1 1 1 Polyprenyl synthetase DUF3659 PF12396.8 EFE41312.1 - 0.045 13.7 0.0 0.62 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) Ank_2 PF12796.7 EFE41313.1 - 1.5e-19 70.4 1.2 6.7e-11 42.6 1.1 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE41313.1 - 1e-16 61.0 1.3 6.6e-07 29.8 0.4 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFE41313.1 - 8.6e-16 57.6 5.3 0.0034 17.7 0.1 4.7 4 1 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EFE41313.1 - 4.4e-14 52.4 3.6 0.0073 16.6 0.0 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE41313.1 - 5.3e-12 44.8 0.3 0.017 15.6 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat zf-CCHC PF00098.23 EFE41314.1 - 0.087 12.9 0.2 7.9 6.7 0.2 2.5 2 0 0 2 2 2 0 Zinc knuckle BPL_LplA_LipB PF03099.19 EFE41315.1 - 8.6e-07 28.9 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Ras PF00071.22 EFE41316.1 - 2.6e-26 92.2 0.0 3.1e-26 91.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE41316.1 - 2.1e-12 47.3 0.0 2.7e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE41316.1 - 0.00038 20.0 0.0 0.00041 19.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFE41316.1 - 0.039 13.3 0.0 0.045 13.1 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region CWC25 PF12542.8 EFE41318.1 - 1.4e-25 90.2 0.4 1.4e-25 90.2 0.4 4.1 3 1 1 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 EFE41318.1 - 9e-14 51.4 10.3 9e-14 51.4 10.3 5.3 5 2 2 7 7 7 1 N-terminal domain of CBF1 interacting co-repressor CIR PCI PF01399.27 EFE41319.1 - 3.8e-16 59.5 0.5 9.1e-16 58.3 0.1 1.8 2 0 0 2 2 2 1 PCI domain TPR_7 PF13176.6 EFE41319.1 - 0.0032 17.4 0.1 0.12 12.4 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE41319.1 - 0.0043 16.7 0.3 0.049 13.3 0.1 2.9 2 0 0 2 2 2 1 TPR repeat DUF4423 PF14394.6 EFE41319.1 - 0.0092 15.7 0.0 4.2 7.0 0.0 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF4423) TPR_2 PF07719.17 EFE41319.1 - 0.011 15.8 4.4 0.095 12.9 0.0 4.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFE41319.1 - 0.018 15.4 0.3 0.51 10.7 0.0 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFE41319.1 - 0.024 15.4 0.1 1.3 10.1 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFE41319.1 - 0.056 13.3 2.5 0.37 10.7 0.0 3.5 5 0 0 5 5 5 0 Tetratricopeptide repeat CorA PF01544.18 EFE41319.1 - 0.06 12.7 0.3 0.13 11.5 0.3 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Jagunal PF07086.12 EFE41320.1 - 0.16 12.0 2.7 0.32 11.0 2.7 1.6 1 1 0 1 1 1 0 Jagunal, ER re-organisation during oogenesis RELT PF12606.8 EFE41320.1 - 3.6 6.6 4.8 2.9 7.0 0.2 2.4 2 0 0 2 2 2 0 Tumour necrosis factor receptor superfamily member 19 Herpes_LMP1 PF05297.11 EFE41320.1 - 6.6 5.8 8.7 0.91 8.7 5.0 1.4 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Peptidase_C65 PF10275.9 EFE41321.1 - 4e-62 209.9 0.0 5.3e-62 209.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain Putative_PNPOx PF01243.20 EFE41322.1 - 3.6e-12 46.3 0.0 7.3e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 EFE41322.1 - 0.066 13.2 0.0 0.19 11.7 0.0 1.7 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase NIPSNAP PF07978.13 EFE41323.1 - 2.4e-41 140.1 0.4 1.3e-29 102.4 0.1 2.3 2 0 0 2 2 2 2 NIPSNAP SR-25 PF10500.9 EFE41323.1 - 1.2 8.7 10.1 2.1 7.9 10.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MSA-2c PF12238.8 EFE41323.1 - 4.4 7.3 9.5 7.3 6.5 9.5 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c RR_TM4-6 PF06459.12 EFE41325.1 - 0.3 10.9 3.4 0.33 10.7 3.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SRP-alpha_N PF04086.13 EFE41325.1 - 2 8.3 11.2 2.4 8.0 11.2 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal S4 PF01479.25 EFE41326.1 - 2.9e-15 55.7 0.0 7.2e-15 54.4 0.0 1.7 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 EFE41326.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 S4 domain Pex14_N PF04695.13 EFE41326.1 - 1.5 9.5 16.5 0.38 11.4 11.3 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF572 PF04502.13 EFE41326.1 - 3.3 7.2 19.7 5.3 6.6 19.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) CCDC53 PF10152.9 EFE41326.1 - 3.4 8.1 11.7 24 5.3 7.9 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex PAP1 PF08601.10 EFE41326.1 - 4.4 6.9 23.2 6.5 6.4 23.2 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Abhydrolase_1 PF00561.20 EFE41327.1 - 3.5e-10 40.0 0.2 0.00018 21.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE41327.1 - 2.7e-07 31.4 1.3 9.9e-06 26.3 1.3 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family LCAT PF02450.15 EFE41327.1 - 0.22 10.7 0.1 0.3 10.2 0.1 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase APH PF01636.23 EFE41328.1 - 4.6e-09 36.5 1.4 1.9e-08 34.5 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFE41328.1 - 0.044 13.1 0.0 0.069 12.4 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase DUF4902 PF16245.5 EFE41328.1 - 0.095 12.6 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4902) AA_permease_2 PF13520.6 EFE41329.1 - 1.5e-62 211.8 43.3 2e-62 211.4 43.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE41329.1 - 5.2e-28 97.9 44.4 2.9e-25 88.8 44.4 2.1 1 1 0 1 1 1 1 Amino acid permease NAD_binding_1 PF00175.21 EFE41330.1 - 6e-08 33.3 0.0 7.4e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFE41330.1 - 0.00019 21.7 0.0 0.00058 20.2 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EFE41330.1 - 0.12 12.5 0.0 0.36 10.9 0.0 1.8 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Aminotran_5 PF00266.19 EFE41331.1 - 1.3e-30 106.7 0.0 2.6e-18 66.1 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Aconitase PF00330.20 EFE41332.1 - 2.4e-113 379.6 0.2 2e-112 376.5 0.2 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFE41332.1 - 5.1e-24 85.1 0.0 1.2e-23 83.8 0.0 1.7 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF5068 PF16781.5 EFE41332.1 - 0.044 13.5 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5068) Peptidase_M22 PF00814.25 EFE41333.1 - 1.7e-84 283.7 0.0 2.3e-84 283.3 0.0 1.2 1 0 0 1 1 1 1 Glycoprotease family SET PF00856.28 EFE41334.1 - 6.2e-13 49.5 0.0 1.3e-12 48.4 0.0 1.5 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 EFE41334.1 - 2e-10 41.5 0.0 5.1e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding EPL1 PF10513.9 EFE41335.1 - 8.3e-21 75.0 0.3 8.3e-21 75.0 0.3 2.8 2 1 1 3 3 3 1 Enhancer of polycomb-like EF-hand_1 PF00036.32 EFE41336.1 - 1.9e-19 67.7 11.6 4.9e-08 32.0 0.5 3.2 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EFE41336.1 - 1.3e-15 57.5 4.9 8.9e-14 51.7 1.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFE41336.1 - 5.2e-14 50.9 5.2 3.2e-05 23.5 0.2 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EFE41336.1 - 3e-12 45.4 7.5 1.1e-06 27.8 0.3 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EFE41336.1 - 9.4e-12 44.6 5.9 3.6e-05 23.5 0.1 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EFE41336.1 - 5e-05 23.2 5.8 0.0083 16.1 0.3 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFE41336.1 - 0.0017 18.6 0.0 0.0032 17.8 0.0 1.5 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EFE41336.1 - 0.034 14.5 0.0 0.37 11.1 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 EFE41336.1 - 0.15 12.3 1.2 0.72 10.1 1.2 2.1 1 1 0 1 1 1 0 Dockerin type I domain Arylsulfotran_2 PF14269.6 EFE41337.1 - 3.3e-111 371.4 0.2 4.7e-111 370.9 0.2 1.2 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EFE41337.1 - 8.9e-17 61.0 0.1 2.9e-15 56.1 0.1 2.2 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) Pkinase PF00069.25 EFE41338.1 - 3.7e-32 111.7 0.0 9.4e-32 110.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41338.1 - 4.7e-10 39.2 0.0 8.8e-09 35.0 0.0 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinocilin PF15033.6 EFE41339.1 - 0.045 13.4 0.3 0.054 13.1 0.3 1.1 1 0 0 1 1 1 0 Kinocilin protein HA2 PF04408.23 EFE41340.1 - 2.6e-17 63.0 0.5 6.9e-17 61.7 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFE41340.1 - 4e-14 52.9 0.0 8.8e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RWD PF05773.22 EFE41340.1 - 7.6e-11 42.3 0.1 1.9e-10 41.1 0.1 1.7 1 0 0 1 1 1 1 RWD domain DEAD PF00270.29 EFE41340.1 - 2.8e-10 40.2 0.0 5.2e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 EFE41340.1 - 1.9e-06 28.1 0.0 4e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DND1_DSRM PF14709.7 EFE41340.1 - 0.0048 17.1 0.0 0.013 15.8 0.0 1.8 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_22 PF13401.6 EFE41340.1 - 0.005 17.1 0.8 0.029 14.6 0.8 2.3 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFE41340.1 - 0.0085 15.2 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 EFE41340.1 - 0.022 14.5 0.0 0.08 12.7 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain CoA_trans PF01144.23 EFE41340.1 - 0.026 13.9 0.0 0.05 13.0 0.0 1.4 1 0 0 1 1 1 0 Coenzyme A transferase ATPase PF06745.13 EFE41340.1 - 0.028 13.8 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 KaiC UBA PF00627.31 EFE41340.1 - 0.032 14.2 0.0 0.4 10.6 0.0 2.9 3 0 0 3 3 3 0 UBA/TS-N domain dsRBD2 PF17842.1 EFE41340.1 - 0.034 14.3 0.0 0.078 13.2 0.0 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 AAA_23 PF13476.6 EFE41340.1 - 0.054 14.0 0.1 0.16 12.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain BTRD1 PF17660.1 EFE41340.1 - 0.11 12.4 0.1 1.9 8.4 0.2 2.7 3 0 0 3 3 2 0 Bacterial tandem repeat domain 1 TRAP_alpha PF03896.16 EFE41341.1 - 1.3e-13 50.9 0.0 3.8e-13 49.3 0.0 1.7 1 1 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit 6PF2K PF01591.18 EFE41342.1 - 0.032 13.5 1.2 0.052 12.9 1.2 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase zf-CCCH_4 PF18044.1 EFE41342.1 - 1.2 9.0 10.3 0.36 10.7 2.1 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger POT1PC PF16686.5 EFE41343.1 - 9.6e-47 158.7 2.9 1.2e-45 155.2 2.3 2.4 2 0 0 2 2 2 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 EFE41343.1 - 2.9e-21 75.8 0.0 8.1e-21 74.4 0.0 1.8 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 IBB PF01749.20 EFE41344.1 - 5.1e-20 71.7 1.1 5.5e-20 71.6 1.1 1.0 1 0 0 1 1 1 1 Importin beta binding domain NUSAP PF16006.5 EFE41344.1 - 0.02 14.7 7.8 0.022 14.5 7.8 1.0 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein Arm PF00514.23 EFE41345.1 - 1.8e-95 310.4 11.0 1.9e-14 53.1 0.0 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 EFE41345.1 - 3.5e-22 77.7 4.3 4.8e-22 77.3 2.9 1.9 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_2 PF13646.6 EFE41345.1 - 9.7e-21 74.0 0.1 3.2e-09 37.0 0.0 5.0 2 2 3 5 5 5 4 HEAT repeats HEAT_EZ PF13513.6 EFE41345.1 - 1e-20 73.8 4.3 1.3e-08 35.1 0.0 6.0 4 1 2 6 6 6 4 HEAT-like repeat HEAT PF02985.22 EFE41345.1 - 5.4e-19 66.7 0.2 1.5e-05 24.9 0.0 7.0 7 0 0 7 7 7 4 HEAT repeat Arm_2 PF04826.13 EFE41345.1 - 3e-08 33.4 0.0 0.0043 16.6 0.0 3.8 2 1 2 4 4 4 3 Armadillo-like V-ATPase_H_C PF11698.8 EFE41345.1 - 1.1e-05 25.6 0.0 0.95 9.6 0.0 4.6 3 2 2 5 5 5 2 V-ATPase subunit H Adaptin_N PF01602.20 EFE41345.1 - 2e-05 23.4 0.0 0.0041 15.8 0.0 2.8 1 1 2 3 3 3 1 Adaptin N terminal region HEAT_PBS PF03130.16 EFE41345.1 - 0.00032 21.1 1.5 0.79 10.6 0.1 4.8 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Cnd1 PF12717.7 EFE41345.1 - 0.00084 19.4 0.0 3.8 7.5 0.0 3.2 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 CTNNBL PF08216.11 EFE41345.1 - 0.002 18.2 0.0 29 4.9 0.0 4.5 5 0 0 5 5 5 0 Catenin-beta-like, Arm-motif containing nuclear Atx10homo_assoc PF09759.9 EFE41345.1 - 0.015 15.3 0.1 11 6.1 0.0 3.1 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Gcn1_N PF12074.8 EFE41345.1 - 0.043 13.1 0.0 10 5.3 0.0 2.5 2 1 1 3 3 3 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal RICTOR_V PF14668.6 EFE41345.1 - 0.055 13.7 5.2 2.3 8.5 0.2 4.7 4 2 2 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 NopRA1 PF16201.5 EFE41345.1 - 0.077 12.6 0.0 31 4.1 0.0 3.8 2 1 2 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 Mo25 PF08569.11 EFE41345.1 - 0.09 12.1 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Mo25-like Amidase PF01425.21 EFE41346.1 - 1.2e-93 314.6 0.0 3.3e-93 313.1 0.0 1.7 1 1 0 1 1 1 1 Amidase p450 PF00067.22 EFE41347.1 - 1.7e-60 205.1 0.0 1.9e-60 205.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4485 PF14846.6 EFE41347.1 - 0.28 11.3 1.4 1.3 9.1 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4485) MFS_1 PF07690.16 EFE41348.1 - 1.9e-18 66.6 26.4 6.8e-15 54.8 16.8 3.0 3 0 0 3 3 3 3 Major Facilitator Superfamily Trs65 PF12735.7 EFE41350.1 - 4.8e-63 213.5 0.1 1.3e-62 212.0 0.1 1.7 1 1 0 1 1 1 1 TRAPP trafficking subunit Trs65 FF PF01846.19 EFE41351.1 - 8.8e-60 198.7 16.2 3.3e-15 56.0 0.0 7.1 6 1 0 6 6 6 5 FF domain WW PF00397.26 EFE41351.1 - 1.4e-09 37.9 1.2 3.1e-09 36.8 1.2 1.7 1 0 0 1 1 1 1 WW domain RhoGAP-FF1 PF16512.5 EFE41351.1 - 0.02 15.6 12.8 0.53 11.0 0.1 4.5 3 1 1 4 4 4 0 p190-A and -B Rho GAPs FF domain HycH PF07450.11 EFE41351.1 - 0.067 13.6 0.6 0.27 11.6 0.6 2.1 1 0 0 1 1 1 0 Formate hydrogenlyase maturation protein HycH EMP24_GP25L PF01105.24 EFE41351.1 - 0.14 12.1 1.0 0.35 10.8 1.0 1.7 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD SesA PF17107.5 EFE41351.1 - 9.3 6.5 8.6 0.72 10.0 0.6 3.2 3 1 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ABC_tran PF00005.27 EFE41352.1 - 4.5e-34 117.9 0.0 1.9e-15 57.6 0.0 2.8 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 EFE41352.1 - 3.9e-11 42.8 2.2 0.0031 17.0 0.0 3.9 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFE41352.1 - 1.8e-09 37.8 4.9 0.35 10.6 2.0 4.6 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EFE41352.1 - 2e-06 27.8 0.0 0.048 13.6 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain RLI PF04068.15 EFE41352.1 - 2.1e-05 24.2 9.2 7.8e-05 22.4 4.4 2.9 3 0 0 3 3 2 2 Possible Fer4-like domain in RNase L inhibitor, RLI AAA PF00004.29 EFE41352.1 - 2.2e-05 24.9 0.1 0.022 15.2 0.1 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EFE41352.1 - 3.3e-05 23.8 0.4 0.24 11.1 0.0 3.0 2 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EFE41352.1 - 5.2e-05 23.5 0.0 0.01 16.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain Fer4 PF00037.27 EFE41352.1 - 8.8e-05 22.2 2.5 8.8e-05 22.2 2.5 2.6 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_16 PF13191.6 EFE41352.1 - 0.00015 22.2 0.0 0.04 14.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 EFE41352.1 - 0.00039 20.8 0.1 0.26 11.7 0.0 3.1 4 0 0 4 4 2 1 RNA helicase AAA_7 PF12775.7 EFE41352.1 - 0.0004 20.0 1.1 0.0038 16.8 0.2 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EFE41352.1 - 0.0006 19.7 0.2 1 9.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EFE41352.1 - 0.0013 19.2 0.1 2.2 8.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFE41352.1 - 0.0014 18.4 0.4 1 9.2 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_24 PF13479.6 EFE41352.1 - 0.0021 17.8 2.1 0.12 12.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain Fer4_21 PF14697.6 EFE41352.1 - 0.0021 18.2 8.4 0.0044 17.1 8.4 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain SRP54 PF00448.22 EFE41352.1 - 0.0032 17.1 2.9 0.067 12.8 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain TsaE PF02367.17 EFE41352.1 - 0.0061 16.6 0.1 0.093 12.7 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFE41352.1 - 0.007 16.3 2.1 0.33 10.9 0.0 2.5 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 EFE41352.1 - 0.0072 15.5 1.6 1.7 7.8 0.0 3.4 3 1 1 4 4 4 1 NB-ARC domain Fer4_6 PF12837.7 EFE41352.1 - 0.0094 16.0 2.2 0.0094 16.0 2.2 2.5 2 1 0 2 2 2 1 4Fe-4S binding domain Thymidylate_kin PF02223.17 EFE41352.1 - 0.01 15.5 0.2 5 6.8 0.0 3.0 3 0 0 3 3 3 0 Thymidylate kinase AAA_33 PF13671.6 EFE41352.1 - 0.013 15.7 0.0 2.1 8.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFE41352.1 - 0.017 14.8 0.4 0.69 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_9 PF13187.6 EFE41352.1 - 0.026 14.7 8.8 0.048 13.8 8.3 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFE41352.1 - 0.029 14.5 1.7 0.029 14.5 1.7 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain AAA_5 PF07728.14 EFE41352.1 - 0.031 14.3 0.1 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EFE41352.1 - 0.032 14.7 2.8 0.65 10.5 0.2 2.4 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFE41352.1 - 0.033 14.4 0.1 4.7 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 EFE41352.1 - 0.035 12.7 0.0 0.077 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Fer4_16 PF13484.6 EFE41352.1 - 0.057 14.4 5.2 0.09 13.7 0.2 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain TniB PF05621.11 EFE41352.1 - 0.069 12.5 0.1 0.37 10.2 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein VirE PF05272.11 EFE41352.1 - 0.078 12.7 0.0 4.8 6.9 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E DnaB_C PF03796.15 EFE41352.1 - 0.12 11.7 0.0 0.3 10.4 0.0 1.6 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Fer4_17 PF13534.6 EFE41352.1 - 0.14 12.7 0.2 0.14 12.7 0.2 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain PduV-EutP PF10662.9 EFE41352.1 - 0.31 10.8 2.3 0.31 10.8 0.1 2.1 2 0 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation Fer4_7 PF12838.7 EFE41352.1 - 0.38 11.4 10.1 0.095 13.3 1.6 2.2 1 1 2 3 3 3 0 4Fe-4S dicluster domain NTPase_1 PF03266.15 EFE41352.1 - 0.53 10.2 3.2 5 7.0 0.1 2.8 3 0 0 3 3 2 0 NTPase Fer4_8 PF13183.6 EFE41352.1 - 6.8 7.2 10.9 2.1 8.9 2.3 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain SNF2_N PF00176.23 EFE41353.1 - 3.8e-56 190.3 0.0 1.1e-55 188.8 0.0 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain Chromo PF00385.24 EFE41353.1 - 1e-24 86.2 0.4 1.6e-15 56.7 0.1 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 EFE41353.1 - 3e-21 75.6 0.0 2.9e-20 72.5 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) Helicase_C PF00271.31 EFE41353.1 - 6.5e-18 65.1 0.1 2.1e-17 63.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Cdh1_DBD_1 PF18196.1 EFE41353.1 - 1.7e-06 28.4 6.9 4.4e-06 27.0 2.1 4.5 4 1 1 5 5 5 2 Chromodomain helicase DNA-binding domain 1 HDA2-3 PF11496.8 EFE41353.1 - 2.8e-06 26.7 0.0 9.9e-06 24.9 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EFE41353.1 - 1.1e-05 25.5 0.2 0.00016 21.7 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 EFE41353.1 - 0.015 15.5 0.3 0.14 12.3 0.0 2.9 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain SLIDE PF09111.10 EFE41353.1 - 0.039 14.0 0.0 0.4 10.7 0.0 2.8 1 1 1 2 2 2 0 SLIDE AAA_22 PF13401.6 EFE41353.1 - 0.058 13.7 0.0 0.26 11.5 0.0 2.2 1 0 0 1 1 1 0 AAA domain CDH1_2_SANT_HL1 PF18375.1 EFE41353.1 - 0.092 13.4 1.6 0.6 10.8 1.1 2.8 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 zf-H2C2_2 PF13465.6 EFE41354.1 - 1.9e-06 28.1 2.2 8.5e-05 22.8 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EFE41354.1 - 0.043 13.8 0.4 0.11 12.5 0.4 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE41354.1 - 0.098 13.2 0.7 14 6.4 0.0 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type Zap1_zf2 PF18217.1 EFE41354.1 - 0.54 10.3 6.9 3 7.9 0.7 2.5 2 0 0 2 2 2 0 Zap1 zinc finger 2 FOXP-CC PF16159.5 EFE41354.1 - 0.92 10.2 7.6 0.37 11.4 1.5 2.8 2 1 1 3 3 3 0 FOXP coiled-coil domain PGK PF00162.19 EFE41355.1 - 2.7e-148 494.0 0.2 3e-148 493.8 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 EFE41355.1 - 0.00096 19.1 0.3 0.026 14.6 0.0 2.9 3 0 0 3 3 3 1 PA domain DUF3530 PF12048.8 EFE41355.1 - 0.21 11.0 0.0 0.31 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) FIVAR PF07554.13 EFE41355.1 - 1.8 9.4 3.8 41 5.0 0.0 3.0 3 1 1 4 4 4 0 FIVAR domain DSS1_SEM1 PF05160.13 EFE41356.1 - 2.1e-19 69.3 13.0 3.2e-19 68.8 13.0 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family DUF3808 PF10300.9 EFE41357.1 - 3.6e-144 481.1 0.0 4.4e-144 480.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) CIDR1_gamma PF18562.1 EFE41357.1 - 0.0051 16.9 0.1 0.015 15.4 0.1 1.7 1 0 0 1 1 1 1 Cysteine-Rich Interdomain Region 1 gamma Nup160 PF11715.8 EFE41358.1 - 2.1e-131 439.3 9.0 3.1e-131 438.7 9.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Rad51 PF08423.11 EFE41359.1 - 2.7e-128 426.6 0.0 3.5e-128 426.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EFE41359.1 - 1.6e-09 37.6 0.0 2.6e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 EFE41359.1 - 8.9e-08 31.9 0.0 1.3e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EFE41359.1 - 0.00016 21.1 0.7 0.00073 18.9 0.7 2.0 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EFE41359.1 - 0.012 15.0 0.1 0.048 13.0 0.0 1.8 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain HHH PF00633.23 EFE41359.1 - 0.028 14.3 0.4 12 5.9 0.1 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif ssDNA_TraI_N PF18272.1 EFE41359.1 - 0.07 13.1 0.7 0.24 11.4 0.1 2.1 3 0 0 3 3 3 0 single-stranded DNA binding TraI N-terminal subdomain PAXNEB PF05625.11 EFE41359.1 - 0.12 11.5 0.2 0.41 9.7 0.1 1.8 2 0 0 2 2 2 0 PAXNEB protein HHH_5 PF14520.6 EFE41359.1 - 0.17 12.5 1.1 26 5.5 0.1 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix domain CPL PF08144.11 EFE41362.1 - 1.7e-33 116.0 0.0 2.5e-29 102.5 0.0 3.6 4 0 0 4 4 4 2 CPL (NUC119) domain Hid1 PF12722.7 EFE41362.1 - 0.1 10.7 2.5 0.17 10.0 2.5 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RRN3 PF05327.11 EFE41362.1 - 0.59 8.6 13.5 13 4.2 11.4 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2722 PF10846.8 EFE41362.1 - 2.6 6.9 15.5 4.2 6.2 15.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Sporozoite_P67 PF05642.11 EFE41362.1 - 3.6 5.5 10.6 6.8 4.6 10.6 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 EFE41362.1 - 3.8 5.7 21.5 6.4 4.9 21.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFE41362.1 - 6.1 4.9 26.2 9.9 4.2 26.2 1.2 1 0 0 1 1 1 0 Nop14-like family DUF3682 PF12446.8 EFE41363.1 - 0.17 12.4 2.7 0.17 12.4 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Gti1_Pac2 PF09729.9 EFE41364.1 - 1.1e-63 214.6 9.1 4.5e-60 202.8 0.0 3.5 3 1 0 3 3 3 2 Gti1/Pac2 family TCP PF03634.13 EFE41364.1 - 0.44 11.1 12.6 1.5 9.3 3.0 2.3 2 0 0 2 2 2 0 TCP family transcription factor CDP-OH_P_transf PF01066.21 EFE41365.1 - 8.5e-16 58.5 3.1 1.2e-15 58.0 0.7 2.0 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Sld7_C PF18596.1 EFE41366.1 - 3.4e-11 43.1 0.0 1.8e-10 40.8 0.0 2.2 1 1 0 1 1 1 1 Sld7 C-terminal domain Vps55 PF04133.14 EFE41367.1 - 2.6e-45 153.2 8.9 2.9e-45 153.0 8.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF4231 PF14015.6 EFE41367.1 - 0.59 10.6 0.0 0.59 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Proteasome PF00227.26 EFE41368.1 - 8.5e-49 165.6 0.4 1.1e-48 165.3 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFE41368.1 - 1.4e-07 31.0 1.3 2.3e-07 30.4 0.4 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Flg_hook PF02120.16 EFE41368.1 - 0.061 13.2 0.4 30 4.6 0.1 3.2 3 0 0 3 3 3 0 Flagellar hook-length control protein FliK Lysine_decarbox PF03641.14 EFE41369.1 - 1.4e-29 102.8 0.0 2.1e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EFE41369.1 - 0.0015 18.2 1.0 0.0022 17.6 0.1 1.7 2 0 0 2 2 2 1 SLOG cluster4 family LSDAT_prok PF18171.1 EFE41369.1 - 0.03 13.6 0.1 0.042 13.1 0.1 1.2 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote Med6 PF04934.14 EFE41370.1 - 6.2e-10 39.0 0.0 1.6e-09 37.7 0.1 1.7 1 1 1 2 2 2 1 MED6 mediator sub complex component RdRP PF05183.12 EFE41371.1 - 1.1e-179 598.9 0.0 1.3e-179 598.6 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Lsm_C PF14894.6 EFE41371.1 - 0.14 12.0 0.0 0.64 9.8 0.0 2.2 1 0 0 1 1 1 0 Lsm C-terminal Pro-kuma_activ PF09286.11 EFE41373.1 - 1e-30 106.9 0.3 3e-30 105.4 0.3 1.8 1 1 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFE41373.1 - 0.00029 20.2 0.3 0.0015 17.8 0.0 2.1 2 1 0 2 2 2 1 Subtilase family DUF3684 PF12449.8 EFE41374.1 - 0 1429.2 0.0 0 1428.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 EFE41374.1 - 0.00015 21.6 0.0 0.00044 20.1 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase WLM PF08325.10 EFE41374.1 - 0.065 13.3 0.2 0.065 13.3 0.2 2.3 2 0 0 2 2 2 0 WLM domain UPF0767 PF15990.5 EFE41374.1 - 0.83 9.8 2.6 2.9 8.1 2.6 1.9 1 0 0 1 1 1 0 UPF0767 family DUF1117 PF06547.12 EFE41374.1 - 2.8 8.5 4.0 0.93 10.1 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) TRAPPC9-Trs120 PF08626.11 EFE41375.1 - 0 1318.1 0.0 0 1317.9 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Abhydrolase_1 PF00561.20 EFE41376.1 - 5.9e-12 45.8 0.0 1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE41376.1 - 8.7e-07 28.4 0.0 1.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFE41376.1 - 0.018 15.6 0.0 0.035 14.7 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF1749 PF08538.10 EFE41376.1 - 0.026 13.6 0.0 0.034 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) DUF5301 PF17225.3 EFE41377.1 - 0.023 15.1 3.2 0.024 15.1 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5300) RNA_pol_L_2 PF13656.6 EFE41378.1 - 8.4e-34 115.2 0.0 1.1e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFE41378.1 - 9.6e-14 50.6 0.0 1.4e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain TrmE_N PF10396.9 EFE41379.1 - 3.1e-36 124.2 0.0 6.5e-36 123.2 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MnmE_helical PF12631.7 EFE41379.1 - 2.8e-29 102.8 0.0 1.1e-28 100.8 0.0 1.8 1 1 0 1 1 1 1 MnmE helical domain MMR_HSR1 PF01926.23 EFE41379.1 - 9.2e-18 64.4 0.0 1.7e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFE41379.1 - 8.3e-06 26.0 0.0 1.6e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family FeoB_N PF02421.18 EFE41379.1 - 5.7e-05 22.7 0.1 0.00026 20.5 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EFE41379.1 - 0.00083 18.9 0.1 0.06 12.9 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EFE41379.1 - 0.021 14.5 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Glyco_hydro_3_C PF01915.22 EFE41379.1 - 0.033 14.1 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain DUF5638 PF18688.1 EFE41379.1 - 0.035 14.4 0.1 0.071 13.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5638) RsgA_GTPase PF03193.16 EFE41379.1 - 0.046 13.6 0.3 0.9 9.4 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EFE41379.1 - 0.07 13.7 0.9 0.16 12.5 0.1 1.9 2 1 0 2 2 2 0 ABC transporter MCM PF00493.23 EFE41379.1 - 0.078 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Roc PF08477.13 EFE41379.1 - 0.13 12.4 0.0 0.47 10.7 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FH2 PF02181.23 EFE41380.1 - 2.9e-84 283.3 5.5 2.9e-84 283.3 5.5 2.1 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EFE41380.1 - 5.3e-51 172.9 2.9 3.1e-27 95.4 0.0 3.1 3 0 0 3 3 3 2 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EFE41380.1 - 4.5e-48 163.5 3.3 1.3e-46 158.7 1.3 2.6 1 1 1 2 2 2 2 Diaphanous FH3 Domain 2-Hacid_dh_C PF02826.19 EFE41382.1 - 1.2e-48 164.8 0.0 2e-48 164.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFE41382.1 - 3.8e-16 59.0 0.0 5.7e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Cation_ATPase_C PF00689.21 EFE41383.1 - 0.036 13.8 4.5 0.073 12.8 4.5 1.5 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus Polysacc_synt_C PF14667.6 EFE41383.1 - 1.5 8.8 12.1 1.6 8.8 8.6 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain DUF2754 PF10953.8 EFE41383.1 - 4.1 7.7 5.0 6.6 7.1 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2754) tRNA-synt_1 PF00133.22 EFE41384.1 - 2.4e-54 184.6 0.0 4.2e-24 84.8 0.1 6.0 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EFE41384.1 - 2.2e-38 131.6 0.0 3.5e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EFE41384.1 - 4.3e-31 108.0 1.4 1.7e-23 83.0 0.0 4.4 4 1 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EFE41384.1 - 2.6e-14 53.4 0.0 5.9e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EFE41384.1 - 2.8e-06 26.9 0.0 0.0003 20.3 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain zf-ribbon_3 PF13248.6 EFE41384.1 - 0.085 12.3 1.9 5 6.7 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_2 PF12756.7 EFE41385.1 - 5.8e-21 74.7 5.3 9.2e-21 74.1 5.3 1.3 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) 5_nucleotid PF05761.14 EFE41386.1 - 0.3 10.0 0.0 0.43 9.4 0.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family MBOAT PF03062.19 EFE41387.1 - 3.4e-54 184.5 3.1 6.7e-54 183.5 3.1 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Gly_transf_sug PF04488.15 EFE41388.1 - 1.2e-16 61.2 0.0 2.1e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif DUF4834 PF16118.5 EFE41388.1 - 0.016 16.1 9.9 0.14 13.1 0.4 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) TcdA_TcdB PF12919.7 EFE41388.1 - 0.075 12.3 0.0 0.3 10.3 0.0 1.9 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Eapp_C PF10238.9 EFE41388.1 - 0.21 11.6 0.0 0.21 11.6 0.0 2.7 3 0 0 3 3 3 0 E2F-associated phosphoprotein CDC45 PF02724.14 EFE41388.1 - 0.52 8.5 2.9 0.83 7.9 2.9 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 EFE41388.1 - 2.6 7.7 4.6 6 6.5 4.6 1.6 1 0 0 1 1 1 0 FAM176 family FYDLN_acid PF09538.10 EFE41388.1 - 2.6 8.8 8.1 0.26 12.0 3.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RNA_pol_Rpc4 PF05132.14 EFE41388.1 - 4.3 7.8 6.9 2.6 8.4 2.9 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF5523 PF17661.1 EFE41388.1 - 5.6 6.6 14.3 0.075 12.7 6.7 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5523) PBP1_TM PF14812.6 EFE41388.1 - 7 7.1 12.1 6.1 7.3 4.0 3.0 3 0 0 3 3 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BRF1 PF07741.13 EFE41388.1 - 9.9 6.6 14.9 6.5 7.2 6.6 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain PH PF00169.29 EFE41389.1 - 0.068 13.7 0.0 5.3 7.6 0.0 2.7 2 0 0 2 2 2 0 PH domain LRR_6 PF13516.6 EFE41389.1 - 0.17 12.0 4.4 21 5.5 0.1 4.4 3 0 0 3 3 3 0 Leucine Rich repeat Pet127 PF08634.10 EFE41391.1 - 1e-118 395.7 0.0 1.4e-118 395.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial protein Pet127 GARS_A PF01071.19 EFE41393.1 - 9.9e-84 279.9 0.0 1.6e-83 279.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EFE41393.1 - 8.2e-36 122.7 0.2 5.5e-34 116.8 0.0 3.1 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 EFE41393.1 - 8.3e-36 123.5 0.2 2.6e-35 121.9 0.0 1.9 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 EFE41393.1 - 6.7e-27 93.6 0.8 1.7e-26 92.3 0.8 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EFE41393.1 - 2e-14 54.0 1.4 6.7e-14 52.3 1.4 2.0 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 EFE41393.1 - 0.0002 21.0 0.0 0.00038 20.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EFE41393.1 - 0.00037 20.6 0.1 0.0014 18.7 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EFE41393.1 - 0.00086 18.9 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 EFE41393.1 - 0.0033 17.1 0.0 0.007 16.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Glyco_hydro_18 PF00704.28 EFE41394.1 - 3.9e-78 263.3 7.6 4.9e-78 263.0 7.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 AvrE_T3Es PF11725.8 EFE41394.1 - 0.11 9.7 0.1 0.15 9.3 0.1 1.0 1 0 0 1 1 1 0 AvrE-family Type-III effector proteins (T3Es) Actin PF00022.19 EFE41395.1 - 2.5e-132 441.4 0.0 1e-131 439.3 0.0 1.7 1 1 0 1 1 1 1 Actin Fes1 PF08609.10 EFE41396.1 - 1.7e-28 99.3 7.5 1.8e-28 99.2 3.4 2.2 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.6 EFE41396.1 - 7.7e-15 55.1 1.4 3.3e-07 30.6 0.1 2.1 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 EFE41396.1 - 1.4e-09 38.2 0.1 4.5e-07 30.2 0.0 2.7 2 1 1 3 3 3 2 HEAT-like repeat HEAT PF02985.22 EFE41396.1 - 2.3e-09 36.7 0.0 0.00031 20.7 0.0 2.9 3 0 0 3 3 2 2 HEAT repeat Arm PF00514.23 EFE41396.1 - 3.8e-07 29.9 0.0 0.027 14.5 0.0 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EFE41396.1 - 2e-05 24.7 0.1 5.3e-05 23.3 0.0 1.5 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EFE41396.1 - 0.00036 19.2 0.1 0.00068 18.3 0.0 1.4 2 0 0 2 2 2 1 Adaptin N terminal region SIL1 PF16782.5 EFE41396.1 - 0.0042 16.4 0.0 0.23 10.6 0.0 2.2 1 1 1 2 2 2 1 Nucleotide exchange factor SIL1 RICTOR_V PF14668.6 EFE41396.1 - 0.0064 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, domain 5 TPR_18 PF13512.6 EFE41396.1 - 0.0074 16.4 0.1 0.32 11.1 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat V-ATPase_H_C PF11698.8 EFE41396.1 - 0.011 15.8 0.2 1 9.5 0.1 2.1 1 1 1 2 2 2 0 V-ATPase subunit H V-ATPase_H_N PF03224.14 EFE41396.1 - 0.015 14.6 0.1 0.019 14.3 0.1 1.2 1 0 0 1 1 1 0 V-ATPase subunit H Cytochrom_B562 PF07361.11 EFE41396.1 - 0.19 12.4 2.5 0.52 11.0 0.3 2.2 1 1 0 2 2 2 0 Cytochrome b562 UPF0220 PF05255.11 EFE41397.1 - 3.1e-69 231.8 4.2 3.5e-69 231.6 4.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) G3P_antiterm PF04309.12 EFE41397.1 - 0.065 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator DUF5337 PF17272.2 EFE41397.1 - 1.5 8.7 4.7 5.3 6.9 0.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5337) Pkinase PF00069.25 EFE41399.1 - 3.6e-68 229.8 0.0 6.7e-68 228.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41399.1 - 2.3e-31 109.0 0.0 4.1e-31 108.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EFE41399.1 - 2.5e-12 47.3 0.1 2.5e-12 47.3 0.1 3.1 3 0 0 3 3 3 1 Protein kinase C terminal domain Kinase-like PF14531.6 EFE41399.1 - 7.9e-10 38.5 0.0 3.2e-09 36.5 0.0 1.9 1 1 1 2 2 2 1 Kinase-like C2 PF00168.30 EFE41399.1 - 2.1e-08 34.4 0.0 8.2e-06 26.1 0.0 2.8 2 0 0 2 2 2 1 C2 domain Haspin_kinase PF12330.8 EFE41399.1 - 0.0026 16.7 0.2 0.0026 16.7 0.2 2.4 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFE41399.1 - 0.0087 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Peptidase_S49_N PF08496.10 EFE41399.1 - 0.22 11.6 4.1 0.46 10.5 4.1 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FTA2 PF13095.6 EFE41399.1 - 2.2 7.9 5.4 3.7 7.1 0.1 2.6 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EFE41399.1 - 5.3 6.6 5.6 0.38 10.3 0.1 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase GH-E PF14410.6 EFE41400.1 - 0.0097 16.3 0.5 0.026 14.9 0.5 1.7 1 0 0 1 1 1 1 HNH/ENDO VII superfamily nuclease with conserved GHE residues AAA PF00004.29 EFE41401.1 - 1.2e-40 139.0 0.0 3.5e-40 137.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFE41401.1 - 5.4e-18 64.7 0.3 1.1e-17 63.7 0.3 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EFE41401.1 - 5.3e-09 35.7 0.0 1.3e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EFE41401.1 - 2.5e-05 24.7 0.2 0.014 15.8 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EFE41401.1 - 0.00017 21.6 1.4 0.00072 19.6 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFE41401.1 - 0.0003 20.6 0.0 0.00072 19.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFE41401.1 - 0.0005 20.3 1.0 0.084 13.1 0.0 3.1 2 1 1 3 3 3 1 AAA domain PhoH PF02562.16 EFE41401.1 - 0.0018 17.7 0.2 0.073 12.5 0.1 2.6 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.13 EFE41401.1 - 0.0023 17.2 1.5 0.051 12.7 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_2 PF07724.14 EFE41401.1 - 0.0028 17.8 2.7 0.006 16.7 0.0 2.8 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 EFE41401.1 - 0.0079 15.6 0.1 0.024 14.0 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFE41401.1 - 0.013 15.7 0.0 0.036 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFE41401.1 - 0.068 12.9 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 EFE41401.1 - 0.16 11.5 0.3 0.49 9.9 0.0 2.0 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_11 PF13086.6 EFE41401.1 - 0.53 10.0 0.0 0.53 10.0 0.0 3.2 2 1 0 3 3 2 0 AAA domain CLZ PF16526.5 EFE41401.1 - 1.4 9.3 12.1 0.26 11.7 7.0 2.6 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels RPN2_C PF18004.1 EFE41401.1 - 9.5 6.1 9.9 20 5.0 9.9 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain TauD PF02668.16 EFE41402.1 - 4.8e-22 79.0 0.3 2.9e-15 56.8 0.0 2.0 2 0 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EFE41402.1 - 0.089 11.9 0.1 1.3 8.1 0.0 2.0 2 0 0 2 2 2 0 CsiD MaoC_dehydratas PF01575.19 EFE41403.1 - 9.9e-28 96.2 0.0 1.6e-27 95.5 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EFE41403.1 - 1.9e-09 37.7 0.0 0.00014 22.0 0.0 2.2 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase Methyltransf_25 PF13649.6 EFE41404.1 - 9.6e-12 45.5 0.0 2.3e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFE41404.1 - 1.2e-10 41.3 0.0 1.8e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EFE41404.1 - 2.1e-10 40.6 0.0 3.4e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE41404.1 - 1.2e-07 32.3 0.0 3.4e-07 30.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE41404.1 - 1.1e-06 28.6 0.0 2.1e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EFE41404.1 - 7.3e-06 25.1 0.0 1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EFE41404.1 - 2.4e-05 23.8 0.0 3.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EFE41404.1 - 4.7e-05 23.4 0.1 9.6e-05 22.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFE41404.1 - 0.00029 20.4 0.0 0.00048 19.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EFE41404.1 - 0.00041 21.1 0.0 0.00084 20.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE41404.1 - 0.0037 16.6 0.1 0.0054 16.1 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EFE41404.1 - 0.0066 16.6 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 EFE41404.1 - 0.019 15.0 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EFE41404.1 - 0.03 14.1 0.2 0.049 13.4 0.2 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 EFE41404.1 - 0.032 14.0 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Cons_hypoth95 PF03602.15 EFE41404.1 - 0.033 13.8 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PRMT5 PF05185.16 EFE41404.1 - 0.037 13.9 0.1 0.082 12.7 0.1 1.6 1 1 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Per1 PF04080.13 EFE41405.1 - 1.7e-76 257.4 13.7 2e-76 257.2 13.7 1.0 1 0 0 1 1 1 1 Per1-like family NiFe_hyd_3_EhaA PF17367.2 EFE41405.1 - 0.31 11.2 3.2 7.6 6.7 0.1 2.5 2 0 0 2 2 2 0 NiFe-hydrogenase-type-3 Eha complex subunit A PGM_PMM_I PF02878.16 EFE41406.1 - 4.4e-17 62.1 1.0 4.5e-08 32.9 0.1 3.1 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EFE41406.1 - 3.5e-11 43.1 1.1 9.1e-11 41.8 0.3 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 EFE41406.1 - 0.0004 20.6 0.5 0.0021 18.3 0.5 2.1 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EFE41406.1 - 0.0017 19.0 0.7 0.011 16.3 0.3 2.6 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DEAD PF00270.29 EFE41407.1 - 1.6e-47 161.5 0.0 2.5e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE41407.1 - 1.2e-30 106.1 0.0 1.2e-29 102.9 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE41407.1 - 2.4e-05 24.4 0.0 4.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Brix PF04427.18 EFE41408.1 - 3e-49 167.8 0.2 4.2e-49 167.3 0.2 1.2 1 0 0 1 1 1 1 Brix domain MRNIP PF15749.5 EFE41408.1 - 4.3 8.1 9.9 0.25 12.1 3.8 2.0 2 0 0 2 2 2 0 MRN-interacting protein Lum_binding PF00677.17 EFE41409.1 - 4.3e-36 122.8 0.1 9.2e-20 70.4 0.0 2.2 2 0 0 2 2 2 2 Lumazine binding domain Lumazine_bd_2 PF12893.7 EFE41409.1 - 0.0053 17.4 0.1 0.015 15.9 0.0 1.8 1 1 0 1 1 1 1 Putative lumazine-binding CoA_transf_3 PF02515.17 EFE41410.1 - 9.4e-129 429.7 0.0 1.1e-128 429.5 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III PHD PF00628.29 EFE41411.1 - 9.7e-08 31.8 9.5 1.7e-07 31.0 9.5 1.4 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 EFE41411.1 - 0.53 10.3 7.5 1 9.3 7.5 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 FYVE_2 PF02318.16 EFE41411.1 - 0.54 10.5 2.7 0.92 9.7 2.7 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger PHD_2 PF13831.6 EFE41411.1 - 1.6 8.4 10.2 0.48 10.0 5.6 2.4 2 1 0 2 2 2 0 PHD-finger Band_7 PF01145.25 EFE41412.1 - 6.6e-27 94.6 2.6 1e-26 94.0 2.6 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EFE41412.1 - 0.031 14.0 0.1 0.051 13.3 0.1 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family Ribosomal_L27e PF01777.18 EFE41414.1 - 1.1e-36 125.0 3.8 1.7e-36 124.4 3.8 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family DUF948 PF06103.11 EFE41415.1 - 0.00024 21.3 48.1 0.053 13.8 0.0 13.1 9 4 6 15 15 15 3 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 EFE41415.1 - 0.00029 20.9 47.3 0.12 12.4 0.0 12.0 8 4 4 12 12 12 6 Protein of unknown function (DUF1664) HALZ PF02183.18 EFE41415.1 - 0.58 10.4 10.3 3.1 8.1 2.3 4.7 5 0 0 5 5 5 0 Homeobox associated leucine zipper NPV_P10 PF05531.12 EFE41415.1 - 0.88 10.1 36.3 14 6.2 0.0 11.7 10 1 1 11 11 11 0 Nucleopolyhedrovirus P10 protein SCO1-SenC PF02630.14 EFE41415.1 - 5.9 6.8 6.6 19 5.2 0.0 4.7 4 1 0 5 5 5 0 SCO1/SenC TRAM_LAG1_CLN8 PF03798.16 EFE41416.1 - 8.1e-50 169.3 15.3 1.3e-49 168.7 15.3 1.3 1 0 0 1 1 1 1 TLC domain SWIB PF02201.18 EFE41417.1 - 2.7e-20 72.0 0.0 1.1e-18 66.8 0.0 2.5 2 0 0 2 2 2 2 SWIB/MDM2 domain RPN6_N PF18055.1 EFE41418.1 - 1.1e-44 151.5 1.0 2.5e-44 150.3 0.2 2.1 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EFE41418.1 - 6.4e-20 71.6 1.0 1.2e-19 70.7 0.1 1.9 2 1 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 EFE41418.1 - 1.5e-11 43.8 0.5 4.1e-11 42.4 0.5 1.8 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 EFE41418.1 - 4.6e-06 26.8 13.0 0.0025 18.0 1.2 5.1 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFE41418.1 - 8.1e-06 25.4 4.8 1.7e-05 24.4 2.3 2.2 1 1 1 2 2 2 1 MalT-like TPR region DDRGK PF09756.9 EFE41418.1 - 0.00028 20.5 0.9 0.00049 19.7 0.2 1.7 2 0 0 2 2 2 1 DDRGK domain TPR_1 PF00515.28 EFE41418.1 - 0.00049 19.8 0.3 4.9 7.1 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFE41418.1 - 0.0017 18.3 2.0 5.8 7.2 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFE41418.1 - 0.0034 17.4 3.1 54 4.3 0.3 5.6 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFE41418.1 - 0.0096 16.5 1.7 1.9 9.4 0.1 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFE41418.1 - 0.027 14.6 2.0 70 4.0 0.0 5.4 5 0 0 5 5 4 0 Tetratricopeptide repeat HTH_Crp_2 PF13545.6 EFE41418.1 - 0.074 13.0 0.0 12 6.0 0.0 2.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain NepR PF18557.1 EFE41418.1 - 0.16 11.6 0.9 1.7 8.4 0.1 2.7 2 0 0 2 2 2 0 Anti-sigma factor NepR TPR_6 PF13174.6 EFE41418.1 - 0.37 11.5 6.4 62 4.5 0.0 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat Sof1 PF04158.14 EFE41419.1 - 2.4e-29 101.4 14.7 4.2e-29 100.6 14.7 1.4 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 EFE41419.1 - 1.8e-27 95.0 6.0 1.3e-05 25.8 0.0 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE41419.1 - 4.5e-09 36.5 0.1 0.029 14.7 0.0 4.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE41419.1 - 0.00071 18.6 0.0 0.048 12.6 0.0 2.7 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein adh_short PF00106.25 EFE41420.1 - 7.3e-32 110.4 0.1 1.4e-31 109.5 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE41420.1 - 1.3e-25 90.3 0.0 2.7e-25 89.3 0.0 1.5 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE41420.1 - 0.00013 21.9 0.5 0.00043 20.2 0.5 1.8 1 1 0 1 1 1 1 KR domain DUF2306 PF10067.9 EFE41421.1 - 1.8e-20 73.6 10.7 4.5e-20 72.3 10.7 1.6 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) Glyoxalase PF00903.25 EFE41423.1 - 3.9e-06 27.1 0.0 5.7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EFE41423.1 - 0.00058 19.8 0.0 0.00077 19.4 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain PUF PF00806.19 EFE41424.1 - 6.5e-14 50.7 0.0 1.6 8.6 0.0 8.0 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat Pyridoxal_deC PF00282.19 EFE41425.1 - 1.4e-77 260.9 0.0 1.7e-77 260.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EFE41425.1 - 1.6e-08 34.0 0.0 2.2e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFE41425.1 - 1.2e-05 24.7 0.0 1.3e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 EFE41425.1 - 0.067 11.9 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS RINT1_TIP1 PF04437.13 EFE41426.1 - 1.4e-165 552.0 0.2 5.7e-165 550.0 0.0 2.1 2 1 0 2 2 2 1 RINT-1 / TIP-1 family Nup54 PF13874.6 EFE41426.1 - 0.017 15.2 5.0 0.18 11.9 6.2 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DUF4961 PF16328.5 EFE41426.1 - 0.064 12.6 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4961) SLX9 PF15341.6 EFE41426.1 - 0.099 13.0 3.8 0.2 12.1 3.8 1.5 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Uso1_p115_C PF04871.13 EFE41426.1 - 0.1 12.9 11.6 0.057 13.8 9.3 1.7 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region CRISPR_Cse2 PF09485.10 EFE41426.1 - 0.32 11.5 3.3 1.6 9.3 3.3 2.3 1 0 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) DUF883 PF05957.13 EFE41426.1 - 1.6 9.4 7.4 11 6.8 5.1 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) ALMT PF11744.8 EFE41426.1 - 2 7.2 7.2 3 6.6 7.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter T3SSipB PF16535.5 EFE41426.1 - 2.4 8.6 11.6 2.5 8.6 9.8 1.9 2 0 0 2 2 2 0 Type III cell invasion protein SipB COG2 PF06148.11 EFE41426.1 - 2.8 8.0 7.2 47 4.1 6.7 2.6 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DNA_ligase_A_M PF01068.21 EFE41427.1 - 1e-49 169.0 0.0 5.4e-47 160.1 0.0 2.4 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFE41427.1 - 1.3e-37 129.8 0.0 2.5e-37 128.9 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EFE41427.1 - 1.2e-19 70.7 0.0 4.7e-19 68.8 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region DJ-1_PfpI PF01965.24 EFE41428.1 - 1.4e-11 44.5 0.0 4.2e-11 42.9 0.0 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EFE41428.1 - 0.031 14.0 0.4 0.14 11.8 0.4 2.0 1 1 0 1 1 1 0 ThiJ/PfpI family-like GST_C_2 PF13410.6 EFE41429.1 - 2.8e-07 30.5 0.2 7.1e-07 29.2 0.2 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFE41429.1 - 4.3e-07 30.3 0.0 8.4e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE41429.1 - 1.1e-05 25.6 0.0 2.5e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFE41429.1 - 0.001 19.2 0.0 0.003 17.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFE41429.1 - 0.0016 18.6 0.0 0.003 17.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFE41429.1 - 0.0055 17.0 0.0 0.01 16.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain FA_desaturase PF00487.24 EFE41430.1 - 2.4 7.9 4.8 42 3.9 4.4 2.5 3 0 0 3 3 3 0 Fatty acid desaturase Metallopep PF12044.8 EFE41431.1 - 7.4e-135 449.8 0.0 1.1e-134 449.3 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family NAD_binding_1 PF00175.21 EFE41432.1 - 4e-30 104.7 0.0 6.8e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFE41432.1 - 7.3e-24 84.0 0.0 1.4e-23 83.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EFE41432.1 - 2.4e-08 34.2 0.0 2.5e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Ribosomal_L18A PF01775.17 EFE41433.1 - 2.9e-54 182.3 1.4 3.6e-54 182.0 1.4 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DUF2887 PF11103.8 EFE41433.1 - 0.03 14.4 0.0 0.037 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2887) PCI PF01399.27 EFE41434.1 - 4.7e-10 39.9 0.0 8e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 PCI domain DUF433 PF04255.14 EFE41434.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF433) BTB PF00651.31 EFE41435.1 - 8.8e-08 32.4 0.0 4e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Skp1_POZ PF03931.15 EFE41435.1 - 0.0022 18.1 0.0 0.0043 17.2 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain tRNA-synt_2 PF00152.20 EFE41436.1 - 7.2e-70 235.5 0.0 9.1e-70 235.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFE41436.1 - 6.4e-10 38.9 0.0 1.2e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFE41436.1 - 2.7e-05 23.8 0.0 0.013 14.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) zf-Tim10_DDP PF02953.15 EFE41437.1 - 9.3e-22 76.4 0.6 9.3e-22 76.4 0.6 1.5 1 1 1 2 2 2 1 Tim10/DDP family zinc finger Tom5 PF10642.9 EFE41437.1 - 0.029 14.4 3.9 0.33 11.0 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase SUIM_assoc PF16619.5 EFE41437.1 - 1.7 8.8 5.2 2.5 8.2 5.2 1.5 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Transcrip_act PF04949.13 EFE41438.1 - 0.029 14.2 4.8 0.064 13.1 4.8 1.5 1 0 0 1 1 1 0 Transcriptional activator Fib_alpha PF08702.10 EFE41438.1 - 0.15 12.3 1.5 0.36 11.0 1.5 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EFE41438.1 - 0.71 9.9 3.7 4 7.5 0.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 EFE41438.1 - 0.77 10.0 10.6 0.52 10.5 7.0 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 CLTH PF10607.9 EFE41439.1 - 4.3e-29 101.3 0.0 8.5e-29 100.3 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EFE41439.1 - 4.4e-08 33.0 0.5 9e-08 32.0 0.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 EFE41439.1 - 0.00045 19.7 0.0 0.00079 18.9 0.0 1.4 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_2 PF13639.6 EFE41439.1 - 0.0014 18.9 0.7 0.0026 18.0 0.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFE41439.1 - 0.0028 17.6 0.4 0.0053 16.7 0.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFE41439.1 - 0.016 15.1 0.6 0.03 14.2 0.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFE41439.1 - 0.019 14.8 1.0 0.038 13.9 1.0 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFE41439.1 - 0.027 14.3 1.6 0.054 13.4 1.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE41439.1 - 0.031 14.1 1.0 0.064 13.1 1.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SAD_SRA PF02182.17 EFE41440.1 - 3.6e-26 91.7 0.1 9e-26 90.4 0.1 1.7 1 0 0 1 1 1 1 SAD/SRA domain FAST_1 PF06743.15 EFE41440.1 - 0.07 13.1 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 2OG-FeII_Oxy PF03171.20 EFE41441.1 - 0.00029 21.3 0.0 0.0008 19.9 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Clr2 PF10383.9 EFE41442.1 - 3.4e-22 79.8 0.0 5.9e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 Transcription-silencing protein Clr2 ABC_membrane_2 PF06472.15 EFE41443.1 - 3.7e-88 295.4 0.7 6.7e-88 294.6 0.1 1.8 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFE41443.1 - 2e-18 67.3 0.0 9.7e-18 65.0 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 EFE41443.1 - 0.0011 19.5 0.2 0.045 14.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFE41443.1 - 0.0039 16.9 0.0 0.16 11.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFE41443.1 - 0.014 15.2 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 EFE41443.1 - 0.016 15.7 0.4 0.47 10.9 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFE41443.1 - 0.052 12.9 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EFE41443.1 - 0.084 13.2 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.19 EFE41443.1 - 0.1 12.0 0.1 3.6 6.9 0.1 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Sigma54_activat PF00158.26 EFE41443.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain RuvB_N PF05496.12 EFE41443.1 - 0.18 11.5 0.0 0.47 10.2 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain LRR_4 PF12799.7 EFE41444.1 - 6.1e-31 105.9 43.4 2.9e-08 33.9 5.1 7.3 2 2 6 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFE41444.1 - 1.2e-19 69.9 37.8 9.5e-06 25.3 6.0 6.2 4 2 1 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 EFE41444.1 - 1.2e-13 50.9 19.5 1.3e-06 28.1 4.1 4.2 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 EFE41444.1 - 0.00019 21.3 24.0 0.19 11.8 0.2 7.1 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.33 EFE41444.1 - 0.0022 18.3 31.3 3.2 8.6 0.9 9.1 10 0 0 10 10 10 3 Leucine Rich Repeat NIF PF03031.18 EFE41445.1 - 2.3e-54 183.4 0.5 3.2e-54 182.9 0.5 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Pkinase PF00069.25 EFE41446.1 - 3.7e-25 88.8 0.0 9.6e-25 87.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41446.1 - 2e-07 30.6 0.0 3.2e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE41446.1 - 0.0045 15.8 0.1 0.0065 15.3 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFE41446.1 - 0.0097 15.3 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family NECFESHC PF16621.5 EFE41446.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 Kinase-like PF14531.6 EFE41446.1 - 0.17 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFE41446.1 - 0.22 11.4 0.4 0.49 10.3 0.4 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family RRM_1 PF00076.22 EFE41448.1 - 0.06 13.2 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GHMP_kinases_C PF08544.13 EFE41448.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 GHMP kinases C terminal Aldo_ket_red PF00248.21 EFE41449.1 - 8.1e-43 146.7 0.0 1e-42 146.3 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family RRM_1 PF00076.22 EFE41450.1 - 1e-66 220.7 1.1 4.5e-15 55.2 0.0 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFE41450.1 - 1.1e-05 25.3 0.9 0.0071 16.3 0.0 4.5 6 0 0 6 6 6 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EFE41450.1 - 2.3e-05 24.4 0.0 1.8 8.8 0.0 4.0 3 0 0 3 3 3 3 RNA recognition motif Limkain-b1 PF11608.8 EFE41450.1 - 5.2e-05 23.3 0.1 19 5.4 0.0 5.7 6 0 0 6 6 6 1 Limkain b1 RRM_5 PF13893.6 EFE41450.1 - 0.00012 21.6 0.0 0.021 14.4 0.0 3.1 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFE41450.1 - 0.00013 21.7 0.0 0.19 11.6 0.0 3.8 3 0 0 3 3 3 1 Occluded RNA-recognition motif Pkinase PF00069.25 EFE41451.1 - 1.3e-28 100.1 0.0 1.4e-28 100.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41451.1 - 6.6e-27 94.4 0.0 8.6e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFE41451.1 - 2e-05 24.1 0.0 2.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFE41451.1 - 0.002 17.5 0.0 0.0046 16.3 0.0 1.6 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EFE41451.1 - 0.005 16.5 0.0 0.006 16.2 0.0 1.2 1 0 0 1 1 1 1 RIO1 family YukC PF10140.9 EFE41451.1 - 0.0054 15.6 0.0 0.0073 15.2 0.0 1.1 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Choline_kinase PF01633.20 EFE41451.1 - 0.021 14.4 0.7 0.22 11.1 0.8 2.1 1 1 1 2 2 2 0 Choline/ethanolamine kinase APH PF01636.23 EFE41451.1 - 0.024 14.6 0.0 0.034 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFE41451.1 - 0.036 13.1 0.3 0.21 10.6 0.0 1.9 2 0 0 2 2 2 0 Seadornavirus VP7 PIP49_C PF12260.8 EFE41451.1 - 0.038 13.6 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 HD PF01966.22 EFE41452.1 - 7e-06 26.3 0.1 1.2e-05 25.6 0.1 1.4 1 0 0 1 1 1 1 HD domain Sec61_beta PF03911.16 EFE41453.1 - 2.6e-16 59.3 0.4 4.4e-16 58.6 0.4 1.3 1 0 0 1 1 1 1 Sec61beta family MIG-14_Wnt-bd PF06664.12 EFE41454.1 - 0.0097 15.2 6.0 0.0097 15.2 6.0 3.1 1 1 1 2 2 2 1 Wnt-binding factor required for Wnt secretion DUF1129 PF06570.11 EFE41454.1 - 7.5 6.0 14.0 0.35 10.3 7.7 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) CDC27 PF09507.10 EFE41455.1 - 2.1 7.7 11.5 2.4 7.4 11.5 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TFIIF_alpha PF05793.12 EFE41455.1 - 2.8 6.4 17.7 3.3 6.2 17.7 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 EFE41455.1 - 6 5.0 9.5 7.4 4.7 9.5 1.1 1 0 0 1 1 1 0 CDC45-like protein PCNA_C PF02747.15 EFE41456.1 - 5.5e-52 175.3 0.0 5e-51 172.2 0.0 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 EFE41456.1 - 2.1e-47 160.0 2.9 3.9e-47 159.1 2.9 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad9 PF04139.13 EFE41456.1 - 4e-06 26.5 0.0 5.6e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EFE41456.1 - 0.00029 20.0 0.1 0.00069 18.8 0.1 1.7 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 EFE41456.1 - 0.11 11.5 0.1 3.4 6.7 0.0 2.1 2 1 0 2 2 2 0 Hus1-like protein Vezatin PF12632.7 EFE41457.1 - 3.1e-71 240.0 0.4 9.4e-71 238.4 0.0 1.8 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes MatE PF01554.18 EFE41457.1 - 0.0024 17.6 0.3 0.73 9.5 0.3 2.2 1 1 0 2 2 2 2 MatE TetR_C_9 PF14514.6 EFE41457.1 - 0.0025 18.0 0.2 0.0085 16.2 0.2 1.9 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain DUF2397 PF09660.10 EFE41457.1 - 0.0053 15.7 4.7 0.14 11.0 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2397) DUF2157 PF09925.9 EFE41457.1 - 0.09 12.6 2.3 0.18 11.6 2.3 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Wzy_C PF04932.15 EFE41457.1 - 0.1 12.2 0.2 0.15 11.7 0.2 1.3 1 0 0 1 1 1 0 O-Antigen ligase ALMS_motif PF15309.6 EFE41457.1 - 0.11 12.9 3.1 3.6 8.1 1.1 2.4 2 0 0 2 2 2 0 ALMS motif Polysacc_synt_C PF14667.6 EFE41457.1 - 0.22 11.6 6.5 0.36 10.9 6.5 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain VAD1-2 PF15310.6 EFE41458.1 - 0.0075 16.2 1.9 0.0093 15.9 1.9 1.1 1 0 0 1 1 1 1 Vitamin A-deficiency (VAD) rat model signalling Ank_2 PF12796.7 EFE41459.1 - 8.9e-46 154.4 7.1 6e-10 39.6 0.6 5.6 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE41459.1 - 2.1e-26 91.9 3.1 0.00017 22.1 0.1 7.3 5 2 3 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE41459.1 - 1.1e-25 86.8 1.0 0.021 15.3 0.0 10.3 10 1 0 10 10 10 5 Ankyrin repeat Ank_5 PF13857.6 EFE41459.1 - 1.8e-23 82.3 9.5 5.4e-07 29.8 0.5 7.3 6 1 1 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFE41459.1 - 3.5e-16 58.8 10.5 0.024 15.1 0.3 8.8 9 0 0 9 9 9 4 Ankyrin repeat F-box-like PF12937.7 EFE41459.1 - 0.0013 18.6 0.1 0.0027 17.6 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE41459.1 - 0.055 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 F-box domain CH PF00307.31 EFE41460.1 - 1.1e-08 35.2 0.0 0.00017 21.7 0.0 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain MID_pPIWI_RE PF18157.1 EFE41460.1 - 0.0055 17.0 0.1 0.026 14.8 0.0 2.2 2 0 0 2 2 2 1 MID domain of pPIWI_RE IQ PF00612.27 EFE41460.1 - 0.01 15.5 1.4 0.029 14.1 1.4 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif Rtf2 PF04641.12 EFE41461.1 - 0.00098 18.6 2.1 0.0011 18.4 2.1 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger AP3D1 PF06375.11 EFE41461.1 - 0.0018 18.5 7.6 0.0021 18.3 7.6 1.1 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 MAP65_ASE1 PF03999.12 EFE41461.1 - 0.0072 15.1 3.2 0.0094 14.7 3.2 1.0 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) SHR3_chaperone PF08229.11 EFE41461.1 - 0.031 13.3 1.2 0.039 12.9 1.2 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 DOCK_N PF16172.5 EFE41461.1 - 0.035 13.0 0.0 0.035 13.0 0.0 1.0 1 0 0 1 1 1 0 DOCK N-terminus UPF0239 PF06783.11 EFE41461.1 - 0.039 14.1 7.5 0.053 13.7 7.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) K_trans PF02705.16 EFE41461.1 - 0.075 11.5 0.0 0.079 11.5 0.0 1.0 1 0 0 1 1 1 0 K+ potassium transporter Eapp_C PF10238.9 EFE41461.1 - 0.08 13.0 0.5 0.091 12.8 0.5 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein ETRAMP PF09716.10 EFE41461.1 - 0.08 13.0 4.0 0.13 12.3 4.0 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) TMEM144 PF07857.12 EFE41461.1 - 0.081 11.9 0.0 0.093 11.7 0.0 1.0 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters SR-25 PF10500.9 EFE41461.1 - 0.19 11.3 15.9 0.22 11.1 15.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PPP1R35_C PF15503.6 EFE41461.1 - 0.22 11.3 3.5 0.3 10.9 3.5 1.1 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 35 C-terminus Ctr PF04145.15 EFE41461.1 - 0.23 12.1 0.0 0.26 11.9 0.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Ferlin_C PF16165.5 EFE41461.1 - 0.24 11.4 12.0 0.47 10.4 12.0 1.6 1 1 0 1 1 1 0 Ferlin C-terminus DUF2457 PF10446.9 EFE41462.1 - 6e-150 500.5 38.4 6e-150 500.5 38.4 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF2457) RPOL_N PF14700.6 EFE41462.1 - 0.52 9.6 6.0 0.064 12.6 1.7 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal Arf PF00025.21 EFE41464.1 - 2e-59 200.0 0.0 6.1e-59 198.4 0.0 1.6 1 1 1 2 2 2 1 ADP-ribosylation factor family G-alpha PF00503.20 EFE41464.1 - 4.4e-09 36.0 0.0 1.6e-05 24.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFE41464.1 - 3.6e-08 33.0 0.0 5e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFE41464.1 - 3.8e-06 27.0 0.0 5.2e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFE41464.1 - 8.1e-06 26.0 0.0 2.1e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFE41464.1 - 0.00027 20.6 0.0 0.00033 20.3 0.0 1.3 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFE41464.1 - 0.0036 16.7 0.0 0.0044 16.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region mRNA_decap_C PF16741.5 EFE41464.1 - 0.13 11.6 0.2 0.78 9.1 0.1 2.0 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus Metallophos PF00149.28 EFE41465.1 - 3.6e-32 112.5 0.0 4.9e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFE41465.1 - 1.2e-22 80.1 2.6 1.5e-22 79.7 1.7 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain GEN1_C PF18380.1 EFE41466.1 - 0.56 11.1 9.7 0.58 11.1 9.7 1.0 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain FAM176 PF14851.6 EFE41466.1 - 1.9 8.1 10.4 2.3 7.9 10.4 1.1 1 0 0 1 1 1 0 FAM176 family Paf1 PF03985.13 EFE41466.1 - 4.3 6.2 18.1 4.5 6.2 18.1 1.0 1 0 0 1 1 1 0 Paf1 YqfQ PF14181.6 EFE41466.1 - 4.3 7.5 11.1 4.9 7.3 11.1 1.0 1 0 0 1 1 1 0 YqfQ-like protein AIF_C PF14721.6 EFE41466.1 - 5.1 7.5 7.8 5.8 7.3 7.8 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RNA_polI_A34 PF08208.11 EFE41466.1 - 7.2 6.6 18.8 7.4 6.6 18.8 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 LRR_8 PF13855.6 EFE41467.1 - 1.3e-12 47.2 20.4 1.8e-07 30.8 3.6 4.4 3 1 3 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 EFE41467.1 - 1.7e-11 44.1 8.6 0.00034 20.9 0.5 4.7 3 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFE41467.1 - 2.4e-07 30.4 7.9 2.2 9.2 0.0 6.9 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.6 EFE41467.1 - 2.5e-07 30.2 11.3 0.94 9.7 0.1 6.0 6 0 0 6 6 6 3 Leucine Rich repeat LRR_9 PF14580.6 EFE41467.1 - 0.045 13.2 0.3 0.55 9.7 0.1 2.3 1 1 1 2 2 2 0 Leucine-rich repeat DUF3336 PF11815.8 EFE41470.1 - 2.8e-46 156.7 1.7 4.2e-46 156.1 1.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EFE41470.1 - 7.4e-19 68.7 1.4 2.3e-18 67.1 0.1 2.6 3 1 0 3 3 3 1 Patatin-like phospholipase FA_desaturase PF00487.24 EFE41470.1 - 0.0005 20.0 0.3 0.0015 18.5 0.0 1.8 2 0 0 2 2 2 1 Fatty acid desaturase TPR_19 PF14559.6 EFE41471.1 - 2.3e-15 56.9 15.5 0.0013 19.2 0.1 7.6 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFE41471.1 - 2.3e-13 49.6 7.6 0.00049 19.7 0.1 6.0 6 0 0 6 6 6 4 TPR repeat TPR_17 PF13431.6 EFE41471.1 - 2.7e-11 43.0 7.5 0.0019 18.5 0.1 7.3 8 0 0 8 8 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFE41471.1 - 9.2e-10 39.0 4.0 0.0002 22.0 0.3 5.0 3 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFE41471.1 - 2.3e-09 37.3 11.4 3.2 8.8 0.0 8.4 6 2 3 9 9 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFE41471.1 - 4.2e-08 32.7 23.3 0.11 12.7 0.4 9.4 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFE41471.1 - 2.1e-05 24.1 26.6 0.66 9.9 0.0 8.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFE41471.1 - 0.00012 22.0 22.3 0.46 10.8 0.6 7.8 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE41471.1 - 0.00036 20.8 18.7 1.7 9.0 0.1 7.1 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFE41471.1 - 0.00037 20.6 6.7 0.0099 16.0 0.0 4.6 3 1 2 5 5 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE41471.1 - 0.0076 16.4 18.9 0.027 14.7 0.1 5.9 7 0 0 7 7 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFE41471.1 - 0.0083 16.1 8.4 6.4 7.0 0.0 6.4 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFE41471.1 - 0.01 15.7 6.6 0.9 9.5 0.2 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 EFE41471.1 - 0.019 14.2 5.3 2.9 7.0 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFE41471.1 - 0.025 15.2 4.0 1.1 10.1 0.2 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat BTAD PF03704.17 EFE41471.1 - 0.03 14.7 0.9 0.4 11.1 0.1 2.6 1 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_20 PF14561.6 EFE41471.1 - 0.034 14.5 2.0 3.1 8.2 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFE41471.1 - 0.04 13.3 1.8 5.3 6.3 0.2 3.9 4 0 0 4 4 4 0 MalT-like TPR region ChAPs PF09295.10 EFE41471.1 - 0.046 12.7 0.0 0.085 11.8 0.0 1.3 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF2989 PF11207.8 EFE41471.1 - 0.29 10.9 3.0 7.2 6.3 0.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2989) TPR_6 PF13174.6 EFE41471.1 - 2.6 8.9 14.2 12 6.8 0.1 6.1 6 0 0 6 6 4 0 Tetratricopeptide repeat ADH_N PF08240.12 EFE41472.1 - 4.4e-23 81.2 0.6 7.1e-23 80.6 0.6 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFE41472.1 - 1.6e-15 57.2 0.0 2.7e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFE41472.1 - 3.7e-06 28.0 0.0 5.9e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EFE41472.1 - 0.017 14.4 0.1 0.029 13.7 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Nucleopor_Nup85 PF07575.13 EFE41474.1 - 1.4e-20 73.5 0.1 1.3e-15 57.1 0.0 2.4 2 1 0 2 2 2 2 Nup85 Nucleoporin TIG PF01833.24 EFE41475.1 - 0.73 9.9 6.0 0.13 12.3 1.3 2.3 2 0 0 2 2 2 0 IPT/TIG domain Trp_syntA PF00290.20 EFE41476.1 - 4.6e-91 304.2 0.0 8.5e-91 303.4 0.0 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 EFE41476.1 - 1.4e-47 162.6 2.3 2.2e-47 161.9 2.3 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Adeno_E3_CR2 PF02439.15 EFE41477.1 - 0.04 13.7 0.0 0.07 12.9 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Rubella_E2 PF05749.11 EFE41477.1 - 0.06 12.8 2.9 0.08 12.4 2.9 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 Gram_pos_anchor PF00746.21 EFE41477.1 - 0.062 13.3 0.4 0.11 12.4 0.4 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Amnionless PF14828.6 EFE41477.1 - 0.18 10.6 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Amnionless ATP-synt_ab PF00006.25 EFE41478.1 - 4.8e-68 229.0 0.0 6.3e-68 228.6 0.0 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Peptidase_S10 PF00450.22 EFE41479.1 - 1e-70 239.3 0.0 2e-70 238.3 0.0 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase GCK PF07802.11 EFE41479.1 - 0.062 13.7 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 GCK domain F-box PF00646.33 EFE41480.1 - 0.0023 17.8 0.1 0.005 16.7 0.1 1.5 1 0 0 1 1 1 1 F-box domain Usp PF00582.26 EFE41481.1 - 1e-20 74.7 5.3 1.3e-14 54.9 0.4 2.9 3 0 0 3 3 3 2 Universal stress protein family CDC45 PF02724.14 EFE41481.1 - 0.18 10.1 4.8 0.34 9.2 4.8 1.3 1 0 0 1 1 1 0 CDC45-like protein DnaJ PF00226.31 EFE41482.1 - 5.8e-22 77.6 2.0 5.8e-22 77.6 2.0 2.2 2 0 0 2 2 2 1 DnaJ domain BEN PF10523.9 EFE41483.1 - 0.09 13.0 0.1 7.4 6.9 0.0 3.0 3 0 0 3 3 3 0 BEN domain Pkinase PF00069.25 EFE41485.1 - 1.3e-57 195.2 0.0 4.1e-57 193.5 0.0 1.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41485.1 - 1.9e-32 112.6 0.5 1.5e-31 109.7 0.0 2.4 3 0 0 3 3 3 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFE41485.1 - 0.00084 18.4 0.0 0.0018 17.3 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EFE41485.1 - 0.11 11.5 0.9 0.15 11.0 0.0 1.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase LIM_bind PF01803.16 EFE41486.1 - 1.1e-61 208.4 0.0 1.1e-61 208.4 0.0 4.2 3 1 1 4 4 4 1 LIM-domain binding protein cobW PF02492.19 EFE41487.1 - 1.3e-25 90.0 0.0 1.5e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EFE41487.1 - 0.0014 17.6 0.1 0.0017 17.4 0.1 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB BING4CT PF08149.11 EFE41488.1 - 3.2e-39 132.6 0.0 2.9e-35 119.9 0.0 3.0 3 0 0 3 3 3 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EFE41488.1 - 7.3e-09 35.8 0.2 0.98 9.8 0.0 5.7 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFE41488.1 - 5.1e-05 24.0 2.1 0.47 11.4 0.0 4.5 5 1 1 6 6 6 2 WD domain, G-beta repeat DUF4427 PF14468.6 EFE41488.1 - 0.035 14.2 0.3 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4427) CHASE3 PF05227.13 EFE41488.1 - 8.7 6.2 12.0 0.15 11.9 3.8 2.1 2 0 0 2 2 2 0 CHASE3 domain RIBIOP_C PF04950.12 EFE41489.1 - 5e-109 364.2 0.0 1.4e-108 362.8 0.0 1.8 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EFE41489.1 - 1.4e-23 82.8 0.0 3.1e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 AARP2CN (NUC121) domain HlyIII PF03006.20 EFE41490.1 - 5e-24 85.3 9.1 6.5e-24 84.9 9.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF726 PF05277.12 EFE41491.1 - 1.1e-122 409.3 0.6 1.8e-122 408.6 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Thioesterase PF00975.20 EFE41491.1 - 0.07 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Thioesterase domain Glu-tRNAGln PF02686.15 EFE41492.1 - 4.5e-13 49.3 0.5 3.3e-12 46.5 0.5 2.1 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit DUF2390 PF09523.10 EFE41492.1 - 0.051 13.9 1.2 1.8 8.9 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2390) SNAP PF14938.6 EFE41493.1 - 3.6e-112 374.4 19.9 4.1e-112 374.2 19.9 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EFE41493.1 - 6.1e-09 36.1 8.0 0.00072 19.8 0.2 3.5 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFE41493.1 - 2.4e-05 24.1 12.0 0.68 10.2 0.1 6.2 3 1 2 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFE41493.1 - 0.006 16.7 16.7 0.52 10.7 0.1 5.8 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFE41493.1 - 0.0069 16.3 5.4 21 5.4 0.0 5.6 2 1 3 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFE41493.1 - 0.072 13.8 15.4 4.8 8.0 0.1 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFE41493.1 - 0.15 12.7 15.3 3 8.6 3.4 4.4 1 1 3 4 4 4 0 Tetratricopeptide repeat NSF PF02071.20 EFE41493.1 - 0.16 12.8 0.4 0.16 12.8 0.4 6.1 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat TPR_1 PF00515.28 EFE41493.1 - 0.2 11.5 15.2 3.1 7.8 0.9 5.4 4 1 1 5 5 5 0 Tetratricopeptide repeat CBP PF12192.8 EFE41493.1 - 0.29 11.3 0.1 0.29 11.3 0.1 2.0 2 1 0 2 2 2 0 Fungal calcium binding protein Ank_2 PF12796.7 EFE41494.1 - 0.00039 20.9 0.3 0.004 17.7 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFE41494.1 - 0.0039 17.6 0.3 12 6.8 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EFE41494.1 - 0.007 16.9 0.0 0.17 12.5 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) ClpB_D2-small PF10431.9 EFE41494.1 - 0.03 14.4 0.0 0.082 13.0 0.0 1.7 1 0 0 1 1 1 0 C-terminal, D2-small domain, of ClpB protein AAA_10 PF12846.7 EFE41494.1 - 0.053 12.4 0.0 0.093 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.6 EFE41494.1 - 0.057 13.8 0.0 0.22 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 EFE41494.1 - 0.14 11.3 0.0 0.31 10.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain DUF3632 PF12311.8 EFE41495.1 - 5.4e-34 118.1 0.8 5.4e-34 118.1 0.8 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3632) GPI-anchored PF10342.9 EFE41497.1 - 6.1e-07 30.1 7.8 6.2e-06 26.9 0.1 3.3 2 2 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family PRCC PF10253.9 EFE41497.1 - 8.1 7.2 10.6 12 6.7 10.6 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting SRP72 PF08492.12 EFE41498.1 - 3.5 8.1 12.3 0.23 11.9 5.9 1.9 2 0 0 2 2 2 0 SRP72 RNA-binding domain Casc1_N PF15927.5 EFE41499.1 - 0.26 11.0 10.6 3.6 7.2 0.0 2.3 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus CBF PF03914.17 EFE41500.1 - 1.2e-35 123.0 0.3 3.2e-35 121.7 0.3 1.8 1 0 0 1 1 1 1 CBF/Mak21 family DUF4806 PF16064.5 EFE41500.1 - 0.14 12.4 0.1 0.64 10.4 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4806) Mt_ATP-synt_B PF05405.14 EFE41501.1 - 1.9e-50 170.7 9.7 2.3e-50 170.4 9.7 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Pkinase PF00069.25 EFE41502.1 - 6.3e-21 74.9 0.0 1.8e-20 73.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41502.1 - 1.7e-09 37.3 0.0 0.00059 19.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Sel1 PF08238.12 EFE41504.1 - 6.3e-13 48.9 0.7 4.9e-06 27.0 0.9 4.0 4 0 0 4 4 4 3 Sel1 repeat TPR_6 PF13174.6 EFE41504.1 - 0.0087 16.6 2.0 0.29 11.8 0.3 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat VPS9 PF02204.18 EFE41505.1 - 2e-27 95.4 0.0 3.4e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain GIDA PF01134.22 EFE41505.1 - 0.028 13.5 0.4 0.092 11.8 0.5 1.7 1 1 0 1 1 1 0 Glucose inhibited division protein A NumbF PF06311.12 EFE41505.1 - 0.28 11.8 5.8 0.33 11.5 0.3 3.2 2 0 0 2 2 2 0 NUMB domain Lipase_3 PF01764.25 EFE41506.1 - 6.2e-06 26.1 0.0 1.3e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 EFE41506.1 - 0.029 14.1 0.3 0.37 10.5 0.0 2.2 2 0 0 2 2 2 0 PGAP1-like protein UPF0227 PF05728.12 EFE41506.1 - 0.05 13.5 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.8 EFE41506.1 - 0.15 11.3 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 MDM31_MDM32 PF08118.11 EFE41508.1 - 4.3e-244 811.1 0.1 2.7e-243 808.4 0.1 1.9 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins KH_8 PF17903.1 EFE41509.1 - 1.4e-05 25.1 0.0 2.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EFE41509.1 - 0.1 12.5 2.1 0.098 12.5 0.6 1.7 2 0 0 2 2 2 0 KH domain Proteasome PF00227.26 EFE41510.1 - 6.1e-32 110.6 0.1 1.6e-31 109.3 0.1 1.6 2 0 0 2 2 2 1 Proteasome subunit DUF974 PF06159.13 EFE41510.1 - 0.069 12.9 0.0 0.096 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF974) HCNGP PF07818.13 EFE41511.1 - 1.6e-31 108.8 0.4 3.3e-31 107.8 0.4 1.5 1 0 0 1 1 1 1 HCNGP-like protein Ketoacyl-synt_C PF02801.22 EFE41511.1 - 0.066 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain Proteasome PF00227.26 EFE41512.1 - 1.1e-16 60.9 0.0 1.3e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Lambda_Kil PF06301.11 EFE41512.1 - 0.12 12.0 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage lambda Kil protein FAA_hydrolase PF01557.18 EFE41513.1 - 7.1e-64 215.5 0.0 9.2e-64 215.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family GspH PF12019.8 EFE41513.1 - 0.13 12.7 0.2 0.22 11.9 0.2 1.4 1 0 0 1 1 1 0 Type II transport protein GspH HSP20 PF00011.21 EFE41514.1 - 4.6e-18 65.2 0.2 1.7e-12 47.4 0.0 2.4 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFE41514.1 - 2.4e-05 23.8 0.0 0.0088 15.6 0.0 2.3 2 0 0 2 2 2 2 HSP20-like domain found in ArsA Bac_rhodopsin PF01036.18 EFE41517.1 - 2.6e-36 125.3 21.3 3e-36 125.1 21.3 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein MFS_1 PF07690.16 EFE41519.1 - 7e-30 104.1 60.0 3.8e-28 98.4 40.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE41519.1 - 7.4e-08 31.7 37.1 0.00035 19.5 14.4 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter Tubulin_2 PF13809.6 EFE41519.1 - 0.13 11.4 0.6 0.19 10.9 0.6 1.1 1 0 0 1 1 1 0 Tubulin like Sulfatase PF00884.23 EFE41521.1 - 2.1e-79 267.1 0.0 2.6e-79 266.8 0.0 1.1 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 EFE41521.1 - 1.6e-05 23.7 0.0 2.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Cytomega_UL84 PF06284.11 EFE41522.1 - 0.21 10.0 0.8 0.25 9.8 0.8 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein WD40 PF00400.32 EFE41524.1 - 1.7e-16 60.3 11.7 0.00059 20.6 0.2 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE41524.1 - 1.2e-06 28.7 0.0 0.0013 19.0 0.0 3.7 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE41524.1 - 0.028 13.4 0.1 6.3 5.6 0.0 3.4 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Chi-conotoxin PF16981.5 EFE41524.1 - 0.19 12.0 0.1 0.74 10.1 0.1 2.0 1 1 0 1 1 1 0 chi-Conotoxin or t superfamily Lipase_3 PF01764.25 EFE41525.1 - 9.8e-30 103.3 0.0 1.5e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.20 EFE41525.1 - 0.00031 20.5 0.0 0.00053 19.7 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 EFE41525.1 - 0.0059 17.2 0.1 0.0095 16.6 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family GHMP_kinases_C PF08544.13 EFE41525.1 - 0.036 14.4 0.0 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 GHMP kinases C terminal Abhydrolase_5 PF12695.7 EFE41525.1 - 0.052 13.3 0.0 0.086 12.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Op_neuropeptide PF08035.11 EFE41525.1 - 0.1 12.4 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Opioids neuropeptide DUF2974 PF11187.8 EFE41525.1 - 0.14 11.6 0.0 1.7 8.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 EFE41525.1 - 0.23 10.7 0.0 0.38 10.0 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 WW PF00397.26 EFE41526.1 - 1.1e-11 44.6 0.6 2.5e-11 43.4 0.6 1.7 1 0 0 1 1 1 1 WW domain DUF4585 PF15232.6 EFE41526.1 - 0.036 14.1 0.0 0.036 14.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4585) PhoD PF09423.10 EFE41526.1 - 0.08 11.9 0.2 0.15 11.0 0.2 1.4 1 0 0 1 1 1 0 PhoD-like phosphatase Fungal_trans_2 PF11951.8 EFE41527.1 - 1.2e-22 80.2 0.9 1.1e-21 77.1 0.9 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Stm1_N PF09598.10 EFE41527.1 - 0.041 14.7 2.9 0.083 13.7 2.9 1.4 1 0 0 1 1 1 0 Stm1 Ecm29 PF13001.7 EFE41528.1 - 6.5e-154 513.3 0.1 8.5e-149 496.4 0.0 4.6 3 2 0 3 3 3 2 Proteasome stabiliser HEAT PF02985.22 EFE41528.1 - 4.9e-05 23.2 4.9 0.69 10.3 0.1 8.5 10 0 0 10 10 10 1 HEAT repeat HEAT_EZ PF13513.6 EFE41528.1 - 0.00054 20.4 4.0 0.64 10.6 0.0 6.1 5 0 0 5 5 5 1 HEAT-like repeat HEAT_2 PF13646.6 EFE41528.1 - 0.00088 19.6 6.6 6.6 7.2 0.2 6.2 5 2 0 5 5 5 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EFE41528.1 - 0.043 14.4 3.4 0.44 11.2 0.1 4.4 5 1 0 5 5 5 0 Vacuolar 14 Fab1-binding region Helicase_C PF00271.31 EFE41529.1 - 3.1e-06 27.5 0.0 6.4e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1690 PF07956.11 EFE41529.1 - 0.022 15.2 0.0 0.048 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) SNF2_N PF00176.23 EFE41530.1 - 9.7e-58 195.5 0.0 1.8e-57 194.6 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 EFE41530.1 - 0.00054 20.0 0.0 0.0051 16.8 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Frag1 PF10277.9 EFE41533.1 - 6.7e-18 65.0 6.7 7.8e-18 64.8 6.7 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF4436 PF14494.6 EFE41533.1 - 0.026 13.8 1.8 0.039 13.2 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4436) DUF3995 PF13160.6 EFE41533.1 - 0.066 13.6 0.8 0.066 13.6 0.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) DUF2070 PF09843.9 EFE41533.1 - 0.14 10.5 8.3 0.16 10.3 8.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF998 PF06197.13 EFE41533.1 - 1.7 8.2 7.4 5.2 6.6 7.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF998) PRA1 PF03208.19 EFE41534.1 - 1.2e-27 96.3 2.4 1.8e-27 95.7 2.4 1.2 1 0 0 1 1 1 1 PRA1 family protein FAM176 PF14851.6 EFE41534.1 - 0.0078 15.9 1.1 0.0078 15.9 1.1 2.6 1 1 1 2 2 2 1 FAM176 family DNA_pol_phi PF04931.13 EFE41534.1 - 6.4 4.8 19.6 8.7 4.3 19.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi MCM PF00493.23 EFE41535.1 - 7.8e-99 329.3 0.0 1.3e-98 328.6 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFE41535.1 - 2.2e-39 134.2 0.1 3.8e-39 133.4 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 EFE41535.1 - 7.3e-27 94.5 28.0 7.3e-27 94.5 28.0 1.9 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 EFE41535.1 - 6e-12 46.1 0.2 2e-11 44.4 0.2 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFE41535.1 - 1.2e-07 31.4 0.2 7.5e-06 25.5 0.0 2.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_lid PF17855.1 EFE41535.1 - 4.4e-07 30.2 0.0 1.2e-06 28.8 0.0 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_5 PF07728.14 EFE41535.1 - 5.2e-06 26.5 0.0 1e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFE41535.1 - 0.00036 20.4 0.0 0.0035 17.2 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFE41535.1 - 0.0068 16.1 0.2 0.12 12.1 0.2 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.6 EFE41535.1 - 0.12 12.1 0.4 0.25 11.0 0.4 1.5 1 0 0 1 1 1 0 AAA domain zf-UBR PF02207.20 EFE41536.1 - 4.6e-14 52.3 4.1 4.6e-14 52.3 4.1 3.2 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) Sugar_tr PF00083.24 EFE41537.1 - 2.1e-30 106.0 13.0 8e-24 84.3 0.4 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFE41537.1 - 1.2e-15 57.3 37.4 2.9e-14 52.8 30.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PEPCK_ATP PF01293.20 EFE41538.1 - 1.2e-216 719.8 0.0 1.6e-216 719.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase Aminotran_1_2 PF00155.21 EFE41539.1 - 4.1e-39 134.8 0.0 5.5e-39 134.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II TetR_C_14 PF17754.1 EFE41539.1 - 0.21 11.5 0.0 0.44 10.5 0.0 1.5 1 0 0 1 1 1 0 MftR C-terminal domain RPN7 PF10602.9 EFE41540.1 - 6.1e-55 185.6 0.4 1.3e-54 184.6 0.4 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EFE41540.1 - 1.2e-11 45.1 0.0 2.1e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 PCI domain DUF2654 PF10849.8 EFE41540.1 - 0.035 14.3 0.3 0.07 13.3 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2654) TPR_7 PF13176.6 EFE41540.1 - 0.16 12.0 1.0 0.59 10.3 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat MIS13 PF08202.11 EFE41541.1 - 3.2e-29 102.2 10.0 3.2e-29 102.2 10.0 3.5 2 1 0 2 2 2 1 Mis12-Mtw1 protein family DivIC PF04977.15 EFE41541.1 - 0.018 14.8 0.1 0.052 13.3 0.1 1.7 1 0 0 1 1 1 0 Septum formation initiator Sugar_tr PF00083.24 EFE41542.1 - 1.8e-80 271.0 24.4 4.3e-80 269.8 24.4 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE41542.1 - 4.4e-31 108.1 47.0 5.7e-20 71.5 21.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EFE41542.1 - 1e-05 25.0 5.8 1e-05 25.0 5.8 2.9 2 1 0 3 3 3 2 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 EFE41542.1 - 0.003 15.9 1.5 0.003 15.9 1.5 2.1 2 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family AMP-binding PF00501.28 EFE41543.1 - 5.6e-74 249.2 0.0 8.8e-74 248.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.26 EFE41543.1 - 5.8e-62 209.5 0.1 4.8e-61 206.5 0.1 2.2 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Condensation PF00668.20 EFE41543.1 - 1.1e-55 189.1 0.0 1.8e-55 188.5 0.0 1.2 1 0 0 1 1 1 1 Condensation domain KR PF08659.10 EFE41543.1 - 2.3e-52 177.5 0.1 1.3e-50 171.8 0.0 2.4 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EFE41543.1 - 4.1e-49 167.4 0.0 6.5e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EFE41543.1 - 4.2e-41 141.5 0.0 8.1e-41 140.5 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFE41543.1 - 1.1e-31 109.3 0.0 3.9e-31 107.5 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EFE41543.1 - 1.3e-19 70.7 0.0 7.8e-18 65.1 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain NAD_binding_4 PF07993.12 EFE41543.1 - 4.2e-18 65.5 0.0 9.3e-18 64.3 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein KAsynt_C_assoc PF16197.5 EFE41543.1 - 2.9e-15 56.7 0.0 3.8e-14 53.1 0.0 2.5 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EFE41543.1 - 3.1e-15 56.3 1.2 1e-06 29.0 0.1 3.0 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_25 PF13649.6 EFE41543.1 - 2.5e-12 47.4 0.0 1.8e-11 44.6 0.0 2.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE41543.1 - 3.1e-09 36.9 0.0 7.7e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE41543.1 - 4.2e-09 36.9 0.0 5.9e-08 33.3 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE41543.1 - 7.3e-09 35.6 0.0 5.6e-08 32.7 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.25 EFE41543.1 - 5e-08 32.6 0.0 1.5e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase Thiolase_N PF00108.23 EFE41543.1 - 2.3e-06 27.2 0.1 4.7e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 EFE41543.1 - 3.7e-06 26.4 0.0 1.5e-05 24.5 0.0 1.9 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family Epimerase PF01370.21 EFE41543.1 - 0.00014 21.5 0.0 0.17 11.3 0.0 2.5 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family SAT PF16073.5 EFE41543.1 - 0.001 18.8 0.2 0.0024 17.7 0.2 1.6 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis GDP_Man_Dehyd PF16363.5 EFE41543.1 - 0.0027 17.2 0.0 0.024 14.0 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Methyltransf_33 PF10017.9 EFE41543.1 - 0.0094 15.1 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_16 PF10294.9 EFE41543.1 - 0.012 15.4 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase AMP-binding_C PF13193.6 EFE41543.1 - 0.19 12.7 0.0 0.82 10.7 0.0 2.2 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain UvdE PF03851.14 EFE41544.1 - 4.4e-110 367.3 0.0 5.6e-110 366.9 0.0 1.1 1 0 0 1 1 1 1 UV-endonuclease UvdE Como_LCP PF02247.16 EFE41544.1 - 0.21 10.2 0.0 0.28 9.7 0.0 1.1 1 0 0 1 1 1 0 Large coat protein ADH_zinc_N PF00107.26 EFE41546.1 - 6.4e-11 42.3 0.0 1.4e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE41546.1 - 5.2e-06 26.3 1.6 1.7e-05 24.6 1.5 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFE41546.1 - 0.015 16.4 0.0 0.032 15.3 0.0 1.6 1 1 0 1 1 1 0 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EFE41546.1 - 0.087 12.7 0.2 4.2 7.3 0.3 2.3 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase Pkinase PF00069.25 EFE41548.1 - 1.9e-56 191.4 0.0 2.3e-56 191.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41548.1 - 1e-25 90.5 0.0 1.5e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFE41548.1 - 0.0048 15.9 0.1 0.0068 15.4 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain GFO_IDH_MocA PF01408.22 EFE41549.1 - 3.3e-10 40.8 0.5 1.8e-09 38.5 0.5 2.1 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DHDPS PF00701.22 EFE41550.1 - 2.3e-33 115.1 0.0 9.5e-32 109.9 0.0 2.0 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family ADH_zinc_N PF00107.26 EFE41551.1 - 1.2e-15 57.7 0.0 2.3e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE41551.1 - 2.1e-12 46.9 0.6 4.1e-12 45.9 0.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.19 EFE41551.1 - 0.00015 21.2 0.3 0.00027 20.4 0.3 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EFE41551.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA WD40 PF00400.32 EFE41552.1 - 3.1e-23 81.6 12.4 0.0014 19.4 0.1 7.1 6 1 0 6 6 6 5 WD domain, G-beta repeat F-box-like PF12937.7 EFE41552.1 - 3.9e-09 36.2 0.1 8.2e-09 35.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like PQQ PF01011.21 EFE41552.1 - 1.8e-05 24.4 0.0 1.5 8.9 0.0 3.9 3 0 0 3 3 3 2 PQQ enzyme repeat F-box PF00646.33 EFE41552.1 - 3.4e-05 23.6 0.1 7e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.6 EFE41552.1 - 0.00014 21.5 0.1 0.41 10.2 0.0 2.3 1 1 0 2 2 2 2 PQQ-like domain ANAPC4_WD40 PF12894.7 EFE41552.1 - 0.00068 19.9 0.2 6.8 7.1 0.0 4.3 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 EFE41552.1 - 0.083 12.8 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 F-box PALB2_WD40 PF16756.5 EFE41552.1 - 0.11 11.4 0.1 4.6 6.1 0.0 2.3 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain SelP_N PF04592.14 EFE41552.1 - 9.1 5.6 9.6 15 4.9 9.6 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ADH_zinc_N_2 PF13602.6 EFE41553.1 - 1.2e-12 49.0 0.0 1.9e-12 48.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFE41553.1 - 2.4e-08 34.0 0.0 4.7e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase EB1 PF03271.17 EFE41554.1 - 2.5e-17 62.8 0.5 4.2e-17 62.1 0.5 1.4 1 0 0 1 1 1 1 EB1-like C-terminal motif Herpes_UL6 PF01763.16 EFE41554.1 - 0.00057 18.5 0.0 0.00067 18.3 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus UL6 like Adeno_E3_CR2 PF02439.15 EFE41555.1 - 0.11 12.3 0.5 0.21 11.4 0.5 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Macoilin PF09726.9 EFE41555.1 - 1.7 7.1 11.8 2.3 6.7 11.8 1.2 1 0 0 1 1 1 0 Macoilin family GP67 PF17634.2 EFE41557.1 - 0.0045 17.4 0.9 0.0065 16.9 0.9 1.3 1 0 0 1 1 1 1 Gene product 67 Glutaredoxin PF00462.24 EFE41558.1 - 9.9e-09 35.3 0.0 1.3e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Chalcone_2 PF16035.5 EFE41559.1 - 1.4e-73 247.0 0.0 2.4e-73 246.3 0.0 1.4 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EFE41559.1 - 0.0072 16.5 0.0 0.023 14.8 0.0 1.8 1 0 0 1 1 1 1 Chalcone isomerase-like GTP_EFTU PF00009.27 EFE41560.1 - 1.3e-54 184.7 0.0 2e-54 184.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFE41560.1 - 4.7e-42 142.8 0.0 1e-41 141.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFE41560.1 - 5.7e-14 52.3 1.3 1.7e-13 50.7 1.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFE41560.1 - 0.0012 18.9 0.2 0.013 15.6 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EFE41560.1 - 0.025 14.5 1.1 0.072 13.0 1.1 1.8 1 0 0 1 1 1 0 Elongation factor Tu domain 4 AAA_29 PF13555.6 EFE41560.1 - 0.12 12.1 0.6 12 5.7 0.1 3.0 3 0 0 3 3 3 0 P-loop containing region of AAA domain NAD_binding_10 PF13460.6 EFE41561.1 - 2.3e-08 34.2 0.0 4.6e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFE41561.1 - 1.8e-05 24.4 0.0 5.3e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EFE41561.1 - 0.016 14.7 0.0 0.32 10.4 0.0 2.3 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EFE41561.1 - 0.081 13.2 0.0 0.18 12.0 0.0 1.6 1 1 0 1 1 1 0 TrkA-N domain F420_oxidored PF03807.17 EFE41561.1 - 0.15 12.6 0.0 0.76 10.4 0.0 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent PH_4 PF15404.6 EFE41562.1 - 3.9e-42 144.1 3.7 1.3e-41 142.4 1.5 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain Spo7_2_N PF15407.6 EFE41562.1 - 1.7e-17 62.8 0.1 6.4e-17 60.9 0.1 2.0 1 1 0 1 1 1 1 Sporulation protein family 7 PH PF00169.29 EFE41562.1 - 3.7e-08 33.8 1.7 0.79 10.3 0.1 4.8 4 0 0 4 4 4 3 PH domain PH_6 PF15406.6 EFE41562.1 - 0.0017 18.6 0.2 0.16 12.3 0.1 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 EFE41562.1 - 0.0021 18.4 0.1 0.032 14.6 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 EFE41562.1 - 0.14 11.9 0.5 9 6.1 0.0 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain GLTP PF08718.11 EFE41563.1 - 1.9e-47 161.3 0.1 2.4e-47 160.9 0.1 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) AA_permease_2 PF13520.6 EFE41564.1 - 2.4e-63 214.4 50.6 3e-63 214.1 50.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE41564.1 - 5.7e-21 74.7 37.3 8.6e-21 74.1 37.3 1.2 1 0 0 1 1 1 1 Amino acid permease E1-E2_ATPase PF00122.20 EFE41566.1 - 3.6e-20 72.2 0.0 8.7e-20 71.0 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFE41566.1 - 4.3e-13 50.0 1.9 3e-06 27.7 3.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFE41566.1 - 0.0031 17.3 0.2 0.026 14.3 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE41566.1 - 0.0048 17.0 0.0 0.014 15.5 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) S6PP PF05116.13 EFE41566.1 - 0.09 12.3 0.1 0.27 10.7 0.0 1.7 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase FYVE PF01363.21 EFE41567.1 - 4.4e-20 71.6 13.2 4.4e-15 55.6 2.4 2.9 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 EFE41567.1 - 1.3e-17 63.3 0.6 3e-17 62.1 0.6 1.7 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-AN1 PF01428.16 EFE41567.1 - 0.012 15.7 6.0 0.012 15.7 6.0 3.3 2 1 1 3 3 3 0 AN1-like Zinc finger YqaH PF17448.2 EFE41567.1 - 0.012 15.9 0.2 0.033 14.5 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized YqaH-like TMF_TATA_bd PF12325.8 EFE41567.1 - 0.046 13.9 2.5 0.057 13.6 0.5 2.1 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Seryl_tRNA_N PF02403.22 EFE41567.1 - 0.059 13.6 1.4 0.18 12.0 1.4 1.8 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Prok-RING_4 PF14447.6 EFE41567.1 - 0.31 10.9 0.1 0.31 10.9 0.1 4.2 4 1 1 5 5 5 0 Prokaryotic RING finger family 4 zf-Di19 PF05605.12 EFE41567.1 - 0.48 10.8 11.4 4.6 7.6 3.0 3.5 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding FYVE_2 PF02318.16 EFE41567.1 - 0.62 10.3 12.1 0.09 13.0 2.6 3.3 3 0 0 3 3 3 0 FYVE-type zinc finger C6_DPF PF10170.9 EFE41567.1 - 1.2 9.6 9.2 0.048 14.0 1.4 2.4 2 0 0 2 2 2 0 Cysteine-rich domain Siva PF05458.12 EFE41567.1 - 1.4 8.5 12.1 0.54 9.9 1.2 3.0 3 0 0 3 3 3 0 Cd27 binding protein (Siva) UBZ_FAAP20 PF15750.5 EFE41567.1 - 4.1 7.4 6.5 2.8 8.0 0.3 3.4 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger IBR PF01485.21 EFE41567.1 - 5.6 7.3 16.6 0.51 10.6 3.3 3.0 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain PKD_channel PF08016.12 EFE41568.1 - 1.1e-07 31.0 19.4 4.2e-07 29.0 15.4 2.6 2 1 0 2 2 2 1 Polycystin cation channel CAML PF14963.6 EFE41568.1 - 0.64 10.1 2.5 1.5 8.9 2.5 1.6 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand EIF_2_alpha PF07541.12 EFE41569.1 - 2.2e-36 124.4 0.0 5e-36 123.3 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EFE41569.1 - 1.7e-13 50.7 0.9 3.7e-13 49.6 0.9 1.5 1 0 0 1 1 1 1 S1 RNA binding domain SLIDE PF09111.10 EFE41569.1 - 0.17 11.9 0.7 1.2 9.2 0.0 2.7 3 1 1 4 4 4 0 SLIDE Sulfate_transp PF00916.20 EFE41570.1 - 3.4e-76 256.5 12.7 4.6e-76 256.0 12.7 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EFE41570.1 - 4.8e-16 58.5 0.0 7.8e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 EFE41570.1 - 0.0081 16.5 0.0 0.019 15.3 0.0 1.7 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EFE41570.1 - 6.1 7.3 16.7 0.086 13.2 5.4 2.8 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily CENP-L PF13092.6 EFE41571.1 - 3.3e-52 177.0 0.0 4.4e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 Cue1_U7BR PF18499.1 EFE41571.1 - 0.15 12.1 0.1 0.33 11.0 0.1 1.5 1 0 0 1 1 1 0 Ubc7p-binding region of Cue1 DUF3638 PF12340.8 EFE41572.1 - 2.8e-90 301.6 0.0 5.2e-90 300.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EFE41572.1 - 1.3e-14 53.3 0.0 3.8e-14 51.8 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) DUF1690 PF07956.11 EFE41572.1 - 1.8 9.0 6.0 0.42 11.0 0.5 2.7 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) ABC_membrane PF00664.23 EFE41573.1 - 4e-40 138.2 11.8 5.5e-40 137.7 11.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFE41573.1 - 5.5e-34 117.6 0.0 1e-33 116.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFE41573.1 - 1.6e-05 24.5 0.0 0.0026 17.2 0.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFE41573.1 - 0.00012 22.4 0.0 0.00041 20.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFE41573.1 - 0.00017 22.0 0.0 0.0004 20.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EFE41573.1 - 0.00061 19.7 0.1 0.011 15.6 0.0 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EFE41573.1 - 0.01 15.9 0.1 0.15 12.1 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFE41573.1 - 0.016 14.9 0.1 0.036 13.8 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 EFE41573.1 - 0.017 14.9 0.5 0.032 14.0 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EFE41573.1 - 0.019 15.5 0.0 0.054 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFE41573.1 - 0.021 14.9 0.2 0.35 10.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFE41573.1 - 0.023 14.6 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain G-alpha PF00503.20 EFE41573.1 - 0.029 13.5 0.0 0.087 12.0 0.0 1.8 2 0 0 2 2 2 0 G-protein alpha subunit GPAT_N PF14829.6 EFE41573.1 - 0.031 14.3 0.0 7.7 6.6 0.0 2.8 3 0 0 3 3 3 0 Glycerol-3-phosphate acyltransferase N-terminal AAA_18 PF13238.6 EFE41573.1 - 0.031 14.8 0.0 0.095 13.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFE41573.1 - 0.033 14.1 0.0 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA PF00004.29 EFE41573.1 - 0.049 14.1 0.0 0.4 11.1 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rop-like PF05082.13 EFE41573.1 - 0.049 13.5 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 Rop-like AAA_24 PF13479.6 EFE41573.1 - 0.049 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFE41573.1 - 0.054 13.1 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFE41573.1 - 0.058 13.6 0.0 0.21 11.8 0.0 2.0 2 0 0 2 2 1 0 AAA domain ATP-synt_ab PF00006.25 EFE41573.1 - 0.061 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Cytidylate_kin PF02224.18 EFE41573.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase IstB_IS21 PF01695.17 EFE41573.1 - 0.3 10.8 1.8 12 5.6 0.0 3.0 4 0 0 4 4 4 0 IstB-like ATP binding protein DUF2013 PF09431.10 EFE41574.1 - 3.8e-51 172.9 1.8 7.9e-51 171.8 1.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) Glyco_hydro_17 PF00332.18 EFE41575.1 - 3.3e-06 26.9 3.0 1e-05 25.3 0.3 2.3 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 Aminotran_1_2 PF00155.21 EFE41576.1 - 3.6e-34 118.5 0.0 4.6e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFE41576.1 - 0.063 11.8 0.0 0.34 9.4 0.0 1.9 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Glucan_synthase PF02364.15 EFE41577.1 - 0 1370.0 0.0 0 1369.5 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EFE41577.1 - 1.8e-43 148.0 0.2 5.9e-43 146.3 0.2 2.0 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 TRAP-gamma PF07074.12 EFE41578.1 - 1.7 8.2 4.5 2 7.9 4.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) PBP_sp32 PF07222.12 EFE41578.1 - 2.2 7.7 11.0 3 7.2 11.0 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4746 PF15928.5 EFE41578.1 - 5 6.5 12.7 5.6 6.3 12.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Glyco_hydro_72 PF03198.14 EFE41580.1 - 1.9e-131 438.0 7.8 2.3e-131 437.7 7.8 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EFE41580.1 - 9.2e-26 90.3 3.8 3e-25 88.7 3.8 2.0 1 0 0 1 1 1 1 X8 domain Glyco_hydro_2_C PF02836.17 EFE41580.1 - 0.00061 19.0 2.7 0.0029 16.8 2.7 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 EFE41580.1 - 0.0007 19.1 0.6 0.0089 15.5 0.6 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_114 PF03537.13 EFE41580.1 - 0.077 12.3 3.5 5.5 6.2 1.4 2.2 1 1 0 2 2 2 0 Glycoside-hydrolase family GH114 SprT-like PF10263.9 EFE41581.1 - 6.9e-36 122.5 2.0 2.6e-35 120.7 0.2 2.2 2 0 0 2 2 2 1 SprT-like family Zn_ribbon_SprT PF17283.2 EFE41581.1 - 4.1e-06 26.6 6.7 4.1e-06 26.6 6.7 2.4 2 0 0 2 2 2 1 SprT-like zinc ribbon domain Mog1 PF04603.12 EFE41582.1 - 4.2e-27 95.2 0.0 1.1e-26 93.8 0.0 1.7 1 1 0 1 1 1 1 Ran-interacting Mog1 protein Herpes_UL37_1 PF03970.13 EFE41582.1 - 0.051 12.8 0.0 4.4 6.4 0.0 2.1 2 0 0 2 2 2 0 Herpesvirus UL37 tegument protein PAD_porph PF04371.15 EFE41582.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Porphyromonas-type peptidyl-arginine deiminase NYN PF01936.18 EFE41583.1 - 0.00032 21.2 0.0 0.0034 17.9 0.0 2.3 1 1 0 1 1 1 1 NYN domain HSP9_HSP12 PF04119.12 EFE41584.1 - 1.7e-26 92.4 5.1 1.7e-26 92.4 5.1 1.8 2 0 0 2 2 2 1 Heat shock protein 9/12 Chlorosome_CsmC PF11098.8 EFE41584.1 - 0.015 15.3 0.2 0.018 15.0 0.2 1.1 1 0 0 1 1 1 0 Chlorosome envelope protein C ISG65-75 PF11727.8 EFE41584.1 - 0.15 11.3 1.0 0.18 11.0 1.0 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein COG6 PF06419.11 EFE41585.1 - 7.5e-209 695.0 0.4 8.5e-209 694.9 0.4 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Transcrip_act PF04949.13 EFE41585.1 - 0.0044 16.9 0.1 0.018 14.9 0.1 2.2 1 0 0 1 1 1 1 Transcriptional activator HeLo PF14479.6 EFE41585.1 - 0.021 14.7 0.4 1.3 8.8 0.0 3.1 3 0 0 3 3 3 0 Prion-inhibition and propagation NIF3 PF01784.18 EFE41586.1 - 7.5e-29 101.1 0.0 4.7e-23 82.1 0.0 2.7 1 1 1 2 2 2 2 NIF3 (NGG1p interacting factor 3) Redoxin PF08534.10 EFE41588.1 - 5.3e-31 107.3 0.0 6.2e-31 107.1 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EFE41588.1 - 2.9e-07 30.4 0.0 3.8e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family V_ATPase_I PF01496.19 EFE41590.1 - 0.02 12.9 2.8 0.03 12.2 2.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPR3 PF03666.13 EFE41590.1 - 0.026 13.3 8.3 0.035 12.9 8.3 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 OATP PF03137.20 EFE41590.1 - 0.24 9.6 2.3 0.43 8.8 2.3 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DDHD PF02862.17 EFE41590.1 - 0.36 11.0 2.8 0.46 10.6 2.8 1.2 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 EFE41590.1 - 0.64 8.2 10.5 0.79 7.9 10.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 EFE41590.1 - 1 9.7 19.1 1.4 9.2 19.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 MDM10 PF12519.8 EFE41590.1 - 1.1 8.1 7.5 1.5 7.6 7.5 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MCM_bind PF09739.9 EFE41590.1 - 3.7 5.9 9.4 5 5.4 9.4 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF2207 PF09972.9 EFE41590.1 - 7.9 5.1 9.9 21 3.7 9.9 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) HSF_DNA-bind PF00447.17 EFE41591.1 - 3.1e-06 27.7 0.2 1.3e-05 25.7 0.2 2.1 1 1 0 1 1 1 1 HSF-type DNA-binding DUF16 PF01519.16 EFE41591.1 - 1.9 9.0 6.0 0.89 10.1 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF3446 PF11928.8 EFE41591.1 - 2.6 8.4 8.3 0.18 12.1 0.9 2.5 1 1 1 2 2 2 0 Early growth response N-terminal domain MDFI PF15316.6 EFE41591.1 - 2.9 8.0 5.6 4.8 7.2 0.5 2.4 2 1 0 2 2 2 0 MyoD family inhibitor DUF1115 PF06544.12 EFE41592.1 - 0.031 14.4 0.3 0.069 13.2 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) DUF3357 PF11837.8 EFE41592.1 - 0.066 13.7 1.3 0.14 12.6 0.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) CREPT PF16566.5 EFE41593.1 - 0.04 14.1 9.2 0.054 13.7 9.2 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Roughex PF06020.11 EFE41593.1 - 0.1 11.6 8.5 0.4 9.7 8.8 1.7 2 0 0 2 2 2 0 Drosophila roughex protein Med3 PF11593.8 EFE41593.1 - 0.12 11.5 17.3 0.15 11.3 17.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4175 PF13779.6 EFE41593.1 - 0.2 9.5 16.6 0.22 9.4 16.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Spt20 PF12090.8 EFE41593.1 - 0.26 10.8 21.4 0.41 10.2 21.4 1.3 1 0 0 1 1 1 0 Spt20 family EPL1 PF10513.9 EFE41593.1 - 0.55 10.6 8.8 0.73 10.2 8.8 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Lin-8 PF03353.15 EFE41593.1 - 0.76 9.3 10.8 0.82 9.2 10.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 EFE41593.1 - 1.1 7.9 8.7 1.3 7.7 8.7 1.1 1 0 0 1 1 1 0 Presenilin UPF0560 PF10577.9 EFE41593.1 - 1.3 7.4 12.3 1.5 7.2 12.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 CPSF100_C PF13299.6 EFE41593.1 - 1.6 8.9 6.7 2.3 8.4 6.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Ndc1_Nup PF09531.10 EFE41593.1 - 2.9 6.5 11.7 3.2 6.4 11.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hydin_ADK PF17213.3 EFE41593.1 - 3.8 7.7 9.8 1.8 8.8 7.7 1.4 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain RR_TM4-6 PF06459.12 EFE41593.1 - 3.9 7.2 12.1 5.4 6.8 12.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EMC3_TMCO1 PF01956.16 EFE41593.1 - 4.4 7.0 4.8 5.5 6.7 4.8 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like OmpH PF03938.14 EFE41593.1 - 5.1 7.4 19.6 7.1 7.0 19.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) RSB_motif PF16294.5 EFE41593.1 - 5.5 7.3 15.1 8.4 6.7 15.1 1.2 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif Neur_chan_memb PF02932.16 EFE41593.1 - 5.7 6.9 5.8 7 6.6 5.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 EFE41593.1 - 8.3 4.5 20.5 8.9 4.4 20.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sin3a_C PF16879.5 EFE41594.1 - 1.2e-77 261.5 3.6 2e-77 260.7 0.1 2.9 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein PAH PF02671.21 EFE41594.1 - 1.7e-43 146.5 1.1 7.5e-18 64.4 0.0 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EFE41594.1 - 2.7e-40 136.4 0.0 7.3e-40 135.0 0.0 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor TSP_NTD PF17804.1 EFE41594.1 - 0.031 14.5 0.4 0.15 12.3 0.4 2.1 1 0 0 1 1 1 0 Tail specific protease N-terminal domain Enkurin PF13864.6 EFE41594.1 - 0.17 12.3 1.4 0.97 9.9 0.0 3.0 2 0 0 2 2 2 0 Calmodulin-binding Glyco_hydro_17 PF00332.18 EFE41595.1 - 0.0078 15.8 0.1 0.042 13.4 0.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 MFS_1 PF07690.16 EFE41597.1 - 8.6e-33 113.7 54.7 6.9e-31 107.4 55.3 3.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE41597.1 - 1.4e-11 43.6 25.0 2.4e-11 42.8 25.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFE41597.1 - 2.2e-10 40.0 7.5 2.2e-10 40.0 7.5 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EFE41597.1 - 0.012 14.0 8.3 0.08 11.2 2.3 2.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Sel1 PF08238.12 EFE41598.1 - 1.8e-38 130.1 31.1 1.6e-05 25.4 0.1 7.5 7 0 0 7 7 7 7 Sel1 repeat Cwf_Cwc_15 PF04889.12 EFE41598.1 - 0.0072 16.1 0.8 0.0072 16.1 0.8 2.1 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein TPR_6 PF13174.6 EFE41598.1 - 0.032 14.9 5.7 2.9 8.7 0.3 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Chitin_synth_2 PF03142.15 EFE41599.1 - 8.5e-290 961.8 0.1 8.5e-290 961.8 0.1 1.4 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EFE41599.1 - 2.2e-13 50.5 1.7 7.2e-13 48.9 1.7 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFE41599.1 - 2.6e-09 37.3 0.0 6.8e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EFE41599.1 - 0.00012 21.7 0.1 0.0017 17.9 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EFE41599.1 - 0.0089 15.9 0.1 0.079 12.8 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 2 OrfB_IS605 PF01385.19 EFE41599.1 - 0.65 10.2 2.8 1.1 9.5 0.8 2.1 2 0 0 2 2 2 0 Probable transposase Selenoprotein_S PF06936.11 EFE41599.1 - 1.8 8.3 8.6 4.2 7.1 6.9 2.1 2 0 0 2 2 2 0 Selenoprotein S (SelS) TAF8_C PF10406.9 EFE41600.1 - 0.034 14.7 0.4 0.12 12.9 0.4 2.0 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term WD40 PF00400.32 EFE41601.1 - 6.8e-05 23.6 2.3 0.018 15.9 0.1 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF123 PF01986.16 EFE41601.1 - 0.17 12.4 0.1 0.37 11.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF123 TRAPPC10 PF12584.8 EFE41602.1 - 2.2e-39 134.7 0.0 4.1e-39 133.8 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 TIG PF01833.24 EFE41603.1 - 1.7e-09 37.7 0.2 4.4e-09 36.3 0.2 1.7 1 0 0 1 1 1 1 IPT/TIG domain Ank PF00023.30 EFE41603.1 - 1.2e-08 35.0 6.2 0.0024 18.2 2.9 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EFE41603.1 - 6.2e-08 33.1 0.1 1.2e-07 32.2 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE41603.1 - 4.8e-07 30.2 0.9 2e-06 28.2 0.4 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE41603.1 - 4.8e-07 29.9 0.9 5.7e-05 23.3 0.6 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE41603.1 - 5.1e-06 26.4 0.9 0.076 13.6 0.3 2.7 2 0 0 2 2 2 2 Ankyrin repeat Bap31 PF05529.12 EFE41603.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Bap31/Bap29 transmembrane region Trypsin PF00089.26 EFE41604.1 - 1.4e-08 34.9 0.3 1.2e-07 31.8 0.3 2.1 1 1 0 2 2 2 1 Trypsin SUI1 PF01253.22 EFE41605.1 - 7.9e-19 68.0 0.0 2.1e-18 66.6 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 EFE41605.1 - 3.8e-08 33.9 0.0 2.5e-06 28.1 0.0 2.8 1 1 0 1 1 1 1 Pre-PUA-like domain CHD5 PF04420.14 EFE41606.1 - 4.6e-37 127.3 9.8 6.8e-36 123.5 9.8 2.0 1 1 0 1 1 1 1 CHD5-like protein Mito_carr PF00153.27 EFE41607.1 - 1e-62 208.0 2.7 1.9e-21 75.8 0.0 3.7 2 2 1 3 3 3 3 Mitochondrial carrier protein UCR_14kD PF02271.16 EFE41608.1 - 6e-38 128.8 1.5 2.9e-37 126.6 1.5 1.9 1 1 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit PAS_3 PF08447.12 EFE41608.1 - 0.0078 16.5 0.0 0.022 15.0 0.0 1.7 1 0 0 1 1 1 1 PAS fold HhH-GPD PF00730.25 EFE41609.1 - 8.6e-13 48.7 0.0 1.4e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein ODAPH PF15848.5 EFE41609.1 - 5.3 7.5 6.9 9.5 6.7 0.3 2.4 1 1 1 2 2 2 0 Odontogenesis associated phosphoprotein Recep_L_domain PF01030.24 EFE41610.1 - 1.9e-11 44.0 3.4 0.064 13.4 0.0 5.4 1 1 4 6 6 6 5 Receptor L domain Ecm33 PF12454.8 EFE41610.1 - 4.3e-06 26.8 5.8 0.0061 16.7 0.0 3.1 3 1 1 4 4 4 2 GPI-anchored cell wall organization protein LRR_5 PF13306.6 EFE41610.1 - 0.0049 16.8 1.6 0.23 11.4 0.4 2.7 1 1 1 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EFE41610.1 - 1.3 9.5 14.7 1.3 9.5 1.2 5.0 3 3 2 5 5 5 0 Leucine Rich repeats (2 copies) Anp1 PF03452.14 EFE41612.1 - 1.6e-97 326.0 1.1 4.6e-62 209.8 0.1 2.1 2 0 0 2 2 2 2 Anp1 ABC1 PF03109.16 EFE41613.1 - 1.8e-32 112.0 0.0 3.6e-32 111.0 0.0 1.5 1 0 0 1 1 1 1 ABC1 family FA_desaturase PF00487.24 EFE41614.1 - 8.1e-27 94.7 9.6 1.1e-26 94.2 9.6 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 EFE41614.1 - 2.1e-17 62.3 0.7 3.9e-17 61.4 0.7 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) zf-C2H2 PF00096.26 EFE41615.1 - 0.014 15.8 3.3 0.014 15.8 3.3 4.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE41615.1 - 0.015 15.7 1.2 0.015 15.7 1.2 3.4 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EFE41615.1 - 0.07 13.4 4.2 0.19 12.0 4.2 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF2614 PF11023.8 EFE41615.1 - 0.17 12.0 0.3 0.28 11.3 0.3 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain zf-C2H2_4 PF13894.6 EFE41615.1 - 2.5 9.2 20.6 0.35 11.8 2.3 4.7 4 0 0 4 4 4 0 C2H2-type zinc finger Cytochrome_C7 PF14522.6 EFE41615.1 - 3 7.9 13.4 8.7 6.4 13.2 2.0 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c Vps8 PF12816.7 EFE41616.1 - 7.4e-65 218.2 0.5 6.1e-64 215.2 0.0 2.3 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EFE41616.1 - 1.7e-08 34.5 5.9 0.00079 19.3 0.3 4.5 4 1 0 4 4 4 2 Region in Clathrin and VPS Pox_D3 PF04580.13 EFE41616.1 - 0.012 15.2 0.1 0.028 14.1 0.1 1.5 1 0 0 1 1 1 0 Chordopoxvirinae D3 protein zf-C3H2C3 PF17122.5 EFE41616.1 - 0.12 12.4 0.1 0.12 12.4 0.1 1.9 2 0 0 2 2 2 0 Zinc-finger zf-ANAPC11 PF12861.7 EFE41616.1 - 0.15 12.1 0.2 0.73 9.9 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EFE41616.1 - 0.33 11.3 1.0 1.2 9.5 0.0 2.5 3 0 0 3 3 3 0 Ring finger domain zf-HC5HC2H_2 PF13832.6 EFE41617.1 - 8.9e-24 83.8 0.8 8.9e-24 83.8 0.8 3.7 3 1 1 4 4 4 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EFE41617.1 - 4e-21 75.1 2.6 4e-21 75.1 2.6 4.1 3 1 0 3 3 3 1 PHD-like zinc-binding domain BAH PF01426.18 EFE41617.1 - 3.7e-12 46.2 0.4 1e-11 44.7 0.1 2.0 2 0 0 2 2 2 1 BAH domain PHD_2 PF13831.6 EFE41617.1 - 1.3e-08 34.2 3.3 1.3e-08 34.2 3.3 3.9 5 0 0 5 5 5 1 PHD-finger PHD PF00628.29 EFE41617.1 - 5e-07 29.5 7.5 5e-07 29.5 7.5 5.2 6 0 0 6 6 6 2 PHD-finger C1_1 PF00130.22 EFE41617.1 - 0.0087 15.9 2.4 0.0087 15.9 2.4 5.8 6 1 1 7 7 7 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE_2 PF02318.16 EFE41617.1 - 0.009 16.2 2.9 0.009 16.2 2.9 4.2 5 0 0 5 5 5 1 FYVE-type zinc finger Myb_DNA-binding PF00249.31 EFE41617.1 - 0.033 14.4 0.3 0.14 12.4 0.0 2.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain GATA PF00320.27 EFE41617.1 - 4.3 7.0 18.8 0.29 10.8 1.0 4.5 4 0 0 4 4 4 0 GATA zinc finger CDC45 PF02724.14 EFE41617.1 - 9.1 4.4 14.6 7.5 4.7 6.2 2.3 2 0 0 2 2 2 0 CDC45-like protein JAB PF01398.21 EFE41619.1 - 6.8e-14 51.9 0.0 1.3e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 EFE41619.1 - 8.4e-06 26.0 0.0 1.7e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 EFE41619.1 - 1.5e-05 24.7 0.0 3.6e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Syntaxin-6_N PF09177.11 EFE41619.1 - 0.013 16.1 0.6 0.033 14.7 0.6 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal TBCA PF02970.16 EFE41619.1 - 0.15 12.4 0.5 0.4 11.0 0.5 1.7 1 0 0 1 1 1 0 Tubulin binding cofactor A DUF573 PF04504.14 EFE41619.1 - 0.19 12.4 0.1 0.4 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF573 Allexi_40kDa PF05549.11 EFE41619.1 - 1.8 8.0 5.7 1 8.9 0.8 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein TBCC PF07986.12 EFE41620.1 - 8.4e-24 83.6 2.2 1.6e-23 82.7 2.2 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 EFE41620.1 - 7.9e-13 48.9 0.6 7.9e-13 48.9 0.6 2.3 2 0 0 2 2 2 1 Tubulin-specific chaperone C N-terminal domain Ndc1_Nup PF09531.10 EFE41620.1 - 0.054 12.2 3.1 0.065 11.9 3.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DivIVA PF05103.13 EFE41621.1 - 0.00078 19.5 21.3 0.008 16.3 6.9 3.5 2 1 1 3 3 3 2 DivIVA protein DUF4407 PF14362.6 EFE41621.1 - 0.0072 15.7 6.0 0.0072 15.7 6.0 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) HAP1_N PF04849.13 EFE41621.1 - 0.37 9.9 35.5 0.056 12.6 0.5 2.9 2 1 0 2 2 2 0 HAP1 N-terminal conserved region Fib_alpha PF08702.10 EFE41621.1 - 3 8.0 16.9 2.2 8.4 6.4 3.3 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family PET117 PF15786.5 EFE41622.1 - 6.7e-09 35.9 6.0 7.9e-09 35.7 6.0 1.1 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial V-ATPase_G PF03179.15 EFE41623.1 - 7.7e-21 74.6 8.5 1e-20 74.2 8.5 1.2 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit V-ATPase_G_2 PF16999.5 EFE41623.1 - 0.044 14.2 6.1 0.052 14.0 5.6 1.4 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit DUF4407 PF14362.6 EFE41623.1 - 1.2 8.5 7.5 1.4 8.2 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) O-antigen_lig PF13425.6 EFE41623.1 - 2.1 7.0 3.1 2.5 6.8 3.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein ATP-synt_B PF00430.18 EFE41623.1 - 2.5 8.2 9.6 7.2 6.7 9.6 1.7 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Helicase_C PF00271.31 EFE41625.1 - 3.1e-20 72.6 0.0 8e-20 71.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE41625.1 - 6e-20 71.9 0.0 1.2e-19 70.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFE41625.1 - 3.8e-15 56.1 0.0 1.1e-14 54.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EFE41625.1 - 0.0046 16.2 0.0 0.0083 15.4 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 EFE41625.1 - 0.0065 16.2 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase F_actin_cap_B PF01115.17 EFE41626.1 - 6.1e-101 337.0 0.0 5.9e-99 330.5 0.0 2.0 2 0 0 2 2 2 2 F-actin capping protein, beta subunit Med11 PF10280.9 EFE41627.1 - 6.2e-42 143.3 0.5 8.4e-42 142.9 0.5 1.2 1 0 0 1 1 1 1 Mediator complex protein DUF5344 PF17279.2 EFE41627.1 - 0.052 14.1 0.5 0.12 13.0 0.5 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5344) WD40 PF00400.32 EFE41628.1 - 2.7e-49 164.1 26.8 7e-09 36.2 0.4 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EFE41628.1 - 6.9e-15 55.4 0.0 1e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EFE41628.1 - 7e-14 51.9 0.9 0.021 15.1 0.0 5.3 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE41628.1 - 1.2e-07 30.8 1.0 0.00012 20.9 0.1 3.8 3 1 1 4 4 4 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFE41628.1 - 0.00062 18.8 0.1 0.077 11.9 0.0 3.1 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EFE41628.1 - 0.0025 16.6 0.1 1.3 7.6 0.0 3.1 2 1 1 3 3 3 2 Nup133 N terminal like eIF2A PF08662.11 EFE41628.1 - 0.011 15.6 0.2 0.051 13.4 0.1 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF4550 PF15084.6 EFE41628.1 - 0.056 13.9 0.0 0.25 11.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4550) PALB2_WD40 PF16756.5 EFE41628.1 - 3.6 6.4 5.2 0.7 8.8 0.8 2.0 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Abhydrolase_6 PF12697.7 EFE41629.1 - 1.5e-22 81.3 0.0 2.1e-22 80.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFE41629.1 - 1.5e-09 37.9 0.0 2.7e-09 37.1 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE41629.1 - 4.7e-05 22.8 0.0 8.7e-05 21.9 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 EFE41629.1 - 0.08 12.7 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 EFE41629.1 - 0.098 12.8 0.1 0.8 9.8 0.1 2.2 1 1 0 1 1 1 0 Thioesterase domain Ser_hydrolase PF06821.13 EFE41629.1 - 0.1 12.4 0.1 0.38 10.6 0.0 1.9 2 0 0 2 2 2 0 Serine hydrolase Lipase_3 PF01764.25 EFE41629.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF2417 PF10329.9 EFE41630.1 - 1.7e-80 269.8 0.5 2.4e-80 269.3 0.5 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Pox_A9 PF04835.12 EFE41630.1 - 0.17 12.1 1.7 9.5 6.4 0.1 2.6 2 0 0 2 2 2 0 A9 protein conserved region Trp_oprn_chp PF09534.10 EFE41630.1 - 1.7 8.4 9.2 0.093 12.5 2.6 2.2 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PMSR PF01625.21 EFE41631.1 - 4.3e-61 205.6 0.5 5.1e-61 205.3 0.5 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Pro_dh PF01619.18 EFE41632.1 - 9.7e-62 209.2 0.0 1.5e-61 208.6 0.0 1.3 1 0 0 1 1 1 1 Proline dehydrogenase GFA PF04828.14 EFE41633.1 - 0.042 14.2 1.2 0.099 13.0 1.2 1.6 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme Ribosomal_60s PF00428.19 EFE41633.1 - 0.14 12.8 4.7 0.21 12.2 4.7 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Glyco_hydro_16 PF00722.21 EFE41634.1 - 1.4e-44 151.7 2.5 2.1e-44 151.1 2.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Alk_phosphatase PF00245.20 EFE41635.1 - 1.3e-107 360.3 0.0 1.7e-107 360.0 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EFE41635.1 - 0.00025 20.5 0.0 0.00061 19.2 0.0 1.6 2 0 0 2 2 2 1 Metalloenzyme superfamily DUF498 PF04430.14 EFE41636.1 - 0.002 18.2 0.0 0.0041 17.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) TAF6_C PF07571.13 EFE41636.1 - 0.067 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 TAF6 C-terminal HEAT repeat domain ABC_membrane PF00664.23 EFE41637.1 - 2.5e-35 122.5 8.1 2.5e-35 122.5 8.1 1.9 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFE41637.1 - 2.9e-33 115.3 0.0 5.9e-33 114.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFE41637.1 - 2.8e-07 30.2 0.0 5e-05 22.8 0.0 2.8 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFE41637.1 - 0.023 15.0 0.0 0.09 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EFE41637.1 - 0.027 14.7 0.5 0.58 10.4 0.5 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 EFE41637.1 - 0.048 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 EFE41637.1 - 0.055 13.2 0.2 0.13 12.0 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EFE41637.1 - 0.075 13.4 1.2 0.42 11.0 1.2 2.2 1 1 0 1 1 1 0 AAA ATPase domain eIF3g PF12353.8 EFE41642.1 - 7e-45 152.5 1.6 7e-45 152.5 1.6 1.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EFE41642.1 - 9.7e-17 60.6 0.1 1.7e-16 59.8 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_7 PF18586.1 EFE41642.1 - 0.011 16.1 0.1 0.026 14.8 0.1 1.6 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 TackOD1 PF18551.1 EFE41642.1 - 0.057 13.1 0.1 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 RRM_occluded PF16842.5 EFE41642.1 - 0.088 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif NMO PF03060.15 EFE41643.1 - 1.9e-56 191.9 1.3 2.6e-56 191.4 1.3 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EFE41643.1 - 5.3e-11 42.1 1.1 1.4e-09 37.4 1.1 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EFE41643.1 - 1.2e-07 31.1 2.0 2.3e-07 30.2 2.0 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase DHO_dh PF01180.21 EFE41643.1 - 0.0036 16.6 0.2 0.0058 15.9 0.2 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 EFE41643.1 - 0.0063 15.7 1.9 0.01 15.0 1.3 1.6 2 0 0 2 2 2 1 Conserved region in glutamate synthase Pterin_bind PF00809.22 EFE41644.1 - 3.3e-81 272.6 0.2 4.4e-81 272.2 0.2 1.2 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EFE41644.1 - 1.2e-35 122.4 0.0 2.4e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) TIM21 PF08294.11 EFE41646.1 - 1.4e-06 28.2 0.0 0.017 15.0 0.0 2.1 2 0 0 2 2 2 2 TIM21 MR_MLE_C PF13378.6 EFE41647.1 - 5.3e-57 192.9 0.2 3.6e-56 190.2 0.0 1.9 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EFE41647.1 - 8.8e-07 29.2 0.1 1.7e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 EFE41647.1 - 0.0056 15.9 0.0 0.015 14.5 0.0 1.6 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus Aminotran_5 PF00266.19 EFE41648.1 - 3.8e-26 91.9 0.0 6.5e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V PWI PF01480.17 EFE41649.1 - 4.2e-17 62.2 0.7 1.2e-16 60.8 0.7 1.8 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 EFE41649.1 - 0.033 14.0 0.0 0.09 12.6 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUD1_2 PF18457.1 EFE41650.1 - 5.2e-43 147.1 0.1 6.1e-43 146.8 0.1 1.0 1 0 0 1 1 1 1 Up-Regulated in long-lived daf-2 PGI PF00342.19 EFE41652.1 - 1.9e-240 798.6 2.4 2.1e-240 798.4 2.4 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Urease_beta PF00699.20 EFE41652.1 - 0.02 14.9 0.0 0.045 13.8 0.0 1.5 1 0 0 1 1 1 0 Urease beta subunit FAM176 PF14851.6 EFE41653.1 - 0.39 10.4 1.2 0.74 9.5 1.2 1.4 1 0 0 1 1 1 0 FAM176 family Ribosomal_S21 PF01165.20 EFE41654.1 - 7.4e-08 32.0 0.7 7.4e-08 32.0 0.7 1.8 2 0 0 2 2 2 1 Ribosomal protein S21 Spidroin_MaSp PF11260.8 EFE41654.1 - 0.11 12.8 0.7 1 9.7 0.4 2.3 2 0 0 2 2 2 0 Major ampullate spidroin 1 and 2 Rhodanese PF00581.20 EFE41655.1 - 1.9e-09 38.0 0.0 2.3e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_28 PF02636.17 EFE41656.1 - 1.3e-78 264.2 0.0 3.3e-64 217.0 0.0 2.1 2 0 0 2 2 2 2 Putative S-adenosyl-L-methionine-dependent methyltransferase RRM_1 PF00076.22 EFE41657.1 - 2.7e-05 23.9 0.0 5.1e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gar1 PF04410.14 EFE41659.1 - 3.5e-45 153.5 0.2 6.8e-45 152.6 0.2 1.4 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region YL1 PF05764.13 EFE41659.1 - 8.4 6.4 12.5 16 5.5 0.5 2.2 2 0 0 2 2 2 0 YL1 nuclear protein HET PF06985.11 EFE41660.1 - 2.8e-10 40.7 0.0 5.5e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Glyco_transf_22 PF03901.17 EFE41661.1 - 1e-43 150.1 9.3 1.2e-43 149.9 9.3 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family YitT_membrane PF02588.15 EFE41661.1 - 0.0021 17.4 3.0 0.0033 16.8 2.7 1.4 1 1 0 1 1 1 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 AdenylateSensor PF16579.5 EFE41661.1 - 0.16 12.4 0.1 3.9 8.0 0.0 2.2 2 0 0 2 2 2 0 Adenylate sensor of SNF1-like protein kinase zf-C2H2_4 PF13894.6 EFE41662.1 - 1.1e-06 28.9 11.2 0.029 15.2 1.1 4.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE41662.1 - 1.2e-05 25.5 28.4 0.00015 22.0 1.4 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE41662.1 - 1.6 9.3 11.1 13 6.4 0.0 3.9 3 0 0 3 3 3 0 Zinc-finger double domain DUF1266 PF06889.11 EFE41663.1 - 0.081 13.0 0.1 0.086 12.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) CENP-T_C PF15511.6 EFE41666.1 - 2.2e-08 34.2 0.1 2.7e-08 33.9 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EFE41666.1 - 4.3e-05 23.9 0.1 5.1e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EFE41666.1 - 0.00014 21.9 0.1 0.0002 21.4 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EFE41666.1 - 0.00063 20.1 0.1 0.00086 19.7 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EFE41666.1 - 0.00065 19.9 0.1 0.0012 19.0 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EFE41666.1 - 0.011 15.9 0.0 0.013 15.6 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFE41666.1 - 0.055 13.5 0.0 0.086 12.9 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.24 EFE41667.1 - 2.5e-49 167.0 3.3 2.8e-49 166.8 3.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EFE41667.1 - 5.3e-06 26.7 0.0 8.2e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EFE41667.1 - 6e-05 23.1 0.7 8.5e-05 22.6 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EFE41667.1 - 0.0013 19.4 1.2 0.0015 19.1 1.2 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EFE41667.1 - 0.0077 16.5 0.2 0.025 14.9 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 EFE41667.1 - 0.025 14.6 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID-31kDa PF02291.15 EFE41667.1 - 0.13 12.3 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Exo5 PF09810.9 EFE41668.1 - 3.6e-125 418.3 0.0 5.8e-125 417.6 0.0 1.3 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease Mpv17_PMP22 PF04117.12 EFE41668.1 - 2.4e-13 50.1 0.4 5.7e-13 48.9 0.4 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family PDDEXK_1 PF12705.7 EFE41668.1 - 0.013 15.4 0.0 2.9 7.7 0.0 3.0 3 0 0 3 3 3 0 PD-(D/E)XK nuclease superfamily ChAPs PF09295.10 EFE41670.1 - 1.6e-124 415.9 0.0 5e-94 315.5 0.0 2.2 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.17 EFE41670.1 - 0.00026 20.9 0.1 0.83 9.9 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFE41670.1 - 0.00035 21.1 1.7 0.58 11.1 0.0 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFE41670.1 - 0.00039 20.1 0.2 7 6.7 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFE41670.1 - 0.0027 18.2 0.0 5.5 7.6 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFE41670.1 - 0.0037 17.4 0.2 0.58 10.3 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFE41670.1 - 0.038 14.3 0.6 0.89 9.9 0.1 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat CDC45 PF02724.14 EFE41670.1 - 0.16 10.2 4.4 0.2 9.9 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein ANAPC3 PF12895.7 EFE41670.1 - 0.57 10.4 3.5 1.1 9.5 0.2 2.9 3 1 0 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 PBP1_TM PF14812.6 EFE41670.1 - 0.66 10.4 6.3 0.49 10.8 4.3 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.12 EFE41670.1 - 0.9 7.7 9.2 1.2 7.3 9.2 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EFE41670.1 - 2.2 7.6 8.3 4.3 6.6 8.3 1.4 1 0 0 1 1 1 0 NOA36 protein RRN3 PF05327.11 EFE41670.1 - 4.5 5.7 5.3 6.9 5.1 5.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TPR_14 PF13428.6 EFE41671.1 - 0.041 14.7 2.7 5.3 8.1 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Kinesin PF00225.23 EFE41672.1 - 3.5e-56 190.6 0.0 7.3e-56 189.5 0.0 1.6 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFE41672.1 - 1.8e-13 50.7 0.0 2.4e-12 47.0 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding bZIP_2 PF07716.15 EFE41672.1 - 0.0032 17.5 1.6 0.01 15.9 1.6 1.9 1 0 0 1 1 1 1 Basic region leucine zipper DUF87 PF01935.17 EFE41672.1 - 0.86 9.6 3.8 3.8 7.5 0.0 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain zf-PARP PF00645.18 EFE41673.1 - 3e-22 79.3 0.5 3e-22 79.3 0.5 3.8 2 1 1 3 3 3 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DUF1168 PF06658.12 EFE41674.1 - 7.5e-41 139.1 10.9 1.3e-40 138.4 10.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Lyase_catalyt PF09093.11 EFE41674.1 - 0.005 16.0 0.0 0.0072 15.5 0.0 1.1 1 0 0 1 1 1 1 Lyase, catalytic PPL5 PF18168.1 EFE41674.1 - 0.16 11.2 2.6 0.22 10.8 2.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 ERK-JNK_inhib PF15002.6 EFE41674.1 - 1 9.0 12.5 1.6 8.4 12.5 1.2 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor Vfa1 PF08432.10 EFE41674.1 - 2.8 8.2 12.4 5.3 7.3 12.4 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Peptidase_S49_N PF08496.10 EFE41674.1 - 5.6 7.0 10.8 1.5 8.9 8.0 1.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Cpn60_TCP1 PF00118.24 EFE41675.1 - 6.7e-164 546.1 1.8 7.8e-164 545.9 1.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Lactamase_B_2 PF12706.7 EFE41676.1 - 3.2e-10 39.9 0.0 2.7e-09 36.8 0.0 2.1 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFE41676.1 - 2e-08 34.3 0.0 5.1e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain BCS1_N PF08740.11 EFE41677.1 - 1e-48 165.8 0.6 1.5e-48 165.3 0.6 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EFE41677.1 - 2e-18 67.1 0.0 4e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFE41677.1 - 6.9e-06 26.5 0.1 2.1e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EFE41677.1 - 0.00045 19.5 0.0 0.0009 18.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 EFE41677.1 - 0.0058 16.8 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFE41677.1 - 0.011 15.9 0.0 0.086 13.1 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EFE41677.1 - 0.013 15.0 0.0 0.03 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 EFE41677.1 - 0.016 15.2 0.0 0.046 13.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EFE41677.1 - 0.017 14.9 0.0 0.06 13.1 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_11 PF13086.6 EFE41677.1 - 0.028 14.2 0.0 0.065 13.0 0.0 1.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFE41677.1 - 0.035 14.5 0.0 0.11 12.9 0.0 1.9 2 0 0 2 2 1 0 RNA helicase ABC_tran PF00005.27 EFE41677.1 - 0.038 14.5 0.0 0.076 13.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 EFE41677.1 - 0.044 14.3 0.0 0.11 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFE41677.1 - 0.13 12.2 0.0 0.46 10.4 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 EFE41677.1 - 0.14 11.9 0.0 0.74 9.5 0.0 2.1 1 1 0 2 2 2 0 AAA domain ATPase PF06745.13 EFE41677.1 - 0.14 11.5 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 KaiC Rad17 PF03215.15 EFE41677.1 - 0.2 11.6 0.0 0.58 10.1 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain Sex_peptide PF08138.11 EFE41678.1 - 0.09 12.9 1.9 0.4 10.9 1.9 2.1 1 0 0 1 1 1 0 Sex peptide (SP) family PIG-S PF10510.9 EFE41678.1 - 0.29 9.9 0.0 0.29 9.9 0.0 2.8 3 0 0 3 3 3 0 Phosphatidylinositol-glycan biosynthesis class S protein RabGAP-TBC PF00566.18 EFE41679.1 - 6.5e-34 117.5 1.4 1.7e-32 112.8 0.2 3.2 2 1 0 2 2 2 1 Rab-GTPase-TBC domain Glyco_transf_41 PF13844.6 EFE41680.1 - 3.2e-102 342.4 0.1 7.3e-52 176.4 0.0 3.3 2 1 1 3 3 3 3 Glycosyl transferase family 41 TPR_2 PF07719.17 EFE41680.1 - 5.9e-15 54.1 10.8 0.0011 18.9 0.2 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFE41680.1 - 6.6e-15 54.5 12.6 0.0015 18.1 0.5 6.2 3 2 3 6 6 6 4 TPR repeat TPR_1 PF00515.28 EFE41680.1 - 5.7e-14 51.2 9.4 0.00099 18.8 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFE41680.1 - 1.7e-08 34.0 8.9 0.039 14.2 0.1 5.8 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFE41680.1 - 8.6e-07 29.3 5.3 0.044 14.6 0.0 5.5 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFE41680.1 - 1.7e-06 28.6 9.0 0.23 12.1 0.3 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFE41680.1 - 2e-06 27.8 5.5 3.6 8.2 0.0 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE41680.1 - 4.4e-06 26.9 8.7 0.21 11.9 0.2 5.3 3 2 1 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFE41680.1 - 4.5e-06 26.4 14.4 0.48 10.4 0.7 6.1 5 0 0 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE41680.1 - 6.2e-05 23.1 0.6 0.00063 19.9 0.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFE41680.1 - 8.6e-05 23.0 8.4 0.089 13.3 0.2 3.8 3 2 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 EFE41680.1 - 0.00061 20.2 0.8 0.26 11.7 0.0 2.8 2 0 0 2 2 2 1 Bacterial transcriptional activator domain TPR_7 PF13176.6 EFE41680.1 - 0.0064 16.4 7.4 0.75 10.0 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFE41680.1 - 0.025 13.8 2.0 2.8 7.1 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFE41680.1 - 0.95 9.7 5.6 1.3 9.2 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MCM_bind PF09739.9 EFE41681.1 - 0.73 8.2 8.7 0.01 14.3 1.6 1.4 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor DUF3915 PF13054.6 EFE41681.1 - 2.2 8.3 13.1 1 9.3 3.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DUF4770 PF15994.5 EFE41681.1 - 5.8 7.1 7.1 0.51 10.6 1.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) V_ATPase_I PF01496.19 EFE41681.1 - 8.8 4.1 4.9 15 3.3 4.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ribosomal_L11_N PF03946.14 EFE41682.1 - 5.5e-19 67.8 1.1 5.1e-17 61.5 1.1 2.2 1 1 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EFE41682.1 - 2.6e-14 53.5 0.0 4.8e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Sec23_trunk PF04811.15 EFE41683.1 - 5.6e-78 261.9 0.0 7.8e-78 261.4 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EFE41683.1 - 7.5e-29 100.3 0.0 1.5e-28 99.3 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EFE41683.1 - 5.7e-25 87.1 0.2 1.3e-24 86.0 0.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EFE41683.1 - 1.3e-14 54.0 4.5 2.3e-14 53.1 4.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EFE41683.1 - 0.0011 18.9 0.0 0.0032 17.3 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EFE41683.1 - 0.093 12.1 0.8 0.2 11.1 0.3 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DNA_primase_lrg PF04104.14 EFE41684.1 - 5.9e-85 284.9 0.0 8.6e-85 284.3 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Phage_head_chap PF11113.8 EFE41684.1 - 0.12 12.5 0.1 0.55 10.4 0.1 2.1 1 0 0 1 1 1 0 Head assembly gene product ADK PF00406.22 EFE41685.1 - 1e-35 123.1 0.0 7.5e-19 68.3 0.0 2.1 1 1 1 2 2 2 2 Adenylate kinase ADK_lid PF05191.14 EFE41685.1 - 2.5e-16 59.4 0.0 4e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 EFE41685.1 - 1.9e-13 51.0 0.0 3.8e-12 46.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFE41685.1 - 5.9e-05 23.6 0.0 0.00022 21.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFE41685.1 - 0.013 15.7 0.0 0.028 14.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 EFE41685.1 - 0.089 11.8 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EFE41685.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EFE41685.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFE41685.1 - 0.19 11.8 0.1 0.36 10.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SNase PF00565.17 EFE41686.1 - 8.3e-12 45.5 0.0 1.2e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Mito_carr PF00153.27 EFE41687.1 - 3.5e-56 187.1 3.8 5.4e-22 77.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_C2 PF00648.21 EFE41688.1 - 6.8e-30 104.1 0.0 1e-29 103.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EFE41688.1 - 2.5e-08 34.3 0.0 1e-05 25.9 0.0 3.2 2 1 0 2 2 2 1 Calpain large subunit, domain III MIT PF04212.18 EFE41688.1 - 0.16 12.1 0.5 0.28 11.3 0.5 1.4 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Vta1 PF04652.16 EFE41689.1 - 1.5e-55 187.1 6.8 1.5e-55 187.1 6.8 1.5 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 EFE41689.1 - 1.9e-18 65.9 0.2 5.8e-18 64.3 0.2 1.9 1 0 0 1 1 1 1 Vta1 C-terminal domain Exo_endo_phos PF03372.23 EFE41690.1 - 0.002 17.7 0.0 0.0022 17.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Epimerase PF01370.21 EFE41692.1 - 4.1e-19 69.0 0.0 5.6e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFE41692.1 - 6.4e-09 35.2 0.0 1.5e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EFE41692.1 - 2.7e-07 30.0 0.0 3.8e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFE41692.1 - 7.4e-06 26.0 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFE41692.1 - 0.00045 19.7 0.0 0.00065 19.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EFE41692.1 - 0.015 15.5 0.0 0.045 14.0 0.0 1.9 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Ldh_1_N PF00056.23 EFE41692.1 - 0.14 12.2 0.0 0.4 10.8 0.0 1.7 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain KR PF08659.10 EFE41692.1 - 0.19 11.6 0.0 0.48 10.3 0.0 1.7 1 0 0 1 1 1 0 KR domain Topoisom_I PF01028.20 EFE41693.1 - 1.8e-98 328.4 2.9 1.8e-98 328.4 2.9 2.7 3 1 1 4 4 4 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EFE41693.1 - 2.7e-96 321.2 1.4 2.7e-96 321.2 1.4 3.9 5 0 0 5 5 5 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EFE41693.1 - 9.1e-33 112.0 1.0 3.7e-32 110.1 1.0 2.2 1 0 0 1 1 1 1 C-terminal topoisomerase domain DUF4604 PF15377.6 EFE41693.1 - 0.0098 16.3 26.5 0.0098 16.3 26.5 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF4604) ATP-synt PF00231.19 EFE41694.1 - 1.6e-67 228.2 2.2 2e-67 227.9 2.2 1.1 1 0 0 1 1 1 1 ATP synthase Peptidase_C15 PF01470.17 EFE41695.1 - 0.04 14.1 0.0 0.044 14.0 0.0 1.0 1 0 0 1 1 1 0 Pyroglutamyl peptidase Thioredoxin PF00085.20 EFE41696.1 - 2.6e-23 81.9 0.0 1.4e-18 66.8 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EFE41696.1 - 3.7e-06 27.4 0.1 0.0057 17.1 0.1 2.7 1 1 1 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EFE41696.1 - 0.0036 16.7 0.0 0.043 13.2 0.0 2.0 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EFE41696.1 - 0.046 14.0 0.1 17 5.8 0.1 3.6 3 1 1 4 4 4 0 Thioredoxin-like CCDC53 PF10152.9 EFE41696.1 - 0.21 12.0 9.0 2.6 8.4 2.5 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex TraF PF13728.6 EFE41696.1 - 0.25 11.1 0.0 0.25 11.1 0.0 4.4 4 1 0 4 4 4 0 F plasmid transfer operon protein SOG2 PF10428.9 EFE41696.1 - 0.73 9.0 7.9 1.3 8.2 7.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein SpoIIIAH PF12685.7 EFE41696.1 - 6.2 6.6 10.3 0.81 9.5 4.2 2.0 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF913 PF06025.12 EFE41696.1 - 7.3 5.5 9.3 1.6 7.6 4.6 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) GNAT_acetyltr_2 PF13718.6 EFE41697.1 - 2.7e-98 327.9 0.0 4.8e-98 327.1 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EFE41697.1 - 2.5e-91 305.6 0.0 4.6e-91 304.7 0.0 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EFE41697.1 - 5.1e-65 218.6 0.0 1.3e-64 217.3 0.0 1.7 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 EFE41697.1 - 8.7e-35 118.5 0.0 2.8e-34 116.9 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 EFE41697.1 - 0.00072 19.3 0.0 0.051 13.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain Acetyltransf_1 PF00583.25 EFE41697.1 - 0.016 15.4 0.0 0.064 13.5 0.0 2.0 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family AAA_22 PF13401.6 EFE41697.1 - 0.027 14.7 0.0 0.46 10.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF202 PF02656.15 EFE41699.1 - 0.46 11.0 3.0 3.3 8.2 1.5 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF202) FtsX PF02687.21 EFE41699.1 - 2.1 8.9 6.5 26 5.3 6.5 2.2 1 1 0 1 1 1 0 FtsX-like permease family Glyco_transf_90 PF05686.12 EFE41700.1 - 2.1e-15 56.5 0.0 1.3e-07 30.9 0.0 3.7 2 2 1 3 3 3 2 Glycosyl transferase family 90 Glyco_hydro_16 PF00722.21 EFE41701.1 - 3.6e-08 33.1 0.2 8e-08 32.0 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 DSPc PF00782.20 EFE41702.1 - 8.2e-16 58.0 0.0 3.3e-09 36.7 0.0 2.1 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Vfa1 PF08432.10 EFE41703.1 - 8.5e-36 124.0 33.5 7.8e-23 81.7 30.7 2.0 1 1 1 2 2 2 2 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 EFE41703.1 - 2e-05 24.6 14.4 2.6e-05 24.2 14.4 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Rtf2 PF04641.12 EFE41703.1 - 0.00019 20.9 16.7 0.00023 20.6 16.7 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger Atrophin-1 PF03154.15 EFE41703.1 - 0.0087 14.4 13.6 0.011 14.1 13.6 1.2 1 0 0 1 1 1 1 Atrophin-1 family CDC45 PF02724.14 EFE41703.1 - 0.038 12.3 18.9 0.043 12.1 18.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 EFE41703.1 - 0.052 11.6 8.1 0.058 11.5 8.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ycf1 PF05758.12 EFE41703.1 - 0.065 11.1 17.0 0.076 10.9 17.0 1.0 1 0 0 1 1 1 0 Ycf1 SpoIIIAH PF12685.7 EFE41703.1 - 0.087 12.6 14.1 0.12 12.1 14.1 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Rrn6 PF10214.9 EFE41703.1 - 0.21 10.0 10.4 0.24 9.9 10.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF262 PF03235.14 EFE41703.1 - 0.23 11.6 8.1 0.27 11.4 8.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 FAM60A PF15396.6 EFE41703.1 - 0.27 11.2 12.6 0.36 10.8 12.6 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF913 PF06025.12 EFE41703.1 - 0.31 10.0 7.7 0.38 9.7 7.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 EFE41703.1 - 0.32 9.7 13.0 0.35 9.6 13.0 1.1 1 0 0 1 1 1 0 Presenilin MSA_2 PF00985.17 EFE41703.1 - 0.59 10.5 6.4 0.75 10.1 6.4 1.2 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family SpoIIP PF07454.11 EFE41703.1 - 0.6 9.5 14.0 0.74 9.2 14.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 EFE41703.1 - 0.79 8.4 14.5 1 8.0 14.5 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MCM_bind PF09739.9 EFE41703.1 - 0.82 8.0 12.6 0.95 7.8 12.6 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DDHD PF02862.17 EFE41703.1 - 0.97 9.5 7.8 1.2 9.2 7.8 1.2 1 0 0 1 1 1 0 DDHD domain AAA_11 PF13086.6 EFE41703.1 - 1 9.1 11.8 1.2 8.9 11.8 1.3 1 0 0 1 1 1 0 AAA domain GNAT_acetyltr_2 PF13718.6 EFE41703.1 - 1 8.7 8.3 1.4 8.3 8.3 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF2722 PF10846.8 EFE41703.1 - 1 8.2 17.1 1.4 7.8 17.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Borrelia_P83 PF05262.11 EFE41703.1 - 1.2 7.5 22.3 1.4 7.3 22.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CLN3 PF02487.17 EFE41703.1 - 1.4 7.9 4.1 1.5 7.8 4.1 1.2 1 0 0 1 1 1 0 CLN3 protein ATP11 PF06644.11 EFE41703.1 - 1.7 8.4 17.3 2.2 8.0 17.3 1.3 1 0 0 1 1 1 0 ATP11 protein DUF2828 PF11443.8 EFE41703.1 - 1.8 6.6 14.7 2 6.4 14.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF908 PF06012.12 EFE41703.1 - 1.9 7.8 7.3 2.1 7.7 7.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Paramyxo_ncap PF00973.19 EFE41703.1 - 1.9 7.3 9.8 2.1 7.2 9.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SAPS PF04499.15 EFE41703.1 - 2.1 7.1 13.8 2.3 6.9 13.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PTPRCAP PF15713.5 EFE41703.1 - 2.2 8.6 17.8 3.2 8.0 17.8 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Paf1 PF03985.13 EFE41703.1 - 2.4 7.1 27.3 3.9 6.4 27.3 1.3 1 0 0 1 1 1 0 Paf1 DUF4407 PF14362.6 EFE41703.1 - 2.5 7.4 11.1 2.9 7.2 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TP53IP5 PF15331.6 EFE41703.1 - 2.5 8.2 13.1 3 7.9 13.1 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Zip PF02535.22 EFE41703.1 - 3 7.0 8.3 3.1 6.9 8.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 EFE41703.1 - 3.1 6.5 19.0 3.6 6.3 19.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_polI_A34 PF08208.11 EFE41703.1 - 3.5 7.7 31.0 5.5 7.0 31.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 V_ATPase_I PF01496.19 EFE41703.1 - 4.5 5.1 12.7 5.6 4.8 12.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4746 PF15928.5 EFE41703.1 - 4.5 6.6 19.0 6.1 6.2 19.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SLC12 PF03522.15 EFE41703.1 - 5.6 5.9 15.4 6.4 5.7 15.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 FancD2 PF14631.6 EFE41703.1 - 5.8 4.2 12.3 6.2 4.1 12.3 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Med5 PF08689.10 EFE41703.1 - 6.5 4.4 10.9 7.6 4.2 10.9 1.0 1 0 0 1 1 1 0 Mediator complex subunit Med5 PPL5 PF18168.1 EFE41703.1 - 6.8 5.9 15.0 8.2 5.6 15.0 1.2 1 0 0 1 1 1 0 Prim-pol family 5 SID-1_RNA_chan PF13965.6 EFE41703.1 - 7.4 4.9 5.5 7.7 4.8 5.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DNA_pol_phi PF04931.13 EFE41703.1 - 9.3 4.2 20.9 10 4.1 20.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 EFE41703.1 - 9.3 4.6 18.6 11 4.4 18.6 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CarboxypepD_reg PF13620.6 EFE41704.1 - 0.0048 17.1 0.7 0.11 12.8 0.1 2.4 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain Asp PF00026.23 EFE41705.1 - 1.4e-70 238.2 1.4 1.7e-70 237.9 1.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFE41705.1 - 9e-10 39.1 0.5 3.1e-07 30.8 0.5 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFE41705.1 - 0.00033 21.3 0.1 0.047 14.3 0.0 2.7 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 EFE41705.1 - 0.0069 16.9 0.1 1.9 9.1 0.0 2.6 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease RNA_pol_Rpb1_1 PF04997.12 EFE41706.1 - 9.8e-82 274.8 0.0 1.8e-81 273.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EFE41706.1 - 3.5e-79 266.0 0.8 3.5e-79 266.0 0.8 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFE41706.1 - 3.6e-71 238.7 0.0 6.8e-71 237.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EFE41706.1 - 6.3e-34 117.2 0.0 1.3e-33 116.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EFE41706.1 - 3.7e-25 88.0 0.6 1.1e-24 86.4 0.6 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 SAP PF02037.27 EFE41707.1 - 0.0001 21.9 0.1 0.0013 18.4 0.0 2.2 2 0 0 2 2 2 1 SAP domain HHV-1_VABD PF16852.5 EFE41707.1 - 0.068 13.2 0.8 0.24 11.4 0.2 2.2 2 0 0 2 2 2 0 Herpes viral adaptor-to-host cellular mRNA binding domain FMN_dh PF01070.18 EFE41708.1 - 4.8e-105 351.4 0.0 2e-102 342.8 0.0 2.1 2 0 0 2 2 2 2 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EFE41708.1 - 7.9e-18 64.4 0.0 1.5e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EFE41708.1 - 0.00098 18.4 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 EFE41708.1 - 0.016 14.5 0.0 0.067 12.5 0.0 1.8 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG CbiJ PF02571.14 EFE41708.1 - 0.057 12.9 0.0 4.6 6.6 0.0 2.3 2 0 0 2 2 2 0 Precorrin-6x reductase CbiJ/CobK NMO PF03060.15 EFE41708.1 - 0.062 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase IMPDH PF00478.25 EFE41708.1 - 0.14 11.1 0.3 0.34 9.8 0.1 1.7 1 1 1 2 2 2 0 IMP dehydrogenase / GMP reductase domain TatD_DNase PF01026.21 EFE41709.1 - 3.6e-41 141.2 0.0 4.1e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Y_phosphatase2 PF03162.13 EFE41711.1 - 2e-42 144.6 0.0 2.9e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EFE41711.1 - 8e-09 35.8 0.0 1e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EFE41711.1 - 1.1e-05 25.2 0.0 1.5e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFE41711.1 - 0.0013 18.4 0.0 0.0018 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFE41711.1 - 0.13 12.4 0.1 0.21 11.7 0.1 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF1133 PF06576.11 EFE41711.1 - 0.16 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) Trypsin_2 PF13365.6 EFE41713.1 - 1.9e-06 28.8 0.0 3.1e-05 24.9 0.0 2.8 3 1 0 3 3 3 1 Trypsin-like peptidase domain Peptidase_S64 PF08192.11 EFE41713.1 - 0.00077 18.1 0.0 0.0011 17.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S64 Peptidase_S32 PF05579.13 EFE41713.1 - 0.0019 17.5 0.0 0.015 14.5 0.0 2.0 2 0 0 2 2 2 1 Equine arteritis virus serine endopeptidase S32 Aa_trans PF01490.18 EFE41714.1 - 1.9e-71 240.9 29.0 2.3e-71 240.7 29.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF3043 PF11241.8 EFE41714.1 - 3.3 7.7 8.5 30 4.6 0.2 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3043) Rad52_Rad22 PF04098.15 EFE41716.1 - 2.4e-39 134.7 1.0 2.3e-20 73.1 0.8 2.3 1 1 1 2 2 2 2 Rad52/22 family double-strand break repair protein COX5B PF01215.19 EFE41716.1 - 0.032 13.9 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Vb GATA PF00320.27 EFE41717.1 - 0.064 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 GATA zinc finger zf-C2H2_6 PF13912.6 EFE41717.1 - 0.088 12.8 0.3 0.18 11.8 0.3 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger UBA PF00627.31 EFE41717.1 - 0.13 12.2 0.0 0.69 9.9 0.0 2.2 3 0 0 3 3 3 0 UBA/TS-N domain zf-C2H2 PF00096.26 EFE41717.1 - 0.17 12.4 0.2 0.33 11.5 0.2 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type ArfGap PF01412.18 EFE41717.1 - 0.62 10.2 9.1 6.3 6.9 8.8 2.7 2 1 0 2 2 2 0 Putative GTPase activating protein for Arf AAA_13 PF13166.6 EFE41717.1 - 2.1 6.9 22.3 3.4 6.2 22.3 1.3 1 0 0 1 1 1 0 AAA domain FapA PF03961.13 EFE41717.1 - 2.2 6.8 19.0 3.4 6.2 19.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Trypan_PARP PF05887.11 EFE41718.1 - 0.0033 17.4 1.9 0.0051 16.8 1.9 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Cut8 PF08559.10 EFE41719.1 - 8.3e-71 238.4 0.0 9.7e-71 238.2 0.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein rRNA_proc-arch PF13234.6 EFE41720.1 - 1.5e-92 310.4 1.0 3.1e-92 309.3 1.0 1.6 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 EFE41720.1 - 2.6e-28 98.8 1.8 3.6e-28 98.3 0.3 2.1 3 0 0 3 3 3 1 DSHCT (NUC185) domain DEAD PF00270.29 EFE41720.1 - 8.5e-19 68.0 0.1 2.9e-18 66.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE41720.1 - 3.5e-06 27.3 0.1 2.3e-05 24.7 0.1 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE41720.1 - 2.2e-05 24.5 0.0 5.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EFE41720.1 - 0.038 13.1 0.0 0.091 11.8 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 EFE41720.1 - 0.072 13.0 0.2 0.29 11.0 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF5388 PF17363.2 EFE41720.1 - 0.086 13.1 0.6 1.2 9.3 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5388) AAA_22 PF13401.6 EFE41720.1 - 0.13 12.5 0.1 0.69 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain IKI3 PF04762.12 EFE41721.1 - 1.4e-290 966.5 0.0 3.9e-289 961.8 0.0 2.0 1 1 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 EFE41721.1 - 0.00052 20.2 0.2 2.2 8.7 0.0 4.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain MDD_C PF18376.1 EFE41722.1 - 1.9e-61 207.1 0.0 2.6e-61 206.6 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EFE41722.1 - 2.9e-10 40.3 1.7 6.7e-10 39.1 1.7 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain Syntaxin_2 PF14523.6 EFE41723.1 - 2.9e-23 82.2 7.5 3.3e-23 81.9 2.2 2.4 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EFE41723.1 - 9.8e-15 54.3 1.9 9.8e-15 54.3 1.9 2.1 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 EFE41723.1 - 1.4e-06 28.2 7.9 2.4e-06 27.4 7.9 1.5 1 1 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.21 EFE41723.1 - 0.00024 20.8 0.8 0.0011 18.8 0.3 2.3 2 1 0 2 2 2 1 Synaptobrevin T3SSipB PF16535.5 EFE41723.1 - 0.01 16.3 4.5 0.061 13.8 3.1 2.4 2 0 0 2 2 2 0 Type III cell invasion protein SipB DUF334 PF03904.13 EFE41723.1 - 0.014 15.0 3.5 0.27 10.7 1.5 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF334) SepF PF04472.12 EFE41723.1 - 0.056 13.7 0.0 0.27 11.5 0.0 2.0 2 0 0 2 2 2 0 Cell division protein SepF DUF883 PF05957.13 EFE41723.1 - 0.092 13.4 9.7 0.57 10.8 0.2 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Fib_alpha PF08702.10 EFE41723.1 - 0.25 11.5 2.2 1 9.5 0.1 2.5 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF5345 PF17280.2 EFE41723.1 - 0.59 10.2 0.1 0.59 10.2 0.1 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5345) DUF16 PF01519.16 EFE41723.1 - 0.93 10.0 6.1 0.97 10.0 0.8 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 Ndc1_Nup PF09531.10 EFE41724.1 - 1.3e-166 555.9 1.2 1.5e-166 555.7 1.2 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup DUF3984 PF13136.6 EFE41725.1 - 7.1e-95 318.2 16.3 1.1e-94 317.6 16.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) OTCace PF00185.24 EFE41726.1 - 5.9e-45 153.1 0.0 9.4e-45 152.5 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 EFE41726.1 - 8.1e-44 149.2 0.0 1.2e-43 148.6 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain DUF3712 PF12505.8 EFE41727.1 - 9.5e-08 32.4 0.5 0.008 16.4 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF3712) Cu-oxidase_2 PF07731.14 EFE41729.1 - 9.4e-36 122.6 0.7 1.6e-35 121.8 0.7 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 EFE41729.1 - 3.1e-09 37.2 0.3 3.3e-08 33.8 0.2 2.4 2 1 0 2 2 2 1 Multicopper oxidase ALS_ss_C PF10369.9 EFE41730.1 - 9.4e-15 54.6 0.0 2.6e-13 50.0 0.0 2.5 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 EFE41730.1 - 2.2e-12 46.5 0.2 4e-12 45.7 0.2 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EFE41730.1 - 5.3e-08 32.6 0.0 1e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 EFE41730.1 - 0.033 14.2 0.1 12 6.0 0.0 2.6 2 0 0 2 2 2 0 ACT domain KH_1 PF00013.29 EFE41731.1 - 9.4e-07 28.6 0.1 2.2e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 KH domain Helicase_C PF00271.31 EFE41732.1 - 4.8e-13 49.4 0.0 1.4e-10 41.5 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EFE41732.1 - 0.00015 22.4 3.3 0.00015 22.4 3.3 2.4 2 0 0 2 2 2 1 RecQ zinc-binding Evr1_Alr PF04777.13 EFE41732.1 - 2.7 8.5 4.5 1.8 9.1 0.4 2.5 2 1 0 3 3 3 0 Erv1 / Alr family PPR_2 PF13041.6 EFE41733.1 - 3.4e-10 40.0 0.2 0.0084 16.3 0.0 4.7 3 1 1 4 4 4 3 PPR repeat family PPR PF01535.20 EFE41733.1 - 2.7e-07 30.4 1.1 0.21 11.9 0.1 4.3 4 0 0 4 4 4 2 PPR repeat PPR_long PF17177.4 EFE41733.1 - 0.0011 18.4 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ESSS PF10183.9 EFE41733.1 - 0.017 15.3 0.1 0.039 14.2 0.1 1.5 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) PPR_3 PF13812.6 EFE41733.1 - 0.054 13.6 0.1 4.1 7.6 0.0 3.1 2 0 0 2 2 2 0 Pentatricopeptide repeat domain MRP-S25 PF13741.6 EFE41734.1 - 6.3e-80 268.0 5.4 7.8e-80 267.7 5.4 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EFE41734.1 - 0.067 13.4 3.8 3.6 7.9 0.0 2.9 1 1 2 3 3 3 0 Mitochondrial ribosomal protein S23 SOG2 PF10428.9 EFE41735.1 - 2.4e-105 353.7 1.4 2.4e-105 353.7 1.4 4.3 4 1 0 4 4 4 1 RAM signalling pathway protein LRR_4 PF12799.7 EFE41735.1 - 1.1e-12 48.0 5.9 5.7e-05 23.4 0.5 3.9 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFE41735.1 - 9e-12 44.6 4.4 2.7e-07 30.2 0.5 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EFE41735.1 - 0.066 13.8 7.8 40 5.3 0.1 5.7 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 EFE41735.1 - 0.085 12.9 5.7 3.4 8.0 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich repeat Peptidase_S10 PF00450.22 EFE41736.1 - 3.8e-75 253.9 0.0 6e-75 253.2 0.0 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase Tcp11 PF05794.13 EFE41737.1 - 3e-96 323.2 0.0 4.5e-96 322.6 0.0 1.2 1 0 0 1 1 1 1 T-complex protein 11 LIN37 PF15306.6 EFE41737.1 - 0.084 13.1 1.0 0.18 12.0 1.0 1.6 1 0 0 1 1 1 0 LIN37 Ydc2-catalyt PF09159.10 EFE41738.1 - 7.1e-92 308.1 0.0 8.9e-92 307.8 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.13 EFE41738.1 - 1.6e-05 25.1 0.0 0.56 10.3 0.0 3.3 3 0 0 3 3 3 2 Poxvirus A22 protein SAP PF02037.27 EFE41738.1 - 0.00039 20.1 0.6 0.00082 19.1 0.6 1.6 1 0 0 1 1 1 1 SAP domain CTP_transf_like PF01467.26 EFE41740.1 - 0.0004 20.6 0.0 0.0011 19.1 0.0 1.9 1 1 0 1 1 1 1 Cytidylyltransferase-like Aim19 PF10315.9 EFE41741.1 - 0.0057 16.9 2.6 0.0077 16.5 0.4 1.8 1 1 1 2 2 2 1 Altered inheritance of mitochondria protein 19 DUF2243 PF10002.9 EFE41741.1 - 0.094 12.8 0.3 0.11 12.7 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2243) DUF1977 PF09320.11 EFE41742.1 - 1.6e-31 108.6 0.1 3e-31 107.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EFE41742.1 - 1.6e-22 79.3 0.4 2.9e-22 78.6 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain APH PF01636.23 EFE41743.1 - 6.9e-15 55.6 0.0 9.2e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE41743.1 - 0.0096 15.5 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 EFE41743.1 - 0.025 13.8 0.0 3.7 6.7 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase EcKinase PF02958.20 EFE41743.1 - 0.036 13.4 0.0 0.057 12.7 0.0 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase Kdo PF06293.14 EFE41743.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2452 PF10504.9 EFE41744.1 - 0.19 11.2 0.2 0.3 10.5 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2452) Peptidase_C97 PF05903.14 EFE41745.1 - 0.001 18.9 0.1 0.0014 18.5 0.1 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF778 PF05608.12 EFE41745.1 - 0.025 15.0 0.0 0.029 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) HTH_10 PF04967.12 EFE41745.1 - 0.071 12.9 0.2 4.7 7.1 0.0 2.3 2 0 0 2 2 2 0 HTH DNA binding domain LRAT PF04970.13 EFE41745.1 - 0.19 12.0 0.2 0.19 12.0 0.2 1.8 2 1 0 2 2 2 0 Lecithin retinol acyltransferase Ufd2P_core PF10408.9 EFE41746.1 - 3.8e-207 689.8 14.6 4.7e-207 689.5 14.6 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EFE41746.1 - 3.7e-28 97.5 1.4 3.4e-27 94.4 0.5 2.7 2 0 0 2 2 2 1 U-box domain PAP1 PF08601.10 EFE41746.1 - 6.2 6.4 9.7 11 5.6 9.7 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 Steroid_dh PF02544.16 EFE41747.1 - 2.6e-09 37.2 1.4 0.003 17.5 0.1 3.6 3 1 0 3 3 3 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EFE41747.1 - 0.0072 15.9 0.3 0.042 13.4 0.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) Meth_synt_2 PF01717.18 EFE41748.1 - 7.4e-151 502.0 0.0 1.7e-147 490.9 0.0 2.4 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EFE41748.1 - 9.5e-112 373.5 0.0 7.2e-106 354.2 0.0 2.7 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 EFE41748.1 - 5.4e-05 22.5 0.0 0.024 13.8 0.0 2.6 2 0 0 2 2 2 2 Uroporphyrinogen decarboxylase (URO-D) VbhA PF18495.1 EFE41748.1 - 0.067 13.1 0.1 16 5.5 0.0 2.8 2 0 0 2 2 2 0 Antitoxin VbhA SHOCT PF09851.9 EFE41748.1 - 0.48 10.2 2.5 0.48 10.2 0.2 2.3 2 0 0 2 2 2 0 Short C-terminal domain DUF2457 PF10446.9 EFE41749.1 - 6.4 5.8 13.6 8 5.5 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 EFE41749.1 - 6.9 4.6 10.2 8 4.4 10.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi SANT_DAMP1_like PF16282.5 EFE41751.1 - 1.4e-30 105.3 1.2 2.8e-30 104.3 1.2 1.5 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 EFE41751.1 - 0.0002 21.3 3.0 0.0002 21.3 3.0 3.0 2 1 1 3 3 3 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-binding PF00249.31 EFE41751.1 - 0.11 12.7 0.0 0.55 10.5 0.0 2.3 2 1 0 2 2 2 0 Myb-like DNA-binding domain UPF0242 PF06785.11 EFE41751.1 - 1.2 9.2 9.5 0.53 10.4 1.7 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus 60KD_IMP PF02096.20 EFE41752.1 - 0.085 12.8 0.0 0.094 12.6 0.0 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein Connexin PF00029.19 EFE41752.1 - 0.087 12.6 0.1 0.099 12.4 0.1 1.2 1 0 0 1 1 1 0 Connexin ApbA_C PF08546.11 EFE41753.1 - 3.6e-24 85.4 0.0 5.5e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EFE41753.1 - 1.1e-20 73.8 0.0 2.1e-13 50.2 0.0 2.3 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA Ank_2 PF12796.7 EFE41755.1 - 5.5e-42 142.2 7.0 1.1e-11 45.2 0.0 6.4 3 3 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE41755.1 - 2.7e-26 91.6 8.7 1.7e-06 28.4 0.0 8.9 6 3 5 11 11 11 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE41755.1 - 3.1e-24 84.7 9.0 0.0001 22.5 0.1 7.6 4 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE41755.1 - 2e-20 70.7 6.1 0.0012 19.2 0.0 10.7 11 0 0 11 11 11 4 Ankyrin repeat Ank PF00023.30 EFE41755.1 - 2.9e-11 43.3 12.9 0.00032 21.0 0.0 8.8 11 0 0 11 11 11 2 Ankyrin repeat Sacchrp_dh_NADP PF03435.18 EFE41755.1 - 0.00071 19.8 0.2 0.28 11.4 0.2 2.8 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain DEAD PF00270.29 EFE41757.1 - 3.9e-36 124.5 0.0 6.4e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE41757.1 - 2.3e-26 92.3 0.0 7.1e-24 84.3 0.1 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EFE41757.1 - 3.3e-09 37.0 0.0 6.4e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFE41757.1 - 0.00095 18.6 0.0 0.0043 16.4 0.0 1.9 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Rpr2 PF04032.16 EFE41758.1 - 3.9e-24 84.8 0.9 5.9e-24 84.2 0.9 1.3 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-ribbon_3 PF13248.6 EFE41758.1 - 0.59 9.6 2.9 2 7.9 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-Sec23_Sec24 PF04810.15 EFE41758.1 - 0.79 9.8 3.5 1.4 9.0 1.2 2.5 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger NAC PF01849.18 EFE41759.1 - 1.2e-24 86.0 0.5 1.2e-24 86.0 0.5 1.6 2 0 0 2 2 2 1 NAC domain Sigma70_ner PF04546.13 EFE41759.1 - 0.68 9.8 6.4 0.64 9.9 1.7 2.0 2 0 0 2 2 2 0 Sigma-70, non-essential region adh_short PF00106.25 EFE41760.1 - 1.4e-21 76.9 0.0 3.1e-17 62.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFE41760.1 - 1.6e-10 41.0 0.0 2.6e-07 30.5 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE41760.1 - 4.3e-09 36.5 0.0 7.9e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFE41760.1 - 0.0036 16.5 0.0 0.0053 15.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EFE41760.1 - 0.069 13.4 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain zf-C2H2 PF00096.26 EFE41761.1 - 7.9e-09 35.5 11.2 0.00051 20.4 1.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE41761.1 - 5.1e-05 23.5 10.0 6.1e-05 23.3 1.0 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE41761.1 - 0.00066 20.3 9.8 0.12 13.3 1.9 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EFE41761.1 - 0.027 14.9 3.1 0.076 13.4 1.2 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EFE41761.1 - 0.11 12.5 0.7 0.11 12.5 0.7 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EFE41761.1 - 0.66 10.1 3.1 11 6.3 0.3 2.4 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_jaz PF12171.8 EFE41761.1 - 0.68 10.3 3.6 0.87 10.0 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 EFE41761.1 - 1.8 8.6 6.7 0.93 9.6 0.6 2.4 2 0 0 2 2 2 0 BED zinc finger RNA_polI_A34 PF08208.11 EFE41763.1 - 1.1 9.3 14.1 2.1 8.4 14.1 1.5 1 1 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Septin PF00735.18 EFE41764.1 - 5.6e-121 403.1 0.2 5.6e-121 403.1 0.2 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EFE41764.1 - 5.3e-08 32.9 0.4 1.9e-07 31.1 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFE41764.1 - 0.00017 21.2 2.9 0.011 15.3 0.0 3.1 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EFE41764.1 - 0.00023 21.7 4.1 0.028 14.9 0.0 2.9 2 1 0 3 3 3 1 ABC transporter AAA_16 PF13191.6 EFE41764.1 - 0.0017 18.8 0.2 0.0064 16.9 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFE41764.1 - 0.0022 17.9 0.6 0.0022 17.9 0.6 3.5 3 1 0 3 3 3 1 RsgA GTPase Roc PF08477.13 EFE41764.1 - 0.0024 18.1 0.0 0.0058 16.8 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EFE41764.1 - 0.0039 17.5 0.5 0.026 14.8 0.0 2.6 2 2 0 2 2 2 1 AAA domain Ras PF00071.22 EFE41764.1 - 0.0051 16.4 0.0 0.021 14.4 0.0 2.1 1 1 0 1 1 1 1 Ras family AIG1 PF04548.16 EFE41764.1 - 0.0052 16.1 0.0 0.0052 16.1 0.0 2.3 2 0 0 2 2 2 1 AIG1 family AAA_29 PF13555.6 EFE41764.1 - 0.022 14.5 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFE41764.1 - 0.059 13.9 8.5 16 5.9 8.5 2.3 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EFE41764.1 - 0.073 13.1 8.2 1 9.4 0.0 3.8 4 1 0 4 4 2 0 Dynamin family AAA_24 PF13479.6 EFE41764.1 - 0.082 12.6 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 EFE41764.1 - 0.12 11.9 8.1 0.23 11.0 8.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit RNA_helicase PF00910.22 EFE41764.1 - 0.16 12.4 0.9 1.1 9.7 0.0 2.4 2 0 0 2 2 2 0 RNA helicase ATP_bind_1 PF03029.17 EFE41764.1 - 0.28 10.9 5.7 1.1 9.0 0.0 3.1 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein DUF87 PF01935.17 EFE41764.1 - 0.6 10.2 5.2 6.4 6.8 0.0 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain Atg14 PF10186.9 EFE41764.1 - 1.8 7.6 8.5 2.8 7.0 8.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2937 PF11157.8 EFE41764.1 - 4.7 6.9 8.7 0.49 10.1 4.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Strep_SA_rep PF06696.11 EFE41764.1 - 4.9 7.3 6.3 3 7.9 3.5 2.1 1 1 1 2 2 2 0 Streptococcal surface antigen repeat TMPIT PF07851.13 EFE41764.1 - 4.9 6.3 6.1 8.2 5.6 6.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein UPF0121 PF03661.13 EFE41766.1 - 3.2e-25 88.9 1.9 4.8e-25 88.4 1.9 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) FAM176 PF14851.6 EFE41766.1 - 0.015 15.0 0.0 0.015 15.0 0.0 2.8 2 1 1 3 3 3 0 FAM176 family 7TM_GPCR_Str PF10326.9 EFE41766.1 - 0.08 12.3 2.9 0.084 12.2 0.3 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str Mito_carr PF00153.27 EFE41767.1 - 1.4e-60 201.3 6.0 1.4e-20 73.0 1.2 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein CHCH PF06747.13 EFE41769.1 - 8.8e-07 28.9 5.3 1.5e-06 28.2 5.3 1.4 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 EFE41769.1 - 0.002 18.5 1.4 0.0046 17.4 1.4 1.7 1 0 0 1 1 1 1 GCK domain TPK_catalytic PF04263.16 EFE41770.1 - 1.8e-22 79.6 0.0 3.4e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EFE41770.1 - 4.1e-18 64.9 0.0 7.7e-18 64.0 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain MIF4G PF02854.19 EFE41772.1 - 2.7e-55 187.3 0.0 1.1e-29 103.6 0.0 3.8 4 0 0 4 4 4 2 MIF4G domain Upf2 PF04050.14 EFE41772.1 - 2.9e-35 122.0 13.5 2.9e-35 122.0 13.5 3.1 3 1 0 3 3 3 1 Up-frameshift suppressor 2 FliD_C PF07195.12 EFE41772.1 - 0.028 13.8 1.9 0.058 12.8 1.9 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus FMO-like PF00743.19 EFE41774.1 - 6.2e-16 57.9 0.1 4.5e-14 51.8 0.2 2.5 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFE41774.1 - 1.4e-11 44.2 0.0 8.5e-11 41.7 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFE41774.1 - 1.9e-09 37.6 0.0 4.1e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE41774.1 - 8.8e-07 28.4 0.0 0.00023 20.5 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE41774.1 - 7e-06 25.4 0.1 0.00099 18.3 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EFE41774.1 - 2e-05 24.4 0.0 0.00023 20.9 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFE41774.1 - 0.012 14.9 0.2 0.02 14.1 0.2 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 EFE41774.1 - 0.019 15.0 0.0 0.17 11.9 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EFE41774.1 - 0.025 13.7 0.3 0.036 13.2 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain MrpF_PhaF PF04066.13 EFE41774.1 - 0.038 14.4 0.0 0.075 13.4 0.0 1.5 1 0 0 1 1 1 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) FAD_oxidored PF12831.7 EFE41774.1 - 0.11 11.8 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EFE41774.1 - 0.15 12.2 0.1 27 4.8 0.0 2.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 EFE41774.1 - 0.47 9.1 1.4 0.84 8.3 1.4 1.3 1 0 0 1 1 1 0 HI0933-like protein Glyco_hydro_18 PF00704.28 EFE41775.1 - 3.3e-73 247.1 0.0 4.2e-73 246.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EFE41775.1 - 1.8e-12 47.1 0.1 3.8e-12 46.1 0.1 1.6 1 0 0 1 1 1 1 LysM domain GREB1 PF15782.5 EFE41776.1 - 4.3 4.3 10.0 5.8 3.9 10.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Glyco_transf_8 PF01501.20 EFE41777.1 - 4.4e-05 23.2 0.1 6e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 APH PF01636.23 EFE41778.1 - 9.8e-15 55.1 0.0 3.1e-14 53.5 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE41778.1 - 0.00066 18.6 0.0 0.21 10.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) SUN PF03856.13 EFE41779.1 - 3e-85 285.6 2.5 3.9e-85 285.2 2.5 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Ribosomal_L1 PF00687.21 EFE41780.1 - 2.1e-57 194.2 0.2 2.1e-57 194.2 0.2 1.5 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family ETF PF01012.21 EFE41781.1 - 4.9e-41 140.6 1.5 9.8e-41 139.6 1.5 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EFE41781.1 - 2.1e-33 114.2 0.1 5e-33 113.0 0.1 1.7 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Kdo PF06293.14 EFE41782.1 - 8e-07 28.6 0.0 1.7e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EFE41782.1 - 2.5e-05 23.8 0.0 7.9e-05 22.2 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFE41782.1 - 7.1e-05 22.8 0.1 7.1e-05 22.8 0.1 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EFE41782.1 - 0.019 14.5 0.3 0.051 13.1 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 EFE41782.1 - 0.034 13.8 0.0 0.089 12.4 0.0 1.7 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 EFE41782.1 - 0.057 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase AAA PF00004.29 EFE41784.1 - 6e-12 46.1 0.0 1.2e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFE41784.1 - 7.7e-06 25.9 0.0 1.6e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFE41784.1 - 8.7e-06 26.1 0.0 2.1e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EFE41784.1 - 9.9e-06 25.6 0.1 4.3e-05 23.5 0.0 1.9 1 1 1 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 EFE41784.1 - 1.5e-05 24.8 0.0 3.2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EFE41784.1 - 0.0016 18.5 0.0 0.0031 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFE41784.1 - 0.0016 18.6 0.0 0.0039 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFE41784.1 - 0.006 17.0 0.0 0.024 15.0 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.6 EFE41784.1 - 0.0065 16.8 1.0 0.096 13.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EFE41784.1 - 0.033 14.1 0.1 0.072 13.0 0.1 1.6 1 0 0 1 1 1 0 NTPase DUF1776 PF08643.10 EFE41784.1 - 0.043 13.2 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) TsaE PF02367.17 EFE41784.1 - 0.061 13.3 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EFE41784.1 - 0.11 11.8 0.0 0.11 11.8 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_24 PF13479.6 EFE41784.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFE41784.1 - 0.16 12.5 0.1 0.39 11.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFE41784.1 - 0.18 11.7 1.2 0.23 11.3 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_17 PF13207.6 EFE41784.1 - 0.37 11.2 0.0 0.37 11.2 0.0 2.2 2 0 0 2 2 1 0 AAA domain CENP-K PF11802.8 EFE41785.1 - 7.6e-05 22.4 2.0 0.00012 21.8 2.0 1.2 1 0 0 1 1 1 1 Centromere-associated protein K Baculo_PEP_C PF04513.12 EFE41785.1 - 0.0087 16.1 5.3 0.89 9.6 5.5 2.4 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Allexi_40kDa PF05549.11 EFE41785.1 - 0.013 15.0 3.8 0.27 10.7 0.2 2.3 1 1 0 2 2 2 0 Allexivirus 40kDa protein CinA_KH PF18146.1 EFE41785.1 - 0.03 14.5 0.1 0.17 12.1 0.1 2.1 1 1 1 2 2 2 0 Damage-inducible protein CinA KH domain EzrA PF06160.12 EFE41785.1 - 0.077 11.2 2.0 0.16 10.1 2.0 1.4 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Lebercilin PF15619.6 EFE41785.1 - 0.11 12.2 1.7 7 6.3 0.0 2.5 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Dynactin_p22 PF07426.11 EFE41785.1 - 0.11 12.3 3.8 0.27 11.1 3.8 1.7 1 1 0 1 1 1 0 Dynactin subunit p22 RSS_P20 PF11757.8 EFE41785.1 - 0.17 12.4 2.1 19 5.8 0.0 2.6 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain PriC PF07445.12 EFE41785.1 - 0.35 10.8 3.9 1.2 9.0 3.9 1.8 1 1 0 1 1 1 0 Primosomal replication protein priC ABC_tran_CTD PF16326.5 EFE41785.1 - 0.49 10.7 3.9 8.4 6.7 0.3 3.2 1 1 1 3 3 3 0 ABC transporter C-terminal domain BRE1 PF08647.11 EFE41785.1 - 0.54 10.4 4.1 32 4.7 3.8 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Cortex-I_coil PF09304.10 EFE41785.1 - 0.56 10.4 4.9 0.79 10.0 1.4 2.5 2 1 1 3 3 3 0 Cortexillin I, coiled coil BBP1_C PF15272.6 EFE41785.1 - 0.59 9.9 4.1 0.18 11.6 1.1 1.7 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal ATG16 PF08614.11 EFE41785.1 - 0.78 9.9 6.5 0.1 12.8 0.5 2.5 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Tropomyosin PF00261.20 EFE41785.1 - 1.3 8.3 7.1 0.61 9.4 2.0 2.1 1 1 1 2 2 2 0 Tropomyosin XhlA PF10779.9 EFE41785.1 - 5.2 7.3 5.8 23 5.3 1.0 3.0 3 0 0 3 3 3 0 Haemolysin XhlA SWIRM PF04433.17 EFE41786.1 - 6.2e-31 106.6 0.0 1.5e-30 105.3 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EFE41786.1 - 1.8e-30 104.8 8.5 4.9e-30 103.3 8.5 1.8 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EFE41786.1 - 1.4e-09 37.9 0.1 2.6e-09 37.1 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFE41786.1 - 6.1e-06 26.4 0.2 1.3e-05 25.3 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EFE41786.1 - 1.5 8.7 4.4 0.66 9.8 0.1 2.1 2 0 0 2 2 2 0 Zinc finger, ZZ type V_ATPase_I PF01496.19 EFE41787.1 - 0.46 8.3 2.9 0.86 7.4 2.9 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 EFE41787.1 - 9.7 5.9 16.5 20 4.9 16.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ResIII PF04851.15 EFE41788.1 - 1.6e-18 67.3 0.0 2.7e-15 56.8 0.0 2.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFE41788.1 - 3.3e-13 50.0 0.0 9.8e-13 48.4 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE41788.1 - 4.2e-06 26.6 0.0 0.014 15.2 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase UvrD-helicase PF00580.21 EFE41788.1 - 0.14 11.7 0.1 0.8 9.2 0.0 2.0 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain Ank_2 PF12796.7 EFE41790.1 - 2e-44 150.1 0.5 6.8e-13 49.0 0.0 5.0 3 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE41790.1 - 5e-26 90.7 5.0 7.4e-09 36.0 0.1 6.0 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE41790.1 - 5.4e-25 84.7 4.3 0.0037 17.7 0.1 8.4 7 1 1 8 8 8 7 Ankyrin repeat Ank PF00023.30 EFE41790.1 - 4e-17 61.8 4.3 0.0016 18.8 0.2 7.8 6 1 1 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EFE41790.1 - 9.9e-14 51.2 3.5 0.14 12.5 0.1 6.5 4 1 2 6 6 6 4 Ankyrin repeats (many copies) DUF3700 PF12481.8 EFE41790.1 - 0.098 12.1 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Aluminium induced protein DUF3447 PF11929.8 EFE41790.1 - 0.16 11.9 0.1 4.4 7.3 0.0 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3447) Glyco_transf_90 PF05686.12 EFE41792.1 - 5.9e-27 94.6 0.9 8e-27 94.2 0.9 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 PGAP1 PF07819.13 EFE41793.1 - 1.7e-84 283.2 0.0 2.6e-84 282.6 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EFE41793.1 - 6.8e-05 23.6 0.1 0.00019 22.1 0.1 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EFE41793.1 - 0.0007 19.5 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EFE41793.1 - 0.001 18.8 0.2 0.0024 17.5 0.2 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EFE41793.1 - 0.0029 17.3 0.0 0.0053 16.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 EFE41793.1 - 0.0066 15.7 0.0 0.014 14.6 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LCAT PF02450.15 EFE41793.1 - 0.007 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EFE41793.1 - 0.024 14.2 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Peptidase_M28 PF04389.17 EFE41794.1 - 2.6e-28 99.1 0.1 7.7e-28 97.5 0.1 1.7 1 1 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EFE41794.1 - 1.6e-07 31.3 0.0 2.1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EFE41794.1 - 0.00053 19.1 0.0 0.0012 17.9 0.0 1.7 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase fn3 PF00041.21 EFE41794.1 - 0.026 14.8 0.0 0.055 13.8 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain Nicastrin PF05450.15 EFE41794.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Nicastrin NAD_binding_10 PF13460.6 EFE41795.1 - 1e-10 41.8 0.0 4.1e-10 39.8 0.0 2.0 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFE41795.1 - 0.00021 20.9 0.2 0.0005 19.7 0.1 1.6 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 EFE41795.1 - 0.0071 15.8 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE41795.1 - 0.054 13.4 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 KR domain APG17 PF04108.12 EFE41797.1 - 2.2e-127 425.5 0.6 2.5e-127 425.3 0.6 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Tweety PF04906.13 EFE41797.1 - 0.025 13.3 1.1 0.15 10.7 0.0 2.4 3 0 0 3 3 3 0 Tweety DUF4795 PF16043.5 EFE41797.1 - 0.028 14.0 1.3 0.27 10.8 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) FRB_dom PF08771.11 EFE41797.1 - 0.046 14.1 0.1 0.46 10.9 0.0 2.6 1 1 1 2 2 2 0 FKBP12-rapamycin binding domain HD_2 PF12917.7 EFE41797.1 - 0.16 11.7 0.6 0.92 9.2 0.3 2.3 2 0 0 2 2 2 0 HD containing hydrolase-like enzyme Med4 PF10018.9 EFE41797.1 - 0.16 11.6 3.8 3.2 7.4 0.0 2.9 2 1 1 3 3 3 0 Vitamin-D-receptor interacting Mediator subunit 4 7TMR-HDED PF07697.11 EFE41797.1 - 1.9 8.5 7.4 7.8 6.5 6.2 2.5 1 1 0 1 1 1 0 7TM-HD extracellular WD40 PF00400.32 EFE41798.1 - 1.9e-46 155.1 20.8 5.7e-09 36.5 0.5 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.7 EFE41798.1 - 3.4e-14 52.5 0.3 7e-14 51.5 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE41798.1 - 1.4e-10 40.8 0.3 4e-10 39.3 0.1 1.9 2 0 0 2 2 2 1 F-box domain Nup160 PF11715.8 EFE41798.1 - 2.5e-10 39.6 7.1 0.028 13.1 0.2 5.7 5 1 1 6 6 6 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFE41798.1 - 2e-09 37.6 0.4 0.0014 18.9 0.0 4.7 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 EFE41798.1 - 0.0012 18.7 0.0 0.0036 17.2 0.0 1.8 1 0 0 1 1 1 1 F-box WD40_like PF17005.5 EFE41798.1 - 0.0028 17.0 0.1 0.0044 16.4 0.1 1.2 1 0 0 1 1 1 1 WD40-like domain CBP_BcsO PF17037.5 EFE41800.1 - 0.044 13.9 2.5 0.058 13.5 2.5 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsO Caskin-tail PF16632.5 EFE41801.1 - 0.038 14.4 2.2 0.27 11.7 0.1 2.7 2 0 0 2 2 2 0 C-terminal region of Caskin PTH2 PF01981.16 EFE41801.1 - 0.15 12.4 0.6 24 5.2 0.0 2.4 2 0 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 RIO1 PF01163.22 EFE41802.1 - 2.1e-72 242.7 0.1 2.1e-72 242.7 0.1 1.8 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EFE41802.1 - 2.7e-05 24.2 0.2 0.0062 16.5 0.1 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EFE41802.1 - 0.0027 17.1 0.6 0.033 13.6 0.6 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFE41802.1 - 0.084 12.5 0.8 0.19 11.3 0.2 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF3464 PF11947.8 EFE41802.1 - 0.21 11.4 2.6 0.53 10.0 2.6 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Kinase-PolyVal PF18762.1 EFE41802.1 - 0.28 11.1 1.6 0.55 10.2 0.1 2.2 3 0 0 3 3 3 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins Pkinase_fungal PF17667.1 EFE41802.1 - 0.67 8.7 4.6 0.1 11.4 0.4 1.7 2 0 0 2 2 2 0 Fungal protein kinase SMC_hinge PF06470.13 EFE41803.1 - 9.4e-32 109.8 0.1 6.3e-31 107.1 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.19 EFE41803.1 - 4.3e-29 101.5 24.7 1.1e-28 100.2 24.7 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFE41803.1 - 6.5e-15 56.2 4.5 6.5e-15 56.2 4.5 6.7 2 2 3 5 5 5 1 AAA domain AAA_21 PF13304.6 EFE41803.1 - 5.6e-07 29.7 10.9 7.1e-06 26.0 0.0 3.6 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFE41803.1 - 0.00092 19.0 16.1 0.00092 19.0 16.1 4.7 2 2 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EFE41803.1 - 0.0046 16.7 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain APG6_N PF17675.1 EFE41803.1 - 0.0074 16.8 136.8 0.05 14.1 7.4 8.3 4 2 4 8 8 8 3 Apg6 coiled-coil region FlaC_arch PF05377.11 EFE41803.1 - 0.099 13.0 0.1 0.099 13.0 0.1 8.8 10 2 1 11 11 11 0 Flagella accessory protein C (FlaC) ABC_tran PF00005.27 EFE41803.1 - 0.43 11.1 0.0 0.43 11.1 0.0 6.1 4 2 0 4 4 4 0 ABC transporter DUF87 PF01935.17 EFE41803.1 - 2.6 8.1 0.0 2.6 8.1 0.0 6.6 3 2 4 7 7 7 0 Helicase HerA, central domain DUF3605 PF12239.8 EFE41804.1 - 1.5e-57 194.2 0.1 1.7e-57 194.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Dfp1_Him1_M PF08630.10 EFE41804.1 - 0.11 12.7 0.0 0.77 10.0 0.0 2.0 2 0 0 2 2 2 0 Dfp1/Him1, central region FAD_binding_6 PF00970.24 EFE41805.1 - 4.2e-32 110.4 0.0 6.8e-32 109.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFE41805.1 - 3.4e-28 98.4 0.0 5.3e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFE41805.1 - 1.4e-05 25.2 0.0 0.0016 18.6 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain DUF4176 PF13780.6 EFE41805.1 - 0.016 15.2 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4176) FAD_binding_9 PF08021.11 EFE41805.1 - 0.058 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain WD40 PF00400.32 EFE41806.1 - 3.8e-11 43.3 18.0 0.00012 22.8 0.4 7.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE41806.1 - 0.0019 18.5 0.2 6.2 7.2 0.0 4.6 4 1 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE41806.1 - 0.15 11.0 0.2 0.55 9.1 0.0 2.0 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF3801 PF12687.7 EFE41806.1 - 1.2 9.2 5.3 2.1 8.4 5.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) tRNA-synt_1d PF00750.19 EFE41807.1 - 2.2e-95 319.6 8.7 1.3e-93 313.7 8.7 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFE41807.1 - 1.4e-27 96.3 0.0 3.5e-27 94.9 0.0 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EFE41807.1 - 0.0011 19.6 1.0 0.0044 17.6 0.0 2.6 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain DUF16 PF01519.16 EFE41807.1 - 0.032 14.7 4.2 0.22 12.0 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 EFE41807.1 - 0.22 12.0 2.0 0.31 11.6 0.4 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF5338 PF17273.2 EFE41808.1 - 0.045 13.8 0.2 0.56 10.3 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5338) RRN3 PF05327.11 EFE41809.1 - 0.57 8.7 5.3 0.93 8.0 5.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RPEL PF02755.15 EFE41809.1 - 1.6 8.6 6.2 0.98 9.2 1.9 3.0 3 0 0 3 3 3 0 RPEL repeat DUF3606 PF12244.8 EFE41811.1 - 0.085 12.8 0.0 0.45 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) Myc-LZ PF02344.15 EFE41811.1 - 4 7.6 8.5 1.1 9.4 1.8 2.8 2 0 0 2 2 2 0 Myc leucine zipper domain Dabb PF07876.12 EFE41812.1 - 7.5e-23 81.0 0.1 9.4e-23 80.7 0.1 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain ECD PF18432.1 EFE41812.1 - 0.08 12.9 0.0 0.15 12.0 0.0 1.5 1 1 0 1 1 1 0 Extracellular Cadherin domain NAD_binding_1 PF00175.21 EFE41813.1 - 1.5e-22 80.3 0.0 2e-22 79.9 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFE41813.1 - 5.3e-07 29.9 0.0 0.00064 19.9 0.0 2.1 2 0 0 2 2 2 2 Ferric reductase NAD binding domain DUF1206 PF06724.11 EFE41814.1 - 0.03 14.4 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) SR-25 PF10500.9 EFE41815.1 - 0.12 12.0 3.6 0.12 12.0 3.6 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MFS_1 PF07690.16 EFE41816.1 - 2.4e-34 118.8 15.6 7e-33 114.0 15.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE41816.1 - 1.7e-09 37.0 2.3 3.9e-09 35.9 2.3 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter Abhydrolase_6 PF12697.7 EFE41817.1 - 1.8e-17 64.7 5.2 1.1e-16 62.2 5.2 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFE41817.1 - 0.04 13.6 0.0 0.094 12.3 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold WD40 PF00400.32 EFE41818.1 - 2.1e-15 56.8 14.8 0.0053 17.6 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Ccdc124 PF06244.12 EFE41819.1 - 4.2e-28 98.5 22.3 4.2e-28 98.5 22.3 2.3 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 F-box-like PF12937.7 EFE41820.1 - 2.7e-07 30.4 0.3 5.5e-07 29.4 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE41820.1 - 8.7e-07 28.7 0.5 8.7e-07 28.7 0.5 2.7 3 0 0 3 3 3 1 F-box domain F-box_4 PF15966.5 EFE41820.1 - 0.0035 17.2 0.1 0.0087 15.9 0.1 1.7 1 0 0 1 1 1 1 F-box Peptidase_C13 PF01650.18 EFE41821.1 - 5.5e-41 140.8 0.0 7.9e-41 140.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase C13 family CDC45 PF02724.14 EFE41822.1 - 3.6e-238 792.1 0.0 4.3e-237 788.5 0.0 2.8 1 1 0 1 1 1 1 CDC45-like protein Cwf_Cwc_15 PF04889.12 EFE41822.1 - 0.32 10.7 17.3 0.086 12.6 6.9 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Trypan_PARP PF05887.11 EFE41822.1 - 0.51 10.3 7.7 1.1 9.2 0.9 3.0 3 0 0 3 3 3 0 Procyclic acidic repetitive protein (PARP) BUD22 PF09073.10 EFE41822.1 - 0.55 9.5 28.2 0.23 10.7 11.6 2.1 2 0 0 2 2 2 0 BUD22 FAM60A PF15396.6 EFE41822.1 - 1 9.3 5.6 0.14 12.1 1.5 1.6 2 0 0 2 2 2 0 Protein Family FAM60A CSRNP_N PF16019.5 EFE41822.1 - 1.9 8.4 6.5 4.1 7.3 6.5 1.5 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Med5 PF08689.10 EFE41822.1 - 7.1 4.3 5.4 9.9 3.8 5.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit Med5 Acetyltransf_7 PF13508.7 EFE41823.1 - 6.4e-09 36.1 0.0 1.1e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFE41823.1 - 1.7e-08 34.5 0.0 2.6e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE41823.1 - 2.4e-07 31.0 0.0 4.3e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFE41823.1 - 2.2e-05 24.4 0.0 3.9e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EFE41823.1 - 0.002 18.2 0.4 0.34 11.0 0.0 2.5 2 1 1 3 3 3 2 Acetyltransferase (GNAT) domain Condensation PF00668.20 EFE41824.1 - 1.2e-05 24.2 0.0 1.6e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Condensation domain ABC_tran PF00005.27 EFE41826.1 - 3.6e-47 160.3 0.4 2.4e-25 89.7 0.1 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFE41826.1 - 1.8e-27 96.7 32.3 2.9e-23 82.9 17.2 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EFE41826.1 - 4.4e-09 36.1 6.2 0.0018 17.8 0.1 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFE41826.1 - 2.9e-08 33.9 6.3 0.0096 15.8 0.1 4.3 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFE41826.1 - 6.8e-07 30.0 0.4 0.001 19.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFE41826.1 - 1e-06 28.8 0.4 0.0012 18.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EFE41826.1 - 1.3e-06 28.1 0.7 0.0087 15.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFE41826.1 - 3.5e-05 24.3 0.3 0.044 14.2 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EFE41826.1 - 6.9e-05 22.9 0.2 0.17 12.0 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_24 PF13479.6 EFE41826.1 - 0.00015 21.6 0.1 4.1 7.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 EFE41826.1 - 0.00015 22.1 0.0 0.045 14.1 0.0 2.9 2 2 1 3 3 2 1 AAA domain AAA PF00004.29 EFE41826.1 - 0.00062 20.2 1.0 0.11 12.9 0.1 3.4 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFE41826.1 - 0.0011 19.2 4.5 0.23 11.8 0.4 3.1 3 0 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EFE41826.1 - 0.0015 18.3 0.9 0.032 13.9 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 EFE41826.1 - 0.0049 16.6 0.6 0.56 9.9 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 EFE41826.1 - 0.0057 15.9 1.4 0.7 9.0 0.5 2.7 2 1 0 2 2 2 1 NB-ARC domain ATPase_2 PF01637.18 EFE41826.1 - 0.006 16.5 0.2 0.43 10.4 0.1 2.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea T2SSE PF00437.20 EFE41826.1 - 0.0064 15.6 0.2 0.18 10.8 0.0 2.7 3 0 0 3 3 3 1 Type II/IV secretion system protein DUF815 PF05673.13 EFE41826.1 - 0.0067 15.6 0.1 0.72 9.0 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFE41826.1 - 0.0071 15.9 0.2 1.3 8.5 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_30 PF13604.6 EFE41826.1 - 0.0083 15.9 0.1 1.9 8.2 0.0 3.0 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFE41826.1 - 0.011 16.1 0.2 2.3 8.7 0.0 3.2 3 0 0 3 3 2 0 RNA helicase Dynamin_N PF00350.23 EFE41826.1 - 0.018 15.1 2.4 0.2 11.7 0.0 2.6 3 0 0 3 3 2 0 Dynamin family MeaB PF03308.16 EFE41826.1 - 0.026 13.5 0.7 1.1 8.2 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_10 PF12846.7 EFE41826.1 - 0.029 13.3 1.0 4.1 6.2 0.1 2.6 2 1 1 3 3 3 0 AAA-like domain NTPase_1 PF03266.15 EFE41826.1 - 0.039 13.9 2.4 5.6 6.8 0.1 2.7 2 0 0 2 2 2 0 NTPase Adeno_IVa2 PF02456.15 EFE41826.1 - 0.046 12.5 0.4 0.18 10.5 0.0 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein Zeta_toxin PF06414.12 EFE41826.1 - 0.047 13.0 0.1 3.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_14 PF13173.6 EFE41826.1 - 0.047 13.7 0.2 0.56 10.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 EFE41826.1 - 0.1 12.3 7.9 12 5.5 0.1 4.3 5 0 0 5 5 4 0 IstB-like ATP binding protein ABC_ATPase PF09818.9 EFE41826.1 - 0.11 11.3 2.1 1.2 7.9 0.1 2.7 3 0 0 3 3 3 0 Predicted ATPase of the ABC class AAA_18 PF13238.6 EFE41826.1 - 0.12 13.0 0.1 6.3 7.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFE41826.1 - 0.12 11.9 0.3 1.8 8.1 0.1 2.3 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EFE41826.1 - 0.13 12.5 0.4 51 4.1 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 EFE41826.1 - 0.13 11.9 0.1 11 5.6 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 EFE41826.1 - 0.23 10.8 1.0 8.2 5.7 0.1 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 EFE41826.1 - 0.31 10.6 7.3 0.37 10.4 1.0 2.8 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EFE41826.1 - 0.54 10.4 1.9 6.6 6.9 0.1 3.0 3 0 0 3 3 2 0 AAA domain DUF87 PF01935.17 EFE41826.1 - 0.55 10.3 3.8 1.6 8.8 0.5 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain NACHT PF05729.12 EFE41826.1 - 0.58 10.1 5.5 0.77 9.7 0.0 3.2 4 0 0 4 4 3 0 NACHT domain Rad17 PF03215.15 EFE41826.1 - 1.8 8.5 5.2 0.81 9.6 0.3 2.6 3 0 0 3 3 3 0 Rad17 P-loop domain UCR_UQCRX_QCR9 PF05365.12 EFE41826.1 - 6.1 6.9 7.2 0.61 10.1 1.9 2.0 2 0 0 2 2 1 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Fungal_trans_2 PF11951.8 EFE41827.1 - 9.2e-49 166.2 0.1 2.9e-48 164.6 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE41827.1 - 0.00012 22.1 5.4 0.00024 21.2 5.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zip PF02535.22 EFE41829.1 - 2.7 7.1 8.3 3 7.0 8.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 EFE41829.1 - 5.1 5.8 12.9 5.5 5.7 12.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MFS_1 PF07690.16 EFE41830.1 - 2.8e-30 105.4 22.6 2.9e-30 105.4 21.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily adh_short PF00106.25 EFE41831.1 - 3.5e-12 46.2 0.0 4.3e-12 45.9 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE41831.1 - 1.8e-09 37.5 0.0 2.2e-09 37.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE41831.1 - 0.00028 20.8 0.0 0.00033 20.6 0.0 1.0 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EFE41831.1 - 0.062 12.8 0.1 0.074 12.6 0.1 1.1 1 0 0 1 1 1 0 NmrA-like family NAD_binding_10 PF13460.6 EFE41831.1 - 0.065 13.1 0.0 0.08 12.8 0.0 1.1 1 0 0 1 1 1 0 NAD(P)H-binding Amino_oxidase PF01593.24 EFE41832.1 - 1.8e-56 192.3 0.2 4.2e-56 191.1 0.2 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFE41832.1 - 0.038 14.2 0.0 0.097 12.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HTH_ABP1_N PF18107.1 EFE41832.1 - 0.16 11.7 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain DUF1269 PF06897.12 EFE41833.1 - 0.086 13.1 0.0 11 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) BPS PF08947.10 EFE41835.1 - 0.38 10.6 3.1 0.84 9.5 0.4 2.3 1 1 1 2 2 2 0 BPS (Between PH and SH2) FoP_duplication PF13865.6 EFE41836.1 - 2e-05 25.1 1.0 3.4e-05 24.3 1.0 1.3 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 EFE41836.1 - 0.00012 21.8 0.0 0.0002 21.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_60s PF00428.19 EFE41836.1 - 4.8 7.8 8.4 12 6.6 3.2 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Ank_2 PF12796.7 EFE41838.1 - 3e-77 255.3 0.4 5.1e-16 59.0 0.6 8.1 3 2 3 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE41838.1 - 3e-58 193.5 1.3 8.3e-12 45.4 0.0 11.2 7 2 5 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE41838.1 - 5.3e-48 155.4 3.0 4.5e-05 23.5 0.0 15.5 17 0 0 17 17 16 8 Ankyrin repeat Ank PF00023.30 EFE41838.1 - 1.2e-41 139.3 9.6 2e-05 24.8 0.0 13.3 14 0 0 14 14 13 7 Ankyrin repeat Ank_5 PF13857.6 EFE41838.1 - 5.6e-37 125.3 3.5 6.8e-07 29.5 0.0 11.3 4 2 7 13 13 13 6 Ankyrin repeats (many copies) HeLo PF14479.6 EFE41838.1 - 5.7e-17 62.2 1.7 5.7e-16 59.0 0.0 2.8 2 1 0 2 2 2 1 Prion-inhibition and propagation NACHT PF05729.12 EFE41838.1 - 5.1e-08 33.0 0.0 1.1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFE41838.1 - 2.1e-05 24.8 0.0 8.3e-05 22.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EFE41838.1 - 4.6e-05 22.7 0.3 0.00014 21.2 0.3 1.6 1 1 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EFE41838.1 - 0.00012 22.5 0.0 0.00032 21.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 EFE41838.1 - 0.0034 17.7 0.0 0.0085 16.5 0.0 1.7 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 EFE41838.1 - 0.0062 16.5 0.1 0.046 13.6 0.0 2.3 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea VWA_3_C PF18571.1 EFE41838.1 - 0.1 12.5 0.0 1.4 8.9 0.1 2.7 2 0 0 2 2 2 0 von Willebrand factor type A C-terminal domain Sigma54_activ_2 PF14532.6 EFE41838.1 - 0.15 12.2 0.2 5.2 7.2 0.0 3.2 3 0 0 3 3 3 0 Sigma-54 interaction domain ATP_bind_1 PF03029.17 EFE41838.1 - 0.16 11.7 0.0 0.39 10.5 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EFE41838.1 - 0.17 11.4 0.0 0.38 10.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NUMOD4 PF07463.11 EFE41838.1 - 0.2 11.9 0.2 0.88 9.8 0.0 2.2 2 0 0 2 2 2 0 NUMOD4 motif Glyco_hydro_72 PF03198.14 EFE41839.1 - 6e-111 370.7 0.4 8.1e-111 370.3 0.4 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EFE41839.1 - 1.5e-05 24.6 0.0 0.00037 20.0 0.0 2.2 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) MAS20 PF02064.15 EFE41840.1 - 3.5e-26 91.8 0.2 4e-26 91.6 0.2 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor Exo84_C PF16528.5 EFE41841.1 - 2.5e-68 229.9 0.1 2.5e-68 229.9 0.1 2.1 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EFE41841.1 - 5.2e-16 58.5 1.9 5.2e-16 58.5 1.9 2.1 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.11 EFE41841.1 - 0.0038 17.3 0.1 0.0038 17.3 0.1 2.6 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF2594 PF10769.9 EFE41841.1 - 0.027 14.5 0.1 0.059 13.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2594) DUF3275 PF11679.8 EFE41841.1 - 0.048 13.6 0.9 6.3 6.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) 7TMR-HDED PF07697.11 EFE41841.1 - 0.071 13.2 7.8 0.1 12.7 3.2 2.2 2 0 0 2 2 2 0 7TM-HD extracellular DUF4088 PF13317.6 EFE41841.1 - 0.18 11.3 2.2 0.47 10.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4088) DUF4407 PF14362.6 EFE41841.1 - 0.51 9.6 8.6 0.24 10.7 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 EFE41841.1 - 2.9 7.9 5.6 0.81 9.7 0.5 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HIP1_clath_bdg PF16515.5 EFE41841.1 - 3 8.5 10.3 1.4 9.5 3.0 2.8 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MscS_porin PF12795.7 EFE41841.1 - 9.1 5.7 12.4 2.3 7.7 6.5 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain ABC_tran PF00005.27 EFE41842.1 - 7.7e-21 75.1 0.0 8.3e-10 39.3 0.0 2.9 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFE41842.1 - 4.9e-06 26.6 3.9 0.0031 17.4 0.0 2.7 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EFE41842.1 - 0.00025 21.2 0.0 0.041 14.1 0.0 2.6 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 EFE41842.1 - 0.02 14.1 0.0 2.4 7.3 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Ploopntkinase1 PF18748.1 EFE41842.1 - 0.12 11.9 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 AAA_23 PF13476.6 EFE41842.1 - 1.1 9.8 2.6 0.91 10.0 0.7 1.8 2 0 0 2 2 2 0 AAA domain CPSase_L_D2 PF02786.17 EFE41843.1 - 2e-114 380.3 0.2 6.6e-83 277.4 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EFE41843.1 - 6e-49 165.1 0.0 1.3e-48 164.1 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EFE41843.1 - 1.3e-46 158.8 0.0 6.5e-46 156.5 0.0 2.2 2 0 0 2 2 2 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 EFE41843.1 - 7.6e-46 155.8 0.1 1.7e-45 154.6 0.1 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 EFE41843.1 - 8e-39 132.7 0.0 1.8e-38 131.7 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EFE41843.1 - 2e-25 89.7 0.0 5.2e-25 88.3 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 EFE41843.1 - 3.1e-22 78.6 0.0 1.4e-21 76.5 0.0 2.3 2 0 0 2 2 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 EFE41843.1 - 4.3e-18 65.6 0.3 2.3e-09 37.1 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EFE41843.1 - 1.2e-15 57.5 0.1 7.5e-08 32.1 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EFE41843.1 - 2.5e-10 40.2 0.0 4e-05 23.4 0.0 2.9 3 0 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 EFE41843.1 - 5.1e-06 26.6 0.5 0.021 14.9 0.1 3.0 3 0 0 3 3 3 2 ATP-grasp domain Peptidase_C26 PF07722.13 EFE41843.1 - 6.2e-05 22.9 0.1 0.0055 16.5 0.1 2.8 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 EFE41843.1 - 0.00046 20.0 0.2 0.22 11.3 0.0 4.0 5 0 0 5 5 4 1 DJ-1/PfpI family RimK PF08443.11 EFE41843.1 - 0.0017 18.0 0.0 1.6 8.3 0.0 2.6 2 0 0 2 2 2 2 RimK-like ATP-grasp domain GARS_A PF01071.19 EFE41843.1 - 0.0082 15.9 0.1 1.8 8.3 0.0 2.8 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain TrkA_N PF02254.18 EFE41843.1 - 0.11 12.7 0.0 0.68 10.2 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain DUF2079 PF09852.9 EFE41844.1 - 0.053 12.4 0.3 0.065 12.1 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) Ycf9 PF01737.17 EFE41844.1 - 0.085 12.7 1.4 0.17 11.8 1.4 1.5 1 0 0 1 1 1 0 YCF9 Ion_trans PF00520.31 EFE41845.1 - 1.5e-08 34.2 28.0 2.3e-08 33.6 28.0 1.2 1 0 0 1 1 1 1 Ion transport protein Synaptobrevin PF00957.21 EFE41846.1 - 3.2e-32 110.2 0.0 3.8e-32 109.9 0.0 1.1 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFE41846.1 - 0.00047 20.1 0.1 0.00069 19.6 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain CCSMST1 PF15013.6 EFE41846.1 - 0.14 12.4 0.1 0.24 11.6 0.1 1.3 1 0 0 1 1 1 0 CCSMST1 family Dynactin PF12455.8 EFE41846.1 - 0.16 11.2 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Dynein associated protein Prominin PF05478.11 EFE41846.1 - 0.34 8.8 0.3 0.85 7.5 0.4 1.4 1 1 1 2 2 2 0 Prominin Ribosomal_L26 PF16906.5 EFE41847.1 - 3.8e-39 133.0 3.0 4.7e-39 132.7 3.0 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EFE41847.1 - 9.7e-09 34.9 2.1 2e-08 33.9 2.1 1.6 1 0 0 1 1 1 1 KOW motif DUF1223 PF06764.11 EFE41847.1 - 0.011 15.8 0.1 0.012 15.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) DFRP_C PF16543.5 EFE41849.1 - 1e-25 90.0 9.6 1e-25 90.0 9.6 3.4 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 EFE41849.1 - 4.3e-06 27.4 4.2 4.3e-06 27.4 4.2 3.9 2 2 2 4 4 4 2 Torus domain zf-CCCH_4 PF18044.1 EFE41849.1 - 7.6e-05 22.4 10.2 0.00092 19.0 2.7 3.2 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH PF00642.24 EFE41849.1 - 0.00035 20.4 1.3 0.00035 20.4 1.3 2.7 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFE41849.1 - 0.0013 18.7 6.7 0.0013 18.7 6.7 3.3 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_3 PF15663.5 EFE41849.1 - 0.13 12.5 6.3 0.65 10.2 1.0 2.6 1 1 0 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 EFE41849.1 - 0.36 11.4 14.8 0.34 11.4 4.4 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Snf7 PF03357.21 EFE41851.1 - 2.6e-20 72.7 15.2 2.8e-20 72.6 12.7 1.9 1 1 1 2 2 2 1 Snf7 PTE PF02126.18 EFE41851.1 - 0.069 12.6 0.0 0.17 11.3 0.0 1.6 2 0 0 2 2 2 0 Phosphotriesterase family Mre11_DNA_bind PF04152.14 EFE41853.1 - 2.7e-53 180.8 0.5 5.4e-53 179.8 0.5 1.5 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EFE41853.1 - 5.7e-11 43.3 0.3 3.5e-10 40.7 0.3 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase CHIP_TPR_N PF18391.1 EFE41853.1 - 2.3 9.0 7.4 0.2 12.5 1.2 2.3 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain GDPD PF03009.17 EFE41854.1 - 0.084 12.6 0.1 0.4 10.4 0.0 1.9 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family GST_C PF00043.25 EFE41855.1 - 7.1e-15 55.0 0.0 1.4e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFE41855.1 - 9.1e-11 42.0 0.0 1.9e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFE41855.1 - 2.7e-10 40.5 0.0 5.1e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE41855.1 - 2e-09 37.6 0.0 3.6e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFE41855.1 - 4.2e-09 36.5 0.0 7.6e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE41855.1 - 4.6e-08 33.0 0.0 8.7e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Aldedh PF00171.22 EFE41856.1 - 5.7e-184 611.9 0.1 6.7e-184 611.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Atrophin-1 PF03154.15 EFE41856.1 - 0.22 9.7 0.7 0.3 9.3 0.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family Metallophos PF00149.28 EFE41857.1 - 4.1e-24 86.2 0.0 6.2e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EFE41857.1 - 0.0019 17.8 0.0 0.0028 17.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain DIOX_N PF14226.6 EFE41858.1 - 3.9e-09 37.3 0.0 7.8e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFE41858.1 - 6.6e-06 26.6 0.0 0.00052 20.5 0.0 2.3 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily Ctr PF04145.15 EFE41859.1 - 3.7e-30 105.5 0.0 4.3e-30 105.3 0.0 1.0 1 0 0 1 1 1 1 Ctr copper transporter family Smg4_UPF3 PF03467.15 EFE41860.1 - 1.8e-41 142.0 0.0 1.8e-41 142.0 0.0 3.1 3 2 0 3 3 3 1 Smg-4/UPF3 family RRM_1 PF00076.22 EFE41860.1 - 7.1e-09 35.4 0.0 9.2e-08 31.8 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AbiJ_NTD3 PF18860.1 EFE41860.1 - 0.023 14.2 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 AbiJ N-terminal domain 3 zf-C2H2 PF00096.26 EFE41862.1 - 2.2e-09 37.2 11.5 0.00021 21.6 4.7 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE41862.1 - 8.4e-06 26.0 13.3 1.3e-05 25.4 2.3 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE41862.1 - 7.6e-05 23.2 13.4 0.019 15.7 2.5 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFE41862.1 - 0.0011 18.9 5.4 0.32 11.1 0.8 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFE41862.1 - 0.0018 18.5 4.2 0.74 10.2 0.1 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFE41862.1 - 0.0083 16.5 4.7 0.65 10.5 1.1 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2HE PF16278.5 EFE41862.1 - 0.38 11.2 7.7 2.6 8.6 1.4 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger p450 PF00067.22 EFE41863.1 - 2.4e-62 211.2 0.0 3.3e-62 210.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DivIC PF04977.15 EFE41864.1 - 0.15 11.8 0.1 0.15 11.8 0.1 2.0 2 0 0 2 2 2 0 Septum formation initiator GATA PF00320.27 EFE41865.1 - 1.4e-14 53.4 1.3 1.4e-14 53.4 1.3 1.8 2 0 0 2 2 2 1 GATA zinc finger DUF1752 PF08550.10 EFE41865.1 - 2.9e-12 46.2 1.4 5.7e-12 45.3 1.4 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) TF_Zn_Ribbon PF08271.12 EFE41865.1 - 0.13 11.8 0.2 0.28 10.7 0.2 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Aldedh PF00171.22 EFE41866.1 - 2.2e-103 346.3 0.1 2.6e-103 346.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family OCD_Mu_crystall PF02423.15 EFE41867.1 - 1.3e-10 40.7 0.0 1.1e-08 34.4 0.0 2.7 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EFE41867.1 - 9.8e-05 22.4 0.0 0.11 12.5 0.0 2.6 1 1 1 2 2 2 2 Shikimate / quinate 5-dehydrogenase Amino_oxidase PF01593.24 EFE41869.1 - 2.1e-26 93.3 0.0 4.6e-26 92.1 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase LEA_6 PF10714.9 EFE41870.1 - 0.21 11.7 2.8 1.5 8.9 0.9 2.7 2 0 0 2 2 2 0 Late embryogenesis abundant protein 18 Metallophos_2 PF12850.7 EFE41871.1 - 1.6e-06 28.4 0.1 7.6e-05 23.0 0.1 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EFE41871.1 - 2.1e-06 28.4 0.1 2.8e-06 28.0 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF2183 PF09949.9 EFE41872.1 - 6.1e-32 109.9 0.0 2.2e-31 108.1 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) HrpB2 PF09487.10 EFE41872.1 - 0.002 18.5 0.2 0.0073 16.7 0.2 1.9 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB2) CarboxypepD_reg PF13620.6 EFE41872.1 - 0.028 14.7 0.1 0.3 11.4 0.0 2.5 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain RPAP1_N PF08621.10 EFE41872.1 - 0.1 12.4 2.4 0.2 11.4 2.4 1.5 1 0 0 1 1 1 0 RPAP1-like, N-terminal PI31_Prot_N PF11566.8 EFE41873.1 - 7.3e-37 126.7 0.0 1.1e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EFE41873.1 - 1.7e-18 67.5 13.3 1.7e-18 67.5 13.3 3.0 4 0 0 4 4 4 1 PI31 proteasome regulator Metallophos PF00149.28 EFE41874.1 - 1.3e-37 130.3 0.4 1.5e-37 130.1 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EFE41874.1 - 0.071 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF1330 PF07045.11 EFE41874.1 - 0.15 12.4 0.0 0.25 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) adh_short_C2 PF13561.6 EFE41875.1 - 2.4e-49 168.0 0.5 3e-49 167.7 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE41875.1 - 1.5e-44 151.8 0.4 1.8e-44 151.5 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE41875.1 - 1.1e-10 41.8 0.1 1.5e-10 41.2 0.1 1.1 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EFE41875.1 - 0.015 14.6 0.1 0.023 14.0 0.1 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 EFE41875.1 - 0.023 14.1 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) 2-Hacid_dh_C PF02826.19 EFE41875.1 - 0.024 14.0 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EFE41875.1 - 0.096 12.7 0.2 0.17 12.0 0.2 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EFE41875.1 - 0.19 12.3 1.6 0.2 12.2 0.2 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF3112 PF11309.8 EFE41876.1 - 2e-10 40.5 11.2 2.4e-09 37.0 0.6 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF3112) DUF1180 PF06679.12 EFE41876.1 - 0.27 11.6 0.6 32 4.9 1.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Phage_Gp23 PF10669.9 EFE41876.1 - 3.8 7.9 4.3 1.3 9.4 0.4 2.1 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) TPR_1 PF00515.28 EFE41877.1 - 9.4e-08 31.6 0.5 0.00034 20.3 0.0 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFE41877.1 - 8.1e-06 25.6 0.3 0.03 14.4 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE41877.1 - 7.2e-05 22.4 0.1 0.00022 20.8 0.1 1.9 1 0 0 1 1 1 1 TPR repeat TPR_12 PF13424.6 EFE41877.1 - 9.5e-05 22.6 0.6 0.0002 21.6 0.1 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFE41877.1 - 0.00056 19.7 0.9 0.13 12.3 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFE41877.1 - 0.0067 17.2 0.2 0.23 12.4 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFE41877.1 - 0.082 13.4 0.0 0.29 11.7 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat eIF-3c_N PF05470.12 EFE41877.1 - 0.11 10.8 0.0 0.16 10.2 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Pkinase PF00069.25 EFE41878.1 - 3.1e-24 85.7 0.0 1.2e-14 54.4 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41878.1 - 2.3e-12 46.7 0.0 2.4e-08 33.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PTR2 PF00854.21 EFE41880.1 - 9.7e-92 307.8 9.8 1.5e-91 307.1 9.8 1.3 1 0 0 1 1 1 1 POT family Glyco_hydro_18 PF00704.28 EFE41881.1 - 3.7e-76 256.8 0.4 5.3e-76 256.3 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 ubiquitin PF00240.23 EFE41882.1 - 5.7e-34 115.7 0.7 9.7e-34 115.0 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 EFE41882.1 - 1.5e-26 92.3 1.9 1.5e-26 92.3 1.9 1.9 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EFE41882.1 - 4.1e-16 58.6 0.8 7.4e-16 57.7 0.8 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFE41882.1 - 2.5e-05 24.7 0.2 0.00013 22.4 0.2 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFE41882.1 - 0.00085 19.4 0.6 0.0019 18.3 0.6 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFE41882.1 - 0.0061 16.5 0.0 0.009 15.9 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFE41882.1 - 0.0081 16.5 0.9 0.013 15.8 0.1 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 EFE41882.1 - 0.0086 16.6 0.9 0.012 16.1 0.9 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain IBR PF01485.21 EFE41882.1 - 0.013 15.7 0.3 0.021 15.0 0.3 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Ubiquitin_4 PF18036.1 EFE41882.1 - 0.023 14.7 1.1 6.1 7.0 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain zf-H2C2_2 PF13465.6 EFE41883.1 - 1.9e-09 37.5 5.1 0.0013 19.1 0.1 3.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EFE41883.1 - 3.1e-07 30.5 17.1 0.00099 19.4 4.7 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE41883.1 - 5.9e-06 26.7 14.7 0.0071 17.1 3.4 4.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFE41883.1 - 0.051 13.6 7.1 1.3 9.1 2.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EFE41883.1 - 0.16 11.8 7.2 0.085 12.6 2.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 EFE41883.1 - 0.27 11.7 2.1 0.74 10.3 2.1 1.7 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 EFE41883.1 - 1.3 9.1 6.6 1.7 8.7 3.7 2.4 1 1 1 2 2 2 0 BED zinc finger zf-LYAR PF08790.11 EFE41883.1 - 7 6.6 9.0 30 4.6 0.0 3.7 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger DUF155 PF02582.14 EFE41884.1 - 1.1e-50 172.2 0.0 1.5e-50 171.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Clathrin PF00637.20 EFE41885.1 - 9.4e-19 67.7 0.0 3.8e-18 65.7 0.0 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS WD40 PF00400.32 EFE41885.1 - 0.093 13.6 0.5 81 4.3 0.0 4.0 2 1 0 2 2 2 0 WD domain, G-beta repeat Vps39_1 PF10366.9 EFE41885.1 - 0.15 12.4 0.1 0.52 10.6 0.0 1.9 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 DDOST_48kD PF03345.14 EFE41888.1 - 1e-158 528.5 0.0 1.2e-158 528.3 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Pet191_N PF10203.9 EFE41889.1 - 0.27 11.5 0.8 0.4 11.0 0.8 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Abhydrolase_1 PF00561.20 EFE41890.1 - 6.9e-25 88.2 0.1 6.5e-24 85.0 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EFE41890.1 - 4.7e-24 83.7 0.1 9.7e-24 82.7 0.1 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region FSH1 PF03959.13 EFE41890.1 - 0.00021 21.0 0.0 0.35 10.5 0.0 2.2 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 EFE41890.1 - 0.00047 19.5 0.0 0.045 13.0 0.0 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EFE41890.1 - 0.047 13.5 0.2 7.1 6.4 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Pyr_redox_2 PF07992.14 EFE41891.1 - 3.1e-37 128.4 0.0 4.5e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE41891.1 - 1.7e-15 57.3 0.0 2e-11 44.3 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE41891.1 - 9.7e-06 24.9 0.0 0.00029 20.1 0.0 2.3 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EFE41891.1 - 1.4e-05 24.5 0.0 0.0001 21.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFE41891.1 - 8.2e-05 21.6 0.0 0.16 10.8 0.0 2.9 3 0 0 3 3 3 2 Tryptophan halogenase Lycopene_cycl PF05834.12 EFE41891.1 - 0.014 14.5 0.0 3 6.8 0.0 2.4 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 EFE41891.1 - 0.024 14.2 0.0 3.8 7.0 0.0 2.7 3 0 0 3 3 3 0 FAD dependent oxidoreductase Eno-Rase_NADH_b PF12242.8 EFE41891.1 - 0.025 14.3 0.0 0.097 12.4 0.0 1.9 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_9 PF13454.6 EFE41891.1 - 0.026 14.5 0.0 62 3.5 0.0 3.8 4 0 0 4 4 4 0 FAD-NAD(P)-binding DUF1188 PF06690.11 EFE41891.1 - 0.057 13.0 0.0 0.31 10.5 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1188) PRT_C PF08372.10 EFE41891.1 - 0.093 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal TrkA_N PF02254.18 EFE41891.1 - 0.095 13.0 0.0 5.6 7.2 0.0 2.5 2 0 0 2 2 2 0 TrkA-N domain Metallophos PF00149.28 EFE41892.1 - 1.2e-14 55.3 0.9 1.7e-14 54.8 0.9 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFE41892.1 - 5.5e-07 29.9 0.2 1.1e-05 25.7 0.2 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EFE41892.1 - 0.00032 20.1 0.0 0.059 12.7 0.0 2.4 2 1 0 2 2 2 2 Metallophosphoesterase, calcineurin superfamily MutL PF13941.6 EFE41892.1 - 0.022 13.4 0.0 0.033 12.8 0.0 1.1 1 0 0 1 1 1 0 MutL protein Ribosomal_L13 PF00572.18 EFE41893.1 - 0.017 15.4 0.0 0.15 12.3 0.0 1.9 1 1 1 2 2 2 0 Ribosomal protein L13 AMP-binding PF00501.28 EFE41895.1 - 8.7e-65 219.0 0.0 1.3e-33 116.2 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EFE41895.1 - 2.6e-16 60.4 0.0 6.2e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LysR_substrate PF03466.20 EFE41895.1 - 0.018 14.4 0.0 0.035 13.5 0.0 1.5 1 0 0 1 1 1 0 LysR substrate binding domain LRR_6 PF13516.6 EFE41896.1 - 2.1e-12 46.1 22.6 0.35 11.0 0.0 12.3 13 0 0 13 13 13 3 Leucine Rich repeat F-box-like PF12937.7 EFE41896.1 - 2.5e-09 36.9 1.4 2.5e-09 36.9 1.4 3.0 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 EFE41896.1 - 1.2e-08 35.1 14.2 2.7 8.5 0.0 7.9 3 2 2 7 7 7 5 Leucine Rich repeats (2 copies) F-box PF00646.33 EFE41896.1 - 0.0015 18.3 9.0 0.0022 17.8 2.1 3.4 3 0 0 3 3 3 1 F-box domain BET PF17035.5 EFE41896.1 - 0.18 12.0 0.0 0.6 10.3 0.0 2.0 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation Peptidase_M28 PF04389.17 EFE41897.1 - 7.6e-35 120.4 0.0 1.3e-34 119.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 ATP-synt_8 PF00895.20 EFE41897.1 - 0.077 13.5 0.0 0.077 13.5 0.0 4.4 5 0 0 5 5 5 0 ATP synthase protein 8 Peptidase_M20 PF01546.28 EFE41897.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Med10 PF09748.9 EFE41899.1 - 2.6e-38 130.7 0.0 4.4e-38 130.0 0.0 1.4 1 1 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.7 EFE41899.1 - 0.015 15.2 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) Metallophos PF00149.28 EFE41901.1 - 0.0041 17.7 0.2 0.0062 17.1 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFE41901.1 - 0.018 15.3 0.0 0.027 14.7 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Transp_inhibit PF18791.1 EFE41901.1 - 0.097 12.2 0.3 0.2 11.2 0.0 1.8 2 0 0 2 2 2 0 Transport inhibitor response 1 protein domain AAA_16 PF13191.6 EFE41902.1 - 1e-06 29.3 0.3 3.9e-06 27.3 0.3 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EFE41902.1 - 0.00026 21.4 0.0 0.029 14.8 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EFE41902.1 - 0.0049 16.8 0.0 0.0095 15.9 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EFE41902.1 - 0.0085 15.6 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF2859 PF11072.8 EFE41902.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2859) DUF815 PF05673.13 EFE41902.1 - 0.033 13.4 0.0 0.069 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 EFE41902.1 - 0.05 13.9 0.3 0.48 10.7 0.2 2.3 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EFE41902.1 - 0.079 13.0 0.0 0.29 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) CLU PF13236.6 EFE41903.1 - 3.3e-74 249.5 0.0 5.4e-74 248.7 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFE41903.1 - 1.2e-54 185.0 0.0 3.2e-54 183.6 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EFE41903.1 - 5.9e-27 93.8 4.2 1.5e-12 47.6 0.0 3.9 3 1 1 4 4 4 3 Tetratricopeptide repeat CLU_N PF15044.6 EFE41903.1 - 1.6e-24 86.0 0.3 5.5e-24 84.3 0.1 2.1 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 EFE41903.1 - 3.4e-22 77.6 0.6 1.3e-05 24.9 0.0 5.3 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFE41903.1 - 0.00012 22.0 4.9 0.3 11.3 0.1 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFE41903.1 - 0.0041 17.2 4.1 0.14 12.4 0.3 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF727 PF05303.12 EFE41903.1 - 0.0059 16.7 0.0 0.017 15.1 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF727) CDC37_M PF08565.11 EFE41903.1 - 0.11 12.5 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 Cdc37 Hsp90 binding domain TPR_17 PF13431.6 EFE41903.1 - 6.3 7.4 5.9 1.8e+02 2.9 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat NUP50 PF08911.11 EFE41904.1 - 3.1 8.5 5.8 3 8.6 0.5 3.2 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) Ferric_reduct PF01794.19 EFE41905.1 - 1.6e-22 79.9 9.0 1.6e-22 79.9 9.0 2.6 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFE41905.1 - 2.5e-17 63.4 0.0 7.6e-15 55.4 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFE41905.1 - 5.8e-13 48.9 0.0 4.6e-11 42.8 0.0 2.4 1 1 0 1 1 1 1 FAD-binding domain SdpI PF13630.6 EFE41905.1 - 0.81 9.9 7.4 0.099 12.8 1.4 2.7 2 0 0 2 2 2 0 SdpI/YhfL protein family GST_N_3 PF13417.6 EFE41906.1 - 1.7e-15 57.1 0.0 2.9e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFE41906.1 - 1.3e-14 54.3 0.0 2.3e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE41906.1 - 7e-11 42.3 0.0 1.4e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFE41906.1 - 2e-10 40.8 0.0 3.9e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFE41906.1 - 3.8e-10 39.8 0.0 6.7e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE41906.1 - 5.2e-08 32.8 0.0 1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SF1-HH PF16275.5 EFE41907.1 - 1.8e-44 150.7 1.0 2.6e-44 150.1 1.0 1.2 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain Tubulin PF00091.25 EFE41908.1 - 2.6e-54 184.4 0.0 3.2e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 EFE41908.1 - 0.00076 19.2 0.0 0.0014 18.4 0.0 1.4 1 1 0 1 1 1 1 Tubulin domain Lipase_3 PF01764.25 EFE41908.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Pga1 PF10333.9 EFE41909.1 - 0.0017 18.2 0.0 0.0026 17.6 0.0 1.3 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Creatinase_N_2 PF16189.5 EFE41910.1 - 1.8e-51 174.4 0.3 4.4e-51 173.2 0.0 1.8 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EFE41910.1 - 1.9e-29 102.9 0.0 3.1e-29 102.1 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EFE41910.1 - 3.1e-25 88.0 0.3 1e-24 86.3 0.3 2.0 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EFE41910.1 - 2.9e-12 47.4 0.1 3.3e-08 34.2 0.1 3.3 2 1 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Importin_rep_3 PF18806.1 EFE41911.1 - 0.0011 19.0 0.0 0.29 11.2 0.0 2.8 2 0 0 2 2 2 2 Importin 13 repeat Bcl-2 PF00452.19 EFE41911.1 - 0.13 13.0 0.1 37 5.1 0.0 3.6 3 0 0 3 3 3 0 Apoptosis regulator proteins, Bcl-2 family SOR_SNZ PF01680.17 EFE41912.1 - 8.5e-102 339.3 8.1 1.2e-99 332.2 8.1 2.3 1 1 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EFE41912.1 - 1.6e-09 37.5 6.4 1.3e-07 31.2 0.0 2.7 3 1 0 3 3 3 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 EFE41912.1 - 0.0018 17.4 0.0 0.33 10.0 0.0 2.4 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EFE41912.1 - 0.0032 16.9 0.2 0.026 14.0 0.0 2.3 2 1 0 2 2 2 1 Histidine biosynthesis protein TMP-TENI PF02581.17 EFE41912.1 - 0.015 14.7 0.4 0.67 9.3 0.0 3.1 3 0 0 3 3 3 0 Thiamine monophosphate synthase NanE PF04131.14 EFE41912.1 - 0.035 13.3 0.6 0.28 10.4 0.0 2.3 2 1 1 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase TetR_C_27 PF17935.1 EFE41912.1 - 0.038 14.1 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain OMPdecase PF00215.24 EFE41912.1 - 0.053 13.1 0.1 0.42 10.2 0.0 2.1 1 1 2 3 3 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family FUN14 PF04930.15 EFE41913.1 - 9.4e-08 32.4 1.0 2.5e-07 31.0 1.0 1.7 1 1 0 1 1 1 1 FUN14 family TMEM43 PF07787.12 EFE41913.1 - 0.21 10.9 1.0 0.85 9.0 0.7 1.9 2 0 0 2 2 2 0 Transmembrane protein 43 ORC2 PF04084.14 EFE41914.1 - 8.6e-116 386.5 0.0 1.1e-115 386.2 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 AT_hook PF02178.19 EFE41914.1 - 4.1 7.6 9.4 13 6.1 9.4 1.9 1 0 0 1 1 1 0 AT hook motif ArgJ PF01960.18 EFE41915.1 - 6.9e-145 482.5 0.1 7.8e-145 482.3 0.1 1.0 1 0 0 1 1 1 1 ArgJ family SecY PF00344.20 EFE41916.1 - 1.2e-69 234.9 10.0 1.6e-69 234.5 10.0 1.1 1 0 0 1 1 1 1 SecY translocase Spc42p PF11544.8 EFE41918.1 - 0.083 12.9 9.8 0.54 10.3 9.8 2.5 1 0 0 1 1 1 0 Spindle pole body component Spc42p NPV_P10 PF05531.12 EFE41918.1 - 1.7 9.2 10.3 2.4 8.7 2.0 3.7 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Phage_GP20 PF06810.11 EFE41918.1 - 2.4 8.0 28.9 0.75 9.6 19.2 3.6 2 1 0 2 2 2 0 Phage minor structural protein GP20 Sas6_CC PF18594.1 EFE41918.1 - 2.5 7.9 9.7 0.11 12.3 0.5 3.3 3 0 0 3 3 3 0 Sas6/XLF/XRCC4 coiled-coil domain DUF3037 PF11236.8 EFE41918.1 - 8.8 6.8 6.7 15 6.0 3.0 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) DUF1664 PF07889.12 EFE41918.1 - 9.4 6.3 17.8 20 5.2 3.0 3.6 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Promethin PF16015.5 EFE41919.1 - 2e-27 95.2 17.8 2.7e-27 94.8 17.8 1.2 1 0 0 1 1 1 1 Promethin UL45 PF05473.12 EFE41919.1 - 0.048 13.3 2.1 0.082 12.5 2.1 1.5 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like MUG113 PF13455.6 EFE41920.1 - 6.6e-21 74.8 0.7 1.8e-20 73.4 0.7 1.8 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 EFE41920.1 - 2.4e-20 73.0 0.2 6.9e-20 71.5 0.2 1.8 1 0 0 1 1 1 1 T5orf172 domain Glyco_transf_54 PF04666.13 EFE41921.1 - 8.9e-15 54.3 0.0 1.6e-10 40.3 0.0 3.1 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region WD40 PF00400.32 EFE41923.1 - 1e-17 64.2 12.4 0.00041 21.1 0.0 7.8 7 1 1 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE41923.1 - 3e-14 53.1 0.0 0.0059 16.9 0.1 6.7 4 2 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EFE41923.1 - 4.5e-09 36.4 0.8 6.4e-08 32.7 0.1 2.6 2 0 0 2 2 2 1 NACHT domain PD40 PF07676.12 EFE41923.1 - 6e-09 35.6 1.9 7.9 6.6 0.0 7.7 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat AAA_16 PF13191.6 EFE41923.1 - 5.7e-06 26.8 0.0 1.9e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain Lactonase PF10282.9 EFE41923.1 - 8.6e-05 22.0 0.0 0.00025 20.4 0.0 1.8 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller KAP_NTPase PF07693.14 EFE41923.1 - 0.00048 19.5 0.0 0.0008 18.7 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain Peptidase_S8 PF00082.22 EFE41923.1 - 0.00097 18.5 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 Subtilase family Nup160 PF11715.8 EFE41923.1 - 0.0015 17.2 0.0 3.2 6.3 0.0 3.3 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 EFE41923.1 - 0.0031 16.9 0.2 4.3 6.6 0.0 4.1 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 EFE41923.1 - 0.065 12.2 0.1 3.5 6.5 0.0 3.4 4 1 1 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ret2_MD PF18528.1 EFE41923.1 - 0.12 12.8 0.0 1.7e+02 2.6 0.0 4.0 4 0 0 4 4 4 0 RNA editing 3' terminal uridylyl transferase 2 middle domain TsaE PF02367.17 EFE41923.1 - 0.17 11.9 0.1 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Proteasome_A_N PF10584.9 EFE41923.1 - 0.25 11.0 8.9 7.4 6.3 0.0 5.5 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature tRNA-synt_2c PF01411.19 EFE41924.1 - 7.2e-09 34.7 0.0 9.3e-09 34.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EFE41924.1 - 4.6e-06 26.6 0.4 7.6e-06 25.9 0.4 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain NmrA PF05368.13 EFE41925.1 - 0.0011 18.6 0.0 0.0029 17.2 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EFE41925.1 - 0.0015 18.4 0.0 0.15 11.9 0.0 2.8 2 1 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EFE41925.1 - 0.085 12.3 0.0 0.26 10.7 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family FAD_binding_3 PF01494.19 EFE41926.1 - 8.9e-14 51.5 0.1 9.3e-14 51.4 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain MFS_1 PF07690.16 EFE41929.1 - 5e-54 183.6 45.7 5.3e-38 130.9 20.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFE41929.1 - 1.1e-06 27.7 14.0 0.00012 21.0 2.5 2.7 1 1 2 3 3 3 2 MFS_1 like family MFS_3 PF05977.13 EFE41929.1 - 0.0024 16.4 1.9 0.0024 16.4 1.9 2.2 2 1 0 2 2 2 1 Transmembrane secretion effector OATP PF03137.20 EFE41929.1 - 0.0047 15.3 9.4 0.012 14.0 0.0 2.6 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Asp-Al_Ex PF06826.12 EFE41929.1 - 0.086 12.6 17.6 0.024 14.4 7.1 3.0 2 1 1 3 3 3 0 Predicted Permease Membrane Region LacY_symp PF01306.19 EFE41929.1 - 0.1 11.4 5.9 0.45 9.2 0.0 2.5 3 0 0 3 3 3 0 LacY proton/sugar symporter MFS_4 PF06779.14 EFE41929.1 - 0.15 11.3 20.9 0.48 9.6 5.6 3.4 2 2 2 4 4 4 0 Uncharacterised MFS-type transporter YbfB ATG22 PF11700.8 EFE41929.1 - 0.17 10.5 8.5 1.1 7.7 0.5 3.5 4 0 0 4 4 4 0 Vacuole effluxer Atg22 like ABC_membrane PF00664.23 EFE41930.1 - 1.5e-101 339.7 36.4 3.1e-52 177.9 12.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE41930.1 - 1.4e-68 229.7 0.0 5.9e-33 114.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFE41930.1 - 2.2e-15 56.7 0.0 4.9e-05 22.9 0.0 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFE41930.1 - 6.7e-07 29.0 0.9 0.0068 16.1 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFE41930.1 - 1e-06 28.7 0.0 0.0094 15.9 0.0 2.8 3 0 0 3 3 2 2 RsgA GTPase AAA_16 PF13191.6 EFE41930.1 - 2.9e-06 27.8 5.5 0.028 14.8 0.3 3.4 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFE41930.1 - 4.3e-06 27.0 1.4 0.15 12.3 0.1 3.8 2 2 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 EFE41930.1 - 1.2e-05 24.4 2.0 0.059 12.2 0.0 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_21 PF13304.6 EFE41930.1 - 1.8e-05 24.7 1.0 0.68 9.7 0.0 4.0 2 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 EFE41930.1 - 2.5e-05 24.1 2.6 0.2 11.3 0.3 3.7 3 1 0 3 3 3 2 AAA domain AAA_25 PF13481.6 EFE41930.1 - 0.00011 21.9 0.3 0.091 12.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EFE41930.1 - 0.00018 21.3 0.1 0.25 11.0 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 EFE41930.1 - 0.00022 21.7 5.5 0.35 11.3 0.7 4.6 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFE41930.1 - 0.00025 21.0 0.1 0.11 12.4 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_7 PF12775.7 EFE41930.1 - 0.00032 20.2 0.0 0.85 9.1 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 EFE41930.1 - 0.00054 20.0 0.2 0.96 9.4 0.0 3.0 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EFE41930.1 - 0.0021 18.3 0.1 2.6 8.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFE41930.1 - 0.0038 17.8 0.3 1.9 9.1 0.0 2.9 3 0 0 3 3 2 1 AAA domain SRP54 PF00448.22 EFE41930.1 - 0.0046 16.6 0.2 2.3 7.8 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EFE41930.1 - 0.0057 16.0 0.0 4.4 6.5 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin SbcCD_C PF13558.6 EFE41930.1 - 0.0068 16.6 3.1 5.4 7.3 0.4 3.9 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 EFE41930.1 - 0.011 15.5 0.0 5.2 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFE41930.1 - 0.018 15.5 0.0 5.3 7.5 0.0 3.1 2 0 0 2 2 2 0 RNA helicase PRK PF00485.18 EFE41930.1 - 0.047 13.4 0.0 7.3 6.3 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 EFE41930.1 - 0.047 13.9 0.9 8 6.7 0.1 2.9 2 0 0 2 2 2 0 AAA domain SAA PF00277.18 EFE41930.1 - 0.05 14.1 1.1 1.2 9.7 0.0 2.8 3 0 0 3 3 2 0 Serum amyloid A protein APS_kinase PF01583.20 EFE41930.1 - 0.072 13.0 0.1 2.4 8.1 0.0 2.7 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_17 PF13207.6 EFE41930.1 - 0.13 12.7 0.3 46 4.4 0.1 3.3 3 0 0 3 3 3 0 AAA domain G-alpha PF00503.20 EFE41930.1 - 0.15 11.2 0.0 13 4.8 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit AAA_23 PF13476.6 EFE41930.1 - 0.18 12.3 10.7 1.5 9.3 0.0 4.1 4 1 0 4 4 3 0 AAA domain DUF87 PF01935.17 EFE41930.1 - 0.29 11.2 3.3 3.5 7.7 0.1 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain TMIE PF16038.5 EFE41930.1 - 0.58 10.0 2.3 1.5 8.7 0.6 2.6 2 0 0 2 2 2 0 TMIE protein Skp1 PF01466.19 EFE41931.1 - 1e-27 96.0 0.5 1.6e-27 95.3 0.5 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EFE41931.1 - 7.7e-24 83.6 0.1 1.6e-23 82.6 0.1 1.6 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain ORC6 PF05460.13 EFE41931.1 - 2.4 7.3 16.5 0.15 11.3 8.7 2.1 1 1 1 2 2 2 0 Origin recognition complex subunit 6 (ORC6) CDC45 PF02724.14 EFE41932.1 - 2.1 6.5 21.1 2.3 6.4 21.1 1.0 1 0 0 1 1 1 0 CDC45-like protein CAML PF14963.6 EFE41932.1 - 2.1 8.4 9.5 2.6 8.1 9.5 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand eIF-3_zeta PF05091.12 EFE41932.1 - 3.9 6.3 14.8 4 6.3 14.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Dsh_C PF12316.8 EFE41932.1 - 4.4 7.7 9.3 5.4 7.4 9.3 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Presenilin PF01080.17 EFE41932.1 - 5.4 5.7 16.9 6 5.5 16.9 1.1 1 0 0 1 1 1 0 Presenilin Glyco_transf_22 PF03901.17 EFE41933.1 - 2e-35 122.9 14.2 1.8e-33 116.4 14.2 2.2 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family DUF2705 PF10920.8 EFE41933.1 - 0.049 12.9 3.3 0.086 12.2 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2705) Fungal_trans PF04082.18 EFE41934.1 - 3.9e-07 29.4 0.2 3.9e-07 29.4 0.2 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF5327 PF17261.2 EFE41934.1 - 0.49 11.2 6.3 1.5 9.6 6.3 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5327) PAT1 PF09770.9 EFE41934.1 - 6.6 4.9 14.0 9.2 4.4 14.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RINGv PF12906.7 EFE41935.1 - 1.8e-09 37.6 2.2 1.5e-08 34.6 0.6 2.4 2 0 0 2 2 2 1 RING-variant domain GDNF PF02351.16 EFE41935.1 - 0.11 13.5 0.1 0.18 12.8 0.1 1.3 1 0 0 1 1 1 0 GDNF/GAS1 domain PHD_4 PF16866.5 EFE41935.1 - 0.15 12.2 1.9 0.82 9.8 0.6 2.3 2 0 0 2 2 2 0 PHD-finger Herpes_gE PF02480.16 EFE41935.1 - 0.17 10.6 0.1 0.23 10.2 0.1 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF1218 PF06749.12 EFE41935.1 - 0.29 11.7 0.3 0.29 11.7 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) zf-RING_2 PF13639.6 EFE41935.1 - 0.37 11.2 3.6 5.5 7.4 0.8 2.3 2 0 0 2 2 2 0 Ring finger domain PHD PF00628.29 EFE41935.1 - 1.7 8.6 6.2 0.5 10.3 2.8 1.8 2 0 0 2 2 2 0 PHD-finger DUF202 PF02656.15 EFE41935.1 - 7.4 7.1 8.5 80 3.8 8.5 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Proteasome PF00227.26 EFE41936.1 - 7.6e-58 195.1 0.0 5.6e-33 114.0 0.0 2.0 1 1 1 2 2 2 2 Proteasome subunit Ribonuclease_3 PF00636.26 EFE41937.1 - 2.4e-40 137.4 0.0 2.5e-19 69.8 0.0 2.7 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 EFE41937.1 - 3.2e-22 78.5 0.1 8.4e-22 77.1 0.1 1.8 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 EFE41937.1 - 1.9e-19 70.1 0.1 4.4e-11 43.0 0.0 3.7 2 1 0 2 2 2 2 Ribonuclease-III-like DEAD PF00270.29 EFE41937.1 - 2.6e-19 69.7 0.0 5.1e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE41937.1 - 3.3e-15 56.4 0.0 8.8e-15 55.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE41937.1 - 4.7e-14 52.8 0.0 9.4e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit dsrm PF00035.26 EFE41937.1 - 0.0086 16.8 0.1 0.074 13.8 0.0 2.4 2 0 0 2 2 2 1 Double-stranded RNA binding motif zf-C2H2_jaz PF12171.8 EFE41938.1 - 0.0015 18.7 0.9 0.036 14.4 0.0 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 EFE41938.1 - 0.0095 15.8 0.5 1.9 8.5 0.0 2.6 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf-FCS PF06467.14 EFE41938.1 - 0.066 13.2 0.7 0.13 12.2 0.4 1.7 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-H2C2_2 PF13465.6 EFE41938.1 - 0.29 11.6 6.5 0.39 11.2 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE41938.1 - 0.41 11.6 6.2 13 6.9 0.0 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE41938.1 - 0.84 10.2 0.0 0.84 10.2 0.0 3.6 4 1 0 4 4 4 0 Zinc finger, C2H2 type 6PGD PF00393.19 EFE41939.1 - 1.3e-76 257.7 0.0 1.9e-76 257.2 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EFE41939.1 - 2.3e-31 109.1 0.1 4.2e-31 108.3 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EFE41939.1 - 1.4e-06 28.3 0.1 2.6e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EFE41939.1 - 0.00048 20.1 0.0 0.00086 19.3 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 EFE41939.1 - 0.0036 16.9 0.3 0.018 14.6 0.1 2.0 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain F420_oxidored PF03807.17 EFE41939.1 - 0.0038 17.8 0.0 0.012 16.2 0.0 2.0 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EFE41939.1 - 0.0041 17.2 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFE41939.1 - 0.044 13.2 0.9 0.061 12.7 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EFE41939.1 - 0.044 14.0 0.0 0.099 12.9 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EFE41939.1 - 0.057 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RTA1 PF04479.13 EFE41940.1 - 3.2e-71 239.2 5.1 4.3e-71 238.8 5.1 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF3098 PF11297.8 EFE41940.1 - 0.079 12.6 3.4 1.5 8.5 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3098) LSM PF01423.22 EFE41942.1 - 1.1e-14 53.9 0.1 1.8e-14 53.2 0.1 1.4 1 0 0 1 1 1 1 LSM domain DUF334 PF03904.13 EFE41942.1 - 0.14 11.7 0.1 0.34 10.4 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF334) NUC173 PF08161.12 EFE41943.1 - 3.2e-78 262.1 0.7 1.1e-75 253.7 0.1 3.1 3 0 0 3 3 3 2 NUC173 domain HEAT_2 PF13646.6 EFE41943.1 - 0.021 15.2 0.6 1 9.8 0.5 3.7 2 1 1 3 3 3 0 HEAT repeats RsbRD_N PF14361.6 EFE41943.1 - 0.12 13.1 1.9 1.3 9.8 0.0 3.8 5 0 0 5 5 5 0 RsbT co-antagonist protein rsbRD N-terminal domain Zip PF02535.22 EFE41944.1 - 8.1e-05 22.0 3.4 0.016 14.4 1.5 2.3 2 0 0 2 2 2 2 ZIP Zinc transporter DDHD PF02862.17 EFE41944.1 - 0.0027 17.9 1.6 0.14 12.3 0.9 2.2 2 0 0 2 2 2 1 DDHD domain CENP-B_dimeris PF09026.10 EFE41944.1 - 0.02 15.3 5.6 0.02 15.3 5.6 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PPP4R2 PF09184.11 EFE41944.1 - 0.54 9.8 24.1 0.038 13.6 15.4 2.0 2 0 0 2 2 2 0 PPP4R2 RPN2_C PF18004.1 EFE41944.1 - 0.72 9.8 7.1 1.6 8.6 7.1 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Connexin PF00029.19 EFE41944.1 - 1.2 8.8 3.7 0.94 9.2 0.4 2.0 2 0 0 2 2 2 0 Connexin Presenilin PF01080.17 EFE41944.1 - 2.4 6.8 13.4 0.3 9.8 4.7 2.1 2 0 0 2 2 2 0 Presenilin Adeno_E3B PF03376.14 EFE41944.1 - 3.1 8.1 4.8 1.1 9.5 1.3 2.0 2 0 0 2 2 2 0 Adenovirus E3B protein XRN_N PF03159.18 EFE41944.1 - 3.9 6.8 6.2 0.6 9.5 1.9 1.8 3 0 0 3 3 3 0 XRN 5'-3' exonuclease N-terminus GEMIN8 PF15348.6 EFE41944.1 - 5.5 7.2 27.5 3.9 7.7 15.7 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 Smg8_Smg9 PF10220.9 EFE41944.1 - 7 4.8 11.0 2.6 6.3 6.4 1.9 2 0 0 2 2 2 0 Smg8_Smg9 DUF4746 PF15928.5 EFE41944.1 - 7.5 5.9 13.7 14 5.0 13.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) AF-4 PF05110.13 EFE41944.1 - 9.3 4.2 27.6 2.2 6.2 8.8 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein RRM_1 PF00076.22 EFE41945.1 - 3.2e-09 36.5 0.0 7.1e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RF-1 PF00472.20 EFE41946.1 - 0.0081 16.1 5.1 0.053 13.5 5.1 1.9 1 1 0 1 1 1 1 RF-1 domain U3_assoc_6 PF08640.11 EFE41947.1 - 1.5e-28 98.7 1.0 1.5e-28 98.7 1.0 2.1 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 EFE41947.1 - 0.0022 18.7 4.9 0.11 13.4 0.4 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF4464 PF14713.6 EFE41947.1 - 0.0058 16.2 0.1 0.0085 15.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4464) NRDE-2 PF08424.10 EFE41947.1 - 0.056 12.6 0.3 0.11 11.6 0.1 1.4 1 1 0 1 1 1 0 NRDE-2, necessary for RNA interference Frag1 PF10277.9 EFE41948.1 - 1.1e-39 136.2 6.8 1.1e-39 136.2 6.8 2.5 2 1 0 2 2 2 1 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 EFE41948.1 - 0.02 14.4 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Apolipoprotein PF01442.18 EFE41949.1 - 0.00027 20.9 0.2 0.00035 20.5 0.2 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Syntaxin PF00804.25 EFE41949.1 - 0.072 12.8 0.4 0.087 12.5 0.4 1.2 1 0 0 1 1 1 0 Syntaxin DUF883 PF05957.13 EFE41949.1 - 0.8 10.3 4.4 0.87 10.2 1.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) CDT1_C PF16679.5 EFE41950.1 - 2.7e-19 69.4 0.7 6.2e-19 68.2 0.7 1.7 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain Lactamase_B_6 PF16661.5 EFE41951.1 - 2.5e-65 219.6 0.0 5.5e-65 218.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EFE41951.1 - 1.7e-45 155.3 3.1 1.9e-45 155.1 0.1 2.4 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 EFE41951.1 - 2.3e-17 63.3 0.0 8.2e-17 61.5 0.0 2.0 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EFE41951.1 - 7.4e-13 48.2 0.0 1.7e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EFE41951.1 - 0.08 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily tRNA-synt_2 PF00152.20 EFE41953.1 - 4.7e-67 226.3 0.0 3.4e-66 223.5 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFE41953.1 - 5e-07 29.6 0.0 1.3e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Gti1_Pac2 PF09729.9 EFE41954.1 - 3.6e-44 151.0 6.0 3e-38 131.7 0.1 2.5 2 1 1 3 3 3 2 Gti1/Pac2 family DUF2434 PF10361.9 EFE41955.1 - 1.4e-121 405.0 6.4 1.8e-121 404.7 6.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) DKCLD PF08068.12 EFE41955.1 - 0.18 11.9 0.4 0.5 10.5 0.0 1.9 2 0 0 2 2 2 0 DKCLD (NUC011) domain Flg_new PF09479.10 EFE41957.1 - 0.045 13.9 0.0 0.056 13.6 0.0 1.1 1 0 0 1 1 1 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) bZIP_C PF12498.8 EFE41958.1 - 0.67 10.9 10.6 0.27 12.2 1.1 2.4 1 1 2 3 3 3 0 Basic leucine-zipper C terminal Annexin PF00191.20 EFE41959.1 - 2.9e-62 206.7 0.1 2e-17 63.0 0.0 4.2 4 0 0 4 4 4 4 Annexin DUF5617 PF18493.1 EFE41959.1 - 6.3e-05 23.0 2.9 0.089 12.9 0.8 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF5617) EBP PF05241.12 EFE41960.1 - 5.9e-63 211.5 3.4 7.1e-63 211.3 3.4 1.1 1 0 0 1 1 1 1 Emopamil binding protein NOA36 PF06524.12 EFE41961.1 - 4.4 6.5 12.2 8.5 5.6 0.9 2.3 2 0 0 2 2 2 0 NOA36 protein zf-RING_UBOX PF13445.6 EFE41962.1 - 4.4e-08 33.0 5.8 4.4e-08 33.0 5.8 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFE41962.1 - 6.4e-08 32.3 5.3 6.4e-08 32.3 5.3 4.6 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFE41962.1 - 3.4e-07 30.0 2.5 3.4e-07 30.0 2.5 4.2 5 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFE41962.1 - 8.2e-06 26.1 6.9 8.2e-06 26.1 6.9 4.4 4 0 0 4 4 4 1 Ring finger domain zf-RING_6 PF14835.6 EFE41962.1 - 1.7e-05 24.6 0.7 1.7e-05 24.6 0.7 2.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EFE41962.1 - 0.00024 21.2 7.0 0.00024 21.2 7.0 3.7 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING SH3_9 PF14604.6 EFE41962.1 - 0.0015 18.4 0.1 0.0015 18.4 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EFE41962.1 - 0.15 11.7 0.2 0.38 10.4 0.2 1.7 1 0 0 1 1 1 0 SH3 domain FHA PF00498.26 EFE41964.1 - 2.2e-16 59.9 0.0 4.4e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFE41964.1 - 0.00021 21.6 0.0 0.00057 20.1 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain CENP-Q PF13094.6 EFE41964.1 - 0.046 13.9 14.9 0.24 11.6 2.0 2.8 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Jnk-SapK_ap_N PF09744.9 EFE41964.1 - 0.048 13.9 13.6 0.38 11.0 3.9 2.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 MscS_porin PF12795.7 EFE41964.1 - 1.2 8.6 26.3 0.17 11.4 5.8 3.1 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain Fungal_trans_2 PF11951.8 EFE41965.1 - 2.1e-69 234.2 0.1 2.7e-69 233.8 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE41965.1 - 1.5e-09 37.8 10.0 2.7e-09 37.0 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 EFE41965.1 - 2 8.6 10.0 7.1 6.9 10.0 2.0 1 0 0 1 1 1 0 AT hook motif ABC_tran PF00005.27 EFE41966.1 - 6.2e-50 169.3 0.1 4.4e-25 88.8 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 EFE41966.1 - 3.3e-48 163.9 34.0 1.8e-25 89.6 13.9 2.3 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.6 EFE41966.1 - 1.6e-11 44.5 6.5 0.0025 17.7 0.1 4.4 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFE41966.1 - 1e-08 36.0 1.3 0.00023 21.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 EFE41966.1 - 2.2e-08 33.8 0.4 0.014 14.8 0.1 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFE41966.1 - 3.4e-07 30.8 0.1 0.021 15.2 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFE41966.1 - 4.9e-07 29.8 3.7 0.015 15.2 0.9 2.5 2 1 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EFE41966.1 - 3e-06 26.9 2.2 0.087 12.6 0.0 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.12 EFE41966.1 - 5.5e-05 23.2 1.1 0.051 13.5 0.1 2.4 2 0 0 2 2 2 2 NACHT domain AAA_30 PF13604.6 EFE41966.1 - 0.00013 21.7 0.3 0.16 11.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFE41966.1 - 0.00017 21.9 0.4 0.5 10.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EFE41966.1 - 0.00018 21.8 0.2 0.21 11.8 0.1 2.4 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 EFE41966.1 - 0.00019 21.4 0.3 0.0043 17.0 0.0 2.2 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_15 PF13175.6 EFE41966.1 - 0.00021 21.1 0.2 3.4 7.3 0.2 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 EFE41966.1 - 0.0003 21.2 0.4 1.6 9.2 0.1 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFE41966.1 - 0.0021 18.4 0.2 1.2 9.5 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 EFE41966.1 - 0.0025 17.4 0.2 0.31 10.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EFE41966.1 - 0.0038 16.8 2.6 0.32 10.6 0.2 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.6 EFE41966.1 - 0.008 16.5 0.6 1.3 9.4 0.1 2.4 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFE41966.1 - 0.01 14.9 0.1 1.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein DnaB_C PF03796.15 EFE41966.1 - 0.012 15.0 0.2 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_5 PF07728.14 EFE41966.1 - 0.012 15.6 0.4 5.6 7.0 0.0 3.7 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFE41966.1 - 0.02 14.6 0.3 2.9 7.6 0.1 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain MMR_HSR1 PF01926.23 EFE41966.1 - 0.021 14.9 2.4 0.36 10.9 0.5 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase Roc PF08477.13 EFE41966.1 - 0.023 14.9 0.9 3.4 7.9 0.2 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 EFE41966.1 - 0.037 14.0 0.4 8 6.3 0.2 2.7 3 0 0 3 3 3 0 NTPase AAA_18 PF13238.6 EFE41966.1 - 0.038 14.5 0.1 3.3 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 EFE41966.1 - 0.078 12.7 0.6 4.6 6.9 0.2 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.6 EFE41966.1 - 0.12 12.8 1.2 5.3 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFE41966.1 - 0.13 11.9 1.2 8 6.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 EFE41966.1 - 0.14 11.6 2.0 6.7 6.1 0.4 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein DUF2075 PF09848.9 EFE41966.1 - 0.18 11.0 0.2 12 5.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EFE41966.1 - 0.2 11.4 0.5 2 8.1 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein MobB PF03205.14 EFE41966.1 - 0.21 11.5 1.0 14 5.6 0.2 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.12 EFE41966.1 - 0.22 10.8 0.7 9.2 5.5 0.2 2.4 2 0 0 2 2 2 0 Zeta toxin Bys1 PF04681.12 EFE41967.1 - 1.5e-05 24.9 0.2 1.9e-05 24.6 0.2 1.2 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Thaumatin PF00314.17 EFE41967.1 - 0.01 15.5 0.6 0.025 14.2 0.5 1.6 1 1 0 1 1 1 0 Thaumatin family Sec23_trunk PF04811.15 EFE41968.1 - 1.2e-48 165.8 0.0 8.2e-48 163.1 0.0 2.0 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EFE41968.1 - 2e-17 63.7 0.0 5.2e-17 62.4 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EFE41968.1 - 6.4e-16 58.0 0.1 2.9e-15 56.0 0.0 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EFE41968.1 - 9.4e-16 57.6 5.5 2e-15 56.5 5.5 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EFE41968.1 - 3.2e-06 26.9 0.0 6.8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat AA_permease_2 PF13520.6 EFE41969.1 - 1e-32 113.5 16.9 1.1e-32 113.4 16.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE41969.1 - 1.1e-10 40.8 13.6 1.2e-10 40.6 13.6 1.0 1 0 0 1 1 1 1 Amino acid permease DPM3 PF08285.11 EFE41969.1 - 1.7 8.9 6.4 3.6 7.9 1.9 2.4 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) RRM_1 PF00076.22 EFE41970.1 - 2.9e-14 52.6 0.0 5.4e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Chlorosome_CsmC PF11098.8 EFE41970.1 - 0.098 12.6 0.2 0.098 12.6 0.2 1.6 2 0 0 2 2 2 0 Chlorosome envelope protein C MOZ_SAS PF01853.18 EFE41971.1 - 1.9e-64 216.6 0.0 2.7e-64 216.1 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EFE41971.1 - 6.2e-15 54.5 0.2 1.1e-14 53.7 0.2 1.4 1 0 0 1 1 1 1 MYST family zinc finger domain Cpn60_TCP1 PF00118.24 EFE41972.1 - 3.4e-140 467.9 0.3 3.8e-140 467.8 0.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nop PF01798.18 EFE41973.1 - 9.5e-87 290.3 0.0 9.5e-87 290.3 0.0 1.8 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFE41973.1 - 1.3e-10 41.5 0.1 1.3e-10 41.5 0.1 3.4 4 0 0 4 4 4 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.11 EFE41973.1 - 0.24 11.5 34.9 0.41 10.7 34.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 YL1 PF05764.13 EFE41973.1 - 0.53 10.4 27.3 0.94 9.5 27.3 1.4 1 0 0 1 1 1 0 YL1 nuclear protein RP-C_C PF11800.8 EFE41973.1 - 0.59 10.2 10.0 3.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region GAGA_bind PF06217.12 EFE41973.1 - 3 8.0 13.9 5.8 7.1 13.9 1.5 1 0 0 1 1 1 0 GAGA binding protein-like family GvpL_GvpF PF06386.11 EFE41974.1 - 0.013 15.4 0.1 0.019 14.9 0.1 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF3767 PF12597.8 EFE41975.1 - 9.9e-33 112.0 0.2 2e-32 111.0 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3767) DUF1744 PF08490.12 EFE41976.1 - 1.4e-149 498.1 0.3 2e-149 497.5 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EFE41976.1 - 7.8e-82 275.1 0.2 2.4e-81 273.5 0.2 1.9 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EFE41976.1 - 1.9e-16 59.9 0.4 1.6e-12 46.9 0.0 4.5 4 1 0 4 4 4 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EFE41976.1 - 1e-09 38.4 0.1 3.3e-09 36.7 0.1 1.9 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EFE41976.1 - 2.2e-05 24.5 0.0 9.5e-05 22.5 0.0 2.2 1 0 0 1 1 1 1 RNase_H superfamily Pkinase PF00069.25 EFE41977.1 - 4.8e-63 213.0 0.0 5.5e-62 209.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE41977.1 - 1.6e-23 83.4 0.0 4.3e-23 81.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE41977.1 - 8.8e-08 31.8 0.0 1.4e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFE41977.1 - 0.00014 20.8 0.0 0.00022 20.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFE41977.1 - 0.00059 19.8 0.1 0.00089 19.2 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFE41977.1 - 0.00066 19.1 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AMMECR1 PF01871.17 EFE41978.1 - 6.5e-34 116.9 0.0 2.3e-33 115.2 0.0 1.8 1 1 0 1 1 1 1 AMMECR1 DUF4880 PF16220.5 EFE41978.1 - 0.039 13.8 0.4 0.086 12.7 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4880) SGT1 PF07093.11 EFE41979.1 - 8.3e-93 311.8 9.8 3.2e-82 276.8 0.0 2.1 1 1 1 2 2 2 2 SGT1 protein Cnn_1N PF07989.11 EFE41980.1 - 1.7e-19 69.7 1.4 1.7e-19 69.7 1.4 14.7 8 2 5 13 13 13 3 Centrosomin N-terminal motif 1 PACT_coil_coil PF10495.9 EFE41980.1 - 1.2e-11 45.0 2.5 1.2e-11 45.0 2.5 5.9 5 1 0 5 5 5 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein TMF_DNA_bd PF12329.8 EFE41980.1 - 3.5e-07 30.1 14.0 3.5e-07 30.1 14.0 15.2 9 5 7 16 16 16 4 TATA element modulatory factor 1 DNA binding Pox_A_type_inc PF04508.12 EFE41980.1 - 0.016 15.0 1.9 0.016 15.0 1.9 10.1 9 2 2 11 11 11 0 Viral A-type inclusion protein repeat AAA PF00004.29 EFE41981.1 - 6.6e-43 146.3 0.0 1.1e-42 145.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFE41981.1 - 2.3e-27 94.8 0.1 7.3e-27 93.1 0.1 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EFE41981.1 - 9.3e-24 83.3 1.8 2e-23 82.2 1.8 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EFE41981.1 - 1.1e-05 25.2 0.0 3e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EFE41981.1 - 1.2e-05 25.1 0.0 2.7e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFE41981.1 - 2.3e-05 24.8 0.0 0.00013 22.4 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 EFE41981.1 - 3.9e-05 23.8 0.0 0.00046 20.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EFE41981.1 - 9.8e-05 22.2 0.0 0.0002 21.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 EFE41981.1 - 0.0001 22.3 0.0 0.00047 20.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EFE41981.1 - 0.00018 21.6 0.0 0.00047 20.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 EFE41981.1 - 0.00018 22.1 0.0 0.003 18.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EFE41981.1 - 0.00018 20.8 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EFE41981.1 - 0.00028 21.1 0.1 0.022 15.0 0.0 2.5 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EFE41981.1 - 0.00083 18.6 0.0 0.0065 15.7 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 EFE41981.1 - 0.0014 18.8 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EFE41981.1 - 0.0036 17.7 0.0 0.012 16.0 0.0 1.9 2 0 0 2 2 1 1 RNA helicase AAA_24 PF13479.6 EFE41981.1 - 0.0038 17.0 0.0 0.012 15.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFE41981.1 - 0.0081 16.6 0.0 0.051 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFE41981.1 - 0.017 14.7 0.1 0.72 9.4 0.1 2.7 2 1 1 3 3 3 0 AAA domain AAA_7 PF12775.7 EFE41981.1 - 0.019 14.5 0.0 0.098 12.2 0.0 2.1 2 1 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 EFE41981.1 - 0.025 13.9 0.0 8.9 5.6 0.0 2.9 2 1 0 3 3 3 0 KaiC NACHT PF05729.12 EFE41981.1 - 0.036 14.0 0.0 0.37 10.7 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Mg_chelatase PF01078.21 EFE41981.1 - 0.04 13.3 0.0 0.081 12.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI USP8_dimer PF08969.11 EFE41981.1 - 0.069 13.3 0.7 0.13 12.4 0.7 1.5 1 0 0 1 1 1 0 USP8 dimerisation domain Parvo_NS1 PF01057.17 EFE41981.1 - 0.079 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 EFE41981.1 - 0.082 12.3 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase_2 PF01637.18 EFE41981.1 - 0.086 12.7 0.0 0.73 9.7 0.0 2.2 1 1 0 2 2 2 0 ATPase domain predominantly from Archaea Torsin PF06309.11 EFE41981.1 - 0.098 12.8 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Torsin Sigma54_activat PF00158.26 EFE41981.1 - 0.14 11.9 0.0 0.5 10.1 0.0 1.9 1 1 1 2 2 2 0 Sigma-54 interaction domain ParB PF08775.10 EFE41981.1 - 0.15 12.6 0.0 0.35 11.4 0.0 1.6 1 0 0 1 1 1 0 ParB family TPR_1 PF00515.28 EFE41981.1 - 0.15 12.0 0.6 0.6 10.0 0.6 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Prefoldin_2 PF01920.20 EFE41982.1 - 4.2e-18 65.3 17.8 4.6e-17 61.9 16.4 2.1 1 1 0 1 1 1 1 Prefoldin subunit Spc24 PF08286.11 EFE41982.1 - 6.6e-05 23.1 6.9 0.0034 17.6 3.5 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Prefoldin_3 PF13758.6 EFE41982.1 - 0.01 15.8 5.7 0.022 14.8 4.9 1.8 1 1 1 2 2 2 0 Prefoldin subunit HDV_ag PF01517.18 EFE41982.1 - 0.038 13.8 0.2 0.046 13.5 0.2 1.3 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen Taxilin PF09728.9 EFE41982.1 - 0.042 13.0 12.2 0.022 14.0 5.9 2.1 2 0 0 2 2 2 0 Myosin-like coiled-coil protein Prefoldin PF02996.17 EFE41982.1 - 0.055 13.4 11.3 0.18 11.7 0.2 2.6 2 1 0 2 2 2 0 Prefoldin subunit Swi5 PF07061.11 EFE41982.1 - 0.062 13.4 9.8 1.8 8.7 5.3 2.3 2 0 0 2 2 2 0 Swi5 CMAS PF02353.20 EFE41982.1 - 0.079 12.2 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF4895 PF16236.5 EFE41982.1 - 0.094 12.5 1.1 0.12 12.2 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4895) TolA_bind_tri PF16331.5 EFE41982.1 - 0.17 12.0 15.4 0.91 9.7 6.3 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation GAS PF13851.6 EFE41982.1 - 0.2 11.0 12.5 0.079 12.3 5.6 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4164 PF13747.6 EFE41982.1 - 0.24 11.7 6.8 0.51 10.6 4.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) betaPIX_CC PF16523.5 EFE41982.1 - 0.31 10.9 6.1 0.1 12.4 2.5 2.0 2 0 0 2 2 2 0 betaPIX coiled coil UPF0242 PF06785.11 EFE41982.1 - 0.34 11.0 13.6 0.16 12.1 5.8 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus MnmE_helical PF12631.7 EFE41982.1 - 0.41 10.8 4.8 0.33 11.1 0.3 2.0 2 0 0 2 2 2 0 MnmE helical domain Tropomyosin_1 PF12718.7 EFE41982.1 - 0.63 10.2 14.5 0.47 10.6 7.3 2.2 2 0 0 2 2 2 0 Tropomyosin like T2SSM PF04612.12 EFE41982.1 - 0.93 9.5 6.0 0.34 11.0 2.4 1.9 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M TPR_MLP1_2 PF07926.12 EFE41982.1 - 0.98 9.5 16.6 0.22 11.6 8.3 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DivIC PF04977.15 EFE41982.1 - 1 9.2 21.0 0.69 9.7 3.6 3.1 2 1 1 3 3 3 0 Septum formation initiator DUF1664 PF07889.12 EFE41982.1 - 1.2 9.2 10.5 2.7 8.1 4.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ABC_tran_CTD PF16326.5 EFE41982.1 - 1.3 9.4 18.6 0.32 11.3 6.2 3.5 2 2 1 3 3 3 0 ABC transporter C-terminal domain DUF4200 PF13863.6 EFE41982.1 - 1.3 9.4 14.7 5.8 7.3 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) OmpH PF03938.14 EFE41982.1 - 1.6 9.1 23.8 3.1e+02 1.6 24.0 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) CENP-Q PF13094.6 EFE41982.1 - 1.7 8.8 12.7 2.5 8.3 12.7 1.3 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit NPV_P10 PF05531.12 EFE41982.1 - 2.2 8.8 9.2 1.8 9.1 3.5 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein YjcZ PF13990.6 EFE41982.1 - 2.3 7.5 6.4 5.2 6.4 2.9 2.0 2 0 0 2 2 2 0 YjcZ-like protein Uso1_p115_C PF04871.13 EFE41982.1 - 2.5 8.5 15.8 0.21 12.0 8.1 2.1 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4407 PF14362.6 EFE41982.1 - 2.6 7.3 11.6 5.1 6.4 11.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Rx_N PF18052.1 EFE41982.1 - 3 8.2 9.6 0.5 10.7 3.6 2.4 2 1 0 2 2 2 0 Rx N-terminal domain MtrG PF04210.13 EFE41982.1 - 3.2 7.7 5.6 3.6 7.5 0.5 2.8 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Flagellin_N PF00669.20 EFE41982.1 - 3.6 7.7 7.7 0.81 9.8 4.1 1.7 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region Fib_alpha PF08702.10 EFE41982.1 - 5.6 7.1 12.6 2.3 8.4 2.0 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family iPGM_N PF06415.13 EFE41983.1 - 1.7e-77 259.8 0.0 2.2e-77 259.3 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 EFE41983.1 - 9.4e-71 238.1 0.0 1.1e-70 237.9 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EFE41983.1 - 0.00028 20.4 0.0 0.012 15.0 0.0 2.5 2 1 1 3 3 3 1 Sulfatase Alk_phosphatase PF00245.20 EFE41983.1 - 0.019 13.9 0.1 0.079 11.9 0.0 1.8 2 0 0 2 2 2 0 Alkaline phosphatase Med9 PF07544.13 EFE41984.1 - 8.4e-15 54.6 0.1 1.6e-14 53.7 0.1 1.7 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.8 EFE41984.1 - 0.33 11.2 3.8 2.6 8.3 0.1 2.1 2 0 0 2 2 2 0 Subunit 21 of Mediator complex SHMT PF00464.19 EFE41985.1 - 1.9e-202 672.2 0.0 2.4e-202 671.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EFE41985.1 - 3.8e-06 26.3 0.0 1.3e-05 24.6 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFE41985.1 - 0.00069 18.7 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EFE41985.1 - 0.14 10.7 0.0 0.26 9.8 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme RNA_polI_A34 PF08208.11 EFE41986.1 - 9.3e-43 146.7 10.4 9.3e-43 146.7 10.4 3.4 2 1 1 3 3 3 1 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.14 EFE41986.1 - 0.21 9.9 31.3 0.018 13.4 3.6 2.1 2 0 0 2 2 2 0 CDC45-like protein Nop14 PF04147.12 EFE41986.1 - 3.7 5.7 37.2 0.13 10.5 10.5 2.1 2 0 0 2 2 2 0 Nop14-like family BSP_II PF05432.11 EFE41986.1 - 4.1 7.0 34.0 0.088 12.5 11.8 2.4 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) SpoIIIAH PF12685.7 EFE41986.1 - 5 6.9 26.5 0.047 13.5 5.6 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein GAGA_bind PF06217.12 EFE41986.1 - 7.8 6.7 21.4 1.2 9.3 11.4 2.4 2 0 0 2 2 2 0 GAGA binding protein-like family CLP1_P PF16575.5 EFE41987.1 - 1.3e-28 100.0 0.0 1e-27 97.2 0.0 2.3 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF3095 PF11294.8 EFE41987.1 - 0.027 13.6 0.0 0.044 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) AAA_33 PF13671.6 EFE41987.1 - 0.17 12.0 0.7 2 8.5 0.0 2.8 3 1 0 3 3 3 0 AAA domain DUF4640 PF15480.6 EFE41990.1 - 0.00046 20.0 4.2 0.00056 19.8 4.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4640) BSMAP PF12280.8 EFE41990.1 - 0.0017 18.6 2.5 0.0025 18.1 2.5 1.5 1 1 0 1 1 1 1 Brain specific membrane anchored protein RR_TM4-6 PF06459.12 EFE41990.1 - 0.052 13.4 5.3 0.062 13.1 5.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LAP1C PF05609.12 EFE41990.1 - 0.1 11.7 7.6 0.12 11.4 7.6 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) EOS1 PF12326.8 EFE41990.1 - 0.1 12.5 0.3 0.12 12.3 0.3 1.2 1 0 0 1 1 1 0 N-glycosylation protein CCDC71L PF15374.6 EFE41990.1 - 2.1 7.5 14.7 2.7 7.2 14.7 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Folliculin PF11704.8 EFE41991.1 - 4.7e-50 170.1 0.2 1.6e-49 168.3 0.0 1.9 2 0 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport CSN8_PSD8_EIF3K PF10075.9 EFE41992.1 - 9e-46 155.4 0.0 1.2e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PDCD2_C PF04194.13 EFE41993.1 - 3.7e-43 147.6 1.4 1e-42 146.2 0.0 2.3 2 1 1 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain CENP-B_dimeris PF09026.10 EFE41994.1 - 0.76 10.2 6.1 1.8 9.0 6.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EFE41994.1 - 0.88 9.2 3.3 1.8 8.2 3.3 1.5 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 EFE41994.1 - 8 4.4 9.3 12 3.9 9.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Prenylcys_lyase PF07156.14 EFE41996.1 - 7.8e-96 321.3 0.0 1e-95 320.9 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 EFE41996.1 - 8.4e-15 55.0 0.0 1.3e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFE41996.1 - 6.1e-11 42.4 0.0 1.6e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFE41996.1 - 1e-06 28.6 0.0 0.017 14.7 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Glyco_transf_28 PF03033.20 EFE41997.1 - 1.1e-29 103.2 0.0 5.4e-29 101.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EFE41997.1 - 0.0052 15.6 0.0 0.0084 15.0 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Vma12 PF11712.8 EFE41998.1 - 2e-40 138.1 0.0 3e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase HPP PF04982.13 EFE41998.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 HPP family Amidohydro_1 PF01979.20 EFE41999.1 - 8e-25 87.9 0.0 1.9e-24 86.7 0.0 1.6 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFE41999.1 - 3.7e-11 43.2 0.0 8.2e-06 25.5 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Arylsulfotran_N PF17425.2 EFE41999.1 - 0.036 14.1 0.0 0.072 13.1 0.0 1.4 1 0 0 1 1 1 0 Arylsulfotransferase Ig-like domain Glyco_hydro_26 PF02156.15 EFE41999.1 - 0.18 11.2 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 Glyco_transf_24 PF18404.1 EFE42000.1 - 3.6e-149 495.5 0.9 5.6e-149 494.9 0.9 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EFE42000.1 - 2.1e-65 221.2 0.6 7.3e-64 216.2 0.1 2.9 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EFE42000.1 - 8.6e-48 162.7 0.4 8.6e-48 162.7 0.4 1.9 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 EFE42000.1 - 1e-43 149.7 0.6 1.4e-42 146.1 0.0 2.9 4 0 0 4 4 4 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EFE42000.1 - 1.3e-42 144.9 1.9 1.9e-42 144.4 0.5 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EFE42000.1 - 5.7e-41 139.0 0.0 1.1e-40 138.1 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.20 EFE42000.1 - 0.0009 18.9 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 DUF1416 PF07210.12 EFE42000.1 - 0.21 11.5 0.0 0.71 9.8 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1416) PhzC-PhzF PF02567.16 EFE42003.1 - 0.00043 19.8 0.3 0.01 15.3 0.1 2.1 2 0 0 2 2 2 2 Phenazine biosynthesis-like protein KH_6 PF15985.5 EFE42004.1 - 7.1e-16 58.3 0.1 1.3e-15 57.5 0.1 1.5 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EFE42004.1 - 0.023 14.6 0.5 0.14 12.1 0.2 2.4 2 0 0 2 2 2 0 Exosome complex exonuclease Rrp40 N-terminal domain Rpp20 PF12328.8 EFE42006.1 - 6.1e-45 152.6 10.2 1e-44 151.8 10.2 1.4 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EFE42006.1 - 2.5e-14 52.8 0.4 5.1e-14 51.8 0.4 1.6 1 0 0 1 1 1 1 Alba SRP14 PF02290.15 EFE42006.1 - 0.29 11.5 3.8 0.42 11.0 2.8 1.8 1 1 0 1 1 1 0 Signal recognition particle 14kD protein SBP_bac_1 PF01547.25 EFE42008.1 - 0.0032 17.5 0.1 2.4 8.0 0.0 2.1 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein EamA PF00892.20 EFE42008.1 - 0.041 14.0 20.1 0.09 12.9 5.2 2.6 2 1 1 3 3 3 0 EamA-like transporter family HSP70 PF00012.20 EFE42009.1 - 1.3e-82 278.0 3.2 4e-82 276.3 0.6 2.0 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EFE42009.1 - 9.9e-12 44.3 0.7 1.5e-11 43.7 0.7 1.3 1 0 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.8 EFE42009.1 - 0.0048 16.0 0.1 2.2 7.2 0.0 2.7 2 1 1 3 3 3 2 Type IV pilus assembly protein PilM; PI3K_1B_p101 PF10486.9 EFE42009.1 - 0.042 11.6 0.5 0.062 11.1 0.5 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit FAM176 PF14851.6 EFE42009.1 - 0.08 12.6 1.2 0.18 11.4 1.2 1.6 1 0 0 1 1 1 0 FAM176 family Cwf_Cwc_15 PF04889.12 EFE42009.1 - 0.15 11.7 5.5 0.29 10.8 5.5 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 EFE42009.1 - 0.18 12.2 6.7 0.38 11.2 6.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 EFE42009.1 - 0.67 10.0 4.2 0.4 10.7 1.1 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal Radial_spoke PF04712.12 EFE42009.1 - 1.4 7.8 5.6 2.3 7.1 5.6 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein DNA_pol_phi PF04931.13 EFE42009.1 - 3.7 5.5 7.7 5.5 5.0 7.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EFE42009.1 - 4.5 6.5 7.2 7.1 5.8 7.2 1.2 1 0 0 1 1 1 0 NOA36 protein Rogdi_lz PF10259.9 EFE42010.1 - 8.7e-85 284.4 0.0 9.9e-85 284.2 0.0 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein BNR_2 PF13088.6 EFE42011.1 - 3e-12 46.4 0.0 7.7e-12 45.1 0.0 1.6 1 1 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.6 EFE42011.1 - 1.9e-10 40.5 0.0 2.6e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Rsm22 PF09243.10 EFE42012.1 - 3.8e-29 101.8 0.0 2.3e-28 99.2 0.0 2.1 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 INTS2 PF14750.6 EFE42012.1 - 0.035 11.7 0.0 0.048 11.2 0.0 1.1 1 0 0 1 1 1 0 Integrator complex subunit 2 Methyltransf_23 PF13489.6 EFE42012.1 - 0.077 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DASH_Spc19 PF08287.11 EFE42013.1 - 1.3e-49 168.1 3.7 1.8e-49 167.6 3.7 1.2 1 0 0 1 1 1 1 Spc19 LPD30 PF18850.1 EFE42013.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent protein associated domain 30 LRR_8 PF13855.6 EFE42015.1 - 7.6e-09 35.2 0.9 1.6e-08 34.2 0.9 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 EFE42015.1 - 1.3e-05 25.4 0.8 3.5e-05 24.1 0.3 2.0 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) MGC-24 PF05283.11 EFE42016.1 - 0.16 12.4 2.5 0.22 12.0 2.5 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin LysM PF01476.20 EFE42017.1 - 3.8e-08 33.2 0.0 0.0011 19.0 0.0 2.2 2 0 0 2 2 2 2 LysM domain DUF3425 PF11905.8 EFE42018.1 - 3.9e-23 81.8 1.4 6.7e-23 81.0 1.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) G_path_suppress PF15991.5 EFE42018.1 - 0.064 13.4 7.1 0.11 12.7 7.1 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor bZIP_1 PF00170.21 EFE42018.1 - 0.13 12.4 11.8 0.075 13.1 8.6 2.1 1 1 1 2 2 2 0 bZIP transcription factor BMFP PF04380.13 EFE42018.1 - 0.14 12.7 2.1 0.33 11.5 2.1 1.6 1 0 0 1 1 1 0 Membrane fusogenic activity Actin PF00022.19 EFE42019.1 - 1.1e-84 284.5 0.0 6.3e-79 265.5 0.0 2.8 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EFE42019.1 - 0.11 11.3 0.0 0.39 9.5 0.0 1.8 1 1 0 1 1 1 0 MreB/Mbl protein EamA PF00892.20 EFE42020.1 - 1e-05 25.7 1.1 1e-05 25.7 1.1 3.7 3 1 1 4 4 4 3 EamA-like transporter family Aldo_ket_red PF00248.21 EFE42021.1 - 2.5e-52 177.9 0.0 3.4e-52 177.5 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Tubulin PF00091.25 EFE42021.1 - 4.3e-52 177.2 0.4 1.2e-51 175.7 0.4 1.7 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 EFE42021.1 - 0.00075 19.8 0.1 0.0016 18.7 0.1 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain YcaO PF02624.16 EFE42021.1 - 0.084 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 YcaO cyclodehydratase, ATP-ad Mg2+-binding Tubulin_3 PF14881.6 EFE42021.1 - 0.12 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin_C PF03953.17 EFE42022.1 - 2.6e-43 147.2 0.1 3.3e-43 146.8 0.1 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain Hrs_helical PF12210.8 EFE42022.1 - 0.026 15.1 0.1 0.11 13.0 0.0 1.9 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Citrate_bind PF16114.5 EFE42022.1 - 0.13 11.7 0.0 6.5 6.2 0.0 2.1 2 0 0 2 2 2 0 ATP citrate lyase citrate-binding Aa_trans PF01490.18 EFE42024.1 - 2e-32 112.4 31.2 2.9e-32 111.9 31.2 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CAAD PF14159.6 EFE42024.1 - 0.01 15.6 1.1 0.01 15.6 1.1 3.0 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Ipi1_N PF12333.8 EFE42026.1 - 6.7e-28 97.3 0.1 6.7e-28 97.3 0.1 2.3 2 1 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation F-box PF00646.33 EFE42027.1 - 0.00017 21.4 0.2 0.0015 18.3 0.0 2.3 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 EFE42027.1 - 0.092 12.6 0.3 0.27 11.1 0.1 1.9 2 0 0 2 2 2 0 F-box Pyrid_oxidase_2 PF13883.6 EFE42028.1 - 1.6e-35 122.5 0.0 2.5e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 EFE42028.1 - 0.0081 16.3 0.0 0.028 14.6 0.0 1.9 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Smr PF01713.21 EFE42029.1 - 1.1e-10 41.7 0.5 1.1e-10 41.7 0.5 1.9 2 0 0 2 2 2 1 Smr domain DUF1771 PF08590.10 EFE42029.1 - 0.007 16.7 4.7 0.017 15.5 0.5 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF1771) Connexin43 PF03508.13 EFE42029.1 - 0.16 11.5 0.8 0.31 10.6 0.8 1.4 1 0 0 1 1 1 0 Gap junction alpha-1 protein (Cx43) polyprenyl_synt PF00348.17 EFE42030.1 - 1.8e-58 197.6 0.0 2.7e-58 197.1 0.0 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase SQS_PSY PF00494.19 EFE42031.1 - 4.7e-60 203.3 0.2 5.8e-60 203.0 0.2 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase BBIP10 PF14777.6 EFE42031.1 - 0.14 11.7 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 RPE65 PF03055.15 EFE42032.1 - 4.5e-115 385.5 0.0 5.1e-115 385.3 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Amino_oxidase PF01593.24 EFE42033.1 - 6.9e-27 94.8 0.0 1.3e-26 94.0 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFE42033.1 - 2.3e-14 53.3 0.1 8.9e-14 51.5 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFE42033.1 - 9.7e-09 35.3 0.0 5.4e-05 22.9 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFE42033.1 - 1.9e-08 33.9 0.0 3.1e-06 26.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFE42033.1 - 6.5e-07 28.4 0.2 0.0024 16.7 1.5 2.3 2 0 0 2 2 2 2 HI0933-like protein BTB_2 PF02214.22 EFE42033.1 - 1.4e-05 25.3 0.0 4.2e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain FAD_binding_2 PF00890.24 EFE42033.1 - 3.7e-05 23.0 3.9 0.00012 21.3 3.9 1.9 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EFE42033.1 - 0.00013 21.5 4.5 0.00021 20.8 3.9 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFE42033.1 - 0.00069 19.6 0.7 0.012 15.7 0.3 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 EFE42033.1 - 0.00089 18.6 0.3 0.0018 17.6 0.3 1.4 1 0 0 1 1 1 1 Thi4 family BTB PF00651.31 EFE42033.1 - 0.00092 19.4 0.0 0.0023 18.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain GDI PF00996.18 EFE42033.1 - 0.0038 15.8 0.1 0.045 12.3 0.0 2.1 2 0 0 2 2 2 1 GDP dissociation inhibitor FAD_binding_3 PF01494.19 EFE42033.1 - 0.0046 16.3 0.3 0.0084 15.4 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EFE42033.1 - 0.0051 16.1 1.4 0.0051 16.1 1.4 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EFE42033.1 - 0.023 15.1 0.0 0.063 13.7 0.0 1.8 2 0 0 2 2 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 EFE42033.1 - 0.1 13.2 5.4 0.49 11.0 1.9 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EFE42033.1 - 0.12 12.0 0.2 0.22 11.2 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA adh_short PF00106.25 EFE42033.1 - 0.31 10.5 3.5 0.28 10.6 1.8 1.8 2 0 0 2 2 2 0 short chain dehydrogenase Lycopene_cycl PF05834.12 EFE42033.1 - 0.46 9.5 3.5 0.34 9.9 1.2 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 EFE42033.1 - 0.52 9.3 4.7 0.32 10.0 2.9 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A MFS_1 PF07690.16 EFE42034.1 - 4.2e-33 114.7 27.3 6.5e-30 104.2 22.0 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EFE42034.1 - 1.2e-06 27.1 8.9 2e-06 26.4 3.2 2.8 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Mucin15 PF15672.5 EFE42034.1 - 0.45 10.0 3.0 15 4.9 0.1 2.3 2 0 0 2 2 2 0 Cell-membrane associated Mucin15 F-box PF00646.33 EFE42035.1 - 0.014 15.3 0.1 0.06 13.2 0.1 2.1 1 0 0 1 1 1 0 F-box domain EGF_CA PF07645.15 EFE42036.1 - 7.9e-06 26.0 6.0 7.9e-06 26.0 6.0 1.7 2 0 0 2 2 2 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 EFE42036.1 - 0.0007 19.8 2.9 0.0007 19.8 2.9 2.5 2 1 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EFE42036.1 - 0.0011 18.8 1.1 0.0011 18.8 1.1 2.2 2 1 0 2 2 2 1 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 EFE42036.1 - 0.0018 18.5 3.1 0.0046 17.2 3.1 1.7 1 0 0 1 1 1 1 Pvs28 EGF domain EGF_3 PF12947.7 EFE42036.1 - 0.0034 17.5 5.0 0.0034 17.5 5.0 2.1 2 1 0 2 2 2 1 EGF domain EGF PF00008.27 EFE42036.1 - 0.0079 16.5 5.2 0.0079 16.5 5.2 2.1 2 1 0 2 2 2 1 EGF-like domain hEGF PF12661.7 EFE42036.1 - 5.6 7.8 10.0 0.83 10.4 0.8 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF MCM PF00493.23 EFE42037.1 - 6.4e-103 342.7 0.0 1.1e-102 341.9 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFE42037.1 - 3.1e-31 107.8 0.1 5.4e-31 107.1 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFE42037.1 - 1e-21 77.1 0.7 2.8e-21 75.7 0.7 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFE42037.1 - 1.3e-17 64.3 0.4 3.6e-17 62.9 0.4 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFE42037.1 - 3.3e-07 29.9 0.0 4.9e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFE42037.1 - 2e-05 24.6 0.0 5.7e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.6 EFE42037.1 - 0.031 14.9 0.1 0.13 12.9 0.1 2.1 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal AAA_lid_2 PF17863.1 EFE42037.1 - 0.046 13.6 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA lid domain AAA_3 PF07726.11 EFE42037.1 - 0.051 13.4 0.0 0.18 11.7 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PLDc_3 PF13918.6 EFE42037.1 - 0.11 12.1 0.5 37 3.9 0.0 3.2 3 0 0 3 3 3 0 PLD-like domain AAA PF00004.29 EFE42038.1 - 2e-54 183.6 0.0 3.6e-43 147.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EFE42038.1 - 1.7e-30 105.3 0.3 3.8e-30 104.1 0.3 1.7 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 EFE42038.1 - 7.9e-15 54.4 0.1 3e-08 33.4 0.0 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EFE42038.1 - 1.9e-08 34.9 3.4 0.0035 17.7 0.1 4.2 2 2 1 3 3 3 2 AAA ATPase domain NACHT PF05729.12 EFE42038.1 - 7.9e-07 29.1 0.4 0.00042 20.3 0.0 3.4 3 0 0 3 3 3 1 NACHT domain AAA_2 PF07724.14 EFE42038.1 - 8.4e-07 29.3 0.0 0.043 13.9 0.0 2.7 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFE42038.1 - 1.2e-05 25.1 0.0 0.016 14.9 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EFE42038.1 - 5.1e-05 23.3 0.1 0.11 12.5 0.0 2.8 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EFE42038.1 - 6e-05 22.9 0.0 0.04 13.6 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 EFE42038.1 - 0.00011 22.5 1.1 1.2 9.4 0.1 3.7 2 2 1 3 3 3 2 AAA domain AAA_14 PF13173.6 EFE42038.1 - 0.00068 19.7 0.0 0.74 9.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EFE42038.1 - 0.00079 19.4 0.1 2 8.4 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFE42038.1 - 0.00091 18.5 0.0 1.1 8.3 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 EFE42038.1 - 0.0015 19.0 0.0 1.9 9.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EFE42038.1 - 0.0033 16.7 0.0 0.66 9.2 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 EFE42038.1 - 0.0038 17.4 0.0 0.26 11.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFE42038.1 - 0.0038 16.8 0.5 5.8 6.4 0.0 3.1 2 1 1 3 3 3 1 AAA domain RNA_helicase PF00910.22 EFE42038.1 - 0.0099 16.3 0.0 8.1 6.9 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 EFE42038.1 - 0.011 16.0 0.0 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EFE42038.1 - 0.017 14.5 0.4 0.97 8.8 0.1 2.7 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EFE42038.1 - 0.02 13.9 0.1 0.052 12.6 0.1 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein ABC_tran PF00005.27 EFE42038.1 - 0.026 15.0 0.1 5.7 7.5 0.1 2.7 2 0 0 2 2 2 0 ABC transporter KAP_NTPase PF07693.14 EFE42038.1 - 0.039 13.2 0.2 0.25 10.6 0.0 2.1 1 1 1 2 2 2 0 KAP family P-loop domain AAA_7 PF12775.7 EFE42038.1 - 0.051 13.1 0.0 1.2 8.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 EFE42038.1 - 0.082 12.2 0.1 13 5.0 0.0 2.5 2 0 0 2 2 2 0 KaiC Viral_helicase1 PF01443.18 EFE42038.1 - 0.11 12.3 0.0 0.59 9.8 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase APS_kinase PF01583.20 EFE42038.1 - 0.13 12.2 0.1 0.54 10.2 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase Sigma54_activat PF00158.26 EFE42038.1 - 0.16 11.7 0.0 6.7 6.4 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain PEX-2N PF09263.10 EFE42038.1 - 0.21 11.9 0.3 4.5 7.7 0.0 2.5 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal AAA_17 PF13207.6 EFE42038.1 - 0.77 10.2 3.2 3.1 8.2 0.1 3.1 4 0 0 4 4 2 0 AAA domain HisG PF01634.18 EFE42039.1 - 6.8e-55 185.4 0.0 9.4e-55 184.9 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EFE42039.1 - 1.3e-28 98.9 0.3 2.6e-28 98.0 0.3 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 EFE42039.1 - 0.004 17.1 0.0 0.016 15.2 0.0 1.9 1 1 0 1 1 1 1 NMT1/THI5 like MutS_V PF00488.21 EFE42040.1 - 1.8e-73 246.6 0.1 3.5e-73 245.6 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFE42040.1 - 5.1e-34 118.2 0.6 1.4e-33 116.8 0.6 1.8 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EFE42040.1 - 2.4e-19 69.6 0.8 4e-17 62.5 0.8 2.7 1 1 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EFE42040.1 - 3.1e-10 40.4 0.0 1.8e-09 38.0 0.0 2.4 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EFE42040.1 - 1.1e-05 25.6 0.2 2.7e-05 24.4 0.2 1.7 1 0 0 1 1 1 1 MutS family domain IV LpxB PF02684.15 EFE42040.1 - 0.039 12.8 0.0 0.073 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase zf-C2H2_2 PF12756.7 EFE42041.1 - 0.11 12.8 0.2 0.67 10.3 0.1 2.1 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Prenyltrans PF00432.21 EFE42043.1 - 1e-38 130.7 5.6 1.6e-12 46.9 0.0 5.7 5 1 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EFE42043.1 - 1e-05 24.8 0.0 0.0031 16.7 0.0 3.5 2 1 2 4 4 4 2 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EFE42043.1 - 0.013 14.6 0.0 4 6.5 0.0 2.5 2 1 1 3 3 3 0 Squalene-hopene cyclase C-terminal domain RhoGAP PF00620.27 EFE42044.1 - 1.1e-27 96.8 0.0 1.8e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain AAA_6 PF12774.7 EFE42045.1 - 4.4e-124 413.7 0.0 2.3e-123 411.4 0.0 2.3 3 0 0 3 3 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 EFE42045.1 - 1e-122 410.7 7.4 1e-122 410.7 7.4 3.8 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 EFE42045.1 - 5.7e-116 387.9 2.9 5.7e-116 387.9 2.9 4.0 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 EFE42045.1 - 2.1e-74 249.4 1.1 2.1e-74 249.4 1.1 4.5 4 1 0 4 4 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 EFE42045.1 - 4.3e-66 222.9 0.0 1.7e-65 221.0 0.0 2.2 2 0 0 2 2 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EFE42045.1 - 2e-41 141.5 0.0 1.8e-36 125.3 0.0 4.6 4 0 0 4 4 4 2 P-loop containing dynein motor region MT PF12777.7 EFE42045.1 - 4.1e-39 134.6 7.5 7.7e-39 133.7 7.5 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 EFE42045.1 - 4.7e-32 110.9 0.4 1.4e-10 41.3 0.0 6.3 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 EFE42045.1 - 7.6e-32 109.9 0.1 5.6e-27 94.2 0.0 4.5 5 0 0 5 5 4 2 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EFE42045.1 - 6e-27 94.5 0.0 1.5e-26 93.1 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 EFE42045.1 - 5.2e-18 65.4 0.1 8.2e-16 58.3 0.0 3.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EFE42045.1 - 1.5e-15 57.6 0.9 0.0082 16.4 0.0 7.4 7 0 0 7 7 6 2 AAA domain AAA PF00004.29 EFE42045.1 - 2.6e-14 53.8 0.0 0.0004 20.8 0.0 4.7 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFE42045.1 - 1.1e-09 39.0 0.8 0.079 13.5 0.0 5.5 5 0 0 5 5 4 2 AAA domain AAA_16 PF13191.6 EFE42045.1 - 1.5e-09 38.5 4.5 1.2 9.5 0.0 7.8 7 0 0 7 7 6 2 AAA ATPase domain AAA_33 PF13671.6 EFE42045.1 - 4e-09 36.8 5.6 0.098 12.8 0.0 5.6 6 0 0 6 6 5 3 AAA domain AAA_lid_1 PF17857.1 EFE42045.1 - 8e-07 29.2 0.5 7.8e-05 22.8 0.0 3.5 3 0 0 3 3 2 1 AAA+ lid domain ABC_tran PF00005.27 EFE42045.1 - 2.9e-05 24.6 0.1 2.5 8.6 0.0 5.0 3 0 0 3 3 3 1 ABC transporter T2SSE PF00437.20 EFE42045.1 - 4.6e-05 22.6 0.0 0.034 13.2 0.0 2.9 2 0 0 2 2 2 1 Type II/IV secretion system protein Mg_chelatase PF01078.21 EFE42045.1 - 5e-05 22.8 1.0 0.66 9.3 0.0 4.1 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EFE42045.1 - 0.00048 19.8 0.1 2.3 8.0 0.0 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFE42045.1 - 0.00065 19.5 0.6 38 3.9 0.0 4.8 4 0 0 4 4 4 0 AAA domain RsgA_GTPase PF03193.16 EFE42045.1 - 0.00079 19.4 0.0 12 5.7 0.0 4.3 4 0 0 4 4 4 0 RsgA GTPase AAA_19 PF13245.6 EFE42045.1 - 0.0021 18.4 2.4 0.28 11.5 0.0 4.1 4 0 0 4 4 4 1 AAA domain AAA_25 PF13481.6 EFE42045.1 - 0.0029 17.2 0.0 0.32 10.5 0.0 3.3 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFE42045.1 - 0.0033 17.2 0.5 11 5.7 0.0 4.2 4 0 0 4 4 3 0 AAA domain IstB_IS21 PF01695.17 EFE42045.1 - 0.004 16.9 0.6 0.61 9.8 0.0 4.1 4 0 0 4 4 4 1 IstB-like ATP binding protein Zeta_toxin PF06414.12 EFE42045.1 - 0.0075 15.6 0.5 3.8 6.8 0.2 3.9 4 0 0 4 4 4 1 Zeta toxin FtsK_SpoIIIE PF01580.18 EFE42045.1 - 0.0075 15.6 3.8 2.1 7.7 0.0 4.3 5 0 0 5 5 4 1 FtsK/SpoIIIE family Rad17 PF03215.15 EFE42045.1 - 0.01 15.8 0.2 6.7 6.6 0.0 4.3 5 0 0 5 5 4 0 Rad17 P-loop domain RNA_helicase PF00910.22 EFE42045.1 - 0.014 15.7 0.1 33 4.9 0.0 4.5 4 0 0 4 4 4 0 RNA helicase Phage_GP20 PF06810.11 EFE42045.1 - 0.062 13.1 15.3 4.6 7.0 9.2 4.2 2 1 0 2 2 2 0 Phage minor structural protein GP20 MEDS PF14417.6 EFE42045.1 - 0.22 11.4 2.4 0.39 10.5 0.1 2.8 2 0 0 2 2 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain PduV-EutP PF10662.9 EFE42045.1 - 0.38 10.5 1.7 11 5.7 0.1 4.0 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation DUF4482 PF14818.6 EFE42045.1 - 1.8 9.4 17.2 17 6.3 8.8 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4482) Ribonuclease_3 PF00636.26 EFE42046.1 - 1.3e-40 138.2 0.0 2.1e-19 70.1 0.0 3.0 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFE42046.1 - 4.8e-23 81.7 0.0 6.5e-12 45.7 0.0 3.5 2 1 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.14 EFE42046.1 - 1.1e-20 73.6 0.2 1.1e-18 67.1 0.1 3.0 1 1 1 2 2 2 1 Dicer dimerisation domain ResIII PF04851.15 EFE42046.1 - 4.8e-13 49.5 0.3 1.2e-12 48.1 0.3 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFE42046.1 - 2.2e-08 34.1 0.0 4.8e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.26 EFE42046.1 - 0.0046 17.6 0.1 1.4 9.7 0.0 2.8 2 0 0 2 2 2 1 Double-stranded RNA binding motif AAA_22 PF13401.6 EFE42046.1 - 0.13 12.6 0.1 0.65 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain TAP42 PF04177.12 EFE42047.1 - 6.9e-106 354.0 3.9 7.8e-106 353.8 3.9 1.0 1 0 0 1 1 1 1 TAP42-like family Lipase_GDSL PF00657.22 EFE42048.1 - 4.3e-07 30.1 0.0 5.6e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EFE42048.1 - 0.00021 21.7 0.0 0.002 18.5 0.0 2.2 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family PRP21_like_P PF12230.8 EFE42048.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein Porphobil_deam PF01379.20 EFE42049.1 - 8.9e-74 247.4 0.1 1.1e-73 247.1 0.1 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EFE42049.1 - 4.4e-19 68.6 0.5 7.6e-19 67.9 0.5 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Lon_C PF05362.13 EFE42050.1 - 7.2e-68 228.2 0.4 1.5e-67 227.1 0.4 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EFE42050.1 - 6.9e-25 88.1 0.1 1.7e-24 86.9 0.1 1.7 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EFE42050.1 - 4.5e-24 85.4 0.0 3.2e-23 82.6 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFE42050.1 - 1e-07 32.0 0.0 3.7e-07 30.2 0.0 2.0 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EFE42050.1 - 2.3e-07 30.7 0.0 5.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EFE42050.1 - 2e-06 28.3 0.1 1e-05 26.0 0.1 2.2 1 0 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 EFE42050.1 - 7.6e-06 25.8 0.0 2.2e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EFE42050.1 - 2e-05 24.0 0.0 4.4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_3 PF07726.11 EFE42050.1 - 6.5e-05 22.8 0.0 0.00018 21.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFE42050.1 - 0.00032 20.5 0.1 0.0012 18.6 0.0 2.0 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFE42050.1 - 0.00067 19.8 0.0 0.0039 17.3 0.0 2.4 1 1 1 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFE42050.1 - 0.001 19.4 0.2 0.011 16.0 0.0 2.7 2 1 1 3 3 2 1 AAA domain Birna_VP4 PF01768.16 EFE42050.1 - 0.0052 16.6 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Birnavirus VP4 protein AAA_33 PF13671.6 EFE42050.1 - 0.0064 16.7 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFE42050.1 - 0.013 15.5 0.0 0.047 13.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFE42050.1 - 0.013 15.8 0.0 0.054 13.9 0.0 2.1 1 0 0 1 1 1 0 RNA helicase Rad17 PF03215.15 EFE42050.1 - 0.015 15.3 0.1 0.08 12.9 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_7 PF12775.7 EFE42050.1 - 0.02 14.4 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EFE42050.1 - 0.023 14.1 0.1 0.058 12.8 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFE42050.1 - 0.029 14.9 0.1 0.085 13.4 0.1 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFE42050.1 - 0.036 14.0 0.0 0.12 12.3 0.0 1.9 1 0 0 1 1 1 0 NACHT domain TniB PF05621.11 EFE42050.1 - 0.038 13.4 0.0 0.19 11.1 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 EFE42050.1 - 0.038 14.3 0.6 0.21 11.9 0.3 2.5 2 1 0 2 2 1 0 AAA domain AAA_PrkA PF08298.11 EFE42050.1 - 0.043 12.7 0.1 0.34 9.8 0.0 2.0 1 1 0 2 2 2 0 PrkA AAA domain PhoH PF02562.16 EFE42050.1 - 0.044 13.2 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein TsaE PF02367.17 EFE42050.1 - 0.048 13.7 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EFE42050.1 - 0.055 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EFE42050.1 - 0.078 12.7 0.1 0.078 12.7 0.1 2.2 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 EFE42050.1 - 0.094 12.4 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFE42050.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EFE42050.1 - 0.12 11.5 0.0 0.27 10.4 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 EFE42050.1 - 0.13 11.5 0.1 0.28 10.4 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_23 PF13476.6 EFE42050.1 - 0.14 12.6 0.1 0.14 12.6 0.1 3.0 1 1 1 2 2 1 0 AAA domain ABC_tran PF00005.27 EFE42050.1 - 0.24 11.9 0.1 0.24 11.9 0.1 2.7 1 1 1 2 2 2 0 ABC transporter Laps PF10169.9 EFE42050.1 - 1.1 9.9 3.5 3.9 8.1 0.0 2.5 1 1 1 2 2 2 0 Learning-associated protein Ribosomal_L23 PF00276.20 EFE42051.1 - 0.00013 22.2 0.3 0.0002 21.7 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L23 RIO1 PF01163.22 EFE42052.1 - 4.6e-41 140.5 0.2 2.4e-28 99.0 0.0 2.2 2 0 0 2 2 2 2 RIO1 family APH PF01636.23 EFE42052.1 - 1.3e-06 28.5 0.0 0.0084 16.1 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EFE42052.1 - 2.2e-05 23.9 0.0 0.001 18.5 0.0 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Rio2_N PF09202.11 EFE42052.1 - 3.9e-05 23.8 0.8 0.00015 21.9 1.2 1.7 2 0 0 2 2 2 1 Rio2, N-terminal Chs7 PF12271.8 EFE42053.1 - 2.7e-123 410.9 15.7 3.2e-123 410.7 15.7 1.1 1 0 0 1 1 1 1 Chitin synthase export chaperone Ribosomal_L27A PF00828.19 EFE42054.1 - 2.8e-30 105.6 0.4 4.9e-30 104.8 0.4 1.4 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Pkinase PF00069.25 EFE42055.1 - 1e-46 159.4 0.0 1.5e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42055.1 - 4.1e-27 95.1 0.0 4.4e-21 75.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE42055.1 - 0.0039 16.0 0.0 0.0068 15.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase SelP_N PF04592.14 EFE42055.1 - 0.27 10.6 17.0 0.44 9.9 17.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.22 EFE42055.1 - 1.2 8.3 2.4 1.7 7.8 2.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Radial_spoke PF04712.12 EFE42057.1 - 0.028 13.4 9.6 0.029 13.3 9.6 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein Myc_N PF01056.18 EFE42057.1 - 0.58 10.0 12.0 0.63 9.9 12.0 1.2 1 0 0 1 1 1 0 Myc amino-terminal region FAM176 PF14851.6 EFE42057.1 - 0.62 9.7 16.8 0.84 9.3 16.8 1.2 1 0 0 1 1 1 0 FAM176 family D123 PF07065.14 EFE42057.1 - 1.7 7.7 7.4 2.1 7.4 7.4 1.1 1 0 0 1 1 1 0 D123 PAXIP1_C PF15364.6 EFE42057.1 - 1.8 8.9 17.0 2.3 8.5 17.0 1.2 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein DUF2052 PF09747.9 EFE42057.1 - 3.2 7.8 21.1 3.6 7.7 21.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Sporozoite_P67 PF05642.11 EFE42057.1 - 3.7 5.5 9.2 3.8 5.5 9.2 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 EFE42057.1 - 5.5 5.0 16.4 5.8 4.9 16.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Cytomega_UL84 PF06284.11 EFE42057.1 - 8.4 4.7 11.1 9.5 4.5 11.1 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein SH3_1 PF00018.28 EFE42058.1 - 2e-05 24.1 0.0 3.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE42058.1 - 0.0073 16.1 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_16 PF18348.1 EFE42058.1 - 0.035 13.9 0.1 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain RCC1_2 PF13540.6 EFE42059.1 - 9.3e-15 54.0 1.1 3.7e-08 33.0 0.1 3.4 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 EFE42059.1 - 2.7e-08 33.6 0.1 5.4e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 F-box-like PQ-loop PF04193.14 EFE42060.1 - 7.6e-37 124.9 12.5 2.5e-18 65.6 1.7 2.7 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 EFE42060.1 - 0.0026 17.8 8.0 0.016 15.2 0.2 2.7 3 0 0 3 3 3 2 Sugar efflux transporter for intercellular exchange Aminotran_1_2 PF00155.21 EFE42062.1 - 3.3e-63 214.0 0.0 4.7e-63 213.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Tmemb_18A PF09771.9 EFE42062.1 - 0.0043 17.4 0.0 0.0079 16.6 0.0 1.4 1 0 0 1 1 1 1 Transmembrane protein 188 Beta_elim_lyase PF01212.21 EFE42062.1 - 0.011 15.1 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase AMP-binding PF00501.28 EFE42063.1 - 1.9e-35 122.3 0.0 4e-35 121.2 0.0 1.4 1 1 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EFE42063.1 - 1.2e-09 38.0 1.4 4.4e-09 36.1 0.2 2.2 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Peptidase_M16_C PF05193.21 EFE42064.1 - 1.5e-48 165.3 0.0 3.6e-48 164.0 0.0 1.7 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFE42064.1 - 2.6e-40 137.8 0.0 3.3e-39 134.3 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) TRPM_tetra PF16519.5 EFE42064.1 - 0.18 11.9 1.0 0.57 10.3 1.0 1.8 1 0 0 1 1 1 0 Tetramerisation domain of TRPM Abhydrolase_2 PF02230.16 EFE42065.1 - 5.6e-26 91.7 0.0 5e-17 62.4 0.0 2.4 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EFE42065.1 - 0.00019 20.8 0.0 0.0033 16.7 0.0 2.3 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFE42065.1 - 0.0021 17.6 0.0 0.0033 16.9 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 EFE42065.1 - 0.0057 16.3 0.0 0.014 15.1 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 EFE42065.1 - 0.01 15.7 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DLH PF01738.18 EFE42065.1 - 0.2 11.2 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Tom22 PF04281.13 EFE42066.1 - 3e-48 163.1 0.2 3.5e-48 162.9 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DUF4211 PF13926.6 EFE42067.1 - 7.7e-44 149.3 0.0 1.5e-43 148.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) DUF4449 PF14613.6 EFE42068.1 - 6.3e-63 211.7 0.6 6.3e-63 211.7 0.6 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF4449) Peptidase_M35 PF02102.15 EFE42069.1 - 1.5e-72 244.5 0.0 1.8e-72 244.2 0.0 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EFE42069.1 - 4.6e-34 118.1 0.1 7.6e-34 117.3 0.1 1.3 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase OmdA PF13376.6 EFE42069.1 - 0.027 14.5 1.0 0.062 13.3 0.5 1.9 1 1 1 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated HRXXH PF13933.6 EFE42069.1 - 0.16 11.5 0.1 0.44 10.1 0.1 1.7 1 1 0 1 1 1 0 Putative peptidase family vWA-TerF-like PF10138.9 EFE42072.1 - 5.8e-08 33.1 0.0 8.8e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EFE42072.1 - 0.08 13.2 0.1 0.16 12.2 0.1 1.5 1 1 0 1 1 1 0 von Willebrand factor type A domain Acetyltransf_1 PF00583.25 EFE42073.1 - 0.00029 21.1 0.0 0.0005 20.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_13 PF13880.6 EFE42073.1 - 0.012 15.6 0.1 0.026 14.5 0.1 1.6 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_7 PF13508.7 EFE42073.1 - 0.062 13.7 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFE42073.1 - 0.085 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF5368 PF17336.2 EFE42073.1 - 0.097 12.8 2.8 0.16 12.1 2.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5368) Svf1_C PF17187.4 EFE42074.1 - 6.3e-59 198.5 0.0 1.5e-58 197.3 0.0 1.6 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EFE42074.1 - 6.1e-55 185.7 0.0 9e-55 185.2 0.0 1.2 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain MFMR PF07777.11 EFE42074.1 - 0.044 14.3 1.0 1.9 9.1 0.1 3.3 2 1 0 2 2 2 0 G-box binding protein MFMR Pkinase PF00069.25 EFE42076.1 - 8.4e-47 159.7 0.0 4.4e-46 157.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42076.1 - 2.4e-21 76.2 0.0 3.7e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE42076.1 - 0.0046 16.9 0.0 0.009 16.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFE42076.1 - 0.011 15.1 0.0 0.024 14.0 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 EFE42076.1 - 0.023 13.7 0.0 0.05 12.5 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EFE42076.1 - 0.096 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3337 PF11816.8 EFE42077.1 - 1.4e-55 187.8 0.0 2.9e-55 186.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EFE42077.1 - 4.7e-21 74.7 19.6 9.8e-05 23.1 0.3 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE42077.1 - 0.0001 22.5 0.3 0.23 11.8 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE42077.1 - 0.00047 18.9 2.4 0.016 13.9 0.1 2.9 3 0 0 3 3 3 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EFE42077.1 - 0.19 10.6 0.9 3.2 6.6 0.4 2.7 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Mito_carr PF00153.27 EFE42078.1 - 1.1e-45 153.4 3.7 3.3e-20 71.8 0.0 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein ATP_bind_3 PF01171.20 EFE42079.1 - 1.5e-26 93.2 0.0 7.1e-26 91.1 0.0 2.0 1 1 0 1 1 1 1 PP-loop family RhoGEF PF00621.20 EFE42080.1 - 1.3e-18 67.9 0.0 2.6e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DUF3507 PF12015.8 EFE42080.1 - 0.00013 21.7 0.0 0.00024 20.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) DivIVA PF05103.13 EFE42080.1 - 0.037 14.1 4.2 0.099 12.7 4.2 1.7 1 0 0 1 1 1 0 DivIVA protein Nod1 PF17114.5 EFE42080.1 - 0.059 13.5 0.0 0.84 9.8 0.0 2.6 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 Exonuc_VII_L PF02601.15 EFE42080.1 - 5.5 6.5 7.6 13 5.3 7.6 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 EFE42080.1 - 6.3 7.1 5.2 1.6 9.0 1.2 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Sec7 PF01369.20 EFE42081.1 - 2.2e-60 203.5 0.0 3.6e-60 202.8 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EFE42081.1 - 6e-23 81.5 0.0 4.2e-20 72.2 0.0 3.1 2 1 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EFE42081.1 - 0.00058 19.6 0.5 0.002 17.8 0.5 1.9 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 TPR_14 PF13428.6 EFE42082.1 - 3.5e-13 49.2 13.1 1.3 10.0 0.0 10.7 8 2 3 11 11 11 3 Tetratricopeptide repeat Suf PF05843.14 EFE42082.1 - 3.1e-11 43.8 10.7 0.0061 16.6 0.2 5.9 3 1 1 5 5 5 4 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EFE42082.1 - 6.8e-08 32.9 2.1 0.54 10.8 0.0 6.2 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFE42082.1 - 7.4e-08 32.0 4.7 0.32 11.3 0.0 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFE42082.1 - 1.5e-06 27.7 4.8 0.00043 19.6 0.2 4.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFE42082.1 - 1.6e-06 28.3 4.3 28 5.1 0.0 7.1 6 1 0 6 6 6 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EFE42082.1 - 1e-05 25.5 10.7 0.85 9.6 0.1 7.1 6 2 1 7 7 7 2 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 EFE42082.1 - 3.3e-05 23.7 13.1 3.1 8.1 0.0 7.4 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFE42082.1 - 0.00038 20.6 3.3 1.2 9.6 0.0 6.7 7 0 0 7 7 6 1 Tetratricopeptide repeat HAT PF02184.16 EFE42082.1 - 0.0028 17.6 2.7 2.1 8.4 0.1 5.4 5 0 0 5 5 5 1 HAT (Half-A-TPR) repeat TPR_1 PF00515.28 EFE42082.1 - 0.0075 16.1 0.0 4.8 7.2 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE42082.1 - 0.038 13.7 0.2 0.51 10.1 0.1 3.2 3 1 0 3 3 3 0 TPR repeat PPR PF01535.20 EFE42082.1 - 0.24 11.8 0.7 1.5e+02 3.0 0.0 4.6 4 0 0 4 4 4 0 PPR repeat TPR_10 PF13374.6 EFE42082.1 - 0.35 10.8 10.0 59 3.7 0.0 6.8 8 0 0 8 8 8 0 Tetratricopeptide repeat ATP-synt_D PF01813.17 EFE42083.1 - 6.1e-46 156.7 3.1 6.1e-46 156.7 3.1 2.4 1 1 1 2 2 2 1 ATP synthase subunit D MIS13 PF08202.11 EFE42083.1 - 0.00091 18.6 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Mis12-Mtw1 protein family APG6_N PF17675.1 EFE42083.1 - 0.0067 17.0 0.8 0.016 15.7 0.8 1.6 1 0 0 1 1 1 1 Apg6 coiled-coil region RRM_1 PF00076.22 EFE42084.1 - 1.8e-26 91.7 0.5 8.6e-12 44.7 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFE42084.1 - 0.0012 18.5 0.0 0.026 14.1 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFE42084.1 - 0.0081 16.0 0.0 2.1 8.3 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif TFCD_C PF12612.8 EFE42085.1 - 1.9e-29 102.8 0.0 4.4e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT PF02985.22 EFE42085.1 - 2.3e-05 24.2 0.7 1.7 9.1 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EFE42085.1 - 0.0013 19.2 0.9 1.9 9.0 0.0 4.4 3 0 0 3 3 3 1 HEAT-like repeat HEAT_2 PF13646.6 EFE42085.1 - 0.013 15.9 0.2 2.4 8.6 0.1 3.5 3 0 0 3 3 3 0 HEAT repeats IFRD PF05004.13 EFE42085.1 - 0.072 12.2 0.1 0.18 10.9 0.1 1.6 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) EH_Signature PF15611.6 EFE42085.1 - 0.094 12.1 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 EH_Signature domain Cnd1 PF12717.7 EFE42085.1 - 0.24 11.4 1.6 22 5.0 0.1 4.1 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Pkinase PF00069.25 EFE42087.1 - 2.5e-60 204.1 0.0 6.2e-60 202.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42087.1 - 4.1e-35 121.3 0.0 7e-35 120.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 EFE42087.1 - 3.6e-29 100.7 14.1 3.1e-15 56.0 4.5 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 EFE42087.1 - 8.7e-20 70.4 30.7 8.5e-12 44.8 9.0 2.8 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EFE42087.1 - 5.9e-08 33.3 0.1 3.2e-07 30.9 0.1 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 EFE42087.1 - 1.3e-07 31.8 0.0 2.9e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 EFE42087.1 - 0.029 13.7 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like TFIIA PF03153.13 EFE42087.1 - 1.9 8.4 29.6 0.33 10.9 25.4 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit zf-RING_9 PF13901.6 EFE42087.1 - 2.8 7.9 22.2 1.6 8.6 7.7 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Uds1 PF15456.6 EFE42087.1 - 3.7 7.7 5.9 1.3 9.2 0.9 2.4 2 0 0 2 2 2 0 Up-regulated During Septation eIF-1a PF01176.19 EFE42088.1 - 4.3e-20 71.3 0.0 5.3e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 ALG3 PF05208.13 EFE42089.1 - 1.5e-122 409.5 19.6 1.7e-122 409.3 19.6 1.0 1 0 0 1 1 1 1 ALG3 protein DUF4646 PF15496.6 EFE42090.1 - 7.1e-19 68.7 0.0 1.1e-18 68.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) COA2 PF17051.5 EFE42091.1 - 0.059 13.4 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase assembly factor 2 Metallophos PF00149.28 EFE42092.1 - 1.5e-31 110.5 0.0 6.3e-22 79.1 0.0 2.1 1 1 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFE42092.1 - 0.092 13.2 0.1 0.24 11.9 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Fungal_trans PF04082.18 EFE42093.1 - 7.2e-41 140.0 0.3 7.3e-31 107.2 0.1 2.7 2 0 0 2 2 2 2 Fungal specific transcription factor domain DNA_ligase_A_M PF01068.21 EFE42094.1 - 8e-48 162.8 0.0 5.7e-47 160.0 0.0 2.4 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFE42094.1 - 1e-40 139.9 0.0 2.3e-40 138.7 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus BRCT_2 PF16589.5 EFE42094.1 - 2.5e-18 66.2 0.8 1.2e-09 38.5 0.2 2.7 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 EFE42094.1 - 3.3e-18 66.5 0.0 6e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_C PF04679.15 EFE42094.1 - 1.5e-17 64.0 0.0 4.7e-17 62.4 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region LIG3_BRCT PF16759.5 EFE42094.1 - 6.4e-09 36.0 1.2 0.0036 17.6 0.1 2.7 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain BRCT PF00533.26 EFE42094.1 - 1.8e-07 31.4 1.4 0.0013 19.1 0.0 3.2 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EFE42094.1 - 0.00066 19.5 0.1 0.071 13.0 0.1 2.5 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 EFE42094.1 - 0.004 17.1 0.1 0.8 9.7 0.0 2.6 2 0 0 2 2 2 1 twin BRCT domain DNA_ligase_IV PF11411.8 EFE42094.1 - 0.011 15.9 0.2 0.023 14.8 0.2 1.5 1 0 0 1 1 1 0 DNA ligase IV Pkinase PF00069.25 EFE42095.1 - 8e-70 235.2 0.0 1e-69 234.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42095.1 - 6.8e-33 114.0 0.0 9.2e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EFE42095.1 - 7.6e-09 36.1 3.0 2.1e-08 34.8 3.0 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EFE42095.1 - 1.1e-05 24.6 0.1 1.7e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFE42095.1 - 0.046 13.0 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 EFE42095.1 - 0.08 12.6 0.1 0.86 9.2 0.1 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 EF-hand_4 PF12763.7 EFE42096.1 - 0.00086 19.2 0.1 0.0017 18.3 0.1 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Spb1_C PF07780.12 EFE42098.1 - 1.2e-86 289.7 16.2 1.2e-86 289.7 16.2 2.8 4 0 0 4 4 4 1 Spb1 C-terminal domain DUF3381 PF11861.8 EFE42098.1 - 1.4e-51 174.6 9.7 1.4e-51 174.6 9.7 4.4 5 0 0 5 5 5 2 Domain of unknown function (DUF3381) FtsJ PF01728.19 EFE42098.1 - 2.3e-38 132.1 0.4 1.8e-33 116.2 0.0 2.5 1 1 1 2 2 2 2 FtsJ-like methyltransferase KCT2 PF17818.1 EFE42098.1 - 2 8.5 14.4 3.5 7.7 3.7 2.5 2 0 0 2 2 2 0 Keratinocyte-associated gene product PcfJ PF14284.6 EFE42098.1 - 4.7 7.1 7.2 0.48 10.3 1.5 2.3 2 0 0 2 2 2 0 PcfJ-like protein EamA PF00892.20 EFE42099.1 - 1.9e-10 41.1 22.9 1.2e-07 32.0 4.7 3.1 3 0 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 EFE42099.1 - 7.2e-09 35.6 3.8 9.3e-09 35.2 1.4 1.9 2 0 0 2 2 2 1 Solute carrier family 35 PUNUT PF16913.5 EFE42099.1 - 1.3e-05 24.6 0.7 1.3e-05 24.6 0.7 1.6 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport DUF3955 PF13127.6 EFE42099.1 - 0.00018 21.3 1.0 0.00018 21.3 1.0 3.6 4 1 0 4 4 4 1 Protein of unknown function (DUF3955) TPT PF03151.16 EFE42099.1 - 0.016 14.6 3.6 0.14 11.5 1.4 2.2 2 0 0 2 2 2 0 Triose-phosphate Transporter family UAA PF08449.11 EFE42099.1 - 0.026 13.7 4.9 0.0099 15.1 2.2 1.6 2 0 0 2 2 2 0 UAA transporter family DUF2981 PF11200.8 EFE42099.1 - 0.04 13.7 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) IMPa_N_2 PF18650.1 EFE42099.1 - 0.1 11.8 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Immunomodulating metalloprotease N-terminal domain Ras PF00071.22 EFE42100.1 - 8e-55 184.8 0.2 1e-54 184.5 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE42100.1 - 1.5e-30 105.9 0.0 2.2e-30 105.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE42100.1 - 6.1e-13 48.6 0.0 8.5e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFE42100.1 - 2.6e-07 30.7 0.0 4.1e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFE42100.1 - 2.6e-06 27.0 0.0 3.4e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFE42100.1 - 8.2e-06 25.5 0.0 0.0002 21.0 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFE42100.1 - 0.00018 21.5 0.2 0.0031 17.4 0.1 2.2 1 1 2 3 3 3 1 RsgA GTPase AAA_7 PF12775.7 EFE42100.1 - 0.012 15.1 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 EFE42100.1 - 0.015 14.9 0.0 0.035 13.7 0.0 1.6 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 EFE42100.1 - 0.018 14.4 0.1 0.072 12.4 0.0 1.9 2 0 0 2 2 2 0 Septin AAA_5 PF07728.14 EFE42100.1 - 0.02 14.9 0.0 0.039 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFE42100.1 - 0.02 15.1 0.0 0.038 14.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EFE42100.1 - 0.021 14.6 0.1 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EFE42100.1 - 0.023 14.1 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EFE42100.1 - 0.033 14.6 0.0 0.056 13.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain MCM PF00493.23 EFE42100.1 - 0.048 12.7 0.0 0.082 12.0 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_24 PF13479.6 EFE42100.1 - 0.083 12.6 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EFE42100.1 - 0.12 12.2 1.0 0.17 11.8 0.1 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EFE42100.1 - 0.13 12.2 0.1 0.26 11.2 0.0 1.5 2 0 0 2 2 1 0 NACHT domain NTPase_1 PF03266.15 EFE42100.1 - 0.18 11.7 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 NTPase ATG16 PF08614.11 EFE42101.1 - 7.3e-48 163.5 18.9 8.2e-48 163.3 18.9 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) CCDC144C PF14915.6 EFE42101.1 - 0.00055 19.2 9.7 0.00055 19.2 9.7 1.4 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region UPF0242 PF06785.11 EFE42101.1 - 0.041 14.0 13.2 0.065 13.3 4.1 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3496 PF12001.8 EFE42101.1 - 0.091 13.1 2.1 0.17 12.3 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) DUF948 PF06103.11 EFE42101.1 - 0.18 12.1 3.4 2.2 8.6 3.4 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) GvpG PF05120.12 EFE42101.1 - 0.49 10.4 6.0 0.16 12.0 2.1 2.2 1 1 2 3 3 3 0 Gas vesicle protein G DUF4407 PF14362.6 EFE42101.1 - 0.53 9.6 10.5 0.85 8.9 10.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sec2p PF06428.11 EFE42101.1 - 0.57 10.2 11.1 0.98 9.4 9.7 2.1 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p FAM76 PF16046.5 EFE42101.1 - 0.88 8.9 6.7 1.1 8.6 6.7 1.1 1 0 0 1 1 1 0 FAM76 protein Spc7 PF08317.11 EFE42101.1 - 0.98 8.2 15.5 0.053 12.4 10.1 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein Med9 PF07544.13 EFE42101.1 - 2 8.6 6.9 1.2 9.2 4.4 1.9 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 TMF_TATA_bd PF12325.8 EFE42101.1 - 8.2 6.7 17.0 3.1 8.1 1.7 3.3 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DOT1 PF08123.13 EFE42102.1 - 1.4e-76 256.6 0.0 2.2e-76 256.0 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 EFE42102.1 - 0.0011 19.6 0.1 0.0064 17.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain NAD_binding_10 PF13460.6 EFE42102.1 - 0.027 14.4 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Methyltransf_31 PF13847.6 EFE42102.1 - 0.065 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain NmrA PF05368.13 EFE42102.1 - 0.12 12.0 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family PH PF00169.29 EFE42103.1 - 1.9e-27 95.8 1.5 3.5e-13 50.0 0.1 2.2 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 EFE42103.1 - 1.6e-11 44.6 4.4 1.5e-06 28.6 0.2 3.7 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EFE42103.1 - 1.9e-07 31.5 5.7 0.0047 17.3 0.1 3.2 2 2 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.6 EFE42103.1 - 0.00031 21.0 0.0 0.012 15.9 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PBP_N PF17093.5 EFE42103.1 - 0.0016 18.7 0.1 0.0034 17.6 0.1 1.5 1 0 0 1 1 1 1 Penicillin-binding protein N-terminus PH_2 PF08458.10 EFE42103.1 - 0.13 12.6 1.0 3.3 8.1 0.0 2.6 3 1 0 3 3 3 0 Plant pleckstrin homology-like region Glyco_transf_15 PF01793.16 EFE42104.1 - 1.5e-64 218.3 13.3 1.5e-33 116.5 0.1 3.7 1 1 2 3 3 3 3 Glycolipid 2-alpha-mannosyltransferase Abhydrolase_1 PF00561.20 EFE42105.1 - 2.7e-18 66.5 0.0 4.6e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE42105.1 - 3.9e-16 59.0 0.0 6.2e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFE42105.1 - 1e-12 49.2 3.1 1e-12 49.1 0.2 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase PF00756.20 EFE42105.1 - 6.9e-05 22.6 0.0 0.00017 21.3 0.0 1.6 2 0 0 2 2 2 1 Putative esterase DUF915 PF06028.11 EFE42105.1 - 0.00048 19.5 0.0 0.0009 18.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) LIDHydrolase PF10230.9 EFE42105.1 - 0.0032 17.0 0.0 0.0057 16.2 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Chlorophyllase2 PF12740.7 EFE42105.1 - 0.0059 15.5 0.0 0.0082 15.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EFE42105.1 - 0.0099 14.9 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Abhydrolase_5 PF12695.7 EFE42105.1 - 0.034 13.9 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EFE42105.1 - 0.035 14.0 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Thioesterase PF00975.20 EFE42105.1 - 0.037 14.1 0.3 0.18 11.9 0.3 2.0 1 1 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.25 EFE42105.1 - 0.044 13.7 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_2 PF02230.16 EFE42105.1 - 0.046 13.5 0.0 3 7.6 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EFE42105.1 - 0.086 12.3 0.0 0.32 10.4 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Spo7 PF03907.13 EFE42106.1 - 1.1e-89 299.7 0.0 1.5e-89 299.3 0.0 1.2 1 0 0 1 1 1 1 Spo7-like protein YL1 PF05764.13 EFE42106.1 - 0.52 10.4 4.9 1.1 9.3 4.9 1.5 1 0 0 1 1 1 0 YL1 nuclear protein HNH_2 PF13391.6 EFE42107.1 - 0.00012 22.1 0.0 0.00028 21.0 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease AHH PF14412.6 EFE42107.1 - 0.028 14.5 0.6 0.25 11.4 0.0 2.6 3 0 0 3 3 3 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH MCM PF00493.23 EFE42108.1 - 7.1e-98 326.2 0.1 1e-97 325.6 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 EFE42108.1 - 1.6e-24 86.2 0.6 6.6e-24 84.1 0.6 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_OB PF17207.3 EFE42108.1 - 2.6e-11 43.5 0.0 5.7e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 EFE42108.1 - 6.1e-07 29.0 0.0 9.8e-06 25.1 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EFE42108.1 - 0.0021 17.9 0.0 0.0049 16.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFE42108.1 - 0.068 12.9 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF4677 PF15726.5 EFE42108.1 - 0.14 12.3 2.2 0.35 11.0 2.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) BUD22 PF09073.10 EFE42108.1 - 0.47 9.7 16.4 0.71 9.1 16.4 1.2 1 0 0 1 1 1 0 BUD22 DUF5521 PF17659.1 EFE42108.1 - 4.5 5.0 5.2 6.6 4.5 5.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5521) PPR PF01535.20 EFE42109.1 - 5e-19 67.2 2.2 5e-05 23.3 0.0 8.5 8 0 0 8 8 8 5 PPR repeat PPR_2 PF13041.6 EFE42109.1 - 3.5e-17 62.3 5.7 3.2e-09 36.8 0.0 6.5 4 1 3 7 7 7 2 PPR repeat family PPR_3 PF13812.6 EFE42109.1 - 4.1e-17 62.0 0.5 3.7e-07 30.1 0.0 5.3 3 2 2 5 5 5 4 Pentatricopeptide repeat domain PPR_long PF17177.4 EFE42109.1 - 6.8e-11 41.9 0.0 5.8e-05 22.6 0.0 3.2 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EFE42109.1 - 3.4e-06 26.7 0.0 2.1 8.1 0.0 5.5 6 0 0 6 6 6 2 PPR repeat SRP68 PF16969.5 EFE42110.1 - 1.5e-185 618.4 0.7 1.7e-185 618.3 0.7 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 RRM_Rrp7 PF17799.1 EFE42112.1 - 9.6e-30 103.5 0.0 1.5e-29 102.9 0.0 1.3 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 EFE42112.1 - 8.4e-28 96.9 7.7 8.4e-28 96.9 7.7 2.1 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Secretin_N_2 PF07655.13 EFE42112.1 - 1.3 9.7 6.2 0.67 10.5 1.7 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Rad51 PF08423.11 EFE42113.1 - 2.8e-53 180.8 0.0 9.5e-46 156.1 0.0 2.1 2 0 0 2 2 2 2 Rad51 HHH_5 PF14520.6 EFE42113.1 - 4e-08 33.7 0.3 9.7e-08 32.5 0.3 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain RecA PF00154.21 EFE42113.1 - 0.00046 19.7 0.0 0.001 18.6 0.0 1.5 1 1 0 1 1 1 1 recA bacterial DNA recombination protein DnaB_bind PF10410.9 EFE42113.1 - 0.063 13.5 0.0 1.7 8.9 0.0 2.5 1 1 0 1 1 1 0 DnaB-helicase binding domain of primase AAA_25 PF13481.6 EFE42113.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain FlgM PF04316.13 EFE42113.1 - 0.18 12.2 0.7 14 6.1 0.1 3.3 3 1 0 3 3 3 0 Anti-sigma-28 factor, FlgM UDPGP PF01704.18 EFE42114.1 - 2e-57 194.7 0.0 2.5e-57 194.4 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 EFE42114.1 - 0.024 15.0 0.0 0.07 13.5 0.0 1.8 1 0 0 1 1 1 0 MobA-like NTP transferase domain Fer4_20 PF14691.6 EFE42114.1 - 0.06 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pro_isomerase PF00160.21 EFE42115.1 - 2.4e-20 73.4 0.0 9.9e-18 64.9 0.0 2.3 1 1 1 2 2 2 2 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EFE42115.1 - 5.1e-16 58.3 0.1 7.4e-15 54.5 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_S24e PF01282.19 EFE42117.1 - 1.5e-32 111.4 0.1 2.8e-32 110.5 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S24e ALAD PF00490.21 EFE42117.1 - 0.099 11.8 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Delta-aminolevulinic acid dehydratase Methyltransf_16 PF10294.9 EFE42118.1 - 6e-20 71.7 0.0 7.9e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EFE42118.1 - 5.1e-05 23.9 0.0 8.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFE42118.1 - 5.3e-05 22.8 0.0 6.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFE42118.1 - 0.004 16.7 0.0 0.0068 16.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EFE42118.1 - 0.004 17.9 0.0 0.0067 17.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EFE42118.1 - 0.0051 16.2 0.0 0.0085 15.5 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Met_10 PF02475.16 EFE42118.1 - 0.0056 16.5 0.0 0.0085 15.9 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.6 EFE42118.1 - 0.012 15.5 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.12 EFE42118.1 - 0.027 14.2 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_11 PF08241.12 EFE42118.1 - 0.048 14.3 0.0 0.086 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 EFE42118.1 - 0.056 13.6 0.0 0.088 12.9 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Cons_hypoth95 PF03602.15 EFE42118.1 - 0.21 11.2 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PCMT PF01135.19 EFE42118.1 - 0.22 11.2 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) adh_short PF00106.25 EFE42119.1 - 4.8e-21 75.1 0.3 6.5e-21 74.7 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE42119.1 - 1.6e-15 57.3 0.2 2.2e-15 56.9 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE42119.1 - 0.0024 17.8 0.1 0.0036 17.3 0.1 1.3 1 0 0 1 1 1 1 KR domain Pro-kuma_activ PF09286.11 EFE42120.1 - 3.1e-36 124.8 0.0 1.4e-35 122.7 0.0 2.1 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain DUF2306 PF10067.9 EFE42121.1 - 6.8e-12 45.8 10.3 6.8e-12 45.8 10.3 1.6 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) Glyco_tran_28_C PF04101.16 EFE42121.1 - 0.12 12.4 0.1 0.2 11.6 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain CSN8_PSD8_EIF3K PF10075.9 EFE42122.1 - 2.5e-20 72.9 0.0 5e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EFE42122.1 - 0.0068 15.8 0.0 0.0092 15.4 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP family WD40 PF00400.32 EFE42123.1 - 0.0037 18.1 0.0 2.7 9.0 0.0 3.4 2 0 0 2 2 2 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 EFE42123.1 - 0.064 13.3 0.0 17 5.5 0.0 3.4 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region VP40 PF07447.12 EFE42123.1 - 0.14 11.3 0.0 1.2 8.2 0.0 2.0 2 0 0 2 2 2 0 Matrix protein VP40 Vps51 PF08700.11 EFE42124.1 - 1.1e-24 86.3 0.0 2.2e-24 85.3 0.0 1.6 1 0 0 1 1 1 1 Vps51/Vps67 COG5 PF10392.9 EFE42124.1 - 0.0017 18.6 0.0 0.0031 17.7 0.0 1.4 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Dor1 PF04124.12 EFE42124.1 - 0.05 12.3 0.1 0.059 12.0 0.1 1.1 1 0 0 1 1 1 0 Dor1-like family RMI1_N PF08585.12 EFE42125.1 - 2.7e-64 216.9 0.0 3.1e-64 216.7 0.0 1.0 1 0 0 1 1 1 1 RecQ mediated genome instability protein TPR_17 PF13431.6 EFE42126.1 - 2.3e-20 71.4 15.1 0.069 13.6 0.0 12.5 13 1 0 13 13 12 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFE42126.1 - 4.6e-18 63.8 46.3 0.032 14.3 0.1 15.9 17 0 0 17 17 15 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFE42126.1 - 1.8e-15 56.3 28.6 0.12 13.2 0.0 14.9 12 4 5 17 17 14 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFE42126.1 - 3.6e-15 55.0 38.2 0.22 11.4 0.1 13.6 14 1 0 14 14 14 6 Tetratricopeptide repeat TPR_19 PF14559.6 EFE42126.1 - 1.1e-14 54.6 19.5 6.4e-05 23.4 0.1 10.2 7 3 3 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFE42126.1 - 2.8e-14 52.5 21.6 0.0078 15.9 0.0 9.2 9 0 0 9 9 9 4 TPR repeat TPR_12 PF13424.6 EFE42126.1 - 6.9e-13 48.7 36.9 0.053 13.8 0.2 12.4 9 3 3 13 13 13 4 Tetratricopeptide repeat TPR_16 PF13432.6 EFE42126.1 - 1.9e-10 41.2 44.0 0.0019 18.8 0.3 11.7 11 1 1 12 12 11 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFE42126.1 - 4e-10 39.1 33.0 2.2 8.7 0.0 12.2 14 0 0 14 14 11 4 Tetratricopeptide repeat TPR_9 PF13371.6 EFE42126.1 - 0.00097 19.2 4.7 11 6.2 0.1 5.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFE42126.1 - 0.032 14.9 30.2 0.94 10.3 0.2 12.0 15 0 0 15 15 12 0 Tetratricopeptide repeat ANAPC5 PF12862.7 EFE42126.1 - 0.038 14.0 2.8 0.94 9.6 0.0 4.3 4 1 0 4 4 4 0 Anaphase-promoting complex subunit 5 Coatomer_E PF04733.14 EFE42126.1 - 0.045 13.2 0.1 0.18 11.2 0.1 2.1 1 0 0 1 1 1 0 Coatomer epsilon subunit TPR_22 PF18833.1 EFE42126.1 - 0.071 13.2 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat ChAPs PF09295.10 EFE42126.1 - 0.072 12.1 4.0 22 3.9 0.1 4.9 5 1 0 6 6 6 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF3465 PF11948.8 EFE42126.1 - 0.084 12.8 0.0 0.87 9.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3465) TPR_7 PF13176.6 EFE42126.1 - 0.45 10.6 15.7 34 4.8 0.1 8.3 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFE42126.1 - 3.8 7.5 19.5 20 5.2 0.0 7.6 7 0 0 7 7 7 0 Tetratricopeptide repeat Glyco_hydro_5_C PF18564.1 EFE42127.1 - 5.1e-22 78.2 0.0 1.2e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 EFE42127.1 - 9.1e-08 31.9 4.0 7.6e-06 25.6 1.6 2.7 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 EFE42127.1 - 0.027 13.8 0.1 7.1 5.9 0.0 2.2 2 0 0 2 2 2 0 Beta-galactosidase Xpo1 PF08389.12 EFE42128.1 - 5.3e-08 33.1 12.1 1.3e-07 31.8 3.8 3.8 3 1 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.19 EFE42128.1 - 0.015 15.2 2.1 0.1 12.5 0.0 3.4 4 0 0 4 4 4 0 Importin-beta N-terminal domain GRIM-19 PF06212.12 EFE42129.1 - 9.8e-07 28.8 0.1 1.4e-06 28.3 0.1 1.3 1 1 0 1 1 1 1 GRIM-19 protein tRNA_m1G_MT PF01746.21 EFE42130.1 - 9.8e-23 80.9 4.0 1.8e-22 80.0 0.0 2.4 2 1 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase ApbA_C PF08546.11 EFE42130.1 - 0.072 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal Rsc14 PF08586.10 EFE42130.1 - 0.88 10.4 3.1 3.2 8.6 3.1 1.9 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit VID27 PF08553.10 EFE42131.1 - 2.7e-194 645.1 0.0 4e-194 644.5 0.0 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 EFE42131.1 - 2.8e-75 251.9 0.2 2.8e-75 251.9 0.2 3.3 3 1 1 4 4 4 1 VID27 N-terminal region VID27_PH PF17747.1 EFE42131.1 - 2.4e-47 159.7 0.7 1e-46 157.7 0.3 2.1 2 0 0 2 2 2 1 VID27 PH-like domain PTPRCAP PF15713.5 EFE42131.1 - 3.1 8.1 14.7 11 6.3 14.7 1.8 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Usp PF00582.26 EFE42131.1 - 9.1 6.8 6.1 65 4.0 0.1 2.7 2 0 0 2 2 2 0 Universal stress protein family TLD PF07534.16 EFE42132.1 - 2.6e-23 82.8 0.0 8.3e-15 55.2 0.0 2.4 2 0 0 2 2 2 2 TLD Adaptin_N PF01602.20 EFE42133.1 - 4.9e-130 434.6 2.9 5.7e-130 434.3 2.9 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFE42133.1 - 5.5e-65 218.3 1.4 1.2e-61 207.5 0.4 2.8 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFE42133.1 - 4.9e-17 62.1 4.4 6.3e-07 29.7 0.0 5.7 4 2 2 6 6 6 4 HEAT repeats HEAT PF02985.22 EFE42133.1 - 5.9e-13 47.9 0.3 0.016 15.4 0.0 6.3 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EFE42133.1 - 0.00074 20.0 5.3 0.7 10.5 0.0 6.0 7 1 1 8 8 8 1 HEAT-like repeat CLASP_N PF12348.8 EFE42133.1 - 0.0031 17.1 0.3 1.6 8.3 0.0 3.4 3 1 1 4 4 4 1 CLASP N terminal Arm PF00514.23 EFE42133.1 - 0.0097 15.9 5.0 9 6.5 0.0 5.9 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EFE42133.1 - 0.019 15.1 0.1 3.2 8.0 0.0 3.7 2 2 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Ribosomal_60s PF00428.19 EFE42133.1 - 2.4 8.8 8.6 12 6.5 4.8 3.4 3 0 0 3 3 3 0 60s Acidic ribosomal protein DEK_C PF08766.11 EFE42134.1 - 0.0072 16.2 0.1 0.023 14.6 0.1 1.8 1 0 0 1 1 1 1 DEK C terminal domain CDC27 PF09507.10 EFE42134.1 - 0.46 9.8 35.9 0.67 9.3 35.9 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Evr1_Alr PF04777.13 EFE42135.1 - 5.8e-29 100.5 3.7 1.2e-28 99.5 3.7 1.5 1 0 0 1 1 1 1 Erv1 / Alr family Coatomer_WDAD PF04053.14 EFE42136.1 - 3.9e-142 474.4 0.0 5.6e-142 473.9 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EFE42136.1 - 5.4e-103 344.9 0.6 5.6e-102 341.5 0.6 2.0 1 1 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EFE42136.1 - 2.7e-33 113.4 18.3 1.7e-07 31.8 0.3 7.0 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE42136.1 - 1.6e-06 28.3 0.1 0.021 15.1 0.0 5.0 4 2 4 8 8 8 1 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 EFE42136.1 - 0.0047 16.8 0.1 0.34 10.8 0.0 2.9 3 0 0 3 3 3 1 Region in Clathrin and VPS Nup160 PF11715.8 EFE42136.1 - 0.016 13.9 5.8 1.5 7.4 0.3 3.6 2 1 2 4 4 4 0 Nucleoporin Nup120/160 Phytase-like PF13449.6 EFE42138.1 - 1.4e-40 140.1 0.1 1.8e-40 139.7 0.1 1.2 1 0 0 1 1 1 1 Esterase-like activity of phytase SdiA-regulated PF06977.11 EFE42138.1 - 0.15 11.3 0.1 1.2 8.3 0.0 2.4 3 0 0 3 3 3 0 SdiA-regulated Clr5 PF14420.6 EFE42140.1 - 0.00023 21.3 0.4 0.00023 21.3 0.4 2.6 2 1 0 2 2 2 1 Clr5 domain MCM6_C PF18263.1 EFE42140.1 - 0.046 13.9 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 MCM6 C-terminal winged-helix domain Het-C PF07217.11 EFE42141.1 - 2.2e-244 812.2 0.0 3.1e-244 811.7 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C DUF2828 PF11443.8 EFE42142.1 - 5.7e-234 777.9 0.5 6.9e-234 777.6 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) FAD-oxidase_C PF02913.19 EFE42143.1 - 5.5e-52 176.9 0.2 9.8e-52 176.1 0.2 1.4 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFE42143.1 - 3.3e-35 120.9 0.0 5.6e-35 120.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Mannosidase_ig PF17786.1 EFE42144.1 - 4.8e-18 65.6 0.2 3.9e-16 59.4 0.0 2.5 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EFE42144.1 - 8.4e-13 49.0 0.0 2.8e-12 47.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 EFE42144.1 - 8.1e-06 25.2 0.6 4e-05 22.9 0.6 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 EFE42144.1 - 1.1e-05 25.4 0.1 3.3e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Ig_mannosidase PF17753.1 EFE42144.1 - 0.00068 19.3 0.0 0.0027 17.4 0.0 2.0 2 0 0 2 2 2 1 Ig-fold domain ADH_zinc_N PF00107.26 EFE42145.1 - 8.2e-25 87.3 0.1 1.5e-24 86.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFE42145.1 - 1.2e-07 31.4 0.2 3.1e-07 30.1 0.2 1.6 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EFE42145.1 - 5.1e-05 24.3 0.0 0.00011 23.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFE42145.1 - 0.00073 18.9 0.2 0.0011 18.3 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EFE42145.1 - 0.0035 17.0 0.1 0.0053 16.4 0.1 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FtsJ PF01728.19 EFE42145.1 - 0.0059 16.7 0.0 0.016 15.3 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 EFE42145.1 - 0.0081 16.9 0.0 0.014 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Pyr_redox_2 PF07992.14 EFE42145.1 - 0.022 14.0 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFE42145.1 - 0.04 12.6 0.2 0.059 12.1 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein PrmA PF06325.13 EFE42145.1 - 0.048 13.1 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EFE42145.1 - 0.049 13.4 0.0 0.068 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain KAR9 PF08580.10 EFE42147.1 - 1.9e-243 810.0 0.0 1.9e-243 810.0 0.0 2.8 2 2 1 3 3 3 1 Yeast cortical protein KAR9 CDC45 PF02724.14 EFE42148.1 - 0.016 13.5 9.2 0.022 13.1 9.2 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EFE42148.1 - 0.081 12.3 13.2 0.16 11.4 13.2 1.4 1 0 0 1 1 1 0 SDA1 Zip PF02535.22 EFE42148.1 - 0.93 8.6 2.0 1.2 8.3 2.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 EFE42148.1 - 1 9.8 4.4 2 8.9 4.4 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 ALMT PF11744.8 EFE42148.1 - 3.1 6.5 5.4 4.2 6.1 5.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Menin PF05053.13 EFE42148.1 - 4.5 5.5 7.7 7 4.9 7.7 1.3 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 EFE42148.1 - 5 7.7 16.3 0.14 12.7 9.0 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain NPR3 PF03666.13 EFE42148.1 - 6.2 5.5 9.4 9.2 4.9 9.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 EFE42148.1 - 8.3 5.1 8.8 11 4.6 8.8 1.1 1 0 0 1 1 1 0 Presenilin CRAL_TRIO PF00650.20 EFE42149.1 - 2.8e-36 124.6 0.0 4.3e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EFE42149.1 - 0.0046 17.1 0.0 0.0083 16.3 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF1769 PF08588.10 EFE42149.1 - 0.093 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) AOX PF01786.17 EFE42151.1 - 3.4e-98 327.5 0.0 3.9e-98 327.3 0.0 1.0 1 0 0 1 1 1 1 Alternative oxidase adh_short PF00106.25 EFE42152.1 - 7.2e-25 87.6 0.0 1e-24 87.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE42152.1 - 1.1e-19 71.0 0.0 1.5e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE42152.1 - 2.1e-05 24.5 0.0 2.8e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EFE42152.1 - 0.0089 15.4 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PALP PF00291.25 EFE42152.1 - 0.023 14.1 0.0 0.026 13.9 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Epimerase PF01370.21 EFE42152.1 - 0.055 12.9 0.0 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 EFE42152.1 - 0.088 12.7 0.1 0.16 11.8 0.1 1.6 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MBOAT PF03062.19 EFE42153.1 - 4e-45 154.7 14.6 2.7e-34 119.1 7.4 2.3 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family FA_desaturase PF00487.24 EFE42154.1 - 6.4e-29 101.5 22.9 9.7e-29 101.0 22.9 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFE42154.1 - 5.3e-08 32.9 0.0 9.9e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Dopey_N PF04118.14 EFE42155.1 - 3.3e-120 400.9 0.1 2.1e-119 398.2 0.0 2.3 3 0 0 3 3 3 1 Dopey, N-terminal Mon1 PF03164.14 EFE42156.1 - 1.3e-125 419.6 0.0 1.7e-125 419.3 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 HRDC PF00570.23 EFE42157.1 - 5.4e-09 35.9 0.0 8.7e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 HRDC domain Paf1 PF03985.13 EFE42159.1 - 1 8.3 5.9 1 8.3 5.9 1.0 1 0 0 1 1 1 0 Paf1 N_BRCA1_IG PF16158.5 EFE42160.1 - 5.1e-32 110.6 0.0 1.2e-31 109.4 0.0 1.7 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 EFE42160.1 - 8.6e-15 54.3 37.7 1.2e-06 28.2 8.9 3.5 3 0 0 3 3 3 3 Zinc finger, ZZ type LETM1 PF07766.13 EFE42161.1 - 4.3e-10 39.4 0.5 9.7e-06 25.1 0.2 2.3 1 1 1 2 2 2 2 LETM1-like protein Glyco_hydro_44 PF12891.7 EFE42162.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase family 44 NTP_transf_2 PF01909.23 EFE42162.1 - 0.15 12.4 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain Glyco_transf_20 PF00982.21 EFE42163.1 - 5.2e-149 496.9 0.0 8.3e-149 496.3 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EFE42163.1 - 1e-82 276.8 0.0 2e-82 275.8 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase Acetyltransf_1 PF00583.25 EFE42164.1 - 6.3e-13 49.0 0.0 8.7e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFE42164.1 - 2.2e-09 37.6 0.0 4.2e-09 36.7 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFE42164.1 - 6.3e-08 32.6 0.0 1.2e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE42164.1 - 3.3e-06 27.0 0.0 5.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFE42164.1 - 0.00061 19.9 0.0 0.0011 19.1 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase PanZ PF12568.8 EFE42164.1 - 0.067 12.9 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_3 PF13302.7 EFE42164.1 - 0.086 13.5 0.0 0.16 12.6 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.16 EFE42165.1 - 2.4e-17 62.9 51.1 6.7e-17 61.4 41.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RepA1_leader PF08048.12 EFE42166.1 - 0.25 11.6 3.8 6 7.2 1.9 2.2 2 0 0 2 2 2 0 Tap RepA1 leader peptide PP28 PF10252.9 EFE42167.1 - 1.6e-28 98.9 19.0 1.6e-28 98.9 19.0 3.9 2 2 1 3 3 3 1 Casein kinase substrate phosphoprotein PP28 CENP-B_dimeris PF09026.10 EFE42167.1 - 5 7.6 23.4 15 6.1 13.1 3.2 3 0 0 3 3 3 0 Centromere protein B dimerisation domain MFS_1 PF07690.16 EFE42168.1 - 4.7e-34 117.9 27.1 1.5e-33 116.3 27.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EFE42168.1 - 0.0026 17.1 21.8 0.44 9.8 21.8 2.2 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Holin_BhlA PF10960.8 EFE42168.1 - 0.045 13.7 0.1 0.13 12.2 0.0 1.8 2 0 0 2 2 2 0 BhlA holin family PMP22_Claudin PF00822.20 EFE42169.1 - 0.14 12.0 2.7 0.19 11.6 0.7 2.1 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin family FAD_binding_3 PF01494.19 EFE42170.1 - 1.2e-15 57.6 0.0 3.9e-09 36.2 0.0 3.0 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EFE42170.1 - 5.5e-07 29.7 0.1 1.3e-06 28.5 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE42170.1 - 2.3e-06 27.1 0.0 0.0027 17.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE42170.1 - 1.2e-05 25.7 0.0 0.00079 19.9 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFE42170.1 - 8.5e-05 22.3 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase PQQ PF01011.21 EFE42170.1 - 0.0087 15.9 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 PQQ enzyme repeat FAD_binding_2 PF00890.24 EFE42170.1 - 0.01 15.0 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFE42170.1 - 0.18 10.5 0.1 0.5 9.0 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.12 EFE42170.1 - 0.21 10.6 0.1 0.43 9.6 0.0 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein COesterase PF00135.28 EFE42172.1 - 8.9e-70 236.0 0.0 1.4e-69 235.4 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE42172.1 - 0.11 12.3 0.1 0.53 10.1 0.1 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold Sec7 PF01369.20 EFE42174.1 - 3.4e-27 95.3 0.0 6.3e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EFE42174.1 - 2.9e-19 69.6 0.5 7.2e-19 68.3 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Mto2_bdg PF12808.7 EFE42175.1 - 1.8e-29 101.8 32.4 1.8e-19 69.8 20.1 10.1 11 1 1 12 12 12 2 Micro-tubular organiser Mto1 C-term Mto2-binding region Cnn_1N PF07989.11 EFE42175.1 - 2.3e-22 78.9 9.5 2.3e-22 78.9 9.5 11.8 8 2 3 11 11 11 2 Centrosomin N-terminal motif 1 Fib_alpha PF08702.10 EFE42175.1 - 0.0018 18.4 8.5 0.0018 18.4 8.5 8.0 4 1 4 8 8 8 2 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EFE42175.1 - 0.23 11.5 0.1 0.23 11.5 0.1 7.8 4 1 2 8 8 8 0 Protein of unknown function (DUF1664) DUF2935 PF11155.8 EFE42175.1 - 0.81 10.0 9.6 6.6 7.1 0.4 5.7 3 1 2 5 5 5 0 Domain of unknown function (DUF2935) QRPTase_C PF01729.19 EFE42176.1 - 2.3e-48 164.2 0.8 1.5e-45 155.0 0.8 2.0 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EFE42176.1 - 1.5e-11 44.2 0.0 6.3e-11 42.2 0.0 2.0 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain LysR_substrate PF03466.20 EFE42176.1 - 0.12 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 LysR substrate binding domain DUF768 PF05589.11 EFE42176.1 - 0.2 11.7 3.4 2.1 8.4 0.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF768) Glyoxalase_6 PF18029.1 EFE42177.1 - 3.9e-07 30.8 0.0 5.5e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 EFE42177.1 - 6.4e-05 23.1 0.0 0.00017 21.8 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFE42177.1 - 0.067 13.5 0.0 0.56 10.5 0.0 2.0 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EFE42177.1 - 0.092 12.7 0.0 0.25 11.3 0.0 1.6 1 1 0 1 1 1 0 Glyoxalase-like domain Aldose_epim PF01263.20 EFE42178.1 - 2.1e-57 194.8 0.0 2.3e-57 194.6 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Zn_clus PF00172.18 EFE42179.1 - 7.4e-09 35.6 10.7 1.1e-08 35.1 10.7 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NOA36 PF06524.12 EFE42180.1 - 0.5 9.6 8.2 0.6 9.4 8.2 1.1 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EFE42180.1 - 0.58 10.6 12.7 0.82 10.1 12.7 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Nop14 PF04147.12 EFE42180.1 - 0.78 7.9 2.0 0.85 7.7 2.0 1.0 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 EFE42180.1 - 2.8 7.0 10.2 3.3 6.7 10.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 EFE42180.1 - 4.9 5.1 9.7 6 4.8 9.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi Ras PF00071.22 EFE42181.1 - 1.5e-12 47.4 0.0 7.5e-06 25.6 0.0 2.1 2 0 0 2 2 2 2 Ras family Peptidase_S41 PF03572.18 EFE42182.1 - 1.8e-07 30.9 0.0 3.9e-07 29.8 0.0 1.5 1 1 0 1 1 1 1 Peptidase family S41 HemY_N PF07219.13 EFE42183.1 - 5.5 7.2 5.7 13 6.1 0.2 2.3 2 0 0 2 2 2 0 HemY protein N-terminus GRAB PF10375.9 EFE42185.1 - 5.5e-08 32.4 0.2 1.2e-07 31.4 0.2 1.6 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Golgin_A5 PF09787.9 EFE42185.1 - 0.0027 17.2 55.2 0.3 10.5 22.2 3.3 1 1 2 3 3 3 3 Golgin subfamily A member 5 Fez1 PF06818.15 EFE42185.1 - 0.0057 17.1 49.1 0.024 15.1 7.4 3.3 2 1 1 3 3 3 2 Fez1 Baculo_PEP_C PF04513.12 EFE42185.1 - 0.0071 16.4 13.3 0.91 9.6 6.3 3.1 2 1 1 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus APC_N_CC PF16689.5 EFE42185.1 - 0.011 15.8 3.1 0.011 15.8 3.1 4.0 4 0 0 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain FAM184 PF15665.5 EFE42185.1 - 0.072 12.9 47.4 0.083 12.7 11.4 3.2 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B DUF812 PF05667.11 EFE42185.1 - 0.44 9.4 51.6 0.014 14.3 32.6 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF812) FliJ PF02050.16 EFE42185.1 - 0.69 10.2 43.9 0.064 13.5 15.8 3.7 1 1 2 3 3 3 0 Flagellar FliJ protein HALZ PF02183.18 EFE42185.1 - 0.84 9.9 17.3 5.5 7.3 0.0 6.0 4 1 2 6 6 6 0 Homeobox associated leucine zipper Spc7 PF08317.11 EFE42185.1 - 1.7 7.5 51.9 3.5 6.4 29.6 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF641 PF04859.12 EFE42185.1 - 4.2 7.7 37.2 1.5 9.2 4.7 4.7 2 1 3 5 5 5 0 Plant protein of unknown function (DUF641) DUF3584 PF12128.8 EFE42185.1 - 4.5 4.7 47.7 3.4 5.0 32.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Filament PF00038.21 EFE42185.1 - 5.1 6.6 49.0 47 3.4 26.4 3.3 1 1 1 2 2 2 0 Intermediate filament protein NPV_P10 PF05531.12 EFE42185.1 - 6.2 7.4 12.6 14 6.2 0.5 4.5 2 2 3 5 5 5 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 EFE42185.1 - 6.3 7.0 27.7 0.76 10.0 2.0 3.5 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family GAS PF13851.6 EFE42185.1 - 8.3 5.7 51.6 1.2 8.4 9.7 3.4 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Guanylate_kin PF00625.21 EFE42186.1 - 3.7e-45 153.9 0.0 4.6e-45 153.5 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase DUF3774 PF12609.8 EFE42186.1 - 0.13 13.3 0.0 0.2 12.7 0.0 1.4 1 1 0 1 1 1 0 Wound-induced protein Septin PF00735.18 EFE42187.1 - 1.3e-112 375.7 0.6 1.6e-112 375.4 0.6 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EFE42187.1 - 7.6e-08 32.4 0.0 1.7e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFE42187.1 - 5e-06 26.0 0.0 8.5e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EFE42187.1 - 5.9e-05 23.0 0.5 0.00027 20.9 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EFE42187.1 - 0.00036 20.1 0.8 0.016 14.8 0.1 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFE42187.1 - 0.00052 20.1 0.3 1.5 8.9 0.0 2.5 1 1 0 2 2 2 2 Dynamin family NB-ARC PF00931.22 EFE42187.1 - 0.0034 16.6 0.1 0.0058 15.8 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EFE42187.1 - 0.0047 17.3 0.0 0.012 16.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 EFE42187.1 - 0.0059 16.1 0.1 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFE42187.1 - 0.009 16.3 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFE42187.1 - 0.014 15.9 0.2 0.034 14.7 0.2 1.6 1 1 0 1 1 1 0 ABC transporter G-alpha PF00503.20 EFE42187.1 - 0.048 12.8 0.5 0.4 9.8 0.1 1.9 1 1 1 2 2 2 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 EFE42187.1 - 0.087 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Gtr1_RagA PF04670.12 EFE42187.1 - 0.088 12.1 0.0 0.65 9.3 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 EFE42187.1 - 0.09 12.5 0.3 0.41 10.4 0.0 2.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain T2SSE PF00437.20 EFE42187.1 - 0.11 11.5 0.0 0.3 10.1 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 EFE42187.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ribosomal_L32p PF01783.23 EFE42188.1 - 6.8e-14 51.9 7.3 9.9e-14 51.3 7.3 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family zinc-ribbons_6 PF07191.12 EFE42188.1 - 0.04 13.9 0.5 0.056 13.4 0.5 1.2 1 0 0 1 1 1 0 zinc-ribbons CpXC PF14353.6 EFE42188.1 - 0.15 12.1 1.1 1 9.4 1.2 2.0 1 1 0 1 1 1 0 CpXC protein zf-ribbon_3 PF13248.6 EFE42188.1 - 0.17 11.3 5.1 0.33 10.4 5.1 1.5 1 1 0 1 1 1 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 EFE42188.1 - 2.3 8.3 6.0 3.2 7.8 0.4 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain WD40 PF00400.32 EFE42189.1 - 3.2e-20 72.1 4.8 1.5e-08 35.1 0.3 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE42189.1 - 7.9e-11 42.1 1.6 0.00033 20.9 0.4 3.2 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE42189.1 - 0.0012 17.6 0.1 0.67 8.5 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EFE42189.1 - 0.005 16.7 0.1 0.08 12.8 0.0 2.5 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 EFE42189.1 - 0.13 12.0 0.2 3.8 7.2 0.0 2.2 2 0 0 2 2 2 0 TUP1-like enhancer of split Nucleoporin_N PF08801.11 EFE42189.1 - 0.18 10.5 0.2 0.63 8.7 0.0 1.9 2 1 0 2 2 2 0 Nup133 N terminal like Spindle_Spc25 PF08234.12 EFE42190.1 - 2.9e-24 85.1 0.1 1.1e-23 83.1 0.0 2.1 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 ERM PF00769.19 EFE42190.1 - 0.8 9.5 20.8 1.2 8.9 20.8 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family V_ATPase_I PF01496.19 EFE42190.1 - 0.87 7.4 5.9 0.96 7.3 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF334 PF03904.13 EFE42190.1 - 2 7.9 10.5 2.8 7.4 10.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) Ku_C PF03730.14 EFE42190.1 - 2.8 8.7 7.3 1.3 9.7 3.8 2.0 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm Calpain_III PF01067.22 EFE42190.1 - 3.4 7.9 5.9 5.2 7.3 5.9 1.2 1 0 0 1 1 1 0 Calpain large subunit, domain III Exonuc_VII_L PF02601.15 EFE42190.1 - 3.7 7.0 10.7 5.1 6.6 10.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.12 EFE42190.1 - 5.3 5.5 6.1 6.5 5.2 6.1 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family LMBR1 PF04791.16 EFE42190.1 - 7.6 5.3 5.7 8.4 5.2 5.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 EFE42190.1 - 7.6 5.8 12.1 11 5.3 12.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Rrn6 PF10214.9 EFE42191.1 - 7.8e-216 719.4 1.2 8.9e-216 719.3 1.2 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor zinc_ribbon_6 PF14599.6 EFE42192.1 - 5.3e-19 68.0 0.1 8.4e-19 67.3 0.1 1.2 1 0 0 1 1 1 1 Zinc-ribbon NOA36 PF06524.12 EFE42192.1 - 0.15 11.4 2.7 0.19 11.0 2.7 1.2 1 0 0 1 1 1 0 NOA36 protein MFMR_assoc PF16596.5 EFE42192.1 - 0.73 10.3 8.0 0.21 12.1 4.6 1.8 2 1 0 2 2 2 0 Disordered region downstream of MFMR Astro_capsid_p PF12226.8 EFE42192.1 - 2.7 7.1 5.2 3.7 6.6 5.2 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CENP-B_dimeris PF09026.10 EFE42192.1 - 5.9 7.3 12.2 11 6.5 12.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GAS PF13851.6 EFE42194.1 - 0.00025 20.5 15.8 0.023 14.1 3.0 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Phlebovirus_NSM PF07246.11 EFE42194.1 - 0.0015 17.9 4.0 0.0027 17.1 4.0 1.4 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M CENP-F_leu_zip PF10473.9 EFE42194.1 - 0.002 18.1 19.0 0.0021 18.1 1.5 3.3 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PRKG1_interact PF15898.5 EFE42194.1 - 0.0033 18.3 9.2 0.0033 18.3 9.2 3.3 3 1 0 3 3 3 1 cGMP-dependent protein kinase interacting domain WES_acyltransf PF03007.16 EFE42194.1 - 0.007 16.2 2.1 0.0095 15.7 1.3 1.6 1 1 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain TMCO5 PF14992.6 EFE42194.1 - 0.033 13.8 11.7 0.066 12.8 11.7 1.5 1 0 0 1 1 1 0 TMCO5 family bZIP_1 PF00170.21 EFE42194.1 - 0.036 14.2 0.4 0.036 14.2 0.4 3.2 2 1 0 3 3 3 0 bZIP transcription factor ZapB PF06005.12 EFE42194.1 - 0.036 14.5 2.1 0.036 14.5 2.1 3.2 1 1 1 2 2 2 0 Cell division protein ZapB PI3K_P85_iSH2 PF16454.5 EFE42194.1 - 0.037 13.6 11.6 0.15 11.7 11.6 2.1 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain HMMR_C PF15908.5 EFE42194.1 - 0.08 13.2 6.5 0.17 12.1 6.5 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal DUF4530 PF15039.6 EFE42194.1 - 0.1 12.8 0.1 0.23 11.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) DUF2968 PF11180.8 EFE42194.1 - 0.1 12.2 12.9 0.39 10.3 5.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) HALZ PF02183.18 EFE42194.1 - 0.1 12.9 1.7 1.3 9.3 0.1 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper FlaC_arch PF05377.11 EFE42194.1 - 0.1 13.0 9.1 3.9 7.9 0.2 3.6 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 EFE42194.1 - 0.13 12.1 9.4 0.19 11.5 0.2 3.1 1 1 2 3 3 3 0 Septum formation initiator ATPase PF06745.13 EFE42194.1 - 0.63 9.3 5.2 1.1 8.5 4.4 1.8 1 1 0 2 2 2 0 KaiC DUF3450 PF11932.8 EFE42194.1 - 0.68 9.2 9.7 1.3 8.3 8.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Fez1 PF06818.15 EFE42194.1 - 0.79 10.1 16.0 0.86 10.0 14.5 1.7 1 1 0 1 1 1 0 Fez1 FUSC PF04632.12 EFE42194.1 - 0.91 8.0 5.7 1.2 7.5 5.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TolA_bind_tri PF16331.5 EFE42194.1 - 0.99 9.5 16.2 0.4 10.8 0.4 3.4 2 1 1 3 3 3 0 TolA binding protein trimerisation bZIP_Maf PF03131.17 EFE42194.1 - 3.1 8.4 12.6 6.6 7.3 0.2 3.3 2 1 1 3 3 3 0 bZIP Maf transcription factor DUF724 PF05266.14 EFE42194.1 - 4 7.2 16.5 1.8 8.3 11.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) ALMT PF11744.8 EFE42194.1 - 4.3 6.1 13.3 7 5.4 13.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter IFP_35_N PF07334.13 EFE42194.1 - 4.9 7.3 7.8 4.3 7.5 0.0 3.7 3 1 1 4 4 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF4094 PF13334.6 EFE42194.1 - 6.2 7.3 15.3 0.31 11.5 0.9 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) APG6_N PF17675.1 EFE42194.1 - 9.4 6.8 15.8 52 4.4 14.6 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region OST3_OST6 PF04756.13 EFE42195.1 - 1e-90 304.0 0.0 1.4e-90 303.6 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family HXXEE PF13787.6 EFE42195.1 - 0.01 16.6 0.5 0.01 16.6 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif MerC PF03203.14 EFE42195.1 - 0.84 10.1 7.5 11 6.5 2.1 3.1 3 0 0 3 3 3 0 MerC mercury resistance protein HABP4_PAI-RBP1 PF04774.15 EFE42196.1 - 0.0056 17.5 2.8 0.0079 17.0 2.8 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family Nucleoporin_C PF03177.14 EFE42197.1 - 1e-169 566.1 9.3 1.2e-169 565.9 9.3 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 EFE42197.1 - 2.6e-53 181.4 0.0 3.7e-53 180.8 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like NIR_SIR PF01077.22 EFE42197.1 - 0.032 13.8 0.0 0.2 11.2 0.0 2.2 2 0 0 2 2 2 0 Nitrite and sulphite reductase 4Fe-4S domain DWNN PF08783.11 EFE42198.1 - 1.3e-33 115.0 0.1 3.1e-33 113.9 0.1 1.7 1 0 0 1 1 1 1 DWNN domain zf-RING_2 PF13639.6 EFE42198.1 - 0.04 14.3 6.2 0.072 13.4 6.2 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EFE42198.1 - 0.051 13.4 8.9 0.091 12.6 8.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-CCHC_2 PF13696.6 EFE42198.1 - 0.068 13.0 1.2 0.086 12.7 0.3 1.6 2 0 0 2 2 2 0 Zinc knuckle DUF1272 PF06906.11 EFE42198.1 - 0.16 12.0 4.7 0.32 11.1 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) CDC45 PF02724.14 EFE42198.1 - 0.16 10.2 4.6 0.29 9.4 4.6 1.3 1 0 0 1 1 1 0 CDC45-like protein FYVE_2 PF02318.16 EFE42198.1 - 0.18 12.1 1.8 0.37 11.0 1.8 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger zf-RING_4 PF14570.6 EFE42198.1 - 0.32 10.8 5.8 0.64 9.9 5.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 EFE42198.1 - 0.41 10.6 5.4 0.81 9.7 5.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EFE42198.1 - 2.3 8.2 8.0 4.4 7.3 8.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFE42198.1 - 2.6 8.3 8.2 6.1 7.1 8.2 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Med14 PF08638.11 EFE42199.1 - 3.9e-52 176.5 0.0 6.8e-52 175.7 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 Thioredoxin PF00085.20 EFE42200.1 - 2.9e-68 226.3 7.5 1e-31 109.0 0.1 4.3 4 0 0 4 4 4 4 Thioredoxin Thioredoxin_6 PF13848.6 EFE42200.1 - 8.2e-54 182.3 4.6 8.3e-39 133.4 1.2 3.4 2 1 1 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 EFE42200.1 - 5.5e-09 35.8 1.2 0.00048 19.6 0.0 3.4 2 1 2 4 4 4 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EFE42200.1 - 1.4e-08 35.0 0.1 0.069 13.5 0.0 4.9 4 1 1 5 5 5 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EFE42200.1 - 3e-08 34.1 4.3 0.0021 18.5 0.1 4.2 2 2 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EFE42200.1 - 9.7e-08 32.1 0.0 0.011 15.9 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 EFE42200.1 - 3.3e-07 30.3 0.1 0.003 17.5 0.1 2.9 3 0 0 3 3 3 2 AhpC/TSA family Calsequestrin PF01216.17 EFE42200.1 - 1.3e-06 27.7 0.7 1.3e-06 27.7 0.7 2.0 1 1 1 2 2 2 1 Calsequestrin Redoxin PF08534.10 EFE42200.1 - 0.00036 20.3 1.1 0.57 9.9 0.0 3.0 3 0 0 3 3 3 2 Redoxin Thioredoxin_3 PF13192.6 EFE42200.1 - 0.011 15.8 0.3 0.052 13.6 0.1 2.3 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_4 PF13462.6 EFE42200.1 - 0.3 11.2 2.5 14 5.8 0.0 3.4 3 0 0 3 3 3 0 Thioredoxin Yippee-Mis18 PF03226.14 EFE42201.1 - 6.6e-15 55.2 0.0 8.4e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SHNi-TPR PF10516.9 EFE42202.1 - 1.8e-16 59.2 2.8 4.8e-14 51.5 0.3 2.6 2 0 0 2 2 2 2 SHNi-TPR TPR_12 PF13424.6 EFE42202.1 - 4.5e-07 30.1 6.0 0.0015 18.7 0.9 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 EFE42202.1 - 0.027 14.5 2.5 0.027 14.5 2.5 2.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain XhlA PF10779.9 EFE42202.1 - 1.6 9.0 6.6 9.2 6.6 0.6 2.8 2 0 0 2 2 2 0 Haemolysin XhlA GCIP PF13324.6 EFE42202.1 - 2 7.9 9.9 0.67 9.5 2.5 2.4 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting TPR_3 PF07720.12 EFE42202.1 - 3 7.9 7.7 0.59 10.2 0.7 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DNA_pol_E_B PF04042.16 EFE42203.1 - 4.9e-49 166.5 0.0 8.5e-49 165.8 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B His_biosynth PF00977.21 EFE42204.1 - 3e-44 151.2 1.0 1e-43 149.4 1.0 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 EFE42204.1 - 8.5e-26 90.9 0.0 1.4e-25 90.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 EFE42204.1 - 5.3e-12 46.0 0.0 2.1e-11 44.0 0.0 1.9 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EFE42204.1 - 6.3e-10 39.0 0.0 1.4e-09 37.9 0.0 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 EFE42204.1 - 0.0019 18.0 0.1 0.027 14.3 0.0 2.2 2 0 0 2 2 2 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 EFE42204.1 - 0.0089 15.7 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S51 dCMP_cyt_deam_1 PF00383.23 EFE42205.1 - 2.3e-18 65.9 0.1 4.3e-18 65.0 0.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFE42205.1 - 3.9e-07 29.9 0.0 8.4e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 MafB19-like deaminase MGAT2 PF05060.14 EFE42205.1 - 0.11 11.5 0.1 0.15 11.0 0.1 1.1 1 0 0 1 1 1 0 N-acetylglucosaminyltransferase II (MGAT2) ATG7_N PF16420.5 EFE42206.1 - 1.8e-93 313.5 0.0 8.4e-59 199.7 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EFE42206.1 - 1.3e-41 142.6 0.0 1.8e-41 142.1 0.0 1.1 1 0 0 1 1 1 1 ThiF family ApbA PF02558.16 EFE42206.1 - 0.013 15.2 0.0 0.09 12.4 0.0 2.3 2 1 1 3 3 3 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EFE42206.1 - 0.029 14.4 0.0 0.067 13.3 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFE42206.1 - 0.079 12.3 0.0 0.25 10.7 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UCH PF00443.29 EFE42207.1 - 1e-36 126.8 0.0 1.4e-36 126.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EFE42207.1 - 1.1e-19 70.5 1.4 1.1e-19 70.5 1.4 2.2 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EFE42207.1 - 8.2e-16 58.5 0.0 2.6e-13 50.3 0.0 3.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 EFE42207.1 - 8.5e-15 54.3 0.1 2.2e-07 30.6 0.0 2.7 3 0 0 3 3 3 2 UBA/TS-N domain UBA_4 PF14555.6 EFE42207.1 - 0.0076 16.1 0.0 0.017 14.9 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain DUF3795 PF12675.7 EFE42207.1 - 5.5 7.5 12.4 10 6.6 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3795) UDG PF03167.19 EFE42209.1 - 3.3e-22 79.1 0.1 6.5e-22 78.2 0.1 1.5 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily FAM176 PF14851.6 EFE42209.1 - 1.4 8.6 11.7 0.049 13.3 3.8 2.2 2 0 0 2 2 2 0 FAM176 family NifU_N PF01592.16 EFE42210.1 - 6.2e-44 149.2 0.1 7.7e-44 148.9 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 EFE42210.1 - 0.015 15.6 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 TSCPD domain PCI PF01399.27 EFE42211.1 - 5.9e-05 23.5 0.3 0.00019 21.9 0.0 1.9 2 0 0 2 2 2 1 PCI domain Aldedh PF00171.22 EFE42212.1 - 2.9e-07 29.4 5.7 8.1e-06 24.6 0.2 3.0 3 0 0 3 3 3 3 Aldehyde dehydrogenase family DUF1487 PF07368.11 EFE42212.1 - 0.027 13.9 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Ribosomal_L18 PF17135.4 EFE42213.1 - 7.8e-95 315.6 2.1 8.6e-95 315.5 2.1 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EFE42213.1 - 1.1e-05 26.2 0.1 6.9e-05 23.5 0.1 2.2 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A AAA_19 PF13245.6 EFE42213.1 - 0.048 14.0 0.0 0.066 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sedlin_N PF04628.13 EFE42214.1 - 1.9e-15 57.2 0.0 3.7e-15 56.2 0.0 1.5 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region sCache_3_2 PF17203.4 EFE42214.1 - 0.079 13.1 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Single cache domain 3 RRM_1 PF00076.22 EFE42215.1 - 0.00018 21.3 0.1 0.00028 20.7 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mito_carr PF00153.27 EFE42216.1 - 1.1e-62 207.9 4.7 4e-21 74.7 0.0 3.8 3 2 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFE42216.1 - 0.0023 17.1 0.6 0.14 11.3 0.0 3.0 3 1 1 4 4 4 2 Gammaproteobacterial serine protease PXA PF02194.15 EFE42217.1 - 4.5e-33 114.8 0.0 1.2e-32 113.4 0.0 1.7 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EFE42217.1 - 1.1e-21 77.5 0.0 2.9e-21 76.1 0.0 1.8 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EFE42217.1 - 1.2e-09 38.1 0.0 3e-09 36.9 0.0 1.7 1 0 0 1 1 1 1 PX domain MBDa PF16564.5 EFE42217.1 - 0.072 13.3 0.2 0.4 10.9 0.2 2.1 2 0 0 2 2 2 0 p55-binding region of Methyl-CpG-binding domain proteins MBD PRELI PF04707.14 EFE42218.1 - 6.4e-45 152.8 0.3 7.4e-45 152.6 0.3 1.0 1 0 0 1 1 1 1 PRELI-like family CTP_transf_like PF01467.26 EFE42220.1 - 3.1e-18 66.3 0.0 1.2e-14 54.7 0.0 3.8 3 1 0 4 4 4 2 Cytidylyltransferase-like CCDC23 PF15674.5 EFE42221.1 - 0.53 10.3 13.6 0.32 11.0 6.6 2.6 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 23 DUF1216 PF06746.11 EFE42221.1 - 8.4 6.4 11.1 1.9 8.5 3.7 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1216) Glutaredoxin PF00462.24 EFE42222.1 - 5.6e-15 55.3 0.0 9.9e-15 54.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Flavoprotein PF02441.19 EFE42223.1 - 1.2e-43 148.6 0.0 1.7e-43 148.1 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein UbiA PF01040.18 EFE42224.1 - 1.5e-42 145.6 19.0 2e-42 145.3 19.0 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family JmjC PF02373.22 EFE42225.1 - 2.4e-08 34.4 0.8 6.5e-07 29.8 0.8 2.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 EFE42225.1 - 3.1e-06 27.3 8.0 3.1e-06 27.3 8.0 2.7 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.11 EFE42225.1 - 0.0093 15.7 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain zinc_ribbon_15 PF17032.5 EFE42225.1 - 1.2 9.9 14.8 1.4 9.7 2.1 3.4 3 0 0 3 3 3 0 zinc-ribbon family Coa1 PF08695.10 EFE42226.1 - 8.8e-44 148.0 0.0 1.1e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Ribosomal_L3 PF00297.22 EFE42227.1 - 2.8e-16 59.5 4.0 2.1e-14 53.3 0.5 2.1 1 1 1 2 2 2 2 Ribosomal protein L3 DUF1279 PF06916.13 EFE42228.1 - 1.1e-24 86.7 0.1 2.9e-24 85.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) Thioredoxin PF00085.20 EFE42230.1 - 8.9e-27 93.1 0.0 1e-26 92.9 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFE42230.1 - 5.9e-06 26.7 0.2 3.2e-05 24.3 0.2 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFE42230.1 - 1.7e-05 25.0 0.0 0.00022 21.5 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EFE42230.1 - 0.00036 20.3 0.0 0.00045 20.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EFE42230.1 - 0.00037 19.9 0.0 0.00043 19.7 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 EFE42230.1 - 0.0012 19.0 0.3 0.0017 18.6 0.3 1.2 1 0 0 1 1 1 1 Glutaredoxin TraF PF13728.6 EFE42230.1 - 0.0026 17.6 0.0 0.0031 17.4 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Redoxin PF08534.10 EFE42230.1 - 0.0057 16.4 0.3 0.026 14.2 0.3 1.8 1 1 1 2 2 2 1 Redoxin AhpC-TSA PF00578.21 EFE42230.1 - 0.0089 15.9 0.1 0.043 13.7 0.0 1.8 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_5 PF13743.6 EFE42230.1 - 0.041 13.6 0.0 0.25 11.0 0.0 1.8 1 1 1 2 2 2 0 Thioredoxin Thioredoxin_7 PF13899.6 EFE42230.1 - 0.051 13.7 0.5 0.088 13.0 0.5 1.5 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_3 PF13192.6 EFE42230.1 - 0.083 13.0 0.1 0.1 12.7 0.1 1.1 1 0 0 1 1 1 0 Thioredoxin domain DUF953 PF06110.11 EFE42230.1 - 0.092 12.4 0.5 0.33 10.6 0.5 1.8 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) HyaE PF07449.11 EFE42230.1 - 0.15 12.1 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE AA_permease_2 PF13520.6 EFE42232.1 - 0.024 13.5 0.8 0.031 13.1 0.8 1.1 1 0 0 1 1 1 0 Amino acid permease SR-25 PF10500.9 EFE42232.1 - 0.64 9.6 19.9 0.96 9.0 19.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4131 PF13567.6 EFE42232.1 - 9.1 5.9 6.7 3.6 7.2 1.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF1681 PF07933.14 EFE42233.1 - 7e-51 171.8 0.0 1.3e-50 170.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) FAM176 PF14851.6 EFE42233.1 - 0.0075 15.9 8.5 0.69 9.6 0.5 3.0 3 0 0 3 3 3 2 FAM176 family CPSF100_C PF13299.6 EFE42233.1 - 0.011 15.9 6.5 0.76 9.9 0.1 2.7 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Peptidase_S41 PF03572.18 EFE42233.1 - 0.18 11.4 0.1 0.55 9.8 0.0 1.8 2 0 0 2 2 2 0 Peptidase family S41 AIM3 PF17096.5 EFE42233.1 - 0.22 12.5 12.9 0.41 11.6 1.0 2.6 3 0 0 3 3 2 0 Altered inheritance of mitochondria protein 3 LEA_3 PF03242.13 EFE42233.1 - 0.44 11.3 7.4 0.33 11.7 1.6 2.8 2 1 1 3 3 2 0 Late embryogenesis abundant protein RXT2_N PF08595.11 EFE42233.1 - 0.46 10.5 7.5 2 8.4 0.1 2.6 3 0 0 3 3 3 0 RXT2-like, N-terminal Peptidase_S49_N PF08496.10 EFE42233.1 - 0.46 10.5 6.8 1.7 8.7 1.7 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Rxt3 PF08642.10 EFE42233.1 - 0.68 10.7 4.3 1.9 9.3 0.1 2.4 3 0 0 3 3 2 0 Histone deacetylation protein Rxt3 TFIIE-A_C PF11521.8 EFE42233.1 - 1.1 9.6 18.5 0.76 10.1 0.8 3.3 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha RNA_polI_A34 PF08208.11 EFE42233.1 - 1.2 9.2 21.3 2.1 8.4 2.1 2.9 3 0 0 3 3 3 0 DNA-directed RNA polymerase I subunit RPA34.5 Coilin_N PF15862.5 EFE42233.1 - 1.3 8.8 15.7 2.8 7.8 6.8 2.4 2 0 0 2 2 2 0 Coilin N-terminus Connexin PF00029.19 EFE42233.1 - 1.9 8.2 3.1 10 5.8 0.3 2.2 2 0 0 2 2 2 0 Connexin U1snRNP70_N PF12220.8 EFE42233.1 - 2 9.1 16.8 1 10.1 0.4 3.1 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal CMS1 PF14617.6 EFE42233.1 - 2.1 7.6 8.3 0.24 10.7 2.6 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit CDC45 PF02724.14 EFE42233.1 - 2.2 6.5 5.6 5.7 5.1 0.3 2.2 2 0 0 2 2 2 0 CDC45-like protein DUF3464 PF11947.8 EFE42233.1 - 2.8 7.7 10.9 0.46 10.2 0.4 2.6 3 0 0 3 3 2 0 Photosynthesis affected mutant 68 DUF4834 PF16118.5 EFE42233.1 - 3.1 8.8 7.5 13 6.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) GEN1_C PF18380.1 EFE42233.1 - 3.1 8.7 14.1 3 8.8 0.6 3.0 3 0 0 3 3 3 0 Holliday junction resolvase Gen1 C-terminal domain DUF719 PF05334.13 EFE42233.1 - 3.8 7.7 9.8 8.3 6.6 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF719) BHD_2 PF10404.9 EFE42233.1 - 3.8 8.5 14.7 17 6.4 0.1 3.3 3 0 0 3 3 3 0 Rad4 beta-hairpin domain 2 E7 PF00527.18 EFE42233.1 - 4.2 7.6 14.4 4.5 7.5 1.6 3.2 3 0 0 3 3 3 0 E7 protein, Early protein PRC2_HTH_1 PF18118.1 EFE42233.1 - 5.2 7.9 11.1 1.6 9.6 1.5 2.6 3 0 0 3 3 2 0 Polycomb repressive complex 2 tri-helical domain SPATIAL PF15256.6 EFE42233.1 - 5.9 7.2 6.4 15 5.9 0.6 2.4 2 0 0 2 2 2 0 SPATIAL Eapp_C PF10238.9 EFE42233.1 - 6.6 6.8 8.9 1.3 9.1 0.1 2.4 3 0 0 3 3 2 0 E2F-associated phosphoprotein RP-C_C PF11800.8 EFE42233.1 - 6.8 6.7 8.8 0.91 9.6 0.2 2.5 3 0 0 3 3 2 0 Replication protein C C-terminal region RR_TM4-6 PF06459.12 EFE42233.1 - 9.9 5.9 13.2 2.5 7.9 0.5 2.8 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 IF-2B PF01008.17 EFE42234.1 - 8.6e-51 172.8 0.0 4.2e-50 170.5 0.0 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.22 EFE42234.1 - 0.0089 16.0 0.0 0.83 9.6 0.0 2.3 2 0 0 2 2 2 2 DeoR C terminal sensor domain Peptidase_S46 PF10459.9 EFE42234.1 - 0.19 10.3 0.1 0.25 9.9 0.1 1.1 1 0 0 1 1 1 0 Peptidase S46 Nuf2 PF03800.14 EFE42235.1 - 6.7e-41 139.7 0.1 2.1e-40 138.1 0.1 1.9 1 0 0 1 1 1 1 Nuf2 family DHR10 PF18595.1 EFE42235.1 - 4.6e-30 104.1 17.1 4.6e-30 104.1 17.1 4.5 4 1 0 4 4 4 1 Designed helical repeat protein 10 domain Bac_luciferase PF00296.20 EFE42235.1 - 0.23 10.9 0.0 0.23 10.9 0.0 2.7 3 0 0 3 3 3 0 Luciferase-like monooxygenase Spc7 PF08317.11 EFE42235.1 - 0.95 8.3 54.1 4.2 6.2 14.7 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein FlaC_arch PF05377.11 EFE42235.1 - 1.4 9.3 22.7 0.63 10.5 1.1 5.2 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.11 EFE42235.1 - 2.2 8.9 35.5 0.11 13.0 1.9 4.6 3 1 1 4 4 4 0 Syntaxin 6, N-terminal VSG_B PF13206.6 EFE42235.1 - 2.6 7.2 0.0 2.6 7.2 0.0 3.2 1 1 2 3 3 3 0 Trypanosomal VSG domain DUF1664 PF07889.12 EFE42235.1 - 6.9 6.7 29.1 4.7 7.3 3.5 3.7 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) YvrJ PF12841.7 EFE42235.1 - 9.2 5.9 5.7 35 4.0 0.0 3.9 4 0 0 4 4 4 0 YvrJ protein family DUF2126 PF09899.9 EFE42236.1 - 0.026 12.6 0.3 0.034 12.2 0.3 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Eapp_C PF10238.9 EFE42236.1 - 0.067 13.3 3.2 0.083 13.0 3.2 1.3 1 1 0 1 1 1 0 E2F-associated phosphoprotein CDC45 PF02724.14 EFE42236.1 - 0.086 11.1 2.1 0.1 10.8 2.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4820 PF16091.5 EFE42236.1 - 0.098 12.0 2.4 0.14 11.5 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Zip PF02535.22 EFE42236.1 - 0.1 11.8 0.3 0.12 11.6 0.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter D123 PF07065.14 EFE42236.1 - 0.24 10.5 2.5 0.43 9.7 2.5 1.3 1 0 0 1 1 1 0 D123 Ribosomal_60s PF00428.19 EFE42236.1 - 0.28 11.8 7.2 0.083 13.5 3.6 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4746 PF15928.5 EFE42236.1 - 0.29 10.5 5.2 0.36 10.2 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Paf1 PF03985.13 EFE42236.1 - 0.34 9.8 7.7 0.46 9.4 7.7 1.1 1 0 0 1 1 1 0 Paf1 Sporozoite_P67 PF05642.11 EFE42236.1 - 2.8 5.9 4.3 3.6 5.5 4.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Adaptin_N PF01602.20 EFE42237.1 - 5.1e-96 322.3 0.0 6e-96 322.1 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFE42237.1 - 1.8e-16 60.6 0.0 5.9e-14 52.4 0.0 3.2 2 2 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFE42237.1 - 5.1e-10 39.6 1.4 0.00068 20.0 0.0 4.6 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 EFE42237.1 - 5.5e-07 29.3 0.5 0.14 12.5 0.0 5.0 5 0 0 5 5 5 2 HEAT repeat SPO22 PF08631.10 EFE42237.1 - 0.0017 17.9 0.6 0.64 9.4 0.1 3.2 3 0 0 3 3 3 1 Meiosis protein SPO22/ZIP4 like Cohesin_HEAT PF12765.7 EFE42237.1 - 0.0084 16.4 0.8 1.1 9.7 0.0 3.9 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion VHS PF00790.19 EFE42237.1 - 0.09 12.6 1.2 75 3.2 0.0 4.0 5 0 0 5 5 5 0 VHS domain Arm PF00514.23 EFE42237.1 - 0.44 10.7 1.8 7.8 6.7 0.2 3.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat CDC45 PF02724.14 EFE42237.1 - 9.4 4.4 18.0 20 3.3 18.0 1.5 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 EFE42238.1 - 5.5 6.7 7.3 6.2 6.6 0.4 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Metallophos PF00149.28 EFE42239.1 - 1.1e-36 127.2 0.3 1.6e-36 126.7 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFE42239.1 - 0.053 14.0 0.3 0.22 12.0 0.3 2.2 1 1 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Rho_GDI PF02115.17 EFE42240.1 - 2.3e-61 207.0 0.3 1.2e-60 204.7 0.3 1.8 1 1 0 1 1 1 1 RHO protein GDP dissociation inhibitor GFA PF04828.14 EFE42241.1 - 4.7e-05 23.6 0.4 4.7e-05 23.6 0.4 1.9 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Nudix_N_2 PF14803.6 EFE42241.1 - 0.0012 18.7 0.1 0.0012 18.7 0.1 2.5 3 0 0 3 3 3 1 Nudix N-terminal zf-NADH-PPase PF09297.11 EFE42241.1 - 0.0035 17.0 0.1 0.0035 17.0 0.1 2.2 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain CLP1_P PF16575.5 EFE42243.1 - 1.8e-34 119.2 0.0 1.6e-33 116.1 0.0 2.2 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EFE42243.1 - 7.1e-33 112.7 0.0 1.3e-32 111.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 EFE42243.1 - 1.6e-24 86.5 0.0 3.6e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ATP_bind_1 PF03029.17 EFE42243.1 - 0.00013 21.8 0.0 0.0028 17.5 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EFE42243.1 - 0.0082 16.2 0.0 0.058 13.5 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EFE42243.1 - 0.058 13.1 0.0 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFE42243.1 - 0.088 13.3 0.1 0.37 11.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter SRPRB PF09439.10 EFE42243.1 - 0.23 10.9 0.0 0.64 9.4 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Aminotran_5 PF00266.19 EFE42245.1 - 3.3e-10 39.5 0.0 4e-10 39.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_5 PF00266.19 EFE42246.1 - 1.6e-77 260.9 0.0 2.2e-77 260.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFE42246.1 - 3.8e-07 29.7 0.1 9.4e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EFE42246.1 - 2.9e-05 23.6 0.1 5.1e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Copper-bind PF00127.20 EFE42246.1 - 0.0032 17.9 0.2 0.0089 16.4 0.1 1.8 2 0 0 2 2 2 1 Copper binding proteins, plastocyanin/azurin family Pyridoxal_deC PF00282.19 EFE42246.1 - 0.022 13.5 0.0 0.036 12.8 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Cas_csx3 PF09620.10 EFE42246.1 - 0.057 13.3 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_csx3) Cys_Met_Meta_PP PF01053.20 EFE42246.1 - 0.082 11.4 0.0 0.13 10.8 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme LEA_6 PF10714.9 EFE42246.1 - 0.15 12.2 0.9 0.41 10.7 0.9 1.7 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 ATP_transf PF09830.9 EFE42247.1 - 2.8e-15 56.2 1.0 3.7e-15 55.8 0.1 1.7 2 0 0 2 2 2 1 ATP adenylyltransferase NB-ARC PF00931.22 EFE42248.1 - 1.1e-08 34.6 0.0 1.5e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EFE42248.1 - 4.3e-05 24.0 0.0 0.00013 22.4 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFE42248.1 - 0.0019 18.5 0.0 0.0047 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EFE42248.1 - 0.0024 17.8 0.0 0.0047 16.9 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea ATPase PF06745.13 EFE42248.1 - 0.013 14.9 0.0 0.037 13.4 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 EFE42248.1 - 0.069 12.7 0.0 1.8 8.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 EFE42248.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Zeta_toxin PF06414.12 EFE42248.1 - 0.18 11.1 0.0 0.77 9.0 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin GST_N PF02798.20 EFE42249.1 - 3.2e-17 62.6 0.0 6.1e-17 61.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFE42249.1 - 4.7e-17 62.2 0.0 8.8e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE42249.1 - 5e-11 42.7 0.0 8.7e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain motB PF17613.2 EFE42249.1 - 0.067 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Modifier of transcription Asp PF00026.23 EFE42250.1 - 3.6e-63 213.9 6.4 4.3e-63 213.6 6.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFE42250.1 - 9.4e-06 26.0 3.0 0.002 18.4 1.1 3.0 1 1 2 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFE42250.1 - 0.00077 20.1 1.0 1.3 9.7 0.3 3.1 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 EFE42250.1 - 0.0024 17.7 0.0 0.0066 16.2 0.0 1.9 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal AvrPphF-ORF-2 PF09143.10 EFE42250.1 - 0.073 13.0 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 AvrPphF-ORF-2 BAR PF03114.18 EFE42251.1 - 1.8e-66 224.2 7.7 2.2e-66 223.9 7.7 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EFE42251.1 - 5.1e-13 48.4 0.0 1e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE42251.1 - 1.3e-11 44.2 0.0 2.2e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFE42251.1 - 3e-07 30.0 0.1 8.2e-07 28.6 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain DUF3267 PF11667.8 EFE42251.1 - 0.64 10.3 2.4 1.1 9.6 2.4 1.3 1 0 0 1 1 1 0 Putative zincin peptidase BAR_3 PF16746.5 EFE42251.1 - 0.73 9.5 10.0 2.8 7.6 10.0 2.1 1 1 0 1 1 1 0 BAR domain of APPL family TMPIT PF07851.13 EFE42251.1 - 1.1 8.5 8.7 1.5 8.0 0.2 2.2 1 1 1 2 2 2 0 TMPIT-like protein BRE1 PF08647.11 EFE42251.1 - 1.8 8.7 10.7 0.91 9.6 0.2 2.4 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase APG6_N PF17675.1 EFE42251.1 - 4.2 7.9 10.8 16 6.0 5.0 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region AlaDh_PNT_N PF05222.15 EFE42252.1 - 5.5e-20 72.0 0.0 9.2e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EFE42252.1 - 0.0099 15.2 0.0 0.024 13.9 0.0 1.5 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Plant_all_beta PF10532.9 EFE42253.1 - 0.052 13.8 0.0 0.19 12.0 0.0 1.9 1 0 0 1 1 1 0 Plant specific N-all beta domain Palm_thioest PF02089.15 EFE42254.1 - 6.2e-83 278.4 0.0 7.4e-83 278.1 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EFE42254.1 - 0.0028 17.3 0.1 0.0054 16.4 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.11 EFE42254.1 - 0.012 15.0 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 EFE42254.1 - 0.048 14.3 0.0 0.062 13.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Acetyltransf_1 PF00583.25 EFE42255.1 - 3.8e-07 30.3 0.0 5.6e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFE42255.1 - 9.2e-07 29.2 0.0 1.6e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFE42255.1 - 4.1e-06 26.8 0.0 9.5e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE42255.1 - 0.0092 15.9 0.0 0.033 14.1 0.0 1.9 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.6 EFE42255.1 - 0.048 13.8 0.0 0.088 12.9 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF3328 PF11807.8 EFE42257.1 - 6e-29 101.4 0.6 1.2e-25 90.6 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF3328) R2K_2 PF18299.1 EFE42257.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 KTI12 PF08433.10 EFE42258.1 - 1.9e-26 93.2 0.0 1.4e-25 90.3 0.0 2.1 1 1 0 1 1 1 1 Chromatin associated protein KTI12 IL28A PF15177.6 EFE42259.1 - 0.095 12.5 0.7 0.21 11.5 0.7 1.4 1 0 0 1 1 1 0 Interleukin-28A zf-C2H2 PF00096.26 EFE42259.1 - 0.71 10.4 7.2 3.4 8.3 0.3 3.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type Peptidase_S10 PF00450.22 EFE42260.1 - 5e-93 312.8 0.2 6.4e-93 312.4 0.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Methyltransf_16 PF10294.9 EFE42261.1 - 7.7e-13 48.5 0.0 1.1e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFE42261.1 - 0.00078 19.3 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 EFE42261.1 - 0.0042 16.4 0.0 0.0064 15.8 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G NNMT_PNMT_TEMT PF01234.17 EFE42261.1 - 0.08 12.1 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family DUF3403 PF11883.8 EFE42261.1 - 0.16 12.1 0.1 0.36 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3403) PrmA PF06325.13 EFE42261.1 - 0.17 11.3 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CAML PF14963.6 EFE42262.1 - 0.86 9.7 5.1 1 9.5 5.1 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand TFIIA PF03153.13 EFE42262.1 - 3 7.8 26.1 4.2 7.3 26.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BAT2_N PF07001.11 EFE42262.1 - 4.9 7.6 17.0 5.8 7.3 17.0 1.2 1 0 0 1 1 1 0 BAT2 N-terminus Hid1 PF12722.7 EFE42262.1 - 9.7 4.2 12.8 11 4.0 12.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MFS_1 PF07690.16 EFE42263.1 - 8e-29 100.7 33.8 4.3e-26 91.7 22.5 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE42263.1 - 1.5e-07 30.7 0.6 1.5e-07 30.7 0.6 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EFE42263.1 - 0.00026 20.4 19.9 0.01 15.1 1.9 2.9 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB FUN14 PF04930.15 EFE42263.1 - 0.06 13.8 0.0 0.75 10.2 0.0 2.6 3 0 0 3 3 3 0 FUN14 family MFS_1_like PF12832.7 EFE42263.1 - 1.1 8.0 15.6 0.015 14.1 3.7 2.8 2 2 1 3 3 3 0 MFS_1 like family F-box PF00646.33 EFE42264.1 - 0.0027 17.5 0.0 0.0061 16.4 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE42264.1 - 0.11 12.4 0.0 0.33 10.9 0.0 1.8 1 0 0 1 1 1 0 F-box-like RR_TM4-6 PF06459.12 EFE42266.1 - 0.071 12.9 4.7 0.078 12.8 4.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 EFE42266.1 - 0.2 10.6 0.2 0.22 10.5 0.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RPN2_C PF18004.1 EFE42266.1 - 0.21 11.5 9.0 0.24 11.3 9.0 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain NARP1 PF12569.8 EFE42266.1 - 0.32 9.9 10.5 0.34 9.8 10.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 AP3D1 PF06375.11 EFE42266.1 - 0.64 10.2 12.5 0.87 9.8 12.5 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Connexin PF00029.19 EFE42266.1 - 1.5 8.5 5.2 1.7 8.3 5.2 1.1 1 0 0 1 1 1 0 Connexin U79_P34 PF03064.16 EFE42266.1 - 1.7 7.9 12.8 1.8 7.9 12.8 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Peptidase_S49_N PF08496.10 EFE42266.1 - 3.6 7.7 8.2 4.5 7.3 8.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Fungal_trans_2 PF11951.8 EFE42267.1 - 1e-99 334.0 0.5 1.3e-99 333.6 0.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE42267.1 - 1.4e-06 28.3 8.8 2.9e-06 27.3 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.32 EFE42268.1 - 2.4e-14 53.4 16.6 7.1e-05 23.5 0.9 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE42268.1 - 3.5e-12 46.5 0.4 0.0015 18.8 0.1 4.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EFE42268.1 - 0.039 13.5 0.1 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 PQQ-like domain UAF_Rrn10 PF05234.11 EFE42269.1 - 9.1e-05 22.7 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 UAF complex subunit Rrn10 Mnd1 PF03962.15 EFE42270.1 - 4.2e-21 75.0 0.1 1.7e-20 73.0 0.0 2.0 2 0 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 EFE42270.1 - 0.00084 19.4 0.3 0.0025 17.9 0.3 1.9 1 0 0 1 1 1 1 Leucine zipper with capping helix domain DUF5395 PF17373.2 EFE42270.1 - 0.048 14.3 0.1 0.17 12.5 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5395) BRE1 PF08647.11 EFE42270.1 - 0.3 11.2 11.0 5.5 7.1 7.7 3.0 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF1515 PF07439.11 EFE42270.1 - 0.32 11.0 1.9 0.54 10.3 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DUF1843 PF08898.10 EFE42270.1 - 0.54 10.8 3.2 8.9 6.9 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) CM_2 PF01817.21 EFE42270.1 - 0.68 10.3 4.2 0.62 10.5 2.0 2.1 2 0 0 2 2 2 0 Chorismate mutase type II TMCO5 PF14992.6 EFE42270.1 - 0.87 9.1 8.4 1.4 8.4 8.4 1.3 1 0 0 1 1 1 0 TMCO5 family DivIC PF04977.15 EFE42270.1 - 1.6 8.5 14.2 0.78 9.6 1.3 3.4 2 1 2 4 4 4 0 Septum formation initiator SlyX PF04102.12 EFE42270.1 - 2.7 8.7 6.1 14 6.4 1.3 3.1 2 1 0 2 2 2 0 SlyX Fib_alpha PF08702.10 EFE42270.1 - 9.4 6.4 9.8 2.2 8.5 4.8 2.2 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DHO_dh PF01180.21 EFE42271.1 - 1.5e-62 211.5 0.6 7.1e-55 186.3 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase FMN_dh PF01070.18 EFE42271.1 - 0.00069 18.8 0.0 0.0016 17.5 0.0 1.6 1 1 0 1 1 1 1 FMN-dependent dehydrogenase PcrB PF01884.17 EFE42271.1 - 0.2 11.1 0.3 3.4 7.1 0.0 2.3 2 0 0 2 2 2 0 PcrB family LacAB_rpiB PF02502.18 EFE42272.1 - 2.1e-43 147.6 0.2 2.4e-43 147.4 0.2 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase DUF2620 PF10941.8 EFE42272.1 - 0.041 14.0 0.0 0.057 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2620 TIM PF00121.18 EFE42273.1 - 5.1e-42 143.9 0.0 3.3e-41 141.3 0.0 1.9 1 1 0 1 1 1 1 Triosephosphate isomerase U-box PF04564.15 EFE42276.1 - 4.2e-23 81.3 0.1 9.1e-23 80.2 0.1 1.6 1 0 0 1 1 1 1 U-box domain CHIP_TPR_N PF18391.1 EFE42276.1 - 4.4e-06 27.4 5.7 7.3e-06 26.7 5.7 1.4 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_16 PF13432.6 EFE42276.1 - 1.1e-05 26.0 3.6 0.087 13.5 1.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFE42276.1 - 1.8e-05 24.5 9.4 0.097 12.8 3.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE42276.1 - 0.00042 20.5 6.6 0.025 14.8 1.7 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat zf-Nse PF11789.8 EFE42276.1 - 0.0036 17.1 0.1 0.012 15.4 0.1 1.8 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit TPR_1 PF00515.28 EFE42276.1 - 0.013 15.3 7.1 0.13 12.2 3.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-RING_UBOX PF13445.6 EFE42276.1 - 0.015 15.3 0.1 0.038 14.0 0.0 1.7 2 0 0 2 2 1 0 RING-type zinc-finger TPR_14 PF13428.6 EFE42276.1 - 0.017 15.9 0.5 2.4 9.2 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-NOSIP PF15906.5 EFE42276.1 - 0.023 14.8 0.0 0.046 13.9 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TPR_10 PF13374.6 EFE42276.1 - 0.026 14.4 0.9 1.6 8.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFE42276.1 - 0.068 13.7 3.7 4.4 7.9 0.1 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFE42276.1 - 0.088 12.5 7.6 0.7 9.6 2.9 2.8 3 0 0 3 3 3 0 TPR repeat TPR_4 PF07721.14 EFE42276.1 - 0.15 12.8 1.1 2.6 8.9 1.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ACBP PF00887.19 EFE42277.1 - 3.7e-19 68.7 0.2 4.3e-19 68.5 0.2 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein Tyr-DNA_phospho PF06087.12 EFE42278.1 - 2e-165 550.8 0.0 2.4e-165 550.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EFE42278.1 - 0.0027 17.6 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain AA_permease_2 PF13520.6 EFE42279.1 - 2.9e-34 118.6 22.9 2.9e-34 118.6 22.9 1.3 1 1 0 1 1 1 1 Amino acid permease ABC_membrane PF00664.23 EFE42280.1 - 4e-62 210.4 35.7 7e-39 134.1 19.2 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EFE42280.1 - 1.2e-47 161.9 0.3 4.4e-27 95.3 0.2 2.8 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 EFE42280.1 - 3.2e-06 27.7 0.8 0.16 12.3 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EFE42280.1 - 4e-06 26.9 0.9 0.024 14.7 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase SMC_N PF02463.19 EFE42280.1 - 1.4e-05 24.6 6.1 0.74 9.2 0.1 4.0 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFE42280.1 - 5.5e-05 23.1 3.2 0.13 12.1 0.0 3.9 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFE42280.1 - 0.00023 21.1 1.5 0.1 12.5 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 EFE42280.1 - 0.00044 19.6 0.0 0.081 12.2 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Dynamin_N PF00350.23 EFE42280.1 - 0.00054 20.1 0.1 0.24 11.4 0.1 2.5 2 0 0 2 2 2 1 Dynamin family AAA_29 PF13555.6 EFE42280.1 - 0.00078 19.1 1.5 0.49 10.2 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MeaB PF03308.16 EFE42280.1 - 0.0025 16.9 2.2 0.4 9.6 0.2 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 EFE42280.1 - 0.0034 17.2 0.2 1.6 8.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 EFE42280.1 - 0.0095 16.5 6.1 0.34 11.4 0.2 3.1 3 0 0 3 3 2 2 AAA domain DUF87 PF01935.17 EFE42280.1 - 0.016 15.3 2.6 0.13 12.3 0.5 2.8 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_18 PF13238.6 EFE42280.1 - 0.017 15.7 0.0 6.4 7.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFE42280.1 - 0.031 14.5 2.3 4.7 7.5 0.1 3.2 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFE42280.1 - 0.033 13.9 0.1 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein YqzM PF14141.6 EFE42280.1 - 0.035 14.2 0.1 0.11 12.6 0.1 1.9 1 0 0 1 1 1 0 YqzM-like protein AAA_30 PF13604.6 EFE42280.1 - 0.1 12.3 2.6 4.2 7.0 0.2 2.8 3 0 0 3 3 2 0 AAA domain Roc PF08477.13 EFE42280.1 - 0.1 12.8 0.1 24 5.1 0.1 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_27 PF13514.6 EFE42280.1 - 0.12 12.0 0.1 6.5 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFE42280.1 - 0.17 12.3 0.2 13 6.2 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Ploopntkinase3 PF18751.1 EFE42280.1 - 0.22 11.4 3.4 16 5.4 0.1 3.1 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 AAA_28 PF13521.6 EFE42280.1 - 0.85 9.8 5.4 0.42 10.8 0.1 2.7 3 0 0 3 3 2 0 AAA domain Aminotran_3 PF00202.21 EFE42281.1 - 4.3e-117 391.2 0.0 5e-117 391.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EFE42281.1 - 0.014 14.7 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Glyco_transf_22 PF03901.17 EFE42282.1 - 2.4e-08 33.7 0.0 2.7e-08 33.5 0.0 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Glyco_transf_22 PF03901.17 EFE42283.1 - 2e-39 136.0 6.4 2.7e-39 135.6 6.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF1980 PF09323.10 EFE42283.1 - 0.82 9.6 2.7 0.53 10.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) ArfGap PF01412.18 EFE42284.1 - 0.055 13.5 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf UBA PF00627.31 EFE42284.1 - 0.097 12.6 0.0 0.78 9.7 0.0 2.2 2 0 0 2 2 2 0 UBA/TS-N domain SET PF00856.28 EFE42285.1 - 1.6e-06 28.6 5.2 5.2e-06 27.0 1.1 3.1 2 1 0 2 2 2 1 SET domain PHD PF00628.29 EFE42285.1 - 5.5e-06 26.2 9.6 1.3e-05 24.9 9.6 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EFE42285.1 - 0.46 10.1 5.4 0.85 9.2 5.4 1.4 1 0 0 1 1 1 0 PHD-finger ORC4_C PF14629.6 EFE42286.1 - 5.1e-45 153.5 0.0 8.8e-45 152.7 0.0 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EFE42286.1 - 1.5e-18 67.7 0.1 3.7e-18 66.5 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFE42286.1 - 8.7e-06 26.1 0.1 2.7e-05 24.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.13 EFE42286.1 - 0.00018 20.8 0.0 0.0003 20.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA PF00004.29 EFE42286.1 - 0.0004 20.8 0.0 0.0014 19.0 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EFE42286.1 - 0.0031 17.8 0.0 0.0077 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EFE42286.1 - 0.013 15.4 0.2 0.062 13.2 0.2 2.0 1 1 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 EFE42286.1 - 0.045 13.8 0.2 0.14 12.1 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EFE42286.1 - 0.046 13.2 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region Dicty_REP PF05086.12 EFE42286.1 - 0.12 10.3 10.3 0.21 9.5 10.3 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ATPase_2 PF01637.18 EFE42286.1 - 0.13 12.2 0.0 0.62 9.9 0.0 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 EFE42286.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family ACOX PF01756.19 EFE42287.1 - 0.049 13.2 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA oxidase DNA_pol_B_palm PF14792.6 EFE42290.1 - 2.4e-33 114.7 0.0 4.7e-33 113.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EFE42290.1 - 9.6e-23 80.1 0.0 2.2e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EFE42290.1 - 4.7e-20 71.1 0.6 1.6e-19 69.4 0.3 2.1 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 EFE42290.1 - 7.8e-18 64.6 1.1 1.8e-17 63.5 1.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 EFE42290.1 - 0.0039 17.5 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH_5 PF14520.6 EFE42290.1 - 0.03 14.9 0.1 11 6.7 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix domain Cdd1 PF11731.8 EFE42290.1 - 0.11 12.7 0.0 1.1 9.6 0.0 2.6 3 1 0 3 3 3 0 Pathogenicity locus ATP-synt_10 PF05176.14 EFE42291.1 - 3.5e-77 259.1 0.0 4.7e-77 258.7 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein V-SNARE_C PF12352.8 EFE42292.1 - 4.4e-16 58.9 7.0 2.5e-15 56.5 0.1 2.9 3 0 0 3 3 3 2 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EFE42292.1 - 0.017 15.1 0.9 4.2 7.4 0.0 2.6 2 1 1 3 3 3 0 Sec20 AAA_13 PF13166.6 EFE42292.1 - 0.019 13.7 1.5 0.021 13.5 1.5 1.1 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 EFE42292.1 - 0.1 11.4 3.3 0.13 11.1 3.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 EFE42292.1 - 0.34 10.7 4.9 5.5 6.8 1.0 2.6 1 1 1 2 2 2 0 Septum formation initiator Ribosomal_L29 PF00831.23 EFE42293.1 - 1.8e-17 63.1 0.3 1.8e-17 63.1 0.3 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein Phe_tRNA-synt_N PF02912.18 EFE42293.1 - 0.091 12.7 0.2 0.091 12.7 0.2 2.3 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain Med16 PF11635.8 EFE42294.1 - 1.8e-147 492.5 0.0 1.7e-146 489.2 0.0 1.9 1 1 1 2 2 2 2 Mediator complex subunit 16 ANAPC4_WD40 PF12894.7 EFE42294.1 - 0.001 19.3 0.0 2.5 8.5 0.0 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain SIR2 PF02146.17 EFE42295.1 - 9.8e-27 94.0 0.0 3.9e-26 92.0 0.0 1.9 1 1 0 1 1 1 1 Sir2 family CBFD_NFYB_HMF PF00808.23 EFE42296.1 - 6.1e-06 26.4 0.0 9.6e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone GN3L_Grn1 PF08701.11 EFE42297.1 - 3.2e-24 84.8 17.1 3.2e-24 84.8 17.1 2.7 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EFE42297.1 - 3.2e-18 65.9 0.7 4e-13 49.4 0.0 2.7 2 1 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFE42297.1 - 5.1e-07 29.7 0.1 3e-06 27.2 0.1 2.1 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EFE42297.1 - 8.3e-06 25.4 0.1 6.4e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EFE42297.1 - 0.00077 19.1 0.6 0.6 9.6 0.1 3.4 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFE42297.1 - 0.0014 18.7 9.4 0.82 9.7 0.2 4.2 2 2 0 3 3 3 2 Dynamin family cobW PF02492.19 EFE42297.1 - 0.035 13.7 1.9 0.8 9.3 0.0 3.2 3 1 1 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EFE42297.1 - 0.049 12.6 0.1 0.049 12.6 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 EFE42297.1 - 0.067 12.5 0.1 0.067 12.5 0.1 2.4 3 0 0 3 3 3 0 AIG1 family Roc PF08477.13 EFE42297.1 - 0.098 12.9 0.0 11 6.3 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EFE42297.1 - 0.47 10.8 0.0 0.47 10.8 0.0 3.2 2 1 0 2 2 1 0 AAA ATPase domain AAA_18 PF13238.6 EFE42297.1 - 0.57 10.7 0.0 0.57 10.7 0.0 2.7 3 1 0 3 3 3 0 AAA domain HAD_2 PF13419.6 EFE42298.1 - 6.3e-14 52.5 0.0 8.5e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFE42298.1 - 6.2e-07 29.9 0.0 3.4e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE42298.1 - 0.00033 20.7 0.1 0.00087 19.3 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EFE42298.1 - 0.047 13.8 0.0 0.74 10.0 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Homeodomain PF00046.29 EFE42299.1 - 1.5e-16 60.0 1.5 1.5e-15 56.8 2.7 2.0 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EFE42299.1 - 0.00049 20.0 1.1 0.0013 18.6 1.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain DUF4638 PF15472.6 EFE42299.1 - 0.15 11.8 6.6 0.26 11.0 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) SDP_N PF12278.8 EFE42299.1 - 1.6 8.9 11.3 3.9 7.6 11.3 1.6 1 0 0 1 1 1 0 Sex determination protein N terminal MCM_bind PF09739.9 EFE42299.1 - 2.2 6.6 10.5 3.8 5.8 10.5 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor BTB PF00651.31 EFE42300.1 - 1.3e-05 25.4 0.0 2.2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain RabGAP-TBC PF00566.18 EFE42301.1 - 7.3e-36 123.8 0.0 1.2e-35 123.2 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DPCD PF14913.6 EFE42301.1 - 0.031 13.6 0.2 0.068 12.5 0.2 1.5 1 0 0 1 1 1 0 DPCD protein family TPP_enzyme_N PF02776.18 EFE42302.1 - 7.5e-41 139.6 0.0 1.4e-40 138.7 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EFE42302.1 - 1.9e-18 66.7 0.0 4e-17 62.4 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EFE42302.1 - 7.1e-14 51.7 0.0 1.3e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Mo25 PF08569.11 EFE42303.1 - 1.8e-109 366.1 0.0 2.9e-108 362.1 0.0 2.2 1 1 0 1 1 1 1 Mo25-like Terminase_6C PF17289.2 EFE42303.1 - 0.084 13.0 0.0 3.8 7.6 0.0 2.5 2 1 0 2 2 2 0 Terminase RNaseH-like domain Methyltransf_25 PF13649.6 EFE42304.1 - 2.3e-10 41.0 0.0 6.2e-10 39.7 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE42304.1 - 6e-09 35.9 0.0 1.2e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFE42304.1 - 1.7e-08 34.2 0.0 2.9e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 EFE42304.1 - 2e-08 34.7 0.0 4.8e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE42304.1 - 9e-06 25.6 0.0 1.7e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EFE42304.1 - 3.9e-05 23.6 0.0 7.3e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFE42304.1 - 0.00011 21.8 0.1 0.00019 21.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 EFE42304.1 - 0.00034 19.6 0.0 0.00051 19.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.12 EFE42304.1 - 0.012 16.4 0.0 0.025 15.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain RasGAP_C PF03836.15 EFE42304.1 - 0.019 15.1 0.3 0.045 13.9 0.3 1.5 1 0 0 1 1 1 0 RasGAP C-terminus PCMT PF01135.19 EFE42304.1 - 0.025 14.4 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 EFE42304.1 - 0.027 13.9 0.0 0.047 13.1 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB CMAS PF02353.20 EFE42304.1 - 0.049 12.9 0.0 0.2 10.9 0.0 2.0 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 EFE42304.1 - 0.067 14.2 0.0 0.17 12.9 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EFE42304.1 - 0.067 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EFE42304.1 - 0.083 12.9 0.2 0.19 11.7 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Cir_N PF10197.9 EFE42305.1 - 1.9e-06 28.0 8.4 1.9e-06 28.0 8.4 4.8 4 1 1 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR AAA PF00004.29 EFE42306.1 - 1.1e-53 181.2 0.0 1.4e-38 132.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE42306.1 - 9.6e-11 41.3 0.0 2.2e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EFE42306.1 - 4.3e-10 40.2 0.0 0.00086 19.7 0.0 3.1 3 0 0 3 3 2 2 AAA ATPase domain CDC48_2 PF02933.17 EFE42306.1 - 8e-10 38.4 0.1 2.1e-08 33.8 0.0 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 EFE42306.1 - 2.2e-09 37.7 0.0 0.00039 20.7 0.0 3.8 3 1 0 3 3 3 2 AAA domain AAA_5 PF07728.14 EFE42306.1 - 2.2e-08 34.2 0.0 0.0015 18.5 0.0 2.8 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFE42306.1 - 3.7e-08 33.3 0.1 0.0076 16.0 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFE42306.1 - 3.7e-08 34.0 0.0 0.016 15.7 0.0 3.5 3 0 0 3 3 3 2 AAA domain TIP49 PF06068.13 EFE42306.1 - 7.1e-08 32.0 0.0 0.0068 15.7 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_14 PF13173.6 EFE42306.1 - 1.4e-07 31.6 0.0 0.088 12.8 0.0 3.4 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 EFE42306.1 - 2.2e-07 30.5 0.1 0.0046 16.4 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EFE42306.1 - 2.4e-07 31.0 0.0 6.6e-05 23.1 0.0 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 EFE42306.1 - 7.8e-07 29.5 0.0 0.061 13.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.6 EFE42306.1 - 9.7e-07 29.0 0.0 0.03 14.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EFE42306.1 - 4e-06 26.7 0.0 0.013 15.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 EFE42306.1 - 1.4e-05 25.2 0.0 4.2e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain IstB_IS21 PF01695.17 EFE42306.1 - 1.5e-05 24.9 0.0 0.08 12.7 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein NACHT PF05729.12 EFE42306.1 - 3.5e-05 23.8 1.3 0.029 14.3 0.0 3.1 3 1 0 3 3 2 1 NACHT domain TsaE PF02367.17 EFE42306.1 - 3.8e-05 23.7 0.0 0.23 11.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EFE42306.1 - 3.8e-05 23.0 0.3 0.098 11.8 0.0 2.7 3 0 0 3 3 3 2 NB-ARC domain ATPase PF06745.13 EFE42306.1 - 5.9e-05 22.5 0.4 0.019 14.3 0.2 2.6 2 0 0 2 2 2 1 KaiC AAA_7 PF12775.7 EFE42306.1 - 7.1e-05 22.4 1.0 0.023 14.2 0.0 2.7 3 0 0 3 3 2 1 P-loop containing dynein motor region AAA_28 PF13521.6 EFE42306.1 - 0.00015 22.1 0.0 0.5 10.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 EFE42306.1 - 0.00028 21.3 0.1 0.16 12.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EFE42306.1 - 0.00028 21.4 0.3 0.047 14.2 0.1 2.7 2 0 0 2 2 2 1 ABC transporter AAA_11 PF13086.6 EFE42306.1 - 0.00032 20.6 0.0 0.55 10.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EFE42306.1 - 0.00033 20.3 0.3 1 8.9 0.1 2.8 2 1 0 2 2 2 2 AAA domain AAA_3 PF07726.11 EFE42306.1 - 0.00039 20.3 0.0 0.51 10.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EFE42306.1 - 0.00051 19.5 0.2 1.2 8.5 0.0 2.7 3 0 0 3 3 3 2 PhoH-like protein Sigma54_activat PF00158.26 EFE42306.1 - 0.00061 19.5 0.0 0.57 9.9 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.6 EFE42306.1 - 0.00083 19.7 0.1 0.5 10.7 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EFE42306.1 - 0.00086 19.1 0.1 0.38 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EFE42306.1 - 0.0028 16.9 0.1 1.5 7.9 0.1 2.5 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.17 EFE42306.1 - 0.0036 16.4 0.0 0.42 9.7 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 ATPase_2 PF01637.18 EFE42306.1 - 0.0036 17.2 0.6 15 5.4 0.0 3.4 3 1 1 4 4 3 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 EFE42306.1 - 0.01 15.8 0.1 7.4 6.5 0.0 3.0 3 0 0 3 3 2 0 NTPase ResIII PF04851.15 EFE42306.1 - 0.012 15.6 0.0 4.9 7.1 0.1 3.0 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 EFE42306.1 - 0.017 14.4 0.0 1.6 7.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin KTI12 PF08433.10 EFE42306.1 - 0.021 14.3 0.1 1.7 8.0 0.0 2.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 TniB PF05621.11 EFE42306.1 - 0.025 14.0 0.2 3.8 6.9 0.1 3.3 3 1 0 3 3 3 0 Bacterial TniB protein Vps4_C PF09336.10 EFE42306.1 - 0.047 13.7 0.0 0.21 11.6 0.0 2.2 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain SRP54 PF00448.22 EFE42306.1 - 0.064 12.9 0.2 5.4 6.6 0.0 2.9 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain IPT PF01745.16 EFE42306.1 - 0.096 12.1 0.0 1.3 8.3 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase AAA_29 PF13555.6 EFE42306.1 - 0.11 12.2 0.1 10 5.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Sigma54_activ_2 PF14532.6 EFE42306.1 - 0.13 12.4 0.0 28 4.8 0.0 3.1 3 0 0 3 3 3 0 Sigma-54 interaction domain KxDL PF10241.9 EFE42308.1 - 2.7e-18 66.0 1.2 5.8e-15 55.3 0.2 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein HATPase_c PF02518.26 EFE42310.1 - 2.9e-21 76.1 0.7 9.2e-21 74.5 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFE42310.1 - 9.1e-17 61.2 0.0 1.9e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFE42310.1 - 8e-16 57.8 0.0 2.6e-15 56.2 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EFE42310.1 - 2.2e-11 43.9 1.0 0.00092 19.5 0.1 3.9 3 0 0 3 3 3 3 PAS fold PAS_4 PF08448.10 EFE42310.1 - 1e-05 25.7 0.1 4.1e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 EFE42310.1 - 0.00026 20.9 0.0 0.34 10.9 0.0 3.5 3 0 0 3 3 3 2 PAS fold SUIM_assoc PF16619.5 EFE42310.1 - 0.0072 16.4 10.6 0.0072 16.4 10.6 3.2 3 0 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 PAS_9 PF13426.7 EFE42310.1 - 0.017 15.4 0.1 6.1 7.1 0.0 3.9 4 0 0 4 4 4 0 PAS domain MotA_ExbB PF01618.16 EFE42310.1 - 0.26 11.0 0.6 0.9 9.3 0.0 2.1 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family HATPase_c PF02518.26 EFE42312.1 - 2e-31 108.8 0.0 6e-31 107.2 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFE42312.1 - 8.3e-20 71.0 0.0 2.4e-19 69.5 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFE42312.1 - 1.8e-19 69.5 0.0 1.4e-18 66.6 0.0 2.7 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain AAA_16 PF13191.6 EFE42312.1 - 1.2e-10 42.0 0.0 1.1e-09 38.9 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain GAF_2 PF13185.6 EFE42312.1 - 7.1e-10 39.3 0.0 3.5e-09 37.1 0.0 2.3 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EFE42312.1 - 8.1e-07 29.7 0.0 2.6e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 GAF domain Pkinase PF00069.25 EFE42312.1 - 5.4e-06 26.0 0.0 8.5e-05 22.0 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain GAF_3 PF13492.6 EFE42312.1 - 5e-05 23.6 0.0 0.00012 22.4 0.0 1.7 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 EFE42312.1 - 5.9e-05 22.9 0.0 0.00014 21.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NB-ARC PF00931.22 EFE42312.1 - 0.00022 20.5 0.0 0.025 13.8 0.0 2.9 3 0 0 3 3 3 1 NB-ARC domain AAA_22 PF13401.6 EFE42312.1 - 0.0074 16.6 0.0 1.3 9.3 0.0 3.2 3 0 0 3 3 3 1 AAA domain MeaB PF03308.16 EFE42312.1 - 0.027 13.5 0.0 0.053 12.5 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TPR_2 PF07719.17 EFE42312.1 - 0.072 13.2 3.2 5.5 7.3 0.2 3.6 3 0 0 3 3 2 0 Tetratricopeptide repeat AAA_35 PF14516.6 EFE42312.1 - 0.098 11.5 0.0 0.3 9.9 0.0 1.7 2 0 0 2 2 2 0 AAA-like domain AAA_33 PF13671.6 EFE42312.1 - 0.15 12.3 0.0 1.7 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain Allantoicase PF03561.15 EFE42313.1 - 1.1e-87 291.3 0.0 1.1e-43 148.7 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat Cytochrom_B561 PF03188.16 EFE42314.1 - 2.6e-16 60.0 2.1 2.6e-16 60.0 2.1 1.4 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 EFE42314.1 - 0.059 13.5 6.1 0.66 10.1 6.1 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) DUF2306 PF10067.9 EFE42314.1 - 0.081 13.1 5.3 0.5 10.6 0.5 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) Ni_hydr_CYTB PF01292.20 EFE42314.1 - 0.1 12.2 6.5 0.85 9.2 6.5 2.3 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 DUF2818 PF10993.8 EFE42314.1 - 0.1 13.2 3.8 0.28 11.8 1.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2818) DUF2427 PF10348.9 EFE42314.1 - 0.31 10.8 4.5 0.94 9.3 0.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) tRNA-synt_2b PF00587.25 EFE42315.1 - 6.1e-21 75.2 0.0 1.4e-20 74.0 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EFE42315.1 - 7.9e-09 35.7 2.2 1.5e-08 34.9 2.2 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 EFE42315.1 - 0.00091 17.9 3.5 0.0013 17.4 3.5 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A tRNA-synt_His PF13393.6 EFE42315.1 - 0.029 13.6 1.0 1.6 7.9 1.1 2.2 2 0 0 2 2 2 0 Histidyl-tRNA synthetase Flagellar_rod PF05149.12 EFE42315.1 - 0.039 13.4 1.9 0.057 12.9 1.9 1.2 1 0 0 1 1 1 0 Paraflagellar rod protein DUF4694 PF15765.5 EFE42315.1 - 0.057 13.5 0.8 0.17 11.9 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4694) TMF_TATA_bd PF12325.8 EFE42315.1 - 0.062 13.5 1.6 0.12 12.7 1.6 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 EFE42315.1 - 0.096 11.6 2.8 0.17 10.7 2.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Nebulin PF00880.18 EFE42315.1 - 0.14 12.0 0.1 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Nebulin repeat BLOC1_2 PF10046.9 EFE42315.1 - 0.24 11.7 1.6 5.5 7.4 0.0 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tektin PF03148.14 EFE42315.1 - 0.48 9.1 6.1 0.64 8.7 1.9 2.0 1 1 1 2 2 2 0 Tektin family DivIC PF04977.15 EFE42315.1 - 0.66 9.8 7.0 4.5 7.1 0.4 2.4 1 1 1 2 2 2 0 Septum formation initiator KELK PF15796.5 EFE42315.1 - 0.72 10.3 6.9 0.85 10.1 5.3 1.9 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase OmpH PF03938.14 EFE42315.1 - 1.2 9.5 6.1 2.1 8.7 6.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 EFE42315.1 - 2.4 7.4 5.8 1.6 8.0 3.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) JIP_LZII PF16471.5 EFE42315.1 - 2.6 8.3 4.8 25 5.1 0.1 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II HSCB_C PF07743.13 EFE42315.1 - 2.9 8.4 7.2 4.4 7.9 2.7 2.3 1 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain TMF_DNA_bd PF12329.8 EFE42315.1 - 4.9 7.2 6.5 9.8 6.3 1.1 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF2205 PF10224.9 EFE42315.1 - 5.1 7.2 6.4 7.5 6.6 0.2 2.4 1 1 1 2 2 2 0 Short coiled-coil protein APH PF01636.23 EFE42316.1 - 0.0013 18.7 0.0 0.0023 17.9 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE42316.1 - 0.0017 17.3 0.0 0.0036 16.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Pkinase PF00069.25 EFE42317.1 - 5.5e-05 22.7 0.6 0.015 14.6 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain ABC_membrane PF00664.23 EFE42318.1 - 9.7e-89 297.7 43.4 2.3e-49 168.5 14.7 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EFE42318.1 - 2e-68 229.2 0.1 4.7e-33 114.6 0.0 3.2 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EFE42318.1 - 1.9e-13 50.4 4.6 0.00053 19.5 0.1 4.4 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFE42318.1 - 3.2e-09 36.9 0.0 0.00077 19.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EFE42318.1 - 1.7e-08 34.1 0.3 0.0024 17.6 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFE42318.1 - 9.7e-08 32.6 0.1 0.013 15.9 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFE42318.1 - 1.2e-06 28.8 1.4 0.15 12.3 0.1 4.1 2 2 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 EFE42318.1 - 2.7e-06 26.5 1.6 0.16 10.7 0.1 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA PF00004.29 EFE42318.1 - 9.1e-06 26.1 1.8 0.021 15.2 0.1 4.0 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EFE42318.1 - 3.2e-05 23.6 0.1 0.37 10.4 0.1 2.9 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.14 EFE42318.1 - 3.3e-05 23.9 0.0 0.026 14.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 EFE42318.1 - 4.4e-05 23.4 2.2 0.71 9.6 0.3 4.1 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFE42318.1 - 6.9e-05 22.7 0.4 0.35 10.5 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 EFE42318.1 - 0.00022 21.3 0.0 0.065 13.3 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EFE42318.1 - 0.00022 21.8 1.5 0.42 11.1 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EFE42318.1 - 0.00031 20.5 1.5 1 9.1 0.1 3.9 3 1 0 3 3 3 2 AAA domain AAA_28 PF13521.6 EFE42318.1 - 0.00042 20.6 0.5 1.9 8.7 0.0 3.5 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFE42318.1 - 0.00061 19.4 0.1 0.31 10.5 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_33 PF13671.6 EFE42318.1 - 0.0024 18.1 0.0 1.2 9.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFE42318.1 - 0.0042 17.5 0.1 0.25 11.8 0.0 2.6 2 0 0 2 2 2 1 RNA helicase SbcCD_C PF13558.6 EFE42318.1 - 0.0055 16.9 2.8 6.3 7.1 0.4 4.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 EFE42318.1 - 0.0078 16.8 0.1 6.4 7.3 0.0 2.9 3 0 0 3 3 2 0 AAA domain G-alpha PF00503.20 EFE42318.1 - 0.014 14.6 0.0 4.9 6.2 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit Rad17 PF03215.15 EFE42318.1 - 0.016 15.1 0.0 0.19 11.7 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain Zeta_toxin PF06414.12 EFE42318.1 - 0.022 14.0 0.0 2.5 7.3 0.0 2.9 2 0 0 2 2 2 0 Zeta toxin AAA_14 PF13173.6 EFE42318.1 - 0.051 13.6 0.0 4.9 7.2 0.0 3.6 4 0 0 4 4 3 0 AAA domain SRP54 PF00448.22 EFE42318.1 - 0.084 12.5 0.3 5.8 6.5 0.1 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain APS_kinase PF01583.20 EFE42318.1 - 0.13 12.2 0.2 2.6 7.9 0.1 2.7 2 1 0 2 2 2 0 Adenylylsulphate kinase DUF87 PF01935.17 EFE42318.1 - 0.13 12.3 0.1 2.4 8.2 0.2 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_17 PF13207.6 EFE42318.1 - 0.29 11.6 1.0 53 4.2 0.0 3.3 4 0 0 4 4 3 0 AAA domain DUF3632 PF12311.8 EFE42319.1 - 9e-30 104.4 0.1 1.2e-29 103.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) AMP-binding PF00501.28 EFE42320.1 - 6.9e-50 169.9 0.4 3.9e-49 167.4 0.4 1.8 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE42320.1 - 0.015 16.3 0.0 0.054 14.5 0.0 2.0 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain MFS_1 PF07690.16 EFE42321.1 - 1.1e-28 100.2 38.5 1.1e-28 100.2 38.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Imm57 PF15596.6 EFE42321.1 - 0.14 12.5 0.0 0.26 11.6 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 57 UNC-93 PF05978.16 EFE42321.1 - 0.16 11.7 4.8 0.41 10.4 4.5 1.9 1 1 0 1 1 1 0 Ion channel regulatory protein UNC-93 Gln-synt_C PF00120.24 EFE42322.1 - 6.6e-16 58.2 0.0 6.7e-13 48.4 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EFE42322.1 - 1.5e-10 40.7 0.0 5.4e-10 38.9 0.0 1.8 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain Med1 PF10744.9 EFE42324.1 - 1.6e-137 459.0 0.0 5.1e-137 457.3 0.0 1.7 2 0 0 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 SRAP PF02586.14 EFE42326.1 - 4.2e-80 268.4 0.0 5.7e-80 268.0 0.0 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) TPR_2 PF07719.17 EFE42327.1 - 3.9e-05 23.4 5.5 0.12 12.5 0.3 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFE42327.1 - 5.4e-05 22.8 5.5 0.018 14.8 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE42327.1 - 0.00013 22.2 13.6 0.028 14.7 0.3 5.3 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFE42327.1 - 0.0036 17.2 4.5 4.7 7.5 0.1 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFE42327.1 - 0.19 12.0 14.8 0.59 10.5 0.0 4.7 6 1 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.32 EFE42328.1 - 1.6e-42 142.6 24.5 1.3e-09 38.5 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE42328.1 - 1.8e-09 37.8 0.2 0.065 13.5 0.0 4.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE42328.1 - 3.3e-05 22.7 6.1 0.082 11.5 0.2 4.2 2 2 2 5 5 5 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFE42328.1 - 0.003 16.6 0.0 1.2 8.0 0.0 3.7 2 2 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EFE42328.1 - 0.02 14.8 0.2 21 5.2 0.0 4.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EFE42328.1 - 0.024 13.1 0.0 2.3 6.7 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain WD40_like PF17005.5 EFE42328.1 - 0.05 12.9 0.0 2.1 7.6 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Sdh5 PF03937.16 EFE42329.1 - 9.1e-09 35.2 0.1 4.6e-08 32.9 0.1 1.9 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase EMP24_GP25L PF01105.24 EFE42330.1 - 1.7e-39 135.6 0.0 2.2e-39 135.3 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD CENP-R PF06729.12 EFE42331.1 - 8.1 6.4 8.5 0.41 10.6 2.0 2.2 2 0 0 2 2 2 0 Kinetochore component, CENP-R DUF3328 PF11807.8 EFE42332.1 - 0.2 11.4 2.4 7.2 6.3 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) Nop14 PF04147.12 EFE42334.1 - 0.14 10.3 23.6 0.18 10.0 23.6 1.2 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EFE42334.1 - 0.32 9.0 30.8 0.46 8.5 30.8 1.3 1 0 0 1 1 1 0 DNA polymerase phi Spore_coat_CotO PF14153.6 EFE42334.1 - 2.6 7.9 8.5 12 5.8 8.5 2.0 1 1 0 1 1 1 0 Spore coat protein CotO PI3K_1B_p101 PF10486.9 EFE42334.1 - 7 4.3 5.5 9.7 3.8 5.5 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RNA_pol_I_A49 PF06870.12 EFE42335.1 - 0.012 14.5 0.6 0.014 14.2 0.6 1.1 1 0 0 1 1 1 0 A49-like RNA polymerase I associated factor Ashwin PF15323.6 EFE42335.1 - 1.3 9.0 8.4 0.51 10.3 1.2 2.0 1 1 1 2 2 2 0 Developmental protein SUIM_assoc PF16619.5 EFE42335.1 - 1.5 8.9 10.8 11 6.2 0.4 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 NDUFA12 PF05071.16 EFE42337.1 - 6.6e-07 30.1 7.6 3.8e-06 27.7 7.6 2.1 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 CH PF00307.31 EFE42338.1 - 6e-14 52.2 0.0 1.1e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 EFE42338.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 CDC24 Calponin CAMSAP_CH PF11971.8 EFE42338.1 - 0.19 11.6 0.0 0.43 10.4 0.0 1.6 1 1 0 1 1 1 0 CAMSAP CH domain Calponin PF00402.18 EFE42338.1 - 0.54 9.9 6.9 1.1 8.9 1.3 2.7 2 0 0 2 2 2 0 Calponin family repeat PGA2 PF07543.12 EFE42339.1 - 0.82 9.6 6.8 1.9 8.5 5.8 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 DUF3381 PF11861.8 EFE42339.1 - 1.1 9.0 7.3 2.3 8.0 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) ORMDL PF04061.14 EFE42341.1 - 5.4e-56 188.1 4.7 6.6e-56 187.9 4.7 1.1 1 0 0 1 1 1 1 ORMDL family APH PF01636.23 EFE42343.1 - 1.4e-12 48.1 0.0 4.8e-12 46.3 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE42343.1 - 0.011 15.3 0.1 0.019 14.5 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 EFE42343.1 - 0.014 14.3 0.0 0.024 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) EcKinase PF02958.20 EFE42343.1 - 0.015 14.6 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase Arm PF00514.23 EFE42347.1 - 1.7e-66 218.4 27.4 4.8e-11 42.3 0.1 11.2 11 0 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFE42347.1 - 8.6e-15 54.9 19.1 0.022 15.3 0.5 8.0 8 1 1 9 9 8 5 HEAT-like repeat HEAT_2 PF13646.6 EFE42347.1 - 1.6e-13 50.8 9.8 0.001 19.4 0.3 6.8 4 2 2 6 6 6 2 HEAT repeats HEAT PF02985.22 EFE42347.1 - 4.7e-13 48.2 15.5 0.24 11.8 0.2 8.8 10 0 0 10 10 10 4 HEAT repeat Adaptin_N PF01602.20 EFE42347.1 - 1.9e-07 30.0 8.8 0.00031 19.4 2.8 3.7 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 EFE42347.1 - 4.3e-05 23.1 3.8 0.1 12.1 0.0 3.3 2 1 1 3 3 3 2 Armadillo-like V-ATPase_H_N PF03224.14 EFE42347.1 - 0.00027 20.3 2.2 0.0014 17.9 0.5 2.7 2 1 0 3 3 3 1 V-ATPase subunit H KAP PF05804.12 EFE42347.1 - 0.00037 18.8 0.2 0.00061 18.1 0.2 1.5 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) IFRD PF05004.13 EFE42347.1 - 0.0019 17.4 2.5 2.2 7.3 0.1 4.0 2 2 2 4 4 4 1 Interferon-related developmental regulator (IFRD) V-ATPase_H_C PF11698.8 EFE42347.1 - 0.0022 18.1 1.2 30 4.8 0.0 4.6 3 1 3 6 6 6 0 V-ATPase subunit H Atx10homo_assoc PF09759.9 EFE42347.1 - 0.0052 16.8 2.4 1.7 8.7 0.0 4.3 4 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain HEAT_PBS PF03130.16 EFE42347.1 - 0.01 16.4 3.3 1.3 9.9 0.5 5.0 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat EXOSC1 PF10447.9 EFE42348.1 - 9.9e-28 96.9 3.2 1.4e-27 96.4 3.2 1.3 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EFE42348.1 - 2.6e-12 46.3 0.1 4.5e-12 45.6 0.1 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region PCB_OB PF17092.5 EFE42348.1 - 0.06 14.1 1.3 0.3 11.8 1.1 2.1 1 1 0 1 1 1 0 Penicillin-binding protein OB-like domain GTP_EFTU PF00009.27 EFE42349.1 - 4.5e-50 169.9 0.0 8.1e-50 169.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFE42349.1 - 7.9e-08 32.6 0.0 2.5e-07 31.0 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFE42349.1 - 3.7e-07 30.1 0.0 9.5e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EFE42349.1 - 7.6e-07 29.1 0.0 2.1e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EFE42349.1 - 0.00018 21.2 0.0 0.0016 18.2 0.0 2.5 1 1 0 1 1 1 1 Elongation factor G, domain IV NAD_kinase PF01513.21 EFE42350.1 - 1.8e-74 250.6 0.0 2.3e-74 250.2 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase Las1 PF04031.13 EFE42353.1 - 5.2e-17 62.4 0.3 8.9e-17 61.6 0.3 1.4 1 0 0 1 1 1 1 Las1-like HAGH_C PF16123.5 EFE42354.1 - 3.7e-20 72.2 0.4 5.5e-20 71.7 0.4 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EFE42354.1 - 1.7e-09 38.0 3.1 2.4e-08 34.2 3.1 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BcrAD_BadFG PF01869.20 EFE42354.1 - 0.059 12.9 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Lactamase_B_2 PF12706.7 EFE42354.1 - 0.12 11.8 0.3 0.25 10.8 0.2 1.6 1 1 0 1 1 1 0 Beta-lactamase superfamily domain SWIB PF02201.18 EFE42354.1 - 0.14 12.1 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 SWIB/MDM2 domain Peptidase_S24 PF00717.23 EFE42355.1 - 2.6e-08 33.7 0.1 4e-08 33.1 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like PBP PF01161.20 EFE42356.1 - 2.7e-06 27.7 0.0 4.7e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ABC_tran_Xtn PF12848.7 EFE42356.1 - 4.8 7.3 10.4 0.46 10.5 5.1 2.0 2 0 0 2 2 2 0 ABC transporter Ribosomal_L4 PF00573.22 EFE42357.1 - 1.5e-45 155.2 0.0 1.9e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family ECH_2 PF16113.5 EFE42358.1 - 1e-121 406.5 0.0 1.4e-121 406.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EFE42358.1 - 3.3e-22 79.0 0.1 3.9e-21 75.5 0.0 2.3 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase MBD_C PF14048.6 EFE42358.1 - 0.18 12.6 0.1 9.8 7.0 0.0 2.3 2 0 0 2 2 2 0 C-terminal domain of methyl-CpG binding protein 2 and 3 RhoGAP PF00620.27 EFE42359.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 RhoGAP domain CBS PF00571.28 EFE42360.1 - 4.8e-19 68.6 7.6 7.5e-09 35.9 0.6 3.1 3 0 0 3 3 3 3 CBS domain CRAL_TRIO PF00650.20 EFE42361.1 - 1.8e-36 125.3 0.0 2.5e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFE42361.1 - 5.7e-14 52.1 0.0 1.4e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFE42361.1 - 0.0005 20.2 0.0 0.00073 19.7 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Pol_alpha_B_N PF08418.10 EFE42362.1 - 2.8e-24 86.5 0.0 3.1e-24 86.3 0.0 1.0 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EFE42363.1 - 1.8e-34 119.0 0.0 2.4e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.10 EFE42363.1 - 1.9e-29 103.3 1.5 2.6e-29 102.9 1.5 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal Metallophos_3 PF14582.6 EFE42363.1 - 0.13 11.6 0.0 17 4.6 0.0 2.2 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily Apc13p PF05839.11 EFE42364.1 - 1.9e-17 63.2 0.1 2.3e-17 63.0 0.1 1.2 1 0 0 1 1 1 1 Apc13p protein IF-2B PF01008.17 EFE42365.1 - 2e-64 217.5 0.1 2.8e-64 217.1 0.1 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Plasmodium_Vir PF05795.11 EFE42365.1 - 9.7 5.5 5.1 15 4.9 5.1 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Kinesin PF00225.23 EFE42366.1 - 4.2e-111 371.1 0.0 7.5e-111 370.2 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFE42366.1 - 1.2e-25 90.2 0.4 3e-25 88.9 0.0 1.8 2 0 0 2 2 2 1 Microtubule binding DUF1460 PF07313.12 EFE42366.1 - 0.045 13.1 1.3 0.09 12.2 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1460) Spc7 PF08317.11 EFE42366.1 - 0.11 11.3 10.8 0.21 10.4 10.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5094 PF17015.5 EFE42366.1 - 0.11 12.6 5.9 0.23 11.5 5.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) FUSC PF04632.12 EFE42366.1 - 0.54 8.7 3.7 0.31 9.5 1.1 1.7 1 1 1 2 2 2 0 Fusaric acid resistance protein family DUF1043 PF06295.12 EFE42366.1 - 0.84 9.6 6.4 2 8.4 6.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) BPL_N PF09825.9 EFE42366.1 - 1.2 8.2 3.4 2.5 7.1 3.4 1.5 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF87 PF01935.17 EFE42366.1 - 1.4 8.9 9.5 0.88 9.6 0.1 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain YabA PF06156.13 EFE42366.1 - 4.4 8.0 13.6 37 5.0 7.7 3.1 3 1 0 3 3 3 0 Initiation control protein YabA PUL PF08324.11 EFE42367.1 - 1.3e-57 195.1 1.3 2.1e-57 194.5 1.3 1.3 1 0 0 1 1 1 1 PUL domain Thioredoxin PF00085.20 EFE42367.1 - 9.2e-15 54.5 0.0 1.7e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFE42367.1 - 3.3e-05 24.3 0.3 0.00025 21.4 0.3 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 EFE42367.1 - 3.3e-05 23.8 0.0 5.3e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 EFE42367.1 - 0.0052 16.2 0.0 0.0081 15.6 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 EFE42367.1 - 0.01 15.9 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain AhpC-TSA PF00578.21 EFE42367.1 - 0.018 15.0 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 EFE42367.1 - 0.055 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Redoxin DSBA PF01323.20 EFE42367.1 - 0.11 12.3 0.0 0.42 10.4 0.0 1.9 1 1 1 2 2 2 0 DSBA-like thioredoxin domain EF-hand_9 PF14658.6 EFE42368.1 - 0.0016 18.7 0.0 2.6 8.5 0.0 2.5 3 0 0 3 3 3 2 EF-hand domain Dak2 PF02734.17 EFE42368.1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.5 1 1 0 1 1 1 0 DAK2 domain zinc_ribbon_10 PF10058.9 EFE42368.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein UCH PF00443.29 EFE42369.1 - 1.7e-30 106.4 0.0 9e-30 104.0 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE42369.1 - 2.2e-07 30.8 1.5 1.5e-05 24.8 1.5 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Alb1 PF09135.11 EFE42370.1 - 1.8e-30 105.9 11.5 3.2e-30 105.1 11.5 1.4 1 0 0 1 1 1 1 Alb1 MmgE_PrpD PF03972.14 EFE42370.1 - 0.24 9.9 2.6 0.29 9.6 2.6 1.1 1 0 0 1 1 1 0 MmgE/PrpD family Vps16_C PF04840.12 EFE42371.1 - 5.9e-70 235.8 0.3 8.8e-70 235.3 0.3 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 EFE42371.1 - 5.6e-55 186.8 0.0 3e-53 181.1 0.0 2.3 1 1 0 1 1 1 1 Vps16, N-terminal region DCB PF16213.5 EFE42372.1 - 0.098 12.3 0.5 0.14 11.8 0.5 1.2 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 Bestrophin PF01062.21 EFE42374.1 - 1.5e-56 191.9 0.0 2.1e-56 191.5 0.0 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel FHA PF00498.26 EFE42375.1 - 2.5e-14 53.4 0.0 5.3e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EFE42375.1 - 8.6e-09 35.0 2.5 1.1e-05 25.1 0.7 2.5 2 0 0 2 2 2 2 RING-like zinc finger Yop-YscD_cpl PF16697.5 EFE42375.1 - 0.00025 21.3 0.2 0.00081 19.7 0.0 1.9 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_2 PF13639.6 EFE42375.1 - 0.00047 20.4 8.1 0.0014 19.0 4.5 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EFE42375.1 - 0.012 15.5 4.0 0.034 14.0 4.0 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFE42375.1 - 0.025 14.9 5.6 0.082 13.2 5.6 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFE42375.1 - 0.031 14.3 1.3 0.074 13.1 1.3 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.11 EFE42375.1 - 0.42 11.0 4.4 1.3 9.4 4.4 1.8 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.6 EFE42375.1 - 0.9 9.4 9.3 0.22 11.4 4.7 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE42375.1 - 2 8.5 11.7 6.9 6.7 11.8 1.9 1 1 0 1 1 1 0 zinc-RING finger domain CIAPIN1 PF05093.13 EFE42376.1 - 0.03 14.8 0.3 0.072 13.6 0.3 1.6 1 1 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DUF4131 PF13567.6 EFE42377.1 - 0.031 13.9 0.0 0.037 13.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2527 PF10736.9 EFE42378.1 - 0.02 14.7 0.1 0.043 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) DZR PF12773.7 EFE42379.1 - 0.0023 17.9 2.4 1.6 8.8 0.0 2.3 2 0 0 2 2 2 2 Double zinc ribbon zinc_ribbon_2 PF13240.6 EFE42379.1 - 0.048 13.4 4.0 1.4 8.7 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain Apt1 PF10351.9 EFE42379.1 - 2.5 6.9 7.5 4 6.2 7.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain WD40 PF00400.32 EFE42380.1 - 1.3e-19 70.1 14.4 2e-05 25.2 0.0 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE42380.1 - 0.0016 18.7 0.0 0.023 15.0 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE42380.1 - 0.0026 16.5 4.3 0.31 9.6 0.1 3.8 1 1 2 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EFE42380.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain Proteasome PF00227.26 EFE42381.1 - 6e-29 100.9 0.0 6.9e-29 100.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit MF_alpha_N PF05436.11 EFE42382.1 - 0.02 14.8 0.6 0.037 13.9 0.2 1.7 2 0 0 2 2 2 0 Mating factor alpha precursor N-terminus Peptidase_C97 PF05903.14 EFE42382.1 - 0.034 14.0 0.1 0.058 13.2 0.1 1.5 2 0 0 2 2 2 0 PPPDE putative peptidase domain TLD PF07534.16 EFE42383.1 - 8.7e-12 45.4 0.0 1.7e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 TLD UCH PF00443.29 EFE42384.1 - 1.2e-21 77.4 0.1 3.4e-21 75.9 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EFE42384.1 - 4.4e-12 46.1 0.3 7.8e-12 45.4 0.3 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EFE42384.1 - 0.0038 16.9 0.1 0.011 15.3 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 EFE42386.1 - 7.9e-54 178.4 17.5 9.1e-06 26.3 0.0 12.4 11 3 0 11 11 11 9 WD domain, G-beta repeat Utp13 PF08625.11 EFE42386.1 - 1.3e-48 164.5 0.2 2.1e-48 163.8 0.2 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EFE42386.1 - 1.1e-12 48.1 1.3 1.5 9.2 0.0 7.7 5 1 3 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE42386.1 - 0.00013 20.8 13.5 0.66 8.5 1.2 5.8 3 3 3 7 7 7 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFE42386.1 - 0.00017 20.5 2.8 0.44 9.2 0.1 4.8 5 1 1 6 6 6 2 Nup133 N terminal like Ge1_WD40 PF16529.5 EFE42386.1 - 0.018 14.0 3.0 5.7 5.8 0.0 4.6 3 2 2 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein G-patch_2 PF12656.7 EFE42387.1 - 1.5e-24 85.8 0.2 5.6e-24 84.0 0.2 2.1 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 EFE42387.1 - 0.00035 20.4 1.4 0.0008 19.2 0.5 2.1 2 0 0 2 2 2 1 G-patch domain Myb_DNA-bind_6 PF13921.6 EFE42388.1 - 6.4e-17 61.6 0.1 6.4e-17 61.6 0.1 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain HSA PF07529.13 EFE42388.1 - 9.9e-14 51.4 0.2 9.9e-14 51.4 0.2 3.3 3 0 0 3 3 3 1 HSA Myb_DNA-binding PF00249.31 EFE42388.1 - 0.00021 21.4 0.4 0.00056 20.1 0.4 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain WD40 PF00400.32 EFE42389.1 - 6.4e-09 36.3 0.0 3.9 8.5 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EFE42389.1 - 0.0043 15.9 0.2 1.6 7.4 0.0 2.5 2 1 0 2 2 2 2 Nup133 N terminal like CW_7 PF08230.11 EFE42389.1 - 0.018 14.8 0.2 0.036 13.8 0.2 1.4 1 0 0 1 1 1 0 CW_7 repeat FAM176 PF14851.6 EFE42389.1 - 0.34 10.6 2.0 0.91 9.2 0.3 2.2 2 0 0 2 2 2 0 FAM176 family eIF2_C PF09173.11 EFE42390.1 - 2.9e-34 117.2 0.2 7e-34 115.9 0.2 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EFE42390.1 - 5.8e-23 81.4 0.2 4.3e-22 78.6 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFE42390.1 - 5.5e-11 42.7 0.1 1.1e-10 41.7 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 EFE42390.1 - 0.0054 16.7 0.1 0.061 13.2 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFE42390.1 - 0.0062 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase PGA2 PF07543.12 EFE42391.1 - 0.033 14.2 11.4 0.046 13.7 11.4 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 Coilin_N PF15862.5 EFE42391.1 - 3 7.7 9.8 4.5 7.1 9.8 1.3 1 0 0 1 1 1 0 Coilin N-terminus Peptidase_S49_N PF08496.10 EFE42391.1 - 5 7.2 8.9 2.1 8.4 6.7 1.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal NARP1 PF12569.8 EFE42391.1 - 8.4 5.2 12.0 12 4.7 12.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 ABC_export PF16962.5 EFE42391.1 - 8.9 4.6 5.6 11 4.3 5.6 1.0 1 0 0 1 1 1 0 Putative ABC exporter Peptidase_M48_N PF16491.5 EFE42392.1 - 1.1e-66 224.2 9.2 2.6e-66 223.0 9.2 1.7 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EFE42392.1 - 5.5e-44 150.3 0.0 1.1e-43 149.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M48 DUF4538 PF15061.6 EFE42392.1 - 0.016 14.9 1.1 0.042 13.6 1.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Peptidase_M56 PF05569.11 EFE42392.1 - 0.56 9.4 4.2 1.6 7.8 2.1 2.5 2 1 0 2 2 2 0 BlaR1 peptidase M56 MFS_1 PF07690.16 EFE42393.1 - 5e-35 121.1 55.1 2.1e-33 115.7 53.2 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Pox_A14 PF05767.12 EFE42393.1 - 2.2 8.5 7.1 0.77 10.0 1.4 2.9 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 Fungal_trans PF04082.18 EFE42394.1 - 2.7e-16 59.4 0.9 4.5e-16 58.7 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hydrolase_4 PF12146.8 EFE42395.1 - 1.9e-10 40.4 0.0 2.5e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFE42395.1 - 5.4e-10 40.2 0.5 5.4e-10 40.2 0.5 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFE42395.1 - 1.4e-05 24.9 0.3 2e-05 24.4 0.3 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EFE42395.1 - 0.0002 21.3 0.1 0.00031 20.7 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFE42395.1 - 0.00025 20.6 0.1 0.089 12.3 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family AXE1 PF05448.12 EFE42395.1 - 0.13 10.9 0.1 0.25 10.0 0.1 1.4 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Glyc_hyd_38C_2 PF18230.1 EFE42396.1 - 0.11 12.6 0.1 0.38 10.9 0.1 1.8 2 0 0 2 2 2 0 Glycosyl hydrolases family 38 C-terminal sub-domain Ank_2 PF12796.7 EFE42398.1 - 1.6e-47 160.0 0.0 5.9e-13 49.2 0.0 6.0 4 2 1 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE42398.1 - 1.1e-42 143.9 0.7 1.4e-08 35.1 0.1 8.6 5 2 5 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE42398.1 - 6.5e-32 106.0 0.1 0.011 16.2 0.0 11.9 11 0 0 11 11 11 7 Ankyrin repeat Ank PF00023.30 EFE42398.1 - 2.2e-26 91.1 0.4 0.11 13.0 0.1 10.8 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 EFE42398.1 - 3.4e-24 84.6 0.5 0.00075 19.7 0.0 8.1 4 2 4 8 8 8 6 Ankyrin repeats (many copies) NACHT PF05729.12 EFE42398.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Peptidase_M16_C PF05193.21 EFE42399.1 - 1.2e-10 41.7 0.0 1.1e-09 38.6 0.0 2.7 2 1 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFE42399.1 - 1.1e-07 31.9 0.0 2.7e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) RQC PF09382.10 EFE42399.1 - 0.06 13.1 0.3 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 RQC domain M16C_assoc PF08367.11 EFE42399.1 - 0.69 9.0 2.7 12 4.9 0.0 2.4 2 0 0 2 2 2 0 Peptidase M16C associated GCIP PF13324.6 EFE42399.1 - 3.6 7.1 8.7 8.3 5.9 8.7 1.6 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Zw10 PF06248.13 EFE42400.1 - 2e-11 43.2 1.9 4.1e-11 42.2 1.9 1.5 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 EFE42400.1 - 2e-07 30.9 0.1 4.4e-07 29.8 0.1 1.5 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal IFT46_B_C PF12317.8 EFE42400.1 - 0.075 12.8 1.8 0.17 11.6 1.8 1.6 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal NLE PF08154.12 EFE42401.1 - 9.9e-17 61.2 0.1 1.8e-16 60.4 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 EFE42401.1 - 2.4e-16 59.8 21.7 4e-07 30.6 0.2 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat Ribosomal_S13 PF00416.22 EFE42402.1 - 3.7e-12 46.8 0.2 4.4e-12 46.5 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Pro_isomerase PF00160.21 EFE42403.1 - 2.1e-40 138.6 0.6 2.9e-40 138.1 0.6 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD COesterase PF00135.28 EFE42404.1 - 2e-101 340.4 0.0 2.6e-101 340.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE42404.1 - 4.8e-05 23.3 0.0 0.00011 22.2 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFE42404.1 - 0.0035 16.8 0.0 0.0065 16.0 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Fungal_trans_2 PF11951.8 EFE42405.1 - 2.9e-06 26.4 0.1 1.8e-05 23.7 0.0 2.1 2 1 0 2 2 2 1 Fungal specific transcription factor domain DEAD PF00270.29 EFE42407.1 - 7.7e-48 162.6 0.0 3e-47 160.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE42407.1 - 3.4e-32 111.1 0.0 7.6e-32 110.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE42407.1 - 0.012 15.7 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFE42407.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 EFE42407.1 - 0.22 10.7 0.0 0.35 10.0 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase NPR3 PF03666.13 EFE42408.1 - 1.8 7.3 23.6 0.76 8.5 8.7 2.7 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 INSIG PF07281.12 EFE42409.1 - 6.6e-74 248.1 4.9 1.1e-73 247.4 4.9 1.4 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) Clathrin PF00637.20 EFE42410.1 - 2e-196 643.8 34.8 5.3e-34 117.1 0.7 7.4 7 0 0 7 7 7 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EFE42410.1 - 6.6e-30 102.8 1.3 2e-29 101.3 0.2 2.5 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 EFE42410.1 - 6.9e-30 101.9 1.1 1.6e-05 24.9 0.0 5.8 5 0 0 5 5 5 5 Clathrin propeller repeat TPR_14 PF13428.6 EFE42410.1 - 3.2e-06 27.5 4.4 0.36 11.8 0.2 7.6 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFE42410.1 - 0.0064 16.6 1.0 3.3 8.2 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat Clathrin-link PF09268.10 EFE42410.1 - 0.01 15.2 0.0 0.022 14.1 0.0 1.6 1 0 0 1 1 1 0 Clathrin, heavy-chain linker VapB_antitoxin PF09957.9 EFE42410.1 - 0.09 12.7 0.6 0.36 10.8 0.0 2.4 3 0 0 3 3 3 0 Bacterial antitoxin of type II TA system, VapB TPR_7 PF13176.6 EFE42410.1 - 0.2 11.8 7.6 79 3.6 0.1 6.8 8 0 0 8 8 8 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EFE42410.1 - 0.33 9.9 6.7 2 7.3 0.3 3.3 3 0 0 3 3 3 0 Coatomer WD associated region DUF1400 PF07176.11 EFE42410.1 - 0.97 9.7 3.6 12 6.2 0.0 4.1 4 1 0 4 4 4 0 Alpha/beta hydrolase of unknown function (DUF1400) TPR_19 PF14559.6 EFE42410.1 - 1.2 9.6 7.7 58 4.3 0.0 5.1 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFE42410.1 - 1.4 8.9 4.2 36 4.4 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat PRC2_HTH_1 PF18118.1 EFE42411.1 - 0.038 14.8 5.3 0.048 14.5 5.3 1.2 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Ribosomal_S17 PF00366.20 EFE42411.1 - 1.2 9.3 7.9 1.4 9.0 6.8 1.7 1 1 0 1 1 1 0 Ribosomal protein S17 CPSase_L_D2 PF02786.17 EFE42412.1 - 1.3e-80 269.9 0.1 2.1e-80 269.2 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EFE42412.1 - 3.4e-70 235.8 0.0 5.7e-70 235.1 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EFE42412.1 - 1.7e-39 134.8 0.1 3.4e-39 133.8 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFE42412.1 - 1.2e-31 109.0 0.0 4e-31 107.3 0.0 1.9 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EFE42412.1 - 1.8e-23 83.4 0.0 3.9e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 EFE42412.1 - 4.4e-17 61.7 4.5 4.6e-17 61.6 2.9 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EFE42412.1 - 5.7e-09 35.7 1.9 0.0001 22.1 0.1 3.2 2 1 1 3 3 3 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EFE42412.1 - 7.9e-09 35.3 0.0 1.5e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EFE42412.1 - 5.8e-07 29.2 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EFE42412.1 - 0.00012 22.1 0.0 0.00029 20.9 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EFE42412.1 - 0.00047 19.8 0.0 0.00098 18.8 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_D23 PF16576.5 EFE42412.1 - 0.0016 17.7 0.1 0.075 12.2 0.1 2.5 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 EFE42412.1 - 0.02 15.6 0.1 7.6 7.3 0.1 3.1 3 0 0 3 3 3 0 HlyD family secretion protein ATP-grasp_4 PF13535.6 EFE42412.1 - 0.024 14.2 0.0 0.36 10.4 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain DUF2118 PF09891.9 EFE42412.1 - 0.037 14.0 0.1 0.089 12.8 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) Ribosomal_L5_C PF00673.21 EFE42413.1 - 3.4e-22 78.4 0.0 4.9e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EFE42413.1 - 2e-20 72.8 0.0 7.6e-20 71.0 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L5 LSM PF01423.22 EFE42414.1 - 1.4e-06 27.8 0.0 1.8e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 LSM domain Aa_trans PF01490.18 EFE42416.1 - 7.4e-85 285.1 34.8 8.9e-85 284.9 34.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TM_PBP2_N PF16296.5 EFE42416.1 - 0.023 14.8 0.0 0.066 13.4 0.0 1.8 1 0 0 1 1 1 0 N-terminal of TM subunit in PBP-dependent ABC transporters Glycophorin_A PF01102.18 EFE42416.1 - 0.24 11.7 3.0 2.3 8.5 0.8 2.7 2 0 0 2 2 2 0 Glycophorin A AA_permease PF00324.21 EFE42417.1 - 8.6e-54 182.9 33.0 1.1e-53 182.6 33.0 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EFE42417.1 - 5.4e-23 81.7 0.0 3.4e-07 29.6 0.0 3.4 3 0 0 3 3 3 3 Solute carrier family 12 GHMP_kinases_N PF00288.26 EFE42418.1 - 3e-16 59.4 0.3 2.9e-15 56.3 0.0 2.3 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFE42418.1 - 1.8e-09 37.8 0.0 4.4e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EFE42418.1 - 0.0004 19.9 0.0 0.0008 18.9 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature PPTA PF01239.22 EFE42419.1 - 0.00011 21.8 0.0 0.00019 21.1 0.0 1.4 1 0 0 1 1 1 1 Protein prenyltransferase alpha subunit repeat PPTA PF01239.22 EFE42420.1 - 3.3e-23 80.6 6.0 1.1e-09 37.7 2.0 3.5 3 0 0 3 3 3 3 Protein prenyltransferase alpha subunit repeat PALP PF00291.25 EFE42421.1 - 6.5e-55 186.6 0.3 2.9e-52 177.9 0.1 2.6 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme tRNA-synt_1g PF09334.11 EFE42422.1 - 1.7e-54 185.1 0.0 2.3e-54 184.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EFE42422.1 - 1.3e-13 50.2 0.0 6.8e-12 44.4 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EFE42422.1 - 0.024 14.0 0.0 0.054 12.8 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Ribosomal_L38e PF01781.18 EFE42423.1 - 1.1e-31 108.7 1.9 1.3e-31 108.5 1.9 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Acetyltransf_3 PF13302.7 EFE42424.1 - 5.8e-16 59.4 0.0 8.9e-15 55.6 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE42424.1 - 9.4e-05 22.3 0.2 0.043 13.8 0.0 2.5 1 1 0 2 2 2 2 FR47-like protein Acetyltransf_4 PF13420.7 EFE42424.1 - 0.0032 17.6 0.1 0.011 15.9 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DNA_pol_E_B PF04042.16 EFE42425.1 - 3.8e-43 147.3 0.0 9.3e-43 146.0 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EFE42425.1 - 3.3e-37 127.5 0.0 5.2e-37 126.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain NMO PF03060.15 EFE42426.1 - 1.3e-53 182.5 0.3 1.7e-53 182.2 0.3 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EFE42426.1 - 3.2e-07 29.7 0.4 2.7e-06 26.6 0.4 2.1 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EFE42426.1 - 0.0013 17.8 3.3 0.0022 17.1 3.3 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase PEP_hydrolase PF09370.10 EFE42426.1 - 0.11 11.6 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like Taxilin PF09728.9 EFE42427.1 - 5.3e-89 298.4 51.7 5.3e-89 298.4 51.7 1.7 2 1 0 2 2 2 1 Myosin-like coiled-coil protein OmpH PF03938.14 EFE42427.1 - 0.013 15.9 5.1 0.013 15.9 5.1 4.2 1 1 3 4 4 4 0 Outer membrane protein (OmpH-like) DUF948 PF06103.11 EFE42427.1 - 0.088 13.1 18.3 0.26 11.6 0.2 4.7 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.8 EFE42427.1 - 0.11 12.7 50.4 0.24 11.6 2.4 4.3 2 2 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 EFE42427.1 - 0.8 9.0 44.2 0.22 10.8 7.9 4.1 1 1 2 4 4 4 0 Protein of unknown function (DUF3450) DUF3675 PF12428.8 EFE42427.1 - 1.1 9.8 3.6 9.5 6.8 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3675) GOLGA2L5 PF15070.6 EFE42427.1 - 1.5 7.4 42.4 0.32 9.6 32.0 2.1 1 1 1 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 COG2 PF06148.11 EFE42427.1 - 2.4 8.3 26.0 1.1 9.3 0.4 4.1 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 UPF0242 PF06785.11 EFE42427.1 - 2.7 8.1 54.4 3.9 7.5 6.3 4.5 1 1 2 3 3 2 0 Uncharacterised protein family (UPF0242) N-terminus Laminin_II PF06009.12 EFE42427.1 - 3.1 7.8 33.3 0.86 9.6 4.3 4.2 1 1 2 4 4 4 0 Laminin Domain II DHR10 PF18595.1 EFE42427.1 - 4.2 7.5 45.8 1.2 9.2 1.7 4.8 3 1 1 4 4 4 0 Designed helical repeat protein 10 domain CENP-F_leu_zip PF10473.9 EFE42427.1 - 4.6 7.3 53.8 0.19 11.8 5.3 4.0 1 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.8 EFE42427.1 - 6.8 4.1 48.7 8.2 3.8 44.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) NCD2 PF04905.13 EFE42427.1 - 7.4 6.6 14.7 0.74 9.8 1.8 3.3 2 1 1 3 3 3 0 NAB conserved region 2 (NCD2) M16C_assoc PF08367.11 EFE42428.1 - 8e-74 247.9 0.1 1.3e-73 247.2 0.1 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EFE42428.1 - 5.5e-25 88.4 0.0 1.2e-16 61.3 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFE42428.1 - 3.6e-10 40.0 0.0 1.8e-09 37.7 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) PgaD PF13994.6 EFE42430.1 - 0.0051 16.9 2.3 0.0051 16.9 2.3 2.1 1 1 2 3 3 3 1 PgaD-like protein Serinc PF03348.15 EFE42430.1 - 0.0055 15.7 0.6 0.0062 15.5 0.6 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) SARAF PF06682.12 EFE42430.1 - 0.0077 15.9 0.4 0.009 15.7 0.4 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis V_ATPase_I PF01496.19 EFE42430.1 - 0.047 11.6 0.9 0.051 11.5 0.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OSTbeta PF15048.6 EFE42430.1 - 0.05 13.7 4.9 0.069 13.3 4.4 1.4 1 1 0 1 1 1 0 Organic solute transporter subunit beta protein FHIPEP PF00771.20 EFE42430.1 - 0.072 11.5 1.1 0.079 11.4 1.1 1.1 1 0 0 1 1 1 0 FHIPEP family DUF5308 PF17233.2 EFE42430.1 - 0.094 12.9 4.8 0.17 12.1 4.8 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5308) RR_TM4-6 PF06459.12 EFE42430.1 - 0.13 12.1 11.9 0.16 11.8 11.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 OATP PF03137.20 EFE42430.1 - 0.16 10.2 0.2 0.17 10.1 0.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Connexin PF00029.19 EFE42430.1 - 0.17 11.6 5.9 0.17 11.6 5.0 1.4 1 1 0 1 1 1 0 Connexin DUF4834 PF16118.5 EFE42430.1 - 0.2 12.6 3.9 0.6 11.1 3.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Protocadherin PF08374.11 EFE42430.1 - 0.25 11.3 5.7 0.35 10.8 5.7 1.2 1 0 0 1 1 1 0 Protocadherin Miga PF10265.9 EFE42430.1 - 0.31 10.0 4.3 0.37 9.7 4.3 1.1 1 0 0 1 1 1 0 Mitoguardin AP3D1 PF06375.11 EFE42430.1 - 0.33 11.2 15.9 0.091 13.0 12.9 1.7 1 1 1 2 2 2 0 AP-3 complex subunit delta-1 CLN3 PF02487.17 EFE42430.1 - 0.37 9.8 0.6 0.43 9.6 0.6 1.1 1 0 0 1 1 1 0 CLN3 protein NEMP PF10225.9 EFE42430.1 - 0.39 10.3 0.7 0.49 10.0 0.7 1.1 1 0 0 1 1 1 0 NEMP family EphA2_TM PF14575.6 EFE42430.1 - 0.94 10.4 3.7 3.2 8.7 3.7 2.0 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Presenilin PF01080.17 EFE42430.1 - 1.3 7.7 6.8 1.5 7.5 6.8 1.3 1 0 0 1 1 1 0 Presenilin Draxin PF15550.6 EFE42430.1 - 1.4 8.7 12.3 1.7 8.5 12.3 1.1 1 0 0 1 1 1 0 Draxin Neur_chan_memb PF02932.16 EFE42430.1 - 2.7 8.0 3.7 3 7.8 3.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AIF_C PF14721.6 EFE42430.1 - 3.1 8.1 6.5 2.2 8.6 4.8 1.7 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TMEM214 PF10151.9 EFE42430.1 - 4.5 5.6 6.4 4.6 5.6 6.4 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Sec62 PF03839.16 EFE42430.1 - 4.9 6.6 8.2 7 6.1 8.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Rtf2 PF04641.12 EFE42430.1 - 5.9 6.2 13.2 8.8 5.6 13.2 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger NPR3 PF03666.13 EFE42430.1 - 8.2 5.1 8.9 11 4.6 8.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Cation_efflux PF01545.21 EFE42431.1 - 1.5e-32 113.0 0.8 3.2e-32 111.9 0.8 1.5 1 1 0 1 1 1 1 Cation efflux family Peptidase_M66 PF10462.9 EFE42431.1 - 7.6 5.4 10.5 13 4.6 10.5 1.3 1 0 0 1 1 1 0 Peptidase M66 GP67 PF17634.2 EFE42433.1 - 0.03 14.7 4.6 0.03 14.7 4.6 2.3 2 0 0 2 2 2 0 Gene product 67 CPSF100_C PF13299.6 EFE42433.1 - 0.045 13.9 1.6 0.075 13.2 0.2 1.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RPA43_OB PF17875.1 EFE42433.1 - 0.11 13.2 2.9 0.23 12.1 0.2 2.0 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Ferlin_C PF16165.5 EFE42433.1 - 0.16 11.9 1.0 0.27 11.2 1.0 1.4 1 0 0 1 1 1 0 Ferlin C-terminus TRAP_alpha PF03896.16 EFE42433.1 - 0.41 9.8 3.5 0.081 12.1 0.3 1.5 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 EFE42433.1 - 0.43 10.3 3.5 0.14 11.9 0.7 1.6 1 1 1 2 2 2 0 Connexin Coilin_N PF15862.5 EFE42433.1 - 0.56 10.0 8.1 0.063 13.1 2.3 1.9 2 0 0 2 2 2 0 Coilin N-terminus TFB6 PF17110.5 EFE42433.1 - 0.94 9.2 5.8 0.4 10.4 1.7 1.9 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH CobT PF06213.12 EFE42433.1 - 1.2 8.5 11.7 0.066 12.6 2.9 2.0 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 EFE42433.1 - 1.2 8.4 10.6 3.8 6.7 6.6 2.1 2 0 0 2 2 2 0 NOA36 protein GCIP PF13324.6 EFE42433.1 - 2 8.0 6.4 0.073 12.7 0.7 1.6 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting GEN1_C PF18380.1 EFE42433.1 - 2.4 9.1 8.9 0.83 10.6 3.3 2.0 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain PTPRCAP PF15713.5 EFE42433.1 - 3.2 8.0 14.3 11 6.3 9.1 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 EFE42433.1 - 3.4 5.8 11.4 0.28 9.4 4.2 1.9 2 0 0 2 2 2 0 CDC45-like protein DUF4611 PF15387.6 EFE42433.1 - 3.5 7.9 15.3 0.82 9.9 7.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF913 PF06025.12 EFE42433.1 - 4.3 6.2 5.0 0.89 8.5 1.2 1.6 1 1 1 2 2 2 0 Domain of Unknown Function (DUF913) RNA_pol_Rpc4 PF05132.14 EFE42433.1 - 5.2 7.5 7.4 0.89 10.0 1.3 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 FAM176 PF14851.6 EFE42433.1 - 6.9 6.3 12.9 1.6 8.4 5.4 2.1 2 0 0 2 2 2 0 FAM176 family DUF5549 PF17703.1 EFE42435.1 - 0.93 9.1 7.2 1 9.0 7.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5549) FancD2 PF14631.6 EFE42435.1 - 2.2 5.5 7.5 2.3 5.5 7.5 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Myb_DNA-binding PF00249.31 EFE42436.1 - 2.4e-26 91.6 1.8 9e-15 54.6 0.1 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFE42436.1 - 3.1e-18 65.8 7.3 5.5e-14 52.1 0.1 3.3 2 1 1 3 3 3 2 Myb-like DNA-binding domain HTH_23 PF13384.6 EFE42436.1 - 0.14 12.0 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DUF2774 PF11242.8 EFE42436.1 - 0.15 12.3 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) RAB3GAP2_N PF14655.6 EFE42436.1 - 0.19 10.9 2.0 0.16 11.2 0.4 1.6 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Myb_DNA-bind_4 PF13837.6 EFE42436.1 - 0.47 10.9 0.0 0.47 10.9 0.0 2.8 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain ABC_membrane PF00664.23 EFE42437.1 - 6.6e-31 108.0 21.3 5.8e-21 75.3 6.4 2.7 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE42437.1 - 1.1e-28 100.5 0.0 1e-15 58.4 0.0 3.7 3 1 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EFE42437.1 - 2.6e-08 33.6 0.0 0.00057 19.4 0.0 3.5 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFE42437.1 - 0.04 13.8 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase SbcCD_C PF13558.6 EFE42437.1 - 0.047 13.9 0.0 32 4.9 0.0 3.7 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 EFE42437.1 - 0.05 13.9 0.1 0.39 11.0 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EFE42437.1 - 0.073 12.8 0.0 0.7 9.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFE42437.1 - 0.084 13.4 0.1 0.19 12.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EFE42437.1 - 0.12 12.1 0.2 35 4.1 0.0 3.4 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Mucin PF01456.17 EFE42437.1 - 5.3 7.0 5.2 0.63 10.0 0.4 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein Cu-oxidase_3 PF07732.15 EFE42438.1 - 1.3e-11 44.5 0.7 6.6e-08 32.6 0.3 2.6 2 1 1 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFE42438.1 - 2.2e-07 30.7 0.0 0.0033 17.2 0.0 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EFE42438.1 - 0.0077 16.4 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Multicopper oxidase NCBP3 PF10309.9 EFE42439.1 - 5e-24 83.9 0.1 9.5e-24 83.0 0.1 1.5 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 ATP-synt_DE_N PF02823.16 EFE42440.1 - 4.2e-12 45.8 0.1 9e-11 41.5 0.0 2.1 2 0 0 2 2 2 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Corona_nucleoca PF00937.18 EFE42441.1 - 0.067 12.2 6.3 0.17 10.9 6.3 1.6 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Cytochrom_B561 PF03188.16 EFE42441.1 - 3.8 7.6 8.8 0.31 11.2 3.5 2.0 2 1 0 2 2 2 0 Eukaryotic cytochrome b561 DUF3180 PF11377.8 EFE42441.1 - 8.6 6.5 8.8 0.24 11.6 0.8 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3180) APH PF01636.23 EFE42442.1 - 1.4e-16 61.2 0.0 1.6e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFE42442.1 - 0.0055 16.1 0.0 0.008 15.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MetallophosN PF16371.5 EFE42442.1 - 0.086 13.1 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 N terminal of Calcineurin-like phosphoesterase zf-H2C2_2 PF13465.6 EFE42445.1 - 0.12 12.8 13.8 3.6 8.2 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger double domain SelK_SelG PF10961.8 EFE42445.1 - 0.4 11.3 12.6 0.23 12.1 6.8 3.2 3 0 0 3 3 3 0 Selenoprotein SelK_SelG PQ-loop PF04193.14 EFE42446.1 - 2.4e-29 100.9 17.0 9.1e-18 63.8 1.3 2.9 3 0 0 3 3 3 2 PQ loop repeat DUF3429 PF11911.8 EFE42446.1 - 0.013 15.8 3.1 0.02 15.2 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3429) ERGIC_N PF13850.6 EFE42446.1 - 0.12 12.7 0.6 0.79 10.1 0.0 2.5 3 0 0 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) SPATA9 PF15824.5 EFE42446.1 - 0.2 10.9 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated protein 9 Phos_pyr_kin PF08543.12 EFE42447.1 - 1.8e-11 43.9 0.0 3.3e-11 43.0 0.0 1.5 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EFE42447.1 - 4.2e-07 29.6 0.0 1.2e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 pfkB family carbohydrate kinase BON PF04972.17 EFE42447.1 - 0.069 13.5 1.1 1.1 9.6 0.0 2.5 2 0 0 2 2 2 0 BON domain dUTPase PF00692.19 EFE42448.1 - 2.5e-33 114.5 0.0 3.5e-33 114.0 0.0 1.2 1 0 0 1 1 1 1 dUTPase DCD PF06559.11 EFE42448.1 - 0.2 10.4 0.0 0.28 9.9 0.0 1.1 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) ADIP PF11559.8 EFE42449.1 - 7.1e-34 117.1 16.9 2.2e-22 79.8 13.4 3.3 3 0 0 3 3 3 2 Afadin- and alpha -actinin-Binding TTRAP PF14203.6 EFE42449.1 - 0.12 12.4 0.3 0.52 10.3 0.3 2.1 1 0 0 1 1 1 0 Putative tranposon-transfer assisting protein DUF724 PF05266.14 EFE42449.1 - 0.18 11.6 8.3 0.19 11.5 5.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Golgin_A5 PF09787.9 EFE42449.1 - 0.45 9.9 18.4 0.026 14.0 11.0 2.3 2 1 0 2 2 2 0 Golgin subfamily A member 5 DUF641 PF04859.12 EFE42449.1 - 0.88 9.9 11.9 92 3.4 8.5 3.5 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) KxDL PF10241.9 EFE42449.1 - 1.1 9.5 10.4 0.19 12.0 5.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein HAUS6_N PF14661.6 EFE42449.1 - 2.4 7.7 6.4 6.6 6.2 6.4 1.7 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Troponin PF00992.20 EFE42449.1 - 3.9 7.8 14.8 0.54 10.5 9.8 2.1 2 0 0 2 2 2 0 Troponin KASH_CCD PF14662.6 EFE42449.1 - 6.4 6.6 16.4 0.24 11.2 9.0 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH TRAF_BIRC3_bd PF16673.5 EFE42449.1 - 6.5 6.6 8.1 0.91 9.4 3.2 2.3 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain PKcGMP_CC PF16808.5 EFE42449.1 - 7.2 6.6 7.4 52 3.8 0.6 3.7 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase AKNA PF12443.8 EFE42449.1 - 7.3 7.3 9.7 5.4 7.7 4.0 3.6 3 1 1 4 4 4 0 AT-hook-containing transcription factor RasGAP_C PF03836.15 EFE42449.1 - 7.5 6.7 9.7 5.4 7.2 1.5 2.8 1 1 1 2 2 2 0 RasGAP C-terminus Fib_alpha PF08702.10 EFE42449.1 - 8 6.6 10.2 2.8 8.1 5.8 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SAM_2 PF07647.17 EFE42450.1 - 1.8e-07 31.2 0.1 3.7e-07 30.2 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFE42450.1 - 0.0029 18.0 0.1 0.0068 16.8 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4508 PF14969.6 EFE42450.1 - 0.035 14.4 0.4 0.13 12.5 0.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) DnaJ PF00226.31 EFE42452.1 - 2.3e-10 40.4 0.1 1.7e-09 37.7 0.1 2.3 2 0 0 2 2 2 1 DnaJ domain SEEEED PF14797.6 EFE42452.1 - 2.4 8.4 10.9 0.03 14.5 2.9 1.8 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex CDH-cyt PF16010.5 EFE42453.1 - 0.06 13.0 0.1 0.098 12.3 0.1 1.3 1 0 0 1 1 1 0 Cytochrome domain of cellobiose dehydrogenase Cation_ATPase_C PF00689.21 EFE42453.1 - 2 8.1 23.9 1.4 8.6 3.9 2.3 1 1 1 2 2 2 0 Cation transporting ATPase, C-terminus ADP_ribosyl_GH PF03747.14 EFE42454.1 - 3.6e-50 171.3 0.0 4.8e-50 170.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase BcrAD_BadFG PF01869.20 EFE42455.1 - 2.8e-09 36.9 0.0 5.5e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family SIS_2 PF13580.6 EFE42455.1 - 0.0031 17.5 0.0 0.0068 16.4 0.0 1.6 1 0 0 1 1 1 1 SIS domain SIS PF01380.22 EFE42455.1 - 0.0049 16.7 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 SIS domain MFS_1 PF07690.16 EFE42456.1 - 1e-10 41.1 40.3 1e-10 41.1 40.3 2.2 1 1 2 3 3 3 1 Major Facilitator Superfamily UNC-93 PF05978.16 EFE42456.1 - 1.2e-06 28.3 7.7 1.2e-06 28.3 7.7 3.7 2 2 1 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EFE42457.1 - 3.5e-33 115.0 27.4 3.5e-33 115.0 27.4 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE42457.1 - 5.5e-10 38.7 9.4 5.5e-10 38.7 9.4 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter DUF1746 PF08508.10 EFE42457.1 - 0.21 11.9 2.6 0.29 11.5 0.0 2.5 3 0 0 3 3 3 0 Fungal domain of unknown function (DUF1746) CFEM PF05730.11 EFE42458.1 - 3e-09 36.8 13.4 4.8e-09 36.2 13.4 1.3 1 0 0 1 1 1 1 CFEM domain Ilm1 PF10311.9 EFE42460.1 - 5e-60 201.9 0.4 6.4e-60 201.6 0.4 1.1 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 DUF4770 PF15994.5 EFE42460.1 - 0.058 13.6 0.1 0.094 13.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF5357 PF17310.2 EFE42460.1 - 1.1 7.8 4.3 8.3 4.9 4.3 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF5357) LRRFIP PF09738.9 EFE42460.1 - 2.6 7.4 7.1 4.5 6.6 7.1 1.3 1 0 0 1 1 1 0 LRRFIP family Prenyltrans PF00432.21 EFE42461.1 - 1.1e-14 53.9 18.5 2.1e-05 24.2 0.1 6.4 7 0 0 7 7 7 3 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EFE42461.1 - 0.037 13.1 0.0 0.12 11.4 0.0 1.7 1 1 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain WD-3 PF09765.9 EFE42461.1 - 0.17 11.2 0.0 0.43 9.9 0.0 1.5 2 0 0 2 2 2 0 WD-repeat region SBE2 PF17076.5 EFE42461.1 - 0.18 10.0 0.0 0.25 9.5 0.0 1.1 1 0 0 1 1 1 0 SBE2, cell-wall formation Pkinase PF00069.25 EFE42462.1 - 2.5e-66 223.7 0.0 5.6e-66 222.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42462.1 - 1.5e-41 142.4 0.0 2.2e-41 141.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE42462.1 - 2.9e-08 33.4 0.0 4.3e-07 29.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFE42462.1 - 9.9e-06 24.7 0.0 9.9e-06 24.7 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain PRKG1_interact PF15898.5 EFE42462.1 - 0.018 15.9 2.9 0.059 14.3 2.9 1.8 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Kdo PF06293.14 EFE42462.1 - 0.04 13.3 0.0 0.04 13.3 0.0 2.1 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE42462.1 - 0.83 9.5 7.4 1.2 9.0 0.1 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.22 EFE42462.1 - 2.8 7.5 4.3 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 RIO1 family MFS_1 PF07690.16 EFE42463.1 - 4.8e-14 52.1 33.1 1.8e-12 46.8 33.4 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily HlyIII PF03006.20 EFE42463.1 - 0.00017 21.4 9.0 0.0018 18.0 0.1 3.1 1 1 0 3 3 3 2 Haemolysin-III related TRIQK PF15168.6 EFE42463.1 - 0.22 11.5 1.9 0.54 10.2 0.2 2.4 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family Sugar_tr PF00083.24 EFE42463.1 - 0.76 8.6 26.3 14 4.4 23.6 2.9 1 1 0 1 1 1 0 Sugar (and other) transporter DUF4293 PF14126.6 EFE42463.1 - 0.85 9.9 7.7 2.3 8.5 6.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) Eisosome1 PF12757.7 EFE42464.1 - 1.7e-28 99.4 2.2 1.7e-28 99.4 2.2 2.2 2 0 0 2 2 2 1 Eisosome protein 1 Trypsin_2 PF13365.6 EFE42465.1 - 8e-27 95.0 0.0 1.2e-26 94.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFE42465.1 - 0.001 18.9 0.0 0.0027 17.6 0.0 1.7 1 1 0 1 1 1 1 Trypsin Peptidase_S32 PF05579.13 EFE42465.1 - 0.13 11.4 0.1 0.66 9.1 0.0 1.9 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 DUF1640 PF07798.11 EFE42466.1 - 7.6e-49 166.1 10.5 1.1e-48 165.6 10.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) BST2 PF16716.5 EFE42466.1 - 2.6 8.7 5.6 1.2 9.7 0.6 2.5 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 PMM PF03332.13 EFE42467.1 - 8.5e-104 346.1 0.1 9.9e-104 345.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EFE42467.1 - 2.5e-05 24.1 0.0 0.00014 21.7 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TMPIT PF07851.13 EFE42467.1 - 0.015 14.6 0.1 0.02 14.2 0.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein MFS_1 PF07690.16 EFE42468.1 - 5.9e-38 130.7 50.2 2.2e-37 128.8 50.2 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily DnaJ PF00226.31 EFE42469.1 - 2.2e-10 40.5 0.3 3.9e-10 39.7 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain DUF456 PF04306.13 EFE42469.1 - 0.00051 20.3 1.5 0.0008 19.7 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF456) DUF2076 PF09849.9 EFE42469.1 - 0.0015 18.7 0.9 0.0026 17.9 0.9 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Bacteriocin_IIc PF10439.9 EFE42469.1 - 1 9.5 8.5 1.8 8.8 8.5 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide FAM76 PF16046.5 EFE42470.1 - 1.4 8.2 3.2 1.8 7.9 3.2 1.1 1 0 0 1 1 1 0 FAM76 protein Macoilin PF09726.9 EFE42470.1 - 10 4.6 6.7 12 4.3 6.7 1.0 1 0 0 1 1 1 0 Macoilin family MBOAT_2 PF13813.6 EFE42471.1 - 2.8e-18 65.9 4.3 2.8e-18 65.9 4.3 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Peptidase_S8 PF00082.22 EFE42473.1 - 1.9e-30 106.2 17.1 1.9e-30 106.2 17.1 1.6 2 1 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.16 EFE42473.1 - 1.6e-15 57.5 0.4 2.8e-15 56.8 0.4 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 E1-E2_ATPase PF00122.20 EFE42474.1 - 7.6e-51 172.2 5.1 2.9e-49 167.0 2.1 2.9 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFE42474.1 - 2.2e-46 157.8 7.6 2.2e-46 157.8 7.6 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFE42474.1 - 1.7e-22 80.7 0.2 7.7e-22 78.6 0.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFE42474.1 - 8.6e-20 70.2 0.1 2.9e-19 68.5 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFE42474.1 - 4.4e-16 58.8 0.0 8.5e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFE42474.1 - 3.7e-08 33.4 1.5 6.7e-06 26.0 1.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFE42474.1 - 1.1e-06 29.2 0.0 4.3e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase adh_short PF00106.25 EFE42475.1 - 8.2e-21 74.3 0.0 1.8e-18 66.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFE42475.1 - 1.3e-09 37.9 0.0 2.4e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE42475.1 - 7.9e-05 22.6 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 KR domain 14-3-3 PF00244.20 EFE42476.1 - 1.6e-90 302.5 6.4 6e-87 290.8 6.4 2.1 1 1 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.6 EFE42476.1 - 0.027 13.9 0.1 0.039 13.4 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase eIF3_subunit PF08597.10 EFE42477.1 - 2.8e-67 227.2 29.7 2.8e-67 227.2 29.7 2.3 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit Enolase_C PF00113.22 EFE42478.1 - 1.8e-153 510.0 0.0 2.3e-153 509.6 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EFE42478.1 - 1.4e-35 122.4 0.1 2.5e-35 121.5 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EFE42478.1 - 0.0002 21.0 0.0 0.00036 20.2 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like VSP PF03302.13 EFE42478.1 - 0.097 11.5 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein Cation_ATPase_C PF00689.21 EFE42480.1 - 1.6e-43 148.5 3.7 1.6e-43 148.5 3.7 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFE42480.1 - 1.2e-38 132.5 3.4 9.9e-38 129.5 1.3 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFE42480.1 - 5e-21 76.0 0.0 1.1e-08 35.6 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE42480.1 - 4.4e-19 68.4 0.0 8.3e-19 67.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFE42480.1 - 1.4e-11 43.9 0.0 2.9e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFE42480.1 - 0.00013 21.8 0.3 0.00042 20.1 0.2 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFE42480.1 - 0.0014 19.1 0.0 0.24 11.8 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2157 PF09925.9 EFE42480.1 - 2.7 7.8 5.9 8.6 6.1 0.8 3.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) AAA PF00004.29 EFE42481.1 - 2.2e-39 134.9 0.0 4e-39 134.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFE42481.1 - 3.8e-11 42.8 0.0 1e-10 41.4 0.0 1.8 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EFE42481.1 - 1.7e-10 40.5 0.1 3.2e-10 39.6 0.1 1.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EFE42481.1 - 8e-08 32.8 0.0 7.2e-05 23.2 0.0 2.7 2 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EFE42481.1 - 2.2e-06 27.7 0.0 1.7e-05 24.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFE42481.1 - 1.5e-05 25.2 0.0 5.2e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFE42481.1 - 6.7e-05 23.2 0.0 0.0004 20.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFE42481.1 - 0.00083 19.1 0.0 0.0024 17.6 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EFE42481.1 - 0.0022 18.0 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 EFE42481.1 - 0.0024 18.4 0.0 0.019 15.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFE42481.1 - 0.0035 16.9 0.0 0.012 15.1 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region Prot_ATP_OB_N PF17758.1 EFE42481.1 - 0.0046 16.6 0.0 0.013 15.2 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain RNA_helicase PF00910.22 EFE42481.1 - 0.0046 17.3 0.0 0.0086 16.5 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 EFE42481.1 - 0.0059 16.0 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EFE42481.1 - 0.014 15.1 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EFE42481.1 - 0.016 15.4 0.0 0.037 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EFE42481.1 - 0.026 13.8 0.1 0.14 11.5 0.0 2.1 2 0 0 2 2 2 0 KaiC TIP49 PF06068.13 EFE42481.1 - 0.029 13.6 0.0 0.058 12.6 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_3 PF07726.11 EFE42481.1 - 0.031 14.2 0.0 0.072 13.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFE42481.1 - 0.045 13.5 0.1 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFE42481.1 - 0.061 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EFE42481.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein TsaE PF02367.17 EFE42481.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_13 PF13166.6 EFE42481.1 - 0.12 11.1 0.1 1.1 7.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EFE42481.1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 EFE42481.1 - 0.12 12.1 0.1 0.42 10.3 0.0 1.9 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 EFE42481.1 - 0.15 11.8 0.3 0.34 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain Glyco_hydro_47 PF01532.20 EFE42482.1 - 2.6e-158 527.7 0.0 5e-158 526.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 M20_dimer PF07687.14 EFE42483.1 - 1.6e-20 73.0 0.0 3.6e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EFE42483.1 - 2.6e-15 56.7 0.2 8.9e-14 51.7 0.2 2.3 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EFE42483.1 - 0.00039 19.6 0.0 0.0032 16.6 0.0 2.2 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase DUF373 PF04123.13 EFE42483.1 - 0.019 14.4 0.3 0.031 13.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Peptidase_M28 PF04389.17 EFE42483.1 - 0.041 13.6 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 HATPase_c PF02518.26 EFE42484.1 - 6.1e-18 65.4 0.0 2e-17 63.7 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFE42484.1 - 9.9e-15 54.7 0.4 4.6e-09 36.4 0.0 3.4 2 1 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 EFE42484.1 - 6.6e-05 22.9 0.1 0.00027 20.9 0.1 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EFE42484.1 - 0.037 13.8 0.0 0.11 12.3 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GREB1 PF15782.5 EFE42484.1 - 2.8 4.9 7.3 5.4 4.0 7.3 1.4 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ctr PF04145.15 EFE42484.1 - 7.4 7.2 6.8 32 5.1 1.0 3.2 3 0 0 3 3 3 0 Ctr copper transporter family Ribosomal_L36e PF01158.18 EFE42485.1 - 5.1e-38 129.2 7.1 5.7e-38 129.1 7.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e HTH_38 PF13936.6 EFE42485.1 - 0.0095 15.7 1.6 0.22 11.3 0.1 2.6 2 1 0 2 2 2 1 Helix-turn-helix domain PBS_linker_poly PF00427.21 EFE42485.1 - 0.04 14.0 0.4 0.044 13.8 0.4 1.1 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide LemA PF04011.12 EFE42485.1 - 0.13 12.1 0.3 0.16 11.8 0.3 1.2 1 0 0 1 1 1 0 LemA family MRP-L28 PF09812.9 EFE42485.1 - 0.13 12.4 2.6 0.15 12.2 2.6 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 DUF2207 PF09972.9 EFE42485.1 - 0.13 11.0 0.1 0.14 10.9 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4239 PF14023.6 EFE42485.1 - 0.14 11.9 0.1 0.18 11.5 0.1 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) TUG-UBL1 PF11470.8 EFE42486.1 - 1.3e-24 86.2 0.4 2.9e-24 85.1 0.1 1.8 2 0 0 2 2 2 1 TUG ubiquitin-like domain UBX PF00789.20 EFE42486.1 - 0.00015 21.9 0.1 0.00083 19.5 0.0 2.3 3 0 0 3 3 3 1 UBX domain RBD PF02196.15 EFE42486.1 - 0.01 15.9 0.0 0.064 13.3 0.0 2.1 2 0 0 2 2 2 0 Raf-like Ras-binding domain Proteasome PF00227.26 EFE42487.1 - 1.2e-41 142.3 0.0 1.5e-41 142.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit NatB_MDM20 PF09797.9 EFE42488.1 - 1.8e-101 339.9 0.4 2.8e-101 339.2 0.4 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 EFE42488.1 - 0.00011 22.6 7.9 0.0059 17.1 0.2 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFE42488.1 - 0.69 10.9 9.8 73 4.6 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Methyltransf_23 PF13489.6 EFE42490.1 - 1.8e-09 37.7 0.0 2.5e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE42490.1 - 0.014 16.0 0.0 0.052 14.3 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain WD40 PF00400.32 EFE42491.1 - 0.0075 17.1 3.9 3.7 8.6 0.1 4.1 5 0 0 5 5 5 2 WD domain, G-beta repeat eIF2A PF08662.11 EFE42491.1 - 0.15 11.9 0.1 0.91 9.4 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A RNA_pol_Rpb1_1 PF04997.12 EFE42492.1 - 3.4e-112 374.8 0.0 6.1e-112 374.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EFE42492.1 - 4.9e-105 350.8 0.0 8e-105 350.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFE42492.1 - 8.3e-75 250.6 0.0 2e-74 249.4 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EFE42492.1 - 2.4e-65 220.0 1.4 4.5e-65 219.1 1.4 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EFE42492.1 - 7.1e-47 159.2 0.0 1.7e-46 158.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EFE42492.1 - 2.5e-44 150.6 7.7 3.7e-44 150.0 5.9 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EFE42492.1 - 7.5e-38 128.8 0.2 1.6e-37 127.7 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EFE42492.1 - 5.8e-17 61.1 200.0 0.011 16.1 1.4 14.0 12 1 1 13 13 13 10 RNA polymerase Rpb1 C-terminal repeat AF-4 PF05110.13 EFE42493.1 - 0.0064 14.7 21.0 0.0072 14.5 21.0 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein LAP1C PF05609.12 EFE42493.1 - 0.018 14.2 12.9 0.026 13.6 12.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 EFE42493.1 - 0.37 9.3 13.0 0.46 9.0 13.0 1.1 1 0 0 1 1 1 0 Macoilin family CDC27 PF09507.10 EFE42493.1 - 1.2 8.4 38.5 1.7 8.0 38.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SRP-alpha_N PF04086.13 EFE42493.1 - 3.8 7.4 31.6 6.2 6.7 31.6 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Leu_zip PF15294.6 EFE42494.1 - 0.0094 15.5 23.0 0.016 14.8 23.0 1.3 1 0 0 1 1 1 1 Leucine zipper DUF4407 PF14362.6 EFE42494.1 - 0.15 11.4 23.4 0.25 10.7 23.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Snapin_Pallidin PF14712.6 EFE42494.1 - 1 9.9 23.3 3.7 8.0 1.1 3.4 2 1 0 2 2 2 0 Snapin/Pallidin T3SSipB PF16535.5 EFE42494.1 - 2.4 8.6 12.5 2.5 8.6 10.8 1.8 1 1 1 2 2 2 0 Type III cell invasion protein SipB LNS2 PF08235.13 EFE42495.1 - 2.7e-95 318.1 0.0 3.6e-95 317.7 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EFE42495.1 - 1.1e-22 79.9 0.1 1.1e-10 41.3 0.0 2.5 2 0 0 2 2 2 2 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 EFE42495.1 - 0.022 14.3 0.0 0.16 11.6 0.0 2.2 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) TFIID-31kDa PF02291.15 EFE42496.1 - 5.6e-45 152.4 0.0 7.5e-45 151.9 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Utp11 PF03998.13 EFE42498.1 - 4.9e-57 193.7 29.6 5.6e-57 193.5 29.6 1.0 1 0 0 1 1 1 1 Utp11 protein GCIP PF13324.6 EFE42498.1 - 0.34 10.5 7.2 0.47 10.0 7.2 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Myc_N PF01056.18 EFE42498.1 - 2.8 7.8 9.6 3.8 7.3 9.6 1.2 1 0 0 1 1 1 0 Myc amino-terminal region TRAM_LAG1_CLN8 PF03798.16 EFE42499.1 - 1e-38 133.1 19.5 1.7e-38 132.4 19.5 1.3 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EFE42499.1 - 1.1e-21 76.2 0.0 3.3e-21 74.7 0.0 1.8 1 0 0 1 1 1 1 TRAM1-like protein SAPS PF04499.15 EFE42500.1 - 2.2 7.0 7.8 2.2 7.0 7.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein REC114-like PF15165.6 EFE42500.1 - 5.2 6.8 5.6 11 5.7 5.6 1.5 1 1 0 1 1 1 0 Meiotic recombination protein REC114-like HEAT PF02985.22 EFE42501.1 - 3.2e-10 39.4 6.6 0.61 10.5 0.0 7.4 9 0 0 9 9 9 4 HEAT repeat HEAT_EZ PF13513.6 EFE42501.1 - 3.3e-05 24.3 5.8 18 6.0 0.0 8.1 8 0 0 8 8 8 1 HEAT-like repeat RTP1_C1 PF10363.9 EFE42501.1 - 0.00062 19.9 0.1 0.038 14.2 0.0 3.6 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 EFE42501.1 - 0.00096 19.2 0.0 0.0054 16.8 0.0 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFE42501.1 - 0.0035 17.9 0.0 2.6 8.7 0.0 4.6 4 1 0 4 4 4 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EFE42501.1 - 0.0066 15.1 0.1 13 4.2 0.0 4.7 4 1 1 5 5 5 1 Adaptin N terminal region DUF3295 PF11702.8 EFE42501.1 - 0.014 14.7 0.3 0.021 14.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DRIM PF07539.12 EFE42501.1 - 0.016 13.5 1.2 9.8 4.3 0.0 4.2 4 1 1 5 5 5 0 Down-regulated in metastasis V-ATPase_H_C PF11698.8 EFE42501.1 - 0.2 11.8 0.1 42 4.3 0.0 3.7 5 0 0 5 5 5 0 V-ATPase subunit H TIP120 PF08623.10 EFE42502.1 - 1.8e-60 203.6 0.0 2e-60 203.4 0.0 1.0 1 0 0 1 1 1 1 TATA-binding protein interacting (TIP20) PalH PF08733.10 EFE42504.1 - 4e-112 374.5 0.0 5e-112 374.2 0.0 1.1 1 0 0 1 1 1 1 PalH/RIM21 Atg14 PF10186.9 EFE42507.1 - 3.9e-17 62.3 0.0 7.1e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 FUSC PF04632.12 EFE42507.1 - 1.4 7.4 6.5 2.1 6.8 6.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Mhr1 PF12829.7 EFE42508.1 - 1.1e-27 95.9 0.2 2.5e-27 94.8 0.2 1.6 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination RR_TM4-6 PF06459.12 EFE42508.1 - 6.2 6.6 11.9 10 5.8 11.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PP2C PF00481.21 EFE42509.1 - 2.3e-62 211.0 1.9 1.7e-49 168.8 0.0 3.8 3 1 0 3 3 3 2 Protein phosphatase 2C AAA_33 PF13671.6 EFE42509.1 - 0.043 14.0 1.0 0.12 12.6 0.0 2.2 3 0 0 3 3 3 0 AAA domain Snf7 PF03357.21 EFE42511.1 - 1.4e-28 99.7 10.7 4.8e-28 97.9 9.7 1.8 2 0 0 2 2 2 1 Snf7 Sugar_tr PF00083.24 EFE42512.1 - 4.1e-110 368.7 16.9 4.9e-110 368.5 16.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE42512.1 - 1.2e-25 90.2 32.9 6e-25 87.9 17.3 2.4 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 EFE42512.1 - 1.5e-05 24.1 0.3 2.8e-05 23.2 0.3 1.4 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM DUF2530 PF10745.9 EFE42512.1 - 0.041 14.1 1.6 0.3 11.3 1.6 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2530) Transglut_core PF01841.19 EFE42513.1 - 3.3e-13 50.1 0.0 6.4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Ras PF00071.22 EFE42514.1 - 5.6e-21 74.8 0.0 8.8e-21 74.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE42514.1 - 3.3e-19 69.3 0.0 3.3e-19 69.3 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE42514.1 - 1.2e-06 28.1 0.0 2.2e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFE42514.1 - 0.0025 17.2 0.0 0.0025 17.2 0.0 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region CrgA PF06781.12 EFE42514.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Cell division protein CrgA TFIIA PF03153.13 EFE42514.1 - 0.15 12.0 30.7 0.19 11.7 30.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MMR_HSR1 PF01926.23 EFE42514.1 - 0.22 11.6 1.9 0.25 11.4 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase LAP1C PF05609.12 EFE42514.1 - 7.4 5.5 14.5 9.9 5.1 14.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CAF1C_H4-bd PF12265.8 EFE42515.1 - 7.3e-16 58.2 0.1 3.7e-15 55.9 0.0 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EFE42515.1 - 7.6e-14 51.9 7.9 2.7e-06 28.0 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE42515.1 - 1.4e-07 31.7 2.0 0.00098 19.4 0.3 3.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE42515.1 - 0.032 12.9 2.6 0.14 10.8 0.2 2.2 1 1 0 2 2 2 0 Nucleoporin Nup120/160 UL41A PF17591.2 EFE42515.1 - 0.19 11.8 0.0 0.64 10.1 0.0 1.9 1 0 0 1 1 1 0 Herpesvirus UL41A Vpu PF00558.19 EFE42515.1 - 0.25 11.1 1.7 0.5 10.2 1.7 1.4 1 0 0 1 1 1 0 Vpu protein Fungal_trans PF04082.18 EFE42517.1 - 1.9e-21 76.3 1.1 1.9e-21 76.3 1.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EFE42517.1 - 2.7e-09 37.0 14.0 7.4e-05 23.0 2.1 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE42517.1 - 2.1e-06 27.9 12.7 3.2e-06 27.3 6.6 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE42517.1 - 0.00033 21.3 13.1 0.042 14.7 2.0 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger Tape_meas_lam_C PF09718.10 EFE42517.1 - 0.081 13.1 0.8 0.91 9.7 0.0 3.1 3 0 0 3 3 3 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Utp8 PF10395.9 EFE42519.1 - 4.4e-07 28.8 0.2 2.6e-06 26.3 0.3 2.3 2 1 0 2 2 2 1 Utp8 family PX PF00787.24 EFE42520.1 - 1.8e-16 60.1 0.2 4.8e-16 58.8 0.2 1.8 1 0 0 1 1 1 1 PX domain AAA PF00004.29 EFE42520.1 - 5.9e-08 33.2 0.8 3.7e-07 30.6 0.8 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFE42520.1 - 0.00015 21.8 0.2 0.057 13.3 0.1 3.2 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 EFE42520.1 - 0.0023 18.3 0.0 0.01 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFE42520.1 - 0.015 15.0 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EFE42520.1 - 0.061 12.5 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_22 PF13401.6 EFE42520.1 - 0.1 12.9 0.0 0.43 10.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFE42520.1 - 0.13 12.3 0.0 0.43 10.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 EFE42520.1 - 0.14 11.2 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.6 EFE42520.1 - 0.51 10.5 2.7 0.83 9.8 0.0 2.8 4 0 0 4 4 4 0 AAA domain Nha1_C PF08619.10 EFE42521.1 - 3e-81 274.0 15.8 4e-81 273.6 15.8 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 EFE42521.1 - 1.1e-72 244.9 19.7 1.4e-72 244.6 19.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 EFE42521.1 - 0.047 13.8 0.3 0.047 13.8 0.3 2.5 3 0 0 3 3 3 0 YrhC-like protein DUF21 PF01595.20 EFE42521.1 - 9.6 5.9 7.3 0.96 9.1 2.4 1.9 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain SAM_2 PF07647.17 EFE42522.1 - 3.1e-15 56.0 0.0 5.1e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EFE42522.1 - 5.2e-12 46.2 0.1 1.3e-11 45.0 0.0 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.30 EFE42522.1 - 7.8e-12 45.5 0.0 1.2e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 EFE42522.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) EnY2 PF10163.9 EFE42523.1 - 1.5e-07 31.7 0.0 2.9e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Transcription factor e(y)2 AAA PF00004.29 EFE42524.1 - 1.3e-96 320.1 0.0 2.4e-47 160.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE42524.1 - 3.7e-24 84.3 5.5 7.6e-13 48.0 0.3 3.2 2 1 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EFE42524.1 - 1.2e-18 67.0 1.4 2.6e-18 66.0 0.6 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 EFE42524.1 - 4.7e-14 52.9 0.0 1.2e-07 32.0 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFE42524.1 - 1.3e-13 51.0 0.0 1.6e-05 24.7 0.0 3.3 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EFE42524.1 - 3.8e-12 46.6 0.0 2.7e-05 24.3 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EFE42524.1 - 5.9e-11 43.1 0.0 0.00017 22.0 0.0 4.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 EFE42524.1 - 4.9e-10 39.5 0.6 5.3e-05 23.3 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFE42524.1 - 9.1e-09 35.7 0.4 0.06 13.6 0.0 4.2 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.13 EFE42524.1 - 9.8e-09 34.9 0.1 0.0017 17.7 0.0 2.5 2 1 0 2 2 2 2 TIP49 P-loop domain CDC48_2 PF02933.17 EFE42524.1 - 5.4e-08 32.5 0.0 1.3e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 IstB_IS21 PF01695.17 EFE42524.1 - 4.1e-07 29.9 0.0 0.022 14.5 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 EFE42524.1 - 5.7e-07 29.1 0.4 0.037 13.4 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFE42524.1 - 1.4e-06 28.9 0.0 0.063 13.8 0.0 3.0 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 EFE42524.1 - 1.7e-06 27.6 0.5 0.74 9.1 0.0 3.5 3 0 0 3 3 3 2 KaiC Vps4_C PF09336.10 EFE42524.1 - 2.2e-06 27.6 0.4 1.9e-05 24.5 0.1 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 EFE42524.1 - 2.3e-06 27.9 0.0 0.032 14.6 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EFE42524.1 - 3.8e-06 27.0 0.0 0.027 14.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EFE42524.1 - 5.7e-06 26.0 6.0 0.4 10.2 0.2 4.9 3 2 0 4 4 4 2 AAA domain AAA_7 PF12775.7 EFE42524.1 - 9.5e-06 25.2 0.1 0.04 13.4 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 EFE42524.1 - 4e-05 23.9 0.0 0.34 11.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 EFE42524.1 - 5e-05 22.6 0.0 0.01 15.1 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 EFE42524.1 - 6.6e-05 23.4 0.0 0.3 11.6 0.0 3.4 2 1 0 2 2 2 1 ABC transporter Sigma54_activat PF00158.26 EFE42524.1 - 0.0001 22.1 0.1 0.87 9.3 0.0 3.2 2 2 0 2 2 2 2 Sigma-54 interaction domain PhoH PF02562.16 EFE42524.1 - 0.00011 21.8 0.4 0.39 10.1 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_24 PF13479.6 EFE42524.1 - 0.00011 22.0 0.0 0.75 9.5 0.0 2.8 3 0 0 3 3 2 2 AAA domain Parvo_NS1 PF01057.17 EFE42524.1 - 0.00013 21.1 0.1 0.11 11.5 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.18 EFE42524.1 - 0.00037 20.4 0.0 0.82 9.5 0.0 2.8 3 0 0 3 3 2 2 Bacterial dnaA protein AAA_11 PF13086.6 EFE42524.1 - 0.00037 20.4 0.0 0.48 10.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EFE42524.1 - 0.00047 20.2 0.0 0.13 12.3 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_17 PF13207.6 EFE42524.1 - 0.00054 20.4 0.0 1 9.8 0.0 3.1 3 0 0 3 3 2 1 AAA domain TsaE PF02367.17 EFE42524.1 - 0.00077 19.5 0.0 0.71 9.9 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 EFE42524.1 - 0.00091 19.1 0.0 1.8 8.4 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 EFE42524.1 - 0.0023 17.3 0.0 0.96 8.6 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EFE42524.1 - 0.0051 16.6 0.6 2.9 7.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EFE42524.1 - 0.0065 16.4 0.0 13 5.6 0.0 3.5 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EFE42524.1 - 0.007 16.7 0.7 7.8 6.8 0.0 3.5 3 1 0 4 4 2 0 AAA domain NACHT PF05729.12 EFE42524.1 - 0.0093 15.9 0.1 1.9 8.4 0.0 3.0 3 0 0 3 3 3 1 NACHT domain Viral_helicase1 PF01443.18 EFE42524.1 - 0.01 15.6 0.0 0.75 9.5 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase UFD1 PF03152.14 EFE42524.1 - 0.02 14.3 0.0 0.18 11.2 0.0 2.3 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 NB-ARC PF00931.22 EFE42524.1 - 0.021 14.0 0.2 2.2 7.4 0.0 2.9 3 0 0 3 3 3 0 NB-ARC domain Zeta_toxin PF06414.12 EFE42524.1 - 0.023 14.0 1.0 7 5.9 0.0 3.1 4 0 0 4 4 3 0 Zeta toxin KAP_NTPase PF07693.14 EFE42524.1 - 0.024 13.9 0.0 0.83 8.8 0.0 2.5 2 1 0 2 2 2 0 KAP family P-loop domain Sigma54_activ_2 PF14532.6 EFE42524.1 - 0.025 14.7 0.0 4.2 7.5 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain eIF-1a PF01176.19 EFE42524.1 - 0.033 14.0 0.6 1 9.2 0.5 2.7 2 1 0 2 2 1 0 Translation initiation factor 1A / IF-1 IPT PF01745.16 EFE42524.1 - 0.035 13.5 0.1 2.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase NTPase_1 PF03266.15 EFE42524.1 - 0.072 13.0 2.9 4.2 7.3 0.0 4.1 5 0 0 5 5 3 0 NTPase AAA_6 PF12774.7 EFE42524.1 - 0.14 11.0 0.1 12 4.8 0.0 2.4 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Zot PF05707.12 EFE42524.1 - 0.19 11.4 0.0 7.9 6.1 0.0 2.9 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) SLATT_5 PF18160.1 EFE42526.1 - 0.16 11.3 0.0 0.47 9.8 0.1 1.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 PsiF_repeat PF07769.14 EFE42528.1 - 0.065 13.1 0.1 0.2 11.6 0.1 1.8 2 0 0 2 2 2 0 psiF repeat PEX11 PF05648.14 EFE42529.1 - 2.2e-16 60.0 1.1 1.9e-14 53.6 0.2 2.1 2 0 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) IBR PF01485.21 EFE42530.1 - 0.51 10.6 3.9 0.5 10.6 0.2 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Mpv17_PMP22 PF04117.12 EFE42531.1 - 1.6e-10 41.0 5.4 6.4e-10 39.1 0.7 2.8 3 0 0 3 3 3 1 Mpv17 / PMP22 family CKAP2_C PF15297.6 EFE42531.1 - 0.21 10.6 0.0 0.4 9.7 0.0 1.4 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus SprT-like PF10263.9 EFE42532.1 - 3.1e-10 39.9 0.0 3.1e-10 39.9 0.0 1.7 2 0 0 2 2 2 1 SprT-like family Cullin_binding PF03556.15 EFE42533.1 - 3.2e-31 108.3 2.4 4.8e-31 107.7 2.4 1.3 1 0 0 1 1 1 1 Cullin binding NOC3p PF07540.11 EFE42534.1 - 2.7e-29 101.5 0.3 1.9e-28 98.7 0.2 2.5 2 0 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.17 EFE42534.1 - 1.4e-24 87.0 1.4 9.5e-23 81.1 0.0 3.0 2 1 0 2 2 2 1 CBF/Mak21 family Adaptin_N PF01602.20 EFE42534.1 - 0.01 14.4 1.5 4.2 5.8 0.0 3.0 3 0 0 3 3 3 0 Adaptin N terminal region Orbi_VP1 PF05788.12 EFE42534.1 - 0.039 11.5 0.2 0.06 10.9 0.2 1.1 1 0 0 1 1 1 0 Orbivirus RNA-dependent RNA polymerase (VP1) NUDE_C PF04880.13 EFE42535.1 - 1.6 9.2 4.4 3.4 8.1 0.3 2.5 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region AMPK1_CBM PF16561.5 EFE42536.1 - 2.6e-07 30.8 0.2 6.4e-07 29.5 0.2 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase DUF1349 PF07081.11 EFE42538.1 - 1.6e-22 80.1 0.0 3e-22 79.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) MRP-L46 PF11788.8 EFE42539.1 - 7.1e-39 133.2 0.2 1.1e-38 132.7 0.2 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 HLH PF00010.26 EFE42540.1 - 1.5e-11 44.1 0.0 6.8e-11 42.0 0.0 2.1 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mito_carr PF00153.27 EFE42541.1 - 9.8e-40 134.4 0.1 1.9e-18 66.2 0.0 2.3 3 0 0 3 3 3 2 Mitochondrial carrier protein Dna2 PF08696.11 EFE42542.1 - 1.6e-67 227.3 0.0 3.6e-67 226.1 0.0 1.7 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 EFE42542.1 - 1.1e-53 181.9 0.0 1.8e-53 181.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFE42542.1 - 1.7e-33 116.5 0.1 2.3e-17 63.6 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 EFE42542.1 - 2.7e-14 53.3 0.0 4.9e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFE42542.1 - 4.1e-11 43.4 0.1 9.5e-11 42.2 0.1 1.7 1 0 0 1 1 1 1 AAA domain PDDEXK_1 PF12705.7 EFE42542.1 - 8.8e-09 35.6 0.0 4.8e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 PD-(D/E)XK nuclease superfamily Cas_Cas4 PF01930.17 EFE42542.1 - 5.4e-08 33.1 0.0 7.3e-06 26.2 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.18 EFE42542.1 - 7.1e-07 29.2 0.3 0.21 11.3 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 EFE42542.1 - 8.4e-05 22.5 0.0 0.0002 21.3 0.0 1.6 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 EFE42542.1 - 0.00057 19.5 0.7 0.0014 18.2 0.1 1.9 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.22 EFE42542.1 - 0.0012 18.5 0.1 0.0022 17.6 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EFE42542.1 - 0.0042 17.5 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain PIF1 PF05970.14 EFE42542.1 - 0.017 14.3 0.2 0.052 12.7 0.2 1.8 1 1 0 1 1 1 0 PIF1-like helicase DUF2075 PF09848.9 EFE42542.1 - 0.021 14.1 0.0 0.039 13.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EFE42542.1 - 0.037 14.0 0.1 0.11 12.5 0.1 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA PF00004.29 EFE42542.1 - 0.046 14.2 0.1 0.22 11.9 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 EFE42542.1 - 0.053 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.23 EFE42542.1 - 0.056 13.5 0.5 0.14 12.2 0.5 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF87 PF01935.17 EFE42542.1 - 0.056 13.5 0.1 0.14 12.2 0.1 1.7 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_7 PF12775.7 EFE42542.1 - 0.063 12.8 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EFE42542.1 - 0.085 12.8 0.3 0.18 11.7 0.3 1.4 1 0 0 1 1 1 0 NTPase FtsK_SpoIIIE PF01580.18 EFE42542.1 - 0.12 11.7 0.1 0.24 10.7 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family MeaB PF03308.16 EFE42542.1 - 0.19 10.7 0.1 0.38 9.7 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ribonuc_P_40 PF08584.11 EFE42543.1 - 1e-52 179.2 0.0 6.3e-52 176.6 0.0 1.8 1 1 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit WD40 PF00400.32 EFE42544.1 - 7.8e-27 93.0 15.2 8.7e-06 26.4 0.0 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE42544.1 - 8.3e-15 54.9 0.0 0.0052 17.1 0.0 5.6 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFE42544.1 - 1.5e-07 30.3 0.0 0.0027 16.3 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 EFE42544.1 - 0.0018 18.2 0.0 2 8.2 0.0 2.9 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EFE42544.1 - 0.011 15.7 4.2 4.5 7.3 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 EFE42544.1 - 0.062 12.2 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain DPPIV_N PF00930.21 EFE42544.1 - 0.071 11.9 0.0 0.27 10.0 0.0 1.9 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Ge1_WD40 PF16529.5 EFE42544.1 - 0.072 12.0 0.0 4.9 6.0 0.0 3.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFE42544.1 - 0.22 10.1 0.1 9 4.8 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Fungal_trans PF04082.18 EFE42545.1 - 2.9e-18 65.9 0.1 6.3e-18 64.8 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE42545.1 - 8.6e-10 38.6 9.6 1.9e-09 37.5 9.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MCCD1 PF15707.5 EFE42545.1 - 0.13 12.7 0.2 4.6 7.8 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial coiled-coil domain protein 1 Ribosomal_L2_C PF03947.18 EFE42546.1 - 3.8e-48 162.8 3.4 1.8e-34 118.6 1.9 2.8 3 0 0 3 3 3 2 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EFE42546.1 - 8.3e-24 83.3 0.5 2.1e-23 82.0 0.5 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Cyclin_N PF00134.23 EFE42547.1 - 6.7e-47 158.4 0.1 5.5e-45 152.2 0.1 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFE42547.1 - 4.5e-31 107.4 0.0 8.5e-31 106.5 0.0 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF2868 PF11067.8 EFE42547.1 - 3.1 7.2 8.5 8.5 5.8 8.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2868) UPF0020 PF01170.18 EFE42548.1 - 1.2e-09 38.1 0.0 1.9e-08 34.2 0.0 2.3 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 EFE42548.1 - 5.5e-05 22.6 0.0 8.6e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 N-6 DNA Methylase MethyltransfD12 PF02086.15 EFE42548.1 - 0.049 13.3 0.0 0.17 11.5 0.0 1.9 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase DUF2985 PF11204.8 EFE42550.1 - 7.7e-10 38.8 8.4 1.1e-06 28.6 0.1 2.7 1 1 1 2 2 2 2 Protein of unknown function (DUF2985) LTXXQ PF07813.12 EFE42550.1 - 0.0013 19.4 0.3 0.0013 19.4 0.3 2.4 2 0 0 2 2 2 1 LTXXQ motif family protein SID-1_RNA_chan PF13965.6 EFE42550.1 - 0.36 9.2 2.3 0.65 8.3 2.3 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Peptidase_S49_N PF08496.10 EFE42550.1 - 1.7 8.7 9.5 1.9 8.6 5.7 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Pkinase PF00069.25 EFE42551.1 - 4.5e-05 23.0 0.0 9.3e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EFE42551.1 - 5.5e-05 22.6 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE42551.1 - 0.006 16.5 0.1 0.006 16.5 0.1 3.1 2 1 0 3 3 3 1 Phosphotransferase enzyme family FemAB PF02388.16 EFE42551.1 - 0.18 10.6 2.2 0.31 9.9 2.2 1.3 1 0 0 1 1 1 0 FemAB family DUF2514 PF10721.9 EFE42551.1 - 0.44 10.6 14.6 0.97 9.5 14.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) GvpL_GvpF PF06386.11 EFE42551.1 - 1.2 9.0 7.6 3.2 7.6 7.6 1.8 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF4407 PF14362.6 EFE42551.1 - 2.1 7.6 5.1 3.6 6.9 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PIEZO PF15917.5 EFE42551.1 - 2.1 7.8 8.2 4.7 6.6 2.5 2.6 2 0 0 2 2 2 0 Piezo GAS PF13851.6 EFE42551.1 - 2.2 7.6 13.9 4.5 6.6 13.9 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Ctr PF04145.15 EFE42551.1 - 7.6 7.1 5.1 97 3.6 1.6 3.3 3 0 0 3 3 3 0 Ctr copper transporter family Borrelia_P83 PF05262.11 EFE42551.1 - 8.6 4.7 13.5 17 3.8 13.5 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein SIR2 PF02146.17 EFE42552.1 - 1.3e-59 201.1 0.0 1.8e-59 200.6 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 EFE42552.1 - 1.4e-05 24.9 0.0 2.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EFE42552.1 - 0.0011 18.7 0.2 1.9 8.2 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain TPR_2 PF07719.17 EFE42553.1 - 8.5e-13 47.4 0.0 0.0001 22.1 0.0 4.9 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFE42553.1 - 2.6e-11 43.9 0.0 1.3e-05 25.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFE42553.1 - 7.3e-10 38.8 1.6 0.18 12.7 0.0 5.4 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE42553.1 - 7.5e-10 39.0 0.0 1.3e-05 25.4 0.0 3.8 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFE42553.1 - 3.3e-09 36.2 0.0 1.4e-05 24.9 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFE42553.1 - 1.2e-08 34.4 0.0 0.00031 20.4 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFE42553.1 - 1.9e-06 28.4 0.0 2 9.1 0.0 3.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFE42553.1 - 9.3e-06 25.7 0.3 1.3 9.2 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFE42553.1 - 8.5e-05 22.2 0.0 0.00078 19.1 0.0 2.4 2 0 0 2 2 2 1 TPR repeat TPR_7 PF13176.6 EFE42553.1 - 0.00017 21.3 0.0 0.081 13.0 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFE42553.1 - 0.00065 19.5 0.2 23 5.0 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE42553.1 - 0.0026 18.0 0.0 2.8 8.2 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 EFE42553.1 - 0.0052 16.2 0.0 0.22 10.8 0.0 2.4 2 0 0 2 2 2 1 MalT-like TPR region TPR_21 PF09976.9 EFE42553.1 - 0.016 14.9 0.0 0.61 9.8 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain TPR_5 PF12688.7 EFE42553.1 - 0.026 14.7 0.2 0.24 11.6 0.0 2.5 2 1 0 3 3 2 0 Tetratrico peptide repeat TPR_17 PF13431.6 EFE42553.1 - 0.03 14.7 0.0 92 3.8 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFE42553.1 - 0.037 13.5 0.3 5.6 6.5 0.1 2.7 2 0 0 2 2 2 0 SHNi-TPR C_GCAxxG_C_C PF09719.10 EFE42553.1 - 0.1 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) TPR_4 PF07721.14 EFE42553.1 - 0.11 13.2 1.6 1.8 9.4 0.0 3.3 4 0 0 4 4 2 0 Tetratricopeptide repeat RWD PF05773.22 EFE42554.1 - 7.3e-27 94.0 1.4 1.5e-26 93.0 1.4 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 EFE42554.1 - 0.00014 22.2 15.3 0.00066 20.1 15.0 2.2 1 1 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 DUF1682 PF07946.14 EFE42554.1 - 0.00097 18.4 7.2 0.0013 18.0 7.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Pro-rich_19 PF15455.6 EFE42554.1 - 0.093 11.9 0.1 0.17 11.0 0.1 1.3 1 1 0 1 1 1 0 Proline-rich 19 DUF1485 PF07364.12 EFE42554.1 - 0.11 11.8 0.1 0.7 9.1 0.0 1.9 1 1 1 2 2 2 0 Metallopeptidase family M81 MPM1 PF17234.2 EFE42554.1 - 3.7 7.8 9.7 1.8 8.8 7.0 1.6 1 1 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Putative_PNPOx PF01243.20 EFE42555.1 - 3.9e-06 26.9 0.0 8.3e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase MTP18 PF10558.9 EFE42555.1 - 0.01 15.8 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) GST_C PF00043.25 EFE42556.1 - 2.7e-16 59.6 0.1 5.8e-16 58.5 0.1 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFE42556.1 - 3.8e-14 52.8 0.0 1.2e-13 51.2 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE42556.1 - 9.2e-11 41.9 0.0 1.7e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFE42556.1 - 1.4e-10 41.4 0.0 2.4e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFE42556.1 - 3.3e-08 33.4 0.4 9.4e-08 32.0 0.1 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFE42556.1 - 5.1e-08 33.0 0.0 9.4e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EFE42556.1 - 0.0023 18.5 0.0 0.0043 17.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Dodecin PF07311.12 EFE42557.1 - 0.12 12.6 0.1 0.22 11.8 0.1 1.4 1 0 0 1 1 1 0 Dodecin Sec7_N PF12783.7 EFE42558.1 - 1.8e-40 138.4 19.3 2e-39 135.0 5.2 5.0 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EFE42558.1 - 7.7e-29 100.6 3.3 7.7e-29 100.6 3.3 4.9 4 1 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 Mon2_C PF16206.5 EFE42558.1 - 3.6e-19 68.4 2.2 3.6e-19 68.4 2.2 2.6 3 0 0 3 3 3 1 C-terminal region of Mon2 protein DUF1981 PF09324.10 EFE42558.1 - 0.00051 19.9 2.6 0.024 14.5 0.0 4.9 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) Gly_acyl_tr_N PF06021.11 EFE42558.1 - 0.011 15.8 1.6 0.22 11.6 0.1 2.6 2 0 0 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase Antimicrobial19 PF08225.11 EFE42558.1 - 0.14 11.8 0.4 0.46 10.1 0.0 2.1 2 0 0 2 2 2 0 Pseudin antimicrobial peptide Ipi1_N PF12333.8 EFE42558.1 - 6.4 7.4 6.0 11 6.7 0.1 3.8 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation Vps26 PF03643.15 EFE42559.1 - 3.5e-112 373.9 0.4 2.6e-103 344.8 0.2 2.1 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EFE42559.1 - 0.0008 19.5 0.7 1.9 8.5 0.0 3.3 3 1 1 4 4 4 2 Arrestin (or S-antigen), N-terminal domain AAA_18 PF13238.6 EFE42560.1 - 4.5e-11 43.4 0.0 2.7e-10 40.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFE42560.1 - 2.1e-10 41.0 0.0 7.4e-10 39.2 0.0 2.0 2 1 0 2 2 1 1 AAA domain SKI PF01202.22 EFE42560.1 - 2.4e-10 40.7 0.1 3.1e-09 37.2 0.1 2.2 1 1 0 1 1 1 1 Shikimate kinase Rad17 PF03215.15 EFE42560.1 - 9.4e-07 28.9 0.0 1.8e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_17 PF13207.6 EFE42560.1 - 8.9e-06 26.2 0.0 0.0038 17.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 EFE42560.1 - 9.4e-06 25.6 0.0 0.12 12.2 0.0 2.2 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA PF00004.29 EFE42560.1 - 6.2e-05 23.4 0.0 0.00011 22.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFE42560.1 - 0.00024 21.1 0.0 0.00067 19.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFE42560.1 - 0.00035 20.9 0.1 0.00059 20.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EFE42560.1 - 0.00045 20.0 0.0 0.0012 18.6 0.0 1.7 2 0 0 2 2 2 1 Cytidylate kinase AAA_16 PF13191.6 EFE42560.1 - 0.00081 19.8 0.0 0.0013 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EFE42560.1 - 0.00091 19.2 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain RNA_helicase PF00910.22 EFE42560.1 - 0.0015 18.9 0.0 0.0032 17.8 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Cytidylate_kin2 PF13189.6 EFE42560.1 - 0.0021 18.2 0.0 0.021 15.0 0.0 2.1 2 0 0 2 2 2 1 Cytidylate kinase-like family APS_kinase PF01583.20 EFE42560.1 - 0.0037 17.2 0.0 0.014 15.3 0.0 1.8 1 1 0 1 1 1 1 Adenylylsulphate kinase AAA_28 PF13521.6 EFE42560.1 - 0.0041 17.4 0.0 0.0078 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EFE42560.1 - 0.0069 16.4 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 EFE42560.1 - 0.0095 15.7 0.1 0.021 14.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFE42560.1 - 0.01 14.9 0.0 0.02 14.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 EFE42560.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.6 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 EFE42560.1 - 0.011 15.0 0.0 0.048 12.9 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 EFE42560.1 - 0.014 15.1 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain tRNA_lig_kinase PF08303.11 EFE42560.1 - 0.015 15.4 0.0 0.035 14.2 0.0 1.6 2 0 0 2 2 1 0 tRNA ligase kinase domain PRK PF00485.18 EFE42560.1 - 0.015 15.1 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.27 EFE42560.1 - 0.016 15.7 0.0 0.03 14.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.16 EFE42560.1 - 0.022 14.2 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein Viral_helicase1 PF01443.18 EFE42560.1 - 0.03 14.0 0.0 0.067 12.9 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 EFE42560.1 - 0.036 13.6 0.1 0.19 11.2 0.0 2.1 2 1 0 2 2 2 0 P-loop containing dynein motor region Herpes_Helicase PF02689.14 EFE42560.1 - 0.042 11.8 0.0 0.057 11.3 0.0 1.1 1 0 0 1 1 1 0 Helicase DUF2075 PF09848.9 EFE42560.1 - 0.049 12.9 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 EFE42560.1 - 0.054 12.9 0.1 0.14 11.5 0.0 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EFE42560.1 - 0.054 13.2 0.0 0.086 12.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 EFE42560.1 - 0.054 13.4 0.0 0.18 11.7 0.1 1.7 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 EFE42560.1 - 0.066 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ADK PF00406.22 EFE42560.1 - 0.075 13.1 0.1 1.1 9.3 0.0 2.1 2 0 0 2 2 2 0 Adenylate kinase AAA_19 PF13245.6 EFE42560.1 - 0.092 13.1 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EFE42560.1 - 0.097 11.8 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain CoaE PF01121.20 EFE42560.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_25 PF13481.6 EFE42560.1 - 0.11 12.1 0.1 0.21 11.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EFE42560.1 - 0.16 11.7 0.0 0.5 10.1 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Acetyltransf_3 PF13302.7 EFE42561.1 - 4.7e-14 53.2 0.0 5.8e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Peptidase_C14 PF00656.22 EFE42562.1 - 4.6e-57 193.8 0.0 6.3e-57 193.4 0.0 1.1 1 0 0 1 1 1 1 Caspase domain 2-oxoacid_dh PF00198.23 EFE42563.1 - 9.4e-82 273.9 0.7 1.2e-81 273.6 0.7 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.17 EFE42563.1 - 9.5e-14 51.5 0.0 2.3e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl PF00364.22 EFE42563.1 - 3e-12 46.2 0.0 6.9e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Phage_spike PF18715.1 EFE42563.1 - 0.72 10.0 5.1 0.23 11.5 0.5 2.3 2 0 0 2 2 2 0 Phage spike trimer PI-PLC-X PF00388.19 EFE42564.1 - 6.7e-11 42.0 0.0 1.1e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain DUF1598 PF07643.11 EFE42565.1 - 0.079 13.2 0.1 0.17 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1598) Ribosomal_L10 PF00466.20 EFE42565.1 - 0.086 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L10 Methyltransf_14 PF08484.11 EFE42566.1 - 0.072 12.9 0.1 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 C-methyltransferase C-terminal domain F-box PF00646.33 EFE42566.1 - 0.094 12.6 0.5 0.28 11.1 0.2 1.9 2 0 0 2 2 2 0 F-box domain Lipase_GDSL_2 PF13472.6 EFE42568.1 - 3.5e-13 50.3 0.2 9.6e-12 45.7 0.2 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFE42568.1 - 1.8e-05 24.8 0.0 3.1e-05 24.1 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Hexokinase_1 PF00349.21 EFE42570.1 - 1.2e-61 208.2 0.0 1.6e-61 207.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EFE42570.1 - 1.1e-43 149.5 0.0 4.1e-43 147.5 0.0 1.9 1 1 0 1 1 1 1 Hexokinase GILT PF03227.16 EFE42571.1 - 6.4e-15 55.3 1.6 7.5e-14 51.9 1.2 2.5 1 1 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) MFS_1 PF07690.16 EFE42573.1 - 3.6e-32 111.7 25.2 3.6e-32 111.7 25.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily GCP_N_terminal PF17681.1 EFE42574.1 - 4.4e-29 102.1 0.0 2e-28 99.9 0.0 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFE42574.1 - 6.6e-25 88.2 0.0 1e-24 87.6 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal ThiF PF00899.21 EFE42575.1 - 3.2e-108 360.7 0.0 4.2e-75 252.2 0.0 2.2 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EFE42575.1 - 3.6e-96 321.9 1.3 2.1e-95 319.4 0.8 2.1 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EFE42575.1 - 2.5e-30 104.5 0.1 5.4e-30 103.4 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 EFE42575.1 - 8.5e-29 100.1 0.0 1.7e-28 99.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 EFE42575.1 - 1.1e-22 80.0 1.5 1.1e-22 80.0 1.5 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle GST_N_2 PF13409.6 EFE42576.1 - 8.2e-23 80.5 0.1 2.8e-22 78.8 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFE42576.1 - 5.3e-13 48.8 0.0 1e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFE42576.1 - 6.8e-06 26.4 0.1 0.00031 21.1 0.1 2.4 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFE42576.1 - 2.1e-05 24.7 0.0 6.6e-05 23.0 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain EF-hand_7 PF13499.6 EFE42577.1 - 2.1e-21 76.2 4.8 2.1e-11 44.1 0.4 2.6 2 1 0 2 2 2 2 EF-hand domain pair Mito_carr PF00153.27 EFE42577.1 - 8.8e-20 70.4 0.2 1.4e-19 69.8 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial carrier protein EF-hand_1 PF00036.32 EFE42577.1 - 1.9e-18 64.5 4.0 1.5e-05 24.2 0.2 4.3 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 EFE42577.1 - 3.6e-18 64.2 2.8 1.5e-05 24.2 0.2 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EFE42577.1 - 6.8e-17 59.9 6.4 2.3e-05 24.0 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFE42577.1 - 1.1e-10 41.1 5.0 7.1e-05 22.6 0.2 3.9 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFE42577.1 - 4.7e-10 39.8 0.3 8.3e-06 26.1 0.1 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFE42577.1 - 0.00032 20.6 3.0 0.073 13.0 0.3 3.1 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 EFE42577.1 - 0.00059 19.6 0.2 1.5 8.7 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 EFE42577.1 - 0.0071 16.6 0.0 12 6.4 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EFE42578.1 - 0.0099 16.3 0.2 0.013 15.9 0.2 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFE42578.1 - 0.099 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain Cyclin_N PF00134.23 EFE42579.1 - 1.4e-10 41.0 0.1 2.8e-10 40.0 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EFE42579.1 - 0.071 13.5 0.1 0.2 12.0 0.0 1.8 2 0 0 2 2 2 0 Cyclin C-terminal domain Ribosomal_60s PF00428.19 EFE42579.1 - 0.24 12.0 1.6 0.59 10.8 1.6 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF4452 PF14618.6 EFE42580.1 - 3.7e-51 173.4 9.3 3.7e-51 173.4 9.3 2.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4452) Zip PF02535.22 EFE42580.1 - 0.01 15.1 12.7 0.013 14.7 12.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 EFE42580.1 - 0.095 11.2 7.4 0.1 11.2 7.4 1.2 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 EFE42580.1 - 0.14 9.3 8.6 0.17 9.0 8.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF702 PF05142.12 EFE42580.1 - 0.5 10.8 9.1 0.94 9.9 9.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF702) PAT1 PF09770.9 EFE42580.1 - 1.3 7.2 16.1 1.8 6.7 16.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Apt1 PF10351.9 EFE42580.1 - 3.1 6.5 8.3 3.7 6.3 8.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 EFE42580.1 - 8.3 5.9 10.7 15 5.1 10.7 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PT PF04886.12 EFE42581.1 - 9.1 5.9 19.2 0.18 11.4 1.1 3.1 3 1 0 3 3 3 0 PT repeat zf-met2 PF12907.7 EFE42583.1 - 0.016 15.3 0.1 0.034 14.3 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding Chal_sti_synt_C PF02797.15 EFE42584.1 - 4.7e-18 65.6 0.0 7.8e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EFE42584.1 - 1.7e-14 53.8 0.1 3e-14 53.0 0.1 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III_C PF08541.10 EFE42584.1 - 0.00013 22.0 0.0 0.0014 18.8 0.0 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal MFS_1 PF07690.16 EFE42585.1 - 7.6e-28 97.4 32.0 2.3e-26 92.6 23.7 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE42585.1 - 9.5e-07 28.0 2.8 9.5e-07 28.0 2.8 2.9 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFE42585.1 - 0.00043 18.8 1.4 0.00097 17.7 1.4 1.7 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF347 PF03988.12 EFE42585.1 - 0.099 12.8 0.7 0.099 12.8 0.7 3.5 4 0 0 4 4 4 0 Repeat of Unknown Function (DUF347) UL42 PF17638.2 EFE42585.1 - 1.3 9.0 6.9 3.1 7.8 0.5 3.1 2 1 1 3 3 3 0 HCMV UL42 Pkr1 PF08636.10 EFE42585.1 - 1.3 9.2 9.1 0.21 11.8 3.4 2.5 2 0 0 2 2 2 0 ER protein Pkr1 SNARE PF05739.19 EFE42586.1 - 6.4e-10 38.9 0.1 1.2e-09 38.0 0.1 1.5 1 0 0 1 1 1 1 SNARE domain DUF1676 PF07898.13 EFE42586.1 - 0.019 15.0 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) Spectrin PF00435.21 EFE42586.1 - 0.046 14.2 0.9 0.22 12.0 0.0 2.2 2 0 0 2 2 2 0 Spectrin repeat zf-TRAF_2 PF15965.5 EFE42587.1 - 6.5e-08 32.9 2.3 1.1e-07 32.3 2.3 1.3 1 0 0 1 1 1 1 TRAF-like zinc-finger zf-TRAF PF02176.18 EFE42587.1 - 0.00011 22.9 13.5 0.002 18.8 4.4 1.6 1 1 1 2 2 2 2 TRAF-type zinc finger Sina PF03145.16 EFE42587.1 - 0.012 15.5 2.7 0.015 15.3 0.7 1.9 1 1 1 2 2 2 0 Seven in absentia protein family RasGAP_C PF03836.15 EFE42587.1 - 0.022 14.9 0.5 0.089 12.9 0.0 2.1 2 1 0 2 2 2 0 RasGAP C-terminus TSC22 PF01166.18 EFE42587.1 - 0.025 14.9 2.4 2.5 8.5 0.1 2.9 3 0 0 3 3 3 0 TSC-22/dip/bun family DUF3972 PF13118.6 EFE42587.1 - 0.038 14.4 0.2 0.23 11.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) DivIC PF04977.15 EFE42587.1 - 0.043 13.6 0.2 1.4 8.7 0.0 2.5 3 0 0 3 3 3 0 Septum formation initiator CENP-F_leu_zip PF10473.9 EFE42587.1 - 0.11 12.5 1.2 1 9.4 0.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PspA_IM30 PF04012.12 EFE42587.1 - 0.18 11.3 1.8 7.2 6.1 0.3 2.2 2 0 0 2 2 2 0 PspA/IM30 family DUF2730 PF10805.8 EFE42587.1 - 0.22 11.6 1.8 2.6 8.2 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) GIT_CC PF16559.5 EFE42587.1 - 0.76 9.7 3.7 0.8 9.6 0.3 2.4 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Prominin PF05478.11 EFE42587.1 - 1 7.3 3.4 1.3 6.9 0.2 1.9 1 1 0 2 2 2 0 Prominin TMF_DNA_bd PF12329.8 EFE42587.1 - 4.1 7.5 5.8 1.1 9.3 0.4 2.4 3 0 0 3 3 2 0 TATA element modulatory factor 1 DNA binding Het-C PF07217.11 EFE42589.1 - 2.6e-276 917.6 0.0 3.2e-276 917.3 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C TctA PF01970.16 EFE42589.1 - 1.7 7.3 3.4 0.51 9.0 0.3 1.6 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctA family Defensin_2 PF01097.18 EFE42590.1 - 4e-10 39.4 4.6 5.6e-10 39.0 4.6 1.2 1 0 0 1 1 1 1 Arthropod defensin Toxin_38 PF14866.6 EFE42590.1 - 0.00016 21.9 0.3 0.00019 21.7 0.3 1.1 1 0 0 1 1 1 1 Potassium channel toxin UPF0449 PF15136.6 EFE42591.1 - 0.11 13.0 3.5 0.23 12.0 3.5 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 UPF0242 PF06785.11 EFE42591.1 - 0.27 11.3 8.2 0.19 11.8 6.6 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Med4 PF10018.9 EFE42591.1 - 0.68 9.6 9.4 0.3 10.7 6.4 1.8 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4375 PF14300.6 EFE42591.1 - 1.3 9.3 3.9 14 6.0 3.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) ATP-synt_B PF00430.18 EFE42591.1 - 6.4 6.9 15.1 0.15 12.1 8.1 1.9 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) Ank_2 PF12796.7 EFE42592.1 - 2e-44 150.1 0.1 2.4e-11 44.0 0.0 8.6 8 0 0 8 8 8 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE42592.1 - 2.9e-35 120.2 2.7 1.4e-05 25.5 0.0 11.1 10 2 2 12 12 12 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE42592.1 - 5.8e-31 103.1 6.2 0.0064 16.9 0.1 12.7 14 0 0 14 14 14 8 Ankyrin repeat Ank_5 PF13857.6 EFE42592.1 - 3.1e-28 97.4 11.7 6.5e-06 26.3 0.0 11.1 11 0 0 11 11 11 4 Ankyrin repeats (many copies) Ank PF00023.30 EFE42592.1 - 3.4e-24 84.2 10.3 0.00065 20.0 0.1 10.3 12 1 0 12 12 12 6 Ankyrin repeat Polbeta PF18765.1 EFE42592.1 - 0.052 13.6 0.1 0.21 11.7 0.1 2.1 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase XPG_I_2 PF12813.7 EFE42592.1 - 0.081 12.4 0.3 58 3.0 0.0 3.3 3 0 0 3 3 3 0 XPG domain containing IBN_N PF03810.19 EFE42593.1 - 2.2e-10 40.3 0.8 9.4e-09 35.1 0.1 3.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFE42593.1 - 2.8e-05 24.2 0.1 0.00089 19.3 0.1 3.1 2 1 0 2 2 2 1 Exportin 1-like protein Proteasom_PSMB PF10508.9 EFE42593.1 - 0.00036 19.2 0.9 0.0081 14.7 0.0 2.9 3 0 0 3 3 3 1 Proteasome non-ATPase 26S subunit RIX1 PF08167.12 EFE42593.1 - 0.00057 19.7 3.2 0.023 14.4 0.0 3.9 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis CAS_CSE1 PF03378.15 EFE42593.1 - 0.0018 16.9 0.1 0.0083 14.7 0.0 2.1 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus HORMA PF02301.18 EFE42595.1 - 1.6e-10 41.0 0.0 2e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 HORMA domain NAD_binding_2 PF03446.15 EFE42595.1 - 0.071 13.3 0.1 0.11 12.7 0.1 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase IBR PF01485.21 EFE42596.1 - 7e-09 35.8 27.3 6.2e-08 32.7 7.8 3.6 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain Pkinase PF00069.25 EFE42597.1 - 2.3e-19 69.8 0.0 3.8e-19 69.1 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42597.1 - 5.4e-10 39.0 0.0 9.6e-10 38.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE42597.1 - 0.0022 16.9 0.0 0.0031 16.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFE42597.1 - 0.037 13.4 0.0 0.25 10.7 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4901 PF16244.5 EFE42597.1 - 0.13 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4901) Pox_ser-thr_kin PF05445.11 EFE42597.1 - 0.21 10.5 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Acetyltransf_7 PF13508.7 EFE42598.1 - 0.00035 21.0 0.0 0.00064 20.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE42598.1 - 0.0049 16.9 0.0 0.011 15.8 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFE42598.1 - 0.049 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFE42598.1 - 0.085 12.8 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Pro_dh PF01619.18 EFE42599.1 - 3.1e-65 220.6 4.0 4e-65 220.3 4.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase Hydrolase PF00702.26 EFE42599.1 - 0.064 13.5 0.4 3.9 7.7 0.1 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Wyosine_form PF08608.12 EFE42600.1 - 5.3e-22 77.9 0.0 1.1e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 EFE42600.1 - 1.3e-21 77.6 0.0 4.1e-21 76.1 0.0 1.9 1 1 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 EFE42600.1 - 4.7e-08 33.3 0.3 3.2e-06 27.4 0.3 2.4 1 1 0 1 1 1 1 Flavodoxin MFS_1 PF07690.16 EFE42601.1 - 1.6e-45 155.6 42.7 1.6e-45 155.6 42.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily FPN1 PF06963.12 EFE42601.1 - 5.4e-05 22.0 0.0 0.00014 20.5 0.0 1.6 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Sugar_tr PF00083.24 EFE42601.1 - 0.00078 18.4 26.0 0.0075 15.2 26.0 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter OAR PF03826.17 EFE42604.1 - 1.6 8.7 6.2 1.6 8.7 0.3 2.5 2 0 0 2 2 2 0 OAR domain GWT1 PF06423.12 EFE42605.1 - 1.1e-38 132.6 4.4 2.8e-38 131.4 2.2 2.6 2 0 0 2 2 2 1 GWT1 DUF4818 PF16089.5 EFE42605.1 - 0.088 13.3 0.0 0.088 13.3 0.0 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4818) Amidase PF01425.21 EFE42606.1 - 7.4e-78 262.5 0.1 3e-77 260.5 0.1 1.7 1 1 0 1 1 1 1 Amidase DnaJ PF00226.31 EFE42607.1 - 2.6e-16 59.5 0.6 6.4e-16 58.2 0.6 1.7 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EFE42607.1 - 2.3e-13 49.9 0.0 2.3e-12 46.6 0.0 2.1 1 1 0 1 1 1 1 Sec63 Brl domain DUF2749 PF10907.8 EFE42608.1 - 0.12 12.5 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) Peptidase_M24 PF00557.24 EFE42609.1 - 7.8e-53 179.3 0.0 1e-52 178.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFE42609.1 - 8.2e-23 80.5 0.0 1.5e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DNA_pol_phi PF04931.13 EFE42610.1 - 8.6 4.3 6.7 8.6 4.3 6.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi zf-C2H2 PF00096.26 EFE42611.1 - 1.6e-05 25.1 2.4 0.059 13.8 0.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE42611.1 - 0.0038 17.9 5.3 0.79 10.7 0.0 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger Zn_ribbon_recom PF13408.6 EFE42611.1 - 0.072 13.6 0.4 0.15 12.6 0.4 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain F-box-like PF12937.7 EFE42612.1 - 0.0001 22.1 1.2 0.00043 20.1 0.0 2.6 2 1 1 3 3 3 1 F-box-like F-box PF00646.33 EFE42612.1 - 0.0049 16.7 0.0 0.019 14.9 0.0 2.0 1 0 0 1 1 1 1 F-box domain MTS PF05175.14 EFE42613.1 - 0.0017 18.0 0.0 0.79 9.2 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase small domain Methyltransf_12 PF08242.12 EFE42613.1 - 0.14 12.9 0.0 0.27 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EFE42613.1 - 0.16 12.7 0.0 0.3 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TauD PF02668.16 EFE42614.1 - 4.2e-30 105.5 0.0 5.5e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TSSC4 PF15264.6 EFE42614.1 - 0.086 13.1 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Tumour suppressing sub-chromosomal transferable candidate 4 Fungal_lectin PF07938.12 EFE42615.1 - 5.3e-44 150.8 0.1 5.8e-44 150.7 0.1 1.0 1 0 0 1 1 1 1 Fungal fucose-specific lectin Mito_carr PF00153.27 EFE42616.1 - 8.1e-60 198.8 2.1 2e-21 75.7 0.2 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein F-box-like PF12937.7 EFE42617.1 - 4.6e-08 32.8 0.6 1.4e-07 31.3 0.6 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE42617.1 - 1.7e-06 27.8 0.5 3.9e-06 26.6 0.5 1.6 1 0 0 1 1 1 1 F-box domain Med15 PF09606.10 EFE42618.1 - 0.48 9.0 9.8 0.5 9.0 9.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Endonuc_Holl PF10107.9 EFE42618.1 - 0.74 9.7 3.1 0.86 9.4 3.1 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase RNA_pol_Rpc4 PF05132.14 EFE42618.1 - 0.81 10.1 4.3 0.98 9.8 4.3 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nop53 PF07767.11 EFE42618.1 - 1.1 8.6 9.3 1.1 8.6 9.3 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) FYDLN_acid PF09538.10 EFE42618.1 - 1.2 9.8 7.0 1.5 9.5 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) PepSY_TM PF03929.16 EFE42618.1 - 1.3 8.6 5.4 1.5 8.4 5.4 1.0 1 0 0 1 1 1 0 PepSY-associated TM region Pex19 PF04614.12 EFE42618.1 - 1.6 8.4 8.6 1.7 8.3 8.6 1.0 1 0 0 1 1 1 0 Pex19 protein family DUF853 PF05872.12 EFE42618.1 - 1.6 7.2 8.4 1.8 7.1 8.4 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) CCDC53 PF10152.9 EFE42618.1 - 7.3 7.0 8.3 9.1 6.7 8.3 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Presenilin PF01080.17 EFE42618.1 - 9.1 4.9 6.0 9.4 4.9 6.0 1.0 1 0 0 1 1 1 0 Presenilin SNF2_N PF00176.23 EFE42619.1 - 1.6e-20 73.1 0.0 2.2e-17 62.8 0.0 2.6 2 0 0 2 2 2 2 SNF2 family N-terminal domain ResIII PF04851.15 EFE42619.1 - 0.00074 19.6 0.0 0.0021 18.1 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ANAPC2 PF08672.11 EFE42620.1 - 1.9e-22 79.5 0.3 5.6e-22 78.0 0.3 1.9 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 Cullin PF00888.22 EFE42620.1 - 3.9e-22 78.6 0.1 7.6e-22 77.7 0.1 1.3 1 0 0 1 1 1 1 Cullin family DUF3235 PF11574.8 EFE42620.1 - 0.4 11.6 5.9 0.95 10.4 5.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) Pkr1 PF08636.10 EFE42621.1 - 2.6e-29 101.2 4.0 4.9e-29 100.3 4.0 1.5 1 0 0 1 1 1 1 ER protein Pkr1 GTP_EFTU PF00009.27 EFE42621.1 - 4.6e-09 36.1 0.0 1.3e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFE42621.1 - 0.0031 17.4 0.4 0.57 10.1 0.2 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EFE42621.1 - 0.0042 17.6 0.0 0.011 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFE42621.1 - 0.012 16.1 0.0 0.04 14.4 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EFE42621.1 - 0.023 15.1 0.1 0.09 13.2 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EFE42621.1 - 0.035 13.9 0.4 0.086 12.6 0.4 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EFE42621.1 - 0.065 12.6 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 EFE42621.1 - 0.17 12.0 0.1 0.78 9.8 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase RAB3GAP2_C PF14656.6 EFE42622.1 - 0.0036 15.6 1.9 0.016 13.4 1.9 1.8 1 1 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus SID-1_RNA_chan PF13965.6 EFE42622.1 - 0.029 12.8 0.5 0.033 12.6 0.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NPR3 PF03666.13 EFE42622.1 - 0.18 10.6 25.8 0.23 10.2 25.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC27 PF09507.10 EFE42622.1 - 0.25 10.7 36.1 0.33 10.3 36.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 ALMT PF11744.8 EFE42622.1 - 1.1 8.1 13.5 1.3 7.7 13.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter U79_P34 PF03064.16 EFE42622.1 - 1.3 8.4 32.6 1.8 7.9 32.6 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 PPP4R2 PF09184.11 EFE42622.1 - 1.7 8.2 27.3 2.2 7.8 27.3 1.1 1 0 0 1 1 1 0 PPP4R2 Raftlin PF15250.6 EFE42622.1 - 2.1 7.0 15.9 2.6 6.7 15.9 1.1 1 0 0 1 1 1 0 Raftlin MDM1 PF15501.6 EFE42622.1 - 2.1 7.4 33.2 2.6 7.1 33.2 1.0 1 0 0 1 1 1 0 Nuclear protein MDM1 Pox_Ag35 PF03286.14 EFE42622.1 - 2.3 8.0 32.7 3.5 7.4 32.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2052 PF09747.9 EFE42622.1 - 2.5 8.2 35.5 3.7 7.6 35.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) NOA36 PF06524.12 EFE42622.1 - 3.5 6.9 19.4 4.9 6.4 19.4 1.2 1 0 0 1 1 1 0 NOA36 protein RR_TM4-6 PF06459.12 EFE42622.1 - 4.6 7.0 36.1 6.3 6.5 36.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Trypan_PARP PF05887.11 EFE42622.1 - 8.6 6.3 26.6 14 5.6 26.6 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Endostatin PF06482.11 EFE42622.1 - 9.5 5.6 13.6 12 5.2 13.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CENP-N PF05238.13 EFE42622.1 - 9.8 5.4 18.1 14 4.8 18.1 1.2 1 0 0 1 1 1 0 Kinetochore protein CHL4 like RUN PF02759.19 EFE42623.1 - 0.097 12.6 0.0 0.17 11.8 0.0 1.4 2 0 0 2 2 2 0 RUN domain JAKMIP_CC3 PF16034.5 EFE42625.1 - 0.21 11.5 2.6 0.58 10.1 2.6 1.7 1 0 0 1 1 1 0 JAKMIP CC3 domain FOG_N PF15888.5 EFE42625.1 - 0.23 11.8 3.0 0.78 10.1 3.0 1.9 1 0 0 1 1 1 0 Folded gastrulation N-terminus Arf PF00025.21 EFE42626.1 - 3.1e-74 248.2 1.5 1.4e-73 246.0 1.5 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFE42626.1 - 7.3e-14 52.0 0.1 1e-13 51.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFE42626.1 - 5.9e-13 48.6 0.0 7.9e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFE42626.1 - 2.5e-12 46.6 2.0 1.5e-08 34.2 0.5 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFE42626.1 - 1.5e-11 44.1 0.0 1.9e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFE42626.1 - 1.7e-08 34.1 0.2 3.1e-08 33.3 0.2 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFE42626.1 - 7.3e-06 26.1 0.1 1e-05 25.5 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase CRISPR_Cas2 PF09827.9 EFE42626.1 - 0.027 14.6 0.0 0.049 13.8 0.0 1.4 1 0 0 1 1 1 0 CRISPR associated protein Cas2 6PF2K PF01591.18 EFE42626.1 - 0.054 12.8 0.5 0.13 11.6 0.5 1.7 1 1 0 1 1 1 0 6-phosphofructo-2-kinase Acetyltransf_1 PF00583.25 EFE42627.1 - 1.1e-11 45.0 0.0 1.5e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFE42627.1 - 1.2e-07 32.0 0.0 2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFE42627.1 - 4e-07 30.0 0.0 2e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE42627.1 - 5.5e-07 29.5 0.0 2.2e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 EFE42627.1 - 0.0018 19.0 0.1 0.0034 18.0 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFE42627.1 - 0.011 15.9 0.0 0.03 14.4 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.6 EFE42627.1 - 0.022 14.4 0.0 0.048 13.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ribosomal_L1 PF00687.21 EFE42628.1 - 3.4e-41 141.2 1.5 8.1e-40 136.7 1.5 2.0 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3593 PF12159.8 EFE42629.1 - 0.1 12.6 0.1 0.23 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3593) WH2 PF02205.20 EFE42630.1 - 8.7e-10 38.1 0.3 8.7e-10 38.1 0.3 1.9 2 0 0 2 2 2 1 WH2 motif SURF4 PF02077.15 EFE42632.1 - 4.7e-72 242.8 12.5 5.7e-72 242.5 12.5 1.0 1 0 0 1 1 1 1 SURF4 family DUF1405 PF07187.11 EFE42632.1 - 0.0035 17.3 2.6 0.0035 17.3 2.6 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1405) UPF0139 PF03669.13 EFE42632.1 - 0.023 14.6 0.8 0.023 14.6 0.8 2.5 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0139) Oxidored_q2 PF00420.24 EFE42634.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Amidase PF01425.21 EFE42635.1 - 1.6e-95 320.7 0.0 3.2e-95 319.8 0.0 1.4 1 1 0 1 1 1 1 Amidase Glycos_transf_1 PF00534.20 EFE42636.1 - 5.3e-13 48.9 0.0 9.3e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFE42636.1 - 1.9e-07 31.5 0.0 4.2e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EFE42636.1 - 0.024 15.0 0.0 0.078 13.4 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferases group 1 HLH PF00010.26 EFE42638.1 - 4.2e-14 52.3 0.7 9.8e-14 51.1 0.7 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain YDG PF18657.1 EFE42638.1 - 0.064 13.5 1.2 0.15 12.2 1.2 1.5 1 0 0 1 1 1 0 YDG domain Spt20 PF12090.8 EFE42638.1 - 1.6 8.2 29.5 0.08 12.5 23.5 1.8 2 0 0 2 2 2 0 Spt20 family PGA2 PF07543.12 EFE42638.1 - 2.5 8.1 9.2 4.7 7.2 9.2 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 ALMT PF11744.8 EFE42638.1 - 3.6 6.3 5.1 5.9 5.6 5.1 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter IU_nuc_hydro PF01156.19 EFE42639.1 - 7.5e-57 193.2 0.0 1.1e-56 192.7 0.0 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Transketolase_C PF02780.20 EFE42639.1 - 0.00017 21.5 0.2 0.044 13.7 0.0 2.6 2 0 0 2 2 2 2 Transketolase, C-terminal domain Fungal_trans PF04082.18 EFE42641.1 - 2.3e-17 62.9 3.1 3.7e-17 62.3 3.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE42641.1 - 7.5e-08 32.4 9.2 1.6e-07 31.3 9.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NIP_1 PF08995.10 EFE42641.1 - 0.24 11.8 4.5 56 4.2 0.0 2.8 2 1 0 2 2 2 0 Necrosis inducing protein-1 p450 PF00067.22 EFE42642.1 - 1.4e-14 53.8 0.1 1.4e-14 53.8 0.1 1.2 1 1 0 1 1 1 1 Cytochrome P450 DUF1933 PF09147.10 EFE42642.1 - 0.0084 15.7 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1933) Arylsulfotran_2 PF14269.6 EFE42643.1 - 5.4e-109 364.2 2.4 8e-109 363.6 2.4 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) CHASE4 PF05228.13 EFE42643.1 - 0.097 12.9 0.0 0.23 11.7 0.0 1.6 1 1 0 1 1 1 0 CHASE4 domain p450 PF00067.22 EFE42644.1 - 3.7e-63 213.9 0.0 4.8e-63 213.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S8 PF00082.22 EFE42645.1 - 5.5e-27 94.8 13.5 9.8e-27 94.0 13.5 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE42645.1 - 1.1e-14 54.9 0.0 2e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_M14 PF00246.24 EFE42646.1 - 2.9e-80 270.2 0.0 3.7e-80 269.8 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EFE42646.1 - 6e-11 42.6 0.1 1.6e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 Carboxypeptidase activation peptide Cellulase PF00150.18 EFE42646.1 - 0.058 12.8 0.0 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) AstE_AspA PF04952.14 EFE42646.1 - 0.18 10.9 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Fungal_trans PF04082.18 EFE42647.1 - 1.5e-14 53.7 0.1 2.5e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain SOG2 PF10428.9 EFE42647.1 - 0.042 13.1 6.1 0.072 12.3 6.1 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein GARP PF16731.5 EFE42647.1 - 0.19 11.4 0.5 0.33 10.6 0.5 1.3 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma Rox3 PF08633.10 EFE42648.1 - 2.9e-66 223.7 0.2 2.9e-66 223.7 0.2 2.0 2 1 0 3 3 3 1 Rox3 mediator complex subunit HAD_2 PF13419.6 EFE42649.1 - 4.5e-08 33.4 0.0 1.7e-07 31.5 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFE42649.1 - 5.2e-07 30.2 0.0 6.6e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE42649.1 - 0.031 14.3 0.0 0.06 13.4 0.0 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like Thr_synth_N PF14821.6 EFE42650.1 - 4.5e-28 97.3 0.0 1.3e-27 95.8 0.0 1.9 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 EFE42650.1 - 7.1e-16 58.5 0.0 5.7e-15 55.5 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4202 PF13875.6 EFE42651.1 - 9.6e-79 263.6 3.5 1.1e-78 263.5 3.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) 2-ph_phosp PF04029.14 EFE42651.1 - 0.089 11.9 0.4 2.7 7.1 0.2 2.2 2 0 0 2 2 2 0 2-phosphosulpholactate phosphatase VIT1 PF01988.19 EFE42652.1 - 3.8e-60 203.4 3.5 4.4e-60 203.2 3.5 1.0 1 0 0 1 1 1 1 VIT family VPS9 PF02204.18 EFE42654.1 - 9.2e-21 74.0 0.0 1.9e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EFE42654.1 - 8.9e-17 61.2 0.1 2.9e-16 59.5 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EFE42654.1 - 0.00013 21.6 0.2 0.0037 16.9 0.0 2.5 2 0 0 2 2 2 1 CUE domain Asn_synthase PF00733.21 EFE42655.1 - 2.3e-15 57.1 0.8 2.5e-05 24.1 0.0 3.1 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 EFE42655.1 - 7.7e-08 32.3 0.0 2.4e-07 30.7 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EFE42655.1 - 0.0053 16.2 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein GATase_6 PF13522.6 EFE42655.1 - 0.012 15.8 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferase domain NAD_synthase PF02540.17 EFE42655.1 - 0.2 10.7 0.0 0.45 9.6 0.0 1.6 2 0 0 2 2 2 0 NAD synthase bZIP_1 PF00170.21 EFE42656.1 - 1.7e-07 31.2 7.7 3.6e-07 30.2 7.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EFE42656.1 - 1.7e-07 31.2 8.2 4e-07 30.0 8.2 1.6 1 0 0 1 1 1 1 Basic region leucine zipper Sugarporin_N PF11471.8 EFE42656.1 - 0.015 15.2 5.2 0.046 13.7 5.2 1.8 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension bZIP_Maf PF03131.17 EFE42656.1 - 0.033 14.7 7.1 0.085 13.4 7.1 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF4094 PF13334.6 EFE42656.1 - 0.17 12.3 0.6 0.38 11.2 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) AlaDh_PNT_N PF05222.15 EFE42657.1 - 7.4e-40 136.4 0.0 9.2e-40 136.1 0.0 1.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB PF02233.16 EFE42658.1 - 4.3e-165 550.1 36.9 1.8e-161 538.1 26.2 2.9 2 1 0 3 3 3 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EFE42658.1 - 9.9e-66 221.1 0.3 9.9e-66 221.1 0.3 2.0 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EFE42658.1 - 5.1e-37 127.2 0.0 1.5e-36 125.7 0.0 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EFE42658.1 - 4.3e-30 104.0 3.0 4.3e-30 104.0 3.0 5.0 3 1 1 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EFE42658.1 - 0.003 16.9 1.2 1.1 8.6 0.1 3.4 2 1 1 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EFE42658.1 - 0.038 13.2 0.7 0.072 12.3 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 EFE42658.1 - 0.073 13.1 0.5 0.27 11.2 0.1 2.2 2 0 0 2 2 2 0 Zinc-binding dehydrogenase GIDA PF01134.22 EFE42658.1 - 0.097 11.7 0.8 0.17 10.9 0.8 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A TPP_enzyme_M PF00205.22 EFE42658.1 - 0.22 11.2 2.9 0.36 10.6 0.4 2.7 3 1 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain NAD_binding_8 PF13450.6 EFE42658.1 - 7.2 6.9 7.8 0.57 10.5 1.3 2.8 2 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain PH_6 PF15406.6 EFE42659.1 - 1e-35 122.4 2.8 1e-35 122.4 2.8 3.5 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.29 EFE42659.1 - 2.8e-09 37.4 0.0 9.3e-09 35.8 0.0 2.0 1 0 0 1 1 1 1 PH domain Sulfate_transp PF00916.20 EFE42660.1 - 1.5e-60 204.9 22.3 1.5e-60 204.9 22.3 1.4 2 0 0 2 2 2 1 Sulfate permease family cNMP_binding PF00027.29 EFE42660.1 - 1.6e-13 50.5 0.0 3.5e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 EFE42660.1 - 2.7e-11 43.1 0.1 5e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 STAS domain Sld5 PF05916.11 EFE42661.1 - 1e-12 48.5 0.2 2.5e-12 47.2 0.1 1.7 1 1 1 2 2 2 2 GINS complex protein INT_SG_DDX_CT_C PF15300.6 EFE42661.1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus HMG_box PF00505.19 EFE42662.1 - 2.2e-09 37.6 0.4 4.7e-09 36.5 0.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box PAXIP1_C PF15364.6 EFE42662.1 - 0.018 15.3 1.1 0.037 14.3 1.1 1.5 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein PHD PF00628.29 EFE42664.1 - 1.1e-08 34.8 10.1 1.1e-08 34.8 10.1 2.1 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 EFE42664.1 - 0.0015 18.0 5.4 0.0015 18.0 5.4 1.9 2 0 0 2 2 2 1 PHD-finger DUF2252 PF10009.9 EFE42664.1 - 3.5 6.6 12.7 1.9 7.5 10.1 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) Rcd1 PF04078.13 EFE42666.1 - 2.5e-116 387.5 5.4 1.7e-107 358.5 3.5 2.1 2 0 0 2 2 2 2 Cell differentiation family, Rcd1-like Lin-8 PF03353.15 EFE42666.1 - 0.16 11.5 11.0 0.21 11.1 11.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist EPL1 PF10513.9 EFE42666.1 - 0.44 10.9 4.6 0.68 10.3 4.6 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like PAT1 PF09770.9 EFE42666.1 - 1.8 6.7 16.8 2.2 6.5 16.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4407 PF14362.6 EFE42666.1 - 3.5 6.9 8.8 5.9 6.1 8.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TFIIA PF03153.13 EFE42666.1 - 8.1 6.3 27.4 11 5.9 27.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ThylakoidFormat PF11264.8 EFE42666.1 - 8.3 6.0 9.5 48 3.5 8.4 2.4 3 0 0 3 3 3 0 Thylakoid formation protein DUF4690 PF15756.5 EFE42667.1 - 0.011 16.3 1.6 0.035 14.7 1.6 1.9 1 0 0 1 1 1 0 Small Novel Rich in Cartilage DUF4834 PF16118.5 EFE42667.1 - 0.029 15.3 0.0 2 9.4 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) TMEM51 PF15345.6 EFE42667.1 - 0.038 13.8 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 Menin PF05053.13 EFE42670.1 - 0.0085 14.5 7.9 0.0085 14.5 7.9 1.0 1 0 0 1 1 1 1 Menin Secretin_N_2 PF07655.13 EFE42670.1 - 0.6 10.7 21.4 1.2 9.7 21.4 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain Presenilin PF01080.17 EFE42670.1 - 1.3 7.7 2.8 1.2 7.8 2.8 1.1 1 0 0 1 1 1 0 Presenilin PCI PF01399.27 EFE42671.1 - 2.1e-11 44.2 0.0 3e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 PCI domain eIF3m_C_helix PF18005.1 EFE42671.1 - 8.1e-11 41.4 3.6 1.6e-10 40.5 3.6 1.5 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix Rrf2 PF02082.20 EFE42671.1 - 0.13 12.7 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator K_channel_TID PF07941.11 EFE42671.1 - 0.15 12.5 10.0 0.18 12.3 8.5 1.8 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain ADK PF00406.22 EFE42672.1 - 9.9e-38 129.6 0.1 2.6e-37 128.2 0.1 1.7 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFE42672.1 - 3e-31 108.7 0.1 5.6e-31 107.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFE42672.1 - 0.00011 22.7 0.0 0.00019 22.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain MFS_1 PF07690.16 EFE42673.1 - 4.3e-29 101.5 30.7 6.1e-29 101.0 30.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MARVEL PF01284.23 EFE42674.1 - 0.019 15.0 1.7 0.021 14.9 0.2 1.9 2 0 0 2 2 2 0 Membrane-associating domain ECF_trnsprt PF12822.7 EFE42674.1 - 0.28 11.3 2.3 0.65 10.1 2.5 1.4 1 1 0 1 1 1 0 ECF transporter, substrate-specific component Cnd2 PF05786.14 EFE42675.1 - 0 1021.1 3.5 0 1020.9 3.5 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EFE42675.1 - 0.0043 17.3 0.0 0.016 15.4 0.0 2.0 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Ribosomal_60s PF00428.19 EFE42675.1 - 4.7 7.9 9.1 6.1 7.5 0.1 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein Na_Ca_ex PF01699.24 EFE42676.1 - 9.4e-50 168.5 41.9 8.5e-27 94.0 16.7 2.7 2 0 0 2 2 2 2 Sodium/calcium exchanger protein EF-hand_4 PF12763.7 EFE42677.1 - 1.6e-15 56.9 0.0 1.6e-12 47.3 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand WH2 PF02205.20 EFE42677.1 - 2.1e-10 40.1 0.2 6.2e-10 38.6 0.2 1.9 1 0 0 1 1 1 1 WH2 motif DUF1720 PF08226.11 EFE42677.1 - 5.4e-06 26.7 60.0 2e-05 24.9 33.2 6.9 4 3 2 6 6 6 2 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 EFE42677.1 - 0.0048 16.4 0.0 0.15 11.7 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EFE42677.1 - 0.0084 16.5 2.8 0.14 12.7 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 EFE42677.1 - 0.11 12.4 0.0 4.2 7.3 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair RNA_pol_L_2 PF13656.6 EFE42678.1 - 3.6e-14 52.3 0.1 3.1e-11 42.9 0.1 2.3 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFE42678.1 - 3e-06 26.6 0.0 0.077 12.4 0.0 2.3 2 0 0 2 2 2 2 RNA polymerase Rpb3/Rpb11 dimerisation domain NMO PF03060.15 EFE42680.1 - 2.5e-33 115.9 4.4 1.1e-27 97.4 1.8 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 EFE42680.1 - 3.3e-08 32.9 3.5 5.6e-08 32.2 3.5 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EFE42680.1 - 0.0026 16.9 3.7 0.0038 16.4 3.7 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EFE42680.1 - 0.0064 15.5 9.8 0.014 14.4 6.2 2.6 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain LRR_4 PF12799.7 EFE42682.1 - 7e-08 32.7 3.1 1.9 9.1 0.0 6.6 6 2 2 8 8 8 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFE42682.1 - 6.8e-06 25.7 4.9 1.7 8.9 0.0 6.3 7 0 0 7 7 7 3 Leucine Rich repeat LRR_8 PF13855.6 EFE42682.1 - 0.018 14.8 2.8 13 5.6 0.0 5.2 6 0 0 6 6 6 0 Leucine rich repeat LRR_1 PF00560.33 EFE42682.1 - 2.3 9.1 8.2 1.1e+02 4.0 0.0 5.9 6 1 0 6 6 6 0 Leucine Rich Repeat MFS_1 PF07690.16 EFE42685.1 - 1.5e-33 116.2 51.9 7.2e-24 84.4 18.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE42685.1 - 1.5e-07 30.7 16.7 1.5e-07 30.7 16.7 3.0 2 1 0 2 2 2 1 Sugar (and other) transporter p450 PF00067.22 EFE42686.1 - 5.5e-07 28.7 0.0 6.5e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HNH_2 PF13391.6 EFE42687.1 - 2.8e-08 33.8 0.2 8.5e-08 32.2 0.1 2.0 2 0 0 2 2 2 1 HNH endonuclease APH PF01636.23 EFE42688.1 - 1.1e-08 35.3 0.0 6.7e-08 32.7 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFE42688.1 - 0.00035 20.0 0.0 0.00054 19.4 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EFE42688.1 - 0.0021 17.7 0.0 0.0057 16.3 0.0 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EFE42688.1 - 0.012 14.5 0.0 0.02 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Kdo PF06293.14 EFE42688.1 - 0.089 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EFE42689.1 - 1.3e-14 54.2 0.0 2.3e-14 53.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42689.1 - 3.1e-10 39.8 0.0 1.5e-09 37.5 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.9 EFE42689.1 - 0.064 12.8 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pyr_redox_2 PF07992.14 EFE42690.1 - 3.6e-33 115.1 0.0 4.9e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE42690.1 - 2.4e-12 47.3 0.0 6.6e-09 36.2 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE42690.1 - 3.7e-08 33.0 0.0 3e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE42690.1 - 2.8e-06 26.7 0.1 1.1e-05 24.8 0.1 1.8 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EFE42690.1 - 0.0085 15.2 0.0 3 6.8 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Eno-Rase_NADH_b PF12242.8 EFE42690.1 - 0.013 15.3 0.2 0.74 9.6 0.0 3.0 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DAO PF01266.24 EFE42690.1 - 0.022 14.3 0.0 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EFE42690.1 - 0.032 13.1 0.0 1.7 7.4 0.0 2.8 2 1 0 3 3 3 0 Tryptophan halogenase TrkA_N PF02254.18 EFE42690.1 - 0.096 13.0 0.0 8.8 6.6 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_8 PF13450.6 EFE42690.1 - 0.13 12.6 0.0 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Fungal_trans PF04082.18 EFE42691.1 - 3.8e-15 55.6 1.6 5.1e-15 55.2 1.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EFE42692.1 - 8.3e-29 100.6 64.6 5.5e-19 68.3 33.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily His_Phos_1 PF00300.22 EFE42694.1 - 0.00024 20.9 1.3 1.8 8.2 0.0 4.0 4 0 0 4 4 4 3 Histidine phosphatase superfamily (branch 1) Peptidase_M35 PF02102.15 EFE42695.1 - 9.8e-106 353.6 9.7 1.3e-105 353.3 9.7 1.1 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EFE42695.1 - 1.1e-45 155.8 3.7 2.5e-45 154.6 3.7 1.6 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 EFE42695.1 - 2e-05 24.3 4.8 0.00018 21.2 4.8 2.0 1 1 0 1 1 1 1 Putative peptidase family UPF0160 PF03690.13 EFE42696.1 - 3.5e-120 401.4 0.0 4e-120 401.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Trimer_CC PF08954.11 EFE42696.1 - 0.0085 15.6 0.0 0.37 10.4 0.0 2.4 2 0 0 2 2 2 1 Trimerisation motif 5_nucleotid_C PF02872.18 EFE42697.1 - 3.7e-37 128.0 0.0 5.9e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EFE42697.1 - 1.5e-06 28.9 0.0 2.7e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Kinesin PF00225.23 EFE42698.1 - 1.4e-112 376.0 0.4 4.5e-112 374.3 0.4 2.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFE42698.1 - 1.8e-26 92.9 0.1 7.8e-26 90.8 0.1 2.1 1 0 0 1 1 1 1 Microtubule binding DUF1398 PF07166.11 EFE42698.1 - 0.07 13.2 1.4 0.14 12.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1398) HALZ PF02183.18 EFE42698.1 - 0.095 12.9 11.2 2.6 8.4 0.8 4.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper LEA_6 PF10714.9 EFE42698.1 - 0.18 11.9 1.5 0.48 10.5 1.5 1.7 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 HAP1_N PF04849.13 EFE42698.1 - 7.1 5.7 50.9 0.094 11.9 19.5 3.7 2 1 0 3 3 3 0 HAP1 N-terminal conserved region Thiolase_N PF00108.23 EFE42699.1 - 2.2e-92 309.1 1.4 2.9e-92 308.7 1.4 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFE42699.1 - 3.3e-37 126.9 0.7 3.3e-37 126.9 0.7 1.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFE42699.1 - 9.6e-05 22.1 0.4 0.00022 20.9 0.4 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EFE42699.1 - 0.0033 17.2 1.5 2.5 8.0 0.0 3.3 3 0 0 3 3 3 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Asp_protease_2 PF13650.6 EFE42700.1 - 0.029 15.0 0.2 0.039 14.6 0.2 1.3 1 0 0 1 1 1 0 Aspartyl protease UQ_con PF00179.26 EFE42702.1 - 2.3e-44 150.4 0.0 1.1e-43 148.3 0.0 1.8 1 1 1 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFE42702.1 - 0.00083 19.1 0.0 0.00098 18.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFE42702.1 - 0.1 12.9 0.0 0.15 12.4 0.0 1.4 1 1 0 1 1 1 0 RWD domain Cation_efflux PF01545.21 EFE42703.1 - 1.5e-42 145.6 13.5 1.5e-42 145.6 13.5 2.5 2 0 0 2 2 2 1 Cation efflux family AveC_like PF17198.4 EFE42703.1 - 0.0033 16.9 0.1 0.011 15.2 0.1 1.9 1 0 0 1 1 1 1 Spirocyclase AveC-like Glyco_trans_4_4 PF13579.6 EFE42704.1 - 1e-07 32.5 0.5 1.7e-07 31.8 0.5 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 EFE42704.1 - 9.3e-06 26.1 0.0 2.5e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFE42704.1 - 1.9e-05 24.8 0.8 2.7e-05 24.2 0.8 1.2 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EFE42704.1 - 0.0066 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EFE42704.1 - 0.025 14.9 0.0 0.063 13.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 TFIIIC_delta PF12657.7 EFE42705.1 - 1.4e-43 149.0 0.2 3e-43 147.9 0.2 1.6 1 0 0 1 1 1 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 EFE42705.1 - 2.8e-30 104.3 1.7 5.4e-30 103.3 1.7 1.5 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex Mito_carr PF00153.27 EFE42706.1 - 4.5e-52 173.9 5.3 6.9e-19 67.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LtrA PF06772.11 EFE42707.1 - 1.4e-19 70.6 26.1 1.4e-19 70.6 26.1 2.1 2 0 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) DUF2976 PF11190.8 EFE42707.1 - 0.038 13.8 0.2 0.038 13.8 0.2 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2976) DUF3188 PF11384.8 EFE42707.1 - 0.11 12.2 0.9 0.46 10.2 0.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) AA_permease PF00324.21 EFE42709.1 - 5.4e-28 97.8 5.7 4.3e-27 94.9 5.7 1.8 1 1 0 1 1 1 1 Amino acid permease 7tm_1 PF00001.21 EFE42709.1 - 0.0075 15.6 0.2 0.12 11.7 0.0 2.2 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Gate PF07670.14 EFE42709.1 - 0.067 13.5 0.3 0.85 9.9 0.2 2.3 2 0 0 2 2 2 0 Nucleoside recognition PP_M1 PF03012.14 EFE42709.1 - 0.22 11.0 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 Phosphoprotein CFEM PF05730.11 EFE42711.1 - 7.5e-13 48.4 4.0 1.1e-12 47.9 4.0 1.2 1 0 0 1 1 1 1 CFEM domain FNIP_N PF14636.6 EFE42713.1 - 1.8e-33 116.7 0.3 1.8e-33 116.7 0.3 4.3 3 2 0 4 4 4 1 Folliculin-interacting protein N-terminus FNIP_M PF14637.6 EFE42713.1 - 0.047 13.7 0.2 0.15 12.0 0.1 1.8 1 1 1 2 2 2 0 Folliculin-interacting protein middle domain IML1 PF12257.8 EFE42714.1 - 8.4e-108 359.8 0.0 1.2e-107 359.3 0.0 1.2 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EFE42714.1 - 3.8e-29 100.6 1.0 7.6e-29 99.6 1.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Rad60-SLD_2 PF13881.6 EFE42716.1 - 2.1e-12 47.1 0.0 4.4e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFE42716.1 - 0.0063 17.1 0.1 0.017 15.7 0.0 1.7 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EFE42716.1 - 0.0085 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UMP1 PF05348.11 EFE42717.1 - 6.5e-39 132.8 0.1 8.2e-39 132.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Ribosom_S12_S23 PF00164.25 EFE42718.1 - 8.7e-16 57.6 0.6 1.7e-15 56.6 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Glyco_transf_15 PF01793.16 EFE42719.1 - 4.2e-122 407.5 11.2 5.8e-122 407.0 11.2 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF4106 PF13388.6 EFE42719.1 - 0.083 12.1 4.3 0.11 11.7 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Fungal_trans PF04082.18 EFE42720.1 - 2.3e-19 69.4 3.3 4.2e-19 68.6 3.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EFE42720.1 - 3.4e-07 30.4 13.4 7.6e-05 23.0 5.5 2.9 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE42720.1 - 0.012 16.4 14.8 0.81 10.7 1.3 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE42720.1 - 0.014 15.8 18.3 0.26 11.8 7.6 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type Mucin PF01456.17 EFE42720.1 - 0.025 14.6 13.9 0.06 13.3 13.9 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein zf-C2H2_3rep PF18868.1 EFE42720.1 - 0.095 13.4 2.5 2 9.1 0.0 3.0 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-CHY PF05495.12 EFE42720.1 - 1 9.9 6.5 0.81 10.2 3.5 2.2 2 0 0 2 2 2 0 CHY zinc finger Tho2 PF11262.8 EFE42721.1 - 0.072 12.3 7.8 0.086 12.0 7.8 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 TMEM119 PF15724.5 EFE42721.1 - 2.9 7.9 7.7 3.1 7.8 7.7 1.1 1 0 0 1 1 1 0 TMEM119 family NPR3 PF03666.13 EFE42721.1 - 3.5 6.3 11.3 3.8 6.2 11.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4407 PF14362.6 EFE42721.1 - 6.6 6.0 6.8 7.5 5.8 6.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPRTase PF14681.6 EFE42722.1 - 1.6e-63 213.9 0.0 4.3e-63 212.5 0.0 1.6 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EFE42722.1 - 3.3e-06 26.7 0.0 5.2e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain CRCB PF02537.15 EFE42723.1 - 3.9e-41 139.3 10.6 2.4e-24 85.5 4.4 2.4 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) JAB PF01398.21 EFE42724.1 - 2.5e-29 101.7 0.0 4e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EFE42724.1 - 1.8e-24 86.5 0.0 3.4e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EFE42724.1 - 0.0013 18.5 0.0 0.0029 17.4 0.0 1.6 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain SRP1_TIP1 PF00660.17 EFE42724.1 - 0.12 12.5 0.1 0.26 11.4 0.1 1.6 1 0 0 1 1 1 0 Seripauperin and TIP1 family Pkinase PF00069.25 EFE42725.1 - 3.7e-23 82.2 0.0 4.7e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42725.1 - 4.8e-18 65.4 0.0 9.2e-18 64.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFE42725.1 - 0.00016 21.1 0.1 0.00025 20.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFE42725.1 - 0.014 15.0 0.0 0.039 13.5 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase MAP65_ASE1 PF03999.12 EFE42726.1 - 1.9e-70 238.2 19.5 8.1e-70 236.2 19.6 1.8 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Occludin_ELL PF07303.13 EFE42726.1 - 0.13 13.0 1.7 4 8.2 0.1 3.3 2 1 0 2 2 2 0 Occludin homology domain DUF5101 PF17031.5 EFE42726.1 - 0.31 11.2 2.1 0.31 11.2 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) Seryl_tRNA_N PF02403.22 EFE42726.1 - 0.49 10.7 12.0 14 5.9 0.0 4.2 5 0 0 5 5 5 0 Seryl-tRNA synthetase N-terminal domain Spectrin PF00435.21 EFE42726.1 - 0.65 10.5 5.3 0.51 10.9 0.7 3.0 3 0 0 3 3 3 0 Spectrin repeat CC2-LZ PF16516.5 EFE42726.1 - 2.1 8.7 6.9 0.98 9.8 0.1 3.3 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator tRNA-synt_1c PF00749.21 EFE42728.1 - 1.2e-41 142.7 0.0 4.7e-41 140.7 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain DnaJ_C PF01556.18 EFE42729.1 - 4e-39 134.1 0.4 6.9e-39 133.3 0.4 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EFE42729.1 - 4.3e-13 49.4 19.0 7.8e-13 48.6 19.0 1.4 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.31 EFE42729.1 - 5.2e-13 48.9 2.3 9.5e-13 48.1 2.3 1.4 1 0 0 1 1 1 1 DnaJ domain zf-RING_10 PF16685.5 EFE42729.1 - 1.8 8.7 6.0 17 5.6 0.6 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 TackOD1 PF18551.1 EFE42729.1 - 5.9 6.5 7.5 1.4 8.6 1.0 2.2 1 1 0 2 2 2 0 Thaumarchaeal output domain 1 DUF1356 PF07092.12 EFE42729.1 - 7.1 5.8 5.0 25 4.0 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) 4HBT PF03061.22 EFE42730.1 - 5.1e-10 39.6 0.0 6.9e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 EFE42730.1 - 0.0059 17.1 0.0 0.007 16.9 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily PseudoU_synth_2 PF00849.22 EFE42731.1 - 3.7e-25 88.9 0.0 5.9e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 EFE42731.1 - 0.073 12.8 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 S4 domain Glyco_tran_WecB PF03808.13 EFE42731.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family Ribosomal_L32e PF01655.18 EFE42732.1 - 8.5e-38 129.1 0.9 4.8e-30 104.1 0.0 2.0 2 0 0 2 2 2 2 Ribosomal protein L32 Sec2p PF06428.11 EFE42733.1 - 3.2e-10 39.9 13.2 3.2e-10 39.9 13.2 2.0 2 1 0 2 2 2 1 GDP/GTP exchange factor Sec2p ATG16 PF08614.11 EFE42733.1 - 0.0064 16.8 13.3 0.0064 16.8 13.3 2.9 1 1 0 2 2 2 1 Autophagy protein 16 (ATG16) Lebercilin PF15619.6 EFE42733.1 - 0.039 13.6 15.4 0.018 14.7 9.2 2.3 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4795 PF16043.5 EFE42733.1 - 0.082 12.5 4.9 0.11 12.0 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) DUF2072 PF09845.9 EFE42733.1 - 0.088 13.1 3.4 2 8.7 0.0 2.4 2 0 0 2 2 2 0 Zn-ribbon containing protein DUF4407 PF14362.6 EFE42733.1 - 0.76 9.1 12.1 5.7e+02 -0.4 12.1 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 EFE42733.1 - 1.7 7.4 12.0 0.13 11.1 6.2 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein RRM_1 PF00076.22 EFE42734.1 - 2.8e-14 52.7 0.0 5.7e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pns11_12 PF17464.2 EFE42734.1 - 0.046 13.4 8.6 0.082 12.6 8.6 1.5 1 0 0 1 1 1 0 Non-structural protein 11 and 12 2-Hacid_dh_C PF02826.19 EFE42735.1 - 1e-54 184.6 0.0 1.4e-54 184.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFE42735.1 - 2.1e-16 59.8 0.0 2.4e-16 59.6 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFE42735.1 - 1e-06 29.0 0.0 1.5e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase GFO_IDH_MocA PF01408.22 EFE42735.1 - 0.0021 18.9 0.0 0.0097 16.7 0.0 2.1 2 1 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold zf-C2HE PF16278.5 EFE42736.1 - 5.1e-20 71.7 1.1 5.1e-20 71.7 1.1 1.8 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 EFE42736.1 - 1.3e-05 25.7 0.0 2.3e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 EFE42736.1 - 6.6e-05 23.6 0.0 0.00012 22.8 0.0 1.4 1 0 0 1 1 1 1 HIT domain Cyclin_N PF00134.23 EFE42737.1 - 8.4e-45 151.6 0.4 1.6e-44 150.7 0.4 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFE42737.1 - 1.2e-34 118.9 0.3 7.1e-34 116.5 0.0 2.5 3 0 0 3 3 3 1 Cyclin, C-terminal domain TFIIA PF03153.13 EFE42737.1 - 1.1 9.1 21.9 1.6 8.7 21.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zn_clus PF00172.18 EFE42739.1 - 0.00079 19.5 12.6 0.0016 18.5 12.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.10 EFE42739.1 - 0.033 13.7 0.4 0.36 10.4 0.0 2.6 2 0 0 2 2 2 0 Histone chaperone domain CHZ DUF4349 PF14257.6 EFE42739.1 - 0.077 12.4 0.0 0.077 12.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) RNA_pol_Rpc4 PF05132.14 EFE42740.1 - 3.7e-33 115.1 0.1 3.7e-33 115.1 0.1 3.4 1 1 1 2 2 2 1 RNA polymerase III RPC4 KRE1 PF17056.5 EFE42741.1 - 3.4e-07 29.9 0.0 5.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Killer toxin-resistance protein 1 Apt1 PF10351.9 EFE42742.1 - 8.8e-182 605.2 0.1 8.8e-182 605.2 0.1 2.3 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27 PF10344.9 EFE42742.1 - 1.5e-171 572.6 0.0 2.9e-171 571.7 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.9 EFE42742.1 - 8e-169 562.5 1.5 1.2e-168 562.0 1.5 1.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 EFE42742.1 - 2.7e-55 186.8 0.1 7.5e-55 185.3 0.0 1.8 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EFE42742.1 - 1e-51 174.9 0.0 2.4e-51 173.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 EFE42742.1 - 8.2e-28 97.1 0.0 4.3e-27 94.8 0.0 2.4 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain B-block_TFIIIC PF04182.12 EFE42744.1 - 2.8e-21 75.5 0.1 6.1e-21 74.4 0.1 1.6 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC MarR_2 PF12802.7 EFE42744.1 - 0.08 12.8 0.1 0.08 12.8 0.1 3.4 4 0 0 4 4 4 0 MarR family HTH_36 PF13730.6 EFE42744.1 - 0.13 12.2 0.0 0.39 10.7 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain MarR PF01047.22 EFE42744.1 - 0.18 11.8 0.9 1.4 8.9 0.0 2.9 3 0 0 3 3 3 0 MarR family UQ_con PF00179.26 EFE42745.1 - 7.1e-17 61.4 0.0 1.1e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DHHC PF01529.20 EFE42746.1 - 1.3e-36 125.7 12.1 1.3e-36 125.7 12.1 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase TFIIE-A_C PF11521.8 EFE42748.1 - 0.032 14.5 7.3 0.034 14.4 7.3 1.1 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha EP400_N PF15790.5 EFE42748.1 - 10 4.9 5.5 9 5.0 5.5 1.0 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal Rhomboid PF01694.22 EFE42749.1 - 3.7e-33 114.7 7.9 3.7e-33 114.7 7.9 2.4 3 0 0 3 3 3 1 Rhomboid family DUF2177 PF09945.9 EFE42749.1 - 0.28 11.3 6.0 0.45 10.6 0.4 2.9 2 1 1 3 3 3 0 Predicted membrane protein (DUF2177) GST_C_2 PF13410.6 EFE42750.1 - 4.1e-05 23.5 0.0 8.2e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFE42750.1 - 0.1 12.8 0.0 0.34 11.1 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Kinetochor_Ybp2 PF08568.10 EFE42751.1 - 2.4e-116 389.7 0.1 2.9e-116 389.5 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin PLDc_2 PF13091.6 EFE42752.1 - 2.2e-15 56.7 0.1 2.6e-07 30.6 0.0 3.7 3 1 0 3 3 3 2 PLD-like domain PLDc PF00614.22 EFE42752.1 - 7.3e-14 51.3 0.6 1.9e-06 27.8 0.0 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif SUIM_assoc PF16619.5 EFE42752.1 - 0.0053 16.8 4.1 0.0053 16.8 4.1 3.7 2 1 1 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 EFE42752.1 - 0.04 12.9 14.9 0.067 12.1 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF4834 PF16118.5 EFE42752.1 - 0.048 14.6 6.4 0.63 11.0 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF883 PF05957.13 EFE42752.1 - 7.7 7.2 5.8 1.6 9.4 0.9 2.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Cyanate_lyase PF02560.14 EFE42753.1 - 1.4e-29 101.7 0.0 3.1e-29 100.6 0.0 1.5 2 0 0 2 2 2 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 EFE42753.1 - 0.00015 22.0 0.0 0.00024 21.4 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 EFE42753.1 - 0.001 19.4 0.0 0.0017 18.7 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_3 PF01381.22 EFE42753.1 - 0.024 14.7 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix Sigma70_r1_1 PF03979.14 EFE42753.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 zf-C2H2_4 PF13894.6 EFE42754.1 - 6.8e-09 35.8 15.9 0.46 11.5 0.1 6.4 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE42754.1 - 0.00047 20.5 20.5 0.11 13.0 0.0 5.2 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 EFE42754.1 - 0.00086 20.0 4.5 0.019 15.6 0.7 2.9 3 0 0 3 3 3 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 EFE42754.1 - 0.051 13.9 0.0 0.051 13.9 0.0 4.4 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFE42754.1 - 0.21 12.0 0.0 0.21 12.0 0.0 4.2 5 0 0 5 5 4 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFE42754.1 - 0.22 11.9 14.2 3.4 8.1 0.0 4.2 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 EFE42754.1 - 0.31 11.2 4.5 0.61 10.2 1.0 2.6 1 1 1 2 2 2 0 Zinc ribbon domain zf-CSL PF05207.13 EFE42754.1 - 0.45 10.3 4.1 15 5.4 0.0 2.6 2 1 0 2 2 2 0 CSL zinc finger zinc_ribbon_4 PF13717.6 EFE42754.1 - 1.8 8.5 5.4 22 5.1 1.4 3.0 2 1 0 2 2 2 0 zinc-ribbon domain Cytochrom_CIII PF02085.16 EFE42754.1 - 6.1 7.2 8.8 17 5.8 8.8 1.8 1 0 0 1 1 1 0 Class III cytochrome C family FOXP-CC PF16159.5 EFE42754.1 - 9.1 7.0 7.6 2.6 8.7 0.3 3.2 3 1 0 3 3 3 0 FOXP coiled-coil domain DUF349 PF03993.12 EFE42756.1 - 0.033 14.5 1.7 0.055 13.8 1.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) MFS_1 PF07690.16 EFE42757.1 - 1.3e-05 24.3 4.4 0.00093 18.2 0.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily HRG PF16954.5 EFE42757.1 - 3.9 7.9 8.0 0.52 10.7 1.6 2.5 3 0 0 3 3 3 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene MFS_1 PF07690.16 EFE42758.1 - 4.9e-26 91.5 38.5 9.4e-26 90.6 38.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily LacY_symp PF01306.19 EFE42758.1 - 9.9e-05 21.3 0.9 9.9e-05 21.3 0.9 1.7 2 0 0 2 2 2 1 LacY proton/sugar symporter FAD_binding_3 PF01494.19 EFE42759.1 - 1.6e-15 57.2 0.0 3.6e-11 42.9 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EFE42759.1 - 1.3e-05 25.0 0.0 0.00017 21.3 0.0 2.5 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE42759.1 - 0.00027 21.1 0.0 0.00065 19.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE42759.1 - 0.00055 19.2 0.0 0.001 18.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFE42759.1 - 0.00077 18.9 0.1 0.0052 16.2 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EFE42759.1 - 0.0011 18.2 0.0 0.0025 17.0 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EFE42759.1 - 0.0022 16.8 0.0 0.0046 15.7 0.0 1.5 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EFE42759.1 - 0.0071 16.9 0.0 0.014 16.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EFE42759.1 - 0.045 13.6 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EFE42759.1 - 0.064 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SE PF08491.10 EFE42759.1 - 0.11 11.5 0.0 0.4 9.7 0.0 1.8 1 1 0 1 1 1 0 Squalene epoxidase DNA_pol_B PF00136.21 EFE42760.1 - 1.5e-146 488.7 2.9 2e-146 488.3 2.9 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFE42760.1 - 1.4e-79 267.7 0.2 2.5e-79 266.9 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EFE42760.1 - 2e-19 69.8 3.1 4.7e-19 68.6 3.1 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.6 EFE42760.1 - 0.00051 20.1 0.2 0.0025 17.8 0.2 2.2 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.9 EFE42760.1 - 0.009 15.7 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DNA_pol_B_2 PF03175.13 EFE42760.1 - 0.014 14.3 0.6 0.022 13.6 0.0 1.7 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral C1_1 PF00130.22 EFE42760.1 - 0.018 14.9 6.7 0.074 13.0 1.0 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ETC_C1_NDUFA5 PF04716.14 EFE42760.1 - 0.064 13.1 0.0 0.17 11.7 0.0 1.8 1 0 0 1 1 1 0 ETC complex I subunit conserved region Fungal_trans_2 PF11951.8 EFE42761.1 - 1.6e-10 40.4 0.7 1.4e-09 37.2 0.2 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Pkinase PF00069.25 EFE42762.1 - 7.7e-32 110.7 0.0 3.7e-17 62.5 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42762.1 - 1e-12 47.9 0.0 9e-06 25.2 0.0 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase DUF2153 PF09921.9 EFE42762.1 - 0.082 12.7 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) Glyco_hydro_47 PF01532.20 EFE42763.1 - 6.5e-181 602.2 0.0 7.5e-181 602.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 TAtT PF16811.5 EFE42763.1 - 0.14 11.4 0.1 0.6 9.3 0.0 1.9 2 0 0 2 2 2 0 TRAP transporter T-component EF-1_beta_acid PF10587.9 EFE42763.1 - 0.3 11.6 2.8 0.76 10.3 2.8 1.7 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region LIP PF03583.14 EFE42764.1 - 1.1e-78 264.5 0.0 1.5e-78 264.1 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase DUF5011 PF16403.5 EFE42764.1 - 0.12 12.6 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5011) Syja_N PF02383.18 EFE42765.1 - 2e-77 260.6 0.0 3.4e-77 259.9 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Tti2 PF10521.9 EFE42766.1 - 5.9e-89 298.3 1.6 7.7e-89 298.0 1.6 1.1 1 0 0 1 1 1 1 Tti2 family PolyA_pol PF01743.20 EFE42767.1 - 5.2e-24 85.1 0.1 1.9e-23 83.3 0.1 2.0 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EFE42767.1 - 1.9e-06 27.5 0.0 4.4e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EFE42767.1 - 0.00015 21.8 0.0 0.00026 21.0 0.0 1.3 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative TRAPPC-Trs85 PF12739.7 EFE42768.1 - 3.2e-105 352.4 0.1 3.1e-83 280.0 0.0 3.0 2 1 1 3 3 3 3 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DNase_NucA_NucB PF14040.6 EFE42769.1 - 0.15 12.4 0.0 0.26 11.6 0.0 1.3 1 0 0 1 1 1 0 Deoxyribonuclease NucA/NucB Snf7 PF03357.21 EFE42770.1 - 5.9e-18 65.1 10.7 5.9e-18 65.1 10.7 2.1 1 1 1 2 2 2 1 Snf7 DUF948 PF06103.11 EFE42770.1 - 0.019 15.2 10.7 0.52 10.6 2.3 3.6 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF16 PF01519.16 EFE42770.1 - 0.031 14.8 1.0 0.031 14.8 1.0 3.2 1 1 1 2 2 1 0 Protein of unknown function DUF16 LPP PF04728.13 EFE42770.1 - 0.54 10.7 0.1 0.54 10.7 0.1 3.4 5 1 0 5 5 5 0 Lipoprotein leucine-zipper MCU PF04678.13 EFE42770.1 - 0.7 10.0 6.1 0.87 9.7 0.2 2.4 1 1 1 2 2 2 0 Mitochondrial calcium uniporter BLOC1_2 PF10046.9 EFE42770.1 - 1 9.7 15.9 3.4 8.0 0.3 4.4 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin_2 PF01920.20 EFE42770.1 - 1.2 9.2 14.5 1.7 8.6 0.3 3.0 2 1 0 2 2 2 0 Prefoldin subunit COG5 PF10392.9 EFE42770.1 - 1.4 9.1 8.0 1.5 9.0 0.9 3.0 2 2 1 3 3 3 0 Golgi transport complex subunit 5 Wbp11 PF09429.10 EFE42770.1 - 2.5 8.5 17.7 1.4 9.3 3.2 4.1 3 1 1 4 4 4 0 WW domain binding protein 11 SlyX PF04102.12 EFE42770.1 - 4 8.1 13.4 0.85 10.3 0.2 4.1 2 1 3 5 5 5 0 SlyX V_ATPase_I PF01496.19 EFE42770.1 - 4.1 5.2 8.6 3.3 5.5 3.5 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Het-C PF07217.11 EFE42770.1 - 5.5 5.4 8.8 0.5 8.8 2.5 1.8 1 1 1 2 2 2 0 Heterokaryon incompatibility protein Het-C DASH_Dad3 PF08656.10 EFE42770.1 - 9.4 6.4 11.4 1.2e+04 -3.5 11.4 3.7 1 1 0 1 1 1 0 DASH complex subunit Dad3 zf-C3HC4_2 PF13923.6 EFE42771.1 - 3.1e-10 39.7 22.2 1e-09 38.0 15.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE42771.1 - 3.8e-07 29.8 13.4 3.8e-07 29.8 13.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EFE42771.1 - 9.7e-07 28.6 7.7 9.7e-07 28.6 7.7 1.7 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4 PF00097.25 EFE42771.1 - 2.4e-06 27.3 17.0 2.4e-06 27.3 17.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE42771.1 - 1.2e-05 25.2 16.4 1.2e-05 25.2 16.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFE42771.1 - 2e-05 24.9 22.1 4.1e-05 23.8 17.0 2.3 2 0 0 2 2 2 1 Ring finger domain SAP PF02037.27 EFE42771.1 - 2.9e-05 23.7 0.0 5.5e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 SAP domain zf-RING_UBOX PF13445.6 EFE42771.1 - 0.00017 21.5 22.8 0.00018 21.5 17.3 2.5 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFE42771.1 - 0.00035 20.4 17.1 0.069 13.0 15.1 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFE42771.1 - 0.00042 20.4 20.3 0.00073 19.6 17.0 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING U-box PF04564.15 EFE42771.1 - 0.019 15.1 0.3 0.069 13.3 0.0 2.1 3 0 0 3 3 2 0 U-box domain Mob_synth_C PF06463.13 EFE42771.1 - 0.032 14.2 5.3 0.069 13.1 5.3 1.5 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C zf-ANAPC11 PF12861.7 EFE42771.1 - 0.21 11.7 5.2 0.53 10.4 5.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.14 EFE42771.1 - 0.22 11.4 4.1 6.3 6.7 1.4 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-rbx1 PF12678.7 EFE42771.1 - 0.37 11.1 16.6 0.068 13.5 11.9 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-WRNIP1_ubi PF18279.1 EFE42771.1 - 1.8 9.4 5.1 3.7 8.4 0.2 2.8 3 0 0 3 3 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-RING_10 PF16685.5 EFE42771.1 - 4.2 7.6 13.5 0.33 11.1 8.1 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 CDC27 PF09507.10 EFE42772.1 - 4.4e-63 214.2 30.3 5.1e-63 213.9 30.3 1.0 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Glyco_hydro_125 PF06824.11 EFE42773.1 - 2.2e-173 577.0 0.1 1.2e-149 498.8 0.0 2.0 1 1 1 2 2 2 2 Metal-independent alpha-mannosidase (GH125) RRM_1 PF00076.22 EFE42774.1 - 0.003 17.4 0.0 1.2 9.0 0.0 2.5 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NMD3 PF04981.13 EFE42775.1 - 1.9e-79 266.6 3.9 3.3e-79 265.8 3.9 1.4 1 0 0 1 1 1 1 NMD3 family HypA PF01155.19 EFE42775.1 - 0.45 10.5 9.6 2.1 8.4 1.3 3.1 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rhodanese_C PF12368.8 EFE42775.1 - 9.4 6.7 9.5 5.2 7.5 6.3 2.0 2 0 0 2 2 2 0 Rhodanase C-terminal RsfS PF02410.15 EFE42776.1 - 3.6e-11 43.4 0.0 8e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Pex2_Pex12 PF04757.14 EFE42777.1 - 1.9e-54 184.6 2.4 2.5e-54 184.2 2.4 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EFE42777.1 - 2e-06 27.8 2.2 3.6e-06 27.0 2.2 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EFE42777.1 - 0.00031 20.5 1.8 0.00057 19.7 1.1 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE42777.1 - 0.00076 19.3 1.3 0.0014 18.4 1.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFE42777.1 - 0.0013 19.1 1.4 0.0026 18.0 1.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFE42777.1 - 0.0036 17.1 1.5 0.0069 16.2 1.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE42777.1 - 0.0044 17.0 1.7 0.0044 17.0 1.7 1.9 2 0 0 2 2 2 1 RING-type zinc-finger Mito_carr PF00153.27 EFE42778.1 - 7.8e-49 163.6 2.2 3.3e-17 62.2 0.0 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFE42778.1 - 0.0069 15.6 0.0 1.2 8.2 0.0 2.3 2 1 0 2 2 2 2 Gammaproteobacterial serine protease DUF5007 PF16398.5 EFE42778.1 - 0.2 11.3 0.0 0.32 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5007) WSD PF15613.6 EFE42779.1 - 3.5e-23 81.9 0.5 3.5e-23 81.9 0.5 3.3 4 1 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EFE42779.1 - 2.5e-17 62.9 1.5 4.4e-17 62.1 1.5 1.4 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 EFE42779.1 - 4.1e-10 38.9 0.0 1e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 CtIP_N PF10482.9 EFE42779.1 - 5.6 7.0 13.4 3.5 7.7 0.9 3.5 2 1 1 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain Mre11_DNA_bind PF04152.14 EFE42779.1 - 6.9 7.0 10.3 90 3.3 10.3 2.9 1 1 0 1 1 1 0 Mre11 DNA-binding presumed domain Alg6_Alg8 PF03155.15 EFE42780.1 - 1.9e-149 498.8 24.2 2.9e-149 498.1 24.2 1.2 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Lectin_leg-like PF03388.13 EFE42781.1 - 1.6e-17 63.6 0.0 2.7e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Legume-like lectin family Dynamitin PF04912.14 EFE42781.1 - 0.0045 16.4 1.6 0.006 16.0 1.6 1.1 1 0 0 1 1 1 1 Dynamitin TMF_TATA_bd PF12325.8 EFE42781.1 - 0.0055 16.9 1.2 0.0095 16.2 1.2 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding DUF4349 PF14257.6 EFE42781.1 - 0.0059 16.1 0.4 0.012 15.1 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) ALMT PF11744.8 EFE42781.1 - 0.041 12.7 0.5 0.058 12.2 0.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter WXG100 PF06013.12 EFE42781.1 - 0.064 13.5 0.2 0.77 10.0 0.0 2.2 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Spore_YpjB PF09577.10 EFE42781.1 - 0.071 12.9 1.4 0.36 10.6 0.2 2.1 1 1 1 2 2 2 0 Sporulation protein YpjB (SpoYpjB) FUSC PF04632.12 EFE42781.1 - 0.13 10.7 0.6 0.18 10.3 0.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family KxDL PF10241.9 EFE42781.1 - 0.19 12.1 1.3 0.38 11.0 1.3 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein Spectrin PF00435.21 EFE42781.1 - 0.21 12.1 2.9 2.2 8.8 0.2 2.3 1 1 0 2 2 2 0 Spectrin repeat DUF5385 PF17359.2 EFE42781.1 - 0.56 9.7 3.4 0.53 9.8 0.6 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5385) Fib_alpha PF08702.10 EFE42781.1 - 0.95 9.6 3.9 1.9 8.7 3.9 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EFE42781.1 - 1.1 9.3 3.3 2 8.4 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EFE42781.1 - 8.6 6.7 8.0 2.3 8.5 1.0 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) PHD PF00628.29 EFE42782.1 - 1.3e-17 63.4 16.6 2.9e-11 43.1 6.6 2.4 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 EFE42782.1 - 0.0088 15.7 7.1 0.54 9.8 2.7 2.7 2 0 0 2 2 2 2 PHD/FYVE-zinc-finger like domain Rhabdo_M2 PF04785.12 EFE42782.1 - 0.054 12.8 0.1 0.46 9.8 0.1 2.0 2 0 0 2 2 2 0 Rhabdovirus matrix protein M2 zf-HC5HC2H PF13771.6 EFE42782.1 - 0.81 10.0 4.8 2.5 8.4 1.3 2.4 2 0 0 2 2 2 0 PHD-like zinc-binding domain PHD_2 PF13831.6 EFE42782.1 - 1.5 8.4 8.9 0.87 9.2 1.2 3.2 3 0 0 3 3 3 0 PHD-finger DUF4196 PF13846.6 EFE42783.1 - 0.036 14.3 5.4 0.045 13.9 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4196) Peptidase_M24 PF00557.24 EFE42784.1 - 1.2e-05 25.1 0.2 3.1e-05 23.8 0.2 1.6 1 1 0 1 1 1 1 Metallopeptidase family M24 S-antigen PF05756.11 EFE42784.1 - 0.23 11.9 2.3 0.64 10.4 2.3 1.8 1 0 0 1 1 1 0 S-antigen protein Exo_endo_phos PF03372.23 EFE42786.1 - 1.2e-07 31.5 0.0 1.7e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MHB PF16525.5 EFE42786.1 - 0.17 12.2 0.0 16 5.8 0.0 2.4 2 0 0 2 2 2 0 Haemophore, haem-binding SNF5 PF04855.12 EFE42787.1 - 7e-64 215.9 0.0 1.5e-62 211.5 0.0 2.4 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 INO80_Ies4 PF08193.11 EFE42787.1 - 0.00058 19.9 1.5 0.00058 19.9 1.5 3.9 4 1 1 5 5 5 1 INO80 complex subunit Ies4 HEAT_2 PF13646.6 EFE42788.1 - 3.8e-08 33.6 4.4 1.8e-06 28.3 1.8 3.6 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 EFE42788.1 - 1.4e-06 28.1 6.6 0.11 12.8 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 EFE42788.1 - 4.3e-05 23.6 0.2 0.0049 16.9 0.0 4.1 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF3734 PF12536.8 EFE42788.1 - 0.015 15.6 0.4 0.37 11.2 0.1 3.3 2 0 0 2 2 2 0 Patatin phospholipase CLASP_N PF12348.8 EFE42788.1 - 0.026 14.1 0.0 4.2 6.9 0.0 3.0 1 1 1 2 2 2 0 CLASP N terminal HEAT_EZ PF13513.6 EFE42788.1 - 0.061 13.8 12.8 0.12 13.0 0.5 5.2 6 0 0 6 6 6 0 HEAT-like repeat MFS_1 PF07690.16 EFE42789.1 - 1.2e-27 96.8 30.9 1.2e-27 96.8 30.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily PHD PF00628.29 EFE42790.1 - 5.4e-09 35.8 8.0 5.4e-09 35.8 8.0 2.6 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 EFE42790.1 - 1.4e-08 34.9 1.5 1.4e-08 34.9 1.5 3.4 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EFE42790.1 - 9.2e-07 29.1 1.2 9.2e-07 29.1 1.2 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFE42790.1 - 9.3e-06 25.4 2.0 9.3e-06 25.4 2.0 3.1 3 1 1 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE42790.1 - 1.8e-05 24.5 3.5 1.8e-05 24.5 3.5 2.8 2 2 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) PHD_2 PF13831.6 EFE42790.1 - 3.9e-05 23.1 3.9 9.2e-05 21.9 3.9 1.7 1 0 0 1 1 1 1 PHD-finger zf-RING_5 PF14634.6 EFE42790.1 - 4e-05 23.5 2.2 4e-05 23.5 2.2 2.5 2 2 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFE42790.1 - 5.2e-05 23.0 1.5 5.2e-05 23.0 1.5 2.7 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EFE42790.1 - 8.1e-05 22.4 1.0 8.1e-05 22.4 1.0 3.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFE42790.1 - 0.00049 20.1 0.3 0.00049 20.1 0.3 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EFE42790.1 - 0.0032 17.4 1.9 0.0032 17.4 1.9 3.8 2 2 1 3 3 2 1 RING-type zinc-finger zinc_ribbon_16 PF17034.5 EFE42790.1 - 0.032 14.5 0.3 0.067 13.4 0.3 1.5 1 0 0 1 1 1 0 Zinc-ribbon like family DUF1644 PF07800.12 EFE42790.1 - 0.037 14.1 4.0 0.21 11.6 1.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) zf-RING_4 PF14570.6 EFE42790.1 - 1.4 8.8 6.7 0.16 11.8 1.1 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-PHD-like PF15446.6 EFE42790.1 - 3.1 7.4 10.4 0.044 13.4 2.2 2.1 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain zinc_ribbon_10 PF10058.9 EFE42790.1 - 4.7 7.0 7.5 1.4 8.7 3.9 2.0 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Zn_ribbon_17 PF17120.5 EFE42790.1 - 9.3 6.0 10.3 0.41 10.3 1.5 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Sacchrp_dh_NADP PF03435.18 EFE42791.1 - 5.4e-16 59.0 0.0 6.5e-16 58.8 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EFE42791.1 - 0.01 16.3 0.0 0.014 15.8 0.0 1.2 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EFE42791.1 - 0.11 12.5 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Abhydrolase_1 PF00561.20 EFE42793.1 - 0.00067 19.4 0.0 0.022 14.4 0.0 2.0 2 0 0 2 2 2 2 alpha/beta hydrolase fold SinI PF08671.10 EFE42793.1 - 0.13 12.1 0.8 0.34 10.7 0.1 2.1 2 0 0 2 2 2 0 Anti-repressor SinI Pinin_SDK_memA PF04696.13 EFE42794.1 - 9.5e-33 113.0 8.6 9.5e-33 113.0 8.6 2.3 3 0 0 3 3 3 1 pinin/SDK/memA/ protein conserved region DUF2098 PF09871.9 EFE42794.1 - 9.5 6.6 8.5 1.3 9.5 0.5 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) DIOX_N PF14226.6 EFE42795.1 - 7.7e-30 104.1 0.0 1.2e-29 103.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFE42795.1 - 2.9e-20 72.6 0.0 8.8e-20 71.1 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2141 PF09912.9 EFE42795.1 - 0.0021 17.9 0.0 0.0044 16.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2141) MFS_1 PF07690.16 EFE42797.1 - 1.5e-37 129.3 48.8 2.9e-37 128.4 47.4 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE42797.1 - 7e-12 44.6 10.7 1.1e-11 43.9 10.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4728 PF15860.5 EFE42797.1 - 3.4 8.4 9.6 1 10.1 0.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4728) p450 PF00067.22 EFE42798.1 - 1.1e-38 133.2 0.0 1.5e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 EFE42799.1 - 2.4e-72 243.5 0.0 4e-72 242.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain HTH_51 PF18558.1 EFE42799.1 - 2e-34 117.3 0.7 5.1e-34 116.0 0.3 1.9 2 0 0 2 2 1 1 Helix-turn-helix domain Ketoacyl-synt_C PF02801.22 EFE42799.1 - 2.5e-32 111.4 0.0 4.9e-32 110.4 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 EFE42799.1 - 5.7e-24 84.7 0.0 2.8e-23 82.4 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein Acyl_transf_1 PF00698.21 EFE42799.1 - 2.3e-23 83.2 0.0 4.5e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain SAT PF16073.5 EFE42799.1 - 2.4e-19 70.0 0.0 5.6e-13 49.2 0.0 2.6 2 0 0 2 2 2 2 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_12 PF08242.12 EFE42799.1 - 1.3e-13 51.5 0.0 3.2e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE42799.1 - 8e-11 42.5 0.0 2.3e-10 41.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE42799.1 - 3.5e-10 39.9 0.0 8.7e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EFE42799.1 - 7.3e-10 39.1 0.2 2.2e-09 37.5 0.2 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_11 PF08241.12 EFE42799.1 - 1.8e-09 38.1 0.0 5.5e-09 36.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE42799.1 - 1e-08 35.2 0.0 4.4e-08 33.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Epimerase PF01370.21 EFE42799.1 - 2.2e-07 30.6 0.0 4.3e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Thiolase_N PF00108.23 EFE42799.1 - 6.5e-07 29.0 1.0 2.3e-05 23.9 0.1 2.8 3 0 0 3 3 3 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 EFE42799.1 - 1.9e-05 24.1 0.0 0.0002 20.8 0.0 2.5 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family KAsynt_C_assoc PF16197.5 EFE42799.1 - 6.6e-05 23.3 0.0 0.00016 22.1 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Polysacc_synt_2 PF02719.15 EFE42799.1 - 0.0028 16.8 0.0 0.018 14.2 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Methyltransf_32 PF13679.6 EFE42799.1 - 0.027 14.5 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain KR PF08659.10 EFE42799.1 - 0.03 14.2 0.0 0.079 12.9 0.0 1.7 1 0 0 1 1 1 0 KR domain DXP_reductoisom PF02670.16 EFE42799.1 - 0.031 15.0 0.1 0.091 13.5 0.1 1.8 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase NodS PF05401.11 EFE42799.1 - 0.041 13.5 0.0 0.085 12.5 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) Pkinase PF00069.25 EFE42800.1 - 3.7e-08 33.0 0.0 0.00026 20.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain DEAD_2 PF06733.15 EFE42800.1 - 0.12 12.0 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 DEAD_2 Cofilin_ADF PF00241.20 EFE42801.1 - 4.5e-30 103.9 0.0 1.5e-16 60.2 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Mito_carr PF00153.27 EFE42802.1 - 1.7e-66 220.2 1.2 2.3e-22 78.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CAF1 PF04857.20 EFE42803.1 - 1.6e-35 122.8 0.0 2e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease HDA2-3 PF11496.8 EFE42803.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 CAF1 PF04857.20 EFE42804.1 - 3.1e-23 82.5 0.0 3.2e-23 82.4 0.0 1.0 1 0 0 1 1 1 1 CAF1 family ribonuclease TFIIF_alpha PF05793.12 EFE42805.1 - 0.0012 17.6 14.9 0.0017 17.0 14.9 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SRP-alpha_N PF04086.13 EFE42805.1 - 0.052 13.5 19.5 0.1 12.5 19.5 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Suf PF05843.14 EFE42805.1 - 0.21 11.6 7.4 0.48 10.4 7.4 1.6 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FAM220 PF15487.6 EFE42805.1 - 0.56 9.8 11.0 1.2 8.7 11.0 1.5 1 0 0 1 1 1 0 FAM220 family TRAP_alpha PF03896.16 EFE42805.1 - 1.3 8.2 8.3 20 4.3 0.0 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 EFE42805.1 - 2.5 6.3 18.4 4.3 5.5 18.4 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4407 PF14362.6 EFE42805.1 - 4.4 6.6 8.4 7 5.9 8.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Borrelia_P83 PF05262.11 EFE42805.1 - 6.3 5.2 17.0 9.2 4.6 17.0 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF1517 PF07466.11 EFE42805.1 - 7.6 6.6 13.7 1.9e+02 2.1 13.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1517) Presenilin PF01080.17 EFE42805.1 - 9.4 4.9 14.3 17 4.0 14.3 1.4 1 0 0 1 1 1 0 Presenilin MFS_1 PF07690.16 EFE42807.1 - 5.1e-39 134.2 26.0 5.1e-39 134.2 26.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFE42807.1 - 4e-05 22.2 2.3 6.6e-05 21.5 2.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4271 PF14093.6 EFE42807.1 - 0.014 15.3 0.1 0.014 15.3 0.1 4.2 4 1 0 4 4 4 0 Domain of unknown function (DUF4271) LMP PF04778.12 EFE42808.1 - 0.0028 17.6 0.9 0.0028 17.6 0.9 2.1 2 0 0 2 2 2 1 LMP repeated region Myosin_head PF00063.21 EFE42809.1 - 4.1e-265 881.2 0.0 4.1e-265 881.2 0.0 1.7 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.19 EFE42809.1 - 3.6e-11 42.7 0.0 8.8e-11 41.5 0.0 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_tail_1 PF01576.19 EFE42809.1 - 5.8e-05 21.1 141.7 0.0017 16.3 56.2 3.3 1 1 0 2 2 2 1 Myosin tail ADIP PF11559.8 EFE42809.1 - 0.0017 18.5 11.7 0.0017 18.5 11.7 9.6 1 1 10 11 11 11 2 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 EFE42809.1 - 0.0079 16.2 6.4 0.0079 16.2 6.4 8.6 1 1 7 10 10 10 3 Protein of unknown function (DUF1664) DUF1292 PF06949.11 EFE42809.1 - 0.017 16.1 0.3 0.079 13.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1292) AAA_16 PF13191.6 EFE42809.1 - 0.062 13.7 0.0 0.062 13.7 0.0 4.6 3 2 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 EFE42809.1 - 0.31 11.3 0.0 0.31 11.3 0.0 3.6 4 1 0 4 4 4 0 AAA domain AAA_24 PF13479.6 EFE42809.1 - 0.52 10.0 6.3 9.5 5.9 0.0 3.7 3 0 0 3 3 3 0 AAA domain HemolysinCabind PF00353.19 EFE42809.1 - 0.89 9.6 2.2 15 5.7 0.1 2.3 2 0 0 2 2 2 0 RTX calcium-binding nonapeptide repeat (4 copies) Myosin_tail_1 PF01576.19 EFE42810.1 - 1.8e-13 49.3 110.4 9.9e-09 33.6 39.7 4.1 1 1 3 4 4 4 4 Myosin tail CENP-F_leu_zip PF10473.9 EFE42810.1 - 0.019 15.0 2.5 0.019 15.0 2.5 7.9 1 1 5 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 EFE42810.1 - 0.027 14.1 98.9 0.2 11.2 10.1 5.3 1 1 2 4 4 4 0 Intermediate filament protein HALZ PF02183.18 EFE42810.1 - 0.31 11.3 0.1 0.31 11.3 0.1 8.5 8 2 1 9 9 9 0 Homeobox associated leucine zipper Response_reg PF00072.24 EFE42811.1 - 6.2e-21 74.7 0.0 3.3e-14 53.0 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain DUF2052 PF09747.9 EFE42812.1 - 3e-20 73.2 16.2 2.8e-10 40.7 1.0 2.1 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Spermine_synth PF01564.17 EFE42813.1 - 0.00018 20.9 0.3 0.00035 20.0 0.3 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_23 PF13489.6 EFE42813.1 - 0.014 15.3 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Y_phosphatase3 PF13350.6 EFE42814.1 - 7.9e-59 199.4 0.0 9e-59 199.3 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Lysis_col PF02402.16 EFE42814.1 - 0.0049 16.5 0.2 0.011 15.4 0.2 1.5 1 0 0 1 1 1 1 Lysis protein Y_phosphatase2 PF03162.13 EFE42814.1 - 0.0064 16.1 0.0 0.0098 15.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFE42814.1 - 0.034 13.7 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFE42814.1 - 0.21 11.7 0.0 0.35 11.0 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Peptidase_C12 PF01088.21 EFE42815.1 - 3e-42 144.7 0.0 4e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Peptidase_S9 PF00326.21 EFE42816.1 - 5.1e-50 169.9 0.3 1.6e-49 168.3 0.2 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family PD40 PF07676.12 EFE42816.1 - 2.4e-09 36.9 1.3 0.0056 16.6 0.0 4.9 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Peptidase_S9_N PF02897.15 EFE42816.1 - 0.0099 14.7 0.0 0.022 13.6 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain DLIC PF05783.11 EFE42817.1 - 1e-25 90.6 4.9 2e-12 46.7 0.0 4.1 3 1 0 4 4 4 4 Dynein light intermediate chain (DLIC) RRM_1 PF00076.22 EFE42818.1 - 9.3e-20 70.2 0.1 4.6e-19 68.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFE42818.1 - 1.3e-05 25.2 0.0 4.6e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 EFE42818.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 EFE42818.1 - 0.15 11.8 1.8 1.6 8.5 0.0 3.2 2 0 0 2 2 2 0 Ribonuclease B OB domain Nbas_N PF15492.6 EFE42819.1 - 0.18 11.1 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal Septin PF00735.18 EFE42820.1 - 1.9e-100 335.8 0.6 2.4e-100 335.5 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EFE42820.1 - 0.00075 19.6 0.0 0.0021 18.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFE42820.1 - 0.032 13.8 0.3 2.1 7.9 0.1 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFE42820.1 - 0.036 14.1 2.5 0.89 9.6 0.0 3.1 2 1 1 3 3 3 0 Dynamin family EB1 PF03271.17 EFE42820.1 - 0.27 11.5 4.3 3.2 8.1 1.3 2.8 2 0 0 2 2 2 0 EB1-like C-terminal motif CNH PF00780.22 EFE42821.1 - 4.7e-81 272.4 0.0 3e-80 269.8 0.0 2.0 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 EFE42821.1 - 3.5e-39 134.0 0.0 7.6e-39 132.9 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 EFE42821.1 - 9.1e-38 130.3 0.0 1.6e-37 129.5 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 EFE42821.1 - 3.6e-13 49.4 0.0 8.4e-13 48.2 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pkinase PF00069.25 EFE42822.1 - 6.9e-60 202.6 0.0 1.3e-59 201.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42822.1 - 6.2e-31 107.6 0.0 3.1e-30 105.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE42822.1 - 0.00021 20.7 0.0 0.00035 20.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFE42822.1 - 0.008 15.2 0.0 0.0095 14.9 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain PyrBI_leader PF08052.11 EFE42822.1 - 0.01 15.8 0.1 2.9 7.9 0.0 2.4 2 0 0 2 2 2 1 PyrBI operon leader peptide DUF2773 PF10971.8 EFE42822.1 - 0.034 14.3 0.1 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2773) APH PF01636.23 EFE42822.1 - 0.041 13.8 0.0 0.13 12.1 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EFE42822.1 - 0.1 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFE42822.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 EFE42822.1 - 0.24 10.4 0.0 0.37 9.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gly_transf_sug PF04488.15 EFE42823.1 - 2.3e-14 53.8 0.0 4.3e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Trypan_PARP PF05887.11 EFE42823.1 - 0.0028 17.6 5.4 0.0028 17.6 5.4 2.1 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Abhydrolase_1 PF00561.20 EFE42824.1 - 1e-49 169.5 0.4 4.6e-48 164.1 0.4 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EFE42824.1 - 0.0009 19.0 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase ThiF PF00899.21 EFE42825.1 - 1.4e-40 139.2 0.0 2.3e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 ThiF family Metallophos PF00149.28 EFE42825.1 - 2.3e-13 51.1 0.0 4.3e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFE42825.1 - 8e-07 29.4 0.0 2e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Sacchrp_dh_NADP PF03435.18 EFE42825.1 - 0.0028 17.9 1.3 0.029 14.6 1.3 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EFE42825.1 - 0.0092 16.2 0.1 0.028 14.7 0.1 1.9 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 EFE42825.1 - 0.11 12.1 0.1 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EFE42825.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MARVEL PF01284.23 EFE42826.1 - 8.6e-17 61.5 7.7 1.2e-16 61.1 7.7 1.2 1 0 0 1 1 1 1 Membrane-associating domain ABC2_membrane_5 PF13346.6 EFE42826.1 - 0.0089 15.6 2.7 0.018 14.6 2.7 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein DUF2105 PF09878.9 EFE42826.1 - 0.73 9.5 4.2 12 5.5 0.5 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2105) DUF4336 PF14234.6 EFE42827.1 - 3.1e-16 59.5 0.1 3.7e-12 46.1 0.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4336) Nse4_C PF08743.10 EFE42828.1 - 6.3e-32 109.7 0.0 1.3e-31 108.7 0.0 1.5 1 0 0 1 1 1 1 Nse4 C-terminal PI3Ka PF00613.20 EFE42829.1 - 7.9e-59 198.2 0.1 1.3e-58 197.5 0.1 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFE42829.1 - 1e-45 156.5 0.0 1.4e-30 107.0 0.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EFE42829.1 - 2e-32 112.0 0.0 3.3e-32 111.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 HCO3_cotransp PF00955.21 EFE42830.1 - 9.2e-55 186.4 12.1 2.2e-38 132.4 0.6 3.1 1 1 1 2 2 2 2 HCO3- transporter family MMR_HSR1 PF01926.23 EFE42831.1 - 1.3e-12 47.8 0.0 2.7e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFE42831.1 - 3.9e-07 30.1 0.0 8.7e-07 29.0 0.0 1.5 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EFE42831.1 - 0.00025 20.6 0.2 0.00067 19.2 0.2 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 EFE42831.1 - 0.011 16.3 0.0 0.021 15.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EFE42831.1 - 0.035 13.6 0.0 0.087 12.4 0.0 1.6 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MeaB PF03308.16 EFE42831.1 - 0.067 12.2 0.1 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 EFE42831.1 - 0.085 12.0 0.0 2.1 7.5 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Septin PF00735.18 EFE42831.1 - 0.099 11.9 0.0 0.22 10.7 0.0 1.5 2 0 0 2 2 2 0 Septin NTPase_1 PF03266.15 EFE42831.1 - 0.099 12.6 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 NTPase Arf PF00025.21 EFE42831.1 - 0.1 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family TniB PF05621.11 EFE42831.1 - 0.1 12.0 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.13 EFE42831.1 - 0.15 12.3 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Isy1 PF06246.12 EFE42832.1 - 2.5e-86 289.4 0.1 3e-86 289.1 0.1 1.0 1 0 0 1 1 1 1 Isy1-like splicing family CAP59_mtransfer PF11735.8 EFE42833.1 - 1.8e-71 240.7 0.0 2.3e-71 240.3 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 RHH_1 PF01402.21 EFE42834.1 - 0.018 14.9 0.1 0.021 14.8 0.1 1.1 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family GST_N PF02798.20 EFE42837.1 - 2.8e-15 56.4 0.0 9.3e-15 54.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFE42837.1 - 1.5e-13 50.9 0.0 3.6e-13 49.7 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE42837.1 - 1.6e-10 41.2 0.1 4.6e-10 39.7 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFE42837.1 - 3.5e-10 40.0 0.0 7.3e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFE42837.1 - 1.7e-09 37.7 0.0 3.2e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE42837.1 - 3.5e-06 27.0 0.0 8.1e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain APH PF01636.23 EFE42838.1 - 6.5e-07 29.5 0.0 5e-05 23.3 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family HSDR_N_2 PF13588.6 EFE42839.1 - 0.023 14.7 0.0 0.052 13.5 0.0 1.5 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) HSDR_N PF04313.14 EFE42839.1 - 0.1 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Iwr1 PF08574.10 EFE42840.1 - 5.4e-14 53.0 2.8 5.4e-14 53.0 2.8 3.7 2 1 1 3 3 3 1 Transcription factor Iwr1 DDHD PF02862.17 EFE42841.1 - 4.1 7.5 11.2 5.8 7.0 11.2 1.2 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 EFE42841.1 - 9.2 6.2 12.1 12 5.9 12.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 EFE42841.1 - 9.5 4.9 17.3 12 4.6 17.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter TB2_DP1_HVA22 PF03134.19 EFE42842.1 - 3.6e-16 58.8 4.9 5.6e-16 58.2 4.9 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family F-box-like PF12937.7 EFE42843.1 - 6.8e-06 25.9 0.1 1.4e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE42843.1 - 5.7e-05 22.9 0.1 0.00014 21.7 0.1 1.6 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 EFE42843.1 - 0.078 13.3 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 PRANC domain Peptidase_S32 PF05579.13 EFE42844.1 - 0.021 14.0 0.0 0.035 13.3 0.0 1.2 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Trypsin_2 PF13365.6 EFE42844.1 - 0.098 13.6 0.0 0.3 12.0 0.0 1.8 1 1 0 1 1 1 0 Trypsin-like peptidase domain TraC_F_IV PF11130.8 EFE42845.1 - 0.015 14.9 0.0 0.055 13.1 0.0 2.0 2 0 0 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer Glyco_hydro_18 PF00704.28 EFE42847.1 - 4.6e-36 125.1 1.5 6.5e-36 124.6 1.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EFE42847.1 - 1.3e-11 44.3 0.0 1e-07 31.9 0.0 2.6 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 EFE42847.1 - 4.1e-07 30.4 11.2 4.1e-07 30.4 11.2 3.1 2 1 0 2 2 2 1 Chitin recognition protein Peptidase_C1_2 PF03051.15 EFE42847.1 - 0.036 12.8 0.0 0.057 12.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase C1-like family PHO4 PF01384.20 EFE42849.1 - 3.3e-99 332.1 17.2 3.8e-99 331.9 17.2 1.0 1 0 0 1 1 1 1 Phosphate transporter family UPF0444 PF15475.6 EFE42849.1 - 2.6 8.3 8.4 1.7 9.0 0.4 2.8 2 0 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 Pkinase PF00069.25 EFE42851.1 - 7.3e-56 189.5 0.0 9e-56 189.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42851.1 - 6.6e-31 107.5 0.0 8.6e-31 107.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFE42851.1 - 5.4e-06 25.6 0.1 6.3e-06 25.4 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFE42851.1 - 2.7e-05 23.6 0.1 9.4e-05 21.9 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE42851.1 - 0.00031 20.7 0.1 0.0013 18.7 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFE42851.1 - 0.0012 18.3 0.1 0.0038 16.6 0.1 1.7 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EFE42851.1 - 0.0081 15.8 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EFE42851.1 - 0.02 14.5 0.0 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EFE42851.1 - 0.13 11.0 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase CCDC71L PF15374.6 EFE42852.1 - 1 8.5 10.5 1.4 8.1 10.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Ribosomal_S2 PF00318.20 EFE42852.1 - 1.7 7.8 4.0 3.3 6.9 3.7 1.7 1 1 0 1 1 1 0 Ribosomal protein S2 VIT1 PF01988.19 EFE42852.1 - 2.3 8.0 7.3 5.4 6.8 7.3 1.6 1 1 0 1 1 1 0 VIT family Presenilin PF01080.17 EFE42852.1 - 2.7 6.7 14.6 3.7 6.2 14.6 1.1 1 0 0 1 1 1 0 Presenilin ICA69 PF04629.14 EFE42852.1 - 3.4 7.9 11.2 4.7 7.4 11.2 1.1 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain PA26 PF04636.13 EFE42852.1 - 4.5 6.1 6.1 5.7 5.8 6.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Asp-B-Hydro_N PF05279.11 EFE42852.1 - 5.5 7.0 21.3 7.2 6.6 21.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region ALMT PF11744.8 EFE42852.1 - 5.5 5.7 9.7 7.2 5.3 9.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter G-alpha PF00503.20 EFE42853.1 - 6.6e-38 130.8 0.0 8e-38 130.5 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit DAO PF01266.24 EFE42854.1 - 0.00024 20.8 0.0 0.00032 20.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase TBP PF00352.21 EFE42855.1 - 6e-67 221.6 0.2 1.1e-32 111.8 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EFE42855.1 - 4.9e-05 23.4 0.1 0.25 11.5 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function (DUF3378) ETF_QO PF05187.13 EFE42857.1 - 1.5e-47 160.0 0.7 2.4e-47 159.4 0.7 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 EFE42857.1 - 0.0012 18.5 0.0 0.13 11.8 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE42857.1 - 0.0057 16.9 0.0 0.017 15.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Fer4_7 PF12838.7 EFE42857.1 - 0.017 15.7 0.9 0.039 14.5 0.9 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Pyr_redox PF00070.27 EFE42857.1 - 0.079 13.5 0.0 0.2 12.3 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_2 PF12797.7 EFE42857.1 - 0.14 12.3 0.7 0.33 11.1 0.7 1.6 1 0 0 1 1 1 0 4Fe-4S binding domain RRM_1 PF00076.22 EFE42858.1 - 1.8e-05 24.4 0.0 3.6e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FolB PF02152.18 EFE42859.1 - 3.6e-27 95.1 0.8 9.1e-22 77.7 0.5 2.6 3 0 0 3 3 3 2 Dihydroneopterin aldolase Pkinase PF00069.25 EFE42860.1 - 5.1e-66 222.7 0.0 7e-66 222.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42860.1 - 4.9e-30 104.7 0.0 6.8e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFE42860.1 - 0.048 12.6 0.2 0.074 12.0 0.2 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EFE42860.1 - 0.076 11.8 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EFE42860.1 - 0.14 12.1 1.1 3.1 7.6 0.2 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF2767 PF10965.8 EFE42861.1 - 0.018 15.0 0.0 0.053 13.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2767) RdDM_RDM1 PF09187.10 EFE42861.1 - 0.038 14.0 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 RNA-directed DNA methylation 1 APO_RNA-bind PF05634.11 EFE42861.1 - 0.11 11.8 0.0 0.29 10.5 0.0 1.6 1 0 0 1 1 1 0 APO RNA-binding Ndc80_HEC PF03801.13 EFE42862.1 - 2.1e-60 202.8 0.5 4e-60 201.9 0.5 1.5 1 0 0 1 1 1 1 HEC/Ndc80p family DUF812 PF05667.11 EFE42862.1 - 0.012 14.5 31.2 0.013 14.5 13.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Spc7 PF08317.11 EFE42862.1 - 0.022 13.7 40.1 0.21 10.4 18.8 3.0 2 0 0 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EFE42862.1 - 2.1 8.4 44.6 1 9.4 3.7 4.1 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein Cep57_CLD PF14073.6 EFE42862.1 - 3.8 7.5 43.1 0.14 12.1 18.5 3.3 2 1 1 3 3 3 0 Centrosome localisation domain of Cep57 Golgin_A5 PF09787.9 EFE42862.1 - 5.6 6.3 46.5 1.2 8.5 15.1 3.4 2 1 1 3 3 3 0 Golgin subfamily A member 5 CEP63 PF17045.5 EFE42862.1 - 6.3 6.6 39.8 0.96 9.3 12.0 3.3 2 1 1 3 3 3 0 Centrosomal protein of 63 kDa Pex14_N PF04695.13 EFE42863.1 - 7e-29 101.5 0.0 7e-29 101.5 0.0 3.0 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Golgin_A5 PF09787.9 EFE42863.1 - 0.00079 19.0 0.8 0.0013 18.2 0.8 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF3584 PF12128.8 EFE42863.1 - 0.0019 15.8 3.3 0.0028 15.3 3.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) HemX PF04375.14 EFE42863.1 - 0.0087 15.4 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase SYCE1 PF15233.6 EFE42863.1 - 0.021 14.9 3.1 0.034 14.2 3.1 1.3 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 DUF1043 PF06295.12 EFE42863.1 - 0.042 13.8 0.2 0.097 12.7 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) zf-C4H2 PF10146.9 EFE42863.1 - 0.22 11.8 4.9 0.047 14.0 1.2 1.8 2 0 0 2 2 2 0 Zinc finger-containing protein DivIC PF04977.15 EFE42863.1 - 0.3 10.9 1.1 2.9 7.7 0.0 2.5 1 1 1 2 2 2 0 Septum formation initiator DUF1664 PF07889.12 EFE42863.1 - 1.9 8.6 4.2 13 5.8 3.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Myc_N PF01056.18 EFE42864.1 - 7.1 6.4 10.6 1.4 8.7 7.0 1.6 1 1 0 1 1 1 0 Myc amino-terminal region ABC_tran PF00005.27 EFE42865.1 - 1.5e-33 116.2 0.0 3e-33 115.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EFE42865.1 - 5.1e-23 82.1 0.7 5.1e-23 82.1 0.7 2.1 2 1 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EFE42865.1 - 3e-05 23.6 0.2 0.0021 17.6 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFE42865.1 - 0.0032 18.0 0.5 0.015 15.8 0.2 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFE42865.1 - 0.013 15.3 0.2 0.037 13.8 0.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 EFE42865.1 - 0.057 13.7 0.1 0.39 11.0 0.1 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.7 EFE42865.1 - 0.059 12.3 0.0 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain RsgA_GTPase PF03193.16 EFE42865.1 - 0.083 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EFE42865.1 - 0.086 13.1 0.2 0.31 11.3 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EFE42865.1 - 0.2 11.3 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TTL PF03133.15 EFE42866.1 - 2.2e-57 194.4 0.0 3e-57 194.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFE42866.1 - 0.00038 19.8 0.0 0.00076 18.8 0.0 1.5 1 0 0 1 1 1 1 YheC/D like ATP-grasp DUF3848 PF12959.7 EFE42866.1 - 0.11 12.6 0.9 0.62 10.2 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3848) Dala_Dala_lig_C PF07478.13 EFE42866.1 - 0.14 11.6 0.1 0.47 10.0 0.1 1.8 1 1 1 2 2 2 0 D-ala D-ala ligase C-terminus SurE PF01975.17 EFE42867.1 - 1.5e-41 142.4 0.0 1.9e-41 142.0 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE Seipin PF06775.14 EFE42868.1 - 1.3e-43 149.4 0.0 1.6e-43 149.2 0.0 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Not1 PF04054.15 EFE42869.1 - 4.9e-138 460.0 0.7 4.9e-138 460.0 0.7 2.7 3 0 0 3 3 3 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EFE42869.1 - 3.5e-93 311.1 3.5 1.2e-92 309.4 3.5 2.0 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EFE42869.1 - 4.6e-51 172.6 2.0 1e-50 171.5 2.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EFE42869.1 - 1.7e-40 138.3 0.0 6.7e-40 136.3 0.0 2.0 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 EFE42869.1 - 3.1e-29 102.0 0.9 1.3e-28 100.0 0.0 2.4 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat SH3_1 PF00018.28 EFE42870.1 - 1.4e-12 47.0 0.0 3.8e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE42870.1 - 5.4e-11 42.2 0.1 6.2e-10 38.8 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EFE42870.1 - 2e-10 40.2 0.0 8.8e-10 38.1 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain Rapsyn_N PF10579.9 EFE42870.1 - 0.14 12.2 0.1 0.29 11.2 0.1 1.4 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region APG6_N PF17675.1 EFE42870.1 - 7.7 7.0 7.7 3.7 8.1 4.8 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region DASH_Duo1 PF08651.10 EFE42871.1 - 1.1e-31 108.5 0.1 1.8e-31 107.7 0.1 1.4 1 0 0 1 1 1 1 DASH complex subunit Duo1 DUF1509 PF07420.11 EFE42871.1 - 0.0042 16.1 7.8 0.0067 15.4 7.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1509) 3HCDH_N PF02737.18 EFE42871.1 - 0.052 13.4 4.9 0.26 11.1 0.2 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HA2 PF04408.23 EFE42871.1 - 1.3 9.4 8.1 2 8.8 1.2 2.8 2 1 0 2 2 2 0 Helicase associated domain (HA2) OmpH PF03938.14 EFE42871.1 - 3.3 8.1 18.5 4.2 7.7 4.4 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) zf-primase PF09329.11 EFE42873.1 - 5.3e-20 71.0 1.0 9.5e-20 70.2 1.0 1.4 1 0 0 1 1 1 1 Primase zinc finger RNase_H2-Ydr279 PF09468.10 EFE42874.1 - 4.5e-38 130.9 3.5 6.8e-38 130.4 0.2 2.6 1 1 1 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 EFE42874.1 - 2.6e-22 78.9 0.0 6.4e-22 77.6 0.0 1.7 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain HAUS-augmin3 PF14932.6 EFE42874.1 - 0.59 9.7 7.9 0.2 11.2 5.2 1.6 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 GalKase_gal_bdg PF10509.9 EFE42875.1 - 2.7e-18 65.3 0.0 5.6e-18 64.2 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 EFE42875.1 - 4.7e-15 55.7 0.0 9.9e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 EFE42875.1 - 1.3e-13 50.9 1.4 2.5e-13 50.0 1.4 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain DED PF01335.21 EFE42875.1 - 0.084 13.2 0.4 0.26 11.6 0.2 2.0 2 0 0 2 2 2 0 Death effector domain TPP_enzyme_N PF02776.18 EFE42876.1 - 2.8e-54 183.3 0.1 1.3e-52 177.9 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EFE42876.1 - 3.2e-49 166.6 0.4 8.6e-47 158.7 0.0 3.0 3 1 0 3 3 3 2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EFE42876.1 - 1.2e-40 138.4 0.2 3.5e-40 136.9 0.2 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 EFE42876.1 - 0.037 13.8 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg RINGv PF12906.7 EFE42877.1 - 1.3e-05 25.2 5.8 3.3e-05 23.9 5.8 1.7 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 EFE42877.1 - 4.1e-05 23.7 2.9 0.0001 22.4 2.9 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain PhnA_Zn_Ribbon PF08274.12 EFE42877.1 - 0.0055 16.6 1.5 0.013 15.4 1.5 1.7 1 0 0 1 1 1 1 PhnA Zinc-Ribbon zf-TFIIB PF13453.6 EFE42877.1 - 0.021 14.1 0.1 0.049 13.0 0.1 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger zf-RING_2 PF13639.6 EFE42877.1 - 0.03 14.6 4.6 0.099 13.0 4.6 2.0 1 0 0 1 1 1 0 Ring finger domain Ras PF00071.22 EFE42878.1 - 5.5e-31 107.3 0.0 6.2e-31 107.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE42878.1 - 1.7e-12 47.6 0.0 2.5e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Acyl_transf_3 PF01757.22 EFE42881.1 - 1.4e-16 60.5 30.9 2.2e-16 59.9 30.6 1.5 1 1 1 2 2 2 1 Acyltransferase family Peptidase_S24 PF00717.23 EFE42883.1 - 3.3e-08 33.4 0.0 5.1e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like BTB PF00651.31 EFE42884.1 - 1.4e-06 28.5 0.0 6.1e-06 26.4 0.0 2.0 3 0 0 3 3 3 1 BTB/POZ domain Sterol_MT_C PF08498.10 EFE42885.1 - 6.3e-22 77.7 0.1 1.1e-21 76.9 0.1 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EFE42885.1 - 2.1e-15 57.2 0.0 9e-15 55.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE42885.1 - 2e-14 53.6 0.0 4.1e-14 52.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE42885.1 - 4.9e-14 52.8 0.0 2.7e-13 50.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE42885.1 - 5.1e-11 42.7 0.0 8.1e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE42885.1 - 3.2e-09 37.4 0.0 8.4e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE42885.1 - 4.4e-09 36.0 0.0 4.1e-08 32.8 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EFE42885.1 - 1.3e-08 34.5 0.1 6.7e-08 32.1 0.1 1.9 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EFE42885.1 - 0.00045 20.0 0.0 0.00085 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EFE42885.1 - 0.047 13.2 0.0 0.16 11.5 0.0 1.8 1 1 1 2 2 2 0 Methyltransferase small domain DRE2_N PF16803.5 EFE42885.1 - 0.052 13.8 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus Methyltransf_29 PF03141.16 EFE42885.1 - 0.054 12.0 0.0 0.29 9.7 0.0 1.8 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase FtsJ PF01728.19 EFE42885.1 - 0.08 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_15 PF09445.10 EFE42885.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.6 EFE42885.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EFE42885.1 - 0.15 11.4 0.0 0.37 10.1 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) p450 PF00067.22 EFE42886.1 - 1.1e-25 90.3 0.0 1.5e-25 89.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RCC1 PF00415.18 EFE42887.1 - 5.8e-46 154.9 8.8 8.9e-11 42.2 0.0 8.5 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFE42887.1 - 5.2e-35 118.5 27.1 3.2e-07 30.0 1.0 6.7 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat PilO PF04350.13 EFE42888.1 - 0.012 15.7 0.7 0.043 14.0 0.1 1.9 1 1 1 2 2 2 0 Pilus assembly protein, PilO Baculo_PEP_C PF04513.12 EFE42888.1 - 0.019 15.0 0.7 0.019 15.0 0.7 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0184 PF03670.13 EFE42888.1 - 0.057 13.8 0.2 0.16 12.4 0.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) DUF148 PF02520.17 EFE42888.1 - 0.092 12.9 1.0 0.25 11.5 1.0 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF148 CaiF_GrlA PF07180.11 EFE42888.1 - 0.12 12.3 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 CaiF/GrlA transcriptional regulator Med3 PF11593.8 EFE42888.1 - 1.3 8.1 15.8 0.22 10.7 9.4 2.3 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Sds3 PF08598.11 EFE42893.1 - 6.3e-47 160.4 9.9 1.6e-44 152.5 9.9 2.1 1 1 0 1 1 1 1 Sds3-like EPL1 PF10513.9 EFE42894.1 - 0.23 11.8 9.0 2.2 8.6 3.2 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like Paramyxo_C PF01692.18 EFE42897.1 - 0.19 11.1 0.1 0.41 10.0 0.1 1.4 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C zf-C2H2 PF00096.26 EFE42897.1 - 0.35 11.4 1.4 0.53 10.8 0.2 2.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type Phos_pyr_kin PF08543.12 EFE42898.1 - 4.6e-69 232.5 1.6 7.1e-69 231.9 1.6 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EFE42898.1 - 3.9e-32 111.8 1.6 1.5e-21 77.2 0.1 2.4 1 1 1 2 2 2 2 TENA/THI-4/PQQC family PfkB PF00294.24 EFE42898.1 - 3.1e-05 23.4 0.1 0.00076 18.9 0.1 2.3 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 EFE42898.1 - 0.01 15.3 0.2 0.061 12.7 0.1 2.2 3 0 0 3 3 3 0 Hydroxyethylthiazole kinase family DEAD PF00270.29 EFE42899.1 - 3.3e-50 170.3 0.0 4.9e-49 166.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE42899.1 - 1.3e-10 41.6 0.1 1.1e-09 38.6 0.1 2.5 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE42899.1 - 9.2e-05 22.5 0.0 0.00026 21.0 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF5335 PF17269.2 EFE42899.1 - 0.026 14.3 0.1 0.048 13.5 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5335) DUF2443 PF10398.9 EFE42899.1 - 0.11 12.6 0.4 0.22 11.6 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) DUF445 PF04286.12 EFE42899.1 - 0.15 11.9 0.1 0.22 11.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) AAA_19 PF13245.6 EFE42899.1 - 0.15 12.4 0.0 24 5.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFE42899.1 - 0.54 10.5 2.3 17 5.7 0.0 3.0 2 1 1 3 3 3 0 AAA domain PPR_2 PF13041.6 EFE42900.1 - 8e-25 86.8 0.0 5.7e-17 61.7 0.0 2.9 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 EFE42900.1 - 6.2e-10 39.0 0.1 0.00058 19.9 0.0 2.9 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFE42900.1 - 1.1e-06 28.2 0.2 0.42 10.4 0.0 4.0 4 0 0 4 4 4 3 PPR repeat PPR PF01535.20 EFE42900.1 - 1.8e-05 24.7 4.9 0.00019 21.5 0.0 3.9 5 0 0 5 5 5 1 PPR repeat PPR_long PF17177.4 EFE42900.1 - 0.027 13.8 0.0 2.8 7.2 0.0 2.2 1 1 1 2 2 2 0 Pentacotripeptide-repeat region of PRORP EPSP_synthase PF00275.20 EFE42901.1 - 1.5e-130 435.7 0.0 2.5e-130 434.9 0.0 1.4 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 EFE42901.1 - 3e-98 328.2 0.0 5.3e-98 327.4 0.0 1.4 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 EFE42901.1 - 3.1e-57 194.5 0.0 6.8e-57 193.4 0.0 1.6 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 EFE42901.1 - 1.6e-36 125.8 0.0 3.4e-36 124.8 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.11 EFE42901.1 - 7.4e-26 90.2 0.0 2.1e-25 88.8 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Fe-ADH_2 PF13685.6 EFE42901.1 - 2e-06 27.7 0.0 5.6e-06 26.2 0.0 1.8 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Shikimate_DH PF01488.20 EFE42901.1 - 3.6e-05 23.9 0.0 9.5e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_24 PF13479.6 EFE42901.1 - 0.00046 20.0 0.0 0.0012 18.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFE42901.1 - 0.061 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain THF_DHG_CYH PF00763.23 EFE42901.1 - 0.16 12.3 0.0 0.71 10.2 0.1 2.0 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AAA_14 PF13173.6 EFE42901.1 - 0.16 12.0 0.0 0.88 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFE42901.1 - 0.16 12.5 0.0 0.38 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain SDH_C PF18317.1 EFE42901.1 - 0.56 10.0 2.1 9 6.2 0.1 3.0 3 0 0 3 3 3 0 Shikimate 5'-dehydrogenase C-terminal domain XRN_M PF17846.1 EFE42902.1 - 1.7e-152 508.4 0.3 1.7e-152 508.4 0.3 2.1 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 EFE42902.1 - 1.1e-98 329.5 2.7 3.2e-98 328.0 0.0 2.6 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus Uso1_p115_head PF04869.14 EFE42903.1 - 5.7e-110 367.3 0.0 2.6e-109 365.1 0.0 2.2 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EFE42903.1 - 8.3e-18 65.0 31.3 8.3e-18 65.0 31.3 3.5 1 1 2 3 3 3 2 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2570 PF10828.8 EFE42903.1 - 0.56 10.0 32.1 0.22 11.3 8.8 4.0 2 1 2 4 4 4 0 Protein of unknown function (DUF2570) Filament PF00038.21 EFE42903.1 - 1 8.8 51.0 2.3 7.7 50.8 1.6 1 1 0 1 1 1 0 Intermediate filament protein Spc7 PF08317.11 EFE42903.1 - 6 5.7 52.2 0.33 9.8 23.7 2.7 1 1 0 2 2 2 0 Spc7 kinetochore protein tRNA-synt_1 PF00133.22 EFE42904.1 - 4.2e-220 732.1 0.0 5.9e-220 731.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFE42904.1 - 4.7e-24 85.1 0.0 1.5e-23 83.5 0.0 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFE42904.1 - 2.3e-12 46.4 0.0 2.1e-05 23.4 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFE42904.1 - 0.093 12.1 0.0 1.2 8.4 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain p450 PF00067.22 EFE42905.1 - 2.2e-73 247.6 0.0 3.5e-73 246.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EFE42905.1 - 8.9e-27 94.1 0.0 1.5e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFE42905.1 - 3e-21 76.1 0.0 6.7e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFE42905.1 - 2.9e-11 44.0 0.0 6.5e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EFE42905.1 - 0.0017 18.6 0.0 0.0035 17.6 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin domain NAD_binding_6 PF08030.12 EFE42905.1 - 0.19 11.9 0.0 0.38 10.9 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Sfi1 PF08457.10 EFE42906.1 - 1.4e-196 654.4 90.5 5.5e-195 649.2 79.7 2.1 1 1 1 2 2 2 2 Sfi1 spindle body protein Elongin_A PF06881.11 EFE42907.1 - 1e-27 96.7 1.7 1.9e-27 95.9 1.7 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box-like PF12937.7 EFE42908.1 - 0.017 15.0 0.1 0.033 14.1 0.1 1.5 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFE42908.1 - 0.02 14.7 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 F-box domain Stc1 PF12898.7 EFE42908.1 - 0.034 14.7 0.6 0.086 13.4 0.6 1.6 1 0 0 1 1 1 0 Stc1 domain Sugar_tr PF00083.24 EFE42910.1 - 1.2e-71 241.9 19.6 1.6e-71 241.6 19.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE42910.1 - 2e-08 33.5 27.0 2.8e-05 23.2 17.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily EBP PF05241.12 EFE42910.1 - 3.6 7.0 14.2 0.14 11.6 3.5 2.6 2 1 0 2 2 2 0 Emopamil binding protein Band_7 PF01145.25 EFE42911.1 - 7.2e-16 58.7 0.0 7.2e-16 58.7 0.0 2.6 2 1 0 2 2 2 1 SPFH domain / Band 7 family TBCA PF02970.16 EFE42914.1 - 6.3e-25 87.3 14.0 7.2e-25 87.1 13.6 1.3 1 1 0 1 1 1 1 Tubulin binding cofactor A HAUS5 PF14817.6 EFE42914.1 - 0.0088 14.9 9.3 0.011 14.6 9.3 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 AdoMet_Synthase PF01941.19 EFE42914.1 - 0.012 14.4 0.4 0.022 13.6 0.2 1.4 1 1 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) FIVAR PF07554.13 EFE42914.1 - 0.029 15.1 4.2 0.029 15.1 4.2 1.9 1 1 1 2 2 2 0 FIVAR domain DUF948 PF06103.11 EFE42914.1 - 0.06 13.6 0.8 0.06 13.6 0.8 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Exonuc_VII_L PF02601.15 EFE42914.1 - 0.063 12.8 7.5 0.069 12.7 7.5 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Acyl-CoA_dh_2 PF08028.11 EFE42914.1 - 0.17 12.1 3.5 0.24 11.7 3.5 1.1 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain PCRF PF03462.18 EFE42914.1 - 0.18 11.6 7.1 0.22 11.4 7.1 1.1 1 0 0 1 1 1 0 PCRF domain HSP70 PF00012.20 EFE42914.1 - 0.22 9.6 10.0 0.26 9.4 10.0 1.0 1 0 0 1 1 1 0 Hsp70 protein DUF1993 PF09351.10 EFE42914.1 - 0.37 10.9 3.4 0.33 11.1 1.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) FapA PF03961.13 EFE42914.1 - 0.52 8.9 8.3 0.55 8.8 8.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc7 PF08317.11 EFE42914.1 - 0.75 8.6 15.6 0.039 12.8 6.2 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein Tho2 PF11262.8 EFE42914.1 - 1.6 7.9 9.5 1.9 7.6 9.5 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF2570 PF10828.8 EFE42914.1 - 1.8 8.4 7.9 2.6 7.9 7.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) CP12 PF02672.15 EFE42914.1 - 3.6 8.4 11.9 7.5 7.4 2.2 2.8 2 2 0 2 2 2 0 CP12 domain DUF5446 PF17522.2 EFE42914.1 - 3.7 7.8 10.8 5.7 7.2 0.7 2.7 1 1 2 3 3 3 0 Family of unknown function (DUF5446) V_ATPase_I PF01496.19 EFE42914.1 - 3.7 5.3 7.8 4.1 5.2 7.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LMBR1 PF04791.16 EFE42914.1 - 5.9 5.7 4.8 6.5 5.5 4.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 EFE42914.1 - 6.5 5.9 6.8 8.7 5.5 6.8 1.3 1 0 0 1 1 1 0 TMPIT-like protein THOC7 PF05615.13 EFE42915.1 - 5.9e-45 152.8 6.0 5.9e-45 152.8 6.0 2.2 1 1 1 2 2 2 1 Tho complex subunit 7 CCDC92 PF14916.6 EFE42915.1 - 0.003 17.3 0.2 0.0091 15.7 0.2 1.8 1 0 0 1 1 1 1 Coiled-coil domain of unknown function DUF1843 PF08898.10 EFE42915.1 - 0.036 14.6 2.1 0.041 14.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Peroxin-13_N PF04088.13 EFE42915.1 - 0.12 12.7 0.1 0.25 11.6 0.1 1.7 1 0 0 1 1 1 0 Peroxin 13, N-terminal region FUSC PF04632.12 EFE42915.1 - 1.2 7.6 7.4 1.6 7.2 7.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family LMBR1 PF04791.16 EFE42915.1 - 2 7.3 5.9 2.6 6.8 5.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PTR2 PF00854.21 EFE42916.1 - 2.5e-95 319.7 10.9 8.8e-95 317.8 10.9 1.8 1 1 0 1 1 1 1 POT family Malic_M PF03949.15 EFE42917.1 - 4.9e-92 307.9 0.0 6.6e-92 307.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EFE42917.1 - 2.9e-64 216.2 0.0 4.9e-64 215.5 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Kinesin PF00225.23 EFE42919.1 - 1.7e-52 178.4 0.0 5.2e-52 176.8 0.0 1.7 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFE42919.1 - 2.5e-07 30.7 0.0 4.9e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding SAM_PNT PF02198.16 EFE42919.1 - 0.17 11.9 0.0 0.45 10.5 0.0 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain DUF4449 PF14613.6 EFE42920.1 - 8.1e-05 22.8 7.7 0.00011 22.3 0.1 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF4449) Ku_PK_bind PF08785.11 EFE42920.1 - 0.0053 16.9 1.9 0.088 13.0 0.0 3.6 4 0 0 4 4 4 1 Ku C terminal domain like DnaJ PF00226.31 EFE42921.1 - 1.9e-23 82.3 2.4 2.9e-23 81.7 2.4 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 EFE42921.1 - 4e-23 82.1 0.0 5.9e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EFE42921.1 - 3.2e-13 49.8 16.2 5.1e-13 49.2 16.2 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EFE42921.1 - 0.002 18.0 8.9 0.072 13.1 1.7 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EFE42921.1 - 0.069 13.2 6.6 2.2 8.3 1.0 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.14 EFE42921.1 - 2.6 8.1 7.8 15 5.7 1.7 3.7 3 1 0 3 3 3 0 Adenylate kinase, active site lid ADH_zinc_N PF00107.26 EFE42923.1 - 1e-07 32.0 0.0 2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE42923.1 - 0.0011 18.8 0.3 0.0027 17.6 0.3 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFE42923.1 - 0.13 13.4 0.0 0.26 12.4 0.0 1.5 1 1 0 1 1 1 0 Zinc-binding dehydrogenase S4 PF01479.25 EFE42924.1 - 2.3e-11 43.2 0.0 3.9e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EFE42924.1 - 2.4e-08 34.8 0.6 5.6e-08 33.6 0.4 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain PilP PF04351.13 EFE42924.1 - 0.04 13.9 0.0 0.077 12.9 0.0 1.6 2 0 0 2 2 2 0 Pilus assembly protein, PilP Speriolin_C PF15059.6 EFE42924.1 - 0.094 12.8 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Speriolin C-terminus MFS_1 PF07690.16 EFE42926.1 - 8e-32 110.5 25.8 1.1e-31 110.0 25.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2681 PF10883.8 EFE42926.1 - 4.3 7.8 9.2 1.2 9.6 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) Glyco_hydro_16 PF00722.21 EFE42927.1 - 6.9e-44 149.4 0.3 6.9e-44 149.4 0.3 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Laminin_G_3 PF13385.6 EFE42927.1 - 0.0034 17.6 0.3 0.0034 17.6 0.3 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Pkinase PF00069.25 EFE42928.1 - 5.3e-09 35.8 0.0 8.3e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42928.1 - 0.0037 16.6 0.0 0.0052 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFE42928.1 - 0.02 14.2 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE42928.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family tRNA-synt_1b PF00579.25 EFE42929.1 - 1.4e-66 224.8 0.0 2e-66 224.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) PP2C PF00481.21 EFE42930.1 - 8.4e-53 179.6 0.0 1.2e-52 179.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EFE42930.1 - 4.4e-41 138.5 63.2 1.3e-11 44.0 7.7 10.9 7 3 5 12 12 12 10 Leucine rich repeat LRR_4 PF12799.7 EFE42930.1 - 8.1e-37 124.6 67.3 3e-06 27.5 2.3 12.2 7 2 7 14 14 14 13 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 EFE42930.1 - 3.9e-27 95.1 0.0 2.6e-26 92.4 0.0 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 EFE42930.1 - 4e-09 36.2 16.1 0.0039 16.7 1.1 4.7 2 1 3 5 5 5 5 Leucine-rich repeat Ad_cyc_g-alpha PF08509.11 EFE42930.1 - 1.9e-08 33.9 0.0 8.4e-08 31.8 0.0 2.2 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_1 PF00560.33 EFE42930.1 - 5.5e-08 32.3 61.0 2.1 9.2 0.1 15.7 16 2 0 16 16 16 4 Leucine Rich Repeat LRR_5 PF13306.6 EFE42930.1 - 7e-06 26.0 4.4 0.057 13.4 0.2 4.0 3 1 0 4 4 4 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EFE42930.1 - 0.00021 21.1 47.2 4.3 7.7 0.3 13.4 15 0 0 15 15 15 4 Leucine Rich repeat RA PF00788.23 EFE42930.1 - 0.059 14.0 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain MSC PF09402.10 EFE42931.1 - 5.3e-103 345.0 0.0 7.5e-103 344.5 0.0 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EFE42931.1 - 4.4e-16 58.3 0.2 8.4e-16 57.4 0.2 1.5 1 0 0 1 1 1 1 HeH/LEM domain DUF3632 PF12311.8 EFE42932.1 - 4.1e-14 53.4 0.0 5.8e-13 49.6 0.0 2.4 1 1 0 2 2 2 1 Protein of unknown function (DUF3632) UL21a PF17636.2 EFE42932.1 - 0.11 12.5 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 Viral Unique Long protein 21a SpoVAD PF07451.11 EFE42932.1 - 0.2 10.3 0.0 0.28 9.8 0.0 1.1 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) MRNIP PF15749.5 EFE42932.1 - 0.25 12.1 0.2 0.25 12.1 0.2 2.2 2 0 0 2 2 2 0 MRN-interacting protein Pox_Ag35 PF03286.14 EFE42932.1 - 0.35 10.6 8.1 0.34 10.7 0.2 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein UCH_1 PF13423.6 EFE42933.1 - 3.7e-96 322.5 0.7 5e-96 322.1 0.7 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EFE42933.1 - 5e-14 53.2 0.0 5.9e-13 49.7 0.0 2.5 2 0 0 2 2 2 1 Exonuclease UCH PF00443.29 EFE42933.1 - 0.0016 18.0 0.0 0.0068 15.9 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase KH_1 PF00013.29 EFE42934.1 - 1.5e-94 309.9 11.3 1.8e-12 46.9 0.1 13.6 13 2 1 14 14 14 8 KH domain SLS PF14611.6 EFE42934.1 - 3.5e-11 43.4 0.2 0.42 10.4 0.0 7.2 2 2 6 8 8 8 5 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 EFE42934.1 - 2.2e-09 37.0 14.6 0.0024 17.7 0.0 7.4 7 1 0 7 7 7 3 KH domain KH_4 PF13083.6 EFE42934.1 - 0.00034 20.4 5.1 16 5.4 0.1 6.0 7 0 0 7 7 7 1 KH domain BMC PF00936.19 EFE42934.1 - 0.24 11.4 4.8 0.34 10.9 0.2 3.4 4 0 0 4 4 4 0 BMC domain KH_5 PF13184.6 EFE42934.1 - 0.96 9.6 8.9 37 4.5 0.3 5.3 6 0 0 6 6 6 0 NusA-like KH domain Pkinase PF00069.25 EFE42935.1 - 4.2e-69 232.8 0.1 6.8e-69 232.2 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42935.1 - 1.7e-44 152.1 0.0 3.2e-44 151.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EFE42935.1 - 8.5e-22 77.3 0.4 2.3e-21 75.9 0.4 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 EFE42935.1 - 1.4e-06 27.3 0.7 2.5e-06 26.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFE42935.1 - 3.1e-06 26.7 0.0 5.3e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFE42935.1 - 0.027 13.8 0.2 0.063 12.6 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE42935.1 - 0.068 13.1 0.1 0.72 9.7 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSHCT PF08148.12 EFE42935.1 - 0.085 12.5 0.6 0.19 11.4 0.0 1.8 2 0 0 2 2 2 0 DSHCT (NUC185) domain Haspin_kinase PF12330.8 EFE42935.1 - 0.11 11.4 1.2 0.55 9.1 1.2 1.9 1 1 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EFE42935.1 - 0.56 9.8 0.0 0.56 9.8 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SH3_1 PF00018.28 EFE42936.1 - 1.1e-17 63.4 0.1 5.8e-17 61.0 0.0 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EFE42936.1 - 2.5e-15 56.1 0.1 4.7e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFE42936.1 - 3.3e-13 49.1 0.1 8.3e-13 47.8 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain GAT PF03127.14 EFE42936.1 - 2.8e-10 40.4 1.9 5.1e-10 39.5 1.9 1.5 1 0 0 1 1 1 1 GAT domain DUF4598 PF15370.6 EFE42936.1 - 0.0013 19.2 0.5 0.0032 17.9 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4598) UIM PF02809.20 EFE42936.1 - 0.017 15.0 1.4 0.042 13.8 1.4 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif K_trans PF02705.16 EFE42937.1 - 2.4e-152 508.2 20.2 1.4e-118 396.7 12.5 3.0 2 1 0 2 2 2 2 K+ potassium transporter Cyt-b5 PF00173.28 EFE42938.1 - 3.6e-24 84.7 0.1 4.7e-24 84.3 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain GTP_EFTU PF00009.27 EFE42939.1 - 3.7e-50 170.2 0.0 9.2e-50 168.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 EFE42939.1 - 5.6e-20 71.4 8.1 1.1e-19 70.4 8.1 1.4 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.17 EFE42939.1 - 4.4e-09 36.6 0.1 1.9e-08 34.6 0.0 2.3 2 0 0 2 2 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFE42939.1 - 2e-08 34.5 0.0 1.2e-07 32.0 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFE42939.1 - 1.1e-07 31.9 0.0 3.1e-06 27.2 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EFE42939.1 - 9e-05 22.0 0.1 0.032 13.7 0.0 2.5 1 1 1 2 2 2 2 ADP-ribosylation factor family Ras PF00071.22 EFE42939.1 - 0.00088 18.9 0.2 0.019 14.6 0.0 2.3 1 1 1 2 2 2 1 Ras family FeoB_N PF02421.18 EFE42939.1 - 0.00096 18.7 0.2 0.055 13.0 0.2 3.2 3 1 0 3 3 3 1 Ferrous iron transport protein B SRPRB PF09439.10 EFE42939.1 - 0.0037 16.7 0.1 1.1 8.6 0.0 2.5 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EFE42939.1 - 0.0042 17.0 0.4 0.55 10.1 0.2 2.5 2 0 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 EFE42939.1 - 0.0046 16.2 0.6 0.23 10.6 0.0 2.9 3 0 0 3 3 3 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EFE42939.1 - 0.0052 16.2 0.1 0.012 14.9 0.1 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EFE42939.1 - 0.0081 16.4 0.1 3.1 8.0 0.0 2.7 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GramPos_pilinD1 PF16555.5 EFE42939.1 - 0.54 10.4 14.1 0.12 12.5 2.0 2.6 2 1 0 2 2 2 0 Gram-positive pilin subunit D1, N-terminal domain HSP70 PF00012.20 EFE42940.1 - 1.9e-249 828.9 10.2 2.6e-249 828.5 10.2 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFE42940.1 - 2.3e-17 62.8 0.6 3.8e-17 62.1 0.6 1.2 1 0 0 1 1 1 1 MreB/Mbl protein DDR PF08841.10 EFE42940.1 - 0.0027 16.8 0.5 0.033 13.2 0.3 2.1 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Radial_spoke_3 PF06098.11 EFE42940.1 - 0.08 12.2 2.7 0.1 11.9 1.3 1.8 1 1 0 1 1 1 0 Radial spoke protein 3 FGGY_C PF02782.16 EFE42940.1 - 0.091 12.5 0.0 0.24 11.1 0.0 1.7 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain UCH PF00443.29 EFE42941.1 - 3.2e-53 180.9 0.1 4.7e-53 180.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE42941.1 - 1e-17 64.8 0.6 1.1e-14 54.8 0.2 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 EFE42941.1 - 9.9e-05 22.8 0.0 0.00025 21.5 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain VHS PF00790.19 EFE42942.1 - 4.1e-42 143.4 0.4 8.5e-42 142.3 0.4 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EFE42942.1 - 1.3e-05 25.3 0.3 9.1e-05 22.7 0.0 2.4 2 0 0 2 2 2 1 GAT domain UIM PF02809.20 EFE42942.1 - 0.00082 19.1 10.5 0.0015 18.3 1.9 3.1 3 0 0 3 3 3 2 Ubiquitin interaction motif Npa1 PF11707.8 EFE42942.1 - 0.014 14.8 0.4 0.043 13.2 0.1 1.9 1 1 0 1 1 1 0 Ribosome 60S biogenesis N-terminal TCO89 PF10452.9 EFE42943.1 - 0.0054 15.8 17.5 0.018 14.1 2.4 3.3 2 2 0 2 2 2 2 TORC1 subunit TCO89 PBP1_TM PF14812.6 EFE42943.1 - 0.037 14.4 3.8 0.1 13.0 0.5 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RCC1 PF00415.18 EFE42944.1 - 8.1e-25 87.2 0.1 4e-07 30.6 0.0 5.4 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFE42944.1 - 9.8e-14 51.5 0.2 4.5e-08 33.3 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain RCC1_2 PF13540.6 EFE42944.1 - 1.4e-09 37.5 4.9 1.9e-08 33.9 0.1 4.1 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.6 EFE42944.1 - 6.8e-06 26.5 0.1 0.00022 21.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE42944.1 - 0.0032 17.8 0.0 0.082 13.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFE42944.1 - 0.0072 16.9 0.0 0.018 15.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFE42944.1 - 0.013 16.0 0.1 2 9.3 0.0 3.1 2 0 0 2 2 2 0 Ankyrin repeat FXMRP1_C_core PF12235.8 EFE42944.1 - 9.1 6.9 19.5 48 4.6 19.5 2.3 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal ATG13 PF10033.9 EFE42945.1 - 1.6e-61 208.0 0.0 2.5e-61 207.4 0.0 1.3 1 0 0 1 1 1 1 Autophagy-related protein 13 FAD_binding_4 PF01565.23 EFE42946.1 - 1.7e-24 86.1 0.5 3.3e-24 85.2 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE42946.1 - 1.8e-05 24.7 0.1 4.5e-05 23.5 0.1 1.7 1 0 0 1 1 1 1 Berberine and berberine like SET PF00856.28 EFE42947.1 - 1.4e-14 54.8 1.8 6.8e-14 52.6 0.0 2.9 2 2 0 2 2 2 1 SET domain TPR_2 PF07719.17 EFE42947.1 - 0.00032 20.6 6.1 0.042 14.0 0.3 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE42947.1 - 0.0012 19.1 1.8 0.0041 17.4 1.8 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFE42947.1 - 0.0014 18.4 3.9 0.33 10.8 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFE42947.1 - 0.0022 18.1 3.6 0.0091 16.1 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFE42947.1 - 0.0036 18.0 0.0 0.029 15.2 0.0 2.7 1 0 0 1 1 1 1 Tetratricopeptide repeat PDZ_6 PF17820.1 EFE42947.1 - 0.017 15.0 0.0 4.9 7.1 0.0 2.9 3 0 0 3 3 3 0 PDZ domain Sulfotransfer_4 PF17784.1 EFE42948.1 - 1.1e-62 211.7 0.1 1.4e-62 211.3 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EFE42948.1 - 0.025 15.0 0.0 0.049 14.0 0.0 1.6 1 1 0 1 1 1 0 Sulfotransferase family NUC153 PF08159.12 EFE42949.1 - 5.1e-10 39.0 1.1 1.1e-09 37.9 1.1 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EFE42949.1 - 0.00011 22.9 0.2 9 7.4 0.0 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE42949.1 - 0.0058 16.9 0.0 0.037 14.3 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain AbrB-like PF14250.6 EFE42949.1 - 0.073 13.2 0.0 21 5.3 0.0 2.6 2 0 0 2 2 2 0 AbrB-like transcriptional regulator Med13_C PF06333.12 EFE42950.1 - 8.1e-53 179.8 15.4 9.2e-33 113.9 0.3 2.8 1 1 1 2 2 2 2 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 EFE42950.1 - 2.7e-42 145.2 1.6 2.7e-42 145.2 1.6 1.9 2 0 0 2 2 2 1 Mediator complex subunit 13 N-terminal MID_MedPIWI PF18296.1 EFE42950.1 - 4.2e-23 82.4 10.4 6.4e-17 62.2 0.1 3.6 3 1 1 4 4 4 2 MID domain of medPIWI HTH_37 PF13744.6 EFE42951.1 - 0.057 13.4 0.3 0.19 11.7 0.3 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain Shisa PF13908.6 EFE42955.1 - 0.0004 20.7 0.0 0.00052 20.3 0.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Collagen PF01391.18 EFE42955.1 - 0.021 14.5 3.8 0.1 12.3 1.6 2.2 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) SLATT_3 PF18184.1 EFE42955.1 - 0.076 13.1 0.0 0.58 10.3 0.0 2.4 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 CD99L2 PF12301.8 EFE42955.1 - 0.13 12.6 0.2 0.13 12.6 0.2 1.9 1 1 1 2 2 2 0 CD99 antigen like protein 2 DUF1310 PF07006.11 EFE42955.1 - 0.23 11.5 0.5 0.33 10.9 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1310) Cellulase PF00150.18 EFE42956.1 - 1.6e-07 31.0 2.6 8e-07 28.8 2.6 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF3899 PF13038.6 EFE42956.1 - 0.67 10.5 2.9 8.8 6.9 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) ETRAMP PF09716.10 EFE42956.1 - 1.6 8.8 5.4 11 6.2 0.2 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Pkinase PF00069.25 EFE42957.1 - 5.4e-50 170.2 0.0 1.4e-44 152.5 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE42957.1 - 1.2e-24 87.0 0.0 2.8e-23 82.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE42957.1 - 5.7e-06 25.9 0.0 8.6e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFE42957.1 - 6.9e-05 21.8 0.1 0.00058 18.7 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFE42957.1 - 0.012 15.6 1.8 0.02 14.8 0.2 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EFE42957.1 - 0.037 13.4 0.1 0.063 12.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFE42957.1 - 0.076 11.9 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain SNF2_N PF00176.23 EFE42958.1 - 6.5e-67 225.7 0.0 3.6e-65 220.0 0.0 2.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE42958.1 - 8.5e-16 58.3 0.0 3.9e-15 56.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE42958.1 - 1.4e-05 24.9 0.0 4.2e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFE42958.1 - 5.8e-05 23.2 0.0 0.00026 21.0 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit PPV_E1_N PF00524.18 EFE42958.1 - 0.0071 16.8 1.8 0.0071 16.8 1.8 2.6 2 1 0 2 2 2 1 E1 Protein, N terminal domain BSP_II PF05432.11 EFE42958.1 - 4.1 7.0 29.3 1.6 8.4 7.2 2.6 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) PALP PF00291.25 EFE42959.1 - 7.9e-40 137.1 0.3 7.4e-29 101.1 0.1 2.2 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme GRDA PF04723.14 EFE42959.1 - 0.011 15.6 0.1 0.077 12.8 0.1 2.0 2 0 0 2 2 2 0 Glycine reductase complex selenoprotein A MFS_1 PF07690.16 EFE42960.1 - 1.6e-24 86.5 67.6 1.2e-23 83.6 49.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EFE42961.1 - 1.4e-36 126.2 19.4 9.1e-21 74.2 3.9 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFE42961.1 - 3.5e-12 45.6 27.6 0.00014 20.6 9.1 3.1 3 0 0 3 3 3 3 MFS/sugar transport protein MFS_1_like PF12832.7 EFE42961.1 - 1.7e-07 30.4 19.3 6.5e-05 22.0 0.7 2.1 1 1 1 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 EFE42961.1 - 9.3e-05 21.5 21.8 0.00048 19.1 9.8 2.9 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_3 PF05977.13 EFE42961.1 - 0.0066 14.9 3.7 0.0066 14.9 3.7 2.6 3 0 0 3 3 3 2 Transmembrane secretion effector OATP PF03137.20 EFE42961.1 - 0.16 10.3 13.2 0.55 8.4 0.2 3.3 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF3938 PF13074.6 EFE42961.1 - 0.66 10.2 5.2 1.9 8.8 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3938) CoA_binding_3 PF13727.6 EFE42961.1 - 5.3 7.0 10.0 0.61 10.1 4.8 2.1 2 0 0 2 2 2 0 CoA-binding domain SIR2 PF02146.17 EFE42962.1 - 7e-38 130.3 0.0 4.1e-37 127.8 0.0 1.9 1 1 0 1 1 1 1 Sir2 family Pyridox_ox_2 PF12900.7 EFE42963.1 - 4.9e-37 127.1 0.0 8.4e-37 126.3 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase ADH_zinc_N PF00107.26 EFE42964.1 - 1.3e-21 76.9 0.0 2.2e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFE42964.1 - 6e-13 50.0 0.0 1.1e-12 49.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE42964.1 - 3.8e-06 26.8 0.0 1.4e-05 24.9 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain FR47 PF08445.10 EFE42965.1 - 2.8e-09 36.8 0.1 7e-05 22.7 0.0 2.4 1 1 1 2 2 2 2 FR47-like protein Acetyltransf_3 PF13302.7 EFE42965.1 - 8.8e-06 26.4 0.0 2.1e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE42965.1 - 2.2e-05 24.7 0.1 0.00011 22.5 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFE42965.1 - 0.024 15.1 0.0 0.046 14.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFE42965.1 - 0.087 13.0 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Peptidase_M24 PF00557.24 EFE42966.1 - 1.9e-45 155.1 0.0 4e-45 154.1 0.0 1.5 2 0 0 2 2 2 1 Metallopeptidase family M24 AMP_N PF05195.16 EFE42966.1 - 9.5e-13 48.0 0.0 1.5e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Dfp1_Him1_M PF08630.10 EFE42967.1 - 1.6e-36 125.3 0.1 1.6e-36 125.3 0.1 2.4 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 EFE42967.1 - 3.6e-05 23.8 3.6 7.9e-05 22.7 3.6 1.5 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.26 EFE42967.1 - 0.02 15.2 0.1 0.1 13.0 0.0 2.2 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFE42967.1 - 0.021 14.8 0.0 0.054 13.5 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain BRCT_2 PF16589.5 EFE42967.1 - 0.091 13.2 0.0 0.35 11.3 0.0 2.1 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Pantoate_transf PF02548.15 EFE42968.1 - 1.2e-107 359.2 1.3 1.4e-107 358.9 1.3 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EFE42968.1 - 2.1e-10 40.5 0.2 3.8e-10 39.6 0.2 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase YjcQ PF09639.10 EFE42968.1 - 0.15 12.2 0.1 0.33 11.2 0.1 1.5 1 0 0 1 1 1 0 YjcQ protein UQ_con PF00179.26 EFE42969.1 - 4e-05 23.3 0.0 4.6e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LAMTOR PF15454.6 EFE42970.1 - 4.1e-11 43.3 0.4 1.4e-10 41.6 0.0 2.0 2 0 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF2011 PF09428.10 EFE42971.1 - 8.8e-29 99.6 1.3 2.6e-28 98.1 0.0 2.2 2 1 0 2 2 2 1 Fungal protein of unknown function (DUF2011) TRAP-gamma PF07074.12 EFE42971.1 - 0.74 9.4 2.1 1.1 8.8 2.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) D123 PF07065.14 EFE42973.1 - 0.0029 16.8 0.0 0.013 14.7 0.0 1.9 1 1 0 1 1 1 1 D123 R2K_3 PF14243.6 EFE42973.1 - 0.0092 16.0 0.0 0.032 14.2 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 EFE42973.1 - 0.043 13.7 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 Sulfotransfer_3 PF13469.6 EFE42974.1 - 0.022 15.2 0.0 0.47 10.8 0.0 2.2 2 0 0 2 2 2 0 Sulfotransferase family Cerato-platanin PF07249.12 EFE42975.1 - 2.5e-43 147.0 0.2 3.6e-43 146.5 0.2 1.2 1 0 0 1 1 1 1 Cerato-platanin Barwin PF00967.17 EFE42975.1 - 0.023 14.6 0.1 0.038 13.9 0.1 1.5 1 1 0 1 1 1 0 Barwin family MFS_1 PF07690.16 EFE42976.1 - 3.7e-46 157.7 45.2 3.7e-46 157.7 45.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE42976.1 - 1.1e-15 57.4 13.7 1.1e-15 57.4 13.7 2.9 3 0 0 3 3 3 2 Sugar (and other) transporter RICTOR_V PF14668.6 EFE42976.1 - 0.037 14.3 0.0 0.12 12.7 0.0 1.9 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 MFS_1_like PF12832.7 EFE42976.1 - 0.4 9.5 27.1 0.015 14.2 10.3 2.7 2 1 0 2 2 2 0 MFS_1 like family Flavoprotein PF02441.19 EFE42977.1 - 1.5e-12 47.5 0.0 2.4e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Flavoprotein Ank_4 PF13637.6 EFE42977.1 - 0.0078 16.8 0.1 42 4.9 0.0 4.4 3 1 3 6 6 6 1 Ankyrin repeats (many copies) Peptidase_S8 PF00082.22 EFE42978.1 - 2.1e-28 99.5 13.4 5.7e-28 98.0 13.4 1.6 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE42978.1 - 3.1e-17 63.0 0.0 5.1e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 p450 PF00067.22 EFE42979.1 - 3.9e-62 210.5 0.0 4.8e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Asparaginase_2 PF01112.18 EFE42980.1 - 1.3e-50 172.2 0.0 4.2e-49 167.2 0.0 3.1 2 1 0 2 2 2 1 Asparaginase Tim17 PF02466.19 EFE42981.1 - 7.6e-29 100.3 5.8 9.7e-29 100.0 5.8 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family MOSC_N PF03476.16 EFE42982.1 - 4.7e-09 36.1 0.0 2.4e-08 33.8 0.0 2.0 2 0 0 2 2 2 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 EFE42982.1 - 3.8e-05 23.7 0.0 6.4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 MOSC domain Amidase PF01425.21 EFE42983.1 - 7.6e-65 219.6 0.0 8.9e-64 216.1 0.0 2.0 1 1 0 1 1 1 1 Amidase Rad51 PF08423.11 EFE42984.1 - 4.8e-12 45.7 0.0 4.6e-11 42.5 0.0 2.2 2 1 0 2 2 2 1 Rad51 RecA PF00154.21 EFE42984.1 - 8.7e-05 22.1 0.0 0.00015 21.3 0.0 1.5 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EFE42984.1 - 0.00011 21.7 1.0 0.00036 19.9 0.0 2.2 2 1 0 2 2 2 1 KaiC PhoH PF02562.16 EFE42984.1 - 0.00027 20.5 0.0 0.00044 19.8 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein AAA_25 PF13481.6 EFE42984.1 - 0.0005 19.7 0.8 0.007 16.0 0.1 2.8 3 1 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EFE42984.1 - 0.0027 17.5 0.0 0.0045 16.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase_2 PF01637.18 EFE42984.1 - 0.0061 16.5 0.1 0.015 15.2 0.0 1.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EFE42984.1 - 0.0078 16.6 0.4 0.018 15.4 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 EFE42984.1 - 0.0094 16.5 0.9 0.04 14.4 0.0 2.1 2 0 0 2 2 2 1 ABC transporter RNA12 PF10443.9 EFE42984.1 - 0.013 14.3 1.0 0.061 12.0 0.0 2.3 3 0 0 3 3 3 0 RNA12 protein CbiA PF01656.23 EFE42984.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.6 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Zot PF05707.12 EFE42984.1 - 0.22 11.1 0.0 0.36 10.4 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) FA_desaturase PF00487.24 EFE42985.1 - 7.4e-18 65.3 15.3 1.4e-17 64.4 15.3 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFE42985.1 - 1.7e-17 63.3 0.1 4.5e-17 62.0 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF1189 PF06691.11 EFE42985.1 - 0.019 14.5 0.1 0.036 13.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Eaf7 PF07904.13 EFE42985.1 - 1 9.8 2.8 3.5 8.0 0.2 2.2 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 Peptidase_M3 PF01432.20 EFE42986.1 - 5e-165 550.2 0.3 6.7e-165 549.8 0.3 1.2 1 0 0 1 1 1 1 Peptidase family M3 SDA1 PF05285.12 EFE42987.1 - 0.0029 17.1 6.6 0.0038 16.7 6.6 1.3 1 0 0 1 1 1 1 SDA1 BSP_II PF05432.11 EFE42987.1 - 0.018 14.8 10.4 0.018 14.8 10.4 1.6 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Eapp_C PF10238.9 EFE42987.1 - 0.026 14.6 2.3 0.16 12.1 0.4 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein CDC45 PF02724.14 EFE42987.1 - 0.04 12.2 5.9 0.053 11.8 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 EFE42987.1 - 0.052 12.4 1.9 0.067 12.0 1.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain YABBY PF04690.13 EFE42987.1 - 0.067 13.8 1.6 10 6.7 1.3 2.6 2 1 0 2 2 2 0 YABBY protein DUF4637 PF15470.6 EFE42987.1 - 0.12 12.0 9.6 0.059 13.1 7.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) PI3K_1B_p101 PF10486.9 EFE42987.1 - 0.13 10.0 6.3 0.19 9.5 6.3 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DNA_pol_phi PF04931.13 EFE42987.1 - 0.21 9.6 9.8 0.25 9.4 9.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 EFE42987.1 - 0.24 10.6 2.6 0.35 10.0 2.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 EFE42987.1 - 0.56 8.9 3.4 0.69 8.6 3.4 1.2 1 0 0 1 1 1 0 Presenilin FAM163 PF15069.6 EFE42987.1 - 0.65 10.4 3.0 0.64 10.4 1.3 1.7 2 0 0 2 2 2 0 FAM163 family FAM176 PF14851.6 EFE42987.1 - 0.85 9.3 6.7 1.8 8.2 6.7 1.6 1 0 0 1 1 1 0 FAM176 family Nop14 PF04147.12 EFE42987.1 - 1.1 7.4 14.9 1.6 6.9 14.9 1.1 1 0 0 1 1 1 0 Nop14-like family DUF3408 PF11888.8 EFE42987.1 - 1.5 9.0 9.4 0.22 11.7 3.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Nucleo_P87 PF07267.11 EFE42987.1 - 7.9 5.2 6.2 9.6 4.9 6.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PRP38_assoc PF12871.7 EFE42987.1 - 9.1 7.0 20.3 0.37 11.4 13.1 2.1 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term EF-hand_7 PF13499.6 EFE42988.1 - 8e-12 45.4 0.0 2.1e-07 31.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EFE42988.1 - 4.3e-11 43.0 0.0 3.2e-05 24.2 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 EFE42988.1 - 8.2e-09 34.7 0.1 0.01 15.7 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EFE42988.1 - 6.4e-08 31.6 0.0 0.018 14.6 0.0 3.4 3 1 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFE42988.1 - 4.3e-06 26.5 0.1 0.00014 21.6 0.0 2.8 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_14 PF17959.1 EFE42988.1 - 0.055 13.8 0.0 5.7 7.4 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain DUF3216 PF11505.8 EFE42988.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) Fungal_trans PF04082.18 EFE42989.1 - 4.8e-64 216.0 0.4 1.2e-63 214.7 0.4 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EFE42989.1 - 0.00037 20.8 14.7 0.0054 17.1 3.8 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 EFE42989.1 - 0.012 15.9 1.7 0.038 14.3 1.7 1.9 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 EFE42989.1 - 6.8 7.8 19.9 0.35 11.8 3.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFE42989.1 - 10 6.8 10.4 2 9.0 2.7 2.7 2 0 0 2 2 2 0 Zinc-finger double domain Glyco_transf_90 PF05686.12 EFE42991.1 - 4.1e-13 49.0 1.3 4.4e-12 45.6 0.7 2.6 2 1 0 2 2 2 1 Glycosyl transferase family 90 Xpo1 PF08389.12 EFE42992.1 - 1e-22 80.8 0.1 2.2e-21 76.5 0.1 3.0 2 0 0 2 2 2 1 Exportin 1-like protein HEAT_2 PF13646.6 EFE42992.1 - 0.0046 17.3 0.0 0.024 15.0 0.0 2.3 1 0 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.6 EFE42992.1 - 0.014 15.9 0.0 0.21 12.2 0.0 3.1 2 0 0 2 2 2 0 HEAT-like repeat GAT PF03127.14 EFE42992.1 - 0.028 14.7 0.0 2.1 8.7 0.0 2.8 2 0 0 2 2 2 0 GAT domain HEAT PF02985.22 EFE42992.1 - 0.03 14.6 0.0 20 5.8 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat 5-FTHF_cyc-lig PF01812.20 EFE42993.1 - 6.2e-20 71.8 0.0 2.4e-19 69.9 0.0 1.9 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Sgf11_N PF18519.1 EFE42993.1 - 0.057 13.0 0.4 0.21 11.1 0.0 2.1 3 0 0 3 3 3 0 SAGA-associated factor 11 N-terminal domain NOA36 PF06524.12 EFE42994.1 - 0.058 12.7 0.7 0.062 12.6 0.7 1.0 1 0 0 1 1 1 0 NOA36 protein Pep1_7 PF17232.2 EFE42994.1 - 0.063 13.7 4.3 0.076 13.5 1.9 2.1 2 0 0 2 2 2 0 Elicitor peptide 1-7 EBV-NA3 PF05009.12 EFE42994.1 - 0.087 12.3 1.7 0.11 12.1 1.7 1.1 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) DUF778 PF05608.12 EFE42994.1 - 0.37 11.1 2.8 0.44 10.9 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF778) Presenilin PF01080.17 EFE42994.1 - 1.9 7.2 3.2 2 7.1 3.2 1.1 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 EFE42994.1 - 2.2 7.9 7.6 2.7 7.6 7.3 1.3 1 1 0 1 1 1 0 FAM176 family Rot1 PF10681.9 EFE42995.1 - 2.1e-86 288.7 0.8 6.4e-86 287.2 0.8 1.6 1 1 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal YqeY PF09424.10 EFE42996.1 - 2.1e-21 76.5 5.6 2.5e-21 76.3 5.6 1.1 1 0 0 1 1 1 1 Yqey-like protein Ino80_Iec3 PF14612.6 EFE42996.1 - 0.078 13.6 0.7 0.1 13.3 0.7 1.2 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling Nucleoporin_N PF08801.11 EFE42997.1 - 2.5e-86 290.1 0.5 3.7e-86 289.6 0.5 1.3 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EFE42997.1 - 1.9e-44 152.4 1.3 1.4e-43 149.5 0.5 2.0 2 0 0 2 2 2 1 Non-repetitive/WGA-negative nucleoporin C-terminal Fungal_lectin PF07938.12 EFE42997.1 - 0.14 11.5 0.0 0.39 10.1 0.0 1.6 1 1 0 1 1 1 0 Fungal fucose-specific lectin DUF2781 PF10914.8 EFE42998.1 - 1.6e-23 83.8 7.2 2.6e-23 83.1 7.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) NAT PF04768.13 EFE42999.1 - 6.7e-51 172.3 0.0 1.5e-50 171.2 0.0 1.4 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Pyr_redox_2 PF07992.14 EFE43000.1 - 1.8e-36 125.9 0.0 2.3e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE43000.1 - 6e-17 62.0 0.0 1.6e-12 47.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE43000.1 - 4.4e-09 36.0 0.0 3.9e-06 26.4 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFE43000.1 - 3e-06 27.4 0.0 0.0033 17.6 0.0 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFE43000.1 - 1.2e-05 24.6 0.0 0.00082 18.6 0.0 2.3 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFE43000.1 - 2.4e-05 24.4 0.3 0.032 14.2 0.0 3.6 3 1 1 4 4 4 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EFE43000.1 - 0.00031 19.7 0.0 4.9 5.9 0.0 3.1 2 1 0 3 3 3 3 Tryptophan halogenase DAO PF01266.24 EFE43000.1 - 0.00038 20.2 0.1 1.7 8.1 0.1 3.0 2 1 1 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EFE43000.1 - 0.00059 18.7 0.0 0.23 10.1 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein Lycopene_cycl PF05834.12 EFE43000.1 - 0.00074 18.7 0.0 0.73 8.8 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein TrkA_N PF02254.18 EFE43000.1 - 0.00097 19.4 0.0 1.1 9.6 0.0 2.4 2 0 0 2 2 2 2 TrkA-N domain DUF1188 PF06690.11 EFE43000.1 - 0.0033 17.0 0.0 0.02 14.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) FAD_binding_3 PF01494.19 EFE43000.1 - 0.012 14.9 0.0 0.46 9.7 0.0 2.4 2 1 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.6 EFE43000.1 - 0.015 15.7 0.0 1.5 9.3 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding p450 PF00067.22 EFE43001.1 - 8e-61 206.2 0.0 1e-60 205.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TPR_12 PF13424.6 EFE43002.1 - 4.3e-40 135.9 11.4 6.4e-12 45.6 1.2 7.6 2 1 4 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 EFE43002.1 - 4.5e-32 109.0 8.6 0.00056 19.7 0.1 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat Helo_like_N PF17111.5 EFE43002.1 - 3e-09 36.6 1.2 3e-09 36.6 1.2 2.5 3 1 0 3 3 3 1 Fungal N-terminal domain of STAND proteins TPR_MalT PF17874.1 EFE43002.1 - 3.7e-09 36.4 3.4 0.00053 19.5 0.0 3.0 2 1 2 4 4 4 2 MalT-like TPR region TPR_2 PF07719.17 EFE43002.1 - 1.4e-08 34.2 6.4 0.44 10.8 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFE43002.1 - 7e-08 32.9 10.4 0.2 12.2 0.0 6.6 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFE43002.1 - 8e-06 25.5 6.0 5.7 7.2 0.0 6.8 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFE43002.1 - 2.1e-05 25.0 12.7 0.59 10.8 1.0 5.9 7 1 0 7 7 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFE43002.1 - 2.7e-05 24.0 2.2 18 5.9 0.1 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFE43002.1 - 5.5e-05 23.4 14.5 0.21 12.3 0.6 6.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFE43002.1 - 0.00029 21.4 12.3 4.3 8.4 0.1 7.1 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFE43002.1 - 0.00031 20.4 6.2 0.17 11.7 0.1 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat NB-ARC PF00931.22 EFE43002.1 - 0.00072 18.8 0.0 0.0017 17.6 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain DUF3427 PF11907.8 EFE43002.1 - 0.0023 17.3 0.2 0.0052 16.1 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3427) DUF1664 PF07889.12 EFE43002.1 - 0.0063 16.6 8.1 0.24 11.4 0.2 4.5 3 1 1 4 4 4 1 Protein of unknown function (DUF1664) ATPase_2 PF01637.18 EFE43002.1 - 0.014 15.3 0.0 0.15 12.0 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EFE43002.1 - 0.019 14.9 0.0 0.054 13.4 0.0 1.8 1 0 0 1 1 1 0 NACHT domain Arf PF00025.21 EFE43002.1 - 0.051 13.0 0.0 0.17 11.3 0.0 1.7 1 1 0 1 1 1 0 ADP-ribosylation factor family Halo_GVPC PF05465.13 EFE43002.1 - 0.076 13.3 0.2 0.21 11.9 0.1 1.8 2 0 0 2 2 1 0 Halobacterial gas vesicle protein C (GVPC) repeat AAA_24 PF13479.6 EFE43002.1 - 0.15 11.7 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain FlgN PF05130.12 EFE43002.1 - 0.35 11.4 0.0 0.35 11.4 0.0 3.2 4 0 0 4 4 4 0 FlgN protein TPR_6 PF13174.6 EFE43002.1 - 4.5 8.1 8.7 17 6.3 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Arv1 PF04161.13 EFE43003.1 - 2.1e-45 155.5 6.7 3.8e-33 115.4 7.2 3.2 2 1 0 2 2 2 2 Arv1-like family DUF1180 PF06679.12 EFE43003.1 - 1.1 9.6 4.6 2.6 8.4 4.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Dabb PF07876.12 EFE43004.1 - 1.7e-15 57.4 0.0 1.9e-15 57.3 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DUF4123 PF13503.6 EFE43004.1 - 0.16 12.4 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4123) DUF3810 PF12725.7 EFE43005.1 - 0.044 13.1 0.2 0.044 13.1 0.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3810) Aminotran_3 PF00202.21 EFE43006.1 - 1.3e-82 277.6 0.0 1.6e-82 277.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III BAR_2 PF10455.9 EFE43007.1 - 1.5e-61 208.1 0.4 2.3e-61 207.5 0.4 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EFE43007.1 - 2.6e-20 73.1 5.4 6.2e-19 68.6 5.4 2.0 1 1 0 1 1 1 1 BAR domain ApoLp-III PF07464.11 EFE43007.1 - 0.01 16.0 2.5 0.38 10.8 0.1 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) GAS PF13851.6 EFE43007.1 - 0.033 13.5 0.9 6.7 6.0 0.4 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding TetR_C_24 PF17932.1 EFE43007.1 - 0.05 13.9 0.1 0.17 12.2 0.0 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain BAR_3 PF16746.5 EFE43007.1 - 0.056 13.1 0.5 0.62 9.7 0.0 2.3 2 0 0 2 2 2 0 BAR domain of APPL family PI3K_1B_p101 PF10486.9 EFE43009.1 - 0.035 11.9 5.3 0.048 11.4 5.3 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CAC1F_C PF16885.5 EFE43009.1 - 0.043 13.5 5.2 0.053 13.2 5.2 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term CENP-B_dimeris PF09026.10 EFE43009.1 - 0.072 13.5 1.6 0.13 12.7 1.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Radial_spoke PF04712.12 EFE43009.1 - 0.09 11.7 7.6 0.17 10.8 2.9 2.0 2 0 0 2 2 2 0 Radial spokehead-like protein Hydin_ADK PF17213.3 EFE43009.1 - 0.14 12.5 3.9 0.2 12.0 3.9 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain FAM176 PF14851.6 EFE43009.1 - 0.62 9.7 9.6 1.4 8.6 1.5 2.2 2 0 0 2 2 2 0 FAM176 family RR_TM4-6 PF06459.12 EFE43009.1 - 2.2 8.1 10.0 3.4 7.4 10.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Jak1_Phl PF17887.1 EFE43009.1 - 4.9 7.1 7.6 0.25 11.3 2.4 1.5 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain Glyco_hydro_72 PF03198.14 EFE43010.1 - 1.6e-118 395.5 1.7 2.1e-118 395.2 1.7 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EFE43010.1 - 7.9e-23 80.9 0.3 2.2e-22 79.5 0.3 1.8 1 0 0 1 1 1 1 X8 domain Glyco_hydro_2_C PF02836.17 EFE43010.1 - 0.019 14.1 0.6 0.093 11.8 0.6 2.1 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 EFE43010.1 - 0.054 12.9 0.6 8 5.8 0.1 2.4 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) Sulfatase PF00884.23 EFE43012.1 - 6.4e-21 75.0 0.3 1.4e-20 74.0 0.3 1.5 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EFE43012.1 - 5.9e-06 26.1 0.0 1.1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EFE43012.1 - 0.0083 14.8 0.0 0.013 14.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) JmjC PF02373.22 EFE43013.1 - 5.6e-06 26.8 0.0 1.4e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 EFE43013.1 - 2.7e-05 24.3 12.5 2.7e-05 24.3 12.5 2.4 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 ZZ PF00569.17 EFE43013.1 - 0.00033 20.4 7.5 0.00033 20.4 7.5 2.8 2 1 0 2 2 2 1 Zinc finger, ZZ type Baculo_IE-1 PF05290.11 EFE43013.1 - 0.049 13.6 8.0 0.027 14.4 1.3 2.3 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) Cupin_2 PF07883.11 EFE43013.1 - 0.14 11.8 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Polyketide_cyc PF03364.20 EFE43015.1 - 3e-19 69.5 0.0 5.9e-19 68.6 0.0 1.5 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sod_Fe_C PF02777.18 EFE43016.1 - 1.6e-18 66.8 0.0 7.3e-08 32.5 0.0 2.2 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain PIG-S PF10510.9 EFE43017.1 - 2.1e-181 604.2 4.7 2.7e-181 603.9 4.7 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein GCIP PF13324.6 EFE43017.1 - 0.11 12.1 0.2 9.9 5.7 0.0 2.3 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting ANAPC4_WD40 PF12894.7 EFE43018.1 - 1.3e-06 28.6 0.0 0.002 18.4 0.0 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain YL1 PF05764.13 EFE43018.1 - 0.0018 18.4 5.6 0.0025 18.0 5.6 1.1 1 0 0 1 1 1 1 YL1 nuclear protein TLP-20 PF06088.11 EFE43018.1 - 0.0083 16.0 1.8 0.013 15.4 1.8 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CDC45 PF02724.14 EFE43018.1 - 0.063 11.6 6.3 0.086 11.1 6.3 1.1 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 EFE43018.1 - 0.53 10.0 4.6 0.8 9.4 4.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 WD40 PF00400.32 EFE43018.1 - 0.84 10.6 7.8 1.2e+02 3.8 0.1 5.3 6 0 0 6 6 6 0 WD domain, G-beta repeat PQQ_3 PF13570.6 EFE43018.1 - 1 10.0 5.9 4 8.1 0.1 3.9 3 1 1 4 4 4 0 PQQ-like domain NOA36 PF06524.12 EFE43018.1 - 1.1 8.5 7.7 1.7 7.9 7.7 1.2 1 0 0 1 1 1 0 NOA36 protein Pes-10 PF07149.11 EFE43018.1 - 1.2 8.1 2.6 1.5 7.8 2.6 1.1 1 0 0 1 1 1 0 Pes-10 FAM176 PF14851.6 EFE43018.1 - 1.9 8.1 4.7 3.2 7.4 4.7 1.3 1 0 0 1 1 1 0 FAM176 family Med19 PF10278.9 EFE43018.1 - 4.7 7.1 9.1 1.3e+02 2.4 9.6 2.1 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Fe-ADH PF00465.19 EFE43019.1 - 5e-79 265.7 1.2 5.7e-79 265.6 1.2 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EFE43019.1 - 1.7e-15 57.4 0.2 2.4e-15 56.9 0.2 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase UPF0261 PF06792.11 EFE43019.1 - 0.0048 15.9 0.0 0.0075 15.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) Diphthamide_syn PF01866.17 EFE43020.1 - 2.6e-85 286.5 0.0 4.9e-85 285.6 0.0 1.4 1 1 0 1 1 1 1 Putative diphthamide synthesis protein Methyltransf_12 PF08242.12 EFE43023.1 - 1.1e-15 58.2 0.0 4.7e-15 56.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE43023.1 - 9.8e-14 51.8 0.0 2.1e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE43023.1 - 5.4e-12 46.2 0.0 1.3e-11 45.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE43023.1 - 4e-11 43.0 0.0 7.2e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE43023.1 - 1.8e-08 34.3 0.0 3e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE43023.1 - 4.6e-05 22.9 0.0 7.6e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 EFE43023.1 - 0.0001 21.6 0.0 0.015 14.5 0.0 2.1 1 1 1 2 2 2 2 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 EFE43023.1 - 0.00063 20.7 0.0 0.0014 19.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFE43023.1 - 0.0018 17.9 0.1 0.0028 17.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EFE43023.1 - 0.0093 15.7 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase CMAS PF02353.20 EFE43023.1 - 0.052 12.8 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_8 PF05148.15 EFE43023.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase DUF3419 PF11899.8 EFE43023.1 - 0.084 12.0 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) TehB PF03848.14 EFE43023.1 - 0.096 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 EFE43023.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Sugar_tr PF00083.24 EFE43024.1 - 9.4e-94 314.8 21.8 2.2e-90 303.7 21.8 3.2 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE43024.1 - 5.8e-14 51.8 40.5 3.7e-08 32.7 24.3 2.8 2 1 0 3 3 3 2 Major Facilitator Superfamily HlyIII PF03006.20 EFE43025.1 - 4.5e-61 206.4 22.1 5.7e-61 206.1 22.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related Asr PF06392.11 EFE43025.1 - 0.055 13.9 0.7 0.1 13.0 0.7 1.4 1 0 0 1 1 1 0 Acid shock protein repeat GlnD_UR_UTase PF08335.11 EFE43025.1 - 0.69 10.0 5.3 2 8.5 0.8 2.2 1 1 1 2 2 2 0 GlnD PII-uridylyltransferase FmiP_Thoc5 PF09766.9 EFE43026.1 - 6.6e-30 104.6 12.2 1e-29 104.0 12.2 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 SPATA1_C PF15743.5 EFE43026.1 - 0.002 18.2 4.1 0.002 18.2 0.6 2.3 2 0 0 2 2 2 1 Spermatogenesis-associated C-terminus DUF948 PF06103.11 EFE43026.1 - 0.049 13.9 0.8 0.49 10.7 0.0 2.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 EFE43026.1 - 0.1 13.1 16.7 0.91 10.1 8.1 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region LCD1 PF09798.9 EFE43026.1 - 0.15 10.6 6.5 0.19 10.2 6.5 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF4200 PF13863.6 EFE43026.1 - 0.17 12.3 13.1 0.19 12.2 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Casc1_N PF15927.5 EFE43026.1 - 0.26 11.0 15.1 0.11 12.1 6.5 2.4 2 1 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus CREPT PF16566.5 EFE43026.1 - 0.41 10.8 8.0 1.6 8.9 1.3 2.3 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour YabA PF06156.13 EFE43026.1 - 3.2 8.4 9.7 4.8 7.9 1.1 2.5 2 1 0 2 2 2 0 Initiation control protein YabA DUF4140 PF13600.6 EFE43026.1 - 3.4 8.1 9.5 6.4 7.3 0.3 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF349 PF03993.12 EFE43026.1 - 5.8 7.3 12.1 0.56 10.5 5.8 2.4 2 1 1 3 3 3 0 Domain of Unknown Function (DUF349) DIE2_ALG10 PF04922.12 EFE43027.1 - 4.2e-57 194.2 0.1 5e-57 194.0 0.1 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family Sld5 PF05916.11 EFE43028.1 - 1.1e-32 112.7 0.0 2.8e-32 111.4 0.0 1.6 1 1 0 1 1 1 1 GINS complex protein CUE PF02845.16 EFE43029.1 - 4.5e-10 39.0 0.0 6.9e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 CUE domain G2BR PF18442.1 EFE43029.1 - 0.025 14.2 11.1 0.045 13.4 11.1 1.4 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) SMC_N PF02463.19 EFE43030.1 - 2.3e-46 158.0 0.0 1.1e-45 155.8 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFE43030.1 - 2.4e-20 73.0 1.3 1.6e-19 70.3 0.4 2.8 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EFE43030.1 - 8e-05 22.6 5.2 0.00054 19.9 0.0 2.9 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MscS_porin PF12795.7 EFE43030.1 - 0.0019 17.8 18.0 0.0019 17.8 18.0 5.6 3 2 2 5 5 5 1 Mechanosensitive ion channel porin domain HIP1_clath_bdg PF16515.5 EFE43030.1 - 0.0056 17.3 11.2 0.0056 17.3 11.2 8.9 3 2 6 10 10 10 1 Clathrin-binding domain of Huntingtin-interacting protein 1 GAS PF13851.6 EFE43030.1 - 0.0071 15.7 9.2 0.0071 15.7 9.2 7.3 2 2 5 7 7 7 2 Growth-arrest specific micro-tubule binding GDI PF00996.18 EFE43031.1 - 3.9e-163 543.0 0.0 4.8e-163 542.7 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NOT2_3_5 PF04153.18 EFE43033.1 - 2.6e-27 95.5 0.1 2.6e-27 95.5 0.1 2.2 2 1 0 2 2 2 1 NOT2 / NOT3 / NOT5 family CDC73_C PF05179.14 EFE43034.1 - 3.3e-58 195.8 0.0 9.1e-58 194.4 0.0 1.8 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal X PF00739.19 EFE43034.1 - 0.15 12.2 0.1 0.15 12.2 0.1 2.3 3 0 0 3 3 3 0 Trans-activation protein X RGS PF00615.19 EFE43035.1 - 8.6e-31 106.7 0.0 2.7e-30 105.1 0.0 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 EFE43035.1 - 5.8e-25 87.2 0.1 1.9e-18 66.3 0.0 3.4 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SprA-related PF12118.8 EFE43035.1 - 0.14 11.3 21.1 0.27 10.3 21.1 1.4 1 0 0 1 1 1 0 SprA-related family TFIIA PF03153.13 EFE43035.1 - 0.31 11.0 16.2 0.44 10.5 16.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RAP1 PF07218.11 EFE43035.1 - 1.8 6.7 11.0 3.3 5.9 11.0 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MAP70 PF07058.11 EFE43035.1 - 8.7 4.9 13.9 13 4.3 13.9 1.2 1 0 0 1 1 1 0 Microtubule-associated protein 70 Rrn6 PF10214.9 EFE43036.1 - 0.033 12.7 0.4 0.031 12.8 0.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CSRNP_N PF16019.5 EFE43036.1 - 0.033 14.1 3.2 0.04 13.8 3.2 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Tankyrase_bdg_C PF15327.6 EFE43036.1 - 0.045 14.2 6.7 0.058 13.9 6.7 1.1 1 0 0 1 1 1 0 Tankyrase binding protein C terminal domain Nop25 PF09805.9 EFE43036.1 - 0.094 13.2 13.6 0.12 12.9 13.6 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) bHLH-MYC_N PF14215.6 EFE43036.1 - 0.11 12.8 0.6 0.13 12.6 0.6 1.1 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal DUF755 PF05501.11 EFE43036.1 - 0.19 12.0 4.2 0.25 11.6 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) TIM21 PF08294.11 EFE43036.1 - 0.29 11.0 2.8 0.31 10.9 2.8 1.1 1 0 0 1 1 1 0 TIM21 Nop53 PF07767.11 EFE43036.1 - 0.36 10.2 12.9 0.46 9.8 12.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RMI1_N PF08585.12 EFE43036.1 - 0.51 10.1 4.0 0.6 9.8 4.0 1.1 1 0 0 1 1 1 0 RecQ mediated genome instability protein Circo_capsid PF02443.15 EFE43036.1 - 1.3 8.6 9.0 1.3 8.5 9.0 1.1 1 0 0 1 1 1 0 Circovirus capsid protein RPN2_C PF18004.1 EFE43036.1 - 1.3 8.9 7.3 1.6 8.6 7.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CDC27 PF09507.10 EFE43036.1 - 1.9 7.8 9.8 2.3 7.5 9.8 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DDRGK PF09756.9 EFE43036.1 - 4 7.0 17.6 4.8 6.7 17.6 1.0 1 0 0 1 1 1 0 DDRGK domain FXR_C1 PF16096.5 EFE43038.1 - 7.7 6.8 14.0 7.5 6.8 13.8 1.3 1 1 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 Ofd1_CTDD PF10637.9 EFE43040.1 - 4.6e-94 314.5 0.1 1.3e-91 306.5 0.2 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EFE43040.1 - 6e-25 87.7 0.0 2.6e-24 85.7 0.0 2.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EFE43040.1 - 7.7e-14 52.4 0.0 1.7e-13 51.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily BUD22 PF09073.10 EFE43040.1 - 3.2 7.0 20.3 0.059 12.7 8.1 2.3 2 0 0 2 2 2 0 BUD22 APH PF01636.23 EFE43041.1 - 7.2e-10 39.2 0.0 2e-09 37.7 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family COesterase PF00135.28 EFE43043.1 - 9.9e-79 265.5 0.0 1.3e-78 265.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE43043.1 - 2.5e-06 27.5 0.1 2.6e-05 24.2 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFE43043.1 - 0.22 11.0 0.1 0.34 10.3 0.1 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family p450 PF00067.22 EFE43044.1 - 6.7e-67 226.2 0.0 8.5e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sdh_cyt PF01127.22 EFE43044.1 - 0.12 12.4 0.2 0.24 11.4 0.2 1.4 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit FAD_binding_4 PF01565.23 EFE43045.1 - 7.1e-32 110.0 8.4 2.8e-31 108.1 8.1 1.9 2 0 0 2 2 2 1 FAD binding domain Bac_luciferase PF00296.20 EFE43045.1 - 0.06 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Luciferase-like monooxygenase BBE PF08031.12 EFE43045.1 - 0.095 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Berberine and berberine like FAD_binding_4 PF01565.23 EFE43046.1 - 1.4e-20 73.4 1.0 2.4e-20 72.7 1.0 1.4 1 0 0 1 1 1 1 FAD binding domain DRMBL PF07522.14 EFE43047.1 - 2.4e-33 114.6 0.0 4.8e-33 113.6 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EFE43047.1 - 1.1e-05 25.0 0.0 4.4e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFE43047.1 - 0.033 14.2 0.2 0.066 13.2 0.2 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Methyltransf_11 PF08241.12 EFE43048.1 - 5.7e-07 30.1 0.0 1.2e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE43048.1 - 0.059 14.1 0.0 0.17 12.6 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain zf-BED PF02892.15 EFE43049.1 - 0.001 19.0 5.5 0.31 11.1 0.3 2.6 2 0 0 2 2 2 2 BED zinc finger SH3BGR PF04908.15 EFE43050.1 - 0.0002 21.4 0.7 0.0033 17.6 0.0 2.8 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EFE43050.1 - 0.16 12.2 0.3 0.49 10.7 0.0 1.9 2 0 0 2 2 2 0 Glutaredoxin Hamartin PF04388.12 EFE43050.1 - 6.1 5.4 16.1 7.1 5.2 16.1 1.0 1 0 0 1 1 1 0 Hamartin protein Pkinase PF00069.25 EFE43051.1 - 9e-24 84.2 0.0 1.4e-23 83.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43051.1 - 2.3e-07 30.4 0.0 3.2e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE43051.1 - 0.0057 15.5 0.1 0.0092 14.8 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFE43051.1 - 0.014 15.4 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFE43051.1 - 0.19 11.0 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribul_P_3_epim PF00834.19 EFE43052.1 - 1.4e-55 187.8 0.1 1.6e-53 181.1 0.1 2.9 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 EFE43052.1 - 0.099 11.9 0.5 0.14 11.4 0.5 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG zf-C2H2_4 PF13894.6 EFE43053.1 - 0.96 10.5 13.9 0.42 11.6 0.4 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE43053.1 - 1.3 9.6 14.8 4.7 7.9 0.3 4.4 4 0 0 4 4 4 0 Zinc finger, C2H2 type ABC2_membrane PF01061.24 EFE43054.1 - 8.8e-86 286.7 59.9 2.1e-44 151.5 19.2 3.1 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EFE43054.1 - 2.1e-36 125.5 0.0 7.8e-17 62.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFE43054.1 - 1.6e-33 114.4 11.3 4.7e-32 109.8 0.1 3.6 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EFE43054.1 - 2.5e-19 69.7 0.0 5.5e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EFE43054.1 - 1.1e-07 31.4 46.6 0.00062 19.0 18.8 2.8 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 EFE43054.1 - 3.1e-07 30.9 0.0 0.0018 18.7 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFE43054.1 - 4e-06 26.8 0.1 0.0011 18.8 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EFE43054.1 - 1.6e-05 24.5 0.1 0.00011 21.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFE43054.1 - 2.1e-05 24.7 0.1 0.0012 19.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFE43054.1 - 0.00013 22.5 0.1 0.013 16.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFE43054.1 - 0.00098 18.8 2.4 0.046 13.5 0.1 2.8 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFE43054.1 - 0.0021 17.9 0.0 2.3 7.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFE43054.1 - 0.0034 17.7 0.4 1.7 8.9 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFE43054.1 - 0.015 15.0 0.4 2.2 8.0 0.4 2.5 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EFE43054.1 - 0.016 14.8 1.2 0.3 10.6 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 EFE43054.1 - 0.027 14.5 0.2 9.4 6.4 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase SMC_N PF02463.19 EFE43054.1 - 0.03 13.7 0.0 2.2 7.7 0.0 3.0 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 EFE43054.1 - 0.089 13.0 0.1 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EFE43054.1 - 0.1 12.5 2.1 4.2 7.3 0.2 2.9 3 0 0 3 3 3 0 NACHT domain Viral_helicase1 PF01443.18 EFE43054.1 - 0.11 12.2 0.0 4.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MS_channel PF00924.18 EFE43055.1 - 1.8e-24 86.5 2.7 3.9e-24 85.3 2.7 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_5 PF13202.6 EFE43055.1 - 1.2e-05 24.6 0.1 3e-05 23.3 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 EFE43055.1 - 9.9e-05 21.6 0.3 0.00022 20.5 0.3 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EFE43055.1 - 0.00029 20.5 0.1 0.00091 19.0 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EFE43055.1 - 0.0049 17.3 0.5 0.012 16.0 0.5 1.6 1 0 0 1 1 1 1 EF-hand domain pair Scramblase PF03803.15 EFE43055.1 - 0.11 11.8 0.0 0.25 10.6 0.0 1.5 1 0 0 1 1 1 0 Scramblase Ferlin_C PF16165.5 EFE43055.1 - 0.19 11.6 0.0 0.19 11.6 0.0 2.3 3 0 0 3 3 3 0 Ferlin C-terminus DUF4724 PF15852.5 EFE43056.1 - 0.12 12.9 1.2 0.14 12.6 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4724) Tubulin PF00091.25 EFE43057.1 - 1.2e-60 205.1 0.0 1.8e-60 204.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFE43057.1 - 2.7e-44 150.4 0.0 4.6e-44 149.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFE43057.1 - 0.00051 19.8 0.0 0.00099 18.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain TauD PF02668.16 EFE43058.1 - 4.7e-43 147.9 0.0 6.4e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EFE43058.1 - 1.9e-05 25.2 0.0 4.7e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 EFE43058.1 - 0.0071 15.5 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 CsiD Glutaredoxin PF00462.24 EFE43059.1 - 1.4e-18 66.8 0.0 1.3e-16 60.6 0.0 2.5 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 EFE43059.1 - 4.2e-12 46.0 0.0 1.1e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFE43059.1 - 0.00056 20.2 0.0 0.074 13.4 0.0 2.4 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EFE43059.1 - 0.0043 17.5 0.0 0.049 14.1 0.0 2.4 2 1 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EFE43059.1 - 0.02 14.2 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family OPT PF03169.15 EFE43060.1 - 7.3e-169 563.3 51.1 1e-168 562.9 51.1 1.2 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4191 PF13829.6 EFE43060.1 - 0.086 12.2 1.3 0.33 10.3 1.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) SlyX PF04102.12 EFE43062.1 - 0.036 14.7 0.1 5.3 7.7 0.1 2.9 2 0 0 2 2 2 0 SlyX Beta_elim_lyase PF01212.21 EFE43063.1 - 6.3e-62 209.5 0.0 7.6e-62 209.2 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase CN_hydrolase PF00795.22 EFE43064.1 - 3.2e-44 151.2 0.1 4.1e-44 150.9 0.1 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Pkinase PF00069.25 EFE43065.1 - 1.2e-49 169.0 0.0 5.2e-40 137.5 0.0 2.6 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43065.1 - 5.1e-19 68.6 0.0 1.5e-15 57.2 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase FHA PF00498.26 EFE43065.1 - 5.8e-09 36.2 0.4 5.3e-08 33.1 0.2 2.4 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EFE43065.1 - 0.00036 20.8 0.0 0.00094 19.5 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 EFE43065.1 - 0.025 13.9 0.0 0.082 12.2 0.0 1.8 1 1 0 1 1 1 0 Kinase-like APH PF01636.23 EFE43065.1 - 0.09 12.7 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family TFR_dimer PF04253.15 EFE43066.1 - 4.1e-24 85.0 0.0 6.4e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EFE43066.1 - 8.6e-22 77.8 0.0 1.5e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EFE43066.1 - 3.1e-10 39.9 1.0 2.2e-09 37.2 0.1 2.7 3 0 0 3 3 3 1 PA domain Peptidase_M20 PF01546.28 EFE43066.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Glyco_transf_34 PF05637.12 EFE43067.1 - 5.3e-63 212.9 0.0 8e-63 212.3 0.0 1.3 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family GPR15L PF15854.5 EFE43067.1 - 0.37 11.1 1.8 0.98 9.7 1.8 1.7 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 NDUFB10 PF10249.9 EFE43068.1 - 0.034 14.6 0.0 0.037 14.5 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 BRO1 PF03097.18 EFE43069.1 - 2.9e-13 49.4 0.2 6.7e-13 48.2 0.2 1.6 1 1 0 1 1 1 1 BRO1-like domain TAFII55_N PF04658.13 EFE43070.1 - 9.2e-53 178.2 0.5 1.2e-51 174.6 0.0 2.3 2 0 0 2 2 2 1 TAFII55 protein conserved region NinE PF05322.11 EFE43070.1 - 0.058 13.3 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 NINE Protein Bromo_TP PF07524.13 EFE43071.1 - 7e-10 38.8 0.0 1.2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EFE43071.1 - 0.025 14.7 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit LysM PF01476.20 EFE43072.1 - 6.6e-08 32.5 0.0 7.3e-05 22.7 0.0 3.9 5 0 0 5 5 5 1 LysM domain DUF1153 PF06627.11 EFE43072.1 - 0.033 14.3 0.0 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1153) Ank_2 PF12796.7 EFE43074.1 - 7.9e-35 119.3 0.0 2e-11 44.3 0.0 5.2 2 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE43074.1 - 2.5e-27 94.9 2.2 7.5e-06 26.4 0.0 5.8 4 2 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE43074.1 - 3.3e-24 82.3 2.2 0.035 14.6 0.0 9.7 10 0 0 10 10 10 6 Ankyrin repeat Ank PF00023.30 EFE43074.1 - 2.6e-16 59.2 6.2 0.21 12.1 0.1 8.3 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 EFE43074.1 - 3.3e-15 55.9 2.9 0.0013 19.0 0.0 8.5 5 3 4 9 9 9 3 Ankyrin repeats (many copies) SipA PF09052.10 EFE43074.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 SipA N-terminal domain FAD_binding_7 PF03441.14 EFE43076.1 - 1.4e-72 243.4 0.1 4.8e-72 241.7 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EFE43076.1 - 9.8e-42 142.7 0.1 1.7e-41 142.0 0.1 1.4 1 0 0 1 1 1 1 DNA photolyase Aldo_ket_red PF00248.21 EFE43077.1 - 2.1e-52 178.1 0.0 3.2e-52 177.6 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Peptidase_M14 PF00246.24 EFE43078.1 - 2.5e-14 53.8 0.0 3.8e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 EFE43078.1 - 0.0057 15.8 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.8 EFE43078.1 - 0.025 14.0 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Peptidase_M36 PF02128.15 EFE43079.1 - 6.5e-155 515.8 1.9 8.2e-155 515.5 1.9 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EFE43079.1 - 2.4e-17 62.5 3.1 5.3e-17 61.4 3.1 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif adh_short PF00106.25 EFE43080.1 - 2.1e-10 40.4 0.0 3.5e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE43080.1 - 2.9e-07 30.6 0.0 4.7e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EFE43080.1 - 2.2e-05 24.1 0.0 3.5e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase APH PF01636.23 EFE43081.1 - 9.8e-08 32.2 0.0 1.4e-06 28.5 0.0 2.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Hydrolase_3 PF08282.12 EFE43082.1 - 3.3e-10 40.1 0.0 2.4e-07 30.8 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase PMM PF03332.13 EFE43082.1 - 1.4e-09 38.0 0.0 1.8e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase S6PP PF05116.13 EFE43082.1 - 0.00023 20.8 0.0 0.026 14.1 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EFE43082.1 - 0.0091 16.3 0.2 0.32 11.2 0.1 2.3 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase MS_channel PF00924.18 EFE43082.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel F_bP_aldolase PF01116.20 EFE43083.1 - 9.8e-91 304.1 0.0 1.1e-90 303.9 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II UCH PF00443.29 EFE43085.1 - 2.8e-36 125.3 0.6 2.6e-31 109.1 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE43085.1 - 1.7e-11 44.3 0.4 1.8e-10 40.9 0.4 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zinc_ribbon_4 PF13717.6 EFE43085.1 - 0.38 10.7 7.2 1.9 8.4 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain CDC27 PF09507.10 EFE43086.1 - 0.54 9.6 41.1 0.78 9.1 41.1 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 LAP1C PF05609.12 EFE43086.1 - 1.2 8.1 25.9 1.5 7.8 25.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 EFE43086.1 - 2.6 6.2 22.3 3.2 6.0 22.3 1.3 1 0 0 1 1 1 0 CDC45-like protein MMR1 PF08505.10 EFE43086.1 - 5.3 7.3 23.7 7.3 6.8 23.7 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein ISK_Channel PF02060.15 EFE43087.1 - 0.96 9.2 2.3 1.1 9.0 2.1 1.2 1 1 0 1 1 1 0 Slow voltage-gated potassium channel ATP-grasp_3 PF02655.14 EFE43089.1 - 3.2e-08 33.8 0.0 5.4e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 EFE43089.1 - 5.7e-06 26.0 0.0 1.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain fn3_5 PF06280.12 EFE43089.1 - 0.19 12.4 0.0 0.36 11.5 0.0 1.4 1 0 0 1 1 1 0 Fn3-like domain PRCC PF10253.9 EFE43090.1 - 6e-26 92.6 22.6 6e-26 92.6 22.6 3.6 1 1 1 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting HNH_2 PF13391.6 EFE43090.1 - 3.3e-14 52.8 0.1 6.8e-14 51.8 0.1 1.6 1 0 0 1 1 1 1 HNH endonuclease YugN PF08868.10 EFE43090.1 - 0.052 13.5 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 YugN-like family BRF1 PF07741.13 EFE43091.1 - 0.15 12.4 20.2 0.68 10.3 12.2 3.1 2 1 0 2 2 2 0 Brf1-like TBP-binding domain Glyco_trans_1_2 PF13524.6 EFE43091.1 - 0.92 9.9 4.3 3.1 8.2 4.3 1.9 1 0 0 1 1 1 0 Glycosyl transferases group 1 Lectin_leg-like PF03388.13 EFE43092.1 - 4.8e-47 160.2 0.0 6.5e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.19 EFE43092.1 - 0.026 14.1 0.0 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 Legume lectin domain Pkinase PF00069.25 EFE43093.1 - 2.5e-72 243.4 0.0 3.9e-72 242.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43093.1 - 1.1e-36 126.5 0.0 1.6e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE43093.1 - 2.6e-07 30.2 0.0 4e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DUF5540 PF17694.1 EFE43093.1 - 0.029 14.9 0.3 0.076 13.5 0.3 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5540) Haspin_kinase PF12330.8 EFE43093.1 - 0.047 12.6 0.6 0.078 11.9 0.6 1.3 1 1 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 EFE43093.1 - 0.057 12.5 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 CRIM PF16978.5 EFE43094.1 - 7.3e-43 146.1 0.0 1.2e-42 145.4 0.0 1.3 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EFE43094.1 - 1.3e-26 93.0 0.5 2.5e-26 92.1 0.5 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 EFE43094.1 - 0.0073 16.5 0.1 0.014 15.6 0.1 1.4 1 0 0 1 1 1 1 TUG ubiquitin-like domain DUF4337 PF14235.6 EFE43095.1 - 0.071 13.2 0.7 0.09 12.9 0.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) MCU PF04678.13 EFE43095.1 - 0.092 12.8 1.2 0.12 12.5 1.2 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Peptidase_M28 PF04389.17 EFE43096.1 - 7.1e-33 114.0 0.2 1.5e-32 112.9 0.2 1.6 1 0 0 1 1 1 1 Peptidase family M28 Mito_carr PF00153.27 EFE43096.1 - 1.5e-11 44.1 0.3 1e-05 25.3 0.0 2.8 3 0 0 3 3 3 2 Mitochondrial carrier protein Peptidase_M20 PF01546.28 EFE43096.1 - 0.0018 18.0 1.1 0.034 13.9 1.2 2.5 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 CENP-T_C PF15511.6 EFE43097.1 - 7.7e-09 35.6 0.1 9.5e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EFE43097.1 - 2.4e-05 24.7 0.2 2.8e-05 24.5 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EFE43097.1 - 8.7e-05 22.6 0.1 0.00012 22.1 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFE43097.1 - 0.00022 21.4 0.1 0.00044 20.5 0.1 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EFE43097.1 - 0.00026 21.3 0.1 0.00035 20.9 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EFE43097.1 - 0.0047 17.0 0.0 0.0056 16.7 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFE43097.1 - 0.013 15.5 0.0 0.02 14.9 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.13 EFE43097.1 - 0.063 13.8 0.1 0.12 12.9 0.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A HIGH_NTase1_ass PF16581.5 EFE43097.1 - 0.13 12.2 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region CBM_21 PF03370.13 EFE43098.1 - 2.1e-30 105.2 0.0 4.1e-30 104.3 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EFE43098.1 - 9.7e-09 35.7 1.4 1.9e-08 34.7 0.5 2.0 2 0 0 2 2 2 1 Starch/carbohydrate-binding module (family 53) Connexin PF00029.19 EFE43099.1 - 0.0028 17.4 0.0 0.0042 16.9 0.0 1.2 1 0 0 1 1 1 1 Connexin Orf78 PF06024.12 EFE43099.1 - 0.025 14.9 2.5 0.064 13.6 2.5 1.7 1 1 0 1 1 1 0 Orf78 (ac78) DUF3464 PF11947.8 EFE43099.1 - 0.028 14.2 2.9 0.061 13.1 2.9 1.5 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 DUF3043 PF11241.8 EFE43099.1 - 0.066 13.2 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) NARP1 PF12569.8 EFE43099.1 - 2.5 6.9 10.1 3 6.6 10.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF5592 PF17332.2 EFE43100.1 - 3.5 8.3 4.6 0.68 10.5 0.1 2.0 2 1 0 2 2 2 0 Family of unknown function (DUF5592) APH PF01636.23 EFE43102.1 - 2.5e-14 53.8 0.0 4.8e-14 52.9 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE43102.1 - 0.00049 19.7 0.0 0.00072 19.2 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EFE43102.1 - 0.011 14.7 0.0 0.016 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) EcKinase PF02958.20 EFE43102.1 - 0.13 11.5 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase HMGL-like PF00682.19 EFE43103.1 - 5.7e-73 245.7 0.0 8.1e-73 245.2 0.0 1.2 1 0 0 1 1 1 1 HMGL-like CENP-B_dimeris PF09026.10 EFE43105.1 - 0.016 15.5 2.3 0.021 15.2 2.3 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PTH2 PF01981.16 EFE43105.1 - 0.057 13.7 0.1 0.086 13.1 0.1 1.2 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase PTH2 Sec23_trunk PF04811.15 EFE43105.1 - 0.086 12.4 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain NOA36 PF06524.12 EFE43105.1 - 0.14 11.5 2.6 0.17 11.2 2.6 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EFE43105.1 - 3.8 5.5 4.5 4.2 5.3 4.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi SART-1 PF03343.13 EFE43106.1 - 4.6e-185 616.8 59.6 5.3e-185 616.6 59.6 1.0 1 0 0 1 1 1 1 SART-1 family FeoC PF09012.10 EFE43106.1 - 0.092 12.8 1.5 9.9 6.3 0.0 2.9 3 0 0 3 3 3 0 FeoC like transcriptional regulator WD40 PF00400.32 EFE43107.1 - 1.7e-16 60.3 2.9 0.00039 21.2 0.0 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE43107.1 - 0.0017 18.6 0.0 3 8.2 0.0 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EFE43107.1 - 0.0018 17.1 0.0 0.63 8.7 0.0 2.2 2 0 0 2 2 2 2 Nup133 N terminal like SR-25 PF10500.9 EFE43108.1 - 0.00013 21.6 8.3 0.00013 21.6 8.3 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein MAJIN PF15077.6 EFE43108.1 - 0.023 14.5 4.9 0.079 12.7 0.1 2.1 2 0 0 2 2 2 0 Membrane-anchored junction protein PMD PF10536.9 EFE43108.1 - 0.077 12.1 1.3 0.11 11.6 1.3 1.2 1 0 0 1 1 1 0 Plant mobile domain Paramyxo_C PF01692.18 EFE43108.1 - 0.12 11.7 4.4 0.27 10.6 4.5 1.5 1 1 0 1 1 1 0 Paramyxovirus non-structural protein C RNA_polI_A34 PF08208.11 EFE43108.1 - 1.4 9.0 23.0 0.18 11.9 4.3 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 EOS1 PF12326.8 EFE43108.1 - 1.6 8.6 4.3 17 5.3 3.0 2.2 2 0 0 2 2 2 0 N-glycosylation protein Porph_ging PF09697.10 EFE43108.1 - 2.2 8.9 9.4 0.16 12.5 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) Connexin PF00029.19 EFE43108.1 - 3.9 7.2 6.3 3.3 7.4 0.6 2.1 2 0 0 2 2 2 0 Connexin PPL5 PF18168.1 EFE43108.1 - 7.7 5.7 9.8 6.3 6.0 1.9 2.1 2 0 0 2 2 2 0 Prim-pol family 5 Jak1_Phl PF17887.1 EFE43108.1 - 9.1 6.2 15.1 0.66 9.9 2.9 2.4 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain ELL PF10390.9 EFE43109.1 - 0.00037 20.1 0.0 0.00037 20.1 0.0 2.5 2 1 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.13 EFE43109.1 - 0.27 12.0 4.2 0.25 12.1 1.9 2.1 2 0 0 2 2 2 0 Occludin homology domain APH PF01636.23 EFE43111.1 - 4.8e-11 43.0 1.7 2.2e-09 37.6 1.7 2.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF155 PF02582.14 EFE43112.1 - 4.3e-53 180.0 0.0 9.5e-53 178.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Mpp10 PF04006.12 EFE43112.1 - 1.9 6.8 25.0 0.64 8.4 5.6 2.0 2 0 0 2 2 2 0 Mpp10 protein CDC45 PF02724.14 EFE43112.1 - 3.2 5.9 27.5 0.26 9.5 6.4 2.1 2 0 0 2 2 2 0 CDC45-like protein FYDLN_acid PF09538.10 EFE43112.1 - 3.9 8.2 17.8 3.7 8.3 4.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Aldedh PF00171.22 EFE43113.1 - 2e-144 481.6 0.1 2.4e-144 481.3 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EFE43113.1 - 0.13 11.7 0.3 0.27 10.6 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Pkinase PF00069.25 EFE43114.1 - 2.3e-23 82.9 0.0 3.1e-23 82.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43114.1 - 5.5e-13 48.8 0.0 7.5e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.12 EFE43115.1 - 4.4e-33 113.0 48.8 4.5e-06 27.2 1.5 12.9 13 1 1 14 14 14 8 Sel1 repeat Mei5 PF10376.9 EFE43116.1 - 0.0047 16.8 7.0 0.0094 15.8 0.9 2.2 2 0 0 2 2 2 2 Double-strand recombination repair protein Drc1-Sld2 PF11719.8 EFE43116.1 - 0.31 10.5 9.7 0.38 10.3 9.7 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein SDA1 PF05285.12 EFE43116.1 - 1.1 8.6 17.1 1.5 8.2 17.1 1.1 1 0 0 1 1 1 0 SDA1 Dus PF01207.17 EFE43118.1 - 5.9e-42 143.8 0.0 1.3e-29 103.3 0.0 2.6 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EFE43118.1 - 0.00093 19.1 2.8 0.039 13.9 0.4 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFE43118.1 - 0.0041 17.1 7.2 0.099 12.7 1.8 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EFE43118.1 - 0.0068 16.2 1.0 0.0068 16.2 1.0 3.2 3 0 0 3 3 3 1 CCCH-type zinc finger Kelch_1 PF01344.25 EFE43119.1 - 3.3e-17 61.8 0.5 6.7e-06 25.6 0.1 3.8 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 EFE43119.1 - 1.6e-15 56.7 0.6 3.6e-05 23.9 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EFE43119.1 - 6.2e-15 54.5 0.2 4.1e-07 29.7 0.1 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EFE43119.1 - 5.3e-14 52.0 3.7 3.2e-05 23.8 0.0 3.8 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFE43119.1 - 1e-12 47.7 0.0 1e-05 25.4 0.0 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 EFE43119.1 - 3.8e-10 39.8 8.5 1.7e-07 31.4 0.0 5.2 5 0 0 5 5 5 2 Galactose oxidase, central domain BTB PF00651.31 EFE43119.1 - 4.4e-08 33.3 0.0 8.9e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain APH PF01636.23 EFE43120.1 - 1.2e-11 45.0 0.0 2.6e-11 43.9 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE43120.1 - 8e-07 28.8 0.3 1.8e-06 27.7 0.3 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EFE43120.1 - 0.00036 20.0 0.1 0.13 11.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain EcKinase PF02958.20 EFE43120.1 - 0.0012 18.2 0.1 0.0017 17.7 0.1 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EFE43120.1 - 0.0096 14.8 0.0 0.013 14.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) ANAPC4_WD40 PF12894.7 EFE43121.1 - 7.6e-16 58.2 2.7 8.7e-06 26.0 0.1 4.3 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFE43121.1 - 1.7e-15 57.1 15.5 0.00048 20.9 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EFE43121.1 - 1.5e-05 24.1 0.0 0.00093 18.2 0.0 3.0 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFE43121.1 - 0.00047 20.1 0.3 0.026 14.4 0.1 2.4 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A HNH_2 PF13391.6 EFE43122.1 - 0.03 14.5 0.0 0.07 13.3 0.0 1.6 1 0 0 1 1 1 0 HNH endonuclease TFIIA PF03153.13 EFE43123.1 - 1.6e-61 209.6 32.9 6.3e-59 201.0 26.7 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF2563 PF10817.8 EFE43123.1 - 0.069 13.8 0.2 0.14 12.8 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2563) zf-C2H2 PF00096.26 EFE43125.1 - 2.9e-06 27.4 6.7 0.05 14.1 0.8 4.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 EFE43125.1 - 9.8e-05 22.6 1.0 0.045 13.9 0.0 2.5 2 0 0 2 2 2 2 Aberrant zinc-finger zf-H2C2_2 PF13465.6 EFE43125.1 - 0.026 14.9 0.5 0.026 14.9 0.5 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE43125.1 - 0.03 15.1 0.6 0.03 15.1 0.6 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger DUF4719 PF15843.5 EFE43125.1 - 0.11 12.6 0.0 0.11 12.6 0.0 2.8 3 1 1 4 4 4 0 Domain of unknown function (DUF4719) DUF4661 PF15576.6 EFE43126.1 - 0.53 10.2 5.7 0.6 10.0 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) GRP PF07172.11 EFE43126.1 - 9.9 6.9 13.8 2.1 9.1 8.6 2.1 1 1 1 2 2 2 0 Glycine rich protein family Bap31 PF05529.12 EFE43127.1 - 1.3e-44 151.3 5.5 2.3e-44 150.6 5.5 1.3 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EFE43127.1 - 2.7e-15 56.1 5.2 4.4e-15 55.4 5.2 1.4 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain DUF4349 PF14257.6 EFE43127.1 - 0.025 14.1 0.0 0.2 11.1 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) DivIC PF04977.15 EFE43127.1 - 0.068 12.9 2.0 0.13 12.1 0.4 2.3 2 0 0 2 2 2 0 Septum formation initiator Atg14 PF10186.9 EFE43127.1 - 0.14 11.3 1.5 0.19 10.8 1.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MMM1 PF10296.9 EFE43128.1 - 2.2e-07 30.3 0.0 4.7e-07 29.2 0.0 1.4 2 0 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 Pkinase PF00069.25 EFE43130.1 - 1.5e-63 214.7 0.0 2.4e-63 214.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43130.1 - 1.1e-34 119.9 0.0 2.7e-29 102.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFE43130.1 - 2.8e-06 26.9 0.1 0.00065 19.1 0.1 2.2 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EFE43130.1 - 0.00041 20.3 0.5 0.0016 18.4 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFE43130.1 - 0.004 16.8 0.0 0.0083 15.7 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 EFE43130.1 - 0.017 14.1 0.2 0.028 13.4 0.2 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EFE43130.1 - 0.035 13.4 0.0 0.063 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TSA PF03249.13 EFE43130.1 - 5.3 5.7 6.9 0.87 8.3 1.0 2.1 2 0 0 2 2 2 0 Type specific antigen Senescence PF06911.12 EFE43131.1 - 2.4e-54 184.4 1.6 4.1e-54 183.7 1.6 1.4 1 0 0 1 1 1 1 Senescence-associated protein Acyl-CoA_dh_1 PF00441.24 EFE43132.1 - 4.7e-35 121.0 4.5 7.1e-31 107.5 1.9 2.3 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFE43132.1 - 4.9e-30 104.5 0.8 1.3e-29 103.2 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFE43132.1 - 2.2e-24 85.5 0.0 9.3e-24 83.5 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFE43132.1 - 2.2e-11 44.2 0.3 2.2e-11 44.2 0.3 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain AgrD PF05931.11 EFE43132.1 - 0.0061 16.6 0.0 0.021 14.8 0.0 1.9 1 0 0 1 1 1 1 Staphylococcal AgrD protein HpaB_N PF11794.8 EFE43132.1 - 0.017 14.8 0.0 0.046 13.4 0.0 1.7 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal MFS_1 PF07690.16 EFE43133.1 - 3.8e-25 88.6 35.2 2.6e-18 66.1 11.5 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFE43133.1 - 0.00036 19.5 0.8 0.00036 19.5 0.8 3.0 2 1 1 3 3 3 1 MFS_1 like family Pkinase PF00069.25 EFE43134.1 - 2.2e-27 96.1 0.0 3.1e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43134.1 - 3.5e-14 52.7 0.0 5.7e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE43134.1 - 2.7e-07 29.7 0.1 4e-07 29.2 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase YMF19 PF02326.15 EFE43135.1 - 0.035 14.9 2.3 0.035 14.9 2.3 1.6 2 0 0 2 2 2 0 Plant ATP synthase F0 Rtt106 PF08512.12 EFE43136.1 - 9.8e-31 106.0 0.0 1.9e-30 105.1 0.0 1.5 1 0 0 1 1 1 1 Histone chaperone Rttp106-like PH_18 PF18469.1 EFE43136.1 - 0.011 15.8 0.0 0.07 13.1 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain PPP4R2 PF09184.11 EFE43136.1 - 9.9 5.6 10.9 16 5.0 10.9 1.3 1 0 0 1 1 1 0 PPP4R2 KOW PF00467.29 EFE43137.1 - 2.1e-06 27.4 0.5 4.3e-06 26.5 0.5 1.5 1 0 0 1 1 1 1 KOW motif SH3_13 PF18335.1 EFE43137.1 - 0.1 12.4 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain Ras PF00071.22 EFE43138.1 - 3.2e-38 130.9 0.0 4.5e-21 75.1 0.0 2.2 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EFE43138.1 - 6.1e-11 42.6 0.0 4.2e-10 39.9 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE43138.1 - 0.01 15.3 0.0 0.026 14.0 0.0 1.7 1 1 0 1 1 1 0 ADP-ribosylation factor family baeRF_family3 PF18845.1 EFE43138.1 - 0.074 13.3 0.0 0.27 11.5 0.0 1.8 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 MGC-24 PF05283.11 EFE43139.1 - 5.2e-05 23.7 2.4 9.1e-05 22.9 0.1 2.1 2 0 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Podoplanin PF05808.11 EFE43139.1 - 0.00081 19.5 0.1 0.0019 18.3 0.0 1.6 2 0 0 2 2 2 1 Podoplanin VSP PF03302.13 EFE43139.1 - 0.16 10.8 0.4 0.26 10.1 0.4 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein SKG6 PF08693.10 EFE43139.1 - 0.2 11.1 2.8 0.5 9.8 2.8 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Syndecan PF01034.20 EFE43139.1 - 0.2 11.6 1.0 0.35 10.8 1.0 1.3 1 0 0 1 1 1 0 Syndecan domain Aldedh PF00171.22 EFE43140.1 - 1.5e-143 478.7 0.0 1.9e-143 478.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1712 PF08217.11 EFE43141.1 - 1.3e-19 70.1 0.0 2.8e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) Formyl_trans_C PF02911.18 EFE43142.1 - 0.14 12.4 0.1 0.32 11.3 0.1 1.6 1 1 0 1 1 1 0 Formyl transferase, C-terminal domain adh_short_C2 PF13561.6 EFE43143.1 - 5e-41 140.8 0.1 5.6e-41 140.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE43143.1 - 1.1e-34 119.6 0.0 1.4e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE43143.1 - 8e-06 25.9 0.2 1e-05 25.5 0.2 1.2 1 0 0 1 1 1 1 KR domain EMP24_GP25L PF01105.24 EFE43144.1 - 3.1e-40 138.1 0.0 3.4e-40 137.9 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD HXXSHH PF07586.11 EFE43144.1 - 0.048 13.2 1.5 0.063 12.9 1.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1552) SdrD_B PF17210.3 EFE43144.1 - 0.12 12.7 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 SdrD B-like domain PspB PF06667.12 EFE43144.1 - 0.15 12.1 0.6 0.28 11.2 0.6 1.5 1 0 0 1 1 1 0 Phage shock protein B TFIID-18kDa PF02269.16 EFE43145.1 - 0.1 12.6 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit RGS PF00615.19 EFE43146.1 - 6.8e-11 42.5 0.0 1.2e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain S36_mt PF10937.8 EFE43150.1 - 2.3e-42 145.2 0.5 2.7e-42 145.0 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial Med18 PF09637.10 EFE43151.1 - 8.2e-43 147.0 0.0 9.3e-43 146.9 0.0 1.0 1 0 0 1 1 1 1 Med18 protein HGTP_anticodon PF03129.20 EFE43152.1 - 1.1e-18 67.2 3.0 1.1e-18 67.2 0.0 2.6 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EFE43152.1 - 3.1e-08 33.8 0.0 2.4e-07 30.9 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Brix PF04427.18 EFE43153.1 - 9e-23 81.4 0.0 1.3e-22 80.8 0.0 1.3 1 0 0 1 1 1 1 Brix domain BUD22 PF09073.10 EFE43153.1 - 0.46 9.8 19.2 0.7 9.2 19.2 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EFE43153.1 - 5.6 5.0 23.1 7.3 4.7 23.1 1.1 1 0 0 1 1 1 0 Nop14-like family SRI PF08236.11 EFE43155.1 - 8.4e-21 73.9 15.2 3.1e-20 72.1 15.2 2.1 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 EFE43155.1 - 4.8e-17 62.9 0.3 4.8e-17 62.9 0.3 3.6 3 1 0 3 3 3 1 SET domain AWS PF17907.1 EFE43155.1 - 1.6e-10 40.9 11.9 1.6e-10 40.9 11.9 2.7 2 0 0 2 2 2 1 AWS domain Med26 PF08711.11 EFE43155.1 - 1.1e-05 25.4 0.2 3.2e-05 23.8 0.2 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain WW PF00397.26 EFE43155.1 - 0.032 14.3 0.3 0.089 12.9 0.3 1.9 1 0 0 1 1 1 0 WW domain PHA_synth_III_E PF09712.10 EFE43155.1 - 0.11 11.5 0.4 0.2 10.7 0.4 1.3 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Pox_H7 PF04787.12 EFE43155.1 - 0.35 11.4 4.8 0.71 10.4 4.8 1.4 1 0 0 1 1 1 0 Late protein H7 Es2 PF09751.9 EFE43159.1 - 1.1e-140 470.2 15.5 1.3e-140 470.0 15.5 1.0 1 0 0 1 1 1 1 Nuclear protein Es2 Anophelin PF10731.9 EFE43159.1 - 0.16 11.8 1.5 0.54 10.1 1.5 1.9 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Mid1 PF12929.7 EFE43160.1 - 2.7e-133 445.3 6.1 7.4e-70 236.3 5.0 2.0 1 1 1 2 2 2 2 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 EFE43160.1 - 0.00051 20.6 3.8 0.061 13.9 0.7 2.3 2 0 0 2 2 2 2 Fz domain CorA PF01544.18 EFE43161.1 - 1.4e-42 146.0 0.0 1.8e-42 145.6 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MFS_1 PF07690.16 EFE43162.1 - 4.2e-05 22.6 25.5 0.016 14.1 26.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2561 PF10812.8 EFE43162.1 - 0.005 16.9 0.0 0.0085 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2561) DUF308 PF03729.13 EFE43162.1 - 0.033 14.5 4.8 0.033 14.5 4.8 2.7 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) BaxI_1 PF12811.7 EFE43162.1 - 0.42 10.1 11.1 0.14 11.7 0.7 2.3 2 0 0 2 2 2 0 Bax inhibitor 1 like RRM_1 PF00076.22 EFE43163.1 - 1.3e-40 137.1 0.4 1.7e-18 66.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EFE43163.1 - 2.9e-26 92.4 0.7 5.4e-24 85.1 0.2 3.0 3 0 0 3 3 3 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 EFE43163.1 - 0.00084 19.2 0.0 1 9.2 0.0 2.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 EFE43163.1 - 0.062 13.4 0.0 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.5 EFE43163.1 - 0.068 13.3 0.0 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 EFE43163.1 - 0.072 13.3 0.1 5.6 7.2 0.1 2.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter ATG16 PF08614.11 EFE43164.1 - 0.031 14.5 4.3 0.051 13.8 4.3 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 EFE43164.1 - 0.14 11.4 2.0 0.22 10.8 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GrpE PF01025.19 EFE43164.1 - 0.47 10.1 5.9 1.7 8.3 0.2 2.6 2 1 1 3 3 3 0 GrpE TRAF_BIRC3_bd PF16673.5 EFE43164.1 - 0.78 9.6 2.6 2.2 8.2 1.6 2.0 1 1 1 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain PKcGMP_CC PF16808.5 EFE43164.1 - 1.9 8.4 7.0 5.2 7.0 1.1 3.3 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Metal_resist PF13801.6 EFE43164.1 - 2.2 8.5 6.4 7 6.9 6.4 1.8 1 0 0 1 1 1 0 Heavy-metal resistance PP2C PF00481.21 EFE43167.1 - 3.6e-32 112.0 0.0 4.1e-26 92.2 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EFE43167.1 - 0.012 15.3 0.2 0.028 14.0 0.0 1.7 2 0 0 2 2 2 0 Protein phosphatase 2C CDP-OH_P_transf PF01066.21 EFE43168.1 - 1.4e-12 48.1 0.4 1.4e-12 48.1 0.4 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Methyltransf_23 PF13489.6 EFE43169.1 - 3.4e-10 40.0 0.0 7.9e-10 38.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE43169.1 - 0.0092 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE43169.1 - 0.038 14.7 0.0 0.4 11.4 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFE43169.1 - 0.054 14.2 0.0 0.15 12.7 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_S9 PF00380.19 EFE43170.1 - 5.6e-35 120.5 0.2 5.6e-35 120.5 0.2 2.1 3 0 0 3 3 3 1 Ribosomal protein S9/S16 EF1G PF00647.19 EFE43171.1 - 1.1e-48 163.7 0.3 1.9e-48 163.0 0.3 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EFE43171.1 - 3.9e-12 46.2 0.0 8.5e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE43171.1 - 1.2e-08 34.8 0.1 3e-08 33.6 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFE43171.1 - 1.9e-05 24.8 0.0 4.6e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ribosomal_60s PF00428.19 EFE43171.1 - 5.7 7.6 12.3 12 6.6 12.3 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein NIF PF03031.18 EFE43172.1 - 5.7e-28 97.6 3.3 3.7e-27 95.0 3.3 2.0 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase RRP36 PF06102.12 EFE43173.1 - 1.2e-43 148.9 37.2 1.2e-43 148.9 37.2 2.6 1 1 1 2 2 2 1 rRNA biogenesis protein RRP36 U3_snoRNA_assoc PF08297.11 EFE43179.1 - 0.029 15.1 5.6 0.034 14.9 5.6 1.2 1 0 0 1 1 1 0 U3 snoRNA associated FGF-BP1 PF06473.12 EFE43179.1 - 0.067 13.0 4.2 0.088 12.6 4.2 1.1 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Pkinase PF00069.25 EFE43180.1 - 1.9e-51 175.0 0.0 2.5e-51 174.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43180.1 - 8.8e-31 107.1 0.0 1.1e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE43180.1 - 0.00037 20.5 0.0 0.0037 17.2 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFE43180.1 - 0.0069 15.7 0.0 0.024 14.0 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EFE43180.1 - 0.028 13.8 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFE43180.1 - 0.15 11.0 0.1 0.31 9.9 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain APG6_N PF17675.1 EFE43182.1 - 0.57 10.7 4.1 0.24 11.9 1.6 1.7 2 0 0 2 2 2 0 Apg6 coiled-coil region FSH1 PF03959.13 EFE43184.1 - 1.2e-66 224.4 0.0 1.7e-66 223.9 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EFE43184.1 - 0.00056 20.6 1.1 0.0011 19.6 1.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EFE43184.1 - 0.042 13.4 0.0 0.5 9.9 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EFE43184.1 - 0.13 11.5 0.0 0.36 10.1 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 PCI PF01399.27 EFE43185.1 - 8.5e-23 80.9 0.2 3e-22 79.1 0.0 2.0 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 EFE43185.1 - 2e-16 59.8 1.9 5.1e-16 58.5 1.9 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain CLTH PF10607.9 EFE43185.1 - 0.019 14.8 0.9 1.9 8.4 0.9 2.8 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain TP_methylase PF00590.20 EFE43186.1 - 5.9e-46 157.1 0.0 1.1e-45 156.3 0.0 1.4 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_C PF14823.6 EFE43186.1 - 1.4e-08 34.2 0.0 7.9e-05 22.2 0.0 2.3 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.6 EFE43186.1 - 0.0023 18.3 0.0 0.0051 17.2 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding DeoC PF01791.9 EFE43187.1 - 1.9e-16 60.4 1.9 2.8e-16 59.9 1.9 1.2 1 0 0 1 1 1 1 DeoC/LacD family aldolase DHO_dh PF01180.21 EFE43187.1 - 8.8e-05 21.9 1.4 0.00013 21.3 1.4 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 EFE43187.1 - 0.018 14.5 0.5 0.034 13.6 0.5 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein FMN_dh PF01070.18 EFE43187.1 - 0.07 12.2 2.4 0.12 11.4 2.4 1.7 1 1 0 1 1 1 0 FMN-dependent dehydrogenase ComA PF02679.15 EFE43187.1 - 0.075 12.5 0.0 0.17 11.3 0.0 1.6 1 1 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) WD40 PF00400.32 EFE43189.1 - 2.1e-09 37.8 6.5 5e-05 24.0 0.1 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE43189.1 - 0.021 15.1 0.0 11 6.4 0.0 3.9 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain PPP4R2 PF09184.11 EFE43189.1 - 0.046 13.3 3.6 0.064 12.8 3.6 1.2 1 0 0 1 1 1 0 PPP4R2 Gryzun-like PF12742.7 EFE43189.1 - 0.096 12.7 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking CorA PF01544.18 EFE43189.1 - 0.35 10.1 2.5 0.58 9.4 2.5 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein LIAS_N PF16881.5 EFE43190.1 - 1.6e-26 92.8 0.0 3.9e-26 91.6 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EFE43190.1 - 2.1e-13 51.0 0.0 3.5e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily HAD PF12710.7 EFE43191.1 - 7.8e-20 72.1 0.1 3.5e-19 69.9 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFE43191.1 - 1.5e-16 61.4 1.5 8.1e-16 58.9 1.5 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFE43191.1 - 1.7e-07 31.3 0.0 1.8e-06 27.9 0.0 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFE43191.1 - 0.00062 19.9 0.0 0.73 9.9 0.0 3.0 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EFE43191.1 - 0.0021 17.5 0.0 0.058 12.8 0.0 2.3 2 0 0 2 2 2 1 Putative Phosphatase DUF347 PF03988.12 EFE43191.1 - 0.031 14.5 0.4 0.083 13.1 0.4 1.7 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) DUF705 PF05152.12 EFE43191.1 - 0.053 13.0 0.1 0.079 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF705) S6PP PF05116.13 EFE43191.1 - 0.16 11.5 0.1 0.46 10.0 0.0 1.7 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase PAPS_reduct PF01507.19 EFE43193.1 - 6.8e-43 146.7 0.0 1.1e-42 146.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family OppC_N PF12911.7 EFE43193.1 - 0.62 10.1 2.7 0.59 10.2 0.2 2.1 1 1 1 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DHHC PF01529.20 EFE43193.1 - 2.1 8.4 6.6 3.8 7.6 6.6 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase ATP-sulfurylase PF01747.17 EFE43194.1 - 2.5e-87 291.8 0.0 3.6e-87 291.3 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 EFE43194.1 - 1.2e-57 194.2 0.0 1.9e-57 193.6 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EFE43194.1 - 5.5e-50 169.1 0.0 9.1e-50 168.4 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain AJAP1_PANP_C PF15298.6 EFE43196.1 - 0.33 11.2 13.3 2 8.6 0.0 2.6 2 0 0 2 2 2 0 AJAP1/PANP C-terminus hEGF PF12661.7 EFE43196.1 - 0.55 10.9 7.6 1.2 9.9 7.6 1.6 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_CA PF07645.15 EFE43196.1 - 1.2 9.4 5.6 2.6 8.3 5.6 1.4 1 0 0 1 1 1 0 Calcium-binding EGF domain EGF PF00008.27 EFE43196.1 - 2.1 8.7 8.3 4.4 7.7 8.3 1.6 1 0 0 1 1 1 0 EGF-like domain Mucin PF01456.17 EFE43196.1 - 2.6 8.0 22.8 0.077 13.0 15.9 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein Sld3_N PF18523.1 EFE43199.1 - 0.012 15.7 1.3 0.015 15.4 1.3 1.2 1 0 0 1 1 1 0 Sld3 N-terminal domain KIND PF16474.5 EFE43199.1 - 0.092 12.6 1.5 0.092 12.6 1.5 1.0 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain Pannexin_like PF12534.8 EFE43200.1 - 0.48 9.5 2.0 0.66 9.0 2.0 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 PMC2NT PF08066.12 EFE43202.1 - 0.0015 19.2 0.1 0.0024 18.5 0.1 1.4 1 0 0 1 1 1 1 PMC2NT (NUC016) domain MRP-S26 PF14943.6 EFE43202.1 - 0.027 14.4 1.0 0.045 13.7 1.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 SET PF00856.28 EFE43204.1 - 3.6e-13 50.2 0.2 3.6e-13 50.2 0.2 3.2 3 1 0 3 3 3 1 SET domain AWS PF17907.1 EFE43204.1 - 2.6e-07 30.5 10.0 2.6e-07 30.5 10.0 2.2 3 0 0 3 3 3 1 AWS domain Lipocalin_9 PF17186.4 EFE43204.1 - 4.4 7.6 6.3 22 5.3 0.3 2.8 2 1 0 2 2 2 0 Lipocalin-like domain DHHC PF01529.20 EFE43205.1 - 3.3e-34 117.9 7.6 3.3e-34 117.9 7.6 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase PMT PF02366.18 EFE43207.1 - 3.3e-79 265.9 14.9 3.3e-79 265.9 14.9 1.9 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EFE43207.1 - 6.8e-65 218.4 16.0 6.8e-65 218.4 16.0 2.1 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EFE43207.1 - 2.7e-46 157.8 0.0 5.5e-46 156.8 0.0 1.5 1 0 0 1 1 1 1 MIR domain Arteri_Gl PF00951.18 EFE43207.1 - 0.0022 17.8 1.6 0.0046 16.8 1.6 1.4 1 0 0 1 1 1 1 Arterivirus GL envelope glycoprotein Androgen_recep PF02166.16 EFE43207.1 - 3.4 6.4 13.1 5 5.8 13.1 1.2 1 0 0 1 1 1 0 Androgen receptor PRP21_like_P PF12230.8 EFE43208.1 - 1.1e-55 188.8 8.1 2.5e-30 106.0 2.1 2.3 2 0 0 2 2 2 2 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EFE43208.1 - 5.4e-27 93.5 1.3 1.3e-16 60.4 0.5 2.4 2 0 0 2 2 2 2 Surp module zf_UBZ PF18439.1 EFE43208.1 - 0.023 14.3 0.6 0.057 13.0 0.6 1.6 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-Dof PF02701.15 EFE43208.1 - 0.41 10.8 1.3 10 6.4 0.0 2.5 2 0 0 2 2 2 0 Dof domain, zinc finger Sec2p PF06428.11 EFE43209.1 - 1.9e-30 104.7 17.3 1.9e-30 104.7 17.3 2.3 3 0 0 3 3 3 1 GDP/GTP exchange factor Sec2p Tht1 PF04163.12 EFE43209.1 - 0.14 10.9 2.4 0.2 10.4 2.4 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein DUF3584 PF12128.8 EFE43209.1 - 0.15 9.6 17.3 0.21 9.1 17.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HrpB7 PF09486.10 EFE43209.1 - 0.45 10.9 15.3 1 9.8 15.3 1.5 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Spc7 PF08317.11 EFE43209.1 - 1.2 8.0 16.7 1.9 7.3 16.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 EFE43209.1 - 2.3 7.5 12.2 3.9 6.8 12.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OpcA_G6PD_assem PF10128.9 EFE43210.1 - 0.013 15.0 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase subunit dsDNA_bind PF01984.20 EFE43211.1 - 3.4e-39 133.5 10.5 4.1e-39 133.3 10.5 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain cwf18 PF08315.12 EFE43211.1 - 0.016 15.9 2.3 0.019 15.6 2.3 1.2 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor SurA_N_2 PF13623.6 EFE43211.1 - 0.23 11.3 2.2 1.8 8.4 0.4 2.0 1 1 1 2 2 2 0 SurA N-terminal domain E_Pc_C PF06752.12 EFE43211.1 - 0.49 10.5 2.9 0.22 11.6 0.8 1.4 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus Coq4 PF05019.13 EFE43212.1 - 9.3e-76 254.0 0.0 1.1e-75 253.8 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 ApbA_C PF08546.11 EFE43213.1 - 9.4e-31 106.6 0.0 1.4e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EFE43213.1 - 4e-25 88.2 0.0 1.5e-23 83.1 0.0 2.2 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Sas10_Utp3 PF04000.15 EFE43214.1 - 7e-16 58.6 0.7 7e-16 58.6 0.7 2.2 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Nop14 PF04147.12 EFE43214.1 - 1 7.5 30.7 1.4 7.1 30.7 1.1 1 0 0 1 1 1 0 Nop14-like family Merozoite_SPAM PF07133.11 EFE43214.1 - 1.8 8.5 28.9 3.9 7.4 28.9 1.5 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nucleo_P87 PF07267.11 EFE43214.1 - 2.4 6.9 12.8 2.9 6.6 12.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DNA_pol_phi PF04931.13 EFE43214.1 - 2.5 6.1 19.3 3.6 5.6 19.3 1.4 1 0 0 1 1 1 0 DNA polymerase phi DUF2076 PF09849.9 EFE43215.1 - 5.8e-09 36.4 11.1 7.4e-09 36.0 11.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 EFE43215.1 - 2.9e-05 24.1 2.5 4.4e-05 23.5 2.5 1.3 1 0 0 1 1 1 1 CHCH domain TFIIA PF03153.13 EFE43215.1 - 0.038 14.0 1.4 0.043 13.8 1.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CX9C PF16860.5 EFE43215.1 - 0.13 12.3 0.3 0.22 11.6 0.3 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, UBX PF00789.20 EFE43216.1 - 2.7e-10 40.3 0.1 6e-10 39.2 0.0 1.6 2 0 0 2 2 2 1 UBX domain SIMPL PF04402.14 EFE43216.1 - 0.017 15.6 3.1 0.017 15.6 3.1 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF541) DUF737 PF05300.11 EFE43216.1 - 1.8 8.9 19.3 0.83 10.0 16.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF737) SURF1 PF02104.15 EFE43217.1 - 5.7e-47 160.2 0.1 1.1e-46 159.3 0.0 1.5 2 0 0 2 2 2 1 SURF1 family CENP-T_C PF15511.6 EFE43218.1 - 9.1e-30 103.0 0.0 1.4e-29 102.4 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFE43218.1 - 1.4e-07 31.7 0.1 2.5e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EFE43218.1 - 7.1e-05 23.2 0.2 0.00014 22.2 0.2 1.5 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFE43218.1 - 0.00078 19.7 0.0 0.0012 19.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bombolitin PF08096.11 EFE43218.1 - 0.03 14.6 0.1 0.058 13.7 0.1 1.5 1 0 0 1 1 1 0 Bombolitin family CENP-X PF09415.10 EFE43218.1 - 0.14 12.5 0.4 0.39 11.1 0.0 1.9 2 0 0 2 2 2 0 CENP-S associating Centromere protein X CMS1 PF14617.6 EFE43219.1 - 5e-76 255.4 0.9 6e-76 255.1 0.9 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EFE43219.1 - 0.00043 20.1 0.0 0.00051 19.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase RRM_1 PF00076.22 EFE43220.1 - 1.5e-11 44.0 1.1 2.1e-11 43.5 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.22 EFE43221.1 - 6.1e-39 133.2 0.0 8.1e-39 132.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE43221.1 - 7e-13 48.9 0.0 1.1e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE43221.1 - 0.014 14.9 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family RhoGAP PF00620.27 EFE43222.1 - 1.2e-45 155.0 0.0 3.2e-45 153.7 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 EFE43222.1 - 7e-13 48.7 0.7 7e-13 48.7 0.7 2.8 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain OmpH PF03938.14 EFE43222.1 - 1.7 9.0 16.1 15 5.9 15.0 2.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) V-ATPase_G_2 PF16999.5 EFE43222.1 - 7.5 7.0 16.8 1.8 9.1 4.4 3.1 3 0 0 3 3 3 0 Vacuolar (H+)-ATPase G subunit SSF PF00474.17 EFE43223.1 - 8e-09 34.8 30.8 4e-08 32.5 30.8 2.1 1 1 0 1 1 1 1 Sodium:solute symporter family MBA1 PF07961.11 EFE43224.1 - 9.3e-09 34.7 0.3 1.8e-08 33.8 0.3 1.4 1 1 0 1 1 1 1 MBA1-like protein SUI1 PF01253.22 EFE43225.1 - 6.3e-27 93.9 4.0 1.7e-26 92.5 4.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 TPR_19 PF14559.6 EFE43225.1 - 0.001 19.5 1.3 0.03 14.8 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFE43225.1 - 0.0011 18.4 0.4 0.0023 17.4 0.4 1.4 1 0 0 1 1 1 1 MalT-like TPR region TPR_12 PF13424.6 EFE43225.1 - 0.0051 17.1 0.8 0.11 12.8 0.0 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat ANAPC5 PF12862.7 EFE43226.1 - 1.3e-31 108.6 0.4 2.9e-31 107.4 0.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 5 Ribosomal_L19e PF01280.20 EFE43226.1 - 3 7.9 7.3 6.9 6.7 7.3 1.5 1 0 0 1 1 1 0 Ribosomal protein L19e SAICAR_synt PF01259.18 EFE43227.1 - 1.3e-93 313.2 0.0 1.6e-93 312.9 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase CIA30 PF08547.12 EFE43228.1 - 8.5e-39 133.1 0.0 5.9e-25 88.1 0.0 2.3 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) Med12 PF09497.10 EFE43229.1 - 2.9e-28 97.9 0.1 1.1e-27 96.1 0.1 2.0 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 Kv2channel PF03521.14 EFE43229.1 - 0.0091 15.4 3.1 0.017 14.5 3.1 1.4 1 0 0 1 1 1 1 Kv2 voltage-gated K+ channel Med12-LCEWAV PF12145.8 EFE43229.1 - 0.036 12.9 0.1 0.16 10.8 0.0 2.0 1 1 1 2 2 2 0 Eukaryotic Mediator 12 subunit domain SKG6 PF08693.10 EFE43230.1 - 0.00034 20.0 0.1 0.00063 19.1 0.1 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Mid2 PF04478.12 EFE43230.1 - 0.047 13.5 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor TMEM51 PF15345.6 EFE43230.1 - 0.066 13.0 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Hemerythrin PF01814.23 EFE43231.1 - 6.7e-13 49.4 0.2 1.1e-12 48.8 0.2 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain MATalpha_HMGbox PF04769.12 EFE43231.1 - 0.028 13.7 0.0 0.04 13.2 0.0 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box MMM1 PF10296.9 EFE43232.1 - 4e-05 22.8 0.0 0.00015 21.0 0.0 1.8 1 1 1 2 2 2 1 Maintenance of mitochondrial morphology protein 1 PH_11 PF15413.6 EFE43232.1 - 0.76 10.2 0.0 0.76 10.2 0.0 2.2 3 0 0 3 3 3 0 Pleckstrin homology domain I_LWEQ PF01608.17 EFE43233.1 - 8.7e-57 191.7 8.0 8.7e-57 191.7 8.0 6.2 3 2 1 6 6 6 2 I/LWEQ domain ANTH PF07651.16 EFE43233.1 - 6.3e-44 150.0 0.0 6.3e-44 150.0 0.0 2.9 2 1 0 2 2 2 1 ANTH domain TcdB_N PF12918.7 EFE43233.1 - 0.074 13.3 5.8 0.12 12.7 2.9 3.1 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain COX6A PF02046.15 EFE43234.1 - 2.3e-52 176.2 1.3 2.8e-52 175.9 1.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Exo_endo_phos PF03372.23 EFE43235.1 - 6e-10 39.0 0.2 1.2e-09 38.0 0.2 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 EFE43235.1 - 0.001 19.1 0.2 0.0026 17.8 0.2 1.7 1 0 0 1 1 1 1 GRF zinc finger HMG_box PF00505.19 EFE43237.1 - 5.2e-16 58.8 4.0 1.6e-07 31.6 0.0 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EFE43237.1 - 0.0015 19.0 1.9 0.5 11.0 0.6 2.4 2 0 0 2 2 2 2 HMG-box domain Hexose_dehydrat PF03559.14 EFE43238.1 - 0.034 13.6 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase Ribosomal_S4e PF00900.20 EFE43239.1 - 3.4e-33 113.4 0.0 1e-32 111.8 0.0 1.9 1 1 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 EFE43239.1 - 1.2e-24 85.6 0.0 2.2e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus S4 PF01479.25 EFE43239.1 - 0.0017 18.0 0.0 0.0034 17.1 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EFE43239.1 - 0.0036 17.2 1.1 0.0036 17.2 1.1 3.2 4 0 0 4 4 4 1 KOW motif FAD-oxidase_C PF02913.19 EFE43240.1 - 9.7e-59 199.0 0.0 1.4e-58 198.5 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFE43240.1 - 5.6e-20 71.5 0.0 1.9e-19 69.8 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Sulfate_transp PF00916.20 EFE43241.1 - 5.7e-117 390.7 17.7 7e-117 390.4 17.7 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EFE43241.1 - 6.3e-08 32.3 0.0 1.3e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EFE43241.1 - 4.9e-05 23.7 3.4 4.9e-05 23.7 3.4 3.0 2 1 0 2 2 2 2 Molybdate transporter of MFS superfamily AA_permease PF00324.21 EFE43242.1 - 0.14 10.7 0.1 0.16 10.6 0.1 1.0 1 0 0 1 1 1 0 Amino acid permease Pkinase PF00069.25 EFE43243.1 - 2.4e-53 181.2 0.0 3.9e-53 180.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43243.1 - 1.7e-23 83.2 0.0 1e-22 80.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EFE43243.1 - 0.014 14.4 0.2 0.021 13.8 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 EFE43243.1 - 0.025 13.9 0.0 6 6.1 0.0 2.4 2 1 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 EFE43243.1 - 2 7.1 7.7 6.8 5.4 7.7 2.1 1 1 0 1 1 1 0 Fungal protein kinase TMA7 PF09072.10 EFE43244.1 - 8.7e-24 84.1 22.1 8.7e-24 84.1 22.1 1.6 2 0 0 2 2 2 1 Translation machinery associated TMA7 Filament PF00038.21 EFE43245.1 - 0.027 14.1 0.2 0.038 13.6 0.2 1.1 1 0 0 1 1 1 0 Intermediate filament protein Fib_alpha PF08702.10 EFE43245.1 - 0.047 13.9 2.8 0.16 12.2 2.8 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 EFE43245.1 - 0.071 13.1 0.7 0.13 12.3 0.7 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Uds1 PF15456.6 EFE43245.1 - 0.4 10.9 1.5 8.3 6.6 1.4 2.2 1 1 1 2 2 2 0 Up-regulated During Septation Cyt-b5 PF00173.28 EFE43246.1 - 2.4e-15 56.4 0.0 3e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF3381 PF11861.8 EFE43246.1 - 0.2 11.4 0.2 0.26 11.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Ish1 PF10281.9 EFE43247.1 - 3.8e-84 276.7 15.2 1.9e-14 53.7 0.0 7.6 7 0 0 7 7 7 7 Putative stress-responsive nuclear envelope protein HeH PF12949.7 EFE43247.1 - 1.8e-08 33.9 0.6 0.34 10.6 0.0 5.1 5 0 0 5 5 5 3 HeH/LEM domain SAP PF02037.27 EFE43247.1 - 7.6e-07 28.7 0.0 0.74 9.6 0.0 4.3 4 0 0 4 4 4 2 SAP domain ANAPC2 PF08672.11 EFE43247.1 - 0.0013 19.2 0.1 49 4.5 0.0 5.1 6 0 0 6 6 6 0 Anaphase promoting complex (APC) subunit 2 Slx4 PF09494.10 EFE43247.1 - 0.0021 18.0 0.2 21 5.2 0.0 4.7 5 0 0 5 5 5 0 Slx4 endonuclease Endonuc-dimeris PF09124.10 EFE43247.1 - 0.006 16.7 0.0 19 5.5 0.0 4.1 5 0 0 5 5 5 0 T4 recombination endonuclease VII, dimerisation LEM PF03020.15 EFE43247.1 - 0.019 14.5 0.0 12 5.6 0.0 3.2 3 0 0 3 3 3 0 LEM domain Recombinase PF07508.13 EFE43247.1 - 0.047 14.1 3.8 2 8.8 0.0 3.9 3 1 0 3 3 3 0 Recombinase OAR PF03826.17 EFE43247.1 - 0.068 13.0 0.0 0.22 11.4 0.0 1.9 1 0 0 1 1 1 0 OAR domain Caudo_TAP PF02413.17 EFE43247.1 - 0.094 12.9 1.2 13 5.9 0.1 2.9 1 1 1 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK SAM_2 PF07647.17 EFE43247.1 - 0.15 12.2 0.2 77 3.5 0.0 4.5 5 0 0 5 5 5 0 SAM domain (Sterile alpha motif) PQ-loop PF04193.14 EFE43248.1 - 1.1e-18 66.8 16.6 1.1e-11 44.3 3.5 3.6 4 0 0 4 4 4 2 PQ loop repeat Arteri_GP4 PF02497.15 EFE43248.1 - 0.045 13.9 0.1 0.096 12.8 0.1 1.5 1 1 0 1 1 1 0 Arterivirus glycoprotein TrbC PF04956.13 EFE43248.1 - 0.047 13.9 4.8 0.094 12.9 3.7 2.1 1 1 0 1 1 1 0 TrbC/VIRB2 family LtrA PF06772.11 EFE43248.1 - 0.071 12.3 8.5 0.011 14.9 2.6 2.2 2 1 1 3 3 3 0 Bacterial low temperature requirement A protein (LtrA) OppC_N PF12911.7 EFE43248.1 - 0.16 12.0 4.8 0.24 11.4 0.1 3.3 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C DUF2951 PF11166.8 EFE43250.1 - 0.029 14.6 0.0 0.062 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) POX PF07526.11 EFE43250.1 - 7.7 7.1 7.0 0.55 10.8 1.4 2.1 2 0 0 2 2 2 0 Associated with HOX GREB1 PF15782.5 EFE43250.1 - 8.9 3.3 12.1 13 2.7 12.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Coilin_N PF15862.5 EFE43251.1 - 0.17 11.7 3.8 0.19 11.5 3.8 1.0 1 0 0 1 1 1 0 Coilin N-terminus CDC45 PF02724.14 EFE43251.1 - 5.6 5.1 9.1 5.4 5.2 9.1 1.0 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EFE43252.1 - 0.00062 19.3 1.1 0.0014 18.1 1.1 1.5 1 0 0 1 1 1 1 SDA1 FAD_binding_4 PF01565.23 EFE43253.1 - 5.7e-16 58.5 3.9 1e-15 57.7 3.9 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE43253.1 - 3.3e-07 30.3 0.1 6.8e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like Aim21 PF11489.8 EFE43254.1 - 7.1e-95 319.5 67.9 7.1e-95 319.5 67.9 2.0 2 0 0 2 2 2 1 Altered inheritance of mitochondria protein 21 Aim21 PF11489.8 EFE43255.1 - 1.6e-67 229.0 23.9 1.6e-67 229.0 23.9 1.5 2 0 0 2 2 2 1 Altered inheritance of mitochondria protein 21 Cg6151-P PF10233.9 EFE43256.1 - 2.9e-39 133.9 12.1 4e-39 133.4 12.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Dpy19 PF10034.9 EFE43256.1 - 0.18 10.0 6.2 0.23 9.6 6.2 1.0 1 0 0 1 1 1 0 Q-cell neuroblast polarisation Trep_Strep PF09605.10 EFE43256.1 - 0.57 10.1 11.0 0.19 11.7 0.6 2.1 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) DUF2721 PF11026.8 EFE43256.1 - 6.9 6.6 11.7 0.67 9.8 3.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Macoilin PF09726.9 EFE43257.1 - 0.11 11.1 8.3 0.16 10.5 8.3 1.2 1 0 0 1 1 1 0 Macoilin family Sortilin-Vps10 PF15902.5 EFE43258.1 - 1.8e-284 943.3 2.0 3.1e-153 510.7 0.5 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EFE43258.1 - 4.5e-93 310.2 21.9 1.9e-47 161.8 8.6 2.4 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EFE43258.1 - 3.2e-08 32.4 28.9 0.44 10.7 0.1 9.4 10 0 0 10 10 10 4 BNR/Asp-box repeat BNR_2 PF13088.6 EFE43258.1 - 0.00023 20.6 0.3 6 6.1 0.0 4.8 3 2 0 4 4 4 2 BNR repeat-like domain CHB_HEX_C PF03174.13 EFE43258.1 - 0.017 15.1 0.4 2.5 8.1 0.0 3.3 3 0 0 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain Transp_cyt_pur PF02133.15 EFE43259.1 - 1.8e-70 238.0 33.2 1.5e-42 145.9 5.1 2.6 1 1 1 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin Mito_carr PF00153.27 EFE43260.1 - 8.1e-66 218.0 0.4 1.8e-22 79.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Cgr1 PF03879.14 EFE43261.1 - 1.6e-33 115.3 30.9 1.6e-33 115.3 30.9 2.9 3 0 0 3 3 3 1 Cgr1 family CSG2 PF16965.5 EFE43261.1 - 1.3 7.9 6.2 0.77 8.6 0.0 2.2 2 0 0 2 2 2 0 Ceramide synthase regulator CLN3 PF02487.17 EFE43261.1 - 2.4 7.1 7.3 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 CLN3 protein SUI1 PF01253.22 EFE43263.1 - 8e-24 84.0 0.2 1.7e-23 83.0 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 R3H-assoc PF13902.6 EFE43263.1 - 0.025 15.0 0.8 0.047 14.1 0.8 1.4 1 0 0 1 1 1 0 R3H-associated N-terminal domain SRP14 PF02290.15 EFE43263.1 - 0.042 14.2 0.3 0.07 13.5 0.3 1.4 1 0 0 1 1 1 0 Signal recognition particle 14kD protein Img2 PF05046.14 EFE43263.1 - 0.045 14.1 0.7 0.074 13.4 0.2 1.7 2 1 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) DUF1752 PF08550.10 EFE43264.1 - 2.8e-10 39.8 2.8 8.2e-10 38.3 2.8 1.9 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) ELMO_CED12 PF04727.13 EFE43265.1 - 1.7e-51 174.8 0.1 2.9e-51 174.1 0.1 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 EFE43265.1 - 7.3e-32 110.7 0.0 1.5e-31 109.7 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain DUF3361 PF11841.8 EFE43265.1 - 1.4e-15 57.5 0.0 3.6e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) Rad17 PF03215.15 EFE43266.1 - 2.1e-26 93.0 0.0 3.6e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EFE43266.1 - 6.8e-05 23.3 0.2 0.00024 21.5 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 EFE43266.1 - 0.0012 18.0 0.0 0.0033 16.5 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 EFE43266.1 - 0.0039 16.9 0.0 0.0072 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFE43266.1 - 0.0079 16.2 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFE43266.1 - 0.016 15.8 4.9 0.058 13.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFE43266.1 - 0.017 15.4 0.0 0.039 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_6 PF12774.7 EFE43266.1 - 0.022 13.7 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_28 PF13521.6 EFE43266.1 - 0.024 14.9 1.6 0.029 14.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFE43266.1 - 0.031 14.7 0.1 0.092 13.2 0.0 1.8 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EFE43266.1 - 0.073 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EFE43266.1 - 0.083 13.0 0.5 0.46 10.6 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EFE43266.1 - 0.088 12.6 1.0 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 EFE43266.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Deoxynucleoside kinase PGA2 PF07543.12 EFE43266.1 - 1.4 8.9 6.9 19 5.2 4.6 2.5 2 0 0 2 2 2 0 Protein trafficking PGA2 UAA PF08449.11 EFE43267.1 - 1.4e-76 257.6 12.1 2.6e-76 256.7 12.1 1.4 1 1 0 1 1 1 1 UAA transporter family TMEM100 PF16311.5 EFE43267.1 - 0.084 12.5 0.4 0.24 11.0 0.4 1.7 1 0 0 1 1 1 0 Transmembrane protein 100 MFS_5 PF05631.14 EFE43268.1 - 1.1e-40 139.7 4.5 1.4e-40 139.4 4.5 1.0 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 EFE43268.1 - 4e-16 58.9 16.1 7e-16 58.1 16.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE43268.1 - 4.8e-10 38.9 9.5 7.8e-10 38.2 9.5 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 EFE43268.1 - 0.00012 20.8 7.5 0.00015 20.5 7.5 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1_like PF12832.7 EFE43268.1 - 0.0017 17.3 0.6 0.0029 16.5 0.2 1.6 1 1 0 1 1 1 1 MFS_1 like family MFS_4 PF06779.14 EFE43268.1 - 0.0056 16.0 9.6 0.0097 15.2 9.6 1.5 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB TetR_C_2 PF08361.11 EFE43268.1 - 0.05 13.7 0.1 5.6 7.1 0.0 2.3 2 0 0 2 2 2 0 MAATS-type transcriptional repressor, C-terminal region MFS_5 PF05631.14 EFE43269.1 - 1.3e-10 40.8 0.3 1.9e-10 40.2 0.3 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM Hydrolase_6 PF13344.6 EFE43270.1 - 9.5e-21 73.8 0.0 2.4e-20 72.5 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE43270.1 - 4.3e-17 61.9 0.0 9.1e-17 60.9 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EFE43270.1 - 0.0087 16.4 0.0 1.6 8.9 0.0 3.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFE43270.1 - 0.039 14.0 0.0 0.58 10.2 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Apt1 PF10351.9 EFE43270.1 - 0.064 12.1 0.0 0.064 12.1 0.0 1.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain PGP_phosphatase PF09419.10 EFE43270.1 - 0.15 11.6 0.0 0.39 10.3 0.0 1.6 1 1 0 1 1 1 0 Mitochondrial PGP phosphatase Aldo_ket_red PF00248.21 EFE43271.1 - 1.6e-52 178.5 0.0 5.5e-52 176.8 0.0 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family TnpV PF14198.6 EFE43271.1 - 0.0089 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Transposon-encoded protein TnpV DUF3818 PF12825.7 EFE43273.1 - 1.4e-120 402.4 8.8 1.4e-112 376.1 7.5 2.5 2 0 0 2 2 2 2 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EFE43273.1 - 2.6e-34 118.0 0.2 5.1e-34 117.1 0.2 1.4 1 0 0 1 1 1 1 PX-associated PX PF00787.24 EFE43273.1 - 1.7e-13 50.6 0.6 2.7e-12 46.6 0.0 3.1 3 1 0 3 3 3 1 PX domain NPV_P10 PF05531.12 EFE43273.1 - 0.14 12.7 0.2 0.35 11.4 0.2 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Met_10 PF02475.16 EFE43276.1 - 1.9e-63 213.8 0.0 2.7e-63 213.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 EFE43276.1 - 0.051 12.7 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase RNA_pol_Rpb4 PF03874.16 EFE43277.1 - 1.8e-22 80.0 0.9 2.5e-22 79.5 0.9 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 Cut8 PF08559.10 EFE43277.1 - 0.0059 16.2 0.3 0.0062 16.2 0.3 1.2 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein POTRA_2 PF08479.11 EFE43277.1 - 0.072 12.9 0.2 7.6 6.5 0.0 2.5 3 0 0 3 3 3 0 POTRA domain, ShlB-type AMP-binding PF00501.28 EFE43278.1 - 2.3e-68 230.8 0.0 4.2e-68 229.9 0.0 1.4 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE43278.1 - 6.7e-06 27.0 0.0 1.3e-05 26.1 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RhoGAP PF00620.27 EFE43279.1 - 2.5e-33 115.1 0.1 5e-33 114.1 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EFE43279.1 - 1.1e-28 99.2 33.9 1.4e-11 44.4 6.1 4.9 5 0 0 5 5 5 4 LIM domain VWA_2 PF13519.6 EFE43281.1 - 1.1e-08 35.7 0.0 3.1e-08 34.2 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain UIM PF02809.20 EFE43281.1 - 0.014 15.3 0.3 0.032 14.2 0.3 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif ANF_receptor PF01094.28 EFE43281.1 - 0.2 10.7 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 Receptor family ligand binding region UQ_con PF00179.26 EFE43283.1 - 1e-14 54.4 0.0 5e-12 45.7 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme UQ_con PF00179.26 EFE43284.1 - 1.4e-08 34.5 0.0 2.4e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFE43284.1 - 6.1e-05 22.7 0.0 9.3e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B FGE-sulfatase PF03781.16 EFE43287.1 - 2.6e-31 109.2 0.1 4.3e-31 108.4 0.1 1.4 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 EFE43287.1 - 3e-06 27.8 0.3 7.5e-06 26.5 0.3 1.8 1 0 0 1 1 1 1 DinB superfamily Methyltransf_25 PF13649.6 EFE43287.1 - 4.7e-06 27.2 0.0 0.00037 21.1 0.0 2.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE43287.1 - 0.00076 20.1 0.0 0.0079 16.8 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Gln-synt_C PF00120.24 EFE43288.1 - 7.8e-48 163.2 0.0 5.6e-47 160.4 0.0 2.0 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain IDO PF01231.18 EFE43289.1 - 3e-30 105.4 0.0 4.2e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase PRORP PF16953.5 EFE43289.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein-only RNase P APH PF01636.23 EFE43291.1 - 2.3e-10 40.8 0.0 1.3e-09 38.4 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family 3Beta_HSD PF01073.19 EFE43292.1 - 4e-45 154.0 0.0 2.1e-44 151.6 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFE43292.1 - 8.5e-16 58.1 0.5 1.2e-14 54.4 0.1 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFE43292.1 - 1.8e-10 40.7 0.0 2.4e-05 23.9 0.0 3.3 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFE43292.1 - 4.6e-10 39.1 0.0 6.2e-08 32.1 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EFE43292.1 - 0.00024 20.3 0.0 0.00069 18.8 0.0 1.7 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFE43292.1 - 0.13 12.1 0.0 2.4 8.0 0.0 2.1 2 0 0 2 2 2 0 NAD(P)H-binding Pkinase PF00069.25 EFE43293.1 - 1.1e-59 202.0 0.0 3.9e-39 134.6 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43293.1 - 6.7e-29 100.9 0.0 5.5e-21 75.0 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EFE43293.1 - 8.6e-13 48.4 0.0 1.7e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EFE43293.1 - 6.3e-08 32.3 0.0 1.2e-05 24.8 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EFE43293.1 - 0.00011 22.2 0.1 0.0055 16.7 0.2 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFE43293.1 - 0.0031 16.9 0.0 0.0057 16.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_9 PF13426.7 EFE43293.1 - 0.0039 17.4 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 PAS domain Haspin_kinase PF12330.8 EFE43293.1 - 0.016 14.1 0.0 0.031 13.2 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain PAS PF00989.25 EFE43293.1 - 0.037 14.0 0.1 0.085 12.9 0.1 1.7 1 0 0 1 1 1 0 PAS fold RIO1 PF01163.22 EFE43293.1 - 0.1 12.2 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 EFE43293.1 - 0.17 10.9 0.1 0.3 10.1 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 eIF-3_zeta PF05091.12 EFE43294.1 - 2.1e-201 670.4 0.0 2.5e-201 670.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) bZIP_1 PF00170.21 EFE43295.1 - 0.011 15.9 12.3 0.15 12.2 12.3 2.3 1 1 0 1 1 1 0 bZIP transcription factor Med9 PF07544.13 EFE43295.1 - 0.022 14.8 4.8 0.11 12.6 4.0 2.2 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 TMCO5 PF14992.6 EFE43295.1 - 0.12 11.9 3.1 0.18 11.3 3.1 1.2 1 0 0 1 1 1 0 TMCO5 family bZIP_2 PF07716.15 EFE43295.1 - 0.66 10.1 11.7 0.11 12.6 4.2 2.3 2 0 0 2 2 2 0 Basic region leucine zipper TEX13 PF15186.6 EFE43295.1 - 2.6 7.7 5.5 4.3 7.0 5.5 1.3 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family F-box-like PF12937.7 EFE43296.1 - 0.0016 18.3 1.2 0.003 17.4 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 EFE43296.1 - 0.013 15.4 0.1 0.036 13.9 0.1 1.8 1 0 0 1 1 1 0 F-box F-box PF00646.33 EFE43296.1 - 0.091 12.7 0.5 0.26 11.2 0.5 1.9 1 0 0 1 1 1 0 F-box domain LRR_6 PF13516.6 EFE43296.1 - 4 7.8 4.4 13 6.2 0.0 3.4 4 0 0 4 4 4 0 Leucine Rich repeat DUF3546 PF12066.8 EFE43298.1 - 3.1e-30 104.6 1.2 3.1e-30 104.6 1.2 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3546) DUF4187 PF13821.6 EFE43298.1 - 9.8e-12 44.5 0.1 2.4e-11 43.2 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ARS2 PF04959.13 EFE43298.1 - 2.4e-11 44.4 0.1 6.1e-11 43.1 0.1 1.9 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF4153 PF13687.6 EFE43299.1 - 0.0094 15.6 0.9 0.0097 15.6 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4153) DUF2956 PF11169.8 EFE43300.1 - 0.002 18.3 3.9 0.0023 18.1 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2956) DUF3464 PF11947.8 EFE43300.1 - 0.0063 16.3 0.6 0.0074 16.0 0.6 1.1 1 0 0 1 1 1 1 Photosynthesis affected mutant 68 Otopetrin PF03189.13 EFE43300.1 - 0.018 13.9 0.5 0.019 13.8 0.5 1.0 1 0 0 1 1 1 0 Otopetrin Orf78 PF06024.12 EFE43300.1 - 0.033 14.5 0.0 0.041 14.2 0.0 1.1 1 0 0 1 1 1 0 Orf78 (ac78) Connexin PF00029.19 EFE43300.1 - 0.047 13.4 1.1 0.052 13.3 1.1 1.1 1 0 0 1 1 1 0 Connexin Claudin_2 PF13903.6 EFE43300.1 - 0.088 12.5 0.0 0.1 12.4 0.0 1.0 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction TMEM208_SND2 PF05620.11 EFE43300.1 - 0.092 12.5 0.1 0.092 12.5 0.1 1.9 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 ATP-synt_E PF05680.12 EFE43300.1 - 0.3 11.4 7.9 0.36 11.2 7.9 1.1 1 0 0 1 1 1 0 ATP synthase E chain SR-25 PF10500.9 EFE43300.1 - 3.4 7.2 20.2 4 7.0 20.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CBFB_NFYA PF02045.15 EFE43302.1 - 9.5e-29 99.8 4.6 2.9e-28 98.3 4.6 1.9 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Hus1 PF04005.12 EFE43302.1 - 0.058 12.5 0.0 0.1 11.7 0.0 1.5 1 0 0 1 1 1 0 Hus1-like protein Kinesin PF00225.23 EFE43304.1 - 1.4e-107 359.5 0.0 2.3e-107 358.8 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 EFE43304.1 - 1.8e-45 155.3 0.0 5.5e-45 153.8 0.0 1.9 1 0 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 EFE43304.1 - 4.9e-37 127.8 15.4 6.6e-32 111.1 0.4 3.6 4 1 1 5 5 5 2 Kinesin-associated Microtub_bd PF16796.5 EFE43304.1 - 2.7e-22 79.3 0.0 6.4e-22 78.1 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding KIF1B PF12423.8 EFE43304.1 - 1.1e-07 32.2 0.2 4.7e-07 30.1 0.2 2.2 1 0 0 1 1 1 1 Kinesin protein 1B FHA PF00498.26 EFE43304.1 - 3.5e-06 27.3 0.2 2e-05 24.8 0.1 2.4 2 0 0 2 2 2 1 FHA domain PH PF00169.29 EFE43304.1 - 0.00013 22.5 0.0 0.00043 20.7 0.0 1.9 2 0 0 2 2 2 1 PH domain UPF0242 PF06785.11 EFE43304.1 - 1.5 8.9 6.7 0.44 10.6 0.9 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus 3-dmu-9_3-mt PF06983.13 EFE43305.1 - 1.9e-38 131.6 0.0 2.5e-38 131.2 0.0 1.2 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase DSX_dimer PF08828.10 EFE43305.1 - 0.015 15.0 0.1 0.028 14.1 0.1 1.5 1 0 0 1 1 1 0 Doublesex dimerisation domain Ham1p_like PF01725.16 EFE43306.1 - 4.2e-48 163.7 0.0 4.8e-48 163.6 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Phosphodiest PF01663.22 EFE43307.1 - 2.8e-86 290.3 0.1 3.7e-86 289.9 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFE43307.1 - 0.00013 21.5 0.0 0.14 11.5 0.0 2.3 1 1 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.18 EFE43307.1 - 0.00081 18.8 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 EFE43307.1 - 0.14 12.3 0.0 0.46 10.6 0.0 1.8 2 0 0 2 2 2 0 PglZ domain HNH_2 PF13391.6 EFE43308.1 - 2.9e-09 36.9 0.0 9.9e-09 35.2 0.0 1.9 1 0 0 1 1 1 1 HNH endonuclease Par3_HAL_N_term PF12053.8 EFE43308.1 - 0.0038 17.4 0.1 0.0038 17.4 0.1 1.9 2 0 0 2 2 2 1 N-terminal of Par3 and HAL proteins MMTV_SAg PF01054.17 EFE43308.1 - 0.12 11.9 0.3 0.2 11.2 0.3 1.3 1 0 0 1 1 1 0 Mouse mammary tumour virus superantigen ATP-synt_E PF05680.12 EFE43308.1 - 3.2 8.1 14.4 5.4 7.4 1.2 3.0 2 1 1 3 3 3 0 ATP synthase E chain PHP_C PF13263.6 EFE43309.1 - 0.025 14.3 0.0 0.058 13.2 0.0 1.6 1 0 0 1 1 1 0 PHP-associated Herpes_US9 PF06072.11 EFE43310.1 - 0.13 12.1 1.6 0.3 11.0 1.6 1.5 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 SNARE PF05739.19 EFE43310.1 - 0.73 9.9 7.2 1.6 8.8 7.2 1.5 1 0 0 1 1 1 0 SNARE domain Prominin PF05478.11 EFE43310.1 - 8.4 4.2 9.1 13 3.6 9.1 1.1 1 0 0 1 1 1 0 Prominin Fic PF02661.18 EFE43311.1 - 2.6e-10 41.1 0.2 5.1e-10 40.1 0.2 1.5 1 0 0 1 1 1 1 Fic/DOC family HLH PF00010.26 EFE43312.1 - 1.5e-15 56.8 0.6 5.8e-15 55.0 0.6 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain eIF-3_zeta PF05091.12 EFE43312.1 - 0.81 8.6 21.5 1.8 7.4 9.2 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ribosomal_S8e PF01201.22 EFE43313.1 - 2.2e-55 186.6 1.6 2.5e-55 186.4 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e Ribonuclease_T2 PF00445.18 EFE43314.1 - 2.6e-40 138.6 2.4 2.6e-40 138.6 2.4 1.6 2 0 0 2 2 2 1 Ribonuclease T2 family GT-D PF08759.11 EFE43314.1 - 0.0029 17.3 0.7 0.0043 16.7 0.7 1.2 1 0 0 1 1 1 1 Glycosyltransferase GT-D fold Tissue_fac PF01108.17 EFE43314.1 - 1 9.3 5.2 7.5 6.4 0.2 2.4 1 1 1 2 2 2 0 Tissue factor SPX PF03105.19 EFE43315.1 - 3.2e-42 145.8 0.3 4.7e-29 102.5 0.1 2.1 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 EFE43315.1 - 5e-29 101.7 42.0 7.3e-29 101.1 42.0 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EFE43315.1 - 8.2e-26 90.9 67.5 3.8e-24 85.4 40.8 2.4 2 1 1 3 3 3 2 Citrate transporter DUF4220 PF13968.6 EFE43315.1 - 0.0037 16.7 0.2 0.011 15.2 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4220) Peptidase_S28 PF05577.12 EFE43316.1 - 6.2e-53 180.1 0.0 3.7e-52 177.6 0.0 1.8 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 EFE43316.1 - 0.077 12.5 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ribosomal_S7 PF00177.21 EFE43317.1 - 4e-29 101.2 0.0 7.4e-29 100.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF1013 PF06242.11 EFE43317.1 - 0.014 15.5 0.5 0.25 11.4 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1013) Na_Ca_ex PF01699.24 EFE43318.1 - 1.9e-37 128.5 31.3 4.8e-22 78.5 15.3 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Orf78 PF06024.12 EFE43318.1 - 0.21 11.9 0.5 0.69 10.3 0.2 2.1 1 1 1 2 2 2 0 Orf78 (ac78) Cyt_bd_oxida_II PF02322.15 EFE43318.1 - 0.31 10.4 17.9 0.018 14.4 3.1 2.3 2 1 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II DUF2157 PF09925.9 EFE43318.1 - 1.1 9.1 6.7 1.8 8.3 0.3 3.2 3 1 0 3 3 3 0 Predicted membrane protein (DUF2157) DUF3810 PF12725.7 EFE43318.1 - 4.3 6.6 7.3 1.3 8.3 0.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3810) PIG-U PF06728.13 EFE43318.1 - 5.3 6.0 13.4 5.9 5.8 5.6 2.3 2 1 0 2 2 2 0 GPI transamidase subunit PIG-U Mucin15 PF15672.5 EFE43319.1 - 8.6e-06 25.5 0.3 8.6e-06 25.5 0.3 2.3 2 0 0 2 2 2 1 Cell-membrane associated Mucin15 SARAF PF06682.12 EFE43319.1 - 0.12 12.0 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3405 PF11885.8 EFE43320.1 - 3.5e-232 771.6 0.6 4.3e-232 771.3 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Voldacs PF03517.13 EFE43323.1 - 0.16 12.1 8.1 0.24 11.5 8.1 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling DUF3050 PF11251.8 EFE43323.1 - 0.21 11.2 1.7 2.5 7.7 0.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3050) Choline_kinase PF01633.20 EFE43324.1 - 9.8e-45 152.7 0.0 1.1e-43 149.4 0.0 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EFE43324.1 - 6.6e-09 36.0 1.5 4e-08 33.5 0.1 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Colicin_immun PF09204.10 EFE43324.1 - 0.15 12.7 0.0 0.36 11.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial self-protective colicin-like immunity CHORD PF04968.12 EFE43325.1 - 1.6e-50 169.7 20.1 8.6e-26 90.4 6.9 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.16 EFE43325.1 - 3.4e-13 50.4 0.1 5.1e-13 49.8 0.1 1.3 1 0 0 1 1 1 1 CS domain BTK PF00779.19 EFE43325.1 - 0.26 11.1 8.9 3.2 7.6 0.3 3.2 3 0 0 3 3 3 0 BTK motif DUF836 PF05768.14 EFE43326.1 - 1e-12 48.3 0.0 1.2e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EFE43326.1 - 0.016 15.4 0.0 0.023 14.9 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin HpcH_HpaI PF03328.14 EFE43327.1 - 6.2e-28 97.5 0.0 1.8e-26 92.7 0.0 2.0 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP_mutase PF13714.6 EFE43327.1 - 0.045 13.2 0.2 2.4 7.5 0.0 2.4 2 0 0 2 2 2 0 Phosphoenolpyruvate phosphomutase Fungal_trans PF04082.18 EFE43328.1 - 2.5e-07 30.0 0.1 4.2e-07 29.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Acyl-CoA_dh_1 PF00441.24 EFE43329.1 - 1.3e-30 106.6 0.4 1.5e-30 106.4 0.4 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 EFE43329.1 - 4.1e-06 27.1 0.1 5e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFE43330.1 - 8.8e-14 52.1 0.1 2.1e-13 50.9 0.1 1.6 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFE43330.1 - 5.6e-11 42.5 0.1 8.4e-11 41.9 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain 14-3-3 PF00244.20 EFE43331.1 - 3.3e-08 33.3 0.1 5.4e-08 32.6 0.1 1.3 1 0 0 1 1 1 1 14-3-3 protein tRNA-synt_1b PF00579.25 EFE43332.1 - 2.7e-21 76.2 0.0 4.6e-20 72.1 0.0 2.4 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) APH PF01636.23 EFE43333.1 - 1.7e-14 54.3 0.2 3e-14 53.5 0.2 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EFE43333.1 - 0.016 14.4 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 Fructosamine kinase SRP72 PF08492.12 EFE43334.1 - 1 9.8 8.4 1.6 9.3 5.5 2.5 2 0 0 2 2 2 0 SRP72 RNA-binding domain MAP17 PF15807.5 EFE43335.1 - 0.00061 20.0 0.1 0.0012 19.0 0.0 1.5 2 0 0 2 2 2 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 GRP PF07172.11 EFE43335.1 - 0.00085 20.0 8.5 0.0012 19.4 8.5 1.2 1 0 0 1 1 1 1 Glycine rich protein family PSI PF01437.25 EFE43335.1 - 0.001 19.6 7.7 0.002 18.6 7.7 1.6 1 0 0 1 1 1 1 Plexin repeat SARAF PF06682.12 EFE43335.1 - 0.0056 16.4 0.0 0.0066 16.2 0.0 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis TNFR_16_TM PF18422.1 EFE43335.1 - 0.02 14.8 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain TM231 PF10149.9 EFE43335.1 - 0.2 11.0 0.1 0.29 10.4 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 231 EphA2_TM PF14575.6 EFE43335.1 - 0.22 12.4 0.0 0.31 11.9 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PSI_integrin PF17205.3 EFE43335.1 - 0.29 10.9 9.4 0.59 9.9 9.4 1.4 1 0 0 1 1 1 0 Integrin plexin domain FeoB_associated PF12669.7 EFE43335.1 - 0.46 10.9 0.0 0.46 10.9 0.0 2.5 2 1 0 2 2 2 0 FeoB-associated Cys-rich membrane protein EMP24_GP25L PF01105.24 EFE43336.1 - 1e-46 159.2 0.1 1.2e-46 158.9 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Vac_ImportDeg PF09783.9 EFE43336.1 - 0.019 14.7 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Vacuolar import and degradation protein Y_Y_Y PF07495.13 EFE43336.1 - 0.061 13.3 0.1 0.14 12.1 0.1 1.6 1 1 0 1 1 1 0 Y_Y_Y domain DUF4793 PF16041.5 EFE43336.1 - 0.07 13.3 0.1 0.2 11.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4793) DUF1408 PF07193.11 EFE43336.1 - 0.15 12.2 0.1 0.25 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1408) Myb_DNA-bind_6 PF13921.6 EFE43337.1 - 0.007 16.6 2.0 0.068 13.4 1.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 EFE43337.1 - 0.063 13.6 1.5 0.16 12.3 0.7 2.1 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like FGF-BP1 PF06473.12 EFE43337.1 - 0.27 11.0 3.3 0.13 12.0 0.3 1.8 1 1 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) PRIMA1 PF16101.5 EFE43337.1 - 4.3 7.4 9.3 3.6 7.7 5.6 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Glyco_hydro_17 PF00332.18 EFE43338.1 - 6.3e-33 114.7 0.0 1.6e-31 110.0 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 DUF2508 PF10704.9 EFE43339.1 - 0.021 15.0 0.4 0.021 15.0 0.4 4.6 6 0 0 6 6 6 0 Protein of unknown function (DUF2508) PAM2 PF07145.15 EFE43339.1 - 0.86 9.4 10.4 13 5.8 0.1 4.3 4 0 0 4 4 4 0 Ataxin-2 C-terminal region PdaC PF13739.6 EFE43339.1 - 6.9 7.7 5.7 5.3 8.1 1.7 3.2 2 0 0 2 2 2 0 Deacetylase PdaC GLE1 PF07817.13 EFE43340.1 - 2.6e-47 161.2 0.0 4.3e-47 160.4 0.0 1.3 1 0 0 1 1 1 1 GLE1-like protein AF-4 PF05110.13 EFE43340.1 - 3.3 5.7 32.9 4.3 5.3 32.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4045 PF13254.6 EFE43340.1 - 8.2 6.0 32.4 12 5.4 32.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) RNB PF00773.19 EFE43342.1 - 1.8e-78 264.2 0.0 4.8e-78 262.8 0.0 1.8 2 0 0 2 2 2 1 RNB domain Dis3l2_C_term PF17877.1 EFE43342.1 - 2.3e-25 88.7 0.0 6.8e-25 87.2 0.0 1.9 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal OB_Dis3 PF17849.1 EFE43342.1 - 1.4e-24 85.9 0.0 3.2e-24 84.7 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EFE43342.1 - 0.00094 19.3 0.0 0.32 11.2 0.0 2.7 2 0 0 2 2 2 2 Cold shock domain Rrp44_CSD1 PF17216.3 EFE43342.1 - 0.0018 18.0 0.0 0.0046 16.7 0.0 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain TFIIA PF03153.13 EFE43342.1 - 0.0047 17.0 12.4 0.0047 17.0 12.4 3.3 2 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit DUF4667 PF15700.5 EFE43342.1 - 0.0098 16.0 2.4 0.0098 16.0 2.4 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4667) UQ_con PF00179.26 EFE43343.1 - 3e-36 124.1 0.0 5.8e-36 123.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFE43343.1 - 0.0062 16.2 1.0 0.016 14.9 0.0 2.2 3 0 0 3 3 3 1 Prokaryotic E2 family B EF1_GNE PF00736.19 EFE43345.1 - 2.6e-32 110.9 0.8 2.6e-32 110.9 0.8 1.5 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EFE43345.1 - 5.2e-07 30.0 1.7 5.2e-07 30.0 1.7 2.0 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region DUF4604 PF15377.6 EFE43345.1 - 0.037 14.4 1.4 0.05 14.0 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) AAA_2 PF07724.14 EFE43346.1 - 3.8e-46 157.3 0.0 1.3e-44 152.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EFE43346.1 - 3.3e-35 120.2 1.8 3.3e-35 120.2 1.8 2.5 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EFE43346.1 - 3.6e-26 91.0 0.0 1.4e-25 89.2 0.0 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EFE43346.1 - 2.7e-17 63.4 0.0 9.8e-09 35.7 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFE43346.1 - 3.2e-12 46.6 0.1 3e-07 30.5 0.0 2.8 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFE43346.1 - 3.3e-08 34.1 9.8 0.00025 21.5 0.1 4.3 3 2 1 4 4 3 2 AAA ATPase domain Sigma54_activat PF00158.26 EFE43346.1 - 7.5e-08 32.3 0.3 0.00033 20.4 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 EFE43346.1 - 2.5e-06 27.8 3.0 0.025 14.8 0.0 3.8 3 2 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 EFE43346.1 - 1.2e-05 25.2 0.0 0.068 12.9 0.0 3.2 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_14 PF13173.6 EFE43346.1 - 3.7e-05 23.8 0.0 0.2 11.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EFE43346.1 - 4.1e-05 23.6 0.3 0.23 11.4 0.0 2.7 3 0 0 3 3 2 2 NACHT domain AAA_7 PF12775.7 EFE43346.1 - 4.4e-05 23.1 0.0 0.067 12.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region TniB PF05621.11 EFE43346.1 - 5e-05 22.8 0.1 0.033 13.6 0.0 3.5 2 1 0 2 2 2 1 Bacterial TniB protein AAA_28 PF13521.6 EFE43346.1 - 0.0004 20.7 1.9 0.036 14.3 0.0 3.3 3 1 1 4 4 3 1 AAA domain AAA_18 PF13238.6 EFE43346.1 - 0.0005 20.6 0.1 1.8 9.1 0.0 3.0 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 EFE43346.1 - 0.00091 19.2 5.9 1.1 9.1 0.1 4.2 3 2 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EFE43346.1 - 0.0013 18.5 0.0 0.64 9.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EFE43346.1 - 0.0015 18.2 0.2 0.21 11.2 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Mg_chelatase PF01078.21 EFE43346.1 - 0.005 16.2 0.1 2.2 7.6 0.1 2.9 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EFE43346.1 - 0.0062 16.9 0.1 2.4 8.6 0.1 2.8 2 1 0 2 2 2 1 RNA helicase ResIII PF04851.15 EFE43346.1 - 0.0065 16.5 0.0 8.6 6.3 0.0 3.0 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFE43346.1 - 0.0069 16.7 0.7 0.2 12.0 0.1 2.8 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFE43346.1 - 0.0075 16.2 0.0 1.7 8.6 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 EFE43346.1 - 0.0093 16.5 1.1 0.6 10.6 0.0 2.9 3 0 0 3 3 3 1 ABC transporter AAA_30 PF13604.6 EFE43346.1 - 0.011 15.5 3.4 0.15 11.8 0.0 3.7 4 0 0 4 4 3 0 AAA domain AAA_25 PF13481.6 EFE43346.1 - 0.012 15.2 0.3 0.22 11.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFE43346.1 - 0.013 15.6 0.1 4.4 7.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EFE43346.1 - 0.014 15.2 0.0 0.52 10.0 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TrwB_AAD_bind PF10412.9 EFE43346.1 - 0.017 14.0 0.1 0.55 9.1 0.1 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 EFE43346.1 - 0.021 14.8 1.2 7.7 6.5 0.0 2.8 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EFE43346.1 - 0.021 14.0 0.3 0.81 8.8 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF815) Roc PF08477.13 EFE43346.1 - 0.023 14.9 0.1 1.7 8.9 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FapA PF03961.13 EFE43346.1 - 0.045 12.4 3.3 0.076 11.6 3.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Zeta_toxin PF06414.12 EFE43346.1 - 0.048 12.9 0.0 4.3 6.6 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin UvrD-helicase PF00580.21 EFE43346.1 - 0.079 12.5 2.5 0.48 9.9 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF2564 PF10819.8 EFE43346.1 - 0.088 13.2 0.2 0.26 11.7 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2564) AAA_21 PF13304.6 EFE43346.1 - 0.1 12.4 0.4 1.2 8.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system HisKA_2 PF07568.12 EFE43346.1 - 0.36 10.9 1.4 1.1 9.3 0.8 2.1 2 0 0 2 2 1 0 Histidine kinase DUF4094 PF13334.6 EFE43346.1 - 0.52 10.8 2.6 0.81 10.1 0.6 2.4 3 0 0 3 3 1 0 Domain of unknown function (DUF4094) V_ATPase_I PF01496.19 EFE43346.1 - 1.1 7.1 3.1 1.5 6.7 3.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MutS_III PF05192.18 EFE43347.1 - 6.5e-15 55.9 0.0 1.1e-14 55.1 0.0 1.4 1 0 0 1 1 1 1 MutS domain III MutS_V PF00488.21 EFE43347.1 - 1.1e-08 35.3 0.1 2.7e-08 34.1 0.1 1.6 1 0 0 1 1 1 1 MutS domain V MutS_IV PF05190.18 EFE43347.1 - 0.021 15.2 0.0 0.046 14.1 0.0 1.6 1 0 0 1 1 1 0 MutS family domain IV Sas10 PF09368.10 EFE43348.1 - 8.6e-29 99.8 7.6 8.6e-29 99.8 7.6 4.4 5 0 0 5 5 5 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EFE43348.1 - 6.4e-12 45.9 0.1 3.3e-11 43.7 0.0 2.4 2 0 0 2 2 2 1 Sas10/Utp3/C1D family adh_short PF00106.25 EFE43349.1 - 2.6e-24 85.8 0.0 3.6e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE43349.1 - 7.3e-12 45.3 0.0 1.2e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE43349.1 - 1.6e-09 37.9 0.1 1.3e-08 35.0 0.1 2.0 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EFE43349.1 - 0.0041 16.4 0.0 0.0078 15.5 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 EFE43349.1 - 0.0093 15.4 0.0 0.019 14.4 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_7 PF13241.6 EFE43349.1 - 0.017 15.6 0.0 0.03 14.8 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 EFE43349.1 - 0.024 14.7 0.1 0.076 13.1 0.1 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 EFE43349.1 - 0.025 14.0 0.0 0.045 13.2 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF3854 PF12965.7 EFE43351.1 - 0.052 13.5 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) Ribosomal_L6e PF01159.19 EFE43352.1 - 1.2e-36 125.6 0.0 1.9e-36 124.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L6e Proteasom_Rpn13 PF04683.13 EFE43353.1 - 6.5e-25 87.5 0.0 1.2e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 EFE43353.1 - 1.9e-13 50.5 1.7 1.3e-12 47.9 2.6 1.8 2 0 0 2 2 2 1 UCH-binding domain DUF3504 PF12012.8 EFE43353.1 - 0.94 9.4 0.0 0.94 9.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) TFB6 PF17110.5 EFE43353.1 - 1.3 8.7 4.3 41 3.9 0.0 2.4 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH eIF3_subunit PF08597.10 EFE43353.1 - 7 6.5 12.9 15 5.4 12.9 1.5 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Ion_trans PF00520.31 EFE43354.1 - 6.2e-127 421.9 89.6 5.4e-40 137.2 8.2 4.6 4 1 0 4 4 4 4 Ion transport protein EF-hand_1 PF00036.32 EFE43354.1 - 0.0014 18.0 0.0 0.0062 16.0 0.0 2.2 2 0 0 2 2 2 1 EF hand GPHH PF16905.5 EFE43354.1 - 0.0043 16.8 0.0 0.01 15.6 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_6 PF13405.6 EFE43354.1 - 0.045 13.7 0.0 0.31 11.1 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain FUN14 PF04930.15 EFE43354.1 - 0.06 13.8 0.3 25 5.4 0.0 2.8 2 0 0 2 2 2 0 FUN14 family EF-hand_7 PF13499.6 EFE43354.1 - 0.064 13.7 0.1 0.35 11.4 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair Aft1_OSA PF11785.8 EFE43354.1 - 0.75 10.3 3.1 2.4 8.7 3.1 1.8 1 0 0 1 1 1 0 Aft1 osmotic stress response (OSM) domain SET PF00856.28 EFE43356.1 - 3.5e-18 66.6 0.1 8.2e-18 65.4 0.1 1.7 1 0 0 1 1 1 1 SET domain Pre-SET PF05033.16 EFE43356.1 - 1.4e-10 41.7 4.4 1.4e-10 41.7 4.4 2.5 3 0 0 3 3 3 1 Pre-SET motif Nop52 PF05997.12 EFE43357.1 - 4.4e-33 114.9 0.0 6.5e-32 111.1 0.0 2.1 1 1 0 1 1 1 1 Nucleolar protein,Nop52 UBD PF16455.5 EFE43358.1 - 3.9e-41 139.5 0.0 6.1e-41 138.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-binding domain baeRF_family2 PF18844.1 EFE43358.1 - 0.0038 17.3 2.4 0.0038 17.3 2.4 1.8 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 2 ubiquitin PF00240.23 EFE43358.1 - 0.021 14.6 0.0 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin family baeRF_family10 PF18854.1 EFE43358.1 - 0.07 13.4 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 ER_lumen_recept PF00810.18 EFE43359.1 - 6.2e-44 150.4 5.0 6.2e-44 150.4 5.0 1.8 2 0 0 2 2 2 1 ER lumen protein retaining receptor DUF485 PF04341.12 EFE43359.1 - 1.5 8.8 8.0 0.14 12.2 0.5 2.7 2 1 1 3 3 3 0 Protein of unknown function, DUF485 DUF382 PF04037.13 EFE43360.1 - 2.9e-59 198.8 1.4 2.9e-59 198.8 1.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 EFE43360.1 - 2.5e-20 72.1 3.7 5.5e-20 71.0 3.7 1.6 1 0 0 1 1 1 1 PSP Ribonuclease_3 PF00636.26 EFE43361.1 - 5.2e-14 52.7 0.0 1e-12 48.6 0.0 2.9 3 0 0 3 3 3 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFE43361.1 - 6.3e-11 42.5 0.0 1.4e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like RIC3 PF15361.6 EFE43361.1 - 0.053 13.9 0.2 0.12 12.7 0.2 1.6 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 dsrm PF00035.26 EFE43361.1 - 0.19 12.4 0.1 0.19 12.4 0.1 2.2 2 0 0 2 2 2 0 Double-stranded RNA binding motif RTA1 PF04479.13 EFE43362.1 - 2.7e-55 187.2 3.0 3.6e-55 186.8 3.0 1.2 1 0 0 1 1 1 1 RTA1 like protein SLED PF12140.8 EFE43363.1 - 0.03 14.8 0.0 0.066 13.7 0.0 1.5 1 0 0 1 1 1 0 SLED domain Ribosomal_S3Ae PF01015.18 EFE43364.1 - 6.7e-85 283.8 5.0 8.3e-85 283.5 5.0 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family SUI1 PF01253.22 EFE43364.1 - 0.011 16.2 0.4 0.064 13.8 0.2 2.2 1 1 1 2 2 2 0 Translation initiation factor SUI1 LPD1 PF18796.1 EFE43364.1 - 0.13 12.4 0.1 0.51 10.5 0.0 2.0 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 1 TipAS PF07739.13 EFE43364.1 - 0.15 12.6 0.0 1.4 9.5 0.0 2.1 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain GTP_CH_N PF12471.8 EFE43365.1 - 2.8e-70 236.0 0.0 5.3e-57 192.7 0.0 2.3 1 1 1 2 2 2 2 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 EFE43365.1 - 3e-14 52.9 0.0 1.5e-13 50.7 0.0 2.1 2 1 0 2 2 2 1 GTP cyclohydrolase II UPRTase PF14681.6 EFE43366.1 - 2.3e-65 220.0 0.0 2.7e-65 219.7 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EFE43366.1 - 0.0094 15.5 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain WAPL PF07814.13 EFE43367.1 - 2.9e-79 266.5 6.8 4.5e-79 265.9 6.8 1.3 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin ATP12 PF07542.11 EFE43368.1 - 2.6e-42 144.0 0.3 3.9e-42 143.4 0.3 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein UnbV_ASPIC PF07593.12 EFE43368.1 - 0.027 14.4 0.1 0.25 11.3 0.1 2.5 2 1 0 2 2 2 0 ASPIC and UnbV Oxysterol_BP PF01237.18 EFE43369.1 - 3.1e-137 457.4 0.0 9.4e-137 455.8 0.0 1.8 2 0 0 2 2 2 1 Oxysterol-binding protein Ank_5 PF13857.6 EFE43369.1 - 3.7e-17 62.2 0.1 4.5e-10 39.6 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFE43369.1 - 1e-16 61.2 0.0 7.6e-08 32.8 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFE43369.1 - 9.2e-13 48.0 0.1 0.0017 18.7 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EFE43369.1 - 5.8e-12 44.7 0.0 0.00076 19.7 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat PH PF00169.29 EFE43369.1 - 1e-10 42.1 0.3 2.4e-10 40.8 0.3 1.7 1 0 0 1 1 1 1 PH domain Ank_4 PF13637.6 EFE43369.1 - 8.2e-09 35.8 0.0 0.00056 20.4 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) PH_8 PF15409.6 EFE43369.1 - 4.9e-07 29.9 0.8 1.3e-06 28.5 0.8 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFE43369.1 - 7.7e-06 26.3 1.6 3e-05 24.4 1.6 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain LLC1 PF14945.6 EFE43369.1 - 0.0037 17.8 1.0 0.0037 17.8 1.0 2.4 2 0 0 2 2 2 1 Normal lung function maintenance, Low in Lung Cancer 1 protein zf-Mss51 PF13824.6 EFE43370.1 - 2.2e-27 94.9 10.3 6.1e-27 93.5 10.3 1.8 1 1 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 EFE43370.1 - 0.0031 17.6 2.5 0.0031 17.6 2.5 2.0 2 0 0 2 2 2 1 MYND finger GRP PF07172.11 EFE43371.1 - 0.018 15.7 25.0 0.37 11.5 25.0 2.2 1 1 0 1 1 1 0 Glycine rich protein family ADH_zinc_N PF00107.26 EFE43372.1 - 4.6e-28 97.8 0.4 7.3e-28 97.1 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFE43372.1 - 3e-11 44.5 0.0 6.1e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE43372.1 - 1.9e-06 27.7 0.0 6.1e-06 26.1 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EFE43372.1 - 0.031 13.7 0.2 0.047 13.2 0.2 1.3 1 0 0 1 1 1 0 short chain dehydrogenase ADH_N_2 PF16884.5 EFE43372.1 - 0.049 13.5 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase HupF_HypC PF01455.18 EFE43372.1 - 0.21 11.8 0.5 0.68 10.1 0.1 2.0 2 0 0 2 2 2 0 HupF/HypC family Pep_deformylase PF01327.21 EFE43372.1 - 0.22 11.1 0.1 0.42 10.2 0.1 1.4 1 0 0 1 1 1 0 Polypeptide deformylase Clr5 PF14420.6 EFE43373.1 - 1.2e-13 51.1 0.9 2.1e-13 50.3 0.9 1.4 1 0 0 1 1 1 1 Clr5 domain SNF2_N PF00176.23 EFE43374.1 - 4.4e-63 213.1 0.7 7e-63 212.5 0.7 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE43374.1 - 3.3e-20 72.5 0.0 1.5e-19 70.4 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EFE43374.1 - 3e-09 37.1 7.1 1.2e-08 35.1 7.1 2.1 1 0 0 1 1 1 1 HSA ResIII PF04851.15 EFE43374.1 - 6e-09 36.1 0.0 1.5e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFE43374.1 - 2.9e-05 23.9 0.2 0.00066 19.5 0.0 2.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase MSA-2c PF12238.8 EFE43374.1 - 4 7.4 12.6 0.09 12.8 5.0 2.1 2 0 0 2 2 2 0 Merozoite surface antigen 2c Membr_traf_MHD PF10540.9 EFE43375.1 - 3.8e-19 69.3 0.2 2.6e-16 60.1 0.2 2.7 1 1 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EFE43375.1 - 1.9e-13 50.6 0.0 4.7e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 EFE43375.1 - 7.1e-07 28.2 0.3 7.1e-07 28.2 0.3 1.7 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) Ribonuc_L-PSP PF01042.21 EFE43376.1 - 6.4e-37 126.3 0.0 7.7e-37 126.0 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP NmrA PF05368.13 EFE43377.1 - 6.5e-11 42.2 0.0 7.8e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFE43377.1 - 2.8e-07 30.6 0.0 4.5e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFE43377.1 - 0.0051 16.3 0.1 2.4 7.5 0.0 2.3 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family Lumazine_bd_2 PF12893.7 EFE43378.1 - 5.7e-27 94.7 0.0 6.7e-27 94.5 0.0 1.0 1 0 0 1 1 1 1 Putative lumazine-binding DUF4878 PF12870.7 EFE43378.1 - 0.0023 18.2 0.2 0.017 15.5 0.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4878) Catalase PF00199.19 EFE43379.1 - 1.6e-136 455.4 0.0 2.2e-136 455.0 0.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EFE43379.1 - 3.9e-05 23.8 0.0 0.0001 22.4 0.0 1.8 1 0 0 1 1 1 1 Catalase-related immune-responsive adh_short PF00106.25 EFE43380.1 - 6.6e-30 104.0 0.0 9.1e-30 103.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE43380.1 - 5.3e-29 101.4 0.0 9.2e-29 100.6 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE43380.1 - 2.3e-12 47.2 0.1 4.2e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFE43380.1 - 0.00025 20.6 0.0 0.0022 17.5 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFE43380.1 - 0.0053 15.9 0.0 0.0081 15.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Methyltransf_33 PF10017.9 EFE43381.1 - 8.5e-79 264.9 0.0 1e-78 264.6 0.0 1.0 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent DUF4363 PF14276.6 EFE43381.1 - 0.045 13.9 0.1 0.098 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) FAD_binding_4 PF01565.23 EFE43382.1 - 1.8e-23 82.8 0.9 3.7e-23 81.8 0.9 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE43382.1 - 9.7e-10 38.4 0.4 2.1e-09 37.3 0.4 1.6 1 0 0 1 1 1 1 Berberine and berberine like Trp_DMAT PF11991.8 EFE43383.1 - 1.5e-108 363.5 0.0 1.7e-108 363.3 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase HD PF01966.22 EFE43386.1 - 0.0058 16.9 0.1 0.013 15.8 0.1 1.6 1 1 0 1 1 1 1 HD domain Glyco_hydro_42M PF08532.10 EFE43387.1 - 0.0075 15.8 0.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 2 Beta-galactosidase trimerisation domain Pribosyltran PF00156.27 EFE43388.1 - 1.4e-11 44.2 0.0 2.3e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MIF4G PF02854.19 EFE43389.1 - 2.6e-52 177.5 0.0 4e-52 176.9 0.0 1.3 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 EFE43389.1 - 2.7e-25 88.3 1.5 7.9e-25 86.8 1.5 1.9 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 Methyltransf_16 PF10294.9 EFE43390.1 - 4.4e-09 36.3 0.2 0.00062 19.5 0.0 2.4 2 1 0 2 2 2 2 Lysine methyltransferase SelP_N PF04592.14 EFE43390.1 - 1.4 8.3 6.1 2.2 7.6 6.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region LVIVD PF08309.11 EFE43391.1 - 6e-05 22.3 0.3 0.11 11.8 0.0 4.0 4 0 0 4 4 4 1 LVIVD repeat Beta_propel PF09826.9 EFE43391.1 - 0.0022 16.9 0.2 0.0098 14.8 0.2 2.1 1 1 0 1 1 1 1 Beta propeller domain c-SKI_SMAD_bind PF08782.10 EFE43391.1 - 0.081 13.2 0.1 0.24 11.7 0.0 1.8 2 0 0 2 2 2 0 c-SKI Smad4 binding domain Med3 PF11593.8 EFE43392.1 - 9.2 5.3 10.4 12 5.0 10.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal AMP-binding PF00501.28 EFE43393.1 - 4.1e-90 302.4 0.0 5.9e-90 301.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE43393.1 - 0.00043 21.2 0.1 0.0011 19.9 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NDT80_PhoG PF05224.12 EFE43396.1 - 2.5e-41 141.9 0.1 3.9e-41 141.3 0.1 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Cyclin_C_2 PF16899.5 EFE43397.1 - 2.6e-36 124.1 0.0 2e-32 111.6 0.0 2.5 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 EFE43397.1 - 0.00036 20.3 0.0 0.00084 19.1 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain ABC_tran PF00005.27 EFE43398.1 - 4.3e-48 163.3 0.0 1.5e-23 83.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EFE43398.1 - 1.9e-21 75.9 3.2 1.9e-21 75.9 3.2 2.7 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 EFE43398.1 - 9.1e-19 68.4 1.7 0.001 19.0 0.0 4.2 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFE43398.1 - 2.1e-11 43.7 0.4 0.001 18.6 0.1 4.4 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFE43398.1 - 3.9e-08 32.9 1.3 0.0028 17.4 0.0 2.8 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EFE43398.1 - 1.4e-07 32.2 5.5 0.029 14.9 0.2 3.9 4 0 0 4 4 4 2 AAA domain AAA_15 PF13175.6 EFE43398.1 - 4.7e-07 29.8 0.1 0.02 14.6 0.0 2.8 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 EFE43398.1 - 1.5e-06 28.2 0.0 0.011 15.8 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFE43398.1 - 2e-06 27.8 0.3 0.0067 16.4 0.0 2.7 3 0 0 3 3 2 2 RsgA GTPase AAA_18 PF13238.6 EFE43398.1 - 3e-06 27.8 0.1 0.092 13.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 EFE43398.1 - 3.8e-06 27.4 0.0 0.025 15.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFE43398.1 - 5.6e-05 23.4 0.0 0.15 12.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_27 PF13514.6 EFE43398.1 - 6e-05 22.7 0.0 0.078 12.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EFE43398.1 - 0.00012 22.4 0.0 0.056 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFE43398.1 - 0.00017 21.5 0.2 0.49 10.3 0.1 2.5 2 0 0 2 2 2 2 NACHT domain Dynamin_N PF00350.23 EFE43398.1 - 0.00019 21.5 2.5 0.36 10.9 0.0 3.6 3 1 0 3 3 3 1 Dynamin family AAA PF00004.29 EFE43398.1 - 0.00024 21.5 0.0 1.1 9.7 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFE43398.1 - 0.00034 21.0 0.7 1.5 9.3 0.0 3.1 3 0 0 3 3 2 2 RNA helicase AAA_5 PF07728.14 EFE43398.1 - 0.00038 20.5 0.1 1.1 9.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EFE43398.1 - 0.00038 20.6 1.7 0.31 11.2 0.1 3.3 4 0 0 4 4 3 1 AAA domain NB-ARC PF00931.22 EFE43398.1 - 0.00065 19.0 0.1 2.7 7.1 0.0 3.3 3 0 0 3 3 3 2 NB-ARC domain Roc PF08477.13 EFE43398.1 - 0.001 19.3 0.1 3.4 7.9 0.0 3.2 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EFE43398.1 - 0.004 16.9 2.9 2.4 7.9 0.0 3.7 4 0 0 4 4 4 1 AAA domain DUF815 PF05673.13 EFE43398.1 - 0.0046 16.1 0.0 0.4 9.8 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EFE43398.1 - 0.0047 16.9 0.0 5.6 7.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFE43398.1 - 0.0057 16.6 0.2 2.2 8.1 0.0 2.8 3 0 0 3 3 2 1 Rad17 P-loop domain DUF2813 PF11398.8 EFE43398.1 - 0.0057 16.0 0.6 0.99 8.6 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF2813) AAA_7 PF12775.7 EFE43398.1 - 0.012 15.1 0.9 2 7.9 0.0 3.0 3 0 0 3 3 3 0 P-loop containing dynein motor region MCM PF00493.23 EFE43398.1 - 0.017 14.2 0.1 1.7 7.7 0.0 2.3 2 0 0 2 2 2 0 MCM P-loop domain NTPase_1 PF03266.15 EFE43398.1 - 0.019 14.9 0.0 1.6 8.6 0.0 2.7 2 0 0 2 2 2 0 NTPase AAA_17 PF13207.6 EFE43398.1 - 0.032 14.7 0.1 34 4.9 0.0 3.5 3 0 0 3 3 3 0 AAA domain GST_C_3 PF14497.6 EFE43398.1 - 0.033 14.4 0.2 0.08 13.1 0.2 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain AAA_25 PF13481.6 EFE43398.1 - 0.039 13.5 0.1 1.1 8.8 0.0 2.8 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.25 EFE43398.1 - 0.04 13.6 0.0 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase_2 PF01637.18 EFE43398.1 - 0.056 13.4 0.2 11 5.8 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea DAP3 PF10236.9 EFE43398.1 - 0.06 12.5 0.4 5.2 6.1 0.1 2.7 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Ras PF00071.22 EFE43398.1 - 0.064 12.8 0.0 6.9 6.2 0.0 2.6 2 0 0 2 2 2 0 Ras family ABC_ATPase PF09818.9 EFE43398.1 - 0.087 11.6 0.3 20 3.8 0.0 3.3 3 1 0 3 3 3 0 Predicted ATPase of the ABC class IstB_IS21 PF01695.17 EFE43398.1 - 0.093 12.5 0.0 2.8 7.6 0.0 2.9 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 EFE43398.1 - 0.096 12.4 1.9 3.4 7.3 0.1 3.1 3 1 0 3 3 3 0 AAA domain FeoB_N PF02421.18 EFE43398.1 - 0.12 11.9 0.0 12 5.4 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.9 EFE43398.1 - 0.12 12.1 2.4 3.8 7.3 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation p450 PF00067.22 EFE43399.1 - 4.2e-27 95.0 0.0 5.7e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 SKG6 PF08693.10 EFE43399.1 - 0.13 11.7 0.3 0.27 10.7 0.3 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain SLC3A2_N PF16028.5 EFE43400.1 - 0.044 13.3 0.3 0.044 13.3 0.3 2.2 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus DUF4267 PF14087.6 EFE43401.1 - 4.3e-24 84.7 2.1 5e-24 84.5 2.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) MFS_1 PF07690.16 EFE43402.1 - 2.9e-37 128.4 53.6 2.8e-36 125.2 53.6 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE43402.1 - 4.3e-15 55.5 11.5 4.3e-15 55.5 11.5 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFE43402.1 - 2.6e-14 52.6 16.0 4e-14 52.0 16.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3522 PF12036.8 EFE43402.1 - 0.4 10.9 5.2 0.099 12.9 0.6 2.4 3 1 0 3 3 3 0 Protein of unknown function (DUF3522) HPP PF04982.13 EFE43403.1 - 2.9e-39 134.0 8.2 5.3e-39 133.2 8.2 1.4 1 0 0 1 1 1 1 HPP family DUF599 PF04654.12 EFE43403.1 - 0.036 13.5 1.9 2.3 7.6 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF599 DUF3377 PF11857.8 EFE43403.1 - 0.038 13.9 0.4 0.094 12.7 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF4922 PF16269.5 EFE43403.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4922) Yip1 PF04893.17 EFE43403.1 - 0.24 11.1 11.4 5.2 6.8 5.5 2.7 1 1 2 3 3 3 0 Yip1 domain GFO_IDH_MocA PF01408.22 EFE43406.1 - 1.3e-18 68.0 0.3 6.2e-12 46.4 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EFE43406.1 - 2e-13 50.3 0.0 3.6e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EFE43406.1 - 0.0035 18.0 0.0 0.0086 16.7 0.0 1.7 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.20 EFE43406.1 - 0.014 15.5 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus IF-2B PF01008.17 EFE43406.1 - 0.04 13.1 0.0 0.091 12.0 0.0 1.5 1 0 0 1 1 1 0 Initiation factor 2 subunit family ATP-grasp_3 PF02655.14 EFE43407.1 - 5.5e-10 39.5 0.0 9e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain MARVEL PF01284.23 EFE43408.1 - 1e-05 25.6 4.1 1.9e-05 24.7 4.1 1.4 1 1 0 1 1 1 1 Membrane-associating domain DUF3245 PF11595.8 EFE43408.1 - 0.2 12.1 2.3 2.7 8.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) RRM_1 PF00076.22 EFE43411.1 - 1.4e-23 82.4 0.4 4.9e-06 26.3 0.0 5.2 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFE43411.1 - 0.017 14.7 0.0 0.47 10.0 0.0 2.6 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) API5 PF05918.11 EFE43411.1 - 0.69 8.7 4.2 1 8.1 4.2 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) GTP_EFTU PF00009.27 EFE43413.1 - 2.1e-55 187.3 0.0 3.6e-55 186.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EFE43413.1 - 3.7e-25 87.8 0.0 9.1e-25 86.6 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EFE43413.1 - 1.2e-16 60.5 0.1 1e-08 35.0 0.0 2.4 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFE43413.1 - 4.5e-06 27.0 0.0 1.3e-05 25.5 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EFE43413.1 - 1.3e-05 25.0 0.0 2.9e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_IV PF03764.18 EFE43413.1 - 0.0078 16.0 0.1 2.9 7.7 0.0 2.6 1 1 1 2 2 2 2 Elongation factor G, domain IV Vps5 PF09325.10 EFE43414.1 - 3e-11 43.4 2.3 6.5e-11 42.2 2.3 1.4 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EFE43414.1 - 1.2e-08 34.9 0.0 2.5e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 PX domain GFA PF04828.14 EFE43415.1 - 4.6e-18 65.3 0.0 5.5e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme APH PF01636.23 EFE43417.1 - 2e-10 41.0 0.0 2.9e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE43417.1 - 0.0036 16.9 0.0 0.0053 16.4 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase TniQ PF06527.11 EFE43417.1 - 0.037 14.7 0.2 0.069 13.9 0.2 1.4 1 0 0 1 1 1 0 TniQ EcKinase PF02958.20 EFE43417.1 - 0.21 10.8 0.0 0.33 10.2 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase THOC2_N PF16134.5 EFE43418.1 - 2.6e-244 812.6 0.0 5.3e-244 811.6 0.0 1.5 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EFE43418.1 - 5e-107 357.6 0.0 7.7e-107 357.0 0.0 1.3 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EFE43418.1 - 3.8e-30 103.8 0.3 1.1e-29 102.3 0.0 2.0 2 0 0 2 2 2 1 Transcription- and export-related complex subunit Plasmodium_Vir PF05795.11 EFE43419.1 - 1.6 8.1 3.6 2.4 7.5 3.6 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein MFS_1 PF07690.16 EFE43420.1 - 3.8e-22 78.7 22.2 5.2e-22 78.3 21.4 1.6 3 0 0 3 3 3 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE43420.1 - 3.2e-10 39.5 12.7 4.9e-10 38.9 12.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter DUF2556 PF10831.8 EFE43421.1 - 7.4 6.6 7.1 5.2 7.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2556) Abhydrolase_1 PF00561.20 EFE43422.1 - 5.6e-48 163.8 0.0 1.8e-47 162.2 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE43422.1 - 0.00018 22.2 3.6 0.00068 20.3 3.6 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF4683 PF15735.5 EFE43423.1 - 0.13 11.9 0.1 0.14 11.7 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4683) MIOX PF05153.15 EFE43424.1 - 9.5e-117 389.0 0.8 1.2e-116 388.6 0.8 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase DUF1796 PF08795.10 EFE43424.1 - 0.005 16.8 0.4 0.0093 15.9 0.4 1.4 1 0 0 1 1 1 1 Putative papain-like cysteine peptidase (DUF1796) HD PF01966.22 EFE43424.1 - 0.061 13.6 0.7 0.87 9.8 0.0 2.6 3 0 0 3 3 3 0 HD domain UBD PF16455.5 EFE43424.1 - 0.095 13.0 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-binding domain Exo_endo_phos PF03372.23 EFE43425.1 - 3.2e-05 23.6 0.0 5.9e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HicA_toxin PF07927.12 EFE43425.1 - 0.078 13.0 0.0 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 HicA toxin of bacterial toxin-antitoxin, DUF2786 PF10979.8 EFE43426.1 - 8.8e-16 57.5 1.0 8.8e-16 57.5 1.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2786) RTC PF01137.21 EFE43427.1 - 1.4e-44 152.0 0.0 2.2e-43 148.0 0.0 2.1 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase 7tm_1 PF00001.21 EFE43429.1 - 0.083 12.2 0.5 0.1 11.9 0.5 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) TSC21 PF15217.6 EFE43430.1 - 0.1 12.6 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 TSC21 family BAR PF03114.18 EFE43431.1 - 4.8e-13 49.3 0.1 7.2e-13 48.7 0.1 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EFE43431.1 - 2e-12 46.5 0.1 3.8e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE43431.1 - 4.1e-12 45.8 0.1 9.8e-12 44.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFE43431.1 - 4.5e-09 35.9 0.1 9.9e-09 34.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PIN_8 PF18476.1 EFE43431.1 - 0.11 12.4 0.1 0.11 12.4 0.1 1.8 3 0 0 3 3 3 0 PIN like domain U1snRNP70_N PF12220.8 EFE43431.1 - 8.3 7.1 9.9 9.2 7.0 1.7 2.8 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF2439 PF10382.9 EFE43433.1 - 5.8e-25 87.4 0.0 1e-24 86.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) DUF4023 PF13215.6 EFE43433.1 - 3.6 7.7 6.8 0.22 11.6 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) Methyltransf_23 PF13489.6 EFE43434.1 - 3.6e-15 56.2 0.0 5.6e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE43434.1 - 1.9e-06 28.5 0.0 9.3e-06 26.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE43434.1 - 5.7e-06 26.9 0.0 4.3e-05 24.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE43434.1 - 8.4e-06 25.7 0.0 9.2e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE43434.1 - 0.0029 18.3 0.0 0.074 13.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Mcp5_PH PF12814.7 EFE43435.1 - 5.3e-44 149.2 0.2 1e-43 148.3 0.2 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EFE43435.1 - 9.6e-05 22.8 0.0 0.00021 21.8 0.0 1.5 1 0 0 1 1 1 1 PH domain kleA_kleC PF17383.2 EFE43435.1 - 4.8 7.6 9.6 0.28 11.5 1.0 3.2 3 0 0 3 3 3 0 Uncharacterized KorC regulated protein A zf-CCCH PF00642.24 EFE43436.1 - 3.8e-08 33.0 2.9 6.8e-08 32.2 2.9 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EFE43436.1 - 1.4e-07 31.3 7.0 3e-07 30.2 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE43436.1 - 4.5e-06 26.6 7.5 1.2e-05 25.3 7.5 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFE43436.1 - 5.9e-06 26.2 10.4 9.8e-06 25.4 10.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFE43436.1 - 6.4e-06 25.9 11.1 1.1e-05 25.1 11.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE43436.1 - 1.5e-05 24.7 12.2 2.7e-05 23.9 12.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFE43436.1 - 1.6e-05 25.1 9.9 3.1e-05 24.2 9.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf_CCCH_4 PF18345.1 EFE43436.1 - 7.7e-05 22.6 6.1 0.00014 21.8 6.1 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-RING_10 PF16685.5 EFE43436.1 - 0.0004 20.5 6.4 0.0011 19.1 6.4 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-CCCH_4 PF18044.1 EFE43436.1 - 0.0025 17.6 3.0 0.0041 16.9 3.0 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-C3HC4_4 PF15227.6 EFE43436.1 - 0.041 14.1 8.7 0.09 12.9 8.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Cript PF10235.9 EFE43436.1 - 0.047 14.2 0.7 0.22 12.1 0.7 2.1 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT Prok-RING_4 PF14447.6 EFE43436.1 - 0.14 12.1 9.2 0.25 11.3 9.2 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EFE43436.1 - 0.55 10.6 6.2 1.4 9.3 6.2 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF5427 PF10310.9 EFE43436.1 - 1.5 7.7 9.9 1.8 7.4 9.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) zf-CCCH_2 PF14608.6 EFE43436.1 - 4.3 8.0 7.2 0.42 11.2 2.6 1.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger TMEM239 PF15841.5 EFE43437.1 - 0.015 15.2 5.1 0.015 15.2 5.1 3.3 1 1 3 4 4 4 0 Transmembrane protein 239 family DUF3431 PF11913.8 EFE43438.1 - 2.6e-75 252.9 0.0 3.2e-75 252.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Myb_DNA-bind_6 PF13921.6 EFE43439.1 - 0.00093 19.4 0.0 0.0019 18.4 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFE43439.1 - 0.046 13.9 0.5 0.12 12.6 0.5 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Pkinase PF00069.25 EFE43440.1 - 1.4e-55 188.5 0.0 1.9e-51 174.9 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43440.1 - 1.8e-26 93.0 0.0 6.4e-25 87.9 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EFE43440.1 - 3.9e-11 43.1 0.0 8.9e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 FHA domain Pkinase_fungal PF17667.1 EFE43440.1 - 1.4e-05 24.1 0.1 5.2e-05 22.2 0.1 2.0 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFE43440.1 - 0.00065 19.1 0.0 0.0013 18.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Yop-YscD_cpl PF16697.5 EFE43440.1 - 0.0012 19.1 0.0 0.0042 17.4 0.0 1.9 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain APH PF01636.23 EFE43440.1 - 0.013 15.4 0.1 0.036 14.0 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family TRAUB PF08164.12 EFE43440.1 - 0.022 15.3 1.3 0.053 14.0 1.3 1.6 1 0 0 1 1 1 0 Apoptosis-antagonizing transcription factor, C-terminal P2X_receptor PF00864.19 EFE43441.1 - 0.024 13.7 0.2 0.037 13.1 0.2 1.1 1 0 0 1 1 1 0 ATP P2X receptor bVLRF1 PF18826.1 EFE43442.1 - 8.5e-62 207.4 0.3 1.9e-61 206.3 0.3 1.6 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EFE43442.1 - 8.8e-05 22.7 0.0 0.00019 21.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EFE43442.1 - 0.00079 19.8 0.1 0.0018 18.6 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 EFE43442.1 - 0.0016 18.7 0.0 0.0049 17.3 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 EFE43442.1 - 0.0051 17.4 0.0 0.012 16.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE43442.1 - 0.16 12.6 0.0 0.38 11.4 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) ABC_membrane PF00664.23 EFE43443.1 - 4.8e-87 292.1 31.3 6.1e-46 157.3 12.1 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE43443.1 - 1.1e-44 152.2 0.0 2.4e-23 83.1 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFE43443.1 - 2.2e-07 30.5 2.1 0.044 13.2 0.1 4.1 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFE43443.1 - 3.9e-06 26.9 2.0 0.036 14.2 0.1 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFE43443.1 - 3.7e-05 23.7 4.6 0.0016 18.3 0.1 2.7 3 0 0 3 3 2 2 RsgA GTPase AAA_16 PF13191.6 EFE43443.1 - 0.001 19.5 0.1 1.4 9.3 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 EFE43443.1 - 0.0018 18.0 0.0 2.5 7.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EFE43443.1 - 0.0021 18.2 0.7 0.19 11.8 0.0 2.7 2 0 0 2 2 2 1 Dynamin family AAA_29 PF13555.6 EFE43443.1 - 0.0026 17.5 0.3 1.6 8.5 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EFE43443.1 - 0.0045 17.5 0.3 0.32 11.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EFE43443.1 - 0.0064 16.8 1.0 3.6 7.9 0.1 3.0 2 1 0 2 2 2 1 AAA domain Roc PF08477.13 EFE43443.1 - 0.012 15.9 3.9 17 5.7 0.0 4.3 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 EFE43443.1 - 0.013 15.6 2.4 1.7 8.7 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain RNA_helicase PF00910.22 EFE43443.1 - 0.019 15.3 0.0 1.7 9.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase DUP PF00674.18 EFE43443.1 - 0.066 13.3 1.3 0.42 10.8 1.3 2.5 1 0 0 1 1 1 0 DUP family DUF720 PF05302.11 EFE43443.1 - 0.071 13.0 0.1 0.21 11.5 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF720) AAA_21 PF13304.6 EFE43443.1 - 0.084 12.7 1.8 0.63 9.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 EFE43443.1 - 0.39 10.4 1.8 14 5.3 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein RNA_pol_Rpc4 PF05132.14 EFE43445.1 - 0.00035 21.0 0.1 0.00037 20.9 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase III RPC4 Afi1 PF07792.12 EFE43445.1 - 0.00097 19.6 0.0 0.001 19.5 0.0 1.2 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4834 PF16118.5 EFE43445.1 - 0.0082 17.1 10.1 0.018 16.0 10.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) CLN3 PF02487.17 EFE43445.1 - 0.0097 15.0 0.4 0.013 14.6 0.4 1.1 1 0 0 1 1 1 1 CLN3 protein G0-G1_switch_2 PF15103.6 EFE43445.1 - 0.014 15.8 4.8 0.021 15.3 4.8 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 Connexin PF00029.19 EFE43445.1 - 0.018 14.8 9.6 0.027 14.2 9.6 1.2 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 EFE43445.1 - 0.02 12.8 3.1 0.023 12.6 3.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EOS1 PF12326.8 EFE43445.1 - 0.021 14.8 0.6 0.025 14.5 0.6 1.3 1 0 0 1 1 1 0 N-glycosylation protein SID-1_RNA_chan PF13965.6 EFE43445.1 - 0.024 13.1 0.1 0.028 12.8 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF5308 PF17233.2 EFE43445.1 - 0.029 14.6 2.4 0.041 14.1 2.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) EMC3_TMCO1 PF01956.16 EFE43445.1 - 0.029 14.1 3.6 0.047 13.4 3.6 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DDHD PF02862.17 EFE43445.1 - 0.036 14.2 2.0 0.043 14.0 2.0 1.1 1 0 0 1 1 1 0 DDHD domain CBP_BcsG PF11658.8 EFE43445.1 - 0.046 12.1 0.1 0.057 11.8 0.1 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG FHIPEP PF00771.20 EFE43445.1 - 0.073 11.5 0.0 0.087 11.3 0.0 1.2 1 0 0 1 1 1 0 FHIPEP family Ion_trans PF00520.31 EFE43445.1 - 0.083 12.1 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Ion transport protein Serinc PF03348.15 EFE43445.1 - 0.088 11.7 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.16 EFE43445.1 - 0.089 12.8 1.6 0.077 13.0 0.5 1.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Otopetrin PF03189.13 EFE43445.1 - 0.19 10.5 0.0 0.76 8.5 0.1 1.5 1 1 0 1 1 1 0 Otopetrin CSG2 PF16965.5 EFE43445.1 - 0.21 10.5 0.1 0.24 10.3 0.1 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Folate_carrier PF01770.18 EFE43445.1 - 0.24 10.1 0.1 0.31 9.7 0.1 1.3 1 0 0 1 1 1 0 Reduced folate carrier GPR15L PF15854.5 EFE43445.1 - 0.4 10.9 14.2 4.2 7.7 14.2 2.2 1 1 0 1 1 1 0 G-protein coupled receptor ligand 15 SpoIIP PF07454.11 EFE43445.1 - 0.47 9.9 10.6 0.54 9.7 10.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RNA_polI_A34 PF08208.11 EFE43445.1 - 0.73 9.9 23.2 0.96 9.5 23.2 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 EFE43445.1 - 1.3 8.8 15.2 1.6 8.5 15.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AIF_C PF14721.6 EFE43445.1 - 2.8 8.3 8.4 4 7.8 8.4 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF2828 PF11443.8 EFE43445.1 - 3.7 5.5 16.9 4.3 5.3 16.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Membralin PF09746.9 EFE43445.1 - 5.3 6.0 6.2 6.3 5.7 6.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein O-antigen_lig PF13425.6 EFE43445.1 - 7.6 5.2 11.7 12 4.5 11.7 1.4 1 1 0 1 1 1 0 O-antigen ligase like membrane protein AAA_11 PF13086.6 EFE43445.1 - 8.4 6.1 15.2 9.8 5.9 15.2 1.1 1 0 0 1 1 1 0 AAA domain Ureide_permease PF07168.11 EFE43445.1 - 8.6 5.0 8.3 13 4.4 8.3 1.2 1 0 0 1 1 1 0 Ureide permease DUF2841 PF11001.8 EFE43448.1 - 4.6e-53 178.5 0.1 7.9e-53 177.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) CorA PF01544.18 EFE43448.1 - 0.043 13.1 0.4 0.064 12.6 0.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Zip PF02535.22 EFE43449.1 - 1.1e-51 176.1 3.9 1.3e-51 175.8 3.9 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter 7TM_transglut PF14402.6 EFE43449.1 - 0.0069 15.9 0.1 0.014 14.8 0.1 1.5 1 0 0 1 1 1 1 7 transmembrane helices usually fused to an inactive transglutaminase SAC3_GANP PF03399.16 EFE43450.1 - 3.9e-90 302.2 4.8 3.9e-90 302.2 4.8 2.4 2 1 1 3 3 3 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EFE43450.1 - 0.00016 21.7 0.4 0.00046 20.2 0.4 1.7 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family CN_hydrolase PF00795.22 EFE43452.1 - 1.6e-05 24.4 0.0 0.083 12.2 0.0 3.0 2 1 2 4 4 4 2 Carbon-nitrogen hydrolase HLH PF00010.26 EFE43453.1 - 5.8e-12 45.4 1.4 1.1e-11 44.5 1.4 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DASH_Dad4 PF08650.10 EFE43453.1 - 0.053 13.5 0.5 0.16 11.9 0.5 1.8 1 1 0 1 1 1 0 DASH complex subunit Dad4 pP_pnuc_1 PF18165.1 EFE43453.1 - 0.88 9.5 4.4 6.7 6.6 4.4 2.2 1 1 0 1 1 1 0 Predicted pPIWI-associating nuclease Mobilization_B PF17511.2 EFE43453.1 - 2.2 8.7 7.8 0.14 12.5 0.9 2.1 1 1 1 2 2 2 0 Mobilization protein B FAD_binding_4 PF01565.23 EFE43454.1 - 2.2e-18 66.4 4.4 4e-18 65.5 4.4 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE43454.1 - 0.0013 18.8 0.0 0.0029 17.7 0.0 1.6 2 0 0 2 2 2 1 Berberine and berberine like Transgly_assoc PF04226.13 EFE43454.1 - 0.008 16.4 4.6 0.017 15.3 4.6 1.6 1 0 0 1 1 1 1 Transglycosylase associated protein F-box-like PF12937.7 EFE43455.1 - 0.08 12.8 0.1 0.35 10.8 0.0 2.1 2 0 0 2 2 2 0 F-box-like Orn_Arg_deC_N PF02784.16 EFE43457.1 - 6e-47 160.1 0.0 1.2e-46 159.2 0.0 1.4 1 1 1 2 2 2 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFE43457.1 - 7.7e-17 61.3 0.0 1e-16 61.0 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF3098 PF11297.8 EFE43457.1 - 0.045 13.4 0.1 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3098) SnoaL_4 PF13577.6 EFE43458.1 - 5.8e-16 58.8 0.0 6.7e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain AMP-binding PF00501.28 EFE43459.1 - 2.7e-142 474.3 0.0 1.7e-72 244.3 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EFE43459.1 - 2.6e-51 174.7 0.0 1.5e-31 109.6 0.0 2.8 2 1 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EFE43459.1 - 2.4e-22 79.0 0.1 1.3e-10 41.5 0.1 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE43459.1 - 2.5e-06 28.3 0.1 0.014 16.3 0.0 3.2 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain p450 PF00067.22 EFE43460.1 - 7.7e-46 156.8 0.0 1e-45 156.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SnoaL_3 PF13474.6 EFE43461.1 - 3.4e-07 30.5 0.2 4.3e-07 30.2 0.2 1.3 1 1 0 1 1 1 1 SnoaL-like domain CaMKII_AD PF08332.10 EFE43461.1 - 0.061 13.5 0.6 0.22 11.7 0.3 1.8 2 0 0 2 2 2 0 Calcium/calmodulin dependent protein kinase II association domain Sulfotransfer_4 PF17784.1 EFE43462.1 - 3.7e-59 200.1 0.1 4.5e-59 199.9 0.1 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EFE43462.1 - 0.004 17.6 0.1 0.014 15.8 0.1 1.9 1 1 0 1 1 1 1 Sulfotransferase family Methyltransf_2 PF00891.18 EFE43463.1 - 3.4e-30 104.9 0.1 1.6e-29 102.8 0.0 2.0 1 1 1 2 2 2 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EFE43463.1 - 0.012 16.3 0.0 0.045 14.5 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_PK PF05891.12 EFE43463.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_12 PF08242.12 EFE43463.1 - 0.028 15.2 0.1 0.13 13.1 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain Dimerisation2 PF16864.5 EFE43463.1 - 0.068 13.2 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain AMP-binding PF00501.28 EFE43464.1 - 3e-70 236.9 0.0 4.6e-70 236.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EFE43464.1 - 5.1e-49 167.2 0.0 1.4e-23 83.4 0.0 3.7 2 2 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EFE43464.1 - 2.1e-21 76.0 4.6 5.7e-06 26.6 0.2 4.3 4 0 0 4 4 4 3 Phosphopantetheine attachment site WES_acyltransf PF03007.16 EFE43464.1 - 0.0034 17.2 0.0 0.0066 16.2 0.0 1.4 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain MFS_1 PF07690.16 EFE43466.1 - 1.9e-29 102.7 14.9 3.1e-25 88.8 7.6 2.5 3 0 0 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE43466.1 - 1.4e-10 40.6 8.7 2.9e-10 39.6 8.8 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 EFE43466.1 - 0.00013 20.6 10.5 0.0002 20.1 6.7 2.6 1 1 0 1 1 1 1 MFS/sugar transport protein MFS_1_like PF12832.7 EFE43466.1 - 0.00052 19.0 7.4 0.00081 18.3 7.4 1.4 1 0 0 1 1 1 1 MFS_1 like family DctQ PF04290.12 EFE43466.1 - 0.0039 17.1 0.1 0.0039 17.1 0.1 2.7 3 1 0 3 3 3 1 Tripartite ATP-independent periplasmic transporters, DctQ component CitMHS PF03600.16 EFE43466.1 - 0.0075 15.5 11.2 0.62 9.2 7.4 2.3 1 1 1 2 2 2 2 Citrate transporter DUF4131 PF13567.6 EFE43466.1 - 0.012 15.2 2.9 2.8 7.6 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Wzy_C PF04932.15 EFE43466.1 - 5.7 6.6 8.9 1.1e+02 2.3 8.9 2.8 1 1 0 1 1 1 0 O-Antigen ligase adh_short_C2 PF13561.6 EFE43467.1 - 5.4e-54 183.2 0.1 6.4e-53 179.7 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE43467.1 - 1.1e-45 155.5 0.1 2.2e-44 151.3 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase HepII_C PF18675.1 EFE43467.1 - 0.0026 17.8 0.0 0.0058 16.7 0.0 1.5 1 0 0 1 1 1 1 Heparinase II C-terminal domain KR PF08659.10 EFE43467.1 - 0.018 15.0 0.2 0.056 13.4 0.2 1.8 1 1 0 1 1 1 0 KR domain RRM_1 PF00076.22 EFE43468.1 - 1.4e-07 31.2 0.1 2e-05 24.3 0.1 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 EFE43468.1 - 2.1e-06 28.0 0.1 4.7e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 PWI domain Nup35_RRM_2 PF14605.6 EFE43468.1 - 2.3e-06 27.5 0.0 7e-05 22.7 0.1 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.24 EFE43468.1 - 0.00048 20.0 1.3 0.00083 19.2 1.3 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFE43468.1 - 0.013 15.5 1.4 0.024 14.7 1.4 1.4 1 0 0 1 1 1 0 Zinc finger domain RRM_occluded PF16842.5 EFE43468.1 - 0.017 15.0 0.0 0.23 11.4 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif UPF0242 PF06785.11 EFE43468.1 - 0.52 10.4 7.1 0.84 9.7 7.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PHM7_cyt PF14703.6 EFE43468.1 - 1.2 9.3 5.6 1.7 8.9 0.1 2.6 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_3 PF08777.11 EFE43468.1 - 2.6 8.1 8.1 2.1 8.4 0.1 2.8 3 0 0 3 3 3 0 RNA binding motif GTP_EFTU PF00009.27 EFE43469.1 - 3.1e-60 203.0 0.1 4.5e-60 202.5 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFE43469.1 - 8e-30 103.1 0.0 4.7e-29 100.6 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EFE43469.1 - 3.9e-21 74.9 0.0 1.4e-20 73.1 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFE43469.1 - 5.2e-13 49.2 0.0 1.9e-12 47.4 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFE43469.1 - 7.5e-12 45.2 0.0 2.1e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EFE43469.1 - 0.00038 20.5 0.1 0.00088 19.3 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Solute_trans_a PF03619.16 EFE43471.1 - 2.2e-59 201.2 1.1 3e-59 200.7 1.1 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Hid1 PF12722.7 EFE43471.1 - 4.5 5.3 6.4 6.5 4.7 6.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Beta_elim_lyase PF01212.21 EFE43473.1 - 1.7e-86 290.2 0.0 2.1e-86 289.8 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EFE43473.1 - 5.2e-09 35.7 0.0 9.5e-09 34.9 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFE43473.1 - 2.5e-05 23.4 0.0 5.5e-05 22.3 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EFE43473.1 - 0.00034 19.3 0.0 0.0012 17.5 0.0 1.9 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EFE43473.1 - 0.0019 17.6 0.0 0.61 9.3 0.0 2.2 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_3 PF00202.21 EFE43473.1 - 0.0099 14.6 0.0 0.051 12.2 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class-III OKR_DC_1 PF01276.20 EFE43473.1 - 0.041 12.6 0.0 0.06 12.1 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Dynactin PF12455.8 EFE43474.1 - 2.9e-100 335.2 1.5 2.9e-100 335.2 1.5 3.5 3 1 0 3 3 3 1 Dynein associated protein CAP_GLY PF01302.25 EFE43474.1 - 2e-20 72.6 0.1 3.3e-20 71.9 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain APG6_N PF17675.1 EFE43474.1 - 0.11 13.0 0.1 0.11 13.0 0.1 8.1 4 2 4 8 8 8 0 Apg6 coiled-coil region HALZ PF02183.18 EFE43474.1 - 0.21 11.9 0.1 0.21 11.9 0.1 7.2 6 1 2 8 8 8 0 Homeobox associated leucine zipper Hydrolase PF00702.26 EFE43476.1 - 1.7e-06 28.5 0.0 2.2e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFE43476.1 - 2.8e-05 24.3 0.0 3.9e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Exo_endo_phos_2 PF14529.6 EFE43477.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase KH_1 PF00013.29 EFE43478.1 - 3.1e-27 94.2 1.5 1.9e-05 24.4 0.1 7.4 7 0 0 7 7 7 6 KH domain Ribosomal_S6 PF01250.17 EFE43478.1 - 0.03 14.6 0.1 0.14 12.5 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein S6 RP-C_C PF11800.8 EFE43478.1 - 6.2 6.9 6.9 13 5.8 6.9 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Chitin_synth_2 PF03142.15 EFE43479.1 - 9.4e-247 819.8 0.9 1.4e-246 819.2 0.9 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 EFE43479.1 - 1.1e-72 245.3 0.0 7.7e-72 242.5 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 EFE43479.1 - 2.5e-19 69.2 0.3 4e-14 52.5 0.1 3.6 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 EFE43479.1 - 5e-15 55.2 0.4 1.3e-14 53.9 0.4 1.8 1 0 0 1 1 1 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 EFE43479.1 - 4.2e-13 49.7 5.0 1.1e-12 48.3 5.0 1.8 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFE43479.1 - 1.2e-10 41.7 0.1 1e-09 38.7 0.1 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFE43479.1 - 0.00023 21.0 0.0 0.074 12.9 0.0 2.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EFE43479.1 - 0.0023 17.5 0.2 0.029 13.8 0.2 2.4 1 1 0 1 1 1 1 Glycosyl transferase family 21 RsgA_GTPase PF03193.16 EFE43479.1 - 0.018 15.0 0.0 0.33 10.9 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EFE43479.1 - 0.06 13.7 0.2 0.23 11.9 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain Chitin_synth_2 PF03142.15 EFE43480.1 - 6.6e-229 760.9 0.1 9.7e-229 760.3 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase DEK_C PF08766.11 EFE43480.1 - 4.8e-17 61.6 0.3 1.8e-16 59.8 0.4 2.0 2 0 0 2 2 2 1 DEK C terminal domain Cyt-b5 PF00173.28 EFE43480.1 - 9e-17 61.0 0.3 2.7e-10 40.2 0.0 2.7 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_trans_2_3 PF13632.6 EFE43480.1 - 1.1e-12 48.3 4.6 2.7e-12 47.0 4.6 1.7 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFE43480.1 - 2.8e-12 47.0 0.1 3.9e-11 43.3 0.1 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Myosin_head PF00063.21 EFE43480.1 - 2.8e-09 35.8 0.0 2.9e-07 29.1 0.0 2.1 1 1 0 2 2 2 2 Myosin head (motor domain) Glyco_transf_21 PF13506.6 EFE43480.1 - 0.00014 21.3 0.0 0.0076 15.7 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EFE43480.1 - 0.00097 19.0 0.0 0.42 10.4 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 TPP_enzyme_N PF02776.18 EFE43481.1 - 6.5e-33 113.8 0.2 2.9e-32 111.6 0.0 2.2 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EFE43481.1 - 1.5e-20 73.5 0.0 2.8e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EFE43481.1 - 2e-13 50.3 0.0 1.5e-12 47.4 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain NTP_transf_3 PF12804.7 EFE43481.1 - 0.049 14.0 0.5 0.67 10.3 0.5 2.6 1 1 0 1 1 1 0 MobA-like NTP transferase domain TatD_DNase PF01026.21 EFE43482.1 - 5e-38 130.9 0.0 8.5e-38 130.2 0.0 1.3 1 0 0 1 1 1 1 TatD related DNase BCDHK_Adom3 PF10436.9 EFE43484.1 - 7.8e-47 159.1 0.0 1.1e-46 158.6 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EFE43484.1 - 4.9e-09 36.7 0.0 2.3e-08 34.5 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EFE43484.1 - 0.031 14.3 0.0 0.088 12.8 0.0 1.8 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain DUF2157 PF09925.9 EFE43485.1 - 0.0045 16.8 0.9 0.0045 16.8 0.9 2.3 2 1 1 3 3 3 1 Predicted membrane protein (DUF2157) DUF3397 PF11877.8 EFE43485.1 - 0.055 13.7 1.9 0.055 13.7 1.9 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3397) SCAMP PF04144.13 EFE43485.1 - 0.78 10.0 7.6 1 9.7 1.3 2.2 2 0 0 2 2 2 0 SCAMP family Ketoacyl-synt_C PF02801.22 EFE43487.1 - 7.3e-35 119.5 0.3 1e-34 119.1 0.3 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 EFE43487.1 - 3.4e-14 53.0 0.5 8.5e-13 48.5 0.1 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_C PF02803.18 EFE43487.1 - 0.0096 15.6 0.4 0.0096 15.6 0.4 2.1 2 1 0 2 2 2 1 Thiolase, C-terminal domain Arginase PF00491.21 EFE43488.1 - 1.2e-86 290.7 0.1 1.5e-86 290.4 0.1 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EFE43488.1 - 0.0025 18.1 0.0 0.0049 17.1 0.0 1.4 1 0 0 1 1 1 1 UPF0489 domain Ras PF00071.22 EFE43489.1 - 5.3e-53 178.9 0.0 6.6e-53 178.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE43489.1 - 9.2e-19 67.8 0.0 1.4e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE43489.1 - 6.5e-07 29.0 0.0 8.3e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Mlh1_C PF16413.5 EFE43490.1 - 4.5e-89 298.4 0.0 7.8e-89 297.6 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EFE43490.1 - 3e-32 110.8 0.1 9.8e-32 109.1 0.0 1.9 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EFE43490.1 - 3.5e-13 49.6 0.0 7.2e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFE43490.1 - 1.4e-06 28.7 0.0 5.3e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DSPc PF00782.20 EFE43491.1 - 4e-06 26.7 0.0 0.00012 21.9 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Condensation PF00668.20 EFE43492.1 - 0 1300.8 0.0 5e-56 190.3 0.0 10.0 9 3 0 9 9 9 9 Condensation domain AMP-binding PF00501.28 EFE43492.1 - 0 1296.2 0.0 1.1e-82 277.9 0.0 5.3 5 0 0 5 5 5 5 AMP-binding enzyme PP-binding PF00550.25 EFE43492.1 - 8.7e-74 243.8 11.0 3.2e-11 43.4 0.3 8.3 8 0 0 8 8 8 7 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE43492.1 - 2.2e-13 50.9 0.1 0.00077 20.4 0.0 5.8 5 0 0 5 5 5 2 AMP-binding enzyme C-terminal domain Transferase PF02458.15 EFE43492.1 - 4.3e-11 42.1 0.1 0.0009 18.0 0.0 5.0 6 0 0 6 6 6 4 Transferase family DUF5122 PF17164.4 EFE43492.1 - 0.34 11.2 1.5 20 5.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller GMP_synt_C PF00958.22 EFE43494.1 - 2.6e-42 142.8 0.0 5.1e-42 141.9 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EFE43494.1 - 1.5e-38 132.5 0.0 2.6e-38 131.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EFE43494.1 - 1.7e-10 40.4 0.1 2.6e-06 26.7 0.1 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EFE43494.1 - 3.6e-07 30.2 0.1 6.3e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase C26 QueC PF06508.13 EFE43494.1 - 0.0011 18.5 0.0 0.0084 15.6 0.0 2.0 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EFE43494.1 - 0.0029 16.4 0.1 0.007 15.2 0.1 1.6 2 0 0 2 2 2 1 tRNA methyl transferase ThiI PF02568.14 EFE43494.1 - 0.0074 15.9 0.1 0.017 14.7 0.1 1.5 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.19 EFE43494.1 - 0.011 15.1 0.1 0.017 14.4 0.1 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase PAPS_reduct PF01507.19 EFE43494.1 - 0.059 13.4 0.0 0.093 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.20 EFE43494.1 - 0.098 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 PP-loop family BCIP PF13862.6 EFE43495.1 - 1.3e-74 250.4 0.1 1.7e-74 250.1 0.1 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein VID27_N PF17748.1 EFE43495.1 - 0.1 12.4 0.4 0.19 11.6 0.4 1.4 1 0 0 1 1 1 0 VID27 N-terminal region WD40 PF00400.32 EFE43497.1 - 2.2e-20 72.6 4.2 5.6e-05 23.8 0.1 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 EFE43497.1 - 7e-05 21.7 0.9 0.1 11.2 0.1 3.9 3 1 1 4 4 4 1 Nucleoporin Nup120/160 APG6_N PF17675.1 EFE43497.1 - 0.0086 16.6 0.4 0.02 15.4 0.4 1.7 1 0 0 1 1 1 1 Apg6 coiled-coil region ANAPC4_WD40 PF12894.7 EFE43497.1 - 0.091 13.1 0.0 25 5.3 0.0 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3450 PF11932.8 EFE43497.1 - 0.097 12.0 0.0 0.2 10.9 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) PI3K_P85_iSH2 PF16454.5 EFE43497.1 - 0.22 11.1 1.2 0.49 10.0 1.2 1.5 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF1664 PF07889.12 EFE43497.1 - 0.55 10.3 1.9 3 7.9 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Sad1_UNC PF07738.13 EFE43498.1 - 0.016 15.2 1.0 0.028 14.5 0.0 1.9 2 0 0 2 2 2 0 Sad1 / UNC-like C-terminal Conotoxin PF02950.17 EFE43499.1 - 0.074 14.1 0.7 0.16 13.0 0.7 1.6 1 0 0 1 1 1 0 Conotoxin DUF2615 PF11027.8 EFE43499.1 - 0.18 12.0 2.0 0.33 11.1 2.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2615) TssO PF17561.2 EFE43499.1 - 6.6 6.8 11.8 6 7.0 0.0 2.1 1 1 1 2 2 2 0 Type VI secretion system, TssO tRNA-synt_1b PF00579.25 EFE43500.1 - 2.3e-10 40.3 0.0 2.9e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Dynamin_N PF00350.23 EFE43500.1 - 0.054 13.6 0.1 0.27 11.3 0.0 1.9 1 1 1 2 2 2 0 Dynamin family Ribosomal_S10 PF00338.22 EFE43501.1 - 3.6e-28 97.7 0.0 6.3e-28 96.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e PNP_UDP_1 PF01048.20 EFE43502.1 - 1.7e-12 47.1 0.7 3.7e-12 46.0 0.7 1.5 1 1 0 1 1 1 1 Phosphorylase superfamily Fcf2 PF08698.11 EFE43503.1 - 1.7e-31 108.4 0.6 1.7e-31 108.4 0.6 2.0 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing Peptidase_S41 PF03572.18 EFE43504.1 - 1.3e-09 37.8 0.0 2.3e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S41 Ribosomal_L7Ae PF01248.26 EFE43505.1 - 1.6e-25 88.6 0.0 1.9e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EFE43505.1 - 0.0002 21.4 0.1 0.00024 21.2 0.1 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 EFE43505.1 - 0.0022 17.8 0.0 0.003 17.4 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RSN1_7TM PF02714.15 EFE43506.1 - 5.5e-90 301.4 17.7 5.5e-90 301.4 17.7 3.1 3 0 0 3 3 3 2 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFE43506.1 - 2.7e-42 144.2 3.7 3.2e-42 144.0 1.1 2.5 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFE43506.1 - 1.8e-36 126.0 0.0 3.2e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EFE43506.1 - 1.1e-28 99.2 0.0 2.6e-28 98.0 0.0 1.7 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter EHN PF06441.12 EFE43508.1 - 1e-33 116.0 4.1 4.3e-33 113.9 0.5 2.4 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EFE43508.1 - 1.5e-10 41.1 0.0 0.00048 19.9 0.0 2.8 3 0 0 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE43508.1 - 1.8e-06 28.7 0.6 3.1e-06 28.0 0.6 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Presenilin PF01080.17 EFE43510.1 - 5 5.8 5.6 5.3 5.7 5.6 1.0 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 EFE43510.1 - 8.3 5.1 10.8 9.9 4.8 10.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4665 PF15679.5 EFE43511.1 - 0.13 12.9 0.1 0.34 11.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4665) Pyridox_oxase_2 PF12766.7 EFE43513.1 - 1.2e-22 80.4 0.0 2e-22 79.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase LRR_9 PF14580.6 EFE43514.1 - 1.3e-50 171.3 0.1 2e-50 170.7 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EFE43514.1 - 8.6e-10 38.2 14.0 6.7e-06 25.8 3.5 2.9 3 1 1 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 EFE43514.1 - 2.5e-06 27.7 8.9 0.0001 22.6 1.4 3.5 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) T4_Gp59_C PF08994.10 EFE43514.1 - 0.017 15.8 0.0 0.028 15.0 0.0 1.3 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term HTH_38 PF13936.6 EFE43514.1 - 0.047 13.4 0.2 0.1 12.4 0.2 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain UPF0128 PF03673.13 EFE43514.1 - 0.087 12.3 0.2 0.21 11.1 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0128) DUF4349 PF14257.6 EFE43514.1 - 0.13 11.6 1.3 0.22 10.9 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) GDA1_CD39 PF01150.17 EFE43515.1 - 4.9e-97 325.3 0.0 7.2e-97 324.7 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Acyltransferase PF01553.21 EFE43516.1 - 1.1e-17 63.9 0.0 2.5e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Pantoate_ligase PF02569.15 EFE43517.1 - 1.7e-81 273.4 0.0 2.9e-81 272.6 0.0 1.3 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase DEAD PF00270.29 EFE43517.1 - 1e-39 136.1 0.0 2.3e-39 135.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE43517.1 - 5e-21 75.1 0.0 9.5e-20 71.0 0.0 2.6 1 1 1 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFE43517.1 - 1.2e-18 67.1 0.0 2.6e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFE43517.1 - 4.5e-06 26.8 0.1 1.9e-05 24.7 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFE43517.1 - 0.016 14.4 0.0 0.036 13.3 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase FAM176 PF14851.6 EFE43517.1 - 8.3 6.1 6.9 0.99 9.1 0.9 2.3 2 0 0 2 2 2 0 FAM176 family WD40 PF00400.32 EFE43518.1 - 1.5e-12 47.8 9.8 8.6e-05 23.2 0.3 6.3 6 1 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE43518.1 - 4.6e-05 23.6 0.4 0.86 9.9 0.1 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ParD_like PF11903.8 EFE43518.1 - 0.038 14.1 0.2 0.085 12.9 0.2 1.5 1 0 0 1 1 1 0 ParD-like antitoxin of type II bacterial toxin-antitoxin system Fungal_trans_2 PF11951.8 EFE43519.1 - 4.4e-09 35.6 5.1 1.7e-07 30.4 0.4 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE43519.1 - 9.3e-06 25.7 10.1 2.3e-05 24.4 10.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box PF00646.33 EFE43520.1 - 1.5e-05 24.7 0.1 3.4e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE43520.1 - 5.1e-05 23.1 1.0 0.00014 21.7 1.0 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFE43520.1 - 0.00083 19.2 1.5 0.0011 18.8 0.1 2.0 2 1 0 2 2 2 1 F-box PPR_2 PF13041.6 EFE43521.1 - 2.5e-41 139.6 12.1 1e-08 35.2 0.0 13.0 11 3 3 14 14 14 7 PPR repeat family PPR_3 PF13812.6 EFE43521.1 - 4.2e-32 110.0 1.3 0.00013 21.9 0.0 10.1 8 3 2 10 10 10 6 Pentatricopeptide repeat domain PPR PF01535.20 EFE43521.1 - 7.7e-24 82.2 15.9 0.0011 19.1 0.0 13.3 14 0 0 14 14 14 4 PPR repeat PPR_long PF17177.4 EFE43521.1 - 2.4e-18 66.3 12.8 1.3e-08 34.5 0.1 5.8 5 1 0 6 6 6 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EFE43521.1 - 1.4e-17 63.1 0.6 9.3e-06 25.2 0.1 9.4 11 0 0 11 11 11 3 PPR repeat RPM2 PF08579.11 EFE43521.1 - 8.7e-08 32.6 0.0 1e-05 25.9 0.0 3.6 4 0 0 4 4 4 1 Mitochondrial ribonuclease P subunit (RPM2) ECSIT PF06239.11 EFE43521.1 - 0.047 12.8 1.1 3.4 6.7 0.0 3.6 4 0 0 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway Rbx_binding PF18113.1 EFE43522.1 - 0.064 13.1 0.0 0.094 12.5 0.0 1.2 1 0 0 1 1 1 0 Rubredoxin binding C-terminal domain Proteasome PF00227.26 EFE43523.1 - 2.7e-48 164.0 0.0 3.3e-48 163.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit SCP2 PF02036.17 EFE43523.1 - 0.033 14.7 0.0 0.079 13.5 0.0 1.6 1 0 0 1 1 1 0 SCP-2 sterol transfer family DUF2373 PF10180.9 EFE43524.1 - 2.3e-21 75.4 0.0 4e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) GCP_C_terminal PF04130.13 EFE43525.1 - 6.3e-102 341.2 0.0 1.3e-101 340.2 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EFE43525.1 - 1e-80 271.6 0.0 1.1e-79 268.3 0.0 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal Mre11_DNA_bind PF04152.14 EFE43525.1 - 0.18 12.1 0.1 0.4 11.0 0.1 1.5 1 0 0 1 1 1 0 Mre11 DNA-binding presumed domain Pkinase PF00069.25 EFE43528.1 - 3.2e-59 200.4 0.0 4.8e-59 199.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43528.1 - 2.7e-41 141.6 0.0 4.2e-41 140.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE43528.1 - 1.6e-10 40.8 0.0 5.8e-07 29.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EFE43528.1 - 0.0024 16.7 0.0 0.0063 15.3 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFE43528.1 - 0.0025 17.2 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RepL PF05732.11 EFE43528.1 - 0.045 13.2 0.1 0.086 12.3 0.1 1.4 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) APH PF01636.23 EFE43528.1 - 0.059 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Rad9 PF04139.13 EFE43529.1 - 6.3e-51 173.2 0.0 7.7e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EFE43529.1 - 0.00051 19.2 0.0 0.0043 16.2 0.0 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Sushi_2 PF09014.10 EFE43529.1 - 0.013 15.4 0.3 0.056 13.3 0.2 2.0 2 0 0 2 2 2 0 Beta-2-glycoprotein-1 fifth domain RCC1 PF00415.18 EFE43530.1 - 3.2e-33 114.1 3.6 9.1e-08 32.6 0.2 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFE43530.1 - 3.1e-13 49.1 21.2 4.8e-05 23.0 0.1 6.1 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Mannitol_dh_C PF08125.13 EFE43531.1 - 5.1e-41 140.8 0.1 1.3e-40 139.5 0.0 1.7 2 0 0 2 2 2 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EFE43531.1 - 1.8e-18 67.1 0.6 4.3e-18 65.9 0.2 1.9 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain Pyr_redox_2 PF07992.14 EFE43531.1 - 0.11 11.7 0.0 0.24 10.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TamB PF04357.13 EFE43531.1 - 0.17 11.1 1.1 0.23 10.6 0.4 1.5 2 0 0 2 2 2 0 TamB, inner membrane protein subunit of TAM complex Sec34 PF04136.15 EFE43533.1 - 1.8e-49 167.4 0.2 3.9e-49 166.4 0.2 1.6 1 0 0 1 1 1 1 Sec34-like family SKA2 PF16740.5 EFE43533.1 - 0.12 12.2 0.0 0.59 9.9 0.0 2.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Pkinase PF00069.25 EFE43535.1 - 2.4e-13 50.0 0.0 6.1e-12 45.5 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43535.1 - 6.3e-10 38.8 0.0 2.6e-09 36.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Aldose_epim PF01263.20 EFE43537.1 - 2.3e-49 168.3 0.2 3.1e-49 167.9 0.2 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Actin PF00022.19 EFE43539.1 - 6.1e-22 77.8 0.0 8.8e-19 67.4 0.0 3.1 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EFE43539.1 - 0.053 12.3 0.0 0.18 10.6 0.0 1.7 2 0 0 2 2 2 0 MreB/Mbl protein XPG_I PF00867.18 EFE43540.1 - 5.4e-22 78.0 0.1 1.1e-21 76.9 0.1 1.6 1 0 0 1 1 1 1 XPG I-region GEN1_C PF18380.1 EFE43540.1 - 5e-16 59.5 0.3 5e-16 59.5 0.3 2.3 1 1 1 2 2 2 1 Holliday junction resolvase Gen1 C-terminal domain XPG_N PF00752.17 EFE43540.1 - 1.8e-07 31.6 0.0 4.5e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EFE43540.1 - 0.023 14.2 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 XPG domain containing Peptidase_M24 PF00557.24 EFE43542.1 - 6.2e-49 166.5 0.0 7e-49 166.3 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 FAD_binding_3 PF01494.19 EFE43543.1 - 3.5e-11 43.0 0.0 4.6e-10 39.3 0.0 2.5 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 EFE43543.1 - 0.0035 16.5 0.0 0.0082 15.2 0.0 1.5 1 1 0 1 1 1 1 Squalene epoxidase Sugar_tr PF00083.24 EFE43545.1 - 7.8e-84 282.1 22.2 9e-84 281.9 22.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE43545.1 - 2.3e-13 49.8 40.0 3.6e-10 39.3 14.1 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFE43545.1 - 0.0035 16.3 5.3 0.0035 16.3 5.3 2.3 2 0 0 2 2 2 2 MFS_1 like family Ribosomal_S8 PF00410.19 EFE43546.1 - 1.4e-08 34.8 0.0 4.2e-08 33.2 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein S8 PIP5K PF01504.18 EFE43548.1 - 2.5e-36 125.4 0.8 1.4e-27 96.6 1.0 2.6 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EFE43548.1 - 5.8e-32 111.0 0.0 1.1e-31 110.1 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EFE43548.1 - 5.8e-15 55.2 4.1 5.8e-15 55.2 4.1 2.0 2 0 0 2 2 2 1 FYVE zinc finger DZR PF12773.7 EFE43548.1 - 0.33 11.0 6.8 0.18 11.8 2.6 2.5 2 0 0 2 2 2 0 Double zinc ribbon C1_1 PF00130.22 EFE43548.1 - 2.1 8.3 10.9 0.021 14.7 2.9 1.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TPP1 PF10341.9 EFE43549.1 - 1.8e-19 69.8 0.0 4e-19 68.6 0.0 1.7 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD Trimer_CC PF08954.11 EFE43549.1 - 7 6.3 6.6 1 8.9 0.1 3.0 3 0 0 3 3 3 0 Trimerisation motif DUF1769 PF08588.10 EFE43552.1 - 6.8e-27 93.4 0.3 1.1e-26 92.7 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) Iso_dh PF00180.20 EFE43553.1 - 3.2e-89 299.5 0.1 7.1e-89 298.3 0.1 1.5 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ICMT PF04140.14 EFE43553.1 - 0.17 12.3 0.0 0.3 11.5 0.0 1.3 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PK PF00224.21 EFE43555.1 - 4.5e-155 515.8 8.2 1.7e-125 418.5 4.7 2.2 1 1 1 2 2 2 2 Pyruvate kinase, barrel domain PK_C PF02887.16 EFE43555.1 - 1.9e-38 131.3 0.0 5.2e-38 129.9 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EFE43555.1 - 0.00016 20.9 0.3 0.00048 19.3 0.1 1.8 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family DUF218 PF02698.17 EFE43555.1 - 0.16 12.0 0.0 0.45 10.5 0.0 1.9 1 1 0 1 1 1 0 DUF218 domain SUR7 PF06687.12 EFE43556.1 - 3.1e-38 131.5 0.2 4.8e-38 130.9 0.2 1.3 1 1 0 1 1 1 1 SUR7/PalI family Tweety PF04906.13 EFE43556.1 - 0.046 12.4 0.2 0.19 10.3 0.0 1.9 2 0 0 2 2 2 0 Tweety Ribosomal_S17_N PF16205.5 EFE43558.1 - 1e-29 102.7 0.3 1.4e-17 63.8 0.0 2.4 2 0 0 2 2 2 2 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EFE43558.1 - 4.9e-27 93.8 0.4 8.9e-27 93.0 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Spc7_N PF15402.6 EFE43559.1 - 0 1069.9 46.3 0 1069.4 46.3 1.2 1 0 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.11 EFE43559.1 - 1.3e-111 372.4 2.6 1.3e-111 372.4 2.6 1.8 2 0 0 2 2 2 1 Spc7 kinetochore protein DUF745 PF05335.13 EFE43559.1 - 0.00037 20.3 2.8 0.00099 18.9 2.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF745) Pil1 PF13805.6 EFE43561.1 - 5e-108 360.6 1.1 3e-55 187.6 0.2 2.2 1 1 0 2 2 2 2 Eisosome component PIL1 XPG_N PF00752.17 EFE43562.1 - 9.1e-35 119.2 0.0 2.2e-34 118.0 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EFE43562.1 - 2.7e-25 88.5 0.0 8e-25 87.0 0.0 1.9 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EFE43562.1 - 0.00012 22.6 0.0 0.00049 20.6 0.0 2.0 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.16 EFE43562.1 - 0.0037 17.5 0.0 0.0092 16.3 0.0 1.6 1 0 0 1 1 1 1 Transposase IS116/IS110/IS902 family HHH_5 PF14520.6 EFE43562.1 - 0.06 14.0 0.0 0.19 12.4 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain WD40 PF00400.32 EFE43563.1 - 2.4e-10 40.8 10.9 6.6e-06 26.8 0.3 7.3 7 0 0 7 7 7 2 WD domain, G-beta repeat DUF5554 PF17709.1 EFE43563.1 - 0.00031 20.8 0.0 0.0012 18.9 0.0 2.0 1 0 0 1 1 1 1 Family of unknown function (DUF5554) Metallophos PF00149.28 EFE43564.1 - 1.7e-37 129.9 0.1 2.7e-37 129.3 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFE43564.1 - 4e-15 56.0 0.0 7e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain HIRA_B PF09453.10 EFE43565.1 - 0.00014 21.6 0.5 0.00039 20.2 0.5 1.8 1 0 0 1 1 1 1 HIRA B motif SMYLE_N PF18615.1 EFE43565.1 - 2.1 7.8 5.2 2.8 7.4 5.2 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Nucleo_P87 PF07267.11 EFE43565.1 - 3.2 6.5 6.5 3.6 6.3 6.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 WD40 PF00400.32 EFE43566.1 - 2.6e-12 47.0 3.1 0.0001 23.0 0.1 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE43566.1 - 1.4e-08 34.9 0.0 9.6e-07 29.0 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFE43566.1 - 0.0028 17.6 0.0 0.0059 16.5 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A DUF3128 PF11326.8 EFE43567.1 - 1.2 9.5 6.1 1.3e+02 3.0 6.1 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) Mst1_SARAH PF11629.8 EFE43568.1 - 0.067 13.3 0.1 0.19 11.9 0.1 1.8 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 YabA PF06156.13 EFE43568.1 - 0.39 11.4 1.6 1.3 9.7 1.6 1.9 1 0 0 1 1 1 0 Initiation control protein YabA Csm1_N PF18504.1 EFE43568.1 - 1.4 9.3 4.8 0.77 10.1 1.4 2.3 2 0 0 2 2 2 0 Csm1 N-terminal domain Gpr1_Fun34_YaaH PF01184.19 EFE43571.1 - 2.4e-79 265.7 16.9 3e-79 265.4 16.9 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family ANTH PF07651.16 EFE43572.1 - 8.5e-16 57.8 0.0 1.1e-08 34.5 0.0 2.2 2 0 0 2 2 2 2 ANTH domain HWE_HK PF07536.14 EFE43572.1 - 0.11 13.2 0.0 0.26 12.0 0.0 1.6 1 0 0 1 1 1 0 HWE histidine kinase Secretin_N_2 PF07655.13 EFE43572.1 - 0.32 11.5 2.5 0.64 10.6 2.5 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain FSA_C PF10479.9 EFE43573.1 - 0.06 11.5 4.2 0.067 11.3 4.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Memo PF01875.17 EFE43574.1 - 1e-22 80.6 0.0 1.4e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Memo-like protein Rad4 PF03835.15 EFE43575.1 - 2.6e-15 56.4 2.9 4.2e-15 55.7 2.9 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 EFE43575.1 - 1.5e-13 51.1 0.4 3.5e-13 50.0 0.4 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box PF00646.33 EFE43577.1 - 0.11 12.4 0.6 0.23 11.4 0.6 1.6 1 0 0 1 1 1 0 F-box domain WD40 PF00400.32 EFE43578.1 - 1.5e-09 38.3 12.8 0.1 13.5 0.0 9.3 10 1 0 10 10 10 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE43578.1 - 1.6e-09 37.9 0.4 0.16 12.3 0.0 6.4 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EFE43578.1 - 6.4e-06 25.9 0.3 0.00013 21.6 0.1 2.7 2 1 0 2 2 2 1 PQQ-like domain Ge1_WD40 PF16529.5 EFE43578.1 - 0.0012 17.9 0.0 0.17 10.8 0.0 3.1 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Lactonase PF10282.9 EFE43578.1 - 0.031 13.5 0.0 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller WD40_like PF17005.5 EFE43578.1 - 0.077 12.3 0.0 0.23 10.8 0.0 1.7 1 1 0 1 1 1 0 WD40-like domain PQQ PF01011.21 EFE43578.1 - 0.13 12.3 1.1 43 4.3 0.1 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat CDC45 PF02724.14 EFE43580.1 - 0.023 13.0 4.1 0.017 13.5 3.1 1.3 1 1 0 1 1 1 0 CDC45-like protein DUF4407 PF14362.6 EFE43580.1 - 0.64 9.3 7.4 1 8.7 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COesterase PF00135.28 EFE43581.1 - 9.6e-55 186.4 0.0 1.6e-54 185.6 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE43581.1 - 2.6e-06 27.4 0.1 1.1e-05 25.4 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold MARVEL PF01284.23 EFE43582.1 - 0.0011 19.0 1.5 0.0015 18.6 1.5 1.3 1 0 0 1 1 1 1 Membrane-associating domain TMEM156 PF15106.6 EFE43582.1 - 0.095 12.1 0.2 0.14 11.5 0.2 1.2 1 0 0 1 1 1 0 TMEM156 protein family EF-1_beta_acid PF10587.9 EFE43582.1 - 0.51 10.8 4.7 0.88 10.1 4.7 1.3 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region NAD_binding_6 PF08030.12 EFE43584.1 - 0.041 14.0 0.1 2.9 8.0 0.0 2.2 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Metallophos PF00149.28 EFE43585.1 - 1.6e-18 68.0 1.9 2.1e-18 67.6 0.3 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFE43585.1 - 4.9e-06 26.8 0.0 0.0017 18.6 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain GCD14 PF08704.10 EFE43586.1 - 7.5e-07 29.1 0.0 0.00042 20.1 0.0 2.5 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 EFE43586.1 - 0.00013 21.7 2.3 0.00023 20.9 1.1 2.0 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_31 PF13847.6 EFE43586.1 - 0.019 14.8 0.0 6.4 6.6 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain HEPN_RnaseLS PF18869.1 EFE43586.1 - 0.051 13.7 0.1 0.092 12.9 0.1 1.3 1 0 0 1 1 1 0 RnaseLS-like HEPN Methyltransf_25 PF13649.6 EFE43586.1 - 0.093 13.4 0.0 2.7 8.7 0.0 2.6 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFE43586.1 - 0.14 12.8 0.0 20 5.9 0.0 2.8 2 1 1 3 3 3 0 Methyltransferase domain SH3-RhoG_link PF16609.5 EFE43586.1 - 0.17 11.6 1.1 2.2 7.9 0.1 2.3 2 0 0 2 2 2 0 SH3-RhoGEF linking unstructured region HET PF06985.11 EFE43587.1 - 4.1e-22 79.1 0.0 7.5e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.16 EFE43588.1 - 1.3e-39 136.2 53.8 6.3e-38 130.6 52.9 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE43588.1 - 1.1e-19 70.4 20.5 7.2e-17 61.0 17.8 2.4 2 1 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFE43588.1 - 3.4e-12 46.0 15.7 3.4e-12 46.0 15.7 2.7 2 0 0 2 2 2 1 Sugar (and other) transporter EptA_B_N PF08019.12 EFE43588.1 - 0.012 15.5 0.1 0.012 15.5 0.1 3.3 4 1 0 4 4 4 0 Phosphoethanolamine transferase EptA/EptB Peptidase_M56 PF05569.11 EFE43588.1 - 0.027 13.7 0.1 0.05 12.8 0.1 1.5 1 0 0 1 1 1 0 BlaR1 peptidase M56 OATP PF03137.20 EFE43588.1 - 3.3 5.9 13.6 0.046 12.0 2.9 2.9 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Exo_endo_phos PF03372.23 EFE43589.1 - 2.3e-22 79.7 0.0 1.7e-21 76.9 0.0 2.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 EFE43589.1 - 1.4e-14 53.6 27.5 1.3e-07 31.3 7.7 2.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFE43589.1 - 1.3e-10 41.4 9.8 3.4e-06 27.3 1.6 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFE43589.1 - 0.045 13.3 0.2 0.084 12.4 0.2 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 EFE43589.1 - 0.3 11.8 5.0 5.4 8.0 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat Macoilin PF09726.9 EFE43589.1 - 0.7 8.4 7.0 0.97 7.9 7.0 1.1 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 EFE43589.1 - 0.85 9.5 26.3 1.6 8.7 26.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.10 EFE43589.1 - 2.3 6.8 9.7 3.8 6.1 9.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pex24p PF06398.11 EFE43591.1 - 0.0006 18.9 0.0 0.00072 18.7 0.0 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Ctr PF04145.15 EFE43591.1 - 0.00071 20.2 1.4 0.0015 19.1 1.4 1.6 1 1 0 1 1 1 1 Ctr copper transporter family Glucos_trans_II PF14264.6 EFE43591.1 - 0.00075 18.9 4.3 0.00092 18.6 4.3 1.1 1 0 0 1 1 1 1 Glucosyl transferase GtrII DUF4834 PF16118.5 EFE43591.1 - 0.0028 18.6 0.1 0.0044 17.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) RIC3 PF15361.6 EFE43591.1 - 0.0033 17.8 0.2 0.0044 17.4 0.2 1.2 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 DUF4181 PF13789.6 EFE43591.1 - 0.0034 17.6 4.6 0.005 17.1 4.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4181) Plasmodium_Vir PF05795.11 EFE43591.1 - 0.0036 16.8 0.7 0.0043 16.5 0.7 1.2 1 0 0 1 1 1 1 Plasmodium vivax Vir protein OATP PF03137.20 EFE43591.1 - 0.0039 15.5 0.9 0.0057 15.0 0.9 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family FAM176 PF14851.6 EFE43591.1 - 0.011 15.4 0.1 0.015 15.0 0.1 1.1 1 0 0 1 1 1 0 FAM176 family 7tm_1 PF00001.21 EFE43591.1 - 0.014 14.7 0.1 0.018 14.4 0.1 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) CRA PF06589.11 EFE43591.1 - 0.018 15.1 0.5 0.031 14.4 0.5 1.3 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) FHIPEP PF00771.20 EFE43591.1 - 0.023 13.2 0.0 0.024 13.1 0.0 1.1 1 0 0 1 1 1 0 FHIPEP family LapA_dom PF06305.11 EFE43591.1 - 0.025 14.4 5.9 0.046 13.5 5.9 1.5 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain SARAF PF06682.12 EFE43591.1 - 0.033 13.8 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Afi1 PF07792.12 EFE43591.1 - 0.036 14.5 1.5 0.05 14.1 1.5 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking OAD_gamma PF04277.13 EFE43591.1 - 0.046 14.3 1.2 0.093 13.3 1.2 1.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Conotoxin PF02950.17 EFE43591.1 - 0.052 14.6 0.1 0.092 13.8 0.1 1.5 1 0 0 1 1 1 0 Conotoxin TMEM208_SND2 PF05620.11 EFE43591.1 - 0.062 13.1 9.3 0.043 13.6 6.5 2.0 1 1 1 2 2 2 0 SRP-independent targeting protein 2/TMEM208 MAP17 PF15807.5 EFE43591.1 - 0.072 13.3 0.4 0.093 13.0 0.4 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF1003 PF06210.11 EFE43591.1 - 0.098 12.8 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) HemY_N PF07219.13 EFE43591.1 - 0.1 12.8 1.1 0.18 12.0 1.1 1.5 1 1 0 1 1 1 0 HemY protein N-terminus SID-1_RNA_chan PF13965.6 EFE43591.1 - 0.13 10.6 4.4 0.11 10.9 1.3 1.8 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 Eapp_C PF10238.9 EFE43591.1 - 0.16 12.1 3.8 0.17 11.9 1.3 1.9 2 0 0 2 2 2 0 E2F-associated phosphoprotein ORC_WH_C PF18137.1 EFE43591.1 - 0.18 11.8 5.4 0.28 11.3 5.4 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Connexin PF00029.19 EFE43591.1 - 0.19 11.4 3.9 0.12 12.1 2.3 1.4 1 1 0 1 1 1 0 Connexin Spore_YhaL PF14147.6 EFE43591.1 - 0.23 11.2 1.2 0.29 10.8 0.3 1.7 1 1 0 1 1 1 0 Sporulation protein YhaL DUF2208 PF09973.9 EFE43591.1 - 0.54 9.8 7.7 1.3 8.6 7.5 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2208) DUF2207 PF09972.9 EFE43591.1 - 1.3 7.7 6.7 0.66 8.7 5.0 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2070 PF09843.9 EFE43591.1 - 1.3 7.2 6.0 1.6 7.0 6.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF2615 PF11027.8 EFE43591.1 - 8.3 6.6 6.6 22 5.2 6.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2615) TLV_coat PF00429.19 EFE43592.1 - 7.4 5.1 5.4 9.1 4.8 5.4 1.0 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) Methyltransf_25 PF13649.6 EFE43593.1 - 1.7e-12 47.9 0.0 3.2e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE43593.1 - 6.5e-11 42.7 0.0 1.9e-10 41.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE43593.1 - 1e-07 31.9 0.0 1.6e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE43593.1 - 8.3e-06 25.3 0.0 1.5e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFE43593.1 - 2.3e-05 25.0 0.1 0.00015 22.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE43593.1 - 6.3e-05 22.9 0.0 0.00011 22.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain 4HBT_2 PF13279.6 EFE43595.1 - 0.00013 22.5 0.0 0.00015 22.3 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily PspB PF06667.12 EFE43595.1 - 0.025 14.6 0.2 0.034 14.2 0.2 1.2 1 0 0 1 1 1 0 Phage shock protein B Kunitz_legume PF00197.18 EFE43596.1 - 0.18 11.7 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Trypsin and protease inhibitor Tweety PF04906.13 EFE43596.1 - 2.2 6.8 6.5 2.2 6.9 5.3 1.5 1 1 0 1 1 1 0 Tweety COG5 PF10392.9 EFE43596.1 - 2.3 8.4 7.6 0.32 11.2 2.8 2.0 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Atg14 PF10186.9 EFE43596.1 - 4.1 6.4 20.6 9.8 5.2 20.6 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LMBR1 PF04791.16 EFE43596.1 - 4.3 6.1 5.4 8.2 5.2 5.4 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Flavin_Reduct PF01613.18 EFE43597.1 - 1.6e-22 80.2 4.0 8.2e-22 77.9 4.0 2.0 1 1 0 1 1 1 1 Flavin reductase like domain Ribosomal_60s PF00428.19 EFE43598.1 - 0.32 11.6 7.2 0.63 10.7 7.2 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Vps5 PF09325.10 EFE43599.1 - 2.2e-89 299.1 4.0 2.2e-89 299.1 4.0 1.4 2 0 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 EFE43599.1 - 2.1e-25 88.9 0.1 5.5e-25 87.6 0.0 1.8 2 0 0 2 2 2 1 PX domain BAR_3 PF16746.5 EFE43599.1 - 0.026 14.2 5.9 0.15 11.7 2.4 2.5 1 1 1 2 2 2 0 BAR domain of APPL family NifQ PF04891.12 EFE43599.1 - 0.39 11.1 1.9 0.87 9.9 1.9 1.5 1 0 0 1 1 1 0 NifQ PilJ PF13675.6 EFE43599.1 - 7.4 6.6 9.0 0.3 11.1 0.4 3.0 3 1 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Aldolase_II PF00596.21 EFE43600.1 - 1.5e-43 148.9 0.0 1.8e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Calreticulin PF00262.18 EFE43601.1 - 2.8e-172 572.7 15.9 2.8e-172 572.7 15.9 1.6 2 0 0 2 2 2 1 Calreticulin family SUR7 PF06687.12 EFE43601.1 - 0.15 11.6 0.1 0.28 10.8 0.1 1.3 1 0 0 1 1 1 0 SUR7/PalI family Aldedh PF00171.22 EFE43602.1 - 9.6e-138 459.5 0.8 1.3e-137 459.1 0.8 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Wtap PF17098.5 EFE43602.1 - 0.036 14.0 0.6 0.073 13.0 0.6 1.5 1 0 0 1 1 1 0 WTAP/Mum2p family HIGH_NTase1 PF05636.11 EFE43602.1 - 0.19 10.9 1.3 0.29 10.3 1.3 1.3 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase Peptidase_M24 PF00557.24 EFE43603.1 - 9.4e-37 126.7 0.4 1.3e-36 126.3 0.4 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 CDC45 PF02724.14 EFE43603.1 - 0.75 8.0 2.4 1.1 7.5 2.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Dynamitin PF04912.14 EFE43605.1 - 1.4e-66 225.4 12.2 7.8e-65 219.7 12.2 2.2 1 1 0 1 1 1 1 Dynamitin Jnk-SapK_ap_N PF09744.9 EFE43605.1 - 0.00099 19.4 10.8 0.0058 16.9 1.0 3.0 3 0 0 3 3 3 1 JNK_SAPK-associated protein-1 TPR_MLP1_2 PF07926.12 EFE43605.1 - 0.0016 18.5 3.1 0.0016 18.5 3.1 3.7 5 0 0 5 5 3 1 TPR/MLP1/MLP2-like protein DivIC PF04977.15 EFE43605.1 - 0.0023 17.6 15.5 0.019 14.7 1.8 3.7 3 0 0 3 3 3 1 Septum formation initiator APG6_N PF17675.1 EFE43605.1 - 0.0025 18.3 12.8 0.51 10.9 2.1 3.4 3 0 0 3 3 3 2 Apg6 coiled-coil region MnmE_helical PF12631.7 EFE43605.1 - 0.0049 17.1 2.8 0.056 13.6 0.2 2.3 2 0 0 2 2 2 1 MnmE helical domain SOGA PF11365.8 EFE43605.1 - 0.0059 17.7 8.1 0.11 13.7 1.7 3.2 3 0 0 3 3 3 1 Protein SOGA DUF2408 PF10303.9 EFE43605.1 - 0.0068 17.0 3.7 0.89 10.1 0.4 3.3 2 1 1 3 3 3 1 Protein of unknown function (DUF2408) Laminin_II PF06009.12 EFE43605.1 - 0.012 15.6 0.5 0.012 15.6 0.5 3.2 4 1 1 5 5 4 0 Laminin Domain II DUF812 PF05667.11 EFE43605.1 - 0.023 13.6 3.7 0.016 14.2 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DUF2203 PF09969.9 EFE43605.1 - 0.027 15.2 7.2 0.56 10.9 0.8 3.7 3 1 1 4 4 3 0 Uncharacterized conserved protein (DUF2203) pPIWI_RE_REase PF18154.1 EFE43605.1 - 0.028 14.4 0.1 0.064 13.2 0.1 1.5 1 0 0 1 1 1 0 REase associating with pPIWI_RE SKA2 PF16740.5 EFE43605.1 - 0.032 14.0 4.7 0.35 10.7 0.0 3.3 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF4618 PF15397.6 EFE43605.1 - 0.035 13.5 2.7 0.94 8.8 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) ADIP PF11559.8 EFE43605.1 - 0.054 13.6 9.6 0.46 10.6 0.5 3.4 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4200 PF13863.6 EFE43605.1 - 0.058 13.8 13.0 0.65 10.4 3.8 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) DUF4407 PF14362.6 EFE43605.1 - 0.066 12.5 15.7 4.5 6.5 9.1 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) SlyX PF04102.12 EFE43605.1 - 0.069 13.8 16.7 0.16 12.6 1.8 4.7 4 1 1 5 5 5 0 SlyX FH2 PF02181.23 EFE43605.1 - 0.11 11.6 4.4 0.097 11.8 0.2 2.6 3 0 0 3 3 3 0 Formin Homology 2 Domain Muted PF14942.6 EFE43605.1 - 0.12 12.7 9.1 3.2 8.1 2.0 3.2 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein DUF16 PF01519.16 EFE43605.1 - 0.16 12.5 4.1 0.18 12.3 0.7 2.7 3 0 0 3 3 2 0 Protein of unknown function DUF16 Spc7 PF08317.11 EFE43605.1 - 0.19 10.6 11.1 0.088 11.7 2.5 2.9 3 0 0 3 3 3 0 Spc7 kinetochore protein Atg14 PF10186.9 EFE43605.1 - 0.21 10.6 9.1 0.98 8.4 0.7 2.6 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cob_adeno_trans PF01923.18 EFE43605.1 - 0.27 11.3 5.2 26 4.9 0.6 3.2 3 0 0 3 3 3 0 Cobalamin adenosyltransferase OmpH PF03938.14 EFE43605.1 - 0.39 11.1 12.4 0.6 10.4 3.5 3.2 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Fmp27_WPPW PF10359.9 EFE43605.1 - 0.41 9.4 6.0 1.7 7.4 0.7 2.9 3 0 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain ZapB PF06005.12 EFE43605.1 - 0.42 11.1 10.9 7.6 7.1 2.2 3.7 3 0 0 3 3 3 0 Cell division protein ZapB FapA PF03961.13 EFE43605.1 - 0.44 9.1 2.3 4.2 5.9 0.3 2.2 2 0 0 2 2 2 0 Flagellar Assembly Protein A Golgin_A5 PF09787.9 EFE43605.1 - 0.5 9.8 8.0 0.46 9.9 1.4 2.4 2 0 0 2 2 2 0 Golgin subfamily A member 5 LPP PF04728.13 EFE43605.1 - 0.51 10.8 13.8 0.52 10.8 0.6 4.6 4 0 0 4 4 4 0 Lipoprotein leucine-zipper Csm1_N PF18504.1 EFE43605.1 - 0.55 10.6 13.5 3.6 8.0 1.7 3.6 3 0 0 3 3 3 0 Csm1 N-terminal domain Ax_dynein_light PF10211.9 EFE43605.1 - 0.6 10.0 9.0 4.6 7.2 1.2 2.7 3 0 0 3 3 2 0 Axonemal dynein light chain Prefoldin_2 PF01920.20 EFE43605.1 - 0.62 10.1 14.0 2.2 8.3 3.5 3.6 3 1 0 3 3 3 0 Prefoldin subunit FliD_C PF07195.12 EFE43605.1 - 0.74 9.2 4.9 0.49 9.8 2.2 2.0 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Phage_Mu_Gam PF07352.12 EFE43605.1 - 0.84 9.5 6.7 0.96 9.3 0.2 3.0 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein Spc24 PF08286.11 EFE43605.1 - 0.92 9.8 13.8 3.7 7.9 2.1 3.7 4 0 0 4 4 3 0 Spc24 subunit of Ndc80 BLOC1_2 PF10046.9 EFE43605.1 - 1 9.7 5.3 1.2 9.4 0.2 3.3 4 0 0 4 4 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DHR10 PF18595.1 EFE43605.1 - 1.3 9.1 20.4 0.069 13.2 2.1 3.5 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain DUF1664 PF07889.12 EFE43605.1 - 1.3 9.1 5.4 0.84 9.7 0.6 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) JIP_LZII PF16471.5 EFE43605.1 - 1.5 9.1 13.8 0.54 10.5 3.6 3.5 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II DUF724 PF05266.14 EFE43605.1 - 1.7 8.4 6.7 4.3 7.1 0.9 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF724) Spectrin PF00435.21 EFE43605.1 - 1.8 9.1 10.8 33 5.0 3.6 3.5 3 0 0 3 3 3 0 Spectrin repeat KxDL PF10241.9 EFE43605.1 - 1.8 8.9 5.7 0.59 10.5 0.7 2.6 3 0 0 3 3 2 0 Uncharacterized conserved protein DUF3584 PF12128.8 EFE43605.1 - 2.2 5.7 13.6 0.73 7.3 2.9 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF3584) Herpes_BLRF2 PF05812.12 EFE43605.1 - 2.3 8.3 7.1 1 9.5 1.2 2.7 3 0 0 3 3 2 0 Herpesvirus BLRF2 protein COG2 PF06148.11 EFE43605.1 - 2.4 8.2 5.1 2.9 8.0 0.4 2.8 3 0 0 3 3 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4140 PF13600.6 EFE43605.1 - 2.5 8.6 17.8 4.1 7.9 0.5 4.4 3 2 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Uds1 PF15456.6 EFE43605.1 - 2.5 8.3 14.1 5.2 7.3 0.3 3.7 2 1 0 2 2 2 0 Up-regulated During Septation UPF0242 PF06785.11 EFE43605.1 - 2.8 8.0 6.1 35 4.4 0.4 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus TMPIT PF07851.13 EFE43605.1 - 3.9 6.6 4.7 1.6 7.9 0.7 2.2 3 0 0 3 3 2 0 TMPIT-like protein Fib_alpha PF08702.10 EFE43605.1 - 4.2 7.5 5.0 2.2 8.5 0.4 2.8 4 1 0 4 4 2 0 Fibrinogen alpha/beta chain family DUF4337 PF14235.6 EFE43605.1 - 5 7.2 11.4 3.6 7.7 0.8 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4337) Snapin_Pallidin PF14712.6 EFE43605.1 - 6 7.4 11.8 3.3 8.2 1.5 4.5 3 2 0 3 3 3 0 Snapin/Pallidin Phage_GP20 PF06810.11 EFE43605.1 - 8.6 6.2 11.4 1.1 9.1 1.4 3.1 3 0 0 3 3 3 0 Phage minor structural protein GP20 Cnn_1N PF07989.11 EFE43605.1 - 9.2 6.5 12.7 6.5 7.0 1.4 2.9 3 0 0 3 3 2 0 Centrosomin N-terminal motif 1 Glyco_transf_22 PF03901.17 EFE43606.1 - 3.2e-05 23.4 0.5 3.7e-05 23.2 0.5 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF1772 PF08592.11 EFE43606.1 - 0.047 14.0 1.6 0.065 13.6 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) UCH PF00443.29 EFE43607.1 - 8.4e-52 176.2 1.0 8.4e-52 176.2 1.0 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE43607.1 - 6.9e-25 88.3 2.8 3.4e-24 86.0 2.8 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rib_hydrolayse PF02267.17 EFE43608.1 - 0.13 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosyl cyclase Ank_2 PF12796.7 EFE43609.1 - 2.4e-26 92.1 0.1 6.6e-11 42.7 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFE43609.1 - 1.1e-21 76.6 2.7 1.5e-06 28.4 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFE43609.1 - 1.7e-17 63.5 0.3 1.2e-05 25.7 0.0 3.8 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE43609.1 - 9.8e-14 50.1 3.6 6.7e-05 23.0 0.1 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFE43609.1 - 4.8e-09 36.3 3.6 0.00041 20.7 0.1 4.8 5 0 0 5 5 5 2 Ankyrin repeat SMC_N PF02463.19 EFE43610.1 - 1.8e-48 164.9 0.0 2.2e-47 161.3 0.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFE43610.1 - 2.3e-30 105.3 1.0 1.4e-29 102.8 0.0 2.9 4 0 0 4 4 4 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EFE43610.1 - 3e-07 31.2 17.4 3e-07 31.2 17.4 6.5 2 2 2 5 5 5 1 AAA domain AAA_21 PF13304.6 EFE43610.1 - 1.3e-06 28.4 19.3 3.3e-06 27.1 1.7 3.9 3 2 3 6 6 6 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFE43610.1 - 0.00033 20.3 0.0 0.00077 19.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain CALCOCO1 PF07888.11 EFE43610.1 - 0.0013 17.7 3.3 0.0013 17.7 3.3 5.2 3 2 1 5 5 5 2 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4200 PF13863.6 EFE43610.1 - 0.0039 17.6 5.6 0.0039 17.6 5.6 9.0 4 3 4 9 9 9 4 Domain of unknown function (DUF4200) SbcCD_C PF13558.6 EFE43610.1 - 0.0055 16.9 0.0 0.032 14.5 0.0 2.4 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF1664 PF07889.12 EFE43610.1 - 0.081 13.0 60.3 1.4 9.0 5.4 8.9 4 3 6 11 11 11 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EFE43610.1 - 1.4 9.4 35.8 4.9 7.7 1.8 8.4 7 1 1 8 8 8 0 Nucleopolyhedrovirus P10 protein LEAP-2 PF07359.11 EFE43611.1 - 0.07 13.0 0.5 0.33 10.8 0.0 2.0 1 1 1 2 2 2 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) acVLRF1 PF18859.1 EFE43611.1 - 0.076 13.3 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Actinobacteria/chloroflexi VLRF1 release factor E3_binding PF02817.17 EFE43612.1 - 4.1e-13 49.4 0.1 3.8e-11 43.1 0.0 2.5 2 0 0 2 2 2 1 e3 binding domain NAD_Gly3P_dh_C PF07479.14 EFE43612.1 - 0.081 13.2 0.0 0.19 12.0 0.0 1.6 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus PPK2 PF03976.14 EFE43612.1 - 0.13 11.7 0.0 4.6 6.7 0.0 2.1 1 1 1 2 2 2 0 Polyphosphate kinase 2 (PPK2) Abhydrolase_2 PF02230.16 EFE43614.1 - 5e-26 91.9 0.0 1.7e-15 57.4 0.0 3.2 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EFE43614.1 - 0.00049 20.8 1.8 0.0007 20.3 1.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFE43614.1 - 0.00066 19.2 0.0 0.0023 17.5 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family Sulphotransf PF09037.10 EFE43614.1 - 0.032 13.8 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 Stf0 sulphotransferase HNH_2 PF13391.6 EFE43615.1 - 1.3e-14 54.1 0.0 2.6e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease WD40 PF00400.32 EFE43616.1 - 3e-22 78.5 9.1 0.00013 22.6 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE43616.1 - 2.2e-09 37.5 6.1 0.0051 17.1 0.2 4.8 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFE43616.1 - 4.5e-06 26.7 0.1 0.0079 16.1 0.1 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFE43616.1 - 0.033 13.2 0.0 0.071 12.1 0.0 1.5 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Peptidase_M18 PF02127.15 EFE43618.1 - 1.9e-141 471.8 0.0 2.3e-141 471.5 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Sugar_tr PF00083.24 EFE43619.1 - 2.5e-46 158.5 11.1 3.9e-46 157.9 11.1 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE43619.1 - 4.2e-37 127.9 31.9 1.8e-25 89.6 14.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EFE43619.1 - 7.1e-05 21.3 2.6 7.1e-05 21.3 2.6 2.2 3 0 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family Flu_PB1 PF00602.17 EFE43619.1 - 0.022 12.9 0.0 0.031 12.4 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 Sigma70_r4 PF04545.16 EFE43619.1 - 0.086 12.4 0.2 9.1 5.9 0.0 2.7 2 0 0 2 2 2 0 Sigma-70, region 4 Hydrolase_6 PF13344.6 EFE43620.1 - 1.9e-18 66.4 0.0 3.4e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE43620.1 - 5.7e-17 61.6 0.1 4.2e-16 58.8 0.1 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EFE43620.1 - 5.6e-07 30.1 0.0 0.00014 22.2 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFE43620.1 - 9.6e-05 22.5 0.0 0.09 12.9 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase UPF0253 PF06786.12 EFE43620.1 - 0.042 14.1 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0253) Mhr1 PF12829.7 EFE43621.1 - 0.13 12.4 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination DUF1746 PF08508.10 EFE43622.1 - 1.5e-22 80.1 5.5 3e-20 72.7 0.1 2.2 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1746) CLP_protease PF00574.23 EFE43623.1 - 2e-43 148.4 0.1 2.3e-43 148.2 0.1 1.0 1 0 0 1 1 1 1 Clp protease DHDPS PF00701.22 EFE43623.1 - 0.0021 16.8 0.0 0.0027 16.5 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Tugs PF17840.1 EFE43623.1 - 0.19 12.0 0.6 0.29 11.3 0.6 1.3 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain Rep_fac_C PF08542.11 EFE43624.1 - 1.8e-22 79.5 0.1 7.6e-22 77.5 0.1 2.1 2 1 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 EFE43624.1 - 2.5e-12 47.3 0.0 7.6e-12 45.8 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EFE43624.1 - 2.8e-09 37.0 0.0 2.7e-07 30.5 0.0 2.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 EFE43624.1 - 3e-05 24.2 0.3 0.0001 22.5 0.1 2.0 2 0 0 2 2 2 1 AAA C-terminal domain AAA_11 PF13086.6 EFE43624.1 - 0.0035 17.2 0.0 0.005 16.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFE43624.1 - 0.006 16.3 0.0 0.02 14.6 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFE43624.1 - 0.012 15.8 0.5 0.5 10.6 0.1 3.0 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EFE43624.1 - 0.053 12.9 0.0 2.5 7.4 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EFE43624.1 - 0.061 13.7 0.1 0.43 10.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EFE43624.1 - 0.062 12.5 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EFE43624.1 - 0.064 13.6 0.5 1.1 9.7 0.1 2.5 2 1 1 3 3 3 0 AAA ATPase domain AAA_5 PF07728.14 EFE43624.1 - 0.19 11.7 0.4 3.5 7.6 0.2 2.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) MFS_1 PF07690.16 EFE43625.1 - 6e-41 140.5 49.4 6e-41 140.5 49.4 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE43625.1 - 3.5e-11 42.3 15.2 3.5e-11 42.3 15.2 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFE43625.1 - 2.8e-10 39.7 29.5 3.5e-09 36.1 15.3 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter DUF3522 PF12036.8 EFE43625.1 - 0.0012 19.2 1.4 0.0071 16.6 0.1 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3522) YpmT PF17431.2 EFE43625.1 - 0.4 10.8 1.6 0.88 9.7 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized YmpT-like Sec20 PF03908.13 EFE43626.1 - 6.5e-16 58.0 2.4 1.8e-15 56.6 2.4 1.8 1 0 0 1 1 1 1 Sec20 CUT PF02376.15 EFE43626.1 - 0.5 10.6 3.2 2.4 8.4 3.2 2.1 1 1 0 1 1 1 0 CUT domain Pyrophosphatase PF00719.19 EFE43627.1 - 6.7e-53 178.8 0.1 9.8e-53 178.2 0.1 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase Dus PF01207.17 EFE43628.1 - 5.2e-42 144.0 0.0 1.5e-41 142.5 0.0 1.8 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) TFIIF_alpha PF05793.12 EFE43628.1 - 0.058 12.0 14.7 0.082 11.5 14.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 EFE43628.1 - 0.16 10.3 16.2 0.22 9.8 16.2 1.1 1 0 0 1 1 1 0 CDC45-like protein BSP_II PF05432.11 EFE43628.1 - 1.5 8.5 20.9 2.4 7.8 20.9 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF2052 PF09747.9 EFE43628.1 - 3.6 7.7 19.3 5.7 7.0 19.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PRP38_assoc PF12871.7 EFE43628.1 - 4 8.1 23.1 7.2 7.3 23.1 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Nop14 PF04147.12 EFE43628.1 - 5.6 5.0 16.0 7.6 4.6 16.0 1.1 1 0 0 1 1 1 0 Nop14-like family Peptidase_M28 PF04389.17 EFE43629.1 - 1.8e-43 148.5 0.4 4.3e-43 147.3 0.1 1.7 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 EFE43629.1 - 2.3e-13 50.0 0.3 6.1e-13 48.6 0.3 1.8 1 0 0 1 1 1 1 PA domain Peptidase_M42 PF05343.14 EFE43629.1 - 0.0054 15.8 0.0 0.2 10.6 0.0 2.5 3 0 0 3 3 3 1 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.28 EFE43629.1 - 0.0088 15.8 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 SNF2_N PF00176.23 EFE43630.1 - 1.5e-51 175.2 0.1 2.3e-51 174.6 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE43630.1 - 1.4e-19 70.5 0.4 2.1e-18 66.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE43630.1 - 2.3e-08 34.3 0.0 5.1e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFE43630.1 - 2.4e-06 26.9 0.1 4.7e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 EFE43630.1 - 2.3e-05 24.2 0.0 4.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Phage_Gp23 PF10669.9 EFE43633.1 - 0.014 15.8 2.6 0.018 15.4 2.6 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) MTBP_N PF14918.6 EFE43633.1 - 0.017 14.6 0.3 0.02 14.3 0.3 1.0 1 0 0 1 1 1 0 MDM2-binding OAD_gamma PF04277.13 EFE43633.1 - 0.035 14.7 0.1 0.043 14.4 0.1 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain SR-25 PF10500.9 EFE43633.1 - 0.11 12.1 9.8 0.15 11.6 9.8 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein LapA_dom PF06305.11 EFE43633.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain TRAM_LAG1_CLN8 PF03798.16 EFE43634.1 - 2.2e-36 125.5 15.3 4e-36 124.6 15.3 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EFE43634.1 - 2e-23 81.8 0.1 5e-23 80.5 0.1 1.7 1 0 0 1 1 1 1 TRAM1-like protein MIP PF00230.20 EFE43634.1 - 0.08 12.6 0.6 0.12 12.1 0.6 1.3 1 0 0 1 1 1 0 Major intrinsic protein T_cell_tran_alt PF15128.6 EFE43634.1 - 0.76 9.6 3.5 0.59 10.0 0.7 2.1 2 0 0 2 2 2 0 T-cell leukemia translocation-altered Hira PF07569.11 EFE43635.1 - 1.2e-79 267.1 0.0 2.4e-79 266.2 0.0 1.5 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 EFE43635.1 - 7.7e-18 64.5 20.8 0.00011 22.9 0.0 8.5 7 1 1 8 8 8 5 WD domain, G-beta repeat HIRA_B PF09453.10 EFE43635.1 - 1.6e-10 40.6 0.1 3.7e-10 39.4 0.1 1.7 1 0 0 1 1 1 1 HIRA B motif ANAPC4_WD40 PF12894.7 EFE43635.1 - 1.9e-09 37.7 0.0 0.089 13.1 0.0 4.7 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EFE43635.1 - 5.1e-05 23.1 5.3 0.72 9.9 0.0 5.4 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Alg14 PF08660.11 EFE43635.1 - 0.18 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like YchF-GTPase_C PF06071.13 EFE43636.1 - 2.4e-33 114.1 0.1 5.1e-33 113.1 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EFE43636.1 - 5e-17 62.0 0.0 1.1e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFE43636.1 - 0.00076 19.0 0.0 0.0016 18.0 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 EFE43636.1 - 0.014 15.4 0.1 0.052 13.6 0.1 2.0 1 1 0 1 1 1 0 TGS domain AAA_14 PF13173.6 EFE43636.1 - 0.17 11.9 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PUA PF01472.20 EFE43637.1 - 5.4e-14 51.9 0.3 7e-14 51.6 0.3 1.2 1 0 0 1 1 1 1 PUA domain Pre-PUA PF17832.1 EFE43637.1 - 2.1e-06 28.3 0.0 3.2e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain DUF1947 PF09183.10 EFE43637.1 - 0.15 12.4 0.0 0.31 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) RIC1 PF07064.13 EFE43638.1 - 1.1e-78 264.2 0.0 1.7e-78 263.5 0.0 1.3 1 0 0 1 1 1 1 RIC1 SGTA_dimer PF16546.5 EFE43639.1 - 7.6e-24 83.3 0.5 1.5e-23 82.3 0.1 1.7 2 0 0 2 2 2 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 EFE43639.1 - 4.5e-13 48.4 4.6 1.1e-05 25.1 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFE43639.1 - 4.6e-13 48.2 6.5 0.00014 21.7 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFE43639.1 - 8.2e-11 41.4 4.1 1.9e-07 30.6 0.6 2.8 1 1 2 3 3 3 2 TPR repeat TPR_16 PF13432.6 EFE43639.1 - 3.4e-09 37.2 19.4 5.6e-07 30.1 4.2 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFE43639.1 - 6.2e-06 26.2 0.9 0.012 16.0 0.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFE43639.1 - 1.1e-05 25.3 3.9 0.54 10.6 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFE43639.1 - 1.3e-05 25.4 2.7 9.3e-05 22.7 0.6 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFE43639.1 - 2.7e-05 23.9 0.3 1.6 9.0 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFE43639.1 - 5e-05 23.4 2.3 0.00054 20.1 0.5 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFE43639.1 - 5e-05 23.8 6.8 0.11 13.4 1.2 3.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFE43639.1 - 0.00037 21.0 1.7 0.0036 17.8 0.5 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFE43639.1 - 0.00065 19.5 0.7 0.12 12.3 0.4 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat XPC-binding PF09280.11 EFE43639.1 - 0.00065 19.4 3.1 0.0021 17.7 3.1 1.8 2 0 0 2 2 2 1 XPC-binding domain STI1 PF17830.1 EFE43639.1 - 0.00085 19.2 11.5 0.0078 16.1 6.1 2.8 3 0 0 3 3 3 1 STI1 domain TPR_15 PF13429.6 EFE43639.1 - 0.074 12.3 0.2 0.12 11.5 0.2 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat GerD PF17898.1 EFE43639.1 - 0.18 11.8 1.4 0.73 9.8 0.5 2.3 2 0 0 2 2 2 0 Spore germination GerD central core domain DUF4264 PF14084.6 EFE43639.1 - 0.22 11.2 0.0 0.48 10.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) TPR_6 PF13174.6 EFE43639.1 - 0.5 11.1 5.3 16 6.4 0.3 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Tim44 PF04280.15 EFE43640.1 - 1.7e-37 128.7 0.0 4.3e-37 127.5 0.0 1.7 2 0 0 2 2 2 1 Tim44-like domain Spt20 PF12090.8 EFE43640.1 - 0.41 10.2 6.5 0.66 9.5 6.5 1.4 1 0 0 1 1 1 0 Spt20 family TRAP_alpha PF03896.16 EFE43640.1 - 4.4 6.4 6.6 1.8 7.7 2.2 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Ribosomal_S11 PF00411.19 EFE43641.1 - 2.3e-05 24.8 0.0 5.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S11 VPS9 PF02204.18 EFE43642.1 - 2.5e-18 66.2 0.1 6.5e-18 64.9 0.1 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 EFE43642.1 - 1.3e-15 57.2 0.2 2.1e-13 50.2 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFE43642.1 - 8.5e-12 45.5 0.0 0.0021 18.6 0.0 3.9 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) PX PF00787.24 EFE43642.1 - 6.4e-05 22.9 0.5 0.00019 21.4 0.5 1.8 1 0 0 1 1 1 1 PX domain Ank_4 PF13637.6 EFE43642.1 - 0.0001 22.8 0.3 0.35 11.5 0.0 5.1 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE43642.1 - 0.00031 20.9 0.2 0.62 10.8 0.0 5.1 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 EFE43642.1 - 0.021 15.2 0.2 11 6.7 0.0 4.0 4 0 0 4 4 4 0 Ankyrin repeat Inhibitor_I78 PF11720.8 EFE43644.1 - 9.7e-13 48.0 0.0 1.5e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 EFE43644.1 - 9.7e-05 23.0 0.0 0.00016 22.3 0.0 1.4 1 0 0 1 1 1 1 Potato inhibitor I family Nefa_Nip30_N PF10187.9 EFE43645.1 - 2.9e-31 107.9 11.2 2.9e-31 107.9 11.2 1.8 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF572 PF04502.13 EFE43645.1 - 0.0023 17.6 12.8 0.0029 17.3 12.8 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) CsgA PF17334.2 EFE43645.1 - 0.12 13.1 3.4 0.49 11.2 3.4 1.9 1 1 0 1 1 1 0 Minor curli fiber component A DUF2570 PF10828.8 EFE43645.1 - 0.5 10.2 3.6 0.88 9.4 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) CK_II_beta PF01214.18 EFE43647.1 - 1.2e-73 246.9 0.1 2e-73 246.1 0.1 1.4 1 0 0 1 1 1 1 Casein kinase II regulatory subunit RNA_pol_3_Rpc31 PF11705.8 EFE43647.1 - 0.0043 17.4 6.0 0.0063 16.8 6.0 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 zf-B_box PF00643.24 EFE43647.1 - 0.5 10.6 1.9 0.72 10.1 0.4 1.9 2 0 0 2 2 2 0 B-box zinc finger CDC45 PF02724.14 EFE43647.1 - 6.2 5.0 6.8 8.9 4.5 6.8 1.2 1 0 0 1 1 1 0 CDC45-like protein E1-E2_ATPase PF00122.20 EFE43648.1 - 2e-45 154.6 1.7 2e-45 154.6 1.7 2.6 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EFE43648.1 - 2.7e-21 76.8 0.1 7.4e-21 75.4 0.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EFE43648.1 - 1.2e-10 41.6 0.0 5.3e-10 39.6 0.0 2.1 2 0 0 2 2 2 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 EFE43648.1 - 0.00086 19.1 0.1 1 9.1 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase CoA_binding_2 PF13380.6 EFE43648.1 - 0.0026 18.3 0.0 0.0073 16.8 0.0 1.8 1 0 0 1 1 1 1 CoA binding domain Fungal_trans_2 PF11951.8 EFE43650.1 - 2.1e-57 194.7 9.3 3.3e-57 194.1 9.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE43650.1 - 6.6e-08 32.5 9.9 1.4e-07 31.5 9.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_3 PF07859.13 EFE43651.1 - 2.6e-06 27.5 0.5 5.8e-06 26.3 0.5 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE43651.1 - 0.0013 19.4 2.5 0.0016 19.1 2.5 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 EFE43651.1 - 0.039 14.1 0.0 0.054 13.6 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Chlorophyllase2 PF12740.7 EFE43651.1 - 0.059 12.3 0.0 0.087 11.7 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF2974 PF11187.8 EFE43651.1 - 0.19 11.3 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) JAB PF01398.21 EFE43652.1 - 6.5e-06 26.1 0.3 0.00044 20.2 0.3 2.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Trypan_PARP PF05887.11 EFE43653.1 - 0.0044 17.0 22.1 0.0044 17.0 22.1 17.4 7 3 9 17 17 17 3 Procyclic acidic repetitive protein (PARP) DUF737 PF05300.11 EFE43653.1 - 0.0068 16.8 5.0 0.0068 16.8 5.0 11.2 3 2 3 6 6 6 1 Protein of unknown function (DUF737) HMG_box_2 PF09011.10 EFE43654.1 - 2.3e-06 28.1 3.0 2.3e-06 28.1 3.0 2.5 3 0 0 3 3 3 1 HMG-box domain HMG_box PF00505.19 EFE43654.1 - 3.4e-06 27.4 4.5 3.4e-06 27.4 4.5 2.9 4 1 0 4 4 4 1 HMG (high mobility group) box Protamine_like PF06382.11 EFE43654.1 - 0.0029 17.8 0.6 0.0029 17.8 0.6 2.2 2 0 0 2 2 2 1 Protamine and protamine like PPL5 PF18168.1 EFE43654.1 - 3.4 6.9 5.9 0.39 10.0 0.5 2.0 2 0 0 2 2 2 0 Prim-pol family 5 DEAD PF00270.29 EFE43655.1 - 2.5e-49 167.4 0.0 9.8e-49 165.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE43655.1 - 1.2e-26 93.2 0.0 4.7e-26 91.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE43655.1 - 0.003 17.6 0.0 0.021 14.8 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C2H2 PF00096.26 EFE43656.1 - 2 9.0 0.0 2 9.0 0.0 4.9 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE43656.1 - 5.8 8.0 0.0 5.8 8.0 0.0 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE43658.1 - 2e-06 27.9 12.8 3.7e-05 23.9 3.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE43658.1 - 5.4e-06 26.6 3.2 5.4e-06 26.6 3.2 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE43658.1 - 0.0017 19.0 1.9 0.0017 19.0 1.9 3.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 EFE43658.1 - 0.0018 18.6 0.9 0.0018 18.6 0.9 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EFE43658.1 - 0.014 15.4 1.5 0.014 15.4 1.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFE43658.1 - 0.014 15.7 0.9 0.045 14.1 0.9 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF2225 PF09986.9 EFE43658.1 - 0.025 14.3 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-Di19 PF05605.12 EFE43658.1 - 0.058 13.7 5.6 0.14 12.5 5.6 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding IBR PF01485.21 EFE43658.1 - 0.067 13.4 1.8 0.14 12.4 1.8 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain IMD PF08397.11 EFE43659.1 - 0.028 13.8 2.6 0.032 13.6 2.6 1.1 1 0 0 1 1 1 0 IRSp53/MIM homology domain Podoplanin PF05808.11 EFE43660.1 - 0.097 12.8 5.2 0.21 11.7 5.2 1.7 1 1 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EFE43660.1 - 2.7 7.5 4.1 5.1 6.6 4.1 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain HAT PF02184.16 EFE43661.1 - 7.4e-24 83.4 79.7 2.1e-16 59.6 2.6 13.0 14 0 0 14 14 14 4 HAT (Half-A-TPR) repeat TPR_19 PF14559.6 EFE43661.1 - 2.7e-18 66.2 0.1 5.1e-05 23.7 0.0 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFE43661.1 - 1e-15 57.1 32.0 0.00077 20.1 0.4 11.2 7 2 8 15 15 13 6 Tetratricopeptide repeat Suf PF05843.14 EFE43661.1 - 3e-09 37.3 26.8 0.00037 20.6 4.1 5.6 2 2 2 5 5 5 3 Suppressor of forked protein (Suf) TPR_17 PF13431.6 EFE43661.1 - 2.9e-08 33.5 4.2 0.91 10.1 0.0 6.6 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFE43661.1 - 3.1e-06 26.9 3.8 13 6.3 0.0 8.1 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFE43661.1 - 5.6e-05 23.5 17.1 0.81 10.5 0.0 7.8 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFE43661.1 - 0.00014 21.7 17.3 0.4 10.9 0.0 7.7 11 0 0 11 11 10 2 Tetratricopeptide repeat NRDE-2 PF08424.10 EFE43661.1 - 0.0035 16.5 24.9 0.03 13.5 2.0 5.3 3 2 2 5 5 5 2 NRDE-2, necessary for RNA interference TPR_9 PF13371.6 EFE43661.1 - 0.027 14.6 2.1 4.9 7.4 0.2 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFE43661.1 - 0.036 14.7 14.0 1.4 9.6 0.0 7.0 8 1 1 9 9 9 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EFE43661.1 - 0.057 13.5 28.5 0.067 13.3 2.4 6.7 5 3 2 7 7 7 0 U3 small nucleolar RNA-associated protein 6 ER PF01133.17 EFE43661.1 - 0.35 10.9 2.4 5.2 7.1 0.5 3.7 3 2 1 4 4 4 0 Enhancer of rudimentary TPR_12 PF13424.6 EFE43661.1 - 3.2 8.1 17.8 9.1 6.6 0.1 6.6 6 2 1 7 7 7 0 Tetratricopeptide repeat Nop PF01798.18 EFE43662.1 - 1.3e-71 240.7 0.0 1.9e-71 240.2 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EFE43662.1 - 4.2e-47 160.0 1.4 7.9e-47 159.1 1.4 1.5 1 0 0 1 1 1 1 Prp31 C terminal domain RRN3 PF05327.11 EFE43662.1 - 2 6.9 7.3 2.8 6.4 7.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 AdoHcyase PF05221.17 EFE43664.1 - 7.7e-116 386.4 0.0 1.7e-61 208.0 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EFE43664.1 - 2.3e-84 281.4 2.2 4.7e-84 280.4 2.2 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EFE43664.1 - 3.6e-07 29.7 0.1 7.1e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EFE43664.1 - 9.9e-05 22.0 0.2 0.00017 21.2 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EFE43664.1 - 0.0019 18.4 0.3 0.0043 17.3 0.1 1.7 2 0 0 2 2 2 1 TrkA-N domain DUF3759 PF12585.8 EFE43665.1 - 5.2e-36 122.6 7.2 6.2e-36 122.3 7.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) Band_7 PF01145.25 EFE43667.1 - 3.7e-27 95.5 0.3 3.7e-27 95.5 0.3 1.8 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EFE43667.1 - 2.7e-23 81.8 1.6 2.7e-23 81.8 1.6 2.2 2 0 0 2 2 2 1 C-terminal region of band_7 Pox_A11 PF05061.13 EFE43667.1 - 0.012 15.0 0.3 0.018 14.4 0.3 1.3 1 0 0 1 1 1 0 Poxvirus A11 Protein RecX PF02631.16 EFE43667.1 - 0.027 14.9 1.8 0.077 13.5 0.9 2.2 1 1 1 2 2 2 0 RecX family Band_7_1 PF13421.6 EFE43667.1 - 0.045 13.5 0.0 0.08 12.6 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family GSH-S_N PF02951.14 EFE43667.1 - 0.12 12.5 0.1 0.38 10.9 0.1 1.8 1 1 0 1 1 1 0 Prokaryotic glutathione synthetase, N-terminal domain DNase_NucA_NucB PF14040.6 EFE43669.1 - 0.0057 17.0 1.0 13 6.2 0.1 3.7 1 1 3 4 4 4 2 Deoxyribonuclease NucA/NucB DUF1773 PF08593.10 EFE43669.1 - 0.16 13.0 12.4 14 6.8 0.0 5.1 4 1 0 4 4 4 0 Domain of unknown function PAP2 PF01569.21 EFE43671.1 - 2.7e-25 88.7 1.1 3.8e-25 88.2 0.2 1.7 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EFE43671.1 - 0.0032 17.2 1.7 0.39 10.4 0.0 2.6 2 0 0 2 2 2 2 PAP2 superfamily Peptidase_C14 PF00656.22 EFE43673.1 - 0.00017 21.6 0.0 0.00022 21.3 0.0 1.2 1 0 0 1 1 1 1 Caspase domain Peptidase_C13 PF01650.18 EFE43673.1 - 0.0027 17.3 0.1 0.0039 16.7 0.1 1.1 1 0 0 1 1 1 1 Peptidase C13 family Raptor_N PF14538.6 EFE43673.1 - 0.011 15.7 0.1 0.079 12.9 0.0 2.3 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain Aldo_ket_red PF00248.21 EFE43674.1 - 4.8e-48 163.9 0.1 7.8e-48 163.2 0.1 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family NPR3 PF03666.13 EFE43677.1 - 5.6e-153 510.1 0.0 5.6e-153 510.1 0.0 2.9 3 1 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 VPS38 PF17649.1 EFE43677.1 - 0.045 12.6 0.0 0.12 11.2 0.0 1.7 2 0 0 2 2 2 0 Vacuolar protein sorting 38 ATG22 PF11700.8 EFE43677.1 - 0.094 11.3 0.0 0.23 10.1 0.0 1.5 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like NPR2 PF06218.11 EFE43677.1 - 0.2 10.4 0.0 0.38 9.4 0.0 1.3 1 0 0 1 1 1 0 Nitrogen permease regulator 2 Mago-bind PF09282.10 EFE43677.1 - 1.2 9.1 6.3 3.9 7.4 6.3 1.9 1 0 0 1 1 1 0 Mago binding Hepatitis_core PF00906.20 EFE43677.1 - 2.9 7.4 5.5 3.9 7.0 2.9 2.2 2 0 0 2 2 2 0 Hepatitis core antigen BUD22 PF09073.10 EFE43677.1 - 4.5 6.5 41.4 0.064 12.6 0.8 3.2 3 0 0 3 3 3 0 BUD22 DUF1754 PF08555.10 EFE43678.1 - 0.043 14.6 20.4 0.049 14.4 20.4 1.1 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Cwf_Cwc_15 PF04889.12 EFE43678.1 - 0.088 12.5 19.3 0.11 12.3 19.3 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FCP1_C PF09309.10 EFE43678.1 - 0.87 9.4 17.4 0.97 9.3 17.4 1.0 1 0 0 1 1 1 0 FCP1, C-terminal SR-25 PF10500.9 EFE43678.1 - 1.1 8.8 16.3 1.3 8.6 16.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pox_Ag35 PF03286.14 EFE43678.1 - 2.3 8.0 18.2 3.1 7.5 18.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein BUD22 PF09073.10 EFE43678.1 - 2.8 7.2 22.2 3.1 7.1 22.2 1.0 1 0 0 1 1 1 0 BUD22 Methyltransf_25 PF13649.6 EFE43680.1 - 7.3e-12 45.8 0.0 1.6e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE43680.1 - 2.1e-08 34.1 0.0 5.8e-08 32.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE43680.1 - 1.4e-07 32.1 0.0 1.1e-06 29.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE43680.1 - 2.7e-06 27.9 0.0 6.6e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE43680.1 - 6.9e-06 26.0 0.0 2e-05 24.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE43680.1 - 0.0012 18.3 0.0 0.0022 17.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EFE43680.1 - 0.0027 17.7 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFE43680.1 - 0.0063 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase UPF0020 PF01170.18 EFE43680.1 - 0.047 13.4 0.0 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DREV PF05219.12 EFE43680.1 - 0.15 11.1 0.0 0.3 10.2 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase PCMT PF01135.19 EFE43680.1 - 0.16 11.7 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) EAV_GS PF01309.18 EFE43682.1 - 0.028 14.1 0.2 0.046 13.3 0.2 1.3 1 0 0 1 1 1 0 Equine arteritis virus small envelope glycoprotein SpoIIIAC PF06686.11 EFE43682.1 - 0.12 12.5 0.3 0.12 12.5 0.3 2.3 2 0 0 2 2 2 0 Stage III sporulation protein AC/AD protein family DUF1992 PF09350.10 EFE43683.1 - 8.4e-21 73.9 0.8 2.5e-20 72.4 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1992) RPAP1_N PF08621.10 EFE43683.1 - 0.0044 16.8 0.2 1.4 8.8 0.0 3.2 2 0 0 2 2 2 2 RPAP1-like, N-terminal Nrap_D6 PF17407.2 EFE43683.1 - 0.0095 16.2 1.2 2.6 8.3 0.0 3.5 1 1 1 2 2 2 1 Nrap protein domain 6 DUF2353 PF09789.9 EFE43683.1 - 0.15 11.4 5.7 0.03 13.7 1.1 1.9 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) p450 PF00067.22 EFE43684.1 - 3e-46 158.1 0.0 1.6e-45 155.7 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.7 EFE43685.1 - 5.4e-07 29.4 0.8 1.4e-06 28.1 0.8 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE43685.1 - 4.2e-05 23.3 0.1 0.00011 22.0 0.1 1.6 1 0 0 1 1 1 1 F-box domain Lactonase PF10282.9 EFE43685.1 - 0.17 11.1 0.0 0.44 9.7 0.0 1.6 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller SRP40_C PF05022.12 EFE43686.1 - 2.5e-18 66.7 0.1 1e-17 64.7 0.1 2.1 1 0 0 1 1 1 1 SRP40, C-terminal domain LisH PF08513.11 EFE43686.1 - 0.0049 16.8 0.3 0.11 12.5 0.0 2.5 2 0 0 2 2 2 1 LisH Sec3-PIP2_bind PF15277.6 EFE43687.1 - 2.3e-29 101.4 0.1 4.3e-29 100.5 0.1 1.5 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C PF09763.9 EFE43687.1 - 2.7e-24 85.6 1.7 4.4e-24 84.9 1.7 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec3 DOCK_N PF16172.5 EFE43688.1 - 3.8e-112 374.9 0.0 6.7e-112 374.1 0.0 1.4 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 EFE43688.1 - 1.2e-40 139.4 0.0 5.5e-40 137.3 0.0 2.1 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DHR-2 PF06920.13 EFE43688.1 - 1.5e-39 136.0 4.0 4.6e-39 134.5 4.0 1.7 1 1 0 1 1 1 1 Dock homology region 2 SH3_1 PF00018.28 EFE43688.1 - 4.1e-05 23.1 0.0 0.00011 21.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFE43688.1 - 0.00014 21.6 0.0 0.0017 18.2 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain Glyco_hydro_20 PF00728.22 EFE43689.1 - 3.8e-100 335.7 0.0 4.9e-100 335.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFE43689.1 - 8.8e-25 88.0 0.0 1.1e-23 84.4 0.0 2.3 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFE43689.1 - 0.00028 21.7 0.0 0.00061 20.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 NmrA PF05368.13 EFE43690.1 - 4.7e-17 62.3 0.0 1.4e-09 37.8 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 EFE43690.1 - 1.2e-06 28.5 0.0 2.3e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Saf_2TM PF18303.1 EFE43691.1 - 0.017 14.7 0.1 0.031 13.9 0.1 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Ndc1_Nup PF09531.10 EFE43691.1 - 0.17 10.5 5.5 0.23 10.1 5.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EFE43691.1 - 2.5 6.8 8.2 3.6 6.3 8.2 1.3 1 0 0 1 1 1 0 Presenilin FUSC PF04632.12 EFE43691.1 - 4.6 5.6 4.3 5.7 5.3 4.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family CDC45 PF02724.14 EFE43691.1 - 5.7 5.1 16.1 8 4.6 16.1 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2052 PF09747.9 EFE43692.1 - 0.001 19.3 7.5 0.001 19.3 7.5 1.2 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 EFE43692.1 - 0.0015 18.0 7.8 0.0015 18.0 7.8 1.0 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 EFE43692.1 - 0.014 14.8 6.2 0.011 15.1 6.2 1.0 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 EFE43692.1 - 0.016 14.0 1.8 0.014 14.2 1.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 IPK PF03770.16 EFE43692.1 - 0.072 12.9 0.0 0.074 12.9 0.0 1.1 1 0 0 1 1 1 0 Inositol polyphosphate kinase DUF4471 PF14740.6 EFE43692.1 - 0.077 12.2 0.8 0.072 12.3 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) SpoIIP PF07454.11 EFE43692.1 - 0.12 11.8 3.7 0.13 11.7 3.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FYDLN_acid PF09538.10 EFE43692.1 - 0.14 12.8 8.7 0.18 12.5 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Presenilin PF01080.17 EFE43692.1 - 0.2 10.4 1.3 0.16 10.7 1.3 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFE43692.1 - 0.45 9.7 1.1 0.36 10.0 1.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter FAM176 PF14851.6 EFE43692.1 - 0.57 9.8 12.2 0.72 9.5 12.2 1.2 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 EFE43692.1 - 0.64 9.8 10.3 0.69 9.7 10.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein BSP_II PF05432.11 EFE43692.1 - 0.64 9.7 20.7 0.72 9.5 20.7 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF3464 PF11947.8 EFE43692.1 - 1.5 8.6 4.3 1.7 8.4 4.3 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PI3K_1B_p101 PF10486.9 EFE43692.1 - 1.6 6.4 7.3 1.8 6.2 7.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Radial_spoke PF04712.12 EFE43692.1 - 2.2 7.1 17.9 2.6 6.9 17.9 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein RPA43_OB PF17875.1 EFE43692.1 - 2.5 8.7 8.3 3.5 8.3 8.3 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I PPL5 PF18168.1 EFE43692.1 - 2.7 7.2 4.4 2.9 7.1 4.4 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DNA_pol_phi PF04931.13 EFE43692.1 - 3.2 5.7 20.1 3.5 5.6 20.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFIIF_alpha PF05793.12 EFE43692.1 - 4.3 5.8 19.5 4.4 5.8 19.5 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Adhes-Ig_like PF09085.10 EFE43692.1 - 4.5 7.4 8.9 9.7 6.4 8.9 1.6 1 1 0 1 1 1 0 Adhesion molecule, immunoglobulin-like Connexin PF00029.19 EFE43692.1 - 4.7 6.9 5.3 5.1 6.8 5.3 1.1 1 0 0 1 1 1 0 Connexin Nop14 PF04147.12 EFE43692.1 - 5.8 5.0 19.2 6 5.0 19.2 1.0 1 0 0 1 1 1 0 Nop14-like family Spore_coat_CotO PF14153.6 EFE43692.1 - 6.1 6.7 13.8 7.3 6.5 13.8 1.1 1 0 0 1 1 1 0 Spore coat protein CotO RPN2_C PF18004.1 EFE43692.1 - 7.5 6.4 14.7 9 6.2 14.7 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain MRNIP PF15749.5 EFE43692.1 - 8.2 7.2 9.6 10 6.9 9.6 1.1 1 0 0 1 1 1 0 MRN-interacting protein Atrophin-1 PF03154.15 EFE43692.1 - 9.1 4.4 8.5 9 4.4 8.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF4746 PF15928.5 EFE43692.1 - 9.4 5.6 18.1 11 5.3 18.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Pkinase PF00069.25 EFE43694.1 - 1.3e-53 182.1 0.0 2.5e-51 174.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43694.1 - 7e-32 110.7 0.0 7.8e-31 107.3 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE43694.1 - 0.0026 17.1 0.0 0.0041 16.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFE43694.1 - 0.0039 16.2 0.1 0.0058 15.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EFE43694.1 - 0.0089 15.1 0.1 0.0089 15.1 0.1 1.8 2 0 0 2 2 2 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EFE43694.1 - 0.1 11.4 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase DUF4805 PF16063.5 EFE43694.1 - 2.1 7.6 6.3 4.1 6.7 6.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) Mem_trans PF03547.18 EFE43695.1 - 7.1e-53 179.4 0.1 8.2e-53 179.2 0.1 1.0 1 0 0 1 1 1 1 Membrane transport protein Choline_kinase PF01633.20 EFE43696.1 - 2.8e-60 203.5 0.0 5.6e-60 202.5 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 EFE43696.1 - 6.9e-17 60.9 0.0 1.5e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 EFE43696.1 - 0.00037 20.5 0.1 0.0011 19.0 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Abhydrolase_2 PF02230.16 EFE43697.1 - 2.6e-22 79.7 0.0 2.3e-17 63.6 0.0 2.1 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 EFE43697.1 - 0.00031 20.5 0.0 0.00063 19.5 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EFE43697.1 - 0.0049 16.4 0.1 0.011 15.2 0.1 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFE43697.1 - 0.026 13.8 0.1 0.15 11.3 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Glyco_hydro_31 PF01055.26 EFE43698.1 - 4.9e-145 484.1 0.0 8.9e-74 249.2 0.2 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EFE43698.1 - 7.3e-27 93.9 0.6 1.8e-26 92.6 0.6 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EFE43698.1 - 1.9e-15 56.9 0.7 5e-15 55.6 0.2 2.1 2 0 0 2 2 2 1 Galactose mutarotase-like FAM176 PF14851.6 EFE43699.1 - 0.45 10.2 3.2 0.24 11.1 0.6 1.9 2 0 0 2 2 2 0 FAM176 family DNA_pol_phi PF04931.13 EFE43699.1 - 1.1 7.3 5.6 10 4.1 6.6 1.9 2 0 0 2 2 2 0 DNA polymerase phi Asp PF00026.23 EFE43700.1 - 1.4e-05 24.7 0.0 2.3e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease EphA2_TM PF14575.6 EFE43700.1 - 0.033 15.1 0.0 0.058 14.3 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Bacteriocin_IIc PF10439.9 EFE43700.1 - 0.042 14.0 0.3 0.11 12.7 0.3 1.7 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide CYYR1 PF10873.8 EFE43700.1 - 0.094 13.2 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Gram_pos_anchor PF00746.21 EFE43700.1 - 0.12 12.3 1.5 0.37 10.8 1.5 1.9 1 0 0 1 1 1 0 LPXTG cell wall anchor motif MFS_1 PF07690.16 EFE43701.1 - 2.3e-18 66.3 39.1 3.4e-12 45.9 22.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE43701.1 - 5e-14 52.0 22.2 3.2e-13 49.4 22.1 2.6 1 1 0 1 1 1 1 Sugar (and other) transporter Glyco_hydro_92 PF07971.12 EFE43702.1 - 9.5e-127 423.7 0.2 1.3e-126 423.3 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EFE43702.1 - 1.3e-46 159.4 3.1 2.2e-46 158.7 3.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain ATP-synt_G PF04718.15 EFE43704.1 - 8.1e-34 116.5 0.1 3.3e-33 114.5 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit ADH_zinc_N PF00107.26 EFE43705.1 - 3.3e-18 65.9 0.0 7.4e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFE43705.1 - 1.8e-16 61.4 0.0 3.9e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE43705.1 - 8.4e-07 28.9 0.0 5.2e-06 26.3 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_1 PF00561.20 EFE43706.1 - 3.4e-14 53.1 0.0 1.2e-11 44.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE43706.1 - 0.023 13.9 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PAP_central PF04928.17 EFE43707.1 - 7.6e-99 329.7 0.0 1.7e-96 322.0 0.0 2.6 1 1 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EFE43707.1 - 1.5e-58 197.3 0.0 2.1e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EFE43707.1 - 0.00087 19.5 0.0 0.002 18.4 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EFE43707.1 - 0.11 12.3 0.1 0.27 11.0 0.1 1.7 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Glyco_transf_20 PF00982.21 EFE43708.1 - 1.1e-164 548.6 0.0 3e-163 543.9 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.6 EFE43708.1 - 0.00068 20.1 0.0 0.0015 19.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EFE43708.1 - 0.0012 18.4 0.2 0.0037 16.8 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 EFE43708.1 - 0.0095 15.6 0.2 0.016 14.9 0.2 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain adh_short_C2 PF13561.6 EFE43709.1 - 8.1e-43 146.6 2.9 1e-42 146.3 2.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE43709.1 - 2.2e-39 134.9 0.7 2.6e-39 134.7 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE43709.1 - 4.3e-11 43.1 0.3 6.7e-11 42.4 0.3 1.3 1 0 0 1 1 1 1 KR domain DUF429 PF04250.13 EFE43709.1 - 0.041 13.7 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF429) Amidase PF01425.21 EFE43710.1 - 9.5e-89 298.4 0.0 1.2e-88 298.1 0.0 1.1 1 0 0 1 1 1 1 Amidase Cation_efflux PF01545.21 EFE43711.1 - 1e-13 51.5 9.1 1.2e-13 51.2 9.1 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFE43711.1 - 1.2e-10 41.3 0.2 2.9e-10 40.1 0.2 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter FlgN PF05130.12 EFE43711.1 - 0.15 12.6 2.1 0.31 11.6 2.1 1.4 1 0 0 1 1 1 0 FlgN protein Sulfotransfer_4 PF17784.1 EFE43712.1 - 3.2e-56 190.6 0.0 3.7e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EFE43712.1 - 0.005 17.3 0.2 0.4 11.0 0.2 2.5 2 1 0 2 2 2 1 Sulfotransferase family Methyltransf_25 PF13649.6 EFE43713.1 - 2.6e-09 37.7 0.0 5.9e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE43713.1 - 1.9e-07 31.8 0.0 3.4e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE43713.1 - 2.4e-05 24.3 0.0 0.00021 21.2 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE43713.1 - 0.00011 22.0 0.0 0.00028 20.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE43713.1 - 0.00099 18.5 0.0 0.002 17.5 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EFE43713.1 - 0.00099 19.7 0.0 0.0058 17.3 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_20 PF12147.8 EFE43713.1 - 0.017 14.3 0.0 0.087 12.0 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase BTRD1 PF17660.1 EFE43714.1 - 3.9e-59 196.3 16.1 6e-15 54.8 0.1 5.1 5 0 0 5 5 5 5 Bacterial tandem repeat domain 1 rve_2 PF13333.6 EFE43714.1 - 0.0017 18.5 1.7 0.057 13.6 0.1 3.3 3 0 0 3 3 3 1 Integrase core domain UvrA_inter PF17760.1 EFE43714.1 - 0.017 15.2 0.8 15 5.7 0.0 3.7 3 1 1 4 4 4 0 UvrA interaction domain Orai-1 PF07856.12 EFE43714.1 - 0.062 13.0 0.0 0.091 12.4 0.0 1.2 1 0 0 1 1 1 0 Mediator of CRAC channel activity 2_5_RNA_ligase2 PF13563.6 EFE43715.1 - 5.3e-32 110.8 0.0 1.2e-31 109.7 0.0 1.5 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily PAP_central PF04928.17 EFE43715.1 - 1.1e-20 73.6 0.0 2e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase central domain MJ1316 PF04457.12 EFE43715.1 - 1.9e-18 67.0 0.3 4.5e-18 65.8 0.3 1.7 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Exo_endo_phos PF03372.23 EFE43715.1 - 1.2e-06 28.2 0.1 4.2e-06 26.5 0.1 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NTP_transf_2 PF01909.23 EFE43715.1 - 0.00062 20.0 0.0 0.0024 18.1 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain UTRA PF07702.13 EFE43716.1 - 0.19 11.6 0.0 0.43 10.4 0.0 1.5 1 0 0 1 1 1 0 UTRA domain Aminotran_1_2 PF00155.21 EFE43718.1 - 5.1e-15 55.5 0.0 1.2e-14 54.3 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Pectate_lyase_3 PF12708.7 EFE43719.1 - 1.9e-101 338.4 13.0 3.1e-86 288.7 6.2 2.7 3 0 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EFE43719.1 - 1.3e-06 28.0 5.4 0.00095 18.8 0.2 3.0 3 0 0 3 3 3 2 N terminal extension of bacteriophage endosialidase Presenilin PF01080.17 EFE43721.1 - 1.4 7.6 2.2 1.4 7.6 2.2 1.1 1 0 0 1 1 1 0 Presenilin Fungal_trans_2 PF11951.8 EFE43722.1 - 8.1e-08 31.5 0.0 2.7e-05 23.2 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain SPX PF03105.19 EFE43722.1 - 0.18 11.7 0.3 0.26 11.2 0.3 1.3 1 0 0 1 1 1 0 SPX domain Pyr_redox_2 PF07992.14 EFE43725.1 - 7.2e-39 133.8 0.0 2.3e-35 122.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE43725.1 - 2.2e-12 47.3 0.0 3.8e-09 37.0 0.0 3.4 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFE43725.1 - 0.0093 16.0 0.2 0.21 11.6 0.0 3.0 3 1 0 3 3 3 1 FAD-NAD(P)-binding GAT PF03127.14 EFE43726.1 - 2.7e-20 72.4 1.0 3.9e-20 71.9 0.2 1.7 2 0 0 2 2 2 1 GAT domain VHS PF00790.19 EFE43726.1 - 0.18 11.7 0.3 0.58 10.0 0.0 2.0 3 0 0 3 3 3 0 VHS domain Ferric_reduct PF01794.19 EFE43727.1 - 9.7e-27 93.6 10.4 9.7e-27 93.6 10.4 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFE43727.1 - 4.4e-16 59.4 0.1 1.2e-13 51.4 0.0 2.7 2 1 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFE43727.1 - 4.5e-11 42.8 0.0 3.1e-06 27.2 0.0 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 EFE43727.1 - 0.06 14.0 0.0 0.21 12.2 0.0 2.0 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain DUF2374 PF09574.10 EFE43727.1 - 3.2 7.6 5.5 3.2 7.7 1.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (Duf2374) Cyt-b5 PF00173.28 EFE43728.1 - 4.9e-10 39.4 0.0 1.1e-09 38.2 0.0 1.7 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ribosomal_S25 PF03297.15 EFE43729.1 - 1.7e-27 95.6 1.3 2.2e-27 95.2 1.3 1.0 1 0 0 1 1 1 1 S25 ribosomal protein TrmB PF01978.19 EFE43729.1 - 0.0016 18.3 0.2 0.0019 18.1 0.2 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_DeoR PF08220.12 EFE43729.1 - 0.0034 17.1 0.1 0.0049 16.6 0.1 1.3 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 EFE43729.1 - 0.013 15.8 0.1 0.019 15.3 0.1 1.4 1 1 0 1 1 1 0 Transcriptional regulator HTH_11 PF08279.12 EFE43729.1 - 0.017 15.0 0.1 0.025 14.5 0.1 1.3 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.6 EFE43729.1 - 0.033 13.7 0.1 0.05 13.2 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 EFE43729.1 - 0.066 13.1 0.0 0.082 12.8 0.0 1.2 1 0 0 1 1 1 0 MarR family ANAPC4_WD40 PF12894.7 EFE43730.1 - 3.1e-08 33.8 0.6 0.00063 20.0 0.0 4.1 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFE43730.1 - 1.4e-06 28.9 6.4 0.0069 17.2 0.1 4.9 4 1 0 4 4 4 2 WD domain, G-beta repeat IKI3 PF04762.12 EFE43730.1 - 1.7e-05 23.1 0.0 2.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 IKI3 family eIF2A PF08662.11 EFE43730.1 - 9.9e-05 22.3 0.1 0.26 11.2 0.0 3.1 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EFE43730.1 - 0.0072 16.2 0.7 1.2 9.2 0.1 3.6 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 EFE43730.1 - 0.18 10.6 0.3 1.8 7.2 0.1 2.3 1 1 1 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region 2OG-FeII_Oxy_3 PF13640.6 EFE43731.1 - 5.6e-08 33.6 0.0 1.1e-07 32.6 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ABC_tran PF00005.27 EFE43732.1 - 1.2e-42 145.7 4.4 8.2e-22 78.2 0.0 3.7 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 EFE43732.1 - 2.2e-13 50.7 5.6 0.0036 17.1 0.0 4.2 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFE43732.1 - 4.6e-10 39.3 1.6 0.0083 15.6 0.5 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_tran_Xtn PF12848.7 EFE43732.1 - 1.9e-08 34.2 1.9 1.9e-08 34.2 1.9 2.0 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 EFE43732.1 - 1.7e-07 31.9 7.7 1.3e-05 25.8 0.2 2.9 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EFE43732.1 - 2.3e-06 27.7 0.2 0.18 11.9 0.0 3.4 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EFE43732.1 - 2.9e-06 26.9 0.4 0.011 15.5 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFE43732.1 - 0.00016 22.0 0.3 0.18 12.1 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EFE43732.1 - 0.00017 21.9 0.9 0.16 12.2 0.2 3.4 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 EFE43732.1 - 0.0016 18.4 0.1 2.3 8.1 0.0 2.9 2 0 0 2 2 2 2 NACHT domain RsgA_GTPase PF03193.16 EFE43732.1 - 0.0018 18.2 1.7 1.2 9.0 0.1 2.9 3 0 0 3 3 2 2 RsgA GTPase AAA_30 PF13604.6 EFE43732.1 - 0.0026 17.5 0.1 1.8 8.2 0.0 3.3 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EFE43732.1 - 0.0044 17.6 0.1 3.9 8.0 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFE43732.1 - 0.0074 16.7 0.1 1.7 9.1 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFE43732.1 - 0.018 15.4 0.0 4.1 7.8 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 EFE43732.1 - 0.025 14.6 0.2 9.9 6.2 0.1 3.4 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 EFE43732.1 - 0.028 13.4 1.3 4 6.3 0.1 2.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 EFE43732.1 - 0.031 14.4 12.5 2.9 7.9 0.0 4.1 4 0 0 4 4 4 0 Helicase HerA, central domain NB-ARC PF00931.22 EFE43732.1 - 0.032 13.4 0.1 7.2 5.7 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain DUF815 PF05673.13 EFE43732.1 - 0.037 13.2 0.2 1.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_15 PF13175.6 EFE43732.1 - 0.038 13.7 11.4 1.1 8.9 0.0 3.8 3 1 1 4 4 4 0 AAA ATPase domain AAA_27 PF13514.6 EFE43732.1 - 0.04 13.5 4.3 0.056 13.0 0.0 2.8 4 0 0 4 4 3 0 AAA domain AAA_5 PF07728.14 EFE43732.1 - 0.046 13.7 1.1 1.2 9.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 EFE43732.1 - 0.048 13.0 0.6 0.55 9.5 0.0 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family Viral_helicase1 PF01443.18 EFE43732.1 - 0.057 13.2 0.1 4.2 7.0 0.0 3.4 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 EFE43732.1 - 0.063 13.4 5.0 3.4 7.8 0.1 3.3 3 1 0 3 3 3 0 AAA domain cobW PF02492.19 EFE43732.1 - 0.083 12.5 1.2 2.9 7.4 0.0 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EFE43732.1 - 0.086 13.2 7.1 5.9 7.2 4.2 3.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 EFE43732.1 - 0.098 12.2 0.1 3.2 7.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_13 PF13166.6 EFE43732.1 - 2.6 6.6 7.8 12 4.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain AA_permease PF00324.21 EFE43733.1 - 2.2e-137 458.6 36.5 2.2e-137 458.6 36.5 1.5 2 0 0 2 2 2 1 Amino acid permease AA_permease_2 PF13520.6 EFE43733.1 - 6.8e-34 117.4 38.7 8.8e-34 117.1 38.7 1.1 1 0 0 1 1 1 1 Amino acid permease MoaC PF01967.21 EFE43734.1 - 1.2e-43 148.5 0.2 1.9e-43 147.8 0.2 1.4 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.13 EFE43734.1 - 1.3e-36 125.3 0.0 1.2e-35 122.2 0.0 2.2 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 EFE43734.1 - 4.5e-29 102.0 0.1 9.8e-29 100.9 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EFE43734.1 - 8.5e-05 22.8 0.0 0.00019 21.7 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Piwi PF02171.17 EFE43735.1 - 3.7e-41 141.3 0.0 6.4e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EFE43735.1 - 4e-18 66.4 0.9 1.3e-17 64.7 0.7 2.0 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EFE43735.1 - 1.6e-15 56.5 0.0 4.1e-15 55.2 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain PAZ PF02170.22 EFE43735.1 - 4.5e-08 33.0 0.0 3.6e-07 30.1 0.0 2.5 2 0 0 2 2 2 1 PAZ domain ArgoL2 PF16488.5 EFE43735.1 - 4.5e-07 30.1 0.1 1.4e-06 28.5 0.1 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain Noc2 PF03715.13 EFE43736.1 - 2e-128 427.8 0.1 7.8e-128 425.9 0.0 2.0 2 0 0 2 2 2 1 Noc2p family Nop14 PF04147.12 EFE43736.1 - 0.00037 18.9 0.2 0.00037 18.9 0.2 3.1 2 1 1 3 3 3 2 Nop14-like family bMG10 PF17973.1 EFE43736.1 - 0.035 14.3 1.1 0.075 13.2 1.1 1.5 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG10 domain VPS28 PF03997.12 EFE43737.1 - 5.5e-74 247.9 0.9 6.7e-74 247.7 0.9 1.1 1 0 0 1 1 1 1 VPS28 protein Fungal_trans_2 PF11951.8 EFE43738.1 - 3.9e-07 29.2 1.4 1.1e-05 24.5 0.2 2.5 2 1 0 2 2 2 2 Fungal specific transcription factor domain APH PF01636.23 EFE43739.1 - 2.6e-18 66.8 0.0 3.3e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFE43739.1 - 0.00047 19.8 0.0 0.49 10.0 0.1 2.2 2 0 0 2 2 2 2 RIO1 family Choline_kinase PF01633.20 EFE43739.1 - 0.0029 17.2 0.0 0.0056 16.3 0.0 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EFE43739.1 - 0.034 13.5 0.0 0.59 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain Fructosamin_kin PF03881.14 EFE43739.1 - 0.042 13.1 0.0 0.062 12.5 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase Methyltransf_16 PF10294.9 EFE43740.1 - 7e-23 81.2 0.0 9.3e-23 80.8 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFE43740.1 - 0.00087 19.2 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EFE43740.1 - 0.08 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) ABC_membrane PF00664.23 EFE43741.1 - 1.2e-33 117.0 30.0 1.4e-30 106.9 14.0 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE43741.1 - 4e-31 108.4 0.0 3.6e-18 66.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFE43741.1 - 2.9e-14 53.6 0.1 0.00051 19.9 0.0 3.4 2 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFE43741.1 - 1.1e-11 44.6 0.0 3.1e-05 23.5 0.0 3.2 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EFE43741.1 - 0.00046 19.1 1.6 3.1 6.5 0.0 3.8 3 1 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 EFE43741.1 - 0.018 14.8 0.0 0.04 13.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1345 PF07077.11 EFE43741.1 - 0.029 14.1 3.9 0.11 12.2 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) Autophagy_act_C PF03987.15 EFE43741.1 - 0.04 14.5 0.2 0.28 11.8 0.2 2.4 2 0 0 2 2 2 0 Autophagocytosis associated protein, active-site domain T2SSE PF00437.20 EFE43741.1 - 0.063 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF389 PF04087.14 EFE43741.1 - 0.085 12.9 4.5 0.053 13.6 1.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF389) Tannase PF07519.11 EFE43742.1 - 1.6e-66 225.2 0.1 1e-64 219.2 0.0 2.0 1 1 1 2 2 2 2 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EFE43742.1 - 0.022 14.2 0.1 4.2 6.8 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family VWA PF00092.28 EFE43743.1 - 2.6e-08 34.3 0.0 3.8e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFE43743.1 - 0.00025 21.7 0.0 0.0011 19.6 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain ANAPC4 PF12896.7 EFE43746.1 - 2.1e-63 213.5 1.1 3.2e-63 212.9 1.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EFE43746.1 - 2e-30 104.9 0.0 2.1e-29 101.7 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain HEAT PF02985.22 EFE43747.1 - 1.3e-15 56.1 14.8 0.00013 22.0 0.0 9.8 12 0 0 12 12 11 2 HEAT repeat HEAT_EZ PF13513.6 EFE43747.1 - 4.9e-11 42.9 6.1 1.5e-06 28.5 0.0 7.3 7 1 0 7 7 7 1 HEAT-like repeat HEAT_2 PF13646.6 EFE43747.1 - 7.8e-10 39.0 9.8 0.0003 21.1 0.2 7.0 3 2 4 7 7 7 4 HEAT repeats IBN_N PF03810.19 EFE43747.1 - 5.6e-07 29.4 0.8 0.0014 18.5 0.0 4.0 3 0 0 3 3 3 2 Importin-beta N-terminal domain CLASP_N PF12348.8 EFE43747.1 - 1.5e-06 27.9 2.6 0.034 13.7 0.0 4.3 4 1 0 4 4 4 2 CLASP N terminal DUF3385 PF11865.8 EFE43747.1 - 0.00046 20.1 3.1 3.8 7.4 0.5 4.3 4 1 0 5 5 5 2 Domain of unknown function (DUF3385) MMS19_N PF14500.6 EFE43747.1 - 0.0096 15.5 1.6 2.4 7.7 0.8 3.3 2 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II Cse1 PF08506.10 EFE43747.1 - 0.015 14.2 0.0 2.3 7.0 0.0 3.2 3 0 0 3 3 3 0 Cse1 Arm PF00514.23 EFE43747.1 - 0.018 15.1 5.6 27 5.0 0.2 5.6 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Sec7_N PF12783.7 EFE43747.1 - 0.045 13.7 0.5 2.3 8.1 0.3 3.2 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal NUC173 PF08161.12 EFE43747.1 - 0.45 10.2 3.6 71 3.0 0.0 4.1 4 1 0 5 5 5 0 NUC173 domain Uso1_p115_head PF04869.14 EFE43747.1 - 0.52 9.4 5.6 0.98 8.5 0.3 2.8 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, head region Metallophos PF00149.28 EFE43748.1 - 1e-11 45.7 0.0 1.9e-11 44.9 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFE43748.1 - 4.4e-06 27.0 0.0 6.1e-05 23.3 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ribosomal_S8 PF00410.19 EFE43749.1 - 6.7e-17 61.6 0.1 2.2e-16 60.0 0.1 1.8 1 1 0 1 1 1 1 Ribosomal protein S8 Desmo_N PF06771.11 EFE43749.1 - 0.13 12.6 0.0 22 5.5 0.0 2.3 1 1 1 2 2 2 0 Viral Desmoplakin N-terminus PS_Dcarbxylase PF02666.15 EFE43751.1 - 2.7e-75 252.3 0.0 9.8e-75 250.5 0.0 1.8 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Cation_ATPase_N PF00690.26 EFE43752.1 - 1.5e-14 53.4 0.0 1.7e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus E1-E2_ATPase PF00122.20 EFE43753.1 - 8.9e-39 132.9 9.1 7.4e-31 107.1 0.1 3.0 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFE43753.1 - 2.2e-26 92.7 14.1 5.8e-26 91.3 7.4 2.6 3 0 0 3 3 3 2 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFE43753.1 - 7.3e-20 72.1 0.1 1.7e-15 57.9 0.0 3.4 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE43753.1 - 1.5e-15 57.0 0.0 3.2e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFE43753.1 - 2.7e-05 24.0 0.4 0.0024 17.7 0.6 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 EFE43753.1 - 0.004 17.0 0.7 0.0082 16.0 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2463) Wzy_C PF04932.15 EFE43753.1 - 0.35 10.5 0.0 0.35 10.5 0.0 2.5 3 0 0 3 3 3 0 O-Antigen ligase COG4 PF08318.12 EFE43754.1 - 1.7e-84 283.8 0.0 2.2e-84 283.4 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein UPF0184 PF03670.13 EFE43754.1 - 0.14 12.6 0.2 1.8 9.0 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) SIR2 PF02146.17 EFE43755.1 - 1.2e-56 191.4 0.0 1.8e-56 190.9 0.0 1.2 1 0 0 1 1 1 1 Sir2 family Hexokinase_2 PF03727.16 EFE43756.1 - 5.8e-81 271.4 0.0 8.3e-81 270.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EFE43756.1 - 1.2e-72 244.1 0.0 1.5e-72 243.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase ANAPC4_WD40 PF12894.7 EFE43757.1 - 0.00015 22.0 0.1 0.56 10.5 0.1 4.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFE43757.1 - 0.0017 19.1 5.3 1.3 10.1 0.0 5.1 6 0 0 6 6 6 1 WD domain, G-beta repeat SGL PF08450.12 EFE43757.1 - 0.013 15.1 0.1 0.1 12.1 0.0 2.1 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region PikAIV_N PF18605.1 EFE43757.1 - 0.41 10.3 4.4 8.2 6.1 0.3 2.9 3 0 0 3 3 3 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain STIMATE PF12400.8 EFE43758.1 - 2.5e-33 115.3 7.5 8.4e-33 113.6 7.5 1.9 1 1 0 1 1 1 1 STIMATE family Mucin PF01456.17 EFE43758.1 - 6 6.9 23.6 12 5.8 23.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Spore_coat_CotO PF14153.6 EFE43759.1 - 2.8 7.8 14.7 3.1 7.7 14.7 1.0 1 0 0 1 1 1 0 Spore coat protein CotO Sec62 PF03839.16 EFE43759.1 - 8.6 5.8 8.5 8.4 5.8 8.5 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Ammonium_transp PF00909.21 EFE43760.1 - 2.8e-114 381.9 28.8 3.2e-114 381.7 28.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family E1-E2_ATPase PF00122.20 EFE43761.1 - 3.1e-46 157.2 0.2 3.1e-46 157.2 0.2 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFE43761.1 - 1.1e-43 149.0 0.2 1.1e-43 149.0 0.2 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 EFE43761.1 - 3.8e-22 77.7 0.0 8.4e-22 76.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EFE43761.1 - 6.8e-21 75.5 2.1 8.9e-20 71.9 2.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE43761.1 - 6.4e-12 45.4 0.0 1.3e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFE43761.1 - 2e-05 24.5 1.5 0.00038 20.3 0.9 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase CARD_2 PF16739.5 EFE43761.1 - 0.11 12.6 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Caspase recruitment domain Rad21_Rec8_N PF04825.13 EFE43762.1 - 1.3e-37 128.3 0.0 2.3e-37 127.5 0.0 1.3 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EFE43762.1 - 3.3e-07 29.5 0.3 6.9e-07 28.5 0.3 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein Zn_clus PF00172.18 EFE43765.1 - 0.0036 17.4 9.0 0.0036 17.4 9.0 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 EFE43765.1 - 0.039 14.0 0.0 0.083 12.9 0.0 1.5 1 0 0 1 1 1 0 PAS fold Flavokinase PF01687.17 EFE43766.1 - 7.1e-27 93.9 0.0 1.4e-26 93.0 0.0 1.4 1 1 0 1 1 1 1 Riboflavin kinase RSN1_7TM PF02714.15 EFE43767.1 - 1.2e-85 287.2 28.4 1.2e-85 287.2 28.4 1.8 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFE43767.1 - 6.5e-47 159.2 1.0 6.5e-47 159.2 1.0 3.4 3 1 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFE43767.1 - 5.9e-28 98.3 0.7 8e-16 58.8 0.1 2.4 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EFE43767.1 - 8.3e-14 51.5 1.2 1.5e-13 50.7 0.0 2.0 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter SnoaL_2 PF12680.7 EFE43768.1 - 4.4e-07 30.5 0.0 7.9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EFE43768.1 - 0.00012 21.8 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase DLH PF01738.18 EFE43768.1 - 0.03 13.9 0.0 1 8.9 0.0 2.5 1 1 2 3 3 3 0 Dienelactone hydrolase family Indigoidine_A PF04227.12 EFE43769.1 - 6.3e-60 203.0 5.2 7.3e-51 173.2 0.0 2.2 1 1 1 2 2 2 2 Indigoidine synthase A like protein PfkB PF00294.24 EFE43769.1 - 2.2e-13 50.2 0.0 6.8e-08 32.2 0.0 3.1 2 1 0 2 2 2 2 pfkB family carbohydrate kinase Ribophorin_I PF04597.14 EFE43770.1 - 5.5e-141 470.8 0.3 6.2e-141 470.6 0.3 1.0 1 0 0 1 1 1 1 Ribophorin I VTC PF09359.10 EFE43771.1 - 2.8e-99 332.0 0.5 4.2e-99 331.4 0.5 1.3 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 EFE43771.1 - 4.4e-13 49.9 6.4 7.7e-06 26.1 0.0 3.4 2 1 1 3 3 3 3 SPX domain DUF202 PF02656.15 EFE43771.1 - 2.6e-11 43.8 3.6 2.6e-11 43.8 3.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) MCM PF00493.23 EFE43772.1 - 2.5e-102 340.8 0.0 3.6e-102 340.2 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFE43772.1 - 9.5e-37 125.7 0.3 1.9e-36 124.7 0.3 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFE43772.1 - 3e-28 98.1 2.3 3e-28 98.1 2.3 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 EFE43772.1 - 1.2e-18 67.6 0.1 4.7e-18 65.7 0.0 2.1 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFE43772.1 - 7.5e-06 25.5 0.0 0.00025 20.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFE43772.1 - 1.8e-05 24.8 0.1 0.00011 22.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFE43772.1 - 0.0019 18.1 0.0 0.0091 15.9 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_32 PF13654.6 EFE43772.1 - 3.4 6.3 6.8 1.1 8.0 0.7 2.2 2 0 0 2 2 2 0 AAA domain Ank_2 PF12796.7 EFE43773.1 - 0.0019 18.8 0.1 0.33 11.6 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFE43773.1 - 0.01 16.3 0.0 0.036 14.5 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EFE43773.1 - 0.025 15.1 0.0 1.5 9.5 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Methyltransf_2 PF00891.18 EFE43773.1 - 0.093 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain AIF_C PF14721.6 EFE43773.1 - 0.69 10.3 2.5 9.8 6.5 0.1 3.0 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Band_7 PF01145.25 EFE43774.1 - 1.4e-12 48.0 8.8 2.8e-12 47.0 8.8 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family CSTF2_hinge PF14327.6 EFE43775.1 - 2.5e-32 111.1 2.5 2.5e-32 111.1 2.5 2.1 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 EFE43775.1 - 2.3e-17 62.3 8.8 2.3e-17 62.3 8.8 2.6 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.22 EFE43775.1 - 1.2e-15 57.0 0.1 3.2e-15 55.7 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MCCD1 PF15707.5 EFE43775.1 - 0.4 11.2 3.5 0.58 10.6 0.4 2.3 2 0 0 2 2 2 0 Mitochondrial coiled-coil domain protein 1 CCDC53 PF10152.9 EFE43775.1 - 2.2 8.7 4.9 0.81 10.1 1.9 1.7 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex SNF2_N PF00176.23 EFE43776.1 - 7e-23 80.9 0.0 1.8e-12 46.7 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain DNA_methylase PF00145.17 EFE43776.1 - 7.7e-19 68.2 0.0 1.5e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Helicase_C PF00271.31 EFE43776.1 - 0.00011 22.5 0.0 0.001 19.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 EFE43776.1 - 0.28 11.2 27.0 0.075 13.0 10.3 2.8 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFE43776.1 - 0.79 9.8 19.4 0.27 11.3 5.5 3.0 2 0 0 2 2 2 0 RING-type zinc-finger 2Fe-2S_thioredx PF01257.19 EFE43777.1 - 1.3e-58 197.0 0.1 1.7e-58 196.6 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin DUF4139 PF13598.6 EFE43778.1 - 5.9e-30 104.5 0.7 1.3e-29 103.4 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 EFE43778.1 - 2.7e-18 66.2 0.1 2.7e-18 66.2 0.1 3.1 2 1 1 3 3 3 1 N-terminal domain of unknown function (DUF4140) YhzD PF14120.6 EFE43778.1 - 0.077 13.1 5.0 0.56 10.3 5.9 2.0 2 0 0 2 2 2 0 YhzD-like protein RR_TM4-6 PF06459.12 EFE43778.1 - 0.27 11.0 7.5 0.5 10.1 7.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nucleoporin_FG PF13634.6 EFE43778.1 - 0.65 10.9 5.9 1.4 9.8 5.9 1.5 1 0 0 1 1 1 0 Nucleoporin FG repeat region AAA_13 PF13166.6 EFE43778.1 - 1.2 7.7 10.7 1.9 7.1 10.7 1.2 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.19 EFE43778.1 - 1.4 6.7 5.8 2.1 6.2 5.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 EFE43778.1 - 4.4 6.6 6.5 8.1 5.7 6.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 EFE43778.1 - 5.8 7.0 11.5 11 6.1 11.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Sua5_yciO_yrdC PF01300.18 EFE43779.1 - 1.2e-53 181.2 0.0 2e-53 180.6 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EFE43779.1 - 4.7e-32 111.3 0.0 8.3e-32 110.6 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Sec1 PF00995.23 EFE43779.1 - 0.22 10.7 0.0 0.32 10.2 0.0 1.1 1 0 0 1 1 1 0 Sec1 family NFACT-C PF11923.8 EFE43780.1 - 4.5e-37 126.2 0.0 4.5e-37 126.2 0.0 3.6 5 0 0 5 5 5 1 NFACT protein C-terminal domain FbpA PF05833.11 EFE43780.1 - 1.1e-28 100.3 6.9 2.2e-28 99.3 6.9 1.4 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 EFE43780.1 - 9e-28 97.1 0.0 2e-27 96.0 0.0 1.7 1 0 0 1 1 1 1 NFACT protein RNA binding domain DUF1664 PF07889.12 EFE43780.1 - 0.17 11.9 0.8 0.91 9.6 0.8 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Clat_adaptor_s PF01217.20 EFE43781.1 - 9.9e-14 51.5 0.0 2.2e-12 47.1 0.1 2.0 2 0 0 2 2 2 2 Clathrin adaptor complex small chain Tmemb_cc2 PF10267.9 EFE43782.1 - 0.059 12.5 1.5 0.095 11.8 1.5 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein TLE_N PF03920.15 EFE43782.1 - 0.18 11.9 0.3 0.33 11.0 0.3 1.3 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain DUF948 PF06103.11 EFE43783.1 - 0.031 14.5 1.2 0.07 13.4 1.2 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF1515 PF07439.11 EFE43783.1 - 0.13 12.3 10.5 0.034 14.2 4.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) TTKRSYEDQ PF10212.9 EFE43783.1 - 0.64 8.9 10.9 0.083 11.9 5.8 1.9 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Phage_GP20 PF06810.11 EFE43783.1 - 1.1 9.0 19.0 1.1 9.0 13.6 3.2 2 1 1 3 3 3 0 Phage minor structural protein GP20 Bacillus_HBL PF05791.11 EFE43783.1 - 1.4 8.7 7.7 0.61 9.9 3.7 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Laminin_II PF06009.12 EFE43783.1 - 2.1 8.4 10.9 7 6.7 10.9 1.9 1 0 0 1 1 1 0 Laminin Domain II DUF1664 PF07889.12 EFE43783.1 - 2.5 8.2 6.9 1.5 8.9 4.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 EFE43783.1 - 2.6 8.5 11.8 12 6.4 0.3 4.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Pyridoxal_deC PF00282.19 EFE43784.1 - 8.9e-18 64.1 0.0 1.4e-08 33.9 0.0 3.2 3 0 0 3 3 3 3 Pyridoxal-dependent decarboxylase conserved domain DUF3275 PF11679.8 EFE43784.1 - 0.27 11.2 0.1 0.27 11.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) Ribosomal_L16 PF00252.18 EFE43785.1 - 2.3e-36 124.7 0.1 3.7e-36 124.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Importin_rep_4 PF18808.1 EFE43785.1 - 0.15 12.4 0.2 0.37 11.1 0.2 1.6 1 0 0 1 1 1 0 Importin repeat DUF3245 PF11595.8 EFE43785.1 - 0.36 11.3 1.9 0.61 10.5 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) APH PF01636.23 EFE43787.1 - 5.4e-08 33.1 0.0 5.7e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE43787.1 - 0.0036 16.9 0.0 0.0044 16.6 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EFE43787.1 - 0.042 12.7 0.0 0.054 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) FAD_binding_2 PF00890.24 EFE43788.1 - 1.6e-82 277.9 0.1 2e-82 277.5 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EFE43788.1 - 1.1e-09 38.2 2.3 2e-08 34.1 1.4 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 EFE43788.1 - 1.9e-08 34.3 1.0 5.9e-08 32.7 1.0 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFE43788.1 - 4.3e-07 29.5 0.1 0.0027 17.0 0.6 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EFE43788.1 - 2.2e-06 27.1 0.0 5e-05 22.7 0.1 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFE43788.1 - 1e-05 25.7 3.6 2.8e-05 24.2 3.6 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFE43788.1 - 1.1e-05 24.3 1.4 1.9e-05 23.6 0.3 1.8 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EFE43788.1 - 2.4e-05 23.7 0.3 5.1e-05 22.6 0.3 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFE43788.1 - 0.0014 17.9 0.2 0.0026 17.1 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UPF0227 PF05728.12 EFE43788.1 - 0.076 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) GIDA PF01134.22 EFE43788.1 - 0.16 11.0 0.7 0.28 10.2 0.7 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EFE43788.1 - 0.22 10.5 0.5 0.65 9.0 0.2 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein AAA PF00004.29 EFE43789.1 - 1.9e-19 70.4 0.0 6.7e-19 68.6 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFE43789.1 - 9.8e-05 22.8 0.2 0.0013 19.2 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EFE43789.1 - 0.00052 20.0 0.0 0.0013 18.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EFE43789.1 - 0.0037 17.0 0.0 0.0072 16.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EFE43789.1 - 0.0072 16.9 0.1 0.045 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFE43789.1 - 0.0082 16.4 1.5 0.048 13.9 0.0 2.6 2 1 1 3 3 3 1 AAA domain Zot PF05707.12 EFE43789.1 - 0.019 14.6 0.1 0.14 11.8 0.0 2.1 1 1 0 2 2 2 0 Zonular occludens toxin (Zot) Mg_chelatase PF01078.21 EFE43789.1 - 0.041 13.2 0.0 0.095 12.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EFE43789.1 - 0.05 13.7 0.0 0.21 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 EFE43789.1 - 0.08 13.2 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFE43789.1 - 0.088 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 EFE43789.1 - 0.092 12.5 0.0 0.43 10.3 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.13 EFE43789.1 - 0.16 11.3 0.0 0.4 10.0 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 EFE43789.1 - 0.17 12.0 0.0 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain FA_hydroxylase PF04116.13 EFE43790.1 - 1.6e-21 77.0 12.1 1.6e-21 77.0 12.1 1.8 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily OmpA_membrane PF01389.17 EFE43790.1 - 0.093 12.5 0.0 0.29 10.9 0.0 1.7 2 0 0 2 2 2 0 OmpA-like transmembrane domain HA2 PF04408.23 EFE43791.1 - 6.3e-21 74.7 0.0 6.3e-21 74.7 0.0 2.1 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFE43791.1 - 4.5e-12 46.3 0.0 1.1e-11 45.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EFE43791.1 - 4.7e-12 46.1 0.0 1.2e-11 44.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EFE43791.1 - 0.00064 19.5 0.0 0.0019 18.0 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_29 PF13555.6 EFE43791.1 - 0.0053 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFE43791.1 - 0.021 15.1 0.0 0.075 13.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EFE43791.1 - 0.094 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 KaiC Ank_2 PF12796.7 EFE43793.1 - 1.1e-08 35.5 0.0 0.0044 17.6 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFE43793.1 - 1.3e-08 34.9 0.1 0.011 16.1 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFE43793.1 - 5.3e-06 26.9 0.0 0.027 15.0 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE43793.1 - 4.9e-05 23.5 0.1 0.16 12.3 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) SseC PF04888.12 EFE43793.1 - 0.00068 19.3 0.1 0.00095 18.9 0.1 1.2 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family Ank_3 PF13606.6 EFE43793.1 - 0.0024 18.2 0.0 2.9 8.8 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat vWA-TerF-like PF10138.9 EFE43793.1 - 0.0027 17.9 0.0 0.0053 16.9 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF3040 PF11239.8 EFE43793.1 - 0.034 14.4 0.9 0.084 13.1 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) LMF1 PF06762.14 EFE43794.1 - 0.2 10.7 5.3 0.26 10.4 5.3 1.1 1 0 0 1 1 1 0 Lipase maturation factor Trypsin_2 PF13365.6 EFE43795.1 - 1.7e-07 32.2 0.0 4.5e-07 30.9 0.0 1.7 2 0 0 2 2 2 1 Trypsin-like peptidase domain Kelch_6 PF13964.6 EFE43796.1 - 0.027 14.8 0.1 10 6.6 0.1 3.0 3 0 0 3 3 3 0 Kelch motif RTA1 PF04479.13 EFE43797.1 - 1.3e-38 132.7 3.1 1.5e-38 132.5 3.1 1.0 1 0 0 1 1 1 1 RTA1 like protein SNF2_N PF00176.23 EFE43798.1 - 2.2e-52 177.9 0.1 5.3e-51 173.4 0.1 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE43798.1 - 4.8e-16 59.1 0.1 3.2e-15 56.4 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE43798.1 - 1.3e-05 25.3 0.0 5e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 EFE43798.1 - 3.2e-05 23.7 11.9 3.2e-05 23.7 11.9 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) AAA_34 PF13872.6 EFE43798.1 - 0.00036 19.5 0.0 0.00087 18.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 zf-C3HC4_3 PF13920.6 EFE43798.1 - 0.0026 17.6 10.7 0.0026 17.6 10.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFE43798.1 - 0.009 16.3 11.9 0.009 16.3 11.9 2.6 2 0 0 2 2 2 1 Ring finger domain C2 PF00168.30 EFE43799.1 - 2.4e-10 40.6 0.0 4.3e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain MMR1 PF08505.10 EFE43799.1 - 0.0017 18.7 1.3 0.0017 18.7 1.3 1.6 2 0 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein Pex2_Pex12 PF04757.14 EFE43800.1 - 3.3e-42 144.6 3.1 4.2e-42 144.2 3.1 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 EFE43800.1 - 2.6e-11 43.2 10.0 4.2e-11 42.5 10.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFE43800.1 - 6.7e-11 42.4 10.4 1e-10 41.8 10.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFE43800.1 - 1.4e-10 40.9 7.6 2.2e-10 40.3 7.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE43800.1 - 2.4e-10 40.1 5.8 3.5e-10 39.6 5.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE43800.1 - 4.8e-08 32.9 9.3 9.7e-08 31.9 9.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFE43800.1 - 4.7e-07 29.6 7.2 7.6e-07 28.9 7.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFE43800.1 - 5.5e-07 29.4 6.6 8.8e-07 28.8 6.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EFE43800.1 - 6.1e-07 29.6 7.2 1.2e-06 28.7 7.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EFE43800.1 - 4.7e-06 26.7 9.4 7.9e-06 25.9 9.4 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EFE43800.1 - 0.0016 18.5 5.4 0.0029 17.7 5.4 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EFE43800.1 - 0.0076 16.3 3.0 0.013 15.5 3.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EFE43800.1 - 0.01 15.7 3.5 0.019 14.8 3.5 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 EFE43800.1 - 0.023 14.5 4.9 0.042 13.7 4.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 EFE43800.1 - 0.16 11.8 7.6 0.32 10.8 7.6 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Rtf2 PF04641.12 EFE43800.1 - 0.25 10.7 0.9 0.47 9.8 0.9 1.5 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_11 PF17123.5 EFE43800.1 - 0.34 10.7 4.1 0.9 9.3 4.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EFE43800.1 - 0.47 10.1 4.7 0.84 9.3 4.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type IBR PF01485.21 EFE43800.1 - 0.52 10.6 4.4 1.2 9.4 4.4 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain EXS PF03124.14 EFE43801.1 - 1.2e-97 327.2 11.9 3.4e-97 325.7 11.9 1.6 1 1 0 1 1 1 1 EXS family DUF3431 PF11913.8 EFE43802.1 - 1.5e-73 247.1 3.8 1.2e-57 195.2 0.5 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3431) NIR_SIR PF01077.22 EFE43803.1 - 1.3e-53 180.8 0.0 2.9e-46 156.9 0.0 2.7 3 0 0 3 3 3 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 EFE43803.1 - 9.8e-29 99.0 0.0 9.6e-14 51.0 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 EFE43803.1 - 9.1e-28 97.3 0.0 1.8e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 EFE43803.1 - 3.7e-05 23.6 0.8 0.00011 22.1 0.1 1.9 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Kei1 PF08552.11 EFE43804.1 - 2.5e-51 174.3 0.3 3.5e-51 173.8 0.0 1.4 2 0 0 2 2 2 1 Inositolphosphorylceramide synthase subunit Kei1 Ras PF00071.22 EFE43805.1 - 2.2e-47 160.7 1.8 4.7e-46 156.3 1.8 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFE43805.1 - 3.8e-27 94.9 0.7 1.7e-25 89.6 0.7 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE43805.1 - 9.9e-11 41.4 0.6 2e-10 40.4 0.6 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFE43805.1 - 0.00029 20.4 0.1 0.00092 18.8 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFE43805.1 - 0.0037 17.2 0.3 0.018 15.0 0.2 1.9 1 1 0 2 2 2 1 RsgA GTPase TetR_C_16 PF17920.1 EFE43805.1 - 0.15 12.3 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Radial_spoke PF04712.12 EFE43806.1 - 4.4 6.1 7.9 4.3 6.2 7.9 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein Myc_N PF01056.18 EFE43806.1 - 6.1 6.6 7.6 6.1 6.6 7.6 1.0 1 0 0 1 1 1 0 Myc amino-terminal region ATP-synt_C PF00137.21 EFE43807.1 - 6.3e-21 74.5 24.2 7.8e-12 45.4 6.4 2.2 2 0 0 2 2 2 2 ATP synthase subunit C SLATT_5 PF18160.1 EFE43807.1 - 0.36 10.1 5.1 0.082 12.2 0.7 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 MoCF_biosynth PF00994.24 EFE43808.1 - 2.4e-11 43.5 0.0 2.9e-11 43.2 0.0 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_N PF03453.17 EFE43809.1 - 2.7e-37 128.0 2.5 4.4e-37 127.3 2.5 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 EFE43809.1 - 9.1e-28 96.7 0.0 4.8e-23 81.4 0.0 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_C PF03454.15 EFE43809.1 - 2.6e-18 66.0 0.1 5.7e-18 64.9 0.1 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) DDHD PF02862.17 EFE43810.1 - 9e-27 94.7 0.0 9.7e-25 88.0 0.0 2.5 1 1 0 1 1 1 1 DDHD domain CENP-U PF13097.6 EFE43810.1 - 0.16 11.9 0.1 0.35 10.8 0.1 1.4 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit FAD_binding_3 PF01494.19 EFE43812.1 - 2.2e-54 185.0 0.0 3.9e-38 131.6 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Phe_hydrox_dim PF07976.12 EFE43812.1 - 7.4e-35 120.4 0.0 1.2e-34 119.7 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain DAO PF01266.24 EFE43812.1 - 0.00011 21.9 0.1 0.019 14.5 0.0 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE43812.1 - 0.043 14.1 0.0 0.093 13.0 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE43812.1 - 0.059 12.6 0.0 0.24 10.6 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EFE43812.1 - 0.062 13.0 0.0 0.62 9.7 0.0 2.2 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DUF866 PF05907.13 EFE43813.1 - 3.7e-24 85.4 0.4 3.7e-24 85.4 0.4 1.5 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) YL1 PF05764.13 EFE43813.1 - 0.00035 20.8 2.5 0.0004 20.6 2.5 1.1 1 0 0 1 1 1 1 YL1 nuclear protein DUF755 PF05501.11 EFE43813.1 - 0.033 14.4 10.1 0.045 14.0 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) IFP_35_N PF07334.13 EFE43813.1 - 0.16 12.1 1.9 0.28 11.3 1.9 1.4 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus RBP_receptor PF14752.6 EFE43813.1 - 0.35 9.4 0.9 0.45 9.0 0.9 1.0 1 0 0 1 1 1 0 Retinol binding protein receptor SR-25 PF10500.9 EFE43814.1 - 0.15 11.6 5.0 0.17 11.4 5.0 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PI3K_1B_p101 PF10486.9 EFE43814.1 - 0.41 8.4 3.9 0.46 8.2 3.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PAC1 PF16094.5 EFE43814.1 - 0.42 9.7 1.5 0.43 9.7 1.5 1.0 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Ras PF00071.22 EFE43816.1 - 2e-47 160.8 0.0 2.5e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE43816.1 - 5.6e-20 71.7 0.0 1e-19 70.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE43816.1 - 0.00016 21.1 0.0 0.00026 20.5 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFE43816.1 - 0.022 14.2 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EFE43816.1 - 0.081 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PAP2 PF01569.21 EFE43818.1 - 6.7e-18 64.8 2.2 2e-17 63.2 2.2 1.7 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EFE43818.1 - 0.23 11.1 10.6 1.3 8.7 10.6 2.3 1 1 0 1 1 1 0 PAP2 superfamily Peptidase_C48 PF02902.19 EFE43820.1 - 7e-27 94.7 0.0 1.1e-26 94.0 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain MSA_2 PF00985.17 EFE43821.1 - 0.76 10.1 7.2 1.6 9.1 7.2 1.4 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family DUF1664 PF07889.12 EFE43822.1 - 0.0084 16.1 4.5 0.54 10.3 1.2 3.1 2 1 1 3 3 3 2 Protein of unknown function (DUF1664) Spc7 PF08317.11 EFE43822.1 - 0.0095 14.9 1.1 0.015 14.2 1.1 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein CCDC144C PF14915.6 EFE43822.1 - 0.01 15.0 0.2 0.022 13.9 0.1 1.4 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region ADIP PF11559.8 EFE43822.1 - 0.01 15.9 2.4 0.13 12.4 2.1 2.2 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding WEMBL PF05701.11 EFE43822.1 - 0.018 13.8 0.3 0.026 13.2 0.3 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Fez1 PF06818.15 EFE43822.1 - 0.037 14.5 1.7 0.17 12.4 0.1 2.2 1 1 0 1 1 1 0 Fez1 TPR_MLP1_2 PF07926.12 EFE43822.1 - 0.046 13.8 0.1 5.8 7.0 0.1 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein COG5 PF10392.9 EFE43822.1 - 0.067 13.4 1.2 0.4 10.8 1.2 2.3 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Baculo_PEP_C PF04513.12 EFE43822.1 - 0.067 13.2 0.2 0.15 12.1 0.1 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus YlqD PF11068.8 EFE43822.1 - 0.068 13.5 1.0 0.13 12.7 0.2 1.8 2 0 0 2 2 2 0 YlqD protein LPP PF04728.13 EFE43822.1 - 0.069 13.6 6.1 1.6 9.2 0.2 3.9 3 1 1 4 4 3 0 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 EFE43822.1 - 0.096 12.7 0.8 0.63 10.1 0.8 2.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF641 PF04859.12 EFE43822.1 - 0.11 12.8 0.9 1.7 9.0 0.2 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) NPV_P10 PF05531.12 EFE43822.1 - 0.2 12.1 2.1 46 4.6 0.0 3.4 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Syntaxin_2 PF14523.6 EFE43822.1 - 1.2 9.5 4.0 1.3 9.4 1.8 2.2 1 1 1 2 2 2 0 Syntaxin-like protein TolA_bind_tri PF16331.5 EFE43822.1 - 5.8 7.1 6.1 16 5.7 0.3 3.0 2 1 1 3 3 3 0 TolA binding protein trimerisation Sulfotransfer_3 PF13469.6 EFE43823.1 - 0.0039 17.6 0.0 0.64 10.4 0.0 2.3 2 0 0 2 2 2 2 Sulfotransferase family adh_short_C2 PF13561.6 EFE43825.1 - 4.2e-54 183.6 0.4 5e-54 183.3 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE43825.1 - 7.7e-47 159.3 0.4 9.7e-47 159.0 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE43825.1 - 3.1e-10 40.2 0.3 7.9e-10 38.9 0.3 1.6 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EFE43825.1 - 0.0035 17.6 0.0 0.0067 16.7 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DENN PF02141.21 EFE43827.1 - 1.1e-37 129.8 0.0 1.9e-37 129.0 0.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EFE43827.1 - 2.6e-06 28.1 0.1 1.2e-05 26.0 0.0 2.2 2 0 0 2 2 2 1 uDENN domain Elongin_A PF06881.11 EFE43827.1 - 0.058 13.9 7.8 0.038 14.5 5.0 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Cnn_1N PF07989.11 EFE43827.1 - 1.3 9.3 12.7 0.12 12.5 2.9 2.7 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 TMF_TATA_bd PF12325.8 EFE43827.1 - 1.9 8.7 16.8 0.52 10.5 3.4 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Git3 PF11710.8 EFE43828.1 - 1.8e-23 83.4 18.8 4.8e-23 82.0 18.8 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EFE43828.1 - 2.6e-10 40.2 0.7 2.6e-10 40.2 0.7 2.4 3 0 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 EFE43828.1 - 0.13 11.4 16.7 0.25 10.4 16.7 1.6 1 1 0 1 1 1 0 Slime mold cyclic AMP receptor MOR2-PAG1_N PF14222.6 EFE43829.1 - 1.1e-208 694.7 0.0 1.7e-208 694.1 0.0 1.3 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EFE43829.1 - 3.6e-86 289.1 1.0 7.7e-86 288.1 0.1 2.1 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EFE43829.1 - 4.2e-40 137.3 12.6 5.6e-18 64.1 0.1 4.1 2 1 1 3 3 3 3 Cell morphogenesis central region HEAT_EZ PF13513.6 EFE43829.1 - 0.025 15.1 2.5 38 4.9 0.0 5.2 5 0 0 5 5 5 0 HEAT-like repeat FAD_binding_1 PF00667.20 EFE43830.1 - 3.1e-67 226.4 0.0 4.5e-67 225.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFE43830.1 - 1e-33 116.5 0.7 2e-33 115.6 0.7 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFE43830.1 - 1.5e-21 77.1 0.0 1.4e-20 73.9 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EFE43830.1 - 0.11 12.7 0.1 1.7 8.9 0.0 2.3 2 0 0 2 2 2 0 Flavodoxin domain RRM_1 PF00076.22 EFE43831.1 - 8.6e-05 22.3 0.0 0.00017 21.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAPS_reduct PF01507.19 EFE43833.1 - 4.8e-29 101.6 0.0 3.5e-27 95.5 0.0 2.2 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family RPA_C PF08784.11 EFE43834.1 - 2.7e-14 53.7 0.1 6.2e-14 52.5 0.0 1.7 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EFE43834.1 - 0.0004 20.3 0.0 0.0024 17.8 0.0 2.1 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain DEAD PF00270.29 EFE43835.1 - 2.3e-47 161.0 0.0 9.1e-47 159.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE43835.1 - 9.1e-24 83.9 0.1 3.8e-23 82.0 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EFE43835.1 - 1e-19 70.5 1.7 4e-19 68.6 1.7 2.1 1 0 0 1 1 1 1 DBP10CT (NUC160) domain AA_permease PF00324.21 EFE43837.1 - 1.8e-117 392.9 40.5 7.4e-74 249.1 12.7 2.0 2 0 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EFE43837.1 - 3.9e-32 111.6 43.7 1.6e-31 109.6 43.7 1.8 1 1 0 1 1 1 1 Amino acid permease PrgI PF12666.7 EFE43837.1 - 0.032 14.9 1.0 0.032 14.9 1.0 3.6 4 1 1 5 5 5 0 PrgI family protein DEAD PF00270.29 EFE43838.1 - 7.9e-48 162.5 0.0 1.6e-47 161.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE43838.1 - 3.4e-24 85.3 0.0 2.6e-23 82.5 0.0 2.6 2 1 1 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFE43838.1 - 3.9e-21 75.0 0.0 1e-20 73.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFE43838.1 - 8.5e-08 32.4 0.0 3.2e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 EFE43838.1 - 0.024 14.8 0.0 0.082 13.1 0.0 1.9 1 0 0 1 1 1 0 Helicase C-terminal domain DUF4407 PF14362.6 EFE43838.1 - 3.4 6.9 5.7 9.9 5.4 5.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DnaJ PF00226.31 EFE43839.1 - 1.7e-14 53.7 1.3 5.8e-14 52.0 0.4 2.3 2 0 0 2 2 2 1 DnaJ domain Afi1 PF07792.12 EFE43839.1 - 10 6.6 6.5 1.8 9.1 2.8 1.7 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MatE PF01554.18 EFE43840.1 - 5.3e-57 192.0 32.9 9.1e-35 119.7 11.9 2.4 2 0 0 2 2 2 2 MatE FAM27 PF15832.5 EFE43840.1 - 0.18 12.3 0.4 0.31 11.6 0.4 1.3 1 0 0 1 1 1 0 FAM27 D and E protein family DUF202 PF02656.15 EFE43841.1 - 1.1e-15 57.8 5.4 2.4e-15 56.7 1.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF202) NUDIX PF00293.28 EFE43842.1 - 7.8e-27 93.9 0.0 1e-26 93.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF3927 PF13064.6 EFE43843.1 - 1.1 9.3 5.7 0.44 10.6 2.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3927) zf-C2H2 PF00096.26 EFE43844.1 - 1e-06 28.9 12.9 0.00053 20.3 3.4 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE43844.1 - 1.8e-06 28.3 7.0 0.0024 18.6 1.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFE43844.1 - 0.053 14.0 8.9 3.8 8.1 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger double domain Pkinase PF00069.25 EFE43845.1 - 7e-18 64.9 0.0 1.2e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EFE43845.1 - 9.2e-09 34.8 6.9 0.47 10.8 0.1 6.4 6 0 0 6 6 6 3 HEAT repeat WD40 PF00400.32 EFE43845.1 - 5.3e-07 30.2 13.1 3.3e-05 24.6 0.0 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 EFE43845.1 - 6e-05 22.5 0.0 0.0001 21.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ge1_WD40 PF16529.5 EFE43845.1 - 0.014 14.3 0.0 0.18 10.8 0.0 2.6 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HEAT_EZ PF13513.6 EFE43845.1 - 0.029 14.9 0.3 0.26 11.8 0.1 2.8 3 0 0 3 3 3 0 HEAT-like repeat Tti2 PF10521.9 EFE43845.1 - 0.054 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Tti2 family RabGAP-TBC PF00566.18 EFE43846.1 - 8.6e-42 143.2 0.0 5.5e-40 137.3 0.0 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DUF3322 PF11795.8 EFE43846.1 - 0.24 11.4 2.3 0.24 11.4 0.3 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Peptidase_M6 PF05547.11 EFE43847.1 - 2.7e-06 26.0 0.6 0.00028 19.4 0.5 2.2 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 THF_DHG_CYH PF00763.23 EFE43848.1 - 0.01 16.1 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Abhydrolase_4 PF08386.10 EFE43848.1 - 0.013 15.6 0.0 0.02 15.0 0.0 1.2 1 0 0 1 1 1 0 TAP-like protein DUF5642 PF18702.1 EFE43848.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5642) COesterase PF00135.28 EFE43849.1 - 3.2e-88 296.8 0.0 3.9e-88 296.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE43849.1 - 2.2e-06 27.7 0.0 6e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE43849.1 - 0.00048 20.8 0.0 0.0014 19.3 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFE43849.1 - 0.00054 19.5 0.0 0.001 18.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family SmpA_OmlA PF04355.13 EFE43849.1 - 0.046 13.5 0.3 9.1 6.2 0.0 2.6 2 0 0 2 2 2 0 SmpA / OmlA family DUF1749 PF08538.10 EFE43849.1 - 0.05 12.7 0.0 0.072 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Nop14 PF04147.12 EFE43850.1 - 5.7e-278 924.8 28.5 1.1e-277 923.8 28.5 1.5 1 1 0 1 1 1 1 Nop14-like family FNIP_C PF14638.6 EFE43850.1 - 0.14 11.8 0.0 0.5 10.0 0.0 1.8 2 0 0 2 2 2 0 Folliculin-interacting protein C-terminus Phage-MuB_C PF09077.11 EFE43851.1 - 0.21 11.5 0.0 0.38 10.7 0.0 1.3 1 0 0 1 1 1 0 Mu B transposition protein, C terminal PPR_2 PF13041.6 EFE43852.1 - 7.5e-08 32.4 0.2 1.8 8.8 0.0 5.6 6 0 0 6 6 6 3 PPR repeat family PPR_3 PF13812.6 EFE43852.1 - 0.028 14.5 0.1 4.4 7.5 0.0 3.3 3 0 0 3 3 3 0 Pentatricopeptide repeat domain PPR PF01535.20 EFE43852.1 - 0.24 11.7 1.2 6.5 7.2 0.0 3.9 5 0 0 5 5 5 0 PPR repeat ORC3_N PF07034.11 EFE43853.1 - 4.3e-18 65.5 0.1 1.1e-12 47.7 0.0 2.1 1 1 0 2 2 2 2 Origin recognition complex (ORC) subunit 3 N-terminus UPF0014 PF03649.13 EFE43853.1 - 0.057 12.8 0.1 0.082 12.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0014) FliG_C PF01706.16 EFE43853.1 - 0.059 13.6 0.1 0.12 12.6 0.1 1.7 1 1 0 1 1 1 0 FliG C-terminal domain ORC_WH_C PF18137.1 EFE43854.1 - 1.6e-25 89.8 0.2 1.3e-15 57.7 0.0 3.3 2 1 1 3 3 3 2 Origin recognition complex winged helix C-terminal Sec66 PF09802.9 EFE43855.1 - 2.5e-78 261.8 0.6 3e-78 261.5 0.6 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF3848 PF12959.7 EFE43855.1 - 0.00019 21.4 0.1 0.00035 20.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3848) DUF2465 PF10239.9 EFE43855.1 - 0.023 13.9 0.1 0.032 13.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) DUF1539 PF07560.11 EFE43855.1 - 0.066 13.3 0.0 0.12 12.5 0.0 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) AAA PF00004.29 EFE43856.1 - 2.8e-46 157.2 0.0 8.5e-42 142.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE43856.1 - 6.7e-10 38.6 0.0 2.9e-09 36.6 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EFE43856.1 - 3.7e-06 27.4 0.1 5.3e-05 23.7 0.2 2.8 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EFE43856.1 - 3.7e-06 26.8 0.0 9.2e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 EFE43856.1 - 1.3e-05 25.4 0.0 2.9e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Bromodomain PF00439.25 EFE43856.1 - 0.00019 21.4 0.0 0.0005 20.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain AAA_5 PF07728.14 EFE43856.1 - 0.00041 20.4 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFE43856.1 - 0.0017 18.7 0.4 0.07 13.4 0.3 3.2 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFE43856.1 - 0.0051 17.2 0.0 0.014 15.8 0.0 1.8 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 EFE43856.1 - 0.007 15.6 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EFE43856.1 - 0.0076 16.4 0.0 0.026 14.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFE43856.1 - 0.013 15.1 0.0 0.039 13.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.6 EFE43856.1 - 0.019 15.0 0.0 0.048 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFE43856.1 - 0.027 15.0 0.0 0.093 13.2 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 EFE43856.1 - 0.042 13.6 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFE43856.1 - 0.042 13.2 0.0 0.096 12.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFE43856.1 - 0.063 13.8 0.0 0.22 12.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EFE43856.1 - 0.073 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EFE43856.1 - 0.074 12.7 0.0 3.3 7.4 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EFE43856.1 - 0.1 12.7 0.0 3.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 EFE43856.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_3 PF07726.11 EFE43856.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EFE43856.1 - 0.17 11.3 0.0 0.32 10.4 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 EFE43856.1 - 0.2 10.7 0.0 0.35 9.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PIF1 PF05970.14 EFE43857.1 - 4.7e-99 332.0 0.0 7.4e-99 331.3 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 EFE43857.1 - 3.2e-51 174.3 0.9 6.5e-51 173.3 0.7 1.7 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 EFE43857.1 - 9e-09 35.3 0.0 1.6e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFE43857.1 - 0.015 15.3 0.2 0.084 12.9 0.1 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFE43857.1 - 0.015 15.7 0.0 0.044 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 EFE43857.1 - 0.028 14.7 0.2 0.11 12.8 0.1 2.1 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 EFE43857.1 - 0.059 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.15 EFE43857.1 - 0.085 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TsaE PF02367.17 EFE43857.1 - 0.085 12.9 0.0 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2791 PF10923.8 EFE43857.1 - 0.11 11.4 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) AAA_25 PF13481.6 EFE43857.1 - 0.19 11.3 0.0 0.51 9.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain Dimer_Tnp_hAT PF05699.14 EFE43858.1 - 1.5e-14 53.5 0.0 3.7e-14 52.3 0.0 1.7 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF4413 PF14372.6 EFE43858.1 - 0.022 15.1 0.1 0.06 13.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) BUD22 PF09073.10 EFE43859.1 - 0.68 9.2 34.3 0.71 9.1 34.3 1.1 1 0 0 1 1 1 0 BUD22 LAP1C PF05609.12 EFE43859.1 - 0.94 8.5 25.4 1 8.4 25.4 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SDA1 PF05285.12 EFE43859.1 - 1.1 8.7 40.0 1.3 8.3 40.0 1.1 1 0 0 1 1 1 0 SDA1 SOBP PF15279.6 EFE43859.1 - 1.7 9.2 12.4 1.9 9.0 12.4 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein SWIRM-assoc_2 PF16496.5 EFE43859.1 - 2.8 6.7 25.5 3.3 6.5 25.5 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Presenilin PF01080.17 EFE43859.1 - 3.8 6.2 22.6 5.1 5.8 22.6 1.3 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 EFE43859.1 - 4.6 5.9 23.4 6.3 5.5 23.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF966 PF06136.13 EFE43859.1 - 7.2 6.2 23.9 8.7 6.0 23.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF1308 PF07000.11 EFE43860.1 - 1.5e-13 51.0 0.0 7.8e-13 48.7 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1308) DUF2408 PF10303.9 EFE43860.1 - 0.088 13.4 0.3 0.44 11.1 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) WD40 PF00400.32 EFE43861.1 - 9e-13 48.5 1.1 0.0002 22.1 0.1 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE43861.1 - 7.8e-06 26.1 0.0 0.0031 17.8 0.0 3.7 1 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain TruB_C PF09142.11 EFE43861.1 - 0.16 11.7 0.0 0.45 10.3 0.0 1.7 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal Frtz PF11768.8 EFE43861.1 - 0.25 9.6 0.0 0.45 8.8 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Mito_carr PF00153.27 EFE43862.1 - 2.9e-34 116.8 1.4 5.6e-17 61.4 0.2 2.4 3 0 0 3 3 3 2 Mitochondrial carrier protein Ribonuc_red_sm PF00268.21 EFE43863.1 - 1.6e-121 405.1 1.7 2e-121 404.7 1.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain G6PD_C PF02781.16 EFE43865.1 - 1.6e-114 382.0 0.0 2.4e-114 381.4 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EFE43865.1 - 1.7e-52 178.6 0.0 4.1e-52 177.4 0.0 1.7 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Abhydrolase_3 PF07859.13 EFE43866.1 - 5.6e-32 111.3 0.0 8.1e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EFE43866.1 - 0.016 15.3 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Methyltr_RsmB-F PF01189.17 EFE43867.1 - 4.8e-31 108.0 0.0 3.3e-23 82.4 0.0 3.3 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F ECF_trnsprt PF12822.7 EFE43868.1 - 0.026 14.7 0.0 0.031 14.4 0.0 1.1 1 0 0 1 1 1 0 ECF transporter, substrate-specific component API5 PF05918.11 EFE43868.1 - 0.22 10.3 0.5 0.25 10.1 0.5 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) CYSTM PF12734.7 EFE43869.1 - 3.5e-14 52.8 12.9 3.5e-14 52.8 12.9 4.0 2 1 0 2 2 2 1 Cysteine-rich TM module stress tolerance Pex14_N PF04695.13 EFE43869.1 - 0.37 11.4 8.8 0.48 11.1 8.8 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2076 PF09849.9 EFE43869.1 - 0.73 9.8 16.6 1.2 9.2 16.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF2968 PF11180.8 EFE43870.1 - 0.00037 20.2 9.4 0.00037 20.2 9.4 4.2 3 1 1 4 4 4 2 Protein of unknown function (DUF2968) DUF4363 PF14276.6 EFE43870.1 - 0.0079 16.3 4.1 0.0079 16.3 4.1 4.2 3 1 0 4 4 4 1 Domain of unknown function (DUF4363) Spectrin PF00435.21 EFE43870.1 - 0.017 15.6 9.1 0.017 15.6 9.1 3.6 3 1 0 3 3 3 0 Spectrin repeat Fib_alpha PF08702.10 EFE43870.1 - 0.019 15.1 4.0 0.019 15.1 4.0 4.6 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Helicase_IV_N PF12462.8 EFE43870.1 - 0.045 13.7 0.3 0.045 13.7 0.3 3.2 3 1 0 3 3 3 0 DNA helicase IV / RNA helicase N terminal APG6_N PF17675.1 EFE43870.1 - 0.1 13.1 52.1 0.027 15.0 18.4 4.5 2 1 1 4 4 4 0 Apg6 coiled-coil region DUF1664 PF07889.12 EFE43870.1 - 2.9 7.9 21.6 0.9 9.6 2.9 4.0 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 EFE43870.1 - 3.9 7.5 39.9 0.92 9.5 17.4 4.1 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 EFE43870.1 - 8.9 6.3 17.0 1.7 8.7 3.4 3.5 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus RNA_pol_Rpb5_C PF01191.19 EFE43871.1 - 9.8e-34 115.1 0.1 1.7e-33 114.3 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EFE43871.1 - 3.8e-26 91.5 0.0 6e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EFE43871.1 - 0.00035 20.6 0.0 0.00091 19.2 0.0 1.6 2 0 0 2 2 2 1 Restriction endonuclease DLH PF01738.18 EFE43872.1 - 1.9e-11 43.9 0.0 2.5e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EFE43872.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold ETRAMP PF09716.10 EFE43874.1 - 0.071 13.2 0.8 0.098 12.7 0.8 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF1754 PF08555.10 EFE43875.1 - 9.9e-15 55.1 19.8 1.7e-14 54.4 19.8 1.4 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) HSP70 PF00012.20 EFE43875.1 - 0.75 7.9 11.1 0.91 7.6 11.1 1.0 1 0 0 1 1 1 0 Hsp70 protein PTPA PF03095.15 EFE43876.1 - 1.9e-106 355.9 0.0 2.2e-106 355.7 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF202 PF02656.15 EFE43877.1 - 6.9e-22 77.7 0.3 6.9e-22 77.7 0.3 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF202) ETRAMP PF09716.10 EFE43878.1 - 3.1 7.9 0.0 3.1 7.9 0.0 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Rrn6 PF10214.9 EFE43878.1 - 3.5 6.0 20.7 0.57 8.6 0.2 2.2 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Atg14 PF10186.9 EFE43878.1 - 9.5 5.2 20.0 14 4.6 20.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nop14 PF04147.12 EFE43879.1 - 0.15 10.2 15.6 0.041 12.1 7.3 2.3 2 0 0 2 2 2 0 Nop14-like family PAF-AH_p_II PF03403.13 EFE43880.1 - 5.4e-15 54.8 0.0 1.5e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Hydrolase_4 PF12146.8 EFE43880.1 - 0.00018 20.9 0.0 0.17 11.1 0.0 2.6 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EFE43880.1 - 0.0013 17.7 0.1 0.0043 16.0 0.1 1.7 1 1 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_5 PF12695.7 EFE43880.1 - 0.045 13.5 0.0 0.47 10.2 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFE43880.1 - 0.077 12.6 0.0 0.63 9.6 0.0 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.11 EFE43880.1 - 0.12 12.2 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Methyltransf_34 PF11312.8 EFE43881.1 - 1.9e-100 336.0 0.0 4.2e-100 334.9 0.0 1.5 1 1 1 2 2 2 1 Putative SAM-dependent methyltransferase Band_7 PF01145.25 EFE43883.1 - 1.4e-24 87.1 8.0 3.3e-24 85.9 8.0 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EFE43883.1 - 0.0009 18.4 4.3 0.0013 17.9 4.3 1.3 1 0 0 1 1 1 1 SigmaW regulon antibacterial GatB_Yqey PF02637.18 EFE43883.1 - 0.023 14.6 0.6 0.04 13.8 0.6 1.4 1 0 0 1 1 1 0 GatB domain UcrQ PF02939.16 EFE43884.1 - 1.2e-25 89.2 1.4 3.8e-24 84.4 0.7 2.0 1 1 1 2 2 2 2 UcrQ family F-box-like_2 PF13013.6 EFE43884.1 - 0.0065 16.4 0.1 0.0084 16.1 0.1 1.2 1 0 0 1 1 1 1 F-box-like domain Ribosomal_L7Ae PF01248.26 EFE43885.1 - 3.5e-18 65.1 1.4 3.5e-18 65.1 1.4 2.5 2 1 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Rib_recp_KP_reg PF05104.12 EFE43885.1 - 0.016 16.2 15.3 0.016 16.2 15.3 2.2 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region FSIP1 PF15554.6 EFE43887.1 - 0.1 11.7 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 FSIP1 family SET PF00856.28 EFE43888.1 - 0.0018 18.7 0.0 0.0038 17.6 0.0 1.7 1 1 0 1 1 1 1 SET domain Fungal_trans PF04082.18 EFE43889.1 - 8.7e-31 106.9 0.5 1.6e-30 106.0 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE43889.1 - 1.4e-09 37.9 11.7 2.1e-09 37.3 11.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Trimer_CC PF08954.11 EFE43889.1 - 0.022 14.3 1.5 0.063 12.9 1.5 1.8 1 0 0 1 1 1 0 Trimerisation motif bZIP_1 PF00170.21 EFE43889.1 - 0.21 11.7 0.6 0.56 10.3 0.1 1.9 2 0 0 2 2 2 0 bZIP transcription factor PKcGMP_CC PF16808.5 EFE43889.1 - 1.6 8.6 4.1 1 9.3 1.3 2.0 1 1 1 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Transketolase_N PF00456.21 EFE43890.1 - 8.4e-147 488.5 0.0 1.6e-146 487.6 0.0 1.5 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EFE43890.1 - 6.3e-46 156.3 0.0 1e-45 155.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFE43890.1 - 2.3e-12 46.9 0.0 5e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EFE43890.1 - 2.4e-05 23.7 0.0 0.0001 21.6 0.0 1.7 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Mur_ligase_C PF02875.21 EFE43890.1 - 0.066 13.5 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain TPP_enzyme_C PF02775.21 EFE43890.1 - 0.55 10.0 7.8 0.1 12.3 1.3 2.6 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Spermine_synth PF01564.17 EFE43891.1 - 1.1e-05 24.9 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synth PF01564.17 EFE43892.1 - 6.2e-56 188.8 0.0 8.4e-56 188.4 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EFE43892.1 - 1.8e-23 82.1 0.1 3.2e-23 81.4 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EFE43892.1 - 1.5e-05 25.6 0.0 2.6e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE43892.1 - 7.2e-05 22.6 0.0 0.00012 21.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE43892.1 - 0.00052 20.7 0.3 0.0031 18.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.16 EFE43892.1 - 0.0043 16.3 0.0 0.0059 15.9 0.0 1.1 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain Methyltransf_30 PF05430.11 EFE43892.1 - 0.019 14.8 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 EFE43892.1 - 0.023 14.2 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.7 EFE43892.1 - 0.026 14.5 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EFE43892.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain bZIP_1 PF00170.21 EFE43893.1 - 9.8e-09 35.2 9.7 1.7e-08 34.5 9.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor TMF_TATA_bd PF12325.8 EFE43893.1 - 0.00012 22.3 1.6 0.00016 21.8 1.6 1.2 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding bZIP_2 PF07716.15 EFE43893.1 - 0.0018 18.3 7.1 0.0018 18.3 7.1 2.1 1 1 1 2 2 2 1 Basic region leucine zipper SLATT_4 PF18186.1 EFE43893.1 - 0.0034 17.0 0.1 0.0047 16.6 0.1 1.2 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain family 4 Macoilin PF09726.9 EFE43893.1 - 0.0035 16.0 1.0 0.0042 15.7 1.0 1.1 1 0 0 1 1 1 1 Macoilin family bZIP_Maf PF03131.17 EFE43893.1 - 0.0089 16.5 10.5 0.0089 16.5 10.5 1.4 1 1 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.11 EFE43893.1 - 0.017 14.7 4.0 0.023 14.3 4.0 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Q_salvage PF10343.9 EFE43893.1 - 0.067 12.8 0.8 0.091 12.3 0.8 1.1 1 0 0 1 1 1 0 Potential Queuosine, Q, salvage protein family HALZ PF02183.18 EFE43893.1 - 0.072 13.3 2.1 0.13 12.5 2.1 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper HAUS5 PF14817.6 EFE43893.1 - 0.086 11.6 6.6 0.11 11.3 6.6 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 GAS PF13851.6 EFE43893.1 - 0.09 12.1 6.5 0.11 11.8 6.5 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding CLZ PF16526.5 EFE43893.1 - 0.11 12.9 3.5 0.25 11.7 3.5 1.6 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF948 PF06103.11 EFE43893.1 - 0.13 12.6 0.2 0.19 12.0 0.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) GvpL_GvpF PF06386.11 EFE43893.1 - 0.15 12.0 5.0 0.31 10.9 5.0 1.5 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF FlaC_arch PF05377.11 EFE43893.1 - 0.17 12.3 0.6 0.3 11.5 0.6 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Csm1_N PF18504.1 EFE43893.1 - 0.32 11.4 5.7 0.72 10.2 1.8 2.2 1 1 1 2 2 2 0 Csm1 N-terminal domain Wound_ind PF08186.11 EFE43894.1 - 0.023 15.1 0.4 0.037 14.4 0.4 1.3 1 0 0 1 1 1 0 Wound-inducible basic protein family DUF3464 PF11947.8 EFE43895.1 - 0.054 13.3 0.2 0.076 12.8 0.2 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DDRGK PF09756.9 EFE43895.1 - 0.18 11.4 11.8 0.23 11.0 11.8 1.1 1 0 0 1 1 1 0 DDRGK domain CDC45 PF02724.14 EFE43895.1 - 0.9 7.8 5.7 1 7.6 5.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EFE43895.1 - 0.91 8.2 2.8 1.1 8.0 2.8 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 EFE43895.1 - 1.8 8.3 5.5 2.3 8.0 5.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.8 EFE43895.1 - 6 5.7 8.5 7.4 5.3 8.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FancD2 PF14631.6 EFE43895.1 - 8.5 3.6 5.3 11 3.3 5.3 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease NPR3 PF03666.13 EFE43895.1 - 9.9 4.8 7.7 13 4.4 7.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 G-alpha PF00503.20 EFE43897.1 - 1.8e-101 339.8 0.0 2.4e-101 339.4 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFE43897.1 - 2e-13 50.2 1.3 6.3e-09 35.5 0.0 2.6 3 0 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFE43897.1 - 8.6e-07 28.5 0.1 0.001 18.5 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region BsuBI_PstI_RE PF06616.11 EFE43897.1 - 0.0017 17.7 0.1 0.0029 16.9 0.1 1.3 1 0 0 1 1 1 1 BsuBI/PstI restriction endonuclease domain Roc PF08477.13 EFE43897.1 - 0.0064 16.7 0.4 1.5 9.0 0.0 2.8 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFE43897.1 - 0.017 15.2 0.0 4.8 7.3 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase TniB PF05621.11 EFE43897.1 - 0.018 14.4 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 EFE43897.1 - 0.093 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EFE43897.1 - 0.11 11.9 0.1 0.4 10.0 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF2368 PF10166.9 EFE43898.1 - 0.18 11.4 0.7 0.41 10.3 0.2 1.7 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2368) DUF1713 PF08213.11 EFE43899.1 - 6.3e-11 42.0 22.0 1.6e-10 40.7 22.0 1.7 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) ATP-synt_C PF00137.21 EFE43900.1 - 1.3e-19 70.3 18.4 9.3e-18 64.3 7.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C p450 PF00067.22 EFE43902.1 - 8.4e-53 179.7 0.0 1.8e-51 175.4 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 CFEM PF05730.11 EFE43904.1 - 1.8e-05 24.8 6.5 4.1e-05 23.6 6.5 1.5 1 0 0 1 1 1 1 CFEM domain GSHPx PF00255.19 EFE43905.1 - 1.4e-39 134.0 0.0 1.8e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EFE43905.1 - 0.033 14.1 0.0 0.1 12.5 0.0 1.9 1 1 0 1 1 1 0 AhpC/TSA family Ral PF11058.8 EFE43905.1 - 0.11 12.1 0.1 0.22 11.1 0.1 1.5 1 0 0 1 1 1 0 Antirestriction protein Ral Hydrolase_6 PF13344.6 EFE43907.1 - 1.6e-23 82.7 0.0 3.4e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFE43907.1 - 5.2e-12 45.7 0.0 2.2e-11 43.6 0.0 2.2 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EFE43907.1 - 0.034 14.4 0.0 15 5.8 0.0 2.8 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase DUF676 PF05057.14 EFE43908.1 - 3.4e-27 95.4 0.0 5.1e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EFE43908.1 - 0.01 15.7 0.0 0.022 14.6 0.0 1.6 2 0 0 2 2 2 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 EFE43908.1 - 0.041 13.7 0.1 0.096 12.5 0.1 1.6 1 0 0 1 1 1 0 Lipase (class 3) Ribosomal_L22e PF01776.17 EFE43910.1 - 1.4e-46 157.3 0.5 1.9e-46 156.9 0.5 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family Translin PF01997.16 EFE43911.1 - 1.3e-38 133.0 0.0 1.6e-38 132.8 0.0 1.0 1 0 0 1 1 1 1 Translin family Pcc1 PF09341.10 EFE43913.1 - 3.9e-33 113.4 1.0 5.3e-33 113.0 1.0 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 DSPn PF14671.6 EFE43914.1 - 7.2e-39 133.5 0.0 5.3e-37 127.4 0.0 2.7 2 1 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EFE43914.1 - 8.1e-16 58.1 0.0 1.8e-15 56.9 0.0 1.5 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFE43914.1 - 6.5e-05 22.6 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pyridoxal_deC PF00282.19 EFE43916.1 - 7.7e-57 192.7 0.0 1.2e-56 192.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DUF917 PF06032.12 EFE43916.1 - 6.1e-49 166.7 0.0 9.6e-49 166.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF917) DUF3715 PF12509.8 EFE43916.1 - 0.04 13.9 0.0 0.081 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3715) N1221 PF07923.13 EFE43916.1 - 0.12 11.5 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 N1221-like protein Aminotran_5 PF00266.19 EFE43916.1 - 0.16 10.9 0.0 0.25 10.3 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Hydantoinase_A PF01968.18 EFE43917.1 - 1.4e-31 109.9 5.3 2.2e-26 92.8 1.0 3.3 2 1 1 3 3 3 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EFE43917.1 - 9.8e-28 97.1 2.3 2.4e-25 89.3 0.2 2.8 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region DUF917 PF06032.12 EFE43917.1 - 1.7e-12 46.8 0.2 1.4e-11 43.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF917) MutL PF13941.6 EFE43917.1 - 2e-05 23.4 3.1 0.0092 14.6 0.4 2.4 2 0 0 2 2 2 2 MutL protein BcrAD_BadFG PF01869.20 EFE43917.1 - 0.054 13.0 5.2 0.12 11.9 0.3 2.9 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Cucumo_coat PF00760.18 EFE43917.1 - 0.066 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Cucumovirus coat protein FtsA PF14450.6 EFE43917.1 - 0.089 13.2 5.6 4.9 7.6 0.3 3.4 3 1 0 3 3 3 0 Cell division protein FtsA MreB_Mbl PF06723.13 EFE43917.1 - 0.11 11.3 4.8 0.17 10.7 2.0 2.5 1 1 1 2 2 2 0 MreB/Mbl protein StbA PF06406.11 EFE43917.1 - 0.13 11.4 0.2 10 5.3 0.3 2.4 2 0 0 2 2 2 0 StbA protein Homeodomain PF00046.29 EFE43918.1 - 2.2e-12 46.7 0.0 5.5e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Homeodomain MFS_1 PF07690.16 EFE43919.1 - 7.1e-16 58.1 8.8 8.4e-16 57.8 8.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EFE43919.1 - 7.5e-06 24.5 1.1 8.9e-06 24.3 1.1 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MscS_TM PF12794.7 EFE43919.1 - 0.0012 17.8 0.1 0.0024 16.8 0.1 1.6 1 1 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 DUF3169 PF11368.8 EFE43919.1 - 0.046 13.2 0.3 0.046 13.2 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Phage_Gp23 PF10669.9 EFE43919.1 - 0.071 13.4 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Fungal_trans_2 PF11951.8 EFE43920.1 - 1.1e-51 175.8 0.1 1.5e-51 175.4 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE43920.1 - 1.2e-07 31.7 9.8 1.2e-07 31.7 9.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFE43921.1 - 4.7e-29 101.2 0.0 1e-28 100.1 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE43921.1 - 1.8e-07 31.1 8.0 1.8e-07 31.1 8.0 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 EFE43921.1 - 0.077 13.2 1.5 0.1 12.8 0.2 1.9 2 0 0 2 2 2 0 Gal4-like dimerisation domain Herpes_ICP4_N PF03584.15 EFE43921.1 - 0.16 11.8 0.0 0.71 9.7 0.0 1.9 2 0 0 2 2 2 0 Herpesvirus ICP4-like protein N-terminal region Pkinase PF00069.25 EFE43922.1 - 1e-16 61.1 0.0 1.8e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43922.1 - 0.0095 15.2 0.0 4.6 6.5 0.0 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase Atrophin-1 PF03154.15 EFE43924.1 - 0.00057 18.3 6.5 0.00057 18.3 6.5 1.2 1 0 0 1 1 1 1 Atrophin-1 family Dsh_C PF12316.8 EFE43924.1 - 0.0066 16.9 1.5 0.0094 16.4 1.5 1.4 1 0 0 1 1 1 1 Segment polarity protein dishevelled (Dsh) C terminal DUF4746 PF15928.5 EFE43924.1 - 0.031 13.7 0.3 0.035 13.5 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TraV PF09676.10 EFE43924.1 - 0.032 15.2 2.0 0.039 14.9 2.0 1.2 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Afi1 PF07792.12 EFE43924.1 - 0.068 13.7 1.1 0.086 13.3 1.1 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Connexin PF00029.19 EFE43924.1 - 0.093 12.5 1.5 0.12 12.2 1.5 1.1 1 0 0 1 1 1 0 Connexin RR_TM4-6 PF06459.12 EFE43924.1 - 0.18 11.6 6.1 0.21 11.4 6.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF908 PF06012.12 EFE43924.1 - 0.32 10.4 3.4 0.38 10.1 3.4 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) DUF2828 PF11443.8 EFE43924.1 - 0.32 9.0 3.5 0.36 8.8 3.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MCM_bind PF09739.9 EFE43924.1 - 0.36 9.2 2.7 0.38 9.1 2.7 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RNA_pol_Rpc4 PF05132.14 EFE43924.1 - 0.61 10.5 6.1 0.92 9.9 6.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Rtf2 PF04641.12 EFE43924.1 - 4.3 6.6 13.7 5.5 6.3 13.7 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Presenilin PF01080.17 EFE43924.1 - 5.4 5.7 9.2 6.7 5.4 9.2 1.0 1 0 0 1 1 1 0 Presenilin MAJIN PF15077.6 EFE43924.1 - 5.9 6.6 9.8 7.5 6.3 9.8 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein CDC45 PF02724.14 EFE43924.1 - 9 4.5 9.9 11 4.2 9.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Rrn6 PF10214.9 EFE43924.1 - 9.6 4.6 12.0 11 4.4 12.0 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor V_ATPase_I PF01496.19 EFE43924.1 - 9.9 3.9 5.2 11 3.7 5.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5585 PF17823.1 EFE43925.1 - 0.25 10.3 16.1 0.3 10.0 16.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Ank_4 PF13637.6 EFE43929.1 - 1.6e-12 47.7 0.1 1.3e-06 28.8 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFE43929.1 - 1.7e-09 38.1 0.0 2e-05 25.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFE43929.1 - 9.1e-08 31.8 0.1 1.3e-05 25.2 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFE43929.1 - 8.5e-07 29.1 0.1 1.7e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EFE43929.1 - 1.8e-06 28.1 0.6 1.2e-05 25.5 0.0 2.7 3 1 0 3 3 3 1 Ankyrin repeat KilA-N PF04383.13 EFE43929.1 - 0.00012 21.9 0.1 0.0015 18.4 0.1 2.4 1 1 0 1 1 1 1 KilA-N domain DUF4407 PF14362.6 EFE43929.1 - 0.56 9.5 8.0 7.8 5.8 8.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HALZ PF02183.18 EFE43929.1 - 1.6 9.0 5.7 17 5.7 0.6 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper GCS PF03074.16 EFE43930.1 - 1.6e-175 583.8 0.0 2.1e-175 583.4 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase DUF1560 PF07597.11 EFE43930.1 - 0.037 14.1 0.0 0.094 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1560) DUF2811 PF10929.8 EFE43930.1 - 0.12 12.7 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) CBS PF00571.28 EFE43931.1 - 2.3e-20 72.8 0.9 1.1e-05 25.7 0.0 5.4 5 0 0 5 5 5 5 CBS domain DUF2183 PF09949.9 EFE43935.1 - 3.7e-32 110.6 0.0 1.2e-31 109.0 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 EFE43935.1 - 0.01 15.3 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) DUF3885 PF13021.6 EFE43935.1 - 0.12 12.4 0.1 0.37 10.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) ADH_zinc_N_2 PF13602.6 EFE43936.1 - 1.1e-21 78.3 0.0 2.2e-21 77.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFE43936.1 - 2.1e-05 24.5 0.0 4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE43936.1 - 0.0038 17.1 0.0 0.008 16.1 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF2855 PF11017.8 EFE43936.1 - 0.059 13.1 0.0 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) GPP34 PF05719.11 EFE43937.1 - 7e-68 228.7 0.2 9e-68 228.3 0.2 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) PP-binding PF00550.25 EFE43938.1 - 1.2e-09 38.3 0.3 1.9e-09 37.7 0.3 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site Fer4 PF00037.27 EFE43939.1 - 1.5e-13 50.0 16.5 5.7e-08 32.3 3.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EFE43939.1 - 1.4e-12 48.0 10.0 2.2e-12 47.4 10.0 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EFE43939.1 - 7.3e-10 39.6 9.8 9.4e-05 23.3 0.9 2.3 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EFE43939.1 - 9.2e-10 38.5 31.2 4.6e-06 26.7 12.1 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_8 PF13183.6 EFE43939.1 - 1.5e-08 35.0 2.6 0.00033 21.0 0.2 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFE43939.1 - 2.4e-08 34.0 21.3 4.3e-06 26.8 12.2 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFE43939.1 - 3.1e-08 33.7 9.7 6.3e-08 32.7 9.7 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFE43939.1 - 1.4e-06 28.1 17.1 0.00037 20.4 5.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EFE43939.1 - 4.3e-06 26.5 11.8 0.0091 16.0 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EFE43939.1 - 7.9e-06 26.0 11.4 0.00028 21.2 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EFE43939.1 - 0.00038 20.9 11.8 0.048 14.2 12.9 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 EFE43939.1 - 0.0087 16.3 5.6 0.49 10.7 0.3 2.2 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_13 PF13370.6 EFE43939.1 - 0.059 13.9 15.0 0.69 10.5 4.3 2.6 2 1 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EFE43939.1 - 0.074 13.2 9.0 1.1 9.5 1.4 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 EFE43939.1 - 0.1 12.7 5.6 0.46 10.6 0.5 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_3 PF12798.7 EFE43939.1 - 0.21 12.6 15.5 0.39 11.7 3.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_22 PF17179.4 EFE43939.1 - 0.89 10.4 12.1 2.1 9.2 1.6 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain SURF6 PF04935.12 EFE43940.1 - 3.2e-50 170.7 32.6 3.2e-50 170.7 32.6 3.8 3 1 1 4 4 4 1 Surfeit locus protein 6 RRP14 PF15459.6 EFE43940.1 - 0.00036 21.1 5.7 0.00036 21.1 5.7 8.4 6 2 1 8 8 8 2 60S ribosome biogenesis protein Rrp14 Rick_17kDa_Anti PF05433.15 EFE43941.1 - 4e-05 23.4 11.5 4e-05 23.4 11.5 3.0 3 1 0 3 3 3 1 Glycine zipper 2TM domain Acyl_transf_3 PF01757.22 EFE43943.1 - 8.5e-39 133.6 31.6 1.1e-38 133.2 31.6 1.1 1 0 0 1 1 1 1 Acyltransferase family Gly_transf_sug PF04488.15 EFE43944.1 - 1.2e-12 48.3 0.2 2.5e-12 47.3 0.2 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Ribosomal_S2 PF00318.20 EFE43945.1 - 4.6e-65 218.9 0.0 4.8e-64 215.5 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S2 Taxilin PF09728.9 EFE43946.1 - 0.029 13.5 0.0 0.57 9.3 0.0 2.0 2 0 0 2 2 2 0 Myosin-like coiled-coil protein MIF4G PF02854.19 EFE43946.1 - 0.084 12.5 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 MIF4G domain Zn_clus PF00172.18 EFE43946.1 - 0.4 10.9 5.1 0.16 12.1 1.9 1.8 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.27 EFE43947.1 - 4.6e-50 167.5 0.1 2.1e-17 62.8 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein GTP_EFTU PF00009.27 EFE43948.1 - 6.8e-32 110.6 5.3 3.2e-30 105.1 5.3 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EFE43948.1 - 1.2e-27 96.1 3.0 2.1e-27 95.3 1.0 2.4 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EFE43948.1 - 8.6e-11 41.9 0.1 2e-10 40.8 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.15 EFE43948.1 - 3.2e-10 39.7 0.0 2.3e-09 36.9 0.0 2.5 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region GTP_EFTU_D2 PF03144.25 EFE43948.1 - 4.1e-05 23.9 0.4 0.031 14.7 0.1 2.9 2 0 0 2 2 2 2 Elongation factor Tu domain 2 Arf PF00025.21 EFE43948.1 - 8.4e-05 22.1 0.0 0.00017 21.1 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFE43948.1 - 0.00014 21.4 0.1 0.00033 20.1 0.1 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EFE43948.1 - 0.0022 17.9 4.5 0.064 13.2 0.2 2.8 2 1 1 3 3 2 2 RsgA GTPase Roc PF08477.13 EFE43948.1 - 0.011 15.9 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EFE43948.1 - 0.024 14.2 0.5 0.074 12.6 0.5 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EFE43948.1 - 0.027 14.5 0.0 5.7 7.0 0.0 2.9 1 1 1 2 2 2 0 Dynamin family Stc1 PF12898.7 EFE43948.1 - 0.089 13.4 4.5 0.21 12.2 4.5 1.6 1 0 0 1 1 1 0 Stc1 domain GTP_EFTU_D4 PF14578.6 EFE43948.1 - 0.1 12.5 0.1 0.1 12.5 0.1 2.7 3 1 0 3 3 2 0 Elongation factor Tu domain 4 PduV-EutP PF10662.9 EFE43948.1 - 0.1 12.3 0.3 0.31 10.8 0.3 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation HNH PF01844.23 EFE43950.1 - 0.0035 17.5 2.3 0.0068 16.6 2.3 1.5 1 0 0 1 1 1 1 HNH endonuclease Ceramidase_alk PF04734.13 EFE43952.1 - 1.8e-203 676.8 0.0 2.1e-203 676.6 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EFE43952.1 - 9.5e-58 194.8 0.1 1.5e-57 194.1 0.1 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal BCAS2 PF05700.11 EFE43953.1 - 2.2e-52 177.8 13.4 2.1e-30 106.0 3.5 2.0 2 0 0 2 2 2 2 Breast carcinoma amplified sequence 2 (BCAS2) DUF1206 PF06724.11 EFE43954.1 - 3.7 7.7 7.4 0.21 11.7 0.6 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) Kelch_5 PF13854.6 EFE43955.1 - 2.1e-19 69.1 8.1 3.9e-08 33.1 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EFE43955.1 - 1.7e-12 47.1 6.6 0.0094 15.9 0.2 5.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFE43955.1 - 1.7e-11 43.9 5.1 0.039 14.2 0.2 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EFE43955.1 - 9.7e-10 38.5 8.3 0.0022 18.2 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EFE43955.1 - 1.6e-06 27.6 5.2 0.052 13.1 0.2 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 EFE43955.1 - 1.8e-06 27.7 1.7 0.16 12.0 0.1 4.5 4 0 0 4 4 4 2 Kelch motif Snf7 PF03357.21 EFE43956.1 - 2.5e-32 111.8 18.0 2.5e-32 111.8 18.0 2.0 1 1 1 2 2 2 1 Snf7 Pecanex_C PF05041.15 EFE43956.1 - 0.0024 17.5 0.9 0.0033 17.0 0.9 1.1 1 0 0 1 1 1 1 Pecanex protein (C-terminus) CCDC24 PF15669.5 EFE43956.1 - 0.0028 17.6 5.3 0.0044 16.9 5.3 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family RTBV_P46 PF06216.11 EFE43956.1 - 0.75 8.6 3.2 1.1 8.1 2.7 1.4 1 1 1 2 2 2 0 Rice tungro bacilliform virus P46 protein DUF3138 PF11336.8 EFE43956.1 - 1.2 7.6 6.8 1.1 7.8 5.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Forkhead PF00250.18 EFE43957.1 - 5e-18 65.1 0.0 9.6e-18 64.2 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EFE43957.1 - 0.00014 22.1 0.0 0.00027 21.2 0.0 1.4 1 0 0 1 1 1 1 FHA domain 2OG-FeII_Oxy_3 PF13640.6 EFE43958.1 - 1.7e-09 38.4 0.0 2.7e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily cNMP_binding PF00027.29 EFE43959.1 - 6e-39 132.0 0.0 1.3e-19 70.1 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain CDC45 PF02724.14 EFE43960.1 - 0.049 11.9 0.9 0.049 11.9 0.9 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4629 PF15442.6 EFE43960.1 - 0.089 13.0 4.9 0.11 12.7 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4629) Menin PF05053.13 EFE43960.1 - 0.92 7.8 8.3 1.1 7.5 8.3 1.0 1 0 0 1 1 1 0 Menin Orbi_VP6 PF01516.16 EFE43960.1 - 2.8 7.4 6.2 3.5 7.0 6.2 1.1 1 0 0 1 1 1 0 Orbivirus helicase VP6 AMPK1_CBM PF16561.5 EFE43961.1 - 1.3e-09 38.1 0.0 0.00056 20.1 0.0 2.6 2 0 0 2 2 2 2 Glycogen recognition site of AMP-activated protein kinase DUF4058 PF13267.6 EFE43962.1 - 0.054 12.9 0.0 0.14 11.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4058) APH PF01636.23 EFE43963.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family EMC3_TMCO1 PF01956.16 EFE43964.1 - 0.0089 15.8 0.1 0.0095 15.7 0.1 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like TMEMspv1-c74-12 PF11044.8 EFE43964.1 - 0.033 14.2 0.1 0.056 13.4 0.1 1.3 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF2275 PF10039.9 EFE43964.1 - 0.067 13.3 0.1 0.081 13.0 0.1 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2275) GRP PF07172.11 EFE43964.1 - 0.088 13.5 0.1 0.11 13.2 0.1 1.2 1 0 0 1 1 1 0 Glycine rich protein family DUF4307 PF14155.6 EFE43964.1 - 0.2 11.5 7.3 1.4 8.7 2.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4307) CCB1 PF12046.8 EFE43964.1 - 3.7 6.9 6.9 10 5.4 5.9 1.8 1 1 0 1 1 1 0 Cofactor assembly of complex C subunit B EpuA PF11772.8 EFE43964.1 - 6.7 6.5 8.7 9.4 6.0 8.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta DUF1768 PF08719.11 EFE43965.1 - 8.3e-58 195.2 0.0 9.4e-58 195.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Pkinase PF00069.25 EFE43966.1 - 5e-24 85.1 0.0 9.3e-24 84.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE43966.1 - 8.3e-10 38.4 0.0 1.3e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE43966.1 - 0.00015 20.7 0.1 0.00023 20.1 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EFE43966.1 - 0.047 13.3 0.0 0.068 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 YoeB_toxin PF06769.14 EFE43966.1 - 0.073 13.1 0.0 0.34 10.9 0.0 2.1 2 0 0 2 2 2 0 YoeB-like toxin of bacterial type II toxin-antitoxin system Sugar_tr PF00083.24 EFE43967.1 - 2.1e-32 112.6 21.9 4e-25 88.6 7.3 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFE43967.1 - 3.6e-32 111.7 25.5 3.6e-32 111.7 25.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 EFE43967.1 - 0.011 14.0 0.2 0.026 12.8 0.2 1.6 1 0 0 1 1 1 0 BT1 family PAP2_3 PF14378.6 EFE43968.1 - 6.2e-19 68.4 7.5 8e-19 68.1 7.5 1.1 1 0 0 1 1 1 1 PAP2 superfamily PAP2 PF01569.21 EFE43968.1 - 6.4e-10 38.9 3.8 8.2e-10 38.6 3.8 1.2 1 0 0 1 1 1 1 PAP2 superfamily LCAT PF02450.15 EFE43969.1 - 4.1e-102 342.3 0.0 5e-102 342.0 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 EFE43969.1 - 0.00026 21.6 0.0 0.00064 20.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_2 PF01674.18 EFE43969.1 - 0.032 13.7 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) AP_endonuc_2 PF01261.24 EFE43969.1 - 0.16 11.4 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel LIDHydrolase PF10230.9 EFE43969.1 - 0.21 11.1 0.0 0.38 10.3 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Acetyltransf_1 PF00583.25 EFE43970.1 - 6.7e-19 68.3 0.0 1.1e-18 67.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE43970.1 - 6.9e-12 45.4 0.0 1e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE43970.1 - 1.5e-11 44.5 0.0 2.3e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE43970.1 - 2.4e-11 43.5 0.0 3.7e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 EFE43970.1 - 9e-08 32.9 0.0 1.2e-07 32.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EFE43970.1 - 1.5e-06 27.9 0.0 2.4e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE43970.1 - 1.4e-05 25.1 0.1 3.6e-05 23.9 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFE43970.1 - 0.0003 20.8 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 EFE43970.1 - 0.0033 17.6 0.0 0.0042 17.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EFE43970.1 - 0.029 14.3 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Mis14 PF08641.12 EFE43973.1 - 6.4e-23 81.5 7.0 1.6e-22 80.2 7.0 1.7 1 0 0 1 1 1 1 Kinetochore protein Mis14 like PPP4R2 PF09184.11 EFE43973.1 - 0.082 12.5 6.3 0.12 12.0 6.3 1.2 1 0 0 1 1 1 0 PPP4R2 CRAL_TRIO PF00650.20 EFE43974.1 - 8.3e-39 132.9 0.0 1.2e-38 132.4 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFE43974.1 - 4.9e-07 29.8 0.3 4.9e-07 29.8 0.3 2.6 3 0 0 3 3 3 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFE43974.1 - 0.00049 20.3 0.0 0.00075 19.7 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CPSF100_C PF13299.6 EFE43974.1 - 0.15 12.2 2.5 0.5 10.5 2.6 1.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_Rpc4 PF05132.14 EFE43974.1 - 0.75 10.2 5.6 1.2 9.5 5.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 CRT10 PF08728.10 EFE43975.1 - 0.92 7.6 4.2 0.98 7.5 4.2 1.0 1 0 0 1 1 1 0 CRT10 RasGAP PF00616.19 EFE43976.1 - 1.7e-57 194.5 0.1 6.6e-57 192.6 0.0 2.0 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EFE43976.1 - 2.3e-31 108.7 5.6 2.3e-31 108.7 5.6 2.3 2 0 0 2 2 2 1 RasGAP C-terminus DUF1647 PF07801.11 EFE43976.1 - 0.33 10.7 1.6 0.62 9.8 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) RsbU_N PF08673.10 EFE43976.1 - 0.62 10.2 3.9 1.1 9.4 0.3 2.8 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain PHD PF00628.29 EFE43977.1 - 2.5e-10 40.1 7.8 5.8e-10 38.9 7.8 1.7 1 0 0 1 1 1 1 PHD-finger Choline_kinase PF01633.20 EFE43977.1 - 0.063 12.9 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Chorismate_synt PF01264.21 EFE43978.1 - 3e-125 417.3 0.0 3.4e-125 417.1 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Ima1_N PF09779.9 EFE43979.1 - 1.4e-37 129.6 7.8 3.1e-37 128.5 7.8 1.6 1 0 0 1 1 1 1 Ima1 N-terminal domain DZR PF12773.7 EFE43979.1 - 0.22 11.6 4.3 5.5 7.1 0.3 2.7 2 0 0 2 2 2 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 EFE43979.1 - 0.76 9.8 3.9 0.29 11.1 0.8 1.9 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.7 EFE43979.1 - 0.85 9.6 11.1 0.063 13.3 4.3 2.5 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Alg14 PF08660.11 EFE43980.1 - 1.1e-51 175.3 0.0 1.4e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like DUF1180 PF06679.12 EFE43982.1 - 0.0016 18.9 0.2 0.0016 18.9 0.2 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF1180) Herpes_glycop_D PF01537.17 EFE43982.1 - 0.031 14.5 0.3 0.055 13.6 0.3 1.3 1 0 0 1 1 1 0 Herpesvirus glycoprotein D/GG/GX domain Kelch_6 PF13964.6 EFE43985.1 - 3.3e-05 24.0 0.9 0.31 11.4 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 EFE43985.1 - 3.9e-05 23.5 0.0 0.016 15.2 0.0 3.0 3 0 0 3 3 3 1 Kelch motif Mid2 PF04478.12 EFE43985.1 - 0.00027 20.8 0.0 0.00065 19.6 0.0 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Kelch_4 PF13418.6 EFE43985.1 - 0.0003 20.7 3.4 0.1 12.6 0.1 3.8 4 1 0 4 4 4 2 Galactose oxidase, central domain SKG6 PF08693.10 EFE43985.1 - 0.0055 16.1 4.1 0.011 15.1 4.1 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_2 PF07646.15 EFE43985.1 - 0.0066 16.4 3.0 2.3 8.3 0.0 4.1 3 0 0 3 3 3 2 Kelch motif BPL_LplA_LipB PF03099.19 EFE43986.1 - 7.9e-05 22.6 0.0 0.00015 21.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Peptidase_M36 PF02128.15 EFE43987.1 - 7.1e-158 525.6 11.6 1e-157 525.1 11.6 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EFE43987.1 - 4.4e-16 58.4 4.2 9.2e-16 57.4 4.2 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 EFE43987.1 - 0.00046 20.1 0.0 0.0014 18.5 0.0 1.9 2 0 0 2 2 2 1 Thermolysin metallopeptidase, alpha-helical domain AMP-binding PF00501.28 EFE43989.1 - 7.3e-68 229.1 0.0 1.2e-67 228.4 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE43989.1 - 4.7e-07 30.7 0.0 1e-06 29.6 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Lyase_1 PF00206.20 EFE43990.1 - 2.6e-84 283.3 0.0 4.1e-84 282.7 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 EFE43990.1 - 1.6e-23 83.2 0.1 4e-23 81.9 0.1 1.7 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal CNOT1_HEAT PF16418.5 EFE43990.1 - 0.087 12.9 0.0 0.31 11.1 0.0 1.9 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 HEAT repeat PEX11 PF05648.14 EFE43991.1 - 7.2e-52 176.1 2.9 3.6e-45 154.1 0.1 2.0 1 1 1 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Amidase PF01425.21 EFE43992.1 - 1.9e-68 231.5 0.0 1.1e-66 225.7 0.0 2.0 1 1 0 1 1 1 1 Amidase ARID PF01388.21 EFE43993.1 - 4.5e-11 43.3 0.0 1.1e-10 42.1 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain DUF3328 PF11807.8 EFE43993.1 - 0.0021 17.9 0.0 0.0069 16.2 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3328) RFX_DNA_binding PF02257.15 EFE43993.1 - 0.19 12.4 0.0 0.42 11.3 0.0 1.5 1 0 0 1 1 1 0 RFX DNA-binding domain DJ-1_PfpI PF01965.24 EFE43994.1 - 1.1e-14 54.6 0.0 1.4e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family ArfGap PF01412.18 EFE43995.1 - 5e-09 36.3 1.1 4.7e-08 33.1 1.1 2.1 1 1 0 1 1 1 1 Putative GTPase activating protein for Arf SelR PF01641.18 EFE43996.1 - 3.3e-50 169.2 0.2 4.9e-50 168.7 0.2 1.3 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 EFE43996.1 - 0.041 13.6 0.2 0.93 9.3 0.0 2.4 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 EFE43996.1 - 0.059 13.6 1.1 0.22 11.7 1.1 1.9 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF1771 PF08590.10 EFE43997.1 - 7e-11 42.3 5.0 7e-11 42.3 5.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) CUE PF02845.16 EFE43997.1 - 1.5e-08 34.2 0.2 2.1e-07 30.5 0.0 3.0 4 0 0 4 4 4 1 CUE domain Smr PF01713.21 EFE43997.1 - 1.9e-05 24.9 0.2 5.3e-05 23.5 0.2 1.8 1 0 0 1 1 1 1 Smr domain EF_assoc_2 PF08356.12 EFE43998.1 - 9.3e-35 118.5 0.0 1.8e-34 117.6 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 EFE43998.1 - 2e-30 104.2 0.5 3.4e-30 103.4 0.5 1.4 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 EFE43998.1 - 7.9e-24 84.1 0.0 1.3e-13 50.9 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFE43998.1 - 3.8e-13 49.7 0.0 2.3e-08 34.3 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFE43998.1 - 1.8e-09 37.7 0.0 3.2e-05 24.0 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_6 PF13405.6 EFE43998.1 - 7.8e-08 31.7 0.3 0.02 14.8 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EFE43998.1 - 5e-07 30.1 1.2 0.0017 18.8 0.3 3.0 3 0 0 3 3 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFE43998.1 - 5e-07 28.8 3.6 0.0058 16.1 0.1 3.0 3 0 0 3 3 2 2 EF hand AAA_29 PF13555.6 EFE43998.1 - 1.4e-05 24.7 0.1 0.016 14.9 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFE43998.1 - 1.4e-05 25.5 0.1 0.043 14.2 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain EF-hand_10 PF14788.6 EFE43998.1 - 1.9e-05 24.4 1.8 0.0051 16.7 0.2 2.4 2 0 0 2 2 2 1 EF hand Dynamin_N PF00350.23 EFE43998.1 - 0.00012 22.2 1.4 1 9.4 0.0 3.6 4 0 0 4 4 4 2 Dynamin family AAA_22 PF13401.6 EFE43998.1 - 0.00033 20.9 0.0 1.2 9.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EFE43998.1 - 0.0013 18.6 0.1 1.5 8.7 0.1 3.3 3 0 0 3 3 3 1 RsgA GTPase Viral_helicase1 PF01443.18 EFE43998.1 - 0.0029 17.4 0.2 0.11 12.2 0.0 2.7 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 EFE43998.1 - 0.0052 17.0 0.0 3.1 8.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFE43998.1 - 0.0055 17.2 0.1 2 9.0 0.1 2.7 2 0 0 2 2 2 1 AAA domain EF-hand_8 PF13833.6 EFE43998.1 - 0.0057 16.5 0.5 0.83 9.6 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair ABC_tran PF00005.27 EFE43998.1 - 0.0063 17.0 0.0 6.3 7.3 0.0 2.5 2 0 0 2 2 2 0 ABC transporter Septin PF00735.18 EFE43998.1 - 0.007 15.7 0.0 0.4 9.9 0.1 2.3 2 0 0 2 2 2 1 Septin Ploopntkinase3 PF18751.1 EFE43998.1 - 0.0077 16.2 0.0 0.73 9.7 0.0 2.2 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 NACHT PF05729.12 EFE43998.1 - 0.0081 16.1 0.1 4.8 7.1 0.0 2.7 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 EFE43998.1 - 0.0089 16.4 0.0 1.2 9.6 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 EFE43998.1 - 0.0099 15.5 0.1 3.1 7.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFE43998.1 - 0.013 15.1 0.1 0.52 9.8 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region GTP_EFTU PF00009.27 EFE43998.1 - 0.015 14.9 0.0 18 4.8 0.0 3.2 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EFE43998.1 - 0.018 15.2 0.3 4.2 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EFE43998.1 - 0.02 14.3 0.2 2.7 7.3 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 EFE43998.1 - 0.028 14.2 0.1 0.5 10.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EFE43998.1 - 0.046 13.5 2.7 3.3 7.4 0.0 3.3 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein MCM PF00493.23 EFE43998.1 - 0.056 12.5 0.0 2.9 6.9 0.1 2.4 2 0 0 2 2 2 0 MCM P-loop domain SMC_N PF02463.19 EFE43998.1 - 0.07 12.6 0.5 2.1 7.7 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_5 PF07728.14 EFE43998.1 - 0.085 12.9 0.3 26 4.8 0.0 3.0 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EFE43998.1 - 0.088 12.0 0.2 2.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) EF-hand_5 PF13202.6 EFE43998.1 - 0.12 11.9 6.6 0.88 9.2 0.3 3.0 3 0 0 3 3 2 0 EF hand IIGP PF05049.13 EFE43998.1 - 0.13 11.3 0.6 0.4 9.7 0.2 1.8 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Zeta_toxin PF06414.12 EFE43998.1 - 0.14 11.4 0.0 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 EFE43998.1 - 0.18 12.2 0.3 15 6.0 0.1 2.9 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EFE43998.1 - 0.24 11.1 0.2 4.9 6.8 0.0 2.6 3 0 0 3 3 2 0 IstB-like ATP binding protein MeaB PF03308.16 EFE43998.1 - 0.26 10.2 0.5 4.8 6.1 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ysc84 PF04366.12 EFE43999.1 - 9e-43 145.1 0.3 1.8e-42 144.1 0.3 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EFE43999.1 - 3.3e-13 49.0 0.1 1.7e-12 46.8 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EFE43999.1 - 1.7e-12 46.8 0.0 3.9e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EFE43999.1 - 4e-10 39.4 0.0 6.7e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Zds_C PF08632.10 EFE44000.1 - 5.8e-29 99.6 3.1 2e-28 97.9 1.6 2.2 2 0 0 2 2 2 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term ArAE_2_N PF10337.9 EFE44001.1 - 1.1e-17 64.2 0.1 2e-17 63.4 0.1 1.4 1 0 0 1 1 1 1 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 EFE44001.1 - 1.1e-06 28.8 12.0 1.1e-06 28.8 12.0 2.3 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_1 PF06081.11 EFE44001.1 - 3.6 7.7 17.0 0.15 12.2 9.4 2.2 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 ArAE_2 PF10334.9 EFE44002.1 - 4.5e-05 23.4 0.0 0.00016 21.6 0.0 1.7 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 TetR_C_31 PF17940.1 EFE44002.1 - 0.08 13.2 0.2 0.18 12.0 0.2 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain ANAPC4_WD40 PF12894.7 EFE44003.1 - 1.4e-07 31.7 0.0 8e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFE44003.1 - 0.00071 20.3 0.1 0.53 11.2 0.0 3.0 2 0 0 2 2 2 2 WD domain, G-beta repeat YpsA PF06908.11 EFE44003.1 - 0.074 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 YspA SLOG family Arf PF00025.21 EFE44004.1 - 3.2e-65 218.8 0.0 3.2e-56 189.5 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EFE44004.1 - 2.5e-11 43.8 0.0 4.1e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFE44004.1 - 1e-10 41.4 0.0 1.4e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFE44004.1 - 1.2e-09 37.9 0.0 1.6e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFE44004.1 - 2.6e-09 36.7 0.6 3.9e-05 23.0 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFE44004.1 - 2.3e-08 33.8 0.0 2.7e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFE44004.1 - 0.00012 22.1 0.0 0.00019 21.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EFE44004.1 - 0.054 12.8 0.1 0.079 12.3 0.1 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Pyr_redox_3 PF13738.6 EFE44005.1 - 5.6e-15 55.4 0.0 7.4e-14 51.7 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EFE44005.1 - 9.6e-15 54.0 0.0 1e-12 47.3 0.0 2.5 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EFE44005.1 - 2e-11 43.7 0.0 6.7e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE44005.1 - 1.4e-10 40.8 0.0 2.1e-07 30.4 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EFE44005.1 - 4.8e-07 29.3 0.1 2e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EFE44005.1 - 0.00029 21.0 0.3 0.0019 18.4 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EFE44005.1 - 0.0021 18.4 0.0 0.75 10.3 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_9 PF13454.6 EFE44005.1 - 0.0038 17.2 0.0 0.12 12.3 0.0 2.6 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EFE44005.1 - 0.0059 17.1 1.8 0.27 11.8 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFE44005.1 - 0.04 13.3 1.5 6 6.1 1.1 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EFE44005.1 - 0.047 12.7 0.2 0.94 8.5 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein DUF4147 PF13660.6 EFE44005.1 - 0.087 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4147) HI0933_like PF03486.14 EFE44005.1 - 0.21 10.3 2.2 2.8 6.5 0.1 2.8 3 0 0 3 3 3 0 HI0933-like protein FAD_binding_2 PF00890.24 EFE44005.1 - 0.37 9.8 1.1 14 4.6 0.2 2.4 2 0 0 2 2 2 0 FAD binding domain F-box-like PF12937.7 EFE44006.1 - 5.9e-06 26.1 1.3 2.4e-05 24.1 1.3 2.0 1 1 0 1 1 1 1 F-box-like Androgen_recep PF02166.16 EFE44006.1 - 0.054 12.4 0.3 0.074 11.9 0.3 1.1 1 0 0 1 1 1 0 Androgen receptor F-box PF00646.33 EFE44006.1 - 2.5 8.1 4.8 47 4.0 4.8 2.4 1 1 0 1 1 1 0 F-box domain TPR_1 PF00515.28 EFE44008.1 - 2.6e-35 118.8 8.1 2.4e-06 27.1 0.1 7.5 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFE44008.1 - 3.9e-33 110.9 9.3 7.2e-06 25.7 0.0 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat DnaJ PF00226.31 EFE44008.1 - 1.7e-26 92.1 4.7 1.7e-26 92.1 1.3 2.8 3 0 0 3 3 3 1 DnaJ domain TPR_19 PF14559.6 EFE44008.1 - 4.1e-25 88.1 10.7 2e-05 25.0 0.1 6.0 3 3 2 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFE44008.1 - 5.9e-21 73.4 8.9 0.00026 21.6 0.0 8.8 3 3 6 9 9 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFE44008.1 - 1.7e-20 72.4 15.9 1.3e-05 24.7 0.0 7.5 5 2 3 8 8 7 5 TPR repeat TPR_8 PF13181.6 EFE44008.1 - 4.7e-19 67.0 7.4 0.0062 16.7 0.1 7.0 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFE44008.1 - 9.9e-17 60.1 9.3 0.00097 19.4 0.2 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFE44008.1 - 5.1e-15 54.3 6.1 0.05 13.6 0.0 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFE44008.1 - 1.9e-13 50.5 9.5 0.034 14.4 0.0 5.8 4 1 0 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE44008.1 - 3.5e-13 49.6 2.2 0.00047 20.3 0.1 4.2 2 2 1 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFE44008.1 - 5.1e-13 49.0 2.9 0.002 18.2 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFE44008.1 - 3.8e-11 43.4 25.9 0.0035 18.0 0.0 6.3 6 1 2 8 8 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 EFE44008.1 - 1.3e-09 38.0 9.5 0.0035 17.9 0.0 7.7 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFE44008.1 - 5.7e-08 32.3 4.4 0.015 14.5 0.0 4.4 3 2 1 4 4 4 2 Tetratricopeptide repeat BTAD PF03704.17 EFE44008.1 - 1.8e-06 28.5 3.2 0.0005 20.5 0.5 4.0 2 2 0 3 3 3 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 EFE44008.1 - 6.6e-06 26.1 4.2 1.1 9.4 0.0 4.9 2 1 3 5 5 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EFE44008.1 - 1.3e-05 24.9 11.2 0.18 11.7 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat ChAPs PF09295.10 EFE44008.1 - 0.00017 20.7 0.1 0.13 11.2 0.0 2.6 2 1 1 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.6 EFE44008.1 - 0.00097 19.4 8.6 3.1 8.2 0.2 5.1 3 2 1 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.14 EFE44008.1 - 0.0023 17.4 0.3 4.2 6.7 0.0 3.2 3 0 0 3 3 3 1 Coatomer epsilon subunit TPR_MalT PF17874.1 EFE44008.1 - 0.0026 17.2 1.0 0.13 11.6 0.0 2.8 2 1 0 3 3 3 1 MalT-like TPR region SRP_TPR_like PF17004.5 EFE44008.1 - 0.007 16.4 0.7 1.6 8.8 0.0 2.9 2 1 0 2 2 2 1 Putative TPR-like repeat TPR_4 PF07721.14 EFE44008.1 - 0.018 15.6 10.5 0.43 11.3 0.0 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EFE44008.1 - 0.16 11.9 0.7 1.9 8.3 0.2 2.6 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal HHH_8 PF14716.6 EFE44008.1 - 0.7 10.3 4.3 1.9 8.9 0.1 3.6 4 0 0 4 4 3 0 Helix-hairpin-helix domain RPN7 PF10602.9 EFE44008.1 - 0.78 9.4 5.1 2.8 7.6 0.0 3.8 2 2 1 4 4 4 0 26S proteasome subunit RPN7 DUF627 PF04781.12 EFE44008.1 - 1.8 8.6 4.4 13 5.8 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF627) MIT PF04212.18 EFE44008.1 - 2.2 8.4 8.0 1.1 9.3 0.1 3.9 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain Protoglobin PF11563.8 EFE44012.1 - 8.1e-52 175.3 0.0 9.4e-52 175.1 0.0 1.1 1 0 0 1 1 1 1 Protoglobin CN_hydrolase PF00795.22 EFE44013.1 - 2.1e-36 125.6 0.0 3e-36 125.1 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EFE44013.1 - 8.4e-26 90.6 0.0 1.7e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 NAD synthase Pkinase PF00069.25 EFE44014.1 - 8.8e-53 179.3 0.0 1.4e-52 178.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44014.1 - 3.4e-30 105.2 0.0 6e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE44014.1 - 3.8e-07 29.7 0.0 5.9e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFE44014.1 - 0.00017 20.5 0.0 0.00026 19.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFE44014.1 - 0.16 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YL1 PF05764.13 EFE44015.1 - 0.0089 16.2 5.8 0.012 15.7 5.8 1.2 1 0 0 1 1 1 1 YL1 nuclear protein CENP-B_dimeris PF09026.10 EFE44015.1 - 0.51 10.8 6.6 0.12 12.8 2.5 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CDC45 PF02724.14 EFE44015.1 - 1.6 6.9 4.7 2 6.6 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 EFE44015.1 - 4.2 7.8 9.8 0.33 11.4 3.3 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TT_ORF2 PF02957.15 EFE44015.1 - 5.4 8.0 10.7 1 10.3 0.3 2.3 2 0 0 2 2 2 0 TT viral ORF2 GCIP PF13324.6 EFE44015.1 - 6.2 6.3 5.8 5.2 6.6 4.2 1.6 1 1 1 2 2 2 0 Grap2 and cyclin-D-interacting Spt5_N PF11942.8 EFE44015.1 - 8.1 7.5 18.1 21 6.2 18.1 1.8 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Sec39 PF08314.11 EFE44016.1 - 6.9e-253 841.5 0.0 7.9e-253 841.3 0.0 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 DUF3535 PF12054.8 EFE44017.1 - 8.9e-128 427.2 0.0 1.3e-126 423.4 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EFE44017.1 - 8.5e-64 215.5 0.0 2.3e-63 214.0 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE44017.1 - 1.8e-19 70.1 0.0 5.9e-19 68.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 EFE44017.1 - 1e-17 62.7 9.1 0.0014 18.7 0.2 9.5 12 0 0 12 12 12 4 HEAT repeat HEAT_2 PF13646.6 EFE44017.1 - 2.4e-06 27.8 5.9 0.0037 17.6 0.1 6.2 6 1 0 6 6 6 1 HEAT repeats Vac14_Fab1_bd PF12755.7 EFE44017.1 - 4e-06 27.3 0.2 0.56 10.8 0.0 4.2 3 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EFE44017.1 - 0.00048 19.8 0.0 0.13 11.8 0.0 3.8 3 1 1 4 4 4 1 CLASP N terminal HEAT_EZ PF13513.6 EFE44017.1 - 0.0011 19.4 7.8 7.6 7.1 0.0 7.0 6 1 2 8 8 8 1 HEAT-like repeat TAF6_C PF07571.13 EFE44017.1 - 0.0023 18.2 0.1 0.35 11.2 0.0 4.4 5 0 0 5 5 5 1 TAF6 C-terminal HEAT repeat domain RTP1_C1 PF10363.9 EFE44017.1 - 0.046 13.9 0.0 0.88 9.8 0.0 3.3 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Erythro_esteras PF05139.14 EFE44019.1 - 1.7e-97 327.3 0.7 3.4e-88 296.7 0.1 2.0 1 1 1 2 2 2 2 Erythromycin esterase Cofac_haem_bdg PF04187.13 EFE44019.1 - 0.0024 17.9 0.1 0.56 10.1 0.1 2.3 2 0 0 2 2 2 2 Haem-binding uptake, Tiki superfamily, ChaN Scs3p PF10261.9 EFE44021.1 - 9.2e-68 228.4 0.3 1.3e-67 227.9 0.3 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Med19 PF10278.9 EFE44023.1 - 1.9 8.4 12.6 2 8.4 12.6 1.0 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF3915 PF13054.6 EFE44023.1 - 2.3 8.2 5.9 2.5 8.1 5.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) tRNA-synt_1e PF01406.19 EFE44024.1 - 1.2e-15 57.7 0.0 1.4e-15 57.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1c PF00749.21 EFE44024.1 - 0.07 12.0 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain Fer4_12 PF13353.6 EFE44024.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain RNase_H2_suC PF08615.11 EFE44025.1 - 0.078 13.1 0.1 0.091 12.9 0.1 1.2 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Uds1 PF15456.6 EFE44025.1 - 0.11 12.6 5.3 0.082 13.1 0.7 2.2 1 1 1 2 2 2 0 Up-regulated During Septation APH PF01636.23 EFE44026.1 - 5.2e-08 33.1 0.0 1.2e-06 28.6 0.0 2.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Glyco_hydro_3_C PF01915.22 EFE44027.1 - 2.1e-52 178.1 0.0 3.8e-52 177.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFE44027.1 - 3.1e-37 128.7 0.0 6.6e-37 127.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFE44027.1 - 1.9e-12 47.1 0.0 3.7e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_47 PF01532.20 EFE44028.1 - 9e-182 605.0 0.0 1.1e-181 604.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_127 PF07944.12 EFE44028.1 - 0.001 17.7 0.0 0.078 11.5 0.0 2.2 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 SKG6 PF08693.10 EFE44029.1 - 8.5e-05 21.9 0.4 0.00019 20.8 0.4 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4381 PF14316.6 EFE44029.1 - 0.036 14.3 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Mfa_like_2 PF15415.6 EFE44029.1 - 0.044 12.7 0.0 0.066 12.1 0.0 1.2 1 0 0 1 1 1 0 Fimbrillin-like DUF936 PF06075.12 EFE44030.1 - 0.0018 17.3 1.2 0.0024 16.9 1.2 1.2 1 0 0 1 1 1 1 Plant protein of unknown function (DUF936) RNA_pol_Rpc4 PF05132.14 EFE44030.1 - 0.016 15.6 4.1 0.1 13.0 1.2 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF5327 PF17261.2 EFE44030.1 - 0.018 15.8 1.0 0.39 11.5 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5327) E1-E2_ATPase PF00122.20 EFE44030.1 - 0.027 14.0 0.1 0.049 13.1 0.1 1.4 1 0 0 1 1 1 0 E1-E2 ATPase Abhydrolase_6 PF12697.7 EFE44030.1 - 0.075 13.6 0.0 0.078 13.6 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family Connexin PF00029.19 EFE44030.1 - 0.41 10.4 4.8 1.7 8.4 0.0 2.1 1 1 1 2 2 2 0 Connexin DUF3464 PF11947.8 EFE44030.1 - 0.69 9.6 5.1 25 4.6 0.0 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Peptidase_S49_N PF08496.10 EFE44030.1 - 5.1 7.1 10.3 1.3 9.0 1.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4820 PF16091.5 EFE44030.1 - 5.8 6.2 6.8 35 3.6 7.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4820) Tombus_movement PF05318.12 EFE44030.1 - 7.6 7.5 11.4 9.2 7.2 2.4 2.2 2 0 0 2 2 2 0 Tombusvirus movement protein Fungal_trans PF04082.18 EFE44031.1 - 6.5e-24 84.4 0.0 2.8e-23 82.3 0.0 2.2 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE44031.1 - 6.5e-09 35.8 10.8 1.2e-08 35.0 10.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt20 PF12090.8 EFE44031.1 - 0.22 11.1 39.1 0.045 13.4 16.2 2.4 2 0 0 2 2 2 0 Spt20 family SUIM_assoc PF16619.5 EFE44031.1 - 1.2 9.3 27.8 2.7 8.1 12.8 3.6 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 PAT1 PF09770.9 EFE44031.1 - 1.2 7.3 28.9 0.78 7.9 12.6 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.12 EFE44031.1 - 8 6.2 17.7 2.1 8.1 3.7 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CIMR PF00878.18 EFE44033.1 - 1.8e-07 31.3 0.4 7.9e-05 22.8 0.0 2.4 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat CDC45 PF02724.14 EFE44033.1 - 2.3 6.4 4.2 3.3 5.9 4.2 1.2 1 0 0 1 1 1 0 CDC45-like protein ERG4_ERG24 PF01222.17 EFE44034.1 - 3.7e-128 427.9 2.4 4.2e-128 427.8 2.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EFE44034.1 - 0.00023 20.8 1.7 0.00048 19.7 0.5 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF1295) Ferlin_C PF16165.5 EFE44034.1 - 0.77 9.7 2.8 0.53 10.2 0.3 1.9 2 0 0 2 2 2 0 Ferlin C-terminus A_deamin PF02137.18 EFE44035.1 - 5.9e-21 75.3 0.0 3.8e-18 66.0 0.0 2.5 2 1 0 2 2 2 2 Adenosine-deaminase (editase) domain APOBEC_N PF08210.11 EFE44035.1 - 0.12 12.2 0.7 0.51 10.2 0.2 2.0 2 0 0 2 2 2 0 APOBEC-like N-terminal domain SF3b10 PF07189.11 EFE44036.1 - 1.9e-32 111.2 0.0 3.7e-32 110.3 0.0 1.5 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) IBR PF01485.21 EFE44038.1 - 8e-13 48.4 37.4 4.8e-07 29.9 10.1 3.2 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain XPG_I_2 PF12813.7 EFE44039.1 - 7.8e-76 254.8 0.0 1.1e-75 254.4 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing Inositol_P PF00459.25 EFE44040.1 - 3.4e-57 194.0 0.0 4.2e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DUF676 PF05057.14 EFE44041.1 - 3.2e-37 128.2 0.0 1.2e-35 123.0 0.0 2.8 1 1 0 1 1 1 1 Putative serine esterase (DUF676) DAGK_cat PF00781.24 EFE44041.1 - 2.7e-12 46.4 0.0 6.2e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Lipase_3 PF01764.25 EFE44041.1 - 0.18 11.7 0.0 0.42 10.5 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) WRNPLPNID PF15017.6 EFE44041.1 - 2.6 9.0 8.7 6.7 7.7 1.1 3.6 3 0 0 3 3 3 0 Putative WW-binding domain and destruction box NCA2 PF08637.10 EFE44043.1 - 9.6e-102 340.0 0.1 1.8e-101 339.1 0.1 1.5 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 Ras PF00071.22 EFE44043.1 - 2.5e-63 212.5 0.1 4.3e-63 211.7 0.1 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE44043.1 - 5.4e-33 113.8 0.0 1.2e-32 112.6 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE44043.1 - 2.1e-12 46.9 0.1 3.7e-12 46.0 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFE44043.1 - 0.00021 20.9 0.1 0.00049 19.7 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFE44043.1 - 0.00037 19.9 0.0 0.00063 19.2 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFE44043.1 - 0.017 15.1 0.2 11 5.9 0.0 2.9 3 0 0 3 3 3 0 RsgA GTPase MMR_HSR1 PF01926.23 EFE44043.1 - 0.018 15.1 0.0 0.058 13.5 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase FANCF PF11107.8 EFE44043.1 - 0.059 12.6 0.2 0.21 10.8 0.2 1.9 1 1 0 1 1 1 0 Fanconi anemia group F protein (FANCF) AAA_7 PF12775.7 EFE44043.1 - 0.063 12.8 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Dicty_REP PF05086.12 EFE44043.1 - 0.09 10.7 1.8 0.14 10.1 1.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FA_hydroxylase PF04116.13 EFE44045.1 - 2.1e-26 92.8 17.1 2.5e-26 92.6 17.1 1.1 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily AAA PF00004.29 EFE44046.1 - 7e-57 191.5 0.0 2.3e-40 138.1 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE44046.1 - 1.5e-13 50.3 1.1 8.9e-08 31.8 0.2 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EFE44046.1 - 2.7e-08 34.4 1.6 0.074 13.4 0.4 4.1 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 EFE44046.1 - 5.7e-06 26.4 0.5 0.0048 16.9 0.1 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFE44046.1 - 2e-05 24.9 0.4 0.62 10.3 0.0 3.6 2 1 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 EFE44046.1 - 3e-05 24.0 0.0 0.0099 15.7 0.0 3.0 2 1 0 2 2 2 1 Bacterial dnaA protein RuvB_N PF05496.12 EFE44046.1 - 3.2e-05 23.7 0.0 0.024 14.4 0.0 2.8 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EFE44046.1 - 0.00011 22.6 0.0 0.24 11.8 0.0 2.8 2 0 0 2 2 2 2 RNA helicase TIP49 PF06068.13 EFE44046.1 - 0.00013 21.3 0.4 0.0023 17.2 0.1 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_7 PF12775.7 EFE44046.1 - 0.00016 21.2 0.1 0.6 9.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Rad17 PF03215.15 EFE44046.1 - 0.00017 21.6 0.0 0.0021 18.0 0.0 2.2 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_2 PF07724.14 EFE44046.1 - 0.00039 20.6 0.0 0.0014 18.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 EFE44046.1 - 0.00049 20.4 0.0 1.4 9.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 EFE44046.1 - 0.00063 19.9 0.0 0.032 14.4 0.0 2.6 1 1 1 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain IstB_IS21 PF01695.17 EFE44046.1 - 0.00064 19.5 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 EFE44046.1 - 0.0011 19.1 0.0 0.34 10.9 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 EFE44046.1 - 0.0011 18.5 1.2 6.9 6.2 0.0 4.0 2 2 1 4 4 4 0 AAA domain Mg_chelatase PF01078.21 EFE44046.1 - 0.0025 17.2 2.0 0.011 15.1 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EFE44046.1 - 0.0034 16.6 0.0 2.1 7.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) NACHT PF05729.12 EFE44046.1 - 0.0067 16.4 0.1 4.8 7.1 0.1 2.7 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 EFE44046.1 - 0.012 15.4 0.9 3 7.5 0.1 3.1 3 0 0 3 3 3 0 AAA domain MCM PF00493.23 EFE44046.1 - 0.02 14.0 0.0 5.5 6.0 0.0 2.3 2 0 0 2 2 2 0 MCM P-loop domain ATPase_2 PF01637.18 EFE44046.1 - 0.024 14.5 0.4 6.2 6.7 0.1 3.1 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EFE44046.1 - 0.04 13.6 0.1 6.5 6.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.10 EFE44046.1 - 0.059 13.4 0.4 2.2 8.4 0.1 2.6 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain AAA_29 PF13555.6 EFE44046.1 - 0.11 12.2 0.2 1 9.2 0.1 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_3 PF07726.11 EFE44046.1 - 0.14 12.0 0.0 0.36 10.7 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UME PF08064.13 EFE44047.1 - 8.3e-33 112.4 0.1 6.7e-32 109.4 0.0 2.8 2 0 0 2 2 2 1 UME (NUC010) domain FAT PF02259.23 EFE44047.1 - 1.7e-31 109.7 0.0 6.5e-31 107.8 0.0 2.0 2 0 0 2 2 2 1 FAT domain TPR_14 PF13428.6 EFE44047.1 - 0.0067 17.2 0.1 12 7.0 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFE44047.1 - 0.041 14.4 0.1 18 6.0 0.0 3.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2781 PF10914.8 EFE44047.1 - 0.16 12.4 0.1 0.8 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2781) Swi3 PF07962.12 EFE44048.1 - 1.6e-18 66.4 0.0 2.6e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 RCC1 PF00415.18 EFE44049.1 - 1.7e-56 188.6 17.1 7.3e-10 39.3 0.3 8.1 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFE44049.1 - 3.8e-42 141.3 35.3 5.7e-08 32.4 1.0 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RibD_C PF01872.17 EFE44050.1 - 1e-28 100.5 0.0 1.9e-28 99.7 0.0 1.5 1 0 0 1 1 1 1 RibD C-terminal domain Nic96 PF04097.14 EFE44051.1 - 1.9e-215 717.0 0.0 6.9e-215 715.2 0.0 1.7 1 1 0 1 1 1 1 Nup93/Nic96 MFS_1 PF07690.16 EFE44052.1 - 3.7e-26 91.9 81.7 1.8e-15 56.8 47.5 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFE44052.1 - 0.00076 18.4 12.2 0.0014 17.6 12.2 1.4 1 0 0 1 1 1 1 MFS_1 like family DUF4131 PF13567.6 EFE44052.1 - 8 6.1 10.2 3.8 7.1 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Fungal_trans PF04082.18 EFE44053.1 - 8.6e-12 44.6 0.1 3.1e-11 42.8 0.0 1.8 1 1 0 2 2 2 1 Fungal specific transcription factor domain UPF0561 PF10573.9 EFE44053.1 - 0.27 11.4 0.6 0.61 10.2 0.6 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Peptidase_S10 PF00450.22 EFE44054.1 - 1.1e-26 94.2 0.0 1.3e-26 94.0 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF4545 PF15078.6 EFE44054.1 - 0.17 10.8 0.0 0.23 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4545) Peptidase_S10 PF00450.22 EFE44055.1 - 1.4e-46 159.8 0.7 2.7e-46 158.8 0.7 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase Na_Ca_ex PF01699.24 EFE44056.1 - 1.1e-23 83.9 34.7 1.5e-15 57.5 13.4 3.3 5 0 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 EFE44056.1 - 6e-15 55.7 10.9 6e-15 55.7 10.9 4.4 4 0 0 4 4 4 1 Inner membrane component domain AAA PF00004.29 EFE44057.1 - 1.9e-43 148.1 0.0 3e-43 147.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE44057.1 - 4.7e-14 51.9 0.0 1.1e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EFE44057.1 - 1.1e-07 32.1 0.0 2e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFE44057.1 - 1.7e-07 31.3 0.0 4.1e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFE44057.1 - 2.4e-06 28.0 0.1 0.00012 22.5 0.0 2.8 2 1 0 3 3 3 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 EFE44057.1 - 2.1e-05 24.4 3.6 3.1e-05 23.9 2.1 2.1 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 EFE44057.1 - 3e-05 24.3 0.2 0.0067 16.7 0.2 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFE44057.1 - 6.4e-05 22.8 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFE44057.1 - 0.001 19.6 0.1 0.019 15.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EFE44057.1 - 0.0011 18.3 0.0 0.0022 17.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EFE44057.1 - 0.0016 18.6 0.0 0.0032 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFE44057.1 - 0.0026 17.5 0.0 0.0057 16.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EFE44057.1 - 0.004 17.0 0.0 0.011 15.6 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFE44057.1 - 0.0085 15.5 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EFE44057.1 - 0.0086 15.4 0.0 0.021 14.2 0.0 1.6 1 0 0 1 1 1 1 KaiC TsaE PF02367.17 EFE44057.1 - 0.011 15.7 0.0 0.022 14.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFE44057.1 - 0.012 15.8 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EFE44057.1 - 0.024 13.8 0.0 0.043 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EFE44057.1 - 0.026 14.3 0.0 0.11 12.2 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 EFE44057.1 - 0.027 14.0 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EFE44057.1 - 0.039 14.0 0.0 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFE44057.1 - 0.039 14.3 0.0 0.071 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 EFE44057.1 - 0.039 13.4 0.0 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein HR1 PF02185.16 EFE44057.1 - 0.04 14.0 0.7 0.1 12.8 0.7 1.7 1 0 0 1 1 1 0 Hr1 repeat AAA_24 PF13479.6 EFE44057.1 - 0.043 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFE44057.1 - 0.053 13.1 0.1 0.18 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EFE44057.1 - 0.068 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EFE44057.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin F-box-like PF12937.7 EFE44058.1 - 0.04 13.8 0.1 0.14 12.1 0.1 2.0 1 0 0 1 1 1 0 F-box-like Fcf1 PF04900.12 EFE44059.1 - 2.9e-14 53.3 0.1 4.7e-06 26.9 0.1 2.5 2 0 0 2 2 2 2 Fcf1 WD40 PF00400.32 EFE44060.1 - 1.1e-14 54.5 14.8 0.00037 21.2 0.6 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 EFE44060.1 - 0.00083 18.1 4.9 0.021 13.5 0.9 2.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFE44060.1 - 0.0045 17.2 1.9 0.55 10.6 0.5 4.2 3 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4398 PF14346.6 EFE44060.1 - 0.66 10.6 9.3 1.6 9.4 9.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) Presenilin PF01080.17 EFE44061.1 - 8.6 5.0 16.5 8.9 5.0 16.5 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 EFE44061.1 - 9.3 6.0 25.9 12 5.6 25.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_S64 PF08192.11 EFE44063.1 - 5.1e-07 28.6 0.1 1e-06 27.6 0.1 1.5 1 1 0 1 1 1 1 Peptidase family S64 RRN3 PF05327.11 EFE44064.1 - 3e-167 557.5 0.0 3e-167 557.5 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 Abhydrolase_3 PF07859.13 EFE44065.1 - 2.3e-40 138.7 0.1 8.7e-31 107.4 0.2 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 EFE44065.1 - 5.1e-10 38.8 0.0 9e-10 38.0 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family DUF2974 PF11187.8 EFE44065.1 - 0.03 13.9 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Chlorophyllase2 PF12740.7 EFE44065.1 - 0.17 10.8 0.1 0.38 9.6 0.1 1.5 1 1 0 1 1 1 0 Chlorophyllase enzyme tRNA-synt_2 PF00152.20 EFE44066.1 - 6.9e-70 235.6 0.0 1e-69 235.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 EFE44066.1 - 1e-17 64.1 0.0 1.5e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 EFE44066.1 - 0.00014 21.8 0.0 0.00032 20.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFE44066.1 - 0.00088 18.8 0.0 0.99 8.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Ank_2 PF12796.7 EFE44067.1 - 1.8e-31 108.5 0.7 1.3e-09 38.5 0.1 5.3 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFE44067.1 - 4.6e-18 63.4 2.5 0.033 14.7 0.0 8.6 8 1 1 9 9 9 3 Ankyrin repeat Ank_4 PF13637.6 EFE44067.1 - 1.2e-17 64.0 2.1 0.0026 18.3 0.0 7.1 4 3 3 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EFE44067.1 - 1.9e-12 47.0 5.5 0.26 11.8 0.0 7.3 7 1 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EFE44067.1 - 4.8e-07 29.9 4.0 0.028 14.7 0.0 7.0 4 3 4 8 8 8 1 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFE44067.1 - 0.014 15.3 0.0 6.6 6.8 0.0 4.2 4 2 1 5 5 5 0 Domain of unknown function (DUF3447) VWA_3_C PF18571.1 EFE44067.1 - 0.057 13.3 2.5 21 5.1 0.0 3.8 4 0 0 4 4 4 0 von Willebrand factor type A C-terminal domain HLH PF00010.26 EFE44069.1 - 2.8e-13 49.6 0.3 2.8e-13 49.6 0.3 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Sin_N PF04801.13 EFE44069.1 - 0.51 9.5 10.1 0.059 12.6 4.3 2.1 2 0 0 2 2 2 0 Sin-like protein conserved region Septin PF00735.18 EFE44070.1 - 2.3e-08 33.7 0.0 4e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Septin HSP90 PF00183.18 EFE44071.1 - 3.8e-221 735.5 28.7 5.1e-221 735.1 28.7 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EFE44071.1 - 6.5e-15 55.6 0.1 1.2e-14 54.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFE44071.1 - 2.9e-09 36.8 0.1 1e-08 35.1 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ProQ PF04352.13 EFE44071.1 - 0.03 14.2 1.5 0.7 9.8 0.3 2.5 2 0 0 2 2 2 0 ProQ/FINO family LOH1CR12 PF10158.9 EFE44071.1 - 0.072 13.1 0.2 0.26 11.3 0.2 1.9 1 0 0 1 1 1 0 Tumour suppressor protein NTF2 PF02136.20 EFE44072.1 - 3.6e-23 82.4 0.2 5.9e-23 81.7 0.2 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EFE44072.1 - 4.6e-08 32.8 0.1 8.3e-08 31.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFE44072.1 - 0.03 14.3 0.0 0.08 13.0 0.0 1.7 1 0 0 1 1 1 0 RNA binding motif Chloroa_b-bind PF00504.21 EFE44073.1 - 0.0079 16.7 1.4 1.2 9.7 0.4 2.3 2 0 0 2 2 2 1 Chlorophyll A-B binding protein PigN PF04987.14 EFE44073.1 - 0.023 13.6 0.2 0.035 13.0 0.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) ORC3_N PF07034.11 EFE44073.1 - 0.057 12.5 1.3 0.99 8.4 0.2 2.2 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 3 N-terminus DUF997 PF06196.12 EFE44073.1 - 0.084 12.9 0.1 0.084 12.9 0.1 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF997) CrgA PF06781.12 EFE44073.1 - 0.09 12.8 0.3 0.37 10.9 0.0 2.3 2 0 0 2 2 2 0 Cell division protein CrgA PspB PF06667.12 EFE44073.1 - 0.095 12.8 0.5 0.32 11.1 0.1 2.1 2 0 0 2 2 1 0 Phage shock protein B 7tm_1 PF00001.21 EFE44073.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) CSG2 PF16965.5 EFE44073.1 - 0.14 11.1 0.2 0.21 10.5 0.0 1.4 2 0 0 2 2 2 0 Ceramide synthase regulator Scs3p PF10261.9 EFE44073.1 - 0.19 11.2 0.1 0.34 10.4 0.1 1.4 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Baculo_11_kDa PF06143.11 EFE44073.1 - 0.21 11.2 1.6 1.4 8.6 0.1 2.4 2 0 0 2 2 2 0 Baculovirus 11 kDa family SARAF PF06682.12 EFE44073.1 - 0.24 11.0 5.9 2.5 7.7 5.9 2.2 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis TRIQK PF15168.6 EFE44073.1 - 0.42 10.5 0.0 0.42 10.5 0.0 2.2 2 0 0 2 2 1 0 Triple QxxK/R motif-containing protein family DUF2207 PF09972.9 EFE44073.1 - 0.53 9.0 3.1 0.5 9.1 1.5 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF4834 PF16118.5 EFE44073.1 - 1 10.3 0.0 1 10.3 0.0 3.3 1 1 1 2 2 1 0 Domain of unknown function (DUF4834) RNA_polI_A34 PF08208.11 EFE44073.1 - 1.5 8.8 21.7 0.037 14.1 8.7 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4228 PF14009.6 EFE44073.1 - 6.2 7.2 11.3 1.8e+02 2.4 11.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4228) EphA2_TM PF14575.6 EFE44073.1 - 6.8 7.7 7.6 1.9 9.4 0.0 3.3 1 1 1 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain GRP PF07172.11 EFE44073.1 - 9.2 7.0 10.9 37 5.1 0.1 3.9 2 1 1 3 3 3 0 Glycine rich protein family PknG_rubred PF16919.5 EFE44074.1 - 0.41 10.8 2.5 7.6 6.7 2.5 2.0 1 1 0 1 1 1 0 Protein kinase G rubredoxin domain TPR_17 PF13431.6 EFE44075.1 - 7.6e-05 22.8 1.0 0.69 10.4 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFE44075.1 - 0.0025 17.4 4.7 0.2 11.4 0.0 3.9 4 0 0 4 4 4 1 TPR repeat TPR_1 PF00515.28 EFE44075.1 - 0.0041 16.9 0.4 0.51 10.2 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFE44075.1 - 0.011 15.8 0.3 0.78 10.0 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat UPF0560 PF10577.9 EFE44075.1 - 0.058 11.9 5.3 0.1 11.1 5.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Spt20 PF12090.8 EFE44075.1 - 0.072 12.7 7.1 0.14 11.8 7.1 1.5 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 EFE44075.1 - 0.091 11.6 3.0 0.15 10.9 3.0 1.2 1 0 0 1 1 1 0 Androgen receptor TPR_14 PF13428.6 EFE44075.1 - 0.11 13.3 4.4 25 6.1 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFE44075.1 - 0.16 12.3 5.6 2.2 8.7 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Nnf1 PF03980.14 EFE44076.1 - 1.1e-32 112.6 6.5 1.1e-32 112.6 6.5 2.1 1 1 1 2 2 2 1 Nnf1 DUF1887 PF09002.11 EFE44076.1 - 0.0049 15.6 0.9 0.0063 15.2 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1887) SHE3 PF17078.5 EFE44076.1 - 0.0086 15.8 1.6 0.016 15.0 1.6 1.4 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 NYD-SP28 PF14772.6 EFE44076.1 - 0.011 15.8 2.5 0.011 15.8 2.5 2.2 2 1 0 2 2 2 0 Sperm tail Cnn_1N PF07989.11 EFE44076.1 - 0.014 15.5 3.4 0.031 14.4 0.6 2.5 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF948 PF06103.11 EFE44076.1 - 0.026 14.8 0.8 0.083 13.2 0.6 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) bZIP_1 PF00170.21 EFE44076.1 - 0.026 14.6 8.5 0.16 12.1 3.6 2.6 2 0 0 2 2 2 0 bZIP transcription factor Mod_r PF07200.13 EFE44076.1 - 0.036 14.2 8.0 0.03 14.4 5.8 1.9 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Nup54 PF13874.6 EFE44076.1 - 0.047 13.8 7.6 0.036 14.2 4.6 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 MCM_N PF14551.6 EFE44076.1 - 0.048 14.2 1.0 0.085 13.4 0.8 1.6 1 1 1 2 2 2 0 MCM N-terminal domain Baculo_PEP_C PF04513.12 EFE44076.1 - 0.062 13.3 0.7 0.14 12.2 0.7 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus YkyA PF10368.9 EFE44076.1 - 0.078 12.6 7.4 0.13 11.9 7.4 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF1664 PF07889.12 EFE44076.1 - 0.08 13.0 3.9 0.19 11.8 3.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FlgN PF05130.12 EFE44076.1 - 0.086 13.3 9.3 0.059 13.9 5.9 2.2 1 1 1 3 3 3 0 FlgN protein DUF16 PF01519.16 EFE44076.1 - 0.091 13.3 3.2 0.14 12.6 3.2 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 TMPIT PF07851.13 EFE44076.1 - 0.27 10.4 3.0 0.38 10.0 3.0 1.2 1 0 0 1 1 1 0 TMPIT-like protein FlaC_arch PF05377.11 EFE44076.1 - 1 9.8 6.8 0.91 10.0 1.8 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Fungal_TACC PF12709.7 EFE44076.1 - 2 8.9 7.3 0.84 10.1 1.9 2.6 3 0 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Prefoldin_2 PF01920.20 EFE44076.1 - 3.7 7.6 10.8 0.93 9.5 4.9 2.5 2 1 0 3 3 3 0 Prefoldin subunit ZapB PF06005.12 EFE44076.1 - 7.8 7.0 12.5 0.25 11.8 4.0 2.7 2 1 1 3 3 3 0 Cell division protein ZapB FUSC PF04632.12 EFE44076.1 - 8.2 4.8 6.2 13 4.2 5.6 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family Pkinase PF00069.25 EFE44077.1 - 1.1e-69 234.8 0.0 1.7e-69 234.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44077.1 - 5.2e-33 114.4 0.0 9.4e-33 113.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFE44077.1 - 0.001 18.1 0.2 0.001 18.1 0.2 2.2 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EFE44077.1 - 0.036 13.4 0.1 0.036 13.4 0.1 2.2 2 2 1 3 3 3 0 Kinase-like APH PF01636.23 EFE44077.1 - 0.052 13.5 0.1 0.052 13.5 0.1 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family SelP_N PF04592.14 EFE44077.1 - 0.57 9.5 8.8 0.96 8.8 8.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Kdo PF06293.14 EFE44077.1 - 4.9 6.4 8.8 0.061 12.7 0.7 1.9 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family SIR2 PF02146.17 EFE44078.1 - 5.4e-35 120.9 0.0 7.7e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 Sir2 family AATase PF07247.12 EFE44079.1 - 2.9e-15 55.8 0.0 3.4e-14 52.3 0.0 2.3 1 1 0 1 1 1 1 Alcohol acetyltransferase Cation_efflux PF01545.21 EFE44080.1 - 3.5e-55 186.8 5.9 4.9e-55 186.4 5.9 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFE44080.1 - 0.00051 20.1 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter FGGY_C PF02782.16 EFE44081.1 - 1.1e-29 103.6 0.0 2.5e-29 102.4 0.0 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EFE44081.1 - 2.3e-10 40.5 0.0 2.8e-05 23.8 0.0 3.6 2 2 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Xpo1 PF08389.12 EFE44082.1 - 8.7e-38 129.7 0.9 8.7e-38 129.7 0.9 2.7 3 0 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.22 EFE44082.1 - 0.13 12.6 0.1 1.2e+02 3.4 0.0 5.1 6 0 0 6 6 6 0 HEAT repeat Esterase PF00756.20 EFE44083.1 - 3.3e-53 180.9 0.0 4e-53 180.6 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EFE44083.1 - 3.5e-05 23.4 0.1 5.4e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 EFE44083.1 - 4.8e-05 22.4 0.0 8.4e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EFE44083.1 - 0.00098 18.4 0.0 0.0023 17.2 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase_phd PF10503.9 EFE44083.1 - 0.0022 17.5 0.0 0.079 12.4 0.0 2.0 2 0 0 2 2 2 1 Esterase PHB depolymerase Lipase_3 PF01764.25 EFE44083.1 - 0.018 14.9 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 EFE44083.1 - 0.034 13.9 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Tannase PF07519.11 EFE44083.1 - 0.037 12.9 0.2 0.06 12.2 0.2 1.3 1 0 0 1 1 1 0 Tannase and feruloyl esterase Abhydrolase_2 PF02230.16 EFE44083.1 - 0.06 13.1 0.0 0.095 12.5 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EFE44083.1 - 0.091 13.3 0.0 0.098 13.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Chlorophyllase PF07224.11 EFE44083.1 - 0.094 11.7 0.0 0.32 10.0 0.0 1.7 2 0 0 2 2 2 0 Chlorophyllase Abhydrolase_3 PF07859.13 EFE44083.1 - 0.11 12.3 0.0 0.4 10.5 0.0 1.9 2 1 1 3 3 3 0 alpha/beta hydrolase fold Peptidase_C50 PF03568.17 EFE44084.1 - 1.3e-149 498.6 0.0 2.5e-149 497.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 EFE44084.1 - 0.00019 21.0 0.0 0.002 17.6 0.0 2.3 1 1 0 1 1 1 1 CHAT domain TPR_2 PF07719.17 EFE44084.1 - 0.05 13.7 1.4 19 5.7 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5321 PF17254.2 EFE44085.1 - 1.2e-49 167.9 0.1 1.4e-49 167.7 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5321) DUF2852 PF11014.8 EFE44085.1 - 0.012 15.8 0.1 0.017 15.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Muted PF14942.6 EFE44085.1 - 0.021 15.2 1.8 0.029 14.7 1.8 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF1611 PF07755.11 EFE44085.1 - 0.039 13.2 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain CREPT PF16566.5 EFE44085.1 - 0.063 13.5 0.8 0.093 12.9 0.8 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour YtpI PF14007.6 EFE44089.1 - 3.6 7.8 7.1 0.13 12.4 0.9 1.7 2 0 0 2 2 2 0 YtpI-like protein Fungal_trans PF04082.18 EFE44091.1 - 5.2e-17 61.7 0.2 1.1e-16 60.7 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE44091.1 - 8.8e-10 38.6 12.2 1.9e-09 37.4 12.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EFE44092.1 - 6.3e-20 71.4 35.8 4.8e-11 42.2 6.4 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily MFS_1_like PF12832.7 EFE44092.1 - 5.8e-06 25.4 3.7 0.014 14.2 0.1 3.3 3 0 0 3 3 3 2 MFS_1 like family MFS_2 PF13347.6 EFE44092.1 - 0.00018 20.2 6.1 0.00018 20.2 6.1 3.1 3 0 0 3 3 3 3 MFS/sugar transport protein LacY_symp PF01306.19 EFE44092.1 - 0.0044 15.8 11.3 0.023 13.5 1.7 3.1 3 0 0 3 3 3 2 LacY proton/sugar symporter Sugar_tr PF00083.24 EFE44092.1 - 0.46 9.3 14.0 0.13 11.1 1.3 3.0 3 0 0 3 3 3 0 Sugar (and other) transporter zf-rbx1 PF12678.7 EFE44093.1 - 4.5e-09 36.5 3.2 1e-08 35.3 3.2 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFE44093.1 - 1.4e-07 31.7 2.7 1.4e-07 31.7 2.7 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EFE44093.1 - 2.2e-07 30.6 0.2 4.7e-07 29.6 0.2 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE44093.1 - 5.2e-06 26.2 5.2 2.9e-05 23.8 1.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE44093.1 - 4.8e-05 23.3 0.7 0.0001 22.2 0.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFE44093.1 - 0.00012 21.8 3.1 0.00012 21.8 3.1 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE44093.1 - 0.00028 20.8 1.8 0.0016 18.4 0.5 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EFE44093.1 - 0.00059 19.4 0.7 0.0012 18.5 0.7 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EFE44093.1 - 0.0032 17.3 0.8 0.0032 17.3 0.8 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFE44093.1 - 0.004 17.2 5.2 0.068 13.2 5.2 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger YacG PF03884.14 EFE44093.1 - 0.016 14.9 0.3 0.045 13.5 0.3 1.8 1 0 0 1 1 1 0 DNA gyrase inhibitor YacG zf-RING_11 PF17123.5 EFE44093.1 - 0.17 11.7 2.5 0.73 9.6 0.2 2.4 2 0 0 2 2 2 0 RING-like zinc finger NOA36 PF06524.12 EFE44093.1 - 1.3 8.3 11.8 2.8 7.2 11.8 1.5 1 0 0 1 1 1 0 NOA36 protein zf-RING_4 PF14570.6 EFE44093.1 - 2.8 7.8 4.4 1 9.2 1.4 1.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain CENP-B_dimeris PF09026.10 EFE44093.1 - 8.1 6.9 22.6 21 5.6 0.0 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SurE PF01975.17 EFE44094.1 - 3.1e-36 125.0 0.3 3.8e-36 124.7 0.3 1.1 1 0 0 1 1 1 1 Survival protein SurE DUF3431 PF11913.8 EFE44095.1 - 4.8e-82 274.9 0.0 7e-82 274.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) MIP-T3_C PF17749.1 EFE44095.1 - 0.1 12.6 1.6 0.19 11.7 1.6 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region DUF116 PF01976.17 EFE44096.1 - 0.15 11.6 0.2 0.23 10.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF116 DnaJ PF00226.31 EFE44097.1 - 4.7e-21 74.7 1.3 1.8e-20 72.8 1.3 2.1 1 0 0 1 1 1 1 DnaJ domain Trypan_PARP PF05887.11 EFE44097.1 - 0.011 15.7 15.8 0.011 15.7 15.8 2.3 2 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) zf-B_box PF00643.24 EFE44097.1 - 0.03 14.5 2.0 0.059 13.5 2.0 1.5 1 0 0 1 1 1 0 B-box zinc finger Zn_ribbon_17 PF17120.5 EFE44097.1 - 0.041 13.5 2.2 0.072 12.7 2.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FYVE PF01363.21 EFE44097.1 - 0.53 10.5 5.5 0.39 10.9 3.2 2.0 2 0 0 2 2 2 0 FYVE zinc finger Neisseria_TspB PF05616.13 EFE44097.1 - 0.64 8.4 14.6 1.1 7.7 14.6 1.3 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein tRNA-synt_1 PF00133.22 EFE44098.1 - 6.2e-221 734.8 0.4 5.2e-220 731.8 0.4 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFE44098.1 - 1.7e-33 115.7 0.5 1.7e-33 115.7 0.5 2.3 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFE44098.1 - 3.1e-14 52.6 0.7 4.1e-07 29.1 0.0 4.4 3 2 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EFE44098.1 - 1.8e-08 34.1 3.6 2.2e-05 24.0 0.0 2.8 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 Herpes_UL56 PF04534.12 EFE44098.1 - 0.0027 17.2 0.4 0.98 8.9 0.1 2.6 2 0 0 2 2 2 2 Herpesvirus UL56 protein tRNA-synt_1e PF01406.19 EFE44098.1 - 0.0045 16.4 0.0 0.35 10.2 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain PepSY PF03413.19 EFE44098.1 - 0.095 13.3 2.6 0.21 12.2 0.0 2.7 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Pkinase PF00069.25 EFE44099.1 - 4.4e-23 82.0 0.0 3e-22 79.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44099.1 - 2.3e-06 27.1 0.2 0.0004 19.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFE44100.1 - 2e-07 30.6 0.0 8.6e-07 28.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44100.1 - 9.1e-05 21.9 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFE44101.1 - 3.4e-65 220.1 0.0 3.9e-65 219.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44101.1 - 2.1e-19 69.8 0.0 2.9e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFE44101.1 - 6e-09 36.2 0.5 0.00012 22.0 0.1 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE44101.1 - 0.0032 16.3 0.1 0.008 15.0 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFE44101.1 - 0.029 13.7 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFE44101.1 - 0.03 13.6 0.0 0.052 12.9 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 EFE44101.1 - 0.046 13.3 1.3 0.06 12.9 0.1 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase Methyltransf_2 PF00891.18 EFE44102.1 - 3.3e-25 88.6 0.0 4.9e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain FtsJ PF01728.19 EFE44102.1 - 0.012 15.8 0.0 0.035 14.2 0.0 1.8 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 EFE44102.1 - 0.016 15.9 0.0 0.045 14.5 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFE44102.1 - 0.089 13.4 0.0 0.2 12.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain AMP-binding PF00501.28 EFE44103.1 - 1.2e-47 162.5 0.0 1.6e-47 162.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Thioesterase PF00975.20 EFE44103.1 - 1.3e-27 97.4 0.0 7.9e-27 94.9 0.0 2.2 2 1 0 2 2 2 1 Thioesterase domain PP-binding PF00550.25 EFE44103.1 - 4e-10 39.9 0.0 9.3e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_1 PF00561.20 EFE44103.1 - 2.2e-06 27.5 0.0 3.8e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE44103.1 - 0.00015 22.5 0.2 0.00027 21.6 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFE44103.1 - 0.00035 19.9 0.0 0.00063 19.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Methyltransf_2 PF00891.18 EFE44104.1 - 3e-20 72.4 0.0 4.5e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain AAA_19 PF13245.6 EFE44104.1 - 0.0089 16.4 0.1 0.22 11.9 0.0 2.6 2 1 1 3 3 3 1 AAA domain Dimerisation2 PF16864.5 EFE44104.1 - 0.011 15.7 0.0 0.033 14.2 0.0 1.8 1 0 0 1 1 1 0 Dimerisation domain Uteroglobin PF01099.17 EFE44104.1 - 0.014 15.8 0.1 0.037 14.4 0.1 1.7 1 0 0 1 1 1 0 Uteroglobin family GD_AH_C PF04295.13 EFE44104.1 - 0.039 12.8 0.1 0.099 11.4 0.1 1.6 1 1 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus p450 PF00067.22 EFE44105.1 - 6e-52 176.9 0.0 2.4e-49 168.3 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 NEXCaM_BD PF16644.5 EFE44105.1 - 0.065 13.5 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin MFS_1 PF07690.16 EFE44107.1 - 1.1e-09 37.8 61.7 6.6e-08 31.9 13.4 4.4 2 2 1 3 3 3 3 Major Facilitator Superfamily NmrA PF05368.13 EFE44108.1 - 3.4e-29 102.1 0.0 1.1e-28 100.4 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFE44108.1 - 1.4e-19 70.7 0.0 2.3e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFE44108.1 - 0.038 13.4 0.0 0.13 11.7 0.0 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Latrotoxin_C PF15658.6 EFE44108.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Latrotoxin C-terminal domain p450 PF00067.22 EFE44109.1 - 1.7e-10 40.3 0.0 3e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 RNase_P_p30 PF01876.16 EFE44110.1 - 2.3e-21 76.3 0.2 3.2e-21 75.8 0.2 1.2 1 0 0 1 1 1 1 RNase P subunit p30 F-box PF00646.33 EFE44111.1 - 0.00011 21.9 0.0 0.00025 20.8 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE44111.1 - 0.00026 20.8 0.1 0.0007 19.4 0.0 1.7 2 0 0 2 2 2 1 F-box-like Abhydrolase_6 PF12697.7 EFE44112.1 - 9.5e-22 78.7 0.1 1.2e-21 78.4 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFE44112.1 - 0.01 15.3 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family PGAP1 PF07819.13 EFE44112.1 - 0.027 14.2 0.0 0.065 12.9 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein Abhydrolase_8 PF06259.12 EFE44112.1 - 0.034 13.8 0.0 0.06 13.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Hydrolase_4 PF12146.8 EFE44112.1 - 0.055 12.7 0.0 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFE44112.1 - 0.074 12.7 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EFE44112.1 - 0.19 11.5 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family A_deaminase PF00962.22 EFE44114.1 - 7.7e-123 410.0 0.0 1e-122 409.6 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF676 PF05057.14 EFE44114.1 - 0.057 12.9 0.7 1.9 8.0 0.0 2.4 1 1 0 2 2 2 0 Putative serine esterase (DUF676) UCH PF00443.29 EFE44116.1 - 9.3e-26 90.9 0.0 1.2e-25 90.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE44116.1 - 1.1e-14 54.7 0.6 1.6e-14 54.3 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EFE44116.1 - 0.00071 19.1 0.7 0.066 12.7 0.5 2.3 2 0 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase CpXC PF14353.6 EFE44116.1 - 0.015 15.3 1.0 0.13 12.3 0.0 2.2 2 0 0 2 2 2 0 CpXC protein DUF983 PF06170.12 EFE44116.1 - 0.32 11.4 0.5 9.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF983) DUF5332 PF17266.2 EFE44116.1 - 2.1 8.0 5.8 0.33 10.6 0.2 2.2 2 1 1 3 3 3 0 Family of unknown function (DUF5332) Zn-ribbon_8 PF09723.10 EFE44116.1 - 8.5 6.6 7.0 4.4 7.5 0.1 3.0 3 0 0 3 3 3 0 Zinc ribbon domain MitMem_reg PF13012.6 EFE44118.1 - 3e-36 124.2 0.1 5.5e-36 123.4 0.1 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EFE44118.1 - 1.1e-30 106.0 0.0 2.8e-30 104.7 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease tRNA_bind_2 PF13725.6 EFE44118.1 - 0.061 13.0 4.8 0.085 12.5 4.8 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain Connexin PF00029.19 EFE44118.1 - 0.56 9.9 1.7 0.92 9.2 1.7 1.3 1 0 0 1 1 1 0 Connexin ADK PF00406.22 EFE44119.1 - 1.5e-46 158.3 0.8 7.6e-46 155.9 0.1 2.0 2 0 0 2 2 2 1 Adenylate kinase ADK_lid PF05191.14 EFE44119.1 - 6.4e-17 61.2 0.0 1.5e-16 60.1 0.0 1.6 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_17 PF13207.6 EFE44119.1 - 2.7e-12 47.3 3.7 3.3e-12 47.0 1.9 2.1 1 1 1 2 2 2 1 AAA domain Mucin PF01456.17 EFE44120.1 - 0.2 11.6 5.7 0.22 11.5 5.7 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein CTD_bind PF04818.13 EFE44121.1 - 1.5e-06 28.9 0.0 6.5e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CFIA_Pcf11 PF11526.8 EFE44121.1 - 0.00077 19.9 0.7 0.0039 17.6 0.7 2.3 1 0 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 VHS PF00790.19 EFE44121.1 - 0.0023 17.8 0.0 0.0079 16.0 0.0 1.8 2 0 0 2 2 2 1 VHS domain HOOK PF05622.12 EFE44122.1 - 4.5e-23 81.3 35.3 4.5e-23 81.3 35.3 2.1 1 1 1 2 2 2 1 HOOK protein KASH_CCD PF14662.6 EFE44122.1 - 0.43 10.4 72.4 0.13 12.0 16.4 5.4 3 2 2 5 5 5 0 Coiled-coil region of CCDC155 or KASH DUF2203 PF09969.9 EFE44123.1 - 0.047 14.4 0.5 0.053 14.2 0.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Casc1 PF12366.8 EFE44123.1 - 0.1 12.1 0.5 0.11 12.0 0.5 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 Coprogen_oxidas PF01218.18 EFE44124.1 - 1.1e-135 451.1 0.0 1.2e-135 450.9 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Atg8 PF02991.16 EFE44125.1 - 1.2e-50 170.0 0.2 2e-50 169.3 0.2 1.4 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EFE44125.1 - 1e-05 25.8 0.0 1.9e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Mito_carr PF00153.27 EFE44127.1 - 5.7e-25 87.1 3.1 5.4e-15 55.1 0.1 3.3 3 1 0 3 3 3 2 Mitochondrial carrier protein Apc15p PF05841.11 EFE44128.1 - 1.4e-12 48.5 6.6 3.2e-12 47.3 0.0 2.8 3 1 0 3 3 3 2 Apc15p protein CHZ PF09649.10 EFE44129.1 - 2.5e-13 49.3 0.1 2.5e-13 49.3 0.1 2.6 3 0 0 3 3 3 1 Histone chaperone domain CHZ DUF1292 PF06949.11 EFE44129.1 - 8.4 7.4 16.6 3.1 8.8 7.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1292) HSP70 PF00012.20 EFE44130.1 - 9.1e-261 866.3 6.5 1.1e-260 866.0 6.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFE44130.1 - 4.3e-16 58.6 0.0 1.5e-15 56.8 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EFE44130.1 - 0.0033 17.2 0.0 0.011 15.5 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 EFE44130.1 - 0.015 14.6 0.1 0.031 13.6 0.1 1.5 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase FtsA PF14450.6 EFE44130.1 - 0.024 15.1 3.6 5.5 7.5 0.0 3.5 3 2 0 3 3 3 0 Cell division protein FtsA Fungal_trans PF04082.18 EFE44131.1 - 2.4e-19 69.4 0.5 3.8e-19 68.8 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain PAX PF00292.18 EFE44131.1 - 0.012 15.5 0.4 0.12 12.3 0.9 2.1 2 0 0 2 2 2 0 'Paired box' domain Zn_clus PF00172.18 EFE44131.1 - 0.013 15.6 13.4 0.024 14.7 13.4 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DIOX_N PF14226.6 EFE44132.1 - 4.6e-32 111.2 0.0 9.6e-32 110.2 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFE44132.1 - 2.2e-16 60.2 0.0 4.5e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Nop14 PF04147.12 EFE44133.1 - 0.011 14.1 0.9 0.0098 14.2 0.9 1.0 1 0 0 1 1 1 0 Nop14-like family Med8 PF10232.9 EFE44133.1 - 0.019 14.6 1.2 0.02 14.5 1.2 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 MAM PF00629.23 EFE44133.1 - 0.11 12.4 0.0 0.12 12.2 0.0 1.0 1 0 0 1 1 1 0 MAM domain, meprin/A5/mu Sporozoite_P67 PF05642.11 EFE44133.1 - 0.14 10.2 0.9 0.14 10.2 0.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CPSF100_C PF13299.6 EFE44133.1 - 0.22 11.7 2.0 0.22 11.7 2.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PAC1 PF16094.5 EFE44133.1 - 0.25 10.5 2.1 0.27 10.4 2.1 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 FAM176 PF14851.6 EFE44133.1 - 1.3 8.7 7.0 1.7 8.3 7.0 1.2 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EFE44133.1 - 7.3 4.8 7.0 7.3 4.7 7.0 1.0 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EFE44133.1 - 8.5 4.3 7.5 8.8 4.3 7.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi GATase_2 PF00310.21 EFE44134.1 - 1e-179 597.7 0.0 1.4e-179 597.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 EFE44134.1 - 3.1e-154 513.6 0.1 1.1e-153 511.8 0.0 1.9 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 EFE44134.1 - 2.4e-114 381.6 0.0 7.5e-113 376.6 0.0 2.2 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 EFE44134.1 - 2.2e-85 285.0 3.5 3.6e-85 284.4 3.5 1.3 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 EFE44134.1 - 1.4e-25 90.1 0.0 8.3e-25 87.6 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 EFE44134.1 - 4.2e-21 74.8 0.0 9.3e-21 73.7 0.0 1.6 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 EFE44134.1 - 5.4e-09 36.2 0.1 1.9e-08 34.4 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFE44134.1 - 3e-08 34.1 0.1 3.1e-05 24.4 0.0 3.3 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFE44134.1 - 2.1e-07 30.9 1.3 0.0017 18.0 0.5 2.7 2 0 0 2 2 2 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EFE44134.1 - 5.7e-07 29.2 0.1 1e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EFE44134.1 - 3.7e-06 26.4 1.0 0.032 13.5 0.0 3.3 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFE44134.1 - 1.8e-05 24.3 0.2 1.8e-05 24.3 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFE44134.1 - 4.4e-05 22.8 0.7 0.00037 19.7 0.2 2.4 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EFE44134.1 - 6e-05 21.9 0.2 6e-05 21.9 0.2 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 EFE44134.1 - 0.00034 20.0 0.0 0.00072 18.9 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 EFE44134.1 - 0.0068 15.7 0.2 0.44 9.8 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EFE44134.1 - 0.023 15.1 1.3 2.2 8.8 0.1 3.0 3 0 0 3 3 2 0 Putative NAD(P)-binding Thi4 PF01946.17 EFE44134.1 - 0.028 13.7 0.1 0.028 13.7 0.1 2.2 3 0 0 3 3 3 0 Thi4 family GIDA PF01134.22 EFE44134.1 - 0.033 13.3 2.8 0.044 12.9 0.2 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A FMO-like PF00743.19 EFE44134.1 - 0.084 11.3 0.1 0.77 8.1 0.0 2.2 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like FMN_dh PF01070.18 EFE44134.1 - 0.13 11.2 0.5 0.51 9.3 0.5 1.9 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Lycopene_cycl PF05834.12 EFE44134.1 - 0.14 11.1 0.2 0.34 9.9 0.2 1.6 1 0 0 1 1 1 0 Lycopene cyclase protein Rossmann-like PF10727.9 EFE44134.1 - 0.2 11.5 2.2 1.7 8.6 0.1 2.6 2 0 0 2 2 2 0 Rossmann-like domain AdoHcyase_NAD PF00670.21 EFE44134.1 - 0.29 11.2 1.2 30 4.6 0.0 2.8 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF3128 PF11326.8 EFE44135.1 - 3.8e-27 94.5 3.7 1e-26 93.1 3.7 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) GET2 PF08690.10 EFE44135.1 - 3.3 7.3 6.2 4.8 6.8 6.2 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 RNA12 PF10443.9 EFE44136.1 - 3e-157 523.9 1.6 6.9e-156 519.4 1.6 2.1 1 1 0 1 1 1 1 RNA12 protein ATPase_2 PF01637.18 EFE44136.1 - 0.00024 21.1 0.1 0.003 17.5 0.1 2.2 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea DUF2487 PF10673.9 EFE44136.1 - 0.0016 18.5 0.1 0.006 16.6 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2487) RRM_1 PF00076.22 EFE44136.1 - 0.0025 17.6 0.0 0.0063 16.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_16 PF13191.6 EFE44136.1 - 0.12 12.7 0.2 4.8 7.5 0.0 3.2 2 1 1 3 3 3 0 AAA ATPase domain Dehydrin PF00257.19 EFE44137.1 - 7.2 7.1 6.9 1.3 9.5 1.5 2.4 2 1 1 3 3 3 0 Dehydrin p450 PF00067.22 EFE44138.1 - 0.00075 18.4 0.0 0.0013 17.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome P450 Calpain_III PF01067.22 EFE44138.1 - 0.2 11.9 0.0 0.34 11.2 0.0 1.3 1 0 0 1 1 1 0 Calpain large subunit, domain III Mcl1_mid PF12341.8 EFE44139.1 - 2.8e-76 256.7 0.0 1.2e-43 149.6 0.0 4.2 2 2 2 4 4 4 2 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 EFE44139.1 - 2.5e-18 66.1 1.9 1.5e-08 35.2 0.1 6.6 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE44139.1 - 8.5e-17 61.2 0.0 5.5e-05 23.4 0.0 6.3 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EFE44139.1 - 3.1e-07 29.8 0.1 8e-07 28.5 0.0 1.5 1 1 1 2 2 2 1 Coatomer WD associated region eIF2A PF08662.11 EFE44139.1 - 7.4e-06 26.0 0.4 4.1e-05 23.5 0.0 2.3 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 EFE44139.1 - 0.00024 19.6 0.0 0.053 11.8 0.0 2.1 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz DNA_pol_alpha_N PF12254.8 EFE44139.1 - 0.017 15.2 3.5 0.053 13.6 3.5 1.8 1 0 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal MMS1_N PF10433.9 EFE44139.1 - 0.08 11.6 0.0 0.16 10.6 0.0 1.4 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term YbjN PF10722.9 EFE44139.1 - 0.13 12.4 0.1 0.33 11.0 0.1 1.7 1 0 0 1 1 1 0 Putative bacterial sensory transduction regulator Ge1_WD40 PF16529.5 EFE44139.1 - 0.15 11.0 0.1 4.1 6.3 0.1 2.7 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein MMU163 PF17119.5 EFE44140.1 - 1.2e-103 345.6 0.0 1.4e-103 345.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis MFS_1 PF07690.16 EFE44141.1 - 1.7e-35 122.6 18.8 1.7e-35 122.6 18.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE44141.1 - 4.2e-08 32.5 2.6 1.5e-07 30.7 2.6 1.8 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_5 PF05631.14 EFE44141.1 - 0.0033 16.4 1.0 0.0054 15.7 1.0 1.3 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM LacY_symp PF01306.19 EFE44141.1 - 0.029 13.2 0.1 0.057 12.2 0.1 1.5 1 0 0 1 1 1 0 LacY proton/sugar symporter DUF1451 PF07295.11 EFE44142.1 - 0.042 13.9 2.6 0.12 12.4 2.6 1.7 1 0 0 1 1 1 0 Zinc-ribbon containing domain DUF2347 PF09804.9 EFE44142.1 - 0.12 11.9 3.7 0.22 11.1 3.7 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) NapD PF03927.13 EFE44142.1 - 0.15 12.2 1.2 0.44 10.6 1.2 1.8 1 0 0 1 1 1 0 NapD protein DUF4298 PF14131.6 EFE44142.1 - 0.18 11.8 4.8 0.47 10.5 4.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) FAM76 PF16046.5 EFE44142.1 - 1.4 8.2 11.2 2.3 7.5 11.2 1.2 1 0 0 1 1 1 0 FAM76 protein Ax_dynein_light PF10211.9 EFE44142.1 - 2.3 8.1 11.9 4.3 7.3 11.9 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain MerR-DNA-bind PF09278.11 EFE44142.1 - 2.5 8.7 5.0 1.1 9.9 0.8 2.6 3 0 0 3 3 3 0 MerR, DNA binding VTC PF09359.10 EFE44143.1 - 1.7e-82 276.9 0.1 3.4e-82 275.9 0.1 1.5 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 EFE44143.1 - 1.4e-11 44.6 1.9 1.4e-11 44.6 1.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 EFE44143.1 - 5.2e-09 36.5 1.0 2.9e-07 30.8 0.0 4.3 2 2 2 4 4 4 2 SPX domain Cation_efflux PF01545.21 EFE44143.1 - 0.061 13.1 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 Cation efflux family RAP1 PF07218.11 EFE44143.1 - 0.1 10.9 0.1 0.18 10.1 0.1 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) 6PF2K PF01591.18 EFE44144.1 - 1.8e-67 226.9 0.0 1.7e-45 155.1 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EFE44144.1 - 7.4e-29 100.8 0.0 4.7e-22 78.6 0.0 3.0 3 0 0 3 3 3 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EFE44144.1 - 0.00037 20.7 0.0 0.13 12.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF2313 PF10076.9 EFE44144.1 - 0.061 13.2 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2313) DUF202 PF02656.15 EFE44145.1 - 0.00044 20.6 7.9 0.0033 17.8 7.9 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF202) Myelin_PLP PF01275.19 EFE44145.1 - 0.025 14.5 0.9 0.029 14.3 0.9 1.0 1 0 0 1 1 1 0 Myelin proteolipid protein (PLP or lipophilin) F-box PF00646.33 EFE44146.1 - 7e-06 25.8 0.0 1.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE44146.1 - 0.00037 20.3 0.2 0.00084 19.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like Phage_Gp23 PF10669.9 EFE44146.1 - 0.023 15.0 0.4 0.041 14.2 0.4 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) HemY_N PF07219.13 EFE44146.1 - 0.19 11.9 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 HemY protein N-terminus FMN_dh PF01070.18 EFE44147.1 - 1e-103 347.0 0.0 1.3e-103 346.7 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EFE44147.1 - 3.8e-15 55.8 0.1 4.8e-12 45.9 0.1 2.6 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.25 EFE44147.1 - 2.9e-07 29.8 0.2 0.0003 19.9 0.0 2.3 2 1 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EFE44147.1 - 3.8e-06 26.3 0.0 6.1e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EFE44147.1 - 0.011 15.2 0.6 0.051 12.9 0.1 2.0 2 0 0 2 2 2 0 Nitronate monooxygenase His_biosynth PF00977.21 EFE44147.1 - 0.036 13.5 0.0 0.075 12.5 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein Cauli_VI PF01693.16 EFE44148.1 - 1.9e-38 130.5 7.8 5.8e-20 71.3 0.6 2.4 2 0 0 2 2 2 2 Caulimovirus viroplasmin RNase_H PF00075.24 EFE44148.1 - 1.9e-35 122.1 0.0 3.2e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 RNase H YmgB PF10798.8 EFE44148.1 - 0.047 13.5 0.3 0.11 12.4 0.3 1.5 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR RVT_3 PF13456.6 EFE44148.1 - 0.048 13.5 0.0 0.14 12.0 0.0 1.8 1 1 0 1 1 1 0 Reverse transcriptase-like APH PF01636.23 EFE44150.1 - 1.2e-16 61.4 0.2 6.7e-16 58.9 0.0 2.3 2 2 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFE44150.1 - 0.028 13.7 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase DUF1679 PF07914.11 EFE44150.1 - 0.067 12.0 0.3 0.11 11.3 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) DUF4597 PF15366.6 EFE44150.1 - 0.13 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4597) FGGY_C PF02782.16 EFE44151.1 - 1.1e-70 237.5 1.5 1.3e-70 237.2 0.6 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EFE44151.1 - 4.3e-54 183.7 0.0 6.7e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain MIP PF00230.20 EFE44152.1 - 2.4e-54 184.4 0.6 3.2e-54 184.1 0.6 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF2644 PF10841.8 EFE44152.1 - 0.096 12.9 5.3 0.71 10.1 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2644) Peptidase_S8 PF00082.22 EFE44154.1 - 8e-30 104.1 1.4 1.2e-29 103.6 1.4 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE44154.1 - 1.9e-12 47.6 0.0 3.2e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 TBPIP_N PF15517.6 EFE44154.1 - 0.16 12.0 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 TBP-interacting protein N-terminus zf-BED PF02892.15 EFE44155.1 - 0.99 9.5 4.1 13 5.9 0.1 3.2 3 0 0 3 3 3 0 BED zinc finger Peptidase_S10 PF00450.22 EFE44156.1 - 7.1e-77 259.6 0.0 9.6e-77 259.1 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF3752 PF12572.8 EFE44157.1 - 4e-46 157.3 13.1 4e-46 157.3 13.1 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF3752) Cwf_Cwc_15 PF04889.12 EFE44157.1 - 3.2 7.4 27.1 0.28 10.9 12.5 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein tRNA-synt_2c PF01411.19 EFE44159.1 - 5.7e-183 609.4 1.9 9.7e-181 602.0 0.2 2.3 1 1 1 2 2 2 2 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EFE44159.1 - 4.8e-18 65.0 0.6 1.3e-17 63.6 0.6 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EFE44159.1 - 5e-14 52.9 1.6 5e-14 52.9 1.6 2.0 2 0 0 2 2 2 1 DHHA1 domain zf-RING_2 PF13639.6 EFE44161.1 - 2.2e-12 47.1 6.7 3.5e-12 46.4 6.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFE44161.1 - 8.9e-09 35.1 5.9 1.5e-08 34.4 5.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFE44161.1 - 1.4e-08 34.3 1.5 2.6e-08 33.4 1.5 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EFE44161.1 - 3.3e-08 33.3 4.0 5.4e-08 32.6 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE44161.1 - 2.4e-06 27.4 3.5 4e-06 26.7 3.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EFE44161.1 - 4.1e-06 27.0 10.0 2.1e-05 24.7 10.0 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFE44161.1 - 0.00016 21.6 0.9 0.00016 21.6 0.9 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFE44161.1 - 0.0011 18.8 2.6 0.0019 18.0 2.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFE44161.1 - 0.0026 17.8 3.2 0.0071 16.4 3.2 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EFE44161.1 - 0.015 14.9 4.1 0.026 14.1 4.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EFE44161.1 - 0.08 12.7 5.9 0.15 11.9 5.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EFE44161.1 - 0.098 12.6 5.8 0.2 11.6 5.8 1.6 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.6 EFE44161.1 - 0.16 12.1 4.9 0.36 11.0 4.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFE44161.1 - 0.22 11.4 5.8 0.75 9.7 5.8 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Apt1 PF10351.9 EFE44161.1 - 0.28 10.0 3.8 0.39 9.5 3.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain FANCL_C PF11793.8 EFE44161.1 - 0.59 10.3 4.0 2 8.6 4.0 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 EFE44161.1 - 0.6 10.3 4.1 1.4 9.1 4.1 1.7 1 1 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 EFE44161.1 - 1 9.5 4.9 2.7 8.1 4.9 1.7 1 1 0 1 1 1 0 Zinc-finger Prok-RING_1 PF14446.6 EFE44161.1 - 2.1 8.3 8.1 0.13 12.2 1.4 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DUF3844 PF12955.7 EFE44162.1 - 3.1e-36 123.7 4.3 5.7e-36 122.8 4.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) Thioredoxin_4 PF13462.6 EFE44164.1 - 1.8e-07 31.5 0.0 2.7e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin UPF0020 PF01170.18 EFE44164.1 - 0.035 13.8 0.1 0.067 12.9 0.0 1.5 1 1 1 2 2 2 0 Putative RNA methylase family UPF0020 DSBA PF01323.20 EFE44164.1 - 0.32 10.7 2.0 1.2 8.8 0.2 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain CKS PF01111.19 EFE44165.1 - 1.1e-16 60.9 0.4 5e-16 58.7 0.1 1.9 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit Bromodomain PF00439.25 EFE44166.1 - 1.5e-18 66.7 2.6 4e-10 39.6 0.0 3.3 3 0 0 3 3 3 2 Bromodomain QRPTase_C PF01729.19 EFE44166.1 - 0.02 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Staphylokinase PF02821.16 EFE44166.1 - 0.16 12.4 0.0 1.7 9.1 0.0 2.2 2 0 0 2 2 2 0 Staphylokinase/Streptokinase family HSP70 PF00012.20 EFE44167.1 - 1.4e-226 753.4 8.2 1.6e-226 753.2 8.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFE44167.1 - 6.8e-16 58.0 0.6 4.6e-15 55.3 0.3 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EFE44167.1 - 9.9e-05 22.1 0.0 0.00021 21.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EFE44167.1 - 0.03 13.3 0.1 0.39 9.7 0.1 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain DevR PF01905.16 EFE44167.1 - 0.085 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated negative auto-regulator DevR/Csa2 Activator_LAG-3 PF11498.8 EFE44167.1 - 0.2 10.6 0.0 0.59 9.0 0.0 1.6 2 0 0 2 2 2 0 Transcriptional activator LAG-3 MscS_porin PF12795.7 EFE44167.1 - 0.57 9.7 3.8 0.18 11.3 0.4 1.8 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain RRF PF01765.19 EFE44168.1 - 8.1e-47 159.2 1.0 1.1e-46 158.7 1.0 1.2 1 0 0 1 1 1 1 Ribosome recycling factor Dehalogenase PF13486.6 EFE44169.1 - 0.063 12.7 0.7 0.091 12.1 0.0 1.6 2 0 0 2 2 2 0 Reductive dehalogenase subunit TruB-C_2 PF09157.11 EFE44169.1 - 0.11 12.5 0.0 0.39 10.8 0.0 1.9 1 1 1 2 2 2 0 Pseudouridine synthase II TruB, C-terminal ANAPC_CDC26 PF10471.9 EFE44170.1 - 3.6e-20 72.6 1.0 4.4e-20 72.3 1.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 Fungal_trans PF04082.18 EFE44171.1 - 9.4e-08 31.4 0.8 1.7e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE44171.1 - 2.5e-05 24.3 7.9 4.5e-05 23.5 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FeS_assembly_P PF01883.19 EFE44172.1 - 9.4e-10 38.5 0.1 2e-09 37.5 0.1 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein FAM209 PF15206.6 EFE44172.1 - 0.032 14.0 0.0 0.032 14.0 0.0 2.4 3 0 0 3 3 3 0 FAM209 family Scs3p PF10261.9 EFE44172.1 - 0.3 10.5 0.6 0.63 9.5 0.5 1.6 1 1 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF1294 PF06961.13 EFE44172.1 - 0.57 10.5 0.1 0.57 10.5 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1294) RCR PF12273.8 EFE44172.1 - 3.8 8.2 6.3 28 5.4 6.3 2.3 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red XRN_M PF17846.1 EFE44172.1 - 3.8 6.3 5.7 5.4 5.9 5.7 1.3 1 0 0 1 1 1 0 Xrn1 helical domain adh_short_C2 PF13561.6 EFE44174.1 - 2.2e-45 155.0 2.3 7.3e-45 153.3 2.3 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE44174.1 - 8.4e-38 129.8 0.3 2.7e-37 128.1 0.3 1.8 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 EFE44174.1 - 5.5e-07 29.3 0.3 1.4e-05 24.7 0.0 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EFE44174.1 - 2.3e-05 24.7 0.0 6.2e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 EFE44174.1 - 4.9e-05 22.9 0.0 0.0015 18.0 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase KR PF08659.10 EFE44174.1 - 0.00057 19.8 0.3 0.0015 18.5 0.3 1.8 1 1 0 1 1 1 1 KR domain TrkA_N PF02254.18 EFE44174.1 - 0.0007 19.8 0.0 0.0016 18.7 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.15 EFE44174.1 - 0.016 14.4 0.0 0.026 13.7 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 EFE44174.1 - 0.028 15.0 0.5 0.074 13.6 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.19 EFE44174.1 - 0.1 11.6 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Chromate_transp PF02417.15 EFE44175.1 - 3.9e-06 27.1 0.0 5.2e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Chromate transporter Chromate_transp PF02417.15 EFE44176.1 - 1.4e-36 126.0 28.5 6.6e-35 120.6 14.0 2.5 3 0 0 3 3 3 2 Chromate transporter GTP_EFTU PF00009.27 EFE44177.1 - 1.2e-46 158.7 0.0 1.9e-46 158.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EFE44177.1 - 5.5e-37 127.1 7.8 9.7e-37 126.3 7.8 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EFE44177.1 - 3.3e-21 75.3 0.0 1e-20 73.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EFE44177.1 - 1.6e-19 69.7 0.0 5.1e-19 68.1 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFE44177.1 - 1.3e-10 41.5 0.0 3.4e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFE44177.1 - 4.1e-07 30.0 0.1 1.2e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EFE44177.1 - 1e-05 25.6 0.1 1.9e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF5505 PF17610.2 EFE44177.1 - 0.12 12.4 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5505) SRPRB PF09439.10 EFE44177.1 - 0.13 11.6 0.2 1.6 8.1 0.2 2.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PS-DH PF14765.6 EFE44178.1 - 2.5e-65 220.7 0.0 3.9e-65 220.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 EFE44178.1 - 7e-64 215.8 0.2 3e-63 213.7 0.0 2.2 3 0 0 3 3 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EFE44178.1 - 4.6e-62 209.1 0.0 3.3e-60 203.1 0.0 2.6 2 0 0 2 2 2 1 KR domain NAD_binding_4 PF07993.12 EFE44178.1 - 1e-56 192.0 0.0 1.9e-56 191.1 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein Acyl_transf_1 PF00698.21 EFE44178.1 - 1.2e-56 192.6 0.0 2e-56 191.8 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFE44178.1 - 5.5e-31 107.0 0.5 1.2e-30 105.9 0.5 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EFE44178.1 - 8.5e-18 64.9 0.0 1.8e-17 63.8 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 EFE44178.1 - 5.9e-11 42.3 0.0 6.7e-09 35.6 0.0 2.3 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Methyltransf_12 PF08242.12 EFE44178.1 - 1.5e-09 38.4 0.0 4.3e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EFE44178.1 - 3e-08 34.8 0.0 4.8e-06 27.6 0.0 2.9 1 1 1 2 2 2 1 Zinc-binding dehydrogenase 3Beta_HSD PF01073.19 EFE44178.1 - 4.6e-08 32.4 0.0 0.00016 20.8 0.0 2.8 3 0 0 3 3 3 2 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFE44178.1 - 1.4e-07 31.3 0.0 5.4e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EFE44178.1 - 1.6e-07 31.0 0.0 1e-06 28.4 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.26 EFE44178.1 - 3.8e-06 26.9 0.0 1.2e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 EFE44178.1 - 4.5e-06 27.3 0.0 3.1e-05 24.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain ADH_N PF08240.12 EFE44178.1 - 0.00011 22.0 0.0 0.00032 20.5 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short_C2 PF13561.6 EFE44178.1 - 0.00027 20.6 0.0 0.0006 19.4 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_31 PF13847.6 EFE44178.1 - 0.00066 19.5 0.0 0.0019 18.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EFE44178.1 - 0.0038 17.5 0.1 0.01 16.1 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site HipN PF18253.1 EFE44178.1 - 0.011 15.4 0.2 0.039 13.7 0.0 2.0 2 0 0 2 2 2 0 Hsp70-interacting protein N N-terminal domain TetR_C_16 PF17920.1 EFE44178.1 - 0.012 15.8 0.0 0.047 13.9 0.0 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Methyltransf_23 PF13489.6 EFE44178.1 - 0.012 15.4 0.0 0.031 14.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PUA_2 PF14306.6 EFE44178.1 - 0.051 13.3 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 PUA-like domain Alpha-E PF04168.12 EFE44178.1 - 0.15 11.8 0.0 0.37 10.5 0.0 1.5 1 0 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. Thiolase_N PF00108.23 EFE44179.1 - 2.3e-93 312.3 0.1 3.7e-93 311.6 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFE44179.1 - 2.9e-44 149.7 1.7 6.5e-44 148.5 1.1 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFE44179.1 - 1.2e-05 25.0 2.4 3.1e-05 23.7 1.4 2.2 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EFE44179.1 - 0.065 13.1 1.5 2.2 8.2 0.1 3.1 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Zip PF02535.22 EFE44180.1 - 3.5e-42 144.8 4.9 4.3e-42 144.5 4.9 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Promethin PF16015.5 EFE44180.1 - 0.31 11.0 13.4 0.99 9.4 0.5 2.9 2 0 0 2 2 2 0 Promethin DUF2401 PF10287.9 EFE44181.1 - 2.5e-75 253.0 0.0 3.9e-75 252.4 0.0 1.3 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EFE44181.1 - 1.5e-19 70.1 0.1 4e-19 68.8 0.1 1.7 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) AA_kinase PF00696.28 EFE44182.1 - 2.9e-31 108.9 0.7 4e-31 108.5 0.7 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EFE44182.1 - 2.4e-11 43.4 0.0 5.1e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 PUA domain KRE9 PF05390.11 EFE44183.1 - 3.5e-09 37.3 7.8 7.1e-09 36.3 7.8 1.5 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 EFE44183.1 - 9.5e-08 32.7 1.1 7.3e-07 29.9 0.1 2.4 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SRPRB PF09439.10 EFE44184.1 - 1.5e-26 93.0 0.1 4e-25 88.3 0.1 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EFE44184.1 - 2e-07 30.6 0.0 0.00078 18.9 0.0 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFE44184.1 - 0.0002 21.4 0.0 0.00034 20.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 EFE44184.1 - 0.026 14.2 0.6 0.25 10.9 0.6 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EFE44184.1 - 0.027 14.8 0.3 0.048 14.0 0.3 1.7 1 1 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 EFE44184.1 - 0.028 14.6 0.0 0.25 11.6 0.0 2.5 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EFE44184.1 - 0.042 13.6 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 EFE44184.1 - 0.051 13.3 0.3 0.3 10.9 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EFE44184.1 - 0.056 13.7 0.2 0.13 12.6 0.2 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFE44184.1 - 0.058 13.3 0.1 0.6 10.0 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 EFE44184.1 - 0.068 13.1 0.0 0.47 10.3 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.14 EFE44184.1 - 0.071 13.1 0.0 0.2 11.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Gtr1_RagA PF04670.12 EFE44184.1 - 0.096 12.0 0.0 0.16 11.3 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EFE44184.1 - 0.1 12.4 0.1 9 6.0 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein P2_Phage_GpR PF06891.11 EFE44184.1 - 0.16 12.1 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 P2 phage tail completion protein R (GpR) PALP PF00291.25 EFE44185.1 - 5e-56 190.3 0.0 6.4e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EFE44185.1 - 2.9e-11 43.6 0.0 5.5e-07 29.9 0.0 3.2 4 0 0 4 4 4 2 CBS domain FIST PF08495.10 EFE44185.1 - 0.13 12.3 0.2 0.64 10.0 0.2 2.3 1 1 0 1 1 1 0 FIST N domain Peptidase_M76 PF09768.9 EFE44186.1 - 4.6e-66 221.8 2.3 5.2e-66 221.6 0.9 1.6 2 0 0 2 2 2 1 Peptidase M76 family SprT-like PF10263.9 EFE44186.1 - 0.00092 19.0 0.6 0.0022 17.8 0.5 1.6 1 1 0 1 1 1 1 SprT-like family Peptidase_M91 PF14891.6 EFE44186.1 - 0.011 16.1 0.0 0.018 15.3 0.0 1.3 1 0 0 1 1 1 0 Effector protein CAF20 PF17052.5 EFE44186.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Cap associated factor Tox-MPTase2 PF15638.6 EFE44186.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 2 Pkinase PF00069.25 EFE44187.1 - 5e-70 235.9 0.0 6.1e-70 235.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44187.1 - 1.5e-42 145.7 0.0 1.9e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE44187.1 - 2.7e-07 30.2 0.0 3.7e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFE44187.1 - 0.00014 21.3 0.2 0.00022 20.7 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFE44187.1 - 0.0019 17.2 0.0 0.0025 16.8 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EFE44187.1 - 0.02 14.5 0.1 0.079 12.6 0.0 1.8 1 1 1 2 2 2 0 RIO1 family APH PF01636.23 EFE44187.1 - 0.084 12.8 0.0 0.19 11.6 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 EFE44187.1 - 0.086 12.4 0.1 0.2 11.2 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EFE44187.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL TIP41 PF04176.13 EFE44188.1 - 3.6e-68 228.4 0.0 4.8e-68 228.0 0.0 1.2 1 0 0 1 1 1 1 TIP41-like family Peptidase_M24 PF00557.24 EFE44190.1 - 9.2e-57 192.1 0.0 1.2e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFE44190.1 - 3.6e-23 81.6 0.0 6.8e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF4794 PF16042.5 EFE44192.1 - 0.069 14.1 3.6 0.082 13.9 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4794) adh_short PF00106.25 EFE44193.1 - 5.9e-22 78.1 0.0 8.6e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE44193.1 - 7.7e-11 42.0 0.0 1.1e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE44193.1 - 2.4e-07 30.9 0.0 4.4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 KR domain p450 PF00067.22 EFE44194.1 - 1.8e-63 214.9 0.0 2e-63 214.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_4 PF07993.12 EFE44195.1 - 1e-31 110.1 0.0 1.9e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EFE44195.1 - 1.1e-23 83.6 0.0 2.6e-23 82.3 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme Epimerase PF01370.21 EFE44195.1 - 3.6e-12 46.3 0.0 5.7e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PCI PF01399.27 EFE44196.1 - 6.7e-12 45.9 0.0 1.6e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.9 EFE44196.1 - 9.1e-07 28.7 0.1 1.7e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TFIIF_beta PF02270.15 EFE44197.1 - 2.5e-28 98.0 0.9 7.8e-28 96.4 0.3 2.0 2 0 0 2 2 2 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 EFE44197.1 - 2.6e-21 76.7 3.8 5.4e-10 40.1 0.2 2.6 1 1 1 2 2 2 2 TFIIF, beta subunit N-terminus Tau95 PF09734.9 EFE44197.1 - 0.014 16.2 6.6 0.11 13.3 6.6 2.2 1 1 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain zf-CCCH PF00642.24 EFE44198.1 - 5.4e-09 35.8 23.6 0.0031 17.4 0.0 5.3 5 0 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFE44198.1 - 4.5e-06 26.5 25.4 0.0068 16.4 0.5 5.9 5 1 0 5 5 5 4 Zinc finger domain zf-CCCH_3 PF15663.5 EFE44198.1 - 0.00076 19.7 11.4 0.29 11.4 2.4 3.7 2 1 1 3 3 3 3 Zinc-finger containing family Ebp2 PF05890.12 EFE44198.1 - 0.054 13.0 1.7 0.09 12.3 1.7 1.3 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 Torus PF16131.5 EFE44198.1 - 7.9 7.2 24.0 1.6 9.5 1.4 4.7 2 1 3 5 5 5 0 Torus domain bZIP_Maf PF03131.17 EFE44199.1 - 1.4e-05 25.5 15.2 1.4e-05 25.5 15.2 2.9 1 1 1 2 2 2 1 bZIP Maf transcription factor bZIP_2 PF07716.15 EFE44199.1 - 0.00021 21.3 11.6 0.00021 21.3 11.6 3.5 2 1 1 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 EFE44199.1 - 0.0048 17.0 26.8 0.024 14.7 20.7 3.3 1 1 1 2 2 2 1 bZIP transcription factor DUF1062 PF06353.12 EFE44199.1 - 0.24 12.2 9.7 1.4 9.8 8.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1062) RNA_pol_I_TF PF04090.12 EFE44200.1 - 6.7e-07 29.0 0.0 0.00036 20.1 0.0 2.3 2 0 0 2 2 2 2 RNA polymerase I specific initiation factor ECM11 PF15463.6 EFE44201.1 - 2.8e-41 141.2 0.0 7.7e-41 139.8 0.0 1.8 1 0 0 1 1 1 1 Extracellular mutant protein 11 FAM216B PF15107.6 EFE44201.1 - 0.039 13.8 0.0 0.072 13.0 0.0 1.4 1 0 0 1 1 1 0 FAM216B protein family zf-RING_2 PF13639.6 EFE44202.1 - 8.4e-07 29.2 3.9 1.4e-06 28.5 3.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFE44202.1 - 2.4e-06 27.2 5.5 4.4e-06 26.3 5.5 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EFE44202.1 - 0.0017 18.3 3.0 0.0032 17.4 3.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFE44202.1 - 0.0072 16.1 3.2 0.012 15.4 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 EFE44202.1 - 0.013 15.5 0.6 0.023 14.7 0.6 1.3 1 0 0 1 1 1 0 Zinc-finger zf-RING_5 PF14634.6 EFE44202.1 - 0.019 14.9 3.7 0.031 14.3 3.7 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 EFE44202.1 - 0.049 13.9 2.0 0.097 13.0 2.0 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 EFE44202.1 - 0.07 12.8 2.9 0.12 12.0 2.9 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 EFE44202.1 - 0.086 12.7 5.0 0.14 12.0 5.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EFE44202.1 - 0.094 12.7 3.0 0.15 12.0 3.0 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 AMP-binding PF00501.28 EFE44203.1 - 6e-71 239.2 0.0 8.3e-71 238.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EFE44203.1 - 1.3e-14 54.2 0.1 3.8e-14 52.8 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep PF00132.24 EFE44203.1 - 2e-13 49.5 0.8 3e-05 23.6 0.3 6.8 6 2 0 6 6 6 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFE44203.1 - 3.5e-08 33.1 13.6 0.01 15.5 0.1 5.2 4 1 1 5 5 5 4 Hexapeptide repeat of succinyl-transferase PUNUT PF16913.5 EFE44203.1 - 4 6.6 7.4 0.23 10.6 0.1 2.5 3 0 0 3 3 3 0 Purine nucleobase transmembrane transport MFS_1 PF07690.16 EFE44204.1 - 3.5e-42 144.6 50.4 8.2e-42 143.4 47.0 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE44204.1 - 6.8e-20 71.0 24.7 1.2e-19 70.2 24.7 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFE44204.1 - 6.9e-12 45.0 16.8 6.9e-12 45.0 16.8 3.3 2 1 1 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 EFE44204.1 - 0.005 15.2 12.7 0.14 10.4 4.1 2.5 2 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Fungal_trans_2 PF11951.8 EFE44206.1 - 1.6e-11 43.6 3.3 2.4e-11 43.1 3.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DEAD PF00270.29 EFE44207.1 - 4e-26 91.8 0.0 6.5e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EFE44207.1 - 6.9e-18 65.2 0.0 2.3e-17 63.5 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EFE44207.1 - 9.6e-14 51.7 0.1 3.4e-12 46.7 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE44207.1 - 0.00013 22.0 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 EFE44207.1 - 0.00021 21.7 0.0 0.00038 20.8 0.0 1.5 1 0 0 1 1 1 1 DNA replication factor CDT1 like PI3_PI4_kinase PF00454.27 EFE44208.1 - 0.074 12.8 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase R3H-assoc PF13902.6 EFE44208.1 - 0.084 13.3 0.6 0.16 12.3 0.6 1.4 1 0 0 1 1 1 0 R3H-associated N-terminal domain Ran_BP1 PF00638.18 EFE44209.1 - 8.4e-15 55.1 0.0 2e-08 34.5 0.2 2.4 2 0 0 2 2 2 2 RanBP1 domain HSP70 PF00012.20 EFE44210.1 - 8.6e-06 24.2 0.0 0.00081 17.7 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein YabA PF06156.13 EFE44211.1 - 0.026 15.1 0.4 0.49 11.1 0.3 2.5 2 0 0 2 2 2 0 Initiation control protein YabA ADIP PF11559.8 EFE44211.1 - 0.031 14.4 2.9 0.07 13.2 2.9 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding bZIP_2 PF07716.15 EFE44211.1 - 1.3 9.2 10.3 2 8.5 0.1 3.0 2 1 1 3 3 3 0 Basic region leucine zipper MIP-T3_C PF17749.1 EFE44211.1 - 1.4 8.9 4.8 15 5.6 0.5 2.7 3 0 0 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region MMR_HSR1 PF01926.23 EFE44212.1 - 1.8e-09 37.6 1.9 2.2e-08 34.2 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFE44212.1 - 1.5e-08 34.3 0.0 3.5e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 AIG1 family Septin PF00735.18 EFE44212.1 - 0.00044 19.6 0.0 0.00044 19.6 0.0 2.2 2 1 0 2 2 2 1 Septin RsgA_GTPase PF03193.16 EFE44212.1 - 0.00065 19.6 0.2 0.00065 19.6 0.2 2.3 3 1 0 3 3 3 1 RsgA GTPase FeoB_N PF02421.18 EFE44212.1 - 0.0012 18.4 0.3 0.0028 17.2 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFE44212.1 - 0.0012 18.9 14.0 0.0084 16.2 0.0 3.9 2 2 2 4 4 3 2 Dynamin family SRPRB PF09439.10 EFE44212.1 - 0.0028 17.1 0.1 0.01 15.2 0.1 1.9 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Viral_helicase1 PF01443.18 EFE44212.1 - 0.0087 15.8 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase IIGP PF05049.13 EFE44212.1 - 0.0096 15.0 0.0 0.021 13.9 0.0 1.6 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_22 PF13401.6 EFE44212.1 - 0.014 15.6 2.7 0.018 15.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EFE44212.1 - 0.023 13.9 0.0 0.023 13.9 0.0 2.1 3 0 0 3 3 3 0 NB-ARC domain DUF4407 PF14362.6 EFE44212.1 - 0.085 12.2 12.5 0.15 11.4 12.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ABC_tran PF00005.27 EFE44212.1 - 0.088 13.3 0.0 0.088 13.3 0.0 2.7 2 1 0 2 2 1 0 ABC transporter AAA_29 PF13555.6 EFE44212.1 - 0.098 12.4 0.8 0.35 10.7 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain Fzo_mitofusin PF04799.13 EFE44212.1 - 0.51 9.9 11.4 0.09 12.3 2.4 2.5 1 1 1 2 2 2 0 fzo-like conserved region SRP54 PF00448.22 EFE44212.1 - 1.4 8.5 5.1 12 5.5 0.0 3.1 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain KfrA_N PF11740.8 EFE44212.1 - 4.1 8.1 15.8 0.37 11.5 9.6 2.3 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term Exonuc_VII_L PF02601.15 EFE44212.1 - 7.1 6.1 13.9 11 5.5 13.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit GTP_EFTU PF00009.27 EFE44212.1 - 9.2 5.7 10.5 0.21 11.1 0.7 3.0 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain Cu-oxidase_2 PF07731.14 EFE44213.1 - 2.1e-42 144.1 5.2 2.1e-35 121.4 0.0 4.2 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EFE44213.1 - 1.1e-35 122.2 0.7 3.5e-34 117.4 1.8 2.5 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 EFE44213.1 - 6.9e-26 91.3 0.0 2.3e-25 89.6 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase IBR PF01485.21 EFE44215.1 - 0.0058 16.8 6.7 0.0058 16.8 6.7 5.1 5 1 0 5 5 5 3 IBR domain, a half RING-finger domain DMA PF03474.14 EFE44215.1 - 0.15 11.7 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 DMRTA motif Dicty_REP PF05086.12 EFE44215.1 - 0.24 9.3 0.6 0.4 8.6 0.6 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein adh_short PF00106.25 EFE44216.1 - 5.5e-78 260.9 6.1 8.7e-43 146.0 0.3 2.6 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFE44216.1 - 6.4e-61 205.9 3.6 5e-34 117.9 0.2 2.7 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 EFE44216.1 - 2.6e-32 111.0 0.0 5e-32 110.0 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 EFE44216.1 - 2.9e-23 82.7 4.2 1.5e-10 41.3 0.2 3.0 2 2 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 EFE44216.1 - 7.1e-05 22.2 0.6 0.011 15.1 0.6 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 EFE44216.1 - 1.5 8.7 5.5 14 5.5 0.2 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF543 PF04418.12 EFE44216.1 - 3.7 7.6 5.4 20 5.3 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF543) RAB3GAP2_C PF14656.6 EFE44217.1 - 0.13 10.5 0.0 0.17 10.1 0.0 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus LysM PF01476.20 EFE44218.1 - 0.093 12.8 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 LysM domain Fungal_trans PF04082.18 EFE44219.1 - 4.4e-36 124.3 0.0 2.8e-35 121.7 0.0 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain FAM176 PF14851.6 EFE44219.1 - 0.02 14.6 0.6 0.02 14.6 0.6 3.3 3 0 0 3 3 3 0 FAM176 family EPL1 PF10513.9 EFE44219.1 - 7.2 7.0 17.0 2.3 8.6 1.1 3.3 3 0 0 3 3 3 0 Enhancer of polycomb-like Glyco_hydro_18 PF00704.28 EFE44221.1 - 4.2e-33 115.4 0.0 6.1e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Hce2 PF14856.6 EFE44221.1 - 4.3e-26 91.2 0.2 1.7e-25 89.3 0.2 2.1 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor LysM PF01476.20 EFE44221.1 - 7.2e-06 26.0 2.2 0.12 12.4 0.1 3.0 3 0 0 3 3 3 2 LysM domain Chitin_bind_1 PF00187.19 EFE44221.1 - 1.7e-05 25.2 10.5 7.1e-05 23.2 10.5 2.1 1 0 0 1 1 1 1 Chitin recognition protein PigN PF04987.14 EFE44223.1 - 1.5e-161 538.3 30.0 1.5e-161 538.3 30.0 1.6 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Csm1 PF12539.8 EFE44223.1 - 1.5e-28 99.2 0.1 4.8e-28 97.6 0.1 1.9 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 Phosphodiest PF01663.22 EFE44223.1 - 1.7e-09 37.8 3.5 6e-08 32.7 3.2 2.4 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFE44223.1 - 1.5e-08 34.4 0.0 2.7e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Sulfatase V_ATPase_I PF01496.19 EFE44223.1 - 0.0016 16.5 8.8 0.0032 15.5 8.8 1.4 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Atg14 PF10186.9 EFE44223.1 - 0.0018 17.4 11.8 0.0033 16.6 11.8 1.4 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 PKcGMP_CC PF16808.5 EFE44223.1 - 0.0096 15.8 4.0 0.034 14.0 4.0 1.9 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase TolA_bind_tri PF16331.5 EFE44223.1 - 0.016 15.3 11.3 0.045 13.8 11.2 1.7 1 1 0 1 1 1 0 TolA binding protein trimerisation Spc7 PF08317.11 EFE44223.1 - 0.024 13.5 16.8 0.044 12.7 16.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EFE44223.1 - 0.044 13.9 19.3 0.13 12.3 19.3 1.8 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Prominin PF05478.11 EFE44223.1 - 0.12 10.3 8.0 0.18 9.7 8.0 1.2 1 0 0 1 1 1 0 Prominin EzrA PF06160.12 EFE44223.1 - 0.17 10.0 11.0 0.27 9.4 11.0 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Filament PF00038.21 EFE44223.1 - 0.25 10.9 16.6 0.019 14.5 10.7 1.9 2 0 0 2 2 2 0 Intermediate filament protein Allexi_40kDa PF05549.11 EFE44223.1 - 0.27 10.7 6.6 0.52 9.8 6.6 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein Exonuc_VII_L PF02601.15 EFE44223.1 - 0.28 10.7 9.7 0.57 9.7 9.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2203 PF09969.9 EFE44223.1 - 0.35 11.6 6.8 0.95 10.2 5.2 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Macoilin PF09726.9 EFE44223.1 - 0.38 9.3 22.5 0.66 8.5 22.5 1.3 1 0 0 1 1 1 0 Macoilin family Baculo_PEP_C PF04513.12 EFE44223.1 - 0.5 10.4 6.6 1.1 9.3 6.6 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc42p PF11544.8 EFE44223.1 - 0.69 9.9 8.5 0.22 11.6 4.6 2.2 1 1 1 2 2 2 0 Spindle pole body component Spc42p Erp_C PF06780.11 EFE44223.1 - 0.91 9.5 4.3 4.4 7.3 0.5 2.5 1 1 1 2 2 2 0 Erp protein C-terminus APG6_N PF17675.1 EFE44223.1 - 1.1 9.8 18.1 3.4 8.2 18.1 1.9 1 0 0 1 1 1 0 Apg6 coiled-coil region MscS_porin PF12795.7 EFE44223.1 - 1.1 8.7 26.8 0.043 13.4 20.3 1.8 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Rootletin PF15035.6 EFE44223.1 - 1.5 8.8 15.4 3.3 7.7 15.4 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion CREPT PF16566.5 EFE44223.1 - 2.3 8.4 11.2 5.2 7.2 11.2 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour CENP-O PF09496.10 EFE44223.1 - 2.4 8.1 9.6 4.1 7.3 5.4 2.3 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component DUF3450 PF11932.8 EFE44223.1 - 3 7.1 15.4 6.4 6.0 15.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) MCU PF04678.13 EFE44223.1 - 3.1 7.9 7.8 7.3 6.7 7.8 1.6 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF3138 PF11336.8 EFE44223.1 - 3.5 6.1 7.2 6 5.4 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) CorA PF01544.18 EFE44223.1 - 5.8 6.1 5.6 13 5.0 5.6 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Nup88 PF10168.9 EFE44223.1 - 9.1 3.9 10.1 13 3.4 10.1 1.1 1 0 0 1 1 1 0 Nuclear pore component AAA PF00004.29 EFE44224.1 - 4.4e-37 127.5 0.1 1.3e-36 125.9 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFE44224.1 - 3.8e-08 33.0 0.0 9.8e-08 31.7 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFE44224.1 - 1.4e-05 25.1 0.1 0.00022 21.2 0.1 2.9 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFE44224.1 - 1.7e-05 25.3 0.8 0.00039 20.8 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EFE44224.1 - 2.7e-05 24.0 0.0 5.7e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EFE44224.1 - 3.5e-05 23.8 0.0 9e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EFE44224.1 - 0.0002 21.5 0.0 0.00051 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFE44224.1 - 0.00031 21.0 0.1 0.0043 17.3 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFE44224.1 - 0.00055 20.1 0.0 0.0012 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFE44224.1 - 0.00064 20.3 0.1 0.0025 18.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFE44224.1 - 0.00075 19.3 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EFE44224.1 - 0.0011 18.4 0.1 0.002 17.5 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EFE44224.1 - 0.0011 18.6 0.1 0.027 14.0 0.1 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFE44224.1 - 0.0015 18.9 0.0 0.0049 17.2 0.0 2.0 1 1 1 2 2 2 1 RNA helicase TniB PF05621.11 EFE44224.1 - 0.003 17.0 0.0 2.9 7.3 0.0 2.5 1 1 1 2 2 2 2 Bacterial TniB protein NACHT PF05729.12 EFE44224.1 - 0.0043 17.0 0.1 0.015 15.2 0.0 2.0 2 1 0 2 2 2 1 NACHT domain Parvo_NS1 PF01057.17 EFE44224.1 - 0.0046 16.1 0.0 0.008 15.3 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 EFE44224.1 - 0.0084 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EFE44224.1 - 0.0089 15.7 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EFE44224.1 - 0.0092 16.1 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_28 PF13521.6 EFE44224.1 - 0.0092 16.2 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFE44224.1 - 0.011 15.6 0.6 0.17 11.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFE44224.1 - 0.011 15.6 0.1 0.038 13.9 0.0 1.8 1 1 1 2 2 2 0 Rad17 P-loop domain ABC_tran PF00005.27 EFE44224.1 - 0.025 15.1 0.3 0.087 13.3 0.0 2.1 2 1 0 2 2 2 0 ABC transporter DUF815 PF05673.13 EFE44224.1 - 0.043 13.0 0.0 0.089 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFE44224.1 - 0.048 13.2 0.0 0.094 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 EFE44224.1 - 0.062 13.2 0.0 0.24 11.3 0.0 1.9 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea CPT PF07931.12 EFE44224.1 - 0.063 13.1 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_6 PF12774.7 EFE44224.1 - 0.067 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 EFE44224.1 - 0.073 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 EFE44224.1 - 0.1 11.8 0.0 0.36 10.0 0.0 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain ATPase PF06745.13 EFE44224.1 - 0.13 11.6 0.0 0.55 9.5 0.0 1.9 1 1 1 2 2 2 0 KaiC EOS1 PF12326.8 EFE44224.1 - 0.15 12.0 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 N-glycosylation protein Viral_helicase1 PF01443.18 EFE44224.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_21 PF13304.6 EFE44224.1 - 0.29 10.9 1.1 21 4.8 0.1 2.8 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Cys_Met_Meta_PP PF01053.20 EFE44225.1 - 8.7e-137 455.7 0.0 1.3e-136 455.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EFE44225.1 - 0.00031 20.2 0.0 0.00084 18.7 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EFE44225.1 - 0.012 14.9 0.0 0.049 12.9 0.0 1.7 2 0 0 2 2 2 0 Beta-eliminating lyase MFS_1 PF07690.16 EFE44226.1 - 7.9e-37 127.0 31.3 2.2e-24 86.1 15.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MTP18 PF10558.9 EFE44228.1 - 1.3e-81 272.6 0.0 2.7e-81 271.6 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) ATP19 PF11022.8 EFE44229.1 - 1e-12 48.2 0.1 1.2e-12 48.0 0.1 1.1 1 0 0 1 1 1 1 ATP synthase subunit K AAT PF03417.16 EFE44230.1 - 2.5e-29 102.6 0.0 3.2e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase ACPS PF01648.20 EFE44231.1 - 9.7e-15 54.7 0.0 1.9e-14 53.7 0.0 1.5 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 EFE44231.1 - 0.071 13.2 1.7 4.8 7.4 0.1 2.7 3 0 0 3 3 3 0 4'-phosphopantetheinyl transferase N-terminal domain APH PF01636.23 EFE44232.1 - 0.0019 18.2 0.0 0.0022 18.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family APH PF01636.23 EFE44233.1 - 6.3e-07 29.6 0.0 1.1e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE44233.1 - 0.017 14.0 0.1 0.048 12.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EFE44233.1 - 0.073 12.7 0.0 0.13 11.8 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase EcKinase PF02958.20 EFE44233.1 - 0.078 12.3 0.1 0.44 9.8 0.0 2.0 2 0 0 2 2 2 0 Ecdysteroid kinase Kdo PF06293.14 EFE44234.1 - 8.4e-07 28.5 0.0 0.00011 21.6 0.0 2.1 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFE44234.1 - 1.7e-05 24.9 0.1 0.13 12.2 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EFE44234.1 - 0.00066 19.3 0.0 0.001 18.7 0.0 1.2 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.11 EFE44234.1 - 0.012 15.3 0.1 0.016 14.8 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Choline_kinase PF01633.20 EFE44234.1 - 0.086 12.4 0.0 5.7 6.5 0.0 2.2 1 1 1 2 2 2 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 EFE44234.1 - 0.097 11.4 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Pkinase PF00069.25 EFE44234.1 - 0.1 12.0 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein kinase domain F-box_4 PF15966.5 EFE44235.1 - 0.023 14.5 0.1 0.051 13.5 0.1 1.5 1 0 0 1 1 1 0 F-box F-box PF00646.33 EFE44235.1 - 0.052 13.4 0.5 0.052 13.4 0.5 2.3 2 0 0 2 2 2 0 F-box domain PHP PF02811.19 EFE44236.1 - 7.2e-12 45.9 0.0 1e-11 45.4 0.0 1.2 1 0 0 1 1 1 1 PHP domain IFP_35_N PF07334.13 EFE44236.1 - 0.13 12.4 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus K_channel_TID PF07941.11 EFE44237.1 - 0.011 16.2 0.5 0.016 15.7 0.5 1.3 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain AA_permease PF00324.21 EFE44238.1 - 9.5e-129 430.1 45.9 1.2e-128 429.7 45.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE44238.1 - 5.9e-23 81.4 52.7 1.1e-22 80.5 52.7 1.3 1 1 0 1 1 1 1 Amino acid permease HHV-1_VABD PF16852.5 EFE44239.1 - 0.087 12.8 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Herpes viral adaptor-to-host cellular mRNA binding domain FKBP_C PF00254.28 EFE44240.1 - 5.9e-11 42.5 0.0 1.7e-10 41.1 0.0 1.7 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase F-box PF00646.33 EFE44241.1 - 0.0019 18.1 0.3 0.0052 16.6 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EFE44241.1 - 0.13 12.2 0.2 0.3 11.0 0.2 1.7 1 0 0 1 1 1 0 F-box CLTH PF10607.9 EFE44241.1 - 0.18 11.7 0.5 0.31 10.9 0.5 1.3 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain DUF3446 PF11928.8 EFE44241.1 - 0.99 9.8 9.4 0.1 12.9 1.6 2.7 3 0 0 3 3 3 0 Early growth response N-terminal domain Nop53 PF07767.11 EFE44243.1 - 0.056 12.8 15.8 0.065 12.6 15.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) BORG_CEP PF14957.6 EFE44243.1 - 0.18 13.0 2.2 0.19 12.9 2.2 1.0 1 0 0 1 1 1 0 Cdc42 effector Dicty_REP PF05086.12 EFE44243.1 - 0.33 8.9 4.0 0.36 8.8 4.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein YqfQ PF14181.6 EFE44243.1 - 0.57 10.4 7.6 0.71 10.0 7.6 1.1 1 0 0 1 1 1 0 YqfQ-like protein RR_TM4-6 PF06459.12 EFE44243.1 - 3.4 7.4 9.3 4.3 7.1 9.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SR-25 PF10500.9 EFE44245.1 - 0.041 13.5 14.9 0.052 13.1 14.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4820 PF16091.5 EFE44245.1 - 0.064 12.6 4.0 0.072 12.4 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Med19 PF10278.9 EFE44245.1 - 0.081 12.9 13.3 0.098 12.6 13.3 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Coilin_N PF15862.5 EFE44245.1 - 0.082 12.7 8.9 0.1 12.4 8.9 1.2 1 0 0 1 1 1 0 Coilin N-terminus GEN1_C PF18380.1 EFE44245.1 - 0.096 13.6 2.5 0.13 13.2 2.5 1.2 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain AP3D1 PF06375.11 EFE44245.1 - 0.29 11.3 15.6 0.38 11.0 15.6 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Connexin PF00029.19 EFE44245.1 - 0.31 10.8 3.9 0.38 10.5 3.9 1.1 1 0 0 1 1 1 0 Connexin RNA_polI_A34 PF08208.11 EFE44245.1 - 0.71 9.9 16.2 0.9 9.6 16.2 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 FAM176 PF14851.6 EFE44245.1 - 1 9.0 3.8 1.6 8.4 3.8 1.3 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 EFE44245.1 - 1.5 7.5 3.0 1.8 7.3 3.0 1.1 1 0 0 1 1 1 0 Presenilin DUF3464 PF11947.8 EFE44245.1 - 1.9 8.2 7.8 2.3 8.0 7.8 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peptidase_S49_N PF08496.10 EFE44245.1 - 4.2 7.4 11.1 5.1 7.1 11.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Folate_carrier PF01770.18 EFE44245.1 - 8 5.1 4.9 9.5 4.8 4.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier zf-UBR PF02207.20 EFE44248.1 - 5.4e-16 58.5 19.7 5.4e-16 58.5 19.7 2.2 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EFE44248.1 - 6.1e-05 22.7 0.0 0.00019 21.2 0.0 1.8 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_2 PF13639.6 EFE44248.1 - 0.015 15.6 1.0 0.015 15.6 1.0 4.1 3 0 0 3 3 3 0 Ring finger domain ELL PF10390.9 EFE44248.1 - 0.063 12.8 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL TPR_7 PF13176.6 EFE44249.1 - 1.3e-10 40.5 0.4 0.0059 16.6 0.1 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFE44249.1 - 6.6e-10 38.3 0.6 0.085 13.0 0.1 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFE44249.1 - 5.1e-09 36.5 0.0 0.0093 16.5 0.0 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFE44249.1 - 1.1e-07 32.1 0.0 1.7 9.7 0.0 5.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFE44249.1 - 4e-07 30.2 3.4 0.02 15.2 0.0 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFE44249.1 - 4.9e-07 29.5 3.4 1.6 9.1 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EFE44249.1 - 4.6e-06 26.2 0.1 1.1e-05 25.0 0.1 1.6 1 1 0 1 1 1 1 MalT-like TPR region TPR_1 PF00515.28 EFE44249.1 - 0.0024 17.6 0.1 0.71 9.8 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_22 PF13401.6 EFE44249.1 - 0.0046 17.2 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain TPR_10 PF13374.6 EFE44249.1 - 0.0094 15.8 1.0 0.29 11.1 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat AAA_16 PF13191.6 EFE44249.1 - 0.011 16.2 0.0 0.031 14.7 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EFE44249.1 - 0.038 13.2 0.0 0.083 12.1 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain PPR PF01535.20 EFE44249.1 - 0.12 12.7 2.4 48 4.5 0.0 4.3 5 0 0 5 5 4 0 PPR repeat Mur_ligase_M PF08245.12 EFE44250.1 - 0.00011 22.3 0.4 0.00071 19.6 0.1 2.5 3 1 0 3 3 3 1 Mur ligase middle domain CENP-S PF15630.6 EFE44251.1 - 3.1e-10 40.3 0.0 3.6e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein PGA2 PF07543.12 EFE44252.1 - 6.3e-44 149.3 0.9 7.3e-44 149.1 0.9 1.0 1 0 0 1 1 1 1 Protein trafficking PGA2 CCD PF07860.11 EFE44252.1 - 0.02 14.9 0.3 0.11 12.6 0.0 2.1 1 1 1 2 2 2 0 WisP family C-Terminal Region Remorin_C PF03763.13 EFE44252.1 - 0.081 12.8 3.9 0.27 11.1 0.3 2.1 2 0 0 2 2 2 0 Remorin, C-terminal region MARVEL PF01284.23 EFE44253.1 - 0.00047 20.2 12.4 0.00087 19.3 12.1 1.6 1 1 1 2 2 2 1 Membrane-associating domain Phage_r1t_holin PF16945.5 EFE44253.1 - 0.11 12.7 0.1 0.26 11.5 0.1 1.6 1 0 0 1 1 1 0 Putative lactococcus lactis phage r1t holin Glyco_hydro_61 PF03443.14 EFE44254.1 - 0.0044 17.0 0.4 0.025 14.5 0.0 2.2 2 1 1 3 3 3 1 Glycosyl hydrolase family 61 Pox_A14 PF05767.12 EFE44254.1 - 0.064 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 FTR_C PF02741.15 EFE44254.1 - 0.095 12.7 0.2 0.17 11.9 0.2 1.3 1 0 0 1 1 1 0 FTR, proximal lobe DUF2235 PF09994.9 EFE44255.1 - 3.4e-87 292.4 0.0 4.8e-87 291.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) An_peroxidase PF03098.15 EFE44256.1 - 2.5e-41 141.9 0.0 5e-27 94.7 0.0 3.2 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 EFE44257.1 - 7.4e-07 28.3 0.0 3.5e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 Cytochrome P450 Hexapep PF00132.24 EFE44258.1 - 5.9e-06 25.8 11.2 8.8e-05 22.1 2.8 4.5 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFE44258.1 - 0.008 15.9 0.5 0.008 15.9 0.5 2.7 2 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase Arrestin_C PF02752.22 EFE44259.1 - 2.9e-18 66.6 0.0 5.2e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFE44259.1 - 1.2e-06 28.7 0.0 2.4e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Apolipoprotein PF01442.18 EFE44260.1 - 0.042 13.7 2.5 0.035 14.0 1.0 1.6 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Glyoxalase PF00903.25 EFE44262.1 - 2.6e-34 118.2 0.0 1.9e-16 60.4 0.0 2.1 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFE44262.1 - 1.8e-18 66.8 0.0 2.8e-06 27.6 0.0 3.8 1 1 3 4 4 4 4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EFE44262.1 - 5.8e-07 30.3 0.0 0.0021 18.8 0.0 3.1 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EFE44262.1 - 2.1e-06 27.9 0.0 0.012 15.7 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EFE44262.1 - 0.044 13.7 0.2 4.5 7.2 0.0 3.3 4 1 1 5 5 5 0 Glyoxalase-like domain CppA_N PF14506.6 EFE44262.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 CppA N-terminal MoaF PF10703.9 EFE44262.1 - 0.15 12.0 0.0 5.2 7.1 0.0 2.4 2 0 0 2 2 2 0 MoaF N-terminal domain HTH_54 PF18607.1 EFE44262.1 - 0.18 11.9 0.0 4 7.6 0.0 2.7 3 0 0 3 3 3 0 ParA helix turn helix domain Kin17_mid PF10357.9 EFE44263.1 - 8e-48 161.5 1.6 1.6e-47 160.5 1.6 1.5 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 EFE44263.1 - 2.3e-05 24.6 0.9 5.5e-05 23.4 0.9 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFE44263.1 - 0.00046 20.4 0.3 0.00046 20.4 0.3 2.0 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EFE44263.1 - 0.0081 16.5 2.9 0.013 15.8 0.4 2.2 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) Hydin_ADK PF17213.3 EFE44263.1 - 2.5 8.3 5.2 1.1 9.5 2.9 1.5 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Ig_GlcNase PF18368.1 EFE44264.1 - 2.1e-36 124.2 0.2 3.1e-35 120.5 0.1 2.7 2 0 0 2 2 2 1 Exo-beta-D-glucosaminidase Ig-fold domain Glyco_hydro_2 PF00703.21 EFE44264.1 - 3e-10 40.7 0.3 3.1e-09 37.5 0.0 2.7 2 1 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EFE44264.1 - 3.6e-07 30.3 0.1 9.1e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Mannosidase_ig PF17786.1 EFE44264.1 - 6.8e-07 29.8 0.2 3.6e-05 24.3 0.0 2.6 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain DNA_circ_N PF07157.12 EFE44264.1 - 0.0094 16.3 0.0 3.1 8.2 0.0 3.1 2 0 0 2 2 2 1 DNA circularisation protein N-terminus Ig_mannosidase PF17753.1 EFE44264.1 - 0.023 14.4 0.1 0.3 10.9 0.0 2.6 2 0 0 2 2 2 0 Ig-fold domain DUF3344 PF11824.8 EFE44264.1 - 0.056 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3344) Glyco_hydro_2_C PF02836.17 EFE44264.1 - 0.085 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain GAPES2 PF17156.4 EFE44264.1 - 0.14 12.0 0.1 0.42 10.3 0.0 1.8 2 0 0 2 2 2 0 Gammaproteobacterial periplasmic sensor domain Ank_2 PF12796.7 EFE44265.1 - 1.5e-68 227.3 14.2 5.8e-15 55.6 0.3 6.5 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE44265.1 - 2.4e-65 216.1 12.5 1.3e-11 44.8 0.2 8.5 4 3 4 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE44265.1 - 1.3e-51 166.5 11.6 5.6e-05 23.2 0.0 12.0 12 0 0 12 12 12 9 Ankyrin repeat Ank PF00023.30 EFE44265.1 - 3.5e-47 156.9 15.7 7e-06 26.3 0.0 11.9 12 0 0 12 12 12 11 Ankyrin repeat Ank_5 PF13857.6 EFE44265.1 - 3.6e-45 151.4 14.6 1.5e-07 31.5 0.0 9.8 5 2 5 10 10 10 9 Ankyrin repeats (many copies) La_HTH_kDCL PF18177.1 EFE44265.1 - 0.094 13.0 1.4 11 6.4 0.0 3.5 2 1 1 3 3 3 0 La HTH in kinetoplastid DICER domain Fe-ADH PF00465.19 EFE44266.1 - 3.9e-103 345.1 0.0 5e-103 344.7 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EFE44266.1 - 3.4e-16 59.7 0.0 5.6e-12 45.9 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 EFE44266.1 - 0.0091 15.7 0.1 0.015 15.0 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein 2-Hacid_dh_C PF02826.19 EFE44267.1 - 8.3e-54 181.6 0.0 1.3e-53 181.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFE44267.1 - 5.4e-36 123.2 0.1 8.7e-36 122.5 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AlaDh_PNT_C PF01262.21 EFE44267.1 - 0.0012 18.2 2.7 0.0052 16.1 2.7 1.9 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain XdhC_C PF13478.6 EFE44267.1 - 0.0028 18.1 0.0 0.0083 16.6 0.0 1.8 1 0 0 1 1 1 1 XdhC Rossmann domain ACT PF01842.25 EFE44267.1 - 0.037 13.8 0.3 0.31 10.9 0.0 2.6 3 0 0 3 3 3 0 ACT domain F420_oxidored PF03807.17 EFE44267.1 - 0.045 14.3 0.7 9.6 6.9 0.1 2.8 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFE44267.1 - 0.096 12.9 0.7 0.28 11.3 0.1 2.0 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase p450 PF00067.22 EFE44269.1 - 1.3e-59 202.1 0.0 3.5e-43 148.0 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Glyco_hydro_20 PF00728.22 EFE44270.1 - 3.3e-76 257.0 0.0 4.7e-76 256.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFE44270.1 - 3e-33 115.4 0.2 1.3e-32 113.3 0.2 2.1 3 0 0 3 3 3 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFE44270.1 - 0.00016 22.5 0.0 0.0027 18.5 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 zf-CCCH_2 PF14608.6 EFE44271.1 - 1.9e-11 44.0 54.0 1.5e-06 28.5 10.1 5.5 5 0 0 5 5 5 4 RNA-binding, Nab2-type zinc finger Nab2 PF11517.8 EFE44271.1 - 0.017 15.4 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Amino_oxidase PF01593.24 EFE44272.1 - 1.9e-19 70.3 0.0 2.2e-19 70.1 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Mago-bind PF09282.10 EFE44273.1 - 3.8e-14 52.3 2.6 7.9e-14 51.2 2.6 1.6 1 0 0 1 1 1 1 Mago binding GTP1_OBG PF01018.22 EFE44274.1 - 4.8e-37 126.9 2.3 4.1e-27 94.7 3.3 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 EFE44274.1 - 8.8e-23 80.6 0.0 1.6e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFE44274.1 - 7.2e-08 32.1 0.0 1.5e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 EFE44274.1 - 0.02 13.9 0.0 0.51 9.3 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EFE44274.1 - 0.098 13.2 2.0 0.15 12.6 0.1 2.2 2 0 0 2 2 2 0 ABC transporter UQ_con PF00179.26 EFE44275.1 - 3.6e-07 29.9 0.5 7.6e-07 28.9 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFE44275.1 - 0.17 12.2 0.2 0.3 11.4 0.2 1.4 1 0 0 1 1 1 0 RWD domain FH2 PF02181.23 EFE44276.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain 2OG-FeII_Oxy_2 PF13532.6 EFE44277.1 - 1.8e-21 77.2 0.0 3.2e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CUE PF02845.16 EFE44277.1 - 6e-07 29.0 0.0 1.1e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain POTRA_3 PF17287.2 EFE44277.1 - 0.048 13.1 0.0 3.7 7.1 0.0 2.4 2 0 0 2 2 2 0 POTRA domain DUF4294 PF14127.6 EFE44277.1 - 0.078 12.9 0.5 0.12 12.2 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) Cupin_8 PF13621.6 EFE44278.1 - 2.3e-32 112.7 0.0 5e-32 111.6 0.0 1.5 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EFE44278.1 - 5e-06 26.2 0.0 0.0019 17.7 0.0 2.5 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.22 EFE44278.1 - 0.11 13.0 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 JmjC domain, hydroxylase Homeobox_KN PF05920.11 EFE44279.1 - 6.7e-16 57.9 0.6 1.9e-15 56.5 0.1 2.1 2 0 0 2 2 2 1 Homeobox KN domain HTH_Tnp_Tc5 PF03221.16 EFE44279.1 - 0.00023 21.1 0.0 0.0012 18.8 0.0 2.2 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Homeodomain PF00046.29 EFE44279.1 - 0.00024 20.9 0.0 0.00069 19.4 0.0 1.9 1 0 0 1 1 1 1 Homeodomain zf-C2H2_4 PF13894.6 EFE44279.1 - 0.00075 20.1 1.5 0.00075 20.1 1.5 5.3 6 0 0 6 6 6 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE44279.1 - 0.0012 19.2 22.3 0.072 13.6 1.6 5.2 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-Sec23_Sec24 PF04810.15 EFE44279.1 - 0.2 11.8 5.7 3.5 7.8 0.1 3.4 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-H2C2_2 PF13465.6 EFE44279.1 - 0.43 11.1 9.0 3.3 8.3 0.1 3.9 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_3rep PF18868.1 EFE44279.1 - 1.3 9.8 6.0 1 10.0 0.3 2.9 2 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats Fungal_trans PF04082.18 EFE44280.1 - 1.6e-26 92.9 0.0 7e-26 90.8 0.0 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF4834 PF16118.5 EFE44280.1 - 9 7.3 8.6 5.6 8.0 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DnaJ PF00226.31 EFE44281.1 - 3.4e-22 78.3 1.1 6.7e-22 77.4 1.1 1.5 1 0 0 1 1 1 1 DnaJ domain Adenylsucc_synt PF00709.21 EFE44282.1 - 2.3e-164 547.3 0.1 2.9e-163 543.7 0.1 1.9 1 1 0 1 1 1 1 Adenylosuccinate synthetase KHA PF11834.8 EFE44282.1 - 0.11 12.6 0.4 0.4 10.8 0.0 2.2 3 0 0 3 3 3 0 KHA, dimerisation domain of potassium ion channel Ank_2 PF12796.7 EFE44283.1 - 4.2e-30 104.2 21.8 5.9e-06 26.8 0.0 12.5 7 3 5 13 13 13 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE44283.1 - 1.9e-23 82.5 16.6 0.053 14.1 0.0 13.8 13 3 1 14 14 14 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFE44283.1 - 1.2e-14 54.1 0.4 0.53 10.7 0.0 10.4 10 1 1 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE44283.1 - 1.9e-13 49.3 15.0 9.9 7.1 0.0 15.8 20 0 0 20 20 20 2 Ankyrin repeat Ank PF00023.30 EFE44283.1 - 1.7e-09 37.7 31.0 3.9 8.1 0.0 15.2 17 2 0 17 17 17 2 Ankyrin repeat Polysacc_deac_1 PF01522.21 EFE44283.1 - 0.11 12.4 0.1 1.4 8.8 0.1 2.6 3 0 0 3 3 3 0 Polysaccharide deacetylase NigD_C PF17415.2 EFE44283.1 - 0.16 12.0 0.0 0.68 10.0 0.0 2.0 1 0 0 1 1 1 0 NigD-like C-terminal beta sandwich domain DEAD PF00270.29 EFE44284.1 - 3.7e-43 147.3 0.0 5.5e-43 146.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE44284.1 - 9.2e-19 67.8 0.2 4.6e-18 65.6 0.1 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE44284.1 - 8.4e-05 22.6 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Aldolase_II PF00596.21 EFE44285.1 - 4.7e-45 153.8 0.1 5.9e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain PLAC8 PF04749.17 EFE44286.1 - 9.3e-10 39.4 6.7 1.9e-09 38.4 6.7 1.6 1 1 0 1 1 1 1 PLAC8 family RNase_H PF00075.24 EFE44287.1 - 4.2e-22 78.9 0.3 5.6e-22 78.5 0.3 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EFE44287.1 - 5.5e-07 29.4 3.6 0.0001 22.1 3.6 2.6 1 1 0 1 1 1 1 Reverse transcriptase-like RNase_H PF00075.24 EFE44288.1 - 1.1e-22 80.8 0.0 1.6e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EFE44288.1 - 9.1e-08 32.0 0.1 3.9e-06 26.7 0.1 2.1 1 1 0 1 1 1 1 Reverse transcriptase-like TPT PF03151.16 EFE44290.1 - 8.7e-24 84.4 24.5 1.2e-23 84.0 24.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EFE44290.1 - 0.00037 19.8 23.9 0.00056 19.2 23.9 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EFE44290.1 - 0.033 14.4 32.5 0.4 10.9 9.5 2.9 3 0 0 3 3 3 0 EamA-like transporter family TFIIB PF00382.19 EFE44292.1 - 1.2e-30 105.4 0.4 4.1e-17 62.0 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EFE44292.1 - 5.1e-25 87.7 1.7 1.1e-24 86.7 0.0 2.6 3 0 0 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EFE44292.1 - 0.00012 21.5 2.7 0.00028 20.3 2.7 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 EFE44292.1 - 0.012 15.4 0.1 1.9 8.3 0.0 2.3 2 0 0 2 2 2 0 Cyclin, N-terminal domain zf-RRN7 PF11781.8 EFE44292.1 - 0.39 10.4 1.1 0.7 9.6 0.2 1.9 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 HMA PF00403.26 EFE44293.1 - 3.9e-38 129.7 3.1 7.3e-10 39.1 0.1 4.6 4 0 0 4 4 4 4 Heavy-metal-associated domain E1-E2_ATPase PF00122.20 EFE44293.1 - 9.6e-37 126.2 0.9 1.6e-35 122.3 0.9 2.5 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFE44293.1 - 1.7e-33 116.7 0.2 3.2e-33 115.8 0.2 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFE44293.1 - 8.1e-05 22.5 2.1 0.00086 19.1 0.6 2.3 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFE44293.1 - 0.017 15.6 0.0 0.038 14.4 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase ERCC4 PF02732.15 EFE44294.1 - 3.6e-26 92.2 0.0 6.4e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 EFE44294.1 - 0.0046 17.3 0.1 0.5 10.8 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix domain Ish1 PF10281.9 EFE44294.1 - 0.11 12.8 0.1 3.1 8.2 0.0 3.0 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein Fungal_trans PF04082.18 EFE44295.1 - 5.9e-05 22.2 0.1 0.00016 20.8 0.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain PRP3 PF08572.10 EFE44296.1 - 3.4e-74 249.4 2.5 6.2e-74 248.5 2.5 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EFE44296.1 - 3e-48 163.6 0.6 3e-48 163.6 0.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) PRIMA1 PF16101.5 EFE44296.1 - 0.71 9.9 6.0 5.7 7.0 0.1 2.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 EFE44296.1 - 1.9 7.9 12.4 0.67 9.4 1.9 2.9 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal RNA_pol_Rpb1_5 PF04998.17 EFE44297.1 - 3.5e-87 292.2 0.0 6e-87 291.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFE44297.1 - 6.7e-67 224.9 0.1 1.5e-66 223.7 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EFE44297.1 - 1.6e-34 119.1 0.0 6.1e-33 114.0 0.0 2.8 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EFE44297.1 - 1.9e-17 63.2 0.0 7.5e-17 61.2 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.12 EFE44297.1 - 7.4e-15 55.1 1.6 2.8e-13 49.9 1.5 3.1 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 CDC27 PF09507.10 EFE44297.1 - 1.3 8.4 11.4 4.5 6.6 11.4 1.9 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DEAD_2 PF06733.15 EFE44298.1 - 4.9e-53 179.4 0.2 1.1e-52 178.2 0.2 1.6 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 EFE44298.1 - 4.1e-48 163.6 1.9 6.9e-43 146.5 0.6 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EFE44298.1 - 4.8e-44 150.5 0.0 1.4e-43 149.0 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 EFE44298.1 - 0.00023 21.2 0.0 0.033 14.2 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EFE44298.1 - 0.0097 14.7 0.1 0.2 10.3 0.1 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain LCM PF04072.14 EFE44299.1 - 6.4e-23 81.7 0.0 1.4e-22 80.6 0.0 1.6 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase C1_1 PF00130.22 EFE44299.1 - 0.028 14.3 3.0 0.057 13.3 3.0 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.6 EFE44299.1 - 0.035 14.5 3.9 0.087 13.2 3.9 1.7 1 0 0 1 1 1 0 Ring finger domain DUF2913 PF11140.8 EFE44299.1 - 0.15 11.8 0.0 1.8 8.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2913) FANCL_C PF11793.8 EFE44299.1 - 0.38 11.0 2.7 0.78 10.0 2.7 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain SUN PF03856.13 EFE44300.1 - 1.1e-78 264.0 11.7 1.6e-78 263.5 11.7 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Apt1 PF10351.9 EFE44300.1 - 4.1 6.2 13.6 5.3 5.8 13.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 EFE44300.1 - 8.8 5.4 21.8 12 4.9 21.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein zf-CCCH_4 PF18044.1 EFE44301.1 - 7.7e-05 22.4 5.5 0.0023 17.7 2.0 2.2 2 0 0 2 2 2 2 CCCH-type zinc finger Sec3_C PF09763.9 EFE44301.1 - 0.088 11.2 0.0 0.088 11.2 0.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 zf-CCCH PF00642.24 EFE44301.1 - 0.17 11.9 7.2 1.3 9.1 3.2 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EFE44301.1 - 0.46 11.0 8.5 1 9.9 3.8 2.3 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Ist1 PF03398.14 EFE44302.1 - 2.8e-27 95.7 0.3 4.8e-15 55.9 1.1 2.2 2 0 0 2 2 2 2 Regulator of Vps4 activity in the MVB pathway Peptidase_S28 PF05577.12 EFE44305.1 - 3.9e-56 190.7 0.6 6.5e-56 190.0 0.6 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase S28 DAHP_synth_2 PF01474.16 EFE44306.1 - 6.9e-140 466.4 0.0 2.1e-81 273.7 0.0 2.0 1 1 0 2 2 2 2 Class-II DAHP synthetase family AMP-binding PF00501.28 EFE44308.1 - 2.1e-62 211.1 0.0 2.6e-62 210.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE44308.1 - 1.6e-05 25.8 0.1 5.1e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Orbi_NS1 PF01718.16 EFE44309.1 - 0.12 10.8 0.0 0.16 10.4 0.0 1.1 1 0 0 1 1 1 0 Orbivirus non-structural protein NS1, or hydrophobic tubular protein TP_methylase PF00590.20 EFE44310.1 - 4.4e-23 82.3 0.2 7.1e-23 81.7 0.2 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TFIID-18kDa PF02269.16 EFE44311.1 - 4.5e-25 87.5 0.1 5.6e-24 84.0 0.1 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Aminotran_1_2 PF00155.21 EFE44312.1 - 1.1e-62 212.3 0.0 1.4e-62 212.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFE44312.1 - 0.061 11.8 0.1 0.12 10.9 0.0 1.5 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Tam41_Mmp37 PF09139.11 EFE44314.1 - 9.3e-132 439.3 0.0 1.2e-131 439.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial BIR PF00653.21 EFE44315.1 - 1.1e-43 147.8 8.9 4.3e-21 75.3 0.2 2.5 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C2H2_jaz PF12171.8 EFE44316.1 - 2e-08 34.3 0.4 4e-08 33.4 0.4 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFE44316.1 - 9.3e-06 25.9 0.5 9.3e-06 25.9 0.5 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EFE44316.1 - 0.0008 19.7 0.4 0.0016 18.8 0.4 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EFE44316.1 - 0.12 12.7 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) F-box-like PF12937.7 EFE44317.1 - 0.0021 17.9 0.0 0.0047 16.8 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFE44317.1 - 0.0036 17.1 0.0 0.0099 15.7 0.0 1.8 1 0 0 1 1 1 1 F-box domain AMP-binding PF00501.28 EFE44318.1 - 2.3e-28 99.0 0.0 3.1e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EFE44318.1 - 0.17 11.8 0.1 0.39 10.7 0.1 1.7 1 1 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EFE44319.1 - 0.00018 22.4 0.0 0.00031 21.7 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Legionella_OMP PF05150.12 EFE44319.1 - 0.048 12.6 0.0 0.062 12.2 0.0 1.1 1 0 0 1 1 1 0 Legionella pneumophila major outer membrane protein precursor Ribosomal_L7Ae PF01248.26 EFE44321.1 - 3.7e-15 55.4 0.0 4.8e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Formyl_trans_N PF00551.19 EFE44322.1 - 1.3e-38 132.6 0.0 1.5e-38 132.4 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase SPA PF08616.10 EFE44323.1 - 5e-37 126.3 0.0 8.1e-37 125.7 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 EFE44323.1 - 4e-33 114.7 0.3 7.7e-33 113.8 0.3 1.4 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 EFE44323.1 - 1.4e-07 30.5 0.0 0.047 12.4 0.0 3.6 2 1 1 3 3 3 3 Transport protein Avl9 EF-hand_6 PF13405.6 EFE44324.1 - 1.5e-14 52.6 0.9 7.9e-06 25.4 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFE44324.1 - 6.3e-13 47.3 1.1 2.5e-05 23.5 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFE44324.1 - 1.1e-10 41.8 0.1 0.00067 20.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFE44324.1 - 8.5e-09 34.5 3.0 0.0017 17.8 0.4 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFE44324.1 - 1.1e-06 28.4 0.6 0.056 13.3 0.1 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 EFE44324.1 - 0.0003 21.0 0.0 0.87 10.0 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain RabGAP-TBC PF00566.18 EFE44325.1 - 3.3e-32 111.9 0.0 2.3e-31 109.2 0.0 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain SET PF00856.28 EFE44328.1 - 5.2e-09 36.7 0.0 1.3e-07 32.2 0.0 2.7 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 EFE44328.1 - 0.033 14.3 5.7 0.098 12.8 5.7 1.9 1 0 0 1 1 1 0 MYND finger WD40 PF00400.32 EFE44329.1 - 2.7e-22 78.6 15.0 3.2e-06 27.7 0.3 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE44329.1 - 0.00023 21.4 0.0 0.016 15.5 0.0 3.4 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain FAM76 PF16046.5 EFE44330.1 - 0.22 10.8 4.2 0.42 9.9 4.2 1.3 1 0 0 1 1 1 0 FAM76 protein Glucosamine_iso PF01182.20 EFE44331.1 - 2.6e-68 230.3 0.0 2.9e-68 230.1 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase F-box PF00646.33 EFE44333.1 - 0.00039 20.2 0.0 0.0013 18.5 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFE44333.1 - 0.0045 16.8 0.0 0.012 15.5 0.0 1.8 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EFE44333.1 - 0.14 12.3 0.1 3.7 7.9 0.0 2.9 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.7 EFE44333.1 - 0.43 11.1 7.3 43 4.7 0.1 5.2 5 2 2 7 7 7 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFE44333.1 - 1.3 8.8 5.7 2.2 8.1 0.0 4.0 6 0 0 6 6 6 0 Leucine rich repeat IDO PF01231.18 EFE44334.1 - 2.1e-29 102.6 0.0 2.6e-28 99.0 0.0 2.2 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase Glyco_hydro_16 PF00722.21 EFE44335.1 - 1.5e-05 24.5 0.2 2.5e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TPR_2 PF07719.17 EFE44336.1 - 4.5e-11 42.0 6.6 0.0061 16.6 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFE44336.1 - 1.8e-10 40.1 2.4 0.0059 16.4 0.0 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFE44336.1 - 6.9e-10 39.1 1.7 0.00016 21.9 0.1 4.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFE44336.1 - 8.7e-09 34.8 1.3 0.43 10.7 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFE44336.1 - 2.5e-07 30.4 1.4 0.17 12.2 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFE44336.1 - 2.8e-05 24.5 0.0 0.076 13.5 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFE44336.1 - 0.0023 18.5 8.7 0.85 10.4 0.1 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFE44336.1 - 0.0034 17.2 3.1 7.5 6.6 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFE44336.1 - 0.0042 17.8 0.7 64 4.8 0.0 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFE44336.1 - 0.066 12.9 0.4 14 5.5 0.0 3.5 2 1 1 3 3 3 0 TPR repeat TPR_16 PF13432.6 EFE44336.1 - 0.12 13.0 0.0 9.4 7.0 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFE44336.1 - 7.2 6.9 9.2 11 6.3 0.1 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Goodbye PF17109.5 EFE44337.1 - 8.4e-38 129.5 0.2 2.8e-37 127.8 0.0 2.0 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain AAA_16 PF13191.6 EFE44337.1 - 0.00025 21.5 0.0 0.0032 17.9 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EFE44337.1 - 0.013 15.5 0.0 0.041 13.8 0.0 2.0 2 1 0 2 2 2 0 NACHT domain DUF2075 PF09848.9 EFE44337.1 - 0.033 13.4 0.1 0.4 9.9 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) EspB PF05802.11 EFE44337.1 - 0.089 12.8 3.3 0.15 12.0 3.3 1.3 1 0 0 1 1 1 0 Enterobacterial EspB protein Msap1 PF17077.5 EFE44337.1 - 0.15 11.2 1.5 0.28 10.3 0.3 1.8 2 0 0 2 2 2 0 Mitotic spindle associated protein SHE1 CLTH PF10607.9 EFE44338.1 - 9.8e-27 93.7 0.0 1.9e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 EFE44338.1 - 1.9e-21 76.4 0.1 3.3e-21 75.6 0.1 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 EFE44338.1 - 0.0036 17.2 0.5 0.0092 15.9 0.1 2.0 2 0 0 2 2 2 1 LisH Serglycin PF04360.12 EFE44338.1 - 9.9 6.1 9.3 2.1 8.3 1.8 2.6 2 0 0 2 2 2 0 Serglycin INO80_Ies4 PF08193.11 EFE44339.1 - 1.6e-69 234.6 30.9 1.6e-69 234.6 30.9 1.9 1 1 1 2 2 2 1 INO80 complex subunit Ies4 DUF4820 PF16091.5 EFE44339.1 - 0.24 10.7 4.0 0.48 9.8 4.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PTPRCAP PF15713.5 EFE44339.1 - 0.29 11.4 16.5 0.25 11.6 10.0 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated SpoIIP PF07454.11 EFE44339.1 - 0.6 9.5 6.7 1 8.7 6.7 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FGF-BP1 PF06473.12 EFE44339.1 - 0.7 9.7 14.3 0.11 12.3 9.4 1.9 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) SAPS PF04499.15 EFE44339.1 - 0.71 8.6 7.3 0.041 12.7 1.9 1.6 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein CPSF100_C PF13299.6 EFE44339.1 - 2.7 8.2 11.6 0.64 10.2 6.3 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal MCM_bind PF09739.9 EFE44339.1 - 5.3 5.4 5.8 7.9 4.8 5.8 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DnaJ PF00226.31 EFE44340.1 - 2.9e-13 49.7 0.0 6.1e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain RPA43_OB PF17875.1 EFE44341.1 - 1e-40 139.2 0.0 1e-40 139.2 0.0 3.5 3 1 0 3 3 3 1 RPA43 OB domain in RNA Pol I FAP PF07174.11 EFE44342.1 - 8 5.8 21.2 2.4 7.5 17.3 1.9 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) MFS_1 PF07690.16 EFE44343.1 - 2.7e-21 75.9 56.6 1.9e-19 69.8 33.3 3.7 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFE44343.1 - 1.3e-09 37.0 7.4 4.1e-06 25.5 1.7 2.3 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sulfate_transp PF00916.20 EFE44344.1 - 1.9e-104 349.4 20.0 2.5e-104 349.0 20.0 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EFE44344.1 - 1.1e-06 28.2 0.0 2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 STAS domain DnaJ_C PF01556.18 EFE44346.1 - 1.1e-38 132.6 0.0 1.5e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFE44346.1 - 1e-24 86.4 2.5 1.7e-24 85.7 2.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFE44346.1 - 9e-15 54.8 18.6 1.6e-14 54.0 18.6 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 EFE44346.1 - 1.2 9.1 10.0 1.5 8.8 2.3 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA URO-D PF01208.17 EFE44347.1 - 3.8e-116 388.0 0.0 4.6e-116 387.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Nod1 PF17114.5 EFE44347.1 - 0.13 12.5 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 WD40 PF00400.32 EFE44348.1 - 0.0071 17.2 3.0 0.31 12.0 0.7 3.8 5 0 0 5 5 5 1 WD domain, G-beta repeat Pyocin_S PF06958.12 EFE44348.1 - 0.51 10.9 2.8 2 9.0 0.7 2.4 2 0 0 2 2 2 0 S-type Pyocin Ribosomal_L10 PF00466.20 EFE44349.1 - 4.7e-21 74.8 0.0 1.1e-20 73.6 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EFE44349.1 - 1.4e-20 73.1 0.1 2.6e-20 72.2 0.1 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EFE44349.1 - 7.3e-11 42.5 1.6 7.3e-11 42.5 1.6 1.9 2 0 0 2 2 2 1 60s Acidic ribosomal protein PDEase_I PF00233.19 EFE44351.1 - 1e-55 189.1 0.0 1.6e-55 188.5 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase RR_TM4-6 PF06459.12 EFE44352.1 - 2.5 7.8 7.1 3.3 7.4 7.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 EFE44352.1 - 6.4 4.8 6.2 7.1 4.6 6.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PCI PF01399.27 EFE44353.1 - 2.9e-12 47.0 0.6 1.4e-10 41.6 0.0 3.1 2 0 0 2 2 2 1 PCI domain BAH PF01426.18 EFE44353.1 - 0.0021 17.9 0.3 0.0071 16.2 0.3 2.0 1 1 0 1 1 1 1 BAH domain Pro_Al_protease PF02983.14 EFE44353.1 - 0.046 13.8 0.3 0.33 11.0 0.0 2.7 2 0 0 2 2 2 0 Alpha-lytic protease prodomain CENP-Q PF13094.6 EFE44355.1 - 0.058 13.6 1.0 0.5 10.6 0.2 2.4 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Phage_NinH PF06322.11 EFE44355.1 - 0.067 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Phage NinH protein Lectin_N PF03954.14 EFE44355.1 - 0.92 9.3 4.1 5.9 6.7 1.6 2.2 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Acetyltransf_1 PF00583.25 EFE44356.1 - 1e-07 32.2 0.0 1.5e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE44356.1 - 7.6e-05 22.6 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE44356.1 - 0.00035 20.9 0.0 0.00049 20.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE44356.1 - 0.034 14.2 0.0 0.049 13.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFE44356.1 - 0.083 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein MFS_1 PF07690.16 EFE44357.1 - 1.1e-21 77.2 52.6 3.8e-17 62.2 37.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 EFE44358.1 - 8e-19 68.0 0.0 1e-18 67.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44358.1 - 6.9e-17 61.6 0.0 8.6e-17 61.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE44358.1 - 3e-06 26.8 0.0 4.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EFE44358.1 - 0.0091 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFE44358.1 - 0.021 14.8 0.1 0.041 13.8 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_S10 PF00338.22 EFE44358.1 - 0.021 15.0 0.1 0.057 13.7 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein S10p/S20e NICE-3 PF07406.11 EFE44358.1 - 0.083 12.9 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 NICE-3 protein Choline_kinase PF01633.20 EFE44358.1 - 0.13 11.9 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RNA_pol_Rpb6 PF01192.22 EFE44359.1 - 0.00069 19.5 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 zf-C2H2 PF00096.26 EFE44360.1 - 3.7e-25 86.9 56.8 0.00079 19.8 0.7 11.6 11 1 1 12 12 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE44360.1 - 8.8e-16 57.3 57.3 0.016 16.0 0.7 10.9 11 0 0 11 11 11 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFE44360.1 - 1.1e-11 44.6 48.8 0.0034 17.7 0.2 10.8 12 0 0 12 12 11 6 Zinc-finger double domain FOXP-CC PF16159.5 EFE44360.1 - 2.8e-05 24.7 33.1 0.16 12.6 0.3 8.4 6 2 3 9 9 9 3 FOXP coiled-coil domain GAGA PF09237.11 EFE44360.1 - 0.00052 19.8 0.6 0.00052 19.8 0.6 2.4 2 0 0 2 2 2 1 GAGA factor zf-C2H2_jaz PF12171.8 EFE44360.1 - 0.00074 19.7 13.2 2.7 8.4 0.0 7.6 9 0 0 9 9 9 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EFE44360.1 - 0.013 15.2 20.5 1.6 8.6 2.7 5.8 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 EFE44360.1 - 0.017 15.4 19.7 0.12 12.7 1.5 4.3 2 2 1 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_3rep PF18868.1 EFE44360.1 - 0.023 15.4 16.1 3.1 8.5 1.1 5.1 4 2 1 5 5 5 0 Zinc finger C2H2-type, 3 repeats CHORD PF04968.12 EFE44360.1 - 0.21 12.4 15.6 3.5 8.4 1.0 4.8 3 1 1 4 4 4 0 CHORD DUF5472 PF17566.2 EFE44360.1 - 0.76 9.8 3.3 11 6.0 0.1 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5472) zf-C2H2_aberr PF17017.5 EFE44360.1 - 0.97 9.6 13.9 8.7 6.5 0.4 4.7 3 1 2 5 5 5 0 Aberrant zinc-finger zf-C2H2_9 PF16293.5 EFE44360.1 - 3.1 7.7 5.9 11 5.9 0.7 3.5 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) PH PF00169.29 EFE44362.1 - 2.4e-06 28.0 0.0 1.6e-05 25.4 0.0 2.3 2 0 0 2 2 2 1 PH domain DUF4230 PF14014.6 EFE44362.1 - 6.6 7.0 9.1 14 5.9 9.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) COPIIcoated_ERV PF07970.12 EFE44363.1 - 5.6e-80 268.3 0.0 8.9e-80 267.7 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EFE44363.1 - 1.4e-29 102.3 0.0 4.6e-29 100.6 0.0 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) TAP_C PF03943.13 EFE44364.1 - 3.7e-12 45.7 1.1 8.8e-12 44.5 1.1 1.6 1 0 0 1 1 1 1 TAP C-terminal domain LRR_9 PF14580.6 EFE44364.1 - 5.7e-07 29.2 0.0 9.4e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFE44364.1 - 3.8e-05 24.0 5.6 0.0012 19.1 0.3 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) NTF2 PF02136.20 EFE44364.1 - 0.00017 22.1 0.0 0.00055 20.5 0.0 1.9 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_8 PF13855.6 EFE44364.1 - 0.0041 16.9 0.3 0.011 15.5 0.3 1.8 1 0 0 1 1 1 1 Leucine rich repeat RRM_9 PF18444.1 EFE44364.1 - 0.038 13.8 0.0 0.25 11.2 0.0 2.4 1 1 0 1 1 1 0 RNA recognition motif Vps53_N PF04100.12 EFE44365.1 - 4.1e-107 358.4 9.1 8.1e-107 357.5 9.1 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal Vps54_N PF10475.9 EFE44365.1 - 3.9e-08 32.9 6.1 7.8e-08 31.9 6.1 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EFE44365.1 - 0.00027 20.8 0.8 0.00098 19.0 0.0 2.3 2 1 1 3 3 3 1 Protein of unknown function C-terminus (DUF2451) COG2 PF06148.11 EFE44365.1 - 0.0054 16.8 3.4 0.008 16.3 1.1 2.5 3 0 0 3 3 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Plk4_PB2 PF18409.1 EFE44365.1 - 0.19 12.4 7.0 2.4 8.9 0.7 4.3 2 1 2 4 4 4 0 Polo-like Kinase 4 Polo Box 2 FTCD_C PF04961.12 EFE44365.1 - 0.27 11.0 3.3 13 5.5 1.8 3.2 3 0 0 3 3 3 0 Formiminotransferase-cyclodeaminase TRPM_tetra PF16519.5 EFE44365.1 - 0.3 11.2 1.5 0.78 9.9 1.5 1.7 1 0 0 1 1 1 0 Tetramerisation domain of TRPM GIT1_C PF12205.8 EFE44365.1 - 0.75 9.9 8.9 0.87 9.7 1.5 2.9 1 1 1 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term Mod_r PF07200.13 EFE44365.1 - 0.96 9.5 10.8 1.4 9.0 7.3 3.1 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein EF-G-binding_N PF07299.11 EFE44365.1 - 1.8 9.1 9.3 0.29 11.7 2.4 3.3 4 0 0 4 4 4 0 Elongation factor G-binding protein, N-terminal Sigma70_ner PF04546.13 EFE44365.1 - 2.8 7.8 9.7 2.9 7.7 6.2 2.7 2 1 0 2 2 2 0 Sigma-70, non-essential region DUF3037 PF11236.8 EFE44365.1 - 3.5 8.1 4.8 1.4 9.3 0.2 2.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3037) Phage_GPO PF05929.11 EFE44365.1 - 7 6.2 9.2 5.2 6.6 5.9 2.2 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4332 PF14229.6 EFE44366.1 - 0.033 14.4 0.1 0.068 13.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) HHH_5 PF14520.6 EFE44366.1 - 0.046 14.3 0.0 0.15 12.7 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain DEAD PF00270.29 EFE44367.1 - 8.6e-16 58.2 0.1 2.5e-15 56.7 0.1 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFE44367.1 - 2.2e-06 27.8 0.0 4.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1524 PF07510.11 EFE44369.1 - 2.5e-09 37.1 0.0 3.2e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) HNH_4 PF13395.6 EFE44369.1 - 0.053 13.4 2.5 0.12 12.2 1.0 2.2 2 1 0 2 2 2 0 HNH endonuclease RrnaAD PF00398.20 EFE44370.1 - 0.0047 16.0 0.0 0.0074 15.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DUF4604 PF15377.6 EFE44371.1 - 4.7e-20 72.7 15.8 5.1e-20 72.6 15.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) DRY_EERY PF09750.9 EFE44371.1 - 1.8 8.9 8.8 8.4 6.7 8.8 1.9 1 1 0 1 1 1 0 Alternative splicing regulator Prp19 PF08606.11 EFE44372.1 - 4e-33 113.2 1.2 7.5e-33 112.3 1.2 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 EFE44372.1 - 1.3e-14 54.2 0.1 2.5e-07 30.9 0.0 4.8 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFE44372.1 - 7.3e-09 36.1 13.1 2.5e-05 24.9 0.0 6.1 7 0 0 7 7 7 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EFE44372.1 - 8.8e-09 34.9 0.2 3.2e-05 23.2 0.2 2.1 1 1 0 1 1 1 1 Coatomer WD associated region eIF2A PF08662.11 EFE44372.1 - 2.1e-05 24.5 0.0 0.12 12.3 0.0 3.1 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A V_ATPase_I_N PF18670.1 EFE44372.1 - 0.00049 20.4 0.2 0.001 19.4 0.2 1.5 1 0 0 1 1 1 1 V-type ATPase subunit I, N-terminal domain Cytochrom_D1 PF02239.16 EFE44372.1 - 0.0006 18.5 0.0 0.19 10.2 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 EFE44372.1 - 0.0046 16.3 0.0 1.2 8.4 0.0 2.4 1 1 1 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 EFE44372.1 - 0.022 13.7 0.1 0.058 12.4 0.1 1.7 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HPS3_N PF14761.6 EFE44372.1 - 0.026 14.1 0.0 4.8 6.7 0.0 2.9 1 1 2 3 3 3 0 Hermansky-Pudlak syndrome 3 Frtz PF11768.8 EFE44372.1 - 0.15 10.4 0.0 0.23 9.7 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 EFE44372.1 - 0.18 10.9 0.1 0.3 10.1 0.1 1.3 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain zf-RING_5 PF14634.6 EFE44373.1 - 0.00051 20.0 1.6 0.00095 19.1 1.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFE44373.1 - 0.018 15.4 0.6 0.047 14.0 0.6 1.7 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EFE44373.1 - 0.021 14.7 0.6 0.11 12.3 0.1 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFE44373.1 - 0.024 14.7 0.4 0.057 13.4 0.4 1.7 1 0 0 1 1 1 0 RING-type zinc-finger FYVE PF01363.21 EFE44373.1 - 0.042 14.0 1.1 0.1 12.7 1.1 1.7 1 0 0 1 1 1 0 FYVE zinc finger CwfJ_C_2 PF04676.14 EFE44373.1 - 0.13 13.2 0.0 0.37 11.7 0.1 1.8 2 0 0 2 2 2 0 Protein similar to CwfJ C-terminus 2 Noggin PF05806.12 EFE44373.1 - 0.19 11.6 2.5 0.17 11.8 0.9 1.6 2 0 0 2 2 2 0 Noggin GET2 PF08690.10 EFE44373.1 - 0.22 11.1 1.9 0.4 10.3 1.9 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 zf-C3HC4 PF00097.25 EFE44373.1 - 0.33 10.9 2.8 2.1 8.3 3.4 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFE44373.1 - 0.64 9.9 3.9 2.4 8.1 0.6 2.3 1 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EFE44373.1 - 0.69 9.8 5.2 6.9 6.6 5.4 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pex14_N PF04695.13 EFE44373.1 - 3.7 8.2 9.9 1.2 9.7 1.4 2.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region L51_S25_CI-B8 PF05047.16 EFE44374.1 - 1.1e-14 54.1 0.2 1.6e-14 53.5 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain U1snRNP70_N PF12220.8 EFE44375.1 - 6.1e-28 97.3 1.0 1.5e-27 96.0 1.0 1.7 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RL10P_insert PF17777.1 EFE44376.1 - 5.7e-22 77.5 0.0 1.2e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EFE44376.1 - 2.2e-18 66.2 0.0 5.3e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 Cyclin_N PF00134.23 EFE44377.1 - 5.1e-36 123.2 0.1 1.1e-35 122.1 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFE44377.1 - 1.7e-09 37.8 1.7 9.1e-09 35.4 1.7 2.1 1 1 0 1 1 1 1 Cyclin, C-terminal domain TMPIT PF07851.13 EFE44377.1 - 0.097 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 TMPIT-like protein Acyl_transf_3 PF01757.22 EFE44378.1 - 1.2e-24 87.0 23.3 2.1e-24 86.2 23.3 1.4 1 1 0 1 1 1 1 Acyltransferase family Caps_synth_CapC PF14102.6 EFE44378.1 - 0.14 12.6 0.2 0.14 12.6 0.2 2.5 3 0 0 3 3 3 0 Capsule biosynthesis CapC Pyr_redox_2 PF07992.14 EFE44379.1 - 9.8e-15 54.5 0.0 1.5e-09 37.6 0.0 2.0 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE44379.1 - 0.00085 18.7 1.2 0.059 12.6 1.2 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFE44379.1 - 0.0015 17.4 0.0 0.011 14.4 0.0 2.3 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EFE44379.1 - 0.0015 18.7 0.0 0.0035 17.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFE44379.1 - 0.018 14.6 0.2 0.044 13.4 0.1 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EFE44379.1 - 0.035 13.2 0.5 5.3 6.0 0.0 2.4 1 1 1 2 2 2 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EFE44379.1 - 0.074 13.0 0.4 2.2 8.2 0.1 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding Cytomega_UL20A PF05984.12 EFE44380.1 - 0.042 14.2 0.2 0.089 13.1 0.2 1.5 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein NAPRTase_N PF17767.1 EFE44382.1 - 0.002 18.5 0.8 0.0035 17.7 0.8 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain FKBP_C PF00254.28 EFE44383.1 - 2.1e-33 114.5 0.0 2.6e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Cyt-b5 PF00173.28 EFE44384.1 - 5.5e-17 61.7 0.0 8.1e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Beta-lactamase PF00144.24 EFE44385.1 - 1.6e-29 103.2 0.1 2.1e-29 102.8 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase Zip PF02535.22 EFE44386.1 - 2e-67 227.8 5.6 2.3e-67 227.6 5.6 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Tom37 PF10568.9 EFE44387.1 - 1.6e-17 64.0 0.0 3.5e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EFE44387.1 - 4.1e-10 39.3 0.0 2e-09 37.1 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain FNIP_N PF14636.6 EFE44389.1 - 0.17 12.8 4.1 0.23 12.4 4.1 1.3 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus DUF5411 PF17424.2 EFE44390.1 - 0.085 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5411) eIF3_subunit PF08597.10 EFE44391.1 - 0.046 13.6 7.2 0.048 13.6 0.1 2.2 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit NAPRTase PF04095.16 EFE44392.1 - 1.8e-56 191.5 0.1 4.8e-29 101.7 0.2 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EFE44392.1 - 3.5e-35 121.1 0.2 7.3e-35 120.1 0.2 1.6 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain DUF2960 PF11173.8 EFE44392.1 - 0.095 13.2 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2960) Syntaxin PF00804.25 EFE44393.1 - 4.2e-18 65.7 11.7 4.2e-18 65.7 11.7 1.9 2 1 0 2 2 2 1 Syntaxin Syntaxin_2 PF14523.6 EFE44393.1 - 1.3e-08 35.1 7.5 4.4e-08 33.4 0.5 2.7 2 1 1 3 3 3 1 Syntaxin-like protein SNARE PF05739.19 EFE44393.1 - 3.5e-08 33.3 3.8 3.5e-08 33.3 3.8 3.2 2 1 1 3 3 3 1 SNARE domain Use1 PF09753.9 EFE44393.1 - 1.5e-06 28.1 5.2 2.2e-06 27.6 5.2 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 MCU PF04678.13 EFE44393.1 - 0.0027 17.8 6.8 0.003 17.7 0.6 2.5 2 1 0 2 2 2 1 Mitochondrial calcium uniporter Spectrin PF00435.21 EFE44393.1 - 0.0029 18.1 7.8 0.56 10.7 0.0 3.3 2 1 0 3 3 3 2 Spectrin repeat COG2 PF06148.11 EFE44393.1 - 0.0063 16.6 5.6 0.0071 16.4 0.1 2.8 2 2 1 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 TRP PF06011.12 EFE44393.1 - 0.014 14.1 0.0 0.016 14.0 0.0 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF2207 PF09972.9 EFE44393.1 - 0.018 13.8 0.0 0.033 13.0 0.0 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) ETRAMP PF09716.10 EFE44393.1 - 0.049 13.7 0.0 0.073 13.1 0.0 1.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) SP_C-Propep PF08999.10 EFE44393.1 - 0.058 13.2 2.5 0.1 12.4 2.5 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Gp-FAR-1 PF05823.12 EFE44393.1 - 0.06 13.7 4.1 0.33 11.3 0.2 2.4 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Orf78 PF06024.12 EFE44393.1 - 0.064 13.6 0.4 0.064 13.6 0.4 2.2 2 1 0 2 2 2 0 Orf78 (ac78) DUF5345 PF17280.2 EFE44393.1 - 0.071 13.1 2.3 0.081 12.9 0.2 2.2 2 0 0 2 2 1 0 Family of unknown function (DUF5345) CENP-H PF05837.12 EFE44393.1 - 0.08 13.4 10.1 0.59 10.6 0.5 2.7 1 1 2 3 3 3 0 Centromere protein H (CENP-H) MT0933_antitox PF14013.6 EFE44393.1 - 0.082 13.2 0.7 0.43 10.9 0.2 2.5 2 0 0 2 2 2 0 MT0933-like antitoxin protein PBP1_TM PF14812.6 EFE44393.1 - 0.11 12.8 0.1 0.11 12.8 0.1 2.7 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Baculo_11_kDa PF06143.11 EFE44393.1 - 0.25 11.0 5.4 1 9.0 5.4 2.1 1 0 0 1 1 1 0 Baculovirus 11 kDa family Fusion_F0 PF13044.6 EFE44393.1 - 0.31 9.6 3.1 0.35 9.5 1.7 1.7 2 0 0 2 2 2 0 Fusion glycoprotein F0, Isavirus Fib_alpha PF08702.10 EFE44393.1 - 0.39 10.9 12.1 1.2 9.4 0.3 3.1 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Pox_EPC_I2-L1 PF12575.8 EFE44393.1 - 0.42 10.9 2.9 0.64 10.3 1.9 1.8 2 0 0 2 2 1 0 Poxvirus entry protein complex L1 and I2 Tweety PF04906.13 EFE44393.1 - 0.55 8.8 3.7 0.35 9.5 1.4 1.7 2 0 0 2 2 2 0 Tweety Baculo_F PF12259.8 EFE44393.1 - 0.69 8.4 13.6 0.43 9.0 0.0 2.7 1 1 2 3 3 3 0 Baculovirus F protein zf-CpG_bind_C PF12269.8 EFE44393.1 - 0.7 9.6 8.5 3 7.6 0.7 2.2 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain Gp58 PF07902.11 EFE44393.1 - 0.8 7.9 9.1 1 7.6 9.1 1.3 1 1 0 1 1 1 0 gp58-like protein DUF4407 PF14362.6 EFE44393.1 - 1.5 8.1 12.2 13 5.0 12.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ISG65-75 PF11727.8 EFE44393.1 - 2.2 7.5 9.1 8.2 5.6 2.6 2.5 2 1 0 2 2 2 0 Invariant surface glycoprotein BLOC1_2 PF10046.9 EFE44393.1 - 2.8 8.3 6.6 3.2 8.1 0.6 3.2 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSC22 PF01166.18 EFE44393.1 - 3.2 8.1 6.5 1.2 9.5 0.2 2.9 3 0 0 3 3 2 0 TSC-22/dip/bun family TMPIT PF07851.13 EFE44393.1 - 4.4 6.5 9.3 3.3 6.9 0.5 2.3 1 1 0 2 2 2 0 TMPIT-like protein 7tm_7 PF08395.12 EFE44393.1 - 5.2 6.2 8.7 2.1 7.5 0.5 2.7 3 0 0 3 3 3 0 7tm Chemosensory receptor HisKA_3 PF07730.13 EFE44393.1 - 6.1 7.5 9.2 3.4 8.3 0.2 4.0 2 1 2 5 5 5 0 Histidine kinase zf-C4H2 PF10146.9 EFE44393.1 - 6.8 6.9 12.7 9.8 6.4 1.8 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein FUSC PF04632.12 EFE44393.1 - 6.8 5.1 8.6 14 4.1 6.3 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family AMP-binding PF00501.28 EFE44394.1 - 5.8e-56 189.9 0.0 1.2e-55 188.8 0.0 1.4 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE44394.1 - 1.2e-11 45.4 0.0 2.2e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain IF4E PF01652.18 EFE44395.1 - 2.5e-52 176.9 1.7 3.2e-52 176.5 1.7 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Mpv17_PMP22 PF04117.12 EFE44396.1 - 4.9e-17 61.9 2.9 9.4e-16 57.8 0.1 2.5 2 0 0 2 2 2 2 Mpv17 / PMP22 family Ribosomal_S5 PF00333.20 EFE44397.1 - 1.3e-27 95.6 2.1 9.2e-27 92.8 1.0 2.5 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EFE44397.1 - 9.9e-22 76.2 0.0 1.6e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 EFE44397.1 - 2.6 8.6 11.0 6.2 7.4 11.0 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Bac_rhodopsin PF01036.18 EFE44399.1 - 1.4e-30 106.6 7.6 1.5e-30 106.4 7.6 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Glycos_transf_4 PF00953.21 EFE44399.1 - 0.002 18.1 0.7 0.002 18.1 0.7 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 4 DUF2391 PF09622.10 EFE44399.1 - 0.033 13.5 2.8 0.042 13.2 1.6 1.6 1 1 1 2 2 2 0 Putative integral membrane protein (DUF2391) Phage_holin_3_6 PF07332.11 EFE44399.1 - 0.036 14.1 1.5 0.036 14.1 1.5 2.2 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4579 PF15158.6 EFE44399.1 - 1.1 9.0 6.1 0.94 9.2 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4579) DUF3938 PF13074.6 EFE44399.1 - 1.5 9.1 7.2 0.13 12.5 2.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3938) tRNA-synt_1 PF00133.22 EFE44400.1 - 6.3e-161 536.6 0.0 8.3e-161 536.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFE44400.1 - 1e-21 77.5 0.6 2.1e-21 76.5 0.6 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFE44400.1 - 4.2e-20 71.9 0.0 6.3e-13 48.2 0.0 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFE44400.1 - 0.065 12.6 0.0 3.2 7.0 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain zf-FPG_IleRS PF06827.14 EFE44400.1 - 0.092 12.6 3.0 0.2 11.5 3.0 1.6 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS tRNA-synt_1_2 PF13603.6 EFE44400.1 - 0.14 11.6 0.0 0.37 10.3 0.0 1.6 2 0 0 2 2 2 0 Leucyl-tRNA synthetase, Domain 2 UPF0183 PF03676.14 EFE44401.1 - 2.6e-63 214.6 0.0 1.8e-40 139.4 0.0 2.6 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0183) Kinesin PF00225.23 EFE44402.1 - 1.1e-106 356.5 0.3 3e-106 355.1 0.3 1.8 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFE44402.1 - 1e-25 90.4 0.0 6.8e-25 87.8 0.0 2.5 1 0 0 1 1 1 1 Microtubule binding Microtub_bind PF13931.6 EFE44402.1 - 2.1e-07 31.4 1.0 2.1e-07 31.4 1.0 5.0 4 1 0 5 5 5 1 Kinesin-associated microtubule-binding Baculo_PEP_C PF04513.12 EFE44402.1 - 0.2 11.7 0.1 0.2 11.7 0.1 4.8 3 3 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus LPP PF04728.13 EFE44402.1 - 0.87 10.0 6.3 0.28 11.6 0.3 3.4 3 0 0 3 3 3 0 Lipoprotein leucine-zipper DUF4578 PF15147.6 EFE44403.1 - 7.3 7.5 7.5 2.1 9.2 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) Rhodanese PF00581.20 EFE44404.1 - 7.2e-20 71.5 0.0 4.8e-10 39.9 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain PIN_4 PF13638.6 EFE44405.1 - 2.5e-05 24.6 0.0 0.019 15.3 0.0 2.6 2 1 1 3 3 3 2 PIN domain NYN_YacP PF05991.11 EFE44405.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 YacP-like NYN domain DUF2007 PF09413.10 EFE44407.1 - 0.037 14.2 0.0 0.99 9.6 0.0 2.5 2 0 0 2 2 2 0 Putative prokaryotic signal transducing protein Metallophos PF00149.28 EFE44408.1 - 8.3e-10 39.5 0.8 1.3e-09 38.9 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFE44408.1 - 3.6e-07 30.5 0.1 4.2e-06 27.0 0.1 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain RPEL PF02755.15 EFE44410.1 - 1.6e-27 94.3 1.8 1.1e-07 31.3 0.1 3.4 3 0 0 3 3 3 3 RPEL repeat Rotamase_3 PF13616.6 EFE44410.1 - 0.0087 16.6 0.5 0.037 14.6 0.1 1.9 1 1 1 2 2 2 1 PPIC-type PPIASE domain Translin PF01997.16 EFE44411.1 - 2.8e-61 207.1 0.4 3.8e-61 206.6 0.4 1.2 1 0 0 1 1 1 1 Translin family Mannosyl_trans PF05007.13 EFE44412.1 - 6.4e-69 232.7 9.9 6.4e-69 232.7 9.9 1.6 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EFE44412.1 - 3e-12 46.3 0.9 3e-12 46.3 0.9 2.1 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EFE44412.1 - 2.1e-06 27.6 4.8 2.1e-06 27.6 4.8 2.6 2 1 1 3 3 3 1 Glycosyltransferase family 87 F-box-like PF12937.7 EFE44413.1 - 0.0031 17.4 0.0 0.013 15.4 0.0 2.1 1 1 0 1 1 1 1 F-box-like Fungal_trans PF04082.18 EFE44414.1 - 1.1e-11 44.2 0.0 1.8e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain SQS_PSY PF00494.19 EFE44415.1 - 7.5e-38 130.5 0.0 1.3e-37 129.8 0.0 1.4 2 0 0 2 2 2 1 Squalene/phytoene synthase DUF4328 PF14219.6 EFE44415.1 - 0.23 11.0 0.0 0.35 10.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) MAJIN PF15077.6 EFE44416.1 - 0.083 12.7 1.3 0.11 12.3 1.3 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Amidohydro_1 PF01979.20 EFE44417.1 - 6.1e-10 38.9 0.2 1.3e-09 37.8 0.2 1.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.14 EFE44417.1 - 4.9e-08 33.1 0.0 8.8e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase CoA_binding_2 PF13380.6 EFE44417.1 - 0.0035 17.8 0.2 0.041 14.4 0.1 2.4 2 1 1 3 3 3 1 CoA binding domain DnaJ-X PF14308.6 EFE44418.1 - 1.9e-79 266.0 5.7 1.9e-79 266.0 5.7 3.0 3 1 0 3 3 3 1 X-domain of DnaJ-containing DnaJ PF00226.31 EFE44418.1 - 4.3e-25 87.6 0.3 1.1e-24 86.3 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain Condensin2nSMC PF12422.8 EFE44418.1 - 0.038 14.2 0.2 0.12 12.5 0.1 2.0 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit OrfB_IS605 PF01385.19 EFE44418.1 - 0.27 11.5 2.2 0.69 10.1 2.2 1.6 1 0 0 1 1 1 0 Probable transposase MAP1B_neuraxin PF00414.17 EFE44419.1 - 5.5 6.7 7.3 15 5.4 1.2 2.9 2 0 0 2 2 2 0 Neuraxin and MAP1B repeat IMS PF00817.20 EFE44420.1 - 5.6e-42 143.3 1.0 1.1e-41 142.4 0.3 1.9 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 EFE44420.1 - 2.4e-14 54.0 0.2 6.9e-14 52.6 0.2 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EFE44420.1 - 3.6e-05 23.8 0.0 0.0001 22.4 0.0 1.9 1 0 0 1 1 1 1 IMS family HHH motif NIBRIN_BRCT_II PF16508.5 EFE44421.1 - 3.5e-29 101.5 0.0 7.2e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 Second BRCT domain on Nijmegen syndrome breakage protein DUF4138 PF13595.6 EFE44421.1 - 0.097 11.9 0.0 0.25 10.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4138) Acetyltransf_1 PF00583.25 EFE44422.1 - 2.2e-08 34.3 0.1 4.1e-08 33.5 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFE44422.1 - 1.2e-07 31.7 0.0 2.6e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFE44422.1 - 9.7e-06 25.9 0.5 1.9e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFE44422.1 - 0.058 13.5 0.0 0.65 10.1 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Ferritin_2 PF13668.6 EFE44423.1 - 3e-13 50.1 0.3 6.1e-13 49.1 0.3 1.4 1 0 0 1 1 1 1 Ferritin-like domain Sugar_tr PF00083.24 EFE44424.1 - 1.6e-21 76.7 22.7 8.7e-12 44.6 7.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter Pkinase PF00069.25 EFE44425.1 - 1.4e-29 103.2 0.0 1e-28 100.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44425.1 - 2.8e-11 43.2 0.0 2.9e-06 26.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase AMP-binding PF00501.28 EFE44426.1 - 2.9e-75 253.5 0.0 3.5e-75 253.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE44426.1 - 3.9e-12 47.0 0.9 8.7e-12 45.9 0.9 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.16 EFE44427.1 - 4.2e-39 134.5 26.7 4.2e-39 134.5 26.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily CLN3 PF02487.17 EFE44427.1 - 3.1e-05 23.2 0.1 0.0045 16.1 0.0 2.3 1 1 1 2 2 2 2 CLN3 protein Vac7 PF12751.7 EFE44429.1 - 8.6e-137 456.6 0.3 8.6e-137 456.6 0.3 3.2 2 1 1 3 3 3 1 Vacuolar segregation subunit 7 EIIBC-GUT_N PF03612.14 EFE44429.1 - 0.16 11.7 1.7 0.34 10.6 1.7 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CorA PF01544.18 EFE44430.1 - 1.7e-37 129.3 0.4 4.5e-37 128.0 0.4 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein adh_short PF00106.25 EFE44432.1 - 6.9e-36 123.5 0.1 9.8e-36 123.0 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE44432.1 - 1.2e-27 97.1 0.0 1.7e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE44432.1 - 4.4e-09 36.5 2.2 3.6e-07 30.3 3.1 2.8 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EFE44432.1 - 2.8e-05 23.7 0.0 7.9e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFE44432.1 - 0.005 16.0 0.0 0.0081 15.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain UPF0146 PF03686.13 EFE44432.1 - 0.016 15.1 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) DUF3216 PF11505.8 EFE44432.1 - 0.14 12.4 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) TPD PF14811.6 EFE44433.1 - 0.017 15.0 0.1 0.021 14.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function TPD sequence-motif Ribosomal_L19e PF01280.20 EFE44437.1 - 4.1e-62 208.5 6.9 4.1e-62 208.5 6.9 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e DUF4239 PF14023.6 EFE44437.1 - 0.13 12.0 1.4 0.24 11.1 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) TRAP-gamma PF07074.12 EFE44437.1 - 0.2 11.2 3.5 0.32 10.5 3.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Gcn1_N PF12074.8 EFE44438.1 - 3.9e-117 391.5 0.5 3.3e-116 388.5 0.0 3.1 2 0 0 2 2 2 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 EFE44438.1 - 7e-27 91.2 39.5 0.093 13.0 0.1 22.0 24 0 0 24 24 22 7 HEAT repeat HEAT_2 PF13646.6 EFE44438.1 - 1.9e-21 76.2 34.7 1.6e-05 25.2 0.0 13.8 9 4 8 18 18 18 7 HEAT repeats HEAT_EZ PF13513.6 EFE44438.1 - 1.6e-17 63.6 44.2 3.9e-07 30.4 0.0 17.9 23 1 1 24 24 19 3 HEAT-like repeat Cnd1 PF12717.7 EFE44438.1 - 1.4e-11 44.7 11.8 0.014 15.4 0.1 8.8 7 2 1 8 8 8 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFE44438.1 - 2.5e-11 44.0 0.0 3.4 8.3 0.0 8.2 6 1 2 8 8 8 2 Vacuolar 14 Fab1-binding region ParcG PF10274.9 EFE44438.1 - 6.3e-07 29.7 6.4 0.19 11.9 0.0 6.7 6 0 0 6 6 6 2 Parkin co-regulated protein TIP120 PF08623.10 EFE44438.1 - 1e-06 28.7 0.5 0.01 15.6 0.0 5.6 5 0 0 5 5 5 1 TATA-binding protein interacting (TIP20) CLASP_N PF12348.8 EFE44438.1 - 2.6e-06 27.2 0.0 1.7 8.1 0.0 6.5 5 1 1 6 6 6 1 CLASP N terminal DUF937 PF06078.11 EFE44438.1 - 0.001 19.7 1.3 6.7 7.3 0.0 5.1 3 1 0 3 3 3 1 Bacterial protein of unknown function (DUF937) Adaptin_N PF01602.20 EFE44438.1 - 0.0031 16.2 15.5 1.7 7.1 0.4 6.2 6 2 0 6 6 6 3 Adaptin N terminal region Pes-10 PF07149.11 EFE44438.1 - 0.018 14.1 0.1 0.047 12.7 0.1 1.7 1 0 0 1 1 1 0 Pes-10 RasGEF_N_2 PF14663.6 EFE44438.1 - 0.046 14.1 0.7 11 6.5 0.0 4.4 4 0 0 4 4 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Tti2 PF10521.9 EFE44438.1 - 0.052 13.1 5.6 15 5.1 0.1 5.9 5 1 0 5 5 5 0 Tti2 family RTP1_C1 PF10363.9 EFE44438.1 - 2 8.6 9.1 96 3.2 0.0 6.6 8 0 0 8 8 8 0 Required for nuclear transport of RNA pol II C-terminus 1 FANCI_S2 PF14676.6 EFE44438.1 - 5.7 7.2 8.7 18 5.6 0.1 4.3 5 0 0 5 5 5 0 FANCI solenoid 2 HA2 PF04408.23 EFE44439.1 - 6.1e-16 58.7 0.0 1.5e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFE44439.1 - 2.1e-13 50.6 0.0 5e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFE44439.1 - 4.5e-11 42.8 0.0 9.6e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFE44439.1 - 7.3e-08 32.8 0.2 3.8e-06 27.2 0.1 2.7 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFE44439.1 - 0.0035 16.4 0.0 0.0064 15.6 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_23 PF13476.6 EFE44439.1 - 0.011 16.2 0.1 0.011 16.2 0.1 2.5 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EFE44439.1 - 0.013 14.8 0.0 0.05 12.9 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATPase PF06745.13 EFE44439.1 - 0.02 14.3 0.1 0.18 11.1 0.0 2.3 2 0 0 2 2 2 0 KaiC ABC_tran PF00005.27 EFE44439.1 - 0.023 15.2 0.2 0.23 12.0 0.0 2.7 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.6 EFE44439.1 - 0.029 14.7 0.0 0.084 13.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFE44439.1 - 0.078 12.7 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rrn6 PF10214.9 EFE44441.1 - 0.38 9.2 9.4 0.35 9.3 9.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Cys_rich_VLP PF14194.6 EFE44442.1 - 0.14 12.3 1.3 0.37 11.0 1.3 1.7 1 0 0 1 1 1 0 Cysteine-rich VLP CHD5 PF04420.14 EFE44442.1 - 0.19 11.6 2.5 0.32 10.8 2.5 1.3 1 0 0 1 1 1 0 CHD5-like protein DUF2828 PF11443.8 EFE44442.1 - 1.8 6.6 7.0 2.4 6.2 7.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) N-SET PF11764.8 EFE44443.1 - 3.3e-58 196.6 0.4 1.6e-57 194.3 0.4 2.3 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 EFE44443.1 - 2.4e-27 94.3 0.3 6.1e-27 93.0 0.3 1.7 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated SET PF00856.28 EFE44443.1 - 9.3e-20 71.7 0.2 9.3e-20 71.7 0.2 3.5 4 0 0 4 4 4 1 SET domain RRM_1 PF00076.22 EFE44443.1 - 0.00059 19.6 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trm112p PF03966.16 EFE44444.1 - 8.2e-14 51.9 0.1 1e-13 51.6 0.1 1.1 1 0 0 1 1 1 1 Trm112p-like protein Rad60-SLD PF11976.8 EFE44445.1 - 1.8e-23 82.1 2.1 4.2e-19 68.2 1.2 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFE44445.1 - 6e-05 22.7 0.5 0.011 15.5 0.1 2.3 2 0 0 2 2 2 2 Ubiquitin family DUF853 PF05872.12 EFE44445.1 - 0.82 8.2 2.3 0.6 8.6 0.1 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) Rxt3 PF08642.10 EFE44445.1 - 3.1 8.6 8.6 4.1 8.2 0.4 3.0 3 0 0 3 3 3 0 Histone deacetylation protein Rxt3 SPT2 PF08243.11 EFE44445.1 - 3.3 8.3 17.9 0.053 14.0 6.8 3.1 3 0 0 3 3 3 0 SPT2 chromatin protein LSM PF01423.22 EFE44446.1 - 1.2e-16 60.1 0.0 1.4e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFE44446.1 - 0.0028 17.7 0.0 0.0035 17.5 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EFE44446.1 - 0.043 13.9 0.0 0.05 13.7 0.0 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain Hfq PF17209.3 EFE44446.1 - 0.11 12.2 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Hfq protein DUF1106 PF06523.11 EFE44446.1 - 0.18 11.9 0.0 0.21 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1106) SPAN PF02510.14 EFE44446.1 - 0.22 10.7 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 Surface presentation of antigens protein IF-2B PF01008.17 EFE44447.1 - 1.4e-69 234.5 0.7 1.6e-69 234.2 0.7 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family SbmA_BacA PF05992.12 EFE44447.1 - 0.031 13.7 0.1 0.068 12.6 0.1 1.5 1 0 0 1 1 1 0 SbmA/BacA-like family Pkinase PF00069.25 EFE44448.1 - 3.3e-13 49.6 0.0 7.1e-13 48.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44448.1 - 3.9e-10 39.4 0.0 9.8e-10 38.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE44448.1 - 0.00033 20.1 0.0 0.00044 19.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like GST_N PF02798.20 EFE44449.1 - 3e-14 53.1 0.0 5e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFE44449.1 - 4.3e-14 52.5 0.0 1.1e-13 51.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFE44449.1 - 4.2e-13 49.5 0.0 7e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFE44449.1 - 8.7e-09 35.5 0.0 1.6e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFE44449.1 - 1.1e-08 35.2 0.0 4.8e-08 33.2 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFE44449.1 - 2.2e-08 34.0 0.1 4.4e-08 33.0 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFE44449.1 - 0.067 13.9 0.0 0.22 12.3 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain Adaptin_N PF01602.20 EFE44450.1 - 7.7e-76 255.7 0.0 1.6e-75 254.7 0.0 1.5 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFE44450.1 - 1.4e-06 28.5 0.0 0.0028 17.7 0.0 2.3 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFE44450.1 - 0.015 15.5 0.1 20 5.8 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat TPR_14 PF13428.6 EFE44451.1 - 6.1e-09 36.0 1.3 0.015 16.0 0.0 4.6 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFE44451.1 - 2.5e-08 34.3 0.2 0.054 14.0 0.0 4.3 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFE44451.1 - 4.1e-06 26.6 0.0 0.0062 16.7 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFE44451.1 - 3.7e-05 23.8 0.0 0.14 12.6 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFE44451.1 - 5.2e-05 23.0 0.0 0.037 14.2 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EFE44451.1 - 0.0072 16.3 0.0 1.4 8.8 0.0 2.3 1 1 1 2 2 2 1 Virulence factor membrane-bound polymerase, C-terminal TPR_11 PF13414.6 EFE44451.1 - 0.014 15.1 0.1 2.6 7.8 0.1 3.5 2 1 1 3 3 3 0 TPR repeat TPR_16 PF13432.6 EFE44451.1 - 0.026 15.2 0.2 2.1 9.0 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFE44451.1 - 0.085 12.7 0.1 0.48 10.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFE44451.1 - 0.14 12.3 0.9 0.31 11.2 0.2 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFE44451.1 - 0.24 11.7 2.7 13 6.1 0.0 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat RNA_pol_3_Rpc31 PF11705.8 EFE44453.1 - 0.00032 21.0 1.0 0.00032 21.0 1.0 2.8 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 Borrelia_P83 PF05262.11 EFE44453.1 - 0.97 7.8 21.1 1.4 7.3 21.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein BAF1_ABF1 PF04684.13 EFE44453.1 - 1.2 8.1 8.5 0.13 11.3 3.5 1.8 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Spem1 PF15670.5 EFE44453.1 - 1.4 8.4 8.7 3.7 7.1 8.7 1.7 1 0 0 1 1 1 0 Spermatid maturation protein 1 EPO_TPO PF00758.18 EFE44454.1 - 0.018 15.1 0.2 0.029 14.4 0.1 1.3 1 1 0 1 1 1 0 Erythropoietin/thrombopoietin DRAT PF07357.11 EFE44454.1 - 0.026 13.8 0.1 0.032 13.4 0.1 1.2 1 0 0 1 1 1 0 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) Kinesin PF00225.23 EFE44455.1 - 4.5e-96 321.7 0.1 9.8e-96 320.6 0.1 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFE44455.1 - 2.6e-23 82.6 0.2 2.2e-21 76.4 0.0 2.6 3 0 0 3 3 3 1 Microtubule binding GNAT_acetyltr_2 PF13718.6 EFE44455.1 - 0.019 14.4 0.8 1 8.7 0.4 2.4 2 0 0 2 2 2 0 GNAT acetyltransferase 2 MoCF_biosynth PF00994.24 EFE44455.1 - 0.049 13.3 0.8 0.25 11.0 0.0 2.6 4 0 0 4 4 4 0 Probable molybdopterin binding domain MPS2 PF17060.5 EFE44455.1 - 0.052 12.8 0.0 0.052 12.8 0.0 1.8 2 0 0 2 2 2 0 Monopolar spindle protein 2 FlxA PF14282.6 EFE44455.1 - 0.13 12.2 7.2 0.13 12.3 1.8 3.4 3 0 0 3 3 3 0 FlxA-like protein Lebercilin PF15619.6 EFE44455.1 - 0.22 11.1 15.3 0.14 11.8 1.6 2.7 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF641 PF04859.12 EFE44455.1 - 0.52 10.7 7.5 2 8.8 0.4 3.4 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Tho2 PF11262.8 EFE44455.1 - 1.1 8.4 4.3 1.9 7.6 4.3 1.4 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 BBP1_C PF15272.6 EFE44455.1 - 5.3 6.8 12.7 3.8 7.3 0.9 3.3 3 0 0 3 3 3 0 Spindle pole body component BBP1, C-terminal Ank_2 PF12796.7 EFE44456.1 - 6.2e-82 270.3 15.3 3.4e-16 59.6 0.2 6.3 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE44456.1 - 1.1e-55 185.2 1.2 4.3e-10 39.9 0.1 8.3 4 2 4 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE44456.1 - 1.2e-44 145.1 7.4 0.00034 20.8 0.0 12.1 12 0 0 12 12 12 10 Ankyrin repeat Ank PF00023.30 EFE44456.1 - 4.3e-43 143.9 14.5 1.2e-05 25.5 0.0 12.2 12 0 0 12 12 12 10 Ankyrin repeat Ank_5 PF13857.6 EFE44456.1 - 1.9e-41 139.6 10.8 2.3e-10 40.5 0.0 7.5 3 1 6 9 9 9 8 Ankyrin repeats (many copies) PEGA PF08308.11 EFE44456.1 - 0.0014 18.5 0.0 12 5.9 0.0 4.3 5 0 0 5 5 5 1 PEGA domain F-box-like PF12937.7 EFE44456.1 - 0.016 15.1 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 F-box-like NOGCT PF08155.11 EFE44457.1 - 0.084 12.9 0.1 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 NOGCT (NUC087) domain DAGAT PF03982.13 EFE44458.1 - 1.8e-91 306.2 0.0 2e-91 306.0 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase UBA_e1_thiolCys PF10585.9 EFE44459.1 - 0.17 11.8 0.7 9.1 6.1 0.0 2.8 2 1 0 3 3 3 0 Ubiquitin-activating enzyme active site Asp-B-Hydro_N PF05279.11 EFE44460.1 - 0.48 10.5 26.7 0.61 10.1 26.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF966 PF06136.13 EFE44460.1 - 0.54 9.9 23.0 0.68 9.6 23.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CRT10 PF08728.10 EFE44460.1 - 1.2 7.3 9.5 1.3 7.2 9.5 1.1 1 0 0 1 1 1 0 CRT10 Coilin_N PF15862.5 EFE44460.1 - 1.5 8.6 37.5 0.093 12.5 10.4 2.2 2 0 0 2 2 2 0 Coilin N-terminus DUF4551 PF15087.6 EFE44460.1 - 3.7 6.3 17.0 4.5 6.0 17.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) LAP1C PF05609.12 EFE44460.1 - 5.1 6.1 24.6 6.4 5.7 24.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 EFE44460.1 - 5.3 5.5 20.3 6.7 5.1 20.3 1.1 1 0 0 1 1 1 0 Macoilin family DUF2852 PF11014.8 EFE44461.1 - 0.43 10.8 6.3 0.78 9.9 5.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2852) Fib_alpha PF08702.10 EFE44461.1 - 6.4 7.0 11.1 6.6 6.9 9.5 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Syja_N PF02383.18 EFE44462.1 - 2.1e-71 240.9 0.0 3.2e-71 240.3 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EFE44462.1 - 1.3e-10 41.3 0.0 2e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.25 EFE44463.1 - 2e-62 211.0 0.0 2.4e-62 210.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44463.1 - 1.5e-34 119.4 0.0 2.1e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE44463.1 - 0.095 12.0 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFE44463.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE44463.1 - 0.19 10.5 0.0 0.28 9.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase IGR PF09597.10 EFE44464.1 - 2.9e-22 78.5 2.3 5.4e-22 77.6 2.3 1.5 1 0 0 1 1 1 1 IGR protein motif p450 PF00067.22 EFE44465.1 - 4.6e-70 236.6 0.0 6e-70 236.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 K-box PF01486.17 EFE44465.1 - 0.14 12.4 0.1 0.33 11.2 0.1 1.5 1 0 0 1 1 1 0 K-box region Pkinase PF00069.25 EFE44466.1 - 2.4e-61 207.4 0.0 4.4e-60 203.3 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44466.1 - 4.5e-30 104.8 0.3 8.1e-28 97.4 0.3 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EFE44466.1 - 8.3e-16 58.1 0.2 2.4e-15 56.6 0.2 1.9 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EFE44466.1 - 0.00027 20.3 1.5 0.61 9.3 0.5 3.1 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFE44466.1 - 0.00043 19.2 0.0 0.00074 18.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Yop-YscD_cpl PF16697.5 EFE44466.1 - 0.0011 19.2 0.0 0.0035 17.6 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Haspin_kinase PF12330.8 EFE44466.1 - 0.0095 14.9 0.2 0.014 14.3 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFE44466.1 - 0.02 14.3 0.1 0.031 13.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EFE44466.1 - 0.077 12.0 0.1 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PI3_PI4_kinase PF00454.27 EFE44467.1 - 1.4e-37 129.8 0.0 4.7e-35 121.6 0.0 2.8 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFE44467.1 - 4.4e-24 84.9 0.0 1e-23 83.7 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EFE44467.1 - 0.074 12.4 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Pkinase PF00069.25 EFE44468.1 - 3.7e-08 33.0 0.0 0.00096 18.6 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Chorion_2 PF03964.15 EFE44470.1 - 0.025 15.4 6.1 0.025 15.4 6.1 2.6 2 1 0 2 2 2 0 Chorion family 2 ArfGap PF01412.18 EFE44471.1 - 2e-32 111.7 0.0 2e-32 111.7 0.0 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EFE44471.1 - 4.1e-18 66.0 7.0 7e-18 65.2 7.0 1.3 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EFE44471.1 - 1.4e-08 35.1 0.1 5.3e-08 33.3 0.1 2.0 1 0 0 1 1 1 1 PH domain Chromo PF00385.24 EFE44472.1 - 0.018 14.9 1.1 0.018 14.9 1.1 2.0 1 1 1 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain R3H PF01424.22 EFE44472.1 - 0.17 11.9 0.0 2.6 8.1 0.0 2.1 2 0 0 2 2 2 0 R3H domain Ank_2 PF12796.7 EFE44473.1 - 7e-52 174.0 0.5 3.5e-12 46.7 0.0 5.9 3 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFE44473.1 - 5.5e-46 154.4 5.8 4.6e-08 33.5 0.5 10.5 3 1 9 12 12 12 11 Ankyrin repeats (many copies) Ank PF00023.30 EFE44473.1 - 1.1e-36 123.7 11.2 8.1e-08 32.4 0.0 10.8 11 0 0 11 11 11 7 Ankyrin repeat Ank_3 PF13606.6 EFE44473.1 - 6.1e-36 118.4 3.5 0.00018 21.7 0.1 12.0 13 0 0 13 13 13 8 Ankyrin repeat Ank_5 PF13857.6 EFE44473.1 - 1.1e-28 98.9 10.1 3.1e-06 27.3 0.0 8.5 5 2 5 10 10 10 7 Ankyrin repeats (many copies) Asp_protease_2 PF13650.6 EFE44473.1 - 0.055 14.1 0.2 13 6.5 0.0 4.1 3 1 0 3 3 3 0 Aspartyl protease RVP PF00077.20 EFE44473.1 - 0.099 13.0 0.0 11 6.4 0.0 3.3 3 1 0 3 3 3 0 Retroviral aspartyl protease NLRC4_HD2 PF17776.1 EFE44474.1 - 0.079 13.5 0.1 0.17 12.4 0.1 1.6 1 0 0 1 1 1 0 NLRC4 helical domain HD2 Fungal_trans_2 PF11951.8 EFE44475.1 - 4.3e-24 85.0 0.5 1.3e-23 83.5 0.5 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE44475.1 - 8.4e-09 35.4 9.0 1.4e-08 34.7 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease PF00324.21 EFE44476.1 - 1.3e-141 472.5 36.0 1.5e-141 472.3 36.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE44476.1 - 4.6e-34 118.0 36.6 6.3e-34 117.5 36.6 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 EFE44476.1 - 7.6 5.2 5.9 1.4 7.6 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) APH PF01636.23 EFE44477.1 - 8.4e-10 39.0 0.0 6.8e-07 29.5 0.0 2.6 3 0 0 3 3 3 2 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE44477.1 - 0.00018 20.5 0.1 0.28 10.0 0.0 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.14 EFE44477.1 - 0.018 14.3 0.0 0.7 9.0 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase EcKinase PF02958.20 EFE44477.1 - 0.077 12.3 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase DLP_helical PF18709.1 EFE44478.1 - 0.015 14.5 0.0 0.036 13.3 0.0 1.6 1 1 0 1 1 1 0 Dynamin-like helical domain PLC-beta_C PF08703.10 EFE44478.1 - 0.03 14.3 0.8 0.044 13.8 0.8 1.2 1 0 0 1 1 1 0 PLC-beta C terminal RhoGAP PF00620.27 EFE44479.1 - 8.8e-14 51.6 0.2 3.3e-13 49.7 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain DEP PF00610.21 EFE44479.1 - 2.5e-09 37.0 0.0 5.4e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 EFE44479.1 - 2.7e-09 37.2 0.3 2.7e-08 34.0 0.0 2.8 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain TIP120 PF08623.10 EFE44479.1 - 0.0086 15.9 0.2 0.5 10.1 0.0 2.6 2 0 0 2 2 2 1 TATA-binding protein interacting (TIP20) YojJ PF10372.9 EFE44479.1 - 0.022 14.8 1.2 0.24 11.5 0.5 2.8 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus RTA1 PF04479.13 EFE44480.1 - 1.4e-23 83.6 7.1 5.5e-18 65.3 2.2 2.2 1 1 1 2 2 2 2 RTA1 like protein Asp-Al_Ex PF06826.12 EFE44480.1 - 0.02 14.7 0.4 0.036 13.9 0.4 1.4 1 0 0 1 1 1 0 Predicted Permease Membrane Region AAA PF00004.29 EFE44481.1 - 1.7e-14 54.3 0.0 4e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFE44481.1 - 3.1e-13 50.2 0.0 8.1e-13 48.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFE44481.1 - 1.8e-12 48.0 0.5 3.2e-11 43.9 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain Cdc6_C PF09079.11 EFE44481.1 - 1.5e-08 34.5 0.0 3.7e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain TniB PF05621.11 EFE44481.1 - 7.7e-06 25.4 0.0 1.4e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein TIP49 PF06068.13 EFE44481.1 - 0.0002 20.7 0.0 0.00033 20.0 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_19 PF13245.6 EFE44481.1 - 0.00042 20.7 0.0 0.0011 19.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EFE44481.1 - 0.00051 20.0 0.0 0.00095 19.1 0.0 1.5 1 0 0 1 1 1 1 NTPase AAA_7 PF12775.7 EFE44481.1 - 0.00089 18.8 0.0 0.0018 17.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_lid_10 PF17872.1 EFE44481.1 - 0.0013 18.8 0.0 0.0032 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA lid domain PIF1 PF05970.14 EFE44481.1 - 0.002 17.4 0.0 0.0035 16.6 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase T2SSE PF00437.20 EFE44481.1 - 0.0024 17.0 0.0 0.0048 16.0 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_5 PF07728.14 EFE44481.1 - 0.0033 17.4 0.0 0.0073 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EFE44481.1 - 0.0039 16.9 0.0 0.0083 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EFE44481.1 - 0.0048 16.1 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain RuvB_N PF05496.12 EFE44481.1 - 0.0076 16.0 0.0 0.022 14.5 0.0 1.7 1 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EFE44481.1 - 0.0095 16.3 0.0 0.02 15.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 EFE44481.1 - 0.011 16.3 0.0 0.02 15.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFE44481.1 - 0.016 15.7 0.0 0.042 14.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter ATPase_2 PF01637.18 EFE44481.1 - 0.018 15.0 0.0 0.033 14.1 0.0 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 EFE44481.1 - 0.02 14.1 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain AAA_14 PF13173.6 EFE44481.1 - 0.029 14.4 0.0 0.069 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFE44481.1 - 0.036 13.8 0.0 0.075 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFE44481.1 - 0.042 13.8 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_28 PF13521.6 EFE44481.1 - 0.054 13.7 0.0 0.21 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain RNA12 PF10443.9 EFE44481.1 - 0.063 12.0 0.0 0.094 11.4 0.0 1.3 1 0 0 1 1 1 0 RNA12 protein NACHT PF05729.12 EFE44481.1 - 0.1 12.5 0.1 0.49 10.3 0.1 2.0 1 1 0 1 1 1 0 NACHT domain Herpes_US12 PF05363.12 EFE44481.1 - 0.8 10.5 4.5 27 5.6 0.1 3.5 3 0 0 3 3 3 0 Herpesvirus US12 family Thioredoxin_7 PF13899.6 EFE44482.1 - 2.2e-15 56.6 0.0 4.5e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EFE44482.1 - 4.2e-14 52.1 0.1 8e-14 51.2 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EFE44482.1 - 2.5e-07 30.8 0.0 1.3e-06 28.6 0.0 2.2 2 0 0 2 2 2 1 UBX domain Thioredoxin_2 PF13098.6 EFE44482.1 - 0.099 13.1 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain Pkinase PF00069.25 EFE44484.1 - 4.9e-62 209.7 0.0 7.4e-62 209.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44484.1 - 2.2e-46 158.2 0.0 3.5e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE44484.1 - 6e-06 25.3 0.5 4.8e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFE44484.1 - 0.19 11.0 0.0 0.45 9.8 0.0 1.6 1 0 0 1 1 1 0 Kinase-like COesterase PF00135.28 EFE44485.1 - 5.8e-56 190.4 0.0 1.3e-55 189.2 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFE44485.1 - 1.9e-09 37.7 0.0 3e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Fungal_trans PF04082.18 EFE44486.1 - 2.2e-17 63.0 0.0 3.1e-10 39.5 0.0 2.2 1 1 1 2 2 2 2 Fungal specific transcription factor domain MR_MLE_C PF13378.6 EFE44487.1 - 2.1e-41 141.9 0.0 2.9e-41 141.4 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EFE44487.1 - 0.0039 17.4 0.2 0.013 15.7 0.0 1.8 1 1 1 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Beta-lactamase PF00144.24 EFE44488.1 - 4.4e-28 98.5 0.0 8e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase adh_short_C2 PF13561.6 EFE44489.1 - 2.4e-43 148.4 0.0 3.2e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE44489.1 - 5.8e-31 107.5 0.0 8.7e-31 106.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE44489.1 - 0.0051 16.7 0.0 0.0078 16.1 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF3431 PF11913.8 EFE44490.1 - 6e-85 284.4 0.1 7.4e-85 284.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) FlxA PF14282.6 EFE44490.1 - 0.17 11.9 0.5 0.31 11.0 0.5 1.3 1 0 0 1 1 1 0 FlxA-like protein Amidohydro_2 PF04909.14 EFE44493.1 - 9.8e-13 48.5 0.0 1.4e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase Spt5-NGN PF03439.13 EFE44493.1 - 0.15 11.9 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Early transcription elongation factor of RNA pol II, NGN section ADH_zinc_N PF00107.26 EFE44494.1 - 1.8e-23 83.0 0.4 2.7e-23 82.4 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE44494.1 - 3.3e-17 62.3 0.7 8.3e-17 61.1 0.7 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFE44494.1 - 0.00012 23.1 0.1 0.00021 22.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_32 PF13679.6 EFE44494.1 - 0.083 12.9 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain v110 PF01639.17 EFE44494.1 - 0.099 12.5 0.6 0.17 11.7 0.6 1.3 1 0 0 1 1 1 0 Viral family 110 Glu_dehyd_C PF16912.5 EFE44494.1 - 0.16 11.5 0.3 0.41 10.1 0.3 1.6 1 1 0 1 1 1 0 Glucose dehydrogenase C-terminus RecC_C PF17946.1 EFE44495.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 RecC C-terminal domain EIF_2_alpha PF07541.12 EFE44495.1 - 0.17 12.0 0.0 0.98 9.5 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit SET PF00856.28 EFE44496.1 - 3.6e-09 37.2 1.7 4e-07 30.6 0.0 3.7 2 1 1 3 3 3 2 SET domain TPR_1 PF00515.28 EFE44496.1 - 0.017 14.9 0.1 0.14 12.1 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFE44496.1 - 0.027 14.6 0.0 0.064 13.4 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Defensin_int PF17858.1 EFE44496.1 - 0.041 13.9 1.1 0.13 12.3 1.1 1.8 1 0 0 1 1 1 0 Platypus intermediate defensin-like peptide SAP PF02037.27 EFE44496.1 - 0.064 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 SAP domain Allexi_40kDa PF05549.11 EFE44497.1 - 0.045 13.3 0.0 0.045 13.3 0.0 3.5 3 0 0 3 3 3 0 Allexivirus 40kDa protein Prenylcys_lyase PF07156.14 EFE44497.1 - 0.47 9.5 2.5 0.41 9.7 0.6 1.8 2 0 0 2 2 2 0 Prenylcysteine lyase zf-H2C2_2 PF13465.6 EFE44499.1 - 2.7e-10 40.2 16.2 8.3e-05 22.8 1.5 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EFE44499.1 - 1.8e-07 31.2 23.9 0.021 15.3 7.0 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFE44499.1 - 0.00016 22.3 20.9 0.14 13.1 5.6 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-Di19 PF05605.12 EFE44499.1 - 0.012 15.9 6.3 0.022 15.1 6.3 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EFE44499.1 - 0.013 15.5 19.2 0.12 12.4 0.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Rad50_zn_hook PF04423.14 EFE44499.1 - 0.066 13.1 0.4 0.16 11.8 0.4 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-C2H2_jaz PF12171.8 EFE44499.1 - 0.098 13.0 7.4 1.5 9.2 2.4 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 EFE44499.1 - 0.16 11.8 6.9 3.4 7.5 1.6 2.9 1 1 1 2 2 2 0 GAGA factor DUF3268 PF11672.8 EFE44499.1 - 0.23 11.8 1.1 0.41 11.0 1.1 1.4 1 0 0 1 1 1 0 zinc-finger-containing domain zf-C2HE PF16278.5 EFE44499.1 - 0.24 11.9 15.0 0.36 11.3 1.1 3.1 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_9 PF16293.5 EFE44499.1 - 0.38 10.6 1.9 2.1 8.3 0.2 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) Zn-ribbon_8 PF09723.10 EFE44499.1 - 0.39 10.9 6.6 0.48 10.6 1.3 2.7 1 1 2 3 3 3 0 Zinc ribbon domain FYDLN_acid PF09538.10 EFE44499.1 - 0.6 10.8 2.6 16 6.2 0.7 3.0 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) DZR PF12773.7 EFE44499.1 - 0.64 10.1 6.6 6.1 6.9 6.5 2.2 1 1 1 2 2 2 0 Double zinc ribbon CCDC106 PF15794.5 EFE44499.1 - 0.79 9.4 0.0 0.79 9.4 0.0 2.3 3 0 0 3 3 2 0 Coiled-coil domain-containing protein 106 zf_C2H2_ZHX PF18387.1 EFE44499.1 - 2.3 7.9 8.4 7.8 6.2 0.0 3.3 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-BED PF02892.15 EFE44499.1 - 2.5 8.2 10.5 7.6 6.6 5.9 2.7 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_2 PF12756.7 EFE44499.1 - 3.4 8.1 11.1 2.5 8.5 1.4 3.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF3074 PF11274.8 EFE44500.1 - 0.0035 17.3 0.0 0.0059 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Stk19 PF10494.9 EFE44501.1 - 1.6e-70 237.6 0.0 2.3e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 DUF3074 PF11274.8 EFE44501.1 - 0.00036 20.6 0.2 0.0007 19.6 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Glyco_transf_20 PF00982.21 EFE44502.1 - 2.6e-157 524.3 0.6 3.7e-157 523.8 0.1 1.4 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EFE44502.1 - 1.8e-35 122.1 0.0 1.1e-34 119.7 0.0 2.1 1 1 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 EFE44502.1 - 0.03 14.0 1.1 0.076 12.7 0.4 1.9 2 0 0 2 2 2 0 Starch synthase catalytic domain Glyco_trans_1_4 PF13692.6 EFE44502.1 - 0.077 13.4 0.0 0.36 11.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferases group 1 Sporozoite_P67 PF05642.11 EFE44502.1 - 1.3 7.1 8.4 2.1 6.3 8.4 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen 4HBT_3 PF13622.6 EFE44503.1 - 1.8e-46 159.4 0.0 2.1e-46 159.2 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 EFE44504.1 - 4.1e-06 27.1 0.0 6.5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DUF29 PF01724.16 EFE44506.1 - 0.0094 16.2 0.2 0.012 15.8 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF29 CDT1_C PF16679.5 EFE44506.1 - 0.024 15.0 0.3 0.05 14.0 0.1 1.6 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain UME PF08064.13 EFE44506.1 - 0.047 13.6 0.1 0.16 11.9 0.0 1.9 2 1 0 2 2 2 0 UME (NUC010) domain Transglut_i_TM PF14400.6 EFE44506.1 - 0.11 12.6 2.0 1.5 8.9 2.7 2.0 1 1 1 2 2 2 0 Inactive transglutaminase fused to 7 transmembrane helices Peptidase_C65 PF10275.9 EFE44506.1 - 0.13 11.7 0.8 0.18 11.2 0.8 1.2 1 0 0 1 1 1 0 Peptidase C65 Otubain DUF883 PF05957.13 EFE44506.1 - 0.22 12.1 3.6 0.3 11.7 3.6 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) bZIP_2 PF07716.15 EFE44507.1 - 0.00015 21.8 9.7 0.00028 20.9 9.7 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EFE44507.1 - 0.0011 19.0 10.2 0.012 15.7 5.3 2.3 1 1 1 2 2 2 2 bZIP transcription factor Pox_A_type_inc PF04508.12 EFE44507.1 - 0.15 12.0 2.0 0.48 10.4 2.0 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat DBP10CT PF08147.12 EFE44508.1 - 0.11 12.8 0.2 0.21 11.9 0.2 1.5 1 0 0 1 1 1 0 DBP10CT (NUC160) domain WD40 PF00400.32 EFE44509.1 - 2.3e-31 107.4 18.0 4e-08 33.8 0.1 8.0 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE44509.1 - 3.1e-11 43.4 5.0 0.0091 16.3 0.2 4.9 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EFE44509.1 - 0.12 11.4 0.3 0.22 10.5 0.3 1.4 1 0 0 1 1 1 0 Coatomer WD associated region Yae1_N PF09811.9 EFE44510.1 - 3.7e-05 23.3 1.2 5.8e-05 22.7 1.2 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal tRNA-synt_1g PF09334.11 EFE44511.1 - 3.4e-149 496.9 0.0 5.2e-149 496.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EFE44511.1 - 6.9e-08 31.2 0.0 4.1e-05 22.0 0.0 3.6 2 2 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) Laminin_EGF PF00053.24 EFE44511.1 - 0.34 11.1 3.8 0.6 10.3 3.8 1.4 1 0 0 1 1 1 0 Laminin EGF domain PepSY PF03413.19 EFE44511.1 - 0.42 11.2 4.5 15 6.2 0.0 2.7 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain BRF1 PF07741.13 EFE44511.1 - 0.82 10.0 9.1 1.7 9.0 9.1 1.5 1 0 0 1 1 1 0 Brf1-like TBP-binding domain AP3D1 PF06375.11 EFE44511.1 - 1.3 9.3 9.3 2.1 8.6 9.3 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Elongin_A PF06881.11 EFE44511.1 - 4.8 7.8 8.4 4 8.0 5.9 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A WD40 PF00400.32 EFE44512.1 - 4.7e-18 65.2 5.8 0.002 18.9 0.0 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE44512.1 - 2.7e-07 30.8 0.0 0.019 15.2 0.0 4.5 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFE44512.1 - 0.0053 15.8 0.6 0.098 11.6 0.0 2.7 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFE44512.1 - 0.15 10.7 1.0 5.5 5.5 0.1 2.8 3 0 0 3 3 3 0 Nucleoporin Nup120/160 PXA PF02194.15 EFE44514.1 - 6.2e-46 156.7 0.2 4.1e-45 154.0 0.2 2.4 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EFE44514.1 - 1.1e-25 90.3 0.0 4.3e-25 88.5 0.0 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EFE44514.1 - 1.7e-19 69.8 0.1 6.5e-19 68.0 0.1 2.0 2 0 0 2 2 2 1 PX domain RGS PF00615.19 EFE44514.1 - 8e-11 42.2 0.0 2e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain Tcp11 PF05794.13 EFE44515.1 - 5.8e-106 355.2 0.2 5.8e-106 355.2 0.2 1.9 2 0 0 2 2 2 1 T-complex protein 11 HMA PF00403.26 EFE44516.1 - 0.0001 22.7 0.2 0.00013 22.4 0.2 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Vps4_C PF09336.10 EFE44516.1 - 0.0027 17.7 0.0 0.0031 17.5 0.0 1.1 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AHSP PF09236.10 EFE44516.1 - 0.12 12.9 0.0 0.15 12.5 0.0 1.1 1 0 0 1 1 1 0 Alpha-haemoglobin stabilising protein MHYT PF03707.16 EFE44517.1 - 2e-15 56.7 24.2 1.1e-09 38.3 1.1 4.4 4 1 0 4 4 4 2 Bacterial signalling protein N terminal repeat ESSS PF10183.9 EFE44519.1 - 0.19 12.0 1.8 0.2 11.9 0.0 1.9 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) TRAPPC9-Trs120 PF08626.11 EFE44519.1 - 1.4 6.2 3.2 1.8 5.8 3.2 1.0 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF2293 PF10056.9 EFE44520.1 - 0.00036 20.7 0.9 0.0014 18.8 0.0 2.5 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2293) Rep_fac-A_C PF08646.10 EFE44521.1 - 7.9e-42 142.4 8.9 2.1e-40 137.8 6.0 2.3 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EFE44521.1 - 3.4e-35 119.9 0.3 7.9e-35 118.7 0.1 1.7 2 0 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 EFE44521.1 - 7e-13 48.4 0.1 1e-07 31.8 0.0 3.8 3 1 1 4 4 4 3 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EFE44521.1 - 0.005 16.6 0.7 0.11 12.3 0.3 2.5 3 0 0 3 3 3 1 Cell division control protein 24, OB domain 3 Ribosomal_L37ae PF01780.19 EFE44521.1 - 0.025 14.7 0.5 0.051 13.7 0.5 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family DUF4503 PF14951.6 EFE44521.1 - 0.025 13.1 0.2 0.038 12.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) DUF223 PF02721.14 EFE44521.1 - 0.2 12.0 0.6 1.3 9.4 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF223 Tmp39 PF10271.9 EFE44522.1 - 0.098 11.6 0.0 0.12 11.4 0.0 1.0 1 0 0 1 1 1 0 Putative transmembrane protein La PF05383.17 EFE44523.1 - 2.1e-19 69.3 0.3 3.8e-19 68.5 0.3 1.4 1 0 0 1 1 1 1 La domain Ank_5 PF13857.6 EFE44524.1 - 8.9e-13 48.2 0.3 1.8e-10 40.9 0.3 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFE44524.1 - 5.4e-11 42.8 0.0 1.3e-07 32.0 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFE44524.1 - 7.8e-09 36.0 0.3 1.6e-08 35.0 0.1 1.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFE44524.1 - 9.9e-07 28.6 0.1 6e-05 23.1 0.2 2.9 2 1 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EFE44524.1 - 0.0011 19.4 0.0 0.016 15.7 0.2 2.5 2 0 0 2 2 2 1 Ankyrin repeat YejG PF13989.6 EFE44524.1 - 0.08 13.4 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 YejG-like protein T4BSS_DotH_IcmK PF12293.8 EFE44525.1 - 0.024 13.9 0.0 0.043 13.0 0.0 1.4 1 0 0 1 1 1 0 Putative outer membrane core complex of type IVb secretion NAT PF04768.13 EFE44526.1 - 4.3e-52 176.2 0.1 9.4e-52 175.1 0.0 1.6 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 EFE44526.1 - 9.5e-32 110.0 0.0 3.1e-31 108.3 0.0 2.0 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 EFE44526.1 - 7.9e-28 97.7 0.3 1.8e-27 96.5 0.0 1.7 2 0 0 2 2 2 1 Amino acid kinase family Synaptobrevin PF00957.21 EFE44527.1 - 2e-32 110.8 0.9 2.4e-32 110.5 0.9 1.0 1 0 0 1 1 1 1 Synaptobrevin AKNA PF12443.8 EFE44527.1 - 0.064 13.9 0.1 0.12 13.1 0.1 1.4 1 1 0 1 1 1 0 AT-hook-containing transcription factor Fzo_mitofusin PF04799.13 EFE44527.1 - 0.17 11.4 0.2 0.23 11.0 0.2 1.2 1 0 0 1 1 1 0 fzo-like conserved region DUF5421 PF17458.2 EFE44528.1 - 0.0046 16.4 2.6 0.0053 16.2 2.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5421) Pox_Ag35 PF03286.14 EFE44528.1 - 0.006 16.4 10.9 0.006 16.4 10.9 1.2 1 0 0 1 1 1 1 Pox virus Ag35 surface protein PBP1_TM PF14812.6 EFE44528.1 - 0.017 15.4 9.3 0.025 14.9 9.3 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Vfa1 PF08432.10 EFE44528.1 - 0.023 15.0 11.3 0.021 15.2 11.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DNA_pol_phi PF04931.13 EFE44528.1 - 0.026 12.6 6.8 0.027 12.6 6.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi DarA_C PF18789.1 EFE44528.1 - 0.034 14.4 0.6 0.053 13.8 0.4 1.4 1 1 0 1 1 1 0 Defence against restriction A C-terminal DUF4746 PF15928.5 EFE44528.1 - 0.097 12.1 10.2 0.1 12.0 10.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Dicty_REP PF05086.12 EFE44528.1 - 0.15 10.0 4.5 0.13 10.2 4.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SpoIIP PF07454.11 EFE44528.1 - 0.17 11.3 7.1 0.15 11.5 7.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAM60A PF15396.6 EFE44528.1 - 0.21 11.6 7.2 0.2 11.7 7.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF3464 PF11947.8 EFE44528.1 - 0.3 10.8 11.0 0.48 10.2 11.0 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Eapp_C PF10238.9 EFE44528.1 - 0.32 11.0 7.0 0.38 10.8 7.0 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein FancD2 PF14631.6 EFE44528.1 - 0.5 7.7 8.8 0.51 7.7 8.8 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RNA_polI_A34 PF08208.11 EFE44528.1 - 0.5 10.4 15.0 0.56 10.3 15.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 NPR3 PF03666.13 EFE44528.1 - 0.5 9.1 12.7 0.53 9.0 12.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AIF_C PF14721.6 EFE44528.1 - 0.56 10.6 6.4 0.71 10.2 6.4 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Zip PF02535.22 EFE44528.1 - 0.62 9.2 4.7 0.58 9.3 4.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Slu7 PF11708.8 EFE44528.1 - 0.63 9.7 15.1 0.68 9.6 15.1 1.0 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Serinc PF03348.15 EFE44528.1 - 0.9 8.4 3.3 0.9 8.4 3.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) CSRNP_N PF16019.5 EFE44528.1 - 1 9.2 9.7 1 9.2 9.7 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus TFB6 PF17110.5 EFE44528.1 - 1.1 9.0 9.0 1.3 8.7 9.0 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Connexin PF00029.19 EFE44528.1 - 1.1 9.0 8.2 1.1 8.9 8.2 1.1 1 0 0 1 1 1 0 Connexin DUF2828 PF11443.8 EFE44528.1 - 1.2 7.2 10.3 1.1 7.3 10.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CDC45 PF02724.14 EFE44528.1 - 1.2 7.3 10.2 1.1 7.4 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EFE44528.1 - 1.5 7.5 9.5 1.5 7.5 9.5 1.1 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 EFE44528.1 - 1.5 8.0 11.9 2.1 7.6 11.9 1.2 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 EFE44528.1 - 1.8 7.7 5.9 2.1 7.5 5.9 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SAPS PF04499.15 EFE44528.1 - 1.9 7.2 8.1 1.9 7.2 8.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2151 PF10221.9 EFE44528.1 - 2 6.9 8.5 1.8 7.1 8.5 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DUF3405 PF11885.8 EFE44528.1 - 2 6.9 8.0 2.4 6.7 8.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Rtf2 PF04641.12 EFE44528.1 - 2.1 7.6 15.0 2.5 7.4 15.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DDHD PF02862.17 EFE44528.1 - 2.5 8.2 6.1 2.3 8.3 6.1 1.1 1 0 0 1 1 1 0 DDHD domain RPOL_N PF14700.6 EFE44528.1 - 2.5 7.4 14.0 3 7.1 14.0 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal PPL5 PF18168.1 EFE44528.1 - 2.9 7.1 8.3 2.9 7.1 8.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 HSP90 PF00183.18 EFE44528.1 - 3.3 6.5 15.1 3.9 6.3 15.1 1.0 1 0 0 1 1 1 0 Hsp90 protein PIEZO PF15917.5 EFE44528.1 - 3.4 7.1 10.8 3.9 6.9 10.8 1.1 1 0 0 1 1 1 0 Piezo Afi1 PF07792.12 EFE44528.1 - 4 7.9 14.3 4.9 7.7 14.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF5427 PF10310.9 EFE44528.1 - 4.1 6.3 14.5 4.6 6.1 14.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CLN3 PF02487.17 EFE44528.1 - 4.1 6.3 4.8 4.5 6.2 4.8 1.0 1 0 0 1 1 1 0 CLN3 protein DUF913 PF06025.12 EFE44528.1 - 4.2 6.2 10.6 4.6 6.1 10.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NARP1 PF12569.8 EFE44528.1 - 5.2 5.9 14.8 5.2 5.8 14.8 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MCM_bind PF09739.9 EFE44528.1 - 5.4 5.3 13.6 5.9 5.2 13.6 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Tim54 PF11711.8 EFE44528.1 - 6 5.5 14.3 6.6 5.4 14.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2956 PF11169.8 EFE44528.1 - 7.2 6.9 14.1 12 6.1 14.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) OATP PF03137.20 EFE44528.1 - 7.4 4.7 4.4 6.6 4.9 4.4 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ALMT PF11744.8 EFE44528.1 - 7.6 5.2 6.3 7.1 5.3 6.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter TLP-20 PF06088.11 EFE44528.1 - 7.7 6.4 11.3 9.8 6.0 11.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DDRGK PF09756.9 EFE44528.1 - 9.6 5.7 24.5 12 5.5 24.5 1.1 1 0 0 1 1 1 0 DDRGK domain NUDIX_2 PF13869.6 EFE44530.1 - 2.3e-81 271.9 0.0 2.7e-81 271.7 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase SUKH-3 PF14433.6 EFE44530.1 - 0.15 12.6 0.0 0.46 11.0 0.0 1.9 1 1 0 1 1 1 0 SUKH-3 immunity protein CoaE PF01121.20 EFE44531.1 - 6.1e-42 143.3 0.0 8.3e-42 142.9 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EFE44531.1 - 0.016 15.8 0.1 0.09 13.3 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFE44531.1 - 0.089 13.0 0.0 0.75 9.9 0.0 2.3 1 1 0 1 1 1 0 AAA domain 2TM PF13239.6 EFE44531.1 - 0.12 12.7 0.1 0.12 12.7 0.1 1.6 2 0 0 2 2 2 0 2TM domain ECH_1 PF00378.20 EFE44533.1 - 5.4e-44 150.4 0.0 7.2e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFE44533.1 - 9.8e-22 77.9 0.0 1.6e-21 77.2 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase LPD15 PF18828.1 EFE44533.1 - 0.061 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent-protein-associated domain 15 APH PF01636.23 EFE44535.1 - 6.2e-22 78.7 0.0 9.1e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE44535.1 - 2.3e-06 27.3 0.0 3.1e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 EFE44535.1 - 0.0047 16.2 0.0 0.19 10.9 0.0 2.1 2 0 0 2 2 2 1 Fructosamine kinase RIO1 PF01163.22 EFE44535.1 - 0.0063 16.1 0.0 0.071 12.7 0.0 2.1 2 0 0 2 2 2 1 RIO1 family DUF1679 PF07914.11 EFE44535.1 - 0.019 13.9 0.0 0.033 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) EcKinase PF02958.20 EFE44535.1 - 0.024 14.0 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Pkinase PF00069.25 EFE44535.1 - 0.053 12.9 0.0 0.16 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain FMO-like PF00743.19 EFE44536.1 - 3.1e-18 65.5 0.4 3.9e-16 58.6 0.1 2.8 2 1 1 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EFE44536.1 - 1.5e-05 24.3 0.0 0.0051 16.1 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFE44536.1 - 0.00021 20.5 0.0 0.0023 17.1 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFE44536.1 - 0.0006 20.0 0.3 0.0022 18.2 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFE44536.1 - 0.0025 17.1 0.2 0.12 11.7 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFE44536.1 - 0.16 12.0 0.0 5.6 6.9 0.0 3.0 3 1 0 3 3 3 0 FAD-NAD(P)-binding GCR1_C PF12550.8 EFE44536.1 - 0.21 11.9 1.6 2.3 8.6 0.0 2.8 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes PQQ_3 PF13570.6 EFE44537.1 - 0.2 12.2 3.1 12 6.5 0.1 3.7 3 0 0 3 3 3 0 PQQ-like domain DUF1668 PF07893.13 EFE44537.1 - 8.5 5.6 9.4 0.14 11.5 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1668) ERG4_ERG24 PF01222.17 EFE44538.1 - 2.7e-145 484.4 9.9 3.3e-145 484.2 9.9 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EFE44538.1 - 6.6e-05 22.5 0.8 0.00014 21.4 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) Proteasome PF00227.26 EFE44539.1 - 3.5e-39 134.3 0.1 1.3e-38 132.4 0.1 1.7 1 1 0 1 1 1 1 Proteasome subunit Terminase_5 PF06056.12 EFE44539.1 - 0.049 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Aldo_ket_red PF00248.21 EFE44540.1 - 4.6e-38 131.1 0.0 1.7e-36 125.9 0.0 2.7 1 1 0 1 1 1 1 Aldo/keto reductase family APH PF01636.23 EFE44540.1 - 1.4e-10 41.5 0.0 3.9e-10 40.1 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family FAD-oxidase_C PF02913.19 EFE44541.1 - 5.4e-56 190.0 0.0 8.6e-56 189.4 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFE44541.1 - 1e-35 122.5 0.4 2e-35 121.5 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain Pkinase PF00069.25 EFE44542.1 - 1.4e-70 237.7 0.0 1.9e-70 237.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44542.1 - 6.8e-48 163.2 0.0 1e-47 162.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE44542.1 - 1.2e-05 24.4 0.0 3.4e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFE44542.1 - 0.00018 21.0 0.0 0.0032 16.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFE44542.1 - 0.035 14.0 0.1 6.5 6.6 0.0 2.8 3 1 1 4 4 4 0 Phosphotransferase enzyme family ABC1 PF03109.16 EFE44542.1 - 0.17 12.0 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 ABC1 family RicinB_lectin_2 PF14200.6 EFE44543.1 - 0.13 13.0 0.0 4.8 8.0 0.0 2.2 1 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Ribosomal_L9_N PF01281.19 EFE44544.1 - 0.18 11.4 0.0 0.39 10.3 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L9, N-terminal domain UPF0262 PF06793.12 EFE44545.1 - 0.018 15.2 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0262) Prim-Pol PF09250.11 EFE44545.1 - 0.041 14.2 0.1 0.056 13.8 0.1 1.2 1 0 0 1 1 1 0 Bifunctional DNA primase/polymerase, N-terminal CAP59_mtransfer PF11735.8 EFE44546.1 - 1.3e-62 211.7 1.2 2.5e-47 161.6 0.3 2.1 1 1 1 2 2 2 2 Cryptococcal mannosyltransferase 1 Herpes_UL37_2 PF07413.11 EFE44546.1 - 0.063 12.5 0.0 0.098 11.9 0.0 1.2 1 0 0 1 1 1 0 Betaherpesvirus immediate-early glycoprotein UL37 DUF4048 PF13257.6 EFE44547.1 - 3.3e-80 269.6 21.6 3.3e-80 269.6 21.6 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4048) SLATT_1 PF18181.1 EFE44547.1 - 0.054 13.4 0.5 0.099 12.6 0.5 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Bap31_Bap29_C PF18035.1 EFE44547.1 - 0.16 12.0 3.2 0.32 11.0 3.2 1.4 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain GREB1 PF15782.5 EFE44547.1 - 6.2 3.8 8.5 9 3.3 8.5 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Tim17 PF02466.19 EFE44548.1 - 2.7e-37 127.5 5.9 3.1e-37 127.3 5.9 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Romo1 PF10247.9 EFE44548.1 - 6.3 7.2 13.2 5.2 7.5 1.8 3.2 2 1 1 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 Oxidored_molyb PF00174.19 EFE44549.1 - 1.8e-59 200.2 0.0 2.7e-59 199.6 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EFE44549.1 - 3.5e-26 91.9 0.9 7.3e-26 90.8 0.9 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain PALP PF00291.25 EFE44550.1 - 2.7e-57 194.4 0.7 3.5e-57 194.1 0.7 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cnd3 PF12719.7 EFE44551.1 - 1.1e-90 303.9 0.1 1.7e-89 300.0 0.0 2.5 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EFE44551.1 - 4.4e-09 36.6 4.5 6e-05 23.3 0.3 4.3 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 EFE44551.1 - 5.5e-07 30.0 2.6 0.39 11.3 0.1 5.4 4 1 1 5 5 5 3 HEAT-like repeat HEAT PF02985.22 EFE44551.1 - 7.5e-06 25.8 6.7 0.24 11.8 0.0 6.5 7 0 0 7 7 7 2 HEAT repeat Cnd1 PF12717.7 EFE44551.1 - 0.0028 17.7 0.1 0.11 12.6 0.0 3.4 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RICTOR_N PF14664.6 EFE44551.1 - 0.034 13.1 0.7 1.7 7.5 0.1 2.8 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term MMS19_N PF14500.6 EFE44551.1 - 0.044 13.3 0.1 1.4 8.4 0.0 3.0 3 1 1 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF3306 PF11748.8 EFE44551.1 - 0.41 11.5 0.0 0.41 11.5 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3306) zf-RanBP PF00641.18 EFE44552.1 - 1.4e-19 69.1 8.4 5.8e-10 38.3 1.5 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EFE44552.1 - 6.5e-07 29.1 0.0 1.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fungal_trans PF04082.18 EFE44553.1 - 1.5e-17 63.5 1.3 4e-17 62.1 1.3 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE44553.1 - 6.5e-06 26.2 8.2 1.3e-05 25.3 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SNase PF00565.17 EFE44555.1 - 2.9e-80 265.8 0.2 6.9e-26 90.8 0.0 5.4 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EFE44555.1 - 1.2e-24 86.6 0.0 3.5e-24 85.2 0.0 1.7 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 EFE44555.1 - 0.00024 20.4 0.0 0.00044 19.6 0.0 1.3 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Agenet PF05641.12 EFE44555.1 - 0.0088 16.5 0.9 0.048 14.1 0.2 2.7 3 0 0 3 3 3 1 Agenet domain DUF3297 PF11730.8 EFE44555.1 - 0.032 14.1 0.0 0.14 12.0 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) CRAL_TRIO PF00650.20 EFE44556.1 - 3.1e-24 85.5 0.0 4.6e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFE44556.1 - 5.3e-08 32.9 0.0 1.8e-07 31.2 0.0 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain HMG-CoA_red PF00368.18 EFE44557.1 - 5.2e-135 450.2 6.8 7.3e-135 449.7 6.8 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 EFE44557.1 - 2.2e-11 43.8 6.6 2.2e-11 43.8 6.6 2.6 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation HPIH PF13323.6 EFE44557.1 - 3.1e-11 43.3 0.1 5.9e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Patched PF02460.18 EFE44557.1 - 8.3e-06 24.2 1.8 1.3e-05 23.5 1.8 1.2 1 0 0 1 1 1 1 Patched family DUF3328 PF11807.8 EFE44557.1 - 3.1 7.5 3.6 3 7.6 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3328) CVNH PF08881.10 EFE44558.1 - 1.6e-25 89.7 0.5 2e-25 89.4 0.5 1.1 1 0 0 1 1 1 1 CVNH domain PBP1_TM PF14812.6 EFE44559.1 - 0.0012 19.2 3.2 0.002 18.4 3.2 1.4 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal GIT_SHD PF08518.11 EFE44560.1 - 4.5e-22 77.4 10.1 2e-11 43.3 1.2 2.8 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT TPR_MLP1_2 PF07926.12 EFE44560.1 - 0.0035 17.4 14.7 0.0035 17.4 14.7 4.1 5 1 0 5 5 5 1 TPR/MLP1/MLP2-like protein EzrA PF06160.12 EFE44560.1 - 0.016 13.4 25.7 0.044 12.0 14.6 2.7 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Piezo_RRas_bdg PF12166.8 EFE44560.1 - 0.017 14.4 1.4 0.035 13.4 1.4 1.4 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain Phage_Nu1 PF07471.12 EFE44560.1 - 2.7 7.7 11.4 0.093 12.5 0.8 3.0 1 1 2 3 3 3 0 Phage DNA packaging protein Nu1 Pro_isomerase PF00160.21 EFE44561.1 - 1.3e-41 142.5 0.1 2.1e-41 141.9 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RNase_PH PF01138.21 EFE44562.1 - 2e-33 115.7 0.6 4.7e-33 114.5 0.2 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 SNF2_N PF00176.23 EFE44563.1 - 2.9e-53 180.8 0.0 4.6e-53 180.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 EFE44563.1 - 7.5e-25 86.8 0.1 1.8e-24 85.6 0.1 1.7 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 EFE44563.1 - 3e-19 69.4 0.0 1.1e-18 67.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EFE44563.1 - 1.9e-08 33.8 0.0 3.7e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EFE44563.1 - 7.1e-08 32.6 0.2 3e-07 30.6 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Ssu72 PF04722.13 EFE44564.1 - 3.8e-82 274.5 0.0 4.4e-82 274.3 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein PRIMA1 PF16101.5 EFE44564.1 - 0.85 9.7 9.3 1.5 8.9 9.3 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 EFE44564.1 - 1.8 8.6 4.8 2.5 8.1 4.8 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator VIR_N PF15912.5 EFE44564.1 - 6.8 6.2 8.1 9.8 5.7 8.1 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal zf-CHCC PF10276.9 EFE44565.1 - 0.0034 17.4 3.9 0.059 13.4 0.3 2.8 2 0 0 2 2 2 1 Zinc-finger domain zf-CCHC PF00098.23 EFE44565.1 - 0.053 13.6 3.3 0.1 12.7 3.3 1.5 1 0 0 1 1 1 0 Zinc knuckle PyrI_C PF02748.15 EFE44565.1 - 0.12 12.3 0.6 18 5.3 0.1 2.5 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 EFE44565.1 - 0.68 10.0 3.9 12 6.0 0.1 2.5 2 0 0 2 2 2 0 BED zinc finger Acyl-CoA_dh_1 PF00441.24 EFE44566.1 - 4.9e-18 65.8 0.1 2.7e-17 63.4 0.1 2.2 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFE44566.1 - 4.6e-10 39.6 0.0 1.7e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain AidB_N PF18158.1 EFE44566.1 - 2.9e-08 33.8 0.0 5.4e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Oxysterol_BP PF01237.18 EFE44567.1 - 5.3e-70 236.1 0.2 2.4e-67 227.4 0.2 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein p450 PF00067.22 EFE44568.1 - 1.1e-21 77.2 0.0 1.3e-21 77.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EFE44569.1 - 3.2e-55 187.7 0.0 7.5e-53 179.9 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 DUF1788 PF08747.11 EFE44569.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1788) adh_short PF00106.25 EFE44571.1 - 1.9e-26 92.7 0.0 1.5e-24 86.5 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE44571.1 - 7.8e-15 55.1 0.0 9.5e-14 51.5 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE44571.1 - 4.7e-05 23.4 0.0 7.6e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EFE44571.1 - 0.0066 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 EFE44571.1 - 0.012 15.1 0.0 0.018 14.5 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Csm1_B PF18211.1 EFE44571.1 - 0.034 14.0 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 Csm1 subunit domain B SLD5_C PF16922.5 EFE44571.1 - 0.21 11.8 0.0 0.47 10.7 0.0 1.6 1 0 0 1 1 1 0 DNA replication complex GINS protein SLD5 C-terminus Polysacc_synt_2 PF02719.15 EFE44571.1 - 0.21 10.7 0.0 0.27 10.3 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EFE44571.1 - 0.23 10.8 0.0 0.31 10.4 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase CtIP_N PF10482.9 EFE44573.1 - 0.022 14.8 1.4 0.039 14.0 1.4 1.4 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Plasmodium_Vir PF05795.11 EFE44573.1 - 0.035 13.5 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF2408 PF10303.9 EFE44573.1 - 0.049 14.2 0.3 0.087 13.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Hat1_N PF10394.9 EFE44574.1 - 1.2e-48 165.4 0.2 2.6e-48 164.3 0.2 1.6 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus DUF917 PF06032.12 EFE44575.1 - 3.1e-123 411.1 0.2 4e-122 407.4 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 EFE44575.1 - 1.6e-25 90.0 6.4 1.6e-23 83.4 3.2 2.3 1 1 1 2 2 2 2 Hydantoinase/oxoprolinase StbA PF06406.11 EFE44575.1 - 0.2 10.9 2.5 14 4.8 2.5 2.3 1 1 0 1 1 1 0 StbA protein Hydant_A_N PF05378.13 EFE44575.1 - 2.9 7.6 6.0 8.8 6.0 0.1 2.9 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase N-terminal region Transp_cyt_pur PF02133.15 EFE44577.1 - 2.5e-99 333.1 37.1 2.9e-99 332.8 37.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Zip PF02535.22 EFE44578.1 - 7.5e-32 110.9 18.1 6.9e-23 81.4 12.6 3.1 2 1 1 3 3 3 3 ZIP Zinc transporter WD40 PF00400.32 EFE44579.1 - 4e-36 122.4 21.4 1.7e-06 28.6 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 EFE44579.1 - 1.7e-10 40.6 0.6 3.1e-10 39.8 0.6 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EFE44579.1 - 2.9e-10 40.3 1.0 0.1 12.9 0.0 6.1 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE44579.1 - 2.3e-07 29.8 3.5 0.063 11.9 0.1 5.3 2 2 3 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 EFE44579.1 - 6e-06 25.8 0.0 0.0042 16.5 0.0 3.3 1 1 3 4 4 4 1 WD40-like domain F-box PF00646.33 EFE44579.1 - 0.00064 19.5 0.6 0.0015 18.4 0.6 1.7 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.6 EFE44579.1 - 0.0098 15.5 1.4 0.082 12.5 0.5 2.5 1 1 1 2 2 2 1 PQQ-like domain F-box_5 PF18511.1 EFE44579.1 - 0.052 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 F-box DUF3245 PF11595.8 EFE44580.1 - 0.18 12.3 2.1 0.2 12.1 2.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Sugar_tr PF00083.24 EFE44583.1 - 2.4e-87 293.7 22.9 2.4e-87 293.7 22.9 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFE44583.1 - 1.4e-10 40.6 48.8 7e-06 25.2 21.3 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily VIT1 PF01988.19 EFE44583.1 - 0.25 11.2 0.0 0.25 11.2 0.0 3.6 3 2 0 3 3 3 0 VIT family Peptidase_S64 PF08192.11 EFE44584.1 - 9.8e-07 27.7 0.0 1.7e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S64 Trypsin PF00089.26 EFE44584.1 - 0.027 14.3 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Trypsin YtxH PF12732.7 EFE44586.1 - 0.9 10.1 9.1 0.58 10.7 7.0 1.7 1 1 1 2 2 2 0 YtxH-like protein Alanine_zipper PF11839.8 EFE44586.1 - 2.9 8.3 19.0 7.8 7.0 19.0 1.8 1 1 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein FHA PF00498.26 EFE44587.1 - 9.3e-13 48.3 0.0 1.6e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFE44587.1 - 0.018 15.3 0.0 0.75 10.2 0.0 2.2 1 1 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain MFS_1 PF07690.16 EFE44588.1 - 6.4e-33 114.1 47.1 3.9e-31 108.3 28.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans_2 PF11951.8 EFE44589.1 - 5.8e-12 45.1 3.8 6.8e-12 44.9 3.8 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DnaJ PF00226.31 EFE44590.1 - 2.8e-08 33.7 0.1 5.7e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain SUKH-4 PF14435.6 EFE44590.1 - 0.087 12.9 0.3 1.2 9.2 0.1 2.1 2 0 0 2 2 2 0 SUKH-4 immunity protein Abhydrolase_3 PF07859.13 EFE44591.1 - 8.7e-26 91.1 0.0 1.4e-24 87.2 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFE44591.1 - 0.0011 17.9 0.5 0.014 14.2 0.1 2.6 2 1 0 2 2 2 1 Steryl acetyl hydrolase M_domain PF12938.7 EFE44594.1 - 0.018 14.8 13.6 0.035 13.9 13.6 1.4 1 0 0 1 1 1 0 M domain of GW182 F-box-like PF12937.7 EFE44597.1 - 5.3e-05 23.0 0.0 0.00011 22.0 0.0 1.6 1 0 0 1 1 1 1 F-box-like DUF713 PF05218.14 EFE44598.1 - 0.05 13.3 8.9 0.034 13.9 3.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF713) Mucin PF01456.17 EFE44598.1 - 0.58 10.1 17.9 0.94 9.5 17.9 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein LMP PF04778.12 EFE44598.1 - 1.4 8.8 7.2 2.6 8.0 7.2 1.4 1 0 0 1 1 1 0 LMP repeated region NPR2 PF06218.11 EFE44599.1 - 4.7e-104 348.6 0.0 3.8e-103 345.6 0.0 2.2 1 1 0 1 1 1 1 Nitrogen permease regulator 2 Rox3 PF08633.10 EFE44599.1 - 0.27 11.5 2.0 1.3 9.3 1.8 1.9 2 0 0 2 2 2 0 Rox3 mediator complex subunit Ada3 PF10198.9 EFE44600.1 - 4.5e-50 169.2 1.8 5.6e-50 168.9 0.0 2.0 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 DUF572 PF04502.13 EFE44600.1 - 0.0077 15.9 1.4 0.014 15.0 1.4 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF572) zf-RING_2 PF13639.6 EFE44601.1 - 2.6e-10 40.4 8.0 2.6e-10 40.4 8.0 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 EFE44601.1 - 8.9e-08 31.8 1.1 8.9e-08 31.8 1.1 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFE44601.1 - 2.5e-07 30.4 4.8 4.7e-07 29.6 4.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFE44601.1 - 3.6e-06 26.7 3.4 6.9e-06 25.8 3.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE44601.1 - 1.9e-05 24.5 2.9 3.5e-05 23.7 2.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFE44601.1 - 8.6e-05 22.5 2.2 8.6e-05 22.5 2.2 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 EFE44601.1 - 0.0012 19.0 6.9 0.0048 17.1 6.9 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFE44601.1 - 0.0092 15.8 5.1 0.018 14.9 5.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFE44601.1 - 0.021 14.8 1.9 0.047 13.7 1.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger LapA_dom PF06305.11 EFE44601.1 - 0.12 12.2 2.3 0.28 11.0 2.3 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Prok-RING_4 PF14447.6 EFE44601.1 - 0.18 11.7 10.6 0.33 10.8 8.2 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFE44601.1 - 0.9 9.8 5.9 1.8 8.8 5.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FRG1 PF06229.12 EFE44602.1 - 7.1e-41 140.0 0.4 2.6e-40 138.2 0.4 1.8 1 1 0 1 1 1 1 FRG1-like domain ADH_N PF08240.12 EFE44603.1 - 4.2e-35 119.9 3.8 6.1e-35 119.4 2.8 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFE44603.1 - 2.7e-16 59.7 0.0 4.4e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFE44603.1 - 6.7e-12 45.3 0.0 1e-11 44.8 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EFE44603.1 - 4.5e-06 27.8 0.0 7.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 EFE44603.1 - 0.0069 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 EFE44603.1 - 0.012 16.1 0.0 0.022 15.2 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EFE44603.1 - 0.046 13.0 1.0 0.069 12.4 1.0 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_3 PF03447.16 EFE44603.1 - 0.11 13.1 0.0 1.1 10.0 0.0 2.3 2 1 1 3 3 3 0 Homoserine dehydrogenase, NAD binding domain NADH_4Fe-4S PF10589.9 EFE44603.1 - 1.1 9.4 3.6 0.38 10.9 0.4 2.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region HECT PF00632.25 EFE44604.1 - 1.9e-65 221.4 0.0 2.5e-65 221.0 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ribosomal_L15e PF00827.17 EFE44605.1 - 8.5e-83 276.8 15.9 1.1e-81 273.1 15.9 1.9 1 1 0 1 1 1 1 Ribosomal L15 T3SSipB PF16535.5 EFE44606.1 - 0.0061 17.0 1.7 0.0061 17.0 1.7 1.7 1 1 1 2 2 2 1 Type III cell invasion protein SipB AAA_assoc_2 PF16193.5 EFE44606.1 - 0.11 12.9 0.1 0.25 11.7 0.1 1.6 1 0 0 1 1 1 0 AAA C-terminal domain DBR1 PF05011.13 EFE44607.1 - 4.8e-43 146.9 0.1 5.4e-42 143.5 0.0 2.3 1 1 1 2 2 2 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EFE44607.1 - 2.7e-05 24.8 2.0 4.7e-05 24.0 2.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GRP PF07172.11 EFE44607.1 - 0.27 12.0 13.8 0.74 10.5 13.8 1.8 1 0 0 1 1 1 0 Glycine rich protein family RTP1_C1 PF10363.9 EFE44608.1 - 6.6e-30 103.6 0.1 6.5e-29 100.4 0.0 2.8 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EFE44608.1 - 5.8e-11 41.9 0.0 1.3e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 Lig_chan-Glu_bd PF10613.9 EFE44608.1 - 0.1 12.8 0.1 2.6 8.3 0.0 2.5 2 0 0 2 2 2 0 Ligated ion channel L-glutamate- and glycine-binding site Polysacc_deac_1 PF01522.21 EFE44609.1 - 1.5e-28 99.2 0.0 2.6e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EFE44609.1 - 8.5e-10 38.9 39.0 1.4e-05 25.5 16.2 2.5 2 0 0 2 2 2 2 Chitin recognition protein DUF2334 PF10096.9 EFE44609.1 - 0.059 13.0 0.0 0.091 12.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) CENP-U PF13097.6 EFE44610.1 - 0.033 14.1 1.3 0.033 14.1 1.3 2.3 2 1 1 3 3 3 0 CENP-A nucleosome associated complex (NAC) subunit RAD51_interact PF15696.5 EFE44610.1 - 0.037 14.1 0.1 0.11 12.6 0.1 1.8 1 0 0 1 1 1 0 RAD51 interacting motif FAD_binding_3 PF01494.19 EFE44611.1 - 4.5e-23 82.1 0.0 5.8e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFE44611.1 - 3.2e-06 26.6 0.8 0.00083 18.7 0.1 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFE44611.1 - 7.3e-05 23.2 0.2 0.00065 20.2 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFE44611.1 - 0.0017 18.0 1.8 0.0048 16.5 0.8 2.0 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFE44611.1 - 0.0031 16.7 0.9 0.0053 15.9 0.9 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFE44611.1 - 0.0058 16.8 0.4 0.013 15.7 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 EFE44611.1 - 0.024 13.7 0.0 0.043 12.9 0.0 1.4 1 1 0 1 1 1 0 Squalene epoxidase Trp_halogenase PF04820.14 EFE44611.1 - 0.033 13.0 0.1 5.2 5.8 0.0 2.8 3 0 0 3 3 3 0 Tryptophan halogenase 3HCDH_N PF02737.18 EFE44611.1 - 0.16 11.8 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EFE44611.1 - 0.32 10.0 0.8 0.48 9.4 0.8 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trypsin_2 PF13365.6 EFE44612.1 - 2e-05 25.6 0.0 5.8e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S7 PF00949.21 EFE44612.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.9 EFE44612.1 - 0.13 10.9 0.0 0.23 10.1 0.0 1.3 1 0 0 1 1 1 0 Peptidase S46 Clathrin PF00637.20 EFE44613.1 - 2.1e-20 73.1 3.0 9.9e-18 64.4 0.9 2.8 2 0 0 2 2 2 2 Region in Clathrin and VPS VPS11_C PF12451.8 EFE44613.1 - 2.4e-17 62.9 0.5 2.4e-17 62.9 0.5 2.0 2 0 0 2 2 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 EFE44613.1 - 5.4e-07 29.5 8.1 9.8e-07 28.7 8.1 1.5 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 EFE44613.1 - 4.4e-06 26.4 6.4 8.8e-06 25.5 6.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFE44613.1 - 0.0002 21.3 5.7 0.00043 20.2 5.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFE44613.1 - 0.00045 20.5 6.4 0.00089 19.5 6.4 1.5 1 0 0 1 1 1 1 Ring finger domain TPR_11 PF13414.6 EFE44613.1 - 0.00065 19.3 0.1 0.0023 17.6 0.1 2.0 1 0 0 1 1 1 1 TPR repeat zf-rbx1 PF12678.7 EFE44613.1 - 0.0079 16.5 4.7 0.016 15.5 4.7 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain TPR_14 PF13428.6 EFE44613.1 - 0.0083 16.9 0.1 0.33 11.9 0.0 3.5 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFE44613.1 - 0.029 14.6 0.1 1.3 9.4 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-C3HC4 PF00097.25 EFE44613.1 - 0.056 13.3 5.5 0.11 12.4 5.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.6 EFE44613.1 - 0.089 13.1 1.1 1.3 9.3 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFE44613.1 - 0.097 12.8 0.6 0.73 10.1 0.1 2.8 2 0 0 2 2 1 0 Tetratricopeptide repeat zf-ANAPC11 PF12861.7 EFE44613.1 - 0.54 10.3 2.3 1.6 8.9 2.3 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EFE44613.1 - 0.99 9.5 6.2 2.5 8.2 6.2 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFE44613.1 - 4.3 7.3 5.0 8.2 6.4 5.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) adh_short_C2 PF13561.6 EFE44614.1 - 6.6e-62 209.1 0.2 7.6e-62 208.9 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE44614.1 - 3.3e-42 144.2 0.3 3.9e-42 143.9 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE44614.1 - 1.8e-14 54.1 0.1 2.6e-14 53.6 0.1 1.2 1 0 0 1 1 1 1 KR domain zf-ZPR1 PF03367.13 EFE44615.1 - 9.8e-107 353.8 0.1 2.3e-54 183.6 0.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 EFE44615.1 - 0.019 15.0 1.2 1 9.4 0.1 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 EFE44615.1 - 0.042 13.8 2.1 1.8 8.6 0.2 2.6 2 1 0 2 2 2 0 zinc-ribbons OrfB_Zn_ribbon PF07282.11 EFE44615.1 - 0.14 12.1 0.1 9.5 6.2 0.0 2.6 2 0 0 2 2 2 0 Putative transposase DNA-binding domain zf-ISL3 PF14690.6 EFE44615.1 - 0.22 12.2 6.2 20 6.0 0.0 3.4 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn_Tnp_IS1595 PF12760.7 EFE44615.1 - 1.7 8.7 0.0 1.7 8.7 0.0 3.2 2 1 1 3 3 3 0 Transposase zinc-ribbon domain UPF0547 PF10571.9 EFE44615.1 - 7.1 6.8 15.6 2.4 8.3 1.0 3.3 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 Pro_isomerase PF00160.21 EFE44616.1 - 9.5e-15 55.2 0.0 1.7e-14 54.4 0.0 1.5 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Arrestin_C PF02752.22 EFE44617.1 - 1.1e-12 48.6 0.0 2.2e-12 47.6 0.0 1.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain tRNA_int_end_N2 PF12928.7 EFE44618.1 - 8.3e-29 99.6 0.0 1.4e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 EFE44618.1 - 0.005 16.5 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain Pkinase PF00069.25 EFE44619.1 - 6.8e-07 28.9 0.0 2e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFE44619.1 - 1.1e-06 28.8 1.6 1.9e-05 24.7 0.0 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFE44619.1 - 9.4e-05 21.8 0.0 0.00025 20.5 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFE44619.1 - 0.0019 17.9 0.1 0.032 13.8 0.0 2.5 3 0 0 3 3 3 1 Choline/ethanolamine kinase HSDR_N_2 PF13588.6 EFE44619.1 - 0.0049 16.9 0.1 4.4 7.3 0.0 3.4 3 0 0 3 3 3 1 Type I restriction enzyme R protein N terminus (HSDR_N) SR-25 PF10500.9 EFE44619.1 - 0.35 10.5 15.6 0.022 14.3 8.1 2.4 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein adh_short_C2 PF13561.6 EFE44620.1 - 4.2e-32 111.6 3.0 4.2e-30 105.0 3.0 2.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE44620.1 - 8.9e-31 106.9 4.5 3e-16 59.4 0.2 3.0 2 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EFE44620.1 - 4.8e-07 29.9 2.4 1.1e-06 28.7 0.2 2.4 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EFE44620.1 - 7.7e-06 25.5 0.0 1.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFE44620.1 - 0.0029 16.8 0.0 0.0059 15.8 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EFE44620.1 - 0.028 13.6 0.0 0.044 12.9 0.0 1.4 1 0 0 1 1 1 0 Male sterility protein ThiF PF00899.21 EFE44621.1 - 1.4e-73 247.3 0.0 2e-73 246.8 0.0 1.1 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EFE44621.1 - 9.3e-22 77.4 0.1 2.4e-21 76.1 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EFE44621.1 - 4.4e-08 33.4 0.8 0.0013 18.7 0.1 2.4 1 1 0 2 2 2 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 EFE44621.1 - 7.5e-05 23.1 0.0 0.0003 21.2 0.0 2.1 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EFE44621.1 - 0.021 14.9 0.0 0.046 13.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EFE44621.1 - 0.049 14.2 0.0 7.2 7.2 0.0 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase E2_bind PF08825.10 EFE44621.1 - 0.13 12.4 0.7 0.27 11.4 0.2 1.8 2 0 0 2 2 2 0 E2 binding domain Q_salvage PF10343.9 EFE44622.1 - 9.5e-134 445.3 0.1 1.1e-133 445.1 0.1 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family ORC6 PF05460.13 EFE44623.1 - 4.2e-34 118.4 0.1 9.5e-34 117.2 0.1 1.6 1 1 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Senescence_reg PF04520.13 EFE44623.1 - 0.01 16.7 2.6 0.11 13.3 0.3 2.3 2 0 0 2 2 2 0 Senescence regulator Amidase PF01425.21 EFE44624.1 - 2.2e-83 280.7 0.0 3.1e-83 280.2 0.0 1.2 1 0 0 1 1 1 1 Amidase DNA_pol_delta_4 PF04081.13 EFE44625.1 - 4.3e-15 56.2 15.2 3.5e-14 53.3 15.2 2.7 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 TFIIA PF03153.13 EFE44625.1 - 1.3 8.9 14.7 1.7 8.6 14.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit APH PF01636.23 EFE44628.1 - 2.3e-15 57.2 0.0 3.4e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE44628.1 - 0.0092 15.6 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase CRC_subunit PF08624.10 EFE44629.1 - 1.4e-51 174.5 0.2 2.2e-51 173.8 0.2 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit CAP_GLY PF01302.25 EFE44630.1 - 1.7e-15 56.8 0.5 4.4e-15 55.4 0.2 1.8 2 0 0 2 2 2 1 CAP-Gly domain CLIP1_ZNF PF16641.5 EFE44630.1 - 1.7e-07 30.9 9.6 4.9e-05 23.1 0.9 2.6 2 0 0 2 2 2 2 CLIP1 zinc knuckle Fez1 PF06818.15 EFE44630.1 - 0.00046 20.7 21.3 0.053 14.0 13.9 3.0 2 1 1 3 3 3 2 Fez1 TolA_bind_tri PF16331.5 EFE44630.1 - 0.011 15.8 2.5 0.011 15.8 2.5 4.0 2 1 0 3 3 3 0 TolA binding protein trimerisation Spc7 PF08317.11 EFE44630.1 - 0.017 14.0 23.8 0.12 11.3 12.3 3.0 2 1 1 3 3 3 0 Spc7 kinetochore protein AAA_13 PF13166.6 EFE44630.1 - 0.14 10.8 12.3 0.19 10.3 6.9 2.3 2 0 0 2 2 2 0 AAA domain DUF1664 PF07889.12 EFE44630.1 - 0.15 12.1 14.2 0.33 11.0 2.1 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF812 PF05667.11 EFE44630.1 - 0.16 10.9 22.0 0.073 12.0 13.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF812) C1_2 PF03107.16 EFE44630.1 - 0.23 11.8 2.0 9 6.7 0.1 2.4 2 0 0 2 2 2 0 C1 domain HMMR_N PF15905.5 EFE44630.1 - 0.5 9.8 24.7 3 7.2 0.4 2.6 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Sec34 PF04136.15 EFE44630.1 - 0.7 9.8 7.8 1.6 8.6 2.9 2.3 2 0 0 2 2 2 0 Sec34-like family EzrA PF06160.12 EFE44630.1 - 0.86 7.7 16.9 0.53 8.4 3.0 3.0 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA GIT_CC PF16559.5 EFE44630.1 - 1.1 9.2 5.7 16 5.5 2.0 2.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF745 PF05335.13 EFE44630.1 - 1.9 8.2 12.6 0.18 11.5 2.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF745) FAM76 PF16046.5 EFE44630.1 - 1.9 7.7 13.7 7.4 5.8 5.6 2.7 2 1 0 2 2 2 0 FAM76 protein PKcGMP_CC PF16808.5 EFE44630.1 - 3.5 7.6 27.3 0.23 11.4 2.1 4.6 5 0 0 5 5 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF16 PF01519.16 EFE44630.1 - 4.5 7.8 13.0 3.5 8.2 0.1 4.0 3 1 1 4 4 4 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 EFE44630.1 - 7.9 7.0 14.0 53 4.4 0.1 4.3 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Pkinase PF00069.25 EFE44631.1 - 1.6e-34 119.5 0.0 1.4e-19 70.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44631.1 - 2e-11 43.7 0.0 7.3e-09 35.3 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFE44631.1 - 0.0055 16.1 0.0 0.63 9.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EFE44631.1 - 0.009 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF3632 PF12311.8 EFE44632.1 - 7.3e-08 33.1 0.0 9.1e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) OPT PF03169.15 EFE44633.1 - 3.6e-68 230.7 44.7 1.2e-62 212.4 38.6 2.0 1 1 1 2 2 2 2 OPT oligopeptide transporter protein PWWP PF00855.17 EFE44634.1 - 1.6e-14 54.1 8.1 1.6e-14 54.1 8.1 3.7 2 1 0 2 2 2 1 PWWP domain ComA PF02679.15 EFE44635.1 - 1.3e-26 93.5 0.0 6e-19 68.5 0.0 2.1 1 1 1 2 2 2 2 (2R)-phospho-3-sulfolactate synthase (ComA) SpoIIE PF07228.12 EFE44636.1 - 2.8e-11 43.7 0.1 9.2e-10 38.8 0.1 2.1 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EFE44636.1 - 7.4e-07 29.0 0.2 1.6e-06 27.9 0.2 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 EFE44636.1 - 3.4e-06 26.9 0.1 0.0024 17.5 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C WD40 PF00400.32 EFE44637.1 - 9.1e-33 111.8 22.3 2.4e-07 31.3 0.6 7.9 8 0 0 8 8 8 5 WD domain, G-beta repeat PRP4 PF08799.11 EFE44637.1 - 2.2e-14 52.7 0.8 4.2e-14 51.8 0.8 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 EFE44637.1 - 3.1e-11 43.4 0.1 0.055 13.8 0.0 5.5 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFE44637.1 - 0.0011 18.3 0.0 0.14 11.4 0.0 2.5 2 0 0 2 2 2 2 WD40-like domain Nbas_N PF15492.6 EFE44637.1 - 0.068 12.5 0.0 3.5 6.9 0.0 2.5 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal F-box-like PF12937.7 EFE44638.1 - 0.00027 20.8 0.5 0.00027 20.8 0.5 2.3 2 0 0 2 2 2 1 F-box-like ATP-synt_D PF01813.17 EFE44638.1 - 0.0017 18.2 0.1 0.0032 17.3 0.1 1.4 1 0 0 1 1 1 1 ATP synthase subunit D F-box PF00646.33 EFE44638.1 - 0.023 14.6 2.7 0.023 14.6 1.0 1.9 2 0 0 2 2 2 0 F-box domain 3Beta_HSD PF01073.19 EFE44639.1 - 2.3e-10 39.9 0.2 5e-10 38.9 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFE44639.1 - 5.7e-07 29.2 0.0 1.8e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFE44639.1 - 1.5e-05 25.0 0.0 2.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EFE44639.1 - 0.006 15.8 0.0 0.045 12.9 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EFE44639.1 - 0.045 13.3 0.1 0.15 11.6 0.1 1.8 2 0 0 2 2 2 0 NmrA-like family Polysacc_synt_2 PF02719.15 EFE44639.1 - 0.097 11.8 0.2 0.15 11.2 0.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein HSCB_C PF07743.13 EFE44640.1 - 5.9e-19 68.3 2.1 7.8e-19 67.9 0.6 1.8 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EFE44640.1 - 4e-05 23.7 0.1 0.00022 21.3 0.0 2.1 2 0 0 2 2 2 1 DnaJ domain DUF4352 PF11611.8 EFE44640.1 - 0.034 14.4 0.0 0.057 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4352) CDC45 PF02724.14 EFE44641.1 - 0.32 9.2 3.9 0.5 8.6 3.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Mitofilin PF09731.9 EFE44641.1 - 1 8.1 15.8 1.3 7.7 15.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SHD1 PF03983.12 EFE44642.1 - 1.9e-33 114.1 0.0 3.4e-33 113.3 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.28 EFE44642.1 - 5.6e-33 112.3 3.9 1.7e-11 43.5 0.1 4.4 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 EFE44642.1 - 8.1e-31 105.6 5.0 2.8e-11 43.1 0.1 4.0 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 EFE44642.1 - 3.9e-21 74.5 0.3 1.3e-07 31.2 0.0 4.6 4 0 0 4 4 4 4 Variant SH3 domain SAM_4 PF18017.1 EFE44642.1 - 4.4e-05 23.4 0.0 0.00014 21.7 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_3 PF08239.11 EFE44642.1 - 0.35 11.2 1.1 4.1 7.7 0.1 2.8 3 0 0 3 3 3 0 Bacterial SH3 domain PRKCSH PF07915.13 EFE44643.1 - 6.1e-19 68.8 0.1 6.1e-19 68.8 0.1 2.9 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 EFE44643.1 - 0.046 13.4 0.4 0.15 11.7 0.4 1.9 1 1 0 1 1 1 0 Glucosidase II beta subunit-like protein STT3 PF02516.14 EFE44644.1 - 3e-133 445.3 38.9 7.2e-119 397.9 31.7 3.2 3 0 0 3 3 3 3 Oligosaccharyl transferase STT3 subunit APH PF01636.23 EFE44646.1 - 2e-17 63.9 0.0 5.3e-17 62.5 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFE44646.1 - 2.9e-05 23.5 0.0 0.2 11.0 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFE44646.1 - 0.00015 21.5 0.0 0.00021 21.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EFE44646.1 - 0.035 13.7 0.0 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 RIO1 family APH_6_hur PF04655.14 EFE44646.1 - 0.081 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Pox_ser-thr_kin PF05445.11 EFE44646.1 - 0.1 11.6 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase PF00069.25 EFE44646.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Pirin PF02678.16 EFE44647.1 - 3.1e-30 104.3 0.1 6.4e-30 103.3 0.1 1.5 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EFE44647.1 - 1e-24 86.8 0.0 3.1e-24 85.3 0.0 1.7 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EFE44647.1 - 0.00011 21.9 1.7 0.0023 17.6 1.1 2.5 2 1 0 2 2 2 1 Cupin domain Tmem26 PF09772.9 EFE44647.1 - 0.18 11.1 0.4 0.27 10.5 0.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 26 PMT PF02366.18 EFE44648.1 - 4.2e-86 288.5 15.5 6.8e-86 287.8 15.5 1.3 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EFE44648.1 - 1.2e-68 230.6 2.7 1.2e-68 230.6 2.7 2.7 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EFE44648.1 - 2e-20 73.4 0.5 4.2e-20 72.4 0.5 1.5 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 EFE44648.1 - 0.0044 17.2 3.6 0.0044 17.2 3.6 3.1 3 1 0 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase HTH_AraC PF00165.23 EFE44649.1 - 0.11 12.6 0.0 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family WD40 PF00400.32 EFE44650.1 - 0.00045 21.0 11.6 2.4 9.2 0.1 5.8 6 1 0 6 6 6 3 WD domain, G-beta repeat ATP-synt_E PF05680.12 EFE44651.1 - 3.9e-22 78.4 0.2 4e-22 78.4 0.2 1.0 1 0 0 1 1 1 1 ATP synthase E chain Drf_GBD PF06371.13 EFE44651.1 - 0.13 11.8 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Adhesin_P1_N PF18652.1 EFE44651.1 - 0.61 10.1 3.7 1.1 9.3 3.7 1.6 1 1 0 1 1 1 0 Adhesin P1 N-terminal domain CSN8_PSD8_EIF3K PF10075.9 EFE44652.1 - 3.4e-15 56.3 0.0 4.9e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 EFE44652.1 - 0.13 12.7 0.0 0.3 11.6 0.0 1.7 1 1 0 1 1 1 0 PCI domain DUF3453 PF11935.8 EFE44653.1 - 3.1e-41 141.5 0.3 1.4e-38 132.8 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3453) Sds3 PF08598.11 EFE44654.1 - 6.2e-12 46.0 0.8 6.2e-12 46.0 0.8 2.3 2 1 0 2 2 2 1 Sds3-like DUF4940 PF16298.5 EFE44654.1 - 0.15 11.7 0.1 0.47 10.1 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4940) DUF553 PF04473.12 EFE44655.1 - 0.1 12.1 0.6 0.46 10.0 0.6 1.9 1 1 0 1 1 1 0 Transglutaminase-like domain RRM_1 PF00076.22 EFE44656.1 - 3.8e-11 42.6 0.0 9.5e-07 28.6 0.0 3.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GPI-anchored PF10342.9 EFE44657.1 - 1.5e-16 60.9 0.0 1.5e-16 60.9 0.0 2.8 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Hydin_ADK PF17213.3 EFE44657.1 - 0.16 12.2 4.9 0.26 11.5 4.9 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain SOG2 PF10428.9 EFE44657.1 - 0.66 9.1 16.1 0.7 9.0 16.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein NUFIP1 PF10453.9 EFE44658.1 - 7.7e-08 32.1 15.6 7.7e-08 32.1 15.6 4.4 2 1 2 4 4 4 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.24 EFE44658.1 - 5.5e-07 29.3 5.8 9e-07 28.7 5.8 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFE44658.1 - 0.00011 22.2 5.0 0.00019 21.4 5.0 1.4 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 EFE44658.1 - 0.0081 16.9 0.9 0.0081 16.9 0.9 3.2 2 1 1 3 3 3 1 Torus domain zf-CCCH_4 PF18044.1 EFE44658.1 - 0.0086 15.9 4.1 0.013 15.3 4.1 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger RNA_pol_Rbc25 PF08292.12 EFE44659.1 - 9.9e-16 58.1 1.9 2e-08 34.5 0.0 3.3 3 0 0 3 3 3 3 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EFE44659.1 - 5.9e-13 49.0 0.0 1.3e-12 47.9 0.0 1.6 1 1 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Cys_Met_Meta_PP PF01053.20 EFE44660.1 - 2.2e-67 227.3 0.3 2.5e-67 227.1 0.3 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EFE44660.1 - 4.9e-06 26.0 0.0 6.5e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EFE44660.1 - 0.0013 18.2 0.7 0.0026 17.1 0.7 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EFE44660.1 - 0.0027 16.7 0.6 0.0032 16.5 0.1 1.3 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFE44660.1 - 0.0055 16.0 0.0 0.0083 15.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Crinivirus_P26 PF07416.11 EFE44660.1 - 0.043 13.5 0.0 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Crinivirus P26 protein Peptidase_S49_N PF08496.10 EFE44661.1 - 0.38 10.8 1.8 0.58 10.2 1.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF1180 PF06679.12 EFE44661.1 - 0.55 10.6 2.3 0.76 10.2 2.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Phage_holin_3_6 PF07332.11 EFE44661.1 - 0.92 9.6 10.8 1.4 8.9 10.8 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Peptidase_S8 PF00082.22 EFE44662.1 - 1.4e-33 116.5 15.0 4.8e-33 114.7 15.1 1.7 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE44662.1 - 3.1e-17 63.0 0.1 9.6e-17 61.4 0.0 1.9 2 0 0 2 2 2 1 Peptidase inhibitor I9 AAT PF03417.16 EFE44663.1 - 1.3e-38 132.9 0.0 1.6e-38 132.7 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase 2OG-FeII_Oxy PF03171.20 EFE44664.1 - 1.2e-13 51.4 0.1 3.3e-13 50.0 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EFE44664.1 - 3.9e-13 50.2 0.0 5.9e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Condensation PF00668.20 EFE44665.1 - 2.8e-238 791.1 10.6 4.9e-91 305.7 2.6 5.0 5 0 0 5 5 5 4 Condensation domain AMP-binding PF00501.28 EFE44665.1 - 1.6e-235 781.4 0.0 7.7e-87 291.6 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme PP-binding PF00550.25 EFE44665.1 - 1.1e-51 173.0 0.6 4.6e-16 58.9 0.1 4.0 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFE44665.1 - 7.6e-27 94.1 0.0 9.9e-11 42.5 0.0 3.8 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain Thioesterase PF00975.20 EFE44665.1 - 2.6e-25 89.9 0.0 5.7e-25 88.8 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EFE44665.1 - 0.00073 20.2 0.3 0.0072 17.0 0.0 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family AATase PF07247.12 EFE44665.1 - 0.0024 16.5 2.4 0.015 13.9 0.1 2.6 2 0 0 2 2 2 1 Alcohol acetyltransferase Hydrolase_4 PF12146.8 EFE44665.1 - 0.1 11.8 0.0 0.26 10.5 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ank_2 PF12796.7 EFE44667.1 - 0.0016 19.0 0.1 0.0041 17.7 0.1 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFE44667.1 - 0.0022 18.2 0.1 0.0056 17.0 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFE44667.1 - 0.01 16.4 0.1 0.034 14.7 0.0 1.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) GST_N PF02798.20 EFE44668.1 - 7.6e-12 45.4 0.0 1.2e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFE44668.1 - 3.6e-09 36.9 0.1 1.2e-08 35.2 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFE44668.1 - 6.2e-07 29.6 0.0 1e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFE44668.1 - 3.2e-05 24.1 0.0 5.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFE44668.1 - 0.0029 17.8 0.0 0.0046 17.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE44668.1 - 0.022 14.8 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ICL PF00463.21 EFE44671.1 - 4.4e-295 979.1 0.6 5e-295 978.9 0.6 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EFE44671.1 - 9.6e-12 44.9 0.1 3.3e-11 43.1 0.0 1.8 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Trehalase PF01204.18 EFE44672.1 - 1.1e-196 654.6 0.0 1.3e-196 654.4 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EFE44672.1 - 7.4e-17 60.8 0.1 1.2e-16 60.1 0.1 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain DUF4024 PF13216.6 EFE44672.1 - 0.064 13.2 0.2 0.13 12.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4024) adh_short PF00106.25 EFE44673.1 - 5.2e-42 143.5 0.0 6.8e-42 143.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE44673.1 - 1.4e-41 142.6 0.0 1.1e-40 139.7 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE44673.1 - 6.2e-05 23.0 0.0 0.00012 22.0 0.0 1.4 1 0 0 1 1 1 1 KR domain HTH_Tnp_IS1 PF12759.7 EFE44673.1 - 0.048 13.3 0.1 73 3.1 0.0 3.3 3 0 0 3 3 3 0 InsA C-terminal domain THF_DHG_CYH_C PF02882.19 EFE44673.1 - 0.092 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain OTU PF02338.19 EFE44674.1 - 1e-19 71.2 0.1 2.7e-19 69.9 0.0 1.8 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EFE44674.1 - 9.2e-06 25.3 0.0 0.01 15.3 0.0 2.5 1 1 1 2 2 2 2 Peptidase C65 Otubain DUF4407 PF14362.6 EFE44674.1 - 0.01 15.3 10.8 0.014 14.7 10.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF4551 PF15087.6 EFE44674.1 - 0.95 8.2 10.1 1.2 7.9 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) TPMT PF05724.11 EFE44675.1 - 3.1e-16 59.7 0.5 2.6e-15 56.7 0.5 1.9 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 EFE44675.1 - 1.3e-06 28.3 0.2 5.1e-06 26.4 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE44675.1 - 0.00012 22.7 0.0 0.00022 21.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE44675.1 - 0.00014 22.4 0.0 0.00025 21.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain N2227 PF07942.12 EFE44675.1 - 0.018 14.3 0.0 0.024 13.8 0.0 1.1 1 0 0 1 1 1 0 N2227-like protein AdoMet_MTase PF07757.13 EFE44675.1 - 0.093 13.1 0.5 0.19 12.1 0.5 1.8 1 1 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase MFS_1 PF07690.16 EFE44676.1 - 2.1e-46 158.5 42.3 4.1e-38 131.2 25.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE44676.1 - 1.1e-06 27.8 12.8 1.1e-06 27.8 12.8 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter DUF3295 PF11702.8 EFE44678.1 - 5.2e-172 573.6 42.1 5.2e-172 573.6 42.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3295) DUF1752 PF08550.10 EFE44678.1 - 1.9e-06 27.6 5.3 6.1e-06 26.0 5.3 1.9 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) ParBc PF02195.18 EFE44678.1 - 0.0084 16.4 0.6 0.26 11.6 0.1 3.0 2 1 0 2 2 2 1 ParB-like nuclease domain Polysacc_deac_1 PF01522.21 EFE44679.1 - 4.1e-21 75.2 0.0 7.8e-20 71.0 0.0 2.1 1 1 0 1 1 1 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 EFE44679.1 - 0.091 11.9 0.0 0.2 10.8 0.0 1.6 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase RWD PF05773.22 EFE44680.1 - 0.018 15.3 0.1 0.94 9.8 0.0 2.5 2 0 0 2 2 2 0 RWD domain zinc_ribbon_15 PF17032.5 EFE44680.1 - 0.077 13.8 2.3 1.5 9.7 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon family zf-RRPl_C4 PF17026.5 EFE44680.1 - 3.8 7.7 5.0 2 8.6 0.2 2.4 2 1 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type GLTSCR1 PF15249.6 EFE44681.1 - 0.14 12.6 0.0 0.21 12.1 0.0 1.3 1 0 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein Rsm1 PF08600.10 EFE44682.1 - 3.2e-24 84.9 0.0 3.2e-24 84.9 0.0 2.6 2 1 1 3 3 3 1 Rsm1-like zf-C3HC PF07967.13 EFE44682.1 - 4.5e-23 81.7 1.5 7.8e-20 71.3 0.1 3.4 2 2 1 3 3 3 2 C3HC zinc finger-like Pox_MCEL PF03291.16 EFE44683.1 - 4.7e-62 210.0 0.0 5.4e-41 140.8 0.0 3.2 2 1 0 2 2 2 2 mRNA capping enzyme Methyltransf_12 PF08242.12 EFE44683.1 - 9.3e-10 39.1 0.1 6.7e-08 33.2 0.0 3.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE44683.1 - 2e-09 38.0 0.0 0.0013 19.4 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EFE44683.1 - 2.5e-06 28.1 0.1 0.032 14.9 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.6 EFE44683.1 - 4.1e-05 23.4 0.0 0.079 12.8 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EFE44683.1 - 0.00036 19.8 0.0 0.00065 19.0 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.6 EFE44683.1 - 0.004 17.0 0.7 0.01 15.7 0.0 2.0 3 0 0 3 3 3 1 Methyltransferase domain Hid1 PF12722.7 EFE44683.1 - 5.7 4.9 10.8 9.1 4.3 10.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein zf-Nse PF11789.8 EFE44684.1 - 9.5e-22 76.6 2.1 1.6e-21 75.8 2.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EFE44684.1 - 8.4e-05 22.5 1.5 0.00046 20.1 0.1 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFE44684.1 - 0.052 13.4 0.5 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) KRAB PF01352.27 EFE44684.1 - 0.084 12.5 0.2 0.16 11.7 0.2 1.5 1 0 0 1 1 1 0 KRAB box Pap_E4 PF02711.14 EFE44684.1 - 0.21 12.6 0.1 0.21 12.6 0.1 3.8 3 0 0 3 3 3 0 E4 protein zf-MIZ PF02891.20 EFE44684.1 - 0.34 10.7 3.8 0.35 10.7 0.1 2.2 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Mito_carr PF00153.27 EFE44685.1 - 1.2e-50 169.3 3.2 1e-15 57.4 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Tir_receptor_N PF07490.11 EFE44685.1 - 0.00033 20.6 1.2 0.00058 19.8 1.2 1.3 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) N-terminus Presenilin PF01080.17 EFE44687.1 - 0.45 9.2 2.5 0.53 9.0 2.5 1.1 1 0 0 1 1 1 0 Presenilin Copper-fist PF00649.18 EFE44688.1 - 6.1e-23 80.0 1.4 1.7e-22 78.6 1.4 1.8 1 0 0 1 1 1 1 Copper fist DNA binding domain Zn_clus PF00172.18 EFE44689.1 - 9.5e-11 41.6 9.6 1.4e-10 41.1 9.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4078 PF13300.6 EFE44689.1 - 0.077 13.3 0.0 0.077 13.3 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4078) TFIIA PF03153.13 EFE44689.1 - 1.4 8.8 20.4 1 9.3 19.0 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Utp21 PF04192.12 EFE44690.1 - 1.2e-76 257.3 0.1 1.2e-76 257.3 0.1 1.6 2 0 0 2 2 2 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EFE44690.1 - 1.1e-13 51.4 27.0 0.00029 21.6 0.4 10.6 11 1 0 11 11 11 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE44690.1 - 8.1e-11 42.1 0.2 0.0013 19.0 0.0 6.7 3 2 4 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE44690.1 - 0.00013 20.8 0.1 0.82 8.2 0.0 3.1 3 0 0 3 3 3 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EFE44690.1 - 0.15 11.0 3.3 1 8.2 0.0 3.3 4 1 1 5 5 5 0 Partner and localizer of BRCA2 WD40 domain FeoB_associated PF12669.7 EFE44691.1 - 0.13 12.6 0.8 0.22 11.9 0.8 1.2 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF383 PF04063.14 EFE44692.1 - 2.4e-40 138.2 4.4 5.1e-23 81.7 0.0 3.4 3 1 1 4 4 4 2 Domain of unknown function (DUF383) DUF384 PF04064.13 EFE44692.1 - 1.3e-21 76.2 2.8 1.5e-21 76.0 1.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF384) SPO22 PF08631.10 EFE44692.1 - 0.026 14.0 0.3 0.16 11.4 0.1 2.1 2 1 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like Peptidase_C50 PF03568.17 EFE44692.1 - 0.096 11.8 0.1 0.17 10.9 0.1 1.5 1 0 0 1 1 1 0 Peptidase family C50 ArgJ PF01960.18 EFE44692.1 - 0.096 11.4 0.2 0.15 10.7 0.2 1.2 1 0 0 1 1 1 0 ArgJ family Rep-A_N PF04057.12 EFE44693.1 - 0.00052 20.0 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain BRCA-2_OB1 PF09103.10 EFE44693.1 - 0.0089 16.0 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 GP79 PF17463.2 EFE44693.1 - 0.18 11.8 0.0 0.46 10.5 0.0 1.6 1 0 0 1 1 1 0 Gene product 79 PAP_assoc PF03828.19 EFE44694.1 - 5.3e-08 33.0 0.0 1.9e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EFE44694.1 - 0.048 14.0 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase domain TFIIF_alpha PF05793.12 EFE44695.1 - 9.1e-06 24.5 75.2 0.00022 20.0 71.2 3.8 1 1 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Herpes_LMP2 PF07415.11 EFE44695.1 - 1.6 7.4 3.8 3.3 6.4 3.8 1.4 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Transglut_i_TM PF14400.6 EFE44696.1 - 0.03 14.4 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 Inactive transglutaminase fused to 7 transmembrane helices His_Phos_2 PF00328.22 EFE44697.1 - 1.4e-106 357.1 0.0 1.8e-106 356.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EFE44697.1 - 9.8e-38 128.2 0.0 2e-37 127.2 0.0 1.5 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EFE44697.1 - 9.9e-05 22.0 0.0 0.00019 21.1 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Abhydrolase_2 PF02230.16 EFE44698.1 - 3.9e-20 72.6 0.0 1.9e-14 54.0 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EFE44698.1 - 0.012 15.1 0.0 0.028 13.9 0.0 1.4 1 1 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFE44698.1 - 0.048 12.9 0.1 0.22 10.7 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 APH PF01636.23 EFE44700.1 - 3.1e-09 37.1 0.0 5e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE44700.1 - 0.042 13.4 0.0 0.18 11.3 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF4091 PF13320.6 EFE44700.1 - 0.065 13.4 0.3 0.12 12.5 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4091) DUF1840 PF08895.11 EFE44700.1 - 0.17 12.2 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) DUF4982 PF16355.5 EFE44701.1 - 0.067 13.1 0.0 0.068 13.1 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4982) UCH PF00443.29 EFE44702.1 - 3.1e-53 180.9 0.1 4.4e-53 180.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFE44702.1 - 1.2e-23 84.3 2.5 1.2e-23 84.3 2.5 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf_C2H2_ZHX PF18387.1 EFE44702.1 - 0.1 12.3 4.2 3.7 7.3 0.1 3.6 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain DASH_Dam1 PF08653.10 EFE44703.1 - 1.2e-22 79.4 1.0 1.2e-22 79.4 1.0 1.7 2 0 0 2 2 2 1 DASH complex subunit Dam1 DC_STAMP PF07782.13 EFE44703.1 - 0.086 12.7 0.1 0.21 11.4 0.0 1.6 1 1 1 2 2 2 0 DC-STAMP-like protein CRAL_TRIO PF00650.20 EFE44704.1 - 5.9e-38 130.1 0.0 1.5e-37 128.8 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFE44704.1 - 2.3e-13 50.1 0.1 6.7e-13 48.6 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFE44704.1 - 8e-06 26.1 0.0 1.5e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Peptidase_M20 PF01546.28 EFE44706.1 - 9.3e-29 100.6 0.3 1.5e-28 99.9 0.2 1.4 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFE44706.1 - 2e-05 24.5 0.0 5.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFE44706.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 S10_plectin PF03501.15 EFE44707.1 - 1.3e-24 86.1 0.4 1.6e-24 85.8 0.4 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Sde2_N_Ubi PF13019.6 EFE44708.1 - 2.2e-68 229.2 0.1 2.2e-68 229.2 0.1 1.5 2 0 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain Cep57_MT_bd PF06657.13 EFE44708.1 - 0.2 12.2 1.9 0.4 11.2 1.9 1.5 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 MMR_HSR1 PF01926.23 EFE44709.1 - 3.3e-05 23.9 0.3 0.16 12.1 0.2 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EFE44709.1 - 0.046 13.2 0.1 7.5 6.1 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA PF00004.29 EFE44710.1 - 1.3e-36 125.9 0.0 2.2e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFE44710.1 - 2.2e-11 43.6 0.0 1.1e-07 31.7 0.0 3.5 3 0 0 3 3 3 2 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EFE44710.1 - 1.6e-08 34.2 0.1 4.3e-08 32.8 0.0 1.8 2 0 0 2 2 1 1 AAA+ lid domain AAA_22 PF13401.6 EFE44710.1 - 5.7e-05 23.4 0.1 0.00041 20.6 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EFE44710.1 - 0.00012 22.2 0.0 0.00021 21.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFE44710.1 - 0.00012 21.8 0.0 0.00023 20.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFE44710.1 - 0.00035 21.0 1.9 0.0055 17.1 0.1 3.3 4 1 0 4 4 3 1 AAA ATPase domain AAA_5 PF07728.14 EFE44710.1 - 0.0021 18.1 0.1 0.01 15.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFE44710.1 - 0.0037 16.5 0.0 0.0071 15.6 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EFE44710.1 - 0.0058 16.0 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EFE44710.1 - 0.0093 15.7 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 EFE44710.1 - 0.032 13.4 0.0 0.054 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 EFE44710.1 - 0.054 14.0 0.0 0.17 12.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EFE44710.1 - 0.067 12.6 0.0 2.2 7.7 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 EFE44710.1 - 0.077 12.5 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EFE44710.1 - 0.08 13.1 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFE44710.1 - 0.093 12.8 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EFE44710.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 EFE44710.1 - 0.11 12.1 0.0 0.37 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFE44710.1 - 0.19 11.9 0.6 2.3 8.5 0.0 2.6 3 0 0 3 3 3 0 AAA domain Ribosomal_S17 PF00366.20 EFE44711.1 - 1.6e-13 50.5 0.7 2.7e-13 49.8 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 A_deaminase PF00962.22 EFE44712.1 - 1.9e-21 76.8 0.0 3.4e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase Mt_ATP-synt_B PF05405.14 EFE44712.1 - 0.027 14.1 0.5 0.046 13.3 0.5 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) ATG2_CAD PF13329.6 EFE44713.1 - 1.1e-43 148.6 0.0 2.7e-43 147.4 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 EFE44713.1 - 1.1e-25 89.8 0.3 4.1e-25 88.0 0.1 2.1 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 EFE44713.1 - 0.002 17.9 0.1 0.0097 15.7 0.0 2.1 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal MFMR PF07777.11 EFE44714.1 - 0.039 14.4 0.4 0.069 13.6 0.4 1.6 1 1 0 1 1 1 0 G-box binding protein MFMR Condensation PF00668.20 EFE44717.1 - 2.3e-77 260.6 0.0 3.6e-77 260.0 0.0 1.2 1 0 0 1 1 1 1 Condensation domain ketoacyl-synt PF00109.26 EFE44717.1 - 3.3e-72 243.1 0.0 7.1e-72 242.0 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 EFE44717.1 - 1.8e-62 211.4 0.0 6.5e-61 206.2 0.0 2.2 1 1 0 1 1 1 1 AMP-binding enzyme PS-DH PF14765.6 EFE44717.1 - 1.7e-60 204.8 0.0 2.6e-60 204.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EFE44717.1 - 3.6e-59 199.7 0.1 1.3e-58 197.9 0.0 2.1 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EFE44717.1 - 5.6e-56 190.4 0.0 1e-55 189.5 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFE44717.1 - 3.5e-40 136.7 0.1 1.7e-39 134.5 0.1 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 EFE44717.1 - 6.1e-36 123.9 0.0 1.2e-35 122.9 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein KAsynt_C_assoc PF16197.5 EFE44717.1 - 9.1e-23 80.9 0.0 3.6e-22 78.9 0.0 2.1 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EFE44717.1 - 1.3e-20 73.5 0.2 1.7e-10 41.1 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site ADH_zinc_N PF00107.26 EFE44717.1 - 2.9e-18 66.1 0.0 2.5e-17 63.1 0.0 2.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFE44717.1 - 1.5e-17 64.9 0.0 2.4e-16 61.0 0.0 3.0 3 0 0 3 3 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EFE44717.1 - 1.2e-07 31.4 0.2 3.8e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE44717.1 - 3e-05 23.7 0.0 6.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 EFE44717.1 - 0.00092 18.6 0.0 0.0024 17.3 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain AMP-binding_C PF13193.6 EFE44717.1 - 0.0022 18.9 0.0 0.006 17.5 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1233 PF06806.12 EFE44717.1 - 0.087 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 Putative excisionase (DUF1233) p450 PF00067.22 EFE44718.1 - 9.1e-52 176.3 0.0 1.5e-51 175.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 DUF2953 PF11167.8 EFE44718.1 - 0.13 12.4 0.1 0.41 10.7 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) Asp PF00026.23 EFE44719.1 - 5.6e-13 49.0 0.5 2.8e-08 33.5 0.0 2.2 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.6 EFE44719.1 - 0.028 14.2 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Thioesterase PF00975.20 EFE44720.1 - 3.6e-20 73.1 0.1 6.6e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.20 EFE44720.1 - 1.8e-05 24.5 0.0 2.9e-05 23.9 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFE44720.1 - 2.3e-05 25.1 0.0 2.3e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 EFE44720.1 - 0.054 13.2 0.0 0.38 10.5 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EFE44720.1 - 0.16 11.8 0.1 0.32 10.8 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold FAD_binding_3 PF01494.19 EFE44721.1 - 2e-20 73.4 0.1 4.6e-19 68.9 0.1 2.1 1 1 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EFE44721.1 - 2e-07 30.3 1.2 2.8e-05 23.2 0.0 2.2 1 1 1 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 EFE44721.1 - 8.4e-06 25.2 0.4 0.024 13.9 0.1 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFE44721.1 - 1.6e-05 24.2 0.0 2.9e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EFE44721.1 - 0.0014 18.8 0.2 0.0041 17.3 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFE44721.1 - 0.035 14.7 0.0 0.092 13.3 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFE44721.1 - 0.045 13.0 0.5 0.088 12.0 0.1 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFE44721.1 - 0.35 10.4 1.8 0.57 9.7 0.6 1.8 1 1 1 2 2 2 0 FAD dependent oxidoreductase Fungal_trans PF04082.18 EFE44722.1 - 3.3e-07 29.6 2.3 5.2e-07 29.0 2.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain CN_hydrolase PF00795.22 EFE44723.1 - 4.1e-56 190.2 0.0 4.9e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Ribosomal_L31e PF01198.19 EFE44724.1 - 3.8e-31 107.2 0.4 6.4e-31 106.4 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L31e Ran_BP1 PF00638.18 EFE44725.1 - 3.8e-13 49.8 0.0 8.8e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.6 EFE44725.1 - 3.4 8.6 202.9 0.037 14.9 19.9 11.1 3 3 6 9 9 9 0 Nucleoporin FG repeat region SCP2 PF02036.17 EFE44726.1 - 3.4e-24 85.3 0.1 4.7e-24 84.8 0.1 1.2 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EFE44726.1 - 0.00024 21.3 0.0 0.00032 20.9 0.0 1.2 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 EFE44726.1 - 0.033 14.6 0.0 0.047 14.1 0.0 1.3 1 0 0 1 1 1 0 Sterol carrier protein domain F-box-like PF12937.7 EFE44727.1 - 0.0024 17.7 0.2 0.47 10.4 0.0 2.5 2 0 0 2 2 2 2 F-box-like SNF2_N PF00176.23 EFE44728.1 - 1.7e-61 207.9 0.4 3.7e-61 206.8 0.4 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFE44728.1 - 2.5e-14 53.5 0.0 5.9e-14 52.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 EFE44728.1 - 1e-08 34.9 1.8 3.2e-08 33.3 1.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFE44728.1 - 5.2e-08 32.6 2.9 1.2e-07 31.5 2.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EFE44728.1 - 2.8e-06 27.5 0.0 6.2e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 EFE44728.1 - 6.4e-06 25.9 3.9 1.4e-05 24.9 3.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFE44728.1 - 3.8e-05 23.9 4.0 9.3e-05 22.7 4.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFE44728.1 - 0.0001 22.2 3.7 0.00023 21.1 3.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFE44728.1 - 0.00021 21.3 2.5 0.00054 19.9 2.5 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFE44728.1 - 0.0024 17.7 5.7 0.01 15.7 5.7 2.1 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EFE44728.1 - 0.0031 17.3 3.5 0.0077 16.0 3.5 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EFE44728.1 - 0.019 15.1 5.7 0.042 14.0 5.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DZR PF12773.7 EFE44728.1 - 0.063 13.3 2.9 0.16 12.1 3.0 1.7 1 1 0 1 1 1 0 Double zinc ribbon CCDC50_N PF15295.6 EFE44728.1 - 0.67 10.1 7.4 1.7 8.8 7.4 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Arginosuc_synth PF00764.19 EFE44729.1 - 3.9e-82 276.6 0.0 6.1e-46 157.5 0.0 2.0 2 0 0 2 2 2 2 Arginosuccinate synthase DUF2624 PF11116.8 EFE44729.1 - 0.16 12.9 0.0 0.3 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) MAD PF05557.13 EFE44730.1 - 8.5e-56 189.6 76.4 2.2e-47 161.8 77.5 2.3 2 1 0 2 2 2 2 Mitotic checkpoint protein Dict-STAT-coil PF09267.10 EFE44730.1 - 0.005 17.2 3.0 0.005 17.2 3.0 4.7 4 2 2 6 6 6 1 Dictyostelium STAT, coiled coil DUF5082 PF16888.5 EFE44730.1 - 0.016 15.5 14.0 0.016 15.5 14.0 5.6 6 0 0 6 6 6 0 Domain of unknown function (DUF5082) CC2-LZ PF16516.5 EFE44730.1 - 0.16 12.3 0.1 0.16 12.3 0.1 9.1 5 3 1 6 6 6 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Bacillus_HBL PF05791.11 EFE44730.1 - 7.2 6.4 26.9 0.36 10.7 7.0 6.1 5 1 1 7 7 7 0 Bacillus haemolytic enterotoxin (HBL) Peptidase_M20 PF01546.28 EFE44731.1 - 1.3e-28 100.1 0.6 1.2e-27 97.0 0.6 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFE44731.1 - 3e-17 62.5 0.0 7.2e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFE44731.1 - 0.00055 19.7 0.0 0.0015 18.3 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 muHD PF10291.9 EFE44732.1 - 3.4e-74 249.6 0.0 4.8e-74 249.1 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Laminin_II PF06009.12 EFE44732.1 - 0.0091 16.0 2.5 0.029 14.4 2.5 1.9 1 0 0 1 1 1 1 Laminin Domain II Caskin-tail PF16632.5 EFE44732.1 - 0.15 12.5 0.9 0.7 10.3 0.9 2.2 1 0 0 1 1 1 0 C-terminal region of Caskin Muted PF14942.6 EFE44732.1 - 1.9 8.8 4.8 0.52 10.6 1.5 1.7 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein SH3_9 PF14604.6 EFE44733.1 - 3.4e-08 33.2 0.0 5.5e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFE44733.1 - 4.1e-06 26.3 0.0 6.5e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFE44733.1 - 1.8e-05 24.3 0.0 3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Podoplanin PF05808.11 EFE44733.1 - 0.00083 19.5 0.3 0.00083 19.5 0.3 2.2 2 0 0 2 2 2 1 Podoplanin Apt1 PF10351.9 EFE44733.1 - 2.7 6.7 4.4 4.3 6.1 4.4 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain OPT PF03169.15 EFE44734.1 - 4.1e-160 534.4 20.9 4.7e-160 534.2 20.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Rav1p_C PF12234.8 EFE44735.1 - 2e-263 875.6 1.9 2.4e-249 829.1 1.0 2.4 2 1 1 3 3 3 2 RAVE protein 1 C terminal ANAPC4_WD40 PF12894.7 EFE44735.1 - 0.046 14.0 2.6 30 5.0 0.0 4.0 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFE44735.1 - 0.32 9.6 4.2 2.8 6.5 0.3 2.7 3 0 0 3 3 3 0 Nucleoporin Nup120/160 WD40 PF00400.32 EFE44735.1 - 4.5 8.3 17.6 23 6.1 0.1 6.0 6 1 0 7 7 7 0 WD domain, G-beta repeat Ferritin_2 PF13668.6 EFE44736.1 - 2.9e-17 63.2 0.0 4.3e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain PilN PF05137.13 EFE44736.1 - 0.087 13.0 0.2 6.8 6.9 0.1 2.4 2 0 0 2 2 2 0 Fimbrial assembly protein (PilN) Fungal_trans PF04082.18 EFE44737.1 - 1.3e-14 53.9 0.2 1.3e-14 53.9 0.2 2.2 3 0 0 3 3 3 1 Fungal specific transcription factor domain 2-oxogl_dehyd_N PF16078.5 EFE44737.1 - 0.027 14.1 0.0 0.071 12.7 0.0 1.7 1 0 0 1 1 1 0 2-oxoglutarate dehydrogenase N-terminus Spore_YpjB PF09577.10 EFE44737.1 - 0.073 12.9 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) Striatin PF08232.12 EFE44737.1 - 0.16 12.6 0.9 0.29 11.7 0.9 1.4 1 0 0 1 1 1 0 Striatin family SR-25 PF10500.9 EFE44738.1 - 0.034 13.8 5.1 0.038 13.6 5.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Arginosuc_synth PF00764.19 EFE44739.1 - 5.7e-25 88.4 0.1 6.5e-25 88.2 0.1 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EFE44739.1 - 0.00018 21.1 0.0 0.00019 21.0 0.0 1.1 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EFE44739.1 - 0.00086 18.2 0.0 0.00099 18.0 0.0 1.2 1 1 0 1 1 1 1 tRNA methyl transferase DNA_pol3_gamma3 PF12169.8 EFE44739.1 - 0.012 15.6 0.0 0.013 15.5 0.0 1.0 1 0 0 1 1 1 0 DNA polymerase III subunits gamma and tau domain III ATP_bind_3 PF01171.20 EFE44739.1 - 0.036 13.8 0.0 0.042 13.6 0.0 1.3 1 1 0 1 1 1 0 PP-loop family Asn_synthase PF00733.21 EFE44739.1 - 0.054 13.2 0.0 0.054 13.2 0.0 1.0 1 0 0 1 1 1 0 Asparagine synthase RasGEF PF00617.19 EFE44740.1 - 1.2e-38 133.1 0.2 2e-38 132.4 0.2 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFE44740.1 - 8.7e-14 51.6 0.2 1.9e-13 50.5 0.2 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif DIL PF01843.19 EFE44741.1 - 1.3e-29 102.5 1.1 1.3e-29 102.5 1.1 2.0 2 0 0 2 2 2 1 DIL domain Ank_2 PF12796.7 EFE44741.1 - 4.3e-13 49.7 0.2 1.8e-12 47.7 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFE44741.1 - 1.6e-09 37.8 0.0 4.5e-05 23.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFE44741.1 - 2.4e-09 37.2 0.5 0.0063 16.9 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFE44741.1 - 7.4e-08 32.8 0.4 0.00029 21.3 0.1 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE44741.1 - 1.9e-06 27.7 0.7 0.011 16.1 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeat Lin-8 PF03353.15 EFE44742.1 - 0.39 10.2 4.6 0.43 10.1 4.6 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Gtr1_RagA PF04670.12 EFE44744.1 - 6e-70 235.2 0.4 9.2e-70 234.6 0.4 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EFE44744.1 - 5.3e-05 22.7 0.0 9.4e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFE44744.1 - 0.0017 17.8 0.0 0.0043 16.5 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFE44744.1 - 0.0031 17.6 0.0 0.0073 16.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFE44744.1 - 0.007 16.6 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EFE44744.1 - 0.031 14.1 0.2 0.05 13.4 0.2 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Pkinase PF00069.25 EFE44745.1 - 2.5e-22 79.5 0.0 3.1e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44745.1 - 0.051 12.8 0.0 0.085 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EFE44745.1 - 0.089 12.7 0.3 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE44745.1 - 0.11 11.2 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase His_Phos_2 PF00328.22 EFE44746.1 - 2.9e-13 49.9 0.0 6.9e-12 45.4 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Lactamase_B_4 PF13691.6 EFE44747.1 - 2e-27 94.7 0.3 4.7e-26 90.3 0.1 2.8 3 0 0 3 3 3 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EFE44747.1 - 7.2e-14 51.8 0.1 4.2e-06 26.4 0.0 2.4 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFE44747.1 - 7.5e-05 22.8 0.2 0.00019 21.5 0.2 1.7 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily NAD_binding_10 PF13460.6 EFE44748.1 - 1.3e-19 70.8 0.0 1.8e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFE44748.1 - 0.002 17.6 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family LAM_C PF12544.8 EFE44748.1 - 0.073 13.3 0.5 0.48 10.6 0.1 2.3 3 0 0 3 3 3 0 Lysine-2,3-aminomutase Methyltransf_25 PF13649.6 EFE44749.1 - 5.4e-18 65.5 0.0 2.4e-17 63.4 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE44749.1 - 4.9e-16 59.2 0.0 4e-14 53.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE44749.1 - 3.4e-15 56.3 0.0 2e-13 50.5 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE44749.1 - 6.8e-15 55.2 0.0 1.1e-11 44.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFE44749.1 - 5.4e-13 49.5 0.0 4.2e-09 37.0 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain CMAS PF02353.20 EFE44749.1 - 1.2e-08 34.7 0.0 1.9e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 EFE44749.1 - 4.7e-06 26.4 0.0 0.00032 20.4 0.0 2.4 3 0 0 3 3 3 1 Nodulation protein S (NodS) Pox_MCEL PF03291.16 EFE44749.1 - 5.5e-05 22.4 0.0 0.00085 18.5 0.0 2.4 1 1 1 2 2 2 1 mRNA capping enzyme MetW PF07021.12 EFE44749.1 - 0.00023 20.8 0.0 0.0026 17.4 0.0 2.0 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW MTS PF05175.14 EFE44749.1 - 0.00036 20.1 0.0 0.0013 18.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EFE44749.1 - 0.00057 19.2 0.0 0.0022 17.3 0.0 1.9 2 0 0 2 2 2 1 O-methyltransferase domain CheR PF01739.18 EFE44749.1 - 0.00066 19.2 0.1 0.7 9.3 0.0 2.5 1 1 1 2 2 2 2 CheR methyltransferase, SAM binding domain TPMT PF05724.11 EFE44749.1 - 0.0011 18.7 0.0 0.0027 17.4 0.0 1.8 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Ubie_methyltran PF01209.18 EFE44749.1 - 0.0064 15.8 0.0 0.03 13.7 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EFE44749.1 - 0.0078 15.2 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) TehB PF03848.14 EFE44749.1 - 0.0079 15.6 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB PCMT PF01135.19 EFE44749.1 - 0.016 15.0 0.0 0.041 13.6 0.0 1.7 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0146 PF03686.13 EFE44749.1 - 0.022 14.6 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Methyltransf_32 PF13679.6 EFE44749.1 - 0.039 13.9 0.0 0.069 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain bZIP_1 PF00170.21 EFE44751.1 - 3.1e-08 33.6 9.3 3.1e-08 33.6 9.3 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFE44751.1 - 0.00076 19.5 11.1 0.00076 19.5 11.1 2.6 2 0 0 2 2 2 1 Basic region leucine zipper PAT1 PF09770.9 EFE44751.1 - 0.21 9.8 50.2 0.41 8.9 35.0 2.3 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Dus PF01207.17 EFE44752.1 - 6e-59 199.6 0.0 1.4e-58 198.5 0.0 1.5 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF908 PF06012.12 EFE44752.1 - 0.097 12.1 0.2 4.3 6.6 0.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) DHO_dh PF01180.21 EFE44752.1 - 0.12 11.6 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase APH PF01636.23 EFE44753.1 - 3.1e-07 30.6 0.0 7.4e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE44753.1 - 0.0011 17.9 0.0 0.064 12.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) EcKinase PF02958.20 EFE44753.1 - 0.019 14.3 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 EFE44753.1 - 0.15 11.6 0.1 0.33 10.5 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase CENP-X PF09415.10 EFE44755.1 - 1.5e-15 57.3 0.7 3.5e-15 56.1 0.7 1.7 1 0 0 1 1 1 1 CENP-S associating Centromere protein X PHC2_SAM_assoc PF16616.5 EFE44755.1 - 0.11 13.4 10.1 0.086 13.7 8.6 1.8 1 1 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Paramyxo_ncap PF00973.19 EFE44755.1 - 1.2 8.0 5.0 1.5 7.6 5.0 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DDHD PF02862.17 EFE44755.1 - 4.1 7.5 6.8 3 7.9 5.4 1.5 1 1 1 2 2 2 0 DDHD domain Mis12 PF05859.12 EFE44756.1 - 1.2e-47 161.4 0.0 2e-47 160.7 0.0 1.4 1 0 0 1 1 1 1 Mis12 protein ATG16 PF08614.11 EFE44756.1 - 0.027 14.7 0.7 0.37 11.0 0.2 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) MitoNEET_N PF10660.9 EFE44756.1 - 0.09 12.8 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus Trans_reg_C PF00486.28 EFE44757.1 - 0.02 15.0 0.5 0.058 13.5 0.2 1.9 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal SLATT_4 PF18186.1 EFE44758.1 - 0.13 11.9 1.3 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 DUF2371 PF10177.9 EFE44758.1 - 0.49 10.6 1.4 4.1 7.6 0.1 2.6 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2371) BCNT PF07572.12 EFE44759.1 - 1.8e-26 92.0 0.2 4.6e-26 90.7 0.2 1.7 1 0 0 1 1 1 1 Bucentaur or craniofacial development Acetyltransf_3 PF13302.7 EFE44760.1 - 8.2e-31 107.5 0.0 9.8e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFE44760.1 - 0.11 12.7 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Methyltransf_3 PF01596.17 EFE44761.1 - 7.4e-31 107.0 0.0 1.1e-30 106.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase PCMT PF01135.19 EFE44761.1 - 1.8e-10 41.0 0.0 2.5e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 EFE44761.1 - 1.2e-09 39.2 0.0 3e-09 37.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE44761.1 - 1.7e-08 34.4 0.0 2.4e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE44761.1 - 3.8e-07 30.7 0.0 7.9e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFE44761.1 - 0.00059 19.2 0.0 0.00079 18.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EFE44761.1 - 0.00062 19.3 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.12 EFE44761.1 - 0.001 19.7 0.0 0.0043 17.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE44761.1 - 0.023 15.4 0.0 0.053 14.3 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.10 EFE44761.1 - 0.039 13.6 0.0 0.05 13.3 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Spt20 PF12090.8 EFE44762.1 - 9.3e-54 182.5 0.7 9.3e-54 182.5 0.7 6.4 4 2 0 4 4 4 2 Spt20 family Fungal_lectin_2 PF18647.1 EFE44763.1 - 1.3e-43 147.6 1.9 3.3e-43 146.3 1.9 1.8 1 0 0 1 1 1 1 Alpha-galactosyl-binding fungal lectin Lipase_GDSL_2 PF13472.6 EFE44763.1 - 1e-13 52.0 0.0 2.8e-11 44.1 0.0 2.4 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFE44763.1 - 3.7e-10 40.1 0.0 8.8e-10 38.9 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Reprolysin_4 PF13583.6 EFE44764.1 - 0.0036 17.0 0.1 0.0061 16.2 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 EFE44764.1 - 0.021 14.5 1.3 0.21 11.2 0.4 2.6 3 0 0 3 3 3 0 Astacin (Peptidase family M12A) Reprolysin_2 PF13574.6 EFE44764.1 - 0.06 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 EFE44764.1 - 0.06 13.9 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 EFE44764.1 - 0.18 10.4 0.0 0.25 9.9 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_5 PF13688.6 EFE44764.1 - 0.22 11.6 0.6 0.41 10.8 0.6 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 EFE44764.1 - 0.48 10.2 3.6 0.81 9.5 2.3 2.1 2 1 0 2 2 2 0 Matrixin Glyco_hydro_18 PF00704.28 EFE44765.1 - 1.7e-51 175.8 0.0 2.6e-51 175.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EFE44766.1 - 3.3e-07 30.3 0.0 0.0013 18.7 0.0 2.4 2 0 0 2 2 2 2 LysM domain Hexapep PF00132.24 EFE44769.1 - 1.5e-06 27.7 2.2 0.022 14.5 0.3 3.6 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EFE44769.1 - 6.1e-06 25.4 0.1 1.1e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 L-fucokinase NTP_transferase PF00483.23 EFE44769.1 - 0.0007 19.2 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 EFE44769.1 - 0.015 13.5 0.2 0.021 13.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 EFE44769.1 - 0.034 14.5 0.0 0.069 13.5 0.0 1.5 1 0 0 1 1 1 0 MobA-like NTP transferase domain DUF4719 PF15843.5 EFE44772.1 - 9.4 6.3 14.9 8.1 6.5 1.8 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4719) Peptidase_S64 PF08192.11 EFE44773.1 - 8.8e-05 21.2 0.0 0.00037 19.2 0.0 1.8 2 0 0 2 2 2 1 Peptidase family S64 DUF1161 PF06649.12 EFE44773.1 - 0.2 11.9 0.0 5.9 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1161) Ribosomal_L11_N PF03946.14 EFE44775.1 - 0.00092 19.0 0.3 0.0039 17.0 0.3 2.1 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain ELO PF01151.18 EFE44776.1 - 2.1e-83 279.7 3.5 3e-83 279.2 3.5 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family Tim54 PF11711.8 EFE44776.1 - 0.0025 16.6 3.4 0.0025 16.6 3.4 2.3 2 0 0 2 2 2 1 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 EFE44776.1 - 0.016 15.4 6.5 1.1 9.4 0.1 2.3 2 0 0 2 2 2 0 DDHD domain TRAP_alpha PF03896.16 EFE44776.1 - 0.44 9.7 10.0 0.041 13.1 0.6 2.5 3 0 0 3 3 3 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 EFE44776.1 - 4.3 7.0 12.7 1.3 8.7 7.0 2.6 2 0 0 2 2 2 0 Connexin DUF913 PF06025.12 EFE44776.1 - 4.4 6.2 15.9 0.11 11.4 4.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DHHC PF01529.20 EFE44776.1 - 5.5 7.1 7.6 1e+02 3.0 0.0 3.5 3 0 0 3 3 3 0 DHHC palmitoyltransferase BUD22 PF09073.10 EFE44776.1 - 6.1 6.1 35.6 5 6.4 15.0 2.1 2 0 0 2 2 2 0 BUD22 MCM_bind PF09739.9 EFE44776.1 - 6.3 5.1 18.3 0.052 12.0 6.7 2.2 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor PBP1_TM PF14812.6 EFE44776.1 - 7.1 7.1 17.6 0.97 9.8 12.9 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Fungal_trans_2 PF11951.8 EFE44778.1 - 9.9e-06 24.6 8.1 1.5e-05 24.0 8.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Neurensin PF14927.6 EFE44778.1 - 0.0066 16.2 0.2 0.013 15.2 0.2 1.5 1 0 0 1 1 1 1 Neurensin APH PF01636.23 EFE44781.1 - 7.1e-15 55.6 0.3 2.9e-14 53.6 0.3 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE44781.1 - 4e-05 23.3 0.1 7.3e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Glyco_hydro_61 PF03443.14 EFE44783.1 - 0.023 14.6 0.1 0.059 13.3 0.1 1.7 1 1 0 1 1 1 0 Glycosyl hydrolase family 61 BNR PF02012.20 EFE44783.1 - 0.034 14.1 1.1 0.13 12.4 0.2 2.6 2 0 0 2 2 2 0 BNR/Asp-box repeat TruD PF01142.18 EFE44784.1 - 5.4e-58 196.8 0.0 3.9e-54 184.1 0.0 3.7 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Cupin_1 PF00190.22 EFE44785.1 - 1.3e-34 119.0 0.1 1.9e-16 60.0 0.0 3.1 3 0 0 3 3 3 3 Cupin Cupin_2 PF07883.11 EFE44785.1 - 2e-20 72.3 1.1 1.8e-09 37.2 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EFE44785.1 - 4.5e-06 26.3 0.1 0.01 15.5 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 EFE44785.1 - 0.00022 21.1 1.2 0.016 15.1 0.3 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain 3-HAO PF06052.12 EFE44785.1 - 0.036 13.7 0.0 0.29 10.8 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase P53_TAD PF08563.11 EFE44787.1 - 0.058 12.9 0.2 0.12 11.9 0.2 1.5 1 0 0 1 1 1 0 P53 transactivation motif RPE65 PF03055.15 EFE44788.1 - 4e-114 382.3 0.0 4.6e-114 382.2 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF2293 PF10056.9 EFE44789.1 - 5.6e-29 100.2 0.9 9.3e-29 99.5 0.3 1.7 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) FYDLN_acid PF09538.10 EFE44789.1 - 0.037 14.7 0.1 0.06 14.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF3754 PF12576.8 EFE44789.1 - 0.086 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) NUP50 PF08911.11 EFE44790.1 - 9.7 6.9 9.2 0.49 11.1 1.6 2.9 3 0 0 3 3 3 0 NUP50 (Nucleoporin 50 kDa) Mtc PF03820.17 EFE44791.1 - 5.2e-114 380.5 0.0 3.1e-113 378.0 0.0 1.8 1 1 0 1 1 1 1 Tricarboxylate carrier RNA_pol_3_Rpc31 PF11705.8 EFE44792.1 - 0.00022 21.6 3.6 0.00029 21.2 3.6 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 TFIIA PF03153.13 EFE44792.1 - 0.0063 16.6 1.7 0.0075 16.3 1.7 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF5523 PF17661.1 EFE44792.1 - 0.026 14.2 0.8 0.026 14.2 0.8 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Afi1 PF07792.12 EFE44792.1 - 0.063 13.8 5.5 0.074 13.5 1.0 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CENP-B_dimeris PF09026.10 EFE44792.1 - 0.11 12.9 13.6 0.21 12.0 13.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EFE44792.1 - 0.18 11.4 6.2 0.34 10.6 3.1 2.1 2 0 0 2 2 2 0 FAM176 family DUF3449 PF11931.8 EFE44792.1 - 2.5 7.8 7.6 0.23 11.2 2.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Pkinase PF00069.25 EFE44793.1 - 1.3e-48 165.6 0.0 7.8e-48 163.1 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44793.1 - 1.9e-19 70.0 0.0 6e-19 68.3 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase BBE PF08031.12 EFE44794.1 - 1.5e-13 50.6 0.1 5.2e-13 48.9 0.0 2.0 2 0 0 2 2 2 1 Berberine and berberine like FAD_binding_4 PF01565.23 EFE44794.1 - 1.9e-11 43.9 0.1 4.6e-11 42.6 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain CPSF73-100_C PF11718.8 EFE44795.1 - 1.6e-74 250.1 0.0 2.8e-74 249.3 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EFE44795.1 - 3.8e-31 107.6 0.0 1e-30 106.2 0.0 1.8 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EFE44795.1 - 6e-12 45.3 0.1 1.1e-11 44.5 0.1 1.4 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 EFE44795.1 - 6.4e-10 38.8 0.2 1.6e-09 37.5 0.1 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EFE44795.1 - 3.9e-09 36.8 0.0 8.9e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily TAF4 PF05236.14 EFE44796.1 - 3.3e-26 92.7 4.4 2.7e-25 89.7 4.4 2.2 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Kdo PF06293.14 EFE44797.1 - 1.2e-07 31.3 0.2 2.6e-07 30.2 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MAP7 PF05672.11 EFE44797.1 - 0.0028 17.3 34.6 0.0069 16.1 34.6 1.5 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family APH PF01636.23 EFE44797.1 - 0.036 14.0 0.1 0.036 14.0 0.1 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.25 EFE44797.1 - 0.07 12.5 0.3 0.16 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain AsmA PF05170.14 EFE44797.1 - 0.22 10.3 0.0 0.38 9.5 0.0 1.2 1 0 0 1 1 1 0 AsmA family CDC45 PF02724.14 EFE44797.1 - 0.31 9.3 7.7 0.57 8.4 7.7 1.4 1 0 0 1 1 1 0 CDC45-like protein ARGLU PF15346.6 EFE44797.1 - 0.93 9.4 36.9 2.2 8.2 36.9 1.5 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 DUF874 PF05917.11 EFE44797.1 - 2.8 6.9 14.4 4.4 6.2 14.4 1.2 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) NPR3 PF03666.13 EFE44797.1 - 6.3 5.5 8.1 13 4.4 8.1 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Asp-B-Hydro_N PF05279.11 EFE44797.1 - 6.7 6.7 14.5 13 5.7 14.5 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Peptidase_S41 PF03572.18 EFE44798.1 - 1.8e-06 27.6 0.0 1.8e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 Peptidase family S41 DUF1659 PF07872.11 EFE44798.1 - 0.036 13.7 0.2 0.084 12.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1659) Transferase PF02458.15 EFE44799.1 - 3.8e-28 98.3 0.0 7.5e-18 64.4 0.0 3.1 2 1 0 2 2 2 2 Transferase family Cyclin_N PF00134.23 EFE44803.1 - 3.4e-14 52.7 0.1 6.5e-14 51.8 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFE44803.1 - 0.0027 17.8 0.1 0.045 13.9 0.0 2.4 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 EFE44803.1 - 0.0055 16.7 2.4 0.066 13.3 0.0 2.4 2 0 0 2 2 2 1 Transcription factor TFIIB repeat EAF PF09816.9 EFE44804.1 - 3.1e-16 59.6 0.1 3.1e-16 59.6 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor SSP160 PF06933.11 EFE44804.1 - 3.5 5.7 15.3 6.6 4.8 15.3 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4811 PF16069.5 EFE44804.1 - 5.3 6.9 10.6 0.15 11.9 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4811) Dor1 PF04124.12 EFE44805.1 - 9.1e-54 182.4 3.8 7.7e-45 153.0 1.7 2.5 1 1 1 2 2 2 2 Dor1-like family Vps51 PF08700.11 EFE44805.1 - 0.023 14.8 2.2 0.039 14.0 0.5 2.3 2 0 0 2 2 2 0 Vps51/Vps67 Sec8_exocyst PF04048.14 EFE44805.1 - 0.023 14.6 0.7 0.065 13.1 0.7 1.8 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain YqfQ PF14181.6 EFE44805.1 - 0.042 14.0 2.1 2.7 8.2 0.0 3.2 3 0 0 3 3 3 0 YqfQ-like protein Snf7 PF03357.21 EFE44805.1 - 0.096 12.3 0.7 0.29 10.7 0.7 1.8 1 0 0 1 1 1 0 Snf7 Serglycin PF04360.12 EFE44805.1 - 0.42 10.6 2.3 1.2 9.1 2.1 2.0 1 1 0 1 1 1 0 Serglycin COG5 PF10392.9 EFE44805.1 - 1.3 9.2 10.7 15 5.8 4.7 3.8 3 1 0 3 3 3 0 Golgi transport complex subunit 5 His_Phos_1 PF00300.22 EFE44806.1 - 4.8e-24 85.1 0.0 1.2e-23 83.9 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 EFE44806.1 - 0.0026 17.2 0.0 0.0042 16.5 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Abhydrolase_6 PF12697.7 EFE44808.1 - 3.2e-06 27.9 0.0 4.7e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFE44808.1 - 4.2e-06 26.6 0.0 7.9e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFE44808.1 - 0.00025 20.4 0.1 0.0016 17.8 0.1 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFE44808.1 - 0.019 14.4 0.2 6.3 6.2 0.0 2.6 2 1 0 2 2 2 0 Prolyl oligopeptidase family Cyclin PF08613.11 EFE44811.1 - 3e-11 44.0 0.0 5.8e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin DUF2722 PF10846.8 EFE44811.1 - 5.8e-05 22.2 3.0 0.00011 21.3 3.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) FUSC PF04632.12 EFE44811.1 - 0.0015 17.2 0.3 0.0024 16.5 0.3 1.3 1 0 0 1 1 1 1 Fusaric acid resistance protein family TFIIA PF03153.13 EFE44811.1 - 0.0056 16.7 11.0 0.0056 16.7 11.0 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Caps_synth_GfcC PF06251.11 EFE44811.1 - 0.03 13.9 3.4 0.046 13.3 3.4 1.2 1 0 0 1 1 1 0 Capsule biosynthesis GfcC Cyclin_N PF00134.23 EFE44811.1 - 0.042 13.6 1.7 0.14 12.0 0.0 2.2 2 0 0 2 2 2 0 Cyclin, N-terminal domain Presenilin PF01080.17 EFE44811.1 - 0.11 11.2 0.3 0.14 10.9 0.3 1.2 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 EFE44811.1 - 0.28 10.9 1.8 0.47 10.2 1.8 1.3 1 0 0 1 1 1 0 Connexin Peptidase_U57 PF05582.12 EFE44811.1 - 0.58 9.4 4.1 0.88 8.8 4.1 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Peptidase_S49_N PF08496.10 EFE44811.1 - 0.64 10.1 4.6 1.1 9.3 4.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DivIC PF04977.15 EFE44811.1 - 1.3 8.8 6.3 2.8 7.8 6.3 1.5 1 0 0 1 1 1 0 Septum formation initiator DUF4407 PF14362.6 EFE44811.1 - 9.1 5.5 6.7 1.3 8.3 2.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF2052 PF09747.9 EFE44812.1 - 0.48 10.5 20.1 0.51 10.4 20.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Nop53 PF07767.11 EFE44812.1 - 0.67 9.3 30.0 0.75 9.1 30.0 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) eIF3_subunit PF08597.10 EFE44812.1 - 0.68 9.8 26.3 0.77 9.6 26.3 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit RRN3 PF05327.11 EFE44812.1 - 0.7 8.4 7.8 0.75 8.3 7.8 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RR_TM4-6 PF06459.12 EFE44812.1 - 1.5 8.6 21.6 1.7 8.4 21.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PTPRCAP PF15713.5 EFE44812.1 - 1.5 9.1 20.8 1.8 8.9 20.8 1.0 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 EFE44812.1 - 1.5 7.1 22.5 1.6 6.9 22.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.13 EFE44812.1 - 2.2 7.2 23.9 3.1 6.7 23.9 1.3 1 0 0 1 1 1 0 Paf1 MDFI PF15316.6 EFE44812.1 - 2.6 8.1 10.3 3.1 7.9 10.3 1.0 1 0 0 1 1 1 0 MyoD family inhibitor DUF3807 PF12720.7 EFE44812.1 - 4.4 7.5 21.5 5.6 7.2 21.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CobT PF06213.12 EFE44812.1 - 7.7 5.8 18.0 8.9 5.6 18.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_polI_A34 PF08208.11 EFE44812.1 - 7.7 6.5 35.9 9.3 6.3 35.9 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Rrn6 PF10214.9 EFE44812.1 - 7.9 4.8 12.5 8.5 4.7 12.5 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor ALMT PF11744.8 EFE44812.1 - 9.4 4.9 9.1 10 4.8 9.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 EFE44812.1 - 9.7 4.8 15.3 11 4.7 15.3 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFE44812.1 - 9.7 5.3 11.1 11 5.1 11.1 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CRC_subunit PF08624.10 EFE44813.1 - 7e-52 175.5 0.0 1e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit APH PF01636.23 EFE44815.1 - 0.00013 22.0 0.1 0.00062 19.8 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFE44815.1 - 0.14 11.0 0.0 0.47 9.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Beta-lactamase PF00144.24 EFE44816.1 - 3.7e-22 79.0 0.1 5.2e-22 78.5 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S58 PF03576.14 EFE44818.1 - 6.5e-92 308.2 4.1 2e-70 237.7 0.6 2.0 1 1 1 2 2 2 2 Peptidase family S58 Pkinase PF00069.25 EFE44819.1 - 2.5e-28 99.2 0.0 1.4e-27 96.7 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44819.1 - 3e-14 52.9 0.0 6.8e-14 51.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase MACPF PF01823.19 EFE44820.1 - 0.0011 19.1 0.9 0.0011 19.1 0.9 1.7 2 0 0 2 2 2 1 MAC/Perforin domain DUF1344 PF07076.11 EFE44820.1 - 0.065 13.1 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) FecR PF04773.13 EFE44820.1 - 0.19 12.4 1.9 0.4 11.3 0.3 2.3 2 1 0 2 2 2 0 FecR protein Toxin_10 PF05431.11 EFE44820.1 - 0.22 11.0 2.0 0.37 10.2 1.4 1.6 1 1 0 1 1 1 0 Insecticidal Crystal Toxin, P42 FAD_binding_4 PF01565.23 EFE44821.1 - 3.4e-21 75.5 0.0 6.2e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain p450 PF00067.22 EFE44822.1 - 4.1e-44 151.1 0.0 6.1e-44 150.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SQHop_cyclase_N PF13249.6 EFE44823.1 - 0.046 12.8 0.1 0.56 9.2 0.0 2.5 3 0 0 3 3 3 0 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EFE44823.1 - 0.052 12.6 0.3 0.5 9.4 0.0 2.6 3 1 0 3 3 3 0 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 EFE44823.1 - 0.37 10.6 3.5 7.6 6.4 0.0 3.1 3 0 0 3 3 3 0 Prenyltransferase and squalene oxidase repeat p450 PF00067.22 EFE44824.1 - 2.1e-32 112.5 0.0 3.6e-16 59.0 0.1 2.0 1 1 1 2 2 2 2 Cytochrome P450 p450 PF00067.22 EFE44825.1 - 1.8e-40 139.1 0.0 2.6e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Na_Ca_ex PF01699.24 EFE44826.1 - 2.1e-33 115.4 38.2 5.3e-17 62.2 18.7 2.0 2 0 0 2 2 2 2 Sodium/calcium exchanger protein p450 PF00067.22 EFE44827.1 - 1.2e-26 93.5 0.0 1.2e-19 70.4 0.0 3.0 1 1 1 2 2 2 2 Cytochrome P450 DUF3176 PF11374.8 EFE44828.1 - 0.21 11.8 6.6 0.037 14.2 2.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3176) ADH_zinc_N_2 PF13602.6 EFE44829.1 - 1.3e-14 55.4 0.0 3.3e-14 54.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFE44829.1 - 2.6e-08 33.7 0.0 4.5e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFE44829.1 - 1.6e-07 31.3 0.0 1.7e-06 28.1 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DIOX_N PF14226.6 EFE44830.1 - 3e-24 86.0 0.0 6e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFE44830.1 - 4.9e-10 39.8 0.1 9.2e-10 38.9 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Asp_Glu_race PF01177.22 EFE44831.1 - 4.4e-15 56.1 0.1 7.8e-15 55.3 0.1 1.4 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase AroM PF07302.11 EFE44831.1 - 0.0017 17.8 0.1 0.17 11.3 0.1 2.1 1 1 1 2 2 2 2 AroM protein Pantoate_transf PF02548.15 EFE44831.1 - 0.015 14.7 0.4 1.2 8.5 0.0 2.1 1 1 0 2 2 2 0 Ketopantoate hydroxymethyltransferase ZNRF_3_ecto PF18212.1 EFE44831.1 - 0.16 11.9 0.0 12 5.9 0.0 2.3 2 0 0 2 2 2 0 ZNRF-3 Ectodomain MFS_1 PF07690.16 EFE44832.1 - 9.1e-39 133.4 24.9 1.5e-33 116.2 17.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EFE44832.1 - 2.7e-05 22.7 9.4 0.00079 17.8 5.9 2.8 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 EFE44832.1 - 0.00013 20.9 2.0 0.00013 20.9 2.0 2.2 1 1 1 2 2 2 2 MFS_1 like family PTR2 PF00854.21 EFE44832.1 - 0.00063 18.7 8.4 0.042 12.7 0.0 3.2 2 2 1 3 3 3 3 POT family DIOX_N PF14226.6 EFE44834.1 - 6.9e-21 75.2 0.0 1.1e-20 74.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFE44834.1 - 5.4e-14 52.5 0.0 9.9e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ketoacyl-synt PF00109.26 EFE44835.1 - 3.5e-74 249.6 0.0 6.1e-74 248.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EFE44835.1 - 6.4e-46 157.0 1.2 1.4e-42 146.1 0.1 2.9 2 1 0 2 2 2 2 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EFE44835.1 - 1.5e-35 123.2 1.0 1.1e-34 120.4 0.0 2.8 3 1 1 4 4 4 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFE44835.1 - 1.6e-33 115.2 0.4 1.6e-33 115.2 0.4 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EFE44835.1 - 1.5e-14 54.1 0.1 4.1e-14 52.7 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EFE44835.1 - 2.6e-11 44.0 0.0 1.1e-10 41.9 0.0 2.1 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 EFE44835.1 - 5.2e-08 32.5 0.0 9e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EFE44835.1 - 0.00046 19.6 0.0 0.0011 18.3 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Trp_DMAT PF11991.8 EFE44836.1 - 8.1e-80 268.9 0.0 1e-79 268.7 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Orexin PF02072.15 EFE44836.1 - 0.0033 17.4 0.0 0.0058 16.6 0.0 1.3 1 0 0 1 1 1 1 Prepro-orexin FAD_binding_3 PF01494.19 EFE44837.1 - 1.6e-11 44.1 1.7 1.2e-05 24.8 0.2 2.8 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.24 EFE44837.1 - 0.0019 17.8 0.2 0.019 14.6 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE44837.1 - 0.0021 18.3 0.0 0.0045 17.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFE44837.1 - 0.028 13.7 0.2 0.29 10.3 0.0 2.1 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EFE44837.1 - 0.11 12.5 0.0 0.38 10.8 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 EFE44837.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DUF871 PF05913.11 EFE44837.1 - 0.24 10.6 0.0 0.38 9.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF871) Lactamase_B PF00753.27 EFE44838.1 - 4.7e-15 56.1 2.4 2.1e-12 47.5 2.4 2.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 EFE44838.1 - 0.00028 20.8 0.0 0.0017 18.3 0.0 2.3 3 0 0 3 3 3 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 EFE44838.1 - 0.0029 17.1 0.0 0.0049 16.4 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Fungal_trans PF04082.18 EFE44839.1 - 3.6e-08 32.8 0.0 5.8e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFE44839.1 - 1.3e-07 31.6 7.1 2.5e-07 30.7 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cep3 PF16846.5 EFE44839.1 - 0.033 12.7 0.0 0.064 11.7 0.0 1.4 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B Metallophos PF00149.28 EFE44840.1 - 1.6e-05 25.5 4.9 3e-05 24.6 4.9 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Tyrosinase PF00264.20 EFE44841.1 - 1.2e-49 169.6 3.3 1.2e-49 169.6 3.3 2.1 2 0 0 2 2 2 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EFE44841.1 - 3.4e-20 72.9 0.0 6.6e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain Fungal_trans PF04082.18 EFE44842.1 - 5.2e-21 74.9 1.4 7.8e-21 74.3 1.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_S8e PF01201.22 EFE44843.1 - 3.3e-45 153.6 2.4 4.9e-45 153.1 2.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e RIBIOP_C PF04950.12 EFE44843.1 - 0.18 11.2 6.2 0.41 10.0 6.2 1.7 1 1 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Ribosomal_L21p PF00829.21 EFE44844.1 - 1.1e-08 35.2 0.0 1.7e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein RIB43A PF05914.12 EFE44844.1 - 0.078 11.7 1.0 0.14 10.9 1.0 1.3 1 0 0 1 1 1 0 RIB43A CutA1 PF03091.15 EFE44844.1 - 0.085 12.7 0.3 0.2 11.6 0.3 1.5 1 0 0 1 1 1 0 CutA1 divalent ion tolerance protein Pkinase PF00069.25 EFE44845.1 - 7.1e-49 166.5 0.0 1.1e-48 166.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44845.1 - 5.6e-18 65.2 0.0 8.7e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EFE44845.1 - 0.0003 20.4 0.2 0.00084 19.0 0.1 1.8 1 1 1 2 2 2 1 RIO1 family APH PF01636.23 EFE44845.1 - 0.00052 20.0 0.0 0.31 10.9 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EFE44845.1 - 0.011 15.1 0.1 0.019 14.3 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4648 PF15505.6 EFE44845.1 - 0.041 14.8 2.2 11 7.0 0.0 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4648) Kinase-like PF14531.6 EFE44845.1 - 0.063 12.6 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like PWI PF01480.17 EFE44846.1 - 1.6e-27 95.6 0.1 2.9e-27 94.8 0.1 1.5 1 0 0 1 1 1 1 PWI domain Auts2 PF15336.6 EFE44846.1 - 0.071 13.2 1.4 0.14 12.2 1.4 1.4 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein DUF3042 PF11240.8 EFE44847.1 - 1.1 9.3 3.8 0.56 10.3 1.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) FAA_hydrolase PF01557.18 EFE44848.1 - 3.7e-53 180.4 0.0 5.1e-53 180.0 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family SF-assemblin PF06705.11 EFE44849.1 - 0.0055 16.1 3.6 0.01 15.2 3.6 1.4 1 0 0 1 1 1 1 SF-assemblin/beta giardin Nup54_57_C PF18570.1 EFE44849.1 - 0.024 14.2 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain Herpes_UL6 PF01763.16 EFE44849.1 - 0.039 12.5 2.7 0.054 12.0 2.7 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like SUIM_assoc PF16619.5 EFE44849.1 - 0.067 13.3 1.5 0.19 11.8 1.5 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Baculo_PEP_C PF04513.12 EFE44849.1 - 0.073 13.1 1.6 0.18 11.9 1.2 1.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LINES_N PF14694.6 EFE44849.1 - 0.15 11.5 0.2 0.23 10.9 0.2 1.3 1 0 0 1 1 1 0 Lines N-terminus MIF4G_like_2 PF09090.11 EFE44849.1 - 0.21 11.1 2.9 0.3 10.5 2.9 1.2 1 0 0 1 1 1 0 MIF4G like MscS_porin PF12795.7 EFE44849.1 - 0.24 10.9 14.5 0.097 12.2 2.1 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Androgen_recep PF02166.16 EFE44849.1 - 0.31 9.8 3.5 0.43 9.4 3.5 1.1 1 0 0 1 1 1 0 Androgen receptor Siah-Interact_N PF09032.11 EFE44849.1 - 0.58 10.5 5.9 8.8 6.7 0.0 3.3 3 0 0 3 3 3 0 Siah interacting protein, N terminal JIP_LZII PF16471.5 EFE44849.1 - 0.67 10.2 4.9 0.68 10.1 1.7 2.6 2 1 0 2 2 1 0 JNK-interacting protein leucine zipper II DUF883 PF05957.13 EFE44849.1 - 0.91 10.2 5.3 0.9 10.2 1.9 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DEAD PF00270.29 EFE44850.1 - 1e-44 152.4 0.7 2e-44 151.5 0.7 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE44850.1 - 1.4e-31 109.1 0.1 5.2e-31 107.3 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE44850.1 - 8.9e-07 29.1 0.0 1.7e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFE44850.1 - 7.7e-05 22.5 0.1 0.00015 21.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFE44850.1 - 0.0005 20.4 0.3 0.0039 17.5 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFE44850.1 - 0.005 17.1 0.3 0.023 15.0 0.3 2.1 1 1 0 1 1 1 1 AAA domain CMS1 PF14617.6 EFE44850.1 - 0.013 14.8 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 EFE44850.1 - 0.033 14.1 0.1 0.18 11.6 0.0 2.0 2 0 0 2 2 2 0 Helicase fragilysinNterm PF16376.5 EFE44850.1 - 0.075 12.8 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of fragilysin Pkinase PF00069.25 EFE44851.1 - 1.9e-49 168.4 0.0 2.9e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44851.1 - 6.7e-27 94.4 0.0 9.6e-27 93.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFE44851.1 - 0.013 14.9 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFE44851.1 - 0.029 13.7 0.0 0.046 13.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.25 EFE44852.1 - 8.5e-57 192.5 0.0 5.8e-51 173.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44852.1 - 4e-35 121.3 0.0 2.7e-33 115.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFE44852.1 - 8.3e-09 35.2 0.0 4.2e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFE44852.1 - 0.002 18.1 0.0 0.0042 17.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFE44852.1 - 0.0053 15.6 0.0 0.011 14.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF2263 PF10021.9 EFE44853.1 - 0.0065 16.8 0.0 0.02 15.3 0.0 1.8 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Methyltransf_23 PF13489.6 EFE44854.1 - 1.2e-11 44.8 0.0 3.2e-11 43.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE44854.1 - 2.7e-08 34.4 0.0 5.6e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE44854.1 - 2.8e-07 30.5 0.0 5.2e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE44854.1 - 7e-06 26.7 0.0 2.4e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE44854.1 - 0.00098 19.7 0.0 0.0019 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFE44854.1 - 0.0026 17.3 0.0 0.012 15.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 EFE44854.1 - 0.0034 17.5 0.0 0.05 13.7 0.0 2.2 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EFE44854.1 - 0.0099 15.2 0.0 0.021 14.1 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_4 PF02390.17 EFE44854.1 - 0.011 15.2 0.0 0.028 13.9 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase DUF938 PF06080.12 EFE44854.1 - 0.068 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) AAA_28 PF13521.6 EFE44854.1 - 0.13 12.5 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain NADHdh-2_N PF12155.8 EFE44854.1 - 0.16 12.3 0.2 0.44 11.0 0.1 1.8 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 N-terminal Scramblase PF03803.15 EFE44855.1 - 9.5e-50 168.9 0.0 2.3e-46 157.9 0.0 3.6 2 1 0 2 2 2 2 Scramblase Ribosomal_L27 PF01016.19 EFE44856.1 - 9.8e-32 108.8 1.0 1.8e-31 108.0 1.0 1.5 1 0 0 1 1 1 1 Ribosomal L27 protein Tudor_3 PF18115.1 EFE44857.1 - 2e-16 59.6 0.0 4.1e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain Rad9_Rad53_bind PF08605.10 EFE44857.1 - 2.2e-16 60.2 0.0 4.1e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.26 EFE44857.1 - 7e-08 32.7 0.0 4.7e-07 30.1 0.0 2.4 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFE44857.1 - 1.4e-06 28.6 0.0 3.1e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EFE44857.1 - 7.1e-05 22.6 0.0 0.00038 20.3 0.0 2.2 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EFE44857.1 - 0.1 12.6 0.0 0.31 11.1 0.0 1.8 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain BBP1_N PF15271.6 EFE44857.1 - 2 9.2 5.6 7 7.4 5.6 2.0 1 0 0 1 1 1 0 Spindle pole body component BBP1, Mps2-binding protein Anillin_N PF16018.5 EFE44857.1 - 5.9 7.6 14.2 4.2 8.0 0.1 5.0 5 0 0 5 5 5 0 Anillin N-terminus tRNA_int_endo PF01974.17 EFE44858.1 - 1.8e-17 63.2 0.3 4.8e-17 61.8 0.3 1.7 1 1 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EFE44858.1 - 0.00046 19.8 0.0 0.013 15.1 0.0 2.3 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain MscS_TM PF12794.7 EFE44858.1 - 4.1 6.2 4.2 6.6 5.5 4.2 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 NOB1_Zn_bind PF08772.11 EFE44859.1 - 8.1e-33 112.4 3.2 1.7e-32 111.4 3.2 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EFE44859.1 - 6.9e-30 103.4 1.6 2e-29 101.9 0.1 2.5 4 0 0 4 4 4 1 PIN domain of ribonuclease HypA PF01155.19 EFE44859.1 - 0.0043 17.1 0.2 0.18 11.9 0.2 2.5 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-NADH-PPase PF09297.11 EFE44859.1 - 0.028 14.1 3.1 0.034 13.8 0.4 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Cript PF10235.9 EFE44859.1 - 0.18 12.4 1.6 0.31 11.6 0.4 2.1 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT SWIRM-assoc_2 PF16496.5 EFE44859.1 - 0.2 10.5 6.8 0.26 10.1 6.1 1.5 2 0 0 2 2 2 0 SWIRM-associated domain at the N-terminal Zn-ribbon_8 PF09723.10 EFE44859.1 - 0.74 10.0 5.8 0.28 11.4 1.3 2.3 2 0 0 2 2 2 0 Zinc ribbon domain Peptidase_M18 PF02127.15 EFE44860.1 - 1.7e-133 445.6 0.0 2e-133 445.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) ABC_tran PF00005.27 EFE44861.1 - 1e-50 171.8 0.0 1.4e-25 90.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EFE44861.1 - 3.3e-25 88.9 37.5 1.4e-13 50.7 24.2 2.7 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 EFE44861.1 - 4.3e-23 82.6 0.8 0.00011 22.1 0.0 4.4 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFE44861.1 - 5.7e-10 38.8 0.9 6.9e-05 22.5 0.4 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EFE44861.1 - 5.9e-10 39.0 0.6 0.00024 20.6 0.2 3.8 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFE44861.1 - 2.1e-08 34.9 2.1 0.0057 17.2 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_27 PF13514.6 EFE44861.1 - 4.7e-06 26.3 0.4 0.073 12.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EFE44861.1 - 7.7e-06 25.9 0.1 0.058 13.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 EFE44861.1 - 3.9e-05 23.5 0.0 0.027 14.2 0.1 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_30 PF13604.6 EFE44861.1 - 0.00047 19.9 0.1 0.4 10.4 0.1 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFE44861.1 - 0.00065 20.1 0.0 1.1 9.6 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain DUF4162 PF13732.6 EFE44861.1 - 0.0017 19.1 0.0 0.064 14.0 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4162) SbcCD_C PF13558.6 EFE44861.1 - 0.0038 17.4 0.3 8 6.8 0.1 4.2 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.6 EFE44861.1 - 0.02 15.1 0.1 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFE44861.1 - 0.038 13.5 0.2 6 6.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EFE44861.1 - 0.045 13.4 0.4 8.4 6.0 0.2 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EFE44861.1 - 0.062 13.4 0.5 4.2 7.5 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EFE44861.1 - 0.078 12.2 0.1 11 5.3 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin Ploopntkinase1 PF18748.1 EFE44861.1 - 0.15 11.6 0.0 7.9 6.0 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 AAA_22 PF13401.6 EFE44861.1 - 0.2 11.9 0.2 25 5.1 0.1 2.7 2 0 0 2 2 2 0 AAA domain MukB PF04310.12 EFE44861.1 - 0.2 11.4 0.8 15 5.3 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal AAA_13 PF13166.6 EFE44861.1 - 0.26 9.9 0.5 5.4 5.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain MFS_1 PF07690.16 EFE44862.1 - 2.6e-19 69.3 4.3 4.7e-19 68.5 4.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EFE44862.1 - 0.00043 19.7 0.4 0.00061 19.2 0.4 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB NdhL PF10716.9 EFE44862.1 - 0.11 12.5 0.5 0.31 11.0 0.0 2.0 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit ABC2_membrane PF01061.24 EFE44863.1 - 4.9e-78 261.4 49.9 1.9e-40 138.6 28.1 3.3 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EFE44863.1 - 2.7e-34 118.6 0.0 1e-16 61.7 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFE44863.1 - 1.3e-23 82.7 6.3 3.7e-20 71.6 0.0 3.2 3 0 0 3 3 2 2 CDR ABC transporter AAA_21 PF13304.6 EFE44863.1 - 1.2e-05 25.3 0.0 0.16 11.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 EFE44863.1 - 3.7e-05 23.9 0.2 0.0015 18.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EFE44863.1 - 6.2e-05 23.4 0.1 0.0085 16.5 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EFE44863.1 - 0.00019 22.0 0.0 0.0038 17.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFE44863.1 - 0.00099 19.1 0.0 0.0022 17.9 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 EFE44863.1 - 0.0022 17.6 0.1 0.016 14.8 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFE44863.1 - 0.0024 17.6 0.4 0.015 15.0 0.1 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EFE44863.1 - 0.0038 17.5 0.0 0.12 12.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain ABC_trans_N PF14510.6 EFE44863.1 - 0.012 16.2 0.2 0.25 12.0 0.2 3.0 2 0 0 2 2 2 0 ABC-transporter N-terminal SMC_N PF02463.19 EFE44863.1 - 0.015 14.7 0.1 0.74 9.2 0.0 2.6 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 EFE44863.1 - 0.032 13.3 57.4 0.0077 15.4 7.0 4.6 3 1 1 4 4 4 0 ABC-2 family transporter protein AAA_17 PF13207.6 EFE44863.1 - 0.059 13.8 0.1 0.31 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EFE44863.1 - 0.078 12.6 0.4 0.17 11.4 0.4 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EFE44863.1 - 0.12 12.7 0.2 0.41 10.9 0.2 2.0 1 1 0 1 1 1 0 AAA domain PRK PF00485.18 EFE44863.1 - 0.19 11.4 0.1 25 4.5 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_23 PF13476.6 EFE44863.1 - 0.37 11.3 0.0 0.37 11.3 0.0 2.3 3 0 0 3 3 2 0 AAA domain Adap_comp_sub PF00928.21 EFE44864.1 - 1.6e-83 280.1 0.0 2.3e-83 279.6 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFE44864.1 - 1e-07 32.0 0.3 1.7e-07 31.3 0.3 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribonucleas_3_3 PF14622.6 EFE44865.1 - 1.6e-15 57.4 0.0 1.8e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EFE44865.1 - 0.00084 19.9 0.0 0.0011 19.5 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease III domain AAA_lid_7 PF17867.1 EFE44865.1 - 0.11 12.7 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Midasin AAA lid domain Sdh_cyt PF01127.22 EFE44867.1 - 3e-24 85.4 4.1 4e-24 85.0 4.1 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit NMO PF03060.15 EFE44868.1 - 9.4e-37 127.1 0.3 2e-36 126.1 0.3 1.5 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EFE44868.1 - 8.6e-06 25.0 0.5 1.9e-05 23.8 0.4 1.4 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EFE44868.1 - 0.0009 18.4 0.1 0.0014 17.7 0.1 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.14 EFE44868.1 - 0.011 15.0 0.1 0.033 13.4 0.0 1.8 1 1 1 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase SCP1201-deam PF14428.6 EFE44869.1 - 0.0045 16.9 1.9 0.0068 16.3 0.2 2.1 2 0 0 2 2 2 1 SCP1.201-like deaminase Hydrophobin PF01185.18 EFE44870.1 - 3.2e-07 30.9 10.2 4.4e-07 30.4 10.2 1.2 1 0 0 1 1 1 1 Fungal hydrophobin WW PF00397.26 EFE44871.1 - 3.6e-10 39.8 2.0 3.6e-10 39.8 2.0 2.2 2 0 0 2 2 2 1 WW domain WRW PF10206.9 EFE44871.1 - 0.083 13.3 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f Ank_2 PF12796.7 EFE44872.1 - 5.8e-13 49.2 0.8 6.6e-12 45.9 0.7 2.4 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFE44872.1 - 5e-11 42.5 0.4 8.3e-07 29.2 0.2 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFE44872.1 - 7.2e-10 38.9 1.8 2.4e-07 30.9 0.4 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFE44872.1 - 3.5e-09 36.1 0.3 6.4e-06 26.1 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EFE44872.1 - 1.8e-08 34.7 0.1 8.3e-08 32.6 0.1 2.2 2 1 0 2 2 2 1 Ankyrin repeats (many copies) UPF0128 PF03673.13 EFE44872.1 - 0.074 12.5 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) Glyco_transf_21 PF13506.6 EFE44873.1 - 1.1e-13 51.0 0.0 5.5e-07 29.2 0.0 3.3 1 1 1 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EFE44873.1 - 2.5e-07 30.8 0.0 5.3e-07 29.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 E1-E2_ATPase PF00122.20 EFE44874.1 - 1.8e-38 131.9 5.6 1e-37 129.4 0.9 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFE44874.1 - 6.8e-30 104.1 16.4 9e-30 103.7 4.5 3.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFE44874.1 - 1.4e-14 54.9 0.1 3.9e-09 37.1 0.0 3.2 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE44874.1 - 1.1e-11 44.7 0.1 2.7e-11 43.4 0.1 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFE44874.1 - 7.8e-11 41.5 0.0 1.9e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus DUF2157 PF09925.9 EFE44874.1 - 9.6e-06 25.5 7.9 0.0015 18.3 0.1 3.2 3 1 0 3 3 3 2 Predicted membrane protein (DUF2157) Hydrolase_3 PF08282.12 EFE44874.1 - 1.3e-05 25.1 0.2 3e-05 23.9 0.2 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase TMEM43 PF07787.12 EFE44874.1 - 0.0059 16.0 3.1 1.7 8.0 0.1 2.5 2 0 0 2 2 2 2 Transmembrane protein 43 PGG PF13962.6 EFE44874.1 - 0.47 10.3 7.4 0.2 11.5 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF3262 PF11660.8 EFE44874.1 - 9.6 6.7 9.3 34 4.9 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) Sigma_reg_N PF13800.6 EFE44874.1 - 9.8 6.5 6.1 1.8 8.9 0.5 2.7 3 0 0 3 3 3 0 Sigma factor regulator N-terminal HAT_KAT11 PF08214.11 EFE44875.1 - 2.7e-94 316.3 0.0 3.4e-94 316.0 0.0 1.1 1 0 0 1 1 1 1 Histone acetylation protein Cupin_2 PF07883.11 EFE44876.1 - 4.4e-07 29.5 0.1 7e-07 28.9 0.1 1.3 1 0 0 1 1 1 1 Cupin domain MannoseP_isomer PF01050.18 EFE44876.1 - 0.057 13.3 0.0 0.078 12.9 0.0 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Hid1 PF12722.7 EFE44878.1 - 0 1079.1 0.0 0 1074.2 0.0 2.0 1 1 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EFE44878.1 - 1.4e-96 324.3 0.0 1.8e-96 324.0 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein BC10 PF06726.12 EFE44878.1 - 0.1 12.8 0.8 0.31 11.3 0.1 2.2 2 0 0 2 2 2 0 Bladder cancer-related protein BC10 HTH_ABP1_N PF18107.1 EFE44879.1 - 0.94 9.2 5.1 0.19 11.5 1.0 1.9 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain Vps54 PF07928.12 EFE44882.1 - 1.8e-50 170.9 0.1 1.3e-49 168.1 0.0 2.5 2 0 0 2 2 2 1 Vps54-like protein DUF2451 PF10474.9 EFE44882.1 - 1.5e-07 31.4 0.1 6.3e-07 29.4 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 EFE44882.1 - 2.1e-05 24.0 0.2 7.2e-05 22.2 0.2 1.9 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Cytochrom_B562 PF07361.11 EFE44882.1 - 0.072 13.7 0.3 0.26 12.0 0.3 2.0 1 0 0 1 1 1 0 Cytochrome b562 DUF4363 PF14276.6 EFE44882.1 - 0.16 12.1 0.3 1.6 8.8 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) Pkinase PF00069.25 EFE44883.1 - 1.4e-21 77.1 0.0 7.2e-21 74.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE44883.1 - 7.5e-09 35.3 0.0 0.0031 16.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE44883.1 - 0.032 13.0 0.0 0.045 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EFE44883.1 - 0.082 12.8 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family U3_snoRNA_assoc PF08297.11 EFE44885.1 - 6.7e-12 46.0 0.1 6.7e-12 46.0 0.1 4.5 3 1 0 3 3 3 1 U3 snoRNA associated CTK3 PF12243.8 EFE44886.1 - 4.8e-49 165.5 0.1 6.7e-49 165.0 0.1 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 EFE44886.1 - 1.1e-20 73.5 12.7 1.3e-20 73.3 11.2 1.9 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus DUF4240 PF14024.6 EFE44886.1 - 0.03 14.5 0.5 0.95 9.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4240) CARD PF00619.21 EFE44886.1 - 0.1 12.7 0.3 0.4 10.8 0.1 2.1 2 1 0 3 3 3 0 Caspase recruitment domain P5CR_dimer PF14748.6 EFE44887.1 - 1.6e-31 108.6 3.3 2.8e-31 107.8 3.3 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EFE44887.1 - 1.4e-08 35.2 0.0 6.8e-08 33.0 0.0 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Voltage_CLC PF00654.20 EFE44888.1 - 6.4e-73 246.0 28.7 1.9e-67 228.0 18.4 2.4 2 1 1 3 3 3 2 Voltage gated chloride channel CBS PF00571.28 EFE44888.1 - 0.11 12.9 0.1 1.4 9.5 0.0 2.4 2 0 0 2 2 2 0 CBS domain AAA_5 PF07728.14 EFE44889.1 - 9.1e-137 450.1 0.0 3.2e-24 85.5 0.0 10.0 10 1 0 10 10 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EFE44889.1 - 1.7e-51 172.9 5.0 1.2e-19 70.4 0.0 5.6 5 0 0 5 5 5 4 Midasin AAA lid domain AAA_7 PF12775.7 EFE44889.1 - 5.6e-33 114.0 0.1 1.7e-05 24.4 0.0 7.3 7 0 0 7 7 7 6 P-loop containing dynein motor region AAA PF00004.29 EFE44889.1 - 8.9e-33 113.5 0.0 5.6e-05 23.6 0.0 6.7 6 0 0 6 6 6 6 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 EFE44889.1 - 6.5e-32 110.2 0.0 1.1e-10 41.5 0.0 7.5 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFE44889.1 - 1.3e-30 107.0 12.9 9.2e-05 22.9 0.3 8.2 6 2 0 6 6 6 6 AAA ATPase domain AAA_lid_5 PF17865.1 EFE44889.1 - 1.6e-30 105.3 0.4 9.1e-30 102.9 0.0 2.6 3 0 0 3 3 1 1 Midasin AAA lid domain Dynein_heavy PF03028.15 EFE44889.1 - 3e-22 79.0 0.0 1.4e-05 25.1 0.0 8.0 7 1 0 7 7 7 4 Dynein heavy chain region D6 P-loop domain AAA_6 PF12774.7 EFE44889.1 - 8.5e-22 77.5 0.0 0.0017 17.4 0.0 9.3 10 2 1 11 11 9 3 Hydrolytic ATP binding site of dynein motor region Sigma54_activat PF00158.26 EFE44889.1 - 3.1e-21 75.8 0.0 0.0089 15.7 0.0 6.6 6 0 0 6 6 6 5 Sigma-54 interaction domain AAA_22 PF13401.6 EFE44889.1 - 1.9e-19 70.3 4.3 0.033 14.5 0.1 7.9 7 1 0 7 7 6 4 AAA domain TsaE PF02367.17 EFE44889.1 - 2e-18 66.6 0.6 0.046 13.7 0.0 6.4 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EFE44889.1 - 2.1e-17 63.5 0.3 0.022 14.5 0.0 7.9 6 2 0 6 6 6 3 AAA domain AAA_18 PF13238.6 EFE44889.1 - 3.6e-17 63.1 0.0 0.16 12.5 0.0 6.8 6 0 0 6 6 6 3 AAA domain Mg_chelatase PF01078.21 EFE44889.1 - 1.8e-16 60.1 7.8 0.34 10.3 0.0 9.4 8 2 0 9 9 9 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFE44889.1 - 2.4e-16 60.2 0.0 0.12 12.5 0.0 6.9 6 1 0 6 6 6 3 AAA domain ABC_tran PF00005.27 EFE44889.1 - 1e-15 58.4 1.9 0.014 16.0 0.0 6.5 6 0 0 6 6 6 3 ABC transporter AAA_14 PF13173.6 EFE44889.1 - 2.3e-15 56.8 0.0 0.00059 19.9 0.0 7.5 7 0 0 7 7 7 2 AAA domain RuvB_N PF05496.12 EFE44889.1 - 1.8e-14 53.8 2.2 0.11 12.2 0.0 6.8 7 0 0 7 7 7 4 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EFE44889.1 - 2.8e-13 50.1 7.6 0.071 13.0 0.1 7.4 7 0 0 7 7 7 2 NACHT domain RNA_helicase PF00910.22 EFE44889.1 - 9.6e-13 48.5 0.5 0.77 10.2 0.0 6.5 6 0 0 6 6 6 1 RNA helicase Sigma54_activ_2 PF14532.6 EFE44889.1 - 2e-12 47.4 0.4 0.02 15.0 0.0 6.4 6 0 0 6 6 6 2 Sigma-54 interaction domain DUF815 PF05673.13 EFE44889.1 - 7.3e-12 45.0 1.7 0.4 9.8 0.2 6.2 6 0 0 6 6 6 2 Protein of unknown function (DUF815) Rad17 PF03215.15 EFE44889.1 - 1.2e-11 44.9 0.8 0.031 14.2 0.0 6.2 6 0 0 6 6 6 1 Rad17 P-loop domain AAA_19 PF13245.6 EFE44889.1 - 4.3e-11 43.3 7.0 1.8 8.9 0.1 7.2 6 2 0 6 6 6 3 AAA domain IstB_IS21 PF01695.17 EFE44889.1 - 6.3e-11 42.3 0.0 1.1 9.0 0.0 6.4 6 0 0 6 6 6 1 IstB-like ATP binding protein AAA_2 PF07724.14 EFE44889.1 - 1.4e-10 41.6 0.0 0.33 11.1 0.0 6.3 6 0 0 6 6 6 2 AAA domain (Cdc48 subfamily) SRP54 PF00448.22 EFE44889.1 - 2e-10 40.6 2.8 0.54 9.8 0.1 6.0 6 0 0 6 6 6 2 SRP54-type protein, GTPase domain AAA_29 PF13555.6 EFE44889.1 - 3.8e-10 39.4 0.2 1.7 8.5 0.0 6.5 6 0 0 6 6 6 1 P-loop containing region of AAA domain PduV-EutP PF10662.9 EFE44889.1 - 7.4e-10 38.7 1.1 0.15 11.8 0.0 6.3 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation T2SSE PF00437.20 EFE44889.1 - 9e-10 38.0 0.2 0.036 13.1 0.0 5.5 6 0 0 6 6 5 1 Type II/IV secretion system protein AAA_25 PF13481.6 EFE44889.1 - 9.2e-10 38.4 2.3 1.3 8.6 0.0 6.3 7 0 0 7 7 6 2 AAA domain Zeta_toxin PF06414.12 EFE44889.1 - 1.2e-09 37.7 9.6 0.012 14.9 0.0 7.5 8 0 0 8 8 8 1 Zeta toxin AAA_28 PF13521.6 EFE44889.1 - 2.5e-09 37.6 5.3 0.25 11.6 0.0 6.2 6 0 0 6 6 6 2 AAA domain AAA_24 PF13479.6 EFE44889.1 - 3.5e-09 36.7 0.0 0.82 9.4 0.0 6.2 6 0 0 6 6 6 1 AAA domain RsgA_GTPase PF03193.16 EFE44889.1 - 7.3e-09 35.7 6.3 0.44 10.4 0.3 6.1 6 0 0 6 6 6 1 RsgA GTPase Roc PF08477.13 EFE44889.1 - 7.5e-09 35.8 1.8 5.2 7.3 0.0 6.3 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EFE44889.1 - 1.8e-08 34.0 0.0 3.7 6.9 0.0 5.9 6 0 0 6 6 6 0 Bacterial TniB protein ATPase_2 PF01637.18 EFE44889.1 - 1.8e-08 34.6 0.0 8.6 6.2 0.0 6.0 6 0 0 6 6 6 0 ATPase domain predominantly from Archaea TIP49 PF06068.13 EFE44889.1 - 3.8e-08 32.9 1.7 0.63 9.2 0.0 5.2 5 0 0 5 5 5 1 TIP49 P-loop domain MCM PF00493.23 EFE44889.1 - 1.8e-07 30.5 0.0 1.6 7.8 0.0 5.1 5 0 0 5 5 5 1 MCM P-loop domain ResIII PF04851.15 EFE44889.1 - 1e-06 28.9 0.2 1.5 8.8 0.0 5.2 5 0 0 5 5 5 2 Type III restriction enzyme, res subunit AAA_23 PF13476.6 EFE44889.1 - 2.2e-06 28.3 0.2 7.9 6.9 0.0 6.3 6 0 0 6 6 6 0 AAA domain Bac_DnaA PF00308.18 EFE44889.1 - 4e-06 26.8 0.0 2.7 7.8 0.0 4.9 5 0 0 5 5 4 0 Bacterial dnaA protein AAA_8 PF12780.7 EFE44889.1 - 1.1e-05 24.9 2.0 15 4.8 0.0 6.5 7 0 0 7 7 7 0 P-loop containing dynein motor region D4 NTPase_1 PF03266.15 EFE44889.1 - 1.6e-05 24.9 6.9 1 9.2 0.0 6.3 7 0 0 7 7 5 1 NTPase DnaB_C PF03796.15 EFE44889.1 - 2.6e-05 23.7 1.0 0.83 8.9 0.0 4.3 4 0 0 4 4 4 1 DnaB-like helicase C terminal domain AAA_11 PF13086.6 EFE44889.1 - 5.6e-05 23.1 0.6 6 6.6 0.0 5.6 6 0 0 6 6 6 0 AAA domain SRPRB PF09439.10 EFE44889.1 - 7.4e-05 22.2 1.3 9.7 5.6 0.1 5.7 6 0 0 6 6 6 0 Signal recognition particle receptor beta subunit ATPase PF06745.13 EFE44889.1 - 0.00014 21.3 0.5 6.9 5.9 0.0 4.8 6 0 0 6 6 4 0 KaiC CPT PF07931.12 EFE44889.1 - 0.0002 21.2 4.5 0.68 9.7 0.0 6.1 7 1 0 7 7 4 1 Chloramphenicol phosphotransferase-like protein Viral_helicase1 PF01443.18 EFE44889.1 - 0.00021 21.1 0.5 6.1 6.5 0.0 5.4 6 0 0 6 6 5 0 Viral (Superfamily 1) RNA helicase MMR_HSR1 PF01926.23 EFE44889.1 - 0.00021 21.4 1.5 27 4.9 0.0 6.0 6 0 0 6 6 6 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFE44889.1 - 0.00026 20.8 5.7 9.3 6.0 0.1 5.8 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein AAA_17 PF13207.6 EFE44889.1 - 0.00032 21.1 3.4 6.5 7.2 0.0 4.9 5 0 0 5 5 4 0 AAA domain NB-ARC PF00931.22 EFE44889.1 - 0.00068 18.9 2.3 12 5.0 0.0 5.1 6 0 0 6 6 4 0 NB-ARC domain PhoH PF02562.16 EFE44889.1 - 0.0015 18.0 0.5 10 5.5 0.0 4.7 5 0 0 5 5 5 0 PhoH-like protein AAA_15 PF13175.6 EFE44889.1 - 0.0027 17.5 0.0 3.5 7.3 0.0 4.1 5 0 0 5 5 4 0 AAA ATPase domain CbiA PF01656.23 EFE44889.1 - 0.0039 17.3 0.2 3.8 7.6 0.1 3.9 4 0 0 4 4 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain G-alpha PF00503.20 EFE44889.1 - 0.0041 16.3 0.9 31 3.6 0.0 4.6 5 0 0 5 5 5 0 G-protein alpha subunit PRK PF00485.18 EFE44889.1 - 0.0048 16.7 0.1 29 4.3 0.0 4.8 5 0 0 5 5 4 0 Phosphoribulokinase / Uridine kinase family GAF_2 PF13185.6 EFE44889.1 - 0.0048 17.2 0.0 0.028 14.7 0.0 2.4 1 0 0 1 1 1 1 GAF domain Ploopntkinase3 PF18751.1 EFE44889.1 - 0.011 15.7 0.2 30 4.5 0.0 4.2 4 0 0 4 4 4 0 P-loop Nucleotide Kinase3 cobW PF02492.19 EFE44889.1 - 0.011 15.4 7.4 13 5.3 0.0 5.4 6 0 0 6 6 5 0 CobW/HypB/UreG, nucleotide-binding domain ATP-synt_ab PF00006.25 EFE44889.1 - 0.047 13.3 0.0 13 5.4 0.1 3.2 3 1 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain Ras PF00071.22 EFE44889.1 - 0.053 13.1 3.0 33 4.1 0.0 4.8 5 0 0 5 5 5 0 Ras family dNK PF01712.19 EFE44889.1 - 0.066 13.1 4.3 3.4 7.5 0.0 4.0 5 0 0 5 5 3 0 Deoxynucleoside kinase IPT PF01745.16 EFE44889.1 - 0.1 12.0 1.4 46 3.3 0.0 4.4 5 0 0 5 5 4 0 Isopentenyl transferase KTI12 PF08433.10 EFE44889.1 - 0.13 11.6 0.9 42 3.5 0.0 4.0 4 0 0 4 4 4 0 Chromatin associated protein KTI12 Parvo_NS1 PF01057.17 EFE44889.1 - 0.16 11.0 0.0 18 4.3 0.0 3.4 4 0 0 4 4 4 0 Parvovirus non-structural protein NS1 TrwB_AAD_bind PF10412.9 EFE44889.1 - 0.26 10.2 0.9 53 2.6 0.0 4.1 5 0 0 5 5 4 0 Type IV secretion-system coupling protein DNA-binding domain Gtr1_RagA PF04670.12 EFE44889.1 - 0.36 10.2 2.4 44 3.3 0.0 4.2 5 0 0 5 5 4 0 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EFE44889.1 - 0.44 10.1 4.6 71 2.9 0.0 4.8 6 0 0 6 6 5 0 Ferrous iron transport protein B MobB PF03205.14 EFE44889.1 - 0.48 10.3 6.3 58 3.6 0.0 5.3 6 0 0 6 6 6 0 Molybdopterin guanine dinucleotide synthesis protein B Septin PF00735.18 EFE44889.1 - 0.8 8.9 2.5 21 4.2 0.1 4.1 6 0 0 6 6 6 0 Septin AAA_PrkA PF08298.11 EFE44889.1 - 4.5 6.1 5.1 35 3.2 0.0 3.5 5 0 0 5 5 3 0 PrkA AAA domain Aspzincin_M35 PF14521.6 EFE44890.1 - 0.0017 18.9 0.1 0.0056 17.2 0.1 1.7 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase Ala_racemase_N PF01168.20 EFE44891.1 - 8.8e-22 77.8 0.0 1.2e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Adaptin_N PF01602.20 EFE44892.1 - 1.1e-124 416.9 4.8 1.4e-124 416.6 4.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EFE44892.1 - 5.6e-41 139.3 0.0 1.3e-40 138.1 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EFE44892.1 - 9.2e-17 61.4 0.0 3.1e-16 59.7 0.0 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd1 PF12717.7 EFE44892.1 - 0.0016 18.5 0.7 0.063 13.3 0.0 2.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 EFE44892.1 - 0.0081 15.9 0.0 0.63 9.8 0.0 3.1 2 1 0 2 2 2 1 rRNA processing/ribosome biogenesis RasGEF_N_2 PF14663.6 EFE44892.1 - 3.8 7.9 4.8 19 5.7 0.0 3.3 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain efThoc1 PF11957.8 EFE44896.1 - 6.4e-139 463.8 5.4 9e-139 463.3 5.4 1.1 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Aquarius_N PF16399.5 EFE44897.1 - 2.4e-297 988.3 0.6 3.2e-286 951.6 0.1 2.1 1 1 1 2 2 2 2 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EFE44897.1 - 2.6e-25 89.2 0.0 4.7e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFE44897.1 - 3.9e-23 82.6 0.0 7.7e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFE44897.1 - 2.4e-07 30.6 0.0 7.3e-05 22.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFE44897.1 - 9.2e-07 29.3 0.0 1.9e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EFE44897.1 - 4.2e-06 26.9 0.0 9.6e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 EFE44897.1 - 0.00027 20.7 0.1 0.31 10.7 0.0 3.0 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 EFE44897.1 - 0.0012 19.2 0.6 0.005 17.2 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain UvrD-helicase PF00580.21 EFE44897.1 - 0.0016 18.1 0.5 0.0055 16.3 0.0 2.1 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA PF00004.29 EFE44897.1 - 0.0026 18.2 0.0 0.0098 16.3 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 EFE44897.1 - 0.0042 16.4 0.0 0.0092 15.3 0.0 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain DEAD PF00270.29 EFE44897.1 - 0.0055 16.5 0.0 0.11 12.2 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase PIF1 PF05970.14 EFE44897.1 - 0.0069 15.6 0.0 0.74 8.9 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase AAA_22 PF13401.6 EFE44897.1 - 0.016 15.5 2.3 0.21 11.9 0.2 3.3 2 1 1 3 3 3 0 AAA domain Adeno_IVa2 PF02456.15 EFE44897.1 - 0.019 13.8 0.0 0.042 12.6 0.0 1.5 1 0 0 1 1 1 0 Adenovirus IVa2 protein SPOUT_MTase PF02590.17 EFE44897.1 - 0.031 14.3 0.0 7.5 6.5 0.0 2.5 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase DUF2075 PF09848.9 EFE44897.1 - 0.035 13.3 0.9 0.071 12.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EFE44897.1 - 0.055 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EFE44897.1 - 0.056 13.4 0.0 0.23 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) UvrD_C_2 PF13538.6 EFE44897.1 - 0.08 12.8 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_7 PF12775.7 EFE44897.1 - 0.13 11.7 0.0 0.35 10.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Transp_cyt_pur PF02133.15 EFE44898.1 - 3.2e-87 293.1 35.3 4.6e-87 292.6 35.3 1.2 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Tfb2 PF03849.14 EFE44899.1 - 1.1e-105 353.5 0.0 1.8e-105 352.8 0.0 1.3 2 0 0 2 2 2 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EFE44899.1 - 4.5e-24 84.6 0.6 8.3e-24 83.8 0.6 1.5 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EFE44899.1 - 9.9e-06 25.7 0.0 0.00011 22.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PhzC-PhzF PF02567.16 EFE44901.1 - 2.1e-39 135.7 0.2 4.9e-39 134.5 0.2 1.5 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein TIMELESS PF04821.14 EFE44902.1 - 9.3e-50 169.4 2.0 2.4e-49 168.1 0.0 2.5 2 0 0 2 2 2 1 Timeless protein TIMELESS_C PF05029.13 EFE44902.1 - 1.6e-40 139.9 23.9 1e-37 130.6 15.9 4.1 2 1 0 2 2 2 2 Timeless protein C terminal region CSRNP_N PF16019.5 EFE44902.1 - 9.3 6.1 14.7 0.76 9.7 3.8 2.7 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus 3HCDH_N PF02737.18 EFE44903.1 - 3.3e-52 177.0 1.0 4.3e-52 176.6 1.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EFE44903.1 - 3.8e-34 117.2 0.0 8.9e-34 116.0 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EFE44903.1 - 0.00015 22.0 0.5 0.0005 20.3 0.3 2.0 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EFE44903.1 - 0.00057 19.6 0.1 0.014 15.1 0.0 2.2 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 EFE44903.1 - 0.0006 20.1 0.1 0.00097 19.4 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 EFE44903.1 - 0.01 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 EFE44903.1 - 0.013 15.1 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 EFE44903.1 - 0.025 13.8 0.0 0.034 13.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 EFE44903.1 - 0.067 13.2 0.2 0.14 12.1 0.1 1.6 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 EFE44903.1 - 0.067 12.6 1.3 0.72 9.2 0.2 2.1 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EFE44903.1 - 0.11 13.1 0.2 0.25 11.9 0.1 1.7 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 EFE44903.1 - 0.37 11.4 2.5 1.6 9.3 2.2 2.2 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent IBR PF01485.21 EFE44904.1 - 7.3e-08 32.5 13.9 4.5e-05 23.6 9.3 2.5 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain ANAPC16 PF17256.2 EFE44904.1 - 0.9 10.0 3.8 16 5.9 0.5 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, subunit 16 zf-RING_4 PF14570.6 EFE44904.1 - 1.7 8.5 11.2 6.9 6.6 4.5 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Actin PF00022.19 EFE44905.1 - 3.9e-83 279.3 0.0 3.8e-82 276.1 0.0 1.9 1 1 0 1 1 1 1 Actin GCIP PF13324.6 EFE44906.1 - 3e-26 92.6 4.4 3e-26 92.6 4.4 1.3 2 0 0 2 2 2 1 Grap2 and cyclin-D-interacting Sigma70_ner PF04546.13 EFE44906.1 - 0.0042 17.0 1.6 0.006 16.5 1.6 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region LRR_8 PF13855.6 EFE44907.1 - 9e-33 111.8 39.6 2.4e-09 36.8 2.5 8.2 7 1 1 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 EFE44907.1 - 8e-25 86.5 53.7 7.2e-06 26.3 0.5 11.0 7 4 5 13 13 13 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFE44907.1 - 1.2e-06 28.2 35.0 0.72 10.6 0.0 12.8 12 2 0 12 12 12 1 Leucine Rich Repeat LRR_9 PF14580.6 EFE44907.1 - 0.00073 19.1 19.6 0.16 11.4 0.9 4.7 3 2 1 4 4 4 4 Leucine-rich repeat GrpE PF01025.19 EFE44909.1 - 0.032 13.9 6.7 1.4 8.6 0.3 2.3 2 0 0 2 2 2 0 GrpE TMF_TATA_bd PF12325.8 EFE44909.1 - 0.055 13.7 9.3 0.11 12.8 9.3 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Mto2_bdg PF12808.7 EFE44909.1 - 0.13 12.5 6.0 0.074 13.4 1.2 2.6 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Ribosomal_L13e PF01294.18 EFE44910.1 - 2.1e-75 252.5 4.3 3.3e-75 251.9 4.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e BAF1_ABF1 PF04684.13 EFE44910.1 - 0.096 11.7 1.3 0.13 11.3 1.3 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Asp-B-Hydro_N PF05279.11 EFE44911.1 - 0.53 10.3 3.8 1.1 9.2 3.8 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4635 PF15466.6 EFE44911.1 - 2.6 7.6 5.2 16 5.0 1.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) DUF4404 PF14357.6 EFE44911.1 - 4.5 8.0 6.1 8 7.2 2.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Oxidored-like PF09791.9 EFE44912.1 - 8e-24 83.0 4.4 8e-24 83.0 4.4 2.2 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal DUF5522 PF17653.1 EFE44912.1 - 7.4 6.6 11.0 0.23 11.4 3.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5522) KAP PF05804.12 EFE44913.1 - 0.0029 15.8 0.1 0.0065 14.7 0.0 1.5 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) Pribosyltran PF00156.27 EFE44915.1 - 0.00067 19.2 0.1 0.011 15.3 0.0 2.1 2 0 0 2 2 2 2 Phosphoribosyl transferase domain SR-25 PF10500.9 EFE44916.1 - 1.5e-05 24.7 17.2 1.8e-05 24.5 17.2 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein RNA_polI_A34 PF08208.11 EFE44916.1 - 0.0024 18.0 10.4 0.0032 17.6 10.4 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 DUF4604 PF15377.6 EFE44916.1 - 0.0079 16.6 13.5 0.0097 16.4 13.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) DUF3767 PF12597.8 EFE44916.1 - 0.19 11.6 1.9 0.35 10.7 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) Presenilin PF01080.17 EFE44916.1 - 1.5 7.5 6.9 1.8 7.3 6.9 1.0 1 0 0 1 1 1 0 Presenilin SHR3_chaperone PF08229.11 EFE44916.1 - 2 7.4 7.2 0.37 9.8 3.5 1.6 1 1 1 2 2 2 0 ER membrane protein SH3 HSF_DNA-bind PF00447.17 EFE44917.1 - 2.7e-30 104.8 1.0 1.1e-29 102.8 0.5 2.0 2 0 0 2 2 2 1 HSF-type DNA-binding GCD14_N PF14801.6 EFE44917.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit N-term GCOM2 PF15328.6 EFE44917.1 - 0.24 11.8 1.3 6.9 7.0 1.8 2.4 2 0 0 2 2 2 0 Putative GRINL1B complex locus protein 2 GREB1 PF15782.5 EFE44917.1 - 0.47 7.5 6.7 0.79 6.8 6.7 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 EFE44918.1 - 0.095 12.7 1.2 3.4 7.7 0.4 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Plasmodium_Vir PF05795.11 EFE44918.1 - 1.7 8.0 4.0 1.5 8.2 1.2 1.9 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF3245 PF11595.8 EFE44919.1 - 2.6e-41 141.5 5.0 3.4e-41 141.2 5.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3245) ATP-grasp_2 PF08442.10 EFE44920.1 - 1.4e-77 259.8 0.3 2.4e-77 259.1 0.3 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EFE44920.1 - 6.2e-25 87.8 0.8 1.9e-24 86.2 0.3 2.0 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 EFE44920.1 - 4.6e-09 36.0 0.4 9.6e-09 35.0 0.1 1.6 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 EFE44920.1 - 0.00011 22.0 0.8 0.029 14.1 0.1 2.6 2 1 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Succ_CoA_lig PF13607.6 EFE44920.1 - 0.013 15.3 0.3 2.1 8.1 0.1 2.6 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain VID27_N PF17748.1 EFE44920.1 - 0.15 11.9 0.8 0.27 11.1 0.8 1.3 1 0 0 1 1 1 0 VID27 N-terminal region adh_short PF00106.25 EFE44921.1 - 5.3e-10 39.1 0.0 5.9e-10 38.9 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE44921.1 - 5.3e-07 29.4 0.0 5.9e-07 29.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EFE44921.1 - 0.027 14.4 0.0 0.033 14.1 0.0 1.1 1 0 0 1 1 1 0 NAD(P)H-binding NmrA PF05368.13 EFE44921.1 - 0.066 12.8 0.0 0.076 12.6 0.0 1.0 1 0 0 1 1 1 0 NmrA-like family Beta-lactamase PF00144.24 EFE44922.1 - 6e-33 114.5 0.0 1.2e-31 110.2 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 EFE44922.1 - 0.0024 17.5 0.0 2.3 7.8 0.0 2.3 2 0 0 2 2 2 2 Beta-lactamase enzyme family Peptidase_S11 PF00768.20 EFE44922.1 - 0.13 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Peptidase_S8 PF00082.22 EFE44923.1 - 1.8e-22 80.0 16.2 3.4e-22 79.1 15.6 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE44923.1 - 1.4e-18 67.4 0.0 2.2e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 SLAC1 PF03595.17 EFE44924.1 - 1e-83 281.3 53.7 1.2e-83 281.1 53.7 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel TraP PF07296.11 EFE44924.1 - 0.34 10.1 1.7 0.48 9.6 0.2 1.8 2 0 0 2 2 2 0 TraP protein CAAD PF14159.6 EFE44924.1 - 1.5 8.7 6.1 0.28 11.0 0.2 2.8 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase ABC1 PF03109.16 EFE44925.1 - 6.8e-21 74.7 0.0 2.1e-18 66.6 0.0 2.5 1 1 0 1 1 1 1 ABC1 family RIO1 PF01163.22 EFE44925.1 - 0.05 13.2 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Raf1_HTH PF18579.1 EFE44925.1 - 0.16 11.7 0.0 0.4 10.4 0.0 1.7 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain HA2 PF04408.23 EFE44926.1 - 3.1e-15 56.4 0.1 6e-13 49.0 0.0 2.6 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFE44926.1 - 5.6e-07 29.9 0.0 1.6e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 EFE44926.1 - 0.0035 17.7 0.1 0.0085 16.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFE44926.1 - 0.012 15.9 0.0 0.062 13.6 0.0 2.1 1 1 1 2 2 2 0 AAA domain DEAD PF00270.29 EFE44926.1 - 0.04 13.7 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase T2SSE PF00437.20 EFE44926.1 - 0.073 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 EFE44926.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 EFE44926.1 - 0.18 11.3 0.1 0.38 10.2 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region SSB PF00436.25 EFE44927.1 - 1.2e-13 51.0 0.0 1.7e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family STE3 PF02076.15 EFE44928.1 - 3.1e-80 269.5 13.2 3.8e-80 269.2 13.2 1.1 1 0 0 1 1 1 1 Pheromone A receptor Bestrophin PF01062.21 EFE44928.1 - 0.038 13.4 1.6 0.092 12.1 1.6 1.6 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel Pex24p PF06398.11 EFE44928.1 - 0.042 12.8 3.7 0.069 12.1 3.7 1.4 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin MscS_TM PF12794.7 EFE44928.1 - 0.062 12.2 0.7 0.091 11.6 0.7 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF4131 PF13567.6 EFE44928.1 - 1.2 8.7 5.1 0.39 10.4 1.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF4472 PF14739.6 EFE44929.1 - 0.0047 17.6 1.0 0.012 16.4 1.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4472) RT_RNaseH PF17917.1 EFE44929.1 - 0.015 15.5 0.2 10 6.5 0.0 3.3 3 1 0 3 3 3 0 RNase H-like domain found in reverse transcriptase Imm17 PF15562.6 EFE44929.1 - 0.015 15.1 0.2 0.032 14.1 0.2 1.5 1 0 0 1 1 1 0 Immunity protein 17 FlaC_arch PF05377.11 EFE44929.1 - 0.12 12.8 0.6 0.29 11.6 0.2 1.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Exo_endo_phos PF03372.23 EFE44930.1 - 2.3e-08 33.9 0.0 4.1e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DCP1 PF06058.13 EFE44931.1 - 3.4e-28 97.9 0.0 5.6e-28 97.2 0.0 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family DUF1299 PF06975.11 EFE44931.1 - 0.0089 16.1 0.7 0.018 15.1 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1299) LIDHydrolase PF10230.9 EFE44932.1 - 5.2e-35 121.3 0.0 6.4e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EFE44932.1 - 0.00023 20.5 0.1 0.00046 19.5 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EFE44932.1 - 0.0028 17.8 0.0 0.0048 17.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EFE44932.1 - 0.04 14.5 0.0 0.041 14.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EFE44932.1 - 0.049 13.5 0.0 0.069 13.0 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EFE44932.1 - 0.074 12.9 0.0 0.23 11.3 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 3) Abhydrolase_9 PF10081.9 EFE44932.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family DUF900 PF05990.12 EFE44932.1 - 0.17 11.4 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF3530 PF12048.8 EFE44932.1 - 0.17 11.3 0.1 0.23 10.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) SMK-1 PF04802.15 EFE44933.1 - 9.2e-77 257.2 0.3 1.9e-76 256.2 0.3 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 DUF572 PF04502.13 EFE44933.1 - 0.091 12.4 14.1 0.14 11.7 14.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Nop14 PF04147.12 EFE44933.1 - 1.6 6.9 14.3 2.6 6.2 14.3 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EFE44933.1 - 3.3 5.9 13.0 4.8 5.3 13.0 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2207 PF09972.9 EFE44934.1 - 0.27 10.0 14.5 59 2.2 14.5 2.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) NPR3 PF03666.13 EFE44934.1 - 1.3 7.8 5.3 1.7 7.3 5.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC35F PF06027.12 EFE44935.1 - 1.1e-97 327.2 23.0 1.2e-97 327.0 23.0 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EFE44935.1 - 3.8e-10 39.2 0.9 5.8e-10 38.6 0.9 1.4 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EFE44935.1 - 9.3e-10 38.8 39.3 3.9e-05 23.9 16.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family FUSC-like PF12805.7 EFE44935.1 - 0.018 14.1 0.9 0.018 14.1 0.9 2.4 3 1 0 3 3 3 0 FUSC-like inner membrane protein yccS Roughex PF06020.11 EFE44937.1 - 0.17 11.0 8.1 0.33 10.0 8.1 1.4 1 0 0 1 1 1 0 Drosophila roughex protein DUF4604 PF15377.6 EFE44938.1 - 0.93 9.9 25.8 1.5 9.3 25.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) MCM_bind PF09739.9 EFE44938.1 - 1.6 7.1 15.3 2.2 6.6 15.3 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PAP_assoc PF03828.19 EFE44940.1 - 4.3e-17 62.1 0.1 1e-16 60.9 0.1 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EFE44940.1 - 0.0026 18.0 0.0 0.0052 17.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain SE PF08491.10 EFE44941.1 - 3.9e-73 245.9 0.0 5e-73 245.5 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EFE44941.1 - 3.1e-11 43.1 0.0 6e-10 38.9 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EFE44941.1 - 2.3e-09 37.3 0.3 5e-06 26.3 0.3 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFE44941.1 - 3.7e-07 29.6 1.5 3.5e-05 23.1 1.6 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EFE44941.1 - 0.00014 21.2 0.2 0.00033 20.0 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFE44941.1 - 0.0002 21.5 0.6 0.00043 20.4 0.6 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFE44941.1 - 0.00029 20.3 0.9 0.00043 19.8 0.9 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EFE44941.1 - 0.00034 19.8 0.2 0.0013 17.9 0.1 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 EFE44941.1 - 0.00037 19.8 0.0 0.00074 18.8 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EFE44941.1 - 0.00066 18.8 0.4 0.0011 18.1 0.4 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 EFE44941.1 - 0.00073 18.3 0.7 0.0021 16.8 0.2 1.9 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox PF00070.27 EFE44941.1 - 0.0019 18.7 0.2 0.014 15.9 0.2 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EFE44941.1 - 0.0051 16.5 0.4 0.019 14.6 0.3 1.9 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EFE44941.1 - 0.0051 16.9 0.0 0.0086 16.1 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Trp_halogenase PF04820.14 EFE44941.1 - 0.011 14.6 0.2 0.097 11.5 0.2 2.0 2 0 0 2 2 2 0 Tryptophan halogenase GMC_oxred_N PF00732.19 EFE44941.1 - 0.056 12.8 0.2 9.1 5.6 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase Pyr_redox_3 PF13738.6 EFE44941.1 - 0.13 11.5 0.2 0.38 10.0 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PPR PF01535.20 EFE44942.1 - 1.1e-06 28.5 0.6 0.12 12.7 0.0 5.6 5 0 0 5 5 5 1 PPR repeat PPR_2 PF13041.6 EFE44942.1 - 0.0062 16.7 0.1 2.6 8.3 0.0 4.2 5 0 0 5 5 5 1 PPR repeat family PPR_1 PF12854.7 EFE44942.1 - 0.0069 16.1 0.0 9 6.1 0.0 3.5 3 0 0 3 3 3 2 PPR repeat TPR_14 PF13428.6 EFE44942.1 - 0.012 16.4 0.4 1.9 9.6 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFE44942.1 - 0.02 15.4 0.1 10 6.7 0.0 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFE44942.1 - 0.066 13.4 0.7 1.1e+02 3.3 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat MFS_1 PF07690.16 EFE44943.1 - 2.4e-26 92.5 14.7 2.1e-18 66.4 5.6 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF2269 PF10027.9 EFE44943.1 - 1.2 9.2 7.4 0.88 9.6 3.4 2.4 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2269) Ferrochelatase PF00762.19 EFE44944.1 - 5.3e-72 242.6 0.0 6e-72 242.4 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase MP PF01107.18 EFE44944.1 - 0.19 11.3 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 Viral movement protein (MP) Ku PF02735.16 EFE44945.1 - 1e-44 152.7 0.0 2.7e-44 151.3 0.0 1.7 2 0 0 2 2 2 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EFE44945.1 - 9e-32 110.6 0.0 1.3e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EFE44945.1 - 1.8e-24 86.3 3.9 5e-24 84.8 3.9 1.9 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 EFE44945.1 - 1.8e-13 49.9 0.0 3.6e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 EFE44945.1 - 0.00037 20.1 0.2 0.00078 19.1 0.2 1.6 1 0 0 1 1 1 1 HeH/LEM domain Adap_comp_sub PF00928.21 EFE44946.1 - 8.6e-83 277.7 0.0 1.1e-82 277.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFE44946.1 - 0.00027 20.9 0.2 0.00045 20.2 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Erf4 PF10256.9 EFE44947.1 - 6.1e-41 139.2 0.0 9.8e-41 138.5 0.0 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family zf-C2H2_4 PF13894.6 EFE44949.1 - 2.7e-05 24.6 6.3 0.13 13.2 1.9 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE44949.1 - 4.9e-05 23.6 9.6 0.023 15.1 0.2 2.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE44949.1 - 0.00053 20.3 3.8 0.046 14.2 0.2 2.6 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_2 PF12756.7 EFE44949.1 - 0.0026 18.0 2.4 0.047 14.0 0.8 2.1 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 EFE44949.1 - 0.015 15.0 1.6 0.015 15.0 1.6 1.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-met PF12874.7 EFE44949.1 - 0.036 14.5 1.9 0.097 13.1 1.9 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EFE44949.1 - 0.091 12.8 0.8 0.091 12.8 0.8 3.2 3 2 0 3 3 3 0 C2H2-type zinc finger Cyto_heme_lyase PF01265.17 EFE44950.1 - 1.2e-119 399.2 0.5 1.4e-119 399.0 0.5 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase APH PF01636.23 EFE44951.1 - 6.3e-05 23.0 0.1 0.00012 22.0 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family RNase_PH PF01138.21 EFE44952.1 - 2.1e-24 86.5 0.0 3.9e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Lactamase_B PF00753.27 EFE44953.1 - 4.4e-10 39.9 0.1 9e-10 38.9 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFE44953.1 - 0.00033 20.2 0.0 0.00058 19.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain GST_N_3 PF13417.6 EFE44954.1 - 0.16 12.4 0.6 0.42 11.1 0.1 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain MFS_1 PF07690.16 EFE44955.1 - 7.9e-31 107.2 33.6 4.7e-29 101.4 29.3 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE44955.1 - 7.4e-08 31.7 8.6 7.4e-08 31.7 8.6 2.6 1 1 1 2 2 2 1 Sugar (and other) transporter ProRS-C_1 PF09180.11 EFE44956.1 - 1e-19 70.5 4.7 2.2e-19 69.4 4.7 1.5 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EFE44956.1 - 1e-17 64.7 0.0 1.7e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFE44956.1 - 1.7e-12 47.3 0.0 4.3e-12 46.0 0.0 1.7 2 0 0 2 2 2 1 Anticodon binding domain Cpn60_TCP1 PF00118.24 EFE44957.1 - 1.7e-138 462.3 16.4 1.9e-138 462.2 16.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.32 EFE44958.1 - 5.7e-14 52.3 8.8 0.00039 21.2 0.1 5.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE44958.1 - 1.6e-07 31.5 0.0 0.0014 18.8 0.0 4.4 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain DUF3378 PF11858.8 EFE44958.1 - 0.21 11.7 0.0 0.5 10.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3378) S1 PF00575.23 EFE44959.1 - 1.2e-68 227.5 39.7 2.1e-15 56.8 0.4 11.4 11 0 0 11 11 11 10 S1 RNA binding domain TPR_19 PF14559.6 EFE44959.1 - 0.00013 22.4 0.0 0.0091 16.5 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat RNase_II_C_S1 PF18614.1 EFE44959.1 - 0.00032 20.6 1.4 1.6 8.7 0.0 5.4 5 0 0 5 5 5 1 RNase II-type exonuclease C-terminal S1 domain TPR_14 PF13428.6 EFE44959.1 - 0.0053 17.5 0.0 0.53 11.3 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Suf PF05843.14 EFE44959.1 - 0.0064 16.5 13.5 0.06 13.3 0.0 4.6 2 2 1 4 4 3 2 Suppressor of forked protein (Suf) NRDE-2 PF08424.10 EFE44959.1 - 0.01 15.0 0.0 0.045 12.9 0.0 1.9 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference PCB_OB PF17092.5 EFE44959.1 - 0.055 14.2 14.5 2.6 8.8 0.0 6.3 6 1 0 6 6 5 0 Penicillin-binding protein OB-like domain PPR PF01535.20 EFE44959.1 - 0.099 12.9 0.0 31 5.1 0.0 3.2 2 1 0 2 2 2 0 PPR repeat Cue1_U7BR PF18499.1 EFE44959.1 - 0.11 12.5 1.4 0.17 12.0 0.0 2.1 2 0 0 2 2 1 0 Ubc7p-binding region of Cue1 TPR_16 PF13432.6 EFE44959.1 - 0.13 12.9 0.0 24 5.7 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat S1_2 PF13509.6 EFE44959.1 - 0.37 10.9 4.9 26 5.0 0.0 5.7 8 0 0 8 8 8 0 S1 domain Phage_lysozyme PF00959.19 EFE44961.1 - 2.8e-11 43.8 0.0 5.7e-11 42.8 0.0 1.5 2 0 0 2 2 2 1 Phage lysozyme UreD PF01774.17 EFE44962.1 - 4.2e-79 265.4 0.0 5e-79 265.1 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein STAG PF08514.11 EFE44963.1 - 6.8e-40 135.5 1.5 6.8e-40 135.5 1.5 3.6 3 0 0 3 3 3 1 STAG domain HEAT_2 PF13646.6 EFE44963.1 - 0.0044 17.4 0.0 0.23 11.9 0.2 3.3 1 1 1 2 2 2 1 HEAT repeats YL1 PF05764.13 EFE44963.1 - 0.0044 17.2 21.1 0.0044 17.2 21.1 4.8 4 1 0 5 5 5 1 YL1 nuclear protein Allexi_40kDa PF05549.11 EFE44963.1 - 5.6 6.4 12.6 0.2 11.2 0.1 3.7 2 2 1 4 4 4 0 Allexivirus 40kDa protein GFA PF04828.14 EFE44964.1 - 9e-11 42.0 0.1 1.5e-10 41.3 0.1 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Defensin_big PF14862.6 EFE44964.1 - 0.35 11.2 2.0 15 6.0 0.1 2.4 2 0 0 2 2 2 0 Big defensin Acatn PF13000.7 EFE44965.1 - 1.7e-155 518.7 16.8 2.2e-82 277.4 8.6 3.2 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 CENP-O PF09496.10 EFE44966.1 - 9.2e-64 215.3 0.0 1.4e-63 214.8 0.0 1.2 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component DUF3504 PF12012.8 EFE44968.1 - 0.023 14.6 1.5 0.048 13.6 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) DFP PF04127.15 EFE44970.1 - 1.4e-12 47.8 0.0 7.2e-05 22.7 0.0 3.2 2 1 1 3 3 3 3 DNA / pantothenate metabolism flavoprotein Polysacc_deac_1 PF01522.21 EFE44971.1 - 1.8e-12 47.3 0.0 3.3e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EFE44971.1 - 0.011 15.5 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) DEAD PF00270.29 EFE44972.1 - 3.5e-42 144.1 0.0 5.9e-42 143.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFE44972.1 - 3e-27 95.2 0.0 9.9e-26 90.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFE44972.1 - 0.031 14.3 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit UTP25 PF06862.12 EFE44972.1 - 0.035 12.9 0.0 3.4 6.3 0.0 2.4 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Glyoxal_oxid_N PF07250.11 EFE44973.1 - 1.9e-37 128.8 0.0 9.1e-37 126.5 0.0 2.2 3 0 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EFE44973.1 - 3.2e-25 88.2 0.4 6.1e-25 87.4 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Chitin_bind_1 PF00187.19 EFE44973.1 - 9.3e-07 29.2 19.7 9.3e-07 29.2 19.7 2.5 2 0 0 2 2 2 1 Chitin recognition protein Kelch_6 PF13964.6 EFE44973.1 - 0.001 19.3 0.4 23 5.5 0.0 5.5 6 0 0 6 6 6 1 Kelch motif PQQ_2 PF13360.6 EFE44973.1 - 0.091 12.3 0.0 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 PQQ-like domain Fumble PF03630.14 EFE44974.1 - 1.5e-142 474.6 1.0 1.9e-142 474.3 1.0 1.1 1 0 0 1 1 1 1 Fumble GPI2 PF06432.11 EFE44975.1 - 2.1e-129 430.9 6.2 2.6e-129 430.6 6.2 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Macoilin PF09726.9 EFE44976.1 - 0.014 14.0 8.8 0.017 13.7 8.8 1.0 1 0 0 1 1 1 0 Macoilin family UPF0239 PF06783.11 EFE44976.1 - 0.22 11.8 0.1 0.22 11.8 0.1 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0239) AIF_C PF14721.6 EFE44976.1 - 0.42 11.0 5.8 7.4 6.9 3.7 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Spt5_N PF11942.8 EFE44976.1 - 1.2 10.1 13.8 0.19 12.7 8.1 2.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Podoplanin PF05808.11 EFE44976.1 - 2.9 8.0 4.8 1 9.4 1.6 1.8 2 0 0 2 2 2 0 Podoplanin Hid1 PF12722.7 EFE44976.1 - 8.3 4.4 10.2 9.9 4.1 10.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Glyco_hydro_18 PF00704.28 EFE44978.1 - 4.6e-22 79.1 0.4 2e-21 77.1 0.4 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 SLATT_5 PF18160.1 EFE44979.1 - 0.73 9.1 3.0 0.78 9.0 0.5 2.3 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 Bunya_G2 PF03563.13 EFE44979.1 - 5.1 6.3 6.6 9.1 5.4 6.6 1.4 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 AA_permease_2 PF13520.6 EFE44980.1 - 1.5e-38 132.7 58.0 1.2e-37 129.8 58.0 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE44980.1 - 7.8e-16 57.7 52.0 1.1e-13 50.6 52.0 2.0 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFE44982.1 - 6.4e-46 157.0 46.4 8.3e-46 156.7 46.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE44982.1 - 1.4e-28 99.7 41.7 1.9e-28 99.3 41.7 1.0 1 0 0 1 1 1 1 Amino acid permease Dynamin_N PF00350.23 EFE44983.1 - 1.3e-26 93.7 0.0 3.3e-26 92.4 0.0 1.8 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFE44983.1 - 7.6e-08 31.9 1.1 0.013 14.7 0.0 3.2 3 1 0 3 3 3 2 Dynamin central region MMR_HSR1 PF01926.23 EFE44983.1 - 0.0007 19.7 0.0 0.0032 17.5 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase APG17 PF04108.12 EFE44983.1 - 0.0086 15.2 1.4 0.017 14.2 1.4 1.4 1 0 0 1 1 1 1 Autophagy protein Apg17 GTP_EFTU PF00009.27 EFE44983.1 - 0.11 12.0 0.2 1.4 8.4 0.0 2.7 4 0 0 4 4 4 0 Elongation factor Tu GTP binding domain GED PF02212.18 EFE44983.1 - 0.22 11.7 4.4 1 9.6 0.1 3.7 4 0 0 4 4 4 0 Dynamin GTPase effector domain DUF2254 PF10011.9 EFE44984.1 - 0.051 12.4 1.2 0.072 11.9 1.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) HemY_N PF07219.13 EFE44984.1 - 0.11 12.7 1.2 0.21 11.8 1.2 1.5 1 0 0 1 1 1 0 HemY protein N-terminus 5_nucleotid_C PF02872.18 EFE44987.1 - 2.4e-33 115.6 0.0 1.6e-31 109.6 0.0 2.5 1 1 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EFE44987.1 - 0.0032 18.0 0.4 0.0056 17.2 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5385 PF17359.2 EFE44988.1 - 0.011 15.3 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) TMEM154 PF15102.6 EFE44988.1 - 0.044 13.7 0.0 0.046 13.6 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family DUF5305 PF17231.2 EFE44988.1 - 0.063 12.7 0.0 0.078 12.4 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Chordopox_A13L PF05961.11 EFE44988.1 - 0.065 13.5 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A13L protein DUF5367 PF17329.2 EFE44988.1 - 0.068 13.3 0.0 0.094 12.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5367) Kinetochor_Ybp2 PF08568.10 EFE44988.1 - 0.13 10.8 0.0 0.15 10.5 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family, YAP/Alf4/glomulin DUF2371 PF10177.9 EFE44988.1 - 0.18 12.0 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) Aldedh PF00171.22 EFE44989.1 - 3.4e-147 490.7 0.1 4.3e-147 490.4 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Nha1_C PF08619.10 EFE44992.1 - 0.042 13.1 7.5 0.052 12.8 7.5 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Gln-synt_C PF00120.24 EFE44994.1 - 4.5e-63 213.3 0.0 1.1e-62 212.0 0.0 1.6 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 EFE44994.1 - 6.4e-14 52.4 0.0 1.1e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase MFS_1 PF07690.16 EFE44995.1 - 1.2e-34 119.9 25.2 1.2e-34 119.9 25.2 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFE44995.1 - 7.6e-14 51.4 10.8 7.6e-14 51.4 10.8 2.7 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EFE44995.1 - 0.0013 17.2 3.7 0.0021 16.5 3.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFA1_2 PF17317.2 EFE44995.1 - 0.2 11.5 0.7 0.46 10.3 0.0 2.0 2 0 0 2 2 2 0 Mating hormone A-factor 1&2 UPF0016 PF01169.19 EFE44998.1 - 4.3e-39 132.7 26.4 1.2e-19 70.4 7.5 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF2070 PF09843.9 EFE44998.1 - 0.0073 14.6 0.2 0.012 13.9 0.2 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) Mntp PF02659.15 EFE44998.1 - 0.018 14.8 0.1 0.018 14.8 0.1 2.3 2 0 0 2 2 2 0 Putative manganese efflux pump DUF3357 PF11837.8 EFE44998.1 - 7.8 7.0 8.8 88 3.6 0.1 4.3 4 1 0 4 4 4 0 Domain of unknown function (DUF3357) APH PF01636.23 EFE44999.1 - 1.9e-13 50.9 0.1 1.6e-12 47.9 0.1 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFE44999.1 - 0.0003 20.5 0.0 0.00048 19.8 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EFE44999.1 - 0.0044 16.6 0.0 0.19 11.3 0.0 2.1 2 0 0 2 2 2 1 RIO1 family Fanconi_A_N PF15865.5 EFE44999.1 - 0.19 11.1 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Fanconi anaemia group A protein N terminus Myb_DNA-binding PF00249.31 EFE45000.1 - 0.00012 22.2 0.3 0.00031 20.9 0.3 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain TRF PF08558.10 EFE45000.1 - 0.003 17.2 0.0 0.0046 16.6 0.0 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Annexin PF00191.20 EFE45001.1 - 8.9e-14 51.3 6.0 0.00083 19.4 0.1 4.6 4 1 0 4 4 4 4 Annexin Ribosomal_L21e PF01157.18 EFE45002.1 - 7e-30 102.9 5.0 7e-30 102.9 5.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e DUF5486 PF17588.2 EFE45002.1 - 0.22 11.4 3.0 0.93 9.4 0.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5486) S4 PF01479.25 EFE45003.1 - 6.6e-12 44.9 1.3 6.6e-12 44.9 1.3 2.4 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 EFE45003.1 - 3.8e-05 24.5 0.0 6.6e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain DUF3103 PF11301.8 EFE45004.1 - 0.037 12.8 0.1 0.037 12.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3103) DUF1664 PF07889.12 EFE45004.1 - 0.09 12.8 3.4 0.11 12.6 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Bacillus_HBL PF05791.11 EFE45004.1 - 0.17 11.7 2.5 0.19 11.6 0.3 2.1 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF1216 PF06746.11 EFE45004.1 - 0.18 11.8 6.5 0.047 13.7 2.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1216) DUF948 PF06103.11 EFE45004.1 - 0.61 10.4 2.5 5.3 7.4 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 EFE45004.1 - 0.66 10.3 12.9 0.16 12.3 4.7 3.3 3 1 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Kre28 PF17097.5 EFE45004.1 - 0.81 8.6 11.4 5 6.0 11.4 2.2 1 1 0 1 1 1 0 Spindle pole body component MPS2 PF17060.5 EFE45004.1 - 1.1 8.4 5.9 3.5 6.8 5.9 1.8 1 1 0 1 1 1 0 Monopolar spindle protein 2 HIP1_clath_bdg PF16515.5 EFE45004.1 - 1.8 9.2 23.8 0.16 12.6 6.4 3.2 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fez1 PF06818.15 EFE45004.1 - 2.3 8.7 16.9 6 7.3 16.9 1.7 1 1 0 1 1 1 0 Fez1 Spc7 PF08317.11 EFE45004.1 - 2.3 7.0 22.1 1.1 8.1 11.9 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Prefoldin PF02996.17 EFE45004.1 - 2.4 8.1 13.3 3.3 7.6 0.2 3.6 2 1 2 4 4 4 0 Prefoldin subunit Alb1 PF09135.11 EFE45004.1 - 3.3 8.6 8.7 0.49 11.3 4.2 1.9 2 0 0 2 2 1 0 Alb1 DivIC PF04977.15 EFE45004.1 - 4.6 7.1 20.8 3.4 7.5 0.1 3.8 4 1 0 4 4 4 0 Septum formation initiator CC2-LZ PF16516.5 EFE45004.1 - 4.6 7.7 13.6 4.2 7.8 1.8 3.0 2 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator SlyX PF04102.12 EFE45004.1 - 7 7.3 15.3 6.9 7.4 1.4 3.7 2 1 1 3 3 3 0 SlyX DUF16 PF01519.16 EFE45004.1 - 8.4 6.9 12.5 42 4.7 4.9 3.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Baculo_PEP_C PF04513.12 EFE45004.1 - 8.7 6.4 8.7 3.2e+02 1.3 8.8 2.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Atg14 PF10186.9 EFE45004.1 - 9.7 5.2 14.1 3.1e+02 0.2 14.2 2.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlaC_arch PF05377.11 EFE45004.1 - 9.7 6.7 10.6 21 5.6 0.0 3.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Amidoligase_2 PF12224.8 EFE45006.1 - 4.7e-05 23.2 0.0 0.29 10.8 0.0 2.6 3 0 0 3 3 3 2 Putative amidoligase enzyme Vps62 PF06101.11 EFE45008.1 - 0.02 13.2 0.2 3.7 5.7 0.0 2.3 2 0 0 2 2 2 0 Vacuolar protein sorting-associated protein 62 BSP_II PF05432.11 EFE45009.1 - 0.066 12.9 15.8 0.07 12.8 15.8 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) NOA36 PF06524.12 EFE45009.1 - 0.082 12.2 10.5 0.086 12.2 10.5 1.0 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 EFE45009.1 - 0.4 10.7 7.7 0.42 10.6 7.7 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2207 PF09972.9 EFE45009.1 - 0.49 9.1 2.4 0.54 9.0 2.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Pox_Ag35 PF03286.14 EFE45009.1 - 0.63 9.8 12.8 0.74 9.6 12.8 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Sporozoite_P67 PF05642.11 EFE45009.1 - 0.97 7.4 8.7 0.99 7.4 8.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Afi1 PF07792.12 EFE45009.1 - 1.4 9.4 6.6 1.7 9.1 6.6 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TFB6 PF17110.5 EFE45009.1 - 1.5 8.6 6.4 1.5 8.5 6.4 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF3824 PF12868.7 EFE45009.1 - 1.6 9.4 9.1 1.9 9.2 9.1 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) DUF2457 PF10446.9 EFE45009.1 - 1.8 7.6 18.5 2.1 7.4 18.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RPN2_C PF18004.1 EFE45009.1 - 2.6 7.9 13.2 3 7.8 13.2 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DNA_pol_phi PF04931.13 EFE45009.1 - 2.7 6.0 16.6 2.8 5.9 16.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi RNA_pol_3_Rpc31 PF11705.8 EFE45009.1 - 3.1 8.0 18.9 3.6 7.8 18.9 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.14 EFE45009.1 - 3.7 5.7 12.4 3.6 5.8 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 EFE45009.1 - 4.4 6.6 15.4 4.7 6.6 15.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TRAP_alpha PF03896.16 EFE45009.1 - 4.8 6.3 7.6 4.9 6.3 7.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CENP-B_dimeris PF09026.10 EFE45009.1 - 5.7 7.4 12.6 7.8 7.0 12.6 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Myc_N PF01056.18 EFE45009.1 - 8.5 6.2 12.4 9.4 6.0 12.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region DUF4820 PF16091.5 EFE45009.1 - 9.5 5.5 8.5 11 5.3 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Septin PF00735.18 EFE45010.1 - 9.3e-34 117.0 0.0 1.6e-13 50.6 0.0 3.2 3 0 0 3 3 3 3 Septin FtsK_SpoIIIE PF01580.18 EFE45010.1 - 0.056 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.6 EFE45010.1 - 0.14 12.6 2.0 0.32 11.5 0.4 2.3 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EFE45010.1 - 0.27 11.3 2.8 0.75 9.8 0.0 2.8 3 0 0 3 3 3 0 Dynamin family ATPgrasp_N PF18130.1 EFE45011.1 - 1.8e-16 60.4 0.0 4.1e-16 59.3 0.0 1.5 2 0 0 2 2 2 1 ATP-grasp N-terminal domain TMEM51 PF15345.6 EFE45012.1 - 0.012 15.5 3.8 0.017 15.0 3.8 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Asp-B-Hydro_N PF05279.11 EFE45012.1 - 0.1 12.7 8.8 0.11 12.5 8.8 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF3584 PF12128.8 EFE45012.1 - 0.91 7.0 7.9 1.1 6.6 7.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4763 PF15960.5 EFE45012.1 - 1.7 7.9 8.7 2.1 7.6 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) P5-ATPase PF12409.8 EFE45013.1 - 1.5e-41 141.4 0.1 2.8e-41 140.5 0.0 1.5 2 0 0 2 2 2 1 P5-type ATPase cation transporter Cation_ATPase_N PF00690.26 EFE45013.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EFE45014.1 - 2.9e-11 44.0 0.0 2.2e-10 41.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFE45014.1 - 0.00018 21.5 0.0 0.00032 20.7 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFE45014.1 - 0.00021 20.9 0.0 0.00033 20.2 0.0 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFE45015.1 - 0.0019 18.5 0.1 0.0027 18.0 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase G_glu_transpept PF01019.21 EFE45016.1 - 5.9e-108 361.9 0.0 1.6e-107 360.4 0.0 1.6 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase Pkinase PF00069.25 EFE45017.1 - 7.6e-12 45.2 0.0 5.6e-05 22.6 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Totivirus_coat PF05518.11 EFE45017.1 - 0.81 7.7 2.3 0.97 7.4 2.3 1.2 1 0 0 1 1 1 0 Totivirus coat protein LapA_dom PF06305.11 EFE45018.1 - 0.00095 18.9 0.1 0.0031 17.3 0.1 1.9 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain 2-Hacid_dh_C PF02826.19 EFE45019.1 - 8.4e-49 165.3 0.0 1.3e-48 164.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFE45019.1 - 2.3e-34 117.9 0.0 3.9e-34 117.2 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 EFE45019.1 - 7.7e-05 22.4 0.1 0.00021 21.0 0.0 1.8 2 0 0 2 2 2 1 ACT domain NAD_binding_2 PF03446.15 EFE45019.1 - 0.00015 22.0 0.3 0.00037 20.7 0.3 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EFE45019.1 - 0.0096 16.0 0.1 0.02 15.0 0.1 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 EFE45019.1 - 0.016 14.8 0.1 0.043 13.4 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 EFE45019.1 - 0.02 15.4 0.1 0.068 13.7 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain DUF1780 PF08682.10 EFE45019.1 - 0.051 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative endonuclease, protein of unknown function (DUF1780) 3HCDH_N PF02737.18 EFE45019.1 - 0.24 11.3 1.7 3.5 7.5 0.6 2.7 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain tRNA-synt_2b PF00587.25 EFE45020.1 - 2.1e-29 102.7 0.0 3.6e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EFE45020.1 - 1.2e-19 70.6 4.4 1.2e-19 70.6 4.4 1.9 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain DUF3698 PF12479.8 EFE45020.1 - 0.051 14.1 0.2 0.23 12.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3698) CAMSAP_CC1 PF17095.5 EFE45020.1 - 0.12 12.2 2.5 0.27 11.1 2.5 1.5 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin DUF4337 PF14235.6 EFE45020.1 - 2.1 8.5 4.3 4.1 7.5 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF1700 PF08006.11 EFE45021.1 - 3.7 7.0 6.4 5.2 6.6 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Ras PF00071.22 EFE45022.1 - 8.6e-43 145.7 0.1 9.7e-43 145.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFE45022.1 - 3.2e-13 50.0 0.0 4.6e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFE45022.1 - 9.5e-06 25.2 0.0 1e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFE45022.1 - 0.00012 21.7 0.1 0.00018 21.1 0.1 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFE45022.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase ECSCR PF15820.5 EFE45024.1 - 0.0038 17.0 3.0 0.0039 17.0 3.0 1.0 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator SP_C-Propep PF08999.10 EFE45024.1 - 0.14 12.0 6.3 0.14 12.0 6.3 1.1 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide EphA2_TM PF14575.6 EFE45024.1 - 0.4 11.6 4.0 0.5 11.3 4.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Spc7 PF08317.11 EFE45026.1 - 4.1e-05 22.6 1.4 5.4e-05 22.2 1.4 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein APG17 PF04108.12 EFE45026.1 - 9.3e-05 21.7 1.2 0.24 10.5 0.8 2.0 1 1 1 2 2 2 2 Autophagy protein Apg17 Baculo_PEP_C PF04513.12 EFE45026.1 - 0.00019 21.5 12.3 0.0016 18.5 3.8 2.1 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus LXG PF04740.12 EFE45026.1 - 0.0011 18.8 3.6 0.074 12.8 0.0 2.3 1 1 1 2 2 2 1 LXG domain of WXG superfamily EzrA PF06160.12 EFE45026.1 - 0.0013 17.0 2.1 0.0013 17.0 2.1 2.0 1 1 1 2 2 2 1 Septation ring formation regulator, EzrA Transcrip_act PF04949.13 EFE45026.1 - 0.0014 18.5 2.2 0.83 9.5 1.2 2.2 1 1 1 2 2 2 1 Transcriptional activator NPV_P10 PF05531.12 EFE45026.1 - 0.002 18.6 5.2 0.014 15.8 2.8 2.9 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 EFE45026.1 - 0.0029 18.0 6.0 3.6 8.1 0.0 3.5 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) TACC_C PF05010.14 EFE45026.1 - 0.0043 16.9 0.5 0.04 13.7 0.6 2.1 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal MAP65_ASE1 PF03999.12 EFE45026.1 - 0.0051 15.6 0.8 0.0067 15.2 0.8 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Syntaxin PF00804.25 EFE45026.1 - 0.0052 16.5 3.9 0.0069 16.1 3.1 1.5 1 1 0 1 1 1 1 Syntaxin SKA2 PF16740.5 EFE45026.1 - 0.0067 16.2 1.0 1.4 8.7 0.1 2.4 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 2 DUF4407 PF14362.6 EFE45026.1 - 0.0084 15.5 1.3 0.0084 15.5 1.3 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) Lectin_N PF03954.14 EFE45026.1 - 0.0089 15.8 1.6 0.028 14.2 0.6 2.0 1 1 1 2 2 2 1 Hepatic lectin, N-terminal domain DUF812 PF05667.11 EFE45026.1 - 0.011 14.7 1.5 0.015 14.3 1.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF16 PF01519.16 EFE45026.1 - 0.011 16.2 6.7 0.055 14.0 2.6 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 Filament PF00038.21 EFE45026.1 - 0.011 15.3 2.8 0.012 15.2 1.5 1.5 1 1 1 2 2 2 0 Intermediate filament protein Apolipoprotein PF01442.18 EFE45026.1 - 0.015 15.2 0.5 0.048 13.5 0.5 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.15 EFE45026.1 - 0.016 14.8 0.3 0.022 14.4 0.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TPR_MLP1_2 PF07926.12 EFE45026.1 - 0.018 15.1 0.4 0.042 13.9 0.3 1.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Uso1_p115_C PF04871.13 EFE45026.1 - 0.018 15.4 1.4 0.026 14.9 1.4 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF677 PF05055.12 EFE45026.1 - 0.019 13.9 2.6 0.042 12.7 2.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF677) AAA_13 PF13166.6 EFE45026.1 - 0.019 13.6 1.9 0.025 13.2 1.9 1.2 1 0 0 1 1 1 0 AAA domain IFT57 PF10498.9 EFE45026.1 - 0.023 13.7 2.1 0.031 13.2 2.1 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Nup54 PF13874.6 EFE45026.1 - 0.024 14.7 0.1 0.024 14.7 0.1 1.7 2 0 0 2 2 1 0 Nucleoporin complex subunit 54 AIP3 PF03915.13 EFE45026.1 - 0.026 13.6 2.9 0.072 12.2 2.7 1.7 1 1 0 1 1 1 0 Actin interacting protein 3 DUF3584 PF12128.8 EFE45026.1 - 0.027 12.0 2.3 0.034 11.7 2.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TelA PF05816.11 EFE45026.1 - 0.027 13.6 2.4 2.6 7.0 0.8 2.5 2 1 0 2 2 2 0 Toxic anion resistance protein (TelA) DUF1664 PF07889.12 EFE45026.1 - 0.027 14.5 5.7 0.34 11.0 1.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PspA_IM30 PF04012.12 EFE45026.1 - 0.029 14.0 1.3 4.1 6.9 0.2 2.0 1 1 1 2 2 2 0 PspA/IM30 family HsbA PF12296.8 EFE45026.1 - 0.029 14.8 0.7 0.029 14.8 0.7 2.1 2 1 0 2 2 1 0 Hydrophobic surface binding protein A SKA1 PF07160.12 EFE45026.1 - 0.032 14.1 2.5 0.12 12.2 1.8 1.8 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 CENP-F_leu_zip PF10473.9 EFE45026.1 - 0.032 14.2 3.2 0.047 13.7 3.2 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1411 PF07199.11 EFE45026.1 - 0.036 13.7 0.4 0.052 13.2 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) HIP1_clath_bdg PF16515.5 EFE45026.1 - 0.056 14.1 1.1 0.12 13.0 0.2 2.0 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1640 PF07798.11 EFE45026.1 - 0.058 13.4 4.9 0.14 12.2 4.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DUF2730 PF10805.8 EFE45026.1 - 0.059 13.5 0.6 0.14 12.3 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) DUF3450 PF11932.8 EFE45026.1 - 0.06 12.6 2.0 5.7 6.2 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) PIN_8 PF18476.1 EFE45026.1 - 0.063 13.1 1.8 0.091 12.6 1.8 1.2 1 0 0 1 1 1 0 PIN like domain Rab5-bind PF09311.11 EFE45026.1 - 0.064 12.6 2.3 0.088 12.2 2.3 1.2 1 0 0 1 1 1 0 Rabaptin-like protein PDCD7 PF16021.5 EFE45026.1 - 0.065 12.4 1.7 0.42 9.7 1.0 1.9 1 1 1 2 2 2 0 Programmed cell death protein 7 Laminin_II PF06009.12 EFE45026.1 - 0.065 13.3 5.8 0.21 11.6 1.7 2.2 1 1 1 2 2 2 0 Laminin Domain II Lebercilin PF15619.6 EFE45026.1 - 0.071 12.8 1.9 0.13 11.9 1.9 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Spectrin PF00435.21 EFE45026.1 - 0.072 13.6 2.2 5 7.7 0.5 2.9 1 1 1 2 2 2 0 Spectrin repeat DUF948 PF06103.11 EFE45026.1 - 0.073 13.3 3.5 0.36 11.1 1.2 3.0 2 1 1 3 3 2 0 Bacterial protein of unknown function (DUF948) UPF0184 PF03670.13 EFE45026.1 - 0.078 13.4 0.8 1.6 9.2 0.2 2.7 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0184) LPP PF04728.13 EFE45026.1 - 0.082 13.3 1.9 0.81 10.1 1.0 2.7 1 1 1 2 2 1 0 Lipoprotein leucine-zipper RasGAP_C PF03836.15 EFE45026.1 - 0.093 12.9 3.7 6.4 6.9 3.8 2.6 1 1 0 1 1 1 0 RasGAP C-terminus TssO PF17561.2 EFE45026.1 - 0.094 12.8 0.5 0.35 11.0 0.2 2.1 2 0 0 2 2 1 0 Type VI secretion system, TssO Plasmid_RAQPRD PF09686.10 EFE45026.1 - 0.11 12.8 0.5 0.32 11.2 0.3 1.9 2 0 0 2 2 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) YabA PF06156.13 EFE45026.1 - 0.12 13.0 0.4 2.2 8.9 0.0 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Serine_rich PF08824.10 EFE45026.1 - 0.14 12.1 0.9 0.36 10.8 0.9 1.6 1 1 0 1 1 1 0 Serine rich protein interaction domain Prefoldin_2 PF01920.20 EFE45026.1 - 0.15 12.0 3.8 6.7 6.7 2.2 2.9 2 1 0 2 2 2 0 Prefoldin subunit Fzo_mitofusin PF04799.13 EFE45026.1 - 0.16 11.5 1.3 7.2 6.1 0.5 2.4 1 1 1 2 2 2 0 fzo-like conserved region Fib_alpha PF08702.10 EFE45026.1 - 0.17 12.1 6.8 0.28 11.3 5.8 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family COG6 PF06419.11 EFE45026.1 - 0.17 10.0 2.5 0.93 7.6 2.6 1.9 1 1 0 1 1 1 0 Conserved oligomeric complex COG6 Tropomyosin_1 PF12718.7 EFE45026.1 - 0.18 11.9 2.6 1.7 8.8 0.1 2.1 1 1 1 2 2 2 0 Tropomyosin like Phage_GP20 PF06810.11 EFE45026.1 - 0.19 11.5 3.6 0.14 11.9 1.7 1.6 1 1 0 1 1 1 0 Phage minor structural protein GP20 UL42 PF17638.2 EFE45026.1 - 0.19 11.7 2.1 0.21 11.6 0.3 1.8 2 0 0 2 2 2 0 HCMV UL42 Allexi_40kDa PF05549.11 EFE45026.1 - 0.2 11.2 3.1 0.38 10.2 2.8 1.6 1 1 0 1 1 1 0 Allexivirus 40kDa protein Atg14 PF10186.9 EFE45026.1 - 0.2 10.7 2.6 0.27 10.3 2.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 EFE45026.1 - 0.2 9.6 0.8 0.26 9.2 0.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CCDC-167 PF15188.6 EFE45026.1 - 0.21 12.0 1.2 0.47 10.8 1.2 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 FliJ PF02050.16 EFE45026.1 - 0.27 11.5 0.8 3.2 8.0 0.3 2.3 1 1 2 3 3 3 0 Flagellar FliJ protein CdvA PF18822.1 EFE45026.1 - 0.28 11.0 6.1 0.96 9.3 1.2 3.2 2 1 2 4 4 4 0 CdvA-like coiled-coil domain BLOC1_2 PF10046.9 EFE45026.1 - 0.3 11.4 4.0 13 6.2 0.1 2.9 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MCPsignal PF00015.21 EFE45026.1 - 0.32 10.8 2.5 1.5 8.6 1.2 2.1 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Syntaxin_2 PF14523.6 EFE45026.1 - 0.35 11.3 7.1 3.6 8.0 7.1 2.2 1 1 0 1 1 1 0 Syntaxin-like protein YkyA PF10368.9 EFE45026.1 - 0.38 10.4 5.3 8.8 6.0 5.3 2.4 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein FliD_N PF02465.18 EFE45026.1 - 0.38 11.5 2.7 7.8 7.3 2.7 2.7 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF4164 PF13747.6 EFE45026.1 - 0.42 10.9 2.0 3.4 8.0 2.0 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) Sas10_Utp3 PF04000.15 EFE45026.1 - 0.42 11.3 1.7 14 6.4 0.1 2.8 2 1 1 3 3 3 0 Sas10/Utp3/C1D family ADIP PF11559.8 EFE45026.1 - 0.44 10.6 4.0 2.1 8.4 3.2 2.1 2 1 0 2 2 1 0 Afadin- and alpha -actinin-Binding CorA PF01544.18 EFE45026.1 - 0.49 9.7 3.0 0.66 9.2 1.6 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Sec34 PF04136.15 EFE45026.1 - 0.57 10.0 3.9 2.8 7.8 1.8 2.6 1 1 1 2 2 2 0 Sec34-like family ISG65-75 PF11727.8 EFE45026.1 - 0.68 9.1 2.7 0.9 8.7 2.2 1.5 1 1 0 1 1 1 0 Invariant surface glycoprotein Muted PF14942.6 EFE45026.1 - 1.1 9.6 4.7 1.2 9.4 2.1 2.0 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Snapin_Pallidin PF14712.6 EFE45026.1 - 1.4 9.4 7.9 10 6.6 2.8 3.3 1 1 1 2 2 2 0 Snapin/Pallidin ApoLp-III PF07464.11 EFE45026.1 - 1.4 9.0 6.2 8.4 6.5 6.4 2.1 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF2207 PF09972.9 EFE45028.1 - 0.0054 15.6 1.2 0.0061 15.4 1.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) HORMA PF02301.18 EFE45029.1 - 1.6e-18 67.1 0.0 1.8e-18 66.9 0.0 1.0 1 0 0 1 1 1 1 HORMA domain GTP_EFTU PF00009.27 EFE45030.1 - 5.1e-51 173.0 0.0 8.1e-51 172.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EFE45030.1 - 7.7e-44 148.2 3.3 1.2e-43 147.6 3.3 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EFE45030.1 - 4.9e-21 74.6 0.0 9.3e-21 73.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus Ras PF00071.22 EFE45030.1 - 7.7e-06 25.6 0.0 5.9e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 Ras family GTP_EFTU_D2 PF03144.25 EFE45030.1 - 3.3e-05 24.2 0.7 6.7e-05 23.2 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFE45030.1 - 3.8e-05 23.7 0.0 0.00012 22.2 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EFE45030.1 - 0.00055 20.0 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 EFE45030.1 - 0.0043 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 EFE45030.1 - 0.0062 16.0 0.0 0.015 14.8 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 EFE45030.1 - 0.064 13.3 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Snurportin1 PF11538.8 EFE45030.1 - 0.1 12.8 1.3 0.24 11.6 1.3 1.6 1 0 0 1 1 1 0 Snurportin1 p450 PF00067.22 EFE45031.1 - 8.1e-31 107.3 0.0 1.4e-30 106.5 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Methyltransf_25 PF13649.6 EFE45032.1 - 5.9e-12 46.1 0.0 1e-11 45.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE45032.1 - 5.7e-10 39.7 0.0 9.5e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE45032.1 - 9e-09 36.0 0.0 1.6e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFE45032.1 - 5.9e-07 29.4 0.0 2.3e-06 27.5 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE45032.1 - 0.0046 16.8 0.0 0.0067 16.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 EFE45032.1 - 0.046 13.2 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase MTS PF05175.14 EFE45032.1 - 0.23 11.0 0.0 0.38 10.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain FAD_binding_4 PF01565.23 EFE45035.1 - 2e-25 89.1 3.6 3.1e-25 88.5 3.6 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFE45035.1 - 5.8e-10 39.1 0.0 1.4e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF1529 PF07485.11 EFE45035.1 - 0.13 12.2 0.0 16 5.4 0.0 3.0 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1259) Peptidase_S64 PF08192.11 EFE45036.1 - 2e-05 23.3 0.4 0.0034 16.0 0.2 2.1 2 0 0 2 2 2 2 Peptidase family S64 Trypsin_2 PF13365.6 EFE45036.1 - 3.4e-05 24.8 0.1 0.00012 23.0 0.1 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S29 PF02907.15 EFE45036.1 - 0.0037 17.0 0.0 0.0076 16.0 0.0 1.5 1 0 0 1 1 1 1 Hepatitis C virus NS3 protease ECH_1 PF00378.20 EFE45037.1 - 6.8e-41 140.2 0.1 1.1e-40 139.6 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFE45037.1 - 2.7e-29 102.7 0.0 7.9e-29 101.2 0.0 1.4 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase 2OG-FeII_Oxy_2 PF13532.6 EFE45038.1 - 6.7e-27 94.9 0.1 1.2e-26 94.1 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.20 EFE45038.1 - 9.1e-22 78.1 0.0 4.1e-15 56.4 0.0 2.3 2 0 0 2 2 2 2 Isochorismatase family GST_N_3 PF13417.6 EFE45038.1 - 0.0061 16.9 0.0 0.028 14.8 0.0 2.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFE45038.1 - 0.01 16.0 0.0 0.03 14.5 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFE45038.1 - 0.022 15.1 0.0 0.087 13.2 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Glutaredoxin2_C PF04399.13 EFE45038.1 - 0.022 14.6 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GST_C PF00043.25 EFE45038.1 - 0.078 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFE45038.1 - 0.16 12.0 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain IlvN PF07991.12 EFE45039.1 - 1.4e-44 151.6 0.0 2.2e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EFE45039.1 - 3e-39 134.6 0.1 5.3e-39 133.8 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 EFE45039.1 - 0.035 14.3 0.0 0.069 13.3 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EFE45039.1 - 0.14 12.7 0.2 0.41 11.2 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Amidoligase_2 PF12224.8 EFE45040.1 - 2.2e-13 50.5 0.0 8e-12 45.4 0.0 2.3 1 1 0 1 1 1 1 Putative amidoligase enzyme GGACT PF06094.12 EFE45040.1 - 2.7e-05 24.7 0.0 5.1e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like PALP PF00291.25 EFE45041.1 - 7.9e-50 169.9 0.5 1.3e-48 165.9 0.5 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Rad51 PF08423.11 EFE45042.1 - 0.0039 16.5 0.0 0.014 14.7 0.0 1.8 2 0 0 2 2 2 1 Rad51 Hexose_dehydrat PF03559.14 EFE45042.1 - 0.072 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase TAF8_C PF10406.9 EFE45043.1 - 7.6e-20 71.2 1.7 1.2e-19 70.6 0.3 2.2 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EFE45043.1 - 0.023 14.7 0.1 0.056 13.5 0.0 1.6 2 0 0 2 2 2 0 Bromodomain associated UQ_con PF00179.26 EFE45044.1 - 8.9e-36 122.6 0.0 1.1e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFE45044.1 - 0.092 12.4 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Chitin_synth_1 PF01644.17 EFE45045.1 - 5.2e-69 231.4 0.0 7.5e-69 230.9 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EFE45045.1 - 3e-28 97.6 0.0 5.5e-28 96.7 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EFE45045.1 - 1.4e-22 80.0 0.2 4.5e-18 65.2 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EFE45045.1 - 9.6e-09 35.4 0.1 9.6e-09 35.4 0.1 3.5 5 0 0 5 5 5 1 Glycosyl transferase family group 2 Psu PF07455.11 EFE45045.1 - 0.0038 16.9 0.0 3.3 7.3 0.0 2.3 2 0 0 2 2 2 2 Phage polarity suppression protein (Psu) Tetraspanin PF00335.20 EFE45045.1 - 9.2 5.9 14.3 11 5.7 7.8 2.7 2 0 0 2 2 2 0 Tetraspanin family AMP-binding PF00501.28 EFE45046.1 - 8.7e-48 162.9 0.0 1.2e-47 162.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFE45046.1 - 0.12 13.3 0.1 0.26 12.3 0.1 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Opy2 PF09463.10 EFE45047.1 - 9.3e-09 35.5 19.9 1.6e-08 34.8 19.9 1.4 1 0 0 1 1 1 1 Opy2 protein SKG6 PF08693.10 EFE45047.1 - 0.00021 20.6 0.1 0.00093 18.6 0.1 2.2 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Beta-APP PF03494.13 EFE45047.1 - 0.08 12.8 0.7 0.17 11.8 0.7 1.5 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) MAPEG PF01124.18 EFE45047.1 - 0.11 12.4 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 MAPEG family Tmemb_cc2 PF10267.9 EFE45047.1 - 7.1 5.7 10.1 10 5.2 10.1 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Methyltransf_11 PF08241.12 EFE45048.1 - 0.0027 18.3 0.0 0.0063 17.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE45048.1 - 0.014 16.1 0.1 0.14 12.9 0.0 2.5 2 1 1 3 3 3 0 Methyltransferase domain Methyltransf_31 PF13847.6 EFE45048.1 - 0.027 14.3 0.0 0.97 9.2 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase domain CheR PF01739.18 EFE45048.1 - 0.035 13.6 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain TehB PF03848.14 EFE45048.1 - 0.037 13.4 0.0 0.056 12.9 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB HET PF06985.11 EFE45049.1 - 8.1e-13 49.0 8.4 6.9e-11 42.7 2.9 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Pox_Ag35 PF03286.14 EFE45051.1 - 0.0015 18.3 13.1 0.0017 18.2 13.1 1.2 1 0 0 1 1 1 1 Pox virus Ag35 surface protein RR_TM4-6 PF06459.12 EFE45051.1 - 0.071 12.9 15.5 0.078 12.8 15.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.8 EFE45051.1 - 0.1 11.5 15.4 0.11 11.4 15.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RNA_pol_3_Rpc31 PF11705.8 EFE45051.1 - 0.11 12.7 18.5 0.13 12.5 18.5 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.14 EFE45051.1 - 0.11 10.7 9.6 0.12 10.6 9.6 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4820 PF16091.5 EFE45051.1 - 0.12 11.7 6.1 0.13 11.6 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) SpoIIP PF07454.11 EFE45051.1 - 0.14 11.5 7.6 0.14 11.6 7.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF1682 PF07946.14 EFE45051.1 - 0.26 10.4 20.9 0.33 10.1 20.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) FAM176 PF14851.6 EFE45051.1 - 0.27 10.9 11.2 0.46 10.1 11.2 1.5 1 0 0 1 1 1 0 FAM176 family PPP4R2 PF09184.11 EFE45051.1 - 0.29 10.7 14.1 0.31 10.6 14.1 1.1 1 0 0 1 1 1 0 PPP4R2 Pap_E4 PF02711.14 EFE45051.1 - 0.42 11.6 5.7 0.59 11.1 5.7 1.2 1 0 0 1 1 1 0 E4 protein BORG_CEP PF14957.6 EFE45051.1 - 0.44 11.7 4.9 0.53 11.5 4.9 1.1 1 0 0 1 1 1 0 Cdc42 effector NPR3 PF03666.13 EFE45051.1 - 0.48 9.2 9.7 0.46 9.2 9.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FYDLN_acid PF09538.10 EFE45051.1 - 0.63 10.7 14.8 0.09 13.5 10.9 1.6 2 0 0 2 2 1 0 Protein of unknown function (FYDLN_acid) Zip PF02535.22 EFE45051.1 - 0.64 9.2 4.9 0.68 9.1 4.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GAGA_bind PF06217.12 EFE45051.1 - 0.67 10.2 6.6 0.68 10.2 6.6 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family XRN_N PF03159.18 EFE45051.1 - 0.72 9.2 8.4 0.91 8.9 8.4 1.1 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus AAA_11 PF13086.6 EFE45051.1 - 0.74 9.5 5.8 0.77 9.5 5.8 1.1 1 0 0 1 1 1 0 AAA domain Nop53 PF07767.11 EFE45051.1 - 0.76 9.1 23.4 1.2 8.5 23.4 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DDHD PF02862.17 EFE45051.1 - 0.88 9.7 3.4 0.91 9.6 3.4 1.1 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 EFE45051.1 - 0.9 8.2 9.2 0.93 8.2 9.2 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 EFE45051.1 - 1.3 7.9 6.1 1.3 7.9 6.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FGF-BP1 PF06473.12 EFE45051.1 - 1.4 8.7 10.7 1.6 8.6 10.7 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Paf1 PF03985.13 EFE45051.1 - 1.5 7.8 24.8 1.9 7.4 24.8 1.1 1 0 0 1 1 1 0 Paf1 FancD2 PF14631.6 EFE45051.1 - 1.5 6.1 7.9 1.5 6.1 7.9 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RNA_polI_A34 PF08208.11 EFE45051.1 - 1.6 8.8 23.4 2.1 8.4 23.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Rtf2 PF04641.12 EFE45051.1 - 1.9 7.8 15.3 3 7.1 15.3 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Neur_chan_memb PF02932.16 EFE45051.1 - 1.9 8.5 3.9 2 8.4 3.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF5427 PF10310.9 EFE45051.1 - 2 7.3 15.5 2.4 7.0 15.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Cas_Csy4 PF09618.10 EFE45051.1 - 3 8.0 8.1 4.3 7.4 8.1 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) Sec62 PF03839.16 EFE45051.1 - 3.6 7.0 9.8 5.1 6.5 9.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DNA_pol_phi PF04931.13 EFE45051.1 - 4 5.4 18.6 4.8 5.2 18.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Afi1 PF07792.12 EFE45051.1 - 4.4 7.8 10.1 6 7.3 10.1 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RPN2_C PF18004.1 EFE45051.1 - 5.5 6.9 25.1 9.5 6.1 25.1 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain VIR_N PF15912.5 EFE45051.1 - 5.6 6.5 10.7 6.2 6.3 10.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Eapp_C PF10238.9 EFE45051.1 - 5.7 7.0 11.1 9.3 6.3 11.1 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein Serinc PF03348.15 EFE45051.1 - 6.4 5.6 5.1 6.5 5.6 5.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Hid1 PF12722.7 EFE45051.1 - 7.3 4.6 5.0 7.3 4.6 5.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2828 PF11443.8 EFE45051.1 - 8.6 4.3 9.2 9.5 4.2 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) NOA36 PF06524.12 EFE45051.1 - 8.8 5.6 12.9 12 5.1 12.9 1.2 1 0 0 1 1 1 0 NOA36 protein Spore_coat_CotO PF14153.6 EFE45051.1 - 9.2 6.1 18.0 12 5.8 18.0 1.1 1 0 0 1 1 1 0 Spore coat protein CotO FAA_hydro_N_2 PF18288.1 EFE45052.1 - 0.93 10.0 4.2 0.94 9.9 1.3 2.3 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 Sec1 PF00995.23 EFE45054.1 - 1.9e-127 426.9 0.0 2.3e-127 426.7 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Ribosomal_L28e PF01778.17 EFE45055.1 - 6.6e-32 110.7 0.4 9.3e-32 110.2 0.1 1.3 1 1 0 1 1 1 1 Ribosomal L28e protein family RRM_1 PF00076.22 EFE45056.1 - 1e-34 118.2 0.0 2.1e-16 59.5 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFE45056.1 - 0.00023 21.2 0.0 0.0056 16.8 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 EFE45056.1 - 0.00097 18.7 0.1 0.034 13.7 0.0 2.3 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EFE45056.1 - 0.011 15.8 0.2 0.84 9.8 0.1 2.2 2 0 0 2 2 2 0 Limkain b1 Cas_Cas2CT1978 PF09707.10 EFE45056.1 - 0.014 15.4 0.0 2 8.5 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) CMV_1a_C PF12503.8 EFE45056.1 - 0.076 13.0 0.1 17 5.5 0.0 2.3 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein C terminal OB_RNB PF08206.11 EFE45056.1 - 0.12 12.1 0.1 7.3 6.4 0.0 2.4 2 0 0 2 2 2 0 Ribonuclease B OB domain PHM7_cyt PF14703.6 EFE45056.1 - 0.13 12.5 0.0 1.2 9.3 0.0 2.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_occluded PF16842.5 EFE45056.1 - 0.18 11.7 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Mito_carr PF00153.27 EFE45057.1 - 1.3e-67 223.7 4.5 9.6e-23 79.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-C2H2 PF00096.26 EFE45058.1 - 5.8e-14 51.7 17.4 6.4e-05 23.2 0.9 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFE45058.1 - 8e-13 48.2 19.1 1.9e-06 28.0 1.9 4.9 4 1 1 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFE45058.1 - 2.4e-08 34.1 13.6 0.023 15.5 0.6 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 EFE45058.1 - 4.7e-05 23.6 4.8 0.14 12.5 0.2 3.8 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 EFE45058.1 - 0.0073 16.5 2.2 0.027 14.6 0.2 2.3 1 1 0 2 2 2 1 Aberrant zinc-finger zf-LYAR PF08790.11 EFE45058.1 - 0.069 13.1 8.0 4.3 7.3 0.4 3.6 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.6 EFE45058.1 - 0.11 12.5 0.5 0.11 12.5 0.5 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger FOXP-CC PF16159.5 EFE45058.1 - 0.36 11.5 4.1 18 6.1 0.2 2.8 3 0 0 3 3 3 0 FOXP coiled-coil domain Ldh_1_C PF02866.18 EFE45060.1 - 3.5e-43 147.4 0.0 5.1e-43 146.9 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EFE45060.1 - 7.3e-28 97.4 0.8 6.3e-19 68.5 0.1 2.6 2 1 0 2 2 2 2 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.16 EFE45060.1 - 0.12 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase TRAPP PF04051.16 EFE45061.1 - 0.0019 17.9 0.0 0.0023 17.6 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Glyco_transf_90 PF05686.12 EFE45062.1 - 4.3e-18 65.4 6.9 1.6e-13 50.4 4.4 3.7 2 1 0 2 2 2 2 Glycosyl transferase family 90 PINIT PF14324.6 EFE45063.1 - 6.8e-28 97.8 0.0 9e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 PINIT domain XPC-binding PF09280.11 EFE45064.1 - 2.5e-24 84.8 17.2 2.5e-24 84.8 17.2 1.8 2 0 0 2 2 2 1 XPC-binding domain ubiquitin PF00240.23 EFE45064.1 - 1.9e-22 78.8 0.1 3.3e-22 78.0 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EFE45064.1 - 5.1e-22 77.4 1.9 2.1e-12 46.7 0.1 2.6 2 0 0 2 2 2 2 UBA/TS-N domain Rad60-SLD PF11976.8 EFE45064.1 - 3.6e-08 33.1 0.3 6.5e-08 32.3 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EFE45064.1 - 0.0076 16.0 0.0 2.3 8.1 0.0 2.5 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain Rad60-SLD_2 PF13881.6 EFE45064.1 - 0.031 14.4 0.0 0.06 13.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFE45064.1 - 0.036 14.4 0.1 0.067 13.5 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain Herpes_pp85 PF04637.12 EFE45064.1 - 2 6.7 5.4 2.9 6.2 5.4 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Pheromone PF08015.11 EFE45064.1 - 7.7 7.6 10.0 6.7 7.8 4.3 2.8 2 0 0 2 2 2 0 Fungal mating-type pheromone DUF3431 PF11913.8 EFE45065.1 - 5.5e-71 238.8 2.0 7.6e-70 235.0 0.1 2.3 2 1 0 2 2 2 2 Protein of unknown function (DUF3431) Aminotran_1_2 PF00155.21 EFE45067.1 - 2.2e-31 109.3 0.0 1.3e-30 106.8 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFE45067.1 - 4.5e-08 32.5 0.0 6.8e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EFE45067.1 - 4.3e-05 22.2 0.0 5.6e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EFE45067.1 - 0.00091 18.6 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase PHO4 PF01384.20 EFE45068.1 - 5.1e-125 417.0 15.9 5.8e-125 416.8 15.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family Pkinase_Tyr PF07714.17 EFE45069.1 - 4.4e-13 49.1 0.0 6.1e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFE45069.1 - 5.2e-11 42.4 0.0 1.2e-10 41.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFE45069.1 - 0.02 14.8 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFE45069.1 - 0.034 13.5 0.0 0.054 12.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFE45069.1 - 0.045 13.3 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase TauD PF02668.16 EFE45070.1 - 6e-48 164.0 0.0 7.3e-48 163.7 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF1330 PF07045.11 EFE45070.1 - 0.14 12.5 0.0 1.9 8.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1330) COesterase PF00135.28 EFE45071.1 - 0.014 14.3 0.0 0.02 13.8 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family SRR1 PF07985.12 EFE45072.1 - 1.5e-15 57.0 0.0 3.8e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 SRR1 FliD_C PF07195.12 EFE45072.1 - 0.2 11.1 0.0 19 4.6 0.0 2.3 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus eIF-6 PF01912.18 EFE45073.1 - 1.1e-76 256.7 0.8 1.4e-76 256.3 0.8 1.1 1 0 0 1 1 1 1 eIF-6 family dUTPase PF00692.19 EFE45074.1 - 5.7e-08 32.5 0.0 9.1e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 dUTPase DUF3246 PF11596.8 EFE45074.1 - 0.0049 16.3 2.2 0.0067 15.9 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3246) RXT2_N PF08595.11 EFE45074.1 - 0.0076 16.3 0.2 0.0096 16.0 0.2 1.1 1 0 0 1 1 1 1 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 EFE45074.1 - 0.02 14.6 7.1 0.025 14.3 7.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 EFE45074.1 - 0.045 14.1 7.4 0.068 13.6 7.4 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 EFE45074.1 - 0.076 13.4 6.7 0.1 13.0 6.7 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 EFE45074.1 - 0.1 10.7 1.7 0.12 10.5 1.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 EFE45074.1 - 0.15 11.7 0.3 0.19 11.4 0.3 1.2 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 EFE45074.1 - 0.45 9.8 6.6 0.59 9.4 6.6 1.1 1 0 0 1 1 1 0 NOA36 protein tRNA-synt_His PF13393.6 EFE45075.1 - 8.5e-37 127.1 0.0 1.4e-30 106.7 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EFE45075.1 - 1.9e-13 50.4 0.0 3.4e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EFE45075.1 - 3.5e-05 23.8 0.0 7.5e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 EFE45075.1 - 0.0036 16.9 0.0 0.0065 16.0 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 EFE45075.1 - 0.16 11.0 0.0 0.4 9.7 0.0 1.7 1 1 0 2 2 2 0 tRNA synthetases class II (D, K and N) FAD_binding_3 PF01494.19 EFE45076.1 - 7e-22 78.1 0.0 1.4e-19 70.5 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EFE45076.1 - 0.00066 18.8 0.0 0.0041 16.2 0.0 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EFE45076.1 - 0.0033 16.7 0.0 0.0051 16.1 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFE45076.1 - 0.0072 16.3 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding SE PF08491.10 EFE45076.1 - 0.017 14.2 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase DAO PF01266.24 EFE45076.1 - 0.02 14.5 0.0 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFE45076.1 - 0.031 14.5 0.0 0.09 13.0 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFE45076.1 - 0.098 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) PX PF00787.24 EFE45077.1 - 8.7e-19 67.6 0.4 2.2e-18 66.3 0.4 1.6 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EFE45077.1 - 8e-12 45.2 7.3 1.6e-05 24.6 0.1 2.1 1 1 1 2 2 2 2 Vps5 C terminal like DUF1664 PF07889.12 EFE45077.1 - 0.054 13.5 0.9 2.5 8.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 EFE45077.1 - 0.15 12.8 2.9 2 9.2 0.0 2.8 3 0 0 3 3 3 0 Occludin homology domain Metallophos PF00149.28 EFE45078.1 - 3.5e-11 44.0 0.2 7.1e-11 43.0 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFE45078.1 - 0.00041 20.6 0.0 0.0047 17.1 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ABC_membrane PF00664.23 EFE45080.1 - 2.6e-89 299.5 29.3 6.6e-48 163.7 11.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE45080.1 - 3.8e-60 202.4 0.0 4.9e-29 101.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFE45080.1 - 7.6e-16 58.2 4.6 2.2e-05 24.0 0.0 4.4 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFE45080.1 - 9.3e-09 34.9 1.2 0.0013 18.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFE45080.1 - 8.5e-08 32.6 1.1 0.0053 17.0 0.1 3.8 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFE45080.1 - 7.1e-07 29.8 0.3 0.02 15.3 0.0 3.3 3 1 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFE45080.1 - 7.4e-06 26.0 0.1 0.25 11.2 0.0 3.2 3 0 0 3 3 3 2 RsgA GTPase AAA_25 PF13481.6 EFE45080.1 - 9.3e-06 25.4 0.1 0.058 13.0 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 EFE45080.1 - 1.6e-05 25.6 0.6 0.01 16.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFE45080.1 - 9.8e-05 22.9 0.0 0.67 10.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EFE45080.1 - 0.00016 21.6 9.3 0.47 10.2 0.2 4.4 5 0 0 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 EFE45080.1 - 0.00029 19.8 1.5 0.12 11.2 0.8 3.3 3 0 0 3 3 3 1 Predicted ATPase of the ABC class AAA_15 PF13175.6 EFE45080.1 - 0.00078 19.3 1.9 0.51 10.0 0.2 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EFE45080.1 - 0.0016 18.6 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFE45080.1 - 0.0029 17.7 0.7 0.79 9.8 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase ATPase PF06745.13 EFE45080.1 - 0.0072 15.7 0.2 3.5 6.9 0.0 2.6 2 0 0 2 2 2 1 KaiC AAA_30 PF13604.6 EFE45080.1 - 0.0073 16.0 0.5 4 7.1 0.1 3.4 3 1 0 3 3 3 1 AAA domain AAA_5 PF07728.14 EFE45080.1 - 0.0086 16.1 0.0 1 9.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF3987 PF13148.6 EFE45080.1 - 0.0087 15.1 0.1 3.5 6.6 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3987) IstB_IS21 PF01695.17 EFE45080.1 - 0.0098 15.6 0.7 5.8 6.6 0.0 3.8 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA PF00004.29 EFE45080.1 - 0.013 15.9 0.0 0.95 9.9 0.0 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 EFE45080.1 - 0.013 15.4 0.3 5.3 6.9 0.0 2.8 3 0 0 3 3 2 0 Adenylylsulphate kinase AAA_24 PF13479.6 EFE45080.1 - 0.015 15.1 0.3 1.7 8.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 EFE45080.1 - 0.015 15.4 2.4 0.83 9.7 0.1 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain SbcCD_C PF13558.6 EFE45080.1 - 0.015 15.5 0.1 2.5 8.4 0.0 3.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.22 EFE45080.1 - 0.019 15.3 0.0 13 6.2 0.0 2.8 3 0 0 3 3 2 0 RNA helicase G-alpha PF00503.20 EFE45080.1 - 0.03 13.5 0.1 0.38 9.9 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 EFE45080.1 - 0.064 12.8 0.0 10 5.6 0.0 2.7 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 EFE45080.1 - 0.095 12.6 0.3 37 4.2 0.1 3.4 3 0 0 3 3 3 0 NACHT domain Guanylate_kin PF00625.21 EFE45080.1 - 0.15 11.8 0.0 8.9 6.0 0.0 2.3 2 0 0 2 2 2 0 Guanylate kinase AcrZ PF10766.9 EFE45080.1 - 0.16 11.6 4.5 0.26 10.9 0.1 2.6 2 0 0 2 2 2 0 Multidrug efflux pump-associated protein AcrZ Mg_chelatase PF01078.21 EFE45080.1 - 0.2 11.0 0.1 2.5 7.4 0.1 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Cytidylate_kin PF02224.18 EFE45080.1 - 0.22 11.2 0.9 1.7 8.3 0.2 2.4 2 0 0 2 2 2 0 Cytidylate kinase FtsK_SpoIIIE PF01580.18 EFE45080.1 - 0.25 10.6 1.3 19 4.5 0.0 2.5 3 0 0 3 3 2 0 FtsK/SpoIIIE family MFS_1 PF07690.16 EFE45081.1 - 8.6e-31 107.1 44.5 8.6e-31 107.1 44.5 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily p450 PF00067.22 EFE45082.1 - 1.1e-43 149.7 0.2 1.3e-43 149.5 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ric8 PF10165.9 EFE45083.1 - 2.2e-119 399.5 0.1 2.8e-119 399.2 0.1 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Polysacc_synt_4 PF04669.13 EFE45084.1 - 3.1e-17 62.8 0.8 9.5e-16 57.9 0.8 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Sugar_tr PF00083.24 EFE45085.1 - 2.1e-133 445.5 17.4 7.1e-96 321.8 11.4 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFE45085.1 - 3.5e-22 78.8 27.5 3.9e-18 65.5 13.0 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFE45085.1 - 0.00011 20.9 20.6 0.00041 19.0 7.7 3.0 2 1 1 3 3 3 2 MFS/sugar transport protein BT1 PF03092.16 EFE45085.1 - 0.02 13.1 0.7 4.1 5.5 0.7 2.3 2 0 0 2 2 2 0 BT1 family Glyco_hydro_25 PF01183.20 EFE45086.1 - 3e-40 138.3 0.0 3.5e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 Rif1_N PF12231.8 EFE45087.1 - 3e-125 418.1 0.0 5e-125 417.4 0.0 1.4 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal DUF3995 PF13160.6 EFE45088.1 - 0.023 15.1 0.1 0.033 14.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3995) Aldose_epim PF01263.20 EFE45089.1 - 5.3e-36 124.4 0.0 6.4e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase BclA_C PF18573.1 EFE45089.1 - 0.062 13.2 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 BclA C-terminal domain MFS_1 PF07690.16 EFE45090.1 - 1e-24 87.2 26.1 1e-24 87.2 26.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DAHP_synth_2 PF01474.16 EFE45092.1 - 5.3e-144 480.0 0.0 5.9e-144 479.8 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family AT_hook PF02178.19 EFE45093.1 - 8 6.7 10.8 1.5 8.9 2.8 3.8 2 0 0 2 2 2 0 AT hook motif PLA2_B PF01735.18 EFE45094.1 - 1.2e-188 627.6 0.6 1.4e-188 627.3 0.6 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Nucleo_P87 PF07267.11 EFE45095.1 - 0.12 11.2 0.1 0.12 11.2 0.1 1.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 adh_short_C2 PF13561.6 EFE45096.1 - 9.1e-60 202.1 0.3 1.1e-59 201.9 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFE45096.1 - 1.8e-50 171.1 1.1 2.3e-50 170.8 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFE45096.1 - 2.1e-16 60.4 0.3 2.8e-16 60.0 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFE45096.1 - 0.00083 18.9 0.4 0.0014 18.2 0.4 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFE45096.1 - 0.0026 17.2 0.2 0.0043 16.5 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase GGACT PF06094.12 EFE45097.1 - 1.6e-15 57.8 0.3 1.9e-15 57.6 0.3 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Piwi PF02171.17 EFE45098.1 - 2.2e-73 247.2 0.0 3.2e-73 246.6 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EFE45098.1 - 2.7e-16 60.4 0.0 5e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EFE45098.1 - 1.7e-12 46.8 0.1 5.5e-12 45.2 0.1 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EFE45098.1 - 1.2e-07 31.9 0.0 3.1e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 EFE45098.1 - 3e-07 30.3 0.0 6.2e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EFE45098.1 - 0.0026 18.0 0.0 0.0068 16.6 0.0 1.8 1 0 0 1 1 1 1 Mid domain of argonaute RIBIOP_C PF04950.12 EFE45098.1 - 0.15 11.5 0.1 0.24 10.8 0.1 1.2 1 0 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal PRCC PF10253.9 EFE45099.1 - 0.083 13.7 6.3 0.088 13.6 6.3 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF1180 PF06679.12 EFE45099.1 - 2.9 8.3 8.8 3.8 7.9 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Ribophorin_II PF05817.14 EFE45100.1 - 3.4e-30 105.2 0.1 4e-30 105.0 0.1 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II PufQ PF05398.11 EFE45100.1 - 0.017 15.2 1.0 0.47 10.6 0.1 2.3 2 0 0 2 2 2 0 PufQ cytochrome subunit EVE PF01878.18 EFE45102.1 - 1.9e-44 151.2 1.8 2.5e-44 150.8 0.0 1.9 2 0 0 2 2 2 1 EVE domain DUF4551 PF15087.6 EFE45102.1 - 7 5.3 7.8 8.2 5.1 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Methyltransf_PK PF05891.12 EFE45103.1 - 8.4e-66 221.6 0.0 1.4e-65 220.9 0.0 1.3 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_2 PF00891.18 EFE45103.1 - 3.3e-08 33.1 0.1 7.9e-08 31.8 0.1 1.6 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EFE45103.1 - 8.5e-06 26.4 0.0 1.7e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFE45103.1 - 0.00013 22.5 0.0 0.00024 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFE45103.1 - 0.0053 17.5 0.0 0.012 16.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFE45103.1 - 0.0082 16.0 0.0 0.02 14.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Bin3 PF06859.12 EFE45103.1 - 0.03 14.9 0.0 0.051 14.2 0.0 1.3 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) Sec23_helical PF04815.15 EFE45103.1 - 0.13 12.1 0.0 1.7 8.5 0.0 2.1 1 1 0 1 1 1 0 Sec23/Sec24 helical domain Aldedh PF00171.22 EFE45104.1 - 9.3e-181 601.3 3.5 1.1e-180 601.1 3.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EFE45104.1 - 0.0021 17.5 0.0 0.0089 15.5 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) PAF PF15715.5 EFE45107.1 - 0.035 14.7 0.7 0.063 13.9 0.7 1.3 1 0 0 1 1 1 0 PCNA-associated factor histone like domain Glyco_hydro_30C PF17189.4 EFE45107.1 - 0.074 13.3 0.0 0.17 12.2 0.0 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain Bac_surface_Ag PF01103.23 EFE45109.1 - 2.3e-43 148.9 0.0 2.9e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 Surface antigen Yip1 PF04893.17 EFE45110.1 - 6.2e-07 29.3 12.0 0.00011 22.0 8.1 2.4 2 0 0 2 2 2 2 Yip1 domain Macoilin PF09726.9 EFE45111.1 - 6.3 5.2 16.5 6.8 5.1 16.5 1.1 1 0 0 1 1 1 0 Macoilin family RR_TM4-6 PF06459.12 EFE45111.1 - 8.1 6.2 15.4 12 5.6 15.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 UFD1 PF03152.14 EFE45113.1 - 8e-30 103.6 0.0 1.2e-27 96.5 0.0 2.8 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 EFE45113.1 - 1.1e-06 28.8 0.6 4.1e-06 26.9 0.6 1.9 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A PEX-1N PF09262.11 EFE45113.1 - 0.069 13.6 0.1 0.21 12.0 0.0 1.9 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal zf-C2H2 PF00096.26 EFE45113.1 - 4.5 7.9 25.7 1.9 9.1 2.2 4.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type DPPIV_N PF00930.21 EFE45114.1 - 3.4e-111 371.4 5.9 5.7e-111 370.7 5.9 1.4 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EFE45114.1 - 4.1e-30 104.9 1.8 3e-25 88.9 0.2 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EFE45114.1 - 0.042 14.5 0.0 0.093 13.3 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFE45114.1 - 0.16 11.2 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_S8 PF00082.22 EFE45115.1 - 6.5e-24 84.7 16.0 1.3e-23 83.7 16.0 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFE45115.1 - 5.3e-14 52.6 0.1 9.4e-14 51.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 MAPEG PF01124.18 EFE45116.1 - 3.3e-11 43.2 1.7 4.1e-11 42.9 1.7 1.2 1 0 0 1 1 1 1 MAPEG family MARVEL PF01284.23 EFE45117.1 - 2.1e-07 31.1 4.5 2.5e-07 30.8 4.5 1.1 1 0 0 1 1 1 1 Membrane-associating domain ABC2_membrane_5 PF13346.6 EFE45117.1 - 0.082 12.4 8.0 0.13 11.8 7.9 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF1129 PF06570.11 EFE45117.1 - 1.5 8.3 4.4 2.1 7.8 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) RNB PF00773.19 EFE45118.1 - 1.9e-54 185.2 0.0 2.1e-52 178.5 0.0 2.2 1 1 0 1 1 1 1 RNB domain CTNNBL PF08216.11 EFE45119.1 - 2.8e-20 72.4 1.3 8.8e-20 70.8 0.0 2.5 3 0 0 3 3 3 1 Catenin-beta-like, Arm-motif containing nuclear Drf_GBD PF06371.13 EFE45119.1 - 0.019 14.6 0.6 0.52 9.9 0.0 3.3 4 1 0 4 4 4 0 Diaphanous GTPase-binding Domain PHTB1_C PF14728.6 EFE45119.1 - 0.038 13.1 0.1 0.073 12.1 0.1 1.4 1 0 0 1 1 1 0 PTHB1 C-terminus V-ATPase_H_C PF11698.8 EFE45119.1 - 0.13 12.4 0.6 15 5.8 0.0 2.9 3 0 0 3 3 3 0 V-ATPase subunit H HEAT_2 PF13646.6 EFE45119.1 - 0.14 12.5 0.0 1.1 9.7 0.0 2.7 1 1 1 2 2 2 0 HEAT repeats OAS1_C PF10421.9 EFE45119.1 - 0.15 11.5 0.1 0.44 10.0 0.0 1.7 2 0 0 2 2 2 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus RNA_pol_Rpb2_6 PF00562.28 EFE45120.1 - 3.4e-123 411.6 0.7 4.4e-123 411.2 0.1 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFE45120.1 - 8.5e-60 201.7 0.0 2.3e-59 200.3 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EFE45120.1 - 2.9e-47 160.8 0.0 5e-47 160.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 EFE45120.1 - 1.2e-25 89.5 0.1 3e-25 88.2 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 EFE45120.1 - 1.5e-24 86.0 0.4 3.5e-24 84.9 0.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 EFE45120.1 - 5.7e-23 81.2 1.9 1.2e-22 80.2 0.4 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_7 PF04560.20 EFE45120.1 - 2.5e-18 66.2 0.0 5.6e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 AMPK1_CBM PF16561.5 EFE45121.1 - 3.7e-05 23.8 0.0 6.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase DUF951 PF06107.11 EFE45121.1 - 0.27 11.2 1.3 0.48 10.4 1.3 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) DUF2306 PF10067.9 EFE45122.1 - 6.1e-16 59.0 4.4 6.1e-16 59.0 4.4 1.8 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) DUF420 PF04238.12 EFE45122.1 - 0.0012 19.2 0.2 0.0012 19.2 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF420) Sugar_tr PF00083.24 EFE45123.1 - 1.2e-65 222.2 23.0 1.1e-52 179.4 12.5 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFE45123.1 - 1.3e-23 83.5 35.1 2.2e-11 43.3 12.3 3.1 1 1 1 3 3 3 3 Major Facilitator Superfamily Zn_clus PF00172.18 EFE45124.1 - 0.012 15.7 0.6 0.034 14.3 0.6 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain IL31 PF15209.6 EFE45124.1 - 0.062 13.1 0.3 3.4 7.4 0.1 2.4 2 0 0 2 2 2 0 Interleukin 31 ABC_membrane PF00664.23 EFE45125.1 - 3.9e-106 354.7 38.1 2.5e-56 191.3 11.4 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFE45125.1 - 8.9e-67 223.8 0.0 1e-32 113.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFE45125.1 - 2.1e-14 53.5 0.0 4.8e-05 22.9 0.0 3.4 1 1 2 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFE45125.1 - 1.1e-07 31.9 1.4 0.023 14.4 0.4 3.0 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EFE45125.1 - 1e-06 28.4 0.4 0.0052 16.5 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFE45125.1 - 2.2e-06 27.7 0.0 0.2 11.6 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase ABC_ATPase PF09818.9 EFE45125.1 - 5.8e-06 25.4 0.2 0.056 12.2 0.0 2.6 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 EFE45125.1 - 9.8e-06 26.1 2.1 0.21 11.9 0.2 3.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_25 PF13481.6 EFE45125.1 - 0.00079 19.0 0.0 0.53 9.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain G-alpha PF00503.20 EFE45125.1 - 0.00093 18.5 0.0 1 8.4 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_21 PF13304.6 EFE45125.1 - 0.0017 18.3 5.6 2.1 8.1 0.3 4.2 2 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFE45125.1 - 0.0026 18.1 2.6 2.9 8.2 0.1 3.6 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EFE45125.1 - 0.0066 15.7 0.2 1.4 8.1 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin AAA_28 PF13521.6 EFE45125.1 - 0.0068 16.7 0.6 0.74 10.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EFE45125.1 - 0.0083 16.6 0.1 1.9 9.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 EFE45125.1 - 0.0098 16.1 3.3 5.3 7.4 0.5 3.7 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 EFE45125.1 - 0.012 15.8 0.7 5.4 7.2 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_5 PF07728.14 EFE45125.1 - 0.013 15.5 0.0 4.4 7.3 0.0 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFE45125.1 - 0.013 16.0 0.0 11 6.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFE45125.1 - 0.016 14.7 0.1 5.5 6.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EFE45125.1 - 0.019 14.7 4.3 3.7 7.2 0.0 4.1 6 0 0 6 6 5 0 AAA domain DUF87 PF01935.17 EFE45125.1 - 0.047 13.8 0.8 0.79 9.8 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain RNA_helicase PF00910.22 EFE45125.1 - 0.1 13.0 0.4 8.4 6.8 0.0 3.1 3 0 0 3 3 2 0 RNA helicase Rad17 PF03215.15 EFE45125.1 - 0.14 12.1 0.0 0.83 9.5 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 EFE45125.1 - 0.24 11.5 0.8 14 5.8 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF3433 PF11915.8 EFE45125.1 - 8.1 7.0 8.6 25 5.4 0.0 3.3 3 0 0 3 3 2 0 Protein of unknown function (DUF3433) Transferase PF02458.15 EFE45126.1 - 5.2e-12 45.2 0.0 3e-10 39.3 0.0 2.7 1 1 0 1 1 1 1 Transferase family FSH1 PF03959.13 EFE45127.1 - 2.6e-20 73.0 0.1 2e-12 47.2 0.1 3.2 1 1 2 3 3 3 2 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EFE45127.1 - 0.00023 21.8 0.0 0.00032 21.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EFE45127.1 - 0.021 14.6 0.1 1.1 9.1 0.2 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PE-PPE PF08237.11 EFE45127.1 - 0.032 13.8 0.0 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 PE-PPE domain PatG_D PF18047.1 EFE45127.1 - 0.086 13.3 0.0 8.7 6.8 0.0 2.2 1 1 1 2 2 2 0 PatG Domain Hydrolase_4 PF12146.8 EFE45127.1 - 0.099 11.9 0.0 0.25 10.6 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Viral_DNA_bi PF02236.17 EFE45127.1 - 0.16 12.1 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 Viral DNA-binding protein, all alpha domain TilS PF09179.11 EFE45127.1 - 0.32 11.5 1.7 2.5 8.6 1.7 2.2 1 1 0 1 1 1 0 TilS substrate binding domain p450 PF00067.22 EFE45128.1 - 3.5e-29 101.9 0.0 4.1e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADH_N PF08240.12 EFE45129.1 - 1.5e-17 63.4 1.6 3e-17 62.5 1.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFE45129.1 - 1.8e-13 50.6 0.1 2.9e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EFE45129.1 - 0.00033 20.1 0.1 0.00051 19.4 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EFE45129.1 - 0.0019 17.5 0.1 0.0029 16.9 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 EFE45129.1 - 0.0029 17.4 0.1 0.0052 16.5 0.1 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_10 PF13460.6 EFE45129.1 - 0.044 13.7 0.0 0.066 13.1 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding Mito_carr PF00153.27 EFE45130.1 - 1.4e-39 133.9 8.8 7.4e-16 57.8 0.3 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein NAD_binding_6 PF08030.12 EFE45131.1 - 8e-14 52.0 0.0 1e-13 51.7 0.0 1.1 1 0 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EFE45131.1 - 0.052 14.2 0.0 0.99 10.1 0.0 2.1 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain FAD_binding_8 PF08022.12 EFE45131.1 - 0.064 13.3 0.0 0.18 11.9 0.0 1.7 2 0 0 2 2 2 0 FAD-binding domain Host_attach PF10116.9 EFE45131.1 - 0.1 13.2 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein required for attachment to host cells baeRF_family12 PF18856.1 EFE45131.1 - 0.19 12.3 0.0 0.31 11.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 ABC1 PF03109.16 EFE45132.1 - 7.6e-22 77.7 0.2 2e-21 76.3 0.0 1.9 2 0 0 2 2 2 1 ABC1 family APH PF01636.23 EFE45132.1 - 0.05 13.5 0.8 0.17 11.8 0.3 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family IMS PF00817.20 EFE45133.1 - 1.1e-35 122.9 0.0 1.5e-21 76.9 0.0 2.3 2 0 0 2 2 2 2 impB/mucB/samB family IMS_C PF11799.8 EFE45133.1 - 5.3e-12 46.5 0.0 1.1e-11 45.5 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 EFE45133.1 - 8.9e-12 44.4 1.3 1.8e-11 43.4 1.3 1.5 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger WSC PF01822.19 EFE45135.1 - 1.9e-07 31.2 9.9 1.9e-07 31.2 9.9 2.7 3 1 0 3 3 3 1 WSC domain FixQ PF05545.11 EFE45135.1 - 0.027 14.4 0.1 0.057 13.4 0.1 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DUF2207 PF09972.9 EFE45135.1 - 0.15 10.8 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Utp14 PF04615.13 EFE45135.1 - 0.35 9.4 3.7 0.43 9.1 3.7 1.0 1 0 0 1 1 1 0 Utp14 protein Transp_cyt_pur PF02133.15 EFE45136.1 - 3.7e-25 88.6 32.7 3.7e-25 88.6 32.7 1.5 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin PRP38 PF03371.15 EFE45137.1 - 9e-65 217.8 0.0 1.2e-64 217.4 0.0 1.0 1 0 0 1 1 1 1 PRP38 family CSN4_RPN5_eIF3a PF18420.1 EFE45138.1 - 0.068 13.4 0.4 0.19 11.9 0.1 1.9 2 0 0 2 2 2 0 CSN4/RPN5/eIF3a helix turn helix domain WD40 PF00400.32 EFE45139.1 - 4.5e-17 62.1 2.7 0.15 12.9 0.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFE45139.1 - 0.0032 17.7 0.0 7.9 6.9 0.0 3.9 2 2 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Trypan_PARP PF05887.11 EFE45139.1 - 0.0045 17.0 4.1 0.0045 17.0 4.1 2.3 2 0 0 2 2 2 2 Procyclic acidic repetitive protein (PARP) PALB2_WD40 PF16756.5 EFE45139.1 - 0.097 11.6 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain AAA_12 PF13087.6 EFE45140.1 - 8.7e-38 129.9 0.0 1.4e-37 129.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFE45140.1 - 5.1e-25 88.8 0.0 1.6e-24 87.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFE45140.1 - 4.1e-10 39.7 0.0 2.2e-07 30.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EFE45140.1 - 1.3e-09 38.5 0.0 2e-08 34.7 0.0 2.4 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EFE45140.1 - 3.8e-07 30.1 0.1 0.00033 20.5 0.0 3.3 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EFE45140.1 - 0.00058 19.9 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFE45140.1 - 0.00063 19.6 0.0 0.0017 18.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.16 EFE45140.1 - 0.00092 18.7 0.0 0.0022 17.5 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.9 EFE45140.1 - 0.0057 15.9 0.3 0.32 10.2 0.0 2.6 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.12 EFE45140.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Helicase_RecD PF05127.14 EFE45140.1 - 0.12 12.2 0.0 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 Helicase UvrD-helicase PF00580.21 EFE45140.1 - 0.15 11.6 0.1 0.41 10.1 0.0 1.7 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain ABC_tran PF00005.27 EFE45142.1 - 2.5e-56 190.0 0.2 8.7e-31 107.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFE45142.1 - 3.8e-50 171.1 31.0 1.4e-33 116.7 14.0 3.4 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EFE45142.1 - 3.2e-07 30.0 8.6 0.015 14.7 0.4 4.6 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFE45142.1 - 2.2e-06 27.7 1.7 0.053 13.3 0.0 3.5 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EFE45142.1 - 6.2e-06 26.3 0.2 0.022 14.8 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFE45142.1 - 8.2e-06 25.8 0.1 0.15 11.9 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EFE45142.1 - 3.5e-05 24.4 7.9 0.00063 20.3 0.1 2.9 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EFE45142.1 - 0.00022 20.9 0.3 0.51 10.1 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 EFE45142.1 - 0.00071 19.7 1.0 0.025 14.7 0.0 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 EFE45142.1 - 0.0018 18.5 1.0 6.7 7.0 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EFE45142.1 - 0.0021 17.7 0.1 0.19 11.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFE45142.1 - 0.0023 18.3 0.7 3.9 7.8 0.0 3.2 4 0 0 4 4 2 2 AAA ATPase domain T2SSE PF00437.20 EFE45142.1 - 0.0024 17.0 0.2 0.028 13.5 0.1 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA PF00004.29 EFE45142.1 - 0.013 15.9 0.3 3.2 8.2 0.0 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EFE45142.1 - 0.02 14.2 0.4 1.9 7.7 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 EFE45142.1 - 0.032 14.0 2.1 2.9 7.6 0.0 3.2 4 0 0 4 4 3 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 EFE45142.1 - 0.042 13.2 0.3 0.49 9.7 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_7 PF12775.7 EFE45142.1 - 0.055 13.0 0.2 13 5.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 EFE45142.1 - 0.091 13.3 0.1 14 6.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EFE45142.1 - 0.13 12.3 0.0 12 5.8 0.0 2.8 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit DEAD PF00270.29 EFE45142.1 - 0.13 12.0 0.0 3.2 7.5 0.0 2.8 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_15 PF13175.6 EFE45142.1 - 0.15 11.8 2.5 0.81 9.3 0.0 2.7 3 0 0 3 3 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 EFE45142.1 - 0.22 10.4 2.2 2.3 7.1 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Adeno_IVa2 PF02456.15 EFE45142.1 - 0.24 10.1 0.6 0.81 8.4 0.2 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein cobW PF02492.19 EFE45142.1 - 0.38 10.3 2.5 0.93 9.1 0.4 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 EFE45142.1 - 0.71 9.9 3.5 10 6.2 0.4 2.8 2 0 0 2 2 2 0 Dynamin family NACHT PF05729.12 EFE45142.1 - 0.73 9.7 3.0 5.4 6.9 0.3 2.5 2 0 0 2 2 2 0 NACHT domain Peptidase_M36 PF02128.15 EFE45143.1 - 4.2e-156 519.8 0.2 5.5e-156 519.4 0.2 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EFE45143.1 - 2.1e-16 59.5 3.1 2.1e-16 59.5 3.1 2.2 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 EFE45143.1 - 6e-05 23.0 0.0 0.00017 21.5 0.0 1.7 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain Colicin_M PF14859.6 EFE45143.1 - 0.06 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Colicin M UQ_con PF00179.26 EFE45144.1 - 1.4e-38 131.7 0.0 1.8e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFE45144.1 - 0.015 15.6 0.4 0.028 14.7 0.4 1.6 1 1 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EFE45144.1 - 0.033 13.9 0.0 0.11 12.2 0.0 1.7 1 1 0 1 1 1 0 Prokaryotic E2 family B Bax1-I PF01027.20 EFE45145.1 - 1.1e-55 188.7 27.8 1.3e-55 188.5 27.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 SLATT_4 PF18186.1 EFE45145.1 - 1.9 8.1 3.7 1 9.0 0.8 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 Aa_trans PF01490.18 EFE45146.1 - 9.2e-70 235.4 25.6 2.1e-39 135.4 2.7 3.2 2 1 1 3 3 3 3 Transmembrane amino acid transporter protein DUF2417 PF10329.9 EFE45146.1 - 8.4 5.7 17.2 8.7 5.7 0.2 4.6 3 2 0 3 3 3 0 Region of unknown function (DUF2417) Glyco_hydro_75 PF07335.11 EFE45147.1 - 1.1e-60 204.7 0.2 1.3e-60 204.4 0.2 1.1 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 EMC1_C PF07774.13 EFE45148.1 - 2.1e-74 249.8 0.0 4.6e-74 248.7 0.0 1.5 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EFE45148.1 - 1.6e-18 67.2 10.2 1.1e-16 61.1 2.6 2.7 2 1 1 3 3 3 3 PQQ-like domain PQQ PF01011.21 EFE45148.1 - 3.2e-06 26.8 4.3 8.3 6.5 0.0 5.6 5 0 0 5 5 5 3 PQQ enzyme repeat AT_hook PF02178.19 EFE45149.1 - 2.9e-07 29.6 67.3 0.019 14.8 2.0 6.7 6 0 0 6 6 6 6 AT hook motif DENN PF02141.21 EFE45150.1 - 6.1e-56 189.3 0.1 1.1e-55 188.5 0.1 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EFE45150.1 - 1.6e-15 57.6 0.4 8.1e-15 55.3 0.0 2.5 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 EFE45150.1 - 3e-14 52.7 0.7 7.3e-14 51.5 0.7 1.7 1 0 0 1 1 1 1 dDENN domain C1_2 PF03107.16 EFE45150.1 - 1.2e-06 28.7 4.6 3.2e-06 27.3 4.6 1.7 1 0 0 1 1 1 1 C1 domain C1_1 PF00130.22 EFE45150.1 - 0.0049 16.7 5.8 0.01 15.7 5.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EFE45150.1 - 0.14 12.3 5.9 0.31 11.2 5.9 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger Zn_ribbon_17 PF17120.5 EFE45150.1 - 2.5 7.8 7.6 4.6 6.9 7.6 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 EFE45150.1 - 2.9 7.8 8.7 2.2 8.2 6.6 1.9 1 1 1 2 2 2 0 PHD-finger zf-HIT PF04438.16 EFE45150.1 - 7.6 6.5 5.5 18 5.3 5.5 1.6 1 1 0 1 1 1 0 HIT zinc finger Dabb PF07876.12 EFE45151.1 - 0.16 12.6 1.3 0.16 12.6 1.3 1.0 1 0 0 1 1 1 0 Stress responsive A/B Barrel Domain DUF974 PF06159.13 EFE45153.1 - 1e-56 192.5 0.0 1.1e-56 192.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) CENP-N PF05238.13 EFE45154.1 - 4.3e-120 401.8 5.7 1.2e-119 400.3 5.7 1.6 1 1 0 1 1 1 1 Kinetochore protein CHL4 like bZIP_2 PF07716.15 EFE45155.1 - 1.5e-12 47.3 12.1 1.5e-12 47.3 12.1 2.3 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 EFE45155.1 - 7.9e-05 22.7 10.9 7.9e-05 22.7 10.9 2.2 2 0 0 2 2 2 1 bZIP transcription factor DUF4094 PF13334.6 EFE45155.1 - 0.19 12.2 2.1 0.85 10.1 2.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) BRO1 PF03097.18 EFE45156.1 - 2.2e-102 342.8 1.5 1.6e-98 330.0 0.0 3.6 3 1 0 3 3 3 2 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EFE45156.1 - 6e-88 295.0 12.3 1.5e-87 293.6 12.3 1.7 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Cellulase-like PF12876.7 EFE45156.1 - 0.0089 15.4 0.8 0.062 12.6 0.1 2.0 2 0 0 2 2 2 1 Sugar-binding cellulase-like GAS PF13851.6 EFE45156.1 - 5.9 6.2 12.7 0.46 9.8 4.7 3.0 3 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding Mito_carr PF00153.27 EFE45157.1 - 8.7e-27 92.9 3.8 1.7e-16 59.9 0.4 3.9 3 1 0 3 3 3 2 Mitochondrial carrier protein Thiolase_N PF00108.23 EFE45159.1 - 2.9e-14 53.1 0.1 4.4e-13 49.2 0.1 2.2 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFE45159.1 - 8.1e-12 44.9 3.0 7.6e-11 41.7 0.9 2.8 2 1 1 3 3 3 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EFE45159.1 - 1.3e-07 31.4 0.1 1e-05 25.3 0.1 2.7 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 EFE45159.1 - 0.003 17.2 0.1 0.0063 16.1 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.11 EFE45159.1 - 0.013 14.2 0.4 0.042 12.6 0.1 1.9 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) HSD3 PF15244.6 EFE45160.1 - 1.2 8.6 4.7 0.14 11.6 0.9 1.4 2 0 0 2 2 2 0 Spermatogenesis-associated protein 7, or HSD3 RRM_1 PF00076.22 EFE45161.1 - 5.5e-15 54.9 0.0 1.4e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFE45161.1 - 0.018 15.1 0.1 0.1 12.7 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif Nup35_RRM_2 PF14605.6 EFE45161.1 - 0.1 12.6 0.0 0.43 10.6 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif TRAM_LAG1_CLN8 PF03798.16 EFE45162.1 - 7.4e-40 136.8 24.1 1e-39 136.4 22.6 1.8 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EFE45162.1 - 1.7e-13 50.0 3.8 1.8e-13 49.9 0.1 2.5 2 0 0 2 2 2 1 TRAM1-like protein bMG5 PF17972.1 EFE45163.1 - 0.014 15.8 0.0 0.017 15.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG5 domain Radial_spoke PF04712.12 EFE45163.1 - 0.37 9.7 6.0 0.36 9.7 6.0 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein AA_permease_2 PF13520.6 EFE45164.1 - 6.3e-46 157.1 54.8 8.3e-46 156.7 54.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE45164.1 - 3.2e-21 75.5 51.7 2.9e-20 72.3 51.7 2.2 1 1 0 1 1 1 1 Amino acid permease PPTA PF01239.22 EFE45168.1 - 0.00083 19.0 6.6 0.21 11.4 1.2 3.3 3 0 0 3 3 3 2 Protein prenyltransferase alpha subunit repeat Velvet PF11754.8 EFE45170.1 - 3.4e-50 171.3 0.1 1.1e-31 110.8 0.0 4.8 2 2 1 3 3 3 2 Velvet factor BST2 PF16716.5 EFE45172.1 - 3.1 8.4 6.1 0.27 11.8 0.8 2.0 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 D-ser_dehydrat PF14031.6 EFE45173.1 - 1.4e-24 86.5 0.0 4.4e-24 85.0 0.0 1.9 2 0 0 2 2 2 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EFE45173.1 - 1.9e-13 50.6 0.0 3e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ribonuc_L-PSP PF01042.21 EFE45174.1 - 1.3e-34 118.8 0.1 1.4e-28 99.3 0.0 2.0 2 0 0 2 2 2 2 Endoribonuclease L-PSP NESP55 PF06390.12 EFE45175.1 - 0.045 13.4 8.2 0.046 13.3 8.2 1.0 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Med19 PF10278.9 EFE45175.1 - 0.38 10.7 11.9 0.42 10.5 11.9 1.0 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF3464 PF11947.8 EFE45175.1 - 2.8 7.7 5.3 3 7.6 5.3 1.0 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peptidase_S49_N PF08496.10 EFE45175.1 - 3 7.9 7.6 2.9 7.9 7.6 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DHDPS PF00701.22 EFE45176.1 - 3.6e-34 117.8 0.0 2.1e-33 115.3 0.0 1.8 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family MFS_1 PF07690.16 EFE45177.1 - 4.4e-30 104.8 24.3 6.2e-30 104.3 24.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily PEP_mutase PF13714.6 EFE45178.1 - 3e-65 220.0 0.0 3.7e-65 219.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase MinE PF03776.14 EFE45178.1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE Cyclase PF04199.13 EFE45179.1 - 5.2e-14 52.6 0.0 1.2e-13 51.4 0.0 1.5 1 1 0 1 1 1 1 Putative cyclase APH PF01636.23 EFE45180.1 - 0.0046 16.9 0.0 0.021 14.7 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family AA_permease_2 PF13520.6 EFE45181.1 - 2.4e-56 191.4 34.8 3.1e-56 191.0 34.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFE45181.1 - 3.5e-27 95.1 33.1 4.2e-27 94.9 33.1 1.0 1 0 0 1 1 1 1 Amino acid permease UQ_con PF00179.26 EFE45182.1 - 4.6e-12 45.8 0.0 7.7e-09 35.3 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme JmjC PF02373.22 EFE45183.1 - 3.3e-38 130.6 1.3 5e-38 130.0 0.5 1.8 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H PF13771.6 EFE45183.1 - 1.1e-18 67.3 2.7 2e-18 66.4 2.7 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EFE45183.1 - 2.5e-18 66.3 2.8 4.1e-18 65.5 2.8 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain JmjN PF02375.17 EFE45183.1 - 9.2e-14 51.1 0.3 2.3e-13 49.8 0.3 1.8 1 0 0 1 1 1 1 jmjN domain Carn_acyltransf PF00755.20 EFE45184.1 - 3.6e-198 659.9 0.0 4.5e-198 659.6 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase RhoGAP PF00620.27 EFE45186.1 - 6.7e-46 155.9 0.1 2.2e-45 154.2 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 EFE45186.1 - 8e-14 51.6 18.5 2.9e-09 37.0 2.7 2.4 2 0 0 2 2 2 2 LIM domain CENP-H PF05837.12 EFE45186.1 - 0.072 13.5 0.1 0.072 13.5 0.1 2.9 2 1 0 2 2 2 0 Centromere protein H (CENP-H) TF_Zn_Ribbon PF08271.12 EFE45186.1 - 7.9 6.1 17.5 33 4.1 0.1 4.4 3 1 0 3 3 3 0 TFIIB zinc-binding TFR_dimer PF04253.15 EFE45188.1 - 1.8e-30 105.5 0.0 3e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EFE45188.1 - 2.9e-20 72.8 0.0 6.8e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EFE45188.1 - 3.4e-09 36.6 0.0 8e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EFE45188.1 - 0.077 12.7 0.1 0.47 10.1 0.1 2.0 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 zf-C2H2_4 PF13894.6 EFE45189.1 - 0.32 12.0 0.2 0.32 12.0 0.2 3.4 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFE45189.1 - 1.9 9.1 4.5 34 5.2 0.3 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type IHABP4_N PF16174.5 EFE45189.1 - 2.9 8.5 12.1 1.5 9.4 3.9 2.6 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal CMD PF02627.20 EFE45192.1 - 2.1e-08 34.1 0.2 5.8e-07 29.5 0.0 2.3 2 1 0 2 2 2 2 Carboxymuconolactone decarboxylase family CBFD_NFYB_HMF PF00808.23 EFE45193.1 - 2.4e-21 75.8 1.1 3.1e-21 75.4 1.1 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFE45193.1 - 0.00057 20.2 0.0 0.00087 19.7 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EFE45193.1 - 0.0025 17.8 0.0 0.0038 17.2 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-18kDa PF02269.16 EFE45193.1 - 0.0051 16.8 0.0 0.0076 16.2 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-T_C PF15511.6 EFE45193.1 - 0.096 12.8 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 EFE45193.1 - 0.12 12.9 0.0 0.2 12.2 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A DUF2828 PF11443.8 EFE45195.1 - 0.47 8.5 3.5 0.51 8.4 3.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Presenilin PF01080.17 EFE45195.1 - 0.94 8.2 3.0 1 8.1 3.0 1.1 1 0 0 1 1 1 0 Presenilin Prefoldin_2 PF01920.20 EFE45196.1 - 1.9e-16 59.9 0.2 2.6e-16 59.5 0.2 1.2 1 0 0 1 1 1 1 Prefoldin subunit PAP_central PF04928.17 EFE45196.1 - 0.076 12.0 0.8 2.2 7.2 0.0 2.2 1 1 1 2 2 2 0 Poly(A) polymerase central domain FUSC PF04632.12 EFE45196.1 - 0.096 11.2 0.3 0.1 11.1 0.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2956 PF11169.8 EFE45196.1 - 0.43 10.8 4.4 1.1 9.5 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Fungal_trans PF04082.18 EFE45197.1 - 1.3e-20 73.6 0.0 1.3e-20 73.6 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain TFIIA PF03153.13 EFE45197.1 - 0.0035 17.4 25.1 0.0062 16.6 9.1 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit TF_Zn_Ribbon PF08271.12 EFE45197.1 - 0.033 13.7 0.1 0.078 12.5 0.1 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding CCDC53 PF10152.9 EFE45197.1 - 0.97 9.8 15.4 0.11 12.9 1.2 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Neur_chan_memb PF02932.16 EFE45197.1 - 5.5 7.0 12.2 7.8 6.5 8.2 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region MPM1 PF17234.2 EFE45197.1 - 7.7 6.7 10.1 16 5.7 10.1 1.5 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Aminotran_1_2 PF00155.21 EFE45198.1 - 2.2e-19 69.9 0.0 3.1e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EFE45198.1 - 0.017 13.9 0.0 0.078 11.8 0.0 1.8 1 1 0 1 1 1 0 Alanine-glyoxylate amino-transferase Pkinase PF00069.25 EFE45199.1 - 6.5e-54 183.1 0.0 8.7e-54 182.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE45199.1 - 5.1e-40 137.4 0.0 8.2e-40 136.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFE45199.1 - 0.0011 17.8 0.0 0.0022 16.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFE45199.1 - 0.0032 16.8 0.1 0.0089 15.4 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFE45199.1 - 0.0051 16.2 0.0 0.0084 15.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFE45199.1 - 0.014 14.4 1.9 0.02 13.9 0.0 2.0 3 0 0 3 3 3 0 Haspin like kinase domain APH PF01636.23 EFE45199.1 - 0.038 13.9 0.1 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 EFE45201.1 - 9.5e-69 231.7 0.0 1.4e-68 231.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFE45201.1 - 5.8e-35 120.8 0.1 1.3e-34 119.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFE45201.1 - 9.8e-06 25.1 0.0 1.6e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFE45201.1 - 0.003 17.0 0.0 0.0063 15.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TetR_C_27 PF17935.1 EFE45201.1 - 0.058 13.4 0.0 0.51 10.4 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain YrbL-PhoP_reg PF10707.9 EFE45201.1 - 0.076 12.5 1.2 0.28 10.7 0.0 2.5 4 0 0 4 4 4 0 PhoP regulatory network protein YrbL Methyltransf_8 PF05148.15 EFE45202.1 - 6.4e-58 196.2 0.4 3e-54 184.2 0.0 2.8 3 0 0 3 3 3 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EFE45202.1 - 7.1e-07 29.8 0.0 2.9e-06 27.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFE45202.1 - 2.6e-05 24.8 0.0 0.0013 19.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFE45202.1 - 0.026 14.5 0.0 0.026 14.5 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_31 PF13847.6 EFE45202.1 - 0.079 12.8 0.0 5.1 6.9 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase domain Proteasome PF00227.26 EFE45203.1 - 3e-57 193.2 0.1 3.9e-57 192.8 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFE45203.1 - 3.1e-09 36.3 0.8 6.8e-09 35.2 0.1 2.0 2 1 0 2 2 2 1 Proteasome subunit A N-terminal signature GCP_N_terminal PF17681.1 EFE45204.1 - 4.2e-64 217.1 0.0 6.4e-64 216.5 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFE45204.1 - 5e-52 177.3 2.0 1e-51 176.3 2.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal DUF3346 PF11826.8 EFE45204.1 - 0.11 12.3 0.4 0.21 11.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3346) KH_8 PF17903.1 EFE45205.1 - 1.4e-29 102.0 0.0 3.8e-29 100.6 0.0 1.8 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EFE45205.1 - 0.087 12.7 1.3 0.39 10.6 0.0 2.6 3 0 0 3 3 3 0 KH domain DUF4746 PF15928.5 EFE45205.1 - 0.98 8.8 15.6 1.3 8.4 15.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) adh_short PF00106.25 EFE45207.1 - 7.2e-40 136.5 0.0 9.5e-40 136.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFE45207.1 - 4e-23 82.2 0.0 5.2e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFE45207.1 - 2.4e-06 27.6 0.0 3.9e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFE45207.1 - 0.00082 18.6 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EFE45207.1 - 0.0011 18.4 0.0 0.0015 18.0 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFE45207.1 - 0.073 12.5 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 EFE45207.1 - 0.14 12.1 0.1 0.23 11.3 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GalP_UDP_tr_C PF02744.17 EFE45208.1 - 2.5e-40 137.9 3.2 5.4e-38 130.3 2.7 2.6 1 1 1 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain GalP_UDP_transf PF01087.22 EFE45208.1 - 1.9e-35 122.9 0.0 2.6e-34 119.2 0.0 2.5 2 1 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Trichophyton_verrucosum_HKI_0517-ASM15150v1/GCA_000151505.1_ASM15150v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Trichophyton_verrucosum_HKI_0517-ASM15150v1/GCA_000151505.1_ASM15150v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Trichophyton_verrucosum_HKI_0517-ASM15150v1/GCA_000151505.1_ASM15150v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Trichophyton_verrucosum_HKI_0517-ASM15150v1/GCA_000151505.1_ASM15150v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 07:35:44 2019 # [ok]